format-version: 1.2 data-version: releases/2025-12-17 subsetdef: abnormal_slim "" subsetdef: added_for_HCA "" subsetdef: attribute_slim "" subsetdef: BDS_subset "" subsetdef: blood_and_immune_upper_slim "a subset of general classes related to blood and the immune system, primarily of hematopoietic origin" subsetdef: cell_quality "" subsetdef: common_anatomy "" subsetdef: cumbo "" subsetdef: cyclostome_subset "" subsetdef: developmental_classification "" subsetdef: disposition_slim "" subsetdef: dubious_grouping "" subsetdef: early_development "" subsetdef: efo_slim "" subsetdef: emapa_ehdaa2 "" subsetdef: eye_upper_slim "a subset of general classes related to specific cell types in the eye." subsetdef: functional_classification "" subsetdef: general_cell_types_upper_slim "a subset of general classes of cell types in the cell ontology." subsetdef: gocheck_do_not_annotate "" subsetdef: gocheck_obsoletion_candidate "" subsetdef: goslim_agr "" subsetdef: goslim_candida "" subsetdef: goslim_chembl "" subsetdef: goslim_drosophila "" subsetdef: goslim_euk_cellular_processes_ribbon "" subsetdef: goslim_flybase_ribbon "" subsetdef: goslim_generic "" subsetdef: goslim_metagenomics "" subsetdef: goslim_mouse "" subsetdef: goslim_pir "" subsetdef: goslim_plant "" subsetdef: goslim_plant_ribbon "" subsetdef: goslim_pombe "" subsetdef: goslim_prokaryote "" subsetdef: goslim_prokaryote_ribbon "" subsetdef: goslim_synapse "" subsetdef: goslim_yeast "" subsetdef: grouping_class "" subsetdef: homology_grouping "" subsetdef: hpo_slim "" subsetdef: http://purl.obolibrary.org/obo/valid_for_go_annotation_extension "" subsetdef: http://purl.obolibrary.org/obo/valid_for_go_gp2term "" subsetdef: http://purl.obolibrary.org/obo/valid_for_go_ontology "" subsetdef: http://purl.obolibrary.org/obo/valid_for_gocam "" subsetdef: human_reference_atlas "" subsetdef: human_subset "" subsetdef: inconsistent_with_fma "" subsetdef: kidney_upper_slim "a subset of general classes related to specific cell types in the kidney" subsetdef: location_grouping "" subsetdef: major_organ "" subsetdef: mouse_subset "" subsetdef: mpath_slim "" subsetdef: non_informative "" subsetdef: organ_slim "" subsetdef: pheno_slim "" subsetdef: phenotype_rcn "" subsetdef: ro-eco "" subsetdef: RO:0002259 "" subsetdef: scalar_slim "" subsetdef: uberon_slim "" subsetdef: ubprop:upper_level "abstract upper-level terms not directly useful for analysis" subsetdef: unverified_taxonomic_grouping "" subsetdef: upper_level "" subsetdef: value_slim "" subsetdef: vertebrate_core "" synonymtypedef: blast_name "" synonymtypedef: COMPARATIVE_PREFERRED "" synonymtypedef: DEPRECATED "" synonymtypedef: DEVELOPMENTAL "" synonymtypedef: equivalent_name "" synonymtypedef: genbank_common_name "" synonymtypedef: Gene-based "" synonymtypedef: HOMOLOGY "" synonymtypedef: HUMAN_PREFERRED "" synonymtypedef: HUMAN_PREFERRED "preferred term when talking about an instance of this class in Homo sapiens" synonymtypedef: in_part "" synonymtypedef: INCONSISTENT "" synonymtypedef: LATIN "latin term" synonymtypedef: MISSPELLING "a mis-spelling that is in common use and thus recorded" synonymtypedef: NON_MAMMAL "" synonymtypedef: OMO:0003000 "abbreviation" synonymtypedef: OMO:0003002 "" synonymtypedef: OMO:0003003 "" synonymtypedef: OMO:0003004 "plural form" synonymtypedef: OMO:0003011 "" synonymtypedef: PENDING_REVIEW "" synonymtypedef: PLURAL "plural term" synonymtypedef: PRO-short-label "" synonymtypedef: scientific_name "" synonymtypedef: SENSU "" synonymtypedef: syngo_official_label "" synonymtypedef: synonym "" synonymtypedef: SYSTEMATIC "" synonymtypedef: systematic_synonym "" idspace: CCN20230722 https://purl.brain-bican.org/taxonomy/CCN20230722# idspace: dc http://purl.org/dc/elements/1.1/ idspace: foaf http://xmlns.com/foaf/0.1/ idspace: oboInOwl http://www.geneontology.org/formats/oboInOwl# idspace: skos http://www.w3.org/2004/02/skos/core# idspace: sssom https://w3id.org/sssom/ idspace: terms http://purl.org/dc/terms/ remark: See PMID:15693950, PMID:12799354, PMID:20123131, PMID:21208450; Contact Alexander Diehl, addiehl[at]buffalo.edu, university at buffalo. ontology: cl property_value: dc:description "An ontology of cell types." xsd:string property_value: dc:title "Cell Ontology" xsd:string property_value: IAO:0000700 CL:0000000 property_value: owl:versionInfo "2025-12-17" xsd:string property_value: terms:contributor https://orcid.org/0000-0001-5208-3432 property_value: terms:contributor https://orcid.org/0000-0001-9114-8737 property_value: terms:contributor https://orcid.org/0000-0001-9990-8331 property_value: terms:contributor https://orcid.org/0000-0002-2244-7917 property_value: terms:contributor https://orcid.org/0000-0002-6601-2165 property_value: terms:contributor https://orcid.org/0000-0002-7073-9172 property_value: terms:contributor https://orcid.org/0000-0002-8688-6599 property_value: terms:contributor https://orcid.org/0000-0002-9900-7880 property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 property_value: terms:license http://creativecommons.org/licenses/by/4.0/ [Term] id: BFO:0000002 disjoint_from: BFO:0000003 relationship: BFO:0000050 BFO:0000002 {all_only="true"} ! part of [Term] id: BFO:0000003 relationship: BFO:0000050 BFO:0000003 {all_only="true"} ! part of [Term] id: BFO:0000004 disjoint_from: BFO:0000020 disjoint_from: BFO:0000031 relationship: BFO:0000050 BFO:0000004 {all_only="true"} ! part of [Term] id: BFO:0000019 relationship: BFO:0000050 BFO:0000019 {all_only="true"} ! part of [Term] id: BFO:0000020 disjoint_from: BFO:0000031 relationship: BFO:0000050 BFO:0000020 {all_only="true"} ! part of [Term] id: BFO:0000031 relationship: BFO:0000050 BFO:0000031 {all_only="true"} ! part of [Term] id: BFO:0000040 disjoint_from: BFO:0000141 [Term] id: CHEBI:24431 is_a: BFO:0000040 [Term] id: CHEBI:36080 is_a: BFO:0000002 is_a: PR:000018263 ! amino acid chain equivalent_to: PR:000000001 ! protein [Term] id: CHEBI:46858 is_a: PR:000049928 ! amino-acid residue related to L-tyrosine [Term] id: CL:0000000 name: cell def: "A material entity of anatomical origin (part of or deriving from an organism) that has as its parts a maximally connected cell compartment surrounded by a plasma membrane." [CARO:mah] comment: The definition of cell is intended to represent all cells, and thus a cell is defined as a material entity and not an anatomical structure, which implies that it is part of an organism (or the entirety of one). subset: cellxgene_subset subset: human_subset subset: mouse_subset subset: ubprop:upper_level xref: CALOHA:TS-2035 xref: FBbt:00007002 {sssom:mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"} xref: FMA:68646 xref: GO:0005623 xref: KUPO:0000002 xref: MESH:D002477 xref: VHOG:0001533 xref: WBbt:0004017 xref: XAO:0003012 xref: ZFA:0009000 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: UBERON:0000061 ! anatomical structure disjoint_from: GO:0031012 ! extracellular matrix disjoint_from: GO:0032991 ! protein-containing complex disjoint_from: GO:0043226 ! organelle disjoint_from: GO:0044423 ! virion component relationship: RO:0002162 NCBITaxon:131567 ! in taxon cellular organisms property_value: skos:prefLabel "cell" xsd:string [Term] id: CL:0000001 name: primary cultured cell def: "A cultured cell that is freshly isolated from a organismal source, or derives in culture from such a cell prior to the culture being passaged." [ReO:mhb] comment: Covers cells actively being cultured or stored in a quiescent state for future use. subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "primary cell culture cell" EXACT [] synonym: "primary cell line cell" RELATED [] synonym: "unpassaged cultured cell" EXACT [] xref: BTO:0002290 is_a: CL:0000010 ! cultured cell property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0000001" xsd:string {name="primary cultured cell on CELLxGENE CellGuide"} property_value: terms:description "Primary cultured cells are cells directly extracted from living organisms and then cultivated in a laboratory under controlled environmental conditions. After extraction, these cells can grow and reproduce when provided with the appropriate nutrients. The establishment of primary cell cultures involves processes like tissue dissection, enzymatic or mechanical disaggregation, suspension, and plating. These cells closely mimic the biochemical and physiological conditions of cells in vivo, providing a more realistic model of biological function compared to other cell culture systems.\nRetaining most physiological and morphological characteristics of the original tissue, primary cultured cells are a powerful tool for modeling diseases, drug responses, and basic biological functions such as synthesis and metabolism. They find extensive use in research fields such as cellular biology, genetics, pharmacology, oncology, and toxicology.\nDespite their genetic stability, primary cultured cells have a finite lifespan and are not immortal. They undergo senescence after a specific number of population doublings, influenced by genetic, environmental, and epigenetic factors. Given their limited lifespan, primary cells are crucial for experimental replicability, and their cultivation demands meticulous care to prevent changes that might alter cell identity or function.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1007/978-0-387-89626-7_18", xref="https://www.sciencedirect.com/topics/biochemistry-genetics-and-molecular-biology/primary-cell-culture"} [Term] id: CL:0000002 name: obsolete immortal cell line cell def: "OBSOLETE: A cell line cell that is expected to be capable of an unlimited number of divisions, and is thus able to support indefinite growth/propagation in vitro as part of a immortal cell line." [ReO:mhb] comment: Obsoleted in July 2013 and replaced by the CLO 'immortal cell line cell' class, as a result of CLO-OBI-CL alignment efforts.\n\nCovers cells actively being cultured or stored in a quiescent state for future use. synonym: "continuous cell line cell" EXACT [] synonym: "permanent cell line cell" EXACT [] is_obsolete: true replaced_by: CLO:0000019 [Term] id: CL:0000003 name: obsolete native cell def: "OBSOLETE. A cell that is found in a natural setting, which includes multicellular organism cells 'in vivo' (i.e. part of an organism), and unicellular organisms 'in environment' (i.e. part of a natural environment)." [CARO:mah] subset: ubprop:upper_level synonym: "cell in vivo" NARROW [] xref: CARO:0000013 property_value: IAO:0000233 https://github.com/obophenotype/cell-ontology/issues/2124 is_obsolete: true replaced_by: CL:0000000 [Term] id: CL:0000004 name: obsolete cell by organism def: "OBSOLETE: A classification of cells by the organisms within which they are contained." [FB:ma] comment: This term was made obsolete because there is no difference in meaning between it and 'cell', as any cell can be classified by its species. If you have used this term in annotation, please replace it with cell (CL:0000000), native cell (CL:0000003), or cell in vitro (CL:0001034) as appropriate. is_obsolete: true consider: CL:0000000 consider: CL:0000003 consider: CL:0001034 [Term] id: CL:0000005 name: neural crest derived fibroblast def: "Any fibroblast that is derived from the neural crest." [https://orcid.org/0000-0001-5208-3432] subset: human_subset subset: mouse_subset synonym: "fibroblast neural crest derived" EXACT [] is_a: CL:0000057 ! fibroblast intersection_of: CL:0000057 ! fibroblast intersection_of: RO:0002202 CL:0000333 ! develops from migratory neural crest cell relationship: RO:0002202 CL:0000008 ! develops from migratory cranial neural crest cell [Term] id: CL:0000006 name: neuronal receptor cell def: "Any sensory receptor cell that is a(n) neuron and is capable of some detection of stimulus involved in sensory perception." [FBC:Autogenerated] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "neuronal receptor cell (sensu Animalia)" EXACT [] xref: ZFA:0009001 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000101 ! sensory neuron is_a: CL:0000197 ! sensory receptor cell intersection_of: CL:0000197 ! sensory receptor cell intersection_of: CL:0000540 ! neuron intersection_of: RO:0002215 GO:0050906 ! capable of detection of stimulus involved in sensory perception property_value: skos:prefLabel "neuronal receptor cell" xsd:string [Term] id: CL:0000007 name: early embryonic cell (metazoa) def: "A cell found in the embryo before the formation of all the gem layers is complete." [GOC:tfm] subset: human_subset subset: mouse_subset xref: ZFA:0009002 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0002321 ! embryonic cell (metazoa) property_value: skos:prefLabel "early embryonic cell (metazoa)" xsd:string [Term] id: CL:0000008 name: migratory cranial neural crest cell def: "Cell that is part of the migratory cranial neural crest population. Migratory cranial neural crest cells develop from premigratory cranial neural crest cells and have undergone epithelial to mesenchymal transition and delamination." [https://orcid.org/0000-0001-5208-3432, ZFA:0007091] subset: human_subset subset: mouse_subset xref: ZFA:0007091 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000333 ! migratory neural crest cell property_value: skos:prefLabel "migratory cranial neural crest cell" xsd:string [Term] id: CL:0000009 name: obsolete fusiform initial alt_id: CL:0000274 def: "Obsolete. Use PO:0000079 from Plant Ontology instead. An elongated cell with approximately wedge-shaped ends, found in the vascular cambium, which gives rise to the elements of the axial system in the secondary vascular tissues." [ISBN:0471245208] synonym: "xylem initial" RELATED [] synonym: "xylem mother cell" RELATED [] is_obsolete: true replaced_by: PO:0000079 [Term] id: CL:0000010 name: cultured cell def: "A cell in vitro that is or has been maintained or propagated as part of a cell culture." [ReO:mhb] comment: Note that this class was re-labeled to 'cultured cell' instead of 'cell line cell', as it intent was clarified to cover any cultured cells of multicellular and unicellular organisms. This includes cells actively being cultured, or cells that have been cultured but are stored in a quiescent state for future use. In having been cultured, cells must establish homeostasis and often replicate in a foreign environment. Accomodation of this stress initiates a selection of cells fit for such challenges, wherein necessary adaptive biochemical and.or genetic changes can occur. These changes can set them apart from the in vivo cells from which they derive, and such changes will typically accumulate and change over increasing time in culture. subset: human_subset subset: mouse_subset xref: MESH:D002478 is_a: CL:0000578 ! experimentally modified cell in vitro [Term] id: CL:0000011 name: migratory trunk neural crest cell def: "Cell that is part of the migratory trunk neural crest population. Migratory trunk neural crest cells develop from premigratory trunk neural crest cells and have undergone epithelial to mesenchymal transition and delamination." [https://orcid.org/0000-0001-5208-3432, ZFA:0007095] subset: human_subset subset: mouse_subset xref: ZFA:0007095 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000333 ! migratory neural crest cell [Term] id: CL:0000012 name: obsolete cell by class comment: This term was made obsolete because there is no difference in meaning between it and 'cell', as any cell can be classified. If you have used this term in annotation, please replace it with cell (CL:0000000), native cell (CL:0000003), or cell in vitro (CL:0001034) as appropriate. is_obsolete: true consider: CL:0000000 consider: CL:0000003 consider: CL:0001034 [Term] id: CL:0000013 name: obsolete dentine secreting cell is_obsolete: true consider: CL:0000140 [Term] id: CL:0000014 name: germ line stem cell def: "A stem cell that is the precursor of gametes." [doi:10.1016/j.stem.2012.05.016] subset: human_subset subset: mouse_subset synonym: "germline stem cell" EXACT [] xref: FBbt:00004861 {sssom:mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"} xref: ZFA:0005956 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000034 {is_inferred="true"} ! stem cell is_a: CL:0000039 ! germ line cell intersection_of: CL:0000039 ! germ line cell intersection_of: RO:0002215 GO:0017145 ! capable of stem cell division [Term] id: CL:0000015 name: male germ cell def: "A germ cell that supports male gamete production. In some species, non-germ cells known as Sertoli cells also play a role in spermatogenesis." [https://orcid.org/0000-0001-5208-3432, PMID:29462262] subset: cellxgene_subset subset: human_subset subset: mouse_subset xref: FMA:72290 xref: MA:0002765 xref: ncithesaurus:Spermatogenic_Cell xref: VHOG:0001531 is_a: CL:0000586 {is_inferred="true"} ! germ cell relationship: RO:0002216 GO:0007283 ! capable of part of spermatogenesis property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0000015" xsd:string {name="male germ cell on CELLxGENE CellGuide"} property_value: seeAlso "https://github.com/obophenotype/cell-ontology/issues/574" xsd:string property_value: terms:description "Male germ cells are specialized cells that give rise to the male gametes and are therefore crucial for sexual reproduction in males. Through a complex process called spermatogenesis in the testes male germ cells undergo several stages of development, each with distinctive morphological and physiological characteristics, eventually differentiating into mature spermatozoa (sperm). \nMale germ cells are responsible for transferring genetic material from male to offspring as part of sexual reproduction. In the initial stage of their life cycle, they exist as spermatogonial stem cells, which multiply by mitotic division to self-renew and to produce daughter cells. The daughter cells then undergo meiotic division, a process that reduces the number of chromosomes in each cell by half, from diploid to haploid – the formation of spermatids. This is critical for maintaining genetic stability from generation to generation, as it ensures that when an egg and sperm cell unite during fertilization, the resulting offspring will have the correct number of chromosomes. The final phase of spermatogenesis is called spermiogenesis, during which spermatozoa - mature and motile sperm cells – are produced from round spermatids. \nThe matured male germ cells or sperm cells are highly specialized, having a streamlined shape designed for efficient movement towards the female egg. A sperm cell is divided into three main parts, namely the head, midpiece, and tail. The head contains the genetic material, the midpiece contains mitochondria that provide energy, and the tail, termed as the flagellum, propels the sperm cell forward. Each of these parts play significant roles in fertilization.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1016/S0092-8674(00)81834-6", xref="DOI:10.1016/S1534-5807(02)00173-9", xref="DOI:10.1242/dev.202046", xref="https://www.ncbi.nlm.nih.gov/books/NBK553142/"} [Term] id: CL:0000016 name: male germ line stem cell def: "A stem cell that is the precursor of male gametes." [doi:10.1016/j.stem.2012.05.016] subset: human_subset subset: mouse_subset xref: FBbt:00004929 {sssom:mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"} is_a: CL:0000014 ! germ line stem cell is_a: CL:0000015 ! male germ cell [Term] id: CL:0000017 name: spermatocyte def: "A male germ cell that develops from spermatogonia. The euploid primary spermatocytes undergo meiosis and give rise to the haploid secondary spermatocytes which in turn give rise to spermatids." [GOC:tfm, MESH:D013090] subset: cellxgene_subset subset: human_subset subset: mouse_subset xref: BTO:0001275 xref: CALOHA:TS-0951 xref: EMAPA:31484 xref: FBbt:00004936 {sssom:mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"} xref: FMA:84049 xref: WBbt:0006799 xref: ZFA:0009005 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: BFO:0000002 is_a: CL:0000015 ! male germ cell intersection_of: CL:0000015 ! male germ cell intersection_of: RO:0002215 GO:0048137 ! capable of spermatocyte division relationship: RO:0002202 CL:0000020 ! develops from spermatogonium relationship: RO:0002215 GO:0048137 ! capable of spermatocyte division [Term] id: CL:0000018 name: spermatid def: "A male germ cell that develops from the haploid secondary spermatocytes. Without further division, spermatids undergo structural changes and give rise to spermatozoa." [MESH:D013087] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "nematoblast" EXACT [] xref: BTO:0001274 xref: CALOHA:TS-0950 xref: EMAPA:31486 xref: FBbt:00004942 {sssom:mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"} xref: FMA:72294 xref: WBbt:0006800 xref: ZFA:0005769 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: BFO:0000002 is_a: CL:0000015 ! male germ cell is_a: CL:0000255 ! eukaryotic cell is_a: CL:0000413 ! haploid cell intersection_of: CL:0000015 ! male germ cell intersection_of: RO:0000053 PATO:0001375 ! has characteristic haploid intersection_of: RO:0002215 GO:0001675 ! capable of acrosome assembly intersection_of: RO:0002215 GO:0007288 ! capable of sperm axoneme assembly intersection_of: RO:0002215 GO:0007289 ! capable of spermatid nucleus differentiation relationship: RO:0002202 CL:0000657 ! develops from secondary spermatocyte relationship: RO:0002215 GO:0001675 ! capable of acrosome assembly relationship: RO:0002215 GO:0007288 ! capable of sperm axoneme assembly relationship: RO:0002215 GO:0007289 ! capable of spermatid nucleus differentiation [Term] id: CL:0000019 name: sperm def: "A mature male germ cell that develops from a spermatid." [GOC:tfm, MESH:D013094] subset: human_subset subset: mouse_subset synonym: "sperm cell" EXACT [] synonym: "spermatozoid" EXACT [] synonym: "spermatozoon" EXACT [] xref: BTO:0001277 xref: BTO:0002046 xref: CALOHA:TS-0949 xref: FBbt:00004954 {sssom:mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"} xref: FMA:67338 xref: WBbt:0006798 xref: ZFA:0009006 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: BFO:0000002 is_a: CL:0000255 ! eukaryotic cell is_a: CL:0000408 {is_inferred="true"} ! male gamete relationship: RO:0002202 CL:0000018 ! develops from spermatid property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0000019" xsd:string {name="sperm on CELLxGENE CellGuide"} property_value: terms:description "Sperm cells, also known as spermatozoa or male gametes, are highly specialized cells that are pivotal for sexual reproduction in animals. Produced in the male reproductive organs, specifically the testes, sperm cells play an important role in the process of fertilization, where they fuse with a female gamete or egg cell (ovum) to form a zygote, which marks the beginning of a new organism.\nSperm cells hold several unique traits that set them apart from other body cells. Structurally, a sperm cell possesses two main structures: the head, containing the nucleus carrying the paternal genetic information, and the flagellum, which generates energy and grants the sperm cell mobility\nThe process of fertilization occurs when one sperm cell successfully penetrates the egg, delivering its genetic information, and ultimately leading to the formation of a new individual combining both paternal and maternal genetic materials. Notably, while hundreds of millions of sperm cells may be released during ejaculation, only one has the opportunity to successfully fertilize the egg, underscoring the highly competitive nature of this biological process.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1080/19420889.2015.1017156", xref="DOI:10.1152/physrev.00009.2020", xref="https://www.ncbi.nlm.nih.gov/books/NBK26914/"} [Term] id: CL:0000020 name: spermatogonium def: "An euploid male germ cell of an early stage of spermatogenesis." [MESH:D013093] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "spermatogonial cell" EXACT [] xref: BTO:0000958 xref: CALOHA:TS-2193 xref: EMAPA:31482 xref: FBbt:00004934 {sssom:mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"} xref: FBbt:00004935 {sssom:mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"} xref: FMA:72291 xref: ZFA:0009007 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000015 ! male germ cell intersection_of: CL:0000015 ! male germ cell intersection_of: RO:0000053 PATO:0001394 ! has characteristic diploid intersection_of: RO:0000053 PATO:0001501 ! has characteristic immature relationship: RO:0000053 PATO:0001394 ! has characteristic diploid relationship: RO:0000053 PATO:0001501 ! has characteristic immature [Term] id: CL:0000021 name: female germ cell def: "Female germ cell is a germ cell that supports female gamete production." [GOC:tfm, PMID:11023867, PMID:20454446] subset: cellxgene_subset subset: human_subset subset: mouse_subset xref: MA:0000388 xref: ncithesaurus:Egg xref: VHOG:0001530 is_a: CL:0000255 ! eukaryotic cell is_a: CL:0000586 {is_inferred="true"} ! germ cell intersection_of: CL:0000586 ! germ cell intersection_of: RO:0002215 GO:0048477 ! capable of oogenesis relationship: RO:0002215 GO:0048477 ! capable of oogenesis [Term] id: CL:0000022 name: female germ line stem cell def: "A stem cell that is the precursor of female gametes." [doi:10.1016/j.stem.2012.05.016] subset: human_subset subset: mouse_subset xref: FBbt:00004873 {sssom:mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"} is_a: CL:0000014 {is_inferred="true"} ! germ line stem cell is_a: CL:0000021 {is_inferred="true"} ! female germ cell intersection_of: CL:0000021 ! female germ cell intersection_of: RO:0002215 GO:0017145 ! capable of stem cell division [Term] id: CL:0000023 name: oocyte def: "A female germ cell that has entered meiosis." [GOC:tfm, ISBN:0721662544] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "oogonium" RELATED [] xref: BTO:0000964 xref: CALOHA:TS-0711 xref: FBbt:00004886 {sssom:mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"} xref: FMA:18644 xref: MESH:D009865 xref: WBbt:0006797 xref: ZFA:0001109 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: BFO:0000002 is_a: CL:0000021 {is_inferred="true"} ! female germ cell relationship: RO:0000056 GO:0007143 ! participates in female meiotic nuclear division [Term] id: CL:0000024 name: oogonial cell def: "An undifferentiated germ cell that proliferates rapidly and gives rise to oocytes." [GOC:tfm, ISBN:0721662544] subset: cellxgene_subset subset: human_subset subset: mouse_subset xref: FMA:83673 xref: ZFA:0005878 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: BFO:0000002 is_a: CL:0000021 {is_inferred="true"} ! female germ cell intersection_of: CL:0000021 ! female germ cell intersection_of: RO:0002215 GO:0000278 ! capable of mitotic cell cycle relationship: RO:0002202 CL:0000670 ! develops from primordial germ cell relationship: RO:0002215 GO:0000278 ! capable of mitotic cell cycle [Term] id: CL:0000025 name: egg cell def: "A female gamete where meiosis has progressed to metaphase II and is able to participate in fertilization." [GOC:tfm, ISBN:0721662544] subset: human_subset subset: mouse_subset synonym: "mature oocyte" EXACT [] synonym: "ovum" EXACT [] xref: BTO:0000369 xref: BTO:0003801 xref: CALOHA:TS-2191 xref: FBbt:00057012 {sssom:mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"} xref: FMA:67343 xref: MESH:D010063 xref: ZFA:0001570 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: BFO:0000002 is_a: CL:0000675 {is_inferred="true"} ! female gamete relationship: RO:0000056 GO:0007143 ! participates in female meiotic nuclear division relationship: RO:0002202 CL:0000023 ! develops from oocyte property_value: foaf:depiction "https://www.swissbiopics.org/api/image/Egg_cell.svg" xsd:anyURI [Term] id: CL:0000026 name: invertebrate nurse cell def: "A germline cell that contributes to the development of the oocyte by transferring cytoplasm directly to oocyte." [GOC:tfm, PMID:15848391] synonym: "nurse cell" RELATED [] xref: BTO:0000953 xref: FBbt:00004878 {sssom:mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"} is_a: BFO:0000002 is_a: CL:0000255 ! eukaryotic cell is_a: CL:0000412 ! polyploid cell is_a: CL:4029002 ! germline-derived nurse cell relationship: RO:0002202 CL:0000722 ! develops from cystoblast [Term] id: CL:0000027 name: smooth muscle cell neural crest derived def: "A smooth muscle cell derived from the neural crest." [https://orcid.org/0000-0001-5208-3432] subset: human_subset subset: mouse_subset is_a: CL:0000192 {is_inferred="true"} ! smooth muscle cell intersection_of: CL:0000192 ! smooth muscle cell intersection_of: RO:0002202 CL:0000333 ! develops from migratory neural crest cell relationship: RO:0002202 CL:0000008 ! develops from migratory cranial neural crest cell [Term] id: CL:0000028 name: CNS neuron (sensu Nematoda and Protostomia) is_a: BFO:0000002 is_a: CL:2000029 ! central nervous system neuron relationship: BFO:0000050 UBERON:0001017 ! part of central nervous system relationship: RO:0002202 CL:0000338 ! develops from neuroblast (sensu Nematoda and Protostomia) [Term] id: CL:0000029 name: neural crest derived neuron def: "Any neuron that develops from some migratory neural crest cell." [FBC:Autogenerated] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "neuron neural crest derived" EXACT [] xref: ZFA:0009009 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: BFO:0000002 is_a: CL:0000540 {is_inferred="true"} ! neuron intersection_of: CL:0000540 ! neuron intersection_of: RO:0002202 CL:0000333 ! develops from migratory neural crest cell relationship: RO:0002202 CL:0002676 ! develops from neural crest derived neuroblast property_value: skos:prefLabel "neural crest derived neuron" xsd:string [Term] id: CL:0000030 name: glioblast def: "A non-terminally differentiated cell that develops form the neuroectoderm. Glioblast has the potential to differentiate into various types of glial cells, including astrocytes and oligodendrocytes." [PMID:37824650, Wikipedia:Glioblast] subset: cellxgene_subset subset: human_subset subset: mouse_subset xref: ZFA:0009010 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0011026 ! progenitor cell relationship: RO:0002202 CL:0000133 ! develops from neurectodermal cell property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0000030" xsd:string {name="glioblast on CELLxGENE CellGuide"} property_value: terms:description "Glioblasts are primarily found in the central nervous system and are an integral part of the developing and mature brain tissue. They are primitive progenitor cells with the ability to self-renew and can differentiate into neuroglia, including astrocytes and oligodendrocytes, two primary cells involved in neurotransmission and protection of brain tissue. \nWhen glioblast multiplication is dysregulated, it can lead to harmful manifestations, most notably in the form of an aggressive brain tumor known as Glioblastoma multiforme, one of the most malignant types of neural cancers.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1073/pnas.97.12.6242", xref="DOI:10.1186/s13064-016-0075-9", xref="DOI:10.12688/f1000research.22405.1", xref="DOI:10.4252/wjsc.v6.i2.230"} [Term] id: CL:0000031 name: neuroblast (sensu Vertebrata) alt_id: CL:0000337 def: "A cell that will develop into a neuron often after a migration phase." [GOC:NV, http://en.wikipedia.org/wiki/Neuroblast] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "neuroblast" EXACT [] xref: BTO:0000930 xref: FMA:70563 xref: ZFA:0009011 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0011026 ! progenitor cell relationship: RO:0002162 NCBITaxon:7742 ! in taxon Vertebrata property_value: skos:prefLabel "neuroblast (sensu Vertebrata)" xsd:string [Term] id: CL:0000032 name: neuroplacodal cell def: "A cell of a platelike structure, especially a thickened plate of ectoderm in the early embryo, from which a sense organ develops." [GOC:tfm, ISBN:0618947256] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "neural placode cell" EXACT [] xref: ZFA:0009012 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: BFO:0000002 is_a: CL:0000255 ! eukaryotic cell is_a: CL:0002321 ! embryonic cell (metazoa) relationship: RO:0002202 CL:0000114 ! develops from surface ectodermal cell [Term] id: CL:0000033 name: apocrine cell def: "An exocrine cell characterized by loss of part of the cytoplasm during the process of secretion. The secreted substance is accumulated at the apical end and is either budded off through the plasma membrane producing secreted vesicles or dissolved in the cytoplasm that is lost during secretion." [GOC:tfm, ISBN:0721662544, PMID:25960390] subset: human_reference_atlas subset: human_subset subset: mouse_subset is_a: CL:0000152 ! exocrine cell property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0000034 name: stem cell def: "A relatively undifferentiated cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells." [GOC:tfm, MESH:D013234] comment: This term applies to metazoan. For plant stem cells, consider using PO:0004011 ‘initial cell’ or its parent PO:0004010 ‘meristematic cell’. subset: cellxgene_subset subset: general_cell_types_upper_slim subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "animal stem cell" EXACT [] xref: CALOHA:TS-2086 xref: FMA:63368 xref: ZFA:0005957 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000255 ! eukaryotic cell is_a: CL:0011115 ! precursor cell intersection_of: CL:0000000 ! cell intersection_of: RO:0002215 GO:0017145 ! capable of stem cell division relationship: RO:0002162 NCBITaxon:33208 ! in taxon Metazoa relationship: RO:0002215 GO:0017145 ! capable of stem cell division property_value: RO:0002175 NCBITaxon:9606 property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0000034" xsd:string {name="stem cell on CELLxGENE CellGuide"} property_value: skos:prefLabel "stem cell" xsd:string property_value: terms:description "Stem cells are a unique type of cell that has the remarkable ability to divide and develop into many different types of cells in the body. These cells are undifferentiated, meaning they haven't yet developed into a specific cell type, and they can renew themselves through cell division. As a result, stem cells have the potential to replace damaged or diseased cells in the body, making them a valuable tool in medicine and research.\nThere are two main types of stem cells: embryonic stem cells and adult stem cells. Embryonic stem cells are derived from embryos and can develop into any type of cell in the body. Adult stem cells, on the other hand, are found in various tissues and organs throughout the body and can only develop into certain types of cells.\nStem cells have numerous potential applications in medicine, including the treatment of various diseases and the repair of damaged tissues. For example, they could be used to replace damaged heart tissue after a heart attack or to repair spinal cord injuries. Stem cells also have potential uses in drug development and disease research, as they can be used to model diseases and test potential therapies in vitro.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1016/j.cell.2016.05.043", xref="DOI:10.1016/j.cell.2018.09.010", xref="DOI:10.1016/j.stem.2023.05.015", xref="DOI:10.1038/nm.4502", xref="https://www.mayoclinic.org/tests-procedures/bone-marrow-transplant/in-depth/stem-cells/art-20048117#:~:text=These%20stem%20cells%20are%20manipulated,injected%20into%20the%20heart%20muscle."} [Term] id: CL:0000035 name: single fate stem cell def: "A stem cell that self-renews as well as give rise to a single mature cell type." [GOC:tfm] subset: human_subset subset: mouse_subset synonym: "unipotent stem cell" EXACT [] synonym: "unipotential stem cell" EXACT [] xref: FMA:70569 xref: ZFA:0009013 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000723 ! somatic stem cell intersection_of: CL:0000000 ! cell intersection_of: RO:0000053 PATO:0001400 ! has characteristic unipotent intersection_of: RO:0002215 GO:0017145 ! capable of stem cell division relationship: RO:0000053 PATO:0001400 ! has characteristic unipotent property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0000035" xsd:string {name="single fate stem cell on CELLxGENE CellGuide"} property_value: terms:description "Single fate stem cells, or unipotent stem cells, constitute a distinctive subtype among the diverse range of stem cells, exhibiting significant biological roles and applications. These cells possess the inherent ability to self-renew and generate a single, specialized cell lineage exclusive to their nature, reflecting their unipotent or single fate characteristic. Engaged in the maintenance and regeneration of specific tissues or organs, these stem cells play a crucial role as pivotal contributors to the body's self-maintenance and repair mechanisms.\nSingle fate stem cells play a crucial role in the body's diverse tissues by ensuring the appropriate renewal and repair mechanisms specific to their respective tissues. For example, the human skin, where basal cells located at the base layer of the epidermis act as single fate stem cells. These basal cells continuously generate new keratinocytes, replacing the older ones shed from the skin surface. This perpetual cycle of renewal exemplifies the fundamental function of single fate stem cells—specialized cellular regeneration to uphold tissue homeostasis and function.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1016/j.cps.2017.02.020", xref="DOI:10.52965/001c.37498", xref="https://training.seer.cancer.gov/melanoma/anatomy/layers.html", xref="https://www.sciencedirect.com/topics/immunology-and-microbiology/stem-cell"} [Term] id: CL:0000036 name: epithelial fate stem cell def: "A somatic stem cell that is committed to an epithelial fate, possessing the capacity for self-renewal and the ability to differentiate into one or more distinct mature cell types of the epithelial lineage. This cell is crucial for the development, homeostasis, repair, and regeneration of epithelial tissues." [doi:/10.1038/sj.eye.6700575, PMID:17289566] subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "epithelial stem cell" EXACT [] is_a: CL:0000723 ! somatic stem cell intersection_of: CL:0000723 ! somatic stem cell intersection_of: RO:0002215 GO:0030855 ! capable of epithelial cell differentiation relationship: RO:0002215 GO:0030855 ! capable of epithelial cell differentiation property_value: RO:0002175 NCBITaxon:9606 property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0000036" xsd:string {name="epithelial fate stem cell on CELLxGENE CellGuide"} property_value: terms:description "Epithelial fate stem cells, also known as epithelial stem cells, possess remarkable abilities for self-renewal and the generation of diverse cell types constituting epithelial tissues. The epithelium, derived from these cells, acts as the body's frontline defense against external threats and facilitates the exchange of nutrients, gases, and waste materials within the internal environment.\nEpithelial fate stem cells contribute to tissue development, homeostasis, and repair, maintaining the structural and functional stability of epithelial tissues throughout the human body, including the skin, organs, and glands. Through a delicate balance of quiescence, proliferation, and differentiation, these cells ensure the continuous turnover of epithelial cells.\nFurthermore, these cells serve a critical role in cellular differentiation, where initially unspecialized stem cells mature into specialized entities that perpetuate the functionality of epithelial tissues. This process is intricately regulated by a network of gene expression patterns and external signaling cues to guarantee a coordinated and balanced cellular turnover. Hence, epithelial fate stem cells, with their unique attributes of self-renewal and differentiation, are central to the physiological and reparative functions performed by epithelial tissues in the human body.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1016/j.cell.2007.01.014", xref="DOI:10.1016/j.celrep.2022.111451", xref="DOI:10.1016/j.stem.2020.09.011", xref="DOI:10.1038/nrm2766"} [Term] id: CL:0000037 name: hematopoietic stem cell def: "A stem cell from which all cells of the lymphoid and myeloid lineages develop, including blood cells and cells of the immune system. Hematopoietic stem cells lack cell markers of effector cells (lin-negative). Lin-negative is defined by lacking one or more of the following cell surface markers: CD2, CD3 epsilon, CD4, CD5 ,CD8 alpha chain, CD11b, CD14, CD19, CD20, CD56, ly6G, ter119." [GOC:add, GOC:dsd, GOC:tfm, http://en.wikipedia.org/wiki/Hematopoietic_stem_cell, PMID:19022770] comment: Markers differ between species, and two sets of markers have been described for mice. HSCs are reportedly CD34-positive, CD45-positive, CD48-negative, CD150-positive, CD133-positive, and CD244-negative. subset: blood_and_immune_upper_slim subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "blood forming stem cell" EXACT [] synonym: "colony forming unit hematopoietic" RELATED [] synonym: "hemopoietic stem cell" EXACT [] synonym: "HSC" RELATED OMO:0003000 [] xref: BTO:0000725 xref: CALOHA:TS-0448 xref: FMA:86475 xref: MESH:D006412 xref: VHOG:0001485 xref: ZFA:0009014 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000723 ! somatic stem cell is_a: CL:0008001 ! hematopoietic precursor cell is_a: CL:0011026 ! progenitor cell intersection_of: CL:0000988 ! hematopoietic cell intersection_of: CL:4030046 PR:000001002 ! lacks_plasma_membrane_part CD19 molecule intersection_of: CL:4030046 PR:000001004 ! lacks_plasma_membrane_part CD4 molecule intersection_of: CL:4030046 PR:000001012 ! lacks_plasma_membrane_part integrin alpha-M intersection_of: CL:4030046 PR:000001020 ! lacks_plasma_membrane_part CD3 epsilon intersection_of: CL:4030046 PR:000001024 ! lacks_plasma_membrane_part neural cell adhesion molecule 1 intersection_of: CL:4030046 PR:000001083 ! lacks_plasma_membrane_part CD2 molecule intersection_of: CL:4030046 PR:000001084 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD8 alpha chain intersection_of: CL:4030046 PR:000001289 ! lacks_plasma_membrane_part membrane-spanning 4-domains subfamily A member 1 intersection_of: CL:4030046 PR:000001839 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD5 intersection_of: CL:4030046 PR:000001889 ! lacks_plasma_membrane_part CD14 molecule intersection_of: CL:4030046 PR:000002978 ! lacks_plasma_membrane_part lymphocyte antigen 6G intersection_of: CL:4030046 PR:000002981 ! lacks_plasma_membrane_part lymphocyte antigen 76 (mouse) intersection_of: RO:0002215 GO:0002244 ! capable of hematopoietic progenitor cell differentiation intersection_of: RO:0002215 GO:0048103 ! capable of somatic stem cell division relationship: CL:4030046 PR:000001002 ! lacks_plasma_membrane_part CD19 molecule relationship: CL:4030046 PR:000001004 ! lacks_plasma_membrane_part CD4 molecule relationship: CL:4030046 PR:000001012 ! lacks_plasma_membrane_part integrin alpha-M relationship: CL:4030046 PR:000001020 ! lacks_plasma_membrane_part CD3 epsilon relationship: CL:4030046 PR:000001024 ! lacks_plasma_membrane_part neural cell adhesion molecule 1 relationship: CL:4030046 PR:000001083 ! lacks_plasma_membrane_part CD2 molecule relationship: CL:4030046 PR:000001084 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD8 alpha chain relationship: CL:4030046 PR:000001289 ! lacks_plasma_membrane_part membrane-spanning 4-domains subfamily A member 1 relationship: CL:4030046 PR:000001839 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD5 relationship: CL:4030046 PR:000001889 ! lacks_plasma_membrane_part CD14 molecule relationship: CL:4030046 PR:000002978 ! lacks_plasma_membrane_part lymphocyte antigen 6G relationship: CL:4030046 PR:000002981 ! lacks_plasma_membrane_part lymphocyte antigen 76 (mouse) relationship: RO:0002202 CL:0000566 ! develops from angioblastic mesenchymal cell relationship: RO:0002215 GO:0002244 ! capable of hematopoietic progenitor cell differentiation property_value: RO:0002175 NCBITaxon:9606 property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0000037" xsd:string {name="hematopoietic stem cell on CELLxGENE CellGuide"} property_value: skos:prefLabel "hematopoietic stem cell" xsd:string property_value: terms:description "Hematopoietic stem cells (HSCs) are multipotent cells, capable of differentiating into a wide variety of specialized blood cells. During embryonic development hematopoietic stem cells emerge from the hemogenic endothelium, a specialized subset of endothelial cells with hematopoietic potential. HSCs can be found in several organs, in particular in bone marrow, as well as peripheral blood and umbilical cord blood.\nThese stem cells have a distinctive ability to self-renew, and to differentiate into all lymphoid and myeloid cell types that together form the blood and immune systems including erythrocytes (red blood cells), leukocytes (white blood cells), and platelets. Their primary function is to ensure the continuous replenishment of the blood and immune system throughout an individual's lifespan.\nIn response to various signals, hematopoietic stem cells can either remain dormant or actively divide and differentiate. Under normal conditions, the majority of these stem cells exist in a quiescent (inactive) state, making them somewhat resistant to chemotherapy or radiation therapy in the treatment of various diseases such as leukemia. However, when the body encounters stress such as infection, bleeding, or disease, hematopoietic stem cells can rapidly become active in order to replenish the affected cells and maintain homeostasis.\nFurthermore, hematopoietic stem cells are extremely important in the field of regenerative medicine and transplantation. Regarded as lifesaving in the field of oncology, they are often extracted, purified, and reinfused back into the same (autologous transplantation) or different (allogeneic transplantation) individuals to reestablish a healthy, functioning hematopoietic and immune system after high-dose chemotherapy or to replace dysfunctional bone marrow. Understanding and manipulating the behavior of these stem cells has immense potential in treating various blood disorders, autoimmune diseases, and cancers.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1038/s41580-019-0103-9", xref="DOI:10.1101/gr.192237.115", xref="DOI:10.1186/s12915-021-00955-z", xref="DOI:10.3389/fcell.2022.664261"} [Term] id: CL:0000038 name: erythroid progenitor cell def: "A progenitor cell committed to the erythroid lineage." [GOC:add, ISBN:0721601464] subset: blood_and_immune_upper_slim subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "BFU-E" RELATED OMO:0003000 [] synonym: "blast forming unit erythroid" RELATED [] synonym: "burst forming unit erythroid" RELATED [] synonym: "CFU-E" RELATED OMO:0003000 [] synonym: "colony forming unit erythroid" RELATED [] synonym: "erythroid stem cell" RELATED [] xref: BTO:0004911 xref: ZFA:0009015 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000764 ! erythroid lineage cell is_a: CL:0000839 {is_inferred="true"} ! myeloid lineage restricted progenitor cell relationship: RO:0002202 CL:0000050 ! develops from megakaryocyte-erythroid progenitor cell property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0000038" xsd:string {name="erythroid progenitor cell on CELLxGENE CellGuide"} property_value: skos:prefLabel "erythroid progenitor cell" xsd:string property_value: terms:description "Erythroid progenitor cells play a key role in the hematopoietic system, specifically in the process of erythropoiesis – the production of red blood cells (erythrocytes). Found within the bone marrow, these cells are dedicated precursors to erythrocytes, and ensue in the hematopoietic lineage from multipotent progenitors. They represent a transitional cell type that bridges the gap between the early-stage erythroid precursors and the maturing red blood cell population.\nThe earliest committed erythroid progenitor cell is thought to be the burst-forming unit-erythroid (BFU-E) cell, which after several cell divisions gives rise to another erythroid progenitor, the colony-forming unit-erythroid (CFU-E) cell. \nErythroid progenitor cells are primarily responsible for responding to the demand for new red blood cells during conditions of physiological stress like infection, blood loss, or illness. This responsive behavior is regulated by a glycoprotein hormone known as erythropoietin, which is produced by the kidneys. Erythropoietin interacts with the receptors on the erythroid progenitor cells, prompting them to proliferate and differentiate into erythroblasts. The erythroblasts then further mature, eventually producing new, functional red cells.\nThe role of erythroid progenitor cells extends beyond their main function of erythrocyte production, as they also participate in maintaining the balance of iron in the body. Upon erythroid differentiation, they increase their uptake of transferrin-bound iron for hemoglobin synthesis, a vital component of red blood cells which allows them to transport oxygen. A deficiency or excess of erythroid progenitor cells can lead to extensive health issues such as anemia or polycythemia respectively, emphasizing their crucial role in human health.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1016/j.exphem.2015.10.007", xref="DOI:10.1097/MOH.0000000000000328", xref="DOI:10.1111/bjh.13938", xref="DOI:10.1182/blood-2014-07-588806", xref="DOI:10.3389/fphys.2019.00304"} [Term] id: CL:0000039 name: germ line cell def: "A cell that is within the developmental lineage of gametes and is able to pass along its genetic material to offspring." [GOC:tfm, ISBN:0721662544] comment: Originally this term had some plant germ line cell children. subset: general_cell_types_upper_slim subset: human_subset subset: mouse_subset subset: ubprop:upper_level xref: ZFA:0009016 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000000 ! cell relationship: RO:0002215 GO:0022414 ! capable of reproductive process property_value: skos:prefLabel "germ line cell" xsd:string [Term] id: CL:0000040 name: monoblast def: "A myeloid progenitor cell committed to the monocyte lineage. This cell is CD11b-positive, has basophilic cytoplasm, euchromatin, and the presence of a nucleolus." [GOC:add, http://en.wikipedia.org/wiki/Monoblast, http://www.copewithcytokines.de, PMID:1104740] comment: Morphology: mononuclear cell, diameter 12-20 _M, non-granular, N/C ratio 3/1 - 4/1; markers: CD11b (shared with many other myeloid cells); location: Adult: bone marrow; fetal: liver, Yolk Sac; role or process: hematopoiesis, monocyte development; lineage: hematopoietic, myeloid. subset: human_subset subset: mouse_subset synonym: "CFU-M" RELATED OMO:0003000 [] synonym: "colony forming unit macrophage" RELATED [] synonym: "colony forming unit monocyte" RELATED [] synonym: "monocyte stem cell" RELATED [] xref: CALOHA:TS-1195 xref: FMA:83553 xref: ZFA:0009017 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000763 ! myeloid cell is_a: CL:0002194 {is_inferred="true"} ! monopoietic cell intersection_of: CL:0002194 ! monopoietic cell intersection_of: BFO:0000051 CL:0017503 ! has part basophilic cytoplasm intersection_of: BFO:0000051 GO:0000791 ! has part euchromatin intersection_of: BFO:0000051 GO:0005730 ! has part nucleolus intersection_of: RO:0002104 PR:000001012 ! has plasma membrane part integrin alpha-M intersection_of: RO:0002215 GO:0030224 ! capable of monocyte differentiation relationship: BFO:0000051 CL:0017503 ! has part basophilic cytoplasm relationship: BFO:0000051 GO:0000791 ! has part euchromatin relationship: BFO:0000051 GO:0005730 ! has part nucleolus relationship: RO:0002104 PR:000001012 ! has plasma membrane part integrin alpha-M relationship: RO:0002202 CL:0002009 ! develops from macrophage dendritic cell progenitor [Term] id: CL:0000041 name: mature eosinophil def: "A fully differentiated eosinophil, a granular leukocyte with a nucleus that usually has two lobes connected by one or more slender threads, and cytoplasm containing coarse, round granules that are uniform in size and which can be stained by the dye eosin. Cells are also differentiated from other granulocytes by a small nuclear-to-cytoplasm ratio (1:3). This cell type is CD49d-positive." [GOC:add, GOC:dsd, GOC:tfm, http://www.cap.org, ISBN:0721601464] comment: Eosinophils are CD125-positive (IL-5R), GM-CSFR-positive, IL-3R-positive, VLA4-positive. They can also express MHC Class I & II, CD4, CD9, CD11a, CD11b, CD11c, CD13, CD15, CD16, CD17, CD18, CD24, CD25,CD28, CD29, CD32, CD33, CD35, CD37, CD39, CD43, CD44, CD45, CD45RB, CD45RO, CD46, CD47, CD48, CD49d, CD49f, CD50, CD52, CD53, CD54, CD55, CD58, CD59, CD62L, CD63, CD65, CD66, CD69, CD71, CD76, CD80, CD81, CD82, CD86, CD87, CD88, CD89, CD92, CD95, CD97, CD98, CD99, CD100, CD101, CD116, CD117, CD119, CD120, CD123, CD124, CD125, CD131, CD137, CD139, CD148, CD149, CD151, CD153, CD156, CD162, CD161, CD162, CD165, CD174, CD182, CD183, CD191, CD192, CD193, CD196, CD213, IL9R, ad integrin, beta-7 integrin, FceRI, IL13Ra1, TGFbR, PAFR, LTB4R, C3aR, CystLT1R, CystLT2R, fMLPR, CRTH2 (PGD2 receptor), histamine 4R, IDO, KYN, PAR-2, Siglec-8, Siglec-10, LIR1, LIR2, LIR3, LIR7, TLR7, TLR8, and VLA-4. Eosinophils can also secrete CXCL1, eotaxin-1, GM-CSF, IL-2, IL-3, IL-4, IL-5, IL-6, IL-8, IL-10, IL-12, IL-13, IL-16, IL-18, IFN-gamma, LTC4, MIP-1alpha, NGF, PAF, RANTES, substance P, TGF-alpha, TGF-beta, TNF-alpha, and VIP. subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "mature eosinocyte" EXACT [] synonym: "mature eosinophil leucocyte" EXACT [] synonym: "mature eosinophil leukocyte" EXACT [] synonym: "polymorphonuclear leucocyte" BROAD [] synonym: "polymorphonuclear leukocyte" BROAD [] is_a: CL:0000145 ! professional antigen presenting cell is_a: CL:0000771 {is_inferred="true"} ! eosinophil relationship: BFO:0000051 PR:000007152 ! has part eosinophil peroxidase relationship: BFO:0000051 PR:000007857 ! has part erythroid transcription factor relationship: BFO:0000051 PR:000007858 ! has part endothelial transcription factor GATA-2 relationship: BFO:0000051 PR:000014046 ! has part non-secretory ribonuclease relationship: BFO:0000051 PR:000014047 ! has part eosinophil cationic protein relationship: BFO:0000051 PR:000022006 ! has part eosinophil granule major basic protein relationship: RO:0002104 PR:000009129 ! has plasma membrane part integrin alpha-4 relationship: RO:0002202 CL:0000774 ! develops from band form eosinophil relationship: RO:0002215 GO:0002495 ! capable of antigen processing and presentation of peptide antigen via MHC class II relationship: RO:0002215 GO:0002540 ! capable of leukotriene production involved in inflammatory response relationship: RO:0002215 GO:0045730 ! capable of respiratory burst property_value: IAO:0000116 "The status of eosinophils as true professional antigen presenting cells is unclear, despite their ability to present exogenous peptides and peptides processed from exogenous proteins (in certain studies) via MHC Class II and activate T cells. Per the equivalence axioms, 'eosinophil' is reasoned to be a subclass of 'professional antigen presenting cell', though the role of eosinophils as such in the body may be limited." xsd:string property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0000042 name: neutrophilic myeloblast def: "A myeloblast committed to the neutrophil lineage. This cell type is GATA-1 positive, C/EBPa-positive, AML-1-positive, c-myb-positive and has low expression of PU.1 transcription factor." [GOC:add, ISBN:0721601464, PMID:12560239, PMID:15514007] comment: These cells are CD11b-negative, CD15-negative, CD16-negative, CD35-negative, CD49d-positive, CD68-positive, lactotransferrin-negative, and fMLP receptor-negative. They are found in the Band 3 fraction. subset: human_subset subset: mouse_subset synonym: "neutrophilic granuloblast" RELATED [] xref: ZFA:0009018 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000834 ! neutrophil progenitor cell is_a: CL:0000835 {is_inferred="true"} ! myeloblast intersection_of: CL:0000835 ! myeloblast intersection_of: BFO:0000051 PR:000001944 ! has part transcription factor PU.1 intersection_of: BFO:0000051 PR:000005307 ! has part CCAAT/enhancer-binding protein alpha intersection_of: BFO:0000051 PR:000007857 ! has part erythroid transcription factor intersection_of: BFO:0000051 PR:000010799 ! has part myb proto-oncogene protein intersection_of: BFO:0000051 PR:000014362 ! has part runt-related transcription factor 1 intersection_of: RO:0002215 GO:0030223 ! capable of neutrophil differentiation relationship: BFO:0000051 PR:000001944 ! has part transcription factor PU.1 relationship: BFO:0000051 PR:000005307 ! has part CCAAT/enhancer-binding protein alpha relationship: BFO:0000051 PR:000007857 ! has part erythroid transcription factor relationship: BFO:0000051 PR:000010799 ! has part myb proto-oncogene protein relationship: BFO:0000051 PR:000014362 ! has part runt-related transcription factor 1 relationship: RO:0002202 CL:0000834 ! develops from neutrophil progenitor cell [Term] id: CL:0000043 name: mature basophil alt_id: CL:0000739 def: "A fully differentiated basophil, a granular leukocyte with an irregularly shaped, pale-staining nucleus that is partially constricted into two lobes, and with cytoplasm that contains coarse granules of variable size. Basophils contain vasoactive amines such as histamine and serotonin, which are released on appropriate stimulation." [GOC:add, GOC:dsd, GOC:tfm, http://www.cap.org, ISBN:0721601464, PMID:18466030, PMID:19231594, PMID:20837449] comment: Mature basophils are also capable of producing IL-3, IL-5, IL-6, IL-8, IL-13, IL-25, CCL22, tslp, vegf, and LTC4. subset: human_subset subset: mouse_subset synonym: "mature basophil leucocyte" EXACT [] synonym: "mature basophil leukocyte" EXACT [] synonym: "polymorphonuclear leucocyte" BROAD [] synonym: "polymorphonuclear leukocyte" BROAD [] xref: BTO:0001026 xref: CALOHA:TS-0688 is_a: CL:0000767 {is_inferred="true"} ! basophil is_a: CL:0002274 ! histamine secreting cell relationship: RO:0002202 CL:0000770 ! develops from band form basophil relationship: RO:0002215 GO:0002349 ! capable of histamine production involved in inflammatory response relationship: RO:0002215 GO:0002351 ! capable of serotonin production involved in inflammatory response relationship: RO:0002215 GO:0002830 ! capable of positive regulation of type 2 immune response relationship: RO:0002215 GO:0032616 ! capable of interleukin-13 production relationship: RO:0002215 GO:0032633 ! capable of interleukin-4 production relationship: RO:0002215 GO:0048295 ! capable of positive regulation of isotype switching to IgE isotypes [Term] id: CL:0000045 name: obsolete thymus processed stem cell def: "OBSOLETE (was not defined before being made obsolete)." [] comment: Consider using term 'pro-T cell ; CL:0000827' or the term 'thymocyte ; CL:0000893' or one of its children instead. is_obsolete: true [Term] id: CL:0000046 name: obsolete bursa processed stem cell def: "OBSOLETE (was not defined before being made obsolete)." [] comment: Consider using term 'pro-B cell ; CL:0000826' or the term 'immature B cell ; CL:0000816 or one of its children instead. is_obsolete: true [Term] id: CL:0000047 name: neural stem cell def: "An undifferentiated neural cell that originates from the neuroectoderm and has the capacity both to perpetually self-renew without differentiating and to generate multiple central nervous system neuronal and glial cell types." [PMID:30639325] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "neuronal stem cell" EXACT [PMID:16305818] synonym: "NSC" EXACT [] xref: BTO:0002881 xref: CALOHA:TS-2360 xref: FMA:86684 xref: ZFA:0009019 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: BFO:0000002 is_a: CL:0002319 ! neural cell relationship: RO:0002202 CL:0000133 ! develops from neurectodermal cell [Term] id: CL:0000048 name: multi fate stem cell def: "A stem cell that can give rise to multiple lineages of cells." [GOC:add] subset: human_subset subset: mouse_subset synonym: "multi-fate stem cell" EXACT [] synonym: "multifate stem cell" EXACT [] synonym: "multipotent cell" EXACT [] synonym: "multipotent stem cell" EXACT [] xref: FMA:84789 xref: ZFA:0009020 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000034 ! stem cell intersection_of: CL:0000000 ! cell intersection_of: RO:0000053 PATO:0001402 ! has characteristic multipotent intersection_of: RO:0002215 GO:0017145 ! capable of stem cell division relationship: RO:0000053 PATO:0001402 ! has characteristic multipotent property_value: skos:prefLabel "multi fate stem cell" xsd:string [Term] id: CL:0000049 name: common myeloid progenitor def: "A progenitor cell committed to myeloid lineage, including the megakaryocyte and erythroid lineages." [GOC:add, ISBN:0878932437, MESH:D023461] comment: This cell type is intended to be compatible with any vertebrate common myeloid progenitor. For mammalian CMP known to be CD34-positive, please use the term 'common myeloid progenitor, CD34-positive' (CL_0001059). subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "CFU-GEMM" RELATED OMO:0003000 [ISBN:0878932437] synonym: "CFU-S" RELATED OMO:0003000 [ISBN:0878932437] synonym: "CMP" RELATED OMO:0003000 [ISBN:0878932437] synonym: "colony forming unit granulocyte, erythrocyte, macrophage, and megakaryocyte" RELATED [ISBN:0878932437] synonym: "common myeloid precursor" EXACT [] synonym: "multipotential myeloid stem cell" RELATED [ISBN:0878932437] synonym: "myeloid stem cell" RELATED [ISBN:0878932437] synonym: "pluripotent stem cell (bone marrow)" RELATED [ISBN:0878932437] xref: BTO:0004730 xref: ZFA:0009021 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0002032 {is_inferred="true"} ! hematopoietic oligopotent progenitor cell disjoint_from: CL:0000050 ! megakaryocyte-erythroid progenitor cell disjoint_from: CL:0000051 ! common lymphoid progenitor disjoint_from: CL:0000557 ! granulocyte monocyte progenitor cell property_value: RO:0002175 NCBITaxon:9606 property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0000049" xsd:string {name="common myeloid progenitor on CELLxGENE CellGuide"} property_value: skos:prefLabel "common myeloid progenitor" xsd:string property_value: terms:description "The common myeloid progenitor (CMP) is a multipotent cell that serves as a crucial intermediary within the overall framework of hematopoietic cell differentiation, which is the process of blood cell production. This part of the hematopoiesis process leads to the formation of myeloid lineage cells, which includes granulocytes (neutrophils, eosinophils, and basophils), monocytes, erythrocytes (red blood cells), and megakaryocytes (platelet-forming cells). \nThe primary function of common myeloid progenitors is differentiation and proliferation into various types of mature blood cells, thereby providing a critical contribution to maintaining homeostasis within the body's immune and circulatory systems. Single-cell analyses have shown that the CMP cell population is heterogeneous with at least two distinct subpopulations, characterized by different cell surface markers and likely already committed to downstream differentiation into either the granulocyte/macrophage lineage or the megakaryocyte/erythrocyte lineage-restricted progenitor. \nThe destiny of a CMP is influenced by numerous cytokines and growth factors in its environment that promote differentiation along specific lineages. For example, IL-3 and GM-CSF stimulate the production of eosinophils, which are essential for the body’s defense against allergens and help fight fungal and parasitic infections. \nBy being able to differentiate into a wide range of different immune cells, common myeloid progenitors play a crucial role in the body's ability to respond to injuries, infections, and other physiological challenges.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1038/35004599", xref="DOI:10.1038/ni.3412", xref="DOI:10.1111/j.1600-065X.2010.00963.x", xref="DOI:10.7554/eLife.60939", xref="https://www.sciencedirect.com/topics/engineering/myeloid-progenitor-cell"} [Term] id: CL:0000050 name: megakaryocyte-erythroid progenitor cell def: "A progenitor cell committed to the megakaryocyte and erythroid lineages." [GOC:add, GOC:dsd, GOC:tfm, http://en.wikipedia.org/wiki/Megakaryocyte-erythroid_progenitor_cell, MESH:D055015, PMID:16647566] comment: MEPs are reportedly CD19-negative, CD34-negative, CD45RA-negative, CD110-positive, CD117-positive, and SCA1-negative and reportedly express the transcription factors GATA-1 and NF-E2. subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "CFU-EM" EXACT [] synonym: "CFU-MegE" EXACT [] synonym: "colony forming unit erythroid megakaryocyte" EXACT [] synonym: "Meg/E progenitor" EXACT [] synonym: "megakaryocyte/erythrocyte progenitor" EXACT [] synonym: "megakaryocyte/erythroid progenitor cell" EXACT [] synonym: "MEP" EXACT [] xref: ZFA:0009022 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000763 ! myeloid cell is_a: CL:0002032 {is_inferred="true"} ! hematopoietic oligopotent progenitor cell is_a: CL:0011026 ! progenitor cell intersection_of: CL:0002032 ! hematopoietic oligopotent progenitor cell intersection_of: RO:0002215 GO:0030218 ! capable of erythrocyte differentiation intersection_of: RO:0002215 GO:0030219 ! capable of megakaryocyte differentiation disjoint_from: CL:0000557 ! granulocyte monocyte progenitor cell disjoint_from: CL:0002009 ! macrophage dendritic cell progenitor relationship: RO:0002215 GO:0030218 ! capable of erythrocyte differentiation relationship: RO:0002215 GO:0030219 ! capable of megakaryocyte differentiation property_value: RO:0002175 NCBITaxon:9606 property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0000050" xsd:string {name="megakaryocyte-erythroid progenitor cell on CELLxGENE CellGuide"} property_value: skos:prefLabel "megakaryocyte-erythroid progenitor cell" xsd:string property_value: terms:description "The megakaryocyte-erythroid progenitor (MEP) cell belongs to the multipotent hematopoietic progenitor cells, which can give rise to multiple different cell types. They are found in the bone marrow, the primary organ where new blood cells are generated. MEPs are specially programmed to develop into two distinct blood cell lineages, namely megakaryocytes, which go on to produce platelets for blood clotting, and the erythroid lineage which consists of red blood cells responsible for oxygen transport in the body.\nThe MEP cells are the result of a decision-making process within the hematopoietic stem cell population. Hematopoietic stem cell can differentiate into multiple types of progenitor cells, including myeloid progenitor cells. A further subdivision within this myeloid lineage generates the MEP cells. Therefore, these megakaryocyte-erythroid progenitors represent a key juncture between hematopoietic stem cells and mature blood cell types in the myeloid lineage.\nMegakaryocyte-erythroid progenitor cells play a crucial role in the homeostasis of some of the most crucial constituents of blood. The megakaryocytes produced from these bipotent progenitor cells contribute to hemostasis by producing platelets - small anucleated fragments that are pivotal for blood clotting and preventing bleeding. Similarly, the erythroid lineage from MEP cells gives rise to erythrocytes, which harbor hemoglobin, the molecule that transports oxygen from lungs to every nook and corner of the body. An imbalance or malfunction in MEP function thus can significantly impact human health, leading to diseases like thrombocytopenia or anemia.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1002/stem.2834", xref="DOI:10.1016/j.celrep.2018.10.084", xref="DOI:10.1097/MOH.0000000000000625", xref="DOI:10.1161/ATVBAHA.119.312129", xref="DOI:10.1182/blood-2016-01-693705"} [Term] id: CL:0000051 name: common lymphoid progenitor alt_id: CL:0000044 def: "A oligopotent progenitor cell committed to the lymphoid lineage." [GOC:add, GOC:dsd, GOC:tfm, PMID:10407577, PMID:16551251] comment: CLP are CD7-positive, CD10-positive, CD19-negative, CD34-positive, CD45RA-positive, CD79a-negative, CD127-positive, AA4.1-positive, RAG-negative, Sca-1-low, sIgM-negative, sIgD-negative, TdT-negative, Vpre-B-negative, and pre-BCR-negative. Expression of transcription factors include E2A-positive, EBF-positive, Ikaros-negative, PU.1-negative, and Pax5-negative. subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "CLP" RELATED OMO:0003000 [] synonym: "committed lymphopoietic stem cell" RELATED [] synonym: "common lymphocyte precursor" EXACT [] synonym: "common lymphocyte progenitor" EXACT [] synonym: "common lymphoid precursor" EXACT [] synonym: "early lymphocyte progenitor" RELATED [] synonym: "ELP" RELATED OMO:0003000 [] synonym: "lymphoid stem cell" RELATED [] synonym: "lymphopoietic stem cell" RELATED [] xref: ZFA:0009023 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0002032 {is_inferred="true"} ! hematopoietic oligopotent progenitor cell is_a: CL:0011026 ! progenitor cell intersection_of: CL:0002032 ! hematopoietic oligopotent progenitor cell intersection_of: RO:0002215 GO:0030098 ! capable of lymphocyte differentiation relationship: RO:0002215 GO:0030098 ! capable of lymphocyte differentiation property_value: RO:0002175 NCBITaxon:9606 property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0000051" xsd:string {name="common lymphoid progenitor on CELLxGENE CellGuide"} property_value: terms:description "The common lymphoid progenitor (CLP) arises from the multipotential hematopoietic stem cell in the bone marrow. Hematopoietic stem cells have the unique capability of developing into any type of blood cell depending on the body's requirements. In contrast, common lymphoid progenitors are already committed to the lymphoid lineage but are still oligopotent with the capability to further differentiate into various types of lymphoid cells. \nIn mice, cells in the common lymphoid progenitor population in the bone marrow can be identified by their Lin- IL7rα+ c-Kit+ Sca-1+ cell surface phenotype. The IL-7 receptor is first expressed on common lymphoid progenitor cells and distinguishes them from primitive common myeloid progenitors, and IL-7 is thought to play a critical role in the downstream development and homeostasis of immune cells.\nCLPs give rise to B lymphocytes, T lymphocytes, dendritic cells, and natural killer cells, all of which play a crucial and distinct role in immune responses. B and T lymphocytes are responsible for adaptive immunity, allowing the body to recognize and remember specific pathogens to fight them off more effectively in the future. B lymphocytes are responsible for producing antibodies, while T lymphocytes either help regulate immune responses or directly kill infected cells. Natural Killer cells are part of the body’s innate immune response, providing immediate, nonspecific defense against pathogens. They are able to interact with infected or malignant cells and induce controlled cell death, or apoptosis, effectively eliminating the threat to bodily health. Dendritic cells link the innate and adaptive immune systems by presenting antigens to T cells, promoting an adaptive response.\nThus, common lymphoid progenitors provide the basis for the body's strategic and layered defense against varied and evolving external threats, making them an essential part of the immune system.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1016/s0092-8674(00)80453-5", xref="DOI:10.1038/ni.3168", xref="DOI:10.1111/j.1600-065X.2010.00963.x", xref="DOI:10.1182/blood-2009-08-236398", xref="DOI:10.3389/fimmu.2021.747324"} [Term] id: CL:0000052 name: totipotent stem cell def: "A stem cell from which all cells of the body can form." [GOC:add, GOC:tfm] subset: human_subset subset: mouse_subset synonym: "totipotential stem cell" EXACT [] xref: FMA:84790 xref: MESH:D039901 xref: ZFA:0009024 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000723 ! somatic stem cell property_value: skos:prefLabel "totipotent stem cell" xsd:string [Term] id: CL:0000054 name: obsolete bone matrix secreting cell comment: synonymous with 'osteoblast' property_value: IAO:0000233 https://github.com/obophenotype/cell-ontology/issues/2698 is_obsolete: true replaced_by: CL:0000062 [Term] id: CL:0000055 name: obsolete non-terminally differentiated cell def: "OBSOLETE. A precursor cell with a limited number of potential fates." [SANBI:mhl] comment: Redundant grouping term define using PATO mulit-potent or oligopotent? synonym: "blast cell" EXACT [] xref: BTO:0000125 xref: FMA:84782 property_value: IAO:0000233 "https://github.com/obophenotype/cell-ontology/issues/2922" xsd:string is_obsolete: true consider: CL:0011026 [Term] id: CL:0000056 name: myoblast def: "A cell that is commited to differentiating into a muscle cell. Embryonic myoblasts develop from the mesoderm. They undergo proliferation, migrate to their various sites, and then differentiate into the appropriate form of myocytes. Myoblasts also occur as transient populations of cells in muscles undergoing repair." [GOC:tfm, MESH:D032446, PMID:21849021] subset: cellxgene_subset subset: human_subset subset: mouse_subset xref: BTO:0000222 xref: CALOHA:TS-0650 xref: FBbt:00005083 {sssom:mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"} xref: FMA:70335 xref: VHOG:0001529 xref: ZFA:0009025 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000680 ! muscle precursor cell property_value: skos:prefLabel "myoblast" xsd:string [Term] id: CL:0000057 name: fibroblast def: "A connective tissue cell which secretes an extracellular matrix rich in collagen and other macromolecules. Flattened and irregular in outline with branching processes; appear fusiform or spindle-shaped." [http://en.wikipedia.org/wiki/Fibroblast, ISBN:0517223651, MESH:D005347] comment: These cells may be vimentin-positive, fibronectin-positive, fsp1-positive, MMP-1-positive, collagen I-positive, collagen III-positive, and alpha-SMA-negative. subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset xref: BTO:0000452 xref: CALOHA:TS-0362 xref: FMA:63877 xref: NCIT:C12482 xref: VHOG:0001482 xref: ZFA:0009026 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000499 ! stromal cell property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "fibroblast" xsd:string [Term] id: CL:0000058 name: chondroblast def: "Skeletogenic cell that is typically non-terminally differentiated, secretes an avascular, GAG rich matrix; is not buried in cartilage tissue matrix, retains the ability to divide, located adjacent to cartilage tissue (including within the perichondrium), and develops from prechondroblast (and thus prechondrogenic) cell." [GO_REF:0000034, GOC:tfm, ISBN:0618947256] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "chrondoplast" EXACT [] xref: BTO:0003607 xref: FMA:66783 xref: ZFA:0009027 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0002320 ! connective tissue cell is_a: CL:0011026 ! progenitor cell relationship: RO:0002202 CL:0007009 ! develops from prechondroblast relationship: RO:0003000 UBERON:0002418 ! produces cartilage tissue property_value: skos:prefLabel "chondroblast" xsd:string [Term] id: CL:0000059 name: ameloblast alt_id: CL:0000053 alt_id: CL:0000139 def: "Skeletogenic cell that produces enamel, overlies the odontogenic papilla, and arises from the differentiation of a preameloblast cell." [GO_REF:0000034, GOC:tfm, MESH:D000565] comment: non-encoded relationship from VSAO produces VSAO:0000066 subset: human_subset subset: mouse_subset synonym: "amelocyte" EXACT [] synonym: "enamel secreting cell" EXACT [] xref: BTO:0001663 xref: FMA:70576 is_a: CL:0000146 ! simple columnar epithelial cell is_a: CL:0002077 ! ecto-epithelial cell is_a: CL:1100001 ! secretory epithelial cell relationship: BFO:0000050 UBERON:0005176 ! part of tooth enamel organ relationship: RO:0002202 CL:0007000 ! develops from preameloblast relationship: RO:0002215 GO:0097186 ! capable of amelogenesis relationship: RO:0002220 UBERON:0001763 ! adjacent to odontogenic papilla relationship: RO:0003000 UBERON:0001752 ! produces enamel [Term] id: CL:0000060 name: odontoblast def: "Skeletogenic cell that secretes dentine matrix, is derived from the odontogenic papilla, and develops from a preodontoblast cell." [GO_REF:0000034, ISBN:0618947256] comment: legacy def: One of the cells forming the outer surface of dental pulp that produces tooth dentin. subset: cellxgene_subset subset: human_subset subset: mouse_subset xref: BTO:0001769 xref: CALOHA:TS-0696 xref: FMA:62999 xref: MESH:D009804 xref: ZFA:0009029 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000710 ! neurecto-epithelial cell is_a: CL:0002148 ! dental pulp cell relationship: BFO:0000050 UBERON:0005176 ! part of tooth enamel organ relationship: RO:0002202 CL:0007003 ! develops from preodontoblast relationship: RO:0003000 UBERON:0001751 ! produces dentine [Term] id: CL:0000061 name: cementoblast alt_id: CL:0000859 def: "Skeletogenic cell that produces cementum (a bony substance that covers the root of a tooth), is part of the odontogenic papilla, and develops from a precementoblast cell." [GO_REF:0000034, ISBN:0781733901] comment: Legacy def: A cell of ectomesenchymal origin that aids in the formation the cementum layer on the roots of teeth. subset: human_subset subset: mouse_subset synonym: "cementum secreting cell" EXACT [] xref: CALOHA:TS-1164 xref: FMA:63002 xref: ZFA:0009030 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000062 ! osteoblast is_a: CL:0000151 ! secretory cell relationship: BFO:0000050 UBERON:0005176 ! part of tooth enamel organ relationship: RO:0002202 CL:0007002 ! develops from precementoblast relationship: RO:0003000 UBERON:0001753 ! produces cementum [Term] id: CL:0000062 name: osteoblast def: "Skeletogenic cell that secretes osteoid, is capable of producing mineralized (hydroxyapatite) matrix, is located adjacent to or within osteoid tissue, and arises from the transformation of a preosteoblast cell." [GO_REF:0000034, MESH:D010006] comment: non-encoded relationships from VSAO - capable_of_producing VSAO:0000020 subset: cellxgene_subset subset: human_subset subset: mouse_subset xref: BTO:0001593 xref: CALOHA:TS-0720 xref: FMA:66780 xref: ZFA:0009031 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: BFO:0000002 is_a: CL:0002320 ! connective tissue cell relationship: RO:0002202 CL:0007010 ! develops from preosteoblast relationship: RO:0003000 UBERON:0008883 ! produces osteoid property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0000062" xsd:string {name="osteoblast on CELLxGENE CellGuide"} property_value: terms:description "Osteoblasts are a type of bone cell primarily responsible for bone formation. Osteoblasts are derived from mesenchymal stem cells, which differentiate into osteoblasts under the influence of various growth factors, including bone morphogenetic proteins (BMPs). These multipotent cells play a critical role in the bone formation process known as ossification.\nThe primary function of osteoblasts is to synthesize and deposit bone matrix, a mixture of organic substances and inorganic materials. This included producing a mix of collagen and non-collagenous proteins, which they secrete to create the organic portion of the extracellular bone matrix. The osteoblasts also initiate the mineralization process by depositing calcium and phosphate ions onto this organic matrix, generating a material that is incredibly strong and resilient, which we recognize as bone. \nFurthermore, osteoblasts are intricately involved in bone remodeling. They communicate with other specialized bone cells, like osteoclasts (involved in bone resorption) and osteocytes (derived from osteoblasts and important for bone maintenance), helping to maintain skeletal health and homeostasis. Dysregulation of osteoblast function can lead to various bone diseases, illustrating the importance of these cells in skeletal health and development.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1038/nrm3254", xref="DOI:10.1038/s41574-019-0246-y", xref="DOI:10.1038/s41580-020-00279-w", xref="DOI:10.1089/ten.teb.2016.0454", xref="DOI:10.3390/ijms19020360"} [Term] id: CL:0000063 name: obsolete cell by histology def: "OBSOLETE: A classification of cells by their microscopic appearance." [FB:ma, GOC:tfm] comment: This term was made obsolete because there is no difference in meaning between it and 'cell', as any cell can be classified by its microscopic appearance. If you have used this term in annotation, please replace it with cell (CL:0000000), native cell (CL:0000003), or cell in vitro (CL:0001034) as appropriate. is_obsolete: true consider: CL:0000000 consider: CL:0000003 consider: CL:0001034 [Term] id: CL:0000064 name: ciliated cell def: "A cell that has a filiform extrusion of the cell surface." [GOC:tfm] subset: cellxgene_subset subset: human_subset subset: mouse_subset xref: VHOG:0001532 xref: XAO:0000031 xref: ZFA:0009032 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000255 ! eukaryotic cell intersection_of: CL:0000000 ! cell intersection_of: BFO:0000051 GO:0005929 ! has part cilium relationship: BFO:0000051 GO:0005929 ! has part cilium property_value: skos:prefLabel "ciliated cell" xsd:string [Term] id: CL:0000065 name: ependymal cell def: "A neuroepithelial glial cell, derived from a radial glial cell originating from the neuroectoderm, lines the ventricles of the brain and the central canal of the spinal cord. This cell is characterized by the presence of cilia on its apical surface, which can be motile or non-motile." [doi:/10.3389/fncel.2021.703951, GOC:tfm, https://www.britannica.com/science/ependymal-cell, JB:jb, PMID:34335193, PMID:37008045, PMID:9550134] subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "ependymocyte" NARROW [doi:10.53347/rID-51713] xref: BTO:0001724 xref: FMA:70550 xref: ZFA:0009033 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000067 ! ciliated epithelial cell is_a: CL:0000125 ! glial cell is_a: CL:0000710 ! neurecto-epithelial cell intersection_of: CL:0000066 ! epithelial cell intersection_of: BFO:0000050 UBERON:0004670 ! part of ependyma relationship: BFO:0000050 UBERON:0004670 ! part of ependyma relationship: RO:0002207 CL:0000681 ! directly develops from radial glial cell property_value: RO:0002175 NCBITaxon:9606 property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0000065" xsd:string {name="ependymal cell on CELLxGENE CellGuide"} property_value: skos:prefLabel "ependymal cell" xsd:string property_value: terms:description "Ependymal cells are ciliated neuroepithelial cells lining the ventricles of the brain and the central canal of the spinal cord, forming a single-layered epithelium, known as the ependyma. Together with astrocytes, microglial cells, and oligodendrocytes, they are one of the four main types of neuroglia found in the nervous system. \nEpendymal cells are equipped with multiple functions that support the brain and spinal cord. Key amongst these functions are the secretion, circulation, and absorption of cerebrospinal fluid, which cushions the brain, distributes neuroendocrine factors, and disposes of neural waste. The cilia on the apical surface of ependymal cells vigorously beat in a coordinated fashion to circulate the cerebrospinal fluid. Additionally, these cells may also function in aiding the migration of neuroblasts during brain development.\nEpendymal cells form a barrier between the cerebrospinal fluid and the adjacent nervous tissue in the central nervous system, which appears to be particularly important during development. In response to injury, ependymal cells have been observed to proliferate and have the potential to transform into astrocytes or oligodendrocytes, suggesting stem cell-like functions.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1007/s00401-009-0624-y", xref="DOI:10.14336/AD.2022.0826-1", xref="DOI:10.4161/tisb.28426"} [Term] id: CL:0000066 name: epithelial cell def: "A cell that is usually found in a two-dimensional sheet with a free surface. The cell has a cytoskeleton that allows for tight cell to cell contact and for cell polarity where apical part is directed towards the lumen and the basal part to the basal lamina." [FB:ma, GOC:tfm, MESH:D004847] subset: cellxgene_subset subset: general_cell_types_upper_slim subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "epitheliocyte" EXACT [] xref: BTO:0000414 xref: CALOHA:TS-2026 xref: CARO:0000077 xref: FBbt:00000124 {sssom:mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"} xref: FMA:66768 xref: WBbt:0003672 xref: ZFA:0009034 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000255 ! eukaryotic cell disjoint_from: CL:0000738 ! leukocyte relationship: BFO:0000050 UBERON:0000483 ! part of epithelium property_value: foaf:depiction "https://www.swissbiopics.org/api/image/Epithelial_cells.svg" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "epithelial cell" xsd:string [Term] id: CL:0000067 name: ciliated epithelial cell def: "An epithelial cell that has a cilia." [GOC:tfm] subset: cellxgene_subset subset: human_subset subset: mouse_subset xref: FMA:70605 xref: ZFA:0009035 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000064 ! ciliated cell is_a: CL:0000066 ! epithelial cell intersection_of: CL:0000066 ! epithelial cell intersection_of: BFO:0000051 GO:0005929 ! has part cilium property_value: skos:prefLabel "ciliated epithelial cell" xsd:string [Term] id: CL:0000068 name: duct epithelial cell def: "An epithelial cell that is part of a duct." [https://orcid.org/0000-0001-5208-3432] subset: cellxgene_subset subset: human_subset subset: mouse_subset xref: ZFA:0009372 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000066 ! epithelial cell intersection_of: CL:0000066 ! epithelial cell intersection_of: BFO:0000050 UBERON:0000058 ! part of duct relationship: BFO:0000050 UBERON:0000058 ! part of duct property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0000068" xsd:string {name="duct epithelial cell on CELLxGENE CellGuide"} property_value: terms:description "Duct epithelial cells are distinctly specialized cells that predominantly form the lining of glandular ducts. These cells play a crucial role in the secretion, absorption, and transport of fluids depending on the organ they inhabit. They are typically organized in a tubular structure, forming collectively the conduit for the transport of substances. These cells exhibit tight junctions, enabling the careful regulation of the passage of substances and ensuring that no unwanted particles seep through. They are predominantly characterized by their polarized nature, having distinct apical and basolateral surfaces that support its functions of secretion and absorption. The apical surface, exposed to the duct lumen, is specialized for secretion and interaction with the luminal environment, while the basolateral surface is oriented towards the underlying tissue, facilitating interactions with neighboring cells and the extracellular matrix.\nThe ducts serve as the bridge between the gland and the site of secretion, allowing the substances produced by the gland to exit into the body. Thus, duct epithelial cells have a sweeping role in various physiological functions, ranging from defense against pathogens in the respiratory and digestive tracts, to secretion of digestive enzymes, to milk production in mammary glands.\nAs a result of their specialized function, any impairment in the function of duct epithelial cells to function properly often leads to certain diseases or disorders. Studies have identified potential correlation between malfunctioning duct epithelial cells and conditions such as cystic fibrosis, chronic obstructive pulmonary disease, and certain cancers, particularly breast and pancreatic.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1038/s41467-018-04334-1", xref="DOI:10.1513/AnnalsATS.201402-049AW", xref="DOI:10.3389/fphar.2019.00074", xref="DOI:10.4161/tisb.25718", xref="https://www.sciencedirect.com/topics/medicine-and-dentistry/mammary-epithelium"} [Term] id: CL:0000069 name: branched duct epithelial cell subset: human_subset subset: mouse_subset is_a: CL:0000068 ! duct epithelial cell [Term] id: CL:0000070 name: obsolete epithelial cell of gland is_obsolete: true [Term] id: CL:0000071 name: blood vessel endothelial cell def: "An endothelial cell that lines the vasculature." [GOC:tfm] subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset xref: ZFA:0009036 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0002139 ! endothelial cell of vascular tree intersection_of: CL:0000115 ! endothelial cell intersection_of: BFO:0000050 UBERON:0001981 ! part of blood vessel relationship: BFO:0000050 UBERON:0004638 ! part of blood vessel endothelium property_value: RO:0002175 NCBITaxon:9606 property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0000071" xsd:string {name="blood vessel endothelial cell on CELLxGENE CellGuide"} property_value: skos:prefLabel "blood vessel endothelial cell" xsd:string property_value: terms:description "Blood vessel endothelial cells, also known as vascular endothelial cells, form the delicate inner lining of the complex circulatory system, including arteries and veins. These cells form a single, continuous monolayer inside every blood vessel, acting as a crucial biomolecular barrier between the blood, and the rest of the body tissues. They perform various fundamental biological functions, ranging from maintenance of vessel integrity to blood clotting regulation. Additionally, they control the transportation of fluids, molecules, and blood particulate matter from and into the bloodstream.\nOne of the primary functions of blood vessel endothelial cells is to maintain vascular homeostasis - a stable environment within the blood vessels. They accomplish this through several methods: they control vasomotor tone, i.e. the degree of contraction and dilation of blood vessels, by secreting vasoactive substances such as nitric oxide and endothelin; mediate responses to inflammatory stimuli; and they also regulate angiogenesis, the process of new blood vessel formations. Blood vessel endothelial cells play a significant role in preventing blood clot formation by generating a slick, non-thrombogenic surface that disallows platelets or coagulant proteins from adhering to it.\nBlood vessel endothelial cells are sensitive to various stimuli, including shear stress caused by blood flow, and they can respond by altering their morphology, function, and gene expression. This ability to adapt enables blood vessels to remodel and ensure the adequate delivery of nutrients and oxygen to all tissues, regardless of physiological demand variations. Conversely, endothelial dysfunction, often associated with a reduction in the bioavailability of endothelium-derived nitric oxide, can lead to the development of pathological conditions such as atherosclerosis, hypertension, diabetes mellitus, and even aging-related diseases.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1007/s00441-021-03471-2", xref="DOI:10.1016/j.biomaterials.2007.01.039", xref="DOI:10.1038/s41569-022-00770-1", xref="DOI:10.1152/physrev.00001.2017", xref="DOI:10.3390/ijms20184411"} [Term] id: CL:0000072 name: non-branched duct epithelial cell subset: human_subset subset: mouse_subset is_a: CL:0000068 ! duct epithelial cell is_a: CL:0002078 ! meso-epithelial cell [Term] id: CL:0000073 name: obsolete barrier epithelial cell property_value: IAO:0000233 https://github.com/obophenotype/cell-ontology/issues/1149 is_obsolete: true replaced_by: CL:0000215 [Term] id: CL:0000074 name: obsolete epithem cell def: "Obsolete. Use PO:0000066 from Plant Ontology instead. A cell that constitutes the mesophyll of a hydathode and is located between the xylem endings and the epidermis. Proposed to be involved in the retrieval of solutes from the xylem sap." [ISBN:0471245208, PMID:12662305] is_obsolete: true replaced_by: PO:0000066 [Term] id: CL:0000075 name: columnar/cuboidal epithelial cell def: "A columnar/cuboidal epithelial cell is a cell usually found in a two dimensional sheet with a free surface. Columnar/cuboidal epithelial cells take on the shape of a column or cube." [GO:0002065, https://orcid.org/0000-0001-5208-3432] subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset xref: ZFA:0009038 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000066 ! epithelial cell property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "columnar/cuboidal epithelial cell" xsd:string [Term] id: CL:0000076 name: squamous epithelial cell subset: cellxgene_subset subset: human_subset subset: mouse_subset xref: CALOHA:TS-1249 xref: ZFA:0009039 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000066 ! epithelial cell property_value: skos:prefLabel "squamous epithelial cell" xsd:string [Term] id: CL:0000077 name: mesothelial cell def: "A flat, squamous-like epithelial cell of mesodermal origin. It forms the mesothelium, which lines the body's serous cavities including the pleural, peritoneal, and pericardial spaces. This cell plays a crucial role in synthesizing and secreting lubricants, such as glycosaminoglycans and surfactants, which minimize friction between adjacent tissues during movement." [GOC:tfm, ISBN:0721662544, PMID:26106328] comment: Mesothelial cells, which morphologically resemble squamous epithelial cells, express both epithelial markers (cytokeratins) and mesenchymal markers (vimentin), reflecting their mesodermal origin. They feature surface microvilli and apical-basal polarity. Under certain conditions, they can undergo mesothelial-to-mesenchymal transition. These cells also produce extracellular matrix proteins, maintain serosal homeostasis, and facilitate fluid transport. {xref="PMID:26106328"} subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "mesotheliocyte" EXACT [] xref: FMA:66773 xref: ZFA:0009040 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000076 ! squamous epithelial cell is_a: CL:0002078 ! meso-epithelial cell relationship: BFO:0000050 UBERON:0001136 ! part of mesothelium property_value: RO:0002175 NCBITaxon:9606 property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0000077" xsd:string {name="mesothelial cell on CELLxGENE CellGuide"} property_value: terms:description "Mesothelial cells are crucial components of the mesothelium, a protective layer that lines the body's internal cavities, including pleural cavity (around the lungs), the pericardial cavity (around the heart), and the peritoneal cavity (within the abdomen). Derived from the embryonic mesoderm layer, these cells exhibit a squamous-like epithelial morphology, usually appearing as a single layer of flat, pavement-like cells in their healthy state.\nMesothelial cells play a vital role in various physiological processes, such as intraperitoneal immunity, fibrinolysis, tissue repair, and tumor suppression. Their primary function is to provide a slippery, non-adhesive and protective surface to reduce friction and eases the movements of the organs within the pleural, pericardial, and peritoneal cavities, and they participate in the transport and movement of fluid and various molecules across the so-called serosal cavities. \nThese cells have adaptive capabilities that facilitate their role in many pathological processes. In response to injury or inflammation, mesothelial cells can undergo morphological and functional changes, such as mesothelial-mesenchymal transitions, aiding in wound healing and tissue repair. Dysfunctions of mesothelial cells, however, can lead to serious health conditions, including adhesions, fibrosis, and malignancies such as peritoneal and pleural mesotheliomas.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1016/S1357-2725(03)00242-5", xref="DOI:10.1038/s41467-020-16893-3", xref="DOI:10.1046/j.1440-1843.2002.00404.x", xref="DOI:10.3389/fphar.2015.00113"} [Term] id: CL:0000078 name: peridermal cell def: "Any squamous epithelial cell that is part of some periderm." [FBC:Autogenerated] subset: cellxgene_subset subset: human_subset subset: mouse_subset xref: ZFA:0009041 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000076 ! squamous epithelial cell is_a: CL:0000362 ! epidermal cell intersection_of: CL:0000076 ! squamous epithelial cell intersection_of: BFO:0000050 UBERON:0003055 ! part of periderm relationship: BFO:0000050 UBERON:0003055 ! part of periderm [Term] id: CL:0000079 name: stratified epithelial cell def: "An epithelial cell, organized into multiple layers, with only the basal layer being in contact with the basement membrane." [doi:/10.1016/B978-0-12-410424-2.00003-2, https://www.biologyonline.com/dictionary/stratified-epithelium, Wikipedia:Epithelium] subset: cellxgene_subset subset: human_subset subset: mouse_subset xref: ZFA:0009042 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: BFO:0000002 is_a: CL:0000066 ! epithelial cell relationship: RO:0002202 CL:0000357 ! develops from stratified epithelial stem cell property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0000079" xsd:string {name="stratified epithelial cell on CELLxGENE CellGuide"} property_value: terms:description "Stratified epithelial cells form layers of cells stacked on top of one another, and they primarily function as a protective barrier. Their appearance can be cuboidal, columnar or squamous, and they offer a layer of defense against foreign bodies, harmful substances, pathogens, and prevent water loss and electrolyte imbalance within the body. Depending on the organ and its specific function, the topmost layer of these cells may be specialized as keratinized or non-keratinized. The skin, being constantly exposed to external physical stress, is composed of keratinized stratified epithelial cells that prevent desiccation and provide additional protection. In contrast, non-keratinized stratified epithelial cells line internally exposed surfaces like the oral cavity, esophagus, and vagina, where lubrication is required. \nIn addition to protection, stratified epithelial cells also contribute to tissue repair processes, referred to as epithelialization. Basal epithelial cells are capable of rapid division and migration to heal wounds and maintain the protective barrier function of the tissues they line. Despite having a limited lifespan, these cells ensure a constant replacement process, maintaining their population and the integrity of epithelial layers.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1002/wdev.146", xref="https://www.ncbi.nlm.nih.gov/books/NBK534261/"} [Term] id: CL:0000080 name: circulating cell def: "A cell which moves among different tissues of the body, via blood, lymph, or other medium." [GOC:add] subset: human_subset subset: mouse_subset xref: ZFA:0009043 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000255 ! eukaryotic cell intersection_of: CL:0000000 ! cell intersection_of: BFO:0000050 UBERON:0000179 ! part of haemolymphatic fluid relationship: BFO:0000050 UBERON:0000179 ! part of haemolymphatic fluid [Term] id: CL:0000081 name: blood cell def: "A cell found predominately in the blood." [GOC:add, GOC:tfm] subset: cellxgene_subset subset: human_subset subset: mouse_subset xref: FMA:62844 xref: MESH:D001773 xref: ZFA:0009044 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000988 {is_inferred="true"} ! hematopoietic cell intersection_of: CL:0000988 ! hematopoietic cell intersection_of: RO:0002215 GO:0008015 ! capable of blood circulation relationship: RO:0002215 GO:0008015 ! capable of blood circulation property_value: skos:prefLabel "blood cell" xsd:string [Term] id: CL:0000082 name: epithelial cell of lung def: "An epithelial cell of the lung." [https://orcid.org/0000-0001-5208-3432] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "lung epithelial cell" EXACT [] xref: BTO:0004299 is_a: CL:0002632 ! epithelial cell of lower respiratory tract intersection_of: CL:0000066 ! epithelial cell intersection_of: BFO:0000050 UBERON:0000115 ! part of lung epithelium relationship: BFO:0000050 UBERON:0000115 ! part of lung epithelium [Term] id: CL:0000083 name: epithelial cell of pancreas def: "An epithelial cell of the pancreas." [GOC:tfm] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "pancreas epithelial cell" EXACT [] synonym: "pancreatic epithelial cell" EXACT [] xref: BTO:0000028 xref: ZFA:0009045 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0002076 ! endo-epithelial cell intersection_of: CL:0000066 ! epithelial cell intersection_of: BFO:0000050 UBERON:0001264 ! part of pancreas relationship: BFO:0000050 UBERON:0001264 ! part of pancreas [Term] id: CL:0000084 name: T cell alt_id: CL:0000804 alt_id: CL:0000812 def: "A type of lymphocyte whose defining characteristic is the expression of a T cell receptor complex." [GOC:add, GOC:tfm, ISBN:0781735149] subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "immature T cell" RELATED [] synonym: "mature T cell" RELATED [] synonym: "T lymphocyte" EXACT [] synonym: "T-cell" EXACT [] synonym: "T-lymphocyte" EXACT [] xref: BTO:0000782 xref: CALOHA:TS-1001 xref: FMA:62870 xref: MESH:D013601 xref: VHOG:0001479 xref: ZFA:0009046 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000542 {is_inferred="true"} ! lymphocyte intersection_of: CL:0000542 ! lymphocyte intersection_of: RO:0002215 GO:0002456 ! capable of T cell mediated immunity disjoint_from: CL:0000945 ! lymphocyte of B lineage relationship: RO:0002202 CL:0000827 ! develops from pro-T cell relationship: RO:0002215 GO:0002456 ! capable of T cell mediated immunity property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0000085 name: obsolete germ line stem cell (sensu Vertebrata) comment: Obsoleted as there is no need for a term specific for vertebrates. property_value: IAO:0000233 https://github.com/obophenotype/cell-ontology/issues/1935 is_obsolete: true replaced_by: CL:0000014 [Term] id: CL:0000086 name: obsolete germ line stem cell (sensu Nematoda and Protostomia) comment: Obsoleted as there is no need for a term specific for nematods and protostomes. property_value: IAO:0000233 https://github.com/obophenotype/cell-ontology/issues/1935 is_obsolete: true replaced_by: CL:0000014 [Term] id: CL:0000087 name: obsolete male germ line stem cell (sensu Nematoda and Protostomia) comment: Obsoleted as there is no need for a term specific for nematods and protostomes. property_value: IAO:0000233 https://github.com/obophenotype/cell-ontology/issues/1935 is_obsolete: true replaced_by: CL:0000016 [Term] id: CL:0000088 name: obsolete female germ line stem cell (sensu Nematoda and Protostomia) comment: Obsoleted as there is no need for a term specific for nematods and protostomes. property_value: IAO:0000233 https://github.com/obophenotype/cell-ontology/issues/1935 is_obsolete: true replaced_by: CL:0000022 [Term] id: CL:0000089 name: obsolete male germ line stem cell (sensu Vertebrata) comment: Obsoleted as there is no need for a term specific for vertebrates. property_value: IAO:0000233 https://github.com/obophenotype/cell-ontology/issues/1935 is_obsolete: true replaced_by: CL:0000016 [Term] id: CL:0000090 name: obsolete female germ line stem cell (sensu Vertebrata) comment: Obsoleted as there is no need for a term specific for vertebrates. property_value: IAO:0000233 https://github.com/obophenotype/cell-ontology/issues/1935 is_obsolete: true replaced_by: CL:0000022 [Term] id: CL:0000091 name: Kupffer cell def: "A tissue-resident macrophage of the reticuloendothelial system found on the luminal surface of the hepatic sinusoids involved in erythrocyte clearance. Markers include F4/80+, CD11b-low, CD68-positive, sialoadhesin-positive, CD163/SRCR-positive. Irregular, with long processes including lamellipodia extending into the sinusoid lumen, have flattened nucleus with cytoplasm containing characteristic invaginations of the plasma membrane (vermiform bodies); lie within the sinusoid lumen attached to the endothelial surface; derived from the bone marrow, form a major part of the body's mononuclear phagocyte system." [GO_REF:0000031, GOC:add, GOC:tfm, ISBN:0517223651, MESH:D007728, PMID:15771589, PMID:17105582] comment: Markers: Mouse: F4/80+, CD11b-low, CD68+, sialoadhesin+, CD163/SRCR+; role or process: immune, antigen-presentation, clearance of senescent erythrocytes, iron metabolism. Kupffer cells are also reportedly C3aR-positive, CD14-low, CD54-positive, CD88-positive, and CD284-positive. They are also capable of producing IL-1, IL-6, TNF-alpha, nitric oxide, PGD2, PGE2, PGF2alpha, and TXA2. subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "hepatic macrophage" EXACT [] synonym: "littoral cell of hepatic sinusoid" EXACT [] synonym: "liver macrophage" EXACT [] synonym: "macrophagocytus stellatus" EXACT [] synonym: "stellate cell of von Kupffer" EXACT [] synonym: "von Kupffer cell" EXACT [] xref: BTO:0000685 xref: FMA:14656 is_a: CL:0000864 {is_inferred="true"} ! tissue-resident macrophage intersection_of: CL:0000864 ! tissue-resident macrophage intersection_of: RO:0001025 UBERON:0001281 ! located in hepatic sinusoid intersection_of: RO:0002104 PR:000001813 ! has plasma membrane part adhesion G protein-coupled receptor E1 intersection_of: RO:0002104 PR:000001925 ! has plasma membrane part scavenger receptor cysteine-rich type 1 protein M130 intersection_of: RO:0002104 PR:000002064 ! has plasma membrane part macrosialin intersection_of: RO:0002215 GO:0034102 ! capable of erythrocyte clearance intersection_of: RO:0015016 PR:000001012 ! has low plasma membrane amount integrin alpha-M relationship: RO:0001025 UBERON:0001281 ! located in hepatic sinusoid relationship: RO:0002104 PR:000001813 ! has plasma membrane part adhesion G protein-coupled receptor E1 relationship: RO:0002104 PR:000001925 ! has plasma membrane part scavenger receptor cysteine-rich type 1 protein M130 relationship: RO:0002104 PR:000002064 ! has plasma membrane part macrosialin relationship: RO:0002215 GO:0034102 ! capable of erythrocyte clearance relationship: RO:0015016 PR:000001012 ! has low plasma membrane amount integrin alpha-M property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/2d-ftu/liver-liver-lobule/v1.3/assets/2d-ftu-liver-liver-lobule.png" xsd:string {terms:licence="http://creativecommons.org/licenses/by/4.0/", xref="doi:10.48539/HBM889.CJPK.447"} property_value: RO:0002175 NCBITaxon:9606 property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0000091" xsd:string {name="Kupffer cell on CELLxGENE CellGuide"} property_value: terms:description "Kupffer cells are tissue-resident macrophages located in the liver. They are an integral part of the mononuclear phagocyte system and are responsible for the phagocytosis of dead or dying cells, microbes, and other foreign substances. Kupffer cells account for approximately 80-90% of tissue-resident macrophages in the body. They are found within the lumen of liver sinusoids and interface with microbial populations and products.\nThe primary role of Kupffer cells is to maintain homeostasis in the liver. They continuously filter and cleanse the blood that flows through the liver, removing pathogens, endotoxins, particulate matter, aged and dysfunctional red blood cells, and miscellaneous waste products. These cells also play an important role in maintaining iron homeostasis. During the process of phagocytosis, Kupffer cells recycle iron from degraded red blood cells, which is then utilized in the formation of new erythrocytes.\nKupffer cells also play key roles in various immune responses and inflammatory processes. They secrete various types of cytokines and chemokines, which contribute to the activation and mobilization of other immune cells. They can also produce reactive oxygen species and nitric oxide, which have microbicidal actions. Although their activity is essential for host defense, excessive or prolonged activation of Kupffer cells may contribute to hepatic injury, inflammation, and fibrosis.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1002/cphy.c120026", xref="DOI:10.1007/978-1-4939-1311-4_10", xref="DOI:10.1016/j.immuni.2022.08.002", xref="DOI:10.1038/nri.2017.11", xref="DOI:10.1111/j.1478-3231.2006.01342.x"} [Term] id: CL:0000092 name: osteoclast def: "A specialized phagocytic cell associated with the absorption and removal of the mineralized matrix of bone tissue, which typically differentiates from monocytes. This cell has the following markers: tartrate-resistant acid phosphatase type 5-positive, PU.1-positive, c-fos-positive, nuclear factor NF-kappa-B p100 subunit-positive, tumor necrosis factor receptor superfamily member 11A-positive and macrophage colony-stimulating factor 1 receptor-positive." [GO_REF:0000031, GOC:add, GOC:tfm, ISBN:0781735149, PMID:10428500, PMID:15055519, PMID:17380158] comment: Morphology: Highly vesicular; markers: Surface: RANK, cFMS (MCSF receptor); Secreted: cathepsin K and TRAP (tartate resistant acid phosphatase); transcription factors: PU.1, cFOS, MITF, NFkB (p52); role or process: tissue remodelling: bone resorption; lineage: hematopoietic, myeloid. subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "chondroclast" RELATED [] xref: BTO:0000968 xref: CALOHA:TS-0721 xref: FMA:66781 xref: MESH:D010010 xref: ZFA:0009047 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000518 ! phagocyte (sensu Vertebrata) is_a: CL:0000766 {is_inferred="true"} ! myeloid leukocyte is_a: CL:0001035 {is_inferred="true"} ! bone cell intersection_of: CL:0000766 ! myeloid leukocyte intersection_of: BFO:0000050 UBERON:0001474 ! part of bone element intersection_of: BFO:0000051 PR:000001850 ! has part cathepsin K intersection_of: BFO:0000051 PR:000001937 ! has part tartrate-resistant acid phosphatase type 5 intersection_of: BFO:0000051 PR:000001944 ! has part transcription factor PU.1 intersection_of: BFO:0000051 PR:000007597 ! has part protein c-Fos intersection_of: BFO:0000051 PR:000011178 ! has part nuclear factor NF-kappa-B p100 subunit intersection_of: RO:0002104 PR:000001954 ! has plasma membrane part tumor necrosis factor receptor superfamily member 11A intersection_of: RO:0002104 PR:000002062 ! has plasma membrane part macrophage colony-stimulating factor 1 receptor intersection_of: RO:0002215 GO:0045453 ! capable of bone resorption relationship: BFO:0000051 PR:000001850 ! has part cathepsin K relationship: BFO:0000051 PR:000001937 ! has part tartrate-resistant acid phosphatase type 5 relationship: BFO:0000051 PR:000001944 ! has part transcription factor PU.1 relationship: BFO:0000051 PR:000007597 ! has part protein c-Fos relationship: BFO:0000051 PR:000011178 ! has part nuclear factor NF-kappa-B p100 subunit relationship: RO:0002104 PR:000001954 ! has plasma membrane part tumor necrosis factor receptor superfamily member 11A relationship: RO:0002104 PR:000002062 ! has plasma membrane part macrophage colony-stimulating factor 1 receptor relationship: RO:0002202 CL:0000576 ! develops from monocyte relationship: RO:0002215 GO:0045453 ! capable of bone resorption property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0000092" xsd:string {name="osteoclast on CELLxGENE CellGuide"} property_value: terms:description "Osteoclasts, derived from the monocyte/macrophage lineage, play a crucial role in bone remodeling through bone resorption. They are distinguished from other cells by their large size and their unique ability to secrete enzymes and acids that dissolve the calcium phosphate in bone. The formation of osteoclasts is influenced by two primary factors: macrophage colony-stimulating factor (M-CSF) and the ligand-activated receptor (RANKL) of nuclear factor kappa B (NF-κB).\nOsteoclasts also collaborate with osteoblasts, responsible for new bone formation, to maintain bone health and adapt bone structure. Their coordinated actions allow continuous remodeling while preserving overall bone strength and integrity. Imbalances in osteoclast activity can lead to pathological conditions. For example, excessive activity may contribute to diseases like osteoporosis, periprosthetic osteolysis, bone tumors, and Paget's disease. Other the other hand, osteoclast deficiency ca result in conditions like osteopetrosis.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.3389/fmed.2017.00234", xref="DOI:10.37175/stemedicine.v1i4.57", xref="https://www.sciencedirect.com/topics/medicine-and-dentistry/osteoclast"} [Term] id: CL:0000093 name: obsolete osteochondroclast def: "OBSOLETE (was not defined before being made obsolete)." [] comment: Consider using 'osteoclast ; CL:0000092' instead. is_obsolete: true [Term] id: CL:0000094 name: granulocyte def: "A leukocyte with abundant granules in the cytoplasm." [GOC:amm, GOC:tfm, http://en.wikipedia.org/wiki/Granulocyte, MESH:D006098] subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "granular leucocyte" EXACT [] synonym: "granular leukocyte" EXACT [] synonym: "polymorphonuclear leukocyte" EXACT [] xref: BTO:0000539 xref: BTO:0001026 xref: CALOHA:TS-0422 xref: FMA:62854 xref: ZFA:0009048 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000081 ! blood cell is_a: CL:0000766 {is_inferred="true"} ! myeloid leukocyte intersection_of: CL:0000766 ! myeloid leukocyte intersection_of: BFO:0000051 GO:0030141 ! has part secretory granule intersection_of: CL:4030046 PR:000001002 ! lacks_plasma_membrane_part CD19 molecule intersection_of: CL:4030046 PR:000001020 ! lacks_plasma_membrane_part CD3 epsilon intersection_of: CL:4030046 PR:000001024 ! lacks_plasma_membrane_part neural cell adhesion molecule 1 intersection_of: CL:4030046 PR:000001084 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD8 alpha chain intersection_of: RO:0002104 PR:000001012 ! has plasma membrane part integrin alpha-M intersection_of: RO:0002104 PR:000001332 ! has plasma membrane part cell adhesion molecule CEACAM8 intersection_of: RO:0002104 PR:000001969 ! has plasma membrane part urokinase plasminogen activator surface receptor intersection_of: RO:0002215 GO:0008015 ! capable of blood circulation relationship: BFO:0000051 GO:0030141 ! has part secretory granule relationship: CL:4030046 PR:000001002 ! lacks_plasma_membrane_part CD19 molecule relationship: CL:4030046 PR:000001020 ! lacks_plasma_membrane_part CD3 epsilon relationship: CL:4030046 PR:000001024 ! lacks_plasma_membrane_part neural cell adhesion molecule 1 relationship: CL:4030046 PR:000001084 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD8 alpha chain relationship: RO:0002104 PR:000001012 ! has plasma membrane part integrin alpha-M relationship: RO:0002104 PR:000001332 ! has plasma membrane part cell adhesion molecule CEACAM8 relationship: RO:0002104 PR:000001969 ! has plasma membrane part urokinase plasminogen activator surface receptor property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0000095 name: neuron associated cell subset: cellxgene_subset subset: human_subset subset: mouse_subset is_a: BFO:0000002 is_a: CL:0002319 ! neural cell relationship: RO:0002202 CL:0000133 ! develops from neurectodermal cell property_value: skos:prefLabel "neuron associated cell" xsd:string [Term] id: CL:0000096 name: mature neutrophil def: "A fully differentiated neutrophil, a granular leukocyte having a nucleus with three to five lobes connected by slender threads, and cytoplasm containing fine inconspicuous granules and stainable by neutral dyes. They are produced in bone marrow at a rate of 5e10-10e10/day and have a half-life of 6-8 hours. Neutrophils are CD15-positive, CD16-positive, CD32-positive, CD43-positive, CD181-positive, and CD182-positive." [GOC:add, GOC:tfm, http://www.cap.org, MESH:D009504, PMID:11138776, PMID:12560239, PMID:15514007, PMID:7880385] comment: Neutrophils are also capable of secreting GRO-alpha, IL-1beta, IL-1ra, IL-3, IL-12, IP-10, MIG, MIP-1alpha, MIP-1beta, TGF-beta, TNF-alpha, VEGF, and anti-microbial peptides. They can positively influence the chemotaxis of basophils, T-cells, monocytes, macrophages, dendritic cells, and other neutrophils. Neutrophils are also CD35-positive, CD64-positive, CD89-positive, CD184-positive, and fMLP receptor-positive Ly-6G-positive (mouse), TLR2-low, TLR4-low, and lineage-negative (CD2, CD3, CD5, CD9, CD19, CD36, CD49d, CD56, CD61, CD235a (glycophorin-A)). subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "mature neutrocyte" EXACT [] synonym: "mature neutrophil leucocyte" EXACT [] synonym: "mature neutrophil leukocyte" EXACT [] synonym: "mature neutrophilic leucocyte" EXACT [] synonym: "mature neutrophilic leukocyte" EXACT [] synonym: "PMN" EXACT [] synonym: "poly" BROAD [] synonym: "polymorphonuclear leucocyte" BROAD [] synonym: "polymorphonuclear leukocyte" BROAD [] synonym: "polymorphonuclear neutrophil" EXACT [] synonym: "polynuclear neutrophilic leucocyte" EXACT [] synonym: "polynuclear neutrophilic leukocyte" EXACT [] xref: BTO:0003473 xref: ZFA:0009049 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000234 ! phagocyte is_a: CL:0000775 {is_inferred="true"} ! neutrophil relationship: BFO:0000051 CL:0017500 ! has part neutrophillic cytoplasm relationship: BFO:0000051 GO:0070820 ! has part tertiary granule relationship: CL:4030045 PR:000009978 ! lacks_part lactotransferrin relationship: CL:4030045 PR:000010543 ! lacks_part myeloperoxidase relationship: CL:4030045 PR:000010799 ! lacks_part myb proto-oncogene protein relationship: RO:0002104 PR:000001256 ! has plasma membrane part C-X-C chemokine receptor type 1 relationship: RO:0002104 PR:000001257 ! has plasma membrane part C-X-C chemokine receptor type 2 relationship: RO:0002104 PR:000001456 ! has plasma membrane part alpha-(1,3)-fucosyltransferase 4 relationship: RO:0002104 PR:000001483 ! has plasma membrane part low affinity immunoglobulin gamma Fc region receptor III relationship: RO:0002104 PR:000001944 ! has plasma membrane part transcription factor PU.1 relationship: RO:0002104 PR:000007597 ! has plasma membrane part protein c-Fos relationship: RO:0002215 GO:0002536 ! capable of respiratory burst involved in inflammatory response relationship: RO:0002215 GO:0002690 ! capable of positive regulation of leukocyte chemotaxis relationship: RO:0002215 GO:0032637 ! capable of interleukin-8 production property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0000097 name: mast cell def: "A cell that is found in almost all tissues containing numerous basophilic granules and capable of releasing large amounts of histamine and heparin upon activation. Progenitors leave bone marrow and mature in connective and mucosal tissue. Mature mast cells are found in all tissues, except the bloodstream. Their phenotype is CD117-high, CD123-negative, CD193-positive, CD200R3-positive, and FceRI-high. Stem-cell factor (KIT-ligand; SCF) is the main controlling signal of their survival and development." [GOC:add, GOC:dsd, GOC:tfm, ISBN:068340007X, MESH:D008407, PMCID:PMC1312421, PMCID:PMC2855166, PMID:15153310, PMID:16455980, PMID:19671378, PMID:212366338, PMID:9354811] comment: Mast cells are generally integrin beta-7-negative and positive for TLR2, TLR3, TLR4, TLR5, TLR7, TLR9, C3aR, C5aR, CR3, CR4, VEGF, FGF2, and renin. They can express MHC Class I and II on their surface. Activated murine mast cells (IgE+Antigen) were capable of expressing the following co-stimulatory molecules: CD95 (Fas), CD120b, CD137 (4-1BB), CD153 (CD30L), CD154 (CD40L), GITR, ICOSL, OX40L, PD-L1, and PD-L2. Note that there was some mouse strain variation. Mast cells have also been demonstrated to produce bFGF, CCL2, CCL4, CCL5, CCL11, CCL20, CXCL2, CXCL8, CXCL10, GM-CSF, IFN-gamma, IL-1, IL-2, IL-3, IL-8, IL-10, IL-11, IL-12, IL-13, IL-16, IL-25, IL-18, MIP-1, prostaglandin D2, SCF, TGF-beta, TNF-alpha, TSLP, VEGF, and XCL1. They express the transcription factors Transcription factors AP-1, GATA1, MITF, Notch2, PIAS3, PU.1, and STAT5. subset: blood_and_immune_upper_slim subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "histaminocyte" EXACT [] synonym: "labrocyte" EXACT [ISBN:0721601464] synonym: "mastocyte" EXACT [ISBN:0721601464] synonym: "tissue basophil" RELATED [ISBN:068340007X] xref: BTO:0000830 xref: CALOHA:TS-0603 xref: FMA:66784 is_a: CL:0000766 {is_inferred="true"} ! myeloid leukocyte is_a: CL:0002274 ! histamine secreting cell intersection_of: CL:0000766 ! myeloid leukocyte intersection_of: BFO:0000051 GO:0030141 ! has part secretory granule intersection_of: CL:4030046 PR:000001865 ! lacks_plasma_membrane_part interleukin-3 receptor class 2 alpha chain intersection_of: RO:0002104 PR:000001255 ! has plasma membrane part C-C chemokine receptor type 3 intersection_of: RO:0002104 PR:000006169 ! has plasma membrane part cell surface glycoprotein CD200 receptor 3 intersection_of: RO:0002215 GO:0002349 ! capable of histamine production involved in inflammatory response intersection_of: RO:0002215 GO:0002539 ! capable of prostaglandin production involved in inflammatory response intersection_of: RO:0002215 GO:0002660 ! capable of positive regulation of peripheral tolerance induction intersection_of: RO:0002215 GO:0002690 ! capable of positive regulation of leukocyte chemotaxis intersection_of: RO:0002215 GO:0002830 ! capable of positive regulation of type 2 immune response intersection_of: RO:0002215 GO:0030210 ! capable of heparin proteoglycan biosynthetic process intersection_of: RO:0015015 PR:000002065 ! has high plasma membrane amount mast/stem cell growth factor receptor intersection_of: RO:0015015 PR:000007431 ! has high plasma membrane amount high affinity immunoglobulin epsilon receptor subunit alpha relationship: BFO:0000051 GO:0030141 ! has part secretory granule relationship: CL:4030046 PR:000001865 ! lacks_plasma_membrane_part interleukin-3 receptor class 2 alpha chain relationship: RO:0002104 PR:000001255 ! has plasma membrane part C-C chemokine receptor type 3 relationship: RO:0002104 PR:000006169 ! has plasma membrane part cell surface glycoprotein CD200 receptor 3 relationship: RO:0002202 CL:0000831 ! develops from mast cell progenitor relationship: RO:0002215 GO:0002349 ! capable of histamine production involved in inflammatory response relationship: RO:0002215 GO:0002539 ! capable of prostaglandin production involved in inflammatory response relationship: RO:0002215 GO:0002660 ! capable of positive regulation of peripheral tolerance induction relationship: RO:0002215 GO:0002690 ! capable of positive regulation of leukocyte chemotaxis relationship: RO:0002215 GO:0002830 ! capable of positive regulation of type 2 immune response relationship: RO:0002215 GO:0030210 ! capable of heparin proteoglycan biosynthetic process relationship: RO:0015015 PR:000002065 ! has high plasma membrane amount mast/stem cell growth factor receptor relationship: RO:0015015 PR:000007431 ! has high plasma membrane amount high affinity immunoglobulin epsilon receptor subunit alpha property_value: RO:0002175 NCBITaxon:9606 property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0000097" xsd:string {name="mast cell on CELLxGENE CellGuide"} property_value: terms:description "Mast cells, also known as mastocytes, are a type of innate immune cell. They originate from multipotent hematopoietic progenitor cells within the bone marrow, after which they migrate into nearly all tissues throughout the body. In these tissues, mast cells undergo complete maturation, with the exception of the blood. They are most densely located in the interfaces between the internal and external environments, such as the skin, respiratory system, and gastrointestinal mucosa.\nMast cells are crucial players against pathogens and serve as first-line defense components. They contain numerous granules rich in histamine and heparin and are known primarily for their role in allergy and anaphylaxis. Upon encountering an allergen, pathogen, or even certain drugs and toxins, mast cells release these mediators via degranulation. Histamine induces vasodilation and vascular permeability, allowing for immune cells to rapidly reach the site of infection, while heparin prevents clotting in these areas to facilitate immune cell recruitment. Mast cells may also selectively secrete mediators without degranulation.\nThese cells also play other functions beyond immune defense. They are involved in wound healing processes and maintenance of tissue integrity, angiogenesis, and even regulation of physiological functions in the gut. Consequently, because of their wide-ranging impacts, abnormalities in mast cell function can result in various disorders, including those related to allergies, inflammation, and autoimmune conditions.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1007/s11894-010-0132-1", xref="DOI:10.1007/s12016-019-08729-w", xref="DOI:10.1016/j.bbadis.2010.12.014", xref="DOI:10.1056/NEJMra1409760", xref="DOI:10.1146/annurev-immunol-071719-094903"} [Term] id: CL:0000098 name: sensory epithelial cell def: "A specialized epithelial cell involved in sensory perception. Restricted to special sense organs of the olfactory, gustatory, and vestibulocochlear receptor systems; contain sensory cells surrounded by supportive, non-receptive cells." [GOC:tfm, ISBN:0517223651, ISBN:0721662544] comment: The term "neuroepithelial cell" is used to describe both this cell type and neurecto-epithelial cell (CL:0000710). subset: human_subset subset: mouse_subset synonym: "neuroepithelial cell" BROAD [] xref: BTO:0004301 xref: ZFA:0009050 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000066 ! epithelial cell is_a: CL:0000197 ! sensory receptor cell intersection_of: CL:0000066 ! epithelial cell intersection_of: RO:0002215 GO:0050906 ! capable of detection of stimulus involved in sensory perception property_value: skos:prefLabel "sensory epithelial cell" xsd:string [Term] id: CL:0000099 name: interneuron def: "Most generally any neuron which is not motor or sensory. Interneurons may also refer to neurons whose axons remain within a particular brain region as contrasted with projection neurons which have axons projecting to other brain regions." [GOC:tfm, MESH:D007395] subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "CNS interneuron" RELATED [] xref: BTO:0003811 xref: FBbt:00005125 {sssom:mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"} xref: FMA:67313 xref: WBbt:0005113 xref: ZFA:0009051 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:2000029 ! central nervous system neuron relationship: BFO:0000050 UBERON:0001017 ! part of central nervous system property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "interneuron" xsd:string [Term] id: CL:0000100 name: motor neuron def: "An efferent neuron that passes from the central nervous system or a ganglion toward or to a muscle and conducts an impulse that causes or inhibits movement." [MESH:D009046, PMID:16875686] subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "motoneuron" EXACT [] xref: BTO:0000312 xref: FBbt:00005123 {sssom:mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"} xref: FMA:83617 xref: WBbt:0005409 xref: ZFA:0009052 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000527 ! efferent neuron property_value: RO:0002175 NCBITaxon:9606 property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0000100" xsd:string {name="motor neuron on CELLxGENE CellGuide"} property_value: skos:prefLabel "motor neuron" xsd:string property_value: terms:description "Motor neurons, also known as motoneurons, are a type of neural cell that is fundamental to voluntary movement of muscles. Located within the central nervous system (CNS), motor neurons in the motor cortex travel to the brainstem and spinal cord. Motor neurons in the brainstem and spinal cord extend their lengthy axons out to muscles throughout the body. These specialized neurons are an inherent part of the so-called somatic division of the nervous system which mediates conscious control of skeletal muscles.\nThe primary function of motor neurons is to relay signals from the CNS to the body's many muscles, controlling both their contraction and relaxation. In response to impulses transmitted from the brain or spinal cord, it creates an electrical signal (action potential), which travels along its axon to cause the controlled movement of specific muscles. Motor neurons can connect with skeletal muscles, cardiac muscles, or glands, leading to three respective types: somatic motor neurons, autonomic motor neurons, and the neurons of the enteric nervous system.\nKey components of motor neurons include the cell body (soma), dendrites, and axons. The cell body houses the nucleus and is the site of the neuron's intrinsic functions. Dendrites are thin structures that branch from the cell body and receive messages (electrical signals) from other neurons. The axon, a long, single tail-like extension, carries these signals away from the cell body towards the targeted muscle. If a motor neuron is damaged or dies, the muscle or gland it controls can lose function, which can result in conditions like motor neuron disease, leading to muscle weakness and atrophy.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1016/j.semcdb.2017.11.016", xref="DOI:10.1146/annurev.neuro.051508.135722", xref="DOI:10.1249/JES.0000000000000032", xref="DOI:10.3389/fncel.2014.00293"} [Term] id: CL:0000101 name: sensory neuron def: "Any neuron having a sensory function; an afferent neuron conveying sensory impulses." [ISBN:0721662544] subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset xref: BTO:0001037 xref: FBbt:00005124 {sssom:mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"} xref: FMA:84649 xref: MESH:D011984 xref: WBbt:0005759 xref: ZFA:0009053 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000526 ! afferent neuron intersection_of: CL:0000540 ! neuron intersection_of: RO:0002215 GO:0050906 ! capable of detection of stimulus involved in sensory perception relationship: RO:0002215 GO:0050906 ! capable of detection of stimulus involved in sensory perception property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "sensory neuron" xsd:string [Term] id: CL:0000102 name: polymodal neuron def: "A neuron type that respond to multiple stimuli such as mechanical, thermal and chemical. This neuron type is responsible for integrating different types of sensory inputs, allowing organisms to respond appropriately to diverse environmental challenges." [PMID:23749412, PMID:36381588] subset: human_subset subset: mouse_subset synonym: "polymodal sensory neuron" RELATED [PMID:23749412] xref: ZFA:0009054 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:2000032 ! peripheral nervous system neuron [Term] id: CL:0000103 name: bipolar neuron def: "A type of interneuron that has two neurites, usually an axon and a dendrite, extending from opposite poles of an ovoid cell body." [GOC:tfm, ISBN:0444009442] subset: BDS_subset subset: cellxgene_subset subset: human_subset subset: mouse_subset xref: FMA:67282 xref: ZFA:0009055 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000099 ! interneuron intersection_of: CL:0000099 ! interneuron intersection_of: RO:0000053 PATO:0070006 ! has characteristic cortical bipolar morphology relationship: RO:0000053 PATO:0070006 ! has characteristic cortical bipolar morphology property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0000103" xsd:string {name="bipolar neuron on CELLxGENE CellGuide"} property_value: terms:description "The bipolar neuron is a type of nerve cell primarily found mainly in the sensory systems of the human body. These specialized cells possess two distinctive extensions or processes - one axon and one dendrite, emerging from the cell body on opposite ends, which gives them their bipolar appearance. These two extensions serve as conduits for electrical signals, with the dendrite primarily playing the role of receiving signals, and the axon transmitting them further.\nFunctionally, bipolar neurons are crucial in facilitating the transmission of special senses, particularly in the senses of sight, smell, hearing, and balance. For example, the bipolar neurons in the retina convey information about light intensity, color, and movement from the photoreceptors to the ganglion cells, forming part of the pathway for visual input to travel towards the brain. \nSimilarly, in the olfactory system, the olfactory cells are bipolar neurons characterized by a peripheral process, called the olfactory rod, which projects fine cilia. These cilia are the sites of olfactory receptors which play a critical role in recognizing thousands of odorant molecules and transmit information about smell from the nose to the brain. \nBipolar neurons are also involved in hearing. The vestibular ganglion contains thousands of bipolar neurons that receive sensory signals from hair cells in the inner ear. The nerve signals pass through the bipolar neurons and leave along the vestibular nerve. \nThe morphology of bipolar neurons with their single dendrite and axon also subtly boosts their efficiency, maintaining a streamlined path for signal conduction. Their distinctive structuring allows for faster and more targeted relay of sensory information from the body's peripheries to the central nervous system. Loss or damage of these neurons would directly impact sensory reception and could lead to disorders related to vision, hearing, smell, or balance, underlining the significance of this cell type in the body's sensory capacity.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1016/j.cell.2016.07.054", xref="DOI:10.1016/j.yexcr.2006.10.010", xref="DOI:10.1038/nrn3783", xref="DOI:10.1152/physrev.1986.66.3.772", xref="https://www.sciencedirect.com/topics/neuroscience/bipolar-neuron"} [Term] id: CL:0000104 name: multipolar neuron def: "A neuron with three or more neurites, usually an axon and multiple dendrites." [FMA:67287, GOC:tfm] subset: BDS_subset subset: human_subset subset: mouse_subset xref: FMA:67287 xref: ZFA:0009056 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:2000029 ! central nervous system neuron relationship: RO:0000053 PATO:0070026 ! has characteristic multipolar neuron morphology property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0000104" xsd:string {name="multipolar neuron on CELLxGENE CellGuide"} property_value: terms:description "A multipolar neuron is a specialized type of neuron that comprises one axon and multiple dendrites, distinguishing it from other varieties in the neuronal family. This cell type is distinctively known for its structural architecture and extraordinary capabilities in information processing. The multipolar configuration enables a wide branching network that supports the reception, integration, and transmission of signals over varying distances, translating into complex functionalities like thought, action, and perception.\nThe primary function of a multipolar neuron is to process and transmit information in the form of electrical impulses or action potentials. Each of the multiple dendrites acts as a receiver, collecting synaptic inputs from other neurons and transferring these signals to the neuron's cell body. Here, the information is assembled and, upon reaching a particular threshold, will trigger the generation of an action potential along the axon, the singular elongated projection that results in the neuron's output. This signal propagation, facilitated by the axon's myelination and nodes of Ranvier, leads to highly efficient and fast information transmission to other neurons, muscle cells, gland cells, and other organs.\nThe capacity of multipolar neurons to establish vast connections with other neurons makes them the primary constituents of the central nervous system. They play indispensable roles in both sensory and motor pathways, as well as in higher cognitive functions such as memory and learning. These neurons also enrich the autonomic system, contributing to both sympathetic and parasympathetic pathways. Hence, multipolar neurons play an essential role in performing and regulating a plethora of activities, ranging from basic reflexes to intricate cognitive processes.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1016/j.autneu.2006.05.003", xref="DOI:10.1101/cshperspect.a001644", xref="DOI:10.1126/science.3059497", xref="DOI:10.1523/JNEUROSCI.1610-15.2015"} [Term] id: CL:0000105 name: pseudounipolar neuron def: "Neuron with two neurites that are fused grossly when they protrude from the soma and bifurcate a short distance from the soma." [FMA:67305, GOC:tfm] subset: human_subset subset: mouse_subset xref: FMA:67305 xref: ZFA:0009057 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:2000032 ! peripheral nervous system neuron [Term] id: CL:0000106 name: unipolar neuron def: "Neuron with one neurite that extends from the cell body." [FMA:67278, GOC:nv] subset: BDS_subset subset: human_subset subset: mouse_subset xref: FMA:67278 xref: ZFA:0009058 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:2000032 ! peripheral nervous system neuron [Term] id: CL:0000107 name: autonomic neuron def: "A neuron whose cell body is within an autonomic ganglion." [GOC:tfm] subset: human_subset subset: mouse_subset xref: FMA:80121 xref: ZFA:0009059 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: BFO:0000002 is_a: CL:2000032 ! peripheral nervous system neuron intersection_of: CL:0000540 ! neuron intersection_of: RO:0002100 UBERON:0002410 ! has soma location autonomic nervous system relationship: RO:0002100 UBERON:0002410 ! has soma location autonomic nervous system [Term] id: CL:0000108 name: cholinergic neuron def: "A neuron that uses acetylcholine as a vesicular neurotransmitter." [GOC:tfm] subset: human_reference_atlas subset: human_subset subset: mouse_subset xref: BTO:0004902 xref: FBbt:00007173 {sssom:mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"} xref: FMA:84796 xref: MESH:D059329 xref: WBbt:0006840 xref: ZFA:0009060 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000151 ! secretory cell is_a: CL:0000540 ! neuron intersection_of: CL:0000540 ! neuron intersection_of: RO:0002215 GO:0014055 ! capable of acetylcholine secretion, neurotransmission relationship: RO:0002215 GO:0014055 ! capable of acetylcholine secretion, neurotransmission property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "cholinergic neuron" xsd:string [Term] id: CL:0000109 name: adrenergic neuron subset: human_subset subset: mouse_subset xref: MESH:D059331 xref: ZFA:0009061 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:4033050 ! catecholaminergic neuron [Term] id: CL:0000110 name: peptidergic neuron def: "A neuron that uses neuropeptides as transmitters." [doi:10.1016/B978-012589762-4/50021-9, PMID:23040809] subset: human_subset subset: mouse_subset xref: FBbt:00004101 {sssom:mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"} xref: ZFA:0009062 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000540 ! neuron relationship: RO:0002215 GO:0002790 ! capable of peptide secretion [Term] id: CL:0000112 name: columnar neuron def: "A neuron of the invertebrate central nervous system. This neuron innervates the central complex (CX) of an invertebrate brain and it forms columnar patterns with its dendrites. It is involved in navigation and spatial processing." [PMID:34696823, PMID:37608556] comment: Columnar neurons have been widely studied in Diptera, locusts, honey bees and other insects. In the mammalian brain, a "columnar organisation" is referred to neurons of the neocortex, however these differ from columnar neurons which are found in the insects central nervous system. {xref="PMID:37608556", xref="PMID:18837039", xref="PMID:32374034", xref="PMID:9153131", xref="PMID:34696823"} is_a: CL:0000028 ! CNS neuron (sensu Nematoda and Protostomia) is_a: CL:0008028 ! visual system neuron relationship: RO:0002215 GO:0007601 ! capable of visual perception [Term] id: CL:0000113 name: mononuclear phagocyte def: "A vertebrate phagocyte with a single nucleus." [GOC:add, GOC:tfm, ISBN:0781735149] subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset xref: BTO:0001433 xref: ZFA:0009064 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000518 {is_inferred="true"} ! phagocyte (sensu Vertebrata) is_a: CL:0000842 ! mononuclear leukocyte intersection_of: CL:0000518 ! phagocyte (sensu Vertebrata) intersection_of: RO:0000053 PATO:0001407 ! has characteristic mononucleate property_value: RO:0002175 NCBITaxon:9606 property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0000113" xsd:string {name="mononuclear phagocyte on CELLxGENE CellGuide"} property_value: terms:description "Mononuclear phagocytes are immune cells that form a critical part of the body's innate immune system, the body's first line of defense against infections. Mononuclear phagocytes are characterized by the presence of a single, large nucleus. The ‘Mononuclear Phagocyte System’ nomenclature was introduced to distinguish mononuclear monocytes and macrophages from other cells with multiple nuclei. However, the cells within the mononuclear phagocyte system represent a highly heterogeneous group, all of which are able to perform highly efficient phagocytosis - engulfing and digesting microbes and cellular debris to fight infections and to maintain normal tissue homeostasis. \nIn addition to phagocytosis, mononuclear phagocytes also secrete chemical compounds to recruit other immune cells to a site of infection. These cells produce different types of signaling molecules, including cytokines, chemokines, and reactive oxygen species, triggering a cascade of responses to ensure rapid and efficient containment and neutralization of invading pathogens. These cells are also involved in antigen presentation, a process essential for stimulating an adaptive immune response. They can process and present antigens to T cells, thereby linking the innate and adaptive immune responses.\nMononuclear phagocytes play key roles in tissue repair and remodeling. After infection or injury, these cells help in the clearance of dead cells and debris, a crucial step in the initiation of tissue remodeling and the resolution of inflammation. Overall, mononuclear phagocytes are versatile cells that have tailored their functions to meet the unique challenges of different tissues within the body. They are pivotal in homeostasis, immunity, and inflammation, making them important aspects in a range of human diseases including infection, autoimmunity, and cancer.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1016/j.coi.2005.11.008", xref="DOI:10.1038/nri3087", xref="DOI:10.3389/fimmu.2019.01893"} [Term] id: CL:0000114 name: surface ectodermal cell def: "An ectodermal cell that is part of the external ectoderm, forming the outermost layer of the developing embryo. It is characterized by its polarized nature, with distinct apical and basal surfaces (Ferrante Jr., Reinke, & Stanley, 1995). Surface ectodermal cell gives rise to the epidermis, hair follicles, nails, sensory organs, and specialized structures like the apical ectodermal ridge crucial for limb development (Skoufa et al., 2024)." [doi:/10.1101/2024.07.02.601324, PMID:7892198, Wikipedia:Surface_ectoderm] subset: human_subset subset: mouse_subset synonym: "cell of surface ectoderm" EXACT [] synonym: "surface ectoderm cell" EXACT [doi:/10.1101/2024.07.02.601324] xref: FMA:72552 is_a: CL:0000221 ! ectodermal cell intersection_of: CL:0000221 ! ectodermal cell intersection_of: BFO:0000050 UBERON:0000076 ! part of external ectoderm relationship: BFO:0000050 UBERON:0000076 ! part of external ectoderm property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0000114" xsd:string {name="surface ectodermal cell on CELLxGENE CellGuide"} property_value: terms:description "Surface ectoderm cells give rise to external structures such as the epidermis, hair, nails, and sweat glands. They are critical during the early stages of embryonic development, where they delineate and create the organism's exterior body plan. Beyond forming the organism's physical exterior, surface ectodermal cells have other significant roles. For instance, these cells lead to the development of the anterior pituitary gland and the enamel of the teeth. They are also integral to the formation of the sensory organs, including the eyes and the ears. In the eyes, they form the cornea and lens epithelium. In the ears, they form the external ear canal and certain parts of the inner ear. Therefore, these cells are instrumental in the development of various sensory systems in an organism.\nCertain abnormalities or mutations in surface ectodermal cells could lead to medical conditions known as ectodermal dysplasias. These are a group of inherited disorders affecting the development or function of teeth, hair, nails, and sweat glands. Therefore, understanding the formation and function of surface ectodermal cells is also important in identifying and addressing certain genetic disorders and conditions. In summary, surface ectodermal cells are essential in embryonic development, contributing to the creation of the external physical appearance and the sensory organs of an organism.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1038/srep32007", xref="https://www.ncbi.nlm.nih.gov/books/NBK539836/", xref="https://www.ncbi.nlm.nih.gov/books/NBK563130"} [Term] id: CL:0000115 name: endothelial cell def: "An endothelial cell comprises the outermost layer or lining of anatomical structures and can be squamous or cuboidal. In mammals, endothelial cell has vimentin filaments and is derived from the mesoderm." [GOC:tfm, http://en.wikipedia.org/wiki/Endothelial_cell, https://sourceforge.net/tracker/?func=detail&atid=440764&aid=3364936&group_id=36855, MESH:D042783, PMID:21275341] comment: From FMA: 9.07.2001: Endothelial cell has always been classified as a kind of epithelial cell, specifically a squamous cell but that is not true. First, endothelial cell can either be squamous or cuboidal (e.g. high-endothelial cell) and secondly, it has different embryological derivation (mesodermal) than a true epithelial cell (ectodermal and endodermal). The basis for present classification is the fact that it comprises the outermost layer or lining of anatomical structures (location-based) but a better structural basis for the differentia is the cytoskeleton of the cell. Endothelial cell has vimentin filaments while an epithelial cell has keratin filaments. [Onard]. subset: cellxgene_subset subset: general_cell_types_upper_slim subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "endotheliocyte" EXACT [] xref: BTO:0001176 xref: CALOHA:TS-0278 xref: FMA:66772 xref: ZFA:0009065 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: BFO:0000002 is_a: CL:0000255 ! eukaryotic cell relationship: RO:0002202 CL:0000222 ! develops from mesodermal cell property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "endothelial cell" xsd:string [Term] id: CL:0000116 name: pioneer neuron def: "Pioneer neurons establish a pathway in the developing central nervous system and then undergo programmed cell death once the adult axons, which follow them, have made connections with the target site. Thus, they are a transient cell type involved in axon guidance." [GOC:cvs, GOC:tfm] subset: human_subset subset: mouse_subset xref: FBbt:00005128 {sssom:mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"} xref: ZFA:0009066 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000540 ! neuron [Term] id: CL:0000117 name: CNS neuron (sensu Vertebrata) subset: human_subset subset: mouse_subset xref: ZFA:0009067 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:2000029 ! central nervous system neuron relationship: BFO:0000050 UBERON:0001017 ! part of central nervous system [Term] id: CL:0000118 name: basket cell def: "Basket cells are inhibitory GABAergic interneurons of the brain. In general, dendrites of basket cells are free branching and contain smooth spines. Axons are highly branched. The branched axonal arborizations give rise to basket-like structures that surround the soma of the target cell. Basket cells form axo-somatic synapses, meaning their synapses target somas of other cells." [WikipediaVersioned:Basket_cell&oldid=951703880] subset: BDS_subset subset: human_subset subset: mouse_subset xref: ZFA:0009068 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0011005 ! GABAergic interneuron intersection_of: CL:0000099 ! interneuron intersection_of: RO:0000053 PATO:0070002 ! has characteristic basket cell morphology intersection_of: RO:0002215 GO:0061534 ! capable of gamma-aminobutyric acid secretion, neurotransmission relationship: RO:0000053 PATO:0070002 ! has characteristic basket cell morphology property_value: skos:prefLabel "basket cell" xsd:string property_value: terms:contributor https://orcid.org/0000-0002-2825-0621 [Term] id: CL:0000119 name: cerebellar Golgi cell def: "Large intrinsic neuron located in the granule layer of the cerebellar cortex that extends its dendrites into the molecular layer where they receive contact from parallel fibers. The axon of the Golgi cell ramifies densely in the granule layer and enters into a complex arrangement with mossy fiber terminals and granule cell dendrites to form the cerebellar glomerulus. Llinas, Walton and Lang. In The Synaptic Organization of the Brain. 5th ed. 2004." [NIFSTD:sao1415726815] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "cerebellar Golgi neuron" EXACT [] synonym: "cerebellum Golgi cell" EXACT [] synonym: "Golgi cell" EXACT [] synonym: "Golgi neuron" EXACT [] xref: MESH:D000080906 xref: ZFA:0009069 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:4023057 ! cerebellar inhibitory GABAergic interneuron relationship: RO:0002100 UBERON:0002956 ! has soma location granular layer of cerebellar cortex relationship: RO:0002113 UBERON:0002956 ! has presynaptic terminal in granular layer of cerebellar cortex relationship: RO:0002360 UBERON:0002974 ! has dendrite location molecular layer of cerebellar cortex property_value: foaf:depiction Candelabrum:cell.png {dc:license="https://creativecommons.org/licenses/by-nc-nd/4.0/", xref="doi:10.3389/fnins.2020.00293"} property_value: foaf:depiction http://purl.obolibrary.org/obo/cl/images/CB_circuits_PMID3650468_f2.png {dc:license="https://creativecommons.org/licenses/by-nc-nd/4.0/", xref="doi:10.1016/j.cnp.2022.11.002"} property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0000119" xsd:string {name="cerebellar Golgi cell on CELLxGENE CellGuide"} property_value: skos:prefLabel "cerebellar Golgi cell" xsd:string property_value: terms:description "Cerebellar Golgi cells are a specific type of inhibitory interneuron found within the granular layer of the cerebellum, a major part of the vertebrate brain responsible for motor control, learning, and cognitive functions. Named after the Italian scientist Camillo Golgi, these cells play a unique and important role in modulating electrical signals in the complex cerebellar neural network.\nThe distinctive feature of the cerebellar Golgi cells is their dendritic arbor that extends throughout the molecular layer of the cerebellum, in line with the axons of the granule cells. The axons of Golgi cells primarily synapse with the dendrites of granule cells, generating a synaptic feedback loop that plays a vital role in regulating the intensity and timing of signal transmission. They also form synapses with mossy fiber terminals, which provide primary input to the cerebellar cortex.\nFunctionally, cerebellar Golgi cells serve as \"gatekeepers\" of the cerebellar cortex. They have a strong inhibitory influence on granule cells, modulating the information flow to the Purkinje cells, the main output neurons of the cerebellar cortex. Thus, Golgi cells play a critical role in controlling the input-output relationship within the cerebellum, shaping the timing and strength of signals originating from various sensory and motor areas of the cerebral cortex. This regulatory function is instrumental for the fine-tuning of motor coordination, timing and learning. Thus, alterations in Golgi cell functions can contribute to a range of neurological and neuropsychiatric disorders such as ataxias and cognitive deficits.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1016/S0896-6273(00)81126-5", xref="DOI:10.1016/j.neuron.2011.10.030", xref="DOI:10.1113/jphysiol.2010.189605", xref="DOI:10.1126/science.1215101", xref="DOI:10.3389/fncir.2013.00093"} [Term] id: CL:0000120 name: granule cell def: "A neuron of the vertebrate central nervous system that is small in size. This general class includes small neurons in the granular layer of the cerebellar cortex, cerebral cortex neurons that are not pyramidal cells and small neurons without axons found in the olfactory bulb." [https://medical-dictionary.thefreedictionary.com/granule+cell] subset: cellxgene_subset subset: human_subset subset: mouse_subset xref: BTO:0003393 xref: ZFA:0009070 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:2000029 ! central nervous system neuron property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0000120" xsd:string {name="granule cell on CELLxGENE CellGuide"} property_value: skos:prefLabel "granule cell" xsd:string property_value: terms:description "Granule cells are a class of small neurons found significantly in the cerebellum, olfactory bulb, and the dentate gyrus of the hippocampus in the human central nervous system. Their name derives from the presence of internal granular structures and they are one of the most abundant cell types in the entire brain, with estimates suggesting they likely comprise over half of all neurons. Due to their location, these cells play a vital role in the modulation of motor coordination, the olfactory system, and some aspects of memory and learning.\nStructurally, granule cells differ depending on their location. They have unmyelinated, very thin, T-shaped axons and a few short dendrites in the cerebellum. These dendrites receive information from a variety of sources, while their axons transmit the information to other parts of the brain. In granule cells of the cerebellum, the axons form parallel fibers that run into the molecular layer and synapse onto Purkinje cells, stellate, and basket cells, setting up a neuronal circuit critical for generating precise and fluid movements.\nFunctionally, granule cells receive excitatory input from mossy fibers, which deliver sensory and motor information to the cerebellum, and this interaction is fundamental for the timing and coordination of body movements. In the olfactory bulb, granule cells process and modify olfactory information before passing it to the cerebral cortex, thereby aiding smell perception. Meanwhile, in the hippocampus, these cells participate in the formation and sorting of memories, particularly episodic memories. Due to their number, location, and function, the granule cells have a significant influence on cognition and behavior.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1016/S0168-0102(97)00099-0", xref="DOI:10.1016/j.brainresrev.2007.03.005", xref="DOI:10.1016/j.neubiorev.2016.02.021", xref="DOI:10.12688/f1000research.15021.1", xref="DOI:10.3389/fncir.2020.611841"} [Term] id: CL:0000121 name: Purkinje cell def: "An inhibitory neuron and the sole output neuron of the cerebellar cortex, the Purkinje cell's soma is located between the granular and molecular layers of the cerebellum. It is one of the largest neural cells in the mammalian brain, ranging from 50 to 80 micrometres in diameter. Purkinje cells have planar, fan-shaped dendrites that branch extensively with little overlap. This cell type receives synaptic input from parallel fibres, which modulate high-frequency spike activity known as \"simple spikes,\" and climbing fibres, which modulate infrequent calcium spike activity known as \"complex spikes\". Purkinje cells are involved in motor coordination, particularly in correcting movements in progress." [MESH:D011689, PMID:12907269, PMID:14568361, PMID:31424738, PMID:33288911, PMID:38168772] comment: Neurodegenerative disorders affecting Purkinje cells disrupt motor functions. Some of the neurodegenerative disorders that causes loss and degeration of Purkinje cells are Spinocerebellar ataxias (SCAs) (Josef P Kapfhammer and Etsuko Shimobayashi 2023), Friedreich's ataxia (FRDA) (Kevin C Kemp et al., 2016), Fetal alcohol syndrome (Laurent Servais et al., 2016), Dandy-Walker malformation (Alexander Atamian et al., 2024). {xref="PMID:27215193", xref="PMID:17535929", xref="PMID:37426070", xref="https://doi.org/10.1016/j.stem.2023.11.013"} subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "cerebellar Purkinje cell" EXACT [https://doi.org/10.1016/j.proghi.2004.07.002] synonym: "PC" RELATED OMO:0003000 [PMID:38168772] synonym: "PN" RELATED OMO:0003000 [PMID:28821816] synonym: "Purkinje neuron" EXACT [PMID:28821816] xref: BTO:0001011 xref: CALOHA:TS-0845 xref: FMA:67969 xref: ZFA:0009071 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000617 ! GABAergic neuron is_a: CL:1001611 ! cerebellar neuron relationship: RO:0002100 UBERON:0002979 ! has soma location Purkinje cell layer of cerebellar cortex property_value: foaf:depiction Candelabrum:cell.jpg {dc:license="https://creativecommons.org/licenses/by-nc-nd/4.0/", xref="doi:10.3389/fnins.2020.00293"} property_value: foaf:depiction http://purl.obolibrary.org/obo/cl/images/CB_circuits_PMID3650468_f2.png {dc:license="https://creativecommons.org/licenses/by-nc-nd/4.0/", xref="doi:10.1016/j.cnp.2022.11.002"} property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0000121" xsd:string {name="Purkinje cell on CELLxGENE CellGuide"} property_value: skos:prefLabel "Purkinje cell" xsd:string property_value: terms:description "Purkinje cells, named after the Czech anatomist Jan Evangelista Purkyně who discovered them, are unique inhibitory neurons in the cerebellar cortex. They are a critical part of the vertebrate nervous system as they provide the only signal output from the cortex to the cerebellar nuclei. They are one of the few types of neurons that are large enough to be seen with the naked eye. The most distinct hallmark of Purkinje cells is their elaborate dendritic arbor, which forms a broad and intricately branching structure resembling a tree. These numerous branches each receive excitatory synaptic inputs from more than 100,000 parallel fibers; in addition, a single climbing fiber makes hundreds of synapses to the soma and proximal dendrites. A single long axon forms an inhibitory projection to the cerebellar nuclei.\nPurkinje cells play key roles in the coordination of fine, voluntary motor movements and balance. As the sole output of all motor coordination in the cerebellar cortex, they serve as a central relay in the cerebro-cerebellar loop. Each Purkinje cell receives two types of synaptic input: one from parallel fibers (which are axons of granule cells), and the other from climbing fibers (originating from the inferior olivary nucleus). The Purkinje cells process and integrate these diverse kinds of input signals to generate output that controls timing and coordination of movements.\nPurkinje neurons show considerable synaptic plasticity. Throughout life, these cells continue to undergo long-term potentiation and depression at parallel fiber synapses, which cause long-lasting increase or decrease, respectively, of synaptic transmission and have been proposed as mechanisms for motor learning. \nPurkinje cells are also known to be implicated in a variety of diseases. Their progressive loss is a prime feature in certain types of ataxia, a collective term used to describe conditions characterized by loss of muscular control and coordination. Furthermore, a significant reduction in the density of Purkinje cells has been reported in conditions such as autism and Huntington’s disease.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1007/s12311-018-0985-7", xref="DOI:10.1038/nrn3886", xref="DOI:10.7554/eLife.63668", xref="https://www.ncbi.nlm.nih.gov/books/NBK545154/", xref="https://www.sciencedirect.com/topics/agricultural-and-biological-sciences/purkinje-cell"} [Term] id: CL:0000122 name: stellate neuron def: "A neuron that has dendritic processes radiating from the cell body forming a star-like shape." [ISBN:9780123973481] subset: BDS_subset subset: cellxgene_subset subset: human_subset subset: mouse_subset xref: BTO:0002316 xref: ZFA:0009072 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:2000029 ! central nervous system neuron intersection_of: CL:0000540 ! neuron intersection_of: RO:0000053 PATO:0070010 ! has characteristic stellate morphology relationship: RO:0000053 PATO:0070010 ! has characteristic stellate morphology property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0000122" xsd:string {name="stellate neuron on CELLxGENE CellGuide"} property_value: skos:prefLabel "stellate neuron" xsd:string property_value: terms:description "Stellate neurons are a specialized type of interneurons found predominantly in the cerebral cortex and the cerebellum, two major components of the brain's central nervous system. These neurons are named for their distinct star-like shape, characterized by short dendrites that radiate from the cell body in multiple directions. They are a key component of the mammalian neural circuit due to their unique morphology and crucial functions in neural communication.\nStellate neurons play a pivotal role in the processing and transmission of information within the brain. In the cerebellum, these neurons are predominantly inhibitory and release the neurotransmitter gamma-aminobutyric acid (GABA), effectively regulating the excitability of other neurons within the network and thus fine-tuning the neuron-to-neuron communication. Their extensive dendritic network allows for connections with multiple neurons allowing for the integration of synaptic inputs from various sources in the brain. This widespread connectivity places stellate neurons at the heart of information processing in the central nervous system.\nIn addition to their important inhibitory role in regulating and processing information, the role of stellate neurons in the cerebellum differs slightly from their cortical counterparts. The cortical spiny stellate neurons are excitatory and release the neurotransmitter glutamate. They are involved in motor control and responsible for coordinating precise, voluntary movements and maintaining posture and balance. Any dysfunction in these cerebellar neurons can lead to movement disorders, highlighting their significance in our daily activities.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1002/cne.901460304", xref="DOI:10.1007/s11055-006-0093-x", xref="DOI:10.1038/nn1698", xref="DOI:10.1126/science.aai8178", xref="DOI:10.1523/JNEUROSCI.2929-06.2006"} [Term] id: CL:0000123 name: neuron associated cell (sensu Vertebrata) subset: cellxgene_subset subset: human_subset subset: mouse_subset is_a: CL:0000095 ! neuron associated cell relationship: RO:0002162 NCBITaxon:7742 ! in taxon Vertebrata [Term] id: CL:0000124 name: obsolete glial cell (sensu Nematoda and Protostomia) comment: This is a grouping class that is no longer needed or wanted. property_value: IAO:0000233 https://github.com/obophenotype/cell-ontology/issues/715 is_obsolete: true [Term] id: CL:0000125 name: glial cell def: "A non-neuronal cell of the nervous system. They not only provide physical support, but also respond to injury, regulate the ionic and chemical composition of the extracellular milieu. Guide neuronal migration during development, and exchange metabolites with neurons." [MESH:D009457] comment: Not all glial cells develop from glioblasts, with microglia developing from the mesoderm instead. See https://github.com/obophenotype/cell-ontology/issues/1571 subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "neuroglia" RELATED [] synonym: "neuroglial cell" EXACT [] xref: BTO:0002606 xref: CALOHA:TS-0415 xref: FBbt:00005144 {sssom:mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"} xref: FMA:54536 xref: ZFA:0009073 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000095 ! neuron associated cell property_value: RO:0002175 NCBITaxon:9606 property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0000125" xsd:string {name="glial cell on CELLxGENE CellGuide"} property_value: skos:prefLabel "glial cell" xsd:string property_value: terms:description "Glial cells, also known as neuroglia or simply glia, are non-neuronal cells in the central and peripheral nervous systems that provide support and protection for neurons. They constitute approximately half of the total cells in the human brain and more than half in other parts of the nervous system. Glial cells perform several key functions including, but not limited to, maintaining homeostasis, forming the myelin sheath around the neuron axons, and providing support and nutrition to neurons.\nThese different functions are performed by various glial cell types, including astrocytes, oligodendrocytes, microglia and other specialized types. Astrocytes, for example, are the most abundant glial cells and provide metabolic and nutrient support to neurons, help regulate the extracellular ion and neurotransmitter levels, and play a role in the formation and maintenance of the blood-brain barrier, contributing to the overall homeostasis and functioning of the nervous system. Additionally, astrocytes are involved in synaptic communication and participate in processes such as synaptogenesis and synaptic pruning.\nOligodendrocytes in the central nervous system function to insulate neurons by producing a fatty substance known as myelin. The myelin sheath enhances the speed and efficiency of nerve impulse conduction along the axons. \nMicroglia, the immune cells of the central nervous system, protect neurons from pathogens and clear away dead neurons through phagocytosis, a process also known as cellular eating. They also contribute to the regulation of inflammation in response to signals of tissue damage or infection in the central nervous system by releasing cytokines and other signaling molecules that modulate the immune response.\nDespite their overarching function in the support and protection of neurons, glial cells have also been shown to play significant roles in the pathophysiology of many psychiatric and neurodegenerative diseases, such as Alzheimer’s, Parkinson’s Disease and multiple sclerosis.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1002/glia.24343", xref="DOI:10.1038/nn1988", xref="DOI:10.1101/cshperspect.a020602", xref="DOI:10.1126/science.aat0473", xref="DOI:10.3389/fncel.2017.00024"} [Term] id: CL:0000126 name: macroglial cell def: "A neuroglial cell of ectodermal origin, i.e., the astrocytes and oligodendrocytes considered together." [GOC:tfm, ISBN:0721662544] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "macroglia" RELATED OMO:0003004 [doi:10.1152/physrev.2001.81.2.871] synonym: "macrogliocyte" EXACT [] xref: BTO:0000771 xref: CALOHA:TS-2027 xref: FMA:54538 xref: ZFA:0009074 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000125 ! glial cell relationship: RO:0002202 CL:0000339 ! develops from glioblast (sensu Vertebrata) [Term] id: CL:0000127 name: astrocyte def: "A class of large neuroglial (macroglial) cells in the central nervous system - the largest and most numerous neuroglial cells in the brain and spinal cord. Astrocytes (from 'star' cells) are irregularly shaped with many long processes, including those with 'end feet' which form the glial (limiting) membrane and directly and indirectly contribute to the blood-brain barrier. They regulate the extracellular ionic and chemical environment, and 'reactive astrocytes' (along with microglia) respond to injury." [GOC:dsd, GOC:tfm, http://en.wikipedia.org/wiki/Astrocyte, MESH:D001253, PMID:11746784, PMID:12162730, PMID:12898703, PMID:20942978] comment: Astrocytes are reportedly CD68-negative, CD121a-positive, CD184-positive, CD192-positive, CRF-positive, EGFR-positive, GFAP-positive, GLUT1-positive, MBP-negative, and NGFR-positive. subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "astrocytic glia" EXACT [] xref: BTO:0000099 xref: CALOHA:TS-0060 xref: FMA:54537 xref: ZFA:0009075 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000126 ! macroglial cell property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0000128 name: oligodendrocyte def: "A class of large neuroglial (macroglial) cells in the central nervous system. Form the insulating myelin sheath of axons in the central nervous system." [http://en.wikipedia.org/wiki/Oligodendrocyte, MESH:D009836] comment: Oligodendrocytes are reportedly MDP-positive and CD4-negative. subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "oligodendroglia" RELATED [] synonym: "OLs" EXACT [PMID:8734446] xref: BTO:0000962 xref: CALOHA:TS-0709 xref: FMA:54540 xref: ZFA:0009076 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000126 {is_inferred="true"} ! macroglial cell is_a: CL:4023154 ! myelinating glial cell relationship: BFO:0000050 UBERON:0001017 ! part of central nervous system relationship: RO:0002202 CL:0002453 ! develops from oligodendrocyte precursor cell property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0000129 name: microglial cell def: "A transcriptomically distinct central nervous system macrophage found in the parenchyma of the central nervous system. Marker include CD11b-positive, F4/80-positive, and CD68-positive." [GOC:add, GOC:dsd, GOC:tfm, http://en.wikipedia.org/wiki/Microglia, ISBN:0721601464, MESH:D017628, PMID:11517395, PMID:12430718, PMID:14561199, PMID:14612429, PMID:16177057, PMID:19461673, PMID:2089275] comment: Unlike macroglial cells, microglial cells arise from hematopoietic stem cells in the yolk sac during early embryogenesis that populate the central nervous system. They derive from embryonic mesoderm and are not from neuroectoderm where glioblast develops from. Markers: Mouse: CD11b+, F4/80+, CD68+. They represent ~12% of the cells in the CNS, but they are not uniformly distributed within the CNS. A normal adult mouse brain has approximately 3.5x10e6 microglia. Microglia are also reportedly CD3-negative, CD4-positive, CD8-negative, CD11b-positive, CD11c-high, CD14-negative, CD19-negative, CD45-low, CD56-negative, CD163-negative, CD200R-positive, CD281-positive, CD282-positive, CD283-positive, CD284-positive, CD285-positive, CD286-positive, CD287-positive, CD288-positive, CD289-positive, Gr1-negative, nestin-positive, and PU.1-positive. {xref="PMID:23616747"} subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "brain macrophage" BROAD [] synonym: "brain-resident macrophage" EXACT [] synonym: "hortega cells" EXACT [http://www.copewithcytokines.de/] synonym: "MF.microglia.CNS" RELATED [] synonym: "microglia" RELATED OMO:0003004 [doi:10.1038/s41598-020-66092-9] synonym: "microgliocyte" EXACT [http://www.copewithcytokines.de/] xref: BTO:0000078 xref: BTO:0000962 xref: FMA:54539 xref: ZFA:0009077 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000125 ! glial cell is_a: CL:0000878 ! central nervous system macrophage intersection_of: CL:0000125 ! glial cell intersection_of: BFO:0000050 UBERON:0001017 ! part of central nervous system intersection_of: RO:0002104 PR:000001012 ! has plasma membrane part integrin alpha-M intersection_of: RO:0002104 PR:000001813 ! has plasma membrane part adhesion G protein-coupled receptor E1 intersection_of: RO:0002104 PR:000002064 ! has plasma membrane part macrosialin intersection_of: RO:0002215 GO:0045087 ! capable of innate immune response relationship: RO:0002104 PR:000001012 ! has plasma membrane part integrin alpha-M relationship: RO:0002104 PR:000001813 ! has plasma membrane part adhesion G protein-coupled receptor E1 relationship: RO:0002104 PR:000002064 ! has plasma membrane part macrosialin relationship: RO:0002202 CL:0000222 ! develops from mesodermal cell relationship: RO:0002215 GO:0045087 ! capable of innate immune response property_value: RO:0002175 NCBITaxon:9606 property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0000129" xsd:string {name="microglial cell on CELLxGENE CellGuide"} property_value: terms:description "Microglial cells, sometimes referred to as microglia, are a type of glial cell that primarily exist within the central nervous system (CNS), notably in the brain and the spinal cord. Classified among the resident immune cells, microglial cells represent about 10% of all cells found within the CNS. These cells are derived from progenitor cells in the yolk sac, which differentiates them from other types of glial cells (such as astrocytes and oligodendrocytes) that are derived from neuroectodermal cell lineages. \nThe primary role of microglial cells is to act as the first and main active form of immune defense in the CNS. They express a vast repertoire of pattern recognition receptors, which allow them to sense and eliminate microbes invading the CNS parenchyma. They represent one of the macrophage populations of the CNS and are responsible for phagocytosis (engulfing and destroying cellular waste or pathogens) in the neural environment. \nMicroglial cells are particularly responsive to pathogens and injuries and change their morphology in reaction to inflammation or insult: In the normal state they are characterized by a ramified shape with small processes; in response to stimuli, some microglia mature and change to an amoeboid shape. \nBeyond their macrophagic activity, they also perform synaptic pruning during brain development, eliminate unnecessarily produced neurons, and facilitate tissue regeneration and repair. they play integral roles in regulating neural development and supporting cell survival and are important for maintaining tissue homeostasis. \nWhile their protective role generally benefits the brain, their over-activation can occasionally lead to neuro-inflammatory diseases, underlining the importance of balanced microglial cell functions. They have been extensively studied for their association with neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease, and multiple sclerosis.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1016/j.cell.2019.08.053", xref="DOI:10.1016/j.conb.2022.102674", xref="DOI:10.1016/j.tins.2021.11.001", xref="DOI:10.1038/nri3086", xref="DOI:10.3389/fnins.2021.742065"} [Term] id: CL:0000130 name: neuron associated cell (sensu Nematoda and Protostomia) is_a: CL:0000095 ! neuron associated cell relationship: RO:0002162 NCBITaxon:33317 ! in taxon Protostomia [Term] id: CL:0000131 name: gut endothelial cell def: "An endothelial cell that lines the blood and lymphatic vessels of the digestive tract. This cell forms the gut–vascular barrier (GVB) through tight junctions and crosstalk with pericytes and enteric glial cells, regulating the passage of nutrients and immune cells while restricting microbial translocation into the bloodstream." [PMID:26564856] subset: cellxgene_subset subset: human_subset subset: mouse_subset xref: ZFA:0009078 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000115 ! endothelial cell intersection_of: CL:0000115 ! endothelial cell intersection_of: BFO:0000050 UBERON:0001555 ! part of digestive tract relationship: BFO:0000050 UBERON:0001555 ! part of digestive tract relationship: RO:0002202 CL:0000223 ! develops from endodermal cell property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0000131" xsd:string {name="gut endothelial cell on CELLxGENE CellGuide"} property_value: terms:description "Gut endothelial cells are a crucial component of the endothelium, a thin layer of single cells that line the interior surface of blood vessels and lymphatic vessels, including those in the digestive system or \"gut\". These cells plays an integral role in various physiological and metabolic functions, actively participating in nutrient absorption, host defense, and vascular homeostasis in the gut.\nThe primary function of gut endothelial cells lies in their ability to control the passage of materials and the transit of white blood cells into and out of the bloodstream. They achieve this through the formation of a semi-permeable barrier, in which permeability is regulated by tight junctions; complex structures that bring the cells together, sealing the space between them. This ensures a controlled, selective passage of nutrients, ions, and water from the bloodstream into the gut and vice versa, helping maintain homeostasis and overall health.\nGut endothelial cells also play a significant role in angiogenesis and serve as a critical regulator of the gut immune responses playing a modulative role in gut immune homeostasis and inflammatory responses. In addition, they generate nitric oxide, a potent vasodilator, which helps in maintaining vascular tonus, preventing platelet and leukocyte adhesion, and decreasing smooth muscle proliferation. These multi-faceted roles make gut endothelial cells indispensable for the normal functioning of the gut and overall health.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1038/nri2171", xref="DOI:10.1111/bph.14527", xref="DOI:10.3390/ijms23073698", xref="DOI:10.3748/wjg.v17.i5.578", xref="DOI:full/10.15252/emmm.202114121"} [Term] id: CL:0000132 name: corneal endothelial cell def: "An hexagonal, flattened, mitochondria-rich endothelial cell that forms a monolayer on the posterior surface of the cornea (the corneal endothelium). Corneal endothelial cells are derived from the neural crest and are responsible for keeping the cornea transparent by maintaining the tissue in a semi-dry state through the action of their ionic pumps and tight junction barrier." [GOC:tfm, PMID:21976958, PMID:23284695, PMID:34741068, PMID:36769303] subset: cellxgene_subset subset: eye_upper_slim subset: human_reference_atlas subset: human_subset subset: mouse_subset xref: CALOHA:TS-0172 xref: FMA:70614 xref: ZFA:0009079 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000115 ! endothelial cell relationship: BFO:0000050 UBERON:0001985 ! part of corneal endothelium relationship: RO:0002202 CL:0000008 ! develops from migratory cranial neural crest cell property_value: RO:0002175 NCBITaxon:9606 property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0000132" xsd:string {name="corneal endothelial cell on CELLxGENE CellGuide"} property_value: terms:description "Corneal endothelial cells are specialized cells located on the innermost layer of the cornea, known as the endothelium. The cornea is the clear outer layer of the eye that helps to transmit and focus light into the retina. The endothelium is crucial in maintaining corneal clarity by actively pumping water out of the corneal stroma, the thick, collagen-containing middle layer of the cornea, to prevent swelling and ensure transparency.\nCorneal endothelial cells are characterized by their unique hexagonal shape forming a mosaic, and they are highly metabolically active. Their primary function is to maintain corneal dehydration and thereby clarity through maintaining a barrier and an active 'pump-leak' mechanism, which regulates fluid and solute transport. This transport sustains the deturgescence (state of being non-swollen) of the corneal stroma, since stromal swelling can cause corneal opacification, hindering light transmission. Importantly, human corneal endothelial cells have limited regenerative capacity, so damage to them, through disease, aging, or surgical trauma may result in vision loss.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1016/j.exer.2011.06.004", xref="DOI:10.1038/s41598-020-64311-x", xref="DOI:10.1097/j.jcrs.0000000000000650", xref="DOI:10.4103/ijo.IJO_646_17"} [Term] id: CL:0000133 name: neurectodermal cell def: "Ectoderm destined to be nervous tissue." [GOC:tfm, ISBN:068340007X] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "neurectoderm cell" EXACT [] xref: ZFA:0009080 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000221 ! ectodermal cell property_value: skos:prefLabel "neurectodermal cell" xsd:string [Term] id: CL:0000134 name: mesenchymal stem cell alt_id: CL:0002452 def: "A connective tissue cell that normally gives rise to other cells that are organized as three-dimensional masses. In humans, this cell type is CD73-positive, CD90-positive, CD105-positive, CD45-negative, CD34-negative, and MHCII-negative. They may further differentiate into osteoblasts, adipocytes, myocytes, neurons, or chondroblasts in vitro. Originally described as residing in the bone marrow, this cell type is now known to reside in many, if not all, adult organs." [FB:ma, GOC:dsd, http://en.wikipedia.org/wiki/Mesenchymal_stem_cell, http://www.copewithcytokines.de/cope.cgi?key=mesenchymal%20stem%20cells, PMCID:PMC2613570, PMID:10102814, PMID:16923606, PMID:17986482, PMID:19960544] comment: Many but not all mesenchymal cells derive from the mesoderm. MSCs are reportedly CD3-negative, CD4-negative, CD5-negative, CD8-negative, CD11a-negative, CD11b-negative, CD14-negative, CD19-negative, CD29-positive, CD31-negative, CD34-negative, CD38-negative, CD40-negative, CD44-positive, CD45-negative, CD49-positive, CD54-positive, CD66b-negative, CD79a-negative, CD80-negative, CD102-positive, CD106-positive, CD117-positive, CD121a-positive, CD121b-positive, CD123-positive, CD124-positive, CD133-negative, CD146-positive, CD166-positive, CD271-positive, B220-negative, Gr1-negative, MHCI-positive, MHCII-negative, SSEA4-negative, sca1-positive, Ter119-negative, and glycophorin A-negative. Cultured MSCs are capable of producing stem cell factor, IL7, IL8, IL11, TGF-beta, cofilin, galectin-1, laminin-receptor 1, cyclophilin A, and MMP-2. subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "BMSC" RELATED OMO:0003000 [] synonym: "bone marrow stromal cells" NARROW [] synonym: "CFU-F" RELATED OMO:0003000 [] synonym: "colony-forming unit-fibroblast" NARROW [] synonym: "marrow stromal cells" NARROW [PMID:11378515] synonym: "mesenchymal precursor cell" RELATED [] synonym: "mesenchymal progenitor cells" RELATED OMO:0003004 [MESH:D044982] synonym: "mesenchymal stem cell" RELATED [] synonym: "mesenchymal stromal cell" RELATED [] synonym: "mesenchymal stromal cells" RELATED OMO:0003004 [] synonym: "MSC" RELATED OMO:0003000 [PMID:11378515] synonym: "stem cells, mesenchymal" RELATED OMO:0003004 [MESH:D044982] xref: BTO:0002625 xref: BTO:0003298 xref: FMA:70546 xref: ZFA:0009081 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000048 ! multi fate stem cell is_a: CL:0002320 {is_inferred="true"} ! connective tissue cell property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0000134" xsd:string {name="mesenchymal stem cell on CELLxGENE CellGuide"} property_value: seeAlso "https://github.com/obophenotype/cell-ontology/issues/474" xsd:string property_value: skos:prefLabel "mesenchymal stem cell" xsd:string property_value: terms:description "Mesenchymal stem cells (MSCs) are multipotent stromal cells that can differentiate into a variety of cell types, including osteoblasts, chondrocytes, myocytes, and adipocytes. These cells originate mainly from the mesoderm of the embryo, which forms connective tissues, muscle, and the circulatory and urinary systems. However, in adults, MSCs are found in multiple tissues, including bone marrow, adipose tissue, the umbilical cord, and dental tissues. \nThe primary function of MSCs is to maintain and repair the tissues in which they are found. When damage occurs, the MSCs are able to migrate to the site of injury, where they aid in regenerating the damaged tissue by differentiating into the required cell type and by secreting growth factors that enhance tissue repair and reduce inflammation. Furthermore, MSCs can also act as immunomodulators, suppressing immune reactions and reducing inflammation, both locally and systemically.\nApart from their role in tissue maintenance and repair, MSCs are integral to the field of regenerative medicine and are being investigated for their therapeutic potential in various clinical settings. Owing to their multipotent nature, immunomodulatory activity, and the relative ease of isolation, these cells can be engineered and translated into therapies to treat a variety of diseases, including bone and cartilage defects, liver diseases, heart disorders, and autoimmune diseases, amongst others. They have also been used as vectors for anticancer agents and in cell and gene therapy applications.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1038/cdd.2013.158", xref="DOI:10.1038/nri2395", xref="DOI:10.1038/s41536-019-0083-6", xref="DOI:10.3727/096368910X"} [Term] id: CL:0000135 name: circulating fibrocyte def: "A bone marrow-derived cell that predominantly develops from myeloid lineage-restricted progenitor cells and circulates in peripheral blood, characterized by co-expression of hematopoietic markers CD45 and CD34 along with stromal markers including collagen type I in both humans and mice (Chesney et al., 1997; Blakaj and Bucala, 2012). This spindle-shaped cell exhibits a unique dual identity, functionally bridging immune and stromal compartments with characteristics of both monocytes and fibroblasts. Predominantly arising from circulating monocytes, it migrates to injury sites via chemokine receptors and participates in wound repair through extracellular matrix deposition, cytokine secretion, and antigen presentation via MHC class II. As mesenchymal progenitors, fibrocytes can differentiate into fibroblasts, myofibroblasts, and adipocytes, contributing to both physiological repair and pathological fibrosis (Blakaj and Bucala, 2012)." [doi:/10.1186/1755-1536-5-S1-S6, GOC:dsd, GOC:tfm, PMID:20303382, PMID:20305780, PMID:29286323, PMID:31473260, PMID:32084275, PMID:9177213] comment: Cultured human fibrocytes are MHCI-positive, MHCII-positive, CD1a-negative, CD3-negative, CD4-negative, CD8-negative, CD10-negative, CD11b-positive, CD13-positive, CD14-negative, CD16-negative, CD18-positive, CD19-negative, CD25-negative, CD29-positive, CD32-positive, CD33-negative, CD34-positive, CD38-negative, CD40-positive, CD44-negative, CD45RO-positive, CD49a-positive, CD49b-positive, CD49c-negative, CD49d-negative, CD49e-positive, CD49f-negative, CD56-negative, CD58-positive, CD61-positive, CD64-positive, CD70-negative, CD71-positive, CD80-positive, CD83-negative, CD86-positive, CD103-negative, CD105-positive, CD181-positive, CD182-negative, CD183-positive, CD184-positive, CD185-negative, CD186-negative, CD191-positive, CD192-negative, CD193-positive, CD194-positive, CD195-positive, CD196-negative, CD197-positive, CD199-positive, desmin-negative, F4/80-positive, Gr1-positive, LSP-1-positive, MHCI-positive, MHCII-positive, alpha-SMA-negative, TCRab-negative, TCRgd-negative, and vimentin-positive. Fibrocytes are also capable of secreting angiogenin, bFGF, CCL2, CCL3, CCL4, CCL8, CXCL1, type I collagen, type III collagen, CTGF, fibronectin, GM-CSF, IL-1a, IL-6, IL-8, IL-10, M-CSF, MMP-9, PDGF-A, TGF-alpha, TGF-beta1, TNF-alpha, and VEGF-A. subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "monocyte-derived fibrocyte" NARROW [PMID:30826294] xref: FMA:63879 is_a: CL:0000499 {is_inferred="true"} ! stromal cell is_a: CL:0011026 ! progenitor cell relationship: RO:0002202 CL:0000839 ! develops from myeloid lineage restricted progenitor cell relationship: RO:0002215 GO:0002495 ! capable of antigen processing and presentation of peptide antigen via MHC class II relationship: RO:0002215 GO:0042060 ! capable of wound healing relationship: RO:0002215 GO:0045766 ! capable of positive regulation of angiogenesis [Term] id: CL:0000136 name: adipocyte alt_id: CL:0000450 def: "A fat-storing cell found mostly in the abdominal cavity and subcutaneous tissue of mammals. Fat is usually stored in the form of triglycerides." [MESH:D017667] subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "adipose cell" EXACT [] synonym: "fat cell" EXACT [] xref: BTO:0000443 xref: CALOHA:TS-0012 xref: FMA:63880 xref: ZFA:0009082 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: BFO:0000002 is_a: CL:0000325 ! stuff accumulating cell is_a: CL:0002320 ! connective tissue cell relationship: RO:0002202 CL:0000134 ! develops from mesenchymal stem cell property_value: RO:0002175 NCBITaxon:9606 property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0000136" xsd:string {name="adipocyte on CELLxGENE CellGuide"} property_value: skos:prefLabel "adipocyte" xsd:string property_value: terms:description "A fat cell, also known as an adipocyte, is a specialized type of connective tissue cell responsible for the storage of fat in the body. These cells can be found throughout the body, but are most densely located in adipose tissue, such as the subcutaneous tissue beneath the skin and around organs, and act as the body’s energy storage units.\nThe primary function of fat cells is to store energy in the form of fat, also known as triglycerides, for use during periods of caloric deficit. When we consume more calories than we use for energy, our bodies convert the excess energy into fat and store it in adipose tissue. \nFat cells also play a role in regulating energy balance by secreting hormones, such as leptin and adiponectin, which help to regulate appetite and metabolism. Fat calls have also been implicated in the development of obesity-related diseases, such as insulin resistance and type 2 diabetes. \nFinally, fat cells have been found to play a role in the immune system by secreting cytokines, which can either promote or inhibit inflammation depending on the type of cytokine produced.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1007/s10753-021-01559-z", xref="DOI:10.1091/mbc.e15-10-0749", xref="DOI:10.1098/rstb.2006.1859"} [Term] id: CL:0000137 name: osteocyte def: "A mature osteoblast that has become embedded in the bone matrix. They occupy a small cavity, called lacuna, in the matrix and are connected to adjacent osteocytes via protoplasmic projections called canaliculi." [GOC:tfm, MESH:D010011] comment: VSAO relationship simplified OBO_REL:integral_part_of VSAO:0000118 subset: human_subset subset: mouse_subset synonym: "bone cell" BROAD [] xref: BTO:0002038 xref: CALOHA:TS-1167 xref: FMA:66779 xref: VSAO:0000124 xref: ZFA:0009083 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: BFO:0000002 is_a: CL:0001035 ! bone cell is_a: CL:0002320 ! connective tissue cell relationship: BFO:0000050 UBERON:0002481 ! part of bone tissue relationship: RO:0002202 CL:0001040 ! develops from non-terminally differentiated osteoblast [Term] id: CL:0000138 name: chondrocyte def: "A skeletogenic cell that secretes a specialized, avascular, GAG-rich matrix, is embedded in cartilage tissue matrix, retains the ability to divide, and develops from a chondroblast cell." [GO_REF:0000034, MESH:D019902, PMID:32491508] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "cartilage cell" EXACT [] xref: BTO:0000249 xref: CALOHA:TS-0138 xref: FMA:66782 xref: ZFA:0009084 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000153 ! glycosaminoglycan secreting cell is_a: CL:0000667 ! collagen secreting cell is_a: CL:0007001 ! skeletogenic cell relationship: RO:0001025 UBERON:0002418 ! located in cartilage tissue relationship: RO:0002202 CL:0000058 ! develops from chondroblast property_value: skos:prefLabel "chondrocyte" xsd:string [Term] id: CL:0000140 name: odontocyte def: "Skeletogenic cell that secretes dentine matrix, is derived from odontogenic papilla. Embedded in dentine tissue, and is the transformation of a non-terminally differentiated odontoblast cell." [GO_REF:0000034] subset: human_subset subset: mouse_subset xref: ZFA:0009086 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: BFO:0000002 is_a: CL:0002320 ! connective tissue cell relationship: RO:0002202 CL:0000060 ! develops from odontoblast relationship: RO:0002202 CL:0000134 ! develops from mesenchymal stem cell relationship: RO:0003000 UBERON:0001751 ! produces dentine [Term] id: CL:0000141 name: cementocyte def: "An osteocytelike cell with numerous processes, trapped in a lacuna in the cement of the tooth." [ISBN:0781733901] comment: CHECK: wikipedia says that cementocytes no longer produce cementum, but the phenoscape def is: Skeletogenic cell that produces cementum, is part of the odontogenic papilla, and is a transformation of a cementoblast cell (no change to existing def). subset: human_subset subset: mouse_subset xref: FMA:63003 xref: ZFA:0009087 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000137 ! osteocyte relationship: BFO:0000050 UBERON:0005176 ! part of tooth enamel organ relationship: RO:0002202 CL:0000061 ! develops from cementoblast [Term] id: CL:0000142 name: hyalocyte def: "A cell occurring in the peripheral part of the vitreous body of the eye that may be responsible for production of hyaluronic acid and collagen." [GOC:tfm, PMID:19073178] subset: human_subset subset: mouse_subset synonym: "vitreous cell" RELATED [] xref: BTO:0004271 xref: FMA:70620 is_a: CL:0000499 ! stromal cell [Term] id: CL:0000143 name: guidepost cell is_a: CL:0000130 ! neuron associated cell (sensu Nematoda and Protostomia) [Term] id: CL:0000144 name: obsolete cell by function def: "OBSOLETE: A classification of cells by their primary end goal or behavior." [FB:ma] comment: This term was made obsolete because there is no difference in meaning between it and 'cell', as any cell can be classified by its function or behavior. If you have used this term in annotation, please replace it with cell (CL:0000000), native cell (CL:0000003), or cell in vitro (CL:0001034) as appropriate. is_obsolete: true consider: CL:0000000 consider: CL:0000003 consider: CL:0001034 [Term] id: CL:0000145 name: professional antigen presenting cell def: "A cell capable of processing and presenting lipid and protein antigens to T cells in order to initiate an immune response." [GOC:add, ISBN:0781735149] comment: Note change of name; nearly all somatic cells can present antigens to T cells via MHC Class I complexes leading to effector responses, but professional antigen presenting cells constitutively express MHC Class II as well as costimulatory molecules, and thus can initiate immune responses via T cells. subset: blood_and_immune_upper_slim subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "APC" RELATED OMO:0003000 [] xref: ZFA:0009088 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000738 ! leukocyte intersection_of: CL:0000738 ! leukocyte intersection_of: RO:0002215 GO:0002504 ! capable of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II relationship: RO:0002215 GO:0002504 ! capable of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0000145" xsd:string {name="professional antigen presenting cell on CELLxGENE CellGuide"} property_value: terms:description "Professional antigen presenting cells, also known as APCs, are essential orchestrators of adaptive immunity. These cells possess the abilities to capture and process antigens and constitutively express MHC class II molecules to facilitate antigen presentation. These cells are able to deliver the three signals to activate naïve T cells, thereby initiating adaptive immunity. \nProfessional APCs include dendritic cells, macrophages, and B cells. Among these, dendritic cells are often considered the predominant APC as they have been demonstrated to activate naïve T cells. Macrophages and B cells also possess antigen-processing machinery and constitutively express MHC class II molecules. Dendritic cells and macrophages obtain antigens via phagocytosis of cells and cell debris, while B cells obtain antigens via the B cell receptor.\nAPCs are responsible for stimulating an appropriate immune response. Following antigen presentation (signal 1), they deliver costimulatory signals (signal 2) and secrete mediators such as cytokines (signal 3) that shape the subsequent immune response. APCs can also induce tolerogenic responses to self-antigens. APCs play important roles in diseases such as cancer and autoimmune diseases.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1016/B978-0-12-394447-4.30111-0", xref="DOI:10.1038/nri3754", xref="DOI:10.1159/000512729", xref="DOI:10.3389/fimmu.2022.954936"} [Term] id: CL:0000146 name: simple columnar epithelial cell subset: human_reference_atlas subset: human_subset subset: mouse_subset xref: ZFA:0009089 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000075 ! columnar/cuboidal epithelial cell property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0000147 name: pigment cell def: "A pigment cell is a cell that contains pigment granules." [GOC:tfm] subset: human_subset subset: mouse_subset synonym: "chromatocyte" EXACT [] synonym: "chromatophore" EXACT [] xref: VHOG:0001678 xref: ZFA:0009090 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000325 ! stuff accumulating cell property_value: skos:prefLabel "pigment cell" xsd:string [Term] id: CL:0000148 name: melanocyte alt_id: CL:0000572 def: "A pigment cell derived from the neural crest. Contains melanin-filled pigment granules, which gives a brown to black appearance." [SANBI:mhl] subset: cellxgene_subset subset: general_cell_types_upper_slim subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "melanophore" NARROW [] xref: BTO:0000847 xref: CALOHA:TS-0613 xref: FMA:70545 xref: MESH:D008544 xref: VHOG:0001679 xref: ZFA:0009091 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: BFO:0000002 is_a: CL:0000147 ! pigment cell is_a: CL:0000255 ! eukaryotic cell intersection_of: CL:0000147 ! pigment cell intersection_of: BFO:0000051 GO:0042470 ! has part melanosome intersection_of: RO:0002202 CL:0000541 ! develops from melanoblast relationship: BFO:0000051 GO:0042470 ! has part melanosome relationship: RO:0002202 CL:0000541 ! develops from melanoblast property_value: RO:0002175 NCBITaxon:9606 property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0000148" xsd:string {name="melanocyte on CELLxGENE CellGuide"} property_value: terms:description "Melanocytes are specialized cells prevalently found in the skin, but also present in the hair follicles, eyes, inner ear, bones, heart, and brain. Their primary function is the synthesis of melanin, a pigment responsible for coloration of skin, hair, and eyes. The presence and distribution of this pigment play a crucial role in the body's defense mechanism against harmful ultraviolet radiation.\nIn addition to melanin production, melanocytes also engage in a variety of other biological functions. They play a fundamental role in the immune response, owing to their ability to present antigens to T cells. Furthermore, they contribute to the maintenance of the skin's homeostasis by regulating processes such as extracellular matrix remodeling and cytokine production. A balance in melanocyte function is pivotal, as dysfunctions often result in dermatological disorders. For instance, the loss of melanocytes or reduction in their function may lead to hypopigmentation conditions such as vitiligo, whereas an abnormal increase could result in hyperpigmentation disorders or melanoma, a dangerous type of skin cancer.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1002/med.21754", xref="DOI:10.1038/nrc.2016.37", xref="DOI:10.1111/j.1751-1097.2007.00226.x", xref="DOI:10.3390/ijms21249769", xref="https://www.sciencedirect.com/topics/agricultural-and-biological-sciences/melanocyte"} [Term] id: CL:0000149 name: visual pigment cell subset: human_subset subset: mouse_subset synonym: "pigment cell" BROAD [] is_a: CL:0000147 ! pigment cell property_value: skos:prefLabel "visual pigment cell" xsd:string [Term] id: CL:0000150 name: glandular secretory epithelial cell def: "An epithelial cell, located in a gland, that is specialised for the synthesis and secretion of specific biomolecules, such as hormones, or mucous." [GOC:tfm, ORCID:0000-0002-7073-9172] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "glandular epithelial cell" EXACT [] xref: CALOHA:TS-2085 xref: FMA:86494 is_a: CL:1100001 ! secretory epithelial cell intersection_of: CL:0000066 ! epithelial cell intersection_of: CL:0000151 ! secretory cell intersection_of: BFO:0000050 UBERON:0002530 ! part of gland relationship: BFO:0000050 UBERON:0002530 ! part of gland property_value: skos:prefLabel "glandular secretory epithelial cell" xsd:string [Term] id: CL:0000151 name: secretory cell def: "A cell that specializes in controlled release of one or more substances." [GOC:tfm, ISBN:0721662544] subset: cellxgene_subset subset: human_subset subset: mouse_subset xref: BTO:0003659 xref: FMA:86916 is_a: CL:0000000 ! cell intersection_of: CL:0000000 ! cell intersection_of: RO:0002215 GO:0032940 ! capable of secretion by cell relationship: RO:0002215 GO:0032940 ! capable of secretion by cell property_value: skos:prefLabel "secretory cell" xsd:string [Term] id: CL:0000152 name: exocrine cell def: "A cell of an exocrine gland; i.e. a gland that discharges its secretion via a duct." [ISBN:0198547684] subset: cellxgene_subset subset: human_subset subset: mouse_subset xref: FMA:16014 xref: ZFA:0009092 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000151 ! secretory cell is_a: CL:0000255 ! eukaryotic cell intersection_of: CL:0000151 ! secretory cell intersection_of: BFO:0000050 UBERON:0002365 ! part of exocrine gland relationship: BFO:0000050 UBERON:0002365 ! part of exocrine gland [Term] id: CL:0000153 name: glycosaminoglycan secreting cell def: "A cell that secretes glycosaminoglycans." [GOC:tfm] subset: human_subset subset: mouse_subset synonym: "GAG secreting cell" EXACT [] synonym: "hyaluronic acid secreting cell" NARROW [] xref: ZFA:0009093 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000327 ! extracellular matrix secreting cell is_a: CL:0000447 ! carbohydrate secreting cell property_value: skos:prefLabel "glycosaminoglycan secreting cell" xsd:string [Term] id: CL:0000154 name: protein secreting cell def: "Any secretory cell that is capable of some protein secretion." [FBC:Autogenerated] subset: human_subset subset: mouse_subset is_a: CL:0000151 ! secretory cell intersection_of: CL:0000151 ! secretory cell intersection_of: RO:0002215 GO:0009306 ! capable of protein secretion relationship: RO:0002215 GO:0009306 ! capable of protein secretion property_value: skos:prefLabel "protein secreting cell" xsd:string [Term] id: CL:0000155 name: peptic cell def: "An epithelial cell of the stomach that is part of the fundic gastric gland. This cell is characterized by a basally located nucleus, abundant rough endoplasmic reticulum, and large apical secretory granules. It produces and secretes pepsinogen, the inactive precursor of the digestive enzyme pepsin." [GOC:tfm, PMID:21907708, PMID:30571046, Wikipedia:Gastric_chief_cell] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "chief cell of stomach" EXACT [] synonym: "gastric chief cell" EXACT [Wikipedia:Chief_cell] synonym: "pepsinogen secreting cell" EXACT [] synonym: "zymogenic cell" EXACT [Wikipedia:Chief_cell] xref: FMA:62902 is_a: CL:0000152 ! exocrine cell is_a: CL:0000154 ! protein secreting cell is_a: CL:0002659 ! glandular epithelial cell of stomach relationship: BFO:0000050 UBERON:0010038 ! part of fundic gastric gland [Term] id: CL:0000156 name: obsolete antibody secreting cell def: "OBSOLETE: A cell of the lymphoid series that can react with antigen to produce specific cell products called antibodies. Various cell subpopulations, often B cells, can be defined, based on the different classes of immunoglobulins that they synthesize." [] comment: Consider using 'B cell ; CL:0000236' or one of its children instead. is_obsolete: true [Term] id: CL:0000157 name: surfactant secreting cell def: "A cell that specializes in secretion of surfactant in the alveoli of the lung." [GOC:tfm, ISBN:0721662544] subset: human_subset subset: mouse_subset is_a: CL:0000151 {is_inferred="true"} ! secretory cell intersection_of: CL:0000151 ! secretory cell intersection_of: RO:0002215 GO:0043129 ! capable of surfactant homeostasis relationship: RO:0002215 GO:0043129 ! capable of surfactant homeostasis [Term] id: CL:0000158 name: club cell def: "A non-mucous, epithelial secretory cell that is part of the tracheobronchial tree. A club cell has short microvilli but no cilia. A club cell is able to multiply and differentiate into ciliated cells to regenerate the bronchiolar epithelium and it also protects the tracheobronchial epithelium." [DOI:10.1183/09031936.00146609, DOI:10.1378/chest.12-2762, GOC:tfm, PMID:28128362, PMID:29874100, PMID:7905712] subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "Clara cell" EXACT [] xref: BTO:0004811 xref: FMA:14119 is_a: CL:0000157 ! surfactant secreting cell is_a: CL:0002202 ! epithelial cell of tracheobronchial tree is_a: CL:0008055 ! respiratory tract secretory epithelial cell is_a: CL:0011026 ! progenitor cell relationship: RO:0002104 GO:0005902 ! has plasma membrane part microvillus property_value: RO:0002175 NCBITaxon:9606 property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0000158" xsd:string {name="club cell on CELLxGENE CellGuide"} property_value: terms:description "Club cells, originally termed Clara cells, are specialized nonciliated epithelial cells primarily located in the bronchioles, or small airways, of the lungs. Compared to other cells in the lung epithelium, they are distinguished by their characteristic dome shape often marked by short, microvilli-like projections (but no cilia). Underneath their dome-like apex, they possess a large amount of cytoplasm containing numerous granules, and they have a round, centrally located nucleus. Their name 'club' was adopted to signify their appearance, which resembles a club or goblet.\nClub cells perform various crucial roles in maintaining the homeostasis of the respiratory tract. Among their functions is the production and secretion of a variety of proteins, including the club cell secretory protein (CCSP), which plays a role in the immune response of the lungs, particularly, in mitigating inflammation. The secretion of surfactant proteins by these cells also contributes to reducing surface tension in the alveoli, thus facilitating the process of gas exchange. Besides helping to defend against oxidative stress and inflammatory response, surfactants also aid in preventing the air sacs in the lungs from collapsing.\nAnother vital role of club cells is their capacity to self-proliferate and differentiate into ciliated cells or basal cells, highlighting their regenerative capacity. This quality is especially critical for maintaining the integrity of the epithelial layer in the lung following any injury or inflammation, aiding the lung tissue to recover and restore its function. Furthermore, it is speculated that club cells might minimize the adverse impact of harmful substances in the air we inhale, thanks to a range of cytochrome P450 enzymes present in them. These enzymes assist in detoxifying harmful substances, a protective mechanism that helps preserve the overall health of the lungs.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1038/s41385-020-00370-7", xref="DOI:10.1038/s41467-022-32052-2", xref="DOI:10.1152/ajplung.00192.2022", xref="DOI:10.1378/chest.14-3171", xref="DOI:10.2147/JIR.S284800"} [Term] id: CL:0000159 name: seromucus secreting cell subset: cellxgene_subset subset: human_subset subset: mouse_subset is_a: CL:0000151 ! secretory cell [Term] id: CL:0000160 name: goblet cell def: "A specialized, columnar, mucus secreting epithelial cell shaped like a flask or goblet. A narrow basal end contains the nucleus while the apical end is swollen by the accumulation of mucus laden secretory granules. Short microvilli project from the apical plasma membrane." [http://en.wikipedia.org/wiki/Goblet_cell, MESH:D020397] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "chalice cell" EXACT [] xref: BTO:0001540 xref: FMA:13148 xref: http://en.wikipedia.org/wiki/Goblet_cell xref: ZFA:0009094 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000319 ! mucus secreting cell is_a: CL:1100001 ! secretory epithelial cell relationship: BFO:0000051 GO:0005902 ! has part microvillus relationship: BFO:0000051 GO:0098594 ! has part mucin granule property_value: foaf:depiction "https://upload.wikimedia.org/wikipedia/commons/thumb/c/c4/404_Goblet_Cell_new.jpg/800px-404_Goblet_Cell_new.jpg" xsd:string {xref="http://cnx.org/content/col11496/1.6/", xref="https://commons.wikimedia.org/w/index.php?curid=30131227"} property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0000160" xsd:string {name="goblet cell on CELLxGENE CellGuide"} property_value: terms:description "Goblet cells are specialized, simple columnar, secretory epithelial cells that are mostly found in the respiratory and intestinal tracts. The term \"goblet\" refers to their shape, which resembles a flask or goblet, specially at their apical end which is swollen due to the accumulation of secretory granules. \nThe primary function of goblet cells is to to protect and lubricate the underlying tissues by secreting large quantities of mucin, a complex glycoprotein, which forms mucus when hydrated. In the respiratory tract, the mucus secreted by these cells traps dust, bacteria, viruses, and other potentially harmful particles in the inhaled air, preventing them from reaching the delicate tissues of the lungs. In the intestines, the goblet cells secrete mucus that acts as a protective barrier shielding the intestinal epithelium from dietary antigens, pathogens and prevents the intestinal epithelium from being eroded by the actions of the digestive enzymes and the abrasive action of passing food material.\nGoblet cells are capable of rapidly altering their secretory output in response to stimuli. For example, irritants like smoke or dust can trigger an increased rate of mucus production, as the body attempts to flush out the harmful particles. Conversely, in conditions such as chronic bronchitis and cystic fibrosis, overactive goblet cells can create a thick accumulation of mucus that obstructs the airways and fosters bacterial growth. Lastly, goblet cells are not static, rather, they undergo a dynamic process known as goblet cell metaplasia-differentiation, wherein non-goblet cells in response to chronic injury or inflammation, can differentiate into goblet cells leading to an accumulation of these cells in the tissue, known as goblet cell hyperplasia.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1016/S1357-2725(02)00083-3", xref="DOI:10.1038/s41575-022-00675-x", xref="DOI:10.1165/ajrcmb.25.5.f218", xref="DOI:10.1242/bio.20121701", xref="https://www.ncbi.nlm.nih.gov/books/NBK553208/"} [Term] id: CL:0000161 name: obsolete acid secreting cell property_value: IAO:0000233 https://github.com/obophenotype/cell-ontology/issues/427 is_obsolete: true consider: CL:0000162 [Term] id: CL:0000162 name: parietal cell def: "An epithelial cell of the stomach that is part of the fundic gastric gland. This cell is characterized by its pyramidal shape, abundant mitochondria, and a complex network of secretory canaliculi lined with microvilli. It secretes hydrochloric acid into the stomach lumen and produces intrinsic factor, essential for vitamin B12 absorption." [GOC:tfm, ISBN:0517223651, PMID:31613538, PMID:31670611] comment: Parietal cells have dynamic, actin-supported microvilli that increase in number during active secretion, playing a crucial role in secreting hydrochloric acid and intrinsic factor. The structure and regulation of these microvilli are influenced by proteins such as ASAP3, which modulates Arf6 activity and actin assembly, thereby controlling microvilli formation and parietal cell function. {xref="PMID:31613538", xref="PMID:29263912"} subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "gastric parietal cell" EXACT [PMID:29263912] synonym: "oxyntic cell" EXACT [Wikipedia:Parietal_cell] xref: BTO:0001780 xref: FMA:62901 is_a: CL:0000152 ! exocrine cell is_a: CL:0002659 ! glandular epithelial cell of stomach relationship: BFO:0000050 UBERON:0010038 ! part of fundic gastric gland relationship: BFO:0000051 GO:0005902 ! has part microvillus relationship: RO:0002215 GO:0001696 ! capable of gastric acid secretion [Term] id: CL:0000163 name: endocrine cell def: "A cell of an endocrine gland, ductless glands that secrete substances which are released directly into the circulation and which influence metabolism and other body functions." [MESH:D055098] subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "endocrinocyte" EXACT [] xref: FMA:83809 xref: ZFA:0009096 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000151 ! secretory cell is_a: CL:0000255 ! eukaryotic cell relationship: BFO:0000050 UBERON:0000949 ! part of endocrine system property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "endocrine cell" xsd:string [Term] id: CL:0000164 name: enteroendocrine cell def: "An endocrine cell that is located in the epithelium of the gastrointestinal tract or in the pancreas." [GOC:tfm, SANBI:mhl] subset: cellxgene_subset subset: human_subset subset: mouse_subset xref: BTO:0003865 xref: FMA:62930 xref: MESH:D019858 xref: ZFA:0009097 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000163 ! endocrine cell is_a: CL:1100001 ! secretory epithelial cell property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0000164" xsd:string {name="enteroendocrine cell on CELLxGENE CellGuide"} property_value: terms:description "Enteroendocrine cells are a specialized subset of cells located within the epithelial lining of both the small and large intestines, as well as the stomach and pancreas. Constituting less than 1% of the total population of intestinal cells, they are differentiated from a common intestinal cell progenitor, thus sharing lineage with absorptive and goblet cells of the intestines.\nThe distinct characteristic feature of an enteroendocrine cell is its inherent capacity to synthesize and secrete a plethora of gut hormones such as serotonin, somatostatin, neurotensin, cholecystokinin, secretin, gastric inhibitory peptide, motilin, and glucagon-like peptide-1. Integrated within this complex network of signaling agents, these substances control various aspects of the digestive system. Each enteroendocrine cell has its unique combination of hormones to release, determined by its position along the intestinal tract. Intriguingly, these hormones not only modulate local gut function, including motility, absorption and secretion, but also potentiate distant actions on other systems such as endocrine, nervous and immune and play a role in the feeling of satiety.\nThe release of these hormones from enteroendocrine cells is a highly regulated and dynamic process. The cells are equipped with sensory receptors localized on its luminal side that respond to various stimuli, including changes in nutrient composition, chemical or mechanical changes in the gut lumen, or even signals arising from commensal microbiota. This sensory input stimulates a signaling cascade within the cell, culminating in the release of specific hormones into the interstitial fluid. These hormones then make their way into the bloodstream, acting on their respective target receptors to mediate their duties. The multifunctional characteristics of enteroendocrine cells make them crucial for maintaining gut homeostasis and the overall physiological well being of the body.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1038/s41574-019-0168-8", xref="DOI:10.1111/j.1463-1326.2011.01438.x", xref="DOI:10.1196/annals.1294.001", xref="DOI:10.1210/endrev/bnaa018", xref="DOI:10.7554/elife.78512"} [Term] id: CL:0000165 name: neuroendocrine cell def: "A neuron that is capable of some hormone secretion in response to neuronal signals." [MESH:D055099] comment: The neurosecretory cell is neither an ordinary neuron nor an endocrine cell, but a combination of both. Its neuronal features resemble those of ordinary neurons concerning both structure and function. The production of a visible secretory material marks the neurosecretory neuron as a gland cell, and the fact that extractable cellular products act in the manner of hormones places it in the realm of endocrine elements. \n\nThe modern definition of neurosecretion has evolved to include the release of any neuronal secretory product from a neuron. {xref="https://www.clinicalkey.com/#!/content/book/3-s2.0-B9780323555968000073", xref="PMID:5342440"} subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "neurosecretory cell" RELATED [] synonym: "neurosecretory neuron" RELATED [] xref: BTO:0002691 xref: FBbt:00005130 {sssom:mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"} xref: FMA:83810 xref: ZFA:0009098 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000163 ! endocrine cell is_a: CL:0000527 ! efferent neuron is_a: CL:0000710 ! neurecto-epithelial cell is_a: CL:1100001 ! secretory epithelial cell intersection_of: CL:0000540 ! neuron intersection_of: RO:0002215 GO:0046879 ! capable of hormone secretion property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "neuroendocrine cell" xsd:string [Term] id: CL:0000166 name: chromaffin cell def: "A cell that stores epinephrine secretory vesicles. During times of stress, the nervous system signals the vesicles to secrete their hormonal content. Their name derives from their ability to stain a brownish color with chromic salts. Characteristically, they are located in the adrenal medulla and paraganglia of the sympathetic nervous system." [MESH:D019439] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "phaeochromocyte" EXACT [] xref: BTO:0000259 xref: FMA:69263 xref: ZFA:0009099 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000029 ! neural crest derived neuron is_a: CL:0000568 ! amine precursor uptake and decarboxylation cell property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0000166" xsd:string {name="chromaffin cell on CELLxGENE CellGuide"} property_value: skos:prefLabel "chromaffin cell" xsd:string property_value: terms:description "Chromaffin cells, also known as pheochromocytes, are neuroendocrine cells that are typically located in the adrenal medulla, the innermost part of the adrenal gland, which is situated on top of each kidney. Chromaffin cells are also found in small clusters, known as paraganglia, in various locations throughout the body, including the sympathetic nervous system. They derive their name from their ability to stain a brownish-black color upon exposure to chromic salts, a feature made possible due to their high content of granules rich in catecholamines and catecholamine-related neurotransmitters.\nThe primary function of chromaffin cells is the synthesis and release of catecholamines, specifically epinephrine (adrenaline) and norepinephrine (noradrenaline). These neurotransmitters are vital stress hormones that, when released by the adrenal chromaffing cells into the bloodstream, prepare the body for the 'fight or flight' response. This response can enhance the body's performance in a dangerous situation by increasing heart rate, elevating blood sugar, and increasing blood flow to the muscles. The chromaffin cells in paraganglia are responsible for the local release of catecholamines and play a role in regulating blood pressure and other autonomic functions.\nIn addition to their role in stress response, chromaffin cells also contribute to the body's immune response. They secrete several peptides including antimicrobial peptides, and the discovery of LPS and cytokine receptors on chromaffin cells suggests that the adrenal medulla may participate in some aspects of the immune response.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1002/cphy.c190003", xref="DOI:10.1016/j.biocel.2016.02.003", xref="DOI:10.3389/fendo.2018.00711", xref="DOI:10.3389/fimmu.2022.977175", xref="DOI:10.3389/fimmu.2022.977175/full"} [Term] id: CL:0000167 name: peptide hormone secreting cell def: "Any secretory cell that is capable of some peptide hormone secretion." [FBC:Autogenerated] subset: human_subset subset: mouse_subset xref: ZFA:0009100 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000151 ! secretory cell intersection_of: CL:0000151 ! secretory cell intersection_of: RO:0002215 GO:0030072 ! capable of peptide hormone secretion relationship: RO:0002215 GO:0030072 ! capable of peptide hormone secretion property_value: skos:prefLabel "peptide hormone secreting cell" xsd:string [Term] id: CL:0000168 name: insulin secreting cell def: "Any secretory cell that is capable of some insulin secretion." [FBC:Autogenerated] subset: human_subset subset: mouse_subset xref: BTO:0000783 xref: ZFA:0009101 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000154 ! protein secreting cell is_a: CL:0000167 ! peptide hormone secreting cell is_a: CL:0000255 ! eukaryotic cell intersection_of: CL:0000151 ! secretory cell intersection_of: RO:0002215 GO:0030073 ! capable of insulin secretion relationship: RO:0002215 GO:0030073 ! capable of insulin secretion [Term] id: CL:0000169 name: type B pancreatic cell def: "A cell that secretes insulin and is located towards the center of the islets of Langerhans." [GOC:tfm, http://en.wikipedia.org/wiki/Pancreatic_b_cell, ISBN:0517223651] comment: Pancreatic beta cells are also reportedly CD284-positive. Upon activation, they upregulate their CD14 expression. subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "B-cell of pancreatic islet" EXACT [FMA:70586] synonym: "beta cell" BROAD [ZFA:0009102] synonym: "beta cell islet" RELATED [MA:0002419] synonym: "beta cell of pancreatic islet" EXACT [FMA:70586] synonym: "insulin-secreting cell" EXACT [FMA:70586] synonym: "pancreatic B cell" EXACT [] synonym: "pancreatic B-cell" EXACT [FMA:70586] synonym: "pancreatic beta cell" EXACT [FMA:70586] synonym: "pancreatic islet core" EXACT [MA:0002419] synonym: "type B enteroendocrine cell" EXACT [FMA:70586] xref: BTO:0000783 xref: EV:0200009 xref: FMA:70586 xref: MA:0002419 xref: ncithesaurus:Beta_Cell xref: ZFA:0009102 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000168 {is_inferred="true"} ! insulin secreting cell is_a: CL:0008024 ! pancreatic endocrine cell intersection_of: CL:0000164 ! enteroendocrine cell intersection_of: BFO:0000050 UBERON:0000006 ! part of islet of Langerhans intersection_of: RO:0002215 GO:0030073 ! capable of insulin secretion relationship: BFO:0000050 UBERON:0000006 ! part of islet of Langerhans relationship: RO:0002202 CL:0002351 ! develops from progenitor cell of endocrine pancreas property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/2d-ftu/pancreas-islets-langerhans/v1.2/assets/2d-ftu-pancreas-islets-langerhans.png" xsd:string {terms:licence="http://creativecommons.org/licenses/by/4.0/", xref="doi:10.48539/HBM637.SFSW.654"} property_value: RO:0002175 NCBITaxon:9606 property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0000169" xsd:string {name="type B pancreatic cell on CELLxGENE CellGuide"} property_value: terms:description "Type B pancreatic cells, also known as beta cells, are one of the endocrine cell types located in the pancreas. They represent 70-80% of the cells in the islets of Langerhans, the endocrine part of this organ. Unique to mammals, Type B pancreatic cells are the predominant cell type in the pancreatic islets (50–80% of all islet endocrine cells) and play a crucial role in the body's metabolic regulation and glucose homeostasis. \nThe primary function of type B pancreatic cells is the production, storage, and release of insulin, accounting for almost all insulin production in the human body: each cell contains about 20 pg insulin. Insulin has a critical function in regulating blood sugar levels: whenever glucose levels in the blood are high, such as after a meal, type B pancreatic cells secrete insulin to promote glucose uptake into cells, transforming it into usable energy or storing it for later use. Additionally, insulin also inhibits glucose production by the liver, therefore lowering blood glucose levels.\nImpaired function of the type B cells is associated with type 1 and type 2 diabetes, metabolic diseases characterized by chronic hyperglycemia. In type 1 diabetes, an autoimmune response leads to the attack of the body’s own type B cells, resulting in the insufficient production and secretion of insulin. In type 2 diabetes, insulin resistance occurs, and type B cells are unable to compensate by producing more insulin.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1007/s40828-021-00140-3", xref="DOI:10.1038/s41574-020-00443-4", xref="DOI:10.1155/2017/1478294", xref="DOI:10.3389/fcell.2017.00055", xref="DOI:10.3390/ijms22126403"} [Term] id: CL:0000170 name: glucagon secreting cell def: "A cell that secretes glucagon." [GOC:tfm] subset: human_subset subset: mouse_subset synonym: "glucagon-secreting cell" EXACT [] xref: FMA:84045 xref: ZFA:0009103 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000167 ! peptide hormone secreting cell intersection_of: CL:0000151 ! secretory cell intersection_of: RO:0002215 GO:0070091 ! capable of glucagon secretion relationship: RO:0002215 GO:0070091 ! capable of glucagon secretion [Term] id: CL:0000171 name: pancreatic A cell def: "A type A enteroendocrine cell found in the periphery of the islets of Langerhans that secretes glucagon." [GOC:tfm, ISBN:0721662544] subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "alpha cell of islet of Langerhans" EXACT [] synonym: "pancreatic alpha cell" EXACT [] xref: BTO:0000990 xref: FMA:70585 xref: MESH:D050416 xref: ZFA:0009104 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0002067 ! type A enteroendocrine cell is_a: CL:0008024 ! pancreatic endocrine cell intersection_of: CL:0002067 ! type A enteroendocrine cell intersection_of: BFO:0000050 UBERON:0000006 ! part of islet of Langerhans relationship: BFO:0000050 UBERON:0000006 ! part of islet of Langerhans relationship: RO:0002202 CL:0002351 ! develops from progenitor cell of endocrine pancreas property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/2d-ftu/pancreas-islets-langerhans/v1.2/assets/2d-ftu-pancreas-islets-langerhans.png" xsd:string {terms:licence="http://creativecommons.org/licenses/by/4.0/", xref="doi:10.48539/HBM637.SFSW.654"} property_value: RO:0002175 NCBITaxon:9606 property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0000171" xsd:string {name="pancreatic A cell on CELLxGENE CellGuide"} property_value: terms:description "Pancreatic A cells, also known as alpha cells, are one of the main endocrine cell types found within the islets of Langerhans in the pancreas. Functionally, these cells are pivotal in glucose metabolism and homeostasis, accounting for about 20% of the total population of cells in the islets. Their primary role involves the synthesis, storage, and secretion of the peptide hormone glucagon, which is critical in energy regulation throughout the body. \nIn response to a decrease in blood glucose levels, the pancreatic A cells are stimulated to secrete glucagon into the bloodstream. Glucagon acts on its target cells, mainly in the liver, to stimulate glycogenolysis and gluconeogenesis processes, thereby increasing blood glucose levels back to normal. In this way, pancreatic A cells play an integral role in maintaining glucose homeostasis and preventing hypoglycemia.\nPancreatic A cells also participate in the local regulation of islet activities as glucagon acts through glucagon receptors on A, B and D type cells within the islets. Recent studies have also shown that Pancreatic A cells play a role in the generation and regeneration of B type cells. Following beta cell injuries pancreatic A cells increase in numbers and produce Glucagon-like peptide-1 (GLP-1), which increases the proliferation and cytoprotection of beta cells. In response to extreme injury of B type cells pancreatic A cells can transform (transdifferentiate) into functioning B type cells.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1016/j.beem.2015.10.002", xref="DOI:10.1016/j.semcdb.2020.01.006", xref="DOI:10.1038/nature08894", xref="DOI:10.1210/er.2006-0007", xref="DOI:10.1677/JOE-08-0290"} [Term] id: CL:0000172 name: somatostatin secreting cell def: "Any secretory cell that is capable of some somatostatin secretion." [FBC:Autogenerated] subset: human_subset subset: mouse_subset xref: ZFA:0009105 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000167 ! peptide hormone secreting cell intersection_of: CL:0000151 ! secretory cell intersection_of: RO:0002215 GO:0070253 ! capable of somatostatin secretion relationship: RO:0002215 GO:0070253 ! capable of somatostatin secretion [Term] id: CL:0000173 name: pancreatic D cell def: "A D cell located in the pancreas. Peripherally placed within the islets like type A cells; contains somatostatin." [FMA:0517223651, GOC:tfm] subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "D-cell of pancreatic islet" EXACT [] synonym: "delta cell of islet" EXACT [] synonym: "delta cell of pancreatic islet" EXACT [] synonym: "pancreatic D-cell" EXACT [] synonym: "pancreatic delta cell" EXACT [] synonym: "somatostatin-secreting pancreatic cell" EXACT [] xref: BTO:0000803 xref: FMA:70587 xref: ZFA:0005743 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000502 ! type D enteroendocrine cell is_a: CL:0008024 ! pancreatic endocrine cell intersection_of: CL:0000502 ! type D enteroendocrine cell intersection_of: BFO:0000050 UBERON:0001264 ! part of pancreas relationship: BFO:0000050 UBERON:0000006 ! part of islet of Langerhans relationship: RO:0002202 CL:0002351 ! develops from progenitor cell of endocrine pancreas property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/2d-ftu/pancreas-islets-langerhans/v1.2/assets/2d-ftu-pancreas-islets-langerhans.png" xsd:string {terms:licence="http://creativecommons.org/licenses/by/4.0/", xref="doi:10.48539/HBM637.SFSW.654"} property_value: RO:0002175 NCBITaxon:9606 property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0000173" xsd:string {name="pancreatic D cell on CELLxGENE CellGuide"} property_value: terms:description "Pancreatic D cells, also known as delta cells, are one of the main cell types found in the islets of Langerhans within the pancreas. They represent a minor fraction of the islet cells, comprising about 5% to 10% of the total islet cell population. Their main function is to produce and secrete the peptide hormone somatostatin, an inhibitory hormone that regulates the endocrine system. \nTheir complex morphology, coupled with their distinctive function, sets the pancreatic D cells apart from other cells in the islets of Langerhans. They have long, neurite-like processes which allow them to make contact with other pancreatic endocrine cells at some distance from the cell body and create an extensive paracrine network. \nThe somatostatin secreted by the pancreatic D cells has a variety of inhibitory effects on the secretory activity of other cells within the pancreas and the gastrointestinal system. In the pancreas, one of the principal roles of somatostatin is to inhibit both insulin and glucagon secretion, thereby playing a potent role in the regulation of blood glucose levels. The processes of pancreatic D cells can be >20μm long and may make contact with multiple pancreatic A and B type cells, potentially explaining the secretion of both glucagon and insulin observed in the presence of somatostatin receptor antagonists. The dual inhibitory role makes somatostatin a key player in preventing the excessive action of these hormones and maintaining metabolic balance.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1038/s41467-019-11517-x", xref="DOI:10.1038/s41574-018-0020-6", xref="DOI:10.1369/0022155415583535", xref="https://www.sciencedirect.com/topics/agricultural-and-biological-sciences/delta-cell"} [Term] id: CL:0000174 name: steroid hormone secreting cell def: "Any secretory cell that is capable of some steroid hormone secretion." [FBC:Autogenerated] subset: human_subset subset: mouse_subset xref: ZFA:0009106 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000151 ! secretory cell intersection_of: CL:0000151 ! secretory cell intersection_of: RO:0002215 GO:0035929 ! capable of steroid hormone secretion relationship: RO:0002215 GO:0035929 ! capable of steroid hormone secretion [Term] id: CL:0000175 name: luteal cell def: "A progesterone secreting cell in the corpus luteum. The large luteal cells develop from the granulosa cells. The small luteal cells develop from the theca cells." [MESH:D008184, PMID:31849844] subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "corpus luteum cell" EXACT [PMID:16790079] synonym: "lutein cell" EXACT [] xref: BTO:0003939 xref: FMA:18688 is_a: CL:0000179 ! progesterone secreting cell relationship: BFO:0000050 UBERON:0002512 ! part of corpus luteum property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0000176 name: ecdysteroid secreting cell def: "Any secretory cell that is capable of some ecdysteroid secretion." [FBC:Autogenerated] subset: human_subset subset: mouse_subset is_a: CL:0000174 ! steroid hormone secreting cell intersection_of: CL:0000151 ! secretory cell intersection_of: RO:0002215 GO:0045457 ! capable of ecdysteroid secretion relationship: RO:0002215 GO:0045457 ! capable of ecdysteroid secretion [Term] id: CL:0000177 name: testosterone secreting cell def: "Any secretory cell that is capable of some testosterone secretion." [FBC:Autogenerated] subset: human_subset subset: mouse_subset xref: ZFA:0009107 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000151 ! secretory cell intersection_of: CL:0000151 ! secretory cell intersection_of: RO:0002215 GO:0035936 ! capable of testosterone secretion relationship: RO:0002215 GO:0035936 ! capable of testosterone secretion [Term] id: CL:0000178 name: Leydig cell def: "A Leydig cell is a testosterone-secreting cell in the interstitial area, between the seminiferous tubules, in the testis." [GOC:tfm, PMID:12050120] comment: Note that the Amphibian Anatomy Ontology (AA) has a class 'leydig cells' but this is unrelated subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "interstitial cell" BROAD [] synonym: "interstitial cell of Leydig" EXACT [] xref: BTO:0000755 xref: CALOHA:TS-1150 xref: EMAPA:29655 xref: FMA:72297 xref: MESH:D007985 xref: ZFA:0009108 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: BFO:0000002 is_a: CL:0000177 ! testosterone secreting cell is_a: CL:4030031 ! interstitial cell relationship: BFO:0000050 UBERON:0005212 ! part of Leydig cell region of testis relationship: RO:0002202 CL:0009091 ! develops from Leydig stem cell property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0000178" xsd:string {name="Leydig cell on CELLxGENE CellGuide"} property_value: terms:description "Leydig cells are a testosterone-secreting cell in the interstitial area in the testes of males. They are named after Franz Leydig, a German anatomist who discovered these cells in 1850. Uniquely situated within the soft connective tissue surrounding the seminiferous tubules, Leydig cells form an integral part of the male reproductive system. They are usually polygonal cells characterized by well developed smooth endoplasmic reticulum, high lipid content and a large round nucleus. They are found across mammalian species, including humans. \nThe primary function of Leydig cells is the production of androgens, the male sex hormones, the most notable of which is testosterone. Leydig cells synthesize testosterone from cholesterol through a series of enzymatic reactions. The production and release of testosterone are mainly regulated by the luteinizing hormone (LH) released by the anterior pituitary gland. In response to LH, Leydig cells convert cholesterol into testosterone, which then plays a crucial role in the development and maintenance of primary and secondary male sexual characteristics. These include the formation and maturation of male reproductive organs, onset of spermatogenesis, and the presentation of male secondary sexual traits such as the deepening of the voice, growth of facial hair, development of muscles, and a broadening of shoulders.\nApart from testosterone production, Leydig cells also secrete insulin-like factor 3 (INSL3) that is essential for testicular descent during embryonic development in males. Dysregulation or loss of Leydig cells can lead to numerous conditions like testosterone deficiency, infertility, and certain forms of testicular cancer. Although not typical, Leydig cells can regenerate if they are damaged, ensuring the continuous production of testosterone and maintaining male reproductive health. They provide an excellent model to study cell differentiation and hormone regulation, thereby enhancing our understanding of reproductive biology and associated disorders.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1016/j.coemr.2019.03.001", xref="DOI:10.1093/biolre/ioy059", xref="DOI:10.1210/clinem/dgaa603", xref="DOI:10.3389/fendo.2014.00006", xref="https://www.ncbi.nlm.nih.gov/books/NBK556007/#:~:text=Leydig%20cells%20are%20the%20primary,secondary%20sexual%20characteristics%20and%20behaviors."} [Term] id: CL:0000179 name: progesterone secreting cell def: "Any secretory cell that is capable of some progesterone secretion." [FBC:Autogenerated] subset: human_subset subset: mouse_subset xref: ZFA:0009109 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000174 ! steroid hormone secreting cell is_a: CL:0000255 ! eukaryotic cell intersection_of: CL:0000151 ! secretory cell intersection_of: RO:0002215 GO:0042701 ! capable of progesterone secretion relationship: RO:0002215 GO:0042701 ! capable of progesterone secretion [Term] id: CL:0000180 name: estradiol secreting cell def: "A steroid hormone secreting cell that secretes estradiol." [https://orcid.org/0000-0001-5208-3432] subset: human_subset subset: mouse_subset xref: ZFA:0009110 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000174 ! steroid hormone secreting cell intersection_of: CL:0000151 ! secretory cell intersection_of: RO:0002215 GO:0035938 ! capable of estradiol secretion relationship: RO:0002215 GO:0035938 ! capable of estradiol secretion [Term] id: CL:0000181 name: obsolete metabolising cell def: "A cell whose primary function is intermediary metabolism." [FB:ma] comment: Removing this grouping class, because the groupings are incomplete and too hard to maintain. property_value: IAO:0000233 https://github.com/obophenotype/cell-ontology/issues/720 is_obsolete: true [Term] id: CL:0000182 name: hepatocyte def: "The main structural component of the liver. They are specialized epithelial cells that are organized into interconnected plates called lobules. Majority of cell population of liver, polygonal in shape, arranged in plates or trabeculae between sinusoids; may have single nucleus or binucleated." [GOC:tfm, http://en.wikipedia.org/wiki/Hepatocyte, ISBN:0412046911, MESH:D022781, PMID:19717280] comment: Hepatocytes are reportedly MHC Class I-positive and MHC Class II-positive. subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset xref: BTO:0000575 xref: CALOHA:TS-0454 xref: FMA:14515 xref: ZFA:0009111 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: BFO:0000002 is_a: CL:0000066 ! epithelial cell is_a: CL:0000417 ! endopolyploid cell relationship: BFO:0000050 UBERON:0002107 ! part of liver relationship: RO:0002202 CL:0005026 ! develops from hepatoblast relationship: RO:0002215 GO:0006699 ! capable of bile acid biosynthetic process relationship: RO:0002215 GO:0098754 ! capable of detoxification property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/2d-ftu/liver-liver-lobule/v1.3/assets/2d-ftu-liver-liver-lobule.png" xsd:string {terms:licence="http://creativecommons.org/licenses/by/4.0/", xref="doi:10.48539/HBM889.CJPK.447"} property_value: RO:0002175 NCBITaxon:9606 property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0000182" xsd:string {name="hepatocyte on CELLxGENE CellGuide"} property_value: terms:description "Hepatocytes are the major cell type constituting 70-80% of the liver's cytoplasmic mass, playing crucial roles in maintaining the body's metabolic homeostasis. Dimensions of mature hepatocytes typically range from 20 to 30 μm in humans, but size may vary depending on their location within the liver lobule. Hepatocytes are characterized by high biosynthetic, enzymatic, and endocytic activity. They contain abundant mitochondria, smooth and rough endoplasmic reticulum, peroxisomes, lysosomes, and a large nucleus that is often binucleate. \nThe liver consists of three zones - the periportal Zone 1, midzone 2, and pericentral Zone 3 - which have differential nutrient and oxygen status, and damage susceptibility; hepatocytes in the different zones show signifcant functional heterogeneity ('hepatocyte functional zonation'). Hepatocytes are involved in a multitude of critical functions including the metabolism of lipids, carbohydrates, and proteins, the synthesis of serum proteins (e.g., albumin, transferrin, and lipoproteins), the detoxification and excretion of endogenous and exogenous substances, the storage of vitamins and minerals, and the production and secretion of bile. \nHeterocytes demonstrate a remarkable regenerative capacity, which enables the liver to recover from injury and loss of tissue mass. Notably, hepatocytes perform biotransformation with both phase I and phase II enzymes, which modify drugs, xenobiotics, and various substances for elimination from the body. Phase I enzymes, such as cytochrome P450, catalyze both oxidative and reductive reactions of many xenobiotics; many of the products of phase I enzymes are substrates for the phase II enzymes, which catalyze conjugation reactions. \nAlterations in hepatocyte function have significant implications for overall human health and disease. Certain conditions, such as hepatitis, cirrhosis, and liver cancer, can profoundly affect hepatocyte structure and function, thereby disrupting the liver's ability to perform its vital roles within the body. As the primary site for drug metabolism, changes in hepatocyte function can also impact the effectiveness and toxicity of pharmaceuticals. The regenerative ability of hepatocytes makes them valuable cells for liver regenerative medicine and bioartificial liver support systems, and their study has provided significant insights into liver biology and disease.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1016/j.biocel.2011.11.011", xref="DOI:10.1055/s-2007-1007096", xref="DOI:10.1083/jcb.201903090", xref="DOI:10.1111/j.1439-0396.2007.00752.x"} [Term] id: CL:0000183 name: contractile cell def: "A cell whose primary function is to shorten." [FB:ma] subset: cellxgene_subset subset: human_subset subset: mouse_subset is_a: CL:0000000 ! cell property_value: skos:prefLabel "contractile cell" xsd:string [Term] id: CL:0000185 name: myoepithelial cell def: "Contractile cells resembling smooth muscle cells that are present in glands, notably the mammary gland, and aid in secretion. This cell has long weaving dendritic processes containing myofilament." [GOC:tfm, ISBN:0721662544] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "basket epithelial cell" EXACT [] synonym: "myoepitheliocyte" EXACT [] xref: BTO:0002309 xref: CALOHA:TS-2379 xref: FMA:67799 xref: ZFA:0009113 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000075 ! columnar/cuboidal epithelial cell is_a: CL:0000183 ! contractile cell [Term] id: CL:0000186 name: myofibroblast cell def: "An animal cell that has characteristics of both a fibroblast cell and a smooth muscle cell." [GOC:dsd, GOC:tfm, MESH:D058628, PMID:19800625, PMID:20630469, PMID:22387320] comment: Myofibroblasts are alpha-SMA-positive, CD34-negative, CD45-negative. They are reportedly capable of secreting IL-1beta, IL-6, and TNF-alpha. subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "MFB" EXACT [PMID:8731193] is_a: CL:0000183 ! contractile cell is_a: CL:0002320 ! connective tissue cell property_value: RO:0002175 NCBITaxon:9606 property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0000186" xsd:string {name="myofibroblast cell on CELLxGENE CellGuide"} property_value: terms:description "Myofibroblasts are specialized cells predominantly found within the connective tissues of the body, most notably in areas of injury or wound healing. They carry out a crucial role in many biological processes, including tissue repair and fibrosis, wound contraction, and organogenesis. Though similar to fibroblasts, myofibroblasts can be differentiated by their unique morphological features and the presence of specialized protein bundles called stress fibers.\nMyofibroblasts originate from several cell types based on the physiological condition or the injury context, including local fibroblasts, epithelial cells, and endothelial cells, shedding light onto their plasticity. Upon tissue injury or wound creation, myofibroblasts activate and undergo a transformation process whereby they develop contractile features. They express a type of protein called alpha-smooth muscle actin (α-SMA), allowing them to contract and aid in wound closure. These cells also produce extracellular matrix (ECM) components, primarily collagen, to support and provide structural integrity to the healing tissue.\nHowever, while myofibroblasts play a critical role in normal wound healing, their function can be detrimental in certain pathological conditions. For instance, in chronic diseases such as fibrosis or scarring, the extended presence or overactivity of myofibroblasts can lead to the excessive production of ECM and fibrous tissues, leading to hardened, rigid tissues and organ dysfunction.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1002/path.4104", xref="DOI:10.1038/nrm809", xref="DOI:10.2147/CCID.S50046", xref="DOI:10.3390/biom11081095", xref="DOI:10.7860/JCDR/2014/7820.4231"} [Term] id: CL:0000187 name: muscle cell def: "A mature contractile cell, commonly known as a myocyte. This cell has as part of its cytoplasm myofibrils organized in various patterns." [MESH:D032342] subset: cellxgene_subset subset: general_cell_types_upper_slim subset: human_subset subset: mouse_subset synonym: "muscle fiber" EXACT [] synonym: "myocyte" EXACT [] xref: BTO:0000888 xref: BTO:0000902 xref: CALOHA:TS-2032 xref: FBbt:00005074 {sssom:mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"} xref: FMA:67328 xref: WBbt:0003675 xref: ZFA:0009114 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: BFO:0000002 is_a: CL:0000183 ! contractile cell is_a: CL:0000255 ! eukaryotic cell is_a: CL:0000393 ! electrically responsive cell relationship: RO:0002202 CL:0000056 ! develops from myoblast property_value: foaf:depiction "https://www.swissbiopics.org/api/image/Muscle_cells.svg" xsd:anyURI property_value: skos:prefLabel "muscle cell" xsd:string [Term] id: CL:0000188 name: cell of skeletal muscle def: "A somatic cell located in skeletal muscle." [GOC:tfm] subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "skeletal muscle cell" EXACT [] xref: BTO:0004392 xref: CALOHA:TS-2158 xref: FMA:9727 xref: ZFA:0009115 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000255 ! eukaryotic cell intersection_of: CL:0000000 ! cell intersection_of: BFO:0000050 UBERON:0001134 ! part of skeletal muscle tissue relationship: BFO:0000050 UBERON:0001134 ! part of skeletal muscle tissue property_value: RO:0002175 NCBITaxon:9606 property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0000188" xsd:string {name="cell of skeletal muscle on CELLxGENE CellGuide"} property_value: skos:prefLabel "cell of skeletal muscle" xsd:string property_value: terms:description "Skeletal muscle cells, or myocytes, are essential for the musculoskeletal system, featuring a striated appearance from tightly packed sarcomeres. These elongated, multi-nucleated cells convert ATP into mechanical energ and are key for voluntary movement and posture. They also are responsible for maintaining body temperature, storing nutrients, and stabilizing joints.\nSkeletal muscle cells organize themselves tightly into bundles to form muscle fibers. Embedded within each of these cells are thousands of myofibrils, which are made up of the contractile proteins, actin (the thin filament), and myosin (the thick filament). Contraction of a skeletal muscle cell occurs when these myofibrils shorten, a process driven by the sliding of actin and myosin filaments over each other in a mechanism famously known as the sliding filament theory.\nAdditionally, skeletal muscle cells exhibit a high degree of plasticity, which allows for their adaptation in response to alterations in functional demands or damages. They have an innate regenerative capacity due to the presence of satellite cells—quiescent muscle stem cells that reside within the muscle fibers. Upon muscle injury, these satellite cells become activated, proliferate, and differentiate into new muscle cells, thereby contributing to the repair and growth of injured skeletal muscle. With this, skeletal muscle cells serve not only a pivotal biomechanical function but also possess a great capacity for self-healing and regeneration.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1002/cphy.c160033", xref="DOI:10.3390/biology10101056", xref="https://www.nature.com/scitable/topicpage/the-sliding-filament-theory-of-muscle-contraction-14567666/", xref="https://www.ncbi.nlm.nih.gov/books/NBK537139", xref="https://www.ncbi.nlm.nih.gov/books/NBK9961/"} [Term] id: CL:0000189 name: slow muscle cell def: "A muscle cell that develops tension more slowly than a fast-twitch fiber." [GOC:tfm, ISBN:0323052908] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "slow muscle fiber" RELATED [ISBN:0815316208] xref: ZFA:0009116 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0008046 ! extrafusal muscle fiber relationship: RO:0002202 CL:0000857 ! develops from slow muscle myoblast property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0000189" xsd:string {name="slow muscle cell on CELLxGENE CellGuide"} property_value: terms:description "Slow muscle cells, as the name implies, are a type of muscle cell well known for their slow contractile speed. They are also referred to as type I, slow-twitch, or red muscles because of their high myoglobin content which gives them a dark, reddish appearance. These cells are predominantly found in the postural muscles of the body, such as those in the back and lower limbs. \nA defining characteristic of slow muscle cells is their significant resistance to fatigue. This is largely due to their efficient oxidative metabolism, which allows them to continuously contract over extended periods without succumbing to fatigue. This extraordinary endurance is facilitated by a high concentration of mitochondria, which enables the efficient use of oxygen for energy production, and capillaries, which supplies the necessary oxygen and nutrients. Additionally, these cells have an abundant supply of myoglobin, a protein that stores and transports oxygen within the muscle cell, further supporting their aerobic metabolism.\nThe primary role of slow muscle cells in the human body is to provide sustained, low-intensity contractions over a prolonged period. They are responsible for maintaining posture and providing stability, rather than delivering short, powerful bursts of activity. They play a pivotal role in supporting various physical activities such as standing, walking, or any form of exercise that requires endurance over speed.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1093/ptj/81.11.1810", xref="DOI:10.1186/s13578-015-0054-6", xref="DOI:10.3389/fphys.2021.747214", xref="https://www.sciencedirect.com/topics/biochemistry-genetics-and-molecular-biology/slow-muscle-fiber"} [Term] id: CL:0000190 name: fast muscle cell def: "A muscle cell that can develop high tension rapidly. It is usually innervated by a single alpha neuron." [GOC:tfm, ISBN:0323052908] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "glycolytic muscle fiber" EXACT [] xref: ZFA:0009117 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0008046 ! extrafusal muscle fiber relationship: RO:0002202 CL:0000858 ! develops from fast muscle myoblast property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0000190" xsd:string {name="fast muscle cell on CELLxGENE CellGuide"} property_value: terms:description "Fast muscle cells, also known as type II muscle fibers, are a particular type of muscle cell that specializes in conducting rapid, high-intensity contractions. These cells are primarily found within skeletal muscle groups that are directly involved in gross motor activities, such as running, jumping, or lifting heavy weights. The designation \"fast\" refers to their speed of contraction in response to neural stimuli, which is significantly quicker when compared to other muscle cell types such as slow-twitch or type I muscle fibers.\nThe primary function of fast muscle cells revolves around their role in anaerobic metabolism, which provides the energy needed for short, forceful bursts of power. They contain a high concentration of glycolytic enzymes that facilitate this process, leading to a swift break down of glucose to generate ATP (adenosine triphosphate), the primary energy currency in biological systems. On the downside, the byproduct of this very rapid, anaerobic metabolic process is lactic acid, which can build up and cause muscle fatigue. \nFast muscle cells can be further classified into two subtypes based on their metabolic characteristics: type IIa and type IIb/x. Type IIa cells, also known as fast oxidative-glycolytic fibers, possess a good oxygen supply and can function in both anaerobic and aerobic conditions, exhibiting moderate resistance to fatigue. On the other hand, type IIb/x cells, also known as fast glycolytic fibers, primarily rely on anaerobic metabolism and tire out a lot quicker. Both these subtypes can adapt to changing demands due to exercise and conditioning, highlighting the plasticity that is a key characteristic of these versatile muscle cells.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1152/japplphysiol.00636.2019", xref="DOI:10.3389/fcell.2018.00125", xref="DOI:10.4161/org.4.3.6312", xref="https://www.sciencedirect.com/topics/biochemistry-genetics-and-molecular-biology/fast-muscle-fiber"} [Term] id: CL:0000192 name: smooth muscle cell alt_id: CL:0000191 def: "A non-striated, elongated, spindle-shaped cell found lining the digestive tract, uterus, and blood vessels. They develop from specialized myoblasts (smooth muscle myoblast)." [http://en.wikipedia.org/wiki/Smooth_muscle_cell, MESH:D032389, PMID:9315361] subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "myocytes, smooth muscle" EXACT [MESH:D032389] synonym: "non-striated muscle cell" BROAD [] synonym: "SMCs" EXACT [PMID:9315361] synonym: "smooth muscle fiber" EXACT [] xref: BTO:0004576 xref: CALOHA:TS-2159 xref: FMA:14072 xref: ZFA:0009118 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0008000 ! non-striated muscle cell is_a: CL:0008007 ! visceral muscle cell relationship: RO:0002202 CL:0000514 ! develops from smooth muscle myoblast property_value: RO:0002175 NCBITaxon:9606 property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0000192" xsd:string {name="smooth muscle cell on CELLxGENE CellGuide"} property_value: skos:prefLabel "smooth muscle cell" xsd:string property_value: terms:description "Smooth muscle cells are a specialized type of muscle cells that are primarily found within the walls of hollow organs such as the intestine, stomach, bladder, uterus, and blood vessels. These cells are an essential component of the autonomic nervous system controling involuntary movements within the body.\nSmooth muscle cells play a vital role in many physiological processes due to their unique functionality. They can contract and relax in a slow, sustained, and controlled manner to help modulate the size and shape of the lumens of the organs they surround. For example, in the digestive system, coordinated contraction and relaxation of smooth muscle cells propels food along the gastrointestinal tract - a process known as peristalsis. In the blood vessels, the smooth muscle cells, by contracting or relaxing, either constrict or dilate the vessels, which in turn, help regulate blood flow and pressure.\nOn a cellular level, smooth muscle cells possess a single, centrally located nucleus and contain an arranged network of actin and myosin filaments, which are the proteins responsible for muscle contraction. Unlike their counterparts in skeletal or cardiac muscles, these cells lack specific contact points for these filaments, hence the lack of visible striations. Furthermore, the contraction of smooth muscle cells is regulated by hormones and neurotransmitters, such as acetylcholine and norepinephrine, adding an additional layer of complex regulation to these highly specialized cells.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1093/ptj/81.11.1810", xref="https://training.seer.cancer.gov/anatomy/muscular/types.html", xref="https://www.ncbi.nlm.nih.gov/books/NBK10854/", xref="https://www.ncbi.nlm.nih.gov/books/NBK526125", xref="https://www.ncbi.nlm.nih.gov/books/NBK556137/"} [Term] id: CL:0000193 name: cardiac muscle cell (sensu Arthopoda) alt_id: CL:0000466 def: "A striated muscle cell of an arthropod heart that participates in heart contraction." [MESH:D032383] is_a: CL:0000746 ! cardiac muscle cell intersection_of: CL:0000746 ! cardiac muscle cell intersection_of: RO:0002202 CL:0000465 ! develops from cardioblast (sensu Arthropoda) relationship: RO:0002202 CL:0000465 ! develops from cardioblast (sensu Arthropoda) [Term] id: CL:0000194 name: obsolete nodal cardiac cell comment: Consider CL:0002072. is_obsolete: true [Term] id: CL:0000195 name: obsolete Purkinje fiber is_obsolete: true [Term] id: CL:0000196 name: insect flight muscle cell def: "A muscle cell that is involved in the mechanism of insect flight. This encompasses both, cells that power flight and cells that control flight." [doi:10.2142/biophysics.7.21] subset: human_subset subset: mouse_subset xref: FBbt:00003360 {sssom:mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"} is_a: CL:0008003 ! somatic muscle myotube [Term] id: CL:0000197 name: sensory receptor cell def: "A cell that is capable of detection of a stimulus involved in sensory perception." [] subset: human_subset subset: mouse_subset synonym: "receptor cell" EXACT [] xref: MESH:D011984 is_a: CL:0000255 ! eukaryotic cell intersection_of: CL:0000000 ! cell intersection_of: BFO:0000050 UBERON:0001032 ! part of sensory system intersection_of: RO:0002215 GO:0050906 ! capable of detection of stimulus involved in sensory perception relationship: BFO:0000050 UBERON:0001032 ! part of sensory system relationship: RO:0002215 GO:0050906 ! capable of detection of stimulus involved in sensory perception property_value: skos:prefLabel "sensory receptor cell" xsd:string [Term] id: CL:0000198 name: pain receptor cell def: "The peripheral receptor for pain. Includes receptors which are sensitive to painful mechanical stimuli, extreme heat or cold, and chemical stimuli. All mammalian nociceptors are free nerve endings." [MESH:D009619] comment: Editor note: request detection of stimulus involved in sensory perception of pain; add develops_from relationship subset: human_subset subset: mouse_subset synonym: "nociceptor" EXACT [] {seeAlso="https://meshb.nlm.nih.gov/record/ui?ui=D009619"} synonym: "nocireceptor" EXACT [] {seeAlso="https://www.thefreedictionary.com/nocireceptor"} xref: ZFA:0009119 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000006 ! neuronal receptor cell [Term] id: CL:0000199 name: mechanoreceptor cell def: "A cell specialized to transduce mechanical stimuli and relay that information centrally in the nervous system." [MESH:D008465] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "mechanoreceptor" RELATED [MP:0000972] xref: ZFA:0009120 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000101 ! sensory neuron intersection_of: CL:0000540 ! neuron intersection_of: RO:0002215 GO:0050974 ! capable of detection of mechanical stimulus involved in sensory perception relationship: RO:0002215 GO:0050974 ! capable of detection of mechanical stimulus involved in sensory perception [Term] id: CL:0000200 name: touch receptor cell def: "Any neuron that is capable of some detection of mechanical stimulus involved in sensory perception of touch." [FBC:Autogenerated] subset: human_subset subset: mouse_subset is_a: CL:0000199 ! mechanoreceptor cell intersection_of: CL:0000540 ! neuron intersection_of: RO:0002215 GO:0050976 ! capable of detection of mechanical stimulus involved in sensory perception of touch relationship: RO:0002215 GO:0050976 ! capable of detection of mechanical stimulus involved in sensory perception of touch [Term] id: CL:0000202 name: auditory hair cell alt_id: CL:0000201 def: "A mechanoreceptor cell of the auditory or vestibular system that is sensitive to auditory stimuli. The accessory sensory structures are arranged so that appropriate stimuli cause movement of the hair-like projections (stereocilia and kinocilia) which relay the information centrally in the nervous system." [MESH:D006198, WikipediaVersioned:Hair_cell&oldid=1045345915] comment: In mammals these cells are located in the organ of Corti. subset: human_subset subset: mouse_subset synonym: "auditory receptor cell" RELATED [] xref: ZFA:0009121 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000855 ! sensory hair cell relationship: RO:0002215 GO:0050910 ! capable of detection of mechanical stimulus involved in sensory perception of sound [Term] id: CL:0000203 name: gravity sensitive cell def: "Any neuronal receptor cell that is capable of some detection of mechanical stimulus involved in sensory perception of gravity." [FBC:Autogenerated] subset: human_subset subset: mouse_subset is_a: CL:0000006 ! neuronal receptor cell is_a: CL:0000199 ! mechanoreceptor cell intersection_of: CL:0000006 ! neuronal receptor cell intersection_of: RO:0002215 GO:0070999 ! capable of detection of mechanical stimulus involved in sensory perception of gravity relationship: RO:0002215 GO:0070999 ! capable of detection of mechanical stimulus involved in sensory perception of gravity [Term] id: CL:0000204 name: acceleration receptive cell subset: human_subset subset: mouse_subset is_a: CL:0000006 ! neuronal receptor cell [Term] id: CL:0000205 name: thermoreceptor cell def: "A cellular receptor which mediates the sense of temperature. Thermoreceptor cells in vertebrates are mostly located under the skin. In mammals there are separate types of thermoreceptors for cold and for warmth and pain receptor cells which detect cold or heat extreme enough to cause pain." [GOC:tfm, MESH:D013823, MP:0000971] subset: human_subset subset: mouse_subset xref: ZFA:0009123 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000006 ! neuronal receptor cell intersection_of: CL:0000006 ! neuronal receptor cell intersection_of: RO:0002215 GO:0050960 ! capable of detection of temperature stimulus involved in thermoception relationship: RO:0002215 GO:0050960 ! capable of detection of temperature stimulus involved in thermoception [Term] id: CL:0000206 name: chemoreceptor cell def: "A cell specialized to detect chemical substances and relay that information centrally in the nervous system. Chemoreceptors may monitor external stimuli, as in taste and olfaction, or internal stimuli, such as the concentrations of oxygen and carbon dioxide in the blood." [MESH:D002628] subset: human_subset subset: mouse_subset xref: ZFA:0009124 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000197 ! sensory receptor cell intersection_of: CL:0000197 ! sensory receptor cell intersection_of: RO:0002215 GO:0050907 ! capable of detection of chemical stimulus involved in sensory perception relationship: RO:0002215 GO:0050907 ! capable of detection of chemical stimulus involved in sensory perception property_value: skos:prefLabel "chemoreceptor cell" xsd:string [Term] id: CL:0000207 name: olfactory receptor cell def: "Any neuron that is capable of some detection of chemical stimulus involved in sensory perception of smell." [FBC:Autogenerated] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "odorant receptor cell" EXACT [] synonym: "olfactory receptor neuron" EXACT [] synonym: "olfactory sensory neuron" EXACT [] synonym: "Schultze's cell" EXACT [] xref: BTO:0004185 xref: FMA:67860 xref: MESH:D018034 xref: Wikipedia:Olfactory_receptor_neuron xref: ZFA:0009125 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000006 ! neuronal receptor cell is_a: CL:0000206 ! chemoreceptor cell intersection_of: CL:0000540 ! neuron intersection_of: RO:0002215 GO:0050911 ! capable of detection of chemical stimulus involved in sensory perception of smell relationship: BFO:0000050 UBERON:0005725 ! part of olfactory system relationship: RO:0002215 GO:0050911 ! capable of detection of chemical stimulus involved in sensory perception of smell property_value: skos:prefLabel "olfactory receptor cell" xsd:string [Term] id: CL:0000208 name: pH receptor cell subset: human_subset subset: mouse_subset is_a: CL:0000206 ! chemoreceptor cell [Term] id: CL:0000209 name: taste receptor cell def: "A specialized cell involved in gustatory sensory perception." [GOC:tfm, ISBN:0618947256] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "taste bud cell" EXACT [] xref: FMA:67910 xref: ZFA:0009126 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000098 ! sensory epithelial cell is_a: CL:0000206 ! chemoreceptor cell is_a: CL:0002076 ! endo-epithelial cell intersection_of: CL:0000206 ! chemoreceptor cell intersection_of: RO:0002215 GO:0050912 ! capable of detection of chemical stimulus involved in sensory perception of taste relationship: RO:0002215 GO:0050912 ! capable of detection of chemical stimulus involved in sensory perception of taste property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0000209" xsd:string {name="taste receptor cell on CELLxGENE CellGuide"} property_value: skos:prefLabel "taste receptor cell" xsd:string property_value: terms:description "Taste receptor cells, also known as gustatory receptor cells, are specialized epithelial cells that are responsible for detecting taste stimuli. They also play a role in regulating feeding behavior and nutrient intake by signaling the presence of nutrients or toxins in food. \nThese cells are located in taste buds, which are small structures found on the tongue, palate, and throat. Each taste bud is composed of 50-100 taste receptor cells, as well as supporting cells and basal cells.\nTaste receptor cells are involved in the transduction of taste stimuli into neural signals that can be interpreted by the brain. They detect five primary tastes: sweet, sour, salty, umami (savory), and bitter. Each taste receptor cell is specialized to detect one or more of these tastes, depending on the expression of specific taste receptors on their membrane. For example, sweet taste receptors bind to sugars and artificial sweeteners, while bitter taste receptors recognize many toxins and alkaloids. Mechanistically, when a taste receptor cell is stimulated by a tastant, it depolarizes and releases neurotransmitters that activate sensory nerve fibers, which then transmit the information to the brain.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1038/nrendo.2015.7", xref="DOI:10.1038/nrn.2017.68", xref="DOI:10.1111/j.1748-1716.2011.02308.x"} [Term] id: CL:0000210 name: photoreceptor cell def: "A cell specialized in detecting light stimuli that are involved in visual perception." [MESH:D010786] subset: cellxgene_subset subset: human_subset subset: mouse_subset xref: BTO:0001060 xref: CALOHA:TS-0868 xref: FBbt:00004211 {sssom:mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"} xref: FMA:86740 xref: ZFA:0009127 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000101 ! sensory neuron is_a: CL:0008028 ! visual system neuron intersection_of: CL:0000540 ! neuron intersection_of: RO:0002215 GO:0050908 ! capable of detection of light stimulus involved in visual perception relationship: RO:0002215 GO:0050908 ! capable of detection of light stimulus involved in visual perception property_value: foaf:depiction "https://www.swissbiopics.org/api/image/Photoreceptor_cell.svg" xsd:anyURI property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0000210" xsd:string {name="photoreceptor cell on CELLxGENE CellGuide"} property_value: skos:prefLabel "photoreceptor cell" xsd:string property_value: terms:description "Photoreceptor cells are specialized types of neurons found in the retina, responsible for the vital task of converting light into signals that can stimulate a visual response. These cells are called photoreceptor cells because they are light-sensitive, enabling vision in conditions ranging from extremely dim to very bright light. There are two main types of photoreceptor cells in the human eye: rods, which are highly sensitive to light and allow for vision in low-light conditions, and cones, which are responsible for color vision and function best in bright light.\nThe photoreceptor cells function by absorbing light rays and converting them into electrical signals. These signals are then sent to the brain via the optic nerve and are interpreted as visual images. This process begins when the photopigment (a light-sensitive compound) found in photoreceptor cells absorbs light, which triggers a chemical reaction. This reaction leads to changes in the photopigment's configuration and, consequently, alters its electrical properties. This change initiates a signal that is transmitted through the cell and onwards to connecting neurons.\nFurthermore, photoreceptor cells exhibit a unique and highly specialized structure that reflects their function. Rods, named because of their elongated, rod-shaped structure, consist of an outer segment filled with disks containing rhodopsin, the photopigment responsible for detecting light. Cones, on the other hand, are more conical and have three different types of photopigments, each one sensitive to a different range of wavelengths, allowing for the perception of color. Given the importance of photoreceptor cells in vision, damage or degeneration to these cells can lead to vision impairment or blindness, highlighting their key role in visual perception.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1016/j.cbpa.2008.04.600", xref="DOI:10.1016/j.neubiorev.2017.12.006", xref="DOI:10.1038/nrg2717", xref="DOI:10.1113/JP282058", xref="DOI:10.1242/jcs.175687"} [Term] id: CL:0000211 name: electrically active cell def: "A cell whose function is determined by the generation or the reception of an electric signal." [FB:ma] subset: human_subset subset: mouse_subset xref: ZFA:0009128 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000000 ! cell property_value: skos:prefLabel "electrically active cell" xsd:string [Term] id: CL:0000212 name: obsolete absorptive cell def: "OBSOLETE. A cell that takes up and metabolizes substances." [CL:CVS] comment: It has no child terms. Consider using 'gut absorptive cell'. subset: human_reference_atlas property_value: IAO:0000233 https://github.com/obophenotype/cell-ontology/issues/2271 property_value: RO:0002175 NCBITaxon:9606 is_obsolete: true [Term] id: CL:0000213 name: obsolete lining cell def: "OBSOLETE. A cell within an epithelial cell sheet whose main function is to act as an internal or external covering for a tissue or an organism." [JB:jb] comment: Obsoleted term because redundant synonym: "boundary cell" EXACT [] property_value: IAO:0000233 https://github.com/obophenotype/cell-ontology/issues/3014 is_obsolete: true [Term] id: CL:0000214 name: synovial cell def: "A cell located in the synovial joint." [] subset: human_subset subset: mouse_subset synonym: "synoviocyte" EXACT [] xref: CALOHA:TS-0995 xref: ZFA:0009131 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0002078 {is_inferred="true"} ! meso-epithelial cell relationship: BFO:0000050 UBERON:0002217 ! part of synovial joint [Term] id: CL:0000215 name: obsolete barrier cell def: "OBSOLETE. A cell whose primary function is to prevent the transport of stuff across compartments." [JB:jb] comment: Not needed term property_value: IAO:0000233 https://github.com/obophenotype/cell-ontology/issues/3012 is_obsolete: true [Term] id: CL:0000216 name: Sertoli cell def: "A supporting cell projecting inward from the basement membrane of seminiferous tubules. They surround and nourish the developing male germ cells and secrete androgen binding protein. Their tight junctions with the spermatogonia and spermatocytes provide a blood-testis barrier." [MESH:D012708] subset: cellxgene_subset subset: human_subset subset: mouse_subset xref: BTO:0001238 xref: CALOHA:TS-0922 xref: FMA:72298 xref: VHOG:0001348 xref: ZFA:0009133 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000511 ! androgen binding protein secreting cell is_a: CL:0000630 {is_inferred="true"} ! supporting cell is_a: CL:0002625 ! seminiferous tubule epithelial cell is_a: CL:1100001 ! secretory epithelial cell intersection_of: CL:0000630 ! supporting cell intersection_of: BFO:0000050 UBERON:0001343 ! part of seminiferous tubule of testis property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0000216" xsd:string {name="Sertoli cell on CELLxGENE CellGuide"} property_value: terms:description "Sertoli cells, also known as sustentacular cells, are epithelial cells that play a crucial part of the male reproductive system and are situated within the seminiferous tubules of the testes. Functionally, Sertoli cells play diverse and pivotal roles in supporting spermatogenesis, the intricate process of sperm production. To scaffold the developing sperm cells, Sertoli cells morphologically change, interacting directly with the germ cells to provide nutritional support, metabolic regulation, and waste removal, thereby creating an environment conducive to the development of germ cells.\nIn addition to their structural function, Sertoli cells also secrete several bioactive molecules with crucial implications for spermatogenesis. These include anti-mullerian hormone (AMH) during fetal life, inhibin, and androgen binding protein (ABP), as well as several growth factors and transport proteins. They also contribute to the immune-privileged status of the testes by forming the blood-testis barrier, safeguarding sperm antigens from the systemic immune response. Given their extensive roles in maintaining testicular function, impairments in Sertoli cell function can lead to male infertility and are implicated in a range of related disorders.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1016/j.semcdb.2021.06.016", xref="DOI:10.1038/s41419-019-1782-z", xref="https://www.ncbi.nlm.nih.gov/books/NBK560631/"} [Term] id: CL:0000217 name: obsolete insulating cell comment: obsoleted because the term is not needed property_value: IAO:0000233 https://github.com/obophenotype/cell-ontology/issues/3013 is_obsolete: true [Term] id: CL:0000218 name: myelinating Schwann cell def: "A neuroglial cell of the peripheral nervous system which forms the insulating myelin sheaths of peripheral axons." [GOC:cvs, GOC:tfm, MESH:D012583] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "neurilemmal cell" EXACT [] synonym: "peripheral neuroglial cell" BROAD [] synonym: "Schwann cell" BROAD [] xref: CALOHA:TS-0898 xref: FMA:62121 xref: ZFA:0009135 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0002573 ! Schwann cell is_a: CL:4023154 ! myelinating glial cell relationship: RO:0002202 CL:0002377 ! develops from immature Schwann cell [Term] id: CL:0000219 name: motile cell def: "A cell that moves by its own activities." [FB:ma] subset: human_subset subset: mouse_subset xref: ZFA:0009136 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000000 ! cell intersection_of: CL:0000000 ! cell intersection_of: RO:0002215 GO:0048870 ! capable of cell motility relationship: RO:0002215 GO:0048870 ! capable of cell motility property_value: skos:prefLabel "motile cell" xsd:string [Term] id: CL:0000220 name: obsolete cell by lineage comment: This term was made obsolete because there is no difference in meaning between it and 'cell', as any cell in a multicellular organiam, apart from a zygote, can potentially be classified by its lineage. If you have used this term in annotation, please replace it with cell (CL:0000000), native cell (CL:0000003), or cell in vitro (CL:0001034) as appropriate. is_obsolete: true consider: CL:0000000 consider: CL:0000003 consider: CL:0001034 [Term] id: CL:0000221 name: ectodermal cell def: "A cell of the outer of the three germ layers of the embryo." [MESH:D004475] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "ectoderm cell" EXACT [] xref: FMA:72549 xref: ZFA:0009137 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000255 ! eukaryotic cell is_a: CL:0002321 ! embryonic cell (metazoa) relationship: BFO:0000050 UBERON:0000924 ! part of ectoderm property_value: skos:prefLabel "ectodermal cell" xsd:string [Term] id: CL:0000222 name: mesodermal cell def: "A cell of the middle germ layer of the embryo." [MESH:D008648] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "mesoblast" EXACT [] synonym: "mesoderm cell" EXACT [] xref: FMA:72554 xref: ZFA:0009138 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000255 ! eukaryotic cell is_a: CL:0002321 ! embryonic cell (metazoa) relationship: BFO:0000050 UBERON:0000926 ! part of mesoderm property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0000222" xsd:string {name="mesodermal cell on CELLxGENE CellGuide"} property_value: skos:prefLabel "mesodermal cell" xsd:string property_value: terms:description "Mesodermal cells are pluripotent and the most abundant in the human body. They contribute to the development of several structures such as the skeletal muscles, bones, heart and blood vessels, kidneys, gonads, connective tissues, and certain layers of the skin. Hence, the mesoderm is often regarded as an active and diverse layer due to its role in forming many bodily structures. \nIn embryonic development, these cells are instrumental, contributing to the body's structures through a carefully coordinated sequence of morphogenetic movements. This process forms the complex multicellular architecture of tissues and organs from a simple ball of cells. Without the function of mesodermal cells, the body's integral structures and systems would cease to form correctly, leading to developmental disorders such as axial mesodermal dysplasia complex\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1016/j.ceb.2019.07.012", xref="DOI:10.5535/arm.2016.40.1.162", xref="https://www.sciencedirect.com/topics/biochemistry-genetics-and-molecular-biology/mesoderm"} [Term] id: CL:0000223 name: endodermal cell def: "A cell of the inner of the three germ layers of the embryo." [MESH:D004707] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "endoderm cell" EXACT [] xref: FMA:72555 xref: ZFA:0009139 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000255 ! eukaryotic cell is_a: CL:0002321 ! embryonic cell (metazoa) relationship: BFO:0000050 UBERON:0000925 ! part of endoderm property_value: skos:prefLabel "endodermal cell" xsd:string [Term] id: CL:0000224 name: obsolete cell by nuclear number def: "OBSOLETE: A classification of cells by the number of their nuclei." [FB:ma, GOC:tfm] comment: This term was made obsolete because there is no difference in meaning between it and 'cell', as any cell can be classified by its nuclear number (note that this term was previously used as a parent class of enucleate cell). If you have used this term in annotation, please replace it with cell (CL:0000000), native cell (CL:0000003), or cell in vitro (CL:0001034) as appropriate. is_obsolete: true consider: CL:0000000 consider: CL:0000003 consider: CL:0001034 [Term] id: CL:0000225 name: anucleate cell def: "A cell that lacks a nucleus." [FB:ma] subset: human_subset subset: mouse_subset synonym: "non-nucleated cell" EXACT [] xref: FMA:68647 is_a: CL:0000000 ! cell intersection_of: CL:0000000 ! cell intersection_of: RO:0000053 PATO:0001405 ! has characteristic anucleate disjoint_from: CL:0002242 ! nucleate cell relationship: RO:0000053 PATO:0001405 ! has characteristic anucleate [Term] id: CL:0000226 name: single nucleate cell def: "A cell with a single nucleus." [FB:ma, GOC:tfm] subset: human_subset subset: mouse_subset is_a: CL:0000255 ! eukaryotic cell is_a: CL:0002242 ! nucleate cell intersection_of: CL:0000000 ! cell intersection_of: RO:0000053 PATO:0001407 ! has characteristic mononucleate relationship: RO:0000053 PATO:0001407 ! has characteristic mononucleate [Term] id: CL:0000227 name: binucleate cell def: "Any cell that has characteristic some binucleate." [FBC:Autogenerated] subset: human_subset subset: mouse_subset is_a: CL:0000228 ! multinucleate cell intersection_of: CL:0000000 ! cell intersection_of: RO:0000053 PATO:0001406 ! has characteristic binucleate relationship: RO:0000053 PATO:0001406 ! has characteristic binucleate [Term] id: CL:0000228 name: multinucleate cell def: "A cell with more than one nucleus." [FB:ma, Wikipedia:Multinucleate] subset: human_subset subset: mouse_subset synonym: "multinucleated cells" EXACT [Wikipedia:Multinucleate] synonym: "polynuclear cells" EXACT [Wikipedia:Multinucleate] is_a: CL:0000255 ! eukaryotic cell is_a: CL:0002242 ! nucleate cell intersection_of: CL:0000000 ! cell intersection_of: RO:0000053 PATO:0001908 ! has characteristic multinucleate relationship: RO:0000053 PATO:0001908 ! has characteristic multinucleate property_value: skos:prefLabel "multinucleate cell" xsd:string [Term] id: CL:0000229 name: obsolete lymphoblast def: "OBSOLETE (was not defined before being made obsolete)." [] comment: Refers to an activated mature lymphocyte phenotype rather than a distinct cell type; consider using 'lymphocyte ; CL:0000542' or one of its children instead. is_obsolete: true [Term] id: CL:0000230 name: obsolete T lymphoblast def: "OBSOLETE (was not defined before being made obsolete)." [] comment: Refers to an activated mature T lymphocyte phenotype rather than a distinct cell type; consider using 'T cell ; CL:0000084' or one of its children instead. is_obsolete: true [Term] id: CL:0000231 name: obsolete B lymphoblast def: "OBSOLETE (was not defined before being made obsolete)." [] comment: Refers to an activated mature B lymphocyte phenotype rather than a distinct cell type; consider using 'B cell ; CL:0000236' or one of its children instead. is_obsolete: true [Term] id: CL:0000232 name: erythrocyte def: "A red blood cell. In mammals, mature erythrocytes are biconcave disks containing hemoglobin whose function is to transport oxygen." [GOC:tfm, MESH:D004912] subset: blood_and_immune_upper_slim subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "RBC" EXACT [] synonym: "red blood cell" EXACT [] xref: BTO:0000424 xref: CALOHA:TS-0290 xref: FMA:81100 is_a: CL:0000081 ! blood cell is_a: CL:0000329 ! oxygen accumulating cell is_a: CL:0000764 {is_inferred="true"} ! erythroid lineage cell intersection_of: CL:0000764 ! erythroid lineage cell intersection_of: CL:4030045 GO:0005840 ! lacks_part ribosome intersection_of: CL:4030046 PR:000001945 ! lacks_plasma_membrane_part transferrin receptor protein 1 intersection_of: RO:0000053 PATO:0002039 ! has characteristic biconcave intersection_of: RO:0002215 GO:0008015 ! capable of blood circulation intersection_of: RO:0002215 GO:0015671 ! capable of oxygen transport relationship: CL:4030045 GO:0005840 ! lacks_part ribosome relationship: CL:4030046 PR:000001945 ! lacks_plasma_membrane_part transferrin receptor protein 1 relationship: RO:0000053 PATO:0002039 ! has characteristic biconcave relationship: RO:0002202 CL:0000558 ! develops from reticulocyte property_value: RO:0002175 NCBITaxon:9606 property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0000232" xsd:string {name="erythrocyte on CELLxGENE CellGuide"} property_value: skos:prefLabel "erythrocyte" xsd:string property_value: terms:description "Erythrocytes, also known as red blood cells, are a type of specialized cell that make up the largest percentage of cells in the human body. Erythrocytes are biconcave in shape and lack nuclei and organelles, allowing them to carry oxygen and carbon dioxide through the bloodstream more efficiently. The main function of erythrocytes is to transport oxygen from the lungs to the body's tissues and organs, and to transport carbon dioxide from the body's tissues to the lungs, where it can be exhaled out of the body. Hemoglobin, a protein located inside erythrocytes, is responsible for binding to oxygen. \nErythrocytes are produced in the bone marrow and have a lifespan of approximately 120 days before they are broken down and recycled by the body. Erythrocytes are regulated by the hormone erythropoietin, which is produced by the kidneys and liver in response to low oxygen levels in the body, thereby stimulating erythrocyte production .\nIn addition to their role in oxygen transport, erythrocytes also play a key role in regulating the body's pH levels. Without erythrocytes, oxygen would not be able to be transported efficiently throughout the body and tissues would not receive the necessary oxygen to function properly. Overall, erythrocytes are essential for maintaining the health and homeostasis of the body.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1016/j.blre.2012.12.003", xref="DOI:10.1056/NEJM199801223380407", xref="DOI:10.3389/fphys.2021.655393"} [Term] id: CL:0000233 name: platelet def: "A non-nucleated disk-shaped cell formed by extrusion from megakaryocytes, found in the blood of all mammals, and mainly involved in blood coagulation." [GOC:add, GOC:dsd, GOC:tfm, http://en.wikipedia.org/wiki/Platelet, MESH:D001792, PMID:11110672, PMID:16987572, PMID:17204662, PMID:17479180, PMID:20414831] comment: Platelets are reportedly CCR1-positive, CCR2-negative, CCR3-positive, CCR4-positive, CCR5-negative, CCR6-negative, CCR7-negative, CCR8-negative, CCR9-negative, CCR10-negative, CD16-positive, CD23-positive, CD32-positive, CD40-positive, CD41-positive CD42-positive, CD61-positive, CD62P-positive, CD64-positive, CD89-positive, CD102-positive, CD147-positive (activated platelets), CD154-positive (activated platelets), CD162-positive, CD209, CD282-positive, CD284-positive, CD289-positive, CD181-negative, CD182-negative, CD183-negative, CD184-positive, CLEC2-positive, GPVI-positive, JAMC-positive, PAR1-positive, PAR2-negative, PAR3-positive, PAR4-positive, TSP1-positive, and TXA2R-positive. Platelets can reportedly produce CCL2, CCL3, CCL5, CCL7, CCL17, CD40L, CXCL1, CXCL4, CXCL4L1, CXCL5, CXCL7, CXCL8, CXCL12, EGF, factor V, factor VII, factor XI, factor XIII, bFGF, histamine, IGF-1, IL-1beta, PAI-1, PDGF, plasminogen, protein S, serotonin, TGF-beta, TFPI, VEGF, and vWF. subset: blood_and_immune_upper_slim subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "anucleate thrombocyte" EXACT [] synonym: "blood platelet" EXACT [] synonym: "enucleate thrombocyte" EXACT [] xref: BTO:0000132 xref: CALOHA:TS-0803 xref: FMA:62851 is_a: CL:0000081 ! blood cell is_a: CL:0000225 ! anucleate cell is_a: CL:0000458 ! serotonin secreting cell is_a: CL:0000763 {is_inferred="true"} ! myeloid cell relationship: RO:0000053 PATO:0001874 ! has characteristic discoid relationship: RO:0002202 CL:0000556 ! develops from megakaryocyte relationship: RO:0002216 GO:0007596 ! capable of part of blood coagulation property_value: RO:0002175 NCBITaxon:9606 property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0000233" xsd:string {name="platelet on CELLxGENE CellGuide"} property_value: terms:description "Platelets, also known as thrombocytes, are small, disc-shaped cell fragments devoid of a nucleus, yet remarkably intricate and multi-functional. They originate from the megakaryocytes in the bone marrow via a process called thrombopoiesis. Platelets are central to hemostasis, a process that prevents bleeding from broken or damaged blood vessels and facilitates wound healing. In their resting state, platelets are inactive but become quickly activated when an injury occurs.\nPlatelets function in the initiation and regulation of coagulation or clotting, which is a complex process involving several bioactive molecules. When a blood vessel is injured, the inner lining of the vessel, the endothelium, gets disrupted, exposing the underlying tissue matrix. This leads to platelet activation and adhesion to the injury site, initiating the clotting cascade. Platelets release granules packed with clotting factors, proteins, enzymes, and more platelets, which further propagates the clotting process. When activated, platelets also change their shape from discoid to a spherical form with protruding pseudopods that enables them to adhere more readily to the site of injury and mesh with one another to form a 'platelet plug'. \nAdditionally, platelets serve other physiological roles. They release growth factors enhancing tissue regeneration and wound healing. They also play a significant role in inflammation, innate immunity, and antimicrobial host defense, as they interact with leukocytes and may sequester microbes. Platelets are involved in maintaining the integrity of the blood vessels and angiogenesis, the formation of new blood vessels. Proper functioning of platelets is critical for maintaining homeostasis, while dysregulation can lead to conditions such as thrombosis or bleeding disorders.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1007/s10555-017-9677-x", xref="DOI:10.1016/j.blre.2014.10.003", xref="DOI:10.1038/s41569-018-0110-0", xref="DOI:10.3389/fimmu.2019.01731"} [Term] id: CL:0000234 name: phagocyte def: "Any cell capable of ingesting particulate matter via phagocytosis." [GOC:add, ISBN:0721601464] subset: cellxgene_subset subset: human_subset subset: mouse_subset xref: BTO:0001044 xref: FMA:83806 xref: MESH:D010586 xref: ZFA:0009140 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000219 ! motile cell is_a: CL:0000325 ! stuff accumulating cell intersection_of: CL:0000000 ! cell intersection_of: RO:0002215 GO:0006909 ! capable of phagocytosis relationship: RO:0002215 GO:0006909 ! capable of phagocytosis property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0000234" xsd:string {name="phagocyte on CELLxGENE CellGuide"} property_value: terms:description "Phagocytes are a heterogeneous group of white blood cells that have the capability to ingest, or ‘phagocytose’, foreign substances, pathogens, and cellular debris with high efficiency, thereby playing a vital role in the immune response. Phagocytes circulate throughout the body, patrolling and guarding against the invasion of pathogens. They are one among many types of cells that originate from hematopoietic stem cells in the bone marrow.\nUpon detection of an invading microorganism, phagocytes are mobilized by inflammatory mediators (such as bacterial proteins or complement proteins) to the infection site. They recognize surface molecules, specifically antigens, on harmful bacteria or other foreign substances with the help of opsonins, which are proteins that bind to the pathogen and make them more susceptible to phagocytosis. The process of phagocytosis involves the extension of the phagocyte's membrane around the microorganism, completely enclosing it within a microbicidal vacuole, the phagolysosome, which contains various microbicidal chemicals and digestive enzymes such as cathepsins, proteases, lysozymes, and lipases that may be employed to degrade the pathogen.\nPhagocytes are predominantly neutrophils or monocytes. Neutrophils are the most abundant type of phagocyte and are usually the first to arrive at the site of infection. Monocytes are derived from the bone marrow and can circulate to tissues and mature into local macrophages. Macrophages arrive later at sites of infection and are longer-lived than neutrophils. The process of phagocytosis must be tightly regulated to avoid host tissue damage.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:0.3389/fimmu.2020.01066", xref="DOI:10.1016/B978-0-08-046884-6.00607-2", xref="DOI:10.1016/B978-0-12-809633-8.90746-5", xref="DOI:10.1086/374747", xref="DOI:10.1182/blood-2007-12-077917"} [Term] id: CL:0000235 name: macrophage def: "A mononuclear phagocyte present in variety of tissues, typically differentiated from monocytes, capable of phagocytosing a variety of extracellular particulate material, including immune complexes, microorganisms, and dead cells." [GO_REF:0000031, GOC:add, GOC:tfm, PMID:16213494, PMID:1919437] comment: Morphology: Diameter 30_M-80 _M, abundant cytoplasm, low N/C ratio, eccentric nucleus. Irregular shape with pseudopods, highly adhesive. Contain vacuoles and phagosomes, may contain azurophilic granules; markers: Mouse & Human: CD68, in most cases CD11b. Mouse: in most cases F4/80+; role or process: immune, antigen presentation, & tissue remodelling; lineage: hematopoietic, myeloid. subset: blood_and_immune_upper_slim subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "histiocyte" EXACT [] xref: BTO:0000801 xref: CALOHA:TS-0587 xref: FMA:63261 xref: FMA:83585 xref: MESH:D008264 xref: ZFA:0009141 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000113 ! mononuclear phagocyte is_a: CL:0000145 ! professional antigen presenting cell is_a: CL:0000766 {is_inferred="true"} ! myeloid leukocyte intersection_of: CL:0000766 ! myeloid leukocyte intersection_of: RO:0002215 GO:0002504 ! capable of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II intersection_of: RO:0002215 GO:0006909 ! capable of phagocytosis intersection_of: RO:0002215 GO:0031268 ! capable of pseudopodium organization relationship: RO:0002202 CL:0000576 ! develops from monocyte relationship: RO:0002215 GO:0031268 ! capable of pseudopodium organization property_value: RO:0002175 NCBITaxon:9606 property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0000235" xsd:string {name="macrophage on CELLxGENE CellGuide"} property_value: terms:description "Macrophages are specialized white blood cells involved in immune responses, inflammation, and tissue repair. Tissue-resident macrophages can be self-renewing and arise from embryo-derived populations. Macrophages can also originate from circulating monocytes that differentiate into macrophages upon migration into body tissues. \nMacrophages are involved in the detection, phagocytosis, and destruction of bacteria and other pathogens. They are also responsible for engulfing and removing dead cells and debris. Macrophages are also one of the cells that present pathogenic antigens to T cells so that the pathogens may be recognized and killed, or so that an antibody response may be mounted. They can also secrete cytokines, chemokines, and enzymes that further orchestrate the immune response.\nTissue-resident macrophages are diverse and heterogenous, likely as a result of the signals received from the tissue environment. The functions of these macrophages are specific to each tissue and contribute to tissue homeostasis. Dysregulation of macrophage functioning may also contribute to the development of various disease processes, such as fibrosis, chronic inflammation, or cancer.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1016/j.immuni.2016.02.015", xref="DOI:10.1038/ni.2705", xref="DOI:10.1093/intimm/dxy054", xref="DOI:10.1146/annurev-immunol-032414-112220", xref="DOI:10.3389/fimmu.2021.708186"} [Term] id: CL:0000236 name: B cell def: "A lymphocyte of B lineage that is capable of B cell mediated immunity." [GO_REF:0000031, GOC:add, GOC:tfm, ISBN:0781735149] subset: blood_and_immune_upper_slim subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "B lymphocyte" EXACT [] synonym: "B-cell" EXACT [] synonym: "B-lymphocyte" EXACT [] xref: BTO:0000776 xref: CALOHA:TS-0068 xref: FMA:62869 xref: MESH:D001402 xref: VHOG:0001480 xref: ZFA:0009142 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000945 {is_inferred="true"} ! lymphocyte of B lineage intersection_of: CL:0000945 ! lymphocyte of B lineage intersection_of: RO:0002215 GO:0019724 ! capable of B cell mediated immunity relationship: RO:0002215 GO:0019724 ! capable of B cell mediated immunity property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0000237 name: keratinizing barrier epithelial cell subset: cellxgene_subset subset: human_subset subset: mouse_subset is_a: CL:0000240 ! stratified squamous epithelial cell is_a: CL:0000311 ! keratin accumulating cell is_a: CL:0002077 ! ecto-epithelial cell relationship: RO:0002202 CL:0000114 ! develops from surface ectodermal cell [Term] id: CL:0000238 name: non keratinizing barrier epithelial cell subset: human_subset subset: mouse_subset is_a: CL:0000240 ! stratified squamous epithelial cell [Term] id: CL:0000239 name: brush border epithelial cell def: "An epithelial cell characterized by the presence of a brush border on its apical surface, which increases the surface area for absorption." [] comment: All brush border cells are columnar-cuboidal. The formal logical definition of this term asserts this. Brush border epithelial cells are predominantly found lining the small intestine and the proximal tubules of the kidneys. subset: human_subset subset: mouse_subset xref: https://doi.org/10.1152/ajpgi.00005.2011 xref: PMID:25422372 xref: ZFA:0009143 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000075 ! columnar/cuboidal epithelial cell intersection_of: CL:0000066 ! epithelial cell intersection_of: BFO:0000051 GO:0005903 ! has part brush border relationship: BFO:0000051 GO:0005903 ! has part brush border [Term] id: CL:0000240 name: stratified squamous epithelial cell def: "A stratified epithelial cell that is part of squamous epithelium, characterized by multiple layers of cells. The basal layer is directly attached to the basement membrane and the apical layer consists of flattened squamous cells. This provides a protective barrier, commonly found in areas subject to abrasion, such as the skin, oral cavity, and esophagus." [PMID:30422572, Wikipedia:Epithelium, Wikipedia:Stratified_squamous_epithelium] subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset xref: ZFA:0009144 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000076 ! squamous epithelial cell is_a: CL:0000079 ! stratified epithelial cell intersection_of: CL:0000079 ! stratified epithelial cell intersection_of: BFO:0000050 UBERON:0006915 ! part of stratified squamous epithelium relationship: BFO:0000050 UBERON:0006915 ! part of stratified squamous epithelium property_value: RO:0002175 NCBITaxon:9606 property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0000240" xsd:string {name="stratified squamous epithelial cell on CELLxGENE CellGuide"} property_value: terms:description "Stratified squamous epithelial cells are a specific type of epithelial cell that form layers and have a flat shape. These cells are part of the outermost layer of the skin, called the epidermis, and are also found lining surfaces of the body that are subjected to physical or chemical wear and tear, such as the mouth, esophagus, and vagina. The primary role of these cells is to create a barrier that protects underlying tissues from dehydration, abrasion, and infection.\nThe stratified squamous epithelium is able to provide a strong, force-resistant barrier due to the stratified arrangement of the cells; it consists primarily of keratinocytes in various stages of differentiation: The basal layer contains cells that continuously divide and push older cells towards the surface. As the cells move up through the layers, they gradually flatten and become filled with a protein called keratin. In high-abrasion areas like the skin, the outer layers of these cells can become so filled with keratin that they die (they become 'keratinized'), providing an even more robust barrier; eventually, they are shed off in a process known as desquamation.\nIn addition to forming a protective barrier, stratified squamous epithelial cells also play a part in the immune response. They can recognize pathogens, and in response, release chemical signals that attract immune cells to the site of potential infection. Moreover, they also carry out a variety of interactions with the immune system to ensure that invading pathogens cannot penetrate into deeper layers of the body.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1007/s00281-018-0701-1", xref="DOI:10.1016/j.jdermsci.2004.05.004", xref="DOI:10.1016/j.jdermsci.2018.01.012", xref="DOI:10.1038/onc.2010.456"} [Term] id: CL:0000241 name: stratified cuboidal epithelial cell def: "A stratified epithelial cell that is part of cuboidal epithelium, characterized by multiple layers of cuboidal cells forming the apical layer. This provides a protective lining for ducts in large glands, such as sweat glands." [PMID:30422572, Wikipedia:Stratified_cuboidal_epithelium] subset: human_reference_atlas subset: human_subset subset: mouse_subset xref: ZFA:0009145 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000075 ! columnar/cuboidal epithelial cell is_a: CL:0000079 ! stratified epithelial cell intersection_of: CL:0000079 ! stratified epithelial cell intersection_of: BFO:0000050 UBERON:0010077 ! part of cuboidal epithelium relationship: BFO:0000050 UBERON:0010077 ! part of cuboidal epithelium property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/2d-ftu/liver-liver-lobule/v1.3/assets/2d-ftu-liver-liver-lobule.png" xsd:string {terms:licence="http://creativecommons.org/licenses/by/4.0/", xref="doi:10.48539/HBM889.CJPK.447"} property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0000242 name: Merkel cell def: "A specialized epithelial cell located in the skin epidermis and certain mucosal epithelia. It functions as a mechanoreceptor for light touch by forming synapse-like contacts with somatosensory afferent nerve endings, contributing to slowly adapting type I (SAI) tactile responses. Characterized by dense-core neuroendocrine granules, the Merkel cell exhibits both sensory and neuroendocrine properties, including regulated neurotransmitter release via SNARE complex-dependent mechanisms. Its development in mice depends on the transcription factor Atoh1." [MESH:D018862, PMID:19834574, PMID:2274847, PMID:24862916, PMID:30415995, Wikipedia:Merkel_cell] subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "MC" RELATED OMO:0003000 [PMID:24862916] synonym: "Merkel's cell" EXACT [] xref: FMA:70548 xref: ZFA:0009146 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000123 ! neuron associated cell (sensu Vertebrata) is_a: CL:0000710 ! neurecto-epithelial cell is_a: CL:1100001 ! secretory epithelial cell relationship: BFO:0000051 GO:0031201 ! has part SNARE complex relationship: RO:0002215 GO:0007269 ! capable of neurotransmitter secretion property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/2d-ftu/skin-epidermal-ridge/v1.2/assets/2d-ftu-skin-epidermal-ridge.png" xsd:string {terms:licence="http://creativecommons.org/licenses/by/4.0/", xref="doi:10.48539/HBM642.BMZS.772"} property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0000243 name: obsolete glial cell (sensu Vertebrata) def: "A non-neuronal cell of the nervous system. They not only provide physical support, but also respond to injury, regulate the ionic and chemical composition of the extracellular milieu. Form the myelin insulation of nervous pathways, guide neuronal migration during development, and exchange metabolites with neurons. Neuroglia have high-affinity transmitter uptake systems, voltage-dependent and transmitter-gated ion channels, and can release transmitters, but their role in signaling (as in many other functions) is unclear." [MESH:D009457] comment: This is a grouping class that is no longer needed or wanted. property_value: IAO:0000233 https://github.com/obophenotype/cell-ontology/issues/715 is_obsolete: true [Term] id: CL:0000244 name: transitional epithelial cell def: "A cell characteristically found lining hollow organs that are subject to great mechanical change due to contraction and distention; originally thought to represent a transition between stratified squamous and columnar epithelium." [GOC:tfm, ISBN:0721662544] subset: human_reference_atlas subset: human_subset subset: mouse_subset xref: FMA:66778 xref: ZFA:0009148 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000066 ! epithelial cell property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0000245 name: obsolete passage cell def: "Obsolete. Use PO:0000353 from Plant Ontology instead. Cell in exodermis or endodermis that remains thin walled when the associated cells develop thick secondary walls. Has casparian strip in endodermis." [ISBN:0471245208] is_obsolete: true replaced_by: PO:0000353 [Term] id: CL:0000246 name: Mauthner neuron subset: human_subset subset: mouse_subset xref: ZFA:0009149 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000099 ! interneuron [Term] id: CL:0000247 name: Rohon-Beard neuron def: "Type of neuron that is a primary mechanosensory cell, with peripheral neurites innervating the skin with free nerve endings." [VHOG:0001484] synonym: "RB neuron" RELATED [VHOG:0001484] synonym: "Rohon Beard cell" EXACT [VHOG:0001484] synonym: "Rohon-Beard cell" EXACT [] xref: AAO:0010316 xref: EFO:0003711 xref: VHOG:0001484 xref: ZFA:0009150 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000531 ! primary sensory neuron (sensu Teleostei) [Term] id: CL:0000248 name: obsolete microsporocyte def: "Obsolete. Use PO:0020047 from Plant Ontology instead. A diploid (2n) cell that undergoes meiosis and forms four haploid (1n) microspores; also called microspore mother cell and, in seed plants, pollen mother cell." [ISBN:0471245208] synonym: "pollen mother cell" EXACT [] synonym: "primary sporogenous cell" EXACT [] is_obsolete: true replaced_by: PO:0020047 [Term] id: CL:0000249 name: hatching gland cell subset: human_subset subset: mouse_subset xref: ZFA:0009151 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000151 ! secretory cell [Term] id: CL:0000250 name: obsolete megaspore def: "Obsolete. Use PO:0020019 from Plant Ontology instead. A haploid (1n) spore developing into a female gametophyte in heterosporous plants." [ISBN:0471245208] is_obsolete: true replaced_by: PO:0020019 [Term] id: CL:0000251 name: extramedullary cell subset: human_subset subset: mouse_subset xref: ZFA:0009152 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000101 ! sensory neuron [Term] id: CL:0000252 name: obsolete microspore def: "Obsolete. Use PO:0020048 from Plant Ontology instead. A haploid (1n) spore developing into a male gametophyte in heterosporous plants; the uninucleate pollen grain in seed plants." [ISBN:0471245208] is_obsolete: true replaced_by: PO:0020048 [Term] id: CL:0000253 name: eurydendroid cell subset: cellxgene_subset subset: human_subset subset: mouse_subset xref: ZFA:0009153 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000527 ! efferent neuron [Term] id: CL:0000254 name: obsolete egg cell def: "Obsolete. Use PO:0020094 from Plant Ontology instead. The female gamete of plants." [TAIR:lr] synonym: "female gametophyte egg cell" EXACT [] is_obsolete: true replaced_by: PO:0020094 [Term] id: CL:0000255 name: eukaryotic cell def: "Any cell that in taxon some Eukaryota." [FBC:Autogenerated] subset: human_subset subset: mouse_subset xref: MESH:D005057 is_a: CL:0000000 ! cell intersection_of: CL:0000000 ! cell intersection_of: RO:0002162 NCBITaxon:2759 ! in taxon Eukaryota disjoint_from: CL:0000520 ! prokaryotic cell relationship: RO:0002162 NCBITaxon:2759 ! in taxon Eukaryota property_value: skos:prefLabel "eukaryotic cell" xsd:string [Term] id: CL:0000256 name: uric acid accumulating cell subset: human_subset subset: mouse_subset is_a: CL:0000325 ! stuff accumulating cell [Term] id: CL:0000257 name: Eumycetozoan cell def: "Any cell that in taxon some Eumycetozoa." [FBC:Autogenerated] is_a: CL:0000255 ! eukaryotic cell intersection_of: CL:0000000 ! cell intersection_of: RO:0002162 NCBITaxon:142796 ! in taxon Eumycetozoa relationship: RO:0002162 NCBITaxon:142796 ! in taxon Eumycetozoa [Term] id: CL:0000258 name: obsolete fiber tracheid def: "Obsolete. Use PO:0000355 from Plant Ontology instead. A fiber like tracheid in the secondary xylem; commonly thick walled, with pointed ends and bordered pits that have lenticular to slit like apertures." [ISBN:0471245208] is_obsolete: true replaced_by: PO:0000355 [Term] id: CL:0000259 name: obsolete aggregate cell is_obsolete: true replaced_by: DDANAT:0000403 [Term] id: CL:0000260 name: obsolete mucilage cell def: "Obsolete. Use PO:0000373 from Plant Ontology instead. Cell containing mucilages or gums or similar carbohydrate material characterized by the property of swelling in water." [ISBN:0471245208] is_obsolete: true replaced_by: PO:0000373 [Term] id: CL:0000261 name: obsolete anterior cell comment: Obsoleted becuase this term has an overly general name, no definition, and by it's classification appears to refer to a very specific cell type in dictystelium. If needed, the term should be in DDANAT - probably as a subclass of http://purl.obolibrary.org/obo/DDANAT_0000002 is_obsolete: true consider: false consider: http://purl.obolibrary.org/obo/DDANAT_0000002 [Term] id: CL:0000262 name: obsolete guard mother cell def: "Obsolete. Use PO:0000351 from Plant Ontology instead. An epidermal cell that divides to produce the guard cells." [ISBN:0471245208] is_obsolete: true replaced_by: PO:0000351 [Term] id: CL:0000263 name: obsolete vegetative cell (sensu Mycetozoa) is_obsolete: true replaced_by: DDANAT:0000002 [Term] id: CL:0000264 name: obsolete phloem initial def: "Obsolete. Use PO:0000400 from Plant Ontology instead. A cambial cell on the phloem side of the cambial zone that is the source of one or more cells arising by periclinal divisions and differentiating into phloem elements with or without additional divisions in various planes." [ISBN:0471245208] synonym: "phloem mother cell" EXACT [] is_obsolete: true replaced_by: PO:0000400 [Term] id: CL:0000265 name: obsolete anterior like cell is_obsolete: true replaced_by: DDANAT:0000404 [Term] id: CL:0000266 name: obsolete meristemoid def: "Obsolete. Use PO:0004011 from Plant Ontology instead. A cell constituting an active locus of meristematic activity in a tissue composed of somewhat older, differentiating cells." [ISBN:0471245208] is_obsolete: true replaced_by: PO:0004011 [Term] id: CL:0000267 name: obsolete prespore cell is_obsolete: true replaced_by: DDANAT:0000405 [Term] id: CL:0000268 name: obsolete sieve element def: "Obsolete. Consult Plant Ontology instead. The cell in the phloem tissue concerned with mainly longitudinal conduction of food materials. Classified into sieve cell and sieve tube member." [ISBN:0471245208] is_obsolete: true [Term] id: CL:0000269 name: obsolete prestalk cell is_obsolete: true replaced_by: DDANAT:0000406 [Term] id: CL:0000270 name: obsolete subsidiary cell def: "Obsolete. Use PO:0000284 from Plant Ontology instead. An epidermal cell associated with a stoma and at least morphologically distinguishable from the epidermal cells composing the groundmass of the tissue." [ISBN:047124520] is_obsolete: true replaced_by: PO:0000284 [Term] id: CL:0000271 name: obsolete prestalk A cell is_obsolete: true replaced_by: DDANAT:0000408 [Term] id: CL:0000272 name: obsolete cambial initial def: "OBSOLETE, use term from Plant Ontology. A cell localized in the vascular cambium or phellogen. Its periclinal division can contribute cells either to the outside or to the inside of the axis; in vascular cambium, classified into fusiform initials (source of axial cells of xylem and phloem) and ray initials (source of the ray cells)." [ISBN:0471245208] comment: replaced_by PO:0000295 is_obsolete: true [Term] id: CL:0000273 name: obsolete prestalk AB cell is_obsolete: true replaced_by: DDANAT:0000410 [Term] id: CL:0000275 name: obsolete prestalk B cell is_obsolete: true replaced_by: DDANAT:0000409 [Term] id: CL:0000276 name: obsolete sclerenchyma cell def: "Obsolete. Use PO:0000077 from Plant Ontology instead. Cell variable in form and size, being more or less thick, often lignified, secondary walls. Belongs to the category of subcells and may or may not be devoid of protoplast at maturity." [ISBN:0471245208] is_obsolete: true replaced_by: PO:0000077 [Term] id: CL:0000277 name: obsolete prestalk I cell def: "OBSOLETE: Initial population of prestalk cells that activate the ecmA promoter at the mound stage and that presumably further differentiate into pstA and pstO cells." [DictyBase:DDB] comment: This cell type does not exist in Dictyostelium. it has been long deleted in their anatomy ontology. is_obsolete: true replaced_by: DDANAT:0000406 [Term] id: CL:0000278 name: obsolete central cell def: "Obsolete. Use PO:0020090 from Plant Ontology instead. OBSOLETED, use term from Plant Ontology. A cell containing the two polar nuclei which, after double fertilization, will develop into the endosperm." [TAIR:lr] is_obsolete: true replaced_by: PO:0020090 [Term] id: CL:0000279 name: obsolete prestalk 0 cell is_obsolete: true replaced_by: DDANAT:0000407 [Term] id: CL:0000280 name: obsolete generative cell def: "Obsolete. Use PO:0020097 from Plant Ontology instead. The cell that will give rise to the generative nuclei which will participate in fertilization." [TAIR:lr] is_obsolete: true replaced_by: PO:0020097 [Term] id: CL:0000281 name: obsolete pstAB/ALC is_obsolete: true replaced_by: DDANAT:0000411 [Term] id: CL:0000282 name: obsolete trichome def: "Obsolete. Use PO:0000282 from Plant Ontology instead. An outgrowth from the epidermis. Trichomes vary in size and complexity and include hairs, scales, and other structures and may be glandular. In Arabidopsis, patterning of trichome development is not random but does not appear to be lineage-based like stomata." [ISBN:0471245208, PMID:10938806] is_obsolete: true replaced_by: PO:0000282 [Term] id: CL:0000283 name: obsolete pstO/ALC is_obsolete: true replaced_by: DDANAT:0000412 [Term] id: CL:0000284 name: obsolete companion cell def: "Obsolete. Use PO:0000071 from Plant Ontology instead. A specialized parenchyma cell associated with a sieve-tube member in angiosperm phloem and arising from the same mother cell as the sieve-tube member." [ISBN:0879015322] is_obsolete: true replaced_by: PO:0000071 [Term] id: CL:0000285 name: obsolete stalk cell is_obsolete: true replaced_by: DDANAT:0000413 [Term] id: CL:0000286 name: hyphal cell def: "A cell of a filament of a fungal mycelium." [ISBN:08199377X] is_a: CL:0000521 ! fungal cell [Term] id: CL:0000287 name: eye photoreceptor cell def: "Any photoreceptor cell that is part of some eye." [FBC:Autogenerated] subset: cellxgene_subset subset: eye_upper_slim subset: human_reference_atlas subset: human_subset subset: mouse_subset xref: ZFA:0009154 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000006 ! neuronal receptor cell is_a: CL:0000210 ! photoreceptor cell intersection_of: CL:0000210 ! photoreceptor cell intersection_of: BFO:0000050 UBERON:0000970 ! part of eye relationship: BFO:0000050 UBERON:0000970 ! part of eye property_value: RO:0002175 NCBITaxon:9606 property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0000287" xsd:string {name="eye photoreceptor cell on CELLxGENE CellGuide"} property_value: skos:prefLabel "eye photoreceptor cell" xsd:string property_value: terms:description "Eye photoreceptor cells, also commonly known as photoreceptors, are specialized types of cells found in the retina, the light-sensitive layer at the back of the eye. They are integral to the complex process of vision, as they are directly involved in converting light into electrical signals. This process is known as phototransduction. There are two primary classes of photoreceptor cells; rods, which function mainly in dim light and provide black-and-white vision, and cones, which function in brighter light and allow for the perception of color.\nRods and cones carry out their roles through sophisticated biochemical reactions. The main component of these reactions is a protein called opsin, which binds to a small molecule known as retinal. In the presence of light, retinal changes its shape, leading to a series of chemical reactions that result in changes to the cell’s electrical potential, thus creating an electrical signal that travels to the optic nerve. Rod cells possess only one kind of opsin, called rhodopsin, which only allows them to distinguish between light and dark. Conversely, cone cells have three types of opsins, allowing for the differentiation of various colors.\nThe spatial distribution of these cell types throughout the retina also contributes to their function. Rod cells are more numerous and are distributed more at the periphery of the retina, contributing to peripheral and night vision. On the other hand, cone cells are concentrated in the macula, a tiny central region in the retina, and with the highest density in the fovea, a small pit in the macula. This distribution of cones lies at the base of fine detail and color vision in the central visual field. In summary, eye photoreceptor cells carry out the primary function of transforming light into visual signals, a role that is crucial for the overall process of vision.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1002/cne.902920402", xref="DOI:10.1038/eye.2016.107", xref="DOI:10.1098/rstb.2009.0051", xref="DOI:10.1146/annurev.biophys.31.082901.134348", xref="DOI:10.1186/gb-2005-6-3-213"} [Term] id: CL:0000288 name: obsolete synergid def: "Obsolete. Use PO:0000191 from Plant Ontology instead. A cell in the micropylar end of the embryo sac associated with the egg in the egg apparatus of angiosperms. Plays a vital role in fertilization." [ISBN:047125208] is_obsolete: true replaced_by: PO:0000191 [Term] id: CL:0000289 name: obsolete chemotactic amoeboid cell (sensu Mycetozoa) is_obsolete: true replaced_by: DDANAT:0000402 [Term] id: CL:0000290 name: obsolete xylem fiber cell def: "Obsolete. Use PO:0000274 from Plant Ontology instead. A fiber of the xylem tissue, Two types are recognized in the secondary xylem: fiber tracheids and libriform fibers." [ISBN:0471245208] is_obsolete: true replaced_by: PO:0000274 [Term] id: CL:0000291 name: obsolete spore (sensu Mycetozoa) is_obsolete: true replaced_by: DDANAT:0000414 [Term] id: CL:0000292 name: obsolete guard cell def: "Obsolete. Use PO:0000293 from Plant Ontology instead. One of a pair of cells flanking the stomatal pore and causing the opening and closing of the pore by changes in turgor." [ISBN:0471245208] synonym: "stomatal guard cell" EXACT [] is_obsolete: true replaced_by: PO:0000293 [Term] id: CL:0000293 name: obsolete structural cell def: "OBSOLETE. A cell whose primary function is to provide structural support, to provide strength and physical integrity to the organism." [TAIR:sr] comment: Unsustainable grouping term. property_value: IAO:0000233 https://github.com/obophenotype/cell-ontology/issues/3010 property_value: skos:prefLabel "structural cell" xsd:string is_obsolete: true [Term] id: CL:0000294 name: obsolete sieve cell def: "Obsolete. Consult Plant Ontology instead. A type of sieve element that has relatively undifferentiated sieve areas (with narrow pores), rather uniform in structure on all walls; that is, there are no sieve plates. Typical of gymnosperms and lower vascular plants." [ISBN:0471245208] is_obsolete: true [Term] id: CL:0000295 name: somatotropin secreting cell alt_id: CL:0000471 def: "A peptide hormone secreting cell that produces growth hormone, somatotropin." [GOC:tfm, SANBI:mhl] subset: human_subset subset: mouse_subset synonym: "growth hormone secreting cell" EXACT [] synonym: "somatotrophin secreting cell" EXACT [] xref: ZFA:0009155 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000167 ! peptide hormone secreting cell intersection_of: CL:0000151 ! secretory cell intersection_of: RO:0002215 GO:0030252 ! capable of growth hormone secretion relationship: RO:0002215 GO:0030252 ! capable of growth hormone secretion property_value: skos:prefLabel "somatotropin secreting cell" xsd:string [Term] id: CL:0000296 name: obsolete vegetative cell def: "Obsolete. Use PO:0020099 from Plant Ontology instead. Cell type formed after the first mitotic division of the microgametophye, The nucleus of this cell migrates to the tip of the pollen tube after germination and disintegrates when the pollen tube penetrates the nucellus." [ISBN:0140514031, TAIR:lr] is_obsolete: true replaced_by: PO:0020099 [Term] id: CL:0000297 name: obsolete socket cell def: "Obsolete. Use PO:0000115 from Plant Ontology instead. A cell that surrounds a trichome and provides support for the trichome." [PMID:10938806] is_obsolete: true replaced_by: PO:0000115 [Term] id: CL:0000298 name: obsolete xylem element def: "Obsolete. Use PO:0000273 from Plant Ontology instead. A cell composing the xylem." [ISBN:0471245208] is_obsolete: true replaced_by: PO:0000273 [Term] id: CL:0000299 name: obsolete trichoblast def: "OBSOLETED. Commonly used for a cell in root epidermis that gives rise to a root hair. The daughter cell produced by the asymmetric division of a root epidermal cell that gives rise to a root hair." [ISBN:0471245208] comment: Obsoleted. Use trichoblast from the plant ontology (PO:0000262). is_obsolete: true [Term] id: CL:0000300 name: gamete def: "A mature sexual reproductive cell having a single set of unpaired chromosomes." [GOC:tfm, ISBN:0721662544] subset: human_subset subset: mouse_subset synonym: "haploid germ cell" RELATED [] synonym: "haploid nucleated cell" EXACT [] xref: CALOHA:TS-0395 xref: FBbt:00005412 {sssom:mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"} xref: FMA:18649 xref: ZFA:0009156 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000413 ! haploid cell is_a: CL:0000586 {is_inferred="true"} ! germ cell intersection_of: CL:0000586 ! germ cell intersection_of: RO:0000053 PATO:0001375 ! has characteristic haploid intersection_of: RO:0002215 GO:0009566 ! capable of fertilization relationship: RO:0002215 GO:0009566 ! capable of fertilization property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0000300" xsd:string {name="gamete on CELLxGENE CellGuide"} property_value: terms:description "Gametes are reproductive cells essential for sexual reproduction in eukaryotic organisms, including humans, animals, and many plants. These cells are haploid, containing half the genome or only one set of chromosomes, which is a contrast to the diploid state (two sets of chromosomes) found in most cells in a multicellular organism. This reduction in genetic material is crucial since it allows for the re-establishment of the diploid number of chromosomes when two gametes merge to form a diploid zygote during fertilization.\nThere are two major types of gametes in animals: sperm cells in males and egg (or ova) in females. These gametes contribute equally to the genetic makeup of the offspring but are morphologically and functionally distinct. Sperm cells (or spermatozoa) are characterized by their motility, small size, and large quantities; they are produced continuously in vast numbers through a process called spermatogenesis in the male gonads or testes. Female gametes are much larger, fewer in numbers, and are not motile; they undergo a development process known as oogenesis, which takes place within the ovaries. The egg also contributes most of the cytoplasm and organelles (including mitochondria) to the zygote that are required for initial cell division stages after fertilization.\nGametes have a primary role in sexual reproduction and genetic variation, which aids in evolution. The formation of gametes involves a special type of cell division called meiosis that introduces genetic diversity via the process of recombination and independent assortment. Following the fusion of male and female gametes, the combination of paternal and maternal genetic material in the zygote allows for genetic recombination, which is a fundamental source of genetic variation and, thus, evolution. Therefore, gametes not only are critical to the inception of new individuals but also contribute to species survival and evolution.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1038/s41586-020-2347-0", xref="DOI:10.3389/fcell.2022.1040708", xref="https://www.ncbi.nlm.nih.gov/books/NBK10008/", xref="https://www.ncbi.nlm.nih.gov/books/NBK553142/"} [Term] id: CL:0000301 name: pole cell def: "A primordial germ cell of insects. Such cells form at the posterior pole of the early embryo." [doi:10.1017/CBO9780511818202.015] subset: human_subset subset: mouse_subset xref: FBbt:00000092 {sssom:mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"} is_a: CL:0000670 ! primordial germ cell [Term] id: CL:0000302 name: obsolete IgM B cell def: "OBSOLETE (was not defined before being made obsolete)." [] comment: Not a differentiation state per se; consider using 'B cell ; CL:0000236' or one of its children instead. is_obsolete: true [Term] id: CL:0000303 name: obsolete IgG B cell def: "OBSOLETE (was not defined before being made obsolete)." [] comment: Not a differentiation state per se, and IgG isotypes vary by species; consider using 'B cell ; CL:0000236' or one of its children instead. is_obsolete: true [Term] id: CL:0000304 name: obsolete IgA B cell def: "OBSOLETE (was not defined before being made obsolete)." [] comment: Not a differentiation state per se, and IgA isotypes vary by species. Consider using 'B cell ; CL:0000236' or one of its children instead. is_obsolete: true [Term] id: CL:0000305 name: obsolete IgE B cell def: "OBSOLETE (was not defined before being made obsolete)." [] comment: Not a differentiation state per se; consider using 'B cell ; CL:0000236' or one of its children instead. is_obsolete: true [Term] id: CL:0000306 name: crystallin accumulating cell subset: eye_upper_slim subset: human_subset subset: mouse_subset synonym: "lens cell" EXACT [] is_a: CL:0000325 ! stuff accumulating cell [Term] id: CL:0000307 name: tracheal epithelial cell alt_id: CL:1000474 def: "An epithelial cell found in the trachea." [GOC:tfm] comment: This class is for the vertebrate tracheal structure. For the analagous insect cell type, see 'respiratory tube epithelial cell' subset: human_subset subset: mouse_subset synonym: "tracheocyte" EXACT [] xref: FMA:74793 is_a: CL:0002202 {is_inferred="true"} ! epithelial cell of tracheobronchial tree intersection_of: CL:0000066 ! epithelial cell intersection_of: BFO:0000050 UBERON:0003126 ! part of trachea relationship: BFO:0000050 UBERON:0003126 ! part of trachea relationship: RO:0002202 CL:0000377 ! develops from tracheoblast [Term] id: CL:0000308 name: metal ion accumulating cell subset: human_subset subset: mouse_subset is_a: CL:0000325 ! stuff accumulating cell [Term] id: CL:0000309 name: copper accumulating cell subset: human_subset subset: mouse_subset synonym: "cuprophilic cell" EXACT [] is_a: CL:0000308 ! metal ion accumulating cell [Term] id: CL:0000310 name: iron accumulating cell subset: human_subset subset: mouse_subset is_a: CL:0000308 ! metal ion accumulating cell [Term] id: CL:0000311 name: keratin accumulating cell subset: human_subset subset: mouse_subset xref: ZFA:0009157 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000325 ! stuff accumulating cell [Term] id: CL:0000312 name: keratinocyte alt_id: CL:0002185 def: "An epithelial cell of stratified squamous tissues, including skin, oral mucosa (Hiroshima et al., 2011), and esophagus (Whelan et al., 2018), that produces keratin proteins and secretes antimicrobial peptides to form a resilient barrier against environmental damage, dehydration, pathogens, and microbial invasion. It undergoes successive stages of differentiation marked by changes in keratin expression, supporting tissue integrity, wound repair, and contributing to immune defense." [PMID:15749908, PMID:19256306, PMID:19727116, PMID:29713660, PMID:37873034] subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset xref: BTO:0000667 xref: CALOHA:TS-0500 xref: FMA:62879 xref: ZFA:0009158 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000237 {is_inferred="true"} ! keratinizing barrier epithelial cell relationship: RO:0002215 GO:0002775 ! capable of antimicrobial peptide production relationship: RO:0002215 GO:0002776 ! capable of antimicrobial peptide secretion relationship: RO:0002215 GO:0042060 ! capable of wound healing property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0000313 name: serous secreting cell def: "Columnar glandular cell with irregular nucleus, copious granular endoplasmic reticulum and supranuclear granules. Secretes a watery fluid containing proteins known as serous fluid." [GOC:tfm, ISBN:0517223651, ISBN:0721662544] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "serous cell" EXACT [] xref: BTO:0003687 xref: FMA:62511 is_a: CL:0000159 ! seromucus secreting cell [Term] id: CL:0000314 name: milk secreting cell subset: human_subset subset: mouse_subset is_a: CL:0000151 ! secretory cell [Term] id: CL:0000315 name: tear secreting cell def: "A cell secreting tears, the fluid secreted by the lacrimal glands. This fluid moistens the conjunctiva and cornea." [MESH:D013666] subset: human_subset subset: mouse_subset synonym: "tears secreting cell" EXACT [] is_a: CL:0000152 ! exocrine cell relationship: BFO:0000050 UBERON:0001817 ! part of lacrimal gland [Term] id: CL:0000316 name: obsolete ray initial def: "Obsolete. Use PO:0000082 from Plant Ontology instead. A meristemic ray cell in the vascular cambium that gives rise to ray cells of the secondary xylem and secondary phloem." [ISBN:0471245208] is_obsolete: true replaced_by: PO:0000082 [Term] id: CL:0000317 name: sebocyte def: "An epithelial cell that is part of a sebaceous gland. This cell produces and secretes sebum, an oily, lipid-rich substance, through holocrine secretion where the entire cell ruptures to release its contents." [MESH:D012629, PMID:19944183] subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "sebum secreting cell" EXACT [] is_a: CL:0000150 ! glandular secretory epithelial cell is_a: CL:0000152 ! exocrine cell is_a: CL:0000362 ! epidermal cell is_a: CL:0002308 ! epithelial cell of skin gland is_a: CL:2000021 ! sebaceous gland cell intersection_of: CL:0000066 ! epithelial cell intersection_of: BFO:0000050 UBERON:0001821 ! part of sebaceous gland property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/2d-ftu/skin-hair-follicle/v1.0/assets/2d-ftu-skin-hair-follicle.png" xsd:string {terms:licence="http://creativecommons.org/licenses/by/4.0/", xref="doi:10.48539/HBM853.HLFH.534"} property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0000318 name: sweat secreting cell def: "A cell secreting sweat, the fluid excreted by the sweat glands of mammals. It consists of water containing sodium chloride, phosphate, urea, ammonia, and other waste products." [MESH:D013542] subset: human_subset subset: mouse_subset is_a: CL:0000150 ! glandular secretory epithelial cell [Term] id: CL:0000319 name: mucus secreting cell def: "Any cell that is capable of some mucus secretion." [FBC:Autogenerated] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "mucous cell" EXACT [] xref: BTO:0003689 xref: ZFA:0009159 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000159 ! seromucus secreting cell intersection_of: CL:0000000 ! cell intersection_of: RO:0002215 GO:0070254 ! capable of mucus secretion relationship: RO:0002215 GO:0070254 ! capable of mucus secretion [Term] id: CL:0000320 name: obsolete megasporocyte def: "Obsolete. Use PO:0000431 from Plant Ontology instead. A diploid (2n) cell that undergoes meiosis and produces four haploid (1n) megaspores; also called megaspore mother cell." [ISBN:0471245208] synonym: "archesporial cell" EXACT [] synonym: "megaspore mother cell" EXACT [] is_obsolete: true replaced_by: PO:0000431 [Term] id: CL:0000321 name: obsolete seminal fluid secreting cell property_value: IAO:0000233 https://github.com/obophenotype/cell-ontology/issues/1149 is_obsolete: true replaced_by: CL:0000151 consider: CL:1001597 [Term] id: CL:0000322 name: pulmonary alveolar epithelial cell def: "An epithelial cell that lines the peripheral gas exchange region of the lungs of air-breathing vertebrates." [GOC:tfm, PMID:20054144, PMID:29463737] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "alveolar epithelial cell" EXACT [] synonym: "alveolus of lung epithelial cell" EXACT [] synonym: "epithelial cell of alveolus of lung" EXACT [] synonym: "pneumocyte" EXACT [PMID:32491474] synonym: "pneumonocyte" EXACT [] xref: BTO:0000395 xref: CALOHA:TS-2168 xref: FMA:62499 xref: MESH:D056809 is_a: CL:0000082 ! epithelial cell of lung intersection_of: CL:0000066 ! epithelial cell intersection_of: BFO:0000050 UBERON:0004821 ! part of pulmonary alveolus epithelium relationship: BFO:0000050 UBERON:0004821 ! part of pulmonary alveolus epithelium property_value: terms:contributor https://orcid.org/0000-0001-6677-8489 property_value: terms:date "2024-09-02T08:27:21Z" xsd:dateTime [Term] id: CL:0000323 name: lysozyme secreting cell subset: human_subset subset: mouse_subset is_a: CL:0000154 ! protein secreting cell [Term] id: CL:0000324 name: metanephric mesenchyme stem cell subset: cellxgene_subset subset: human_subset subset: mouse_subset is_a: BFO:0000002 is_a: CL:0000134 ! mesenchymal stem cell relationship: RO:0002202 CL:0000222 ! develops from mesodermal cell [Term] id: CL:0000325 name: stuff accumulating cell def: "A cell that is specialised to accumulate a particular substance(s)." [FB:ma] subset: human_subset subset: mouse_subset subset: ubprop:upper_level is_a: CL:0000000 ! cell property_value: skos:prefLabel "stuff accumulating cell" xsd:string [Term] id: CL:0000326 name: glycogen accumulating cell subset: human_subset subset: mouse_subset is_a: CL:0000325 ! stuff accumulating cell [Term] id: CL:0000327 name: extracellular matrix secreting cell subset: cellxgene_subset subset: human_subset subset: mouse_subset xref: ZFA:0009162 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000499 ! stromal cell property_value: skos:prefLabel "extracellular matrix secreting cell" xsd:string [Term] id: CL:0000329 name: oxygen accumulating cell def: "Any cell that is capable of some oxygen transport." [FBC:Autogenerated] subset: human_subset subset: mouse_subset xref: ZFA:0009164 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000000 ! cell intersection_of: CL:0000000 ! cell intersection_of: RO:0002215 GO:0015671 ! capable of oxygen transport relationship: RO:0002215 GO:0015671 ! capable of oxygen transport property_value: skos:prefLabel "oxygen accumulating cell" xsd:string [Term] id: CL:0000330 name: obsolete collenchymal cell def: "Obsolete. Use PO:0000075 from Plant Ontology instead. An elongated living cell with unevenly thickened nonlignified primary walls." [ISBN:0471245208] is_obsolete: true replaced_by: PO:0000075 [Term] id: CL:0000331 name: obsolete tracheid def: "Obsolete. Use PO:0000301 from Plant Ontology instead. A tracheary element of the xylem that has no perforations, as contrasted with a vessel member. May occur in primary and in secondary xylem. May have any kind of secondary wall thickening found in tracheary elements." [ISBN:0471245208] is_obsolete: true replaced_by: PO:0000301 [Term] id: CL:0000332 name: obsolete atrichoblast def: "OBSOLETE, use term from Plant Ontology. A cell formed after asymmetric division of root epidermal cell that does not give rise to a root hair." [ISBN:0387987819] synonym: "non-hair cell" RELATED [] is_obsolete: true replaced_by: PO:0020090 [Term] id: CL:0000333 name: migratory neural crest cell def: "A cell derived from the specialized ectoderm flanking each side of the embryonic neural plate, which after the closure of the neural tube, forms masses of cells that migrate out from the dorsal aspect of the neural tube to spread throughout the body." [doi:10.1016/j.stem.2015.02.017] subset: human_subset subset: mouse_subset xref: FMA:86667 xref: ZFA:0007086 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000219 ! motile cell is_a: CL:0011012 ! neural crest cell is_a: CL:0011026 ! progenitor cell relationship: RO:0002202 CL:0007004 ! develops from premigratory neural crest cell property_value: skos:prefLabel "migratory neural crest cell" xsd:string [Term] id: CL:0000334 name: vegetative cell (sensu Fungi) synonym: "yeast-form" RELATED [] xref: BTO:0002307 xref: FAO:0000032 is_a: CL:0000521 ! fungal cell [Term] id: CL:0000335 name: mesenchyme condensation cell def: "A mesenchymal cell in embryonic development found in a contracting mass and that gives rise to osteoprogenitors." [GOC:tfm, PMID:5025404] subset: cellxgene_subset subset: human_subset subset: mouse_subset xref: ZFA:0009166 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0008019 ! mesenchymal cell property_value: skos:prefLabel "mesenchyme condensation cell" xsd:string [Term] id: CL:0000336 name: adrenal medulla chromaffin cell alt_id: CL:1000422 def: "A cell found within the adrenal medulla that secrete biogenic amine hormones upon stimulation." [GOC:tfm, http://www.britannica.com/EBchecked/topic/6405/adrenal-gland] subset: human_subset subset: mouse_subset synonym: "medullary chromaffin cell of adrenal gland" EXACT [FMA:69262] xref: FMA:69262 xref: ZFA:0009167 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000457 ! biogenic amine secreting cell is_a: CL:1000426 ! chromaffin cell of adrenal gland intersection_of: CL:0000166 ! chromaffin cell intersection_of: BFO:0000050 UBERON:0001236 ! part of adrenal medulla relationship: BFO:0000050 UBERON:0001236 ! part of adrenal medulla relationship: RO:0002202 CL:0000011 ! develops from migratory trunk neural crest cell [Term] id: CL:0000338 name: neuroblast (sensu Nematoda and Protostomia) def: "A neural precursor of the central nervous system." [PMID:1295739] subset: cellxgene_subset synonym: "neuroblast" BROAD [] xref: FBbt:00005146 {sssom:mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"} is_a: CL:0000047 ! neural stem cell relationship: RO:0002162 NCBITaxon:33317 ! in taxon Protostomia [Term] id: CL:0000339 name: glioblast (sensu Vertebrata) def: "An early neural cell developing from the early ependymal cell of the neural tube." [GOC:tfm, ISBN:0618947256] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "spongioblast" EXACT [] xref: FMA:70564 xref: ZFA:0009169 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000030 ! glioblast is_a: CL:0000123 ! neuron associated cell (sensu Vertebrata) [Term] id: CL:0000340 name: glioblast (sensu Nematoda and Protostomia) def: "A precursor of the central nervous system that gives rise to glial cells only." [doi:10.1002/glia.21162] xref: FBbt:00005145 {sssom:mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"} is_a: CL:0000030 ! glioblast is_a: CL:0000130 ! neuron associated cell (sensu Nematoda and Protostomia) [Term] id: CL:0000341 name: pigment cell (sensu Nematoda and Protostomia) is_a: CL:0000147 ! pigment cell property_value: RO:0002161 NCBITaxon:33511 [Term] id: CL:0000342 name: pigment cell (sensu Vertebrata) def: "Any animal cell containing pigment granules." [GOC:tfm, ISBN:0721662544] subset: human_subset subset: mouse_subset xref: ZFA:0009170 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000147 ! pigment cell is_a: CL:0000255 ! eukaryotic cell relationship: RO:0002162 NCBITaxon:7742 ! in taxon Vertebrata [Term] id: CL:0000343 name: visual pigment cell (sensu Vertebrata) def: "A pigment cell that is capable of detecting light stimulus that is involved in visual perception." [GOC:tfm] subset: human_subset subset: mouse_subset xref: FMA:63846 xref: ZFA:0009171 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000149 ! visual pigment cell is_a: CL:0000342 {is_inferred="true"} ! pigment cell (sensu Vertebrata) intersection_of: CL:0000342 ! pigment cell (sensu Vertebrata) intersection_of: RO:0002215 GO:0050908 ! capable of detection of light stimulus involved in visual perception relationship: RO:0002215 GO:0050908 ! capable of detection of light stimulus involved in visual perception [Term] id: CL:0000344 name: obsolete non-visual cell (sensu Vertebrata) is_obsolete: true [Term] id: CL:0000345 name: dental papilla cell def: "A mesenchymal cell that is part of a small mass of condensed mesenchyme in the enamel organ; it differentiates into the dentin and dental pulp." [GOC:tfm, ISBN:0721662544] comment: Merge with odontoblast? subset: human_subset subset: mouse_subset xref: ZFA:0009173 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: BFO:0000002 is_a: CL:0000255 ! eukaryotic cell is_a: CL:0008019 ! mesenchymal cell relationship: BFO:0000050 UBERON:0001763 ! part of odontogenic papilla relationship: RO:0002202 CL:0000008 ! develops from migratory cranial neural crest cell [Term] id: CL:0000346 name: hair follicle dermal papilla cell def: "A specialized fibroblast that resides in the dermal papilla located at the bottom of hair follicles. This cell orchestrates reciprocal epithelial-mesenchymal signaling essential for hair follicle morphogenesis and cycling, regulating matrix cell proliferation and differentiation to control hair shaft size, shape, and growth. The dermal papilla cell is replenished each hair cycle from bipotent hair follicle dermal stem cells in the dermal sheath that simultaneously self-renew and contribute progeny to the papilla, particularly during anagen." [PMID:28418596, PMID:39798934, PMID:40867641] comment: The dermal papilla contains functionally heterogeneous Sox2-positive subpopulations that serve as a niche for multipotent stem cells. These cells exhibit progenitor properties, generate skin-derived precursors (SKPs), and can differentiate into adipogenic and osteogenic lineages. {xref="PMID:21444748"} subset: human_subset subset: mouse_subset synonym: "hair follicle DPC" RELATED OMO:0003000 [PMID:39798934] is_a: CL:1000302 ! fibroblast of papillary layer of dermis intersection_of: CL:0000057 ! fibroblast intersection_of: BFO:0000050 UBERON:0000412 ! part of dermal papilla relationship: BFO:0000050 UBERON:0000412 ! part of dermal papilla relationship: RO:0002215 GO:0042634 ! capable of regulation of hair cycle relationship: RO:0002215 GO:0060638 ! capable of mesenchymal-epithelial cell signaling relationship: RO:0002596 GO:0031069 ! capable of regulating hair follicle morphogenesis [Term] id: CL:0000347 name: scleral cell def: "A cell of the sclera of the eye." [GOC:add] subset: eye_upper_slim subset: human_subset subset: mouse_subset xref: ZFA:0009174 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: BFO:0000002 is_a: CL:0000255 ! eukaryotic cell intersection_of: CL:0000000 ! cell intersection_of: BFO:0000050 UBERON:0001773 ! part of sclera relationship: BFO:0000050 UBERON:0001773 ! part of sclera relationship: RO:0002202 CL:0000008 ! develops from migratory cranial neural crest cell property_value: skos:prefLabel "scleral cell" xsd:string [Term] id: CL:0000348 name: choroidal cell of the eye def: "A cell that is part of optic choroid." [GOC:add] subset: eye_upper_slim subset: human_subset subset: mouse_subset xref: ZFA:0009175 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: BFO:0000002 is_a: CL:0000255 ! eukaryotic cell intersection_of: CL:0000000 ! cell intersection_of: BFO:0000050 UBERON:0001776 ! part of optic choroid relationship: BFO:0000050 UBERON:0001776 ! part of optic choroid relationship: RO:0002202 CL:0000008 ! develops from migratory cranial neural crest cell [Term] id: CL:0000349 name: extraembryonic cell def: "Any cell that is part of some extraembryonic structure." [FBC:Autogenerated] subset: cellxgene_subset subset: general_cell_types_upper_slim subset: human_subset subset: mouse_subset xref: ZFA:0009176 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000255 ! eukaryotic cell intersection_of: CL:0000000 ! cell intersection_of: BFO:0000050 UBERON:0000478 ! part of extraembryonic structure relationship: BFO:0000050 UBERON:0000478 ! part of extraembryonic structure [Term] id: CL:0000350 name: amnioserosal cell def: "Any extraembryonic cell that is part of some amnioserosa." [FBC:Autogenerated] is_a: CL:0000349 ! extraembryonic cell intersection_of: CL:0000349 ! extraembryonic cell intersection_of: BFO:0000050 UBERON:0010302 ! part of amnioserosa relationship: BFO:0000050 UBERON:0010302 ! part of amnioserosa [Term] id: CL:0000351 name: trophoblast cell def: "An extraembryonic cell that develops from a trophectodermal cell. This cell is found in the outer layer of the blastocyst and can invade other structures in the uterus once the blastocyst implants into the uterine wall. A trophoblast cell is involved in the implantation of the embryo into the uterine wall, placental formation, remodelling of maternal vasculature in the uterus, nutrient and gas exchange, hormone production, and immune modulation to support fetal development." [doi:10.1007/978-3-030-84725-8, GOC:tfm, MESH:D014327, PMID:37630754] subset: human_subset subset: mouse_subset synonym: "trophoblastic cell" EXACT [doi:10.1007/978-3-030-84725-8] xref: FMA:83028 is_a: BFO:0000002 is_a: CL:0000349 {is_inferred="true"} ! extraembryonic cell relationship: RO:0002202 CL:1000274 ! develops from trophectodermal cell property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0000351" xsd:string {name="trophoblast cell on CELLxGENE CellGuide"} property_value: terms:description "Trophoblast cells, originating from the blastocyst's outer layer, are highly specialized and pivotal for embryo development. Their crucial roles include facilitating implantation and contributing to the formation of the placenta, an essential organ for fetal nutrition, gas exchange, and waste removal during pregnancy.\nThese cells play a crucial role in implantation by adhering to the uterus lining. Post-implantation, some trophoblast cells differentiate, forming syncytiotrophoblasts. These multi-nucleated cells absorb nutrients, release waste, and secrete hormones, including human chorionic gonadotropin (hCG), sustaining pregnancy.\nTrophoblast cells also play a crucial role in immune tolerance, preventing the maternal immune system from treating the fetus as foreign. This balance is vital for a healthy pregnancy. Dysfunctional trophoblast cells may lead to complications like miscarriages or preeclampsia, emphasizing their importance in both embryology and reproductive medicine.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1016/j.jri.2023.103811", xref="DOI:10.1530/JOE-17-0402", xref="https://www.ncbi.nlm.nih.gov/books/NBK53245"} [Term] id: CL:0000352 name: epiblast cell def: "A cell of the outer layer of a blastula that gives rise to the ectoderm after gastrulation." [GOC:tfm, ISBN:0618947256] subset: human_subset subset: mouse_subset is_a: CL:0000052 ! totipotent stem cell property_value: skos:prefLabel "epiblast cell" xsd:string [Term] id: CL:0000353 name: blastoderm cell def: "An undifferentiated cell produced by early cleavages of the fertilized egg (zygote)." [MESH:D001756] subset: human_subset subset: mouse_subset synonym: "blastomere" EXACT [] xref: BTO:0001473 xref: FMA:72551 xref: ZFA:0009177 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000007 ! early embryonic cell (metazoa) [Term] id: CL:0000354 name: blastemal cell subset: human_subset subset: mouse_subset synonym: "blastema cell" EXACT [] xref: ncithesaurus:Blastemal_Cell xref: ZFA:0009178 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000048 ! multi fate stem cell [Term] id: CL:0000355 name: multi-potent skeletal muscle stem cell def: "A multifate stem cell found in skeletal muscle than can differentiate into many different cell types, including muscle. Distinct cell type from satellite cell." [PMID:18282570] comment: Multi-potency demonstrated ex vivo. At the time of writing, it is unclear whether the endogenous population differentiates into multiple cell types in vivo. subset: human_subset subset: mouse_subset xref: FMA:86767 xref: ZFA:0009179 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000048 {is_inferred="true"} ! multi fate stem cell is_a: CL:0000188 ! cell of skeletal muscle intersection_of: CL:0000048 ! multi fate stem cell intersection_of: BFO:0000050 UBERON:0001134 ! part of skeletal muscle tissue property_value: skos:prefLabel "multi-potent skeletal muscle stem cell" xsd:string [Term] id: CL:0000356 name: hair matrix stem cell subset: human_subset subset: mouse_subset is_a: CL:0000035 ! single fate stem cell [Term] id: CL:0000357 name: stratified epithelial stem cell subset: human_subset subset: mouse_subset xref: ZFA:0009180 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000036 ! epithelial fate stem cell [Term] id: CL:0000358 name: sphincter associated smooth muscle cell def: "A smooth muscle cell that is part of a sphincter. A sphincter is a typically circular muscle that normally maintains constriction of a natural body passage or orifice and which relaxes as required by normal physiological functioning." [GOC:cjm] subset: human_subset subset: mouse_subset is_a: CL:0000192 {is_inferred="true"} ! smooth muscle cell intersection_of: CL:0000192 ! smooth muscle cell intersection_of: BFO:0000050 UBERON:0004590 ! part of sphincter muscle relationship: BFO:0000050 UBERON:0004590 ! part of sphincter muscle property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0000358" xsd:string {name="sphincter associated smooth muscle cell on CELLxGENE CellGuide"} property_value: terms:description "Smooth muscle cells, as a broader category, are non-striated, involuntary muscle cells that usually exhibit contractions and dilation to facilitate numerous physiological functions. Sphincter associated smooth muscle cells are a specific type of smooth muscle cell that are primarily associated with the functioning of various anatomical sphincters in the human body.\nThe traits that distinguishes sphincter associated smooth muscle cells from other smooth muscle cells are their location and specialized function in sphincter mechanisms. Sphincter associated smooth muscle cells play a pivotal role in regulating the opening and closure of the bodily sphincters. These sphincters can be found at multiple locations within the body including the gastrointestinal tract (namely the esophagus, stomach, small intestine, and rectum), the urinary tract, and the circulatory system. Upon receiving signals from the autonomous nervous system, these cells contract or relax to modulate the aperture of sphincters, thus controlling the movement of substances through them. Due to their precise and vital functional role, any dysfunction or dysregulation in these cells can lead to serious medical conditions, such as gastroesophageal reflux or urinary incontinence.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="https://www.ncbi.nlm.nih.gov/books/NBK482438/", xref="https://www.ncbi.nlm.nih.gov/books/NBK532857/", xref="https://www.ncbi.nlm.nih.gov/books/NBK557452/"} [Term] id: CL:0000359 name: vascular associated smooth muscle cell def: "A smooth muscle cell associated with the vasculature." [GOC:dsd, GOC:tfm] subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "vascular smooth muscle cell" EXACT [] synonym: "VSMC" EXACT [] xref: ZFA:0009181 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000192 {is_inferred="true"} ! smooth muscle cell is_a: CL:4033054 ! perivascular cell intersection_of: CL:0000192 ! smooth muscle cell intersection_of: BFO:0000050 UBERON:0002049 ! part of vasculature relationship: BFO:0000050 UBERON:0002049 ! part of vasculature property_value: RO:0002175 NCBITaxon:9606 property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0000359" xsd:string {name="vascular associated smooth muscle cell on CELLxGENE CellGuide"} property_value: terms:description "Vascular associated smooth muscle cells (VSMCs) are specialized cells that constitute a major component of the blood vessel wall in the circulatory system. They derive their name from the predominantly smooth appearance under microscopic examination, as opposed to the striated appearance of cardiac and skeletal muscles. \nA principal function of VSMCs is to regulate vascular tone, which directly dictates blood pressure and blood flow distribution across various body parts. This is achieved through coordinated contraction and relaxation of the muscles in response to a variety of extracellular signals. When a blood vessel is exposed to stimuli like pressure or injury, VSMCs contract, resulting in vasoconstriction and ultimately, an increase in blood pressure. Conversely, in response to vasodilators, these cells relax, leading to vasodilation and a consequent decrease in blood pressure.\nVSMCs are also involved in vascular remodeling, a process where blood vessels adapt their structure to long-term changes in hemodynamic conditions or disease states. In diseases like atherosclerosis and hypertension, an aberrant proliferative and synthetic phenotype of VSMCs contributes to the formation of plaques, leading to vessel hardening or even occlusion. Recent research has further implicated these cells in immune responses, recognizing their function in leukocyte recruitment and inflammation, factors that are largely instrumental in vascular pathologies.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1093/cvr/cvs135", xref="DOI:10.1093/cvr/cvy023", xref="DOI:10.1161/ATVBAHA.118.311229", xref="DOI:10.3389/fimmu.2020.599415", xref="DOI:10.3390/ijms20225694"} [Term] id: CL:0000360 name: morula cell def: "A cell of the early embryo at the developmental stage in which the blastomeres, resulting from repeated mitotic divisions of the fertilized ovum (zygote), form a compact cell mass." [MESH:D009028] subset: human_subset subset: mouse_subset is_a: CL:0000007 ! early embryonic cell (metazoa) is_a: CL:0000255 ! eukaryotic cell relationship: BFO:0000050 UBERON:0000085 ! part of morula [Term] id: CL:0000361 name: gastrula cell def: "A cell of the embryo in the early stage following the blastula, characterized by morphogenetic cell movements, cell differentiation, and the formation of the three germ layers." [MESH:D005775] subset: human_subset subset: mouse_subset xref: ZFA:0009182 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000007 ! early embryonic cell (metazoa) is_a: CL:0000255 ! eukaryotic cell relationship: BFO:0000050 UBERON:0004734 ! part of gastrula [Term] id: CL:0000362 name: epidermal cell alt_id: CL:1000396 def: "An epithelial cell of the integument (the outer layer of an organism)." [Flybase:dsj, MA:ma] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "cell of epidermis" EXACT [FMA:62411] synonym: "epithelial cell of skin" NARROW [FMA:62411] xref: BTO:0001470 xref: CALOHA:TS-0283 xref: FMA:62411 xref: MESH:D000078404 xref: ZFA:0009183 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0002159 ! general ecto-epithelial cell intersection_of: CL:0000066 ! epithelial cell intersection_of: BFO:0000050 UBERON:0007376 ! part of outer epithelium relationship: BFO:0000050 UBERON:0007376 ! part of outer epithelium property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0000362" xsd:string {name="epidermal cell on CELLxGENE CellGuide"} property_value: terms:description "Epidermal cells constitute the outermost layer of the skin in animals and have a multifaceted role in maintaining the body's overall homeostasis. They originate from the ectoderm and form the epidermis, a stratified squamous epithelium that mostly consists of keratinocytes in various stages of differentiation. The primary role of these cells is to act as a physical barrier, shielding the internal organs, tissues, and system from dehydration, infection, and other external influences such as UV radiation. The thickness and stratification of the epidermis vary with its location in the body, depending on the specific demand for protective function.\nOne notable characteristic of epidermal cells is their continuous cycle of renewal. The cells are produced in the deepest layer of the epidermis, known as the basal or germinative layer, where they undergo cell division. As new cells form, they gradually push the older cells towards the skin surface. While ascending, these cells undergo a process known as keratinization, where they become filled with keratin, a protein that provides strength and rigidity. By the time they reach the surface, they are essentially dead and filled with keratin, forming a tough, resistant layer that is regularly shed and replaced by newer cells beneath. This entire process, from cell generation to shedding, usually takes around a month.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1016/j.tcb.2018.05.002", xref="DOI:10.1146/annurev.cellbio.22.010305.104357", xref="https://www.ncbi.nlm.nih.gov/books/NBK513299/#:~:text=The%20stratum%20corneum%20is%20the%20outermost%20layer%20of%20the%20epidermis,potential%20and%20undergo%20programmed%20destruction."} [Term] id: CL:0000363 name: obsolete axial cell def: "Obsolete. Use PO:0000081 from Plant Ontology instead. OBSOLETE, use term from the Plant Ontology. A secondary vascular cell that develops from the fusiform cambial initials and oriented with their longest diameter parallel with the main axis of stem or root. These cells make up the axial system, also known as vertical or longitudinal system." [ISBN:0471245208] is_obsolete: true replaced_by: PO:0000081 [Term] id: CL:0000364 name: obsolete ray cell def: "Obsolete. Consult Plant Ontology. A cell that develops from the ray initial and composes all rays (panels of tissue variable in height and width, formed by the ray initials in the vascular cambium and extending radially in the secondary xylem and secondary phloem) in the secondary vascular tissues." [ISBN:0471245208] is_obsolete: true [Term] id: CL:0000365 name: animal zygote def: "Diploid cell produced by the fusion of sperm cell nucleus and egg cell." [ISBN:0471245208] subset: human_subset subset: mouse_subset synonym: "zygote" BROAD [] xref: BTO:0000854 xref: EHDAA2:0004546 xref: FMA:72395 is_a: CL:0000007 ! early embryonic cell (metazoa) is_a: CL:0000255 ! eukaryotic cell is_a: CL:0010017 ! zygote intersection_of: CL:0010017 ! zygote intersection_of: RO:0002162 NCBITaxon:33208 ! in taxon Metazoa relationship: RO:0002162 NCBITaxon:33208 ! in taxon Metazoa property_value: skos:prefLabel "animal zygote" xsd:string [Term] id: CL:0000366 name: obsolete sperm cell (sensu Viridiplantae) def: "Obsolete. Use PO:0000084 from Plant Ontology instead. Male gamete, part of male germ unit." [ISBN:0471245208] synonym: "gametophyte sperm cell" RELATED [] synonym: "male gametophyte sperm cell" RELATED [] synonym: "pollen germ cell" RELATED [] is_obsolete: true replaced_by: PO:0000084 [Term] id: CL:0000367 name: sheath cell (sensu Nematoda) subset: human_subset subset: mouse_subset synonym: "glial cell (sensu Nematoda)" RELATED [] is_a: CL:0000619 ! supporting cell (sensu Nematoda) [Term] id: CL:0000368 name: obsolete myrosin cell def: "Obsolete. Use PO:0000352 from Plant Ontology instead. Cell containing glucosinolates ('mustard oil glucosides') and myrosinases, enzymes hydrolyzing the glucosinolates. Occurs in eleven dicotyledon families, the two largest of which are the Brassicaceae and Euphorbiaceae." [ISBN:0471245208] is_obsolete: true replaced_by: PO:0000352 [Term] id: CL:0000370 name: obsolete transfer cell def: "Obsolete. Use PO:0000078 from Plant Ontology instead. Parenchyma cell with the wall ingrowth (or invaginations) that increase the surface of the plasmalemma. Appears to be specialized for short-distance transfer of solutes." [ISBN:0471245208] synonym: "intermediary cell" RELATED [] is_obsolete: true replaced_by: PO:0000078 [Term] id: CL:0000371 name: protoplast def: "The cell protoplasm after removal of the cell wall." [ISBN:08199377X] xref: MESH:D011523 is_a: CL:0000578 ! experimentally modified cell in vitro property_value: RO:0002161 NCBITaxon:33208 [Term] id: CL:0000372 name: tormogen cell def: "An epidermal cell that is part of a cell cluster organ of the insect integument (such as a sensillum) and that secretes a cuticular specialization that forms a socket around the base of a cuticular specialization produced by a trichogen cell." [ISBN:978-0801481253] synonym: "socket cell" BROAD [ISBN:978-0801481253] xref: FBbt:00005171 {sssom:mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"} is_a: CL:0000463 ! epidermal cell (sensu Arthropoda) [Term] id: CL:0000373 name: histoblast def: "A progenitor cell found in the larval epidermis of insects and that gives rise to the adult abdominal epidermis." [doi:10.1016/j.cub.2022.01.045] xref: FBbt:00001789 {sssom:mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"} is_a: CL:0011026 ! progenitor cell relationship: RO:0002162 NCBITaxon:50557 ! in taxon Insecta [Term] id: CL:0000374 name: trichogen cell def: "An epidermal cell that is part of a cell cluster organ of the insect integument (such as a sensillum) and that secretes a cuticular specialization, often in the form of a hair, bristle, peg or scale. The base of this specialization is often surrounded by a socket produced by a closely associated tormogen cell." [ISBN:978-0801481253] synonym: "hair cell" BROAD [] xref: BTO:0004744 xref: FBbt:00005169 {sssom:mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"} is_a: CL:0000463 ! epidermal cell (sensu Arthropoda) [Term] id: CL:0000375 name: obsolete osteoprogenitor cell xref: BTO:0002051 is_obsolete: true replaced_by: CL:0007010 [Term] id: CL:0000376 name: humidity receptor cell subset: human_subset subset: mouse_subset is_a: CL:0000006 ! neuronal receptor cell [Term] id: CL:0000377 name: tracheoblast subset: human_subset subset: mouse_subset is_a: CL:0000069 ! branched duct epithelial cell [Term] id: CL:0000378 name: supporting cell (sensu Nematoda and Protostomia) subset: human_subset subset: mouse_subset synonym: "support cell (sensu Nematoda and Protostomia)" EXACT [] is_a: CL:0000630 ! supporting cell [Term] id: CL:0000379 name: sensory processing neuron subset: human_subset subset: mouse_subset xref: ZFA:0009185 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:2000029 ! central nervous system neuron relationship: RO:0002215 GO:0050893 ! capable of sensory processing [Term] id: CL:0000380 name: thecogen cell def: "The support cell that makes the thecogen dendritic cap - a cuticle-like matrix around the tip of the eo-dendrite and which encloses the soma of the eo-neuron." [Fbbt:00005173] subset: human_subset subset: mouse_subset synonym: "fly sheath cell" EXACT [] xref: FBbt:00005173 {sssom:mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"} is_a: CL:0000378 ! supporting cell (sensu Nematoda and Protostomia) [Term] id: CL:0000381 name: obsolete neurosecretory neuron comment: 'neuroendocrine cell' (which has exact synonym "neurosecretory cell") and 'neurosecretory neuron' may all refer to the same cell type. property_value: IAO:0000233 https://github.com/obophenotype/cell-ontology/issues/1784 is_obsolete: true replaced_by: CL:0000165 [Term] id: CL:0000382 name: scolopale cell def: "A cell that is part of a scolopidium and surrounds the dendrite of a scolopidial neuron." [doi:10.1016/B978-012369493-5.50012-2, doi:10.1017/CBO9780511818202.024] synonym: "scolopidial sheath cell" EXACT [ISBN:978-087969828-7] xref: FBbt:00005219 {sssom:mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"} is_a: CL:0000255 ! eukaryotic cell is_a: CL:0000378 ! supporting cell (sensu Nematoda and Protostomia) relationship: BFO:0000050 UBERON:0001038 ! part of chordotonal organ [Term] id: CL:0000383 name: nephrogenic mesenchyme stem cell subset: human_subset subset: mouse_subset xref: ZFA:0009187 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000134 ! mesenchymal stem cell is_a: CL:0011026 ! progenitor cell relationship: RO:0002202 CL:0000134 ! develops from mesenchymal stem cell [Term] id: CL:0000384 name: ligament cell subset: human_subset subset: mouse_subset xref: ZFA:0009188 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000630 ! supporting cell [Term] id: CL:0000385 name: prohemocyte (sensu Nematoda and Protostomia) def: "A precursor of mature hemocytes." [doi:10.1016/B978-012369493-5.50008-0] xref: FBbt:00005062 {sssom:mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"} is_a: CL:0008001 ! hematopoietic precursor cell property_value: RO:0002161 NCBITaxon:33511 [Term] id: CL:0000386 name: obsolete attachment cell comment: The obsoleted term is redundant property_value: IAO:0000233 https://github.com/obophenotype/cell-ontology/issues/3016 is_obsolete: true [Term] id: CL:0000387 name: hemocyte (sensu Arthropoda) def: "A blood cell of the circulatory system of arthropods." [doi:10.1016/B978-012369493-5.50008-0] xref: FBbt:00005063 {sssom:mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"} is_a: BFO:0000002 is_a: CL:0000255 ! eukaryotic cell is_a: CL:0000390 ! blood cell (sensu Nematoda and Protostomia) relationship: RO:0002162 NCBITaxon:6656 ! in taxon Arthropoda relationship: RO:0002202 CL:0000385 ! develops from prohemocyte (sensu Nematoda and Protostomia) [Term] id: CL:0000388 name: tendon cell def: "An elongated fibroblast that is part of a tendon. Its cytoplasm is stretched between the collagen fibres of the tendon, and it possesses a central nucleus with a prominent nucleolus. Tendon cell has a well-developed rough endoplasmic reticulum, and it is responsible for the synthesis and turnover of tendon fibres and ground substance." [GOC:NV, GOC:tfm, PMID:37894875, PMID:957445] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "muscle attachment cell" EXACT [] synonym: "tenocyte" RELATED [] xref: ZFA:0009189 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:1000307 ! fibroblast of dense regular elastic tissue intersection_of: CL:0000057 ! fibroblast intersection_of: BFO:0000050 UBERON:0000043 ! part of tendon relationship: BFO:0000050 UBERON:0000043 ! part of tendon [Term] id: CL:0000389 name: socket cell (sensu Nematoda) subset: human_subset subset: mouse_subset is_a: CL:0000619 ! supporting cell (sensu Nematoda) is_a: CL:0000658 ! cuticle secreting cell [Term] id: CL:0000390 name: blood cell (sensu Nematoda and Protostomia) is_a: CL:0000081 ! blood cell property_value: RO:0002161 NCBITaxon:33511 [Term] id: CL:0000391 name: obsolete podocyte (sensu Diptera) comment: Obsoleted as podocytes are not a distinct cell type from plasmatocytes. property_value: IAO:0000233 https://github.com/obophenotype/cell-ontology/issues/1949 is_obsolete: true replaced_by: CL:0000394 [Term] id: CL:0000392 name: crystal cell def: "A hemocyte that synthesizes and secretes melanins as part of the antimicrobial immune response. It is characterized morphologically by crystal inclusions of phenoloxidases in its cytoplasm, hence its name." [doi:10.1016/B978-012369493-5.50008-0] is_a: CL:0000387 ! hemocyte (sensu Arthropoda) relationship: RO:0002202 CL:0000395 ! develops from procrystal cell [Term] id: CL:0000393 name: electrically responsive cell def: "A cell whose function is determined by its response to an electric signal." [FB:ma] subset: human_subset subset: mouse_subset xref: ZFA:0009190 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000211 ! electrically active cell property_value: skos:prefLabel "electrically responsive cell" xsd:string [Term] id: CL:0000394 name: plasmatocyte def: "A phagocytic hemocyte, responsible for the engulfment of small particles, microbes, and apoptotic tissue debris. It may also secretes antimicrobial peptides and contribute to the production and secretion of proteins of the hemolymph." [https://doi.org/10.1016/B978-012369493-5.50008-0] subset: cellxgene_subset synonym: "macrophage" RELATED [] xref: FBbt:00001685 {sssom:mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"} is_a: CL:0000387 ! hemocyte (sensu Arthropoda) relationship: RO:0002215 GO:0035010 ! capable of encapsulation of foreign target [Term] id: CL:0000395 name: procrystal cell def: "A precursor of mature crystal cells." [doi:10.1016/B978-012369493-5.50008-0] xref: FBbt:00001689 {sssom:mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"} is_a: CL:0000385 ! prohemocyte (sensu Nematoda and Protostomia) [Term] id: CL:0000396 name: lamellocyte def: "A hemocyte found in immuno-stimulated larvae." [doi:10.1016/B978-012369493-5.50008-0] xref: FBbt:00001687 {sssom:mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"} is_a: CL:0000387 ! hemocyte (sensu Arthropoda) [Term] id: CL:0000397 name: ganglion interneuron def: "Any interneuron that has its soma located in some ganglion." [FBC:Autogenerated] subset: cellxgene_subset subset: human_subset subset: mouse_subset is_a: CL:0000099 {is_inferred="true"} ! interneuron intersection_of: CL:0000099 ! interneuron intersection_of: RO:0002100 UBERON:0000045 ! has soma location ganglion relationship: RO:0002100 UBERON:0000045 ! has soma location ganglion property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0000397" xsd:string {name="ganglion interneuron on CELLxGENE CellGuide"} property_value: terms:description "Ganglion interneurons, sometimes classified under 'relay neurons,' are complex cellular structures prominently found in the nervous system across various organisms. These cells serve as intermediaries or connectors, conducting impulses between afferent (or sensory) neurons and efferent (or motor) neurons within the body. They have specialized roles in sensory-motor integration within the nervous system and play a pivotal part in defining the complexity and precision of the nervous system.\nThese highly specialized neurons are predominantly located in the spinal cord and brain, particularly abundant in the gray matter of these regions, forming complex neural networks. The increased presence of glial cells around interneurons acts as an insulator enhancing the speed of impulse transmission. Ganglion interneurons receive informational input through dendrites from sensory neurons; this information is then converted into electrical impulses, which are processed and transmitted to other neurons or effectors, such as muscles or glands, through axons.\nFurthermore, these ganglion interneurons have significant roles in the formulation and execution of motor reflexes and serve as integral components of reflex arcs. They also participate in the modulation and filtration of relevant sensory information, ensuring that signals reaching the late-stage processing units (like the brain) are refined and critical to the organism's survival. Consequently, these neurons significantly influence the organism's behavior based on the incoming sensory information. Overall, they are responsible for creating connections amongst various neural circuits, making them pivotal in producing integrated responses and maintaining the proper functioning of the nervous system.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1038/nn.2707", xref="DOI:10.1111/j.1748-1716.1962.tb02497.x", xref="DOI:10.1152/jn.1992.68.4.1384", xref="DOI:10.1371/journal.pcbi.1002626", xref="DOI:10.1523/JNEUROSCI.5570-03.2004"} [Term] id: CL:0000398 name: obsolete polygonal cell comment: Obsoleted as this is actually the same thing as prohemocytes. property_value: IAO:0000233 https://github.com/obophenotype/cell-ontology/issues/1949 is_obsolete: true replaced_by: CL:0000385 [Term] id: CL:0000399 name: obsolete phloem element def: "Obsolete. Consult Plant Ontology instead. OBSOLETED, not defined prior to obsoletion." [GOC:tfm] is_obsolete: true [Term] id: CL:0000400 name: obsolete pavement cell def: "Obsolete. Use PO:0000332 from Plant Ontology instead. An epidermal cell with a characteristic convoluted anticlinal cell wall that gives a jigsaw like appearance to the lamina." [ISBN:087694289] is_obsolete: true replaced_by: PO:0000332 [Term] id: CL:0000401 name: obsolete macrophage (sensu Diptera) comment: Obsoleted as plasmatocytes are the macrophages (phagocytic cells) of Diptera. property_value: IAO:0000233 https://github.com/obophenotype/cell-ontology/issues/1949 is_obsolete: true replaced_by: CL:0000394 [Term] id: CL:0000402 name: obsolete CNS interneuron def: "OBSOLETE. An interneuron that has its cell body in a central nervous system." [doi:10.1016/B978-0-12-817424-1.00001-X] comment: Interneurons are commonly described as being only found in the central nervous system. However, in CL we define 'interneuron' more broadly as any neuron that is neither a motor neuron nor a sensory neuron, regardless of its location, so we need this term to refer strictly to interneurons of the central nervous system. subset: human_reference_atlas property_value: IAO:0000233 https://github.com/obophenotype/cell-ontology/issues/2869 property_value: RO:0002175 NCBITaxon:9606 is_obsolete: true replaced_by: CL:0000099 [Term] id: CL:0000404 name: electrically signaling cell def: "A cell that initiates an electrical signal and passes that signal to another cell." [FB:ma] subset: human_subset subset: mouse_subset xref: ZFA:0009193 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000211 ! electrically active cell property_value: skos:prefLabel "electrically signaling cell" xsd:string [Term] id: CL:0000405 name: obsolete neuroepidermoblast comment: Obsoleted as the term seems completely unused in the literature. property_value: IAO:0000233 https://github.com/FlyBase/drosophila-anatomy-developmental-ontology/issues/1621 is_obsolete: true [Term] id: CL:0000406 name: CNS short range interneuron subset: human_subset subset: mouse_subset xref: ZFA:0009194 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000099 ! interneuron [Term] id: CL:0000407 name: scolopidial ligament cell def: "A cell that anchors the cell body of a scolopidial neuron to the integument." [doi:10.1016/B978-0-12-408088-1.00002-6, doi:10.1023/a\:1018564904170] xref: FBbt:00005221 {sssom:mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"} is_a: CL:0000255 ! eukaryotic cell is_a: CL:0000378 ! supporting cell (sensu Nematoda and Protostomia) relationship: BFO:0000050 UBERON:0001038 ! part of chordotonal organ [Term] id: CL:0000408 name: male gamete def: "Any male germ cell that has characteristic some haploid and is capable of some fertilization." [FBC:Autogenerated] subset: human_subset subset: mouse_subset xref: BTO:0001277 xref: CALOHA:TS-0949 is_a: CL:0000015 {is_inferred="true"} ! male germ cell is_a: CL:0000300 {is_inferred="true"} ! gamete intersection_of: CL:0000015 ! male germ cell intersection_of: RO:0000053 PATO:0001375 ! has characteristic haploid intersection_of: RO:0002215 GO:0009566 ! capable of fertilization property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0000408" xsd:string {name="male gamete on CELLxGENE CellGuide"} property_value: terms:description "The male gamete, also known as a sperm cell, is a highly specialized cell type critical to sexual reproduction. Sperm are produced during a process called spermatogenesis within the male reproductive organ, specifically the testes. They are haploid cells, carrying the genetic material from the male parent, and fuse with the ovum, the female gamete, to form a diploid zygote during fertilization, thereby initiating gestation and the development of a new organism.\nThe male gamete is distinguished by its morphology, notably its elongated shape which is geared towards locomotion. One of the primary characteristics of a male gamete is its flagellum, or tail, which propels the cell towards the female gamete. It additionally contains an elongated head region housing the nucleus, where the genetic material is stored. The anterior section of the head, the acrosome, releases enzymes essential for penetrating the protective layers of the ovum during the fertilization process.\nThe function of male gametes does not cease upon fertilization. In addition to delivering the paternal set of chromosomes, fusion of the sperm cell with the ovum causes an increase in cytosolic Ca2+ which then activates the female egg cell to undergo the so-called cortical reaction during which the egg’s zona pellucida is changed so fusion with additional sperm is prevented. The Ca2+ signal also initiates the development of the zygote and eventual formation of an embryo. Male gametes also contribute towards forming the placenta, which supplies nutrients and removes waste products during gestation.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1016/j.semcdb.2016.04.009", xref="DOI:10.1242/dev.202046", xref="https://www.ncbi.nlm.nih.gov/books/NBK26843/", xref="https://www.ncbi.nlm.nih.gov/books/NBK553142/"} [Term] id: CL:0000409 name: obsolete scolopidial sheath cell comment: Obsoleted as this refers to the same cell type as 'scolopale cell'. is_obsolete: true replaced_by: CL:0000382 [Term] id: CL:0000410 name: CNS long range interneuron subset: human_subset subset: mouse_subset xref: ZFA:0009195 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000099 ! interneuron [Term] id: CL:0000411 name: Caenorhabditis hypodermal cell def: "An epithelial cell of the hypodermis of Caenorhabditis." [GOC:tfm, http://www.wormatlas.org/hermaphrodite/hypodermis/mainframe.htm] comment: This term was originally added to CL for parity with the Worm anatomy ontology, which is dedicated to C elegans. It is not clear if it makes sense to try and generalize the concept and include in CL, and this term may be obsoleted in future. Note there is no similarity to the hypodermis in vertebrates. synonym: "roundworm hypodermal cell" BROAD [] xref: WBbt:0007846 xref: ZFA:0009196 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000066 ! epithelial cell is_a: CL:0000228 ! multinucleate cell relationship: RO:0002162 NCBITaxon:6237 ! in taxon Caenorhabditis [Term] id: CL:0000412 name: polyploid cell def: "A cell that contains more than two haploid sets of chromosomes." [FB:ma, https://bio.libretexts.org/Bookshelves/Introductory_and_General_Biology/Biology_(Kimball)/07%3A_Cell_Division/7.04%3A_Polyploidy, PMID:32646579] subset: human_subset subset: mouse_subset is_a: CL:0000000 ! cell intersection_of: CL:0000000 ! cell intersection_of: RO:0000053 PATO:0001377 ! has characteristic polyploid relationship: RO:0000053 PATO:0001377 ! has characteristic polyploid [Term] id: CL:0000413 name: haploid cell def: "A cell whose nucleus contains a single haploid genome." [FB:ma, GOC:tfm] subset: human_subset subset: mouse_subset is_a: CL:0000000 ! cell intersection_of: CL:0000000 ! cell intersection_of: RO:0000053 PATO:0001375 ! has characteristic haploid relationship: RO:0000053 PATO:0001375 ! has characteristic haploid [Term] id: CL:0000414 name: obsolete cell by ploidy def: "OBSOLETE: A classification of cells by the number of haploid genome equivalents of their nucleus or nuclei." [FB:ma, GOC:tfm] comment: This term was made obsolete because there is no difference in meaning between it and 'cell', as any cell with chromosomes can be classified by its ploidy. If you have used this term in annotation, please replace it with cell (CL:0000000), native cell (CL:0000003), eukaryotic cell (CL:0000255) or cell in vitro (CL:0001034) as appropriate. is_obsolete: true consider: CL:0000000 consider: CL:0000003 consider: CL:0000255 consider: CL:0001034 [Term] id: CL:0000415 name: diploid cell def: "A cell whose nucleus has two haploid genomes." [FB:ma] subset: human_subset subset: mouse_subset xref: FMA:72300 is_a: CL:0000000 ! cell [Term] id: CL:0000416 name: polytene cell subset: human_subset subset: mouse_subset is_a: CL:0000412 ! polyploid cell [Term] id: CL:0000417 name: endopolyploid cell subset: human_subset subset: mouse_subset is_a: CL:0000412 ! polyploid cell [Term] id: CL:0000418 name: arcade cell def: "An epithelial cell found in C. elegans that firmly hold the outer body wall and the lips to the inner cylinder of the pharynx in a manner that keeps these organs from breaking apart, while still giving each organ freedom of movement during feeding." [GOC:tfm, http://www.wormatlas.org/ver1/handbook/hypodermis/hypsupportother.htm#arcadecells] xref: WBbt:0005793 is_a: CL:0000066 ! epithelial cell relationship: RO:0002162 NCBITaxon:6237 ! in taxon Caenorhabditis [Term] id: CL:0000419 name: seam cell def: "An epithelial fate stem cell found in flatworms." [GOC:tfm, http://www.wormatlas.org/hermaphrodite/seam%20cells/mainframe.htm] subset: human_subset subset: mouse_subset xref: BTO:0003039 is_a: CL:0000036 ! epithelial fate stem cell [Term] id: CL:0000420 name: syncytial epithelial cell def: "An epithelial cell that forms a syncytium, which is a multinucleated cell resulting from the fusion of multiple cells." [] subset: human_subset subset: mouse_subset xref: Wikipedia:Syncytium is_a: CL:0000066 ! epithelial cell is_a: CL:4052002 ! syncytial cell [Term] id: CL:0000421 name: coelomocyte def: "A free floating cell, including amebocytes and eleocytes, in the coelom of certain animals, especially annelids." [GOC:tfm, ISBN:0721662544] xref: BTO:0002856 xref: WBbt:0005751 is_a: CL:0000080 ! circulating cell is_a: CL:0000519 ! phagocyte (sensu Nematoda and Protostomia) [Term] id: CL:0000422 name: mitogenic signaling cell def: "A cell whose primary function is to cause growth by stimulating cell division in its immediate cellular environment." [FB:ma] subset: human_subset subset: mouse_subset is_a: CL:0000000 ! cell [Term] id: CL:0000423 name: tip cell subset: cellxgene_subset subset: human_subset subset: mouse_subset is_a: CL:0000422 ! mitogenic signaling cell [Term] id: CL:0000424 name: excretory cell def: "A cell involved in the elimination of metabolic and foreign toxins, and in maintaining the ionic, acid-base and water balance of biological fluids." [GOC:tfm, PMID:19783135] subset: human_subset subset: mouse_subset xref: WBbt:0005812 is_a: CL:0000000 ! cell [Term] id: CL:0000425 name: pore cell def: "Forms the terminal part of the cuticle-lined excretory duct of C. elegans." [JB:jb] subset: human_subset subset: mouse_subset is_a: CL:0000658 ! cuticle secreting cell [Term] id: CL:0000426 name: obsolete scaffold cell comment: This is a cell used in tissue engineering and is out of scope for CL. property_value: IAO:0000233 https://github.com/obophenotype/cell-ontology/issues/708 is_obsolete: true [Term] id: CL:0000427 name: GLR cell def: "A scaffolding cell type found in C. elegans, this cell plays a supportive role to the muscle arms. May also have an endocrine role." [GOC:tfm, http://wormatlas.psc.edu/hermaphrodite/muscleGLR/mainframe.htm] subset: human_subset subset: mouse_subset is_a: CL:0002320 ! connective tissue cell [Term] id: CL:0000428 name: yolk cell subset: human_subset subset: mouse_subset xref: ZFA:0000084 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000325 ! stuff accumulating cell is_a: CL:0000349 ! extraembryonic cell [Term] id: CL:0000429 name: imaginal disc cell def: "A columnar epithelial cell that is part of an insect imaginal disc." [doi:10.1007/s00412-016-0595-4] comment: This term does not encompass all the cell types that may be found in an epithelial disc (such as the peripodial or adepithelial cells), only the cells that form the disc epithelium proper. xref: FBbt:00007108 {sssom:mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"} is_a: CL:0000146 ! simple columnar epithelial cell relationship: BFO:0000050 UBERON:0000939 ! part of imaginal disc [Term] id: CL:0000430 name: xanthophore cell def: "A pigment cell derived from the neural crest. Contains cartenoid pigments in structures called pterinosomes or xanthosomes. This gives an appearance ranging from a golden yellow to orange and red." [SANBI:mhl] subset: human_subset subset: mouse_subset synonym: "xanthophore" RELATED [] xref: ZFA:0009198 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: BFO:0000002 is_a: CL:0000147 ! pigment cell is_a: CL:0000255 ! eukaryotic cell relationship: RO:0002202 CL:0005002 ! develops from xanthoblast [Term] id: CL:0000431 name: iridophore def: "A pigment cell derived from the neural crest. The cell contains flat light-reflecting platelets, probably of guanine, in stacks called reflecting platelets or iridisomes. The color-generating components produce a silver, gold, or iridescent color." [SANBI:mhl] subset: human_subset subset: mouse_subset synonym: "guanophore" RELATED [] xref: ZFA:0009199 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: BFO:0000002 is_a: CL:0000147 ! pigment cell is_a: CL:0000255 ! eukaryotic cell relationship: RO:0002202 CL:0005001 ! develops from iridoblast [Term] id: CL:0000432 name: reticular cell def: "A fibroblast that synthesizes collagen and uses it to produce reticular fibers, thus providing structural support. Reticular cells are found in many organs, including the spleen, lymph nodes and kidneys. Subtypes of reticular cells include epithelial, mesenchymal, and fibroblastic reticular cells. Fibroblastic reticular cells are involved in directing B cells and T cells to specific regions within a tissue, whereas epithelial and mesenchymal reticular cells are associated with certain areas of the brain." [GOC:tfm, http://en.wikipedia.org/wiki/Reticular_cell, ISBN:0517223651] subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "reticulum cell" EXACT [] xref: FMA:62877 xref: ZFA:0009200 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000057 ! fibroblast property_value: RO:0002175 NCBITaxon:9606 property_value: seeAlso "https://github.com/obophenotype/cell-ontology/issues/1472" xsd:string [Term] id: CL:0000433 name: obsolete functional megaspore def: "Obsolete. Use PO:0000244 from Plant Ontology instead. In monosporic and bisporic megasporogenesis: the megaspore(s) that will undergo megagametogenesis." [TAIR:lr] is_obsolete: true replaced_by: PO:0000244 [Term] id: CL:0000434 name: eccrine cell def: "A secretory cell that discharges its product without loss of cytoplasm." [ISBN:0198547684] subset: human_reference_atlas subset: human_subset subset: mouse_subset is_a: CL:1100001 ! secretory epithelial cell property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0000435 name: alkali secreting cell subset: human_subset subset: mouse_subset xref: ZFA:0009201 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000151 ! secretory cell [Term] id: CL:0000436 name: vaginal lubricant secreting cell subset: human_subset subset: mouse_subset is_a: CL:0000151 ! secretory cell is_a: CL:0000255 ! eukaryotic cell relationship: BFO:0000050 UBERON:0000996 ! part of vagina [Term] id: CL:0000437 name: gonadtroph def: "A rounded cell that is usually situated next to sinusoids; secretes follicular stimulating hormone (FSH) and luteinizing hormone (LH)." [GOC:tfm, http://en.wikipedia.org/wiki/Gonadotroph, ISBN:0517223651] subset: human_subset subset: mouse_subset synonym: "delta basophil" EXACT [] synonym: "follicle stimulating hormone secreting cell" EXACT [] synonym: "gonadotrope" EXACT [] synonym: "gonadotrope cell" EXACT [] synonym: "gonadotroph" EXACT [] synonym: "gonadotropic cell" EXACT [] synonym: "pituitary delta cell" EXACT [] xref: BTO:0002482 xref: FMA:83100 xref: ZFA:0009202 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000438 ! luteinizing hormone secreting cell is_a: CL:0000639 ! basophil cell of pars distalis of adenohypophysis [Term] id: CL:0000438 name: luteinizing hormone secreting cell def: "A peptide hormone secreting cell pituitary that produces luteinizing hormone." [GOC:tfm] subset: human_subset subset: mouse_subset xref: ZFA:0009203 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000151 ! secretory cell intersection_of: CL:0000151 ! secretory cell intersection_of: RO:0002215 GO:0032275 ! capable of luteinizing hormone secretion relationship: RO:0002215 GO:0032275 ! capable of luteinizing hormone secretion property_value: skos:prefLabel "luteinizing hormone secreting cell" xsd:string [Term] id: CL:0000439 name: prolactin secreting cell def: "A peptide hormone cell that secretes prolactin." [GOC:tfm, SANBI:mhl] subset: human_subset subset: mouse_subset xref: ZFA:0009204 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000154 ! protein secreting cell is_a: CL:0000167 ! peptide hormone secreting cell intersection_of: CL:0000151 ! secretory cell intersection_of: RO:0002215 GO:0070459 ! capable of prolactin secretion relationship: RO:0002215 GO:0070459 ! capable of prolactin secretion property_value: skos:prefLabel "prolactin secreting cell" xsd:string [Term] id: CL:0000440 name: melanocyte stimulating hormone secreting cell def: "A cell of the intermediate pituitary that produces melanocyte stimulating hormone." [SANBI:mhl] subset: human_subset subset: mouse_subset synonym: "melanotrope" EXACT [] synonym: "melanotroph" EXACT [] xref: BTO:0002277 xref: ZFA:0009205 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000167 ! peptide hormone secreting cell intersection_of: CL:0000151 ! secretory cell intersection_of: RO:0002215 GO:0036160 ! capable of melanocyte-stimulating hormone secretion relationship: RO:0002215 GO:0036160 ! capable of melanocyte-stimulating hormone secretion property_value: skos:prefLabel "melanocyte stimulating hormone secreting cell" xsd:string [Term] id: CL:0000441 name: follicle stem cell (sensu Arthropoda) def: "A stem cell that gives rise to the follicle cells that surround the oocyte in female arthropods." [doi:10.1016/B978-012369493-5.50005-5, doi:10.1038/s41467-020-19361-0, doi:10.1242/dev.121.11.3797] synonym: "somatic stem cell" BROAD [doi:10.1016/j.devcel.2005.08.012] xref: FBbt:00004903 {sssom:mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"} is_a: CL:0000036 ! epithelial fate stem cell relationship: RO:0002162 NCBITaxon:6656 {IAO:0000233="https://github.com/obophenotype/cell-ontology/issues/1943"} ! in taxon Arthropoda [Term] id: CL:0000442 name: follicular dendritic cell def: "A cell with extensive dendritic processes found in the B cell areas (primary follicles and germinal centers) of lymphoid tissue. They are unrelated to the dendritic cell associated with T cells. Follicular dendritic cells have Fc receptors and C3b receptors, but unlike other dendritic cells, they do not process or present antigen in a way that allows recognition by T cells. Instead, they hold antigen in the form of immune complexes on their surfaces for long periods and can present antigen to B cells during an immune response." [ISBN:127520252] comment: Due to its unique lineage and distinct function, this is not a type of dendritic cell; CL:0000451. subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset xref: BTO:0004267 xref: FMA:83037 xref: MESH:D020566 is_a: CL:0000451 ! dendritic cell property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/2d-ftu/spleen-red-pulp/v1.2/assets/2d-ftu-spleen-red-pulp.png" xsd:string {terms:licence="http://creativecommons.org/licenses/by/4.0/", xref="doi:10.48539/HBM355.ZFMS.256"} property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/2d-ftu/spleen-white-pulp/v1.2/assets/2d-ftu-spleen-white-pulp.png" xsd:string {terms:licence="http://creativecommons.org/licenses/by/4.0/", xref="doi:10.48539/HBM559.FNBB.6273"} property_value: RO:0002175 NCBITaxon:9606 property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0000442" xsd:string {name="follicular dendritic cell on CELLxGENE CellGuide"} property_value: terms:description "Follicular dendritic cells (FDCs) are specialized cells found in B cell follicles in secondary lymphoid organs such as lymph nodes and spleen. FDCs play a key role in the immune response by presenting antigens to B-cells, which are responsible for producing antibodies. They accomplish this by acquiring antigens via multiple pathways and retaining them in non-degradative endosomal vesicles which cycle to the cell surface, allowing B-cells to encounter and recognize native antigens. In addition, FDCs secrete various cytokines and chemokines that direct immune cells to sites of infection or inflammation.\nFDCs are unique among immune cells in that they do not originate from hematopoietic stem cells, but rather from stromal cells in the lymphoid tissues. They are characterized by their distinctive shape, with long, branching processes that form a network within the follicle. FDCs are also distinguished by the presence of complement receptors, Fc receptors, and other molecules that enable them to capture and present antigens to B-cells.\nBecause of their important role in antigen presentation and immune regulation, FDCs have been studied extensively in the context of infectious diseases, autoimmunity, and cancer. Notably, FDCs appear to function as a reservoir for HIV, contribute to autoimmune pathology by presenting autoantigens, and drive FDC sarcoma.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1002/jcp.30662", xref="DOI:10.1038/nri3689", xref="DOI:10.3389/fimmu.2016.00225"} [Term] id: CL:0000443 name: calcitonin secreting cell def: "Any secretory cell that is capable of some calcitonin secretion." [FBC:Autogenerated] subset: human_subset subset: mouse_subset xref: ZFA:0009206 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000167 ! peptide hormone secreting cell intersection_of: CL:0000151 ! secretory cell intersection_of: RO:0002215 GO:0036161 ! capable of calcitonin secretion relationship: RO:0002215 GO:0036161 ! capable of calcitonin secretion [Term] id: CL:0000444 name: obliquely striated muscle cell def: "A muscle cell in which the fibers are organised into sarcomeres but in which adjacent myofibrils are offset from each other, producing an oblique banding pattern." [GOC:DOS, PMID:8720463] comment: Examples include the somatic muscles of nemotodes and cephalopods. subset: human_subset subset: mouse_subset is_a: CL:0000737 ! striated muscle cell intersection_of: CL:0000187 ! muscle cell intersection_of: BFO:0000051 GO:0030017 ! has part sarcomere intersection_of: RO:0000053 PATO:0002479 ! has characteristic obliquely striated relationship: RO:0000053 PATO:0002479 ! has characteristic obliquely striated [Term] id: CL:0000445 name: apoptosis fated cell subset: human_subset subset: mouse_subset is_a: CL:0000000 ! cell [Term] id: CL:0000446 name: chief cell of parathyroid gland def: "An epithelial cell of the parathyroid gland that is arranged in wide, irregular interconnecting columns; responsible for the synthesis and secretion of parathyroid hormone." [FMA:69078, GOC:tfm, ISBN:0517223651] subset: human_subset subset: mouse_subset synonym: "parathyroid chief cell" EXACT [] synonym: "parathyroid gland chief cell" EXACT [] synonym: "parathyroid hormone secreting cell" EXACT [] synonym: "principal cell of parathyroid gland" EXACT [] xref: BTO:0004712 xref: CALOHA:TS-2140 xref: FMA:69078 is_a: CL:1001593 ! parathyroid glandular cell relationship: BFO:0000050 UBERON:0011197 ! part of parathyroid epithelium relationship: RO:0002215 GO:0035898 ! capable of parathyroid hormone secretion [Term] id: CL:0000447 name: carbohydrate secreting cell subset: human_subset subset: mouse_subset is_a: CL:0000151 ! secretory cell property_value: skos:prefLabel "carbohydrate secreting cell" xsd:string [Term] id: CL:0000448 name: white adipocyte def: "An adipocyte with light coloration and few mitochondria. It contains a scant ring of cytoplasm surrounding a single large lipid droplet or vacuole." [GOC:tfm, MESH:D052438] subset: human_subset subset: mouse_subset synonym: "white adipose cell" EXACT [] synonym: "white fat cell" RELATED [] xref: CALOHA:TS-1119 xref: FMA:83434 is_a: CL:0000136 ! adipocyte relationship: BFO:0000050 UBERON:0001347 ! part of white adipose tissue relationship: RO:0002202 CL:0002334 ! develops from preadipocyte property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0000448" xsd:string {name="white adipocyte on CELLxGENE CellGuide"} property_value: terms:description "White fat cells, also known as white adipocytes, are cells found primarily in the white adipose tissue, a specialized type of connective tissue that functions as the major storage site for energy in the form of lipids. This type of adipose cell is characterized by its large droplets of liquid fat, called triglycerides, which almost completely fill the cell pushing the nucleus and other organelles to the periphery. They appear white or yellowish in color due to their high cytoplasm lipid content.\nWhite fat cells are involved in lipogenesis, the metabolic process where excess glucose and other energy-rich compounds are converted into neutral fats for storage. Conversely, these cells also play a pivotal role in lipolysis, the breakdown of triglycerides to release glycerol and fatty acids, when required by the body. Moreover, these cells act as thermal insulators, helping to maintain the body's temperature.\nImportantly, white fat cells are crucial for the proper functioning of numerous physiological processes including appetite regulation, inflammatory response, and immunity. They are also known to secrete various hormones and cytokines, such as leptin and adiponectin, which are instrumental in regulating metabolic activities and maintaining overall metabolic homeostasis. Dysregulation of these cells, along with an accumulation of excess white fat, has been linked to several health issues including obesity, metabolic syndrome, and type 2 diabetes.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1016/j.arcmed.2008.09.005", xref="DOI:10.1038/s41574-019-0230-6", xref="DOI:10.1038/s41574-021-00471-8", xref="DOI:10.1038/s42255-021-00493-6", xref="DOI:10.1146/annurev.nutr.27.061406.093734"} [Term] id: CL:0000449 name: brown adipocyte def: "A cell from the thermogenic form of adipose tissue found in many species, particularly in newborns and hibernating mammals, but also in lesser amounts in adults of other mammals including humans. Brown fat is capable of rapid liberation of energy and seems to be important in the maintenance of body temperature immediately after birth and upon waking from hibernation." [MESH:D002001] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "brown adipose cell" EXACT [] synonym: "brown fat cell" EXACT [] xref: CALOHA:TS-0099 xref: FMA:83435 is_a: CL:0000136 ! adipocyte relationship: BFO:0000050 UBERON:0001348 ! part of brown adipose tissue relationship: RO:0002202 CL:0002335 ! develops from brown preadipocyte property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0000449" xsd:string {name="brown adipocyte on CELLxGENE CellGuide"} property_value: terms:description "Brown fat cells, also known as brown adipocytes, form a type of adipose tissue that regulates energy by thermogenesis (heat production). These cells are rich in mitochondria, which lends them their characteristic brown colouring. Mitochondria are crucial to the brown fat cell's function since they contain an integral protein called uncoupling protein 1 (UCP1). This protein permits protons to leak across the mitochondrial inner membrane, disrupting the usual pathway of ATP production. Instead of generating ATP, the energy derived from glucose and fatty acids is dissipated as heat. This unique function makes brown fat cells an important biological tool for regulating body temperature, especially in infants and hibernating animals.\nWhile historically believed to be primarily relevant in newborns, recent findings highlight a role of brown fat cells in adults as well. They provide significant health benefits by metabolising excess glucose in the body and burning unwanted fat, and thereby raising the possibilities of using brown fat cells therapeutically for conditions like obesity or diabetes. Furthermore, stimulation of brown fat activity in adults is linked with improved overall metabolic health and lower risk of metabolic syndrome.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1007/164_2018_118", xref="DOI:10.1042/BJ20130457", xref="DOI:10.1074/jbc.M000547200", xref="DOI:10.1097/MED.0b013e328337a81f", xref="DOI:10.4161/adip.18951"} [Term] id: CL:0000451 name: dendritic cell def: "A cell of hematopoietic origin, typically resident in particular tissues, specialized in the uptake, processing, and transport of antigens to lymph nodes for the purpose of stimulating an immune response via T cell activation. These cells are lineage negative (CD3-negative, CD19-negative, CD34-negative, and CD56-negative)." [GOC:add, ISBN:0781735149] subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "interdigitating cell" RELATED [] synonym: "veiled cell" RELATED [] xref: BTO:0002042 xref: CALOHA:TS-0194 xref: FMA:83036 xref: MESH:D003713 xref: ZFA:0009209 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000113 ! mononuclear phagocyte is_a: CL:0000145 ! professional antigen presenting cell intersection_of: CL:0000738 ! leukocyte intersection_of: BFO:0000051 GO:0042613 ! has part MHC class II protein complex intersection_of: CL:4030046 PR:000001002 ! lacks_plasma_membrane_part CD19 molecule intersection_of: CL:4030046 PR:000001003 ! lacks_plasma_membrane_part CD34 molecule intersection_of: CL:4030046 PR:000001020 ! lacks_plasma_membrane_part CD3 epsilon intersection_of: CL:4030046 PR:000001024 ! lacks_plasma_membrane_part neural cell adhesion molecule 1 intersection_of: CL:4030046 PR:000001289 ! lacks_plasma_membrane_part membrane-spanning 4-domains subfamily A member 1 intersection_of: RO:0000053 PATO:0001407 ! has characteristic mononucleate intersection_of: RO:0002215 GO:0001816 ! capable of cytokine production intersection_of: RO:0002215 GO:0002504 ! capable of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II intersection_of: RO:0002215 GO:0019882 ! capable of antigen processing and presentation intersection_of: RO:0002215 GO:0045580 ! capable of regulation of T cell differentiation disjoint_from: CL:0000542 ! lymphocyte relationship: BFO:0000051 GO:0042613 ! has part MHC class II protein complex relationship: CL:4030046 PR:000001002 ! lacks_plasma_membrane_part CD19 molecule relationship: CL:4030046 PR:000001003 ! lacks_plasma_membrane_part CD34 molecule relationship: CL:4030046 PR:000001020 ! lacks_plasma_membrane_part CD3 epsilon relationship: CL:4030046 PR:000001024 ! lacks_plasma_membrane_part neural cell adhesion molecule 1 relationship: CL:4030046 PR:000001289 ! lacks_plasma_membrane_part membrane-spanning 4-domains subfamily A member 1 relationship: RO:0002215 GO:0001816 ! capable of cytokine production relationship: RO:0002215 GO:0045580 ! capable of regulation of T cell differentiation property_value: RO:0002175 NCBITaxon:9606 property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0000451" xsd:string {name="dendritic cell on CELLxGENE CellGuide"} property_value: terms:description "Dendritic cells, named for their tree-like extensions called dendrites, are a type of immune cell that form a critical bridge between the innate and adaptive immune systems. They are derived from hematopoietic bone marrow progenitor cells and can be found throughout the body poised as sentinels in locations such as the skin, lungs, or liver, as well as immune organs such as the thymus, lymph nodes, or spleen. They can also be found in an immature state in the blood. Dendritic cells serve as antigen-presenting cells, with a primary function of processing and presenting antigens to T-cells to facilitate an immune response.\nUpon encountering an antigen, dendritic cells engulf the pathogen via phagocytosis and subsequently process the pathogen into antigens. These antigens are then presented on the surface of the dendritic cell in the context of major histocompatibility complex (MHC) molecules. The dendritic cell migrates to the lymph nodes, containing naive T-cells, and presents the antigens to them. This process triggers the activation of cognate T-cells into effector T-cells, which can then recognize and eradicate cells bearing the same antigen.\nAdditionally, the dendritic cells can influence the type of immune response the body will mount. They communicate with T-cells through the use of co-stimulatory molecules and cytokines. Depending on the type of co-stimulatory molecules used and the set of cytokines released, dendritic cells can promote the development of a cellular immune response, dominated by cytotoxic T cells effective against intracellular pathogens such as viruses, a humoral response, mediated by B cells and effective against extracellular bacteria and toxins, or a tolerogenic response. Thus, dendritic cells play a pivotal role in immunity, helping the body to effectively combat infections, prevent autoimmune diseases, and maintain tolerance to healthy self-tissues.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1016/bs.ircmb.2019.07.004", xref="DOI:10.1038/nri.2016.116", xref="DOI:10.1111/imm.12888", xref="DOI:10.1146/annurev-immunol-061020-053707", xref="DOI:10.1146/annurev-immunol-100311-102839"} [Term] id: CL:0000452 name: obsolete thyroid hormone secreting cell comment: This term is redundant and has been merged with thyroid follicular cell property_value: IAO:0000233 https://github.com/obophenotype/cell-ontology/issues/3161 is_obsolete: true replaced_by: CL:0002258 [Term] id: CL:0000453 name: Langerhans cell def: "Langerhans cell is a conventional dendritic cell that has plasma membrane part CD207. A Langerhans cell is a stellate dendritic cell of myeloid origin, that appears clear on light microscopy and has a dark-staining, indented nucleus and characteristic inclusions (Birbeck granules) in the cytoplasm; Langerhans cells are found principally in the stratum spinosum of the epidermis, but they also occur in other stratified epithelia and have been identified in the lung, lymph nodes, spleen, and thymus." [GO_REF:0000031, GOC:add, GOC:amm, ISBN:0721601464, ISBN:0781735149, PMCID:PMC2346585, PMID:17850486] comment: Originally described in the dendritic cell ontology (DC_CL:0000021 )(PMID:19243617). These cells are also CD1a-high, CD14-negative, CD207-positive (langerin), CD324-positive (E-cadherin), and DCIR-positive. They reside in the epidermis. subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "LC" EXACT [] xref: BTO:0000705 xref: CALOHA:TS-2375 xref: FMA:63072 xref: MESH:D007801 is_a: CL:0000766 ! myeloid leukocyte is_a: CL:0000990 {is_inferred="true"} ! conventional dendritic cell intersection_of: CL:0000990 ! conventional dendritic cell intersection_of: RO:0002104 PR:000001293 ! has plasma membrane part C-type lectin domain family 4 member K intersection_of: RO:0002215 GO:0002828 ! capable of regulation of type 2 immune response relationship: RO:0002104 PR:000001293 ! has plasma membrane part C-type lectin domain family 4 member K relationship: RO:0002202 CL:0000763 ! develops from myeloid cell relationship: RO:0002215 GO:0002828 ! capable of regulation of type 2 immune response property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0000454 name: epinephrine secreting cell def: "A cell capable of producing epinephrine. Epiniphrine is synthesized from norepiniphrine by the actions of the phenylethanolamine N-methyltransferase enzyme, which is expressed in the adrenal glands, androgenic neurons, and in other cell types." [GOC:tfm, PMID:12438093] subset: human_subset subset: mouse_subset synonym: "adrenaline secreting cell" EXACT [GO:0048242] synonym: "epinephrin secreting cell" EXACT [] xref: ZFA:0009211 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000457 ! biogenic amine secreting cell intersection_of: CL:0000151 ! secretory cell intersection_of: RO:0002215 GO:0048242 ! capable of epinephrine secretion relationship: RO:0002215 GO:0048242 ! capable of epinephrine secretion [Term] id: CL:0000455 name: obsolete starch sheath cell def: "Obsolete. Use PO:0004531 from Plant Ontology instead. A cell characterized by conspicuous and rather stable accumulation of starch." [ISBN:044174520] is_obsolete: true replaced_by: PO:0004531 [Term] id: CL:0000456 name: mineralocorticoid secreting cell def: "Any secretory cell that is capable of some mineralocorticoid secretion." [FBC:Autogenerated] subset: human_subset subset: mouse_subset is_a: CL:0000174 ! steroid hormone secreting cell intersection_of: CL:0000151 ! secretory cell intersection_of: RO:0002215 GO:0035931 ! capable of mineralocorticoid secretion relationship: RO:0002215 GO:0035931 ! capable of mineralocorticoid secretion [Term] id: CL:0000457 name: biogenic amine secreting cell subset: human_subset subset: mouse_subset xref: ZFA:0009212 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000151 ! secretory cell property_value: skos:prefLabel "biogenic amine secreting cell" xsd:string [Term] id: CL:0000458 name: serotonin secreting cell def: "A cell type that secretes 5-Hydroxytryptamine (serotonin)." [GOC:tfm, PMID:19630576] subset: human_subset subset: mouse_subset synonym: "5-HT secreting cell" EXACT [] synonym: "5-Hydroxytryptamine secreting cell" EXACT [] xref: ZFA:0009213 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000457 ! biogenic amine secreting cell intersection_of: CL:0000151 ! secretory cell intersection_of: RO:0002215 GO:0001820 ! capable of serotonin secretion relationship: RO:0002215 GO:0001820 ! capable of serotonin secretion [Term] id: CL:0000459 name: noradrenergic cell def: "A cell capable of producting norepiniphrine. Norepiniphrine is a catecholamine with multiple roles including as a hormone and a neurotransmitter. In addition, epiniphrine is synthesized from norepiniphrine by the actions of the phenylethanolamine N-methyltransferase enzyme." [GOC:tfm, ISBN:068340007X] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "noradrenaline secreting cell" EXACT [] synonym: "norepinephrin secreting cell" EXACT [] synonym: "norepinephrine secreting cell" EXACT [] xref: ZFA:0009214 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000457 ! biogenic amine secreting cell intersection_of: CL:0000151 ! secretory cell intersection_of: RO:0002215 GO:0048243 ! capable of norepinephrine secretion relationship: RO:0002215 GO:0048243 ! capable of norepinephrine secretion property_value: skos:prefLabel "noradrenergic cell" xsd:string [Term] id: CL:0000460 name: glucocorticoid secreting cell def: "Any secretory cell that is capable of some glucocorticoid secretion." [FBC:Autogenerated] subset: human_subset subset: mouse_subset xref: ZFA:0009215 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000174 ! steroid hormone secreting cell intersection_of: CL:0000151 ! secretory cell intersection_of: RO:0002215 GO:0035933 ! capable of glucocorticoid secretion relationship: RO:0002215 GO:0035933 ! capable of glucocorticoid secretion [Term] id: CL:0000462 name: adepithelial cell def: "A cell of mesodermal origin that is closely associated with the epithelium of an imaginal disc. It is a precursor of some of the insect's adult muscles." [doi:10.1016/S0925-4773(97)00654-0] xref: FBbt:00003219 {sssom:mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"} is_a: CL:0000680 ! muscle precursor cell relationship: RO:0002162 NCBITaxon:50557 ! in taxon Insecta [Term] id: CL:0000463 name: epidermal cell (sensu Arthropoda) def: "An epidermal cell that secretes chitinous cuticle from its apical side." [FlyBase:ds, ISBN:ISBN\:978-0801481253] comment: While insect epidermis is generally columnar/cuboidal, there are certainly well studied cases where it is not (e.g.- Rhodnius prolixus when starved). So it would be safer to add this as a differentium for particular species where this is known. -DSJ. xref: FBbt:00007325 {sssom:mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"} is_a: CL:0000362 ! epidermal cell is_a: CL:0000710 ! neurecto-epithelial cell relationship: RO:0002162 NCBITaxon:6656 ! in taxon Arthropoda relationship: RO:0002202 CL:0000464 ! develops from epidermoblast [Term] id: CL:0000464 name: epidermoblast def: "An epidermal progenitor cell that arises from neuroectoderm and in turn gives rise to the epidermal sheath of ventral and cephalic regions." [GOC:tfm, PMID:7576311] subset: human_subset subset: mouse_subset xref: FBbt:00004994 {sssom:mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"} is_a: CL:0000710 ! neurecto-epithelial cell is_a: CL:0011026 ! progenitor cell relationship: RO:0002202 CL:0000114 ! develops from surface ectodermal cell [Term] id: CL:0000465 name: cardioblast (sensu Arthropoda) def: "A precursor of the cells that form the dorsal vessel of arthropods." [doi:10.1007/BF00360522] xref: FBbt:00001666 {sssom:mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"} is_a: CL:0010021 ! cardiac myoblast relationship: RO:0002162 NCBITaxon:6656 ! in taxon Arthropoda [Term] id: CL:0000467 name: adrenocorticotropic hormone secreting cell alt_id: CL:0000640 def: "A peptide hormone secreting cell that produces adrenocorticotropin, or corticotropin." [GOC:tfm, SANBI:mhl] subset: human_subset subset: mouse_subset synonym: "ACTH secreting cell" EXACT [GO:0051458] synonym: "adrenocorticotrophic hormone secreting cell" EXACT [] synonym: "corticotrophin hormone secreting cell" EXACT [] synonym: "corticotropin hormone secreting cell" EXACT [] synonym: "corticotropin secreting cell" EXACT [GO:0051458] xref: ZFA:0009216 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000167 ! peptide hormone secreting cell intersection_of: CL:0000151 ! secretory cell intersection_of: RO:0002215 GO:0051458 ! capable of corticotropin secretion relationship: RO:0002215 GO:0051458 ! capable of corticotropin secretion property_value: skos:prefLabel "adrenocorticotropic hormone secreting cell" xsd:string [Term] id: CL:0000468 name: neuroglioblast (sensu Nematoda and Protostomia) def: "A precursor of the central nervous system that gives rise to both neurons and glial cells." [doi:10.1002/glia.21162] synonym: "neuro-glioblast" EXACT [] synonym: "neuroglioblast" EXACT [] xref: FBbt:00005147 {sssom:mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"} is_a: CL:0000047 ! neural stem cell relationship: RO:0002162 NCBITaxon:33317 ! in taxon Protostomia [Term] id: CL:0000469 name: ganglion mother cell def: "A neural progenitor cell that is the daughter of a neuroblast (sensu arthopoda). The progeny of ganglion mother cells develop into neurons, glia and (occasionally) epithelial cells." [] xref: FBbt:00005149 {sssom:mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"} is_a: CL:0011020 ! neural progenitor cell relationship: RO:0002202 CL:0000338 ! develops from neuroblast (sensu Nematoda and Protostomia) [Term] id: CL:0000470 name: digestive enzyme secreting cell subset: human_subset subset: mouse_subset xref: ZFA:0009217 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000154 ! protein secreting cell [Term] id: CL:0000472 name: obsolete chlorenchyma cell def: "Obsolete. Use PO:0000076 from Plant Ontology instead. OBSOLETE, use term from Plant Ontology. Parenchyma cells containing chloroplasts; a component of leaf mesophyll and other green parenchyma tissue." [ISBN:0471245208] is_obsolete: true replaced_by: PO:0000076 [Term] id: CL:0000473 name: OBSOLETE defensive cell def: "OBSOLETE: A cell whose primary function is to protect the organism." [] comment: Unsustainable functional grouping term of dubious utility. property_value: IAO:0000233 https://github.com/obophenotype/cell-ontology/pull/3056 is_obsolete: true [Term] id: CL:0000474 name: pericardial nephrocyte def: "An insect renal cell that filters hemolymph and is found with other pericardial nephrocytes in two rows flanking the dorsal vessel." [FBbt:00003184, GO:0061320, GOC:tfm, PMID:19783135] synonym: "pericardial cell" NARROW [FBbt:00005058, GO:0061320] xref: FBbt:00005058 {sssom:mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"} is_a: CL:0000519 ! phagocyte (sensu Nematoda and Protostomia) is_a: CL:0002520 ! nephrocyte [Term] id: CL:0000475 name: obsolete degenerate megaspore def: "Obsolete. Use PO:0000245 from Plant Ontology instead. In monosporic and bisporic megasporogenesis: the megaspore(s) that do not participate in megagametogenesis." [TAIR:lr] is_obsolete: true replaced_by: PO:0000245 [Term] id: CL:0000476 name: thyrotroph def: "A basophil cell of the anterior pituitary that produces thyroid stimulating hormone, thyrotrophin. This cell type is elongated, polygonal and lie in clusters towards the adenohypophyseal center." [ISBN:0517223651, SANBI:mhl] subset: human_subset subset: mouse_subset synonym: "beta-basophil" EXACT [] synonym: "thyroid stimulating hormone secreting cell" EXACT [] synonym: "thyrotrope" EXACT [] xref: FMA:83099 xref: MESH:D052684 xref: ZFA:0009218 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000639 ! basophil cell of pars distalis of adenohypophysis relationship: RO:0002215 GO:0070460 ! capable of thyroid-stimulating hormone secretion [Term] id: CL:0000477 name: follicle cell of egg chamber def: "A somatic epithelial cell of the insect egg chamber." [] synonym: "follicle cell" BROAD [] synonym: "ovarian follicle cell" BROAD [] xref: FBbt:00004904 {sssom:mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"} is_a: BFO:0000002 is_a: CL:0000500 ! follicular epithelial cell relationship: BFO:0000050 UBERON:0000992 ! part of ovary relationship: RO:0002162 NCBITaxon:50557 {source="https://github.com/obophenotype/cell-ontology/issues/589"} ! in taxon Insecta relationship: RO:0002202 CL:0000441 ! develops from follicle stem cell (sensu Arthropoda) [Term] id: CL:0000478 name: oxytocin stimulating hormone secreting cell def: "A peptide hormone secreting cell that secretes oxytocin stimulating hormone" [GO:tfm] subset: human_subset subset: mouse_subset is_a: CL:0000167 ! peptide hormone secreting cell [Term] id: CL:0000479 name: vasopressin stimulating hormone secreting cell def: "A peptide hormone secreting cell that secretes vasopressin stimulating hormone" [GO:tfm] subset: human_subset subset: mouse_subset is_a: CL:0000167 ! peptide hormone secreting cell [Term] id: CL:0000480 name: secretin stimulating hormone secreting cell def: "A peptide hormone secreting cell that secretes secretin stimulating hormone" [GO:tfm] subset: human_subset subset: mouse_subset is_a: CL:0000167 ! peptide hormone secreting cell [Term] id: CL:0000481 name: cholecystokin stimulating hormone secreting cell def: "A peptide hormone secreting cell that secretes cholecystokin stimulating hormone." [GO:tfm] subset: human_subset subset: mouse_subset is_a: CL:0000167 ! peptide hormone secreting cell [Term] id: CL:0000482 name: juvenile hormone secreting cell def: "An endocrine cell that secretes juvenile hormone." [GO:tfm] subset: human_subset subset: mouse_subset xref: FBbt:00058020 {sssom:mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"} is_a: CL:0000151 ! secretory cell intersection_of: CL:0000151 ! secretory cell intersection_of: RO:0002215 GO:0045443 ! capable of juvenile hormone secretion relationship: RO:0002215 GO:0045443 ! capable of juvenile hormone secretion [Term] id: CL:0000483 name: bombesin stimulating hormone secreting cell def: "A peptide hormone secreting cell that secretes bombesin stimulating hormone." [GO:tfm, https://orcid.org/0000-0001-5208-3432] subset: human_subset subset: mouse_subset is_a: CL:0000167 ! peptide hormone secreting cell [Term] id: CL:0000484 name: connective tissue type mast cell def: "Mast cell subtype whose granules contain both the serine proteases tryptase and chymase. These cells are primarily found in connective tissue, such as the peritoneal cavity, skin, and intestinal submucosa. Their development is T-cell independent." [GOC:add, GOC:dsd, GOC:tfm, PMID:19923473, PMID:9354811] comment: They are CD88-positive. The cytoplasmic granules contain high levels of histamine and heparin (mouse) or major neutral proteases, tryptase, chymase, carboxypeptidase A, and cathepsin G (humans). Reportedly, they cannot produce leukotrienes (LTC4) and IL-4. They are reportedly very heterogeneous depending upon location and can convert to the MC(T) phenotype. subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "MC(TC)" EXACT [] synonym: "MCTC" EXACT [] synonym: "TC mast cells" EXACT [] is_a: CL:0000097 {is_inferred="true"} ! mast cell is_a: CL:0002320 ! connective tissue cell intersection_of: CL:0000097 ! mast cell intersection_of: BFO:0000050 UBERON:0002384 ! part of connective tissue property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0000485 name: mucosal type mast cell def: "Mast cell subtype that contains only the serine protease trypase in its granules. These cells are primarily found in mucosal tissue, such as intestinal mucosa and alveoli. They depend upon T-cells for development of phenotype." [GOC:add, GOC:dsd, PMID:19923473, PMID:9354811] comment: They are CD88-negative. The cytoplasmic granules contain low levels of histamine and high levels of chondroitin sulfate (mouse) or major neutral proteases and tryptase (humans). Additionally, they can produce leukotrienes (LTC4), IL-5, IL-6, and low levels of IL-4. They are reportedly very heterogeneous depending upon location and can convert to the MC(T) phenotype. subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "MC(T)" EXACT [] synonym: "MCT" EXACT [] synonym: "T mast cells" EXACT [] is_a: CL:0000097 {is_inferred="true"} ! mast cell intersection_of: CL:0000097 ! mast cell intersection_of: BFO:0000050 UBERON:0001961 ! part of mucosa-associated lymphoid tissue intersection_of: RO:0002215 GO:0002540 ! capable of leukotriene production involved in inflammatory response relationship: BFO:0000050 UBERON:0001961 ! part of mucosa-associated lymphoid tissue relationship: RO:0002215 GO:0002540 ! capable of leukotriene production involved in inflammatory response property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0000486 name: garland cell def: "A large binucleate cell that forms a 'garland' around the anterior end of the proventriculus (cardia) at its junction with the esophagus in both adults and larvae flies. Each cell is surrounded by a basement membrane and there are numerous micro-invaginations (lacunae) extending from the surface into the cytoplasm. At the mouth of each lacuna is a doubled filament forming a specialised filtration system (diaphragm). The filtrate is endocytosed from the lacunae." [fbbt:00005059, GOC:tfm, PMID:19783135] synonym: "garland nephrocyte" BROAD [GO:0061321] xref: BTO:0004596 xref: FBbt:00005059 {sssom:mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"} is_a: CL:0000227 ! binucleate cell is_a: CL:0000519 ! phagocyte (sensu Nematoda and Protostomia) is_a: CL:0002520 ! nephrocyte [Term] id: CL:0000487 name: oenocyte def: "A secretory cell of ectodermal origin. This cell may have important functions in fatty acid and hydrocarbon metabolism and is metabolically linked to the fat body and tracheae. This cell is exclusive of arthropods." [GOC:bf, https://www.merriam-webster.com/dictionary/oenocyte, PMID:11171397, PMID:24397521, PMID:34208190] comment: Oenocytes are highly variable in size, shape, cluster formation and anatomical location. In adults, oenocytes tend to be smaller but more numerous than in larvae. While oenocytes have been found in arachnids and crustaceans, they have been most abundantly described in insects. {xref="PMID:34208190", xref="PMID:24397521"} xref: FBbt:00004995 {sssom:mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"} is_a: CL:0000151 ! secretory cell is_a: CL:0000255 ! eukaryotic cell relationship: RO:0002162 NCBITaxon:6656 ! in taxon Arthropoda [Term] id: CL:0000488 name: visible light photoreceptor cell def: "A photoreceptor cell that detects visible light." [GOC:tfm] subset: human_subset subset: mouse_subset xref: ZFA:0009219 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000210 ! photoreceptor cell intersection_of: CL:0000210 ! photoreceptor cell intersection_of: RO:0002215 GO:0009584 ! capable of detection of visible light relationship: RO:0002215 GO:0009584 ! capable of detection of visible light [Term] id: CL:0000489 name: scotopic photoreceptor cell subset: human_subset subset: mouse_subset is_a: CL:0000210 ! photoreceptor cell [Term] id: CL:0000490 name: photopic photoreceptor cell subset: human_subset subset: mouse_subset xref: ZFA:0009220 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000488 ! visible light photoreceptor cell [Term] id: CL:0000491 name: obsolete cytotoxic T cell def: "OBSOLETE: A cell responsible for spontaneous cytotoxicity of a variety of tumor cells without prior immunization. These natural killer cells are found in non-immune humans and experimental animals and are thought by some to be the same as killer cells (killing by antibody-dependent cell cytotoxicity), but they can also kill in the absence of antibody." [] comment: This term had an incorrect definition and was overly broad. Consider using 'cytotoxic T cell ; CL:0000910' (in most cases) or another lymphocyte cell type if cytotoxicity is shown to be part of the cell's phenotype in a particular experimental situation. is_obsolete: true [Term] id: CL:0000492 name: CD4-positive helper T cell def: "A CD4-positive, alpha-beta T cell that cooperates with other lymphocytes via direct contact or cytokine release to initiate a variety of immune functions." [GO_REF:0000031, GOC:add, GOC:pam, GOC:tfm, ISBN:0781735149, MESH:D006377] subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "CD4-positive helper T lymphocyte" EXACT [] synonym: "CD4-positive helper T-cell" EXACT [] synonym: "CD4-positive helper T-lymphocyte" EXACT [] synonym: "CD4-positive T-helper cell" EXACT [] xref: CALOHA:TS-1146 xref: FMA:70572 is_a: CL:0000624 {is_inferred="true"} ! CD4-positive, alpha-beta T cell intersection_of: CL:0000624 ! CD4-positive, alpha-beta T cell intersection_of: RO:0002215 GO:0001816 ! capable of cytokine production relationship: RO:0002202 CL:0000896 ! develops from activated CD4-positive, alpha-beta T cell relationship: RO:0002215 GO:0001816 ! capable of cytokine production relationship: RO:0002353 GO:0030217 ! output of T cell differentiation property_value: RO:0002175 NCBITaxon:9606 property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0000492" xsd:string {name="CD4-positive helper T cell on CELLxGENE CellGuide"} property_value: terms:description "The CD4-positive helper T cells are a subpopulation of T lymphocytes, which are part of the adaptive immune system. These cells play a vital role in establishing and maximizing the capability of the immune system to combat infections. Like all T lymphocytes, CD4+ helper T cells are uniquely characterized by the expression of a T-cell receptor (TCR) complex on their cell surface. The subset of CD4+ cells express the CD4 glycoprotein on their cell surface that serves as a co-receptor for the T-cell receptor. The CD4 co-receptor enables these cells to interact with antigen-presenting cells and perform their influential role in adaptive immune response.\nCD4+ helper T cells are primarily responsible for assisting other cells in the immunological processes. This involves recognition, interaction, and processing of antigens. Once an antigen-presenting cell presents a foreign antigen such as peptides derived from pathogens or transformed cells to the CD4+ helper T cell, it becomes activated, proliferates, and differentiates into subtypes such as Th1, Th2, Th17, or Treg, each with a specific role in the immune response. Th1 cells produces various cytokines. including IFN‐γ, IL-2 and TNF-β, and aid cell-mediated immune responses against intracellular pathogens. Th2 cells produce IL-4, IL-5 and IL13 and assist in antibody-mediated immune responses. \nTh17 cells release IL-17 and convey protective immunity against extracellular bacteria and fungi as well as contributing to inflammation and autoimmunity, while Treg cells are immunosuppressive cells and maintain immune homeostasis and provide tolerance to self-antigens. Finally, follicular T helper (Tfh) cells are thought to help B cells build up antibody responses by assisting germinal center formation, affinity maturation, and possibly immunoglobulin class switch recombination \nIn addition to their critical role in immune response, CD4+ helper T cells are notably the main target of HIV infection, where the virus depletes the number of these cells, resulting in the deterioration of the immune system, characterized in the progression to AIDS. Thus, the presence and functionality of CD4+ helper T cells are not only necessary for a healthy immune response but also crucial in the context of immunodeficiency diseases.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1002/ctd2.199", xref="DOI:10.1038/s43018-023-00521-2", xref="DOI:10.1111/imcb.12662", xref="DOI:10.1146/annurev-immunol-103019-085803", xref="https://www.sciencedirect.com/topics/biochemistry-genetics-and-molecular-biology/t-helper-cell"} [Term] id: CL:0000493 name: obsolete regulatory T cell def: "OBSOLETE: Subpopulation of CD4+ cells which induce CD8+ suppressor T cells to suppress antibody production by B cells. They also stimulate other cellular immune responses." [] comment: This term was defined too narrowly; consider using the term 'regulatory T cell ; CL:0000815' instead. is_obsolete: true [Term] id: CL:0000494 name: UV sensitive photoreceptor cell def: "A photoreceptor cell that detects ultraviolet light." [GOC:tfm] subset: human_subset subset: mouse_subset xref: ZFA:0009221 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000210 ! photoreceptor cell intersection_of: CL:0000210 ! photoreceptor cell intersection_of: RO:0002215 GO:0009589 ! capable of detection of UV relationship: RO:0002215 GO:0009589 ! capable of detection of UV [Term] id: CL:0000495 name: blue sensitive photoreceptor cell def: "A photoreceptor cell that is sensitive to blue light." [GO:tfm] subset: human_subset subset: mouse_subset xref: ZFA:0009222 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000490 ! photopic photoreceptor cell [Term] id: CL:0000496 name: green sensitive photoreceptor cell def: "A photoreceptor cell that is sensitive to green light." [GO:tfm] subset: human_subset subset: mouse_subset xref: ZFA:0009223 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000490 ! photopic photoreceptor cell [Term] id: CL:0000497 name: red sensitive photoreceptor cell def: "A photoreceptor cell that is sensitive to red light." [GO:tfm] subset: human_subset subset: mouse_subset xref: ZFA:0009224 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000490 ! photopic photoreceptor cell [Term] id: CL:0000498 name: inhibitory interneuron def: "An interneuron (also called relay neuron, association neuron or local circuit neuron) is a multipolar neuron which connects afferent neurons and efferent neurons in neural pathways. Like motor neurons, interneuron cell bodies are always located in the central nervous system (CNS)." [GOC:tfm, http://en.wikipedia.org/wiki/Interneuron] subset: cellxgene_subset subset: human_subset subset: mouse_subset xref: FMA:84776 xref: ZFA:0009225 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000099 ! interneuron property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0000498" xsd:string {name="inhibitory interneuron on CELLxGENE CellGuide"} property_value: skos:prefLabel "inhibitory interneuron" xsd:string property_value: terms:description "Inhibitory interneurons, often referred to as local circuit neurons, are integral components of the central nervous system where they play key roles in refining neural circuits and shaping network activity. Known for their inhibitory nature, these neurons form connections mainly within the same region of the brain or spinal cord where they are located. This localization allows them to impact the activities of nearby excitatory neurons by means of inhibitory networks to inhibit or reduce the likelihood of the firing of these excitatory neurons.\nFunctionally, Inhibitory Interneurons serve as primary regulators and modulators of the output of nerve cells, orchestrating a balance between excitatory and inhibitory activities in neural networks. It is through their characteristic release of inhibitory neurotransmitters, such as gamma-aminobutyric acid (GABA) and glycine, that they manage to suppress postsynaptic potentials, preventing or reducing the propagation of action potentials. This regulation is not only essential for maintaining equilibrium within the nervous system, but also helps prevent conditions that arise from excessive neuronal activities, such as epilepsy.\nInhibitory Interneurons, while relatively small in number compared to their excitatory counterparts, exhibit considerable diversity in their structure, function, and neurochemical expression. They are broadly categorized into multiple subtypes, each with its unique influence on neural circuit behavior and role in different behaviors or cognitive processes. For instance, certain subtypes are involved with timing and synchrony of neural activity, while others participate in contrast enhancement in sensory processing or in isolating specific activity patterns.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1007/s12576-016-0442-7", xref="DOI:10.1016/j.neuropharm.2014.09.011", xref="DOI:10.1038/nature25999", xref="DOI:10.1152/physrev.00007.2017", xref="DOI:10.1523/JNEUROSCI.23-02-00622.2003"} [Term] id: CL:0000499 name: stromal cell def: "A connective tissue cell of an organ found in the loose connective tissue." [GOC:tfm, MESH:D017154] subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset xref: BTO:0002064 xref: FMA:83624 xref: ZFA:0009226 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: BFO:0000002 is_a: CL:0002320 ! connective tissue cell relationship: RO:0002202 CL:0000134 ! develops from mesenchymal stem cell property_value: RO:0002175 NCBITaxon:9606 property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0000499" xsd:string {name="stromal cell on CELLxGENE CellGuide"} property_value: skos:prefLabel "stromal cell" xsd:string property_value: terms:description "Stromal cells constitute a significant portion of the structural cellular milieu (stroma) that supports the function of parenchymal (functional) cells within an organ. The stroma is the connective, supportive framework of biological tissues with various functions depending on the specific organ and cell type. Stromal cells, derived from the mesenchymal lineage, play crucial roles in creating, maintaining, and repairing the tissue microenvironment in virtually all mammalian organs, making these cells indispensable to biological function.\nAdditionally, stromal cells secrete growth factors, cytokines, and extracellular matrix (ECM) molecules to constitute an interactive cellular network and ensure an optimal environment for the functional cells. Beyond mere structural support, these cells are instrumental in wound healing, inflammation, and maintaining tissue integrity. They may also influence the behavior of other cell types through direct cell-cell interactions or paracrine signaling.\nClinically and in research, stromal cells often draw attention due to their interaction with tumors in the cancer microenvironment. Over the past years, the role of stromal cells as facilitators of tumor growth and metastasis has been recognized increasingly. They contribute to cancer progression not only by modulating the ECM but also through the secretion of various bioactive molecules and interacting with immune cells, thereby influencing the immunologic responses to tumors.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1038/nri2588", xref="DOI:10.1038/s41536-019-0083-6", xref="DOI:10.1186/s13058-016-0740-2", xref="DOI:10.1634/stemcells.2007-0637", xref="DOI:10.3389/fcell.2020.555378"} [Term] id: CL:0000500 name: follicular epithelial cell def: "An epithelial somatic cell associated with a maturing oocyte." [] subset: human_subset subset: mouse_subset is_a: CL:0000066 ! epithelial cell [Term] id: CL:0000501 name: granulosa cell def: "A supporting cell for the developing female gamete in the ovary of mammals. They develop from the coelomic epithelial cells of the gonadal ridge. Granulosa cells form a single layer around the mammalian oocyte in the primordial ovarian follicle and advance to form a multilayered cumulus oophorus surrounding the ovum in the Graafian follicle. The major functions of granulosa cells include the production of steroids and LH receptors." [MESH:D006107] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "granulosa cell of ovary" EXACT [] xref: BTO:0000542 xref: CALOHA:TS-0729 xref: FMA:18718 xref: ZFA:0009227 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: BFO:0000002 is_a: CL:0000174 ! steroid hormone secreting cell is_a: CL:0002174 ! follicular cell of ovary relationship: RO:0002202 CL:4033066 ! develops from pre-granulosa cell property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0000501" xsd:string {name="granulosa cell on CELLxGENE CellGuide"} property_value: terms:description "Granulosa cells are a type of somatic cell most commonly known for their crucial role within the ovarian follicles of female mammalian species. Named for their grainy appearance, they are situated in the follicular epithelium, lining the inner part of the follicle and directly surrounding the oocyte. These cells stand as an integral part of the ovarian structure and function.\nOne of the primary roles of granulosa cells is to aid in the production and secretion of sex hormones, particularly estrogen. They achieve this by working in tandem with theca cells, which stay attached to the external layer of the follicle. Theca cells produce androstenedione (a type of androgen) which granulosa cells then convert into estradiol, a form of estrogen, with the help of the enzyme aromatase. Moreover, granulosa cells participate in luteinization, transforming into luteal granulosa cells as a response to the luteinizing hormone during ovulation. This allows the formation of the corpus luteum, responsible for the secretion of progesterone necessary to maintain pregnancy.\nGranulosa cells also play a significant role in follicular development and oocyte maturation, involving close communication with the contained oocyte. They support the oocyte through the provision of nutrients and growth factors, control its meiotic cycle and ensure it is appropriately oriented and instructed for impending ovulation. Furthermore, granulosa cells contribute to the formation of the zona pellucida and the follicular fluid, providing an optimal environment for the oocyte's growth and maturation. These cells, thus, perform multiple vital roles, underscoring their importance in fertility and reproductive health.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1016/j.ejogrb.2004.01.010", xref="DOI:10.1093/humrep/del408", xref="DOI:10.1093/humupd/6.3.279", xref="DOI:10.1210/jcem-28-3-355", xref="DOI:10.3389/fendo.2019.00832/full"} [Term] id: CL:0000502 name: type D enteroendocrine cell def: "A cell found throughout the gastrointestinal tract and in the pancreas. They secrete somatostatin in both an endocrine and paracrine manner. Somatostatin inhibits gastrin, cholecystokinin, insulin, glucagon, pancreatic enzymes, and gastric hydrochloric acid. A variety of substances which inhibit gastric acid secretion (vasoactive intestinal peptide, calcitonin gene-related peptide, cholecystokinin, beta-adrenergic agonists, and gastric inhibitory peptide) are thought to act by releasing somatostatin." [MESH:D019864] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "D cell" EXACT [] xref: FMA:62935 xref: ZFA:0009228 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000164 ! enteroendocrine cell is_a: CL:0000165 ! neuroendocrine cell is_a: CL:0000172 ! somatostatin secreting cell property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0000502" xsd:string {name="type D enteroendocrine cell on CELLxGENE CellGuide"} property_value: terms:description "Type D enteroendocrine cells, also known as D or delta cells, are specialized hormone-releasing cells found in the pancreas and also scattered throughout the lining of the gastrointestinal tract in mammals, notably within the stomach and the upper part of the small intestine known as the duodenum. The primary role of D cells is to produce and secrete somatostatin, a potent paracrine inhibitor. \nIn the gastrointestinal tract, somatostatin slows down digestion. It reduces gastric acid secretion and slows down the rate of gastric emptying, thereby prolonging and controling the digestive p. Functionally, these effects are aimed at sustaining nutrient absorption to optimize energy extraction from consumed food.\nIn the pancreas, D cells maintain a vital role in endocrine regulation. D cells in the pancreatic islands secrete somatostatin to inhibit the release of both insulin and glucagon from type A cells and B cells, glucoregulatory hormones that control blood sugar levels. Hence, D cells contribute considerably to the homeostasis of the body's metabolic processes. It is also noteworthy that dysfunctional D cells or irregular somatostatin signaling has been associated with certain pathologies such as neuroendocrine tumors and gastric ulcers.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1016/j.pharmthera.2015.05.007", xref="DOI:10.1038/s41574-018-0020-6", xref="DOI:10.1093/annonc/mdh216", xref="https://www.sciencedirect.com/topics/neuroscience/somatostatin-cell"} [Term] id: CL:0000503 name: theca cell def: "A specialized stromal cell that forms the theca layer outside the basal lamina lining the ovarian follicle, appearing during the secondary follicle stage." [MESH:D013799, PMID:15833266, PMID:36758341] subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset xref: BTO:0002850 xref: ZFA:0009229 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0002132 ! stromal cell of ovary is_a: CL:0002174 ! follicular cell of ovary relationship: BFO:0000050 UBERON:0000155 ! part of theca cell layer property_value: RO:0002175 NCBITaxon:9606 property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0000503" xsd:string {name="theca cell on CELLxGENE CellGuide"} property_value: terms:description "Theca cells are specialized stromal cells found within the ovaries, more specifically in the follicles that house and nurture the developing ovum. They exist in two forms: theca interna cells and theca externa cells, both playing significant roles in ovarian function and the reproductive system as a whole. Found in all mammalian species, these cells allow intricate processes like ovulation and hormonal control to function seamlessly.\nTheca interna cells are highly vascularized and specialized to produce androgens, specifically androstenedione, a precursor to estradiol. When the follicle-stimulating hormone (FSH) stimulates granulosa cells to produce aromatase, this enzyme then converts the androgens into estrogens. Consequently, the hormonal interaction between theca interna cells and granulosa cells supports the production of estrogen necessary for the reproductive cycle. \nTheca externa cells, on the other hand, are mechanically supportive cells. They form an outer protective layer around the follicle. While they do not directly influence hormone production, they play an essential role in structural integrity and act in concert with the granulosa and theca interna cells during the rupture of the mature ovarian follicle, releasing the egg for potential fertilization. Simultaneously, these cells participate in the formation of the corpus luteum, which secretes progesterone to prepare the uterus for potential implantation.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1016/j.biocel.2005.01.016", xref="DOI:10.1038/ncomms7934", xref="DOI:10.1097/CM9.0000000000000850", xref="DOI:10.1155/2015/925691", xref="DOI:10.1210/er.2017-00164"} [Term] id: CL:0000504 name: enterochromaffin-like cell def: "A enteroendocrine cell part of the glands of the gastric mucosa. They produce histamine and peptides such as chromogranins. This cell type respond to gastrin by releasing histamine which acts as a paracrine stimulator of the release of hydrochloric acid from the gastric parietal cells." [GOC:tfm, MESH:D019861] comment: Consider enterochromaffin cell (CL:0002065). For several years this cell type was "enterochromaffin cell" despite a MESH dbxref and a free text definition that clearly meant enterochromaffin-like cell. subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "ECL" EXACT [] xref: BTO:0002692 is_a: CL:0000164 ! enteroendocrine cell is_a: CL:0002274 ! histamine secreting cell [Term] id: CL:0000505 name: substance P secreting cell def: "A peptide hormone secreting cell that secretes substance P." [GO:tfm] subset: human_subset subset: mouse_subset xref: ZFA:0009230 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000167 ! peptide hormone secreting cell [Term] id: CL:0000506 name: enkephalin secreting cell def: "An endorphine cell that secretes enkephalin." [GO:tfm] subset: human_subset subset: mouse_subset xref: ZFA:0009231 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000507 ! endorphin secreting cell [Term] id: CL:0000507 name: endorphin secreting cell def: "A peptide hormone secreting cell that secretes endorphin." [GO:tfm] subset: human_subset subset: mouse_subset xref: ZFA:0009232 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000167 ! peptide hormone secreting cell [Term] id: CL:0000508 name: type G enteroendocrine cell def: "An endocrine cell found in the stomach and duodenum and is responsible for the secretion of gastrin and enkephalin. Most abundant in pyloric antrum, pyramidal in form with a narrow apex bearing long microvilli." [GOC:tfm, ISBN:0517223651, MESH:D019863, PMID:10700044, PMID:35674015, PMID:37240181] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "G cell" EXACT [] xref: BTO:0004108 xref: FMA:67609 is_a: CL:0000164 ! enteroendocrine cell is_a: CL:0000165 ! neuroendocrine cell is_a: CL:0000506 ! enkephalin secreting cell is_a: CL:0000509 ! gastrin secreting cell [Term] id: CL:0000509 name: gastrin secreting cell def: "A peptide hormone secreting cell that secretes gastrin." [GO:tfm] subset: human_reference_atlas subset: human_subset subset: mouse_subset is_a: CL:0000167 ! peptide hormone secreting cell property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0000510 name: paneth cell def: "An epithelial cell found in the basal part of the intestinal glands (crypts of Lieberkuhn) including the appendix. Paneth cells synthesize and secrete lysozyme and cryptdins. Numerous in the deeper parts of the intestinal crypts, particularly in the duodenum, rich in zinc, contain large acidophilic granules, with irregular apical microvilli and prominent membrane-bound vacuoles containing matrix." [GOC:tfm, ISBN:0517223651, MESH:D019879, PMID:29184701, PMID:32308658, PMID:33484640] subset: cellxgene_subset subset: human_subset subset: mouse_subset xref: BTO:0000993 xref: FMA:62897 is_a: CL:0000150 ! glandular secretory epithelial cell is_a: CL:0000323 ! lysozyme secreting cell is_a: CL:0002563 ! intestinal epithelial cell relationship: BFO:0000050 UBERON:0011184 ! part of epithelium of crypt of Lieberkuhn relationship: BFO:0000051 GO:0005773 ! has part vacuole relationship: BFO:0000051 GO:0005902 ! has part microvillus relationship: RO:0002202 CL:4047017 ! develops from transit amplifying cell of gut property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0000510" xsd:string {name="paneth cell on CELLxGENE CellGuide"} property_value: terms:description "Paneth cells are specialized epithelial cells that are primarily located at the bottom of the crypts of Lieberkühn in the small intestine, where they play a pivotal role in maintaining gut homeostasis. They have also been found in smaller numbers in the colonic crypts and other parts of the gastrointestinal tract. Paneth cells are characterized by large acidophilic granules, which take up most of the cytoplasmic volume, causing the nucleus to be pushed toward the base of the cell.\nPaneth cells function as a part of the innate immune system. The large granules inside the cells are filled with antimicrobial peptides, such as defensins and lysozymes. Upon bacterial intrusion or cellular signaling indicating a potential infection, Paneth cells release the granules containing the antimicrobial substances into the crypt lumen, effectively serving as the first line of defense against bacterial invasion within the gastrointestinal tract. In essence, Paneth cells serve as guardians, protecting the intestinal stem cells from harmful pathogens that may disturb the gut ecosystem.\nIn addition to their primary role in immunity, Paneth cells are also crucial for supporting the stem cell niche in the intestinal crypts. They are located adjacent to Lgr5+ stem cells and secrete various growth factors such as EGF, TGF-alpha, Wnt3, and Notch ligand Dll4. These factors regulate the self-renewal and differentiation of these stem cells, which continuously replenish the intestinal epithelium. Consequently, any abnormality or dysfunction in Paneth cells could lead to a disturbance in gut homeostasis, possibly resulting in various illnesses such as inflammatory bowel disease.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1007/s00018-002-8412-z", xref="DOI:10.1038/nature09637", xref="DOI:10.1038/nrmicro2546", xref="DOI:10.1146/annurev-physiol-030212-183744", xref="DOI:10.3389/fimmu.2020.00587"} [Term] id: CL:0000511 name: androgen binding protein secreting cell def: "A peptide hormone secreting cell that secretes androgen binding protein." [GO:tfm] subset: human_subset subset: mouse_subset is_a: CL:0000154 ! protein secreting cell [Term] id: CL:0000512 name: obsolete paracrine cell comment: The term paracrine describes a role of a secreted hormone. There are a vast number of cell types that could fit this description, however it is difficult to know every case where a secreted hormone has paracrine effects. is_obsolete: true consider: CL:0000151 [Term] id: CL:0000513 name: cardiac muscle myoblast alt_id: CL:0000714 def: "A precursor cell destined to differentiate into cardiac muscle cell." [GOC:tfm, MESH:D032386] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "cardiac muscle progenitor cell" EXACT [] synonym: "cardiomyocyte progenitor cell" EXACT [] xref: FMA:84797 xref: ZFA:0009234 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0002494 ! cardiocyte is_a: CL:0010021 ! cardiac myoblast intersection_of: CL:0000056 ! myoblast intersection_of: BFO:0000050 UBERON:0001133 ! part of cardiac muscle tissue intersection_of: RO:0002203 CL:0000746 ! develops into cardiac muscle cell relationship: BFO:0000050 UBERON:0001133 ! part of cardiac muscle tissue [Term] id: CL:0000514 name: smooth muscle myoblast def: "A precursor cell destined to differentiate into smooth muscle myocytes." [GOC:tfm, MESH:D032390] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "myoblast, smooth muscle" EXACT [MESH:D032390] synonym: "satellite cell" RELATED [] xref: FMA:84798 xref: ZFA:0009235 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000056 ! myoblast intersection_of: CL:0000056 ! myoblast intersection_of: RO:0002203 CL:0000192 ! develops into smooth muscle cell relationship: RO:0002203 CL:0000192 ! develops into smooth muscle cell property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0000514" xsd:string {name="smooth muscle myoblast on CELLxGENE CellGuide"} property_value: skos:prefLabel "smooth muscle myoblast" xsd:string property_value: terms:description "A precursor to the smooth muscle cell, the smooth muscle myoblast, is integral to various body systems, including the cardiovascular, gastrointestinal, and respiratory systems. Smooth muscle myoblasts arise from the differentiation of mesenchymal stem cells, a process tightly regulated by specific genetic factors and environmental signals. Their role extends to myogenesis, particularly in the formation of muscular tissue, especially during embryonic development.\nSmooth muscle myoblasts possess distinctive cellular characteristics. In contrast to skeletal muscle myoblasts, they do not fuse to create multinucleated fibers. Instead, they differentiate into individual, uninucleated smooth muscle cells. This differentiation unfolds in two distinct phases: proliferation, marked by rapid division to increase cell numbers, and differentiation, involving structural and functional transformation into mature smooth muscle cells. This intricate process is intricately mediated by various signaling molecules and transcription factors.\nFunctionally, smooth muscle myoblasts and the mature muscle cells they generate play pivotal roles in various physiological processes. Smooth muscle cells orchestrate involuntary muscle responses and are integral to body systems that regulate blood flow, propel food along the digestive tract, and control airflow in the respiratory tract. These diverse functions underscore the significance of smooth muscle myoblasts in the body's growth, maintenance, and overall function.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1074/jbc.RA118.001739", xref="https://www.ncbi.nlm.nih.gov/books/NBK544225/", xref="https://www.sciencedirect.com/topics/medicine-and-dentistry/smooth-muscle"} [Term] id: CL:0000515 name: skeletal muscle myoblast def: "A myoblast that differentiates into skeletal muscle fibers." [SANBI:mhl] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "skeletal myoblast" EXACT [] xref: FMA:84799 xref: ZFA:0009236 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000056 ! myoblast intersection_of: CL:0000056 ! myoblast intersection_of: RO:0002203 CL:0008002 ! develops into skeletal muscle fiber relationship: RO:0002202 CL:0000355 ! develops from multi-potent skeletal muscle stem cell relationship: RO:0002203 CL:0008002 ! develops into skeletal muscle fiber property_value: skos:prefLabel "skeletal muscle myoblast" xsd:string [Term] id: CL:0000516 name: perineuronal satellite cell def: "A non-neuronal cell that surrounds the neuronal cell bodies of the ganglia." [GOC:tfm, MESH:D027161] subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "perineural satellite cell" EXACT [] synonym: "perineuronal satellite oligodendroglial cell" EXACT [] synonym: "satellite oligodendrocyte" EXACT [] xref: FMA:54550 xref: ZFA:0009237 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000123 ! neuron associated cell (sensu Vertebrata) relationship: RO:0002202 CL:0000339 ! develops from glioblast (sensu Vertebrata) property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0000517 name: macrophage derived foam cell def: "A type of foam cell derived from a macrophage containing lipids in small vacuoles and typically seen in atherolosclerotic lesions, as well as other conditions." [GOC:add, PMID:20213546] subset: human_subset subset: mouse_subset synonym: "lipophage" EXACT [] is_a: BFO:0000002 is_a: CL:0000255 ! eukaryotic cell is_a: CL:0000891 ! foam cell relationship: RO:0002202 CL:0000235 ! develops from macrophage [Term] id: CL:0000518 name: phagocyte (sensu Vertebrata) def: "A phagocyte in vertebrates that is able to phagocytosis." [GOC:tfm] subset: human_subset subset: mouse_subset is_a: CL:0000234 ! phagocyte is_a: CL:0000255 ! eukaryotic cell relationship: RO:0002162 NCBITaxon:7742 ! in taxon Vertebrata [Term] id: CL:0000519 name: phagocyte (sensu Nematoda and Protostomia) def: "A phagocyte from organisms in the Nematoda or Protostomia clades." [GOC:tfm] is_a: CL:0000234 ! phagocyte property_value: RO:0002161 NCBITaxon:33511 [Term] id: CL:0000520 name: prokaryotic cell xref: MESH:D011387 is_a: CL:0000000 ! cell property_value: RO:0002161 NCBITaxon:2759 [Term] id: CL:0000521 name: fungal cell def: "Any cell that in taxon some Fungi." [FBC:Autogenerated] is_a: CL:0000255 ! eukaryotic cell intersection_of: CL:0000000 ! cell intersection_of: RO:0002162 NCBITaxon:4751 ! in taxon Fungi relationship: RO:0002162 NCBITaxon:4751 ! in taxon Fungi [Term] id: CL:0000522 name: obsolete spore def: "OBSOLETE: The reproductive structure of bacteria, fungi and cryptograms." [ISBN:08199377X] is_obsolete: true [Term] id: CL:0000523 name: mononuclear cytotrophoblast cell def: "A cell from the inner layer of the trophoblast of the early mammalian embryo that gives rise to the outer surface and villi of the chorion. Mononuclear crytoblasts fuse to give rise to a multinuclear cytotrophoblast." [GOC:tfm, ISBN:0323052908] subset: human_reference_atlas subset: human_subset subset: mouse_subset xref: FMA:83042 is_a: CL:0000351 ! trophoblast cell property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0000524 name: spheroplast def: "A cell, usually of bacteria or yeast, which has partially lost its cell wall." [MESH:D013104] synonym: "sphaeroplast" EXACT [] is_a: CL:0000371 ! protoplast [Term] id: CL:0000525 name: syncytiotrophoblast cell def: "A cell from the outer syncytial layer of the trophoblast of an early mammalian embryo, directly associated with the maternal blood supply. It secretes hCG in order to maintain progesterone secretion and sustain a pregnancy." [GOC:tfm, ISBN:0323052908] subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "plasmidotrophoblast cell" RELATED [] synonym: "syncytial trophoblast cell" EXACT [PMID:11787150] synonym: "syncytiotrophoblastic cell" EXACT [PMID:21733368] synonym: "syntrophoblast cell" RELATED [] xref: FMA:83043 is_a: CL:0000351 ! trophoblast cell is_a: CL:4052002 ! syncytial cell intersection_of: CL:0000351 ! trophoblast cell intersection_of: RO:0000053 PATO:0001908 ! has characteristic multinucleate relationship: BFO:0000050 UBERON:0000371 ! part of syncytiotrophoblast property_value: RO:0002175 NCBITaxon:9606 property_value: seeAlso "https://github.com/obophenotype/cell-ontology/issues/2100" xsd:string [Term] id: CL:0000526 name: afferent neuron def: "A neuron which conveys sensory information centrally from the periphery." [GOC:tfm, MESH:D009475] subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "input neuron" EXACT [] xref: FMA:87653 xref: ZFA:0009238 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000540 ! neuron property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "afferent neuron" xsd:string [Term] id: CL:0000527 name: efferent neuron def: "A neuron which sends impulses peripherally to activate muscles or secretory cells." [MESH:D009476] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "output neuron" EXACT [] xref: ZFA:0009239 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000540 ! neuron property_value: skos:prefLabel "efferent neuron" xsd:string [Term] id: CL:0000528 name: nitrergic neuron def: "A nerve cell where transmission is mediated by nitric oxide." [MESH:D026602] subset: human_subset subset: mouse_subset xref: FMA:84792 xref: ZFA:0009240 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000540 ! neuron [Term] id: CL:0000529 name: pigmented epithelial cell subset: cellxgene_subset subset: human_subset subset: mouse_subset xref: ZFA:0009241 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000710 ! neurecto-epithelial cell [Term] id: CL:0000530 name: primary neuron (sensu Teleostei) def: "A neuron that develops during the early segmentation stages in teleosts, before the neural tube is formed." [doi:10.1242/dev.108.1.121, PMID:1842357] xref: ZFA:0009242 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: BFO:0000002 is_a: CL:2000029 ! central nervous system neuron relationship: RO:0002100 UBERON:0002240 ! has soma location spinal cord relationship: RO:0002162 NCBITaxon:32443 {IAO:0000233="https://github.com/obophenotype/cell-ontology/pull/1950"} ! in taxon Teleostei [Term] id: CL:0000531 name: primary sensory neuron (sensu Teleostei) def: "A primary neuron (sensu Teleostei) that has a sensory function." [PMID:1842357] subset: cellxgene_subset is_a: CL:0000101 ! sensory neuron is_a: CL:0000530 ! primary neuron (sensu Teleostei) intersection_of: CL:0000101 ! sensory neuron intersection_of: CL:0000530 ! primary neuron (sensu Teleostei) [Term] id: CL:0000532 name: CAP motoneuron def: "A primary motor neuron with its soma in the caudal region of a spinal cord. The axon of this motoneuron exit the spinal cord from one single point and innervates the lateral surface of ventral axial muscles" [PMID:17971221, PMID:35431796] synonym: "cap cell" RELATED [PMID:17971221] synonym: "CaP motorneuron" EXACT [PMID:3746410] synonym: "caudal primary motor neuron" RELATED [PMID:18077593] xref: ZFA:0009243 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000533 ! primary motor neuron (sensu Teleostei) [Term] id: CL:0000533 name: primary motor neuron (sensu Teleostei) def: "A primary neuron (sensu Teleostei) that has a motor function." [PMID:1842357] xref: ZFA:0009244 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000530 ! primary neuron (sensu Teleostei) is_a: CL:0011001 ! spinal cord motor neuron [Term] id: CL:0000534 name: primary interneuron (sensu Teleostei) def: "A primary neuron (sensu Teleostei) that is neither a sensory neuron or a motor neuron." [PMID:1842357] xref: ZFA:0009245 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000530 ! primary neuron (sensu Teleostei) is_a: CL:0005000 ! spinal cord interneuron [Term] id: CL:0000535 name: secondary neuron (sensu Teleostei) def: "A neuron of teleosts that develops later than a primary neuron, typically during the larval stages." [doi:10.1242/dev.108.1.121, PMID:1842357] xref: ZFA:0009246 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:2000029 ! central nervous system neuron is_a: UBERON:0010313 ! neural crest-derived structure relationship: RO:0002100 UBERON:0002240 ! has soma location spinal cord relationship: RO:0002162 NCBITaxon:32443 {IAO:0000233="https://github.com/obophenotype/cell-ontology/pull/1950"} ! in taxon Teleostei [Term] id: CL:0000536 name: secondary motor neuron (sensu Teleostei) def: "A secondary neuron (sensu Teleostei) that has a motor function." [PMID:1842357] xref: ZFA:0009247 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000535 ! secondary neuron (sensu Teleostei) is_a: CL:0011001 ! spinal cord motor neuron intersection_of: CL:0000100 ! motor neuron intersection_of: CL:0000535 ! secondary neuron (sensu Teleostei) [Term] id: CL:0000537 name: obsolete antipodal cell def: "Obsolete. Use PO:0020093 from Plant Ontology instead. OBSOLETE, use term from plant ontology. A cell located at the chalazal end of the mature embryo sac in angiosperms." [ISBN:047125208] is_obsolete: true replaced_by: PO:0020093 [Term] id: CL:0000538 name: obsolete epidermal initial def: "Obsolete. Use PO:0000349 from Plant Ontology instead. A relatively unspecialized cell that will give rise to specialized cell types of the epidermis." [TAIR:lr] is_obsolete: true replaced_by: PO:0000349 [Term] id: CL:0000539 name: obsolete idioblast def: "OBSOLETE: A cell in a tissue that markedly differs in form, size, or contents from other cells in the same tissue." [ISBN:0471245208] is_obsolete: true [Term] id: CL:0000540 name: neuron def: "The basic cellular unit of nervous tissue. Each neuron consists of a body, an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the nervous system." [http://en.wikipedia.org/wiki/Neuron, MESH:D009474] comment: These cells are also reportedly CD4-negative and CD200-positive. They are also capable of producing CD40L and IFN-gamma. subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "nerve cell" EXACT [] xref: BTO:0000938 xref: CALOHA:TS-0683 xref: FBbt:00005106 {sssom:mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"} xref: FMA:54527 xref: VHOG:0001483 xref: WBbt:0003679 xref: ZFA:0009248 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000393 ! electrically responsive cell is_a: CL:0000404 ! electrically signaling cell is_a: CL:0002319 ! neural cell relationship: RO:0002215 GO:0019226 ! capable of transmission of nerve impulse property_value: foaf:depiction "https://www.swissbiopics.org/api/image/Neuron_cells.svg" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "neuron" xsd:string [Term] id: CL:0000541 name: melanoblast def: "A cell that originates from the neural crest and differentiates into a pigment cell." [GOC:tfm, SANBI:mhl] comment: Derived from UBERON:0002342 neural crest. subset: human_subset subset: mouse_subset xref: BTO:0003217 xref: FMA:83377 xref: ZFA:0009249 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0011026 ! progenitor cell relationship: RO:0002202 CL:0000333 ! develops from migratory neural crest cell [Term] id: CL:0000542 name: lymphocyte def: "A lymphocyte is a leukocyte commonly found in the blood and lymph that has the characteristics of a large nucleus, a neutral staining cytoplasm, and prominent heterochromatin." [GOC:add, ISBN:0683073696, ISBN:0781735149] comment: Editors note: consider adding taxon constraint to vertebrata (PMID:18025161) subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset xref: BTO:0000775 xref: CALOHA:TS-0583 xref: FMA:62863 xref: MESH:D008214 xref: VHOG:0001535 xref: ZFA:0009250 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000842 ! mononuclear leukocyte intersection_of: CL:0000738 ! leukocyte intersection_of: BFO:0000051 CL:0017500 ! has part neutrophillic cytoplasm intersection_of: BFO:0000051 GO:0000792 ! has part heterochromatin intersection_of: RO:0000053 PATO:0001407 ! has characteristic mononucleate intersection_of: RO:0000053 PATO:0040072 ! has characteristic high nuclear/cytoplasmic ratio disjoint_from: CL:0000766 ! myeloid leukocyte relationship: BFO:0000051 CL:0017500 ! has part neutrophillic cytoplasm relationship: BFO:0000051 GO:0000792 ! has part heterochromatin relationship: RO:0000053 PATO:0040072 ! has characteristic high nuclear/cytoplasmic ratio relationship: RO:0002202 CL:0000051 ! develops from common lymphoid progenitor property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0000543 name: obsolete sieve tube member def: "Obsolete. Use PO:0000289 from Plant Ontology instead. One of the series of cellular components of a sieve tube. It shows a more or less pronounced differentiation between sieve plates (wide pores) and lateral sieve areas (narrow pores). Also sieve tube element and the obsolete sieve tube segment." [ISBN:0471245208] synonym: "sieve tube element" EXACT [] is_obsolete: true replaced_by: PO:0000289 [Term] id: CL:0000544 name: slowly adapting mechanoreceptor cell subset: human_subset subset: mouse_subset is_a: CL:0000199 ! mechanoreceptor cell [Term] id: CL:0000545 name: T-helper 1 cell def: "A CD4-positive, alpha-beta T cell that has the phenotype T-bet-positive, CXCR3-positive, CCR6-negative, and is capable of producing interferon-gamma." [GO_REF:0000031, GOC:add, GOC:pam, GOC:tfm, PMID:19375293, PMID:20303875, PMID:22343568] comment: This cell type is compatible with the HIPC Lyoplate markers for 'Th1 CD4+ T cell', but its logical definition includes additional known characteristics of T-helper 1 T cells. subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "helper T cell type 1" EXACT [] synonym: "T helper cells type 1" EXACT [PMID:9419219] synonym: "T(H)-1 cell" EXACT [] synonym: "Th1 CD4+ T cell" EXACT [PMID:22343568] synonym: "Th1 cell" EXACT [] synonym: "Th1 T cell" EXACT [] synonym: "Th1 T lymphocyte" EXACT [] synonym: "Th1 T-cell" EXACT [] synonym: "Th1 T-lymphocyte" EXACT [] xref: BTO:0001678 xref: FMA:84382 is_a: CL:0000492 {is_inferred="true"} ! CD4-positive helper T cell intersection_of: CL:0000492 ! CD4-positive helper T cell intersection_of: BFO:0000051 PR:000001835 ! has part T-box transcription factor TBX21 intersection_of: CL:4030046 PR:000001202 ! lacks_plasma_membrane_part C-C chemokine receptor type 6 intersection_of: RO:0002104 PR:000001207 ! has plasma membrane part C-X-C chemokine receptor type 3 intersection_of: RO:0002215 GO:0032609 ! capable of type II interferon production relationship: BFO:0000051 PR:000001835 ! has part T-box transcription factor TBX21 relationship: CL:4030046 PR:000001202 ! lacks_plasma_membrane_part C-C chemokine receptor type 6 relationship: RO:0002104 PR:000001207 ! has plasma membrane part C-X-C chemokine receptor type 3 relationship: RO:0002215 GO:0032609 ! capable of type II interferon production property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0000546 name: T-helper 2 cell def: "A CD4-positive, alpha-beta T cell that has the phenotype GATA-3-positive, CXCR3-negative, CCR6-negative, and is capable of producing interleukin-4." [GO_REF:0000031, GOC:add, GOC:pam, GOC:tfm, PMID:19375293, PMID:20103781, PMID:22343568] comment: This cell type is compatible with the HIPC Lyoplate markers for 'non-Th1/Th17 CD4+ T cell' (see CL:0001051), but includes the additional necessary and sufficient conditions to allow classification as a T-helper 2 T cell. subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "helper T cell type 2" EXACT [] synonym: "T helper cells type 2" EXACT [PMID:9419219] synonym: "T(H)-2 cell" EXACT [] synonym: "Th2 cell" EXACT [] synonym: "Th2 T cell" EXACT [] synonym: "Th2 T lymphocyte" EXACT [] synonym: "Th2 T-cell" EXACT [] synonym: "Th2 T-lymphocyte" EXACT [] xref: BTO:0001679 xref: FMA:84385 xref: MESH:D018418 is_a: CL:0000492 {is_inferred="true"} ! CD4-positive helper T cell is_a: CL:0001051 ! CD4-positive, CXCR3-negative, CCR6-negative, alpha-beta T cell intersection_of: CL:0000492 ! CD4-positive helper T cell intersection_of: BFO:0000051 PR:000001941 ! has part trans-acting T-cell-specific transcription factor GATA-3 intersection_of: CL:4030046 PR:000001202 ! lacks_plasma_membrane_part C-C chemokine receptor type 6 intersection_of: CL:4030046 PR:000001207 ! lacks_plasma_membrane_part C-X-C chemokine receptor type 3 intersection_of: RO:0002215 GO:0032633 ! capable of interleukin-4 production relationship: BFO:0000051 PR:000001941 ! has part trans-acting T-cell-specific transcription factor GATA-3 relationship: RO:0002215 GO:0032633 ! capable of interleukin-4 production property_value: RO:0002175 NCBITaxon:9606 property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0000546" xsd:string {name="T-helper 2 cell on CELLxGENE CellGuide"} property_value: terms:description "T-helper 2 cells (Th2 cells) are a subset of CD4+ T lymphocytes, which play central roles in cell-mediated immunity. All T lymphocytes are uniquely characterized by the expression of a T-cell receptor (TCR) complex on their cell surface. Th2 cells express the CD4 co-receptor which enables the T-cell receptor to engage with antigen-presenting cells and perform their influential role in adaptive immune response.\nTh2 cells differentiate from naïve CD4+ T cells following TCR ligation and specific cytokine signaling. Th2 cell development and stabilization requires the master regulatory transcription factor GATA-3. Furthermore, IL-4-mediated activation of STAT6 is thought to play an important role in Th2 cell differentiation. \nThe primary function of Th2 cells is to coordinate the immune response against extracellular pathogens, particularly parasitic helminths. They achieve this primarily through the secretion of their signature cytokines – the interleukins IL-4, IL-5, and IL-13. For instance, IL-4 promotes the differentiation of B cells into plasma cells that produce immunoglobulin E (IgE), a class of antibodies that mediate the immune response to parasites and are involved in allergic reactions. IL-5 promotes the activation and survival of eosinophils, a type of white blood cell that is effective against certain parasites. IL-13 works alongside IL-4 but also influences mucus production in the respiratory tract, an important defense mechanism against parasites.\nDespite their critical roles in host defense, an overactive Th2 response can also lead to pathological outcomes such as allergy and asthma. These health issues are typically characterized by excessive IgE production, eosinophilic inflammation, and mucus hypersecretion, all hallmarks of a Th2 response. In these instances, the immune system reacts excessively to normally harmless substances like pollen, dust mites, or certain foods, with the Th2 cells driving this overreaction. As such, understanding the precise pathways and mechanisms through which Th2 cells operate not only provides insight into protective immune responses but also potential therapeutic targets for treating allergies and other related conditions.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1038/nri.2017.118", xref="DOI:10.1146/annurev-immunol-051116-052350", xref="DOI:10.3389/fimmu.2019.02318", xref="DOI:10.3389/fimmu.2022.974066"} [Term] id: CL:0000547 name: proerythroblast def: "An immature, nucleated erythrocyte occupying the stage of erythropoeisis that follows formation of erythroid progenitor cells. This cell is CD71-positive, has both a nucleus and a nucleolus, and lacks hematopoeitic lineage markers." [ISBN:0721601464, PMID:1638021] subset: blood_and_immune_upper_slim subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "pronormoblast" RELATED [] synonym: "rubriblast" EXACT [ISBN:0721601464] xref: FMA:83518 is_a: CL:0000764 {is_inferred="true"} ! erythroid lineage cell is_a: CL:0002242 ! nucleate cell intersection_of: CL:0000764 ! erythroid lineage cell intersection_of: BFO:0000051 CL:0017503 ! has part basophilic cytoplasm intersection_of: BFO:0000051 GO:0005730 ! has part nucleolus intersection_of: CL:4030046 PR:000001002 ! lacks_plasma_membrane_part CD19 molecule intersection_of: CL:4030046 PR:000001004 ! lacks_plasma_membrane_part CD4 molecule intersection_of: CL:4030046 PR:000001012 ! lacks_plasma_membrane_part integrin alpha-M intersection_of: CL:4030046 PR:000001020 ! lacks_plasma_membrane_part CD3 epsilon intersection_of: CL:4030046 PR:000001024 ! lacks_plasma_membrane_part neural cell adhesion molecule 1 intersection_of: CL:4030046 PR:000001083 ! lacks_plasma_membrane_part CD2 molecule intersection_of: CL:4030046 PR:000001084 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD8 alpha chain intersection_of: CL:4030046 PR:000001289 ! lacks_plasma_membrane_part membrane-spanning 4-domains subfamily A member 1 intersection_of: CL:4030046 PR:000001839 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD5 intersection_of: CL:4030046 PR:000001889 ! lacks_plasma_membrane_part CD14 molecule intersection_of: CL:4030046 PR:000002978 ! lacks_plasma_membrane_part lymphocyte antigen 6G intersection_of: RO:0000053 PATO:0002505 ! has characteristic nucleated intersection_of: RO:0000053 PATO:0040072 ! has characteristic high nuclear/cytoplasmic ratio intersection_of: RO:0002104 PR:000001945 ! has plasma membrane part transferrin receptor protein 1 relationship: BFO:0000051 CL:0017503 ! has part basophilic cytoplasm relationship: BFO:0000051 GO:0005730 ! has part nucleolus relationship: CL:4030046 PR:000001002 ! lacks_plasma_membrane_part CD19 molecule relationship: CL:4030046 PR:000001004 ! lacks_plasma_membrane_part CD4 molecule relationship: CL:4030046 PR:000001012 ! lacks_plasma_membrane_part integrin alpha-M relationship: CL:4030046 PR:000001020 ! lacks_plasma_membrane_part CD3 epsilon relationship: CL:4030046 PR:000001024 ! lacks_plasma_membrane_part neural cell adhesion molecule 1 relationship: CL:4030046 PR:000001083 ! lacks_plasma_membrane_part CD2 molecule relationship: CL:4030046 PR:000001084 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD8 alpha chain relationship: CL:4030046 PR:000001289 ! lacks_plasma_membrane_part membrane-spanning 4-domains subfamily A member 1 relationship: CL:4030046 PR:000001839 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD5 relationship: CL:4030046 PR:000001889 ! lacks_plasma_membrane_part CD14 molecule relationship: CL:4030046 PR:000002978 ! lacks_plasma_membrane_part lymphocyte antigen 6G relationship: RO:0000053 PATO:0040072 ! has characteristic high nuclear/cytoplasmic ratio relationship: RO:0002104 PR:000001945 ! has plasma membrane part transferrin receptor protein 1 relationship: RO:0002202 CL:0000038 ! develops from erythroid progenitor cell property_value: skos:prefLabel "proerythroblast" xsd:string [Term] id: CL:0000548 name: obsolete animal cell def: "OBSOLETE. A native cell that is part of some Metazoa." [] subset: ubprop:upper_level synonym: "metazoan cell" EXACT [] property_value: foaf:depiction "https://www.swissbiopics.org/api/image/Animal_cells.svg" xsd:anyURI property_value: IAO:0000233 https://github.com/obophenotype/cell-ontology/issues/2124 is_obsolete: true replaced_by: CL:0000000 [Term] id: CL:0000549 name: basophilic erythroblast def: "A nucleated immature erythrocyte, having cytoplasm generally similar to that of the earlier proerythroblast but sometimes even more basophilic, and usually regular in outline. The nucleus is still relatively large, but the chromatin strands are thicker and more deeply staining, giving a coarser appearance; the nucleoli have disappeared. This cell is CD71-positive and lacks hematopoeitic lineage markers." [GOC:tfm, ISBN:0721601464] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "basophilic normoblast" EXACT [ISBN:0721601464] synonym: "early erythroblast" EXACT [ISBN:0721601464] synonym: "early normoblast" EXACT [ISBN:0721601464] synonym: "prorubricyte" EXACT [ISBN:0721601464] xref: FMA:83505 xref: ZFA:0005236 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000765 {is_inferred="true"} ! erythroblast intersection_of: CL:0000765 ! erythroblast intersection_of: BFO:0000051 CL:0017503 ! has part basophilic cytoplasm intersection_of: BFO:0000051 GO:0000792 ! has part heterochromatin intersection_of: RO:0002104 PR:000001945 ! has plasma membrane part transferrin receptor protein 1 relationship: BFO:0000051 CL:0017503 ! has part basophilic cytoplasm relationship: BFO:0000051 GO:0000792 ! has part heterochromatin relationship: RO:0002104 PR:000001945 ! has plasma membrane part transferrin receptor protein 1 property_value: skos:prefLabel "basophilic erythroblast" xsd:string [Term] id: CL:0000550 name: polychromatophilic erythroblast def: "A nucleated, immature erythrocyte in which the nucleus occupies a relatively smaller part of the cell than in its precursor, the basophilic erythroblast. The cytoplasm is beginning to acquire hemoglobin and thus is no longer a purely basophilic, but takes on acidophilic aspects, which becomes progressively more marked as the cell matures. The chromatin of the nucleus is arranged in coarse, deeply staining clumps. This cell is CD71-positive and lacks hematopoeitic lineage markers." [ISBN:0721601464] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "intermediate erythroblast" EXACT [ISBN:0721601464] synonym: "intermediate normoblast" EXACT [ISBN:0721601464] synonym: "polychromatic erythroblast" EXACT [ISBN:0721601464] synonym: "polychromatic normoblast" EXACT [ISBN:0721601464] synonym: "polychromatophilic normoblast" EXACT [ISBN:0721601464] synonym: "rubricyte" EXACT [ISBN:0721601464] xref: FMA:83506 xref: ZFA:0005241 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000765 {is_inferred="true"} ! erythroblast intersection_of: CL:0000765 ! erythroblast intersection_of: BFO:0000051 CL:0017504 ! has part polychromatophilic cytoplasm intersection_of: BFO:0000051 GO:0000792 ! has part heterochromatin intersection_of: RO:0002104 PR:000001945 ! has plasma membrane part transferrin receptor protein 1 relationship: BFO:0000051 CL:0017504 ! has part polychromatophilic cytoplasm relationship: BFO:0000051 GO:0000792 ! has part heterochromatin relationship: RO:0002104 PR:000001945 ! has plasma membrane part transferrin receptor protein 1 relationship: RO:0002202 CL:0000549 ! develops from basophilic erythroblast property_value: skos:prefLabel "polychromatophilic erythroblast" xsd:string [Term] id: CL:0000551 name: unimodal nocireceptor subset: human_subset subset: mouse_subset is_a: CL:0000198 ! pain receptor cell [Term] id: CL:0000552 name: orthochromatic erythroblast def: "The final stage of the nucleated, immature erythrocyte, before nuclear loss. Typically the cytoplasm is described as acidophilic, but it still shows a faint polychromatic tint. The nucleus is small and initially may still have coarse, clumped chromatin, as in its precursor, the polychromatophilic erythroblast, but ultimately it becomes pyknotic, and appears as a deeply staining, blue-black, homogeneous structureless mass. The nucleus is often eccentric and sometimes lobulated." [ISBN:0721601464] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "acidophilic erythroblast" EXACT [ISBN:0721601464] synonym: "eosinophilic erythroblast" EXACT [ISBN:0721601464] synonym: "late erythoblast" EXACT [] synonym: "orthochromatic normoblast" EXACT [ISBN:0721601464] synonym: "pyknotic eto enrythroblast" EXACT [ISBN:0721601464] xref: FMA:84646 is_a: CL:0000765 {is_inferred="true"} ! erythroblast intersection_of: CL:0000765 ! erythroblast intersection_of: BFO:0000051 CL:0017502 ! has part acidophilic cytoplasm intersection_of: RO:0000056 GO:0030263 ! participates in apoptotic chromosome condensation relationship: BFO:0000051 CL:0017502 ! has part acidophilic cytoplasm relationship: RO:0000056 GO:0030263 ! participates in apoptotic chromosome condensation relationship: RO:0002202 CL:0000550 ! develops from polychromatophilic erythroblast property_value: skos:prefLabel "orthochromatic erythroblast" xsd:string [Term] id: CL:0000553 name: megakaryocyte progenitor cell def: "The earliest cytologically identifiable precursor in the thrombocytic series. This cell is capable of endomitosis and lacks expression of hematopoieitic lineage markers (lin-negative)." [GOC:dsd, GOC:tfm, ISBN:0721601464] comment: Lineage negative is described here as CD2-negative, CD3-negative, CD4-negative, CD5-negative, CD8a-negative, CD14-negative, CD19-negative, CD20-negative, CD56-negative, Ly6g-negative, and Ter119-negative. subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "CFU-Meg" EXACT [PMID:11722431, PMID:12482498] synonym: "colony-forming unit-megakaryocyte" EXACT [] synonym: "Meg-CFC" EXACT [PMCID:PMC1794060] synonym: "megacaryoblast" EXACT [] synonym: "megacaryocyte progenitor cell" EXACT [] synonym: "megakaryoblast" EXACT [] synonym: "megakaryocytic progenitor cell" EXACT [PMID:12482498] synonym: "MkP" EXACT [PMID:21116988] synonym: "promegacaryocyte" RELATED [] synonym: "promegakaryocyte" RELATED [] xref: BTO:0001164 xref: CALOHA:TS-0610 xref: FMA:84235 xref: MESH:D055016 is_a: CL:0000763 ! myeloid cell is_a: CL:0000839 {is_inferred="true"} ! myeloid lineage restricted progenitor cell intersection_of: CL:0000839 ! myeloid lineage restricted progenitor cell intersection_of: CL:4030046 PR:000001002 ! lacks_plasma_membrane_part CD19 molecule intersection_of: CL:4030046 PR:000001004 ! lacks_plasma_membrane_part CD4 molecule intersection_of: CL:4030046 PR:000001012 ! lacks_plasma_membrane_part integrin alpha-M intersection_of: CL:4030046 PR:000001020 ! lacks_plasma_membrane_part CD3 epsilon intersection_of: CL:4030046 PR:000001024 ! lacks_plasma_membrane_part neural cell adhesion molecule 1 intersection_of: CL:4030046 PR:000001083 ! lacks_plasma_membrane_part CD2 molecule intersection_of: CL:4030046 PR:000001084 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD8 alpha chain intersection_of: CL:4030046 PR:000001289 ! lacks_plasma_membrane_part membrane-spanning 4-domains subfamily A member 1 intersection_of: CL:4030046 PR:000001839 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD5 intersection_of: CL:4030046 PR:000001889 ! lacks_plasma_membrane_part CD14 molecule intersection_of: CL:4030046 PR:000002978 ! lacks_plasma_membrane_part lymphocyte antigen 6G intersection_of: CL:4030046 PR:000002981 ! lacks_plasma_membrane_part lymphocyte antigen 76 (mouse) intersection_of: RO:0002215 GO:0007113 ! capable of endomitotic cell cycle intersection_of: RO:0002215 GO:0030219 ! capable of megakaryocyte differentiation relationship: CL:4030046 PR:000001002 ! lacks_plasma_membrane_part CD19 molecule relationship: CL:4030046 PR:000001004 ! lacks_plasma_membrane_part CD4 molecule relationship: CL:4030046 PR:000001012 ! lacks_plasma_membrane_part integrin alpha-M relationship: CL:4030046 PR:000001020 ! lacks_plasma_membrane_part CD3 epsilon relationship: CL:4030046 PR:000001024 ! lacks_plasma_membrane_part neural cell adhesion molecule 1 relationship: CL:4030046 PR:000001083 ! lacks_plasma_membrane_part CD2 molecule relationship: CL:4030046 PR:000001084 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD8 alpha chain relationship: CL:4030046 PR:000001289 ! lacks_plasma_membrane_part membrane-spanning 4-domains subfamily A member 1 relationship: CL:4030046 PR:000001839 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD5 relationship: CL:4030046 PR:000001889 ! lacks_plasma_membrane_part CD14 molecule relationship: CL:4030046 PR:000002978 ! lacks_plasma_membrane_part lymphocyte antigen 6G relationship: CL:4030046 PR:000002981 ! lacks_plasma_membrane_part lymphocyte antigen 76 (mouse) relationship: RO:0002202 CL:0000050 ! develops from megakaryocyte-erythroid progenitor cell relationship: RO:0002215 GO:0007113 ! capable of endomitotic cell cycle relationship: RO:0002215 GO:0030219 ! capable of megakaryocyte differentiation property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0000554 name: gastrin stimulating hormone secreting cell def: "A peptide hormone secreting cell that secretes gastrin stimulating hormone." [GOC:tfm] subset: human_subset subset: mouse_subset is_a: CL:0000167 ! peptide hormone secreting cell [Term] id: CL:0000555 name: obsolete neuronal brush cell is_obsolete: true replaced_by: CL:4023161 [Term] id: CL:0000556 name: megakaryocyte def: "A large hematopoietic cell (50 to 100 micron) with a lobated nucleus. Once mature, this cell undergoes multiple rounds of endomitosis and cytoplasmic restructuring to allow platelet formation and release." [http://en.wikipedia.org/wiki/Megakaryocyte, ISBN:0721601464, MESH:D008533, PMID:31043076] comment: Megakaryocytes are reportedly CD181-positive and CD182-positive. subset: blood_and_immune_upper_slim subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "megacaryocyte" EXACT [] synonym: "megalocaryocyte" EXACT [] synonym: "megalokaryocyte" EXACT [] xref: BTO:0000843 xref: CALOHA:TS-0611 xref: FMA:83555 is_a: CL:0000763 {is_inferred="true"} ! myeloid cell disjoint_from: CL:0000764 ! erythroid lineage cell relationship: RO:0000053 PATO:0001393 ! has characteristic euploid relationship: RO:0002202 CL:0000553 ! develops from megakaryocyte progenitor cell property_value: RO:0002175 NCBITaxon:9606 property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0000556" xsd:string {name="megakaryocyte on CELLxGENE CellGuide"} property_value: terms:description "A megakaryocyte is a large, unique, and complex cell type found primarily in the bone marrow, the spongy, semi-solid tissue located in the medullary cavities of certain bones. The term ‘megakaryocyte’ is derived from the Greek 'mega', meaning great, and 'karyon', referring to the nucleus. Megakaryocytes are characterized by their large size, typically with a diameter of 50-100 µm in humans, and the presence of a multilobulated nucleus; they are the largest hematopoietic cells in the bone marrow but also the rarest cells. \nThe primary function of a megakaryocyte is the production of platelets, also known as thrombocytes. Platelets are small, anucleate cell fragments that play a crucial role in the process of hemostasis, the arrest of blood loss from a damaged blood vessel. The process begins when the megakaryocyte extends long, branching processes called proplatelets, into the sinusoidal blood vessels present in the bone marrow. These proplatelets then fragment into the discoid structures recognized as platelets. Each megakaryocyte can produce thousands of platelets during its lifespan. \nApart from platelet production, megakaryocytes are involved in several other functions. They express immune-sensing receptors such as Fc-γ receptor and Toll-like receptors and produce factors such as platelet factor 4 and platelet-derived growth factor that can stimulate the immune system. Also, in certain pathological conditions, megakaryocytes release TGF-β and PDGF and contribute to bone marrow fibrosis, a condition characterized by excessive accumulation of fibrous tissue in the bone marrow leading to anemia. Recent studies have also highlighted the role of megakaryocytes in regulating hematopoiesis, the process of blood cell production. They can influence the bone marrow microenvironment and control the behavior of hematopoietic stem cells, the progenitors of all types of blood cells.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1002/JLB.MR0718-261RR", xref="DOI:10.1083/jcb.201304054", xref="DOI:10.1161/ATVBAHA.119.312129", xref="DOI:10.1186/s12967-023-04393-z", xref="https://www.sciencedirect.com/topics/agricultural-and-biological-sciences/megakaryocyte"} [Term] id: CL:0000557 name: granulocyte monocyte progenitor cell def: "A hematopoietic progenitor cell that is committed to the granulocyte and monocyte lineages. These cells are CD123-positive, and do not express Gata1 or Gata2 but do express C/EBPa, and Pu.1." [GO_REF:0000031, GOC:amm, GOC:dsd, GOC:tfm, http://en.wikipedia.org/wiki/CFU-GM, http://www.copewithcytokines.de, ISBN:0721601464, MESH:D055014, PMCID:PMC2213186, PMCID:PMC548021, PMID:16551251, PMID:16647566] comment: Originally described in the dendritic cell ontology (DC_CL:0000042)(PMID:19243617). GMPs are reportedly CD16-positive, CD32-positive, CD34-positive, CD38-positive, CD45RA-positive, CD110-negative, CD117-positive, CD123-positive, and SCA1-negative. subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "CFU-C , Colony forming unit in culture" BROAD [http://www.copewithcytokines.de] synonym: "CFU-GM" RELATED OMO:0003000 [ISBN:0721601464, PMCID:PMC2213186, PMCID:PMC548021] synonym: "colony forming unit granulocyte macrophage" EXACT [ISBN:0721601464, PMCID:PMC2213186, PMCID:PMC548021] synonym: "GMP" RELATED OMO:0003000 [ISBN:0721601464, PMCID:PMC2213186, PMCID:PMC548021] synonym: "granulocyte-macrophage progenitor" EXACT [ISBN:0721601464, PMCID:PMC2213186, PMCID:PMC548021] synonym: "granulocyte/monocyte precursor" EXACT [] synonym: "granulocyte/monocyte progenitor" EXACT [] xref: ZFA:0009251 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000763 ! myeloid cell is_a: CL:0001012 ! CD7-negative lymphoid progenitor OR granulocyte monocyte progenitor is_a: CL:1001610 ! bone marrow hematopoietic cell intersection_of: CL:0002032 ! hematopoietic oligopotent progenitor cell intersection_of: BFO:0000050 UBERON:0002371 ! part of bone marrow intersection_of: BFO:0000051 PR:000001944 ! has part transcription factor PU.1 intersection_of: BFO:0000051 PR:000005307 ! has part CCAAT/enhancer-binding protein alpha intersection_of: CL:4030045 PR:000007857 ! lacks_part erythroid transcription factor intersection_of: CL:4030045 PR:000007858 ! lacks_part endothelial transcription factor GATA-2 intersection_of: RO:0002104 PR:000001865 ! has plasma membrane part interleukin-3 receptor class 2 alpha chain intersection_of: RO:0002215 GO:0030225 ! capable of macrophage differentiation intersection_of: RO:0002215 GO:0030851 ! capable of granulocyte differentiation relationship: BFO:0000051 PR:000001944 ! has part transcription factor PU.1 relationship: BFO:0000051 PR:000005307 ! has part CCAAT/enhancer-binding protein alpha relationship: CL:4030045 PR:000007857 ! lacks_part erythroid transcription factor relationship: CL:4030045 PR:000007858 ! lacks_part endothelial transcription factor GATA-2 relationship: RO:0002104 PR:000001865 ! has plasma membrane part interleukin-3 receptor class 2 alpha chain relationship: RO:0002215 GO:0030225 ! capable of macrophage differentiation relationship: RO:0002215 GO:0030851 ! capable of granulocyte differentiation property_value: RO:0002175 NCBITaxon:9606 property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0000557" xsd:string {name="granulocyte monocyte progenitor cell on CELLxGENE CellGuide"} property_value: terms:description "Granulocyte monocyte progenitor cells (GMP cells), originating from hematopoietic stem cells in the bone marrow, are a critical intermediate in myeloid cell development. Positioned at a key differentiation juncture, these cells exhibit bidirectional potential, giving rise to both granulocyte and monocyte lineages.\nTheir primary role is to generate mature granulocytes and monocytes, essential components of the body's innate immunity and inflammatory responses. Granulocytes, such as neutrophils, eosinophils, and basophils, contribute to the first line of defense against infections by migrating to the infection site and phagocytosing pathogens. Monocytes can differentiate into macrophages or dendritic cells, playing diverse roles in immune responses.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1016/j.immuni.2017.10.021", xref="DOI:10.1146/annurev-immunol-081022113627", xref="DOI:10.1186/2050-7771-2-1"} [Term] id: CL:0000558 name: reticulocyte def: "An immature erythrocyte that changes the protein composition of its plasma membrane by exosome formation and extrusion. The types of protein removed differ between species though removal of the transferrin receptor is apparent in mammals and birds." [GOC:add, GOC:tfm, PMID:15946868, PMID:2037622] subset: blood_and_immune_upper_slim subset: cellxgene_subset subset: human_subset subset: mouse_subset xref: BTO:0001173 xref: CALOHA:TS-0864 xref: MESH:D012156 xref: ZFA:0009252 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000764 {is_inferred="true"} ! erythroid lineage cell intersection_of: CL:0000764 ! erythroid lineage cell intersection_of: CL:4030046 PR:000001002 ! lacks_plasma_membrane_part CD19 molecule intersection_of: CL:4030046 PR:000001004 ! lacks_plasma_membrane_part CD4 molecule intersection_of: CL:4030046 PR:000001012 ! lacks_plasma_membrane_part integrin alpha-M intersection_of: CL:4030046 PR:000001020 ! lacks_plasma_membrane_part CD3 epsilon intersection_of: CL:4030046 PR:000001024 ! lacks_plasma_membrane_part neural cell adhesion molecule 1 intersection_of: CL:4030046 PR:000001083 ! lacks_plasma_membrane_part CD2 molecule intersection_of: CL:4030046 PR:000001084 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD8 alpha chain intersection_of: CL:4030046 PR:000001289 ! lacks_plasma_membrane_part membrane-spanning 4-domains subfamily A member 1 intersection_of: CL:4030046 PR:000001839 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD5 intersection_of: CL:4030046 PR:000001889 ! lacks_plasma_membrane_part CD14 molecule intersection_of: CL:4030046 PR:000002978 ! lacks_plasma_membrane_part lymphocyte antigen 6G intersection_of: RO:0002104 PR:000001945 ! has plasma membrane part transferrin receptor protein 1 intersection_of: RO:0002215 GO:0071971 ! capable of extracellular exosome assembly relationship: CL:4030046 PR:000001002 ! lacks_plasma_membrane_part CD19 molecule relationship: CL:4030046 PR:000001004 ! lacks_plasma_membrane_part CD4 molecule relationship: CL:4030046 PR:000001012 ! lacks_plasma_membrane_part integrin alpha-M relationship: CL:4030046 PR:000001020 ! lacks_plasma_membrane_part CD3 epsilon relationship: CL:4030046 PR:000001024 ! lacks_plasma_membrane_part neural cell adhesion molecule 1 relationship: CL:4030046 PR:000001083 ! lacks_plasma_membrane_part CD2 molecule relationship: CL:4030046 PR:000001084 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD8 alpha chain relationship: CL:4030046 PR:000001289 ! lacks_plasma_membrane_part membrane-spanning 4-domains subfamily A member 1 relationship: CL:4030046 PR:000001839 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD5 relationship: CL:4030046 PR:000001889 ! lacks_plasma_membrane_part CD14 molecule relationship: CL:4030046 PR:000002978 ! lacks_plasma_membrane_part lymphocyte antigen 6G relationship: RO:0002104 PR:000001945 ! has plasma membrane part transferrin receptor protein 1 relationship: RO:0002202 CL:0000552 ! develops from orthochromatic erythroblast relationship: RO:0002215 GO:0071971 ! capable of extracellular exosome assembly property_value: skos:prefLabel "reticulocyte" xsd:string [Term] id: CL:0000559 name: promonocyte def: "A precursor in the monocytic series, being a cell intermediate in development between the monoblast and monocyte. This cell is CD11b-positive and has fine azurophil granules." [GOC:tfm, ISBN:0721601464] comment: Morphology: Mononuclear cell, diameter 14-18 _M, fine azurophilic granules; markers: CD11b (shared with many other myeloid cells); location: Adult: bone marrow; Fetal: Liver, Yolk Sac; role or process: hematopoiesis, monocyte development; lineage: hematopoietic, myeloid. subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset xref: BTO:0004657 xref: FMA:83551 xref: ZFA:0009253 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000763 ! myeloid cell is_a: CL:0002194 {is_inferred="true"} ! monopoietic cell intersection_of: CL:0002194 ! monopoietic cell intersection_of: BFO:0000051 GO:0042582 ! has part azurophil granule intersection_of: RO:0002104 PR:000001012 ! has plasma membrane part integrin alpha-M intersection_of: RO:0002215 GO:0030224 ! capable of monocyte differentiation relationship: BFO:0000051 GO:0042582 ! has part azurophil granule relationship: RO:0002104 PR:000001012 ! has plasma membrane part integrin alpha-M relationship: RO:0002202 CL:0000040 ! develops from monoblast property_value: RO:0002175 NCBITaxon:9606 property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0000559" xsd:string {name="promonocyte on CELLxGENE CellGuide"} property_value: terms:description "Promonocytes are precursor cells in the mononuclear phagocyte system, which includes the progenitors in the bone marrow, circulating monocytes and macrophages in various tissues. During monocytopoiesis, promonocytes form after monoblasts differentiate, and precede the development of monocytes and macrophages, which play an integral role in the immune system.\nPromonocytes are large, often round cells with a high nucleus to cytoplasm ratio. Their cytoplasm is laden with small azurophilic granules, and they are similar in appearance to myelocytes and metamyelocytes. \nThe maturation into monocytes is the key function of promonocytes. Once matured, they navigate their way to the bloodstream and their primary role comes into effect. Monocytes circulate in the blood for a few days before migrating to tissues to become either macrophages or dendritic cells. These cells then proceed to ingest pathogens like bacteria and viruses, helping to keep the body healthy. Thus, promonocytes play a central role in the immune system by paving the way for the development of cells that fight off toxins and attacks.\nBeyond their immune response role through differentiation, promonocytes may participate in processes such as wound healing and inflammation regulation. Defects or disruptions in promonocyte function have been linked to health disorders, including monocytic-lineage leukemias such as chronic myelomonocytic leukemia (CMML), although it is worth noting that morphologic distinction between promonocytes and other monocytic cells of various differentiation levels is difficult.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1016/B978-0-323-35762-3.00027-5", xref="DOI:10.1111/ijlh.13212", xref="DOI:10.1182/blood.2022015850", xref="https://www.sciencedirect.com/topics/agricultural-and-biological-sciences/promonocyte"} [Term] id: CL:0000560 name: band form neutrophil def: "A late neutrophilic metamyelocyte in which the nucleus is indented to more than half the distance to the farthest nuclear margin but in no area being condensed to a single filament. The nucleus is in the form of a curved or coiled band, not having acquired the typical multilobar shape of the mature neutrophil. These cells are fMLP receptor-positive, CD11b-positive, CD35-negative, and CD49d-negative." [GOC:add, GOC:dsd, GOC:tfm, http://www.cap.org, ISBN:0721601464, PMID:10618520, PMID:12560239, PMID:15514007] comment: Found in the Band 1 fraction. subset: human_subset subset: mouse_subset synonym: "band" BROAD [] synonym: "band cell" BROAD [] synonym: "band form" BROAD [] synonym: "rod neutrophil" EXACT [] synonym: "stab cell" BROAD [] xref: ZFA:0009254 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000096 {is_inferred="true"} ! mature neutrophil intersection_of: CL:0000096 ! mature neutrophil intersection_of: BFO:0000051 CL:0017506 ! has part banded nucleus intersection_of: BFO:0000051 PR:000001944 ! has part transcription factor PU.1 intersection_of: BFO:0000051 PR:000005307 ! has part CCAAT/enhancer-binding protein alpha intersection_of: BFO:0000051 PR:000007597 ! has part protein c-Fos intersection_of: CL:4030045 PR:000009978 ! lacks_part lactotransferrin intersection_of: CL:4030045 PR:000010799 ! lacks_part myb proto-oncogene protein intersection_of: CL:4030046 PR:000009129 ! lacks_plasma_membrane_part integrin alpha-4 intersection_of: CL:4030046 PR:000010543 ! lacks_plasma_membrane_part myeloperoxidase intersection_of: RO:0002104 PR:000001012 ! has plasma membrane part integrin alpha-M intersection_of: RO:0002104 PR:000001337 ! has plasma membrane part complement receptor type 1 intersection_of: RO:0002104 PR:000001580 ! has plasma membrane part fMet-Leu-Phe receptor relationship: BFO:0000051 CL:0017506 ! has part banded nucleus relationship: BFO:0000051 PR:000005307 ! has part CCAAT/enhancer-binding protein alpha relationship: CL:4030046 PR:000009129 ! lacks_plasma_membrane_part integrin alpha-4 relationship: CL:4030046 PR:000010543 ! lacks_plasma_membrane_part myeloperoxidase relationship: RO:0002104 PR:000001337 ! has plasma membrane part complement receptor type 1 relationship: RO:0002104 PR:000001580 ! has plasma membrane part fMet-Leu-Phe receptor relationship: RO:0002202 CL:0000582 ! develops from neutrophilic metamyelocyte [Term] id: CL:0000561 name: amacrine cell def: "Interneuron of the vertebrate retina. They integrate, modulate, and interpose a temporal domain in the visual message presented to the retinal ganglion cells, with which they synapse in the inner plexiform layer. They lack large axons." [GOC:tfm, MESH:D025042, WikipediaVersioned:Amacrine_cell&oldid=1023572246] subset: cellxgene_subset subset: eye_upper_slim subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "AC" RELATED OMO:0003000 [doi:10.1038/s41598-020-66092-9] synonym: "ACs" RELATED OMO:0003004 [doi:10.1038/s41598-020-66092-9] synonym: "amacrine neuron" EXACT [] xref: BTO:0004044 xref: FMA:67766 xref: ZFA:0009255 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: BFO:0000002 is_a: CL:0000099 ! interneuron is_a: CL:0009004 ! retinal cell relationship: BFO:0000050 UBERON:0000966 ! part of retina relationship: RO:0002120 CL:0000740 ! synapsed to retinal ganglion cell property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0000562 name: nucleate erythrocyte def: "An erythrocyte having a nucleus." [GOC:add, GOc:tfm] subset: human_subset subset: mouse_subset synonym: "RBC" BROAD [] synonym: "red blood cell" BROAD [] xref: ZFA:0009256 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000232 {is_inferred="true"} ! erythrocyte is_a: CL:0002242 ! nucleate cell intersection_of: CL:0000232 ! erythrocyte intersection_of: RO:0000053 PATO:0002505 ! has characteristic nucleated relationship: RO:0002202 CL:0002421 ! develops from nucleated reticulocyte [Term] id: CL:0000563 name: endospore def: "A rounded, inactive form that certain bacteria assume under conditions of extreme temperature, dryness, or lack of food. The bacterium develops a waterproof cell wall that protects it from being dried out or damaged." [GOC:tfm, ISBN:0618947256] synonym: "bacterial spore" EXACT [] xref: BTO:0002779 is_a: CL:0000520 ! prokaryotic cell [Term] id: CL:0000564 name: neutrophilic promyelocyte def: "A promyelocyte committed to the neutrophil lineage. This cell type is GATA-1-positive, C/EBPa-positive, AML-1-positive, MPO-positive, has low expression of PU.1 transcription factor and lacks lactotransferrin expression." [GOC:add, GOC:dsd, GOC:tfm, ISBN:0721601464, PMID:12560239, PMID:15514007] comment: These cells are CD11b-negative, CD15-positive, CD16-negative, CD49d-positive, CD68-positive, CD35-negative, and fMLP receptor-negative. They are found in the Band 3 fraction. subset: human_subset subset: mouse_subset synonym: "neutrophilic premyelocyte" EXACT [] synonym: "neutrophilic progranulocyte" EXACT [] xref: FMA:84196 xref: ZFA:0009257 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000834 ! neutrophil progenitor cell is_a: CL:0000836 {is_inferred="true"} ! promyelocyte intersection_of: CL:0000836 ! promyelocyte intersection_of: BFO:0000051 PR:000001944 ! has part transcription factor PU.1 intersection_of: BFO:0000051 PR:000005307 ! has part CCAAT/enhancer-binding protein alpha intersection_of: BFO:0000051 PR:000007857 ! has part erythroid transcription factor intersection_of: BFO:0000051 PR:000010543 ! has part myeloperoxidase intersection_of: BFO:0000051 PR:000014362 ! has part runt-related transcription factor 1 intersection_of: CL:4030045 PR:000009978 ! lacks_part lactotransferrin intersection_of: RO:0002215 GO:0030223 ! capable of neutrophil differentiation relationship: BFO:0000051 PR:000001944 ! has part transcription factor PU.1 relationship: BFO:0000051 PR:000005307 ! has part CCAAT/enhancer-binding protein alpha relationship: BFO:0000051 PR:000007857 ! has part erythroid transcription factor relationship: BFO:0000051 PR:000010543 ! has part myeloperoxidase relationship: BFO:0000051 PR:000014362 ! has part runt-related transcription factor 1 relationship: CL:4030045 PR:000009978 ! lacks_part lactotransferrin relationship: RO:0002202 CL:0000042 ! develops from neutrophilic myeloblast [Term] id: CL:0000565 name: fat body cell def: "A cell found in fat bodies whose primary function is intermediary metabolism." [FB:ma] subset: human_subset subset: mouse_subset is_a: CL:0000325 ! stuff accumulating cell [Term] id: CL:0000566 name: angioblastic mesenchymal cell def: "A mesenchymal stem cell capable of developing into blood vessel endothelium." [GOC:dsd, GOC:tfm, PMID:12768659] comment: These cells are reportedly CD31-positive, CD34-positive, CD144-positive, CD309-positive, and TAL1-positive. subset: human_subset subset: mouse_subset synonym: "angioblast" EXACT [] synonym: "chondroplast" EXACT [] xref: ZFA:0009258 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000134 {is_inferred="true"} ! mesenchymal stem cell is_a: CL:0011026 ! progenitor cell intersection_of: CL:0000134 ! mesenchymal stem cell intersection_of: RO:0002104 PR:000001444 ! has plasma membrane part cadherin-5 intersection_of: RO:0002104 PR:000002112 ! has plasma membrane part vascular endothelial growth factor receptor 2 intersection_of: RO:0002104 PR:000016043 ! has plasma membrane part T-cell acute lymphocytic leukemia protein 1 relationship: RO:0002104 PR:000001444 ! has plasma membrane part cadherin-5 relationship: RO:0002104 PR:000002112 ! has plasma membrane part vascular endothelial growth factor receptor 2 relationship: RO:0002104 PR:000016043 ! has plasma membrane part T-cell acute lymphocytic leukemia protein 1 relationship: RO:0002202 CL:0000134 ! develops from mesenchymal stem cell property_value: skos:prefLabel "angioblastic mesenchymal cell" xsd:string [Term] id: CL:0000567 name: polymodal nocireceptor subset: human_subset subset: mouse_subset is_a: CL:0000198 ! pain receptor cell [Term] id: CL:0000568 name: amine precursor uptake and decarboxylation cell def: "A cell that originates in the neural crest, that has certain cytochemical and ultrastructural characteristics and is found scattered throughout the body; types include melanocytes, the cells of the chromaffin system, and cells in the hypothalamus, hypophysis, thyroid, parathyroids, lungs, gastrointestinal tract, and pancreas. This cell type concentrates the amino acid precursors of certain amines and decarboxylate them, forming amines that function as regulators and neurotransmitters. This cell type produces substances such as epinephrine, norepinephrine, dopamine, serotonin, enkephalin, somatostatin, neurotensin, and substance P, the actions of which may affect contiguous cells, nearby groups of cells, or distant cells, thus functioning as local or systemic hormones. The name is an acronym for amine precursor uptake and decarboxylation cell." [GOC:tfm, ISBN:0721662544] subset: human_subset subset: mouse_subset synonym: "APUD cell" EXACT [] xref: BTO:0003866 xref: FMA:83114 xref: MESH:D001078 is_a: CL:0000165 ! neuroendocrine cell property_value: skos:prefLabel "amine precursor uptake and decarboxylation cell" xsd:string [Term] id: CL:0000569 name: cardiac mesenchymal cell def: "A mesenchymal cell found in the developing heart and that develops into some part of the heart. These cells derive from intra- and extra-cardiac sources, including the endocardium, epicardium, neural crest, and second heart field." [PMID:18816864] subset: cellxgene_subset subset: human_subset subset: mouse_subset xref: ZFA:0009259 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0008019 ! mesenchymal cell is_a: CL:2000073 ! migratory cardiac neural crest cell intersection_of: CL:0008019 ! mesenchymal cell intersection_of: RO:0002203 CL:0002494 ! develops into cardiocyte relationship: RO:0002203 CL:0002494 ! develops into cardiocyte [Term] id: CL:0000570 name: parafollicular cell def: "A neuroepithelial cells that occurs singly or in small groups, close to the outer follicular borders but within the follicular basement membrane of the thyroid. This cell expresses a form of the neural cell adhesion molecule (N-CAM) on its surface and secretes calcitonin and serotonin (5-hydroxytryptamine)." [GOC:tfm, ISBN:0517223651] subset: human_subset subset: mouse_subset synonym: "C cell" EXACT [] synonym: "C cell of thyroid gland" EXACT [FMA:68653] synonym: "clear cell of thyroid gland" EXACT [FMA:68653] synonym: "parafollicular cell of thyroid gland" EXACT [FMA:68653] synonym: "thyroid parafollicular cell" EXACT [FMA:68653] xref: FMA:68653 xref: SCTID:176770005 xref: ZFA:0009260 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000163 ! endocrine cell is_a: CL:0000443 ! calcitonin secreting cell is_a: CL:0000458 ! serotonin secreting cell is_a: CL:0000710 {is_inferred="true"} ! neurecto-epithelial cell is_a: CL:0002257 ! epithelial cell of thyroid gland relationship: BFO:0000050 UBERON:0001747 ! part of parenchyma of thyroid gland relationship: RO:0002104 PR:000001024 ! has plasma membrane part neural cell adhesion molecule 1 relationship: RO:0002202 CL:0000333 ! develops from migratory neural crest cell [Term] id: CL:0000571 name: leucophore def: "A pigment cell derived from the neural crest. Contains uric acid or other purine crystals deposited in stacks called leucosomes. The crystals reflect light and this gives a white appearance under white light." [SANBI:mhl] subset: human_subset subset: mouse_subset xref: ZFA:0009261 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: BFO:0000002 is_a: CL:0000147 ! pigment cell is_a: CL:0000255 ! eukaryotic cell relationship: RO:0002202 CL:0005003 ! develops from leucoblast [Term] id: CL:0000573 name: retinal cone cell def: "One of the two photoreceptor cell types in the vertebrate retina. In cones the photopigment is in invaginations of the cell membrane of the outer segment. Cones are less sensitive to light than rods, but they provide vision with higher spatial and temporal acuity, and the combination of signals from cones with different pigments allows color vision." [MESH:D017949] subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "cone" RELATED [doi:10.1038/s41598-020-66092-9] xref: BTO:0001036 xref: CALOHA:TS-0866 xref: FMA:67748 xref: ZFA:0009262 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0010009 ! camera-type eye photoreceptor cell relationship: RO:0002202 CL:0002672 ! develops from retinal progenitor cell property_value: RO:0002175 NCBITaxon:9606 property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0000573" xsd:string {name="retinal cone cell on CELLxGENE CellGuide"} property_value: skos:prefLabel "retinal cone cell" xsd:string property_value: terms:description "Retinal cone cells, or simply cone cells, are one out of the two types of photoreceptor cells in the retina, the other being retinal rod cells. They function by converting light into signals that can lead to a visual perception. These cells are less sensitive to light compared to rod cells, but they play a crucial role in our vision system for their ability to perceive color and provide sharp visual acuity. They are responsible for our daylight and color vision, enabling an individual to perceive fine detail and rapid changes in light levels.\nCone cells are specialized and named based on the absorption spectra of the visual pigments they contain, giving rise to three types of cone cells: short-wavelength S-cones (blue cones), middle-wavelength M-cones (green cones), and long-wavelength L-cones (red cones). The distribution of these cones across the retina differs, with greater densities at the central fovea region, contributing to why our central vision is so sharp and color-detailed compared to peripheral vision.\nThe outer segments of retinal cone cells house the photopigments that absorb light and initiate the process of phototransduction, a biochemical event by which the light signal is transformed into an electrical signal. When a cone cell is stimulated by light, an electrochemical reaction triggers nerve impulses, which are then transmitted to the brain by the optic nerve. There, these impulses are processed into the images that we see. Each type of cone responds to different wavelengths of light, enabling us to perceive a spectrum of color. By working in conjunction with rod cells, which are adapted for low-light vision scenarios, the cone cells provide us with a comprehensive and adaptable vision system.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1016/j.preteyeres.2009.05.003", xref="DOI:10.1016/j.preteyeres.2010.11.001", xref="DOI:10.1113/JP282058", xref="DOI:10.1126/science.3576186", xref="DOI:10.1364/JOSAA.10.002491"} [Term] id: CL:0000574 name: erythrophore def: "A pigment cell derived from the neural crest. Contains pteridine and/or carotenoid pigments in structures called pterinosomes or erythrosomes. This gives an orange to red appearance." [SANBI:mhl] subset: human_subset subset: mouse_subset xref: ZFA:0009263 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: BFO:0000002 is_a: CL:0000147 ! pigment cell is_a: CL:0000255 ! eukaryotic cell relationship: RO:0002202 CL:0005004 ! develops from pigment erythroblast [Term] id: CL:0000575 name: corneal epithelial cell alt_id: CL:1000431 def: "An epithelial cell of the cornea." [GOC:tfm] subset: cellxgene_subset subset: eye_upper_slim subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "epithelial cell of cornea" EXACT [FMA:70551] xref: BTO:0004298 xref: CALOHA:TS-0173 xref: FMA:70551 xref: ZFA:0009264 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000076 ! squamous epithelial cell is_a: CL:0002159 ! general ecto-epithelial cell intersection_of: CL:0000076 ! squamous epithelial cell intersection_of: BFO:0000050 UBERON:0001772 ! part of corneal epithelium relationship: BFO:0000050 UBERON:0001772 ! part of corneal epithelium property_value: RO:0002175 NCBITaxon:9606 property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0000575" xsd:string {name="corneal epithelial cell on CELLxGENE CellGuide"} property_value: terms:description "Corneal epithelial cells are a specialized cell type that form the outermost layer of the cornea, the transparent dome-shaped tissue that covers the front of the eye. The corneal epithelium is 5-7 cells thick and is comprised of inner basal cells, middle wing cells and superficial squamous cells. \nThe corneal epithelium plays a crucial role in the maintenance of corneal transparency, protection against external insults, and the refractive power of the cornea. This cell type is responsible for the formation of tight junctions, desmosomes, and hemidesmosomes, which provide structural support to the corneal epithelium and prevent the infiltration of foreign particles and microorganisms. \nCorneal epithelial cells also have a unique and highly organized cytoskeleton that confers mechanical integrity and limits the penetration of foreign substances. Additionally, corneal epithelial cells secrete a variety of proteins and lipids that help to maintain the hydration and clarity of the cornea. These include mucins, which form a lubricating layer that facilitates blinking and limits dryness, and crystallins, which appear to protect against UV- and oxidative stress-induced apoptosis.\nDysfunction of corneal epithelial cells due to infections, inflammation, or injury can lead to corneal opacity, scarring, and impaired vision.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1016/S1350-9462(98)00001-9", xref="DOI:10.1016/j.semcdb.2007.09.015", xref="DOI:10.1097/ACI.0b013e32830e6b04", xref="DOI:10.1242/jcs.198119", xref="DOI:10.3390/cells10092302"} [Term] id: CL:0000576 name: monocyte def: "Myeloid mononuclear recirculating leukocyte that can act as a precursor of tissue macrophages, osteoclasts and some populations of tissue dendritic cells." [GO_REF:0000031, MESH:D009000] comment: Morphology: Mononuclear cell, diameter, 14 to 20 _M, N/C ratio 2:1-1:1. Nucleus may appear in variety of shapes: round, kidney, lobulated, or convoluted. Fine azurophilic granules present; markers: CD11b (shared with other myeloid cells), human: CD14, mouse: F4/80-mid,GR1-low; location: Blood, but can be recruited into tissues; role or process: immune & tissue remodelling; lineage: hematopoietic, myeloid. subset: blood_and_immune_upper_slim subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset xref: BTO:0000876 xref: CALOHA:TS-0638 xref: FMA:62864 xref: ZFA:0009265 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000113 ! mononuclear phagocyte is_a: CL:0000766 {is_inferred="true"} ! myeloid leukocyte is_a: CL:0011026 ! progenitor cell intersection_of: CL:0000766 ! myeloid leukocyte intersection_of: RO:0000053 PATO:0001407 ! has characteristic mononucleate intersection_of: RO:0002215 GO:0030225 ! capable of macrophage differentiation intersection_of: RO:0002215 GO:0030316 ! capable of osteoclast differentiation intersection_of: RO:0002215 GO:0043011 ! capable of myeloid dendritic cell differentiation relationship: RO:0002202 CL:0000559 ! develops from promonocyte relationship: RO:0002215 GO:0030225 ! capable of macrophage differentiation relationship: RO:0002215 GO:0030316 ! capable of osteoclast differentiation relationship: RO:0002215 GO:0043011 ! capable of myeloid dendritic cell differentiation property_value: RO:0002175 NCBITaxon:9606 property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0000576" xsd:string {name="monocyte on CELLxGENE CellGuide"} property_value: terms:description "Monocytes are a type of white blood cell that constitute part of the mononuclear phagocyte system. They feature prominently in the human body's first line of defense against foreign substances as a part of the innate immune system. Monocytes are the largest of all circulating leukocytes and are identified by their bean-shaped nucleus. They are produced in the bone marrow and circulate in the bloodstream; in some conditions, they may enter tissues and differentiate into macrophages or dendritic cells or a distinct monocyte-derived cell.\nMonocytes function effectively as phagocytes, devouring harmful pathogens in the body. They engulf and destroy microbes, foreign substances, cancer cells, and other materials detrimental to the body's well-being. This process, known as phagocytosis, is vital for the body's immune response. Monocytes are also equipped to identify harmful pathogens and alert other immune cells to their presence. This is achieved by producing proinflammatory cytokines that recruit other immune cells to the affected area, amplifying the immune response.\nBeyond their role in fighting infections, monocytes play an important role in the repair and healing of tissues. After an infection or inflammation subsides, monocytes can transition into different types of cells and assist in healing by clearing dead cells and debris and facilitating tissue regeneration. They are crucial in wound healing, control of microbial growth, and tissue development.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1016/j.immuni.2018.10.005", xref="DOI:10.1126/science.1178331", xref="DOI:10.1146/annurev.immunol.021908.132557"} [Term] id: CL:0000577 name: type EC enteroendocrine cell alt_id: CL:0002065 def: "A subtype of enteroendocrine cells found in the gastrointestinal mucosa, particularly in the glands of pyloric antrum; duodenum; and ileum. These cell type secretes serotonin and some neurotransmitters including enkephalins and substance P. Their secretory granules stain readily with silver (argentaffin stain)." [PMID:9505449] subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "argentaffin cell" EXACT [] synonym: "enterochromaffin cell" EXACT [] synonym: "Kulchitsky cell" EXACT [] xref: FMA:62934 xref: FMA:83132 xref: MESH:D004759 is_a: CL:0000164 ! enteroendocrine cell is_a: CL:0000166 ! chromaffin cell is_a: CL:0000458 ! serotonin secreting cell is_a: CL:0000506 ! enkephalin secreting cell relationship: BFO:0000050 UBERON:0004786 ! part of gastrointestinal system mucosa property_value: RO:0002175 NCBITaxon:9606 property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0000577" xsd:string {name="type EC enteroendocrine cell on CELLxGENE CellGuide"} property_value: terms:description "Type EC enteroendocrine cells, also known as enterochromaffin cells, are a vital hormone-secreting cell type found in the gastrointestinal tract. These cells are named after their location in the intestines (“entero”) and because they are stainable by chromium salts (“chromaffin”). \nThe primary function of type EC enteroendocrine cells is to act as chemosensors and lies in their capacity to produce and secrete serotonin, also known as 5-hydroxytryptamine (5-HT). Serotonin is a neurotransmitter that plays a significant role in modulating motility, secretion, vasodilation, perception of pain, and appetite in the gastrointestinal system. However, its function is not limited to the gastrointestinal tract; once secreted, serotonin is distributed via the bloodstream and contributes to regulating mood, appetite, and sleep in the brain. \nVia specific chemosensory receptors type EC enteroendocrine cells are able to respond to various environmental, metabolic, and homeostatic stimuli and transduce information from the gut to the nervous system: Food intake, particularly the ingestion of fats and carbohydrates, prompts these cells to produce and release serotonin; the mechanical stimulus of food in the lumen can also trigger release. The distribution, function, and responsiveness of type EC cells reveal them as a crucial link between the intestinal environment, the nervous system, and the regulation of numerous bodily functions.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1016/0166-4328(96)00075-7", xref="DOI:10.1016/j.cell.2017.05.034", xref="DOI:10.1038/s41574-019-0168-8", xref="DOI:10.1073/pnas.1804938115"} [Term] id: CL:0000578 name: experimentally modified cell in vitro def: "A cell in vitro that has undergone physical changes as a consequence of a deliberate and specific experimental procedure." [FB:ma, ReO:mhb] comment: This class has been re-labeled to imply reference only to in vitro experimentally modified cells, similarly, the definition has been slightly updated to reflect this. 'experimentally modified cell' refers only to cells in vitro, and not modified in vivo/in environment cells. There is currently no class representing unmodified in vitro cells (other than the parent 'cell in vitro'), or a class representing modified native cells. More granular subclassing of experimentally modified cell can be found in ReO. MHB 1.12.12 subset: human_subset subset: mouse_subset is_a: CL:0001034 ! cell in vitro [Term] id: CL:0000579 name: border follicle cell def: "A follicle cell that migrates from the anterior pole of the insect egg chamber to the anterior of the oocyte where they participate in the formation of the micropyle." [FBbt:00004905] xref: FBbt:00004905 {sssom:mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"} is_a: CL:0000477 ! follicle cell of egg chamber [Term] id: CL:0000580 name: neutrophilic myelocyte def: "A neutrophil precursor in the granulocytic series, being a cell intermediate in development between a promyelocyte and a metamyelocyte; in this stage, production of primary granules is complete and neutrophil-specific granules has started. No nucleolus is present. This cell type is CD13-positive, CD16-negative, integrin alpha-M-positive, CD15-positive, CD33-positive, CD24-positive, C/EBP-a-positive, C/EBPe-positive, PU.1-positive, lactotransferrin-positive, myeloperoxidase-positive and NGAL-positive." [GOC:add, GOC:dsd, GOC:tfm, http://www.cap.org, ISBN:0721601464, PMID:10618520, PMID:12560239, PMID:15514007] comment: These cells are also CD15-positive, CD35-negative, CD49d-positive, and fMLP receptor-negative. They are found in the Band 2 fraction. subset: human_subset subset: mouse_subset xref: BTO:0003455 xref: FMA:83540 xref: ZFA:0009266 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000776 {is_inferred="true"} ! immature neutrophil is_a: CL:0002087 ! nongranular leukocyte is_a: CL:0002193 ! myelocyte intersection_of: CL:0000776 ! immature neutrophil intersection_of: BFO:0000051 CL:0017502 ! has part acidophilic cytoplasm intersection_of: BFO:0000051 GO:0042582 ! has part azurophil granule intersection_of: BFO:0000051 PR:000001944 ! has part transcription factor PU.1 intersection_of: BFO:0000051 PR:000005307 ! has part CCAAT/enhancer-binding protein alpha intersection_of: BFO:0000051 PR:000005310 ! has part CCAAT/enhancer-binding protein epsilon intersection_of: BFO:0000051 PR:000009725 ! has part neutrophil gelatinase-associated lipocalin intersection_of: BFO:0000051 PR:000009978 ! has part lactotransferrin intersection_of: BFO:0000051 PR:000010543 ! has part myeloperoxidase intersection_of: CL:4030045 GO:0070820 ! lacks_part tertiary granule intersection_of: CL:4030046 PR:000001483 ! lacks_plasma_membrane_part low affinity immunoglobulin gamma Fc region receptor III intersection_of: RO:0002104 PR:000001012 ! has plasma membrane part integrin alpha-M intersection_of: RO:0002104 PR:000001456 ! has plasma membrane part alpha-(1,3)-fucosyltransferase 4 intersection_of: RO:0002104 PR:000001892 ! has plasma membrane part CD33 molecule intersection_of: RO:0002104 PR:000001932 ! has plasma membrane part signal transducer CD24 intersection_of: RO:0002104 PR:000002031 ! has plasma membrane part aminopeptidase N relationship: BFO:0000051 CL:0017502 ! has part acidophilic cytoplasm relationship: BFO:0000051 GO:0042582 ! has part azurophil granule relationship: BFO:0000051 PR:000001944 ! has part transcription factor PU.1 relationship: BFO:0000051 PR:000005307 ! has part CCAAT/enhancer-binding protein alpha relationship: BFO:0000051 PR:000005310 ! has part CCAAT/enhancer-binding protein epsilon relationship: BFO:0000051 PR:000009725 ! has part neutrophil gelatinase-associated lipocalin relationship: BFO:0000051 PR:000009978 ! has part lactotransferrin relationship: BFO:0000051 PR:000010543 ! has part myeloperoxidase relationship: CL:4030045 GO:0070820 ! lacks_part tertiary granule relationship: CL:4030046 PR:000001483 ! lacks_plasma_membrane_part low affinity immunoglobulin gamma Fc region receptor III relationship: RO:0002104 PR:000001456 ! has plasma membrane part alpha-(1,3)-fucosyltransferase 4 relationship: RO:0002104 PR:000001892 ! has plasma membrane part CD33 molecule relationship: RO:0002104 PR:000001932 ! has plasma membrane part signal transducer CD24 relationship: RO:0002104 PR:000002031 ! has plasma membrane part aminopeptidase N [Term] id: CL:0000581 name: peritoneal macrophage def: "A macrophage resident in the peritoneum under non-inflammatory conditions. Markers include F4/80-high, CD11b-high, CD68-positive, SIGNR1-positive, CD115-high, MHC-II-negative, and Dectin-1-positive." [MESH:D017737, PMID:15771589, PMID:19201820] comment: Markers: Mouse: F4/80-high, CD11b-high, CD68+, SIGNR1+, Dectin-1+. subset: human_subset subset: mouse_subset xref: BTO:0001034 xref: FMA:83025 xref: ZFA:0009267 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000864 {is_inferred="true"} ! tissue-resident macrophage intersection_of: CL:0000864 ! tissue-resident macrophage intersection_of: CL:4030046 GO:0042613 ! lacks_plasma_membrane_part MHC class II protein complex intersection_of: RO:0001025 UBERON:0001179 ! located in peritoneal cavity intersection_of: RO:0002104 PR:000001807 ! has plasma membrane part C-type lectin domain family 7 member A intersection_of: RO:0002104 PR:000002064 ! has plasma membrane part macrosialin intersection_of: RO:0002104 PR:000006172 ! has plasma membrane part CD209 molecule-like protein B intersection_of: RO:0002215 GO:0042742 ! capable of defense response to bacterium intersection_of: RO:0015015 PR:000001012 ! has high plasma membrane amount integrin alpha-M intersection_of: RO:0015015 PR:000001813 ! has high plasma membrane amount adhesion G protein-coupled receptor E1 intersection_of: RO:0015015 PR:000002062 ! has high plasma membrane amount macrophage colony-stimulating factor 1 receptor relationship: CL:4030046 GO:0042613 ! lacks_plasma_membrane_part MHC class II protein complex relationship: RO:0001025 UBERON:0001179 ! located in peritoneal cavity relationship: RO:0002104 PR:000001807 ! has plasma membrane part C-type lectin domain family 7 member A relationship: RO:0002104 PR:000002064 ! has plasma membrane part macrosialin relationship: RO:0002104 PR:000006172 ! has plasma membrane part CD209 molecule-like protein B relationship: RO:0002215 GO:0042742 ! capable of defense response to bacterium relationship: RO:0015015 PR:000001012 ! has high plasma membrane amount integrin alpha-M relationship: RO:0015015 PR:000001813 ! has high plasma membrane amount adhesion G protein-coupled receptor E1 relationship: RO:0015015 PR:000002062 ! has high plasma membrane amount macrophage colony-stimulating factor 1 receptor [Term] id: CL:0000582 name: neutrophilic metamyelocyte def: "A neutrophil precursor in the granulocytic series, being a cell intermediate in development between a myelocyte and the band form neutrophil. The protein synthesis seen in earlier stages decreases or stops; the nucleus becomes indented where the indentation is smaller than half the distance to the farthest nuclear margin; chromatin becomes coarse and clumped; specific granules predominate while primary granules are rare; and the cytoplasm becomes amphophilic like that of a mature granulocyte. This cell type is integrin alpha-M-positive, CD13-negative, CD15-positive, CD16-positive, CD33-positive, CD24-positive, fMLP receptor-negative and has expression of C/EBP-a, C/EBP-e, PU.1 transcription factor, lactotransferrin, myeloperoxidase and neutrophil gelatinase associated lipocalin." [GOC:add, GOC:dsd, GOC:tfm, http://www.cap.org, ISBN:0721601464, PMID:10618520, PMID:12560239, PMID:15514007] comment: These cells are also CD35-negative, CD49d-positive, and fMLP receptor-negative. They are found in the Band 2 fraction. subset: human_subset subset: mouse_subset synonym: "juvenile neutrophil" EXACT [] xref: FMA:84197 xref: ZFA:0009268 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000776 {is_inferred="true"} ! immature neutrophil is_a: CL:0002192 ! metamyelocyte intersection_of: CL:0000776 ! immature neutrophil intersection_of: BFO:0000051 CL:0017502 ! has part acidophilic cytoplasm intersection_of: BFO:0000051 CL:0017507 ! has part reniform nucleus intersection_of: BFO:0000051 GO:0000792 ! has part heterochromatin intersection_of: BFO:0000051 GO:0042582 ! has part azurophil granule intersection_of: BFO:0000051 GO:0070820 ! has part tertiary granule intersection_of: BFO:0000051 PR:000001944 ! has part transcription factor PU.1 intersection_of: BFO:0000051 PR:000005307 ! has part CCAAT/enhancer-binding protein alpha intersection_of: BFO:0000051 PR:000005310 ! has part CCAAT/enhancer-binding protein epsilon intersection_of: BFO:0000051 PR:000009725 ! has part neutrophil gelatinase-associated lipocalin intersection_of: BFO:0000051 PR:000009978 ! has part lactotransferrin intersection_of: BFO:0000051 PR:000010543 ! has part myeloperoxidase intersection_of: CL:4030046 PR:000001580 ! lacks_plasma_membrane_part fMet-Leu-Phe receptor intersection_of: RO:0002104 PR:000001012 ! has plasma membrane part integrin alpha-M intersection_of: RO:0002104 PR:000001456 ! has plasma membrane part alpha-(1,3)-fucosyltransferase 4 intersection_of: RO:0002104 PR:000001483 ! has plasma membrane part low affinity immunoglobulin gamma Fc region receptor III intersection_of: RO:0002104 PR:000001892 ! has plasma membrane part CD33 molecule intersection_of: RO:0002104 PR:000001932 ! has plasma membrane part signal transducer CD24 intersection_of: RO:0002104 PR:000002031 ! has plasma membrane part aminopeptidase N relationship: BFO:0000051 CL:0017502 ! has part acidophilic cytoplasm relationship: BFO:0000051 CL:0017507 ! has part reniform nucleus relationship: BFO:0000051 GO:0000792 ! has part heterochromatin relationship: BFO:0000051 GO:0042582 ! has part azurophil granule relationship: BFO:0000051 GO:0070820 ! has part tertiary granule relationship: BFO:0000051 PR:000001944 ! has part transcription factor PU.1 relationship: BFO:0000051 PR:000005307 ! has part CCAAT/enhancer-binding protein alpha relationship: BFO:0000051 PR:000005310 ! has part CCAAT/enhancer-binding protein epsilon relationship: BFO:0000051 PR:000009725 ! has part neutrophil gelatinase-associated lipocalin relationship: BFO:0000051 PR:000009978 ! has part lactotransferrin relationship: BFO:0000051 PR:000010543 ! has part myeloperoxidase relationship: CL:4030046 PR:000001580 ! lacks_plasma_membrane_part fMet-Leu-Phe receptor relationship: RO:0002104 PR:000001456 ! has plasma membrane part alpha-(1,3)-fucosyltransferase 4 relationship: RO:0002104 PR:000001483 ! has plasma membrane part low affinity immunoglobulin gamma Fc region receptor III relationship: RO:0002104 PR:000001892 ! has plasma membrane part CD33 molecule relationship: RO:0002104 PR:000001932 ! has plasma membrane part signal transducer CD24 relationship: RO:0002104 PR:000002031 ! has plasma membrane part aminopeptidase N relationship: RO:0002202 CL:0000580 ! develops from neutrophilic myelocyte [Term] id: CL:0000583 name: alveolar macrophage def: "A tissue-resident macrophage found in the alveoli of the lungs. Ingests small inhaled particles resulting in degradation and presentation of the antigen to immunocompetent cells. Markers include F4/80-positive, CD11b-/low, CD11c-positive, CD68-positive, sialoadhesin-positive, dectin-1-positive, MR-positive, CX3CR1-negative." [GO_REF:0000031, GOC:ana, GOC:dsd, GOC:tfm, MESH:D016676] comment: Markers: Mouse: F4/80mid, CD11b-/low, CD11c+, CD68+, sialoadhesin+, dectin-1+, MR+, CX3CR1-. The marker set MSR1, FABP4 can identify the Human cell type alveolar macrophage in the lung with a confidence of 0.80 (NS-Forest FBeta value). {xref="https://doi.org/10.5281/zenodo.11165918"} subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "dust cell" EXACT [] synonym: "MF.Lu" RELATED [] xref: BTO:0000802 xref: CALOHA:TS-0030 xref: FMA:83023 is_a: CL:0000864 {is_inferred="true"} ! tissue-resident macrophage is_a: CL:1001603 ! lung macrophage intersection_of: CL:0000864 ! tissue-resident macrophage intersection_of: CL:4030046 PR:000001206 ! lacks_plasma_membrane_part CX3C chemokine receptor 1 intersection_of: RO:0001025 UBERON:8850000 ! located in lumen of pulmonary alveolus intersection_of: RO:0002104 PR:000001013 ! has plasma membrane part integrin alpha-X intersection_of: RO:0002104 PR:000001807 ! has plasma membrane part C-type lectin domain family 7 member A intersection_of: RO:0002104 PR:000001813 ! has plasma membrane part adhesion G protein-coupled receptor E1 intersection_of: RO:0002104 PR:000001931 ! has plasma membrane part sialoadhesin intersection_of: RO:0002104 PR:000002064 ! has plasma membrane part macrosialin intersection_of: RO:0002104 PR:000002972 ! has plasma membrane part macrophage mannose receptor 1 intersection_of: RO:0002215 GO:0019882 ! capable of antigen processing and presentation intersection_of: RO:0015016 PR:000001012 ! has low plasma membrane amount integrin alpha-M relationship: CL:4030046 PR:000001206 ! lacks_plasma_membrane_part CX3C chemokine receptor 1 relationship: RO:0001025 UBERON:8850000 ! located in lumen of pulmonary alveolus relationship: RO:0002104 PR:000001013 ! has plasma membrane part integrin alpha-X relationship: RO:0002104 PR:000001807 ! has plasma membrane part C-type lectin domain family 7 member A relationship: RO:0002104 PR:000001813 ! has plasma membrane part adhesion G protein-coupled receptor E1 relationship: RO:0002104 PR:000001931 ! has plasma membrane part sialoadhesin relationship: RO:0002104 PR:000002064 ! has plasma membrane part macrosialin relationship: RO:0002104 PR:000002972 ! has plasma membrane part macrophage mannose receptor 1 relationship: RO:0015004 CLM:1000003 ! has characterizing marker set NS forest marker set of alveolar macrophage (Human lung). relationship: RO:0015016 PR:000001012 ! has low plasma membrane amount integrin alpha-M property_value: RO:0002175 NCBITaxon:9606 property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0000583" xsd:string {name="alveolar macrophage on CELLxGENE CellGuide"} property_value: terms:description "Alveolar macrophages are unique tissue-resident macrophages found in the lungs, specifically in the air sacs or alveoli where gas exchange occurs. They are characterized by specific surface markers including: F4/80-positive, CD11b-/low, CD11c-positive, CD68-positive, sialoadhesin-positive, dectin-1-positive, MR-positive, CX3CR1-negative. These specialized immune cells form a crucial part of the body's defense mechanism, playing important roles in pulmonary health and homeostasis. They are the first line of defense in the pulmonary immune response, acting as scavengers that patrol the alveoli and engulf foreign particles like bacteria, dust, and other debris that enter the lungs through inhalation.\nThe primary function of these alveolar macrophages is phagocytosis, whereby they consume and digest foreign substances, dead cells, and other particulates. In the lung, alveolar macrophages are also responsible for clearing surfactant. Additionally, alveolar macrophages also play an integral role in initiating the immune response, as they secrete several pro-inflammatory cytokines and chemokines that recruit other immune cells to the site of infection or inflammation.\nBeyond their role in host defense, alveolar macrophages contribute to tissue remodeling and wound repair in the lungs, aiding in maintaining lung integrity. They also regulate local inflammation and control the immune response to prevent excessive inflammation that may be harmful. However, an imbalance in the function of alveolar macrophages can contribute to various lung diseases. Abnormal alveolar macrophage activation has been implicated in chronic inflammatory diseases such as emphysema, asthma, and fibrosis.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1007/s00424-017-1965-3", xref="DOI:10.1016/j.cellimm.2018.01.005", xref="DOI:10.1038/nri3600", xref="DOI:10.14348/molcells.2021.0058"} [Term] id: CL:0000584 name: enterocyte def: "An epithelial cell that has its apical plasma membrane folded into microvilli to provide ample surface for the absorption of nutrients from the intestinal lumen." [SANBI:mhl] subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "differentiated enterocyte" NARROW [https://orcid.org/0000-0001-9610-7627, PMID:33290721] synonym: "mature enterocyte" NARROW [https://orcid.org/0000-0001-9610-7627, PMID:33290721] xref: BTO:0000398 xref: FMA:62122 xref: MESH:D020895 xref: ZFA:0009269 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000239 ! brush border epithelial cell is_a: CL:0000677 ! gut absorptive cell is_a: CL:0002563 ! intestinal epithelial cell property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0000585 name: obsolete null cell def: "OBSOLETE: A class of lymphocytes characterized by the lack of surface markers specific for either T or B cells." [] comment: This term is rather archaic; consider using 'natural killer cell ; CL:0000623', 'pro-B cell ; CL:0000826', 'pro-T cell ; CL:0000827', or other appropriate lymphocyte-related term depending on the context. is_obsolete: true [Term] id: CL:0000586 name: germ cell def: "The reproductive cell in multicellular organisms." [MESH:D005854] subset: cellxgene_subset subset: human_subset subset: mouse_subset xref: BTO:0000535 xref: NCIT:C12597 xref: VHOG:0001534 xref: WBbt:0006796 is_a: CL:0000039 {is_inferred="true"} ! germ line cell relationship: RO:0002216 GO:0009566 ! capable of part of fertilization property_value: skos:prefLabel "germ cell" xsd:string [Term] id: CL:0000587 name: cold sensing thermoreceptor cell def: "A thermoreceptor cell that detects reduced temperatures." [GOC:tfm] subset: human_subset subset: mouse_subset is_a: CL:0000205 ! thermoreceptor cell [Term] id: CL:0000588 name: odontoclast def: "A specialized osteoclast associated with the absorption and removal of cementum." [GOC:add] subset: human_subset subset: mouse_subset xref: BTO:0002516 xref: FMA:83027 xref: ZFA:0009270 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000092 {is_inferred="true"} ! osteoclast intersection_of: CL:0000092 ! osteoclast intersection_of: RO:0002215 GO:0042483 ! capable of negative regulation of odontogenesis relationship: RO:0002215 GO:0042483 ! capable of negative regulation of odontogenesis [Term] id: CL:0000589 name: cochlear inner hair cell def: "A bulbous cell that is medially placed in one row in the organ of Corti. In contrast to the outer hair cells, the inner hair cells are fewer in number, have fewer sensory hairs, and are less differentiated." [MESH:D006199] subset: human_subset subset: mouse_subset synonym: "inner hair cell" BROAD [] xref: BTO:0003667 xref: FMA:62365 is_a: CL:4023120 ! cochlea auditory hair cell [Term] id: CL:0000590 name: small luteal cell def: "A progesterone secreting cell in the corpus luteum that develops from theca cells." [GOC:tfm, MESH:D008184] subset: human_subset subset: mouse_subset synonym: "small lutein cell" EXACT [] synonym: "theca lutein cell" EXACT [] xref: BTO:0002850 xref: FMA:18690 is_a: BFO:0000002 is_a: CL:0000175 ! luteal cell relationship: RO:0002202 CL:0000503 ! develops from theca cell [Term] id: CL:0000591 name: warmth sensing thermoreceptor cell def: "A thermoreceptor cell that detects increased temperatures." [GOC:tfm, https://orcid.org/0000-0001-5208-3432] subset: human_subset subset: mouse_subset is_a: CL:0000205 ! thermoreceptor cell [Term] id: CL:0000592 name: large luteal cell def: "A large, progesterone secreting cell in the corpus luteum that develops from the granulosa cells." [GOC:tfm, MESH:D008184] subset: human_subset subset: mouse_subset synonym: "granulosa lutein cell" EXACT [] synonym: "granulosoluteocytus" RELATED [] xref: FMA:18689 is_a: BFO:0000002 is_a: CL:0000175 ! luteal cell is_a: CL:0000177 ! testosterone secreting cell relationship: RO:0002202 CL:0000501 ! develops from granulosa cell [Term] id: CL:0000593 name: androgen secreting cell def: "A steroid hormone secreting cell that secretes androgen." [GOC:tfm] subset: human_subset subset: mouse_subset xref: ZFA:0009271 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000174 ! steroid hormone secreting cell intersection_of: CL:0000151 ! secretory cell intersection_of: RO:0002215 GO:0035935 ! capable of androgen secretion relationship: RO:0002215 GO:0035935 ! capable of androgen secretion [Term] id: CL:0000594 name: skeletal muscle satellite cell def: "An elongated, spindle-shaped, cell that is located between the basal lamina and the plasmalemma of a muscle fiber. These cells are mostly quiescent, but upon activation they divide to produce cells that generate new muscle fibers." [GOC:tfm, MESH:D032496, PMID:21849021, PMID:23303905] comment: Skeletal muscle satellite cells are not traditionally referred to as myoblasts. They are a heterogeneous population whose division, following activiation, contributes to the formation of skeletal muscle fibers and to maintenance of the skeletal muscle statelite cell population. subset: cellxgene_subset subset: human_subset subset: mouse_subset xref: ZFA:0009272 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000188 ! cell of skeletal muscle is_a: CL:0000680 ! muscle precursor cell property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0000594" xsd:string {name="skeletal muscle satellite cell on CELLxGENE CellGuide"} property_value: terms:description "Skeletal muscle satellite cells (SMSCs) are a type of adult stem cell that nestles on the outer surface of the myofiber, positioned between the sarcolemma (plasma membrane of the muscle cell) and peripheral basement membrane. \nThe primary function of SMSCs lies in their capacity to facilitate the growth and repair of damaged skeletal muscle. Upon muscle injury or trauma, these normally quiescent cells activate, proliferate, and differentiate into myoblasts. These myoblasts subsequently mature and fuse to form myotubes, which ultimately help in the repair and rebuilding of muscle fibers. This response is an integral part of the skeletal muscle's ability to recover from injury and adapt to enhanced or changing physical demands, thereby maintaining and improving muscle function.\nFurthermore, SMSCs also contribute to hypertrophic muscle growth due to resistance exercise and endurance training, with the notable feature of their multi-nucleated nature resulting from the fusion of differentiated myoblasts. The additional nuclei support enhanced protein synthesis, thus allowing the muscle fibers to grow and strengthen in response to exercise. In aging and in diseases, the number or functionality of these cells can decrease, leading to impaired muscle regeneration and progressive muscle weakness.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1016/s1357-2725(03)00042-6", xref="DOI:10.1152/physrev.00061.2017", xref="DOI:10.1186/s13287-022-02706-5", xref="DOI:10.1369/0022155411426780", xref="DOI:10.22074/cellj.2016.4714"} [Term] id: CL:0000595 name: enucleate erythrocyte def: "An erythrocyte lacking a nucleus." [GOC:add, GOC:tfm] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "RBC" RELATED OMO:0003000 [] synonym: "red blood cell" BROAD [] is_a: CL:0000225 ! anucleate cell is_a: CL:0000232 {is_inferred="true"} ! erythrocyte intersection_of: CL:0000232 ! erythrocyte intersection_of: RO:0000053 PATO:0001405 ! has characteristic anucleate relationship: RO:0002202 CL:0002422 ! develops from enucleated reticulocyte [Term] id: CL:0000596 name: sexual spore def: "A spore formed following meiosis. Sometimes following meiosis, prospores may undergo one or more rounds of mitosis before they are fully mature." [FAO:0000017, GOC:tfm, SGD:clt] synonym: "meiotically-derived spore" EXACT [] xref: FAO:0000017 is_a: CL:0002369 ! fungal spore [Term] id: CL:0000597 name: microconidium def: "The smaller of two types of asexual spores formed by some fungi. An ovoid to pear-shaped asexual spore that contains very little cytoplasm and organelles, is uninucleate, and forms in vegetative hypae within a mycelium. Micronidia are extruded from the hyphal cell wall." [GOC:tfm, ISBN:0471940526, PMID:8357339, SGD:clt] xref: FAO:0000028 is_a: CL:0002381 ! uninucleate conidium [Term] id: CL:0000598 name: pyramidal neuron def: "Pyramidal neurons have a pyramid-shaped soma with a single axon, a large apical dendrite and multiple basal dendrites. The apex and an apical dendrite typically point toward the pial surface and other dendrites and an axon emerging from the base. The axons may have local collaterals but also project outside their region. Pyramidal neurons are found in the cerebral cortex, the hippocampus, and the amygdala." [GOC:tfm, MESH:D017966] subset: BDS_subset subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "projection neuron" EXACT [] synonym: "pyramidal cell" EXACT [] xref: BTO:0003102 xref: FMA:67310 xref: FMA:86775 xref: NIFSTD:sao862606388 xref: ZFA:0009273 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:2000029 ! central nervous system neuron intersection_of: CL:0000540 ! neuron intersection_of: RO:0000053 PATO:0070015 ! has characteristic pyramidal family morphology relationship: RO:0000053 PATO:0070015 ! has characteristic pyramidal family morphology property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0000598" xsd:string {name="pyramidal neuron on CELLxGENE CellGuide"} property_value: skos:prefLabel "pyramidal neuron" xsd:string property_value: terms:description "Pyramidal neurons, or pyramidal cells, are a distinctive type of neuron named for the triangular shape of their soma, or cell body. The primary characteristic of these neurons is a large apical dendrite that ascends toward the cortical surface, numerous basal dendrites, and a single axon. These neurons are found within parts of the brain including the cerebral cortex, the hippocampus, and the amygdala, playing a critical role in cortex communication, cognitive function, and the relay of information within the brain's neural network.\nFunctional roles of pyramidal neurons depend largely on their localization. However, all types of these neurons serve as principal cells within the grey matter of the brain, transmitting signals over long distances. Primarily, pyramidal cells function as excitatory neurons; they disseminate action potential outputs to other neurons which they are connected to across the synapse. In the cerebral cortex, pyramidal neurons are paramount for sensory perception and motor command, while those located in the hippocampus involve in memory and learning processes.\nFiring properties of these neurons such as regular spiking and bursting are notable features thought to play a role in synaptic plasticity and signaling. Together, their unique anatomical structure and intricate connectivity underpin their critical function in brain neural networks, significantly contributing to human cognitive abilities. In addition, abnormalities in pyramidal neurons have been linked to a range of neurodegenerative and psychiatric disorders, emphasizing their importance in maintaining healthy neural function.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1002/jnr.23978", xref="DOI:10.1016/S0896-6273(01)00447-0", xref="DOI:10.1038/nrn2286", xref="DOI:10.1038/s41583-019-0125-5", xref="DOI:10.1093/cercor/bhg093"} [Term] id: CL:0000599 name: conidium def: "An asexual, nonmotile spore formed by higher fungi; conidia are usually made from the side or tip of specialized sporogenous cells and do not form by progressive cleavage of the cytoplasm." [ISBN:08199377X, PMID:2524423, PMID:9529886, SGD:clt] xref: BTO:0000283 xref: FAO:0000024 is_a: CL:0000605 ! fungal asexual spore [Term] id: CL:0000600 name: heterokaryon def: "A fungal cell with two or more genetically distinct nuclei." [ISBN:08199377X] is_a: CL:0000228 ! multinucleate cell is_a: CL:0000521 ! fungal cell [Term] id: CL:0000601 name: cochlear outer hair cell def: "A mechanoreceptor in the organ of Corti. In mammals the outer hair cells are arranged in three rows which are further from the modiolus than the single row of inner hair cells. The motile properties of the outer hair cells may contribute actively to tuning the sensitivity and frequency selectivity of the cochlea." [MESH:D018072] subset: human_subset subset: mouse_subset xref: BTO:0003666 xref: FMA:62366 is_a: CL:4023120 ! cochlea auditory hair cell [Term] id: CL:0000602 name: pressoreceptor cell def: "A receptor in the vascular system, particularly the aorta and carotid sinus, which is sensitive to stretch of the vessel walls." [MESH:D011311] subset: human_subset subset: mouse_subset xref: ZFA:0009274 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:1000082 ! stretch receptor cell [Term] id: CL:0000603 name: dikaryon def: "A fungal cell with two genetically distinct haploid nuclei." [ISBN:08199377X] is_a: CL:0000227 ! binucleate cell is_a: CL:0000600 ! heterokaryon [Term] id: CL:0000604 name: retinal rod cell def: "One of the two photoreceptor cell types of the vertebrate retina. In rods the photopigment is in stacks of membranous disks separate from the outer cell membrane. Rods are more sensitive to light than cones, but rod mediated vision has less spatial and temporal resolution than cone vision." [MESH:D017948] subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "rod" RELATED [doi:10.1038/s41598-020-66092-9] xref: BTO:0001024 xref: CALOHA:TS-0870 xref: FMA:67747 xref: ZFA:0009275 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0010009 ! camera-type eye photoreceptor cell relationship: RO:0002202 CL:0002672 ! develops from retinal progenitor cell property_value: RO:0002175 NCBITaxon:9606 property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0000604" xsd:string {name="retinal rod cell on CELLxGENE CellGuide"} property_value: skos:prefLabel "retinal rod cell" xsd:string property_value: terms:description "Retinal rod cells, often referred to simply as \"rod cells”, are a specialized type of photoreceptor cells found in the retina. Their primary function is to detect and convert light into electrochemical signals, which are then transmitted to the brain via nerve impulses. Compared to other types of photoreceptor cells, namely retinal cone cells, rod cells are more sensitive to light, and thus play a crucial role in night and peripheral vision.\nRod cells are named for their long, cylindrical shape, which is distinct from the cone-like shape of retinal cone cells. The structure of a rod cell is complex, with different sections responsible for various aspects of its function. The outer segment contains densely packed, light-sensitive membrane discs filled with a pigment called rhodopsin. When light hits rhodopsin, it prompts a chemical reaction that leads to the generation of electrochemical signals. These signals are processed in the cell's inner segment, which contains the cell's primary organelles, including the nucleus and mitochondria, and transmitted through the cell's synaptic terminal to the secondary neurons in the retina.\nRod cells are distributed across the majority of the retina, with the highest density found in the peripheral edges. This distribution, coupled with their high sensitivity to light, explains why rod cells contribute significantly to peripheral and low-light vision. However, they do not pick up color and have low spatial acuity, which means that while rod cells can detect the presence of light and movement, the finer details and colors of an image are processed mainly by cone cells. Together, rod cells and cone cells work in concert to enable a wide range of visual capabilities, making vision a complex and intricate biological process.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1002/cne.902920402", xref="DOI:10.1016/0968-0004(83)90235-9", xref="DOI:10.1016/j.preteyeres.2016.06.002", xref="DOI:10.1038/eye.2015.236", xref="DOI:10.1113/JP282058"} [Term] id: CL:0000605 name: fungal asexual spore def: "A spore formed following mitosis or mitoses." [GOC:tfm, PMID:2524423, PMID:9529886, SGD:clt] xref: FAO:0000023 is_a: CL:0002369 ! fungal spore [Term] id: CL:0000606 name: macroconidium def: "The larger of two types of asexual spores formed by some fungi; usually round or oblong." [GOC:tfm, ISBN:0471940526, SGD:clt] xref: FAO:0000038 is_a: CL:0000599 ! conidium [Term] id: CL:0000607 name: ascospore def: "A thick walled spore that stores and protects one or more nuclei following sexual reproduction in an Ascomycete." [GOC:tfm, ISBN:08199377X, SGD:clt] xref: BTO:0000097 xref: FAO:0000020 is_a: CL:0000596 ! sexual spore [Term] id: CL:0000608 name: zygospore def: "A thick walled, sexual, resting spore formed by Zygomycetes; sometimes refers to the spore and the multi-layered cell wall that encloses the spore, the zygosporangium." [ISBN:0471940526, ISBN:08199377X, SGD:clt] xref: FAO:0000040 is_a: CL:0000596 ! sexual spore [Term] id: CL:0000609 name: vestibular hair cell def: "A mechanoreceptor located in the acoustic maculae and the semicircular canals that mediates the sense of balance, movement, and head position. The vestibular hair cells are connected to accessory structures in such a way that movements of the head displace their stereocilia. This influences the membrane potential of the cells which relay information about movements via the vestibular part of the vestibulocochlear nerve to the brain stem." [GOC:tfm, MESH:D018069] subset: human_subset subset: mouse_subset synonym: "vestibular receptor cell" EXACT [] xref: FMA:62351 is_a: CL:0002374 ! ear hair cell [Term] id: CL:0000610 name: obsolete plant cell comment: This term was obsoleted as it is redundant with PO:0009002 in the cell ontology (PO) is_obsolete: true consider: PO:0009002 [Term] id: CL:0000611 name: eosinophil progenitor cell def: "Any granulocytopoietic cell that has part some transcription factor PU.1 and has part some CCAAT/enhancer-binding protein alpha and has part some erythroid transcription factor and lacks plasma membrane part some CD19 molecule and lacks plasma membrane part some CD4 molecule and lacks plasma membrane part some integrin alpha-M and lacks plasma membrane part some CD3 epsilon and lacks plasma membrane part some neural cell adhesion molecule 1 and lacks plasma membrane part some CD2 molecule and lacks plasma membrane part some T-cell surface glycoprotein CD8 alpha chain and lacks plasma membrane part some membrane-spanning 4-domains subfamily A member 1 and lacks plasma membrane part some T-cell surface glycoprotein CD5 and lacks plasma membrane part some CD14 molecule and lacks plasma membrane part some lymphocyte antigen 6G and lacks plasma membrane part some lymphocyte antigen 76 (mouse) and has plasma membrane part some CD34 molecule and has plasma membrane part some ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 and has plasma membrane part some interleukin-3 receptor class 2 alpha chain and has plasma membrane part some interleukin-5 receptor subunit alpha and has plasma membrane part some mast/stem cell growth factor receptor and is capable of some eosinophil differentiation." [FBC:Autogenerated] comment: These cells are CD34-positive, CD45RA-negative, CD71-negative, and lineage-negative (CD2, CD3 epsilon, CD4, CD5, CD8a, CD14, CD19, CD20, integrin alpha-M, NCAM-1, SCA-1, Ly6G, Ly76). subset: human_subset subset: mouse_subset synonym: "CFU-Eo" RELATED OMO:0003000 [] synonym: "colony forming unit eosinophil" RELATED [] synonym: "EoP" RELATED OMO:0003000 [PMCID:PMC2212039, PMCID:PMC2626675] synonym: "eosinophil stem cell" RELATED [] is_a: CL:0000763 ! myeloid cell is_a: CL:0002191 {is_inferred="true"} ! granulocytopoietic cell intersection_of: CL:0002191 ! granulocytopoietic cell intersection_of: BFO:0000051 PR:000001944 ! has part transcription factor PU.1 intersection_of: BFO:0000051 PR:000005307 ! has part CCAAT/enhancer-binding protein alpha intersection_of: BFO:0000051 PR:000007857 ! has part erythroid transcription factor intersection_of: CL:4030046 PR:000001002 ! lacks_plasma_membrane_part CD19 molecule intersection_of: CL:4030046 PR:000001004 ! lacks_plasma_membrane_part CD4 molecule intersection_of: CL:4030046 PR:000001012 ! lacks_plasma_membrane_part integrin alpha-M intersection_of: CL:4030046 PR:000001020 ! lacks_plasma_membrane_part CD3 epsilon intersection_of: CL:4030046 PR:000001024 ! lacks_plasma_membrane_part neural cell adhesion molecule 1 intersection_of: CL:4030046 PR:000001083 ! lacks_plasma_membrane_part CD2 molecule intersection_of: CL:4030046 PR:000001084 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD8 alpha chain intersection_of: CL:4030046 PR:000001289 ! lacks_plasma_membrane_part membrane-spanning 4-domains subfamily A member 1 intersection_of: CL:4030046 PR:000001839 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD5 intersection_of: CL:4030046 PR:000001889 ! lacks_plasma_membrane_part CD14 molecule intersection_of: CL:4030046 PR:000002978 ! lacks_plasma_membrane_part lymphocyte antigen 6G intersection_of: CL:4030046 PR:000002981 ! lacks_plasma_membrane_part lymphocyte antigen 76 (mouse) intersection_of: RO:0002104 PR:000001003 ! has plasma membrane part CD34 molecule intersection_of: RO:0002104 PR:000001408 ! has plasma membrane part ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 intersection_of: RO:0002104 PR:000001865 ! has plasma membrane part interleukin-3 receptor class 2 alpha chain intersection_of: RO:0002104 PR:000001867 ! has plasma membrane part interleukin-5 receptor subunit alpha intersection_of: RO:0002104 PR:000002065 ! has plasma membrane part mast/stem cell growth factor receptor intersection_of: RO:0002215 GO:0030222 ! capable of eosinophil differentiation relationship: BFO:0000051 PR:000001944 ! has part transcription factor PU.1 relationship: BFO:0000051 PR:000005307 ! has part CCAAT/enhancer-binding protein alpha relationship: BFO:0000051 PR:000007857 ! has part erythroid transcription factor relationship: CL:4030046 PR:000001002 ! lacks_plasma_membrane_part CD19 molecule relationship: CL:4030046 PR:000001004 ! lacks_plasma_membrane_part CD4 molecule relationship: CL:4030046 PR:000001012 ! lacks_plasma_membrane_part integrin alpha-M relationship: CL:4030046 PR:000001020 ! lacks_plasma_membrane_part CD3 epsilon relationship: CL:4030046 PR:000001024 ! lacks_plasma_membrane_part neural cell adhesion molecule 1 relationship: CL:4030046 PR:000001083 ! lacks_plasma_membrane_part CD2 molecule relationship: CL:4030046 PR:000001084 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD8 alpha chain relationship: CL:4030046 PR:000001289 ! lacks_plasma_membrane_part membrane-spanning 4-domains subfamily A member 1 relationship: CL:4030046 PR:000001839 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD5 relationship: CL:4030046 PR:000001889 ! lacks_plasma_membrane_part CD14 molecule relationship: CL:4030046 PR:000002978 ! lacks_plasma_membrane_part lymphocyte antigen 6G relationship: CL:4030046 PR:000002981 ! lacks_plasma_membrane_part lymphocyte antigen 76 (mouse) relationship: RO:0002104 PR:000001003 ! has plasma membrane part CD34 molecule relationship: RO:0002104 PR:000001408 ! has plasma membrane part ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 relationship: RO:0002104 PR:000001865 ! has plasma membrane part interleukin-3 receptor class 2 alpha chain relationship: RO:0002104 PR:000001867 ! has plasma membrane part interleukin-5 receptor subunit alpha relationship: RO:0002104 PR:000002065 ! has plasma membrane part mast/stem cell growth factor receptor relationship: RO:0002202 CL:0000557 ! develops from granulocyte monocyte progenitor cell relationship: RO:0002215 GO:0030222 ! capable of eosinophil differentiation [Term] id: CL:0000612 name: eosinophilic myelocyte def: "A eosinophil precursor in the granulocytic series, being a cell intermediate in development between a promyelocyte and a metamyelocyte;in this stage, production of primary granules is complete and eosinophil-specific granules has started. No nucleolus is present. These cells are integrin alpha-M-positive, CD13-positive, CD15-positive, CD16-negative, CD24-positive, and CD33-positive." [GOC:add, GOC:dsd, http://www.cap.org, ISBN:0721601464, PMID:19622087] subset: human_subset subset: mouse_subset xref: BTO:0003454 xref: FMA:83542 is_a: CL:0000772 {is_inferred="true"} ! immature eosinophil is_a: CL:0002087 ! nongranular leukocyte is_a: CL:0002193 ! myelocyte intersection_of: CL:0000772 ! immature eosinophil intersection_of: BFO:0000051 GO:0042582 ! has part azurophil granule intersection_of: CL:4030045 GO:0070820 ! lacks_part tertiary granule intersection_of: CL:4030046 PR:000001483 ! lacks_plasma_membrane_part low affinity immunoglobulin gamma Fc region receptor III intersection_of: RO:0002104 PR:000001012 ! has plasma membrane part integrin alpha-M intersection_of: RO:0002104 PR:000001456 ! has plasma membrane part alpha-(1,3)-fucosyltransferase 4 intersection_of: RO:0002104 PR:000001892 ! has plasma membrane part CD33 molecule intersection_of: RO:0002104 PR:000001932 ! has plasma membrane part signal transducer CD24 intersection_of: RO:0002104 PR:000002031 ! has plasma membrane part aminopeptidase N relationship: BFO:0000051 GO:0042582 ! has part azurophil granule relationship: CL:4030045 GO:0070820 ! lacks_part tertiary granule relationship: CL:4030046 PR:000001483 ! lacks_plasma_membrane_part low affinity immunoglobulin gamma Fc region receptor III relationship: RO:0002104 PR:000001456 ! has plasma membrane part alpha-(1,3)-fucosyltransferase 4 relationship: RO:0002104 PR:000001892 ! has plasma membrane part CD33 molecule relationship: RO:0002104 PR:000001932 ! has plasma membrane part signal transducer CD24 relationship: RO:0002104 PR:000002031 ! has plasma membrane part aminopeptidase N [Term] id: CL:0000613 name: basophil progenitor cell def: "A progenitor cell committed to the basophil lineage. This cell lacks hematopoietic lineage markers (lin-negative) and is CD34-positive, T1/ST2-low, CD117-negative, and FceRIa-high. This cell also expresses Gata-1, Gata-2 and C/EBPa." [GOC:add, GOC:dsd, http://www.copewithcytokines.de, PMCID:PMC1312421] comment: BaP are also CD13-low and integrin beta-7-low. They are lin-negative (CD2, CD3e, CD4, CD5, CD8, CD11b, CD14, CD19, CD20, ly6g, ly76, and NCAM-1). They also lack expression of mast cell protease 1 (MCP-1) and microphthalmia-associated transcription factor (mitf). subset: human_subset subset: mouse_subset synonym: "BaP" EXACT [] synonym: "basophilic stem cell" RELATED [] synonym: "CFU-Bas" RELATED [] synonym: "colony forming unit basophil" RELATED [] is_a: CL:0000763 ! myeloid cell is_a: CL:0002191 {is_inferred="true"} ! granulocytopoietic cell intersection_of: CL:0002191 ! granulocytopoietic cell intersection_of: BFO:0000051 PR:000005307 ! has part CCAAT/enhancer-binding protein alpha intersection_of: BFO:0000051 PR:000007857 ! has part erythroid transcription factor intersection_of: BFO:0000051 PR:000007858 ! has part endothelial transcription factor GATA-2 intersection_of: CL:4030046 PR:000001002 ! lacks_plasma_membrane_part CD19 molecule intersection_of: CL:4030046 PR:000001004 ! lacks_plasma_membrane_part CD4 molecule intersection_of: CL:4030046 PR:000001012 ! lacks_plasma_membrane_part integrin alpha-M intersection_of: CL:4030046 PR:000001020 ! lacks_plasma_membrane_part CD3 epsilon intersection_of: CL:4030046 PR:000001024 ! lacks_plasma_membrane_part neural cell adhesion molecule 1 intersection_of: CL:4030046 PR:000001083 ! lacks_plasma_membrane_part CD2 molecule intersection_of: CL:4030046 PR:000001084 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD8 alpha chain intersection_of: CL:4030046 PR:000001289 ! lacks_plasma_membrane_part membrane-spanning 4-domains subfamily A member 1 intersection_of: CL:4030046 PR:000001839 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD5 intersection_of: CL:4030046 PR:000001889 ! lacks_plasma_membrane_part CD14 molecule intersection_of: CL:4030046 PR:000002065 ! lacks_plasma_membrane_part mast/stem cell growth factor receptor intersection_of: CL:4030046 PR:000002978 ! lacks_plasma_membrane_part lymphocyte antigen 6G intersection_of: CL:4030046 PR:000002981 ! lacks_plasma_membrane_part lymphocyte antigen 76 (mouse) intersection_of: RO:0002215 GO:0030221 ! capable of basophil differentiation intersection_of: RO:0015015 PR:000007431 ! has high plasma membrane amount high affinity immunoglobulin epsilon receptor subunit alpha intersection_of: RO:0015016 PR:000016401 ! has low plasma membrane amount transmembrane emp24 domain-containing protein 1 relationship: BFO:0000051 PR:000005307 ! has part CCAAT/enhancer-binding protein alpha relationship: BFO:0000051 PR:000007857 ! has part erythroid transcription factor relationship: BFO:0000051 PR:000007858 ! has part endothelial transcription factor GATA-2 relationship: CL:4030046 PR:000001002 ! lacks_plasma_membrane_part CD19 molecule relationship: CL:4030046 PR:000001004 ! lacks_plasma_membrane_part CD4 molecule relationship: CL:4030046 PR:000001012 ! lacks_plasma_membrane_part integrin alpha-M relationship: CL:4030046 PR:000001020 ! lacks_plasma_membrane_part CD3 epsilon relationship: CL:4030046 PR:000001024 ! lacks_plasma_membrane_part neural cell adhesion molecule 1 relationship: CL:4030046 PR:000001083 ! lacks_plasma_membrane_part CD2 molecule relationship: CL:4030046 PR:000001084 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD8 alpha chain relationship: CL:4030046 PR:000001289 ! lacks_plasma_membrane_part membrane-spanning 4-domains subfamily A member 1 relationship: CL:4030046 PR:000001839 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD5 relationship: CL:4030046 PR:000001889 ! lacks_plasma_membrane_part CD14 molecule relationship: CL:4030046 PR:000002065 ! lacks_plasma_membrane_part mast/stem cell growth factor receptor relationship: CL:4030046 PR:000002978 ! lacks_plasma_membrane_part lymphocyte antigen 6G relationship: CL:4030046 PR:000002981 ! lacks_plasma_membrane_part lymphocyte antigen 76 (mouse) relationship: RO:0002202 CL:0002028 ! develops from basophil mast progenitor cell relationship: RO:0002215 GO:0030221 ! capable of basophil differentiation relationship: RO:0015015 PR:000007431 ! has high plasma membrane amount high affinity immunoglobulin epsilon receptor subunit alpha relationship: RO:0015016 PR:000016401 ! has low plasma membrane amount transmembrane emp24 domain-containing protein 1 [Term] id: CL:0000614 name: basophilic myelocyte def: "A basophil precursor in the granulocytic series, being a cell intermediate in development between a promyelocyte and a metamyelocyte; in this stage, production of primary granules is complete and basophil-specific granules has started. No nucleolus is present. Markers are being integrin alpha-M-positive, fucosyltransferase FUT4-positive, CD33-positive, CD24-positive, aminopeptidase N-positive." [GOC:add, GOC:tfm, http://www.cap.org, ISBN:0721601464, PMID:18466030] subset: human_subset subset: mouse_subset xref: BTO:0003456 xref: FMA:83543 is_a: CL:0000768 {is_inferred="true"} ! immature basophil is_a: CL:0002087 ! nongranular leukocyte intersection_of: CL:0000768 ! immature basophil intersection_of: BFO:0000051 GO:0042582 ! has part azurophil granule intersection_of: CL:4030045 GO:0005730 ! lacks_part nucleolus intersection_of: CL:4030045 GO:0070820 ! lacks_part tertiary granule intersection_of: CL:4030046 PR:000001483 ! lacks_plasma_membrane_part low affinity immunoglobulin gamma Fc region receptor III intersection_of: RO:0002104 PR:000001012 ! has plasma membrane part integrin alpha-M intersection_of: RO:0002104 PR:000001456 ! has plasma membrane part alpha-(1,3)-fucosyltransferase 4 intersection_of: RO:0002104 PR:000001892 ! has plasma membrane part CD33 molecule intersection_of: RO:0002104 PR:000001932 ! has plasma membrane part signal transducer CD24 intersection_of: RO:0002104 PR:000002031 ! has plasma membrane part aminopeptidase N relationship: BFO:0000051 GO:0042582 ! has part azurophil granule relationship: CL:4030045 GO:0005730 ! lacks_part nucleolus relationship: CL:4030045 GO:0070820 ! lacks_part tertiary granule relationship: CL:4030046 PR:000001483 ! lacks_plasma_membrane_part low affinity immunoglobulin gamma Fc region receptor III relationship: RO:0002104 PR:000001456 ! has plasma membrane part alpha-(1,3)-fucosyltransferase 4 relationship: RO:0002104 PR:000001892 ! has plasma membrane part CD33 molecule relationship: RO:0002104 PR:000001932 ! has plasma membrane part signal transducer CD24 relationship: RO:0002104 PR:000002031 ! has plasma membrane part aminopeptidase N [Term] id: CL:0000615 name: basidiospore def: "A thick walled spore containing one or more haploid nuclei produced by sexual reproduction in an Basidiomycete; formed externally on extrusions of the basidium." [GOC:clt, ISBN:0471940526, ISBN:08199377X] xref: BTO:0002166 xref: FAO:0000021 is_a: CL:0000596 ! sexual spore [Term] id: CL:0000616 name: obsolete sporangiospore def: "OBSOLETE: A walled spore produced in a sporangium." [ISBN:08199377X] is_obsolete: true [Term] id: CL:0000617 name: GABAergic neuron def: "A neuron that uses GABA as a vesicular neurotransmitter" [GOC:tfm] subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "GABA-ergic neuron" EXACT [] xref: FBbt:00007228 {sssom:mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"} xref: FMA:84788 xref: MESH:D059330 xref: WBbt:0005190 xref: ZFA:0009276 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000151 ! secretory cell is_a: CL:0000540 ! neuron intersection_of: CL:0000540 ! neuron intersection_of: RO:0002215 GO:0061534 ! capable of gamma-aminobutyric acid secretion, neurotransmission relationship: RO:0002215 GO:0061534 ! capable of gamma-aminobutyric acid secretion, neurotransmission property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "GABAergic neuron" xsd:string [Term] id: CL:0000618 name: sheath cell subset: human_subset subset: mouse_subset is_a: CL:0000075 ! columnar/cuboidal epithelial cell [Term] id: CL:0000619 name: supporting cell (sensu Nematoda) subset: human_subset subset: mouse_subset synonym: "support cell (sensu Nematoda)" EXACT [] is_a: CL:0000378 ! supporting cell (sensu Nematoda and Protostomia) [Term] id: CL:0000620 name: obsolete zoospore def: "OBSOLETE: A sporangiospore that is motile, having flagella." [ISBN:08199377X] xref: FAO:0000039 is_obsolete: true [Term] id: CL:0000621 name: fusion competent myoblast def: "A myoblast that is committed to a myotube-specific program of differentiation but not yet fused. It undergoes very limited additional proliferation. After fusion, it will take on a muscle identity specified by a `muscle founder cell` (CL:0008006)." [PMID:22274696] subset: human_subset subset: mouse_subset is_a: CL:0008018 ! somatic muscle myoblast [Term] id: CL:0000622 name: acinar cell def: "A secretory cell that is grouped together with other cells of the same type to form grape shaped clusters known as acini (singular acinus)." [GOC:tfm, http://www.copewithcytokines.de] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "acinic cell" EXACT [] synonym: "acinous cell" EXACT [] xref: FMA:83625 xref: MESH:D061354 xref: ZFA:0009277 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000150 ! glandular secretory epithelial cell is_a: CL:0000154 ! protein secreting cell intersection_of: CL:0000150 ! glandular secretory epithelial cell intersection_of: CL:0000154 ! protein secreting cell intersection_of: BFO:0000050 UBERON:0009842 ! part of glandular acinus relationship: BFO:0000050 UBERON:0009842 ! part of glandular acinus property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0000622" xsd:string {name="acinar cell on CELLxGENE CellGuide"} property_value: terms:description "Acinar cells are specialized exocrine gland cells that secrete specific enzymes and fluids to aid in digestion. Found primarily in the pancreas and salivary glands, the term acinar is derived from the Latin word 'acinus' which means 'grape'; this is because acinar cells are arranged in a grape-like cluster around small ducts, formulating an acinus structure. \nIn the salivary glands, acinar cells secrete digestive enzymes as well as other substances such as mucus and water. These secretions service the initial stages of the digestive process, preparing the consumed food for onward digestion in the stomach and intestines by lubricating and partially breaking it down. \nIn the pancreas, acinar cells are responsible for synthesizing and secreting a significant amount of digestive enzymes, such as trypsin, chymotrypsin, and amylase. These enzymes are stored in zymogen granules inside the acinar cells until they are dispatched into the small intestine. Once within the small intestine, they break down proteins, carbohydrates, and fats into substances that can be absorbed. This is vital to the effective and efficient digestion and absorption of nutrients from the food we consume. \nAcinar cells have high protein synthesis rates and are susceptible to accumulation of misfolded proteins; the subsequential induction of ER stress is thought to be involved in the development of pancreatitis, a serious inflammatory disease of the exocrine pancreas.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1007/BF00710764", xref="DOI:10.1038/nrgastro.2013.36", xref="DOI:10.1097/MOG.0b013e32832ebfac", xref="DOI:10.1111/prd.12116", xref="DOI:10.1152/physrev.00011.2011"} [Term] id: CL:0000623 name: natural killer cell def: "A lymphocyte that can spontaneously kill a variety of target cells without prior antigenic activation via germline encoded activation receptors and also regulate immune responses via cytokine release and direct contact with other cells." [GOC:add, ISBN:0781735149, PMID:15771571] subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "large granular lymphocyte" BROAD [] synonym: "NK cell" EXACT [] synonym: "null cell" BROAD [] xref: BTO:0000914 xref: BTO:0004716 xref: CALOHA:TS-0664 xref: FMA:63147 xref: FMA:83601 xref: MESH:D007694 xref: VHOG:0001697 xref: ZFA:0009278 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0001067 ! group 1 innate lymphoid cell intersection_of: CL:0001067 ! group 1 innate lymphoid cell intersection_of: CL:4030046 PR:000001002 ! lacks_plasma_membrane_part CD19 molecule intersection_of: CL:4030046 PR:000001020 ! lacks_plasma_membrane_part CD3 epsilon intersection_of: CL:4030046 PR:000001289 ! lacks_plasma_membrane_part membrane-spanning 4-domains subfamily A member 1 intersection_of: CL:4030046 PR:000001889 ! lacks_plasma_membrane_part CD14 molecule intersection_of: RO:0002215 GO:0002228 ! capable of natural killer cell mediated immunity intersection_of: RO:0002215 GO:0050776 ! capable of regulation of immune response relationship: CL:4030046 PR:000001289 ! lacks_plasma_membrane_part membrane-spanning 4-domains subfamily A member 1 relationship: CL:4030046 PR:000001889 ! lacks_plasma_membrane_part CD14 molecule relationship: RO:0002202 CL:0000825 ! develops from pro-NK cell relationship: RO:0002215 GO:0002228 ! capable of natural killer cell mediated immunity relationship: RO:0002215 GO:0050776 ! capable of regulation of immune response property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0000624 name: CD4-positive, alpha-beta T cell def: "A mature alpha-beta T cell that expresses an alpha-beta T cell receptor and the CD4 coreceptor." [GOC:add, ISBN:0781735149] subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "CD4-positive, alpha-beta T lymphocyte" EXACT [] synonym: "CD4-positive, alpha-beta T-cell" EXACT [] synonym: "CD4-positive, alpha-beta T-lymphocyte" EXACT [] is_a: CL:0000791 {is_inferred="true"} ! mature alpha-beta T cell intersection_of: CL:0000791 ! mature alpha-beta T cell intersection_of: CL:4030046 PR:000025402 ! lacks_plasma_membrane_part T cell receptor co-receptor CD8 intersection_of: RO:0002104 PR:000001004 ! has plasma membrane part CD4 molecule disjoint_from: CL:0000625 ! CD8-positive, alpha-beta T cell relationship: CL:4030046 PR:000025402 ! lacks_plasma_membrane_part T cell receptor co-receptor CD8 relationship: RO:0002104 PR:000001004 ! has plasma membrane part CD4 molecule property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0000625 name: CD8-positive, alpha-beta T cell def: "A T cell expressing an alpha-beta T cell receptor and the CD8 coreceptor." [GOC:add, GOC:tfm, ISBN:0781735149] subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "CD8-positive, alpha-beta T lymphocyte" EXACT [] synonym: "CD8-positive, alpha-beta T-cell" EXACT [] synonym: "CD8-positive, alpha-beta T-lymphocyte" EXACT [] is_a: CL:0000791 {is_inferred="true"} ! mature alpha-beta T cell intersection_of: CL:0000791 ! mature alpha-beta T cell intersection_of: CL:4030046 PR:000001004 ! lacks_plasma_membrane_part CD4 molecule intersection_of: RO:0002104 PR:000025402 ! has plasma membrane part T cell receptor co-receptor CD8 relationship: CL:4030046 PR:000001004 ! lacks_plasma_membrane_part CD4 molecule relationship: RO:0002104 PR:000025402 ! has plasma membrane part T cell receptor co-receptor CD8 property_value: RO:0002175 NCBITaxon:9606 property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0000625" xsd:string {name="CD8-positive, alpha-beta T cell on CELLxGENE CellGuide"} property_value: terms:description "CD8-positive, alpha-beta T cells, also referred to as CD8+ T cells, are integral components of the body's adaptive immune system. They are characterized by the presence of the CD8 glycoprotein on their cell surface and the alpha and beta chains in their T cell receptors (TCRs). CD8+ T cells primarily function as cytotoxic T cells (CTLs), their specialized role in the immune response being to detect and eliminate cells presenting foreign or abnormal antigens on their surfaces.\nNaïve CD8+ T cells patrol the central lymphoid organs, checking peptide– MHC class I molecule complexes for the presence of their cognate antigen on antigen-presenting cells. Recognition of the foreign antigen by the TCR and interaction with MHC class I molecules triggers a series of events leading to the activation of the CD8+ T cell. Once activated, the CD8+ T cell divides, matures, and differentiates into effector T cells capable of destroying the target cells. This cytotoxic function is carried out by the release of substances like perforin and granzymes, which induce apoptosis, or programmed cell death, in the target cells.\nIn addition to their cytotoxic function, CD8+ T cells are known to release various cytokines, including interferon-gamma (IFN-γ) and tumor necrosis factor-alpha (TNF-α). These are potent mediators of the immune response and have roles in shaping the immune response and the inflammatory reaction. \nFollowing the resolution of an immune response, a small subset of activated CD8+ T cells persists as memory T cells, providing a quicker and more vigorous response upon subsequent encounters with the same antigen. These capabilities make CD8-positive, alpha-beta T cells indispensable for the body's defense against infections and malignant transformations.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1016/j.immuni.2011.07.010", xref="DOI:10.1038/s41577-021-00574-3", xref="DOI:10.3389/fimmu.2018.02692", xref="DOI:10.3389/fimmu.2018.02826"} [Term] id: CL:0000626 name: olfactory granule cell def: "A granule cell that has a soma located in an olfactory bulb granule cell layer. An olfactory granule cell is an interneuron that lacks an axon, makes reciprocal dendro-dendritic synapses with mitral cells and tufted cells and is involved in the fine spatio-temporal tuning of the responses of these principal olfactory bulb neurons to odors." [doi:10.1038/s41598-018-27692-8, GOC:mah] comment: Granule cells are the most abundant neuronal population in the olfactory bulb and are continuously renewed throughout life. {xref="doi:10.1038/s41598-018-27692-8"} subset: human_subset subset: mouse_subset synonym: "olfactory bulb granule cell" EXACT [doi:10.1038/s41598-018-27692-8] xref: ZFA:0001694 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000120 ! granule cell is_a: CL:1001434 ! olfactory bulb interneuron intersection_of: CL:0000120 ! granule cell intersection_of: RO:0002100 UBERON:0005378 ! has soma location olfactory bulb granule cell layer relationship: RO:0002100 UBERON:0005378 ! has soma location olfactory bulb granule cell layer relationship: RO:0002103 CL:1001502 ! synapsed by mitral cell relationship: RO:0002103 CL:1001503 ! synapsed by olfactory bulb tufted cell relationship: RO:0002120 CL:1001502 ! synapsed to mitral cell relationship: RO:0002120 CL:1001503 ! synapsed to olfactory bulb tufted cell relationship: RO:0002428 GO:0007608 ! involved in regulation of sensory perception of smell property_value: skos:prefLabel "olfactory granule cell" xsd:string [Term] id: CL:0000627 name: obsolete transporting cell def: "OBSOLETE. A cell involved in transporting nutrients, minerals, water, gases and other chemicals between cells for a variety of purposes including conveying nutrition to other tissues, removing waste products from the tissues, conveying gases for respiration, distributing heat and repelling invasion of foreign substances." [TAIR:sr] comment: Unsustainable functional grouping term of dubious utility. property_value: IAO:0000233 https://github.com/obophenotype/cell-ontology/issues/2990 is_obsolete: true [Term] id: CL:0000628 name: photosynthetic cell def: "A cell that can perform photosynthesis, in which carbohydrates are synthesized from carbon dioxide and water, using light as the energy source." [TAIR:sr] comment: see PMID:21177950, The making of a photosynthetic animal. is_a: CL:0000000 ! cell relationship: RO:0002215 GO:0015979 ! capable of photosynthesis [Term] id: CL:0000629 name: storage cell def: "A cell that is specialized to store a particular substance(s), which is(are) later released from the store for a particular purpose." [FB:ma] subset: human_subset subset: mouse_subset is_a: CL:0000325 ! stuff accumulating cell [Term] id: CL:0000630 name: supporting cell def: "A cell whose primary function is to support other cell types." [FB:ma, GOC:tfm] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "supportive cell" EXACT [] xref: BTO:0002315 xref: ZFA:0009387 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000000 ! cell property_value: skos:prefLabel "supporting cell" xsd:string [Term] id: CL:0000631 name: labyrinth supporting cell def: "Cells forming a framework supporting the organ of Corti. Specific cells are those of Claudius, Deiters and Hensen." [MESH:D007760] subset: human_subset subset: mouse_subset is_a: CL:0000630 ! supporting cell [Term] id: CL:0000632 name: hepatic stellate cell def: "A cell that is found in the perisinusoidal space of the liver that is capable of multiple roles including storage of retinol, presentation of antigen to T cells (including CD1d-restricted NKT cells), and upon activation, production of extracellular matrix components that can contribute to liver fibrosis. This activated state has a myofibroblast-like phenotype, though it's not clear in the literature if this is terminally differentiated. This cell type comprises approximately 8-15% of total cells in the liver." [GOC:dsd, http://en.wikipedia.org/wiki/Hepatic_stellate_cell, MESH:D055166, PMID:12808230, PMID:17239632, PMID:18222966, PMID:9302568] comment: Hepatic stellate cells are CD271-positive, desmin-positive, DDR-2-positive, GFAP-positive, synamin-positive, synaptophysin-positive, vimentin-positive, They are capable of producing angiotensin II, fibronectin, laminin, MMP-1, MMP-2, MMP-3, MMP-9, MMP-11, TGF-beta1, TIMP-1, TIMP-2, type I collagen, type III collagen, type IV collagen, and type VI collagen. subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "fat-storing cell" RELATED [] synonym: "hepatic perisinusoidal cell" EXACT [] synonym: "Ito cell" EXACT [] synonym: "lipocyte" RELATED [] synonym: "perisinusoidal cell" EXACT [] synonym: "vitamin A-storing cells" RELATED [PMID:12808230] xref: BTO:0002741 xref: CALOHA:TS-0452 xref: FMA:67763 xref: ZFA:0009279 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000057 ! fibroblast is_a: CL:0000327 ! extracellular matrix secreting cell intersection_of: CL:0002320 ! connective tissue cell intersection_of: BFO:0000050 UBERON:0002107 ! part of liver intersection_of: RO:0002104 PR:000007939 ! has plasma membrane part glial fibrillary acidic protein relationship: BFO:0000050 UBERON:0002107 ! part of liver relationship: RO:0002104 PR:000007939 ! has plasma membrane part glial fibrillary acidic protein property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/2d-ftu/liver-liver-lobule/v1.3/assets/2d-ftu-liver-liver-lobule.png" xsd:string {terms:licence="http://creativecommons.org/licenses/by/4.0/", xref="doi:10.48539/HBM889.CJPK.447"} property_value: RO:0002175 NCBITaxon:9606 property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0000632" xsd:string {name="hepatic stellate cell on CELLxGENE CellGuide"} property_value: terms:description "Hepatic stellate cells (HSCs) are a unique cell type found in the liver, residing in the space between the sinusoidal endothelial cells and the hepatocytes, known as the space of Disse. Despite constituting only 5-8% of the total number of liver cells, they play a significant role in the maintenance of liver health. They have a star-shaped (stellate) structure, hence their name and their principal function is the storage of vitamin A in their cytoplasm as retinyl esters.\nHSCs become highly active when the liver is damaged or diseased. They play a crucial role in the liver's response to injury and wound-healing process, converging into myofibroblasts, the cells responsible for scar tissue formation (fibrosis). They are also involved in maintaining the extracellular matrix balance by producing matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs), which break down and inhibit the breakdown of collagen respectively. HSCs also play a part in regulating blood flow through the liver’s blood vessels, help fight infections, and are involved in interactions among different types of liver cells. Recent research has implicated them in regulating liver regeneration and in the development of liver cancer.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1002/hep4.1628", xref="DOI:10.1016/S0083-6729(06)75006-3", xref="DOI:10.1038/s41598-019-43759-6", xref="DOI:10.1172/JCI66369"} [Term] id: CL:0000633 name: Hensen cell def: "A tall supporting cell that is arranged in rows adjacent to the last row of outer phalangeal cells. This cell type constitutes the outer border of the organ of Corti." [GOC:tfm, ISBN:0721662544] subset: human_subset subset: mouse_subset synonym: "cell of Hensen" EXACT [] synonym: "external limiting cell of organ of Corti" EXACT [] synonym: "Hensen's cell" EXACT [] xref: FMA:79799 is_a: CL:0002490 ! organ of Corti supporting cell [Term] id: CL:0000634 name: Claudius cell def: "A cuboidal cell which along with Boettcher's cells form the floor of the external spiral sulcus, external to the organ of Corti." [GOC:tfm, ISBN:0721662544] subset: human_subset subset: mouse_subset synonym: "cell of Claudius" EXACT [] synonym: "external supporting cell of Claudius" RELATED [] xref: FMA:79802 is_a: CL:0002315 ! supporting cell of cochlea [Term] id: CL:0000635 name: Deiter's cell def: "The outer phalangeal cells of the organ of Corti. This cell holds the base of the hair cell in a cup-shaped depression." [GOC:tfm, http://www.britannica.com/EBchecked/topic/156177/Deiters-cell, ISBN:0721662544] subset: human_subset subset: mouse_subset synonym: "Deiters cell" EXACT [] synonym: "outer phalangeal cell" EXACT [] xref: FMA:75725 is_a: CL:0002165 ! phalangeal cell [Term] id: CL:0000636 name: Mueller cell def: "Astrocyte-like radial glial cell that extends vertically throughout the retina, with the nucleus are usually in the middle of the inner nuclear layer." [GOC:NV, PMID:21911394] subset: cellxgene_subset subset: eye_upper_slim subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "Muller cell" EXACT MISSPELLING [doi:10.21769/BioProtoc.4179] synonym: "Muller glia" EXACT [] synonym: "Müller cell" EXACT [] xref: BTO:0003064 xref: ZFA:0009280 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000681 ! radial glial cell is_a: CL:0009004 ! retinal cell relationship: BFO:0000050 UBERON:0000966 ! part of retina property_value: RO:0002175 NCBITaxon:9606 property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0000636" xsd:string {name="Mueller cell on CELLxGENE CellGuide"} property_value: terms:description "Mueller cells, also referred to as Műller glial cells, are a type of radial glial cell found specifically within the retina, the light-sensitive tissue lining the back interior surface of the eye. They derive their name from Heinrich Müller, who first described these cells in the mid-nineteenth century. These support cells contribute to maintaining the homeostasis and structural integrity of the retina. Mueller cells span the entire thickness of the retina, thus representing the only cell type that traverses all layers.\nMueller cells play a crucial role in maintaining the metabolic environment of retinal neurons and participating in the visual signal transduction. They have a unique organization and possess a wide range of processes, giving them direct contact with virtually every type of cell in the retina—including photoreceptors, bipolar cells, and ganglion cells. These cells actively uptake and recycle neurotransmitters, modulate chemical levels within the extracellular space, and are involved in potassium siphoning, thus supporting neuronal signaling. Due to these functions, they play a vital role in maintaining the physiological and functional stability of the retina.\nMoreover, Mueller cells are also responsible for maintaining the structural integrity of the retina. They serve as the retinal framework by providing structural support to neurons and blood vessels. They contribute to the formation and maintenance of the inner limiting membrane, comprising their end-feet at the vitreous surface. Additionally, they play an essential role during injury or disease, exhibiting reactive gliosis – a process where these cells undergo morphological and functional changes to aid in repair and protection from further damage. While their protective role is important, it's also worth noting that overactivation of Mueller cells may result in retinal scarring or degeneration, reinforcing their complex and delicate role in retinal health and disease.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1002/glia.22477", xref="DOI:10.1007/s10792-020-01477-3", xref="DOI:10.1016/j.preteyeres.2006.05.003", xref="DOI:10.1038/78774", xref="DOI:10.3389/fendo.2013.00048"} [Term] id: CL:0000637 name: chromophil cell of anterior pituitary gland def: "A cell that stains readily in the anterior pituitary gland." [GOC:tfm, ISBN:0618947256] subset: human_subset subset: mouse_subset xref: FMA:83089 is_a: CL:0000150 ! glandular secretory epithelial cell is_a: CL:0000166 ! chromaffin cell is_a: CL:0000167 ! peptide hormone secreting cell is_a: CL:0012001 ! neuron of the forebrain is_a: CL:2000004 ! pituitary gland cell intersection_of: CL:0000166 ! chromaffin cell intersection_of: BFO:0000050 UBERON:0002196 ! part of adenohypophysis relationship: BFO:0000050 UBERON:0002196 ! part of adenohypophysis property_value: skos:prefLabel "chromophil cell of anterior pituitary gland" xsd:string [Term] id: CL:0000638 name: acidophil cell of pars distalis of adenohypophysis def: "An acidophilic chromophil cell that of the anterior pituitary gland." [GOC:tfm] subset: human_subset subset: mouse_subset synonym: "acidophil cell of pars anterior of adenohypophysis" EXACT [] synonym: "acidophil of pars anterior of adenohypophysis" EXACT [] synonym: "acidophil of pars distalis of adenohypophysis" EXACT [] synonym: "pituitary alpha cell" EXACT [] xref: FMA:83093 is_a: CL:0000637 ! chromophil cell of anterior pituitary gland relationship: BFO:0000050 UBERON:0006964 ! part of pars distalis of adenohypophysis property_value: skos:prefLabel "acidophil cell of pars distalis of adenohypophysis" xsd:string [Term] id: CL:0000639 name: basophil cell of pars distalis of adenohypophysis def: "A basophilic chromophil cell that of the anterior pituitary gland." [GOC:tfm] subset: human_subset subset: mouse_subset synonym: "basophil cell of anterior lobe of hypophysis" EXACT [] synonym: "beta cell" RELATED [] synonym: "pituitary beta cell" RELATED [] xref: FMA:83094 is_a: CL:0000637 ! chromophil cell of anterior pituitary gland [Term] id: CL:0000641 name: chromophobe cell def: "A cell that is resistant to stains." [GOC:tfm] subset: human_subset subset: mouse_subset synonym: "chromophobic cell" EXACT [] xref: FMA:83626 is_a: CL:0000163 ! endocrine cell [Term] id: CL:0000642 name: folliculostellate cell def: "An agranular supporting cell of the anterior pituitary (adenohypophysis) that is characterized by a star-like morphology and ability to form follicles. Folliculostellate cells communicate with each other and with endocrine cells via gap junctions." [doi:10.23937/2572-407X.1510006, JB:jb, PMID:10495875, PMID:15961560] comment: Folliculostellate cells are a heterogeneous group of cells rather than a single cell type, with different morphology and gene expression profiles. Due to this heterogeneity, it is unclear if different properties that have been attributed to folliculostellate cells (pluripotent, proliferative, phagocytic) are common in all folliculostellate cells or limited to particular subsets. {xref="doi:10.23937/2572-407X.1510006", xref="PMID:34734454", xref="PMID:31620083", xref="PMID:18287078"} subset: human_subset subset: mouse_subset synonym: "folliculo-stellate cell" EXACT [doi:10.23937/2572-407X.1510006] synonym: "FS cell" RELATED OMO:0003000 [PMID:34734454] synonym: "FSC" RELATED OMO:0003000 [doi:10.23937/2572-407X.1510006] synonym: "pituitary folliculostellate cell" EXACT [PMID:34734454] synonym: "Sox2-positive stem cell" RELATED [PMID:34734454] xref: ZFA:0009281 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000630 ! supporting cell is_a: CL:2000004 ! pituitary gland cell relationship: BFO:0000050 UBERON:0002196 ! part of adenohypophysis property_value: skos:prefLabel "folliculostellate cell" xsd:string [Term] id: CL:0000644 name: Bergmann glial cell def: "Type of radial astrocyte in the cerebellar cortex that have their cell bodies in the Purkinje cell layer and processes that extend into the molecular layer, terminating with bulbous endfeet at the pial surface. Bergmann glia express high densities of glutamate transporters that limit diffusion of the neurotransmitter glutamate during its release from synaptic terminals. Besides their role in early development of the cerebellum, Bergmann glia are also required for the pruning or addition of synapses." [GOC:tfm, http://www.neurolex.org/wiki/Category\:Bergmann_Glial_Cell] subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "Bergmann astrocyte" EXACT [] synonym: "Bergmann glial cell of cerebellum" EXACT [] xref: FMA:54559 xref: ZFA:0009282 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0002603 ! astrocyte of the cerebellum relationship: BFO:0000050 UBERON:0002979 ! part of Purkinje cell layer of cerebellar cortex property_value: foaf:depiction Candelabrum:cell.jpg {dc:license="https://creativecommons.org/licenses/by-nc-nd/4.0/", xref="doi:10.3389/fnins.2020.00293"} property_value: RO:0002175 NCBITaxon:9606 property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0000644" xsd:string {name="Bergmann glial cell on CELLxGENE CellGuide"} property_value: terms:description "Bergmann glial cells, also known as Bergmann glia or Bergmann astrocytes, are specialized astrocytes located in the cerebellum, specifically in the Purkinje cell layer. They were discovered and named after the German histologist Karl Bergmann and are known for their characteristic morphology. Unique to Bergmann glial cells is their long, fibrous processes, which extend through the molecular layer to the cerebellar surface, aligning parallel to the Purkinje cells' dendrites. These extensions play a detailed role in the structural organization and function of the cerebellum.\nThe primary function of Bergmann glial cells is to support and nourish the adjacent neuronal cells, especially the Purkinje cells. Their strategic arrangements around synapses or nerve junctions also indicate their role in facilitating communication between neurons and in modulating synaptic plasticity. The glial cells remove excess neurotransmitters from the synaptic clefts and thus help maintain homeostasis. An additional important role of Bergmann glia is in the guided migration of granule cells during cerebellar development. This guidance is critical for the proper formation and arrangement of the cerebellar circuitry.\nIn addition to these roles, recent studies have revealed a vital function of Bergmann glial cells in maintaining the overall health and functioning of the cerebellum. In instances of cerebellar injury or disease, these cells respond proactively and change their morphology and activity, a process known as reactive gliosis. This response seems to protect and restore the neural circuits. However, aberrant activation of Bergmann glial cells has been associated with several neurodegenerative diseases and disorders, such as spinocerebellar ataxia, underscoring their significance in the pathobiology of the nervous system.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1002/jnr.10197", xref="DOI:10.1007/s12035-013-8405-y", xref="DOI:10.1016/S0074-7742(08)60530-9", xref="DOI:10.1038/nn1750", xref="DOI:10.1080/14734220600724569"} [Term] id: CL:0000645 name: pituicyte def: "A glial cell of astrocytic lineage with long processes running parallel to adjacent axons in the proximal infundibulum of the neurohypophysis. These processes form a three-dimensional network among the axons of the hypothalamic neurosecretory cells and are connected by gap junctions which provide for their metabolic coupling. This cell type constitutes most of the nonexcitable tissue in the neurohypophsis; function may include possibly acting as an intermediate in the modulation of oxytocin and vasopressin release. This cell type is highly variable in size and shape and commonly contain lipid droplets and deposits of lipochrome pigment." [http://en.wikipedia.org/wiki/Pituicyte, ISBN:0412046911, ISBN:0517223651, PMID:31915267] subset: human_subset subset: mouse_subset xref: BTO:0003793 xref: FMA:83503 is_a: CL:0012000 ! astrocyte of the forebrain is_a: CL:2000004 ! pituitary gland cell relationship: BFO:0000050 UBERON:0002198 ! part of neurohypophysis [Term] id: CL:0000646 name: basal cell def: "Undifferentiated; mitotic stem cell for other epithelial cell types; rounded or elliptical with little cytoplasm and few organelles; contain cytokeratin intermediate filament." [GOC:tfm, ISBN:0517223651] subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset xref: BTO:0000939 xref: FMA:62516 is_a: CL:0000036 ! epithelial fate stem cell property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0000647 name: multinucleated giant cell def: "A phagocytic syncytial cell formed by the fusion of macrophages, occurs in chronic inflammatory responses to persistent microorganism such as M.tuberculosis, component of granulomas. Sometimes used to refer to megakaryocytes." [GOC:add, GOC:tfm, ISBN:0702022918, ISBN:0702024783, PMID:33348900, Wikipedia:Giant_cell] comment: Role or process: Chronic infection, granulomatous inflammation. Consider also megakaryocyte (CL:0000556) as sometimes multinucleated giant cell is used to refer to this. subset: blood_and_immune_upper_slim subset: human_subset subset: mouse_subset synonym: "foreign body giant cell" EXACT [ISBN:0702022918, ISBN:0702024783] synonym: "Langerhans giant cell" EXACT [ISBN:0702022918, ISBN:0702024783] synonym: "macrophage polykaryon" EXACT [ISBN:0702022918, ISBN:0702024783] synonym: "MGC" RELATED OMO:0003000 [PMID:33348900] synonym: "multinucleate giant cell" EXACT [ISBN:0702022918, ISBN:0702024783] synonym: "syncytial giant cell" EXACT [ISBN:0702022918, ISBN:0702024783] xref: BTO:0003107 xref: FMA:83035 xref: MESH:D015726 is_a: CL:0000766 {is_inferred="true"} ! myeloid leukocyte is_a: CL:4052002 ! syncytial cell intersection_of: CL:0000766 ! myeloid leukocyte intersection_of: RO:0000053 PATO:0001908 ! has characteristic multinucleate intersection_of: RO:0000056 GO:0002432 ! participates in granuloma formation intersection_of: RO:0000056 GO:0002544 ! participates in chronic inflammatory response relationship: RO:0000056 GO:0002432 ! participates in granuloma formation relationship: RO:0000056 GO:0002544 ! participates in chronic inflammatory response relationship: RO:0002202 CL:0000235 ! develops from macrophage [Term] id: CL:0000648 name: kidney granular cell alt_id: CL:0000461 def: "A smooth muscle cell that synthesizes, stores, and secretes the enzyme renin. This cell type are located in the wall of the afferent arteriole at the entrance to the glomerulus. While having a different origin than other kidney smooth muscle cells, this cell type expresses smooth muscle actin upon maturation." [GOC:cvs, GOC:tfm, PMID:11457727] subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "JG cell" EXACT [] synonym: "juxtaglomerular cell" BROAD [] synonym: "renin secreting cell" EXACT [] xref: FMA:84138 xref: ZFA:0005238 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000154 ! protein secreting cell is_a: CL:0000192 ! smooth muscle cell is_a: CL:1000618 ! juxtaglomerular complex cell intersection_of: CL:0000151 ! secretory cell intersection_of: BFO:0000050 UBERON:0002113 ! part of kidney intersection_of: RO:0002215 GO:0002001 ! capable of renin secretion into blood stream relationship: RO:0002215 GO:0002001 ! capable of renin secretion into blood stream property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0000649 name: spinous cell of epidermis alt_id: CL:0002186 def: "A keratinocyte found within the stratum spinosum (prickle cell layer) of the epidermis, distinguished by numerous intercellular desmosomes, which give it a “prickly” or spiny appearance. Positioned above the mitotically active basal layer and beneath the granular layer, it contributes to the skin’s mechanical strength and barrier function, preventing water loss and pathogen entry. This cell expresses differentiation-specific keratins K1 and K10 in mice, unlike basal cells that express K5 and K14, and lacks the keratohyalin granules found in granular cells, marking its intermediate stage of epidermal differentiation." [GOC:tfm, ISBN:0721662544, ISBN:0815332181, PMID:21860392, PMID:32097634, WIKIPEDIA:Spinous_cell] subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "prickle cell of epidermis" EXACT [WIKIPEDIA:Spinous_cell] synonym: "spinous keratinocytes of epidermis" EXACT [PMID:32843640] xref: FMA:69059 is_a: CL:4052060 ! spinous cell is_a: CL:4052061 ! epidermal keratinocyte intersection_of: CL:4052060 ! spinous cell intersection_of: BFO:0000050 UBERON:0002026 ! part of stratum spinosum of epidermis relationship: BFO:0000050 UBERON:0002026 ! part of stratum spinosum of epidermis property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/2d-ftu/skin-epidermal-ridge/v1.2/assets/2d-ftu-skin-epidermal-ridge.png" xsd:string {terms:licence="http://creativecommons.org/licenses/by/4.0/", xref="doi:10.48539/HBM642.BMZS.772"} property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0000650 name: mesangial cell def: "A cell type that encapsulates the capillaries and venules in the kidney. This cell secretes mesangial matrix that provides the structural support for the capillaries." [GOC:tfm, http://www.copewithcytokines.de/cope.cgi?key=mesangial%20cells] comment: Do all of these cells really develop from some mesenchymal stem cell? subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "kidney mesangial cell" EXACT [] xref: BTO:0000853 xref: CALOHA:TS-0617 xref: FMA:70972 xref: MESH:D050527 xref: ZFA:0009283 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: BFO:0000002 is_a: CL:0002681 ! kidney cortical cell is_a: CL:1001318 ! renal interstitial pericyte relationship: BFO:0000050 UBERON:0002319 ! part of mesangium relationship: RO:0002202 CL:0000134 ! develops from mesenchymal stem cell property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0000650" xsd:string {name="mesangial cell on CELLxGENE CellGuide"} property_value: terms:description "Mesangial cells are specialized cells that primarily reside in the middle layer, or mesangium, of the renal glomerulus within the kidney. The primary function of mesangial cells is to maintain the structural stability and function of the glomerular capillary tuft. They achieve this by providing structural support to the capillary loops, controlling the surface area available for filtration in response to physiological alterations in blood pressure, and removing trapped material and proteins from the basement membrane, which otherwise could cause damage. Moreover, mesangial cells regulate the glomerular blood flow by contracting and relaxing, similar to smooth muscle cells. They also synthesize extracellular matrix components, including collagen and fibronectin, that form the structural framework of the glomerulus.\nBeyond their structural and regulatory roles, mesangial cells are involved in several immunologic functions. They express a variety of receptors that can recognize immune complexes and subsequently mediate an inflammatory reaction. Their role in the immune response includes the production of a variety of cytokines and growth factors, which make them a key cellular component in the progression of several renal diseases.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1007/BF00180754", xref="DOI:10.1038/s41581-021-00474-8", xref="DOI:10.1681/ASN.2019070724", xref="DOI:10.3389/fimmu.2022.1063497", xref="DOI:10.3389/fmed.2021.740527"} [Term] id: CL:0000651 name: obsolete mucous neck cell def: "OBSOLETE. A mucus-secreting cell, with numerous apical secretory vesicles containing mucins; nucleus are basally displaced; numerous at the neck of mucus secreting glands" [GOC:tfm] comment: duplicate term synonym: "neck cell" BROAD [] is_obsolete: true replaced_by: CL:0002181 [Term] id: CL:0000652 name: pinealocyte def: "This cell type produces and secretes melatonin and forms the pineal parenchyma. Extending from each cell body, which has a spherical, oval or lobulated mucleus, are one or more tortuous basophilic processes, containing parallel microtubules known as synaptic ribbons. These processes end in expanded terminal buds near capillaries or less, frequently, ependymal cells of the pineal recess. The terminal buds contain granular endoplasmic reticulum, mitochondria and electron-dense cored vesicles, which store monoamines and polypeptide hormones, release of which appears to require sympathetic innervation." [GOC:tfm, http://en.wikipedia.org/wiki/Pinealocyte, ISBN:0517223651, PMID:16687276] subset: cellxgene_subset subset: human_subset subset: mouse_subset xref: BTO:0001068 xref: FMA:83417 xref: ZFA:0009284 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000150 ! glandular secretory epithelial cell is_a: CL:0000163 ! endocrine cell is_a: CL:0000710 ! neurecto-epithelial cell is_a: CL:0002319 ! neural cell relationship: BFO:0000050 UBERON:0001905 ! part of pineal body relationship: RO:0002215 GO:0030187 ! capable of melatonin biosynthetic process property_value: skos:prefLabel "pinealocyte" xsd:string [Term] id: CL:0000653 name: podocyte def: "A specialized kidney epithelial cell, contained within a glomerulus, that contains \"feet\" that interdigitate with the \"feet\" of other podocytes." [GOC:tfm, https://doi.org/10.1101/2021.10.10.463829] subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "epithelial cell of visceral layer of glomerular capsule" BROAD [FMA:70967] synonym: "glomerular podocyte" EXACT [FMA:70967] synonym: "glomerular visceral epithelial cell" EXACT [] synonym: "kidney podocyte" EXACT [] synonym: "renal podocyte" EXACT [] xref: BTO:0002295 xref: FMA:70967 xref: ZFA:0009285 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0002522 ! renal filtration cell is_a: CL:1000450 ! epithelial cell of glomerular capsule intersection_of: CL:0000066 ! epithelial cell intersection_of: BFO:0000050 UBERON:0005751 ! part of glomerular visceral epithelium relationship: BFO:0000050 UBERON:0005751 ! part of glomerular visceral epithelium property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/2d-ftu/kidney-renal-corpuscle/v1.2/assets/2d-ftu-kidney-renal-corpuscle.png" xsd:string {terms:licence="http://creativecommons.org/licenses/by/4.0/", xref="doi:10.48539/HBM778.SHGJ.294"} property_value: RO:0002175 NCBITaxon:9606 property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0000653" xsd:string {name="podocyte on CELLxGENE CellGuide"} property_value: seeAlso "https://github.com/obophenotype/cell-ontology/issues/1460" xsd:string property_value: terms:description "Podocytes are highly specialized, terminally differentiated glomerular visceral epithelial cells that wrap around the capillaries in the kidneys. They play an essential role in kidney function, particularly in the filtration selectivity of the glomerulus. Each podocyte is characterized by a unique architecture with a large cell body, ‘major processes’ extending outwardly from the cell body and ‘foot processes’, also known as pedicels, which surround. the glomerular capillary loops\nPodocytes represent the last barrier of the glomerular filtration membrane in the kidney. This barrier prevents the leakage of plasma proteins from the blood into the urine, hence maintaining protein homeostasis in the body. The foot processes of the podocytes interdigitate with those from neighboring cells. The cell-cell junctions between the foot processes, the slit-diaphragms, are thought to create a molecular sensor of renal filtration that prevents the passage of macromolecules while allowing water and small solutes to pass.\nPodocytes also contribute to the glomerular basement membrane by secreting collagen and maintain glomerular endothelial cell fenestration by secreting VEGFA. They have been shown to play a role in inducing cytoskeletal regulation, cell adhesion, and inflammatory response, consistent with their essential function in the kidney. \nThe importance of podocytes is further emphasized by the effects of their damage or loss. Abnormalities in podocytes often result in severe kidney diseases (podocytopathies), including focal segmental glomerulosclerosis (FSGS) and minimal change disease (MCD). Injury to the podocytes can result in \"effacement\" or flattening of foot processes, leading to increased permeability of the filtration barrier and proteinuria (an excess of serum protein in urine) which is a common symptom of kidney diseases.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1038/s41467-022-33748-1", xref="DOI:10.1038/s41572-020-0196-7", xref="DOI:10.1146/annurev-physiol-020911-153238", xref="DOI:10.1159/000481633", xref="DOI:10.3389/fcell.2021.771931"} [Term] id: CL:0000654 name: primary oocyte def: "A primary oocyte is an oocyte that has not completed female meosis I." [GOC:tfm, ISBN:0721662544] subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "primary oogonium" RELATED [] xref: BTO:0000512 xref: FMA:18645 is_a: CL:0000023 {is_inferred="true"} ! oocyte intersection_of: CL:0000023 ! oocyte intersection_of: CL:4030044 GO:0051321 ! has_not_completed meiotic cell cycle relationship: CL:4030044 GO:0051321 ! has_not_completed meiotic cell cycle relationship: RO:0002202 CL:0000024 ! develops from oogonial cell property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0000655 name: secondary oocyte def: "A secondary oocyte is an oocyte that has not completed meiosis II." [GOC:tfm, ISBN:0721662544] subset: human_subset subset: mouse_subset synonym: "primary oogonium" RELATED [] xref: BTO:0003094 xref: FMA:18646 is_a: CL:0000023 {is_inferred="true"} ! oocyte intersection_of: CL:0000023 ! oocyte intersection_of: CL:4030044 GO:0007147 ! has_not_completed female meiosis II relationship: CL:4030044 GO:0007147 ! has_not_completed female meiosis II relationship: RO:0002202 CL:0000654 ! develops from primary oocyte [Term] id: CL:0000656 name: primary spermatocyte def: "A diploid cell that has derived from a spermatogonium and can subsequently begin meiosis and divide into two haploid secondary spermatocytes." [GOC:tfm, ISBN:0721662544] subset: human_subset subset: mouse_subset xref: BTO:0001115 xref: CALOHA:TS-2194 xref: FMA:72292 is_a: CL:0000017 ! spermatocyte is_a: CL:0000255 ! eukaryotic cell intersection_of: CL:0000017 ! spermatocyte intersection_of: RO:0000053 PATO:0001394 ! has characteristic diploid intersection_of: RO:0002215 GO:0007140 ! capable of male meiotic nuclear division relationship: RO:0000053 PATO:0001394 ! has characteristic diploid relationship: RO:0002215 GO:0007140 ! capable of male meiotic nuclear division [Term] id: CL:0000657 name: secondary spermatocyte def: "One of the two haploid cells into which a primary spermatocyte divides, and which in turn gives origin to spermatids." [GOC:tfm, ISBN:0721662544] subset: human_subset subset: mouse_subset xref: BTO:0000709 xref: CALOHA:TS-2195 xref: FBbt:00004941 {sssom:mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"} xref: FMA:72293 is_a: CL:0000017 ! spermatocyte is_a: CL:0000255 ! eukaryotic cell is_a: CL:0000413 ! haploid cell intersection_of: CL:0000017 ! spermatocyte intersection_of: RO:0000053 PATO:0001375 ! has characteristic haploid intersection_of: RO:0002215 GO:0007142 ! capable of male meiosis II relationship: RO:0002202 CL:0000656 ! develops from primary spermatocyte relationship: RO:0002215 GO:0007142 ! capable of male meiosis II [Term] id: CL:0000658 name: cuticle secreting cell def: "An epithelial cell that secretes cuticle." [GOC:tfm] subset: human_subset subset: mouse_subset is_a: CL:0000066 ! epithelial cell is_a: CL:0000327 ! extracellular matrix secreting cell [Term] id: CL:0000659 name: eggshell secreting cell def: "An extracellular matrix secreting cell that secretes eggshell." [GOC:tfm] subset: human_subset subset: mouse_subset is_a: CL:0000327 ! extracellular matrix secreting cell is_a: CL:0000500 ! follicular epithelial cell [Term] id: CL:0000660 name: glycocalyx secreting cell def: "An extracellular matrix secreting cell that secretes glycocalyx." [GOC:tfm] subset: human_subset subset: mouse_subset is_a: CL:0000327 ! extracellular matrix secreting cell [Term] id: CL:0000661 name: distal tip cell (sensu Nematoda) subset: human_subset subset: mouse_subset is_a: CL:0000422 ! mitogenic signaling cell [Term] id: CL:0000662 name: neuroglioblast (sensu Nematoda) is_a: CL:0000468 ! neuroglioblast (sensu Nematoda and Protostomia) [Term] id: CL:0000663 name: obsolete valve cell property_value: IAO:0000233 https://github.com/obophenotype/cell-ontology/issues/726 is_obsolete: true replaced_by: CL:1000147 [Term] id: CL:0000664 name: obsolete closable valve cell property_value: IAO:0000233 https://github.com/obophenotype/cell-ontology/issues/726 is_obsolete: true replaced_by: CL:1000147 [Term] id: CL:0000665 name: obsolete permanently open valve cell property_value: IAO:0000233 https://github.com/obophenotype/cell-ontology/issues/726 is_obsolete: true replaced_by: CL:1000147 [Term] id: CL:0000666 name: fenestrated endothelial cell def: "An endothelial cell that has small pores, or fenestrations, which allow for the efficient exchange of substances between the blood and surrounding tissues." [DOI:10.1007/978-3-211-99390-3_133] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "window cell" EXACT [] xref: ZFA:0009286 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000115 ! endothelial cell intersection_of: CL:0000115 ! endothelial cell intersection_of: RO:0000053 PATO:0002064 ! has characteristic fenestrated relationship: RO:0000053 PATO:0002064 ! has characteristic fenestrated property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0000666" xsd:string {name="fenestrated endothelial cell on CELLxGENE CellGuide"} property_value: terms:description "Fenestrated cells are specialized epithelial cells that are characterized by a distinctive structural feature, fenestrations or tiny pores, which allow an exchange of substances such as fluids, nutrients, and waste between blood vessels and the surrounding tissue environments. These cells are present in various types of epithelial tissues in the human body, including the intestinal tract, endocrine glands, and certain parts of the renal system. \nThere are multiple types of endothelial cell fenestrations. The most common type is found in systemic capillaries of the endocrine tissue (e.g., pancreatic islets), gastrointestinal mucosa, and renal peritubular capillaries. Here, the fenestrated cells have fenestrations in their peripheral cytoplasm with a unique thin and permeable diaphragm that provides a high degree of selectivity, blocking the passage of larger molecules while allowing the free movement of smaller ones. In contrast, other types of fenestrations, such as the discontinuous epithelium of the liver sinusoidal endothelial cells, do not have diaphragms. \nCharacteristically, fenestrated cells play a vital role in the filtering process of body systems. They are a key part of the glomeruli in the kidneys where blood is filtered under high pressure. The fenestrations present in the endothelial cells lining the capillaries of the glomerulus allow the free passage of water and small solute molecules towards the Bowman's capsule, leaving behind larger proteins and cells in the blood, thereby aiding in the filtration and waste removal process. \nIn the endocrine system, fenestrated cells in glandular capillaries allow the prompt release of hormones into the bloodstream. These cells have tightly clustered fenestrations which increase the surface area available for passive diffusion, improving the efficiency of hormone secretion. In villi of the small intestine, these cells increase absorption efficiency, permitting the exchange of water, electrolytes, and nutrients.\nOverall, fenestrated cells contribute immensely to important physiological processes of filtration, absorption, and secretion, primarily connecting our body's circulation system with the surrounding tissues and organs.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1002/ar.1092200109", xref="DOI:10.1016/0306-4522(86)90162-4", xref="DOI:10.1016/j.devcel.2012.11.003", xref="DOI:10.1038/s41467-022-31571-2", xref="DOI:10.1152/ajprenal.90601.2008"} [Term] id: CL:0000667 name: collagen secreting cell def: "An extracellular matrix secreting cell that secretes collagen." [GOC:tfm] subset: cellxgene_subset subset: human_subset subset: mouse_subset xref: ZFA:0009287 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000327 ! extracellular matrix secreting cell property_value: skos:prefLabel "collagen secreting cell" xsd:string [Term] id: CL:0000668 name: obsolete parenchymal cell def: "OBSOLETE: The cell characteristic of an organ, as distinguished from associated connective or supporting tissues." [ISBN:0471245208] comment: OBSOLETE: Term was made obsolete to avoid confusion with plant parenchymal cell. Cell type has a similar but slightly different meaning in botany (plants): see PO:0000074. xref: BTO:0002174 xref: FMA:84638 is_obsolete: true [Term] id: CL:0000669 name: pericyte alt_id: CL:0000184 def: "An elongated, contractile cell found wrapped about precapillary arterioles outside the basement membrane. Pericytes are present in capillaries where proper adventitia and muscle layer are missing (thus distingushing this cell type from adventitial cells). They are relatively undifferentiated and may become fibroblasts, macrophages, or smooth muscle cells." [GOC:dsd, GOC:tfm, ISBN:0721662544, MESH:D020286, PMID:16807374, PMID:17986482, PMID:20024907] comment: Pericytes are CD10-positive, CD13-positive, CD31-negative, CD45-negative, CD106-positive, CD117-negative, CD140-positive, CD144-negative, CD146-positive, CD271-positive, CD325-positive, NG2-positive, RGS5-positive, SMA-positive, and desmin-positive. A subpopulation is CD248-positive. They are also capable of producing angiopoietin 1, CXCL12, TGF-beta, and VEGF-A. subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "adventitial cell" RELATED [] synonym: "adventitial reticular cell" EXACT [] synonym: "ARC" EXACT [PMID:17986482] synonym: "cell of Rouget" EXACT [] synonym: "pericyte cell" EXACT [] synonym: "pericyte of Rouget" EXACT [] xref: BTO:0002441 xref: FMA:63174 xref: ZFA:0009112 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000183 ! contractile cell is_a: CL:0000630 ! supporting cell is_a: CL:0002320 ! connective tissue cell is_a: CL:0008034 ! mural cell property_value: RO:0002175 NCBITaxon:9606 property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0000669" xsd:string {name="pericyte on CELLxGENE CellGuide"} property_value: terms:description "Pericytes, also known as Rouget cells, are a type of cell embedded in the wall of small blood vessels such as capillaries and venules. Not only do these cells share a basement membrane with endothelial cells, but they also have a direct physical contact with them, forming the blood-brain and blood-retinal barrier. They are an essential component of the neurovascular unit, a structure critical for maintaining brain homeostasis and a consistent neural microenvironment.\nPericytes play a crucial role in the regulation of microvascular blood flow and permeability. They dynamically respond to changes in blood flow and can relax or contract like smooth muscle cells, thereby controlling capillary diameter and blood flow to the tissues. Moreover, pericytes contribute significantly to the regulation of endothelial cell proliferation and migration, implying their vital role in angiogenesis and the stability of blood vessels. Their ability to differentiate into multiple cell types, including fibroblasts, macrophages, and smooth muscle cells, reveals their importance in tissue repair and remodeling.\nFurthermore, pericytes have demonstrated functions in regulating immune and inflammatory responses. Pericytes also collaborate with endothelial cells in preserving the integrity of the blood-brain barrier, thus protecting the central nervous system from potential damage due to harmful substances and pathogens.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1007/978-1-60761-938-3_2", xref="DOI:10.1016/j.cjtee.2020.02.006", xref="DOI:10.1177/0271678X15610340", xref="DOI:10.3389/fncel.2019.00282", xref="DOI:10.3390/biomedicines11020600"} [Term] id: CL:0000670 name: primordial germ cell def: "A primordial germ cell is a diploid germ cell precursors that transiently exist in the embryo before they enter into close association with the somatic cells of the gonad and become irreversibly committed as germ cells." [GOC:tfm, PMID:1381289] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "gonocyte" EXACT [] synonym: "primitive germ cell" EXACT [] xref: FMA:70567 xref: ZFA:0009288 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000039 {is_inferred="true"} ! germ line cell is_a: CL:0000219 {is_inferred="true"} ! motile cell intersection_of: CL:0000039 ! germ line cell intersection_of: BFO:0000050 UBERON:0000922 ! part of embryo intersection_of: RO:0002215 GO:0048870 ! capable of cell motility relationship: BFO:0000050 UBERON:0000922 ! part of embryo [Term] id: CL:0000671 name: centripetally migrating follicle cell def: "A follicle cell that migrates from the dorso-anterior part of the oocyte associated follicular epithelium, in between the nurse cells and the oocyte, and participates in the formation of the operculum." [PMID:36807509] synonym: "centripetal follicle cell" EXACT [] xref: FBbt:00004906 {sssom:mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"} is_a: CL:0000477 ! follicle cell of egg chamber [Term] id: CL:0000672 name: obsolete tracheary element def: "Obsolete. Use PO:0000290 from Plant Ontology instead. A water conducting cell, tracheid or vessel member." [ISBN:0471245208] is_obsolete: true replaced_by: PO:0000290 [Term] id: CL:0000673 name: Kenyon cell def: "An intrinsic neuron of the mushroom body of arthropods and annelids. They have tightly packed, cytoplasm-poor cell bodies." [doi:10.1016/S1467-8039(03)00009-4] synonym: "globuli cell" RELATED [] synonym: "mushroom body intrinsic neuron" BROAD [] xref: FBbt:00003686 {sssom:mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"} is_a: CL:0000028 ! CNS neuron (sensu Nematoda and Protostomia) relationship: BFO:0000050 UBERON:0001058 ! part of mushroom body [Term] id: CL:0000674 name: interfollicle cell def: "A follicle cell that is part of the stalk connecting adjacent egg chambers." [PMID:36531940] synonym: "stalk cell" EXACT [] synonym: "stalk follicle cell" EXACT [] xref: FBbt:00004910 {sssom:mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"} is_a: CL:0000477 ! follicle cell of egg chamber [Term] id: CL:0000675 name: female gamete def: "A mature sexual reproductive cell of the female germline." [GOC:tfm] subset: human_subset subset: mouse_subset is_a: CL:0000021 {is_inferred="true"} ! female germ cell is_a: CL:0000300 ! gamete [Term] id: CL:0000676 name: cap cell subset: human_subset subset: mouse_subset xref: BTO:0001033 is_a: CL:0000378 ! supporting cell (sensu Nematoda and Protostomia) [Term] id: CL:0000677 name: gut absorptive cell def: "Cell of the intestinal epithelium with a brush border made up of many parallel packed microvilli; associated with absorption, particularly of macromolecules." [JB:jb] subset: cellxgene_subset subset: human_subset subset: mouse_subset xref: ZFA:0009289 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000255 ! eukaryotic cell relationship: BFO:0000050 UBERON:0001277 ! part of intestinal epithelium [Term] id: CL:0000678 name: commissural neuron def: "A neuron with soma location in the central nervous system that project its axon to the contralateral side of a central nervous system. This neuron can have its soma in the spinal cord, in the hemisphere of the brain, in the retina or in the ventral nerve cord of invertebrates." [PMID:17560562, PMID:31693445] comment: Historically, commissural neurons, particularly in the spinal cord, have been used as a model to understand axon guidance during development. {xref="PMID:33438755", xref="PMID:31514748", xref="PMID:27532244", xref="PMID:25960414"} subset: human_subset subset: mouse_subset is_a: CL:2000029 ! central nervous system neuron [Term] id: CL:0000679 name: glutamatergic neuron def: "A neuron that is capable of some neurotansmission by glutamate secretion." [] subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset xref: FBbt:00100291 {sssom:mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"} xref: WBbt:0006829 xref: ZFA:0009290 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000151 ! secretory cell is_a: CL:0000540 ! neuron intersection_of: CL:0000540 ! neuron intersection_of: RO:0002215 GO:0061535 ! capable of glutamate secretion, neurotransmission relationship: RO:0002215 GO:0061535 ! capable of glutamate secretion, neurotransmission property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "glutamatergic neuron" xsd:string [Term] id: CL:0000680 name: muscle precursor cell def: "A non-terminally differentiated cell that is capable of developing into a muscle cell." [GOC:add] subset: cellxgene_subset subset: human_subset subset: mouse_subset xref: ZFA:0009291 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0011026 ! progenitor cell intersection_of: CL:0011115 ! precursor cell intersection_of: RO:0002203 CL:0000187 ! develops into muscle cell relationship: RO:0002202 CL:0000222 ! develops from mesodermal cell relationship: RO:0002203 CL:0000187 ! develops into muscle cell property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0000680" xsd:string {name="muscle precursor cell on CELLxGENE CellGuide"} property_value: skos:prefLabel "muscle precursor cell" xsd:string property_value: terms:description "Muscle precursor cells, commonly referred to as myogenic progenitor cells or myoblasts, play a pivotal role in the intricate processes of muscle regeneration and development. As undifferentiated cells, they harbor the potential to evolve into distinct specialized cells, specifically the muscle cell or myocyte. Their crucial contribution lies in guiding the transformation of the mesodermal layer, one of the three primary germ cell layers in the early embryo, into fully developed skeletal muscle tissues during embryonic development.\nMuscle precursor cells are characterized by their proliferative capacity and rapid differentiation into mature myocytes. They fuse into myotubes, culminating in the formation of muscle fibers. Their responsiveness to signals such as insulin-like growth factors, transforming growth factor-β, and neural inputs enables precise control over their proliferation and differentiation. This regenerative capacity equips them with the ability to repair injured or damaged muscle tissue, a critical function in preserving muscle homeostasis and overall function. These cells also actively contribute to adaptive responses, such as muscle growth and strengthening, in reaction to factors like training or aging.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1089/ars.2007.1792", xref="DOI:10.1152/physrev.00061.2017", xref="https://www.sciencedirect.com/topics/engineering/muscle-precursor-cell"} [Term] id: CL:0000681 name: radial glial cell def: "A cell present in the developing CNS. Functions as both a precursor cell and as a scaffold to support neuronal migration." [GOC:dph] comment: Unlike that of mammals, the brain of adult teleost fish exhibits an intense and widespread neurogenic activity as a result of the persistence of\nradial glial cells acting as neural progenitors throughout life. subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "forebrain radial glial cell" NARROW [] xref: ZFA:0009292 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000125 ! glial cell relationship: RO:0002202 CL:0000710 ! develops from neurecto-epithelial cell property_value: skos:prefLabel "radial glial cell" xsd:string [Term] id: CL:0000682 name: M cell of gut def: "An absorptive cell of the gut epithelium that endocytoses microorganisms and intact macromolecules from the gut lumen and transports them to the subepithelial space where they are presented to antigen-presenting cells and lymphocytes." [GOC:jb, GOC:tfm] comment: Should double check and see if M cells are particular to a specific region. subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "M cell" BROAD [] synonym: "M-cell" EXACT [] synonym: "microfold cell" EXACT [] xref: BTO:0003600 xref: FMA:62929 xref: ZFA:0009293 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0002563 ! intestinal epithelial cell relationship: BFO:0000050 UBERON:0004693 ! part of Peyer's patch epithelium property_value: RO:0002175 NCBITaxon:9606 property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0000682" xsd:string {name="M cell of gut on CELLxGENE CellGuide"} property_value: terms:description "M cells, or microfold cells, of the gut are specialized epithelial cells found in the lining of the gut, specifically in the follicle-associated epithelium of mucosa-associated lymphoid tissue, where they function as sentries against toxins and pathogens. M cells are characterized by apical microfolds (hence their alternate name) which express unique adhesion molecules that enable them to sample the luminal macromolecules. \nOther morphological features that distinguish M cells from other intestinal mucosal cells include sparse microvilli and a reduced thickness of the glycocalyx, which permits adhesion while not hindering the transport of molecules. They also have unique intraepithelial invaginations on the basolateral side which are filled with macrophages and other immune cells that can process the engulfed macromolecules quickly. \nThese morphological characteristics enable M cells to serve a dual role in immune responses. They initiate the immune response by transporting antigens (such as toxic or pathogenic substances) across the epithelial layer to lymphocytes and antigen-presenting cells in the underlying lymphoid tissue. This specialized transport process is called 'transcytosis.' They also have specialized molecules like glycoprotein-2 for bacterial uptake. Simultaneously, M cells help maintain immune tolerance to food antigens and commensal bacteria, preventing unnecessary reactions to non-pathogenic substances and hypersensitivity conditions. While these functions are crucial for well-being, M cell dysfunction can lead to serious conditions like Crohn's disease and other inflammatory bowel diseases.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1038/nature08529", xref="DOI:10.1093/jb/mvv121", xref="DOI:10.1136/gut.47.5.735", xref="https://www.ncbi.nlm.nih.gov/books/NBK534232/", xref="https://www.sciencedirect.com/topics/medicine-and-dentistry/microfold-cell"} [Term] id: CL:0000683 name: ependymoglial cell def: "A cell that transports hormones from neurosecretory cells. This nerve cell is characterized by bipolar shape and endfeet that contact a basal lamina around blood vessels, and/or the pia mater or vitreous body of the eye and additionally contact the ventricular surface or sub-retinal space." [http://neurolex.org/wiki/Category\:Ependymoglial_Cell, JB:jb] subset: human_subset subset: mouse_subset synonym: "ependymal astrocyte" EXACT [] xref: MESH:D063928 xref: ZFA:0009294 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000065 ! ependymal cell [Term] id: CL:0000684 name: littoral cell of liver subset: human_subset subset: mouse_subset is_a: CL:0000077 ! mesothelial cell relationship: BFO:0000050 UBERON:0002107 ! part of liver [Term] id: CL:0000685 name: obsolete meristematic cell def: "Obsolete. Use PO:0004010 from Plant Ontology instead. A cell synthesizing protoplasm and producing new cells by division and with only a primary cell wall." [PO:0004010] is_obsolete: true replaced_by: PO:0004010 [Term] id: CL:0000686 name: cerebrospinal fluid secreting cell def: "A columnar/cuboidal epithelial cell that secretes cerebrospinal fluid." [GOC:tfm] subset: human_subset subset: mouse_subset xref: ZFA:0009295 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000710 ! neurecto-epithelial cell is_a: CL:1100001 ! secretory epithelial cell intersection_of: CL:0000151 ! secretory cell intersection_of: RO:0002215 GO:0033326 ! capable of cerebrospinal fluid secretion relationship: RO:0002202 CL:0000333 ! develops from migratory neural crest cell relationship: RO:0002215 GO:0033326 ! capable of cerebrospinal fluid secretion [Term] id: CL:0000687 name: R1 photoreceptor cell synonym: "R1 cell" EXACT [] xref: FBbt:00004213 {sssom:mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"} is_a: CL:0000488 ! visible light photoreceptor cell is_a: CL:2000019 ! compound eye photoreceptor cell relationship: BFO:0000050 UBERON:0000971 ! part of ommatidium [Term] id: CL:0000688 name: perijunctional fibroblast def: "A fibroblast-like cell that provides support at neuromuscular junctions in vertebrates and are localized outside the synaptic basal lamina." [JB:jb] subset: human_subset subset: mouse_subset xref: ZFA:0009296 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000057 ! fibroblast is_a: CL:0000630 ! supporting cell [Term] id: CL:0000689 name: myoendocrine cell def: "A cell with both myofibrils and secretory granules." [JB:jb] subset: human_subset subset: mouse_subset is_a: CL:0000163 ! endocrine cell [Term] id: CL:0000690 name: R2 photoreceptor cell synonym: "R2 cell" EXACT [] xref: FBbt:00004215 {sssom:mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"} is_a: CL:0000488 ! visible light photoreceptor cell is_a: CL:2000019 ! compound eye photoreceptor cell relationship: BFO:0000050 UBERON:0000971 ! part of ommatidium [Term] id: CL:0000691 name: stellate interneuron def: "Any interneuron that has characteristic some stellate morphology." [FBC:Autogenerated] subset: BDS_subset subset: human_subset subset: mouse_subset xref: ZFA:0009297 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000099 ! interneuron is_a: CL:0000122 ! stellate neuron intersection_of: CL:0000099 ! interneuron intersection_of: RO:0000053 PATO:0070010 ! has characteristic stellate morphology [Term] id: CL:0000692 name: terminal Schwann cell def: "A neuroglial cell of the peripheral nervous system inside the basal lamina of the neuromuscular junction providing chemical and physical support to the synapse." [JB:jb, PMID:16136171] subset: human_subset subset: mouse_subset synonym: "perisynaptic Schwann cell" EXACT [PMID:18803315] synonym: "Schwann cell" BROAD [] synonym: "teloglia" EXACT [PMID:18803315] synonym: "tSC" RELATED OMO:0003000 [PMID:18803315] xref: ZFA:0009298 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000630 ! supporting cell is_a: CL:0002376 ! non-myelinating Schwann cell [Term] id: CL:0000693 name: neurogliaform cell def: "An interneuron that has spider-like appearance with a small round soma, a large number (7-10) of short, smooth, or slightly beaded primary dendrites that give rise to only a few secondary branches, and a branched axon that establishes a dense axonal mesh with thin shafts." [JB:jb, PMID:17122314] subset: BDS_subset subset: human_subset subset: mouse_subset synonym: "neuroglioform cell" EXACT [PMID:3235828] synonym: "NGF cell" EXACT [PMID:18568015] synonym: "spiderweb cell" EXACT [] xref: ZFA:0009299 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000099 ! interneuron intersection_of: CL:0000099 ! interneuron intersection_of: RO:0000053 PATO:0070001 ! has characteristic neurogliaform morphology relationship: RO:0000053 PATO:0070001 ! has characteristic neurogliaform morphology [Term] id: CL:0000694 name: R3 photoreceptor cell synonym: "R3 cell" EXACT [] xref: FBbt:00004217 {sssom:mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"} is_a: CL:0000488 ! visible light photoreceptor cell is_a: CL:2000019 ! compound eye photoreceptor cell relationship: BFO:0000050 UBERON:0000971 ! part of ommatidium [Term] id: CL:0000695 name: Cajal-Retzius cell def: "A type of transient, early-born glutamatergic neuron located primarily in the marginal zone (future layer I) of the developing cerebral cortex and hippocampus in vertebrates. it is characterized by a bipolar morphology with an elongated soma, a single thick dendrite oriented toward the pial surface, and a long, thin axon that extends tangentially to form horizontal plexuses across the cortical surface. It is important for the multiple developmental processes including migration, dendritogenesis and synaptogenesis. It typically undergoes programmed cell death following cortical maturation with species- and region specific patterns of survival. In mice, it is predominantly observed in the hippocampal formation, particularly in the stratum lacunosum-moleculare and outer molecular layer of the dentate gyrus (van Bruggen et al., 2023). In contrast, in humans, a second morphologically distinct subpopulation emerges mid-gestation and persists postnatally, with surviving cells observed in the cortical sulci and the hippocampus." [PMID:10600995, PMID:34047341, PMID:36774666, PMID:37775311, PMID:9728912] comment: While previously called 'pioneer neurons' of the marginal zone, Cajal-Retzius cells are differentiated from pioneer neurons (which are Reln-negative) by their Reln-immunoreactivity. {xref="PMID:10600995"} subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "CR cells" EXACT [WikipediaVersioned:Cajal–Retzius_cell&oldid=1032081753] synonym: "Horizontal cells of Cajal" EXACT [WikipediaVersioned:Cajal–Retzius_cell&oldid=1032081753] xref: ZFA:0009300 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000679 ! glutamatergic neuron is_a: CL:0012001 ! neuron of the forebrain relationship: RO:0000053 PATO:0070006 ! has characteristic cortical bipolar morphology property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0000695" xsd:string {name="Cajal-Retzius cell on CELLxGENE CellGuide"} property_value: terms:contributor https://orcid.org/0000-0001-7258-9596 property_value: terms:description "Cajal-Retzius cells are unique, early-born neurons found within the developing cerebral cortex and hippocampus. They are named after Santiago Ramon y Cajal and Gustaf Retzius, who first discovered them independently in the late 19th century. These neurons are characterized by horizontally oriented bipolar or multipolar cell bodies, facilitating their function in structuring the architecture of the cortex.\nThe primary role of Cajal-Retzius cells is to mediate the correct formation of the cortical layers in the developing brain. They accomplish this chiefly through the secretion of the extracellular matrix protein Reelin, which interacts with receptors on migrating neurons to control neuronal migration and position. The Reelin signal provided by Cajal-Retzius cells is essential to establish the cortical plate, where new neurons arising from the ventricular zone accumulate and form the recognizable layered structure of the cortical region. Disruptions in Reelin signaling can lead to reeler-like phenotypes characterized by inversion of cortical layers, demonstrating the importance of these cells during normal brain development.\nIn addition to layer formation, Cajal-Retzius cells also play a role in synaptic plasticity, which is a key aspect of learning, memory, and cognitive function. It has been suggested that these cells are involved in establishing the first functional synapses in the developing cortex, providing initial neural network activity. Furthermore, they have been linked to the modulation of gamma-aminobutyric acid (GABA) trafficking, excitatory-inhibitory balance, and thus, the fine-tune of the neural network activity during early postnatal life. Despite their disappearance shortly after birth in rodents and during early adolescence in humans, Cajal-Retzius cells lay the groundwork for the structure and functionality of the brain's cortical region.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1016/S0166-2236(97)01164-8", xref="DOI:10.1038/nrn2009", xref="DOI:10.1111/j.1440-169X.2009.01102.x", xref="DOI:10.1155/2014/597395", xref="DOI:10.1523/JNEUROSCI.1407-14.2014"} [Term] id: CL:0000696 name: PP cell def: "A cell that stores and secretes pancreatic polypeptide hormone." [GOC:tfm, JB:jb, PMID:15153415] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "type F enteroendocrine cell" EXACT [] xref: FMA:62938 xref: FMA:83409 is_a: CL:0000164 ! enteroendocrine cell is_a: CL:0000167 ! peptide hormone secreting cell property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0000696" xsd:string {name="PP cell on CELLxGENE CellGuide"} property_value: terms:description "PP cells, also known as pancreatic polypeptide cells (and previously called F cells or gamma cells), are enteroendocrine cells predominantly found in the islets of Langerhans in the head of the pancreas. They are one of the four main endocrine cell types present in the pancreatic islets, along with type A, B and D cells. PP cells are notable for their production of pancreatic polypeptide, an anorexigenic hormone that modulates food intake and energy homeostasis. \nBy secreting pancreatic polypeptide, PP cells play a significant role in the management of both digestive and appetite regulation. Upon ingestion of food, there is a significant increase in the secretion of pancreatic polypeptide, which then reduces biliary secretion and helps slow down the movement of food through the digestive tract. This allows more time for digestion to take place and nutrients to be absorbed, promoting the efficient use of dietary intake. The pancreatic polypeptide further reduces appetite by interacting with the hypothalamus, the area of the brain responsible for control of hunger.\nGiven their important role in digestion, malfunction or damage to PP cells can lead to a disturbance in the digestive process and contribute to some disease conditions. For example, an overproduction of pancreatic polypeptide can result in conditions such as pancreatic tumors and diabetes. Conversely, an under secretion might contribute to obesity due to impaired dietary control. Furthermore, PP cells may also play a role in the body's energy balance, suggesting their implication in conditions related to energy metabolism.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1016/j.febslet.2014.07.005", xref="DOI:10.1016/j.mce.2015.06.028", xref="DOI:10.1038/s41580-020-00317-7", xref="DOI:10.1210/jc.2003-030630", xref="DOI:10.1369/00221554155835"} [Term] id: CL:0000697 name: R4 photoreceptor cell synonym: "R4 cell" EXACT [] xref: FBbt:00004219 {sssom:mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"} is_a: CL:0000488 ! visible light photoreceptor cell is_a: CL:2000019 ! compound eye photoreceptor cell relationship: BFO:0000050 UBERON:0000971 ! part of ommatidium [Term] id: CL:0000698 name: obsolete paraganglial cell is_obsolete: true [Term] id: CL:0000699 name: paraganglial type 1 cell def: "A type of glomus or chief cell, is sensitive to hypoxia and produce catecholamines." [GOC:tfm] subset: human_subset subset: mouse_subset is_a: CL:0000165 ! neuroendocrine cell [Term] id: CL:0000700 name: dopaminergic neuron def: "A neuron that releases dopamine as a neurotransmitter." [GOC:dhill] subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "dopaminergic cell" EXACT [] xref: BTO:0004032 xref: FBbt:00005131 {sssom:mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"} xref: FMA:84787 xref: MESH:D059290 xref: WBbt:0006746 xref: ZFA:0009301 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:4033050 ! catecholaminergic neuron intersection_of: CL:0000540 ! neuron intersection_of: RO:0002215 GO:0061527 ! capable of dopamine secretion, neurotransmission relationship: RO:0002215 GO:0061527 ! capable of dopamine secretion, neurotransmission property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "dopaminergic neuron" xsd:string [Term] id: CL:0000701 name: paraganglia type 2 cell def: "Supports paraganglial type 1 cell." [JB:jb] subset: human_subset subset: mouse_subset is_a: CL:0000630 ! supporting cell [Term] id: CL:0000702 name: R5 photoreceptor cell synonym: "R5 cell" EXACT [] xref: FBbt:00004221 {sssom:mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"} is_a: CL:0000488 ! visible light photoreceptor cell is_a: CL:2000019 ! compound eye photoreceptor cell relationship: BFO:0000050 UBERON:0000971 ! part of ommatidium [Term] id: CL:0000703 name: sustentacular cell def: "Cell that provides some or all mechanical, nutritional and phagocytic support to their neighbors." [JB:jb] subset: human_subset subset: mouse_subset xref: BTO:0002315 xref: ZFA:0009302 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000630 ! supporting cell [Term] id: CL:0000704 name: endothelial tip cell def: "A specialized endothelial cell that senses extracellular signals and guides the directed growth of blood vessels." [PMID:15376331] subset: cellxgene_subset subset: human_subset subset: mouse_subset xref: ZFA:0009303 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000071 ! blood vessel endothelial cell property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0000704" xsd:string {name="endothelial tip cell on CELLxGENE CellGuide"} property_value: terms:description "Endothelial tip cells are a specialized type of cell that play a crucial role in angiogenesis, the formation of new blood vessels from the existing vasculature. These cells are located at the ends of growing capillary sprouts, their position giving them the term \"tip\" cells. \nEndothelial tip cells are characterized by a number of attributes which facilitate them to lead the way in angiogenesis: They have a highly dynamic, large, and polarized shape, and they extend numerous long and mobile filopodia, or finger-like projections, which continuously probe the extracellular microenvironment for cues that control the growth and movement of the cells. The filopodia are equipped with several receptors, including Vascular Endothelial Growth Factor Receptor (VEGFR) -2 and -3, which respond to guidance signals during angiogenesis. Their distinctive morphology with a broad leading edge and small cell body trailing behind helps in efficiently moving in the right direction responding to cues.\nThe function of endothelial tip cells is fundamental to the angiogenesis process. Guiding the sprouting vessel, they direct the subsequent proliferation and migration of the stalk cells, which follow the tip cells and form the body of the sprout. These tip cells do not proliferate, but instead, dictate the division of stalk cells, leading to the elongation of the sprout. They also help in lumen formation. The guidance and sprouting decisions of endothelial tip cells are critical for creating a functional and efficient network of vessels that can appropriately supply oxygen and nutrients to tissues. Notably, tip cells play a role in pathological conditions such as tumor angiogenesis and eye diseases, making them an important area of research in cell biology and medicine.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1016/j.devcel.2021.06.021", xref="DOI:10.1016/j.semcdb.2014.04.009", xref="DOI:10.1038/nrclinonc.2009.64", xref="DOI:10.1101/cshperspect.a006569"} [Term] id: CL:0000705 name: R6 photoreceptor cell synonym: "R6 cell" EXACT [] xref: FBbt:00004223 {sssom:mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"} is_a: CL:0000488 ! visible light photoreceptor cell is_a: CL:2000019 ! compound eye photoreceptor cell relationship: BFO:0000050 UBERON:0000971 ! part of ommatidium [Term] id: CL:0000706 name: choroid plexus epithelial cell alt_id: CL:1000430 def: "A specialized ependymal cell that is part of the choroid plexus epithelium, responsible for producing cerebrospinal fluid (CSF) by selectively filtering and modifying blood plasma components before secreting it into the brain and spinal cord. This cell is characterized by a brush border on its apical surface, which enhances the secretion of CSF." [GOC:add, GOC:tfm, JB:jb, PMID:15561411, PMID:9550134] comment: A choroid plexus epithelial cell possesses non-motile 9+0 cilia. While these cilia can exhibit transient motility during development, they generally do not contribute significantly to the directional flow of cerebrospinal fluid (CSF). Instead, they are primarily involved in sensory functions. {xref="PMID:25729351"} subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "choroid plexus cell" BROAD [DOI:10.1101/2022.10.12.511898] synonym: "epithelial cell of choroid plexus" EXACT [] xref: FMA:70549 xref: ZFA:0009304 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000065 ! ependymal cell is_a: CL:0000239 ! brush border epithelial cell intersection_of: CL:0000065 ! ependymal cell intersection_of: BFO:0000050 UBERON:0003911 ! part of choroid plexus epithelium relationship: BFO:0000050 UBERON:0003911 ! part of choroid plexus epithelium relationship: RO:0002215 GO:0033326 ! capable of cerebrospinal fluid secretion property_value: RO:0002175 NCBITaxon:9606 property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0000706" xsd:string {name="choroid plexus epithelial cell on CELLxGENE CellGuide"} property_value: terms:date "2023-08-04T08:48:30Z" xsd:dateTime property_value: terms:description "The choroid plexus epithelial cell is one of the crucial cell types found in the choroid plexus, a capillary-rich tissue located in the brain's ventricles. These cells are distinctly cuboidal or columnar, organized in a monolayer pattern with tight junctions that form a barrier between the cerebrospinal fluid inside the ventricles and the blood circulating in the choroid plexus. The polarity of these cells is highly specialized. The apical (ventricular) side, facing the cerebrospinal fluid, is characterized by numerous microvilli and cilia, while the basolateral (vascular) side is located adjacent to the choroidal interstitium. \nThe main function of the choroid plexus epithelial cells is to produce cerebrospinal fluid, an essential fluid that provides mechanical protection, nutrient delivery, and waste removal to and from the brain and spinal cord. These cells actively transport ions, glucose, and other molecules from the blood into the ventricles, driving the osmotic movement of water and the formation of cerebrospinal fluid. The cerebrospinal fluid turnover rate is remarkably high, with the choroid plexus epithelial cells producing approximately 500 mL each day.\nAnother noteworthy function of choroid plexus epithelial cells is their role as a constituent of the blood-cerebrospinal fluid barrier. Their organized pattern and tightly connected structure play a key role in strictly controlling the entry of substances from the blood to the cerebrospinal fluid, thus protecting the central nervous system from potentially harmful substances and fluctuations in blood composition. As such, these cells also serve in the transport of certain molecules into the central nervous system and in the clearance of waste products from the cerebrospinal fluid. Emerging evidence also shows that these cells contribute to brain immune responses acting as immunological sentinels.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1038/nrn3921", xref="DOI:10.1093/jnen/nlv030", xref="DOI:10.1152/physrev.00004.2013", xref="DOI:10.1523/JNEUROSCI.3258-13.2013", xref="https://www.ncbi.nlm.nih.gov/books/NBK538156/#:~:text=The%20choroid%20plexus%20has%20a,canal%20of%20the%20spinal%20cord."} [Term] id: CL:0000707 name: R7 photoreceptor cell synonym: "R7 cell" EXACT [] xref: FBbt:00004225 {sssom:mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"} is_a: CL:0000494 ! UV sensitive photoreceptor cell is_a: CL:2000019 ! compound eye photoreceptor cell relationship: BFO:0000050 UBERON:0000971 ! part of ommatidium [Term] id: CL:0000708 name: leptomeningeal cell def: "Stromal cell that forms the internal covering of the vertebrate brain and produces ECM for this and the choroid plexus." [JB:jb] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "leptomemingeal cell" RELATED [] xref: ZFA:0009305 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000327 {is_inferred="true"} ! extracellular matrix secreting cell is_a: CL:0002319 ! neural cell intersection_of: CL:0000327 ! extracellular matrix secreting cell intersection_of: BFO:0000050 UBERON:0003210 ! part of blood-cerebrospinal fluid barrier relationship: BFO:0000050 UBERON:0003210 ! part of blood-cerebrospinal fluid barrier [Term] id: CL:0000709 name: R8 photoreceptor cell synonym: "R8 cell" EXACT [] xref: FBbt:00004227 {sssom:mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"} is_a: CL:0000488 ! visible light photoreceptor cell is_a: CL:2000019 ! compound eye photoreceptor cell relationship: BFO:0000050 UBERON:0000971 ! part of ommatidium [Term] id: CL:0000710 name: neurecto-epithelial cell def: "Epithelial cells derived from neural plate and neural crest." [GOC:tfm] comment: The term "neuroepithelial cell" is used to describe both this cell type and sensory epithelial cell (CL:0000098). subset: human_subset subset: mouse_subset synonym: "neuroepithelial cell" BROAD [] xref: BTO:0004301 xref: FMA:70557 is_a: CL:0000075 ! columnar/cuboidal epithelial cell is_a: CL:0002077 ! ecto-epithelial cell intersection_of: CL:0002077 ! ecto-epithelial cell intersection_of: RO:0002202 CL:0000133 ! develops from neurectodermal cell relationship: RO:0002202 CL:0000133 ! develops from neurectodermal cell property_value: skos:prefLabel "neurecto-epithelial cell" xsd:string [Term] id: CL:0000711 name: cumulus granulosa cell def: "Cumulus cell is a specialized granulosa cell that surrounds and nourishes the oocyte. This cell-type surrounds the fully-grown oocyte to form a cumulus-oocyte complex (abbr. COC). The terms cumulus oophorus cells, cumulus granulosa cells, cumulus oophorous granulosa cells, granulosa-cumulus cells are used to make a distinction between this cell and the other functionally different subpopulation of granulosa cells at the wall of the Graafian follicle." [GOC:tfm, http://www.copewithcytokines.org/cope.cgi?key=cumulus%20cells] subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "cumulus cell" EXACT [] xref: BTO:0002236 xref: MESH:D054885 is_a: CL:0000154 ! protein secreting cell is_a: CL:0000501 ! granulosa cell is_a: UBERON:0004120 ! mesoderm-derived structure relationship: RO:0002202 CL:4033084 ! develops from cuboidal granulosa cell property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0000712 name: stratum granulosum cell def: "Any epidermal cell that is part of some stratum granulosum of epidermis." [FBC:Autogenerated] subset: human_subset subset: mouse_subset is_a: CL:0000362 ! epidermal cell intersection_of: CL:0000362 ! epidermal cell intersection_of: BFO:0000050 UBERON:0002069 ! part of stratum granulosum of epidermis relationship: BFO:0000050 UBERON:0002069 ! part of stratum granulosum of epidermis [Term] id: CL:0000713 name: corona radiata cell subset: human_subset subset: mouse_subset is_a: CL:0000711 ! cumulus granulosa cell [Term] id: CL:0000715 name: embryonic crystal cell def: "A crystal cell that derives from the embryonic head mesoderm." [] xref: FBbt:00001690 {sssom:mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"} is_a: CL:0000392 ! crystal cell is_a: CL:0011008 ! embryonic hemocyte [Term] id: CL:0000716 name: lymph gland crystal cell def: "A crystal cell that derives from the larval lymph gland." [] is_a: CL:0000392 ! crystal cell is_a: CL:0000735 ! lymph gland hemocyte [Term] id: CL:0000717 name: obsolete fusimotor neuron def: "OBSOLETE. A subset of motor neurons that innervates intrafusal muscle fibers and has small diameter axons." [PMID:15582775] comment: Term merged into CL:0008037. property_value: IAO:0000233 https://github.com/obophenotype/cell-ontology/issues/1364 is_obsolete: true replaced_by: CL:0008037 [Term] id: CL:0000718 name: compound eye cone cell def: "A cell of an ommatidium that secretes lens materials." [doi:10.1017/CBO9780511818202.023, PMID:34343526] comment: Not to be confused with the Semper cells of the Semper organ found in gastropods. {xref="doi:10.1242/jcs.s3-105.71.331"} synonym: "cone cell (sensu Endopterygota)" RELATED [] synonym: "Semper cell" EXACT [] xref: FBbt:00004193 {sssom:mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"} is_a: CL:0000306 ! crystallin accumulating cell is_a: CL:0002319 ! neural cell relationship: BFO:0000050 UBERON:0000971 ! part of ommatidium [Term] id: CL:0000719 name: posterior cone cell (sensu Endopterygota) is_a: CL:0000718 ! compound eye cone cell [Term] id: CL:0000720 name: anterior cone cell (sensu Endopterygota) is_a: CL:0000718 ! compound eye cone cell [Term] id: CL:0000721 name: equatorial cone cell (sensu Endopterygota) is_a: CL:0000718 ! compound eye cone cell [Term] id: CL:0000722 name: cystoblast is_a: CL:0000255 ! eukaryotic cell is_a: CL:0000586 ! germ cell relationship: RO:0002162 NCBITaxon:6656 ! in taxon Arthropoda [Term] id: CL:0000723 name: somatic stem cell def: "A stem cell that can give rise to cell types of the body other than those of the germ-line." [GO:0048103] subset: cellxgene_subset subset: human_subset subset: mouse_subset xref: CALOHA:TS-2086 xref: MESH:D053687 xref: ZFA:0009307 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000034 ! stem cell intersection_of: CL:0000034 ! stem cell intersection_of: RO:0002215 GO:0048103 ! capable of somatic stem cell division relationship: RO:0002215 GO:0048103 ! capable of somatic stem cell division property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0000723" xsd:string {name="somatic stem cell on CELLxGENE CellGuide"} property_value: skos:prefLabel "somatic stem cell" xsd:string property_value: terms:description "Somatic stem cells, also known as adult stem cells, are undifferentiated cells found throughout the body post-embryonic development. They reside in specialized niches within tissues such as the bone marrow, brain, muscles, skin, and liver. Fundamentally, these cells possess the ability to self-renew, maintaining their numbers, and to generate differentiated cells that replace dying cells and repair damaged tissues. \nThe potency of somatic stem cells varies based on their tissue of origin. For instance, hematopoietic stem cells in the bone marrow exhibit multipotency, giving rise to all blood cell types. Conversely, muscle stem cells display unipotency, generating only muscle cells.\nSomatic stem cells respond to environmental signals that regulate their quiescence, activation, and differentiation states. In response to tissue injury, they proliferate and differentiate into specific mature cell types to replace lost or damaged cells. Intricate mechanisms ensure a delicate balance between self-renewal and differentiation, guiding tissue maintenance and repair without risking aberrant cell proliferation leading to tumor formation.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1016/j.stem.2011.10.004", xref="DOI:10.1159/000345615", xref="DOI:10.1186/s13287-019-1165-5", xref="DOI:10.15283/ijsc19127", xref="https://www.sciencedirect.com/topics/agricultural-and-biological-sciences/adult-stem-cell"} [Term] id: CL:0000724 name: heterocyst def: "A differentiated cell that functions as a site of nitrogen fixation under aerobic conditions." [MA:ma] xref: BTO:0000600 is_a: CL:0000520 ! prokaryotic cell is_a: CL:0000725 ! nitrogen fixing cell [Term] id: CL:0000725 name: nitrogen fixing cell def: "Any cell that is capable of some nitrogen fixation." [FBC:Autogenerated] subset: human_subset subset: mouse_subset is_a: CL:0000000 ! cell intersection_of: CL:0000000 ! cell intersection_of: RO:0002215 GO:0009399 ! capable of nitrogen fixation relationship: RO:0002215 GO:0009399 ! capable of nitrogen fixation [Term] id: CL:0000726 name: chlamydospore def: "An asexual 1-celled spore (primarily for perennation, not dissemination). Originates endogenously and singly within part of a pre-existing cell by the contraction of the protoplast. Possesses an inner secondary and often thickened hyaline or brown wall, usually impregnated with hydrophobic material." [GOC:tfm, ISBN:085199377X] comment: Considering obsoleting as sometimes used to refer to protozoans too. But reference indicates term was intended for fungus. is_a: CL:0000605 ! fungal asexual spore [Term] id: CL:0000727 name: obsolete primary pigment cell comment: Obsoleted as this level of precision is deemed unnecessary for CL. Consider using either the more general CL:0001658 or, if you need to refer to primary pigment cells specifically, a term from a taxon-specific ontology such as FBbt:00004231. property_value: IAO:0000233 https://github.com/obophenotype/cell-ontology/issues/1930 is_obsolete: true [Term] id: CL:0000728 name: obsolete secondary pigment cell comment: Obsoleted as this level of precision is deemed unnecessary for CL. Consider using either the more general CL:0001658 or, if you need to refer to secondary pigment cells specifically, a term from a taxon-specific ontology such as FBbt:00004232. property_value: IAO:0000233 https://github.com/obophenotype/cell-ontology/issues/1930 is_obsolete: true [Term] id: CL:0000729 name: obsolete tertiary pigment cell comment: Obsoleted as this level of precision is deemed unnecessary for CL. Consider using either the more general CL:0001658 or, if you need to refer to tertiary pigment cells specifically, a term from a taxon-specific ontology such as FBbt:00004233. property_value: IAO:0000233 https://github.com/obophenotype/cell-ontology/issues/1930 is_obsolete: true [Term] id: CL:0000730 name: leading edge cell def: "A cell at the front of a migrating epithelial sheet." [MA:ma] subset: human_subset subset: mouse_subset is_a: CL:0000066 ! epithelial cell [Term] id: CL:0000731 name: urothelial cell def: "A cell of a layer of transitional epithelium in the wall of the proximal urethra, bladder, ureter or renal pelvis, external to the lamina propria." [doi:10.1038/s41385-022-00565-0, GOC:tfm, MA:ma] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "urinary tract transitional epithelial cell" NARROW [] xref: FMA:84127 xref: ZFA:0009308 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000244 ! transitional epithelial cell intersection_of: CL:0000244 ! transitional epithelial cell intersection_of: BFO:0000050 UBERON:0000365 ! part of urothelium relationship: BFO:0000050 UBERON:0000365 ! part of urothelium property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0000731" xsd:string {name="urothelial cell on CELLxGENE CellGuide"} property_value: terms:description "Urothelial cells are a unique type of epithelial cell found lining the urinary tract system. They form the urothelium, a specialized, multi-layered epithelium that lines major portions of the urinary tract, including the renal pelvis, ureters, bladder, and the proximal part of the urethra. The distinct characteristic of urothelial cells is their ability to stretch and contract depending on the volume of liquid they contain - a feature that facilitates the essential role they play in maintaining the functionality and integrity of the urinary system.\nThe primary function of urothelial cells is to provide an impermeable barrier to urine, preventing the toxic components present in the urine from seeping back into the body's bloodstream. The urothelium consists of a superficial umbrella cell layer, 1–2 layers of intermediate cells, and a basal cell layer. The umbrella layer is composed of large, mostly binucleated cells that are covered in an asymmetrical unit membrane, the uroplakin plaques. These plaques function to seal the apical membrane of the bladder from the toxic and highly variable contents of urine. The lipid bilayer structure of uroplakin plaques has an exceptionally high concentration of uroplakins that contribute to the barrier function of the urothelium.\nBeyond their mechanical function, urothelial cells also play a role in sensing and signaling changes in the urinary system. They express a number of sensor molecules or respond to thermal, mechanical and chemical stimuli and can release chemical mediators. This allows them to act as sensory transducers because they detect changes in the filling state of the bladder and transmit this information to the nervous system. Moreover, these versatile cells contribute to the defense mechanism against urinary tract pathogens. They respond to bacterial infections by releasing chemical messengers, cytokines and chemokines, to attract immune cells, and also can engulf pathogens via endocytosis.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1002/nau.22195", xref="DOI:10.1038/ki.2009.73", xref="DOI:10.1038/ncpuro0672", xref="DOI:10.1038/s41579-020-0324-0", xref="DOI:10.1152/physrev.00041.2019"} [Term] id: CL:0000732 name: amoeboid cell subset: human_subset subset: mouse_subset is_a: CL:0000219 ! motile cell [Term] id: CL:0000733 name: lymph gland plasmatocyte def: "A plasmatocyte that derives from the larval lymph gland." [] is_a: CL:0000394 ! plasmatocyte is_a: CL:0000735 ! lymph gland hemocyte [Term] id: CL:0000734 name: obsolete embryonic gland plasmatocyte comment: Obsoleted as this is the same thing as 'embryonic plasmatocyte'. is_obsolete: true replaced_by: CL:0011009 [Term] id: CL:0000735 name: lymph gland hemocyte def: "A hemocyte that derives from the larval lymph gland." [doi:10.1242/dev.00702] xref: FBbt:00005917 {sssom:mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"} is_a: CL:0000387 ! hemocyte (sensu Arthropoda) [Term] id: CL:0000736 name: obsolete embryonic gland hemocyte comment: Obsoleted as this term probably resulted from a confusion. Hemocytes are either derived from the embryonic head mesoderm ("embryonic hemocytes") or from the larval lymph gland ("lymph gland hemocytes"), not from an "embryonic gland". is_obsolete: true replaced_by: CL:0011008 [Term] id: CL:0000737 name: striated muscle cell def: "Muscle cell which has as its direct parts myofilaments organized into sarcomeres." [GOC:tfm, ISBN:0721662544] subset: human_subset subset: mouse_subset xref: BTO:0002916 xref: CALOHA:TS-2157 xref: FMA:86936 xref: ZFA:0005784 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000187 ! muscle cell intersection_of: CL:0000187 ! muscle cell intersection_of: BFO:0000051 GO:0030017 ! has part sarcomere intersection_of: RO:0000053 PATO:0001410 ! has characteristic striated disjoint_from: CL:0008000 ! non-striated muscle cell relationship: BFO:0000051 GO:0030017 ! has part sarcomere relationship: RO:0000053 PATO:0001410 ! has characteristic striated property_value: skos:prefLabel "striated muscle cell" xsd:string [Term] id: CL:0000738 name: leukocyte def: "An achromatic cell of the myeloid or lymphoid lineages capable of ameboid movement, found in blood or other tissue." [GOC:add, GOC:tfm, ISBN:978-0-323-05290-0] subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "immune cell" RELATED [] synonym: "leucocyte" EXACT [] synonym: "white blood cell" EXACT [] xref: BTO:0000751 xref: CALOHA:TS-0549 xref: FMA:62852 xref: MESH:D007962 xref: NCIT:C12529 xref: ZFA:0009309 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: BFO:0000002 is_a: CL:0000219 ! motile cell is_a: CL:0000255 ! eukaryotic cell is_a: CL:0000988 {is_inferred="true"} ! hematopoietic cell is_a: CL:0002242 ! nucleate cell intersection_of: CL:0000988 ! hematopoietic cell intersection_of: RO:0000053 PATO:0002505 ! has characteristic nucleated intersection_of: RO:0002215 GO:0001667 ! capable of ameboidal-type cell migration relationship: BFO:0000050 UBERON:0002405 ! part of immune system relationship: RO:0002162 NCBITaxon:7742 ! in taxon Vertebrata relationship: RO:0002202 CL:0000037 ! develops from hematopoietic stem cell relationship: RO:0002215 GO:0001667 ! capable of ameboidal-type cell migration property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0000740 name: retinal ganglion cell def: "The set of neurons that receives neural inputs via bipolar, horizontal and amacrine cells. The axons of these cells make up the optic nerve." [GOC:dph] subset: cellxgene_subset subset: eye_upper_slim subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "gangliocyte" EXACT [] synonym: "ganglion cell of retina" EXACT [] synonym: "RGC" RELATED OMO:0003000 [doi:10.1038/s41598-020-66092-9] synonym: "RGCs" RELATED OMO:0003004 [doi:10.1038/s41598-020-66092-9] xref: BTO:0001800 xref: FMA:67765 xref: MESH:D012165 xref: ZFA:0009310 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: BFO:0000002 is_a: CL:0000540 ! neuron relationship: RO:0002100 UBERON:0000966 ! has soma location retina property_value: RO:0002175 NCBITaxon:9606 property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0000740" xsd:string {name="retinal ganglion cell on CELLxGENE CellGuide"} property_value: skos:prefLabel "retinal ganglion cell" xsd:string property_value: terms:description "Retinal ganglion cells (RGCs) are a type of neuron located near the inner surface of the retina, playing a critical role in the visual pathway. There are approximately 1 million RGCs in a typical human eye, each receiving inputs from multiple photoreceptor cells. As the only neurons in the retina that send information to the brain, they are the final output neurons of the vertebrate retina, and their axons constitute the majority of fibers in the optic nerve. \nThe primary function of RGCs is to receive visual information from photoreceptors via intermediary bipolar and amacrine cells, process it, and transmit it to the brain through their axons. The information that RGCs relay encompasses various aspects of the visual field, including color, contrast, brightness, and motion. A diverse population of RGCs, up to 30 distinct subtypes, each contributes to a specific aspect of vision, such as object motion, edge detection, or color contrast, illustrating the complexity of visual data processing that occurs already at the retinal level.\nRGCs also play a role in the regulation of circadian rhythms and the pupillary light reflex. Some RGCs contain the photopigment melanopsin and respond directly to light, separately from the retinal rod and cone cells found in the outer retina. These photosensitive RGCs are primarily involved in subconscious vision, particularly the regulation of circadian rhythms and the pupillary light reflex in response to changes in ambient light intensity. Hence, RGCs serve a highly specialized and diverse role in transmitting visual information and regulating light-dependent responses, view modalities, and key physiological processes.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1002/cne.10652", xref="DOI:10.1016/j.neuron.2019.07.016", xref="DOI:10.1038/nature16468", xref="DOI:10.1111/j.1444-0938.2010.00479.x", xref="DOI:10.1146/annurev-neuro-071714-034120"} [Term] id: CL:0000741 name: spinal accessory motor neuron def: "A motor neuron that is located in the cervical region of the spinal cord and selectively innervates the sternocleidmastoid or trapezius muscle. Unlike other motor neurons, they extend axons dorsally along lateral margins of the spinal cord." [PMID:16267219] subset: human_subset subset: mouse_subset synonym: "SACMN" EXACT [] xref: ZFA:0009311 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0008039 ! lower motor neuron [Term] id: CL:0000742 name: periarticular chondrocyte def: "A round chondrocyte that first differentiates in the late embryonic growth plate of bone." [PMID:15951842] subset: human_subset subset: mouse_subset xref: ZFA:0009312 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:1001607 ! articular chondrocyte [Term] id: CL:0000743 name: hypertrophic chondrocyte def: "A chondrocyte that is part of the hypertrophic cartilage zone. This cell is significantly enlarged and characterised by high expression of type X collagen (COL10A1) in both humans and mice. It actively coordinates endochondral ossification by mineralising the extracellular matrix, attracting blood vessels via angiogenic signalling, and mediating the transition from cartilage to bone - often by transdifferentiating into an osteoblast rather than undergoing apoptosis." [GO_REF:0000034, PMID:15951842, PMID:25321476, PMID:35179487] comment: Despite historical descriptions as 'terminally differentiated,' hypertrophic chondrocytes survive and transdifferentiate into osteoblasts. Genetic lineage tracing shows that hypertrophic chondrocytes do not simply undergo apoptosis but cross the cartilage–bone boundary, dedifferentiate into skeletal stem/progenitor cells, and then redifferentiate into osteoblasts and osteocytes. Single-cell RNA-seq further indicates that these chondrocyte-derived SSPCs are a major source of trabecular osteoblasts and marrow adipocytes. {xref="PMID:35179487"} subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset xref: ZFA:0009313 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000138 ! chondrocyte is_a: CL:0001035 ! bone cell intersection_of: CL:0000138 ! chondrocyte intersection_of: BFO:0000050 UBERON:0008187 ! part of hypertrophic cartilage zone relationship: BFO:0000050 UBERON:0008187 ! part of hypertrophic cartilage zone relationship: RO:0002215 GO:0001958 ! capable of endochondral ossification relationship: RO:0002292 PR:000005693 ! expresses collagen alpha-1(X) chain property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0000744 name: columnar chondrocyte def: "A columnar chondrocyte that differentiates in the late embryonic growth plate of bone. Columnar chondrocytes vigorously proliferate and form columns in the growth plate." [PMID:15951842] subset: human_subset subset: mouse_subset xref: ZFA:0009314 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000138 ! chondrocyte [Term] id: CL:0000745 name: retina horizontal cell def: "A neuron that laterally connects other neurons in the inner nuclear layer of the retina." [ISBN:0195088433] subset: cellxgene_subset subset: eye_upper_slim subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "HC" RELATED OMO:0003000 [doi:10.1038/s41598-020-66092-9] synonym: "HCs" RELATED OMO:0003004 [doi:10.1038/s41598-020-66092-9] synonym: "horizontal cell" EXACT [] xref: BTO:0004120 xref: ZFA:0009315 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: BFO:0000002 is_a: CL:0000099 ! interneuron relationship: RO:0002100 UBERON:0003902 ! has soma location retinal neural layer property_value: RO:0002175 NCBITaxon:9606 property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0000745" xsd:string {name="retina horizontal cell on CELLxGENE CellGuide"} property_value: terms:description "Retina horizontal cells are a specialized type of neuron found in the inner nuclear layer of the retina. They play a crucial role in the visual system by integrating and regulating the input from multiple photoreceptor cells, which sense and respond to light. Retina horizontal cells are so named due to their characteristic flat horizontal orientation, with their dendrites and axons coursing laterally in a plane parallel to the retinal surface.\nRetina horizontal cells are synaptically connected with photoreceptor cells (i.e., cones and rods) and bipolar cells. Their primary function is to facilitate the process of lateral inhibition, where an excited neuron reduces the activity of its neighbors. This capability is central to the phenomenon of \"contrast enhancement\" in visual perception, where the borders between light and dark areas are accentuated to better resolve images. Retina horizontal cells receive inputs from these neighboring photoreceptor cells and transmit their inhibitory output to not only photoreceptor cells but also bipolar cells, fine-tuning the responsiveness to changes in light intensity and differences in wavelengths.\nMoreover, retina horizontal cells play a substantial role in adaptation of retinal response to different light levels. In bright light conditions, they aid the reduction of the overall response to light stimuli, thus aiding in the prevention of photoreceptor saturation. These neurons are adept at adjusting the gain and thus the dynamic range of photoreceptors supporting the vision process under variable lighting conditions - from dim moonlight to bright sunshine. Therefore, retina horizontal cells contribute considerably to the adaptability, sharpness, and detail perception of our visual system.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1073/pnas.88.8.3310", xref="DOI:10.1113/JP274177", xref="DOI:10.1167/5.4.5", xref="DOI:10.1371/journal.pbio.1001107", xref="DOI:10.3389/fnana.2016.00077/full"} [Term] id: CL:0000746 name: cardiac muscle cell def: "Cardiac muscle cells are striated muscle cells that are responsible for heart contraction. In mammals, the contractile fiber resembles those of skeletal muscle but are only one third as large in diameter, are richer in sarcoplasm, and contain centrally located instead of peripheral nuclei." [GOC:mtg_cardiacconduct_nov11, GOC:tfm, ISBN:0323052908, PMID:22426062, PMID:4711263] comment: This class encompasses the muscle cells responsible for heart* contraction in both vertebrates and arthropods. The ultrastucture of a wide range of arthropod heart cells has been examined including spiders, horseshoe crabs, crustaceans (see Sherman, 1973 and refs therein) and insects (see Lehmacher et al (2012) and refs therein). According to these refs, the cells participating in heart contraction in all cases are transversely striated. Insects hearts additionally contain ostial cells, also transversely striated muscle cells, but which do not participate in heart contraction. subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "cardiac muscle fiber" EXACT [GO:0048739] synonym: "cardiac myocyte" EXACT [] synonym: "cardiocyte" BROAD [] synonym: "cardiomyocyte" EXACT [] synonym: "heart muscle cell" EXACT [] xref: BTO:0001539 xref: CALOHA:TS-0115 xref: FMA:14067 xref: MESH:D032383 xref: ZFA:0009316 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000737 ! striated muscle cell is_a: CL:0002494 ! cardiocyte intersection_of: CL:0000187 ! muscle cell intersection_of: BFO:0000050 UBERON:0007100 ! part of primary circulatory organ intersection_of: BFO:0000051 GO:0030017 ! has part sarcomere intersection_of: RO:0000053 PATO:0002478 ! has characteristic transversely striated intersection_of: RO:0000056 GO:0060047 ! participates in heart contraction relationship: RO:0000053 PATO:0002478 ! has characteristic transversely striated relationship: RO:0000056 GO:0060047 ! participates in heart contraction relationship: RO:0002202 CL:0000513 ! develops from cardiac muscle myoblast property_value: RO:0002175 NCBITaxon:9606 property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0000746" xsd:string {name="cardiac muscle cell on CELLxGENE CellGuide"} property_value: terms:description "Cardiac muscle cells, also known as cardiomyocytes or cardiac myocytes, are specialized cells that form the heart tissue. These cells are elongated, branched, and contain a single centrally located nucleus. Their anatomy is composed primarily of densely packed myofibrils, which are protein structures that consist of sarcomeres - the fundamental units of muscle contraction. Cardiac muscle cells are united at their ends through specialized junctions known as intercalated discs, which allow the heart to contract in a unified, powerful and rhythmic way.\nFunctionally, cardiac muscle cells are responsible for the heart's consistent pumping action that circulates blood throughout the body. Unlike most cells in the body, cardiac muscle cells spontaneously depolarize and generate action potentials without external stimulation. This unique trait stems from the presence of ion channels in the cells' membrane that allow a cyclic flow of ions across the membrane, which create the electrical impulses necessary for heart contraction. The spread of these electrical signals from one cardiac muscle cell to another - facilitated by the interconnected network made by the intercalated disks - results in a synchronized contraction of the heart muscle.\nUnlike skeletal muscle cells which can tire and need rest, cardiac muscle cells have to work ceaselessly throughout the entire lifespan, without the opportunity for rest, to ensure continuous circulation of blood. This is made possible through the high volume of mitochondria and a constant supply of oxygen from coronary circulation. In conclusion, cardiac muscle cells, through their unique structure and vital functionality, play a pivotal role in sustaining life by providing the means for blood to reach every cell in the body.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1016/j.ccep.2010.10.012", xref="DOI:10.1038/nrcardio.2016.203", xref="https://www.ncbi.nlm.nih.gov/books/NBK572070", xref="https://www.sciencedirect.com/topics/agricultural-and-biological-sciences/cardiac-muscle"} [Term] id: CL:0000747 name: cyanophore def: "A pigment cell derived from the neural crest. Contains blue pigment of unknown chemical composition in fibrous organelles termed cyanosomes. This gives a blue appearance." [SANBI:mhl] subset: human_subset subset: mouse_subset synonym: "blue chromatophore" RELATED [] xref: ZFA:0009317 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: BFO:0000002 is_a: CL:0000147 ! pigment cell is_a: CL:0000255 ! eukaryotic cell relationship: RO:0002202 CL:0005005 ! develops from cyanoblast [Term] id: CL:0000748 name: retinal bipolar neuron def: "A bipolar neuron found in the retina and having connections with photoreceptors cells and neurons in the inner plexiform layer." [PMID:14689473] subset: cellxgene_subset subset: eye_upper_slim subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "BC" RELATED OMO:0003000 [doi:10.1038/s41598-020-66092-9] synonym: "BCs" RELATED OMO:0003004 [doi:10.1038/s41598-020-66092-9] synonym: "BPs" RELATED OMO:0003004 [geo:GSE137537] xref: ZFA:0009318 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: BFO:0000002 is_a: CL:0000679 ! glutamatergic neuron is_a: CL:0008028 ! visual system neuron is_a: CL:0009004 ! retinal cell intersection_of: CL:0000540 ! neuron intersection_of: RO:0002100 UBERON:0001791 ! has soma location inner nuclear layer of retina relationship: RO:0002100 UBERON:0001791 ! has soma location inner nuclear layer of retina property_value: RO:0002175 NCBITaxon:9606 property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0000748" xsd:string {name="retinal bipolar neuron on CELLxGENE CellGuide"} property_value: terms:description "The retinal bipolar neuron is an integral part of the eye, specifically located within the retina. They are secondary neurons in the visual pathway and primarily serve to transmit information from photoreceptor cells, which respond to light, to retinal ganglion cells, which carry the signal to the brain. As such, these cells play a pivotal role in our ability to interpret and perceive visual information.\nThe structure of retinal bipolar neurons is unique and significant to their function. They are termed \"bipolar\" due to their morphology, having two poles: a single dendrite on one end and an axon on the other. The dendrite end connects to photoreceptor cells (rods or cones), while the axon end synapses with retinal ganglion cells. In the center of the dendrite and axon lies the cell body, which houses the cell's nucleus and other vital organelles.\nAt the functional level, retinal bipolar neurons can be categorized into ON and OFF types based on their response to light. 'ON' bipolar cells are depolarized (electrical potential across the cell membrane decreases) under light conditions, thereby increasing their rate of neurotransmitter release onto the downstream ganglion cells. In contrast, 'OFF' bipolar cells are hyperpolarized (electrical potential increases) in light conditions, decreasing their rate of neurotransmitter release. This dual system allows for a fine-tuned response and the ability to perceive differences in light intensity and contrast, thus creating a nuanced and detailed visual world.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1016/j.preteyeres.2008.03.003", xref="DOI:10.1016/j.ydbio.2021.09.005", xref="DOI:10.1017/S0952523810000209", xref="DOI:10.1038/nrn3783", xref="DOI:10.1126/science.201028"} [Term] id: CL:0000749 name: ON-bipolar cell def: "A bipolar neuron found in the retina and having connections with photoreceptors cells and neurons in the inner half of the inner plexiform layer. These cells depolarize in response to light stimulation of their corresponding photoreceptors." [PMID:14689473] subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset xref: ZFA:0009319 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000748 ! retinal bipolar neuron property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0000750 name: OFF-bipolar cell def: "A bipolar neuron found in the retina and having connections with photoreceptors cells and neurons in the outer half of the inner plexiform layer. These cells depolarize in response to light to dark transition." [PMID:14689473] subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset xref: ZFA:0009320 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000748 ! retinal bipolar neuron property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0000751 name: rod bipolar cell def: "A bipolar neuron found in the retina that is synapsed by rod photoreceptor cells but not by cone photoreceptor cells. These neurons depolarize in response to light." [GOC:tfm, PMID:14689473] comment: The marker set CDHR3, PRKCA-AS1 can identify the Human cell type http://purl.obolibrary.org/obo/CL_0000751 in the retina with a confidence of 0.929575519 (NS-Forest FBeta value). The marker set ENSG00000227681, C16orf74 can identify the Human cell type http://purl.obolibrary.org/obo/CL_0000751 in the retina with a confidence of 0.907779697 (NS-Forest FBeta value). {xref="https://doi.org/10.5281/zenodo.11165918"} subset: cellxgene_subset subset: human_subset subset: mouse_subset xref: FMA:67750 xref: ZFA:0009321 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000749 ! ON-bipolar cell relationship: RO:0002102 UBERON:0008925 ! axon synapses in sublaminar layer S4 relationship: RO:0002102 UBERON:0008926 ! axon synapses in sublaminar layer S5 relationship: RO:0002103 CL:0000604 ! synapsed by retinal rod cell relationship: RO:0015004 CLM:1001251 ! has characterizing marker set NS forest marker set of rod bipolar cell (Human retina). relationship: RO:0015004 CLM:1001266 ! has characterizing marker set NS forest marker set of rod bipolar cell (Human retina). property_value: RO:0002175 NCBITaxon:32443 {xref="PMID:38627529"} property_value: RO:0002175 NCBITaxon:9606 property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0000751" xsd:string {name="rod bipolar cell on CELLxGENE CellGuide"} property_value: terms:description "Rod bipolar cells constitute a significant component of the retinal neural network and play a pivotal role in signal transmission from rod photoreceptor cells to the other subsequent neuronal cells within the vision system. They belong to the category of interneurons, or connector cells, effectively conveying visual information under low light conditions. Non-mammalian and mammalian visual systems feature these cells serving as the primary conduit for scotopic (night vision) signals.\nThese cells harness their strategic position in the retina's inner nuclear layer to receive information from the rod photoreceptor cells and transmit it to amacrine and ganglion cells. Structurally, they are named bipolar due to their distinctive shape, with dendrites extending towards the outer retina to connect with rod cells, while their axons lead inwards to form synapses with ganglion and amacrine cells in the inner plexiform layer. Each rod bipolar cell tends to interface with several rod cells and several downstream neurons, forming intricate networks.\nBearing intricate dendritic trees, these cells can integrate responses from multiple rod cells efficiently, amplifying the retinal signal's strength. They employ glutamate, a type of neurotransmitter, to govern synaptic communication between photoreceptor cells and downstream neurons. This stratified arrangement of rod bipolar cells endows them with the capability to translate light signals into neural signals, predominantly maintaining the spatial and temporal resolution of our visual perception in dim lighting. They are key to our night vision and our ability to detect changes in our light environment.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1002/cne.23370", xref="DOI:10.1007/s004410000304", xref="DOI:10.1016/j.visres.2004.07.043", xref="DOI:10.1038/294592a0", xref="DOI:10.1038/nrn3783"} [Term] id: CL:0000752 name: cone retinal bipolar cell def: "A bipolar neuron found in the retina and having connections with cone photoreceptor cells and neurons in the inner plexiform layer." [PMID:14689473] comment: The marker set COL19A1, DOK5 can identify the Human cell type http://purl.obolibrary.org/obo/CL_0000752 in the retina with a confidence of 0.843060252 (NS-Forest FBeta value). The marker set DOK5, ST6GALNAC3 can identify the Human cell type http://purl.obolibrary.org/obo/CL_0000752 in the retina with a confidence of 0.782434709 (NS-Forest FBeta value). {xref="https://doi.org/10.5281/zenodo.11165918"} subset: cellxgene_subset subset: human_subset subset: mouse_subset xref: ZFA:0009322 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000748 ! retinal bipolar neuron intersection_of: CL:0000748 ! retinal bipolar neuron intersection_of: RO:0002103 CL:0000573 ! synapsed by retinal cone cell relationship: RO:0002103 CL:0000573 ! synapsed by retinal cone cell relationship: RO:0015004 CLM:1001241 ! has characterizing marker set NS forest marker set of cone retinal bipolar cell (Human retina). relationship: RO:0015004 CLM:1001261 ! has characterizing marker set NS forest marker set of cone retinal bipolar cell (Human retina). property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0000753 name: type 1 cone bipolar cell (sensu Mus) def: "An OFF-bipolar neuron found in the retina and having connections with cone photoreceptors cells and neurons in the outer half of the inner plexiform layer. The cell body of these cells is in the middle of the inner plexiform layer. The dendritic tree is stout and the axon terminates in sublamina 1. The axonal terminal is wide and has only a few varicosities." [PMID:14689473] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "DB1 cone bipolar cell" EXACT [] is_a: CL:0000752 ! cone retinal bipolar cell relationship: RO:0002102 UBERON:0008922 ! axon synapses in sublaminar layer S1 [Term] id: CL:0000754 name: type 2 cone bipolar cell (sensu Mus) def: "An OFF-bipolar neuron found in the retina and having connections with cone photoreceptors cells and neurons in the outer half of the inner plexiform layer. The dendritic tree is not well filled and the dendrites are more delicate than in type 1 cells. The axon terminal is bushier and exhibits a dense plexus of varicosities in the inner part of sublamina 1 (Ghosh et al., 2004). It can be differentiated from other retinal bipolar neurons by its expression of marker genes: Neto1, Lhx3 and Irx-6 (Shekhar, 2016)." [PMID:14689473, PMID:27565351] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "FMB cone bipolar cell" EXACT [] is_a: CL:0000752 ! cone retinal bipolar cell intersection_of: CL:0000748 {xref="PMID:27565351"} ! retinal bipolar neuron intersection_of: RO:0002292 PR:P50481 {xref="PMID:27565351"} ! expresses LIM/homeobox protein Lhx3 (mouse) intersection_of: RO:0002292 PR:Q8R4I7 {xref="PMID:27565351"} ! expresses neuropilin and tolloid-like protein 1 (mouse) intersection_of: RO:0002292 PR:Q9ER75 {xref="PMID:27565351"} ! expresses iroquois-class homeodomain protein IRX-6 (mouse) relationship: RO:0002102 UBERON:0008922 ! axon synapses in sublaminar layer S1 relationship: RO:0002292 PR:P50481 ! expresses LIM/homeobox protein Lhx3 (mouse) relationship: RO:0002292 PR:Q8R4I7 ! expresses neuropilin and tolloid-like protein 1 (mouse) relationship: RO:0002292 PR:Q9ER75 ! expresses iroquois-class homeodomain protein IRX-6 (mouse) [Term] id: CL:0000755 name: type 3 cone bipolar cell (sensu Mus) def: "An OFF-bipolar neuron found in the retina and having connections with cone photoreceptors cells and neurons in the outer half of the inner plexiform layer. The dendritic tree is delicate and the dendritic tips appear small when compared with type 1 cells. The axon terminal is stratified and restricted to sublamina 2 of the inner plexiform layer." [PMID:14689473] subset: human_subset subset: mouse_subset synonym: "DB2 cone bipolar cell" EXACT [] is_a: CL:0000752 ! cone retinal bipolar cell relationship: RO:0002102 UBERON:0008923 ! axon synapses in sublaminar layer S2 relationship: RO:0002103 CL:0000604 ! synapsed by retinal rod cell [Term] id: CL:0000756 name: type 4 cone bipolar cell (sensu Mus) def: "An OFF-bipolar neuron found in the retina and having connections with cone photoreceptors cells and neurons in the outer half of the inner plexiform layer. The cell has a diffuse axon terminal with varicosities in sublaminae 1 and 2 of the inner plexiform layer." [PMID:14689473] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "DB3 cone bipolar cell" EXACT [] is_a: CL:0000752 ! cone retinal bipolar cell relationship: RO:0002102 UBERON:0008923 ! axon synapses in sublaminar layer S2 relationship: RO:0002102 UBERON:0008924 ! axon synapses in sublaminar layer S3 relationship: RO:0002103 CL:0000604 ! synapsed by retinal rod cell [Term] id: CL:0000757 name: type 5 cone bipolar cell (sensu Mus) def: "An ON-bipolar neuron found in the retina and having connections with cone photoreceptors cells and neurons in the inner half of the inner plexiform layer. The axon terminal is restricted to sublamina 3 of the inner plexiform layer. It is narrowly stratified and branched. The dendritic tree has many delicate branches." [PMID:14689473] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "DB4 cone bipolar cell" EXACT [] is_a: CL:0000752 ! cone retinal bipolar cell relationship: RO:0002102 UBERON:0008924 ! axon synapses in sublaminar layer S3 [Term] id: CL:0000758 name: type 6 cone bipolar cell (sensu Mus) def: "An ON-bipolar neuron found in the retina and having connections with cone photoreceptors cells and neurons in the inner half of the inner plexiform layer. The cell has a loose, delicate axon terminal that opens in sublamina 3 of the inner plexiform layer and descends into sublamina 4." [PMID:14689473] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "DB5 cone bipolar cell" EXACT [] is_a: CL:0000752 ! cone retinal bipolar cell relationship: RO:0002102 UBERON:0008925 ! axon synapses in sublaminar layer S4 [Term] id: CL:0000759 name: type 7 cone bipolar cell (sensu Mus) def: "An ON-bipolar neuron found in the retina and having connections with cone photoreceptors cells and neurons in the inner half of the inner plexiform layer. The axon terminal is narrowly stratified and are found just below a calretinin-expressing band in sublamina 4 of the inner plexiform layer." [PMID:14689473] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "IMB cone bipolar cell" EXACT [] is_a: CL:0000752 ! cone retinal bipolar cell relationship: RO:0002102 UBERON:0008925 ! axon synapses in sublaminar layer S4 [Term] id: CL:0000760 name: type 8 cone bipolar cell (sensu Mus) def: "An ON-bipolar neuron found in the retina and having connections with cone photoreceptors cells and neurons in the inner half of the inner plexiform layer. This cell has the widest dendritic field and the widest axon terminal of all retinal bipolar cells. The axon terminal is delicate and stratified through sublaminae 4 and 5 of the inner plexiform layer." [PMID:14689473] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "DB6 cone bipolar cell" EXACT [] is_a: CL:0000752 ! cone retinal bipolar cell relationship: RO:0002102 UBERON:0008925 ! axon synapses in sublaminar layer S4 relationship: RO:0002102 UBERON:0008926 ! axon synapses in sublaminar layer S5 [Term] id: CL:0000761 name: type 9 cone bipolar cell (sensu Mus) def: "An ON-bipolar neuron found in the retina and having connections with cone photoreceptors cells and neurons in the inner half of the inner plexiform layer. The dendritic tree is wide and the dendritic convergence indicates cone selectivity. The axon terminal is sparsely branched and terminates in sublamina 5 of the inner plexiform layer." [PMID:14689473] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "BB cone bipolar cell" EXACT [] is_a: CL:0000752 ! cone retinal bipolar cell relationship: RO:0002102 UBERON:0008926 ! axon synapses in sublaminar layer S5 [Term] id: CL:0000762 name: nucleated thrombocyte def: "A nucleated blood cell involved in coagulation, typically seen in birds and other non-mammalian vertebrates." [GOC:add, GOC:tfm, PMID:16360205] comment: Note that this is a non-mammalian cell type. Use platelet ; CL:0000233 for thrombocytes (platelets) in mammals. subset: blood_and_immune_upper_slim subset: human_subset subset: mouse_subset xref: ZFA:0009323 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000226 ! single nucleate cell is_a: CL:0000763 {is_inferred="true"} ! myeloid cell intersection_of: CL:0000763 ! myeloid cell intersection_of: RO:0000053 PATO:0001407 ! has characteristic mononucleate intersection_of: RO:0002215 GO:0007596 ! capable of blood coagulation relationship: RO:0002202 CL:0000828 ! develops from thromboblast relationship: RO:0002215 GO:0007596 ! capable of blood coagulation [Term] id: CL:0000763 name: myeloid cell def: "A cell of the monocyte, granulocyte, mast cell, megakaryocyte, or erythroid lineage." [GOC:add] subset: cellxgene_subset subset: human_subset subset: mouse_subset xref: BTO:0001441 xref: CALOHA:TS-0647 xref: MESH:D022423 xref: ZFA:0009324 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: BFO:0000002 is_a: CL:0000255 ! eukaryotic cell is_a: CL:0000988 {is_inferred="true"} ! hematopoietic cell intersection_of: CL:0000988 ! hematopoietic cell intersection_of: RO:0002202 CL:0000049 ! develops from common myeloid progenitor relationship: RO:0002202 CL:0000049 ! develops from common myeloid progenitor property_value: skos:prefLabel "myeloid cell" xsd:string [Term] id: CL:0000764 name: erythroid lineage cell alt_id: CL:0002156 def: "A immature or mature cell in the lineage leading to and including erythrocytes." [GOC:add, GOC:tfm] comment: Note that in FMA erythropoietic cells are types of nucleated erythrocytes and thus don't include erythrocytes. subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "erythropoietic cell" EXACT [] xref: CALOHA:TS-0290 xref: FMA:62845 xref: FMA:83516 xref: ZFA:0009325 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000763 ! myeloid cell property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "erythroid lineage cell" xsd:string [Term] id: CL:0000765 name: erythroblast def: "A nucleated precursor of an erythrocyte that lacks hematopoietic lineage markers." [GOC:add, ISBN:0721601464, PMID:18174176] subset: blood_and_immune_upper_slim subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "normoblast" EXACT [] xref: BTO:0001571 xref: CALOHA:TS-0289 xref: FMA:83504 xref: MESH:D004900 xref: ZFA:0005237 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000764 {is_inferred="true"} ! erythroid lineage cell is_a: CL:0011026 ! progenitor cell intersection_of: CL:0000764 ! erythroid lineage cell intersection_of: BFO:0000051 GO:0005634 ! has part nucleus intersection_of: CL:4030045 GO:0005730 ! lacks_part nucleolus intersection_of: CL:4030046 PR:000001002 ! lacks_plasma_membrane_part CD19 molecule intersection_of: CL:4030046 PR:000001004 ! lacks_plasma_membrane_part CD4 molecule intersection_of: CL:4030046 PR:000001012 ! lacks_plasma_membrane_part integrin alpha-M intersection_of: CL:4030046 PR:000001020 ! lacks_plasma_membrane_part CD3 epsilon intersection_of: CL:4030046 PR:000001024 ! lacks_plasma_membrane_part neural cell adhesion molecule 1 intersection_of: CL:4030046 PR:000001083 ! lacks_plasma_membrane_part CD2 molecule intersection_of: CL:4030046 PR:000001084 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD8 alpha chain intersection_of: CL:4030046 PR:000001289 ! lacks_plasma_membrane_part membrane-spanning 4-domains subfamily A member 1 intersection_of: CL:4030046 PR:000001839 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD5 intersection_of: CL:4030046 PR:000001889 ! lacks_plasma_membrane_part CD14 molecule intersection_of: CL:4030046 PR:000002978 ! lacks_plasma_membrane_part lymphocyte antigen 6G intersection_of: RO:0002215 GO:0030218 ! capable of erythrocyte differentiation relationship: BFO:0000051 GO:0005634 ! has part nucleus relationship: CL:4030045 GO:0005730 ! lacks_part nucleolus relationship: CL:4030046 PR:000001002 ! lacks_plasma_membrane_part CD19 molecule relationship: CL:4030046 PR:000001004 ! lacks_plasma_membrane_part CD4 molecule relationship: CL:4030046 PR:000001012 ! lacks_plasma_membrane_part integrin alpha-M relationship: CL:4030046 PR:000001020 ! lacks_plasma_membrane_part CD3 epsilon relationship: CL:4030046 PR:000001024 ! lacks_plasma_membrane_part neural cell adhesion molecule 1 relationship: CL:4030046 PR:000001083 ! lacks_plasma_membrane_part CD2 molecule relationship: CL:4030046 PR:000001084 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD8 alpha chain relationship: CL:4030046 PR:000001289 ! lacks_plasma_membrane_part membrane-spanning 4-domains subfamily A member 1 relationship: CL:4030046 PR:000001839 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD5 relationship: CL:4030046 PR:000001889 ! lacks_plasma_membrane_part CD14 molecule relationship: CL:4030046 PR:000002978 ! lacks_plasma_membrane_part lymphocyte antigen 6G relationship: RO:0002202 CL:0000547 ! develops from proerythroblast relationship: RO:0002215 GO:0030218 ! capable of erythrocyte differentiation property_value: skos:prefLabel "erythroblast" xsd:string [Term] id: CL:0000766 name: myeloid leukocyte def: "A cell of the monocyte, granulocyte, or mast cell lineage." [GOC:add] subset: cellxgene_subset subset: human_subset subset: mouse_subset xref: ZFA:0009326 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000738 {is_inferred="true"} ! leukocyte is_a: CL:0000763 ! myeloid cell intersection_of: CL:0000738 ! leukocyte intersection_of: RO:0002202 CL:0000049 ! develops from common myeloid progenitor property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0000766" xsd:string {name="myeloid leukocyte on CELLxGENE CellGuide"} property_value: terms:description "Myeloid leukocytes are a group of immune cells descended from the myeloid lineage. The myeloid lineage constitutes a significant portion of the body's defense system, particularly against microbial pathogens and foreign substances. Myeloid leukocytes originate from hematopoietic stem cells located in the bone marrow. The commitment of a pluripotent hematopoietic stem cell into a myeloid progenitor cell represents the initiation step towards the development of myeloid leukocytes. Once differentiated, these cells contribute diversely to both the innate and adaptive immune responses in the body.\nMyeloid leukocytes include several distinct cell types based on functionality and structure, encompassing monocytes, macrophages, granulocytes (neutrophils, eosinophils, and basophils), and dendritic cells. Each cell type has specialized functions, occupying a unique role in the body's immune response. For instance, neutrophils are prolific phagocytes—cells that engulf and destroy pathogens—while eosinophils are instrumental in combating multicellular parasites and modulating allergic inflammatory responses. Monocytes, in addition to their phagocytic activities, can enter peripheral tissues and differentiate into macrophages or dendritic cells which are crucial for antigen presentation to T cells.\nAnother critical function of myeloid leukocytes is their involvement in tissue remodeling and repair. For example, macrophages not only play a key role in defending the body but also perform duties essential for wound healing, such as removing dead cells and stimulating tissue repair. In general, myeloid leukocytes participate in the removal of old and damaged cells, an essential process for maintaining good health and homeostasis. Through the orchestration of complex interactions and signal transductions, myeloid leukocytes provide the body with a robust defense system against foreign invaders and participate in maintaining the body's overall balance and function.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1016/j.biocel.2004.01.020", xref="https://www.ncbi.nlm.nih.gov/books/NBK563148/"} [Term] id: CL:0000767 name: basophil def: "Any of the immature or mature forms of a granular leukocyte that in its mature form has an irregularly shaped, pale-staining nucleus that is partially constricted into two lobes, and with cytoplasm that contains coarse, bluish-black granules of variable size. Basophils contain vasoactive amines such as histamine and serotonin, which are released on appropriate stimulation. A basophil is CD123-positive, CD193-positive, CD203c-positive, and FceRIa-positive." [GOC:add, GOC:amm, GOC:dsd, GOC:tfm, ISBN:0721601464, MESH:D001491, PMCID:PMC2626675, PMID:11927641, PMID:19741522, PMID:21236338, PMID:9933081] comment: Matures in the bone marrow and account for <1% of leukocytes in the peripheral blood, spleen, and bone marrow. Basophils are described as being CD11a-positive, CD11b-positive, CD13-positive, CD15-positive, CD18-positive, CD21-positive, CD25-positive, CD29-positive, CD35-positive, CD40-positive, CD40L-positive, CD44-positive, CD45R-negative, CD46-positive, CD49a-positive, CD49b-positive, CD49d-positive, CD55-positive, CD59-positive, CD62L-positive, CD63-positive, CD69-positive, CD90-negative, CD116-positive, CD117-negative, CD124-positive, CD125-positive, CD131-positive, CD161-positive, CD184-positive, CD191-positive, CD192-positive, CD197-positive, CD200R3-positive, CD218-positive, CD282-positive, CD284-positive, CD289-positive, CD290-positive, CD294-positive, natural killer cell receptor 2B4-positive, smad1-positive, CD3-negative, CD4-negative, CD7-negative, CD8-negative, CD14-negative, CD15-negative, CD16-negative, CD19-negative, CD20-negative, CD34-negative, CD36-negative, CD45R-negative, CD56-negative, CD57-negative, CD235a-negative, and GR1-negative. Transcription factors- GATA1-positive, PU.1-positive. subset: blood_and_immune_upper_slim subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "basophilic leucocyte" EXACT [] synonym: "basophilic leukocyte" EXACT [] synonym: "polymorphonuclear leucocyte" BROAD [] synonym: "polymorphonuclear leukocyte" BROAD [] xref: BTO:0000129 xref: CALOHA:TS-0073 xref: FMA:62862 is_a: CL:0000094 {is_inferred="true"} ! granulocyte intersection_of: CL:0000094 ! granulocyte intersection_of: RO:0002104 PR:000001344 ! has plasma membrane part ectonucleotide pyrophosphatase/phosphodiesterase family member 3 intersection_of: RO:0002104 PR:000001950 ! has plasma membrane part tumor necrosis factor ligand superfamily member 5 intersection_of: RO:0015015 PR:000001255 ! has high plasma membrane amount C-C chemokine receptor type 3 intersection_of: RO:0015015 PR:000001865 ! has high plasma membrane amount interleukin-3 receptor class 2 alpha chain intersection_of: RO:0015015 PR:000007431 ! has high plasma membrane amount high affinity immunoglobulin epsilon receptor subunit alpha relationship: RO:0002104 PR:000001344 ! has plasma membrane part ectonucleotide pyrophosphatase/phosphodiesterase family member 3 relationship: RO:0002104 PR:000001950 ! has plasma membrane part tumor necrosis factor ligand superfamily member 5 relationship: RO:0015015 PR:000001255 ! has high plasma membrane amount C-C chemokine receptor type 3 relationship: RO:0015015 PR:000001865 ! has high plasma membrane amount interleukin-3 receptor class 2 alpha chain relationship: RO:0015015 PR:000007431 ! has high plasma membrane amount high affinity immunoglobulin epsilon receptor subunit alpha property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0000768 name: immature basophil def: "Any of the immature forms of a basophil, in which basophilic specific granules are present but other phenotypic features of the mature form may be lacking." [GOC:add, ISBN:0721601464] subset: human_subset subset: mouse_subset synonym: "immature basophilic leucocyte" EXACT [] synonym: "immature basophilic leukocyte" EXACT [] is_a: CL:0000767 {is_inferred="true"} ! basophil intersection_of: CL:0000767 ! basophil intersection_of: BFO:0000051 CL:0017509 ! has part alobate nucleus relationship: BFO:0000051 CL:0017509 ! has part alobate nucleus relationship: RO:0002202 CL:0000830 ! develops from basophilic promyelocyte [Term] id: CL:0000769 name: basophilic metamyelocyte def: "A basophil precursor in the granulocytic series, being a cell intermediate in development between a basophilic myelocyte and a band form basophil. The nucleus becomes indented where the indentation is smaller than half the distance to the farthest nuclear margin; chromatin becomes coarse and clumped; specific granules predominate while primary granules are rare. Markers are CD11b-positive, CD15-positive, CD16-positive, CD24-positive, CD33-positive, and CD13-positive." [GOC:tfm, ISBN:0721601464, PMID:18466030] subset: human_subset subset: mouse_subset xref: FMA:84198 is_a: CL:0000768 {is_inferred="true"} ! immature basophil is_a: CL:0002192 ! metamyelocyte intersection_of: CL:0000768 ! immature basophil intersection_of: BFO:0000051 CL:0017507 ! has part reniform nucleus intersection_of: BFO:0000051 GO:0000792 ! has part heterochromatin intersection_of: BFO:0000051 GO:0042582 ! has part azurophil granule intersection_of: BFO:0000051 GO:0070820 ! has part tertiary granule intersection_of: RO:0002104 PR:000001012 ! has plasma membrane part integrin alpha-M intersection_of: RO:0002104 PR:000001456 ! has plasma membrane part alpha-(1,3)-fucosyltransferase 4 intersection_of: RO:0002104 PR:000001483 ! has plasma membrane part low affinity immunoglobulin gamma Fc region receptor III intersection_of: RO:0002104 PR:000001892 ! has plasma membrane part CD33 molecule intersection_of: RO:0002104 PR:000001932 ! has plasma membrane part signal transducer CD24 intersection_of: RO:0002104 PR:000002031 ! has plasma membrane part aminopeptidase N relationship: BFO:0000051 CL:0017507 ! has part reniform nucleus relationship: BFO:0000051 GO:0000792 ! has part heterochromatin relationship: BFO:0000051 GO:0042582 ! has part azurophil granule relationship: BFO:0000051 GO:0070820 ! has part tertiary granule relationship: RO:0002104 PR:000001456 ! has plasma membrane part alpha-(1,3)-fucosyltransferase 4 relationship: RO:0002104 PR:000001483 ! has plasma membrane part low affinity immunoglobulin gamma Fc region receptor III relationship: RO:0002104 PR:000001892 ! has plasma membrane part CD33 molecule relationship: RO:0002104 PR:000001932 ! has plasma membrane part signal transducer CD24 relationship: RO:0002104 PR:000002031 ! has plasma membrane part aminopeptidase N relationship: RO:0002202 CL:0000614 ! develops from basophilic myelocyte [Term] id: CL:0000770 name: band form basophil def: "A late basophilic metamyelocyte in which the nucleus is in the form of a curved or coiled band, not having acquired the typical multilobar shape of the mature basophil." [GOC:add, http://www.cap.org, ISBN:0721601464, PMID:18466030] subset: human_subset subset: mouse_subset is_a: CL:0000768 {is_inferred="true"} ! immature basophil intersection_of: CL:0000768 ! immature basophil intersection_of: BFO:0000051 CL:0017506 ! has part banded nucleus relationship: BFO:0000051 CL:0017506 ! has part banded nucleus relationship: RO:0002202 CL:0000769 ! develops from basophilic metamyelocyte [Term] id: CL:0000771 name: eosinophil def: "Any of the immature or mature forms of a granular leukocyte with a nucleus that usually has two lobes connected by one or more slender threads of chromatin, and cytoplasm containing coarse, round granules that are uniform in size and which can be stained by the dye eosin. Eosinophils are CD9-positive, CD191-positive, and CD193-positive." [GOC:add, GOC:amm, GOC:dsd, GOC:tfm, ISBN:0721601464, PMCID:PMC2626675, PMID:10914487, PMID:1662676] comment: Eosinophils are also CD14-negative, CD32-positive, CD44-positive, CD48-positive, CD69-positive, CD192-negative, MBP1-positive, MBP2-positive, TLR2-negative, TLR4-negative, and lineage-negative (B220, CD2, CD14, CD19, CD56, CD71, CD117, CD123, CD235a (glycophorin A), and TER119). The cytokines IL-3, IL-5, and GM-CSF are involved in their development and differentiation. Usually considered CD16-negative, CD16 is observed on eosinophilic metamyelocyte. subset: blood_and_immune_upper_slim subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "eosinocyte" EXACT [] synonym: "eosinophilic granulocyte" EXACT [] synonym: "eosinophilic leucocyte" EXACT [] synonym: "eosinophilic leukocyte" EXACT [] synonym: "polymorphonuclear leucocyte" BROAD [] synonym: "polymorphonuclear leukocyte" BROAD [] xref: BTO:0000399 xref: CALOHA:TS-0279 xref: FMA:62861 xref: MESH:D004804 is_a: CL:0000094 {is_inferred="true"} ! granulocyte intersection_of: CL:0000094 ! granulocyte intersection_of: RO:0002104 PR:000001254 ! has plasma membrane part C-C chemokine receptor type 1 intersection_of: RO:0002104 PR:000001255 ! has plasma membrane part C-C chemokine receptor type 3 intersection_of: RO:0002104 PR:000001307 ! has plasma membrane part CD44 molecule intersection_of: RO:0002104 PR:000001343 ! has plasma membrane part CD69 molecule intersection_of: RO:0002104 PR:000005178 ! has plasma membrane part CD9 molecule relationship: RO:0002104 PR:000001254 ! has plasma membrane part C-C chemokine receptor type 1 relationship: RO:0002104 PR:000001255 ! has plasma membrane part C-C chemokine receptor type 3 relationship: RO:0002104 PR:000001307 ! has plasma membrane part CD44 molecule relationship: RO:0002104 PR:000001343 ! has plasma membrane part CD69 molecule relationship: RO:0002104 PR:000005178 ! has plasma membrane part CD9 molecule property_value: RO:0002175 NCBITaxon:9606 property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0000771" xsd:string {name="eosinophil on CELLxGENE CellGuide"} property_value: terms:description "Eosinophils are a type of granulocyte derived from myeloid progenitors in the bone marrow; they are a part of the body's immune system. Named for their affinity to eosin, a red acidic dye used in staining procedures, eosinophils contribute to the immune system's response by migrating to inflammation sites, particularly those produced by allergic reactions and infections due to multicellular parasites. They comprise ~1-5% of the white blood cells in circulation.\nEosinophils play crucial roles in mediating inflammatory responses. They carry granules containing a variety of enzymes and proteins, including major basic protein (MBP), eosinophil peroxidase (EPO), eosinophil cationic protein (ECP), and eosinophil-derived neurotoxin (EDN). These enzymes and proteins are effective in killing bacteria, parasites, and some cancer cells. When exposed to an antigen, eosinophils degranulate and release these mediators to the site of infection, resulting in the destruction of invading microorganisms. Specifically, in parasitic infections, eosinophils attach themselves to the parasites and release these cytotoxic granules, causing a lethal rupture in the parasite's surface. Eosinphils may also release cytokines to attract other immune cells to sites of infection and to skew the response towards type 2 immunity.\nEosinophils are also involved in conditions such as asthma and allergic reactions. They secrete chemical mediators such as leukotrienes and prostaglandins that trigger contraction of smooth muscles, causing symptoms such as bronchoconstriction observed in asthma. However, these multifunctional cells, while useful in defending the body, may also inadvertently cause tissue damage if excessively activated. Increased numbers of eosinophils, a condition known as eosinophilia, can indicate a variety of diseases including allergies, skin disorders, parasitic and fungal infections, autoimmune diseases, certain types of cancer, and asthma.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1016/j.mayocp.2021.04.025", xref="DOI:10.1038/nri3341", xref="DOI:10.1128/microbiolspec.mchd-0020-2015", xref="DOI:10.1146/annurev-pathmechdis-012419-032756", xref="DOI:10.1182/blood-2012-06-330845"} [Term] id: CL:0000772 name: immature eosinophil def: "Any of the immature forms of an eosinophil, in which eosinophilic specific granules are present but other phenotypic features of the mature form may be lacking." [GOC:add, ISBN:0721601464] subset: human_subset subset: mouse_subset synonym: "immature eosinocyte" EXACT [] synonym: "immature eosinophilic leucocyte" EXACT [] synonym: "immature eosinophilic leukocyte" EXACT [] is_a: CL:0000771 {is_inferred="true"} ! eosinophil intersection_of: CL:0000771 ! eosinophil intersection_of: BFO:0000051 CL:0017509 ! has part alobate nucleus relationship: BFO:0000051 CL:0017509 ! has part alobate nucleus relationship: RO:0002202 CL:0000833 ! develops from eosinophilic promyelocyte [Term] id: CL:0000773 name: eosinophilic metamyelocyte def: "A eosinophil precursor in the granulocytic series, being a cell intermediate in development between a eosinophilic myelocyte and a band form eosinophil. The nucleus becomes indented where the indentation is smaller than half the distance to the farthest nuclear margin; chromatin becomes coarse and clumped; specific granules predominate while primary granules are rare. Markers are integrin alpha-M-positive, fucosyltransferase FUT4-positive, low affinity immunoglobulin gamma Fc region receptor III-positive, CD33-positive, CD24-positive and aminopeptidase N-negative." [GOC:add, GOC:tfm, ISBN:0721601464, PMID:19622087] subset: human_subset subset: mouse_subset is_a: CL:0000772 {is_inferred="true"} ! immature eosinophil is_a: CL:0002192 ! metamyelocyte intersection_of: CL:0000772 ! immature eosinophil intersection_of: BFO:0000051 CL:0017502 ! has part acidophilic cytoplasm intersection_of: BFO:0000051 CL:0017507 ! has part reniform nucleus intersection_of: BFO:0000051 GO:0000792 ! has part heterochromatin intersection_of: BFO:0000051 GO:0042582 ! has part azurophil granule intersection_of: BFO:0000051 GO:0070820 ! has part tertiary granule intersection_of: RO:0002104 PR:000001012 ! has plasma membrane part integrin alpha-M intersection_of: RO:0002104 PR:000001456 ! has plasma membrane part alpha-(1,3)-fucosyltransferase 4 intersection_of: RO:0002104 PR:000001483 ! has plasma membrane part low affinity immunoglobulin gamma Fc region receptor III intersection_of: RO:0002104 PR:000001892 ! has plasma membrane part CD33 molecule intersection_of: RO:0002104 PR:000001932 ! has plasma membrane part signal transducer CD24 intersection_of: RO:0002104 PR:000002031 ! has plasma membrane part aminopeptidase N relationship: BFO:0000051 CL:0017502 ! has part acidophilic cytoplasm relationship: BFO:0000051 CL:0017507 ! has part reniform nucleus relationship: BFO:0000051 GO:0000792 ! has part heterochromatin relationship: BFO:0000051 GO:0042582 ! has part azurophil granule relationship: BFO:0000051 GO:0070820 ! has part tertiary granule relationship: RO:0002104 PR:000001456 ! has plasma membrane part alpha-(1,3)-fucosyltransferase 4 relationship: RO:0002104 PR:000001483 ! has plasma membrane part low affinity immunoglobulin gamma Fc region receptor III relationship: RO:0002104 PR:000001892 ! has plasma membrane part CD33 molecule relationship: RO:0002104 PR:000001932 ! has plasma membrane part signal transducer CD24 relationship: RO:0002104 PR:000002031 ! has plasma membrane part aminopeptidase N relationship: RO:0002202 CL:0000612 ! develops from eosinophilic myelocyte [Term] id: CL:0000774 name: band form eosinophil def: "A late eosinophilic metamyelocyte in which the nucleus is in the form of a curved or coiled band, not having acquired the typical multilobar shape of the mature eosinophil." [GOC:add, GOC:tfm, http://www.cap.org, ISBN:0721601464, PMID:19622087] subset: human_subset subset: mouse_subset is_a: CL:0000772 {is_inferred="true"} ! immature eosinophil intersection_of: CL:0000772 ! immature eosinophil intersection_of: BFO:0000051 CL:0017506 ! has part banded nucleus relationship: BFO:0000051 CL:0017506 ! has part banded nucleus relationship: RO:0002202 CL:0000773 ! develops from eosinophilic metamyelocyte [Term] id: CL:0000775 name: neutrophil def: "Any of the immature or mature forms of a granular leukocyte that in its mature form has a nucleus with three to five lobes connected by slender threads of chromatin, and cytoplasm containing fine inconspicuous granules and stainable by neutral dyes." [GOC:add, GOC:amm, GOC:tfm, ISBN:0721601464] subset: blood_and_immune_upper_slim subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "neutrocyte" EXACT [] synonym: "neutrophil leucocyte" EXACT [] synonym: "neutrophil leukocyte" EXACT [] synonym: "neutrophilic leucocyte" EXACT [] synonym: "neutrophilic leukocyte" EXACT [] synonym: "PMN" BROAD [] synonym: "poly" BROAD [] synonym: "polymorphonuclear leucocyte" BROAD [] synonym: "polymorphonuclear leukocyte" BROAD [] synonym: "polymorphonuclear neutrophil" BROAD [] synonym: "polynuclear neutrophilic leucocyte" BROAD [] synonym: "polynuclear neutrophilic leukocyte" BROAD [] xref: BTO:0000130 xref: CALOHA:TS-0688 xref: FMA:62860 xref: MESH:D009504 xref: ZFA:0009327 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000094 {is_inferred="true"} ! granulocyte intersection_of: CL:0000094 ! granulocyte intersection_of: RO:0002104 PR:000001479 ! has plasma membrane part low affinity immunoglobulin gamma Fc region receptor II intersection_of: RO:0002104 PR:000001879 ! has plasma membrane part leukosialin relationship: RO:0002104 PR:000001479 ! has plasma membrane part low affinity immunoglobulin gamma Fc region receptor II relationship: RO:0002104 PR:000001879 ! has plasma membrane part leukosialin property_value: RO:0002175 NCBITaxon:9606 property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0000775" xsd:string {name="neutrophil on CELLxGENE CellGuide"} property_value: terms:description "Neutrophils are an essential component of the human immune system and belong to the category of white blood cells known as granulocytes. They constitute approximately 50-70% of all white blood cells, making them the most abundant type of immune cells in mammals. Neutrophils develop in the bone marrow from hematopoietic stem cells before being released into the bloodstream where they circulate before migration into tissues, thereby exhibiting a multi-step process that includes margination, rolling, adhesion, and transmigration.\nPhenotypically and functionally, neutrophils represent a heterogeneous cell population. They are the immune system’s immediate responders and are the first cells to migrate towards the site of an infection. They play a critical role in defending the body from potential pathogenic bacteria and fungi. Their primary mechanism of action involves phagocytosis, where they engulf and destroy these microbes. Neutrophils are characterized by the presence of large quantities of granules containing antimicrobial proteins and enzymes, including defensins and myeloperoxidase, which are released once the cell has recognized and attached to the microbes. The enzymes and other antimicrobial agents can also be released into the surrounding environment, a process known as degranulation.\nNeutrophils also possess the unique biological ability to eliminate pathogens through a process called neutrophil extracellular trap (NET) formation, or NETosis. In this process, neutrophils release a mixture of DNA, histones, and granule proteins that form a web-like structure which traps and kills microbes. Notably, this process usually leads to the death of the neutrophil itself, referred to as cell suicide or programmed cell death. \nNeutrophils play a crucial role in the immune system by rapidly responding to infections and inflammation, excessive or dysregulated neutrophil activity can contribute to tissue damage and chronic inflammation, exacerbating various diseases such as rheumatoid arthritis, and neutrophils may contribute to tumor growth and progression.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1007/s10753-016-0458-4", xref="DOI:10.1038/s41577-019-0141-8", xref="DOI:10.1038/s41577-021-00571-6", xref="DOI:10.1111/febs.15803", xref="DOI:10.3389/fphys.2018.00113"} [Term] id: CL:0000776 name: immature neutrophil def: "Any of the immature forms of a neutrophil in which neutrophilic specific granules are present but other phenotypic features of the mature form may be lacking." [GOC:add, ISBN:0721601464] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "immatuer neutrophilic leukocyte" EXACT [] synonym: "immature neutrocyte" EXACT [] synonym: "immature neutrophil leucocyte" EXACT [] synonym: "immature neutrophil leukocyte" EXACT [] synonym: "immature neutrophilic leucocyte" EXACT [] xref: ZFA:0009328 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000775 {is_inferred="true"} ! neutrophil intersection_of: CL:0000775 ! neutrophil intersection_of: BFO:0000051 CL:0017509 ! has part alobate nucleus relationship: BFO:0000051 CL:0017509 ! has part alobate nucleus relationship: RO:0002202 CL:0000564 ! develops from neutrophilic promyelocyte property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0000776" xsd:string {name="immature neutrophil on CELLxGENE CellGuide"} property_value: terms:description "An immature neutrophil, also known as a band neutrophil or band cell, is an intermediary stage in neutrophilic granulocyte development. Immature neutrophils are formed in the bone marrow then released into the bloodstream where they eventually mature into functional, mature segmented neutrophils. They are characterized by an unsegmented, curved nucleus, a distinguishing factor that differentiates them from mature neutrophils, which possess a multi-lobed nucleus.\nImmature neutrophils can be found in circulation, but their numbers may increase drastically during infection. These cells are released from the bone marrow as a result of emergency granulopoiesis. The role of these cells in infection and acute inflammation remains controversial, and it has been suggested that these cells could possess immunosuppressive or proinflammatory activity. \nAn increase of immature neutrophils in the bloodstream, a condition referred to as bandemia or a left shift, can be an important clinical indicator. While low-level presence is typical, an abnormally high count can signal severe or systemic bacterial infection, inflammation, or less commonly, diseases that affect bone marrow function such as leukemia. However, not all bacterial infections will result in a left shift.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1016/j.cca.2016.03.017", xref="DOI:10.1016/j.it.2019.04.012", xref="DOI:10.1016/j.it.2019.04.013", xref="DOI:10.3389/fimmu.2020.01259/full"} [Term] id: CL:0000777 name: mesangial phagocyte def: "A tissue-resident macrophage of the renal glomerular mesangium involved in the disposal and degradation of filtration residues, presentation of antigen to T cells and in tissue remodeling." [GOC:add, GOC:tfm, ISBN:0702022918, ISBN:3540536663, PMID:1600140, PMID:16146841] subset: human_subset subset: mouse_subset synonym: "mesangial cell" BROAD [] is_a: CL:0000864 {is_inferred="true"} ! tissue-resident macrophage intersection_of: CL:0000864 ! tissue-resident macrophage intersection_of: RO:0001025 UBERON:0002320 ! located in glomerular mesangium intersection_of: RO:0002215 GO:0019882 ! capable of antigen processing and presentation intersection_of: RO:0002215 GO:0048771 ! capable of tissue remodeling relationship: RO:0001025 UBERON:0002320 ! located in glomerular mesangium relationship: RO:0002215 GO:0048771 ! capable of tissue remodeling [Term] id: CL:0000778 name: mononuclear osteoclast def: "A specialized mononuclear osteoclast associated with the absorption and removal of bone, precursor of multinuclear osteoclasts." [GOC:add, GOC:tfm, PMID:12713016, PMID:15055519, PMID:17380158, PMID:9415452] comment: Morphology: mononuclear, highly vesicular. subset: human_subset subset: mouse_subset xref: ZFA:0009329 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000092 {is_inferred="true"} ! osteoclast is_a: CL:0000113 ! mononuclear phagocyte intersection_of: CL:0000092 ! osteoclast intersection_of: RO:0000053 PATO:0001407 ! has characteristic mononucleate [Term] id: CL:0000779 name: multinuclear osteoclast def: "A specialized multinuclear osteoclast, forming a syncytium through the fusion of mononuclear precursor cells, associated with the absorption and removal of bone." [GOC:add, PMID:12713016, PMID:29379067, PMID:38903088, PMID:9415452] comment: Morphology: multinucleated, highly vesicular. subset: human_subset subset: mouse_subset synonym: "multinucleated osteoclast" EXACT [] is_a: CL:0000092 {is_inferred="true"} ! osteoclast is_a: CL:0000783 ! multinucleated phagocyte is_a: CL:4052002 ! syncytial cell intersection_of: CL:0000092 ! osteoclast intersection_of: RO:0000053 PATO:0001908 ! has characteristic multinucleate relationship: RO:0002202 CL:0000778 ! develops from mononuclear osteoclast [Term] id: CL:0000780 name: multinuclear odontoclast def: "A specialized multinuclear osteoclast associated with the absorption and removal of cementum." [GOC:add, PMID:9415452] comment: Morphology: multinucleated, highly vesicular; location: roots of deciduous (milk) teeth. subset: human_subset subset: mouse_subset synonym: "multinucleated odontoclast" EXACT [] is_a: CL:0000588 {is_inferred="true"} ! odontoclast is_a: CL:0000779 ! multinuclear osteoclast intersection_of: CL:0000588 ! odontoclast intersection_of: RO:0000053 PATO:0001908 ! has characteristic multinucleate relationship: RO:0002202 CL:0000781 ! develops from mononuclear odontoclast [Term] id: CL:0000781 name: mononuclear odontoclast def: "A specialized mononuclear osteoclast associated with the absorption and removal of cementum." [GOC:add, PMID:9415452] comment: Morphology: Mononuclear, highly vesicular; location: roots of deciduous (milk) teeth. subset: human_subset subset: mouse_subset xref: ZFA:0009330 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000588 {is_inferred="true"} ! odontoclast is_a: CL:0000778 {is_inferred="true"} ! mononuclear osteoclast intersection_of: CL:0000588 ! odontoclast intersection_of: RO:0000053 PATO:0001407 ! has characteristic mononucleate [Term] id: CL:0000782 name: myeloid dendritic cell def: "A dendritic cell of the myeloid lineage." [GOC:add, PMID:10449155, PMID:17332250, PMID:9521319] comment: These cells are CD1a-negative, CD1b-positive, CD11a-positive, CD11c-positive, CD13-positive, CD14-negative, CD20-negative, CD21-negative, CD33-positive, CD40-negative, CD50-positive, CD54-positive, CD58-positive, CD68-negative, CD80-negative, CD83-negative, CD85j-positive, CD86-positive, CD89-negative, CD95-positive, CD120a-negative, CD120b-positive, CD123-negative, CD178-negative, CD206-negative, CD207-negative, CD209-negative, and TNF-alpha-negative. Upon TLR stimulation, they are capable of producing high levels of TNF-alpha, IL-6, CXCL8 (IL-8). subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "CD11c+CD123- DC" EXACT [] synonym: "interdigitating cell" BROAD [] synonym: "mDC" EXACT [] synonym: "veiled cell" BROAD [] xref: BTO:0004721 is_a: CL:0000766 ! myeloid leukocyte is_a: CL:0000990 {is_inferred="true"} ! conventional dendritic cell intersection_of: CL:0000990 ! conventional dendritic cell intersection_of: CL:4030046 PR:000001865 ! lacks_plasma_membrane_part interleukin-3 receptor class 2 alpha chain intersection_of: RO:0002202 CL:0000763 ! develops from myeloid cell relationship: CL:4030046 PR:000001865 ! lacks_plasma_membrane_part interleukin-3 receptor class 2 alpha chain relationship: RO:0002202 CL:0000763 ! develops from myeloid cell property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0000782" xsd:string {name="myeloid dendritic cell on CELLxGENE CellGuide"} property_value: terms:description "Myeloid dendritic cells are a subset of dendritic cells derived from the common myeloid progenitor cell. \"Conventional\" and \"myeloid\" DCs are often used interchangeably. In contrast, dendritic cells may also arise from the common lymphoid progenitor. Monocyte-derived dendritic cells may also be induced by inflammatory states.\nDendritic cells function as antigen-presenting cells and are able to activate naïve T cells to induce the adaptive immune response. Dendritic cells capture, process, and present antigens derived from pathogens to mount a specific immune response against the invading antigen. Dendritic cells also produce a range of cytokines that help in modulating and recruiting other immune cells during an immune response. \nDendritic cells can contribute to immune tolerance by deleting self-reactive T cells or by inducing regulatory T-cells, thereby preventing autoimmunity. Dendritic cells thus are important in orchestrating the adaptive immune response and are pivotal in combating infections and maintaining tolerance to self.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1002/jlb.66.2.205", xref="DOI:10.1016/j.imbio.2014.12.010", xref="DOI:10.1016/j.immuni.2007.06.006", xref="DOI:10.1111/imm.12888", xref="DOI:10.3389/fimmu.2018.03176"} [Term] id: CL:0000783 name: multinucleated phagocyte def: "A phagocyte formed by the fusion of mononuclear phagocytes." [GOC:add, GOC:tfm] subset: human_subset subset: mouse_subset is_a: CL:0000228 ! multinucleate cell is_a: CL:0000518 {is_inferred="true"} ! phagocyte (sensu Vertebrata) intersection_of: CL:0000518 ! phagocyte (sensu Vertebrata) intersection_of: RO:0000053 PATO:0001908 ! has characteristic multinucleate [Term] id: CL:0000784 name: plasmacytoid dendritic cell def: "A dendritic cell type of distinct morphology, localization, and surface marker expression (CD123-positive) from other dendritic cell types and associated with early stage immune responses, particularly the release of physiologically abundant amounts of type I interferons in response to infection." [GOC:add, GOC:dsd, PMCID:PMC2118448, PMCID:PMC538703, PMID:15549123, PMID:17332250, PMID:17850486, PMID:20304825] subset: blood_and_immune_upper_slim subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "DC2" EXACT [] synonym: "interferon-producing cell" EXACT [] synonym: "IPC" EXACT [] synonym: "lymphoid dendritic cell" EXACT [] synonym: "pDC" EXACT [] synonym: "plasmacytoid monocyte" EXACT [] synonym: "plasmacytoid T cell" EXACT [] synonym: "T-associated plasma cell" EXACT [] synonym: "type 2 DC" EXACT [] xref: BTO:0004625 is_a: CL:0000451 {is_inferred="true"} ! dendritic cell intersection_of: CL:0000451 ! dendritic cell intersection_of: RO:0002215 GO:0032606 ! capable of type I interferon production relationship: RO:0002215 GO:0032606 ! capable of type I interferon production property_value: RO:0002175 NCBITaxon:9606 property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0000784" xsd:string {name="plasmacytoid dendritic cell on CELLxGENE CellGuide"} property_value: terms:description "Plasmacytoid dendritic cells (pDCs), initially known as interferon-producing cells, are a unique subpopulation of dendritic cells. Unlike conventional dendritic cells (cDCs), plasmacytoid dendritic cells are characterized by their distinctive plasma cell-like morphology. These cells play vital roles in the innate and adaptive immune response, particularly in the antiviral response. Highly prevalent in the blood and lymphoid organs, pDCs are rare in non-lymphoid tissues, with the exception of inflamed tissues and tumors where they are often recruited.\nA key role of plasmacytoid dendritic cells is their rapid and robust production of type 1 interferons in response to viral infections. This is crucial for antiviral defense as interferon signals to other immune cells to increase their antiviral defenses. pDCs achieve this by detecting viral nucleic acids in the cytosol through Toll-like receptors (TLRs), specifically TLR7 and TLR9. Upon recognition, these cells quickly produce substantial amounts of interferons, which plays a significant role in the containment of viral replication and the development of acquired antiviral immunity.\nThe potential of plasmacytoid dendritic cells for antigen presentations to naive T cells is relatively low under steady-state conditions. Upon activation by certain stimuli, such as viruses or CpG oligodeoxynucleotides, they have the ability to differentiate into efficient antigen-presenting cells. This transition to activated cells involves an upregulation of major histocompatibility complex (MHC) class II molecules and co-stimulatory molecules, thus allowing them to effectively present antigenic peptides to naive T cells. This crucial function in linking innate and adaptive immunity underlines the importance of pDCs to the overall immune response.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1016/bs.ircmb.2019.07.004", xref="DOI:10.1016/j.immuni.2007.06.006", xref="DOI:10.1016/j.immuni.2018.12.027", xref="DOI:10.1038/nri3865"} [Term] id: CL:0000785 name: mature B cell def: "A B cell that is mature, having left the bone marrow. Initially, these cells are IgM-positive and IgD-positive, and they can be activated by antigen." [GOC:add, GOC:dsd, ISBN:0781735149] comment: Mature B cells are also reportedly CD10-negative, CD19-positive, CD22-positive, CD34-negative, CD48-positive, CD79a-positive, CD84-positive, CD127-negative, CD352-positive, RAG-negative, TdT-negative, Vpre-B-negative, and pre-BCR-negative. Transcription factors expressed: Pax5-positive. subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "mature B lymphocyte" EXACT [] synonym: "mature B-cell" EXACT [] synonym: "mature B-lymphocyte" EXACT [] xref: ZFA:0009331 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000145 ! professional antigen presenting cell is_a: CL:0001201 {is_inferred="true"} ! B cell, CD19-positive intersection_of: CL:0001201 ! B cell, CD19-positive intersection_of: RO:0002215 GO:0002504 ! capable of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II intersection_of: RO:0002215 GO:0042113 ! capable of B cell activation intersection_of: RO:0002353 GO:0002335 ! output of mature B cell differentiation disjoint_from: CL:0000816 ! immature B cell disjoint_from: CL:0000817 ! precursor B cell disjoint_from: CL:0000818 ! transitional stage B cell relationship: RO:0002202 CL:0000818 ! develops from transitional stage B cell relationship: RO:0002215 GO:0042113 ! capable of B cell activation relationship: RO:0002353 GO:0002335 ! output of mature B cell differentiation [Term] id: CL:0000786 name: plasma cell def: "A terminally differentiated, post-mitotic, antibody secreting cell of the B cell lineage with the phenotype CD138-positive, surface immunonoglobulin-negative, and MHC Class II-negative. Plasma cells are oval or round with extensive rough endoplasmic reticulum, a well-developed Golgi apparatus, and a round nucleus having a characteristic cartwheel heterochromatin pattern and are devoted to producing large amounts of immunoglobulin." [GO_REF:0000031, GOC:add, GOC:dsd, http://en.wikipedia.org/wiki/Plasma_cell, ISBN:0721601464, ISBN:0781735149, PMID:19447676, PMID:20081059, PMID:20839338, PMID:20951740] comment: Plasma cells develop in the spleen and migrate to the bone marrow. Plasma cells are also reportedly CD5-negative, CD10-negative, CD19-positive, CD20-negative, CD21-negative, CD22-negative, CD23-negative, CD24-negative, CD25-negative, CD27-positive, CD34-negative, CD38-positive, CD40-positive, CD43-positive, CD45-positive, CD48-positive, CD53-low, CD80-negative, CD81-positive, CD86-positive, CD95-positive, CD196-negative, CD229-positive, CD270-positive, CD352-positive, CD361-positive, and IgD-negative. Transcription factors: BLIMP1-positive, IRF4-positive, PAX5-negative, SpiB-negative, Ets1-negative, and XBP1-positive. subset: blood_and_immune_upper_slim subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "effector B cell" RELATED [] synonym: "effector B-cell" RELATED [] synonym: "plasma B cell" EXACT [] synonym: "plasma B-cell" EXACT [] synonym: "plasmacyte" EXACT [] synonym: "plasmocyte" EXACT [] xref: BTO:0000392 xref: FMA:70574 xref: MESH:D010950 xref: ZFA:0009332 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000946 {is_inferred="true"} ! antibody secreting cell intersection_of: CL:0000946 ! antibody secreting cell intersection_of: BFO:0000051 CL:0017508 ! has part cartwheel heterochromatin intersection_of: BFO:0000051 GO:0005794 ! has part Golgi apparatus intersection_of: CL:4030046 GO:0019814 ! lacks_plasma_membrane_part immunoglobulin complex intersection_of: CL:4030046 GO:0042613 ! lacks_plasma_membrane_part MHC class II protein complex intersection_of: CL:4030046 PR:000001289 ! lacks_plasma_membrane_part membrane-spanning 4-domains subfamily A member 1 intersection_of: RO:0002104 PR:000001935 ! has plasma membrane part syndecan-1 relationship: BFO:0000051 CL:0017508 ! has part cartwheel heterochromatin relationship: BFO:0000051 GO:0005794 ! has part Golgi apparatus relationship: CL:4030046 GO:0019814 ! lacks_plasma_membrane_part immunoglobulin complex relationship: CL:4030046 GO:0042613 ! lacks_plasma_membrane_part MHC class II protein complex relationship: CL:4030046 PR:000001289 ! lacks_plasma_membrane_part membrane-spanning 4-domains subfamily A member 1 relationship: RO:0002104 PR:000001935 ! has plasma membrane part syndecan-1 relationship: RO:0002202 CL:0000980 ! develops from plasmablast property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0000787 name: memory B cell def: "A memory B cell is a mature B cell that is long-lived, readily activated upon re-encounter of its antigenic determinant, and has been selected for expression of higher affinity immunoglobulin. This cell type has the phenotype CD19-positive, CD20-positive, MHC Class II-positive, and CD138-negative." [GO_REF:0000031, GOC:add, GOC:dsd, GOC:rhs, http://en.wikipedia.org/wiki/Memory_B_cell, ISBN:0781735149, PMID:20081059, PMID:20839338] comment: Memory B-cells are also reportedly CD5-negative, CD10-negative, CD21-positive, CD22-positive, CD23-negative, CD24-positive, CD25-positive, CD27-positive, CD34-negative, CD38-negative, CD40-positive, CD43-negative, CD44-positive, CD45-positive, CD53-positive, CD80-negative, CD81-negative, CD86-positive, and CD196/CCR6-positive. subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "memory B lymphocyte" EXACT [] synonym: "memory B-cell" EXACT [] synonym: "memory B-lymphocyte" EXACT [] xref: ZFA:0009333 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000785 {is_inferred="true"} ! mature B cell intersection_of: CL:0000785 ! mature B cell intersection_of: CL:4030046 PR:000001935 ! lacks_plasma_membrane_part syndecan-1 intersection_of: RO:0002104 GO:0042613 ! has plasma membrane part MHC class II protein complex intersection_of: RO:0002104 PR:000001289 ! has plasma membrane part membrane-spanning 4-domains subfamily A member 1 intersection_of: RO:0002353 GO:0002344 ! output of B cell affinity maturation relationship: CL:4030046 PR:000001935 ! lacks_plasma_membrane_part syndecan-1 relationship: RO:0002104 GO:0042613 ! has plasma membrane part MHC class II protein complex relationship: RO:0002104 PR:000001289 ! has plasma membrane part membrane-spanning 4-domains subfamily A member 1 relationship: RO:0002353 GO:0002344 ! output of B cell affinity maturation property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0000788 name: naive B cell def: "A naive B cell is a mature B cell that has the phenotype surface IgD-positive, surface IgM-positive, CD20-positive, CD27-negative and that has not yet been activated by antigen in the periphery." [GO_REF:0000031, GOC:add, GOC:dsd, GOC:rhs, ISBN:0781765196, PMID:19447676, PMID:20081059, PMID:20839338, PMID:20933013, PMID:22343568] comment: This cell type is compatible with the HIPC Lyoplate markers for 'naive B cell'. Per DSD: Naive B cells are also reportedly CD10-negative, CD19-positive, CD20-positive, CD21-positive, CD22-positive, CD25-negative, CD27-negative, CD34-negative, CD40-positive, CD43-negative, CD45-positive, CD48-positive, CD53-positive, CD80-negative, CD81-positive, CD84-positive, CD86-negative, CD95-negative, CD138-negative, CD150-positive, CD184/CXCR4-positive, CD185/CXCR5-positive, CD196/CCR6-positive, CD200-positive, CD229-positive, CD243-positive, CD289-positive, CD290-positive, CD352-positive, MHCII/HLA-DR-positive, cadherin 9-positive, and sIgH-positive, Transcription factors: Pax5-positive, ETS1-positive, FOXO1A-positive, KLF4-positive, KLF9-positive, MiTF-positive, OBF1-positive, PLZF-positive, and SpiB-positive. subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "naive B lymphocyte" EXACT [] synonym: "naive B-cell" EXACT [] synonym: "naive B-lymphocyte" EXACT [] xref: ZFA:0009334 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000785 {is_inferred="true"} ! mature B cell intersection_of: CL:0000785 ! mature B cell intersection_of: CL:4030044 GO:0002344 ! has_not_completed B cell affinity maturation intersection_of: CL:4030046 PR:000001963 ! lacks_plasma_membrane_part CD27 molecule intersection_of: RO:0002104 GO:0071738 ! has plasma membrane part IgD immunoglobulin complex intersection_of: RO:0002104 GO:0071753 ! has plasma membrane part IgM immunoglobulin complex intersection_of: RO:0002104 PR:000001289 ! has plasma membrane part membrane-spanning 4-domains subfamily A member 1 relationship: CL:4030044 GO:0002344 ! has_not_completed B cell affinity maturation relationship: CL:4030046 PR:000001963 ! lacks_plasma_membrane_part CD27 molecule relationship: RO:0002104 GO:0071738 ! has plasma membrane part IgD immunoglobulin complex relationship: RO:0002104 GO:0071753 ! has plasma membrane part IgM immunoglobulin complex relationship: RO:0002104 PR:000001289 ! has plasma membrane part membrane-spanning 4-domains subfamily A member 1 property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0000789 name: alpha-beta T cell def: "A T cell that expresses an alpha-beta T cell receptor complex." [GOC:add, GOC:tfm, ISBN:0781735149] subset: blood_and_immune_upper_slim subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "alpha-beta T lymphocyte" EXACT [] synonym: "alpha-beta T-cell" EXACT [] synonym: "alpha-beta T-lymphocyte" EXACT [] xref: ZFA:0009335 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000084 {is_inferred="true"} ! T cell intersection_of: CL:0000084 ! T cell intersection_of: RO:0002104 GO:0042105 ! has plasma membrane part alpha-beta T cell receptor complex disjoint_from: CL:0000798 ! gamma-delta T cell relationship: RO:0002104 GO:0042105 ! has plasma membrane part alpha-beta T cell receptor complex [Term] id: CL:0000790 name: immature alpha-beta T cell def: "An alpha-beta T cell that has an immature phenotype and has not completed T cell selection." [GOC:add, GOC:tfm, ISBN:0781735149] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "immature alpha-beta T lymphocyte" EXACT [] synonym: "immature alpha-beta T-cell" EXACT [] synonym: "immature alpha-beta T-lymphocyte" EXACT [] is_a: CL:0000789 {is_inferred="true"} ! alpha-beta T cell is_a: CL:0002420 ! immature T cell intersection_of: CL:0000789 ! alpha-beta T cell intersection_of: CL:4030044 GO:0045058 ! has_not_completed T cell selection property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0000790" xsd:string {name="immature alpha-beta T cell on CELLxGENE CellGuide"} property_value: terms:description "Immature alpha-beta T cells represent a subpopulation of T cells in the thymus that are at a development stage in which they are yet to attain full functional status. The term 'alpha-beta' refers to the two distinct types of chains, alpha (α) and beta (β), which form the T cell receptor (TCR) located on the cell's surface. This T cell receptor enables the cell to identify and bind to specific antigens in order to initiate an immune response.\nImmature alpha-beta T cells arise from lymphoid progenitor cells in the bone marrow and migrate to the thymus, where the maturation of T cells takes place. In the thymus, immature cells (thymocytes) undergo a series of division and differentiation events characterized by the rearrangement of their TCR genes. Upon successful recombination, the cells express a functional alpha-beta TCR on their surface and can then be subjected to a process of selection based on the specificity of the newly expressed receptors. These stages of development are critical to ensuring that only cells with a suitable TCR repertoire survive, ready to be deployed within the immune system. \nMultiple subsets of immature alpha-beta T cells can be distinguished, depending on the developmental and differentiation stage, including CD4+CD8+ double positive thymocytes, CD4+ or CD8+ single positive thymocytes and immature NK T cells. \nImmature alpha-beta T cells are critically important to immune function. They constitute the foundation for the adaptive immune system - a fundamental component in combating pathological agents. Once fully matured, these cells can differentiate further into effector T cell types (like helper, cytotoxic, and regulatory T cells), each having unique functional roles in an immune response. The proper development of immature alpha-beta T cells is fundamental to the overall health and efficacy of the immune system.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1016/j.immuni.2018.01.007", xref="DOI:10.1016/j.immuni.2020.03.019", xref="DOI:10.1038/s41392-023-01471-y", xref="DOI:10.3389/fimmu.2022.884569", xref="https://www.sciencedirect.com/topics/immunology-and-microbiology/alpha-beta-t-cell"} [Term] id: CL:0000791 name: mature alpha-beta T cell def: "A alpha-beta T cell that has a mature phenotype." [GOC:add, GOC:tfm, ISBN:0781735149] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "mature alpha-beta T lymphocyte" EXACT [] synonym: "mature alpha-beta T-cell" EXACT [] synonym: "mature alpha-beta T-lymphocyte" EXACT [] is_a: CL:0000789 {is_inferred="true"} ! alpha-beta T cell is_a: CL:0002419 ! mature T cell intersection_of: CL:0000789 ! alpha-beta T cell intersection_of: RO:0002353 GO:0045058 ! output of T cell selection relationship: RO:0002202 CL:0000790 ! develops from immature alpha-beta T cell property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0000791" xsd:string {name="mature alpha-beta T cell on CELLxGENE CellGuide"} property_value: terms:description "Mature alpha-beta T cells, also known as αβ T cells, are critical components of the adaptive immune system, responsible for a mediated immune response to pathogens and infected body cells. They derive their name from the alpha and beta chains that make up their characteristic T-cell receptor (TCR), a protein complex that binds to antigens. These cells undergo a maturation process in the thymus, where they learn to recognize self-antigens, thus achieving self-tolerance.\nMaturation of alpha-beta T cells takes place in the thymus and is tightly controlled by various transcriptional and epigenetic regulators. They develop through several stages from progenitors to mature T cells, from CD4-CD8- double negative cells to CD4+CD8+ double positive cells, until they eventually become CD4+ or CD8+ single positive cells.\nOnce matured, alpha-beta T cells primarily serve as regulators and effectors in an immune response. They are adept at recognizing fragments of antigens, often viruses or bacteria, presented on the surface of other cells via major histocompatibility complex (MHC) molecules. Once they encounter and recognize an antigen, they become activated, proliferate and differentiate into distinct subsets of effector T cells, such as cytotoxic T cells, helper T cells, and Natural Killer (NK) cells, each with a specific role in immune response.\nCytotoxic T cells, the effector cells for cell-mediated immunity, are adept at killing cells that have been infected, particularly with viruses. They do this by binding to infected cells and releasing cytotoxic substances which induce apoptosis, or cell death, thus eliminating the infected cells. The main function of NK cells is to kill virally infected cells, and to detect early signs of cancer. Helper T cells do not kill infected cells directly but play a key role in modulating or orchestrating the immune response by releasing cytokines that recruit and regulate other immunity cells such as B cells and macrophages. Therefore, the versatile roles of mature alpha-beta T cells are vital for maintaining the body's successful adaptive immune defenses.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1016/j.immuni.2018.01.007", xref="DOI:10.1038/s41392-023-01471-y", xref="DOI:10.3389/fimmu.2022.884569", xref="https://www.sciencedirect.com/topics/immunology-and-microbiology/alpha-beta-t-cell"} [Term] id: CL:0000792 name: CD4-positive, CD25-positive, alpha-beta regulatory T cell def: "A CD4-positive, CD25-positive, alpha-beta T cell that regulates overall immune responses as well as the responses of other T cell subsets through direct cell-cell contact and cytokine release." [GOC:add, GOC:tfm, ISBN:0781735149, PMID:19464985, PMID:22343568] comment: This cell type is compatible with the HIPC Lyoplate markers for 'Treg'. The inclusion of CD127lo in the logical definition is compatible with both human and mouse T cells of this subtype. subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "CD4-positive, CD25-positive, alpha-beta regulatory T lymphocyte" EXACT [] synonym: "CD4-positive, CD25-positive, alpha-beta regulatory T-cell" EXACT [] synonym: "CD4-positive, CD25-positive, alpha-beta regulatory T-lymphocyte" EXACT [] synonym: "suppressor T cell" BROAD [] synonym: "suppressor T lymphocyte" BROAD [] synonym: "suppressor T-cell" BROAD [] synonym: "suppressor T-lymphocyte" BROAD [] synonym: "Treg" BROAD [PMID:22343568] is_a: CL:0000624 {is_inferred="true"} ! CD4-positive, alpha-beta T cell is_a: CL:0000815 ! regulatory T cell intersection_of: CL:0000624 ! CD4-positive, alpha-beta T cell intersection_of: RO:0002104 PR:000001380 ! has plasma membrane part interleukin-2 receptor subunit alpha intersection_of: RO:0002215 GO:0050777 ! capable of negative regulation of immune response intersection_of: RO:0015016 PR:000001869 ! has low plasma membrane amount interleukin-7 receptor subunit alpha relationship: RO:0002104 PR:000001380 ! has plasma membrane part interleukin-2 receptor subunit alpha relationship: RO:0015016 PR:000001869 ! has low plasma membrane amount interleukin-7 receptor subunit alpha property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0000792" xsd:string {name="CD4-positive, CD25-positive, alpha-beta regulatory T cell on CELLxGENE CellGuide"} property_value: terms:description "The CD4-positive, CD25-positive, alpha-beta regulatory T (Treg) cell serves as a vital element in the mammalian immune system, playing a pivotal role in maintaining immune homeostasis and preventing autoimmunity. This particular T regulatory cell is characterized by CD4 proteins and a high level of CD25 (the alpha chain of the interleukin-2 receptor) on its cell surface. The T-cell receptor (TCR) of these Treg cells is composed of alpha and beta protein chains, making them a subtype of the alpha-beta T cell population that recognize and bind to antigens presented by MHC class II molecules.\nThe primary function of CD4-positive, CD25-positive, alpha-beta Treg cells is regulating immune responses, ensuring that the immune response is proportionate and preventing autoimmunity, maintaining peripheral immune tolerance, and limiting chronic inflammation. They achieve this regulation by suppressing or downregulating the proliferation of effector immune cells, which are activated in response to antigens, to prevent their excessive or uncontrolled activity. \nCD4-positive, CD25-positive, alpha-beta Treg cells can suppress immune responses via a variety of mechanisms, including the release of inhibitory cytokines, in particular IL-10 and TGFβ, or through cytolysis of effector immune cells (e.g. antibody-producing B cells) involving perforin and granzymes. They can also modulate the maturation or function of dendritic cells, which are key antigen-presenting cells, and thereby reduce their ability to stimulate effector T cells.\nThis downregulation also suppresses effector T cell functions against self-antigens—proteins that are innate to the body—to prevent autoimmunity. In essence, Treg cells act as a policing force within the immune system to maintain balance and prevent overreaction which can potentially lead to damaging effects.\nBesides their crucial role in preventing autoimmunity, CD4-positive, CD25-positive, alpha-beta Treg cells contribute to other functions such as tumor immune evasion, maternal-fetal tolerance, and transplantation tolerance. By suppressing the cytotoxic T cell response, these cells may inadvertently help tumor cells evade destruction, contributing to cancer progression. However, this characteristic can be potentially manipulated for therapeutic applications in immune-related diseases or transplantation, further highlighting the potential and importance of CD4-positive, CD25-positive, alpha-beta regulatory T cells in immune regulation.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1016/j.immuni.2019.01.020", xref="DOI:10.1038/nri2343", xref="DOI:10.1146/annurev-immunol-042718-041717", xref="DOI:10.3389/fimmu.2019.03100", xref="DOI:10.3389/fimmu.2021.750542"} [Term] id: CL:0000793 name: CD4-positive, alpha-beta intraepithelial T cell def: "A CD4-positive, alpha-beta T cell that is found in the columnar epithelium of the gastrointestinal tract." [GOC:add, GOC:tfm, ISBN:0781735149] subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "CD4-positive, alpha-beta intraepithelial T lymphocyte" EXACT [] synonym: "CD4-positive, alpha-beta intraepithelial T-cell" EXACT [] synonym: "CD4-positive, alpha-beta intraepithelial T-lymphocyte" EXACT [] synonym: "IEL" BROAD [] synonym: "intraepithelial lymphocyte" BROAD [] is_a: CL:0000624 {is_inferred="true"} ! CD4-positive, alpha-beta T cell is_a: CL:0000797 ! alpha-beta intraepithelial T cell intersection_of: CL:0000624 ! CD4-positive, alpha-beta T cell intersection_of: RO:0001025 UBERON:0001277 ! located in intestinal epithelium intersection_of: RO:0002215 GO:0002385 ! capable of mucosal immune response relationship: RO:0002202 CL:0000810 ! develops from CD4-positive, alpha-beta thymocyte property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0000794 name: CD8-positive, alpha-beta cytotoxic T cell def: "A CD8-positive, alpha-beta T cell that is capable of killing target cells in an antigen specific manner with the phenotype perforin-positive and granzyme B-positive." [GO_REF:0000031, GOC:add, GOC:pam, GOC:tfm, ISBN:0781735149] comment: Note that while T cells of this subset are loosely referred to 'cytotoxic T cells,' as many other T cell types, including CD4-positive, alpha-beta T cells and gamma-delta T cells exhibit cytotoxicity in vitro and in vivo. subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "CD8-positive, alpha-beta cytotoxic T lymphocyte" EXACT [] synonym: "CD8-positive, alpha-beta cytotoxic T-cell" EXACT [] synonym: "CD8-positive, alpha-beta cytotoxic T-lymphocyte" EXACT [] synonym: "cytotoxic T cell" BROAD [] synonym: "cytotoxic T lymphocyte" BROAD [] synonym: "cytotoxic T-cell" BROAD [] synonym: "cytotoxic T-lymphocyte" BROAD [] synonym: "killer T cell" BROAD [] synonym: "killer T lymphocyte" BROAD [] synonym: "killer T-cell" BROAD [] synonym: "killer T-lymphocyte" BROAD [] xref: CALOHA:TS-0190 is_a: CL:0000625 {is_inferred="true"} ! CD8-positive, alpha-beta T cell intersection_of: CL:0000625 ! CD8-positive, alpha-beta T cell intersection_of: BFO:0000051 PR:000003466 ! has part perforin-1 intersection_of: BFO:0000051 PR:000003499 ! has part granzyme B intersection_of: RO:0002215 GO:0001913 ! capable of T cell mediated cytotoxicity intersection_of: RO:0002215 GO:0033380 ! capable of granzyme B localization to T cell secretory granule intersection_of: RO:0002353 GO:0030217 ! output of T cell differentiation relationship: BFO:0000051 PR:000003466 ! has part perforin-1 relationship: BFO:0000051 PR:000003499 ! has part granzyme B relationship: RO:0002202 CL:0000906 ! develops from activated CD8-positive, alpha-beta T cell relationship: RO:0002215 GO:0001913 ! capable of T cell mediated cytotoxicity relationship: RO:0002215 GO:0033380 ! capable of granzyme B localization to T cell secretory granule relationship: RO:0002353 GO:0030217 ! output of T cell differentiation property_value: RO:0002175 NCBITaxon:9606 property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0000794" xsd:string {name="CD8-positive, alpha-beta cytotoxic T cell on CELLxGENE CellGuide"} property_value: terms:description "The CD8-positive, alpha-beta cytotoxic T cell plays a crucial role in the immune response system of vertebrates. A key feature of these cells is the expression of CD8, a transmembrane glycoprotein that serves as a co-receptor for the T cell receptor (TCR). Notably, the alpha-beta refers to the TCR heterodimer on the T cell, utilized to recognize the antigens displayed by Major Histocompatibility Complex (MHC) class I molecules on antigen-presenting cells.\nFunctioning primarily to combat intracellular pathogens, CD8+ T cells primarily seek and destroy cells infected by viruses or transformed by cancer. The TCR on the CD8+ T cell recognizes and binds to the antigen-MHC I complex displayed on the infected cell’s surface. Following this interaction, along with the engagement of co-stimulatory molecules, the T cell becomes activated. Upon activation, the CD8+ T cell proliferates and differentiates into cytotoxic T lymphocytes (CTL), ready to survey the body for the recognized antigen. \nCTLs employ two major cytotoxic mechanisms: the release of cytotoxic granules and the expression of death-inducing ligands on their surface. Cytotoxic granules contain perforin, a protein that forms pores in the targeted cell membrane, and granzymes, enzymes that trigger apoptosis inside the targeted cell through the activation of caspases. The Fas ligand and TRAIL death-inducing ligands on CTLs also bind to their respective receptors on the target cell and initiate a caspase cascade leading to cell death of the target. This cytotoxic function of the CD8+ alpha-beta T cell is critical in the control of infections and in cancer surveillance.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1038/s12276-023-01105-x", xref="DOI:10.3389/fimmu.2022.883010", xref="DOI:10.3389/fmolb.2021.628332", xref="https://www.sciencedirect.com/topics/biochemistry-genetics-and-molecular-biology/cytotoxic-t-cell"} [Term] id: CL:0000795 name: CD8-positive, alpha-beta regulatory T cell def: "A CD8-positive, alpha-beta T cell that regulates overall immune responses as well as the responses of other T cell subsets through direct cell-cell contact and cytokine release." [GOC:add, GOC:tfm, ISBN:0781735149] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "CD8+ regulatory T cell" EXACT [] synonym: "CD8+ T(reg)" EXACT [] synonym: "CD8+ Treg" EXACT [] synonym: "CD8-positive T(reg)" EXACT [] synonym: "CD8-positive Treg" EXACT [] synonym: "CD8-positive, alpha-beta regulatory T lymphocyte" EXACT [] synonym: "CD8-positive, alpha-beta regulatory T-cell" EXACT [] synonym: "CD8-positive, alpha-beta regulatory T-lymphocyte" EXACT [] synonym: "CD8-positive, alpha-beta Treg" EXACT [] synonym: "suppressor T cell" BROAD [] synonym: "suppressor T lymphocyte" BROAD [] synonym: "suppressor T-cell" BROAD [] synonym: "suppressor T-lymphocyte" BROAD [] is_a: CL:0000625 {is_inferred="true"} ! CD8-positive, alpha-beta T cell is_a: CL:0000815 ! regulatory T cell intersection_of: CL:0000625 ! CD8-positive, alpha-beta T cell intersection_of: RO:0002215 GO:0050777 ! capable of negative regulation of immune response [Term] id: CL:0000796 name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell def: "A alpha-beta intraepithelial T cell found in the columnar epithelium of the gastrointestinal tract. Intraepithelial T cells often have distinct developmental pathways and activation requirements." [GOC:add, ISBN:0781735149] subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "CD8-positive, alpha-beta intraepithelial T lymphocyte" EXACT [] synonym: "CD8-positive, alpha-beta intraepithelial T-cell" EXACT [] synonym: "CD8-positive, alpha-beta intraepithelial T-lymphocyte" EXACT [] synonym: "IEL" BROAD [] synonym: "intraepithelial lymphocyte" BROAD [] is_a: CL:0000797 {is_inferred="true"} ! alpha-beta intraepithelial T cell intersection_of: CL:0000797 ! alpha-beta intraepithelial T cell intersection_of: RO:0002104 PR:000025402 ! has plasma membrane part T cell receptor co-receptor CD8 relationship: RO:0002104 PR:000025402 ! has plasma membrane part T cell receptor co-receptor CD8 property_value: RO:0002175 NCBITaxon:9606 property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0000796" xsd:string {name="CD8-alpha-beta-positive, alpha-beta intraepithelial T cell on CELLxGENE CellGuide"} property_value: terms:description "CD8-alpha-beta-positive, alpha-beta intraepithelial T cells are subpopulation of αβ intraepithelial lymphocytes (IELs) which are predominately found in the intraepithelial layer of the intestine, skin and lung. They are characterized by the cell surface expression of both αβ T cell receptors (TCRs) and the CD8 αβ co-receptors, which are responsible for recognizing specific antigens expressed on the surface of pathogenic cells. \nThe primary function of CD8-alpha-beta-positive, alpha-beta intraepithelial T cells revolves around providing immune protection by targeting and eliminating cells infected with viruses or other pathogens. The TCR-CD8 complex on their surfaces recognizes major histocompatibility complex (MHC) class I molecules on infected cells. After recognition, the T cells bind to the infected cells and release cytotoxic agents that trigger apoptosis, leading to the death of the infected cells and effectively curbing the spread of the invading pathogen. This process also helps create a memory response for the same pathogens, enabling quicker responses in subsequent encounters.\nWith a majority of pathogens entering the body through the epithelial surfaces like skin and mucous membranes, having these T cells strategically located in these layers enables an effective first line of defense. Apart from pathogen detection and removal, they also contribute to maintaining tissue integrity and providing a surveillance mechanism against tumorigenic cells.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1038/s41385-018-0016-5", xref="DOI:10.1038/s41385-020-0294-6", xref="DOI:10.3389/fimmu.2022.1059042"} [Term] id: CL:0000797 name: alpha-beta intraepithelial T cell def: "A mature alpha-beta T cell of the columnar epithelium of the gastrointestinal tract. Intraepithelial T cells often have distinct developmental pathways and activation requirements." [GOC:add, GOC:tfm, ISBN:0781735149] subset: human_subset subset: mouse_subset synonym: "alpha-beta intraepithelial T lymphocyte" EXACT [] synonym: "alpha-beta intraepithelial T-cell" EXACT [] synonym: "alpha-beta intraepithelial T-lymphocyte" EXACT [] synonym: "IEL" BROAD [] synonym: "intraepithelial lymphocyte" BROAD [] is_a: CL:0000791 {is_inferred="true"} ! mature alpha-beta T cell is_a: CL:0002496 ! intraepithelial lymphocyte intersection_of: CL:0000791 ! mature alpha-beta T cell intersection_of: RO:0001025 UBERON:0001277 ! located in intestinal epithelium intersection_of: RO:0002215 GO:0002385 ! capable of mucosal immune response [Term] id: CL:0000798 name: gamma-delta T cell def: "A T cell that expresses a gamma-delta T cell receptor complex." [GOC:add, GOC:tfm, ISBN:0781735149] comment: Note that gamma-delta T cells have both thymic and extrathymic differentiation pathways. subset: blood_and_immune_upper_slim subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "gamma-delta T lymphocyte" EXACT [] synonym: "gamma-delta T-cell" EXACT [] synonym: "gamma-delta T-lymphocyte" EXACT [] synonym: "gammadelta T cell" EXACT [] synonym: "gd T cell" RELATED OMO:0003000 [] xref: ZFA:0009336 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000084 {is_inferred="true"} ! T cell intersection_of: CL:0000084 ! T cell intersection_of: RO:0002104 GO:0042106 ! has plasma membrane part gamma-delta T cell receptor complex relationship: RO:0002104 GO:0042106 ! has plasma membrane part gamma-delta T cell receptor complex property_value: RO:0002175 NCBITaxon:9606 property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0000798" xsd:string {name="gamma-delta T cell on CELLxGENE CellGuide"} property_value: terms:description "Gamma-delta T cells, also referred to as γδ T cells, are a distinct subset of T lymphocytes that play unique roles in the immune system. They are defined by expression of heterodimeric T-cell receptors (TCRs) comprised of γ and δ chains. They share characteristics with both innate and adaptive immune cells, and unlike alpha-beta (αβ) T cells, they do not require antigen processing and Major Histocompatibility Complex (MHC) presentation for the recognition of antigens. This unique response mechanism allows them to contribute to rapid immune responses, particularly in the context of tissue injury and infection.\nDepending on the γδ TCR and the context, different subsets of gamma-delta T cells perform a variety of functions which range from regulating thermogenesis in adipose tissue to controlling the plasticity of neuronal synapses in the central nervous system. A key function is in tissue homeostasis and surveillance against infectious agents and tumors. \nThey can carry out their defense role through several mechanisms, such as cytokine production, killing of target cells, and regulation of other immune cell responses. In response to pathogens, these cells produce a wide range of cytokines, including interferon-gamma (IFN-γ), tumor necrosis factor-alpha (TNF-α), and interleukin-17 (IL-17), which help recruit and activate other immune cells to the site of infection. Furthermore, gamma-delta T cells can directly kill infected cells or cancerous cells, which is instrumental in preventing the spread of infection or malignancy.\nDespite the broadly generalized role in immunity, the function of gamma-delta T cells can vastly vary depending on their tissue location. In the skin and mucosal tissues, they provide quick response to pathogens, while in secondary lymphoid organs, their regulatory functions shape the adaptive immune response. In recent years, their role in the context of autoimmunity and cancer has gained attention, with emerging studies suggesting their potential for immunotherapeutic interventions. Thus, gamma-delta T cells serve as vital components of the immune system, providing a versatile defense mechanism against a range of pathogenic targets.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1038/s41571-022-00722-1", xref="DOI:10.1038/s41577-020-00452-4", xref="DOI:10.1073/pnas.1818488116", xref="DOI:10.1146/annurev-immunol-032713-120216", xref="https://www.mdpi.com/journal/cells/special_issues/delta_T"} [Term] id: CL:0000799 name: immature gamma-delta T cell def: "A gamma-delta T cell that has an immature phenotype." [GOC:add, ISBN:0781735149] comment: Note that gamma-delta T cells have both thymic and extrathymic differentiation pathways. subset: human_subset subset: mouse_subset synonym: "immature gamma-delta T lymphocyte" EXACT [] synonym: "immature gamma-delta T-cell" EXACT [] synonym: "immature gamma-delta T-lymphocyte" EXACT [] xref: ZFA:0009337 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000798 {is_inferred="true"} ! gamma-delta T cell is_a: CL:0002420 ! immature T cell intersection_of: CL:0000798 ! gamma-delta T cell intersection_of: CL:4030044 GO:0042492 ! has_not_completed gamma-delta T cell differentiation intersection_of: CL:4030044 GO:0045058 ! has_not_completed T cell selection relationship: CL:4030044 GO:0042492 ! has_not_completed gamma-delta T cell differentiation relationship: RO:0002202 CL:0000807 ! develops from DN3 thymocyte [Term] id: CL:0000800 name: mature gamma-delta T cell def: "A gamma-delta T cell that has a mature phenotype. These cells can be found in tissues and circulation where they express unique TCR repertoire depending on their location." [GOC:add, GOC:tfm, ISBN:0781735149] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "mature gamma-delta T lymphocyte" EXACT [] synonym: "mature gamma-delta T-cell" EXACT [] synonym: "mature gamma-delta T-lymphocyte" EXACT [] xref: ZFA:0009338 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000798 {is_inferred="true"} ! gamma-delta T cell is_a: CL:0002419 ! mature T cell intersection_of: CL:0000798 ! gamma-delta T cell intersection_of: RO:0002353 GO:0045058 ! output of T cell selection relationship: RO:0002202 CL:0000799 ! develops from immature gamma-delta T cell property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0000800" xsd:string {name="mature gamma-delta T cell on CELLxGENE CellGuide"} property_value: terms:description "Mature gamma-delta (γδ) T-cells represent a distinct subgroup within the diverse T-cell lineage. They are rare in secondary lymphoid organs but enriched in many peripheral tissues, such as the intestines, lungs and skin, where they play key immunological roles in the protection against infections and tumors, tissue healing, and immune regulation. They are ‘unconventional’ T cells defined by the expression of T-cell receptors (TCRs) that are heterodimers composed of γ and δ chains.\nUnlike their alpha-beta (αβ) T-cell counterparts, which recognize antigens via Major Histocompatibility Complex (MHC) molecules, γδ T-cells are activated in an MHC-independent manner perceive their targets in a more direct manner, reacting to stress-induced self molecules or unprocessed antigens, providing a more rapid immune response.\nMature γδ T-cells derive from double-negative CD4− CD8− (DN) thymocytes, which can give rise to either αβ T or γδ T cell lineages. γδ T cells then develop from this precursor following a single selection step mediated by the γδ TCR; unlike cells in the αβ T cell lineage, they do not progress through to a double positive stage. Instead, most γδ T cells remain double-negative and develop into mature γδ T cells before they egress from the thymus.\nUpon maturation, γδ T-cells characteristics of both innate and adaptive immunity and can have both pro- and anti-inflammatory functions. Mature γδ T-cells fall into distinct IFNγ- and IL-17A-producing cell populations that can be distinguished by CD27 and CCR6 expression, respectively. The mature γδ T-cell population also includes γδ intraepithelial T-cells and dendritic epidermal T cells (DETCs), which are only present in the epidermis of rodents. \nThese phenotypically different mature γδ T-cells are functionally versatile. In addition to their role in immunosurveillance against microbes and tumor cells, aiding in early defense against invaders. They produce a cytokine and chemokine response and exert cytolysis of infected or transformed target cells (involving perforin and granzymes). They can assist with tissue repair in certain organs like the skin and muscle due to their ability to produce growth factors. In humans, specific γδ T-cells are able to serves as professional antigen presenting cells. Finally, because these cells are able to recognize and lyse tumors in an MHC-unrestricted manner, they have a huge potential for pan-population tumor immunotherapy.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1016/j.smim.2022.101662", xref="DOI:10.3389/fimmu.2020.00042", xref="DOI:10.3389/fimmu.2023.1106652"} [Term] id: CL:0000801 name: gamma-delta intraepithelial T cell def: "A mature gamma-delta T cell that is found in the columnar epithelium of the gastrointestinal tract. These cells participate in mucosal immune responses." [GOC:add, GOC:tfm, ISBN:0781735149] subset: human_subset subset: mouse_subset synonym: "gamma-delta intraepithelial T lymphocyte" EXACT [] synonym: "gamma-delta intraepithelial T-cell" EXACT [] synonym: "gamma-delta intraepithelial T-lymphocyte" EXACT [] synonym: "IEL" BROAD [] synonym: "intraepithelial lymphocyte" BROAD [] xref: ZFA:0009339 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000800 {is_inferred="true"} ! mature gamma-delta T cell is_a: CL:0002496 ! intraepithelial lymphocyte intersection_of: CL:0000800 ! mature gamma-delta T cell intersection_of: RO:0001025 UBERON:0001277 ! located in intestinal epithelium intersection_of: RO:0002215 GO:0002385 ! capable of mucosal immune response property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0000801" xsd:string {name="gamma-delta intraepithelial T cell on CELLxGENE CellGuide"} property_value: terms:description "Gamma-delta intraepithelial T cells, also known as γδ intraepithelial lymphocytes (IELs), are a unique subset of T cells residing in the epithelial layer of mucosal tissues such as the intestine and skin; more are found in intestinal intraepithelial tissue than in other tissues. They are characterized by their distinct T-cell receptor (TCR) that is composed of one gamma (γ) and one delta (δ) chain, unlike the conventional alpha-beta T cells. Most γδ IELs also express the CD8-alpha-alpha homodimer (Cd8-alpha alpha positive, gamma-delta intraepithelial T cells), although some are lacking both co-receptors CD4 and CD8 (CD4-negative CD8-negative gamma-delta intraepithelial T cells). γδ IELs are though to be ‘natural’ IELs as they acquire their activated phenotype in an ‘alternative’ self-antigen-based maturation process in the thymus. \nAlthough the function of γδ IELs is still not fully established, current evidence indicates that they serve as a crucial first line of defense against invading pathogens, thus making them an important class of immune cells at the epithelial barrier interfaces. γδ IELs respond to a variety of antigens, including those not recognized by conventional T cells. They are also thought to be involved in recruiting in immune surveillance by promoting homeostasis of host microbiota and in limiting excessive inflammation.\nIn addition to their primary role in immunity, γδ IELs also have roles in epithelial cell homeostasis and repair. They assist in maintaining the epithelial barrier by controlling the equilibrium of epithelial cell growth and death. They also contribute to the healing of lesions and the replacement of damaged epithelial cells. The regulative control exerted by γδ IELs over epithelial cell turnover indirectly influences immunity, underlining the complexity and versatility of these cells.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1038/s41385-020-0294-6", xref="DOI:10.3389/fimmu.2022.1059042", xref="DOI:10.3390/cells9030686"} [Term] id: CL:0000802 name: CD8-alpha alpha positive, gamma-delta intraepithelial T cell def: "A gamma-delta intraepithelial T cell that has the phenotype CD8-alpha alpha-positive." [GOC:add, GOC:tfm, ISBN:0781735149] subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "CD8-positive, gamma-delta intraepithelial T lymphocyte" EXACT [] synonym: "CD8-positive, gamma-delta intraepithelial T-cell" EXACT [] synonym: "CD8-positive, gamma-delta intraepithelial T-lymphocyte" EXACT [] synonym: "IEL" BROAD [] synonym: "intraepithelial lymphocyte" BROAD [] is_a: CL:0000801 {is_inferred="true"} ! gamma-delta intraepithelial T cell intersection_of: CL:0000801 ! gamma-delta intraepithelial T cell intersection_of: RO:0002104 PR:000001084 ! has plasma membrane part T-cell surface glycoprotein CD8 alpha chain relationship: RO:0002104 PR:000001084 ! has plasma membrane part T-cell surface glycoprotein CD8 alpha chain property_value: RO:0002175 NCBITaxon:9606 property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0000802" xsd:string {name="CD8-alpha alpha positive, gamma-delta intraepithelial T cell on CELLxGENE CellGuide"} property_value: terms:description "The CD8-alpha alpha positive, gamma-delta intraepithelial T cell are a subset of intraepithelial lymphocytes (IELs), a highly heterogeneous population of immune cell that resides within the epithelial layer of mucosal barriers. CD8-alpha alpha positive, gamma-delta intraepithelial T cell are predominantly found in the gastrointestinal tract. They are characterized by the expression of both CD8-alpha-alpha homodimer and the gamma-delta (γδ) variant of the T cell receptor (TCR). CD8-alpha alpha positive, gamma-delta are thought to represent the most typical γδ IEL subset in the intestine.\nThe IELs in the intestines are constantly and directly exposed to antigens in the gut lumen and form the first line of immune defense against invading pathogens. Unlike conventional T cells, IELs in the intestine are antigen-experienced and do not require priming. CD8-alpha alpha positive, gamma-delta intraepithelial T cells fall into a subgroup of ‘natural’ IELs, which acquire their activated phenotype in an ‘alternative’ self-antigen-based maturation process in the thymus. \nCD8-alpha alpha positive, gamma-delta intraepithelial T cell have several key functions. They help maintain the integrity of the epithelium and repair the epithelial barriers in response to physical and inflammatory injury by secreting various factors, including TGFβ1, TGFβ3 and keratinocyte growth factor (KGF). These cells also provide immediate, front-line defense against pathogens. They retain the ability to respond directly to stress-associated and infected cells independent of antigen-presenting cells and major histocompatibility complex molecules. They do this through recognition of antigens present on the surfaces of stressed or infected cells. Once activated, these cells initiate a rapid immune response by releasing cytotoxic granules and engaging death receptors, processes that eliminate harmful cells. Furthermore, CD8-alpha alpha positive, gamma-delta intraepithelial T cells have been implicated in regulatory functions, including in antibody class switching and immunoglobulin A (IgA) production and IL-10-dependent oral tolerance. \nDysregulation CD8-alpha alpha positive, gamma-delta intraepithelial T cells is linked to several inflammatory disorders including celiac disease, inflammatory bowel disease, and others. Therefore, the CD8-alpha alpha positive, gamma-delta intraepithelial T cell plays a significant role in not only direct pathogen defense but also in the maintenance of epithelial tissue integrity and homeostasis.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1038/nri.2017.101", xref="DOI:10.1038/nri3007", xref="DOI:10.3389/fimmu.2022.1059042", xref="DOI:10.3390/cells9030686"} [Term] id: CL:0000803 name: CD4-negative CD8-negative gamma-delta intraepithelial T cell def: "A gamma-delta intraepithelial T cell that has the phenotype CD4-negative and CD8-negative." [GOC:add, GOC:tfm, ISBN:0781735149] subset: human_subset subset: mouse_subset synonym: "CD4-positive, gamma-delta intraepithelial T lymphocyte" EXACT [] synonym: "CD4-positive, gamma-delta intraepithelial T-cell" EXACT [] synonym: "CD4-positive, gamma-delta intraepithelial T-lymphocyte" EXACT [] synonym: "IEL" BROAD [] synonym: "intraepithelial lymphocyte" BROAD [] is_a: CL:0000801 {is_inferred="true"} ! gamma-delta intraepithelial T cell intersection_of: CL:0000801 ! gamma-delta intraepithelial T cell intersection_of: CL:4030046 PR:000001004 ! lacks_plasma_membrane_part CD4 molecule intersection_of: CL:4030046 PR:000001084 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD8 alpha chain relationship: CL:4030046 PR:000001004 ! lacks_plasma_membrane_part CD4 molecule relationship: CL:4030046 PR:000001084 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD8 alpha chain [Term] id: CL:0000805 name: immature single positive thymocyte def: "A thymocyte that has the phenotype CD4-negative, CD8-positive, CD44-negative, CD25-negative, and pre-TCR-positive." [GO_REF:0000031, GOC:add, GOC:tfm, http://www.immgen.org/index_content.html, ISBN:0781735149] comment: Note that this type of thymocyte has passed the beta-selection checkpoint and is rapidly proliferating and rearranging the T cell receptor alpha chain and expressing the CD8 coreceptor. This stage comes between the DN4 and DP stages. subset: human_subset subset: mouse_subset synonym: "immature single positive T cell" EXACT [] synonym: "immature single positive T lymphocyte" EXACT [] synonym: "immature single positive T-lymphocyte" EXACT [] synonym: "ISP" EXACT [] synonym: "T.ISP.th" EXACT [] is_a: CL:0000893 {is_inferred="true"} ! thymocyte intersection_of: CL:0000893 ! thymocyte intersection_of: CL:4030046 PR:000001004 ! lacks_plasma_membrane_part CD4 molecule intersection_of: CL:4030046 PR:000001307 ! lacks_plasma_membrane_part CD44 molecule intersection_of: CL:4030046 PR:000001380 ! lacks_plasma_membrane_part interleukin-2 receptor subunit alpha intersection_of: RO:0002104 GO:0043384 ! has plasma membrane part pre-T cell receptor complex intersection_of: RO:0002104 PR:000025402 ! has plasma membrane part T cell receptor co-receptor CD8 intersection_of: RO:0015015 PR:000001932 ! has high plasma membrane amount signal transducer CD24 relationship: CL:4030046 PR:000001004 ! lacks_plasma_membrane_part CD4 molecule relationship: CL:4030046 PR:000001307 ! lacks_plasma_membrane_part CD44 molecule relationship: CL:4030046 PR:000001380 ! lacks_plasma_membrane_part interleukin-2 receptor subunit alpha relationship: RO:0002104 GO:0043384 ! has plasma membrane part pre-T cell receptor complex relationship: RO:0002104 PR:000025402 ! has plasma membrane part T cell receptor co-receptor CD8 relationship: RO:0002202 CL:0000808 ! develops from DN4 thymocyte relationship: RO:0015015 PR:000001932 ! has high plasma membrane amount signal transducer CD24 [Term] id: CL:0000806 name: DN2 thymocyte def: "A thymocyte that has the phenotype CD4-negative, CD8-negative, CD44-positive, and CD25-positive." [GO_REF:0000031, GOC:add, GOC:tfm, ISBN:0781735149] comment: Note that this type of thymocyte is at the earliest stage of T cell receptor rearrangement of the beta, gamma, and delta T cell receptor chains. Also, there is growing evidence that molecular markers characterizing double negative thymocytes are different across species, especially in mouse versus human thymus. If in doubt, please consider using CL:0002489 'double negative thymocyte'. subset: human_subset subset: mouse_subset synonym: "DN2 alpha-beta immature T lymphocyte" EXACT [] synonym: "DN2 alpha-beta immature T-cell" EXACT [] synonym: "DN2 alpha-beta immature T-lymphocyte" EXACT [] synonym: "DN2 cell" EXACT [] synonym: "DN2 immature T cell" EXACT [] synonym: "double negative 2" EXACT [] synonym: "preT.DN2.Th" EXACT [] synonym: "TN2 cell" EXACT [] synonym: "TN2 thymocyte" EXACT [] is_a: CL:0002489 ! double negative thymocyte intersection_of: CL:0000893 ! thymocyte intersection_of: CL:4030046 PR:000001004 ! lacks_plasma_membrane_part CD4 molecule intersection_of: CL:4030046 PR:000025402 ! lacks_plasma_membrane_part T cell receptor co-receptor CD8 intersection_of: RO:0002104 PR:000001307 ! has plasma membrane part CD44 molecule intersection_of: RO:0002104 PR:000001380 ! has plasma membrane part interleukin-2 receptor subunit alpha relationship: RO:0002104 PR:000001307 ! has plasma membrane part CD44 molecule relationship: RO:0002104 PR:000001380 ! has plasma membrane part interleukin-2 receptor subunit alpha relationship: RO:0002202 CL:0000894 ! develops from DN1 thymic pro-T cell [Term] id: CL:0000807 name: DN3 thymocyte def: "A thymocyte that has the phenotype CD4-negative, CD8-negative, CD44-negative, and CD25-positive and expressing the T cell receptor beta-chain in complex with the pre-T cell receptor alpha chain." [GO_REF:0000031, GOC:add, GOC:tfm, ISBN:0781735149] comment: There is growing evidence that molecular markers characterizing double negative thymocytes are different across species, especially in mouse versus human thymus. If in doubt, please consider using CL:0002489 'double negative thymocyte'. subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "DN3 alpha-beta immature T lymphocyte" EXACT [] synonym: "DN3 alpha-beta immature T-cell" EXACT [] synonym: "DN3 alpha-beta immature T-lymphocyte" EXACT [] synonym: "DN3 cell" EXACT [] synonym: "DN3 immature T cell" EXACT [] synonym: "double negative 3" EXACT [] synonym: "early cortical thymocyte" BROAD [] synonym: "preT.DN3.Th" EXACT [] synonym: "TN3 cell" EXACT [] synonym: "TN3 thymocyte" EXACT [] is_a: CL:0002489 ! double negative thymocyte intersection_of: CL:0000893 ! thymocyte intersection_of: CL:4030046 PR:000001004 ! lacks_plasma_membrane_part CD4 molecule intersection_of: CL:4030046 PR:000001307 ! lacks_plasma_membrane_part CD44 molecule intersection_of: CL:4030046 PR:000025402 ! lacks_plasma_membrane_part T cell receptor co-receptor CD8 intersection_of: RO:0002104 GO:0043384 ! has plasma membrane part pre-T cell receptor complex intersection_of: RO:0002104 PR:000001380 ! has plasma membrane part interleukin-2 receptor subunit alpha relationship: CL:4030046 PR:000001307 ! lacks_plasma_membrane_part CD44 molecule relationship: RO:0002104 GO:0043384 ! has plasma membrane part pre-T cell receptor complex relationship: RO:0002104 PR:000001380 ! has plasma membrane part interleukin-2 receptor subunit alpha relationship: RO:0002202 CL:0000806 ! develops from DN2 thymocyte [Term] id: CL:0000808 name: DN4 thymocyte def: "A thymocyte that has the phenotype CD4-negative, CD8-negative, CD44-negative, CD25-negative, and pre-TCR-positive." [GO_REF:0000031, GOC:add, GOC:tfm, ISBN:0781735149] comment: Note that this type of thymocyte has passed the beta-selection checkpoint and is rapidly proliferating and beginning to rearrange the T cell receptor alpha chain. There is growing evidence that molecular markers characterizing double negative thymocytes are different across species, especially in mouse versus human thymus. If in doubt, please consider using CL:0002489 'double negative thymocyte'. subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "DN4 alpha-beta immature T lymphocyte" EXACT [] synonym: "DN4 alpha-beta immature T-lymphocyte" EXACT [] synonym: "DN4 cell" EXACT [] synonym: "DN4 immature T cell" EXACT [] synonym: "DN4 immature T-cell" EXACT [] synonym: "double negative 4" EXACT [] synonym: "early cortical thymocyte" BROAD [] synonym: "T.DN4.th" EXACT [] is_a: CL:0002489 ! double negative thymocyte intersection_of: CL:0000893 ! thymocyte intersection_of: CL:4030046 PR:000001004 ! lacks_plasma_membrane_part CD4 molecule intersection_of: CL:4030046 PR:000001307 ! lacks_plasma_membrane_part CD44 molecule intersection_of: CL:4030046 PR:000001380 ! lacks_plasma_membrane_part interleukin-2 receptor subunit alpha intersection_of: CL:4030046 PR:000025402 ! lacks_plasma_membrane_part T cell receptor co-receptor CD8 intersection_of: RO:0002104 GO:0043384 ! has plasma membrane part pre-T cell receptor complex relationship: CL:4030046 PR:000001307 ! lacks_plasma_membrane_part CD44 molecule relationship: CL:4030046 PR:000001380 ! lacks_plasma_membrane_part interleukin-2 receptor subunit alpha relationship: RO:0002104 GO:0043384 ! has plasma membrane part pre-T cell receptor complex relationship: RO:0002202 CL:0000807 ! develops from DN3 thymocyte [Term] id: CL:0000809 name: double-positive, alpha-beta thymocyte def: "A thymocyte expressing the alpha-beta T cell receptor complex as well as both the CD4 and CD8 coreceptors." [GO_REF:0000031, GOC:add, GOC:tfm, ISBN:0781735149] comment: Thymocytes of this stage are undergoing positive and negative selection. subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "double-positive, alpha-beta immature T lymphocyte" EXACT [] synonym: "DP cell" EXACT [] synonym: "DP thymocyte" EXACT [] synonym: "late cortical thymocyte" BROAD [] is_a: CL:0000790 {is_inferred="true"} ! immature alpha-beta T cell is_a: CL:0000893 ! thymocyte intersection_of: CL:0000790 ! immature alpha-beta T cell intersection_of: BFO:0000050 UBERON:0002370 ! part of thymus intersection_of: RO:0002104 PR:000001004 ! has plasma membrane part CD4 molecule intersection_of: RO:0002104 PR:000025402 ! has plasma membrane part T cell receptor co-receptor CD8 relationship: RO:0002104 PR:000001004 ! has plasma membrane part CD4 molecule relationship: RO:0002104 PR:000025402 ! has plasma membrane part T cell receptor co-receptor CD8 relationship: RO:0002202 CL:0000805 ! develops from immature single positive thymocyte property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/2d-ftu/thymus-thymus-lobule/v1.3/assets/2d-ftu-thymus-thymus-lobule.png" xsd:string {terms:licence="http://creativecommons.org/licenses/by/4.0/", xref="doi:10.48539/HBM322.LZLG.752"} property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0000810 name: CD4-positive, alpha-beta thymocyte def: "An immature alpha-beta T cell that is located in the thymus and is CD4-positive and CD8-negative." [GO_REF:0000031, GOC:add, GOC:tfm, ISBN:0781735149] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "CD4-positive, alpha-beta immature T lymphocyte" EXACT [] synonym: "CD4-positive, alpha-beta immature T-cell" EXACT [] synonym: "CD4-positive, alpha-beta immature T-lymphocyte" EXACT [] synonym: "SP CD4 cell" EXACT [] is_a: CL:0000790 {is_inferred="true"} ! immature alpha-beta T cell is_a: CL:0000893 ! thymocyte intersection_of: CL:0000790 ! immature alpha-beta T cell intersection_of: BFO:0000050 UBERON:0002370 ! part of thymus intersection_of: CL:4030046 PR:000001084 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD8 alpha chain intersection_of: RO:0002104 PR:000001004 ! has plasma membrane part CD4 molecule relationship: CL:4030046 PR:000001084 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD8 alpha chain relationship: RO:0002104 PR:000001004 ! has plasma membrane part CD4 molecule relationship: RO:0002202 CL:0000809 ! develops from double-positive, alpha-beta thymocyte [Term] id: CL:0000811 name: CD8-positive, alpha-beta thymocyte def: "An immature alpha-beta T cell that is located in the thymus and is CD8-positive and CD4-negative." [GO_REF:0000031, GOC:add, GOC:tfm, ISBN:0781735149] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "CD8-positive, alpha-beta immature T cell" RELATED [] synonym: "CD8-positive, alpha-beta immature T lymphocyte" EXACT [] synonym: "CD8-positive, alpha-beta immature T-cell" EXACT [] synonym: "CD8-positive, alpha-beta immature T-lymphocyte" EXACT [] synonym: "SP CD8 cell" EXACT [] is_a: CL:0000790 {is_inferred="true"} ! immature alpha-beta T cell is_a: CL:0000893 ! thymocyte intersection_of: CL:0000790 ! immature alpha-beta T cell intersection_of: BFO:0000050 UBERON:0002370 ! part of thymus intersection_of: CL:4030046 PR:000001004 ! lacks_plasma_membrane_part CD4 molecule intersection_of: RO:0002104 PR:000025402 ! has plasma membrane part T cell receptor co-receptor CD8 relationship: CL:4030046 PR:000001004 ! lacks_plasma_membrane_part CD4 molecule relationship: RO:0002104 PR:000025402 ! has plasma membrane part T cell receptor co-receptor CD8 relationship: RO:0002202 CL:0000809 ! develops from double-positive, alpha-beta thymocyte [Term] id: CL:0000813 name: memory T cell def: "A long-lived, antigen-experienced T cell that has acquired a memory phenotype including distinct surface markers and the ability to differentiate into an effector T cell upon antigen reexposure." [GO_REF:0000031, GOC:add, GOC:pam, GOC:tfm, ISBN:0781735149] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "memory T lymphocyte" EXACT [] synonym: "memory T-cell" EXACT [] synonym: "memory T-lymphocyte" EXACT [] xref: BTO:0003435 xref: ZFA:0009342 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0002419 {is_inferred="true"} ! mature T cell intersection_of: CL:0002419 ! mature T cell intersection_of: RO:0000053 PATO:0001603 ! has characteristic increased life span intersection_of: RO:0002353 GO:0002286 ! output of T cell activation involved in immune response intersection_of: RO:0002353 GO:0043379 ! output of memory T cell differentiation disjoint_from: CL:0000898 ! naive T cell relationship: RO:0000053 PATO:0001603 ! has characteristic increased life span relationship: RO:0002353 GO:0043379 ! output of memory T cell differentiation [Term] id: CL:0000814 name: mature NK T cell def: "A mature alpha-beta T cell of a distinct lineage that bears natural killer markers and a T cell receptor specific for a limited set of ligands. NK T cells have activation and regulatory roles particularly early in an immune response." [GOC:add, ISBN:0781735149] subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "mature natural killer T cell" EXACT [] synonym: "mature natural killer T lymphocyte" EXACT [] synonym: "mature natural killer T-cell" EXACT [] synonym: "mature natural killer T-lymphocyte" EXACT [] synonym: "mature NK T lymphocyte" EXACT [] synonym: "mature NK T-cell" EXACT [] synonym: "mature NK T-lymphocyte" EXACT [] synonym: "mature NKT cell" EXACT [] is_a: CL:0000791 {is_inferred="true"} ! mature alpha-beta T cell intersection_of: CL:0000791 ! mature alpha-beta T cell intersection_of: RO:0002104 PR:000001874 ! has plasma membrane part KLRB1-like protein intersection_of: RO:0002215 GO:0032394 ! capable of MHC class Ib receptor activity intersection_of: RO:0002215 GO:0045087 ! capable of innate immune response intersection_of: RO:0002353 GO:0030217 ! output of T cell differentiation relationship: RO:0002104 PR:000001874 ! has plasma membrane part KLRB1-like protein relationship: RO:0002202 CL:0000914 ! develops from immature NK T cell relationship: RO:0002215 GO:0032394 ! capable of MHC class Ib receptor activity relationship: RO:0002215 GO:0045087 ! capable of innate immune response relationship: RO:0002353 GO:0030217 ! output of T cell differentiation property_value: RO:0002175 NCBITaxon:9606 property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0000814" xsd:string {name="mature NK T cell on CELLxGENE CellGuide"} property_value: terms:description "Mature NK T cells, or natural killer T cells, are a unique subset of alpha-beta T cells that serve as mediators in the immune response. They are named for their distinct ability to express markers typical of natural killer (NK) cells (such as NK1.1) as well as a T cell receptor specific for a limited set of ligands.\nSimilar to mature effector T cells, mature NK T cells represent a heterogeneous group of effector cells, which express different transcription factors and cytokines and hence have different effector functions in both innate and adaptive immune responses. They are CD1d-restricted T lymphocytes: they recognize endogenous and exogenous lipid antigens presented by the MHC-like molecule CD1d. They have been classified into two subpopulations based on their TCR usage and specificity for lipid antigen: Type I NK T cells have an invariant TCRα-chain while type II NK T cells have a more diverse TCR repertoire. \nMature NKT cells have been shown to have both pro- and anti-inflammatory functions and modulate immune responses, including cancer, autoimmunity, allergy, infection and graft-versus-host disease. The primary function of mature NK T cells is to rapidly respond to infections by releasing large amounts of cytokines to aid cell-to-cell communication in immune responses. They also play a role in recognizing and eliminating certain types of cancer cells. Upon activation via their TCRs, mature NK T cells can promptly release a plethora of cytokines including interferon-γ (IFN-γ) and interleukin-4 (IL-4). These cytokines subsequently stimulate other immune cells, such as B cells, T cells and macrophages, to respond to the infection or abnormal cell growth.\nIn addition to antibody-mediated responses, NK T cells are capable of cytotoxic responses, a crucial function in managing viral infections. Mature NK T cells can bind to infected cells, inducing cell death and thereby preventing the spread of the infection. Furthermore, they have been found to play an instrumental role in autoimmunity and allergic diseases, highlighting their key part in maintaining the body’s overall immune balance. Continuous research on mature NK T cells informs therapeutic efforts in immunological disorders, infections, and cancer.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1128/cmr.00232-20", xref="DOI:10.3389/fimmu.2018.00367", xref="DOI:10.3389/fncel.2019.00245", xref="https://www.ncbi.nlm.nih.gov/books/NBK532332/", xref="https://www.sciencedirect.com/topics/medicine-and-dentistry/natural-killer-t-cell"} [Term] id: CL:0000815 name: regulatory T cell def: "A T cell which regulates overall immune responses as well as the responses of other T cell subsets through direct cell-cell contact and cytokine release." [GO_REF:0000031, GOC:add] comment: This cell type may express FoxP3 and CD25 and secretes IL-10 and TGF-beta. subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "regulatory T lymphocyte" EXACT [] synonym: "regulatory T-cell" EXACT [] synonym: "regulatory T-lymphocyte" EXACT [] synonym: "suppressor T cell" BROAD [] synonym: "suppressor T lymphocyte" BROAD [] synonym: "suppressor T-cell" BROAD [] synonym: "suppressor T-lymphocyte" BROAD [] synonym: "Treg" EXACT [] xref: BTO:0004520 xref: FMA:84070 xref: MESH:D050378 is_a: CL:0002419 {is_inferred="true"} ! mature T cell intersection_of: CL:0002419 ! mature T cell intersection_of: RO:0002215 GO:0050777 ! capable of negative regulation of immune response relationship: RO:0002215 GO:0050777 ! capable of negative regulation of immune response property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0000816 name: immature B cell def: "An immature B cell is a B cell that has the phenotype surface IgM-positive and surface IgD-negative, and have not undergone class immunoglobulin class switching or peripheral encounter with antigen and activation." [GO_REF:0000031, GOC:add, GOC:dsd, GOC:rhs, GOC:tfm, ISBN:0781735149, PMID:20081059, PMID:20839338] comment: Immature B cells are also reportedly CD5-positive, CD10-positive, CD19-positive, CD20-positive, CD21-positive, CD22-positive, CD24-positive, CD25-negative, CD27-negative, CD34-negative, CD38-positive, CD40-positive, CD43-negative, CD45-positive, CD48-positive, CD53-positive, CD79a-positive, CD80-negative, CD81-positive, CD86-negative, CD95-negative, CD127-negative, CD138-negative, CD185-positive, CD196-positive, MHCII/HLA-DR-positive, RAG-positive, TdT-negative, Vpre-B-negative, and preBCR-negative. Transcription factors expressed: Pax5-positive. subset: blood_and_immune_upper_slim subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "immature B lymphocyte" EXACT [] synonym: "immature B-cell" EXACT [] synonym: "immature B-lymphocyte" EXACT [] synonym: "newly formed B cell" EXACT [ISBN:781735149] xref: ZFA:0009343 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0001201 ! B cell, CD19-positive intersection_of: CL:0001201 ! B cell, CD19-positive intersection_of: CL:4030044 GO:0045190 ! has_not_completed isotype switching intersection_of: CL:4030046 GO:0071738 ! lacks_plasma_membrane_part IgD immunoglobulin complex intersection_of: RO:0002104 GO:0071753 ! has plasma membrane part IgM immunoglobulin complex intersection_of: RO:0002104 PR:000001289 ! has plasma membrane part membrane-spanning 4-domains subfamily A member 1 relationship: CL:4030044 GO:0045190 ! has_not_completed isotype switching relationship: CL:4030046 GO:0071738 ! lacks_plasma_membrane_part IgD immunoglobulin complex relationship: RO:0002104 GO:0071753 ! has plasma membrane part IgM immunoglobulin complex relationship: RO:0002104 PR:000001289 ! has plasma membrane part membrane-spanning 4-domains subfamily A member 1 relationship: RO:0002202 CL:0000954 ! develops from small pre-B-II cell property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0000817 name: precursor B cell def: "A precursor B cell is a B cell with the phenotype CD10-positive." [GO_REF:0000031, GOC:rhs, GOC:tfm] subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "pre-B cell" RELATED [] xref: BTO:0001133 xref: CALOHA:TS-0819 xref: ZFA:0009344 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0001201 {is_inferred="true"} ! B cell, CD19-positive intersection_of: CL:0001201 ! B cell, CD19-positive intersection_of: CL:4030046 GO:0071753 ! lacks_plasma_membrane_part IgM immunoglobulin complex intersection_of: RO:0002104 PR:000001898 ! has plasma membrane part neprilysin disjoint_from: CL:0000826 ! pro-B cell relationship: CL:4030046 GO:0071753 ! lacks_plasma_membrane_part IgM immunoglobulin complex relationship: RO:0002104 PR:000001898 ! has plasma membrane part neprilysin property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0000818 name: transitional stage B cell def: "An immature B cell of an intermediate stage between the pre-B cell stage and the mature naive stage with the phenotype surface IgM-positive and CD19-positive, and are subject to the process of B cell selection. A transitional B cell migrates from the bone marrow into the peripheral circulation, and then to the spleen." [GO_REF:0000031, GOC:add, ISBN:0781735149, PMID:12810111, PMID:22343568] comment: This cell type is compatible with the HIPC Lyoplate markers for 'transitional B cell'. subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "T1 B cell" NARROW [] synonym: "T2 B cell" NARROW [] synonym: "T3 B cell" NARROW [] synonym: "transitional B cell" EXACT [PMID:22343568] synonym: "transitional stage B lymphocyte" EXACT [] synonym: "transitional stage B-cell" EXACT [] synonym: "transitional stage B-lymphocyte" EXACT [] xref: ZFA:0009345 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0001201 {is_inferred="true"} ! B cell, CD19-positive intersection_of: CL:0001201 ! B cell, CD19-positive intersection_of: CL:4030044 GO:0002335 ! has_not_completed mature B cell differentiation intersection_of: RO:0002104 GO:0071753 ! has plasma membrane part IgM immunoglobulin complex intersection_of: RO:0002104 PR:000001289 ! has plasma membrane part membrane-spanning 4-domains subfamily A member 1 intersection_of: RO:0015015 PR:000001408 ! has high plasma membrane amount ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 intersection_of: RO:0015015 PR:000001932 ! has high plasma membrane amount signal transducer CD24 relationship: CL:4030044 GO:0002335 ! has_not_completed mature B cell differentiation relationship: RO:0002104 GO:0071753 ! has plasma membrane part IgM immunoglobulin complex relationship: RO:0002104 PR:000001289 ! has plasma membrane part membrane-spanning 4-domains subfamily A member 1 relationship: RO:0002202 CL:0000816 ! develops from immature B cell relationship: RO:0015015 PR:000001408 ! has high plasma membrane amount ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 relationship: RO:0015015 PR:000001932 ! has high plasma membrane amount signal transducer CD24 property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0000819 name: B-1 B cell def: "A B cell of distinct lineage and surface marker expression. B-1 B cells are thought to be the primary source of natural IgM immunoglobulin, that is, IgM produced in large quantities without prior antigenic stimulation and generally reactive against various microorganisms, as well as the source of T-independent IgA immunoglobulin in the mucosal areas. These cells are CD43-positive." [GO_REF:0000031, GOC:add, GOC:dsd, http://en.wikipedia.org/wiki/B-1_cell, PMID:11861604, PMID:20933013, PMID:21220451] comment: There are small numbers of B-1 cells found in the lymph nodes and spleen, while larger numbers can be found in the peritoneal and pleural cavities. B-1 B cells are reportedly CD11b-positive, CD20-positive, CD21-positive, CD27-positive, CD44-positive, CD45RB-positive, CD48-positive, CD70-negative, CD150-positive, CD244-negative, CD352-positive, sIgM-positive, and sIgD-low. subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "B-1 B lymphocyte" EXACT [] synonym: "B-1 B-cell" EXACT [] synonym: "B-1 B-lymphocyte" EXACT [] synonym: "B-1 cell" EXACT [] synonym: "B1 B cell" EXACT [] synonym: "B1 B lymphocyte" EXACT [] synonym: "B1 B-cell" EXACT [] synonym: "B1 B-lymphocyte" EXACT [] synonym: "B1 cell" EXACT [] is_a: CL:0000785 {is_inferred="true"} ! mature B cell intersection_of: CL:0000785 ! mature B cell intersection_of: RO:0002104 PR:000001014 ! has plasma membrane part receptor-type tyrosine-protein phosphatase C isoform CD45RABC intersection_of: RO:0002104 PR:000001289 ! has plasma membrane part membrane-spanning 4-domains subfamily A member 1 intersection_of: RO:0002104 PR:000001879 ! has plasma membrane part leukosialin intersection_of: RO:0002215 GO:0045087 ! capable of innate immune response intersection_of: RO:0015015 GO:0071753 ! has high plasma membrane amount IgM immunoglobulin complex relationship: RO:0002104 PR:000001014 ! has plasma membrane part receptor-type tyrosine-protein phosphatase C isoform CD45RABC relationship: RO:0002104 PR:000001289 ! has plasma membrane part membrane-spanning 4-domains subfamily A member 1 relationship: RO:0002104 PR:000001879 ! has plasma membrane part leukosialin relationship: RO:0002215 GO:0045087 ! capable of innate immune response relationship: RO:0015015 GO:0071753 ! has high plasma membrane amount IgM immunoglobulin complex [Term] id: CL:0000820 name: B-1a B cell def: "A B-1 B cell that has the phenotype CD5-positive." [GOC:add, PMID:11861604] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "B-1a B lymphocyte" EXACT [] synonym: "B-1a B-cell" EXACT [] synonym: "B-1a B-lymphocyte" EXACT [] synonym: "B1a B cell" EXACT [] synonym: "B1a B lymphocyte" EXACT [] synonym: "B1a B-cell" EXACT [] synonym: "B1a B-lymphocyte" EXACT [] synonym: "B1a cell" EXACT [] synonym: "CD5(+) B1 cell" EXACT [] synonym: "CD5+ B1 cell" EXACT [] synonym: "CD5-positive B1 cell" EXACT [] is_a: CL:0000819 {is_inferred="true"} ! B-1 B cell intersection_of: CL:0000819 ! B-1 B cell intersection_of: RO:0002104 PR:000001839 ! has plasma membrane part T-cell surface glycoprotein CD5 relationship: RO:0002104 PR:000001839 ! has plasma membrane part T-cell surface glycoprotein CD5 [Term] id: CL:0000821 name: B-1b B cell def: "A B-1 B cell that has the phenotype CD5-negative, but having other phenotypic attributes of a B-1 B cell." [GOC:add, PMID:11861604] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "B-1b B lymphocyte" EXACT [] synonym: "B-1b B-cell" EXACT [] synonym: "B-1b B-lymphocyte" EXACT [] synonym: "B1b B cell" EXACT [] synonym: "B1b B lymphocyte" EXACT [] synonym: "B1b B-cell" EXACT [] synonym: "B1b B-lymphocyte" EXACT [] synonym: "B1b cell" EXACT [] is_a: CL:0000819 {is_inferred="true"} ! B-1 B cell intersection_of: CL:0000819 ! B-1 B cell intersection_of: CL:4030046 PR:000001839 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD5 relationship: CL:4030046 PR:000001839 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD5 [Term] id: CL:0000822 name: B-2 B cell def: "A conventional B cell subject to antigenic stimulation and dependent on T cell help and with a distinct surface marker expression pattern from B-1 B cells. These cells are CD43-negative." [GOC:add, GOC:dsd, GOC:tfm, ISBN:0781735149, PMID:11861604, PMID:20933013] comment: B-2 B cells are reportedly CD48-positive, CD244-negative, and CD352-positive. subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "B-0 B cell" RELATED [] synonym: "B-2 B lymphocyte" EXACT [] synonym: "B-2 B-cell" EXACT [] synonym: "B-2 B-lymphocyte" EXACT [] synonym: "B2 B cell" EXACT [] synonym: "B2 B lymphocyte" EXACT [] synonym: "B2 B-cell" EXACT [] synonym: "B2 B-lymphocyte" EXACT [] synonym: "B2 cell" EXACT [] is_a: CL:0000785 {is_inferred="true"} ! mature B cell intersection_of: CL:0000785 ! mature B cell intersection_of: CL:4030046 PR:000001879 ! lacks_plasma_membrane_part leukosialin intersection_of: RO:0002104 PR:000001289 ! has plasma membrane part membrane-spanning 4-domains subfamily A member 1 relationship: CL:4030046 PR:000001879 ! lacks_plasma_membrane_part leukosialin relationship: RO:0002104 PR:000001289 ! has plasma membrane part membrane-spanning 4-domains subfamily A member 1 [Term] id: CL:0000823 name: immature natural killer cell def: "A natural killer cell that is developmentally immature and expresses natural killer cell receptors (NKR)." [GO_REF:0000031, GOC:add, ISBN:0781735149, PMID:12457618] comment: In mouse the NKR are Ly49 molecules and in human these cells express KIR molecules. subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "immature NK cell" EXACT [] synonym: "p-NK" RELATED [PMID:12457618] xref: ZFA:0009346 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000623 ! natural killer cell is_a: CL:0001082 ! immature innate lymphoid cell intersection_of: CL:0000623 ! natural killer cell intersection_of: RO:0000053 PATO:0001501 ! has characteristic immature disjoint_from: CL:0000824 ! mature natural killer cell disjoint_from: CL:0000937 ! pre-natural killer cell relationship: RO:0002202 CL:0000937 ! develops from pre-natural killer cell [Term] id: CL:0000824 name: mature natural killer cell def: "A natural killer cell that is developmentally mature and expresses a variety of inhibitory and activating receptors that recognize MHC class I and other stress related molecules." [GO_REF:0000031, GOC:add, ISBN:0781735149, PMID:14685782] subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "LAK cell" BROAD [PMID:14685782] synonym: "lymphokine activated killer cell" BROAD [PMID:14685782] synonym: "mature NK cell" EXACT [] xref: ZFA:0009347 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000623 ! natural killer cell intersection_of: CL:0000623 ! natural killer cell intersection_of: RO:0000053 PATO:0001701 ! has characteristic mature relationship: RO:0000053 PATO:0001701 ! has characteristic mature relationship: RO:0002202 CL:0000823 ! develops from immature natural killer cell property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0000825 name: pro-NK cell def: "A lymphoid progenitor cell that is committed to the natural killer cell lineage, expressing CD122 (IL-15) receptor, but lacking many of the phenotypic characteristics of later stages of natural killer cell development such as expression of NK activating and inhibitory molecules. In human this cell has the phenotype CD34-positive, CD45RA-positive, CD10-positive, CD117-negative, and CD161 negative." [GO_REF:0000031, GOC:add, GOC:pam, PMID:11532393, PMID:12457618, PMID:15032583, PMID:15766674] comment: Most markers only described for human pro NK cells. subset: human_subset subset: mouse_subset synonym: "natural killer cell progenitor" EXACT [] synonym: "NKP" EXACT [PMID:12457618, PMID:15032583, PMID:15766674] synonym: "null cell" RELATED [PMID:11532393] synonym: "preNK cell" RELATED [PMID:11532393] synonym: "pro-natural killer cell" EXACT [] xref: ZFA:0009348 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000838 {is_inferred="true"} ! lymphoid lineage restricted progenitor cell intersection_of: CL:0000838 ! lymphoid lineage restricted progenitor cell intersection_of: CL:4030046 PR:000001874 ! lacks_plasma_membrane_part KLRB1-like protein intersection_of: CL:4030046 PR:000002065 ! lacks_plasma_membrane_part mast/stem cell growth factor receptor intersection_of: RO:0002104 PR:000001003 ! has plasma membrane part CD34 molecule intersection_of: RO:0002104 PR:000001015 ! has plasma membrane part receptor-type tyrosine-protein phosphatase C isoform CD45RA intersection_of: RO:0002104 PR:000001381 ! has plasma membrane part interleukin-2 receptor subunit beta intersection_of: RO:0002104 PR:000001898 ! has plasma membrane part neprilysin relationship: CL:4030046 PR:000001874 ! lacks_plasma_membrane_part KLRB1-like protein relationship: CL:4030046 PR:000002065 ! lacks_plasma_membrane_part mast/stem cell growth factor receptor relationship: RO:0002104 PR:000001003 ! has plasma membrane part CD34 molecule relationship: RO:0002104 PR:000001015 ! has plasma membrane part receptor-type tyrosine-protein phosphatase C isoform CD45RA relationship: RO:0002104 PR:000001381 ! has plasma membrane part interleukin-2 receptor subunit beta relationship: RO:0002104 PR:000001898 ! has plasma membrane part neprilysin relationship: RO:0002202 CL:0000051 ! develops from common lymphoid progenitor [Term] id: CL:0000826 name: pro-B cell def: "A progenitor cell of the B cell lineage, with some lineage specific activity such as early stages of recombination of B cell receptor genes, but not yet fully committed to the B cell lineage until the expression of PAX5 occurs." [GOC:add, GOC:dsd, ISBN:0781735149, PMID:12633665, PMID:16551251, PMID:18432934] comment: Human pro-B cells are reportedly CD10-positive, CD22-positive, CD34-positive, CD38-positive, CD45-low, CD48-positive, CD79a-positive, CD127-positive, CD184-positive, RAG-positive, TdT-positive, Vpre-B-positive, pre-BCR-negative, IgD-negative, and IgM-negative. Transcription factors expressed: Pax5-positive, EBF-positive, E2A-negative, Ikaros-negative, and PU.1-negative. subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "pre-B cell (Philadelphia nomenclature)" RELATED [PMID:11244048] synonym: "pre-pro B cell" BROAD [PMID:17582343] synonym: "pro-B lymphocyte" EXACT [] synonym: "pro-B-cell" EXACT [] synonym: "pro-B-lymphocyte" EXACT [] synonym: "progenitor B cell" EXACT [] synonym: "progenitor B lymphocyte" EXACT [] synonym: "progenitor B-cell" EXACT [] synonym: "progenitor B-lymphocyte" EXACT [] xref: BTO:0003104 xref: ZFA:0009349 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000838 {is_inferred="true"} ! lymphoid lineage restricted progenitor cell intersection_of: CL:0000838 ! lymphoid lineage restricted progenitor cell intersection_of: BFO:0000051 PR:000001903 ! has part paired box protein PAX-5 intersection_of: BFO:0000051 PR:000006611 ! has part DNA nucleotidylexotransferase intersection_of: RO:0000056 GO:0033152 ! participates in immunoglobulin V(D)J recombination relationship: BFO:0000051 PR:000001903 ! has part paired box protein PAX-5 relationship: BFO:0000051 PR:000006611 ! has part DNA nucleotidylexotransferase relationship: RO:0000056 GO:0033152 ! participates in immunoglobulin V(D)J recombination relationship: RO:0002202 CL:0000051 ! develops from common lymphoid progenitor property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0000827 name: pro-T cell def: "A lymphoid progenitor cell of the T cell lineage, with some lineage specific marker expression, but not yet fully committed to the T cell lineage." [GOC:add, ISBN:0781735149] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "DN1 cell" NARROW [] synonym: "DN1 thymocyte" NARROW [] synonym: "pro-T lymphocyte" EXACT [] synonym: "progenitor T cell" EXACT [] synonym: "TN1 cell" NARROW [] xref: ZFA:0009350 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000838 {is_inferred="true"} ! lymphoid lineage restricted progenitor cell intersection_of: CL:0000838 ! lymphoid lineage restricted progenitor cell intersection_of: RO:0002215 GO:0030217 ! capable of T cell differentiation relationship: RO:0002202 CL:0000051 ! develops from common lymphoid progenitor relationship: RO:0002215 GO:0030217 ! capable of T cell differentiation [Term] id: CL:0000828 name: thromboblast def: "A progenitor cell of the thrombocyte, a nucleated blood cell involved in coagulation typically seen in birds and other non-mammalian vertebrates." [GOC:add, GOC:tfm, PMID:7758949] comment: Note that this is a non-mammalian cell type. subset: human_subset subset: mouse_subset xref: ZFA:0009351 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000226 ! single nucleate cell is_a: CL:0000763 ! myeloid cell is_a: CL:0000839 {is_inferred="true"} ! myeloid lineage restricted progenitor cell intersection_of: CL:0000839 ! myeloid lineage restricted progenitor cell intersection_of: RO:0000053 PATO:0001407 ! has characteristic mononucleate intersection_of: RO:0002215 GO:0002574 ! capable of thrombocyte differentiation relationship: RO:0002202 CL:0000050 ! develops from megakaryocyte-erythroid progenitor cell relationship: RO:0002215 GO:0002574 ! capable of thrombocyte differentiation [Term] id: CL:0000829 name: basophilic myeloblast def: "A myeloblast committed to the basophil lineage." [GOC:add, ISBN:0721601464] subset: human_subset subset: mouse_subset is_a: CL:0000835 {is_inferred="true"} ! myeloblast intersection_of: CL:0000835 ! myeloblast intersection_of: RO:0002215 GO:0030221 ! capable of basophil differentiation relationship: RO:0002202 CL:0000613 ! develops from basophil progenitor cell relationship: RO:0002215 GO:0030221 ! capable of basophil differentiation [Term] id: CL:0000830 name: basophilic promyelocyte def: "A promyelocyte committed to the basophil lineage." [GOC:add, ISBN:0721601464] subset: human_subset subset: mouse_subset xref: FMA:84208 is_a: CL:0000836 {is_inferred="true"} ! promyelocyte intersection_of: CL:0000836 ! promyelocyte intersection_of: RO:0002215 GO:0030221 ! capable of basophil differentiation relationship: RO:0002202 CL:0000829 ! develops from basophilic myeloblast relationship: RO:0002215 GO:0030221 ! capable of basophil differentiation [Term] id: CL:0000831 name: mast cell progenitor def: "A progenitor cell of the mast cell lineage. Markers for this cell are FceRIa-low, CD117-positive, CD9-positive, T1/ST2-positive, SCA1-negative, and lineage-negative." [GOC:add, GOC:dsd, http://www.copewithcytokines.de, PMCID:PMC1183570, PMCID:PMC1312421, PMID:8629001, PMID:9354811] comment: MCP are CD16-positive, CD32-positive, CD34-positive, CD45-positive, integrin beta-7-positive, and lin-negative (CD2, CD3e, CD4, CD5, CD8a, CD14, CD19, CD20, CD27, integrin alpha-M, ly6c, ly6g, NCAM-1, and ter119). These cells also express the transcription factors GATA-1, GATA-2, and MITF, but not C/EBPa. subset: human_subset subset: mouse_subset synonym: "CFU-Mast" RELATED [] synonym: "CFU-MC" RELATED [] synonym: "colony forming unit mast cell" RELATED [] synonym: "MCP" EXACT [] is_a: CL:0000763 ! myeloid cell is_a: CL:0000839 {is_inferred="true"} ! myeloid lineage restricted progenitor cell intersection_of: CL:0000839 ! myeloid lineage restricted progenitor cell intersection_of: BFO:0000051 PR:000007857 ! has part erythroid transcription factor intersection_of: BFO:0000051 PR:000007858 ! has part endothelial transcription factor GATA-2 intersection_of: CL:4030045 PR:000005307 ! lacks_part CCAAT/enhancer-binding protein alpha intersection_of: CL:4030046 PR:000001002 ! lacks_plasma_membrane_part CD19 molecule intersection_of: CL:4030046 PR:000001004 ! lacks_plasma_membrane_part CD4 molecule intersection_of: CL:4030046 PR:000001012 ! lacks_plasma_membrane_part integrin alpha-M intersection_of: CL:4030046 PR:000001020 ! lacks_plasma_membrane_part CD3 epsilon intersection_of: CL:4030046 PR:000001024 ! lacks_plasma_membrane_part neural cell adhesion molecule 1 intersection_of: CL:4030046 PR:000001083 ! lacks_plasma_membrane_part CD2 molecule intersection_of: CL:4030046 PR:000001084 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD8 alpha chain intersection_of: CL:4030046 PR:000001289 ! lacks_plasma_membrane_part membrane-spanning 4-domains subfamily A member 1 intersection_of: CL:4030046 PR:000001839 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD5 intersection_of: CL:4030046 PR:000001889 ! lacks_plasma_membrane_part CD14 molecule intersection_of: CL:4030046 PR:000001963 ! lacks_plasma_membrane_part CD27 molecule intersection_of: CL:4030046 PR:000002978 ! lacks_plasma_membrane_part lymphocyte antigen 6G intersection_of: CL:4030046 PR:000002979 ! lacks_plasma_membrane_part lymphocyte antigen 6A-2/6E-1 intersection_of: CL:4030046 PR:000002980 ! lacks_plasma_membrane_part lymphocyte antigen 6C2 intersection_of: CL:4030046 PR:000002981 ! lacks_plasma_membrane_part lymphocyte antigen 76 (mouse) intersection_of: RO:0002104 PR:000005178 ! has plasma membrane part CD9 molecule intersection_of: RO:0002104 PR:000016401 ! has plasma membrane part transmembrane emp24 domain-containing protein 1 intersection_of: RO:0002215 GO:0060374 ! capable of mast cell differentiation intersection_of: RO:0015015 PR:000009143 ! has high plasma membrane amount integrin beta-7 intersection_of: RO:0015016 PR:000002065 ! has low plasma membrane amount mast/stem cell growth factor receptor intersection_of: RO:0015016 PR:000007431 ! has low plasma membrane amount high affinity immunoglobulin epsilon receptor subunit alpha relationship: BFO:0000051 PR:000007857 ! has part erythroid transcription factor relationship: BFO:0000051 PR:000007858 ! has part endothelial transcription factor GATA-2 relationship: CL:4030045 PR:000005307 ! lacks_part CCAAT/enhancer-binding protein alpha relationship: CL:4030046 PR:000001002 ! lacks_plasma_membrane_part CD19 molecule relationship: CL:4030046 PR:000001004 ! lacks_plasma_membrane_part CD4 molecule relationship: CL:4030046 PR:000001012 ! lacks_plasma_membrane_part integrin alpha-M relationship: CL:4030046 PR:000001020 ! lacks_plasma_membrane_part CD3 epsilon relationship: CL:4030046 PR:000001024 ! lacks_plasma_membrane_part neural cell adhesion molecule 1 relationship: CL:4030046 PR:000001083 ! lacks_plasma_membrane_part CD2 molecule relationship: CL:4030046 PR:000001084 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD8 alpha chain relationship: CL:4030046 PR:000001289 ! lacks_plasma_membrane_part membrane-spanning 4-domains subfamily A member 1 relationship: CL:4030046 PR:000001839 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD5 relationship: CL:4030046 PR:000001889 ! lacks_plasma_membrane_part CD14 molecule relationship: CL:4030046 PR:000001963 ! lacks_plasma_membrane_part CD27 molecule relationship: CL:4030046 PR:000002978 ! lacks_plasma_membrane_part lymphocyte antigen 6G relationship: CL:4030046 PR:000002979 ! lacks_plasma_membrane_part lymphocyte antigen 6A-2/6E-1 relationship: CL:4030046 PR:000002980 ! lacks_plasma_membrane_part lymphocyte antigen 6C2 relationship: CL:4030046 PR:000002981 ! lacks_plasma_membrane_part lymphocyte antigen 76 (mouse) relationship: RO:0002104 PR:000005178 ! has plasma membrane part CD9 molecule relationship: RO:0002104 PR:000016401 ! has plasma membrane part transmembrane emp24 domain-containing protein 1 relationship: RO:0002202 CL:0002028 ! develops from basophil mast progenitor cell relationship: RO:0002215 GO:0060374 ! capable of mast cell differentiation relationship: RO:0015015 PR:000009143 ! has high plasma membrane amount integrin beta-7 relationship: RO:0015016 PR:000002065 ! has low plasma membrane amount mast/stem cell growth factor receptor relationship: RO:0015016 PR:000007431 ! has low plasma membrane amount high affinity immunoglobulin epsilon receptor subunit alpha [Term] id: CL:0000832 name: eosinophilic myeloblast def: "A myeloblast committed to the eosinophil lineage." [GOC:add, ISBN:0721601464] subset: human_subset subset: mouse_subset is_a: CL:0000835 {is_inferred="true"} ! myeloblast intersection_of: CL:0000835 ! myeloblast intersection_of: RO:0002215 GO:0030222 ! capable of eosinophil differentiation relationship: RO:0002202 CL:0000611 ! develops from eosinophil progenitor cell relationship: RO:0002215 GO:0030222 ! capable of eosinophil differentiation [Term] id: CL:0000833 name: eosinophilic promyelocyte def: "A promyelocyte committed to the eosinophil lineage." [GOC:add, ISBN:0721601464] subset: human_subset subset: mouse_subset xref: FMA:84199 is_a: CL:0000836 {is_inferred="true"} ! promyelocyte intersection_of: CL:0000836 ! promyelocyte intersection_of: RO:0002215 GO:0030222 ! capable of eosinophil differentiation relationship: RO:0002202 CL:0000832 ! develops from eosinophilic myeloblast relationship: RO:0002215 GO:0030222 ! capable of eosinophil differentiation [Term] id: CL:0000834 name: neutrophil progenitor cell def: "A progenitor cell of the neutrophil lineage." [GOC:add, GOC:tfm, ISBN:0721601464] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "neutrophil stem cell" RELATED [] xref: ZFA:0009352 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000763 ! myeloid cell is_a: CL:0002191 {is_inferred="true"} ! granulocytopoietic cell intersection_of: CL:0002191 ! granulocytopoietic cell intersection_of: RO:0002215 GO:0030223 ! capable of neutrophil differentiation relationship: RO:0002202 CL:0000557 ! develops from granulocyte monocyte progenitor cell relationship: RO:0002215 GO:0030223 ! capable of neutrophil differentiation [Term] id: CL:0000835 name: myeloblast def: "The most primitive precursor in the granulocytic series, having fine, evenly distributed chromatin, several nucleoli, a high nuclear-to-cytoplasmic ration (5:1-7:1), and a nongranular basophilic cytoplasm. They reside in the bone marrow." [GOC:add, http://en.wikipedia.org/wiki/Myeloblast, http://www.cap.org, ISBN:0721601464] subset: human_subset subset: mouse_subset xref: BTO:0000187 xref: FMA:83524 xref: ZFA:0009353 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000763 ! myeloid cell is_a: CL:0002191 {is_inferred="true"} ! granulocytopoietic cell intersection_of: CL:0002191 ! granulocytopoietic cell intersection_of: BFO:0000051 CL:0017503 ! has part basophilic cytoplasm intersection_of: BFO:0000051 GO:0000791 ! has part euchromatin intersection_of: CL:4030045 GO:0042582 ! lacks_part azurophil granule intersection_of: RO:0000053 PATO:0040072 ! has characteristic high nuclear/cytoplasmic ratio relationship: BFO:0000051 CL:0017503 ! has part basophilic cytoplasm relationship: BFO:0000051 GO:0000791 ! has part euchromatin relationship: CL:4030045 GO:0042582 ! lacks_part azurophil granule relationship: RO:0000053 PATO:0040072 ! has characteristic high nuclear/cytoplasmic ratio relationship: RO:0002202 CL:0000557 ! develops from granulocyte monocyte progenitor cell [Term] id: CL:0000836 name: promyelocyte def: "A precursor in the granulocytic series, being a cell intermediate in development between a myeloblast and myelocyte, that has distinct nucleoli, a nuclear-to-cytoplasmic ratio of 5:1 to 3:1, and containing a few primary cytoplasmic granules. Markers for this cell are fucosyltransferase FUT4-positive, CD33-positive, integrin alpha-M-negative, low affinity immunoglobulin gamma Fc region receptor III-negative, and CD24-negative." [GOC:add, GOC:amm, GOC:tfm, http://www.cap.org, ISBN:0721601464] subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset xref: CALOHA:TS-0825 xref: FMA:83530 is_a: CL:0000763 ! myeloid cell is_a: CL:0002191 ! granulocytopoietic cell intersection_of: CL:0000839 ! myeloid lineage restricted progenitor cell intersection_of: BFO:0000051 CL:0017503 ! has part basophilic cytoplasm intersection_of: BFO:0000051 GO:0005730 ! has part nucleolus intersection_of: BFO:0000051 GO:0042582 ! has part azurophil granule intersection_of: CL:4030046 PR:000001012 ! lacks_plasma_membrane_part integrin alpha-M intersection_of: CL:4030046 PR:000001483 ! lacks_plasma_membrane_part low affinity immunoglobulin gamma Fc region receptor III intersection_of: CL:4030046 PR:000001932 ! lacks_plasma_membrane_part signal transducer CD24 intersection_of: RO:0000053 PATO:0040072 ! has characteristic high nuclear/cytoplasmic ratio intersection_of: RO:0002104 PR:000001456 ! has plasma membrane part alpha-(1,3)-fucosyltransferase 4 intersection_of: RO:0002104 PR:000001892 ! has plasma membrane part CD33 molecule relationship: BFO:0000051 CL:0017503 ! has part basophilic cytoplasm relationship: BFO:0000051 GO:0005730 ! has part nucleolus relationship: BFO:0000051 GO:0042582 ! has part azurophil granule relationship: CL:4030046 PR:000001012 ! lacks_plasma_membrane_part integrin alpha-M relationship: CL:4030046 PR:000001483 ! lacks_plasma_membrane_part low affinity immunoglobulin gamma Fc region receptor III relationship: CL:4030046 PR:000001932 ! lacks_plasma_membrane_part signal transducer CD24 relationship: RO:0000053 PATO:0040072 ! has characteristic high nuclear/cytoplasmic ratio relationship: RO:0002104 PR:000001456 ! has plasma membrane part alpha-(1,3)-fucosyltransferase 4 relationship: RO:0002104 PR:000001892 ! has plasma membrane part CD33 molecule relationship: RO:0002202 CL:0000835 ! develops from myeloblast property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0000837 name: hematopoietic multipotent progenitor cell def: "A hematopoietic multipotent progenitor cell is multipotent, but not capable of long-term self-renewal. These cells are characterized as lacking lineage cell surface markers and being CD34-positive in both mice and humans." [GOC:add, GOC:tfm, PMID:19022770] comment: Markers differ between mouse and human. subset: blood_and_immune_upper_slim subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "hemopoietic progenitor cell" EXACT [] synonym: "MPP" EXACT [] xref: BTO:0000725 xref: CALOHA:TS-0448 xref: ZFA:0009354 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: BFO:0000002 is_a: CL:0000255 ! eukaryotic cell is_a: CL:0008001 ! hematopoietic precursor cell intersection_of: CL:0000988 ! hematopoietic cell intersection_of: CL:4030046 PR:000001002 ! lacks_plasma_membrane_part CD19 molecule intersection_of: CL:4030046 PR:000001004 ! lacks_plasma_membrane_part CD4 molecule intersection_of: CL:4030046 PR:000001012 ! lacks_plasma_membrane_part integrin alpha-M intersection_of: CL:4030046 PR:000001020 ! lacks_plasma_membrane_part CD3 epsilon intersection_of: CL:4030046 PR:000001024 ! lacks_plasma_membrane_part neural cell adhesion molecule 1 intersection_of: CL:4030046 PR:000001083 ! lacks_plasma_membrane_part CD2 molecule intersection_of: CL:4030046 PR:000001084 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD8 alpha chain intersection_of: CL:4030046 PR:000001289 ! lacks_plasma_membrane_part membrane-spanning 4-domains subfamily A member 1 intersection_of: CL:4030046 PR:000001839 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD5 intersection_of: CL:4030046 PR:000001869 ! lacks_plasma_membrane_part interleukin-7 receptor subunit alpha intersection_of: CL:4030046 PR:000001889 ! lacks_plasma_membrane_part CD14 molecule intersection_of: CL:4030046 PR:000002978 ! lacks_plasma_membrane_part lymphocyte antigen 6G intersection_of: CL:4030046 PR:000002981 ! lacks_plasma_membrane_part lymphocyte antigen 76 (mouse) intersection_of: RO:0000053 PATO:0001402 ! has characteristic multipotent intersection_of: RO:0002104 PR:000001003 ! has plasma membrane part CD34 molecule disjoint_from: CL:0002032 ! hematopoietic oligopotent progenitor cell relationship: CL:4030046 PR:000001002 ! lacks_plasma_membrane_part CD19 molecule relationship: CL:4030046 PR:000001004 ! lacks_plasma_membrane_part CD4 molecule relationship: CL:4030046 PR:000001012 ! lacks_plasma_membrane_part integrin alpha-M relationship: CL:4030046 PR:000001020 ! lacks_plasma_membrane_part CD3 epsilon relationship: CL:4030046 PR:000001024 ! lacks_plasma_membrane_part neural cell adhesion molecule 1 relationship: CL:4030046 PR:000001083 ! lacks_plasma_membrane_part CD2 molecule relationship: CL:4030046 PR:000001084 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD8 alpha chain relationship: CL:4030046 PR:000001289 ! lacks_plasma_membrane_part membrane-spanning 4-domains subfamily A member 1 relationship: CL:4030046 PR:000001839 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD5 relationship: CL:4030046 PR:000001869 ! lacks_plasma_membrane_part interleukin-7 receptor subunit alpha relationship: CL:4030046 PR:000001889 ! lacks_plasma_membrane_part CD14 molecule relationship: CL:4030046 PR:000002978 ! lacks_plasma_membrane_part lymphocyte antigen 6G relationship: CL:4030046 PR:000002981 ! lacks_plasma_membrane_part lymphocyte antigen 76 (mouse) relationship: RO:0000053 PATO:0001402 ! has characteristic multipotent relationship: RO:0002104 PR:000001003 ! has plasma membrane part CD34 molecule relationship: RO:0002202 CL:0000037 ! develops from hematopoietic stem cell property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "hematopoietic multipotent progenitor cell" xsd:string [Term] id: CL:0000838 name: lymphoid lineage restricted progenitor cell def: "A progenitor cell restricted to the lymphoid lineage." [GOC:add, GOC:tfm] comment: Note that this is a class of cell types, not an identified single cell type. subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "lymphoid progenitor cell" BROAD [] xref: BTO:0004731 xref: CALOHA:TS-2025 xref: FMA:70338 xref: ZFA:0009355 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0002031 {is_inferred="true"} ! hematopoietic lineage restricted progenitor cell is_a: CL:0011026 ! progenitor cell intersection_of: CL:0002031 ! hematopoietic lineage restricted progenitor cell intersection_of: RO:0002215 GO:0030098 ! capable of lymphocyte differentiation disjoint_from: CL:0000839 ! myeloid lineage restricted progenitor cell relationship: RO:0002215 GO:0030098 ! capable of lymphocyte differentiation [Term] id: CL:0000839 name: myeloid lineage restricted progenitor cell def: "A progenitor cell restricted to the myeloid lineage." [GOC:add, GOC:tfm, PMID:19022770] comment: Note that this is a class of cell types, not an identified single cell type. subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "myeloid progenitor cell" BROAD [] xref: BTO:0004730 xref: CALOHA:TS-2099 xref: FMA:70339 xref: ZFA:0009356 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0002031 {is_inferred="true"} ! hematopoietic lineage restricted progenitor cell is_a: CL:0011026 ! progenitor cell intersection_of: CL:0002031 ! hematopoietic lineage restricted progenitor cell intersection_of: RO:0002215 GO:0030099 ! capable of myeloid cell differentiation relationship: RO:0002215 GO:0030099 ! capable of myeloid cell differentiation property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "myeloid lineage restricted progenitor cell" xsd:string [Term] id: CL:0000840 name: immature conventional dendritic cell def: "An immature cell of the conventional dendritic cell lineage, characterized by high levels of antigen uptake via endocytosis, macropinocytosis, and phagocytosis, and typically found resident in the tissues. Markers for this cell are CD80-low, CD86-low, and MHC-II-low." [GOC:add, GOC:tfm, PMID:9521319] subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "immature myeloid dendritic cell" NARROW [] is_a: CL:0000766 ! myeloid leukocyte is_a: CL:0000990 {is_inferred="true"} ! conventional dendritic cell intersection_of: CL:0000990 ! conventional dendritic cell intersection_of: RO:0015016 GO:0042613 ! has low plasma membrane amount MHC class II protein complex intersection_of: RO:0015016 PR:000001412 ! has low plasma membrane amount CD86 molecule intersection_of: RO:0015016 PR:000001438 ! has low plasma membrane amount CD80 molecule relationship: RO:0002202 CL:0001029 ! develops from common dendritic progenitor relationship: RO:0015016 GO:0042613 ! has low plasma membrane amount MHC class II protein complex relationship: RO:0015016 PR:000001412 ! has low plasma membrane amount CD86 molecule relationship: RO:0015016 PR:000001438 ! has low plasma membrane amount CD80 molecule property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0000841 name: mature conventional dendritic cell def: "A mature cell of the conventional dendritic cell lineage, characterized by a high capacity for antigen presentation and typically found in a lymph node." [GOC:add, GOC:tfm, PMID:9521319] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "mature dendritic cell" BROAD [GOC:add] synonym: "mature myeloid dendritic cell" NARROW [] xref: FMA:83038 is_a: CL:0000766 ! myeloid leukocyte is_a: CL:0000990 {is_inferred="true"} ! conventional dendritic cell intersection_of: CL:0000990 ! conventional dendritic cell intersection_of: RO:0002104 PR:000001310 ! has plasma membrane part CD83 molecule intersection_of: RO:0015015 GO:0042613 ! has high plasma membrane amount MHC class II protein complex intersection_of: RO:0015015 PR:000001412 ! has high plasma membrane amount CD86 molecule intersection_of: RO:0015015 PR:000001438 ! has high plasma membrane amount CD80 molecule relationship: RO:0002104 PR:000001310 ! has plasma membrane part CD83 molecule relationship: RO:0002202 CL:0000840 ! develops from immature conventional dendritic cell relationship: RO:0015015 GO:0042613 ! has high plasma membrane amount MHC class II protein complex relationship: RO:0015015 PR:000001412 ! has high plasma membrane amount CD86 molecule relationship: RO:0015015 PR:000001438 ! has high plasma membrane amount CD80 molecule [Term] id: CL:0000842 name: mononuclear leukocyte def: "A leukocyte with a single non-segmented nucleus in the mature form." [GOC:add] subset: blood_and_immune_upper_slim subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "mononuclear cell" EXACT [] synonym: "peripheral blood mononuclear cell" NARROW [] xref: BTO:0000878 xref: CALOHA:TS-0768 xref: FMA:86713 xref: ZFA:0009357 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000226 ! single nucleate cell is_a: CL:0000738 {is_inferred="true"} ! leukocyte intersection_of: CL:0000738 ! leukocyte intersection_of: RO:0000053 PATO:0001407 ! has characteristic mononucleate [Term] id: CL:0000843 name: follicular B cell def: "A resting mature B cell that has the phenotype IgM-positive, IgD-positive, CD23-positive and CD21-positive, and found in the B cell follicles of the white pulp of the spleen or the corticol areas of the peripheral lymph nodes. This cell type is also described as being CD19-positive, B220-positive, AA4-negative, CD43-negative, and CD5-negative." [GOC:add, GOC:dsd, http://en.wikipedia.org/wiki/Follicular_B_Cells, ISBN:0781735149, PMCID:PMC2193793, PMID:20933013] comment: Follicular B cells are also reportedly CD48-positive, CD84-positive, CD229-positive, and CD352-positive. subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "Fo B cell" EXACT [] synonym: "Fo B-cell" EXACT [] synonym: "follicular B lymphocyte" EXACT [] synonym: "follicular B-cell" EXACT [] synonym: "follicular B-lymphocyte" EXACT [] is_a: CL:0000822 ! B-2 B cell intersection_of: CL:0000785 ! mature B cell intersection_of: CL:4030046 PR:000001839 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD5 intersection_of: CL:4030046 PR:000001879 ! lacks_plasma_membrane_part leukosialin intersection_of: CL:4030046 PR:000002037 ! lacks_plasma_membrane_part complement component C1q receptor intersection_of: RO:0002104 GO:0071738 ! has plasma membrane part IgD immunoglobulin complex intersection_of: RO:0002104 GO:0071753 ! has plasma membrane part IgM immunoglobulin complex intersection_of: RO:0002104 PR:000001014 ! has plasma membrane part receptor-type tyrosine-protein phosphatase C isoform CD45RABC intersection_of: RO:0002104 PR:000001289 ! has plasma membrane part membrane-spanning 4-domains subfamily A member 1 intersection_of: RO:0002104 PR:000001338 ! has plasma membrane part complement receptor type 2 relationship: CL:4030046 PR:000001839 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD5 relationship: CL:4030046 PR:000002037 ! lacks_plasma_membrane_part complement component C1q receptor relationship: RO:0002104 GO:0071738 ! has plasma membrane part IgD immunoglobulin complex relationship: RO:0002104 GO:0071753 ! has plasma membrane part IgM immunoglobulin complex relationship: RO:0002104 PR:000001014 ! has plasma membrane part receptor-type tyrosine-protein phosphatase C isoform CD45RABC relationship: RO:0002104 PR:000001338 ! has plasma membrane part complement receptor type 2 [Term] id: CL:0000844 name: germinal center B cell def: "A rapidly cycling mature B cell that has distinct phenotypic characteristics and is involved in T-dependent immune responses and located typically in the germinal centers of lymph nodes. This cell type expresses Ly77 after activation." [GOC:add, GOC:dsd, GOC:tfm, ISBN:0781735149, PMID:19447676, PMID:20933013] comment: Germinal center B cells are also reportedly CD10-positive, CD19-positive, CD20-positive, CD38-positive, CD44-low, CD45-positive, CD48-positive, CD95-positive, CD352-positive, and HLA-DR-positive. Transcription factors: BCL6-positive, Ets1-positive, IRF8-positive, MTA3-positive, OBF1-positive, PAX5-positive, SpiB-positive, and STAT3-positive. subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "GC B cell" EXACT [] synonym: "GC B lymphocyte" EXACT [] synonym: "GC B-cell" EXACT [] synonym: "GC B-lymphocyte" EXACT [] synonym: "germinal center B lymphocyte" EXACT [] synonym: "germinal center B-cell" EXACT [] synonym: "germinal center B-lymphocyte" EXACT [] is_a: CL:0000785 {is_inferred="true"} ! mature B cell intersection_of: CL:0000785 ! mature B cell intersection_of: BFO:0000050 UBERON:0010754 ! part of germinal center intersection_of: RO:0002104 PR:000001289 ! has plasma membrane part membrane-spanning 4-domains subfamily A member 1 relationship: BFO:0000050 UBERON:0010754 ! part of germinal center relationship: RO:0002104 PR:000001289 ! has plasma membrane part membrane-spanning 4-domains subfamily A member 1 relationship: RO:0002202 CL:0000843 ! develops from follicular B cell property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0000845 name: marginal zone B cell of spleen def: "A mature B cell that is located in the marginal zone of the spleen with the phenotype CD23-negative and CD21-positive and expressing a B cell receptor usually reactive to bacterial cell wall components or senescent self components such as oxidized-LDL. This cell type is also described as being CD19-positive, B220-positive, IgM-high, AA4-negative, CD35-high." [GOC:add, GOC:dsd, http://en.wikipedia.org/wiki/Marginal-zone_B_cell, ISBN:0781735149, PMID:10933592, PMID:20933013] comment: MZ B cells are reportedly CD1-positive (mice), CD20-positive, CD48-positive, CD84-positive, CD150-positive, CD229-positive, and CD352-positive. subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "B cell of marginal zone of spleen" EXACT [] synonym: "marginal zone B cell" BROAD [] synonym: "marginal zone B lymphocyte" BROAD [] synonym: "marginal zone B-cell" BROAD [] synonym: "marginal zone B-lymphocyte" BROAD [] synonym: "marginal zone of spleen B cell" EXACT [] synonym: "MZ B cell" BROAD [] synonym: "MZ B lymphocyte" BROAD [] synonym: "MZ B-cell" BROAD [] synonym: "MZ B-lymphocyte" BROAD [] is_a: CL:0000785 {is_inferred="true"} ! mature B cell is_a: CL:2000074 ! splenocyte intersection_of: CL:0000785 ! mature B cell intersection_of: BFO:0000050 UBERON:0001251 ! part of marginal zone of spleen intersection_of: CL:4030046 PR:000001880 ! lacks_plasma_membrane_part low affinity immunoglobulin epsilon Fc receptor intersection_of: CL:4030046 PR:000002037 ! lacks_plasma_membrane_part complement component C1q receptor intersection_of: RO:0002104 PR:000001289 ! has plasma membrane part membrane-spanning 4-domains subfamily A member 1 intersection_of: RO:0002104 PR:000001338 ! has plasma membrane part complement receptor type 2 intersection_of: RO:0002215 GO:0042742 ! capable of defense response to bacterium intersection_of: RO:0015015 GO:0071753 ! has high plasma membrane amount IgM immunoglobulin complex relationship: BFO:0000050 UBERON:0001251 ! part of marginal zone of spleen relationship: CL:4030046 PR:000001880 ! lacks_plasma_membrane_part low affinity immunoglobulin epsilon Fc receptor relationship: CL:4030046 PR:000002037 ! lacks_plasma_membrane_part complement component C1q receptor relationship: RO:0002104 PR:000001289 ! has plasma membrane part membrane-spanning 4-domains subfamily A member 1 relationship: RO:0002104 PR:000001338 ! has plasma membrane part complement receptor type 2 relationship: RO:0002215 GO:0042742 ! capable of defense response to bacterium relationship: RO:0015015 GO:0071753 ! has high plasma membrane amount IgM immunoglobulin complex property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0000846 name: vestibular dark cell def: "An epithelial cell of the vestibular sensory organ that is characterized by intense enzymatic activities and numerous basal membrane infoldings." [PMID:11223304] subset: cellxgene_subset subset: human_subset subset: mouse_subset is_a: CL:0000066 ! epithelial cell [Term] id: CL:0000847 name: ciliated olfactory receptor neuron def: "An olfactory receptor cell in which the apical ending of the dendrite is a pronounced ciliated olfactory knob." [PMID:16841163] subset: human_subset subset: mouse_subset synonym: "ciliated olfactory sensory neuron" EXACT [] synonym: "ciliated sensory neuron" EXACT [] xref: ZFA:0009358 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000064 ! ciliated cell is_a: CL:0000207 ! olfactory receptor cell intersection_of: CL:0000207 ! olfactory receptor cell intersection_of: BFO:0000051 GO:0005929 ! has part cilium [Term] id: CL:0000848 name: microvillous olfactory receptor neuron def: "An olfactory receptor cell in which the apical ending of the dendrite is a knob that bears numerous microvilli." [PMID:16841163] subset: human_subset subset: mouse_subset synonym: "microvillous olfactory sensory neuron" EXACT [] synonym: "microvillous sensory neuron" RELATED [] xref: ZFA:0009359 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000207 ! olfactory receptor cell [Term] id: CL:0000849 name: crypt olfactory receptor neuron def: "An olfactory receptor cell with short cilia growing in an invagination bordered by microvilli." [PMID:16841163] subset: human_subset subset: mouse_subset synonym: "crypt cell" EXACT [] synonym: "crypt olfactory sensory neuron" EXACT [] synonym: "crypt sensory neuron" EXACT [] xref: ZFA:0009360 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000207 ! olfactory receptor cell [Term] id: CL:0000850 name: serotonergic neuron alt_id: CL:0000403 def: "A neuron that releases serotonin as a neurotransmitter." [SANBI:mhl] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "5-HT neuron" EXACT [] synonym: "5-hydroxytryptamine neuron" EXACT [] synonym: "serotinergic neuron" RELATED [] xref: FBbt:00005133 {sssom:mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"} xref: MESH:D059326 xref: WBbt:0006837 xref: ZFA:0009361 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000458 ! serotonin secreting cell is_a: CL:0000540 ! neuron intersection_of: CL:0000540 ! neuron intersection_of: RO:0002215 GO:0060096 ! capable of serotonin secretion, neurotransmission relationship: RO:0002215 GO:0060096 ! capable of serotonin secretion, neurotransmission [Term] id: CL:0000851 name: neuromast mantle cell def: "Neuromast mantle cell is a non-sensory cell. Neuromast mantle cells surround the neuromast support cells and neuromast hair cells, separating the neuromast from the epidermis, and secrete cupula in which the ciliary bundles of all the hair cells are embedded." [ISBN:0125296509] xref: ZFA:0009362 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000151 ! secretory cell is_a: CL:0000255 ! eukaryotic cell disjoint_from: CL:0000855 ! sensory hair cell relationship: BFO:0000050 UBERON:0008904 ! part of neuromast [Term] id: CL:0000852 name: neuromast supporting cell def: "Neuromast support cell is a non-sensory cell of the neuromast that extend between the sensory hair cells from the basement membrane to the apical surface; neuromast support cells are surrounded by neuromast mantle cells." [ISBN:0125296509] synonym: "neuromast support cell" EXACT [] xref: ZFA:0009363 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000255 ! eukaryotic cell is_a: CL:0000630 ! supporting cell disjoint_from: CL:0000855 ! sensory hair cell relationship: BFO:0000050 UBERON:0008904 ! part of neuromast [Term] id: CL:0000853 name: olfactory epithelial supporting cell def: "Olfactory epithelial support cell is a columnar cell that extends from the epithelial free margin to the basement membrane of the olfactory epithelium. This cell type has a large, vertically, elongate, euchromatic nucleus, along with other nuclei, forms a layer superficial to the cell body of the receptor cell; sends long somewhat irregular microvilli into the mucus layer; at the base, with expanded end-feet containing numerous lamellated dense bodies resembling lipofuscin of neurons." [GOC:tfm, ISBN:0517223651, SANBI:mhl] subset: human_subset subset: mouse_subset synonym: "olfactory epithelial support cell" EXACT [] synonym: "olfactory sustentacular cell" EXACT [] synonym: "supporting cell of olfactory epithelium" EXACT [] synonym: "sustentaculocyte of olfactory epithelium" EXACT [] xref: FMA:62302 xref: ZFA:0009364 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000630 ! supporting cell is_a: CL:0002167 ! olfactory epithelial cell intersection_of: CL:0000630 ! supporting cell intersection_of: BFO:0000050 UBERON:0001997 ! part of olfactory epithelium property_value: skos:prefLabel "olfactory epithelial supporting cell" xsd:string [Term] id: CL:0000854 name: interneuromast cell def: "Interneuromast cell is a neuroectodermal cell deposited by the migrating lateral line primordium between the neuromasts. Interneuromast cells proliferate and migrate to form additional neuromasts." [SANBI:mhl] subset: human_subset subset: mouse_subset xref: ZFA:0009365 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: BFO:0000002 is_a: CL:0000133 ! neurectodermal cell relationship: RO:0002202 CL:0000032 ! develops from neuroplacodal cell [Term] id: CL:0000855 name: sensory hair cell def: "Hair cell is a mechanoreceptor cell that is sensitive to movement of the hair-like projections (stereocilia and kinocilia) which relay the information centrally in the nervous system." [SANBI:mhl] subset: human_subset subset: mouse_subset synonym: "hair cell" BROAD [] xref: BTO:0004744 xref: ZFA:0009366 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000199 ! mechanoreceptor cell [Term] id: CL:0000856 name: neuromast hair cell def: "Neuromast hair cell is a hair cell that acts as a sensory receptor of the neuromast; it is morphologically polarized as a result of the relative position of the single kinocilium and the clusters of stereocilia on its apical surface." [SANBI:mhl] xref: ZFA:0009367 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000006 ! neuronal receptor cell is_a: CL:0000855 ! sensory hair cell intersection_of: CL:0000855 ! sensory hair cell intersection_of: BFO:0000050 UBERON:0008904 ! part of neuromast relationship: BFO:0000050 UBERON:0008904 ! part of neuromast [Term] id: CL:0000857 name: slow muscle myoblast def: "A skeletal muscle myoblast that differentiates into slow muscle fibers." [SANBI:mhl] subset: human_subset subset: mouse_subset xref: ZFA:0009368 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000515 ! skeletal muscle myoblast intersection_of: CL:0000056 ! myoblast intersection_of: RO:0002203 CL:0000189 ! develops into slow muscle cell relationship: RO:0002203 CL:0000189 ! develops into slow muscle cell [Term] id: CL:0000858 name: fast muscle myoblast def: "A skeletal muscle myoblast that differentiates into fast muscle fibers." [SANBI:mhl] subset: human_subset subset: mouse_subset xref: ZFA:0009369 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000515 ! skeletal muscle myoblast intersection_of: CL:0000056 ! myoblast intersection_of: RO:0002203 CL:0000190 ! develops into fast muscle cell relationship: RO:0002203 CL:0000190 ! develops into fast muscle cell [Term] id: CL:0000860 name: classical monocyte def: "A monocyte that responds rapidly to microbial stimuli by secreting cytokines and antimicrobial factors and which is characterized by high expression of CCR2 in both rodents and humans, negative for the lineage markers CD3, CD19, and CD20, and of larger size than non-classical monocytes." [GO_REF:0000031, GOC:add, PMID:16322748, PMID:18303997, PMID:20628149, PMID:20870168] comment: Markers: CCR2+CXCCR1 (human, mouse, rat). subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "inflammatory monocyte" EXACT [] is_a: CL:0000576 {is_inferred="true"} ! monocyte intersection_of: CL:0000576 ! monocyte intersection_of: CL:4030046 PR:000001002 ! lacks_plasma_membrane_part CD19 molecule intersection_of: CL:4030046 PR:000001020 ! lacks_plasma_membrane_part CD3 epsilon intersection_of: CL:4030046 PR:000001289 ! lacks_plasma_membrane_part membrane-spanning 4-domains subfamily A member 1 intersection_of: RO:0002215 GO:0002548 ! capable of monocyte chemotaxis intersection_of: RO:0002215 GO:0006909 ! capable of phagocytosis intersection_of: RO:0002215 GO:0006954 ! capable of inflammatory response intersection_of: RO:0015015 PR:000001199 ! has high plasma membrane amount C-C chemokine receptor type 2 relationship: CL:4030046 PR:000001002 ! lacks_plasma_membrane_part CD19 molecule relationship: CL:4030046 PR:000001020 ! lacks_plasma_membrane_part CD3 epsilon relationship: CL:4030046 PR:000001289 ! lacks_plasma_membrane_part membrane-spanning 4-domains subfamily A member 1 relationship: RO:0002215 GO:0002548 ! capable of monocyte chemotaxis relationship: RO:0002215 GO:0006954 ! capable of inflammatory response relationship: RO:0015015 PR:000001199 ! has high plasma membrane amount C-C chemokine receptor type 2 property_value: RO:0002175 NCBITaxon:9606 property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0000860" xsd:string {name="classical monocyte on CELLxGENE CellGuide"} property_value: terms:description "Classical monocytes are a subtype of monocytes that are characterized by high CD14 but no CD16 expression. Emerging from the bone marrow and entering the bloodstream, these cells play central roles in immune responses and regulation of inflammation. CD14-positive CD16-negative monocytes form the majority of circulating monocytes in the body, typically contributing to around 80-90% of the total monocyte pool. \nThe primary function of the classical monocytes is to serve in the frontline of host defense against infections. They are primed to migrate to sites of infection, and they express pattern recognition receptors that help them identify and phagocytose pathogens, leading to their destruction. Classical monocytes also contribute to inflammation by producing several pro-inflammatory cytokines including interleukins and tumor necrosis factors. \nIn response to specific signals from tissues under pathological conditions, such as infection or injury, classical monocytes can leave the bloodstream and migrate towards the affected sites. Following their arrival, these cells differentiate into diverse cell types including macrophages and dendritic cells to combat specific pathogens or injury. Dysregulated monocyte activity can lead to the development of many human diseases including inflammation, infection, tissue injury, and various autoimmune diseases.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1038/nri.2017.28", xref="DOI:10.1111/sji.12883", xref="DOI:10.1182/blood-2009-07-235028", xref="DOI:10.3389/fimmu.2015.00423/full", xref="DOI:10.3389/fimmu.2019.02035"} [Term] id: CL:0000861 name: elicited macrophage def: "A macrophage which develops from an inflammatory monocyte and is recruited into the tissues in response to injury and infection as part of an inflammatory response. Markers include CD11b-positive, CD68-positive, and F4/80-positive." [GO_REF:0000031, GOC:add, GOC:ana, GOC:tfm, PMID:15771589] comment: Markers: CD11b+, CD68+; Mouse: F4/80+; role or process: immune, inflammation (inflammatory response). subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "free macrophage" EXACT [] synonym: "wandering histiocyte" EXACT [] xref: FMA:84643 xref: FMA:84645 is_a: CL:0000235 {is_inferred="true"} ! macrophage intersection_of: CL:0000235 ! macrophage intersection_of: RO:0000056 GO:0006954 ! participates in inflammatory response intersection_of: RO:0002104 PR:000001012 ! has plasma membrane part integrin alpha-M intersection_of: RO:0002104 PR:000001813 ! has plasma membrane part adhesion G protein-coupled receptor E1 intersection_of: RO:0002104 PR:000002064 ! has plasma membrane part macrosialin relationship: RO:0000056 GO:0006954 ! participates in inflammatory response relationship: RO:0002104 PR:000001012 ! has plasma membrane part integrin alpha-M relationship: RO:0002104 PR:000001813 ! has plasma membrane part adhesion G protein-coupled receptor E1 relationship: RO:0002104 PR:000002064 ! has plasma membrane part macrosialin relationship: RO:0002202 CL:0000860 ! develops from classical monocyte [Term] id: CL:0000862 name: suppressor macrophage def: "A macrophage that suppresses immune responses." [GOC:add, GOC:tfm, PMID:20402419] comment: Markers: May express: IL10, TGFbeta. subset: human_subset subset: mouse_subset is_a: CL:0000861 {is_inferred="true"} ! elicited macrophage intersection_of: CL:0000861 ! elicited macrophage intersection_of: RO:0002215 GO:0050777 ! capable of negative regulation of immune response relationship: RO:0002215 GO:0050777 ! capable of negative regulation of immune response [Term] id: CL:0000863 name: M1 macrophage def: "An elicited macrophage that is recruited into the tissues in response to injury and infection as part of an inflammatory response, expresses high levels of pro-inflammatory cytokines, ROS and NO, and shows potent microbicidal activity." [GO_REF:0000031, GOC:ana, PMID:19132917] comment: Markers: Express: TNFa, IL1b, IL6, iNOS, NADPH-oxidase; produce: reactive oxygen species, nitric oxide; role or process: immune, inflammation (inflammatory response). subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "classically activated macrophage" EXACT [PMID:30861466] synonym: "inflammatory macrophage" EXACT [] is_a: CL:0000861 {is_inferred="true"} ! elicited macrophage intersection_of: CL:0000861 ! elicited macrophage intersection_of: RO:0002215 GO:0032611 ! capable of interleukin-1 beta production intersection_of: RO:0002215 GO:0032635 ! capable of interleukin-6 production intersection_of: RO:0002215 GO:0032640 ! capable of tumor necrosis factor production intersection_of: RO:0002215 GO:0042554 ! capable of superoxide anion generation intersection_of: RO:0002215 GO:0042742 ! capable of defense response to bacterium intersection_of: RO:0002215 GO:0045428 ! capable of regulation of nitric oxide biosynthetic process relationship: RO:0002202 CL:0020017 ! develops from M0 macrophage relationship: RO:0002215 GO:0032611 ! capable of interleukin-1 beta production relationship: RO:0002215 GO:0032635 ! capable of interleukin-6 production relationship: RO:0002215 GO:0032640 ! capable of tumor necrosis factor production relationship: RO:0002215 GO:0042554 ! capable of superoxide anion generation relationship: RO:0002215 GO:0042742 ! capable of defense response to bacterium relationship: RO:0002215 GO:0045428 ! capable of regulation of nitric oxide biosynthetic process property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0000863" xsd:string {name="M1 macrophage on CELLxGENE CellGuide"} property_value: terms:description "Inflammatory macrophages, also sometimes referred to as M1 or classically activated macrophages, play an important role in the inflammatory response. The M1/M2 classification is based upon macrophage polarization rather than macrophage location and refers to macrophage activation towards either a more inflammatory or more resolving phenotype, respectively, although the functional diversity of macrophages is more nuanced than such a dichotomy suggests.\nInflammatory macrophages are derived from monocytes recruited to a site of infection or injury. M1 macrophages are classically activated, typically by IFN-γ or lipopolysaccharide (LPS). Upon sensing signs of inflammation, they quickly respond by increasing their pro-inflammatory activity. They achieve this by producing a range of signaling molecules, such as nitric oxide, reactive oxygen species, and numerous cytokines such as tumor necrosis factor-alpha (TNF-alpha) and interleukin-1, -6 and -12. The release of these potent molecules helps to recruit other immune cells to the site, killing off pathogenic organisms and facilitation inflammation. At the same time, M1 macrophages can also present antigens to T cells, thereby helping to induce an adaptive immune response. Over time, these macrophages may transition in phenotype and function to help resolve the inflammation and promote tissue repair.\nDespite the beneficial role of inflammatory macrophages in dealing with pathogens, chronic activation of these cells can lead to harmful effects. Over time, continuous production of pro-inflammatory molecules can cause damage to tissues and organs. This is seen in certain chronic inflammatory diseases, such as atherosclerosis, diabetes, obesity, asthma, and various autoimmune disorders. In such situations, the normally protective function of inflammatory macrophages is not properly controlled, which can contribute to disease pathology.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1038/s41392-023-01452-1", xref="DOI:10.1186/s12935-021-02089-2", xref="DOI:10.3389/fimmu.2015.00263", xref="DOI:10.3389/fimmu.2020.583084"} [Term] id: CL:0000864 name: tissue-resident macrophage def: "A macrophage constitutively resident in a particular tissue under non-inflammatory conditions, and capable of phagocytosing a variety of extracellular particulate material, including immune complexes, microorganisms, and dead cells." [GO_REF:0000031, GOC:ana, PMID:19770654] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "fixed macrophage" EXACT [] synonym: "resting histiocyte" EXACT [] xref: FMA:84642 xref: FMA:84644 is_a: CL:0000235 {is_inferred="true"} ! macrophage intersection_of: CL:0000235 ! macrophage intersection_of: BFO:0000050 UBERON:0000479 ! part of tissue relationship: BFO:0000050 UBERON:0000479 ! part of tissue property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0000864" xsd:string {name="tissue-resident macrophage on CELLxGENE CellGuide"} property_value: terms:description "Tissue-resident macrophages refer to a heterogeneous group of specialized macrophages that permanently reside within specific tissues, performing integral functions essential to tissue homeostasis. Most tissue-resident macrophages arise from embryonic populations and self-renew. Some macrophages may also originate from circulating monocytes released from the bone marrow and differentiate into macrophages upon entering tissue. Tissue-resident macrophages are given different names depending upon the tissue in which they reside, such as Kupffer cells in the liver, alveolar macrophages in the lungs, and microglia in the brain.\nTissue-resident macrophages are responsible for the phagocytosis of pathogenic substances and dead cells, serving as part of the foremost line of defense against invading microorganisms. They utilize pattern recognition receptors to identify foreign substances and function as antigen-presenting cells to induce adaptive immunity. Additionally, they produce a variety of cytokines and chemokines, signaling molecules that recruit additional immune cells to sites of infection or inflammation and regulate immune responses.\nIn addition to their immunological roles, tissue-resident macrophages also have tissue-unique functions. In the liver, Kupffer cells play a role in iron homeostasis, while in the brain, microglia are responsible for synaptic pruning during development. In the lungs, alveolar macrophages are involved in the removal of airborne particles and debris. This underscores their significance in not only providing pathological immunity but also in maintaining the optimal function of the tissues in which they reside. \"\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1016/j.immuni.2016.02.015", xref="DOI:10.1038/s41392-023-01452-1", xref="DOI:10.1093/intimm/dxy054", xref="DOI:10.1146/annurev-immunol-032414-112220"} [Term] id: CL:0000865 name: gastrointestinal tract (lamina propria) macrophage def: "A gut-associated lymphoid tissue macrophage found in lamina propria of the gut." [GO_REF:0000031, GOC:ana, GOC:tfm, https://orcid.org/0000-0002-2825-0621] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "gastrointestinal system (lamina propria) macrophage" EXACT [] synonym: "macrophage of gastrointestinal system (lamina propria)" EXACT [] synonym: "macrophage of gastrointestinal tract (lamina propria)" EXACT [] is_a: CL:0000885 ! gut-associated lymphoid tissue macrophage intersection_of: CL:0000885 ! gut-associated lymphoid tissue macrophage intersection_of: BFO:0000050 UBERON:0004780 ! part of gastrointestinal system lamina propria relationship: BFO:0000050 UBERON:0004780 ! part of gastrointestinal system lamina propria [Term] id: CL:0000866 name: thymic macrophage def: "A tissue-resident macrophage resident found in the thymus, involved in the clearance of apoptotic thymocytes." [GO_REF:0000031, GOC:ana, GOC:tfm, PMID:9048205] comment: Role or process: immune, clearance of apoptotic thymocytes, antigen-presentation. subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset is_a: CL:0000864 {is_inferred="true"} ! tissue-resident macrophage intersection_of: CL:0000864 ! tissue-resident macrophage intersection_of: BFO:0000050 UBERON:0002370 ! part of thymus intersection_of: RO:0002215 GO:0043277 ! capable of apoptotic cell clearance relationship: BFO:0000050 UBERON:0002370 ! part of thymus relationship: RO:0002215 GO:0043277 ! capable of apoptotic cell clearance property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0000867 name: secondary lymphoid organ macrophage def: "A tissue-resident macrophage found in a secondary lymphoid organ." [GO_REF:0000031, GOC:ana, GOC:tfm] subset: cellxgene_subset subset: human_subset subset: mouse_subset is_a: CL:0000864 ! tissue-resident macrophage [Term] id: CL:0000868 name: lymph node macrophage def: "A secondary lymphoid organ macrophage found in a lymph node. This cell is CD169-high." [GO_REF:0000031, GOC:ana, GOC:tfm, PMID:11971865] comment: Marker was observed on rat cells. subset: human_subset subset: mouse_subset synonym: "MF.LN" EXACT [] is_a: CL:0000867 {is_inferred="true"} ! secondary lymphoid organ macrophage intersection_of: CL:0000867 ! secondary lymphoid organ macrophage intersection_of: BFO:0000050 UBERON:0000029 ! part of lymph node intersection_of: RO:0015015 PR:000001931 ! has high plasma membrane amount sialoadhesin intersection_of: RO:0015016 PR:000001012 ! has low plasma membrane amount integrin alpha-M intersection_of: RO:0015016 PR:000001813 ! has low plasma membrane amount adhesion G protein-coupled receptor E1 relationship: BFO:0000050 UBERON:0000029 ! part of lymph node relationship: RO:0015015 PR:000001931 ! has high plasma membrane amount sialoadhesin relationship: RO:0015016 PR:000001012 ! has low plasma membrane amount integrin alpha-M relationship: RO:0015016 PR:000001813 ! has low plasma membrane amount adhesion G protein-coupled receptor E1 [Term] id: CL:0000869 name: tonsillar macrophage def: "A gut-associated lymphoid tissue macrophage found in tonsils." [GO_REF:0000031, GOC:ana, PMID:16048540] subset: human_subset subset: mouse_subset is_a: CL:0000885 ! gut-associated lymphoid tissue macrophage intersection_of: CL:0000884 ! mucosa-associated lymphoid tissue macrophage intersection_of: BFO:0000050 UBERON:0002372 ! part of tonsil intersection_of: RO:0002215 GO:0002395 ! capable of immune response in nasopharyngeal-associated lymphoid tissue relationship: BFO:0000050 UBERON:0002372 ! part of tonsil relationship: RO:0002215 GO:0002395 ! capable of immune response in nasopharyngeal-associated lymphoid tissue [Term] id: CL:0000870 name: Peyer's patch macrophage def: "A gut-associated lymphoid tissue macrophage found in the Peyer's patches." [GO_REF:0000031, GOC:ana, GOC:tfm] subset: human_subset subset: mouse_subset is_a: CL:0000885 {is_inferred="true"} ! gut-associated lymphoid tissue macrophage intersection_of: CL:0000885 ! gut-associated lymphoid tissue macrophage intersection_of: BFO:0000050 UBERON:0001211 ! part of Peyer's patch relationship: BFO:0000050 UBERON:0001211 ! part of Peyer's patch [Term] id: CL:0000871 name: splenic macrophage def: "A secondary lymphoid organ macrophage found in the spleen." [GO_REF:0000031, PMID:15771589, PMID:16322748] comment: Role or process: immune, clearance of apoptotic and senescent cells. subset: human_subset subset: mouse_subset xref: FMA:83026 is_a: CL:0000867 {is_inferred="true"} ! secondary lymphoid organ macrophage is_a: CL:2000074 ! splenocyte intersection_of: CL:0000867 ! secondary lymphoid organ macrophage intersection_of: BFO:0000050 UBERON:0002106 ! part of spleen intersection_of: RO:0002215 GO:0034102 ! capable of erythrocyte clearance relationship: RO:0002215 GO:0034102 ! capable of erythrocyte clearance [Term] id: CL:0000872 name: splenic marginal zone macrophage def: "A splenic macrophage found in the marginal zone of the spleen, involved in recognition and clearance of particulate material from the splenic circulation. Markers include F4/80-negative, MARCO-positive, SR-A-positive, SIGN-R1-positive, and Dectin2-positive." [GO_REF:0000031, GOC:ana, PMID:16861066] comment: Markers: Mouse: F4/80-, MARCO+, SR-A+, SIGN-R1+, Dectin2+. subset: human_reference_atlas subset: human_subset subset: mouse_subset is_a: CL:0000871 {is_inferred="true"} ! splenic macrophage intersection_of: CL:0000871 ! splenic macrophage intersection_of: BFO:0000050 UBERON:0001251 ! part of marginal zone of spleen intersection_of: CL:4030046 PR:000001012 ! lacks_plasma_membrane_part integrin alpha-M intersection_of: RO:0002104 PR:000001806 ! has plasma membrane part C-type lectin domain family 6 member A intersection_of: RO:0002104 PR:000001884 ! has plasma membrane part macrophage receptor MARCO intersection_of: RO:0002104 PR:000001885 ! has plasma membrane part macrophage scavenger receptor types I and II intersection_of: RO:0002104 PR:000006172 ! has plasma membrane part CD209 molecule-like protein B relationship: BFO:0000050 UBERON:0001251 ! part of marginal zone of spleen relationship: CL:4030046 PR:000001012 ! lacks_plasma_membrane_part integrin alpha-M relationship: RO:0002104 PR:000001806 ! has plasma membrane part C-type lectin domain family 6 member A relationship: RO:0002104 PR:000001884 ! has plasma membrane part macrophage receptor MARCO relationship: RO:0002104 PR:000001885 ! has plasma membrane part macrophage scavenger receptor types I and II relationship: RO:0002104 PR:000006172 ! has plasma membrane part CD209 molecule-like protein B property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/2d-ftu/spleen-red-pulp/v1.2/assets/2d-ftu-spleen-red-pulp.png" xsd:string {terms:licence="http://creativecommons.org/licenses/by/4.0/", xref="doi:10.48539/HBM355.ZFMS.256"} property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0000873 name: splenic metallophillic macrophage def: "A splenic macrophage found in the areas surrounding the white pulp of the spleen, adjacent to the marginal sinus. Markers include F4/80-negative, Dectin2-low, sialoadhesin-positive." [GO_REF:0000031, GOC:ana, PMID:20018690] comment: Markers: Mouse: F4/80-, Dectin2-low, sialoadhesin+. subset: human_subset subset: mouse_subset is_a: CL:0000871 {is_inferred="true"} ! splenic macrophage intersection_of: CL:0000871 ! splenic macrophage intersection_of: BFO:0000050 UBERON:0001251 ! part of marginal zone of spleen intersection_of: CL:4030046 PR:000001813 ! lacks_plasma_membrane_part adhesion G protein-coupled receptor E1 intersection_of: RO:0002104 PR:000001931 ! has plasma membrane part sialoadhesin intersection_of: RO:0002220 UBERON:0001959 ! adjacent to white pulp of spleen intersection_of: RO:0015016 PR:000001806 ! has low plasma membrane amount C-type lectin domain family 6 member A relationship: BFO:0000050 UBERON:0001251 ! part of marginal zone of spleen relationship: CL:4030046 PR:000001813 ! lacks_plasma_membrane_part adhesion G protein-coupled receptor E1 relationship: RO:0002104 PR:000001931 ! has plasma membrane part sialoadhesin relationship: RO:0002220 UBERON:0001959 ! adjacent to white pulp of spleen relationship: RO:0015016 PR:000001806 ! has low plasma membrane amount C-type lectin domain family 6 member A [Term] id: CL:0000874 name: splenic red pulp macrophage def: "A splenic macrophage found in the red-pulp of the spleen, and involved in immune responses to blood-borne pathogens and in the clearance of senescent erythrocytes. Markers include F4/80-positive, CD68-positive, MR-positive, Dectin2-positive, macrosialin-positive, and sialoadhesin-low." [GO_REF:0000031, GOC:ana, PMID:19644016] comment: Markers: Mouse: F4/80+, CD68+, MR+, Dectin2+, macrosialin+, sialoadhesin-low; role or process: immune, clearance of senescent erythrocytes. subset: human_reference_atlas subset: human_subset subset: mouse_subset is_a: CL:0000871 {is_inferred="true"} ! splenic macrophage intersection_of: CL:0000871 ! splenic macrophage intersection_of: BFO:0000050 UBERON:0001250 ! part of red pulp of spleen intersection_of: CL:4030046 PR:000001013 ! lacks_plasma_membrane_part integrin alpha-X intersection_of: RO:0002104 PR:000001806 ! has plasma membrane part C-type lectin domain family 6 member A intersection_of: RO:0002104 PR:000001813 ! has plasma membrane part adhesion G protein-coupled receptor E1 intersection_of: RO:0002104 PR:000002064 ! has plasma membrane part macrosialin intersection_of: RO:0002104 PR:000002972 ! has plasma membrane part macrophage mannose receptor 1 intersection_of: RO:0002215 GO:0006955 ! capable of immune response intersection_of: RO:0002215 GO:0034102 ! capable of erythrocyte clearance intersection_of: RO:0015016 PR:000001012 ! has low plasma membrane amount integrin alpha-M intersection_of: RO:0015016 PR:000001931 ! has low plasma membrane amount sialoadhesin relationship: BFO:0000050 UBERON:0001250 ! part of red pulp of spleen relationship: CL:4030046 PR:000001013 ! lacks_plasma_membrane_part integrin alpha-X relationship: RO:0002104 PR:000001806 ! has plasma membrane part C-type lectin domain family 6 member A relationship: RO:0002104 PR:000001813 ! has plasma membrane part adhesion G protein-coupled receptor E1 relationship: RO:0002104 PR:000002064 ! has plasma membrane part macrosialin relationship: RO:0002104 PR:000002972 ! has plasma membrane part macrophage mannose receptor 1 relationship: RO:0002215 GO:0006955 ! capable of immune response relationship: RO:0015016 PR:000001012 ! has low plasma membrane amount integrin alpha-M relationship: RO:0015016 PR:000001931 ! has low plasma membrane amount sialoadhesin property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/2d-ftu/spleen-red-pulp/v1.2/assets/2d-ftu-spleen-red-pulp.png" xsd:string {terms:licence="http://creativecommons.org/licenses/by/4.0/", xref="doi:10.48539/HBM355.ZFMS.256"} property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0000875 name: non-classical monocyte def: "A type of monocyte characterized by low expression of CCR2, low responsiveness to monocyte chemoattractant CCL2/MCP1, low phagocytic activity, and decrease size relative to classical monocytes, but increased co-stimulatory activity. May also play a role in tissue repair." [GO_REF:0000031, GOC:add, PMID:16322748, PMID:18303997, PMID:20628149, PMID:20870168] comment: Markers: CCR2-CX3CCR1+ (human, mouse, rat); human: CD16+, CCR5+, CD32/FcgRII-high, MHCII+, CD86+; mouse: CD62L-Ly6C-. subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "patrolling monocyte" EXACT [] synonym: "resident monocyte" EXACT [] is_a: CL:0000576 {is_inferred="true"} ! monocyte intersection_of: CL:0000576 ! monocyte intersection_of: CL:4030046 PR:000001002 ! lacks_plasma_membrane_part CD19 molecule intersection_of: CL:4030046 PR:000001020 ! lacks_plasma_membrane_part CD3 epsilon intersection_of: CL:4030046 PR:000001289 ! lacks_plasma_membrane_part membrane-spanning 4-domains subfamily A member 1 intersection_of: RO:0000053 PATO:0000587 ! has characteristic decreased size intersection_of: RO:0002215 GO:0031294 ! capable of lymphocyte costimulation intersection_of: RO:0002353 GO:0030224 ! output of monocyte differentiation intersection_of: RO:0015015 PR:000001206 ! has high plasma membrane amount CX3C chemokine receptor 1 relationship: CL:4030046 PR:000001002 ! lacks_plasma_membrane_part CD19 molecule relationship: CL:4030046 PR:000001020 ! lacks_plasma_membrane_part CD3 epsilon relationship: CL:4030046 PR:000001289 ! lacks_plasma_membrane_part membrane-spanning 4-domains subfamily A member 1 relationship: RO:0000053 PATO:0000587 ! has characteristic decreased size relationship: RO:0002202 CL:0002393 ! develops from intermediate monocyte relationship: RO:0002215 GO:0031294 ! capable of lymphocyte costimulation relationship: RO:0002353 GO:0030224 ! output of monocyte differentiation relationship: RO:0015015 PR:000001206 ! has high plasma membrane amount CX3C chemokine receptor 1 property_value: RO:0002175 NCBITaxon:9606 property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0000875" xsd:string {name="non-classical monocyte on CELLxGENE CellGuide"} property_value: terms:description "Non-classical monocytes, also known as patrolling monocytes, are a subtype of monocytes in the circulation, accounting for approximately 5-10% of total human monocytes. These monocytes are characterized by the differential expression of two surface markers, CD14 and CD16, with non-classical monocytes expressing CD14 and high levels of CD16 (CD14+ CD16++). Classical monocytes are released from the bone marrow into the circulation and can transition to intermediate followed by non-classical monocytes.\nNon-classical monocytes patrol the endothelium and, upon sensing inflammation or injury, migrate across it. Non-classical monocytes are also involved in the removal of damaged cells via phagocytosis. This process enables the cells to engulf and destroy pathogens, debris, and apoptotic cells. During homeostasis, these monocytes appear to have an important function in maintaining vascular integrity.\nNon-classical monocytes are also able to induce CD4+ T cell proliferation and sense viruses. They can produce and secrete a wide range of inflammatory cytokines and chemokines to reinforce and shape the immune response. Non-classical monocytes also appear to play a role in different inflammatory diseases states including atherosclerosis, multiple sclerosis, and rheumatoid arthritis.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1016/j.immuni.2018.10.005", xref="DOI:10.1111/sji.12883", xref="DOI:10.1146/annurev-immunol-042617-053119"} [Term] id: CL:0000876 name: splenic white pulp macrophage def: "A splenic macrophage found in the white pulp of the spleen. Markers include F4/80-negative, CD68-positive, and macrosialin-positive." [GO_REF:0000031, GOC:ana, PMID:11207597] comment: Markers: Mouse: F4/80-, CD68+, macrosialin+. subset: human_reference_atlas subset: human_subset subset: mouse_subset is_a: CL:0000871 {is_inferred="true"} ! splenic macrophage intersection_of: CL:0000871 ! splenic macrophage intersection_of: BFO:0000050 UBERON:0001959 ! part of white pulp of spleen intersection_of: CL:4030046 PR:000001813 ! lacks_plasma_membrane_part adhesion G protein-coupled receptor E1 intersection_of: RO:0002104 PR:000002064 ! has plasma membrane part macrosialin relationship: BFO:0000050 UBERON:0001959 ! part of white pulp of spleen relationship: CL:4030046 PR:000001813 ! lacks_plasma_membrane_part adhesion G protein-coupled receptor E1 relationship: RO:0002104 PR:000002064 ! has plasma membrane part macrosialin property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/2d-ftu/spleen-white-pulp/v1.2/assets/2d-ftu-spleen-white-pulp.png" xsd:string {terms:licence="http://creativecommons.org/licenses/by/4.0/", xref="doi:10.48539/HBM559.FNBB.6273"} property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0000877 name: splenic tingible body macrophage def: "A splenic white pulp macrophage found in and around the germinal centers of the white pulp of the spleen that participates in phagocytosis of apoptotic B cells from the germinal centers. A marker for a cell of this type is Mertk-positive." [GO_REF:0000031, GOC:ana, GOC:tfm, PMID:19631584] subset: human_reference_atlas subset: human_subset subset: mouse_subset is_a: CL:0000876 {is_inferred="true"} ! splenic white pulp macrophage intersection_of: CL:0000876 ! splenic white pulp macrophage intersection_of: BFO:0000050 UBERON:0001249 ! part of spleen lymphoid follicle intersection_of: RO:0002104 PR:000010329 ! has plasma membrane part tyrosine-protein kinase Mer intersection_of: RO:0002215 GO:0043277 ! capable of apoptotic cell clearance relationship: BFO:0000050 UBERON:0001249 ! part of spleen lymphoid follicle relationship: RO:0002104 PR:000010329 ! has plasma membrane part tyrosine-protein kinase Mer relationship: RO:0002215 GO:0043277 ! capable of apoptotic cell clearance property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/2d-ftu/spleen-red-pulp/v1.2/assets/2d-ftu-spleen-red-pulp.png" xsd:string {terms:licence="http://creativecommons.org/licenses/by/4.0/", xref="doi:10.48539/HBM355.ZFMS.256"} property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0000878 name: central nervous system macrophage def: "A tissue-resident macrophage found in the central nervous system." [GO_REF:0000031, PMID:16322748] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "CNS macrophage" EXACT [] is_a: CL:0000864 {is_inferred="true"} ! tissue-resident macrophage is_a: CL:0002319 ! neural cell intersection_of: CL:0000864 ! tissue-resident macrophage intersection_of: BFO:0000050 UBERON:0001017 ! part of central nervous system relationship: BFO:0000050 UBERON:0001017 ! part of central nervous system property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0000878" xsd:string {name="central nervous system macrophage on CELLxGENE CellGuide"} property_value: terms:description "Central Nervous System (CNS) macrophages represent an integral part of the brain's innate immune system. These immune cells play crucial roles in maintenance and regulation, homeostasis, and disease response, thereby helping in the overall cognitive functioning of an organism. \nThere are different macrophage populations in the CNS, often classified into microglial cells, which reside in the parenchyma, and non-parenchymal macrophages at the interface between the brain and the periphery, including the perivascular spaces, the choroid plexus, and the meninges. CNS macrophages are derived from erythromyeloid progenitors in the yolk sac. CNS macrophages have distinct morphologies: Meningeal and perivascular macrophages have a more elongated shape than microglia, which are characterized by a small cell body with fine processes; in contrast, choroid plexus macrophages typically have a stellate shape.\nMicroglia are the most abundant abundant mononuclear phagocytes and have been shown to play a number of physiological roles, including proinflammatory and anti-inflammatory functions, synaptic pruning and remodeling, and apoptotic cell removal through phagocytosis. Non-parenchymal CAMs primarily support the barrier function against external antigens. Meningeal macrophages have been shown to respond to peripheral microbial challenges and to protect the brain against fatal viral infection.\nCNS macrophages are also involved in the initiation and progression of many neurological diseases, such as Alzheimer's disease and Parkinson's disease as well as multiple sclerosis.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1007/s00281-013-0382-8", xref="DOI:10.1016/j.immuni.2022.10.005", xref="DOI:10.1016/j.tins.2021.07.002", xref="DOI:10.1038/s41583-019-0201-x"} [Term] id: CL:0000879 name: meningeal macrophage def: "A border associated macrophage that is part of a meninx. This macrophage type is elongated and amoeboid spindle-shaped with limited mobility. This macrophage is highly phagocytic, expresses scavenger receptors, has dynamic protrusions and extends its processes during inflammation." [GO_REF:0000031, GOC:ana, PMID:11591794, PMID:24078900, PMID:37232741] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "MM" RELATED OMO:0003000 [PMID:33556248] synonym: "MnMΦ" RELATED OMO:0003000 [PMID:38347231] synonym: "sdΜΦ" RELATED OMO:0003000 [PMID:37232741] synonym: "subdural leptomeningeal macrophage" EXACT [PMID:33556248] synonym: "subdural meningeal macrophage" EXACT [PMID:28323268] is_a: CL:4042003 ! border associated macrophage intersection_of: CL:4042003 ! border associated macrophage intersection_of: BFO:0000050 UBERON:0002360 ! part of meninx intersection_of: RO:0002215 GO:0005044 ! capable of scavenger receptor activity relationship: BFO:0000050 UBERON:0002360 ! part of meninx relationship: RO:0002215 GO:0005044 ! capable of scavenger receptor activity [Term] id: CL:0000880 name: choroid plexus macrophage def: "A border associated macrophage found at the interface between the blood and the cerebrospinal fluid in the brain. This central nervous system macrophage has a star-like shaped body and expresses scavenger receptors." [GO_REF:0000031, GOC:ana, PMID:37232741, PMID:9550136] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "cpMΦ" RELATED OMO:0003000 [PMID:37232741] is_a: CL:4042003 ! border associated macrophage intersection_of: CL:4042003 ! border associated macrophage intersection_of: BFO:0000050 UBERON:0001886 ! part of choroid plexus intersection_of: RO:0002215 GO:0005044 ! capable of scavenger receptor activity relationship: BFO:0000050 UBERON:0001886 ! part of choroid plexus relationship: RO:0002215 GO:0005044 ! capable of scavenger receptor activity [Term] id: CL:0000881 name: perivascular macrophage def: "A border associated macrophage that is adjacent to a small blood vessel of a brain. A perivascular macrophage expresses the markers CD14, CD16 and CD163. In homeostatic conditions, this central nervous system macrophage has a non-motile cell body with extending and retracting projections through the blood vessel wall." [GO_REF:0000031, GOC:tfm, PMID:16507898, PMID:37232741] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "pvMΦ" RELATED OMO:0003000 [PMID:37232741] is_a: CL:4033054 ! perivascular cell is_a: CL:4042003 {is_inferred="true"} ! border associated macrophage intersection_of: CL:4042003 ! border associated macrophage intersection_of: BFO:0000050 UBERON:0001981 ! part of blood vessel intersection_of: RO:0002104 PR:000001483 ! has plasma membrane part low affinity immunoglobulin gamma Fc region receptor III intersection_of: RO:0002104 PR:000001889 ! has plasma membrane part CD14 molecule intersection_of: RO:0002104 PR:000001925 ! has plasma membrane part scavenger receptor cysteine-rich type 1 protein M130 relationship: BFO:0000050 UBERON:0001981 ! part of blood vessel relationship: RO:0002104 PR:000001483 ! has plasma membrane part low affinity immunoglobulin gamma Fc region receptor III relationship: RO:0002104 PR:000001889 ! has plasma membrane part CD14 molecule relationship: RO:0002104 PR:000001925 ! has plasma membrane part scavenger receptor cysteine-rich type 1 protein M130 [Term] id: CL:0000882 name: thymic medullary macrophage def: "A thymic macrophage found in the thymic medulla." [GO_REF:0000031, GOC:ana, PMID:9048205] subset: human_reference_atlas subset: human_subset subset: mouse_subset is_a: CL:0000866 {is_inferred="true"} ! thymic macrophage intersection_of: CL:0000866 ! thymic macrophage intersection_of: BFO:0000050 UBERON:0002124 ! part of medulla of thymus relationship: BFO:0000050 UBERON:0002124 ! part of medulla of thymus property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/2d-ftu/thymus-thymus-lobule/v1.3/assets/2d-ftu-thymus-thymus-lobule.png" xsd:string {terms:licence="http://creativecommons.org/licenses/by/4.0/", xref="doi:10.48539/HBM322.LZLG.752"} property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0000883 name: thymic cortical macrophage def: "A thymic macrophage found in the thymic cortex." [GO_REF:0000031, GOC:ana, GOC:tfm, PMID:9048205] subset: human_reference_atlas subset: human_subset subset: mouse_subset is_a: CL:0000866 {is_inferred="true"} ! thymic macrophage intersection_of: CL:0000866 ! thymic macrophage intersection_of: BFO:0000050 UBERON:0002123 ! part of cortex of thymus relationship: BFO:0000050 UBERON:0002123 ! part of cortex of thymus property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/2d-ftu/thymus-thymus-lobule/v1.3/assets/2d-ftu-thymus-thymus-lobule.png" xsd:string {terms:licence="http://creativecommons.org/licenses/by/4.0/", xref="doi:10.48539/HBM322.LZLG.752"} property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0000884 name: mucosa-associated lymphoid tissue macrophage def: "A tissue-resident macrophage found in the mucosa associated lymphoid tissue." [GO_REF:0000031, GOC:ana, GOC:tfm, PMID:19906191] subset: cellxgene_subset subset: human_subset subset: mouse_subset is_a: CL:0000867 {is_inferred="true"} ! secondary lymphoid organ macrophage intersection_of: CL:0000867 ! secondary lymphoid organ macrophage intersection_of: BFO:0000050 UBERON:0001961 ! part of mucosa-associated lymphoid tissue relationship: BFO:0000050 UBERON:0001961 ! part of mucosa-associated lymphoid tissue [Term] id: CL:0000885 name: gut-associated lymphoid tissue macrophage def: "A mucosa-associated lymphoid tissue macrophage found in the mucosa-associated lymphoid tissues of the gut." [GO_REF:0000031, GOC:ana, PMID:19906191] subset: human_subset subset: mouse_subset is_a: CL:0000884 {is_inferred="true"} ! mucosa-associated lymphoid tissue macrophage intersection_of: CL:0000884 ! mucosa-associated lymphoid tissue macrophage intersection_of: BFO:0000050 UBERON:0001962 ! part of gut-associated lymphoid tissue intersection_of: RO:0002215 GO:0002387 ! capable of immune response in gut-associated lymphoid tissue relationship: BFO:0000050 UBERON:0001962 ! part of gut-associated lymphoid tissue relationship: RO:0002215 GO:0002387 ! capable of immune response in gut-associated lymphoid tissue [Term] id: CL:0000886 name: nasal and broncial associated lymphoid tissue macrophage def: "A mucosa-associated lymphoid tissue macrophage found in the nasal and bronchial mucosa-associated lymphoid tissues." [GO_REF:0000031, GOC:ana, PMID:16048540] subset: human_subset subset: mouse_subset is_a: CL:0000884 {is_inferred="true"} ! mucosa-associated lymphoid tissue macrophage intersection_of: CL:0000884 ! mucosa-associated lymphoid tissue macrophage intersection_of: BFO:0000050 UBERON:0001963 ! part of bronchial-associated lymphoid tissue intersection_of: RO:0002215 GO:0002395 ! capable of immune response in nasopharyngeal-associated lymphoid tissue relationship: BFO:0000050 UBERON:0001963 ! part of bronchial-associated lymphoid tissue relationship: RO:0002215 GO:0002395 ! capable of immune response in nasopharyngeal-associated lymphoid tissue [Term] id: CL:0000887 name: lymph node subcapsular sinus macrophage def: "A lymph node macrophage found in the subcapsular sinus of lymph nodes that participates in sensing, clearance, and antigen presentation of lymph-borne particulate antigens. This macrophage is capable of activating invaraint NKT cells and is CD169-positive." [GO_REF:0000031, GOC:tfm, PMID:14668803, PMID:17934446, PMID:20228797] subset: human_reference_atlas subset: human_subset subset: mouse_subset is_a: CL:0000868 {is_inferred="true"} ! lymph node macrophage intersection_of: CL:0000868 ! lymph node macrophage intersection_of: RO:0002104 PR:000001931 ! has plasma membrane part sialoadhesin intersection_of: RO:0002215 GO:0032816 ! capable of positive regulation of natural killer cell activation intersection_of: RO:0002220 UBERON:0002194 ! adjacent to capsule of lymph node relationship: RO:0002215 GO:0032816 ! capable of positive regulation of natural killer cell activation relationship: RO:0002220 UBERON:0002194 ! adjacent to capsule of lymph node property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0000888 name: lymph node tingible body macrophage def: "A lymph node macrophage found in the cortex of lymph nodes, in particular in and around the germinal centers, and that participates in phagocytosis of apoptotic B cells from the germinal centers." [GO_REF:0000031, GOC:ana, GOC:tfm, PMID:19631584] subset: human_reference_atlas subset: human_subset subset: mouse_subset is_a: CL:0000868 {is_inferred="true"} ! lymph node macrophage intersection_of: CL:0000868 ! lymph node macrophage intersection_of: BFO:0000050 UBERON:0002006 ! part of cortex of lymph node intersection_of: RO:0002215 GO:0002905 ! capable of regulation of mature B cell apoptotic process intersection_of: RO:0002215 GO:0043277 ! capable of apoptotic cell clearance relationship: BFO:0000050 UBERON:0002006 ! part of cortex of lymph node relationship: RO:0002215 GO:0002905 ! capable of regulation of mature B cell apoptotic process relationship: RO:0002215 GO:0043277 ! capable of apoptotic cell clearance property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0000889 name: myeloid suppressor cell def: "An immature myeloid leukocyte of heterogeneous phenotype found particularly in cancer and sepsis patients that is capable of suppressing activity of T cells in ex vivo assays. This cell type is CD45-positive, CD11b-positive." [GO_REF:0000031, GOC:add, GOC:ana, PMID:16168663, PMID:17016554, PMID:17016559] comment: Markers: Mouse: CD11b+GR1+CD31+; Human: CD34+ CD33+CD15-CD13+. (According to some reports in humans these cells are iNOS+ARG1+IL13+IFNg+); location: In cancerous tissue; in the blood and lymphoid organs in sepsis. subset: blood_and_immune_upper_slim subset: cellxgene_subset subset: human_subset subset: mouse_subset is_a: CL:0000766 {is_inferred="true"} ! myeloid leukocyte intersection_of: CL:0000766 ! myeloid leukocyte intersection_of: RO:0000053 PATO:0001501 ! has characteristic immature intersection_of: RO:0002104 PR:000001006 ! has plasma membrane part receptor-type tyrosine-protein phosphatase C intersection_of: RO:0002104 PR:000001012 ! has plasma membrane part integrin alpha-M intersection_of: RO:0002215 GO:0050777 ! capable of negative regulation of immune response relationship: RO:0000053 PATO:0001501 ! has characteristic immature relationship: RO:0002104 PR:000001006 ! has plasma membrane part receptor-type tyrosine-protein phosphatase C relationship: RO:0002104 PR:000001012 ! has plasma membrane part integrin alpha-M relationship: RO:0002215 GO:0050777 ! capable of negative regulation of immune response [Term] id: CL:0000890 name: M2 macrophage def: "An elicited macrophage characterized by low production of pro-inflammatory and Th1 polarizing cytokines and high expression of arginase-1, and associated with tissue remodelling." [GO_REF:0000031, GOC:ana, GOC:tfm, PMID:20510870] comment: Role or process: tissue remodeling. subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "alternatively activated macrophage" EXACT [PMID:30861466] synonym: "anti-inflammatory macrophage" RELATED [] is_a: CL:0000861 {is_inferred="true"} ! elicited macrophage intersection_of: CL:0000861 ! elicited macrophage intersection_of: BFO:0000051 PR:000001844 ! has part arginase-1 intersection_of: RO:0002215 GO:0048771 ! capable of tissue remodeling relationship: BFO:0000051 PR:000001844 ! has part arginase-1 relationship: RO:0002202 CL:0020017 ! develops from M0 macrophage relationship: RO:0002215 GO:0048771 ! capable of tissue remodeling property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0000890" xsd:string {name="M2 macrophage on CELLxGENE CellGuide"} property_value: terms:description "Alternatively activated macrophages, also referred to as M2 macrophages, are immune cells originating from monocytes. The M1/M2 classification is based upon macrophage polarization rather than macrophage location and refers to macrophage activation towards either a more inflammatory or more resolving phenotype, respectively, although the functional diversity of macrophages is more nuanced than such a dichotomy suggests.\nM2 macrophages cells are differentiated from their precursors generally in response to Th2 cytokines, such as interleukin-4 (IL-4), interleukin-10 (IL-10), and interleukin-13 (IL-13). Tissue-resident macrophages are also sometimes said to have an “M2-like” phenotype. M2 macrophages play key roles in immunoregulation and disease resolution.\nFunctionally, alternatively activated macrophages are essential in wound healing and tissue repair and remodeling, largely due to their potent anti-inflammatory actions and their ability to promote angiogenesis. They achieve these functions by the production of specific growth factors and signaling proteins including Arg1, Ym1/2, Fizz1, and TGF-β. Additionally, they provide defense against specific categories of pathogens, particularly parasites, through specific communication with Th2 cells. \nHowever, dysfunction of M2 macrophages can be harmful. Alternatively activated macrophages have been associated with several pathological conditions such as asthma, fibrosis, and tumor progression. This is due to their capacity to inhibit inflammatory responses, promote unneeded wound healing processes, and support tumour growth and spreading. Furthermore, complex roles have been observed in metabolic disorders, cardiovascular diseases, and neurodegenerative diseases, showing the diverse functional spectrum of these cells.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1038/s41392-023-01452-1", xref="DOI:10.1186/s12935-021-02089-2", xref="DOI:10.3389/fimmu.2015.00263", xref="DOI:10.3389/fimmu.2020.583084"} [Term] id: CL:0000891 name: foam cell def: "A type of cell containing lipids in small vacuoles and typically seen in atherolosclerotic lesions, as well as other conditions." [GOC:add] subset: human_subset subset: mouse_subset xref: BTO:0003872 xref: FMA:83586 xref: MESH:D005487 is_a: CL:0000000 ! cell [Term] id: CL:0000892 name: smooth muscle cell derived foam cell def: "A type of foam cell derived from a smooth muscle cell containing lipids in small vacuoles and typically seen in atherolosclerotic lesions, as well as other conditions." [GOC:add, PMID:30664015] subset: human_subset subset: mouse_subset is_a: BFO:0000002 is_a: CL:0000255 ! eukaryotic cell is_a: CL:0000891 ! foam cell relationship: RO:0002202 CL:0000192 ! develops from smooth muscle cell [Term] id: CL:0000893 name: thymocyte def: "An immature T cell located in the thymus." [GO_REF:0000031, GOC:add, GOC:tfm, PMID:12415312] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "immature T cell" BROAD [] synonym: "immature T lymphocyte" BROAD [] synonym: "immature T-cell" BROAD [] synonym: "immature T-lymphocyte" BROAD [] synonym: "thymic lymphocyte" EXACT [] xref: BTO:0001372 xref: CALOHA:TS-1042 xref: FMA:72202 xref: MESH:D060168 xref: XAO:0003159 is_a: CL:0002420 {is_inferred="true"} ! immature T cell intersection_of: CL:0000084 ! T cell intersection_of: BFO:0000050 UBERON:0002370 ! part of thymus intersection_of: CL:4030044 GO:0045058 ! has_not_completed T cell selection relationship: BFO:0000050 UBERON:0002370 ! part of thymus [Term] id: CL:0000894 name: DN1 thymic pro-T cell def: "A pro-T cell that has the phenotype CD4-negative, CD8-negative, CD44-positive, and CD25-negative." [GO_REF:0000031, GOC:add, GOC:tfm] subset: human_subset subset: mouse_subset synonym: "DN1 thymic pro-T lymphocyte" EXACT [] synonym: "DN1 thymic pro-T-cell" EXACT [] synonym: "DN1 thymic pro-T-lymphocyte" EXACT [] synonym: "DN1 thymic progenitor T cell" EXACT [] synonym: "DN1 thymocyte" EXACT [] synonym: "double negative 1" EXACT [] synonym: "preT.DN1.Th" EXACT [] is_a: CL:0000827 {is_inferred="true"} ! pro-T cell intersection_of: CL:0000827 ! pro-T cell intersection_of: BFO:0000050 UBERON:0002370 ! part of thymus intersection_of: CL:4030046 PR:000001004 ! lacks_plasma_membrane_part CD4 molecule intersection_of: CL:4030046 PR:000001084 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD8 alpha chain intersection_of: CL:4030046 PR:000001380 ! lacks_plasma_membrane_part interleukin-2 receptor subunit alpha intersection_of: RO:0002104 PR:000001307 ! has plasma membrane part CD44 molecule relationship: BFO:0000050 UBERON:0002370 ! part of thymus relationship: CL:4030046 PR:000001004 ! lacks_plasma_membrane_part CD4 molecule relationship: CL:4030046 PR:000001084 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD8 alpha chain relationship: CL:4030046 PR:000001380 ! lacks_plasma_membrane_part interleukin-2 receptor subunit alpha relationship: RO:0002104 PR:000001307 ! has plasma membrane part CD44 molecule relationship: RO:0002202 CL:0002425 ! develops from early T lineage precursor [Term] id: CL:0000895 name: naive thymus-derived CD4-positive, alpha-beta T cell def: "An antigen inexperienced CD4-positive, alpha-beta T cell with the phenotype CCR7-positive, CD127-positive and CD62L-positive. This cell type develops in the thymus. This cell type is also described as being CD25-negative, CD62L-high, and CD44-low." [GO_REF:0000031, GOC:add, GOC:tfm, http://www.immgen.org/index_content.html, PMID:19100699, PMID:22343568] comment: These cells have not been exposed to antigen following thymic T-cell selection; found in blood and secondary lymphoid organs. This cell type is compatible with the HIPC Lyoplate markers for 'naive CD4+ T cell', but includes additional markers known to be expressed on naive CD4+ T cells. subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "naive CD4+ T cell" BROAD [PMID:22343568] synonym: "naive thymus-derived CD4-positive, alpha-beta T lymphocyte" EXACT [] synonym: "naive thymus-derived CD4-positive, alpha-beta T-cell" EXACT [] synonym: "naive thymus-derived CD4-positive, alpha-beta T-lymphocyte" EXACT [] synonym: "T.4Nve.Sp" EXACT [] synonym: "Th0" EXACT [GOC:tfm] is_a: CL:0000624 {is_inferred="true"} ! CD4-positive, alpha-beta T cell is_a: CL:0000898 ! naive T cell intersection_of: CL:0000624 ! CD4-positive, alpha-beta T cell intersection_of: CL:4030046 PR:000001380 ! lacks_plasma_membrane_part interleukin-2 receptor subunit alpha intersection_of: RO:0002104 PR:000001015 ! has plasma membrane part receptor-type tyrosine-protein phosphatase C isoform CD45RA intersection_of: RO:0002104 PR:000001203 ! has plasma membrane part C-C chemokine receptor type 7 intersection_of: RO:0002104 PR:000001869 ! has plasma membrane part interleukin-7 receptor subunit alpha intersection_of: RO:0015015 PR:000001318 ! has high plasma membrane amount L-selectin intersection_of: RO:0015016 PR:000001307 ! has low plasma membrane amount CD44 molecule relationship: CL:4030046 PR:000001380 ! lacks_plasma_membrane_part interleukin-2 receptor subunit alpha relationship: RO:0002202 CL:0002436 ! develops from mature CD4 single-positive thymocyte property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0000896 name: activated CD4-positive, alpha-beta T cell def: "A recently activated CD4-positive, alpha-beta T cell with the phenotype CD69-positive, CD62L-negative, CD127-negative, and CD25-positive." [GO_REF:0000031, GOC:add, GOC:pam] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "activated CD4-positive, alpha-beta T lymphocyte" EXACT [] synonym: "activated CD4-positive, alpha-beta T-cell" EXACT [] synonym: "activated CD4-positive, alpha-beta T-lymphocyte" EXACT [] is_a: CL:0000624 {is_inferred="true"} ! CD4-positive, alpha-beta T cell intersection_of: CL:0000624 ! CD4-positive, alpha-beta T cell intersection_of: CL:4030046 PR:000001318 ! lacks_plasma_membrane_part L-selectin intersection_of: CL:4030046 PR:000001869 ! lacks_plasma_membrane_part interleukin-7 receptor subunit alpha intersection_of: RO:0002104 PR:000001343 ! has plasma membrane part CD69 molecule intersection_of: RO:0002104 PR:000001380 ! has plasma membrane part interleukin-2 receptor subunit alpha relationship: CL:4030046 PR:000001318 ! lacks_plasma_membrane_part L-selectin relationship: CL:4030046 PR:000001869 ! lacks_plasma_membrane_part interleukin-7 receptor subunit alpha relationship: RO:0002104 PR:000001343 ! has plasma membrane part CD69 molecule relationship: RO:0002104 PR:000001380 ! has plasma membrane part interleukin-2 receptor subunit alpha relationship: RO:0002202 CL:0000895 ! develops from naive thymus-derived CD4-positive, alpha-beta T cell [Term] id: CL:0000897 name: CD4-positive, alpha-beta memory T cell def: "A CD4-positive, alpha-beta T cell that has differentiated into a memory T cell." [GOC:add, http://www.immgen.org/index_content.html, ISBN:0781735149] subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "CD4-positive, alpha-beta memory T lymphocyte" EXACT [] synonym: "CD4-positive, alpha-beta memory T-cell" EXACT [] synonym: "CD4-positive, alpha-beta memory T-lymphocyte" EXACT [] synonym: "T4.Mem.Sp" RELATED [] is_a: CL:0000624 ! CD4-positive, alpha-beta T cell is_a: CL:0000813 ! memory T cell intersection_of: CL:0000624 ! CD4-positive, alpha-beta T cell intersection_of: RO:0000053 PATO:0001603 ! has characteristic increased life span intersection_of: RO:0002353 GO:0002286 ! output of T cell activation involved in immune response intersection_of: RO:0002353 GO:0043379 ! output of memory T cell differentiation property_value: RO:0002175 NCBITaxon:9606 property_value: terms:contributor https://orcid.org/0000-0001-9990-8331 [Term] id: CL:0000898 name: naive T cell def: "Mature T cell not yet exposed to antigen with the phenotype CCR7-positive, CD45RA-positive, and CD127-positive. This cell type is also described as being CD25-negative, CD62L-high and CD44-low." [GO_REF:0000031, GOC:add, GOC:pam, GOC:tfm, PMID:19100699] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "naive T lymphocyte" EXACT [] synonym: "naive T-cell" EXACT [] synonym: "naive T-lymphocyte" EXACT [] is_a: CL:0002419 {is_inferred="true"} ! mature T cell intersection_of: CL:0002419 ! mature T cell intersection_of: RO:0002104 PR:000001015 ! has plasma membrane part receptor-type tyrosine-protein phosphatase C isoform CD45RA intersection_of: RO:0002104 PR:000001203 ! has plasma membrane part C-C chemokine receptor type 7 intersection_of: RO:0002104 PR:000001869 ! has plasma membrane part interleukin-7 receptor subunit alpha intersection_of: RO:0002353 GO:0045058 ! output of T cell selection intersection_of: RO:0015015 PR:000001318 ! has high plasma membrane amount L-selectin intersection_of: RO:0015016 PR:000001307 ! has low plasma membrane amount CD44 molecule relationship: RO:0002104 PR:000001015 ! has plasma membrane part receptor-type tyrosine-protein phosphatase C isoform CD45RA relationship: RO:0002104 PR:000001203 ! has plasma membrane part C-C chemokine receptor type 7 relationship: RO:0002104 PR:000001869 ! has plasma membrane part interleukin-7 receptor subunit alpha relationship: RO:0015015 PR:000001318 ! has high plasma membrane amount L-selectin relationship: RO:0015016 PR:000001307 ! has low plasma membrane amount CD44 molecule [Term] id: CL:0000899 name: T-helper 17 cell def: "CD4-positive, alpha-beta T cell with the phenotype RORgamma-t-positive, CXCR3-negative, CCR6-positive, and capable of producing IL-17." [GO_REF:0000031, GOC:add, GOC:pam, PMID:20303875, PMID:20969597, PMID:22343568] comment: This cell type is compatible with the HIPC Lyoplate markers for 'Th17 CD4+ T cell', but its logical definition includes additional known characteristics of T-helper 17 T cells. subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "helper T cell type 17" EXACT [] synonym: "IL-17-producing CD4+ T helper" EXACT [] synonym: "T helper cells type 17" EXACT [] synonym: "T(H)-17 cell" EXACT [] synonym: "Th17 CD4+ T cell" EXACT [PMID:22343568] synonym: "Th17 cell" EXACT [] synonym: "Th17 T cell" EXACT [] synonym: "Th17 T lymphocyte" EXACT [] synonym: "Th17 T-cell" EXACT [] synonym: "Th17 T-lymphocyte" EXACT [] xref: MESH:D058504 is_a: CL:0000492 {is_inferred="true"} ! CD4-positive helper T cell intersection_of: CL:0000492 ! CD4-positive helper T cell intersection_of: BFO:0000051 PR:000003455 ! has part nuclear receptor ROR-gamma isoform 2 intersection_of: CL:4030046 PR:000001207 ! lacks_plasma_membrane_part C-X-C chemokine receptor type 3 intersection_of: RO:0002104 PR:000001202 ! has plasma membrane part C-C chemokine receptor type 6 intersection_of: RO:0002215 GO:0032620 ! capable of interleukin-17 production relationship: BFO:0000051 PR:000003455 ! has part nuclear receptor ROR-gamma isoform 2 relationship: CL:4030046 PR:000001207 ! lacks_plasma_membrane_part C-X-C chemokine receptor type 3 relationship: RO:0002104 PR:000001202 ! has plasma membrane part C-C chemokine receptor type 6 relationship: RO:0002215 GO:0032620 ! capable of interleukin-17 production property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0000900 name: naive thymus-derived CD8-positive, alpha-beta T cell def: "A CD8-positive, alpha-beta T cell that has not experienced activation via antigen contact and has the phenotype CD45RA-positive, CCR7-positive and CD127-positive. This cell type is also described as being CD25-negative, CD62L-high and CD44-low." [GO_REF:0000031, GOC:add, GOC:tfm, http://www.immgen.org/index_content.html, ISBN:0781735149, PMID:22343568] comment: This cell traffics in secondary lymphoid organs and blood. This cell type is compatible with the HIPC Lyoplate markers for 'naive CD8+ T cell', but includes additional markers known to be expressed on naive CD8+ T cells. subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "naive CD8+ T cell" BROAD [PMID:22343568] synonym: "naive thymus-dervied CD8-positive, alpha-beta T lymphocyte" EXACT [] synonym: "naive thymus-dervied CD8-positive, alpha-beta T-cell" EXACT [] synonym: "naive thymus-dervied CD8-positive, alpha-beta T-lymphocyte" EXACT [] synonym: "T.8Nve.Sp" NARROW [] is_a: CL:0000625 {is_inferred="true"} ! CD8-positive, alpha-beta T cell is_a: CL:0000898 ! naive T cell intersection_of: CL:0000625 ! CD8-positive, alpha-beta T cell intersection_of: CL:4030046 PR:000001380 ! lacks_plasma_membrane_part interleukin-2 receptor subunit alpha intersection_of: RO:0002104 PR:000001015 ! has plasma membrane part receptor-type tyrosine-protein phosphatase C isoform CD45RA intersection_of: RO:0002104 PR:000001203 ! has plasma membrane part C-C chemokine receptor type 7 intersection_of: RO:0002104 PR:000001869 ! has plasma membrane part interleukin-7 receptor subunit alpha intersection_of: RO:0015015 PR:000001318 ! has high plasma membrane amount L-selectin intersection_of: RO:0015016 PR:000001307 ! has low plasma membrane amount CD44 molecule relationship: CL:4030046 PR:000001380 ! lacks_plasma_membrane_part interleukin-2 receptor subunit alpha relationship: RO:0002202 CL:0002437 ! develops from mature CD8 single-positive thymocyte property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0000901 name: Tr1 cell def: "CD4-positive alpha-beta T cell with regulatory function that produces IL-10." [GO_REF:0000031, GOC:add, GOC:pam, PMID:16903904] comment: These cells are reportedly induced by IL-10 and are capable of producing IFN-gamma, IL-5, IL-10, and TGF-beta.) subset: human_subset subset: mouse_subset synonym: "T-regulatory T cell type 1" EXACT [] synonym: "Tr1 T cell" EXACT [] synonym: "Tr1 T lymphocyte" EXACT [] synonym: "Tr1 T-cell" EXACT [] synonym: "Tr1 T-lymphocyte" EXACT [] is_a: CL:0000492 ! CD4-positive helper T cell is_a: CL:0000815 ! regulatory T cell intersection_of: CL:0000624 ! CD4-positive, alpha-beta T cell intersection_of: RO:0002215 GO:0032613 ! capable of interleukin-10 production intersection_of: RO:0002215 GO:0050777 ! capable of negative regulation of immune response relationship: RO:0002215 GO:0032613 ! capable of interleukin-10 production [Term] id: CL:0000902 name: induced T-regulatory cell def: "CD4-positive alpha-beta T cell with the phenotype CD25-positive, CTLA-4-positive, and FoxP3-positive with regulatory function." [GO_REF:0000031, GOC:add, GOC:pam, GOC:tfm, PMID:19464985] subset: human_subset subset: mouse_subset synonym: "adaptive Treg" RELATED [] synonym: "aTreg" RELATED [] synonym: "induced regulatory T cell" EXACT [] synonym: "induced regulatory T lymphocyte" EXACT [] synonym: "induced regulatory T-cell" EXACT [] synonym: "induced regulatory T-lymphocyte" EXACT [] synonym: "induced Treg" EXACT [] synonym: "iTreg" EXACT [] is_a: CL:0000792 {is_inferred="true"} ! CD4-positive, CD25-positive, alpha-beta regulatory T cell intersection_of: CL:0000792 ! CD4-positive, CD25-positive, alpha-beta regulatory T cell intersection_of: BFO:0000051 PR:000001350 ! has part forkhead box protein P3 intersection_of: RO:0002104 PR:000001852 ! has plasma membrane part cytotoxic T-lymphocyte protein 4 intersection_of: RO:0002202 CL:0000896 ! develops from activated CD4-positive, alpha-beta T cell relationship: BFO:0000051 PR:000001350 ! has part forkhead box protein P3 relationship: RO:0002104 PR:000001852 ! has plasma membrane part cytotoxic T-lymphocyte protein 4 relationship: RO:0002202 CL:0000896 ! develops from activated CD4-positive, alpha-beta T cell [Term] id: CL:0000903 name: natural T-regulatory cell def: "CD4-positive alpha-beta T cell with the phenotype FoxP3-positive, CD25-positive, CD62L-positive, and CTLA-4 positive with regulatory function." [GO_REF:0000031, GOC:add, GOC:pam, GOC:tfm, PMID:19464985] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "natural regulatory T cell" EXACT [] synonym: "natural regulatory T lymphocyte" EXACT [] synonym: "natural regulatory T-cell" EXACT [] synonym: "natural regulatory T-lymphocyte" EXACT [] synonym: "natural Treg" EXACT [] synonym: "nTreg" EXACT [] is_a: CL:0000792 {is_inferred="true"} ! CD4-positive, CD25-positive, alpha-beta regulatory T cell intersection_of: CL:0000792 ! CD4-positive, CD25-positive, alpha-beta regulatory T cell intersection_of: BFO:0000051 PR:000001350 ! has part forkhead box protein P3 intersection_of: RO:0002104 PR:000001318 ! has plasma membrane part L-selectin intersection_of: RO:0002104 PR:000001852 ! has plasma membrane part cytotoxic T-lymphocyte protein 4 intersection_of: RO:0002202 CL:0000809 ! develops from double-positive, alpha-beta thymocyte relationship: BFO:0000051 PR:000001350 ! has part forkhead box protein P3 relationship: RO:0002104 PR:000001318 ! has plasma membrane part L-selectin relationship: RO:0002104 PR:000001852 ! has plasma membrane part cytotoxic T-lymphocyte protein 4 relationship: RO:0002202 CL:0000809 ! develops from double-positive, alpha-beta thymocyte [Term] id: CL:0000904 name: central memory CD4-positive, alpha-beta T cell def: "CD4-positive, alpha-beta memory T cell with the phenotype CCR7-positive, CD127-positive, CD45RA-negative, CD45RO-positive, and CD25-negative." [GO_REF:0000031, GOC:add, GOC:pam, PMID:22343568] comment: This cell type is compatible with the HIPC Lyoplate markers for 'central memory CD4+ T cell', but includes additional markers known to be expressed on central memory CD4+ T cells. subset: cellxgene_subset subset: human_subset synonym: "central CD4-positive, alpha-beta memory T cell" EXACT [] synonym: "central CD4-positive, alpha-beta memory T lymphocyte" EXACT [] synonym: "central CD4-positive, alpha-beta memory T-cell" EXACT [] synonym: "central CD4-positive, alpha-beta memory T-lymphocyte" EXACT [] synonym: "central memory CD4+ T cell" BROAD [PMID:22343568] synonym: "central memory CD4-positive, alpha-beta T lymphocyte" EXACT [] synonym: "central memory CD4-positive, alpha-beta T-cell" EXACT [] synonym: "central memory CD4-positive, alpha-beta T-lymphocyte" EXACT [] is_a: CL:0001204 {is_inferred="true"} ! CD4-positive, alpha-beta memory T cell, CD45RO-positive intersection_of: CL:0001204 ! CD4-positive, alpha-beta memory T cell, CD45RO-positive intersection_of: CL:4030046 PR:000001015 ! lacks_plasma_membrane_part receptor-type tyrosine-protein phosphatase C isoform CD45RA intersection_of: CL:4030046 PR:000001380 ! lacks_plasma_membrane_part interleukin-2 receptor subunit alpha intersection_of: RO:0002104 PR:000001203 ! has plasma membrane part C-C chemokine receptor type 7 relationship: CL:4030046 PR:000001015 ! lacks_plasma_membrane_part receptor-type tyrosine-protein phosphatase C isoform CD45RA relationship: RO:0002104 PR:000001203 ! has plasma membrane part C-C chemokine receptor type 7 [Term] id: CL:0000905 name: effector memory CD4-positive, alpha-beta T cell def: "CD4-positive, alpha-beta memory T cell with the phenotype CCR7-negative, CD127-positive, CD45RA-negative, CD45RO-positive, and CD25-negative." [GO_REF:0000031, GOC:add, GOC:pam, GOC:tfm, PMID:22343568] comment: This cell type is compatible with the HIPC Lyoplate markers for 'effector memory CD4+ T cell', but includes additional markers known to be expressed on effector memory CD4+ T cells. subset: cellxgene_subset subset: human_reference_atlas subset: human_subset synonym: "effector CD4-positive, alpha-beta memory T cell" EXACT [] synonym: "effector CD4-positive, alpha-beta memory T lymphocyte" EXACT [] synonym: "effector CD4-positive, alpha-beta memory T-cell" EXACT [] synonym: "effector CD4-positive, alpha-beta memory T-lymphocyte" EXACT [] synonym: "effector memory CD4+ T cell" BROAD [PMID:22343568] synonym: "effector memory CD4-positive, alpha-beta T lymphocyte" EXACT [] synonym: "effector memory CD4-positive, alpha-beta T-cell" EXACT [] synonym: "effector memory CD4-positive, alpha-beta T-lymphocyte" EXACT [] is_a: CL:0001204 {is_inferred="true"} ! CD4-positive, alpha-beta memory T cell, CD45RO-positive intersection_of: CL:0001204 ! CD4-positive, alpha-beta memory T cell, CD45RO-positive intersection_of: CL:4030046 PR:000001015 ! lacks_plasma_membrane_part receptor-type tyrosine-protein phosphatase C isoform CD45RA intersection_of: CL:4030046 PR:000001203 ! lacks_plasma_membrane_part C-C chemokine receptor type 7 intersection_of: CL:4030046 PR:000001380 ! lacks_plasma_membrane_part interleukin-2 receptor subunit alpha relationship: CL:4030046 PR:000001015 ! lacks_plasma_membrane_part receptor-type tyrosine-protein phosphatase C isoform CD45RA relationship: CL:4030046 PR:000001203 ! lacks_plasma_membrane_part C-C chemokine receptor type 7 property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0000906 name: activated CD8-positive, alpha-beta T cell def: "A CD8-positive, alpha-beta T cell with the phenotype CD69-positive, CD62L-negative, CD127-negative, CD25-positive, and CCR7-negative." [GO_REF:0000031, GOC:add, GOC:pam, GOC:tfm] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "activated CD8-positive, alpha-beta T lymphocyte" EXACT [] synonym: "activated CD8-positive, alpha-beta T-cell" EXACT [] synonym: "activated CD8-positive, alpha-beta T-lymphocyte" EXACT [] is_a: CL:0000625 {is_inferred="true"} ! CD8-positive, alpha-beta T cell intersection_of: CL:0000625 ! CD8-positive, alpha-beta T cell intersection_of: CL:4030046 PR:000001203 ! lacks_plasma_membrane_part C-C chemokine receptor type 7 intersection_of: CL:4030046 PR:000001318 ! lacks_plasma_membrane_part L-selectin intersection_of: CL:4030046 PR:000001869 ! lacks_plasma_membrane_part interleukin-7 receptor subunit alpha intersection_of: RO:0002104 PR:000001343 ! has plasma membrane part CD69 molecule intersection_of: RO:0002104 PR:000001380 ! has plasma membrane part interleukin-2 receptor subunit alpha relationship: CL:4030046 PR:000001203 ! lacks_plasma_membrane_part C-C chemokine receptor type 7 relationship: CL:4030046 PR:000001318 ! lacks_plasma_membrane_part L-selectin relationship: CL:4030046 PR:000001869 ! lacks_plasma_membrane_part interleukin-7 receptor subunit alpha relationship: RO:0002104 PR:000001343 ! has plasma membrane part CD69 molecule relationship: RO:0002104 PR:000001380 ! has plasma membrane part interleukin-2 receptor subunit alpha relationship: RO:0002202 CL:0000900 ! develops from naive thymus-derived CD8-positive, alpha-beta T cell [Term] id: CL:0000907 name: central memory CD8-positive, alpha-beta T cell def: "CD8-positive, alpha-beta memory T cell with the phenotype CCR7-positive, CD127-positive, CD45RA-negative, CD45RO-positive, and CD25-negative." [GO_REF:0000031, GOC:add, GOC:pam, GOC:tfm, PMID:20146720, PMID:22343568] comment: This cell type is compatible with the HIPC Lyoplate markers for 'central memory CD8+ T cell', but includes additional markers known to be expressed on central memory CD8+ T cells. subset: cellxgene_subset subset: human_subset synonym: "central CD8-positive, alpha-beta memory T cell" EXACT [] synonym: "central CD8-positive, alpha-beta memory T lymphocyte" EXACT [] synonym: "central CD8-positive, alpha-beta memory T-cell" EXACT [] synonym: "central CD8-positive, alpha-beta memory T-lymphocyte" EXACT [] synonym: "central memory CD8+ T cell" BROAD [PMID:22343568] synonym: "central memory CD8-positive, alpha-beta T lymphocyte" EXACT [] synonym: "central memory CD8-positive, alpha-beta T-cell" EXACT [] synonym: "central memory CD8-positive, alpha-beta T-lymphocyte" EXACT [] is_a: CL:0001203 {is_inferred="true"} ! CD8-positive, alpha-beta memory T cell, CD45RO-positive intersection_of: CL:0001203 ! CD8-positive, alpha-beta memory T cell, CD45RO-positive intersection_of: CL:4030046 PR:000001015 ! lacks_plasma_membrane_part receptor-type tyrosine-protein phosphatase C isoform CD45RA intersection_of: CL:4030046 PR:000001380 ! lacks_plasma_membrane_part interleukin-2 receptor subunit alpha intersection_of: RO:0002104 PR:000001203 ! has plasma membrane part C-C chemokine receptor type 7 relationship: CL:4030046 PR:000001015 ! lacks_plasma_membrane_part receptor-type tyrosine-protein phosphatase C isoform CD45RA relationship: RO:0002104 PR:000001203 ! has plasma membrane part C-C chemokine receptor type 7 [Term] id: CL:0000908 name: CD8-positive, alpha-beta cytokine secreting effector T cell def: "A CD8-positive, alpha-beta T cell with the phenotype CD69-positive, CD62L-negative, CD127-negative, and CD25-positive, that secretes cytokines." [GO_REF:0000031, GOC:add, GOC:pam, GOC:tfm, PMID:20146720] subset: human_subset subset: mouse_subset synonym: "CD8-positive, alpha-beta cytokine secreting effector T lymphocyte" EXACT [] synonym: "CD8-positive, alpha-beta cytokine secreting effector T-cell" EXACT [] synonym: "CD8-positive, alpha-beta cytokine secreting effector T-lymphocyte" EXACT [] is_a: CL:0000625 {is_inferred="true"} ! CD8-positive, alpha-beta T cell intersection_of: CL:0000625 ! CD8-positive, alpha-beta T cell intersection_of: CL:4030046 PR:000001318 ! lacks_plasma_membrane_part L-selectin intersection_of: CL:4030046 PR:000001869 ! lacks_plasma_membrane_part interleukin-7 receptor subunit alpha intersection_of: RO:0002104 PR:000001343 ! has plasma membrane part CD69 molecule intersection_of: RO:0002104 PR:000001380 ! has plasma membrane part interleukin-2 receptor subunit alpha intersection_of: RO:0002215 GO:0001816 ! capable of cytokine production intersection_of: RO:0002353 GO:0030217 ! output of T cell differentiation relationship: CL:4030046 PR:000001318 ! lacks_plasma_membrane_part L-selectin relationship: CL:4030046 PR:000001869 ! lacks_plasma_membrane_part interleukin-7 receptor subunit alpha relationship: RO:0002104 PR:000001343 ! has plasma membrane part CD69 molecule relationship: RO:0002104 PR:000001380 ! has plasma membrane part interleukin-2 receptor subunit alpha relationship: RO:0002202 CL:0000906 ! develops from activated CD8-positive, alpha-beta T cell relationship: RO:0002215 GO:0001816 ! capable of cytokine production relationship: RO:0002353 GO:0030217 ! output of T cell differentiation [Term] id: CL:0000909 name: CD8-positive, alpha-beta memory T cell def: "A CD8-positive, alpha-beta T cell that has differentiated into a memory T cell." [GOC:add, PMID:20146720] subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "CD8-positive, alpha-beta memory T lymphocyte" EXACT [] synonym: "CD8-positive, alpha-beta memory T-cell" EXACT [] synonym: "CD8-positive, alpha-beta memory T-lymphocyte" EXACT [] synonym: "T.8Mem.Sp" RELATED [] is_a: CL:0000625 ! CD8-positive, alpha-beta T cell is_a: CL:0000813 ! memory T cell intersection_of: CL:0000625 ! CD8-positive, alpha-beta T cell intersection_of: RO:0000053 PATO:0001603 ! has characteristic increased life span intersection_of: RO:0002353 GO:0002286 ! output of T cell activation involved in immune response intersection_of: RO:0002353 GO:0043379 ! output of memory T cell differentiation property_value: RO:0002175 NCBITaxon:9606 property_value: terms:contributor https://orcid.org/0000-0001-9990-8331 [Term] id: CL:0000910 name: cytotoxic T cell def: "A mature T cell that differentiated and acquired cytotoxic function with the phenotype perforin-positive and granzyme-B positive." [GO_REF:0000031, GOC:add, GOC:pam, GOC:tfm, PMID:18395547] subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "cytotoxic T lymphocyte" EXACT [] synonym: "cytotoxic T-cell" EXACT [] synonym: "cytotoxic T-lymphocyte" EXACT [] xref: BTO:0000289 xref: CALOHA:TS-0190 xref: FMA:70573 is_a: CL:0000911 {is_inferred="true"} ! effector T cell intersection_of: CL:0000911 ! effector T cell intersection_of: RO:0002215 GO:0001913 ! capable of T cell mediated cytotoxicity relationship: RO:0002215 GO:0001913 ! capable of T cell mediated cytotoxicity property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0000911 name: effector T cell def: "A differentiated T cell with ability to traffic to peripheral tissues and is capable of mounting a specific immune response." [GOC:PAM-ADD, GOC:tfm, ISBN:0877799148, PMID:18395547] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "effector T lymphocyte" EXACT [] synonym: "effector T-cell" EXACT [] synonym: "effector T-lymphocyte" EXACT [] is_a: CL:0002419 {is_inferred="true"} ! mature T cell intersection_of: CL:0002419 ! mature T cell intersection_of: RO:0000053 PATO:0045026 ! has characteristic normal life span intersection_of: RO:0002353 GO:0030217 ! output of T cell differentiation intersection_of: RO:0002353 GO:0045058 ! output of T cell selection relationship: RO:0000053 PATO:0045026 ! has characteristic normal life span relationship: RO:0002353 GO:0030217 ! output of T cell differentiation [Term] id: CL:0000912 name: helper T cell def: "A effector T cell that provides help in the form of secreted cytokines to other immune cells." [GO_REF:0000031, GOC:add, GOC:pam, GOC:tfm, PMID:18395547] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "helper T lymphocyte" EXACT [] synonym: "helper T-cell" EXACT [] synonym: "helper T-lymphocyte" EXACT [] synonym: "T-helper cell" EXACT [] xref: BTO:0002417 xref: MESH:D006377 is_a: CL:0000911 {is_inferred="true"} ! effector T cell intersection_of: CL:0000911 ! effector T cell intersection_of: RO:0002215 GO:0001816 ! capable of cytokine production relationship: RO:0002215 GO:0001816 ! capable of cytokine production [Term] id: CL:0000913 name: effector memory CD8-positive, alpha-beta T cell def: "CD8-positive, alpha-beta memory T cell with the phenotype CCR7-negative, CD127-positive, CD45RA-negative, CD45RO-positive, and CD25-negative." [GO_REF:0000031, GOC:add, GOC:pam, PMID:20146720, PMID:22343568] comment: This cell type is compatible with the HIPC Lyoplate markers for 'effector memory CD8+ T cell', but includes additional markers known to be expressed on effector memory CD8+ T cells. subset: cellxgene_subset subset: human_reference_atlas subset: human_subset synonym: "effector CD8-positive, alpha-beta memory T cell" EXACT [] synonym: "effector CD8-positive, alpha-beta memory T lymphocyte" EXACT [] synonym: "effector CD8-positive, alpha-beta memory T-cell" EXACT [] synonym: "effector CD8-positive, alpha-beta memory T-lymphocyte" EXACT [] synonym: "effector memory CD8+ T cell" BROAD [PMID:22343568] synonym: "effector memory CD8-positive, alpha-beta T lymphocyte" EXACT [] synonym: "effector memory CD8-positive, alpha-beta T-cell" EXACT [] synonym: "effector memory CD8-positive, alpha-beta T-lymphocyte" EXACT [] is_a: CL:0001203 {is_inferred="true"} ! CD8-positive, alpha-beta memory T cell, CD45RO-positive intersection_of: CL:0001203 ! CD8-positive, alpha-beta memory T cell, CD45RO-positive intersection_of: CL:4030046 PR:000001015 ! lacks_plasma_membrane_part receptor-type tyrosine-protein phosphatase C isoform CD45RA intersection_of: CL:4030046 PR:000001203 ! lacks_plasma_membrane_part C-C chemokine receptor type 7 intersection_of: CL:4030046 PR:000001380 ! lacks_plasma_membrane_part interleukin-2 receptor subunit alpha relationship: CL:4030046 PR:000001015 ! lacks_plasma_membrane_part receptor-type tyrosine-protein phosphatase C isoform CD45RA relationship: CL:4030046 PR:000001203 ! lacks_plasma_membrane_part C-C chemokine receptor type 7 property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0000914 name: immature NK T cell def: "An immature alpha-beta T-cell that express Egr2. These cells give rise to T cells expressing NK markers." [GO_REF:0000031, GOC:add, GOC:pam, GOC:tfm, PMID:17589542, PMID:19169262] subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "immature NK T lymphocyte" EXACT [] synonym: "immature NK T-cell" EXACT [] synonym: "immature NK T-lymphocyte" EXACT [] synonym: "immature NKT cell" EXACT [] is_a: CL:0000790 {is_inferred="true"} ! immature alpha-beta T cell intersection_of: CL:0000790 ! immature alpha-beta T cell intersection_of: BFO:0000051 PR:000003469 ! has part early growth response protein 2 relationship: BFO:0000051 PR:000003469 ! has part early growth response protein 2 relationship: RO:0002202 CL:0000809 ! develops from double-positive, alpha-beta thymocyte property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0000915 name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell def: "An alpha-beta intraepithelial T cell with the phenotype CD8-alpha-alpha-positive located in the columnar epithelium of the gastrointestinal tract. These cells have a memory phenotype of CD2-negative and CD5-negative." [GO_REF:0000031, GOC:add, GOC:pam, PMID:11685222] subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "CD8-alpha-alpha-positive, alpha-beta intraepithelial T lymphocyte" EXACT [] synonym: "CD8-alpha-alpha-positive, alpha-beta intraepithelial T-cell" EXACT [] synonym: "CD8-alpha-alpha-positive, alpha-beta intraepithelial T-lymphocyte" EXACT [] is_a: CL:0000797 {is_inferred="true"} ! alpha-beta intraepithelial T cell intersection_of: CL:0000797 ! alpha-beta intraepithelial T cell intersection_of: CL:4030046 PR:000001083 ! lacks_plasma_membrane_part CD2 molecule intersection_of: CL:4030046 PR:000001839 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD5 intersection_of: RO:0002104 PR:000001084 ! has plasma membrane part T-cell surface glycoprotein CD8 alpha chain relationship: CL:4030046 PR:000001083 ! lacks_plasma_membrane_part CD2 molecule relationship: CL:4030046 PR:000001839 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD5 relationship: RO:0002104 PR:000001084 ! has plasma membrane part T-cell surface glycoprotein CD8 alpha chain relationship: RO:0002202 CL:0000811 ! develops from CD8-positive, alpha-beta thymocyte property_value: RO:0002175 NCBITaxon:9606 property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0000915" xsd:string {name="CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell on CELLxGENE CellGuide"} property_value: terms:description "The CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell, often abbreviated as CD8αα IEL, is a specialized immune cell found within the epithelial layer of mucosal surfaces, such as the intestines. CD8αα IEL have been studied extensively in mice, but equivalent cells are thought to be present in humans, albeit at lower numbers. \nThese cells represent a subset of intraepithelial T lymphocytes characterized by the expression of both CD8-alpha-alpha homodimer and the alpha-beta variant of the T cell receptor (TCR). Other features shared with intraepithelial T lymphocytes include the expression of T-bet, a master transcription factor that controls expression of proinflammatory cytokines, natural killer cell receptors, and an activated phenotype (high expression of CD69). \nFunctionally, CD8αα IELs are thought to play a role in maintaining epithelial integrity, local immune surveillance, and protection against microbial pathogens. Upon detecting alterations associated with infection or inflammation, these cells orchestrate immune responses to restore tissue homeostasis, primarily through the secretion of cytokines and chemokines, and directly eliminating infected cells. \nCD8αα IELs have been shown require β2 microglobulin-dependent MHC class I expression for their generation and/or homeostasis. They share some characteristics with natural killer cells and might have similar suppressive and regulatory roles which they perform through the production of IL-10 and TGFβ. For example, they have been shown the prevent induced colitis, indicating that by modulating immune responses, CD8αα IELs prevent excessive and damaging immune activation that can lead to chronic inflammatory conditions or autoimmunity.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1016/j.coi.2019.04.010", xref="DOI:10.1093/cei/uxad049", xref="DOI:10.1111/j.1600-065X.2006.00488.x", xref="DOI:10.3389/fimmu.2022.1059042"} [Term] id: CL:0000916 name: dendritic epidermal T cell def: "A mature gamma-delta T cell located in the epidermis that regulates wound healing." [GO_REF:0000031, GOC:add, GOC:pam, GOC:tfm, PMID:11976459] comment: In mice, DETC have an invariant T cell receptor. subset: human_subset subset: mouse_subset synonym: "dendritic epidermal T lymphocyte" EXACT [] synonym: "dendritic epidermal T-cell" EXACT [] synonym: "dendritic epidermal T-lymphocyte" EXACT [] synonym: "DETC" EXACT [] is_a: CL:0000800 {is_inferred="true"} ! mature gamma-delta T cell intersection_of: CL:0000800 ! mature gamma-delta T cell intersection_of: RO:0001025 UBERON:0001003 ! located in skin epidermis intersection_of: RO:0002215 GO:0060054 ! capable of positive regulation of epithelial cell proliferation involved in wound healing relationship: RO:0001025 UBERON:0001003 ! located in skin epidermis relationship: RO:0002202 CL:0002401 ! develops from mature dendritic epithelial T cell precursor relationship: RO:0002215 GO:0060054 ! capable of positive regulation of epithelial cell proliferation involved in wound healing [Term] id: CL:0000917 name: Tc1 cell def: "A CD8-positive, alpha-beta positive T cell that has the phenotype T-bet-positive, eomesodermin-positive, CXCR3-positive, CCR6-negative, and is capable of producing interferon-gamma." [GO_REF:0000031, GOC:add, GOC:pam, PMID:22343568, PMID:9914231] comment: This cell type is compatible with the HIPC Lyoplate markers for 'Tc1 CD8+ T cell', but its logical definition includes additional known characteristics of Tc1 T cells. subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "CD8-positive Th1 cell" EXACT [] synonym: "T-cytotoxic T cell type 1" EXACT [] synonym: "Tc1 CD8+ T cell" EXACT [PMID:22343568] synonym: "Tc1 T cell" EXACT [] synonym: "Tc1 T lymphocyte" EXACT [] synonym: "Tc1 T-cell" EXACT [] synonym: "Tc1 T-lymphocyte" EXACT [] synonym: "Th1 CD8-positive T cell" EXACT [] synonym: "Th1 non-TFH CD8-positive T cell" EXACT [] xref: BTO:0004793 xref: BTO:0004888 xref: FMA:84793 is_a: CL:0000908 {is_inferred="true"} ! CD8-positive, alpha-beta cytokine secreting effector T cell intersection_of: CL:0000908 ! CD8-positive, alpha-beta cytokine secreting effector T cell intersection_of: BFO:0000051 PR:000001835 ! has part T-box transcription factor TBX21 intersection_of: BFO:0000051 PR:000003463 ! has part eomesodermin intersection_of: CL:4030046 PR:000001202 ! lacks_plasma_membrane_part C-C chemokine receptor type 6 intersection_of: RO:0002104 PR:000001207 ! has plasma membrane part C-X-C chemokine receptor type 3 intersection_of: RO:0002215 GO:0032609 ! capable of type II interferon production relationship: BFO:0000051 PR:000001835 ! has part T-box transcription factor TBX21 relationship: BFO:0000051 PR:000003463 ! has part eomesodermin relationship: CL:4030046 PR:000001202 ! lacks_plasma_membrane_part C-C chemokine receptor type 6 relationship: RO:0002104 PR:000001207 ! has plasma membrane part C-X-C chemokine receptor type 3 relationship: RO:0002215 GO:0032609 ! capable of type II interferon production [Term] id: CL:0000918 name: Tc2 cell def: "A CD8-positive, alpha-beta positive T cell expressing GATA-3 and secreting IL-4." [GO_REF:0000031, GOC:add, GOC:pam, GOC:tfm, PMID:9914231] comment: This cell type is compatible with the HIPC Lyoplate markers for 'non-Tc1/Tc17 CD8+ T cell' (see CL:0001052), but includes the additional necessary and sufficient conditions to allow classification as a Tc2 T cell. subset: human_subset subset: mouse_subset synonym: "CD8-positive Th2 cell" EXACT [] synonym: "T-cytotoxic T cell type 2" EXACT [] synonym: "Tc2 T cell" EXACT [] synonym: "Tc2 T lymphocyte" EXACT [] synonym: "Tc2 T-cell" EXACT [] synonym: "Tc2 T-lymphocyte" EXACT [] synonym: "Th2 CD8-positive T cell" EXACT [] synonym: "Th2 non-TFH CD8-positive T cell" EXACT [] xref: BTO:0004794 xref: FMA:84794 is_a: CL:0000908 {is_inferred="true"} ! CD8-positive, alpha-beta cytokine secreting effector T cell is_a: CL:0001052 ! CD8-positive, CXCR3-negative, CCR6-negative, alpha-beta T cell intersection_of: CL:0000908 ! CD8-positive, alpha-beta cytokine secreting effector T cell intersection_of: BFO:0000051 PR:000001941 ! has part trans-acting T-cell-specific transcription factor GATA-3 intersection_of: CL:4030046 PR:000001202 ! lacks_plasma_membrane_part C-C chemokine receptor type 6 intersection_of: CL:4030046 PR:000001207 ! lacks_plasma_membrane_part C-X-C chemokine receptor type 3 intersection_of: RO:0002215 GO:0032633 ! capable of interleukin-4 production relationship: BFO:0000051 PR:000001941 ! has part trans-acting T-cell-specific transcription factor GATA-3 relationship: RO:0002215 GO:0032633 ! capable of interleukin-4 production [Term] id: CL:0000919 name: CD8-positive, CD25-positive, alpha-beta regulatory T cell def: "A CD8-positive alpha beta-positive T cell with the phenotype FoxP3-positive and having suppressor function." [GO_REF:0000031, GOC:add, GOC:pam, GOC:tfm, PMID:19118505] subset: human_subset subset: mouse_subset synonym: "CD8+CD25+ T cell" EXACT [] synonym: "CD8+CD25+ T lymphocyte" EXACT [] synonym: "CD8+CD25+ T(reg)" EXACT [] synonym: "CD8+CD25+ T-cell" EXACT [] synonym: "CD8+CD25+ T-lymphocyte" EXACT [] synonym: "CD8+CD25+ Treg" EXACT [] synonym: "CD8-positive, CD25-positive Treg" EXACT [] synonym: "CD8-positive, CD25-positive, alpha-beta regulatory T lymphocyte" EXACT [] synonym: "CD8-positive, CD25-positive, alpha-beta regulatory T-cell" EXACT [] synonym: "CD8-positive, CD25-positive, alpha-beta regulatory T-lymphocyte" EXACT [] is_a: CL:0000795 {is_inferred="true"} ! CD8-positive, alpha-beta regulatory T cell intersection_of: CL:0000795 ! CD8-positive, alpha-beta regulatory T cell intersection_of: BFO:0000051 PR:000001350 ! has part forkhead box protein P3 intersection_of: RO:0002104 PR:000001380 ! has plasma membrane part interleukin-2 receptor subunit alpha relationship: BFO:0000051 PR:000001350 ! has part forkhead box protein P3 relationship: RO:0002104 PR:000001380 ! has plasma membrane part interleukin-2 receptor subunit alpha relationship: RO:0002202 CL:0000906 ! develops from activated CD8-positive, alpha-beta T cell [Term] id: CL:0000920 name: CD8-positive, CD28-negative, alpha-beta regulatory T cell def: "CD8-positive, alpha-beta positive regulatory T cell with the phenotype CD28-negative and FoxP3-positive." [GO_REF:0000031, GOC:add, GOC:pam, GOC:tfm, PMID:19118505] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "CD8+CD28- T cell" EXACT [] synonym: "CD8+CD28- T lymphocyte" EXACT [] synonym: "CD8+CD28- T(reg)" EXACT [] synonym: "CD8+CD28- T-cell" EXACT [] synonym: "CD8+CD28- T-lymphocyte" EXACT [] synonym: "CD8+CD28- Treg" EXACT [] synonym: "CD8-positive, CD28-negative T(reg)" EXACT [] synonym: "CD8-positive, CD28-negative Treg" EXACT [] synonym: "CD8-positive, CD28-negative, alpha-beta regulatory T lymphocyte" EXACT [] synonym: "CD8-positive, CD28-negative, alpha-beta regulatory T-cell" EXACT [] synonym: "CD8-positive, CD28-negative, alpha-beta regulatory T-lymphocyte" EXACT [] is_a: CL:0000795 {is_inferred="true"} ! CD8-positive, alpha-beta regulatory T cell intersection_of: CL:0000795 ! CD8-positive, alpha-beta regulatory T cell intersection_of: BFO:0000051 PR:000001350 ! has part forkhead box protein P3 intersection_of: CL:4030046 PR:000001841 ! lacks_plasma_membrane_part T-cell-specific surface glycoprotein CD28 relationship: BFO:0000051 PR:000001350 ! has part forkhead box protein P3 relationship: CL:4030046 PR:000001841 ! lacks_plasma_membrane_part T-cell-specific surface glycoprotein CD28 relationship: RO:0002202 CL:0000906 ! develops from activated CD8-positive, alpha-beta T cell [Term] id: CL:0000921 name: type I NK T cell def: "An alpha-beta T cell expressing NK cell markers that is CD1d restricted and expresses specific V-alpha chains. NK T cells of this type recognize the glycolipid alpha-galactosylceramide in the context of CD1d." [GO_REF:0000031, GOC:add, GOC:pam, GOC:tfm, PMID:15039760] comment: In mouse the canonical TCR is V-alpha-14, and in humans it is V-alpha 24. subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "classical NK T cell" EXACT [] synonym: "invariant NK T cell" RELATED [] synonym: "type I NK T lymphocyte" EXACT [] synonym: "type I NK T-cell" EXACT [] synonym: "type I NK T-lymphocyte" EXACT [] synonym: "type I NKT cell" EXACT [] is_a: CL:0000814 {is_inferred="true"} ! mature NK T cell intersection_of: CL:0000814 ! mature NK T cell intersection_of: RO:0002215 GO:0043208 ! capable of glycosphingolipid binding relationship: RO:0002215 GO:0043208 ! capable of glycosphingolipid binding property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0000922 name: type II NK T cell def: "An alpha-beta T cell expressing NK call markers that is CD1d restricted and expresses a diverse TCR repertoire. Type II NKT cells do not become activated by alpha-galactosylceramide when presented by CD1d." [GO_REF:0000031, GOC:add, GOC:pam, GOC:tfm, PMID:15039760] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "type II NK T lymphocyte" EXACT [] synonym: "type II NK T-cell" EXACT [] synonym: "type II NK T-lymphocyte" EXACT [] synonym: "type II NKT cell" EXACT [] is_a: CL:0000814 {is_inferred="true"} ! mature NK T cell intersection_of: CL:0000814 ! mature NK T cell intersection_of: RO:0002215 GO:0002288 ! capable of NK T cell activation involved in immune response relationship: RO:0002215 GO:0002288 ! capable of NK T cell activation involved in immune response [Term] id: CL:0000923 name: CD4-positive type I NK T cell def: "A type I NK T cell that has the phenotype CD4-positive." [GO_REF:0000031, GOC:add, GOC:pam, GOC:tfm, PMID:17303398] subset: human_subset subset: mouse_subset synonym: "CD4-positive type I NK T lymphocyte" EXACT [] synonym: "CD4-positive type I NK T-cell" EXACT [] synonym: "CD4-positive type I NK T-lymphocyte" EXACT [] synonym: "CD4-positive type I NKT cell" EXACT [] synonym: "NKT.4+.SP" NARROW [] is_a: CL:0000921 {is_inferred="true"} ! type I NK T cell intersection_of: CL:0000921 ! type I NK T cell intersection_of: RO:0002104 PR:000001004 ! has plasma membrane part CD4 molecule relationship: RO:0002104 PR:000001004 ! has plasma membrane part CD4 molecule [Term] id: CL:0000924 name: CD4-negative, CD8-negative type I NK T cell def: "A type I NK T cell that has the phenotype CD4-negative and CD8-negative." [GO_REF:0000031, GOC:add, GOC:pam, GOC:tfm, PMID:18997862] subset: human_subset subset: mouse_subset synonym: "CD4-negative, CD8-negative type I NK T lymphocyte" EXACT [] synonym: "CD4-negative, CD8-negative type I NK T-cell" EXACT [] synonym: "CD4-negative, CD8-negative type I NK T-lymphocyte" EXACT [] synonym: "CD4-negative, CD8-negative type I NKT cell" EXACT [] synonym: "NKT.4-.Sp" NARROW [] is_a: CL:0000921 {is_inferred="true"} ! type I NK T cell intersection_of: CL:0000921 ! type I NK T cell intersection_of: CL:4030046 PR:000001004 ! lacks_plasma_membrane_part CD4 molecule intersection_of: CL:4030046 PR:000001084 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD8 alpha chain relationship: CL:4030046 PR:000001004 ! lacks_plasma_membrane_part CD4 molecule relationship: CL:4030046 PR:000001084 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD8 alpha chain [Term] id: CL:0000925 name: activated CD4-positive type I NK T cell def: "A type I NK T cell that has been recently activated, secretes interferon-gamma and IL-4, and has the phenotype CD4-positive, CD69-positive, and downregulated NK markers." [GO_REF:0000031, GOC:add, GOC:pam, GOC:tfm, PMID:17303398] subset: human_subset subset: mouse_subset synonym: "activated CD4-positive type I NK T lymphocyte" EXACT [] synonym: "activated CD4-positive type I NK T-cell" EXACT [] synonym: "activated CD4-positive type I NK T-lymphocyte" EXACT [] synonym: "activated CD4-positive type I NKT cell" EXACT [] is_a: CL:0000923 ! CD4-positive type I NK T cell intersection_of: CL:0000921 ! type I NK T cell intersection_of: RO:0002104 PR:000001004 ! has plasma membrane part CD4 molecule intersection_of: RO:0002104 PR:000001343 ! has plasma membrane part CD69 molecule intersection_of: RO:0002215 GO:0032609 ! capable of type II interferon production intersection_of: RO:0002215 GO:0032633 ! capable of interleukin-4 production relationship: RO:0002104 PR:000001343 ! has plasma membrane part CD69 molecule relationship: RO:0002202 CL:0000923 ! develops from CD4-positive type I NK T cell relationship: RO:0002215 GO:0032609 ! capable of type II interferon production relationship: RO:0002215 GO:0032633 ! capable of interleukin-4 production [Term] id: CL:0000926 name: CD4-positive type I NK T cell secreting interferon-gamma def: "A mature NK T cell that secretes interferon-gamma and enhances type 1 immune responses." [GO_REF:0000031, GOC:add, GOC:pam, GOC:tfm, PMID:17303398] subset: human_subset subset: mouse_subset synonym: "CD4-positive type I NK T cell secreting IFN-gamma" EXACT [] synonym: "CD4-positive type I NK T lymphocyte secreting interferon-gamma" EXACT [] synonym: "CD4-positive type I NK T-cell secreting interferon-gamma" EXACT [] synonym: "CD4-positive type I NK T-lymphocyte secreting interferon-gamma" EXACT [] synonym: "CD4-positive type I NKT cell secreting interferon-gamma" EXACT [] is_a: CL:0000923 ! CD4-positive type I NK T cell intersection_of: CL:0000921 ! type I NK T cell intersection_of: RO:0002104 PR:000001004 ! has plasma membrane part CD4 molecule intersection_of: RO:0002215 GO:0002827 ! capable of positive regulation of T-helper 1 type immune response intersection_of: RO:0002215 GO:0032609 ! capable of type II interferon production relationship: RO:0002202 CL:0000925 ! develops from activated CD4-positive type I NK T cell relationship: RO:0002215 GO:0002827 ! capable of positive regulation of T-helper 1 type immune response relationship: RO:0002215 GO:0032609 ! capable of type II interferon production [Term] id: CL:0000927 name: CD4-positive type I NK T cell secreting interleukin-4 def: "A mature NK T cell that predominantly secretes type 2 cytokines such as interleukin-4 and interleukin-13 and enhances type 2 immune responses." [GO_REF:0000031, GOC:add, GOC:pam, GOC:tfm] subset: human_subset subset: mouse_subset synonym: "CD4-positive type I NK T cell secreting IL-4" EXACT [] synonym: "CD4-positive type I NK T lymphocyte secreting interleukin-4" EXACT [] synonym: "CD4-positive type I NK T-cell secreting interleukin-4" EXACT [] synonym: "CD4-positive type I NK T-lymphocyte secreting interleukin-4" EXACT [] synonym: "CD4-positive type I NKT cell secreting interleukin-4" EXACT [] is_a: CL:0000923 ! CD4-positive type I NK T cell intersection_of: CL:0000921 ! type I NK T cell intersection_of: RO:0002104 PR:000001004 ! has plasma membrane part CD4 molecule intersection_of: RO:0002215 GO:0002830 ! capable of positive regulation of type 2 immune response intersection_of: RO:0002215 GO:0032616 ! capable of interleukin-13 production intersection_of: RO:0002215 GO:0032633 ! capable of interleukin-4 production relationship: RO:0002202 CL:0000925 ! develops from activated CD4-positive type I NK T cell relationship: RO:0002215 GO:0002830 ! capable of positive regulation of type 2 immune response relationship: RO:0002215 GO:0032616 ! capable of interleukin-13 production relationship: RO:0002215 GO:0032633 ! capable of interleukin-4 production [Term] id: CL:0000928 name: activated CD4-negative, CD8-negative type I NK T cell def: "A type I NK T cell that has been recently activated, secretes interferon-gamma and interleukin-4, and has phenotype CD4-negative, CD8-negative, CD69-positive, and downregulated NK markers." [GO_REF:0000031, GOC:add, GOC:pam, GOC:tfm, PMID:17303398] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "activated CD4-negative, CD8-negative type I NK T lymphocyte" EXACT [] synonym: "activated CD4-negative, CD8-negative type I NK T-cell" EXACT [] synonym: "activated CD4-negative, CD8-negative type I NK T-lymphocyte" EXACT [] synonym: "activated CD4-negative, CD8-negative type I NKT cell" EXACT [] is_a: CL:0000924 ! CD4-negative, CD8-negative type I NK T cell intersection_of: CL:0000921 ! type I NK T cell intersection_of: CL:4030046 PR:000001004 ! lacks_plasma_membrane_part CD4 molecule intersection_of: CL:4030046 PR:000001084 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD8 alpha chain intersection_of: RO:0002104 PR:000001343 ! has plasma membrane part CD69 molecule intersection_of: RO:0002215 GO:0002369 ! capable of T cell cytokine production relationship: RO:0002104 PR:000001343 ! has plasma membrane part CD69 molecule relationship: RO:0002202 CL:0000924 ! develops from CD4-negative, CD8-negative type I NK T cell relationship: RO:0002215 GO:0002369 ! capable of T cell cytokine production [Term] id: CL:0000929 name: CD4-negative, CD8-negative type I NK T cell secreting interferon-gamma def: "A mature NK T cell that secretes interferon-gamma and enhances Th1 immune responses." [GO_REF:0000031, GOC:add, GOC:pam, GOC:tfm, PMID:17303398] subset: human_subset subset: mouse_subset synonym: "CD4-negative, CD8-negative type I NK T cell secreting IFN-gamma" EXACT [] synonym: "CD4-negative, CD8-negative type I NK T lymphocyte secreting interferon-gamma" EXACT [] synonym: "CD4-negative, CD8-negative type I NK T-cell secreting interferon-gamma" EXACT [] synonym: "CD4-negative, CD8-negative type I NK T-lymphocyte secreting interferon-gamma" EXACT [] synonym: "CD4-negative, CD8-negative type I NKT cell secreting interferon-gamma" EXACT [] is_a: CL:0000924 ! CD4-negative, CD8-negative type I NK T cell intersection_of: CL:0000921 ! type I NK T cell intersection_of: CL:4030046 PR:000001004 ! lacks_plasma_membrane_part CD4 molecule intersection_of: CL:4030046 PR:000001084 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD8 alpha chain intersection_of: RO:0002215 GO:0002827 ! capable of positive regulation of T-helper 1 type immune response intersection_of: RO:0002215 GO:0032609 ! capable of type II interferon production relationship: RO:0002202 CL:0000928 ! develops from activated CD4-negative, CD8-negative type I NK T cell relationship: RO:0002215 GO:0002827 ! capable of positive regulation of T-helper 1 type immune response relationship: RO:0002215 GO:0032609 ! capable of type II interferon production [Term] id: CL:0000930 name: CD4-negative, CD8-negative type I NK T cell secreting interleukin-4 def: "A mature NK T cell that secretes interleukin-4 and enhances Th2 immune responses." [GO_REF:0000031, GOC:add, GOC:pam, GOC:tfm, PMID:17303398] subset: human_subset subset: mouse_subset synonym: "CD4-negative, CD8-negative type I NK T cell secreting IL-4" EXACT [] synonym: "CD4-negative, CD8-negative type I NK T lymphocyte secreting interleukin-4" EXACT [] synonym: "CD4-negative, CD8-negative type I NK T-cell secreting interleukin-4" EXACT [] synonym: "CD4-negative, CD8-negative type I NK T-lymphocyte secreting interleukin-4" EXACT [] synonym: "CD4-negative, CD8-negative type I NKT cell secreting interleukin-4" EXACT [] is_a: CL:0000924 ! CD4-negative, CD8-negative type I NK T cell intersection_of: CL:0000921 ! type I NK T cell intersection_of: CL:4030046 PR:000001004 ! lacks_plasma_membrane_part CD4 molecule intersection_of: CL:4030046 PR:000001084 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD8 alpha chain intersection_of: RO:0002215 GO:0002830 ! capable of positive regulation of type 2 immune response intersection_of: RO:0002215 GO:0032633 ! capable of interleukin-4 production relationship: RO:0002202 CL:0000928 ! develops from activated CD4-negative, CD8-negative type I NK T cell relationship: RO:0002215 GO:0002830 ! capable of positive regulation of type 2 immune response relationship: RO:0002215 GO:0032633 ! capable of interleukin-4 production [Term] id: CL:0000931 name: activated type II NK T cell def: "A type II NK T cell that has been recently activated, secretes interferon-gamma and interleukin-4, and has the phenotype CD69-positive and downregulated NK markers." [GO_REF:0000031, GOC:add, GOC:pam, GOC:tfm, PMID:17964217] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "activated type II NK T lymphocyte" EXACT [] synonym: "activated type II NK T-cell" EXACT [] synonym: "activated type II NK T-lymphocyte" EXACT [] synonym: "activated type II NKT cell" EXACT [] is_a: CL:0000922 {is_inferred="true"} ! type II NK T cell intersection_of: CL:0000922 ! type II NK T cell intersection_of: RO:0002104 PR:000001343 ! has plasma membrane part CD69 molecule intersection_of: RO:0002215 GO:0002369 ! capable of T cell cytokine production relationship: RO:0002104 PR:000001343 ! has plasma membrane part CD69 molecule relationship: RO:0002215 GO:0002369 ! capable of T cell cytokine production [Term] id: CL:0000932 name: type II NK T cell secreting interferon-gamma def: "A type II NK T cell that has been recently activated, secretes interferon-gamma, and has the phenotype CD69-positive and downregulated NK markers." [GO_REF:0000031, GOC:add, GOC:pam, PMID:17964217] subset: human_subset subset: mouse_subset synonym: "type II NK T cell secreting IFN-gamma" EXACT [] synonym: "type II NK T lymphocyte secreting interferon-gamma" EXACT [] synonym: "type II NK T-cell secreting interferon-gamma" EXACT [] synonym: "type II NK T-lymphocyte secreting interferon-gamma" EXACT [] synonym: "type II NKT cell secreting interferon-gamma" EXACT [] is_a: CL:0000922 {is_inferred="true"} ! type II NK T cell intersection_of: CL:0000922 ! type II NK T cell intersection_of: RO:0002104 PR:000001343 ! has plasma membrane part CD69 molecule intersection_of: RO:0002215 GO:0032609 ! capable of type II interferon production relationship: RO:0002104 PR:000001343 ! has plasma membrane part CD69 molecule relationship: RO:0002202 CL:0000931 ! develops from activated type II NK T cell relationship: RO:0002215 GO:0032609 ! capable of type II interferon production [Term] id: CL:0000933 name: type II NK T cell secreting interleukin-4 def: "A type II NK T cell that has been recently activated, secretes interleukin-4, and has the phenotype CD69-positive and downregulated NK markers." [GO_REF:0000031, GOC:add, GOC:pam, GOC:tfm, PMID:17964217] subset: human_subset subset: mouse_subset synonym: "type II NK T cell secreting IL-4" EXACT [] synonym: "type II NK T lymphocyte secreting interleukin-4" EXACT [] synonym: "type II NK T-cell secreting interleukin-4" EXACT [] synonym: "type II NK T-lymphocyte secreting interleukin-4" EXACT [] synonym: "type II NKT cell secreting interleukin-4" EXACT [] is_a: CL:0000922 {is_inferred="true"} ! type II NK T cell intersection_of: CL:0000922 ! type II NK T cell intersection_of: RO:0002104 PR:000001343 ! has plasma membrane part CD69 molecule intersection_of: RO:0002215 GO:0032633 ! capable of interleukin-4 production relationship: RO:0002104 PR:000001343 ! has plasma membrane part CD69 molecule relationship: RO:0002202 CL:0000931 ! develops from activated type II NK T cell relationship: RO:0002215 GO:0032633 ! capable of interleukin-4 production [Term] id: CL:0000934 name: CD4-positive, alpha-beta cytotoxic T cell def: "A CD4-positive, alpha-beta T cell that has cytotoxic function." [GO_REF:0000031, GOC:add, GOC:pam, GOC:tfm, PMID:18440213] subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "CD4-positive, alpha-beta cytotoxic T lymphocyte" EXACT [] synonym: "CD4-positive, alpha-beta cytotoxic T-cell" EXACT [] synonym: "CD4-positive, alpha-beta cytotoxic T-lymphocyte" EXACT [] is_a: CL:0000624 {is_inferred="true"} ! CD4-positive, alpha-beta T cell intersection_of: CL:0000624 ! CD4-positive, alpha-beta T cell intersection_of: RO:0002215 GO:0001913 ! capable of T cell mediated cytotoxicity intersection_of: RO:0002353 GO:0030217 ! output of T cell differentiation relationship: RO:0002202 CL:0000896 ! develops from activated CD4-positive, alpha-beta T cell relationship: RO:0002215 GO:0001913 ! capable of T cell mediated cytotoxicity relationship: RO:0002353 GO:0030217 ! output of T cell differentiation property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0000935 name: CD4-negative, CD8-negative, alpha-beta intraepithelial T cell def: "A CD4-negative, CD8-negative, alpha-beta intraepithelial T cell that is found in the columnar epithelium of the gastrointestinal tract." [GO_REF:0000031, GOC:add, GOC:pam, PMID:11685222] subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "CD4-negative, CD8-negative, alpha-beta intraepithelial T lymphocyte" EXACT [] synonym: "CD4-negative, CD8-negative, alpha-beta intraepithelial T-cell" EXACT [] synonym: "CD4-negative, CD8-negative, alpha-beta intraepithelial T-lymphocyte" EXACT [] is_a: CL:0000797 {is_inferred="true"} ! alpha-beta intraepithelial T cell intersection_of: CL:0000797 ! alpha-beta intraepithelial T cell intersection_of: CL:4030046 PR:000001004 ! lacks_plasma_membrane_part CD4 molecule intersection_of: CL:4030046 PR:000025403 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD8 alpha chain isoform 1 relationship: CL:4030046 PR:000001004 ! lacks_plasma_membrane_part CD4 molecule relationship: CL:4030046 PR:000025403 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD8 alpha chain isoform 1 property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0000936 name: early lymphoid progenitor def: "A lymphoid progenitor cell that is found in bone marrow, gives rise to B cells, T cells, natural killer cells and dendritic cells, and has the phenotype Lin-negative, Kit-positive, Sca-1-positive, FLT3-positive, CD34-positive, CD150 negative, and GlyA-negative." [GO_REF:0000031, GOC:add, GOC:dsd, GOC:pam, GOC:tfm, PMID:19022770] comment: Markers are associated with mouse cells. ELP transcription factors include E2A-positive, Ikaros-positive, EBF-negative, Pax5-negative, PU.1-negative. subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "ELP" RELATED OMO:0003000 [] synonym: "GMLP" RELATED OMO:0003000 [PMID:18371378] synonym: "LMPP" RELATED OMO:0003000 [] synonym: "lymphoid-primed multipotent progenitor" EXACT [] is_a: CL:0000837 {is_inferred="true"} ! hematopoietic multipotent progenitor cell is_a: CL:0011026 ! progenitor cell intersection_of: CL:0000837 ! hematopoietic multipotent progenitor cell intersection_of: CL:4030046 PR:000001024 ! lacks_plasma_membrane_part neural cell adhesion molecule 1 intersection_of: CL:4030046 PR:000001460 ! lacks_plasma_membrane_part glycophorin-A intersection_of: RO:0002104 PR:000002001 ! has plasma membrane part receptor-type tyrosine-protein kinase FLT3 intersection_of: RO:0002104 PR:000002065 ! has plasma membrane part mast/stem cell growth factor receptor intersection_of: RO:0002104 PR:000002979 ! has plasma membrane part lymphocyte antigen 6A-2/6E-1 intersection_of: RO:0002215 GO:0030098 ! capable of lymphocyte differentiation relationship: CL:4030046 PR:000001460 ! lacks_plasma_membrane_part glycophorin-A relationship: RO:0002104 PR:000002001 ! has plasma membrane part receptor-type tyrosine-protein kinase FLT3 relationship: RO:0002104 PR:000002065 ! has plasma membrane part mast/stem cell growth factor receptor relationship: RO:0002104 PR:000002979 ! has plasma membrane part lymphocyte antigen 6A-2/6E-1 relationship: RO:0002202 CL:0002035 ! develops from Slamf1-negative multipotent progenitor cell relationship: RO:0002215 GO:0030098 ! capable of lymphocyte differentiation property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0000937 name: pre-natural killer cell def: "Cell committed to natural killer cell lineage that has the phenotype CD122-positive, CD34-positive, and CD117-positive. This cell type lacks expression of natural killer receptor proteins." [GO_REF:0000031, GOC:add, GOC:dsd, GOC:pam, GOC:tfm, PMID:16551251, PMID:17100874] comment: These cells are also reportedly CD7-low, CD10-negative, CD45RA-positive, alpha-4-beta-7 integrin-high. subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "pre-NK cell" EXACT [] is_a: CL:0000623 ! natural killer cell intersection_of: CL:0000623 ! natural killer cell intersection_of: RO:0002104 PR:000001003 ! has plasma membrane part CD34 molecule intersection_of: RO:0002104 PR:000001381 ! has plasma membrane part interleukin-2 receptor subunit beta intersection_of: RO:0002104 PR:000002065 ! has plasma membrane part mast/stem cell growth factor receptor relationship: RO:0002104 PR:000001003 ! has plasma membrane part CD34 molecule relationship: RO:0002104 PR:000001381 ! has plasma membrane part interleukin-2 receptor subunit beta relationship: RO:0002104 PR:000002065 ! has plasma membrane part mast/stem cell growth factor receptor [Term] id: CL:0000938 name: CD16-negative, CD56-bright natural killer cell, human def: "NK cell that has the phenotype CD56-bright, CD16-negative, and CD84-positive with the function to secrete interferon-gamma but is not cytotoxic." [GO_REF:0000031, GOC:add, GOC:pam, GOC:tfm, PMID:19796267, PMID:22343568] comment: This cell type is compatible with the HIPC Lyoplate markers for 'CD16-CD56bright NK cell'. Markers are associated with human cell types. subset: cellxgene_subset subset: human_reference_atlas subset: human_subset synonym: "CD16-CD56bright NK cell" EXACT [PMID:22343568] synonym: "CD16-negative, CD56-bright NK cell" EXACT [] synonym: "CD56-bright cytokine secreting natural killer cell" EXACT [] synonym: "CD56-bright cytokine secreting NK cell" EXACT [] is_a: CL:0000824 ! mature natural killer cell intersection_of: CL:0000824 ! mature natural killer cell intersection_of: CL:4030046 PR:000001483 ! lacks_plasma_membrane_part low affinity immunoglobulin gamma Fc region receptor III intersection_of: CL:4030046 PR:000002015 ! lacks_plasma_membrane_part MHC class II histocompatibility antigen alpha chain DRA intersection_of: RO:0002104 PR:000001319 ! has plasma membrane part SLAM family member 5 intersection_of: RO:0002162 NCBITaxon:9606 ! in taxon Homo sapiens intersection_of: RO:0002215 GO:0032609 ! capable of type II interferon production intersection_of: RO:0015015 PR:000001024 ! has high plasma membrane amount neural cell adhesion molecule 1 relationship: CL:4030046 PR:000001483 ! lacks_plasma_membrane_part low affinity immunoglobulin gamma Fc region receptor III relationship: CL:4030046 PR:000002015 ! lacks_plasma_membrane_part MHC class II histocompatibility antigen alpha chain DRA relationship: RO:0002104 PR:000001319 ! has plasma membrane part SLAM family member 5 relationship: RO:0002162 NCBITaxon:9606 ! in taxon Homo sapiens relationship: RO:0015015 PR:000001024 ! has high plasma membrane amount neural cell adhesion molecule 1 property_value: RO:0002175 NCBITaxon:9606 property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0000938" xsd:string {name="CD16-negative, CD56-bright natural killer cell, human on CELLxGENE CellGuide"} property_value: terms:description "The CD16-negative, CD56-bright natural killer (NK) cell is a subtype of human natural killer cells that plays a pivotal role in the innate immune response. These cells are identified primarily by the lack of CD16, a low-affinity receptor for the Fc region of immunoglobulins G, and high expression of CD56 protein, a neural cell adhesion molecule, on the cell surface. This unique receptor pattern characterizes the regulatory role of these cells in the immune system and distinguishes them from their counterparts - the CD16-positive, CD56-dim NK cells, which have cytotoxic killing actions instead.\nCD16-negative, CD56-bright NK cells are specialized in immunomodulation and this trait is manifested primarily through the release of substantial amounts of cytokines, including TNF, IFN-gamma, GM-CSF, and especially IL-10, when they interact with specific target cells or in response to stimulation by cytokines such as IL-12, IL-15, and IL-18. Thus, these cells form a significant link between innate and adaptive immunity.\nFurthermore, these cells have tropism for secondary lymphoid tissues, where they frequently interact with dendritic cells, contributing to the modulation of dendritic cell maturation and function. This intimate crosstalk between CD16-negative, CD56-bright NK cells and dendritic cells is crucial for the orchestration of both innate and adaptive immune responses. Hence, while the term 'natural killer cell' may suggest a primary role in cell killing, this particular subset of NK cells exert their effects mainly through immune regulation and interaction with other immune cells.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.3389/fimmu.2014.00159", xref="DOI:10.4049/jimmunol.1502570", xref="DOI:10.4049/jimmunol.173.10.6418"} [Term] id: CL:0000939 name: CD16-positive, CD56-dim natural killer cell, human def: "A mature natural killer cell that has the phenotype CD56-low, CD16-positive and which is capable of cytotoxicity and cytokine production." [GO_REF:0000031, GOC:add, GOC:pam, PMID:19796267, PMID:22343568] comment: This cell type is compatible with the HIPC Lyoplate markers for 'CD16+CD56+ NK cell'. Markers are associated with human cell types. subset: cellxgene_subset subset: human_subset synonym: "CD16+CD56+ NK cell" EXACT [PMID:22343568] synonym: "CD16-positive, CD56-dim NK cell" EXACT [] synonym: "CD16-positive, CD56-low natural killer cell" EXACT [] synonym: "CD16-positive, CD56-low NK cell" EXACT [] synonym: "CD16-positive, CD56-positive natural killer cell" EXACT [] synonym: "CD16-positive, CD56-positive NK cell" EXACT [] synonym: "cytotoxic CD56-dim natural killer cell" EXACT [] synonym: "cytotoxic CD56-dim NK cell" EXACT [] is_a: CL:0000824 ! mature natural killer cell intersection_of: CL:0000824 ! mature natural killer cell intersection_of: CL:4030046 PR:000002015 ! lacks_plasma_membrane_part MHC class II histocompatibility antigen alpha chain DRA intersection_of: RO:0002104 PR:000001483 ! has plasma membrane part low affinity immunoglobulin gamma Fc region receptor III intersection_of: RO:0002162 NCBITaxon:9606 ! in taxon Homo sapiens intersection_of: RO:0002215 GO:0001816 ! capable of cytokine production intersection_of: RO:0002215 GO:0042267 ! capable of natural killer cell mediated cytotoxicity intersection_of: RO:0015016 PR:000001024 ! has low plasma membrane amount neural cell adhesion molecule 1 relationship: CL:4030046 PR:000002015 ! lacks_plasma_membrane_part MHC class II histocompatibility antigen alpha chain DRA relationship: RO:0002104 PR:000001483 ! has plasma membrane part low affinity immunoglobulin gamma Fc region receptor III relationship: RO:0002162 NCBITaxon:9606 ! in taxon Homo sapiens relationship: RO:0002215 GO:0042267 ! capable of natural killer cell mediated cytotoxicity relationship: RO:0015016 PR:000001024 ! has low plasma membrane amount neural cell adhesion molecule 1 [Term] id: CL:0000940 name: mucosal-associated invariant T cell def: "An alpha-beta T cell that is found in the lamina propria of mucosal tissues and is restricted by the MR-1 molecule. This cell develops from double-positive, alpha-beta thymocyte." [GO_REF:0000031, GOC:add, GOC:pam, GOC:tfm, PMID:19416870, PMID:33352411] subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "MAIT" RELATED OMO:0003000 [PMID:40781543] synonym: "mucosal invariant T cell" EXACT [] synonym: "mucosal invariant T lymphocyte" EXACT [] synonym: "mucosal invariant T-cell" EXACT [] synonym: "mucosal invariant T-lymphocyte" EXACT [] synonym: "mucosal-associated invariant T lymphocyte" EXACT [] synonym: "mucosal-associated invariant T-cell" EXACT [] synonym: "mucosal-associated invariant T-lymphocyte" EXACT [] is_a: CL:0000791 {is_inferred="true"} ! mature alpha-beta T cell intersection_of: CL:0000791 ! mature alpha-beta T cell intersection_of: RO:0002215 GO:0002227 ! capable of innate immune response in mucosa intersection_of: RO:0002215 GO:0032394 ! capable of MHC class Ib receptor activity intersection_of: RO:0002353 GO:0030217 ! output of T cell differentiation relationship: RO:0002202 CL:0000809 ! develops from double-positive, alpha-beta thymocyte relationship: RO:0002215 GO:0002227 ! capable of innate immune response in mucosa relationship: RO:0002215 GO:0032394 ! capable of MHC class Ib receptor activity relationship: RO:0002353 GO:0030217 ! output of T cell differentiation property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0000941 name: thymic conventional dendritic cell def: "A dendritic cell arising in thymus that has the phenotype CD11c-positive, CD11b-negative, and CD45RA-negative." [GO_REF:0000031, GOC:add, GOC:pam, PMID:19273629] comment: In the mouse this cell expresses CD8-alpha-alpha. subset: human_subset subset: mouse_subset is_a: CL:0000990 {is_inferred="true"} ! conventional dendritic cell intersection_of: CL:0000990 ! conventional dendritic cell intersection_of: BFO:0000050 UBERON:0002370 ! part of thymus intersection_of: CL:4030046 PR:000001012 ! lacks_plasma_membrane_part integrin alpha-M intersection_of: CL:4030046 PR:000001015 ! lacks_plasma_membrane_part receptor-type tyrosine-protein phosphatase C isoform CD45RA intersection_of: RO:0002104 PR:000001013 ! has plasma membrane part integrin alpha-X relationship: BFO:0000050 UBERON:0002370 ! part of thymus relationship: CL:4030046 PR:000001012 ! lacks_plasma_membrane_part integrin alpha-M relationship: CL:4030046 PR:000001015 ! lacks_plasma_membrane_part receptor-type tyrosine-protein phosphatase C isoform CD45RA relationship: RO:0002202 CL:0000894 ! develops from DN1 thymic pro-T cell [Term] id: CL:0000942 name: thymic plasmacytoid dendritic cell def: "A plasmacytoid dendritic cell developing in the thymus with phenotype CD11c-negative or low, CD45RA-positive, CD11b-negative, and CD123-positive." [GO_REF:0000031, GOC:add, GOC:pam, GOC:tfm, PMID:19941119] subset: human_reference_atlas subset: human_subset subset: mouse_subset is_a: CL:0000784 {is_inferred="true"} ! plasmacytoid dendritic cell intersection_of: CL:0000784 ! plasmacytoid dendritic cell intersection_of: BFO:0000050 UBERON:0002370 ! part of thymus intersection_of: CL:4030046 PR:000001012 ! lacks_plasma_membrane_part integrin alpha-M intersection_of: RO:0002104 PR:000001015 ! has plasma membrane part receptor-type tyrosine-protein phosphatase C isoform CD45RA intersection_of: RO:0002104 PR:000001865 ! has plasma membrane part interleukin-3 receptor class 2 alpha chain relationship: BFO:0000050 UBERON:0002370 ! part of thymus relationship: CL:4030046 PR:000001012 ! lacks_plasma_membrane_part integrin alpha-M relationship: RO:0002104 PR:000001015 ! has plasma membrane part receptor-type tyrosine-protein phosphatase C isoform CD45RA relationship: RO:0002104 PR:000001865 ! has plasma membrane part interleukin-3 receptor class 2 alpha chain relationship: RO:0002202 CL:0000894 ! develops from DN1 thymic pro-T cell property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/2d-ftu/thymus-thymus-lobule/v1.3/assets/2d-ftu-thymus-thymus-lobule.png" xsd:string {terms:licence="http://creativecommons.org/licenses/by/4.0/", xref="doi:10.48539/HBM322.LZLG.752"} property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0000943 name: Be1 Cell def: "A Be cell that facilitates development of T-helper 1 (Th1) phenotype in CD4-positive T cells, and secretes high levels of interleukin-2, tumor necrosis factor-alpha and interferon-gamma." [GO_REF:0000031, GOC:dsd, GOC:msz, GOC:tfm, PMID:11101868, PMID:20224569] comment: Be1 cells are also reportedly capable of secreting IL-6, IL-10, and IL-12. They are also reportedly CD11b-negative and B220-positive. subset: human_subset subset: mouse_subset synonym: "B effector 1 cell" EXACT [PMID:11101868, PMID:20224569] synonym: "B effector cell type 1" RELATED [] is_a: CL:0000968 {is_inferred="true"} ! Be cell intersection_of: CL:0000968 ! Be cell intersection_of: RO:0002215 GO:0032609 ! capable of type II interferon production intersection_of: RO:0002215 GO:0032623 ! capable of interleukin-2 production intersection_of: RO:0002215 GO:0032640 ! capable of tumor necrosis factor production intersection_of: RO:0002215 GO:0045627 ! capable of positive regulation of T-helper 1 cell differentiation relationship: RO:0002215 GO:0032609 ! capable of type II interferon production relationship: RO:0002215 GO:0032623 ! capable of interleukin-2 production relationship: RO:0002215 GO:0032640 ! capable of tumor necrosis factor production relationship: RO:0002215 GO:0045627 ! capable of positive regulation of T-helper 1 cell differentiation [Term] id: CL:0000944 name: Be2 cell def: "A Be cell that facilitates development of T-helper 2 (Th2) phenotype T cells, and secretes high levels of interleukin-2, interleukin-10, interleukin-4, and interleukin-6." [GO_REF:0000031, GOC:dsd, GOC:msz, GOC:tfm, PMID:11101868, PMID:20224569] comment: Be2 cells are also reportedly capable of secreting IL-13 and TNF. They are also reportedly CD11b-negative and B220-positive. subset: human_subset subset: mouse_subset synonym: "B effector 2 cell" EXACT [PMID:11101868, PMID:20224569] synonym: "B effector cell type 2" RELATED [] is_a: CL:0000968 {is_inferred="true"} ! Be cell intersection_of: CL:0000968 ! Be cell intersection_of: RO:0002215 GO:0032613 ! capable of interleukin-10 production intersection_of: RO:0002215 GO:0032623 ! capable of interleukin-2 production intersection_of: RO:0002215 GO:0032633 ! capable of interleukin-4 production intersection_of: RO:0002215 GO:0032635 ! capable of interleukin-6 production intersection_of: RO:0002215 GO:0045630 ! capable of positive regulation of T-helper 2 cell differentiation relationship: RO:0002215 GO:0032613 ! capable of interleukin-10 production relationship: RO:0002215 GO:0032623 ! capable of interleukin-2 production relationship: RO:0002215 GO:0032633 ! capable of interleukin-4 production relationship: RO:0002215 GO:0032635 ! capable of interleukin-6 production relationship: RO:0002215 GO:0045630 ! capable of positive regulation of T-helper 2 cell differentiation [Term] id: CL:0000945 name: lymphocyte of B lineage def: "A lymphocyte of B lineage with the commitment to express an immunoglobulin complex." [GO_REF:0000031, GOC:add, GOC:rhs, GOC:tfm, ISBN:0781735149] comment: Types of B lineage lymphocytes include B cells and antibody secreting cells (plasmablasts and plasma cells). Lymphocytes of B cell lineage can be distinguished from those of T cell lineage by their lack of CD3e (as part of the T cell receptor complex). subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset is_a: CL:0000542 {is_inferred="true"} ! lymphocyte relationship: RO:0002202 CL:0000826 ! develops from pro-B cell property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0000946 name: antibody secreting cell def: "A lymphocyte of B lineage that is devoted to secreting large amounts of immunoglobulin." [GO_REF:0000031, GOC:add, GOC:tfm, ISBN:0721601464, ISBN:0781735149] subset: cellxgene_subset subset: human_subset subset: mouse_subset is_a: CL:0000945 {is_inferred="true"} ! lymphocyte of B lineage intersection_of: CL:0000945 ! lymphocyte of B lineage intersection_of: RO:0003000 GO:0042571 ! produces immunoglobulin complex, circulating relationship: RO:0003000 GO:0042571 ! produces immunoglobulin complex, circulating property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0000946" xsd:string {name="antibody secreting cell on CELLxGENE CellGuide"} property_value: terms:description "Antibody secreting cells, such as short-lived plasmablasts and long-lived plasma cells, form a key component of the adaptive immune system. These cells originate from B-lymphocytes upon exposure to antigens. They are primarily characterized by their capacity to produce and secrete large amounts of antibodies (immunoglobulins) that help to neutralize the pathogens, defining the primary role of these cells in the humoral immune response. \nAntibody secreting cells are found predominantly within the lymph nodes, spleen, and mucosa-associated lymphoid tissues. They are characterized by an extensive rough endoplasmic reticulum, reflecting the high antibody production. The interesting dynamics of these cells, switching from a nonsecreting, antigen-specific B-cell state to a high-rate immunoglobulin-secreting cell state, is a major factor in sustaining an effective adaptive immune system: Derived from a single clone, the secreted immunoglobulins have a unique antigen specificity inherited from the parent B cell. They are able to recognize specific extracellular antigens, aiding in marking harmful invaders such as viruses and bacteria for elimination, either by direct neutralization or by recruiting other immune cells for assistance.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1002/eji.1830161018", xref="DOI:10.1038/nri3795"} [Term] id: CL:0000947 name: IgE plasma cell def: "A long lived plasma cell that secretes IgE." [GO_REF:0000031, GOC:msz, ISBN:781735149] subset: human_subset subset: mouse_subset is_a: CL:0000974 {is_inferred="true"} ! long lived plasma cell intersection_of: CL:0000974 ! long lived plasma cell intersection_of: RO:0003000 GO:0071743 ! produces IgE immunoglobulin complex, circulating relationship: RO:0003000 GO:0071743 ! produces IgE immunoglobulin complex, circulating [Term] id: CL:0000948 name: IgE memory B cell def: "A class switched memory B cell that expresses IgE on the cell surface." [GO_REF:0000031, GOC:rhs, ISBN:0781765196] subset: human_subset subset: mouse_subset synonym: "IgE memory B lymphocyte" EXACT [] synonym: "IgE memory B-cell" EXACT [] synonym: "IgE memory B-lymphocyte" EXACT [] synonym: "memory IgE B cell" EXACT [] synonym: "memory IgE B lymphocyte" EXACT [] synonym: "memory IgE B-cell" EXACT [] synonym: "memory IgE B-lymphocyte" EXACT [] is_a: CL:4052108 ! IgD-negative class switched memory B cell intersection_of: CL:0000972 ! class switched memory B cell intersection_of: RO:0002104 GO:0071742 ! has plasma membrane part IgE immunoglobulin complex relationship: RO:0002104 GO:0071742 ! has plasma membrane part IgE immunoglobulin complex [Term] id: CL:0000949 name: IgD plasmablast def: "A plasmablast that secretes IgD, and which occur in a small proportion of B cells in the adult." [GO_REF:0000031, GOC:msz] subset: human_subset subset: mouse_subset is_a: CL:0000980 {is_inferred="true"} ! plasmablast intersection_of: CL:0000980 ! plasmablast intersection_of: RO:0003000 GO:0071739 ! produces IgD immunoglobulin complex, circulating relationship: RO:0003000 GO:0071739 ! produces IgD immunoglobulin complex, circulating [Term] id: CL:0000950 name: IgE plasmablast def: "A plasmablast that secretes IgE." [GO_REF:0000031, GOC:msz] subset: human_subset subset: mouse_subset is_a: CL:0000980 {is_inferred="true"} ! plasmablast intersection_of: CL:0000980 ! plasmablast intersection_of: RO:0003000 GO:0071743 ! produces IgE immunoglobulin complex, circulating relationship: RO:0003000 GO:0071743 ! produces IgE immunoglobulin complex, circulating [Term] id: CL:0000951 name: IgE short lived plasma cell def: "A short lived plasma cell that secretes IgE." [GO_REF:0000031, GOC:msz, ISBN:781735149] subset: human_subset subset: mouse_subset is_a: CL:0000975 {is_inferred="true"} ! short lived plasma cell intersection_of: CL:0000975 ! short lived plasma cell intersection_of: RO:0003000 GO:0071743 ! produces IgE immunoglobulin complex, circulating relationship: RO:0003000 GO:0071743 ! produces IgE immunoglobulin complex, circulating [Term] id: CL:0000952 name: preBCR-positive large pre-B-II cell def: "An preBRC-positive large pre-B-II cell is a large pre-B-II cell that is pre-B cell receptor-positive, composed of surrogate light chain protein (SL), which is composed of VpreB , Lambda 5/14.1, in complex with immunoglobulin mu heavy chain (IgHmu) on the cell surface." [GO_REF:0000031, GOC:rhs, GOC:tfm, PMID:9785673] subset: human_subset subset: mouse_subset is_a: CL:0000957 {is_inferred="true"} ! large pre-B-II cell intersection_of: CL:0000957 ! large pre-B-II cell intersection_of: CL:4030044 GO:0071708 ! has_not_completed immunoglobulin light chain V-J recombination intersection_of: RO:0002104 GO:0035369 ! has plasma membrane part pre-B cell receptor complex intersection_of: RO:0002104 PR:000001858 ! has plasma membrane part immunoglobulin iota chain intersection_of: RO:0002104 PR:000001859 ! has plasma membrane part immunoglobulin lambda-like polypeptide 1 relationship: CL:4030044 GO:0071708 ! has_not_completed immunoglobulin light chain V-J recombination relationship: RO:0002104 GO:0035369 ! has plasma membrane part pre-B cell receptor complex relationship: RO:0002104 PR:000001858 ! has plasma membrane part immunoglobulin iota chain relationship: RO:0002104 PR:000001859 ! has plasma membrane part immunoglobulin lambda-like polypeptide 1 [Term] id: CL:0000953 name: preBCR-negative large pre-B-II cell def: "A pre-BCR-negative large pre-B-II cell is a large pre-B-II cell that is pre-B cell receptor-negative, composed of surrogate light chain protein (SL), which is composed of VpreB and Lambda 5/14.1, in complex with immunoglobulin mu heavy chain (IgHmu), on the cell surface, and lack a DNA rearrangement of immunoglobulin light chain genes." [GO_REF:0000031, GOC:rhs, GOC:tfm, PMID:9785673] subset: human_subset subset: mouse_subset is_a: CL:0000957 {is_inferred="true"} ! large pre-B-II cell intersection_of: CL:0000957 ! large pre-B-II cell intersection_of: CL:4030044 GO:0071708 ! has_not_completed immunoglobulin light chain V-J recombination intersection_of: CL:4030046 GO:0035369 ! lacks_plasma_membrane_part pre-B cell receptor complex intersection_of: CL:4030046 PR:000001858 ! lacks_plasma_membrane_part immunoglobulin iota chain intersection_of: CL:4030046 PR:000001859 ! lacks_plasma_membrane_part immunoglobulin lambda-like polypeptide 1 relationship: CL:4030044 GO:0071708 ! has_not_completed immunoglobulin light chain V-J recombination relationship: CL:4030046 GO:0035369 ! lacks_plasma_membrane_part pre-B cell receptor complex relationship: CL:4030046 PR:000001858 ! lacks_plasma_membrane_part immunoglobulin iota chain relationship: CL:4030046 PR:000001859 ! lacks_plasma_membrane_part immunoglobulin lambda-like polypeptide 1 [Term] id: CL:0000954 name: small pre-B-II cell def: "A small pre-B-II cell is a pre-B-II cell that is Rag1-positive, Rag2-positive, pre-BCR-negative, and BCR-negative, is not proliferating, and carries a DNA rearrangement of one or more immunoglobulin light chain genes." [GO_REF:0000031, GOC:dsd, GOC:rhs, GOC:tfm, PMID:16551251, PMID:18432934, PMID:9785673] comment: Small pre-B-II cells are also reportedly CD10-positive, CD19-positive, CD34-negative, CD79a-positive, CD127-negative, TdT-negative, Vpre-B-negative, sIgM-negative, and sIgD-negative. Transcription factors: PU.1-positive, Ikaros-positive, E2A-positive, and PAX5-positive. subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "small pre-BII cell" EXACT [] is_a: CL:0000955 {is_inferred="true"} ! pre-B-II cell intersection_of: CL:0000955 ! pre-B-II cell intersection_of: BFO:0000051 PR:000003457 ! has part V(D)J recombination-activating protein 1 intersection_of: BFO:0000051 PR:000003460 ! has part V(D)J recombination-activating protein 2 intersection_of: CL:4030046 GO:0019815 ! lacks_plasma_membrane_part B cell receptor complex intersection_of: CL:4030046 GO:0035369 ! lacks_plasma_membrane_part pre-B cell receptor complex intersection_of: RO:0000056 GO:0071708 ! participates in immunoglobulin light chain V-J recombination relationship: BFO:0000051 PR:000003457 ! has part V(D)J recombination-activating protein 1 relationship: BFO:0000051 PR:000003460 ! has part V(D)J recombination-activating protein 2 relationship: CL:4030046 GO:0019815 ! lacks_plasma_membrane_part B cell receptor complex relationship: CL:4030046 GO:0035369 ! lacks_plasma_membrane_part pre-B cell receptor complex relationship: RO:0000056 GO:0071708 ! participates in immunoglobulin light chain V-J recombination [Term] id: CL:0000955 name: pre-B-II cell def: "A pre-B-II cell is a precursor B cell that expresses immunoglobulin mu heavy chain (IgHmu+), and lack expression of CD34, TdT, immunoglobulin kappa light chain and immunoglobulin lambda light chain." [GO_REF:0000031, GOC:dsd, GOC:rhs, GOC:tfm, PMID:9785673] comment: pre-B-II cell are also reportedly CD19-positive, CD22-positive, CD38-positive, CD45-positive, and CD48-positive. subset: human_subset subset: mouse_subset synonym: "pre-B-lymphocyte" EXACT [] synonym: "pre-BII cell" EXACT [] xref: BTO:0001133 xref: CALOHA:TS-0819 is_a: CL:0000817 {is_inferred="true"} ! precursor B cell intersection_of: CL:0000817 ! precursor B cell intersection_of: CL:4030045 PR:000006611 ! lacks_part DNA nucleotidylexotransferase intersection_of: CL:4030046 PR:000001003 ! lacks_plasma_membrane_part CD34 molecule intersection_of: RO:0002353 GO:0071707 ! output of immunoglobulin heavy chain V-D-J recombination disjoint_from: CL:0000956 ! pre-B-I cell relationship: CL:4030045 PR:000006611 ! lacks_part DNA nucleotidylexotransferase relationship: CL:4030046 PR:000001003 ! lacks_plasma_membrane_part CD34 molecule relationship: RO:0002353 GO:0071707 ! output of immunoglobulin heavy chain V-D-J recombination [Term] id: CL:0000956 name: pre-B-I cell def: "A pre-B-I cell is a precursor B cell that expresses CD34 and surrogate immunoglobulin light chain (VpreB , Lambda 5 (mouse)/14.1 (human)) on the cell surface, and TdT, Rag1,and Rag2 intracellularly. Cell type carries a D-JH DNA rearrangement, and lacks expression of immunglobulin heavy chain protein." [GO_REF:0000031, GOC:dsd, GOC:rhs, GOC:tfm, PMID:16551251, PMID:18432934, PMID:20839338, PMID:9785673] comment: Human pre-B-I cells are reportedly CD10-positive, CD19-positive, CD22-positive, CD38-positive, CD45-low, CD79a-positive, CD127-negative, pre-BCR-negative, IgM-negative, IgD-negative, and Tdt-positive. Transcription factors expressed: Pax5-positive. subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "pre-BI cell" EXACT [] synonym: "pro-B cell (Philadelphia nomenclature)" RELATED [PMID:11244048] is_a: CL:0000817 {is_inferred="true"} ! precursor B cell intersection_of: CL:0000817 ! precursor B cell intersection_of: BFO:0000051 PR:000003457 ! has part V(D)J recombination-activating protein 1 intersection_of: BFO:0000051 PR:000003460 ! has part V(D)J recombination-activating protein 2 intersection_of: BFO:0000051 PR:000006611 ! has part DNA nucleotidylexotransferase intersection_of: RO:0000056 GO:0071707 ! participates in immunoglobulin heavy chain V-D-J recombination intersection_of: RO:0002104 PR:000001003 ! has plasma membrane part CD34 molecule intersection_of: RO:0002104 PR:000001858 ! has plasma membrane part immunoglobulin iota chain intersection_of: RO:0002104 PR:000001859 ! has plasma membrane part immunoglobulin lambda-like polypeptide 1 relationship: BFO:0000051 PR:000003457 ! has part V(D)J recombination-activating protein 1 relationship: BFO:0000051 PR:000003460 ! has part V(D)J recombination-activating protein 2 relationship: BFO:0000051 PR:000006611 ! has part DNA nucleotidylexotransferase relationship: RO:0000056 GO:0071707 ! participates in immunoglobulin heavy chain V-D-J recombination relationship: RO:0002104 PR:000001003 ! has plasma membrane part CD34 molecule relationship: RO:0002104 PR:000001858 ! has plasma membrane part immunoglobulin iota chain relationship: RO:0002104 PR:000001859 ! has plasma membrane part immunoglobulin lambda-like polypeptide 1 [Term] id: CL:0000957 name: large pre-B-II cell def: "A large pre-B-II cell is a pre-B-II cell that is proliferating and is Rag1-negative and Rag2-negative." [GO_REF:0000031, GOC:dsd, GOC:rhs, PMID:16551251, PMID:18432934, PMID:9785673] comment: Large pre-B-II cells are also reportedly CD10-positive, CD19-positive, CD34-negative, CD79a-positive, CD127-negative, TdT-negative, Vpre-B-positive, pre-BCR-positive, sIgM-negative, and sIgD-negative. Transcription factors: PU.1-positive, Ikaros-positive, E2A-positive, and PAX5-positive. subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "large pre-B cell" BROAD [PMID:11244048] synonym: "large pre-BII cell" EXACT [] is_a: CL:0000955 {is_inferred="true"} ! pre-B-II cell intersection_of: CL:0000955 ! pre-B-II cell intersection_of: CL:4030045 PR:000003457 ! lacks_part V(D)J recombination-activating protein 1 intersection_of: CL:4030045 PR:000003460 ! lacks_part V(D)J recombination-activating protein 2 intersection_of: RO:0000056 GO:0046651 ! participates in lymphocyte proliferation relationship: CL:4030045 PR:000003457 ! lacks_part V(D)J recombination-activating protein 1 relationship: CL:4030045 PR:000003460 ! lacks_part V(D)J recombination-activating protein 2 relationship: RO:0000056 GO:0046651 ! participates in lymphocyte proliferation [Term] id: CL:0000958 name: T1 B cell def: "A transitional stage B cell that migrates from the bone marrow into the peripheral circulation, and finally to the spleen. This cell type has the phenotype surface IgM-positive, surface IgD-negative, CD21-negative, CD23-negative, and CD62L-negative, and CD93-positive. This cell type has also been described as IgM-high, CD19-positive, B220-positive, AA4-positive, and CD23-negative." [GO_REF:0000031, GOC:dsd, GOC:msz, GOC:tfm, PMCID:PMC2193793, PMID:12810111] comment: T1 B cells are also reportedly CD10-negative/positive??, CD20-positive, CD24-positive, CD38-positive, CD48-positive, CD84-positive, CD150-positive, CD244-negative, and CD352-positive. subset: human_subset subset: mouse_subset synonym: "T1 B lymphocyte" EXACT [] synonym: "T1 B-cell" EXACT [] synonym: "T1 B-lymphocyte" EXACT [] synonym: "transitional stage 1 B cell" EXACT [] is_a: CL:0000818 {is_inferred="true"} ! transitional stage B cell intersection_of: CL:0000818 ! transitional stage B cell intersection_of: CL:4030046 GO:0071738 ! lacks_plasma_membrane_part IgD immunoglobulin complex intersection_of: CL:4030046 PR:000001318 ! lacks_plasma_membrane_part L-selectin intersection_of: CL:4030046 PR:000001338 ! lacks_plasma_membrane_part complement receptor type 2 intersection_of: CL:4030046 PR:000001880 ! lacks_plasma_membrane_part low affinity immunoglobulin epsilon Fc receptor intersection_of: RO:0002104 PR:000002037 ! has plasma membrane part complement component C1q receptor relationship: CL:4030046 GO:0071738 ! lacks_plasma_membrane_part IgD immunoglobulin complex relationship: CL:4030046 PR:000001318 ! lacks_plasma_membrane_part L-selectin relationship: CL:4030046 PR:000001338 ! lacks_plasma_membrane_part complement receptor type 2 relationship: CL:4030046 PR:000001880 ! lacks_plasma_membrane_part low affinity immunoglobulin epsilon Fc receptor relationship: RO:0002104 PR:000002037 ! has plasma membrane part complement component C1q receptor [Term] id: CL:0000959 name: T2 B cell def: "A transitional stage B cell that has the phenotype surface IgM-positive, surface IgD-postive, CD21-positive, CD23-positive, CD62L-negative, CD93-positive and is located in the splenic B follicles. This cell type has also been described as IgM-high, CD19-positive, B220-positive, AA4-positive, and CD23-positive." [GO_REF:0000031, GOC:dsd, GOC:msz, GOC:tfm, PMCID:PMC2193793, PMID:12810111] comment: T2 B cells are also reportedly CD20-positive, CD24-positive, CD38-positive, CD48-positive, CD84-positive, CD150-positive, CD244-negative, and CD352-positive. subset: human_subset subset: mouse_subset synonym: "T2 B lymphocyte" EXACT [] synonym: "T2 B-cell" EXACT [] synonym: "T2 B-lymphocyte" EXACT [] synonym: "transitional stage 2 B cell" EXACT [] is_a: CL:0000818 {is_inferred="true"} ! transitional stage B cell intersection_of: CL:0000818 ! transitional stage B cell intersection_of: CL:4030046 PR:000001318 ! lacks_plasma_membrane_part L-selectin intersection_of: RO:0002104 GO:0071738 ! has plasma membrane part IgD immunoglobulin complex intersection_of: RO:0002104 GO:0071753 ! has plasma membrane part IgM immunoglobulin complex intersection_of: RO:0002104 PR:000001338 ! has plasma membrane part complement receptor type 2 intersection_of: RO:0002104 PR:000001880 ! has plasma membrane part low affinity immunoglobulin epsilon Fc receptor intersection_of: RO:0002104 PR:000002037 ! has plasma membrane part complement component C1q receptor relationship: CL:4030046 PR:000001318 ! lacks_plasma_membrane_part L-selectin relationship: RO:0002104 GO:0071738 ! has plasma membrane part IgD immunoglobulin complex relationship: RO:0002104 PR:000001338 ! has plasma membrane part complement receptor type 2 relationship: RO:0002104 PR:000001880 ! has plasma membrane part low affinity immunoglobulin epsilon Fc receptor relationship: RO:0002104 PR:000002037 ! has plasma membrane part complement component C1q receptor relationship: RO:0002202 CL:0000958 ! develops from T1 B cell [Term] id: CL:0000960 name: T3 B cell def: "A transitional stage B cell that expresses surface IgM and IgD, and CD62L. This cell type appears to be an anergic B cell that does not proliferate upon BCR signaling, is found in the spleen and lymph nodes, and has the phenotype surface IgM-positive, surface IgD-positive, CD21-positive, CD23-positive, CD62L-positive, and CD93-positive. This cell type has also been described as IgM-low, CD19-positive, B220-positive, AA4-positive, and CD23-positive (i.e. this cell-type is distinguished from T2 cells by surface expression of IgM)." [GO_REF:0000031, GOC:msz, GOC:tfm, http://www.immgen.org/index_content.html, PMID:12810111, PMID:17174121] subset: human_subset subset: mouse_subset synonym: "An1 B cell" EXACT [PMID:17174121] synonym: "T3 B lymphocyte" EXACT [] synonym: "T3 B-cell" EXACT [] synonym: "T3 B-lymphocyte" EXACT [] synonym: "transitional stage 3 B cell" EXACT [] is_a: CL:0000818 {is_inferred="true"} ! transitional stage B cell intersection_of: CL:0000818 ! transitional stage B cell intersection_of: RO:0000056 GO:0002515 ! participates in B cell anergy intersection_of: RO:0002104 GO:0071738 ! has plasma membrane part IgD immunoglobulin complex intersection_of: RO:0002104 GO:0071753 ! has plasma membrane part IgM immunoglobulin complex intersection_of: RO:0002104 PR:000001318 ! has plasma membrane part L-selectin intersection_of: RO:0002104 PR:000001338 ! has plasma membrane part complement receptor type 2 intersection_of: RO:0002104 PR:000001880 ! has plasma membrane part low affinity immunoglobulin epsilon Fc receptor relationship: RO:0000056 GO:0002515 ! participates in B cell anergy relationship: RO:0002104 GO:0071738 ! has plasma membrane part IgD immunoglobulin complex relationship: RO:0002104 PR:000001318 ! has plasma membrane part L-selectin relationship: RO:0002104 PR:000001338 ! has plasma membrane part complement receptor type 2 relationship: RO:0002104 PR:000001880 ! has plasma membrane part low affinity immunoglobulin epsilon Fc receptor relationship: RO:0002202 CL:0000959 ! develops from T2 B cell [Term] id: CL:0000961 name: Bm1 B cell def: "A follicular B cell that is IgD-positive, CD23-negative, and CD38-negative. This naive cell type is activated in the extrafollicular areas through interaction with interdigitating dendritic cells and antigen-specific CD4-positive T cells." [GO_REF:0000031, GOC:dsd, GOC:msz, PMID:11564773, PMID:17992590, PMID:18432934, PMID:19350211, PMID:31681331, PMID:8006591] comment: These cells are also reportedly CD10-negative, CD39-positive, CD44-positive, CD71-negative, CD77-negative, IgM-positive, IgG-negative, IgA-negative, and IgE-negative. subset: human_subset synonym: "Bm1 B lymphocyte" EXACT [] synonym: "Bm1 B-cell" EXACT [] synonym: "Bm1 B-lymphocyte" EXACT [] is_a: CL:0000843 {is_inferred="true"} ! follicular B cell intersection_of: CL:0000843 ! follicular B cell intersection_of: CL:4030046 PR:000001408 ! lacks_plasma_membrane_part ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 intersection_of: CL:4030046 PR:000001880 ! lacks_plasma_membrane_part low affinity immunoglobulin epsilon Fc receptor intersection_of: RO:0002104 GO:0071738 ! has plasma membrane part IgD immunoglobulin complex intersection_of: RO:0002162 NCBITaxon:9606 ! in taxon Homo sapiens relationship: CL:4030046 PR:000001408 ! lacks_plasma_membrane_part ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 relationship: CL:4030046 PR:000001880 ! lacks_plasma_membrane_part low affinity immunoglobulin epsilon Fc receptor relationship: RO:0002162 NCBITaxon:9606 ! in taxon Homo sapiens [Term] id: CL:0000962 name: Bm2 B cell def: "A follicular B cell that is IgD-positive and CD23-positive and CD38-positive. This naive cell type is activated in the extrafollicular areas via interaction with dendritic cells and antigen specific T cells." [GO_REF:0000031, GOC:dsd, GOC:msz, PMID:11564773, PMID:17992590, PMID:18432934, PMID:19350211, PMID:31681331, PMID:8006591] comment: These cells are also CD10-negative, CD39-positive, CD44-positive, CD71-negative, CD77-negative, IgM-positive, IgG-negative, IgA-negative, and IgE-negative. subset: human_subset synonym: "Bm2 B lymphocyte" EXACT [] synonym: "Bm2 B-cell" EXACT [] synonym: "Bm2 B-lymphocyte" EXACT [] is_a: CL:0000843 {is_inferred="true"} ! follicular B cell intersection_of: CL:0000843 ! follicular B cell intersection_of: RO:0002104 GO:0071738 ! has plasma membrane part IgD immunoglobulin complex intersection_of: RO:0002104 PR:000001408 ! has plasma membrane part ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 intersection_of: RO:0002104 PR:000001880 ! has plasma membrane part low affinity immunoglobulin epsilon Fc receptor intersection_of: RO:0002162 NCBITaxon:9606 ! in taxon Homo sapiens relationship: RO:0002104 PR:000001408 ! has plasma membrane part ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 relationship: RO:0002104 PR:000001880 ! has plasma membrane part low affinity immunoglobulin epsilon Fc receptor relationship: RO:0002202 CL:0000961 ! develops from Bm1 B cell [Term] id: CL:0000963 name: Bm3-delta B cell def: "A germinal center B cell that develops from a Bm3 B cell. This cell has the phenotype IgM-negative, IgD-positive, and CD38-positive." [GO_REF:0000031, GOC:add, GOC:msz, GOC:tfm, PMID:9280752] subset: human_subset synonym: "Bm3-delta B lymphocyte" EXACT [] synonym: "Bm3-delta B-cell" EXACT [] synonym: "Bm3-delta B-lymphocyte" EXACT [] is_a: CL:0000844 {is_inferred="true"} ! germinal center B cell intersection_of: CL:0000844 ! germinal center B cell intersection_of: CL:4030046 GO:0071753 ! lacks_plasma_membrane_part IgM immunoglobulin complex intersection_of: RO:0002104 GO:0071738 ! has plasma membrane part IgD immunoglobulin complex intersection_of: RO:0002104 PR:000001408 ! has plasma membrane part ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 relationship: CL:4030046 GO:0071753 ! lacks_plasma_membrane_part IgM immunoglobulin complex relationship: RO:0002104 GO:0071738 ! has plasma membrane part IgD immunoglobulin complex relationship: RO:0002104 PR:000001408 ! has plasma membrane part ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 relationship: RO:0002202 CL:0000965 ! develops from Bm3 B cell [Term] id: CL:0000964 name: Bm2' B cell def: "A germinal center B cell that founds a germinal center, and has the phenotype IgD-positive, CD38-positive, and CD23-negative." [GO_REF:0000031, GOC:dsd, GOC:msz, GOC:tfm, PMID:11564773, PMID:17992590, PMID:18432934, PMID:19350211, PMID:31681331, PMID:8006591] comment: Bm2' B cells are also reportedly CD10-positive, CD39-negative, CD44-negative, CD71-positive, CD77-negative, IgM-positive, IgG-negative, IgA-negative, and IgE-negative. subset: human_subset synonym: "Bm2' B lymphocyte" EXACT [] synonym: "Bm2' B-cell" EXACT [] synonym: "Bm2-prime B cell" EXACT [] synonym: "Bm2-prime B-lymphocyte" EXACT [] synonym: "germinal center founder cell" RELATED [] is_a: CL:0000844 {is_inferred="true"} ! germinal center B cell intersection_of: CL:0000844 ! germinal center B cell intersection_of: CL:4030046 PR:000001880 ! lacks_plasma_membrane_part low affinity immunoglobulin epsilon Fc receptor intersection_of: RO:0002104 GO:0071738 ! has plasma membrane part IgD immunoglobulin complex intersection_of: RO:0002104 PR:000001408 ! has plasma membrane part ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 intersection_of: RO:0002162 NCBITaxon:9606 ! in taxon Homo sapiens intersection_of: RO:0002215 GO:0002634 ! capable of regulation of germinal center formation relationship: CL:4030046 PR:000001880 ! lacks_plasma_membrane_part low affinity immunoglobulin epsilon Fc receptor relationship: RO:0002104 GO:0071738 ! has plasma membrane part IgD immunoglobulin complex relationship: RO:0002104 PR:000001408 ! has plasma membrane part ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 relationship: RO:0002202 CL:0000962 ! develops from Bm2 B cell relationship: RO:0002215 GO:0002634 ! capable of regulation of germinal center formation [Term] id: CL:0000965 name: Bm3 B cell def: "A germinal center B cell that is rapidly dividing and has the phenotype IgD-negative, CD38-positive, and CD77-positive. Somatic hypermutation of the immunoglobulin V gene region can occur during proliferation of this cell type." [GO_REF:0000031, GOC:dsd, GOC:msz, PMID:11564773, PMID:18432934, PMID:19350211, PMID:31681331, PMID:8006591] comment: Bm3 B cells are also reportedly CD10-positive, CD23-negative, CD39-negative, CD44-negative, CD71-positive, and CD77-positive. subset: human_subset synonym: "Bm3 B lymphocyte" EXACT [] synonym: "Bm3 B-cell" EXACT [] synonym: "Bm3 B-lymphocyte" EXACT [] synonym: "centroblast" RELATED [PMID:8006591] is_a: CL:0000844 {is_inferred="true"} ! germinal center B cell intersection_of: CL:0000844 ! germinal center B cell intersection_of: CL:4030046 GO:0071738 ! lacks_plasma_membrane_part IgD immunoglobulin complex intersection_of: RO:0002104 PR:000001408 ! has plasma membrane part ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 intersection_of: RO:0002104 PR:000003516 ! has plasma membrane part lactosylceramide 4-alpha-galactosyltransferase intersection_of: RO:0002162 NCBITaxon:9606 ! in taxon Homo sapiens intersection_of: RO:0002215 GO:0016446 ! capable of somatic hypermutation of immunoglobulin genes relationship: CL:4030046 GO:0071738 ! lacks_plasma_membrane_part IgD immunoglobulin complex relationship: RO:0002104 PR:000001408 ! has plasma membrane part ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 relationship: RO:0002104 PR:000003516 ! has plasma membrane part lactosylceramide 4-alpha-galactosyltransferase relationship: RO:0002202 CL:0000964 ! develops from Bm2' B cell relationship: RO:0002215 GO:0016446 ! capable of somatic hypermutation of immunoglobulin genes [Term] id: CL:0000966 name: Bm4 B cell def: "A germinal center B cell that has the phenotype CD77-negative, IgD-negative, and CD38-positive. These cells have undergone somatic mutation of the B cell receptor." [GO_REF:0000031, GOC:dsd, GOC:msz, PMID:11564773, PMID:18432934, PMID:19350211, PMID:31681331, PMID:8006591] comment: Bm4 B cells are also reportedly CD10-positive, CD23-negative, CD39-negative, CD44-positive, and CD71-positive. subset: human_subset synonym: "Bm4 B lymphocyte" EXACT [] synonym: "Bm4 B-cell" EXACT [] synonym: "Bm4 B-lymphocyte" EXACT [] synonym: "centrocyte" RELATED [PMID:17992590] is_a: CL:0000844 {is_inferred="true"} ! germinal center B cell intersection_of: CL:0000844 ! germinal center B cell intersection_of: CL:4030046 GO:0071738 ! lacks_plasma_membrane_part IgD immunoglobulin complex intersection_of: CL:4030046 PR:000003516 ! lacks_plasma_membrane_part lactosylceramide 4-alpha-galactosyltransferase intersection_of: RO:0002104 PR:000001408 ! has plasma membrane part ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 intersection_of: RO:0002162 NCBITaxon:9606 ! in taxon Homo sapiens intersection_of: RO:0002353 GO:0016446 ! output of somatic hypermutation of immunoglobulin genes relationship: CL:4030046 GO:0071738 ! lacks_plasma_membrane_part IgD immunoglobulin complex relationship: CL:4030046 PR:000003516 ! lacks_plasma_membrane_part lactosylceramide 4-alpha-galactosyltransferase relationship: RO:0002104 PR:000001408 ! has plasma membrane part ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 relationship: RO:0002202 CL:0000963 ! develops from Bm3-delta B cell relationship: RO:0002353 GO:0016446 ! output of somatic hypermutation of immunoglobulin genes [Term] id: CL:0000967 name: Bm5 B cell def: "A memory B cell arising in the germinal center that is IgD-negative and has undergone somatic mutation of the variable region of the immunoglobulin heavy and light chain genes." [GO_REF:0000031, GOC:dsd, GOC:msz, GOC:tfm, PMID:11564773, PMID:18432934, PMID:19350211, PMID:31681331, PMID:8006591] comment: Bm5 B cells are also reportedly CD10-positive, CD23-negative, CD38-negative, CD39-positive, CD44-positive, CD71-positive, and CD77-negative. subset: human_subset synonym: "Bm5 B lymphocyte" EXACT [] synonym: "Bm5 B-cell" EXACT [] synonym: "Bm5 B-lymphocyte" EXACT [] is_a: CL:0001053 ! IgD-negative memory B cell intersection_of: CL:0000787 ! memory B cell intersection_of: CL:4030046 GO:0071738 ! lacks_plasma_membrane_part IgD immunoglobulin complex intersection_of: RO:0002162 NCBITaxon:9606 ! in taxon Homo sapiens intersection_of: RO:0002353 GO:0002314 ! output of germinal center B cell differentiation intersection_of: RO:0002353 GO:0016446 ! output of somatic hypermutation of immunoglobulin genes relationship: RO:0002202 CL:0000966 ! develops from Bm4 B cell relationship: RO:0002353 GO:0002314 ! output of germinal center B cell differentiation relationship: RO:0002353 GO:0016446 ! output of somatic hypermutation of immunoglobulin genes [Term] id: CL:0000968 name: Be cell def: "A mature B cell that produces cytokines that can influence CD4 T cell differentiation." [GO_REF:0000031, GOC:msz, GOC:tfm, PMID:11101868, PMID:20224569] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "B effector cell" EXACT [] synonym: "effector B cell" EXACT [] synonym: "effector B lymphocyte" EXACT [] synonym: "effector B-cell" EXACT [] synonym: "effector B-lymphocyte" EXACT [] is_a: CL:0000785 {is_inferred="true"} ! mature B cell intersection_of: CL:0000785 ! mature B cell intersection_of: RO:0002104 PR:000001289 ! has plasma membrane part membrane-spanning 4-domains subfamily A member 1 intersection_of: RO:0002215 GO:0001816 ! capable of cytokine production intersection_of: RO:0002215 GO:0043370 ! capable of regulation of CD4-positive, alpha-beta T cell differentiation relationship: RO:0002104 PR:000001289 ! has plasma membrane part membrane-spanning 4-domains subfamily A member 1 relationship: RO:0002215 GO:0001816 ! capable of cytokine production relationship: RO:0002215 GO:0043370 ! capable of regulation of CD4-positive, alpha-beta T cell differentiation [Term] id: CL:0000969 name: regulatory B cell def: "A mature B cell that has the phenotype CD1d-positive and expresses interleukin-10. This cell type has been associated with suppression of chronic inflammatory responses and T cell responses." [GO_REF:0000031, GOC:dsd, GOC:msz, GOC:tfm, MESH:D060151, PMID:11869683, PMID:18482568, PMID:20224569, PMID:20809522] comment: Regulatory B cells reportedly represent 1-2% of the spleen and 7-8% of the peritoneal B220-positive cells in mice. They are also found in the bone marrow, lymph node, and blood of mice. These cells are also reportedly capable of secreting IL-10 and are reportedly CD5-positive, CD21-positive, CD24-positive, CD93-negative, B220-positive, IgM-positive, and IgD-positive. subset: human_subset subset: mouse_subset synonym: "B(reg)" EXACT [] synonym: "B10 cell" EXACT [] synonym: "Breg" EXACT [] synonym: "regulatory B lymphocyte" EXACT [] synonym: "regulatory B-cell" EXACT [] synonym: "regulatory B-lymphocyte" EXACT [] is_a: CL:0000785 {is_inferred="true"} ! mature B cell intersection_of: CL:0000785 ! mature B cell intersection_of: RO:0002104 PR:000001289 ! has plasma membrane part membrane-spanning 4-domains subfamily A member 1 intersection_of: RO:0002104 PR:000002028 ! has plasma membrane part antigen-presenting glycoprotein CD1d intersection_of: RO:0002215 GO:0032613 ! capable of interleukin-10 production intersection_of: RO:0002215 GO:0050777 ! capable of negative regulation of immune response relationship: RO:0002104 PR:000001289 ! has plasma membrane part membrane-spanning 4-domains subfamily A member 1 relationship: RO:0002104 PR:000002028 ! has plasma membrane part antigen-presenting glycoprotein CD1d relationship: RO:0002215 GO:0032613 ! capable of interleukin-10 production relationship: RO:0002215 GO:0050777 ! capable of negative regulation of immune response [Term] id: CL:0000970 name: unswitched memory B cell def: "An unswitched memory B cell is a memory B cell that has the phenotype IgM-positive, IgD-positive, CD27-positive, CD138-negative, IgG-negative, IgE-negative, and IgA-negative." [GO_REF:0000031, GOC:add, GOC:dsd, GOC:rhs, ISBN:0781765196, PMID:20933013, PMID:22343568] comment: This cell type is compatible with the HIPC Lyoplate markers for 'IgD+ memory B cell'. Per DSD: Unswitched memory B cells are also reportedly CD48-positive, CD84-positive, CD229-positive, and CD352-positive. subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "IgD+ memory B cell" BROAD [PMID:22343568] synonym: "non-class-switched memory B cell" EXACT [HP:0032126] synonym: "unswitched memory B lymphocyte" EXACT [] synonym: "unswitched memory B-cell" EXACT [] synonym: "unswitched memory B-lymphocyte" EXACT [] is_a: CL:0000787 {is_inferred="true"} ! memory B cell intersection_of: CL:0000787 ! memory B cell intersection_of: CL:4030046 GO:0071735 ! lacks_plasma_membrane_part IgG immunoglobulin complex intersection_of: CL:4030046 GO:0071742 ! lacks_plasma_membrane_part IgE immunoglobulin complex intersection_of: CL:4030046 GO:0071745 ! lacks_plasma_membrane_part IgA immunoglobulin complex intersection_of: CL:4030046 PR:000001935 ! lacks_plasma_membrane_part syndecan-1 intersection_of: RO:0002104 GO:0071738 ! has plasma membrane part IgD immunoglobulin complex intersection_of: RO:0002104 GO:0071753 ! has plasma membrane part IgM immunoglobulin complex intersection_of: RO:0002104 PR:000001963 ! has plasma membrane part CD27 molecule relationship: CL:4030046 GO:0071735 ! lacks_plasma_membrane_part IgG immunoglobulin complex relationship: CL:4030046 GO:0071742 ! lacks_plasma_membrane_part IgE immunoglobulin complex relationship: CL:4030046 GO:0071745 ! lacks_plasma_membrane_part IgA immunoglobulin complex relationship: RO:0002104 GO:0071738 ! has plasma membrane part IgD immunoglobulin complex relationship: RO:0002104 GO:0071753 ! has plasma membrane part IgM immunoglobulin complex relationship: RO:0002104 PR:000001963 ! has plasma membrane part CD27 molecule relationship: RO:0002202 CL:0000980 ! develops from plasmablast property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0000971 name: IgM memory B cell def: "An IgM memory B cell is an unswitched memory B cell with the phenotype IgM-positive and IgD-negative." [GO_REF:0000031, GOC:dsd, GOC:rhs, ISBN:0781765196, PMID:19447676] comment: IgM memory B cells are also reportedly CD1c-positive, CD95-positive, CD80-positive, CD84-positive, CD86-positive, CD150-negative, CD229-positive, CD289-positive, and CD290-positive. Transcription factors: Notch2-positive, PAX5-positive, SpiB-positive, Ets1-positive, and OBF1-positive. subset: human_subset subset: mouse_subset synonym: "IgM memory B lymphocyte" EXACT [] synonym: "IgM memory B-cell" EXACT [] synonym: "IgM memory B-lymphocyte" EXACT [] synonym: "memory IgM B cell" EXACT [] synonym: "memory IgM B lymphocyte" EXACT [] synonym: "memory IgM B-cell" EXACT [] synonym: "memory IgM B-lymphocyte" EXACT [] is_a: CL:0001053 ! IgD-negative memory B cell intersection_of: CL:0000787 ! memory B cell intersection_of: CL:4030046 GO:0071738 ! lacks_plasma_membrane_part IgD immunoglobulin complex intersection_of: RO:0002104 GO:0071753 ! has plasma membrane part IgM immunoglobulin complex relationship: RO:0002104 GO:0071753 ! has plasma membrane part IgM immunoglobulin complex [Term] id: CL:0000972 name: class switched memory B cell def: "A class switched memory B cell is a memory B cell that has undergone Ig class switching and therefore is IgM-negative on the cell surface. These cells are CD27-positive and have either IgG, IgE, or IgA on the cell surface." [GO_REF:0000031, GOC:add, GOC:dsd, GOC:rhs, ISBN:0781765196, PMID:20933013, PMID:9295047] comment: Per DSD: Class switched memory B cells are also reportedly CD48-positive, CD229-positive, and CD352-positive. subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "class switched memory B lymphocyte" EXACT [] synonym: "class switched memory B-cell" EXACT [] synonym: "class switched memory B-lymphocyte" EXACT [] is_a: CL:0000787 {is_inferred="true"} ! memory B cell intersection_of: CL:0000787 ! memory B cell intersection_of: CL:4030046 GO:0071753 ! lacks_plasma_membrane_part IgM immunoglobulin complex intersection_of: RO:0002104 PR:000001963 ! has plasma membrane part CD27 molecule intersection_of: RO:0002353 GO:0045190 ! output of isotype switching relationship: CL:4030046 GO:0071753 ! lacks_plasma_membrane_part IgM immunoglobulin complex relationship: RO:0002104 PR:000001963 ! has plasma membrane part CD27 molecule relationship: RO:0002202 CL:0000970 ! develops from unswitched memory B cell relationship: RO:0002353 GO:0045190 ! output of isotype switching property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0000973 name: IgA memory B cell def: "A class switched memory B cell that expresses IgA." [GO_REF:0000031, GOC:dsd, GOC:msz, ISBN:0781765196] comment: IgA memory B cell are also reportedly RORalpha-positive. subset: human_subset subset: mouse_subset synonym: "IgA memory B lymphocyte" EXACT [] synonym: "IgA memory B-cell" EXACT [] synonym: "IgA memory B-lymphocyte" EXACT [] synonym: "memory IgA B cell" EXACT [] synonym: "memory IgA B lymphocyte" EXACT [] synonym: "memory IgA B-cell" EXACT [] synonym: "memory IgA B-lymphocyte" EXACT [] is_a: CL:4052108 ! IgD-negative class switched memory B cell intersection_of: CL:0000972 ! class switched memory B cell intersection_of: RO:0002104 GO:0071745 ! has plasma membrane part IgA immunoglobulin complex relationship: RO:0002104 GO:0071745 ! has plasma membrane part IgA immunoglobulin complex [Term] id: CL:0000974 name: long lived plasma cell def: "A fully differentiated plasma cell that lives for years, as opposed to months, secretes immunoglobulin, and has the phenotype weakly CD19-positive, CD20-negative, CD38-negative, strongly CD138-positive, MHC Class II-negative, surface immunoglobulin-negative, IgD-negative, and strongly CXCR4-positive. The majority of these cells of this type reside in the bone marrow." [GO_REF:0000031, GOC:msz, GOC:tfm, ISBN:9780781765190, PMID:16014527] subset: human_subset subset: mouse_subset is_a: CL:0000786 {is_inferred="true"} ! plasma cell intersection_of: CL:0000786 ! plasma cell intersection_of: CL:4030046 GO:0019814 ! lacks_plasma_membrane_part immunoglobulin complex intersection_of: CL:4030046 GO:0042613 ! lacks_plasma_membrane_part MHC class II protein complex intersection_of: CL:4030046 PR:000001289 ! lacks_plasma_membrane_part membrane-spanning 4-domains subfamily A member 1 intersection_of: CL:4030046 PR:000001408 ! lacks_plasma_membrane_part ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 intersection_of: RO:0015015 PR:000001208 ! has high plasma membrane amount C-X-C chemokine receptor type 4 intersection_of: RO:0015015 PR:000001935 ! has high plasma membrane amount syndecan-1 intersection_of: RO:0015016 PR:000001002 ! has low plasma membrane amount CD19 molecule relationship: CL:4030046 PR:000001408 ! lacks_plasma_membrane_part ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 relationship: RO:0002202 CL:0000975 ! develops from short lived plasma cell relationship: RO:0015015 PR:000001208 ! has high plasma membrane amount C-X-C chemokine receptor type 4 relationship: RO:0015015 PR:000001935 ! has high plasma membrane amount syndecan-1 relationship: RO:0015016 PR:000001002 ! has low plasma membrane amount CD19 molecule [Term] id: CL:0000975 name: short lived plasma cell def: "A fully differentiated plasma cell that lives for months." [GO_REF:0000031, GOC:msz, PMID:16014527] subset: human_subset subset: mouse_subset is_a: CL:0000786 {is_inferred="true"} ! plasma cell intersection_of: CL:0000786 ! plasma cell intersection_of: RO:0000053 PATO:0001604 ! has characteristic decreased life span relationship: RO:0000053 PATO:0001604 ! has characteristic decreased life span [Term] id: CL:0000976 name: IgA short lived plasma cell def: "A short lived plasma cell that secretes IgA. These cells may be found in the bone marrow as well as in the mucosal immune system." [GO_REF:0000031, GOC:msz, ISBN:781735149] subset: human_subset subset: mouse_subset is_a: CL:0000975 {is_inferred="true"} ! short lived plasma cell intersection_of: CL:0000975 ! short lived plasma cell intersection_of: RO:0003000 GO:0071746 ! produces IgA immunoglobulin complex, circulating relationship: RO:0003000 GO:0071746 ! produces IgA immunoglobulin complex, circulating [Term] id: CL:0000977 name: IgG short lived plasma cell def: "A short lived plasma cell that secretes IgG." [GO_REF:0000031, GOC:msz, ISBN:781735149] subset: human_subset subset: mouse_subset is_a: CL:0000975 {is_inferred="true"} ! short lived plasma cell intersection_of: CL:0000975 ! short lived plasma cell intersection_of: RO:0003000 GO:0071736 ! produces IgG immunoglobulin complex, circulating relationship: RO:0003000 GO:0071736 ! produces IgG immunoglobulin complex, circulating [Term] id: CL:0000978 name: IgM short lived plasma cell def: "A short lived plasma cell that secretes IgM." [GO_REF:0000031, GOC:msz, ISBN:781735149] subset: human_subset subset: mouse_subset is_a: CL:0000975 {is_inferred="true"} ! short lived plasma cell intersection_of: CL:0000975 ! short lived plasma cell intersection_of: RO:0003000 GO:0071754 ! produces IgM immunoglobulin complex, circulating relationship: RO:0003000 GO:0071754 ! produces IgM immunoglobulin complex, circulating [Term] id: CL:0000979 name: IgG memory B cell def: "An IgG memory B cell is a class switched memory B cell that is class switched and expresses IgG on the cell surface." [GO_REF:0000031, GOC:rhs, ISBN:0781765196] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "IgG memory B lymphocyte" EXACT [] synonym: "IgG memory B-cell" EXACT [] synonym: "IgG memory B-lymphocyte" EXACT [] synonym: "memory IgG B cell" EXACT [] synonym: "memory IgG B lymphocyte" EXACT [] synonym: "memory IgG B-cell" EXACT [] synonym: "memory IgG B-lymphocyte" EXACT [] is_a: CL:0000972 {is_inferred="true"} ! class switched memory B cell intersection_of: CL:0000972 ! class switched memory B cell intersection_of: RO:0002104 GO:0071735 ! has plasma membrane part IgG immunoglobulin complex relationship: RO:0002104 GO:0071735 ! has plasma membrane part IgG immunoglobulin complex [Term] id: CL:0000980 name: plasmablast def: "An activated mature (naive or memory) B cell that is secreting immunoglobulin, typified by being CD27-positive, CD38-positive, CD138-negative." [GO_REF:0000031, GOC:dsd, GOC:msz, GOC:tfm, PMCID:PMC2673126] comment: This cell type is compatible with the HIPC Lyoplate markers for 'plasmablast'. Plasmablasts are also reportedly CD48-positive, CD63-positive, CD229-positive, CD270-positive, CD319-positive, CD352-positive, CD361-positive, and IgD-negative. subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "CD20-negative B cell" BROAD [] synonym: "CD27-positive, CD38-positive, CD20-negative B cell" EXACT [] xref: FMA:84371 is_a: CL:0000785 {is_inferred="true"} ! mature B cell is_a: CL:0000946 ! antibody secreting cell intersection_of: CL:0000785 ! mature B cell intersection_of: CL:4030046 PR:000001289 ! lacks_plasma_membrane_part membrane-spanning 4-domains subfamily A member 1 intersection_of: CL:4030046 PR:000001935 ! lacks_plasma_membrane_part syndecan-1 intersection_of: RO:0003000 GO:0042571 ! produces immunoglobulin complex, circulating intersection_of: RO:0015015 PR:000001408 ! has high plasma membrane amount ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 intersection_of: RO:0015015 PR:000001963 ! has high plasma membrane amount CD27 molecule relationship: CL:4030046 PR:000001289 ! lacks_plasma_membrane_part membrane-spanning 4-domains subfamily A member 1 relationship: CL:4030046 PR:000001935 ! lacks_plasma_membrane_part syndecan-1 relationship: RO:0002202 CL:0000785 ! develops from mature B cell relationship: RO:0015015 PR:000001408 ! has high plasma membrane amount ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 relationship: RO:0015015 PR:000001963 ! has high plasma membrane amount CD27 molecule property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0000981 name: double negative memory B cell def: "A memory B cell with the phenotype IgD-negative and CD27-negative." [GO_REF:0000031, GOC:msz, GOC:tfm] subset: human_subset subset: mouse_subset synonym: "dn memory B cell" EXACT [] synonym: "dn memory B lymphocyte" EXACT [] synonym: "dn memory B-cell" EXACT [] synonym: "dn memory B-lymphocyte" EXACT [] synonym: "double negative memory B lymphocyte" EXACT [] synonym: "double negative memory B-cell" EXACT [] synonym: "double negative memory B-lymphocyte" EXACT [] is_a: CL:0001053 ! IgD-negative memory B cell intersection_of: CL:0000787 ! memory B cell intersection_of: CL:4030046 GO:0071738 ! lacks_plasma_membrane_part IgD immunoglobulin complex intersection_of: CL:4030046 PR:000001963 ! lacks_plasma_membrane_part CD27 molecule relationship: CL:4030046 PR:000001963 ! lacks_plasma_membrane_part CD27 molecule [Term] id: CL:0000982 name: IgG plasmablast def: "A plasmablast that secretes IgG." [GO_REF:0000031, GOC:msz] subset: cellxgene_subset subset: human_subset subset: mouse_subset is_a: CL:0000980 {is_inferred="true"} ! plasmablast intersection_of: CL:0000980 ! plasmablast intersection_of: RO:0003000 GO:0071736 ! produces IgG immunoglobulin complex, circulating relationship: RO:0003000 GO:0071736 ! produces IgG immunoglobulin complex, circulating [Term] id: CL:0000983 name: IgM plasmablast def: "A plasmablast that secretes IgM." [GO_REF:0000031, GOC:msz] subset: cellxgene_subset subset: human_subset subset: mouse_subset is_a: CL:0000980 {is_inferred="true"} ! plasmablast intersection_of: CL:0000980 ! plasmablast intersection_of: RO:0003000 GO:0071754 ! produces IgM immunoglobulin complex, circulating relationship: RO:0003000 GO:0071754 ! produces IgM immunoglobulin complex, circulating [Term] id: CL:0000984 name: IgA plasmablast def: "A plasmablast that secretes IgA." [GO_REF:0000031, GOC:msz] subset: cellxgene_subset subset: human_subset subset: mouse_subset is_a: CL:0000980 {is_inferred="true"} ! plasmablast intersection_of: CL:0000980 ! plasmablast intersection_of: RO:0003000 GO:0071746 ! produces IgA immunoglobulin complex, circulating relationship: RO:0003000 GO:0071746 ! produces IgA immunoglobulin complex, circulating [Term] id: CL:0000985 name: IgG plasma cell def: "A fully differentiated plasma cell that secretes IgG." [GO_REF:0000031, GOC:msz, ISBN:781735149] subset: cellxgene_subset subset: human_subset subset: mouse_subset is_a: CL:0000974 {is_inferred="true"} ! long lived plasma cell intersection_of: CL:0000974 ! long lived plasma cell intersection_of: RO:0003000 GO:0071736 ! produces IgG immunoglobulin complex, circulating relationship: RO:0003000 GO:0071736 ! produces IgG immunoglobulin complex, circulating [Term] id: CL:0000986 name: IgM plasma cell def: "A fully differentiated plasma cell that secretes IgM." [GO_REF:0000031, GOC:msz, ISBN:781735149] subset: cellxgene_subset subset: human_subset subset: mouse_subset is_a: CL:0000974 {is_inferred="true"} ! long lived plasma cell intersection_of: CL:0000974 ! long lived plasma cell intersection_of: RO:0003000 GO:0071754 ! produces IgM immunoglobulin complex, circulating relationship: RO:0003000 GO:0071754 ! produces IgM immunoglobulin complex, circulating [Term] id: CL:0000987 name: IgA plasma cell def: "A fully differentiated plasma cell that secretes IgA." [GO_REF:0000031, GOC:msz, ISBN:781735149] subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset is_a: CL:0000974 {is_inferred="true"} ! long lived plasma cell intersection_of: CL:0000974 ! long lived plasma cell intersection_of: RO:0003000 GO:0071746 ! produces IgA immunoglobulin complex, circulating relationship: RO:0003000 GO:0071746 ! produces IgA immunoglobulin complex, circulating property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0000988 name: hematopoietic cell def: "A cell of a hematopoietic lineage." [GO_REF:0000031, GOC:add] subset: cellxgene_subset subset: general_cell_types_upper_slim subset: human_subset subset: mouse_subset synonym: "haematopoietic cell" EXACT [] synonym: "haemopoietic cell" EXACT [] synonym: "hemopoietic cell" EXACT [] xref: BTO:0000574 xref: CALOHA:TS-2017 xref: FMA:70366 xref: FMA:83598 xref: ZFA:0005830 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000000 ! cell property_value: skos:prefLabel "hematopoietic cell" xsd:string [Term] id: CL:0000989 name: CD11c-low plasmacytoid dendritic cell def: "CD11c-low plasmacytoid dendritic cell is a leukocyte that is CD11c-low, CD45R-positive, GR1-positive and CD11b-negative." [GO_REF:0000031, GOC:amm, GOC:dsd, PMID:15771572, PMID:17850486, PMID:19243617, PMID:34603298] comment: Originally described in the dendritic cell ontology (DC_CL:0000001)(PMID:19243617). These cells are CD281-positive (TLR1), CD282-positive (TLR2), CD285-positive (TLR5), CD286-positive (TLR6), and CD288-positive (TLR8). subset: mouse_subset is_a: CL:0000784 {is_inferred="true"} ! plasmacytoid dendritic cell intersection_of: CL:0000784 ! plasmacytoid dendritic cell intersection_of: CL:4030046 PR:000001012 ! lacks_plasma_membrane_part integrin alpha-M intersection_of: RO:0002104 PR:000001014 ! has plasma membrane part receptor-type tyrosine-protein phosphatase C isoform CD45RABC intersection_of: RO:0002104 PR:000002978 ! has plasma membrane part lymphocyte antigen 6G intersection_of: RO:0015016 PR:000001013 ! has low plasma membrane amount integrin alpha-X relationship: CL:4030046 PR:000001012 ! lacks_plasma_membrane_part integrin alpha-M relationship: RO:0002104 PR:000001014 ! has plasma membrane part receptor-type tyrosine-protein phosphatase C isoform CD45RABC relationship: RO:0002104 PR:000002978 ! has plasma membrane part lymphocyte antigen 6G relationship: RO:0002162 NCBITaxon:10090 ! in taxon Mus musculus relationship: RO:0015016 PR:000001013 ! has low plasma membrane amount integrin alpha-X [Term] id: CL:0000990 name: conventional dendritic cell def: "Conventional dendritic cell is a dendritic cell that is CD11c-high." [GO_REF:0000031, GOC:amm, PMID:17850486] comment: Originally described in the dendritic cell ontology (DC_CL:0000003)(PMID:19243617) These cells are also CD20-negative, MHCII-positive. subset: blood_and_immune_upper_slim subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "cDC" EXACT [] synonym: "DC1" EXACT [] synonym: "dendritic reticular cell" EXACT [] synonym: "interdigitating cell" BROAD [] synonym: "type 1 DC" EXACT [] synonym: "veiled cell" BROAD [] xref: FMA:84191 is_a: CL:0000451 {is_inferred="true"} ! dendritic cell intersection_of: CL:0000451 ! dendritic cell intersection_of: RO:0015015 PR:000001013 ! has high plasma membrane amount integrin alpha-X relationship: RO:0015015 PR:000001013 ! has high plasma membrane amount integrin alpha-X property_value: RO:0002175 NCBITaxon:9606 property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0000990" xsd:string {name="conventional dendritic cell on CELLxGENE CellGuide"} property_value: terms:description "Conventional dendritic cells (cDCs) are primarily responsible for processing antigens and presenting them to T cells to initiate an immune response. Also known as classical dendritic cells, cDCs originate from hematopoietic stem cells in the bone marrow, maturing in peripheral tissues. They are characterized by their distinct morphology, which features a central body with numerous branching extensions known as dendrites.\nThese cells have a pivotal role in adaptive immunity, bridging the gap between the innate and adaptive immune responses. They achieve this by capturing, processing, and presenting antigens to naive T-cells in the secondary lymphoid organs. This antigen presentation, in conjunction with co-stimulatory signals provided by the cDCs, instructs the T cells whether to mount an immune response against the antigen. cDCs are also very effective in the cross-presentation of antigens in the context of major histocompatibility complex (MHC) I, thereby activating CD8+ T cells an initiating a cytotoxic T cell response.\nIn addition to their role in antigen presentation, cDCs have other important functions in maintaining immune homeostasis. They can perceive signals from the surrounding tissue microenvironment, responding to inflammation, and influencing or even polarizing T cell differentiation into various effector subtypes. Importantly, while cDCs are often associated with immunogenic responses, they also play a crucial role in immune tolerance, particularly towards self-antigens, thereby preventing autoimmune reactions. In conclusion, conventional dendritic cells serve as the sentinels of the immune system, monitoring for threat signals and coordinating the appropriate immune response.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1016/bs.ircmb.2019.07.004", xref="DOI:10.1146/annurev-immunol-061020-053707", xref="DOI:10.3389/fimmu.2018.03176"} [Term] id: CL:0000991 name: CD11c-negative plasmacytoid dendritic cell def: "CD11c-negative plasmacytoid dendritic cell is a leukocyte is CD11c-negative, CD45RA-positive, CD85g-positive(ILT7), CD123-positive, CD303-positive." [GO_REF:0000031, GOC:amm, PMID:15771572, PMID:17850486, PMID:19243617, PMID:29313948] comment: Originally described in the dendritic cell ontology (DC_CL:0000004)(PMID:19243617). These cells are CD281-positive (TLR1), CD286-positive (TLR6), and CD290-positive (TLR10). subset: human_subset synonym: "CD303-positive dendritic cell" EXACT [] is_a: CL:0000784 {is_inferred="true"} ! plasmacytoid dendritic cell intersection_of: CL:0000784 ! plasmacytoid dendritic cell intersection_of: CL:4030046 PR:000001013 ! lacks_plasma_membrane_part integrin alpha-X intersection_of: RO:0002104 PR:000001014 ! has plasma membrane part receptor-type tyrosine-protein phosphatase C isoform CD45RABC intersection_of: RO:0002104 PR:000001292 ! has plasma membrane part C-type lectin domain family 4 member C intersection_of: RO:0002104 PR:000001398 ! has plasma membrane part leukocyte immunoglobulin-like receptor subfamily A member 4 intersection_of: RO:0002104 PR:000001865 ! has plasma membrane part interleukin-3 receptor class 2 alpha chain intersection_of: RO:0002215 GO:0001816 ! capable of cytokine production intersection_of: RO:0002215 GO:0032606 ! capable of type I interferon production relationship: CL:4030046 PR:000001013 ! lacks_plasma_membrane_part integrin alpha-X relationship: RO:0002104 PR:000001014 ! has plasma membrane part receptor-type tyrosine-protein phosphatase C isoform CD45RABC relationship: RO:0002104 PR:000001292 ! has plasma membrane part C-type lectin domain family 4 member C relationship: RO:0002104 PR:000001398 ! has plasma membrane part leukocyte immunoglobulin-like receptor subfamily A member 4 relationship: RO:0002104 PR:000001865 ! has plasma membrane part interleukin-3 receptor class 2 alpha chain relationship: RO:0002162 NCBITaxon:9606 ! in taxon Homo sapiens [Term] id: CL:0000992 name: immature CD11c-low plasmacytoid dendritic cell def: "Immature CD11c-low plasmacytoid dendritic cell is a CD11c-low plasmacytoid dendritic cell that is CD80-low and CD86-low." [GO_REF:0000031, GOC:amm, PMID:15771572, PMID:17850486] comment: Originally described in the dendritic cell ontology (DC_CL:0000006)(PMID:19243617). subset: mouse_subset is_a: CL:0000766 ! myeloid leukocyte is_a: CL:0000989 {is_inferred="true"} ! CD11c-low plasmacytoid dendritic cell intersection_of: CL:0000989 ! CD11c-low plasmacytoid dendritic cell intersection_of: RO:0015016 PR:000001412 ! has low plasma membrane amount CD86 molecule intersection_of: RO:0015016 PR:000001438 ! has low plasma membrane amount CD80 molecule relationship: RO:0002202 CL:0001029 ! develops from common dendritic progenitor relationship: RO:0015016 PR:000001412 ! has low plasma membrane amount CD86 molecule relationship: RO:0015016 PR:000001438 ! has low plasma membrane amount CD80 molecule [Term] id: CL:0000993 name: mature CD11c-low plasmacytoid dendritic cell def: "Mature CD11c-low plasmacytoid dendritic cell is a CD11c-low plasmacytoid dendritic cell that is CD83-high and is CD80-positive, CD86-positive, and MHCII-positive." [GO_REF:0000031, GOC:amm, PMID:15771572, PMID:17850486] comment: Originally described in the dendritic cell ontology (DC_CL:0000007)(PMID:19243617). subset: mouse_subset is_a: CL:0000766 ! myeloid leukocyte is_a: CL:0000989 {is_inferred="true"} ! CD11c-low plasmacytoid dendritic cell intersection_of: CL:0000989 ! CD11c-low plasmacytoid dendritic cell intersection_of: RO:0002104 PR:000001310 ! has plasma membrane part CD83 molecule intersection_of: RO:0015015 GO:0042613 ! has high plasma membrane amount MHC class II protein complex intersection_of: RO:0015015 PR:000001412 ! has high plasma membrane amount CD86 molecule intersection_of: RO:0015015 PR:000001438 ! has high plasma membrane amount CD80 molecule relationship: RO:0002104 PR:000001310 ! has plasma membrane part CD83 molecule relationship: RO:0002202 CL:0000992 ! develops from immature CD11c-low plasmacytoid dendritic cell relationship: RO:0015015 GO:0042613 ! has high plasma membrane amount MHC class II protein complex relationship: RO:0015015 PR:000001412 ! has high plasma membrane amount CD86 molecule relationship: RO:0015015 PR:000001438 ! has high plasma membrane amount CD80 molecule [Term] id: CL:0000994 name: immature CD11c-negative plasmacytoid dendritic cell def: "Immature CD11c-negative plasmacytoid dendritic cell is a CD11c-negative plasmacytoid dendritic cell is CD80-negative, CD86-low and MHCII-low." [GO_REF:0000031, GOC:amm, PMID:15771572, PMID:17850486] comment: Originally described in the dendritic cell ontology (DC_CL:0000008)(PMID:19243617). subset: human_subset is_a: CL:0000991 {is_inferred="true"} ! CD11c-negative plasmacytoid dendritic cell intersection_of: CL:0000991 ! CD11c-negative plasmacytoid dendritic cell intersection_of: CL:4030046 PR:000001438 ! lacks_plasma_membrane_part CD80 molecule intersection_of: RO:0002215 GO:0019882 ! capable of antigen processing and presentation intersection_of: RO:0015016 GO:0042613 ! has low plasma membrane amount MHC class II protein complex intersection_of: RO:0015016 PR:000001412 ! has low plasma membrane amount CD86 molecule relationship: CL:4030046 PR:000001438 ! lacks_plasma_membrane_part CD80 molecule relationship: RO:0002202 CL:0000995 ! develops from CD34-positive, CD38-positive common myeloid progenitor OR CD34-positive, CD38-positive common lymphoid progenitor relationship: RO:0015016 GO:0042613 ! has low plasma membrane amount MHC class II protein complex relationship: RO:0015016 PR:000001412 ! has low plasma membrane amount CD86 molecule [Term] id: CL:0000995 name: CD34-positive, CD38-positive common myeloid progenitor OR CD34-positive, CD38-positive common lymphoid progenitor comment: Originally described in the dendritic cell ontology (DC_CL:1100000)(PMID:19243617). subset: human_subset subset: mouse_subset synonym: "CD71-positive common myeloid precursor OR CD7-negative lymphoid precursor OR CD7-positive lymphoid" BROAD [] is_a: CL:0001060 ! hematopoietic oligopotent progenitor cell, lineage-negative is_a: CL:0011026 ! progenitor cell union_of: CL:0001021 ! CD34-positive, CD38-positive common lymphoid progenitor union_of: CL:0001026 ! CD34-positive, CD38-positive common myeloid progenitor [Term] id: CL:0000996 name: mature CD11c-negative plasmacytoid dendritic cell def: "Mature CD11c-negative plasmacytoid dendritic cell is a CD11c-negative plasmacytoid dendritic cell is CD80-high, CD86-high, MHCII-high and is CD83-positive." [GO_REF:0000031, GOC:amm, PMID:15771572, PMID:17850486] comment: Originally described in the dendritic cell ontology (DC_CL:0000009)(PMID:19243617). subset: human_subset is_a: CL:0000991 {is_inferred="true"} ! CD11c-negative plasmacytoid dendritic cell intersection_of: CL:0000991 ! CD11c-negative plasmacytoid dendritic cell intersection_of: RO:0002104 PR:000001310 ! has plasma membrane part CD83 molecule intersection_of: RO:0015015 GO:0042613 ! has high plasma membrane amount MHC class II protein complex intersection_of: RO:0015015 PR:000001412 ! has high plasma membrane amount CD86 molecule intersection_of: RO:0015015 PR:000001438 ! has high plasma membrane amount CD80 molecule relationship: RO:0002104 PR:000001310 ! has plasma membrane part CD83 molecule relationship: RO:0002202 CL:0000994 ! develops from immature CD11c-negative plasmacytoid dendritic cell relationship: RO:0015015 GO:0042613 ! has high plasma membrane amount MHC class II protein complex relationship: RO:0015015 PR:000001412 ! has high plasma membrane amount CD86 molecule relationship: RO:0015015 PR:000001438 ! has high plasma membrane amount CD80 molecule [Term] id: CL:0000997 name: immature CD8-alpha-negative CD11b-positive dendritic cell def: "Immature CD8-alpha-negative CD11b-positive dendritic cell is a CD8-alpha-negative CD11b-positive dendritic cell that is CD80-low, CD86-low, and MHCII-low." [GO_REF:0000031, GOC:amm, GOC:tfm, PMCID:PMC2346585] comment: Originally described in the dendritic cell ontology (DC_CL:0000010)(PMID:19243617). subset: human_subset subset: mouse_subset is_a: CL:0000840 ! immature conventional dendritic cell is_a: CL:0000999 {is_inferred="true"} ! CD4-positive CD11b-positive dendritic cell intersection_of: CL:0000999 ! CD4-positive CD11b-positive dendritic cell intersection_of: RO:0015016 GO:0042613 ! has low plasma membrane amount MHC class II protein complex intersection_of: RO:0015016 PR:000001412 ! has low plasma membrane amount CD86 molecule intersection_of: RO:0015016 PR:000001438 ! has low plasma membrane amount CD80 molecule [Term] id: CL:0000998 name: CD8-alpha-negative CD11b-negative dendritic cell def: "CD8-alpha-negative CD11b-negative dendritic cell is a conventional dendritic cell that is CD11b-negative, CD4-negative CD8-alpha-negative and is CD205-positive. This cell is able to cross- present antigen to CD8-alpha-positive T cells." [GO_REF:0000031, GOC:amm, http://www.immgen.org/index_content.html, PMCID:PMC2346585] comment: These markers are associated with mouse cells. Originally described in the dendritic cell ontology (DC_CL:0000011)(PMID:19243617). subset: human_subset subset: mouse_subset synonym: "DC.8-4-11b-" EXACT [] synonym: "triple negative dendritic cell" EXACT [] is_a: CL:0000766 ! myeloid leukocyte is_a: CL:0000990 {is_inferred="true"} ! conventional dendritic cell intersection_of: CL:0000990 ! conventional dendritic cell intersection_of: CL:4030046 PR:000001004 ! lacks_plasma_membrane_part CD4 molecule intersection_of: CL:4030046 PR:000001012 ! lacks_plasma_membrane_part integrin alpha-M intersection_of: CL:4030046 PR:000001084 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD8 alpha chain intersection_of: RO:0002104 PR:000001026 ! has plasma membrane part lymphocyte antigen 75 intersection_of: RO:0002215 GO:0002474 ! capable of antigen processing and presentation of peptide antigen via MHC class I relationship: CL:4030046 PR:000001004 ! lacks_plasma_membrane_part CD4 molecule relationship: CL:4030046 PR:000001012 ! lacks_plasma_membrane_part integrin alpha-M relationship: CL:4030046 PR:000001084 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD8 alpha chain relationship: RO:0002104 PR:000001026 ! has plasma membrane part lymphocyte antigen 75 relationship: RO:0002202 CL:0002010 ! develops from pre-conventional dendritic cell relationship: RO:0002215 GO:0002474 ! capable of antigen processing and presentation of peptide antigen via MHC class I [Term] id: CL:0000999 name: CD4-positive CD11b-positive dendritic cell def: "CD8-alpha-negative CD11b-positive dendritic cell is a conventional dendritic cell that is CD11b-positive, CD4-positive and is CD205-negative and CD8-alpha-negative." [GO_REF:0000031, GOC:amm, GOC:tfm, PMCID:PMC2346585] comment: Defined as having a disposition to secreting anti-inflammatory cytokines. These markers are associated with mouse cells. Originally described in the dendritic cell ontology (DC_CL:0000012)(PMID:19243617). subset: human_subset subset: mouse_subset synonym: "DC.4+" EXACT [] is_a: CL:0000766 ! myeloid leukocyte is_a: CL:0002465 ! CD11b-positive dendritic cell intersection_of: CL:0002465 ! CD11b-positive dendritic cell intersection_of: CL:4030046 PR:000001026 ! lacks_plasma_membrane_part lymphocyte antigen 75 intersection_of: CL:4030046 PR:000001084 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD8 alpha chain intersection_of: RO:0002104 PR:000001004 ! has plasma membrane part CD4 molecule intersection_of: RO:0002215 GO:0001816 ! capable of cytokine production intersection_of: RO:0002215 GO:0050728 ! capable of negative regulation of inflammatory response relationship: CL:4030046 PR:000001026 ! lacks_plasma_membrane_part lymphocyte antigen 75 relationship: CL:4030046 PR:000001084 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD8 alpha chain relationship: RO:0002104 PR:000001004 ! has plasma membrane part CD4 molecule relationship: RO:0002202 CL:0002010 ! develops from pre-conventional dendritic cell relationship: RO:0002215 GO:0050728 ! capable of negative regulation of inflammatory response [Term] id: CL:0001000 name: CD8-alpha-positive CD11b-negative dendritic cell def: "CD8-alpha-positive CD11b-negative dendritic cell is a conventional dendritic cell that is CD11b-negative, CD4-negative and is CD205-positive and CD8-alpha-positive." [GO_REF:0000031, GOC:amm, GOC:tfm, PMCID:PMC2346585] comment: Cells are defined as having a disposition to secreting inflammatory cytokines. Originally described in the dendritic cell ontology (DC_CL:0000013)(PMID:19243617). subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "DC.8+" EXACT [] is_a: CL:0000766 ! myeloid leukocyte is_a: CL:0000990 {is_inferred="true"} ! conventional dendritic cell intersection_of: CL:0000990 ! conventional dendritic cell intersection_of: CL:4030046 PR:000001004 ! lacks_plasma_membrane_part CD4 molecule intersection_of: CL:4030046 PR:000001012 ! lacks_plasma_membrane_part integrin alpha-M intersection_of: RO:0002104 PR:000001026 ! has plasma membrane part lymphocyte antigen 75 intersection_of: RO:0002104 PR:000001084 ! has plasma membrane part T-cell surface glycoprotein CD8 alpha chain intersection_of: RO:0002215 GO:0001816 ! capable of cytokine production intersection_of: RO:0002215 GO:0042590 ! capable of antigen processing and presentation of exogenous peptide antigen via MHC class I intersection_of: RO:0002215 GO:0050729 ! capable of positive regulation of inflammatory response relationship: CL:4030046 PR:000001004 ! lacks_plasma_membrane_part CD4 molecule relationship: CL:4030046 PR:000001012 ! lacks_plasma_membrane_part integrin alpha-M relationship: RO:0002104 PR:000001026 ! has plasma membrane part lymphocyte antigen 75 relationship: RO:0002104 PR:000001084 ! has plasma membrane part T-cell surface glycoprotein CD8 alpha chain relationship: RO:0002202 CL:0002010 ! develops from pre-conventional dendritic cell relationship: RO:0002215 GO:0042590 ! capable of antigen processing and presentation of exogenous peptide antigen via MHC class I relationship: RO:0002215 GO:0050729 ! capable of positive regulation of inflammatory response [Term] id: CL:0001001 name: immature CD8-alpha-negative CD11b-negative dendritic cell def: "Immature CD8-alpha-negative CD11b-negative dendritic cell is a CD8-alpha-negative CD11b-negative dendritic cell that is CD80-low, CD86-low, and MHCII-low." [GO_REF:0000031, GOC:amm, PMCID:PMC2346585] comment: These markers are associated with mouse cells. Originally described in the dendritic cell ontology (DC_CL:0000014)(PMID:19243617). subset: human_subset subset: mouse_subset is_a: CL:0000840 ! immature conventional dendritic cell is_a: CL:0000998 {is_inferred="true"} ! CD8-alpha-negative CD11b-negative dendritic cell intersection_of: CL:0000998 ! CD8-alpha-negative CD11b-negative dendritic cell intersection_of: RO:0015016 GO:0042613 ! has low plasma membrane amount MHC class II protein complex intersection_of: RO:0015016 PR:000001412 ! has low plasma membrane amount CD86 molecule intersection_of: RO:0015016 PR:000001438 ! has low plasma membrane amount CD80 molecule [Term] id: CL:0001002 name: mature CD8-alpha-negative CD11b-negative dendritic cell def: "Mature CD8-alpha-negative CD11b-negative dendritic cell is a CD8-alpha-negative CD11b-negative dendritic cell that is CD80-high, CD86-high, MHCII-high and is CD83-positive." [GO_REF:0000031, GOC:amm, GOC:tfm, PMCID:PMC2346585] comment: These markers are associated with mouse cells. Defined as having a disposition to secretion of anti-inflammatory cytokines. Originally described in the dendritic cell ontology (DC_CL:0000015)(PMID:19243617). subset: human_subset subset: mouse_subset is_a: CL:0000841 ! mature conventional dendritic cell is_a: CL:0000998 {is_inferred="true"} ! CD8-alpha-negative CD11b-negative dendritic cell intersection_of: CL:0000998 ! CD8-alpha-negative CD11b-negative dendritic cell intersection_of: RO:0002104 PR:000001310 ! has plasma membrane part CD83 molecule intersection_of: RO:0002215 GO:0001816 ! capable of cytokine production intersection_of: RO:0015015 GO:0042613 ! has high plasma membrane amount MHC class II protein complex intersection_of: RO:0015015 PR:000001412 ! has high plasma membrane amount CD86 molecule intersection_of: RO:0015015 PR:000001438 ! has high plasma membrane amount CD80 molecule relationship: RO:0002202 CL:0001001 ! develops from immature CD8-alpha-negative CD11b-negative dendritic cell [Term] id: CL:0001003 name: mature CD8-alpha-negative CD11b-positive dendritic cell def: "Mature CD8-alpha-negative CD11b-positive dendritic cell is a CD8-alpha-negative CD11b-positive dendritic cell that is CD80-high, CD86-high, MHCII-high and is CD83-positive." [GO_REF:0000031, GOC:amm, GOC:tfm, PMCID:PMC2346585] comment: Originally described in the dendritic cell ontology (DC_CL:0000016)(PMID:19243617). subset: human_subset subset: mouse_subset is_a: CL:0000841 ! mature conventional dendritic cell is_a: CL:0000999 {is_inferred="true"} ! CD4-positive CD11b-positive dendritic cell intersection_of: CL:0000999 ! CD4-positive CD11b-positive dendritic cell intersection_of: RO:0002104 PR:000001310 ! has plasma membrane part CD83 molecule intersection_of: RO:0015015 GO:0042613 ! has high plasma membrane amount MHC class II protein complex intersection_of: RO:0015015 PR:000001412 ! has high plasma membrane amount CD86 molecule intersection_of: RO:0015015 PR:000001438 ! has high plasma membrane amount CD80 molecule relationship: RO:0002202 CL:0000997 ! develops from immature CD8-alpha-negative CD11b-positive dendritic cell [Term] id: CL:0001004 name: immature CD8-alpha-positive CD11b-negative dendritic cell def: "Immature CD8-alpha-positive CD11b-negative dendritic cell is a CD8-alpha-positive CD11b-negative dendritic cell that is CD80-low, CD86-low, and MHCII-low." [GO_REF:0000031, GOC:amm, GOC:tfm, PMCID:PMC2346585] comment: Originally described in the dendritic cell ontology (DC_CL:0000017)(PMID:19243617). subset: human_subset subset: mouse_subset is_a: CL:0000840 ! immature conventional dendritic cell is_a: CL:0001000 {is_inferred="true"} ! CD8-alpha-positive CD11b-negative dendritic cell intersection_of: CL:0001000 ! CD8-alpha-positive CD11b-negative dendritic cell intersection_of: RO:0015016 GO:0042613 ! has low plasma membrane amount MHC class II protein complex intersection_of: RO:0015016 PR:000001412 ! has low plasma membrane amount CD86 molecule intersection_of: RO:0015016 PR:000001438 ! has low plasma membrane amount CD80 molecule [Term] id: CL:0001005 name: mature CD8-alpha-positive CD11b-negative dendritic cell def: "Mature CD8-alpha-positive CD11b-negative dendritic cell is a CD8-alpha-positive CD11b-negative dendritic cell that is CD80-high, CD86-high, MHCII-high and is CD83-positive." [GO_REF:0000031, GOC:amm, PMCID:PMC2346585] comment: Originally described in the dendritic cell ontology (DC_CL:0000018)(PMID:19243617). subset: human_subset subset: mouse_subset is_a: CL:0000841 ! mature conventional dendritic cell is_a: CL:0001000 {is_inferred="true"} ! CD8-alpha-positive CD11b-negative dendritic cell intersection_of: CL:0001000 ! CD8-alpha-positive CD11b-negative dendritic cell intersection_of: RO:0002104 PR:000001310 ! has plasma membrane part CD83 molecule intersection_of: RO:0015015 GO:0042613 ! has high plasma membrane amount MHC class II protein complex intersection_of: RO:0015015 PR:000001412 ! has high plasma membrane amount CD86 molecule intersection_of: RO:0015015 PR:000001438 ! has high plasma membrane amount CD80 molecule relationship: RO:0002202 CL:0001004 ! develops from immature CD8-alpha-positive CD11b-negative dendritic cell [Term] id: CL:0001006 name: dermal dendritic cell def: "Dermal dendritic cell is a conventional dendritic cell that is CD11b-positive, CD205-positive and CD8 alpha-negative." [GO_REF:0000031, GOC:amm, PMCID:PMC2346585] comment: Originally described in the dendritic cell ontology (DC_CL:0000019)(PMID:19243617). These cells are also CD281-positive (TLR1), CD282-positive (TLR2), CD283-positive (TLR3), CD284-positive (TLR4), CD285-positive (TLR5), CD288-positive (TLR8), and CD289-positive (TLR9). subset: human_reference_atlas subset: human_subset subset: mouse_subset xref: BTO:0004812 is_a: CL:0002465 ! CD11b-positive dendritic cell intersection_of: CL:0000990 ! conventional dendritic cell intersection_of: BFO:0000050 UBERON:0002067 ! part of dermis intersection_of: RO:0002104 PR:000001012 ! has plasma membrane part integrin alpha-M intersection_of: RO:0002104 PR:000001026 ! has plasma membrane part lymphocyte antigen 75 intersection_of: RO:0002104 PR:000001084 ! has plasma membrane part T-cell surface glycoprotein CD8 alpha chain relationship: BFO:0000050 UBERON:0002067 ! part of dermis relationship: RO:0002104 PR:000001026 ! has plasma membrane part lymphocyte antigen 75 relationship: RO:0002104 PR:000001084 ! has plasma membrane part T-cell surface glycoprotein CD8 alpha chain property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0001007 name: interstitial dendritic cell def: "Interstitial dendritic cell is a conventional dendritic cell that is CD11b-positive, CD1a-positive, CD206-positive, CD209-positive, and CD36-positive." [GO_REF:0000031, GOC:amm, PMID:17850486] comment: Originally described in the dendritic cell ontology (DC_CL:0000020)(PMID:19243617). These cells are also CD281-positive (TLR1), CD282-positive (TLR2), CD283-positive (TLR3), CD284-positive (TLR4), CD286-positive (TLR6), CD288-positive (TLR8), and CD290-positive (TLR10). subset: human_subset subset: mouse_subset is_a: CL:0002465 ! CD11b-positive dendritic cell intersection_of: CL:0000990 ! conventional dendritic cell intersection_of: RO:0002104 PR:000001012 ! has plasma membrane part integrin alpha-M intersection_of: RO:0002104 PR:000001300 ! has plasma membrane part CD209 molecule intersection_of: RO:0002104 PR:000001905 ! has plasma membrane part platelet glycoprotein 4 intersection_of: RO:0002104 PR:000002025 ! has plasma membrane part T-cell surface glycoprotein CD1a intersection_of: RO:0002104 PR:000002972 ! has plasma membrane part macrophage mannose receptor 1 relationship: RO:0002104 PR:000001300 ! has plasma membrane part CD209 molecule relationship: RO:0002104 PR:000001905 ! has plasma membrane part platelet glycoprotein 4 relationship: RO:0002104 PR:000002025 ! has plasma membrane part T-cell surface glycoprotein CD1a relationship: RO:0002104 PR:000002972 ! has plasma membrane part macrophage mannose receptor 1 [Term] id: CL:0001008 name: Kit and Sca1-positive hematopoietic stem cell def: "A hematopoietic stem cell that has plasma membrane part Kit-positive, SCA-1-positive, CD150-positive and CD34-negative." [GO_REF:0000031, GOC:add, GOC:amm, GOC:tfm, PMID:17952047, PMID:19022770] comment: Cell markers are associated with mouse hematopoietic stem cell. Originally described in the dendritic cell ontology (DC_CL:0000043)(PMID:19243617). subset: human_subset subset: mouse_subset synonym: "LSK stem cell" EXACT [] synonym: "Sca1-positive hematopoietic stem cell" EXACT [] is_a: CL:0000037 {is_inferred="true"} ! hematopoietic stem cell intersection_of: CL:0000037 ! hematopoietic stem cell intersection_of: CL:4030046 PR:000001014 ! lacks_plasma_membrane_part receptor-type tyrosine-protein phosphatase C isoform CD45RABC intersection_of: CL:4030046 PR:000001084 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD8 alpha chain intersection_of: CL:4030046 PR:000001308 ! lacks_plasma_membrane_part CD48 molecule intersection_of: CL:4030046 PR:000001839 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD5 intersection_of: CL:4030046 PR:000001869 ! lacks_plasma_membrane_part interleukin-7 receptor subunit alpha intersection_of: CL:4030046 PR:000001896 ! lacks_plasma_membrane_part natural killer cell receptor 2B4 intersection_of: CL:4030046 PR:000002977 ! lacks_plasma_membrane_part killer cell lectin-like receptor subfamily B member 1C intersection_of: CL:4030046 PR:000002981 ! lacks_plasma_membrane_part lymphocyte antigen 76 (mouse) intersection_of: RO:0002104 PR:000001833 ! has plasma membrane part SLAM family member 1 intersection_of: RO:0002104 PR:000002065 ! has plasma membrane part mast/stem cell growth factor receptor intersection_of: RO:0002104 PR:000002979 ! has plasma membrane part lymphocyte antigen 6A-2/6E-1 disjoint_from: CL:0001024 ! CD34-positive, CD38-negative hematopoietic stem cell relationship: CL:4030046 PR:000001014 ! lacks_plasma_membrane_part receptor-type tyrosine-protein phosphatase C isoform CD45RABC relationship: CL:4030046 PR:000001308 ! lacks_plasma_membrane_part CD48 molecule relationship: CL:4030046 PR:000001869 ! lacks_plasma_membrane_part interleukin-7 receptor subunit alpha relationship: CL:4030046 PR:000001896 ! lacks_plasma_membrane_part natural killer cell receptor 2B4 relationship: CL:4030046 PR:000002977 ! lacks_plasma_membrane_part killer cell lectin-like receptor subfamily B member 1C relationship: RO:0002104 PR:000001833 ! has plasma membrane part SLAM family member 1 relationship: RO:0002104 PR:000002065 ! has plasma membrane part mast/stem cell growth factor receptor relationship: RO:0002104 PR:000002979 ! has plasma membrane part lymphocyte antigen 6A-2/6E-1 [Term] id: CL:0001009 name: immature dermal dendritic cell def: "Immature dermal dendritic cell is a dermal dendritic cell that is CD80-low, CD86-low, and MHCII-low." [GO_REF:0000031, GOC:amm, PMCID:PMC2346585] comment: Originally described in the dendritic cell ontology (DC_CL:0000022)(PMID:19243617). subset: human_subset subset: mouse_subset is_a: CL:0000840 ! immature conventional dendritic cell is_a: CL:0001006 {is_inferred="true"} ! dermal dendritic cell intersection_of: CL:0001006 ! dermal dendritic cell intersection_of: RO:0015016 GO:0042613 ! has low plasma membrane amount MHC class II protein complex intersection_of: RO:0015016 PR:000001412 ! has low plasma membrane amount CD86 molecule intersection_of: RO:0015016 PR:000001438 ! has low plasma membrane amount CD80 molecule [Term] id: CL:0001010 name: mature dermal dendritic cell def: "Mature dermal dendritic cell is a dermal dendritic cell that is CD80-high, CD86-high, MHCII-high and is CD83-positive." [GO_REF:0000031, GOC:amm, PMCID:PMC2346585] comment: Originally described in the dendritic cell ontology (DC_CL:0000023)(PMID:19243617). subset: human_subset subset: mouse_subset is_a: CL:0000841 ! mature conventional dendritic cell is_a: CL:0001006 {is_inferred="true"} ! dermal dendritic cell intersection_of: CL:0001006 ! dermal dendritic cell intersection_of: RO:0002104 PR:000001310 ! has plasma membrane part CD83 molecule intersection_of: RO:0015015 GO:0042613 ! has high plasma membrane amount MHC class II protein complex intersection_of: RO:0015015 PR:000001412 ! has high plasma membrane amount CD86 molecule intersection_of: RO:0015015 PR:000001438 ! has high plasma membrane amount CD80 molecule relationship: RO:0002202 CL:0001009 ! develops from immature dermal dendritic cell [Term] id: CL:0001011 name: immature interstitial dendritic cell def: "Immature interstitial dendritic cell is a interstitial dendritic cell that is CD80-low, CD86-low, and MHCII-low." [GO_REF:0000031, GOC:amm, GOC:tfm, PMID:17850486] comment: Originally described in the dendritic cell ontology (DC_CL:0000024)(PMID:19243617). subset: human_subset subset: mouse_subset is_a: CL:0000840 ! immature conventional dendritic cell is_a: CL:0001007 {is_inferred="true"} ! interstitial dendritic cell intersection_of: CL:0001007 ! interstitial dendritic cell intersection_of: RO:0015016 GO:0042613 ! has low plasma membrane amount MHC class II protein complex intersection_of: RO:0015016 PR:000001412 ! has low plasma membrane amount CD86 molecule intersection_of: RO:0015016 PR:000001438 ! has low plasma membrane amount CD80 molecule [Term] id: CL:0001012 name: CD7-negative lymphoid progenitor OR granulocyte monocyte progenitor comment: Originally described in the dendritic cell ontology (DC_CL:1110000)(PMID:19243617). subset: human_subset subset: mouse_subset is_a: CL:0001060 ! hematopoietic oligopotent progenitor cell, lineage-negative is_a: CL:0011026 ! progenitor cell union_of: CL:0000557 ! granulocyte monocyte progenitor cell union_of: CL:0001027 ! CD7-negative lymphoid progenitor cell [Term] id: CL:0001013 name: mature interstitial dendritic cell def: "Mature interstitial dendritic cell is a interstitial dendritic cell that is CD80-high, CD86-high, MHCII-high and is CD83-positive." [GO_REF:0000031, GOC:amm, GOC:tfm, PMID:17850486] comment: Originally described in the dendritic cell ontology (DC_CL:0000025)(PMID:19243617). subset: human_subset subset: mouse_subset is_a: CL:0000841 ! mature conventional dendritic cell is_a: CL:0001007 {is_inferred="true"} ! interstitial dendritic cell intersection_of: CL:0001007 ! interstitial dendritic cell intersection_of: RO:0002104 PR:000001310 ! has plasma membrane part CD83 molecule intersection_of: RO:0015015 GO:0042613 ! has high plasma membrane amount MHC class II protein complex intersection_of: RO:0015015 PR:000001412 ! has high plasma membrane amount CD86 molecule intersection_of: RO:0015015 PR:000001438 ! has high plasma membrane amount CD80 molecule relationship: RO:0002202 CL:0001011 ! develops from immature interstitial dendritic cell [Term] id: CL:0001014 name: CD1a-positive Langerhans cell def: "CD1a-positive Langerhans cell is a Langerhans_cell that is CD1a-positive and CD324-positive." [GO_REF:0000031, GOC:amm, PMID:17850486] comment: These markers are associated with human cells. Originally described in the dendritic cell ontology (DC_CL:0000026)(PMID:19243617). These cells are also CD281-positive (TLR1), CD282-positive (TLR2), CD284-positive (TLR4), CD286-positive (TLR6), CD287-positive (TLR7), and CD290-positive (TLR10). When activated, these cells are capable of producing IL-6, IL-8, and IL-15. subset: human_subset subset: mouse_subset synonym: "CD1a-LC" EXACT [] is_a: CL:0000453 {is_inferred="true"} ! Langerhans cell intersection_of: CL:0000453 ! Langerhans cell intersection_of: RO:0002104 PR:000001447 ! has plasma membrane part cadherin-1 intersection_of: RO:0002104 PR:000002025 ! has plasma membrane part T-cell surface glycoprotein CD1a relationship: RO:0002104 PR:000001447 ! has plasma membrane part cadherin-1 relationship: RO:0002104 PR:000002025 ! has plasma membrane part T-cell surface glycoprotein CD1a [Term] id: CL:0001015 name: CD8-alpha-low Langerhans cell def: "CD8-alpha-low Langerhans cell is a Langerhans cell that is CD205-high and is CD8-alpha-low." [GO_REF:0000031, GOC:amm, PMCID:PMC2346585] comment: These markers are associated with mouse cells. Originally described in the dendritic cell ontology (DC_CL:0000027)(PMID:19243617). They are also CD205-high, CD281-positive (TLR1), CD282-positive (TLR2), CD283-positive (TLR3), CD285-positive (TLR5), CD286-positive (TLR6), and CD289-positive (TLR9). subset: human_subset subset: mouse_subset is_a: CL:0000453 {is_inferred="true"} ! Langerhans cell intersection_of: CL:0000453 ! Langerhans cell intersection_of: RO:0015015 PR:000001026 ! has high plasma membrane amount lymphocyte antigen 75 intersection_of: RO:0015016 PR:000001084 ! has low plasma membrane amount T-cell surface glycoprotein CD8 alpha chain relationship: RO:0015015 PR:000001026 ! has high plasma membrane amount lymphocyte antigen 75 relationship: RO:0015016 PR:000001084 ! has low plasma membrane amount T-cell surface glycoprotein CD8 alpha chain [Term] id: CL:0001016 name: immature CD1a-positive Langerhans cell def: "Immature CD1a-positive Langerhans cell is a CD1a-positive Langerhans cell that is CD80-low, CD86-low, and MHCII-low." [GO_REF:0000031, GOC:amm, GOC:tfm, PMID:17850486] comment: Originally described in the dendritic cell ontology (DC_CL:0000028)(PMID:19243617). subset: human_subset subset: mouse_subset is_a: CL:0000840 ! immature conventional dendritic cell is_a: CL:0001014 {is_inferred="true"} ! CD1a-positive Langerhans cell intersection_of: CL:0001014 ! CD1a-positive Langerhans cell intersection_of: RO:0015016 GO:0042613 ! has low plasma membrane amount MHC class II protein complex intersection_of: RO:0015016 PR:000001412 ! has low plasma membrane amount CD86 molecule intersection_of: RO:0015016 PR:000001438 ! has low plasma membrane amount CD80 molecule [Term] id: CL:0001017 name: mature CD1a-positive Langerhans cell def: "Mature CD1a-positive Langerhans cell is a CD1a-positive Langerhans cell that is CD80-high, CD86-high, MHCII-high and is CD83-positive." [GO_REF:0000031, GOC:amm, GOC:tfm, PMID:17850486] comment: Originally described in the dendritic cell ontology (DC_CL:0000029)(PMID:19243617). When activated, these cells produce IL-6, IL-8, and IL-15. subset: human_subset subset: mouse_subset is_a: CL:0000841 ! mature conventional dendritic cell is_a: CL:0001014 {is_inferred="true"} ! CD1a-positive Langerhans cell intersection_of: CL:0001014 ! CD1a-positive Langerhans cell intersection_of: RO:0002104 PR:000001310 ! has plasma membrane part CD83 molecule intersection_of: RO:0015015 GO:0042613 ! has high plasma membrane amount MHC class II protein complex intersection_of: RO:0015015 PR:000001412 ! has high plasma membrane amount CD86 molecule intersection_of: RO:0015015 PR:000001438 ! has high plasma membrane amount CD80 molecule relationship: RO:0002202 CL:0001016 ! develops from immature CD1a-positive Langerhans cell [Term] id: CL:0001018 name: immature CD8-alpha-low Langerhans cell def: "Immature CD8-alpha-low Langerhans cell is a CD8-alpha-low Langerhans cell that is CD80-low, CD86-low, and MHCII-low." [GO_REF:0000031, GOC:amm, GOC:tfm, PMCID:PMC2346585] comment: These markers are associated with mouse cells. Originally described in the dendritic cell ontology (DC_CL:0000030)(PMID:19243617). subset: human_subset subset: mouse_subset is_a: CL:0000840 ! immature conventional dendritic cell is_a: CL:0001015 {is_inferred="true"} ! CD8-alpha-low Langerhans cell intersection_of: CL:0001015 ! CD8-alpha-low Langerhans cell intersection_of: RO:0015016 GO:0042613 ! has low plasma membrane amount MHC class II protein complex intersection_of: RO:0015016 PR:000001412 ! has low plasma membrane amount CD86 molecule intersection_of: RO:0015016 PR:000001438 ! has low plasma membrane amount CD80 molecule [Term] id: CL:0001019 name: CD115-positive monocyte OR common dendritic progenitor comment: Originally described in the dendritic cell ontology (DC_CL:1111000)(PMID:19243617). subset: human_subset subset: mouse_subset is_a: CL:0000763 ! myeloid cell is_a: CL:0002031 ! hematopoietic lineage restricted progenitor cell union_of: CL:0001022 ! CD115-positive monocyte union_of: CL:0001029 ! common dendritic progenitor [Term] id: CL:0001020 name: mature CD8-alpha-low Langerhans cell def: "Mature CD8-alpha-low Langerhans cell is a CD8-alpha-low Langerhans cell that that is CD80-high, CD86-high, MHCII-high and is CD83-positive." [GO_REF:0000031, GOC:amm, PMCID:PMC2346585] comment: These markers are associated with mouse cells. Originally described in the dendritic cell ontology (DC_CL:0000031)(PMID:19243617). subset: human_subset subset: mouse_subset is_a: CL:0000841 ! mature conventional dendritic cell is_a: CL:0001015 {is_inferred="true"} ! CD8-alpha-low Langerhans cell intersection_of: CL:0001015 ! CD8-alpha-low Langerhans cell intersection_of: RO:0002104 PR:000001310 ! has plasma membrane part CD83 molecule intersection_of: RO:0015015 GO:0042613 ! has high plasma membrane amount MHC class II protein complex intersection_of: RO:0015015 PR:000001412 ! has high plasma membrane amount CD86 molecule intersection_of: RO:0015015 PR:000001438 ! has high plasma membrane amount CD80 molecule relationship: RO:0002202 CL:0001018 ! develops from immature CD8-alpha-low Langerhans cell [Term] id: CL:0001021 name: CD34-positive, CD38-positive common lymphoid progenitor def: "A common lymphoid progenitor that is CD10-positive, CD45RA-positive, CD34-positive and CD38-positive." [GO_REF:0000031, GOC:add, GOC:amm, GOC:tfm, PMCID:PMC2346585, PMID:19022770] comment: These markers are associated with human common lymphoid progenitors. Originally described in the dendritic cell ontology (DC_CL:0000032)(PMID:19243617). subset: human_subset subset: mouse_subset synonym: "CD10-positive common lymphocyte precursor" EXACT [] synonym: "CD10-positive common lymphocyte progenitor" EXACT [] synonym: "CD10-positive common lymphoid precursor" EXACT [] is_a: CL:0000051 {is_inferred="true"} ! common lymphoid progenitor is_a: CL:0000995 ! CD34-positive, CD38-positive common myeloid progenitor OR CD34-positive, CD38-positive common lymphoid progenitor intersection_of: CL:0000051 ! common lymphoid progenitor intersection_of: RO:0002104 PR:000001003 ! has plasma membrane part CD34 molecule intersection_of: RO:0002104 PR:000001015 ! has plasma membrane part receptor-type tyrosine-protein phosphatase C isoform CD45RA intersection_of: RO:0002104 PR:000001408 ! has plasma membrane part ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 intersection_of: RO:0002104 PR:000001898 ! has plasma membrane part neprilysin disjoint_from: CL:0001025 ! Kit-positive, Sca1-positive common lymphoid progenitor relationship: RO:0002104 PR:000001003 ! has plasma membrane part CD34 molecule relationship: RO:0002104 PR:000001015 ! has plasma membrane part receptor-type tyrosine-protein phosphatase C isoform CD45RA relationship: RO:0002104 PR:000001408 ! has plasma membrane part ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 relationship: RO:0002104 PR:000001898 ! has plasma membrane part neprilysin relationship: RO:0002202 CL:0002043 ! develops from CD34-positive, CD38-negative multipotent progenitor cell [Term] id: CL:0001022 name: CD115-positive monocyte def: "CD115-positive monocyte is a monocyte that is CD115-positive and CD11b-positive." [GO_REF:0000031, GOC:add, GOC:amm, PMID:17952047] comment: These markers are associated with human cells. Originally described in the dendritic cell ontology (DC_CL:0000033)(PMID:19243617). subset: human_subset subset: mouse_subset is_a: CL:0000576 {is_inferred="true"} ! monocyte is_a: CL:0000839 ! myeloid lineage restricted progenitor cell is_a: CL:0001019 ! CD115-positive monocyte OR common dendritic progenitor intersection_of: CL:0000576 ! monocyte intersection_of: RO:0002104 PR:000001012 ! has plasma membrane part integrin alpha-M intersection_of: RO:0002104 PR:000002062 ! has plasma membrane part macrophage colony-stimulating factor 1 receptor relationship: RO:0002104 PR:000001012 ! has plasma membrane part integrin alpha-M relationship: RO:0002104 PR:000002062 ! has plasma membrane part macrophage colony-stimulating factor 1 receptor relationship: RO:0002202 CL:0002001 ! develops from CD34-positive, CD38-positive granulocyte monocyte progenitor [Term] id: CL:0001023 name: Kit-positive, CD34-positive common myeloid progenitor def: "A common myeloid progenitor that is Kit-positive and CD34-positive, Il7ra-negative, and is SCA1-low and Fcgr2-low and Fcgr3-low." [GO_REF:0000031, GOC:add, GOC:amm, GOC:tfm, http://www.immgen.org/index_content.html, PMID:1261582, PMID:17952047] comment: Markers are associated with mouse cells. Originally described in the dendritic cell ontology (DC_CL:0000034)(PMID:19243617). subset: human_subset subset: mouse_subset synonym: "CD117-positive common myeloid precursor" BROAD [] is_a: CL:0001030 ! CD117-positive common myeloid progenitor OR CD217-positive common lymphoid progenitor is_a: CL:0001059 {is_inferred="true"} ! common myeloid progenitor, CD34-positive intersection_of: CL:0001059 ! common myeloid progenitor, CD34-positive intersection_of: CL:4030046 PR:000001869 ! lacks_plasma_membrane_part interleukin-7 receptor subunit alpha intersection_of: CL:4030046 PR:000002979 ! lacks_plasma_membrane_part lymphocyte antigen 6A-2/6E-1 intersection_of: RO:0002104 PR:000002065 ! has plasma membrane part mast/stem cell growth factor receptor intersection_of: RO:0015016 GO:0033001 ! has low plasma membrane amount Fc-gamma receptor III complex intersection_of: RO:0015016 PR:000001481 ! has low plasma membrane amount low affinity immunoglobulin gamma Fc region receptor II-b disjoint_from: CL:0001026 ! CD34-positive, CD38-positive common myeloid progenitor relationship: CL:4030046 PR:000001869 ! lacks_plasma_membrane_part interleukin-7 receptor subunit alpha relationship: CL:4030046 PR:000002979 ! lacks_plasma_membrane_part lymphocyte antigen 6A-2/6E-1 relationship: RO:0002104 PR:000002065 ! has plasma membrane part mast/stem cell growth factor receptor relationship: RO:0002202 CL:0002035 ! develops from Slamf1-negative multipotent progenitor cell relationship: RO:0015016 GO:0033001 ! has low plasma membrane amount Fc-gamma receptor III complex relationship: RO:0015016 PR:000001481 ! has low plasma membrane amount low affinity immunoglobulin gamma Fc region receptor II-b [Term] id: CL:0001024 name: CD34-positive, CD38-negative hematopoietic stem cell def: "CD133-positive hematopoietic stem cell is a hematopoietic stem cell that is CD34-positive, CD90-positive, and CD133-positive." [GO_REF:0000031, GOC:add, GOC:amm, GOC:tfm, PMID:10430905, PMID:11750107, PMID:16551251, PMID:20024907, PMID:9389721] comment: Cell markers are associated with human hematopoietic stem cells. Originally described in the dendritic cell ontology (DC_CL:0000035)(PMID:19243617). subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "CD133-positive hematopoietic stem cell" EXACT [PMID:16140871] xref: CALOHA:TS-0448 is_a: CL:0000037 {is_inferred="true"} ! hematopoietic stem cell intersection_of: CL:0000037 ! hematopoietic stem cell intersection_of: CL:4030046 PR:000001024 ! lacks_plasma_membrane_part neural cell adhesion molecule 1 intersection_of: CL:4030046 PR:000001408 ! lacks_plasma_membrane_part ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 intersection_of: CL:4030046 PR:000001483 ! lacks_plasma_membrane_part low affinity immunoglobulin gamma Fc region receptor III intersection_of: CL:4030046 PR:000001892 ! lacks_plasma_membrane_part CD33 molecule intersection_of: CL:4030046 PR:000001945 ! lacks_plasma_membrane_part transferrin receptor protein 1 intersection_of: RO:0002104 PR:000001003 ! has plasma membrane part CD34 molecule intersection_of: RO:0002104 PR:000001786 ! has plasma membrane part prominin-1 intersection_of: RO:0002104 PR:000001809 ! has plasma membrane part CD59-like glycoprotein intersection_of: RO:0002104 PR:000001843 ! has plasma membrane part Thy-1 membrane glycoprotein relationship: CL:4030046 PR:000001408 ! lacks_plasma_membrane_part ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 relationship: CL:4030046 PR:000001483 ! lacks_plasma_membrane_part low affinity immunoglobulin gamma Fc region receptor III relationship: CL:4030046 PR:000001892 ! lacks_plasma_membrane_part CD33 molecule relationship: CL:4030046 PR:000001945 ! lacks_plasma_membrane_part transferrin receptor protein 1 relationship: RO:0002104 PR:000001003 ! has plasma membrane part CD34 molecule relationship: RO:0002104 PR:000001786 ! has plasma membrane part prominin-1 relationship: RO:0002104 PR:000001809 ! has plasma membrane part CD59-like glycoprotein relationship: RO:0002104 PR:000001843 ! has plasma membrane part Thy-1 membrane glycoprotein [Term] id: CL:0001025 name: Kit-positive, Sca1-positive common lymphoid progenitor def: "A common lymphoid progenitor that is Kit-low, FLT3-positive, IL7ralpha-positive, and SCA1-low." [GO_REF:0000031, GOC:add, GOC:amm, GOC:tfm, http://www.immgen.org/index_content.html, PMID:17952047] comment: Markers are associated with mouse cells. subset: human_subset subset: mouse_subset synonym: "CD217-positive common lymphocyte precursor" EXACT [] synonym: "CD217-positive common lymphocyte progenitor" EXACT [] synonym: "CD217-positive common lymphoid precursor" EXACT [] is_a: CL:0000051 {is_inferred="true"} ! common lymphoid progenitor is_a: CL:0001030 ! CD117-positive common myeloid progenitor OR CD217-positive common lymphoid progenitor intersection_of: CL:0000051 ! common lymphoid progenitor intersection_of: CL:4030046 PR:000001014 ! lacks_plasma_membrane_part receptor-type tyrosine-protein phosphatase C isoform CD45RABC intersection_of: RO:0002104 PR:000001869 ! has plasma membrane part interleukin-7 receptor subunit alpha intersection_of: RO:0002104 PR:000001963 ! has plasma membrane part CD27 molecule intersection_of: RO:0002104 PR:000002001 ! has plasma membrane part receptor-type tyrosine-protein kinase FLT3 intersection_of: RO:0002104 PR:000002037 ! has plasma membrane part complement component C1q receptor intersection_of: RO:0015016 PR:000002065 ! has low plasma membrane amount mast/stem cell growth factor receptor intersection_of: RO:0015016 PR:000002979 ! has low plasma membrane amount lymphocyte antigen 6A-2/6E-1 relationship: CL:4030046 PR:000001014 ! lacks_plasma_membrane_part receptor-type tyrosine-protein phosphatase C isoform CD45RABC relationship: RO:0002104 PR:000001869 ! has plasma membrane part interleukin-7 receptor subunit alpha relationship: RO:0002104 PR:000001963 ! has plasma membrane part CD27 molecule relationship: RO:0002104 PR:000002001 ! has plasma membrane part receptor-type tyrosine-protein kinase FLT3 relationship: RO:0002104 PR:000002037 ! has plasma membrane part complement component C1q receptor relationship: RO:0002202 CL:0000936 ! develops from early lymphoid progenitor relationship: RO:0015016 PR:000002065 ! has low plasma membrane amount mast/stem cell growth factor receptor relationship: RO:0015016 PR:000002979 ! has low plasma membrane amount lymphocyte antigen 6A-2/6E-1 [Term] id: CL:0001026 name: CD34-positive, CD38-positive common myeloid progenitor def: "A common myeloid progenitor that is CD34-positive, CD38-positive, IL3ra-low, CD10-negative, CD7-negative, CD45RA-negative, and IL-5Ralpha-negative." [GO_REF:0000031, GOC:add, GOC:amm, PMCID:PMC2626675, PMID:16551251] comment: Markers are associated with human cell type. Originally described in the dendritic cell ontology (DC_CL:0000038)(PMID:19243617). subset: human_subset subset: mouse_subset synonym: "CD71-positive common myeloid precursor" NARROW [] is_a: CL:0000995 ! CD34-positive, CD38-positive common myeloid progenitor OR CD34-positive, CD38-positive common lymphoid progenitor is_a: CL:0001059 ! common myeloid progenitor, CD34-positive intersection_of: CL:0001059 ! common myeloid progenitor, CD34-positive intersection_of: CL:4030046 PR:000001015 ! lacks_plasma_membrane_part receptor-type tyrosine-protein phosphatase C isoform CD45RA intersection_of: CL:4030046 PR:000001836 ! lacks_plasma_membrane_part CD7 molecule intersection_of: CL:4030046 PR:000001867 ! lacks_plasma_membrane_part interleukin-5 receptor subunit alpha intersection_of: CL:4030046 PR:000001898 ! lacks_plasma_membrane_part neprilysin intersection_of: RO:0002104 PR:000001408 ! has plasma membrane part ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 intersection_of: RO:0015016 PR:000001865 ! has low plasma membrane amount interleukin-3 receptor class 2 alpha chain relationship: CL:4030046 PR:000001015 ! lacks_plasma_membrane_part receptor-type tyrosine-protein phosphatase C isoform CD45RA relationship: CL:4030046 PR:000001836 ! lacks_plasma_membrane_part CD7 molecule relationship: CL:4030046 PR:000001867 ! lacks_plasma_membrane_part interleukin-5 receptor subunit alpha relationship: CL:4030046 PR:000001898 ! lacks_plasma_membrane_part neprilysin relationship: RO:0002104 PR:000001408 ! has plasma membrane part ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 relationship: RO:0002202 CL:0002043 ! develops from CD34-positive, CD38-negative multipotent progenitor cell relationship: RO:0015016 PR:000001865 ! has low plasma membrane amount interleukin-3 receptor class 2 alpha chain [Term] id: CL:0001027 name: CD7-negative lymphoid progenitor cell def: "CD7-negative lymphoid progenitor cell is a lymphoid progenitor cell that is CD34-positive, CD7-negative and CD45RA-negative." [GO_REF:0000031, GOC:amm, PMID:16551251] comment: These markers are associated with human cells. Originally described in the dendritic cell ontology (DC_CL:0000039)(PMID:19243617). subset: human_subset subset: mouse_subset synonym: "CD7-negative lymphoid precursor" EXACT [] is_a: CL:0000051 {is_inferred="true"} ! common lymphoid progenitor is_a: CL:0001012 ! CD7-negative lymphoid progenitor OR granulocyte monocyte progenitor intersection_of: CL:0000051 ! common lymphoid progenitor intersection_of: CL:4030046 PR:000001015 ! lacks_plasma_membrane_part receptor-type tyrosine-protein phosphatase C isoform CD45RA intersection_of: CL:4030046 PR:000001836 ! lacks_plasma_membrane_part CD7 molecule intersection_of: RO:0002104 PR:000001003 ! has plasma membrane part CD34 molecule relationship: CL:4030046 PR:000001015 ! lacks_plasma_membrane_part receptor-type tyrosine-protein phosphatase C isoform CD45RA relationship: CL:4030046 PR:000001836 ! lacks_plasma_membrane_part CD7 molecule relationship: RO:0002104 PR:000001003 ! has plasma membrane part CD34 molecule relationship: RO:0002202 CL:0001021 ! develops from CD34-positive, CD38-positive common lymphoid progenitor [Term] id: CL:0001028 name: CD7-positive lymphoid progenitor cell def: "CD7-positive lymphoid progenitor cell is a lymphoid progenitor cell that is CD34-positive, CD7-positive and is CD45RA-negative." [GO_REF:0000031, GOC:amm, GOC:tfm, PMID:16551251, PMID:19491395] comment: These markers are associated with human cells. Originally described in the dendritic cell ontology (DC_CL:0000040)(PMID:19243617). subset: human_subset subset: mouse_subset synonym: "CD7-positive lymphoid precursor" EXACT [] is_a: CL:0000051 {is_inferred="true"} ! common lymphoid progenitor intersection_of: CL:0000051 ! common lymphoid progenitor intersection_of: CL:4030046 PR:000001015 ! lacks_plasma_membrane_part receptor-type tyrosine-protein phosphatase C isoform CD45RA intersection_of: RO:0002104 PR:000001003 ! has plasma membrane part CD34 molecule intersection_of: RO:0002104 PR:000001836 ! has plasma membrane part CD7 molecule relationship: CL:4030046 PR:000001015 ! lacks_plasma_membrane_part receptor-type tyrosine-protein phosphatase C isoform CD45RA relationship: RO:0002104 PR:000001003 ! has plasma membrane part CD34 molecule relationship: RO:0002104 PR:000001836 ! has plasma membrane part CD7 molecule relationship: RO:0002202 CL:0001027 ! develops from CD7-negative lymphoid progenitor cell [Term] id: CL:0001029 name: common dendritic progenitor def: "Common dendritic precursor is a hematopoietic progenitor cell that is CD117-low, CD135-positive, CD115-positive and lacks plasma membrane parts for hematopoietic lineage markers." [GO_REF:0000031, GOC:amm, GOC:tfm, PMID:16551251, PMID:17922016, PMID:19286519] comment: Surface markers are for mouse cells. Originally described in the dendritic cell ontology (DC_CL:0000041) CDP are reportedly CD2-negative, CD3-negative, CD4-negative, CD5-negative, CD8a-negative, CD11c-positive, CD14-negative, CD19-negative, CD20-negative, CD56-negative, B220-negative, Ly6g-negative, MHCII-positive, and Ter119-negative. (PMID:19243617). subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "CDP" EXACT [PMID:21219184] synonym: "common dendritic precursor" EXACT [] synonym: "pro-DCs" EXACT [PMID:21219184] is_a: CL:0001019 ! CD115-positive monocyte OR common dendritic progenitor intersection_of: CL:0002031 ! hematopoietic lineage restricted progenitor cell intersection_of: CL:4030046 PR:000001002 ! lacks_plasma_membrane_part CD19 molecule intersection_of: CL:4030046 PR:000001004 ! lacks_plasma_membrane_part CD4 molecule intersection_of: CL:4030046 PR:000001012 ! lacks_plasma_membrane_part integrin alpha-M intersection_of: CL:4030046 PR:000001020 ! lacks_plasma_membrane_part CD3 epsilon intersection_of: CL:4030046 PR:000001024 ! lacks_plasma_membrane_part neural cell adhesion molecule 1 intersection_of: CL:4030046 PR:000001083 ! lacks_plasma_membrane_part CD2 molecule intersection_of: CL:4030046 PR:000001084 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD8 alpha chain intersection_of: CL:4030046 PR:000001289 ! lacks_plasma_membrane_part membrane-spanning 4-domains subfamily A member 1 intersection_of: CL:4030046 PR:000001839 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD5 intersection_of: CL:4030046 PR:000001889 ! lacks_plasma_membrane_part CD14 molecule intersection_of: CL:4030046 PR:000002978 ! lacks_plasma_membrane_part lymphocyte antigen 6G intersection_of: CL:4030046 PR:000002981 ! lacks_plasma_membrane_part lymphocyte antigen 76 (mouse) intersection_of: RO:0002104 PR:000002001 ! has plasma membrane part receptor-type tyrosine-protein kinase FLT3 intersection_of: RO:0002104 PR:000002062 ! has plasma membrane part macrophage colony-stimulating factor 1 receptor intersection_of: RO:0015016 PR:000002065 ! has low plasma membrane amount mast/stem cell growth factor receptor relationship: CL:4030046 PR:000001002 ! lacks_plasma_membrane_part CD19 molecule relationship: CL:4030046 PR:000001004 ! lacks_plasma_membrane_part CD4 molecule relationship: CL:4030046 PR:000001012 ! lacks_plasma_membrane_part integrin alpha-M relationship: CL:4030046 PR:000001020 ! lacks_plasma_membrane_part CD3 epsilon relationship: CL:4030046 PR:000001024 ! lacks_plasma_membrane_part neural cell adhesion molecule 1 relationship: CL:4030046 PR:000001083 ! lacks_plasma_membrane_part CD2 molecule relationship: CL:4030046 PR:000001084 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD8 alpha chain relationship: CL:4030046 PR:000001289 ! lacks_plasma_membrane_part membrane-spanning 4-domains subfamily A member 1 relationship: CL:4030046 PR:000001839 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD5 relationship: CL:4030046 PR:000001889 ! lacks_plasma_membrane_part CD14 molecule relationship: CL:4030046 PR:000002978 ! lacks_plasma_membrane_part lymphocyte antigen 6G relationship: CL:4030046 PR:000002981 ! lacks_plasma_membrane_part lymphocyte antigen 76 (mouse) relationship: RO:0002104 PR:000002001 ! has plasma membrane part receptor-type tyrosine-protein kinase FLT3 relationship: RO:0002104 PR:000002062 ! has plasma membrane part macrophage colony-stimulating factor 1 receptor relationship: RO:0002202 CL:0002009 ! develops from macrophage dendritic cell progenitor relationship: RO:0015016 PR:000002065 ! has low plasma membrane amount mast/stem cell growth factor receptor [Term] id: CL:0001030 name: CD117-positive common myeloid progenitor OR CD217-positive common lymphoid progenitor comment: Originally described in the dendritic cell ontology (DC_CL:1111100)(PMID:19243617). subset: human_subset subset: mouse_subset is_a: CL:0001060 ! hematopoietic oligopotent progenitor cell, lineage-negative is_a: CL:0011026 ! progenitor cell union_of: CL:0001023 ! Kit-positive, CD34-positive common myeloid progenitor union_of: CL:0001025 ! Kit-positive, Sca1-positive common lymphoid progenitor [Term] id: CL:0001031 name: cerebellar granule cell def: "An excitatory granule cell with a soma located in the granular layer of cerebellar cortex. A mature cerebellar granule cell has short dendrites with a characteristic claw-like appearance and a long axon that ascends to the molecular layer where it bifurcates (except in non-teleost fish, where it does not bifurcate) and extends mediolaterally to form parallel fibers." [doi:10.12688/f1000research.15021.1, doi:10.3389/fncir.2020.611841, GOC:mah] comment: It has been noted in at least some mammalian species that granule cells are the most numerous cell type in the cerebellum and in the brain, with at least 99% of all cerebellar neurons being granule cells. {xref="doi:10.3389/fncir.2020.611841"} subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "granule cell of the cerebellum" EXACT [doi:10.3389/fncir.2020.611841] xref: BTO:0004278 xref: ZFA:0001691 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000120 ! granule cell is_a: CL:2000028 ! cerebellum glutamatergic neuron is_a: UBERON:0004121 ! ectoderm-derived structure intersection_of: CL:0000120 ! granule cell intersection_of: RO:0002100 UBERON:0002037 ! has soma location cerebellum relationship: RO:0002207 CL:0002362 ! directly develops from cerebellar granule cell precursor property_value: foaf:depiction Candelabrum:cell.jpg {dc:license="https://creativecommons.org/licenses/by-nc-nd/4.0/", xref="doi:10.3389/fnins.2020.00293"} property_value: foaf:depiction http://purl.obolibrary.org/obo/cl/images/CB_circuits_PMID3650468_f2.png {dc:license="https://creativecommons.org/licenses/by-nc-nd/4.0/", xref="doi:10.1016/j.cnp.2022.11.002"} property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0001031" xsd:string {name="cerebellar granule cell on CELLxGENE CellGuide"} property_value: skos:prefLabel "cerebellar granule cell" xsd:string property_value: terms:description "The cerebellar granule cell is a predominant type of neuron located in the granular layer of the cerebellum. These cells are among the smallest neurons in the brain, yet they constitute the bulk of the neural cells in the cerebellum, making cerebellar granule cells the most populous type of neuron in mammals. The granule cells of the cerebellum play an essential role in the functioning of the cerebellar cortex by participating in a complex neuronal network that results in coordination and fine-tuning of motor activities.\nInitiating and controlling movement is the primary functional role of cerebellar granule cells. They achieve this through highly sophisticated neuronal networking. Each granule cell gives rise to an axon that ascends into the molecular layer of the cerebellar cortex, where it bifurcates into T-shape to form parallel fibers that run perpendicular to the Purkinje cell dendrites. This structure allows a single granule cell to make synaptic contact with hundreds of Purkinje cells and thereby influence their output. Cerebellar granule cells contribute to the generation of movement by transforming unstructured input from mossy fibers into organized output to the Purkinje cells.\nUnderstanding the role of cerebellar granule cells in neural plasticity is an emerging area of study. Recent research suggests that cerebellar granule cells may be involved in learning and memory processes, particularly those related to motor learning. They display unique synaptic plasticity, equipping them with the ability to adjust their response over time, which aids in the learning and storage of motor patterns.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1016/B978-0-444-63356-9.00002-9", xref="DOI:10.1038/nn.4531", xref="DOI:10.1038/nrn3312", xref="DOI:10.1152/jn.1998.80.5.2521", xref="DOI:10.3389/fncir.2020.611841"} [Term] id: CL:0001032 name: cortical granule cell def: "Granule cell that is part of the cerebral cortex." [GOC:mah] subset: human_subset subset: mouse_subset is_a: CL:0000120 ! granule cell is_a: CL:0010012 ! cerebral cortex neuron intersection_of: CL:0000120 ! granule cell intersection_of: RO:0002100 UBERON:0000956 ! has soma location cerebral cortex property_value: skos:prefLabel "cortical granule cell" xsd:string [Term] id: CL:0001033 name: hippocampal granule cell def: "Granule cell with a soma found in the hippocampus." [GOC:mah] subset: cellxgene_subset subset: human_subset subset: mouse_subset is_a: CL:0001032 ! cortical granule cell is_a: CL:0002608 ! hippocampal neuron intersection_of: CL:0000120 ! granule cell intersection_of: RO:0002100 UBERON:0002421 ! has soma location hippocampal formation property_value: skos:prefLabel "hippocampal granule cell" xsd:string [Term] id: CL:0001034 name: cell in vitro def: "A cell that is maintained or propagated in a controlled artificial environment for use in an investigation." [ReO:mhb] comment: 'In vitro', translating literally to 'in glass', typically refers to a controlled, often sterile, laboratory setting where cells or other specimens are placed by some agent for the purpose of studying or manipulating them as part of some research investigation. 'In vitro' is intended to contrast with 'native',which refers to cells or other biological entities that are found in a natural setting. It describes unicellular organisms removed from a natural environement and multicellular organism cells removed from an organism, or cells derived in culture from such displaced cells. subset: cellxgene_subset subset: human_subset subset: mouse_subset is_a: CL:0000000 ! cell property_value: terms:contributor https://orcid.org/0000-0001-9114-8737 creation_date: 2012-01-12T09:58:38Z [Term] id: CL:0001035 name: bone cell def: "A connective tissue cell found in bone." [GO_REF:0000034, GOC:add] subset: general_cell_types_upper_slim subset: human_reference_atlas subset: human_subset subset: mouse_subset is_a: CL:0000255 ! eukaryotic cell intersection_of: CL:0000000 ! cell intersection_of: BFO:0000050 UBERON:0001474 ! part of bone element relationship: BFO:0000050 UBERON:0001474 ! part of bone element property_value: RO:0002175 NCBITaxon:9606 property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0001035" xsd:string {name="bone cell on CELLxGENE CellGuide"} property_value: terms:contributor https://orcid.org/0000-0001-9990-8331 property_value: terms:description "Bone cells, also known as osteocytes, form the building blocks of the skeletal system. They represent the most common type of bone cell, making up approximately 95% of the total bone cell population in mature adult bone tissue. Osteocytes are a stellate shape with numerous long, slender dendritic processes.\nThe formation of bone is a complex process involving the action of osteoclasts - cells that break down and reabsorb old bone, followed by osteoblasts that rebuild the bone. Osteocytes serve as coordinators for these two types of bone cells to ensure a balance in the bone remodeling process, contributing to maintaining both bone strength and mineral homeostasis.\nThe primary functions of osteocytes involve the creation, maintenance, and repair of bone tissue. They ensure that bone remodeling is performed by forming a network within the bone and communicating with other cells to help them respond to mechanical strain and damage.\nA remarkable aspect of osteocytes is their ability to perceive mechanical forces, translating them into biochemical signals that regulate bone remodeling and adaptation. Defects in osteocyte function, aside from other bone cells, have been associated with several bone disorders such as osteoporosis, renal osteodystrophy, and skeletal manifestations of diabetes.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1007/s00795-015-0099-y", xref="DOI:10.1007/s11914-012-0105-4", xref="DOI:10.1016/j.jot.2021.04.005", xref="DOI:10.1038/s41413-020-0099-y"} creation_date: 2011-11-16T04:28:16Z [Term] id: CL:0001039 name: terminally differentiated osteoblast def: "Osteoblast that is terminally differentiated, located adjacent to acellular or cellular bone tissue within periosteum, and is capable of mineralizing the matrix." [VSAO:curator] subset: human_subset subset: mouse_subset xref: VSAO:0000116 is_a: CL:0000062 ! osteoblast [Term] id: CL:0001040 name: non-terminally differentiated osteoblast def: "Osteoblast that is non-terminally differentiated and located in cellular bone tissue or under the periosteum in acellular bone." [VSAO:curator] comment: VSAO relationship simplified OBO_REL:integral_part_of VSAO:0000118 subset: human_subset subset: mouse_subset xref: VSAO:0000117 is_a: CL:0000062 ! osteoblast is_a: CL:0001035 ! bone cell is_a: CL:0011026 ! progenitor cell relationship: BFO:0000050 UBERON:0002481 ! part of bone tissue [Term] id: CL:0001041 name: CD8-positive, CXCR3-positive, alpha-beta regulatory T cell def: "A CD8-positive alpha-beta-positive T cell with the phenotype CXCR3-positive and having suppressor function. They are capable of producing IL-10, suppressing proliferation, and suppressing IFN-gamma production." [GOC:dsd, PMID:19609979] comment: These cells may be the human equivalent of murine CD8-positive, CD122-positive alpha-beta regulatory T cell. They are also found in the CD45RA-negative and CD62L-positive fraction. subset: human_subset subset: mouse_subset synonym: "CD8+CXCR3+ T cell" EXACT [] synonym: "CD8+CXCR3+ T lymphocyte" EXACT [] synonym: "CD8+CXCR3+ T(reg)" EXACT [] synonym: "CD8+CXCR3+ T-cell" EXACT [] synonym: "CD8+CXCR3+ Treg" EXACT [] synonym: "CD8-positive, CXCR3-positive, alpha-beta regulatory T lymphocyte" EXACT [] synonym: "CD8-positive, CXCR3-positive, alpha-beta regulatory T-cell" EXACT [] synonym: "CD8-positive, CXCR3-positive, alpha-beta regulatory T-lymphocyte" EXACT [] synonym: "CD8-positive, CXCR3-positive, T(reg)" EXACT [] synonym: "CD8-positive, CXCR3-positive, Treg" EXACT [] is_a: CL:0000795 {is_inferred="true"} ! CD8-positive, alpha-beta regulatory T cell intersection_of: CL:0000795 ! CD8-positive, alpha-beta regulatory T cell intersection_of: RO:0002104 PR:000001207 ! has plasma membrane part C-X-C chemokine receptor type 3 intersection_of: RO:0002215 GO:0032613 ! capable of interleukin-10 production intersection_of: RO:0002215 GO:0032689 ! capable of negative regulation of type II interferon production intersection_of: RO:0002215 GO:0042130 ! capable of negative regulation of T cell proliferation relationship: RO:0002104 PR:000001207 ! has plasma membrane part C-X-C chemokine receptor type 3 relationship: RO:0002215 GO:0032613 ! capable of interleukin-10 production relationship: RO:0002215 GO:0032689 ! capable of negative regulation of type II interferon production relationship: RO:0002215 GO:0042130 ! capable of negative regulation of T cell proliferation [Term] id: CL:0001042 name: T-helper 22 cell def: "CD4-positive, alpha-beta T cell that produces IL-22." [GOC:dsd, PMID:19578368, PMID:19578369] comment: TH22 cells are also reportedly CCR4-positive, CCR6-positive, CCR10-positive, CXCR3-negative. TH22 cells are reportedly capable of secreting IL-13. subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "helper T cell type 22" EXACT [] synonym: "T(H)-22 cell" EXACT [] synonym: "Th22 cell" EXACT [] synonym: "Th22 T cell" EXACT [] synonym: "Th22 T lymphocyte" EXACT [] synonym: "Th22 T-cell" EXACT [] synonym: "Th22 T-lymphocyte" EXACT [] is_a: CL:0000492 {is_inferred="true"} ! CD4-positive helper T cell intersection_of: CL:0000492 ! CD4-positive helper T cell intersection_of: RO:0002215 GO:0032626 ! capable of interleukin-22 production relationship: RO:0002215 GO:0032626 ! capable of interleukin-22 production [Term] id: CL:0001043 name: activated CD4-positive, alpha-beta T cell, human def: "A recently activated CD4-positive, alpha-beta T cell with the phenotype HLA-DRA-positive, CD38-positive, CD69-positive, CD62L-negative, CD127-negative, and CD25-positive." [GOC:add, PMID:22343568] comment: This cell type is compatible with the HIPC Lyoplate markers for 'activated CD4+ T cell', but includes via logical inference from its parent additional markers known to be expressed on activated CD4+ T cells. The inclusion of HLA-DRA in the definition restricts this definition to human activated CD4+ T cells, as activated mouse T cells do not express MHC class II. subset: cellxgene_subset subset: human_subset synonym: "activated CD4+ T cell" BROAD [PMID:22343568] synonym: "activated CD4-positive, alpha-beta T lymphocyte, human" EXACT [] synonym: "activated CD4-positive, alpha-beta T-cell, human" EXACT [] synonym: "activated CD4-positive, alpha-beta T-lymphocyte, human" EXACT [] is_a: CL:0000896 ! activated CD4-positive, alpha-beta T cell intersection_of: CL:0000896 ! activated CD4-positive, alpha-beta T cell intersection_of: RO:0002104 PR:000001408 ! has plasma membrane part ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 intersection_of: RO:0002104 PR:000002015 ! has plasma membrane part MHC class II histocompatibility antigen alpha chain DRA intersection_of: RO:0002162 NCBITaxon:9606 ! in taxon Homo sapiens relationship: RO:0002104 PR:000001408 ! has plasma membrane part ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 relationship: RO:0002104 PR:000002015 ! has plasma membrane part MHC class II histocompatibility antigen alpha chain DRA relationship: RO:0002162 NCBITaxon:9606 ! in taxon Homo sapiens [Term] id: CL:0001044 name: effector CD4-positive, alpha-beta T cell def: "A CD4-positive, alpha-beta T cell with the phenotype CCR7-negative, CD45RA-positive." [GOC:add, PMID:22343568] comment: This cell type is compatible with the HIPC Lyoplate markers for 'effector CD4+ T cell'. The functional characteristics of this cell type currently undefined in CL, which affects its proper placement within the hierarchy. subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "effector CD4+ T cell" BROAD [PMID:22343568] synonym: "effector CD4-positive, alpha-beta T lymphocyte" EXACT [] synonym: "effector CD4-positive, alpha-beta T-cell" EXACT [] synonym: "effector CD4-positive, alpha-beta T-lymphocyte" EXACT [] is_a: CL:0000624 ! CD4-positive, alpha-beta T cell is_a: CL:0000911 ! effector T cell intersection_of: CL:0000911 ! effector T cell intersection_of: CL:4030046 PR:000001203 ! lacks_plasma_membrane_part C-C chemokine receptor type 7 intersection_of: CL:4030046 PR:000025402 ! lacks_plasma_membrane_part T cell receptor co-receptor CD8 intersection_of: RO:0002104 GO:0042105 ! has plasma membrane part alpha-beta T cell receptor complex intersection_of: RO:0002104 PR:000001004 ! has plasma membrane part CD4 molecule intersection_of: RO:0002104 PR:000001015 ! has plasma membrane part receptor-type tyrosine-protein phosphatase C isoform CD45RA relationship: CL:4030046 PR:000001203 ! lacks_plasma_membrane_part C-C chemokine receptor type 7 relationship: RO:0002104 PR:000001015 ! has plasma membrane part receptor-type tyrosine-protein phosphatase C isoform CD45RA [Term] id: CL:0001045 name: naive CCR4-positive regulatory T cell def: "A naive regulatory T cell with the phenotype CD4-positive, CD25-positive, CD127lo, CCR4-positive, and CD45RO-negative." [GOC:add, PMID:22343568] comment: This cell type is compatible with the HIPC Lyoplate markers for 'naive CCR4+ Treg'. The definition is valid for human; its applicability for mouse and other species is unknown. subset: human_subset subset: mouse_subset synonym: "naive CCR4+ Treg" EXACT [PMID:22343568] synonym: "naive CCR4-positive regulatory T lymphocyte" EXACT [] synonym: "naive CCR4-positive regulatory T-cell" EXACT [] synonym: "naive CCR4-positive regulatory T-lymphocyte" EXACT [] is_a: CL:0001047 ! CD4-positive, CD25-positive, CCR4-positive, alpha-beta regulatory T cell is_a: CL:0002677 ! naive regulatory T cell intersection_of: CL:0002677 ! naive regulatory T cell intersection_of: CL:4030046 PR:000001017 ! lacks_plasma_membrane_part receptor-type tyrosine-protein phosphatase C isoform CD45RO intersection_of: RO:0002104 PR:000001200 ! has plasma membrane part C-C chemokine receptor type 4 relationship: CL:4030046 PR:000001017 ! lacks_plasma_membrane_part receptor-type tyrosine-protein phosphatase C isoform CD45RO [Term] id: CL:0001046 name: memory CCR4-positive regulatory T cell def: "A memory regulatory T cell with phenotype CD4-positive, CD25-positive, CD127lo, CCR4-positive, and CD45RO-positive." [GOC:add, PMID:22343568] comment: This cell type is compatible with the HIPC Lyoplate markers for 'memory CCR4+ Treg'. The definition is valid for human; its applicability for mouse and other species is unknown. subset: cellxgene_subset subset: human_subset synonym: "memory CCR4+ Treg" EXACT [PMID:22343568] synonym: "memory CCR4-positive regulatory T lymphocyte" EXACT [] synonym: "memory CCR4-positive regulatory T-cell" EXACT [] synonym: "memory CCR4-positive regulatory T-lymphocyte" EXACT [] is_a: CL:0001047 ! CD4-positive, CD25-positive, CCR4-positive, alpha-beta regulatory T cell is_a: CL:0002678 ! memory regulatory T cell intersection_of: CL:0002678 ! memory regulatory T cell intersection_of: RO:0002104 PR:000001017 ! has plasma membrane part receptor-type tyrosine-protein phosphatase C isoform CD45RO intersection_of: RO:0002104 PR:000001200 ! has plasma membrane part C-C chemokine receptor type 4 intersection_of: RO:0002162 NCBITaxon:9606 ! in taxon Homo sapiens relationship: RO:0002104 PR:000001017 ! has plasma membrane part receptor-type tyrosine-protein phosphatase C isoform CD45RO relationship: RO:0002162 NCBITaxon:9606 ! in taxon Homo sapiens [Term] id: CL:0001047 name: CD4-positive, CD25-positive, CCR4-positive, alpha-beta regulatory T cell def: "A CD4-positive, CD25-positive, alpha-beta regulatory T cell with the additional phenotype CCR4-positive." [GOC:add, PMID:22343568] comment: This cell type is compatible with the HIPC Lyoplate markers for 'CCR4+ Treg'. The definition is valid for human; its applicability for mouse and other species is unknown. subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "CCR+ Treg" EXACT [PMID:22343568] synonym: "CD4-positive, CD25-positive, CCR4-positive, alpha-beta regulatory T lymphocyte" EXACT [] synonym: "CD4-positive, CD25-positive, CCR4-positive, alpha-beta regulatory T-cell" EXACT [] synonym: "CD4-positive, CD25-positive, CCR4-positive, alpha-beta regulatory T-lymphocyte" EXACT [] is_a: CL:0000792 ! CD4-positive, CD25-positive, alpha-beta regulatory T cell intersection_of: CL:0000792 ! CD4-positive, CD25-positive, alpha-beta regulatory T cell intersection_of: RO:0002104 PR:000001200 ! has plasma membrane part C-C chemokine receptor type 4 relationship: RO:0002104 PR:000001200 ! has plasma membrane part C-C chemokine receptor type 4 [Term] id: CL:0001048 name: activated CD4-positive, CD25-positive, CCR4-positive, alpha-beta regulatory T cell, human def: "A CD4-positive, CD25-positive, CCR4-positive, alpha-beta T regulatory cell with the phenotype HLA-DRA-positive, indicating recent activation." [GOC:add, PMID:22343568] comment: This cell type is compatible with the HIPC Lyoplate markers for 'activated CCR4+ Treg'. The inclusion of HLA-DRA in the definition restricts this definition to human activated CD4+ T cells, as activated mouse T cells do not express MHC class II. subset: human_subset synonym: "activated CCR4+ Treg" EXACT [PMID:22343568] synonym: "activated CD4-positive, CD25-positive, CCR4-positive, alpha-beta regulatory T lymphocyte" EXACT [] synonym: "activated CD4-positive, CD25-positive, CCR4-positive, alpha-beta regulatory T-cell" EXACT [] synonym: "activated CD4-positive, CD25-positive, CCR4-positive, alpha-beta regulatory T-lymphocyte" EXACT [] is_a: CL:0001047 ! CD4-positive, CD25-positive, CCR4-positive, alpha-beta regulatory T cell intersection_of: CL:0001047 ! CD4-positive, CD25-positive, CCR4-positive, alpha-beta regulatory T cell intersection_of: RO:0002104 PR:000002015 ! has plasma membrane part MHC class II histocompatibility antigen alpha chain DRA intersection_of: RO:0002162 NCBITaxon:9606 ! in taxon Homo sapiens relationship: RO:0002104 PR:000002015 ! has plasma membrane part MHC class II histocompatibility antigen alpha chain DRA relationship: RO:0002162 NCBITaxon:9606 ! in taxon Homo sapiens [Term] id: CL:0001049 name: activated CD8-positive, alpha-beta T cell, human def: "A recently activated CD8-positive, alpha-beta T cell with the phenotype HLA-DRA-positive, CD38-positive, CD69-positive, CD62L-negative, CD127-negative, CCR7-negative, and CD25-positive." [GOC:add, PMID:22343568] comment: This cell type is compatible with the HIPC Lyoplate markers for 'activated CD8+ T cell', but includes via logical inference from its parent additional markers known to be expressed on activated CD8+ T cells. The inclusion of HLA-DRA in the definition restricts this definition to human activated CD8+ T cells, as activated mouse T cells do not express MHC class II. subset: cellxgene_subset subset: human_subset synonym: "activated CD8+ T cell" BROAD [PMID:22343568] synonym: "activated CD8-positive, alpha-beta T lymphocyte, human" EXACT [] synonym: "activated CD8-positive, alpha-beta T-cell, human" EXACT [] synonym: "activated CD8-positive, alpha-beta T-lymphocyte, human" EXACT [] is_a: CL:0000906 ! activated CD8-positive, alpha-beta T cell intersection_of: CL:0000906 ! activated CD8-positive, alpha-beta T cell intersection_of: RO:0002104 PR:000001408 ! has plasma membrane part ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 intersection_of: RO:0002104 PR:000002015 ! has plasma membrane part MHC class II histocompatibility antigen alpha chain DRA intersection_of: RO:0002162 NCBITaxon:9606 ! in taxon Homo sapiens relationship: RO:0002104 PR:000001408 ! has plasma membrane part ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 relationship: RO:0002104 PR:000002015 ! has plasma membrane part MHC class II histocompatibility antigen alpha chain DRA relationship: RO:0002162 NCBITaxon:9606 ! in taxon Homo sapiens [Term] id: CL:0001050 name: effector CD8-positive, alpha-beta T cell def: "A CD8-positive, alpha-beta T cell with the phenotype CCR7-negative, CD45RA-positive." [GOC:add, PMID:22343568] comment: This cell type is compatible with the HIPC Lyoplate markers for 'effector CD8+ T cell'. The functional characteristics of this cell type currently undefined in CL, which affects its proper placement within the hierarchy. subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "effector CD8+ T cell" BROAD [PMID:22343568] synonym: "effector CD8-positive, alpha-beta T lymphocyte" EXACT [] synonym: "effector CD8-positive, alpha-beta T-cell" EXACT [] synonym: "effector CD8-positive, alpha-beta T-lymphocyte" EXACT [] is_a: CL:0000625 ! CD8-positive, alpha-beta T cell is_a: CL:0000911 ! effector T cell intersection_of: CL:0000911 ! effector T cell intersection_of: CL:4030046 PR:000001004 ! lacks_plasma_membrane_part CD4 molecule intersection_of: CL:4030046 PR:000001203 ! lacks_plasma_membrane_part C-C chemokine receptor type 7 intersection_of: RO:0002104 GO:0042105 ! has plasma membrane part alpha-beta T cell receptor complex intersection_of: RO:0002104 PR:000001015 ! has plasma membrane part receptor-type tyrosine-protein phosphatase C isoform CD45RA intersection_of: RO:0002104 PR:000025402 ! has plasma membrane part T cell receptor co-receptor CD8 relationship: CL:4030046 PR:000001203 ! lacks_plasma_membrane_part C-C chemokine receptor type 7 relationship: RO:0002104 PR:000001015 ! has plasma membrane part receptor-type tyrosine-protein phosphatase C isoform CD45RA property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0001051 name: CD4-positive, CXCR3-negative, CCR6-negative, alpha-beta T cell def: "A CD4-positive, alpha-beta T cell that has the phenotype CXCR3-negative, CCR6-negative." [GOC:add, PMID:22343568] comment: This cell type is compatible with the HIPC Lyoplate markers for 'non-Th1/Th17 CD4+ T cell'. Cells of this phenotype may include T-helper 2 T cells and some naive CD4+ T cells. subset: human_subset subset: mouse_subset synonym: "CD4-positive, CXCR3-negative, CCR6-negative, alpha-beta T lymphocyte" EXACT [] synonym: "CD4-positive, CXCR3-negative, CCR6-negative, alpha-beta T-cell" EXACT [] synonym: "CD4-positive, CXCR3-negative, CCR6-negative, alpha-beta T-lymphocyte" EXACT [] synonym: "non-Th1/Th17 CD4+ T cell" BROAD [PMID:22343568] is_a: CL:0000624 ! CD4-positive, alpha-beta T cell intersection_of: CL:0000624 ! CD4-positive, alpha-beta T cell intersection_of: CL:4030046 PR:000001202 ! lacks_plasma_membrane_part C-C chemokine receptor type 6 intersection_of: CL:4030046 PR:000001207 ! lacks_plasma_membrane_part C-X-C chemokine receptor type 3 relationship: CL:4030046 PR:000001202 ! lacks_plasma_membrane_part C-C chemokine receptor type 6 relationship: CL:4030046 PR:000001207 ! lacks_plasma_membrane_part C-X-C chemokine receptor type 3 [Term] id: CL:0001052 name: CD8-positive, CXCR3-negative, CCR6-negative, alpha-beta T cell def: "A CD8-positive, alpha-beta T cell that has the phenotype CXCR3-negative, CCR6-negative." [GOC:add, PMID:22343568] comment: This cell type is compatible with the HIPC Lyoplate markers for 'non-Tc1/Tc17 CD8+ T cell'. Cells of this phenotype may include Tc2 T cells and some naive CD8+ T cells. subset: human_subset subset: mouse_subset synonym: "CD8-positive, CXCR3-negative, CCR6-negative, alpha-beta T lymphocyte" EXACT [] synonym: "CD8-positive, CXCR3-negative, CCR6-negative, alpha-beta T-cell" EXACT [] synonym: "CD8-positive, CXCR3-negative, CCR6-negative, alpha-beta T-lymphocyte" EXACT [] synonym: "non-Tc1/Tc17 CD8+ T cell" BROAD [PMID:22343568] is_a: CL:0000625 ! CD8-positive, alpha-beta T cell intersection_of: CL:0000625 ! CD8-positive, alpha-beta T cell intersection_of: CL:4030046 PR:000001202 ! lacks_plasma_membrane_part C-C chemokine receptor type 6 intersection_of: CL:4030046 PR:000001207 ! lacks_plasma_membrane_part C-X-C chemokine receptor type 3 relationship: CL:4030046 PR:000001202 ! lacks_plasma_membrane_part C-C chemokine receptor type 6 relationship: CL:4030046 PR:000001207 ! lacks_plasma_membrane_part C-X-C chemokine receptor type 3 [Term] id: CL:0001053 name: IgD-negative memory B cell def: "A memory B cell that lacks expression of surface IgD." [GOC:add, PMID:22343568] comment: This cell type is compatible with the HIPC Lyoplate markers for 'IgD- memory B cell'. The majority of these cells are class-switched, though some are IgM-positive. subset: human_subset subset: mouse_subset synonym: "IgD- memory B cell" EXACT [PMID:22343568] is_a: CL:0000787 ! memory B cell intersection_of: CL:0000787 ! memory B cell intersection_of: CL:4030046 GO:0071738 ! lacks_plasma_membrane_part IgD immunoglobulin complex relationship: CL:4030046 GO:0071738 ! lacks_plasma_membrane_part IgD immunoglobulin complex [Term] id: CL:0001054 name: CD14-positive monocyte def: "A monocyte that expresses CD14 and is negative for the lineage markers CD3, CD19, and CD20." [GOC:add, PMID:22343568] comment: This cell type is compatible with the HIPC Lyoplate markers for 'monocyte'. Note that while CD14 is considered a reliable marker for human monocytes, it is only expressed on approximately 85% of mouse monocytes. subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "monocyte" NARROW [PMID:22343568] is_a: CL:0000576 ! monocyte intersection_of: CL:0000576 ! monocyte intersection_of: CL:4030046 PR:000001002 ! lacks_plasma_membrane_part CD19 molecule intersection_of: CL:4030046 PR:000001020 ! lacks_plasma_membrane_part CD3 epsilon intersection_of: CL:4030046 PR:000001289 ! lacks_plasma_membrane_part membrane-spanning 4-domains subfamily A member 1 intersection_of: RO:0002104 PR:000001889 ! has plasma membrane part CD14 molecule relationship: CL:4030046 PR:000001002 ! lacks_plasma_membrane_part CD19 molecule relationship: CL:4030046 PR:000001020 ! lacks_plasma_membrane_part CD3 epsilon relationship: CL:4030046 PR:000001289 ! lacks_plasma_membrane_part membrane-spanning 4-domains subfamily A member 1 relationship: RO:0002104 PR:000001889 ! has plasma membrane part CD14 molecule property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0001055 name: CD14-positive, CD16-low monocyte def: "An intermediate monocyte that is CD14-positive and with low amounts of CD16." [GOC:add, PMID:20628149] comment: Definition is valid for human intermediate monocytes. subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "intermediate monocyte, human" EXACT [] is_a: CL:0002393 ! intermediate monocyte is_a: CL:0002397 ! CD14-positive, CD16-positive monocyte intersection_of: CL:0002393 ! intermediate monocyte intersection_of: RO:0002104 PR:000001889 ! has plasma membrane part CD14 molecule intersection_of: RO:0015016 PR:000001483 ! has low plasma membrane amount low affinity immunoglobulin gamma Fc region receptor III relationship: RO:0015016 PR:000001483 ! has low plasma membrane amount low affinity immunoglobulin gamma Fc region receptor III property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0001056 name: dendritic cell, human def: "A dendritic cell with the phenotype HLA-DRA-positive." [GOC:add, PMID:22343568] comment: This cell type is compatible with the HIPC Lyoplate markers for 'dendritic cell'. The inclusion of HLA-DRA in the definition restricts this definition to human dendritic cells. subset: cellxgene_subset subset: human_reference_atlas subset: human_subset synonym: "dendritic cell" BROAD [PMID:22343568] is_a: CL:0000451 ! dendritic cell intersection_of: CL:0000451 ! dendritic cell intersection_of: RO:0002104 PR:000002015 ! has plasma membrane part MHC class II histocompatibility antigen alpha chain DRA intersection_of: RO:0002162 NCBITaxon:9606 ! in taxon Homo sapiens relationship: RO:0002104 PR:000002015 ! has plasma membrane part MHC class II histocompatibility antigen alpha chain DRA relationship: RO:0002162 NCBITaxon:9606 ! in taxon Homo sapiens property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0001057 name: myeloid dendritic cell, human def: "A myeloid dendritic cell with the phenotype HLA-DRA-positive." [GOC:add, PMID:22343568] comment: This cell type is compatible with the HIPC Lyoplate markers for 'myeloid dendritic cell'. The inclusion of HLA-DRA in the definition restricts this definition to human myeloid dendritic cells. subset: cellxgene_subset subset: human_subset synonym: "myeloid dendritic cell" BROAD [PMID:22343568] is_a: CL:0000782 ! myeloid dendritic cell is_a: CL:0001056 ! dendritic cell, human intersection_of: CL:0000782 ! myeloid dendritic cell intersection_of: RO:0002104 PR:000002015 ! has plasma membrane part MHC class II histocompatibility antigen alpha chain DRA intersection_of: RO:0002162 NCBITaxon:9606 ! in taxon Homo sapiens [Term] id: CL:0001058 name: plasmacytoid dendritic cell, human def: "A plasmacytoid dendritic cell with the phenotype HLA-DRA-positive, CD123-positive, and CD11c-negative." [GOC:add, PMID:22343568] comment: This cell type is compatible with the HIPC Lyoplate markers for 'plasmacytoid dendritic cell'. The inclusion of HLA-DRA in the definition restricts this definition to human plasmacytoid dendritic cells. subset: cellxgene_subset subset: human_reference_atlas subset: human_subset synonym: "plasmacytoid dendritic cell" BROAD [PMID:22343568] is_a: CL:0000784 ! plasmacytoid dendritic cell is_a: CL:0001056 ! dendritic cell, human intersection_of: CL:0000784 ! plasmacytoid dendritic cell intersection_of: CL:4030046 PR:000001013 ! lacks_plasma_membrane_part integrin alpha-X intersection_of: RO:0002104 PR:000001865 ! has plasma membrane part interleukin-3 receptor class 2 alpha chain intersection_of: RO:0002104 PR:000002015 ! has plasma membrane part MHC class II histocompatibility antigen alpha chain DRA intersection_of: RO:0002162 NCBITaxon:9606 ! in taxon Homo sapiens relationship: CL:4030046 PR:000001013 ! lacks_plasma_membrane_part integrin alpha-X relationship: RO:0002104 PR:000001865 ! has plasma membrane part interleukin-3 receptor class 2 alpha chain property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0001059 name: common myeloid progenitor, CD34-positive def: "A progenitor cell committed to myeloid lineage, including the megakaryocyte and erythroid lineages. These cells are CD34-positive, and express Gata1, Gata2, C/EBPa, and Pu.1." [GOC:add, GOC:dsd, GOC:tfm, ISBN:0878932437, PMCID:PMC2212039, PMID:10724173, PMID:16551251, PMID:16647566] comment: CMP are reportedly CD16-positive, CD32-positive, CD38-positive, CD45RA-negative, CD110-negative, CD117-positive, CD123-positive, and SCA1-negative. subset: human_subset subset: mouse_subset synonym: "CFU-GEMM" RELATED OMO:0003000 [ISBN:0878932437] synonym: "CFU-S" RELATED OMO:0003000 [ISBN:0878932437] synonym: "CMP" RELATED OMO:0003000 [ISBN:0878932437] synonym: "colony forming unit granulocyte, erythrocyte, macrophage, and megakaryocyte" RELATED [ISBN:0878932437] synonym: "common myeloid precursor, CD34-positive" EXACT [] synonym: "multipotential myeloid stem cell" RELATED [ISBN:0878932437] synonym: "myeloid stem cell" RELATED [ISBN:0878932437] synonym: "pluripotent stem cell (bone marrow)" RELATED [ISBN:0878932437] is_a: CL:0000049 ! common myeloid progenitor is_a: CL:0011026 ! progenitor cell intersection_of: CL:0000049 ! common myeloid progenitor intersection_of: BFO:0000051 PR:000001944 ! has part transcription factor PU.1 intersection_of: BFO:0000051 PR:000005307 ! has part CCAAT/enhancer-binding protein alpha intersection_of: BFO:0000051 PR:000007857 ! has part erythroid transcription factor intersection_of: BFO:0000051 PR:000007858 ! has part endothelial transcription factor GATA-2 intersection_of: RO:0002104 PR:000001003 ! has plasma membrane part CD34 molecule intersection_of: RO:0002215 GO:0002573 ! capable of myeloid leukocyte differentiation intersection_of: RO:0002215 GO:0043011 ! capable of myeloid dendritic cell differentiation relationship: BFO:0000051 PR:000001944 ! has part transcription factor PU.1 relationship: BFO:0000051 PR:000005307 ! has part CCAAT/enhancer-binding protein alpha relationship: BFO:0000051 PR:000007857 ! has part erythroid transcription factor relationship: BFO:0000051 PR:000007858 ! has part endothelial transcription factor GATA-2 relationship: RO:0002104 PR:000001003 ! has plasma membrane part CD34 molecule relationship: RO:0002215 GO:0043011 ! capable of myeloid dendritic cell differentiation [Term] id: CL:0001060 name: hematopoietic oligopotent progenitor cell, lineage-negative def: "A hematopoietic oligopotent progenitor cell that has the ability to differentiate into limited cell types but lacks lineage cell markers and self renewal capabilities. Cell lacks hematopoeitic lineage markers." [GOC:tfm, PMID:19022770] subset: human_subset subset: mouse_subset is_a: CL:0002032 ! hematopoietic oligopotent progenitor cell intersection_of: CL:0002032 ! hematopoietic oligopotent progenitor cell intersection_of: CL:4030046 PR:000001002 ! lacks_plasma_membrane_part CD19 molecule intersection_of: CL:4030046 PR:000001004 ! lacks_plasma_membrane_part CD4 molecule intersection_of: CL:4030046 PR:000001012 ! lacks_plasma_membrane_part integrin alpha-M intersection_of: CL:4030046 PR:000001020 ! lacks_plasma_membrane_part CD3 epsilon intersection_of: CL:4030046 PR:000001024 ! lacks_plasma_membrane_part neural cell adhesion molecule 1 intersection_of: CL:4030046 PR:000001083 ! lacks_plasma_membrane_part CD2 molecule intersection_of: CL:4030046 PR:000001084 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD8 alpha chain intersection_of: CL:4030046 PR:000001289 ! lacks_plasma_membrane_part membrane-spanning 4-domains subfamily A member 1 intersection_of: CL:4030046 PR:000001839 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD5 intersection_of: CL:4030046 PR:000001889 ! lacks_plasma_membrane_part CD14 molecule intersection_of: CL:4030046 PR:000002978 ! lacks_plasma_membrane_part lymphocyte antigen 6G intersection_of: CL:4030046 PR:000002981 ! lacks_plasma_membrane_part lymphocyte antigen 76 (mouse) intersection_of: RO:0000053 PATO:0001401 ! has characteristic oligopotent relationship: CL:4030046 PR:000001002 ! lacks_plasma_membrane_part CD19 molecule relationship: CL:4030046 PR:000001004 ! lacks_plasma_membrane_part CD4 molecule relationship: CL:4030046 PR:000001012 ! lacks_plasma_membrane_part integrin alpha-M relationship: CL:4030046 PR:000001020 ! lacks_plasma_membrane_part CD3 epsilon relationship: CL:4030046 PR:000001024 ! lacks_plasma_membrane_part neural cell adhesion molecule 1 relationship: CL:4030046 PR:000001083 ! lacks_plasma_membrane_part CD2 molecule relationship: CL:4030046 PR:000001084 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD8 alpha chain relationship: CL:4030046 PR:000001289 ! lacks_plasma_membrane_part membrane-spanning 4-domains subfamily A member 1 relationship: CL:4030046 PR:000001839 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD5 relationship: CL:4030046 PR:000001889 ! lacks_plasma_membrane_part CD14 molecule relationship: CL:4030046 PR:000002978 ! lacks_plasma_membrane_part lymphocyte antigen 6G relationship: CL:4030046 PR:000002981 ! lacks_plasma_membrane_part lymphocyte antigen 76 (mouse) property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-01-06T03:43:27Z [Term] id: CL:0001061 name: abnormal cell def: "A cell found in an organism or derived from an organism exhibiting a phenotype that deviates from the expected phenotype of any native cell type of that organism. Abnormal cells are typically found in disease states or disease models." [GOC:add, GOC:cg, GOC:wdd] comment: https://github.com/obophenotype/cell-ontology/issues/448 subset: cellxgene_subset subset: human_subset subset: mouse_subset xref: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C12913 is_a: CL:0000000 ! cell intersection_of: CL:0000000 ! cell intersection_of: RO:0000053 PATO:0000460 ! has characteristic abnormal relationship: RO:0000053 PATO:0000460 ! has characteristic abnormal property_value: terms:contributor https://orcid.org/0000-0001-9990-8331 property_value: terms:date "2017-01-30T18:53:32Z" xsd:dateTime [Term] id: CL:0001062 name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated def: "A CD8-positive, alpha beta memory T cell with the phenotype CD45RA-positive, CD45RO-negative, and CCR7-negative." [GOC:add, GOC:dos, PMID:15032595, PMID:16237082, PMID:26883338] comment: This cell type is seen in human but not found in the mouse. subset: cellxgene_subset subset: human_reference_atlas subset: human_subset synonym: "CD8+ TEMRA" EXACT [PMID:15032595] synonym: "CD8-positive TEMRA" EXACT [PMID:15032595] synonym: "TEMRA" BROAD [PMID:15032595] is_a: CL:0000909 ! CD8-positive, alpha-beta memory T cell is_a: CL:4030002 ! effector memory CD45RA-positive, alpha-beta T cell, terminally differentiated intersection_of: CL:0000909 ! CD8-positive, alpha-beta memory T cell intersection_of: CL:4030046 PR:000001017 ! lacks_plasma_membrane_part receptor-type tyrosine-protein phosphatase C isoform CD45RO intersection_of: CL:4030046 PR:000001203 ! lacks_plasma_membrane_part C-C chemokine receptor type 7 intersection_of: RO:0002104 PR:000001015 ! has plasma membrane part receptor-type tyrosine-protein phosphatase C isoform CD45RA intersection_of: RO:0002162 NCBITaxon:9606 ! in taxon Homo sapiens intersection_of: RO:0002353 GO:0043379 ! output of memory T cell differentiation relationship: CL:4030046 PR:000001017 ! lacks_plasma_membrane_part receptor-type tyrosine-protein phosphatase C isoform CD45RO relationship: CL:4030046 PR:000001203 ! lacks_plasma_membrane_part C-C chemokine receptor type 7 relationship: RO:0002104 PR:000001015 ! has plasma membrane part receptor-type tyrosine-protein phosphatase C isoform CD45RA relationship: RO:0002202 CL:0000913 ! develops from effector memory CD8-positive, alpha-beta T cell property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0001063 name: neoplastic cell def: "An abnormal cell exhibiting dysregulation of cell proliferation or programmed cell death and capable of forming a neoplasm, an aggregate of cells in the form of a tumor mass or an excess number of abnormal cells (liquid tumor) within an organism." [GOC:add, GOC:cg, GOC:wdd] comment: https://github.com/obophenotype/cell-ontology/issues/448 subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "tumor cell" RELATED [] synonym: "tumour cell" RELATED [] xref: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C12922 is_a: CL:0001061 ! abnormal cell intersection_of: CL:0001061 ! abnormal cell intersection_of: RO:0000053 PATO:0002011 ! has characteristic neoplastic relationship: RO:0000053 PATO:0002011 ! has characteristic neoplastic property_value: terms:contributor https://orcid.org/0000-0001-9990-8331 property_value: terms:date "2017-01-30T19:16:26Z" xsd:dateTime [Term] id: CL:0001064 name: malignant cell def: "A neoplastic cell that is capable of entering a surrounding tissue" [GOC:add, GOC:cg, GOC:wdd] comment: https://github.com/obophenotype/cell-ontology/issues/448 subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "cancer cell" RELATED [] xref: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C12917 is_a: CL:0001063 ! neoplastic cell intersection_of: CL:0001063 ! neoplastic cell intersection_of: RO:0000053 PATO:0002097 ! has characteristic neoplastic, malignant relationship: RO:0000053 PATO:0002097 ! has characteristic neoplastic, malignant property_value: terms:contributor https://orcid.org/0000-0001-9990-8331 property_value: terms:date "2017-01-30T19:39:12Z" xsd:dateTime [Term] id: CL:0001065 name: innate lymphoid cell def: "A lymphocyte that lacks characteristic T cell, B cell, myeloid cell, and dendritic cell markers, that functions as part of the innate immune response to produce cytokines and other effector responses." [GOC:add, GOC:dsd, PMID:23292121, PMID:23348417] subset: blood_and_immune_upper_slim subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset is_a: CL:0000542 ! lymphocyte intersection_of: CL:0000542 ! lymphocyte intersection_of: CL:4030046 PR:000001002 ! lacks_plasma_membrane_part CD19 molecule intersection_of: CL:4030046 PR:000001020 ! lacks_plasma_membrane_part CD3 epsilon intersection_of: RO:0002215 GO:0001816 ! capable of cytokine production intersection_of: RO:0002215 GO:0045087 ! capable of innate immune response relationship: CL:4030046 PR:000001002 ! lacks_plasma_membrane_part CD19 molecule relationship: CL:4030046 PR:000001020 ! lacks_plasma_membrane_part CD3 epsilon relationship: RO:0002215 GO:0001816 ! capable of cytokine production relationship: RO:0002215 GO:0045087 ! capable of innate immune response property_value: RO:0002175 NCBITaxon:9606 property_value: terms:contributor https://orcid.org/0000-0001-9990-8331 property_value: terms:date "2017-01-30T20:20:48Z" xsd:dateTime [Term] id: CL:0001066 name: erythroid progenitor cell, mammalian def: "A progenitor cell committed to the erythroid lineage. This cell is ter119-positive but lacks expression of other hematopoietic lineage markers (lin-negative)." [GOC:add, ISBN:0721601464] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "BFU-E" RELATED OMO:0003000 [] synonym: "blast forming unit erythroid" RELATED [] synonym: "burst forming unit erythroid" RELATED [] synonym: "CFU-E" RELATED OMO:0003000 [] synonym: "colony forming unit erythroid" RELATED [] synonym: "erythroid stem cell" RELATED [] xref: BTO:0004911 is_a: CL:0000038 ! erythroid progenitor cell intersection_of: CL:0000038 ! erythroid progenitor cell intersection_of: CL:4030046 PR:000001002 ! lacks_plasma_membrane_part CD19 molecule intersection_of: CL:4030046 PR:000001004 ! lacks_plasma_membrane_part CD4 molecule intersection_of: CL:4030046 PR:000001012 ! lacks_plasma_membrane_part integrin alpha-M intersection_of: CL:4030046 PR:000001020 ! lacks_plasma_membrane_part CD3 epsilon intersection_of: CL:4030046 PR:000001024 ! lacks_plasma_membrane_part neural cell adhesion molecule 1 intersection_of: CL:4030046 PR:000001083 ! lacks_plasma_membrane_part CD2 molecule intersection_of: CL:4030046 PR:000001084 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD8 alpha chain intersection_of: CL:4030046 PR:000001289 ! lacks_plasma_membrane_part membrane-spanning 4-domains subfamily A member 1 intersection_of: CL:4030046 PR:000001839 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD5 intersection_of: CL:4030046 PR:000001889 ! lacks_plasma_membrane_part CD14 molecule intersection_of: CL:4030046 PR:000002978 ! lacks_plasma_membrane_part lymphocyte antigen 6G intersection_of: RO:0002104 PR:000001945 ! has plasma membrane part transferrin receptor protein 1 intersection_of: RO:0002215 GO:0030218 ! capable of erythrocyte differentiation relationship: CL:4030046 PR:000001002 ! lacks_plasma_membrane_part CD19 molecule relationship: CL:4030046 PR:000001004 ! lacks_plasma_membrane_part CD4 molecule relationship: CL:4030046 PR:000001012 ! lacks_plasma_membrane_part integrin alpha-M relationship: CL:4030046 PR:000001020 ! lacks_plasma_membrane_part CD3 epsilon relationship: CL:4030046 PR:000001024 ! lacks_plasma_membrane_part neural cell adhesion molecule 1 relationship: CL:4030046 PR:000001083 ! lacks_plasma_membrane_part CD2 molecule relationship: CL:4030046 PR:000001084 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD8 alpha chain relationship: CL:4030046 PR:000001289 ! lacks_plasma_membrane_part membrane-spanning 4-domains subfamily A member 1 relationship: CL:4030046 PR:000001839 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD5 relationship: CL:4030046 PR:000001889 ! lacks_plasma_membrane_part CD14 molecule relationship: CL:4030046 PR:000002978 ! lacks_plasma_membrane_part lymphocyte antigen 6G relationship: RO:0002104 PR:000001945 ! has plasma membrane part transferrin receptor protein 1 relationship: RO:0002215 GO:0030218 ! capable of erythrocyte differentiation property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0001066" xsd:string {name="erythroid progenitor cell, mammalian on CELLxGENE CellGuide"} property_value: terms:description "Erythroid progenitor cells serve as precursors for mature erythrocytes. These cells sit at a critical juncture in the erythroid lineage, representing the stage of commitment to producing red blood cells. As such, erythroid progenitor cells are a central element in hematopoiesis, the process by which the body replenishes its supply of blood cells. This production occurs primarily in the bone marrow, where erythroid progenitor cells multiply and differentiate into mature erythrocytes.\nHematopoietic stem cells give rise to the multipotent progenitor (MPP), followed by the common myeloid progenitor (CMP), which further commits to the megakaryocyte-erythroid progenitor (MEP). Commitment to the erythroid lineage proceeds with the burst-forming unit-erythroid (BFU-E), which further differentiates into the colony-forming unit-erythroid (CFU-E), also referred to as the erythroid progenitor cell.\nErythroid progenitor cells embark on a journey of progressive maturation marked by cellular changes such as reduced cell size, increased cell density, condensed chromatin structure, and hemoglobin accumulation. The final stages of this maturation process leads to loss of the cell nucleus and the acquisition of the characteristic biconcave shape. This process is tightly regulated through a combination of various growth factors, cytokines, and hormones, the most critical of which is erythropoietin. Aberrations in the differentiation and maturation of these progenitor cells can result in blood diseases such as anemia and polycythemia.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1002/stem.2834", xref="DOI:10.1016/B978-0-323-04404-2.10002-8", xref="DOI:10.1083/jcb.96.2.386", xref="DOI:10.1097/MOH.0000000000000328"} [Term] id: CL:0001067 name: group 1 innate lymphoid cell def: "An innate lymphoid cell that is capable of producing the type 1 cytokine IFN-gamma, but not Th2 or Th17 cell-associated cytokines." [GOC:add, GOC:dsd, PMID:23348417] subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset is_a: CL:0001065 ! innate lymphoid cell intersection_of: CL:0001065 ! innate lymphoid cell intersection_of: RO:0002215 GO:0032609 ! capable of type II interferon production relationship: RO:0002215 GO:0032609 ! capable of type II interferon production property_value: RO:0002175 NCBITaxon:9606 property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0001067" xsd:string {name="group 1 innate lymphoid cell on CELLxGENE CellGuide"} property_value: terms:contributor https://orcid.org/0000-0001-9990-8331 property_value: terms:date "2017-01-30T20:42:44Z" xsd:dateTime property_value: terms:description "Group 1 Innate lymphoid cells (ILC1s) are one of five subsets of innate lymphoid cells (ILCs). ILC1s are largely tissue-resident cells and express the transcription factor T-bet and predominantly produce the cytokine interferon-gamma (IFN-γ). ILC1s initially included natural killer (NK) cells and T-bet+ ILC1s, but a 2018 update to the nomenclature proposed to further separate these two cell types based upon differences in development and function. However, it can be difficult to distinguish between these cell types.\nILC1s are non-cytotoxic or weakly cytotoxic, expressing relatively low levels of perforin, and play an important role in the response to viruses, certain intracellular bacteria and parasites, and fungi. Their release of IFN-γ and tumor necrosis factor (TNF) further shapes the adaptive immune response. Their functionality mirrors Th1 helper cells.\nWhile ILC1s have been shown to be important in the response to infections, ILC1s have also been demonstrated to accumulate in inflammatory diseases such as Crohn’s disease, chronic obstructive pulmonary disease, and rheumatoid arthritis.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1002/eji.201747294", xref="DOI:10.1016/j.cell.2018.07.017", xref="DOI:10.1038/nature14189", xref="DOI:10.1038/nri.2017.86", xref="DOI:10.1101/cshperspect.a030304"} [Term] id: CL:0001068 name: ILC1 def: "A group 1 innate lymphoid cell that is non-cytotoxic." [GOC:add, GOC:dsd, PMID:23292121, PMID:23348417] subset: human_subset subset: mouse_subset is_a: CL:0001067 ! group 1 innate lymphoid cell property_value: terms:contributor https://orcid.org/0000-0001-9990-8331 property_value: terms:date "2017-01-30T20:54:12Z" xsd:dateTime [Term] id: CL:0001069 name: group 2 innate lymphoid cell def: "An innate lymphoid cell that is capable of producing T-helper 2-cell associated cytokines upon stimulation." [GOC:add, GOC:dsd, PMID:23292121, PMID:23562755] subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "ILC2" EXACT [] synonym: "natural helper cell" EXACT [] synonym: "nuocyte" EXACT [] is_a: CL:0001065 ! innate lymphoid cell intersection_of: CL:0001065 ! innate lymphoid cell intersection_of: RO:0002215 GO:0032634 ! capable of interleukin-5 production relationship: RO:0002215 GO:0032634 ! capable of interleukin-5 production property_value: RO:0002175 NCBITaxon:9606 property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0001069" xsd:string {name="group 2 innate lymphoid cell on CELLxGENE CellGuide"} property_value: terms:contributor https://orcid.org/0000-0001-9990-8331 property_value: terms:date "2017-01-30T21:20:08Z" xsd:dateTime property_value: terms:description "Group 2 innate lymphoid cells, also known as ILC2 cells, are a subset of the innate lymphoid cell family - a family of immune cells crucial for host defense, immune regulation, and tissue repair especially in the context of infections and inflammatory conditions. These cells are largely tissue-resident, predominantly residing in barrier tissues such as the skin, lungs, and gastrointestinal tract. ILC2s are defined by their expression and reliance on the GATA3 transcription factor.\nILC2 cells play a significant role in the immune response, especially against parasitic infections and in allergic responses and autoimmune disorders. They predominantly produce type 2 cytokines including interleukin-5 (IL-5) and interleukin-13 (IL-13) in response to stimuli such as cytokines IL-25 and IL-33, which are often produced by epithelial cells in response to tissue damage. IL-5 is crucial for eosinophil activation, a component of the immune system that plays a key role in combating parasitic infections. Concurrently, IL-13 helps in expelling parasites from the body's system, as well as enforcing barrier integrity.\nILC2s are also instrumental in tissue repair and homeostasis. They help in maintaining body metabolism and fat storage, largely by producing a hormone known as methionine-enkephalin peptides. ILC2 cells also aid in early tissue repair processes, by the secretion of amphiregulin, a growth factor. Despite their protective functions, ILC2 cells can also contribute to pathologies such as asthma and other inflammatory diseases if their actions are not properly regulated.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1002/eji.201747294", xref="DOI:10.1016/j.cell.2018.07.017", xref="DOI:10.1038/nature14189", xref="DOI:10.1038/nri.2017.86", xref="DOI:10.1101/cshperspect.a030304"} [Term] id: CL:0001070 name: beige adipocyte def: "An adipocyte that is beige in color, thermogenic, and which differentiates in white fat tissue from a Myf5-negative progenitor." [GOC:add, GOC:cvs, GOC:ymb, PMID:22796012, PMID:25851693] subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "beige brown adipocyte" EXACT [] synonym: "beige fat cell" EXACT [] synonym: "beige/brite adipocyte" EXACT [] synonym: "brite adipocyte" EXACT [] synonym: "brite cell" EXACT [] synonym: "brite fat cell" EXACT [] xref: MESH:D000069797 is_a: CL:0000136 ! adipocyte relationship: BFO:0000050 UBERON:0001347 ! part of white adipose tissue property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/2d-ftu/thymus-thymus-lobule/v1.3/assets/2d-ftu-thymus-thymus-lobule.png" xsd:string {terms:licence="http://creativecommons.org/licenses/by/4.0/", xref="doi:10.48539/HBM322.LZLG.752"} property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0001071 name: group 3 innate lymphoid cell def: "An innate lymphoid cell that constituitively expresses RORgt and is capable of expressing IL17A and/or IL-22." [GOC:add, GOC:dsd, PMID:23292121, PMID:23348417] subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "ILC3" EXACT [] is_a: CL:0001065 ! innate lymphoid cell intersection_of: CL:0001065 ! innate lymphoid cell intersection_of: BFO:0000051 PR:000003455 ! has part nuclear receptor ROR-gamma isoform 2 relationship: BFO:0000051 PR:000003455 ! has part nuclear receptor ROR-gamma isoform 2 property_value: RO:0002175 NCBITaxon:9606 property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0001071" xsd:string {name="group 3 innate lymphoid cell on CELLxGENE CellGuide"} property_value: terms:contributor https://orcid.org/0000-0001-9990-8331 property_value: terms:date "2017-01-31T20:21:26Z" xsd:dateTime property_value: terms:description "Group 3 innate lymphoid cells (ILC3) belong to the family of innate lymphoid cells. They share a high degree of similarity with T lymphocytes, particularly in terms of their transcriptional program and their cytokine production profiles, but lack the antigen-specific receptors that characterize adaptive immune cells. Originating from common lymphoid progenitors, ILC3s are typically found in mucosal tissues and are especially prevalent in the gastrointestinal tract. The grouping of ILC3s originally included lymphoid tissue inducer (LTi) cells, which have more recently been categorized separately.\nILC3s play an important homeostatic role in the gastrointestinal tract, contributing to mucosal barrier integrity, lymphoid organogenesis, and controlling the balance between tolerance and immunity to commensal and pathogenic bacteria, respectively. The protective role of ILC3s primarily stems from their capacity to respond to signals of microbial invasion or tissue damage, releasing an array of cytokines such as Interleukin-22 (IL-22) and Interleukin-17 (IL-17) which are dependent upon the RORγt transcription factor. These cytokines in turn mediate protective responses including the enhancement of epithelial barrier function, the promotion of tissue repair, and the control of bacterial infection.\nHowever, ILC3s can also contribute to the development of inflammatory diseases such as inflammatory bowel disease (IBD) and psoriasis. Therefore, studies have also emphasized the importance of regulatory mechanisms controlling ILC3 activation, providing novel insights into the complexity of immune regulation in maintaining tissue homeostasis.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1002/eji.201747294", xref="DOI:10.1016/j.cell.2018.07.017", xref="DOI:10.1038/nature14189", xref="DOI:10.1038/nri.2017.86", xref="DOI:10.1101/cshperspect.a030304"} [Term] id: CL:0001072 name: CD34-negative, CD117-positive innate lymphoid cell, human def: "An innate lymphoid cell in the human with the phenotype CD34-negative, CD117-positive, and a precusor to NK cells, ILC2 cells, and ILC3 cells." [GOC:add, PMID:30193847, PMID:31201208] subset: cellxgene_subset subset: human_subset synonym: "CD34-negative, CD117-positive ILC" EXACT [] synonym: "CD34-negative, CD117-positive ILCP" EXACT [] synonym: "CD34-negative, CD117-positive innate lymphoid cell precusor" EXACT [] is_a: CL:0001082 ! immature innate lymphoid cell intersection_of: CL:0001065 ! innate lymphoid cell intersection_of: CL:4030046 PR:P28906 ! lacks_plasma_membrane_part hematopoietic progenitor cell antigen CD34 (human) intersection_of: RO:0000053 PATO:0001501 ! has characteristic immature intersection_of: RO:0002104 PR:P10721 ! has plasma membrane part mast/stem cell growth factor receptor Kit (human) intersection_of: RO:0002162 NCBITaxon:9606 ! in taxon Homo sapiens relationship: CL:4030046 PR:P28906 ! lacks_plasma_membrane_part hematopoietic progenitor cell antigen CD34 (human) relationship: RO:0002104 PR:P10721 ! has plasma membrane part mast/stem cell growth factor receptor Kit (human) relationship: RO:0002202 CL:0001074 ! develops from CD34-positive, CD56-positive, CD117-positive common innate lymphoid precursor, human [Term] id: CL:0001073 name: CD34-negative, CD56-positive, CD117-positive innate lymphoid cell, human def: "An innate lymphoid cell in the human with the phenotype CD34-negative, CD56-positive, CD117-positive.Thie cell type may include precusors to NK cells and ILC3 cells." [GOC:add, PMID:30193847, PMID:31201208] subset: human_subset synonym: "CD34-negative, CD56-positive, CD117-positive ILC" EXACT [] synonym: "CD34-negative, CD56-positive, CD117-positive ILCP" EXACT [] synonym: "CD34-negative, CD56-positive, CD117-positive innate lymphoid cell precursor" EXACT [] is_a: CL:0001072 ! CD34-negative, CD117-positive innate lymphoid cell, human intersection_of: CL:0001072 ! CD34-negative, CD117-positive innate lymphoid cell, human intersection_of: RO:0002104 PR:P10721 ! has plasma membrane part mast/stem cell growth factor receptor Kit (human) intersection_of: RO:0002104 PR:P13591 ! has plasma membrane part neural cell adhesion molecule 1 (human) intersection_of: RO:0002162 NCBITaxon:9606 ! in taxon Homo sapiens relationship: RO:0002104 PR:P13591 ! has plasma membrane part neural cell adhesion molecule 1 (human) [Term] id: CL:0001074 name: CD34-positive, CD56-positive, CD117-positive common innate lymphoid precursor, human def: "An innate lymphoid cell precursor in the human with the phenotype CD34-positive, CD56-positive, CD117-positive.Thie cell type may include precusors to NK cells and ILC3 cells." [GOC:add, PMID:30193847] subset: cellxgene_subset subset: human_subset synonym: "CD34-positive, CD56-positive, CD117-positive CILP" EXACT [] is_a: CL:0001082 ! immature innate lymphoid cell intersection_of: CL:0001065 ! innate lymphoid cell intersection_of: RO:0000053 PATO:0001501 ! has characteristic immature intersection_of: RO:0002104 PR:P10721 ! has plasma membrane part mast/stem cell growth factor receptor Kit (human) intersection_of: RO:0002104 PR:P13591 ! has plasma membrane part neural cell adhesion molecule 1 (human) intersection_of: RO:0002104 PR:P28906 ! has plasma membrane part hematopoietic progenitor cell antigen CD34 (human) intersection_of: RO:0002162 NCBITaxon:9606 ! in taxon Homo sapiens relationship: RO:0002104 PR:P10721 ! has plasma membrane part mast/stem cell growth factor receptor Kit (human) relationship: RO:0002104 PR:P13591 ! has plasma membrane part neural cell adhesion molecule 1 (human) relationship: RO:0002104 PR:P28906 ! has plasma membrane part hematopoietic progenitor cell antigen CD34 (human) [Term] id: CL:0001075 name: KLRG1-positive innate lymphoid cell, human def: "An innate lymphoid cell in the human with the phenotype KLRG1-positive that is a precusor for ILC2 cells." [GOC:add, PMID:31201208] subset: human_subset synonym: "KLRG1-positive ILC" EXACT [] is_a: CL:0001072 ! CD34-negative, CD117-positive innate lymphoid cell, human intersection_of: CL:0001072 ! CD34-negative, CD117-positive innate lymphoid cell, human intersection_of: RO:0002104 PR:Q96E93 ! has plasma membrane part killer cell lectin-like receptor subfamily G member 1 (human) intersection_of: RO:0002162 NCBITaxon:9606 ! in taxon Homo sapiens relationship: RO:0002104 PR:Q96E93 ! has plasma membrane part killer cell lectin-like receptor subfamily G member 1 (human) [Term] id: CL:0001076 name: NKp46-positive innate lymphoid cell, human def: "An innate lymphoid cell in the human with the phenotype NKp46-positive that is a precusor for NK cells and ILC3 cells." [GOC:add, PMID:31201208, PMID:31337734] subset: cellxgene_subset subset: human_subset synonym: "NKp46-positive ILC" EXACT [] is_a: CL:0001074 ! CD34-positive, CD56-positive, CD117-positive common innate lymphoid precursor, human intersection_of: CL:0001074 ! CD34-positive, CD56-positive, CD117-positive common innate lymphoid precursor, human intersection_of: RO:0002104 PR:O76036 ! has plasma membrane part natural cytotoxicity triggering receptor 1 (human) intersection_of: RO:0002162 NCBITaxon:9606 ! in taxon Homo sapiens relationship: RO:0002104 PR:O76036 ! has plasma membrane part natural cytotoxicity triggering receptor 1 (human) [Term] id: CL:0001077 name: ILC1, human def: "An ILC1 cell in the human with the phenotype CD56-negative, IL-7Ralpha-positive, T-bet-positive." [GOC:add, PMID:31500958] subset: cellxgene_subset subset: human_subset synonym: "innate lymphoid cell 1, human" EXACT [] is_a: CL:0001068 ! ILC1 intersection_of: CL:0001068 ! ILC1 intersection_of: BFO:0000051 PR:Q9UL17 ! has part T-box transcription factor TBX21 (human) intersection_of: RO:0002104 PR:P16871 ! has plasma membrane part interleukin-7 receptor subunit alpha (human) intersection_of: RO:0002162 NCBITaxon:9606 ! in taxon Homo sapiens relationship: BFO:0000051 PR:Q9UL17 ! has part T-box transcription factor TBX21 (human) relationship: RO:0002104 PR:P16871 ! has plasma membrane part interleukin-7 receptor subunit alpha (human) [Term] id: CL:0001078 name: group 3 innate lymphoid cell, human def: "A group 3 innate lymphoid cell in the human with the phenotype IL-7Ralpha-positive." [GOC:add, PMID:31500958] subset: cellxgene_subset subset: human_reference_atlas subset: human_subset synonym: "ILC3, human" EXACT [] is_a: CL:0001071 ! group 3 innate lymphoid cell intersection_of: CL:0001071 ! group 3 innate lymphoid cell intersection_of: RO:0002104 PR:P16871 ! has plasma membrane part interleukin-7 receptor subunit alpha (human) intersection_of: RO:0002162 NCBITaxon:9606 ! in taxon Homo sapiens relationship: RO:0002104 PR:P16871 ! has plasma membrane part interleukin-7 receptor subunit alpha (human) property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0001079 name: NKp44-positive group 3 innate lymphoid cell, human def: "A group 3 innate lymphoid cell in the human with the phenotype IL-7Ralpha-positive, and NKp44-positive." [GOC:add, PMID:24778151, PMID:31500958] subset: cellxgene_subset subset: human_subset is_a: CL:0001078 ! group 3 innate lymphoid cell, human intersection_of: CL:0001071 ! group 3 innate lymphoid cell intersection_of: RO:0002104 PR:O95944 ! has plasma membrane part natural cytotoxicity triggering receptor 2 (human) intersection_of: RO:0002104 PR:P16871 ! has plasma membrane part interleukin-7 receptor subunit alpha (human) intersection_of: RO:0002162 NCBITaxon:9606 ! in taxon Homo sapiens relationship: RO:0002104 PR:O95944 ! has plasma membrane part natural cytotoxicity triggering receptor 2 (human) [Term] id: CL:0001080 name: NKp44-negative group 3 innate lymphoid cell, human def: "A group 3 innate lymphoid cell in the human with the phenotype IL-7Ralpha-positive, and NKp44-negative." [GOC:add, PMID:24778151, PMID:31500958] subset: cellxgene_subset subset: human_subset is_a: CL:0001078 ! group 3 innate lymphoid cell, human intersection_of: CL:0001071 ! group 3 innate lymphoid cell intersection_of: CL:4030046 PR:O95944 ! lacks_plasma_membrane_part natural cytotoxicity triggering receptor 2 (human) intersection_of: RO:0002104 PR:P16871 ! has plasma membrane part interleukin-7 receptor subunit alpha (human) intersection_of: RO:0002162 NCBITaxon:9606 ! in taxon Homo sapiens relationship: CL:4030046 PR:O95944 ! lacks_plasma_membrane_part natural cytotoxicity triggering receptor 2 (human) [Term] id: CL:0001081 name: group 2 innate lymphoid cell, human def: "A group 2 innate lymphoid cell in the human with the phenotype CD25-positive, CD127-positive, CD161-positive, and GATA-3-positive." [GOC:add, PMID:24778151, PMID:26844414] subset: cellxgene_subset subset: human_subset synonym: "ILC2, human" EXACT [] is_a: CL:0001069 ! group 2 innate lymphoid cell intersection_of: CL:0001069 ! group 2 innate lymphoid cell intersection_of: BFO:0000051 PR:P23771 ! has part trans-acting T-cell-specific transcription factor GATA-3 (human) intersection_of: RO:0002104 PR:P01589 ! has plasma membrane part interleukin-2 receptor subunit alpha (human) intersection_of: RO:0002104 PR:P16871 ! has plasma membrane part interleukin-7 receptor subunit alpha (human) intersection_of: RO:0002104 PR:Q12918 ! has plasma membrane part killer cell lectin-like receptor subfamily B member 1 (human) intersection_of: RO:0002104 PR:Q9Y5Y4 ! has plasma membrane part prostaglandin D2 receptor 2 (human) intersection_of: RO:0002162 NCBITaxon:9606 ! in taxon Homo sapiens relationship: BFO:0000051 PR:P23771 ! has part trans-acting T-cell-specific transcription factor GATA-3 (human) relationship: RO:0002104 PR:P01589 ! has plasma membrane part interleukin-2 receptor subunit alpha (human) relationship: RO:0002104 PR:P16871 ! has plasma membrane part interleukin-7 receptor subunit alpha (human) relationship: RO:0002104 PR:Q12918 ! has plasma membrane part killer cell lectin-like receptor subfamily B member 1 (human) relationship: RO:0002104 PR:Q9Y5Y4 ! has plasma membrane part prostaglandin D2 receptor 2 (human) [Term] id: CL:0001082 name: immature innate lymphoid cell def: "An innate lyphoid cell with an immature phenotype." [GOC:add] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "immature ILC" EXACT [] is_a: CL:0001065 ! innate lymphoid cell intersection_of: CL:0001065 ! innate lymphoid cell intersection_of: RO:0000053 PATO:0001501 ! has characteristic immature relationship: RO:0000053 PATO:0001501 ! has characteristic immature property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0001082" xsd:string {name="immature innate lymphoid cell on CELLxGENE CellGuide"} property_value: terms:description "The immature innate lymphoid cell (ILC) refers to a stage in the development of the innate lymphoid cell, a type of immune cell that plays a pivotal role in the innate immune response. These cells are derived from common lymphoid progenitors and are primarily found in the bone marrow. During their immature stage, they possess the potential to differentiate into various mature innate lymphoid cell subsets that contribute to immune responses.\nImmature Innate Lymphoid Cells are characterized by their lack of antigen specificity, which distinguishes them from adaptive immune cells such as B and T lymphocytes. While they do not have antigen-specific receptors, they are programmed to respond to certain groups of pathogens or cytokine signaling. Immature ILCs display limited effector functions; however, they are critical in the development of effective innate immune responses as they give rise to the diverse array of mature ILC subsets.\nThe ILC precursors develop from the fetal liver and the adult bone marrow and, depending upon the transcription factors involved, will give rise to unipotent ILC precursors which then give rise to mature ILC subsets. ILC subsets consist of natural killer (NK), ILC1, ILC2, ILC3, and lymphoid tissue inducer (LTi) cells, each having unique functions in immunity.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1002/eji.201747294", xref="DOI:10.1016/j.cell.2018.07.017", xref="DOI:10.1038/nature14189", xref="DOI:10.1038/nri.2017.86", xref="DOI:10.1101/cshperspect.a030304"} [Term] id: CL:0001087 name: effector memory CD4-positive, alpha-beta T cell, terminally differentiated def: "A CD4-positive, alpha beta memory T cell with the phenotype CD45RA-positive, CD45RO-negative, and CCR7-negative." [GOC:add, PMID:17465678, PMID:26883338, PMID:27997758, PMID:29133794] comment: This cell type is seen in human but not found in the mouse. subset: cellxgene_subset subset: human_reference_atlas subset: human_subset synonym: "CD4+ TEMRA" EXACT [PMID:17465678] synonym: "CD4-positive TEMRA" EXACT [PMID:17465678] synonym: "TEMRA" BROAD [PMID:17465678] is_a: CL:0000897 ! CD4-positive, alpha-beta memory T cell is_a: CL:4030002 ! effector memory CD45RA-positive, alpha-beta T cell, terminally differentiated intersection_of: CL:0000897 ! CD4-positive, alpha-beta memory T cell intersection_of: CL:4030046 PR:000001017 ! lacks_plasma_membrane_part receptor-type tyrosine-protein phosphatase C isoform CD45RO intersection_of: CL:4030046 PR:000001203 ! lacks_plasma_membrane_part C-C chemokine receptor type 7 intersection_of: RO:0002104 PR:000001015 ! has plasma membrane part receptor-type tyrosine-protein phosphatase C isoform CD45RA intersection_of: RO:0002162 NCBITaxon:9606 ! in taxon Homo sapiens intersection_of: RO:0002353 GO:0043379 ! output of memory T cell differentiation relationship: CL:4030046 PR:000001017 ! lacks_plasma_membrane_part receptor-type tyrosine-protein phosphatase C isoform CD45RO relationship: CL:4030046 PR:000001203 ! lacks_plasma_membrane_part C-C chemokine receptor type 7 relationship: RO:0002104 PR:000001015 ! has plasma membrane part receptor-type tyrosine-protein phosphatase C isoform CD45RA relationship: RO:0002202 CL:0000905 ! develops from effector memory CD4-positive, alpha-beta T cell property_value: RO:0002175 NCBITaxon:9606 property_value: terms:contributor https://orcid.org/0000-0001-9990-8331 property_value: terms:date "2021-01-18T16:32:44Z" xsd:dateTime [Term] id: CL:0001200 name: lymphocyte of B lineage, CD19-positive def: "A lymphocyte of B lineage that is CD19-positive." [GOC:add] comment: Types of B lineage lymphocytes include B cells and antibody secreting cells (plasmablasts and plasma cells). Lymphocytes of B cell lineage can be distinguished from those of T cell lineage by their lack of CD3e (as part of the T cell receptor complex). subset: human_subset subset: mouse_subset is_a: CL:0000945 ! lymphocyte of B lineage intersection_of: CL:0000945 ! lymphocyte of B lineage intersection_of: CL:4030046 PR:000001020 ! lacks_plasma_membrane_part CD3 epsilon intersection_of: RO:0002104 PR:000001002 ! has plasma membrane part CD19 molecule intersection_of: RO:0002162 NCBITaxon:40674 ! in taxon Mammalia relationship: CL:4030046 PR:000001020 ! lacks_plasma_membrane_part CD3 epsilon relationship: RO:0002104 PR:000001002 ! has plasma membrane part CD19 molecule relationship: RO:0002162 NCBITaxon:40674 ! in taxon Mammalia property_value: terms:contributor https://orcid.org/0000-0001-9990-8331 [Term] id: CL:0001201 name: B cell, CD19-positive def: "A B cell that is CD19-positive." [GOC:add] subset: human_subset subset: mouse_subset synonym: "B lymphocyte, CD19-positive" EXACT [] synonym: "B-cell, CD19-positive" EXACT [] synonym: "B-lymphocyte, CD19-positive" EXACT [] synonym: "CD19+ B cell" EXACT [] synonym: "CD19-positive B cell" EXACT [] is_a: CL:0000236 ! B cell is_a: CL:0001200 ! lymphocyte of B lineage, CD19-positive intersection_of: CL:0001200 ! lymphocyte of B lineage, CD19-positive intersection_of: RO:0002104 PR:000001002 ! has plasma membrane part CD19 molecule intersection_of: RO:0002215 GO:0019724 ! capable of B cell mediated immunity property_value: terms:contributor https://orcid.org/0000-0001-9990-8331 [Term] id: CL:0001202 name: CD86-positive plasmablast def: "A plasmablast that is CD86-positive." [GOC:add, PMID:20398308] subset: human_subset subset: mouse_subset synonym: "CD86+ plasmablast" EXACT [] synonym: "CD86-positive, CD20-negative plasmablast" BROAD [] is_a: CL:0000980 ! plasmablast intersection_of: CL:0000980 ! plasmablast intersection_of: RO:0002104 PR:000001412 ! has plasma membrane part CD86 molecule relationship: RO:0002104 PR:000001412 ! has plasma membrane part CD86 molecule property_value: terms:contributor https://orcid.org/0000-0001-9990-8331 [Term] id: CL:0001203 name: CD8-positive, alpha-beta memory T cell, CD45RO-positive def: "A CD8-positive, alpha-beta T cell with memory phenotype indicated by being CD45RO and CD127-positive. This cell type is also described as being CD25-negative, CD44-high, and CD122-high." [GO_REF:0000031, GOC:tfm, PMID:20146720] subset: cellxgene_subset subset: human_reference_atlas subset: human_subset synonym: "CD8-positive, alpha-beta memory T lymphocyte, CD45RO-positive" EXACT [] synonym: "CD8-positive, alpha-beta memory T-cell, CD45RO-positive" EXACT [] synonym: "CD8-positive, alpha-beta memory T-lymphocyte, CD45RO-positive" EXACT [] is_a: CL:0000909 {is_inferred="true"} ! CD8-positive, alpha-beta memory T cell intersection_of: CL:0000909 ! CD8-positive, alpha-beta memory T cell intersection_of: CL:4030046 PR:000001380 ! lacks_plasma_membrane_part interleukin-2 receptor subunit alpha intersection_of: RO:0002104 PR:000001017 ! has plasma membrane part receptor-type tyrosine-protein phosphatase C isoform CD45RO intersection_of: RO:0002104 PR:000001869 ! has plasma membrane part interleukin-7 receptor subunit alpha intersection_of: RO:0002162 NCBITaxon:9606 ! in taxon Homo sapiens intersection_of: RO:0002353 GO:0043379 ! output of memory T cell differentiation intersection_of: RO:0015015 PR:000001307 ! has high plasma membrane amount CD44 molecule intersection_of: RO:0015015 PR:000001381 ! has high plasma membrane amount interleukin-2 receptor subunit beta relationship: CL:4030046 PR:000001380 ! lacks_plasma_membrane_part interleukin-2 receptor subunit alpha relationship: RO:0002104 PR:000001017 ! has plasma membrane part receptor-type tyrosine-protein phosphatase C isoform CD45RO relationship: RO:0002104 PR:000001869 ! has plasma membrane part interleukin-7 receptor subunit alpha relationship: RO:0002162 NCBITaxon:9606 ! in taxon Homo sapiens relationship: RO:0002202 CL:0000906 ! develops from activated CD8-positive, alpha-beta T cell relationship: RO:0015015 PR:000001307 ! has high plasma membrane amount CD44 molecule relationship: RO:0015015 PR:000001381 ! has high plasma membrane amount interleukin-2 receptor subunit beta property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0001204 name: CD4-positive, alpha-beta memory T cell, CD45RO-positive def: "CD4-positive, alpha-beta long-lived T cell with the phenotype CD45RO-positive and CD127-positive. This cell type is also described as being CD25-negative, CD44-high, and CD122-high." [GO_REF:0000031, GOC:add, GOC:tfm, http://www.immgen.org/index_content.html, ISBN:0781735149] subset: human_subset synonym: "CD4-positive, alpha-beta memory T lymphocyte, CD45RO-positive" EXACT [] synonym: "CD4-positive, alpha-beta memory T-cell, CD45RO-positive" EXACT [] synonym: "CD4-positive, alpha-beta memory T-lymphocyte, CD45RO-positive" EXACT [] is_a: CL:0000897 {is_inferred="true"} ! CD4-positive, alpha-beta memory T cell intersection_of: CL:0000897 ! CD4-positive, alpha-beta memory T cell intersection_of: CL:4030046 PR:000001380 ! lacks_plasma_membrane_part interleukin-2 receptor subunit alpha intersection_of: RO:0002104 PR:000001017 ! has plasma membrane part receptor-type tyrosine-protein phosphatase C isoform CD45RO intersection_of: RO:0002104 PR:000001869 ! has plasma membrane part interleukin-7 receptor subunit alpha intersection_of: RO:0002162 NCBITaxon:9606 ! in taxon Homo sapiens intersection_of: RO:0002353 GO:0043379 ! output of memory T cell differentiation intersection_of: RO:0015015 PR:000001307 ! has high plasma membrane amount CD44 molecule intersection_of: RO:0015015 PR:000001381 ! has high plasma membrane amount interleukin-2 receptor subunit beta relationship: CL:4030046 PR:000001380 ! lacks_plasma_membrane_part interleukin-2 receptor subunit alpha relationship: RO:0002104 PR:000001017 ! has plasma membrane part receptor-type tyrosine-protein phosphatase C isoform CD45RO relationship: RO:0002104 PR:000001869 ! has plasma membrane part interleukin-7 receptor subunit alpha relationship: RO:0002162 NCBITaxon:9606 ! in taxon Homo sapiens relationship: RO:0002202 CL:0000896 ! develops from activated CD4-positive, alpha-beta T cell relationship: RO:0015015 PR:000001307 ! has high plasma membrane amount CD44 molecule relationship: RO:0015015 PR:000001381 ! has high plasma membrane amount interleukin-2 receptor subunit beta [Term] id: CL:0001658 name: visual pigment cell (sensu Nematoda and Protostomia) xref: FBbt:00004230 {sssom:mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"} is_a: CL:0000149 ! visual pigment cell is_a: CL:0000341 ! pigment cell (sensu Nematoda and Protostomia) [Term] id: CL:0002000 name: Kit-positive erythroid progenitor cell def: "An erythroid progenitor cell is Kit-positive, Ly6A-negative, CD41-negative, CD127-negative, and CD123-negative. This cell type is also described as being lin-negative, Kit-positive, CD150-negative, CD41-negative, CD105-positive, and FcgR-negative." [GOC:ak, GOC:tfm, http://www.immgen.org/index_content.html, PMID:19805084] comment: Markers found on mouse cells. subset: human_subset subset: mouse_subset synonym: "c- Kit-positive erythroid progenitor cell" EXACT [] is_a: CL:0001066 {is_inferred="true"} ! erythroid progenitor cell, mammalian intersection_of: CL:0001066 ! erythroid progenitor cell, mammalian intersection_of: CL:4030046 GO:0033001 ! lacks_plasma_membrane_part Fc-gamma receptor III complex intersection_of: CL:4030046 PR:000001833 ! lacks_plasma_membrane_part SLAM family member 1 intersection_of: CL:4030046 PR:000001865 ! lacks_plasma_membrane_part interleukin-3 receptor class 2 alpha chain intersection_of: CL:4030046 PR:000001869 ! lacks_plasma_membrane_part interleukin-7 receptor subunit alpha intersection_of: CL:4030046 PR:000002979 ! lacks_plasma_membrane_part lymphocyte antigen 6A-2/6E-1 intersection_of: CL:4030046 PR:000009127 ! lacks_plasma_membrane_part integrin alpha-IIb intersection_of: RO:0002104 PR:000001345 ! has plasma membrane part endoglin intersection_of: RO:0002104 PR:000002065 ! has plasma membrane part mast/stem cell growth factor receptor relationship: CL:4030046 GO:0033001 ! lacks_plasma_membrane_part Fc-gamma receptor III complex relationship: CL:4030046 PR:000001833 ! lacks_plasma_membrane_part SLAM family member 1 relationship: CL:4030046 PR:000001865 ! lacks_plasma_membrane_part interleukin-3 receptor class 2 alpha chain relationship: CL:4030046 PR:000001869 ! lacks_plasma_membrane_part interleukin-7 receptor subunit alpha relationship: CL:4030046 PR:000002979 ! lacks_plasma_membrane_part lymphocyte antigen 6A-2/6E-1 relationship: CL:4030046 PR:000009127 ! lacks_plasma_membrane_part integrin alpha-IIb relationship: RO:0002104 PR:000001345 ! has plasma membrane part endoglin relationship: RO:0002104 PR:000002065 ! has plasma membrane part mast/stem cell growth factor receptor relationship: RO:0002202 CL:0002006 ! develops from Kit-positive, CD34-negative megakaryocyte erythroid progenitor cell property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-04-26T10:14:16Z [Term] id: CL:0002001 name: CD34-positive, CD38-positive granulocyte monocyte progenitor def: "A granulocyte monocyte progenitor is CD34-positive, CD38-positive, IL-3receptor-alpha-positive and is CD45RA-negative." [GOC:tfm, PMID:12615892, PMID:19022770] comment: Markers are for human cells. According to different research groups, CD45RA is present or absent on this cell population. subset: human_subset subset: mouse_subset is_a: CL:0000557 {is_inferred="true"} ! granulocyte monocyte progenitor cell intersection_of: CL:0000557 ! granulocyte monocyte progenitor cell intersection_of: RO:0002104 PR:000001003 ! has plasma membrane part CD34 molecule intersection_of: RO:0002104 PR:000001408 ! has plasma membrane part ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 intersection_of: RO:0002104 PR:000001865 ! has plasma membrane part interleukin-3 receptor class 2 alpha chain relationship: RO:0002104 PR:000001003 ! has plasma membrane part CD34 molecule relationship: RO:0002104 PR:000001408 ! has plasma membrane part ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 relationship: RO:0002202 CL:0001026 ! develops from CD34-positive, CD38-positive common myeloid progenitor property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-01-13T03:19:22Z [Term] id: CL:0002002 name: Kit-positive granulocyte monocyte progenitor def: "A granulocyte monocyte progenitor that is Kit-positive, CD34-positive, Fc-gamma receptor II/II-positive, and is Sca-1-negative, Il7ra-negative, Cxc3r1-negative, and CD90-negative." [GOC:tfm, http://www.immgen.org/index_content.html, PMID:12615892, PMID:16322423, PMID:19022770, PMID:19273628] comment: Markers are found on mouse cells. subset: human_subset subset: mouse_subset is_a: CL:0000557 {is_inferred="true"} ! granulocyte monocyte progenitor cell intersection_of: CL:0000557 ! granulocyte monocyte progenitor cell intersection_of: CL:4030046 PR:000001206 ! lacks_plasma_membrane_part CX3C chemokine receptor 1 intersection_of: CL:4030046 PR:000001843 ! lacks_plasma_membrane_part Thy-1 membrane glycoprotein intersection_of: CL:4030046 PR:000001869 ! lacks_plasma_membrane_part interleukin-7 receptor subunit alpha intersection_of: CL:4030046 PR:000002979 ! lacks_plasma_membrane_part lymphocyte antigen 6A-2/6E-1 intersection_of: RO:0002104 PR:000001003 ! has plasma membrane part CD34 molecule intersection_of: RO:0002104 PR:000002065 ! has plasma membrane part mast/stem cell growth factor receptor intersection_of: RO:0015015 GO:0033001 ! has high plasma membrane amount Fc-gamma receptor III complex intersection_of: RO:0015015 PR:000001479 ! has high plasma membrane amount low affinity immunoglobulin gamma Fc region receptor II relationship: CL:4030046 PR:000001206 ! lacks_plasma_membrane_part CX3C chemokine receptor 1 relationship: CL:4030046 PR:000001843 ! lacks_plasma_membrane_part Thy-1 membrane glycoprotein relationship: CL:4030046 PR:000001869 ! lacks_plasma_membrane_part interleukin-7 receptor subunit alpha relationship: CL:4030046 PR:000002979 ! lacks_plasma_membrane_part lymphocyte antigen 6A-2/6E-1 relationship: RO:0002104 PR:000001003 ! has plasma membrane part CD34 molecule relationship: RO:0002104 PR:000002065 ! has plasma membrane part mast/stem cell growth factor receptor relationship: RO:0002202 CL:0001023 ! develops from Kit-positive, CD34-positive common myeloid progenitor relationship: RO:0015015 GO:0033001 ! has high plasma membrane amount Fc-gamma receptor III complex relationship: RO:0015015 PR:000001479 ! has high plasma membrane amount low affinity immunoglobulin gamma Fc region receptor II property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-01-13T03:19:28Z [Term] id: CL:0002003 name: CD34-positive, GlyA-negative erythroid progenitor cell def: "An erythroid progenitor cell that is CD34-positive and is GlyA-negative." [GOC:ak, GOC:tfm, PMID:19621348] comment: Cell markers associated with human cells. subset: human_subset subset: mouse_subset xref: FMA:83517 is_a: CL:0001066 {is_inferred="true"} ! erythroid progenitor cell, mammalian intersection_of: CL:0001066 ! erythroid progenitor cell, mammalian intersection_of: CL:4030046 PR:000001460 ! lacks_plasma_membrane_part glycophorin-A intersection_of: RO:0002104 PR:000001003 ! has plasma membrane part CD34 molecule relationship: CL:4030046 PR:000001460 ! lacks_plasma_membrane_part glycophorin-A relationship: RO:0002104 PR:000001003 ! has plasma membrane part CD34 molecule relationship: RO:0002202 CL:0002005 ! develops from CD34-positive, CD38-positive megakaryocyte erythroid progenitor cell property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-04-26T10:14:30Z [Term] id: CL:0002004 name: CD34-negative, GlyA-negative proerythroblast def: "A proerythoblast that is CD34-negative and GlyA-negative." [GOC:ak, GOC:tfm, PMID:19621348] comment: Cell surface markers are associated with human cells. subset: human_subset subset: mouse_subset is_a: CL:0000547 {is_inferred="true"} ! proerythroblast intersection_of: CL:0000547 ! proerythroblast intersection_of: CL:4030046 PR:000001003 ! lacks_plasma_membrane_part CD34 molecule intersection_of: CL:4030046 PR:000001460 ! lacks_plasma_membrane_part glycophorin-A relationship: CL:4030046 PR:000001003 ! lacks_plasma_membrane_part CD34 molecule relationship: CL:4030046 PR:000001460 ! lacks_plasma_membrane_part glycophorin-A relationship: RO:0002202 CL:0002003 ! develops from CD34-positive, GlyA-negative erythroid progenitor cell property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-04-26T10:31:50Z [Term] id: CL:0002005 name: CD34-positive, CD38-positive megakaryocyte erythroid progenitor cell def: "A megakaryocyte erythroid progenitor cell is CD34-positive, CD38-positive and is IL3-receptor alpha-negative and CD45RA-negative." [GOC:tfm, PMID:12615892, PMID:190227700] comment: Markers are associated with human cell type. subset: human_subset subset: mouse_subset is_a: CL:0000050 {is_inferred="true"} ! megakaryocyte-erythroid progenitor cell intersection_of: CL:0000050 ! megakaryocyte-erythroid progenitor cell intersection_of: CL:4030046 PR:000001015 ! lacks_plasma_membrane_part receptor-type tyrosine-protein phosphatase C isoform CD45RA intersection_of: CL:4030046 PR:000001865 ! lacks_plasma_membrane_part interleukin-3 receptor class 2 alpha chain intersection_of: RO:0002104 PR:000001003 ! has plasma membrane part CD34 molecule intersection_of: RO:0002104 PR:000001408 ! has plasma membrane part ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 relationship: CL:4030046 PR:000001015 ! lacks_plasma_membrane_part receptor-type tyrosine-protein phosphatase C isoform CD45RA relationship: CL:4030046 PR:000001865 ! lacks_plasma_membrane_part interleukin-3 receptor class 2 alpha chain relationship: RO:0002104 PR:000001003 ! has plasma membrane part CD34 molecule relationship: RO:0002104 PR:000001408 ! has plasma membrane part ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-01-13T03:43:10Z [Term] id: CL:0002006 name: Kit-positive, CD34-negative megakaryocyte erythroid progenitor cell def: "A megakaryocyte erythroid progenitor cell that is Kit-positive and is Sca1-negative, CD34-negative, CD90-negative, IL7r-alpha-negative and Fcgr II/III-low." [GOC:tfm, http://www.immgen.org/index_content.html, PMID:12615892, PMID:19022770] comment: Markers are associated with mouse cells. subset: human_subset subset: mouse_subset is_a: CL:0000050 {is_inferred="true"} ! megakaryocyte-erythroid progenitor cell intersection_of: CL:0000050 ! megakaryocyte-erythroid progenitor cell intersection_of: CL:4030046 PR:000001003 ! lacks_plasma_membrane_part CD34 molecule intersection_of: CL:4030046 PR:000001479 ! lacks_plasma_membrane_part low affinity immunoglobulin gamma Fc region receptor II intersection_of: CL:4030046 PR:000001843 ! lacks_plasma_membrane_part Thy-1 membrane glycoprotein intersection_of: CL:4030046 PR:000001869 ! lacks_plasma_membrane_part interleukin-7 receptor subunit alpha intersection_of: CL:4030046 PR:000002979 ! lacks_plasma_membrane_part lymphocyte antigen 6A-2/6E-1 intersection_of: RO:0002104 PR:000002065 ! has plasma membrane part mast/stem cell growth factor receptor intersection_of: RO:0015016 GO:0033001 ! has low plasma membrane amount Fc-gamma receptor III complex relationship: CL:4030046 PR:000001003 ! lacks_plasma_membrane_part CD34 molecule relationship: CL:4030046 PR:000001479 ! lacks_plasma_membrane_part low affinity immunoglobulin gamma Fc region receptor II relationship: CL:4030046 PR:000001843 ! lacks_plasma_membrane_part Thy-1 membrane glycoprotein relationship: CL:4030046 PR:000001869 ! lacks_plasma_membrane_part interleukin-7 receptor subunit alpha relationship: CL:4030046 PR:000002979 ! lacks_plasma_membrane_part lymphocyte antigen 6A-2/6E-1 relationship: RO:0002104 PR:000002065 ! has plasma membrane part mast/stem cell growth factor receptor relationship: RO:0015016 GO:0033001 ! has low plasma membrane amount Fc-gamma receptor III complex property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-01-13T03:43:12Z [Term] id: CL:0002007 name: Kit-low, CD34-positive eosinophil progenitor cell def: "A lineage marker-negative, CD34-positive, IL5r-alpha-positive, and Sca1-negative eosinophil progenitor cell." [GOC:tfm, PMID:17582345] comment: Markers are found on mouse cells. subset: human_subset subset: mouse_subset is_a: CL:0000611 {is_inferred="true"} ! eosinophil progenitor cell intersection_of: CL:0000611 ! eosinophil progenitor cell intersection_of: CL:4030046 PR:000002979 ! lacks_plasma_membrane_part lymphocyte antigen 6A-2/6E-1 intersection_of: RO:0002104 PR:000001003 ! has plasma membrane part CD34 molecule intersection_of: RO:0002104 PR:000001867 ! has plasma membrane part interleukin-5 receptor subunit alpha intersection_of: RO:0015016 PR:000002065 ! has low plasma membrane amount mast/stem cell growth factor receptor relationship: CL:4030046 PR:000002979 ! lacks_plasma_membrane_part lymphocyte antigen 6A-2/6E-1 relationship: RO:0002202 CL:0002002 ! develops from Kit-positive granulocyte monocyte progenitor relationship: RO:0015016 PR:000002065 ! has low plasma membrane amount mast/stem cell growth factor receptor property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-01-14T03:25:15Z [Term] id: CL:0002008 name: CD34-positive, CD38-positive eosinophil progenitor cell def: "A lineage marker-negative, CD34-positive, CD38-positive, IL3r-alpha-positive, IL5r-alpha-positive, and CD45RA-negative eosinophil progenitor cell." [GOC:tfm, PMCID:PMC2626675] comment: Markers are associated with human cells. subset: human_subset subset: mouse_subset is_a: CL:0000611 {is_inferred="true"} ! eosinophil progenitor cell intersection_of: CL:0000611 ! eosinophil progenitor cell intersection_of: RO:0002104 PR:000001015 ! has plasma membrane part receptor-type tyrosine-protein phosphatase C isoform CD45RA intersection_of: RO:0002104 PR:000001408 ! has plasma membrane part ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 intersection_of: RO:0002104 PR:000001865 ! has plasma membrane part interleukin-3 receptor class 2 alpha chain relationship: RO:0002104 PR:000001015 ! has plasma membrane part receptor-type tyrosine-protein phosphatase C isoform CD45RA relationship: RO:0002202 CL:0002001 ! develops from CD34-positive, CD38-positive granulocyte monocyte progenitor property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-01-14T03:25:17Z [Term] id: CL:0002009 name: macrophage dendritic cell progenitor def: "A progenitor cell that can give rise to plasmacytoid and myeloid dendritic cells, and to monocytes and macrophages." [GOC:tfm, PMID:19273628] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "MDP" EXACT [] is_a: CL:0000763 ! myeloid cell is_a: CL:0002032 {is_inferred="true"} ! hematopoietic oligopotent progenitor cell is_a: CL:0011026 ! progenitor cell intersection_of: CL:0002032 ! hematopoietic oligopotent progenitor cell intersection_of: RO:0002215 GO:0030224 ! capable of monocyte differentiation intersection_of: RO:0002215 GO:0043011 ! capable of myeloid dendritic cell differentiation relationship: RO:0002202 CL:0000557 ! develops from granulocyte monocyte progenitor cell relationship: RO:0002215 GO:0030224 ! capable of monocyte differentiation relationship: RO:0002215 GO:0043011 ! capable of myeloid dendritic cell differentiation property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-01-19T02:51:58Z [Term] id: CL:0002010 name: pre-conventional dendritic cell def: "A lin-negative, MHC-II-negative, CD11c-positive, FLT3-positive cell with intermediate expression of SIRP-alpha." [GOC:tfm] subset: cellxgene_subset subset: human_subset subset: mouse_subset is_a: CL:0000763 ! myeloid cell is_a: CL:0002031 {is_inferred="true"} ! hematopoietic lineage restricted progenitor cell intersection_of: CL:0002031 ! hematopoietic lineage restricted progenitor cell intersection_of: CL:4030046 GO:0042613 ! lacks_plasma_membrane_part MHC class II protein complex intersection_of: CL:4030046 PR:000001002 ! lacks_plasma_membrane_part CD19 molecule intersection_of: CL:4030046 PR:000001004 ! lacks_plasma_membrane_part CD4 molecule intersection_of: CL:4030046 PR:000001012 ! lacks_plasma_membrane_part integrin alpha-M intersection_of: CL:4030046 PR:000001020 ! lacks_plasma_membrane_part CD3 epsilon intersection_of: CL:4030046 PR:000001024 ! lacks_plasma_membrane_part neural cell adhesion molecule 1 intersection_of: CL:4030046 PR:000001083 ! lacks_plasma_membrane_part CD2 molecule intersection_of: CL:4030046 PR:000001084 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD8 alpha chain intersection_of: CL:4030046 PR:000001289 ! lacks_plasma_membrane_part membrane-spanning 4-domains subfamily A member 1 intersection_of: CL:4030046 PR:000001839 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD5 intersection_of: CL:4030046 PR:000001889 ! lacks_plasma_membrane_part CD14 molecule intersection_of: CL:4030046 PR:000002978 ! lacks_plasma_membrane_part lymphocyte antigen 6G intersection_of: CL:4030046 PR:000002981 ! lacks_plasma_membrane_part lymphocyte antigen 76 (mouse) intersection_of: RO:0002104 PR:000001013 ! has plasma membrane part integrin alpha-X intersection_of: RO:0002104 PR:000001968 ! has plasma membrane part tyrosine-protein phosphatase non-receptor type substrate 1 intersection_of: RO:0002104 PR:000002001 ! has plasma membrane part receptor-type tyrosine-protein kinase FLT3 relationship: CL:4030046 GO:0042613 ! lacks_plasma_membrane_part MHC class II protein complex relationship: CL:4030046 PR:000001002 ! lacks_plasma_membrane_part CD19 molecule relationship: CL:4030046 PR:000001004 ! lacks_plasma_membrane_part CD4 molecule relationship: CL:4030046 PR:000001012 ! lacks_plasma_membrane_part integrin alpha-M relationship: CL:4030046 PR:000001020 ! lacks_plasma_membrane_part CD3 epsilon relationship: CL:4030046 PR:000001024 ! lacks_plasma_membrane_part neural cell adhesion molecule 1 relationship: CL:4030046 PR:000001083 ! lacks_plasma_membrane_part CD2 molecule relationship: CL:4030046 PR:000001084 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD8 alpha chain relationship: CL:4030046 PR:000001289 ! lacks_plasma_membrane_part membrane-spanning 4-domains subfamily A member 1 relationship: CL:4030046 PR:000001839 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD5 relationship: CL:4030046 PR:000001889 ! lacks_plasma_membrane_part CD14 molecule relationship: CL:4030046 PR:000002978 ! lacks_plasma_membrane_part lymphocyte antigen 6G relationship: CL:4030046 PR:000002981 ! lacks_plasma_membrane_part lymphocyte antigen 76 (mouse) relationship: RO:0002104 PR:000001013 ! has plasma membrane part integrin alpha-X relationship: RO:0002104 PR:000001968 ! has plasma membrane part tyrosine-protein phosphatase non-receptor type substrate 1 relationship: RO:0002104 PR:000002001 ! has plasma membrane part receptor-type tyrosine-protein kinase FLT3 relationship: RO:0002202 CL:0001029 ! develops from common dendritic progenitor property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0002010" xsd:string {name="pre-conventional dendritic cell on CELLxGENE CellGuide"} property_value: terms:description "The pre-conventional dendritic cell (pre-cDC) are precursors of mature dendritic cells. They develop from common DC precursors in the bone marrow and exist in a semi-differentiated state. The term 'pre-conventional' denotes the stage of development of these cells prior to their maturation into conventional dendritic cells, which are critical players in immune responses. \nAfter leaving the bone marrow, pre-cDCs transiently circulate in the bloodstream to colonize lymphoid and non-lymphoid tissues, including skin, mucosa, spleen, and lymph nodes where they differentiate into immature conventional dendritic cells, which undergo further differentiation. In mouse and humans, the population of pre-cDCs has been shown to be heterogeneous with two subpopulations that pre-committed to differentiate into different subsets of dendritic cells (cDC1 and cDC2). \nThese subsets of differentiated dendritic cells play a key role in the immune response by bringing about the regulation and initiation of T cell responses, thereby shaping the adaptive immunity. One subset is thought to be specialized in highly efficient activation of CD8+ T cells, while the other subset presents exogeneous antigens to CD4+ T cells. \nThe main function of pre-conventional dendritic cells is to constantly replenish conventional dendritic cells. In response to infection additional pre-cDCs are recruited to the site of infection to meet increased tissue demand, and this pre-DC recruitment may be necessary for effective T cell responses. The molecular signals that direct pre-cDC migration remain poorly understood but recent research suggest that it involves specific chemokine receptors expressed on pre-cDCs.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1002/embj.201488027", xref="DOI:10.1084/jem.20161135", xref="DOI:10.1111/imm.12888", xref="DOI:10.1146/annurev-immunol-061020-053707", xref="DOI:\\10.1038/s41423-021-00726-4"} creation_date: 2010-01-19T03:39:30Z [Term] id: CL:0002011 name: Kit-positive macrophage dendritic cell progenitor def: "A progenitor cell that can give rise to plasmacytoid and myeloid dendritic cells, and to monocytes and macrophages. Marker for this cell is Kit-high, CD115-positive, CD135-positive, Cx3cr1-positive, and is Il7ra-negative." [GOC:tfm, PMID:19273628] comment: Markers are associated with mouse cells. subset: human_subset subset: mouse_subset synonym: "murine MDP" EXACT [] is_a: CL:0002009 {is_inferred="true"} ! macrophage dendritic cell progenitor intersection_of: CL:0002009 ! macrophage dendritic cell progenitor intersection_of: RO:0002104 PR:000001206 ! has plasma membrane part CX3C chemokine receptor 1 intersection_of: RO:0002104 PR:000002001 ! has plasma membrane part receptor-type tyrosine-protein kinase FLT3 intersection_of: RO:0002104 PR:000002062 ! has plasma membrane part macrophage colony-stimulating factor 1 receptor intersection_of: RO:0015015 PR:000002065 ! has high plasma membrane amount mast/stem cell growth factor receptor relationship: RO:0002104 PR:000001206 ! has plasma membrane part CX3C chemokine receptor 1 relationship: RO:0002104 PR:000002001 ! has plasma membrane part receptor-type tyrosine-protein kinase FLT3 relationship: RO:0002104 PR:000002062 ! has plasma membrane part macrophage colony-stimulating factor 1 receptor relationship: RO:0002202 CL:0002002 ! develops from Kit-positive granulocyte monocyte progenitor relationship: RO:0015015 PR:000002065 ! has high plasma membrane amount mast/stem cell growth factor receptor property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-01-26T02:43:40Z [Term] id: CL:0002012 name: Kit-low proerythroblast def: "A proerythoblast that is Kit-low, Lyg76-positive, and CD71-positive." [GOC:ak, GOC:tfm, PMID:19805084] comment: Markers are associated with mouse cells. subset: mouse_subset is_a: CL:0000547 {is_inferred="true"} ! proerythroblast intersection_of: CL:0000547 ! proerythroblast intersection_of: CL:4030046 PR:000001869 ! lacks_plasma_membrane_part interleukin-7 receptor subunit alpha intersection_of: CL:4030046 PR:000002979 ! lacks_plasma_membrane_part lymphocyte antigen 6A-2/6E-1 intersection_of: RO:0002104 PR:000002981 ! has plasma membrane part lymphocyte antigen 76 (mouse) intersection_of: RO:0015015 PR:000001945 ! has high plasma membrane amount transferrin receptor protein 1 intersection_of: RO:0015016 PR:000002065 ! has low plasma membrane amount mast/stem cell growth factor receptor relationship: CL:4030046 PR:000001869 ! lacks_plasma_membrane_part interleukin-7 receptor subunit alpha relationship: CL:4030046 PR:000002979 ! lacks_plasma_membrane_part lymphocyte antigen 6A-2/6E-1 relationship: RO:0002104 PR:000002981 ! has plasma membrane part lymphocyte antigen 76 (mouse) relationship: RO:0002202 CL:0002000 ! develops from Kit-positive erythroid progenitor cell relationship: RO:0015015 PR:000001945 ! has high plasma membrane amount transferrin receptor protein 1 relationship: RO:0015016 PR:000002065 ! has low plasma membrane amount mast/stem cell growth factor receptor property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-04-26T10:31:56Z [Term] id: CL:0002013 name: GlyA-positive basophilic erythroblast def: "A basophilic erythroblast that is GlyA-positive." [GOC:ak, GOC:tfm, PMID:1638021] comment: Markers are associated with human cells. subset: human_subset subset: mouse_subset is_a: CL:0000549 {is_inferred="true"} ! basophilic erythroblast intersection_of: CL:0000549 ! basophilic erythroblast intersection_of: CL:4030046 PR:000001003 ! lacks_plasma_membrane_part CD34 molecule intersection_of: RO:0002104 PR:000001460 ! has plasma membrane part glycophorin-A relationship: CL:4030046 PR:000001003 ! lacks_plasma_membrane_part CD34 molecule relationship: RO:0002104 PR:000001460 ! has plasma membrane part glycophorin-A relationship: RO:0002202 CL:0002004 ! develops from CD34-negative, GlyA-negative proerythroblast property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-04-26T10:41:15Z [Term] id: CL:0002014 name: Kit-negative, Ly-76 high basophilic erythroblast def: "A basophilic erythroblast that is Lyg 76-high and is Kit-negative." [GOC:ak, GOC:tfm, PMID:19805084] comment: Cell surface markers are associated with mouse cells. subset: mouse_subset is_a: CL:0000549 {is_inferred="true"} ! basophilic erythroblast intersection_of: CL:0000549 ! basophilic erythroblast intersection_of: CL:4030046 PR:000001869 ! lacks_plasma_membrane_part interleukin-7 receptor subunit alpha intersection_of: CL:4030046 PR:000002065 ! lacks_plasma_membrane_part mast/stem cell growth factor receptor intersection_of: CL:4030046 PR:000002979 ! lacks_plasma_membrane_part lymphocyte antigen 6A-2/6E-1 intersection_of: RO:0015015 PR:000002981 ! has high plasma membrane amount lymphocyte antigen 76 (mouse) relationship: CL:4030046 PR:000001869 ! lacks_plasma_membrane_part interleukin-7 receptor subunit alpha relationship: CL:4030046 PR:000002065 ! lacks_plasma_membrane_part mast/stem cell growth factor receptor relationship: CL:4030046 PR:000002979 ! lacks_plasma_membrane_part lymphocyte antigen 6A-2/6E-1 relationship: RO:0002202 CL:0002012 ! develops from Kit-low proerythroblast relationship: RO:0015015 PR:000002981 ! has high plasma membrane amount lymphocyte antigen 76 (mouse) property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-04-26T10:41:22Z [Term] id: CL:0002015 name: Kit-negative, Ly-76 high polychromatophilic erythroblast def: "A polychromatophilic erythroblast that is Lyg 76-high and is Kit-negative." [GOC:ak, GOC:tfm, PMID:19805084] subset: mouse_subset synonym: "late basophilic and polychromatophilic erythroblast" BROAD [] is_a: CL:0000550 {is_inferred="true"} ! polychromatophilic erythroblast intersection_of: CL:0000550 ! polychromatophilic erythroblast intersection_of: CL:4030046 PR:000001869 ! lacks_plasma_membrane_part interleukin-7 receptor subunit alpha intersection_of: CL:4030046 PR:000002065 ! lacks_plasma_membrane_part mast/stem cell growth factor receptor intersection_of: CL:4030046 PR:000002979 ! lacks_plasma_membrane_part lymphocyte antigen 6A-2/6E-1 intersection_of: RO:0015015 PR:000002981 ! has high plasma membrane amount lymphocyte antigen 76 (mouse) relationship: CL:4030046 PR:000001869 ! lacks_plasma_membrane_part interleukin-7 receptor subunit alpha relationship: CL:4030046 PR:000002065 ! lacks_plasma_membrane_part mast/stem cell growth factor receptor relationship: CL:4030046 PR:000002979 ! lacks_plasma_membrane_part lymphocyte antigen 6A-2/6E-1 relationship: RO:0002202 CL:0002014 ! develops from Kit-negative, Ly-76 high basophilic erythroblast relationship: RO:0015015 PR:000002981 ! has high plasma membrane amount lymphocyte antigen 76 (mouse) property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-04-26T10:53:11Z [Term] id: CL:0002016 name: CD71-low, GlyA-positive polychromatic erythroblast def: "A polychromatiic erythroblast that is Gly-A-positive and CD71-low." [GOC:ak, GOC:tfm, PMID:1638021] comment: Cell surface markers are associated with human cells. subset: human_subset subset: mouse_subset is_a: CL:0000550 {is_inferred="true"} ! polychromatophilic erythroblast intersection_of: CL:0000550 ! polychromatophilic erythroblast intersection_of: RO:0002104 PR:000001460 ! has plasma membrane part glycophorin-A intersection_of: RO:0015016 PR:000001945 ! has low plasma membrane amount transferrin receptor protein 1 relationship: RO:0002104 PR:000001460 ! has plasma membrane part glycophorin-A relationship: RO:0002202 CL:0002013 ! develops from GlyA-positive basophilic erythroblast relationship: RO:0015016 PR:000001945 ! has low plasma membrane amount transferrin receptor protein 1 property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-04-26T10:53:16Z [Term] id: CL:0002017 name: Kit-negative, Ly-76 high orthochromatophilic erythroblasts def: "An orthochromatophilic erythroblast that is ter119-high, CD71-low, and Kit-negative." [GOC:ak, GOC:tfm, PMID:19805084] comment: Cell surface markers associated with mouse cells. subset: mouse_subset is_a: CL:0000552 {is_inferred="true"} ! orthochromatic erythroblast intersection_of: CL:0000552 ! orthochromatic erythroblast intersection_of: CL:4030046 PR:000001869 ! lacks_plasma_membrane_part interleukin-7 receptor subunit alpha intersection_of: CL:4030046 PR:000002065 ! lacks_plasma_membrane_part mast/stem cell growth factor receptor intersection_of: CL:4030046 PR:000002979 ! lacks_plasma_membrane_part lymphocyte antigen 6A-2/6E-1 intersection_of: RO:0015015 PR:000002981 ! has high plasma membrane amount lymphocyte antigen 76 (mouse) intersection_of: RO:0015016 PR:000001945 ! has low plasma membrane amount transferrin receptor protein 1 relationship: CL:4030046 PR:000001869 ! lacks_plasma_membrane_part interleukin-7 receptor subunit alpha relationship: CL:4030046 PR:000002065 ! lacks_plasma_membrane_part mast/stem cell growth factor receptor relationship: CL:4030046 PR:000002979 ! lacks_plasma_membrane_part lymphocyte antigen 6A-2/6E-1 relationship: RO:0002202 CL:0002015 ! develops from Kit-negative, Ly-76 high polychromatophilic erythroblast relationship: RO:0015015 PR:000002981 ! has high plasma membrane amount lymphocyte antigen 76 (mouse) relationship: RO:0015016 PR:000001945 ! has low plasma membrane amount transferrin receptor protein 1 property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-04-26T11:04:15Z [Term] id: CL:0002018 name: CD71-negative, GlyA-positive orthochromatic erythroblast def: "An erythroblast that is GlyA-positive and CD71-negative." [GOC:ak, GOC:tfm, PMID:1638021] comment: Markers associated with human cells. subset: human_subset subset: mouse_subset is_a: CL:0000552 {is_inferred="true"} ! orthochromatic erythroblast intersection_of: CL:0000552 ! orthochromatic erythroblast intersection_of: CL:4030046 PR:000001945 ! lacks_plasma_membrane_part transferrin receptor protein 1 intersection_of: RO:0002104 PR:000001460 ! has plasma membrane part glycophorin-A relationship: CL:4030046 PR:000001945 ! lacks_plasma_membrane_part transferrin receptor protein 1 relationship: RO:0002104 PR:000001460 ! has plasma membrane part glycophorin-A relationship: RO:0002202 CL:0002016 ! develops from CD71-low, GlyA-positive polychromatic erythroblast property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-04-26T11:04:21Z [Term] id: CL:0002019 name: Ly-76 high reticulocyte def: "A reticulocyte that is Ly76-high and is Kit-negative." [GOC:ak, GOC:tfm, PMID:18539294] comment: Marker associated with mouse cells. subset: mouse_subset is_a: CL:0002422 {is_inferred="true"} ! enucleated reticulocyte intersection_of: CL:0002422 ! enucleated reticulocyte intersection_of: RO:0015015 PR:000002981 ! has high plasma membrane amount lymphocyte antigen 76 (mouse) relationship: RO:0002202 CL:0002017 ! develops from Kit-negative, Ly-76 high orthochromatophilic erythroblasts relationship: RO:0015015 PR:000002981 ! has high plasma membrane amount lymphocyte antigen 76 (mouse) property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-04-26T11:37:00Z [Term] id: CL:0002020 name: GlyA-positive reticulocytes def: "A reticulocyte that is GlyA-positive." [GOC:ak, GOC:tfm, PMID:1638021] comment: Markers is associated with human cells. subset: human_subset subset: mouse_subset is_a: CL:0002422 {is_inferred="true"} ! enucleated reticulocyte intersection_of: CL:0002422 ! enucleated reticulocyte intersection_of: RO:0002104 PR:000001460 ! has plasma membrane part glycophorin-A relationship: RO:0002104 PR:000001460 ! has plasma membrane part glycophorin-A relationship: RO:0002202 CL:0002018 ! develops from CD71-negative, GlyA-positive orthochromatic erythroblast property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-04-26T11:48:25Z [Term] id: CL:0002021 name: GlyA-positive erythrocyte def: "An enucleate erythrocyte that is GlyA-positive." [GOC:ak, GOC:tfm, PMID:20134094] comment: Marker is associated with human cell types. subset: human_subset subset: mouse_subset is_a: CL:0000595 {is_inferred="true"} ! enucleate erythrocyte intersection_of: CL:0000595 ! enucleate erythrocyte intersection_of: RO:0002104 PR:000001460 ! has plasma membrane part glycophorin-A relationship: RO:0002104 PR:000001460 ! has plasma membrane part glycophorin-A relationship: RO:0002202 CL:0002020 ! develops from GlyA-positive reticulocytes property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-04-26T11:51:22Z [Term] id: CL:0002022 name: Ly-76 high positive erythrocyte def: "An enucleate erythrocyte that is Lyg-76-high." [GOC:ak, GOC:tfm, PMID:19805084] comment: Marker is associated with mouse cell types. subset: mouse_subset is_a: CL:0000595 {is_inferred="true"} ! enucleate erythrocyte intersection_of: CL:0000595 ! enucleate erythrocyte intersection_of: RO:0015015 PR:000002981 ! has high plasma membrane amount lymphocyte antigen 76 (mouse) relationship: RO:0002202 CL:0002019 ! develops from Ly-76 high reticulocyte relationship: RO:0015015 PR:000002981 ! has high plasma membrane amount lymphocyte antigen 76 (mouse) property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-04-26T11:51:27Z [Term] id: CL:0002023 name: CD34-positive, CD41-positive, CD42-positive megakaryocyte progenitor cell def: "A megakaroycotye progenitor cell that is CD34-positive, CD41-positive and CD42-positive on the cell surface." [GOC:ak, GOC:tfm, PMID:15232614] comment: Markers are associated with human cell type. subset: human_subset subset: mouse_subset is_a: CL:0000553 {is_inferred="true"} ! megakaryocyte progenitor cell intersection_of: CL:0000553 ! megakaryocyte progenitor cell intersection_of: RO:0002104 PR:000001003 ! has plasma membrane part CD34 molecule intersection_of: RO:0002104 PR:000001907 ! has plasma membrane part platelet glycoprotein Ib alpha chain intersection_of: RO:0002104 PR:000009127 ! has plasma membrane part integrin alpha-IIb relationship: RO:0002104 PR:000001003 ! has plasma membrane part CD34 molecule relationship: RO:0002104 PR:000001907 ! has plasma membrane part platelet glycoprotein Ib alpha chain relationship: RO:0002104 PR:000009127 ! has plasma membrane part integrin alpha-IIb relationship: RO:0002202 CL:0002025 ! develops from CD34-positive, CD41-positive, CD42-negative megakaryocyte progenitor cell property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-04-26T02:39:09Z [Term] id: CL:0002024 name: Kit-positive megakaryocyte progenitor cell def: "A megakaryocyte progenitor cell that is Kit-positive, CD41-positive, CD9-positive, Sca-1-negative, IL7ralpha-negative, CD150-negative, and Fcgamma receptor II/III-low." [GOC:ak, GOC:tfm, PMID:16951553] comment: Markers are associated with mouse cells. subset: human_subset subset: mouse_subset is_a: CL:0000553 {is_inferred="true"} ! megakaryocyte progenitor cell intersection_of: CL:0000553 ! megakaryocyte progenitor cell intersection_of: CL:4030046 PR:000001833 ! lacks_plasma_membrane_part SLAM family member 1 intersection_of: CL:4030046 PR:000001869 ! lacks_plasma_membrane_part interleukin-7 receptor subunit alpha intersection_of: CL:4030046 PR:000002979 ! lacks_plasma_membrane_part lymphocyte antigen 6A-2/6E-1 intersection_of: RO:0002104 PR:000002065 ! has plasma membrane part mast/stem cell growth factor receptor intersection_of: RO:0002104 PR:000005178 ! has plasma membrane part CD9 molecule intersection_of: RO:0015016 PR:000001479 ! has low plasma membrane amount low affinity immunoglobulin gamma Fc region receptor II intersection_of: RO:0015016 PR:000001483 ! has low plasma membrane amount low affinity immunoglobulin gamma Fc region receptor III relationship: CL:4030046 PR:000001833 ! lacks_plasma_membrane_part SLAM family member 1 relationship: CL:4030046 PR:000001869 ! lacks_plasma_membrane_part interleukin-7 receptor subunit alpha relationship: CL:4030046 PR:000002979 ! lacks_plasma_membrane_part lymphocyte antigen 6A-2/6E-1 relationship: RO:0002104 PR:000002065 ! has plasma membrane part mast/stem cell growth factor receptor relationship: RO:0002104 PR:000005178 ! has plasma membrane part CD9 molecule relationship: RO:0002202 CL:0002006 ! develops from Kit-positive, CD34-negative megakaryocyte erythroid progenitor cell relationship: RO:0015016 PR:000001479 ! has low plasma membrane amount low affinity immunoglobulin gamma Fc region receptor II relationship: RO:0015016 PR:000001483 ! has low plasma membrane amount low affinity immunoglobulin gamma Fc region receptor III property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-04-26T02:39:15Z [Term] id: CL:0002025 name: CD34-positive, CD41-positive, CD42-negative megakaryocyte progenitor cell def: "A megakaryocyte progenitor cell that is CD34-positive, CD41-positive, and CD42-negative." [GOC:ak, GOC:tfm, PMID:15232614] comment: Markers are commonly associated with human cells. subset: human_subset subset: mouse_subset is_a: CL:0000553 {is_inferred="true"} ! megakaryocyte progenitor cell intersection_of: CL:0000553 ! megakaryocyte progenitor cell intersection_of: CL:4030046 PR:000001907 ! lacks_plasma_membrane_part platelet glycoprotein Ib alpha chain intersection_of: RO:0002104 PR:000001003 ! has plasma membrane part CD34 molecule intersection_of: RO:0002104 PR:000009127 ! has plasma membrane part integrin alpha-IIb relationship: CL:4030046 PR:000001907 ! lacks_plasma_membrane_part platelet glycoprotein Ib alpha chain relationship: RO:0002104 PR:000001003 ! has plasma membrane part CD34 molecule relationship: RO:0002104 PR:000009127 ! has plasma membrane part integrin alpha-IIb relationship: RO:0002202 CL:0002005 ! develops from CD34-positive, CD38-positive megakaryocyte erythroid progenitor cell property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-04-26T03:52:47Z [Term] id: CL:0002026 name: CD34-negative, CD41-positive, CD42-positive megakaryocyte cell def: "A megakaryocyte progenitor cell that is CD34-negative, CD41-positive and CD42-positive." [GOC:ak, GOC:tfm, PMID:15232614] comment: Markers are commonly associated with human cells. subset: human_subset subset: mouse_subset is_a: CL:0000556 {is_inferred="true"} ! megakaryocyte intersection_of: CL:0000556 ! megakaryocyte intersection_of: CL:4030046 PR:000001003 ! lacks_plasma_membrane_part CD34 molecule intersection_of: RO:0002104 PR:000001907 ! has plasma membrane part platelet glycoprotein Ib alpha chain intersection_of: RO:0002104 PR:000009127 ! has plasma membrane part integrin alpha-IIb relationship: CL:4030046 PR:000001003 ! lacks_plasma_membrane_part CD34 molecule relationship: RO:0002104 PR:000001907 ! has plasma membrane part platelet glycoprotein Ib alpha chain relationship: RO:0002104 PR:000009127 ! has plasma membrane part integrin alpha-IIb relationship: RO:0002202 CL:0002023 ! develops from CD34-positive, CD41-positive, CD42-positive megakaryocyte progenitor cell property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-04-26T03:59:22Z [Term] id: CL:0002027 name: CD9-positive, CD41-positive megakaryocyte cell def: "A megakaryocyte cell with is CD9-positive and CD41-positive." [GOC:tfm] comment: Markers are commonly associated with mouse cells. subset: human_subset subset: mouse_subset is_a: CL:0000556 {is_inferred="true"} ! megakaryocyte intersection_of: CL:0000556 ! megakaryocyte intersection_of: RO:0002104 PR:000005178 ! has plasma membrane part CD9 molecule intersection_of: RO:0002104 PR:000009127 ! has plasma membrane part integrin alpha-IIb relationship: RO:0002104 PR:000005178 ! has plasma membrane part CD9 molecule relationship: RO:0002104 PR:000009127 ! has plasma membrane part integrin alpha-IIb relationship: RO:0002202 CL:0002024 ! develops from Kit-positive megakaryocyte progenitor cell property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-04-27T10:39:07Z [Term] id: CL:0002028 name: basophil mast progenitor cell def: "A cell type that can give rise to basophil and mast cells. This cell is CD34-positive, CD117-positive, CD125-positive, FceRIa-negative, and T1/ST2-negative, and expresses Gata-1, Gata-2, C/EBPa" [GOC:ak, GOC:dsd, GOC:tfm, PMCID:PMC1312421] comment: There may be an intermediate cell type. These cells also CD13-positive, CD16-positive, CD32-positive, and integrin beta 7-positive. Transcription factors: GATA1-positive, MCP-1-positive, mitf-positive, PU.1-positive, and CEBP/a-low. subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "BMCP" EXACT [] is_a: CL:0000763 ! myeloid cell is_a: CL:0002191 ! granulocytopoietic cell intersection_of: CL:0000839 ! myeloid lineage restricted progenitor cell intersection_of: BFO:0000051 PR:000005307 ! has part CCAAT/enhancer-binding protein alpha intersection_of: BFO:0000051 PR:000007857 ! has part erythroid transcription factor intersection_of: BFO:0000051 PR:000007858 ! has part endothelial transcription factor GATA-2 intersection_of: CL:4030046 PR:000007431 ! lacks_plasma_membrane_part high affinity immunoglobulin epsilon receptor subunit alpha intersection_of: CL:4030046 PR:000016401 ! lacks_plasma_membrane_part transmembrane emp24 domain-containing protein 1 intersection_of: RO:0002104 PR:000001867 ! has plasma membrane part interleukin-5 receptor subunit alpha intersection_of: RO:0002215 GO:0030221 ! capable of basophil differentiation intersection_of: RO:0002215 GO:0060374 ! capable of mast cell differentiation relationship: BFO:0000051 PR:000005307 ! has part CCAAT/enhancer-binding protein alpha relationship: BFO:0000051 PR:000007857 ! has part erythroid transcription factor relationship: BFO:0000051 PR:000007858 ! has part endothelial transcription factor GATA-2 relationship: CL:4030046 PR:000007431 ! lacks_plasma_membrane_part high affinity immunoglobulin epsilon receptor subunit alpha relationship: CL:4030046 PR:000016401 ! lacks_plasma_membrane_part transmembrane emp24 domain-containing protein 1 relationship: RO:0002104 PR:000001867 ! has plasma membrane part interleukin-5 receptor subunit alpha relationship: RO:0002202 CL:0000557 ! develops from granulocyte monocyte progenitor cell relationship: RO:0002215 GO:0030221 ! capable of basophil differentiation relationship: RO:0002215 GO:0060374 ! capable of mast cell differentiation property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-04-27T12:46:33Z [Term] id: CL:0002029 name: Fc-epsilon RIalpha-low mast cell progenitor def: "A lineage-negative, Kit-positive, CD45-positive mast cell progenitor that is Fc-epsilon RIalpha-low." [GOC:tfm, PMCID:PMC1312421] subset: human_subset subset: mouse_subset is_a: CL:0000831 {is_inferred="true"} ! mast cell progenitor intersection_of: CL:0000831 ! mast cell progenitor intersection_of: CL:4030046 PR:000002979 ! lacks_plasma_membrane_part lymphocyte antigen 6A-2/6E-1 intersection_of: RO:0002104 PR:000001006 ! has plasma membrane part receptor-type tyrosine-protein phosphatase C intersection_of: RO:0002104 PR:000002065 ! has plasma membrane part mast/stem cell growth factor receptor intersection_of: RO:0002104 PR:000009143 ! has plasma membrane part integrin beta-7 intersection_of: RO:0015016 PR:000007431 ! has low plasma membrane amount high affinity immunoglobulin epsilon receptor subunit alpha relationship: RO:0002104 PR:000001006 ! has plasma membrane part receptor-type tyrosine-protein phosphatase C relationship: RO:0002202 CL:0002044 ! develops from Kit-positive, integrin beta7-high basophil mast progenitor cell property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-04-27T01:22:19Z [Term] id: CL:0002030 name: Fc-epsilon RIalpha-high basophil progenitor cell def: "A lineage negative, Sca1-negative basophil progenitor cell that is Fc epsilon RIalpha-high." [GOC:tfm, PMCID:PMC1312421] comment: Markers are associated with mouse cells. subset: human_subset subset: mouse_subset is_a: CL:0000613 {is_inferred="true"} ! basophil progenitor cell intersection_of: CL:0000613 ! basophil progenitor cell intersection_of: CL:4030046 PR:000002065 ! lacks_plasma_membrane_part mast/stem cell growth factor receptor intersection_of: CL:4030046 PR:000002979 ! lacks_plasma_membrane_part lymphocyte antigen 6A-2/6E-1 intersection_of: RO:0002104 PR:000001003 ! has plasma membrane part CD34 molecule intersection_of: RO:0015015 PR:000007431 ! has high plasma membrane amount high affinity immunoglobulin epsilon receptor subunit alpha relationship: CL:4030046 PR:000002979 ! lacks_plasma_membrane_part lymphocyte antigen 6A-2/6E-1 relationship: RO:0002104 PR:000001003 ! has plasma membrane part CD34 molecule relationship: RO:0002202 CL:0002044 ! develops from Kit-positive, integrin beta7-high basophil mast progenitor cell property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-04-27T01:22:32Z [Term] id: CL:0002031 name: hematopoietic lineage restricted progenitor cell def: "A hematopoietic progenitor cell that is capable of developing into only one lineage of hematopoietic cells." [GOC:tfm, PMID:19022770] subset: blood_and_immune_upper_slim subset: human_subset subset: mouse_subset is_a: BFO:0000002 is_a: CL:0000255 ! eukaryotic cell is_a: CL:0008001 ! hematopoietic precursor cell intersection_of: CL:0000988 ! hematopoietic cell intersection_of: RO:0000053 PATO:0001400 ! has characteristic unipotent disjoint_from: CL:0002032 ! hematopoietic oligopotent progenitor cell relationship: RO:0000053 PATO:0001400 ! has characteristic unipotent relationship: RO:0002202 CL:0002032 ! develops from hematopoietic oligopotent progenitor cell property_value: skos:prefLabel "hematopoietic lineage restricted progenitor cell" xsd:string property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-01-06T03:43:20Z [Term] id: CL:0002032 name: hematopoietic oligopotent progenitor cell def: "A hematopoietic oligopotent progenitor cell that has the ability to differentiate into limited cell types but lacks lineage cell markers and self renewal capabilities." [GOC:tfm, https://orcid.org/0000-0001-5208-3432, PMID:19022770] comment: This cell type is intended to be compatible with any vertebrate hematopoietic oligopotent progenitor cell. For mammalian hematopoietic oligopotent progenitor cells known to be lineage-negative, please use the term 'hematopoietic oligopotent progenitor cell' (CL_0001060). subset: blood_and_immune_upper_slim subset: cellxgene_subset subset: human_subset subset: mouse_subset is_a: BFO:0000002 is_a: CL:0000255 ! eukaryotic cell is_a: CL:0008001 ! hematopoietic precursor cell intersection_of: CL:0000988 ! hematopoietic cell intersection_of: RO:0000053 PATO:0001401 ! has characteristic oligopotent relationship: RO:0000053 PATO:0001401 ! has characteristic oligopotent relationship: RO:0002202 CL:0000837 ! develops from hematopoietic multipotent progenitor cell property_value: skos:prefLabel "hematopoietic oligopotent progenitor cell" xsd:string property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-01-06T03:43:27Z [Term] id: CL:0002033 name: short term hematopoietic stem cell def: "A hematopoietic stem cell capable of rapid replenishment of myeloerythroid progenitors and limited self renewal capability. This cell is Kit-positive, Sca1-positive, CD34-positive, CD150-positive, and is Flt3-negative." [GOC:tfm, PMID:15572596, PMID:19022770] comment: Markers are associated with mouse cells. These cells are also reportedly CD11b-low and CD90-low. subset: human_subset subset: mouse_subset synonym: "ST stem cell" EXACT [] synonym: "ST-HSC" EXACT [] is_a: CL:0001008 {is_inferred="true"} ! Kit and Sca1-positive hematopoietic stem cell intersection_of: CL:0001008 ! Kit and Sca1-positive hematopoietic stem cell intersection_of: CL:4030046 PR:000002001 ! lacks_plasma_membrane_part receptor-type tyrosine-protein kinase FLT3 intersection_of: RO:0002104 PR:000001003 ! has plasma membrane part CD34 molecule intersection_of: RO:0002104 PR:000001833 ! has plasma membrane part SLAM family member 1 relationship: CL:4030046 PR:000002001 ! lacks_plasma_membrane_part receptor-type tyrosine-protein kinase FLT3 relationship: RO:0002104 PR:000001003 ! has plasma membrane part CD34 molecule relationship: RO:0002202 CL:0002034 ! develops from long term hematopoietic stem cell property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-01-08T09:19:25Z [Term] id: CL:0002034 name: long term hematopoietic stem cell def: "A hematopoietic stem cell with long term self renewal capability. This cell is Kit-positive, Sca1-positive, CD150-positive, CD90-low, CD34-negative and Flt3-negative." [GOC:tfm, PMID:15572596, PMID:17582345] comment: Markers are associated with mouse cells. subset: human_subset subset: mouse_subset synonym: "LT stem cell" EXACT [] synonym: "LT-HSC" EXACT [] is_a: CL:0001008 {is_inferred="true"} ! Kit and Sca1-positive hematopoietic stem cell intersection_of: CL:0001008 ! Kit and Sca1-positive hematopoietic stem cell intersection_of: CL:4030046 PR:000001003 ! lacks_plasma_membrane_part CD34 molecule intersection_of: CL:4030046 PR:000002001 ! lacks_plasma_membrane_part receptor-type tyrosine-protein kinase FLT3 intersection_of: RO:0002104 PR:000001833 ! has plasma membrane part SLAM family member 1 intersection_of: RO:0015016 PR:000001843 ! has low plasma membrane amount Thy-1 membrane glycoprotein relationship: CL:4030046 PR:000001003 ! lacks_plasma_membrane_part CD34 molecule relationship: CL:4030046 PR:000002001 ! lacks_plasma_membrane_part receptor-type tyrosine-protein kinase FLT3 relationship: RO:0015016 PR:000001843 ! has low plasma membrane amount Thy-1 membrane glycoprotein property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-01-08T09:19:28Z [Term] id: CL:0002035 name: Slamf1-negative multipotent progenitor cell def: "A hematopoietic progenitor that has restricted self-renewal capability. Cell is Kit-positive, Ly6-positive, CD150-negative and Flt3-negative." [GOC:tfm, PMID:19022770] comment: Markers are associated with mouse cells. subset: human_subset subset: mouse_subset is_a: CL:0000837 {is_inferred="true"} ! hematopoietic multipotent progenitor cell intersection_of: CL:0000837 ! hematopoietic multipotent progenitor cell intersection_of: CL:4030046 PR:000001833 ! lacks_plasma_membrane_part SLAM family member 1 intersection_of: CL:4030046 PR:000002001 ! lacks_plasma_membrane_part receptor-type tyrosine-protein kinase FLT3 intersection_of: RO:0002104 PR:000002065 ! has plasma membrane part mast/stem cell growth factor receptor intersection_of: RO:0002104 PR:000002979 ! has plasma membrane part lymphocyte antigen 6A-2/6E-1 relationship: CL:4030046 PR:000001833 ! lacks_plasma_membrane_part SLAM family member 1 relationship: CL:4030046 PR:000002001 ! lacks_plasma_membrane_part receptor-type tyrosine-protein kinase FLT3 relationship: RO:0002104 PR:000002065 ! has plasma membrane part mast/stem cell growth factor receptor relationship: RO:0002104 PR:000002979 ! has plasma membrane part lymphocyte antigen 6A-2/6E-1 relationship: RO:0002202 CL:0002036 ! develops from Slamf1-positive multipotent progenitor cell property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-01-08T11:16:33Z [Term] id: CL:0002036 name: Slamf1-positive multipotent progenitor cell def: "A hematopoietic progenitor that has some limited self-renewal capability. Cells are lin-negative, Kit-positive, CD34-positive, and Slamf1-positive." [GOC:tfm, PMID:19022770] comment: Markers are associated with mouse cells. subset: human_subset subset: mouse_subset synonym: "KSL cell" EXACT [] is_a: CL:0000837 {is_inferred="true"} ! hematopoietic multipotent progenitor cell intersection_of: CL:0000837 ! hematopoietic multipotent progenitor cell intersection_of: RO:0002104 PR:000001833 ! has plasma membrane part SLAM family member 1 intersection_of: RO:0002104 PR:000002065 ! has plasma membrane part mast/stem cell growth factor receptor intersection_of: RO:0002104 PR:000002979 ! has plasma membrane part lymphocyte antigen 6A-2/6E-1 disjoint_from: CL:0002043 ! CD34-positive, CD38-negative multipotent progenitor cell relationship: RO:0002104 PR:000001833 ! has plasma membrane part SLAM family member 1 relationship: RO:0002104 PR:000002065 ! has plasma membrane part mast/stem cell growth factor receptor relationship: RO:0002104 PR:000002979 ! has plasma membrane part lymphocyte antigen 6A-2/6E-1 relationship: RO:0002202 CL:0002033 ! develops from short term hematopoietic stem cell property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-01-08T11:16:35Z [Term] id: CL:0002037 name: CD2-positive, CD5-positive, CD44-positive alpha-beta intraepithelial T cell def: "Intraepithelial T cells with a memory phenotype of CD2-positive, CD5-positive, and CD44-positive." [GOC:tfm, PMID:16048545] subset: human_subset subset: mouse_subset synonym: "memory alpha beta IEL" EXACT [PMID:16048545] is_a: CL:0000793 {is_inferred="true"} ! CD4-positive, alpha-beta intraepithelial T cell intersection_of: CL:0000793 ! CD4-positive, alpha-beta intraepithelial T cell intersection_of: RO:0002104 PR:000001083 ! has plasma membrane part CD2 molecule intersection_of: RO:0002104 PR:000001307 ! has plasma membrane part CD44 molecule intersection_of: RO:0002104 PR:000001839 ! has plasma membrane part T-cell surface glycoprotein CD5 relationship: RO:0002104 PR:000001083 ! has plasma membrane part CD2 molecule relationship: RO:0002104 PR:000001307 ! has plasma membrane part CD44 molecule relationship: RO:0002104 PR:000001839 ! has plasma membrane part T-cell surface glycoprotein CD5 property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2009-10-20T02:20:43Z [Term] id: CL:0002038 name: T follicular helper cell def: "A CD4-positive, CXCR5-positive, CCR7-negative alpha-beta T cell located in follicles of secondary lymph nodes that is BCL6-high, ICOS-high and PD1-high, and stimulates follicular B cells to undergo class-switching and antibody production." [GOC:tfm, PMID:19855402, PMID:20107805, PMID:22043829] subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "follicular B helper T cell" RELATED [PMID:22043829] synonym: "follicular helper T cell" RELATED [PMID:22649468] synonym: "follicular helper T-cell" RELATED [PMID:22508770] synonym: "follicular T cell" RELATED [PMID:20107805, PMID:21914188] synonym: "follicular T-cell" RELATED [] synonym: "follicular T-helper cell" RELATED [PMID:22552227] synonym: "T(FH)" EXACT [PMID:20207847] synonym: "Tfh" EXACT [PMID:20107805, PMID:20383172] is_a: CL:0000492 {is_inferred="true"} ! CD4-positive helper T cell intersection_of: CL:0000492 ! CD4-positive helper T cell intersection_of: BFO:0000051 PR:000003450 ! has part B-cell lymphoma 6 protein intersection_of: CL:4030046 PR:000001203 ! lacks_plasma_membrane_part C-C chemokine receptor type 7 intersection_of: RO:0002104 PR:000001209 ! has plasma membrane part C-X-C chemokine receptor type 5 intersection_of: RO:0002104 PR:000001860 ! has plasma membrane part inducible T-cell costimulator intersection_of: RO:0002104 PR:000001919 ! has plasma membrane part programmed cell death protein 1 intersection_of: RO:0002215 GO:0002639 ! capable of positive regulation of immunoglobulin production intersection_of: RO:0002215 GO:0045830 ! capable of positive regulation of isotype switching relationship: BFO:0000051 PR:000003450 ! has part B-cell lymphoma 6 protein relationship: CL:4030046 PR:000001203 ! lacks_plasma_membrane_part C-C chemokine receptor type 7 relationship: RO:0002104 PR:000001209 ! has plasma membrane part C-X-C chemokine receptor type 5 relationship: RO:0002104 PR:000001860 ! has plasma membrane part inducible T-cell costimulator relationship: RO:0002104 PR:000001919 ! has plasma membrane part programmed cell death protein 1 relationship: RO:0002215 GO:0045830 ! capable of positive regulation of isotype switching property_value: RO:0002175 NCBITaxon:9606 property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2009-10-29T04:01:27Z [Term] id: CL:0002039 name: immature NK T cell stage I, mouse def: "A CD24-high, CD4-low, CD8-low, CD44-negative, NK1.1-negative NK T cell." [GOC:tfm, PMID:16087715, PMID:17589542, PMID:19423665, PMID:26802287, PMID:38440725] comment: The immature NK T cell stage” (I–IV) represents mouse-specific stages used to define iNKT cell development. The immature NK T cells in humans typically exhibit a CD161low; CD4+ phenotype. {xref="PMID:17589542"} subset: mouse_subset is_a: CL:0000914 {is_inferred="true"} ! immature NK T cell intersection_of: CL:0000914 ! immature NK T cell intersection_of: CL:4030046 PR:000001307 ! lacks_plasma_membrane_part CD44 molecule intersection_of: CL:4030046 PR:000001874 ! lacks_plasma_membrane_part KLRB1-like protein intersection_of: RO:0002162 NCBITaxon:10090 ! in taxon Mus musculus intersection_of: RO:0015015 PR:000001932 ! has high plasma membrane amount signal transducer CD24 intersection_of: RO:0015016 PR:000001004 ! has low plasma membrane amount CD4 molecule intersection_of: RO:0015016 PR:000025402 ! has low plasma membrane amount T cell receptor co-receptor CD8 relationship: CL:4030046 PR:000001307 ! lacks_plasma_membrane_part CD44 molecule relationship: CL:4030046 PR:000001874 ! lacks_plasma_membrane_part KLRB1-like protein relationship: RO:0002162 NCBITaxon:10090 ! in taxon Mus musculus relationship: RO:0015015 PR:000001932 ! has high plasma membrane amount signal transducer CD24 relationship: RO:0015016 PR:000001004 ! has low plasma membrane amount CD4 molecule relationship: RO:0015016 PR:000025402 ! has low plasma membrane amount T cell receptor co-receptor CD8 property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2009-10-29T04:09:16Z [Term] id: CL:0002040 name: immature NK T cell stage II, mouse def: "A CD24-low, CD44-negative, NK1.1-negative NK T cell." [GOC:tfm, http://www.immgen.org/index_content.html, PMID:16087715, PMID:17589542, PMID:19423665, PMID:26802287, PMID:38440725] comment: NKT.44-NK1.1-.Th was assigned as an exact synonym based on sorting strategy displayed at immgene.org. The immature NK T cell stage” (I–IV) represents mouse-specific stages used to define iNKT cell development. The immature NK T cells in humans typically exhibit a CD161low; CD4+ phenotype. {xref="PMID:17589542"} subset: mouse_subset synonym: "NKT.44-NK1.1-.Th" EXACT [] is_a: CL:0000914 {is_inferred="true"} ! immature NK T cell intersection_of: CL:0000914 ! immature NK T cell intersection_of: CL:4030046 PR:000001307 ! lacks_plasma_membrane_part CD44 molecule intersection_of: CL:4030046 PR:000001874 ! lacks_plasma_membrane_part KLRB1-like protein intersection_of: RO:0002162 NCBITaxon:10090 ! in taxon Mus musculus intersection_of: RO:0015016 PR:000001932 ! has low plasma membrane amount signal transducer CD24 relationship: CL:4030046 PR:000001307 ! lacks_plasma_membrane_part CD44 molecule relationship: CL:4030046 PR:000001874 ! lacks_plasma_membrane_part KLRB1-like protein relationship: RO:0002202 CL:0002039 ! develops from immature NK T cell stage I, mouse relationship: RO:0015016 PR:000001932 ! has low plasma membrane amount signal transducer CD24 property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2009-10-29T04:13:43Z [Term] id: CL:0002041 name: immature NK T cell stage III, mouse def: "A CD24-low, CD44-positive, DX5-low, NK1.1-negative NK T cell." [PMID:16087715, PMID:17589542, PMID:19423665, PMID:26802287, PMID:38440725] comment: The immature NK T cell stage” (I–IV) represents mouse-specific stages used to define iNKT cell development. The immature NK T cells in humans typically exhibit a CD161low; CD4+ phenotype. {xref="PMID:17589542"} subset: mouse_subset synonym: "NKT.44+.NK1.1-.Th" BROAD [] is_a: CL:0000914 {is_inferred="true"} ! immature NK T cell intersection_of: CL:0000914 ! immature NK T cell intersection_of: CL:4030046 PR:000001874 ! lacks_plasma_membrane_part KLRB1-like protein intersection_of: RO:0002104 PR:000001307 ! has plasma membrane part CD44 molecule intersection_of: RO:0002162 NCBITaxon:10090 ! in taxon Mus musculus intersection_of: RO:0015016 PR:000001008 ! has low plasma membrane amount integrin alpha-2 intersection_of: RO:0015016 PR:000001932 ! has low plasma membrane amount signal transducer CD24 relationship: CL:4030046 PR:000001874 ! lacks_plasma_membrane_part KLRB1-like protein relationship: RO:0002104 PR:000001307 ! has plasma membrane part CD44 molecule relationship: RO:0002202 CL:0002040 ! develops from immature NK T cell stage II, mouse relationship: RO:0015016 PR:000001008 ! has low plasma membrane amount integrin alpha-2 relationship: RO:0015016 PR:000001932 ! has low plasma membrane amount signal transducer CD24 property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2009-10-29T04:14:48Z [Term] id: CL:0002042 name: immature NK T cell stage IV, mouse def: "A CD24-low, CD44-positive, DX5-high, NK1.1-negative NK T cell." [GOC:tfm, http://www.immgen.org/index_content.html, PMID:16087715, PMID:17589542, PMID:19423665, PMID:26802287, PMID:38440725] comment: The immature NK T cell stage” (I–IV) represents mouse-specific stages used to define iNKT cell development. The immature NK T cells in humans typically exhibit a CD161low; CD4+ phenotype. {xref="PMID:17589542"} subset: mouse_subset synonym: "NKT.44+.NK1.1-.Th" BROAD [] is_a: CL:0000914 {is_inferred="true"} ! immature NK T cell intersection_of: CL:0000914 ! immature NK T cell intersection_of: CL:4030046 PR:000001874 ! lacks_plasma_membrane_part KLRB1-like protein intersection_of: RO:0002104 PR:000001307 ! has plasma membrane part CD44 molecule intersection_of: RO:0002162 NCBITaxon:10090 ! in taxon Mus musculus intersection_of: RO:0015015 PR:000001008 ! has high plasma membrane amount integrin alpha-2 intersection_of: RO:0015016 PR:000001932 ! has low plasma membrane amount signal transducer CD24 relationship: CL:4030046 PR:000001874 ! lacks_plasma_membrane_part KLRB1-like protein relationship: RO:0002104 PR:000001307 ! has plasma membrane part CD44 molecule relationship: RO:0002202 CL:0002041 ! develops from immature NK T cell stage III, mouse relationship: RO:0015015 PR:000001008 ! has high plasma membrane amount integrin alpha-2 relationship: RO:0015016 PR:000001932 ! has low plasma membrane amount signal transducer CD24 property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2009-10-29T04:17:38Z [Term] id: CL:0002043 name: CD34-positive, CD38-negative multipotent progenitor cell def: "A hematopoietic multipotent progenitor cell that is CD34-positive, CD38-negative, CD45RA-negative, and CD90-negative." [GOC:tfm, PMID:18371405, PMID:19022770] comment: Cell markers are associated with human hematopoietic multipotent progenitor cells. subset: human_subset subset: mouse_subset is_a: CL:0000837 {is_inferred="true"} ! hematopoietic multipotent progenitor cell intersection_of: CL:0000837 ! hematopoietic multipotent progenitor cell intersection_of: CL:4030046 PR:000001015 ! lacks_plasma_membrane_part receptor-type tyrosine-protein phosphatase C isoform CD45RA intersection_of: CL:4030046 PR:000001408 ! lacks_plasma_membrane_part ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 intersection_of: CL:4030046 PR:000001843 ! lacks_plasma_membrane_part Thy-1 membrane glycoprotein intersection_of: RO:0002104 PR:000001003 ! has plasma membrane part CD34 molecule relationship: CL:4030046 PR:000001015 ! lacks_plasma_membrane_part receptor-type tyrosine-protein phosphatase C isoform CD45RA relationship: CL:4030046 PR:000001408 ! lacks_plasma_membrane_part ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 relationship: CL:4030046 PR:000001843 ! lacks_plasma_membrane_part Thy-1 membrane glycoprotein relationship: RO:0002202 CL:0001024 ! develops from CD34-positive, CD38-negative hematopoietic stem cell property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-01-12T11:14:15Z [Term] id: CL:0002044 name: Kit-positive, integrin beta7-high basophil mast progenitor cell def: "A basophil mast progenitor cell that is Beta-7 integrin-high, Kit-positive FcRgammaII/III-positive and Sca1-negative." [GOC:ak, GOC:tfm] comment: Markers are associated with mouse cells. subset: human_subset subset: mouse_subset is_a: CL:0002028 {is_inferred="true"} ! basophil mast progenitor cell intersection_of: CL:0002028 ! basophil mast progenitor cell intersection_of: CL:4030046 PR:000002065 ! lacks_plasma_membrane_part mast/stem cell growth factor receptor intersection_of: CL:4030046 PR:000002979 ! lacks_plasma_membrane_part lymphocyte antigen 6A-2/6E-1 intersection_of: RO:0002104 PR:000001479 ! has plasma membrane part low affinity immunoglobulin gamma Fc region receptor II intersection_of: RO:0002104 PR:000001483 ! has plasma membrane part low affinity immunoglobulin gamma Fc region receptor III intersection_of: RO:0015015 PR:000009143 ! has high plasma membrane amount integrin beta-7 relationship: CL:4030046 PR:000002065 ! lacks_plasma_membrane_part mast/stem cell growth factor receptor relationship: CL:4030046 PR:000002979 ! lacks_plasma_membrane_part lymphocyte antigen 6A-2/6E-1 relationship: RO:0002104 PR:000001479 ! has plasma membrane part low affinity immunoglobulin gamma Fc region receptor II relationship: RO:0002104 PR:000001483 ! has plasma membrane part low affinity immunoglobulin gamma Fc region receptor III relationship: RO:0015015 PR:000009143 ! has high plasma membrane amount integrin beta-7 property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-04-27T01:22:38Z [Term] id: CL:0002045 name: fraction A pre-pro B cell def: "A pro-B cell that is CD45R/B220-positive, CD43-positive, HSA-low, BP-1-negative and Ly6c-negative. This cell type is also described as being lin-negative, AA4-positive, Kit-positive, IL7Ra-positive and CD45R-positive." [GOC:ak, GOC:tfm, http://www.immgen.org/index_content.html, PMID:12633665, PMID:17582343, PMID:37442242] comment: Markers associated with mouse cells. subset: cellxgene_subset subset: mouse_subset synonym: "fraction A" BROAD [] synonym: "pre pro B cell" RELATED [] is_a: CL:0000826 {is_inferred="true"} ! pro-B cell intersection_of: CL:0000826 ! pro-B cell intersection_of: CL:4030046 PR:000002039 ! lacks_plasma_membrane_part glutamyl aminopeptidase intersection_of: CL:4030046 PR:000002980 ! lacks_plasma_membrane_part lymphocyte antigen 6C2 intersection_of: RO:0002104 PR:000001015 ! has plasma membrane part receptor-type tyrosine-protein phosphatase C isoform CD45RA intersection_of: RO:0002104 PR:000001879 ! has plasma membrane part leukosialin intersection_of: RO:0002104 PR:000002037 ! has plasma membrane part complement component C1q receptor intersection_of: RO:0002104 PR:000002065 ! has plasma membrane part mast/stem cell growth factor receptor intersection_of: RO:0002162 NCBITaxon:10090 ! in taxon Mus musculus intersection_of: RO:0015016 PR:000001932 ! has low plasma membrane amount signal transducer CD24 relationship: CL:4030046 PR:000002039 ! lacks_plasma_membrane_part glutamyl aminopeptidase relationship: CL:4030046 PR:000002980 ! lacks_plasma_membrane_part lymphocyte antigen 6C2 relationship: RO:0002104 PR:000001015 ! has plasma membrane part receptor-type tyrosine-protein phosphatase C isoform CD45RA relationship: RO:0002104 PR:000001879 ! has plasma membrane part leukosialin relationship: RO:0002104 PR:000002037 ! has plasma membrane part complement component C1q receptor relationship: RO:0002104 PR:000002065 ! has plasma membrane part mast/stem cell growth factor receptor relationship: RO:0002162 NCBITaxon:10090 ! in taxon Mus musculus relationship: RO:0015016 PR:000001932 ! has low plasma membrane amount signal transducer CD24 property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-04-28T10:50:07Z [Term] id: CL:0002046 name: early pro-B cell def: "A pro-B cell that is CD22-positive, CD34-positive, CD38-positive and TdT-positive (has TdT activity). Pre-BCR is expressed on the cell surface. Cell is CD19-negative, CD20-negative, complement receptor type 2-negative and CD10-low. D-to-J recombination of the heavy chain occurs at this stage." [GOC:dsd, GOC:tfm, PMID:18432934] comment: Markers are commonly associated with human cells. These cells are also reportedly CD21-negative. Transcription factors: PU.1-positive, Ikaros-positive, E2A-positive, and PAX5-positive. subset: cellxgene_subset subset: human_subset subset: mouse_subset is_a: CL:0000826 {is_inferred="true"} ! pro-B cell intersection_of: CL:0000826 ! pro-B cell intersection_of: CL:4030046 PR:000001002 ! lacks_plasma_membrane_part CD19 molecule intersection_of: CL:4030046 PR:000001289 ! lacks_plasma_membrane_part membrane-spanning 4-domains subfamily A member 1 intersection_of: CL:4030046 PR:000001338 ! lacks_plasma_membrane_part complement receptor type 2 intersection_of: RO:0000056 GO:0071707 ! participates in immunoglobulin heavy chain V-D-J recombination intersection_of: RO:0002104 GO:0035369 ! has plasma membrane part pre-B cell receptor complex intersection_of: RO:0002104 PR:000001003 ! has plasma membrane part CD34 molecule intersection_of: RO:0002104 PR:000001288 ! has plasma membrane part B-cell receptor CD22 intersection_of: RO:0002104 PR:000001408 ! has plasma membrane part ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 intersection_of: RO:0015016 PR:000001898 ! has low plasma membrane amount neprilysin relationship: CL:4030046 PR:000001002 ! lacks_plasma_membrane_part CD19 molecule relationship: CL:4030046 PR:000001289 ! lacks_plasma_membrane_part membrane-spanning 4-domains subfamily A member 1 relationship: CL:4030046 PR:000001338 ! lacks_plasma_membrane_part complement receptor type 2 relationship: RO:0000056 GO:0071707 ! participates in immunoglobulin heavy chain V-D-J recombination relationship: RO:0002104 GO:0035369 ! has plasma membrane part pre-B cell receptor complex relationship: RO:0002104 PR:000001003 ! has plasma membrane part CD34 molecule relationship: RO:0002104 PR:000001288 ! has plasma membrane part B-cell receptor CD22 relationship: RO:0002104 PR:000001408 ! has plasma membrane part ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 relationship: RO:0015016 PR:000001898 ! has low plasma membrane amount neprilysin property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-04-28T11:19:11Z [Term] id: CL:0002047 name: fraction B precursor B cell def: "A precursor B cell that is CD45RA-positive, CD43-positive, CD24-positive and BP-1-negative." [GOC:ak, GOC:tfm, PMID:18432934, PMID:37442242] comment: Markers are commonly associated with mouse cells. These cells are also reportedly RAG1-positive and RAG2-positive. subset: mouse_subset synonym: "Fr. B" BROAD [] synonym: "Fraction B" BROAD [] is_a: CL:0002400 {is_inferred="true"} ! fraction B/C precursor B cell intersection_of: CL:0002400 ! fraction B/C precursor B cell intersection_of: CL:4030046 PR:000002039 ! lacks_plasma_membrane_part glutamyl aminopeptidase intersection_of: RO:0002104 PR:000001014 ! has plasma membrane part receptor-type tyrosine-protein phosphatase C isoform CD45RABC intersection_of: RO:0002104 PR:000001932 ! has plasma membrane part signal transducer CD24 relationship: CL:4030046 PR:000002039 ! lacks_plasma_membrane_part glutamyl aminopeptidase relationship: RO:0002104 PR:000001014 ! has plasma membrane part receptor-type tyrosine-protein phosphatase C isoform CD45RABC relationship: RO:0002202 CL:0002045 ! develops from fraction A pre-pro B cell property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-04-28T11:56:21Z [Term] id: CL:0002048 name: late pro-B cell def: "A pre-B cell precursor is CD19-low, CD22-positive , CD34-positive, CD38-positive." [GOC:dsd, GOC:tfm, PMID:18432934] comment: Late pro-B cells are also reportedly CD10-positive, CD20-negative, CD21-negative, and TdT-positive. Transcription factors: PU.1-positive, Ikaros-positive, E2A-positive, and PAX5-positive. subset: cellxgene_subset subset: human_subset subset: mouse_subset is_a: CL:0000817 {is_inferred="true"} ! precursor B cell intersection_of: CL:0000817 ! precursor B cell intersection_of: RO:0002104 PR:000001003 ! has plasma membrane part CD34 molecule intersection_of: RO:0002104 PR:000001288 ! has plasma membrane part B-cell receptor CD22 intersection_of: RO:0002104 PR:000001408 ! has plasma membrane part ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 intersection_of: RO:0015016 PR:000001002 ! has low plasma membrane amount CD19 molecule relationship: RO:0002104 PR:000001003 ! has plasma membrane part CD34 molecule relationship: RO:0002104 PR:000001288 ! has plasma membrane part B-cell receptor CD22 relationship: RO:0002104 PR:000001408 ! has plasma membrane part ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 relationship: RO:0002202 CL:0002046 ! develops from early pro-B cell relationship: RO:0015016 PR:000001002 ! has low plasma membrane amount CD19 molecule property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-04-28T12:06:06Z [Term] id: CL:0002049 name: fraction C precursor B cell def: "A precursor B cell that is CD45R-positive, CD43-positive, CD24-positive, and BP-positive. Intracellularly expression of surrogate light chain, Rag1 and Rag2, TdT, occurs while there is no expression of mu heavy chain." [GOC:tfm, PMID:17582343, PMID:37442242] subset: mouse_subset synonym: "Fraction C" RELATED [] is_a: CL:0002400 {is_inferred="true"} ! fraction B/C precursor B cell intersection_of: CL:0002400 ! fraction B/C precursor B cell intersection_of: BFO:0000051 PR:000001858 ! has part immunoglobulin iota chain intersection_of: BFO:0000051 PR:000001859 ! has part immunoglobulin lambda-like polypeptide 1 intersection_of: CL:4030044 GO:0071707 ! has_not_completed immunoglobulin heavy chain V-D-J recombination intersection_of: RO:0002104 PR:000001014 ! has plasma membrane part receptor-type tyrosine-protein phosphatase C isoform CD45RABC intersection_of: RO:0002104 PR:000001932 ! has plasma membrane part signal transducer CD24 intersection_of: RO:0002104 PR:000002039 ! has plasma membrane part glutamyl aminopeptidase intersection_of: RO:0002104 PR:000003457 ! has plasma membrane part V(D)J recombination-activating protein 1 intersection_of: RO:0002104 PR:000003460 ! has plasma membrane part V(D)J recombination-activating protein 2 relationship: BFO:0000051 PR:000001858 ! has part immunoglobulin iota chain relationship: BFO:0000051 PR:000001859 ! has part immunoglobulin lambda-like polypeptide 1 relationship: CL:4030044 GO:0071707 ! has_not_completed immunoglobulin heavy chain V-D-J recombination relationship: RO:0002104 PR:000001014 ! has plasma membrane part receptor-type tyrosine-protein phosphatase C isoform CD45RABC relationship: RO:0002104 PR:000002039 ! has plasma membrane part glutamyl aminopeptidase relationship: RO:0002104 PR:000003457 ! has plasma membrane part V(D)J recombination-activating protein 1 relationship: RO:0002104 PR:000003460 ! has plasma membrane part V(D)J recombination-activating protein 2 relationship: RO:0002202 CL:0002047 ! develops from fraction B precursor B cell property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-04-28T02:04:01Z [Term] id: CL:0002050 name: fraction C' precursor B cell def: "A pre-BCR-positive precursor B cell that is CD24-high, CD25-positive, CD43-positive, CD45R-positive and BP-positive." [GOC:tfm, PMID:17582343, PMID:37442242] subset: mouse_subset synonym: "Fr. C'" BROAD [] synonym: "Fraction C-prime" BROAD [] is_a: CL:0000817 {is_inferred="true"} ! precursor B cell intersection_of: CL:0000817 ! precursor B cell intersection_of: RO:0002104 GO:0035369 ! has plasma membrane part pre-B cell receptor complex intersection_of: RO:0002104 PR:000001014 ! has plasma membrane part receptor-type tyrosine-protein phosphatase C isoform CD45RABC intersection_of: RO:0002104 PR:000001380 ! has plasma membrane part interleukin-2 receptor subunit alpha intersection_of: RO:0002104 PR:000001879 ! has plasma membrane part leukosialin intersection_of: RO:0002104 PR:000002039 ! has plasma membrane part glutamyl aminopeptidase intersection_of: RO:0002162 NCBITaxon:10090 ! in taxon Mus musculus intersection_of: RO:0015015 PR:000001932 ! has high plasma membrane amount signal transducer CD24 relationship: RO:0002104 GO:0035369 ! has plasma membrane part pre-B cell receptor complex relationship: RO:0002104 PR:000001014 ! has plasma membrane part receptor-type tyrosine-protein phosphatase C isoform CD45RABC relationship: RO:0002104 PR:000001380 ! has plasma membrane part interleukin-2 receptor subunit alpha relationship: RO:0002104 PR:000001879 ! has plasma membrane part leukosialin relationship: RO:0002104 PR:000002039 ! has plasma membrane part glutamyl aminopeptidase relationship: RO:0002202 CL:0002049 ! develops from fraction C precursor B cell relationship: RO:0015015 PR:000001932 ! has high plasma membrane amount signal transducer CD24 property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-04-28T02:13:46Z [Term] id: CL:0002051 name: CD38-high pre-BCR positive cell def: "A pre-BCR positive B cell that is CD38-high." [GOC:tfm, PMID:18432934] comment: Markers are associated with human cells. subset: human_subset subset: mouse_subset synonym: "large pre-B cell type I" RELATED [] is_a: CL:0000952 {is_inferred="true"} ! preBCR-positive large pre-B-II cell intersection_of: CL:0000952 ! preBCR-positive large pre-B-II cell intersection_of: RO:0002104 PR:000001288 ! has plasma membrane part B-cell receptor CD22 intersection_of: RO:0015015 PR:000001408 ! has high plasma membrane amount ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 relationship: RO:0002104 PR:000001288 ! has plasma membrane part B-cell receptor CD22 relationship: RO:0002202 CL:0002048 ! develops from late pro-B cell relationship: RO:0015015 PR:000001408 ! has high plasma membrane amount ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-04-28T02:27:47Z [Term] id: CL:0002052 name: fraction D precursor B cell def: "A pre-B cell that is pre-BCR-negative, and the kappa- and lambda- light immunoglobulin light chain-negative, CD43-low, and is BP-1-positive, CD45R-positive and CD25-positive. This cell type is also described as being AA4-positive, IgM-negative, CD19-positive, CD43-low/negative, and HSA-positive." [GOC:ak, GOC:dsd, GOC:tfm, http://www.immgen.org/index_content.html, PMID:17582343, PMID:18432934, PMID:37442242] comment: Fraction D precursor B cells are also reportedly CD24-positive and sIgD-negative. subset: mouse_subset synonym: "Fr. D" BROAD [] synonym: "fraction D pre-B cell" EXACT [GOC:tfm] is_a: CL:0002400 ! fraction B/C precursor B cell intersection_of: CL:0000817 ! precursor B cell intersection_of: CL:4030044 GO:0071708 ! has_not_completed immunoglobulin light chain V-J recombination intersection_of: CL:4030046 GO:0035369 ! lacks_plasma_membrane_part pre-B cell receptor complex intersection_of: RO:0002104 PR:000001002 ! has plasma membrane part CD19 molecule intersection_of: RO:0002104 PR:000001014 ! has plasma membrane part receptor-type tyrosine-protein phosphatase C isoform CD45RABC intersection_of: RO:0002104 PR:000001380 ! has plasma membrane part interleukin-2 receptor subunit alpha intersection_of: RO:0002104 PR:000001932 ! has plasma membrane part signal transducer CD24 intersection_of: RO:0002104 PR:000002037 ! has plasma membrane part complement component C1q receptor intersection_of: RO:0002104 PR:000002039 ! has plasma membrane part glutamyl aminopeptidase intersection_of: RO:0002162 NCBITaxon:10090 ! in taxon Mus musculus intersection_of: RO:0015016 PR:000001879 ! has low plasma membrane amount leukosialin relationship: CL:4030044 GO:0071708 ! has_not_completed immunoglobulin light chain V-J recombination relationship: CL:4030046 GO:0035369 ! lacks_plasma_membrane_part pre-B cell receptor complex relationship: RO:0002104 PR:000001014 ! has plasma membrane part receptor-type tyrosine-protein phosphatase C isoform CD45RABC relationship: RO:0002104 PR:000001380 ! has plasma membrane part interleukin-2 receptor subunit alpha relationship: RO:0002104 PR:000002039 ! has plasma membrane part glutamyl aminopeptidase relationship: RO:0002202 CL:0002050 ! develops from fraction C' precursor B cell relationship: RO:0015016 PR:000001879 ! has low plasma membrane amount leukosialin property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-04-28T02:55:16Z [Term] id: CL:0002053 name: CD22-positive, CD38-low small pre-B cell def: "A small pre-B cell that is CD22-positive and CD38-low." [GOC:tfm, PMID:18432934] comment: Markers are associated with human cell. RAG expression maybe diminishing. subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "small pre-B cell" EXACT [] is_a: CL:0000954 {is_inferred="true"} ! small pre-B-II cell intersection_of: CL:0000954 ! small pre-B-II cell intersection_of: RO:0002104 PR:000001288 ! has plasma membrane part B-cell receptor CD22 intersection_of: RO:0015016 PR:000001408 ! has low plasma membrane amount ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 relationship: RO:0002104 PR:000001288 ! has plasma membrane part B-cell receptor CD22 relationship: RO:0002202 CL:0002051 ! develops from CD38-high pre-BCR positive cell relationship: RO:0015016 PR:000001408 ! has low plasma membrane amount ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-04-28T03:04:48Z [Term] id: CL:0002054 name: fraction E immature B cell def: "An immature B cell that is IgM-positive, CD45R-positive, CD43-low, CD25-negative, and CD127-negative. This cell type has also been described as being AA4-positive, IgM-positive, CD19-positive, CD43-low/negative, and HSA-positive." [GOC:ak, GOC:dsd, GOC:tfm, PMID:17582343, PMID:18432934, PMID:37442242] comment: Markers associated with mouse cells. These cells are also reportedly sIgD-negative. subset: mouse_subset is_a: CL:0000816 {is_inferred="true"} ! immature B cell intersection_of: CL:0000816 ! immature B cell intersection_of: CL:4030046 PR:000001380 ! lacks_plasma_membrane_part interleukin-2 receptor subunit alpha intersection_of: CL:4030046 PR:000001869 ! lacks_plasma_membrane_part interleukin-7 receptor subunit alpha intersection_of: RO:0002104 PR:000001002 ! has plasma membrane part CD19 molecule intersection_of: RO:0002104 PR:000001932 ! has plasma membrane part signal transducer CD24 intersection_of: RO:0002104 PR:000002037 ! has plasma membrane part complement component C1q receptor intersection_of: RO:0002162 NCBITaxon:10090 ! in taxon Mus musculus intersection_of: RO:0015016 PR:000001879 ! has low plasma membrane amount leukosialin relationship: CL:4030046 PR:000001380 ! lacks_plasma_membrane_part interleukin-2 receptor subunit alpha relationship: CL:4030046 PR:000001869 ! lacks_plasma_membrane_part interleukin-7 receptor subunit alpha relationship: RO:0002104 PR:000001932 ! has plasma membrane part signal transducer CD24 relationship: RO:0002104 PR:000002037 ! has plasma membrane part complement component C1q receptor relationship: RO:0002202 CL:0002052 ! develops from fraction D precursor B cell relationship: RO:0015016 PR:000001879 ! has low plasma membrane amount leukosialin property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-04-28T03:13:47Z [Term] id: CL:0002055 name: CD38-negative immature B cell def: "An immature B cell that is CD38-negative, CD10-low, CD21-low, and CD22-high." [GOC:tfm, PMID:18432934] comment: Markers are associated with human cell type. subset: human_subset subset: mouse_subset is_a: CL:0000816 {is_inferred="true"} ! immature B cell intersection_of: CL:0000816 ! immature B cell intersection_of: CL:4030046 PR:000001408 ! lacks_plasma_membrane_part ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 intersection_of: RO:0015015 PR:000001288 ! has high plasma membrane amount B-cell receptor CD22 intersection_of: RO:0015016 PR:000001338 ! has low plasma membrane amount complement receptor type 2 intersection_of: RO:0015016 PR:000001898 ! has low plasma membrane amount neprilysin relationship: CL:4030046 PR:000001408 ! lacks_plasma_membrane_part ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 relationship: RO:0002202 CL:0002053 ! develops from CD22-positive, CD38-low small pre-B cell relationship: RO:0015015 PR:000001288 ! has high plasma membrane amount B-cell receptor CD22 relationship: RO:0015016 PR:000001338 ! has low plasma membrane amount complement receptor type 2 relationship: RO:0015016 PR:000001898 ! has low plasma membrane amount neprilysin property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-04-28T03:19:14Z [Term] id: CL:0002056 name: fraction F mature B cell def: "A mature B cell subset originally defined as having being CD45R-positive, IgM-positive, IgD-positive and CD43-negative. Subsequent research demonstrated being CD21-positive and CD23-negative and CD93 negative." [GOC:tfm, PMID:17582343, PMID:37442242] subset: mouse_subset is_a: CL:0000822 ! B-2 B cell intersection_of: CL:0000785 ! mature B cell intersection_of: CL:4030046 PR:000001879 ! lacks_plasma_membrane_part leukosialin intersection_of: CL:4030046 PR:000001880 ! lacks_plasma_membrane_part low affinity immunoglobulin epsilon Fc receptor intersection_of: CL:4030046 PR:000002037 ! lacks_plasma_membrane_part complement component C1q receptor intersection_of: RO:0002104 GO:0071738 ! has plasma membrane part IgD immunoglobulin complex intersection_of: RO:0002104 GO:0071753 ! has plasma membrane part IgM immunoglobulin complex intersection_of: RO:0002104 PR:000001014 ! has plasma membrane part receptor-type tyrosine-protein phosphatase C isoform CD45RABC intersection_of: RO:0002104 PR:000001289 ! has plasma membrane part membrane-spanning 4-domains subfamily A member 1 intersection_of: RO:0002104 PR:000001338 ! has plasma membrane part complement receptor type 2 intersection_of: RO:0002162 NCBITaxon:10090 ! in taxon Mus musculus relationship: CL:4030046 PR:000001880 ! lacks_plasma_membrane_part low affinity immunoglobulin epsilon Fc receptor relationship: CL:4030046 PR:000002037 ! lacks_plasma_membrane_part complement component C1q receptor relationship: RO:0002104 GO:0071738 ! has plasma membrane part IgD immunoglobulin complex relationship: RO:0002104 GO:0071753 ! has plasma membrane part IgM immunoglobulin complex relationship: RO:0002104 PR:000001014 ! has plasma membrane part receptor-type tyrosine-protein phosphatase C isoform CD45RABC relationship: RO:0002104 PR:000001338 ! has plasma membrane part complement receptor type 2 relationship: RO:0002202 CL:0002054 ! develops from fraction E immature B cell property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-04-30T03:01:48Z [Term] id: CL:0002057 name: CD14-positive, CD16-negative classical monocyte def: "A classical monocyte that is CD14-positive, CD16-negative, CD64-positive, CD163-positive." [GOC:add, GOC:tfm, PMID:15615263, PMID:1706877, PMID:19689341, PMID:22343568] comment: This cell type is compatible with the HIPC Lyoplate markers for 'CD16- monocyte'. The markers used in the definition are associated with human monocytes. subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "CD16- monocyte" EXACT [PMID:22343568] synonym: "CD16-negative monocyte" EXACT [] is_a: CL:0000860 {is_inferred="true"} ! classical monocyte is_a: CL:0001054 ! CD14-positive monocyte intersection_of: CL:0000860 ! classical monocyte intersection_of: CL:4030046 PR:000001483 ! lacks_plasma_membrane_part low affinity immunoglobulin gamma Fc region receptor III intersection_of: RO:0002104 PR:000001465 ! has plasma membrane part high affinity immunoglobulin gamma Fc receptor I intersection_of: RO:0002104 PR:000001889 ! has plasma membrane part CD14 molecule intersection_of: RO:0002104 PR:000001925 ! has plasma membrane part scavenger receptor cysteine-rich type 1 protein M130 relationship: CL:4030046 PR:000001483 ! lacks_plasma_membrane_part low affinity immunoglobulin gamma Fc region receptor III relationship: RO:0002104 PR:000001465 ! has plasma membrane part high affinity immunoglobulin gamma Fc receptor I relationship: RO:0002104 PR:000001925 ! has plasma membrane part scavenger receptor cysteine-rich type 1 protein M130 property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-06-05T08:25:41Z [Term] id: CL:0002058 name: Gr1-low non-classical monocyte def: "A resident monocyte that is Gr-1 low, CD43-positive, and CX3CR1-positive." [GOC:tfm, PMID:8890901] comment: Markers are associated with mice. The Gr epitope is used to describe this cell type is found on both Ly6c and Ly6g. However, its the Ly6c that is considered the specific marker, and thus used in the cross-product. Also, this cell-type is sometimes described as being Gr1-negative. subset: mouse_subset is_a: CL:0000875 {is_inferred="true"} ! non-classical monocyte is_a: CL:0002398 ! Gr1-positive, CD43-positive monocyte intersection_of: CL:0000875 ! non-classical monocyte intersection_of: CL:4030046 PR:000001014 ! lacks_plasma_membrane_part receptor-type tyrosine-protein phosphatase C isoform CD45RABC intersection_of: RO:0002104 PR:000001012 ! has plasma membrane part integrin alpha-M intersection_of: RO:0002104 PR:000001206 ! has plasma membrane part CX3C chemokine receptor 1 intersection_of: RO:0002104 PR:000001879 ! has plasma membrane part leukosialin intersection_of: RO:0002104 PR:000002062 ! has plasma membrane part macrophage colony-stimulating factor 1 receptor intersection_of: RO:0015016 PR:000001199 ! has low plasma membrane amount C-C chemokine receptor type 2 intersection_of: RO:0015016 PR:000002980 ! has low plasma membrane amount lymphocyte antigen 6C2 relationship: CL:4030046 PR:000001014 ! lacks_plasma_membrane_part receptor-type tyrosine-protein phosphatase C isoform CD45RABC relationship: RO:0002202 CL:0002398 ! develops from Gr1-positive, CD43-positive monocyte relationship: RO:0015016 PR:000001199 ! has low plasma membrane amount C-C chemokine receptor type 2 relationship: RO:0015016 PR:000002980 ! has low plasma membrane amount lymphocyte antigen 6C2 property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-06-05T08:25:44Z [Term] id: CL:0002059 name: CD8-alpha-positive thymic conventional dendritic cell def: "A conventional thymic dendritic cell that is CD8-alpha-positive." [GOC:tfm, http://www.immgen.org/index_content.html, PMID:19273629] subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "CD8alpha-alpha-positive thymic conventional dendritic cell" EXACT [] synonym: "DC.8+.Th" EXACT [] is_a: CL:0000941 {is_inferred="true"} ! thymic conventional dendritic cell intersection_of: CL:0000941 ! thymic conventional dendritic cell intersection_of: RO:0002104 PR:000001084 ! has plasma membrane part T-cell surface glycoprotein CD8 alpha chain relationship: RO:0002104 PR:000001084 ! has plasma membrane part T-cell surface glycoprotein CD8 alpha chain property_value: RO:0002175 NCBITaxon:9606 property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-06-07T02:48:36Z [Term] id: CL:0002060 name: melanophage def: "A melanin-containing macrophage that obtains the pigment by phagocytosis of melanosomes." [GOC:tfm, PMID:20479296, PMID:2943821] subset: human_subset subset: mouse_subset is_a: CL:0000864 {is_inferred="true"} ! tissue-resident macrophage relationship: BFO:0000050 UBERON:0002097 ! part of skin of body property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-06-22T10:46:12Z [Term] id: CL:0002061 name: T-helper 9 cell def: "A T-helper cell that is characterized by secreting interleukin 9 and responding to helminth infections. This cell-type can derives from Th2 cells in the presence of TGF-beta and IL-4. Th2 cytokine production is surpressed." [GOC:tfm, PMID:18931678, PMID:19604299, PMID:20154671] subset: human_subset subset: mouse_subset synonym: "T helper cells type 9" EXACT [] synonym: "T(H)-9 cell" EXACT [] synonym: "Th9" EXACT [PMID:18931678] is_a: CL:0000492 {is_inferred="true"} ! CD4-positive helper T cell intersection_of: CL:0000492 ! CD4-positive helper T cell intersection_of: RO:0002104 PR:000008982 ! has plasma membrane part interleukin-17 receptor B intersection_of: RO:0002215 GO:0002215 ! capable of defense response to nematode intersection_of: RO:0002215 GO:0032638 ! capable of interleukin-9 production relationship: RO:0002104 PR:000008982 ! has plasma membrane part interleukin-17 receptor B relationship: RO:0002215 GO:0002215 ! capable of defense response to nematode relationship: RO:0002215 GO:0032638 ! capable of interleukin-9 production property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-06-22T11:18:44Z [Term] id: CL:0002062 name: pulmonary alveolar type 1 cell def: "A squamous pulmonary alveolar epithelial cell that is flattened and branched. A pulmonary alveolar type 1 cell covers more than 98% of the alveolar surface. This large cell has thin (50-100 nm) cytoplasmic extensions to form the air-blood barrier essential for normal gas exchange." [GOC:tfm, http://www.copewithcytokines.de, PMID:20054144, PMID:29463737] comment: The marker set AGER can identify the Human cell type pulmonary alveolar type 1 cell in the lung with a confidence of 0.85 (NS-Forest FBeta value). {xref="https://doi.org/10.5281/zenodo.11165918"} subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "AT1" RELATED OMO:0003000 [PMID:29463737] synonym: "ATI" RELATED OMO:0003000 [] synonym: "lung type 1 cells" EXACT [] synonym: "membranous pneumocytes" EXACT [] synonym: "pulmonary alveolar type I cell" EXACT [] synonym: "small alveolar cells" EXACT [] synonym: "squamous alveolar cell" EXACT [] synonym: "squamous alveolar lining cell" EXACT [] synonym: "type 1 alveolar epithelial cells" EXACT [] synonym: "type 1 pneumocyte" EXACT [PMID:32491474] synonym: "type I alveolar cells" EXACT [] synonym: "type I alveolar epithelial cells" EXACT [] synonym: "type I pneumocyte" EXACT [] xref: BTO:0000780 xref: FMA:62500 is_a: CL:0000076 ! squamous epithelial cell is_a: CL:0000322 ! pulmonary alveolar epithelial cell intersection_of: CL:0000322 ! pulmonary alveolar epithelial cell intersection_of: RO:0002215 GO:0007585 ! capable of respiratory gaseous exchange by respiratory system relationship: RO:0002215 GO:0007585 ! capable of respiratory gaseous exchange by respiratory system relationship: RO:0015004 CLM:1000008 ! has characterizing marker set NS forest marker set of pulmonary alveolar type 1 cell (Human lung). property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/2d-ftu/lung-pulmonary-alveolus/v1.3/assets/2d-ftu-lung-pulmonary-alveolus.png" xsd:string {terms:licence="http://creativecommons.org/licenses/by/4.0/", xref="doi:10.48539/HBM558.BZLS.992"} property_value: RO:0002175 NCBITaxon:9606 property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0002062" xsd:string {name="pulmonary alveolar type 1 cell on CELLxGENE CellGuide"} property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 property_value: terms:description "Type I pneumocytes, also known as alveolar epithelial cells type I, are specialized cells lining the alveoli within the lungs. Their strategic positioning within the air sacs of the lungs plays a crucial role in gaseous exchange. They cover around 90-95% of the alveolar surface, yet make up only about 40% of the total number of cells in the alveolus. Their unique squamous, or flattened, shape allows for a vast surface area that enables a fast rate of diffusion of respiratory gases, oxygen and carbon dioxide.\nFunctionally, type I pneumocytes serve as the site for the critical exchange of gases between the air in the lungs and the blood in the capillaries. These cells are in direct contact with pulmonary capillaries and are therefore primarily responsible for oxygen passing into the bloodstream and carbon dioxide being removed from the bloodstream. It is important to note that these cells are extremely thin and fragile, a feature that promotes easy passage of gases but also renders the cells susceptible to damage.\nA unique critical feature of type I pneumocytes is their inability to divide and proliferate. Should damage to these cells occur, repair and replenishment is addressed through the conversion of another cell type, known as type II pneumocytes, into type I pneumocytes. The role of type I cells is thus highly specific, and strictly aligned with enabling efficient respiration - an essential process for all aerobic organisms.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1016/B978-0-7216-0186-1.50012-0", xref="DOI:10.1165/rcmb.2021-0421OC", xref="DOI:10.1242/jcs.235556", xref="https://www.ncbi.nlm.nih.gov/books/NBK557542/"} creation_date: 2010-06-23T04:37:54Z [Term] id: CL:0002063 name: pulmonary alveolar type 2 cell def: "A pulmonary alveolar epithelial cell that modulates the fluid surrounding the alveolar epithelium by secreting and recycling surfactants via specialized organelles called alveolar lamellar bodies. This cell type also contributes to tissue repair and can differentiate after injury into a pulmonary alveolar type 1 cell. This cuboidal cell is thicker than squamous alveolar cells, has a rounded apical surface that projects above the level of the surrounding epithelium, and its free surface is covered by short microvilli." [GOC:tfm, http://www.copewithcytokines.de, ISBN:0412046911, PMID:36138472, PMID:8540632] comment: The marker set SFTPA1 can identify the Human cell type pulmonary alveolar type 2 cell in the lung with a confidence of 0.95 (NS-Forest FBeta value). {xref="https://doi.org/10.5281/zenodo.11165918"} subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "AT2" RELATED OMO:0003000 [PMID:36138472] synonym: "ATII" RELATED OMO:0003000 [] synonym: "cuboidal type II cell" EXACT [] synonym: "granular pneumocyte" EXACT [] synonym: "great alveolar cell" EXACT [] synonym: "lung type 2 cell" EXACT [] synonym: "lung type II cell" RELATED [] synonym: "TII" RELATED [] synonym: "type 2 alveolar epithelial cell" EXACT [] synonym: "type 2 alveolocyte" EXACT [] synonym: "type 2 pneumocyte" EXACT [] synonym: "type II alveolar cell" EXACT [] synonym: "type II alveolar epithelial cell" EXACT [] synonym: "type II alveolocyte" EXACT [] synonym: "type II pneumocyte" EXACT [PMID:32491474] xref: BTO:0000538 xref: FMA:62501 is_a: CL:0000157 ! surfactant secreting cell is_a: CL:0000322 ! pulmonary alveolar epithelial cell is_a: CL:0008055 ! respiratory tract secretory epithelial cell is_a: CL:1000272 ! lung secretory cell intersection_of: CL:0000322 ! pulmonary alveolar epithelial cell intersection_of: RO:0002215 GO:0032940 ! capable of secretion by cell intersection_of: RO:0002215 GO:0043129 ! capable of surfactant homeostasis relationship: BFO:0000051 GO:0097208 ! has part alveolar lamellar body relationship: RO:0000053 PATO:0001872 ! has characteristic cuboid relationship: RO:0002202 CL:4040003 ! develops from fetal pre-type II pulmonary alveolar epithelial cell relationship: RO:0015004 CLM:1000009 ! has characterizing marker set NS forest marker set of pulmonary alveolar type 2 cell (Human lung). property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/2d-ftu/lung-pulmonary-alveolus/v1.3/assets/2d-ftu-lung-pulmonary-alveolus.png" xsd:string {terms:licence="http://creativecommons.org/licenses/by/4.0/", xref="doi:10.48539/HBM558.BZLS.992"} property_value: RO:0002175 NCBITaxon:9606 property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-06-24T12:04:13Z [Term] id: CL:0002064 name: pancreatic acinar cell def: "A secretory cell found in pancreatic acini that secretes digestive enzymes and mucins. This cell is a typical zymogenic cell, have a basal nucleus and basophilic cytoplasm consisting of regular arrays of granular endoplasmic reticulum with mitochondria and dense secretory granules." [GOC:tfm, http://www.copewithcytokines.de/cope.cgi?key=pancreatic%20acinar%20cells, ISBN:0517223651, PMID:20395539] subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "acinar cell of pancreas" EXACT [] xref: BTO:0000028 xref: CALOHA:TS-0737 xref: FMA:63032 xref: ZFA:0005739 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000622 {is_inferred="true"} ! acinar cell is_a: CL:1001599 ! pancreas exocrine glandular cell intersection_of: CL:0000622 ! acinar cell intersection_of: BFO:0000050 UBERON:0001263 ! part of pancreatic acinus relationship: BFO:0000050 UBERON:0001263 ! part of pancreatic acinus relationship: BFO:0000051 GO:0042589 ! has part zymogen granule membrane property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/2d-ftu/pancreas-pancreatic-acinus/v1.2/assets/2d-ftu-pancreas-pancreatic-acinus.png" xsd:string {terms:licence="http://creativecommons.org/licenses/by/4.0/", xref="doi:10.48539/HBM586.MNXV.276"} property_value: RO:0002175 NCBITaxon:9606 property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0002064" xsd:string {name="pancreatic acinar cell on CELLxGENE CellGuide"} property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 property_value: terms:description "Pancreatic acinar cells are the functional units of the exocrine pancreas. These cells are structurally arranged in small clusters - or acini - with a small central lumen, and their primary function is to produce and secrete enzymes that facilitate digestion of proteins, carbohydrates, and fats within the small intestine.\nSome of the most important digestive enzymes synthesized by the pancreatic acinar cells include amylase, which digests carbohydrates, lipase, which breaks down fats, and several proteases such as trypsin and chymotrypsin which are vital for the digestion of proteins. Importantly, these enzymes are produced as proenzymes or zymogens to avoid autolysis, or the breakdown of the pancreas itself.\nThe release of these enzymes by the pancreatic acinar cells is strictly regulated by hormones and neurochemicals. Cholecystokinin (CCK) released from the enteroendocrine cells in the duodenum cause the release of these enzymes. Moreover, acinar cells also respond to another hormone, secretin, by releasing bicarbonate-rich fluid which helps to neutralize the gastric acid in the duodenum. \nDysregulation in the function of pancreatic acinar cells can lead to severe health issues, including pancreatitis, which is characterized by inflammatory damage to the organ due to the premature activation of digestive enzymes.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1016/0165-6147(89)90192-2", xref="DOI:10.1038/nrgastro.2013.36", xref="DOI:10.1097/01.mog.0000239863.96833.c0", xref="https://www.ncbi.nlm.nih.gov/books/NBK54134/"} creation_date: 2010-06-24T03:16:29Z [Term] id: CL:0002066 name: Feyrter cell def: "A neuroendocrine cell found in the epithelium of the lungs and respiratory tract. This cell type is rounded or elliptical in shape, situated mainly in the basal part of the epithelium; regulates bronchial secretion, smooth muscle contraction, lobular growth, ciliary activity and chemoreception. Cell has an electron-lucent cytoplasm, contains numerous dense-cored vesicles with a clear halo between the core and the limiting membrane." [GOC:tfm, ISBN:0412046911, ISBN:0517223651] subset: human_subset subset: mouse_subset synonym: "bronchiolar Kulchitsky cell" EXACT [] synonym: "Kultschitzky cell of bronchiole" EXACT [] synonym: "P cell" RELATED OMO:0003000 [] synonym: "respiratory enterochromaffin cell" EXACT [] xref: FMA:14118 is_a: CL:0000165 ! neuroendocrine cell property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-06-28T08:24:30Z [Term] id: CL:0002067 name: type A enteroendocrine cell def: "An enteroendocrine cell that produces glucagon." [GOC:tfm, ISBN:0412046911] subset: cellxgene_subset subset: human_subset subset: mouse_subset xref: FMA:62939 is_a: CL:0000164 ! enteroendocrine cell is_a: CL:0000170 ! glucagon secreting cell intersection_of: CL:0000164 ! enteroendocrine cell intersection_of: RO:0002215 GO:0070091 ! capable of glucagon secretion property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0002067" xsd:string {name="type A enteroendocrine cell on CELLxGENE CellGuide"} property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 property_value: terms:description "Type A enteroendocrine cells, also known as alpha cells or A cells, are a species of endocrine cells primarily located in the pancreatic islets of Langerhans; they have also been identified within the lining of the stomach. Functionally, these cells are pivotal in glucose metabolism and homeostasis, accounting for about 20% of the total population of cells in the pancreatic islets. \nThe primary role of type A enteroendocrine cells involves the synthesis, storage, and secretion of the peptide hormone glucagon, which is critical in energy regulation throughout the body. In response to a decrease in blood glucose levels, the pancreatic A cells are stimulated to secrete glucagon into the bloodstream. Glucagon acts on its target cells, mainly in the liver, to stimulate glycogenolysis and gluconeogenesis processes, thereby increasing blood glucose levels back to normal. In this way, pancreatic A cells play an integral role in maintaining glucose homeostasis and preventing hypoglycemia.\nPancreatic A cells also participate in the local regulation of islet activities as glucagon acts through glucagon receptors on A, B and D type cells within the islets. Recent studies have also shown that Pancreatic A cells play a role in the generation and regeneration of B type cells. Following beta cell injuries pancreatic A cells increase in numbers and produce Glucagon-like peptide-1 (GLP-1), which increases the proliferation and cytoprotection of beta cells. In response to extreme injury of B type cells pancreatic A cells can transform (transdifferentiate) into functioning B type cells.\nUntil recently, glucagon has been considered a pancreas-specific hormone; however, extrapancreatic glucagon has been reported in patients who had undergone complete, and glucagon-positive cells been identified in the human stomach, indicating that Type A enteroendocrine cells are not restricted to the pancreas.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1016/j.diabres.2018.06.013", xref="DOI:10.1210/en.2016-1748", xref="DOI:10.2337/db15-1541", xref="DOI:10.2337/dbi19-0002", xref="DOI:10.3389/fphys.2012.00349/full"} creation_date: 2010-09-10T10:48:54Z [Term] id: CL:0002068 name: Purkinje myocyte def: "Specialized cardiac myocyte that is subendocardially interspersed with the regular cardiac muscle cell. They are uninucleate cylindrical cells, associated end-to-end in long rows, continue from the node to the atrioventricular bundle; relatively short compared to ordinary myocytes but are nearly twice their diameter." [FMA:0412046911, GOC:tfm, PMID:19939742] subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "myocytus conducens cardiacus" EXACT [] synonym: "Purkinje cell fiber" EXACT [] synonym: "Purkinje muscle cell" EXACT [] xref: BTO:0001032 xref: FMA:14146 is_a: CL:0002086 ! specialized cardiac myocyte property_value: RO:0002175 NCBITaxon:9606 property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-06-28T08:36:15Z [Term] id: CL:0002069 name: type II vestibular sensory cell def: "Mostly cylindrical, resemble Type 1 in their contents and the presence of a kinocilium and stereocilium apically; much greater variation in size, some almost span the entire thickness of the sensory epithelium, while others are smaller than Type 1; receive multiple efferent nerve boutons around their bases as well as afferent endings, which are small expansions rather than chalices." [GOC:tfm, ISBN:0517223651] subset: human_subset subset: mouse_subset synonym: "type 2 vestibular hair cell" EXACT [] synonym: "type 2 vestibular sensory cell" EXACT [] synonym: "type II hair cell" EXACT [] xref: FMA:67909 is_a: CL:0000609 ! vestibular hair cell property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-06-29T09:58:13Z [Term] id: CL:0002070 name: type I vestibular sensory cell def: "Bottle-shaped with narrow neck; broad, rounded basal portion where nucleus is located; stereocilia and a single kinocilium is present apically; receive nerve bouton at their base from an afferent cup-shaped (chalice or calyx) nerve ending." [GOC:tfm, ISBN:0517223651] subset: human_subset subset: mouse_subset synonym: "type 1 vestibular hair cell" EXACT [] synonym: "type 1 vestibular sensory cell" EXACT [] synonym: "type I hair cell" EXACT [] xref: FMA:62352 is_a: CL:0000609 ! vestibular hair cell property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-06-29T09:58:19Z [Term] id: CL:0002071 name: enterocyte of epithelium of large intestine def: "A columnar absorptive epithelial cell found in the epithelium of large intestine, specialized for water and electrolyte absorption. Unlike small intestinal enterocytes, those in the large intestine have fewer apical microvilli." [GOC:tfm, ISBN:0517223651, PMID:22288583, PMID:35626748, PMID:38872928] subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "columnar cell" BROAD [] synonym: "columnar cell of the colon" EXACT [] synonym: "vacuolar absorptive cell" EXACT [] xref: BTO:0002484 xref: FMA:63638 xref: FMA:66771 is_a: CL:0000584 ! enterocyte is_a: CL:0002253 {is_inferred="true"} ! epithelial cell of large intestine intersection_of: CL:0000584 ! enterocyte intersection_of: BFO:0000050 UBERON:0001278 ! part of epithelium of large intestine property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/2d-ftu/large-intestine-crypt-lieberkuhn/v1.2/assets/2d-ftu-large-intestine-crypt-lieberkuhn.png" xsd:string {terms:licence="http://creativecommons.org/licenses/by/4.0/", xref="doi:10.48539/HBM294.HJJZ.279"} property_value: RO:0002175 NCBITaxon:9606 property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-06-29T11:07:25Z [Term] id: CL:0002072 name: nodal myocyte def: "A specialized cardiac myocyte in the sinoatrial and atrioventricular nodes. The cell is slender and fusiform confined to the nodal center, circumferentially arranged around the nodal artery." [FMA:67101, GOC:tfm] subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "cardiac pacemaker cell" EXACT [GOC:pr] synonym: "myocytus nodalis" EXACT [] synonym: "P cell" EXACT [] synonym: "pacemaker cell" BROAD [] xref: BTO:0004190 xref: FMA:67101 is_a: CL:0002086 ! specialized cardiac myocyte property_value: RO:0002175 NCBITaxon:9606 property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-06-29T11:41:37Z [Term] id: CL:0002073 name: transitional myocyte def: "Specialized cardiac myocyte which is in the internodal tract and atrioventricular node. The cell is more slender than ordinary atrial myocytes and has more myofibrils than nodal myocytes." [FMA:67142, GOC:tfm] subset: human_subset subset: mouse_subset xref: FMA:67142 is_a: CL:0002086 ! specialized cardiac myocyte property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-06-29T02:39:32Z [Term] id: CL:0002074 name: myocardial endocrine cell def: "The myoendocrine cellis a specialized myocyte localized mainly in the right and left atrial appendages, and also scattered within other areas of the atria and along the conductive system in the ventricular septum. The most conspicuous feature distinguishing myoendocrine cells from other atrial myoctyes is the presence of membane-bounded secretory granules (these granules contain precursor of cardiodilatins or atrial natriuretic polypeptides)." [FMA:67111, GOC:tfm] subset: human_subset subset: mouse_subset xref: FMA:67111 is_a: CL:0000163 ! endocrine cell is_a: CL:0002086 ! specialized cardiac myocyte property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-06-29T11:50:47Z [Term] id: CL:0002075 name: brush cell of tracheobronchial tree def: "A rare type of columnar epithelial cell that is part of the tracheobronchial epithelium. This cell is characterized by a distinctive tuft of apical microvilli, which extends into the cytoplasm, and a pear-shaped morphology, broad at the base and tapering to a narrow apex. It plays vital roles in chemosensation, producing cytokines like IL-25, and enhancing mucociliary clearance through acetylcholine release to support mucus movement and airway defense." [GOC:tfm, ISBN:0517223651, PMID:15817800, PMID:30291131, PMID:37925434] comment: The marker set POU2F3, HOMER3, MYB can identify the Human cell type brush cell of tracheobronchial tree in the lung with a confidence of 0.56 (NS-Forest FBeta value). {xref="https://doi.org/10.5281/zenodo.11165918"} subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "pulmonary brush cell" RELATED [] is_a: CL:0000075 ! columnar/cuboidal epithelial cell is_a: CL:0002202 ! epithelial cell of tracheobronchial tree is_a: CL:0002204 ! tuft cell intersection_of: CL:0002204 ! tuft cell intersection_of: BFO:0000050 UBERON:0008397 ! part of tracheobronchial epithelium relationship: RO:0015004 CLM:1000061 ! has characterizing marker set NS forest marker set of brush cell of tracheobronchial tree (Human lung). property_value: RO:0002175 NCBITaxon:9606 property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0002075" xsd:string {name="brush cell of tracheobronchial tree on CELLxGENE CellGuide"} property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 property_value: terms:description "The brush cell of the tracheobronchial tree is a specialized type of epithelial cell situated in the lung's airways system. Characterized by their visually distinguishable brush-like apical surface, brush cells (also called tuft cells) are given their name due to the tuft of microvilli protruding into the lumen of the respiratory tract. The high electron density and presence of a prominent tubulovesicular system in the apical cytoplasm are other defining microscopic features. \nThe primary function of brush cells is chemosensation within the tracheobronchial system, including the trachea, bronchi and bronchioles. They have been identified as the pulmonary equivalent of taste receptor cells, acting as solitary chemosensory cells that serve as the primary line of defense and alarm signal against hazardous inhaled substances. Brush cells in the tracheobronchial tree express taste receptors and a taste transduction machinery which allow them to detect specific chemical signals from bacteria or environmental toxins and signal a downstream response such as protective reflexes like coughing and increased mucus secretion.\nBrush cells also act as physical barriers to help filtrate and clean the inhaled air, thus making an essential contribution to setting up the so-called mucociliary escalator. The tubulovesicular system within brush cells likely plays a role in transcytosis, which involves the movement of various substances across the epithelial barrier. Overall, the brush or tuft cells form an integral part of the airway's innate immune system, helping maintain a healthy and functional tracheobronchial tree.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1073/pnas.101941810", xref="DOI:10.1164/rccm.200502-203WS", xref="DOI:10.1186/s12931-023-02570-8"} creation_date: 2010-06-29T03:22:46Z [Term] id: CL:0002076 name: endo-epithelial cell def: "An epithelial cell derived from endoderm." [FMA:69075, GOC:tfm] subset: cellxgene_subset subset: human_subset subset: mouse_subset xref: FMA:69075 xref: ZFA:0009383 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: BFO:0000002 is_a: CL:0000066 ! epithelial cell intersection_of: CL:0000066 ! epithelial cell intersection_of: RO:0002202 CL:0000223 ! develops from endodermal cell relationship: RO:0002202 CL:0000223 ! develops from endodermal cell property_value: skos:prefLabel "endo-epithelial cell" xsd:string property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-06-29T03:38:14Z [Term] id: CL:0002077 name: ecto-epithelial cell def: "An epithelial cell derived from ectoderm." [FMA:69074, GOC:tfm] subset: human_subset subset: mouse_subset xref: FMA:69074 xref: ZFA:0009385 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: BFO:0000002 is_a: CL:0000066 ! epithelial cell intersection_of: CL:0000066 ! epithelial cell intersection_of: RO:0002202 CL:0000221 ! develops from ectodermal cell relationship: RO:0002202 CL:0000221 ! develops from ectodermal cell property_value: skos:prefLabel "ecto-epithelial cell" xsd:string property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-06-29T03:38:22Z [Term] id: CL:0002078 name: meso-epithelial cell def: "Epithelial cell derived from mesoderm or mesenchyme." [FMA:69076, GOC:tfm] subset: human_subset subset: mouse_subset synonym: "epithelial mesenchymal cell" EXACT [] xref: FMA:69076 xref: ZFA:0009388 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: BFO:0000002 is_a: CL:0000066 ! epithelial cell intersection_of: CL:0000066 ! epithelial cell intersection_of: RO:0002202 CL:0000222 ! develops from mesodermal cell relationship: RO:0002202 CL:0000222 ! develops from mesodermal cell property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-06-29T03:49:14Z [Term] id: CL:0002079 name: pancreatic ductal cell def: "Epithelial cell found in the ducts of the pancreas. This cell type contributes to the high luminal pH." [FMA:63099, GOC:tfm, PMID:14740223] subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset xref: FMA:63099 xref: ZFA:0009380 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000069 ! branched duct epithelial cell is_a: CL:1001433 ! epithelial cell of exocrine pancreas intersection_of: CL:0000083 ! epithelial cell of pancreas intersection_of: BFO:0000050 UBERON:0001064 ! part of ventral pancreatic duct intersection_of: RO:0002215 GO:0015106 ! capable of bicarbonate transmembrane transporter activity relationship: BFO:0000050 UBERON:0001064 ! part of ventral pancreatic duct relationship: RO:0002215 GO:0015106 ! capable of bicarbonate transmembrane transporter activity property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/2d-ftu/pancreas-intercalated-duct/v1.2/assets/2d-ftu-pancreas-intercalated-duct.png" xsd:string {terms:licence="http://creativecommons.org/licenses/by/4.0/", xref="doi:10.48539/HBM992.RCJX.478"} property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/2d-ftu/pancreas-pancreatic-acinus/v1.2/assets/2d-ftu-pancreas-pancreatic-acinus.png" xsd:string {terms:licence="http://creativecommons.org/licenses/by/4.0/", xref="doi:10.48539/HBM586.MNXV.276"} property_value: RO:0002175 NCBITaxon:9606 property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0002079" xsd:string {name="pancreatic ductal cell on CELLxGENE CellGuide"} property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 property_value: terms:description "Pancreatic ductal cells are a vital structural component of the pancreas, a principal gland involved in digestion and metabolism. These cells exist as flat or cuboidal epithelial cells, primarily organizing themselves to form a network of ducts throughout the pancreas. They create an integral component of the glands' 'exocrine' component, aiding in the transportation of digestive enzymes from the acinar cells (another type of cells in the exocrine pancreas that produce the enzymes) to the small intestine. \nThe primary function of the pancreatic ductal cells revolves around the secretion of bicarbonate ions, contributing to the alkaline pancreatic juice that neutralizes the acidic gastric juice in the duodenum. This action allows for a conducive environment for the activated digestive enzymes to efficiently break down food. Furthermore, the pancreatic ductal cells essentially control the amount of fluid that is released into the duodenum, thereby playing a significant role in maintaining the fluid-electrolyte balance in the body.\nPancreatic ductal cells can also act as the origin point for several pancreatic diseases. The uncontrolled proliferation of these cells often leads to the formation of pancreatic ductal adenocarcinoma, the most common type of pancreatic cancer.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1016/B978-0-12-385233-5.00002-7", xref="DOI:10.1016/j.biocel.2004.07.010", xref="DOI:10.1172/JCI57131", xref="DOI:10.3389/fphys.2011.00036"} creation_date: 2010-06-30T08:49:43Z [Term] id: CL:0002080 name: pancreatic centro-acinar cell def: "A cubodial epithelial cell that is continuous with the lining of intercalated ducts that drain the acinus. This cell type secretes a high pH solution to aid in activation of zymogens, and can differentiate into endocrine and exocrine pancreatic cell types." [GOC:tfm, PMID:12142741, PMID:20018761, PMID:8185160] subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "centroacinar cell of Langerhans" EXACT [] synonym: "pancreatic centroacinar cell" EXACT [] xref: FMA:62455 xref: ZFA:0005740 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:1001433 ! epithelial cell of exocrine pancreas intersection_of: CL:0000083 ! epithelial cell of pancreas intersection_of: BFO:0000050 UBERON:0001263 ! part of pancreatic acinus intersection_of: RO:0002215 GO:0015106 ! capable of bicarbonate transmembrane transporter activity relationship: BFO:0000050 UBERON:0001263 ! part of pancreatic acinus relationship: RO:0002215 GO:0015106 ! capable of bicarbonate transmembrane transporter activity property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/2d-ftu/pancreas-intercalated-duct/v1.2/assets/2d-ftu-pancreas-intercalated-duct.png" xsd:string {terms:licence="http://creativecommons.org/licenses/by/4.0/", xref="doi:10.48539/HBM992.RCJX.478"} property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/2d-ftu/pancreas-pancreatic-acinus/v1.2/assets/2d-ftu-pancreas-pancreatic-acinus.png" xsd:string {terms:licence="http://creativecommons.org/licenses/by/4.0/", xref="doi:10.48539/HBM586.MNXV.276"} property_value: RO:0002175 NCBITaxon:9606 property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-06-30T08:49:52Z [Term] id: CL:0002081 name: type II cell of carotid body def: "This cell resembles a glia cell, express the glial marker S100 and act as a supporting cell to type I cell. This cell is located in a small cluster of type I and type II cells near the fork of the carotid artery." [GOC:tfm, http://en.wikipedia.org/wiki/Carotid_body, PMID:7938227] subset: human_subset subset: mouse_subset synonym: "sheath cell of carotid body" EXACT [] xref: FMA:84187 is_a: CL:0000703 ! sustentacular cell is_a: CL:0002256 ! supporting cell of carotid body property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-06-30T04:23:42Z [Term] id: CL:0002082 name: type II cell of adrenal medulla def: "A chromaffin cell of the adrenal medulla that produces epinephrine." [GOC:tfm] subset: human_subset subset: mouse_subset synonym: "adrenal secreting cell of the adrenal medulla" EXACT [] synonym: "adrenergic chromaffin cell" EXACT [] synonym: "epiniphrine secreting cell of the adrenal medulla" EXACT [] xref: FMA:69322 is_a: CL:0000336 {is_inferred="true"} ! adrenal medulla chromaffin cell is_a: CL:0000454 ! epinephrine secreting cell intersection_of: CL:0000336 ! adrenal medulla chromaffin cell intersection_of: BFO:0000050 UBERON:0001236 ! part of adrenal medulla intersection_of: RO:0002215 GO:0048242 ! capable of epinephrine secretion property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-07-14T09:41:42Z [Term] id: CL:0002083 name: type I cell of adrenal medulla def: "A chromaffin cell of the adrenal medulla that produces norepinephrine." [GOC:tfm, ISBN:068340007X] subset: human_subset subset: mouse_subset synonym: "noradrenergic chromaffin cell" EXACT [] xref: FMA:69321 is_a: CL:0000336 {is_inferred="true"} ! adrenal medulla chromaffin cell is_a: CL:0000459 ! noradrenergic cell intersection_of: CL:0000336 ! adrenal medulla chromaffin cell intersection_of: BFO:0000050 UBERON:0001236 ! part of adrenal medulla intersection_of: RO:0002215 GO:0048243 ! capable of norepinephrine secretion property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-07-14T10:12:24Z [Term] id: CL:0002084 name: Boettcher cell def: "A Boettcher cell is a polyhedral cells on the basilar membrane of the cochlea, and is located beneath Claudius cells. A Boettcher cell is considered a supporting cell for the organ of Corti, and is present only in the lower turn of the cochlea. These cells interweave with each other, and project microvilli into the intercellular space. Because of their structural specialization, a Boettcher cell is believed to play a significant role in the function of the cochlea. They demonstrate high levels of calmodulin, and may be involved in mediating Ca(2+) regulation and ion transport." [GOC:tfm, http://en.wikipedia.org/wiki/Boettcher_cell] subset: human_subset subset: mouse_subset synonym: "Boettcher's cell" EXACT [] synonym: "Bottcher cell" EXACT [] synonym: "Bottcher's cell" EXACT [] is_a: CL:0002315 ! supporting cell of cochlea property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-07-14T03:22:02Z [Term] id: CL:0002085 name: tanycyte alt_id: CL:0000643 def: "A specialized elongated ventricular ependymal cell with one or more processes that extend into the brain parenchyma or associated blood vessels where they contact blood vessel endothelial cells and/or neurons. These cells are found in the ventricles and circumventricular organs of the brain. They are involved in hormonal regulation, gatekeeping molecules between the bloodstream and cerebrospinal fluid, metabolic sensing, and regulating food intake." [GOC:tfm, http://neurolex.org/wiki/Category\:Tanycyte, PMID:29351662] comment: This class includes cells that are sometimes referred to as tanycyte-like cells, located in circumventricular organs (Langlet et al., 2023) as well as tanycytes located in the ventricles. {xref="PMID:23649873"} subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "stretch cell" EXACT [PMID:29351662] synonym: "tanycyte-like cell" NARROW [PMID:23649873] xref: BTO:0001953 xref: FMA:54560 is_a: CL:0000065 ! ependymal cell property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-07-15T11:21:11Z [Term] id: CL:0002086 name: specialized cardiac myocyte def: "A cardiac myocyte that is an excitable cells in the myocardium, specifically in the conducting system of heart." [FMA:67968, GOC:tfm] subset: human_subset subset: mouse_subset xref: FMA:67968 is_a: CL:0000746 ! cardiac muscle cell property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-07-21T01:33:38Z [Term] id: CL:0002087 name: nongranular leukocyte def: "A leukocyte that lacks granules." [GOC:tfm] subset: blood_and_immune_upper_slim subset: human_subset subset: mouse_subset synonym: "agranular leukocyte" EXACT [] xref: FMA:62855 is_a: CL:0000738 {is_inferred="true"} ! leukocyte intersection_of: CL:0000738 ! leukocyte intersection_of: CL:4030045 GO:0030141 ! lacks_part secretory granule relationship: CL:4030045 GO:0030141 ! lacks_part secretory granule property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-07-22T11:30:33Z [Term] id: CL:0002088 name: interstitial cell of Cajal def: "This is a cell found in the gastrointestinal tract of mammals and serves as a pacemaker that triggers gut contraction. ICCs mediate inputs from the enteric nervous system to smooth muscle cells and are thought to be the cells from which gastrointestinal stromal tumors (GISTs) arise." [GOC:tfm, PMID:16460275, PMID:19520112] comment: Some argue this cell type is of mesenchymal origin. subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "ICC" EXACT [] synonym: "intestinal pacemaker cell" EXACT [GOC:pr] xref: BTO:0003914 xref: FMA:86573 is_a: CL:0000710 {is_inferred="true"} ! neurecto-epithelial cell intersection_of: CL:0000710 ! neurecto-epithelial cell intersection_of: RO:0002215 GO:0043134 ! capable of regulation of hindgut contraction relationship: RO:0002215 GO:0043134 ! capable of regulation of hindgut contraction property_value: RO:0002175 NCBITaxon:9606 property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0002088" xsd:string {name="interstitial cell of Cajal on CELLxGENE CellGuide"} property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 property_value: terms:description "Interstitial cells of Cajal are unique cells located in the gastrointestinal tract, specifically within the muscle layers of the entire digestive system. They have a distinctive stellate or spindle-like shape and were named after the Spanish histologist, Ramón y Cajal, who first discovered them.\nThe intricate interplay of interstitial cells of Cajal with smooth muscle cells and enteric neurons orchestrates the rhythmic contractions (known as peristalsis) in the gastrointestinal tract. They generate and propagate the slow waves of electrical activity, providing the fundamental pacing signal. Interstitial cells of Cajal are capable of responding to stretch and other mechanical stimuli, which helps in adapting the frequency and strength of peristalsis as needed. They also play an essential role in relaxations of gastrointestinal tract sphincters, ensuring proper control over the passage of material.\nMoreover, disruption or loss of ICCs contribute to several gastrointestinal motility disorders, underscoring their vital role in digestive health. Lack of or reduced ICCs are reported in various conditions such as achalasia, slow transit constipation, and diabetic gastroparesis.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1016/S0165-6147(97)01108-5", xref="DOI:10.1038/nrgastro.2016.161", xref="DOI:10.1152/ajpgi.00264.2021"} creation_date: 2010-07-22T03:26:00Z [Term] id: CL:0002089 name: group 2 innate lymphoid cell, mouse def: "A group 2 innate lymphoid cell in the mouse capable of secreting IL-13 in response to a helminth infection. This cell is lineage-negative, ICOS-positive, IL1RL1-positive, IL7Ralpha-positive, and IL17Br-positive." [GOC:add, GOC:tfm, PMID:20200518] subset: mouse_subset synonym: "nuocyte" BROAD [] is_a: CL:0001069 ! group 2 innate lymphoid cell intersection_of: CL:0001069 ! group 2 innate lymphoid cell intersection_of: CL:4030046 PR:000001002 ! lacks_plasma_membrane_part CD19 molecule intersection_of: CL:4030046 PR:000001004 ! lacks_plasma_membrane_part CD4 molecule intersection_of: CL:4030046 PR:000001008 ! lacks_plasma_membrane_part integrin alpha-2 intersection_of: CL:4030046 PR:000001012 ! lacks_plasma_membrane_part integrin alpha-M intersection_of: CL:4030046 PR:000001020 ! lacks_plasma_membrane_part CD3 epsilon intersection_of: CL:4030046 PR:000001024 ! lacks_plasma_membrane_part neural cell adhesion molecule 1 intersection_of: CL:4030046 PR:000001084 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD8 alpha chain intersection_of: CL:4030046 PR:000001326 ! lacks_plasma_membrane_part bone marrow stromal antigen 2 intersection_of: CL:4030046 PR:000001893 ! lacks_plasma_membrane_part natural cytotoxicity triggering receptor 1 intersection_of: CL:4030046 PR:000001927 ! lacks_plasma_membrane_part sialic acid-binding Ig-like lectin 5 intersection_of: CL:4030046 PR:000007431 ! lacks_plasma_membrane_part high affinity immunoglobulin epsilon receptor subunit alpha intersection_of: RO:0002104 PR:000001860 ! has plasma membrane part inducible T-cell costimulator intersection_of: RO:0002104 PR:000001869 ! has plasma membrane part interleukin-7 receptor subunit alpha intersection_of: RO:0002104 PR:000008982 ! has plasma membrane part interleukin-17 receptor B intersection_of: RO:0002104 PR:000008994 ! has plasma membrane part interleukin-1 receptor-like 1 intersection_of: RO:0002162 NCBITaxon:10090 ! in taxon Mus musculus intersection_of: RO:0002215 GO:0002830 ! capable of positive regulation of type 2 immune response intersection_of: RO:0002215 GO:0032616 ! capable of interleukin-13 production relationship: CL:4030046 PR:000001004 ! lacks_plasma_membrane_part CD4 molecule relationship: CL:4030046 PR:000001008 ! lacks_plasma_membrane_part integrin alpha-2 relationship: CL:4030046 PR:000001012 ! lacks_plasma_membrane_part integrin alpha-M relationship: CL:4030046 PR:000001024 ! lacks_plasma_membrane_part neural cell adhesion molecule 1 relationship: CL:4030046 PR:000001084 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD8 alpha chain relationship: CL:4030046 PR:000001326 ! lacks_plasma_membrane_part bone marrow stromal antigen 2 relationship: CL:4030046 PR:000001893 ! lacks_plasma_membrane_part natural cytotoxicity triggering receptor 1 relationship: CL:4030046 PR:000001927 ! lacks_plasma_membrane_part sialic acid-binding Ig-like lectin 5 relationship: CL:4030046 PR:000007431 ! lacks_plasma_membrane_part high affinity immunoglobulin epsilon receptor subunit alpha relationship: RO:0002104 PR:000001860 ! has plasma membrane part inducible T-cell costimulator relationship: RO:0002104 PR:000001869 ! has plasma membrane part interleukin-7 receptor subunit alpha relationship: RO:0002104 PR:000008982 ! has plasma membrane part interleukin-17 receptor B relationship: RO:0002104 PR:000008994 ! has plasma membrane part interleukin-1 receptor-like 1 relationship: RO:0002162 NCBITaxon:10090 ! in taxon Mus musculus relationship: RO:0002215 GO:0002830 ! capable of positive regulation of type 2 immune response relationship: RO:0002215 GO:0032616 ! capable of interleukin-13 production property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-08-12T02:22:19Z [Term] id: CL:0002090 name: polar body def: "One of two small cells formed by the first and second meiotic division of oocytes." [GOC:tfm, http://en.wikipedia.org/wiki/Polar_body, ISBN:068340007X] subset: human_subset subset: mouse_subset xref: EHDAA2:0004716 xref: FMA:85543 xref: MESH:D059705 xref: WBbt:0008429 xref: XAO:0000262 is_a: CL:0000021 ! female germ cell property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-08-23T09:49:53Z [Term] id: CL:0002091 name: primary polar body def: "A small cell formed by the first meiotic division of oocytes." [GOC:tfm, ISBN:068340007X] subset: human_subset subset: mouse_subset synonym: "first polar body" EXACT [EHDAA2:0000541] synonym: "polocytus primarius" EXACT [FMA:18650] xref: EHDAA2:0000541 xref: EMAPA:16032 xref: FMA:18650 xref: VHOG:0000464 is_a: CL:0002090 ! polar body property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-08-23T09:49:58Z [Term] id: CL:0002092 name: bone marrow cell def: "A cell found in the bone marrow. This can include fibroblasts, macrophages, adipocytes, osteoblasts, osteoclasts, endothelial cells and hematopoietic cells." [GOC:tfm, ISBN:0618947256] comment: MH consider whether bone marrow cells are bone cells in the structural sense vs. being part of bone organ sense. subset: cellxgene_subset subset: human_subset subset: mouse_subset xref: BTO:0004850 xref: FMA:83621 xref: MESH:D001854 is_a: CL:0001035 {is_inferred="true"} ! bone cell intersection_of: CL:0001035 ! bone cell intersection_of: BFO:0000050 UBERON:0002371 ! part of bone marrow relationship: BFO:0000050 UBERON:0002371 ! part of bone marrow property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-07-22T04:48:15Z [Term] id: CL:0002093 name: secondary polar body def: "A small cell formed by the second meiotic division of oocytes. In mammals, the second polar body may fail to form unless the ovum has been penetrated by a sperm cell." [GOC:tfm, ISBN:068340007X] subset: human_subset subset: mouse_subset synonym: "polocytus secundarius" EXACT [FMA:18651] synonym: "second polar body" EXACT [EHDAA2:0001820] xref: EHDAA2:0001820 xref: EMAPA:16034 xref: EMAPA:16045 xref: FMA:18651 is_a: CL:0002090 ! polar body property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-08-23T09:50:01Z [Term] id: CL:0002094 name: interstitial cell of ovary def: "A cell that makes up the loose connective tissue of the ovary." [GOC:tfm] subset: cellxgene_subset subset: human_subset subset: mouse_subset xref: FMA:18709 is_a: CL:0002132 ! stromal cell of ovary property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-08-23T11:11:34Z [Term] id: CL:0002095 name: hilus cell of ovary def: "A cell in the hilum of the ovary that produces androgens." [GOC:tfm, ISBN:068340007X] subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "hilar cell of ovary" EXACT [] xref: FMA:18710 is_a: CL:0000593 ! androgen secreting cell is_a: CL:0002132 ! stromal cell of ovary property_value: RO:0002175 NCBITaxon:9606 property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-08-23T11:18:18Z [Term] id: CL:0002096 name: internodal tract myocyte def: "A specialised myocyte that lies between the sinoatrial node and the atrioventricular node and is involved in the conduction of electrical signals." [GOC:tfm, ISBN:0781729300] subset: human_subset subset: mouse_subset xref: FMA:223275 is_a: CL:0002086 ! specialized cardiac myocyte is_a: CL:0008009 ! transversely striated visceral muscle cell intersection_of: CL:0000187 ! muscle cell intersection_of: BFO:0000050 UBERON:0009966 ! part of internodal tract relationship: BFO:0000050 UBERON:0009966 ! part of internodal tract property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-08-23T11:24:11Z [Term] id: CL:0002097 name: cortical cell of adrenal gland def: "A cell of the adrenal cortex. Cell types include those that synthesize and secrete chemical derivatives (steroids) of cholesterol." [GOC:tfm] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "adrenal cortex cell" EXACT [] synonym: "adrenocortical cell" EXACT [] xref: FMA:69545 is_a: CL:0000174 ! steroid hormone secreting cell is_a: CL:0002078 {is_inferred="true"} ! meso-epithelial cell is_a: CL:1001601 ! adrenal gland glandular cell intersection_of: CL:0002078 ! meso-epithelial cell intersection_of: BFO:0000050 UBERON:0001235 ! part of adrenal cortex property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0002097" xsd:string {name="cortical cell of adrenal gland on CELLxGENE CellGuide"} property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 property_value: terms:description "Cortical cells of the adrenal gland, or adrenal cortical cells, are essential components of the endocrine system found in the adrenal cortex, the outer region of the adrenal gland. They are responsible for the synthesis and secretion of vital hormones, including glucocorticoids, mineralocorticoids, and small amounts of adrenal androgens. \nThe adrenal cortical cells are further subdivided into three groups based on their position and function: zona glomerulosa, zona fasciculata, and zona reticularis. The zona glomerulosa cells are scattered and primarily secrete mineralocorticoids such as aldosterone; the zona fasciculata contains large adrenal cortical cells replete with liquids (“clear cells”) that release glucocorticoids; and the zona reticularis contains “compact” cells containing lipofuscin that are involved in the secretion of adrenal androgens. Each layer plays a distinct and vital role in maintaining a range of body functions, from metabolic processes to stress response mechanisms.\nThe primary function of these cells corresponds to the hormones they produce. Glucocorticoids, such as cortisol, play a crucial role in glucose metabolism, immune response modulation, and stress response. Mineralocorticoids, primarily aldosterone, actively participate in maintaining the body's electrolyte and water balance by regulating sodium and potassium levels. Meanwhile, adrenal androgens serve as precursors for other sex hormones in both males and females. Therefore, adrenal cortical cells are a central part of the endocrine system, coordinating multiple vital physiological processes.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1016/j.steroids.2009.09.002", xref="DOI:10.1038/s41574-021-00491-4", xref="DOI:10.1152/ajpendo.00100.2011", xref="https://www.ncbi.nlm.nih.gov/books/NBK278945/", xref="https://www.ncbi.nlm.nih.gov/books/NBK537260/"} creation_date: 2010-08-24T01:37:44Z [Term] id: CL:0002098 name: regular cardiac myocyte def: "A cardiac myocyte that is connected to other cardiac myocytes by transverse intercalated discs (GO:0014704) at a regular interval." [GOC:tfm] subset: human_subset subset: mouse_subset synonym: "regular cardiac muscle cell" EXACT [] synonym: "regular cardiac muscle fiber" EXACT [] xref: FMA:67967 is_a: CL:0000746 ! cardiac muscle cell property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0002098" xsd:string {name="regular cardiac myocyte on CELLxGENE CellGuide"} property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 property_value: terms:description "Cardiac myocytes, also known as cardiac muscle cells, form the majority of the cardiac tissue and are responsible for the contractile function of the heart. These myocytes are columnar-shaped cells with centrally located nuclei, and they exhibit visibly striated cytoplasm due to the organized array of myofibrils, which are composed of filaments of actin and myosin. Cardiac myocytes connect with each other through specialized structures called intercalated discs, facilitating electrical and mechanical continuity and enabling synchronous contraction of the heart. They also possess a high number of mitochondria to meet their high energy demand for continuous heartbeat action.\nCardiac myocytes are capable of automaticity, meaning they have the unique ability to spontaneously and rhythmically generate their electrical impulses, a characteristic led by pacemaker cells. The electrical signals initiated and propagated in these cells are responsible for heartbeats. They also respond to the electrical signals transmitted by the autonomic nervous system and chemical signals like hormones. Thus, cardiac myocytes not only participate in maintaining the heart’s function but also play a role in modulating heart rate and strength of contraction in response to the body's changing needs. Consequently, malfunction of these cells leads to serious cardiac diseases such as heart failure and arrhythmias.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.3389/fphys.2013.00102", xref="https://www.ncbi.nlm.nih.gov/books/NBK572070", xref="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3164530", xref="https://www.sciencedirect.com/topics/agricultural-and-biological-sciences/cardiac-muscle"} creation_date: 2010-08-23T11:33:10Z [Term] id: CL:0002099 name: type I cell of adrenal cortex alt_id: CL:1000423 def: "A small, polyhedral, cell found in rounded groups or curved columns with deeply staining nuclei, scanty basophilic cytoplasm and a few lipid droplets. This cell in the zona glomerulosa produces mineralocorticoids." [GOC:tfm, ISBN:0517223651] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "epithelial cell of zona glomerulosa of adrenal gland" EXACT [] xref: FMA:69273 is_a: CL:0000456 ! mineralocorticoid secreting cell is_a: CL:0002097 {is_inferred="true"} ! cortical cell of adrenal gland intersection_of: CL:0002097 ! cortical cell of adrenal gland intersection_of: BFO:0000050 UBERON:0002053 ! part of zona glomerulosa of adrenal gland relationship: BFO:0000050 UBERON:0002053 ! part of zona glomerulosa of adrenal gland property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-08-24T01:42:02Z [Term] id: CL:0002100 name: regular interventricular cardiac myocyte def: "A regular cardiac myocyte of the interventricular region of the heart." [GOC:tfm] subset: human_subset subset: mouse_subset xref: FMA:228792 is_a: CL:0002098 ! regular cardiac myocyte property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-08-23T11:40:52Z [Term] id: CL:0002101 name: CD38-positive naive B cell def: "A CD38-positive naive B cell is a mature B cell that has the phenotype CD38-positive, surface IgD-positive, surface IgM-positive, and CD27-negative, and that has not yet been activated by antigen in the periphery." [GOC:dsd, GOC:rhs, GOC:tfm, PMID:20123131] subset: human_subset subset: mouse_subset synonym: "CD38+ naive B cell" EXACT [] synonym: "CD38+ naive B lymphocyte" EXACT [] synonym: "CD38+ naive B-cell" EXACT [] synonym: "CD38+ naive B-lymphocyte" EXACT [] synonym: "CD38-positive naive B lymphocyte" EXACT [] synonym: "CD38-positive naive B-cell" EXACT [] synonym: "CD38-positive naive B-lymphocyte" EXACT [] is_a: CL:0000788 {is_inferred="true"} ! naive B cell intersection_of: CL:0000788 ! naive B cell intersection_of: RO:0002104 PR:000001408 ! has plasma membrane part ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 relationship: RO:0002104 PR:000001408 ! has plasma membrane part ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 [Term] id: CL:0002102 name: CD38-negative naive B cell def: "A CD38-negative naive B cell is a mature B cell that has the phenotype CD38-negative, surface IgD-positive, surface IgM-positive, and CD27-negative, that has not yet been activated by antigen in the periphery." [GOC:dsd, GOC:rhs, GOC:tfm, PMID:20123131] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "CD38- naive B cell" EXACT [] synonym: "CD38- naive B lymphocyte" EXACT [] synonym: "CD38- naive B-cell" EXACT [] synonym: "CD38- naive B-lymphocyte" EXACT [] synonym: "CD38-negative naive B lymphocyte" EXACT [] synonym: "CD38-negative naive B-cell" EXACT [] synonym: "CD38-negative naive B-lymphocyte" EXACT [] is_a: CL:0000788 {is_inferred="true"} ! naive B cell intersection_of: CL:0000788 ! naive B cell intersection_of: CL:4030046 PR:000001408 ! lacks_plasma_membrane_part ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 relationship: CL:4030046 PR:000001408 ! lacks_plasma_membrane_part ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 [Term] id: CL:0002103 name: IgG-positive double negative memory B cell def: "An IgG-positive double negative memory B cell is a double negative memory B cell with the phenotype IgG-positive, IgD-negative, and CD27-negative." [GOC:dsd, GOC:rhs, GOC:tfm, PMID:20123131] subset: human_subset subset: mouse_subset synonym: "IgG+ dn memory B cell" EXACT [] synonym: "IgG+ dn memory B lymphocyte" EXACT [] synonym: "IgG+ dn memory B-cell" EXACT [] synonym: "IgG+ dn memory B-lymphocyte" EXACT [] synonym: "IgG+ double negative memory B cell" EXACT [] synonym: "IgG+ double negative memory B lymphocyte" EXACT [] synonym: "IgG+ double negative memory B-cell" EXACT [] synonym: "IgG+ double negative memory B-lymphocyte" EXACT [] synonym: "IgG-positive dn memory B cell" EXACT [] synonym: "IgG-positive dn memory B lymphocyte" EXACT [] synonym: "IgG-positive dn memory B-cell" EXACT [] synonym: "IgG-positive dn memory B-lymphocyte" EXACT [] synonym: "IgG-positive double negative memory B lymphocyte" EXACT [] synonym: "IgG-positive double negative memory B-cell" EXACT [] synonym: "IgG-positive double negative memory B-lymphocyte" EXACT [] is_a: CL:0000981 {is_inferred="true"} ! double negative memory B cell intersection_of: CL:0000981 ! double negative memory B cell intersection_of: RO:0002104 GO:0071735 ! has plasma membrane part IgG immunoglobulin complex relationship: RO:0002104 GO:0071735 ! has plasma membrane part IgG immunoglobulin complex [Term] id: CL:0002104 name: IgG-negative double negative memory B cell def: "An IgG-negative double negative memory B cell is a double negative memory B cell with the phenotype IgG-negative, IgD-negative, and CD27-negative." [GOC:dsd, GOC:rhs, GOC:tfm, PMID:20123131] subset: human_subset subset: mouse_subset synonym: "IgG- dn memory B cell" EXACT [] synonym: "IgG- dn memory B lymphocyte" EXACT [] synonym: "IgG- dn memory B-cell" EXACT [] synonym: "IgG- dn memory B-lymphocyte" EXACT [] synonym: "IgG- double negative memory B cell" EXACT [] synonym: "IgG- double negative memory B lymphocyte" EXACT [] synonym: "IgG- double negative memory B-cell" EXACT [] synonym: "IgG- double negative memory B-lymphocyte" EXACT [] synonym: "IgG-negative dn memory B cell" EXACT [] synonym: "IgG-negative dn memory B lymphocyte" EXACT [] synonym: "IgG-negative dn memory B-cell" EXACT [] synonym: "IgG-negative dn memory B-lymphocyte" EXACT [] synonym: "IgG-negative double negative memory B lymphocyte" EXACT [] synonym: "IgG-negative double negative memory B-cell" EXACT [] synonym: "IgG-negative double negative memory B-lymphocyte" EXACT [] is_a: CL:0000981 {is_inferred="true"} ! double negative memory B cell intersection_of: CL:0000981 ! double negative memory B cell intersection_of: CL:4030046 GO:0071735 ! lacks_plasma_membrane_part IgG immunoglobulin complex relationship: CL:4030046 GO:0071735 ! lacks_plasma_membrane_part IgG immunoglobulin complex [Term] id: CL:0002105 name: CD38-positive IgG memory B cell def: "A CD38-positive IgG memory B cell is a class switched memory B cell that expresses IgG on the cell surface with the phenotype CD38-positive and IgG-positive." [GOC:dsd, GOC:rhs, GOC:tfm, PMID:20123131] subset: human_subset subset: mouse_subset synonym: "CD38+ IgG memory B cell" EXACT [] synonym: "CD38+ IgG memory B lymphocyte" EXACT [] synonym: "CD38+ IgG memory B-cell" EXACT [] synonym: "CD38+ IgG memory B-lymphocyte" EXACT [] synonym: "CD38-positive IgG memory B lymphocyte" EXACT [] synonym: "CD38-positive IgG memory B-cell" EXACT [] synonym: "CD38-positive IgG memory B-lymphocyte" EXACT [] is_a: CL:0000979 {is_inferred="true"} ! IgG memory B cell intersection_of: CL:0000979 ! IgG memory B cell intersection_of: RO:0002104 PR:000001408 ! has plasma membrane part ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 relationship: RO:0002104 PR:000001408 ! has plasma membrane part ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 [Term] id: CL:0002106 name: IgD-positive CD38-positive IgG memory B cell def: "An IgD-positive CD38-positive IgG memory B cell is a CD38-positive IgG-positive class switched memory B cell that has class switched and expresses IgD on the cell surface with the phenotype IgD-positive, CD38-positive, and IgG-positive." [GOC:dsd, GOC:rhs, GOC:tfm, PMID:20123131] subset: human_subset subset: mouse_subset is_a: CL:0002105 {is_inferred="true"} ! CD38-positive IgG memory B cell intersection_of: CL:0002105 ! CD38-positive IgG memory B cell intersection_of: RO:0002104 GO:0071738 ! has plasma membrane part IgD immunoglobulin complex relationship: RO:0002104 GO:0071738 ! has plasma membrane part IgD immunoglobulin complex [Term] id: CL:0002107 name: IgD-negative CD38-positive IgG memory B cell def: "An IgD-negative CD38-positive IgG memory B cell is a CD38-positive IgG-positive that has class switched and lacks expression of IgD on the cell surface with the phenotype IgD-negative, CD38-positive, and IgG-positive." [GOC:dsd, GOC:rhs, GOC:tfm, PMID:20123131] subset: human_subset subset: mouse_subset is_a: CL:0002105 {is_inferred="true"} ! CD38-positive IgG memory B cell is_a: CL:4052108 ! IgD-negative class switched memory B cell intersection_of: CL:0002105 ! CD38-positive IgG memory B cell intersection_of: CL:4030046 GO:0071738 ! lacks_plasma_membrane_part IgD immunoglobulin complex [Term] id: CL:0002108 name: CD38-negative IgG memory B cell def: "A CD38-negative IgG memory B cell is a IgG-positive class switched memory B cell that has class switched and expresses IgG on the cell surface with the phenotype CD38-negative, IgD-negative, and IgG-positive." [GOC:dsd, GOC:rhs, GOC:tfm, PMID:20123131] subset: human_subset subset: mouse_subset is_a: CL:0000979 {is_inferred="true"} ! IgG memory B cell is_a: CL:4052108 ! IgD-negative class switched memory B cell intersection_of: CL:0000979 ! IgG memory B cell intersection_of: CL:4030046 GO:0071738 ! lacks_plasma_membrane_part IgD immunoglobulin complex intersection_of: CL:4030046 PR:000001408 ! lacks_plasma_membrane_part ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 relationship: CL:4030046 PR:000001408 ! lacks_plasma_membrane_part ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 [Term] id: CL:0002109 name: B220-positive CD38-positive naive B cell def: "A B220-positive CD38-positive naive B cell is a CD38-positive naive B cell that has the phenotype B220-positive, CD38-positive, surface IgD-positive, surface IgM-positive, and CD27-negative, and that has not yet been activated by antigen in the periphery." [GOC:dsd, GOC:rhs, GOC:tfm, PMID:20123131] subset: human_subset subset: mouse_subset synonym: "B220+CD38+ naive B cell" EXACT [] synonym: "B220+CD38+ naive B lymphocyte" EXACT [] synonym: "B220+CD38+ naive B-cell" EXACT [] synonym: "B220+CD38+ naive B-lymphocyte" EXACT [] synonym: "B220-positive CD38-positive naive B lymphocyte" EXACT [] synonym: "B220-positive CD38-positive naive B-cell" EXACT [] synonym: "B220-positive CD38-positive naive B-lymphocyte" EXACT [] synonym: "CD38+B220+ naive B cell" EXACT [] synonym: "CD38+B220+ naive B lymphocyte" EXACT [] synonym: "CD38+B220+ naive B-cell" EXACT [] synonym: "CD38+B220+ naive B-lymphocyte" EXACT [] is_a: CL:0002101 {is_inferred="true"} ! CD38-positive naive B cell intersection_of: CL:0002101 ! CD38-positive naive B cell intersection_of: RO:0002104 PR:000001014 ! has plasma membrane part receptor-type tyrosine-protein phosphatase C isoform CD45RABC relationship: RO:0002104 PR:000001014 ! has plasma membrane part receptor-type tyrosine-protein phosphatase C isoform CD45RABC [Term] id: CL:0002110 name: B220-low CD38-positive naive B cell def: "A B220-low CD38-positive naive B cell is a CD38-positive naive B cell that has the phenotype B220-low, CD38-positive, surface IgD-positive, surface IgM-positive, and CD27-negative, that has not yet been activated by antigen in the periphery." [GOC:dsd, GOC:rhs, GOC:tfm, PMID:20123131] subset: human_subset subset: mouse_subset is_a: CL:0002109 ! B220-positive CD38-positive naive B cell intersection_of: CL:0002101 ! CD38-positive naive B cell intersection_of: RO:0015016 PR:000001014 ! has low plasma membrane amount receptor-type tyrosine-protein phosphatase C isoform CD45RABC relationship: RO:0015016 PR:000001014 ! has low plasma membrane amount receptor-type tyrosine-protein phosphatase C isoform CD45RABC [Term] id: CL:0002111 name: CD38-negative unswitched memory B cell def: "An CD38-negative unswitched memory B cell is an unswitched memory B cell that has the phenotype CD38-negative, IgD-positive, CD138-negative, and IgG-negative." [GOC:dsd, GOC:rhs, GOC:tfm, PMID:20123131] subset: human_subset subset: mouse_subset synonym: "CD38- unswitched memory B cell" EXACT [] synonym: "CD38- unswitched memory B lymphocyte" EXACT [] synonym: "CD38- unswitched memory B-cell" EXACT [] synonym: "CD38- unswitched memory B-lymphocyte" EXACT [] synonym: "CD38-negative unswitched memory B lymphocyte" EXACT [] synonym: "CD38-negative unswitched memory B-cell" EXACT [] synonym: "CD38-negative unswitched memory B-lymphocyte" EXACT [] is_a: CL:0000970 {is_inferred="true"} ! unswitched memory B cell intersection_of: CL:0000970 ! unswitched memory B cell intersection_of: CL:4030046 PR:000001408 ! lacks_plasma_membrane_part ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 relationship: CL:4030046 PR:000001408 ! lacks_plasma_membrane_part ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 [Term] id: CL:0002112 name: B220-positive CD38-negative unswitched memory B cell def: "A B220-positive CD38-negative unswitched memory B cell is a CD38-negative unswitched memory B cell that has the phenotype B220-positive, CD38-negative, IgD-positive, CD138-negative, and IgG-negative." [GOC:dsd, GOC:rhs, GOC:tfm, PMID:20123131] subset: human_subset subset: mouse_subset is_a: CL:0002111 {is_inferred="true"} ! CD38-negative unswitched memory B cell intersection_of: CL:0002111 ! CD38-negative unswitched memory B cell intersection_of: RO:0002104 PR:000001014 ! has plasma membrane part receptor-type tyrosine-protein phosphatase C isoform CD45RABC relationship: RO:0002104 PR:000001014 ! has plasma membrane part receptor-type tyrosine-protein phosphatase C isoform CD45RABC [Term] id: CL:0002113 name: B220-low CD38-negative unswitched memory B cell def: "A B220-low CD38-negative unswitched memory B cell is a CD38-negative unswitched memory B cell that has the phenotype B220-low, CD38-negative, IgD-positive, CD138-negative, and IgG-negative." [GOC:dsd, GOC:rhs, GOC:tfm, PMID:20123131] subset: human_subset subset: mouse_subset is_a: CL:0002112 ! B220-positive CD38-negative unswitched memory B cell intersection_of: CL:0002111 ! CD38-negative unswitched memory B cell intersection_of: RO:0015016 PR:000001014 ! has low plasma membrane amount receptor-type tyrosine-protein phosphatase C isoform CD45RABC relationship: RO:0015016 PR:000001014 ! has low plasma membrane amount receptor-type tyrosine-protein phosphatase C isoform CD45RABC [Term] id: CL:0002114 name: CD38-positive unswitched memory B cell def: "A CD38-positive unswitched memory B cell is an unswitched memory B cell that has the phenotype CD38-positive, IgD-positive, CD138-negative, and IgG-negative." [GOC:dsd, GOC:rhs, GOC:tfm, PMID:20123131] subset: human_subset subset: mouse_subset synonym: "CD38+ unswitched memory B cell" EXACT [] synonym: "CD38+ unswitched memory B lymphocyte" EXACT [] synonym: "CD38+ unswitched memory B-cell" EXACT [] synonym: "CD38+ unswitched memory B-lymphocyte" EXACT [] synonym: "CD38-positive unswitched memory B lymphocyte" EXACT [] synonym: "CD38-positive unswitched memory B-cell" EXACT [] synonym: "CD38-positive unswitched memory B-lymphocyte" EXACT [] is_a: CL:0000970 {is_inferred="true"} ! unswitched memory B cell intersection_of: CL:0000970 ! unswitched memory B cell intersection_of: RO:0002104 PR:000001408 ! has plasma membrane part ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 relationship: RO:0002104 PR:000001408 ! has plasma membrane part ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 [Term] id: CL:0002115 name: B220-positive CD38-positive unswitched memory B cell def: "A B220-positive CD38-positive unswitched memory B cell is a CD38-positive unswitched memory B cell that has the phenotype B220-positive, CD38-positive, IgD-positive, CD138-negative, and IgG-negative." [GOC:dsd, GOC:rhs, GOC:tfm, PMID:20123131] subset: human_subset subset: mouse_subset is_a: CL:0002114 {is_inferred="true"} ! CD38-positive unswitched memory B cell intersection_of: CL:0002114 ! CD38-positive unswitched memory B cell intersection_of: RO:0002104 PR:000001014 ! has plasma membrane part receptor-type tyrosine-protein phosphatase C isoform CD45RABC relationship: RO:0002104 PR:000001014 ! has plasma membrane part receptor-type tyrosine-protein phosphatase C isoform CD45RABC [Term] id: CL:0002116 name: B220-low CD38-positive unswitched memory B cell def: "A B220-low CD38-positive unswitched memory B cell is a CD38-positive unswitched memory B cell that has the phenotype B220-low, CD38-positive, IgD-positive, CD138-negative, and IgG-negative." [GOC:dsd, GOC:rhs, GOC:tfm, PMID:20123131] subset: human_subset subset: mouse_subset is_a: CL:0002115 ! B220-positive CD38-positive unswitched memory B cell intersection_of: CL:0002114 ! CD38-positive unswitched memory B cell intersection_of: RO:0015016 PR:000001014 ! has low plasma membrane amount receptor-type tyrosine-protein phosphatase C isoform CD45RABC relationship: RO:0015016 PR:000001014 ! has low plasma membrane amount receptor-type tyrosine-protein phosphatase C isoform CD45RABC [Term] id: CL:0002117 name: IgG-negative class switched memory B cell def: "A class switched memory B cell that lacks IgG on the cell surface." [GOC:dsd, GOC:rhs, GOC:tfm, PMID:20123131] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "IgG- class switched memory B cell" EXACT [] synonym: "IgG- class switched memory B lymphocyte" EXACT [] synonym: "IgG- class switched memory B-cell" EXACT [] synonym: "IgG- class switched memory B-lymphocyte" EXACT [] synonym: "IgG-negative class switched memory B lymphocyte" EXACT [] synonym: "IgG-negative class switched memory B-cell" EXACT [] synonym: "IgG-negative class switched memory B-lymphocyte" EXACT [] is_a: CL:4052108 ! IgD-negative class switched memory B cell intersection_of: CL:0000972 ! class switched memory B cell intersection_of: CL:4030046 GO:0071735 ! lacks_plasma_membrane_part IgG immunoglobulin complex relationship: CL:4030046 GO:0071735 ! lacks_plasma_membrane_part IgG immunoglobulin complex [Term] id: CL:0002118 name: CD38-negative IgG-negative class switched memory B cell def: "A CD38-negative IgG-negative memory B cell is a IgG-negative class switched memory B cell that lacks IgG on the cell surface with the phenotype CD38-negative and IgG-negative." [GOC:dsd, GOC:rhs, GOC:tfm, PMID:20123131] subset: human_subset subset: mouse_subset is_a: CL:0002117 {is_inferred="true"} ! IgG-negative class switched memory B cell intersection_of: CL:0002117 ! IgG-negative class switched memory B cell intersection_of: CL:4030046 PR:000001408 ! lacks_plasma_membrane_part ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 relationship: CL:4030046 PR:000001408 ! lacks_plasma_membrane_part ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 [Term] id: CL:0002119 name: CD38-positive IgG-negative class switched memory B cell def: "A CD38-positive IgG-negative memory B cell is an IgG-negative class switched memory B cell that lacks IgG on the cell surface with the phenotype CD38-positive and IgG-negative." [GOC:dsd, GOC:rhs, GOC:tfm, PMID:20123131] subset: human_subset subset: mouse_subset is_a: CL:0002117 {is_inferred="true"} ! IgG-negative class switched memory B cell intersection_of: CL:0002117 ! IgG-negative class switched memory B cell intersection_of: RO:0002104 PR:000001408 ! has plasma membrane part ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 relationship: RO:0002104 PR:000001408 ! has plasma membrane part ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 [Term] id: CL:0002120 name: CD24-positive CD38-negative IgG-negative class switched memory B cell def: "An CD24-positive CD38-negative IgG-negative memory B cell is a CD38-negative IgG-negative class switched memory B cell that lacks IgG on the cell surface with the phenotype CD24-positive, CD38-negative, and IgG-negative." [GOC:dsd, GOC:rhs, GOC:tfm, PMID:20123131] subset: human_subset subset: mouse_subset is_a: CL:0002118 {is_inferred="true"} ! CD38-negative IgG-negative class switched memory B cell intersection_of: CL:0002118 ! CD38-negative IgG-negative class switched memory B cell intersection_of: RO:0002104 PR:000001932 ! has plasma membrane part signal transducer CD24 relationship: RO:0002104 PR:000001932 ! has plasma membrane part signal transducer CD24 [Term] id: CL:0002121 name: CD24-negative CD38-negative IgG-negative class switched memory B cell def: "A CD24-negative CD38-negative IgG-negative memory B cell is a CD38-negative IgG-negative class switched memory B cell that lacks IgG on the cell surface with the phenotype CD24-negative, CD38-negative, and IgG-negative." [GOC:dsd, GOC:rhs, GOC:tfm, PMID:20123131] subset: human_subset subset: mouse_subset is_a: CL:0002118 {is_inferred="true"} ! CD38-negative IgG-negative class switched memory B cell intersection_of: CL:0002118 ! CD38-negative IgG-negative class switched memory B cell intersection_of: CL:4030046 PR:000001932 ! lacks_plasma_membrane_part signal transducer CD24 relationship: CL:4030046 PR:000001932 ! lacks_plasma_membrane_part signal transducer CD24 [Term] id: CL:0002122 name: B220-positive CD38-positive IgG-negative class switched memory B cell def: "A B220-positive CD38-positive IgG-negative memory B cell is a CD38-positive IgG-negative class switched memory B cell that lacks IgG on the cell surface with the phenotype B220-positive, CD38-positive, and IgG-negative." [GOC:dsd, GOC:rhs, GOC:tfm, PMID:20123131] subset: human_subset subset: mouse_subset is_a: CL:0002119 {is_inferred="true"} ! CD38-positive IgG-negative class switched memory B cell intersection_of: CL:0002119 ! CD38-positive IgG-negative class switched memory B cell intersection_of: RO:0002104 PR:000001014 ! has plasma membrane part receptor-type tyrosine-protein phosphatase C isoform CD45RABC relationship: RO:0002104 PR:000001014 ! has plasma membrane part receptor-type tyrosine-protein phosphatase C isoform CD45RABC [Term] id: CL:0002123 name: B220-low CD38-positive IgG-negative class switched memory B cell def: "A B220-low CD38-positive IgG-negative memory B cell is a CD38-positive IgG-negative class switched memory B cell that lacks IgG on the cell surface with the phenotype B220-low, CD38-positive, and IgG-positive." [GOC:dsd, GOC:rhs, GOC:tfm, PMID:20123131] subset: human_subset subset: mouse_subset is_a: CL:0002122 ! B220-positive CD38-positive IgG-negative class switched memory B cell intersection_of: CL:0002119 ! CD38-positive IgG-negative class switched memory B cell intersection_of: RO:0015016 PR:000001014 ! has low plasma membrane amount receptor-type tyrosine-protein phosphatase C isoform CD45RABC relationship: RO:0015016 PR:000001014 ! has low plasma membrane amount receptor-type tyrosine-protein phosphatase C isoform CD45RABC [Term] id: CL:0002124 name: CD27-positive gamma-delta T cell def: "A circulating gamma-delta T cell that is CD27-positive and capable of producing IFN-gamma." [GOC:dsd, GOC:tfm, PMID:19270712] subset: human_subset subset: mouse_subset synonym: "gammadelta27-positive" EXACT [] synonym: "gd27-positive" EXACT [] is_a: CL:0000800 {is_inferred="true"} ! mature gamma-delta T cell intersection_of: CL:0000800 ! mature gamma-delta T cell intersection_of: RO:0002104 PR:000001963 ! has plasma membrane part CD27 molecule intersection_of: RO:0002215 GO:0032609 ! capable of type II interferon production intersection_of: RO:0002353 GO:0030217 ! output of T cell differentiation relationship: RO:0002104 PR:000001963 ! has plasma membrane part CD27 molecule relationship: RO:0002202 CL:0002126 ! develops from CD25-positive, CD27-positive immature gamma-delta T cell relationship: RO:0002215 GO:0032609 ! capable of type II interferon production relationship: RO:0002353 GO:0030217 ! output of T cell differentiation property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-08-18T09:57:19Z [Term] id: CL:0002125 name: CD27-negative gamma-delta T cell def: "A circulating gamma-delta T cell that expresses RORgamma(t), is CD27-negative and is capable of IL-17 secretion." [GOC:dsd, GOC:tfm, PMID:19270712] subset: human_subset subset: mouse_subset synonym: "gammadelta-17 cells" EXACT [PMID:21976777] is_a: CL:0000800 {is_inferred="true"} ! mature gamma-delta T cell intersection_of: CL:0000800 ! mature gamma-delta T cell intersection_of: BFO:0000051 PR:000003455 ! has part nuclear receptor ROR-gamma isoform 2 intersection_of: CL:4030046 PR:000001963 ! lacks_plasma_membrane_part CD27 molecule intersection_of: RO:0002215 GO:0032620 ! capable of interleukin-17 production intersection_of: RO:0002353 GO:0030217 ! output of T cell differentiation relationship: BFO:0000051 PR:000003455 ! has part nuclear receptor ROR-gamma isoform 2 relationship: CL:4030046 PR:000001963 ! lacks_plasma_membrane_part CD27 molecule relationship: RO:0002202 CL:0002126 ! develops from CD25-positive, CD27-positive immature gamma-delta T cell relationship: RO:0002215 GO:0032620 ! capable of interleukin-17 production relationship: RO:0002353 GO:0030217 ! output of T cell differentiation property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-08-18T09:57:29Z [Term] id: CL:0002126 name: CD25-positive, CD27-positive immature gamma-delta T cell def: "A CD25-positive, CD27-positive immature gamma-delta T cell found in the thymus that has an immature phenotype (i.e. CD24-high, CD25-high, CD62L-high, CD44-high, CD2-low, CD5-low)." [GOC:tfm, PMID:19270712] subset: human_subset subset: mouse_subset is_a: CL:0000799 {is_inferred="true"} ! immature gamma-delta T cell is_a: CL:0000893 ! thymocyte intersection_of: CL:0000799 ! immature gamma-delta T cell intersection_of: BFO:0000050 UBERON:0002370 ! part of thymus intersection_of: RO:0002104 PR:000001380 ! has plasma membrane part interleukin-2 receptor subunit alpha intersection_of: RO:0002104 PR:000001919 ! has plasma membrane part programmed cell death protein 1 intersection_of: RO:0002104 PR:000001963 ! has plasma membrane part CD27 molecule intersection_of: RO:0015015 PR:000001307 ! has high plasma membrane amount CD44 molecule intersection_of: RO:0015015 PR:000001318 ! has high plasma membrane amount L-selectin intersection_of: RO:0015015 PR:000001932 ! has high plasma membrane amount signal transducer CD24 intersection_of: RO:0015016 PR:000001083 ! has low plasma membrane amount CD2 molecule intersection_of: RO:0015016 PR:000001839 ! has low plasma membrane amount T-cell surface glycoprotein CD5 relationship: RO:0002104 PR:000001380 ! has plasma membrane part interleukin-2 receptor subunit alpha relationship: RO:0002104 PR:000001919 ! has plasma membrane part programmed cell death protein 1 relationship: RO:0002104 PR:000001963 ! has plasma membrane part CD27 molecule relationship: RO:0015015 PR:000001307 ! has high plasma membrane amount CD44 molecule relationship: RO:0015015 PR:000001318 ! has high plasma membrane amount L-selectin relationship: RO:0015015 PR:000001932 ! has high plasma membrane amount signal transducer CD24 relationship: RO:0015016 PR:000001083 ! has low plasma membrane amount CD2 molecule relationship: RO:0015016 PR:000001839 ! has low plasma membrane amount T-cell surface glycoprotein CD5 property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-08-18T10:35:37Z [Term] id: CL:0002127 name: innate effector T cell def: "A T cell with a receptor of limited diversity that is capable of immediate effector functions upon stimulation." [GOC:tfm, PMID:20581831] subset: human_subset subset: mouse_subset is_a: CL:0000911 {is_inferred="true"} ! effector T cell intersection_of: CL:0000911 ! effector T cell intersection_of: RO:0002215 GO:0045087 ! capable of innate immune response relationship: RO:0002215 GO:0045087 ! capable of innate immune response property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-08-20T02:14:25Z [Term] id: CL:0002128 name: Tc17 cell def: "A CD8-positive, alpha-beta T cell that has the phenotype CXCR3-negative, CCR6-positive, CCR5-high, CD45RA-negative, and capable of producing IL-17 and some IFNg." [GOC:add, GOC:dsd, GOC:tfm, PMID:19201830, PMID:22343568] comment: This cell type is compatible with the HIPC Lyoplate markers for 'Tc17 CD8+ T cell', but its logical definition includes additional known characteristics of Tc17 T cells. Found in the CD27-positive, CD28-positive or CD27-negative, CD28-positive fractions with the phenotype CCR4-negative and CCR7-negative (this sentence not part of definition). subset: human_subset subset: mouse_subset synonym: "CD8-positive Th17 cell" EXACT [] synonym: "Tc17 CD8+ T cell" EXACT [PMID:22343568] synonym: "Tc17 T cell" EXACT [] synonym: "Tc17 T lymphocyte" EXACT [] synonym: "Tc17 T-cell" EXACT [] synonym: "Tc17 T-lymphocyte" EXACT [] synonym: "Th17 CD8-positive T cell" EXACT [] synonym: "Th17 non-TFH CD8-positive T cell" EXACT [] is_a: CL:0000908 {is_inferred="true"} ! CD8-positive, alpha-beta cytokine secreting effector T cell intersection_of: CL:0000908 ! CD8-positive, alpha-beta cytokine secreting effector T cell intersection_of: CL:4030046 PR:000001015 ! lacks_plasma_membrane_part receptor-type tyrosine-protein phosphatase C isoform CD45RA intersection_of: RO:0002104 PR:000001202 ! has plasma membrane part C-C chemokine receptor type 6 intersection_of: RO:0002215 GO:0032620 ! capable of interleukin-17 production intersection_of: RO:0015015 PR:000001201 ! has high plasma membrane amount C-C chemokine receptor type 5 relationship: CL:4030046 PR:000001015 ! lacks_plasma_membrane_part receptor-type tyrosine-protein phosphatase C isoform CD45RA relationship: RO:0002104 PR:000001202 ! has plasma membrane part C-C chemokine receptor type 6 relationship: RO:0002215 GO:0032620 ! capable of interleukin-17 production relationship: RO:0015015 PR:000001201 ! has high plasma membrane amount C-C chemokine receptor type 5 [Term] id: CL:0002129 name: regular atrial cardiac myocyte def: "Regular cardiac myocyte of a cardiac atrium." [GOC:tfm] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "atrial cardiac muscle cell" EXACT [GOC:pr] synonym: "atrial myocyte" EXACT [] synonym: "regular atrial cardiac muscle fiber" EXACT [] synonym: "regular cardiac muscle cell of atrium" EXACT [] xref: FMA:83108 is_a: CL:0002098 ! regular cardiac myocyte property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0002129" xsd:string {name="regular atrial cardiac myocyte on CELLxGENE CellGuide"} property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 property_value: terms:description "Regular atrial cardiac myocytes, also known as atrial myocytes, are specialized muscle cells found in the atria – the upper chambers of the heart. They contract and relax during the heart's cycle, modulating the pumping of blood through the atria and into the ventricles. Additionally, endowed with inherent rhythmic electrical activity, atrial myocytes contribute significantly to the initiation and propagation of the heart’s electrical impulses.\nA distinguishing feature that separates atrial myocytes from other cardiac myocytes is their ability to synthesize and secrete atrial natriuretic peptide (ANP) in response to atrial stretch or dilatation. ANP acts as a potent vasodilator and diuretic, helping to maintain blood pressure and volume homeostasis. The phenomena of atrial stretch or distension, which triggers ANP release, is often in response to excess blood volume entering the heart, providing a mechanism at the cellular level which actively regulates systemic cardiovascular balance.\nLike all cardiac myocytes, atrial myocytes are embedded in a dense network of connective tissue that provides structural support. These cells are characterized by a single, centrally located nucleus, and overall, have a rod-like appearance with branching ends that connect with adjacent cells to form a continuous, synchronized ensemble. Their cytoplasm is abundant with mitochondria, reflecting the high energy demand associated with constant contraction and relaxation. At the ultrastructural level, atrial myocytes display striations due to the regular arrangement of actin and myosin proteins, which facilitate the contraction process essential for the heart's pump function.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1016/j.bbamcr.2015.11.025", xref="DOI:10.1111/pace.14107", xref="DOI:10.1172/JCI25417", xref="https://www.sciencedirect.com/topics/agricultural-and-biological-sciences/cardiac-muscle", xref="https://www.sciencedirect.com/topics/neuroscience/cardiac-action-potential"} creation_date: 2010-08-23T11:41:03Z [Term] id: CL:0002130 name: regular interatrial cardiac myocyte def: "A cardiac myocyte of the interatrial region of the heart." [GOC:tfm] subset: human_subset subset: mouse_subset xref: FMA:228790 is_a: CL:0002098 ! regular cardiac myocyte property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-08-23T11:41:09Z [Term] id: CL:0002131 name: regular ventricular cardiac myocyte def: "Regular cardiac myocyte of a cardiac ventricle." [GOC:tfm] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "regular cardiac muscle cell of ventricle" EXACT [] synonym: "regular ventricular cardiac muscle fiber" EXACT [] synonym: "ventricular cardiac muscle cell" BROAD [GOC:pr] synonym: "ventricular myocyte" EXACT [] xref: FMA:83109 is_a: CL:0002098 ! regular cardiac myocyte property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-08-23T11:41:13Z [Term] id: CL:0002132 name: stromal cell of ovary def: "A stomal cell of the ovary" [GOC:tfm] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "ovarian stromal cell" EXACT [GOC:cjm] xref: FMA:72299 is_a: CL:0000499 ! stromal cell intersection_of: CL:0000499 ! stromal cell intersection_of: BFO:0000050 UBERON:0000992 ! part of ovary relationship: BFO:0000050 UBERON:0000992 ! part of ovary property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0002132" xsd:string {name="stromal cell of ovary on CELLxGENE CellGuide"} property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 property_value: terms:description "Stromal cells of the ovary, also known as ovarian stromal cells, form a significant portion of the ovarian tissue. They are non-epithelial cells that primarily make up the supportive or connective tissue—similar to the stroma of other organs—in the ovaries. These cells play vital roles in folliculogenesis, including in the activation of primordial follicles and in the differentiation of theca cells. They are crucial for maintaining the structure, function, and overall health of the ovaries. In addition to roles in hormone production and follicle maturation, stromal cells of the ovary play a role in ovarian aging and age-related diseases such as ovarian cancer. They participate in cell-to-cell communication with oocyte and other ovarian cell types through gap junctions and paracrine signaling and help maintain the ovarian microenvironment.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1017/CBO9780511921896.037", xref="DOI:10.1038/s42003-022-04384-8", xref="DOI:10.1186/s13578-017-0163-5", xref="DOI:10.1371/journal.pone.0205494", xref="DOI:10.1530/REP-19-0501"} creation_date: 2010-08-23T12:10:31Z [Term] id: CL:0002133 name: stromal cell of ovarian cortex def: "A stromal cell of the ovarian cortex." [GOC:tfm] subset: human_subset subset: mouse_subset xref: FMA:256169 is_a: CL:0002132 ! stromal cell of ovary property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-08-23T12:12:15Z [Term] id: CL:0002134 name: stromal cell of ovarian medulla def: "A stromal cell of the ovarian medulla." [GOC:tfm] subset: human_subset subset: mouse_subset xref: FMA:256171 is_a: CL:0002132 {is_inferred="true"} ! stromal cell of ovary intersection_of: CL:0000499 ! stromal cell intersection_of: BFO:0000050 UBERON:0013192 ! part of ovarian medulla relationship: BFO:0000050 UBERON:0013192 ! part of ovarian medulla property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-08-23T12:12:17Z [Term] id: CL:0002135 name: nonkeratinized cell of epidermis def: "Epidermal cells that do not contain keratin. Cell type is usually associated with moist epidermal tissues." [GO:tfm, PMID:1987287] subset: human_subset subset: mouse_subset xref: FMA:62880 is_a: CL:0000362 ! epidermal cell relationship: BFO:0000050 UBERON:0001003 ! part of skin epidermis property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-08-24T08:43:27Z [Term] id: CL:0002136 name: type II cell of adrenal cortex def: "A cell in the zona fasciculata that produce glucocorticoids, e.g cortisol." [GOC:tfm, ISBN:0517223651] subset: human_subset subset: mouse_subset synonym: "type II cortical cell of adrenal gland" EXACT [] xref: FMA:69547 is_a: CL:0000460 ! glucocorticoid secreting cell is_a: CL:0002097 ! cortical cell of adrenal gland property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-08-24T01:50:42Z [Term] id: CL:0002137 name: type III cell of adrenal cortex def: "A cell in the zona reticularis that produce sex hormones." [GOC:tfm, ISBN:0517223651] subset: human_subset subset: mouse_subset xref: FMA:69564 is_a: CL:0000593 ! androgen secreting cell is_a: CL:0002097 ! cortical cell of adrenal gland property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-08-24T01:50:44Z [Term] id: CL:0002138 name: endothelial cell of lymphatic vessel alt_id: CL:1000421 def: "A endothelial cell of a lymphatic vessel. The border of the oak leaf-shaped endothelial cell of initial lymphatics are joined by specialized buttons. The discontinuous feature of buttons distinguishes them from zippers in collecting lymphatics, but both types of junctions are composed of proteins typical of adherens junctions and tight junctions found in the endothelium of blood vessels. Buttons seal the sides of flaps of the oak leaf-shaped endothelial cell, leaving open the tips of flaps as routes for fluid entry without disassembly and reformation of intercellular junctions." [GOC:tfm, PMID:17846148] subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "LEC" EXACT [] synonym: "lymphatic endothelial cell" EXACT [] xref: BTO:0004167 xref: FMA:68458 is_a: CL:0002139 {is_inferred="true"} ! endothelial cell of vascular tree intersection_of: CL:0000115 ! endothelial cell intersection_of: BFO:0000050 UBERON:0001473 ! part of lymphatic vessel relationship: BFO:0000050 UBERON:0001473 ! part of lymphatic vessel relationship: RO:0002202 CL:0005022 ! develops from vascular lymphangioblast property_value: RO:0002175 NCBITaxon:9606 property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0002138" xsd:string {name="endothelial cell of lymphatic vessel on CELLxGENE CellGuide"} property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 property_value: terms:description "Endothelial cells of lymphatic vessels are specialized type of cells that form the interior lining of the lymphatic system, which primarily comprises the lymph vessels and nodes. These cells play a critical role in creating a barrier between the lymphatic system and the surrounding tissues. They are structurally different from the endothelial cells of the blood vessels due to the presence of anchoring filaments and lack of a continuous basement membrane, and have a unique phenotype marked by the expression of various cell-specific markers such as Prox-1, VEGFR-3, and LYVE-1.\nA significant function of these endothelial cells is to maintain the fluid balance within the body. They facilitate the uptake of excess interstitial fluid that collects in the body tissues, and ensure its transport back into the bloodstream via the lymphatic vessels. These cells also enable the absorption of fats and fat-soluble vitamins from the digestive system, and their subsequent transport in the form of chyle, a milky fluid, to the blood.\nFurthermore, endothelial cells of lymphatic vessels play a pivotal role in the body's immune response. They enable the passage of lymphocytes, that are crucial for the body's defense mechanism, from the tissues into the lymph where these cells are activated to fight against foreign bodies and infections. Also, they regulate inflammation reactions by controlling the migration of inflammatory cells, and are thus involved in pathological conditions with an inflammatory component. Lastly, these cells have been noted for their involvement in various disease states related to tissue edema, metastasis, and tumor growth, thus highlighting their importance in both health and disease states.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1016/j.it.2022.10.010", xref="DOI:10.1038/s41577-020-0281-x", xref="DOI:10.3389/fimmu.2019.00036", xref="DOI:10.3389/fphys.2020.00509/full", xref="DOI:10.3892/mco.2017.1356"} creation_date: 2010-08-24T02:05:28Z [Term] id: CL:0002139 name: endothelial cell of vascular tree def: "An endothelial cell of the vascular tree, which includes blood vessels and lymphatic vessels." [GOC:dsd, GOC:tfm, PMID:12768659] comment: These cells are reportedly CD31-positive, CD34-positive, CD144-positive, TAL1-positive. subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "cubodial endothelial cell of vascular tree" NARROW [] synonym: "vascular endothelial cell" EXACT [] xref: BTO:0001854 xref: CALOHA:TS-1106 xref: FMA:67755 is_a: CL:0000115 ! endothelial cell property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0002139" xsd:string {name="endothelial cell of vascular tree on CELLxGENE CellGuide"} property_value: skos:prefLabel "endothelial cell of vascular tree" xsd:string property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 property_value: terms:description "Endothelial cells of the vascular tree, commonly referred to as vascular endothelial cells, line the entire circulatory system, from the heart to the smallest capillaries. These cells have a unique, flattened shape, and are tightly bound together, forming a thin layer known as the endothelium. The endothelium is responsible for maintaining the interior surface of blood vessels, and plays a critical role in ensuring the smooth flow of blood. \nVascular endothelial cells act as a semi-permeable membrane, controlling the passage of materials and the transit of white blood cells into and out of the bloodstream. These cells are also involved in blood coagulation. When a blood vessel is damaged, endothelial cells promote clotting to prevent excessive bleeding and facilitate wound healing. Other functions include regulation of blood pressure and blood volume by releasing vasodilators and vasoconstrictors to either widen or constrict blood vessels, accordingly.\nFurthermore, the endothelial cells are crucial in the formation of new blood vessels, a process known as angiogenesis. This is particularly important in wound healing and the growth of new tissues during development or after injury. In the context of diseases such as cancer, angiogenesis helps facilitate tumor growth by providing nutrients and oxygen.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1038/s41569-022-00770-1", xref="DOI:10.1186/s12872-015-0124-z", xref="DOI:10.3389/fphys.2022.863265/full", xref="https://www.sciencedirect.com/topics/medicine-and-dentistry/vascular-endothelial-cell"} creation_date: 2010-08-24T02:06:40Z [Term] id: CL:0002140 name: skin sebocyte alt_id: CL:0002587 def: "An acinar cell that is part of a skin sebaceous gland. This cell produces and secretes sebum into hair follicles." [GOC:tfm, PMID:37205445] subset: human_subset subset: mouse_subset synonym: "acinar cell of sebaceous gland" BROAD [] synonym: "acinar cell of skin sebaceous gland" EXACT [] xref: BTO:0004613 xref: FMA:70953 is_a: CL:0000317 {is_inferred="true"} ! sebocyte is_a: CL:0000622 ! acinar cell intersection_of: CL:0000622 ! acinar cell intersection_of: BFO:0000050 UBERON:0003487 ! part of skin sebaceous gland relationship: BFO:0000050 UBERON:0003487 ! part of skin sebaceous gland property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-08-24T09:27:52Z [Term] id: CL:0002141 name: active chief cell of parathyroid gland def: "A parathyroid chief cell that is actively secreting hormone. Have large Golgi complexes with numerous vesicles and small membrane-bound granules; secretory granules are rare, cytoplasmic glycogen sparse, much of the cytoplasm being occupied by flat sacs of granular endoplasmic reticulum in parallel arrays; in normal humans, inactive chief cells outnumber active chief cells in a ratio of 3-5:1" [FMA:0517223651, GOC:tfm] subset: human_subset subset: mouse_subset xref: FMA:69082 is_a: CL:0000446 ! chief cell of parathyroid gland property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-08-24T09:30:15Z [Term] id: CL:0002142 name: dark cell of eccrine sweat gland def: "A cell pyramidal in shape, with their broad ends facing and forming the greater extent of the lining of the main lumen. Secretes glycoproteins associated with mucus." [ISBN:0517223651] subset: human_subset subset: mouse_subset xref: FMA:70659 is_a: CL:0000152 ! exocrine cell is_a: CL:0000318 ! sweat secreting cell is_a: CL:0000434 ! eccrine cell is_a: CL:1000448 ! epithelial cell of sweat gland relationship: BFO:0000050 UBERON:0000423 ! part of eccrine sweat gland property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-08-24T02:15:16Z [Term] id: CL:0002143 name: dark chief cell of parathyroid gland def: "A chief cell that is smaller than light chief cells and has a smaller and darker nucleus and a finely granular cytoplasm with many granules." [GOC:tfm, ISBN:0721662544] subset: human_subset subset: mouse_subset xref: FMA:69080 is_a: CL:0000446 ! chief cell of parathyroid gland property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-08-24T02:18:36Z [Term] id: CL:0002144 name: capillary endothelial cell def: "An endothelial cell found in capillaries." [GOC:tfm] subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset xref: BTO:0004956 xref: CALOHA:TS-0112 xref: FMA:67756 is_a: CL:0002653 ! squamous endothelial cell is_a: CL:2000008 ! microvascular endothelial cell intersection_of: CL:0000071 ! blood vessel endothelial cell intersection_of: BFO:0000050 UBERON:0001915 ! part of endothelium of capillary relationship: BFO:0000050 UBERON:0001915 ! part of endothelium of capillary property_value: RO:0002175 NCBITaxon:9606 property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0002144" xsd:string {name="capillary endothelial cell on CELLxGENE CellGuide"} property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 property_value: terms:description "Capillary endothelial cells are particularly essential in the formation and function of capillaries - the smallest and most widespread blood vessels in the body. They play two primary roles: barrier function and transport function. Acting as barriers, they strictly control the passage of nutrients, gases, biological molecules, and cells between the blood and the surrounding tissues. This function not only provides a protective shield to internal organs against potentially harmful substances but also regulates the fluid and solute exchange. In terms of transport, these cells facilitate the diffusion of oxygen and essential nutrients from the bloodstream into the tissues. Concurrently, they allow waste products like carbon dioxide to pass from tissues into the bloodstream for removal, making these cells exceptionally instrumental in maintaining the body’s homeostasis.\nMoreover, capillary endothelial cells are also actively involved in numerous other physiological processes such as inflammation, blood clotting, and angiogenesis. During inflammation, they can specifically express and secrete molecules to attract white blood cells to sites of damage. Similarly, in blood clotting, they produce substances that prevent blood cells from sticking to the vessel wall and deter the formation of unnecessary clots. In angiogenesis, they proliferate and organize the formation of new blood vessels, crucial for wound healing and embryonic development. The disruption of their function contributes to pathological conditions like edema, thrombosis, and several cardiovascular diseases.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1097/01.CCM.0000057847.32590.C1", xref="DOI:10.1152/ajpheart.00704.2007", xref="DOI:10.3390/ijms20184411"} creation_date: 2010-08-24T10:15:00Z [Term] id: CL:0002145 name: multiciliated columnar cell of tracheobronchial tree def: "A multi-ciliated epithelial cell located in the trachea and bronchi, characterized by a columnar shape and motile cilia on its apical surface. These cilia facilitate mucociliary clearance by moving mucus and trapped particles toward the pharynx." [GOC:tfm, PMID:28400610] comment: The marker set C1orf194, MS4A8 can identify the Human cell type multiciliated columnar cell of tracheobronchial tree in the lung with a confidence of 0.86 (NS-Forest FBeta value). These cells possess numerous cilia on their surface, typically ranging from 200 to 300 per cell. The cilia vary in length, measuring between 6 to 7 μm in the upper airways (trachea) and becoming shorter, around 4 μm, in the smaller airways (terminal bronchioles). These cells form a two-layered 'coat' in the airway: the lower 'sol' layer is watery, allowing the cilia to beat in coordinated waves, while the upper 'gel' layer is thick and sticky, trapping inhaled particles. {xref="https://doi.org/10.5281/zenodo.11165918", xref="PMID:25386990", xref="https://doi.org/10.1016/B978-032304048-8.50071-2"} subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "ciliated columnar cell of tracheobronchial tree" EXACT [] xref: FMA:70542 is_a: CL:0002202 ! epithelial cell of tracheobronchial tree is_a: CL:4030034 ! respiratory tract multiciliated cell intersection_of: CL:0000075 ! columnar/cuboidal epithelial cell intersection_of: BFO:0000050 UBERON:0008397 ! part of tracheobronchial epithelium intersection_of: BFO:0000051 GO:0031514 ! has part motile cilium intersection_of: RO:0000053 PATO:0010007 ! has characteristic multiciliated relationship: RO:0002202 CL:0002209 ! develops from intermediate epitheliocyte relationship: RO:0015004 CLM:1000041 ! has characterizing marker set NS forest marker set of multiciliated columnar cell of tracheobronchial tree (Human lung). property_value: RO:0002175 NCBITaxon:9606 property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0002145" xsd:string {name="multiciliated columnar cell of tracheobronchial tree on CELLxGENE CellGuide"} property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 property_value: terms:description "Ciliated columnar cells of the tracheobronchial tree compose the inner lining of the tracheobronchial tree, the system of airways consisting of trachea, bronchi and bronchioles that allow passage of air into the lungs, where gas exchange occurs. A defining feature of these endo-epithelial cells are the tiny hair-like structures covering their surface, known as cilia. The nucleus is located at the base of the cell, and the area above it is rich in mitochondria and well-developed endoplasmic reticulum, both crucial for the energy-intensive process of cilia operation.\nThe primary function of these ciliated cells is to keep the respiratory tract clean via mucociliary clearance or the respiratory escalator. These cells create a two-layered 'coat': The lower \"sol\" layer is watery where the cilia can beat in coordinated waves, and the upper \"gel\" layer is thick and sticky, trapping inhaled particles, such as dust, bacteria, viruses, and other potentially harmful substances. This rhythmical beating of the cilia then moves the mucus and trapped particles upwards and out of the respiratory tract, which is then either coughed out or swallowed.\nDamage or dysfunction of these ciliated cells, as seen in diseases such as primary ciliary dyskinesia, cystic fibrosis, or chronic bronchitis, may lead to reduced or ineffective mucociliary clearance and an increased susceptibility to respiratory infections.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1101/cshperspect.a028241", xref="DOI:10.1146/annurev-physiol-021014-071931", xref="DOI:10.1152/ajplung.00329.2019", xref="DOI:10.1159/000196486"} creation_date: 2010-08-24T03:38:29Z [Term] id: CL:0002146 name: clear cell of eccrine sweat gland def: "A sweat producing cell of eccrine sweat glands. Pyramidal in shape, with its base resting on the basal lamina or myoepitheliocytes, and its microvillus-covered apical plasma membrane line up the intercellular canaliculi. Cell is not stained by hematoxylin or eosin." [GOC:tfm, ISBN:0517223651] subset: human_subset subset: mouse_subset xref: FMA:70658 is_a: CL:0000152 ! exocrine cell is_a: CL:0000318 ! sweat secreting cell is_a: CL:0000434 ! eccrine cell is_a: CL:1000448 ! epithelial cell of sweat gland relationship: BFO:0000050 UBERON:0000423 ! part of eccrine sweat gland property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-08-24T10:33:02Z [Term] id: CL:0002147 name: clear chief cell of parathyroid gland def: "A chief cell of parathyroid glands that does not stain with hematoxylin or eosin. This cell is larger, has a larger nucleus and fewer secretory granules than dark chief cells." [GOC:tfm, ISBN:0618947256] subset: human_subset subset: mouse_subset synonym: "clear chief cell of parathyroid cell" EXACT [] xref: FMA:69081 is_a: CL:0000446 ! chief cell of parathyroid gland property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-08-24T10:39:42Z [Term] id: CL:0002148 name: dental pulp cell def: "A cell found within the dental pulp." [GOC:tfm, PMID:36267574] subset: human_subset subset: mouse_subset xref: CALOHA:TS-0195 xref: FMA:87170 is_a: CL:0002159 ! general ecto-epithelial cell is_a: CL:0002320 ! connective tissue cell intersection_of: CL:0002159 ! general ecto-epithelial cell intersection_of: BFO:0000050 UBERON:0001754 ! part of dental pulp relationship: BFO:0000050 UBERON:0001754 ! part of dental pulp property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-08-24T02:52:09Z [Term] id: CL:0002149 name: epithelial cell of uterus alt_id: CL:1000294 def: "An epithelial cell of the uterus. This cell has a mesodermal origin." [GOC:tfm, PMID:11331626, PMID:16960017, PMID:21698266] subset: cellxgene_subset subset: human_subset subset: mouse_subset xref: FMA:256161 is_a: CL:0002078 ! meso-epithelial cell intersection_of: CL:0000066 ! epithelial cell intersection_of: BFO:0000050 UBERON:0006955 ! part of uterine epithelium relationship: BFO:0000050 UBERON:0006955 ! part of uterine epithelium property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-08-24T10:45:54Z [Term] id: CL:0002150 name: epithelioid macrophage def: "Epithelioid macrophage is an activated macrophage that resembles an epithelial cell with finely granular, pale eosinophilic cytoplasm and central, ovoid nucleus (oval or elongate). This cell type is able to merge into one another to form aggregates. The presence of such aggregates may characterize some pathologic conditions, mainly granulomatous inflammation." [MESH:D015622, PMID:12673090] subset: human_subset subset: mouse_subset synonym: "epithelioid cell" BROAD [] synonym: "epithelioid histocyte" EXACT [MESH:D015622, PMID:12673090] synonym: "epitheloid macrophage" EXACT [] xref: FMA:83514 is_a: CL:0000235 ! macrophage relationship: RO:0002202 CL:0000861 ! develops from elicited macrophage property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-08-24T03:48:30Z [Term] id: CL:0002151 name: late promyelocyte def: "A promyelocyte that is considerably smaller, with more condensed chromatin, and nucleoli are no longer conspicuous." [ISBN:0412046911] subset: cellxgene_subset subset: human_subset subset: mouse_subset xref: FMA:83534 is_a: CL:0000836 ! promyelocyte property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-08-24T03:07:50Z [Term] id: CL:0002152 name: columnar cell of endocervix def: "A simple columnar epithelial cell located in the endocervix." [doi:/10.1016/j.autneu.2015.04.008, GOC:tfm, ISBN:0721662544] subset: human_subset subset: mouse_subset xref: FMA:86486 is_a: CL:0000146 ! simple columnar epithelial cell is_a: CL:0002535 ! epithelial cell of cervix intersection_of: CL:0000146 ! simple columnar epithelial cell intersection_of: BFO:0000050 UBERON:0012252 ! part of endocervical epithelium relationship: BFO:0000050 UBERON:0012252 ! part of endocervical epithelium property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-08-24T10:47:47Z [Term] id: CL:0002153 name: corneocyte def: "The dead keratin-filled squamous cell of the stratum corneum. This cell type lacks a nucleus." [GOC:tfm, ISBN:068340007X] subset: human_reference_atlas subset: human_subset subset: mouse_subset xref: BTO:0001943 xref: FMA:68650 is_a: BFO:0000002 is_a: CL:0000225 ! anucleate cell is_a: CL:0000255 ! eukaryotic cell is_a: CL:0000311 ! keratin accumulating cell relationship: BFO:0000050 UBERON:0002027 ! part of stratum corneum of epidermis relationship: RO:0002202 CL:0000312 ! develops from keratinocyte property_value: RO:0002175 NCBITaxon:9606 property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-08-24T10:53:03Z [Term] id: CL:0002154 name: early promyelocyte def: "A promyelocyte with a nucleus that is indented and contains more marginated heterochromatin compared to its precursor cell (myeloblast); cytoplasm is deeply basophilic and contains numerous mitochondria and meandering cysternae of endoplasmic reticulum; largest of the granulocyte lineages." [FMA:0412046911, GOC:tfm] subset: cellxgene_subset subset: human_subset subset: mouse_subset xref: FMA:83533 is_a: CL:0000836 ! promyelocyte property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-08-24T03:07:53Z [Term] id: CL:0002155 name: echinocyte def: "A crenated erythrocyte with 30+ crenations, bumps or spurs that are the result of damage due to age or disease." [GOC:tfm] subset: human_subset subset: mouse_subset synonym: "burr cell" EXACT [] xref: FMA:81099 is_a: CL:0000595 ! enucleate erythrocyte property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-08-24T03:15:21Z [Term] id: CL:0002157 name: endosteal cell def: "A cell type that makes up the highly vascular membrane lining the marrow cavity of long bones." [FMA:0618947256, GOC:tfm] subset: cellxgene_subset subset: human_subset subset: mouse_subset xref: FMA:86495 is_a: CL:0001035 ! bone cell is_a: CL:0002078 ! meso-epithelial cell relationship: BFO:0000050 UBERON:0009859 ! part of endosteum property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0002157" xsd:string {name="endosteal cell on CELLxGENE CellGuide"} property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 property_value: terms:description "Endosteal cells, also known as osteogenic cells, are a specialized type of cell that resides in the endosteum of the bone marrow cavity. The endosteum is a thin vascular membrane of connective tissue that lines the inner surface of the bony tissue that forms the medullary cavity of long bones. This specific location assigns endosteal cells critical roles in the bone maintenance and regeneration process as they actively participate in bone remodeling, a process that involves both the formation and resorption of bone tissue.\nEndosteal cells function by regulating the activity of both osteoblasts and osteoclasts. Osteoblasts are cells that deposit new bone, and osteoclasts are responsible for bone resorption, a process important for the maintenance, repair, and remodelling of bones. When new bone tissue is required, such as in instances of bone fractures or increased mechanical stress, endosteal cells differentiate into osteoblasts to facilitate the bone formation process. Conversely, when bone resorption is necessary, these cells are known to release signals that lead to the recruitment and activation of osteoclasts.\nIn addition to this, endosteal cells play a significant role in hematopoiesis, which is the formation of blood cellular components. They function in this process by providing a niche for hematopoietic stem cells, serving to support their maintenance and differentiation. Understanding the functionality of endosteal cells is important in the field of regenerative medicine and stem cell therapy, especially in diseases affecting bone remodeling and hematopoiesis.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1038/leu.2010.214", xref="DOI:10.1126/science.75570", xref="DOI:10.1182/blood-2004-06-2480", xref="DOI:10.1182/blood-2009-08-239194", xref="https://www.sciencedirect.com/topics/engineering/endosteum"} creation_date: 2010-08-24T03:33:58Z [Term] id: CL:0002158 name: external epithelial cell of tympanic membrane def: "Epithelial cell found on the external side of the tympanic membrane" [GOC:tfm, PMID:5686391] subset: human_subset subset: mouse_subset xref: FMA:70558 is_a: CL:0002159 ! general ecto-epithelial cell property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-08-25T10:25:31Z [Term] id: CL:0002159 name: general ecto-epithelial cell def: "Epithelial cells derived from general body ectoderm and ectoderm placodes." [GOC:tfm] subset: human_subset subset: mouse_subset xref: FMA:70556 is_a: CL:0002077 ! ecto-epithelial cell property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-08-26T08:31:08Z [Term] id: CL:0002160 name: basal external epithelial cell of tympanic membrane def: "A cell type found in the basal epithelial layer on the external side of the tympanic membrane. Cell type is flattened with intracellular spaces of variable dimensions." [PMID:5686391] subset: human_subset subset: mouse_subset is_a: CL:0002158 ! external epithelial cell of tympanic membrane property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-08-25T10:28:44Z [Term] id: CL:0002161 name: superficial external epithelial cell of tympanic membrane def: "A cell type found on the superficial layer of the external side of the tympanic membrane. This cell-type lacks a nucleus." [PMID:5686391] subset: human_subset subset: mouse_subset is_a: CL:0002158 ! external epithelial cell of tympanic membrane property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-08-25T10:28:48Z [Term] id: CL:0002162 name: internal epithelial cell of tympanic membrane def: "An extremely flattened cell type found on the inner side of the tympanic membrane. The surface of this cell type carries sparse pleomorphic microvilli that are more common near the junctional zones." [FMA:5686391, GOC:tfm] subset: human_subset subset: mouse_subset xref: FMA:70626 is_a: CL:0002076 ! endo-epithelial cell relationship: BFO:0000050 UBERON:0002364 ! part of tympanic membrane property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-08-25T10:49:46Z [Term] id: CL:0002163 name: internal pillar cell of cochlea def: "A rod-shpaed cell that forms a single row adjacent to and supporting the inner hair cells." [GOC:tfm, http://www.theodora.com/anatomy/the_internal_ear_or_labyrinth.html] subset: human_subset subset: mouse_subset xref: FMA:75726 is_a: CL:1000191 ! pillar cell property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-08-25T11:05:21Z [Term] id: CL:0002164 name: external pillar cell of cochlea def: "A rod-shaped cell found in 3 or 4 rows that lie adjacent to and support the outer hair cells." [GOC:tfm, http://www.theodora.com/anatomy/the_internal_ear_or_labyrinth.html] subset: human_subset subset: mouse_subset xref: FMA:75727 is_a: CL:1000191 ! pillar cell property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-08-25T11:05:23Z [Term] id: CL:0002165 name: phalangeal cell def: "A supporting cell that is attached to the basement membrane and forms rows that support the hair cells." [GOC:tfm, ISBN:0618947256] subset: human_subset subset: mouse_subset xref: FMA:79800 is_a: CL:0002490 ! organ of Corti supporting cell property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-08-25T01:29:07Z [Term] id: CL:0002166 name: epithelial cell of Malassez def: "An epithelial cell that remains from the disintegration of the epithelial root sheath involved in the development of teeth." [GOC:tfm, ISBN:0517223651, ISBN:0815129521] subset: human_subset subset: mouse_subset synonym: "epithelial cell rests of Malassez" EXACT [] synonym: "epithelial debris of Malassez" EXACT [] xref: FMA:62987 is_a: CL:0002159 {is_inferred="true"} ! general ecto-epithelial cell relationship: BFO:0000050 UBERON:0011595 ! part of jaw region property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-08-26T08:51:27Z [Term] id: CL:0002167 name: olfactory epithelial cell def: "A specialized cell involved in sensory perception of smell." [GOC:tfm, PMID:7143026] subset: cellxgene_subset subset: human_subset subset: mouse_subset xref: FMA:67870 is_a: CL:0000098 ! sensory epithelial cell is_a: CL:0000206 ! chemoreceptor cell is_a: CL:0000710 ! neurecto-epithelial cell is_a: CL:0002319 ! neural cell is_a: CL:0002631 ! epithelial cell of upper respiratory tract intersection_of: CL:0000066 ! epithelial cell intersection_of: BFO:0000050 UBERON:0001997 ! part of olfactory epithelium relationship: BFO:0000050 UBERON:0001997 ! part of olfactory epithelium relationship: RO:0002215 GO:0050911 ! capable of detection of chemical stimulus involved in sensory perception of smell property_value: skos:prefLabel "olfactory epithelial cell" xsd:string property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-08-26T01:47:13Z [Term] id: CL:0002168 name: border cell of cochlea def: "A border cell is a slender columnar cell on the medial portion of the basilar membrane." [FMA:0412046911, GOC:tfm] subset: human_subset subset: mouse_subset xref: FMA:79798 is_a: CL:0002315 ! supporting cell of cochlea property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-08-25T01:47:12Z [Term] id: CL:0002169 name: basal cell of olfactory epithelium alt_id: CL:1000395 def: "An epithelial cell located on the basal lamina of the olfactory epithelium." [GOC:tfm, PMID:7143026] subset: human_subset subset: mouse_subset synonym: "horizontal basal cell" BROAD [] xref: FMA:62303 is_a: CL:0002167 {is_inferred="true"} ! olfactory epithelial cell intersection_of: CL:0002167 ! olfactory epithelial cell intersection_of: BFO:0000050 UBERON:0000482 ! part of basal lamina of epithelium relationship: BFO:0000050 UBERON:0000482 ! part of basal lamina of epithelium property_value: skos:prefLabel "basal cell of olfactory epithelium" xsd:string property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-08-26T01:58:54Z [Term] id: CL:0002170 name: keratinized cell of the oral mucosa def: "A keratinized cell located in the hard palate or gingiva." [GOC:tfm, PMID:12014572] subset: human_subset subset: mouse_subset is_a: CL:0000237 ! keratinizing barrier epithelial cell is_a: CL:0002336 ! buccal mucosa cell intersection_of: CL:0000237 ! keratinizing barrier epithelial cell intersection_of: BFO:0000050 UBERON:0003729 ! part of mouth mucosa relationship: BFO:0000050 UBERON:0003729 ! part of mouth mucosa property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-08-26T02:51:30Z [Term] id: CL:0002171 name: globose cell of olfactory epithelium def: "A rounded or elliptical epithelial cell, with pale-staining open face nucleus and pale cytoplasm rich in free ribosomes and clusters of centrioles; form a distinct basal zone spaced slightly from the basal surface of the epithelium." [GOC:tfm, PMID:17468753] subset: human_subset subset: mouse_subset synonym: "blastema cell of olfactory epithelium" EXACT [] xref: FMA:67874 is_a: CL:0002169 ! basal cell of olfactory epithelium property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-08-26T01:59:18Z [Term] id: CL:0002172 name: interdental cell of cochlea def: "A long, spindle-shaped supporting cells arranged in parallel rows that secretes components of the tectorial membrane and potassium ions into the endolymph." [GOC:tfm, MP:0004482, PMID:2111803] subset: human_subset subset: mouse_subset synonym: "interdental cell" EXACT [] xref: FMA:79797 is_a: CL:0002315 ! supporting cell of cochlea relationship: BFO:0000050 UBERON:0002276 ! part of lamina of spiral limbus property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-08-25T02:02:48Z [Term] id: CL:0002173 name: extraglomerular mesangial cell def: "A cell that is a specialized type of pericyte providing structural support for the capillary loops of kidney. A flat, elongated cell with extensive fine cytoplasmic processes found outside the kidney glomerulus near the macula densa and bound laterally by afferent and efferent arterioles. Being phagocytic, this cell participates in the continuous turnover of the basal lamina by removing its outer portion containing residues of filtration, while the lamina is renewed on its inner surface by the endothelial cells." [GOC:tfm, http:/www.copewithcytokines.de/cope.cgi?key=Lacis%20cells, ISBN:0412046911] subset: human_subset subset: mouse_subset synonym: "Goormaghtigh cell" EXACT [] synonym: "lacis cell" RELATED [] synonym: "polar cushion cells" EXACT [] xref: FMA:84143 xref: KUPO:0001033 is_a: CL:0000650 ! mesangial cell is_a: CL:1000618 {is_inferred="true"} ! juxtaglomerular complex cell intersection_of: CL:0002320 ! connective tissue cell intersection_of: BFO:0000050 UBERON:0002321 ! part of extraglomerular mesangium relationship: BFO:0000050 UBERON:0002321 ! part of extraglomerular mesangium property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-08-25T02:20:55Z [Term] id: CL:0002174 name: follicular cell of ovary def: "A cell within the follicle of an ovary." [GOC:tfm] subset: human_subset subset: mouse_subset xref: EMAPA:31247 xref: FMA:70589 is_a: CL:0000255 ! eukaryotic cell intersection_of: CL:0000000 ! cell intersection_of: BFO:0000050 UBERON:0001305 ! part of ovarian follicle relationship: BFO:0000050 UBERON:0001305 ! part of ovarian follicle property_value: RO:0002161 NCBITaxon:50557 {source="https://github.com/obophenotype/cell-ontology/issues/589"} property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-08-25T03:01:27Z [Term] id: CL:0002175 name: primary follicular cell of ovary def: "A cell within the primary follicle of the ovary." [GOC:tfm] subset: human_subset subset: mouse_subset xref: FMA:70590 is_a: CL:0002174 ! follicular cell of ovary property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-08-25T03:03:42Z [Term] id: CL:0002176 name: secondary follicular cell of ovary def: "A cell of a secondary follicile within the ovary." [GOC:tfm] subset: human_subset subset: mouse_subset xref: FMA:70591 is_a: CL:0002174 ! follicular cell of ovary property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-08-25T03:03:48Z [Term] id: CL:0002177 name: folliculostellate cell of pars distalis of adenohypophysis def: "A supporting cell of the anterior pituitary gland involved in trophic and catabolic processes; expresses a broad spectrum of cytokeratins indicative of their epithelial nature." [GOC:tfm] subset: human_subset subset: mouse_subset synonym: "folliculostellate cell of pars anterior of adenohypophysis" EXACT [] xref: FMA:83102 is_a: CL:0000642 {is_inferred="true"} ! folliculostellate cell is_a: CL:0000710 ! neurecto-epithelial cell intersection_of: CL:0000642 ! folliculostellate cell intersection_of: BFO:0000050 UBERON:0006964 ! part of pars distalis of adenohypophysis relationship: BFO:0000050 UBERON:0006964 ! part of pars distalis of adenohypophysis property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-08-25T03:10:10Z [Term] id: CL:0002178 name: epithelial cell of stomach alt_id: CL:1000399 def: "An epithelial cell found in the lining of the stomach." [GOC:tfm] subset: cellxgene_subset subset: human_subset subset: mouse_subset xref: FMA:62948 is_a: CL:0002251 {is_inferred="true"} ! epithelial cell of alimentary canal intersection_of: CL:0000066 ! epithelial cell intersection_of: BFO:0000050 UBERON:0001276 ! part of epithelium of stomach relationship: BFO:0000050 UBERON:0001276 ! part of epithelium of stomach property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-08-25T03:22:08Z [Term] id: CL:0002179 name: foveolar cell of stomach def: "A simple columnar cell that populates the entire luminal surface including the gastric pits. This cell types secrete mucus to form a thick protective, lubricant layer over the gastric wall." [GOC:tfm, ISBN:0517223651, Wikipedia:Foveolar_cell] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "surface mucosal cell of stomach" EXACT [] xref: FMA:62949 xref: FMA:86552 is_a: CL:0000075 ! columnar/cuboidal epithelial cell is_a: CL:0002180 ! mucous cell of stomach property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-08-25T03:23:22Z [Term] id: CL:0002180 name: mucous cell of stomach alt_id: CL:1000404 def: "An epithelial cell of the stomach. This cell produces mucous." [GOC:tfm] subset: cellxgene_subset subset: human_subset subset: mouse_subset xref: FMA:63464 is_a: CL:0000319 ! mucus secreting cell is_a: CL:0002178 ! epithelial cell of stomach is_a: CL:1100001 ! secretory epithelial cell intersection_of: CL:0000066 ! epithelial cell intersection_of: BFO:0000050 UBERON:0001276 ! part of epithelium of stomach intersection_of: RO:0002215 GO:0070254 ! capable of mucus secretion property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-08-25T03:38:51Z [Term] id: CL:0002181 name: mucous neck cell of gastric gland alt_id: CL:1000401 def: "A columnar epithelial mucous secreting cell located in the neck of the gastric glands. These cells have numerous apical secretory vesicles containing mucins and a basally displaced nucleus. The mucous they secrete is distinct histochemically from that of the surface mucous cells of stomach." [GOC:tfm, ISBN:0517223651] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "mucous neck cell" EXACT [] synonym: "neck cell" BROAD [] xref: FMA:62954 is_a: CL:0000075 ! columnar/cuboidal epithelial cell is_a: CL:0000152 ! exocrine cell is_a: CL:0002180 ! mucous cell of stomach is_a: CL:0002659 ! glandular epithelial cell of stomach relationship: BFO:0000050 UBERON:0000325 ! part of gastric gland relationship: BFO:0000051 GO:0098594 ! has part mucin granule property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 property_value: terms:contributor https://orcid.org/0009-0005-7919-4905 property_value: terms:date "2025-02-21T11:14:30Z" xsd:dateTime creation_date: 2010-08-25T03:41:30Z [Term] id: CL:0002182 name: obsolete surface mucosal cell of stomach def: "OBSOLETE. A simple columnar cell that populates the entire luminal surface including the gastric pits. This cell types secrete mucus to form a thick protective, lubricant layer over the gastric wall." [GOC:tfm, ISBN:0517223651] comment: Duplicate with foveolar cell of stomach xref: FMA:62949 property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 is_obsolete: true replaced_by: CL:0002179 creation_date: 2010-08-25T03:45:10Z [Term] id: CL:0002183 name: stem cell of gastric gland alt_id: CL:1000400 def: "A stomach epithelial cell that is olumnar in form with a few short apical microvilli; relatively undifferentiated mitotic cell from which other types of gland are derived; few in number, situated in the isthmus region of the gland and base of the gastric pit." [GOC:tfm, ISBN:0517223651] subset: human_subset subset: mouse_subset xref: FMA:62953 is_a: CL:0000048 {is_inferred="true"} ! multi fate stem cell is_a: CL:0002178 ! epithelial cell of stomach intersection_of: CL:0000048 ! multi fate stem cell intersection_of: BFO:0000050 UBERON:0000325 ! part of gastric gland relationship: BFO:0000050 UBERON:0000325 ! part of gastric gland property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-08-25T03:57:08Z [Term] id: CL:0002184 name: basal proper cell of olfactory epithelium def: "A flat or angular epithelial cell with condensed nuclei and darkly staining cytoplasm containing numerous intermediate filaments inserted into desmosomes contacting surrounding supporting cells; lie in contact with the basal lamina of olfactory epithelium." [GOC:tfm, PMID:0517223651, PMID:11891623] subset: human_subset subset: mouse_subset synonym: "horizontal basal cells" EXACT [] xref: FMA:62304 is_a: CL:0002169 ! basal cell of olfactory epithelium property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-08-26T01:59:22Z [Term] id: CL:0002187 name: basal cell of epidermis alt_id: CL:1000439 def: "A mitotically active, columnar-shaped keratinocyte located in the stratum basale of the epidermis and attached to the basement membrane. This cell exhibits heterogeneity, encompassing stem and progenitor subpopulations with distinct molecular and proliferative characteristics (Haensel et al., 2020), and serves as the primary source of new keratinocytes for epidermal renewal, homeostasis, and regeneration." [doi:/10.1073/pnas.1734203100, GOC:tfm, ISBN:0517223651, PMID:16824012, PMID:32187560, WIKIPEDIA:Basal_cell] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "epidermal basal cell" EXACT [PMID:32187560] synonym: "epidermal basal keratinocyte" EXACT [PMID:7058342] xref: FMA:70571 is_a: CL:0000646 ! basal cell is_a: CL:0011026 ! progenitor cell is_a: CL:1000428 ! stem cell of epidermis is_a: CL:4052061 ! epidermal keratinocyte intersection_of: CL:0000646 ! basal cell intersection_of: BFO:0000050 UBERON:0002025 ! part of stratum basale of epidermis relationship: BFO:0000050 UBERON:0002025 ! part of stratum basale of epidermis relationship: RO:0002215 GO:0030216 ! capable of keratinocyte differentiation property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0002187" xsd:string {name="basal cell of epidermis on CELLxGENE CellGuide"} property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 property_value: terms:description "The basal cells of the epidermis make up the innermost layer of the skin, providing an essential structural component to the body's largest organ. These cuboidal-shaped cells are critical to the skin's renewal process, dividing to form new keratinocytes that gradually make their way to the skin’s surface. The migration of these cells creates a protective barrier that impedes damage from environmental factors like sunlight, radiation, and harmful pathogens.\nBasal cells have an additional, pivotal role beyond formation and migration of keratinocytes: they are also directly involved in the production of various types of skin appendages, including hair follicles, sebaceous glands, and sweat glands. Coupled with their prolific regenerative properties, these functions make basal cells vital for maintaining the skin's overall health and vitality.\nChanges and mutations in the formation and growth of basal cells of the epidermis can lead to cancerous lesions. Though usually not life-threatening, early identification is critical to minimizing further tissue damage.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1007/s12015-021-10256-1", xref="DOI:10.1172/JCI58779", xref="DOI:10.1186/s41038-016-0064-6", xref="DOI:10.7748/ns.27.3.35.s52"} creation_date: 2010-08-26T03:12:49Z [Term] id: CL:0002188 name: glomerular endothelial cell def: "An endothelial cell that is part of the glomerulus of the kidney. This cell is flattened, highly fenestrated, and plays a vital role in the formation of glomerular ultrafiltrate." [GOC:tfm, PMID:15840009] comment: Glomerular endothelial cells have 60-80 nm fenestrations typically lacking diaphragms in adults but present during embryonic development. Some studies found diaphragms in 2-6% of mature rat glomerular capillaries. Their presence may depend on fixation techniques, developmental stage, or dynamic cell changes. Additionally, these cells help maintain the structural integrity of glomerular capillaries through interactions with the basement membrane and podocytes. {xref="PMID:33123011", xref="PMID:18480313", xref="PMID:19129259"} subset: cellxgene_subset subset: human_subset subset: kidney_upper_slim subset: mouse_subset xref: BTO:0004632 xref: FMA:70970 is_a: CL:0000666 ! fenestrated endothelial cell is_a: CL:0002681 ! kidney cortical cell intersection_of: CL:0000115 ! endothelial cell intersection_of: BFO:0000050 UBERON:0000074 ! part of renal glomerulus relationship: BFO:0000050 UBERON:0000074 ! part of renal glomerulus relationship: BFO:0000051 GO:0036053 ! has part glomerular endothelium fenestra property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-08-26T10:59:44Z [Term] id: CL:0002189 name: granular cell of epidermis def: "A keratinocyte located in the stratum granulosum of the epidermis, characterized by the presence of keratohyalin granules containing filaggrin—which aggregate keratin filament —and by lamellar granules that secrete lipids and enzymes essential for forming the skin’s waterproof barrier. As these cells progress toward the surface, they adopt a flattened morphology and initiate keratinization to become corneocyte and form the protective stratum corneum. In human epidermis, granular keratinocytes are transcriptomically distinguished by high expression of differentiation markers such as DSC1, KRT2, IVL, and TGM3 (Wang et al., 2020), and LOR, FLG, and SPINK5 (Cheng et al., 2018)." [ISBN:1416031855, PMID:29262154, PMID:30355494, PMID:30725734, PMID:32843640, WIKIPEDIA:Stratum_granulosum] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "granular keratinocyte" EXACT [PMID:32843640] xref: FMA:70543 is_a: CL:0000712 ! stratum granulosum cell is_a: CL:4052061 ! epidermal keratinocyte relationship: BFO:0000051 GO:0036457 ! has part keratohyalin granule relationship: BFO:0000051 GO:0097209 ! has part epidermal lamellar body property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-08-26T03:19:00Z [Term] id: CL:0002190 name: squamous cell of epidermis def: "A flat keratinocyte immediately below the cornified layer." [GOC:tfm, ISBN:0517223651] subset: human_subset subset: mouse_subset xref: FMA:86925 is_a: CL:4052061 ! epidermal keratinocyte property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-08-26T03:37:02Z [Term] id: CL:0002191 name: granulocytopoietic cell def: "A cell involved in the formation of a granulocyte." [GOC:tfm] subset: cellxgene_subset subset: human_subset subset: mouse_subset xref: FMA:83519 is_a: CL:0000839 {is_inferred="true"} ! myeloid lineage restricted progenitor cell intersection_of: CL:0000839 ! myeloid lineage restricted progenitor cell intersection_of: RO:0002215 GO:0030851 ! capable of granulocyte differentiation relationship: RO:0002215 GO:0030851 ! capable of granulocyte differentiation property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-08-30T12:54:27Z [Term] id: CL:0002192 name: metamyelocyte def: "A eosinophil precursor in the granulocytic series, being a cell intermediate in development between a myelocyte and a band form cell. The nucleus becomes indented where the indentation is smaller than half the distance to the farthest nuclear margin; chromatin becomes coarse and clumped; specific granules predominate while primary granules are rare." [GOC:tfm, http://en.wikipedia.org/wiki/Metamyelocyte, ISBN:0721601464] subset: cellxgene_subset subset: human_subset subset: mouse_subset xref: FMA:83541 is_a: CL:0000763 ! myeloid cell is_a: CL:0002191 ! granulocytopoietic cell relationship: RO:0002202 CL:0002193 ! develops from myelocyte property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-08-30T01:08:15Z [Term] id: CL:0002193 name: myelocyte def: "A cell type that is the first of the maturation stages of the granulocytic leukocytes normally found in the bone marrow. Granules are seen in the cytoplasm. The nuclear material of the myelocyte is denser than that of the myeloblast but lacks a definable membrane. The cell is flat and contains increasing numbers of granules as maturation progresses." [GOC:tfm, http://en.wikipedia.org/wiki/Myelocyte, ISBN:0323052908] subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset xref: BTO:0000734 xref: FMA:83525 is_a: CL:0000763 ! myeloid cell is_a: CL:0002191 ! granulocytopoietic cell relationship: RO:0002202 CL:0000836 ! develops from promyelocyte property_value: RO:0002175 NCBITaxon:9606 property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0002193" xsd:string {name="myelocyte on CELLxGENE CellGuide"} property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 property_value: terms:description "A myelocyte is a type of immature granulocyte found in the bone marrow during the production of blood cells, a process known as hematopoiesis. Myelocytes represent an intermediate stage in the development of granulocytes, which are a type of white blood cell essential for the immune system. The three kinds of granulocytes that derive from myelocytes are neutrophils, eosinophils, and basophils, each with distinct properties and functions. Myelocytes possess some functionalities of a mature cell such as the presence of specific granules.\nThe main function of myelocytes is to differentiate into mature granulocytes. The process starts with a hematopoietic stem cell, which progressively matures into a myeloblast, and further into a promyelocyte before eventually becoming a myelocyte. At this stage, the cell begins producing granules that carry specific enzymes and other substances used to fight infections. The most common type of myelocyte is the neutrophilic myelocyte, which eventually develops into a neutrophil, the most common type of white blood cell.\nNeutrophilic myelocytes contribute significantly to the body's primary immune response as mature neutrophils are often the first cells to arrive at a site of infection. They ingest and destroy bacteria and other harmful agents to prevent further infection. Eosinophilic and basophilic myelocytes develop into eosinophils and basophils, respectively, playing their role in managing allergic reactions and parasitic infections. Dysfunction in myelocyte development can give rise to various diseases, including different forms of leukemia, where myelocytes undergo uncontrolled proliferation.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1038/s41375-023-01989-8", xref="DOI:10.1182/blood.V71.3.640.640", xref="https://www.sciencedirect.com/topics/biochemistry-genetics-and-molecular-biology/myelocyte", xref="https://www.sciencedirect.com/topics/medicine-and-dentistry/granulopoiesis"} creation_date: 2010-08-30T01:08:19Z [Term] id: CL:0002194 name: monopoietic cell def: "A cell involved in the formation of a monocyte (monopoiesis)." [GOC:tfm] subset: human_subset subset: mouse_subset xref: FMA:83552 is_a: CL:0000839 {is_inferred="true"} ! myeloid lineage restricted progenitor cell intersection_of: CL:0000839 ! myeloid lineage restricted progenitor cell intersection_of: RO:0002215 GO:0030224 ! capable of monocyte differentiation relationship: RO:0002215 GO:0030224 ! capable of monocyte differentiation property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-08-30T01:27:48Z [Term] id: CL:0002195 name: hepatic stem cell def: "A stem cell that can give rise to the cells of the liver. The term usually refers to the self-renewing pool of hepatocyte precursors in the adult liver (differently from 'hepatoblast', often used for fetal precursors of hepatocytes)." [GOC:tfm, PMID:26798363] subset: human_subset subset: mouse_subset synonym: "HpSC" RELATED OMO:0003000 [PMID:18442648] xref: FMA:86577 is_a: CL:0000048 {is_inferred="true"} ! multi fate stem cell intersection_of: CL:0000048 ! multi fate stem cell intersection_of: BFO:0000050 UBERON:0002107 ! part of liver relationship: BFO:0000050 UBERON:0002107 ! part of liver property_value: seeAlso "https://github.com/obophenotype/cell-ontology/issues/800" xsd:string property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-08-30T02:00:42Z [Term] id: CL:0002196 name: hepatic oval stem cell alt_id: CL:1000036 def: "A transient hepatic stem cell observed after liver injury with a high nuclear to cytoplasm ratio that can differentiate into mature hepatocytes and bile duct cells. Arises from more than one tissue." [PMID:17901986] subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "hepatic oval cell" EXACT [] synonym: "hepatic progenitor cell" EXACT [https://doi.org/10.1038/s12276-020-0483-0] {terms:contributor="http://orcid.org/0000-0003-1940-6740"} synonym: "liver progenitor cell" EXACT [https://doi.org/10.1038/s12276-020-0483-0] xref: BTO:0004270 xref: FMA:86576 is_a: CL:0011026 ! progenitor cell relationship: BFO:0000050 UBERON:0002107 ! part of liver property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/2d-ftu/liver-liver-lobule/v1.3/assets/2d-ftu-liver-liver-lobule.png" xsd:string {terms:licence="http://creativecommons.org/licenses/by/4.0/", xref="doi:10.48539/HBM889.CJPK.447"} property_value: RO:0002175 NCBITaxon:9606 property_value: RO:0004050 "Liver progenitor cells have been variously named in rodent and human studies as oval cells, hepatic progenitor cells, liver stem cells, ductular reactions, or atypical ductular cells. They were first described as oval cells in rats due to their large nuclear-to-cytoplasm ratio and oval-shaped nuclei. On the difference between 'hepatic liver stem cells' (HLSC) and 'oval cells': \"... unlike a well-known hepatic progenitor cell population, known as oval cells in rodents, HLSCs do not express CK-7, CK-19, c-kit, CD133 and alpha-smooth muscle actin (α-SMA) (Gaudio et al., 2009)\"." xsd:string {xref="https://doi.org/10.1038/s12276-020-0483-0", xref="https://doi.org/10.3389/fcell.2021.644088"} property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-08-30T02:01:49Z [Term] id: CL:0002197 name: inactive chief cell of parathyoid gland def: "A parathyroid chief cell that is not actively secreting hormone. Contains small Golgi complexes with only a few grouped vesicles and membrane-bound secretory granules; glycogen and many lipofuscin granules abound but sacs of granular endoplasmic reticulum are rare and dispersed. In normal humans, inactive chief cells out number active chief cells in a ratio of 3-5:1." [GOC:tfm, ISBN:0517223651] subset: human_subset subset: mouse_subset is_a: CL:0000446 ! chief cell of parathyroid gland property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-09-02T11:14:01Z [Term] id: CL:0002198 name: oncocyte def: "A large epithelial cell with an extremely acidophilic and granular cytoplasm, containing vast numbers of mitochondria; such cells may undergo neoplastic transformation. From the Greek word onkos meaning swelling, this cell type is found in parathyroid, salivary and thyroid glands." [GOC:tfm, ISBN:0721662544, PMID:20013317] subset: human_subset subset: mouse_subset synonym: "oxyphil" EXACT [] xref: FMA:67606 xref: MESH:D024862 is_a: CL:0002076 ! endo-epithelial cell property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-09-02T11:26:49Z [Term] id: CL:0002199 name: oxyphil cell of parathyroid gland def: "An oncocyte located in the parathyroid gland." [PMID:20013317] subset: human_subset subset: mouse_subset xref: FMA:69084 is_a: CL:0002198 ! oncocyte is_a: CL:0002260 ! epithelial cell of parathyroid gland property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-09-02T11:33:23Z [Term] id: CL:0002200 name: oxyphil cell of thyroid def: "An oncocyte located in the thyroid." [GOC:tfm, PMID:20013317] subset: human_subset subset: mouse_subset synonym: "Askanazy cells" EXACT [] synonym: "Hurthle cells" EXACT [] xref: FMA:87169 is_a: CL:0002198 ! oncocyte is_a: CL:0002257 ! epithelial cell of thyroid gland intersection_of: CL:0002198 ! oncocyte intersection_of: BFO:0000050 UBERON:0002046 ! part of thyroid gland property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-09-02T11:33:26Z [Term] id: CL:0002201 name: renal beta-intercalated cell def: "A renal intercalated cell that secretes base and reabsorbs acid in the distal segments of the kidney tubule to maintain acid/base balance." [GOC:tfm, PMID:11781354, PMID:25632105] subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "type B intercalated cell" EXACT [PMID:25632105] synonym: "type B-IC" EXACT [PMID:25632105] is_a: CL:0005010 ! renal intercalated cell property_value: RO:0002175 NCBITaxon:9606 property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-09-02T01:43:55Z [Term] id: CL:0002202 name: epithelial cell of tracheobronchial tree alt_id: CL:1000407 def: "An epithelial cell of the tracheobronchial tree." [GOC:tfm] subset: human_subset subset: mouse_subset xref: FMA:66816 is_a: CL:0002632 ! epithelial cell of lower respiratory tract intersection_of: CL:0000066 ! epithelial cell intersection_of: BFO:0000050 UBERON:0008397 ! part of tracheobronchial epithelium relationship: BFO:0000050 UBERON:0008397 ! part of tracheobronchial epithelium property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-09-02T02:09:14Z [Term] id: CL:0002203 name: tuft cell of large intestine alt_id: CL:1000387 def: "A tuft cell that is part of the epithelium of large intestine." [GOC:tfm, PMID:35271673] comment: Brush cells are a distinct cell type from brush border cell-types. subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "brush cell of epithelium proper of large intestine" EXACT [] synonym: "brush cell of large intestine" EXACT [http://orcid.org/0000-0003-4183-8865] synonym: "tuft cell of epithelium of large intestine" EXACT [http://orcid.org/0000-0003-4183-8865] xref: FMA:263222 is_a: CL:0002253 ! epithelial cell of large intestine is_a: CL:0019032 ! intestinal tuft cell intersection_of: CL:0002204 ! tuft cell intersection_of: BFO:0000050 UBERON:0001278 ! part of epithelium of large intestine property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-09-02T02:20:50Z [Term] id: CL:0002204 name: tuft cell def: "An epithelial cell found in various organs, including the gastrointestinal and respiratory tracts, characterized by a tuft of 120-140 blunt microvilli on its apical surface. This cell exhibits diverse functions depending on its location, which includes chemosensation, initiation of immune responses, contribution to mucociliary clearance, and defense against parasites." [GOC:tfm, ISBN:0517223651, PMID:15817800, PMID:30379593, PMID:36704202] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "brush cell" EXACT [PMID:36704202] synonym: "caveolated cell" EXACT [PMID:36704202] synonym: "fibrillovesicular cell" EXACT [PMID:36704202] synonym: "multivesicular cell" EXACT [PMID:32307399] synonym: "peculiar cell" EXACT [PMID:36704202] xref: FMA:67978 is_a: CL:0000066 ! epithelial cell intersection_of: CL:0000066 ! epithelial cell intersection_of: BFO:0000051 GO:0151001 ! has part tuft relationship: BFO:0000051 GO:0151001 ! has part tuft property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0002204" xsd:string {name="tuft cell on CELLxGENE CellGuide"} property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 property_value: terms:description "Brush cells, also referred to as tuft cells or multivesicular cells, are a specialized type of epithelial cell mainly noted for their characteristic 'brush border' composed of microvilli. These cells reside in the epithelial lining of tissue organs such as the respiratory tract, gastrointestinal tract, and the bile ducts. The name derives from their distinct appearance under the microscope, which resembles a brush due to the dense layer of microvilli protruding into the lumen.\nA key function of brush cells is chemosensation: They express a variety of signaling molecules and receptors that enable them to detect specific chemical stimuli in the environment and act as sensory transducers. Many of these receptors are responsive to luminal content, which makes brush cells vital for regulating and coordinating appropriate physiological responses to changes in these substances. \nRecent research has also elucidated an important role for these cells in immunity. Intestinal brush cells have been found to be the source of a cytokine called interleukin-25, which can initiate type 2 immune responses during parasitic infections. This immune function, along with the chemosensing abilities, signifies that brush cells could serve crucial roles in health and disease, although much research is still required to fully elucidate their myriad roles in physiology and pathology. Overall, brush cells are a versatile cell type, whose distinct morphology and functional capabilities allow them to perform a unique set of functions within the body.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1007/978-3-211-99390-3_83", xref="DOI:10.1038/nature16161", xref="DOI:10.1111/j.1469-7580.2005.00403.x", xref="DOI:10.3389/fphys.2015.00087", xref="DOI:10.5114/ceji.2022.124416"} creation_date: 2010-09-02T02:28:53Z [Term] id: CL:0002205 name: brush cell of lobular bronchiole alt_id: CL:1000386 def: "A brush cell found in the epithelium of lobular bronchiole." [GOC:tfm] subset: human_subset subset: mouse_subset xref: FMA:263220 is_a: CL:0000082 ! epithelial cell of lung is_a: CL:0002075 ! brush cell of tracheobronchial tree intersection_of: CL:0002204 ! tuft cell intersection_of: BFO:0000050 UBERON:8600001 ! part of epithelium of lobular bronchiole relationship: BFO:0000050 UBERON:8600001 ! part of epithelium of lobular bronchiole property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-09-02T02:38:34Z [Term] id: CL:0002206 name: brush cell of terminal bronchiole alt_id: CL:1000390 def: "A brush cell of the epithelium in the terminal bronchiole." [GOC:tfm] subset: human_subset subset: mouse_subset xref: FMA:263228 is_a: CL:0000082 ! epithelial cell of lung is_a: CL:0002075 ! brush cell of tracheobronchial tree intersection_of: CL:0002204 ! tuft cell intersection_of: BFO:0000050 UBERON:0001958 ! part of terminal bronchiole epithelium relationship: BFO:0000050 UBERON:0001958 ! part of terminal bronchiole epithelium property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-09-02T02:38:36Z [Term] id: CL:0002207 name: brush cell of trachea alt_id: CL:1000388 def: "Brush cell of the epithelium in the trachea." [GOC:tfm] subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset xref: FMA:263224 is_a: CL:0000307 {is_inferred="true"} ! tracheal epithelial cell is_a: CL:0002075 {is_inferred="true"} ! brush cell of tracheobronchial tree intersection_of: CL:0002204 ! tuft cell intersection_of: BFO:0000050 UBERON:0001901 ! part of epithelium of trachea relationship: BFO:0000050 UBERON:0001901 ! part of epithelium of trachea property_value: RO:0002175 NCBITaxon:9606 property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0002207" xsd:string {name="brush cell of trachea on CELLxGENE CellGuide"} property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 property_value: terms:description "The brush cell of the trachea is a specialized cell type located predominantly in the epithelial lining of the trachea. Brush cells, also called tuft cells, are named for their distinctive morphology - a broad base leading to a narrower apex, adorned with a tuft of rigid, long microvilli resembling a brush. The cells are columnar and among the smallest in the respiratory tract, yet their appearance sets them apart from the typical ciliated cells that make up the majority of the tracheal epithelium. \nBrush cells are believed to serve a role as chemosensory sentinels in the trachea, monitoring the biochemical environment. The ‘brush’ or ‘tuft’ serves a critical purpose in heightening the cell's sense of contact with its surroundings. Brush cells of the trachea are equipped with taste receptors and a taste transduction machinery, such as the cation channel TRPM5 (transient receptor potential melastatin 5). Following activation through bitter-taste receptors, brush cells initiate downstream signaling to sensory neurons which then leads to protective respiratory nerve reflexes. \nRecent research has also shown that tracheal brush cells not only detect pathogenic substances but also contribute to the antimicrobial host defense by releasing neuropeptides that ultimately direct an influx of innate immune cells.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1164/rccm.200502-203WS", xref="DOI:10.1172/JCI161439"} creation_date: 2010-09-02T02:38:37Z [Term] id: CL:0002208 name: brush cell of bronchus alt_id: CL:1000389 def: "A brush cell found in the epithelium of bronchus." [GOC:tfm] subset: human_reference_atlas subset: human_subset subset: mouse_subset xref: FMA:263226 is_a: CL:0002075 ! brush cell of tracheobronchial tree is_a: CL:0002328 ! bronchial epithelial cell intersection_of: CL:0002204 ! tuft cell intersection_of: BFO:0000050 UBERON:0002031 ! part of epithelium of bronchus property_value: RO:0002175 NCBITaxon:9606 property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0002208" xsd:string {name="brush cell of bronchus on CELLxGENE CellGuide"} property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 property_value: terms:description "Brush cells of the bronchus, also known as bronchial brush cells or tuft cells, are specialized epithelial cells found in the respiratory tract, specifically within the bronchi. These are called 'brush cells' due to their distinctive appearance, characterized by their apical surface being enveloped by a dense collection of long, thin, rigid microvilli, often likened to bristles of a brush. Some sources also describe them as having a bottle-like shape, with an enlarged middle section that narrows towards the base.\nThe primary function of brush cells in the respiratory tract is chemosensation. They have the built-in capacity to sense changes in their chemical environments. Brush cells of the bronchi are equipped with a host of sensory receptors, including bitter-taste receptors, which allow them to detect and respond to a wide array of airborne substances. Several studies also indicate the potential roles these cells play in initiating signal transduction pathways that regulate local airway behaviors such as bronchoconstriction, mucus secretion and immune responses.\nRecent research also suggests that brush cells of the bronchus could potentially play a role in immune surveillance. They might can react to harmful pathogenic invasions in the airway by releasing certain compounds that aid in attracting immune cells to the site of infection. An increase in the number of brush cells has also been reported in certain lung diseases, suggesting a possible involvement in pathological processes. Although the precise role of bronchial brush cells continue to be the subject of ongoing research, they contribute to maintaining the overall integrity and function of the bronchial epithelium.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1164/rccm.200502-203WS", xref="DOI:10.1172/JCI161439", xref="DOI:10.1186/s12931-023-02570-8"} creation_date: 2010-09-02T02:38:42Z [Term] id: CL:0002209 name: intermediate epitheliocyte def: "An epithelial cell present in the trachea and bronchi; columnar in shape; generally lack cilia; immature forms of ciliated or secretory cells which have been formed from stem cells." [GOC:tfm, ISBN:0517223651] subset: human_subset subset: mouse_subset synonym: "undifferentiated columnar cell of tracheobronchial tree" EXACT [] xref: FMA:69060 is_a: CL:0002202 ! epithelial cell of tracheobronchial tree property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-09-02T02:53:59Z [Term] id: CL:0002210 name: red muscle cell def: "A slow muscle cell that contains high levels of myoglobin and oxygen storing proteins giving the cell a red appearance." [GOC:tfm, ISBN:0517223651] subset: human_subset subset: mouse_subset synonym: "oxidative muscle fiber" EXACT [] synonym: "red muscle fiber" EXACT [] xref: FMA:84448 is_a: CL:0008046 ! extrafusal muscle fiber property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-09-02T03:20:03Z [Term] id: CL:0002211 name: type I muscle cell def: "A slow muscle cell that has large amounts of myoglobin, stores energy as triglycerides, generates ATP by the oxidative method and is resistant to fatigue." [GOC:tfm, ISBN:0517223651] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "intermediate muscle fiber" RELATED [MESH:D018657] synonym: "slow twitch fiber" EXACT [] synonym: "slow twitch muscle cell" EXACT [] synonym: "slow twitch muscle fiber" EXACT [MESH:D018657] synonym: "slow-twitch muscle fiber" EXACT [MESH:D018657] synonym: "type 1 muscle cell" EXACT [] synonym: "type 1 muscle fiber" EXACT [] synonym: "type I muscle fiber" EXACT [] xref: BTO:0001812 xref: CALOHA:TS-0940 xref: FMA:84413 is_a: CL:0000189 ! slow muscle cell is_a: CL:0002210 ! red muscle cell property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-09-02T03:24:05Z [Term] id: CL:0002212 name: type II muscle cell def: "A fast muscle fiber cell that stores energy in the form of glycogen and creatine phosphate." [GOC:tfm] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "type 2 muscle cell" EXACT [] synonym: "type 2 muscle fiber" EXACT [] synonym: "type II muscle fiber" EXACT [] xref: BTO:0001813 xref: FMA:84414 is_a: CL:0000190 ! fast muscle cell property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-09-02T03:28:45Z [Term] id: CL:0002213 name: white muscle cell def: "A muscle cell with low content of myoglobin and other oxygen storing proteins. This muscle cell has a white appearance." [GOC:tfm, ISBN:0517223651] subset: human_subset subset: mouse_subset xref: FMA:84449 is_a: CL:0000190 ! fast muscle cell property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-09-02T03:28:48Z [Term] id: CL:0002214 name: type IIa muscle cell def: "A type II muscle cell that contains large amounts of myoglobin, has many mitochondria and very many blood capillaries. Type II A cells are red, have a very high capacity for generating ATP by oxidative metabolic processes, split ATP at a very rapid rate, have a fast contraction velocity and are resistant to fatigue." [GOC:tfm] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "fast twitch A" EXACT [] synonym: "fatigue resistant fast twitch muscle cell" EXACT [] synonym: "type 2a muscle cell" EXACT [] synonym: "type 2a muscle fiber" EXACT [] synonym: "type IIa muscle fiber" EXACT [] xref: BTO:0001813 xref: FMA:84415 is_a: CL:0002210 ! red muscle cell is_a: CL:0002212 ! type II muscle cell property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-09-02T03:31:38Z [Term] id: CL:0002215 name: type IIb muscle cell def: "A type II muscle cell that contains a low content of myoglobin, relatively few mitochondria, relatively few blood capillaries and large amounts of glycogen. Type II B fibres are white, geared to generate ATP by anaerobic metabolic processes, not able to supply skeletal muscle fibres continuously with sufficient ATP, fatigue easily, split ATP at a fast rate and have a fast contraction velocity." [GOC:tfm, http://en.wikipedia.org/wiki/Skeletal_muscle, ISBN:0517223651] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "type 2b muscle cell" EXACT [] synonym: "type 2b muscle fiber" EXACT [] synonym: "type IIb muscle fiber" EXACT [] xref: FMA:84416 is_a: CL:0002212 ! type II muscle cell is_a: CL:0002213 ! white muscle cell property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-09-02T03:31:42Z [Term] id: CL:0002216 name: intermediate muscle cell def: "An intermediate muscle cell that has characteristics of both fast and slow muscle cells." [GOC:tfm] subset: cellxgene_subset subset: human_subset subset: mouse_subset xref: FMA:84450 is_a: CL:0008046 ! extrafusal muscle fiber property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-09-02T03:51:17Z [Term] id: CL:0002217 name: intermediate trophoblast cell def: "A trophoblast that leaves the placenta and invades the endometrium and myometrium. This cell type is crucial in increasing blood flow to the fetus." [GOC:tfm, http://www.med.yale.edu/obgyn/kliman/placenta/articles/EOR_Placenta/Trophtoplacenta.html] subset: human_subset subset: mouse_subset xref: BTO:0002366 xref: FMA:86564 is_a: CL:0000351 ! trophoblast cell property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-09-02T04:04:36Z [Term] id: CL:0002218 name: immature dendritic epithelial T cell precursor def: "A double negative thymocyte that has a T cell receptor consisting of a gamma chain that has as part a Vgamma3 segment, and a delta chain. This cell type is CD4-negative, CD8-negative and CD24-positive. This cell-type is found in the fetal thymus with highest numbers occurring at E17-E18." [GOC:tfm, http://www.immgen.org] comment: NOTE: currently variable immune gene segments are not represented in the OBO Foundry. Cross-product definitions were not made as a result. Also, there are three different nomenclatures for the variable gamma segments. subset: human_subset subset: mouse_subset synonym: "immature DEC precursor" EXACT [] synonym: "immature DETC precursor" EXACT [] is_a: CL:0002404 ! fetal thymocyte property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-10-07T01:58:00Z [Term] id: CL:0002219 name: anchoring trophoblast def: "A trophoblast found at the junction of the placenta. This cell type makes a unique fibronectin-trophouteronectin junction that helps mediate attachment of the placenta to the uterus. This cell type is also found junction of the chorion layer of the external membranes and the decidua." [GOC:tfm, http://www.med.yale.edu/obgyn/kliman/placenta/articles/EOR_Placenta/Trophtoplacenta.html] subset: human_subset subset: mouse_subset is_a: CL:0000351 ! trophoblast cell property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-09-02T04:14:28Z [Term] id: CL:0002220 name: interstitial cell of pineal gland def: "A cell located between the pinealocytes." [GOC:tfm, ISBN:0517223651] subset: human_subset subset: mouse_subset xref: FMA:86575 is_a: CL:0000710 ! neurecto-epithelial cell property_value: skos:prefLabel "interstitial cell of pineal gland" xsd:string property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-09-02T04:28:41Z [Term] id: CL:0002221 name: keratinized squamous cell of esophagus def: "A squamous cell that has keratin in the esophagus." [GOC:tfm, PMID:11694559] subset: human_subset subset: mouse_subset xref: FMA:86549 is_a: CL:0000237 ! keratinizing barrier epithelial cell is_a: CL:0002252 ! epithelial cell of esophagus property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-09-07T10:11:06Z [Term] id: CL:0002222 name: vertebrate lens cell def: "A cell comprising the transparent, biconvex body separating the posterior chamber and vitreous body, and constituting part of the refracting mechanism of the mammalian eye." [GOC:tfm, ISBN:0721662544] subset: eye_upper_slim subset: human_subset subset: mouse_subset xref: FMA:70950 is_a: CL:0000066 ! epithelial cell is_a: CL:0000306 ! crystallin accumulating cell relationship: BFO:0000050 UBERON:0000965 ! part of lens of camera-type eye property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-09-07T10:38:03Z [Term] id: CL:0002223 name: anterior lens cell def: "A cell of the transparent layer of simple cuboidal epithelium over the anterior surface of the lens; transform into lens fiber(s)." [GOC:tfm, ISBN:0517223651] subset: cellxgene_subset subset: human_subset subset: mouse_subset xref: FMA:63181 is_a: CL:0002224 ! lens epithelial cell property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0002223" xsd:string {name="anterior lens cell on CELLxGENE CellGuide"} property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 property_value: terms:description "The anterior lens cells, also known as lens epithelial cells, are an integral part of the eye's structure and play a critical role in the organ's physiological functioning. They are situated in the anterior portion of the lens, precisely in the lens capsule, and stretch over the lens' frontal surface.\nThe primary function of anterior lens cells is to facilitate eye accommodation by controlling the shape and thickness of the eye lens.\nThe cells are involved in continuous proliferation, migration, and differentiation into lens fiber cells, helping to maintain lens growth and transparency. Anterior lens cells have a prolonged life span and reveal an extraordinary ability to function indefinitely, a characteristic that is critical for maintaining lens transparency. Damage or disturbance to the anterior lens cells can give rise to lens opacity, eventually leading to cataracts, which is a common cause of vision loss.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1016/j.biocel.2007.10.034", xref="DOI:10.1111/aos.14600", xref="DOI:10.1155/2021/9951032"} creation_date: 2010-09-07T10:45:45Z [Term] id: CL:0002224 name: lens epithelial cell def: "A cell of the cuboidal epithelium that covers the lens. The cells of the lens epithelium regulate most of the homeostatic functions of the lens. As ions, nutrients, and liquid enter the lens from the aqueous humor, Na+/K+ ATPase pumps in the lens epithelial cells pump ions out of the lens to maintain appropriate lens osmolarity and volume, with equatorially positioned lens epithelium cells contributing most to this current. The activity of the Na+/K+ ATPases keeps water and current flowing through the lens from the poles and exiting through the equatorial regions. The cells of the lens epithelium also serve as the progenitors for new lens fibers. It constantly lays down fibers in the embryo, fetus, infant, and adult, and continues to lay down fibers for lifelong growth." [GOC:tfm, http://en.wikipedia.org/wiki/Lens_%28anatomy%29#Lens_epithelium, ISBN:0721662544] subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset xref: FMA:67559 is_a: CL:0000075 {is_inferred="true"} ! columnar/cuboidal epithelial cell is_a: CL:0002222 ! vertebrate lens cell intersection_of: CL:0000075 ! columnar/cuboidal epithelial cell intersection_of: BFO:0000050 UBERON:0001803 ! part of epithelium of lens relationship: BFO:0000050 UBERON:0001803 ! part of epithelium of lens property_value: RO:0002175 NCBITaxon:9606 property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0002224" xsd:string {name="lens epithelial cell on CELLxGENE CellGuide"} property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 property_value: terms:description "Lens epithelial cells are specialized cells located in the anterior portion of the eye's lens, a crucial part of the visual system. These cells form a monolayer of cuboidal cells under the lens capsule known as the lens epithelium, which plays several key roles in maintaining the health and functionality of the ocular lens. \nLens epithelial cells are responsible for the synthesis, metabolism, and transport of various substances that make up the lens fibers. These cells ensure the lens maintains its transparency and refractive properties, crucial to the eye's capacity to focus light onto the retina. Lens epithelial cells are also able to divide and differentiate into lens fiber cells and therefore play a fundamental role in lens growth and development. \nThe lenses of some species are able to regenerate; the regeneration ability of lenses in higher mammals is relatively weak, but there has been some progress in using lens epithelial cells as endogenous stem cells to achieve the partial regeneration of lens tissue. \nIn pathological conditions such as cataracts, the function and behavior of lens epithelial cells can be disrupted, which can lead to cloudy or opaque areas in the lens that interfere with vision.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1016/j.biocel.2007.10.034", xref="DOI:10.1016/j.isci.2023.106921", xref="DOI:10.1016/j.preteyeres.2022.101112", xref="DOI:10.1242/dev.107953", xref="DOI:10.3389/fcell.2022.983178"} creation_date: 2010-09-07T10:45:47Z [Term] id: CL:0002225 name: secondary lens fiber def: "A lens fiber cell that develops from primary lens fiber; located towards the center of lens; cell organelles are normally degraded or in the process of being degraded." [GOC:tfm, ISBN:0517223651] subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "secondary lens fibre" EXACT [] is_a: BFO:0000002 is_a: CL:0011004 ! lens fiber cell relationship: RO:0002202 CL:0002228 ! develops from primary lens fiber property_value: RO:0002175 NCBITaxon:9606 property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0002225" xsd:string {name="secondary lens fiber on CELLxGENE CellGuide"} property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 property_value: terms:description "Secondary lens fibers are a specialized type of elongated cells located within the structure of the eye's lens. They play an essential role in vision by enabling light transmission and focus on the retina, which allows for clear, distinct vision. These cells are characterized by their lack of nuclei and organelles, their orderly alignment, and their high protein content, particularly crystallins. \nLens fibers are differentiated from equatorial epithelial cells of the lens in a process that involves cell elongation, denucleation and tight packing, which serve to reduce light scattering occurrences in the eye. This differentiation accelerates substantially after birth in comparison to during embryogenesis and continues throughout life, contributing to the growth of the eye lens. Secondary lens fibers are specifically those cells that are newly differentiated and cover the old lens fiber core. This process also leads to the removal of light-obstructing cellular components, mainly nuclei and organelles, making these fibers transparent and ideal for their function. \nThe fibers carry out their primary function of light refraction via a high concentration of specialized proteins known as crystallins, which form a gradient of refractive index together with the cytoplasm. This index manipulation facilitates precise light focus onto the retina. Secondary lens fibers also contribute to the lens's shape and biomechanical properties through intercellular interactions, particularly at the sutures where the ends of the fibers meet. Any disruption to secondary lens fibers can lead to vision problems, including cataracts, which is the clouding of the lens resulting from the aggregation of crystallin proteins.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1016/B978-1-4377-1926-0.10005-0", xref="DOI:10.1016/j.biocel.2007.10.034", xref="DOI:10.1098/rstb.2010.0324", xref="DOI:10.1136/bmjophth-2020-000459", xref="https://www.sciencedirect.com/topics/immunology-and-microbiology/lens-fiber"} creation_date: 2010-09-07T10:53:39Z [Term] id: CL:0002226 name: non-nucleated secondary lens fiber def: "A secondary lens fiber cell that lacks a nucleus." [GOC:tfm] subset: human_subset subset: mouse_subset synonym: "non-nucleated secondary lens fibre" EXACT [] xref: FMA:67561 is_a: CL:0002225 ! secondary lens fiber relationship: RO:0002202 CL:0002227 ! develops from nucleated secondary lens fiber property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-09-07T11:15:23Z [Term] id: CL:0002227 name: nucleated secondary lens fiber def: "A secondary fiber cell that contains a nucleus." [GOC:tfm] subset: human_subset subset: mouse_subset synonym: "nucleated secondary lens fibre" EXACT [] xref: FMA:70949 is_a: CL:0002225 ! secondary lens fiber property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-09-07T11:15:26Z [Term] id: CL:0002228 name: primary lens fiber def: "An elongating cell that rapidly obliterates the lumen of the lens vesicle. Subsequently, differentiation of this cell type at the lens equator leads to the formation of secondary fiber cells that come to overlie the primary fibers." [GOC:tfm, PMID:10711704] subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "primary lens fibre" EXACT [] xref: FMA:70613 is_a: BFO:0000002 is_a: CL:0011004 ! lens fiber cell relationship: RO:0002202 CL:0002223 ! develops from anterior lens cell property_value: RO:0002175 NCBITaxon:9606 property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-09-07T11:19:01Z [Term] id: CL:0002229 name: light chief cell of parathyroid gland def: "A chief cell that is bigger than dark chief cells and has a larger and lighter nucleus and a cytoplasm with few granules." [GOC:tfm, ISBN:0721662544] subset: human_subset subset: mouse_subset xref: FMA:69079 is_a: CL:0000446 ! chief cell of parathyroid gland property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-09-07T11:46:54Z [Term] id: CL:0002231 name: epithelial cell of prostate alt_id: CL:1000295 alt_id: CL:1000408 def: "An epithelial cell of the prostate." [GOC:tfm] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "prostate epithelial cell" EXACT [] xref: FMA:256163 xref: FMA:66817 is_a: CL:0002076 {is_inferred="true"} ! endo-epithelial cell intersection_of: CL:0002076 ! endo-epithelial cell intersection_of: BFO:0000050 UBERON:0002367 ! part of prostate gland relationship: BFO:0000050 UBERON:0002367 ! part of prostate gland property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0002231" xsd:string {name="epithelial cell of prostate on CELLxGENE CellGuide"} property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 property_value: terms:description "Epithelial cells of the prostate, also known as prostatic epithelial cells, are specialized cells found in the prostate gland, which surrounds the male urethra beneath the bladder. They play a crucial role in forming the acini and ducts of the gland's structure. The prostate's epithelium has multiple layers, including basal, luminal, and neuroendocrine cells; the luminal layer is composed of columnar epithelial cells, and the basal layer is composed of cuboidal epithelial cells.\nProstatic epithelial cells primarily aid in the production and secretion of prostatic fluid, a critical component of semen. This fluid, which accounts for around 20-30% of semen volume, serves several key functions related to fertility. The prostatic fluid is alkaline in nature that aids in neutralizing acidic vaginal secretions, promoting the survival of sperm in the female reproductive tract. It also contains proteolytic enzymes that, upon ejaculation, lead to the liquefaction of semen, enhancing the motility of sperm. \nAdditionally, prostate epithelial cells are involved in the secretion of prostate-specific antigen (PSA), a kallikrein-like serine protease, which is a normal component of the seminal plasma further aids in semen liquefaction.\nProstatic epithelial cells are also linked to conditions like benign prostatic hyperplasia, which involves abnormal cell growth, and prostate cancer, which originates from prostatic epithelial cell transformations, especially in the peripheral zone. Consequently, these cells are key focal points in understanding and treating prostatic conditions and malignancies.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1016/j.celrep.2018.11.086", xref="DOI:10.1038/onc.2012.541", xref="DOI:10.1038/s41598-019-40820-2", xref="DOI:10.1159/000496289"} creation_date: 2010-09-07T01:49:29Z [Term] id: CL:0002232 name: epithelial cell of prostatic duct alt_id: CL:1000462 def: "An epithelial cell of prostatic duct." [GOC:tfm] subset: human_subset subset: mouse_subset synonym: "ductal epithelial cell of prostate" EXACT [FMA:74224] xref: FMA:74224 is_a: CL:0000072 {is_inferred="true"} ! non-branched duct epithelial cell is_a: CL:0002231 ! epithelial cell of prostate intersection_of: CL:0000072 ! non-branched duct epithelial cell intersection_of: BFO:0000050 UBERON:0002485 ! part of prostate duct relationship: BFO:0000050 UBERON:0002485 ! part of prostate duct property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-09-07T01:55:51Z [Term] id: CL:0002233 name: epithelial cell of prostatic acinus alt_id: CL:1000461 def: "An epithelial cell of the prostatic acinus." [GOC:tfm, PMCID:PMC2673349] subset: human_subset subset: mouse_subset synonym: "acinar epithelial cell of prostate" EXACT [FMA:74223] xref: FMA:74223 is_a: CL:0002231 {is_inferred="true"} ! epithelial cell of prostate intersection_of: CL:0002231 ! epithelial cell of prostate intersection_of: BFO:0000050 UBERON:0004179 ! part of prostate glandular acinus relationship: BFO:0000050 UBERON:0004179 ! part of prostate glandular acinus property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-09-07T01:55:53Z [Term] id: CL:0002234 name: basal cell of prostatic acinus alt_id: CL:1000464 def: "A cell of the basal layer of the epithelium in the prostatic acinus." [GOC:tfm] subset: human_subset subset: mouse_subset synonym: "basal epithelial cell of prostatic acinus" EXACT [FMA:74265] xref: FMA:74265 is_a: CL:0002233 ! epithelial cell of prostatic acinus is_a: CL:0002341 ! basal cell of prostate epithelium intersection_of: CL:0002341 ! basal cell of prostate epithelium intersection_of: BFO:0000050 UBERON:0004179 ! part of prostate glandular acinus property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-09-07T01:59:08Z [Term] id: CL:0002235 name: luminal cell of prostatic acinus def: "A cell of the luminal layer of the epithelium in the prostatic acinus." [GOC:tfm] subset: human_subset subset: mouse_subset xref: FMA:74266 is_a: CL:0002233 ! epithelial cell of prostatic acinus is_a: CL:0002340 ! luminal cell of prostate epithelium intersection_of: CL:0002340 ! luminal cell of prostate epithelium intersection_of: BFO:0000050 UBERON:0004179 ! part of prostate glandular acinus property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-09-07T01:59:10Z [Term] id: CL:0002236 name: basal epithelial cell of prostatic duct alt_id: CL:1000463 def: "A cell that constitutes the basal layer of epithelium in the prostatic duct." [GOC:tfm, PMID:15226377] subset: cellxgene_subset subset: human_subset subset: mouse_subset xref: FMA:74226 is_a: CL:0000068 ! duct epithelial cell is_a: CL:0002341 ! basal cell of prostate epithelium intersection_of: CL:0002341 ! basal cell of prostate epithelium intersection_of: BFO:0000050 UBERON:0002485 ! part of prostate duct relationship: BFO:0000050 UBERON:0002485 ! part of prostate duct property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0002236" xsd:string {name="basal epithelial cell of prostatic duct on CELLxGENE CellGuide"} property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 property_value: terms:description "Basal epithelial cells of the prostatic duct are unique cell types found within the prostate gland of mammals. The prostatic duct forms a significant part of the prostate's glandular architecture, facilitating the secretion and flow of prostatic fluid. These basal cells are positioned at the base of the prostatic epithelium, forming a layer beneath luminal cells and adjacent to the basement membrane. Functionally, they play a significant role in maintaining tissue homeostasis, managing secretory activities, and contributing to the overall biological functions of the prostate. \nThese basal epithelial cells exhibit a high degree of differentiation. Morphologically, they are characterized by their low columnar or cuboidal shape and exhibit less cytoplasm compared to luminal epithelial cells. A notable feature is their high nucleus-to-cytoplasm ratio and the presence of prominent nucleoli. On a molecular level, these cells are known to express certain distinct markers such as cytokeratin 5 (CK5) and p63, differentiating them from other prostatic cells. \nThe basal epithelial cells of the prostatic duct also serve as a reserve cell population for the regeneration of the prostate epithelium, particularly upon injury or disease, indicating their role in tissue repair and regrowth. Importantly, these cells are also considered as the cells-of-origin in prostate cancer due to their extended lifespan and genomic stability.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1002/stem.1094", xref="DOI:10.1016/B978-0-12-801238-3.64595-6", xref="DOI:10.1016/j.celrep.2018.11.086", xref="DOI:10.1242/dev.01384", xref="DOI:10.1309/AJCP5ZC4GQVNWTYR"} creation_date: 2010-09-07T01:59:12Z [Term] id: CL:0002237 name: luminal epithelial cell of prostatic duct def: "A cell that constitutes the luminal layer of epithelium of prostatic duct." [GOC:tfm] subset: human_subset subset: mouse_subset xref: FMA:74225 is_a: CL:0000068 ! duct epithelial cell is_a: CL:0002340 ! luminal cell of prostate epithelium intersection_of: CL:0002340 ! luminal cell of prostate epithelium intersection_of: BFO:0000050 UBERON:0002485 ! part of prostate duct relationship: BFO:0000050 UBERON:0002485 ! part of prostate duct property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-09-07T01:59:16Z [Term] id: CL:0002238 name: male gonocyte def: "A primordial germ cell that is destined to become a male germ cell." [GOC:tfm] subset: human_subset subset: mouse_subset synonym: "male primordial germ cell" EXACT [] synonym: "testis primordial germ cell" EXACT [VHOG:0000662] xref: EHDAA2:0001053 xref: EMAPA:18686 xref: FMA:84771 xref: VHOG:0000662 is_a: CL:0000670 ! primordial germ cell relationship: BFO:0000050 UBERON:0000473 ! part of testis property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-09-07T02:11:13Z [Term] id: CL:0002239 name: ooblast def: "A primordial cell from which an oocyte (ovum) ultimately is developed." [GOC:tfm] subset: human_subset subset: mouse_subset synonym: "ovary primordial germ cell" EXACT [VHOG:0000661] synonym: "ovigerm" EXACT [FMA:84772] xref: EHDAA2:0000505 xref: EMAPA:17965 xref: FMA:84772 xref: ISBN:0721662544 xref: VHOG:0000661 is_a: CL:0000255 ! eukaryotic cell is_a: CL:0000670 ! primordial germ cell relationship: BFO:0000050 UBERON:0000992 ! part of ovary property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-09-07T02:11:16Z [Term] id: CL:0002240 name: marrow fibroblast def: "A fibroblast in the bone marrow." [GOC:tfm] subset: human_subset subset: mouse_subset xref: FMA:84377 is_a: CL:0000057 ! fibroblast is_a: CL:0010001 ! stromal cell of bone marrow intersection_of: CL:0000057 ! fibroblast intersection_of: BFO:0000050 UBERON:0002371 ! part of bone marrow property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-09-07T02:25:18Z [Term] id: CL:0002241 name: pulmonary interstitial fibroblast def: "A fibroblasts found in interstitial spaces in the pulmonary tract. Greater numbers of these cells are found in idiopathic pulmonary fibrosis." [GOC:tfm] comment: The marker set DPT, APOD can identify the Human cell type pulmonary interstitial fibroblast in the lung with a confidence of 0.58 (NS-Forest FBeta value). {xref="https://doi.org/10.5281/zenodo.11165918"} subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "pulmonary myofibroblast" EXACT [] synonym: "pulmonary septal cell" EXACT [] xref: FMA:84467 is_a: CL:0000057 {is_inferred="true"} ! fibroblast is_a: CL:4030031 ! interstitial cell intersection_of: CL:0000057 ! fibroblast intersection_of: BFO:0000050 UBERON:0001004 ! part of respiratory system intersection_of: BFO:0000050 UBERON:0005169 ! part of interstitial tissue relationship: BFO:0000050 UBERON:0001004 ! part of respiratory system relationship: RO:0015004 CLM:1000046 ! has characterizing marker set NS forest marker set of pulmonary interstitial fibroblast (Human lung). property_value: RO:0002175 NCBITaxon:9606 property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0002241" xsd:string {name="pulmonary interstitial fibroblast on CELLxGENE CellGuide"} property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 property_value: terms:description "Pulmonary interstitial fibroblasts, or lung fibroblasts, are a specific type of cell located within the lungs. They are predominantly located in the connective tissue or interstitial space of the lung that is in close proximity to the alveolar epithelium and pulmonary capillaries. These cells play a crucial role in maintaining lung structure and function through the synthesis and remodeling of the extracellular matrix, which provides structural support to the lung tissues.\nThese cells ensure effective gas exchange by providing a scaffold for the epithelial structure. In addition to providing support, the extracellular matrix acts as a binding site for various molecules that can directly influence cell behavior and the local microenvironment. Fibroblasts not only secrete the extracellular matrix themselves but also have the capacity to remodel the matrix by producing matrix metalloproteinases (MMPs). This ability of synthesis and degradation makes fibroblasts essential for normal lung homeostasis and repair following lung injury.\nUnder pathological conditions such as pulmonary fibrosis, the function of pulmonary interstitial fibroblasts becomes deregulated. They become overly active and produce excess extracellular matrix, notably collagen, resulting in the thickening and stiffening of lung tissues that compromise its function. Furthermore, these cells can transform into myofibroblasts, cells that are more active in producing matrix proteins and contribute to scar formation or fibrosis. Understanding the biology and regulation of pulmonary interstitial fibroblasts is thus essential for devising therapeutic strategies for diseases characterized by abnormal tissue remodeling and fibrosis, such as idiopathic pulmonary fibrosis and chronic obstructive pulmonary disease (COPD).\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1002/sctm.20-0526", xref="DOI:10.1016/j.heliyon.2023.e19428", xref="DOI:10.1164/rccm.200706-929OC", xref="DOI:10.1513/AnnalsATS.201605-341AW", xref="DOI:10.3390/ijms20061461"} creation_date: 2010-09-07T02:29:38Z [Term] id: CL:0002242 name: nucleate cell def: "A cell containing at least one nucleus." [GOC:tfm] subset: human_subset subset: mouse_subset xref: FMA:67513 is_a: CL:0000000 ! cell intersection_of: CL:0000000 ! cell intersection_of: RO:0000053 PATO:0002505 ! has characteristic nucleated relationship: RO:0000053 PATO:0002505 ! has characteristic nucleated property_value: skos:prefLabel "nucleate cell" xsd:string property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-09-07T03:32:33Z [Term] id: CL:0002243 name: smooth muscle cell of sphincter of pupil def: "A circular smooth muscle cell of the iris, innervated by the ciliary nerves (parasympathetic), and acting to contract the pupil. This muscle cell derives from neuroectoderm. This smooth muscle cell results from transformation of epithelial cells to smooth muscle cells." [GOC:tfm, ISBN:0721662544, ISBN:0721694128] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "smooth muscle fiber of sphincter of pupil" EXACT [] synonym: "smooth muscle fibre of sphincter of pupil" RELATED [] xref: FMA:70611 is_a: CL:0000358 {is_inferred="true"} ! sphincter associated smooth muscle cell intersection_of: CL:0000192 ! smooth muscle cell intersection_of: BFO:0000050 UBERON:0001607 ! part of sphincter pupillae relationship: BFO:0000050 UBERON:0001607 ! part of sphincter pupillae relationship: RO:0002202 CL:0000133 ! develops from neurectodermal cell property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0002243" xsd:string {name="smooth muscle cell of sphincter of pupil on CELLxGENE CellGuide"} property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 property_value: terms:description "The smooth muscle cell of sphincter of pupil is a specialized cell type typically found within the eye, more specifically within the sphincter muscle of the iris. \nThese cells can constrict and dilate in response to light signals, tightly regulating the amount of light reaching the retina. Contraction narrows the pupil in bright conditions (pupillary constriction), protecting the retina from excessive light. In low light, relaxation allows dilation (pupillary dilation), enhancing visual perception in dim conditions.\nThese cells are also innervated by parasympathetic fibers from the oculomotor nerve. Light signals to the Edinger-Westphal nucleus stimulate the release of acetylcholine, contracting the cells. On the contrary, sympathetic stimulation induces relaxation. This precise control plays a crucial role in optimizing visual function, highlighting their essential role in vision biology.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="https://www.ncbi.nlm.nih.gov/books/NBK532252/", xref="https://www.ncbi.nlm.nih.gov/books/NBK537180/", xref="https://www.sciencedirect.com/topics/neuroscience/iris-dilator-muscle", xref="https://www.sciencedirect.com/topics/neuroscience/iris-sphincter-muscle"} creation_date: 2010-09-08T08:53:42Z [Term] id: CL:0002244 name: squamous cell of ectocervix def: "A stratified squamous epithelial cell located in the ectocervix." [doi:/10.1016/j.autneu.2015.04.008, GOC:tfm, http://www.bu.edu/histology/p/19404loa.htm, PMID:32644501] subset: human_subset subset: mouse_subset synonym: "ectocervical squamous cell" EXACT [] xref: FMA:86483 is_a: CL:1001575 ! uterine cervix squamous cell intersection_of: CL:0000076 ! squamous epithelial cell intersection_of: BFO:0000050 UBERON:0012251 ! part of ectocervical epithelium relationship: BFO:0000050 UBERON:0012251 ! part of ectocervical epithelium property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-09-08T09:12:23Z [Term] id: CL:0002245 name: obsolete null lymphocyte def: "OBSOLETE: A lymphocyte that lacks T or B cell surface markers." [GOC:tfm, ISBN:068340007X] xref: FMA:83601 property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 is_obsolete: true creation_date: 2010-09-07T03:43:42Z [Term] id: CL:0002246 name: peripheral blood stem cell def: "A hematopoeitic stem cell found in the blood. Normally found in very limited numbers in the peripheral circulation (less than 0.1% of all nucleated cells)." [GOC:tfm] subset: human_subset subset: mouse_subset synonym: "PBSC" EXACT [] xref: BTO:0002669 xref: FMA:86711 xref: MESH:D000072916 is_a: CL:0000037 {is_inferred="true"} ! hematopoietic stem cell is_a: CL:0000080 ! circulating cell intersection_of: CL:0000037 ! hematopoietic stem cell intersection_of: BFO:0000050 UBERON:0000178 ! part of blood relationship: BFO:0000050 UBERON:0000178 ! part of blood property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-09-07T03:57:09Z [Term] id: CL:0002247 name: pleural macrophage def: "A tissue macrophage that is in the pleural space." [GOC:tfm] subset: human_subset subset: mouse_subset xref: FMA:83024 is_a: CL:0000864 ! tissue-resident macrophage property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-09-07T04:16:43Z [Term] id: CL:0002248 name: pluripotent stem cell def: "A pluripotent stem cell has the ability to form cells from all three germ layers (ectoderm, mesoderm, and endoderm). However, unlike totipotent stem cells, they cell can not generate all the cells of the whole organism such as placenta." [GOC:tfm, PMID:19343304] subset: cellxgene_subset subset: human_subset subset: mouse_subset xref: FMA:70570 xref: MESH:D039904 is_a: CL:0000723 ! somatic stem cell property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-09-07T04:26:06Z [Term] id: CL:0002249 name: primitive cardiac myocyte def: "A stem cell that can differentiate into a cardiac myocyte." [GOC:tfm, PMID:16938308] subset: human_subset subset: mouse_subset xref: FMA:75620 is_a: CL:0000035 ! single fate stem cell is_a: CL:0002078 ! meso-epithelial cell property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-09-07T04:40:32Z [Term] id: CL:0002250 name: intestinal crypt stem cell def: "A stem cell located in epithelium the based of the crypt of Lieberkuhn. Division of these cells serve both to maintain the stem cell population and produce the transit amplifying cells that are all precursors of all cell types that populate the intestinal epithelium." [GOC:tfm, ISBN:0517223651] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "stem cell of intestinal crypt of Lieberkuhn" EXACT [] xref: FMA:63379 is_a: CL:0000048 ! multi fate stem cell is_a: CL:0002563 ! intestinal epithelial cell intersection_of: CL:0000034 ! stem cell intersection_of: BFO:0000050 UBERON:0001983 ! part of crypt of Lieberkuhn relationship: BFO:0000050 UBERON:0001983 ! part of crypt of Lieberkuhn property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0002250" xsd:string {name="intestinal crypt stem cell on CELLxGENE CellGuide"} property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 property_value: terms:description "Intestinal crypt stem cells, also known as crypt base columnar cells, are a unique type of cell, characterized by the highly specific marker LGR5, found in the intestinal epithelium. Situated at the bottom of the minute pockets known as crypts of Lieberkühn, these are undifferentiated cells that have the ability to perpetually self-renew, as well as differentiate into various other cell types that constitute the epithelial lining of the intestine. \nThe fundamental role of intestinal crypt stem cells is to provide a constant supply of new cells to maintain the cellular turnover of the intestinal epithelium, a tissue known for rapid self-renewal. These stem cells are nurtured and protected by specialized epithelial and mesenchymal cells, and together constitute the intestinal stem cell niche. \nAn important function of intestinal crypt stem cells is to sustain the balance between cell division and programmed cell death, called apoptosis, to ensure the integrity of the intestinal lining. Given their active proliferation rate, these stem cells initiate the creation of diverse differentiated cell types, including enterocytes (the primary absorptive cells in the intestinal lumen), goblet cells (that produce mucus to protect the epithelial layer), enteroendocrine cells (involved in producing gastrointestinal hormones), and Paneth cells (involved in secreting antimicrobial peptides). This diversity in output regulates the physiological activities of the gut ranging from nutrient absorption, hormone secretion, bacterial balance, to immunity.\nResearch studies suggest that dysregulation in intestinal crypt stem cell proliferation and differentiation is associated with several intestinal disorders including intestinal cancer, and various enteropathies.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1016/j.cell.2013.07.004", xref="DOI:10.1038/s41575-018-0081-y", xref="DOI:10.1038/s41580-020-0278-0", xref="DOI:10.1101/gad.1674008", xref="DOI:10.1111/j.1365-2184.2009.00642.x"} creation_date: 2010-09-08T09:21:22Z [Term] id: CL:0002251 name: epithelial cell of alimentary canal def: "An epithelial cell of the musculomembranous digestive tube extending from the mouth to the anus." [GOC:tfm, ISBN:0721662544] subset: human_subset subset: mouse_subset is_a: CL:0002076 ! endo-epithelial cell intersection_of: CL:0000066 ! epithelial cell intersection_of: BFO:0000050 UBERON:0003929 ! part of digestive tract epithelium relationship: BFO:0000050 UBERON:0003929 ! part of digestive tract epithelium property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-09-08T09:26:53Z [Term] id: CL:0002252 name: epithelial cell of esophagus alt_id: CL:1000402 def: "An epithelial cell of the lining of the esophagus." [GOC:tfm] subset: cellxgene_subset subset: human_subset subset: mouse_subset xref: FMA:63071 xref: ZFA:0009400 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0002251 {is_inferred="true"} ! epithelial cell of alimentary canal intersection_of: CL:0000066 ! epithelial cell intersection_of: BFO:0000050 UBERON:0001976 ! part of epithelium of esophagus relationship: BFO:0000050 UBERON:0001976 ! part of epithelium of esophagus property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-09-08T09:28:20Z [Term] id: CL:0002253 name: epithelial cell of large intestine alt_id: CL:1000292 def: "An epithelial cell of the lining of the large intestine." [GOC:tfm] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "epithelial cell of colon" RELATED [] xref: BTO:0004297 xref: FMA:256157 is_a: CL:0002563 {is_inferred="true"} ! intestinal epithelial cell intersection_of: CL:0002563 ! intestinal epithelial cell intersection_of: BFO:0000050 UBERON:0000059 ! part of large intestine relationship: BFO:0000050 UBERON:0001278 ! part of epithelium of large intestine property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-09-08T09:28:22Z [Term] id: CL:0002254 name: epithelial cell of small intestine alt_id: CL:1000293 def: "An epithelial cell of the lining of the small intestine." [GOC:tfm] subset: cellxgene_subset subset: human_subset subset: mouse_subset xref: FMA:256159 is_a: CL:0002563 {is_inferred="true"} ! intestinal epithelial cell intersection_of: CL:0002563 ! intestinal epithelial cell intersection_of: BFO:0000050 UBERON:0002108 ! part of small intestine relationship: BFO:0000050 UBERON:0002108 ! part of small intestine property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-09-08T09:41:46Z [Term] id: CL:0002255 name: stromal cell of endometrium def: "A stromal cell of the endometrium, characterized by its fibroblast-like morphology, regenerative capacity, and ability to undergo decidualization. It differentiates into a decidual stromal cell during pregnancy, essential for embryo implantation and maintenance. This cell is involved in tissue proliferation, remodeling, and breakdown, responding to hormonal changes, particularly estrogen and progesterone." [https://doi.org/10.1038/s41591-020-1040-z, PMID:11331626, PMID:30013421, PMID:30309298, PMID:31907034, Wikipedia:Decidualization] subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "endometrial stromal cell" EXACT [] synonym: "endometrial stromal fibroblast" EXACT [PMID:30309298] synonym: "stromal cell of uterus" BROAD [] xref: CALOHA:TS-1266 xref: FMA:86490 is_a: CL:0000499 ! stromal cell intersection_of: CL:0000499 ! stromal cell intersection_of: BFO:0000050 UBERON:0002337 ! part of endometrial stroma relationship: BFO:0000050 UBERON:0002337 ! part of endometrial stroma relationship: RO:0002215 GO:0046697 ! capable of decidualization relationship: RO:0002388 CL:2000002 ! has potential to directly develop into decidual cell property_value: RO:0002175 NCBITaxon:9606 property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-09-08T09:50:04Z [Term] id: CL:0002256 name: supporting cell of carotid body def: "A supportive cell that has characteristics of glial cell. Processes of this cell envelope the junctions between glomus cells and nerve endings." [GOC:tfm, http://www.copewithcytokines.de/cope.cgi?key=glomus%20cells, PMID:8985136] subset: human_subset subset: mouse_subset synonym: "carotid body sustentacular cell" EXACT [] xref: FMA:84188 is_a: CL:0000630 ! supporting cell is_a: CL:0000710 ! neurecto-epithelial cell property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-09-08T10:34:45Z [Term] id: CL:0002257 name: epithelial cell of thyroid gland alt_id: CL:1000297 def: "An epithelial cell of thyroid gland." [GOC:tfm] subset: cellxgene_subset subset: human_subset subset: mouse_subset xref: FMA:256167 xref: MESH:D000072637 is_a: CL:0000150 ! glandular secretory epithelial cell is_a: CL:0002076 ! endo-epithelial cell intersection_of: CL:0000066 ! epithelial cell intersection_of: BFO:0000050 UBERON:0002046 ! part of thyroid gland relationship: BFO:0000050 UBERON:0002046 ! part of thyroid gland property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-09-08T01:46:51Z [Term] id: CL:0002258 name: thyroid follicular cell def: "An epithelial cell that is part of the thyroid follicle epithelium, with a shape that ranges from squamous when inactive to cuboidal or columnar when active, reflecting its hormonal activity. Its apical surface is lined with microvilli projecting into the colloid-filled lumen, where it synthesizes, stores, and secretes the thyroid hormones thyroxine (T4) and triiodothyronine (T3), releasing them into the bloodstream in response to thyroid-stimulating hormone (TSH)." [GOC:tfm, ISBN:0517223651, PMID:31869123] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "follicular cell of thyroid gland" EXACT [] synonym: "principal cell of thyroid gland" EXACT [] synonym: "thyroid gland follicular cell" EXACT [] synonym: "thyroid hormone secreting cell" EXACT [] xref: BTO:0003736 xref: CALOHA:TS-1285 xref: FMA:68782 is_a: CL:0000163 ! endocrine cell is_a: CL:0000167 ! peptide hormone secreting cell is_a: CL:0002257 ! epithelial cell of thyroid gland relationship: BFO:0000050 UBERON:0012363 ! part of thyroid follicle epithelium relationship: BFO:0000051 GO:0005902 ! has part microvillus property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 property_value: terms:contributor https://orcid.org/0009-0000-8480-9277 creation_date: 2010-09-08T01:50:08Z [Term] id: CL:0002259 name: neuroepithelial stem cell def: "The stem cell from which glial precursor cell arises from." [GOC:tfm, PMID:11687496] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "totipotent neuroepithelial stem cell" NARROW [] xref: FMA:87171 is_a: CL:0000723 ! somatic stem cell property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-09-08T02:14:14Z [Term] id: CL:0002260 name: epithelial cell of parathyroid gland alt_id: CL:1000429 def: "An epithelial cell of the parathyroid gland." [GOC:tfm] subset: cellxgene_subset subset: human_subset subset: mouse_subset xref: FMA:70547 is_a: CL:0002076 ! endo-epithelial cell intersection_of: CL:0000066 ! epithelial cell intersection_of: BFO:0000050 UBERON:0001132 ! part of parathyroid gland relationship: BFO:0000050 UBERON:0001132 ! part of parathyroid gland property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-09-08T02:29:38Z [Term] id: CL:0002261 name: endothelial cell of viscerocranial mucosa alt_id: CL:1000446 def: "An endothelial cell found in the mucosa associated with the facial skeleton." [GOC:tfm, ISBN:0618947256] subset: human_subset subset: mouse_subset xref: FMA:70627 is_a: CL:0002076 ! endo-epithelial cell property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-09-14T10:40:12Z [Term] id: CL:0002262 name: endothelial cell of sinusoid alt_id: CL:1000403 def: "An endothelial cell that lines any of the venous cavities through which blood passes in various glands and organs such as the spleen and liver." [GOC:tfm, ISBN:0618947256] subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset xref: FMA:63134 is_a: CL:0000071 ! blood vessel endothelial cell intersection_of: CL:0000115 ! endothelial cell intersection_of: BFO:0000050 UBERON:0003909 ! part of sinusoid relationship: BFO:0000050 UBERON:0003909 ! part of sinusoid property_value: RO:0002175 NCBITaxon:9606 property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0002262" xsd:string {name="endothelial cell of sinusoid on CELLxGENE CellGuide"} property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 property_value: terms:description "Endothelial cells of sinusoids, often referred to as sinusoidal endothelial cells (SECs), are a specialized type of endothelial cell that primarily reside in the capillaries of the liver, spleen, and bone marrow. These cells form the innermost monolayer of the sinusoidal blood vessels, also known as sinusoids, that mediate the exchange of nutrients, metabolites, and waste materials between the blood and the surrounding organ tissue. SECs possess distinctive morphological features including a large, flattened shape, an abundance of fenestrations or pores, and the lack of a continuous basement membrane. These structural characteristics distinguish sinusoidal endothelial cells from other, more regularly structured endothelial cells in the body.\nDue to their special fenestrated structure, SECs facilitate the exchange of macromolecules, like lipoproteins and hyaluronan, between plasma and the surrounding organ parenchymal cells. These fenestrations act like sieves, allowing the passage of substances based on their size and charge. It's noteworthy that the permeability characteristics of SECs can be regulated dynamically according to the body's homeostatic needs. \nBeyond their key role in exchange mechanisms, endothelial cells of sinusoids are involved in several other functions. In the liver, for example, they help in the removal and endocytic degradation of waste macromolecules, immune response, and regulation of liver regeneration. They also participate in the formation and remodeling of blood vessels, a process known as angiogenesis. Additionally, in recent years, it has been discovered that these cells may have a role in disease conditions like cirrhosis and liver cancer.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1007/s10456-021-09780-y", xref="DOI:10.1016/j.jhep.2016.07.009", xref="DOI:10.1038/s41575-018-0020-y", xref="DOI:10.1038/s41598-020-57652-0", xref="DOI:10.1186/1476-5926-1-1"} creation_date: 2010-09-14T10:57:26Z [Term] id: CL:0002263 name: transitional cell of parathyroid gland def: "One of three types of epithelial cells that populate the parathyroid gland; cytological characteristics intermediate between those of the chief cell and of the oxyphil cell. Because only one hormone is produced, the three cell forms are widely believed to be different phases in the life cycle of a single cell type, with the chief cell being its physiologically active stage." [GOC:tfm, ISBN:0412046911] subset: human_subset subset: mouse_subset xref: FMA:69324 is_a: CL:0002260 ! epithelial cell of parathyroid gland property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-09-08T02:33:50Z [Term] id: CL:0002264 name: type A cell of stomach def: "A type of enteroendocrine cell found in the stomach that secretes glucagon." [GOC:tfm] subset: human_subset subset: mouse_subset xref: FMA:83411 is_a: CL:0002067 ! type A enteroendocrine cell is_a: CL:1001517 ! stomach enteroendocrine cell intersection_of: CL:0002067 ! type A enteroendocrine cell intersection_of: BFO:0000050 UBERON:0001276 ! part of epithelium of stomach property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-09-10T10:54:42Z [Term] id: CL:0002265 name: type D cell of colon def: "A D cell located in the colon." [GOC:tfm] subset: human_subset subset: mouse_subset synonym: "colon D-cell" EXACT [] synonym: "colonic delta cell" EXACT [] synonym: "delta cell of colon" EXACT [] xref: FMA:268744 is_a: CL:0000502 ! type D enteroendocrine cell is_a: CL:0009042 ! enteroendocrine cell of colon is_a: CL:1001588 ! colon glandular cell intersection_of: CL:0000502 ! type D enteroendocrine cell intersection_of: BFO:0000050 UBERON:0001155 ! part of colon property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-09-10T11:37:35Z [Term] id: CL:0002266 name: type D cell of small intestine def: "A type D cell of the small intestine." [GOC:tfm] subset: human_subset subset: mouse_subset synonym: "delta cell of small intestine" EXACT [] synonym: "small intestine D-cell" EXACT [] synonym: "small intestine delta cell" EXACT [] xref: FMA:268736 is_a: CL:0000502 ! type D enteroendocrine cell is_a: CL:0009006 ! enteroendocrine cell of small intestine intersection_of: CL:0000502 ! type D enteroendocrine cell intersection_of: BFO:0000050 UBERON:0002108 ! part of small intestine property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-09-10T01:34:22Z [Term] id: CL:0002267 name: type D cell of stomach def: "A type D cell found in the stomach." [GOC:tfm] subset: human_subset subset: mouse_subset synonym: "delta cell of stomach" EXACT [] synonym: "stomach D-cell" EXACT [] synonym: "stomach delta cell" EXACT [] xref: FMA:83410 is_a: CL:0000502 ! type D enteroendocrine cell is_a: CL:0002659 ! glandular epithelial cell of stomach is_a: CL:1000222 ! stomach neuroendocrine cell intersection_of: CL:0000502 ! type D enteroendocrine cell intersection_of: BFO:0000050 UBERON:0001276 ! part of epithelium of stomach property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-09-10T01:36:03Z [Term] id: CL:0002268 name: P/D1 enteroendocrine cell def: "An enteroendocrine cell that stores and secretes Ghrelin." [GOC:tfm, ISBN:0517223651, PMID:15153415] subset: cellxgene_subset subset: human_subset subset: mouse_subset xref: FMA:63418 is_a: CL:0000164 ! enteroendocrine cell is_a: CL:0002269 ! vasoactive intestinal peptide secreting cell property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-09-10T01:47:45Z [Term] id: CL:0002269 name: vasoactive intestinal peptide secreting cell def: "An endocrine cell that secretes vasoactive intestinal peptide." [GOC:tfm] subset: human_subset subset: mouse_subset is_a: CL:0000167 ! peptide hormone secreting cell property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-09-10T01:52:20Z [Term] id: CL:0002270 name: type EC2 enteroendocrine cell def: "A type EC enteroendocrine cell in the duodenum and jejunum that stores and secretes motilin and 5-hydroxytryptamine." [GOC:tfm, ISBN:0517223651, PMID:15153415] subset: human_subset subset: mouse_subset synonym: "Mo enteroendocrine cell" BROAD [] xref: FMA:62941 is_a: CL:0000577 ! type EC enteroendocrine cell is_a: CL:0002272 ! motilin secreting cell is_a: CL:1001516 ! intestinal enteroendocrine cell property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-09-10T02:13:47Z [Term] id: CL:0002271 name: type EC1 enteroendocrine cell def: "A type EC enteredocrine cell in the intestines that stores and secretes substance P and 5-hydroxytryptamine." [GOC:tfm, ISBN:0517223651] subset: human_subset subset: mouse_subset xref: FMA:62940 is_a: CL:0000505 ! substance P secreting cell is_a: CL:0000577 ! type EC enteroendocrine cell is_a: CL:1001516 ! intestinal enteroendocrine cell property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-09-10T02:13:49Z [Term] id: CL:0002272 name: motilin secreting cell def: "A cell that secretes motilin, a gastric hormone that at low pH inhibits gastric motor activity, whereas at high pH has a stimulating effect." [GOC:tfm, MESH:D009037] subset: human_subset subset: mouse_subset is_a: CL:0000167 ! peptide hormone secreting cell property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-09-10T02:31:13Z [Term] id: CL:0002273 name: type ECL enteroendocrine cell def: "A type EC enteroendocrine cell type that is numerous in the fundus of the stomach; stores 5-hydroxytryptamine and histamine." [GOC:tfm, ISBN:0517223651, PMID:15153415] subset: human_subset subset: mouse_subset xref: FMA:63208 is_a: CL:0000577 ! type EC enteroendocrine cell is_a: CL:0002274 ! histamine secreting cell property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-09-10T02:35:17Z [Term] id: CL:0002274 name: histamine secreting cell def: "A cell type that secretes histamine." [GOC:tfm] subset: human_subset subset: mouse_subset is_a: CL:0000457 ! biogenic amine secreting cell intersection_of: CL:0000151 ! secretory cell intersection_of: RO:0002215 GO:0001821 ! capable of histamine secretion relationship: RO:0002215 GO:0001821 ! capable of histamine secretion property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-09-10T03:04:42Z [Term] id: CL:0002275 name: pancreatic PP cell def: "A PP cell located in the islets of the pancreas." [GOC:tfm] comment: The term PP cell of pancreatic acinus was obsoleted due to a lack of evidence, making PP cell of pancreatic islets synonymous with pancreatic PP cell. subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "pancreatic polypeptide-secreting cell" EXACT [] synonym: "PP cell of pancreatic islet" EXACT [] synonym: "PP-cell of pancreatic islet" EXACT [] xref: BTO:0000805 xref: FMA:70588 xref: MESH:D050418 xref: ZFA:0005742 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000696 ! PP cell is_a: CL:0008024 ! pancreatic endocrine cell intersection_of: CL:0000696 ! PP cell intersection_of: BFO:0000050 UBERON:0000006 ! part of islet of Langerhans intersection_of: BFO:0000050 UBERON:0001264 ! part of pancreas relationship: BFO:0000050 UBERON:0000006 ! part of islet of Langerhans property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/2d-ftu/pancreas-islets-langerhans/v1.2/assets/2d-ftu-pancreas-islets-langerhans.png" xsd:string {terms:licence="http://creativecommons.org/licenses/by/4.0/", xref="doi:10.48539/HBM637.SFSW.654"} property_value: RO:0002175 NCBITaxon:9606 property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0002275" xsd:string {name="pancreatic PP cell on CELLxGENE CellGuide"} property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 property_value: terms:description "Pancreatic polypeptide (PP) cells (also called F or gamma cells) are unique endocrine cells located within the Islets of Langerhans in the pancreas. PP cells are one of the rarer pancreatic cell types and are more prevalent in the head and neck of the pancreas. They are critical in normal pancreatic physiological functions and are involved in the development of pancreatic endocrine disorders.\nThe primary function of PP cells is the production and secretion of the pancreatic polypeptide hormone (PP). This hormone plays a crucial role in several gastrointestinal functions and metabolic responses. The release of the PP hormone is stimulated after eating, especially in protein-rich meals, leading to it being present in large amounts during digestion. The fundamental role of PP is to self-regulate pancreatic secretion activities ensuring its exocrine and endocrine functions are under control.\nThe pancreatic polypeptide hormone from PP cells also aids in adapting to low physical activity and fasting by reducing the production of insulin and glucagon and inhibiting the hepatic glucose production. Additionally, this hormone influences gut motility by slowing down the gastric emptying and reducing small intestinal transit, thereby controlling the pace at which nutritional substances are absorbed. Because of these functions, any malfunction or irregularity in PP cells can result in various disorders such as diabetes and pancreatic diseases.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1016/B978-0-12-819402-7.00001-2", xref="DOI:10.1016/B978-012369442-3/50154-9", xref="DOI:10.1016/j.mce.2015.06.028", xref="DOI:10.1038/s42255-019-0148-2", xref="DOI:10.3389/fendo.2023.1192311"} creation_date: 2010-09-10T03:30:31Z [Term] id: CL:0002276 name: obsolete PP cell of pancreatic acinus def: "OBSOLETE: A PP cell located in the pancreatic acinus. Obsoleted due to a lack of published evidence that this cell type is actually found in the pancreatic acinus." [GOC:tfm] synonym: "type F cell of pancreatic acinus" EXACT [] xref: FMA:85400 property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 is_obsolete: true creation_date: 2010-09-10T03:30:33Z [Term] id: CL:0002277 name: type I enteroendocrine cell def: "An enteroendocrine cell commonest in the duodenum and jejunum, rare in ileum, that secretes cholecystokinin. This cell type is involved in the regulation of digestive enzymes and bile." [GOC:tfm] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "CCK cell" EXACT [] xref: FMA:62937 is_a: CL:0000167 ! peptide hormone secreting cell is_a: CL:0009006 ! enteroendocrine cell of small intestine property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-09-10T03:44:36Z [Term] id: CL:0002278 name: GIP cell def: "An enteroendocrine cell of duodenum and jejunum that produces gastric inhibitory peptide." [GOC:tfm] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "type K enteroendocrine cell" EXACT [] xref: FMA:62942 is_a: CL:0000167 ! peptide hormone secreting cell is_a: CL:0009006 ! enteroendocrine cell of small intestine property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-09-10T03:51:47Z [Term] id: CL:0002279 name: type L enteroendocrine cell def: "A enteroendocrine cell type that is numerous in ileum, present in jejunum and large intestine, few in duodenum. This cell type produces glucagon-like immunoreactants (glicentin, glucagon-37, glucagon-29, GLP-1 and -2) and PYY." [ISBN:0517223651, PMID:15153415] subset: cellxgene_subset subset: human_subset subset: mouse_subset xref: FMA:62944 is_a: CL:0000167 ! peptide hormone secreting cell is_a: CL:1001516 ! intestinal enteroendocrine cell property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0002279" xsd:string {name="type L enteroendocrine cell on CELLxGENE CellGuide"} property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 property_value: terms:description "The type L enteroendocrine cell, also known as L-cell, is an integral part of the digestive system found in the intestine, primarily identified in the ileum and colon. These cells are distinguished among other cell types primarily because of their role in the secretion of glucagon-like peptide-1 (GLP-1) and peptide YY (PYY). Both peptides are essential for maintaining the body's energy homeostasis and the normal functioning of the gastrointestinal tract.\nIn response to the ingestion of food, type L enteroendrocrine cells secrete GLP-1, a potent hormone that stimulates insulin secretion, lowers glucagon secretion, slows gastric emptying, enhances satiety, and has the potential to promote proliferation of type B pancreatic cells and improve their function.\nL-cells also secrete peptide YY (PYY), which plays a pivotal role in controlling appetite. Postprandially secreted into the bloodstream, PYY functions by decreasing appetite and food intake, thereby contributing to long-term energy balance. PYY can centralize the regulation of appetite via the hypothalamus.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1016/j.cmet.2008.11.002", xref="DOI:10.1038/ncpendmet0318", xref="DOI:10.1038/nrendo.2011.77", xref="DOI:10.1042/CS20150154", xref="DOI:10.1111/j.1749-6632.2003.tb03176.x"} creation_date: 2010-09-10T03:59:09Z [Term] id: CL:0002280 name: type N enteroendocrine cell def: "An enteroendocrine cell found in the ileum and jejunum that produces neurotensin." [GOC:tfm] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "N cell" EXACT [] xref: FMA:62943 is_a: CL:0000167 ! peptide hormone secreting cell is_a: CL:0009006 ! enteroendocrine cell of small intestine property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-09-10T04:08:29Z [Term] id: CL:0002281 name: type S enteroendocrine cell def: "Scattered in duodenojejunal mucosa, this enteroendocrine cell secretes secretin and serotonin." [GOC:tfm, PMID:15153415] subset: human_subset subset: mouse_subset xref: FMA:62936 is_a: CL:0000167 ! peptide hormone secreting cell is_a: CL:0000458 ! serotonin secreting cell is_a: CL:0009006 ! enteroendocrine cell of small intestine property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-09-10T04:44:46Z [Term] id: CL:0002282 name: type TG enteroendocrine cell def: "An enteroendocrine cell which produces a gastrin- and cholecystokinin-like peptide. The apical microvilli-rich plasma membrane is in open contact with the small intestine mucosa. This cell type is devoid of gastrin-17 but contains other fragments of the gastrin polypeptide." [DOI:10.1007/978-3-211-99390-3, GOC:tfm, PMID:7013499] subset: human_subset subset: mouse_subset xref: FMA:63421 is_a: CL:0000164 ! enteroendocrine cell is_a: CL:0000509 ! gastrin secreting cell property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-09-13T09:48:34Z [Term] id: CL:0002283 name: ecto-epithelial cell of viscerocranial mucosa alt_id: CL:1000440 def: "An epithelial cell of the mucosa associated with facial skeleton." [GOC:tfm, ISBN:0323052908] subset: human_subset subset: mouse_subset xref: FMA:70581 is_a: CL:0002159 ! general ecto-epithelial cell property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-09-14T11:04:02Z [Term] id: CL:0002284 name: type X enteroendocrine cell def: "An enteroendocrine cell found in the fundus and pylorus; this cell type has dense round secretory granules that contain ghrelin." [GOC:tfm, PMID:20616512] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "A-like" EXACT [] synonym: "X/A-like" EXACT [] xref: FMA:63209 is_a: CL:0000164 ! enteroendocrine cell is_a: CL:0005018 ! ghrelin secreting cell property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-09-13T10:12:12Z [Term] id: CL:0002285 name: type III taste bud cell def: "A taste receptor cell that is characterized by morphologically identifiable synaptic contacts with the gustatory nerve fibers and expression of the synaptic membrane protein-25 (SNAP-25) and NCAM." [GOC:tfm, ISBN:0517223651, PMID:15738192] subset: human_subset subset: mouse_subset synonym: "taste bud basal cell" BROAD [] synonym: "type 3 taste cell" EXACT [] xref: FMA:67940 is_a: CL:0000048 ! multi fate stem cell is_a: CL:0000209 ! taste receptor cell property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-09-13T10:57:21Z [Term] id: CL:0002286 name: type II taste cell def: "A taste receptor cell that has a short microvilli, a projecting apical region, a large rounded nucleus, and expresses taste chemoreceptors thus making them the transducing cell for taste qualities." [GOC:tfm, PMID:15738192] subset: human_subset subset: mouse_subset synonym: "type 2 taste cell" EXACT [] xref: FMA:62381 is_a: CL:0000209 ! taste receptor cell property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-09-13T10:57:26Z [Term] id: CL:0002287 name: type IV taste receptor cell def: "A rounded, mitotically active stem cell which is the source of new cells of the taste bud; located basally." [GOC:tfm, ISBN:0517223651, PMID:15738192] comment: There is debate about the exact lineage of these cell types from this progenitor. See PMID:15738192. subset: human_subset subset: mouse_subset synonym: "taste bud basal cell" BROAD [] synonym: "type 4 taste cell" EXACT [] xref: FMA:62380 is_a: CL:0000034 ! stem cell is_a: CL:0000209 ! taste receptor cell property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-09-13T10:57:29Z [Term] id: CL:0002288 name: type V taste receptor cell def: "A cell type that forms the boundary with the surrounding epithelium." [GOC:tfm, ISBN:0517223651] subset: human_subset subset: mouse_subset xref: FMA:67941 is_a: CL:0000209 ! taste receptor cell property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-09-13T10:57:31Z [Term] id: CL:0002289 name: type I taste bud cell def: "A densely staining taste receptor cell that contains many dense vacuoles in their apical regions which project into the apical space and bear microvilli. This cell type serves as a supporting cell by surrounding and isolating the other cell types from each other; secrete a dense amorphous material that surrounds the microvilli in the taste pore. This cell type expresses a glial glutumate transporter, GLAST." [GOC:tfm, ISBN:0412046911, ISBN:0517223651, PMID:15738192] subset: human_subset subset: mouse_subset synonym: "dark tongue cell" EXACT [] synonym: "type I taste cell" EXACT [] synonym: "type taste 1 cell" EXACT [] xref: FMA:62356 is_a: CL:0000209 ! taste receptor cell is_a: CL:0000703 ! sustentacular cell property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-09-13T10:57:35Z [Term] id: CL:0002290 name: Y chromosome-bearing sperm cell def: "A sperm bearing a Y chromosome. Chromosomal and genetic sex is established at fertilization in mammals and depends upon whether an X-bearing sperm or a Y-bearing sperm fertilizes the X-bearing ovum." [GOC:tfm, ISBN:0721669743] subset: human_subset subset: mouse_subset synonym: "Y bearing sperm" EXACT [] synonym: "Y-bearing sperm" EXACT [] xref: FMA:84058 is_a: CL:0000019 ! sperm property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-09-13T11:35:24Z [Term] id: CL:0002291 name: X chromosome-bearing sperm cell def: "A sperm bearing an X chromosome. Chromosomal and genetic sex is established at fertilization in mammals and depends upon whether an X-bearing sperm or a Y-bearing sperm fertilizes the X-bearing ovum." [GOC:tfm, ISBN:0721669743] subset: human_subset subset: mouse_subset synonym: "X bearing sperm" EXACT [] synonym: "X-bearing sperm" EXACT [] xref: FMA:84057 is_a: CL:0000019 ! sperm property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-09-13T11:35:26Z [Term] id: CL:0002292 name: type I cell of carotid body def: "A round or oval neuroepithelial cell that contacts other type I cells or capillaries. They occur in clusters that are surrounded by sheath cells (type-II cells) in the carotid body. This cell type is capable of secreting a number of neurotransmitters." [GOC:tfm, ISBN:0517223651] subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "glomus cell" EXACT [] xref: FMA:84186 is_a: CL:0000710 ! neurecto-epithelial cell property_value: RO:0002175 NCBITaxon:9606 property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-09-13T01:40:21Z [Term] id: CL:0002293 name: epithelial cell of thymus alt_id: CL:1000459 def: "An epithelial cell of the thymus. Epithelial reticular cells are pleomorphic, stellate, non-phagocytic cells which seem to be supportive in function and are held together by desmosomes. They replace the fibroblastoid reticular cells found in other lymphoid organs. Other epithelial cells in the medulla have the ultrastructure of secretory cells. Although different epithelial cells throughout the thymus appear alike by light microscopy their ultrastructure and function varies." [FMA:72208, GOC:tfm] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "epithelial cell of thymus gland" EXACT [] synonym: "epithelial reticular cell" EXACT [] synonym: "epithelial reticular cell of thymus" EXACT [] synonym: "thymic epithelial cell" EXACT [] xref: CALOHA:TS-1040 xref: FMA:72208 is_a: CL:0002076 {is_inferred="true"} ! endo-epithelial cell intersection_of: CL:0002076 ! endo-epithelial cell intersection_of: BFO:0000050 UBERON:0002370 ! part of thymus relationship: BFO:0000050 UBERON:0002370 ! part of thymus property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-09-13T02:34:22Z [Term] id: CL:0002294 name: type-1 epithelial cell of thymus def: "An epithelial cell with a well defined Golgi apparatus that makes up the continuous layer of cells bordering the thymic tissue beneath the capsule." [GOC:tfm, PMID:9264335] subset: human_subset subset: mouse_subset synonym: "subcapsular thymic epithelial cell" RELATED [PMID:18194204, PMID:2694455] xref: FMA:72209 is_a: CL:0002364 ! cortical thymic epithelial cell property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-09-13T02:37:23Z [Term] id: CL:0002295 name: type-6 epithelial cell of thymus def: "A thymic epithelial cell that has an eccentric, round, or irregularly shaped hetero or euchromatic nucleus. The hallmark of this cell type is the presence of vacuoles, which are clustered in one area of the cytoplasm in the vicinity of the nucleus. The vacuoles are small and acquire a grape-like form, occasionally showing delicate internal microvillous projections." [GOC:tfm, PMID:19721455, PMID:9264335] subset: human_subset subset: mouse_subset synonym: "cystic thymic epithelial cells" EXACT [] synonym: "large medullary thymic epithelial cells" EXACT [] synonym: "large mTEC" EXACT [] xref: FMA:72214 is_a: CL:0002365 ! medullary thymic epithelial cell property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-09-13T02:37:26Z [Term] id: CL:0002296 name: type-4 epithelial cell of thymus def: "An epithelial cell with high nuclear and cytoplasmic electron-density. This cell type is found in the deeper portions of the cortex but is more abundant in the medulla of the thymus." [FMA:0412046911, GOC:tfm, PMID:9264335] subset: human_subset subset: mouse_subset synonym: "dark thymic epithelial cell" EXACT [] xref: FMA:72212 is_a: CL:0002364 ! cortical thymic epithelial cell is_a: CL:0002365 ! medullary thymic epithelial cell property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-09-13T02:37:45Z [Term] id: CL:0002297 name: type-3 epithelial cell of thymus def: "A thymic epithelial cell with moderate nuclear and cytoplasmic electron-density. Scattered in the cortex, this cell type is predominant in the mid and deep cortex." [PMID:9264335] subset: human_subset subset: mouse_subset synonym: "intermediate thymic epithelial cell" EXACT [] xref: FMA:72211 is_a: CL:0002364 ! cortical thymic epithelial cell property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-09-13T02:37:51Z [Term] id: CL:0002298 name: type-5 epithelial cell of thymus def: "A thymic epithelial cell type with low nuclear and cytoplasmic electrondensity; has a round, euchromatic nucleus and occurs in small groups at the corticomedullary junction or scattered singly in the medulla." [GOC:tfm, ISBN:0412046911, PMID:19721455, PMID:9264335] subset: human_subset subset: mouse_subset synonym: "undifferentiated medullary thymic epithelial cell" EXACT [] synonym: "undifferentiated mTEC" EXACT [] synonym: "undifferentiated thymic epithelial cell" EXACT [] xref: FMA:72213 is_a: CL:0002365 ! medullary thymic epithelial cell property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-09-13T02:37:54Z [Term] id: CL:0002299 name: type-2 epithelial cell of thymus def: "An epithelial cell scattered in the cortex, predominant in the outer cortex with a large pale nucleus and a prominent nucleolus." [GOC:tfm, ISBN:0412046911, PMID:9264335] subset: human_subset subset: mouse_subset synonym: "pale thymic epithelial cell" EXACT [] xref: FMA:72210 is_a: CL:0002364 ! cortical thymic epithelial cell property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-09-13T02:37:58Z [Term] id: CL:0002300 name: type-7 epithelial cell of thymus def: "A small medullary thymic epithelial cell with a spindle shape, often arranged in groups and connected to each other by large desmosomes and interdigitations. The cytoplasm is sparse, with scanty organelles and thick bundles of cytokeratin." [GOC:tfm, PMID:19721455] subset: human_subset subset: mouse_subset synonym: "spindle shaped medullary thymic epithelial cell" EXACT [] synonym: "spindle shaped mTEC" EXACT [] is_a: CL:0002365 ! medullary thymic epithelial cell property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-09-13T03:23:25Z [Term] id: CL:0002301 name: type B synovial cell def: "A resident stromal cell located in the synovial membrane and responsible for the production of immune-related cytokines and chemokines. This cell type secretes glycoproteins and hyaluronic acid, has abundant granular endoplasmic reticulum, but contains fewer vacuoles and vesicles." [GOC:tfm, ISBN:0517223651, PMID:34433485, PMID:34772990] comment: Type B synovial cells play a key role in the pathogenesis of chronic inflammatory diseases, such as rheumatoid arthritis, and are essential for the maintenance of normal joint functions. Fibroblast-like synoviocytes from different joints have different properties, which may contribute to the characteristic pattern of joint involvement in different types of arthritis. {xref="https://en.wikipedia.org/wiki/Fibroblast-like_synoviocyte", xref="PMID:34433485"} subset: human_subset subset: mouse_subset synonym: "fibroblast-like synoviocyte" EXACT [] synonym: "synovial fibroblast" EXACT [PMID:23147896] xref: BTO:0003652 xref: FMA:66788 is_a: CL:0000214 ! synovial cell is_a: CL:0000499 ! stromal cell intersection_of: CL:0000499 ! stromal cell intersection_of: BFO:0000050 UBERON:0002018 ! part of synovial membrane of synovial joint relationship: BFO:0000050 UBERON:0002018 ! part of synovial membrane of synovial joint relationship: RO:0002215 GO:0030213 ! capable of hyaluronan biosynthetic process relationship: RO:0003000 UBERON:0001090 ! produces synovial fluid property_value: terms:contributor https://orcid.org/0000-0002-0819-0473 property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-09-13T03:39:14Z [Term] id: CL:0002302 name: type A synovial cell def: "A synovial cell that is macrophage-like, characterized by surface ruffles or lamellipodia, plasma membrane invaginations and associated micropinocytotic vesicles, Golgi apparatus and little granular endoplasmic reticulum." [GOC:tfm, ISBN:0517223651] comment: Type A cells are usually round and located in the upper part of the synovial intima. {xref="PMID:10770586"} subset: human_subset subset: mouse_subset synonym: "type A synoviocyte" EXACT [] xref: FMA:66787 is_a: CL:0000214 ! synovial cell is_a: CL:0000234 ! phagocyte relationship: BFO:0000050 UBERON:0002018 ! part of synovial membrane of synovial joint relationship: RO:0001000 CL:0000842 {xref="PMID:10770586"} ! derives from mononuclear leukocyte property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-09-13T03:39:17Z [Term] id: CL:0002303 name: pigmented ciliary epithelial cell def: "A cell that is part of pigmented ciliary epithelium. This cell type uptakes sodium and chloride ions from stromal interstitium and passes the ions to non-pigmented ciliary epithelial cells via gap junctions." [PMID:15106942] comment: In a consensus model of unidirectional secretion, aqueous humour is formed by transferring solute, principally NaCl, from stroma to posterior chamber, with water passively following the osmotic gradient. Unidirectional secretion comprises three sequential steps. First, NaCl is transferred from the stromal interstitium into the pigmented ciliary epithelial (PE) cells. Second, solute passes from the PE into the non-pigmented ciliary epithelial (NPE) cells through gap junctions. Finally, NPE cells release Na+ and Cl− into the aqueous humour. {xref="https://doi.org/10.1016/j.exer.2003.09.021"} subset: cellxgene_subset subset: eye_upper_slim subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "PE cell" EXACT [https://doi.org/10.1016/j.exer.2003.09.021] xref: FMA:70606 is_a: CL:0000529 ! pigmented epithelial cell relationship: BFO:0000050 UBERON:0001778 ! part of ciliary epithelium property_value: RO:0002175 NCBITaxon:9606 property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0002303" xsd:string {name="pigmented ciliary epithelial cell on CELLxGENE CellGuide"} property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 property_value: terms:description "Pigmented ciliary epithelial cells, which are a type of pigment cell, have a crucial function within the eye's ciliary body. The ciliary body, located behind the iris, is one of the eye’s most vital structures and consists of two types of epithelial cells: the pigmented and the non-pigmented ciliary epithelial cells. The pigmented ciliary epithelial cells form the outer layer of the ciliary body and exhibit a black or brown pigmentation due to the melanin they contain.\nOne key function of pigmented ciliary epithelial cells is to aid in the formation of aqueous humor, an intraocular fluid that nourishes the cornea and lens, and maintains intraocular pressure which is essential for the eye’s shape and light refraction. These cells facilitate this function in conjunction with the non-pigmented ciliary epithelial cells. Together, the pigmented and non-pigmented ciliary epithelial cells form a bilayer epithelium that allows the secretion of aqueous humor through a bi-directional fluid transport mechanism.\nPigmented ciliary epithelial cells also contribute to the blood-aqueous barrier, a physiological frontier that controls the entry and exit of various substances from the blood to the aqueous humor and vice versa. The pigmentation in these cells, intensified by melanin, helps to absorb scattered light coming into the eye, reducing any potential damage and glare.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1016/S1569-2590(05)10005-6", xref="DOI:10.1111/j.1444-0938.2002.tb02384.x"} creation_date: 2010-09-13T04:09:27Z [Term] id: CL:0002304 name: non-pigmented ciliary epithelial cell def: "A cell that is part of non-pigmented ciliary epithelium. This cell type participates in aqueous humor formation by releasing solute, principally sodium and chloride ions received from pigmented epithelial cells via gap junctions, into the aqueous humor of the eye." [GOC:tfm, PMID:15106942] comment: In a consensus model of unidirectional secretion, aqueous humour is formed by transferring solute, principally NaCl, from stroma to posterior chamber, with water passively following the osmotic gradient. Unidirectional secretion comprises three sequential steps. First, NaCl is transferred from the stromal interstitium into the pigmented ciliary epithelial (PE) cells. Second, solute passes from the PE into the non-pigmented ciliary epithelial (NPE) cells through gap junctions. Finally, NPE cells release Na+ and Cl− into the aqueous humour. {xref="https://doi.org/10.1016/j.exer.2003.09.021"} subset: cellxgene_subset subset: eye_upper_slim subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "nonpigmented ciliary epithelial cell" EXACT [PMID:10913011] synonym: "NPE cell" EXACT [https://doi.org/10.1016/j.exer.2003.09.021] xref: FMA:70607 is_a: CL:0000710 ! neurecto-epithelial cell relationship: BFO:0000050 UBERON:0001778 ! part of ciliary epithelium property_value: RO:0002175 NCBITaxon:9606 property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0002304" xsd:string {name="non-pigmented ciliary epithelial cell on CELLxGENE CellGuide"} property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 property_value: terms:description "Non-pigmented ciliary epithelial cells are a specialized cell type found in the ciliary body of the eye. The ciliary body is responsible for producing the aqueous humor, which is the clear, watery fluid that fills the anterior portion of the eye. These cells, also known as the ciliary epithelium's non-pigmented layer, are located immediately beneath the pigmented ciliary epithelial cells. They play several key roles in maintaining eye health and function and contribute to the eye's intricate physiology.\nTogether with the endothelial cells of the iris and ciliary blood vessels, the non-pigmented ciliary epithelium form the blood aqueous barrier in the anterior part of the eye. One of the main functions of non-pigmented ciliary epithelial cells includes the production and regulation of aqueous humor, which provides nourishment and oxygen supply to the avascular lens and cornea, two vital eye components found in the anterior segment. Aqueous humor also helps to maintain intraocular pressure, which is critical for retaining the shape of the eye. Aberrations in this balance often result in ocular pathologies like glaucoma. Non-pigmented ciliary epithelial cells play a key role in the secretory processes that regulate the aqueous humor through active transport, diffusion, and ultrafiltration from the blood plasma. \nTherefore, due to their complex and multi-faceted functions sustaining eye health, non-pigmented ciliary epithelial cells represent a critical cell type in eye biology and physiological equilibrium.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1007/978-1-4615-1203-5_15", xref="DOI:10.1016/S1569-2590(05)10005-6"} creation_date: 2010-09-13T04:09:31Z [Term] id: CL:0002305 name: epithelial cell of distal tubule def: "An epithelial cell of the distal convoluted tubule of the kidney that helps regulate systemic levels of potassium, sodium, calcium, and pH." [GOC:tfm, ISBN:0517223651] subset: cellxgene_subset subset: human_subset subset: kidney_upper_slim subset: mouse_subset synonym: "kidney distal tubule epithelial cell" EXACT [] xref: FMA:70981 xref: KUPO:0001055 is_a: CL:0002078 ! meso-epithelial cell is_a: CL:1000494 {is_inferred="true"} ! nephron tubule epithelial cell is_a: CL:1000615 ! kidney cortex tubule cell intersection_of: CL:0000066 ! epithelial cell intersection_of: BFO:0000050 UBERON:0004135 ! part of distal tubule relationship: BFO:0000050 UBERON:0004135 ! part of distal tubule [Term] id: CL:0002306 name: epithelial cell of proximal tubule def: "An epithelial cell of the proximal tubule of the kidney." [GOC:tfm, ISBN:1-4160-2328-3] comment: The vast majority of proximal tubule epithelial cells have a brush border, but there are rare exceptions. subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: kidney_upper_slim subset: mouse_subset synonym: "kidney proximal tubule epithelial cell" EXACT [] xref: FMA:70973 xref: KUPO:0001044 is_a: CL:0002078 ! meso-epithelial cell is_a: CL:1000494 {is_inferred="true"} ! nephron tubule epithelial cell is_a: CL:1000615 ! kidney cortex tubule cell intersection_of: CL:0000066 ! epithelial cell intersection_of: BFO:0000050 UBERON:0004134 ! part of proximal tubule relationship: BFO:0000050 UBERON:0004134 ! part of proximal tubule property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/2d-ftu/kidney-renal-corpuscle/v1.2/assets/2d-ftu-kidney-renal-corpuscle.png" xsd:string {terms:licence="http://creativecommons.org/licenses/by/4.0/", xref="doi:10.48539/HBM778.SHGJ.294"} property_value: RO:0002175 NCBITaxon:9606 property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0002306" xsd:string {name="epithelial cell of proximal tubule on CELLxGENE CellGuide"} property_value: terms:description "An epithelial cell of the proximal tubule, commonly referred to as a proximal tubular epithelial cell, is a specialized brush border cell found lining the proximal tubule within the functional unit of the kidney, the nephron. These cells play a critical role in the resorption process in the kidney and are responsible for maintaining homeostasis, including blood filtration, electrolyte balance, and acid-base balance. Epithelial cells of the proximal tubule have a cuboidal shape and microvilli that increase surface area, facilitating effective reabsorption.\nThe primary function of epithelial cells of the proximal tubule revolves around their ability to reabsorb approximately 60-70% of the glomerular filtrate, retaining essential substances such as sodium, glucose, amino acids, bicarbonate, and certain ions that are filtered out by the glomerulus. Additionally, these cells are also responsible for the secretion of organic acids, bases, and the hydrolysis of small proteins that are reabsorbed after filtration. \nProximal tubule epithelial cells are highly susceptible to apoptosis, and damage to these cells by exposure to toxins, pathogens, or obstructive conditions may result in acute kidney injury.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1002/cphy.c110061", xref="DOI:10.1007/s11033-020-05977-4", xref="DOI:10.1038/ki.2011.120", xref="DOI:10.1073/pnas.0405179101", xref="DOI:10.2215/CJN.02440314"} [Term] id: CL:0002307 name: brush border cell of the proximal tubule def: "A brush border epithelial cell located in the proximal tubule of the kidney, essential for reabsorbing substances like glucose and amino acids from the glomerular filtrate. These cells also secrete organic ions, playing a crucial role in maintaining kidney homeostasis, including electrolyte and acid-base balance, and excreting metabolic waste." [GOC:tfm, ISBN:1-4160-2328-3, PMID:23799132] comment: The vast majority of proximal tubule epithelial cells have a brush border, but there are rare exceptions. subset: human_subset subset: mouse_subset is_a: CL:0000239 ! brush border epithelial cell is_a: CL:0002306 ! epithelial cell of proximal tubule intersection_of: CL:0002306 ! epithelial cell of proximal tubule intersection_of: BFO:0000051 GO:0005903 ! has part brush border property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-09-14T11:29:20Z [Term] id: CL:0002308 name: epithelial cell of skin gland def: "An epithelial cell of a skin gland." [GOC:tfm] subset: human_subset subset: mouse_subset synonym: "epithelial cell of gland of skin" EXACT [] xref: FMA:70657 is_a: CL:0002159 ! general ecto-epithelial cell intersection_of: CL:0000066 ! epithelial cell intersection_of: BFO:0000050 UBERON:0002419 ! part of skin gland relationship: BFO:0000050 UBERON:0002419 ! part of skin gland property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-09-14T12:00:07Z [Term] id: CL:0002309 name: corticotroph def: "A basophil chromphil cell of the anterior pitiutary gland that produce adrenocorticotropic hormone, melanocyte-stimulating hormone and lipotropin. This cell type is irregular in shape and has short dendritic processes which are inserted among other neighboring cells;" [GOC:tfm, ISBN:0517223651] subset: human_subset subset: mouse_subset xref: BTO:0002509 xref: FMA:83098 xref: MESH:D052680 is_a: CL:0000467 ! adrenocorticotropic hormone secreting cell is_a: CL:0000639 ! basophil cell of pars distalis of adenohypophysis property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-09-14T02:08:23Z [Term] id: CL:0002310 name: mammosomatotroph def: "An acidophil cell of the anterior pituitary gland that produces both prolactin and growth hormone." [GOC:tfm] subset: human_subset subset: mouse_subset xref: FMA:83097 is_a: CL:0000295 ! somatotropin secreting cell is_a: CL:0000439 ! prolactin secreting cell is_a: CL:0000638 ! acidophil cell of pars distalis of adenohypophysis property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-09-14T02:25:34Z [Term] id: CL:0002311 name: mammotroph def: "An acidophilic cell of the anterior pituitary that produces prolactin." [SANBI:mhl] subset: human_subset subset: mouse_subset synonym: "epsilon-acidophil" EXACT [] synonym: "lactotrope" EXACT [] synonym: "lactotroph" EXACT [] synonym: "lactotropic cell" EXACT [] synonym: "mammotrope" EXACT [] synonym: "mammotrophic cell" EXACT [] synonym: "mammotropic cell" EXACT [] xref: FMA:83096 is_a: CL:0000439 ! prolactin secreting cell is_a: CL:0000638 ! acidophil cell of pars distalis of adenohypophysis property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-09-14T02:30:57Z [Term] id: CL:0002312 name: somatotroph def: "An acidophilic cell of the anterior pituitary that produces growth hormone, somatotropin." [SANBI:mhl] subset: human_subset subset: mouse_subset synonym: "somatotrope" EXACT [] synonym: "somatotropic cell" EXACT [] synonym: "somatrophic cell" EXACT [] xref: FMA:83095 xref: MESH:D052683 is_a: CL:0000295 ! somatotropin secreting cell is_a: CL:0000638 ! acidophil cell of pars distalis of adenohypophysis property_value: skos:prefLabel "somatotroph" xsd:string property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-09-14T02:33:09Z [Term] id: CL:0002313 name: endocrine-paracrine cell of prostate gland def: "An ecto-epithelial cell of the prostate gland that secretes hormones." [GOC:tfm] subset: human_subset subset: mouse_subset synonym: "glandular cell of prostate" EXACT [] synonym: "neuro-epithelial cell of prostate gland" EXACT [] xref: CALOHA:TS-1280 xref: FMA:74390 xref: FMA:86774 is_a: CL:0000150 ! glandular secretory epithelial cell is_a: CL:0002159 ! general ecto-epithelial cell intersection_of: CL:0002159 ! general ecto-epithelial cell intersection_of: BFO:0000050 UBERON:0002367 ! part of prostate gland intersection_of: RO:0002215 GO:0046879 ! capable of hormone secretion relationship: BFO:0000050 UBERON:0002367 ! part of prostate gland relationship: RO:0002215 GO:0046879 ! capable of hormone secretion property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-09-14T03:01:58Z [Term] id: CL:0002314 name: external supporting cell of vestibular epithelium def: "An auditory epithelial support cell located in the vestibular epithelium that has many hallmarks of glial cells. This cell type express glial markers such as vimentin, S100, glutamate-aspartate transporter, low affinity neurotrophin receptor p75, glial fibrillary acidic protein, and proteolipid protein." [GOC:tfm, PMID:20837532] subset: human_subset subset: mouse_subset xref: FMA:75809 is_a: CL:0002316 ! supporting cell of vestibular epithelium property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-09-14T03:20:01Z [Term] id: CL:0002315 name: supporting cell of cochlea def: "An epithelial supporting cell located in the cochlea." [GOC:tfm] subset: human_subset subset: mouse_subset xref: FMA:79796 is_a: CL:0001035 ! bone cell is_a: CL:0005014 ! auditory epithelial supporting cell intersection_of: CL:0005014 ! auditory epithelial supporting cell intersection_of: BFO:0000050 UBERON:0001844 ! part of cochlea relationship: BFO:0000050 UBERON:0001844 ! part of cochlea property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-09-14T03:31:38Z [Term] id: CL:0002316 name: supporting cell of vestibular epithelium def: "A supporting cell of the vestibular epithelium." [GOC:tfm, PMID:20837532] subset: cellxgene_subset subset: human_subset subset: mouse_subset xref: FMA:75607 is_a: CL:0005014 ! auditory epithelial supporting cell intersection_of: CL:0005014 ! auditory epithelial supporting cell intersection_of: BFO:0000050 UBERON:0001862 ! part of vestibular labyrinth relationship: BFO:0000050 UBERON:0001862 ! part of vestibular labyrinth property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-09-14T03:31:44Z [Term] id: CL:0002317 name: external limiting cell of vestibular epithelium def: "An external limiting cell found in the vestibular epithelium." [GOC:tfm] subset: human_subset subset: mouse_subset xref: FMA:75808 is_a: CL:0002316 ! supporting cell of vestibular epithelium property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-09-14T03:33:50Z [Term] id: CL:0002318 name: peripheral blood mesothelial cell def: "A mesothelial cell capable of circulating in the blood by first losing its squamous character. This cell can incorporate into the regenerating mesothelium." [GOC:tfm, PMID:14592528] subset: human_subset subset: mouse_subset xref: FMA:86712 is_a: BFO:0000002 is_a: CL:0000081 ! blood cell is_a: CL:0000255 ! eukaryotic cell relationship: RO:0002202 CL:0000077 ! develops from mesothelial cell property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-09-15T10:47:11Z [Term] id: CL:0002319 name: neural cell def: "A cell that is part of the nervous system." [GOC:tfm, ISBN:0618947256] subset: cellxgene_subset subset: general_cell_types_upper_slim subset: human_subset subset: mouse_subset xref: CALOHA:TS-2040 xref: FMA:70333 is_a: CL:0000255 ! eukaryotic cell intersection_of: CL:0000000 ! cell intersection_of: BFO:0000050 UBERON:0001016 ! part of nervous system relationship: BFO:0000050 UBERON:0001016 ! part of nervous system property_value: skos:prefLabel "neural cell" xsd:string property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-09-15T01:34:57Z [Term] id: CL:0002320 name: connective tissue cell alt_id: CL:1000406 def: "A cell of the supporting or framework tissue of the body, which includes adipose tissue, cartilage, and bone. In vertebrates, this cell arises chiefly from the embryonic mesoderm and, in cranial regions, from neural crest." [GOC:tfm, ISBN:0618947256, PMID:19198652, PMID:26043871, PMID:31194383] subset: cellxgene_subset subset: general_cell_types_upper_slim subset: human_subset subset: mouse_subset xref: CALOHA:TS-2096 xref: FMA:63875 xref: MESH:D003239 xref: ZFA:0009392 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000255 ! eukaryotic cell intersection_of: CL:0000000 ! cell intersection_of: BFO:0000050 UBERON:0002384 ! part of connective tissue relationship: BFO:0000050 UBERON:0002384 ! part of connective tissue property_value: skos:prefLabel "connective tissue cell" xsd:string property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-09-15T03:01:54Z [Term] id: CL:0002321 name: embryonic cell (metazoa) def: "A cell of the embryo." [FMA:0618947256] subset: human_subset subset: mouse_subset xref: CALOHA:TS-0263 xref: FMA:82840 xref: WBbt:0007028 xref: ZFA:0007089 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000000 ! cell property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0002321" xsd:string {name="embryonic cell (metazoa) on CELLxGENE CellGuide"} property_value: skos:prefLabel "embryonic cell (metazoa)" xsd:string property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 property_value: terms:description "Embryonic cells in metazoans, which include all multicellular animals, are biological units in their earliest developmental stages from conception until the organism is fully formed. \nThey are derived from a fertilized egg, which undergoes a series of cell divisions to produce a multicellular organism. During the early phases of embryonic development, these cells exhibit pluripotency, meaning they possess the potential to differentiate into a diverse array of specialized cell types that constitute different body tissues and structures. \nThe balance between cell proliferation and differentiation in embryonic cells is crucial for successful development. When cells continue to divide without differentiating, overgrowth may occur leading to conditions such as teratomas (tumors of embryonic cells). Conversely, if cell differentiation proceeds at the expense of cell proliferation, developmental anomalies could occur regarding size or mass of the organism or its parts.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1002/iub.1404", xref="DOI:10.1093/molehr/gan048", xref="https://www.ncbi.nlm.nih.gov/books/NBK9906/"} creation_date: 2010-09-15T03:39:21Z [Term] id: CL:0002322 name: embryonic stem cell def: "A stem cell of embryonic origin." [GOC:dsd, GOC:tfm, ISBN:068340007X, PMID:18179856] comment: This is an in vitro cell type and may be removed in future releases. These cells are reportedly SSEA-4-positive, CD73-negative, and CD324-positive. subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "ESC" EXACT [] xref: BTO:0001086 xref: CALOHA:TS-0263 xref: FMA:82841 xref: MESH:D053595 is_a: CL:0000034 ! stem cell is_a: CL:0002321 ! embryonic cell (metazoa) property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-09-15T03:44:35Z [Term] id: CL:0002323 name: amniocyte def: "A cell of a fetus which is suspended in the amniotic fluid. Amniocytes are considered to arise from several tissues including fetal skin, the fetal urinary tract, umbilical cord, and the inner amniotic surface." [BFO:0000066, GOC:tfm, PMID:3211847] subset: human_subset subset: mouse_subset xref: BTO:0000066 is_a: CL:0000349 {is_inferred="true"} ! extraembryonic cell intersection_of: CL:0000349 ! extraembryonic cell intersection_of: RO:0001025 UBERON:0000173 ! located in amniotic fluid relationship: RO:0001025 UBERON:0000173 ! located in amniotic fluid property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-09-20T10:13:37Z [Term] id: CL:0002324 name: basal-myoepithelial cell of mammary gland def: "A myoepithelial cell that is part of a mammary gland and is located in the basal layer. During lactation, a basal-myoepithelial cell of mammary gland contracts under the stimulation of oxytocin. In humans, a basal-myoepithelial cell of mammary gland can be identified by high levels of CD49f and low levels of EpCAM." [GOC:tfm, PMID:11250738, PMID:19022771, PMID:38059556] comment: Due inconsistencies in naming this and other mammary gland epithelial cell types, several mammary gland experts gathered for a breast atlas annotation jamboree organized by Chan-Zuckerberg initiative. They agreed to label this cell type as basal-myoepithelial cell (and abbreviated: B-Myo cell). {xref="PMID:38059556"} subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "B-Myo cell" RELATED OMO:0003000 [] synonym: "basal" RELATED OMO:0003000 [PMID:37380767] synonym: "basal cell of lactiferous duct" NARROW [FMA:67800] synonym: "basal myoepithelial cell" BROAD [PMID:37694522] synonym: "basal-myoepithelial cell" BROAD [PMID:37380767] synonym: "BM" RELATED OMO:0003000 [PMID:38059556] synonym: "myoepithelial cell of lactiferous gland" NARROW [] synonym: "myoepithelial cell of mammary gland" EXACT [PMID:11250738] xref: CALOHA:TS-2378 xref: FMA:67800 is_a: CL:0000185 ! myoepithelial cell is_a: CL:0002327 ! mammary gland epithelial cell intersection_of: CL:0000185 ! myoepithelial cell intersection_of: BFO:0000050 UBERON:0001911 ! part of mammary gland property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0002324" xsd:string {name="basal-myoepithelial cell of mammary gland on CELLxGENE CellGuide"} property_value: terms:contributor https://orcid.org/0000-0001-6677-8489 property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 property_value: terms:contributor https://orcid.org/0000-0003-4969-670X property_value: terms:description "Myoepithelial cells of the mammary gland are a specialized type of smooth muscle cell that plays a vital role in lactation and the normal functioning of the mammary gland. Their unique elongated, stellate shape allows them to wrap around the ductal and alveolar units of the gland. \nMyoepithelial cells of the mammary gland facilitate the expulsion of milk during lactation in response to signaling by the hormone oxytocin. Due to their cytoskeletal composition of actin and myosin, which mirrors that of smooth muscle cells, these cells are able to contract and advance the milk from the alveoli into the ducts, and eventually to the nipple, enabling breastfeeding. \nOther critical roles of myoepithelial cells of the mammary gland include the maintenance of mammary gland integrity and the suppression of tumor formation. They create a mechanical barrier that separates the luminal epithelial cells from the stromal compartment and play a significant role in the suppression of carcinogenesis; loss or alteration of these cells often paves the way for invasive carcinomas. Moreover, these cell types produce extracellular matrix proteins such as fibronectin that help in the synthesis of the basement membrane, providing structural support to the gland and maintaining its overall health and integrity.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1007/s10911-005-9586-4", xref="DOI:10.1186/bcr1286", xref="DOI:10.1186/bcr459"} creation_date: 2010-09-20T11:42:14Z [Term] id: CL:0002325 name: lactocyte alt_id: CL:0002230 alt_id: CL:1000476 def: "A milk-producing glandular epithelial cell that is part of a mammary gland alveolus and differentiates from a luminal adaptive secretory precursor cell during secretory differentiation (also termed lactogenesis I). Following secretory activation (also termed lactogenesis II), a lactocyte is involved in the synthesis and/or transport of milk constituents including proteins, oligosaccharides, lactose, micronutrients, fat, hormones, immunoglobulins, and cytokines into the lumen of the lactating mammary gland." [doi:10.1177/156482659601700404, GOC:tfm, PMID:19022771, PMID:28717367, PMID:35091553, PMID:35377806] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "epithelial cell of lactiferous gland" EXACT [] synonym: "lactaction-associated mammary epithelial cell" EXACT [PMID:35091553] synonym: "lactation-derived mammary cell" EXACT [PMID:35091553] synonym: "LMC" RELATED OMO:0003000 [PMID:35091553] synonym: "luminal cell of alveolus of lactiferous gland" EXACT [] synonym: "mammary alveolar cell" BROAD [PMID:19022771] synonym: "mammary alveolar epithelial cell" EXACT [] synonym: "mammary gland alveolar epithelial cell" EXACT [] xref: FMA:74506 xref: FMA:79866 is_a: CL:0000314 ! milk secreting cell is_a: CL:0002159 {is_inferred="true"} ! general ecto-epithelial cell is_a: CL:1001586 ! mammary gland glandular cell intersection_of: CL:0000150 ! glandular secretory epithelial cell intersection_of: BFO:0000050 UBERON:0003214 ! part of mammary gland alveolus relationship: BFO:0000050 UBERON:0003214 ! part of mammary gland alveolus relationship: RO:0002202 CL:4033057 ! develops from luminal adaptive secretory precursor cell of mammary gland property_value: terms:contributor https://orcid.org/0000-0001-6677-8489 property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 property_value: terms:contributor https://orcid.org/0000-0003-4361-817X creation_date: 2010-09-20T01:30:57Z [Term] id: CL:0002326 name: luminal epithelial cell of mammary gland def: "A mammary epithelial cell that occurs in the lumen of the ductal and alveoli structure in the breast." [GOC:tfm, PMID:19022771] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "mature luminal cell" BROAD [PMID:21930782] xref: FMA:73280 is_a: BFO:0000002 is_a: CL:0000069 ! branched duct epithelial cell is_a: CL:0002327 ! mammary gland epithelial cell relationship: RO:0002202 CL:0009116 ! develops from progenitor cell of mammary luminal epithelium property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0002326" xsd:string {name="luminal epithelial cell of mammary gland on CELLxGENE CellGuide"} property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 property_value: terms:description "The luminal epithelial cells of the mammary gland are a key constituent of the glandular tissue in the mammalian breast. Packed into complex structures known as mammary ducts and lobules, these specialized cell types derive their nomenclature from their location within these units - specifically against the inner surface or 'lumen'. \nThe main physiological functions they perform are the synthesis, storage, and secretion of milk. During lactation, these cells synthesize the various macromolecular constituents of milk, such as lipids, proteins, and lactose, which are then secreted into the ductal lumen. An intricately coordinated mix of hormonal activation and signaling pathways, involving prolactin and oxytocin amongst others, regulate this process. Luminal cells also exhibit receptivity towards estrogen, and their proliferation is influenced by estrogen and progesterone.\nLuminal epithelial cells are also engaged in several other key aspects of mammary gland biology. They carry a role in the formation of the ductal tree during the developmental process and are involved in glandular remodeling during pregnancy and post-weaning involution. Furthermore, luminal epithelial cells, just like other cell types in the breast, are susceptible to oncogenic transformation. In fact, the majority of breast cancers, specifically those classified as ductal carcinomas, are believed to originate from this cell population, underlining the pathophysiological significance of these cells.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1038/s41467-021-27895-0", xref="DOI:10.1101/gad.242511.114", xref="DOI:10.1152/physrev.00040.2018", xref="DOI:10.1186/bcr1411"} creation_date: 2010-09-20T01:37:53Z [Term] id: CL:0002327 name: mammary gland epithelial cell def: "An epithelial cell of the mammary gland." [GOC:tfm, PMID:19022771] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "breast epithelial cell" EXACT [] synonym: "mammary epithelial cell" EXACT [] xref: BTO:0004300 is_a: CL:0000066 ! epithelial cell intersection_of: CL:0000066 ! epithelial cell intersection_of: BFO:0000050 UBERON:0001911 ! part of mammary gland relationship: BFO:0000050 UBERON:0001911 ! part of mammary gland property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0002327" xsd:string {name="mammary gland epithelial cell on CELLxGENE CellGuide"} property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 property_value: terms:description "Mammary gland epithelial cells, also known as mammary epithelial cells, are essential cell types in the tissue of mammary glands, which are milk-producing glands in female mammals. They can be categorized into two types: luminal epithelial cells and myoepithelial cells, each with their distinct functions in milk processing and delivery.\nLuminal epithelial cells, which are located in the inner layer of the mammary gland ducts and alveoli, play a vital role in the secretion of milk proteins and lipids to form milk during lactation. These cells contain well-developed secretory apparatus, including rough endoplasmic reticulum and Golgi complex, facilitating the synthesis and secretion of milk proteins. Luminal epithelial cells express markers, like cytokeratin 8 and 18, and hormone receptors, such as estrogen and progesterone receptors, which play a crucial role in regulating the cell proliferation during the mammary gland development and lactation.\nMyoepithelial cells, on the other hand, are contractile cells situated between the luminal epithelial cells and the basal lamina in the ducts and alveoli of the mammary gland. They express markers such as smooth muscle actin and p63. One of their chief functions is the contraction during lactation, which aids in the expulsion of milk from the alveoli into the ductal network. Additionally, myoepithelial cells play a role in shaping the mammary gland ductal system and initiating the involution process after weaning.\nThe homeostasis and functionality of the mammary epithelial cells are sensitive to hormonal regulation and surrounding microenvironment cues. Any abnormalities in these two types of mammary epithelial cells could disrupt the mammary gland function and potentially prompt the development of breast diseases, including cancer.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1016/j.isci.2021.102413", xref="DOI:10.1038/s41574-022-00742-y", xref="DOI:10.1083/jcb.200107065", xref="DOI:10.1101/gad.242511.114", xref="DOI:10.3390/ijms23073883"} creation_date: 2010-09-20T01:49:37Z [Term] id: CL:0002328 name: bronchial epithelial cell def: "An epithelial cell of the bronchus." [GOC:tfm] subset: cellxgene_subset subset: human_subset subset: mouse_subset xref: BTO:0002922 is_a: CL:0002202 ! epithelial cell of tracheobronchial tree intersection_of: CL:0000066 ! epithelial cell intersection_of: BFO:0000050 UBERON:0002185 ! part of bronchus relationship: BFO:0000050 UBERON:0002031 ! part of epithelium of bronchus property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-09-20T02:00:00Z [Term] id: CL:0002329 name: basal epithelial cell of tracheobronchial tree def: "An epithelial cell type that lacks the columnar shape typical for other respiratory epithelial cells. This cell type is able to differentiate into other respiratory epithelial cells in response to injury." [GOC:tfm] subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset is_a: CL:0002202 ! epithelial cell of tracheobronchial tree property_value: RO:0002175 NCBITaxon:9606 property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0002329" xsd:string {name="basal epithelial cell of tracheobronchial tree on CELLxGENE CellGuide"} property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 property_value: terms:description "The basal epithelial cells of the tracheobronchial tree are critical components found in the lining of the airway passages, including the trachea and bronchi. They are keratin-5-positive, nonciliated, cuboidal cells and typically tightly attached to the basement membrane. In humans, the proportion of basal cells in the respiratory epithelium gradually decreases going down the tracheobronchial tree: they represent approximately 34% of the cells in the trachea, 27% in the large airways, and 10% in the small airways, although it is worth noting that there are differences in the compositions of the tracheobronchial epithelia between different species.\nBasal epithelial cells serve as the basal layer of the tracheobronchial epithelium, providing both structural and regenerative support for the epithelial tissue that lines the upper regions of the respiratory tract. They serve as progenitor or stem cells that are capable of differentiating into multiple cell types, such as ciliated and secretory cells. This gives them a central role in homeostatic maintenance of the epithelium, and in repairing damaged epithelium after an injury or during disease. This regenerative capacity is crucial in maintaining the integrity of the tracheobronchial surface, especially given its continual exposure to inhaled irritants and microorganisms. \nIn addition to their primary restorative function, basal epithelial cells are also involved in the initial immune response within the tracheobronchial tree. Equipped with pattern recognition receptors, these cells can identify and respond to pathogenic organisms, triggering an immune response and producing a range of inflammatory mediators, such as cytokines and chemokines, to help combat infections.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1165/rcmb.2013-0049OC", xref="DOI:10.1186/s12931-014-0160-8", xref="DOI:10.2353/ajpath.2010.090870"} creation_date: 2010-09-20T02:10:36Z [Term] id: CL:0002330 name: undifferentiated cell of bronchus epithelium def: "An undifferentiated columnar cell of the bronchus epithelium" [GOC:tfm, PMID:18757316] subset: human_subset subset: mouse_subset is_a: CL:0002328 ! bronchial epithelial cell property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-09-20T02:17:58Z [Term] id: CL:0002332 name: multiciliated epithelial cell of the bronchus def: "A multi-ciliated epithelial cell located in the bronchus epithelium, characterized by a columnar shape and motile cilia on its apical surface." [GOC:tfm, PMID:18757316] subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "ciliated epithelial cell of the bronchus" EXACT [] is_a: CL:0002145 ! multiciliated columnar cell of tracheobronchial tree is_a: CL:0002328 ! bronchial epithelial cell intersection_of: CL:0000075 ! columnar/cuboidal epithelial cell intersection_of: BFO:0000050 UBERON:0002031 ! part of epithelium of bronchus intersection_of: BFO:0000051 GO:0031514 ! has part motile cilium intersection_of: RO:0000053 PATO:0010007 ! has characteristic multiciliated property_value: RO:0002175 NCBITaxon:9606 property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0002332" xsd:string {name="multiciliated epithelial cell of the bronchus on CELLxGENE CellGuide"} property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 property_value: terms:description "The ciliated cell of the bronchus is a specialized type of epitheliali cell found in the lining of the bronchus, which is part of the tracheobronchial tree. These cells are characterized by the presence of hair-like structures called cilia on their surface. The primary function of these cilia is the active transport of mucus and trapped particles out of the respiratory tract.\nCiliated cells of the bronchus form a crucial part of the body's innate defensive mechanism: They function as a barrier and play a key role in the mucociliary clearance mechanism - the coordinated, wave-like movement of the cilia that sweeps pathogens and particles trapped within the mucus in the airways, upward and out of the lungs, either to be swallowed or expelled by coughing. By doing so, these cells are crucial for preventing the lodging of pathogens deep in the lungs and hence reduce the risk of respiratory infections.\nIn conditions affecting the respiratory tract, including chronic obstructive pulmonary disease (COPD) and asthma, the normal functioning of the ciliated cells may be compromised. For instance, the cilia may become impaired or destroyed due to exposure to harmful substances such as cigarette smoke, which can hinder the process of mucus removal, leading to a build-up of mucus and increased susceptibility to infection.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1101/cshperspect.a028241", xref="DOI:10.1111/resp.12542", xref="DOI:10.1146/annurev-physiol-021014-071931"} creation_date: 2010-09-20T02:21:12Z [Term] id: CL:0002333 name: neural crest derived adipocyte def: "An adipocyte derived from a neural crest cell." [GOC:tfm, PMID:17507398] subset: human_subset subset: mouse_subset is_a: CL:0000136 ! adipocyte intersection_of: CL:0000136 ! adipocyte intersection_of: RO:0002202 CL:0000333 ! develops from migratory neural crest cell relationship: RO:0002202 CL:0000005 ! develops from neural crest derived fibroblast property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-09-20T02:25:25Z [Term] id: CL:0002334 name: preadipocyte def: "An undifferentiated fibroblast that can be stimulated to form a fat cell." [GOC:tfm, PMID:18793119] subset: cellxgene_subset subset: human_subset subset: mouse_subset xref: BTO:0001107 is_a: CL:0000057 ! fibroblast property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0002334" xsd:string {name="preadipocyte on CELLxGENE CellGuide"} property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 property_value: terms:description "A preadipocyte is an immature precursor to adipocytes, which are specialized cells primarily tasked with the storage of energy in the form of lipids, making them key in metabolic regulation and overall energy homeostasis. Preadipocytes are present in the stromal vascular fraction of adipose tissues and can be identified by their fibroblastic morphology and the expression of specific markers such as Pref-1, CD24, CD34, and CD29.\nThe primary function of preadipocytes is to proliferate and differentiate into mature adipocytes upon receiving the appropriate physiological and hormonal stimuli. The process of adipogenesis, involving the differentiation of preadipocytes, is controlled by a complex network of transcription factors, including the peroxisome proliferator-activated receptor gamma (PPARγ) and members of the CCAAT/enhancer-binding proteins (C/EBPs) family. Through adipogenesis, preadipocytes contribute to the body's energy storage and insulation capabilities and act as a buffer to control the levels of free fatty acids in the bloodstream. When the energy balance of the body alters, for example during fasting or overnutrition, preadipocytes can respond by modulating adipogenic differentiation and lipid storage, illustrating their dynamic role in metabolic regulation.\nAdditionally, research has shown that preadipocytes also contribute to endocrine function. They produce and secrete several adipokines such as leptin, adiponectin, and resistin. These adipokines impact a variety of physiological processes, including appetite regulation, insulin sensitivity, inflammation, and immune responses. Dysregulation of preadipocyte function and adipogenesis is associated with obesity and related metabolic disorders, such as type 2 diabetes and cardiovascular disease.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1007/s12015-017-9774-9", xref="DOI:10.1128/MCB.01344-13", xref="DOI:10.1186/s12950-018-0185-8", xref="DOI:10.3389/fendo.2023.1199589"} creation_date: 2010-09-20T02:31:53Z [Term] id: CL:0002335 name: brown preadipocyte def: "A preadipocyte that is capable of differentiating into a brown adipocyte. This cell type expresses uncoupling protein-1, PPAR-gamma, PR-domain-containing 16; and PGC-1alpha (peroxisome proliferator-activated receptor-gamma (PPARgamma) coactivator-1alpha)." [GOC:tfm, PMID:18719589] subset: cellxgene_subset subset: human_subset subset: mouse_subset is_a: CL:0002334 ! preadipocyte property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0002335" xsd:string {name="brown preadipocyte on CELLxGENE CellGuide"} property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 property_value: terms:description "Brown preadipocytes are a type of precursor cell vital in the development and function of brown adipose tissue (BAT). These immature cells are capable of proliferating and differentiating into mature brown adipocytes. Brown preadipocytes are distinct in their thermogenic potential due to their capacity to become brown adipocytes, known for heat generation, which is especially crucial in maintaining body temperature in cold environments. These cells are primarily found in mammalian organisms, particularly those that need to adapt to lower temperatures. \nFunctionally, brown preadipocytes play an instrumental role in the process of adipogenesis, which is the formation of adipose (fat-storing) tissue. When subjected to specific stimuli or under the appropriate conditions, these cells can differentiate into mature brown adipocytes. These adipocytes contain a high volume of mitochondria and have the unique ability to burn energy and release it as heat, a process known as thermogenesis. This unique energy expenditure process is chiefly due to the presence of a mitochondrial protein called uncoupling protein 1 (UCP1).\nThe study of brown preadipocytes and their subsequent conversion into mature brown adipocytes is of significant interest in tackling obesity and related metabolic disorders. Since their thermogenic activity contributes to energy expenditure, they provide an attractive target for approaches looking to increase energy consumption in the body. Emerging research suggests that enhancing the number or activity of brown adipocytes could be a possible avenue for therapeutic interventions against obesity and type 2 diabetes.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1038/nrendo.2016.136", xref="DOI:10.1152/physrev.00015.2003", xref="DOI:10.3109/07853890.2010.535557", xref="DOI:10.3389/fphys.2015.00004"} creation_date: 2010-09-20T02:38:38Z [Term] id: CL:0002336 name: buccal mucosa cell def: "An endothelial cell that lines the oral cavitiy including the mucosa of the gums, the palate, the lip, and the cheek." [GOC:tfm, MESH:D009061] subset: human_subset subset: mouse_subset is_a: CL:0002261 ! endothelial cell of viscerocranial mucosa property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-09-20T02:52:54Z [Term] id: CL:0002337 name: keratinocyte stem cell def: "A stem cell found in the basal layer of the epidermis, hair follicle, and sebaceous gland, characterised by its quiescent nature, high proliferative potential, and capacity for long-term self-renewal. This cell maintains epidermal homeostasis by producing transit-amplifying cells that differentiate to replenish the stratified squamous epithelium." [PMID:15339667, PMID:20568222, PMID:9520465] subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "KSC" RELATED OMO:0003000 [PMID:9520465] is_a: CL:0000048 ! multi fate stem cell is_a: CL:0000312 ! keratinocyte is_a: CL:0011026 ! progenitor cell relationship: RO:0002215 GO:0036334 ! capable of epidermal stem cell homeostasis property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/2d-ftu/skin-hair-follicle/v1.0/assets/2d-ftu-skin-hair-follicle.png" xsd:string {terms:licence="http://creativecommons.org/licenses/by/4.0/", xref="doi:10.48539/HBM853.HLFH.534"} property_value: RO:0002175 NCBITaxon:9606 property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0002337" xsd:string {name="keratinocyte stem cell on CELLxGENE CellGuide"} property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 property_value: terms:description "Keratinocyte stem cells are a subpopulation of cells located in the basal layer, or stratum basale, of the epidermis, in the bulge region of hair follicles, and in sebaceous glands. The primary function of keratinocyte stem cells is to renew the skin tissue, the primary barrier that protects our bodies from external environmental factors. To perform this function, keratinocyte stem cells possess the ability to self-renew, maintaining their population, and to produce transient amplifying (TA) cells, which replicate rapidly and differentiate into keratinocytes.\nThe differentiation of keratinocyte stem cells into mature keratinocytes is crucial for skin integrity and health. Specifically, mature keratinocytes give rise to the stratum corneum, the outermost barrier layer of the skin. Throughout this process, keratinocytes produce several types of keratin—structural proteins that contribute to the mechanical resistance and elasticity of the skin. Anomalies in this procedure might lead to a variety of skin disorders, such as psoriasis and skin cancer, highlighting the critical role of keratinocyte stem cells in skin homeostasis.\nIn addition to their role in skin homeostasis and wound healing, recent research suggests that keratinocyte stem cells have potential in regenerative medicine, specifically in the treatment of skin injuries and diseases.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1002/jcp.22275", xref="DOI:10.1038/s41467-019-12559-x", xref="DOI:10.3389/fimmu.2022.786859"} creation_date: 2010-09-20T03:07:03Z [Term] id: CL:0002338 name: CD56-positive, CD161-positive immature natural killer cell, human def: "A natural killer cell that is developmentally immature, has the phenotype CD34-negative, CD56-positive, CD117-positive, CD122-positive,and CD161-positive." [GO_REF:0000031, GOC:add, ISBN:0781735149, PMID:12457618] comment: Human markers; killer cell immunoglobulin-like receptor 2DL1 is used as a representative example (PRO at this time lacks a KIR superfamily). subset: cellxgene_subset subset: human_subset synonym: "p-NK" RELATED [PMID:12457618] is_a: CL:0000823 ! immature natural killer cell intersection_of: CL:0000823 ! immature natural killer cell intersection_of: CL:4030046 PR:000001003 ! lacks_plasma_membrane_part CD34 molecule intersection_of: RO:0002104 PR:000001024 ! has plasma membrane part neural cell adhesion molecule 1 intersection_of: RO:0002104 PR:000001381 ! has plasma membrane part interleukin-2 receptor subunit beta intersection_of: RO:0002104 PR:000001874 ! has plasma membrane part KLRB1-like protein intersection_of: RO:0002104 PR:000002065 ! has plasma membrane part mast/stem cell growth factor receptor intersection_of: RO:0002162 NCBITaxon:9606 ! in taxon Homo sapiens relationship: CL:4030046 PR:000001003 ! lacks_plasma_membrane_part CD34 molecule relationship: RO:0002104 PR:000001024 ! has plasma membrane part neural cell adhesion molecule 1 relationship: RO:0002104 PR:000001381 ! has plasma membrane part interleukin-2 receptor subunit beta relationship: RO:0002104 PR:000001874 ! has plasma membrane part KLRB1-like protein relationship: RO:0002104 PR:000002065 ! has plasma membrane part mast/stem cell growth factor receptor relationship: RO:0002202 CL:0002344 ! develops from CD56-negative, CD161-positive immature natural killer cell, human property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-09-21T10:06:53Z [Term] id: CL:0002339 name: prostate stem cell def: "A prostate epithelial cell that is CD133-positive, CD44-positive, integrin A2beta3-high. This cell is a stem cell for the prostate epithelium." [GOC:tfm, PMID:15226377] subset: human_subset subset: mouse_subset synonym: "CD133-positive prostate epithelial cell" EXACT [] is_a: CL:0000048 ! multi fate stem cell is_a: CL:0002341 ! basal cell of prostate epithelium intersection_of: CL:0000034 ! stem cell intersection_of: BFO:0000050 UBERON:0002367 ! part of prostate gland property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-09-20T03:21:06Z [Term] id: CL:0002340 name: luminal cell of prostate epithelium def: "The exocrine cell of the prostate, this epithelial cell secretes prostatic acid phosphotase and PSA, and is dependent on androgen hormones for survival." [GOC:tfm] subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset is_a: CL:0002231 ! epithelial cell of prostate property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/2d-ftu/prostate-prostate-glandular-acinus/v1.2/assets/2d-ftu-prostate-prostate-glandular-acinus.png" xsd:string {terms:licence="http://creativecommons.org/licenses/by/4.0/", xref="doi:10.48539/HBM347.TXWZ.899"} property_value: RO:0002175 NCBITaxon:9606 property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0002340" xsd:string {name="luminal cell of prostate epithelium on CELLxGENE CellGuide"} property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 property_value: terms:description "Luminal cells of the prostate epithelium are secretory cells in the prostate gland, which is located around the urethra at the base of the bladder. In addition to luminal epithelial cells, the adult prostate contains basal epithelial cells and rare neuroendocrine cells, organized as a pseudostratified epithelium surrounded by stromal cells. The main function of the prostate is to nourish and protect sperm by secreting a slightly alkaline fluid which makes up approximately 30% of the semen. \nThe luminal epithelial cells form a single-layer lining in the prostate's acini. They have a polarized structure with the basal side attached to the basal lamina and the apical side facing the lumen. Specialized microvilli-like structures on the apical side aid in product secretion. Luminal cells express androgen receptors, making them sensitive to androgenic stimulation, which is crucial for regulating prostatic secretions and overall gland function.\nThe prostate's Luminal cells are responsible for producing and releasing prostatic fluid, which supports sperm post-ejaculation. They synthesize key proteins like prostate-specific antigen (PSA) and prostatic acid phosphatase. \nLuminal cells are also a focus of prostate cancer research as they are the putative cells-of-origin for the majority of prostate cancers. Overproliferation and persistent damage can lead to the initiation of carcinogenic events within these cells. The PSA produced by luminal cells is also a key biomarker for diagnosing, monitoring, and treating prostate cancer. As such, understanding the health and disease-related functions of these cells is essential for managing prostate conditions.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1016/j.cell.2014.08.017", xref="DOI:10.1016/j.celrep.2014.08.002", xref="DOI:10.1016/j.trecan.2018.09.003"} creation_date: 2010-09-20T03:34:05Z [Term] id: CL:0002341 name: basal cell of prostate epithelium def: "An undifferentiated cell of the prostate epithelium that lacks secretory activity." [GOC:tfm, PMCID:PMC2673349] subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset is_a: CL:0002231 ! epithelial cell of prostate property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/2d-ftu/prostate-prostate-glandular-acinus/v1.2/assets/2d-ftu-prostate-prostate-glandular-acinus.png" xsd:string {terms:licence="http://creativecommons.org/licenses/by/4.0/", xref="doi:10.48539/HBM347.TXWZ.899"} property_value: RO:0002175 NCBITaxon:9606 property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0002341" xsd:string {name="basal cell of prostate epithelium on CELLxGENE CellGuide"} property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 property_value: terms:description "Basal cells of the prostate epithelium are one of the major cell types found in the glandular part of the prostate, which is a small, walnut-shaped gland that produces seminal fluid in males. These cells are located at the base of the prostatic acinar epithelial layer and form a contiguous layer separating the acinar lumen, where the prostatic secretions coalesce, and the underlying connective tissue. In contrast to the luminal cells, basal cells lack secretory granules. In common with basal epithelial cells in other epithelia, prostatic basal cells express markers such as cytokeratin 14 and p63. \nA key function of the basal cells of the prostate epithelium is to provide structural support to the secretory luminal cells and contribute to maintaining the integrity of the epithelial layer. They also have unique regenerative properties that aid in the recovery of the glandular epithelium after injury. Under normal conditions, these cells remain quiescent, but upon injury, they proliferate to replace the damaged secretory luminal cells, indicating a stem/progenitor cell-like behavior. They also play an important role in serving as a reserve cell population helping in maintaining tissue homeostasis. \nBasal cells of prostate epithelium are also central to understanding the pathobiology of prostate diseases. They are typically absent in prostatic adenocarcinomas, the most common form of prostate cancer, but they are thought to play a critical yet complex role in oncogenesis and therapeutic resistance mechanisms of prostate cancer, and in benign prostatic hyperplasia. They also have the ability to differentiate into neuroendocrine cells or luminal cells under certain conditions, contributing to disease heterogeneity.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1016/j.celrep.2018.11.086", xref="DOI:10.1073/pnas.1320565110", xref="DOI:10.1080/15384101.2023.2206502", xref="DOI:10.1242/dev.01384", xref="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4219311/"} creation_date: 2010-09-20T03:34:10Z [Term] id: CL:0002342 name: circulating endothelial cell def: "A circulating endothelial cell of the phenotype CD146-positive, CD105-positive, CD45-negative. This cell type is indicative of recent vascular damage." [GOC:tfm, PMID:19652886] subset: human_subset subset: mouse_subset is_a: CL:0000115 ! endothelial cell property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-09-20T03:49:58Z [Term] id: CL:0002343 name: decidual natural killer cell, human def: "A natural killer cell subset that is found in the decidual of the uterus and is CD56-high, Galectin-1-positive and CD16-negative. This cell type represents the most abundant immune cell type in the decidual during the first trimester of pregnancy." [PMID:14568979, PMID:19800965] subset: cellxgene_subset subset: human_reference_atlas subset: human_subset synonym: "decidual NK cell" EXACT [] synonym: "dNK cell" EXACT [] is_a: CL:0000349 ! extraembryonic cell is_a: CL:0000824 ! mature natural killer cell is_a: CL:4052028 ! uterine natural killer cell intersection_of: CL:0000824 ! mature natural killer cell intersection_of: CL:4030046 PR:000001483 ! lacks_plasma_membrane_part low affinity immunoglobulin gamma Fc region receptor III intersection_of: RO:0002104 PR:000009766 ! has plasma membrane part galectin-1 intersection_of: RO:0002162 NCBITaxon:9606 ! in taxon Homo sapiens intersection_of: RO:0015015 PR:000001024 ! has high plasma membrane amount neural cell adhesion molecule 1 relationship: BFO:0000050 UBERON:0002450 ! part of decidua relationship: CL:4030046 PR:000001483 ! lacks_plasma_membrane_part low affinity immunoglobulin gamma Fc region receptor III relationship: RO:0002104 PR:000009766 ! has plasma membrane part galectin-1 relationship: RO:0002162 NCBITaxon:9606 ! in taxon Homo sapiens relationship: RO:0015015 PR:000001024 ! has high plasma membrane amount neural cell adhesion molecule 1 property_value: RO:0002175 NCBITaxon:9606 property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-09-20T04:00:02Z [Term] id: CL:0002344 name: CD56-negative, CD161-positive immature natural killer cell, human def: "A natural killer cell that is developmentally immature, has the phenotype CD34-negative, CD56-negative, CD117-positive, CD122-positive,and CD161-positive." [GO_REF:0000031, GOC:add, ISBN:0781735149, PMID:12457618] comment: Human markers; killer cell immunoglobulin-like receptor 2DL1 is used as a representative example (PRO at this time lacks a KIR superfamily). subset: human_subset synonym: "p-NK" RELATED [PMID:12457618] is_a: CL:0000823 ! immature natural killer cell intersection_of: CL:0000823 ! immature natural killer cell intersection_of: CL:4030046 PR:000001003 ! lacks_plasma_membrane_part CD34 molecule intersection_of: CL:4030046 PR:000001024 ! lacks_plasma_membrane_part neural cell adhesion molecule 1 intersection_of: RO:0002104 PR:000001381 ! has plasma membrane part interleukin-2 receptor subunit beta intersection_of: RO:0002104 PR:000001874 ! has plasma membrane part KLRB1-like protein intersection_of: RO:0002104 PR:000002065 ! has plasma membrane part mast/stem cell growth factor receptor intersection_of: RO:0002162 NCBITaxon:9606 ! in taxon Homo sapiens relationship: CL:4030046 PR:000001003 ! lacks_plasma_membrane_part CD34 molecule relationship: CL:4030046 PR:000001024 ! lacks_plasma_membrane_part neural cell adhesion molecule 1 relationship: RO:0002104 PR:000001381 ! has plasma membrane part interleukin-2 receptor subunit beta relationship: RO:0002104 PR:000001874 ! has plasma membrane part KLRB1-like protein relationship: RO:0002104 PR:000002065 ! has plasma membrane part mast/stem cell growth factor receptor relationship: RO:0002162 NCBITaxon:9606 ! in taxon Homo sapiens property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-09-20T04:33:11Z [Term] id: CL:0002345 name: CD27-low, CD11b-low immature natural killer cell, mouse def: "An immature natural killer cell that is NK1.1-positive, DX5-positive, Ly49-positive, CD27-low and CD11b-low. This cell type is found in high numbers in the liver." [GOC:tfm, http:www.immgen.org/index_content.html, PMID:19949422] comment: Markers are associated with mouse cells. subset: mouse_subset synonym: "preNK.BM" BROAD [] is_a: CL:0000823 ! immature natural killer cell intersection_of: CL:0000823 ! immature natural killer cell intersection_of: RO:0002104 PR:000001008 ! has plasma membrane part integrin alpha-2 intersection_of: RO:0002104 PR:000002977 ! has plasma membrane part killer cell lectin-like receptor subfamily B member 1C intersection_of: RO:0002104 PR:000009616 ! has plasma membrane part T-cell surface glycoprotein YE1/48 intersection_of: RO:0002162 NCBITaxon:10090 ! in taxon Mus musculus intersection_of: RO:0015016 PR:000001012 ! has low plasma membrane amount integrin alpha-M intersection_of: RO:0015016 PR:000001963 ! has low plasma membrane amount CD27 molecule relationship: RO:0002104 PR:000001008 ! has plasma membrane part integrin alpha-2 relationship: RO:0002104 PR:000002977 ! has plasma membrane part killer cell lectin-like receptor subfamily B member 1C relationship: RO:0002104 PR:000009616 ! has plasma membrane part T-cell surface glycoprotein YE1/48 relationship: RO:0002202 CL:0002346 ! develops from Dx5-negative, NK1.1-positive immature natural killer cell, mouse relationship: RO:0015016 PR:000001012 ! has low plasma membrane amount integrin alpha-M relationship: RO:0015016 PR:000001963 ! has low plasma membrane amount CD27 molecule property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-09-20T04:41:01Z [Term] id: CL:0002346 name: Dx5-negative, NK1.1-positive immature natural killer cell, mouse def: "An immature natural killer cell that is NK1.1-positive and DX-5 negative." [GOC:tfm, PMID:12766763] subset: mouse_subset is_a: CL:0000823 ! immature natural killer cell intersection_of: CL:0000823 ! immature natural killer cell intersection_of: CL:4030046 PR:000001008 ! lacks_plasma_membrane_part integrin alpha-2 intersection_of: RO:0002104 PR:000002977 ! has plasma membrane part killer cell lectin-like receptor subfamily B member 1C intersection_of: RO:0002162 NCBITaxon:10090 ! in taxon Mus musculus relationship: CL:4030046 PR:000001008 ! lacks_plasma_membrane_part integrin alpha-2 relationship: RO:0002104 PR:000002977 ! has plasma membrane part killer cell lectin-like receptor subfamily B member 1C relationship: RO:0002162 NCBITaxon:10090 ! in taxon Mus musculus property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-09-21T10:11:44Z [Term] id: CL:0002347 name: CD27-high, CD11b-high natural killer cell, mouse def: "A mature natural killer cell that is CD27-high and CD11b-high. This cell type is capable of interferon-gamma secretion." [GOC:tfm, PMID:19949422] subset: mouse_subset is_a: CL:0000824 ! mature natural killer cell intersection_of: CL:0000824 ! mature natural killer cell intersection_of: RO:0002162 NCBITaxon:10090 ! in taxon Mus musculus intersection_of: RO:0002215 GO:0032609 ! capable of type II interferon production intersection_of: RO:0015015 PR:000001012 ! has high plasma membrane amount integrin alpha-M intersection_of: RO:0015015 PR:000001963 ! has high plasma membrane amount CD27 molecule relationship: RO:0002202 CL:0002349 ! develops from CD27-high, CD11b-low natural killer cell, mouse relationship: RO:0015015 PR:000001012 ! has high plasma membrane amount integrin alpha-M relationship: RO:0015015 PR:000001963 ! has high plasma membrane amount CD27 molecule property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-09-21T10:19:49Z [Term] id: CL:0002348 name: CD27-low, CD11b-high natural killer cell, mouse def: "A CD27-low, CD11b-high natural killer cell that has a higher threshold of activation due to higher expression of inhibitory receptors." [GOC:tfm, PMID:1994922] subset: mouse_subset is_a: CL:0000824 ! mature natural killer cell intersection_of: CL:0000824 ! mature natural killer cell intersection_of: RO:0002162 NCBITaxon:10090 ! in taxon Mus musculus intersection_of: RO:0015015 PR:000001012 ! has high plasma membrane amount integrin alpha-M intersection_of: RO:0015016 PR:000001963 ! has low plasma membrane amount CD27 molecule relationship: RO:0002202 CL:0002347 ! develops from CD27-high, CD11b-high natural killer cell, mouse relationship: RO:0015015 PR:000001012 ! has high plasma membrane amount integrin alpha-M relationship: RO:0015016 PR:000001963 ! has low plasma membrane amount CD27 molecule property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-09-21T10:19:54Z [Term] id: CL:0002349 name: CD27-high, CD11b-low natural killer cell, mouse def: "A natural killer cell that is CD27-high and CD11b-low." [GOC:tfm, PMID:1994922] subset: mouse_subset is_a: CL:0000824 ! mature natural killer cell intersection_of: CL:0000824 ! mature natural killer cell intersection_of: RO:0002162 NCBITaxon:10090 ! in taxon Mus musculus intersection_of: RO:0015015 PR:000001963 ! has high plasma membrane amount CD27 molecule intersection_of: RO:0015016 PR:000001012 ! has low plasma membrane amount integrin alpha-M relationship: RO:0002202 CL:0002345 ! develops from CD27-low, CD11b-low immature natural killer cell, mouse relationship: RO:0015015 PR:000001963 ! has high plasma membrane amount CD27 molecule relationship: RO:0015016 PR:000001012 ! has low plasma membrane amount integrin alpha-M property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-09-21T10:20:00Z [Term] id: CL:0002350 name: endocardial cell alt_id: CL:1000475 def: "An endothelial cell that lines the intracavitary lumen of the heart, separating the circulating blood from the underlying myocardium. This cell type releases a number of vasoactive substances including prostacyclin, nitrous oxide and endothelin." [GOC:tfm, ISSN:0452-3458] subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "endocardial endothelial cell" EXACT [] synonym: "endothelial cell of endocardium" EXACT [FMA:75621] xref: FMA:75621 is_a: CL:0010008 ! cardiac endothelial cell intersection_of: CL:0000115 ! endothelial cell intersection_of: BFO:0000050 UBERON:0002165 ! part of endocardium relationship: BFO:0000050 UBERON:0002165 ! part of endocardium property_value: RO:0002175 NCBITaxon:9606 property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0002350" xsd:string {name="endocardial cell on CELLxGENE CellGuide"} property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 property_value: terms:description "Endocardial cells, often referred to as endothelial cells of the heart, constitute the innermost lining layer of the heart tissues, forming the endocardium. They play a critical role in maintaining heart functionality and homeostasis. These cells, flat and squamous in structure, are adjoined closely to form a tight barrier that separates the heart's muscular layer, the myocardium, from the blood flowing through the heart chambers.\nFunctionally, endocardial cells are key players in several crucial physiological processes within the heart. Synthesizing matrix molecules that contribute to the structural formation of the heart, these cells actively partake in maintaining its structural integrity. They also exhibit unique metabolic activity, which aids in maintaining optimal cardiac functioning in both healthy and pathological conditions. Importantly, they are known for their involvement in modulating myocardial contraction and relaxation, that is crucial for normal heart rhythm and function. They achieve this by producing factors like nitric oxide (NO) which, amongst other things, aids in the regulation of blood pressure, prevents blood clotting and inhibits the adherence of blood cells to the vessel wall.\nIn pathological states, endocardial cells can undergo a transformation process known as endothelial-mesenchymal transition (EndMT), which is inherently involved in several cardiac diseases. In this transition, they acquire the ability to migrate and differentiate into several other types of cells contributing to disease progression. Moreover, their dysfunction can lead to endocarditis, an inflammation of the endocardium, as well as increase the risk of other heart diseases.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1016/j.medici.2017.08.003", xref="DOI:10.1016/j.ydbio.2009.06.033", xref="DOI:10.1101/cshperspect.a036723", xref="DOI:10.1161/ATVBAHA.121.313788", xref="DOI:10.1161/CIRCRESAHA.117.312136"} creation_date: 2010-09-21T04:33:05Z [Term] id: CL:0002351 name: progenitor cell of endocrine pancreas def: "A progenitor cell that is able to differentiate into the pancreas alpha, beta and delta endocrine cells. This cell type expresses neurogenin-3 and Isl-1." [GOC:tfm, PMID:20025937, PMID:20217494, PMID:22728667] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "pancreatic endocrine progenitor" EXACT [] synonym: "pancreatic islet progenitor cell" EXACT [] is_a: CL:0011026 ! progenitor cell property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-09-21T04:41:06Z [Term] id: CL:0002352 name: gestational hematopoietic stem cell def: "A hematopoietic stem cell that exists during embryogenesis." [GOC:tfm, ISBN:978-60327-246-6] subset: human_subset subset: mouse_subset is_a: CL:0000037 ! hematopoietic stem cell intersection_of: CL:0000037 ! hematopoietic stem cell intersection_of: BFO:0000050 UBERON:0000922 ! part of embryo relationship: BFO:0000050 UBERON:0000922 ! part of embryo property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-09-22T09:05:13Z [Term] id: CL:0002353 name: fetal liver hematopoietic progenitor cell def: "A hematopoietic stem cell that resides in the fetal liver. In mice, this cell type is first observed at E10.5. This cell type is MHC-positive, HSA-positive, AA4.1-positive, CD45-positive, Sca-1 positive, CD150-positive, CD48-negative and CD244-negative." [GOC:tfm, ISBN:978-1-60327-346-6, PMID:16569764] subset: human_subset subset: mouse_subset is_a: CL:0002352 {is_inferred="true"} ! gestational hematopoietic stem cell intersection_of: CL:0002352 ! gestational hematopoietic stem cell intersection_of: CL:4030046 PR:000001308 ! lacks_plasma_membrane_part CD48 molecule intersection_of: CL:4030046 PR:000001896 ! lacks_plasma_membrane_part natural killer cell receptor 2B4 intersection_of: RO:0002104 GO:0042611 ! has plasma membrane part MHC protein complex intersection_of: RO:0002104 PR:000001006 ! has plasma membrane part receptor-type tyrosine-protein phosphatase C intersection_of: RO:0002104 PR:000001833 ! has plasma membrane part SLAM family member 1 intersection_of: RO:0002104 PR:000001932 ! has plasma membrane part signal transducer CD24 intersection_of: RO:0002104 PR:000002037 ! has plasma membrane part complement component C1q receptor intersection_of: RO:0002104 PR:000002979 ! has plasma membrane part lymphocyte antigen 6A-2/6E-1 relationship: BFO:0000050 UBERON:0002107 ! part of liver relationship: CL:4030046 PR:000001308 ! lacks_plasma_membrane_part CD48 molecule relationship: CL:4030046 PR:000001896 ! lacks_plasma_membrane_part natural killer cell receptor 2B4 relationship: RO:0002104 GO:0042611 ! has plasma membrane part MHC protein complex relationship: RO:0002104 PR:000001006 ! has plasma membrane part receptor-type tyrosine-protein phosphatase C relationship: RO:0002104 PR:000001833 ! has plasma membrane part SLAM family member 1 relationship: RO:0002104 PR:000001932 ! has plasma membrane part signal transducer CD24 relationship: RO:0002104 PR:000002037 ! has plasma membrane part complement component C1q receptor relationship: RO:0002104 PR:000002979 ! has plasma membrane part lymphocyte antigen 6A-2/6E-1 property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-09-22T09:08:32Z [Term] id: CL:0002354 name: yolk sac hematopoietic stem cell def: "A hematopoietic stem found in the yolk sac. In mice, this cell type is Sca-1-negative, CD45-negative, MHC-negative, HSA-positive, AA4.1-positive, CD44-positive." [doi:10.1097/MOH.0b013e3282f97ae1, GOC:tfm] subset: human_subset subset: mouse_subset synonym: "hemangioblast precursor" EXACT [] is_a: CL:0002352 {is_inferred="true"} ! gestational hematopoietic stem cell intersection_of: CL:0002352 ! gestational hematopoietic stem cell intersection_of: CL:4030046 GO:0042611 ! lacks_plasma_membrane_part MHC protein complex intersection_of: CL:4030046 PR:000001006 ! lacks_plasma_membrane_part receptor-type tyrosine-protein phosphatase C intersection_of: CL:4030046 PR:000002979 ! lacks_plasma_membrane_part lymphocyte antigen 6A-2/6E-1 intersection_of: RO:0002104 PR:000001307 ! has plasma membrane part CD44 molecule intersection_of: RO:0002104 PR:000001932 ! has plasma membrane part signal transducer CD24 intersection_of: RO:0002104 PR:000002037 ! has plasma membrane part complement component C1q receptor relationship: BFO:0000050 UBERON:0001040 ! part of yolk sac relationship: CL:4030046 GO:0042611 ! lacks_plasma_membrane_part MHC protein complex relationship: CL:4030046 PR:000001006 ! lacks_plasma_membrane_part receptor-type tyrosine-protein phosphatase C relationship: CL:4030046 PR:000002979 ! lacks_plasma_membrane_part lymphocyte antigen 6A-2/6E-1 relationship: RO:0002104 PR:000001307 ! has plasma membrane part CD44 molecule relationship: RO:0002104 PR:000001932 ! has plasma membrane part signal transducer CD24 relationship: RO:0002104 PR:000002037 ! has plasma membrane part complement component C1q receptor property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-09-22T09:08:34Z [Term] id: CL:0002355 name: primitive red blood cell def: "A large nucleated basophilic erythrocyte found in mammalian embryos. This cell type arises from the blood islands of yolk sacs and expresses different types of hemoglobins (beta-H1, gamma-1 and zeta) than adult erythrocytes. Considered a type of erythroblast as this cell type can enucleate in circulation." [DOI:10.1097/MOH.0b013e3282f97ae1, GOC:tfm, PMID:11495698] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "primitive erythroblast" EXACT [] synonym: "primitive erythrocyte" EXACT [] synonym: "primitive erythroid cell" EXACT [] is_a: CL:0002417 {is_inferred="true"} ! primitive erythroid lineage cell intersection_of: CL:0002417 ! primitive erythroid lineage cell intersection_of: BFO:0000050 UBERON:0000922 ! part of embryo intersection_of: BFO:0000051 PR:000008467 ! has part hemoglobin subunit zeta intersection_of: BFO:0000051 PR:000008857 ! has part hemoglobin subunit beta-1 intersection_of: RO:0000053 PATO:0000586 ! has characteristic increased size relationship: BFO:0000050 UBERON:0000922 ! part of embryo relationship: BFO:0000051 PR:000008467 ! has part hemoglobin subunit zeta relationship: BFO:0000051 PR:000008857 ! has part hemoglobin subunit beta-1 relationship: RO:0000053 PATO:0000586 ! has characteristic increased size relationship: RO:0002202 CL:0002361 ! develops from primitive erythroid progenitor property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-09-22T09:27:05Z [Term] id: CL:0002356 name: primitive reticulocyte def: "A primitive erythrocyte that has undergone enucleation. This cell type is 3-6 fold bigger than the fetal derived erythrocytes that they co-circulate with during fetal development. Expresses epsilon-gamma hemoglobin chains." [doi:10.1097/MOH.0b013e3282f97ae1, GOC:tfm, PMID:11495698] subset: human_subset subset: mouse_subset synonym: "megalocyte" EXACT [] is_a: CL:0002417 {is_inferred="true"} ! primitive erythroid lineage cell intersection_of: CL:0002417 ! primitive erythroid lineage cell intersection_of: RO:0000053 PATO:0000586 ! has characteristic increased size intersection_of: RO:0002202 CL:0002355 ! develops from primitive red blood cell relationship: RO:0000053 PATO:0000586 ! has characteristic increased size relationship: RO:0002202 CL:0002355 ! develops from primitive red blood cell property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-09-22T09:35:16Z [Term] id: CL:0002357 name: fetal derived definitive erythrocyte def: "A fetal liver derived enucleated erythrocyte. This erythrocyte resembles adult erythrocytes in that they are small (3- to 6- times smaller than primitive erythrocytes) and produce adult hemaglobins." [GOC:tfm, PMID:11495698] subset: human_subset subset: mouse_subset synonym: "macrocyte" EXACT [] is_a: CL:0000595 {is_inferred="true"} ! enucleate erythrocyte intersection_of: CL:0000595 ! enucleate erythrocyte intersection_of: BFO:0000050 UBERON:0000922 ! part of embryo intersection_of: BFO:0000051 PR:000008857 ! has part hemoglobin subunit beta-1 relationship: BFO:0000050 UBERON:0000922 ! part of embryo relationship: BFO:0000051 PR:000008857 ! has part hemoglobin subunit beta-1 relationship: RO:0002202 CL:0002353 ! develops from fetal liver hematopoietic progenitor cell property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-09-22T09:38:32Z [Term] id: CL:0002358 name: pyrenocyte def: "Derived from the Greek word pyren (the pit of a stone fruit), this is a transient nucleated cell type that results from exclusion of the nucleus from the primitive erythrocyte." [GOC:tfm] subset: human_subset subset: mouse_subset is_a: CL:0002417 {is_inferred="true"} ! primitive erythroid lineage cell intersection_of: CL:0002417 ! primitive erythroid lineage cell intersection_of: RO:0000053 PATO:0000587 ! has characteristic decreased size intersection_of: RO:0002202 CL:0002355 ! develops from primitive red blood cell relationship: RO:0000053 PATO:0000587 ! has characteristic decreased size relationship: RO:0002202 CL:0002355 ! develops from primitive red blood cell property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-09-22T10:02:37Z [Term] id: CL:0002359 name: placental hematopoietic stem cell def: "A hematopoietic stem cell of the placenta. This cell type is first observed E10.5 This cell type may give rise to fetal liver hematopoietic stem cells." [GOC:tfm, ISBN:978-1-60327-346-6] subset: human_subset subset: mouse_subset is_a: CL:0002352 ! gestational hematopoietic stem cell intersection_of: CL:0000037 ! hematopoietic stem cell intersection_of: BFO:0000050 UBERON:0001987 ! part of placenta relationship: BFO:0000050 UBERON:0001987 ! part of placenta property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-09-22T10:30:02Z [Term] id: CL:0002360 name: AGM hematopoietic stem cell def: "A hematopoietic stem cell from the aorta-gonad-mesonephros region of the developing embryo. First seen at E10.5 in mouse embryos. May give rise to fetal liver HSC." [GOC:tfm, ISBN:978-1-60327-346-6] subset: human_subset subset: mouse_subset is_a: CL:0002352 ! gestational hematopoietic stem cell property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-09-22T10:31:49Z [Term] id: CL:0002361 name: primitive erythroid progenitor def: "A progenitor cell that is capable of forming colonies of primitive erythrocytes in the blood island of the yolk sac. First arrive at E7.5 in mouse and expresses CD41." [GOC:tfm, ISBN:0813817986, PMID:20711979] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "EryP-CFC" EXACT [] synonym: "inner blood island hemangioblast" EXACT [] is_a: CL:0002417 {is_inferred="true"} ! primitive erythroid lineage cell intersection_of: CL:0002417 ! primitive erythroid lineage cell intersection_of: RO:0002104 PR:000009127 ! has plasma membrane part integrin alpha-IIb relationship: RO:0002104 PR:000009127 ! has plasma membrane part integrin alpha-IIb relationship: RO:0002202 CL:0002418 ! develops from hemangioblast property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-09-22T10:47:28Z [Term] id: CL:0002362 name: cerebellar granule cell precursor def: "A cell located in the outermost proliferative zone of the external germinal layer that can differentiate into astroglial cells and granule cells. This cell type is glial fibrillary acidic protein-positive and HNK1-positive." [GOC:tfm, PMID:14745007] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "GCP" RELATED OMO:0003000 [doi:10.3389/fncir.2020.611841] synonym: "granule cell precursor" BROAD [doi:10.3389/fncir.2020.611841] synonym: "granule cell progenitor" BROAD [doi:10.3389/fncir.2020.611841] is_a: CL:0000031 ! neuroblast (sensu Vertebrata) is_a: CL:0002319 ! neural cell relationship: BFO:0000050 UBERON:0009841 ! part of upper rhombic lip property_value: skos:prefLabel "cerebellar granule cell precursor" xsd:string property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-09-22T01:40:44Z [Term] id: CL:0002363 name: keratocyte def: "A keratocyte is a specialized fibroblast residing in the cornea stroma that has a flattened, dendritic morphology; located between the lamellae with a large flattened nucleus, and lengthy processes which communicate with neighboring cells. This corneal layer, representing about 85-90% of corneal thickness, is built up from highly regular collagenous lamellae and extracellular matrix components. Keratocytes play the major role in keeping it transparent, healing its wounds, and synthesizing its components. This cell type secretes collagen I, V, VI, and keratan sulfate." [GOC:tfm, ISBN:9780702029585] subset: cellxgene_subset subset: eye_upper_slim subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "corneal fibroblast" EXACT [] synonym: "corneal keratocyte" EXACT [] is_a: CL:0000005 ! neural crest derived fibroblast intersection_of: CL:0000057 ! fibroblast intersection_of: BFO:0000050 UBERON:0001777 ! part of substantia propria of cornea relationship: BFO:0000050 UBERON:0001777 ! part of substantia propria of cornea property_value: RO:0002175 NCBITaxon:9606 property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0002363" xsd:string {name="keratocyte on CELLxGENE CellGuide"} property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 property_value: terms:description "Keratocytes, also referred to as corneal fibroblasts, are specific cell types that primarily reside in the stromal layer of the cornea. Highly specialized, these cells play an essential role in the maintenance and repair of corneal tissue, thereby contributing to clear, distortion-free vision. As fibroblasts, their function often involves synthesis and secretion of the extracellular matrix, which gives the corneal stroma its structural integrity.\nKeratocytes are primarily responsible for the synthesis of collagen and proteoglycans, the principal components of the stromal extracellular matrix (ECM). The high optical clarity of the cornea is largely attributed to the unique arrangement of collagen fibrils, and keratocytes play a fundamental role in maintaining this arrangement. In response to corneal wounds or injuries, the keratocytes near the wound site become activated and undergo a transformation into a specialized phenotype, often referred to as repair keratocytes or activated keratocytes.\nDuring corneal repair, these activated keratocytes proliferate and migrate to the wound site, where they differentiate into myofibroblasts. Myofibroblasts play a significant role in wound contraction and synthesis of an alternative ECM required for wound closure. However, the overzealous activity of myofibroblasts can lead to corneal haze, a condition that impairs vision, and numerous studies suggest that optimal wound healing involves a delicate balance between repair and the pro-scar actions of myofibroblasts.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1016/j.biocel.2006.03.010", xref="DOI:10.1016/j.exer.2020.108228", xref="DOI:10.1038/s41598-019-53123-3", xref="DOI:10.1111/j.1463-5224.2009.00742.x"} creation_date: 2010-09-22T01:57:40Z [Term] id: CL:0002364 name: cortical thymic epithelial cell def: "An epithelial cell of the cortical portion of the thymus. Epithelial cells in this region are required for positive selection of CD8-positive T cells." [GOC:tfm, PMID:18403190] subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "cTEC" EXACT [] xref: BTO:0004562 is_a: CL:0002293 ! epithelial cell of thymus intersection_of: CL:0000066 ! epithelial cell intersection_of: BFO:0000050 UBERON:0002123 ! part of cortex of thymus relationship: BFO:0000050 UBERON:0002123 ! part of cortex of thymus property_value: RO:0002175 NCBITaxon:9606 property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0002364" xsd:string {name="cortical thymic epithelial cell on CELLxGENE CellGuide"} property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 property_value: terms:description "Cortical thymic epithelial cells (cTECs) are a vital cell type located in the thymus, a lymphoid organ that plays a key role in the development of T cells, which are essential for the adaptive immune system. cTECs also have a role in forming barriers and lining surfaces. In the thymus, their presence contributes to the distinctive architecture of both the cortex and medulla.\ncTECs also play a significant part in the selection and development of T cells. During T cell maturation, these cells express both self and non-self proteins via the major histocompatibility complex (MHC) to immature T cells. cTECs then stimulate the T cells that can recognize such proteins, an important event known as positive selection. This process aids in the creation of a diverse T cell receptor (TCR) repertoire that can react to a wide range of antigens, therefore ensuring effective immunity. \nApart from aiding in T cells' positive selection, cTECs also contribute to eliminating self-reactive T cells, a role essential in preventing autoimmune diseases. These cells induce an apoptosis-driven process known as \"negative selection\" which eliminates T cells that are too highly reactive to self-antigens.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1016/bs.ai.2014.09.003", xref="DOI:10.1038/nri3667", xref="DOI:10.1111/sji.13094"} creation_date: 2010-09-23T03:17:12Z [Term] id: CL:0002365 name: medullary thymic epithelial cell def: "An epithelial cell of the medullary thymus. This cell type expresses a diverse range of tissue-specific antigens. This promiscuous gene expression is a cell-autonomous property of medullary epithelial cells and is maintained during the entire period of thymic T cell output." [GOC:tfm, PMID:18180458] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "mTEC" EXACT [] xref: BTO:0004563 is_a: CL:0002293 ! epithelial cell of thymus intersection_of: CL:0000066 ! epithelial cell intersection_of: BFO:0000050 UBERON:0002124 ! part of medulla of thymus relationship: BFO:0000050 UBERON:0002124 ! part of medulla of thymus property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/2d-ftu/thymus-thymus-lobule/v1.3/assets/2d-ftu-thymus-thymus-lobule.png" xsd:string {terms:licence="http://creativecommons.org/licenses/by/4.0/", xref="doi:10.48539/HBM322.LZLG.752"} property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0002365" xsd:string {name="medullary thymic epithelial cell on CELLxGENE CellGuide"} property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 property_value: terms:description "Medullary thymic epithelial cells (mTECs) are distinct cells situated in the thymic medulla, a vital organ where T cells mature. mTECs are recognized by their unique appearance, characterized by large, plump cells with abundant cytoplasm and irregularly shaped nuclei. They inhabit a microenvironment closely interacting with various thymic cell types, including conventional dendritic cells and thymocytes.\nThe primary function of mTECs revolves around negative selection of developing T cells, thus preventing autoimmune responses. mTECs allow developing T cells to recognize and be responsive to foreign antigens while remaining tolerant to the body's own tissues. They achieve this through a process called promiscuous gene expression where they express and display a vast array of self-antigens. This process is regulated by a transcriptional regulator called autoimmune regulator (Aire), which contributes to immunological self-tolerance.\nmTECs themselves have a self-renewing ability and sustain the continuous export of mature T cells. They also express a number of genes that encode for chemokines and other signaling molecules which draw in and retain developing T cells for the process of negative selection. The three-dimensional network formed by these cells provides a physical platform for such selection. Together, mTECs hold a critical place in the maintenance of immune homeostasis, demonstrating the conceptual links that exist between population of stromal cells, thymocytes development, tissue-restricted antigen expression, and negative selection.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1007/s11427-013-4482-4", xref="DOI:10.4049/jimmunol.2100692", xref="DOI:10.7554/eLife.60188"} creation_date: 2010-09-23T03:17:14Z [Term] id: CL:0002366 name: myometrial cell def: "A smooth muscle cell of the myometrium that enlarges and stretches during pregnancy, and contracts in response to oxytocin." [GOC:tfm, PMID:11429640] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "myometrium smooth muscle cell" EXACT [] xref: BTO:0004519 is_a: CL:0002601 ! uterine smooth muscle cell intersection_of: CL:0000192 ! smooth muscle cell intersection_of: BFO:0000050 UBERON:0001296 ! part of myometrium relationship: BFO:0000050 UBERON:0001296 ! part of myometrium property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0002366" xsd:string {name="myometrial cell on CELLxGENE CellGuide"} property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 property_value: terms:description "Myometrial cells are specialized smooth muscle cells located in the myometrium, the middle layer of the uterine wall. Unique to female reproductive physiology, they play a key role in pregnancy and childbirth. \nThese cells are distinctive in their capability to substantially increase in size and number during pregnancy, preparing the uterus to accommodate the growing fetus. As pregnancy progresses, myometrial cells demonstrate a progressive growth in uterine mass through cellular hypertrophy. They are also responsible for the production of extracellular matrix proteins like collagen, which aids in supporting cell structure and function, further facilitating uterine enlargement.\nDuring childbirth, myometrial cells are responsible for the expansion and contraction of the uterus. They can propagate action potentials and generate considerable force, which is critical to their function in the reproductive system. After pregnancy, these cells can reduce in size, a process known as uterine involution. Given the important role these cells play in female reproductive physiology, dysregulation of the myometrial cell function can contribute to uterine pathologies such as uterine fibroids.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1073/pnas.070447210", xref="DOI:10.1093/humupd/dmr031", xref="DOI:10.1177/1535370220938741", xref="https://www.sciencedirect.com/topics/medicine-and-dentistry/uterine-contraction", xref="https://www.sciencedirect.com/topics/veterinary-science-and-veterinary-medicine/myometrium"} creation_date: 2010-09-23T03:46:34Z [Term] id: CL:0002367 name: trabecular meshwork cell def: "An ocular connective tissue cell that is part of the eye's trabecular meshwork and is directly responsible for regulating the outflow of aqueous humor from the anterior chamber of the eye, thereby maintaining proper intraocular pressure." [GOC:tfm, PMID:14500801, PMID:40136401] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "trabeculocyte" EXACT [] is_a: CL:0002320 {is_inferred="true"} ! connective tissue cell intersection_of: CL:0002320 ! connective tissue cell intersection_of: BFO:0000050 UBERON:0005969 ! part of eye trabecular meshwork relationship: BFO:0000050 UBERON:0005969 ! part of eye trabecular meshwork property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-09-23T04:18:50Z [Term] id: CL:0002368 name: respiratory tract epithelial cell def: "An epithelial cell of the respiratory tract epithelium. These cells have an endodermal origin." [GOC:tfm] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "airway epithelial cell" EXACT [] synonym: "respiratory epithelial cell" EXACT [] xref: BTO:0004533 is_a: CL:0002076 ! endo-epithelial cell intersection_of: CL:0000066 ! epithelial cell intersection_of: BFO:0000050 UBERON:0004802 ! part of respiratory tract epithelium relationship: BFO:0000050 UBERON:0004802 ! part of respiratory tract epithelium property_value: skos:prefLabel "respiratory tract epithelial cell" xsd:string property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-09-23T04:38:49Z [Term] id: CL:0002369 name: fungal spore def: "A differentiated form of a fungus produced during or as a result of an asexual or sexual reproductive process; usually a cell with a thick cell wall that stores and protects one or more nuclei. Spores may be produced in response to, and are characteristically resistant to, adverse environmental conditions." [FAO:0000019, GOC:tfm] xref: MESH:D013172 is_a: CL:0000521 ! fungal cell property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-10-01T09:02:42Z [Term] id: CL:0002370 name: respiratory tract goblet cell def: "A simple columnar epithelial cell that secretes mucin. Rough endoplasmic reticulum, mitochondria, the nucleus, and other organelles are concentrated in the basal portion. The apical plasma membrane projects microvilli to increase surface area for secretion." [GOC:tfm, ISBN:0721662544] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "respiratory goblet cell" EXACT [] synonym: "respiratory mucosa goblet cells" EXACT [MP:0010863] is_a: CL:0000160 ! goblet cell is_a: CL:0008055 ! respiratory tract secretory epithelial cell intersection_of: CL:0000160 ! goblet cell intersection_of: BFO:0000050 UBERON:0004802 ! part of respiratory tract epithelium property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0002370" xsd:string {name="respiratory tract goblet cell on CELLxGENE CellGuide"} property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 property_value: terms:description "The respiratory goblet cell is a highly specialized cell type found primarily within the respiratory tract, including the nose, trachea, and lungs. Named because their shape resembles a goblet - a drinking vessel with a wide body and narrow neck - these cells form a vital part of the respiratory system's protective mechanisms. They are found within the columnar epithelium lining these organs, which forms a barrier between the internal body and the exterior environment.\nA principal function of the respiratory goblet cell is the production and secretion of mucus, a carbohydrate-rich, viscous and gel-like substance that plays a critical role in trapping dust, bacteria, viruses, and other airborne particles that are inhaled. The mucus secreted by the goblet cells covers the lining of the respiratory tract, effectively catching these particles and preventing them from reaching the lungs and causing infection. Mucus also provides hydration and lubrication to the respiratory tract surfaces, which is important in maintaining the tissue's health and functioning.\nIn addition to their mucus-secreting capabilities, respiratory goblet cells also play a significant role in the body's inflammatory responses. When the respiratory system is exposed to irritants or pathogens, the number and activity of goblet cells often increase, leading to a higher production of mucus. This is a protective response designed to trap and neutralize the harmful substances more effectively. However, in conditions like chronic obstructive pulmonary disease (COPD) and asthma, an overproliferation of goblet cells, also known as goblet cell hyperplasia, can lead to excessive mucus production and airway obstruction.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1016/S1357-2725(02)00083-3", xref="DOI:10.1111/febs.15731", xref="DOI:10.1165/ajrcmb.25.5.f218", xref="DOI:10.2147/COPD.S38938", xref="DOI:10.3109/01902148.2013.791733"} creation_date: 2010-09-23T04:42:27Z [Term] id: CL:0002371 name: obsolete somatic cell def: "OBSOLETE. A cell of an organism that does not pass on its genetic material to the organism's offspring (i.e. a non-germ line cell)." [GOC:tfm, ISBN:0721662544] subset: ubprop:upper_level xref: BTO:0001268 xref: FMA:72300 xref: WBbt:0008378 property_value: IAO:0000233 https://github.com/obophenotype/cell-ontology/issues/1150 property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0002371" xsd:string {name="obsolete somatic cell on CELLxGENE CellGuide"} property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 property_value: terms:description "Somatic cells represent the majority of the cell types in the human body. They are fundamental building blocks of organs, tissues, and other bodily structures, with every organ being composed of distinct subpopulations of these cells. \nThe primary function of somatic cells is to maintain the function and survival of an organism. They carry significant information in the form of DNA, and through the process of mitosis, contribute to the repair and regeneration of body tissues.\nFurther, some types of somatic cells work in a collaborative manner to form complex functional structures such as the skin and lining of the gut, demonstrating a higher level of organization. However, it's important to note that somatic cells are distinct from germ cells, which are responsible for sexual reproduction by forming sperm or eggs. Any alterations in the DNA of somatic cells, due to mutations, will not affect the offspring as they aren't involved in transmission of genetic information to the next generation. \nWhile most somatic cells contain two copies of each chromosome (diploid), a certain subset may possess a single set of chromosomes (haploid), specifically found in male ants, bees, and other hymenopterans. Hence, diversity is a defining characteristic of somatic cells, reflecting in their structures, roles, and genetic makeup.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1038/nrm3980", xref="https://www.genome.gov/genetics-glossary/Somatic-Cells", xref="https://www.ncbi.nlm.nih.gov/books/NBK557896/"} is_obsolete: true replaced_by: CL:0000000 creation_date: 2010-09-24T09:44:42Z [Term] id: CL:0002372 name: myotube alt_id: CL:0000369 def: "A transversely striated, multinucleated syncytial muscle cell, formed by the fusion of myoblasts during muscle development." [GOC:dos, GOC:tfm, ISBN:0323052908, PMID:22274696] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "myofiber" EXACT [FBbt:00005812] synonym: "myofibril" EXACT [FBbt:00005812] xref: FBbt:00005812 {sssom:mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"} is_a: CL:0000737 ! striated muscle cell is_a: CL:4052002 ! syncytial cell intersection_of: CL:0000187 ! muscle cell intersection_of: BFO:0000051 GO:0030017 ! has part sarcomere intersection_of: RO:0000053 PATO:0001908 ! has characteristic multinucleate intersection_of: RO:0000053 PATO:0002478 ! has characteristic transversely striated relationship: RO:0000053 PATO:0002478 ! has characteristic transversely striated property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0002372" xsd:string {name="myotube on CELLxGENE CellGuide"} property_value: skos:prefLabel "myotube" xsd:string property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 property_value: terms:description "Myotubes are multinucleated cells and are categorized under the umbrella of skeletal muscle cells. They are formed through an intricate process known as myogenesis, which is a part of skeletal muscle development. It is vital to note that myotubes are not terminally differentiated but are precursors to mature muscle fiber cells.\nMyotubes come to life through the fusion of myoblasts, which are undifferentiated mononucleated progenitor cells. In the early stages of embryonic muscle development, myoblasts proliferate rapidly under the influence of growth and differentiation factors. As myoblasts reach confluence, they withdraw from the cell cycle, align themselves with each other, increase expression of muscle-specific proteins, and ultimately fuse to form myotubes. The formation of myotubes heralds a critical transition, as this is when cells shift from proliferation and growth to differentiation and maturation.\nFunctionally, myotubes play a critical role in the formation and development of skeletal muscles. Myotubes gradually grow in size through the incorporation of additional myoblasts and eventually mature into muscle fibers, the contractile units of skeletal muscles. During this maturation process, myotubes polymerize their soluble muscle-specific proteins into myofibrils, which are essential for muscle contraction. Overall, myotubes are vital players in the complex process of muscle development and homeostasis.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1007/s10544-012-9709-9", xref="https://www.ncbi.nlm.nih.gov/books/NBK10006", xref="https://www.sciencedirect.com/topics/medicine-and-dentistry/myotube"} creation_date: 2010-09-24T01:13:01Z [Term] id: CL:0002373 name: growth hormone releasing hormone secreting cell def: "A peptide hormone secreting cell that secretes growth hormone releasing hormone." [GOC:dph, GOC:tfm] subset: human_subset subset: mouse_subset synonym: "GHRH secreting cell" EXACT [] synonym: "somatocrinin secreting cell" EXACT [] is_a: CL:0000167 ! peptide hormone secreting cell property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-09-24T01:36:44Z [Term] id: CL:0002374 name: ear hair cell def: "A hair cell of the ear that contains the organs of balance and hearing." [GOC:dph, GOC:tfm, ISBN:0192801023] subset: human_subset subset: mouse_subset synonym: "ear receptor cell" EXACT [] is_a: CL:0000006 ! neuronal receptor cell is_a: CL:0000855 ! sensory hair cell intersection_of: CL:0000855 ! sensory hair cell intersection_of: BFO:0000050 UBERON:0001690 ! part of ear relationship: BFO:0000050 UBERON:0001690 ! part of ear property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-09-24T01:49:31Z [Term] id: CL:0002375 name: Schwann cell precursor def: "A multipotent progenitor cell that develops from a migratory neural crest cell. The schwann cell precursor is embedded among axons, with minimal extracellular space separating them from nerve cell membranes. This cell lacks a basal lamina, which distinguishes it from more mature Schwann cells. In rodents, cadherin-19 (Cdh19) serves as a specific marker for this developmental stage." [GOC:tfm, PMID:15580626, PMID:30971890, PMID:35815410] comment: Schwann cell precursor are capable of differentiating into Schwann cells and other cell types such as melanocytes, neurons, and mesenchymal cells. {xref="PMID:35815410"} subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "Schwann cell precursor cell" EXACT [] synonym: "SCP" RELATED OMO:0003000 [PMID:35815410] is_a: CL:0011026 ! progenitor cell relationship: RO:0000053 PATO:0001402 ! has characteristic multipotent relationship: RO:0002202 CL:0000333 ! develops from migratory neural crest cell relationship: RO:0002387 CL:0002573 ! has potential to develop into Schwann cell property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0002375" xsd:string {name="Schwann cell precursor on CELLxGENE CellGuide"} property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 property_value: terms:description "Schwann cell precursors are a crucial type of cell in the peripheral nervous system, derived from the neural crest during embryogenesis. The primary function of Schwann cell precursors is to differentiate into either myelinating or non-myelinating Schwann cells, both of which are critical in the proper function of the nervous system: myelinating Schwann cells cover axons in a myelin sheath, which allows for quicker and more efficient conduction of nerve signals, while non-myelinating Schwann cells envelope several axons together, effectively aiding slower nerve conduction. \nSchwann cell precursors are also possibly involved in guiding axonal growth during the early development of the nervous system, and they have an inherent potential to form other cell types such as melanocytes, parasympathetic neurons, and endoneurial fibroblasts. \nGrowing evidence suggests that there is high plasticity among Schwann cell precursor derivatives during postnatal development and that they play a dynamic role not only in the development of the nervous system but also in its repair and regeneration post injury.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1016/j.cdev.2021.203686", xref="DOI:10.3389/fnmol.2019.00069", xref="DOI:10.3390/cells11233753"} creation_date: 2010-09-24T02:06:10Z [Term] id: CL:0002376 name: non-myelinating Schwann cell def: "A glial cell that ensheaths multiple small diameter axons in the peripheral nervous system. The non-myelinating Schwann cell is embedded among neurons (axons) with minimal extracellular spaces separating them from nerve cell membranes and has a basal lamina. Cells can survive without an axon present. These cells can de-differentiate into immature Schwann cells." [GOC:cvs, GOC:tfm, ISBN:0721662544] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "Schwann cell" BROAD [] is_a: CL:0002573 ! Schwann cell relationship: RO:0002202 CL:0002377 ! develops from immature Schwann cell property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-09-24T02:10:26Z [Term] id: CL:0002377 name: immature Schwann cell def: "A glial cell that develops from a Schwann cell precursor. The immature Schwann cell is embedded among neurons (axons) with minimal extracellular spaces separating them from nerve cell membranes and has a basal lamina. Cells can survive without an axon present. Immature Schwann cell can be found communally ensheathing large groups of axons." [GOC:cvs, GOC:tfm, ISBN:0721662544] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "Schwann cell" BROAD [] xref: ZFA:0001725 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0002573 ! Schwann cell relationship: RO:0002202 CL:0002375 ! develops from Schwann cell precursor property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0002377" xsd:string {name="immature Schwann cell on CELLxGENE CellGuide"} property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 property_value: terms:description "The immature Schwann cell is a distinctive, developmental stage in the life cycle of a Schwann cell, which is a type of glial cell that is essential for the formation and maintenance of the myelin sheaths that coat and insulate the axons of neurons, boosting their electrical conducting abilities.\nThe immature Schwann cell represents a transitional phase between the immature, proliferative Schwann cell progenitors and the mature, myelinating Schwann cells. The transition to a mature, fully differentiated state happens under the influence of axonal signals and involves significant changes in gene expression; immature Schwann cells are characterized by specific factors including the expression of the S100 protein, a unique marker that differentiates Schwann cells from other glial cells. \nImmature Schwann cells have the potential for extensive proliferation, and they actively interact with axons. During the period of synaptic refinement in development, they can respond to neuronal activity and participate in radial sorting of axons. At the same time, immature Schwann cells further modulate the microenvironment, which helps define axonal diameters and spaces.\nWhile immature Schwann cells contribute to the initial development and refinement of neural circuits, their maturation to myelinating Schwann cells is vital for the efficient functioning of the mature peripheral nervous system.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1016/j.cdev.2021.203686", xref="DOI:10.1101/cshperspect.a020487", xref="DOI:10.1177/1073858415572361", xref="DOI:10.1371/journal.pone.0123278", xref="DOI:10.4103/1673-5374.211172"} creation_date: 2010-09-24T02:10:31Z [Term] id: CL:0002378 name: immature Vgamma2-positive fetal thymocyte def: "A double negative thymocyte that has a T cell receptor consisting of a gamma chain containing a Vgamma2 segment, and a delta chain. This cell type is CD4-negative, CD8-negative and CD24-positive and is found in the fetal thymus." [GOC:tfm, http://www.immgen.org] comment: NOTE: currently variable immune gene segments are not represented in the OBO Foundry. Cross-product definitions were not made as a result. Also, there are three different nomenclatures for the variable gamma segments. subset: human_subset subset: mouse_subset synonym: "fetal Vgamma2+ thymocyte" BROAD [] is_a: CL:0002404 ! fetal thymocyte property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-10-07T02:21:07Z [Term] id: CL:0002379 name: meningothelial cell def: "A neurecto-epithelial cell found in the arachnoid villi of dura mater. This cell type facilitates flow of cerebrospinal fluid into the blood." [GOC:tfm, http://www.aippg.net/forum/viewtopic.php?t=62590] subset: human_subset subset: mouse_subset synonym: "arachnoid cap cell" EXACT [] xref: FMA:86588 is_a: CL:0000710 ! neurecto-epithelial cell property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-09-28T02:23:46Z [Term] id: CL:0002380 name: oospore def: "An asexual spore formed by Oomycetes; formed upon fertilization of an oosphere." [GOC:tfm, ISBN:0851988857, SGD:clt] xref: FAO:0000039 is_a: CL:0000605 ! fungal asexual spore property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-10-01T09:22:45Z [Term] id: CL:0002381 name: uninucleate conidium def: "A conidium that has only one nucleus." [GOC:tfm, SGD:clt] xref: FAO:0000025 is_a: CL:0000599 ! conidium property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-10-01T09:26:39Z [Term] id: CL:0002382 name: multinucleate conidium def: "A conidium that has more than one nucleus." [GOC:tfm, SGD:clt] xref: FAO:0000033 is_a: CL:0000599 ! conidium property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-10-01T09:31:28Z [Term] id: CL:0002383 name: conidium of conidiophore head def: "A uninucleate spore formed on specialized cells or projections, sterigma, of a conidiophore head." [GOC:tfm, PMID:9529886, SGD:clt] xref: FAO:0000033 is_a: CL:0002381 ! uninucleate conidium [Term] id: CL:0002384 name: uninucleate macroconidium def: "A macroconidium that has only one nucleus." [GOC:tfm, SGD:clt] xref: FAO:0000029 is_a: CL:0000606 ! macroconidium is_a: CL:0002381 ! uninucleate conidium [Term] id: CL:0002385 name: blastoconidium def: "An oblong or round asexual spore formed from conidial chains." [GOC:tfm, PMID:2524423, SGD:clt] synonym: "blastospore" RELATED [] xref: BTO:0000127 xref: FAO:0000042 is_a: CL:0000606 ! macroconidium [Term] id: CL:0002386 name: multinucleate macroconidium def: "A macroconidium that has more than one nucleus." [GOC:tfm, SGD:clt] xref: FAO:0000035 is_a: CL:0000606 ! macroconidium is_a: CL:0002382 ! multinucleate conidium [Term] id: CL:0002387 name: arthroconidium def: "Cylindrical spore formed by development and compartmentation of hyphae; the hyphae are often supporting blastoconidiophores." [GOC:tfm, PMID:2524423, SGD:clt] synonym: "arthrospore" RELATED [] xref: FAO:0000041 is_a: CL:0000606 ! macroconidium [Term] id: CL:0002388 name: multinucleate arthroconidium def: "An arthroconidium that has more than one nucleus." [GOC:tfm, SGD:clt] xref: FAO:0000037 is_a: CL:0002386 ! multinucleate macroconidium is_a: CL:0002387 ! arthroconidium [Term] id: CL:0002389 name: uninucleate arthroconidium def: "An arthroconidium that has only one nucleus." [GOC:tfm, SGD:clt] xref: FAO:0000031 is_a: CL:0002384 ! uninucleate macroconidium is_a: CL:0002387 ! arthroconidium [Term] id: CL:0002390 name: uninucleate blastconidium def: "A blastoconidium that has only one nucleus." [GOC:tfm, SGD:clt] xref: FAO:0000030 is_a: CL:0002384 ! uninucleate macroconidium is_a: CL:0002385 ! blastoconidium [Term] id: CL:0002391 name: multinucleate blastoconidium def: "A blastoconidium that has more than one nucleus." [GOC:tfm, SGD:clt] xref: FAO:0000036 is_a: CL:0002385 ! blastoconidium is_a: CL:0002386 ! multinucleate macroconidium [Term] id: CL:0002392 name: obsolete plant spore def: "Obsolete. Use PO:0025017 from Plant Ontology instead. A plant cell that arises through meiosis and develops into a gametophyte." [GOC:tfm, PO:0025017] is_obsolete: true replaced_by: PO:0025017 [Term] id: CL:0002393 name: intermediate monocyte def: "A monocyte that has characteristics of both patrolling and inflammatory monocytes." [GOC:tfm, PMID:20628149, PMID:20870168] subset: cellxgene_subset subset: human_subset subset: mouse_subset is_a: CL:0000576 ! monocyte intersection_of: CL:0000576 ! monocyte intersection_of: CL:4030044 GO:0030224 ! has_not_completed monocyte differentiation intersection_of: CL:4030046 PR:000001002 ! lacks_plasma_membrane_part CD19 molecule intersection_of: CL:4030046 PR:000001020 ! lacks_plasma_membrane_part CD3 epsilon intersection_of: CL:4030046 PR:000001199 ! lacks_plasma_membrane_part C-C chemokine receptor type 2 intersection_of: CL:4030046 PR:000001289 ! lacks_plasma_membrane_part membrane-spanning 4-domains subfamily A member 1 relationship: CL:4030044 GO:0030224 ! has_not_completed monocyte differentiation relationship: CL:4030046 PR:000001002 ! lacks_plasma_membrane_part CD19 molecule relationship: CL:4030046 PR:000001020 ! lacks_plasma_membrane_part CD3 epsilon relationship: CL:4030046 PR:000001199 ! lacks_plasma_membrane_part C-C chemokine receptor type 2 relationship: CL:4030046 PR:000001289 ! lacks_plasma_membrane_part membrane-spanning 4-domains subfamily A member 1 relationship: RO:0002202 CL:0000860 ! develops from classical monocyte property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0002393" xsd:string {name="intermediate monocyte on CELLxGENE CellGuide"} property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 property_value: terms:description "Intermediate monocytes, also defined as CD14++CD16+ monocytes, constitute one of the three subsets of human monocytes which also include classical and non-classical monocytes. These cells play a crucial role in the physiological function of the immune system and are particularly significant in the human body's response to inflammation and infection. With a diverse array of functions, intermediate monocytes uniquely contribute to the immune response potency by bridging the gap between the classical and non-classical monocyte subsets.\nIntermediate monocytes exhibit a combined functionality of the two other subsets in terms of their phenotypic characteristics, functional capabilities and gene expression profiles. They express high levels of CD14 (like classical monocytes) and also express CD16 (like non-classical monocytes). These monocytes generally release lower amounts of cytokines compared to classical and non-classical monocytes, but produce the most reactive oxygen species. Intermediate monocytes may also induce T cell proliferation and express high levels of major histocompatibility complex molecules for antigen presentation.\nThe relative number of intermediate monocytes in the bloodstream increases under conditions of severe inflammation and infection, although their roles have not yet been clearly defined. Additionally, some studies reported findings on monocytes with a combined population of intermediate and non-classical monocytes, further complicating the understanding of the function of these cells.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1182/blood-2010-02-258558", xref="DOI:10.1182/blood-2010-12-326355", xref="DOI:10.2147/JIR.S292513"} creation_date: 2010-10-04T10:52:03Z [Term] id: CL:0002394 name: CD141-positive myeloid dendritic cell def: "A myeloid dendritic cell found in the blood, lymph nodes, tonsil, bone marrow, and spleen that is CD141-positive (BDCA-3), XCR1-positive, and Clec9A-positive. This cell-type can cross-present antigen to CD8-positive T cells and can produce inteferon-beta." [GOC:dsd, GOC:tfm, PMCID:PMC2882828, PMCID:PMC2882837, PMID:17332250, PMID:20628149] comment: Markers are found in human cells. Normally they represent 3-5% of peripheral blood mDCs (human). These cells express high levels of CD283 (TLR3), are capable of producing IL-12p70 and IFN-beta upon stimulation, and inducing a TH1 response [PMCID:PMC2882828]. They are also Necl2-positive. May be human equivalent of murine CD8-alpha-positive DCs. subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset is_a: CL:0000782 {is_inferred="true"} ! myeloid dendritic cell is_a: CL:0000784 ! plasmacytoid dendritic cell intersection_of: CL:0000782 ! myeloid dendritic cell intersection_of: RO:0002104 PR:000002105 ! has plasma membrane part thrombomodulin intersection_of: RO:0002215 GO:0002827 ! capable of positive regulation of T-helper 1 type immune response intersection_of: RO:0002215 GO:0032606 ! capable of type I interferon production intersection_of: RO:0002215 GO:0042590 ! capable of antigen processing and presentation of exogenous peptide antigen via MHC class I relationship: RO:0002104 PR:000002105 ! has plasma membrane part thrombomodulin relationship: RO:0002215 GO:0002827 ! capable of positive regulation of T-helper 1 type immune response relationship: RO:0002215 GO:0042590 ! capable of antigen processing and presentation of exogenous peptide antigen via MHC class I property_value: RO:0002175 NCBITaxon:9606 property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-10-04T02:38:58Z [Term] id: CL:0002395 name: Gr1-high classical monocyte def: "A resident monocyte that is Gr-1 high, CD43-negative, CX3CR1-negative, CD115-positive, and B220-negative." [GOC:tfm, http://www.immgen.org/index_content.html, PMID:20628149, PMID:27098205, PMID:8890901] comment: Markers are associated with mice. The Gr epitope is used to describe this cell type is found on both Ly6c and Ly6g. However, its the Ly6c that is considered the specific marker, and thus used in the cross-product. subset: mouse_subset is_a: CL:0000860 {is_inferred="true"} ! classical monocyte is_a: CL:0001022 ! CD115-positive monocyte intersection_of: CL:0000860 ! classical monocyte intersection_of: CL:4030046 PR:000001014 ! lacks_plasma_membrane_part receptor-type tyrosine-protein phosphatase C isoform CD45RABC intersection_of: CL:4030046 PR:000001206 ! lacks_plasma_membrane_part CX3C chemokine receptor 1 intersection_of: CL:4030046 PR:000001879 ! lacks_plasma_membrane_part leukosialin intersection_of: RO:0002104 PR:000001012 ! has plasma membrane part integrin alpha-M intersection_of: RO:0002104 PR:000002062 ! has plasma membrane part macrophage colony-stimulating factor 1 receptor intersection_of: RO:0002162 NCBITaxon:10090 ! in taxon Mus musculus intersection_of: RO:0015015 PR:000002980 ! has high plasma membrane amount lymphocyte antigen 6C2 relationship: CL:4030046 PR:000001014 ! lacks_plasma_membrane_part receptor-type tyrosine-protein phosphatase C isoform CD45RABC relationship: CL:4030046 PR:000001206 ! lacks_plasma_membrane_part CX3C chemokine receptor 1 relationship: CL:4030046 PR:000001879 ! lacks_plasma_membrane_part leukosialin relationship: RO:0002162 NCBITaxon:10090 ! in taxon Mus musculus relationship: RO:0015015 PR:000002980 ! has high plasma membrane amount lymphocyte antigen 6C2 property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-10-04T11:26:18Z [Term] id: CL:0002396 name: CD14-low, CD16-positive monocyte def: "A patrolling monocyte that is CD14-low and CD16-positive." [GOC:tfm, PMID:20870168] comment: Markers are associated with human monocytes. subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "non-classical monocyte, human" EXACT [] is_a: CL:0000875 {is_inferred="true"} ! non-classical monocyte is_a: CL:0001054 ! CD14-positive monocyte intersection_of: CL:0000875 ! non-classical monocyte intersection_of: RO:0002104 PR:000001483 ! has plasma membrane part low affinity immunoglobulin gamma Fc region receptor III intersection_of: RO:0015016 PR:000001889 ! has low plasma membrane amount CD14 molecule relationship: RO:0002104 PR:000001483 ! has plasma membrane part low affinity immunoglobulin gamma Fc region receptor III relationship: RO:0002202 CL:0002397 ! develops from CD14-positive, CD16-positive monocyte relationship: RO:0015016 PR:000001889 ! has low plasma membrane amount CD14 molecule property_value: RO:0002175 NCBITaxon:9606 property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-10-04T12:25:42Z [Term] id: CL:0002397 name: CD14-positive, CD16-positive monocyte def: "A CD14-positive monocyte that is also CD16-positive and CCR2-negative." [GOC:tfm, PMID:20628149, PMID:21937707, PMID:22343568] comment: This cell type is compatible with the HIPC Lyoplate markers for 'CD16+ monocyte'. Markers are associated with human cells. Note that this cell type encompasses both human intermediate monocytes (CD14+, CD16-low), and human non-classical monocytes (CD14-low, CD16+). subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "CD16+ monocyte" EXACT [PMID:22343568] is_a: CL:0001054 ! CD14-positive monocyte intersection_of: CL:0001054 ! CD14-positive monocyte intersection_of: CL:4030046 PR:000001199 ! lacks_plasma_membrane_part C-C chemokine receptor type 2 intersection_of: RO:0002104 PR:000001483 ! has plasma membrane part low affinity immunoglobulin gamma Fc region receptor III relationship: CL:4030046 PR:000001199 ! lacks_plasma_membrane_part C-C chemokine receptor type 2 relationship: RO:0002104 PR:000001483 ! has plasma membrane part low affinity immunoglobulin gamma Fc region receptor III property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-10-04T12:49:47Z [Term] id: CL:0002398 name: Gr1-positive, CD43-positive monocyte def: "An intermediate monocyte that is Gr1-positive, CD43-positive." [GOC:tfm, PMID:20628149, PMID:27098205] subset: mouse_subset is_a: CL:0001022 ! CD115-positive monocyte is_a: CL:0002393 ! intermediate monocyte intersection_of: CL:0000576 ! monocyte intersection_of: RO:0002104 PR:000001012 ! has plasma membrane part integrin alpha-M intersection_of: RO:0002104 PR:000001879 ! has plasma membrane part leukosialin intersection_of: RO:0002104 PR:000002062 ! has plasma membrane part macrophage colony-stimulating factor 1 receptor intersection_of: RO:0002104 PR:000002980 ! has plasma membrane part lymphocyte antigen 6C2 intersection_of: RO:0002162 NCBITaxon:10090 ! in taxon Mus musculus relationship: RO:0002104 PR:000001879 ! has plasma membrane part leukosialin relationship: RO:0002104 PR:000002980 ! has plasma membrane part lymphocyte antigen 6C2 relationship: RO:0002202 CL:0002395 ! develops from Gr1-high classical monocyte property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-10-04T12:49:49Z [Term] id: CL:0002399 name: CD1c-positive myeloid dendritic cell def: "A myeloid dendritic cell that is CD1c-positive." [GOC:dsd, GOC:tfm, PMID:20204387, PMID:20628149] comment: Normally represent 10-20% of peripheral blood mDCs (human). They are also CD281-positive (TLR1), CD282-positive (TLR2), CD283-positive (TLR3), CD284-positive (TLR4), CD285-positive (TLR5), CD286-positive (TLR6), CD288-positive (TLR8), and CD290-positive (TLR10) [PMID:20204387]. Upon TLR stimulation, these cells were potent producers of CXCL8 (IL-8), while producing little TNF-alpha. subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset is_a: CL:0000782 {is_inferred="true"} ! myeloid dendritic cell intersection_of: CL:0000782 ! myeloid dendritic cell intersection_of: RO:0002104 PR:000002027 ! has plasma membrane part T-cell surface glycoprotein CD1c intersection_of: RO:0002215 GO:0032637 ! capable of interleukin-8 production relationship: RO:0002104 PR:000002027 ! has plasma membrane part T-cell surface glycoprotein CD1c relationship: RO:0002215 GO:0032637 ! capable of interleukin-8 production property_value: RO:0002175 NCBITaxon:9606 property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-10-04T02:39:01Z [Term] id: CL:0002400 name: fraction B/C precursor B cell def: "A precursor B cell that is AA4-positive, IgM-negative, CD19-positive, CD43-positive and HSA-positive." [GOC:tfm, http://www.immgen.org/index_content.html, PMID:37442242] subset: mouse_subset is_a: CL:0000817 {is_inferred="true"} ! precursor B cell intersection_of: CL:0000817 ! precursor B cell intersection_of: CL:4030046 GO:0071753 ! lacks_plasma_membrane_part IgM immunoglobulin complex intersection_of: RO:0002104 PR:000001002 ! has plasma membrane part CD19 molecule intersection_of: RO:0002104 PR:000001879 ! has plasma membrane part leukosialin intersection_of: RO:0002104 PR:000001932 ! has plasma membrane part signal transducer CD24 intersection_of: RO:0002104 PR:000002037 ! has plasma membrane part complement component C1q receptor intersection_of: RO:0002162 NCBITaxon:10090 ! in taxon Mus musculus relationship: RO:0002104 PR:000001879 ! has plasma membrane part leukosialin relationship: RO:0002104 PR:000001932 ! has plasma membrane part signal transducer CD24 relationship: RO:0002104 PR:000002037 ! has plasma membrane part complement component C1q receptor relationship: RO:0002162 NCBITaxon:10090 ! in taxon Mus musculus property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-10-05T10:11:38Z [Term] id: CL:0002401 name: mature dendritic epithelial T cell precursor def: "A thymocyte that has a T cell receptor consisting of a gamma chain that has as part a Vgamma3 segment, and a delta chain. This cell type is CD4-negative, CD8-negative and CD24-negative. This cell-type is found in the fetal thymus with highest numbers occurring at E17-E18." [GOC:tfm, http://www.immgen.org/index_content.html] comment: NOTE: currently variable immune gene segments are not represented in the OBO Foundry. Cross-product definitions were not made as a result. Also, there are three different nomenclatures for the variable gamma segments. subset: human_subset subset: mouse_subset synonym: "mature DEC precursor" EXACT [] synonym: "mature DETC precursor" EXACT [] is_a: CL:0002404 ! fetal thymocyte relationship: RO:0002202 CL:0002218 ! develops from immature dendritic epithelial T cell precursor property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-10-07T02:05:46Z [Term] id: CL:0002402 name: Peyer's patch B cell def: "A resting mature B cell within the Peyer's patch that is CD19-positive, B220-positive, IgM-positive, AA4-negative, CD23-positive, CD43-negative, and CD5-negative." [GOC:tfm, http://www.immgen.org/index_content.html] subset: human_subset subset: mouse_subset synonym: "Peyers patch B cell" EXACT [] is_a: CL:0000822 ! B-2 B cell is_a: CL:0009014 ! Peyer's patch lymphocyte intersection_of: CL:0000785 ! mature B cell intersection_of: BFO:0000050 UBERON:0001211 ! part of Peyer's patch intersection_of: CL:4030046 PR:000001839 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD5 intersection_of: CL:4030046 PR:000001879 ! lacks_plasma_membrane_part leukosialin intersection_of: CL:4030046 PR:000002037 ! lacks_plasma_membrane_part complement component C1q receptor intersection_of: RO:0002104 GO:0071753 ! has plasma membrane part IgM immunoglobulin complex intersection_of: RO:0002104 PR:000001014 ! has plasma membrane part receptor-type tyrosine-protein phosphatase C isoform CD45RABC intersection_of: RO:0002104 PR:000001289 ! has plasma membrane part membrane-spanning 4-domains subfamily A member 1 intersection_of: RO:0002104 PR:000001338 ! has plasma membrane part complement receptor type 2 relationship: CL:4030046 PR:000001839 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD5 relationship: CL:4030046 PR:000002037 ! lacks_plasma_membrane_part complement component C1q receptor relationship: RO:0002104 GO:0071753 ! has plasma membrane part IgM immunoglobulin complex relationship: RO:0002104 PR:000001014 ! has plasma membrane part receptor-type tyrosine-protein phosphatase C isoform CD45RABC relationship: RO:0002104 PR:000001338 ! has plasma membrane part complement receptor type 2 property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-10-05T11:18:03Z [Term] id: CL:0002403 name: mature Vgamma2-positive fetal thymocyte def: "A thymocyte that has a T cell receptor consisting of a gamma chain containing Vgamma2 segment, and a delta chain. This cell type is CD4-negative, CD8-negative and CD24-negative. This cell-type is found in the fetal thymus." [GOC:tfm, http://www.immgen.org/index_content.html] comment: NOTE: currently variable immune gene segments are not represented in the OBO Foundry. Cross-product definitions were not made as a result. Also, there are three different nomenclatures for the variable gamma segments. subset: human_subset subset: mouse_subset synonym: "fetal Vgamma2-positive" EXACT [] is_a: CL:0002404 ! fetal thymocyte relationship: RO:0002202 CL:0002378 ! develops from immature Vgamma2-positive fetal thymocyte property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-10-07T02:24:36Z [Term] id: CL:0002404 name: fetal thymocyte def: "A thymocyte found in the fetal thymus." [GOC:tfm] subset: human_subset subset: mouse_subset is_a: CL:0000893 ! thymocyte property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-10-07T02:28:25Z [Term] id: CL:0002405 name: gamma-delta thymocyte def: "A post-natal thymocyte expressing components of the gamma-delta T cell receptor. This cell type is always double-negative (i.e. CD4-negative, CD8-negative)." [GOC:tfm, PMID:20725107] subset: human_subset subset: mouse_subset synonym: "gammadelta thymocyte" EXACT [] synonym: "gd thymocyte" EXACT [] is_a: CL:0000798 ! gamma-delta T cell is_a: CL:0002489 ! double negative thymocyte intersection_of: CL:0000893 ! thymocyte intersection_of: CL:4030046 PR:000001004 ! lacks_plasma_membrane_part CD4 molecule intersection_of: CL:4030046 PR:000025402 ! lacks_plasma_membrane_part T cell receptor co-receptor CD8 intersection_of: RO:0002104 GO:0042106 ! has plasma membrane part gamma-delta T cell receptor complex property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-10-07T02:33:39Z [Term] id: CL:0002406 name: immature Vgamma2-positive thymocyte def: "A double negative post-natal thymocyte that has a T cell receptor consisting of a gamma chain containing a Vgamma2 segment, and a delta chain. This cell type is CD4-negative, CD8-negative and CD24-positive." [GOC:tfm, http://www.immgen.org] comment: NOTE: currently variable immune gene segments are not represented in the OBO Foundry. Cross-product definitions were not made as a result. Also, there are three different nomenclatures for the variable gamma segments. subset: human_subset subset: mouse_subset synonym: "Vgamma2-positive thymocyte" BROAD [] is_a: CL:0002405 ! gamma-delta thymocyte property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-10-07T02:53:44Z [Term] id: CL:0002407 name: mature Vgamma2-positive thymocyte def: "A thymocyte that has a T cell receptor consisting of a gamma chain containing Vgamma2 segment, and a delta chain. This cell type is CD4-negative, CD8-negative and CD24-negative." [GOC:tfm, http://www.immgen.org/index_content.html] comment: NOTE: currently variable immune gene segments are not represented in the OBO Foundry. Cross-product definitions were not made as a result. Also, there are three different nomenclatures for the variable gamma segments. subset: human_subset subset: mouse_subset synonym: "Vgamma2-positive" EXACT [] is_a: CL:0002405 ! gamma-delta thymocyte relationship: RO:0002202 CL:0002406 ! develops from immature Vgamma2-positive thymocyte property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-10-07T02:53:48Z [Term] id: CL:0002408 name: immature Vgamma2-negative thymocyte def: "A double negative post-natal thymocyte that has a T cell receptor consisting of a gamma chain that does not contain a Vgamma2 segment, and a delta chain. This cell type is CD4-negative, CD8-negative and CD24-positive." [GOC:tfm, http://www.immgen.org] comment: NOTE: currently variable immune gene segments are not represented in the OBO Foundry. Cross-product definitions were not made as a result. Also, there are three different nomenclatures for the variable gamma segments. subset: human_subset subset: mouse_subset synonym: "Vgamma2-negative thymocyte" BROAD [] is_a: CL:0002405 ! gamma-delta thymocyte property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-10-07T02:59:05Z [Term] id: CL:0002409 name: mature Vgamma2-negative thymocyte def: "A thymocyte that has a T cell receptor consisting of a gamma chain that does not contain the Vgamma2 segment, and a delta chain. This cell type is CD4-negative, CD8-negative and CD24-negative." [GOC:tfm, http://www.immgen.org/index_content.html] comment: NOTE: currently variable immune gene segments are not represented in the OBO Foundry. Cross-product definitions were not made as a result. Also, there are three different nomenclatures for the variable gamma segments. subset: human_subset subset: mouse_subset synonym: "Vgamma2-negative" EXACT [] is_a: CL:0002405 ! gamma-delta thymocyte relationship: RO:0002202 CL:0002408 ! develops from immature Vgamma2-negative thymocyte property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-10-07T02:59:08Z [Term] id: CL:0002410 name: pancreatic stellate cell def: "A cell that is found in the periacinar space of the exocrine pancreas and in perivascular and periductal regions of the pancreas, and has long cytoplasmic processes that encircle the base of the acinus. Expresses several intermediate filament proteins including vimentin and nestin. Shares many of the characteristics of hepatatic stellate cells, but not stellate cells of the central nervous system. Upon activation, this cell type undergoes morphological and gene expression changes that make the cell suggestive of being a type of myofibroblast." [GOC:mah, GOC:tfm, PMID:17200706] subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "pancreas stellate cell" EXACT [] synonym: "PaSC" EXACT [] xref: MESH:D058954 is_a: CL:0000057 ! fibroblast is_a: CL:0002574 ! stromal cell of pancreas property_value: RO:0002175 NCBITaxon:9606 property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0002410" xsd:string {name="pancreatic stellate cell on CELLxGENE CellGuide"} property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 property_value: terms:description "Pancreatic stellate cells, also known as PSCs, are a specific type of cell comprising 4-7% the pancreas, specifically the exocrine glandular tissue. In their quiescent state, these cells are characterized by a star-like appearance with long cytoplasmic processes, and store vitamin A droplets in their cytoplasm. The primary roles of pancreatic stellate cells are related to the production, degradation, and reorganization of the extracellular matrix in the pancreas. When activated by injury or stress, they transform into myofibroblast-like cells, beginning to proliferate, migrate and produce large amounts of extracellular matrix proteins that can lead to the fibrosis seen in chronic pancreatitis. Pancreatic stellate cells are also responsible for the synthesis of various growth factors, cytokines, and chemokines, each playing a significant role in the complex network of paracrine and autocrine signaling pathways within the pancreatic tissue. \nThese cells have been implicated in the progression of pancreatic cancer. Activated PSCs can stimulate the growth, invasion, and metastasis of pancreatic cancer cells. They also help form a dense, fibrous 'shield' around cancer cells, known as desmoplasia, which can make it more difficult for anticancer drugs to reach their target. Thus, a lot of research is being conducted on how to control or modify the behavior of pancreatic stellate cells to treat chronic pancreatitis and pancreatic cancer.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1007/s00424-017-1968-0", xref="DOI:10.1007/s00535-009-0013-2", xref="DOI:10.1038/labinvest.2012.161", xref="DOI:10.1136/gut.2008.170233", xref="DOI:10.1158/1078-0432.CCR-14-1051"} creation_date: 2010-11-10T09:40:33Z [Term] id: CL:0002411 name: Vgamma1.1-positive, Vdelta6.3-negative thymocyte def: "A gamma-delta receptor that expresses Vgamma1.1 but does not express Vdelta6.3 chains in the T-cell receptor." [GOC:tfm, http://www.immgen.org/index_content.html, PMID:32979762, PMID:35757696] subset: mouse_subset synonym: "Vg1.1-positive, Vd6.3-negative T cell" EXACT [] is_a: CL:0002405 ! gamma-delta thymocyte relationship: RO:0002162 NCBITaxon:10090 ! in taxon Mus musculus property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-10-07T03:07:44Z [Term] id: CL:0002412 name: Vgamma1.1-positive, Vdelta6.3-positive thymocyte def: "A gamma-delta receptor that expresses Vgamma1.1-Vdelta6.3 chains in the T-cell receptor." [GOC:tfm, http://www.immgen.org/index_content.html, PMID:32979762, PMID:35757696] subset: mouse_subset synonym: "Vg1.1+Vd6.3+ T cell" EXACT [] is_a: CL:0002405 ! gamma-delta thymocyte relationship: RO:0002162 NCBITaxon:10090 ! in taxon Mus musculus property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-10-07T03:03:00Z [Term] id: CL:0002413 name: mature Vgamma1.1-positive, Vdelta6.3-negative thymocyte def: "A Vgamma1.1-positive, Vdelta6.3-negative thymocyte that is CD24-negative." [GOC:tfm, http://www.immgen.org] subset: mouse_subset synonym: "mature Vg1.1-positive, Vd6.3-negative T cell" RELATED [] is_a: CL:0002411 ! Vgamma1.1-positive, Vdelta6.3-negative thymocyte property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-10-07T03:10:32Z [Term] id: CL:0002414 name: immature Vgamma1.1-positive, Vdelta6.3-negative thymocyte def: "A Vgamma1.1-positive, Vdelta6.3-negative thymocyte that is CD24-positive." [GOC:tfm, http://www.immgen.org/index_content.html] subset: mouse_subset synonym: "immature Vg1.1-positive, Vd6.3-negative T cell" RELATED [] is_a: CL:0002411 ! Vgamma1.1-positive, Vdelta6.3-negative thymocyte property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-10-07T03:10:35Z [Term] id: CL:0002415 name: immature Vgamma1.1-positive, Vdelta6.3-positive thymocyte def: "A Vgamma1.1-positive, Vdelta6.3-positive thymocyte that is CD24-positive." [GOC:tfm, http://www.immgen.org/index_content.html] subset: mouse_subset synonym: "immature Vg1.1+Vd6.3+ T cell" EXACT [] is_a: CL:0002412 ! Vgamma1.1-positive, Vdelta6.3-positive thymocyte property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-10-07T03:10:39Z [Term] id: CL:0002416 name: mature Vgamma1.1-positive, Vdelta6.3-positive thymocyte def: "A Vgamma1.1-positive, Vdelta6.3-positive thymocyte that is CD24-negative." [GOC:tfm, http://www.immgen.org/index_content.html] subset: mouse_subset synonym: "mature Vg1.1+Vd6.3+ T cell" EXACT [] is_a: CL:0002412 ! Vgamma1.1-positive, Vdelta6.3-positive thymocyte property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-10-07T03:10:41Z [Term] id: CL:0002417 name: primitive erythroid lineage cell def: "An immature or mature cell of the first erythroid lineage to arise during embryonic development." [GOC:tfm] subset: human_subset subset: mouse_subset is_a: CL:0000764 ! erythroid lineage cell property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-10-12T11:22:41Z [Term] id: CL:0002418 name: hemangioblast def: "A pluripotent cell in the yolk sac that can give rise to mesenchymal cells including erythrocytes and endothelial cells." [GOC:tfm, ISBN:0813817986, PMID:11495698] subset: human_subset subset: mouse_subset xref: MESH:D055018 is_a: BFO:0000002 is_a: CL:0000222 ! mesodermal cell relationship: RO:0002202 CL:0002354 ! develops from yolk sac hematopoietic stem cell property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-10-12T12:21:16Z [Term] id: CL:0002419 name: mature T cell def: "A T cell that expresses a T cell receptor complex and has completed T cell selection." [GOC:tfm] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "CD3e-positive T cell" EXACT [] synonym: "CD3epsilon T cell" RELATED [] synonym: "mature T-cell" EXACT [] is_a: CL:0000084 {is_inferred="true"} ! T cell intersection_of: CL:0000084 ! T cell intersection_of: RO:0002104 GO:0042101 ! has plasma membrane part T cell receptor complex intersection_of: RO:0002353 GO:0045058 ! output of T cell selection relationship: RO:0000053 PATO:0001701 ! has characteristic mature relationship: RO:0002104 GO:0042101 ! has plasma membrane part T cell receptor complex relationship: RO:0002353 GO:0045058 ! output of T cell selection property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-10-12T01:56:15Z [Term] id: CL:0002420 name: immature T cell def: "A T cell that has not completed T cell selection." [GOC:tfm] subset: blood_and_immune_upper_slim subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "immature T-cell" EXACT [] xref: BTO:0001372 xref: CALOHA:TS-1042 is_a: CL:0000084 {is_inferred="true"} ! T cell intersection_of: CL:0000084 ! T cell intersection_of: CL:4030044 GO:0045058 ! has_not_completed T cell selection relationship: CL:4030044 GO:0045058 ! has_not_completed T cell selection relationship: RO:0000053 PATO:0001501 ! has characteristic immature property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-10-12T01:56:17Z [Term] id: CL:0002421 name: nucleated reticulocyte def: "A reticulocyte that retains the nucleus and other organelles. Found in birds, fish, amphibians and reptiles." [GOC:tfm, PMID:18182572, PMID:9011180, PMID:9046052] subset: human_subset subset: mouse_subset is_a: CL:0000558 {is_inferred="true"} ! reticulocyte is_a: CL:0002242 ! nucleate cell intersection_of: CL:0000558 ! reticulocyte intersection_of: RO:0000053 PATO:0002505 ! has characteristic nucleated property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-10-15T09:24:05Z [Term] id: CL:0002422 name: enucleated reticulocyte def: "A reticulocyte lacking a nucleus and showing a basophilic reticulum under vital staining due to the presence of ribosomes." [GOC:tfm, ISBN:0-12203-052-4, ISBN:0721601464] subset: cellxgene_subset subset: human_subset subset: mouse_subset xref: CALOHA:TS-0864 xref: FMA:66785 is_a: CL:0000225 ! anucleate cell is_a: CL:0000558 {is_inferred="true"} ! reticulocyte intersection_of: CL:0000558 ! reticulocyte intersection_of: BFO:0000051 GO:0005840 ! has part ribosome intersection_of: RO:0000053 PATO:0001405 ! has characteristic anucleate relationship: BFO:0000051 GO:0005840 ! has part ribosome property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-10-15T09:24:08Z [Term] id: CL:0002423 name: DN2a thymocyte def: "A DN2 thymocyte that is Kit-hi." [GOC:tfm, PMID:20595614] comment: Observed in mice. There is growing evidence that molecular markers characterizing double negative thymocytes are different across species, especially in mouse versus human thymus. If in doubt, please consider using CL:0002489 'double negative thymocyte'. subset: human_subset subset: mouse_subset is_a: CL:0000806 {is_inferred="true"} ! DN2 thymocyte intersection_of: CL:0000806 ! DN2 thymocyte intersection_of: RO:0015015 PR:000002065 ! has high plasma membrane amount mast/stem cell growth factor receptor relationship: RO:0015015 PR:000002065 ! has high plasma membrane amount mast/stem cell growth factor receptor property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-10-21T10:12:05Z [Term] id: CL:0002424 name: DN2b thymocyte def: "A DN2 thymocyte that is Kit-low." [GOC:tfm, PMID:20595614] comment: Observed in mice. There is growing evidence that molecular markers characterizing double negative thymocytes are different across species, especially in mouse versus human thymus. If in doubt, please consider using CL:0002489 'double negative thymocyte'. subset: human_subset subset: mouse_subset is_a: CL:0000806 {is_inferred="true"} ! DN2 thymocyte intersection_of: CL:0000806 ! DN2 thymocyte intersection_of: RO:0015016 PR:000002065 ! has low plasma membrane amount mast/stem cell growth factor receptor relationship: RO:0002202 CL:0002423 ! develops from DN2a thymocyte relationship: RO:0015016 PR:000002065 ! has low plasma membrane amount mast/stem cell growth factor receptor property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-10-21T10:12:08Z [Term] id: CL:0002425 name: early T lineage precursor def: "A pro-T cell that is lin-negative, CD25-negative, CD127-negative, CD44-positive and kit-positive." [GOC:dsd, GOC:tfm, http://www.immgen.org/index_content.html, PMID:16551251] comment: ETPs are reportedly CD1a-negative, CD4-negative, CD7-positive, CD8a-negative, CD8b-negative, CD33-low, CD34-high, CD38-low, CD45RA-positive, and CD45RO-negative. subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "ETP" EXACT [] synonym: "preT.ETP.Th" EXACT [] is_a: CL:0000827 {is_inferred="true"} ! pro-T cell intersection_of: CL:0000827 ! pro-T cell intersection_of: CL:4030046 PR:000001380 ! lacks_plasma_membrane_part interleukin-2 receptor subunit alpha intersection_of: RO:0002104 PR:000001307 ! has plasma membrane part CD44 molecule intersection_of: RO:0002104 PR:000001869 ! has plasma membrane part interleukin-7 receptor subunit alpha intersection_of: RO:0002104 PR:000002065 ! has plasma membrane part mast/stem cell growth factor receptor relationship: CL:4030046 PR:000001380 ! lacks_plasma_membrane_part interleukin-2 receptor subunit alpha relationship: RO:0002104 PR:000001307 ! has plasma membrane part CD44 molecule relationship: RO:0002104 PR:000001869 ! has plasma membrane part interleukin-7 receptor subunit alpha relationship: RO:0002104 PR:000002065 ! has plasma membrane part mast/stem cell growth factor receptor property_value: RO:0002175 NCBITaxon:9606 property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-10-21T01:16:24Z [Term] id: CL:0002426 name: CD11b-positive, CD27-positive natural killer cell, mouse def: "A mature natural killer cell that is CD11b-positive and CD27-positive." [GOC:tfm, http://www.immgen.org/index_content.html] comment: A natural killer cell that is NK1.1-positive, CD11b-positive, and CD27-positive. subset: mouse_subset is_a: CL:0002438 ! NK1.1-positive natural killer cell, mouse intersection_of: CL:0002438 ! NK1.1-positive natural killer cell, mouse intersection_of: RO:0002104 PR:000001012 ! has plasma membrane part integrin alpha-M intersection_of: RO:0002104 PR:000001963 ! has plasma membrane part CD27 molecule intersection_of: RO:0002162 NCBITaxon:10090 ! in taxon Mus musculus relationship: RO:0002104 PR:000001012 ! has plasma membrane part integrin alpha-M relationship: RO:0002104 PR:000001963 ! has plasma membrane part CD27 molecule property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-10-25T03:07:59Z [Term] id: CL:0002427 name: resting double-positive thymocyte def: "A double-positive, alpha-beta thymocyte that is small and not proliferating." [GOC:tfm, http://www.immgen.org/index_content.html] subset: human_subset subset: mouse_subset synonym: "T.DP.sm.Th" EXACT [] is_a: CL:0000809 {is_inferred="true"} ! double-positive, alpha-beta thymocyte intersection_of: CL:0000809 ! double-positive, alpha-beta thymocyte intersection_of: RO:0000053 PATO:0000587 ! has characteristic decreased size relationship: RO:0000053 PATO:0000587 ! has characteristic decreased size property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-10-21T01:59:06Z [Term] id: CL:0002428 name: double-positive blast def: "A double-positive thymocyte that is large (i.e. has a high forward scatter signal in flow cytometry) and is actively proliferating." [GOC:tfm, http://www.immgen.org/index_content.html] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "activated double-positive thymocyte" EXACT [] synonym: "T.DPb.Th" EXACT [] is_a: CL:0000809 {is_inferred="true"} ! double-positive, alpha-beta thymocyte intersection_of: CL:0000809 ! double-positive, alpha-beta thymocyte intersection_of: RO:0000053 PATO:0000586 ! has characteristic increased size intersection_of: RO:0000056 GO:0008283 ! participates in cell population proliferation relationship: RO:0000053 PATO:0000586 ! has characteristic increased size relationship: RO:0000056 GO:0008283 ! participates in cell population proliferation relationship: RO:0002202 CL:0002427 ! develops from resting double-positive thymocyte property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-10-21T01:59:11Z [Term] id: CL:0002429 name: CD69-positive double-positive thymocyte def: "A double-positive thymocyte that is CD69-positive and has begun positive selection." [GOC:tfm, http://www.immgen.org/index_content.html] subset: human_subset subset: mouse_subset synonym: "T.DP69+.Th" EXACT [] is_a: CL:0000809 {is_inferred="true"} ! double-positive, alpha-beta thymocyte intersection_of: CL:0000809 ! double-positive, alpha-beta thymocyte intersection_of: RO:0000056 GO:0043368 ! participates in positive T cell selection intersection_of: RO:0002104 PR:000001343 ! has plasma membrane part CD69 molecule intersection_of: RO:0015016 GO:0042105 ! has low plasma membrane amount alpha-beta T cell receptor complex relationship: RO:0000056 GO:0043368 ! participates in positive T cell selection relationship: RO:0002104 PR:000001343 ! has plasma membrane part CD69 molecule relationship: RO:0002202 CL:0002428 ! develops from double-positive blast relationship: RO:0015016 GO:0042105 ! has low plasma membrane amount alpha-beta T cell receptor complex property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-10-21T02:11:52Z [Term] id: CL:0002430 name: CD4-intermediate, CD8-positive double-positive thymocyte def: "A double-positive thymocyte that is undergoing positive selection, has high expression of the alpha-beta T cell receptor, is CD69-positive, and is in the process of down regulating the CD4 co-receptor." [GOC:tfm, http://www.immgen.org/index_content.html] subset: human_subset subset: mouse_subset synonym: "T.4int8+.Th" EXACT [] synonym: "T_4int8+_Th" EXACT [] is_a: CL:0000809 {is_inferred="true"} ! double-positive, alpha-beta thymocyte intersection_of: CL:0000809 ! double-positive, alpha-beta thymocyte intersection_of: RO:0000056 GO:0043368 ! participates in positive T cell selection intersection_of: RO:0002104 PR:000001343 ! has plasma membrane part CD69 molecule intersection_of: RO:0015015 GO:0042105 ! has high plasma membrane amount alpha-beta T cell receptor complex intersection_of: RO:0015016 PR:000001004 ! has low plasma membrane amount CD4 molecule relationship: RO:0000056 GO:0043368 ! participates in positive T cell selection relationship: RO:0002104 PR:000001343 ! has plasma membrane part CD69 molecule relationship: RO:0002202 CL:0002429 ! develops from CD69-positive double-positive thymocyte relationship: RO:0015015 GO:0042105 ! has high plasma membrane amount alpha-beta T cell receptor complex relationship: RO:0015016 PR:000001004 ! has low plasma membrane amount CD4 molecule property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-10-21T02:29:19Z [Term] id: CL:0002431 name: CD4-positive, CD8-intermediate double-positive thymocyte def: "A double-positive thymocyte that is undergoing positive selection, has high expression of the alpha-beta T cell receptor, is CD69-positive, and is in the process of down regulating the CD8 co-receptor." [GOC:tfm, http://www.immgen.org/index_content.html] subset: human_subset subset: mouse_subset synonym: "T.4+8int.Th" EXACT [] synonym: "T_4+8int_Th" EXACT [] is_a: CL:0000809 {is_inferred="true"} ! double-positive, alpha-beta thymocyte intersection_of: CL:0000809 ! double-positive, alpha-beta thymocyte intersection_of: RO:0000056 GO:0043368 ! participates in positive T cell selection intersection_of: RO:0002104 PR:000001343 ! has plasma membrane part CD69 molecule intersection_of: RO:0015015 GO:0042105 ! has high plasma membrane amount alpha-beta T cell receptor complex intersection_of: RO:0015016 PR:000025402 ! has low plasma membrane amount T cell receptor co-receptor CD8 relationship: RO:0000056 GO:0043368 ! participates in positive T cell selection relationship: RO:0002104 PR:000001343 ! has plasma membrane part CD69 molecule relationship: RO:0002202 CL:0002429 ! develops from CD69-positive double-positive thymocyte relationship: RO:0015015 GO:0042105 ! has high plasma membrane amount alpha-beta T cell receptor complex relationship: RO:0015016 PR:000025402 ! has low plasma membrane amount T cell receptor co-receptor CD8 property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-10-21T02:29:23Z [Term] id: CL:0002432 name: CD24-positive, CD4 single-positive thymocyte def: "A CD4-positive, CD8-negative thymocyte that is CD24-positive and expresses high levels of the alpha-beta T cell receptor." [GOC:tfm, http://www.immgen.org/index_content.html] comment: Described in the immgene database as being CD24-intermediate. subset: human_subset subset: mouse_subset synonym: "CD24-positive, CD4 single-positive semimature thymocyte" EXACT [] synonym: "T.4SP24int.Th" EXACT [] is_a: CL:0000810 {is_inferred="true"} ! CD4-positive, alpha-beta thymocyte intersection_of: CL:0000810 ! CD4-positive, alpha-beta thymocyte intersection_of: RO:0002104 PR:000001932 ! has plasma membrane part signal transducer CD24 intersection_of: RO:0015015 GO:0042105 ! has high plasma membrane amount alpha-beta T cell receptor complex relationship: RO:0002104 PR:000001932 ! has plasma membrane part signal transducer CD24 relationship: RO:0002202 CL:0002433 ! develops from CD69-positive, CD4-positive single-positive thymocyte relationship: RO:0015015 GO:0042105 ! has high plasma membrane amount alpha-beta T cell receptor complex property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-10-21T02:43:52Z [Term] id: CL:0002433 name: CD69-positive, CD4-positive single-positive thymocyte def: "A CD4-positive, CD8-negative thymocyte that expresses high levels of the alpha-beta T cell receptor and is CD69-positive." [GOC:tfm, http://www.immgen.org/index_content.html] subset: human_subset subset: mouse_subset synonym: "intermediate CD4-single-positive" EXACT [] synonym: "T.4SP69+.Th" EXACT [] is_a: CL:0000810 {is_inferred="true"} ! CD4-positive, alpha-beta thymocyte intersection_of: CL:0000810 ! CD4-positive, alpha-beta thymocyte intersection_of: RO:0002104 PR:000001343 ! has plasma membrane part CD69 molecule intersection_of: RO:0015015 GO:0042105 ! has high plasma membrane amount alpha-beta T cell receptor complex relationship: RO:0002104 PR:000001343 ! has plasma membrane part CD69 molecule relationship: RO:0002202 CL:0002431 ! develops from CD4-positive, CD8-intermediate double-positive thymocyte relationship: RO:0015015 GO:0042105 ! has high plasma membrane amount alpha-beta T cell receptor complex property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-10-21T02:46:02Z [Term] id: CL:0002434 name: CD24-positive, CD8 single-positive thymocyte def: "A CD8-positive, CD4-negative thymocyte that is CD24-positive and expresses high levels of the alpha-beta T cell receptor." [GOC:tfm, http://www.immgen.org/index_content.html] comment: Described in the immgene database as being CD24-intermediate. subset: human_subset subset: mouse_subset synonym: "CD24-positive, CD8 single-positive semimature thymocyte" EXACT [] synonym: "T.8SP24int.Th" EXACT [] is_a: CL:0000811 {is_inferred="true"} ! CD8-positive, alpha-beta thymocyte intersection_of: CL:0000811 ! CD8-positive, alpha-beta thymocyte intersection_of: RO:0002104 PR:000001932 ! has plasma membrane part signal transducer CD24 intersection_of: RO:0015015 GO:0042105 ! has high plasma membrane amount alpha-beta T cell receptor complex relationship: RO:0002104 PR:000001932 ! has plasma membrane part signal transducer CD24 relationship: RO:0002202 CL:0002435 ! develops from CD69-positive, CD8-positive single-positive thymocyte relationship: RO:0015015 GO:0042105 ! has high plasma membrane amount alpha-beta T cell receptor complex property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-10-21T02:59:10Z [Term] id: CL:0002435 name: CD69-positive, CD8-positive single-positive thymocyte def: "A CD8-positive, CD4-negative thymocyte that expresses high levels of the alpha-beta T cell receptor and is CD69-positive." [GOC:tfm, http://www.immgen.org/index_content.html, https://orcid.org/0000-0001-5208-3432] subset: human_subset subset: mouse_subset synonym: "intermediate CD8-single-positive" EXACT [] synonym: "T.8SP69+.Th" EXACT [] is_a: CL:0000811 {is_inferred="true"} ! CD8-positive, alpha-beta thymocyte intersection_of: CL:0000811 ! CD8-positive, alpha-beta thymocyte intersection_of: RO:0002104 PR:000001343 ! has plasma membrane part CD69 molecule intersection_of: RO:0015015 GO:0042105 ! has high plasma membrane amount alpha-beta T cell receptor complex relationship: RO:0002104 PR:000001343 ! has plasma membrane part CD69 molecule relationship: RO:0002202 CL:0002430 ! develops from CD4-intermediate, CD8-positive double-positive thymocyte relationship: RO:0015015 GO:0042105 ! has high plasma membrane amount alpha-beta T cell receptor complex property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-10-21T02:59:14Z [Term] id: CL:0002436 name: mature CD4 single-positive thymocyte def: "A mature CD4-positive, CD8-negative alpha-beta T cell found in the thymus that is CD24-low and has high expression of the T cell receptor." [GOC:tfm, http://www.immgen.org/index_content.html] subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "T.4SP24-.Th" RELATED OMO:0003000 [] is_a: CL:0000624 {is_inferred="true"} ! CD4-positive, alpha-beta T cell intersection_of: CL:0000624 ! CD4-positive, alpha-beta T cell intersection_of: RO:0015015 GO:0042105 ! has high plasma membrane amount alpha-beta T cell receptor complex intersection_of: RO:0015016 PR:000001932 ! has low plasma membrane amount signal transducer CD24 relationship: RO:0002202 CL:0002432 ! develops from CD24-positive, CD4 single-positive thymocyte relationship: RO:0015015 GO:0042105 ! has high plasma membrane amount alpha-beta T cell receptor complex relationship: RO:0015016 PR:000001932 ! has low plasma membrane amount signal transducer CD24 property_value: RO:0002175 NCBITaxon:9606 property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-10-21T03:31:19Z [Term] id: CL:0002437 name: mature CD8 single-positive thymocyte def: "A mature CD8-positive, CD4-negative alpha-beta T cell found in the thymus that is CD24-low and has high expression of the T cell receptor." [GOC:tfm, http://www.immgen.org/index_content.html] subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "T.8SP24-.Th" EXACT [] is_a: CL:0000625 {is_inferred="true"} ! CD8-positive, alpha-beta T cell intersection_of: CL:0000625 ! CD8-positive, alpha-beta T cell intersection_of: RO:0015015 GO:0042105 ! has high plasma membrane amount alpha-beta T cell receptor complex intersection_of: RO:0015016 PR:000001932 ! has low plasma membrane amount signal transducer CD24 relationship: RO:0002202 CL:0002434 ! develops from CD24-positive, CD8 single-positive thymocyte relationship: RO:0015015 GO:0042105 ! has high plasma membrane amount alpha-beta T cell receptor complex relationship: RO:0015016 PR:000001932 ! has low plasma membrane amount signal transducer CD24 property_value: RO:0002175 NCBITaxon:9606 property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-10-21T03:51:50Z [Term] id: CL:0002438 name: NK1.1-positive natural killer cell, mouse def: "A mature NK cell that is NK1.1-positive." [GOC:tfm] comment: Note: Nk1.1 expression is restricted to C57BL strains of laboratory mice. subset: mouse_subset synonym: "NK.sp" EXACT [] synonym: "NK1.1-positive NK cell" EXACT [] is_a: CL:0000824 ! mature natural killer cell intersection_of: CL:0000824 ! mature natural killer cell intersection_of: RO:0002104 PR:000002977 ! has plasma membrane part killer cell lectin-like receptor subfamily B member 1C intersection_of: RO:0002162 NCBITaxon:10090 ! in taxon Mus musculus relationship: RO:0002104 PR:000002977 ! has plasma membrane part killer cell lectin-like receptor subfamily B member 1C relationship: RO:0002162 NCBITaxon:10090 ! in taxon Mus musculus property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-10-25T03:18:04Z [Term] id: CL:0002439 name: NKGA2-positive natural killer cell, mouse def: "A NK1.1-positive T cell that is NKGA2-positive." [GOC:tfm, http://www.immgen.org/index_content.html] subset: mouse_subset synonym: "NK.G2A+.SP" EXACT [] is_a: CL:0002438 ! NK1.1-positive natural killer cell, mouse intersection_of: CL:0002438 ! NK1.1-positive natural killer cell, mouse intersection_of: RO:0002104 PR:000002023 ! has plasma membrane part NKG2-A/NKG2-B type II integral membrane protein intersection_of: RO:0002162 NCBITaxon:10090 ! in taxon Mus musculus relationship: RO:0002104 PR:000002023 ! has plasma membrane part NKG2-A/NKG2-B type II integral membrane protein property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-10-25T03:31:09Z [Term] id: CL:0002440 name: Ly49D-positive natural killer cell, mouse def: "A NK1.1-positive T cell that is Ly49D-positive." [GOC:tfm, http://www.immgen.org/index_content.html] subset: mouse_subset synonym: "NK.49D+.Sp" EXACT [] is_a: CL:0002438 ! NK1.1-positive natural killer cell, mouse intersection_of: CL:0002438 ! NK1.1-positive natural killer cell, mouse intersection_of: RO:0002104 PR:000009619 ! has plasma membrane part killer cell lectin-like receptor 4 intersection_of: RO:0002162 NCBITaxon:10090 ! in taxon Mus musculus relationship: RO:0002104 PR:000009619 ! has plasma membrane part killer cell lectin-like receptor 4 property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-10-25T03:36:19Z [Term] id: CL:0002441 name: CD94-positive natural killer cell, mouse def: "A NK1.1-positive T cell that is CD94-positive." [GOC:tfm, http://www.immgen.org/index_content.html] subset: mouse_subset synonym: "NK.94+.Sp" EXACT [] is_a: CL:0002438 ! NK1.1-positive natural killer cell, mouse intersection_of: CL:0002438 ! NK1.1-positive natural killer cell, mouse intersection_of: RO:0002104 PR:000001402 ! has plasma membrane part killer cell lectin-like receptor subfamily D member 1 intersection_of: RO:0002162 NCBITaxon:10090 ! in taxon Mus musculus relationship: RO:0002104 PR:000001402 ! has plasma membrane part killer cell lectin-like receptor subfamily D member 1 property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-10-25T03:36:28Z [Term] id: CL:0002442 name: CD94-negative, Ly49CI-negative natural killer cell, mouse def: "A NK1.1-positive T cell that is CD94-negative and Ly49Cl-negative." [GOC:tfm, http://www.immgen.org/index_content.html] subset: mouse_subset synonym: "CD94- Ly49I-negative NK cell" EXACT [] synonym: "NK.49Cl-94-.Sp" EXACT [] is_a: CL:0000623 ! natural killer cell intersection_of: CL:0000623 ! natural killer cell intersection_of: CL:4030046 PR:000001402 ! lacks_plasma_membrane_part killer cell lectin-like receptor subfamily D member 1 intersection_of: CL:4030046 PR:000009618 ! lacks_plasma_membrane_part killer cell lectin-like receptor 3 intersection_of: RO:0002162 NCBITaxon:10090 ! in taxon Mus musculus relationship: CL:4030046 PR:000001402 ! lacks_plasma_membrane_part killer cell lectin-like receptor subfamily D member 1 relationship: CL:4030046 PR:000009618 ! lacks_plasma_membrane_part killer cell lectin-like receptor 3 relationship: RO:0002162 NCBITaxon:10090 ! in taxon Mus musculus property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-10-25T03:56:21Z [Term] id: CL:0002443 name: Ly49CI-positive natural killer cell, mouse def: "A NK1.1-positive T cell that is Ly49Cl-positive." [GOC:tfm, http://www.immgen.org/index_content.html] subset: mouse_subset synonym: "Ly49I-positive NK cell" EXACT [] synonym: "NK.49Cl+.Sp" EXACT [] is_a: CL:0002438 ! NK1.1-positive natural killer cell, mouse intersection_of: CL:0002438 ! NK1.1-positive natural killer cell, mouse intersection_of: RO:0002104 PR:000009618 ! has plasma membrane part killer cell lectin-like receptor 3 intersection_of: RO:0002162 NCBITaxon:10090 ! in taxon Mus musculus relationship: RO:0002104 PR:000009618 ! has plasma membrane part killer cell lectin-like receptor 3 property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-10-25T03:36:38Z [Term] id: CL:0002444 name: Ly49H-positive natural killer cell, mouse def: "A NK1.1-positive T cell that is Ly49H-positive." [GOC:tfm, http://www.immgen.org/index_content.html] subset: mouse_subset synonym: "LyH49H-positive" EXACT [] is_a: CL:0002438 ! NK1.1-positive natural killer cell, mouse intersection_of: CL:0002438 ! NK1.1-positive natural killer cell, mouse intersection_of: RO:0002104 PR:000009623 ! has plasma membrane part killer cell lectin-like receptor 8 intersection_of: RO:0002162 NCBITaxon:10090 ! in taxon Mus musculus relationship: RO:0002104 PR:000009623 ! has plasma membrane part killer cell lectin-like receptor 8 property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-10-25T03:36:43Z [Term] id: CL:0002445 name: Ly49D-negative natural killer cell, mouse def: "A NK1.1-positive T cell that is Ly49D-negative." [GOC:tfm, http://www.immgen.org/index_content.html] subset: mouse_subset synonym: "NK.49D-.Sp" EXACT [] is_a: CL:0002438 ! NK1.1-positive natural killer cell, mouse intersection_of: CL:0002438 ! NK1.1-positive natural killer cell, mouse intersection_of: CL:4030046 PR:000009619 ! lacks_plasma_membrane_part killer cell lectin-like receptor 4 intersection_of: RO:0002162 NCBITaxon:10090 ! in taxon Mus musculus relationship: CL:4030046 PR:000009619 ! lacks_plasma_membrane_part killer cell lectin-like receptor 4 property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-10-25T03:39:02Z [Term] id: CL:0002446 name: Ly49CI-negative natural killer cell, mouse def: "A NK1.1-positive T cell that is Ly49Cl-negative." [GOC:tfm, http://www.immgen.org/index_content.html] subset: mouse_subset synonym: "Ly49I-negative NK cell" EXACT [] synonym: "NK.49Cl-.Sp" EXACT [] is_a: CL:0002438 ! NK1.1-positive natural killer cell, mouse intersection_of: CL:0002438 ! NK1.1-positive natural killer cell, mouse intersection_of: CL:4030046 PR:000009618 ! lacks_plasma_membrane_part killer cell lectin-like receptor 3 intersection_of: RO:0002162 NCBITaxon:10090 ! in taxon Mus musculus relationship: CL:4030046 PR:000009618 ! lacks_plasma_membrane_part killer cell lectin-like receptor 3 property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-10-25T03:52:04Z [Term] id: CL:0002447 name: CD94-negative natural killer cell, mouse def: "A NK1.1-positive T cell that is CD94-negative." [GOC:tfm, http://www.immgen.org/index_content.html] subset: mouse_subset synonym: "NK.94-.Sp" EXACT [] is_a: CL:0002438 ! NK1.1-positive natural killer cell, mouse intersection_of: CL:0002438 ! NK1.1-positive natural killer cell, mouse intersection_of: CL:4030046 PR:000001402 ! lacks_plasma_membrane_part killer cell lectin-like receptor subfamily D member 1 intersection_of: RO:0002162 NCBITaxon:10090 ! in taxon Mus musculus relationship: CL:4030046 PR:000001402 ! lacks_plasma_membrane_part killer cell lectin-like receptor subfamily D member 1 property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-10-25T03:54:18Z [Term] id: CL:0002448 name: Ly49H-negative natural killer cell, mouse def: "A NK1.1-positive T cell that is Ly49H-negative." [GOC:tfm, http://www.immgen.org/index_content.html] subset: mouse_subset synonym: "LyH49H-negative" EXACT [] is_a: CL:0002438 ! NK1.1-positive natural killer cell, mouse intersection_of: CL:0002438 ! NK1.1-positive natural killer cell, mouse intersection_of: CL:4030046 PR:000009623 ! lacks_plasma_membrane_part killer cell lectin-like receptor 8 intersection_of: RO:0002162 NCBITaxon:10090 ! in taxon Mus musculus relationship: CL:4030046 PR:000009623 ! lacks_plasma_membrane_part killer cell lectin-like receptor 8 property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-10-25T03:42:42Z [Term] id: CL:0002449 name: CD94-positive Ly49CI-positive natural killer cell, mouse def: "A NK1.1-positive T cell that is CD94-positive and Ly49Cl-positive." [GOC:tfm, http://www.immgen.org/index_content.html] subset: mouse_subset synonym: "NK.49Cl+94+.Sp" EXACT [] is_a: CL:0002441 ! CD94-positive natural killer cell, mouse is_a: CL:0002443 ! Ly49CI-positive natural killer cell, mouse intersection_of: CL:0002438 ! NK1.1-positive natural killer cell, mouse intersection_of: RO:0002104 PR:000001402 ! has plasma membrane part killer cell lectin-like receptor subfamily D member 1 intersection_of: RO:0002104 PR:000009618 ! has plasma membrane part killer cell lectin-like receptor 3 intersection_of: RO:0002162 NCBITaxon:10090 ! in taxon Mus musculus property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-10-25T03:56:27Z [Term] id: CL:0002450 name: tether cell def: "A specialized hair cell that has an elongated kinocilium upon which an otolith accretes. The tether cell then anchors the otolith in place." [GOC:cvs, GOC:tfm, PMID:9398434] subset: human_subset subset: mouse_subset xref: ZFA:0005565 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0002374 ! ear hair cell property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-11-10T01:41:00Z [Term] id: CL:0002451 name: mammary stem cell def: "A multi-fate stem cell that is the source of cells for growth of the mammary gland during puberty and gestation. This cell type gives rise to both the luminal and myoepithelial cell types of the gland, and have been shown to have the ability to regenerate the entire organ in mice. This cell type also plays an important role in carcinogenesis of the breast. This cell type is Lin-, CD24-positive, CD29-hi." [GOC:hjd, GOC:tfm, PMID:15987436, PMID:16397499, PMID:17851544] subset: human_subset subset: mouse_subset is_a: CL:0000048 ! multi fate stem cell property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-11-10T01:46:51Z [Term] id: CL:0002453 name: oligodendrocyte precursor cell def: "A proliferative and migratory glial progenitor cell that derives from a neural stem cell and resides within the central nervous system. It possesses the capacity to differentiate into a committed oligodendrocyte progenitor (COP) through a well-defined series of maturation steps, ultimately giving rise to a myelinating oligodendrocyte (MOL). In mice and humans, it is characterized by the expression of specific molecular markers, including Pdgfra, Cspg4 (also known as NG2) and Olig2." [GOC:tfm, PMID:16367798, PMID:20142420, PMID:31583586, PMID:31726662, PMID:37653126] subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "NG2 cell" RELATED [PMID:14501223] synonym: "O2-A" RELATED OMO:0003000 [PMID:2182078] synonym: "OPC" RELATED OMO:0003000 [PMID:14501223] synonym: "Polydendrocyte" RELATED [PMID:23516142] xref: MESH:D000073637 is_a: CL:0000123 ! neuron associated cell (sensu Vertebrata) is_a: CL:0011026 ! progenitor cell relationship: BFO:0000050 CL:0000125 ! part of glial cell relationship: BFO:0000050 UBERON:0001017 ! part of central nervous system relationship: RO:0002202 CL:0000047 ! develops from neural stem cell relationship: RO:0002202 CL:0000339 ! develops from glioblast (sensu Vertebrata) relationship: RO:0002203 CL:4023059 ! develops into committed oligodendrocyte precursor property_value: RO:0002175 NCBITaxon:9606 property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0002453" xsd:string {name="oligodendrocyte precursor cell on CELLxGENE CellGuide"} property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 property_value: terms:description "An oligodendrocyte precursor cell (OPC), also commonly referred to as an oligodendrocyte progenitor cell, is an undifferentiated or immature type of cell found in the nervous system that differentiates into a fully mature oligodendrocyte. Oligodendrocytes are known for their role in creating the protective myelin sheath that covers and insulates neurons in the central nervous system, enhancing the speed and efficiency of neurological signal transmission. OPCs contribute to this vital process by providing a consistent source of new oligodendrocytes.\nOPCs are unique for their remarkable flexibility and adaptability, making them a critical element in many neurological processes. They are involved in neurogenesis and reparative functions as they can proliferate and be mobilized to areas of brain injury to aid in tissue repair and regeneration. Particularly, they play a significant role in the recovery and remyelination of damaged neurons, attributing to their prolific distribution in both gray and white matter areas of the brain and spinal cord.\nRecent research has revealed the broader plasticity of OPCs. Studies have shown that OPCs can also differentiate into astrocytes and neurons under certain conditions, enlarging their role from just players in myelination to contributors in maintaining the integrity and adaptability of the central nervous system. Furthermore, these cells have been found to interact directly with neurons and take part in synaptic transmission, implying a more complex role in neural network activity.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1016/S0166-2236(00)01691-X", xref="DOI:10.1016/j.ceb.2021.05.003", xref="DOI:10.1016/j.neuron.2011.05.013", xref="DOI:10.1101/gad.344218.120", xref="DOI:10.1111/j.1460-9568.2006.04625.x"} property_value: terms:description "This cell type can be purified from optic nerves and other regions of the embryonic, postnatal and adult rat CNS and can be differentiated in vitro to oligodendrocytes and type-2 astrocytes. Some references use the terms 'oligodendrocyte precursor cell' and 'oligodendrocyte type-2 astrocyte (O-2A) progenitor' to refer to the same entity (e.g., PMID:10704434), while others describe an oligodendrocyte type-2 astrocyte (O-2A) progenitor cell as the precurosr to oligodendrocyte- and type-2 astrocyte- progenitor cells (e.g, ISBN:9780702028991)." xsd:string {xref="ISBN:9780702028991", xref="PMID:10704434", xref="PMID:2182078"} creation_date: 2010-11-10T02:51:34Z [Term] id: CL:0002454 name: CD4-negative, CD8-alpha-negative, CD11b-positive dendritic cell def: "CD4-negative, CD8-alpha-negative, CD11b-positive dendritic cell is a conventional dendritic cell that is CD11b-positive, CD4-negative, CD8-alpha-negative and is CD205-positive." [GOC:tfm, http://www.immgen.org/index_content.html] subset: human_subset subset: mouse_subset synonym: "DC.8-4-11b+" EXACT [] synonym: "spleen double-negative dendritic cell" EXACT [] is_a: CL:0002465 {is_inferred="true"} ! CD11b-positive dendritic cell intersection_of: CL:0002465 ! CD11b-positive dendritic cell intersection_of: CL:4030046 PR:000001004 ! lacks_plasma_membrane_part CD4 molecule intersection_of: CL:4030046 PR:000001084 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD8 alpha chain relationship: CL:4030046 PR:000001004 ! lacks_plasma_membrane_part CD4 molecule relationship: CL:4030046 PR:000001084 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD8 alpha chain property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-11-22T01:10:28Z [Term] id: CL:0002455 name: CD8-alpha-negative plasmacytoid dendritic cell def: "A CD11c-low plasmacytoid dendritic cell that is CD8-alpha-negative and CD4-positive." [GOC:tfm, http://www.immgen.org/index_content.html] subset: mouse_subset synonym: "DC.pDC.8-" EXACT [] is_a: CL:0000989 {is_inferred="true"} ! CD11c-low plasmacytoid dendritic cell intersection_of: CL:0000989 ! CD11c-low plasmacytoid dendritic cell intersection_of: CL:4030046 PR:000001084 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD8 alpha chain intersection_of: RO:0002104 PR:000001004 ! has plasma membrane part CD4 molecule relationship: CL:4030046 PR:000001084 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD8 alpha chain relationship: RO:0002104 PR:000001004 ! has plasma membrane part CD4 molecule property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-11-22T01:27:37Z [Term] id: CL:0002456 name: CD8-alpha-positive plasmacytoid dendritic cell def: "A CD11c-low plasmacytoid dendritic cell that is CD8-alpha-positive and CD4-positive." [GOC:tfm, http://www.immgen.org/index_content.html] subset: mouse_subset synonym: "DC.pDC.8+" EXACT [] is_a: CL:0000989 {is_inferred="true"} ! CD11c-low plasmacytoid dendritic cell intersection_of: CL:0000989 ! CD11c-low plasmacytoid dendritic cell intersection_of: RO:0002104 PR:000001004 ! has plasma membrane part CD4 molecule intersection_of: RO:0002104 PR:000001084 ! has plasma membrane part T-cell surface glycoprotein CD8 alpha chain relationship: RO:0002104 PR:000001004 ! has plasma membrane part CD4 molecule relationship: RO:0002104 PR:000001084 ! has plasma membrane part T-cell surface glycoprotein CD8 alpha chain property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-11-22T01:23:07Z [Term] id: CL:0002457 name: epidermal Langerhans cell def: "A Langerhans cell that is in the epidermis and is CD45-positive, MHCII-positive, and CD11b-positive." [GOC:tfm, http://www.immgen.org/index_content.html] subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset is_a: CL:0000453 {is_inferred="true"} ! Langerhans cell is_a: CL:0002465 ! CD11b-positive dendritic cell intersection_of: CL:0000453 ! Langerhans cell intersection_of: RO:0001025 UBERON:0001003 ! located in skin epidermis intersection_of: RO:0002104 GO:0042613 ! has plasma membrane part MHC class II protein complex intersection_of: RO:0002104 PR:000001012 ! has plasma membrane part integrin alpha-M intersection_of: RO:0002104 PR:000001014 ! has plasma membrane part receptor-type tyrosine-protein phosphatase C isoform CD45RABC relationship: RO:0001025 UBERON:0001003 ! located in skin epidermis relationship: RO:0002104 GO:0042613 ! has plasma membrane part MHC class II protein complex relationship: RO:0002104 PR:000001014 ! has plasma membrane part receptor-type tyrosine-protein phosphatase C isoform CD45RABC property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/2d-ftu/skin-epidermal-ridge/v1.2/assets/2d-ftu-skin-epidermal-ridge.png" xsd:string {terms:licence="http://creativecommons.org/licenses/by/4.0/", xref="doi:10.48539/HBM642.BMZS.772"} property_value: RO:0002175 NCBITaxon:9606 property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-11-22T03:57:57Z [Term] id: CL:0002458 name: langerin-positive dermal dendritic cell def: "A dermal dendritic cell that is langerin-positive and CD103-positive." [GOC:tfm, http://www.immgen.org/index_content.html] subset: human_subset subset: mouse_subset is_a: CL:0001006 {is_inferred="true"} ! dermal dendritic cell is_a: CL:0002461 ! CD103-positive dendritic cell intersection_of: CL:0001006 ! dermal dendritic cell intersection_of: RO:0002104 PR:000001010 ! has plasma membrane part integrin alpha-E property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-11-22T04:06:22Z [Term] id: CL:0002459 name: langerin-negative dermal dendritic cell def: "A dermal dendritic cell that is langerin-negative, CD103-negative, and CD11b-positive." [GOC:tfm, http://www.immgen.org/index_content.html] subset: human_subset subset: mouse_subset is_a: CL:0001006 {is_inferred="true"} ! dermal dendritic cell intersection_of: CL:0001006 ! dermal dendritic cell intersection_of: CL:4030046 PR:000001010 ! lacks_plasma_membrane_part integrin alpha-E intersection_of: RO:0002104 PR:000001012 ! has plasma membrane part integrin alpha-M relationship: CL:4030046 PR:000001010 ! lacks_plasma_membrane_part integrin alpha-E property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-11-22T04:09:44Z [Term] id: CL:0002460 name: CD8-alpha-negative thymic conventional dendritic cell def: "A conventional thymic dendritic cell that is CD8-alpha-negative." [GOC:tfm, http://www.immgen.org/index_content.html, PMID:19273629] subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "DC.8-.Th" EXACT [] is_a: CL:0000941 {is_inferred="true"} ! thymic conventional dendritic cell intersection_of: CL:0000941 ! thymic conventional dendritic cell intersection_of: CL:4030046 PR:000001084 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD8 alpha chain relationship: CL:4030046 PR:000001084 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD8 alpha chain property_value: RO:0002175 NCBITaxon:9606 property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-11-23T10:58:53Z [Term] id: CL:0002461 name: CD103-positive dendritic cell def: "A conventional dendritic cell that is CD103-positive. This cell type is usually found in non-lymphoid tissue." [GOC:tfm, http://www.immgen.org/index_content.html] subset: cellxgene_subset subset: human_subset subset: mouse_subset is_a: CL:0000766 ! myeloid leukocyte is_a: CL:0000990 {is_inferred="true"} ! conventional dendritic cell intersection_of: CL:0000990 ! conventional dendritic cell intersection_of: RO:0002104 PR:000001010 ! has plasma membrane part integrin alpha-E relationship: RO:0002104 PR:000001010 ! has plasma membrane part integrin alpha-E relationship: RO:0002202 CL:0002010 ! develops from pre-conventional dendritic cell property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-11-23T01:32:43Z [Term] id: CL:0002462 name: adipose dendritic cell def: "A F4/80-negative dendritic cell located in adipose tissue." [GOC:tfm, http://www.immgen.org/index_content.html] subset: human_subset subset: mouse_subset is_a: CL:0000766 ! myeloid leukocyte is_a: CL:0000990 {is_inferred="true"} ! conventional dendritic cell is_a: CL:0002320 ! connective tissue cell intersection_of: CL:0000990 ! conventional dendritic cell intersection_of: BFO:0000050 UBERON:0001013 ! part of adipose tissue intersection_of: CL:4030046 PR:000001813 ! lacks_plasma_membrane_part adhesion G protein-coupled receptor E1 relationship: BFO:0000050 UBERON:0001013 ! part of adipose tissue relationship: CL:4030046 PR:000001813 ! lacks_plasma_membrane_part adhesion G protein-coupled receptor E1 relationship: RO:0002202 CL:0002010 ! develops from pre-conventional dendritic cell property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-11-23T01:38:21Z [Term] id: CL:0002463 name: SIRPa-positive adipose dendritic cell def: "An adipose dendritic cell that is SIRPa-positive." [GOC:tfm, http://www.immgen.org/index_content.html] subset: human_subset subset: mouse_subset synonym: "DC.SIRPa+.Ad" EXACT [] is_a: CL:0002462 ! adipose dendritic cell intersection_of: CL:0000990 ! conventional dendritic cell intersection_of: RO:0002104 PR:000001968 ! has plasma membrane part tyrosine-protein phosphatase non-receptor type substrate 1 relationship: RO:0002104 PR:000001968 ! has plasma membrane part tyrosine-protein phosphatase non-receptor type substrate 1 property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-11-23T01:40:44Z [Term] id: CL:0002464 name: SIRPa-negative adipose dendritic cell def: "An adipose dendritic cell that is SIRPa-negative." [GOC:tfm, http://www.immgen.org/index_content.html] subset: human_subset subset: mouse_subset synonym: "DC.SIRPa-.Ad" EXACT [] is_a: CL:0002462 ! adipose dendritic cell intersection_of: CL:0000990 ! conventional dendritic cell intersection_of: CL:4030046 PR:000001968 ! lacks_plasma_membrane_part tyrosine-protein phosphatase non-receptor type substrate 1 relationship: CL:4030046 PR:000001968 ! lacks_plasma_membrane_part tyrosine-protein phosphatase non-receptor type substrate 1 property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-11-23T01:40:46Z [Term] id: CL:0002465 name: CD11b-positive dendritic cell def: "A conventional dendritic cell that expresses CD11b (ITGAM)." [GOC:tfm, http://www.immgen.org/index_content.html] subset: human_subset subset: mouse_subset is_a: CL:0000990 {is_inferred="true"} ! conventional dendritic cell intersection_of: CL:0000990 ! conventional dendritic cell intersection_of: RO:0002104 PR:000001012 ! has plasma membrane part integrin alpha-M relationship: RO:0002104 PR:000001012 ! has plasma membrane part integrin alpha-M property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-11-23T01:50:05Z [Term] id: CL:0002466 name: small intestine serosal dendritic cell def: "A CD11b-positive dendritic cell located in the serosal portion of the small intestine epithelium. This cell type is CD45-positive, MHC-II-positive, CD11c-low, CD103-negative." [GOC:tfm, http://www.immgen.org/index_content.html] subset: human_subset subset: mouse_subset synonym: "DC.11cloSer.SI" EXACT [] is_a: CL:0002465 {is_inferred="true"} ! CD11b-positive dendritic cell intersection_of: CL:0002465 ! CD11b-positive dendritic cell intersection_of: BFO:0000050 UBERON:0001206 ! part of serosa of small intestine intersection_of: CL:4030046 PR:000001010 ! lacks_plasma_membrane_part integrin alpha-E intersection_of: RO:0002104 GO:0042613 ! has plasma membrane part MHC class II protein complex intersection_of: RO:0002104 PR:000001006 ! has plasma membrane part receptor-type tyrosine-protein phosphatase C intersection_of: RO:0015016 PR:000001013 ! has low plasma membrane amount integrin alpha-X relationship: BFO:0000050 UBERON:0001206 ! part of serosa of small intestine relationship: CL:4030046 PR:000001010 ! lacks_plasma_membrane_part integrin alpha-E relationship: RO:0002104 GO:0042613 ! has plasma membrane part MHC class II protein complex relationship: RO:0002104 PR:000001006 ! has plasma membrane part receptor-type tyrosine-protein phosphatase C relationship: RO:0015016 PR:000001013 ! has low plasma membrane amount integrin alpha-X property_value: foaf:depiction http://purl.obolibrary.org/obo/cl/images/Small-intestine-cells.png {dc:license="http://creativecommons.org/licenses/by/4.0/", xref="doi:10.1186/s13619-020-00061-5", comment="Figure depicts a cross section of intestinal villi in the small intestine, including the crypts of Lieberkuhn (seen here as ‘crypt’), as well as the layer specific locations of cells that exist within the gastrointestinal tract. Layers depicted here include epithelium (rows of cells bordering villus), submucosa (white space below the epithelium containing networks of neurons and ganglia depicted in pink), muscularis mucosae (blue layer), muscularis propria (referred to here as muscle layer).\n\nISC: Intestinal Stem Cell \nTA: Transit Amplifying Cells"} property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-11-23T02:00:21Z [Term] id: CL:0002467 name: Gr1-high myeloid suppressor cell def: "A myeloid suppressor cell that is Gr1-high and CD11c-negative." [GOC:tfm, http://www.immgen.org/index_content.html] subset: human_subset subset: mouse_subset synonym: "MDS.Gr1hi" EXACT [] is_a: CL:0000889 {is_inferred="true"} ! myeloid suppressor cell intersection_of: CL:0000889 ! myeloid suppressor cell intersection_of: CL:4030046 PR:000001013 ! lacks_plasma_membrane_part integrin alpha-X intersection_of: RO:0015015 PR:000002980 ! has high plasma membrane amount lymphocyte antigen 6C2 relationship: CL:4030046 PR:000001013 ! lacks_plasma_membrane_part integrin alpha-X relationship: RO:0015015 PR:000002980 ! has high plasma membrane amount lymphocyte antigen 6C2 property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-11-23T02:15:12Z [Term] id: CL:0002468 name: Gr1-low myeloid suppressor cell def: "A myeloid suppressor cell that is Gr1-low and CD11c-positive." [GOC:tfm, http://www.immgen.org/index_content.html] subset: human_subset subset: mouse_subset synonym: "MDS.Gr1lo" EXACT [] is_a: CL:0000889 {is_inferred="true"} ! myeloid suppressor cell intersection_of: CL:0000889 ! myeloid suppressor cell intersection_of: RO:0002104 PR:000001013 ! has plasma membrane part integrin alpha-X intersection_of: RO:0015016 PR:000002980 ! has low plasma membrane amount lymphocyte antigen 6C2 relationship: RO:0002104 PR:000001013 ! has plasma membrane part integrin alpha-X relationship: RO:0015016 PR:000002980 ! has low plasma membrane amount lymphocyte antigen 6C2 property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-11-23T02:19:43Z [Term] id: CL:0002469 name: MHC-II-negative classical monocyte def: "Gr1-high monocyte that lacks MHC-II receptor complex." [GOC:tfm, http://www.immgen.org/index_content.html] subset: mouse_subset synonym: "Mo.6C+II-" EXACT [] is_a: CL:0002395 {is_inferred="true"} ! Gr1-high classical monocyte intersection_of: CL:0002395 ! Gr1-high classical monocyte intersection_of: CL:4030046 GO:0042613 ! lacks_plasma_membrane_part MHC class II protein complex relationship: CL:4030046 GO:0042613 ! lacks_plasma_membrane_part MHC class II protein complex property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-11-23T03:27:12Z [Term] id: CL:0002470 name: MHC-II-positive classical monocyte def: "Gr1-high monocyte that has a MHC-II receptor complex." [GOC:tfm, http://www.immgen.org/index_content.html] subset: cellxgene_subset subset: mouse_subset synonym: "Mo.6c+II" EXACT [] is_a: CL:0002395 {is_inferred="true"} ! Gr1-high classical monocyte intersection_of: CL:0002395 ! Gr1-high classical monocyte intersection_of: RO:0002104 GO:0042613 ! has plasma membrane part MHC class II protein complex relationship: RO:0002104 GO:0042613 ! has plasma membrane part MHC class II protein complex property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-11-23T03:30:21Z [Term] id: CL:0002471 name: MHC-II-negative non-classical monocyte def: "Gr1-low non-classical monocyte that lacks expression of a MHC-II complex." [GOC:tfm, http://www.immgen.org/index_content.html] subset: mouse_subset synonym: "Mo.6C-II-" EXACT [] is_a: CL:0002058 {is_inferred="true"} ! Gr1-low non-classical monocyte intersection_of: CL:0002058 ! Gr1-low non-classical monocyte intersection_of: CL:4030046 GO:0042613 ! lacks_plasma_membrane_part MHC class II protein complex relationship: CL:4030046 GO:0042613 ! lacks_plasma_membrane_part MHC class II protein complex property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-11-23T03:38:15Z [Term] id: CL:0002472 name: MHC-II-low non-classical monocyte def: "Gr1-low non-classical monocyte that has low to intermediate expression of the MHC-II complex." [GOC:tfm, http://www.immgen.org/index_content.html] subset: mouse_subset synonym: "Mo.6C-IIint" EXACT [] is_a: CL:0002058 {is_inferred="true"} ! Gr1-low non-classical monocyte intersection_of: CL:0002058 ! Gr1-low non-classical monocyte intersection_of: RO:0015016 GO:0042613 ! has low plasma membrane amount MHC class II protein complex relationship: RO:0015016 GO:0042613 ! has low plasma membrane amount MHC class II protein complex property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-11-23T03:47:53Z [Term] id: CL:0002473 name: MHC-II-high non-classical monocyte def: "Gr1-low non-classical monocyte that has high surface expression of a MHC-II complex." [GOC:tfm, http://www.immgen.org/index_content.html] subset: mouse_subset synonym: "Mo.6C-II+" EXACT [] is_a: CL:0002058 {is_inferred="true"} ! Gr1-low non-classical monocyte intersection_of: CL:0002058 ! Gr1-low non-classical monocyte intersection_of: RO:0015015 GO:0042613 ! has high plasma membrane amount MHC class II protein complex relationship: RO:0015015 GO:0042613 ! has high plasma membrane amount MHC class II protein complex property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-11-23T03:47:55Z [Term] id: CL:0002474 name: lymphoid MHC-II-negative classical monocyte def: "A MHC-II-negative classical monocyte located in lymphoid tissue that is F4/80-positive, CD11c-negative, and CD11b-high." [GOC:tfm, http://www.immgen.org/index_content.html] subset: mouse_subset is_a: CL:0002469 {is_inferred="true"} ! MHC-II-negative classical monocyte intersection_of: CL:0002469 ! MHC-II-negative classical monocyte intersection_of: CL:4030046 PR:000001013 ! lacks_plasma_membrane_part integrin alpha-X intersection_of: RO:0002104 PR:000001813 ! has plasma membrane part adhesion G protein-coupled receptor E1 intersection_of: RO:0015015 PR:000001012 ! has high plasma membrane amount integrin alpha-M relationship: CL:4030046 PR:000001013 ! lacks_plasma_membrane_part integrin alpha-X relationship: RO:0002104 PR:000001813 ! has plasma membrane part adhesion G protein-coupled receptor E1 relationship: RO:0015015 PR:000001012 ! has high plasma membrane amount integrin alpha-M property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-11-23T04:00:52Z [Term] id: CL:0002475 name: lymphoid MHC-II-negative non-classical monocyte def: "A MHC-II-negative classical monocyte located in lymphoid tissue that is F4/80-positive, CD11c-intermediate, and CD11b-high." [GOC:tfm, http://www.immgen.org/index_content.html] subset: mouse_subset is_a: CL:0002471 ! MHC-II-negative non-classical monocyte intersection_of: CL:0002471 ! MHC-II-negative non-classical monocyte intersection_of: RO:0002104 PR:000001013 ! has plasma membrane part integrin alpha-X intersection_of: RO:0002104 PR:000001813 ! has plasma membrane part adhesion G protein-coupled receptor E1 intersection_of: RO:0015015 PR:000001012 ! has high plasma membrane amount integrin alpha-M relationship: RO:0002104 PR:000001013 ! has plasma membrane part integrin alpha-X relationship: RO:0002104 PR:000001813 ! has plasma membrane part adhesion G protein-coupled receptor E1 relationship: RO:0015015 PR:000001012 ! has high plasma membrane amount integrin alpha-M property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-11-23T04:09:09Z [Term] id: CL:0002476 name: bone marrow macrophage def: "A tissue-resident macrophage located in the bone marrow. This cell type is B220-negative, CD3e-negative, Ly-6C-negative, CD115-positive, F4/80-positive." [GOC:tfm, http://www.immgen.org/index_content.html] subset: human_subset subset: mouse_subset synonym: "MF.BM" RELATED OMO:0003000 [] xref: BTO:0004732 is_a: CL:0000864 {is_inferred="true"} ! tissue-resident macrophage is_a: CL:0010004 ! mononuclear cell of bone marrow intersection_of: CL:0000864 ! tissue-resident macrophage intersection_of: CL:4030046 PR:000001014 ! lacks_plasma_membrane_part receptor-type tyrosine-protein phosphatase C isoform CD45RABC intersection_of: CL:4030046 PR:000001020 ! lacks_plasma_membrane_part CD3 epsilon intersection_of: CL:4030046 PR:000002980 ! lacks_plasma_membrane_part lymphocyte antigen 6C2 intersection_of: RO:0002104 PR:000001813 ! has plasma membrane part adhesion G protein-coupled receptor E1 intersection_of: RO:0002104 PR:000002062 ! has plasma membrane part macrophage colony-stimulating factor 1 receptor relationship: CL:4030046 PR:000001014 ! lacks_plasma_membrane_part receptor-type tyrosine-protein phosphatase C isoform CD45RABC relationship: CL:4030046 PR:000001020 ! lacks_plasma_membrane_part CD3 epsilon relationship: CL:4030046 PR:000002980 ! lacks_plasma_membrane_part lymphocyte antigen 6C2 relationship: RO:0002104 PR:000001813 ! has plasma membrane part adhesion G protein-coupled receptor E1 relationship: RO:0002104 PR:000002062 ! has plasma membrane part macrophage colony-stimulating factor 1 receptor property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-11-23T04:19:25Z [Term] id: CL:0002477 name: adipose macrophage def: "A macrophage located in adipose tissue that is CD45-positive, CD11c-positive, and SIRPa-positive." [GOC:tfm] subset: cellxgene_subset subset: human_subset subset: mouse_subset is_a: CL:0000864 {is_inferred="true"} ! tissue-resident macrophage intersection_of: CL:0000864 ! tissue-resident macrophage intersection_of: RO:0002104 PR:000001006 ! has plasma membrane part receptor-type tyrosine-protein phosphatase C intersection_of: RO:0002104 PR:000001013 ! has plasma membrane part integrin alpha-X intersection_of: RO:0002104 PR:000001968 ! has plasma membrane part tyrosine-protein phosphatase non-receptor type substrate 1 relationship: RO:0002104 PR:000001006 ! has plasma membrane part receptor-type tyrosine-protein phosphatase C relationship: RO:0002104 PR:000001013 ! has plasma membrane part integrin alpha-X relationship: RO:0002104 PR:000001968 ! has plasma membrane part tyrosine-protein phosphatase non-receptor type substrate 1 property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-11-23T04:31:28Z [Term] id: CL:0002478 name: F4/80-negative adipose macrophage def: "An adipose macrophage that does not express F4/80but is MHC-II-positive. This cell type exhibits autofluorescence under typical flow cyometry conditions." [GOC:tfm, http://www.immgen.org/index_content.html] subset: human_subset subset: mouse_subset synonym: "MF.Autofl.Ad" EXACT [] is_a: CL:0002477 {is_inferred="true"} ! adipose macrophage intersection_of: CL:0002477 ! adipose macrophage intersection_of: CL:4030046 PR:000001813 ! lacks_plasma_membrane_part adhesion G protein-coupled receptor E1 intersection_of: RO:0002104 GO:0042613 ! has plasma membrane part MHC class II protein complex relationship: CL:4030046 PR:000001813 ! lacks_plasma_membrane_part adhesion G protein-coupled receptor E1 relationship: RO:0002104 GO:0042613 ! has plasma membrane part MHC class II protein complex property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-11-23T04:40:50Z [Term] id: CL:0002479 name: F4/80-positive adipose macrophage def: "An adipose macrophage that does not express MHC-II but is F4/80-positive." [GOC:tfm, http://www.immgen.org/index_content.html] subset: human_subset subset: mouse_subset synonym: "MF.F480+.Ad" EXACT [] is_a: CL:0002477 {is_inferred="true"} ! adipose macrophage intersection_of: CL:0002477 ! adipose macrophage intersection_of: CL:4030046 GO:0042613 ! lacks_plasma_membrane_part MHC class II protein complex intersection_of: RO:0002104 PR:000001813 ! has plasma membrane part adhesion G protein-coupled receptor E1 relationship: CL:4030046 GO:0042613 ! lacks_plasma_membrane_part MHC class II protein complex relationship: RO:0002104 PR:000001813 ! has plasma membrane part adhesion G protein-coupled receptor E1 property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-11-23T04:35:53Z [Term] id: CL:0002480 name: nasal mucosa goblet cell def: "A goblet cell located in the nasal epithelium." [GOC:cjm, GOC:tfm] comment: The marker set LYPD2, MUC5AC can identify the Human cell type nasal mucosa goblet cell in the lung with a confidence of 0.81 (NS-Forest FBeta value). {xref="https://doi.org/10.5281/zenodo.11165918"} subset: cellxgene_subset subset: human_subset subset: mouse_subset xref: MP:0002262 is_a: CL:0002370 ! respiratory tract goblet cell is_a: CL:0002631 ! epithelial cell of upper respiratory tract intersection_of: CL:0000160 ! goblet cell intersection_of: BFO:0000050 UBERON:0001826 ! part of nasal cavity mucosa relationship: BFO:0000050 UBERON:0005384 ! part of nasal cavity epithelium relationship: RO:0015004 CLM:1000027 ! has characterizing marker set NS forest marker set of nasal mucosa goblet cell (Human lung). property_value: RO:0002175 NCBITaxon:9606 property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-12-03T03:03:02Z [Term] id: CL:0002481 name: peritubular myoid cell def: "The flattened smooth myoepithelial cells of mesodermal origin that lie just outside the basal lamina of the seminiferous tubule." [GOC:cjm, GOC:tfm, MP:0006420] subset: cellxgene_subset subset: human_subset subset: mouse_subset is_a: CL:0000185 {is_inferred="true"} ! myoepithelial cell is_a: CL:0002625 ! seminiferous tubule epithelial cell intersection_of: CL:0000185 ! myoepithelial cell intersection_of: BFO:0000050 UBERON:0001343 ! part of seminiferous tubule of testis property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-12-03T03:11:48Z [Term] id: CL:0002482 name: dermal melanocyte def: "A melanocyte that produces pigment in the dermis." [GOC:cjm, GOC:tfm, MP:0009386] subset: human_subset subset: mouse_subset is_a: CL:1000458 ! melanocyte of skin intersection_of: CL:0000148 ! melanocyte intersection_of: BFO:0000050 UBERON:0002067 ! part of dermis relationship: BFO:0000050 UBERON:0002067 ! part of dermis property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-12-03T03:17:05Z [Term] id: CL:0002483 name: hair follicle melanocyte def: "A melanocyte that produces pigment within the hair follicle." [GOC:tfm, MP:0004381] subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset is_a: CL:0002559 ! hair follicle cell is_a: CL:2000000 ! epidermal melanocyte intersection_of: CL:0000148 ! melanocyte intersection_of: BFO:0000050 UBERON:0002073 ! part of hair follicle property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/2d-ftu/skin-hair-follicle/v1.0/assets/2d-ftu-skin-hair-follicle.png" xsd:string {terms:licence="http://creativecommons.org/licenses/by/4.0/", xref="doi:10.48539/HBM853.HLFH.534"} property_value: RO:0002175 NCBITaxon:9606 property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-12-03T03:17:09Z [Term] id: CL:0002484 name: epithelial melanocyte def: "A melanocyte that produces pigment in the epithelium." [GOC:tfm, MP:0009388] comment: The text defintion reference to the MP term appears to reference an epidermal melanocyte term. This term represents any melanocyte in any epithelium. subset: human_subset subset: mouse_subset is_a: CL:0000148 {is_inferred="true"} ! melanocyte intersection_of: CL:0000148 ! melanocyte intersection_of: BFO:0000050 UBERON:0000483 ! part of epithelium relationship: BFO:0000050 UBERON:0000483 ! part of epithelium property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-12-03T03:17:14Z [Term] id: CL:0002485 name: retinal melanocyte def: "A melanocyte of the retina. This cell type is distinct from pigmented retinal epithelium." [GOC:tfm, MP:0010190] subset: eye_upper_slim subset: human_subset subset: mouse_subset is_a: CL:0000148 ! melanocyte is_a: CL:0009004 ! retinal cell intersection_of: CL:0000148 ! melanocyte intersection_of: BFO:0000050 UBERON:0000966 ! part of retina relationship: BFO:0000050 UBERON:0000966 ! part of retina property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-12-03T03:25:32Z [Term] id: CL:0002486 name: strial intermediate cell def: "A melanocyte located between the epithelial marginal cell layer and the mesodermal basal cell layer within the intrastrial space; the predominant cellular component of the electrogenic machinery that generates an endocochlear potential (80-100 mV) ." [GOC:tfm, MP:0000048] subset: human_subset subset: mouse_subset is_a: CL:0000710 ! neurecto-epithelial cell is_a: CL:0002484 ! epithelial melanocyte is_a: CL:0002491 ! auditory epithelial cell intersection_of: CL:0000148 ! melanocyte intersection_of: BFO:0000050 UBERON:0002282 ! part of stria vascularis of cochlear duct relationship: BFO:0000050 UBERON:0002282 ! part of stria vascularis of cochlear duct property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-12-03T03:29:15Z [Term] id: CL:0002487 name: cutaneous/subcutaneous mechanoreceptor cell def: "A neuronal receptor that respond to mechanical pressure or distortion in the skin." [GOC:tfm, MP:0000973] subset: human_subset subset: mouse_subset is_a: CL:0000199 ! mechanoreceptor cell property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-12-06T02:53:30Z [Term] id: CL:0002488 name: trophoblast giant cell def: "A trophoblast cell that has a large volume of cytoplasm, is polyploid and is usually mononuclear but is also occasionally multi-nucleate. This cell type is important in establishing maternal physiology and remodeling of the vasculature of the placenta." [GOC:tfm, MP:0001714, MP:19876834] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "giant trophoblast cell" EXACT [] is_a: CL:0000351 {is_inferred="true"} ! trophoblast cell intersection_of: CL:0000351 ! trophoblast cell intersection_of: RO:0000053 PATO:0000586 ! has characteristic increased size intersection_of: RO:0002215 GO:0001974 ! capable of blood vessel remodeling relationship: RO:0000053 PATO:0000586 ! has characteristic increased size relationship: RO:0002215 GO:0001974 ! capable of blood vessel remodeling property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0002488" xsd:string {name="trophoblast giant cell on CELLxGENE CellGuide"} property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 property_value: terms:description "Trophoblast giant cells are specialized cells that form during the early stages of mammalian embryonic development. Within the trophoblast cell category, these cells, marked by their large, multinucleated structure, play a pivotal role in the early stages of pregnancy, particularly during embryo implantation and the maintenance of pregnancy.\nTrophoblast giant cells are predominantly located at the fetal-maternal interface, where they aid in establishing the connection between the maternal blood supply and the embryonic circulatory system. This is achieved by the invasion and remodeling of maternal spiral arteries, a process carried out by a subset of these cells known as invasive trophoblast giant cells - a necessary step to ensure sufficient nutrient supply to the growing fetus. Additionally, these cells participate in the immune defense mechanism, secreting immunosuppressive molecules to protect against maternal immune rejection.\nThese cells are also the primary sources of progesterone, crucial for maintaining the uterine lining during pregnancy, and placental lactogen, which influences the mother's metabolic state to promote fetal growth. In essence, trophoblast giant cells serve as integral mediators, connecting the developmental needs of the fetus with the adaptive physiological changes in the mother.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1002/dvdy.10291", xref="DOI:10.1007/s00018-019-03104-6", xref="DOI:10.1172/JCI22991", xref="DOI:10.3389/fimmu.2021.717884"} creation_date: 2010-12-06T02:55:24Z [Term] id: CL:0002489 name: double negative thymocyte def: "A thymocyte that lacks expression of CD4 and CD8." [GOC:tfm, MP:0002407] comment: These are precursors to mature T cells; normally, they do not circulate, but are found in the thymus and they have not undergone rearrangement of the alpha and beta T cell receptor genes. subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "CD4-CD8- T cell" EXACT [MP:0002407] synonym: "double negative T cell" EXACT [] is_a: CL:0000893 ! thymocyte intersection_of: CL:0000893 ! thymocyte intersection_of: CL:4030046 PR:000001004 ! lacks_plasma_membrane_part CD4 molecule intersection_of: CL:4030046 PR:000025402 ! lacks_plasma_membrane_part T cell receptor co-receptor CD8 relationship: CL:4030046 PR:000001004 ! lacks_plasma_membrane_part CD4 molecule relationship: CL:4030046 PR:000025402 ! lacks_plasma_membrane_part T cell receptor co-receptor CD8 property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-12-06T03:03:38Z [Term] id: CL:0002490 name: organ of Corti supporting cell def: "A supporting cell of the organ of Corti." [GOC:tfm, MP:0004300] subset: human_subset subset: mouse_subset is_a: CL:0002315 ! supporting cell of cochlea intersection_of: CL:0005014 ! auditory epithelial supporting cell intersection_of: BFO:0000050 UBERON:0002227 ! part of spiral organ of cochlea relationship: BFO:0000050 UBERON:0002227 ! part of spiral organ of cochlea property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-12-06T03:09:01Z [Term] id: CL:0002491 name: auditory epithelial cell def: "A specialized cell involved in auditory sensory perception." [GOC:tfm] subset: cellxgene_subset subset: human_subset subset: mouse_subset is_a: CL:0000098 ! sensory epithelial cell intersection_of: CL:0000066 ! epithelial cell intersection_of: RO:0002215 GO:0050910 ! capable of detection of mechanical stimulus involved in sensory perception of sound relationship: RO:0002215 GO:0050910 ! capable of detection of mechanical stimulus involved in sensory perception of sound property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-12-06T03:18:43Z [Term] id: CL:0002492 name: strial marginal cell def: "A polarized columnar cell that covesr the lateral surface of the cochlear duct, secretes potassium ions and forms a continuous sheet in contact with the endolymph; marginal cells form extensive interdigitations with the basal and intermediate cells in the normal adult stria." [GOC:tfm, MP:0004366] subset: human_subset subset: mouse_subset is_a: CL:0002491 ! auditory epithelial cell property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-12-06T03:20:41Z [Term] id: CL:0002493 name: strial basal cell def: "A polarized cell that is juxtaposed to fibrocytes in the underlying spiral ligament. This cell type secretes potassium ions derived from fibrocytes through gap junctions." [GOC:tfm, MP:0004365] comment: Basal cells form a multi-layered epithelial barrier that separates the extracellular spaces of the stria vascularis and the spiral ligament[PMID:18353863] subset: human_subset subset: mouse_subset is_a: CL:0002491 ! auditory epithelial cell relationship: BFO:0000050 UBERON:0002282 ! part of stria vascularis of cochlear duct property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-12-06T03:26:53Z [Term] id: CL:0002494 name: cardiocyte def: "A cell located in the heart, including both muscle and non muscle cells." [GOC:tfm] comment: From Onard of the FMA: Cardiac muscle cell or cardiac myocyte is a striated muscle cell. Cardiocyte on the other hand is any cell in the heart which includes cells other than muscle cells (e.g. endothelial cell of endocardium). Unless there is a consensus among anatomists that cardiocytes refer only to muscle cells, we will treat them as a general class of cells in the heart. subset: human_subset subset: mouse_subset synonym: "heart cell" EXACT [] xref: BTO:0001539 xref: CALOHA:TS-0115 xref: FMA:83808 xref: FMA:84791 is_a: CL:0000255 ! eukaryotic cell intersection_of: CL:0000000 ! cell intersection_of: BFO:0000050 UBERON:0007100 ! part of primary circulatory organ relationship: BFO:0000050 UBERON:0007100 ! part of primary circulatory organ property_value: skos:prefLabel "cardiocyte" xsd:string property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-12-07T09:37:22Z [Term] id: CL:0002495 name: fetal cardiomyocyte def: "A fetal and neonatal heart cell that undergoes proliferation and is not yet terminally differentiated into a binucleate or a multinucleate cardiac myocyte." [GOC:tfm, MP:0008788] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "embryonic cardiomyocyte" EXACT [] synonym: "neonatal cardiomyocyte" EXACT [] is_a: CL:0000746 ! cardiac muscle cell property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-12-07T09:50:41Z [Term] id: CL:0002496 name: intraepithelial lymphocyte def: "A T cell that is located in the intestinal epithelium and is capable of a mucosal immune response." [GOC:tfm, MP:0008894] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "IEL" EXACT [] synonym: "intraepithelial T cell" EXACT [] synonym: "intraepithelial T-cell" EXACT [] xref: MESH:D000075942 is_a: CL:0002419 {is_inferred="true"} ! mature T cell intersection_of: CL:0002419 ! mature T cell intersection_of: RO:0001025 UBERON:0001277 ! located in intestinal epithelium intersection_of: RO:0002215 GO:0002385 ! capable of mucosal immune response relationship: RO:0001025 UBERON:0001277 ! located in intestinal epithelium relationship: RO:0002215 GO:0002385 ! capable of mucosal immune response property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0002496" xsd:string {name="intraepithelial lymphocyte on CELLxGENE CellGuide"} property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 property_value: terms:description "Intraepithelial lymphocytes (IELs) are a large and diverse population of mainly T cells that reside within the epithelial cell layer of various mucosal tissues in the body, including the skin, intestine, and respiratory tract. These cells represent a substantial amount of the total lymphocyte pool and are most numerous in the intestine. They have distinct phenotypes and functional characteristics compared to lymphocytes residing in other tissues. \nMost intraepithelial lymphocytes express heterodimeric T-cell receptors (TCRs) consisting of αlpha and beta chains (TCRαβ), or less commonly gamma and delta chains (TCRγδ), together with the CD8 co-receptor (αβ or αα); there are also smaller subpopulations of IELs that areCD4+, or negative for both CD4 and CD8. Intraepithelial T cells typically express high levels of activation markers, tissue-homing integrins, and receptors and molecules characteristic of natural killer cells and cytotoxic T lymphocytes. TCRαβ+CD8+ IEL are able to recognize both transformed self antigens via natural killer receptors and foreign antigen via the TCR.\nThe primary function of IELs is to maintain the integrity of mucosal barriers against pathogens. Given their strategic location within the epithelial layer, they are often the first immune cells that encounter invading infectious agents, such as bacteria, fungi, or viruses. Upon encountering pathogens, IELs activate and quickly respond by either directly killing the infected epithelial cells or alerting other immune cells. This rapid response, initiated by IELs, helps constrain the infection at the point of entry and is vital to maintaining the integrity of mucosal barriers. \nIn addition to their central role in maintaining the integrity of epithelial barriers, IELs also play a crucial role in maintaining the physiological health of the epithelia by promoting repair and regeneration after injury. Furthermore, IELs are pivotal in supporting oral tolerance to dietary antigens and gut microbiota. An imbalance in the number and functionality of IELs is often associated with various human diseases including celiac disease, inflammatory bowel disease, metabolic syndrome, and colorectal cancer.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1016/j.it.2017.11.003", xref="DOI:10.1038/nri3007", xref="DOI:10.1038/s41385-018-0016-5", xref="DOI:10.1038/s41385-020-0294-6", xref="https://www.sciencedirect.com/topics/immunology-and-microbiology/intraepithelial-lymphocyte"} creation_date: 2010-12-07T09:54:50Z [Term] id: CL:0002497 name: primary trophoblast giant cell def: "A trophoblast giant cell derived from the mural trophectoderm." [GOC:tfm, PMCID:PMC85124] subset: human_subset subset: mouse_subset xref: EMAPA:16066 is_a: CL:0002488 ! trophoblast giant cell property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-12-07T10:07:47Z [Term] id: CL:0002498 name: secondary trophoblast giant cell def: "A trophoblast giant cell that is derived from ectoplacental cone and, later in gestation, the spongiotrophoblast." [GOC:tfm, PMCID:PMC85124] subset: human_subset subset: mouse_subset is_a: CL:0002488 ! trophoblast giant cell property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-12-07T10:07:52Z [Term] id: CL:0002499 name: spongiotrophoblast cell def: "A trophoblast cell that arises in the junctional zone (basal plate) of the placenta." [GOC:tfm, MP:0008959] subset: human_subset subset: mouse_subset synonym: "spongiotrophoblast" EXACT [] is_a: CL:0000351 ! trophoblast cell relationship: BFO:0000050 UBERON:0004021 ! part of spongiotrophoblast layer property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-12-07T12:56:56Z [Term] id: CL:0002500 name: P enteroendocrine cell def: "A P/D1 enteroendocrine cell that is Grimelius positive and stores bombesin-like polypeptide." [FMA:63418, GOC:tfm] subset: human_subset subset: mouse_subset is_a: CL:0002268 ! P/D1 enteroendocrine cell property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-12-07T03:42:06Z [Term] id: CL:0002501 name: type D1 enteroendocrine cell def: "A P/D1 enteroendocrine cell that is argyrophilic and stores vasoactive intestinal polypeptide." [FMA:63207, GOC:tfm] subset: human_subset subset: mouse_subset xref: FMA:63207 is_a: CL:0002268 ! P/D1 enteroendocrine cell property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-12-07T03:42:09Z [Term] id: CL:0002502 name: type M enteroendocrine cell def: "An enteroendocrine cell of the small intestine that secretes motilin." [GOC:tfm, PMID:15153415] subset: human_subset subset: mouse_subset synonym: "Mo enteroendocrine cell" BROAD [] xref: FMA:63420 is_a: CL:0002272 ! motilin secreting cell is_a: CL:0009006 ! enteroendocrine cell of small intestine property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-12-07T03:55:49Z [Term] id: CL:0002503 name: adventitial cell def: "A cell of the adventitial layer of ductal structures such as the uterer, defent duct, biliary duct, etc" [GOC:tfm] subset: cellxgene_subset subset: human_subset subset: mouse_subset xref: BTO:0002441 xref: FMA:84639 is_a: CL:0000630 ! supporting cell is_a: CL:0002320 ! connective tissue cell intersection_of: CL:0002320 ! connective tissue cell intersection_of: BFO:0000050 UBERON:0005742 ! part of adventitia relationship: BFO:0000050 UBERON:0005742 ! part of adventitia property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-12-07T04:03:56Z [Term] id: CL:0002504 name: enteric smooth muscle cell def: "A smooth muscle cell of the intestine." [GOC:tfm] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "intestinal smooth muscle cell" EXACT [] is_a: CL:0000192 {is_inferred="true"} ! smooth muscle cell intersection_of: CL:0000192 ! smooth muscle cell intersection_of: BFO:0000050 UBERON:0000160 ! part of intestine relationship: BFO:0000050 UBERON:0000160 ! part of intestine property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0002504" xsd:string {name="enteric smooth muscle cell on CELLxGENE CellGuide"} property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 property_value: terms:description "Enteric smooth muscle cells are a specialized type of cell found in the gastrointestinal tract. They are an integral part of the enteric nervous system, which regulates the functions of the gastrointestinal system. These cells have a unique structural organization that enables their primary function: the contraction and relaxation necessary for the propulsion of gastrointestinal contents.\nSmooth muscle cells in the enteric system possess unique attributes that distinguish them from other smooth muscle cells in the body. One crucial function is peristalsis, where these cells contract in a coordinated manner, generating a wave of contraction and relaxation. This peristaltic movement facilitates the movement of food particles through the digestive tract, playing a vital role in the digestion and absorption processes in animals. Additionally, these cells are responsible for maintaining the tone of gastrointestinal sphincters, controlling passage and preventing one-sided movement of the contents.\nEnteric smooth muscle cells are also involved in local immune responses of the gastrointestinal tract. They can communicate with local immune cells and secrete cytokines or other signaling molecules in response to infectious organisms, which makes them crucial mediocellular players in gastrointestinal homeostasis and response to disease. Their interactions with other cell types, such as neurons, myofibroblasts, and interstitial cells of Cajal, further contribute to these cells' role in maintaining the physiological functions of the gastrointestinal system. Overall, enteric smooth muscle cells provide an indispensable contribution to the complex operations of the digestive tract.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1038/nrgastro.2012.168", xref="DOI:10.1111/j.1365-2982.2012.01986.x", xref="DOI:10.1371/journal.pcbi.1009644"} creation_date: 2011-01-17T03:39:38Z [Term] id: CL:0002505 name: liver CD103-negative dendritic cell def: "A CD11b-positive dendritic cell that is CD11b-high, CD45-positive, MHC-II-positive and CD103-negative." [GOC:tfm, http://www.immgen.org/index_content.html] subset: human_subset subset: mouse_subset synonym: "DC.103-11b+.Lv" EXACT [] is_a: CL:0002454 {is_inferred="true"} ! CD4-negative, CD8-alpha-negative, CD11b-positive dendritic cell intersection_of: CL:0002454 ! CD4-negative, CD8-alpha-negative, CD11b-positive dendritic cell intersection_of: CL:4030046 PR:000001010 ! lacks_plasma_membrane_part integrin alpha-E intersection_of: RO:0001025 UBERON:0001281 ! located in hepatic sinusoid intersection_of: RO:0002104 GO:0042613 ! has plasma membrane part MHC class II protein complex intersection_of: RO:0002104 PR:000001006 ! has plasma membrane part receptor-type tyrosine-protein phosphatase C intersection_of: RO:0015015 PR:000001012 ! has high plasma membrane amount integrin alpha-M relationship: CL:4030046 PR:000001010 ! lacks_plasma_membrane_part integrin alpha-E relationship: RO:0001025 UBERON:0001281 ! located in hepatic sinusoid relationship: RO:0002104 GO:0042613 ! has plasma membrane part MHC class II protein complex relationship: RO:0002104 PR:000001006 ! has plasma membrane part receptor-type tyrosine-protein phosphatase C relationship: RO:0015015 PR:000001012 ! has high plasma membrane amount integrin alpha-M property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2011-01-21T01:27:41Z [Term] id: CL:0002506 name: liver CD103-positive dendritic cell def: "A CD11b-positive dendritic cell that is CD11b-low, CD45-positive, MHC-II-high and CD103-positive that is located in the liver." [GOC:tfm, http://www.immgen.org/index_content.html] subset: human_subset subset: mouse_subset synonym: "DC.103+11b-.Lv" EXACT [] is_a: CL:0002454 {is_inferred="true"} ! CD4-negative, CD8-alpha-negative, CD11b-positive dendritic cell is_a: CL:0002461 ! CD103-positive dendritic cell intersection_of: CL:0002454 ! CD4-negative, CD8-alpha-negative, CD11b-positive dendritic cell intersection_of: RO:0001025 UBERON:0001281 ! located in hepatic sinusoid intersection_of: RO:0002104 GO:0042613 ! has plasma membrane part MHC class II protein complex intersection_of: RO:0002104 PR:000001006 ! has plasma membrane part receptor-type tyrosine-protein phosphatase C intersection_of: RO:0002104 PR:000001010 ! has plasma membrane part integrin alpha-E intersection_of: RO:0015016 PR:000001012 ! has low plasma membrane amount integrin alpha-M relationship: RO:0001025 UBERON:0001281 ! located in hepatic sinusoid relationship: RO:0002104 GO:0042613 ! has plasma membrane part MHC class II protein complex relationship: RO:0002104 PR:000001006 ! has plasma membrane part receptor-type tyrosine-protein phosphatase C relationship: RO:0015016 PR:000001012 ! has low plasma membrane amount integrin alpha-M property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2011-01-21T01:27:45Z [Term] id: CL:0002507 name: langerin-positive lymph node dendritic cell def: "A dermal dendritic cell isolated from skin draining lymph nodes that is langerin-positive, MHC-II-positive, and CD4-negative and CD8a-negative." [GOC:tfm, http://www.immgen.org/index_content.html] subset: human_subset subset: mouse_subset is_a: CL:0000990 {is_inferred="true"} ! conventional dendritic cell intersection_of: CL:0000990 ! conventional dendritic cell intersection_of: CL:4030046 PR:000001004 ! lacks_plasma_membrane_part CD4 molecule intersection_of: CL:4030046 PR:000001084 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD8 alpha chain intersection_of: RO:0002104 GO:0042613 ! has plasma membrane part MHC class II protein complex intersection_of: RO:0002104 PR:000001293 ! has plasma membrane part C-type lectin domain family 4 member K relationship: CL:4030046 PR:000001004 ! lacks_plasma_membrane_part CD4 molecule relationship: CL:4030046 PR:000001084 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD8 alpha chain relationship: RO:0002104 GO:0042613 ! has plasma membrane part MHC class II protein complex relationship: RO:0002104 PR:000001293 ! has plasma membrane part C-type lectin domain family 4 member K property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2011-01-21T01:57:00Z [Term] id: CL:0002508 name: langerin-negative, CD103-negative lymph node dendritic cell def: "A dermal dendritic cell isolated from skin draining lymph nodes that is langerin-negative, MHC-II-positive, and CD4-negative and CD8a-negative." [GOC:tfm, http://www.immgen.org/index_content.html] subset: human_subset subset: mouse_subset is_a: CL:0000990 {is_inferred="true"} ! conventional dendritic cell intersection_of: CL:0000990 ! conventional dendritic cell intersection_of: CL:4030046 PR:000001004 ! lacks_plasma_membrane_part CD4 molecule intersection_of: CL:4030046 PR:000001010 ! lacks_plasma_membrane_part integrin alpha-E intersection_of: CL:4030046 PR:000001084 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD8 alpha chain intersection_of: CL:4030046 PR:000001293 ! lacks_plasma_membrane_part C-type lectin domain family 4 member K intersection_of: RO:0002104 GO:0042613 ! has plasma membrane part MHC class II protein complex relationship: CL:4030046 PR:000001004 ! lacks_plasma_membrane_part CD4 molecule relationship: CL:4030046 PR:000001010 ! lacks_plasma_membrane_part integrin alpha-E relationship: CL:4030046 PR:000001084 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD8 alpha chain relationship: CL:4030046 PR:000001293 ! lacks_plasma_membrane_part C-type lectin domain family 4 member K relationship: RO:0002104 GO:0042613 ! has plasma membrane part MHC class II protein complex property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2011-01-21T02:13:58Z [Term] id: CL:0002509 name: CD103-positive, langerin-positive lymph node dendritic cell def: "A langerin-positive lymph node dendritic cell that is CD103-positive and CD11b-low." [GOC:tfm, http://www.immgen.org/index_content.html] subset: human_subset subset: mouse_subset is_a: CL:0002454 ! CD4-negative, CD8-alpha-negative, CD11b-positive dendritic cell is_a: CL:0002461 ! CD103-positive dendritic cell is_a: CL:0002507 {is_inferred="true"} ! langerin-positive lymph node dendritic cell intersection_of: CL:0002507 ! langerin-positive lymph node dendritic cell intersection_of: RO:0002104 PR:000001010 ! has plasma membrane part integrin alpha-E intersection_of: RO:0015016 PR:000001012 ! has low plasma membrane amount integrin alpha-M relationship: RO:0015016 PR:000001012 ! has low plasma membrane amount integrin alpha-M property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2011-01-21T02:07:54Z [Term] id: CL:0002510 name: CD103-negative, langerin-positive lymph node dendritic cell def: "A langerin-positive lymph node dendritic cell that is CD103-negative and CD11b-high." [GOC:tfm, http://www.immgen.org/index_content.html] subset: human_subset subset: mouse_subset is_a: CL:0002454 ! CD4-negative, CD8-alpha-negative, CD11b-positive dendritic cell is_a: CL:0002507 {is_inferred="true"} ! langerin-positive lymph node dendritic cell intersection_of: CL:0002507 ! langerin-positive lymph node dendritic cell intersection_of: CL:4030046 PR:000001010 ! lacks_plasma_membrane_part integrin alpha-E intersection_of: RO:0015015 PR:000001012 ! has high plasma membrane amount integrin alpha-M relationship: CL:4030046 PR:000001010 ! lacks_plasma_membrane_part integrin alpha-E relationship: RO:0015015 PR:000001012 ! has high plasma membrane amount integrin alpha-M property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2011-01-21T02:11:14Z [Term] id: CL:0002511 name: CD11b-low, CD103-negative, langerin-negative lymph node dendritic cell def: "A langerin-negative lymph node dendritic cell that is CD103-negative and CD11b-low." [GOC:tfm, http://www.immgen.org/index_content.html] subset: human_subset subset: mouse_subset is_a: CL:0002454 ! CD4-negative, CD8-alpha-negative, CD11b-positive dendritic cell is_a: CL:0002508 {is_inferred="true"} ! langerin-negative, CD103-negative lymph node dendritic cell intersection_of: CL:0002508 ! langerin-negative, CD103-negative lymph node dendritic cell intersection_of: RO:0015016 PR:000001012 ! has low plasma membrane amount integrin alpha-M relationship: RO:0015016 PR:000001012 ! has low plasma membrane amount integrin alpha-M property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2011-01-21T02:22:15Z [Term] id: CL:0002512 name: CD11b-high, CD103-negative, langerin-negative lymph node dendritic cell def: "A langerin-negative lymph node dendritic cell that is CD103-negative and CD11b-high." [GOC:tfm, http://www.immgen.org/index_content.html] subset: human_subset subset: mouse_subset is_a: CL:0002454 ! CD4-negative, CD8-alpha-negative, CD11b-positive dendritic cell is_a: CL:0002508 {is_inferred="true"} ! langerin-negative, CD103-negative lymph node dendritic cell intersection_of: CL:0002508 ! langerin-negative, CD103-negative lymph node dendritic cell intersection_of: RO:0015015 PR:000001012 ! has high plasma membrane amount integrin alpha-M relationship: RO:0015015 PR:000001012 ! has high plasma membrane amount integrin alpha-M property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2011-01-21T02:16:21Z [Term] id: CL:0002513 name: Vgamma5-positive CD8-alpha alpha positive gamma-delta intraepithelial T cell def: "A CD8-alpha alpha positive gamma-delta intraepithelial T cell that expresses a TCR encoded in part by the Vgamma5 gene segment." [GOC:tfm, http://www.immgen.org/index_content.html] subset: human_subset subset: mouse_subset synonym: "tgd.vg5+.IEL" EXACT [] is_a: CL:0000802 ! CD8-alpha alpha positive, gamma-delta intraepithelial T cell property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2011-01-24T10:22:18Z [Term] id: CL:0002514 name: Vgamma5-negative CD8-alpha alpha positive gamma-delta intraepithelial T cell def: "A CD8-alpha alpha positive gamma-delta intraepithelial T cell that does not express a TCR partially encoded by the Vgamma5 gene segment." [GOC:tfm, http://www.immgen.org/index_content.html] subset: human_subset subset: mouse_subset synonym: "tgd.vg5-.IEL" EXACT [] is_a: CL:0000802 ! CD8-alpha alpha positive, gamma-delta intraepithelial T cell property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2011-01-24T10:25:44Z [Term] id: CL:0002515 name: interrenal norepinephrine type cell def: "An interrenal chromaffin cell found in teleosts that contain heterogeneous vesicles with electron-dense granules located asymmetrically within the vesicular membrane." [GOC:MH, GOC:tfm, PMID:12668625] subset: human_subset subset: mouse_subset synonym: "interrenal noradrenaline type cell" EXACT [] synonym: "type n interrenal cell" EXACT [] is_a: CL:0000459 ! noradrenergic cell is_a: CL:0002516 ! interrenal chromaffin cell property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2011-02-08T10:11:55Z [Term] id: CL:0002516 name: interrenal chromaffin cell def: "A chromaffin cell interspersed among the interrenal epithelial layer of the anterior kidney of teloest fish." [GOC:MH, GOC:tfm, PMID:12668625] subset: human_subset subset: mouse_subset is_a: CL:0000166 ! chromaffin cell property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2011-02-08T10:21:35Z [Term] id: CL:0002517 name: interrenal epinephrin secreting cell def: "An interrenal chromaffin cell found in teleosts that contain small, homogeneous electron-lucent granules that are separated from the vesicular membrane by a visible halo." [GOC:MH, GOC:tfm, PMID:12668625] subset: human_subset subset: mouse_subset synonym: "interrenal adrenaline secreting cell" RELATED [] synonym: "type a interrenal cell" EXACT [] is_a: CL:0000454 ! epinephrine secreting cell is_a: CL:0002516 ! interrenal chromaffin cell property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2011-02-08T10:27:05Z [Term] id: CL:0002518 name: kidney epithelial cell def: "An epithelial cell of the kidney." [GOC:tfm, KUPO:SJ] subset: cellxgene_subset subset: human_subset subset: mouse_subset xref: KUPO:0001019 xref: ZFA:0009374 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000066 ! epithelial cell is_a: CL:1000497 {is_inferred="true"} ! kidney cell intersection_of: CL:0000066 ! epithelial cell intersection_of: BFO:0000050 UBERON:0002113 ! part of kidney property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2011-02-08T10:46:34Z [Term] id: CL:0002519 name: interrenal epithelial cell def: "An interrenal epithelial kidney cell is an epithelial cell found in the anterior kidney of teleosts fish. This cell type is arranged in layers around the posterior cardinal vein and contains many mitochondria with tubulovesicular cristae. Interrenal chromaffin cells are interspersed among the tissue layer created by this cell type." [GOC:mh, GOC:tfm, PMID:12668625] subset: human_subset subset: mouse_subset is_a: CL:0002518 ! kidney epithelial cell property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2011-02-08T11:03:32Z [Term] id: CL:0002520 name: nephrocyte def: "An insect excretory cell that regulates hemolymph composition by filtration and filtrate endocytosis." [GOC:tfm, PMID:19783135] xref: BTO:0004597 is_a: CL:0002522 ! renal filtration cell relationship: RO:0002162 NCBITaxon:50557 ! in taxon Insecta property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2011-02-08T01:34:56Z [Term] id: CL:0002521 name: subcutaneous adipocyte def: "An adipocyte that is part of subcutaneous adipose tissue." [GOC:tfm] subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "subcutaneous fat cell" EXACT [] is_a: CL:0000136 {is_inferred="true"} ! adipocyte intersection_of: CL:0000136 ! adipocyte intersection_of: BFO:0000050 UBERON:0002190 ! part of subcutaneous adipose tissue relationship: BFO:0000050 UBERON:0002190 ! part of subcutaneous adipose tissue property_value: RO:0002175 NCBITaxon:9606 property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0002521" xsd:string {name="subcutaneous adipocyte on CELLxGENE CellGuide"} property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 property_value: terms:description "Subcutaneous fat cells, also known as adipocytes, reside under the skin, in the subcutaneous layer of our body. These cells primarily function as reserves for energy due to their ability to store lipids, particularly triglycerides, efficiently. Subcutaneous fat cells make up the most significant part of the adipose tissue, which provides insulation, cushioning, and serves as an energy reserve for individuals. The location of these cells varies with gender; typically, in males these cells are found in the area of the abdomen, whereas, in females, they are found in the thighs and the buttock region.\nThese cells play an integral role in maintaining metabolic homeostasis. Beyond energy storage, subcutaneous fat cells are also engaged in numerous physiological processes such as maintaining body temperature, protecting the body from mechanical trauma, and functioning as an endocrine organ. They produce and secrete various bioactive molecules known as adipokines which have wide-ranging impacts on various bodily processes, including regulation of appetite, insulin sensitivity, inflammation, and immune function.\nSubcutaneous fat cells have a characteristic shape, being large, spherical, and filled with a large lipid droplet, unlike other cell types that contain smaller lipid droplets scattered throughout the cytoplasm. The diameter of these cells can range from 30 to over 300 micrometers, significantly larger than most other cells in the body. Of note, these cells also demonstrate a unique property called plasticity. They are able to change their volume dramatically, expanding to store more fat as it is taken up from the bloodstream, and shrinking when fats are released to provide energy.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1016/j.cell.2021.12.016", xref="DOI:10.1038/nature05483", xref="DOI:10.1152/ajpregu.00257.2017", xref="DOI:10.3389/fcvm.2020.00022", xref="DOI:10.5114/aoms.2013.33181"} creation_date: 2011-02-21T02:51:22Z [Term] id: CL:0002522 name: renal filtration cell def: "A renal filtration cell is a specialized cell of the renal system that filter fluids by charge, size or both." [GOC:tfm] subset: human_subset subset: mouse_subset is_a: CL:0000255 ! eukaryotic cell is_a: CL:0000424 ! excretory cell relationship: BFO:0000050 UBERON:0001008 ! part of renal system property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2011-02-08T01:37:59Z [Term] id: CL:0002523 name: mesonephric podocyte def: "A specialized epithelial cell that contains \"feet\" that interdigitate with the \"feet\" of other glomerular epithelial cells in the mesonephros." [GOC:tfm] subset: human_subset subset: mouse_subset synonym: "mesonephric glomerular visceral epithelial cell" EXACT [ZFA:0001674] is_a: CL:0000653 ! podocyte intersection_of: CL:0000653 ! podocyte intersection_of: BFO:0000050 UBERON:0000080 ! part of mesonephros relationship: BFO:0000050 UBERON:0000080 ! part of mesonephros property_value: terms:contributor https://orcid.org/0000-0002-2244-7917 property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2011-02-08T01:58:30Z [Term] id: CL:0002524 name: disseminated nephrocyte def: "A disseminated nephrocyte is a nephrocyte that filters hemolymph and is found at scattered locations in the fat body or other tissues." [GOC:tfm, PMID:19783135] is_a: CL:0002520 ! nephrocyte property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2011-02-08T02:07:33Z [Term] id: CL:0002525 name: metanephric podocyte def: "A specialized epithelial cell that contains \"feet\" that interdigitate with the \"feet\" of other glomerular epithelial cells in the metanephros." [GOC:tfm] subset: human_subset subset: mouse_subset synonym: "metanephric glomerular visceral epithelial cell" EXACT [doi:10.1007/s004180050142] is_a: CL:0000653 ! podocyte intersection_of: CL:0000653 ! podocyte intersection_of: BFO:0000050 UBERON:0000081 ! part of metanephros relationship: BFO:0000050 UBERON:0000081 ! part of metanephros property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2011-02-08T02:02:13Z [Term] id: CL:0002526 name: CD14-positive dermal dendritic cell def: "A dermal dendritic cell that is CD1a-negative and CD14-positive." [GOC:dsd, PMID:19236899, PMID:20309010] comment: They are also CD11c-positive, CD40-positive, CD85j-positive (ILT-2), CD163-positive, CD205-positive (DEC205), CD207-negative (langerin), CD209-positive (DC-SIGN), CD274-positive (PD-L1), CD324-negative (E-cadherin), Factor XIIIa-positive, LOX-I-positive, CLEC6-positive, Dectin-1-positive, and DCIR-positive. Upon stimulation, these cells are capable of producing IL1-beta, IL6, IL8, IL10, IL12p40, IL19, IL20, IL24, TGF-beta, TNF-alpha, GM-CSF, and MCP1. They reside in the dermis. subset: human_subset subset: mouse_subset synonym: "CD14+ dermal DC" EXACT [] is_a: CL:0001006 {is_inferred="true"} ! dermal dendritic cell intersection_of: CL:0001006 ! dermal dendritic cell intersection_of: CL:4030046 PR:000002025 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD1a intersection_of: RO:0002104 PR:000001889 ! has plasma membrane part CD14 molecule intersection_of: RO:0002215 GO:0045191 ! capable of regulation of isotype switching relationship: CL:4030046 PR:000002025 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD1a relationship: RO:0002104 PR:000001889 ! has plasma membrane part CD14 molecule relationship: RO:0002215 GO:0045191 ! capable of regulation of isotype switching [Term] id: CL:0002527 name: immature CD14-positive dermal dendritic cell def: "An immature CD14-positive dermal dendritic cell is CD80-low, CD86-low, and MHCII-low." [GOC:dsd] subset: human_subset subset: mouse_subset is_a: CL:0001009 ! immature dermal dendritic cell is_a: CL:0002526 {is_inferred="true"} ! CD14-positive dermal dendritic cell intersection_of: CL:0002526 ! CD14-positive dermal dendritic cell intersection_of: RO:0015016 GO:0042613 ! has low plasma membrane amount MHC class II protein complex intersection_of: RO:0015016 PR:000001412 ! has low plasma membrane amount CD86 molecule intersection_of: RO:0015016 PR:000001438 ! has low plasma membrane amount CD80 molecule [Term] id: CL:0002528 name: mature CD14-positive dermal dendritic cell def: "A mature CD14-positive dermal dendritic cell is CD80-high, CD86-high, MHCII-high and is CD83-positive." [GOC:dsd] subset: human_subset subset: mouse_subset is_a: CL:0001010 ! mature dermal dendritic cell is_a: CL:0002526 {is_inferred="true"} ! CD14-positive dermal dendritic cell intersection_of: CL:0002526 ! CD14-positive dermal dendritic cell intersection_of: RO:0002104 PR:000001310 ! has plasma membrane part CD83 molecule intersection_of: RO:0015015 GO:0042613 ! has high plasma membrane amount MHC class II protein complex intersection_of: RO:0015015 PR:000001412 ! has high plasma membrane amount CD86 molecule intersection_of: RO:0015015 PR:000001438 ! has high plasma membrane amount CD80 molecule relationship: RO:0002202 CL:0002527 ! develops from immature CD14-positive dermal dendritic cell [Term] id: CL:0002529 name: CD1a-positive dermal dendritic cell def: "A dermal dendritic cell that is CD1a-positive and CD14-negative." [GOC:dsd, PMID:20309010] comment: Reside in the dermis. They are also CD11c-positive, CD40-positive, CD207-negative (langerin), CD209-negative (DC-SIGN), and CD324-negative (E-cadherin). When activated, they are capable of producing CXCL8 (IL-8) and IL-15. Possibly a precursor of Langerhans cells or equivalent of langerin-positive dermal DCs in the mouse. subset: human_subset subset: mouse_subset synonym: "CD1a+ dermal DC" EXACT [] is_a: CL:0001006 {is_inferred="true"} ! dermal dendritic cell intersection_of: CL:0001006 ! dermal dendritic cell intersection_of: RO:0002104 PR:000002025 ! has plasma membrane part T-cell surface glycoprotein CD1a relationship: RO:0002104 PR:000002025 ! has plasma membrane part T-cell surface glycoprotein CD1a [Term] id: CL:0002530 name: immature CD1a-positive dermal dendritic cell def: "An immature CD1a-positive dermal dendritic cell is CD80-low, CD86-low, and MHCII-low." [GOC:dsd] subset: human_subset subset: mouse_subset is_a: CL:0001009 ! immature dermal dendritic cell is_a: CL:0002529 {is_inferred="true"} ! CD1a-positive dermal dendritic cell intersection_of: CL:0002529 ! CD1a-positive dermal dendritic cell intersection_of: RO:0015016 GO:0042613 ! has low plasma membrane amount MHC class II protein complex intersection_of: RO:0015016 PR:000001412 ! has low plasma membrane amount CD86 molecule intersection_of: RO:0015016 PR:000001438 ! has low plasma membrane amount CD80 molecule [Term] id: CL:0002531 name: mature CD1a-positive dermal dendritic cell def: "A mature CD1a-positive dermal dendritic cell is CD80-high, CD83-positive, CD86-high, and MHCII-high." [GOC:dsd] subset: human_subset subset: mouse_subset is_a: CL:0001010 ! mature dermal dendritic cell is_a: CL:0002529 {is_inferred="true"} ! CD1a-positive dermal dendritic cell intersection_of: CL:0002529 ! CD1a-positive dermal dendritic cell intersection_of: RO:0002104 PR:000001310 ! has plasma membrane part CD83 molecule intersection_of: RO:0015015 GO:0042613 ! has high plasma membrane amount MHC class II protein complex intersection_of: RO:0015015 PR:000001412 ! has high plasma membrane amount CD86 molecule intersection_of: RO:0015015 PR:000001438 ! has high plasma membrane amount CD80 molecule relationship: RO:0002202 CL:0002530 ! develops from immature CD1a-positive dermal dendritic cell [Term] id: CL:0002532 name: CD16-positive myeloid dendritic cell def: "A myeloid dendritic cell found in the blood that is CD16-positive." [GOC:dsd, PMID:17332250] comment: Normally represent 65-75% of peripheral blood mDCs (human). They are also CD281-positive (TLR1), CD282-positive (TLR2), CD284-positive (TLR4), CD285-positive (TLR5), CD286-positive (TLR6), CD288-positive (TLR8), CD289-positive (TLR9), and CD290-positive (TLR10) by RT-PCR [PMID:17332250]. Upon TLR stimulation, these cells are potent producers of TNF-alpha, while producing little CXCL8 (IL8). subset: human_subset subset: mouse_subset synonym: "CD16+ mDC" EXACT [] synonym: "CD16-mDC" EXACT [] is_a: CL:0000782 {is_inferred="true"} ! myeloid dendritic cell intersection_of: CL:0000782 ! myeloid dendritic cell intersection_of: RO:0002104 PR:000001483 ! has plasma membrane part low affinity immunoglobulin gamma Fc region receptor III intersection_of: RO:0002215 GO:0032640 ! capable of tumor necrosis factor production relationship: RO:0002104 PR:000001483 ! has plasma membrane part low affinity immunoglobulin gamma Fc region receptor III relationship: RO:0002215 GO:0032640 ! capable of tumor necrosis factor production [Term] id: CL:0002533 name: immature CD16-positive myeloid dendritic cell def: "An immature CD16-positive myeloid dendritic cell is CD80-low, CD86-low, and MHCII-low." [GOC:dsd] subset: human_subset subset: mouse_subset is_a: CL:0000840 ! immature conventional dendritic cell is_a: CL:0002532 {is_inferred="true"} ! CD16-positive myeloid dendritic cell intersection_of: CL:0002532 ! CD16-positive myeloid dendritic cell intersection_of: RO:0015016 GO:0042613 ! has low plasma membrane amount MHC class II protein complex intersection_of: RO:0015016 PR:000001412 ! has low plasma membrane amount CD86 molecule intersection_of: RO:0015016 PR:000001438 ! has low plasma membrane amount CD80 molecule [Term] id: CL:0002534 name: mature CD16-positive myeloid dendritic cell def: "A mature CD16-positive myeloid dendritic cell is CD80-high, CD83-positive, CD86-high, and MHCII-high." [GOC:dsd] subset: human_subset subset: mouse_subset is_a: CL:0000841 ! mature conventional dendritic cell is_a: CL:0002532 {is_inferred="true"} ! CD16-positive myeloid dendritic cell intersection_of: CL:0002532 ! CD16-positive myeloid dendritic cell intersection_of: RO:0002104 PR:000001310 ! has plasma membrane part CD83 molecule intersection_of: RO:0015015 GO:0042613 ! has high plasma membrane amount MHC class II protein complex intersection_of: RO:0015015 PR:000001412 ! has high plasma membrane amount CD86 molecule intersection_of: RO:0015015 PR:000001438 ! has high plasma membrane amount CD80 molecule relationship: RO:0002202 CL:0002533 ! develops from immature CD16-positive myeloid dendritic cell [Term] id: CL:0002535 name: epithelial cell of cervix def: "An epithelial cell of the cervix." [GOC:tfm] subset: human_subset subset: mouse_subset synonym: "cervical canal epithelial cell" EXACT [GOC:tfm] synonym: "cervical canal of uterus epithelial cell" EXACT [GOC:tfm] synonym: "cervix epithelial cell" EXACT [GOC:tfm] synonym: "cervix of uterus epithelial cell" EXACT [GOC:tfm] synonym: "epithelial cell of cervical canal" EXACT [GOC:tfm] synonym: "epithelial cell of cervical canal of uterus" EXACT [GOC:tfm] synonym: "epithelial cell of cervix of uterus" EXACT [GOC:tfm] synonym: "epithelial cell of neck of uterus" EXACT [GOC:tfm] synonym: "epithelial cell of uterine cervix" EXACT [GOC:tfm] synonym: "neck of uterus epithelial cell" EXACT [GOC:tfm] synonym: "uterine cervix epithelial cell" EXACT [GOC:tfm] is_a: CL:0002149 ! epithelial cell of uterus intersection_of: CL:0000066 ! epithelial cell intersection_of: BFO:0000050 UBERON:0000002 ! part of uterine cervix relationship: BFO:0000050 UBERON:0004801 ! part of cervix epithelium property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2011-02-24T08:20:08Z [Term] id: CL:0002536 name: epithelial cell of amnion def: "An epithelial cell that is part of the amnion." [GOC:tfm] subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "amniotic epithelial cell" EXACT [] is_a: CL:0000066 ! epithelial cell intersection_of: CL:0000066 ! epithelial cell intersection_of: BFO:0000050 UBERON:0000305 ! part of amnion relationship: BFO:0000050 UBERON:0000305 ! part of amnion property_value: RO:0002175 NCBITaxon:9606 property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2011-02-28T12:38:01Z [Term] id: CL:0002537 name: amnion mesenchymal stem cell def: "A mesenchymal stem cell of the amnion membrane." [GOC:tfm, PMID:20446274, PMID:21339039] subset: human_subset subset: mouse_subset synonym: "amniotic membrane stem cell" EXACT [] is_a: CL:0000134 ! mesenchymal stem cell intersection_of: CL:0000134 ! mesenchymal stem cell intersection_of: BFO:0000050 UBERON:0000305 ! part of amnion relationship: BFO:0000050 UBERON:0000305 ! part of amnion property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2011-02-28T12:44:24Z [Term] id: CL:0002538 name: intrahepatic cholangiocyte def: "An epithelial cell of the intrahepatic portion of the bile duct. These cells are flattened or cuboidal in shape, and have a small nuclear-to-cytoplasmic ratio relative to large/extrahepatic cholangiocytes." [GOC:tfm, PMID:23720296] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "small bile duct cholangiocyte" EXACT [PMID:23720296] xref: ZFA:0009379 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:1000488 {is_inferred="true"} ! cholangiocyte intersection_of: CL:1000488 ! cholangiocyte intersection_of: BFO:0000050 UBERON:0004823 ! part of intrahepatic bile duct epithelium relationship: BFO:0000050 UBERON:0004823 ! part of intrahepatic bile duct epithelium property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0002538" xsd:string {name="intrahepatic cholangiocyte on CELLxGENE CellGuide"} property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 property_value: terms:description "Intrahepatic cholangiocytes represent a subset of the biliary epithelial cells that form a network of tubes in the liver called the biliary tree The intrahepatic cholangiocytes reside specifically in the intrahepatic bile ducts and play a crucial role in liver physiology and bile production and secretion, thereby aiding in the digestion and absorption of fats in the small intestine. These specific cholangiocytes arise from bipotent hepatoblasts, whereas extrahepatic cholangiocytes share an embryologic origin with the ventral pancreas.\nRecent research suggests that there is also heterogeneity within populations of intrahepatic cholangiocytes with different transcriptional profiles, proliferative capacity, and biological function; for example, subpopulations differ in calcium-mobilizing receptors.\nThe primary function of intrahepatic cholangiocytes is related to bile formation and maintenance of its flow. In addition to their secretory and absorptive activities, they are involved in the regulation of bile composition, volume, and alkalinization, contributing to the neutralization of the acidic chyme (partly digested food) that enters the intestine from the stomach. Intrahepatic cholangiocytes are also recognized for their role in liver regeneration and repair, often proliferating in response to injury. \nIntrahepatic cholangiocytes take part in certain pathological conditions, like primary biliary cirrhosis and cholangiocarcinoma. Changes in these cells often lead to abnormalities in bile formation and transport, causing cholestatic liver diseases. Overall, the primary and secondary functional activities of intrahepatic cholangiocytes are vital in maintaining liver function, digestive processes, and contributing to the body's response to liver injury.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1002/hep.31252", xref="DOI:10.1016/j.ajpath.2023.02.012", xref="DOI:10.1016/j.biocel.2010.06.020", xref="DOI:10.1016/j.gastha.2022.07.015"} creation_date: 2011-02-28T01:20:20Z [Term] id: CL:0002539 name: aortic smooth muscle cell def: "A smooth muscle cell of the aorta." [GOC:tfm] subset: cellxgene_subset subset: human_subset subset: mouse_subset xref: BTO:0004577 is_a: CL:0019018 ! blood vessel smooth muscle cell intersection_of: CL:0000359 ! vascular associated smooth muscle cell intersection_of: BFO:0000050 UBERON:0004178 ! part of aorta smooth muscle tissue relationship: BFO:0000050 UBERON:0004178 ! part of aorta smooth muscle tissue property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0002539" xsd:string {name="aortic smooth muscle cell on CELLxGENE CellGuide"} property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 property_value: terms:description "Aortic smooth muscle cells are specialized and highly differentiated muscle cells that are located in the tunica media layer of the aorta. They consist of spindle-shaped cells with a centrally located nucleus. These cells are rich in actin and myosin, muscle contractile proteins, that allow them to exert force and change shape. \nAortic smooth muscle cells play a vital role in maintaining blood pressure and circulation, and are essential for vascular integrity and function. The primary function of these cells is contraction and relaxation, which enables the regulation of blood flow and pressure in the aorta, and helps in the distribution of oxygen and nutrients throughout the body.\nAdditionally, a critical characteristic of smooth muscle cells is their plasticity. They can undergo phenotypic modulation in response to changes in their environment or vascular injury, switching from a contractile to a synthetic phenotype. The contractile phenotype is characterized by high contractility and low proliferation rate, while the synthetic phenotype is marked by increased cell proliferation and matrix synthesis but reduced contractile function.\nAortic smooth muscle cells have a significant role in the physiological and pathological processes of the cardiovascular system. In the normal physiological state, they contribute to the elasticity and flexibility of the aorta. Conversely, in pathological states, changes in the function and structure of aortic smooth muscle cells are connected with various vascular diseases, including atherosclerosis, hypertension, and aneurysm.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1016/j.devcel.2005.05.017", xref="DOI:10.1111/febs.12414", xref="DOI:10.7150/ijbs.49871", xref="https://training.seer.cancer.gov/anatomy/cells_tissues_membranes/tissues/muscle.html", xref="https://www.sciencedirect.com/topics/medicine-and-dentistry/aortic-smooth-muscle-cell"} creation_date: 2011-02-28T01:42:12Z [Term] id: CL:0002540 name: mesenchymal stem cell of the bone marrow def: "A mesenchymal stem cell that is part of the bone marrow." [GOC:tfm] subset: human_subset subset: mouse_subset is_a: CL:0000134 ! mesenchymal stem cell is_a: CL:0002092 ! bone marrow cell intersection_of: CL:0000134 ! mesenchymal stem cell intersection_of: BFO:0000050 UBERON:0002371 ! part of bone marrow property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2011-02-28T01:47:47Z [Term] id: CL:0002541 name: chorionic membrane mesenchymal stem cell def: "A mesenchymal stem cell of the chorionic membrane." [GOC:tfm] subset: human_subset subset: mouse_subset is_a: CL:0000134 ! mesenchymal stem cell intersection_of: CL:0000134 ! mesenchymal stem cell intersection_of: BFO:0000050 UBERON:0003124 ! part of chorion membrane relationship: BFO:0000050 UBERON:0003124 ! part of chorion membrane property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2011-02-28T03:04:35Z [Term] id: CL:0002543 name: vein endothelial cell alt_id: CL:1000393 def: "An endothelial cell that is part of the vein." [GOC:tfm] subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "endothelial cell of vein" EXACT [] synonym: "venous endothelial cell" EXACT [] xref: FMA:62104 xref: KUPO:0001099 is_a: CL:0000071 {is_inferred="true"} ! blood vessel endothelial cell intersection_of: CL:0000071 ! blood vessel endothelial cell intersection_of: BFO:0000050 UBERON:0001638 ! part of vein relationship: BFO:0000050 UBERON:0001638 ! part of vein property_value: RO:0002175 NCBITaxon:9606 property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0002543" xsd:string {name="vein endothelial cell on CELLxGENE CellGuide"} property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 property_value: terms:description "Vein endothelial cells form a thin layer of squamous cells, the endothelium, lining the interior surface of veins throughout the body. They shape the inner cellular lining of the entire vascular system, including the heart, playing a crucial role in blood circulation. The unique characteristic compact arrangement of these cells enables veins to act as a barrier between the blood (that can contain foreign substances) and the surrounding venous tissue and maintain the integrity of the vascular system.\nThe primary function of vein endothelial cells is to control the exchange of substances between the bloodstream and the surrounding tissues. They facilitate selective transportation of molecules depending on their size and solubility, including gases, nutrients, hormones, and waste products. Vein endothelial cells also play a protective role by inhibiting the translocation of toxins or pathogens from blood to tissues. Additionally, these cells are involved in blood coagulation and inflammation response, primarily by producing substances that inhibit blood clot formation under normal conditions and initiating clotting when necessary.\nAnother significant function of vein endothelial cells is the regulation of blood flow and blood pressure. They produce and release several substances, including nitric oxide and prostacyclin, which help in controlling vasodilation and vasoconstriction, thereby regulating blood pressure. These cells are also responsible for angiogenesis, the formation of new blood vessels, which is crucial during wound healing and in the formation of granulation tissue. Consequently, any dysfunction in vein endothelial cells can lead to severe health problems like atherosclerosis, hypertension, and thrombosis.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1007/s00441-008-0706-5", xref="DOI:10.1038/s41569-022-00770-1", xref="DOI:10.1038/s41598-021-01360-w", xref="DOI:10.3390/ijms20184411"} creation_date: 2011-02-28T03:48:11Z [Term] id: CL:0002544 name: aortic endothelial cell def: "An arterial endothelial cell that is part of the aorta endothelium." [GOC:tfm] subset: cellxgene_subset subset: human_subset subset: mouse_subset xref: BTO:0003245 xref: CALOHA:TS-0047 is_a: CL:1000413 ! endothelial cell of artery property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2011-02-28T03:54:42Z [Term] id: CL:0002545 name: thoracic aorta endothelial cell def: "An endothelial cell that is part of the thoracic endothelium." [GOC:tfm] subset: human_subset subset: mouse_subset is_a: CL:0002544 {is_inferred="true"} ! aortic endothelial cell intersection_of: CL:0002544 ! aortic endothelial cell intersection_of: BFO:0000050 UBERON:0001515 ! part of thoracic aorta relationship: BFO:0000050 UBERON:0001515 ! part of thoracic aorta property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2011-02-28T03:59:09Z [Term] id: CL:0002546 name: embryonic blood vessel endothelial progenitor cell def: "An endothelial progenitor cell that participates in angiogenesis during development." [GOC:tfm] comment: See CL:0002619. subset: cellxgene_subset subset: human_subset subset: mouse_subset xref: ZFA:0005773 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000222 ! mesodermal cell property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2011-02-28T04:20:39Z [Term] id: CL:0002547 name: fibroblast of the aortic adventitia def: "A fibroblast of the aortic adventitia." [GOC:tfm] subset: cellxgene_subset subset: human_subset subset: mouse_subset is_a: CL:1000306 {is_inferred="true"} ! fibroblast of tunica adventitia of artery intersection_of: CL:1000306 ! fibroblast of tunica adventitia of artery intersection_of: BFO:0000050 UBERON:0004664 ! part of aorta tunica adventitia relationship: BFO:0000050 UBERON:0004664 ! part of aorta tunica adventitia property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2011-02-28T04:43:41Z [Term] id: CL:0002548 name: fibroblast of cardiac tissue def: "A fibroblast that is part of the heart." [GOC:tfm] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "cardiac fibroblast" EXACT [] is_a: CL:0000057 {is_inferred="true"} ! fibroblast is_a: CL:0002494 {is_inferred="true"} ! cardiocyte intersection_of: CL:0000057 ! fibroblast intersection_of: BFO:0000050 UBERON:0000948 ! part of heart relationship: BFO:0000050 UBERON:0000948 ! part of heart property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0002548" xsd:string {name="fibroblast of cardiac tissue on CELLxGENE CellGuide"} property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 property_value: terms:description "Fibroblasts of cardiac tissue, or cardiac fibroblasts, are critical cells involved in the normal function and repair of the heart. They are essentially a type of non-muscle cell that are integral to the connective tissue and structural integrity of the heart. The primary role of cardiac fibroblasts is the synthesis and deposition of extracellular matrix (ECM) components. They synthesize a variety of ECM proteins, such as collagen, fibronectin, and elastin, forming a distinctive three-dimensional network that provides both mechanical and biochemical support for the cardiomyocytes.\nCardiac fibroblasts also participate in crucial cellular communication within the myocardium - the muscular tissue of the heart responsible for pumping blood. They engage in intense cross-talk with cardiomyocytes and endothelial cells, influencing cell survival, growth, differentiation, and tissue repair processes. Particularly notable is their role in cardiac response to injury, such as myocardial infarction, where they proliferate intensely, and subsequently differentiate into myofibroblasts, contributing to scar formation and remodeling of cardiac tissue post-injury.\nMoreover, during pathological conditions of the heart, including cardiac fibrosis and heart failure, these fibroblasts can undergo phenotypic transformation into myofibroblasts, leading to an overproduction of ECM components and resulting in stiffening of the cardiac tissue. Over time, this diminishes the heart's ability to pump efficiently, sometimes leading to heart failure. Recent studies have also implicated abnormal behavior of cardiac fibroblasts in arrhythmogenesis.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1093/cvr/cvaa324", xref="DOI:10.1126/science.adh9925", xref="DOI:10.1161/CIRCRESAHA.109.209809", xref="DOI:10.1186/1755-1536-5-15", xref="DOI:10.1253/circj.CJ-16-1003"} creation_date: 2011-02-28T04:57:44Z [Term] id: CL:0002549 name: fibroblast of choroid plexus def: "A fibroblast that is part of the choroid plexus." [GOC:tfm] subset: cellxgene_subset subset: human_subset subset: mouse_subset is_a: CL:0000057 {is_inferred="true"} ! fibroblast is_a: CL:0002319 ! neural cell intersection_of: CL:0000057 ! fibroblast intersection_of: BFO:0000050 UBERON:0001886 ! part of choroid plexus relationship: BFO:0000050 UBERON:0001886 ! part of choroid plexus property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2011-02-28T05:01:39Z [Term] id: CL:0002550 name: fibroblast of the conjunctiva def: "A fibroblast that is part of the conjuctiva of the eye." [GOC:tfm] subset: human_subset subset: mouse_subset is_a: CL:0000057 ! fibroblast intersection_of: CL:0000057 ! fibroblast intersection_of: BFO:0000050 UBERON:0001811 ! part of conjunctiva relationship: BFO:0000050 UBERON:0001811 ! part of conjunctiva property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2011-02-28T05:03:44Z [Term] id: CL:0002551 name: fibroblast of dermis def: "Any skin fibroblast that is part of some dermis." [FBC:Autogenerated] subset: cellxgene_subset subset: human_subset subset: mouse_subset is_a: CL:0002620 {is_inferred="true"} ! skin fibroblast intersection_of: CL:0002620 ! skin fibroblast intersection_of: BFO:0000050 UBERON:0002067 ! part of dermis relationship: BFO:0000050 UBERON:0002067 ! part of dermis property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2011-02-28T05:05:33Z [Term] id: CL:0002552 name: fibroblast of gingiva def: "Any fibroblast that is part of some gingiva." [FBC:Autogenerated] subset: cellxgene_subset subset: human_subset subset: mouse_subset is_a: CL:0000057 {is_inferred="true"} ! fibroblast intersection_of: CL:0000057 ! fibroblast intersection_of: BFO:0000050 UBERON:0001828 ! part of gingiva relationship: BFO:0000050 UBERON:0001828 ! part of gingiva property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2011-02-28T05:09:12Z [Term] id: CL:0002553 name: fibroblast of lung def: "A fibroblast that is part of lung." [GOC:tfm] subset: cellxgene_subset subset: human_subset subset: mouse_subset xref: BTO:0000764 xref: CALOHA:TS-0575 is_a: CL:0000057 {is_inferred="true"} ! fibroblast intersection_of: CL:0000057 ! fibroblast intersection_of: BFO:0000050 UBERON:0002048 ! part of lung relationship: BFO:0000050 UBERON:0002048 ! part of lung property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2011-02-28T05:11:03Z [Term] id: CL:0002554 name: fibroblast of lymphatic vessel def: "A fibroblast of the lymphatic system." [GOC:tfm] subset: cellxgene_subset subset: human_subset subset: mouse_subset is_a: CL:0000057 {is_inferred="true"} ! fibroblast intersection_of: CL:0000057 ! fibroblast intersection_of: BFO:0000050 UBERON:0001473 ! part of lymphatic vessel relationship: BFO:0000050 UBERON:0001473 ! part of lymphatic vessel property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2011-02-28T05:16:18Z [Term] id: CL:0002555 name: fibroblast of mammary gland def: "A fibroblast that is part of the mammary gland." [GOC:tfm] subset: cellxgene_subset subset: human_subset subset: mouse_subset is_a: CL:0000057 {is_inferred="true"} ! fibroblast intersection_of: CL:0000057 ! fibroblast intersection_of: BFO:0000050 UBERON:0001911 ! part of mammary gland relationship: BFO:0000050 UBERON:0001911 ! part of mammary gland property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0002555" xsd:string {name="fibroblast of mammary gland on CELLxGENE CellGuide"} property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 property_value: terms:description "Fibroblasts of the mammary gland, often referred to as mammary fibroblasts, are a specialized type of cell located within the connective tissue of the mammary glands. These cells are integral to the structure and composition of the gland and are one of its primary cell types, specializing in the production of the extracellular matrix and collagen. They are involved in tissue remodeling, shaping the structure and maintaining the integrity of the mammary tissue by providing necessary rigidity and elasticity through their production of structural proteins. \nThese cells also play a crucial role in mammary gland development and lactation. During mammary gland development, fibroblasts play a significant role in the induction of branching morphogenesis, which is vital for establishing proper ductal architecture. They also support the immune response within the mammary gland by producing and secreting cytokines and growth factors. \nImportantly, mammary fibroblasts are important in the context of breast cancer. Changes in the characteristics and behavior of these fibroblasts, often spurred by interactions with tumor cells, can promote cancer progression and metastasis.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1016/j.bbadis.2012.10.013", xref="DOI:10.1016/j.canlet.2012.06.014", xref="DOI:10.1038/onc.2017.65", xref="DOI:10.1089/jir.2014.0026", xref="DOI:10.3390/jcm11030799"} creation_date: 2011-02-28T05:18:38Z [Term] id: CL:0002556 name: fibroblast of periodontium def: "A fibroblast of the periodontium." [GOC:tfm] subset: human_subset subset: mouse_subset is_a: CL:0000057 {is_inferred="true"} ! fibroblast intersection_of: CL:0000057 ! fibroblast intersection_of: BFO:0000050 UBERON:0001758 ! part of periodontium relationship: BFO:0000050 UBERON:0001758 ! part of periodontium property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2011-02-28T05:19:48Z [Term] id: CL:0002557 name: fibroblast of pulmonary artery def: "A fibroblast of pulmonary artery." [GOC:tfm] subset: human_reference_atlas subset: human_subset subset: mouse_subset is_a: CL:0000057 {is_inferred="true"} ! fibroblast intersection_of: CL:0000057 ! fibroblast intersection_of: BFO:0000050 UBERON:0002012 ! part of pulmonary artery relationship: BFO:0000050 UBERON:0002012 ! part of pulmonary artery property_value: RO:0002175 NCBITaxon:9606 property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2011-02-28T05:22:27Z [Term] id: CL:0002558 name: fibroblast of villous mesenchyme def: "A fibroblast that is part of villous mesenchyme." [GOC:tfm] subset: human_reference_atlas subset: human_subset subset: mouse_subset is_a: CL:0000057 ! fibroblast relationship: BFO:0000050 UBERON:0001987 ! part of placenta property_value: RO:0002175 NCBITaxon:9606 property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2011-02-28T05:24:28Z [Term] id: CL:0002559 name: hair follicle cell def: "An animal cell that is part of a hair follicle." [GOC:tfm] subset: human_subset subset: mouse_subset is_a: CL:0000255 ! eukaryotic cell intersection_of: CL:0000000 ! cell intersection_of: BFO:0000050 UBERON:0002073 ! part of hair follicle relationship: BFO:0000050 UBERON:0002073 ! part of hair follicle property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2011-03-01T04:11:01Z [Term] id: CL:0002560 name: inner root sheath cell def: "An epithelial cell that resides in the inner root sheath of the hair follicle." [GOC:tfm] subset: human_subset subset: mouse_subset is_a: CL:0000362 ! epidermal cell is_a: CL:0002559 {is_inferred="true"} ! hair follicle cell intersection_of: CL:0002559 ! hair follicle cell intersection_of: BFO:0000050 UBERON:0005941 ! part of hair inner root sheath relationship: BFO:0000050 UBERON:0005941 ! part of hair inner root sheath property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2011-03-01T04:27:51Z [Term] id: CL:0002561 name: outer root sheath cell def: "An epithelial cell that is part of the outer root sheath." [GOC:tfm] subset: human_subset subset: mouse_subset is_a: CL:0000362 ! epidermal cell is_a: CL:0002559 {is_inferred="true"} ! hair follicle cell intersection_of: CL:0000066 ! epithelial cell intersection_of: BFO:0000050 UBERON:0005942 ! part of hair outer root sheath relationship: BFO:0000050 UBERON:0005942 ! part of hair outer root sheath property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2011-03-01T04:29:47Z [Term] id: CL:0002562 name: hair germinal matrix cell def: "An epidermal cell that is part of the germinal matrix." [GOC:tfm] subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "trichocyte" EXACT [] is_a: CL:0000362 {is_inferred="true"} ! epidermal cell is_a: CL:0002559 ! hair follicle cell intersection_of: CL:0000362 ! epidermal cell intersection_of: BFO:0000050 UBERON:0006004 ! part of hair follicle matrix region relationship: BFO:0000050 UBERON:0006004 ! part of hair follicle matrix region property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/2d-ftu/skin-hair-follicle/v1.0/assets/2d-ftu-skin-hair-follicle.png" xsd:string {terms:licence="http://creativecommons.org/licenses/by/4.0/", xref="doi:10.48539/HBM853.HLFH.534"} property_value: RO:0002175 NCBITaxon:9606 property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2011-03-01T04:31:06Z [Term] id: CL:0002563 name: intestinal epithelial cell def: "An epithelial cell of the lining of the intestine." [GOC:tfm] subset: cellxgene_subset subset: human_subset subset: mouse_subset xref: ZFA:0009399 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0002251 ! epithelial cell of alimentary canal intersection_of: CL:0000066 ! epithelial cell intersection_of: BFO:0000050 UBERON:0001277 ! part of intestinal epithelium relationship: BFO:0000050 UBERON:0001277 ! part of intestinal epithelium property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2011-03-01T05:18:31Z [Term] id: CL:0002564 name: nucleus pulposus cell of intervertebral disc def: "A connective tissue cell of the nucleus pulposus cell of intervertebral disc." [GOC:tfm] subset: human_subset subset: mouse_subset is_a: CL:0002320 ! connective tissue cell intersection_of: CL:0002320 ! connective tissue cell intersection_of: BFO:0000050 UBERON:0002242 ! part of nucleus pulposus relationship: BFO:0000050 UBERON:0002242 ! part of nucleus pulposus property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2011-03-02T02:12:23Z [Term] id: CL:0002565 name: iris pigment epithelial cell def: "A pigment cell located in the epithelium of the iris." [GOC:tfm] subset: cellxgene_subset subset: eye_upper_slim subset: human_reference_atlas subset: human_subset subset: mouse_subset is_a: CL:0000066 ! epithelial cell is_a: CL:0000342 {is_inferred="true"} ! pigment cell (sensu Vertebrata) intersection_of: CL:0000342 ! pigment cell (sensu Vertebrata) intersection_of: BFO:0000050 UBERON:0002506 ! part of iris epithelium relationship: BFO:0000050 UBERON:0002506 ! part of iris epithelium property_value: RO:0002175 NCBITaxon:9606 property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2011-03-01T05:28:52Z [Term] id: CL:0002566 name: dark melanocyte def: "A melanocyte that appears darker due to content or amount of melanin granules." [GOC:tfm] subset: human_subset subset: mouse_subset synonym: "melanotic melanocyte" EXACT [PMID:10985850] synonym: "melanotic melanophore" EXACT [PMID:10985850] is_a: CL:0000148 ! melanocyte property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2011-03-01T05:57:11Z [Term] id: CL:0002567 name: light melanocyte def: "A melanocyte that appears lighter in color." [GOC:tfm] subset: human_subset subset: mouse_subset synonym: "amelanotic melanocyte" EXACT [PMID:10985850] synonym: "amelanotic melanophore" EXACT [PMID:10985850] is_a: CL:0000148 ! melanocyte property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2011-03-01T05:58:23Z [Term] id: CL:0002568 name: mesenchymal stem cell of Wharton's jelly def: "A mesenchymal stem cell that is part of Wharton's jelly." [GOC:tfm] subset: human_reference_atlas subset: human_subset subset: mouse_subset is_a: CL:0002569 ! mesenchymal stem cell of umbilical cord property_value: RO:0002175 NCBITaxon:9606 property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2011-03-01T09:51:18Z [Term] id: CL:0002569 name: mesenchymal stem cell of umbilical cord def: "A mesenchymal stem cell of the umbilical cord." [GOC:tfm] subset: human_subset subset: mouse_subset is_a: CL:0000134 ! mesenchymal stem cell is_a: CL:0000349 ! extraembryonic cell intersection_of: CL:0000134 ! mesenchymal stem cell intersection_of: BFO:0000050 UBERON:0003422 ! part of mesenchyme of umbilical cord relationship: BFO:0000050 UBERON:0003422 ! part of mesenchyme of umbilical cord property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2011-03-01T09:55:12Z [Term] id: CL:0002570 name: mesenchymal stem cell of adipose tissue def: "A mesenchymal stem cell of adipose tissue." [GOC:tfm] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "mesenchymal stem cell of adipose" EXACT [] is_a: CL:0000134 ! mesenchymal stem cell intersection_of: CL:0000134 ! mesenchymal stem cell intersection_of: BFO:0000050 UBERON:0001013 ! part of adipose tissue relationship: BFO:0000050 UBERON:0001013 ! part of adipose tissue property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0002570" xsd:string {name="mesenchymal stem cell of adipose tissue on CELLxGENE CellGuide"} property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 property_value: terms:description "Mesenchymal stem cells of adipose tissue, also known commonly as adipose-derived stem cells (ADSCs), are a population of adult stem cells that can be obtained easily from adipose tissues. They have many of the same regenerative properties as other mesenchymal stem cells, but are more easily accessible than bone marrow-derived stem cells.\nAdipose-derived stem cells show immense promise in the field of regenerative medicine due to their ability to differentiate into adipocytes, chondrocytes, myocytes, osteoblasts, and other cell types. ADSCs also possess immunomodulatory and homeostatic functions: they have the ability to suppress immune responses and provide a therapeutic environment for tissue repair and regeneration, as well as supporting the proliferation of adipocytes and the overall expansion of adipose tissue and contributing to the tissue's ability to react to demands of energy storage and mobilization. Dysfunction of these cells may contribute to metabolic complications observed in obesity and diabetes. \nADSCs have been used for therapeutic applications such as pathological wound healing, severe refractory acute graft-versus-host disease, and idiopathic thrombocytopenic purpura.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1016/j.biopha.2019.108765", xref="DOI:10.1016/j.tibtech.2006.01.010", xref="DOI:10.1038/s41536-019-0083-6", xref="DOI:10.1096/fj.202100332R", xref="DOI:10.1111/dgd.12049"} creation_date: 2011-03-01T09:57:17Z [Term] id: CL:0002571 name: hepatic mesenchymal stem cell def: "A mesenchymal stem cell of liver." [GOC:tfm] subset: human_subset subset: mouse_subset is_a: CL:0000134 {is_inferred="true"} ! mesenchymal stem cell is_a: CL:0002195 ! hepatic stem cell intersection_of: CL:0000134 ! mesenchymal stem cell intersection_of: BFO:0000050 UBERON:0002107 ! part of liver property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2011-03-01T09:58:51Z [Term] id: CL:0002572 name: vertebral mesenchymal stem cell def: "A mesenchymal stem cell of the vertebrae." [GOC:tfm] subset: human_subset subset: mouse_subset is_a: CL:0000134 {is_inferred="true"} ! mesenchymal stem cell is_a: CL:0001035 ! bone cell intersection_of: CL:0000134 ! mesenchymal stem cell intersection_of: BFO:0000050 UBERON:0002412 ! part of vertebra relationship: BFO:0000050 UBERON:0002412 ! part of vertebra property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2011-03-01T10:40:27Z [Term] id: CL:0002573 name: Schwann cell def: "A glial cell that myelinates or ensheathes axons in the peripheral nervous system." [GOC:tfm, PMID:16807057] comment: A myelinating Schwann cell wraps around a single axon. Myelination occurs in larger diameter axons, while a process called ensheathment occurs on smaller diameter axons in which a single cell wraps around multiple small, unmyelinated axons separating them with a thin layer of cytoplasm. The structure formed is called a Remak bundle. {xref="PMID:16807057"} subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "neurolemmocyte" EXACT [PMID:32119275, PMID:38638689] xref: BTO:0001220 xref: CALOHA:TS-0898 xref: MESH:D012583 is_a: CL:0000125 ! glial cell relationship: BFO:0000050 UBERON:0000010 ! part of peripheral nervous system property_value: RO:0002175 NCBITaxon:9606 property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0002573" xsd:string {name="Schwann cell on CELLxGENE CellGuide"} property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 property_value: terms:description "Schwann cells, also known as neurolemmocytes, are a type of glial cell located in the peripheral nervous system. These cells play a significant role in the healthy functioning of nerves by producing myelin, a fatty substance that forms a coating around nerve fibers. Myelin serves as an insulator and enhances the speed and efficiency of electrical nerve impulses; a single Schwann cell can myelinate a single axon. Myelination starts by the elongation and envelopment of the Schwann cell around the axon, followed by the synthesis and deposition of myelin layers. Some studies suggest that Schwann cells may regulate neuronal action potential, muscular contraction, and the sensitive response. \nWhile Schwann cells are most commonly known for the formation of the myelin sheath, some Schwann cells do not form myelin: Remak Schwann cells, a class of nonmyelinating Schwann cells, ensheath axons with smaller diameter, such as C fiber nociceptors in sciatic nerves and form Remak bundles.\nSchwann cells are found along both motor and sensory neurons and are crucial for the advancement and recovery of peripheral nerve injuries, due to their capacity to support nerve regeneration. In cases of nerve injury, Schwann cells play a vital role in recovery by initiating Wallerian degeneration, a process in which the part of the axon distal to the injury site degrades and is then cleared away. Following this, Schwann cells can guide the regrowth of the nerve, providing a conducive environment for axon regeneration. They remodel themselves into a regenerative phenotype, proliferate, and organize themselves into bands of Büngner that provide physical and chemical guidance for the regrowths of axons. This function of Schwann cells in the repair and regeneration of nervous system highlights their therapeutic potential in peripheral nerve injury treatments.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1002/glia.23892", xref="DOI:10.1016/B978-0-444-52902-2.00005-9", xref="DOI:10.1016/j.biocel.2006.05.007", xref="DOI:10.1186/1742-2094-8-110", xref="DOI:10.1186/s13064-020-00140-y"} creation_date: 2011-03-02T01:19:27Z [Term] id: CL:0002574 name: stromal cell of pancreas def: "A stromal cell of the pancreas." [GOC:tfm] subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset is_a: CL:0000499 {is_inferred="true"} ! stromal cell intersection_of: CL:0000499 ! stromal cell intersection_of: BFO:0000050 UBERON:0001264 ! part of pancreas relationship: BFO:0000050 UBERON:0001264 ! part of pancreas property_value: RO:0002175 NCBITaxon:9606 property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2011-03-02T02:40:41Z [Term] id: CL:0002575 name: central nervous system pericyte def: "A pericyte of the central nervous system." [GOC:tfm] subset: human_subset subset: mouse_subset is_a: CL:0000669 {is_inferred="true"} ! pericyte is_a: CL:0002319 ! neural cell intersection_of: CL:0000669 ! pericyte intersection_of: BFO:0000050 UBERON:0001017 ! part of central nervous system relationship: BFO:0000050 UBERON:0001017 ! part of central nervous system property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2011-03-02T02:54:18Z [Term] id: CL:0002576 name: perineurial cell def: "A glial cell that is part of the perineurium. This cell type has thin long bipolar cytoplasmic processes, pinocytotic vesicles, fragments of external lamina and/or external lamina-like material, attachment plaques, and desmosome-like junctions. Perineurial cells historically have been referred to as fibroblasts because of shape; however, unlike fibroblasts, a perineurial cell: does not have a compact nucleus and large endoplasmic reticulum; does have a double basement membrane opposed to a single basal lamina; is carefully joined to other perineurial cells by tight junctions into a single sheet as opposed to arranged in a large mass; and finally, can surround a small axon bundle at a nerve terminal whereas a fibroblast cannot." [GO:tfm, http://en.wikipedia.org/wiki/Perineurium, NCIT:C41442, PMID:25818566] comment: There are studies that largely accept the idea that the perineurial cell is a modified fibroblast with myofibroblastic features. {xref="PMID:36244793"} subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "perineurial glial cell" EXACT [PMID:25818566] is_a: CL:0000125 ! glial cell is_a: CL:0002320 ! connective tissue cell relationship: BFO:0000050 UBERON:0000121 ! part of perineurium property_value: RO:0002175 NCBITaxon:9606 property_value: terms:contributor https://orcid.org/0000-0001-7655-4833 property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2011-03-02T03:03:58Z [Term] id: CL:0002577 name: placental epithelial cell def: "An epithelial cell of the placenta." [GOC:tfm] subset: human_subset subset: mouse_subset is_a: CL:0000066 ! epithelial cell is_a: CL:0000349 {is_inferred="true"} ! extraembryonic cell intersection_of: CL:0000066 ! epithelial cell intersection_of: BFO:0000050 UBERON:0001987 ! part of placenta relationship: BFO:0000050 UBERON:0001987 ! part of placenta property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2011-03-02T03:21:30Z [Term] id: CL:0002578 name: mesenteric preadipocyte def: "A preadipocyte found in mesenteric tissue." [GOC:tfm] subset: human_subset subset: mouse_subset is_a: CL:0002334 {is_inferred="true"} ! preadipocyte intersection_of: CL:0002334 ! preadipocyte intersection_of: BFO:0000050 UBERON:0002095 ! part of mesentery relationship: BFO:0000050 UBERON:0002095 ! part of mesentery property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2011-03-03T04:19:40Z [Term] id: CL:0002579 name: omentum preadipocyte def: "A preadipocyte that is part of an omentum." [PMID:21484051] subset: human_subset subset: mouse_subset is_a: CL:0002334 {is_inferred="true"} ! preadipocyte intersection_of: CL:0002334 ! preadipocyte intersection_of: BFO:0000050 UBERON:0003688 ! part of omentum relationship: BFO:0000050 UBERON:0003688 ! part of omentum property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2011-03-03T04:19:42Z [Term] id: CL:0002580 name: preadipocyte of the breast def: "A preadipocyte that is part of the breast." [GOC:tfm] subset: human_subset subset: mouse_subset is_a: CL:0002334 {is_inferred="true"} ! preadipocyte is_a: CL:4006000 ! fibroblast of breast intersection_of: CL:0002334 ! preadipocyte intersection_of: BFO:0000050 UBERON:0000310 ! part of breast property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2011-03-03T04:19:46Z [Term] id: CL:0002581 name: perirenal preadipocyte def: "A preadipocyte that is part of a perirenal fat tissue." [PMID:20106964, PMID:31079959] subset: human_subset subset: mouse_subset is_a: CL:0002334 {is_inferred="true"} ! preadipocyte intersection_of: CL:0002334 ! preadipocyte intersection_of: BFO:0000050 UBERON:0005406 ! part of perirenal fat relationship: BFO:0000050 UBERON:0005406 ! part of perirenal fat property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2011-03-03T04:20:04Z [Term] id: CL:0002582 name: visceral preadipocyte def: "A preadipocyte that is part of visceral tissue." [GOC:tfm] subset: human_subset subset: mouse_subset is_a: CL:0002334 ! preadipocyte property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2011-03-03T04:32:56Z [Term] id: CL:0002583 name: subcutaneous preadipocyte def: "A preadipocyte that is part of subcutaneous tissue." [GOC:tfm] subset: human_subset subset: mouse_subset is_a: CL:0002334 {is_inferred="true"} ! preadipocyte intersection_of: CL:0002334 ! preadipocyte intersection_of: BFO:0000050 UBERON:0002072 ! part of hypodermis relationship: BFO:0000050 UBERON:0002072 ! part of hypodermis property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2011-03-03T04:33:01Z [Term] id: CL:0002584 name: renal cortical epithelial cell def: "An epithelial cell of the kidney cortex." [GOC:tfm] subset: human_subset subset: mouse_subset xref: KUPO:0001016 is_a: CL:0002518 {is_inferred="true"} ! kidney epithelial cell is_a: CL:0002681 {is_inferred="true"} ! kidney cortical cell intersection_of: CL:0002518 ! kidney epithelial cell intersection_of: BFO:0000050 UBERON:0001225 ! part of cortex of kidney [Term] id: CL:0002585 name: retinal blood vessel endothelial cell def: "A blood vessel endothelial cell that is part of the retina." [GOC:tfm] subset: cellxgene_subset subset: eye_upper_slim subset: human_reference_atlas subset: human_subset subset: mouse_subset is_a: CL:0000071 {is_inferred="true"} ! blood vessel endothelial cell is_a: CL:0009004 ! retinal cell intersection_of: CL:0000071 ! blood vessel endothelial cell intersection_of: BFO:0000050 UBERON:0000966 ! part of retina relationship: BFO:0000050 UBERON:0000966 ! part of retina property_value: RO:0002175 NCBITaxon:9606 property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0002585" xsd:string {name="retinal blood vessel endothelial cell on CELLxGENE CellGuide"} property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 property_value: terms:description "Retinal blood vessel endothelial cells constitute the innermost lining of the blood vessels found in the retina, the light-sensitive layer of tissue at the back of the eye. The primary role of these cells revolves around their location within the retinal vascular system, forming the structure of the blood-retinal barrier, a subset of the larger blood-ocular barrier system. \nThe endothelial cells are particularly involved in the growth of new retinal blood vessels from pre-existing ones (angiogenesis); this is critical in managing the amount of oxygen and essential nutrients delivered to the ocular tissues. They are crucial for maintaining homeostasis in the retinal environment by controlling the exchange of molecules between the blood and the retina. Furthermore, they mediate immune cell trafficking, supporting the immune privilege of the eye by preventing the unrestricted infiltration of inflammatory cells into the retina, thus maintaining ocular health and normal vision.\nThe malfunction or dysfunction of retinal blood vessel endothelial cells is implicated in numerous ocular pathologies, particularly diabetic retinopathy, which is one of the leading causes of blindness worldwide. In such conditions, the compromise in the integrity of the blood-retinal barrier and excess angiogenesis can lead to retinal edema and pathological neovascularization, resulting in vision loss.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:0.1016/j.preteyeres.2015.08.001", xref="DOI:10.1016/j.preteyeres.2012.08.004", xref="DOI:10.1038/nature04482", xref="DOI:10.5301/EJO.2010.6049"} creation_date: 2011-03-06T03:28:27Z [Term] id: CL:0002586 name: retinal pigment epithelial cell def: "An epithelial cell of the retinal pigmented epithelium." [GOC:tfm] subset: cellxgene_subset subset: eye_upper_slim subset: human_reference_atlas subset: human_subset subset: mouse_subset xref: BTO:0004910 xref: FMA:75802 is_a: CL:0000066 ! epithelial cell is_a: CL:0000149 ! visual pigment cell is_a: CL:0009004 ! retinal cell intersection_of: CL:0000066 ! epithelial cell intersection_of: BFO:0000050 UBERON:0001782 ! part of pigmented layer of retina relationship: BFO:0000050 UBERON:0001782 ! part of pigmented layer of retina relationship: BFO:0000051 GO:0042470 ! has part melanosome property_value: RO:0002175 NCBITaxon:9606 property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0002586" xsd:string {name="retinal pigment epithelial cell on CELLxGENE CellGuide"} property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 property_value: terms:description "Retinal pigment epithelial (RPE) cells form a single layer of cells at the back of the eye sandwiched between the neurosensory retina and the choroid, playing a significant role in maintaining vision health. These pigment-laden cells are highly specialized and perform an array of metabolic and transport functions essential for the maintenance of the photoreceptor cells (rods and cones) in the retina. The pigmentation of RPE cells actively aids in the absorption of excess light and the prevention of light scattering, thus enhancing the eye's optical properties.\nThe retinal pigment epithelium forms a key part of the blood/retina barrier. The cells have long sheet-like microvilli on their apical membrane that project into the light-sensitive outer segments of the photoreceptors, forming a close structural interaction. The basolateral membrane of the RPE interacts with the underlying Bruch’s membrane, which separates the RPE cells from fenestrated endothelium of the choriocapillaris. \nRPE cells support the photoreceptor by providing them with oxygen and nutrients (such as glucose, retinol and fatty acids) and removing waste products. They also recycle the visual pigment, in a process called the \"visual cycle\", where the RPE cells play a vital role in the regeneration of visual pigment (11-cis retinol) following the absorption of light. This is essential for the maintenance of photoreceptor excitability.\nBeyond this, RPE cells take part in the phagocytosis process, where they digest the shed ends of photoreceptor outer segments, thus, preventing the build-up of waste residue that could otherwise harm retinal health. They also secrete various factors, including growth factors required to maintain the structural integrity of choriocapillaris endothelium and photoreceptors, as well as immunosuppressive factors that play an important role in establishing the immune privilege of the eye.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1111/febs.16018", xref="DOI:10.1152/physrev.00021.2004", xref="DOI:10.3389/fphar.2021.727870/full", xref="https://www.sciencedirect.com/topics/chemistry/retinal-pigment"} creation_date: 2011-03-06T03:37:09Z [Term] id: CL:0002588 name: smooth muscle cell of the umbilical vein def: "A smooth muscle cell of the umbilical vein." [GOC:tfm] subset: human_subset subset: mouse_subset is_a: CL:0019018 ! blood vessel smooth muscle cell intersection_of: CL:0000359 ! vascular associated smooth muscle cell intersection_of: BFO:0000050 UBERON:0002066 ! part of umbilical vein relationship: BFO:0000050 UBERON:0002066 ! part of umbilical vein property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2011-03-06T05:00:51Z [Term] id: CL:0002589 name: smooth muscle cell of the brachiocephalic vasculature def: "A smooth muscle cell of the bachiocephalic vasculature." [GOC:tfm] subset: human_subset subset: mouse_subset is_a: CL:0019018 ! blood vessel smooth muscle cell intersection_of: CL:0000359 ! vascular associated smooth muscle cell intersection_of: BFO:0000050 UBERON:0001529 ! part of brachiocephalic artery relationship: BFO:0000050 UBERON:0001529 ! part of brachiocephalic artery property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2011-03-06T05:00:58Z [Term] id: CL:0002590 name: smooth muscle cell of the brain vasculature def: "A vascular associated smooth muscle cell of the brain vasculature." [GOC:tfm] subset: cellxgene_subset subset: human_subset subset: mouse_subset is_a: CL:0000359 {is_inferred="true"} ! vascular associated smooth muscle cell is_a: CL:0002319 ! neural cell intersection_of: CL:0000359 ! vascular associated smooth muscle cell intersection_of: BFO:0000050 UBERON:0000955 ! part of brain relationship: BFO:0000050 UBERON:0000955 ! part of brain property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2011-03-06T05:01:20Z [Term] id: CL:0002591 name: smooth muscle cell of the pulmonary artery def: "A smooth muscle of the pulmonary artery." [GOC:tfm] subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset xref: BTO:0003336 is_a: CL:0019018 ! blood vessel smooth muscle cell intersection_of: CL:0000359 ! vascular associated smooth muscle cell intersection_of: BFO:0000050 UBERON:0002012 ! part of pulmonary artery relationship: BFO:0000050 UBERON:0002012 ! part of pulmonary artery property_value: RO:0002175 NCBITaxon:9606 property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0002591" xsd:string {name="smooth muscle cell of the pulmonary artery on CELLxGENE CellGuide"} property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 property_value: terms:description "Smooth muscle cells of the pulmonary artery form a principal component of the pulmonary artery's media layer, the middle section of the artery wall typically found between endothelial inner layer (intima) and the outermost connective tissue layer (adventitia). The unique structure of these cells, defined by fusiform shape and the absence of striations, sets them apart from other muscle cell types, including cardiac and skeletal.\nThe primary function of smooth muscle cells of the pulmonary artery is to regulate the diameter of the pulmonary artery, which in turn controls the flow of blood into the lungs. They accomplish this task through the contraction and relaxation, indicative of vasoconstriction and vasodilation respectively. When these cells contract, the diameter of the artery narrows, leading to reduced blood flow. Conversely, relaxation of these cells widens the artery, facilitating increased blood flow. Such blood flow modulation is crucial for the maintenance of blood pressure and ensuring that the lungs receive an adequate blood supply for efficient oxygen exchange.\nAs a result, abnormal function or proliferation of these cells can contribute to conditions such as pulmonary hypertension, a condition characterized by high blood pressure in the arteries leading to the lungs. This can occur due to hypoxia (lack of enough oxygen), leading to excessive constriction or proliferation of the smooth muscle cells.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1016/j.apsb.2012.12.007", xref="DOI:10.1124/pr.115.010652", xref="https://www.sciencedirect.com/topics/medicine-and-dentistry/pulmonary-artery-smooth-muscle-cell"} creation_date: 2011-03-06T05:01:28Z [Term] id: CL:0002592 name: smooth muscle cell of the coronary artery def: "A smooth muscle cell of the coronary artery." [GOC:tfm] subset: human_reference_atlas subset: human_subset subset: mouse_subset is_a: CL:0002494 ! cardiocyte is_a: CL:0019018 ! blood vessel smooth muscle cell intersection_of: CL:0000359 ! vascular associated smooth muscle cell intersection_of: BFO:0000050 UBERON:0001621 ! part of coronary artery relationship: BFO:0000050 UBERON:0001621 ! part of coronary artery property_value: RO:0002175 NCBITaxon:9606 property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2011-03-06T05:01:34Z [Term] id: CL:0002593 name: smooth muscle cell of the internal thoracic artery def: "A smooth muscle of the internal thoracic artery." [GOC:tfm] subset: human_subset subset: mouse_subset is_a: CL:0002595 ! smooth muscle cell of the subclavian artery intersection_of: CL:0000359 ! vascular associated smooth muscle cell intersection_of: BFO:0000050 UBERON:0002456 ! part of internal thoracic artery relationship: BFO:0000050 UBERON:0002456 ! part of internal thoracic artery property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2011-03-06T05:01:41Z [Term] id: CL:0002594 name: smooth muscle cell of the umbilical artery def: "A smooth muscle cell of the umbilical artery." [GOC:tfm] subset: human_subset subset: mouse_subset is_a: CL:0019018 ! blood vessel smooth muscle cell intersection_of: CL:0000359 ! vascular associated smooth muscle cell intersection_of: BFO:0000050 UBERON:0001310 ! part of umbilical artery relationship: BFO:0000050 UBERON:0001310 ! part of umbilical artery property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2011-03-06T05:01:48Z [Term] id: CL:0002595 name: smooth muscle cell of the subclavian artery def: "A smooth muscle cell of the subclavian artery." [GOC:tfm] subset: human_subset subset: mouse_subset is_a: CL:0019018 ! blood vessel smooth muscle cell intersection_of: CL:0000359 ! vascular associated smooth muscle cell intersection_of: BFO:0000050 UBERON:0001533 ! part of subclavian artery relationship: BFO:0000050 UBERON:0001533 ! part of subclavian artery property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2011-03-06T05:01:52Z [Term] id: CL:0002596 name: smooth muscle cell of the carotid artery def: "Smooth muscle cell of the carotid artery." [GOC:tfm] subset: human_subset subset: mouse_subset is_a: CL:0019018 ! blood vessel smooth muscle cell intersection_of: CL:0000359 ! vascular associated smooth muscle cell intersection_of: BFO:0000050 UBERON:0005396 ! part of carotid artery segment relationship: BFO:0000050 UBERON:0005396 ! part of carotid artery segment property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2011-03-06T05:01:56Z [Term] id: CL:0002597 name: smooth muscle cell of bladder def: "A smooth muscle cell of the bladder." [GC:tfm] subset: human_reference_atlas subset: human_subset subset: mouse_subset xref: KUPO:0001122 is_a: CL:0000192 {is_inferred="true"} ! smooth muscle cell is_a: CL:1001319 ! bladder cell intersection_of: CL:0000192 ! smooth muscle cell intersection_of: BFO:0000050 UBERON:0001255 ! part of urinary bladder property_value: RO:0002175 NCBITaxon:9606 property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2011-03-06T05:43:24Z [Term] id: CL:0002598 name: bronchial smooth muscle cell def: "Any smooth muscle cell that is part of some bronchus." [FBC:Autogenerated] subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset xref: BTO:0004402 is_a: CL:0019019 ! tracheobronchial smooth muscle cell intersection_of: CL:0000192 ! smooth muscle cell intersection_of: BFO:0000050 UBERON:0002185 ! part of bronchus relationship: BFO:0000050 UBERON:0002185 ! part of bronchus property_value: RO:0002175 NCBITaxon:9606 property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0002598" xsd:string {name="bronchial smooth muscle cell on CELLxGENE CellGuide"} property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 property_value: terms:description "Bronchial smooth muscle cells are specialized types of cells found in the bronchi of the respiratory system in mammals. These bronchi are tubular structures that function to carry air from the trachea into the lungs. As part of the smooth muscle tissue, bronchial smooth muscle cells are involuntary cells, meaning they function with minimal direct voluntary control. They are characterized by their elongated spindle-shaped structure, with each cell containing a single central nucleus.\nThe primary function of bronchial smooth muscle cells is to control airway diameter, which directly influences the flow of air into and out of the lungs. Muscular contractions and relaxations mediated by these cells enable the bronchi to constrict or expand, facilitating the regulation of respiratory airflow. Additionally, these cells play a pivotal role in immune responses as they produce and release various substances that can instigate or lessen inflammation of airway tissue. Furthermore, bronchial smooth muscle cells can proliferate and lay down collagen and other extracellular matrix proteins, contributing to the structural integrity of the bronchial tubes.\nIn pathological conditions, such as asthma and chronic obstructive pulmonary disease, the function and biology of bronchial smooth muscle cells change. Asthma, for example, is associated with an abnormal increase in the mass of the bronchial smooth muscles, leading to narrowing of the airways and resultant breathing difficulties. These cells also exhibit altered contractile behavior and an augmented immune response during inflammatory lung diseases.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1152/japplphysiol.00313.2006", xref="DOI:10.1183/09031936.00019810", xref="https://www.ncbi.nlm.nih.gov/books/NBK537353/", xref="https://www.sciencedirect.com/topics/agricultural-and-biological-sciences/bronchial-muscle"} creation_date: 2011-03-06T05:46:39Z [Term] id: CL:0002599 name: smooth muscle cell of the esophagus def: "A smooth muscle cell of the esophagus." [GOC:tfm] subset: human_subset subset: mouse_subset is_a: CL:0000192 {is_inferred="true"} ! smooth muscle cell intersection_of: CL:0000192 ! smooth muscle cell intersection_of: BFO:0000050 UBERON:0001043 ! part of esophagus relationship: BFO:0000050 UBERON:0001043 ! part of esophagus property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2011-03-06T05:48:17Z [Term] id: CL:0002600 name: smooth muscle cell of trachea def: "A smooth muscle cell of the trachea." [GOC:tfm] subset: cellxgene_subset subset: human_subset subset: mouse_subset is_a: CL:0019019 ! tracheobronchial smooth muscle cell intersection_of: CL:0000192 ! smooth muscle cell intersection_of: BFO:0000050 UBERON:0003126 ! part of trachea relationship: BFO:0000050 UBERON:0003126 ! part of trachea property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0002600" xsd:string {name="smooth muscle cell of trachea on CELLxGENE CellGuide"} property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 property_value: terms:description "Smooth muscle cells of the trachea have a characteristic 'smooth' (non-striated) appearance under the microscope, a distinguishing feature that differentiates them from skeletal and cardiac muscle cells. The smooth appearance is due to the organization of actin and myosin filaments in the cell, which allows for a controlled, contractile function.\nThese cells play a key role in controlling the diameter of the trachea, thus regulating the airflow. They are responsible for the involuntary constriction and relaxation of the trachea influencing the air passage during various physiological behaviors like breathing, coughing, and sneezing. This autonomic control allows for adaptations to specific body requirements without conscious control, such as increasing air flow during exercise or restricting it during rest.\nIn conditions such as asthma, chronic bronchitis, and emphysema, there are changes in smooth muscle cells. For example, the mass of smooth muscle cells increases in chronic airway diseases, possibly in response to chronic inflammation. This increase may indicate a pathological condition or be a part of the body's response to injury and repair.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1016/s1357-2725(02)00259-5", xref="https://www.ncbi.nlm.nih.gov/books/NBK9961", xref="https://www.sciencedirect.com/topics/agricultural-and-biological-sciences/airway-smooth-muscle"} creation_date: 2011-03-06T05:50:28Z [Term] id: CL:0002601 name: uterine smooth muscle cell def: "A smooth muscle cell of the uterus." [GOC:tfm] subset: cellxgene_subset subset: human_subset subset: mouse_subset is_a: CL:0000192 {is_inferred="true"} ! smooth muscle cell intersection_of: CL:0000192 ! smooth muscle cell intersection_of: BFO:0000050 UBERON:0000995 ! part of uterus relationship: BFO:0000050 UBERON:0000995 ! part of uterus property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0002601" xsd:string {name="uterine smooth muscle cell on CELLxGENE CellGuide"} property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 property_value: terms:description "Uterine smooth muscle cells are specialized cells that make up the majority of the uterus and in particular, the myometrium. The myometrium is a thick, involuntary muscle layer, principally consisting of verticillate cell bundles that sculpt the helical architecture of the uterus. This dense muscular tissue, packed with uterine smooth muscle cells, is responsible for the significant contractile force witnessed during the physical processes of labor and childbirth.\nIn the non-pregnant uterus, they exist in a quiescent phase. Upon implantation, these cells are primarily responsible for the expansion consequently allowing the uterus to accommodate the growing fetus. Towards the end of pregnancy, under the influence of hormonal and mechanical signals, uterine smooth muscle cells transition from a relaxed phase to an active contractile phase, culminating in the delivery of the fetus.\nAt the cellular level, these transitions involve significant changes in the electrophysiological properties of uterine smooth muscle cells. Governed by a complex interplay of ion channels, transporters, and signaling proteins, these cells adjust their electrical activity, conduction properties, and contracting mechanisms. Any issues with these processes can result in problems such as preterm birth or labor dysfunction.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1177/0036850419850431", xref="DOI:10.1203/00006450-199811000-00001", xref="DOI:10.3791/56639", xref="https://www.ncbi.nlm.nih.gov/books/NBK532927/"} creation_date: 2011-03-06T05:53:28Z [Term] id: CL:0002602 name: annulus pulposus cell def: "Any connective tissue cell that is part of some annulus fibrosus disci intervertebralis." [FBC:Autogenerated] subset: human_subset subset: mouse_subset synonym: "anulus pulposus cell" EXACT [] is_a: CL:0002320 {is_inferred="true"} ! connective tissue cell intersection_of: CL:0002320 ! connective tissue cell intersection_of: BFO:0000050 UBERON:0004715 ! part of annulus fibrosus disci intervertebralis relationship: BFO:0000050 UBERON:0004715 ! part of annulus fibrosus disci intervertebralis property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2011-03-06T06:50:53Z [Term] id: CL:0002603 name: astrocyte of the cerebellum def: "An astrocyte of the cerebellum." [GOC:tfm] subset: cellxgene_subset subset: human_subset subset: mouse_subset is_a: CL:0000127 {is_inferred="true"} ! astrocyte is_a: CL:2000005 ! brain macroglial cell intersection_of: CL:0000127 ! astrocyte intersection_of: BFO:0000050 UBERON:0002037 ! part of cerebellum relationship: BFO:0000050 UBERON:0002037 ! part of cerebellum property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0002603" xsd:string {name="astrocyte of the cerebellum on CELLxGENE CellGuide"} property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 property_value: terms:description "Astrocytes of the cerebellum, also known as cerebellar astrocytes, constitute a major subtype of glial cells in the cerebellum, an integral region of the brain responsible for regulating motor movements and cognitive processes. These astrocytes are unique to the cerebellum, differing in morphological and functional characteristics from astrocytess located in other parts of the nervous system. They play a crucial role in managing the brain's complex microenvironment by maintaining neuronal health, supporting biochemical pathways, and contributing to targeted neural communication.\nAstrocytes of the cerebellum operate through an interactive network with neurons, blood vessels, and other glial cells. They provide physical and nutritional support for neurons, helping preserve neuronal survival and function. These cells effectively manage the extracellular ion and neurotransmitter balance, pivotal for synaptic transmission. They also contribute to the maintenance of the blood-brain barrier, a semi-permeable membrane that safeguards the brain from harmful substances in the bloodstream, ensuring cerebral homeostasis.\nFurthermore, cerebellar astrocytes are involved in the processing and modulation of synapses, the junctions where neurons exchange information. They regulate the release and uptake of neurotransmitters, which helps in synaptic plasticity, a process that is integral in learning and memory. Moreover, these astrocytes produce and secrete various neurotrophic factors, including brain-derived neurotrophic factor (BDNF), which is crucial for neurogenesis and synaptic plasticity. Therefore, astrocytes of the cerebellum not only execute supportive roles but are also actively involved in modifying neuronal function and enabling neuroplasticity.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1007/s12311-019-01046-0", xref="DOI:10.1016/j.brainres.2006.06.008", xref="DOI:10.1016/j.pneurobio.2013.08.001", xref="DOI:10.1038/nrn1824", xref="DOI:10.1155/2014/232105"} creation_date: 2011-03-06T06:57:27Z [Term] id: CL:0002604 name: hippocampal astrocyte def: "An astrocyte that is part of the hippocampus." [https://orcid.org/0000-0001-7258-9596] subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "astrocyte of the hippocampal formation" EXACT [] synonym: "astrocyte of the hippocampus" EXACT [] is_a: CL:0002605 ! astrocyte of the cerebral cortex is_a: CL:1001580 ! hippocampal glial cell intersection_of: CL:0000127 ! astrocyte intersection_of: BFO:0000050 UBERON:0002421 ! part of hippocampal formation property_value: RO:0002175 NCBITaxon:9606 property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2011-03-06T06:57:33Z [Term] id: CL:0002605 name: astrocyte of the cerebral cortex def: "A transcriptomically distinct astrocyte that is found in the cerebral cortex." [GOC:tfm] subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset is_a: CL:0012000 ! astrocyte of the forebrain is_a: CL:1001579 ! cerebral cortex glial cell intersection_of: CL:0000127 ! astrocyte intersection_of: BFO:0000050 UBERON:0000956 ! part of cerebral cortex property_value: RO:0002175 NCBITaxon:9606 property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2011-03-06T06:57:36Z [Term] id: CL:0002606 name: astrocyte of the spinal cord def: "An astrocyte of the spinal cord." [GOC:tfm] subset: human_subset subset: mouse_subset is_a: CL:0000127 {is_inferred="true"} ! astrocyte intersection_of: CL:0000127 ! astrocyte intersection_of: BFO:0000050 UBERON:0002240 ! part of spinal cord relationship: BFO:0000050 UBERON:0002240 ! part of spinal cord property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2011-03-06T07:11:26Z [Term] id: CL:0002607 name: migratory enteric neural crest cell def: "A neural crest cell that gives rise to cells of the enteric nervous system." [GOC:tfm] subset: cellxgene_subset subset: human_subset subset: mouse_subset is_a: CL:0000333 ! migratory neural crest cell property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2011-03-06T07:24:35Z [Term] id: CL:0002608 name: hippocampal neuron def: "A neuron with a soma found in the hippocampus." [GOC:tfm] subset: cellxgene_subset subset: human_subset subset: mouse_subset is_a: BFO:0000002 is_a: CL:0010012 ! cerebral cortex neuron intersection_of: CL:0000540 ! neuron intersection_of: RO:0002100 UBERON:0002421 ! has soma location hippocampal formation relationship: RO:0002100 UBERON:0002421 ! has soma location hippocampal formation property_value: skos:prefLabel "hippocampal neuron" xsd:string property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2011-03-06T07:31:49Z [Term] id: CL:0002610 name: raphe nuclei neuron def: "A neuron of the raphe nuclei." [GOC:tfm] subset: human_subset subset: mouse_subset is_a: BFO:0000002 is_a: CL:2000029 ! central nervous system neuron intersection_of: CL:0000540 ! neuron intersection_of: RO:0002100 UBERON:0004684 ! has soma location raphe nuclei relationship: RO:0002100 UBERON:0004684 ! has soma location raphe nuclei property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2011-03-06T07:42:06Z [Term] id: CL:0002611 name: neuron of the dorsal spinal cord def: "A CNS neuron of the dorsal spinal cord." [GOC:tfm] subset: human_subset subset: mouse_subset is_a: CL:2000029 ! central nervous system neuron intersection_of: CL:0000540 ! neuron intersection_of: RO:0002100 UBERON:0002256 ! has soma location dorsal horn of spinal cord relationship: RO:0002100 UBERON:0002256 ! has soma location dorsal horn of spinal cord property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2011-03-06T07:43:34Z [Term] id: CL:0002612 name: neuron of the ventral spinal cord def: "A neuron of the ventral spinal cord." [GOC:tfm] subset: human_subset subset: mouse_subset is_a: CL:2000029 ! central nervous system neuron intersection_of: CL:0000540 ! neuron intersection_of: RO:0002100 UBERON:0002257 ! has soma location ventral horn of spinal cord relationship: RO:0002100 UBERON:0002257 ! has soma location ventral horn of spinal cord property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2011-03-06T07:46:03Z [Term] id: CL:0002613 name: striatum neuron def: "A neuron of the striatum." [GOC:tfm] subset: human_subset subset: mouse_subset is_a: CL:0012001 ! neuron of the forebrain intersection_of: CL:0000540 ! neuron intersection_of: RO:0002100 UBERON:0002435 ! has soma location striatum relationship: RO:0002100 UBERON:0002435 ! has soma location striatum property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2011-03-06T07:47:12Z [Term] id: CL:0002614 name: neuron of the substantia nigra def: "A neuron of the substantia nigra." [GOC:tfm] subset: human_subset subset: mouse_subset is_a: CL:2000029 ! central nervous system neuron intersection_of: CL:0000540 ! neuron intersection_of: RO:0002100 UBERON:0002038 ! has soma location substantia nigra relationship: RO:0002100 UBERON:0002038 ! has soma location substantia nigra property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2011-03-06T07:48:42Z [Term] id: CL:0002615 name: adipocyte of omentum tissue def: "An adipocyte that is part of omentum tissue." [GOC:tfm] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "omental adipocyte" EXACT [] synonym: "omental fat cell" EXACT [] is_a: CL:0000136 {is_inferred="true"} ! adipocyte intersection_of: CL:0000136 ! adipocyte intersection_of: BFO:0000050 UBERON:0003688 ! part of omentum relationship: BFO:0000050 UBERON:0003688 ! part of omentum property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2011-03-14T10:17:00Z [Term] id: CL:0002616 name: perirenal adipocyte def: "An adipocyte of perirenal fat tissue." [GOC:tfm] subset: human_subset subset: mouse_subset synonym: "perirenal adipocyte cell" EXACT [] synonym: "perirenal fat cell" EXACT [] is_a: CL:0000136 {is_inferred="true"} ! adipocyte intersection_of: CL:0000136 ! adipocyte intersection_of: BFO:0000050 UBERON:0005406 ! part of perirenal fat relationship: BFO:0000050 UBERON:0005406 ! part of perirenal fat property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2011-03-14T10:17:05Z [Term] id: CL:0002617 name: adipocyte of breast def: "An adipocyte that is part of the breast." [GOC:tfm] comment: Adipocytes found in the subcutaneous adipose tissue of breast. The breast consists of three main components, the skin, the subcutaneous adipose tissue and the functional glandular tissue that comprises both parenchyma and stroma.[CALOHA] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "breast adipocyte" EXACT [] synonym: "fat cell of breast" EXACT [] xref: CALOHA:TS-2377 is_a: CL:0000136 {is_inferred="true"} ! adipocyte intersection_of: CL:0000136 ! adipocyte intersection_of: BFO:0000050 UBERON:0000310 ! part of breast relationship: BFO:0000050 UBERON:0000310 ! part of breast property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0002617" xsd:string {name="adipocyte of breast on CELLxGENE CellGuide"} property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 property_value: terms:description "Adipocytes of the breast, commonly known as breast fat cells, serve crucial structural, protective, and metabolic roles. These specialized cells, ubiquitously found within the breast's adipose tissue, primarily contribute to the organ's overall shape and cushioning, providing physical support to surrounding structures. \nAdipocytes are highly active metabolically and play a key role in lipid homeostasis, acting as principal sites for energy storage and release. These cells store excess energy in the form of triglycerides during times of energy surplus, releasing it during periods of energy deficit as free fatty acids and glycerol into the bloodstream. Therefore, regulation of breast adipocytes' size and number is critical to maintain overall energy balance. Moreover, during lactation, these fat cells assist in providing lipid molecules necessary for the production of breast milk.\nMoreover, breast adipocytes notably function in the endocrine system, secreting a wide array of hormones, growth factors, and cytokines, collectively referred to as adipokines. While adipokines have a wide range of effects, some are believed to exert crucial influence on breast cancer physiology. Indeed, excessive adipose tissue, leading to a state of chronic low-grade inflammation, is associated with an increased risk of several types of cancer, including breast cancer.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1007/s11154-021-09633-5", xref="DOI:10.1016/j.phrs.2020.104741", xref="DOI:10.1038/s41467-018-05911-0", xref="DOI:10.1038/s41523-017-0015-9", xref="DOI:10.3390/ijms21165760"} creation_date: 2011-03-14T10:17:07Z [Term] id: CL:0002618 name: endothelial cell of umbilical vein def: "An endothelial cell of the umbilical vein." [GOC:tfm] subset: human_subset subset: mouse_subset xref: BTO:0004296 is_a: CL:0002543 ! vein endothelial cell intersection_of: CL:0000115 ! endothelial cell intersection_of: BFO:0000050 UBERON:0002066 ! part of umbilical vein relationship: BFO:0000050 UBERON:0002066 ! part of umbilical vein property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0002618" xsd:string {name="endothelial cell of umbilical vein on CELLxGENE CellGuide"} property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 property_value: terms:description "Endothelial cells of the umbilical vein form the inner lining of the veins found in the umbilical cord. They are involved in tube formation and migration which are essential for angiogenesis, the process of generating new blood vessels; this is critical during the fetal stage for the development of the circulatory system. Endothelial cells of the umbilical vein also play a role in controlling the passage of white blood cells into tissues during inflammatory responses.\nBecause human umbilical vein endothelial cells (HUVECs) can easily be derived from the umbilical cord, and because they express common endothelial cell markers, they have been used as an epithelial cell model for studies on cell proliferation, migration, angiogenesis, and inflammation. They have been used as models for vascular diseases like atherosclerosis, for investigating how tumor cells infiltrate blood vessels and form metastases. \nThus, while endothelial cells of the umbilical vein play a critical role in vascular biology, they also represent a powerful tool in disease studies and potential treatment strategies.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1002/cyto.a.20952", xref="DOI:10.1007/s12015-006-0015-x", xref="DOI:10.1172/JCI107470", xref="DOI:10.3390/app10030938", xref="https://www.ncbi.nlm.nih.gov/books/NBK53254/"} creation_date: 2011-03-14T11:36:51Z [Term] id: CL:0002619 name: adult endothelial progenitor cell def: "An adult angioblastic cell released from the bone marrow, or from the kidney in some teleost species, capable of blood circulation and participation in angiogenesis by differentiating into blood vessel endothelial cells." [GOC:tfm, PMID:20807818, PMID:9020076, WikipediaVersioned:Endothelial_progenitor_cell&oldid=1069930016] comment: The existence of adult endothelial progenitor cells has been controversial in the past. subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "EPC" EXACT [] is_a: CL:0000566 ! angioblastic mesenchymal cell property_value: RO:0002175 NCBITaxon:9606 property_value: seeAlso "https://github.com/obophenotype/cell-ontology/issues/1410" xsd:string property_value: seeAlso "https://github.com/obophenotype/cell-ontology/issues/348" xsd:string property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2011-03-14T12:11:18Z [Term] id: CL:0002620 name: skin fibroblast def: "A fibroblast of skin." [GOC:tfm] subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset xref: BTO:0001255 xref: CALOHA:TS-0935 is_a: CL:0000057 {is_inferred="true"} ! fibroblast intersection_of: CL:0000057 ! fibroblast intersection_of: BFO:0000050 UBERON:0002097 ! part of skin of body relationship: BFO:0000050 UBERON:0002097 ! part of skin of body property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/2d-ftu/skin-dermal-papilla/v1.1/assets/2d-ftu-skin-dermal-papilla.png" xsd:string {terms:licence="http://creativecommons.org/licenses/by/4.0/", xref="doi:10.48539/HBM476.JQZD.394"} property_value: RO:0002175 NCBITaxon:9606 property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0002620" xsd:string {name="skin fibroblast on CELLxGENE CellGuide"} property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 property_value: terms:description "Skin fibroblasts specialized cells found in the dermis, the middle layer of the skin, where they play critical roles in maintaining skin health and functionality. Characterized by an elongated, spindle-like shape, skin fibroblasts are the principal active cells in the connective tissue of the skin. The primary function of skin fibroblasts is the maintenance and regeneration of the extracellular matrix, which provides structural and nutritional support for other skin cells, particularly keratinocytes and epithelial cells. These cells contribute to the production of collagen, elastin, and glycosaminoglycans - key proteins that maintain the elasticity, strength, and resilience of the skin. Through this function, skin fibroblasts help prevent skin aging and maintain tissue integrity, contributing to the skin's overall health and appearance.\nIn addition, skin fibroblasts are implicated in the skin's wound healing process. Following injury, fibroblasts migrate to the wound site where they start proliferating and laying down new connective tissue. They play a vital role in the repair, regeneration, and healing of the skin; in the final stages of wound healing, skin fibroblasts help contract the healing tissue to minimize scar formation. Furthermore, recent research highlights their role in the immune response, with some studies indicating that skin fibroblasts can react to, and have a role in dealing with, pathogen invasion.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1016/j.cell.2021.06.024", xref="DOI:10.1016/j.stem.2022.07.006", xref="DOI:10.2217/rme-2018-0073", xref="DOI:10.3389/fimmu.2020.00648"} creation_date: 2011-03-14T12:31:49Z [Term] id: CL:0002621 name: gingival epithelial cell def: "Any stratified squamous epithelial cell that is part of some gingival epithelium." [FBC:Autogenerated] subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset is_a: CL:0000240 ! stratified squamous epithelial cell is_a: CL:1001576 ! oral mucosa squamous cell intersection_of: CL:0000240 ! stratified squamous epithelial cell intersection_of: BFO:0000050 UBERON:0001949 ! part of gingival epithelium relationship: BFO:0000050 UBERON:0001949 ! part of gingival epithelium property_value: RO:0002175 NCBITaxon:9606 property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2011-03-14T12:46:28Z [Term] id: CL:0002622 name: prostate stromal cell def: "A stromal cell of the prostate." [GOC:tfm] subset: cellxgene_subset subset: human_subset subset: mouse_subset xref: BTO:0003972 is_a: CL:0000499 {is_inferred="true"} ! stromal cell intersection_of: CL:0000499 ! stromal cell intersection_of: BFO:0000050 UBERON:0002367 ! part of prostate gland relationship: BFO:0000050 UBERON:0002367 ! part of prostate gland property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2011-03-14T02:11:10Z [Term] id: CL:0002623 name: acinar cell of salivary gland def: "An acinar cell that is part of the salivary gland epithelium, responsible for synthesizing and secreting the primary saliva essential for oral digestion, antimicrobial defense, and mucosal immunity. It features apical-basal polarity with apical secretory granules, and tight junctions that maintain polarity and regulate calcium-dependent saliva exocytosis triggered by parasympathetic and sympathetic signals (Ambudkar, 2015). This cell functions in coordination with contractile myoepithelial cells, which aid saliva flow through the ducts into the oral cavity (Khan et al., 2022). In mice and humans, acinar cell development relies on the transcription factor SOX2 (Emmerson et al., 2017), with self-renewal achieved primarily through acinar cell self-duplication and supported by progenitor populations during injury and regeneration (Aure et al., 2016)." [GOC:tfm, PMID:24646566, PMID:25843887, PMID:28623666, PMID:34989394, PMID:35343828] subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "salivary acinar cell" EXACT [PMID:24646566] synonym: "salivary gland acinar cell" EXACT [PMID:24646566] is_a: CL:0000622 {is_inferred="true"} ! acinar cell is_a: CL:1001596 ! salivary gland glandular cell intersection_of: CL:0000622 ! acinar cell intersection_of: BFO:0000050 UBERON:0004809 ! part of salivary gland epithelium relationship: BFO:0000051 GO:0030141 ! has part secretory granule relationship: RO:0002215 GO:0017156 ! capable of calcium-ion regulated exocytosis relationship: RO:0002215 GO:0045087 ! capable of innate immune response relationship: RO:0002215 GO:0046541 ! capable of saliva secretion property_value: RO:0002175 NCBITaxon:9606 property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0002623" xsd:string {name="acinar cell of salivary gland on CELLxGENE CellGuide"} property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 property_value: terms:description "Acinar cells of the salivary gland are a critical part of the oral physiology and the digestive mechanism. These specialized cells are concentrated towards the terminal ends of the salivary glands, where they form sac-like acini or clusters. The primary function of these cells is to produce and secrete saliva. This substance, comprised mainly of water, electrolytes, mucins, and enzymes, is vital for the initial stages of digestion and for the regular maintenance of oral health. \nAcinar cells produce the two main types of saliva: serous and mucinous. Serous saliva contains the enzyme amylase responsible for the initial breakdown of complex carbohydrates and is predominantly produced by the parotid gland, the largest of salivary glands. The mucinous type, more common in the submandibular and sublingual glands, contains mucin that aids in lubrication, facilitating the process of mastication and bolus formation.\nMoreover, acinar cells also express and respond to various endocrine, paracrine, and autocrine hormones that govern the quantity and composition of the saliva produced. This implies sensitivity and modulation according to the internal and external environment, dietary habits, and even circadian rhythms. \nImpairment of acinar cells, whether due to damage or related to a systemic condition such as Sjögren's Syndrome, can disrupt the optimal functioning of the oral and digestive systems. In conclusion, acinar cells of the salivary gland have a substantial role in oral health and overall homeostasis.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1016/S0140-6736(05)66990-5", xref="DOI:10.1038/sj.bdj.4807861", xref="DOI:10.1111/prd.12116", xref="DOI:10.1152/physrev.00011.2011", xref="https://www.ncbi.nlm.nih.gov/books/NBK538325/"} creation_date: 2011-03-14T02:22:22Z [Term] id: CL:0002624 name: paneth cell of the appendix def: "A paneth cell of the appendix." [GOC:tfm] subset: human_subset subset: mouse_subset is_a: CL:0000510 {is_inferred="true"} ! paneth cell is_a: CL:1001585 ! appendix glandular cell intersection_of: CL:0000510 ! paneth cell intersection_of: BFO:0000050 UBERON:0001154 ! part of vermiform appendix property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2011-03-15T09:38:18Z [Term] id: CL:0002625 name: seminiferous tubule epithelial cell def: "A cell of the seminiferous tubule epithelium." [GOC:tfm] subset: human_subset subset: mouse_subset is_a: CL:0000068 ! duct epithelial cell is_a: CL:0000077 {is_inferred="true"} ! mesothelial cell intersection_of: CL:0000066 ! epithelial cell intersection_of: BFO:0000050 UBERON:0001343 ! part of seminiferous tubule of testis relationship: BFO:0000050 UBERON:0004813 ! part of seminiferous tubule epithelium property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2011-03-15T11:59:23Z [Term] id: CL:0002626 name: immature astrocyte def: "An immature astrocyte." [GOC:dsd] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "immature astrocytic glia" EXACT [] is_a: CL:0000127 ! astrocyte [Term] id: CL:0002627 name: mature astrocyte def: "A mature astrocyte that is capable of producing cytokines." [GOC:dsd, PMID:12898703, PMID:8734446] comment: Mature astrocytes are reportedly able to produce aspartate, ATP, BDNF, BMP-2a, BMP-3, CCL2, CCL3, CCL4, CCL5, CCL19, CCL20,CD40L, CNTF, CTGF, CXCL1, CXCL2, CXCL8, edn-1, aFGF, bFGF, G-CSF, glutamate, GM-CSF, IFN-alpha, IFN-beta, IFN-gamma, IGF-1, IL-1alpha, IL-1beta, IL-2, Il-4, IL-6, IL-10, IL-12, LIF, MIP-2, NGF, nitric oxide, NT3, taurine, TGF-beta, TNF-alpha, TNF-beta. subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "activated astrocyte" EXACT [] synonym: "mature astrocytic glia" EXACT [] is_a: CL:0000127 ! astrocyte property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0002627" xsd:string {name="mature astrocyte on CELLxGENE CellGuide"} property_value: terms:description "Mature astrocytes are specialized glial cells found primarily in the central nervous system (CNS), which consists of the brain and the spinal cord. They are named aftertheir star-like shape. Mature astrocytes are derived from radial glia, with the transition from radial glia to immature astrocytes, followed by maturation into the final functionally specialized form. They are further classified into two basic types: protoplasmic astrocytes present mainly in the grey matter and fibrous astrocytes in the white matter.\nFunctionally, mature astrocytes play a central role in both the structure and function of the CNS through regulation of neurons. By secreting molecules, such as cytokines, that influence the formation, functioning, and elimination of synapses, they actively participate in the formation and modulation of synaptic connections between neurons. Additionally, they also possess a unique capability known as gliotransmission, referring to the astrocytes' ability to respond to and release neurotransmitters, which impacts neuronal signaling.\nThe mature astrocytes also maintain the brain's homeostasis, which includes controlling the chemical environment, providing nutrients to nervous tissues, regulating blood flow, responding to injury, and maintaining the blood-brain barrier, a crucial defense mechanism of the brain. They metabolize neurotransmitters like glutamate to prevent neurotoxicity and help in the detoxification process. Furthermore, these cells play a vital role in neuroinflammation and reactive gliosis, a response to trauma or neurodegenerative diseases, and assist in repairing damaged neural tissues. Thus, the versatile mature astrocytes play multiple roles and significantly contribute to the correct functioning and reparative process of the CNS.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1002/glia.22836", xref="DOI:10.1002/glia.23908", xref="DOI:10.1002/jnr.24922", xref="DOI:10.1016/j.neuron.2017.09.056", xref="DOI:10.1177/1073858409342593"} [Term] id: CL:0002628 name: immature microglial cell def: "An immature microglial cell with a ramified morphology." [GOC:dsd, PMID:18396103, PMID:19461673] comment: Immature microglia are reportedly CD34-positive, CD163-negative, MHCI-negative, MHCII-negative. subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "immature microglia" EXACT [] synonym: "quiescent microglia" EXACT [PMID:18396103] synonym: "resting microglia" EXACT [PMID:18396103] is_a: CL:0000129 ! microglial cell [Term] id: CL:0002629 name: mature microglial cell def: "A mature microglial cell that has changed shape to an amoeboid morphology and is capable of cytokine production and antigen presentation." [GOC:dsd, PMID:11517395, PMID:14612429, PMID:15246020, PMID:16177057, PMID:18396103, PMID:20021364] comment: Mature microglia are reportedly CCR2-positive, CD4-positive, CD9-positive, CD11a-positive, CD11b-positive, CD11c-positive, CD13-positive, CD16-positive, CDw17-positive, CD18-positive, CD21-positive, CD26-negative, CD32-positive, CD35-positive, CD36-positive, CD40-positive, CD44-positive, CD45-positive, CD53-positive, CD54-positive, CD56-negative, CD58-positive, CD63-positive, CD64-positive, CD66-positive, CD80-positive, CD86-positive, CD87-positive, CD92-positive, CD106-positive, CD107a-positive, CD147-positive, CD155-positive, CD162-positive, CD163-positive, CD171-negative, CD200R-positive, CXCR3-positive, CX3CR1-positive, fibronectin-positive, GD3-positive, GLUT1-positive, GLUT3-negative, GLUT5-positive, MHCI-positive, MHCII-positive, P2X4-positive, RFD7-negative, RGS5-negative, alpha-SMA-negative, vimentin-positive, and vwf-negative. Mature microglia are capable of producing BDNF, CCL3, CCL5, CCL7, CCL8, CCL9, CCL19, CCL20,CD40L, CSF, CXCL1, CXCL2, CXCL4, CXCL5, CXCL8, CXCL9, CXCL10, glutamate, IL-1beta, IL-1ra, IL-3, IL-6, IL-10, IL-12, LT, MMP-2, MMP-9, NGF, nitric oxide, ROS, TGF-beta, TNF-alpha. subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "activated microglia" EXACT [PMID:18396103] synonym: "mature microglia" EXACT [] synonym: "reactive microglia" EXACT [PMID:18396103] is_a: CL:0000129 {is_inferred="true"} ! microglial cell intersection_of: CL:0000129 ! microglial cell intersection_of: RO:0002215 GO:0001816 ! capable of cytokine production intersection_of: RO:0002215 GO:0002536 ! capable of respiratory burst involved in inflammatory response intersection_of: RO:0002215 GO:0002537 ! capable of nitric oxide production involved in inflammatory response intersection_of: RO:0002215 GO:0006909 ! capable of phagocytosis intersection_of: RO:0002215 GO:0019882 ! capable of antigen processing and presentation relationship: RO:0002215 GO:0001816 ! capable of cytokine production relationship: RO:0002215 GO:0002536 ! capable of respiratory burst involved in inflammatory response relationship: RO:0002215 GO:0002537 ! capable of nitric oxide production involved in inflammatory response property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0002629" xsd:string {name="mature microglial cell on CELLxGENE CellGuide"} property_value: terms:description "Mature microglial cells represented one of the macrophage populations within the central nervous system (CNS). Microglial cells serve as the primary immune defense mechanism within the CNS, playing active roles in maintaining brain homeostasis and responding to pathological processes. In response to pathogens and injuries, microglial cells mature and change their morphology from a ramified shape with small processes (normal state) to an amoeboid shape (mature state).\nMature microglial cells possess multiple functional abilities, thereby enabling them to execute diverse roles in order to maintain the health of surrounding neural cells. They act to clear away cellular debris, dead neurons, or plaque formations through the process of phagocytosis. They are also continuously scanning their environment and are able to detect subtle changes in the neural landscape caused by injury, disease, or infection. Upon detection of such changes, these cells become activated and present antigens and secrete cytokines and chemokines to initiate an inflammation response, which sustains the brain’s defense against injurious agents.\nTheir role is not solely destructive or defensive: mature microglial cells also contribute to neurodevelopment by guiding the formation of neural circuits, synaptogenesis, and remodeling. Furthermore, they assist in managing synaptic plasticity, a key process in learning and memory functions. While the dysregulation of microglial cells has been implicated in various neurodegenerative diseases, they are also regarded as potential therapeutic targets for such conditions, given their crucial roles in maintaining CNS health.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1111/j.1745-7254.2007.00625.x", xref="DOI:10.1111/jnc.15689", xref="DOI:10.3389/fimmu.2022.997786", xref="DOI:10.4103/1673-5374.226386", xref="DOI:10.4103/1673-5374.322423"} [Term] id: CL:0002630 name: actinomycete-type spore def: "A spore formed from bacteria in the order Actinomycetales." [GO:0034304, GOC:tfm] is_a: CL:0000520 ! prokaryotic cell property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2011-06-16T01:01:41Z [Term] id: CL:0002631 name: epithelial cell of upper respiratory tract def: "Any epithelial cell that is part of some upper respiratory tract epithelium." [FBC:Autogenerated] subset: human_subset subset: mouse_subset is_a: CL:0002368 ! respiratory tract epithelial cell intersection_of: CL:0000066 ! epithelial cell intersection_of: BFO:0000050 UBERON:0004814 ! part of upper respiratory tract epithelium relationship: BFO:0000050 UBERON:0004814 ! part of upper respiratory tract epithelium property_value: skos:prefLabel "epithelial cell of upper respiratory tract" xsd:string property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2011-06-21T12:28:55Z [Term] id: CL:0002632 name: epithelial cell of lower respiratory tract def: "Any epithelial cell that is part of some lower respiratory tract epithelium." [FBC:Autogenerated] subset: cellxgene_subset subset: human_subset subset: mouse_subset is_a: CL:0002368 ! respiratory tract epithelial cell intersection_of: CL:0000066 ! epithelial cell intersection_of: BFO:0000050 UBERON:0004815 ! part of lower respiratory tract epithelium relationship: BFO:0000050 UBERON:0004815 ! part of lower respiratory tract epithelium property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2011-06-21T12:29:31Z [Term] id: CL:0002633 name: respiratory basal cell def: "A basal cell in the respiratory tract." [GOC:tfm, PMID:20699479] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "airway basal cell" EXACT [] synonym: "airway basal stem cell" EXACT [] is_a: CL:0000646 ! basal cell intersection_of: CL:0000646 ! basal cell intersection_of: BFO:0000050 UBERON:0004802 ! part of respiratory tract epithelium relationship: BFO:0000050 UBERON:0004802 ! part of respiratory tract epithelium property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0002633" xsd:string {name="respiratory basal cell on CELLxGENE CellGuide"} property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 property_value: terms:description "Respiratory basal cells are highly specialized cells that serve a crucial role in the human airway epithelium, predominantly found lining the surfaces of the trachea and bronchi. These cells exhibit a distinctive columnar shape and are attached directly to the basal lamina. They are characterized by the presence of high amounts of cytoplasmic keratins, predominantly keratin 5 and 14, and transcription factor tumor protein (tp63), which set them apart from other types of lung epithelial cells such as ciliated cells and secretory cells. \nBasal cells are essential for maintaining airway integrity. They make up one third of all respiratory epithelial cells and serve as stem cells as they can transform into different cell types, like goblet cells, ciliated cells, and club cells, when needed for homeostatic maintenance of the epithelial barrier or to repair and restore a healthy cellular environment after injury.\nTheir position at the interface between the internal environment and the external atmosphere makes these cells a first line of defense against air-borne irritants, allergens, and pathogens. Their robust, intrinsic reparative properties facilitate effective recovery from such adversities. However, damage to respiratory basal cells or abnormalities in their function are associated with several respiratory pathologies such as asthma, chronic obstructive pulmonary disease, and lung cancer. Therefore, understanding these cells' function, and their role in disease, is crucial for the development of new therapeutic strategies for respiratory disorders.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1186/s12931-022-02042-5", xref="DOI:10.3389/falgy.2021.787128", xref="DOI:110.1038/s41385-020-00370-7"} creation_date: 2011-06-21T03:11:10Z [Term] id: CL:0002634 name: epithelial cell of anal column def: "An epithelial cell of the anal column." [GOC:tfm] subset: human_subset subset: mouse_subset is_a: CL:0002253 ! epithelial cell of large intestine intersection_of: CL:0000066 ! epithelial cell intersection_of: BFO:0000050 UBERON:0009882 ! part of anal column relationship: BFO:0000050 UBERON:0009882 ! part of anal column property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2011-07-08T12:11:38Z [Term] id: CL:0002635 name: nonkeratinized epithelial cell of anal column def: "A nonkeratinized epithelial cell of the anal canal." [GOC:tfm] subset: human_subset subset: mouse_subset xref: FMA:263146 is_a: CL:0002634 ! epithelial cell of anal column property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2011-07-08T02:05:33Z [Term] id: CL:0002636 name: nonkeratinized epithelial cell of inferior part of anal canal def: "A nonkeratinized cell epithleial cell of the inferior part of the anal canal." [GOC:tfm] subset: human_subset subset: mouse_subset xref: FMA:263144 is_a: CL:0002635 ! nonkeratinized epithelial cell of anal column is_a: CL:1000438 ! epithelial cell of wall of inferior part of anal canal property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2011-07-08T02:06:53Z [Term] id: CL:0002637 name: keratinized epithelial cell of the anal canal def: "An epithelial cell of the anal canal that is keratinized. This cell type is found towards the lower, rectal end of the anal canal." [GOC:tfm] subset: human_subset subset: mouse_subset is_a: CL:0000237 ! keratinizing barrier epithelial cell is_a: CL:0002634 ! epithelial cell of anal column intersection_of: CL:0000237 ! keratinizing barrier epithelial cell intersection_of: BFO:0000050 UBERON:0000159 ! part of anal canal property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2011-07-08T02:08:40Z [Term] id: CL:0002638 name: bronchioalveolar stem cell def: "A respiratory stem cell found at the junction of the terminal (conductive) bronchiole and the respiratory bronchiole. This cell types gives rise to alveolar cell types and club cells in response to lung injury. This cell type expresses markers Scgb1a1 and Sftpc." [GOC:tfm, MP:0011691, PMID:15960971] subset: human_subset subset: mouse_subset synonym: "basal epithelial cell of bronchioalveolar duct junction" EXACT [] synonym: "BASC" EXACT [] is_a: CL:0002633 {is_inferred="true"} ! respiratory basal cell relationship: BFO:0000050 UBERON:0002051 ! part of epithelium of bronchiole relationship: BFO:0000050 UBERON:0004903 ! part of bronchoalveolar duct junction property_value: terms:contributor http://orcid.org/0000-0001-7258-9596 property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2011-06-21T03:26:08Z [Term] id: CL:0002639 name: amniotic stem cell def: "An amniotic stem cell is a mesenchymalstem cell extracted from amniotic fluid. Amniotic stem cells are able to differentiate into various tissue type such as skin, cartilage, cardiac tissue, nerves, muscle, and bone" [GOC:tfm, PMID:20942606] comment: Not clear to me if amniotic stem cell is a different cell type from amnion mesenchymal stem cells. They are treated as distinct in the literature as isolations methods are different, so I will keep them as separate terms for now. subset: human_subset subset: mouse_subset is_a: CL:0000134 ! mesenchymal stem cell is_a: CL:0002323 ! amniocyte property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2011-06-21T03:55:39Z [Term] id: CL:0002640 name: amniotic epithelial stem cell def: "An epithelial fate stem cell derived form the amnion membrane." [GOC:tfm, PMID:20446274] subset: human_subset subset: mouse_subset is_a: CL:0000036 ! epithelial fate stem cell property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2011-06-21T04:06:17Z [Term] id: CL:0002641 name: epithelial cell of esophageal gland proper def: "An epithelial cell of the esophageal gland proper." [GOC:tfm] subset: human_subset subset: mouse_subset xref: FMA:256141 is_a: CL:0002657 ! glandular cell of esophagus property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2011-07-08T02:16:51Z [Term] id: CL:0002642 name: epithelial cell of esophageal cardiac gland def: "An epithelial cell of the esophageal cardiac gland that occurs both in the proximal and distal esophagus, within the lamina propia." [GOC:tfm, http://web.mac.com/wjkrause/iWeb/Histology/Blog/E3FA5916-1AA9-4885-B579-5051838D98CB.html] subset: human_subset subset: mouse_subset xref: FMA:256143 is_a: CL:0002657 ! glandular cell of esophagus property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2011-07-08T02:16:54Z [Term] id: CL:0002643 name: nonkeratinized cell of stratum corneum of esophageal epithelium def: "An epithelial cell of stratum corneum of esophageal epithelium that lacks keratin." [GOC:tfm] subset: human_subset subset: mouse_subset xref: FMA:263148 is_a: CL:0002654 ! epithelial cell of stratum corneum of esophageal epithelium property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2011-07-08T02:22:09Z [Term] id: CL:0002644 name: endo-epithelial cell of tympanic part of viscerocranial mucosa def: "An endothelial cell of viscerocranial mucosa that is part of the tympanic region of the viscerocranial mucosa." [GOC:tfm] subset: human_subset subset: mouse_subset xref: FMA:70628 is_a: CL:0002261 ! endothelial cell of viscerocranial mucosa property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2011-07-08T02:25:44Z [Term] id: CL:0002645 name: endo-epithelial cell of pharyngotympanic part of viscerocranial mucosa def: "An endocranial viscerocranial mucosa cell that is part of viscerocranial mucosa." [GOC:tfm] subset: human_subset subset: mouse_subset xref: FMA:70629 is_a: CL:0002261 ! endothelial cell of viscerocranial mucosa property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2011-07-08T02:25:46Z [Term] id: CL:0002646 name: obsolete epithelial cell of buccal part of viscerocranial mucosa def: "An ecto-epithelial cell of the buccal region of the viscerocranial mucosa." [GOC:tfm] xref: FMA:70577 property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 is_obsolete: true creation_date: 2011-07-08T02:34:12Z [Term] id: CL:0002647 name: obsolete epithelial cell of anterior palatal part of viscerocranial mucosa def: "An ecto-epithelial cell of the palatal region of the viscerocranial mucosa." [GOC:tfm] xref: FMA:70580 property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 is_obsolete: true creation_date: 2011-07-08T02:34:14Z [Term] id: CL:0002648 name: obsolete epithelial cell of nasal part of viscerocranial mucosa def: "An ecto-epithelial cell of the nasal region of the viscerocranial mucosa." [GOC:tfm] xref: FMA:70554 property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 is_obsolete: true creation_date: 2011-07-08T02:36:06Z [Term] id: CL:0002649 name: obsolete epithelial cell of gingival part of viscerocranial mucosa def: "An ecto-epithelial cell of the gingival region of the viscerocranial mucosa." [GOC:tfm] xref: FMA:70579 property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 is_obsolete: true creation_date: 2011-07-08T02:36:11Z [Term] id: CL:0002650 name: obsolete epithelial cell of paranasal sinus part of viscerocranial mucosa def: "An ecto-epithelial cell of the paranasal region of the viscerocranial mucosa." [GOC:tfm] xref: FMA:70578 property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 is_obsolete: true creation_date: 2011-07-08T02:38:18Z [Term] id: CL:0002651 name: endothelial cell of venous sinus of spleen def: "An endothelial cell that is part of the venous sinus of spleen. This endothelial cell has an elongated, spindle-shaped, flattened morphology that is parallel to long axis of sinus. This cell type rests on a basement membrane interrupted by numerous narrow slits." [GOC:tfm] subset: human_subset subset: mouse_subset synonym: "stave cell" EXACT [FMA:62817] xref: FMA:72140 is_a: CL:0002262 ! endothelial cell of sinusoid property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2011-07-08T03:06:49Z [Term] id: CL:0002652 name: endothelial cell of high endothelial venule def: "A venule endothelial cell that is cubodial, expresses leukocyte-specific receptors, and allows for passage of lymphocytes into bloodstream." [GOC:tfm, PMID:20726857] comment: Markers expressed on HEV include: MAdCAM-1,PNAd (sulfated and glycosylated molecules, i.e. GlyCAM-1, CD34, endomucin, nepmucin), ICAM-1, ICAM-2,Fuc-TVII, beta 3GlcNAcT-3, GlcNAc6ST2,CCL21, CCL19, CXCL13, CXCL12, Autotaxin, DARC, angiomodulin, LRHG. subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "endothelial cell of postcapillary venule of lymph node" BROAD [] synonym: "HEV cell" EXACT [] xref: FMA:67759 is_a: CL:1000414 ! endothelial cell of venule intersection_of: CL:0002139 ! endothelial cell of vascular tree intersection_of: BFO:0000050 UBERON:8410037 ! part of high endothelial venule relationship: BFO:0000050 UBERON:8410037 ! part of high endothelial venule property_value: RO:0002175 NCBITaxon:9606 property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2011-07-08T03:14:10Z [Term] id: CL:0002653 name: squamous endothelial cell def: "A squamous shaped endothelial cell." [GOC:dos] subset: human_subset subset: mouse_subset is_a: CL:0000115 ! endothelial cell property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2011-07-08T03:31:25Z [Term] id: CL:0002654 name: epithelial cell of stratum corneum of esophageal epithelium def: "An epithelial cell of stratum corneum of esophageal epithelium." [GOC:tfm] subset: human_subset subset: mouse_subset xref: FMA:70733 is_a: CL:0002252 ! epithelial cell of esophagus property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2011-07-08T03:46:35Z [Term] id: CL:0002655 name: epithelial cell of stratum spinosum of esophageal epithelium def: "An epithelial cell of stratum spinosum of esophageal epithelium." [GOC:tfm] subset: human_subset subset: mouse_subset xref: FMA:70732 is_a: CL:0002252 ! epithelial cell of esophagus property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2011-07-08T03:48:26Z [Term] id: CL:0002656 name: glandular endometrial unciliated epithelial cell def: "A glandular epithelial cell of the endometrium. Following ovulation, these cells secrete a glycogen-rich substance known as histotroph or uterine milk, which nourishes the embryo if implantation occurs." [GOC:tfm, PMID:25023676] subset: human_subset subset: mouse_subset synonym: "glandular cell of endometrium" BROAD [] xref: FMA:86489 is_a: CL:0000150 ! glandular secretory epithelial cell is_a: CL:0000152 ! exocrine cell is_a: CL:0009084 ! glandular epithelial cell of endometrium is_a: CL:1001591 ! oviduct secretory cell intersection_of: CL:0000066 ! epithelial cell intersection_of: BFO:0000050 UBERON:0002451 ! part of endometrial gland intersection_of: RO:0002215 GO:0032940 ! capable of secretion by cell relationship: BFO:0000050 UBERON:0002451 ! part of endometrial gland property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2011-07-08T03:54:08Z [Term] id: CL:0002657 name: glandular cell of esophagus def: "A glandular epithelial cell of the esophagus." [GOC:tfm] subset: cellxgene_subset subset: human_subset subset: mouse_subset xref: FMA:86548 is_a: CL:0000150 {is_inferred="true"} ! glandular secretory epithelial cell is_a: CL:0002252 {is_inferred="true"} ! epithelial cell of esophagus intersection_of: CL:0000150 ! glandular secretory epithelial cell intersection_of: BFO:0000050 UBERON:0001976 ! part of epithelium of esophagus property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2011-07-08T03:55:57Z [Term] id: CL:0002658 name: glandular cell of the large intestine def: "A glandular epithelial cell of the large intestine." [GOC:tfm] subset: human_subset subset: mouse_subset xref: FMA:87194 is_a: CL:0000150 {is_inferred="true"} ! glandular secretory epithelial cell is_a: CL:0002253 ! epithelial cell of large intestine intersection_of: CL:0000150 ! glandular secretory epithelial cell intersection_of: BFO:0000050 UBERON:0000059 ! part of large intestine property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2011-07-08T04:03:01Z [Term] id: CL:0002659 name: glandular epithelial cell of stomach def: "A glandular epithelial cell that is part of the stomach." [GOC:tfm] subset: human_subset subset: mouse_subset synonym: "glandular cell of stomach" EXACT [] xref: CALOHA:TS-1284 xref: FMA:86554 is_a: CL:0000150 ! glandular secretory epithelial cell is_a: CL:0002178 ! epithelial cell of stomach intersection_of: CL:0000150 ! glandular secretory epithelial cell intersection_of: BFO:0000050 UBERON:0001276 ! part of epithelium of stomach property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2011-07-11T01:20:35Z [Term] id: CL:0002660 name: luminal cell of acinus of lactiferous gland def: "A luminal epithelial cell of mammary gland located in acinus of structure." [GOC:tfm] comment: Consider if synonymous with mammary alveolar cell CL:0002325. Some use this term to refer to the non-lactating cell type that gives rise to the lactating cell type. subset: human_subset subset: mouse_subset xref: FMA:74505 is_a: CL:0002326 ! luminal epithelial cell of mammary gland property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2011-07-11T01:44:31Z [Term] id: CL:0002661 name: luminal cell of lactiferous terminal ductal lobular unit def: "A luminal cell of terminal ducts, i.e.e the terminal branch of a lactiferous duct which alveolar cells drain into." [GOC:tfm] subset: human_subset subset: mouse_subset xref: FMA:87168 is_a: CL:0002662 ! luminal cell of lactiferous duct property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2011-07-11T01:44:33Z [Term] id: CL:0002662 name: luminal cell of lactiferous duct def: "A luminal epithelial cell of the lactiferous duct. This cuboidal epithelial cell expresses keratin-18 and is estrogen-receptor alpha positive." [GOC:tfm, PMID:19022771] subset: human_subset subset: mouse_subset xref: FMA:74504 is_a: CL:0002326 ! luminal epithelial cell of mammary gland property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2011-07-11T01:44:48Z [Term] id: CL:0002663 name: myocardial endocrine cell of atrium def: "A myocardial endocrine cell that is part of the atrium." [GOC:tfm] subset: human_subset subset: mouse_subset xref: FMA:83389 is_a: CL:0002074 {is_inferred="true"} ! myocardial endocrine cell intersection_of: CL:0002074 ! myocardial endocrine cell intersection_of: BFO:0000050 UBERON:0002081 ! part of cardiac atrium relationship: BFO:0000050 UBERON:0002081 ! part of cardiac atrium property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2011-07-11T02:45:39Z [Term] id: CL:0002664 name: cardioblast def: "A stem cell that can give rise to multiple cell types (i.e. smooth muscle, endothelial) in the developing heart." [GOC:tfm, PMID:19745164] comment: Discrepancy in develops from origins prevents me from making the assertion that cardioblasts give rise to all instances of cardiocytes as we state cardiac muscle cells develop from cardiac myoblast, which in turn develop from muscle stem cell. subset: human_subset subset: mouse_subset synonym: "cardiovascular progenitor cell" EXACT [PMID:17519333, PMID:19745164] synonym: "CPC" RELATED OMO:0003000 [PMID:19745164] is_a: CL:0000048 ! multi fate stem cell property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2011-07-11T03:15:38Z [Term] id: CL:0002665 name: otic fibrocyte def: "A mesenchymal cell within the inner ear, specifically localised to supportive connective tissues such as the spiral ligament and spiral limbus. This cell has specialised structural and molecular adaptations, and it contributes to the homeostasis of the cochlear environment by participating in ionic regulation crucial for auditory function." [GOC:tfm, PMID:18353863, PMID:37720106] subset: human_subset subset: mouse_subset synonym: "cochlear fibrocyte" NARROW [PMID:34436572] is_a: CL:0000255 ! eukaryotic cell is_a: CL:0008019 ! mesenchymal cell relationship: BFO:0000050 UBERON:0001846 ! part of internal ear property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2011-07-11T03:35:01Z [Term] id: CL:0002666 name: type 2 otic fibrocyte def: "An otic fibrocyte that underlies the spiral prominence and is part of a mesenchymal gap junction network that regulates ionic homeostasis of the endolymph." [GOC:tfm, PMID:18353863] subset: human_subset subset: mouse_subset synonym: "type II otic fibrocyte" EXACT [] synonym: "type II spiral ligament fibrocyte" EXACT [MP:0004488] is_a: CL:0002665 ! otic fibrocyte property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2011-07-11T03:40:40Z [Term] id: CL:0002667 name: type 5 otic fibrocyte def: "An otic fibrocyte that resides above the stria vasularis and is part of a mesenchymal gap junction network that regulates ionic homeostasis of the endolymph." [GOC:tfm, PMID:18353863] subset: human_subset subset: mouse_subset synonym: "type V otic fibrocyte" EXACT [] synonym: "type V spiral ligament fibrocyte" EXACT [] is_a: CL:0002665 ! otic fibrocyte property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2011-07-11T03:40:42Z [Term] id: CL:0002668 name: type 4 otic fibrocyte def: "An otic fibrocyte that is lateral to the basilar membrane and anchoris it to the lateral wall." [GOC:tfm, PMID:18353863] subset: human_subset subset: mouse_subset synonym: "type IV otic fibrocyte" EXACT [] synonym: "type IV spiral ligament fibrocyte" EXACT [MP:0004490] is_a: CL:0002665 ! otic fibrocyte property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2011-07-11T03:40:46Z [Term] id: CL:0002669 name: type 3 otic fibrocyte def: "An otic fibrocyte that lines the otic capsule." [GOC:tfm, PMID:18353863] subset: human_subset subset: mouse_subset synonym: "type III otic fibrocyte" EXACT [] synonym: "type III spiral ligament fibrocyte" EXACT [MP:0004489] is_a: CL:0002665 ! otic fibrocyte property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2011-07-11T03:40:50Z [Term] id: CL:0002670 name: type 1 otic fibrocyte def: "An otic fibrocyte that underlies the stria vascularis and is part of a mesenchymal gap junction network that regulates ionic homeostasis of the endolymph." [GOC:tfm, PMID:18353863] subset: human_subset subset: mouse_subset synonym: "type I otic fibrocyte" EXACT [] synonym: "type I spiral ligament fibrocyte" EXACT [MP:0004487] is_a: CL:0002665 ! otic fibrocyte property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2011-07-11T03:39:27Z [Term] id: CL:0002671 name: endothelial stalk cell def: "An endothelial stalk cell is a specialized endothelial cell that follows behind the tip cell of an angiogenic sprout." [GOC:tfm, PMID:21521739] subset: cellxgene_subset subset: human_subset subset: mouse_subset is_a: CL:0000071 ! blood vessel endothelial cell property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0002671" xsd:string {name="endothelial stalk cell on CELLxGENE CellGuide"} property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 property_value: terms:description "Endothelial stalk cells are specialized vascular cells vital in angiogenesis, a process through which new blood vessels are formed from pre-existing ones; specifically, endothelial stalk cells are involved in sprouting angiogenesis, where they help form the body of new blood vessels. \nVascular sprouting relies on the coordinated activity of migrating endothelial tip cells at the forefront and proliferating stalk cells that elongate the sprout. The process is tightly controlled by different growths factors: Vascular Endothelial Growth Factor acts on endothelial cells, inducing them to become endothelial tip cells that initiate sprouting. After sprouting initiation, activation of Notch signaling suppresses differentiation toward a tip cell phenotype and some of the endothelial cells differentiate into stalk cells, which follow tip cells, multiply, and elongate to provide a structural backbone to the growing vessel sprout. \nIn contrast to endothelial tip cells, which migrate and lead the angiogenic sprout, endothelial stalk cells behind the sprouts continue forming the tube or lumen for blood flow and facilitate maturation and stability of the new vessel. The delicate balance between the activities of stalk and tip cells during angiogenesis is crucial to build a functional vascular network. Dysfunctions in endothelial stalk cells can lead to pathological conditions such as impaired wound healing, unregulated tumor growth, and metastasis due to abnormal angiogenesis.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1007/s12079-019-00511-z", xref="DOI:10.1016/j.cmet.2013.08.001", xref="DOI:10.1101/cshperspect.a006569", xref="DOI:10.3389/fcell.2021.642352"} creation_date: 2011-08-16T01:49:32Z [Term] id: CL:0002672 name: retinal progenitor cell def: "A multi-fate stem cell that can give rise to different retinal cell types including rod and cone cells." [GOC:tfm, PMID:20959166, PMID:21148186] subset: cellxgene_subset subset: human_subset subset: mouse_subset is_a: BFO:0000002 is_a: CL:0000048 ! multi fate stem cell relationship: RO:0002202 CL:0000133 ! develops from neurectodermal cell property_value: skos:prefLabel "retinal progenitor cell" xsd:string property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2011-08-16T02:38:01Z [Term] id: CL:0002673 name: tongue muscle cell def: "A skeletal muscle cell that is part of the tongue." [GOC:tfm, PMID:18816858] subset: cellxgene_subset subset: human_subset subset: mouse_subset is_a: CL:0008002 ! skeletal muscle fiber intersection_of: CL:0008002 ! skeletal muscle fiber intersection_of: BFO:0000050 UBERON:0000378 ! part of tongue muscle relationship: BFO:0000050 UBERON:0000378 ! part of tongue muscle property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0002673" xsd:string {name="tongue muscle cell on CELLxGENE CellGuide"} property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 property_value: terms:description "Tongue muscle cells are responsible for essential functions like mastication, deglutition (swallowing), phonation (speech), and taste receptivity. They can be classified into two functional classes - extrinsic and intrinsic muscle cells. \nThe extrinsic tongue muscle cells originate outside the tongue and are primarily involved in determining the position of the tongue within the mouth. Muscle groups such as the genioglossus, hyoglossus, and styloglossus are composed of these extrinsic muscle cells and grant the tongue its wide range of motion.\nThe intrinsic tongue muscle cells, on the other hand, originate and function within the tongue itself, influencing the shape of the tongue during speech, eating, and swallowing. These cells can contract to alter the tongue's shape, making it long, short, curled, or flat, as needed. Together, these two types of muscle cells allow the tongue to perform its vital functions effectively. Moreover, they play a critical role in maintaining oral health by facilitating physical cleaning of the oral cavity and assisting in the mechanical breakdown of food.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1002/ca.21011", xref="https://www.ncbi.nlm.nih.gov/books/NBK507782/", xref="https://www.ncbi.nlm.nih.gov/books/NBK554405/"} creation_date: 2011-08-16T03:10:02Z [Term] id: CL:0002674 name: H minus def: "A S. pombe mating type determined by the mat1-Mc and mat1-Mi on the mat1 locus." [GOC:tfm] synonym: "H- cell" EXACT [] is_a: CL:0000521 ! fungal cell relationship: RO:0002162 NCBITaxon:4896 ! in taxon Schizosaccharomyces pombe property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2011-08-16T03:20:53Z [Term] id: CL:0002675 name: H plus def: "A S. pombe cell type determined by mat1-Pc and mat1-Pi on the mat1 locus." [GOC:tfm] is_a: CL:0000521 ! fungal cell relationship: RO:0002162 NCBITaxon:4896 ! in taxon Schizosaccharomyces pombe property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2011-08-16T03:20:58Z [Term] id: CL:0002676 name: neural crest derived neuroblast def: "A neuroblast derived from a neural crest cell." [GOC:tfm, PMID:17407019] subset: human_subset subset: mouse_subset is_a: CL:0000031 ! neuroblast (sensu Vertebrata) relationship: RO:0002202 CL:0000333 ! develops from migratory neural crest cell property_value: skos:prefLabel "neural crest derived neuroblast" xsd:string property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2011-08-22T09:24:15Z [Term] id: CL:0002677 name: naive regulatory T cell def: "A regulatory T cell that has not encountered antigen." [GOC:tfm] comment: This cell type has been described as CD45RA-negative, but this doesn't fit with our current definition of naive T cell. subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "naive regulatory T lymphocyte" EXACT [] synonym: "naive regulatory T-cell" EXACT [] synonym: "naive regulatory T-lymphocyte" EXACT [] is_a: CL:0000792 ! CD4-positive, CD25-positive, alpha-beta regulatory T cell is_a: CL:0000898 ! naive T cell property_value: RO:0002175 NCBITaxon:9606 property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2011-08-25T03:17:21Z [Term] id: CL:0002678 name: memory regulatory T cell def: "A CD4-positive, CD25-positive alpha-beta regulatory T cell that has encountered antigen." [GOC:tfm, PMID:21739668] comment: Cell has been described as being CD45RA-positive in human, but this doesn't fit with our current definition memory T cell. subset: cellxgene_subset subset: human_subset subset: mouse_subset is_a: CL:0000792 ! CD4-positive, CD25-positive, alpha-beta regulatory T cell is_a: CL:0000897 ! CD4-positive, alpha-beta memory T cell intersection_of: CL:0000792 ! CD4-positive, CD25-positive, alpha-beta regulatory T cell intersection_of: RO:0002353 GO:0043379 ! output of memory T cell differentiation property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2011-08-25T03:17:34Z [Term] id: CL:0002679 name: natural helper lymphocyte def: "A lymphocyte found in adipose tissue that lacks lineage markers of other lymphocytes but is capable of mediating TH2 cytokine responses. This cell type is found in fat associated lymphoid clusters, proliferates in response to IL2 and produce large amounts of TH2 cytokines such as IL5, IL6 and IL13" [GOC:tfm, PMID:20023630] subset: blood_and_immune_upper_slim subset: human_subset subset: mouse_subset is_a: CL:0000542 {is_inferred="true"} ! lymphocyte intersection_of: CL:0000542 ! lymphocyte intersection_of: CL:4030046 GO:0042105 ! lacks_plasma_membrane_part alpha-beta T cell receptor complex intersection_of: CL:4030046 PR:000001002 ! lacks_plasma_membrane_part CD19 molecule intersection_of: CL:4030046 PR:000001012 ! lacks_plasma_membrane_part integrin alpha-M intersection_of: CL:4030046 PR:000001013 ! lacks_plasma_membrane_part integrin alpha-X intersection_of: CL:4030046 PR:000001020 ! lacks_plasma_membrane_part CD3 epsilon intersection_of: CL:4030046 PR:000001084 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD8 alpha chain intersection_of: CL:4030046 PR:000001874 ! lacks_plasma_membrane_part KLRB1-like protein intersection_of: CL:4030046 PR:000002981 ! lacks_plasma_membrane_part lymphocyte antigen 76 (mouse) intersection_of: RO:0002104 PR:000002065 ! has plasma membrane part mast/stem cell growth factor receptor intersection_of: RO:0002104 PR:000002979 ! has plasma membrane part lymphocyte antigen 6A-2/6E-1 relationship: CL:4030046 GO:0042105 ! lacks_plasma_membrane_part alpha-beta T cell receptor complex relationship: CL:4030046 PR:000001002 ! lacks_plasma_membrane_part CD19 molecule relationship: CL:4030046 PR:000001012 ! lacks_plasma_membrane_part integrin alpha-M relationship: CL:4030046 PR:000001013 ! lacks_plasma_membrane_part integrin alpha-X relationship: CL:4030046 PR:000001020 ! lacks_plasma_membrane_part CD3 epsilon relationship: CL:4030046 PR:000001084 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD8 alpha chain relationship: CL:4030046 PR:000001874 ! lacks_plasma_membrane_part KLRB1-like protein relationship: CL:4030046 PR:000002981 ! lacks_plasma_membrane_part lymphocyte antigen 76 (mouse) relationship: RO:0002104 PR:000002065 ! has plasma membrane part mast/stem cell growth factor receptor relationship: RO:0002104 PR:000002979 ! has plasma membrane part lymphocyte antigen 6A-2/6E-1 property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2011-08-29T10:08:02Z [Term] id: CL:0002680 name: PP cell of intestine def: "A PP cell found in intestine." [GOC:tfm, PMID:2420136, PMID:728970] subset: human_subset subset: mouse_subset is_a: CL:0000696 {is_inferred="true"} ! PP cell is_a: CL:1001516 ! intestinal enteroendocrine cell intersection_of: CL:0000696 ! PP cell intersection_of: BFO:0000050 UBERON:0001277 ! part of intestinal epithelium property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2011-09-27T11:59:01Z [Term] id: CL:0002681 name: kidney cortical cell def: "A cell that is part of a cortex of kidney." [] subset: human_subset subset: mouse_subset is_a: CL:1000497 ! kidney cell intersection_of: CL:1000497 ! kidney cell intersection_of: BFO:0000050 UBERON:0001225 ! part of cortex of kidney relationship: BFO:0000050 UBERON:0001225 ! part of cortex of kidney property_value: terms:contributor https://orcid.org/0000-0002-0956-8634 creation_date: 2011-10-25T03:49:41Z [Term] id: CL:0003001 name: bistratified retinal ganglion cell namespace: cell def: "A retinal ganglion cell that has dendrites stratified in two layers of the inner-plexiform layer." [] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "retinal ganglion D cell" EXACT [] is_a: CL:0000740 ! retinal ganglion cell is_a: CL:0004247 ! bistratified cell intersection_of: CL:0000740 ! retinal ganglion cell intersection_of: RO:0000053 PATO:0070062 ! has characteristic bistratified dendrite cell morphology property_value: terms:contributor "https://orcid.org/0000-0001-7258-9596" xsd:string property_value: terms:contributor "https://orcid.org/0000-0002-5260-9315" xsd:string [Term] id: CL:0003002 name: G1 retinal ganglion cell namespace: cell def: "A retinal ganglion cell that has a small dendritic field and a medium dendritic arbor with post sympatic terminals in sublaminar layer S3." [PMID:11978858] is_a: CL:0000740 ! retinal ganglion cell relationship: RO:0002162 NCBITaxon:9986 ! in taxon Oryctolagus cuniculus relationship: RO:0013001 UBERON:0008924 ! has synaptic IO in region sublaminar layer S3 property_value: terms:contributor "https://orcid.org/0000-0001-7258-9596" xsd:string property_value: terms:contributor "https://orcid.org/0000-0002-5260-9315" xsd:string [Term] id: CL:0003003 name: G2 retinal ganglion cell namespace: cell def: "A mono-stratified retinal ganglion cell that has a small dendritic field and a sparse dendritic arbor with post sympatic terminals in sublaminar layer S3." [PMID:11978858] is_a: CL:0000740 ! retinal ganglion cell relationship: RO:0000053 PATO:0070063 ! has characteristic monostratified dendrite cell morphology relationship: RO:0002162 NCBITaxon:9986 ! in taxon Oryctolagus cuniculus relationship: RO:0013001 UBERON:0008924 ! has synaptic IO in region sublaminar layer S3 property_value: terms:contributor "https://orcid.org/0000-0001-7258-9596" xsd:string property_value: terms:contributor "https://orcid.org/0000-0002-5260-9315" xsd:string [Term] id: CL:0003004 name: G3 retinal ganglion cell namespace: cell def: "A bistratified retinal ganglion cell that has a small dendritic field with sparse density that terminates at the intersection of the S4-S5 sublaminar level, and a second dendrite field that is medium in size and degree of arborization that terminates in sublaminar layer S2." [PMID:11978858] comment: is_a bistratified retinal ganglion cell S4-S5 dendrite field having (small dendritic field, sparse density) and second dendrite field having (medium, meduim) is_a: CL:0003001 ! bistratified retinal ganglion cell relationship: RO:0002162 NCBITaxon:9986 ! in taxon Oryctolagus cuniculus relationship: RO:0013001 UBERON:0008923 ! has synaptic IO in region sublaminar layer S2 relationship: RO:0013001 UBERON:0008925 ! has synaptic IO in region sublaminar layer S4 relationship: RO:0013001 UBERON:0009851 ! has synaptic IO in region border of sublaminar layers S4 and S5 property_value: terms:contributor "https://orcid.org/0000-0001-7258-9596" xsd:string property_value: terms:contributor "https://orcid.org/0000-0002-5260-9315" xsd:string [Term] id: CL:0003005 name: G4 retinal ganglion cell namespace: cell def: "A mono-stratified retinal ganglion cell that has a small dendritic field and dense dendritic arbor." [] comment: Masland nomenclature PMID:11978858 is_a: CL:0000740 ! retinal ganglion cell relationship: RO:0000053 PATO:0070063 ! has characteristic monostratified dendrite cell morphology relationship: RO:0002162 NCBITaxon:9986 ! in taxon Oryctolagus cuniculus property_value: terms:contributor "https://orcid.org/0000-0001-7258-9596" xsd:string property_value: terms:contributor "https://orcid.org/0000-0002-5260-9315" xsd:string [Term] id: CL:0003006 name: G4-ON retinal ganglion cell namespace: cell def: "A G4 retinal ganglion cell that has post sympatic terminals in sublaminar layers S3 and S4 and is depolarized by illumination of its receptive field center." [PMID:11978858] is_a: CL:0003005 ! G4 retinal ganglion cell is_a: CL:4023032 ! ON retinal ganglion cell relationship: RO:0013001 UBERON:0008924 ! has synaptic IO in region sublaminar layer S3 relationship: RO:0013001 UBERON:0008925 ! has synaptic IO in region sublaminar layer S4 property_value: terms:contributor "https://orcid.org/0000-0001-7258-9596" xsd:string property_value: terms:contributor "https://orcid.org/0000-0002-5260-9315" xsd:string [Term] id: CL:0003007 name: G4-OFF retinal ganglion cell namespace: cell def: "A G4 retinal ganglion cell that has post sympatic terminals in sublaminar layers S2 and S3 and is depolarized by decreased illumination of their receptive field center" [] comment: Masland nomenclature PMID:11978858 is_a: CL:0003005 ! G4 retinal ganglion cell is_a: CL:4023033 ! OFF retinal ganglion cell relationship: RO:0013001 UBERON:0008923 ! has synaptic IO in region sublaminar layer S2 relationship: RO:0013001 UBERON:0008924 ! has synaptic IO in region sublaminar layer S3 property_value: terms:contributor "https://orcid.org/0000-0001-7258-9596" xsd:string property_value: terms:contributor "https://orcid.org/0000-0002-5260-9315" xsd:string [Term] id: CL:0003008 name: G5 retinal ganglion cell namespace: cell def: "A mono-stratified retinal ganglion cell that has a medium dendritic field and a medium dendritic arbor with post sympatic terminals in sublaminar layer S2." [PMID:11978858] is_a: CL:0000740 ! retinal ganglion cell relationship: RO:0000053 PATO:0070063 ! has characteristic monostratified dendrite cell morphology relationship: RO:0002162 NCBITaxon:9986 ! in taxon Oryctolagus cuniculus relationship: RO:0013001 UBERON:0008923 ! has synaptic IO in region sublaminar layer S2 property_value: terms:contributor "https://orcid.org/0000-0001-7258-9596" xsd:string property_value: terms:contributor "https://orcid.org/0000-0002-5260-9315" xsd:string [Term] id: CL:0003009 name: G6 retinal ganglion cell namespace: cell def: "A mono-stratified retinal ganglion cell that has a medium dendritic field and a sparse dendritic arbor with post sympatic terminals in sublaminar layer S4 and S5." [PMID:11978858] is_a: CL:0000740 ! retinal ganglion cell relationship: RO:0000053 PATO:0070063 ! has characteristic monostratified dendrite cell morphology relationship: RO:0002162 NCBITaxon:9986 ! in taxon Oryctolagus cuniculus relationship: RO:0013001 UBERON:0008925 ! has synaptic IO in region sublaminar layer S4 relationship: RO:0013001 UBERON:0008926 ! has synaptic IO in region sublaminar layer S5 property_value: terms:contributor "https://orcid.org/0000-0001-7258-9596" xsd:string property_value: terms:contributor "https://orcid.org/0000-0002-5260-9315" xsd:string [Term] id: CL:0003010 name: G7 retinal ganglion cell namespace: cell def: "A bistratified retinal ganglion cell that has a dendrite field that terminates in sublaminar layer S2 and a second dendrite field that terminates in sublaminar layer S4." [PMID:11978858] synonym: "ON-OFF DS" EXACT [] is_a: CL:0003001 ! bistratified retinal ganglion cell relationship: RO:0002162 NCBITaxon:9986 ! in taxon Oryctolagus cuniculus relationship: RO:0013001 UBERON:0008923 ! has synaptic IO in region sublaminar layer S2 relationship: RO:0013001 UBERON:0008925 ! has synaptic IO in region sublaminar layer S4 property_value: terms:contributor "https://orcid.org/0000-0001-7258-9596" xsd:string property_value: terms:contributor "https://orcid.org/0000-0002-5260-9315" xsd:string [Term] id: CL:0003011 name: G8 retinal ganglion cell namespace: cell def: "A mono-stratified retinal ganglion cell that has a large dendritic field and a sparse dendritic arbor with post synaptic terminals in sublaminar layer S4." [PMID:11978858] is_a: CL:0000740 ! retinal ganglion cell relationship: RO:0000053 PATO:0070063 ! has characteristic monostratified dendrite cell morphology relationship: RO:0002162 NCBITaxon:9986 ! in taxon Oryctolagus cuniculus relationship: RO:0013001 UBERON:0008925 ! has synaptic IO in region sublaminar layer S4 property_value: terms:contributor "https://orcid.org/0000-0001-7258-9596" xsd:string property_value: terms:contributor "https://orcid.org/0000-0002-5260-9315" xsd:string [Term] id: CL:0003012 name: G9 retinal ganglion cell namespace: cell def: "A mono-stratified retinal ganglion cell that has a large dendritic field and a medium dendritic arbor with post synaptic terminals in sublaminar layer S1 and S2." [PMID:11978858] is_a: CL:0000740 ! retinal ganglion cell relationship: RO:0000053 PATO:0070063 ! has characteristic monostratified dendrite cell morphology relationship: RO:0002162 NCBITaxon:9986 ! in taxon Oryctolagus cuniculus relationship: RO:0013001 UBERON:0008922 ! has synaptic IO in region sublaminar layer S1 relationship: RO:0013001 UBERON:0008923 ! has synaptic IO in region sublaminar layer S2 property_value: terms:contributor "https://orcid.org/0000-0001-7258-9596" xsd:string property_value: terms:contributor "https://orcid.org/0000-0002-5260-9315" xsd:string [Term] id: CL:0003013 name: G10 retinal ganglion cell namespace: cell def: "A mono-stratified retinal ganglion cell that has a large dendritic field, a medium dendritic arbor, and a long secondary dendrite shaft with post synaptic terminals in sublaminar layer S4." [PMID:11978858] comment: Capable of ON directional sensitivity. xref: https://orcid.org/0000-0001-7258-9596 xref: https://orcid.org/0000-0002-5260-9315 is_a: CL:0000740 ! retinal ganglion cell relationship: RO:0000053 PATO:0070063 ! has characteristic monostratified dendrite cell morphology relationship: RO:0002162 NCBITaxon:9986 ! in taxon Oryctolagus cuniculus relationship: RO:0013001 UBERON:0008925 ! has synaptic IO in region sublaminar layer S4 [Term] id: CL:0003014 name: G11 retinal ganglion cell namespace: cell def: "A mono-stratified retinal ganglion cell that has a large dendritic field, a medium dendritic arbor, and a medium length secondary dendrite shaft." [PMID:11978858] comment: Is capable of brisk transient currents. xref: https://orcid.org/0000-0001-7258-9596 xref: https://orcid.org/0000-0002-5260-9315 is_a: CL:0000740 ! retinal ganglion cell relationship: RO:0000053 PATO:0070063 ! has characteristic monostratified dendrite cell morphology relationship: RO:0002162 NCBITaxon:9986 ! in taxon Oryctolagus cuniculus [Term] id: CL:0003015 name: G11-ON retinal ganglion cell namespace: cell def: "A G11 retinal ganglion cell that has post synaptic terminals in sublaminar layer S4 and is depolarized by illumination of its receptive field center." [PMID:11978858] xref: https://orcid.org/0000-0001-7258-9596 xref: https://orcid.org/0000-0002-5260-9315 is_a: CL:0003014 ! G11 retinal ganglion cell is_a: CL:4023032 ! ON retinal ganglion cell relationship: RO:0013001 UBERON:0008925 ! has synaptic IO in region sublaminar layer S4 [Term] id: CL:0003016 name: G11-OFF retinal ganglion cell namespace: cell def: "A G11 retinal ganglion cell that has post synaptic terminals in sublaminar layer S2 and is depolarized by decreased illumination of their receptive field center" [PMID:11978858] xref: https://orcid.org/0000-0001-7258-9596 xref: https://orcid.org/0000-0002-5260-9315 is_a: CL:0003014 ! G11 retinal ganglion cell is_a: CL:4023033 ! OFF retinal ganglion cell relationship: RO:0013001 UBERON:0008923 ! has synaptic IO in region sublaminar layer S2 [Term] id: CL:0003017 name: retinal ganglion cell B3 outer namespace: cell def: "A retinal ganglion B cell that has post synaptic terminals in S2." [PMID:12209831] subset: mouse_subset is_a: CL:0004183 ! retinal ganglion cell B3 relationship: RO:0013001 UBERON:0008923 ! has synaptic IO in region sublaminar layer S2 property_value: terms:contributor "https://orcid.org/0000-0001-7258-9596" xsd:string property_value: terms:contributor "https://orcid.org/0000-0002-5260-9315" xsd:string [Term] id: CL:0003018 name: retinal ganglion cell B3 inner namespace: cell def: "A retinal ganglion B3 cell with dentrites terminating in S4." [PMID:12209831] subset: mouse_subset xref: BAMS:1010 is_a: CL:0004183 ! retinal ganglion cell B3 relationship: RO:0013001 UBERON:0008925 ! has synaptic IO in region sublaminar layer S4 property_value: terms:contributor "https://orcid.org/0000-0001-7258-9596" xsd:string property_value: terms:contributor "https://orcid.org/0000-0002-5260-9315" xsd:string [Term] id: CL:0003020 name: retinal ganglion cell C outer namespace: cell def: "A retinal ganglion cell C that has post-synaptic terminals in S2." [PMID:12209831] subset: mouse_subset is_a: CL:0004116 ! retinal ganglion cell C relationship: RO:0013001 UBERON:0008923 ! has synaptic IO in region sublaminar layer S2 property_value: terms:contributor "https://orcid.org/0000-0001-7258-9596" xsd:string property_value: terms:contributor "https://orcid.org/0000-0002-5260-9315" xsd:string [Term] id: CL:0003021 name: retinal ganglion cell C4 namespace: cell def: "A retinal ganglion cell C outer that has a medium dendritic field and a dense dendritic arbor." [PMID:12209831] subset: mouse_subset is_a: CL:0003020 ! retinal ganglion cell C outer property_value: terms:contributor "https://orcid.org/0000-0001-7258-9596" xsd:string property_value: terms:contributor "https://orcid.org/0000-0002-5260-9315" xsd:string [Term] id: CL:0003022 name: retinal ganglion cell C5 namespace: cell def: "A retinal ganglion cell C outer that has medium dendritic density and field size." [PMID:12209831] subset: mouse_subset is_a: CL:0003020 ! retinal ganglion cell C outer property_value: terms:contributor "https://orcid.org/0000-0001-7258-9596" xsd:string property_value: terms:contributor "https://orcid.org/0000-0002-5260-9315" xsd:string [Term] id: CL:0003023 name: retinal ganglion cell C6 namespace: cell def: "A retinal ganglion cell C outer that has dense dendritic diversity." [PMID:12209831] subset: mouse_subset is_a: CL:0003020 ! retinal ganglion cell C outer property_value: terms:contributor "https://orcid.org/0000-0001-7258-9596" xsd:string property_value: terms:contributor "https://orcid.org/0000-0002-5260-9315" xsd:string [Term] id: CL:0003024 name: retinal ganglion cell C inner namespace: cell def: "A retinal ganglion cell C with medium cell bodies and large dendritic field." [PMID:12209831] subset: mouse_subset is_a: CL:0004116 ! retinal ganglion cell C relationship: RO:0013001 UBERON:0008925 ! has synaptic IO in region sublaminar layer S4 property_value: terms:contributor "https://orcid.org/0000-0001-7258-9596" xsd:string property_value: terms:contributor "https://orcid.org/0000-0002-5260-9315" xsd:string [Term] id: CL:0003025 name: retinal ganglion cell C3 namespace: cell def: "A retinal ganglion cell C inner that has sparse dendritic density, and large dendritic field." [PMID:12209831] subset: mouse_subset synonym: "epsilon" RELATED [] is_a: CL:0003024 ! retinal ganglion cell C inner property_value: terms:contributor "https://orcid.org/0000-0001-7258-9596" xsd:string property_value: terms:contributor "https://orcid.org/0000-0002-5260-9315" xsd:string [Term] id: CL:0003026 name: retinal ganglion cell D1 namespace: cell def: "A bistratified retinal ganglion cell that has a small dendrite fields with a sparse dendrite arbor terminating in S2 and S3." [PMID:12209831] subset: mouse_subset is_a: CL:0003001 ! bistratified retinal ganglion cell relationship: RO:0002162 NCBITaxon:10090 ! in taxon Mus musculus relationship: RO:0013001 UBERON:0008923 ! has synaptic IO in region sublaminar layer S2 relationship: RO:0013001 UBERON:0008924 ! has synaptic IO in region sublaminar layer S3 property_value: terms:contributor "https://orcid.org/0000-0001-7258-9596" xsd:string property_value: terms:contributor "https://orcid.org/0000-0002-5260-9315" xsd:string [Term] id: CL:0003027 name: retinal ganglion cell D2 namespace: cell def: "A bistratified retinal ganglion cell D cell that has medium dendritic arbor and a large dendritic field that terminates in S2 and S4." [PMID:12209831] subset: mouse_subset synonym: "iota cell" RELATED [] synonym: "ON-OFF direction selective" RELATED [] is_a: CL:0003001 ! bistratified retinal ganglion cell relationship: RO:0002162 NCBITaxon:10090 ! in taxon Mus musculus relationship: RO:0013001 UBERON:0008923 ! has synaptic IO in region sublaminar layer S2 relationship: RO:0013001 UBERON:0008925 ! has synaptic IO in region sublaminar layer S4 property_value: terms:contributor "https://orcid.org/0000-0001-7258-9596" xsd:string property_value: terms:contributor "https://orcid.org/0000-0002-5260-9315" xsd:string [Term] id: CL:0003028 name: M1 retinal ganglion cell namespace: cell def: "A monostratified retinal ganglion cell that has a small dendrite field with a dense dendrite arbor with post synaptic terminals in sublaminer layer S4." [PMID:16626866] subset: mouse_subset is_a: CL:0000740 ! retinal ganglion cell relationship: RO:0000053 PATO:0070063 ! has characteristic monostratified dendrite cell morphology relationship: RO:0002162 NCBITaxon:10090 ! in taxon Mus musculus relationship: RO:0013001 UBERON:0008925 ! has synaptic IO in region sublaminar layer S4 property_value: terms:contributor "https://orcid.org/0000-0001-7258-9596" xsd:string property_value: terms:contributor "https://orcid.org/0000-0002-5260-9315" xsd:string [Term] id: CL:0003029 name: M2 retinal ganglion cell namespace: cell def: "A monostratified retinal ganglion cell that has a small soma, a small dendrite field with a dense dendrite arbor, and post synaptic terminals in sublaminer layer S2 and S3." [PMID:16626866] subset: mouse_subset is_a: CL:0000740 ! retinal ganglion cell relationship: RO:0000053 PATO:0070063 ! has characteristic monostratified dendrite cell morphology relationship: RO:0002162 NCBITaxon:10090 ! in taxon Mus musculus relationship: RO:0013001 UBERON:0008923 ! has synaptic IO in region sublaminar layer S2 relationship: RO:0013001 UBERON:0008924 ! has synaptic IO in region sublaminar layer S3 property_value: terms:contributor "https://orcid.org/0000-0001-7258-9596" xsd:string property_value: terms:contributor "https://orcid.org/0000-0002-5260-9315" xsd:string [Term] id: CL:0003030 name: M3 retinal ganglion cell namespace: cell def: "A monostratified retinal ganglion cell that has a medium soma and a small dendrite field." [PMID:16626866] subset: mouse_subset is_a: CL:0000740 ! retinal ganglion cell relationship: RO:0000053 PATO:0070063 ! has characteristic monostratified dendrite cell morphology relationship: RO:0002162 NCBITaxon:10090 ! in taxon Mus musculus property_value: terms:contributor "https://orcid.org/0000-0001-7258-9596" xsd:string property_value: terms:contributor "https://orcid.org/0000-0002-5260-9315" xsd:string [Term] id: CL:0003031 name: M3-ON retinal ganglion cell namespace: cell def: "A monostratified retinal ganglion cell that has post synaptic terminals in sublaminar layer S4 and is depolarized by illumination of its receptive field center." [PMID:16626866] subset: mouse_subset is_a: CL:0003030 ! M3 retinal ganglion cell is_a: CL:4023032 ! ON retinal ganglion cell relationship: RO:0013001 UBERON:0008925 ! has synaptic IO in region sublaminar layer S4 property_value: terms:contributor "https://orcid.org/0000-0001-7258-9596" xsd:string property_value: terms:contributor "https://orcid.org/0000-0002-5260-9315" xsd:string [Term] id: CL:0003032 name: M3-OFF retinal ganglion cell namespace: cell def: "A monostratified retinal ganglion cell that has post synaptic terminals in sublaminar layer S2 and is depolarized by decreased illumination of their receptive field center" [PMID:16626866] subset: mouse_subset is_a: CL:0003030 ! M3 retinal ganglion cell is_a: CL:4023033 ! OFF retinal ganglion cell relationship: RO:0013001 UBERON:0008923 ! has synaptic IO in region sublaminar layer S2 property_value: terms:contributor "https://orcid.org/0000-0001-7258-9596" xsd:string property_value: terms:contributor "https://orcid.org/0000-0002-5260-9315" xsd:string [Term] id: CL:0003033 name: M4 retinal ganglion cell namespace: cell def: "A monostratified retinal ganglion cell that has a large soma, a medium dendritic field with post synaptic terminals in sublaminar layer S3." [PMID:16626866] subset: mouse_subset is_a: CL:0000740 ! retinal ganglion cell relationship: RO:0000053 PATO:0070063 ! has characteristic monostratified dendrite cell morphology relationship: RO:0002162 NCBITaxon:10090 ! in taxon Mus musculus relationship: RO:0013001 UBERON:0008924 ! has synaptic IO in region sublaminar layer S3 property_value: terms:contributor "https://orcid.org/0000-0001-7258-9596" xsd:string property_value: terms:contributor "https://orcid.org/0000-0002-5260-9315" xsd:string [Term] id: CL:0003034 name: M5 retinal ganglion cell namespace: cell def: "A monostratified retinal ganglion cell that has a small soma, an assymetric dendritic field with post synaptic terminals in sublaminar layer S3." [PMID:16626866] subset: mouse_subset is_a: CL:0000740 ! retinal ganglion cell relationship: RO:0000053 PATO:0070063 ! has characteristic monostratified dendrite cell morphology relationship: RO:0002162 NCBITaxon:10090 ! in taxon Mus musculus relationship: RO:0013001 UBERON:0008924 ! has synaptic IO in region sublaminar layer S3 property_value: terms:contributor "https://orcid.org/0000-0001-7258-9596" xsd:string property_value: terms:contributor "https://orcid.org/0000-0002-5260-9315" xsd:string [Term] id: CL:0003035 name: M6 retinal ganglion cell namespace: cell def: "A monostratified retinal ganglion cell that contains opsin." [PMID:16626866] subset: mouse_subset is_a: CL:0000740 ! retinal ganglion cell relationship: RO:0000053 PATO:0070063 ! has characteristic monostratified dendrite cell morphology relationship: RO:0002162 NCBITaxon:10090 ! in taxon Mus musculus relationship: RO:0002292 PR:000001243 ! expresses melanopsin property_value: terms:contributor "https://orcid.org/0000-0001-7258-9596" xsd:string property_value: terms:contributor "https://orcid.org/0000-0002-5260-9315" xsd:string [Term] id: CL:0003036 name: M7 retinal ganglion cell namespace: cell def: "A monostratified retinal ganglion cell with large soma and large dendritic field, with medium dendritic arbor, and has dendrites in layers 2 and 5." [PMID:16626866] subset: mouse_subset is_a: CL:0000740 ! retinal ganglion cell relationship: RO:0000053 PATO:0070063 ! has characteristic monostratified dendrite cell morphology relationship: RO:0002162 NCBITaxon:10090 ! in taxon Mus musculus property_value: terms:contributor "https://orcid.org/0000-0001-7258-9596" xsd:string property_value: terms:contributor "https://orcid.org/0000-0002-5260-9315" xsd:string [Term] id: CL:0003037 name: M7-ON retinal ganglion cell namespace: cell def: "An M7 retinal ganglion cells with synaptic terminals in S4 and is depolarized by illumination of its receptive field center." [PMID:16626866] subset: mouse_subset is_a: CL:0003036 ! M7 retinal ganglion cell is_a: CL:4023032 ! ON retinal ganglion cell relationship: RO:0013001 UBERON:0008925 ! has synaptic IO in region sublaminar layer S4 property_value: terms:contributor "https://orcid.org/0000-0001-7258-9596" xsd:string property_value: terms:contributor "https://orcid.org/0000-0002-5260-9315" xsd:string [Term] id: CL:0003038 name: M7-OFF retinal ganglion cell namespace: cell def: "An M7 retinal ganglion cells with synaptic terminals in S2 and is depolarized by decreased illumination of their receptive field center" [PMID:16626866] subset: mouse_subset is_a: CL:0003036 ! M7 retinal ganglion cell is_a: CL:4023033 ! OFF retinal ganglion cell relationship: RO:0013001 UBERON:0008923 ! has synaptic IO in region sublaminar layer S2 property_value: terms:contributor "https://orcid.org/0000-0001-7258-9596" xsd:string property_value: terms:contributor "https://orcid.org/0000-0002-5260-9315" xsd:string [Term] id: CL:0003039 name: M8 retinal ganglion cell namespace: cell def: "A monostratified retinal ganglion cell with large soma and medium dendritic field, with dense dendritic arbor." [PMID:16626866] subset: mouse_subset is_a: CL:0000740 ! retinal ganglion cell relationship: RO:0000053 PATO:0070063 ! has characteristic monostratified dendrite cell morphology relationship: RO:0002162 NCBITaxon:10090 ! in taxon Mus musculus property_value: terms:contributor "https://orcid.org/0000-0001-7258-9596" xsd:string property_value: terms:contributor "https://orcid.org/0000-0002-5260-9315" xsd:string [Term] id: CL:0003040 name: M9 retinal ganglion cell namespace: cell def: "A monostratified retinal ganglion cell with large soma and large dendritic field, with medium dendritic arbor, and has dendrites in layers 1 and 5." [PMID:16626866] subset: mouse_subset is_a: CL:0000740 ! retinal ganglion cell relationship: RO:0000053 PATO:0070063 ! has characteristic monostratified dendrite cell morphology relationship: RO:0002162 NCBITaxon:10090 ! in taxon Mus musculus property_value: terms:contributor "https://orcid.org/0000-0001-7258-9596" xsd:string property_value: terms:contributor "https://orcid.org/0000-0002-5260-9315" xsd:string [Term] id: CL:0003041 name: M9-ON retinal ganglion cell namespace: cell def: "An M9 retinal ganglion cells with synaptic terminals in S2 and is depolarized by illumination of its receptive field center." [PMID:16626866] subset: mouse_subset is_a: CL:0003040 ! M9 retinal ganglion cell is_a: CL:4023032 ! ON retinal ganglion cell relationship: RO:0013001 UBERON:0008923 ! has synaptic IO in region sublaminar layer S2 property_value: terms:contributor "https://orcid.org/0000-0001-7258-9596" xsd:string property_value: terms:contributor "https://orcid.org/0000-0002-5260-9315" xsd:string [Term] id: CL:0003042 name: M9-OFF retinal ganglion cell namespace: cell def: "An M9 retinal ganglion cell with synaptic terminals in S4 that is depolarized by decreased illumination of their receptive field center" [PMID:16626866] subset: mouse_subset is_a: CL:0003040 ! M9 retinal ganglion cell is_a: CL:4023033 ! OFF retinal ganglion cell relationship: RO:0013001 UBERON:0008925 ! has synaptic IO in region sublaminar layer S4 property_value: terms:contributor "https://orcid.org/0000-0001-7258-9596" xsd:string property_value: terms:contributor "https://orcid.org/0000-0002-5260-9315" xsd:string [Term] id: CL:0003043 name: M10 retinal ganglion cell namespace: cell def: "A monostratified retinal ganglion cell with large soma and large dendritic field, with dense dendritic arbor." [PMID:16626866] subset: mouse_subset is_a: CL:0000740 ! retinal ganglion cell relationship: RO:0000053 PATO:0070063 ! has characteristic monostratified dendrite cell morphology relationship: RO:0002162 NCBITaxon:10090 ! in taxon Mus musculus property_value: terms:contributor "https://orcid.org/0000-0001-7258-9596" xsd:string property_value: terms:contributor "https://orcid.org/0000-0002-5260-9315" xsd:string [Term] id: CL:0003044 name: M11 retinal ganglion cell namespace: cell def: "A bistratified ganglion cell with small, dense dendritic fields that terminate in S1 and S3." [PMID:16626866] subset: mouse_subset is_a: CL:0003001 ! bistratified retinal ganglion cell relationship: RO:0002162 NCBITaxon:10090 ! in taxon Mus musculus relationship: RO:0013001 UBERON:0008922 ! has synaptic IO in region sublaminar layer S1 relationship: RO:0013001 UBERON:0008924 ! has synaptic IO in region sublaminar layer S3 property_value: terms:contributor "https://orcid.org/0000-0001-7258-9596" xsd:string property_value: terms:contributor "https://orcid.org/0000-0002-5260-9315" xsd:string [Term] id: CL:0003045 name: M12 retinal ganglion cell namespace: cell def: "A bistratified ganglion cell with larger, asymetric dendritic fields that terminate in S2 and S4." [PMID:16626866] subset: mouse_subset is_a: CL:0003001 ! bistratified retinal ganglion cell relationship: RO:0002162 NCBITaxon:10090 ! in taxon Mus musculus relationship: RO:0013001 UBERON:0008923 ! has synaptic IO in region sublaminar layer S2 relationship: RO:0013001 UBERON:0008925 ! has synaptic IO in region sublaminar layer S4 property_value: terms:contributor "https://orcid.org/0000-0001-7258-9596" xsd:string property_value: terms:contributor "https://orcid.org/0000-0002-5260-9315" xsd:string [Term] id: CL:0003046 name: M13 retinal ganglion cell namespace: cell def: "A bistratifed retinal ganglion cell that has small, symmetric dendritic fields that terminate in S2 and S4." [PMID:16626866] subset: mouse_subset is_a: CL:0003001 ! bistratified retinal ganglion cell relationship: RO:0002162 NCBITaxon:10090 ! in taxon Mus musculus relationship: RO:0013001 UBERON:0008923 ! has synaptic IO in region sublaminar layer S2 relationship: RO:0013001 UBERON:0008925 ! has synaptic IO in region sublaminar layer S4 property_value: terms:contributor "https://orcid.org/0000-0001-7258-9596" xsd:string property_value: terms:contributor "https://orcid.org/0000-0002-5260-9315" xsd:string [Term] id: CL:0003047 name: M14 retinal ganglion cell namespace: cell def: "A bistratifed retinal ganglion cell that has small, symmetric dendritic fields that terminate in S1 and S4-S5." [PMID:16626866] subset: mouse_subset is_a: CL:0003001 ! bistratified retinal ganglion cell relationship: RO:0002162 NCBITaxon:10090 ! in taxon Mus musculus relationship: RO:0013001 UBERON:0008922 ! has synaptic IO in region sublaminar layer S1 relationship: RO:0013001 UBERON:0008929 ! has synaptic IO in region sublaminar layers S4 or S5 property_value: terms:contributor "https://orcid.org/0000-0001-7258-9596" xsd:string property_value: terms:contributor "https://orcid.org/0000-0002-5260-9315" xsd:string [Term] id: CL:0003048 name: L cone cell namespace: cell def: "A cone cell that detects long wavelength light. Exact peak of spectra detected differs between species. In humans, spectra peaks at 564-580 nm." [WikipediaVersioned:Cone_cell&oldid=1111888680] subset: human_subset subset: mouse_subset synonym: "L cone" EXACT [PMID:32555229] synonym: "L-cone" EXACT [PMID:29603924] synonym: "long wavelength sensitive cone" EXACT [PMID:31117170] synonym: "long- (L) wavelength-sensitive cone" EXACT [https://doi.org/10.7554/eLife.39166] synonym: "long-wavelength cone" EXACT [https://doi.org/10.1038/323623a0] is_a: CL:0000573 ! retinal cone cell relationship: BFO:0000051 PR:000001244 ! has part long-wave-sensitive opsin 1 property_value: terms:contributor "https://orcid.org/0000-0002-5260-9315" xsd:string [Term] id: CL:0003049 name: M cone cell namespace: cell def: "A cone cell that detects medium wavelength light. Exact peak of spectra detected differs between species. In humans, spectra peaks at 534-545 nm." [WikipediaVersioned:Cone_cell&oldid=1111888680] subset: human_subset subset: mouse_subset synonym: "M cone" EXACT [PMID:32555229] synonym: "M-cone" EXACT [PMID:29603924] synonym: "middle wavelength sensitive cone" EXACT [PMID:31117170] synonym: "middle- (M) wavelength-sensitive cone" EXACT [https://doi.org/10.7554/eLife.39166] synonym: "middle-wavelength-sensitive (M) cone" EXACT [https://opg.optica.org/josaa/abstract.cfm?URI=josaa-6-1-153] is_a: CL:0000573 ! retinal cone cell relationship: BFO:0000051 PR:000001224 ! has part medium-wave-sensitive opsin property_value: terms:contributor "https://orcid.org/0000-0002-5260-9315" xsd:string [Term] id: CL:0003050 name: S cone cell namespace: cell def: "A cone cell that detects short wavelength light. Exact peak of spectra detected differs between species. In humans, spectra peaks at 420-440 nm." [WikipediaVersioned:Cone_cell&oldid=1111888680] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "S cone" EXACT [PMID:32555229] synonym: "S-(short-wavelength sensitive) cone" EXACT [PMID:31117170] synonym: "S-cone" EXACT [PMID:32555229] synonym: "S-cone photoreceptor" EXACT [https://doi.org/10.7554/eLife.39166] synonym: "short wavelength sensitive cone" EXACT [PMID:31117170] synonym: "short- (S) wavelength-sensitive cone" EXACT [https://doi.org/10.7554/eLife.39166] synonym: "short-wavelength sensitive cone" EXACT [PMID:31117170] synonym: "short-wavelength-sensitive (S) cone" EXACT [https://opg.optica.org/josaa/abstract.cfm?URI=josaa-6-1-153] is_a: CL:0000573 ! retinal cone cell property_value: terms:contributor "https://orcid.org/0000-0002-5260-9315" xsd:string [Term] id: CL:0003051 name: UV cone cell namespace: cell def: "A cone cell that detects ultraviolet (UV) wavelength light." [] subset: human_subset subset: mouse_subset is_a: CL:0000573 ! retinal cone cell property_value: terms:contributor "https://orcid.org/0000-0002-5260-9315" xsd:string [Term] id: CL:0004001 name: local interneuron namespace: cell def: "An interneuron whose axon stays entirely within the gray matter region where the cell body resides." [] comment: Local interneurons form the category of interneurons whose axon stays entirely within the gray matter region where the cell body resides (Swanson, 2003, p. 245; Bota and Swanson, 2007, Fig. 3). subset: human_subset subset: mouse_subset xref: BAMS:1002 is_a: CL:0000099 ! interneuron relationship: RO:0002100 UBERON:0002020 ! has soma location gray matter [Term] id: CL:0004115 name: retinal ganglion cell B namespace: cell def: "A monostratified retinal ganglion cell with small to medium soma and small to medium dendritic field." [PMID:12209831] subset: mouse_subset is_a: CL:0000740 ! retinal ganglion cell relationship: RO:0000053 PATO:0070063 ! has characteristic monostratified dendrite cell morphology relationship: RO:0002162 NCBITaxon:10090 ! in taxon Mus musculus property_value: terms:contributor "https://orcid.org/0000-0001-7258-9596" xsd:string property_value: terms:contributor "https://orcid.org/0000-0002-5260-9315" xsd:string [Term] id: CL:0004116 name: retinal ganglion cell C namespace: cell def: "A retinal ganglion with cell medium cell bodies and medium to large dendritic fields." [PMID:12209831] comment: Group RGC cells are defined as having small to medium cell bodies and medium to large dendritic fields. Their morphology was more heterogeneous than that of Groups RGA and RGB. We classified cells with a large soma and a large dendritic field as RGA, cells with a small to medium to sized soma and a small to medium to sized dendritic field as RGB, and cells with a small to medium to sized soma but a medium to large dendritic field RGC. subset: mouse_subset is_a: CL:0000740 ! retinal ganglion cell relationship: RO:0002162 NCBITaxon:10090 ! in taxon Mus musculus property_value: terms:contributor "https://orcid.org/0000-0001-7258-9596" xsd:string property_value: terms:contributor "https://orcid.org/0000-0002-5260-9315" xsd:string [Term] id: CL:0004117 name: retinal ganglion cell A namespace: cell def: "A monostratified retinal ganglion cell with large soma and large dendritic field." [PMID:12209831] comment: This group includes all of the large bodied/large field RGCs in the rat. Group RGA cells have large somata (15 to 39 micrometers in diameter) and large, radially branching dendritic fields (235 to 748 micrometers in diameter), and many exhibit tracer coupling. subset: mouse_subset synonym: "alpha cell" EXACT [] xref: BAMS:1009 is_a: CL:0000740 ! retinal ganglion cell relationship: RO:0000053 PATO:0070063 ! has characteristic monostratified dendrite cell morphology relationship: RO:0002162 NCBITaxon:10090 ! in taxon Mus musculus property_value: terms:contributor "https://orcid.org/0000-0001-7258-9596" xsd:string property_value: terms:contributor "https://orcid.org/0000-0002-5260-9315" xsd:string [Term] id: CL:0004119 name: retinal ganglion cell B1 namespace: cell def: "A retinal ganglion cell B that has medium body size, medium dendritic field and dense dendritic arbor, and has post synaptic terminals in S2." [PMID:12209831] comment: Could not distingush between B1 and B4 from paper. {xref="PMID:12209831"} subset: mouse_subset synonym: "retinal ganglion cell B4" EXACT [] xref: BAMS:1047 is_a: CL:0004115 ! retinal ganglion cell B relationship: RO:0013001 UBERON:0008923 ! has synaptic IO in region sublaminar layer S2 property_value: terms:contributor "https://orcid.org/0000-0001-7258-9596" xsd:string property_value: terms:contributor "https://orcid.org/0000-0002-5260-9315" xsd:string [Term] id: CL:0004120 name: retinal ganglion cell A1 namespace: cell def: "A retinal ganglion A cell found in the retina with large somata, often polygonal in shape. The dendritic fields consist of three to seven stout dendrites that are sparce near soma. Dendrites terminate in S4." [PMID:12209831] subset: mouse_subset synonym: "I-2" RELATED [] synonym: "inner alpha retinal ganglion cell" EXACT [] synonym: "type I" BROAD [] xref: BAMS:1045 is_a: CL:0004117 ! retinal ganglion cell A relationship: RO:0013001 UBERON:0008925 ! has synaptic IO in region sublaminar layer S4 property_value: terms:contributor "https://orcid.org/0000-0001-7258-9596" xsd:string property_value: terms:contributor "https://orcid.org/0000-0002-5260-9315" xsd:string [Term] id: CL:0004121 name: retinal ganglion cell B2 namespace: cell def: "A retinal ganglion cell B that has a very small but very dense dendritic field, and has post synaptic terminals in S2." [PMID:12209831] subset: mouse_subset xref: BAMS:1048 is_a: CL:0004115 ! retinal ganglion cell B relationship: RO:0013001 UBERON:0008923 ! has synaptic IO in region sublaminar layer S2 property_value: terms:contributor "https://orcid.org/0000-0001-7258-9596" xsd:string property_value: terms:contributor "https://orcid.org/0000-0002-5260-9315" xsd:string [Term] id: CL:0004124 name: retinal ganglion cell C1 namespace: cell def: "A retinal ganglion cell C inner that has medium dendritic diversity." [PMID:12209831] subset: mouse_subset synonym: "delta" RELATED [] synonym: "MTN projecting" RELATED [] synonym: "ON-direction-selective" RELATED [] xref: BAMS:1050 is_a: CL:0003024 ! retinal ganglion cell C inner property_value: terms:contributor "https://orcid.org/0000-0001-7258-9596" xsd:string property_value: terms:contributor "https://orcid.org/0000-0002-5260-9315" xsd:string [Term] id: CL:0004125 name: retinal ganglion cell C2 inner namespace: cell def: "A retinal ganglion cell C inner that has dense dendritic diversity." [PMID:12209831] subset: mouse_subset xref: BAMS:1067 is_a: CL:0003024 ! retinal ganglion cell C inner property_value: terms:contributor "https://orcid.org/0000-0001-7258-9596" xsd:string property_value: terms:contributor "https://orcid.org/0000-0002-5260-9315" xsd:string [Term] id: CL:0004126 name: retinal ganglion cell C2 outer namespace: cell def: "A retinal ganglion cell C outer that has symmetrical and dense dendritic dendritic tree with a large dendritic field." [PMID:12209831] subset: mouse_subset xref: BAMS:1066 is_a: CL:0003020 ! retinal ganglion cell C outer property_value: terms:contributor "https://orcid.org/0000-0001-7258-9596" xsd:string property_value: terms:contributor "https://orcid.org/0000-0002-5260-9315" xsd:string [Term] id: CL:0004137 name: retinal ganglion cell A2 inner namespace: cell def: "A retinal ganglion A2 cell with dendrites terminating in S4." [PMID:12209831] subset: mouse_subset xref: BAMS:1061 is_a: CL:0004138 ! retinal ganglion cell A2 relationship: RO:0013001 UBERON:0008925 ! has synaptic IO in region sublaminar layer S4 property_value: terms:contributor "https://orcid.org/0000-0001-7258-9596" xsd:string property_value: terms:contributor "https://orcid.org/0000-0002-5260-9315" xsd:string [Term] id: CL:0004138 name: retinal ganglion cell A2 namespace: cell def: "A retinal ganglion A cell with dense arbor near soma." [PMID:12209831] subset: mouse_subset synonym: "I-1" RELATED [] synonym: "outer alpha retinal ganglion cell" EXACT [] synonym: "type I" RELATED [] is_a: CL:0004117 ! retinal ganglion cell A property_value: terms:contributor "https://orcid.org/0000-0001-7258-9596" xsd:string property_value: terms:contributor "https://orcid.org/0000-0002-5260-9315" xsd:string [Term] id: CL:0004139 name: retinal ganglion cell A2 outer namespace: cell def: "A retinal ganglion A2 cell with dendrites terminating in S2." [PMID:12209831] subset: mouse_subset xref: BAMS:1065 is_a: CL:0004138 ! retinal ganglion cell A2 relationship: RO:0013001 UBERON:0008923 ! has synaptic IO in region sublaminar layer S2 property_value: terms:contributor "https://orcid.org/0000-0001-7258-9596" xsd:string property_value: terms:contributor "https://orcid.org/0000-0002-5260-9315" xsd:string [Term] id: CL:0004161 name: 510 nm-cone namespace: cell def: "A cone whose sensitivity measurements have an average spectral peak of 510 nm. These cones are described in rat." [] subset: human_subset subset: mouse_subset xref: BAMS:1028 "MB" is_a: CL:0003049 ! M cone cell property_value: RO:0002175 NCBITaxon:9989 property_value: terms:contributor "https://orcid.org/0000-0002-5260-9315" xsd:string [Term] id: CL:0004162 name: 360 nm-cone namespace: cell def: "A cone whose sensitivity measurements have an average spectral peak of 358.2 nm. These cones are described in rat." [] comment: The photopigment curves that provide best fits to...sensitivity measurements have an average spectral peak of 358.2 nm. subset: human_subset subset: mouse_subset xref: BAMS:1029 "MB" is_a: CL:0003051 ! UV cone cell property_value: RO:0002175 NCBITaxon:9989 property_value: terms:contributor "https://orcid.org/0000-0002-5260-9315" xsd:string [Term] id: CL:0004183 name: retinal ganglion cell B3 namespace: cell def: "A monostratified retinal ganglion cell with medium soma, sparse dendritic tree, and medium dendritic field." [] comment: Sixty to eighty neurons with small somata (12 to 24 micrometers in diameter), small dendritic fields (99 to 289 micrometers in diameter), and small axonal diameters (04. to 07. micrometers in diameter) make up Group RGB. We classified cells with a large soma and a large dendritic field as RGA, cells with a small to medium to sized soma and a small to medium to sized dendritic field as RGB, and cells with a small to medium to sized soma but a medium to large dendritic field RGC. subset: mouse_subset xref: BAMS:1049 is_a: CL:0004115 ! retinal ganglion cell B property_value: terms:contributor "https://orcid.org/0000-0001-7258-9596" xsd:string property_value: terms:contributor "https://orcid.org/0000-0002-5260-9315" xsd:string [Term] id: CL:0004213 name: type 3a cone bipolar cell namespace: cell def: "A type of type 3 cone bipolar cell with distinctive curly dendrites." [PMID:19129389] subset: cellxgene_subset subset: human_subset subset: mouse_subset is_a: CL:0000755 ! type 3 cone bipolar cell (sensu Mus) property_value: terms:contributor "https://orcid.org/0000-0001-7258-9596" xsd:string property_value: terms:contributor "https://orcid.org/0000-0002-5260-9315" xsd:string [Term] id: CL:0004214 name: type 3b cone bipolar cell namespace: cell def: "A type of type 3 cone bipolar cell with distinctive crescent-shaped dendrites." [PMID:19129389] subset: cellxgene_subset subset: human_subset subset: mouse_subset is_a: CL:0000755 ! type 3 cone bipolar cell (sensu Mus) property_value: terms:contributor "https://orcid.org/0000-0001-7258-9596" xsd:string property_value: terms:contributor "https://orcid.org/0000-0002-5260-9315" xsd:string [Term] id: CL:0004215 name: type 5a cone bipolar cell namespace: cell def: "A type 5 cone bipolar cell with narrowly stratified post synaptic terminals." [] subset: cellxgene_subset subset: human_subset subset: mouse_subset is_a: CL:0000757 ! type 5 cone bipolar cell (sensu Mus) property_value: terms:contributor "https://orcid.org/0000-0001-7258-9596" xsd:string property_value: terms:contributor "https://orcid.org/0000-0002-5260-9315" xsd:string [Term] id: CL:0004216 name: type 5b cone bipolar cell namespace: cell def: "A type 5 cone bipolar cell with diffuse axonal branches." [] subset: cellxgene_subset subset: human_subset subset: mouse_subset is_a: CL:0000757 ! type 5 cone bipolar cell (sensu Mus) property_value: terms:contributor "https://orcid.org/0000-0001-7258-9596" xsd:string property_value: terms:contributor "https://orcid.org/0000-0002-5260-9315" xsd:string [Term] id: CL:0004217 name: H1 horizontal cell namespace: cell def: "A horizontal cell with a large cell body, thick dendrites, and a large dendritic arbor." [PMID:8571130] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "A Horizontal Cell" EXACT [] synonym: "H1" RELATED OMO:0003000 [doi:10.1038/s41598-020-66092-9] is_a: CL:0000745 ! retina horizontal cell relationship: CL:4030045 GO:0030424 ! lacks_part axon property_value: terms:contributor "https://orcid.org/0000-0001-7258-9596" xsd:string property_value: terms:contributor "https://orcid.org/0000-0002-5260-9315" xsd:string [Term] id: CL:0004218 name: H2 horizontal cell namespace: cell def: "A horizontal cell with a small cell body, thin dendrites, and small dendritic arbor." [PMID:8571130] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "B Horizontal Cell" EXACT [] synonym: "H2" RELATED OMO:0003000 [doi:10.1038/s41598-020-66092-9] is_a: CL:0000745 ! retina horizontal cell relationship: RO:0002120 GO:0044316 ! synapsed to cone cell pedicle property_value: terms:contributor "https://orcid.org/0000-0001-7258-9596" xsd:string property_value: terms:contributor "https://orcid.org/0000-0002-5260-9315" xsd:string [Term] id: CL:0004219 name: A2 amacrine cell namespace: cell def: "A bistratifed retinal amacrine cell with a small dendritic field, dendrite stratification in S1-S2, and a second dendrite stratification in S5. This cell type releases the neurotransmitter glycine." [PMID:24246263, PMID:9620701] subset: cellxgene_subset subset: human_subset subset: mouse_subset is_a: CL:0004250 ! bistratified retinal amacrine cell is_a: CL:0004251 ! narrow field retinal amacrine cell is_a: CL:4030028 ! glycinergic amacrine cell relationship: RO:0013001 UBERON:0008926 ! has synaptic IO in region sublaminar layer S5 relationship: RO:0013001 UBERON:0008927 ! has synaptic IO in region sublaminar layers S1 or S2 property_value: terms:contributor "https://orcid.org/0000-0001-7258-9596" xsd:string property_value: terms:contributor "https://orcid.org/0000-0002-5260-9315" xsd:string [Term] id: CL:0004220 name: flag amacrine cell namespace: cell def: "An amacrine cell with a small, asymteric dendritic field." [PMID:9620701] subset: human_subset subset: mouse_subset is_a: CL:0004251 ! narrow field retinal amacrine cell property_value: terms:contributor "https://orcid.org/0000-0001-7258-9596" xsd:string property_value: terms:contributor "https://orcid.org/0000-0002-5260-9315" xsd:string [Term] id: CL:0004221 name: flag A amacrine cell namespace: cell def: "A flag amacrine cell with post-synaptic terminals in S2 and S3. This cell type releases the neurotransmitter glycine." [PMID:24246263, PMID:9620701] subset: human_subset subset: mouse_subset is_a: CL:0004220 ! flag amacrine cell is_a: CL:4030028 ! glycinergic amacrine cell relationship: RO:0013001 UBERON:0008923 ! has synaptic IO in region sublaminar layer S2 relationship: RO:0013001 UBERON:0008924 ! has synaptic IO in region sublaminar layer S3 property_value: terms:contributor "https://orcid.org/0000-0001-7258-9596" xsd:string property_value: terms:contributor "https://orcid.org/0000-0002-5260-9315" xsd:string [Term] id: CL:0004222 name: flag B amacrine cell namespace: cell def: "A flag amacrine cell with post-synaptic terminals in S3, S4, and S5. This cell type releases the neurotransmitter glycine." [PMID:24246263, PMID:9620701] subset: human_subset subset: mouse_subset is_a: CL:0004220 ! flag amacrine cell is_a: CL:4030028 ! glycinergic amacrine cell relationship: RO:0013001 UBERON:0008924 ! has synaptic IO in region sublaminar layer S3 relationship: RO:0013001 UBERON:0008925 ! has synaptic IO in region sublaminar layer S4 relationship: RO:0013001 UBERON:0008926 ! has synaptic IO in region sublaminar layer S5 property_value: terms:contributor "https://orcid.org/0000-0001-7258-9596" xsd:string property_value: terms:contributor "https://orcid.org/0000-0002-5260-9315" xsd:string [Term] id: CL:0004223 name: AB diffuse-1 amacrine cell namespace: cell def: "A amacrine cell with a small dendritic field and post-synaptic terminals in S1, S2, S3, and S4. AB diffuse-1 amacrine cells have a tent-shaped dendritic arbor and undulate dendrites." [PMID:9620701] subset: human_subset subset: mouse_subset is_a: CL:0004251 ! narrow field retinal amacrine cell relationship: RO:0013001 UBERON:0008922 ! has synaptic IO in region sublaminar layer S1 relationship: RO:0013001 UBERON:0008923 ! has synaptic IO in region sublaminar layer S2 relationship: RO:0013001 UBERON:0008924 ! has synaptic IO in region sublaminar layer S3 relationship: RO:0013001 UBERON:0008925 ! has synaptic IO in region sublaminar layer S4 property_value: terms:contributor "https://orcid.org/0000-0001-7258-9596" xsd:string property_value: terms:contributor "https://orcid.org/0000-0002-5260-9315" xsd:string [Term] id: CL:0004224 name: AB diffuse-2 amacrine cell namespace: cell def: "A broadly stratifying amacrine cell that has a small dendritic field and post-synaptic terminals in S2 and S3. This cell type releases the neurotransmitter glycine." [PMID:32032773, PMID:9620701] subset: human_subset subset: mouse_subset is_a: CL:0004251 ! narrow field retinal amacrine cell is_a: CL:4030028 ! glycinergic amacrine cell relationship: RO:0013001 UBERON:0008923 ! has synaptic IO in region sublaminar layer S2 relationship: RO:0013001 UBERON:0008924 ! has synaptic IO in region sublaminar layer S3 property_value: terms:contributor "https://orcid.org/0000-0001-7258-9596" xsd:string property_value: terms:contributor "https://orcid.org/0000-0002-5260-9315" xsd:string [Term] id: CL:0004225 name: spider amacrine cell namespace: cell def: "A broadly stratifying amacrine cell with a small dendritic field, straight dendrites and post-synaptic terminals in S1, S2, and S3." [PMID:9620701] subset: human_subset subset: mouse_subset is_a: CL:0004251 ! narrow field retinal amacrine cell relationship: RO:0013001 UBERON:0008922 ! has synaptic IO in region sublaminar layer S1 relationship: RO:0013001 UBERON:0008923 ! has synaptic IO in region sublaminar layer S2 relationship: RO:0013001 UBERON:0008924 ! has synaptic IO in region sublaminar layer S3 property_value: terms:contributor "https://orcid.org/0000-0001-7258-9596" xsd:string property_value: terms:contributor "https://orcid.org/0000-0002-5260-9315" xsd:string [Term] id: CL:0004226 name: monostratified amacrine cell namespace: cell def: "An amacrine cell with a small dendritic field with post-synaptic terminals in S3 and S4." [PMID:9620701] subset: human_subset subset: mouse_subset is_a: CL:0004246 ! monostratified cell is_a: CL:0004251 ! narrow field retinal amacrine cell intersection_of: CL:0004251 ! narrow field retinal amacrine cell intersection_of: RO:0000053 PATO:0070063 ! has characteristic monostratified dendrite cell morphology relationship: RO:0013001 UBERON:0008924 ! has synaptic IO in region sublaminar layer S3 relationship: RO:0013001 UBERON:0008925 ! has synaptic IO in region sublaminar layer S4 property_value: terms:contributor "https://orcid.org/0000-0001-7258-9596" xsd:string property_value: terms:contributor "https://orcid.org/0000-0002-5260-9315" xsd:string [Term] id: CL:0004227 name: flat bistratified amacrine cell namespace: cell def: "A bistratified amacrine cell with a small dendritic field. Flat bistratified amacrine cells have post-synaptic terminals both on the border of S1 and S2, and on the border of S3 and S4. This cell type releases the neurotransmitter glycine." [PMID:25630271, PMID:9620701] subset: human_subset subset: mouse_subset is_a: CL:0004250 ! bistratified retinal amacrine cell is_a: CL:0004251 ! narrow field retinal amacrine cell is_a: CL:4030028 ! glycinergic amacrine cell relationship: RO:0013001 UBERON:0009738 ! has synaptic IO in region border of sublaminar layers S1 and S2 relationship: RO:0013001 UBERON:0009739 ! has synaptic IO in region border of sublaminar layers S3 and S4 property_value: terms:contributor "https://orcid.org/0000-0001-7258-9596" xsd:string property_value: terms:contributor "https://orcid.org/0000-0002-5260-9315" xsd:string [Term] id: CL:0004228 name: broad diffuse amacrine cell namespace: cell def: "An amacrine cell with a small dendritic field that has post-synaptic terminals in S1, S2, S3, and S4." [PMID:9620701] subset: human_subset subset: mouse_subset is_a: CL:0004251 ! narrow field retinal amacrine cell relationship: RO:0013001 UBERON:0008922 ! has synaptic IO in region sublaminar layer S1 relationship: RO:0013001 UBERON:0008923 ! has synaptic IO in region sublaminar layer S2 relationship: RO:0013001 UBERON:0008924 ! has synaptic IO in region sublaminar layer S3 relationship: RO:0013001 UBERON:0008925 ! has synaptic IO in region sublaminar layer S4 property_value: terms:contributor "https://orcid.org/0000-0001-7258-9596" xsd:string property_value: terms:contributor "https://orcid.org/0000-0002-5260-9315" xsd:string [Term] id: CL:0004229 name: A2-like amacrine cell namespace: cell def: "A bistratified amacrine cell with a small dendritic field that has dendrite stratification in S2, and in S3 and S4." [PMID:9620701] subset: human_subset subset: mouse_subset is_a: CL:0004250 ! bistratified retinal amacrine cell is_a: CL:0004251 ! narrow field retinal amacrine cell relationship: RO:0013001 UBERON:0008923 ! has synaptic IO in region sublaminar layer S2 relationship: RO:0013001 UBERON:0009731 ! has synaptic IO in region sublaminar layers S3 or S4 property_value: terms:contributor "https://orcid.org/0000-0001-7258-9596" xsd:string property_value: terms:contributor "https://orcid.org/0000-0002-5260-9315" xsd:string [Term] id: CL:0004230 name: diffuse bistratified amacrine cell namespace: cell def: "A bistratified amacrine cell with a small dendritic field that has post-synaptic terminals in S1 and the border of S1-S2, and termination of a second arbor within the border of S2-S3 and S3." [PMID:9620701] subset: human_subset subset: mouse_subset is_a: CL:0004250 ! bistratified retinal amacrine cell is_a: CL:0004251 ! narrow field retinal amacrine cell relationship: RO:0013001 UBERON:0008922 ! has synaptic IO in region sublaminar layer S1 relationship: RO:0013001 UBERON:0008924 ! has synaptic IO in region sublaminar layer S3 relationship: RO:0013001 UBERON:0009738 ! has synaptic IO in region border of sublaminar layers S1 and S2 relationship: RO:0013001 UBERON:0009852 ! has synaptic IO in region border of sublaminar layers S2 and S3 property_value: terms:contributor "https://orcid.org/0000-0001-7258-9596" xsd:string property_value: terms:contributor "https://orcid.org/0000-0002-5260-9315" xsd:string [Term] id: CL:0004231 name: recurving diffuse amacrine cell namespace: cell def: "A broadly stratifying amacrine cell with a small dendritic field and a complex dendritic arbor. Recurving diffuse amacrine cells have post-synaptic terminals in S2, S3, and S4." [PMID:9620701] subset: human_subset subset: mouse_subset is_a: CL:0004251 ! narrow field retinal amacrine cell relationship: RO:0013001 UBERON:0008923 ! has synaptic IO in region sublaminar layer S2 relationship: RO:0013001 UBERON:0008924 ! has synaptic IO in region sublaminar layer S3 relationship: RO:0013001 UBERON:0008925 ! has synaptic IO in region sublaminar layer S4 property_value: terms:contributor "https://orcid.org/0000-0001-7258-9596" xsd:string property_value: terms:contributor "https://orcid.org/0000-0002-5260-9315" xsd:string [Term] id: CL:0004232 name: starburst amacrine cell namespace: cell def: "An amacrine cell with a flat dendritic arbor and a medium dendritic field. Starburst amacrine cells have post-synaptic terminals in S2. This cell type releases the neurotransmitters gamma-aminobutyric acid (GABA) and acetylcholine." [PMID:32032773, PMID:9620701] subset: cellxgene_subset subset: human_subset subset: mouse_subset is_a: CL:0008061 ! GABA-Chol neuron is_a: CL:4030027 ! GABAergic amacrine cell relationship: RO:0013001 UBERON:0008923 ! has synaptic IO in region sublaminar layer S2 property_value: terms:contributor "https://orcid.org/0000-0001-7258-9596" xsd:string property_value: terms:contributor "https://orcid.org/0000-0002-5260-9315" xsd:string [Term] id: CL:0004233 name: DAPI-3 amacrine cell namespace: cell def: "An amacrine cell with a medium dendritic field and post-synaptic terminals that stratify at S2, with a second stratification that occurs in S3 and S4. This cell type releases the neurotransmitter glycine." [PMID:9194315] subset: human_subset subset: mouse_subset is_a: CL:0004250 ! bistratified retinal amacrine cell is_a: CL:0004252 ! medium field retinal amacrine cell is_a: CL:4030028 ! glycinergic amacrine cell relationship: RO:0013001 UBERON:0008923 ! has synaptic IO in region sublaminar layer S2 relationship: RO:0013001 UBERON:0009731 ! has synaptic IO in region sublaminar layers S3 or S4 property_value: terms:contributor "https://orcid.org/0000-0001-7258-9596" xsd:string property_value: terms:contributor "https://orcid.org/0000-0002-5260-9315" xsd:string [Term] id: CL:0004234 name: diffuse multistratified amacrine cell namespace: cell def: "An amacrine cell with a medium dendritic field and post-synaptic terminals in S2, and in S3-S4." [PMID:9620701] subset: human_subset subset: mouse_subset is_a: CL:0004252 ! medium field retinal amacrine cell relationship: RO:0013001 UBERON:0008923 ! has synaptic IO in region sublaminar layer S2 relationship: RO:0013001 UBERON:0009731 ! has synaptic IO in region sublaminar layers S3 or S4 property_value: terms:contributor "https://orcid.org/0000-0001-7258-9596" xsd:string property_value: terms:contributor "https://orcid.org/0000-0002-5260-9315" xsd:string [Term] id: CL:0004235 name: AB broad diffuse-1 amacrine cell namespace: cell def: "An amacrine cell with a medium dendritic field and post-synaptic terminals in S2 and S3. This cell type releases the neurotransmitter gamma-aminobutyric acid (GABA)." [PMID:32032773, PMID:9620701] subset: human_subset subset: mouse_subset is_a: CL:0004252 ! medium field retinal amacrine cell is_a: CL:4030027 ! GABAergic amacrine cell relationship: RO:0013001 UBERON:0008923 ! has synaptic IO in region sublaminar layer S2 relationship: RO:0013001 UBERON:0008924 ! has synaptic IO in region sublaminar layer S3 property_value: terms:contributor "https://orcid.org/0000-0001-7258-9596" xsd:string property_value: terms:contributor "https://orcid.org/0000-0002-5260-9315" xsd:string [Term] id: CL:0004236 name: AB broad diffuse-2 amacrine cell namespace: cell def: "An amacrine cell with a medium dendritic field and post-synaptic terminals in S2, S3, and S4. This cell type releases the neurotransmitter gamma-aminobutyric acid (GABA)." [PMID:32032773, PMID:9620701] subset: human_subset subset: mouse_subset is_a: CL:0004252 ! medium field retinal amacrine cell is_a: CL:4030027 ! GABAergic amacrine cell relationship: RO:0013001 UBERON:0008923 ! has synaptic IO in region sublaminar layer S2 relationship: RO:0013001 UBERON:0008924 ! has synaptic IO in region sublaminar layer S3 relationship: RO:0013001 UBERON:0008925 ! has synaptic IO in region sublaminar layer S4 property_value: terms:contributor "https://orcid.org/0000-0001-7258-9596" xsd:string property_value: terms:contributor "https://orcid.org/0000-0002-5260-9315" xsd:string [Term] id: CL:0004237 name: fountain amacrine cell namespace: cell def: "A retinal amacrine cell with a medium dendritic field and post-synaptic terminals in S1, S2, S3, and S4. This cell type releases the neurotransmitter gamma-aminobutyric acid (GABA)." [PMID:10614594, PMID:9620701] subset: human_subset subset: mouse_subset is_a: CL:0004252 ! medium field retinal amacrine cell is_a: CL:4030027 ! GABAergic amacrine cell relationship: RO:0013001 UBERON:0008922 ! has synaptic IO in region sublaminar layer S1 relationship: RO:0013001 UBERON:0008923 ! has synaptic IO in region sublaminar layer S2 relationship: RO:0013001 UBERON:0008924 ! has synaptic IO in region sublaminar layer S3 relationship: RO:0013001 UBERON:0008925 ! has synaptic IO in region sublaminar layer S4 property_value: terms:contributor "https://orcid.org/0000-0001-7258-9596" xsd:string property_value: terms:contributor "https://orcid.org/0000-0002-5260-9315" xsd:string [Term] id: CL:0004238 name: asymmetric bistratified amacrine cell namespace: cell def: "A bistratified amacrine cell with a medium dendritic field, a flat and sparse dendritic arbor, and post-synaptic terminals at the intersections of S1 and S2, and S3 and S4." [PMID:9620701] subset: human_subset subset: mouse_subset is_a: CL:0004250 ! bistratified retinal amacrine cell is_a: CL:0004252 ! medium field retinal amacrine cell relationship: RO:0013001 UBERON:0009738 ! has synaptic IO in region border of sublaminar layers S1 and S2 relationship: RO:0013001 UBERON:0009739 ! has synaptic IO in region border of sublaminar layers S3 and S4 property_value: terms:contributor "https://orcid.org/0000-0001-7258-9596" xsd:string property_value: terms:contributor "https://orcid.org/0000-0002-5260-9315" xsd:string [Term] id: CL:0004239 name: wavy bistratified amacrine cell namespace: cell def: "A bistratified amacrine cell with a medium dendritic field and post-synaptic terminals in S1-S2, and S4." [PMID:9620701] subset: human_subset subset: mouse_subset is_a: CL:0004250 ! bistratified retinal amacrine cell is_a: CL:0004252 ! medium field retinal amacrine cell relationship: RO:0013001 UBERON:0008922 ! has synaptic IO in region sublaminar layer S1 relationship: RO:0013001 UBERON:0008923 ! has synaptic IO in region sublaminar layer S2 relationship: RO:0013001 UBERON:0008925 ! has synaptic IO in region sublaminar layer S4 property_value: terms:contributor "https://orcid.org/0000-0001-7258-9596" xsd:string property_value: terms:contributor "https://orcid.org/0000-0002-5260-9315" xsd:string [Term] id: CL:0004240 name: WF1 amacrine cell namespace: cell def: "An amacrine cell with a wide dendritic field, dendrites in S1, and post-synaptic terminals in S1." [PMID:9620701] subset: human_subset subset: mouse_subset is_a: CL:0004253 ! wide field retinal amacrine cell relationship: RO:0013001 UBERON:0008922 ! has synaptic IO in region sublaminar layer S1 property_value: terms:contributor "https://orcid.org/0000-0001-7258-9596" xsd:string property_value: terms:contributor "https://orcid.org/0000-0002-5260-9315" xsd:string [Term] id: CL:0004241 name: WF2 amacrine cell namespace: cell def: "An amacrine cell with a wide dendritic field, dendrites in S2, and post-synaptic terminals in S1." [PMID:9620701] subset: human_subset subset: mouse_subset is_a: CL:0004253 ! wide field retinal amacrine cell relationship: RO:0013001 UBERON:0008922 ! has synaptic IO in region sublaminar layer S1 property_value: terms:contributor "https://orcid.org/0000-0001-7258-9596" xsd:string property_value: terms:contributor "https://orcid.org/0000-0002-5260-9315" xsd:string [Term] id: CL:0004242 name: WF3-1 amacrine cell namespace: cell def: "An amacrine cell with a wide dendritic field, dendrites in S3, and post-synaptic terminals in S3. Dendrites of this cell type are straight and minimally branched." [PMID:9620701] subset: human_subset subset: mouse_subset is_a: CL:0004253 ! wide field retinal amacrine cell relationship: RO:0013001 UBERON:0008924 ! has synaptic IO in region sublaminar layer S3 property_value: terms:contributor "https://orcid.org/0000-0001-7258-9596" xsd:string property_value: terms:contributor "https://orcid.org/0000-0002-5260-9315" xsd:string [Term] id: CL:0004243 name: WF3-2 amacrine cell namespace: cell def: "An amacrine cell with a wild dendritic field, dendrites in S3, and post-synaptic terminals in S3. Dendrites have spikes, cross over each other, and cover a larger volume than dendrties of W3-1 retinal amacrine cells." [PMID:9620701] subset: human_subset subset: mouse_subset is_a: CL:0004253 ! wide field retinal amacrine cell relationship: RO:0013001 UBERON:0008924 ! has synaptic IO in region sublaminar layer S3 property_value: terms:contributor "https://orcid.org/0000-0001-7258-9596" xsd:string property_value: terms:contributor "https://orcid.org/0000-0002-5260-9315" xsd:string [Term] id: CL:0004244 name: WF4 amacrine cell namespace: cell def: "An amacrine cell with a wide dendritic field, dendrites in S4, and post-synaptic terminals in S4." [PMID:9620701] subset: human_subset subset: mouse_subset is_a: CL:0004253 ! wide field retinal amacrine cell relationship: RO:0013001 UBERON:0008925 ! has synaptic IO in region sublaminar layer S4 property_value: terms:contributor "https://orcid.org/0000-0001-7258-9596" xsd:string property_value: terms:contributor "https://orcid.org/0000-0002-5260-9315" xsd:string [Term] id: CL:0004245 name: indoleamine-accumulating amacrine cell namespace: cell def: "An amacrine cell with a wide dendritic field and post-synaptic terminals in S5. This cell type releases the neurotransmitters gamma-aminobutyric acid (GABA) and serotonin." [PMID:12486181, PMID:9620701] subset: human_subset subset: mouse_subset is_a: CL:0000850 ! serotonergic neuron is_a: CL:0004253 ! wide field retinal amacrine cell is_a: CL:4030027 ! GABAergic amacrine cell relationship: RO:0013001 UBERON:0008926 ! has synaptic IO in region sublaminar layer S5 property_value: terms:contributor "https://orcid.org/0000-0001-7258-9596" xsd:string property_value: terms:contributor "https://orcid.org/0000-0002-5260-9315" xsd:string [Term] id: CL:0004246 name: monostratified cell namespace: cell def: "A central nervous system neuron that stratifies at one and only one location." [PMID:9620701] subset: human_subset subset: mouse_subset is_a: CL:2000029 ! central nervous system neuron intersection_of: CL:0000540 ! neuron intersection_of: RO:0000053 PATO:0070063 ! has characteristic monostratified dendrite cell morphology intersection_of: RO:0002100 UBERON:0001017 ! has soma location central nervous system relationship: RO:0000053 PATO:0070063 ! has characteristic monostratified dendrite cell morphology property_value: terms:contributor "https://orcid.org/0000-0001-7258-9596" xsd:string property_value: terms:contributor "https://orcid.org/0000-0002-5260-9315" xsd:string [Term] id: CL:0004247 name: bistratified cell namespace: cell def: "A neuron that stratifies dendrites at two and only two locations." [https://orcid.org/0000-0002-5260-9315, PMID:9620701] subset: human_subset subset: mouse_subset is_a: CL:2000029 ! central nervous system neuron intersection_of: CL:0000540 ! neuron intersection_of: RO:0000053 PATO:0070062 ! has characteristic bistratified dendrite cell morphology relationship: RO:0000053 PATO:0070062 ! has characteristic bistratified dendrite cell morphology property_value: terms:contributor "https://orcid.org/0000-0001-7258-9596" xsd:string [Term] id: CL:0004250 name: bistratified retinal amacrine cell namespace: cell def: "An amicrine that stratifies dendrites at two and only two locations." [PMID:9620701] subset: human_subset subset: mouse_subset is_a: CL:0000561 ! amacrine cell is_a: CL:0004247 ! bistratified cell intersection_of: CL:0000561 ! amacrine cell intersection_of: RO:0000053 PATO:0070062 ! has characteristic bistratified dendrite cell morphology property_value: terms:contributor "https://orcid.org/0000-0001-7258-9596" xsd:string property_value: terms:contributor "https://orcid.org/0000-0002-5260-9315" xsd:string [Term] id: CL:0004251 name: narrow field retinal amacrine cell namespace: cell def: "An amicrine that has a narrow dendritic field." [PMID:9620701] subset: human_subset subset: mouse_subset is_a: CL:0000561 ! amacrine cell property_value: terms:contributor "https://orcid.org/0000-0001-7258-9596" xsd:string property_value: terms:contributor "https://orcid.org/0000-0002-5260-9315" xsd:string [Term] id: CL:0004252 name: medium field retinal amacrine cell namespace: cell def: "An amicrine that has a medium dendritic field." [PMID:9620701] subset: human_subset subset: mouse_subset is_a: CL:0000561 ! amacrine cell property_value: terms:contributor "https://orcid.org/0000-0001-7258-9596" xsd:string property_value: terms:contributor "https://orcid.org/0000-0002-5260-9315" xsd:string [Term] id: CL:0004253 name: wide field retinal amacrine cell namespace: cell def: "An amicrine that has a wide dendritic field." [PMID:9620701] subset: human_subset subset: mouse_subset is_a: CL:0000561 ! amacrine cell property_value: terms:contributor "https://orcid.org/0000-0001-7258-9596" xsd:string property_value: terms:contributor "https://orcid.org/0000-0002-5260-9315" xsd:string [Term] id: CL:0005000 name: spinal cord interneuron def: "A CNS interneuron located in the spinal cord." [CL:CVS] comment: Is_a interneuron, part_of UBERON:0002240. subset: human_subset subset: mouse_subset xref: ZFA:0000778 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000099 {is_inferred="true"} ! interneuron intersection_of: CL:0000099 ! interneuron intersection_of: RO:0002100 UBERON:0002240 ! has soma location spinal cord relationship: RO:0002100 UBERON:0002240 ! has soma location spinal cord property_value: skos:prefLabel "spinal cord interneuron" xsd:string [Term] id: CL:0005001 name: iridoblast def: "A non-terminally differentiated cell that originates from the neural crest and differentiates into an iridophore." [CL:CVS] comment: Derived from UBERON:0002342 neural crest. subset: human_subset subset: mouse_subset xref: ZFA:0005328 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0011026 ! progenitor cell relationship: RO:0002202 CL:0000333 ! develops from migratory neural crest cell [Term] id: CL:0005002 name: xanthoblast def: "A non-terminally differentiated cell that differentiates into a xanthophore." [CL:CVS] subset: human_subset subset: mouse_subset xref: ZFA:0005245 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0011026 ! progenitor cell relationship: RO:0002202 CL:0000333 ! develops from migratory neural crest cell [Term] id: CL:0005003 name: leucoblast def: "A non-terminally differentiated cell that originates from the neural crest and differentiates into a leucophore." [CL:CVS] subset: human_subset subset: mouse_subset xref: ZFA:0005329 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0011026 ! progenitor cell relationship: RO:0002202 CL:0000333 ! develops from migratory neural crest cell [Term] id: CL:0005004 name: pigment erythroblast def: "A non-terminally differentiated cell that originates from the neural crest and differentiates into an erythrophore." [CL:CVS] subset: human_subset subset: mouse_subset xref: ZFA:0005331 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0011026 ! progenitor cell relationship: RO:0002202 CL:0000333 ! develops from migratory neural crest cell [Term] id: CL:0005005 name: cyanoblast def: "A non-terminally differentiated cell that originates from the neural crest and differentiates into a cyanophore." [CL:CVS] subset: human_subset subset: mouse_subset xref: ZFA:0005332 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0011026 ! progenitor cell relationship: RO:0002202 CL:0000333 ! develops from migratory neural crest cell [Term] id: CL:0005006 name: ionocyte def: "Specialized epithelial cells involved in the maintenance of osmotic homeostasis. They are characterized by abundant mitochondria and ion transporters. In amniotes, they are present in the renal system. In freshwater fish, ionocytes in the skin and gills help maintain osmotic homeostasis by absorbing salt from the external environment." [PMID:17555741, PMID:19268451] subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset xref: ZFA:0005323 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000066 ! epithelial cell property_value: RO:0002175 NCBITaxon:9606 property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0005006" xsd:string {name="ionocyte on CELLxGENE CellGuide"} property_value: terms:description "Ionocytes are specialized cells predominantly found in the mammalian respiratory and renal systems as well as in the gills, skin, and intestinal tract of fish. These cells play crucial roles in maintaining ion and acid-base homeostasis. Ionocytes demonstrate remarkable plasticity and are able to adapt themselves in response to changes in environmental conditions such as pH, salinity, ion concentration, and temperature.\nThese cells work by selectively absorbing specific ions from the environment, thus maintaining the body's internal ionic balance. The most commonly absorbed ions include sodium (Na+), chloride (Cl-), calcium (Ca2+), and hydrogen (H+). Moreover, ionocytes contribute to acid-base regulation. In response to acidosis or alkalosis, ionocytes can either excrete or retain hydrogen (H+) and bicarbonate (HCO3-) ions to readjust the blood pH. Further, experimental evidence suggests a functional complexity of ionocytes, implying diverse roles beyond ion regulation. Recent research highlights ionocytes' involvement in ammonia excretion and the regulation of extracellular fluid volume, highlighting their contribution to the overall homeostatic process.\nMalfunctioning ionocytes have been implicated in various diseases, including cystic fibrosis which is caused by mutations in the chloride channel CFTR, an ionocyte marker.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1016/j.jcf.2019.09.010", xref="DOI:10.1038/s41586-018-0393-7", xref="DOI:10.1038/s41598-023-30603-1", xref="DOI:10.1146/annurev-pathol-042420-094031", xref="DOI:10.3389/fmars.2020.00709"} [Term] id: CL:0005007 name: Kolmer-Agduhr neuron def: "Kolmer-Agduhr neurons are ciliated GABAergic neurons that contact the central canal of the spinal cord and have ipsilateral ascending axons." [PMID:18680739] subset: human_subset subset: mouse_subset synonym: "KA cell" EXACT [] synonym: "KA interneuron" EXACT [PMID:15539490] synonym: "KA neuron" EXACT [PMID:9634146] synonym: "Kolmer-Agduhr cell" EXACT [] xref: ZFA:0005240 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0005000 ! spinal cord interneuron is_a: CL:0011005 ! GABAergic interneuron [Term] id: CL:0005008 name: macular hair cell def: "An auditory hair cell located in the macula that is sensitive to auditory stimuli." [GO:cvs] subset: human_subset subset: mouse_subset is_a: CL:0000202 ! auditory hair cell is_a: CL:0002374 ! ear hair cell intersection_of: CL:0000202 ! auditory hair cell intersection_of: BFO:0000050 UBERON:0000054 ! part of macula relationship: BFO:0000050 UBERON:0000054 ! part of macula [Term] id: CL:0005009 name: renal principal cell def: "A cuboidal epithelial cell of the kidney which regulates sodium and potassium balance. The activity of sodium and potassium channels on the apical membrane of the cell is regulated by aldosterone and vasopressin. In mammals this cell type is located in the renal collecting duct system." [CL:CVS] subset: cellxgene_subset subset: human_subset subset: mouse_subset xref: ZFA:0005322 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000075 ! columnar/cuboidal epithelial cell is_a: CL:0002518 ! kidney epithelial cell property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0005009" xsd:string {name="renal principal cell on CELLxGENE CellGuide"} property_value: terms:description "Renal principal cells are the major cell type in the initial collecting tubule and the cortical and outer medullary collecting ducts, as well as the connecting tubule, in the nephrons of the kidneys.\nA key function of renal principal cells is the regulation of water balance in the body. These cells express aquaporin-2 (AQP2) water channels, which facilitate the reabsorption of water from the fluid within the renal tubule lumen back into the blood. The translocation of AQP2 to the cell membrane is controlled by the hormone vasopressin: In response to high vasopressin levels, AQP2 moves to the cell membrane, allowing water to pass through effectively and be reabsorbed, therefore concentrating the urine. Conversely, in low vasopressin conditions, AQP2 is removed from the membrane, reducing water reabsorption and diluting the urine. \nRenal principal cells are also involved in the regulation of sodium and potassium levels in the body. They have sodium channels (ENaC) in their luminal membranes which permit the reabsorption of sodium ions from the tubule fluid back into the blood, resulting in a net reabsorption of sodium ions into the systemic circulation. This process is controlled, in part, by the hormone aldosterone. Additionally, renal principal cells contain potassium channels that facilitate the secretion of potassium ions into the urine. The activities of these channels, in coordination with other cell types in the nephron, are critical for maintaining electrolyte balance and overall body homeostasis.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1016/j.krcp.2013.07.005", xref="DOI:10.2215/CJN.05760513", xref="DOI:10.2215/CJN.08580813"} [Term] id: CL:0005010 name: renal intercalated cell def: "A cuboidal epithelial cell of the kidney that regulates acid/base balance." [CL:CVS] comment: Intercalated cells are also called “mitochondria-rich cells”, reflecting the high levels of round mitochondria at their apical pole, or in their cytoplasm, a distribution that is quite different from that of other kidney tubule cells, which accumulated mitochondria around the basolateral membrane. These cells also have numerous irregular apical microvilli compared with the surrounding segment-specific cells. Intercalated cells lack a central cilium, at least in the cortex, which also differentiates them from the adjacent principal cells. {xref="PMID:25632105"} subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "intercalated cell" EXACT [] xref: FMA:86560 xref: ZFA:0009375 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000075 ! columnar/cuboidal epithelial cell is_a: CL:0002078 ! meso-epithelial cell is_a: CL:1000449 ! epithelial cell of nephron property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0005010" xsd:string {name="renal intercalated cell on CELLxGENE CellGuide"} property_value: terms:description "Renal intercalated cells are specialized cells located in the collecting duct system of the kidneys. The primary role of intercalated cells is to reabsorb bicarbonate ions and secrete hydrogen ions, thereby maintaining the acid-base homeostasis in the blood. They comprise two main subtypes primarily distinguished by their functional and morphological attributes: alpha and beta intercalated cells.\nAlpha intercalated cells are more predominant when the body is in a state of acidosis, a condition characterized by an increased acidity of the blood. These cells are specialized in secreting excessive hydrogen ions into the urine through a mechanism involving vacuolar H+-ATPase and H+/K+-ATPase pumps on their apical membranes. They simultaneously reabsorb bicarbonate ions from the tubular fluid and return them to the bloodstream via mechanisms involving carbonic anhydrase II and bicarbonate/chloride exchangers on the basolateral membrane. This dual process helps to increase blood pH towards normal levels.\nWhen the body is in a state of alkalosis, a condition characterized by lowered levels of hydrogen ions in the blood, beta intercalated cells are more predominant. They primarily reabsorb hydrogen ions from the tubular fluid through vacuolar H+-ATPase and H+/K+-ATPase pumps on their basolateral membranes, while secreting bicarbonate ions into the urine via pendrin, a bicarbonate/chloride exchanger in the apical membrane. These mechanisms work together to decrease blood pH towards normal levels. \nIn summary, renal intercalated cells play a critical role in the delicate balance of the body’s pH, safeguarding the body from potential harm caused by acidemia or alkalemia.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1152/ajprenal.2000.279.1.F195", xref="DOI:10.1161/HYPERTENSIONAHA.121.16492", xref="DOI:10.1681/ASN.V1011", xref="DOI:10.2215/CJN.08880914"} [Term] id: CL:0005011 name: renal alpha-intercalated cell def: "A cuboidal epithelial cell of the kidney which secretes acid and reabsorbs base to regulate acid/base balance." [CL:CVS] comment: Type A intercalated cells are the more abundant type of intercalated cell in the outer stripe of the outer medulla in most mammalian species. {xref="PMID:25632105"} subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "type A intercalated cell" EXACT [PMID:25632105] synonym: "type A-IC" EXACT [PMID:25632105] xref: ZFA:0009376 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0005010 ! renal intercalated cell relationship: RO:0002215 GO:0046717 ! capable of acid secretion property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0005011" xsd:string {name="renal alpha-intercalated cell on CELLxGENE CellGuide"} property_value: terms:description "Renal alpha-intercalated cells are located within the connecting tubules and collecting ducts of the kidneys, which are components of the kidney's complex nephron system. Along with beta-intercalated cells, they play a critical role in the body’s acid-base balance. \nRenal alpha-intercalated cells contain an abundance of proton pumps and enzymes like carbonic anhydrase, which aid in the transport of hydrogen ions for secretion in the urine. The bicarbonate/chloride transporters on their apical membrane meanwhile take up bicarbonate ions from the urine and supply them back into the blood. Through this mechanism, these cells contribute significantly to the neutrality of blood pH, and dysfunction of renal alpha-intercalated cells often leads to distal renal tubular acidosis, a condition resulting in acidic blood and alkaline urine.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1016/j.semnephrol.2019.04.005", xref="DOI:10.1152/physiol.00008.2011", xref="DOI:10.1172/JCI63492", xref="DOI:10.3390/diseases2020071"} [Term] id: CL:0005012 name: multiciliated epithelial cell def: "A columnar/cuboidal epithelial cell with multiple motile cilia on its apical surface. These cells facilitate the movement of liquids such as mucus or cerebrospinal fluid across the epithelial surface." [CL:CVS, PMID:28400610, PMID:30422572, PMID:38032388] comment: While the term 'multi-ciliated epithelial cell' refers to cells with multiple motile cilia, there are exceptions where epithelial cells may have multiple non-motile cilia. Examples include olfactory sensory neurons, which have non-motile cilia for sensory detection, and choroid plexus epithelial cells, which possess multiple non-motile cilia with transient motility during development. Multiciliated cells are essential for human health, and their dysfunction can lead to various diseases known as ciliopathies, such as primary ciliary dyskinesia. This condition affects the respiratory system, brain ventricles, and reproductive system, leading to chronic respiratory infections, hydrocephalus, and infertility {xref="PMID:22118931", xref="PMID:23959957", xref="PMID:26378583", xref="PMID:25729351"} subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "MCC" RELATED OMO:0003000 [] synonym: "multi-ciliated cell" BROAD [] synonym: "multi-ciliated epithelial cell" EXACT [] synonym: "multiciliated cell" BROAD [] synonym: "multiciliated epithelial cell" EXACT [] xref: ZFA:0005242 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000067 ! ciliated epithelial cell is_a: CL:0000075 ! columnar/cuboidal epithelial cell intersection_of: CL:0000075 ! columnar/cuboidal epithelial cell intersection_of: BFO:0000051 GO:0031514 ! has part motile cilium intersection_of: RO:0000053 PATO:0010007 ! has characteristic multiciliated relationship: BFO:0000051 GO:0031514 ! has part motile cilium relationship: RO:0000053 PATO:0010007 ! has characteristic multiciliated property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0005012" xsd:string {name="multiciliated epithelial cell on CELLxGENE CellGuide"} property_value: terms:description "The multi-ciliated epithelial cell are terminally differentiated epithelia that line brain ventricles, the respiratory tract and parts of the female and male reproductive organs in animals, playing critical roles in the maintenance of homeostasis through ciliary motion. They are characterized by the presence of hundreds of motile cilia, hair-like microtubule-based organelles that beat in a coordinated fashion to direct fluid flow over the cell surface.\nMulti-ciliated epithelial cells have fundamental roles in the proper functioning of many organ systems. In the respiratory system, they line the airways and orchestrate the coordinated movement of mucus, effectively clearing the airways of inhaled particles and pathogens. These cells are also vital in the ventricular system of the brain where they facilitate cerebrospinal fluid circulation, thus contributing to the maintenance of the brain's microenvironment. In the fallopian tube, multi-ciliated epithelial cells aid in the transport of oocytes from the ovary to the uterus, a process crucial to reproduction.\nThe formation and function of multi-ciliated epithelial cells is a highly regulated process that involves several stages of development including cell specification, centriole multiplication, and ciliogenesis. Any disruption in these processes can result in dysfunctional or decreased numbers of cilia, which can lead to a myriad of health issues, ranging from chronic respiratory infections to infertility.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1016/j.cub.2014.08.047", xref="DOI:10.1038/nrm.2017.21", xref="DOI:10.1101/cshperspect.a028233"} [Term] id: CL:0005013 name: single ciliated epithelial cell def: "A ciliated epithelial cell with a single cilium." [CL:CVS] subset: human_subset subset: mouse_subset xref: ZFA:0005243 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000067 ! ciliated epithelial cell [Term] id: CL:0005014 name: auditory epithelial supporting cell def: "A non-sensory cell that extends from the basement membrane to the apical surface of the auditory epithelium and provides support for auditory hair cells." [CL:CVS, GOC:tfm] subset: human_subset subset: mouse_subset synonym: "auditory epithelial support cell" EXACT [] xref: ZFA:0005244 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000630 ! supporting cell is_a: CL:0000710 ! neurecto-epithelial cell is_a: CL:0002491 ! auditory epithelial cell [Term] id: CL:0005015 name: inner phalangeal cell def: "An auditory epithelial support cell that surrounds the nerve fibers and synapses of the auditory inner hair cells." [CL:CVS] subset: human_subset subset: mouse_subset xref: FMA:79801 is_a: CL:0002165 ! phalangeal cell [Term] id: CL:0005016 name: obsolete apical cell def: "Obsolete. Use PO:0030007 from Plant Ontology instead. The apical cell is the upper cell formed after the first division of a plant zygote." [TAIR:TB] is_obsolete: true replaced_by: PO:0030007 [Term] id: CL:0005017 name: obsolete plant basal cell def: "Obsolete. Use PO:0002002 from Plant Ontology instead. The lower cell formed after the first division of a plant zygote." [TAIR:TB] is_obsolete: true replaced_by: PO:0002002 [Term] id: CL:0005018 name: ghrelin secreting cell def: "A cell that secretes ghrelin, the peptide hormone that stimulates hunger." [CL:curator] subset: human_subset subset: mouse_subset xref: ZFA:0005599 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000167 ! peptide hormone secreting cell intersection_of: CL:0000151 ! secretory cell intersection_of: RO:0002215 GO:0036321 ! capable of ghrelin secretion relationship: RO:0002215 GO:0036321 ! capable of ghrelin secretion [Term] id: CL:0005019 name: pancreatic epsilon cell def: "Ghrelin secreting cells found in the endocrine pancreas." [PMID:14970313] comment: In mammals the endocrine pancreas is called the Islets of Langerhans. subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "pancreatic E cell" EXACT [] xref: ZFA:0005598 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0005018 ! ghrelin secreting cell is_a: CL:0008024 ! pancreatic endocrine cell intersection_of: CL:0008024 ! pancreatic endocrine cell intersection_of: RO:0002215 GO:0036321 ! capable of ghrelin secretion property_value: RO:0002175 NCBITaxon:9606 property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0005019" xsd:string {name="pancreatic epsilon cell on CELLxGENE CellGuide"} property_value: terms:description "Pancreatic epsilon cells are a specialized type of endocrine cell found in the islets of Langerhans, a region of the pancreas responsible for hormone production. These clusters of cells constitute only about 1% of the pancreatic islet cell population, making them a relatively small yet significant component of the pancreas. Pancreatic epsilon cells have a round or ovoid shape with occasional cytoplasmic extensions and are characterized by small and spherical granules. \nThe principal function of pancreatic epsilon cells involves the synthesis and release of the hormone ghrelin, a peptide hormone predominantly produced in the stomach; pancreatic epsilon cells are one of the few sites outside the gastrointestinal tract known to produce this hormone. Ghrelin has multiple vital roles, playing a significant part in generating hunger sensations, promoting fat storage, and influencing various metabolic processes. It also stimulates the release of Growth Hormone (GH) from the anterior pituitary gland.\nDuring fetal development, when they form a layer around the islet, epsilon cells are an important source of ghrelin, likely secreting the hormone into the circulation; their numbers decrease in adults. While research on pancreatic epsilon cells is still ongoing, these cells have been implicated in several disease states, most notably Type 2 diabetes and metabolic syndrome. The dysfunction or reduction in the number of pancreatic epsilon cells can lead to anomalies in ghrelin production, impacting overall metabolic homeostasis and glucose regulation.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1007/s00125-008-1238-y", xref="DOI:10.1152/physrev.00012.2004", xref="DOI:10.1210/en.2018-00833", xref="DOI:10.3389/fendo.2022.904004", xref="DOI:10.3390/ijms20081867"} [Term] id: CL:0005020 name: lymphangioblast def: "Lymphatic progenitor cells." [CL:CVS] comment: Usually express Prox1, or prox1b. subset: human_subset subset: mouse_subset xref: ZFA:0009393 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000048 {is_inferred="true"} ! multi fate stem cell is_a: CL:4033054 ! perivascular cell intersection_of: CL:0000048 ! multi fate stem cell intersection_of: RO:0002220 UBERON:0004536 ! adjacent to lymph vasculature relationship: RO:0002220 UBERON:0004536 ! adjacent to lymph vasculature property_value: terms:contributor https://orcid.org/0000-0002-2244-7917 creation_date: 2012-01-12T04:44:34Z [Term] id: CL:0005021 name: mesenchymal lymphangioblast def: "Mesenchymal derived lymphatic progenitor cells that give rise to the superficial lymphatics." [PMID:15624319, PMID:18430230] subset: cellxgene_subset subset: human_subset subset: mouse_subset xref: ZFA:0009394 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000134 ! mesenchymal stem cell is_a: CL:0005020 ! lymphangioblast property_value: terms:contributor https://orcid.org/0000-0002-2244-7917 creation_date: 2012-01-12T05:01:22Z [Term] id: CL:0005022 name: vascular lymphangioblast def: "Lymphatic progenitor cells, derived from the veins, that give rise to lymphatic endothelial cells." [CL:CVS] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "parachordal lymphangioblast" NARROW [] xref: ZFA:0009395 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0005020 {is_inferred="true"} ! lymphangioblast intersection_of: CL:0005020 ! lymphangioblast intersection_of: RO:0002220 UBERON:0001638 ! adjacent to vein relationship: RO:0002220 UBERON:0001638 ! adjacent to vein property_value: terms:contributor https://orcid.org/0000-0002-2244-7917 creation_date: 2012-01-12T05:21:09Z [Term] id: CL:0005023 name: branchiomotor neuron def: "Cranial motor neuron which innervates muscles derived from the branchial (pharyngeal) arches." [ZFIN:CVS] subset: human_subset subset: mouse_subset synonym: "branchi motor neuron" EXACT [] synonym: "special visceral motor neuron" EXACT [] xref: PMID:14699587 xref: ZFA:0005731 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0015000 ! cranial motor neuron intersection_of: CL:0015000 ! cranial motor neuron intersection_of: RO:0002130 UBERON:0004164 ! has synaptic terminal in branchiomeric muscle relationship: RO:0002130 UBERON:0004164 ! has synaptic terminal in branchiomeric muscle [Term] id: CL:0005024 name: somatomotor neuron def: "A motor neuron that innervates a skeletal muscle. These motor neurons are all excitatory and cholinergic." [ZFIN:CVS] subset: human_subset subset: mouse_subset synonym: "somatic motor neuron" EXACT [] xref: ZFA:0005733 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000100 ! motor neuron is_a: CL:0000108 ! cholinergic neuron intersection_of: CL:0000100 ! motor neuron intersection_of: RO:0002120 CL:0008002 ! synapsed to skeletal muscle fiber relationship: RO:0002120 CL:0008002 ! synapsed to skeletal muscle fiber [Term] id: CL:0005025 name: visceromotor neuron def: "A motor neuron that synapses to parasympathetic neurons that innervate tear glands, sweat glands, and the smooth muscles and glands of the pulmonary, cardiovascular, and gastrointestinal systems." [ZFIN:CVS] comment: Note that these neurons do not synapse directly onto muscles subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "general visceral motor neuron" EXACT [] xref: ZFA:0005732 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: BFO:0000002 is_a: CL:0000100 ! motor neuron relationship: RO:0002120 CL:0011102 ! synapsed to parasympathetic neuron property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0005025" xsd:string {name="visceromotor neuron on CELLxGENE CellGuide"} property_value: terms:description "Visceromotor neurons, also known as autonomic motor neurons, are an integral component of the body's autonomic nervous system, which controls and regulates internal body processes such as digestion, circulation, and respiration, autonomously from conscious control. These neurons regulate the motor functions of internal organs and glands, and serve as the effector neurons of the autonomic nervous system, conveying the signals from the central nervous system to execute actions.Visceromotor neurons are predominantly subdivided into two main functionally distinct categories: sympathetic and parasympathetic neurons.\nSympathetic visceromotor neurons tend to stimulate action, conserving energy for times of impending threat or when increased alertness is required. These neurons often act to increase heart rate, expand air passages allowing for greater oxygen flow to the muscles and brain, slow digestion, and produce a surge of glucose (sugar) in the bloodstream to cater to the energy demands during periods of heightened activity or stress.\nParasympathetic visceromotor neurons typically take effect during periods of calm, and are responsible for what's often termed as \"rest and digest\" activities. They govern a variety of activities collectively aimed at restoring and conserving bodily energy. Parasympathetic visceromotor neurons act to conserve energy by slowing the heart rate, increasing intestinal and gland activity, and relaxing sphincter muscles in the gastrointestinal tract. The complementary functions of these two types of visceromotor neurons enable the body to maintain an overall balance, or homeostasis, responding appropriately under different conditions and demands. Without the dynamic and essential functioning of visceromotor neurons, the body would lose its capability to autonomously regulate essential processes, thereby exposing it to potentially harmful internal conditions.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1016/0165-1838(81)90068-0", xref="DOI:10.1177/0148607108321705", xref="DOI:10.3389/fncel.2014.00293", xref="DOI:10.3389/fphys.2021.700129", xref="https://www.ncbi.nlm.nih.gov/books/NBK554616/"} [Term] id: CL:0005026 name: hepatoblast def: "Multi fate stem cell that gives rise to both hepatocytes and cholangiocytes as descendants. The term often refers to fetal precursors of hepatocytes (differently from 'hepatic stem cell', usually applied to the self-renewing pool of hepatocyte precursors in the adult liver). Hepatoblasts may also be endogenous, as some stem cells found in the liver come from the bone marrow via blood circulation." [GOC:CVS, https://orcid.org/0000-0003-1940-6740, PMID:18356246, PMID:20483998, PMID:26798363] subset: cellxgene_subset subset: human_subset subset: mouse_subset is_a: CL:0000048 ! multi fate stem cell property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0005026" xsd:string {name="hepatoblast on CELLxGENE CellGuide"} property_value: seeAlso "https://github.com/obophenotype/cell-ontology/issues/800" xsd:string property_value: terms:description "Hepatoblasts are immature precursor cells that predominate during the early stages of liver development, specifically in the embryonic phase of life. They first arise from the endoderm, one of the three primary germ layers in the very early embryo, and then differentiate into two distinct mature liver cell types - the hepatocytes and cholangiocytes. \nDuring liver organogenesis hepatoblasts proliferate and migrate into the septum transversum to form the liver bud. Proliferation and differentiation of these cells are regulated by several soluble factors, such as hepatocyte growth factor, which is a mitogen of both hepatoblasts and mature hepatocytes. As they start to differentiate into hepatocytes and cholangiocytes, the cells begin to express hepatic markers like albumin and alpha-fetoprotein. \nAlthough hepatoblasts are specified embryonic liver cells that are bipotential for hepatocytes and cholangiocytes, a subset of liver cells (called oval cells) has been identified in adults that express stem cell markers, such as CD133 and cKIT, and has been suggested to have the same potential as hepatoblasts to differentiate into hepatocytes and cholangiocytes.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1016/j.stem.2014.04.010", xref="DOI:10.1093/jb/mvr001", xref="DOI:10.1242/dev.031369", xref="DOI:10.1242/dev.114215", xref="DOI:10.5966/sctm.2015-0051"} [Term] id: CL:0007000 name: preameloblast def: "Skeletogenic cell that has the potential to develop into an ameloblast. Located in the inner enamel epithelium, these cells elongate, their nuclei shift distally (away from the dental papilla), and their cytoplasm becomes filled with organelles needed for synthesis and secretion of enamel proteins." [GO_REF:0000034, PMCID:PMC2737325] comment: unsure of neural crest contribution. In VSAO we have develops_from CL:0000008 subset: human_subset subset: mouse_subset is_a: CL:0011026 ! progenitor cell relationship: BFO:0000050 UBERON:0005176 ! part of tooth enamel organ relationship: RO:0002202 CL:0002077 ! develops from ecto-epithelial cell relationship: RO:0002220 UBERON:0001763 ! adjacent to odontogenic papilla property_value: terms:contributor https://orcid.org/0000-0001-9114-8737 creation_date: 2012-06-15T01:27:01Z [Term] id: CL:0007001 name: skeletogenic cell def: "Cell that has the potential to form a skeletal cell type (e.g. cells in periosteum, cells in marrow) and produce extracellular matrix (often mineralized) and skeletal tissue (often mineralized)." [GO_REF:0000034] comment: Needs logical definition. Should be capable_of skeletal system morphogenesis? or skeletal tissue development? needs to be added to GO. NOTES:a cell type of the early embryo (see also: mesenchymal cells) that will give rise to mineralized connective tissue. Scleroblasts can differentiate into osteoblasts (bone-forming cells), chondroblasts (cartilage-forming cells), odontoblasts (dentin-forming cells), ameloblasts (enamel-forming cells). The mesenchymal cells developing into osteoblasts and chondroblasts are derived from the mesoderm. Those developing into odontoblasts are neural crest cells. Those developing into ameloblasts are derived from the ectoderm. (http://www.copewithcytokines.de/cope.cgi?key=scleroblasts) subset: human_subset subset: mouse_subset synonym: "scleroblast" EXACT [GO_REF:0000034] is_a: CL:0000000 ! cell property_value: skos:prefLabel "skeletogenic cell" xsd:string property_value: terms:contributor https://orcid.org/0000-0001-9114-8737 creation_date: 2012-06-15T02:51:27Z [Term] id: CL:0007002 name: precementoblast def: "Skeletogenic cell that has the potential to develop into a cementoblast." [GO_REF:0000034] subset: human_subset subset: mouse_subset is_a: CL:0011026 ! progenitor cell relationship: BFO:0000050 UBERON:0005176 ! part of tooth enamel organ property_value: terms:contributor https://orcid.org/0000-0001-9114-8737 creation_date: 2012-06-15T04:37:13Z [Term] id: CL:0007003 name: preodontoblast def: "Skeletogenic cell that has the potential to form an odontoblast, deposits predentine, and arises from a cranial neural crest cell." [GO_REF:0000034] subset: human_subset subset: mouse_subset is_a: CL:0011026 ! progenitor cell relationship: BFO:0000050 UBERON:0005176 ! part of tooth enamel organ relationship: RO:0002202 CL:0000008 ! develops from migratory cranial neural crest cell property_value: terms:contributor https://orcid.org/0000-0001-9114-8737 creation_date: 2012-06-15T05:15:11Z [Term] id: CL:0007004 name: premigratory neural crest cell def: "Cell that is part of the neural crest region of the neuroepithelium, prior to migration. Note that not all premigratory neural crest cells may become migratory neural crest cells." [UBERONREF:0000002] subset: cellxgene_subset subset: human_subset subset: mouse_subset xref: ZFA:0007084 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: BFO:0000002 is_a: CL:0011012 ! neural crest cell relationship: BFO:0000050 UBERON:0002342 ! part of neural crest relationship: RO:0002202 CL:0000133 ! develops from neurectodermal cell property_value: skos:prefLabel "premigratory neural crest cell" xsd:string property_value: terms:contributor https://orcid.org/0000-0001-9114-8737 creation_date: 2012-06-27T08:27:35Z [Term] id: CL:0007005 name: notochordal cell def: "Cell that is part of the notochord." [GO_REF:0000034] comment: NOTE: TO DO, notochord development still needs work. subset: cellxgene_subset subset: human_subset subset: mouse_subset is_a: BFO:0000002 is_a: CL:0000255 ! eukaryotic cell relationship: BFO:0000050 UBERON:0002328 ! part of notochord relationship: RO:0002202 CL:0007006 ! develops from chordamesodermal cell property_value: terms:contributor https://orcid.org/0000-0001-9114-8737 creation_date: 2012-06-27T08:47:31Z [Term] id: CL:0007006 name: chordamesodermal cell def: "Mesodermal cell that is axially located and gives rise to the cells of the notochord." [GO_REF:0000034] subset: human_subset subset: mouse_subset synonym: "axial mesodermal cell" EXACT [] is_a: CL:0000222 ! mesodermal cell relationship: BFO:0000050 UBERON:0004880 ! part of chordamesoderm property_value: terms:contributor https://orcid.org/0000-0001-9114-8737 creation_date: 2012-06-27T08:52:41Z [Term] id: CL:0007007 name: notochordal sheath cell def: "Notochordal cell that is part of the outer epithelium of the notochord and surrounds the vacuolated notochord cells." [CL:MAH] subset: human_subset subset: mouse_subset xref: ZFA:0005744 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0007005 ! notochordal cell property_value: terms:contributor https://orcid.org/0000-0001-9114-8737 creation_date: 2012-06-27T09:26:37Z [Term] id: CL:0007008 name: notochordal vacuole cell def: "Notochordal cell that is inner portion of the notochord and becomes vacuolated as development proceeds." [CL:MAH] subset: human_subset subset: mouse_subset synonym: "chordablast" EXACT [GO_REF:0000034] synonym: "chordoblast" EXACT [PMID:14574572] is_a: CL:0007005 ! notochordal cell property_value: terms:contributor https://orcid.org/0000-0001-9114-8737 creation_date: 2012-06-27T09:29:30Z [Term] id: CL:0007009 name: prechondroblast def: "Skeletogenic cell that has the potential to develop into a chondroblast; and arises from neural crest, meseosdermal and notochordal and connective tissue cells." [GO_REF:0000034] subset: human_subset subset: mouse_subset is_a: CL:0011026 ! progenitor cell property_value: skos:prefLabel "prechondroblast" xsd:string property_value: terms:contributor https://orcid.org/0000-0001-9114-8737 creation_date: 2012-06-27T10:44:01Z [Term] id: CL:0007010 name: preosteoblast def: "Skeletogenic cell that has the potential to transform into an osteoblast, and develops from neural crest or mesodermal cells." [GO_REF:0000034] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "osteoprogenitor cell" EXACT [] is_a: CL:0001035 ! bone cell is_a: CL:0002320 ! connective tissue cell is_a: CL:0011026 ! progenitor cell relationship: BFO:0000050 UBERON:0008883 ! part of osteoid relationship: RO:0002202 CL:0000222 ! develops from mesodermal cell relationship: RO:0002202 CL:0000333 ! develops from migratory neural crest cell property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0007010" xsd:string {name="preosteoblast on CELLxGENE CellGuide"} property_value: terms:contributor https://orcid.org/0000-0001-9114-8737 property_value: terms:description "Preosteoblast is a critical cell type involved in bone formation, crucial in a process known as ossification or osteogenesis. They are derived from mesenchymal stem cells and are an intermediate stage marking the transition from an osteoprogenitor cell to a fully differentiated osteoblast. The presence of preosteoblasts signifies the site of new bone deposition, highlighting their crucial role in skeletal development and in response to bone injury repairs.\nThe primary function of preosteoblasts is to differentiate into osteoblasts, which are responsible for secreting osteoid (the unmineralized portion of bone matrix) and regulating the process of bone mineralization. Preosteoblasts are regulated by various growth factors and hormones, including bone morphogenic proteins (BMPs), fibroblast growth factors (FGFs), parathyroid hormone (PTH) and Vitamin D.\nHowever, the function of preosteoblasts is not limited to bone formation alone. In addition to osteogenesis, preosteoblasts significantly contribute to the maintenance of bone homeostasis through regulating the activity of osteoclasts - the cells responsible for bone resorption. This regulation is mediated through RANK/RANKL/OPG pathway signaling. Osteoprotegerin (OPG) released from the preosteoblasts acts as a decoy receptor for RANKL impairing osteoclast formation, hence preventing excessive bone resorption. This regulatory role indicates the dual functionality of preosteoblasts, which are indispensable for both the formation of new bone and the maintenance of existing bone tissue.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1038/srep32884", xref="DOI:10.1096/fba.2020-00058", xref="DOI:10.1210/endo.141.9.7634", xref="DOI:10.12659/MSMBR.901142"} creation_date: 2012-06-27T10:57:21Z [Term] id: CL:0007011 name: enteric neuron def: "Neuron that is part of the enteric nervous system." [CL:MAH] subset: cellxgene_subset subset: human_subset subset: mouse_subset xref: ZFA:0005775 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000029 ! neural crest derived neuron is_a: CL:0000107 ! autonomic neuron intersection_of: CL:0000540 ! neuron intersection_of: RO:0002100 UBERON:0002005 ! has soma location enteric nervous system relationship: BFO:0000050 UBERON:0002005 ! part of enteric nervous system relationship: RO:0002100 UBERON:0002005 ! has soma location enteric nervous system relationship: RO:0002202 CL:0002607 ! develops from migratory enteric neural crest cell property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0007011" xsd:string {name="enteric neuron on CELLxGENE CellGuide"} property_value: terms:contributor https://orcid.org/0000-0001-9114-8737 property_value: terms:description "Enteric neurons, also known as the neurons of the enteric nervous system (ENS), form a vast and complex network within the walls of the gastrointestinal tract. These unique cells constitute the principal component of the ENS, which is often referred to as the \"second brain\" or the gut's brain, due to its autonomy from the central nervous system (CNS). While the ENS does communicate with the CNS, it can function independently, thereby playing an essential role in maintaining the body's homeostasis.\nEnteric neurons are incredibly diverse in function and morphology. Integral to essential processes like peristalsis, secretion, and blood flow regulation, these neurons are further classified into different types based on their roles. The organization of the ENS is characterized by two main ganglionated layers: the inner submucosal (Meissner's) plexus, involved primarily in regulating gastrointestinal blood flow and epithelial cell function, and the outer myenteric (Auerbach's) plexus, which predominantly manages gut motility.\nEnteric neurons play a significant role in sensing and responding to changes within the gut environment. First, they detect physical and chemical changes, for instance, the arrival of food, and respond accordingly by adjusting gut motility and secretions. Second, they communicate information about the state of the gut to the CNS; however, much of the routine detailed management of the digestive system is carried out within the ENS itself. In addition, they also interact with the gut's large microbial population and the immune system, playing a pivotal role in health and disease. Dysfunctions or alterations in the enteric neurons may contribute to various gastrointestinal disorders, such as functional dyspepsia or irritable bowel syndrome, and neurodegenerative diseases such as Parkinson's.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1016/j.immuni.2017.05.011", xref="DOI:10.1038/nrgastro.2012.32", xref="DOI:10.1038/nrgastro.2016.107", xref="DOI:10.1038/s41575-020-0271-2", xref="https://www.ncbi.nlm.nih.gov/books/NBK551559/"} creation_date: 2012-06-28T08:20:31Z [Term] id: CL:0007012 name: non-terminally differentiated odontoblast def: "Odontoblast that non-terminally differentiated, located in the odontogenic papilla and dentine tissue, and transforms from a odontoblast cell." [GO_REF:0000034, PSPUB:0000170] subset: human_subset subset: mouse_subset is_a: CL:0000060 ! odontoblast is_a: CL:0011026 ! progenitor cell [Term] id: CL:0007013 name: terminally differentiated odontoblast def: "Odontoblast that is terminally differentiated and derived from an odontogenic papilla and associated with dentine." [GO_REF:0000034] subset: human_subset subset: mouse_subset is_a: CL:0000060 ! odontoblast [Term] id: CL:0007014 name: obsolete cell line cell def: "OBSOLETE: A cultured cell that has been passaged at least one time in culture." [ReO:mhb] comment: Obsoleted in July 2013 and replaced by the CLO 'cell line cell' class, as a result of CLO-OBI-CL alignment efforts.\n\nCovers cells actively being cultured or stored in a quiescent state for future use. synonym: "passaged cultured cell" EXACT [] property_value: terms:contributor https://orcid.org/0000-0001-9114-8737 is_obsolete: true replaced_by: CLO:0000001 creation_date: 2012-11-28T11:54:59Z [Term] id: CL:0007015 name: obsolete mortal cell line cell def: "OBSOLETE: A cell line cell that is expected to be capable of replicating a limited number of times in culture before undergoing senescence. Mortal cell line cells cannot be propagated indefinitely (as immortal cell line cells can)." [ReO:mhb] comment: Obsoleted in July 2013 and replaced by the CLO 'mortal cell line cell' class, as a result of CLO-OBI-CL alignment efforts.\n\nCovers cells actively being cultured or stored in a quiescent state for future use. synonym: "finite cell line cell" EXACT [] synonym: "primary cell line cell" RELATED [] property_value: terms:contributor https://orcid.org/0000-0001-9114-8737 is_obsolete: true replaced_by: CLO:0000018 creation_date: 2012-11-28T11:56:20Z [Term] id: CL:0007016 name: adaxial cell def: "Muscle precursor cell that is adjacent to the notochord and part of the presomitic mesoderm." [PMID:8951054] comment: In teleosts, adaxial cells give rise to slow muscle myoblasts. subset: human_subset subset: mouse_subset xref: ZFA:0000003 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000680 ! muscle precursor cell relationship: BFO:0000050 UBERON:0003059 ! part of presomitic mesoderm property_value: terms:contributor https://orcid.org/0000-0001-9114-8737 creation_date: 2012-12-30T12:43:15Z [Term] id: CL:0007017 name: Stiftchenzellen def: "An epidermal cell with apical microvilli or a single apical projection have synaptic associations with nerve fibres in the epidermis." [PMID:1087183] comment: Taxon specificity not yet fully known, but are known in anuran larvae but not in adults. subset: human_subset subset: mouse_subset is_a: CL:0000206 ! chemoreceptor cell relationship: BFO:0000050 UBERON:0001003 ! part of skin epidermis relationship: BFO:0000051 GO:0005902 ! has part microvillus property_value: terms:contributor https://orcid.org/0000-0001-9114-8737 [Term] id: CL:0007018 name: epidermal ciliary cell def: "Ciliated cell of the embryonic epidermis and functions in embryonic movements." [PMCID:PMC3046089] comment: Taxon specificity not clear -present in embryonic anurans. subset: human_subset subset: mouse_subset is_a: CL:0000064 ! ciliated cell is_a: CL:0002321 ! embryonic cell (metazoa) relationship: BFO:0000050 UBERON:0001003 ! part of skin epidermis property_value: terms:contributor https://orcid.org/0000-0001-9114-8737 [Term] id: CL:0007019 name: epidermal mucus secreting cell comment: taxon specificity not clear. Appears in early larval stages of anurans and persists after metamorphosis. subset: human_subset subset: mouse_subset is_a: CL:0000319 ! mucus secreting cell property_value: terms:contributor https://orcid.org/0000-0001-9114-8737 [Term] id: CL:0007020 name: bottle cell def: "Characteristic early embryonic cell with a bottle or flask shape that is first to migrate inwards at the blastopore during gastrulation in amphibians." [PMID:3197630] subset: human_subset subset: mouse_subset is_a: CL:0000007 ! early embryonic cell (metazoa) property_value: terms:contributor https://orcid.org/0000-0001-9114-8737 [Term] id: CL:0007021 name: alarm substance cell def: "Secretory cell that produces a chemical mixture that triggers antipredator behavior. The substance is released only upon disruption of the epidermis. [Behavior of teleost fishes, second edition, edited by Pitcher, 1992]" [ISBN-10:0412429403] subset: human_subset subset: mouse_subset synonym: "alarm substance secreting cell" EXACT [] synonym: "club cell" RELATED [https://github.com/obophenotype/cell-ontology/issues/583, ISBN-10:0412429403] synonym: "club cell (zebrafish)" EXACT [https://github.com/obophenotype/cell-ontology/issues/583] is_a: CL:0000151 ! secretory cell is_a: CL:0000255 ! eukaryotic cell relationship: BFO:0000050 UBERON:0001003 ! part of skin epidermis property_value: terms:contributor https://orcid.org/0000-0001-9114-8737 [Term] id: CL:0007022 name: micropylar cell def: "A specialized pore forming cell of the follicle, located adjacent to the animal pole of the oocyte. The micropylar cell makes the single micropyle (pore) through the chorion through which the sperm fertilizes the egg." [PMID:18582455, ZFA:0005239] subset: human_subset subset: mouse_subset synonym: "plug cell" EXACT [] xref: ZFA:0005239 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0002174 ! follicular cell of ovary property_value: terms:contributor https://orcid.org/0000-0001-9114-8737 [Term] id: CL:0007023 name: flask cell def: "Epidermal cell rich in mitochondria. In amphibians, appears during metamorphosis." [DOI:10.1007/BF00717048] subset: human_subset subset: mouse_subset is_a: CL:0000255 ! eukaryotic cell relationship: BFO:0000050 UBERON:0001003 ! part of skin epidermis property_value: terms:contributor https://orcid.org/0000-0001-9114-8737 [Term] id: CL:0008000 name: non-striated muscle cell def: "Any muscle cell in which the fibers are not organised into sarcomeres." [GOC:DOS] subset: human_subset subset: mouse_subset is_a: CL:0000187 ! muscle cell property_value: skos:prefLabel "non-striated muscle cell" xsd:string [Term] id: CL:0008001 name: hematopoietic precursor cell def: "Any hematopoietic cell that is a precursor of some other hematopoietic cell type." [GOC:dos] subset: cellxgene_subset subset: human_subset subset: mouse_subset is_a: CL:0000988 ! hematopoietic cell property_value: skos:prefLabel "hematopoietic precursor cell" xsd:string [Term] id: CL:0008002 name: skeletal muscle fiber def: "A transversely striated, synctial cell of skeletal muscle. It is formed when proliferating myoblasts exit the cell cycle, differentiate and fuse." [GOC:tfm, ISBN:0323052908] subset: cellxgene_subset subset: human_subset subset: mouse_subset xref: MESH:D018485 is_a: CL:0000188 ! cell of skeletal muscle is_a: CL:0002372 ! myotube intersection_of: CL:0000187 ! muscle cell intersection_of: BFO:0000050 UBERON:0001134 ! part of skeletal muscle tissue intersection_of: BFO:0000051 GO:0030017 ! has part sarcomere intersection_of: RO:0000053 PATO:0001908 ! has characteristic multinucleate intersection_of: RO:0000053 PATO:0002478 ! has characteristic transversely striated relationship: RO:0002202 CL:0000515 ! develops from skeletal muscle myoblast property_value: skos:prefLabel "skeletal muscle fiber" xsd:string [Term] id: CL:0008003 name: somatic muscle myotube def: "A myotube that is part of some somatic muscle. Examples include arthropod somatic muscle cells." [PMID:22274696, PMID:8720463] subset: human_subset subset: mouse_subset is_a: CL:0002372 ! myotube is_a: CL:0008004 ! somatic muscle cell intersection_of: CL:0008004 ! somatic muscle cell intersection_of: BFO:0000051 GO:0030017 ! has part sarcomere intersection_of: RO:0000053 PATO:0001908 ! has characteristic multinucleate intersection_of: RO:0000053 PATO:0002478 ! has characteristic transversely striated [Term] id: CL:0008004 name: somatic muscle cell def: "A muscle cell that is part of some somatic muscle." [GOC:dos] subset: human_subset subset: mouse_subset xref: FBbt:00005073 {sssom:mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"} is_a: CL:0000187 ! muscle cell [Term] id: CL:0008005 name: obliquely striated somatic muscle cell def: "A somatic muscle cell that is obliquely striated and mononucleated. Examples include the somatic muscles of nematodes." [doi:10.3908/wormatlas.1.7, PMID:8720463] subset: human_subset subset: mouse_subset is_a: CL:0000226 ! single nucleate cell is_a: CL:0000444 ! obliquely striated muscle cell is_a: CL:0008004 ! somatic muscle cell intersection_of: CL:0008004 ! somatic muscle cell intersection_of: BFO:0000051 GO:0030017 ! has part sarcomere intersection_of: RO:0000053 PATO:0001407 ! has characteristic mononucleate intersection_of: RO:0000053 PATO:0002479 ! has characteristic obliquely striated [Term] id: CL:0008006 name: muscle founder cell def: "A myoblast that detemines the properties (size, shape and attachment to the epidermis) of a `somatic muscle myotube` (CL:0008003) . It develops into a somatic muscle myotube via fusion with `fusion component myoblasts` (CL:0000621)." [PMID:22274696] subset: human_subset subset: mouse_subset is_a: CL:0008018 ! somatic muscle myoblast [Term] id: CL:0008007 name: visceral muscle cell def: "A muscle cell that is part of some visceral muscle." [GOC:dos] subset: human_subset subset: mouse_subset xref: FBbt:00005070 {sssom:mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"} is_a: CL:0000187 ! muscle cell intersection_of: CL:0000187 ! muscle cell intersection_of: BFO:0000050 UBERON:8600004 ! part of visceral muscle tissue relationship: BFO:0000050 UBERON:8600004 ! part of visceral muscle tissue property_value: skos:prefLabel "visceral muscle cell" xsd:string [Term] id: CL:0008008 name: striated visceral muscle cell def: "A visceral muscle cell that is striated. Examples include the visceral muscle cells of arhtropods." [GOC:dos] subset: human_subset subset: mouse_subset is_a: CL:0000737 ! striated muscle cell is_a: CL:0008007 ! visceral muscle cell intersection_of: CL:0008007 ! visceral muscle cell intersection_of: RO:0000053 PATO:0001410 {all_some="true"} ! has characteristic striated [Term] id: CL:0008009 name: transversely striated visceral muscle cell def: "A visceral muscle that is transversely striated. Examples include the visceral muscle cells of arthropods." [GOC:dos] subset: human_subset subset: mouse_subset is_a: CL:0008008 ! striated visceral muscle cell intersection_of: CL:0008007 ! visceral muscle cell intersection_of: RO:0000053 PATO:0002478 {all_some="true"} ! has characteristic transversely striated relationship: RO:0000053 PATO:0002478 ! has characteristic transversely striated [Term] id: CL:0008010 name: cranial somatomotor neuron def: "A cranial motor neuron whose soma is located in the midbrain andor hindbrain and which innervates the skeletal muscles of the eye or tongue." [PMID:14699587] subset: human_subset subset: mouse_subset is_a: CL:0005024 ! somatomotor neuron is_a: CL:0015000 ! cranial motor neuron intersection_of: CL:0015000 ! cranial motor neuron intersection_of: RO:0002120 CL:0008002 ! synapsed to skeletal muscle fiber [Term] id: CL:0008011 name: skeletal muscle satellite stem cell def: "A skeletal muscle satellite cell that divides by stem cell division. A proportion of this population undergoes symmetric stem cell division, producing two skeletal muscle satellite stem cells. The rest undergo asymmetric stem cell division - retaining their identity while budding off a daughter cell that differentiates into an adult skeletal muscle myoblast." [PMID:23303905] subset: cellxgene_subset subset: human_subset subset: mouse_subset is_a: CL:0000035 ! single fate stem cell is_a: CL:0000594 ! skeletal muscle satellite cell intersection_of: CL:0000594 ! skeletal muscle satellite cell intersection_of: RO:0000053 PATO:0001400 ! has characteristic unipotent intersection_of: RO:0002215 GO:0017145 ! capable of stem cell division disjoint_from: CL:0008020 ! skeletal muscle satellite myogenic cell [Term] id: CL:0008012 name: quiescent skeletal muscle satellite cell def: "A skeletal muscle satellite cell that is mitotically quiescent. These cells are wedge shaped and have a large nuclear to cytoplasmic ratio with few organelles, a small nucleus and condensed interphase chromatin. Satellite cells typically remain in this state until activated following muscle damage." [PMID:21849021, PMID:23303905] subset: human_subset subset: mouse_subset is_a: CL:0000594 ! skeletal muscle satellite cell [Term] id: CL:0008013 name: cranial visceromotor neuron def: "A visceromotor motor neuron whose soma is located in the hindbrain, and which synapses to parasympathetic neurons that innervate tear glands, sweat glands, and the smooth muscles of the head." [PMID:14699587] subset: human_subset subset: mouse_subset is_a: CL:0005025 ! visceromotor neuron is_a: CL:0015000 ! cranial motor neuron is_a: CL:2000029 ! central nervous system neuron intersection_of: CL:0005025 ! visceromotor neuron intersection_of: RO:0002100 UBERON:0002028 ! has soma location hindbrain relationship: RO:0002100 UBERON:0002028 ! has soma location hindbrain [Term] id: CL:0008014 name: obsolete excitatory motor neuron def: "A motor neuron that is capable of directly inducing muscle contraction." [] comment: In vertebrates, all motor neurons are excitatory, but various types of inhibitory motor neurons exist in invertebrates. is_obsolete: true [Term] id: CL:0008015 name: inhibitory motor neuron def: "A motor neuron that is capable of directly inhibiting muscle contraction." [] comment: In vertebrates, all motor neurons are excitatory, but various types of inhibitory motor neurons exist in invertebrates. subset: cellxgene_subset is_a: CL:0000100 ! motor neuron property_value: RO:0002161 NCBITaxon:7742 [Term] id: CL:0008016 name: activated skeletal muscle satellite cell def: "A skeletal muscle satellite cell that has become mitotically active - typically following muscle damage." [PMID:21849021, PMID:23303905] subset: human_subset subset: mouse_subset is_a: CL:0000594 ! skeletal muscle satellite cell relationship: RO:0002202 CL:0008012 {comment="More accurately - transformation_of ?"} ! develops from quiescent skeletal muscle satellite cell [Term] id: CL:0008017 name: adult skeletal muscle myoblast def: "A skeletal muscle myoblast that is part of a skeletal mucle. These cells are formed following acivation and division of skeletal muscle satellite cells. They form a transient population that is lost when they fuse to form skeletal muscle fibers." [PMID:23303905] comment: The vast majority of these cells develop from skeletal muscle satellite cells, although there are some reports of other origins. subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "myogenic precursor cell" BROAD [PMID:23303905] is_a: CL:0000188 ! cell of skeletal muscle is_a: CL:0000515 ! skeletal muscle myoblast intersection_of: CL:0000056 ! myoblast intersection_of: BFO:0000050 UBERON:0001134 ! part of skeletal muscle tissue intersection_of: RO:0002203 CL:0008002 ! develops into skeletal muscle fiber [Term] id: CL:0008018 name: somatic muscle myoblast def: "A myoblast that is commited to developing into a somatic muscle." [] subset: human_subset subset: mouse_subset is_a: CL:0000056 ! myoblast intersection_of: CL:0000056 ! myoblast intersection_of: RO:0002203 CL:0008003 ! develops into somatic muscle myotube relationship: RO:0002203 CL:0008003 ! develops into somatic muscle myotube [Term] id: CL:0008019 name: mesenchymal cell def: "A non-polarised cell precursor cell that is part of some mesenchyme, is associated with the cell matrix but is not connected to other cells and is capable of migration." [] subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "mesenchyme cell" EXACT [] is_a: CL:0000219 ! motile cell relationship: BFO:0000050 UBERON:0003104 ! part of mesenchyme relationship: RO:0002215 GO:0016477 ! capable of cell migration property_value: RO:0002175 NCBITaxon:9606 property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0008019" xsd:string {name="mesenchymal cell on CELLxGENE CellGuide"} property_value: skos:prefLabel "mesenchymal cell" xsd:string property_value: terms:description "Mesenchymal cells are a type of undifferentiated cell that possess the ability to develop into a wide variety of other cells. These cells originate from the mesoderm during embryonic development, which gives rise to tissues such as muscles, the skeletal system, and connective and vascular structures. Mesenchymal cells primarily function as progenitor cells with exceptional renewal capabilities and are characterized by their ability to migrate, aiding in tissue repair and regeneration.\nMesenchymal cells play a critical role in the development and maintenance of various biological systems throughout the body due to their versatility and adaptability. They can differentiate into more specialized cells, including osteoblasts, adipocytes, and chondrocytes, which are essential for bone, fat, and cartilage tissues, respectively. Furthermore, they contribute to the vascular and lymphatic systems through the formation of pericytes and lymphatic endothelial cells, securing the integrity of the circulatory system.\nIn the field of regenerative medicine, mesenchymal cells, particularly mesenchymal stem cells (MSCs), are of great interest due to their unique therapeutic potential. MSCs, for instance, have been implicated in wound healing and tissue repair because of their capacity to modulate the immune response. They can secrete a range of proteins and growth factors that aid in angiogenesis, the formation of new blood vessels, and the stimulation of resident progenitor cells to aid in tissue restoration.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1016/S0076-6879(06)20016-8", xref="DOI:10.1038/s41536-019-0083-6", xref="DOI:10.1089/scd.2016.0109", xref="DOI:10.1155/2016/1314709", xref="DOI:10.21037/sci.2019.08.11"} [Term] id: CL:0008020 name: skeletal muscle satellite myogenic cell def: "A skeletal muscle satellite cell that undergoes symmetric division to produce two adult skeleltal muscle myoblasts." [GOC:dos, PMID:23303905] subset: human_subset subset: mouse_subset is_a: CL:0000594 ! skeletal muscle satellite cell relationship: RO:0002203 CL:0008017 ! develops into adult skeletal muscle myoblast [Term] id: CL:0008021 name: anterior lateral line ganglion neuron def: "Any peripheral nervous system neuron that has its soma located in some anterior lateral line ganglion." [FBC:Autogenerated] is_a: CL:2000031 ! lateral line ganglion neuron intersection_of: CL:2000032 ! peripheral nervous system neuron intersection_of: RO:0002100 UBERON:2001391 ! has soma location anterior lateral line ganglion relationship: RO:0002100 UBERON:2001391 ! has soma location anterior lateral line ganglion [Term] id: CL:0008022 name: endocardial cushion cell def: "A mesenchymal cell of the endocardial cushion. These cells develop via an epithelial to mesenchymal transition when endocardial cells break cell-to-cell contacts and migrate into the cardiac jelly. Cells from this population form the heart septa and valves." [PMID:18816864] subset: human_subset subset: mouse_subset is_a: CL:0000569 ! cardiac mesenchymal cell is_a: CL:0002494 ! cardiocyte intersection_of: CL:0000569 ! cardiac mesenchymal cell intersection_of: BFO:0000050 UBERON:0002062 ! part of endocardial cushion relationship: BFO:0000050 UBERON:0002062 ! part of endocardial cushion [Term] id: CL:0008023 name: obsolete cardiac fibroblast comment: Duplicate term. is_obsolete: true replaced_by: CL:0002548 [Term] id: CL:0008024 name: pancreatic endocrine cell def: "An endocrine cell that is part of the pancreas." [GOC:dos] subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset is_a: CL:0000083 ! epithelial cell of pancreas is_a: CL:0000164 ! enteroendocrine cell intersection_of: CL:0000163 ! endocrine cell intersection_of: BFO:0000050 UBERON:0001264 ! part of pancreas property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0008025 name: noradrenergic neuron def: "A neuron that release noradrenaline (noriphinephrine) as a neurotransmitter." [GOC:dos] subset: human_subset subset: mouse_subset xref: ZFA:0005873 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000459 ! noradrenergic cell is_a: CL:4033050 ! catecholaminergic neuron intersection_of: CL:0000540 ! neuron intersection_of: RO:0002215 GO:0061533 ! capable of norepinephrine secretion, neurotransmission relationship: RO:0002215 GO:0061533 ! capable of norepinephrine secretion, neurotransmission [Term] id: CL:0008026 name: open tracheal system tracheocyte def: "An epithelial cell that is part of the epithelium of a tracheal tube in an open tracheal system, such as that found in insects." [GOC:dos] xref: FBbt:00005038 {sssom:mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"} is_a: CL:0000066 ! epithelial cell intersection_of: CL:0000066 ! epithelial cell intersection_of: BFO:0000050 UBERON:0003127 ! part of open tracheal system trachea relationship: BFO:0000050 UBERON:0003127 ! part of open tracheal system trachea [Term] id: CL:0008027 name: rod bipolar cell (sensu Mus) def: "A bipolar neuron found in the retina that is synapsed by rod photoreceptor cells. These neurons have axons that arborize and synapse to targets in inner plexiform layers 4 and 5 and depolarize in response to light." [] subset: human_subset subset: mouse_subset is_a: CL:0000751 ! rod bipolar cell property_value: terms:contributor https://orcid.org/0000-0002-7073-9172 creation_date: 2017-06-29T11:05:22Z [Term] id: CL:0008028 name: visual system neuron def: "Any neuron that is capable of part of some visual perception." [FBC:Autogenerated] subset: human_subset subset: mouse_subset is_a: CL:0000540 ! neuron intersection_of: CL:0000540 ! neuron intersection_of: RO:0002216 GO:0007601 ! capable of part of visual perception relationship: RO:0002216 GO:0007601 ! capable of part of visual perception property_value: skos:prefLabel "visual system neuron" xsd:string property_value: terms:contributor https://orcid.org/0000-0002-7073-9172 creation_date: 2017-07-09T19:12:36Z [Term] id: CL:0008029 name: obsolete inhibitory neuron comment: Consider GABAergic neuron or inhibitory interneuron instead. Do note that not all GABAergic neurons are inhibitory (see PMID:12209121) and replacing inhibitory neuron with GABAergic neuron should be done with caution. property_value: IAO:0000233 https://github.com/obophenotype/cell-ontology/issues/1540 property_value: terms:contributor https://orcid.org/0000-0002-7073-9172 is_obsolete: true creation_date: 2017-07-12T11:10:52Z [Term] id: CL:0008030 name: obsolete excitatory neuron comment: Consider using glutamatergic neuron instead. Do note that not all glutamatergic neurons are excitatory and replacing excitatory neuron with glutamatergic neuron should be done with caution. property_value: IAO:0000233 https://github.com/obophenotype/cell-ontology/issues/1540 property_value: terms:contributor https://orcid.org/0000-0002-7073-9172 is_obsolete: true creation_date: 2017-07-12T11:11:06Z [Term] id: CL:0008031 name: cortical interneuron def: "An interneuron that has its soma located in the cerebral cortex." [] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "cerebral cortex interneuron" EXACT [] is_a: CL:0000099 ! interneuron is_a: CL:0010012 ! cerebral cortex neuron intersection_of: CL:0000099 ! interneuron intersection_of: RO:0002100 UBERON:0000956 ! has soma location cerebral cortex property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0008031" xsd:string {name="cortical interneuron on CELLxGENE CellGuide"} property_value: terms:description "Cortical interneurons are a specialized type of neuron predominantly found in the cerebral cortex, the brain's outer layer responsible for higher cognitive functions. They constitute approximately 20-30% of all cortical neurons and are characterized by their crucial role in inhibiting the activity of other neurons in the brain, adding a critical dimension of control to neural activity and information processing.\nThese cortical interneurons are significantly implicated in maintaining the balance of excitation and inhibition in the cerebral cortex, which is essential for normal brain function. This balance allows the brain to respond appropriately to stimuli, modifying behavior and facilitating motor, sensory, and cognitive processes. Furthermore, cortical interneurons are instrumental in the generation of brain oscillations, rhythmic patterns of neuronal activity believed to contribute to various aspects of cognitive processes, such as attention, memory, and consciousness.\nTheir unique function and morphology, along with the numerous subtypes distinguished by differences in physiological properties, molecular expression profiles, and connectivity patterns, highlight the complexity and diversity of cortical interneurons. Dysfunction or abnormal development of these cells has been linked to various neurological disorders, including epilepsy, schizophrenia, and autism.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1016/j.conb.2017.08.018", xref="DOI:10.1016/j.conb.2023.102703", xref="DOI:10.1038/ncomms6333", xref="DOI:10.1038/nrn3155", xref="DOI:10.1242/dev.132852"} [Term] id: CL:0008032 name: rosehip neuron def: "A GABAergic interneuron in human cortical layer 1 that has large rosehip-shaped axonal boutons and compact arborization." [doi:10.1038/s41593-018-0205-2] comment: A rosehip cell has been shown to have an immunohistochemical profile GAD1+CCK+, CNR1–SST–CALB2–PVALB– that matches a single transcriptomically defined cell type whose specific molecular marker signature is not seen in mouse cortex. {xref="doi:10.1038/s41593-018-0205-2"} subset: human_subset is_a: BFO:0000002 is_a: CL:0010011 ! cerebral cortex GABAergic interneuron relationship: RO:0002100 UBERON:0005390 ! has soma location cortical layer I relationship: RO:0002162 NCBITaxon:9606 ! in taxon Homo sapiens relationship: RO:0002292 PR:000005110 ! expresses cholecystokinin relationship: RO:0002292 PR:000007785 ! expresses glutamate decarboxylase 1 relationship: RO:0002292 PR:000011467 ! expresses netrin-G1 [Term] id: CL:0008033 name: decidual pericyte def: "A pericyte of the decidual vasculature." [PMID:30429548] subset: added_for_HCA subset: human_subset subset: mouse_subset synonym: "decidual perivascular cell" EXACT [] is_a: CL:0000349 ! extraembryonic cell is_a: CL:2000078 ! placental pericyte intersection_of: CL:0000669 ! pericyte intersection_of: BFO:0000050 UBERON:0002450 ! part of decidua relationship: BFO:0000050 UBERON:0002450 ! part of decidua property_value: terms:contributor https://orcid.org/0000-0002-7073-9172 creation_date: 2020-02-29T11:45:57Z [Term] id: CL:0008034 name: mural cell def: "Mural cells are pericytes and the vascular smooth muscle cells (vSMCs) of the microcirculation." [Wiki:Mural_cell&oldid=930603194] subset: added_for_HCA subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset xref: ZFA:0005944 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:4033054 ! perivascular cell property_value: RO:0002175 NCBITaxon:9606 property_value: terms:contributor https://orcid.org/0000-0002-7073-9172 creation_date: 2020-02-29T17:33:55Z [Term] id: CL:0008035 name: microcirculation associated smooth muscle cell def: "Any vascular associated smooth muscle cell that is part of some microcirculatory vessel." [FBC:Autogenerated] subset: cellxgene_subset subset: human_subset subset: mouse_subset is_a: CL:0000359 ! vascular associated smooth muscle cell is_a: CL:0008034 ! mural cell intersection_of: CL:0000359 ! vascular associated smooth muscle cell intersection_of: BFO:0000050 UBERON:0010523 ! part of microcirculatory vessel relationship: BFO:0000050 UBERON:0010523 ! part of microcirculatory vessel property_value: terms:contributor https://orcid.org/0000-0002-7073-9172 creation_date: 2020-02-29T17:37:00Z [Term] id: CL:0008036 name: extravillous trophoblast def: "A trophoblast cell that is not part of a placental villous." [PMID:31049600] subset: added_for_HCA subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "EVT" EXACT [PMID:31049600] synonym: "extravillous cytotrophloblast" EXACT [] is_a: CL:0000351 ! trophoblast cell property_value: RO:0002175 NCBITaxon:9606 property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0008036" xsd:string {name="extravillous trophoblast on CELLxGENE CellGuide"} property_value: terms:contributor https://orcid.org/0000-0002-7073-9172 property_value: terms:description "Extravillous trophoblasts (EVTs), a specialized subset of trophoblast cells, play crucial roles in establishing and sustaining pregnancy. \nFirstly, they anchor the fetus to the maternal tissue, providing structural stability. Secondly, they are instrumental in modifying the maternal spiral arteries to ensure an adequate supply of maternal blood to the placenta and the developing fetus. EVTs invade maternal decidua and myometrium and replace the endothelial lining of the spiral arteries, transforming these high-resistance, narrow vessels into low-resistance, wide vessels, favouring higher blood flow. Thirdly, these cells also play an immunological role, creating an environment conducive to the acceptance of the semi-allogeneic fetus, by expressing non-classical MHC molecules, thereby averting any potential maternal immune response towards fetal tissues.\nWhile EVTs are commonly associated with healthy pregnancies, abnormalities in their function or development have been connected to problematic pregnancies. Conditions like pre-eclampsia and fetal growth restriction (FGR) may arise if EVT cells do not effectively invade the maternal decidua or adequately remodel.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1007/s12522-011-0102-9", xref="DOI:10.1016/j.it.2017.01.009", xref="DOI:10.1016/j.preghy.2010.10.003", xref="DOI:10.1080/19336918.2015.1089376", xref="DOI:10.1080/19336918.2015.1120397"} creation_date: 2020-03-02T08:45:06Z [Term] id: CL:0008037 name: gamma motor neuron def: "A lower motor neuron that innervates only intrafusal muscle fibers. Unlike the alpha motor neurons, gamma motor neurons do not directly adjust the lengthening or shortening of muscles but function in adjusting the sensitivity of muscle spindles and in keeping muscle spindles taut, thereby allowing the continued firing of alpha neurons." [DOI:10.1093/acprof\:oso/9780195159561.001.1, WikipediaVersion:Gamma_motor_neuron&oldid=906640465] subset: human_subset subset: mouse_subset synonym: "fusimotor neuron" EXACT [WikipediaVersioned:Gamma_motor_neuron&oldid=1037462173] xref: FMA:83660 xref: MESH:D009047 xref: SAO:143800623 is_a: CL:0008039 ! lower motor neuron relationship: RO:0002120 CL:0008047 ! synapsed to intrafusal muscle fiber [Term] id: CL:0008038 name: alpha motor neuron def: "A large, multipolar lower motor neuron of the brainstem and spinal cord that innervates the extrafusal muscle fibers of skeletal muscle and are directly responsible for initiating their contraction. While their cell bodies are in the CNS (in the anterior gray horn of the spinal cord), they are part of the somatic nervous system - a branch of the PNS." [DOI:10.1016/B978-0-12-801238-3.05364-2, Wikipedia:Alpha_motor_neuron&oldid=957148643] subset: human_subset subset: mouse_subset synonym: "alpha motoneuron" EXACT [] is_a: CL:0008039 ! lower motor neuron relationship: RO:0002120 CL:0008046 ! synapsed to extrafusal muscle fiber property_value: terms:contributor https://orcid.org/0000-0002-7073-9172 creation_date: 2020-09-23T20:16:26Z [Term] id: CL:0008039 name: lower motor neuron def: "The motor neurons of vertebrates that directly innervate skeletal muscles. They receive input from upper motor neurons." [Wikipedia:Lower_motor_neuron&oldid=952547294] subset: human_subset subset: mouse_subset xref: FMA:84632 is_a: BFO:0000002 is_a: CL:0005024 ! somatomotor neuron relationship: RO:0002162 NCBITaxon:7742 ! in taxon Vertebrata property_value: terms:contributor https://orcid.org/0000-0002-7073-9172 creation_date: 2020-09-23T20:22:07Z [Term] id: CL:0008040 name: squamous endothelial cell of venule def: "An endothelial cell of the venule that is squamous shaped. This is in contrast to the cubodial shape of high endothelial venule cells." [GOC:tfm] subset: human_subset subset: mouse_subset is_a: CL:0002653 ! squamous endothelial cell is_a: CL:1000414 ! endothelial cell of venule property_value: terms:contributor https://orcid.org/0000-0002-7073-9172 property_value: terms:date "2024-07-03T19:52:47Z" xsd:dateTime [Term] id: CL:0008041 name: mesothelial cell of intestine def: "A mesothelial cell that is part of the intestinal serosa." [https://orcid.org/0000-0002-7073-9172] subset: human_subset subset: mouse_subset is_a: CL:0000077 ! mesothelial cell intersection_of: CL:0000077 ! mesothelial cell intersection_of: BFO:0000050 UBERON:0001243 ! part of serosa of intestine relationship: BFO:0000050 UBERON:0001243 ! part of serosa of intestine property_value: terms:contributor https://orcid.org/0000-0002-7073-9172 property_value: terms:date "2025-02-04T18:42:26Z" xsd:dateTime [Term] id: CL:0008042 name: tanycyte of subfornical organ def: "A tanycyte of the subfornical organ (SFO). These cells extend long and slender fibers extending from their cell bodies in the ependyma toward fenestrated capillaries associated with the SFO, where they form a dense network surrounding these capillaries." [PMID:23649873] subset: human_subset subset: mouse_subset synonym: "tanycyte-like cell of subfornical organ" EXACT [PMID:23649873] is_a: CL:0002085 ! tanycyte intersection_of: CL:0002085 ! tanycyte intersection_of: BFO:0000050 UBERON:0002219 ! part of subfornical organ relationship: BFO:0000050 UBERON:0002219 ! part of subfornical organ property_value: terms:contributor https://orcid.org/0000-0002-7073-9172 property_value: terms:date "2025-03-11T11:43:39Z" xsd:dateTime [Term] id: CL:0008044 name: tanycyte of area postrema def: "A tanycyte of the area postrema (AP). These cells extend long and slender fibers extending from their cell bodies in the ependyma toward fenestrated capillaries associated with the AP, where they form a dense network surrounding these capillaries." [PMID:23649873] subset: human_subset subset: mouse_subset synonym: "tanycyte-like cell of area postrema" EXACT [PMID:23649873] is_a: CL:0002085 ! tanycyte intersection_of: CL:0002085 ! tanycyte intersection_of: BFO:0000050 UBERON:0002162 ! part of area postrema relationship: BFO:0000050 UBERON:0002162 ! part of area postrema property_value: terms:contributor https://orcid.org/0000-0002-7073-9172 property_value: terms:date "2025-03-11T12:09:13Z" xsd:dateTime [Term] id: CL:0008045 name: tanycyte of subcommissural organ def: "A tanycyte of the subcommisural organ (SCO). These cells extend long and slender fibers extending from their cell bodies in the ependyma toward fenestrated capillaries associated with the SCO, where they form a dense network surrounding these capillaries." [PMID:23649873] subset: human_subset subset: mouse_subset synonym: "tanycyte-like cell of subcommissural organ" EXACT [PMID:23649873] is_a: CL:0002085 ! tanycyte intersection_of: CL:0002085 ! tanycyte intersection_of: BFO:0000050 UBERON:0002139 ! part of subcommissural organ relationship: BFO:0000050 UBERON:0002139 ! part of subcommissural organ property_value: terms:contributor https://orcid.org/0000-0002-7073-9172 property_value: terms:date "2025-03-11T12:09:34Z" xsd:dateTime [Term] id: CL:0008046 name: extrafusal muscle fiber def: "A skeletal muscle fiber that is innervated by alpha motor neuron and generates tension by contracting, thereby allowing for skeletal movement. These fibers make up the large mass of skeletal muscle tissue and are attached to bones by tendons." [DOI:10.1016/B978-0-443-10321-6.00004-7, Wikipedia:Extrafusal_muscle_fiber&oldid=978415293] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "myofibra extrafusalis" EXACT [] xref: TH:H3.03.00.0.00007 is_a: CL:0008002 ! skeletal muscle fiber disjoint_from: CL:0008047 ! intrafusal muscle fiber relationship: RO:0002103 CL:0008038 ! synapsed by alpha motor neuron property_value: terms:contributor https://orcid.org/0000-0002-7073-9172 creation_date: 2020-09-26T21:06:15Z [Term] id: CL:0008047 name: intrafusal muscle fiber def: "A skeletal muscle fiber that is part of a muscle spindle. These are specialized muscle fibers that serve as proprioceptors, detecting the amount and rate of change in length of a muscle. They are innervated by both sensory neurons and motor neurons (gamma and beta motorneurons, collectively referred to as fusimotor neurons)." [DOI:10.1016/B978-0-443-10321-6.00004-7, Wikipedia:Intrafusal_muscle_fiber&oldid=937508784] subset: human_subset subset: mouse_subset synonym: "myofibra intrafusalis" EXACT [] xref: TH:H3.03.00.0.00012 is_a: CL:0002319 ! neural cell is_a: CL:0008002 ! skeletal muscle fiber intersection_of: CL:0008002 ! skeletal muscle fiber intersection_of: BFO:0000050 UBERON:0003718 ! part of muscle spindle relationship: BFO:0000050 UBERON:0003718 ! part of muscle spindle property_value: terms:contributor https://orcid.org/0000-0002-7073-9172 creation_date: 2020-09-26T21:07:01Z [Term] id: CL:0008048 name: upper motor neuron def: "A glutamatergic motor neuron with a soma in the brainstem or cerebral cortex. They do not synapse directly to muscles but rather to lower motor neurons, which do. They are the main controllers of voluntary movement." [Wikipedia:Upper_motor_neuron&oldid=943248837] subset: human_subset subset: mouse_subset is_a: BFO:0000002 is_a: CL:0000100 ! motor neuron is_a: CL:0000679 ! glutamatergic neuron relationship: RO:0002120 CL:0008039 ! synapsed to lower motor neuron property_value: terms:contributor https://orcid.org/0000-0002-7073-9172 creation_date: 2020-09-28T09:41:48Z [Term] id: CL:0008049 name: Betz cell def: "A giant pyramidal neuron with a soma in layer Vb of the primary motor cortex that sends its axons down the spinal cord via the corticospinal tract, either synapsing directly with alpha motor neurons, or targeting interneurons in the spinal cord. In humans, Betz cells are the largest known in the central nervous system." [DOI:10.1101/2020.03.31.016972, Wikipedia:Betz_cell&oldid=977472330] subset: human_subset subset: mouse_subset synonym: "pyramidal cell of Betz" EXACT [] is_a: CL:2000049 ! primary motor cortex pyramidal cell is_a: CL:4023041 ! L5 extratelencephalic projecting glutamatergic cortical neuron relationship: RO:0000053 PATO:0070017 ! has characteristic standard pyramidal morphology relationship: RO:0002100 UBERON:0022315 ! has soma location primary motor cortex layer 5 relationship: RO:0002101 UBERON:0002707 ! fasciculates with corticospinal tract property_value: foaf:depiction "https://en.wikipedia.org/w/index.php?title=Betz_cell&oldid=977472330#/media/File:GolgiStainedPyramidalCell.jpg" xsd:string property_value: RO:0002175 NCBITaxon:9443 property_value: terms:contributor https://orcid.org/0000-0002-7073-9172 creation_date: 2020-09-28T09:52:58Z [Term] id: CL:0008053 name: circumventricular organ capillary endothelial cell def: "A capillary endothelial cell that is part of the circumventricular organs (CVOs), characterized by fenestrations that facilitate selective permeability to molecules, distinguishing it from the non-fenestrated endothelial cells of the blood-brain barrier. This cell is integral to the unique vascular structure of CVOs, which lack a traditional blood-brain barrier. It enables bidirectional exchange of polar molecules between blood and neural tissue, supporting neuroendocrine signaling, fluid balance, and immune responses. It is marked by the expression of PLVAP, a component of the fenestral diaphragm, in both rodents and humans." [PMID:26578857, PMID:35726097] subset: human_subset subset: mouse_subset is_a: CL:0000666 ! fenestrated endothelial cell is_a: CL:0002144 ! capillary endothelial cell is_a: CL:2000044 ! brain microvascular endothelial cell intersection_of: CL:0002144 ! capillary endothelial cell intersection_of: BFO:0000050 UBERON:0005408 ! part of circumventricular organ relationship: BFO:0000050 UBERON:0005408 ! part of circumventricular organ property_value: terms:contributor https://orcid.org/0000-0002-7073-9172 property_value: terms:date "2025-03-14T12:44:38Z" xsd:dateTime [Term] id: CL:0008055 name: respiratory tract secretory epithelial cell def: "A secretory epithelial cell of the respiratory tract epithelium. These cells have an endodermal origin." [DOI:10.1038/s41591-023-02327-2.] subset: human_subset subset: mouse_subset is_a: CL:0002368 ! respiratory tract epithelial cell is_a: CL:1100001 ! secretory epithelial cell intersection_of: CL:1100001 ! secretory epithelial cell intersection_of: BFO:0000050 UBERON:0004802 ! part of respiratory tract epithelium property_value: terms:contributor "https://orcid.org/0000-0002-7073-9172" xsd:string property_value: terms:date "2025-02-19T16:01:02Z" xsd:dateTime [Term] id: CL:0008059 name: GABA-Gly neuron def: "A neuron that releases both gamma-aminobutyric acid and glycine as vesicular neurotransmitters. Examples include types of amacrine cell and types of cerebellar inhibitory neurons." [PMID:18677503, PMID:37124720] subset: human_subset subset: mouse_subset is_a: CL:0000617 ! GABAergic neuron is_a: CL:1001509 ! glycinergic neuron intersection_of: CL:0000540 ! neuron intersection_of: RO:0002215 GO:0061534 ! capable of gamma-aminobutyric acid secretion, neurotransmission intersection_of: RO:0002215 GO:0061537 ! capable of glycine secretion, neurotransmission property_value: terms:contributor https://orcid.org/0000-0002-7073-9172 property_value: terms:date "2025-06-19T09:57:55Z" xsd:dateTime [Term] id: CL:0008060 name: GABA-Glut neuron def: "A neuron that releases both gamma-aminobutyric acid and glutamate as vesicular neurotransmitters." [PMID:29924991, PMID:37124720, PMID:38092916] subset: human_subset subset: mouse_subset is_a: CL:0000617 ! GABAergic neuron is_a: CL:0000679 ! glutamatergic neuron intersection_of: CL:0000540 ! neuron intersection_of: RO:0002215 GO:0061534 ! capable of gamma-aminobutyric acid secretion, neurotransmission intersection_of: RO:0002215 GO:0061535 ! capable of glutamate secretion, neurotransmission property_value: terms:contributor https://orcid.org/0000-0002-7073-9172 property_value: terms:date "2025-06-19T10:06:06Z" xsd:dateTime [Term] id: CL:0008061 name: GABA-Chol neuron def: "A neuron that releases both gamma-aminobutyric acid and acetylcholine as vesicular neurotransmitters. Examples include some types of striatal interneuron." [PMID:29651049] subset: human_subset subset: mouse_subset is_a: CL:0000108 ! cholinergic neuron is_a: CL:0000617 ! GABAergic neuron intersection_of: CL:0000540 ! neuron intersection_of: RO:0002215 GO:0014055 ! capable of acetylcholine secretion, neurotransmission intersection_of: RO:0002215 GO:0061534 ! capable of gamma-aminobutyric acid secretion, neurotransmission property_value: terms:contributor https://orcid.org/0000-0002-7073-9172 property_value: terms:date "2025-06-19T10:13:06Z" xsd:dateTime [Term] id: CL:0009000 name: sensory neuron of spinal nerve def: "A sensory neuron of the spinal nerve that senses body position and sends information about how much the muscle is stretched to the spinal cord." [GOC:nv, GOC:pr] subset: human_subset subset: mouse_subset synonym: "spinal sensory neuron" EXACT [] is_a: CL:3000004 ! peripheral sensory neuron intersection_of: CL:0000101 ! sensory neuron intersection_of: RO:0002100 UBERON:0001780 ! has soma location spinal nerve relationship: RO:0002100 UBERON:0001780 ! has soma location spinal nerve [Term] id: CL:0009001 name: compound eye retinal cell def: "Any cell in the compound eye, a light sensing organ composed of ommatidia." [] xref: GOC:pr xref: PMID:12021768 is_a: CL:0009004 ! retinal cell [Term] id: CL:0009002 name: inflammatory cell def: "Any cell participating in the inflammatory response to a foreign substance, e.g. neutrophil, macrophage." [] subset: cellxgene_subset subset: human_subset subset: mouse_subset xref: GOC:pr xref: http://en.wikipedia.org/wiki/Inflammatory_response is_a: CL:0000000 ! cell relationship: RO:0002216 GO:0006954 ! capable of part of inflammatory response [Term] id: CL:0009003 name: larval midgut cell def: "Any cell in the midgut (middle subdivision of a digestive tract) of an insect larva." [] xref: GOC:pr xref: http://en.wikipedia.org/wiki/Insect#Midgut is_a: CL:0000255 ! eukaryotic cell relationship: BFO:0000050 UBERON:0001555 ! part of digestive tract relationship: BFO:0000050 UBERON:0002548 ! part of larva relationship: RO:0002162 NCBITaxon:50557 ! in taxon Insecta property_value: seeAlso "https://github.com/obophenotype/cell-ontology/issues/710" xsd:string [Term] id: CL:0009004 name: retinal cell def: "Any cell in the retina, the innermost layer or coating at the back of the eyeball, which is sensitive to light and in which the optic nerve terminates." [GOC:pr] subset: cellxgene_subset subset: human_subset subset: mouse_subset xref: PMID:10702418 is_a: CL:0002319 ! neural cell intersection_of: CL:0002319 ! neural cell intersection_of: BFO:0000050 UBERON:0005388 ! part of photoreceptor array relationship: BFO:0000050 UBERON:0005388 ! part of photoreceptor array property_value: skos:prefLabel "retinal cell" xsd:string [Term] id: CL:0009005 name: salivary gland cell def: "Any cell in a salivary gland." [] subset: cellxgene_subset subset: human_subset subset: mouse_subset xref: GOC:pr xref: http://en.wikipedia.org/wiki/Salivary_gland is_a: CL:0000255 ! eukaryotic cell relationship: BFO:0000050 UBERON:0001044 ! part of saliva-secreting gland [Term] id: CL:0009006 name: enteroendocrine cell of small intestine def: "An enteroendocrine cell that is located in the small intestine." [http://orcid.org/0000-0003-3440-1876] subset: cellxgene_subset subset: human_subset subset: location_grouping subset: mouse_subset synonym: "small intestine enteroendocrine cell" EXACT [] is_a: CL:1001516 ! intestinal enteroendocrine cell is_a: CL:1001598 ! small intestine secretory cell intersection_of: CL:0000164 ! enteroendocrine cell intersection_of: BFO:0000050 UBERON:0002108 ! part of small intestine property_value: foaf:depiction http://purl.obolibrary.org/obo/cl/images/Small-intestine-cells.png {dc:license="http://creativecommons.org/licenses/by/4.0/", xref="doi:10.1186/s13619-020-00061-5", comment="Figure depicts a cross section of intestinal villi in the small intestine, including the crypts of Lieberkuhn (seen here as ‘crypt’), as well as the layer specific locations of cells that exist within the gastrointestinal tract. Layers depicted here include epithelium (rows of cells bordering villus), submucosa (white space below the epithelium containing networks of neurons and ganglia depicted in pink), muscularis mucosae (blue layer), muscularis propria (referred to here as muscle layer).\n\nISC: Intestinal Stem Cell \nTA: Transit Amplifying Cells"} property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0009006" xsd:string {name="enteroendocrine cell of small intestine on CELLxGENE CellGuide"} property_value: terms:contributor https://orcid.org/0000-0002-2825-0621 property_value: terms:description "The enteroendocrine cell of the small intestine is a specialized type of cell that forms part of the lining of the intestinal wall. These cells are interspersed among absorptive cells, mucus-secreting goblet cells, and other gut cell types, forming the crypt-villus axis, which is the functional unit of the small intestinal epithelium. \nFunctionally, enteroendocrine cells play a pivotal role in the gut-endocrine system, which is responsible for the digestive process. These cells translate the luminal nutrient status into hormonal signals thereby acting as chemosensors. They contain secretory granules at their base which release hormones into the bloodstream following chemo-sensation. The hormones they secrete perform diverse functions including regulating gastric secretion, gut motility, insulin release, appetite control and other local and systemic effects. \nIn addition to their endocrine functions, enteroendocrine cells also play a part in the modulation of the immune response in the gut. They can secrete cytokines and chemokines that have a role in directing the immune response to invading pathogens. Moreover, emerging research suggests that these cells play a role in maintaining the balance between gut resident bacteria, known as the gut microbiota, and the host. As such, a comprehensive understanding of the enteroendocrine cells of the small intestine underpins knowledge in nutrition, endocrinology, and various gastroenterological conditions.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1016/j.coph.2013.09.008", xref="DOI:10.1038/mi.2017.73", xref="DOI:10.1038/nature24489", xref="DOI:10.1111/j.1365-2613.2011.00767.x", xref="DOI:10.1146/annurev-physiol-021115-105439"} [Term] id: CL:0009007 name: gastrointestinal tract (lamina propria) macrophage of small intestine def: "A macrophage which is resident in the lamina propria of the small intestine." [https://orcid.org/0000-0003-4183-8865] subset: human_subset subset: location_grouping subset: mouse_subset synonym: "macrophage of small intestine" BROAD [] synonym: "small intestine lamina propria resident macrophage" EXACT [] is_a: CL:0000865 ! gastrointestinal tract (lamina propria) macrophage intersection_of: CL:0000885 ! gut-associated lymphoid tissue macrophage intersection_of: BFO:0000050 UBERON:0001238 ! part of lamina propria of small intestine relationship: BFO:0000050 UBERON:0001238 ! part of lamina propria of small intestine property_value: terms:contributor https://orcid.org/0000-0002-2825-0621 [Term] id: CL:0009008 name: gastrointestinal tract (lamina propria) macrophage of large intestine def: "A macrophage which is resident in the lamina propria of the large intestine." [https://orcid.org/0000-0003-4183-8865] subset: cellxgene_subset subset: human_subset subset: location_grouping subset: mouse_subset synonym: "large intestine lamina propria resident macrophage" EXACT [] synonym: "macrophage of large intestine" BROAD [] is_a: CL:0000865 ! gastrointestinal tract (lamina propria) macrophage intersection_of: CL:0000885 ! gut-associated lymphoid tissue macrophage intersection_of: BFO:0000050 UBERON:0011189 ! part of lamina propria of large intestine relationship: BFO:0000050 UBERON:0011189 ! part of lamina propria of large intestine property_value: terms:contributor https://orcid.org/0000-0002-2825-0621 [Term] id: CL:0009009 name: paneth cell of colon def: "A paneth cell that is located in the epithelium of the colon." [http://orcid.org/0000-0003-4183-8865, PMID:31753849] subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: location_grouping subset: mouse_subset synonym: "paneth cell of epithelium of colon" EXACT [] synonym: "paneth cell of epithelium of large intestine" BROAD [] synonym: "paneth-like cell" EXACT [] is_a: CL:0000510 ! paneth cell is_a: CL:1001588 ! colon glandular cell intersection_of: CL:0000510 ! paneth cell intersection_of: BFO:0000050 UBERON:0000397 ! part of colonic epithelium property_value: RO:0002175 NCBITaxon:9606 property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0009009" xsd:string {name="paneth cell of colon on CELLxGENE CellGuide"} property_value: terms:contributor https://orcid.org/0000-0002-2825-0621 property_value: terms:description "Paneth cells of the colon are specialized secretory epithelial cells that can be found in the large intestine, albeit in small numbers compared with the small intestine where Paneth cells are more abundant. Under disease conditions such as inflammatory bowel disease, Paneth cells increase in numbers in the colon. They reside in the crypts of Lieberkühn, which are glandular structures embedded within the mucosal layer of the small and large intestine. \nPaneth cells play a crucial role in maintaining intestinal homeostasis and acting as a frontline of defense in our bodies against ingested microbes. They achieve this through the secretion of antimicrobial peptides and proteins such as lysozyme and defensins, which can directly kill or inhibit the growth of various bacteria, fungi, and viruses. They degranulate these substances into the intestinal lumen, especially under conditions of pathogenic invasion or damage to the epithelial lining. \nMoreover, Paneth cells are essential for the maintenance of intestinal stem cells, which continually replace the epithelium of the intestine. They create a niche for these stem cells at the base of the crypts, secreting various signaling molecules and factors that are essential for the growth and differentiation of intestinal stem cells. In essence, the existence and function of Paneth cells are fundamental to the overall gut health and immune defense system, by providing both antimicrobial functions and a conducive environment for the renewal of the intestinal lining. \nThe role of Paneth cells specifically in the colon is of interest in the context of inflammatory bowel disease, such as ulcerative colitis and Crohn’s disease: Their presence in the colon is thought to represent Paneth cell metaplasia and indicates a chronic inflammatory state.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1002/ibd.20197", xref="DOI:10.1038/nature09637", xref="DOI:10.1038/nrmicro2546", xref="DOI:10.1093/ecco-jcc/jjac190.0884", xref="DOI:10.1136/gut.48.2.176"} [Term] id: CL:0009010 name: transit amplifying cell def: "Transit-amplifying cells (TACs) are an undifferentiated population in transition between stem cells and differentiated cells." [http://orcid.org/0000-0003-4183-8865, PMID:24813615, PMID:28835754] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "TAC" RELATED [] synonym: "TACs" RELATED [] synonym: "transient amplifying cell" EXACT [] synonym: "transit amplifying progenitor cell" EXACT [PMID:30827895] synonym: "transit-amplifying cell" EXACT [] is_a: BFO:0000002 is_a: CL:0000255 ! eukaryotic cell relationship: RO:0002202 CL:0000034 ! develops from stem cell property_value: terms:contributor https://orcid.org/0000-0002-2825-0621 [Term] id: CL:0009011 name: transit amplifying cell of colon def: "A rapidly proliferating population of cells that differentiate from stem cells of the intestinal crypt of the colon. Stem cells located in the crypts of Lieberkühn give rise to proliferating progenitor or transit amplifying cells that differentiate into the four major epithelial cell types. These include columnar absorptive cells or enterocytes, mucous secreting goblet cells, enteroendocrine cells and paneth cells." [http://orcid.org/0000-0003-4183-8865, PMID:20801415] subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: location_grouping subset: mouse_subset synonym: "colon transit amplifying cell" EXACT [] synonym: "transient amplifying cell of colon" EXACT [] synonym: "transient amplifying cell of crypt of Lieberkuhn of colon" EXACT [] synonym: "transit amplifying cell of crypt of Lieberkuhn of colon" EXACT [] synonym: "transit amplifying cell of large intestine" BROAD [] synonym: "transit-amplifying cell of colon" EXACT [] is_a: CL:0002253 ! epithelial cell of large intestine is_a: CL:4047017 ! transit amplifying cell of gut intersection_of: CL:4047017 ! transit amplifying cell of gut intersection_of: BFO:0000050 UBERON:0013485 ! part of crypt of Lieberkuhn of colon relationship: BFO:0000050 UBERON:0013485 ! part of crypt of Lieberkuhn of colon property_value: RO:0002175 NCBITaxon:9606 property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0009011" xsd:string {name="transit amplifying cell of colon on CELLxGENE CellGuide"} property_value: terms:contributor https://orcid.org/0000-0002-2825-0621 property_value: terms:description "Transit amplifying cells (TACs) are an intermediate, undifferentiated population between stem cells and differentiated cells. They can be found in multiple regions such as the small intestine and the colon. TACs of the colon, are integral components of the colonic crypts and vital players in the maintenance of colonic tissue. \nThese cells serve a critical function in the rapid and constant renewal of the epithelium lining the colon, with the whole epithelial surface renewed approximately every 5-7 days. They divide rapidly and progressively differentiate into mature columnar epithelium cells, including enterocytes, goblet cells, and enteroendocrine cells. The continued proliferation of transit amplifying cells is fundamental to maintain the balance in cell population while preventing tissue degeneration and maintaining a state of homeostasis. However, uncontrolled proliferation and compromised differentiation capacity can contribute to the development of colon cancers.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1016/j.cell.2014.02.057", xref="DOI:10.1053/j.gastro.2018.08.016", xref="DOI:10.1172/jci.insight.150894", xref="DOI:10.3389/fbioe.2023.1189225", xref="https://www.sciencedirect.com/topics/immunology-and-microbiology/intestinal-stem-cell"} [Term] id: CL:0009012 name: transit amplifying cell of small intestine def: "A rapidly proliferating population of cells that differentiate from stem cells of the intestinal crypt of the small intestine. Stem cells located in the crypts of Lieberkühn give rise to proliferating progenitor or transit amplifying cells that differentiate into the four major epithelial cell types. These include columnar absorptive cells or enterocytes, mucous secreting goblet cells, enteroendocrine cells and paneth cells." [http://orcid.org/0000-0003-4183-8865, PMID:20801415] subset: cellxgene_subset subset: human_subset subset: location_grouping subset: mouse_subset synonym: "small intestine transit amplifying cell" EXACT [] synonym: "transient amplifying cell of crypt of Lieberkuhn of small intestine" EXACT [] synonym: "transient amplifying cell of small intestine" EXACT [] synonym: "transit amplifying cell of crypt of Lieberkuhn of small intestine" EXACT [] synonym: "transit-amplifying cell of small intestine" EXACT [] is_a: CL:0002254 ! epithelial cell of small intestine is_a: CL:4047017 ! transit amplifying cell of gut intersection_of: CL:4047017 ! transit amplifying cell of gut intersection_of: BFO:0000050 UBERON:0001241 ! part of crypt of Lieberkuhn of small intestine relationship: BFO:0000050 UBERON:0001241 ! part of crypt of Lieberkuhn of small intestine property_value: foaf:depiction http://purl.obolibrary.org/obo/cl/images/Small-intestine-cells.png {dc:license="http://creativecommons.org/licenses/by/4.0/", comment="Figure depicts a cross section of intestinal villi in the small intestine , including the crypts of Lieberkhun (seen here as ‘crypt’), as well as the layer specific locations of cells that exist within the gastrointestinal tract. Layers depicted here include epithelium (rows of cells bordering villus), submucosa (white space below the epithelium containing networks of neurons and ganglia depicted in pink), muscularis mucosae (blue layer), muscularis propria (referred to here as muscle layer).\n\nISC: Intestinal Stem Cell \nTA: Transit Amplifying Cells"} property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0009012" xsd:string {name="transit amplifying cell of small intestine on CELLxGENE CellGuide"} property_value: terms:contributor https://orcid.org/0000-0002-2825-0621 property_value: terms:description "Transit amplifying cells (TACs) represent an intermediate population between stem cells and fully differentiated cells, and can be found in multiple regions such as the colon and the small intestine. The small intestine's efficiency in absorbing nutrients, its protective barrier function, and its innate cellular renewal every few days is largely dependent on the role played by these TACs.\nTACs of the small intestine are primarily present in the crypt-villus structure of the intestine, more specifically in the crypt region. They originate from Lgr5+ intestinal stem cells that reside at the base of the crypts. Following their derivation from stem cells, TACs undergo up to six rounds of rapid division over a 48-72 hour period, effectively amplifying the cell population, hence their name. During this process, they gradually migrate upward along the walls of the crypt from where they differentiate into diverse mature cell types such as enterocytes, goblet cells, and Paneth cells. \nTACs serve as an important element in the homeostasis and regeneration of the intestinal epithelium, amplifying the pool of cells available for differentiation. They also minimize genetic errors during DNA replication by serving as a 'buffer zone' between the long-lived stem cells and the terminal differentiated cells of the gut lining, thus reducing the potential for propagation of mutation-causing defects. Lastly, TACs play an essential part in gastrointestinal tissue repair following injury or inflammation. Their rapid proliferation and subsequent differentiation abilities often help expedite the wound healing process in the intestinal epithelium.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1007/s11894-010-0130-3", xref="DOI:10.1016/j.cell.2014.02.057", xref="DOI:10.1101/gad.1674008"} [Term] id: CL:0009013 name: fetal hepatobiliary progenitor cell def: "A progenitor cell with hepatic and biliary lineage potential, identified in mouse and human, and anatomically restricted to the ductal plate of fetal liver." [https://orcid.org/0000-0002-3163-0115, PMID:31350390] subset: added_for_HCA subset: human_subset subset: mouse_subset synonym: "fetal hepatobiliary hybrid progenitor cell" EXACT [] synonym: "HHyP cell" EXACT [] is_a: CL:0011026 ! progenitor cell relationship: BFO:0000050 UBERON:8410003 ! part of ductal plate relationship: RO:0002162 NCBITaxon:40674 ! in taxon Mammalia property_value: terms:contributor https://orcid.org/0000-0002-2825-0621 [Term] id: CL:0009014 name: Peyer's patch lymphocyte def: "A lymphocyte that is part of a Peyer's patch. These cells have a major role in driving the immune response to antigens sampled from the intestinal lumen, and in regulating the formation of follicle-associated epithelium and M cells in Peyer's patches by converting intestitial enterocytes into M cells." [https://orcid.org/0000-0003-4183-8865, PMID:23525039, PMID:9252325] subset: human_subset subset: location_grouping subset: mouse_subset synonym: "Peyer's patch resident lymphocyte" EXACT [] synonym: "small intestine Peyer's patch lymphocyte" NARROW [] is_a: CL:0000542 ! lymphocyte intersection_of: CL:0000542 ! lymphocyte intersection_of: BFO:0000050 UBERON:0001211 ! part of Peyer's patch relationship: BFO:0000050 UBERON:0001211 ! part of Peyer's patch property_value: terms:contributor https://orcid.org/0000-0002-2825-0621 [Term] id: CL:0009015 name: Peyer's patch follicular dendritic cell def: "A follicular dendritic cell located in the Peyer's patch. These cells from a meshwork in which Peyer's patch B cells reside." [https://orcid.org/0000-0003-4183-8865, PMID:24437401] subset: human_subset subset: location_grouping subset: mouse_subset is_a: CL:0000442 ! follicular dendritic cell intersection_of: CL:0000442 ! follicular dendritic cell intersection_of: BFO:0000050 UBERON:0001211 ! part of Peyer's patch relationship: BFO:0000050 UBERON:0001211 ! part of Peyer's patch property_value: terms:contributor https://orcid.org/0000-0002-2825-0621 [Term] id: CL:0009016 name: intestinal crypt stem cell of large intestine def: "An intestinal stem cell that is located in the large intestine crypt of Liberkuhn. These stem cells reside at the bottom of crypts in the large intestine and are highly proliferative. They either differentiate into transit amplifying cells or self-renew to form new stem cells." [https://orcid.org/0000-0003-4183-8865, PMID:20683682] subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: location_grouping subset: mouse_subset synonym: "crypt stem cell of large intestine" BROAD [] synonym: "stem cell of large intestine crypt of Lieberkuhn" EXACT [] is_a: CL:0002250 ! intestinal crypt stem cell is_a: CL:0002253 ! epithelial cell of large intestine intersection_of: CL:0002250 ! intestinal crypt stem cell intersection_of: BFO:0000050 UBERON:0001984 ! part of crypt of Lieberkuhn of large intestine relationship: BFO:0000050 UBERON:0001984 ! part of crypt of Lieberkuhn of large intestine property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/2d-ftu/large-intestine-crypt-lieberkuhn/v1.2/assets/2d-ftu-large-intestine-crypt-lieberkuhn.png" xsd:string {terms:licence="http://creativecommons.org/licenses/by/4.0/", xref="doi:10.48539/HBM294.HJJZ.279"} property_value: RO:0002175 NCBITaxon:9606 property_value: terms:contributor https://orcid.org/0000-0002-2825-0621 [Term] id: CL:0009017 name: intestinal crypt stem cell of small intestine def: "An intestinal stem cell that is located in the small intestine crypt of Liberkuhn. These stem cells reside at the bottom of crypts in the small intestine and are highly proliferative. They either differentiate into transit amplifying cells or self-renew to form new stem cells." [https://orcid.org/0000-0003-4183-8865, PMID:20683682] subset: cellxgene_subset subset: human_subset subset: location_grouping subset: mouse_subset synonym: "crypt stem cell of small intestine" BROAD [] synonym: "stem cell of small intestine crypt of Lieberkuhn" EXACT [] is_a: CL:0002250 ! intestinal crypt stem cell is_a: CL:0002254 ! epithelial cell of small intestine intersection_of: CL:0002250 ! intestinal crypt stem cell intersection_of: BFO:0000050 UBERON:0001241 ! part of crypt of Lieberkuhn of small intestine relationship: BFO:0000050 UBERON:0001241 ! part of crypt of Lieberkuhn of small intestine property_value: foaf:depiction http://purl.obolibrary.org/obo/cl/images/Small-intestine-cells.png {dc:license="http://creativecommons.org/licenses/by/4.0/", xref="doi:10.1186/s13619-020-00061-5", comment="Figure depicts a cross section of intestinal villi in the small intestine, including the crypts of Lieberkuhn (seen here as ‘crypt’), as well as the layer specific locations of cells that exist within the gastrointestinal tract. Layers depicted here include epithelium (rows of cells bordering villus), submucosa (white space below the epithelium containing networks of neurons and ganglia depicted in pink), muscularis mucosae (blue layer), muscularis propria (referred to here as muscle layer).\n\nISC: Intestinal Stem Cell \nTA: Transit Amplifying Cells"} property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0009017" xsd:string {name="intestinal crypt stem cell of small intestine on CELLxGENE CellGuide"} property_value: terms:contributor https://orcid.org/0000-0002-2825-0621 property_value: terms:description "Intestinal crypt stem cells of the small intestine are a type of adult stem cell intimately involved in the continuous replenishment of the intestinal epithelium, the innermost layer of the intestine responsible for nutrient absorption. These cells, located within the crypts of Lieberkühn, are the origin of various cell lineages that make up the functional units of the small intestine. They possess self-renewal ability, an essential feature of stem cells, which allows them to maintain a steady population in the small intestine.\nOne of the critical roles of intestinal crypt stem cells is to drive the continual renewal process taking place in the small intestine every 3-5 days. By proliferating intensively, these cells produce transient amplifying (TA) cells that are characterized by quick division and progressive differentiation. These cells eventually differentiate into specialized cell types, encompassing absorptive enterocytes, mucin-secreting goblet cells, hormone-secreting enteroendocrine cells, and Paneth cells, all of which have essential roles in digestion and nutrient absorption in the small intestine.\nIntestinal crypt stem cells of the small intestine are also play a significant part in injury recovery. Under regular conditions, these cells primarily exist in an active state, facilitating the constant renovation of the gut lining. However, upon injury or loss of regular intestinal crypt stem cells reserve intestinal stem cells, a slow-cycling and radio-resistant population, can be stimulated to take over the duties of active crypt stem cells. Such plasticity provides a powerful regenerative mechanism that ensures the intestinal epithelium's function and structural integrity amidst diverse conditions.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1016/j.celrep.2020.107952", xref="DOI:10.1038/s41575-018-0081-y", xref="DOI:10.1073/pnas.1607327113"} [Term] id: CL:0009018 name: lymphocyte of large intestine lamina propria def: "A lymphocyte that resides in the lamina propria of the large intestine." [https://orcid.org/0000-0003-4183-8865] comment: This is a general grouping term created for use in the EMBL-EBI Single Cell Expression Atlas anatomograms. Please use a more specific cell type term for annotation if possible, given the information available to you. subset: human_reference_atlas subset: human_subset subset: location_grouping subset: mouse_subset synonym: "lamina propria lymphocyte of large intestine" EXACT [] is_a: CL:0000542 ! lymphocyte intersection_of: CL:0000542 ! lymphocyte intersection_of: BFO:0000050 UBERON:0011189 ! part of lamina propria of large intestine relationship: BFO:0000050 UBERON:0011189 ! part of lamina propria of large intestine property_value: RO:0002175 NCBITaxon:9606 property_value: terms:contributor https://orcid.org/0000-0002-2825-0621 [Term] id: CL:0009019 name: nephrogenic zone cell def: "A kidney cortical cell that is part of the nephrogenic zone." [https://orcid.org/0000-0002-3163-0115, PMID:29449449] subset: added_for_HCA subset: human_subset subset: mouse_subset synonym: "cortical nephrogenic niche cell" EXACT [] synonym: "cortical nephrogenic zone cell" EXACT [] is_a: CL:0002681 ! kidney cortical cell intersection_of: CL:0002681 ! kidney cortical cell intersection_of: BFO:0000050 UBERON:0009871 ! part of nephrogenic zone relationship: BFO:0000050 UBERON:0009871 ! part of nephrogenic zone property_value: terms:contributor https://orcid.org/0000-0002-2825-0621 [Term] id: CL:0009020 name: tuft cell of appendix def: "An intestinal tuft cell that is a part of a vermiform appendix." [http://orcid.org/0000-0003-3440-1876] subset: human_subset subset: location_grouping subset: mouse_subset synonym: "appendix tuft cell" EXACT [] synonym: "tuft cell of appendix vermiformis" EXACT [] synonym: "tuft cell of vermiform appendix" EXACT [] is_a: CL:0002203 ! tuft cell of large intestine intersection_of: CL:0019032 ! intestinal tuft cell intersection_of: BFO:0000050 UBERON:0001154 ! part of vermiform appendix relationship: BFO:0000050 UBERON:0001154 ! part of vermiform appendix property_value: terms:contributor https://orcid.org/0000-0002-2825-0621 [Term] id: CL:0009021 name: stromal cell of lamina propria of large intestine def: "A stromal cell found in the lamina propria of the large intestine." [http://orcid.org/0000-0003-4183-8865] subset: human_subset subset: location_grouping subset: mouse_subset is_a: CL:0000499 ! stromal cell intersection_of: CL:0000499 ! stromal cell intersection_of: BFO:0000050 UBERON:0011189 ! part of lamina propria of large intestine relationship: BFO:0000050 UBERON:0011189 ! part of lamina propria of large intestine property_value: terms:contributor https://orcid.org/0000-0002-2825-0621 [Term] id: CL:0009022 name: stromal cell of lamina propria of small intestine def: "A stromal cell found in the lamina propria of the small intestine." [http://orcid.org/0000-0003-4183-8865] subset: cellxgene_subset subset: human_subset subset: location_grouping subset: mouse_subset is_a: CL:0000499 ! stromal cell intersection_of: CL:0000499 ! stromal cell intersection_of: BFO:0000050 UBERON:0001238 ! part of lamina propria of small intestine relationship: BFO:0000050 UBERON:0001238 ! part of lamina propria of small intestine property_value: terms:contributor https://orcid.org/0000-0002-2825-0621 [Term] id: CL:0009023 name: small intestine Peyer's patch T cell def: "A T cell which resides in the Peyer's patch of the small intestine." [http://orcid.org/0000-0003-4183-8865] subset: human_subset subset: location_grouping subset: mouse_subset synonym: "T cell of Peyer's patch of small intestine" EXACT [] synonym: "T cell of small intestine Peyer's patch" EXACT [] is_a: CL:0002419 ! mature T cell is_a: CL:0009014 ! Peyer's patch lymphocyte intersection_of: CL:0002419 ! mature T cell intersection_of: BFO:0000050 UBERON:0003454 ! part of small intestine Peyer's patch relationship: BFO:0000050 UBERON:0003454 ! part of small intestine Peyer's patch property_value: terms:contributor https://orcid.org/0000-0002-2825-0621 [Term] id: CL:0009024 name: mesothelial cell of small intestine def: "A mesothelial cell that is part of the small intestine." [http://orcid.org/0000-0003-4183-8865] subset: human_subset subset: location_grouping subset: mouse_subset is_a: CL:0008041 ! mesothelial cell of intestine intersection_of: CL:0000077 ! mesothelial cell intersection_of: BFO:0000050 UBERON:0001206 ! part of serosa of small intestine relationship: BFO:0000050 UBERON:0001206 ! part of serosa of small intestine property_value: terms:contributor https://orcid.org/0000-0002-2825-0621 [Term] id: CL:0009025 name: mesothelial cell of colon def: "A mesothelial cell that is part of the colon." [http://orcid.org/0000-0003-3440-1876, http://orcid.org/0000-0003-4183-8865] subset: human_subset subset: location_grouping subset: mouse_subset synonym: "mesothelial cell of large intestine" BROAD [] is_a: CL:0008041 ! mesothelial cell of intestine intersection_of: CL:0000077 ! mesothelial cell intersection_of: BFO:0000050 UBERON:0003335 ! part of serosa of colon relationship: BFO:0000050 UBERON:0003335 ! part of serosa of colon property_value: terms:contributor https://orcid.org/0000-0002-2825-0621 [Term] id: CL:0009026 name: enterocyte of appendix def: "An enterocyte that is a part of a vermiform appendix." [http://orcid.org/0000-0003-3440-1876] subset: human_subset subset: location_grouping subset: mouse_subset synonym: "appendix enterocyte" EXACT [] synonym: "enterocyte of appendix vermiformis" EXACT [] synonym: "enterocyte of vermiform appendix" EXACT [] is_a: CL:0002071 ! enterocyte of epithelium of large intestine is_a: CL:1000405 ! epithelial cell of appendix intersection_of: CL:0000584 ! enterocyte intersection_of: BFO:0000050 UBERON:0001154 ! part of vermiform appendix property_value: terms:contributor https://orcid.org/0000-0002-2825-0621 [Term] id: CL:0009027 name: transit amplifying cell of appendix def: "A transit amplifying cell that is part of a crypt of Lieberkuhn of large intestine." [http://orcid.org/0000-0003-3440-1876] subset: human_subset subset: location_grouping subset: mouse_subset synonym: "appendix transit amplifying cell" EXACT [] synonym: "transit amplifying cell of appendix vermiformis" EXACT [] synonym: "transit amplifying cell of vermiform appendix" EXACT [] is_a: CL:0002253 ! epithelial cell of large intestine is_a: CL:4047017 ! transit amplifying cell of gut intersection_of: CL:4047017 ! transit amplifying cell of gut intersection_of: BFO:0000050 UBERON:0013486 ! part of crypt of Lieberkuhn of appendix relationship: BFO:0000050 UBERON:0013486 ! part of crypt of Lieberkuhn of appendix relationship: RO:0002202 CL:0009028 ! develops from intestinal crypt stem cell of appendix property_value: terms:contributor https://orcid.org/0000-0002-2825-0621 [Term] id: CL:0009028 name: intestinal crypt stem cell of appendix def: "An intestinal crypt stem cell that is located in the vermiform appendix. These stem cells reside at the bottom of crypts in the appendix and are highly proliferative. They either differentiate into transit amplifying cells or self-renew to form new stem cells." [http://orcid.org/0000-0003-3440-1876, PMID:20683682] subset: human_subset subset: location_grouping subset: mouse_subset synonym: "appendix intestinal crypt stem cell" EXACT [] synonym: "intestinal crypt stem cell of appendix vermiformis" EXACT [] synonym: "intestinal crypt stem cell of vermiform appendix" EXACT [] synonym: "stem cell of intestinal crypt of Lieberkuhn of appendix" EXACT [] synonym: "stem cell of intestinal crypt of Lieberkuhn of appendix vermiformis" EXACT [] is_a: CL:0009016 ! intestinal crypt stem cell of large intestine intersection_of: CL:0002250 ! intestinal crypt stem cell intersection_of: BFO:0000050 UBERON:0013486 ! part of crypt of Lieberkuhn of appendix relationship: BFO:0000050 UBERON:0013486 ! part of crypt of Lieberkuhn of appendix property_value: terms:contributor https://orcid.org/0000-0002-2825-0621 [Term] id: CL:0009029 name: mesothelial cell of appendix def: "A mesothelial cell that is located in a vermiform appendix." [http://orcid.org/0000-0003-3440-1876] subset: human_subset subset: location_grouping subset: mouse_subset synonym: "appendix mesothelial cell" EXACT [] synonym: "mesothelial cell of appendix vermiformis" EXACT [] synonym: "mesothelial cell of vermiform appendix" EXACT [] is_a: CL:0008041 ! mesothelial cell of intestine intersection_of: CL:0000077 ! mesothelial cell intersection_of: BFO:0000050 UBERON:0012498 ! part of serosa of appendix relationship: BFO:0000050 UBERON:0012498 ! part of serosa of appendix property_value: terms:contributor https://orcid.org/0000-0002-2825-0621 [Term] id: CL:0009030 name: enteroendocrine cell of appendix def: "An intestinal enteroendocrine cell that is located in a vermiform appendix." [http://orcid.org/0000-0003-3440-1876] subset: human_subset subset: location_grouping subset: mouse_subset synonym: "appendix enteroendocrine cell" EXACT [] synonym: "enteroendocrine cell of appendix vermiformis" EXACT [] synonym: "enteroendocrine cell of vermiform appendix" EXACT [] is_a: CL:1000405 ! epithelial cell of appendix is_a: CL:1001516 ! intestinal enteroendocrine cell intersection_of: CL:1001516 ! intestinal enteroendocrine cell intersection_of: BFO:0000050 UBERON:0001154 ! part of vermiform appendix property_value: terms:contributor https://orcid.org/0000-0002-2825-0621 [Term] id: CL:0009031 name: T cell of appendix def: "A T cell that is located in a vermiform appendix." [http://orcid.org/0000-0003-3440-1876] comment: This is a general grouping term created for use in the EMBL-EBI Single Cell Expression Atlas anatomograms. Please use a more specific cell type term for annotation if possible, given the information available to you. subset: human_subset subset: location_grouping subset: mouse_subset synonym: "appendix T cell" EXACT [] synonym: "T cell of appendix vermiformis" EXACT [] synonym: "T cell of vermiform appendix" EXACT [] is_a: CL:0000084 ! T cell intersection_of: CL:0000084 ! T cell intersection_of: BFO:0000050 UBERON:0001154 ! part of vermiform appendix relationship: BFO:0000050 UBERON:0001154 ! part of vermiform appendix property_value: terms:contributor https://orcid.org/0000-0002-2825-0621 [Term] id: CL:0009032 name: B cell of appendix def: "A B cell that is located in a vermiform appendix." [http://orcid.org/0000-0003-3440-1876] comment: This is a general grouping term created for use in the EMBL-EBI Single Cell Expression Atlas anatomograms. Please use a more specific cell type term for annotation if possible, given the information available to you. subset: human_subset subset: location_grouping subset: mouse_subset synonym: "appendix B cell" EXACT [] synonym: "B cell of appendix vermiformis" EXACT [] synonym: "B cell of vermiform appendix" EXACT [] is_a: CL:0000236 ! B cell intersection_of: CL:0000236 ! B cell intersection_of: BFO:0000050 UBERON:0001154 ! part of vermiform appendix relationship: BFO:0000050 UBERON:0001154 ! part of vermiform appendix property_value: terms:contributor https://orcid.org/0000-0002-2825-0621 [Term] id: CL:0009033 name: plasma cell of appendix def: "A plasma cell that is located in a vermiform appendix." [http://orcid.org/0000-0003-3440-1876] comment: This is a general grouping term created for use in the EMBL-EBI Single Cell Expression Atlas anatomograms. Please use a more specific cell type term for annotation if possible, given the information available to you. subset: human_subset subset: location_grouping subset: mouse_subset synonym: "appendix plasma cell" EXACT [] synonym: "plasma cell of appendix vermiformis" EXACT [] synonym: "plasma cell of vermiform appendix" EXACT [] is_a: CL:0000786 ! plasma cell intersection_of: CL:0000786 ! plasma cell intersection_of: BFO:0000050 UBERON:0001154 ! part of vermiform appendix relationship: BFO:0000050 UBERON:0001154 ! part of vermiform appendix property_value: terms:contributor https://orcid.org/0000-0002-2825-0621 [Term] id: CL:0009034 name: dendritic cell of appendix def: "A dendritic cell that is located in a vermiform appendix." [http://orcid.org/0000-0003-3440-1876] comment: This is a general grouping term created for use in the EMBL-EBI Single Cell Expression Atlas anatomograms. Please use a more specific cell type term for annotation if possible, given the information available to you. subset: human_subset subset: location_grouping subset: mouse_subset synonym: "appendix dendritic cell" EXACT [] synonym: "dendritic cell of appendix vermiformis" EXACT [] synonym: "dendritic cell of vermiform appendix" EXACT [] is_a: CL:0000451 ! dendritic cell intersection_of: CL:0000451 ! dendritic cell intersection_of: BFO:0000050 UBERON:0001154 ! part of vermiform appendix relationship: BFO:0000050 UBERON:0001154 ! part of vermiform appendix property_value: terms:contributor https://orcid.org/0000-0002-2825-0621 [Term] id: CL:0009035 name: stromal cell of lamina propria of vermiform appendix def: "A stromal cell found in the lamina propria of the vermiform appendix." [http://orcid.org/0000-0003-3440-1876] subset: human_subset subset: location_grouping subset: mouse_subset synonym: "stromal cell of appendix lamina propria" EXACT [] synonym: "stromal cell of lamina propria of appendix vermiformis" EXACT [] is_a: CL:0009021 ! stromal cell of lamina propria of large intestine intersection_of: CL:0000499 ! stromal cell intersection_of: BFO:0000050 UBERON:0001154 ! part of vermiform appendix intersection_of: BFO:0000050 UBERON:0011189 ! part of lamina propria of large intestine relationship: BFO:0000050 UBERON:0001154 ! part of vermiform appendix property_value: terms:contributor https://orcid.org/0000-0002-2825-0621 [Term] id: CL:0009036 name: appendix macrophage def: "A macrophage located in the vermiform appendix." [http://orcid.org/0000-0003-3440-1876] comment: This is a general grouping term created for use in the EMBL-EBI Single Cell Expression Atlas anatomograms. Please use a more specific cell type term for annotation if possible, given the information available to you. subset: human_subset subset: location_grouping subset: mouse_subset synonym: "macrophage of appendix" EXACT [] synonym: "macrophage of appendix vermiformis" EXACT [] synonym: "macrophage of vermiform appendix" EXACT [] is_a: CL:0000235 ! macrophage intersection_of: CL:0000235 ! macrophage intersection_of: BFO:0000050 UBERON:0001154 ! part of vermiform appendix relationship: BFO:0000050 UBERON:0001154 ! part of vermiform appendix property_value: terms:contributor https://orcid.org/0000-0002-2825-0621 [Term] id: CL:0009037 name: lymph node mantle zone B cell def: "A B lymphocyte that resides in the mantle zone of the lymph node germinal center. These are generally IgM and IgD positive activated B cells that form a 'corona' around the germinal center and are part of the establishment of a secondary lymphatic follicule." [http://orcid.org/0000-0003-4183-8865/, https://www.arppress.org/v/vspfiles/assets/images/Chapter1T25LymphNodes.pdf, PMID:8011279] comment: This is a general grouping term created for use in the EMBL-EBI Single Cell Expression Atlas anatomograms. Please use a more specific cell type term for annotation if possible, given the information available to you. subset: human_subset subset: location_grouping subset: mouse_subset synonym: "mantle zone B cell" BROAD [] synonym: "mantle zone B cell of lymph node" EXACT [] is_a: CL:0000236 ! B cell intersection_of: CL:0000236 ! B cell intersection_of: BFO:0000050 UBERON:0010420 ! part of lymph node germinal center mantle zone relationship: BFO:0000050 UBERON:0010420 ! part of lymph node germinal center mantle zone property_value: terms:contributor https://orcid.org/0000-0002-2825-0621 [Term] id: CL:0009038 name: colon macrophage def: "A macrophage that is located in the colon." [http://orcid.org/0000-0003-3440-1876] comment: This is a general grouping term created for use in the EMBL-EBI Single Cell Expression Atlas anatomograms. Please use a more specific cell type term for annotation if possible, given the information available to you. subset: cellxgene_subset subset: human_subset subset: location_grouping subset: mouse_subset synonym: "macrophage of colon" EXACT [] is_a: CL:0000235 ! macrophage intersection_of: CL:0000235 ! macrophage intersection_of: BFO:0000050 UBERON:0001155 ! part of colon relationship: BFO:0000050 UBERON:0001155 ! part of colon property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0009038" xsd:string {name="colon macrophage on CELLxGENE CellGuide"} property_value: terms:contributor https://orcid.org/0000-0002-2825-0621 property_value: terms:description "Colon macrophages are a heterogeneous population of macrophages in the gastrointestinal tract. Intestinal macrophages represent the largest group of macrophages in the body and play a key role as sentinels for pathogen recognition and elimination. Because the gastrointestinal tract is continually exposed to a high antigenic load derived from microbes and food intake, macrophages in the intestines are crucial not only for the gut’s immune defense but also for maintaining gastrointestinal homeostasis, avoiding chronic inflammation despite constantly facing foreign antigens. The phenotypic profiles and cytokine production of intestinal macrophages therefore differ from conventional macrophages elsewhere in the body. \nColon macrophages orchestrate a wide variety of immune responses. They interact with the colon’s microflora thanks to their location in the mucosal layer, thus playing an important role in shaping gut immunity. By presenting antigens, they help to activate and steer an appropriate immune response either by triggering inflammation against harmful pathogens or by supporting tolerance for beneficial microbes. Therefore, disturbances in the colon macrophage population is thought to contribute to colon-related diseases such as inflammatory bowel disease and colon cancer. \nThese immune cells are versatile and multifunctional, not just limited to defensive actions. Colon macrophages interact with the enteric nervous system to regulate gut secretion and motility. They also play a crucial role in maintaining colon tissue health and integrity by contributing to tissue repair processes. This occurs either through phagocytosis of dead cells and remnants, or indirectly through the release of growth factor molecules, which stimulate cellular proliferation and differentiation necessary for tissue regeneration.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1016/j.immuni.2022.08.005", xref="DOI:10.1016/j.jcmgh.2021.08.021", xref="DOI:10.1038/s41575-019-0172-4", xref="DOI:10.1038/s41575-023-00769-0"} [Term] id: CL:0009039 name: colon goblet cell def: "A goblet cell that is located in the colon." [http://orcid.org/0000-0003-3440-1876] subset: cellxgene_subset subset: human_subset subset: location_grouping subset: mouse_subset synonym: "goblet cell of colon" EXACT [] is_a: CL:0011108 ! colon epithelial cell is_a: CL:1000320 ! large intestine goblet cell intersection_of: CL:0000160 ! goblet cell intersection_of: BFO:0000050 UBERON:0000397 ! part of colonic epithelium property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0009039" xsd:string {name="colon goblet cell on CELLxGENE CellGuide"} property_value: terms:contributor https://orcid.org/0000-0002-2825-0621 property_value: terms:description "Colon goblet cells are a subset of intestinal goblet cells that are localized in the epithelial lining of the colon. They are specialized secretory epithelial cells that are recognized by their characteristic ‘goblet’ or flask-like shape and typically have a distinctive appearance due to the accumulation of secretory vesicles in their cytoplasm.\nThe primary function of goblet cells is the secretion of mucus, which is an essential substance for the protection and successful functioning of the intestinal tract. In the colon, goblet cells continuously renew the inner mucus layer, which is attached and impervious to bacteria (the outer layer of the colon is unattached and is the habitat of commensal bacteria)\nThe mucus secreted by goblet cells is rich in glycoproteins known as mucins, especially MUC2, forming a complex web of molecules that comprises the foundational structure of the mucus layer. It traps and eliminates harmful bacteria, while selectively allowing beneficial microbiota to access the epithelial surface and aid in digestion and nutrient absorption. The mucus layer not only provides a provides a protective barrier against pathogen invasion, as well as mechanical damage, and the erosive effects of digestive enzymes, it also acts as a lubricant to facilitate the passage of food material.\nColon goblet cells are also involved in regulating the local immune response within the gut, maintaining the delicate balance between necessary immune reactions to harmful pathogens and tolerance to beneficial microbiota and dietary substances. Goblet cells can modulate immune responses by presenting antigens to dendritic cells, as well as through the production of immunomodulatory molecules that can alter the behavior of immune cells. When the inner mucus layer of the colon is defective, it might be a pathophysiological mechanism for colitis and infectious diseases.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1038/mi.2015.32", xref="DOI:10.1038/mi.2016.132", xref="DOI:10.1038/nrgastro.2013.35", xref="DOI:10.1038/s41385-018-0039-y", xref="DOI:10.1073/pnas.1006451107"} [Term] id: CL:0009040 name: stromal cell of lamina propria of colon def: "A stromal cell found in the lamina propria of the colon." [http://orcid.org/0000-0003-3440-1876] subset: human_subset subset: location_grouping subset: mouse_subset synonym: "stromal cell of colon lamina propria" EXACT [] is_a: CL:0009021 ! stromal cell of lamina propria of large intestine intersection_of: CL:0000499 ! stromal cell intersection_of: BFO:0000050 UBERON:0007177 ! part of lamina propria of mucosa of colon relationship: BFO:0000050 UBERON:0007177 ! part of lamina propria of mucosa of colon property_value: terms:contributor https://orcid.org/0000-0002-2825-0621 [Term] id: CL:0009041 name: tuft cell of colon def: "A tuft cell that is part of the colonic epithelium, primarily adapted for microbial sensing in the dense colonic microbiota. Unlike its small intestinal counterpart, it does not participate in parasite-driven tuft cell–ILC2 circuits. Instead, it detects bacterial metabolites via taste-signaling pathways (Strine and Craig, 2022). The colonic tuft cell plays a key role in epithelial repair, modulates inflammatory responses through IL-25 secretion, and contributes to intestinal homeostasis by balancing microbiome interactions (Sebastian et al., 2021)." [http://orcid.org/0000-0003-3440-1876, PMID:33079783, PMID:35271673] subset: cellxgene_subset subset: human_subset subset: location_grouping subset: mouse_subset synonym: "colon tuft cell" EXACT [] is_a: CL:0002203 ! tuft cell of large intestine is_a: CL:0011108 ! colon epithelial cell intersection_of: CL:0002204 ! tuft cell intersection_of: BFO:0000050 UBERON:0000397 ! part of colonic epithelium property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0009041" xsd:string {name="tuft cell of colon on CELLxGENE CellGuide"} property_value: terms:contributor https://orcid.org/0000-0002-2825-0621 property_value: terms:description "Tuft cells, also often referred to as brush cells or caveolated cells, are highly specialized sensory cells found in the colon, among other organs. They were named for their unique appearance under an electron microscope, which presents a distinctive ‘tuft-like’ morphology. They are characterized by apical microvilli, arranged in an irregular tuft that confers a dome-like shape. These cells comprise only a small fraction of the cells in the epithelial layer of the colon, making them among the least populous cell types in this region.\nTuft cells in the colon primarily function as chemosensory cells that can sense and respond to environmental changes. These cells can detect and respond to microbial metabolites, helping initiate immune responses against potential threats. \nRecent studies have revealed that tuft cells play a role in responding to intestinal parasitic infections. When a gastrointestinal parasite infects the colon, tuft cells are activated and release the cytokine IL-25. This action increases the production of tuft cells and triggers essential Th2 immune responses to expel the parasites. Also, the removal of tuft cells has been linked to increased susceptibility to these infections. However, overactivity of tuft cells has been associated with inflammatory bowel disease, highlighting the need for a delicate balance of tuft cell function to maintain colon homeostasis.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1152/ajpgi.00073.2017", xref="DOI:10.1371/journal.ppat.1010318", xref="DOI:10.3389/fimmu.2022.822867"} [Term] id: CL:0009042 name: enteroendocrine cell of colon def: "An enteroendocrine cell that is located in the colon." [http://orcid.org/0000-0003-3440-1876] subset: cellxgene_subset subset: human_subset subset: location_grouping subset: mouse_subset synonym: "colon enteroendocrine cell" EXACT [] is_a: CL:0011108 ! colon epithelial cell is_a: CL:1001516 ! intestinal enteroendocrine cell intersection_of: CL:0000164 ! enteroendocrine cell intersection_of: BFO:0000050 UBERON:0001155 ! part of colon property_value: terms:contributor https://orcid.org/0000-0002-2825-0621 [Term] id: CL:0009043 name: intestinal crypt stem cell of colon def: "An intestinal crypt stem cell that is located in the crypt of Lieberkuhn of colon." [http://orcid.org/0000-0003-3440-1876, PMID:10841502] subset: cellxgene_subset subset: human_subset subset: location_grouping subset: mouse_subset is_a: CL:0009016 ! intestinal crypt stem cell of large intestine intersection_of: CL:0002250 ! intestinal crypt stem cell intersection_of: BFO:0000050 UBERON:0013485 ! part of crypt of Lieberkuhn of colon relationship: BFO:0000050 UBERON:0013485 ! part of crypt of Lieberkuhn of colon property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0009043" xsd:string {name="intestinal crypt stem cell of colon on CELLxGENE CellGuide"} property_value: terms:contributor https://orcid.org/0000-0002-2825-0621 property_value: terms:description "Intestinal crypt stem cells of the colon, also known as colon crypt base columnar (CBC) cells, are highly specialized cells primarily responsible for the constant self-renewal of the colonic epithelium. These cells are found in the crypts of Lieberkühn - deeply invaginated sections of the colon's mucosal layer. \nThe prime function of intestinal crypt stem cells of the colon is to serve as the source of constant cell regeneration in the colon. Every few days, these stem cells divide and differentiate into the various other types of intestinal cells, such as enterocytes, goblet cells, and enteroendocrine cells. \nA constant renewal cycle is necessary due to the harsh environment of the colon where cells continuously encounter abrasive food matter and potential pathogens, leading to a high turnover rate. When the colon's mucosal layer suffers damage, a rapid response is triggered whereby colon crypt stem cells divide faster and are directed to injured sites to repair the epithelial layer. Dysregulation of these cells' function or proliferation can contribute to disorders such as colorectal cancer.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1016/j.cell.2013.07.004", xref="DOI:10.1038/s41575-018-0081-y", xref="DOI:10.1073/pnas.1607327113", xref="DOI:10.1111/j.1365-2184.2009.00642.x", xref="DOI:10.1186/s12943-019-0962-x"} [Term] id: CL:0009044 name: lymphocyte of small intestine lamina propria def: "A lymphocyte that resides in the lamina propria of the small intestine. Lamina propria leukocytes and intraepithelial lymphocytes are the effector compartments of the gut mucosal immune system. Lymphocytes circulate through gut associated lymphoid tissues until recruitment by intestinal antigens. They are involved in the gut immune response." [https://orcid.org/0000-0003-4183-8865, PMID:26551552] comment: This is a general grouping term created for use in the EMBL-EBI Single Cell Expression Atlas anatomograms. Please use a more specific cell type term for annotation if possible, given the information available to you. subset: human_subset subset: location_grouping subset: mouse_subset synonym: "gastrointestinal tract (lamina propria) lymphocyte of small intestine" EXACT [] synonym: "gastrointestinal tract small intestine (lamina propria) leukocyte" BROAD [] synonym: "lamina propria lymphocyte of small intestine" EXACT [] synonym: "small intestine lamina propria leukocyte" BROAD [] synonym: "small intestine lamina propria leukocyte (LPL)" BROAD [] synonym: "small intestine lamina propria lymphocyte" EXACT [] is_a: CL:0000542 ! lymphocyte intersection_of: CL:0000542 ! lymphocyte intersection_of: BFO:0000050 UBERON:0001238 ! part of lamina propria of small intestine relationship: BFO:0000050 UBERON:0001238 ! part of lamina propria of small intestine property_value: foaf:depiction http://purl.obolibrary.org/obo/cl/images/Small-intestine-cells.png {dc:license="http://creativecommons.org/licenses/by/4.0/", xref="doi:10.1186/s13619-020-00061-5", comment="Figure depicts a cross section of intestinal villi in the small intestine, including the crypts of Lieberkuhn (seen here as ‘crypt’), as well as the layer specific locations of cells that exist within the gastrointestinal tract. Layers depicted here include epithelium (rows of cells bordering villus), submucosa (white space below the epithelium containing networks of neurons and ganglia depicted in pink), muscularis mucosae (blue layer), muscularis propria (referred to here as muscle layer).\n\nISC: Intestinal Stem Cell \nTA: Transit Amplifying Cells"} property_value: terms:contributor https://orcid.org/0000-0002-2825-0621 [Term] id: CL:0009045 name: B cell of medullary sinus of lymph node def: "A B cell found in the lymph node medullary sinus." [http://orcid.org/0000-0003-4183-8865] comment: This is a general grouping term created for use in the EMBL-EBI Single Cell Expression Atlas anatomograms. Please use a more specific cell type term for annotation if possible, given the information available to you. subset: human_subset subset: location_grouping subset: mouse_subset is_a: CL:0000236 ! B cell intersection_of: CL:0000236 ! B cell intersection_of: BFO:0000050 UBERON:0009744 ! part of lymph node medullary sinus relationship: BFO:0000050 UBERON:0009744 ! part of lymph node medullary sinus property_value: terms:contributor https://orcid.org/0000-0002-2825-0621 [Term] id: CL:0009046 name: T cell of medullary sinus of lymph node def: "A T cell found in the lymph node medullary sinus." [http://orcid.org/0000-0003-4183-8865] comment: This is a general grouping term created for use in the EMBL-EBI Single Cell Expression Atlas anatomograms. Please use a more specific cell type term for annotation if possible, given the information available to you. subset: human_subset subset: location_grouping subset: mouse_subset is_a: CL:0000084 ! T cell intersection_of: CL:0000084 ! T cell intersection_of: BFO:0000050 UBERON:0009744 ! part of lymph node medullary sinus relationship: BFO:0000050 UBERON:0009744 ! part of lymph node medullary sinus property_value: terms:contributor https://orcid.org/0000-0002-2825-0621 [Term] id: CL:0009047 name: macrophage of medullary sinus of lymph node def: "A macrophage found in the medullary sinus of the lymph node." [http://orcid.org/0000-0003-4183-8865] comment: This is a general grouping term created for use in the EMBL-EBI Single Cell Expression Atlas anatomograms. Please use a more specific cell type term for annotation if possible, given the information available to you. subset: human_subset subset: location_grouping subset: mouse_subset synonym: "lymph node medullary sinus macrophage" EXACT [] synonym: "medullary sinus macrophage" BROAD [] is_a: CL:0000235 ! macrophage intersection_of: CL:0000235 ! macrophage intersection_of: BFO:0000050 UBERON:0009744 ! part of lymph node medullary sinus relationship: BFO:0000050 UBERON:0009744 ! part of lymph node medullary sinus property_value: terms:contributor https://orcid.org/0000-0002-2825-0621 [Term] id: CL:0009048 name: anorectum macrophage def: "A macrophage that is located in the anorectum." [http://orcid.org/0000-0003-3440-1876] comment: This is a general grouping term created for use in the EMBL-EBI Single Cell Expression Atlas anatomograms. Please use a more specific cell type term for annotation if possible, given the information available to you. subset: human_subset subset: location_grouping subset: mouse_subset synonym: "macrophage of anorectum" EXACT [] is_a: CL:0000235 ! macrophage intersection_of: CL:0000235 ! macrophage intersection_of: BFO:0000050 UBERON:8410050 ! part of anorectum relationship: BFO:0000050 UBERON:8410050 ! part of anorectum property_value: terms:contributor https://orcid.org/0000-0002-2825-0621 [Term] id: CL:0009049 name: smooth muscle cell of high endothelial venule of lymph node def: "A layer of smooth muscle cells that forms the outer layer of the high endothelial venule of lymph node and pumps to allow flow of lymph fluid carrying lymphocytes." [http://orcid.org/0000-0003-4183-8865, PMID:27881983] subset: human_subset subset: location_grouping subset: mouse_subset synonym: "high endothelial venule of lymph node smooth muscle cell" EXACT [] synonym: "high endothelial venule smooth muscle cell" BROAD [] is_a: CL:0008035 ! microcirculation associated smooth muscle cell is_a: CL:0019018 ! blood vessel smooth muscle cell intersection_of: CL:0000192 ! smooth muscle cell intersection_of: BFO:0000050 UBERON:8410038 ! part of high endothelial venule of lymph node relationship: BFO:0000050 UBERON:8410038 ! part of high endothelial venule of lymph node property_value: terms:contributor https://orcid.org/0000-0002-2825-0621 [Term] id: CL:0009050 name: B cell of anorectum def: "A B cell that is located in the anorectum." [http://orcid.org/0000-0003-3440-1876] comment: This is a general grouping term created for use in the EMBL-EBI Single Cell Expression Atlas anatomograms. Please use a more specific cell type term for annotation if possible, given the information available to you. subset: human_subset subset: location_grouping subset: mouse_subset is_a: CL:0000236 ! B cell intersection_of: CL:0000236 ! B cell intersection_of: BFO:0000050 UBERON:8410050 ! part of anorectum relationship: BFO:0000050 UBERON:8410050 ! part of anorectum property_value: terms:contributor https://orcid.org/0000-0002-2825-0621 [Term] id: CL:0009051 name: T cell of anorectum def: "A T cell that is located in the anorectum." [http://orcid.org/0000-0003-3440-1876] comment: This is a general grouping term created for use in the EMBL-EBI Single Cell Expression Atlas anatomograms. Please use a more specific cell type term for annotation if possible, given the information available to you. subset: human_subset subset: location_grouping subset: mouse_subset is_a: CL:0000084 ! T cell intersection_of: CL:0000084 ! T cell intersection_of: BFO:0000050 UBERON:8410050 ! part of anorectum relationship: BFO:0000050 UBERON:8410050 ! part of anorectum property_value: terms:contributor https://orcid.org/0000-0002-2825-0621 [Term] id: CL:0009052 name: smooth muscle cell of anorectum def: "A smooth muscle cell that is located in the anorectum." [http://orcid.org/0000-0003-3440-1876] subset: human_subset subset: location_grouping subset: mouse_subset synonym: "anorectum smooth muscle cell" EXACT [] is_a: CL:1000279 ! smooth muscle cell of large intestine intersection_of: CL:0000192 ! smooth muscle cell intersection_of: BFO:0000050 UBERON:8410050 ! part of anorectum relationship: BFO:0000050 UBERON:8410050 ! part of anorectum property_value: terms:contributor https://orcid.org/0000-0002-2825-0621 [Term] id: CL:0009053 name: stromal cell of anorectum lamina propria def: "A stromal cell found in the lamina propria of the anorectum." [http://orcid.org/0000-0003-3440-1876] subset: human_subset subset: location_grouping subset: mouse_subset is_a: CL:0009021 ! stromal cell of lamina propria of large intestine intersection_of: CL:0000499 ! stromal cell intersection_of: BFO:0000050 UBERON:0011189 ! part of lamina propria of large intestine intersection_of: BFO:0000050 UBERON:8410050 ! part of anorectum relationship: BFO:0000050 UBERON:8410050 ! part of anorectum property_value: terms:contributor https://orcid.org/0000-0002-2825-0621 [Term] id: CL:0009054 name: microfold cell of epithelium proper of anorectum def: "A microfold cell (M cell) that is part of the anorectum." [http://orcid.org/0000-0003-3440-1876] subset: human_subset subset: location_grouping subset: mouse_subset synonym: "M cell of anorectum" EXACT [] is_a: CL:1000360 ! microfold cell of epithelium proper of large intestine intersection_of: CL:0000682 ! M cell of gut intersection_of: BFO:0000050 UBERON:8410050 ! part of anorectum relationship: BFO:0000050 UBERON:8410050 ! part of anorectum property_value: terms:contributor https://orcid.org/0000-0002-2825-0621 [Term] id: CL:0009055 name: paneth cell of anorectum def: "A paneth cell that is located in the anorectum." [http://orcid.org/0000-0003-3440-1876] subset: human_subset subset: location_grouping subset: mouse_subset synonym: "anorectum paneth cell" EXACT [] is_a: CL:0000510 ! paneth cell is_a: CL:0002658 ! glandular cell of the large intestine intersection_of: CL:0000510 ! paneth cell intersection_of: BFO:0000050 UBERON:8410050 ! part of anorectum relationship: BFO:0000050 UBERON:8410050 ! part of anorectum property_value: terms:contributor https://orcid.org/0000-0002-2825-0621 [Term] id: CL:0009056 name: transit amplifying cell of anorectum def: "A transit amplifying cell that is located in the anorectum." [http://orcid.org/0000-0003-3440-1876] subset: human_subset subset: location_grouping subset: mouse_subset synonym: "anorectum transit amplifying cell" EXACT [] is_a: CL:0002253 ! epithelial cell of large intestine is_a: CL:4047017 ! transit amplifying cell of gut intersection_of: CL:4047017 ! transit amplifying cell of gut intersection_of: BFO:0000050 UBERON:8410050 ! part of anorectum relationship: BFO:0000050 UBERON:8410050 ! part of anorectum property_value: terms:contributor https://orcid.org/0000-0002-2825-0621 [Term] id: CL:0009057 name: anorectum goblet cell def: "A goblet cell that is located in the anorectum." [http://orcid.org/0000-0003-3440-1876] subset: human_subset subset: location_grouping subset: mouse_subset synonym: "goblet cell of anorectum" EXACT [] is_a: CL:1000320 ! large intestine goblet cell intersection_of: CL:1000320 ! large intestine goblet cell intersection_of: BFO:0000050 UBERON:8410050 ! part of anorectum relationship: BFO:0000050 UBERON:8410050 ! part of anorectum property_value: terms:contributor https://orcid.org/0000-0002-2825-0621 [Term] id: CL:0009058 name: enterocyte of anorectum def: "An enterocyte that is located in the anorectum." [http://orcid.org/0000-0003-3440-1876] subset: human_subset subset: location_grouping subset: mouse_subset synonym: "anorectum enterocyte" EXACT [] is_a: CL:0002071 ! enterocyte of epithelium of large intestine intersection_of: CL:0000584 ! enterocyte intersection_of: BFO:0000050 UBERON:8410050 ! part of anorectum relationship: BFO:0000050 UBERON:8410050 ! part of anorectum property_value: terms:contributor https://orcid.org/0000-0002-2825-0621 [Term] id: CL:0009059 name: plasma cell of medullary sinus of lymph node def: "A plasma cell that is located in the medullary sinus of the lymph node." [http://orcid.org/0000-0003-4183-8865] comment: This is a general grouping term created for use in the EMBL-EBI Single Cell Expression Atlas anatomograms. Please use a more specific cell type term for annotation if possible, given the information available to you. subset: human_subset subset: location_grouping subset: mouse_subset synonym: "medullary plasma cell" BROAD [] synonym: "medullary sinus plasma cell" BROAD [] synonym: "plasma cell of medullary sinus" BROAD [] is_a: CL:0000786 ! plasma cell intersection_of: CL:0000786 ! plasma cell intersection_of: BFO:0000050 UBERON:0009744 ! part of lymph node medullary sinus relationship: BFO:0000050 UBERON:0009744 ! part of lymph node medullary sinus property_value: terms:contributor https://orcid.org/0000-0002-2825-0621 [Term] id: CL:0009060 name: marginal zone B cell of lymph node def: "A mature B cell located in the marginal zone of the lymph node." [http://orcid.org/0000-0003-4183-8865, WikipediaVersioned:Marginal_zone_B-cell&oldid=1032071222] subset: human_subset subset: location_grouping subset: mouse_subset synonym: "lymph node marginal zone B cell" EXACT [] synonym: "marginal zone B cell" BROAD [] is_a: CL:0000785 ! mature B cell intersection_of: CL:0000785 ! mature B cell intersection_of: BFO:0000050 UBERON:8410065 ! part of lymph node follicle marginal zone relationship: BFO:0000050 UBERON:8410065 ! part of lymph node follicle marginal zone property_value: terms:contributor https://orcid.org/0000-0002-2825-0621 [Term] id: CL:0009061 name: intestinal crypt stem cell of anorectum def: "An intestinal crypt stem cell that is located in the anorectum." [http://orcid.org/0000-0003-3440-1876] subset: human_subset subset: location_grouping subset: mouse_subset synonym: "anorectum intestinal crypt stem cell" EXACT [] is_a: CL:0009016 ! intestinal crypt stem cell of large intestine intersection_of: CL:0009016 ! intestinal crypt stem cell of large intestine intersection_of: BFO:0000050 UBERON:8410050 ! part of anorectum relationship: BFO:0000050 UBERON:8410050 ! part of anorectum property_value: terms:contributor https://orcid.org/0000-0002-2825-0621 [Term] id: CL:0009062 name: germinal center T cell def: "A specialized type of CD4 positive T cell, the follicular helper T cell (TFH cell), that upregulates CXCR5 expression to enable its follicular localization. These specialised T cells reside in the germinal center of the lymph node." [http://orcid.org/0000-0003-4183-8865, PMID:21739669] subset: cellxgene_subset subset: human_subset subset: location_grouping subset: mouse_subset synonym: "lymph node germinal center T follicular helper cell" EXACT [] synonym: "T follicular helper cell of germinal center of lymph node" EXACT [] synonym: "T follicular helper cell of lymph node germinal center" EXACT [] is_a: CL:0002038 ! T follicular helper cell intersection_of: CL:0002038 ! T follicular helper cell intersection_of: BFO:0000050 UBERON:0009039 ! part of lymph node germinal center relationship: BFO:0000050 UBERON:0009039 ! part of lymph node germinal center property_value: terms:contributor https://orcid.org/0000-0002-2825-0621 [Term] id: CL:0009063 name: enteroendocrine cell of anorectum def: "An enteroendocrine cell that is located in the anorectum." [http://orcid.org/0000-0003-3440-1876] subset: human_subset subset: location_grouping subset: mouse_subset synonym: "anorectum enteroendocrine cell" EXACT [] is_a: CL:0002253 ! epithelial cell of large intestine is_a: CL:1001516 ! intestinal enteroendocrine cell intersection_of: CL:0000164 ! enteroendocrine cell intersection_of: BFO:0000050 UBERON:8410050 ! part of anorectum relationship: BFO:0000050 UBERON:8410050 ! part of anorectum property_value: terms:contributor https://orcid.org/0000-0002-2825-0621 [Term] id: CL:0009064 name: lymph node paracortex T cell def: "A T cell located in the lymph node paracortex, where macrophages and dendritic cells present antigenic peptides to these naïve T cells, stimulating them to become activated helper T cells or cytotoxic T lymphocytes." [http://orcid.org/0000-0003-4183-8865] subset: human_subset subset: location_grouping subset: mouse_subset synonym: "paracortex T cell" BROAD [] synonym: "paracortical T cell" BROAD [] synonym: "T cell of lymph node paracortex" EXACT [] is_a: CL:0000084 ! T cell intersection_of: CL:0000084 ! T cell intersection_of: BFO:0000050 UBERON:8410066 ! part of lymph node paracortex relationship: BFO:0000050 UBERON:8410066 ! part of lymph node paracortex property_value: terms:contributor https://orcid.org/0000-0002-2825-0621 [Term] id: CL:0009065 name: tuft cell of anorectum def: "An intestinal tuft cell that is located in the anorectum." [http://orcid.org/0000-0003-3440-1876] subset: human_subset subset: location_grouping subset: mouse_subset synonym: "anorectum tuft cell" EXACT [] is_a: CL:0002203 ! tuft cell of large intestine intersection_of: CL:0019032 ! intestinal tuft cell intersection_of: BFO:0000050 UBERON:8410050 ! part of anorectum relationship: BFO:0000050 UBERON:8410050 ! part of anorectum property_value: terms:contributor https://orcid.org/0000-0002-2825-0621 [Term] id: CL:0009066 name: stratified squamous epithelial cell of anal canal def: "A stratified squamous epithelial cell that is part of the anal canal." [http://orcid.org/0000-0003-3440-1876] comment: This is a general grouping term created for use in the EMBL-EBI Single Cell Expression Atlas anatomograms. Please use a more specific cell type term for annotation if possible, given the information available to you. subset: human_subset subset: location_grouping subset: mouse_subset synonym: "anal canal stratified squamous epithelial cell" EXACT [] is_a: CL:0000240 ! stratified squamous epithelial cell is_a: CL:0002253 ! epithelial cell of large intestine intersection_of: CL:0000240 ! stratified squamous epithelial cell intersection_of: BFO:0000050 UBERON:0015716 ! part of anal canal epithelium relationship: BFO:0000050 UBERON:0015716 ! part of anal canal epithelium property_value: terms:contributor https://orcid.org/0000-0002-2825-0621 [Term] id: CL:0009067 name: vacuolated fetal-type enterocyte def: "An enterocyte found in the small intestine of newborn mammals and characterized by the presence of an apical canalicular system (ACS) leading to production of large vacuoles, important for colostral macromolecule uptake. After birth, the vacuolated fetal-type enterocytes are replaced with enterocytes lacking an ACS." [http://orcid.org/0000-0002-7073-9172, PMID:17901585] subset: human_subset subset: mouse_subset synonym: "early enterocyte" RELATED [https://orcid.org/0000-0001-9610-7627, PMID:33290721] synonym: "immature enterocyte" RELATED [https://orcid.org/0000-0001-9610-7627, PMID:33290721] synonym: "vacuolated enterocyte" BROAD [] is_a: CL:0000584 ! enterocyte is_a: CL:0002254 ! epithelial cell of small intestine relationship: RO:0002162 NCBITaxon:40674 ! in taxon Mammalia property_value: terms:contributor https://orcid.org/0000-0002-2825-0621 [Term] id: CL:0009068 name: CD8aa(I) thymocyte def: "An unconventional T lymphocyte population within the thymic medulla that is potentially a thymic resident population." [PMID:32079746] subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset is_a: CL:0000893 ! thymocyte relationship: BFO:0000050 UBERON:0002124 ! part of medulla of thymus property_value: RO:0002175 NCBITaxon:9606 property_value: terms:contributor https://orcid.org/0000-0002-2825-0621 [Term] id: CL:0009069 name: CD8aa(II) thymocyte def: "An unconventional T lymphocyte population within the thymic medulla that expresses both alpha/beta and gamma/delta T cell signatures." [PMID:32079746] subset: human_reference_atlas subset: human_subset subset: mouse_subset is_a: CL:0000893 ! thymocyte relationship: BFO:0000050 UBERON:0002124 ! part of medulla of thymus property_value: RO:0002175 NCBITaxon:9606 property_value: terms:contributor https://orcid.org/0000-0002-2825-0621 [Term] id: CL:0009070 name: corticomedullary thymic epithelial cell def: "A thymic epithelial cell located at the corticomedullary junction." [PMID:32079746, PMID:33597545] subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset is_a: CL:0002293 ! epithelial cell of thymus relationship: BFO:0000050 UBERON:0003988 ! part of thymus corticomedullary boundary property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/2d-ftu/thymus-thymus-lobule/v1.3/assets/2d-ftu-thymus-thymus-lobule.png" xsd:string {terms:licence="http://creativecommons.org/licenses/by/4.0/", xref="doi:10.48539/HBM322.LZLG.752"} property_value: RO:0002175 NCBITaxon:9606 property_value: terms:contributor https://orcid.org/0000-0002-2825-0621 [Term] id: CL:0009071 name: medullary thymic epithelial cell type 1 def: "A thymic medullary epithelial cell considered to be a pre-AIRE mTEC population." [PMID:24084687, PMID:32079746, PMID:33597545] subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset is_a: CL:0002365 ! medullary thymic epithelial cell relationship: BFO:0000050 UBERON:0003846 ! part of thymus epithelium property_value: RO:0002175 NCBITaxon:9606 property_value: terms:contributor https://orcid.org/0000-0002-2825-0621 [Term] id: CL:0009072 name: medullary thymic epithelial cell type 2 def: "A thymic medullary epithelial cell that expresses AIRE or other canonical markers of mature mTECs like Fezf2." [PMID:17067941, PMID:24084687, PMID:32079746, PMID:33597545] subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset is_a: CL:0002365 ! medullary thymic epithelial cell relationship: BFO:0000050 UBERON:0003846 ! part of thymus epithelium property_value: RO:0002175 NCBITaxon:9606 property_value: terms:contributor https://orcid.org/0000-0002-2825-0621 [Term] id: CL:0009073 name: medullary thymic epithelial cell type 3 def: "A thymic medullary epithelial cell considered to be a post-AIRE cell. This group of AIRE-mTECs is heterogeneous and also includes mTECs within Hassall's Corpuscles." [PMID:16121185, PMID:17067941, PMID:20861360, PMID:24084687, PMID:32079746, PMID:33597545, PMID:33868260] subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "corneocyte-like medullary thymic epithelial cell" EXACT [PMID:33868260] synonym: "corneocyte-like mTECs" EXACT [PMID:33868260] synonym: "mTEC III" RELATED OMO:0003000 [PMID:33868260] synonym: "post-Aire cell" EXACT [PMID:33868260] is_a: CL:0002365 ! medullary thymic epithelial cell relationship: BFO:0000050 UBERON:0003846 ! part of thymus epithelium property_value: RO:0002175 NCBITaxon:9606 property_value: terms:contributor https://orcid.org/0000-0002-2825-0621 [Term] id: CL:0009074 name: medullary thymic epithelial cell type 4 def: "A thymic medullary epithelial cell that expresses typical tuft cell markers instead of classical mTEC or cTEC markers. This population has a bulbous-like structure." [PMID:30022164, PMID:32079746] subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "thymic tuft cell" BROAD [] is_a: CL:0002365 ! medullary thymic epithelial cell relationship: BFO:0000050 UBERON:0003846 ! part of thymus epithelium property_value: RO:0002175 NCBITaxon:9606 property_value: terms:contributor https://orcid.org/0000-0002-2825-0621 [Term] id: CL:0009075 name: myo-medullary thymic epithelial cell def: "A thymic medullary epithelial cell that expresses muscle-specific biomarkers." [PMID:32079746, PMID:33597545] subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset is_a: CL:0002365 ! medullary thymic epithelial cell relationship: BFO:0000050 UBERON:0003846 ! part of thymus epithelium property_value: RO:0002175 NCBITaxon:9606 property_value: terms:contributor https://orcid.org/0000-0002-2825-0621 [Term] id: CL:0009076 name: neuro-medullary thymic epithelial cell def: "A thymic medullary epithelial cell that expresses neuroendocrine biomarkers." [PMID:32079746, PMID:33597545] subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset is_a: CL:0002365 ! medullary thymic epithelial cell relationship: BFO:0000050 UBERON:0003846 ! part of thymus epithelium property_value: RO:0002175 NCBITaxon:9606 property_value: terms:contributor https://orcid.org/0000-0002-2825-0621 [Term] id: CL:0009077 name: subcapsular thymic epithelial cell def: "A thymic epithelial cell located within the subcapsular region of the thymus." [PMID:6209968] subset: human_reference_atlas subset: human_subset subset: mouse_subset is_a: CL:0002364 ! cortical thymic epithelial cell relationship: BFO:0000050 UBERON:0006936 ! part of thymus subcapsular epithelium property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/2d-ftu/thymus-thymus-lobule/v1.3/assets/2d-ftu-thymus-thymus-lobule.png" xsd:string {terms:licence="http://creativecommons.org/licenses/by/4.0/", xref="doi:10.48539/HBM322.LZLG.752"} property_value: RO:0002175 NCBITaxon:9606 property_value: terms:contributor https://orcid.org/0000-0002-2825-0621 [Term] id: CL:0009078 name: thymic fibroblast type 1 def: "A fibroblast located in the thymic capsule." [PMID:32079746] subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "thymic capsular fibroblast" EXACT [] is_a: CL:0000057 ! fibroblast is_a: CL:4030001 ! stromal cell of thymus relationship: BFO:0000050 UBERON:0002122 ! part of capsule of thymus property_value: RO:0002175 NCBITaxon:9606 property_value: terms:contributor https://orcid.org/0000-0002-2825-0621 [Term] id: CL:0009079 name: thymic fibroblast type 2 def: "A fibroblast located between thymic lobules." [PMID:32079746] subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "thymic interlobular fibroblast" EXACT [] is_a: CL:0000057 ! fibroblast is_a: CL:4030001 ! stromal cell of thymus relationship: BFO:0000050 UBERON:0004791 ! part of thymus trabecula property_value: RO:0002175 NCBITaxon:9606 property_value: terms:contributor https://orcid.org/0000-0002-2825-0621 [Term] id: CL:0009080 name: tuft cell of small intestine def: "A tuft cell located in the small intestine." [http://orcid.org/0000-0003-3440-1876, http://orcid.org/0000-0003-4183-8865] subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "brush cell of epithelium of small intestine" EXACT [] synonym: "brush cell of epithelium proper of small intestine" EXACT [] synonym: "brush cell of small intestine" EXACT [] synonym: "tuft cell of epithelium of small intestine" EXACT [] is_a: CL:0002254 ! epithelial cell of small intestine is_a: CL:0019032 ! intestinal tuft cell intersection_of: CL:0019032 ! intestinal tuft cell intersection_of: BFO:0000050 UBERON:0002108 ! part of small intestine relationship: BFO:0000050 UBERON:0001902 ! part of epithelium of small intestine property_value: foaf:depiction http://purl.obolibrary.org/obo/cl/images/Small-intestine-cells.png {terms:license="http://creativecommons.org/licenses/by/4.0/", xref="doi:10.1186/s13619-020-00061-5", comment="Figure depicts a cross section of intestinal villi in the small intestine, including the crypts of Lieberkuhn (seen here as ‘crypt’), as well as the layer specific locations of cells that exist within the gastrointestinal tract. Layers depicted here include epithelium (rows of cells bordering villus), submucosa (white space below the epithelium containing networks of neurons and ganglia depicted in pink), muscularis mucosae (blue layer), muscularis propria (referred to here as muscle layer).\n\nISC: Intestinal Stem Cell \nTA: Transit Amplifying Cells"} property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/2d-ftu/small-intestine-villus/v1.0/assets/2d-ftu-small-intestine-villus.png" xsd:string {terms:licence="http://creativecommons.org/licenses/by/4.0/", xref="doi:10.48539/HBM974.XQDB.889"} property_value: RO:0002175 NCBITaxon:9606 property_value: terms:contributor https://orcid.org/0000-0002-2825-0621 [Term] id: CL:0009081 name: specified double negative thymocyte (Homo sapiens) def: "The human equivalent of a DN2 thymocyte; typically contains two phases, in the latter of which these thymocytes begin the process of beta selection." [PMID:32304633] comment: There is growing evidence that molecular markers characterizing double negative thymocytes are different across species, especially in human versus mouse thymus. This term is restricted for use with human data. subset: human_reference_atlas subset: human_subset is_a: CL:0002489 ! double negative thymocyte relationship: RO:0002162 NCBITaxon:9606 ! in taxon Homo sapiens property_value: RO:0002175 NCBITaxon:9606 property_value: terms:contributor https://orcid.org/0000-0002-2825-0621 property_value: terms:date "2021-11-25T09:26:32Z" xsd:dateTime [Term] id: CL:0009082 name: committed double negative thymocyte (Homo sapiens) def: "The human equivalent of a DN3 thymocyte; these thymocytes finish the process of beta selection." [PMID:32304633] comment: There is growing evidence that molecular markers characterizing double negative thymocytes are different across species, especially in human versus mouse thymus. This term is restricted for use with human data. subset: human_reference_atlas subset: human_subset is_a: CL:0002489 ! double negative thymocyte relationship: RO:0002162 NCBITaxon:9606 ! in taxon Homo sapiens property_value: RO:0002175 NCBITaxon:9606 property_value: terms:contributor https://orcid.org/0000-0002-2825-0621 property_value: terms:date "2021-11-25T09:30:45Z" xsd:dateTime [Term] id: CL:0009083 name: rearranging double negative thymocyte (Homo sapiens) def: "The human equivalent of a DN4 thymocyte." [PMID:32304633] comment: There is growing evidence that molecular markers characterizing double negative thymocytes are different across species, especially in human versus mouse thymus. This term is restricted for use with human data. subset: human_reference_atlas subset: human_subset is_a: CL:0002489 ! double negative thymocyte relationship: RO:0002162 NCBITaxon:9606 ! in taxon Homo sapiens property_value: RO:0002175 NCBITaxon:9606 property_value: terms:contributor https://orcid.org/0000-0002-2825-0621 property_value: terms:date "2021-11-25T09:32:13Z" xsd:dateTime [Term] id: CL:0009084 name: glandular epithelial cell of endometrium def: "An epithelial cell that is part of an endometrium glandular epithelium." [https://orcid.org/0000-0003-3440-1876, https://orcid.org/0000-0003-4183-8865] subset: human_reference_atlas subset: human_subset subset: location_grouping subset: mouse_subset synonym: "endometrial glandular epithelial cell" EXACT [] synonym: "epithelial cell of endometrial gland" EXACT [] xref: EFO:0010710 is_a: CL:0002149 ! epithelial cell of uterus intersection_of: CL:0000066 ! epithelial cell intersection_of: BFO:0000050 UBERON:0012276 ! part of endometrium glandular epithelium relationship: BFO:0000050 UBERON:0012276 ! part of endometrium glandular epithelium property_value: RO:0002175 NCBITaxon:9606 property_value: terms:contributor https://orcid.org/0000-0002-2825-0621 property_value: terms:date "2021-11-30T16:13:30Z" xsd:dateTime [Term] id: CL:0009085 name: colony forming unit – Hill cell def: "An adult endothelial progenitor cell characterised in vivo by homing to ischemic sites and paracrine support of angiogenesis. They may form discrete colonies." [WikipediaVersioned:Endothelial_progenitor_cell&oldid=1069930016#Colony_forming_unit_–_Hill] subset: human_subset subset: mouse_subset synonym: "CFU-Hill" EXACT [] is_a: CL:0002619 ! adult endothelial progenitor cell property_value: terms:contributor https://orcid.org/0000-0002-2825-0621 property_value: terms:date "2022-02-18T09:55:33Z" xsd:dateTime [Term] id: CL:0009086 name: endothelial cell of respiratory system lymphatic vessel def: "An endothelial cell that is part of a respiratory system lymphatic vessel." [https://orcid.org/0000-0003-3440-1876, https://orcid.org/0000-0003-4183-8865] subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: location_grouping subset: mouse_subset xref: EFO:0010667 is_a: CL:0002138 ! endothelial cell of lymphatic vessel intersection_of: CL:0000115 ! endothelial cell intersection_of: BFO:0000050 UBERON:0003456 ! part of respiratory system lymphatic vessel relationship: BFO:0000050 UBERON:0003529 ! part of respiratory system lymphatic vessel endothelium property_value: RO:0002175 NCBITaxon:9606 property_value: terms:contributor https://orcid.org/0000-0002-2825-0621 property_value: terms:date "2021-12-03T14:00:44Z" xsd:dateTime [Term] id: CL:0009087 name: fused extravillous trophoblast def: "An extravillous trophoblast that is polynuclear." [https://orcid.org/0000-0003-3440-1876, https://orcid.org/0000-0003-4183-8865] subset: human_subset subset: mouse_subset synonym: "fused EVT" EXACT [] xref: EFO:0010712 is_a: CL:0008036 ! extravillous trophoblast property_value: terms:contributor https://orcid.org/0000-0002-2825-0621 property_value: terms:date "2021-12-03T14:37:32Z" xsd:dateTime [Term] id: CL:0009088 name: circulating angiogenic cell def: "An adult endothelial progenitor cell characterised in vivo by homing to ischemic sites and paracrine support of angiogenesis. These cells do not form colonies." [WikipediaVersioned:Endothelial_progenitor_cell&oldid=1069930016#Circulating_angiogenic_cell] subset: human_subset subset: mouse_subset is_a: CL:0002619 ! adult endothelial progenitor cell property_value: terms:contributor https://orcid.org/0000-0002-2825-0621 property_value: terms:date "2022-02-18T10:12:57Z" xsd:dateTime [Term] id: CL:0009089 name: lung pericyte def: "A pericyte cell that is part of a lung." [https://orcid.org/0000-0003-3440-1876, https://orcid.org/0000-0003-4183-8865] comment: The marker set HIGD1B, KCNK3 can identify the Human cell type lung pericyte in the lung with a confidence of 0.84 (NS-Forest FBeta value). {xref="https://doi.org/10.5281/zenodo.11165918"} subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: location_grouping subset: mouse_subset synonym: "lung pericyte cell" EXACT [] synonym: "pulmonary pericyte" EXACT [] xref: EFO:0010669 is_a: CL:0000669 ! pericyte intersection_of: CL:0000669 ! pericyte intersection_of: BFO:0000050 UBERON:0002048 ! part of lung relationship: BFO:0000050 UBERON:0002048 ! part of lung relationship: RO:0015004 CLM:1000047 ! has characterizing marker set NS forest marker set of lung pericyte (Human lung). property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/2d-ftu/lung-pulmonary-alveolus/v1.3/assets/2d-ftu-lung-pulmonary-alveolus.png" xsd:string {terms:licence="http://creativecommons.org/licenses/by/4.0/", xref="doi:10.48539/HBM558.BZLS.992"} property_value: RO:0002175 NCBITaxon:9606 property_value: terms:contributor https://orcid.org/0000-0002-2825-0621 property_value: terms:date "2021-12-03T17:13:33Z" xsd:dateTime [Term] id: CL:0009090 name: endothelial colony forming cell def: "An adult endothelial progenitor cell that is resident of adult vasculature and capable of differentiating to regenerate endothelial cell populations. Endothelial colony forming cells are characterised in vivo by clonal proliferative status, de novo vessel formation, homing to ischemic sites and paracrine support of angiogenesis. These cells are phenotypically similar to endothelial cells." [http://orcid.org/0000-0002-0819-0473, PMID:33419165, WikipediaVersioned:Endothelial_colony_forming_cell&oldid=1068242094] subset: human_subset subset: mouse_subset synonym: "ECFC" EXACT [] is_a: CL:0002619 ! adult endothelial progenitor cell relationship: BFO:0000050 UBERON:0004537 ! part of blood vasculature property_value: terms:contributor https://orcid.org/0000-0002-2825-0621 property_value: terms:date "2022-02-18T10:15:32Z" xsd:dateTime [Term] id: CL:0009091 name: Leydig stem cell def: "A stem cell found in the interstitial compartment of the neonatal testis; it is capable of self-renewal as well as differentiation into steroidogenic cells (adult Leydig cells). Intermediate stages of development include progenitor Leydig cells and immature Leydig cells." [http://orcid.org/0000-0002-0819-0473, PMID:21181888] subset: human_subset subset: mouse_subset synonym: "stem Leydig cell" EXACT [] is_a: CL:0000034 ! stem cell is_a: CL:4030031 ! interstitial cell relationship: BFO:0000050 UBERON:0005212 ! part of Leydig cell region of testis property_value: terms:contributor https://orcid.org/0000-0002-2825-0621 property_value: terms:date "2022-02-18T14:09:25Z" xsd:dateTime [Term] id: CL:0009092 name: endothelial cell of placenta def: "An endothelial cell that is part of a placenta." [https://orcid.org/0000-0003-3440-1876, https://orcid.org/0000-0003-4183-8865] subset: cellxgene_subset subset: human_subset subset: location_grouping subset: mouse_subset synonym: "placental endothelial cell" EXACT [] xref: EFO:0010708 is_a: CL:0000115 ! endothelial cell intersection_of: CL:0000115 ! endothelial cell intersection_of: BFO:0000050 UBERON:0001987 ! part of placenta relationship: BFO:0000050 UBERON:0001987 ! part of placenta property_value: terms:contributor https://orcid.org/0000-0002-2825-0621 property_value: terms:date "2021-12-13T13:53:01Z" xsd:dateTime [Term] id: CL:0009093 name: smooth muscle cell of placenta def: "A smooth muscle cell that is part of a placenta." [https://orcid.org/0000-0003-3440-1876, https://orcid.org/0000-0003-4183-8865] subset: human_subset subset: location_grouping subset: mouse_subset synonym: "placental smooth muscle cell" EXACT [] xref: EFO:0010709 is_a: CL:0000192 ! smooth muscle cell intersection_of: CL:0000192 ! smooth muscle cell intersection_of: BFO:0000050 UBERON:0001987 ! part of placenta relationship: BFO:0000050 UBERON:0001987 ! part of placenta property_value: terms:contributor https://orcid.org/0000-0002-2825-0621 property_value: terms:date "2021-12-13T13:56:42Z" xsd:dateTime [Term] id: CL:0009094 name: endothelial cell of hepatic portal vein def: "An endothelial cell that is part of a hepatic portal vein." [https://orcid.org/0000-0003-3440-1876, https://orcid.org/0000-0003-4183-8865, PMID:30348985] subset: human_subset subset: location_grouping subset: mouse_subset synonym: "portal endothelial cell" BROAD [] xref: EFO:0010704 is_a: CL:0002543 ! vein endothelial cell intersection_of: CL:0000115 ! endothelial cell intersection_of: BFO:0000050 UBERON:0001639 ! part of hepatic portal vein relationship: BFO:0000050 UBERON:0001639 ! part of hepatic portal vein property_value: terms:contributor https://orcid.org/0000-0002-2825-0621 property_value: terms:date "2021-12-13T14:01:05Z" xsd:dateTime [Term] id: CL:0009095 name: endothelial cell of uterus def: "An endothelial cell that is part of a uterus." [https://orcid.org/0000-0003-3440-1876, https://orcid.org/0000-0003-4183-8865] subset: cellxgene_subset subset: human_subset subset: location_grouping subset: mouse_subset synonym: "uterine endothelial cell" EXACT [] xref: EFO:0010711 is_a: CL:0000115 ! endothelial cell intersection_of: CL:0000115 ! endothelial cell intersection_of: BFO:0000050 UBERON:0000995 ! part of uterus relationship: BFO:0000050 UBERON:0000995 ! part of uterus property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0009095" xsd:string {name="endothelial cell of uterus on CELLxGENE CellGuide"} property_value: terms:contributor https://orcid.org/0000-0002-2825-0621 property_value: terms:date "2021-12-13T14:39:25Z" xsd:dateTime property_value: terms:description "The endothelial cell of the uterus is a specialized type of endothelial cell found in the inner lining of blood vessels, specifically those in the uterus. These cells play critical roles in maintaining uterine health, fertilization, and pregnancy processes. They form the interior surface of blood vessels, creating a barrier between the vessel lumen and surrounding tissue. This fluid environment, maintained by these endothelial cells, provides a platform for the material exchange between blood and tissues, thereby modulating blood coagulation, immune responses, and controlling vasodilation and vasoconstriction. \nFunctionally, the endothelial cells of the uterus are paramount in regulating the uterine blood flow, an important determinant of successful conception and pregnancy outcomes. They support the vascular changes during the reproductive cycle, particularly the spiral arteriolar development and function, essential in endometrial thickening, maturation, and eventual shedding during menstruation periods. The cells also contribute to angiogenesis, a process crucial during implantation and placenta development, whereby new blood vessels form from pre-existing vessels to supply the growing fetus with oxygen and nutrients. Uterine endothelial cells are also implicated in mediating immune responses within the uterus. Changes in these cells can influence various conditions such as reproductive disorders and complications including heavy menstrual bleeding, endometrial hyperplasia, fertility problems, and cancer.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1002/cphy.c190015", xref="DOI:10.1111/aji.12128", xref="DOI:10.1172/jci.insight.163422", xref="DOI:10.1530/REP-09-0147", xref="DOI:10.2174/1570161111311050010"} [Term] id: CL:0009096 name: esophagus non-keratinized squamous epithelial cell def: "Any cell that is part of the esophageal non-keratinized stratified squamous epithelium. In humans, the esophagus, which requires flexibility to accommodate swallowing of a bolus, is covered with a non-keratinized epithelium." [http://orcid.org/0000-0003-2034-601X, PMID:11694559] subset: human_subset subset: mouse_subset synonym: "esophageal non-keratinized squamous epithelial cell" EXACT [] synonym: "esophageal nonkeratinized squamous epithelial cell" EXACT [] synonym: "esophagus non-keratinizing squamous epithelial cell" EXACT [] synonym: "esophagus nonkeratinizing squamous epithelial cell" EXACT [] synonym: "non-keratinized squamous epithelial cell of esophagus" EXACT [] synonym: "non-keratinizing squamous epithelial cell of esophagus" EXACT [] synonym: "nonkeratinized squamous epithelial cell of esophagus" EXACT [] synonym: "nonkeratinizing squamous epithelial cell of esophagus" EXACT [] is_a: CL:0000238 ! non keratinizing barrier epithelial cell is_a: CL:0002252 ! epithelial cell of esophagus intersection_of: CL:0000238 ! non keratinizing barrier epithelial cell intersection_of: BFO:0000050 UBERON:0006920 ! part of esophagus squamous epithelium relationship: BFO:0000050 UBERON:0006920 ! part of esophagus squamous epithelium property_value: RO:0002175 NCBITaxon:9606 property_value: terms:contributor https://orcid.org/0000-0002-2825-0621 property_value: terms:date "2022-02-21T15:00:13Z" xsd:dateTime [Term] id: CL:0009097 name: embryonic skeletal muscle fiber def: "A skeletal muscle fiber found in an embryo. In mammalian embryos, skeletal muscle expresses myosin heavy chain-embryonic (MyHC-emb, encoded by the MYH3 gene), which regulates skeletal muscle development." [http://orcid.org/0000-0003-2034-601X, PMID:32094117, PMID:7196501] subset: human_subset subset: mouse_subset is_a: CL:0008002 ! skeletal muscle fiber intersection_of: CL:0008002 ! skeletal muscle fiber intersection_of: RO:0002491 UBERON:0000068 ! existence starts and ends during embryo stage relationship: RO:0002491 UBERON:0000068 ! existence starts and ends during embryo stage property_value: terms:contributor https://orcid.org/0000-0002-2825-0621 property_value: terms:date "2022-02-21T15:39:10Z" xsd:dateTime [Term] id: CL:0009098 name: fetal and neonatal skeletal muscle fiber def: "A skeletal muscle fiber found at the fetal and neonatal stages. In mammalian fetuses and neonates, skeletal muscle expresses myosin heavy chain-neonatal (MyHC-neo, encoded by the MYH8 gene). This expression disappears shortly after birth and is replaced by expression of adult heavy chain myosins." [http://orcid.org/0000-0003-2034-601X, PMID:26180627, PMID:7196501] subset: human_subset subset: mouse_subset is_a: CL:0008002 ! skeletal muscle fiber intersection_of: CL:0008002 ! skeletal muscle fiber intersection_of: RO:0002488 UBERON:0000092 ! existence starts during post-embryonic stage intersection_of: RO:0002492 UBERON:0007221 ! existence ends during neonate stage relationship: RO:0002488 UBERON:0000092 ! existence starts during post-embryonic stage relationship: RO:0002492 UBERON:0007221 ! existence ends during neonate stage property_value: terms:contributor https://orcid.org/0000-0002-2825-0621 property_value: terms:date "2022-02-21T15:43:16Z" xsd:dateTime [Term] id: CL:0009099 name: fibro/adipogenic progenitor cell def: "A progenitor cell that is a tissue-resident mesenchymal cell, important for skeletal muscle regeneration, and able to differentiate into both adipocytes or fibroblasts." [PMID:20081841, PMID:22045730, PMID:24605102] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "fibro/adipogenic progenitor" EXACT [] is_a: CL:0008019 ! mesenchymal cell is_a: CL:0011026 ! progenitor cell property_value: terms:contributor https://orcid.org/0000-0002-2825-0621 property_value: terms:date "2022-02-21T16:50:02Z" xsd:dateTime [Term] id: CL:0009100 name: hepatic portal fibroblast def: "A fibroblast located in the portal triad. Hepatic portal fibroblast are a non-parenchymal cell population located adjacent to bile duct epithelia in liver and are distinct from stellate cells. They differentiate into fibrogenic myofibroblasts during chronic injury states producing high levels of collagen." [https://orcid.org/0000-0001-7655-4833, PMID:20209607, PMID:24814904] subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "portal fibroblast" BROAD [] is_a: CL:0000057 ! fibroblast intersection_of: CL:0000057 ! fibroblast intersection_of: BFO:0000050 UBERON:0001279 ! part of portal triad relationship: BFO:0000050 UBERON:0001279 ! part of portal triad property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/2d-ftu/liver-liver-lobule/v1.3/assets/2d-ftu-liver-liver-lobule.png" xsd:string {terms:licence="http://creativecommons.org/licenses/by/4.0/", xref="doi:10.48539/HBM889.CJPK.447"} property_value: RO:0002175 NCBITaxon:9606 property_value: terms:contributor https://orcid.org/0000-0002-2825-0621 property_value: terms:date "2022-03-17T12:00:44Z" xsd:dateTime [Term] id: CL:0009101 name: fibroblastic reticular cell def: "A reticular cell involved in directing B cells and T cells to specific regions within a tissue." [] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "FRC" RELATED OMO:0003000 [PMID:35440118] is_a: CL:0000186 ! myofibroblast cell is_a: CL:0000432 ! reticular cell property_value: seeAlso "https://github.com/obophenotype/cell-ontology/issues/1472" xsd:string property_value: terms:contributor https://orcid.org/0000-0002-2825-0621 property_value: terms:date "2022-03-21T15:20:33Z" xsd:dateTime [Term] id: CL:0009102 name: lymph node fibroblastic reticular cell def: "A specialized, fibroblastic reticular cell of mesenchymal origin found in lymph nodes. In human, it expresses several markers common to myofibroblasts (desmin, vimentin, CD73, CD90, α-smooth muscle actin (αSMA)), and can be differentiated from endothelial cells by its lack of CD31 expression. These cells are critical for the overall organization and function of the lymph node. Lymph node fibroblastic reticular cells (FRCs) can be further classified based on their location, function, and unique marker expression." [https://orcid.org/0000-0001-7655-4833, PMID:21435450, PMID:22566825, PMID:25998961, PMID:28262465, PMID:29752062, PMID:34256989] subset: human_subset subset: mouse_subset synonym: "fibroblastic reticular cell" BROAD [] is_a: CL:0009101 ! fibroblastic reticular cell intersection_of: CL:0009101 ! fibroblastic reticular cell intersection_of: BFO:0000050 UBERON:0000029 ! part of lymph node relationship: BFO:0000050 UBERON:0000029 ! part of lymph node property_value: RO:0002175 NCBITaxon:9606 property_value: seeAlso "https://github.com/obophenotype/cell-ontology/issues/1472" xsd:string property_value: terms:contributor https://orcid.org/0000-0002-2825-0621 property_value: terms:date "2022-03-21T15:24:01Z" xsd:dateTime [Term] id: CL:0009103 name: lymph node marginal reticular cell def: "A fibroblastic reticular cell found in the lymph node subcapsular sinus." [https://orcid.org/0000-0001-7655-4833, PMID:21435450, PMID:22566825, PMID:25998961, PMID:28262465, PMID:29752062, PMID:34256989] subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "marginal reticular cell" BROAD [] is_a: CL:0009102 ! lymph node fibroblastic reticular cell relationship: RO:0001025 UBERON:0005463 ! located in subcapsular sinus of lymph node property_value: RO:0002175 NCBITaxon:9606 property_value: seeAlso "https://github.com/obophenotype/cell-ontology/issues/1472" xsd:string property_value: terms:contributor https://orcid.org/0000-0002-2825-0621 property_value: terms:date "2022-03-21T15:59:56Z" xsd:dateTime [Term] id: CL:0009104 name: B cell zone reticular cell def: "A fibroblastic reticular cell found in the lymph node germinal center dark zone (B cell zone)." [https://orcid.org/0000-0001-7655-4833, PMID:21435450, PMID:22566825, PMID:25998961, PMID:28262465, PMID:29752062, PMID:34256989] comment: B cell zone reticular cells share similarities with Ch25h-expresssing Ccl19lo T reticular cells found at the B cell follicle T zone interface of mouse lymph nodes. subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "lymph node germinal center dark zone fibroblastic reticular cell" EXACT [] synonym: "T-B boundary reticular cell" RELATED [] is_a: CL:0009102 ! lymph node fibroblastic reticular cell relationship: BFO:0000050 UBERON:8410053 ! part of lymph node germinal center dark zone property_value: RO:0002175 NCBITaxon:9606 property_value: seeAlso "https://github.com/obophenotype/cell-ontology/issues/1472" xsd:string property_value: terms:contributor https://orcid.org/0000-0002-2825-0621 property_value: terms:date "2022-03-21T16:55:46Z" xsd:dateTime [Term] id: CL:0009105 name: T cell zone reticular cell def: "A fibroblastic reticular cell found in the lymph node T cell domain." [https://orcid.org/0000-0001-7655-4833, PMID:21435450, PMID:22566825, PMID:25998961, PMID:28262465, PMID:29752062, PMID:34256989] subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "interfollicular reticular cell" RELATED [PMID:34256989] synonym: "lymph node T cell domain fibroblastic reticular cell" EXACT [] is_a: CL:0009102 ! lymph node fibroblastic reticular cell relationship: BFO:0000050 UBERON:0010417 ! part of lymph node T cell domain property_value: RO:0002175 NCBITaxon:9606 property_value: seeAlso "https://github.com/obophenotype/cell-ontology/issues/1472" xsd:string property_value: terms:contributor https://orcid.org/0000-0002-2825-0621 property_value: terms:date "2022-03-21T17:19:56Z" xsd:dateTime [Term] id: CL:0009106 name: medullary reticular cell def: "A specialized fibroblast found in the medulla of lymph node." [https://orcid.org/0000-0001-7655-4833, PMID:21435450, PMID:22566825, PMID:25998961, PMID:28262465, PMID:29752062, PMID:33981032, PMID:34256989] comment: Origin and phenotype of medullary reticular cells are less well understood in humans than in mice. subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "lymph node medullary reticular cell" EXACT [] synonym: "MedRC" RELATED OMO:0003000 [] synonym: "medullary reticular cell of lymph node" EXACT [] is_a: CL:0009102 ! lymph node fibroblastic reticular cell relationship: BFO:0000050 UBERON:0002007 ! part of medulla of lymph node property_value: RO:0002175 NCBITaxon:9606 property_value: seeAlso "https://github.com/obophenotype/cell-ontology/issues/1472" xsd:string property_value: terms:contributor https://orcid.org/0000-0002-2825-0621 property_value: terms:date "2022-03-22T09:03:15Z" xsd:dateTime [Term] id: CL:0009107 name: lymphatic endothelial cell of subcapsular sinus ceiling def: "A lymphatic endothelial cell located in the subcapsular sinus ceiling of a lymph node. In human, it's characterized by a unique marker expression (NT5e+ and Caveolin-1+)." [https://orcid.org/0000-0001-7655-4833, PMID:31402260, PMID:32426372] subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "lymphatic endothelial cell of subcapsular sinus ceiling of lymph node" EXACT [] is_a: CL:0009115 ! lymph node lymphatic vessel endothelial cell relationship: BFO:0000050 UBERON:8410071 ! part of subcapsular sinus ceiling property_value: RO:0002175 NCBITaxon:9606 property_value: terms:contributor https://orcid.org/0000-0002-2825-0621 property_value: terms:date "2022-03-22T10:30:28Z" xsd:dateTime [Term] id: CL:0009108 name: lymphatic endothelial cell of subcapsular sinus floor def: "A lymphatic endothelial cell located in the subcapsular sinus floor of a lymph node. In human, it's characterized by a unique marker expression (TNFRSF9+)." [https://orcid.org/0000-0001-7655-4833, PMID:31402260, PMID:32426372] subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "lymphatic endothelial cell of subcapsular sinus floor of lymph node" EXACT [] is_a: CL:0009115 ! lymph node lymphatic vessel endothelial cell relationship: BFO:0000050 UBERON:8410072 ! part of subcapsular sinus floor property_value: RO:0002175 NCBITaxon:9606 property_value: terms:contributor https://orcid.org/0000-0002-2825-0621 property_value: terms:date "2022-03-22T10:39:28Z" xsd:dateTime [Term] id: CL:0009109 name: lymphatic endothelial cell of trabecula def: "A lymphatic endothelial cell located in a lymph node trabecula." [https://orcid.org/0000-0001-7655-4833, PMID:31402260, PMID:32426372] subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "lymphatic endothelial cell of lymph node trabecula" EXACT [] synonym: "lymphatic endothelial cell of trabeculae" EXACT [] is_a: CL:0009115 ! lymph node lymphatic vessel endothelial cell relationship: BFO:0000050 UBERON:0002195 ! part of trabecula of lymph node property_value: RO:0002175 NCBITaxon:9606 property_value: terms:contributor https://orcid.org/0000-0002-2825-0621 property_value: terms:date "2022-03-23T15:08:44Z" xsd:dateTime [Term] id: CL:0009110 name: lymphatic endothelial cell of medulla ceiling def: "A lymphatic endothelial cell located in the ceiling part of a lymph node medulla." [https://orcid.org/0000-0001-7655-4833, PMID:31402260, PMID:32426372] subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "lymphatic endothelial cell of lymph node medulla ceiling" EXACT [] is_a: CL:0009115 ! lymph node lymphatic vessel endothelial cell relationship: BFO:0000050 UBERON:0002007 ! part of medulla of lymph node property_value: RO:0002175 NCBITaxon:9606 property_value: terms:contributor https://orcid.org/0000-0002-2825-0621 property_value: terms:date "2022-03-23T15:13:30Z" xsd:dateTime [Term] id: CL:0009111 name: centrocyte def: "A germinal center B cell found in a lymph node germinal center light zone." [https://orcid.org/0000-0001-7655-4833, PMID:17067937] subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "lymph node centrocyte" EXACT [] is_a: CL:0000844 ! germinal center B cell relationship: BFO:0000050 UBERON:8410052 ! part of lymph node germinal center light zone property_value: RO:0002175 NCBITaxon:9606 property_value: terms:contributor https://orcid.org/0000-0002-2825-0621 property_value: terms:date "2022-03-24T09:03:44Z" xsd:dateTime [Term] id: CL:0009112 name: centroblast def: "A germinal center B cell found in a lymph node germinal center dark zone." [https://orcid.org/0000-0001-7655-4833, PMID:17067937] subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "lymph node centroblast" EXACT [] is_a: CL:0000844 ! germinal center B cell relationship: BFO:0000050 UBERON:8410053 ! part of lymph node germinal center dark zone property_value: RO:0002175 NCBITaxon:9606 property_value: terms:contributor https://orcid.org/0000-0002-2825-0621 property_value: terms:date "2022-03-24T09:12:41Z" xsd:dateTime [Term] id: CL:0009113 name: T follicular regulatory cell def: "A regulatory T cell present in the B cell follicles and germinal centers of lymphoid tissues. In humans, it is CXCR5+." [https://orcid.org/0000-0001-7655-4833, PMID:15578096, PMID:26501424, PMID:29769249] subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "follicular regulatory T cell" EXACT [] is_a: CL:0000815 ! regulatory T cell relationship: BFO:0000050 UBERON:0001744 ! part of lymphoid tissue property_value: RO:0002175 NCBITaxon:9606 property_value: terms:contributor https://orcid.org/0000-0002-2825-0621 property_value: terms:date "2022-03-24T09:36:29Z" xsd:dateTime [Term] id: CL:0009114 name: monocytoid B cell def: "A B cell found in the perisinusoidal area of a lymph node. In humans, monocytoid B cells are a morphologically distinct B cell population\n(oval nuclei, abundant cytoplasm, monocyte-like appearance), share many similarities with marginal zone B cells including marker expression, and are increased in disease settings." [https://orcid.org/0000-0001-7655-4833, PMID:33324003] subset: human_reference_atlas subset: human_subset subset: mouse_subset is_a: CL:0000236 ! B cell relationship: BFO:0000050 UBERON:8410066 ! part of lymph node paracortex property_value: RO:0002175 NCBITaxon:9606 property_value: terms:contributor https://orcid.org/0000-0002-2825-0621 property_value: terms:date "2022-03-24T10:18:12Z" xsd:dateTime [Term] id: CL:0009115 name: lymph node lymphatic vessel endothelial cell def: "An endothelial cell located in a lymph node lymphatic vessel." [https://orcid.org/0000-0001-7655-4833] subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset is_a: CL:0002138 ! endothelial cell of lymphatic vessel intersection_of: CL:0000115 ! endothelial cell intersection_of: BFO:0000050 UBERON:0000029 ! part of lymph node intersection_of: BFO:0000050 UBERON:0001473 ! part of lymphatic vessel relationship: BFO:0000050 UBERON:0000029 ! part of lymph node property_value: RO:0002175 NCBITaxon:9606 property_value: seeAlso "https://github.com/obophenotype/cell-ontology/issues/1472" xsd:string property_value: terms:contributor https://orcid.org/0000-0002-2825-0621 [Term] id: CL:0009116 name: progenitor cell of mammary luminal epithelium def: "A progenitor cell with the potential to differentiate into luminal epithelial cells of mammary glands. In mouse, CD61 and c-kit were found to be coexpressed by the majority of, but not all, committed luminal progenitor cells." [https://orcid.org/0000-0003-4412-7970, PMID:19063729, PMID:20346151, PMID:21930782] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "luminal progenitor cell" BROAD [] synonym: "progenitor cell of luminal mammary epithelium" EXACT [] is_a: CL:0011026 ! progenitor cell relationship: BFO:0000050 UBERON:0001911 ! part of mammary gland property_value: terms:contributor https://orcid.org/0000-0002-2825-0621 [Term] id: CL:0010000 name: keratinized cell of hair follicle def: "A differentiating matrix keratinocyte that has initiated terminal differentiation and keratin synthesis. This cell undergoes a characteristic change while migrating upward from the hair follicle bulb, representing a committed progenitor cell destined to form the hair medulla, cortex and hair root sheath." [https://github.com/obophenotype/cell-ontology/issues/417, PMID:2478566, PMID:28445731, PMID:30420661] subset: human_subset subset: mouse_subset is_a: CL:2000092 ! hair follicular keratinocyte relationship: BFO:0000050 UBERON:0005932 ! part of bulb of hair follicle property_value: terms:date "2025-01-24T12:00:00Z" xsd:dateTime [Term] id: CL:0010001 name: stromal cell of bone marrow def: "A stromal cell that is part_of a bone marrow." [] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "bone marrow stromal cell" EXACT [] is_a: CL:0000499 ! stromal cell is_a: CL:0002092 ! bone marrow cell intersection_of: CL:0000499 ! stromal cell intersection_of: BFO:0000050 UBERON:0002371 ! part of bone marrow property_value: terms:contributor https://orcid.org/0000-0002-6601-2165 [Term] id: CL:0010002 name: epithelial cell of umbilical artery def: "An epithelial cell that is part_of a umbilical artery." [] subset: human_subset subset: mouse_subset synonym: "umbilical artery epithelial cell" EXACT [] is_a: CL:0000066 ! epithelial cell intersection_of: CL:0000066 ! epithelial cell intersection_of: BFO:0000050 UBERON:0001310 ! part of umbilical artery relationship: BFO:0000050 UBERON:0001310 ! part of umbilical artery property_value: terms:contributor https://orcid.org/0000-0002-6601-2165 [Term] id: CL:0010003 name: obsolete epithelial cell of alveolus of lung def: "OBSOLETE. An epithelial cell that is part_of a alveolus of lung." [] comment: This cell type is exactly the same as 'pulmonary alveolar epithelial cell'. synonym: "alveolus of lung epithelial cell" EXACT [] xref: MESH:D056809 property_value: IAO:0000233 https://github.com/obophenotype/cell-ontology/issues/2429 property_value: terms:contributor https://orcid.org/0000-0002-6601-2165 is_obsolete: true replaced_by: CL:0000322 [Term] id: CL:0010004 name: mononuclear cell of bone marrow def: "A mononuclear cell that is part_of a bone marrow." [] subset: human_subset subset: mouse_subset synonym: "bone marrow mononuclear cell" EXACT [] is_a: CL:0000842 ! mononuclear leukocyte is_a: CL:1001610 ! bone marrow hematopoietic cell intersection_of: CL:0000842 ! mononuclear leukocyte intersection_of: BFO:0000050 UBERON:0002371 ! part of bone marrow property_value: terms:contributor https://orcid.org/0000-0002-6601-2165 [Term] id: CL:0010005 name: atrioventricular bundle cell def: "A specialized cardiomyocyte that transmit signals from the AV node to the cardiac Purkinje fibers." [GOC:mtg_heart] subset: human_subset subset: mouse_subset synonym: "AV bundle cell" EXACT [] is_a: CL:0010007 ! His-Purkinje system cell intersection_of: CL:0000000 ! cell intersection_of: BFO:0000050 UBERON:0002353 ! part of bundle of His relationship: BFO:0000050 UBERON:0002353 ! part of bundle of His [Term] id: CL:0010006 name: cardiac blood vessel endothelial cell def: "Any blood vessel endothelial cell that is part of some heart." [FBC:Autogenerated] subset: cellxgene_subset subset: human_subset subset: mouse_subset is_a: CL:0000071 ! blood vessel endothelial cell is_a: CL:0010008 ! cardiac endothelial cell intersection_of: CL:0000071 ! blood vessel endothelial cell intersection_of: BFO:0000050 UBERON:0000948 ! part of heart property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0010006" xsd:string {name="cardiac blood vessel endothelial cell on CELLxGENE CellGuide"} property_value: terms:description "Cardiac blood vessel endothelial cells are a specialized type of endothelial cells that constitute the innermost layer, or endothelium, of blood vessels within the heart, namely the arteries, veins and capillaries. They function as a semi-permeable barrier, regulating the exchange of nutrients, ions, and small molecules between the blood and surrounding cardiac tissues. Additionally, they control the trafficking of white blood cells into the myocardium, playing a vital role in immune surveillance and response to pathogens.\nAn important feature of cardiac blood vessel endothelial cells is their contribution to vessel tone and blood pressure regulation. Endothelial cells release nitric oxide, a potent vasodilator, which helps to modulate blood vessel diameter as per the cardiac demands and maintain homeostasis. Moreover, these cells are active participants in the blood clotting process by expressing a variety of proteins and receptors that interact with platelets and plasma clotting factors.\nIn pathological conditions, the function of cardiac blood vessel endothelial cells can change dramatically, leading to various cardiovascular diseases. In response to injury or disease, these cells can proliferate and migrate contributing to vessel repair or aberrant remodelling, promote inflammation, and contribute to the formation of atherosclerotic plaques. Their ability to switch from a quiescent, anticoagulant phenotype to a more active, procoagulant state is a principal factor in thrombosis.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1016/j.ajpath.2020.10.001", xref="DOI:10.1038/s41569-022-00770-1", xref="DOI:10.1146/annurev.physiol.68.040104.124629", xref="DOI:10.1161/ATVBAHA.117.310549", xref="DOI:10.1161/circulationaha.105.602532"} [Term] id: CL:0010007 name: His-Purkinje system cell def: "Any cell that is part of some His-Purkinje system." [FBC:Autogenerated] subset: human_subset subset: mouse_subset is_a: CL:0002494 ! cardiocyte intersection_of: CL:0000000 ! cell intersection_of: BFO:0000050 UBERON:0004146 ! part of His-Purkinje system relationship: BFO:0000050 UBERON:0004146 ! part of His-Purkinje system [Term] id: CL:0010008 name: cardiac endothelial cell def: "Any endothelial cell that is part of some heart." [FBC:Autogenerated] subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset is_a: CL:0000115 ! endothelial cell is_a: CL:0002494 ! cardiocyte intersection_of: CL:0000115 ! endothelial cell intersection_of: BFO:0000050 UBERON:0000948 ! part of heart relationship: BFO:0000050 UBERON:0000948 ! part of heart property_value: RO:0002175 NCBITaxon:9606 property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0010008" xsd:string {name="cardiac endothelial cell on CELLxGENE CellGuide"} property_value: terms:description "Cardiac endothelial cells are a specialized subset of endothelial cells, the cell type responsible for forming the inner lining of cardiovascular structures such as the heart, and blood vessels. They are a pivotal component of the heart's microenvironment and play a key role in regulating blood pressure, maintaining cardiac homeostasis, in addition to cooperating with other cardiac cells like cardiomyocytes and fibroblasts in the orchestration of a coordinated heart function.\nCardiac endothelial cells contribute to the each stage of the heart's operation, whether during relaxation or contraction. Cardiac endothelial cells release nitric oxide, a potent vasodilator that regulates blood vessel dilation consequently controlling blood pressure and flow. They also produce a myriad of growth factors that aid in new blood vessel formation, known as angiogenesis, crucially needed for tissue repair and regeneration when the heart undergoes damage, as in cases of myocardial infarction.\nFurthermore, cardiac endothelial cells control the passage of nutrients, hormones, and gases between the bloodstream and the heart tissue, ensuring its complex metabolic demands are met adequately. They serve as a selective barrier, regulating the transit of cells and signaling molecules, thereby playing a pivotal role in inflammatory responses and immune cell trafficking. They also contribute to the maintenance of blood fluidity and clotting balance through a complex interplay of anti-thrombic and pro-thrombic factors.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1007/s00441-021-03471-2", xref="DOI:10.1530/VB-20-0006", xref="DOI:10.3389/fcvm.2018.00101", xref="DOI:10.3389/fphys.2018.00382", xref="DOI:10.3390/ijms20184411"} [Term] id: CL:0010009 name: camera-type eye photoreceptor cell def: "Any photoreceptor cell that is part of some camera-type eye." [FBC:Autogenerated] subset: human_subset subset: mouse_subset synonym: "camera type eye photoreceptor cell" EXACT [] is_a: BFO:0000002 is_a: CL:0000287 ! eye photoreceptor cell is_a: CL:0009004 ! retinal cell intersection_of: CL:0000210 ! photoreceptor cell intersection_of: BFO:0000050 UBERON:0000019 ! part of camera-type eye relationship: BFO:0000050 UBERON:0000966 {seeAlso="https://github.com/obophenotype/cell-ontology/issues/2245"} ! part of retina property_value: skos:prefLabel "camera-type eye photoreceptor cell" xsd:string [Term] id: CL:0010010 name: cerebellar stellate cell def: "A GABAergic interneuron that is located in the molecular layer of the cerebellum. This cell receives excitatory inputs primarily from parallel fibers and plays a crucial role in feed-forward inhibition by suppressing the activity of Purkinje cells and modulating the output of the cerebellar cortex. The stellate cell is part of the local circuitry that contributes to the fine-tuning of motor coordination and a regulator of cerebellar blood flow via neurovascular coupling." [PMID:31110133, PMID:5042759] subset: human_subset subset: mouse_subset synonym: "cerebellar SC" RELATED OMO:0003000 [PMID:31110133] is_a: CL:0000691 ! stellate interneuron is_a: CL:4042035 ! molecular layer interneuron intersection_of: CL:0000122 ! stellate neuron intersection_of: RO:0002100 UBERON:0002974 ! has soma location molecular layer of cerebellar cortex property_value: foaf:depiction Candelabrum:cell.jpg {dc:license="https://creativecommons.org/licenses/by-nc-nd/4.0/", xref="doi:10.3389/fnins.2020.00293"} property_value: foaf:depiction http://purl.obolibrary.org/obo/cl/images/CB_circuits_PMID3650468_f2.png {dc:license="https://creativecommons.org/licenses/by-nc-nd/4.0/", xref="doi:10.1016/j.cnp.2022.11.002"} [Term] id: CL:0010011 name: cerebral cortex GABAergic interneuron def: "A GABAergic interneuron whose soma is located in the cerebral cortex." [GOC:dos] subset: cellxgene_subset subset: human_subset subset: mouse_subset is_a: CL:0008031 ! cortical interneuron is_a: CL:0011005 ! GABAergic interneuron intersection_of: CL:0011005 ! GABAergic interneuron intersection_of: RO:0002100 UBERON:0000956 ! has soma location cerebral cortex property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0010011" xsd:string {name="cerebral cortex GABAergic interneuron on CELLxGENE CellGuide"} property_value: terms:description "The cerebral cortex GABAergic interneuron is a type of neuron found primarily in the brain's cerebral cortex. These neurons are distinguished by their primary inhibitory neurotransmitter, gamma-aminobutyric acid (GABA) which plays a crucial role in managing the excitability of neurons. Interneurons, in general, function as primary regulators of data flow in the nervous system. They manage the communication between sensory and motor neurons, influencing our responses to environmental stimuli.\nThe cerebral cortex GABAergic interneurons are particularly essential for the proper functioning of cerebral cortical networks. These neurons generate diverse inhibition patterns, creating a balance between excitation and inhibition in neuronal networks. This balance is fundamental in ensuring normal cortical processes such as sensory perception, memory, and cognitive functions. The diverse range of GABAergic interneurons contributes to generating distinct cortical rhythms which are linked with specific behavioral states, mental health, and neurological diseases.\nAlterations or disruptions in the function of cerebral cortex GABAergic interneurons can have serious implications, and have been associated with various neurological and psychiatric conditions such as epilepsy, schizophrenia, and autism. The heterogeneity of cerebral cortex GABAergic interneurons, in terms of their morphology, connectivity, and physiology, contribute greatly to the functional diversity of the cerebral cortex.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1016/j.conb.2023.102703", xref="DOI:10.1016/j.neuron.2013.01.011", xref="DOI:10.1016/j.neuron.2018.10.009", xref="DOI:10.1038/nrn2402", xref="DOI:10.1038/nrn3155"} [Term] id: CL:0010012 name: cerebral cortex neuron alt_id: CL:0002609 def: "A CNS neuron of the cerebral cortex." [GOC:tfm] subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "cortical neuron" EXACT [] synonym: "neuron of cerebral cortex" EXACT [] xref: BTO:0004102 xref: FMA:84104 is_a: CL:0012001 ! neuron of the forebrain intersection_of: CL:0000540 ! neuron intersection_of: RO:0002100 UBERON:0000956 ! has soma location cerebral cortex relationship: RO:0002100 UBERON:0000956 ! has soma location cerebral cortex property_value: RO:0002175 NCBITaxon:9606 property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0010012" xsd:string {name="cerebral cortex neuron on CELLxGENE CellGuide"} property_value: seeAlso "https://github.com/obophenotype/cell-ontology/issues/1359" xsd:string property_value: skos:prefLabel "cerebral cortex neuron" xsd:string property_value: terms:contributor https://orcid.org/0000-0001-7258-9596 property_value: terms:description "A cerebral cortex neuron, also known as a cortical neuron, is a unique type of cell found in the cerebral cortex, which is the outer covering of the brain. This region is critical to cognitive functions, sensory input processes, memory formation, attention, and consciousness. These neurons are one of the most abundant cell type in the cortex and allow for the intricate capabilities of the human brain due to their diverse characteristics and complex connectivity.\nThe primary function of cortical neurons is to manage and interpret the sensory input being received by the brain, generating suitable motor output responses. They play a critical role in processing information and communication within the brain. These neurons are involved in the exchange of direct synaptic communication with thousands of other neurons. Due to the wide extent of their dendritic and axonal arbors, these neurons present a broad receptive field for incoming information and an expansive projecting field to convey integrated information.\nCortical neurons further define the functional structure of the cerebral cortex by their type and connection. They can be broken down into two categories: excitatory projection neurons and inhibitory interneurons. The excitatory projection neurons are the principal neurons of the cerebral cortex and utilize glutamate as a neurotransmitter. They form the connections between the cerebral cortex and other brain regions, hence their tag as \"projection\" neurons. Conversely, inhibitory interneurons are local to the cerebral cortex and use gamma-aminobutyric acid (GABA) as a neurotransmitter, serving to regulate the activity of the projection neurons. Through these intricate interconnections, cerebral cortex neurons play a significant role in the higher cognitive functions of the human brain.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1016/j.neuron.2011.01.015", xref="DOI:10.1016/j.tics.2022.08.012", xref="DOI:10.1038/nrn2151", xref="DOI:10.1038/s41586-021-04230-7", xref="DOI:10.1186/s13064-018-0104-y"} [Term] id: CL:0010013 name: type I pinealocyte subset: human_subset subset: mouse_subset synonym: "light pinealocyte" EXACT [] is_a: CL:0000652 ! pinealocyte [Term] id: CL:0010014 name: type II pinealocyte subset: human_subset subset: mouse_subset synonym: "dark pinealocyte" EXACT [] is_a: CL:0000652 ! pinealocyte [Term] id: CL:0010015 name: coronet cell def: "A highly specialized cell type exclusive to and forming neuroepithelium of the Saccus vasculosus, covering the caudal diverticulum of the infundibular recess." [GOC:mr, PMID:17595538] comment: Editor note: remember to link to Saccus vasculosus in next uberon release subset: human_subset subset: mouse_subset is_a: CL:0000066 ! epithelial cell [Term] id: CL:0010016 name: collar cell def: "A cell with a flagellum surrounded by a collar of microvilli. The motion of the flagellum draws water past the microvilli, serving either a feeding or sensory function. Collar cells are found in multiple animals, including sponges, echinoderms, and cnidarians. They are also found outside animals in the choanoflagellates. Although collar cells are superficially similar, their cytoskeletal structure and functional biology are different in different groups of organisms." [PMID:25840473] subset: human_subset subset: mouse_subset is_a: CL:0000064 ! ciliated cell [Term] id: CL:0010017 name: zygote def: "A zygote in a plant or an animal." [] subset: human_subset subset: mouse_subset xref: MESH:D015053 is_a: CL:0000000 ! cell property_value: seeAlso https://github.com/obophenotype/cell-ontology/issues/786 property_value: skos:prefLabel "zygote" xsd:string [Term] id: CL:0010020 name: cardiac glial cell def: "Any glial cell that is part of some heart." [FBC:Autogenerated] subset: human_subset subset: mouse_subset is_a: CL:0000125 ! glial cell is_a: CL:0002494 ! cardiocyte intersection_of: CL:0000125 ! glial cell intersection_of: BFO:0000050 UBERON:0000948 ! part of heart relationship: BFO:0000050 UBERON:0000948 ! part of heart [Term] id: CL:0010021 name: cardiac myoblast def: "Any myoblast that develops into some cardiac muscle cell." [FBC:Autogenerated] subset: human_subset subset: mouse_subset xref: MESH:D032386 is_a: CL:0000056 ! myoblast intersection_of: CL:0000056 ! myoblast intersection_of: RO:0002203 CL:0000746 ! develops into cardiac muscle cell relationship: RO:0002203 CL:0000746 ! develops into cardiac muscle cell [Term] id: CL:0010022 name: cardiac neuron def: "A neuron that has its soma in the heart." [PMID:12486170, PMID:29265764] comment: This term is used in 3 GO terms that were created as part of the heart development focus project. subset: cellxgene_subset subset: human_subset subset: mouse_subset is_a: BFO:0000002 is_a: CL:2000032 ! peripheral nervous system neuron intersection_of: CL:2000032 ! peripheral nervous system neuron intersection_of: RO:0002100 UBERON:0000948 ! has soma location heart relationship: RO:0002100 UBERON:0000948 ! has soma location heart property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0010022" xsd:string {name="cardiac neuron on CELLxGENE CellGuide"} property_value: seeAlso "https://github.com/obophenotype/cell-ontology/pull/1488" xsd:string property_value: terms:description "Cardiac neurons are a specialized type of neuron found within the heart tissue. They are the primary constituents of the intrinsic cardiac nervous system, also known as the cardiac plexus or intrinsic cardiac ganglia, which is responsible for the regulation of the heart's rhythmic contractions and overall functioning. This group of neurons is integral to the autonomic control of the heart and plays a crucial role in modulating cardiac activity, thereby playing an essential role in maintaining cardiovascular homeostasis.\nThese neurons are responsible for both the sympathetic and parasympathetic regulation of the heart’s function. In terms of sympathetic control, cardiac neurons respond to the release of norepinephrine, which increases heart rate, strength of contractions, and blood pressure. Conversely, with regards to parasympathetic control, these neurons respond to the neurotransmitter acetylcholine, which decreases heart rate, blood pressure, and the strength of contractions. Thus, the balance between these sympathetic and parasympathetic inputs regulated by cardiac neurons is essential for normal heart function.\nCardiac neurons also partake in the transmission of pain signals during conditions such as myocardial ischemia, contributing to the symptomatology of ischemic heart disease. Additionally, abnormal function or pathological alterations in these neurons could lead to various cardiac dysfunctions, including arrhythmias and heart failure.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1002/cphy.c150046", xref="DOI:10.1016/j.autneu.2016.08.006", xref="DOI:10.1152/ajpregu.00183.2004", xref="DOI:10.1161/01.RES.84.8.921", xref="DOI:10.3390/jcdd7040054"} [Term] id: CL:0011000 name: dorsal horn interneuron def: "A CNS interneuron located in the dorsal horn of the spinal cord." [GOC:nv] subset: human_subset subset: mouse_subset synonym: "dorsal spinal cord interneuron" RELATED [] is_a: CL:0002611 ! neuron of the dorsal spinal cord is_a: CL:0005000 {is_inferred="true"} ! spinal cord interneuron intersection_of: CL:0000099 ! interneuron intersection_of: RO:0002100 UBERON:0002256 ! has soma location dorsal horn of spinal cord [Term] id: CL:0011001 name: spinal cord motor neuron def: "A motor neuron that passes from the spinal cord toward or to a muscle and conducts an impulse that causes movement." [GOC:nv] subset: cellxgene_subset subset: human_subset subset: mouse_subset is_a: CL:0000100 {is_inferred="true"} ! motor neuron is_a: CL:2000029 ! central nervous system neuron intersection_of: CL:0000100 ! motor neuron intersection_of: RO:0002100 UBERON:0002240 ! has soma location spinal cord relationship: RO:0002100 UBERON:0002240 ! has soma location spinal cord [Term] id: CL:0011002 name: lateral motor column neuron def: "A motor neuron that is generated only on limb levels and send axons into the limb mesenchyme." [GOC:nv] comment: Need to MIREOT in 'spinal cord lateral column' from Uberon subset: human_subset subset: mouse_subset is_a: CL:0011001 ! spinal cord motor neuron [Term] id: CL:0011003 name: magnocellular neurosecretory cell def: "A neurosecretory neuron residing mainly in the hypothalamic supraoptic and paraventricular nuclei and in a number of smaller accessory cell groups between these two nuclei, that is capable of secreting the hormones oxytocin or vasopressin, and sometimes both, into the systemic circulation." [GOC:nv, MP:0009467, PMID:10711808] subset: human_subset subset: mouse_subset synonym: "magnocellular neuron" EXACT [] xref: ILX:0107463 is_a: CL:0000165 ! neuroendocrine cell is_a: CL:0012001 ! neuron of the forebrain relationship: RO:0002100 UBERON:0001898 ! has soma location hypothalamus property_value: terms:contributor https://orcid.org/0000-0001-7258-9596 [Term] id: CL:0011004 name: lens fiber cell def: "A vetebrate lens cell that is any of the elongated, tightly packed cells that make up the bulk of the mature lens in a camera-type eye." [GO:0070307, GOC:nv] subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "lens fibre cell" EXACT [] xref: ZFA:0009401 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0002222 ! vertebrate lens cell property_value: RO:0002175 NCBITaxon:9606 property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0011004" xsd:string {name="lens fiber cell on CELLxGENE CellGuide"} property_value: terms:description "Lens fiber cells are specialized, elongated cells located in the ocular lens, an important part of the eye responsible for focusing light onto the retina to create clear defined images. These cells are unique among body cells, as they are transparent and filled with a clear protein called crystallin to facilitate the passage of light.\nThe entire life cycle of a lens fiber cell includes differentiation from lens epithelial cells, which are the progenitor cells lying at the anterior surface of the lens. In response to various signals, these cells elongate and migrate towards the posterior pole, while simultaneously undergoing a process of denucleation and degradation of cellular organelles. This unique process ensures that the cells do not scatter light, which is critical for the transparency of the lens. After reaching full maturity, lens fiber cells form tightly packed layers, known as laminae, to make up the distinctive architecture of the ocular lens. \nLens fiber cells play pivotal roles in vision. Their primary function is to transmit and focus the light that enters the eye onto the retina, providing the sharpness and clarity necessary for vision. The precise alignment and organization of these cells allow for optimal light transmittance and minimizes scattering, thereby maintaining the transparency of the lens. As such, disruptions or abnormalities in lens fiber cells can lead to serious vision impairment, including conditions like cataracts, a common condition characterized by the opacification of the lens.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1016/j.exer.2016.03.016", xref="DOI:10.1016/j.pbiomolbio.2003.11.012", xref="DOI:10.1098/rstb.2010.0300", xref="DOI:10.1242/dev.107953", xref="https://www.sciencedirect.com/topics/immunology-and-microbiology/lens-fiber"} [Term] id: CL:0011005 name: GABAergic interneuron def: "An interneuron that uses GABA as a vesicular neurotransmitter. These interneurons are inhibitory" [GOC:CellBLAST, GOC:nv, PMID:29724907] comment: The formal and textual definitions of this term will need to be altered if evidence for non-inhibitory GABA-ergic neurons emerges. subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "GABAergic inhibitory interneuron" EXACT [] is_a: CL:0000498 ! inhibitory interneuron is_a: CL:0000617 ! GABAergic neuron intersection_of: CL:0000099 ! interneuron intersection_of: RO:0002215 GO:0061534 ! capable of gamma-aminobutyric acid secretion, neurotransmission property_value: RO:0002175 NCBITaxon:9606 property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0011005" xsd:string {name="GABAergic interneuron on CELLxGENE CellGuide"} property_value: skos:prefLabel "GABAergic interneuron" xsd:string property_value: terms:description "GABAergic interneurons, a major subtype of neurons, are characterized by the secretion of gamma-aminobutyric acid (GABA) – the primary inhibitory neurotransmitter in the central nervous system (CNS) of mammals. These cells play a crucial role in balancing the excitatory and inhibitory neurotransmission within neural networks. GABAergic neurons are particularly important for maintaining homeostasis within the brain, and any imbalance in GABAergic neurotransmission is often associated with neurological disorders such as epilepsy, schizophrenia, and mood disorders, highlighting their significance in the nervous system.\nThe primary function of GABAergic interneurons is to inhibit neural transmission or modulate the degree of activation of other neurons. They achieve this task by releasing GABA neurotransmitter, which binds to GABA receptors on other cells, resulting in a decrease of neuronal excitability. They form extensive circuits and are intricately involved in various neural processes including learning and memory, sensory perception, and motor control among others. Additionally, subsets of GABAergic interneurons serve as pacemakers in various brain rhythms thus contributing to cognitive processes such as attention and sensory perception.\nGABAergic interneurons are not a homogenous group, they vary in terms of morphology, distribution, and function in the brain. For example, interneurons in the hippocampus regulate the transmission of information by inhibiting the flow of excitatory signals as part of a feedback loop. Other types, found predominantly in the cerebral cortex (like basket cells), exert control over a larger network of cells. Thus, despite being inhibitory in nature, their impact on neuronal circuitry broadens the diversity of information flow within the brain, hence potentiating information processing and ensuring proper nervous system function.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1016/S0074-7696(02)13011-7", xref="DOI:10.1016/S0893-133X(01)00225-1", xref="DOI:10.1016/j.neuron.2013.01.011", xref="DOI:10.1038/s41583-019-0195-4", xref="DOI:10.1152/physrev.00007.2017"} [Term] id: CL:0011006 name: Lugaro cell def: "A cerebellar interneuron characterized by a spindle-shaped or triangular soma, parasagittally oriented and located at the border between the granular layer and the Purkinje cell layer. The Lugaro cell extends dendrites predominantly in the parasagittal plane, forming synaptic interactions with basket, stellate, and Golgi cells. Its axonal projections extend upward into the molecular layer, where they form a parasagittal plexus and emit long transverse collaterals that run parallel to the long axis of the cerebellar folia. The Lugaro cell is capable of co-releasing GABA and glycine, as evidenced by the expression of glutamate decarboxylase (GAD65/67) and the glycine transporter GlyT2." [GOC:nv, PMID:18677503, PMID:2273099] subset: human_subset subset: mouse_subset synonym: "globular cell" RELATED [PMID:34194302] is_a: CL:0008059 ! GABA-Gly neuron is_a: CL:4023057 ! cerebellar inhibitory GABAergic interneuron relationship: RO:0002100 UBERON:0002956 ! has soma location granular layer of cerebellar cortex property_value: foaf:depiction Candelabrum:cell.jpg {dc:license="https://creativecommons.org/licenses/by-nc-nd/4.0/", xref="doi:10.3389/fnins.2020.00293"} property_value: foaf:depiction http://purl.obolibrary.org/obo/cl/images/CB_circuits_PMID3650468_f2.png {dc:license="https://creativecommons.org/licenses/by-nc-nd/4.0/", xref="doi:10.1016/j.cnp.2022.11.002"} [Term] id: CL:0011007 name: paraxial cell def: "A cell in the area of mesoderm in the neurulating embryo that flanks and forms simultaneously with the neural tube. The cells of this region give rise to somites." [GOC:NV, PMID:11687492] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "paraxial mesoderm cell" EXACT [] synonym: "presomitic mesoderm cell" NARROW [] synonym: "somitic mesoderm cell" EXACT [] is_a: CL:0000222 ! mesodermal cell intersection_of: CL:0000222 ! mesodermal cell intersection_of: BFO:0000050 UBERON:0003059 ! part of presomitic mesoderm relationship: BFO:0000050 UBERON:0003059 ! part of presomitic mesoderm [Term] id: CL:0011008 name: embryonic hemocyte def: "A hemocyte derived from the embryonic head mesoderm, which enters the hemolymph as a circulating cell." [GOC:NV, PMID:17967061] is_a: CL:0000387 ! hemocyte (sensu Arthropoda) [Term] id: CL:0011009 name: embryonic plasmatocyte def: "A plasmatocyte derived from the embryonic head mesoderm." [GOC:NV, PMID:17967061] is_a: CL:0000394 ! plasmatocyte is_a: CL:0011008 ! embryonic hemocyte [Term] id: CL:0011010 name: lateral mesodermal cell def: "A cell derived from the mesoderm that is found at the periphery of the embryo." [GOC:NV, PMID:9169844] subset: cellxgene_subset subset: human_subset subset: mouse_subset is_a: CL:0000222 ! mesodermal cell [Term] id: CL:0011011 name: intermediate mesodermal cell def: "A cell derived from the mesoderm that is located between the paraxial mesoderm and the lateral plate." [GOC:NV, ISBN:978-0-87969-707-5] subset: cellxgene_subset subset: human_subset subset: mouse_subset is_a: CL:0000222 ! mesodermal cell [Term] id: CL:0011012 name: neural crest cell def: "A cell of the neural crest. Neural crest cells are multipotent. Premigratory neural crest cells are found at the neural plate boarder, some of which will undergo ectomesynchymal transition and delamination to form migratory neural crest cells." [https://orcid.org/0000-0001-5208-3432, https://orcid.org/0000-0002-9900-7880] subset: cellxgene_subset subset: human_subset subset: mouse_subset is_a: CL:0000048 ! multi fate stem cell is_a: CL:0002321 ! embryonic cell (metazoa) property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0011012" xsd:string {name="neural crest cell on CELLxGENE CellGuide"} property_value: skos:prefLabel "neural crest cell" xsd:string property_value: terms:description "Neural crest cells are a group of transient and highly migratory cells that originate from the neuroectoderm during the early stages of embryonic development. They are multipotent cells with an exceptional degree of plasticity, capable of differentiating into various somatic cell types and therefore play a fundamental role in the formation of various organs and tissues, making them critical contributors to the developing embryo. \nAfter the initiation of neurulation (the formation of the neural tube) neural crest cells start to undergo epithelial-to-mesenchymal transition and delaminate and migrate from the dorsal neural tube to several regions throughout the embryo. They differentiate into a range of diverse cell types, such as neurons and glial cells of the peripheral nervous system, including sensory and autonomic neurons. They also contribute to the formation of adrenal glands, pigment cells in the skin (melanocytes), cardiac structures, including parts of the heart septum and major arteries, as well as bones and cartilage of the face and skull.\nDisorders or aberrations in the development or migration of the neural crest cells can lead to serious congenital malformations, such as neurocristopathies, including Hirschsprung disease, neuroblastoma, and neurofibromatosis.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1002/dvg.23276", xref="DOI:10.1242/dev.193193", xref="DOI:10.3389/fcell.2020.00635/full", xref="https://doi.org/10.1016/j.ydbio.2011.12.042"} [Term] id: CL:0011013 name: motile sperm cell def: "A sperm cell that is cabaple of motion (motility)." [PMID:30612620] subset: human_subset subset: mouse_subset is_a: CL:0000019 ! sperm is_a: CL:0000219 ! motile cell intersection_of: CL:0000019 ! sperm intersection_of: RO:0002215 GO:0097722 ! capable of sperm motility relationship: RO:0002215 GO:0097722 ! capable of sperm motility property_value: terms:contributor https://orcid.org/0000-0001-5208-3432 [Term] id: CL:0011014 name: non-motile sperm cell def: "A sperm cell that is not cabaple of motion (motility)." [PMID:30612620] subset: human_subset subset: mouse_subset is_a: CL:0000019 ! sperm property_value: terms:contributor https://orcid.org/0000-0001-5208-3432 [Term] id: CL:0011015 name: amoeboid sperm cell def: "A motile sperm cell that contain no F-actin, and their motility is powered by a dynamic filament system." [PMID:17708982] subset: human_subset subset: mouse_subset is_a: CL:0011013 ! motile sperm cell property_value: terms:contributor https://orcid.org/0000-0001-5208-3432 [Term] id: CL:0011016 name: flagellated sperm cell def: "A motile sperm cell that contains a slender threadlike microscopic appendage that enables motion." [https://www.lexico.com/en/definition/flagellum, PMID:30612620] subset: human_subset subset: mouse_subset is_a: CL:0011013 ! motile sperm cell intersection_of: CL:0011013 ! motile sperm cell intersection_of: RO:0002215 GO:0030317 ! capable of flagellated sperm motility relationship: RO:0002215 GO:0030317 ! capable of flagellated sperm motility property_value: terms:contributor https://orcid.org/0000-0001-5208-3432 [Term] id: CL:0011017 name: vagal neural crest cell def: "Cell that is part of the vagal neural crest population. The vagal neural crest arises from the axial level of somites 1-7 and has been described as a hybrid between the head and the trunk populations." [PMID:22016183] subset: human_subset subset: mouse_subset is_a: CL:0011012 ! neural crest cell property_value: terms:contributor https://orcid.org/0000-0001-5208-3432 [Term] id: CL:0011018 name: lymphoid tissue–inducer cell def: "A group 3 innate lymphoid cell that express ROR gamma t and IL-7R alpha in the absence of lineage markers (e.g. CD3, CD19, B220, CD11c, Gr-1), with the functional ability to interact with mesenchymal cells through lymphotoxin and tumor necrosis factor. Lymphoid tissue-inducer cells are key to the development of lymph nodes and Peyer’s patches." [GOC:add, PMID:19029905, PMID:21601793, PMID:27935637, PMID:29454785, PMID:9354470] subset: human_subset subset: mouse_subset synonym: "LTi" EXACT [] synonym: "lymphoid tissue inducer cell" EXACT [] is_a: CL:0001071 ! group 3 innate lymphoid cell relationship: RO:0002104 PR:000001869 ! has plasma membrane part interleukin-7 receptor subunit alpha property_value: terms:contributor https://orcid.org/0000-0001-5208-3432 [Term] id: CL:0011019 name: mesothelial cell of epicardium def: "A mesothelial cell that is part of the epicardium." [] subset: cellxgene_subset subset: human_subset subset: mouse_subset is_a: CL:0000077 ! mesothelial cell is_a: CL:0002494 ! cardiocyte intersection_of: CL:0000077 ! mesothelial cell intersection_of: BFO:0000050 UBERON:0002348 ! part of epicardium relationship: BFO:0000050 UBERON:0002348 ! part of epicardium property_value: terms:contributor https://orcid.org/0000-0001-5208-3432 [Term] id: CL:0011020 name: neural progenitor cell def: "An undifferentiated cell derived from a neural stem cell, with a limited capacity to self-renew (Dibajnia and Morshead, 2013) and the ability to generate multiple types of lineage-restricted progenitors, contributing to the formation of neurons, astrocytes, and oligodendrocytes." [PMID:23064725, PMID:30574073, PMID:37508487] subset: cellxgene_subset subset: human_subset subset: mouse_subset is_a: CL:0011026 ! progenitor cell relationship: RO:0002202 CL:0000047 ! develops from neural stem cell property_value: terms:contributor https://orcid.org/0000-0001-5208-3432 [Term] id: CL:0011021 name: fibroblast of upper back skin def: "A fibroblast that is part of upper back skin." [] subset: human_subset subset: mouse_subset is_a: CL:0011022 ! fibroblast of skin of back intersection_of: CL:0000057 ! fibroblast intersection_of: BFO:0000050 UBERON:0009015 ! part of upper back skin relationship: BFO:0000050 UBERON:0009015 ! part of upper back skin property_value: terms:contributor https://orcid.org/0000-0001-5208-3432 [Term] id: CL:0011022 name: fibroblast of skin of back def: "A fibroblast that is part of skin of back." [] subset: human_subset subset: mouse_subset is_a: CL:0002620 ! skin fibroblast intersection_of: CL:0000057 ! fibroblast intersection_of: BFO:0000050 UBERON:0001068 ! part of skin of back relationship: BFO:0000050 UBERON:0001068 ! part of skin of back property_value: terms:contributor https://orcid.org/0000-0001-5208-3432 [Term] id: CL:0011023 name: CD25+ mast cell def: "A mast cell that is CD25+." [] comment: Mast cells do not normally express CD25, but neoplastic mast cells may be CD25-positive. subset: human_subset subset: mouse_subset synonym: "CD25+ neoplastic mast cell" EXACT [] is_a: CL:0001063 ! neoplastic cell intersection_of: CL:0001063 ! neoplastic cell intersection_of: RO:0001000 CL:0000097 ! derives from mast cell intersection_of: RO:0002104 PR:000001380 ! has plasma membrane part interleukin-2 receptor subunit alpha relationship: RO:0001000 CL:0000097 ! derives from mast cell relationship: RO:0002104 PR:000001380 ! has plasma membrane part interleukin-2 receptor subunit alpha property_value: terms:contributor https://orcid.org/0000-0001-5208-3432 [Term] id: CL:0011024 name: double negative T regulatory cell def: "A double negative thymocyte that is CD3-positive, CD4-negative, CD8-negative, that that are present in the periphery in very low numbers and predominantly produce INF-gamma, TNF-alpha, and a low amount of TGF-beta, but not IL-2, IL-4, IL-10 or IL-13 upon activation." [PMID:16285891] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "CD4-negative, CD8-negative, alpha-beta regulatory T cells" EXACT [] synonym: "DN Treg" EXACT [] synonym: "double-negative alpha-beta regulatory T cell" EXACT [] is_a: CL:0002489 ! double negative thymocyte intersection_of: CL:0002489 ! double negative thymocyte intersection_of: RO:0002215 GO:0050777 ! capable of negative regulation of immune response relationship: RO:0002215 GO:0050777 ! capable of negative regulation of immune response property_value: terms:contributor https://orcid.org/0000-0001-5208-3432 [Term] id: CL:0011025 name: exhausted T cell def: "An effector T cell that displays impaired effector functions (e.g., rapid production of effector cytokines, cytotoxicity) and has limited proliferative potential." [PMID:26544946] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "Tex cell" EXACT [] is_a: CL:0000911 ! effector T cell property_value: terms:contributor https://orcid.org/0000-0001-5208-3432 [Term] id: CL:0011026 name: progenitor cell def: "A precursor cell that has a tendency to differentiate into a specific type of cell. They are descendants of stem cells, only they are more constrained in their differentiation potential or capacity for self-renewal, and are often more limited in both senses." [https://doi.org/10.1016/B978-0-12-409503-8.00002-0, ISBN:978-1-62808-994-3] subset: cellxgene_subset subset: human_subset subset: mouse_subset is_a: BFO:0000002 is_a: CL:0000255 ! eukaryotic cell is_a: CL:0011115 ! precursor cell intersection_of: CL:0011115 ! precursor cell intersection_of: RO:0002202 CL:0000034 ! develops from stem cell relationship: RO:0002202 CL:0000034 ! develops from stem cell property_value: skos:prefLabel "progenitor cell" xsd:string property_value: terms:contributor https://orcid.org/0000-0001-5208-3432 [Term] id: CL:0011027 name: skeletal muscle fibroblast def: "Any fibroblast that is part of skeletal muscle tissue." [https://orcid.org/0000-0001-6164-0667, PMID:28369879] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "skeleton muscle fibroblast" EXACT [] is_a: CL:0000188 ! cell of skeletal muscle is_a: CL:1001609 ! muscle fibroblast intersection_of: CL:0000057 ! fibroblast intersection_of: BFO:0000050 UBERON:0001134 ! part of skeletal muscle tissue property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0011027" xsd:string {name="skeletal muscle fibroblast on CELLxGENE CellGuide"} property_value: terms:contributor https://orcid.org/0000-0001-5208-3432 property_value: terms:description "Skeletal muscle fibroblasts (SMFs), with their spindle-shaped morphology, play a crucial role in maintaining the structure and function of skeletal muscles. They produce connective tissues enveloping muscle fibers, offering vital structural support for optimal muscle contraction. SMFs are integral components of the dynamic and complex microenvironment of muscle tissue, contributing significantly to healthy muscle development and homeostasis.\nSMFs primarily synthesize and secrete extracellular matrix (ECM) components, such as collagen, fibronectin, and proteoglycans. The resulting ECM exhibits mechanical properties that resist tensile forces from muscle contractions, ensuring muscle efficiency. It also crucially transmits force during muscle movement, aids muscle attachment to the skeletal structure, and serves as a scaffold for muscle regeneration and repair. \nFollowing injury, they proliferate and transform into myofibroblasts, aiding wound contraction and depositing new ECM for tissue repair. Additionally, these fibroblasts modulate inflammatory responses by secreting cytokines and interact with other cell types, like immune cells and satellite cells, to coordinate muscle healing. In diseases, an imbalance in SMF activity may lead to conditions such as fibrosis, marked by excessive ECM deposition and impaired muscle function.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1016/j.diff.2016.05.007", xref="DOI:10.1186/s13578-021-00579-4", xref="DOI:10.1186/s13578-022-00856-w"} [Term] id: CL:0011028 name: olfactory ensheathing cell def: "A neural-crest derived glial cell that supports the growth and survival of primary olfactory neuroons from the neuroepithelium in the nasal cavity to the brain by encasing large bundles of numerous unmyelinated axons." [PMID:22456085] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "OEC" EXACT [] xref: BTO:0002771 is_a: CL:0000125 ! glial cell property_value: terms:contributor https://orcid.org/0000-0001-5208-3432 [Term] id: CL:0011029 name: cnidocyte def: "An explosive cell containing one giant secretory organelle called a cnidocyst (also known as a cnida (plural cnidae) or nematocyst) that contains a toxin responsible for the stings delivered by a cnidarian to other organisms. Cnidae are used to capture prey and as a defense against predators. The presence of cnidocytes defines the phylum Cnidaria (corals, sea anemones, hydrae, jellyfish, etc.)." [https://en.wikipedia.org/wiki/Cnidocyte, https://orcid.org/0000-0002-2825-0621] synonym: "cnidoblast" EXACT [] synonym: "nematocyte" EXACT [] is_a: CL:0000151 ! secretory cell is_a: CL:0000255 ! eukaryotic cell relationship: BFO:0000051 GO:0042151 ! has part nematocyst relationship: RO:0002162 NCBITaxon:6073 ! in taxon Cnidaria property_value: terms:contributor https://orcid.org/0000-0001-5208-3432 [Term] id: CL:0011030 name: dermal microvascular endothelial cell def: "Any microvascular endothelial cell that is part of the dermis." [BTO:0004574, CL:patterns/cellPartOfAnatomicalEntity] subset: human_subset subset: mouse_subset synonym: "dermal microvascular endothelium cell" EXACT [] synonym: "DMEC cell" EXACT [] is_a: CL:2000008 ! microvascular endothelial cell is_a: CL:2000010 ! dermis blood vessel endothelial cell intersection_of: CL:2000008 ! microvascular endothelial cell intersection_of: BFO:0000050 UBERON:0002067 ! part of dermis property_value: terms:contributor https://orcid.org/0000-0001-5208-3432 [Term] id: CL:0011031 name: monocyte-derived dendritic cell def: "A dendritic cell that develops from a monocyte." [BTO:0002900, PMID:30719026, PMID:32733468] subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "MDDC cell" EXACT [] is_a: CL:0000782 ! myeloid dendritic cell relationship: RO:0002202 CL:0000576 ! develops from monocyte property_value: RO:0002175 NCBITaxon:9606 property_value: terms:contributor https://orcid.org/0000-0001-5208-3432 [Term] id: CL:0011032 name: lysosome-rich enterocyte def: "An enterocyte that possesses a large supranuclear vacuolar system that preferentially internalizes dietary protein via receptor-mediated and fluid-phase endocytosis for intracellular digestion and trans-cellular transport. In zebrafish these cells are located in the posterior region of the mid intestine throughout life. In mammals they are found in the ileum pre-weaning and later are replaced by mature enterocytes." [https://orcid.org/0000-0002-1009-339X, https://orcid.org/0000-0002-2244-7917, PMID:31474562] subset: human_subset subset: mouse_subset synonym: "early enterocyte" RELATED [https://orcid.org/0000-0001-9610-7627, PMID:33290721] synonym: "immature enterocyte" RELATED [https://orcid.org/0000-0001-9610-7627, PMID:33290721] synonym: "LRE" EXACT [] synonym: "vacuolated enterocyte" BROAD [] is_a: CL:0000584 ! enterocyte property_value: terms:contributor https://orcid.org/0000-0001-5208-3432 [Term] id: CL:0011100 name: galanergic neuron def: "Neuron that secretes the neurotransmitter galanin." [GOC:NV, PMID:23159249, ZFIN:CVS, ZFIN:YB] subset: human_subset subset: mouse_subset is_a: CL:0000540 ! neuron [Term] id: CL:0011101 name: chorionic trophoblast cell def: "Cells of the uterine chorion that acquire specialized structural and/or functional features that characterize chorionic trophoblasts. These cells will migrate towards the spongiotrophoblast layer and give rise to syncytiotrophoblasts of the labyrinthine layer." [GOC:NV] subset: cellxgene_subset subset: human_subset subset: mouse_subset is_a: CL:0000351 ! trophoblast cell intersection_of: CL:0000351 ! trophoblast cell intersection_of: BFO:0000050 UBERON:0003124 ! part of chorion membrane relationship: BFO:0000050 UBERON:0003124 ! part of chorion membrane property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0011101" xsd:string {name="chorionic trophoblast cell on CELLxGENE CellGuide"} property_value: terms:description "The chorionic trophoblast cell, vital for placental development in mammals, originates from the blastocyst's outer layer, the trophectoderm. As a significant component of the placenta, the chorion forms the external fetal-maternal interface and consists primarily of chorionic trophoblast cells. These cells are pivotal in embryogenesis, fetal nutrition, waste removal, and immune response generation, contributing crucially to the success of pregnancy.\nChorionic trophoblast cells undergo trophoblast differentiation, giving rise to specialized sub-types: cytotrophoblasts and syncytiotrophoblasts. Cytotrophoblasts, found in the inner layer, serve as stem cells and contribute to proliferative activities. In contrast, syncytiotrophoblasts, originating from cytotrophoblasts, form the outer layer with a distinctive multinucleated, continuous, and non-proliferative structure. These cells play a key role in maternal-fetal gas and nutrient exchange, producing essential hormones like human chorionic gonadotropin (hCG), progesterone, and estrogen, vital for sustaining pregnancy.\nApart from their physiological roles, chorionic trophoblast cells play a crucial role in shielding the fetus from the maternal immune system. They accomplish this by modifying the expression of major histocompatibility complex (MHC) molecules, which are self-identifying proteins utilized by the immune system to identify foreign cells. Through selective expression of specific types of these molecules, trophoblast cells can evade cytotoxic T cells that might otherwise attack them, while still retaining the ability to attract natural killer cells. These natural killer cells assist in trophoblast invasion and the remodeling of blood vessels in the uterus.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1007/s00018-019-03104-6", xref="DOI:10.1093/biolre/ioy070", xref="DOI:10.1155/2014/579279", xref="https://www.ncbi.nlm.nih.gov/books/NBK53245/", xref="https://www.sciencedirect.com/topics/medicine-and-dentistry/placenta-development"} [Term] id: CL:0011102 name: parasympathetic neuron def: "Parasympathetic neurons are part of the parasympathetic nervous sysem and the cell bodies lie in the brain and sacral region of the spinal cord. The neurons are mainly cholinergic." [GOC:NV, isbn:0080923437] subset: cellxgene_subset subset: human_subset subset: mouse_subset xref: ZFA:0005776 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000107 ! autonomic neuron [Term] id: CL:0011103 name: sympathetic neuron def: "Sympathetic neurons are part of the sympathetic nervous system and are primarily adrenergic producing the neurotransmitter noradrenalin along with other neuropeptides." [GOC:NV, isbn:0080923437] subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset xref: ZFA:0005777 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000107 ! autonomic neuron property_value: RO:0002175 NCBITaxon:9606 property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0011103" xsd:string {name="sympathetic neuron on CELLxGENE CellGuide"} property_value: terms:description "Sympathetic neurons are a distinct class of neurons that are an integral part of the autonomic nervous system, specifically within the sympathetic division. They play a critical role in the body's 'fight or flight' responses and are primarily involved in regulating involuntary physiological processes, such as heart rate, blood pressure, body temperature, and metabolic processes. These neurons are essential for homeostatic mechanisms, working to ensure a balanced state is maintained within the body amidst changing environments.\nStructurally, sympathetic neurons are characterized by their relatively long axons, which allow them to relay signals from the central nervous system to various peripheral organs and tissues. They typically originate within the spinal cord's thoracic and lumbar regions, extending their axons to connect with various targets, including cardiac muscle, smooth muscle, and glands. These neurons often utilize noradrenaline (norepinephrine) as a neurotransmitter, which binds to adrenergic receptors on the target cells to exert their effects.\nFunctionally, the sympathetic neurons help the body respond to stressful or threatening situations. When activated, they provoke a cascade of processes that ready the body for quick action. This includes accelerating the heart rate, dilating the pupils, slowing digestion, and increasing blood flow to muscles. Conversely, when the threat has passed, they encourage a return to normalcy by inhibiting these same processes. Beyond this 'fight or flight' response, sympathetic neurons also function to help regulate body temperature by inducing sweating or shivering, influence the dilation of blood vessels to control blood pressure, and can stimulate the release of glucose from the liver to provide energy. Overall, sympathetic neurons are key mediators of the body's response to various internal and external stimuli, maintaining homeostasis and preparing the body for diverse challenges.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1023/A:1009889922985", xref="DOI:10.1038/s41583-021-00523-y", xref="DOI:10.1146/annurev.neuro.22.1.541", xref="DOI:10.1152/physrev.00005.2023", xref="DOI:10.1161/HYPERTENSIONAHA.111.00633"} [Term] id: CL:0011104 name: interplexiform cell def: "A type of interneuron in the retinal inner nuclear layer which\ncarries information from the inner plexiform layer and the outer\nplexiform layer." [GOC:NV, PMID:12771169] comment: Need to MIREOT retinal inner nuclear layer (part of) subset: eye_upper_slim subset: human_subset subset: mouse_subset is_a: CL:0000099 ! interneuron is_a: CL:0000748 ! retinal bipolar neuron relationship: BFO:0000050 UBERON:0001791 ! part of inner nuclear layer of retina [Term] id: CL:0011105 name: dopamanergic interplexiform cell def: "A type of interneuron in the retinal inner nuclear layer which\ncarries information from the inner plexiform layer and the outer\nplexiform layer, using dopamine." [GOC:NV, PMID:12771169] comment: This type of cell is found in Danio rerio. subset: human_subset subset: mouse_subset is_a: CL:0000700 ! dopaminergic neuron is_a: CL:0011104 ! interplexiform cell intersection_of: CL:0011104 ! interplexiform cell intersection_of: RO:0002215 GO:0061527 ! capable of dopamine secretion, neurotransmission [Term] id: CL:0011106 name: GABAnergic interplexiform cell def: "A type of interneuron in the retinal inner nuclear layer which\ncarries information from the inner plexiform layer and the outer\nplexiform layer using GABA." [GOC:NV, PMID:12771169] comment: This type of cell is found in many mammals. subset: human_subset subset: mouse_subset is_a: CL:0008060 ! GABA-Glut neuron is_a: CL:0011005 ! GABAergic interneuron is_a: CL:0011104 ! interplexiform cell intersection_of: CL:0011104 ! interplexiform cell intersection_of: RO:0002215 GO:0061534 ! capable of gamma-aminobutyric acid secretion, neurotransmission [Term] id: CL:0011107 name: obsolete Muller cell def: "OBSOLETE: Astrocyte-like radial glial cell that extends vertically throughout the retina, with the nucleus are usually in the middle of the inner nuclear layer." [GOC:NV, PMID:21911394] comment: Term was duplicated, use CL:0000636 instead synonym: "Muller glia" EXACT [] synonym: "Müller cell" EXACT [] is_obsolete: true replaced_by: CL:0000636 [Term] id: CL:0011108 name: colon epithelial cell def: "Epithelial cell that is part of the colon epithelium." [GOC:NV] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "colonic epithelial cell" EXACT [] is_a: CL:0002253 ! epithelial cell of large intestine intersection_of: CL:0000066 ! epithelial cell intersection_of: BFO:0000050 UBERON:0000397 ! part of colonic epithelium relationship: BFO:0000050 UBERON:0000397 ! part of colonic epithelium [Term] id: CL:0011109 name: hypocretin-secreting neuron def: "A neuron that releases hypocretin as a neurotransmitter." [GOC:NV, PMID:23848055] subset: human_subset subset: mouse_subset synonym: "orexin" EXACT [] xref: ZFA:0005778 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000151 ! secretory cell is_a: CL:0000540 ! neuron intersection_of: CL:0000540 ! neuron intersection_of: RO:0002215 GO:0061585 ! capable of orexin secretion, neurotransmission relationship: RO:0002215 GO:0061585 ! capable of orexin secretion, neurotransmission [Term] id: CL:0011110 name: histaminergic neuron def: "Neuron that secretes histamine." [GOC:NV, PMID:22677810] subset: human_subset subset: mouse_subset xref: FBbt:00007367 {sssom:mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"} is_a: CL:0000540 ! neuron is_a: CL:0002274 ! histamine secreting cell intersection_of: CL:0000540 ! neuron intersection_of: RO:0002215 GO:0061538 ! capable of histamine secretion, neurotransmission relationship: RO:0002215 GO:0061538 ! capable of histamine secretion, neurotransmission [Term] id: CL:0011111 name: hypothalamic gonadotropin-releasing hormone neuron def: "a specialized neuroendocrine cell that synthesizes and secretes GnRH decapeptide, a key regulator of reproductive function. It originates from the olfactory placode during embryonic development and migrates into the forebrain where it localises predominantly in the hypothalamus and in humans, in extrahypothalamic regions like the basal ganglia (Skrapits et al., 2021). This cell regulates reproduction by secreting GnRH into the pituitary portal vessels to induce the release of gonadotropins into the general circulation. It expresses receptor subunits required for AMPA, NMDA, and kainate receptor signaling and may use glutamate as a neurotransmitter in recurrent collateral innervation." [GOC:NV, PMID:20807514, PMID:21828096, PMID:26053743, PMID:34128468, PMID:35067985] subset: human_subset subset: mouse_subset synonym: "GnRH neuron" EXACT [] synonym: "GnRH-secreting neuron" EXACT [] is_a: CL:0000165 ! neuroendocrine cell is_a: CL:0012001 ! neuron of the forebrain relationship: RO:0002596 GO:0032274 ! capable of regulating gonadotropin secretion [Term] id: CL:0011112 name: obsolete magnocellular neurosecretory cell def: "OBSOLETE: Neurons part of the hypothalamic supraoptic and paraventricular nuclei that secrete the hormones, oxytocin and vasopressin into the systemic circulation from the posterior pituitary gland." [GOC:NV, PMID:10711808] comment: Duplicated term, please see CL:0011003 instead is_obsolete: true replaced_by: CL:0011003 [Term] id: CL:0011113 name: spiral ganglion neuron def: "Neuron found in the spiral ganglion." [GOC:NV] subset: cellxgene_subset subset: human_subset subset: mouse_subset is_a: BFO:0000002 is_a: CL:2000032 ! peripheral nervous system neuron intersection_of: CL:2000032 ! peripheral nervous system neuron intersection_of: RO:0002100 UBERON:0000395 ! has soma location cochlear ganglion relationship: RO:0002100 UBERON:0000395 ! has soma location cochlear ganglion [Term] id: CL:0011114 name: segmented neutrophil of bone marrow def: "A segmented neutrophilic cell of the bone marrow reserve pool that expresses CD11b (integrin alpha-M) and high levels of CD16 (low affinity immunoglobulin gamma Fc region receptor III) on its cell surface." [PMID:11138622, PMID:15514007] subset: human_subset subset: mouse_subset is_a: CL:0000096 ! mature neutrophil is_a: CL:1001610 ! bone marrow hematopoietic cell [Term] id: CL:0011115 name: precursor cell def: "A cell that, by division or terminal differentiation, can give rise to other cell types." [GOC:dos] comment: Work is needed on GO 'cell differentiation' before it is clear whether the equivalent class definition 'native cell' that capable_of some 'cell differentiation' works. Also, may want to consider merging this with non-terminally differentiated cell. subset: cellxgene_subset subset: human_subset subset: mouse_subset is_a: CL:0000000 ! cell intersection_of: CL:0000000 ! cell intersection_of: RO:0002215 GO:0030154 ! capable of cell differentiation relationship: RO:0002215 GO:0030154 ! capable of cell differentiation property_value: skos:prefLabel "precursor cell" xsd:string [Term] id: CL:0012000 name: astrocyte of the forebrain def: "An astrocyte of the forebrain." [] subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "forebrain astrocyte" EXACT [] is_a: CL:0000127 {is_inferred="true"} ! astrocyte is_a: CL:2000005 ! brain macroglial cell intersection_of: CL:0000127 ! astrocyte intersection_of: BFO:0000050 UBERON:0001890 ! part of forebrain relationship: BFO:0000050 UBERON:0001890 ! part of forebrain property_value: RO:0002175 NCBITaxon:9606 property_value: terms:contributor https://orcid.org/0000-0002-3837-8864 [Term] id: CL:0012001 name: neuron of the forebrain def: "A CNS neuron of the forebrain." [] subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "forebrain neuron" EXACT [] is_a: CL:2000029 ! central nervous system neuron intersection_of: CL:0000540 ! neuron intersection_of: RO:0002100 UBERON:0001890 ! has soma location forebrain relationship: RO:0002100 UBERON:0001890 ! has soma location forebrain property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "neuron of the forebrain" xsd:string property_value: terms:contributor https://orcid.org/0000-0002-3837-8864 [Term] id: CL:0013000 name: forebrain radial glial cell def: "Any radial glial cell that is part of some forebrain." [FBC:Autogenerated] subset: cellxgene_subset subset: human_subset subset: mouse_subset is_a: CL:0000681 ! radial glial cell intersection_of: CL:0000681 ! radial glial cell intersection_of: BFO:0000050 UBERON:0001890 ! part of forebrain relationship: BFO:0000050 UBERON:0001890 ! part of forebrain property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0013000" xsd:string {name="forebrain radial glial cell on CELLxGENE CellGuide"} property_value: terms:description "Forebrain radial glial cells are specialized cells in the central nervous system known for their essential role in the formation of the brain during neurodevelopment. These cells are primarily located in the ventricular zone of the developing forebrain, which is composed of the cerebrum and the diencephalon. Radial glial cells are named for their unique morphology, specifically their elongated cell bodies, which extend radially from the ventricular surface to the pial surface, acting as a scaffold for newborn neurons to migrate along during the development of the brain.\nFunctionally, forebrain radial glial cells serve as both progenitor cells and guide cells for neurons. They proliferate to increase their population and produce neurons or glial cells through asymmetric division, contributing to the complexity and diversity of cell types in the brain. During neurogenesis, an important process in brain development, radial glial cells provide physical and biochemical guidance to newborn neurons, helping them migrate from their birthplace in the ventricular zone to their final destination in the cortical plate.\nFurthermore, forebrain radial glial cells play a critical role in the formation of the cerebral cortex layers through their interaction with newborn neurons. They are involved in the establishment of the six-layered architecture of the cerebral cortex, crucial to higher cognitive functions, sensory processing, and control of motor behavior. After completing their roles in neurogenesis and the formation of cortical layers, most radial glial cells transform into astrocytes or oligodendrocytes, the main glial cell types in the mature brain. Thus, from their contribution to the proliferation and differentiation of neurons to the establishment of cortical layering, forebrain radial glial cells perform several fundamental roles in brain development.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1002/glia.10244", xref="DOI:10.1016/S0070-2153(05)69004-7", xref="DOI:10.1016/j.biocel.2013.11.013", xref="DOI:10.1016/j.neuron.2016.09.005", xref="DOI:10.1038/35055553"} [Term] id: CL:0015000 name: cranial motor neuron def: "Motor neuron that innervate muscles that control eye, jaw, and facial movements of the vertebrate head and parasympathetic neurons that innervate certain glands and organs." [ZFIN:CVS] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "cranial motoneuron" EXACT [] xref: PMID:14699587 xref: ZFA:0005730 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000100 ! motor neuron [Term] id: CL:0017000 name: pulmonary ionocyte def: "An ionocyte that is part of the lung epithelium. The cells from this type are major sources of the CFTR protein in human and mice." [PMID:30069044, PMID:30069046] comment: The marker set ASCL3, BSND can identify the Human cell type pulmonary ionocyte in the lung with a confidence of 0.82 (NS-Forest FBeta value). {xref="https://doi.org/10.5281/zenodo.11165918"} subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset is_a: CL:0000082 ! epithelial cell of lung is_a: CL:0005006 ! ionocyte intersection_of: CL:0005006 ! ionocyte intersection_of: BFO:0000050 UBERON:0000115 ! part of lung epithelium relationship: RO:0015004 CLM:1000032 ! has characterizing marker set NS forest marker set of pulmonary ionocyte (Human lung). property_value: RO:0002175 NCBITaxon:9606 property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0017000" xsd:string {name="pulmonary ionocyte on CELLxGENE CellGuide"} property_value: terms:contributor https://orcid.org/0000-0003-2473-2313 property_value: terms:description "The pulmonary ionocyte is a relatively newly identified, specific epithelial cell type found primarily in the pulmonary or respiratory system. Discovered through novel mapping techniques in 2018, these cells are surprisingly rare, making up less than 2% of the cells in the lung's airway, yet they play an essential role in the airway surface liquid and mucus regulation, a crucial factor in lung health.\nThe main responsibility of the pulmonary ionocyte pertains to the regulation and mobilization of chloride ions. They express a high level of CFTR (Cystic Fibrosis Transmembrane Conductance Regulator) gene, which encodes a protein channel across the membrane of cells that produce mucus, sweat, saliva, tears, and digestive enzymes. The activity of CFTR regulates the movement of chloride ions and fluids in and out of cells, which helps maintain a balance of fluid in the organs they are expressed in. If CFTR is dysfunctional, it can cause conditions such as cystic fibrosis, characterized by thick, sticky mucus that can clog the lungs and obstruct the pancreas, leading to respiratory and digestive issues.\nThe discovery of this cell type offers new doors to the treatment and further understanding of diseases like cystic fibrosis. Increased understanding of pulmonary ionocytes could contribute to the development of novel therapeutic approaches to manipulate the function of CFTR in the lungs and other organs affected by dysfunctional CFTR.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1038/s41586-018-0393-7", xref="DOI:10.1146/annurev-pathol-042420-094031", xref="DOI:10.1172/JCI171268"} [Term] id: CL:0017001 name: splanchnic mesodermal cell def: "A mesodermal cell that is part of the splanchnic layer of lateral plate mesoderm." [] subset: cellxgene_subset subset: human_subset subset: mouse_subset is_a: CL:0011010 ! lateral mesodermal cell relationship: BFO:0000050 UBERON:0004872 ! part of splanchnic layer of lateral plate mesoderm property_value: terms:contributor https://orcid.org/0000-0003-2473-2313 [Term] id: CL:0017002 name: prostate neuroendocrine cell def: "A neuroendocrine cell that is part of the prostate epithelium." [http://orcid.org/0000-0001-7772-9578, PMID:33842835] subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "neuroendocrine cell of prostate epithelium" EXACT [] synonym: "neuroendocrine cell of the prostate" EXACT [] is_a: CL:0000150 ! glandular secretory epithelial cell is_a: CL:0000165 ! neuroendocrine cell intersection_of: CL:0000165 ! neuroendocrine cell intersection_of: BFO:0000050 UBERON:0000428 ! part of prostate epithelium relationship: BFO:0000050 UBERON:0000428 ! part of prostate epithelium property_value: RO:0002175 NCBITaxon:9606 property_value: terms:contributor http://orcid.org/0000-0003-2473-2313 [Term] id: CL:0017003 name: epithelial cell of prostatic urethra def: "An epithelial cell that is part of the prostatic urethra." [PMID:30566875] subset: human_subset subset: mouse_subset is_a: CL:1000296 ! epithelial cell of urethra intersection_of: CL:0000066 ! epithelial cell intersection_of: BFO:0000050 UBERON:0001335 ! part of prostatic urethra relationship: BFO:0000050 UBERON:0001335 ! part of prostatic urethra property_value: terms:contributor http://orcid.org/0000-0003-2473-2313 [Term] id: CL:0017004 name: telocyte def: "A supportive cell with a small, oval-shaped body and one to five telopodes. Telopodes are cytoplasmic protrusions from tens to hundreds of micrometers long and mostly below 0.2 microns of caliber." [https://en.wikipedia.org/wiki/Telocyte, MESH:D000067170, PMID:20367664, PMID:28714595, PMID:31311805] comment: Telocytes manage to develop complex networks in almost all organs of the human body. Although staining positively for vimentin antibody, some uncertainty still persists over the mesenchymal origin of these cells. {xref="https://doi.org/10.1016/B978-0-12-818561-2.00001-1"} subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "ICLC" RELATED [PMID:20367664] synonym: "interstitial Cajal cell-like cell" NARROW [PMID:20367664] synonym: "interstitial Cajal-like cell" NARROW [PMID:20367664] synonym: "interstitial neuron" RELATED [PMID:31311805] is_a: CL:0002320 ! connective tissue cell relationship: BFO:0000051 GO:0120327 ! has part telopode property_value: RO:0002175 NCBITaxon:9606 property_value: terms:contributor http://orcid.org/0000-0003-2473-2313 [Term] id: CL:0017005 name: lymphoblast def: "A lymphocyte that has gotten larger after being stimulated by an antigen." [http://orcid.org/0000-0001-9990-8331, NCIT:C13013] subset: blood_and_immune_upper_slim subset: human_subset subset: mouse_subset xref: BTO:0000772 xref: EFO:0000572 xref: FMA:83030 is_a: CL:0000542 ! lymphocyte relationship: RO:0002353 GO:0046649 ! output of lymphocyte activation property_value: terms:contributor http://orcid.org/0000-0003-2473-2313 property_value: terms:date "2022-08-17T14:20:01Z" xsd:dateTime [Term] id: CL:0017006 name: B-lymphoblast def: "A lymphocyte of B lineage that has gotten larger after being stimulated by an antigen." [EFO:0005293, https://orcid.org/0000-0002-2825-0621] subset: blood_and_immune_upper_slim subset: human_subset subset: mouse_subset xref: EFO:0005293 xref: FMA:83031 is_a: CL:0000945 ! lymphocyte of B lineage is_a: CL:0017005 ! lymphoblast property_value: terms:contributor http://orcid.org/0000-0003-2473-2313 property_value: terms:date "2022-08-17T14:30:32Z" xsd:dateTime [Term] id: CL:0017009 name: Axl+ dendritic cell, human def: "A human dendritic cell that expresses the AXL and SIGLEC6 genes." [PMID:28428369, PMID:29221729, PMID:31156637] subset: cellxgene_subset subset: human_subset synonym: "AS DC, human" EXACT [] is_a: CL:0001056 ! dendritic cell, human relationship: RO:0002292 PR:O43699 ! expresses sialic acid-binding Ig-like lectin 6 (human) relationship: RO:0002292 PR:P30530 ! expresses tyrosine-protein kinase receptor UFO (human) property_value: terms:contributor http://orcid.org/0000-0003-2473-2313 property_value: terms:date "2022-08-25T14:18:37Z" xsd:dateTime [Term] id: CL:0017010 name: hillock cell of urethral epithelium def: "A hillock cell that is part of the urethra." [http://orcid.org/0000-0001-7772-9578, PMID:30566875] subset: human_subset subset: mouse_subset synonym: "hillock cell of urethra" EXACT [] is_a: CL:1000296 ! epithelial cell of urethra is_a: CL:4030024 ! hillock cell intersection_of: CL:4030024 ! hillock cell intersection_of: BFO:0000050 UBERON:0000057 ! part of urethra property_value: terms:contributor http://orcid.org/0000-0003-2473-2313 property_value: terms:date "2022-10-13T13:51:35Z" xsd:dateTime [Term] id: CL:0017011 name: hillock cell of prostatic urethral epithelium def: "A hillock cell that is part of the prostatic urethra." [http://orcid.org/0000-0001-7772-9578, PMID:30566875] subset: human_subset subset: mouse_subset synonym: "hillock cell of prostatic urethra" EXACT [] is_a: CL:0017003 ! epithelial cell of prostatic urethra is_a: CL:0017010 ! hillock cell of urethral epithelium intersection_of: CL:4030024 ! hillock cell intersection_of: BFO:0000050 UBERON:0001335 ! part of prostatic urethra property_value: terms:contributor http://orcid.org/0000-0003-2473-2313 property_value: terms:date "2022-10-13T13:58:15Z" xsd:dateTime [Term] id: CL:0017500 name: neutrophillic cytoplasm def: "Cytoplasm that exhibits a characteristic staining and color, pale-pink, with Wright-Giemsa stain." [GOC:add] is_a: GO:0005737 ! cytoplasm intersection_of: GO:0005737 ! cytoplasm intersection_of: RO:0000053 PATO:0070046 ! has characteristic neutrophillic relationship: RO:0000053 PATO:0070046 ! has characteristic neutrophillic property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-05-25T01:36:34Z [Term] id: CL:0017501 name: obsolete lobed nucleus def: "Nucleus with two or more lobes connected by a thin filament that contains no internal chromatin." [GOC:tfm] comment: Obsoleted because duplicate with GO term. property_value: IAO:0000233 https://github.com/obophenotype/cell-ontology/issues/734 property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 is_obsolete: true replaced_by: GO:0098537 creation_date: 2009-12-22T03:54:43Z [Term] id: CL:0017502 name: acidophilic cytoplasm def: "Cytoplasm that exhibits a characteristic staining and color, red or pink, with Eosin stain." [GOC:add] synonym: "eosinophilic" NARROW [] is_a: GO:0005737 ! cytoplasm intersection_of: GO:0005737 ! cytoplasm intersection_of: RO:0000053 PATO:0002418 ! has characteristic acidophilic relationship: RO:0000053 PATO:0002418 ! has characteristic acidophilic property_value: skos:prefLabel "acidophilic cytoplasm" xsd:string property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2009-12-22T04:23:25Z [Term] id: CL:0017503 name: basophilic cytoplasm def: "Cytoplasm that exhibits molecular interaction for basic dyes under specific pH conditions." [GOC:tfm] is_a: GO:0005737 ! cytoplasm intersection_of: GO:0005737 ! cytoplasm intersection_of: RO:0000053 PATO:0002094 ! has characteristic basophilic relationship: RO:0000053 PATO:0002094 ! has characteristic basophilic property_value: skos:prefLabel "basophilic cytoplasm" xsd:string property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2009-12-22T04:24:54Z [Term] id: CL:0017504 name: polychromatophilic cytoplasm def: "Cytoplasm that exhibits affinity for both basic and acid stains under specific pH conditions." [GOC:tfm] is_a: GO:0005737 ! cytoplasm intersection_of: GO:0005737 ! cytoplasm intersection_of: RO:0000053 PATO:0070047 ! has characteristic polychromatophilic relationship: RO:0000053 PATO:0070047 ! has characteristic polychromatophilic property_value: skos:prefLabel "polychromatophilic cytoplasm" xsd:string property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2009-12-28T04:25:23Z [Term] id: CL:0017505 name: obsolete increased nucleus size def: "OBSOLETE. A nucleus size quality which is relatively high compared to the amount of cytoplasm present in the same cell." [GOC:tfm] comment: This class was a phenotype, not a cell type. property_value: IAO:0000233 https://github.com/obophenotype/cell-ontology/issues/2251 property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 is_obsolete: true replaced_by: PATO:0040072 creation_date: 2009-12-23T10:53:24Z [Term] id: CL:0017506 name: banded nucleus def: "A concave nuclear shape where the nucleus is indented to more than half the distance to the farthest nuclear margin, but in no area is the chromatin condensed to a single filament." [GOC:tfm] is_a: GO:0005634 ! nucleus property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2009-12-23T02:18:43Z [Term] id: CL:0017507 name: reniform nucleus def: "A concave nucleus shape where the indentation is smaller than half of the distance to the farthest nuclear margin." [GOC:tfm] is_a: GO:0005634 ! nucleus intersection_of: GO:0005634 ! nucleus intersection_of: RO:0000053 PATO:0001871 ! has characteristic reniform relationship: RO:0000053 PATO:0001871 ! has characteristic reniform property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2009-12-23T02:31:25Z [Term] id: CL:0017508 name: cartwheel heterochromatin def: "Heterochromatin that is arranged in a carthwheel pattern." [GOC:tfm] is_a: GO:0000792 ! heterochromatin property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2009-12-28T04:28:35Z [Term] id: CL:0017509 name: alobate nucleus def: "Any nucleus that has characteristic some alobate." [FBC:Autogenerated] is_a: GO:0005634 ! nucleus intersection_of: GO:0005634 ! nucleus intersection_of: RO:0000053 PATO:0002506 ! has characteristic alobate relationship: RO:0000053 PATO:0002506 ! has characteristic alobate [Term] id: CL:0019001 name: tracheobronchial serous cell def: "Any serous secreting cell that is part of the tracheobronchial epithelium." [] subset: added_for_HCA subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "serous cell of tracheobronchial tree" EXACT [] is_a: CL:0000255 ! eukaryotic cell is_a: CL:0000313 ! serous secreting cell intersection_of: CL:0000313 ! serous secreting cell intersection_of: BFO:0000050 UBERON:0007196 ! part of tracheobronchial tree relationship: BFO:0000050 UBERON:0007196 ! part of tracheobronchial tree property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0019001" xsd:string {name="tracheobronchial serous cell on CELLxGENE CellGuide"} property_value: terms:contributor https://orcid.org/0000-0003-2034-601X property_value: terms:date "2020-05-07T16:03:27Z" xsd:dateTime property_value: terms:description "Serous cells of the tracheobronchial are found on the surface epithelium, submucosal glands, or both, depending on species. They appear in tubulo-acinar arrangements in submucosal glands.\nTracheobronchial serous cells play a vital role in maintaining respiratory health by secreting serous fluid, which is rich in enzymes, ions, and antimicrobial proteins. This serous fluid is essential in clearing out debris, trapping and neutralizing inhaled pathogens and particulate matters, thereby helping in preventing infections. Their secretory products also include water and electrolytes that, combined with mucus (from mucous cells), maintain proper humidity within the airway and lubricate its surfaces, facilitating unhindered airflow. Dysfunction of these cells may lead to diseases such as cystic fibrosis.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1016/j.resp.2007.06.017", xref="DOI:10.1113/jphysiol.2003.052779", xref="DOI:10.1146/annurev.ph.52.030190.000525", xref="DOI:10.1152/ajplung.00068.2019"} [Term] id: CL:0019002 name: tracheobronchial chondrocyte def: "Any chondrocyte that is part of the tracheobronchial tree." [] subset: added_for_HCA subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "chondrocyte of tracheobronchial tree" EXACT [] is_a: CL:0000138 ! chondrocyte intersection_of: CL:0000138 ! chondrocyte intersection_of: BFO:0000050 UBERON:0007196 ! part of tracheobronchial tree relationship: BFO:0000050 UBERON:0007196 ! part of tracheobronchial tree property_value: RO:0002175 NCBITaxon:9606 property_value: terms:contributor https://orcid.org/0000-0003-2034-601X property_value: terms:date "2020-05-07T17:29:51Z" xsd:dateTime [Term] id: CL:0019003 name: tracheobronchial goblet cell def: "Any goblet cell that is part of the tracheobronchial epithelium." [] subset: added_for_HCA subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "goblet cell of tracheobronchial tree" EXACT [] is_a: CL:0002202 ! epithelial cell of tracheobronchial tree is_a: CL:0002370 ! respiratory tract goblet cell intersection_of: CL:0000160 ! goblet cell intersection_of: BFO:0000050 UBERON:0008397 ! part of tracheobronchial epithelium property_value: RO:0002175 NCBITaxon:9606 property_value: terms:contributor https://orcid.org/0000-0003-2034-601X property_value: terms:date "2020-05-07T18:14:52Z" xsd:dateTime [Term] id: CL:0019015 name: lung parenchyma resident eosinophil def: "An eosinophil with a ring-shaped nucleus that is resident in the lung parenchyma. In mouse, lung parenchyma resident eosinophils are IL-5-independent Siglec-F(intermediate) CD62L+ CD101(low). In human, they are Siglec-8+ CD62L+ IL-3R(low)." [PMID:27548519] subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "lung-resident eosinophil" EXACT [PMID:27548519] synonym: "rEos" EXACT [PMID:27548519] is_a: CL:0000774 ! band form eosinophil intersection_of: CL:0000774 ! band form eosinophil intersection_of: BFO:0000050 UBERON:0008946 ! part of lung parenchyma relationship: BFO:0000050 UBERON:0008946 ! part of lung parenchyma property_value: RO:0002175 NCBITaxon:9606 property_value: terms:contributor https://orcid.org/0000-0003-2034-601X property_value: terms:date "2020-05-26T09:42:19Z" xsd:dateTime [Term] id: CL:0019017 name: lymphatic vessel smooth muscle cell def: "A smooth muscle cell that is part of any lymphatic vessel." [PMID:15109561] subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "smooth muscle cell of lymphatic vessel" EXACT [] is_a: CL:0000359 ! vascular associated smooth muscle cell intersection_of: CL:0000192 ! smooth muscle cell intersection_of: BFO:0000050 UBERON:0001473 ! part of lymphatic vessel relationship: BFO:0000050 UBERON:0001473 ! part of lymphatic vessel property_value: RO:0002175 NCBITaxon:9606 property_value: terms:contributor https://orcid.org/0000-0003-2034-601X property_value: terms:date "2020-07-21T12:29:51Z" xsd:dateTime [Term] id: CL:0019018 name: blood vessel smooth muscle cell def: "A smooth muscle cell that is part of any blood vessel." [PMID:9108778] subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "smooth muscle cell of blood vessel" EXACT [] is_a: CL:0000359 ! vascular associated smooth muscle cell intersection_of: CL:0000192 ! smooth muscle cell intersection_of: BFO:0000050 UBERON:0001981 ! part of blood vessel relationship: BFO:0000050 UBERON:0001981 ! part of blood vessel property_value: RO:0002175 NCBITaxon:9606 property_value: terms:contributor https://orcid.org/0000-0003-2034-601X property_value: terms:date "2020-07-21T12:42:48Z" xsd:dateTime [Term] id: CL:0019019 name: tracheobronchial smooth muscle cell def: "A smooth muscle cell that is part of the tracheobronchial tree." [PMID:10853867] comment: The marker set ACTA2, TAGLN can identify the Human cell type tracheobronchial smooth muscle cell in the lung with a confidence of 0.69 (NS-Forest FBeta value). {xref="https://doi.org/10.5281/zenodo.11165918"} subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "smooth muscle cell of tracheobronchial tree" EXACT [] is_a: CL:0000192 ! smooth muscle cell intersection_of: CL:0000192 ! smooth muscle cell intersection_of: BFO:0000050 UBERON:0007196 ! part of tracheobronchial tree relationship: BFO:0000050 UBERON:0007196 ! part of tracheobronchial tree relationship: RO:0015004 CLM:1000056 ! has characterizing marker set NS forest marker set of tracheobronchial smooth muscle cell (Human lung). property_value: RO:0002175 NCBITaxon:9606 property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0019019" xsd:string {name="tracheobronchial smooth muscle cell on CELLxGENE CellGuide"} property_value: terms:contributor https://orcid.org/0000-0003-2034-601X property_value: terms:date "2020-07-21T12:50:22Z" xsd:dateTime property_value: terms:description "Tracheobronchial smooth muscle cells are universally located in the tracheobronchial tree and play a critical role in controlling and modulating the size of the airway lumen, thereby contributing significantly to the airflow resistance. \nThese cells display both phasic and tonic characteristics, which are vital for airway contractility. Phasic activity manifests as cyclic contraction and relaxation, similar to the behavior seen in gastrointestinal smooth muscle cells, whilst tonic activity resembles vascular smooth muscle cells, maintaining a constant degree of tension. These features enable tracheobronchial smooth muscle cells to constrict the airways in response to various mechanical and chemical stimuli, including allergens, parasympathetic nervous stimulation, changes in gas composition, and cold air, thus protecting the delicate alveoli from potential damage.\nTracheobronchial smooth muscle cells, beyond their contractile function, actively contribute to airway remodeling in conditions like asthma. Their proliferative and synthetic capabilities lead to smooth muscle hypertrophy, hyperplasia, and the production of extracellular matrix components, collectively causing abnormal airway narrowing.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1007/978-3-540-79090-7_5", xref="DOI:10.1152/japplphysiol.00950.2012", xref="https://www.ncbi.nlm.nih.gov/books/NBK556044/"} [Term] id: CL:0019020 name: extrahepatic cholangiocyte def: "An epithelial cell of the extrahepatic bile ducts, including the left and right hepatic duct, common hepatic duct, and common bile duct. They are columnar in shape, and have a large nuclear-to-cytoplasmic ratio relative to small/intrahepatic cholangiocytes." [PMID:23720296] subset: human_subset subset: mouse_subset synonym: "large bile duct cholangiocyte" EXACT [PMID:23720296] is_a: CL:1000488 ! cholangiocyte intersection_of: CL:1000488 ! cholangiocyte intersection_of: BFO:0000050 UBERON:0004822 ! part of extrahepatic bile duct epithelium relationship: BFO:0000050 UBERON:0004822 ! part of extrahepatic bile duct epithelium property_value: terms:contributor https://orcid.org/0000-0003-2034-601X property_value: terms:date "2020-09-03T12:24:24Z" xsd:dateTime [Term] id: CL:0019021 name: endothelial cell of periportal hepatic sinusoid def: "An endothelial cell found in the periportal region hepatic sinusoid, near the portal triad. The fenestrae of these cells are larger but fewer in number compared with those of endothelial cells near the centrilobular region of the hepatic sinusoid." [PMID:27423426] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "periportal hepatic sinusoidal endothelial cell" EXACT [PMID:30348985] synonym: "periportal LSEC" EXACT [PMID:28287163] xref: EFO:0010705 is_a: CL:1000398 ! endothelial cell of hepatic sinusoid intersection_of: CL:1000398 ! endothelial cell of hepatic sinusoid intersection_of: RO:0002220 UBERON:0001279 ! adjacent to portal triad relationship: RO:0002220 UBERON:0001279 ! adjacent to portal triad property_value: terms:contributor https://orcid.org/0000-0003-2034-601X property_value: terms:date "2020-09-09T13:56:47Z" xsd:dateTime [Term] id: CL:0019022 name: endothelial cell of pericentral hepatic sinusoid def: "An endothelial cell found in the centrilobular region hepatic sinusoid, near the central vein. The fenestrae of these cells are smaller but more numerous compared with those of endothelial cells near the periportal region of the hepatic sinusoid." [PMID:27423426] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "central venous hepatic sinusoidal endothelial cell" EXACT [PMID:30348985] synonym: "pericentral LSEC" EXACT [PMID:28287163] xref: EFO:0010706 is_a: CL:1000398 ! endothelial cell of hepatic sinusoid intersection_of: CL:1000398 ! endothelial cell of hepatic sinusoid intersection_of: RO:0002220 UBERON:0006841 ! adjacent to central vein of liver relationship: RO:0002220 UBERON:0006841 ! adjacent to central vein of liver property_value: terms:contributor https://orcid.org/0000-0003-2034-601X property_value: terms:date "2020-09-10T12:38:29Z" xsd:dateTime [Term] id: CL:0019026 name: periportal region hepatocyte def: "Any hepatocyte that is part of the liver lobule periportal region. These cells are primarily involved in oxidative energy metabolism." [PMID:29763190] subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "periportal hepatocyte" EXACT [PMID:29763190] is_a: CL:0000182 ! hepatocyte intersection_of: CL:0000182 ! hepatocyte intersection_of: BFO:0000050 UBERON:8400006 ! part of liver lobule periportal region relationship: BFO:0000050 UBERON:8400006 ! part of liver lobule periportal region property_value: RO:0002175 NCBITaxon:9606 property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0019026" xsd:string {name="periportal region hepatocyte on CELLxGENE CellGuide"} property_value: terms:contributor https://orcid.org/0000-0003-2034-601X property_value: terms:date "2020-10-12T10:29:31Z" xsd:dateTime property_value: terms:description "Periportal region hepatocytes, also known as Zone 1 hepatocytes, are specialized epithelial cells located in the periportal region of the liver acinus, near the portal triad, which comprises the portal vein, hepatic artery, and bile duct. These cells form a major part of the liver's cellular architecture and play a pivotal role in detoxification, metabolism, and homeostasis processes in the human body. \nPeriportal hepatocytes differ functionally from hepatocytes in the liver’s midzone (zone 2) and the pericentral zone 3. They are exposed to higher oxygen concentrations than hepatocytes in zones 2 and 3 because they are closer to the portal triads where oxygen-rich blood enters the liver. They therefore catalyze predominantly oxidative energy metabolism. \nPeriportal hepatocytes are responsible for gluconeogenesis, the process by which glucose is synthesized from smaller precursor molecules like lactate, glycerol and glucogenic amino acids, to maintain blood glucose levels, particularly during fasting periods. Additionally, they carry out cholesterol synthesis, fatty acid oxidation, urea synthesis, and the conversion of ammonia to urea, aiding in the detoxification and excretory functions necessary to maintain homeostasis. Periportal hepatocytes are also associated with bile synthesis and secretion, given their proximity to the bile duct. Bile components facilitate the digestion and absorption of dietary lipids and the removal of waste products from the liver. \nBecause of their location near the portal triad periportal hepatocytes are more resistant to ischemic injury than other hepatocytes but are more susceptible to toxic damage due to their higher exposure to drugs and toxins.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1002/hep.1840010413", xref="DOI:10.1038/s41575-019-0134-x", xref="DOI:10.1093/jn/122.suppl_3.843", xref="DOI:10.1159/000468779", xref="DOI:10.1159/000469338"} [Term] id: CL:0019028 name: midzonal region hepatocyte def: "Any hepatocyte that is part of the liver lobule midzonal region. These cells have mixed functionality in comparison with those in the other two regions of the liver lobule." [PMID:29763190] subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "midzonal hepatocyte" EXACT [PMID:29763190] is_a: CL:0000182 ! hepatocyte intersection_of: CL:0000182 ! hepatocyte intersection_of: BFO:0000050 UBERON:8400008 ! part of liver lobule midzonal region relationship: BFO:0000050 UBERON:8400008 ! part of liver lobule midzonal region property_value: RO:0002175 NCBITaxon:9606 property_value: terms:contributor https://orcid.org/0000-0003-2034-601X property_value: terms:date "2020-10-12T10:57:40Z" xsd:dateTime [Term] id: CL:0019029 name: centrilobular region hepatocyte def: "Any hepatocyte that is part of the liver lobule centrilobular region. These cells are the primary location for the biotransformation of drugs." [PMID:29763190] subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "centrilobular hepatocyte" EXACT [PMID:29763190] is_a: CL:0000182 ! hepatocyte intersection_of: CL:0000182 ! hepatocyte intersection_of: BFO:0000050 UBERON:8400007 ! part of liver lobule centrilobular region relationship: BFO:0000050 UBERON:8400007 ! part of liver lobule centrilobular region property_value: RO:0002175 NCBITaxon:9606 property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0019029" xsd:string {name="centrilobular region hepatocyte on CELLxGENE CellGuide"} property_value: terms:contributor https://orcid.org/0000-0003-2034-601X property_value: terms:date "2020-10-12T11:03:51Z" xsd:dateTime property_value: terms:description "Centrilobular region hepatocytes, also referred to as perivenous or pericentral hepatocytes, are specialized cells that constitute the largest component of the liver. These cells are strategically arranged around the central vein of a liver lobule, forming the zone 3 region. This unique location is critically significant for their distinctive functional capabilities, making them different from periportal hepatocytes of zone 1 and midzonal hepatocytes of zone 2.\nOne of the primary functions of centrilobular region hepatocytes is linked to the body’s metabolic detoxification processes. These cells are predominantly involved in xenobiotic biotransformation, assisting with the metabolism and excretion of foreign substances, such as drugs or harmful toxins. This role is facilitated by their ability to express high levels of Cytochrome P450 enzymes, which are pivotal in phase I detoxification reactions. Additionally, centrilobular region hepatocytes also play a crucial role in bile acid synthesis and the biotransformation of endogenous compounds such as steroids, fatty acids, and bilirubin.\nBeing situated in zone 3, centrilobular hepatocytes are more susceptible to hypoxic injury than other hepatocytes due to the lower oxygen supply. Furthermore, due to their central role in detoxification, they are particularly prone to drug-induced hepatic damage.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:/10.3389/fphys.2021.732929/full", xref="DOI:10.1002/hep.510310201", xref="DOI:10.1007/s10620-006-3174-3", xref="DOI:10.1038/s41575-019-0134-x", xref="DOI:10.1042/bj3290017"} [Term] id: CL:0019031 name: intestine goblet cell def: "Goblet cells reside throughout the length of the small and large intestine and are responsible for the production and maintenance of the protective mucus blanket by synthesizing and secreting high-molecular-weight glycoproteins known as mucins. Human intestinal goblet cells secrete the MUC2 mucin, as well as a number of typical mucus components: CLCA1, FCGBP, AGR2, ZG16, and TFF3." [PMID:1996606, PMID:24942678, PMID:33484640] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "intestinal goblet cell" EXACT [PMID:1996606] is_a: CL:0000160 ! goblet cell is_a: CL:0002563 ! intestinal epithelial cell intersection_of: CL:0000160 ! goblet cell intersection_of: BFO:0000050 UBERON:0001277 ! part of intestinal epithelium relationship: RO:0002202 CL:4047017 ! develops from transit amplifying cell of gut property_value: terms:contributor https://orcid.org/0000-0003-2034-601X property_value: terms:date "2020-10-14T14:59:07Z" xsd:dateTime [Term] id: CL:0019032 name: intestinal tuft cell def: "A tuft cell that is part of the intestinal epithelium, characterized by a distinctive apical tuft and lateral cytospinules connecting to neighbouring cells. This cell senses luminal stimuli via taste receptors and succinate signalling, initiating type 2 immune responses through the secretion of interleukin-25 while modulating epithelial regeneration through prostaglandin synthesis. It expresses key molecular markers such as doublecortin-like kinase 1 (DCLK1) in mice (Hendel et al., 2022), and KIT proto-oncogene in humans (Huang et al., 2024). Developed from intestinal crypt stem cells, this cell requires transcription factor POU2F3 for its development." [PMID:22527717, PMID:29714721, PMID:35237268, PMID:39358509] subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "intestinal brush cell" EXACT [PMID:22527717] is_a: CL:0002204 ! tuft cell is_a: CL:0002563 ! intestinal epithelial cell intersection_of: CL:0002204 ! tuft cell intersection_of: BFO:0000050 UBERON:0001277 ! part of intestinal epithelium relationship: RO:0002202 CL:0002250 ! develops from intestinal crypt stem cell property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/2d-ftu/large-intestine-crypt-lieberkuhn/v1.2/assets/2d-ftu-large-intestine-crypt-lieberkuhn.png" xsd:string {terms:licence="http://creativecommons.org/licenses/by/4.0/", xref="doi:10.48539/HBM294.HJJZ.279"} property_value: RO:0002175 NCBITaxon:9606 property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0019032" xsd:string {name="intestinal tuft cell on CELLxGENE CellGuide"} property_value: terms:contributor https://orcid.org/0000-0003-2034-601X property_value: terms:date "2020-10-15T12:47:46Z" xsd:dateTime property_value: terms:description "Intestinal tuft cells, also known as brush cells, are specialized epithelial cells found in the lining of the intestines. Their name stems from their distinctive morphology, characterized by a thick ‘tuft’, or brush-like, peak of long, tapering microvilli which project into the intestinal lumen. These cells impart a structural characteristic to the epithelium of the intestine, aiding in its function and interaction with the surrounding environment. Their abundance among the gastrointestinal tract varies but they are most commonly found in the small intestine.\nThe primary function of intestinal tuft cells is to act as chemosensory sentinels, assisting in monitoring and responding to luminal factors. They possess a highly potent sensing mechanism, facilitated by a diverse set of receptors, such as the bitter taste receptor family and succinate receptor, and a complex signaling apparatus. These sensory capabilities enable them to initiate crucial immune responses to a variety of physiological stimuli, including parasites and bacteria. Evidence suggests that tuft cells perform a critical role in maintaining gut homeostasis and in initiating type 2 immunity against parasite infection.\nMoreover, intestinal tuft cells are also involved in regulating intestinal epithelial cell homeostasis and contributing to the regeneration and repair of epithelial tissue following damage. They produce several growth factors and cytokines which play essential roles in these processes. Despite being one of the least common cell types in the gut, the role of tuft cells in sensing, immunity and tissue regulation underlines their importance in maintaining gastrointestinal health.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1038/nature24489", xref="DOI:10.1371/journal.ppat.1010318", xref="DOI:10.3389/fimmu.2022.822867", xref="DOI:10.4049/jimmunol.1801069"} [Term] id: CL:0020000 name: gut mesenchymal lymphoid tissue organizer cell def: "A mesenchymal stromal cell found in the gut during development, and interacts with lymphoid tissue inducer (LTi) cells to drive secondary lymphoid organ formation (Prados et al., 2021). It expresses LTβR, PDGFRα, and VCAM, and upon activation secretes chemokines(e.g. CXCL13) and cytokines to organise lymphoid tissue architecture and recruit immune cells in both mice and humans (Denton el al., 2019; Elmentaite et al., 2021). As a multipotent progenitor, an mLTo cell differentiates into adult stromal subsets, including fibroblastic reticular cells (FRCs) (Prados et al., 2021), and its descendants persist in the adult gut-associated lymphoid tissues to maintain immune homeostasis(Denton el al., 2019; Lütge et al., 2021)." [PMID:31324739, PMID:33707780, PMID:34046914, PMID:34497389] subset: human_subset subset: mouse_subset synonym: "gut mLTo cell" RELATED OMO:0003000 [PMID:31201308] is_a: CL:0000134 ! mesenchymal stem cell is_a: CL:0000499 ! stromal cell is_a: CL:0011026 ! progenitor cell property_value: terms:contributor "https://orcid.org/0009-0000-8480-9277" xsd:string property_value: terms:date "2025-01-27T00:00:00Z" xsd:dateTime [Term] id: CL:0020001 name: V1delta gamma-delta T cell def: "A mature gamma-delta T Cell with T cell receptors consisting of the Vδ1 segment paired with various V gamma chains. This cell is enriched in the gut, skin (Davey et al., 2018) and the female reproductive tract (Wu et al., 2022). It exhibits potent cytotoxic capabilities through perforin/granzyme and death receptor pathways." [PMID:25991474, PMID:29680462, PMID:35637401, PMID:37989744] subset: human_subset subset: mouse_subset synonym: "Vδ1+ Gamma-Delta T cell" RELATED OMO:0003000 [] synonym: "Vδ1+ γδ T Cell" RELATED OMO:0003000 [PMID:24895997] is_a: CL:0000800 ! mature gamma-delta T cell property_value: terms:contributor https://orcid.org/0009-0000-8480-9277 property_value: terms:date "2025-09-29T10:40:48Z" xsd:dateTime [Term] id: CL:0020002 name: mucosal-associated invariant T cell, human def: "A mucosal-associated invariant T (MAIT) cell found in various tissues including human blood, liver, gut, and lung, characterised by a semi-invariant T cell receptor (TCR) comprising TRAV1-2 (Vα7.2) predominantly paired with TRAJ33, and high expression of CD161. Upon activation, MAIT cells produce inflammatory cytokines, including IFN-γ, TNF-α, and IL-17." [PMID:26382249, PMID:33352411, PMID:35641678, PMID:40781543] subset: human_subset synonym: "MAIT, human" RELATED OMO:0003000 [PMID:40781543] synonym: "mucosal-associated invariant T lymphocyte, human" EXACT [] synonym: "mucosal-associated invariant T-cell, human" EXACT [] synonym: "mucosal-associated invariant T-lymphocyte, human" EXACT [] is_a: CL:0000940 ! mucosal-associated invariant T cell intersection_of: CL:0000940 ! mucosal-associated invariant T cell intersection_of: CL:4030046 PR:Q12918 ! lacks_plasma_membrane_part killer cell lectin-like receptor subfamily B member 1 (human) intersection_of: RO:0002104 PR:A0A0B4J238 ! has plasma membrane part T cell receptor alpha variable 1-2 (human) intersection_of: RO:0002162 NCBITaxon:9606 ! in taxon Homo sapiens relationship: CL:4030046 PR:Q12918 ! lacks_plasma_membrane_part killer cell lectin-like receptor subfamily B member 1 (human) relationship: RO:0002104 PR:A0A0B4J238 ! has plasma membrane part T cell receptor alpha variable 1-2 (human) property_value: terms:contributor https://orcid.org/0000-0001-5742-4697 property_value: terms:contributor https://orcid.org/0009-0000-8480-9277 property_value: terms:date "2025-10-07T00:00:00Z" xsd:dateTime [Term] id: CL:0020003 name: internal globus pallidus core projecting neuron def: "A projection neuron that has its soma located in the internal segment of the globus pallidus (GPi) of primates, in the central “core” region. It expresses parvalbumin, is primarily GABAergic, and projects to motor thalamic nuclei including the ventral anterior, ventrolateral, and ventromedial nuclei. In the rodent homolog (entopeduncular nucleus), the core subregion is characterized by concentrated parvalbumin-positive neurons targeting the ventral anterior-ventral lateral thalamic nucleus and receives inputs from the dorsolateral striatum innervated by sensorimotor cortices (Miyamoto & Fukuda, 2022). This neuron corresponds to the sensorimotor output population of the GPi, as demonstrated in human tissue and cross-species comparative studies (Wallace et al., 2017) and by classic tracing in primates (Parent & De Bellefeuille, 1982; Parent et al., 2001)." [PMID:11596046, PMID:28384468, PMID:28949036, PMID:35927027, PMID:7127069] subset: human_subset subset: mouse_subset synonym: "GPi core" RELATED OMO:0003000 [PMID:7127069] is_a: BFO:0000002 is_a: CL:0000617 ! GABAergic neuron is_a: CL:0012001 ! neuron of the forebrain relationship: RO:0002100 UBERON:0002477 ! has soma location medial globus pallidus relationship: RO:0002292 PR:000013502 ! expresses parvalbumin alpha property_value: foaf:depiction http://purl.obolibrary.org/obo/cl/images/GPi_core_shell_myamoto.jpg {dc:license="https://creativecommons.org/licenses/by-nc-nd/4.0/", xref="PMID:35927027"} property_value: terms:contributor https://orcid.org/0000-0002-5507-2103 property_value: terms:date "2025-01-31T00:00:00Z" xsd:dateTime [Term] id: CL:0020004 name: internal globus pallidus shell projection neuron def: "A projection neuron that has its soma located in the internal segment of the globus pallidus (GPi), in the peripheral 'shell' region. In mice and primates, it expresses somatostatin and shows dual expression of GABAergic and glutamatergic markers, enabling co-release of GABA and glutamate (Wallace et al., 2017). It projects primarily to the lateral habenula (Parent & De Bellefeuille, 1982; Wallace et al., 2017), forming the limbic/aversive output stream of the GPi." [doi:10.1101/2022.03.16.484460, PMID:11596046, PMID:28384468, PMID:30755721, PMID:33787995, PMID:7127069] subset: human_subset subset: mouse_subset synonym: "GPi shell" RELATED OMO:0003000 [PMID:28384468] is_a: BFO:0000002 is_a: CL:0000617 ! GABAergic neuron is_a: CL:0012001 ! neuron of the forebrain relationship: RO:0002100 UBERON:0002477 ! has soma location medial globus pallidus relationship: RO:0002292 PR:000015665 ! expresses somatostatin property_value: terms:contributor https://orcid.org/0000-0002-5507-2103 creation_date: 2025-09-30T14:21:41Z [Term] id: CL:0020005 name: spiral ligament fibrocyte def: "An otic fibrocyte that is part of the spiral ligament. This cell is crucial in maintaining the endocochlear potential, regulating blood flow, participating in immune responses by secreting chemokines including MCP-1 and MIP-2, and producing extracellular matrix proteins such as collagen and cochlin." [PMID:10675641, PMID:33193034] subset: human_subset subset: mouse_subset synonym: "SLF" RELATED OMO:0003000 [PMID:33193034] is_a: CL:0002665 ! otic fibrocyte relationship: BFO:0000050 UBERON:0006725 ! part of spiral ligament property_value: terms:contributor https://orcid.org/0009-0000-8480-9277 creation_date: 2025-10-27T15:56:54Z [Term] id: CL:0020006 name: OB-Dopa-GABA def: "A transcriptomically defined GABAergic neuron coexpressing dopamine located in the olfactory bulb and part of the striatum." [PMID:35322231] subset: human_subset subset: mouse_subset is_a: CL:0000617 ! GABAergic neuron is_a: CL:0000700 ! dopaminergic neuron is_a: CL:0002613 ! striatum neuron property_value: terms:contributor "https://orcid.org/0000-0002-5507-2103" xsd:string [Term] id: CL:0020007 name: dorso-striatal cholinergic-GABAergic neuron def: "A transcriptomically defined GABAergic neuron in the dorsal striatum. In mice and primates, it is defined by the coexpression of choline acetyltransferase (ChAT) together with the GABAergic markers glutamate decarboxylase 65 (GAD65/Gad2) and vesicular GABA transporter (VGAT/Slc32a1) (Lozovaya et al., 2018)." [PMID:10934256, PMID:19855026, PMID:29651049, PMID:37464873] subset: human_subset subset: mouse_subset is_a: CL:0002613 ! striatum neuron is_a: CL:0008061 ! GABA-Chol neuron is_a: CL:0011005 ! GABAergic interneuron property_value: IAO:0000028 "STRd Cholinergic GABA" xsd:string property_value: terms:contributor https://orcid.org/0000-0002-5507-2103 property_value: terms:date "2025-10-23T08:36:33Z" xsd:dateTime [Term] id: CL:0020008 name: striatal cholinergic-GABAergic neuron def: "A large aspiny interneuron of the striatum that serves as the principal intrinsic source of acetylcholine while simultaneously releasing GABA. It is defined by coexpression of cholinergic markers (ChAT and VAChT/Slc18a3) and GABAergic markers (GAD65/Gad2 and VGAT/Slc32a1) (Lozovaya et al., 2018). This MGE-derived neuron maintains Lhx6 expression associated with dual-transmitter identity (Fragkouli et al., 2009; Marin et al., 2000). Morphologically, it possesses a large soma (20–50 μm diameter), 2–4 thick aspiny dendrites extending radially ~1 mm, and locally ramified axons with hundreds of thousands of varicosities (Wilson et al., 1990; Lim et al., 2014)." [PMID:10377365, PMID:10934256, PMID:21925242, PMID:2329464, PMID:25374536, PMID:25876458, PMID:29651049, PMID:37905876] subset: human_subset subset: mouse_subset synonym: "CGIN" RELATED OMO:0003000 [PMID:29651049] is_a: CL:0002613 ! striatum neuron is_a: CL:0008061 ! GABA-Chol neuron is_a: CL:0011005 ! GABAergic interneuron property_value: IAO:0000028 "STR Cholinergic GABA" xsd:string property_value: terms:contributor https://orcid.org/0000-0002-5507-2103 property_value: terms:description "Although they constitute only 1–3% of all striatal neurons, these interneurons form a major modulatory hub, integrating cortical, thalamic, and dopaminergic inputs and shaping striatal output dynamics (Gonzales & Smith, 2015; Wegman et al., 2024). Electrophysiologically, the neuron exhibits tonic autonomous firing at 3–10 Hz, broad action potentials, and a prominent hyperpolarization-activated inward current (Ih) (Bennett & Wilson, 1999; Goldberg & Reynolds, 2011). Functionally, it modulates corticostriatal and thalamostriatal synaptic transmission, dopamine release, and spiny projection neuron excitability through co-transmission of acetylcholine and GABA (Lozovaya et al., 2018; Wegman et al., 2024). This dual inhibitory and modulatory signaling underlies context-dependent control of synaptic plasticity, action selection, and reinforcement learning (Gonzales & Smith, 2015; Lozovaya et al., 2018)." xsd:string {xref="PMID:10377365", xref="PMID:25876458", xref="PMID:29651049", xref="PMID:37905876"} [Term] id: CL:0020009 name: prototypic neuron def: "A GABAergic neuron located in the external globus pallidus (GPe) that constitutes approximately two-thirds of all GPe neurons (Mallet et al., 2012, Dodson et al., 2015). Derived from the medial ganglionic eminence, this cell selectively expresses Nkx2-1, with roughly two-thirds co-expressing parvalbumin (PV) and one-third lacking it in mice (Mallet et al., 2012; Dodson et al., 2015)." [doi:10.1101/2022.03.16.484460, PMID:22726837, PMID:25843402, PMID:25926446, PMID:27194328, PMID:37336974] subset: human_subset subset: mouse_subset is_a: BFO:0000002 is_a: CL:0000617 ! GABAergic neuron is_a: CL:0012001 ! neuron of the forebrain relationship: RO:0002100 UBERON:0002476 ! has soma location lateral globus pallidus relationship: RO:0002202 UBERON:0004024 ! develops from medial ganglionic eminence relationship: RO:0002292 PR:000011241 ! expresses homeobox protein Nkx-2.1 property_value: IAO:0000028 "GPe SOX6-CTXND1 GABA" xsd:string property_value: terms:contributor https://orcid.org/0000-0002-5507-2103 property_value: terms:description "The prototypic neuron projects to downstream basal ganglia nuclei, including the subthalamic nucleus (STN), internal globus pallidus, and substantia nigra pars reticulata (SNr), with some neurons also emitting ascending collaterals that modestly innervate the striatum (Mallet et al., 2012, Abdi et al., 2015). It exhibits longer local axon collaterals with more boutons compared to arkypallidal neurons, supporting extensive local interconnectivity within the GPe (Mallet et al., 2012). The prototypic neuron plays a fundamental role in the indirect pathway of the basal ganglia, coordinating activity across basal ganglia nuclei through its widespread projections (Mallet et al., 2012, Courtney et al., 2023). Decreases in firing during movement are consistent with disinhibiting the STN and output nuclei, thereby facilitating the expression of desired motor patterns (Dodson et al., 2015, Courtney et al., 2023)." xsd:string {xref="PMID:22726837", xref="PMID:25843402", xref="PMID:25926446", xref="PMID:37336974"} creation_date: 2025-10-17T09:12:54Z [Term] id: CL:0020010 name: arkypallidal neuron def: "A GABAergic projection neuron located in the external segment of the globus pallidus (GPe) and defined by its exclusive projection to the dorsal striatum rather than to the subthalamic nucleus or basal ganglia output nuclei. In rodents and primates, it is characterized molecularly by expression of FOXP2, MEIS2, and NPAS1, and lacks expression of canonical pallidal markers NKX2-1 and LHX6 (Dodson et al., 2015; Abdi et al., 2015; Courtney et al., 2023). This neuron is GABAergic (GAD1/2⁺, SLC32A1/VGAT⁺) and typically PV⁻, forming the transcriptionally and developmentally LGE-derived subclass of GPe neurons (Dodson et al., 2015; Mallet et al., 2012)." [PMID:22726837, PMID:25843402, PMID:25926446, PMID:27194328, PMID:37336974] subset: human_subset subset: mouse_subset is_a: CL:0000617 ! GABAergic neuron is_a: CL:0012001 ! neuron of the forebrain is_a: CL:4023035 ! lateral ganglionic eminence derived neuron relationship: RO:0002100 UBERON:0002476 ! has soma location lateral globus pallidus property_value: IAO:0000028 "GPe MEIS2-SOX6 GABA" xsd:string property_value: terms:contributor https://orcid.org/0000-0002-5507-2103 creation_date: 2025-10-16T10:21:41Z [Term] id: CL:0020011 name: hair follicle associated fibroblast def: "A specialized dermal fibroblast within the hair follicle mesenchymal compartment that participates in epithelial-mesenchymal signaling to regulate hair morphogenesis, cycling, and homeostasis through production of inductive signals and extracellular matrix maintenance." [PMID:20022473, PMID:34297930] subset: human_subset subset: mouse_subset is_a: CL:0002559 ! hair follicle cell is_a: CL:0002620 {is_inferred="true"} ! skin fibroblast intersection_of: CL:0002620 ! skin fibroblast intersection_of: BFO:0000050 UBERON:0002073 ! part of hair follicle property_value: terms:contributor https://orcid.org/0009-0000-8480-9277 property_value: terms:date "2025-11-04T15:29:55Z" xsd:dateTime [Term] id: CL:0020012 name: hair follicle isthmus-associated fibroblast def: "A fibroblast that is part of the hair follicle isthmus (mid-hair shaft). In humans, this cell expresses CRABP1/COCH/RSPO4 and tendon-associated genes (MKX, TNMD)." [PMID:40993240] subset: human_subset subset: mouse_subset is_a: CL:0020011 ! hair follicle associated fibroblast intersection_of: CL:0000057 ! fibroblast intersection_of: BFO:0000050 UBERON:0006005 ! part of hair follicle isthmus relationship: BFO:0000050 UBERON:0006005 ! part of hair follicle isthmus property_value: terms:contributor https://orcid.org/0009-0000-8480-9277 [Term] id: CL:0020013 name: dermal sheath fibroblast def: "A fibroblast forming the connective tissue sheath that encloses the hair follicle epithelium from the level of the bulge downward to the hair bulb. This cell expresses characteristic markers, including DPEP1 in humans and COL11A1 and ACTA2 (alpha-smooth muscle actin) in mice and humans. Dermal sheath fibroblast possesses contractile properties mediated by calcium-calmodulin-myosin light chain kinase signalling, generating centripetal force during hair follicle catagen that relocates the dermal papilla to the stem cell niche." [PMID:31857493, PMID:35069694] subset: human_subset subset: mouse_subset synonym: "DS fibroblast" RELATED [PMID:34297930] is_a: CL:0020011 ! hair follicle associated fibroblast relationship: RO:0002215 GO:0006936 ! capable of muscle contraction relationship: RO:0002292 PR:000003675 ! expresses actin, aortic smooth muscle relationship: RO:0002292 PR:000005694 ! expresses collagen alpha-1(XI) chain relationship: RO:0002292 PR:P16444 ! expresses dipeptidase 1 (human) property_value: terms:contributor https://orcid.org/0009-0000-8480-9277 [Term] id: CL:0020014 name: intrinsically photosensitive retinal ganglion cell def: "A retinal ganglion cell that is intrinsically photosensitive, functioning as a non-image-forming photoreceptor, distinguished from rod and cone photoreceptors by the expression of the photopigment melanopsin in mice and humans (Hattar et al., 2002; Tri Hoang Do & Yau, 2015). Located primarily in the ganglion cell layer with some displaced somata in the inner nuclear layer, this neuron depolarises directly in response to environmental irradiance (Tri Hoang Do & Yau, 2015). It projects via the retinohypothalamic tract to central targets, including the suprachiasmatic nucleus (SCN) for circadian photoentrainment and the olivary pretectal nucleus (OPN) for the pupillary light reflex." [PMID:11834834, PMID:20959623, Wikipedia:Intrinsically_photosensitive_retinal_ganglion_cell] subset: human_subset subset: mouse_subset synonym: "ipRGC" RELATED OMO:0003000 [PMID:20959623] synonym: "photosensitive ganglion cell" BROAD [http://www.wikidata.org/entity/Q934475] is_a: CL:0000210 ! photoreceptor cell is_a: CL:0000740 ! retinal ganglion cell relationship: RO:0002292 PR:000001243 ! expresses melanopsin property_value: dc:creator "GitHub Copilot" xsd:string property_value: terms:contributor https://orcid.org/0000-0003-2473-2313 property_value: terms:contributor https://orcid.org/0009-0000-8480-9277 [Term] id: CL:0020015 name: transitional principal-intercalated cell of kidney collecting duct def: "A transitional cell located in the renal collecting duct that co-expresses markers of both principal cell (PC) and intercalated cell (IC). This hybrid cell is enriched in Chronic Kidney Disease (CKD)." [PMID:33893305, PMID:37468583] subset: human_subset subset: mouse_subset synonym: "hybrid principal-intercalated cell" BROAD [PMID:37468583] synonym: "tPC-IC cell" RELATED OMO:0003000 [PMID:37468583] is_a: CL:1000454 ! kidney collecting duct epithelial cell property_value: dc:creator "GitHub Copilot" xsd:string property_value: terms:contributor https://orcid.org/0000-0002-2999-0103 property_value: terms:contributor https://orcid.org/0009-0000-8480-9277 [Term] id: CL:0020016 name: osteochondral skeletal stem cell def: "A tissue-specific stem cell with long-term self-renewal capacity that is restricted to generating bone, cartilage, and stromal cell lineages. This cell is primarily located in the growth plate (resting zone), periosteum, and subchondral bone regions, and is marked by high clonogenicity and robust multipotent differentiation potential in both osteogenic and chondrogenic lineages. Distinctively, ocSSC lacks adipogenic capacity, distinguishing it from other mesenchymal stem cell populations." [doi:10.1101/2023.12.07.570646, PMID:34280086] subset: human_subset subset: mouse_subset synonym: "ocSSC" RELATED OMO:0003000 [PMID:34280086] is_a: CL:0000034 ! stem cell relationship: BFO:0000050 UBERON:0001434 ! part of skeletal system relationship: RO:0002215 GO:0001649 ! capable of osteoblast differentiation relationship: RO:0002215 GO:0051216 ! capable of cartilage development property_value: terms:contributor https://orcid.org/0009-0000-8480-9277 property_value: terms:creator "GitHub Copilot" xsd:string property_value: terms:date "2025-11-27T00:00:00Z" xsd:dateTime [Term] id: CL:0020017 name: M0 macrophage def: "A macrophage that has not yet undergone polarization into a specific macrophage subtype. These cells are non-activated and have the potential to differentiate into inflammatory (M1) or alternatively activated (M2) macrophage subtypes in response to appropriate stimuli." [DOI:10.1186/s12885-022-09872-y, PMID:30861466] subset: human_subset subset: mouse_subset synonym: "naive macrophage" EXACT [] synonym: "non-activated macrophage" EXACT [] synonym: "resting-state macrophages" EXACT [DOI:10.1186/s12885-022-09872-y] is_a: CL:0000235 ! macrophage property_value: dc:creator "GitHub Copilot" xsd:string [Term] id: CL:0020018 name: proliferative fibrochondrocyte def: "A fibrochondrocyte located in fibrocartilage that exhibits active proliferation capacity and is in S phase of the cell cycle. It functions as a progenitor cell positioned at the root of developmental trajectories alongside fibrochondrocyte progenitors (FCP), with the capacity to diverge toward one of two developmental fates: (1) fibrochondrocytes and prehypertrophic chondrocytes, or (2) regulatory chondrocytes and prehypertrophic chondrocytes. It is characterised by co-expression of COL1A1, the growth factors FGF7 and CTGF, and the cell-cycle genes STMN1, KIAA0101, and MCM3 in humans. During early progenitor differentiation, FGF7 and COL1A1 expression increases and then declines as the cell commits to terminal fates." [PMID:31871141, PMID:39759119] comment: Lineage relationships are inferred from single-cell RNA-seq trajectories and validated through experimental approaches, including FACS isolation, functional differentiation assays, and in vivo developmental gene expression analysis. {xref="PMID:31871141"} subset: human_subset subset: mouse_subset synonym: "ProFC" RELATED OMO:0003000 [PMID:31871141] is_a: CL:4072104 ! fibrochondrocyte relationship: RO:0000056 GO:0022402 ! participates in cell cycle process relationship: RO:0002292 PR:000007498 ! expresses fibroblast growth factor 7 property_value: terms:contributor https://orcid.org/0009-0000-8480-9277 property_value: terms:creator "GitHub Copilot" xsd:string property_value: terms:date "2025-11-27T12:48:39Z" xsd:dateTime [Term] id: CL:0020019 name: regulatory chondrocyte def: "A chondrocyte located mainly in the superficial zone of articular cartilage. In healthy human cartilage, regulatory chondrocytes are characterized by expression of EIF5A, PGK1, ANXA1, and TUBA1A. During osteoarthritis, a distinct subpopulation expands, marked by high expression of CHI3L1, CHI3L2, CRTAC1, and AEBP1, with enrichment for signaling pathway regulation (including Toll-like receptor, mTOR, and TGF-beta signaling) and antigen-processing gene expression, with a small proportion expressing MHC class II genes, suggesting potential immune cell-like regulatory functions during osteoarthritis progression." [PMID:30026257, PMID:34045450, PMID:37660146] subset: human_subset subset: mouse_subset synonym: "RegC" RELATED [PMID:37660146] is_a: CL:0000138 ! chondrocyte property_value: dc:creator "GitHub Copilot" xsd:string property_value: terms:contributor https://orcid.org/0009-0000-8480-9277 [Term] id: CL:0020020 name: homeostatic chondrocyte def: "A chondrocyte identified in both healthy and osteoarthritic human articular cartilage, and in intervertebral disc tissue. In healthy articular cartilage, a homeostatic chondrocyte is characterised by the expression of TXNIP, IFITM3, GDF15, and TIMP1 (Wang et al., 2021), among other extracellular matrix and regulatory molecules. This cell maintains cartilage integrity by producing key ECM components and supporting baseline tissue homeostasis. In OA cartilage, this cell is enriched for genes related to cellular homeostasis modulation, including regulation of the cell cycle, development, and RNA metabolism (Ji et al., 2018)." [PMID:30026257, PMID:34045450, PMID:34400611, PMID:37660146] subset: human_subset subset: mouse_subset synonym: "HomC" RELATED OMO:0003000 [PMID:37660146] is_a: CL:0000138 ! chondrocyte relationship: RO:0002215 GO:0070278 ! capable of extracellular matrix constituent secretion relationship: RO:0002215 GO:1990079 ! capable of cartilage homeostasis property_value: dc:creator "GitHub Copilot" xsd:string property_value: terms:contributor https://orcid.org/0009-0000-8480-9277 [Term] id: CL:0020021 name: fibrochondrocyte progenitor cell def: "A mesenchymal progenitor cell located in fibrocartilaginous tissues, along the fibrochondrocytic differentiation pathway that co-expresses both fibrochondrocyte markers (COL1A1, COL3A1) and mesenchymal stem cell markers (MCAM/CD146, MYLK) in humans. This cell serves as a progenitor for mature fibrochondrocytes and other meniscal cell types, with differentiation regulated by TGF-β signaling, focal adhesion, and extracellular matrix-receptor interaction pathways." [PMID:31871141, PMID:36338137] comment: A fibrochondrocyte progenitor cell demonstrates colony-forming capacity and multi-lineage differentiation potential toward osteogenic and adipogenic lineages. {xref="PMID:31871141"} subset: human_subset subset: mouse_subset synonym: "FCP" RELATED OMO:0003000 [PMID:31871141] is_a: CL:0002320 ! connective tissue cell is_a: CL:0008019 ! mesenchymal cell is_a: CL:0011026 ! progenitor cell relationship: BFO:0000050 UBERON:0001995 ! part of fibrocartilage property_value: terms:contributor https://orcid.org/0009-0000-8480-9277 property_value: terms:creator "GitHub Copilot" xsd:string [Term] id: CL:0020022 name: prehypertrophic chondrocyte def: "A post-proliferative chondrocyte in the prehypertrophic zone of the cartilage tissue, located between the proliferative and hypertrophic zones. This cell is characterised by increased cell volume and expression of Indian Hedgehog (Ihh), PTH1R, and Runx2/3 in both humans and mice (Hallett et al., 2021). It coordinates the PTHrP-Ihh feedback loop that regulates chondrocyte differentiation and functions as a signalling hub for communication between proliferative chondrocytes, hypertrophic chondrocytes, and periosteal osteoblasts (Hallett et al., 2021)." [PMID:29985449, PMID:31871141, PMID:34137454] subset: human_subset subset: mouse_subset synonym: "preHTC" RELATED OMO:0003000 [] is_a: CL:0000138 ! chondrocyte relationship: RO:0002207 CL:0000743 ! directly develops from hypertrophic chondrocyte property_value: terms:contributor https://orcid.org/0009-0000-8480-9277 [Term] id: CL:0020023 name: effector chondrocyte def: "A metabolically highly active chondrocyte that is identified in the cartilaginous tissues, including articular cartilage and intervertebral disc cartilage. In the human articular cartilage, this cell is marked by genes such as CYTL1, FRZB, CLEC3A, and S100B (Ji et al., 2018; Raut et al.,2025). This cell demonstrates strong metabolic activity and is implicated in extracellular matrix regulation and adaptive responses (Ji et al., 2018; Gan et al., 2021; Raut et al.,2025)." [PMID:21652695, PMID:30026257, PMID:34400611, PMID:38868774, PMID:40753276] subset: human_subset subset: mouse_subset synonym: "EC" RELATED OMO:0003000 [PMID:38868774] is_a: CL:0000138 ! chondrocyte property_value: terms:contributor https://orcid.org/0009-0000-8480-9277 property_value: terms:creator "GitHub Copilot" xsd:string creation_date: 2025-12-01T11:46:23Z [Term] id: CL:0020024 name: alpha retinal ganglion cell OFF-sustained (Mmus) def: "A mouse retinal ganglion cell type defined by a large soma and a wide, monostratified dendritic arbor that stratifies just distal to the outer ChAT band of the inner plexiform layer (Krieger et al., 2017). It corresponds to the G5 physiological type (Baden et al., 2016; Goetz et al., 2022) and the C42 transcriptomic cluster (Tran et al., 2019), and is considered the evolutionary ortholog of the primate OFF midget RGC (Hahn et al., 2023). The cell projects a thick, fast-conducting axon to the dorsal lateral geniculate nucleus and superior colliculus. It shows a sustained increase in firing to light decrements with a slow decay time constant of roughly 250 ms and a large receptive field center with weak surround antagonism (Krieger et al., 2017). Its molecular profile includes expression of Spp1 and Neurofilament (Smi32) together with Brn3a (Pou4f1) and Brn3b (Pou4f2), absence of Brn3c (Pou4f3) and Calbindin (Calb1), and strong enrichment of Fes (Krieger et al., 2017; Tran et al., 2019)." [PMID:26735013, PMID:28753612, PMID:35830791, PMID:37066415] comment: The G-type nomenclature used here refers specifically to the functional classification of mouse retinal ganglion cells introduced by Baden and colleagues, and is distinct from earlier G-based schemes used for rabbit or other species. Readers should be aware that the same letter–number labels (e.g., "G1", "G2") have been applied in different historical contexts to different animals and criteria (functional vs. morphological), so cross-species or cross-era comparisons of "G" names should not be assumed equivalent without explicit mapping in the primary literature. {xref="PMID:26735013"} subset: mouse_subset synonym: "alpha retinal ganglion cell OFF-s" RELATED OMO:0003000 [PMID:28753612] synonym: "C42" EXACT [PMID:31784286] synonym: "G5" EXACT [PMID:26735013] is_a: CL:0004117 ! retinal ganglion cell A is_a: CL:4023033 ! OFF retinal ganglion cell property_value: RO:0002175 NCBITaxon:10090 property_value: terms:contributor https://orcid.org/0000-0002-5507-2103 property_value: terms:creator "GitHub Copilot" xsd:string [Term] id: CL:0020025 name: alpha retinal ganglion cell ON-sustained (Mmus) def: "A retinal ganglion cell type that has a large soma and a wide, monostratified dendritic arbor that stratifies in the inner sublamina of the inner plexiform layer, with dendrites located just proximal to the inner ChAT band (Krieger et al., 2017). It shows a sustained increase in firing rate to ON stimuli (Krieger et al., 2017). It corresponds to the G24 functional type (Baden et al., 2016; Goetz et al., 2022), the C43 transcriptomic cluster (Tran et al., 2019), and is considered the mouse ortholog of the primate ON midget retinal ganglion cell (Hahn et al., 2023). It is molecularly defined by expression of Spp1, Smi32, Brn3b, Calbindin, and Tbr2 (Krieger et al., 2017; Tran et al., 2019)." [PMID:26735013, PMID:28753612, PMID:31784286, PMID:35830791, PMID:38092908] comment: The G-type nomenclature used here refers specifically to the functional classification of mouse retinal ganglion cells introduced by Baden and colleagues, and is distinct from earlier G-based schemes used for rabbit or other species. Readers should be aware that the same letter–number labels (e.g., "G1", "G2") have been applied in different historical contexts to different animals and criteria (functional vs. morphological), so cross-species or cross-era comparisons of "G" names should not be assumed equivalent without explicit mapping in the primary literature. {xref="PMID:26735013"} subset: mouse_subset synonym: "alpha retinal ganglion cell ON-s" RELATED OMO:0003000 [PMID:28753612] synonym: "C43" EXACT [PMID:31784286] synonym: "G24" EXACT [PMID:26735013, PMID:35830791] is_a: CL:0004117 ! retinal ganglion cell A is_a: CL:4023032 ! ON retinal ganglion cell property_value: RO:0002175 NCBITaxon:10090 property_value: terms:contributor "https://orcid.org/0000-0002-5507-2103" xsd:string property_value: terms:creator "GitHub Copilot" xsd:string [Term] id: CL:0020026 name: alpha retinal ganglion cell OFF-transient (Mmus) def: "An alpha retinal ganglion cell subtype found in the mouse retina that responds selectively and transiently to decreases in light intensity. It is characterized by a large soma, a broad dendritic arbor that stratifies within sublamina a of the inner plexiform layer, and rapid OFF-transient firing kinetics that decay even during sustained stimulation (Krieger et al., 2017). Functionally, it corresponds to G8 in the Baden functional classification (Baden et al., 2016; Goetz et al., 2022) and C45 in the Tran transcriptomic atlas (Tran et al., 2019), and it is considered the evolutionary ortholog of the primate OFF Parasol RGC (Hahn et al., 2023). This cell type acts as a detector of rapidly approaching dark objects and contributes to innate defensive responses by encoding looming stimuli (Münch et al., 2009). It exhibits a distinctive molecular signature by its expression of Brn3c (Krieger et al., 2017)." [PMID:26735013, PMID:28753612, PMID:35830791, PMID:37066415] comment: The G-type nomenclature used here refers specifically to the functional classification of mouse retinal ganglion cells introduced by Baden and colleagues, and is distinct from earlier G-based schemes used for rabbit or other species. Readers should be aware that the same letter–number labels (e.g., "G1", "G2") have been applied in different historical contexts to different animals and criteria (functional vs. morphological), so cross-species or cross-era comparisons of "G" names should not be assumed equivalent without explicit mapping in the primary literature. {xref="PMID:26735013"} subset: mouse_subset synonym: "alpha retinal ganglion cell OFF-t" RELATED OMO:0003000 [PMID:28753612] is_a: CL:0004117 ! retinal ganglion cell A is_a: CL:4023033 ! OFF retinal ganglion cell property_value: IAO:0000233 "https://github.com/obophenotype/cell-ontology/issues/3493" xsd:string property_value: terms:contributor https://orcid.org/0000-0002-5507-2103 property_value: terms:creator "GitHub Copilot" xsd:string creation_date: 2025-12-05T11:29:19Z [Term] id: CL:0020027 name: alpha retinal ganglion cell ON-transient (Mmus) def: "An alpha retinal ganglion cell subtype in the mouse retina that responds selectively and transiently to increases in light intensity. It possesses the large soma and expansive dendritic field characteristic of alpha RGCs (Krieger et al., 2017). This cell exhibits a brief, fast-decaying burst of firing at the onset of light increments and contributes to motion detection for luminance increases, forming the ON-branch of the transient magnocellular-like pathway (Krieger et al., 2017; Hahn et al., 2023). Functionally, it corresponds to cluster G19 and aligns transcriptomically with cluster C41 (Krieger et al., 2017; Tran et al., 2019). It is orthologous to the primate ON Parasol RGC (Hahn et al., 2023). Molecularly, it expresses Spp1, Smi32, and Brn3b, but lacks Brn3a, Brn3c, and Calbindin (Krieger et al., 2017)." [PMID:26735013, PMID:28753612, PMID:31784286, PMID:35830791, PMID:37066415] comment: The G-type nomenclature used here refers specifically to the functional classification of mouse retinal ganglion cells introduced by Baden and colleagues, and is distinct from earlier G-based schemes used for rabbit or other species. Readers should be aware that the same letter–number labels (e.g., "G1", "G2") have been applied in different historical contexts to different animals and criteria (functional vs. morphological), so cross-species or cross-era comparisons of "G" names should not be assumed equivalent without explicit mapping in the primary literature. {xref="PMID:26735013"} subset: mouse_subset synonym: "alpha retinal ganglion cell ON-t" RELATED [PMID:28753612] synonym: "C41" EXACT [PMID:31784286] synonym: "G19" EXACT [PMID:26735013, PMID:28753612] is_a: CL:0004117 ! retinal ganglion cell A is_a: CL:4023032 ! ON retinal ganglion cell property_value: RO:0002175 NCBITaxon:10090 property_value: terms:contributor https://orcid.org/0000-0002-5507-2103 property_value: terms:creator "GitHub Copilot" xsd:string property_value: terms:date "2025-12-05T00:00:00Z" xsd:dateTime [Term] id: CL:0700009 name: obsolete kidney collecting duct beta-intercalated cell def: "OBSOLETE. A renal beta-intercalated cell that is part of the cortical collecting duct. The medullary collecting duct does not contain the renal beta-intercalated cell type." [PMID:24051376, PMID:31300091, PMID:32016094] comment: Created with IRI in incorrect ID range synonym: "B-IC" EXACT [PMID:32016094] synonym: "kidney collecting duct intercalated cell type B" EXACT [PMID:31300091] property_value: terms:date "2022-08-26T10:31:29Z" xsd:dateTime is_obsolete: true replaced_by: CL:4030005 [Term] id: CL:1000001 name: retrotrapezoid nucleus neuron def: "Any neuron that has its soma located in some retrotrapezoid nucleus." [FBC:Autogenerated] subset: human_subset subset: mouse_subset is_a: BFO:0000002 is_a: CL:2000029 ! central nervous system neuron intersection_of: CL:0000540 ! neuron intersection_of: RO:0002100 UBERON:0009918 ! has soma location retrotrapezoid nucleus relationship: RO:0002100 UBERON:0009918 ! has soma location retrotrapezoid nucleus [Term] id: CL:1000022 name: mesonephric nephron tubule epithelial cell def: "Any epithelial cell that is part of some mesonephric nephron tubule." [FBC:Autogenerated] subset: cellxgene_subset subset: human_subset subset: mouse_subset is_a: CL:1000449 ! epithelial cell of nephron is_a: CL:1000507 ! kidney tubule cell intersection_of: CL:0000066 ! epithelial cell intersection_of: BFO:0000050 UBERON:0005329 ! part of mesonephric nephron tubule relationship: BFO:0000050 UBERON:0005329 ! part of mesonephric nephron tubule [Term] id: CL:1000042 name: forebrain neuroblast def: "Any neuroblast (sensu Vertebrata) that is part of some forebrain." [FBC:Autogenerated] subset: cellxgene_subset subset: human_subset subset: mouse_subset is_a: CL:0000031 ! neuroblast (sensu Vertebrata) is_a: CL:0002319 ! neural cell intersection_of: CL:0000031 ! neuroblast (sensu Vertebrata) intersection_of: BFO:0000050 UBERON:0001890 ! part of forebrain relationship: BFO:0000050 UBERON:0001890 ! part of forebrain [Term] id: CL:1000050 name: lateral line nerve glial cell def: "Any glial cell that is part of some lateral line nerve." [FBC:Autogenerated] is_a: CL:0000125 ! glial cell intersection_of: CL:0000125 ! glial cell intersection_of: BFO:0000050 UBERON:0008906 ! part of lateral line nerve relationship: BFO:0000050 UBERON:0008906 ! part of lateral line nerve [Term] id: CL:1000073 name: spinal cord radial glial cell def: "Any radial glial cell that is part of some spinal cord." [FBC:Autogenerated] subset: cellxgene_subset subset: human_subset subset: mouse_subset is_a: CL:0000681 ! radial glial cell intersection_of: CL:0000681 ! radial glial cell intersection_of: BFO:0000050 UBERON:0002240 ! part of spinal cord relationship: BFO:0000050 UBERON:0002240 ! part of spinal cord [Term] id: CL:1000082 name: stretch receptor cell subset: human_subset subset: mouse_subset xref: ZFA:0009370 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000006 ! neuronal receptor cell [Term] id: CL:1000083 name: stratified keratinized epithelial stem cell subset: human_subset subset: mouse_subset xref: ZFA:0009371 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000357 ! stratified epithelial stem cell [Term] id: CL:1000085 name: stratified non keratinized epithelial stem cell subset: human_subset subset: mouse_subset is_a: CL:0000357 ! stratified epithelial stem cell [Term] id: CL:1000090 name: pronephric nephron tubule epithelial cell def: "Any epithelial cell that is part of some pronephric nephron tubule." [FBC:Autogenerated] subset: human_subset subset: mouse_subset is_a: CL:1000449 ! epithelial cell of nephron is_a: CL:1000507 ! kidney tubule cell intersection_of: CL:0000066 ! epithelial cell intersection_of: BFO:0000050 UBERON:0005310 ! part of pronephric nephron tubule relationship: BFO:0000050 UBERON:0005310 ! part of pronephric nephron tubule [Term] id: CL:1000123 name: metanephric nephron tubule epithelial cell def: "Any epithelial cell that is part of some metanephric nephron tubule." [FBC:Autogenerated] subset: cellxgene_subset subset: human_subset subset: mouse_subset is_a: CL:1000449 ! epithelial cell of nephron is_a: CL:1000507 ! kidney tubule cell intersection_of: CL:0000066 ! epithelial cell intersection_of: BFO:0000050 UBERON:0005146 ! part of metanephric nephron tubule relationship: BFO:0000050 UBERON:0005146 ! part of metanephric nephron tubule [Term] id: CL:1000143 name: lung goblet cell def: "Any goblet cell that is part of some lung epithelium." [FBC:Autogenerated] subset: cellxgene_subset subset: human_subset subset: mouse_subset is_a: CL:0000082 ! epithelial cell of lung is_a: CL:0002370 ! respiratory tract goblet cell is_a: CL:1000272 ! lung secretory cell intersection_of: CL:0000160 ! goblet cell intersection_of: BFO:0000050 UBERON:0000115 ! part of lung epithelium property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_1000143" xsd:string {name="lung goblet cell on CELLxGENE CellGuide"} property_value: terms:description "Lung goblet cells are critical components of the respiratory tract, specifically found in the bronchial segments. They are secretory epithelial cells known for their signature \"goblet\" or cup-like shape. Their primary function is to produce and secrete mucus that aids in trapping airborne particles and pathogens, preventing them from reaching the delicate environment of the lung. As part of the lung's epithelial lining, they act as frontline defenders, maintaining lung health and function.\nThe lung goblet cells are densely packed with granules containing mucin glycoproteins, the primary component of mucus. As mucus is produced and secreted, it moves towards the lumen of the lungs where the cilia, hair-like structures of the neighboring ciliated epithelial cells, help to navigate it upwards and out of the respiratory tract. This coordinated action ensures the expulsion of unwanted particles and pathogens, effectively cleaning the respiratory tract.\nDysfunction or abnormal proliferation of lung goblet cells can result in pathological conditions such as chronic obstructive pulmonary disorder (COPD) and asthma, where excessive mucus production leads to airway obstruction. Furthermore, lung goblet cells respond to a variety of stimuli, including toxins, allergens, irritants, and infections, adjusting their mucus production accordingly.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1038/s41385-018-0039-y", xref="DOI:10.1038/s41385-020-00370-7", xref="DOI:10.1159/000512268", xref="DOI:10.1513/AnnalsATS.201802-128AW", xref="https://www.ncbi.nlm.nih.gov/books/NBK553208/"} [Term] id: CL:1000147 name: cardiac valve cell def: "A cell that is part of a cardiac valve." [PMID:25311230] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "heart valve cell" EXACT [PMID:30796046] xref: ZFA:0009402 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0002494 ! cardiocyte intersection_of: CL:0000000 ! cell intersection_of: BFO:0000050 UBERON:0000946 ! part of cardiac valve relationship: BFO:0000050 UBERON:0000946 ! part of cardiac valve [Term] id: CL:1000155 name: Malpighian tubule stellate cell def: "A specialized epithelial secretory cell that moves chloride ions and water across the tubule epithelium." [GO:0061330] synonym: "Malpighian tubule Type II cell" EXACT [FBbt:00005797] xref: FBbt:00005797 {sssom:mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"} is_a: CL:0000151 ! secretory cell is_a: CL:0000255 ! eukaryotic cell relationship: BFO:0000050 UBERON:0001054 ! part of Malpighian tubule [Term] id: CL:1000182 name: malpighian tubule tip cell def: "Any tip cell that is part of some Malpighian tubule." [FBC:Autogenerated] is_a: CL:0000255 ! eukaryotic cell is_a: CL:0000423 ! tip cell intersection_of: CL:0000423 ! tip cell intersection_of: BFO:0000050 UBERON:0001054 ! part of Malpighian tubule relationship: BFO:0000050 UBERON:0001054 ! part of Malpighian tubule [Term] id: CL:1000191 name: pillar cell def: "A rod-like cell in the inner ear, having their heads joined and their bases on the basilar membrane widely separated so as to form a spiral tunnel known as the tunnel of Corti." [GOC:tfm, PMID:12417662] subset: human_subset subset: mouse_subset synonym: "cochlear pillar cell" RELATED [] synonym: "pillar cell of cochlea" EXACT [] synonym: "pillar cell of corti" EXACT [] synonym: "rod cell of Corti" EXACT [] xref: FMA:75722 is_a: CL:0002490 ! organ of Corti supporting cell [Term] id: CL:1000217 name: growth plate cartilage chondrocyte def: "Any chondrocyte that is part of some growth plate cartilage." [FBC:Autogenerated] subset: human_subset subset: mouse_subset is_a: CL:0000138 ! chondrocyte intersection_of: CL:0000138 ! chondrocyte intersection_of: BFO:0000050 UBERON:0004129 ! part of growth plate cartilage relationship: BFO:0000050 UBERON:0004129 ! part of growth plate cartilage [Term] id: CL:1000222 name: stomach neuroendocrine cell def: "A specialised neuroendocrine cell located in the gastric mucosa that regulates digestive processes including acid secretion and gut motility. This cell stores hormones in large dense core vesicles and synaptic-like microvesicles." [PMID:15153415] subset: human_subset subset: mouse_subset synonym: "DES cell" BROAD [PMID:15153415] synonym: "diffuse endocrine system cell" BROAD [PMID:15153415] is_a: CL:0000165 ! neuroendocrine cell is_a: CL:1001517 ! stomach enteroendocrine cell intersection_of: CL:0000165 ! neuroendocrine cell intersection_of: BFO:0000050 UBERON:0001276 ! part of epithelium of stomach relationship: RO:0002215 GO:0046717 ! capable of acid secretion [Term] id: CL:1000223 name: pulmonary neuroendocrine cell def: "A neuroendocrine cell that is part of respiratory epithelium of the lung and is involved in the sensory detection of environmental stimuli, including hypoxia, nicotine and air pressure. Ultrastructurally, this cell type is characterized by the presence of cytoplasmic dense core granules, which are considered the storage sites of amine and peptide hormones. Pulmonary neuroendocrine cells are innervated and appear as solitary cells or as clustered masses, localized at airway bifurcation sites, called neuroepithelial bodies that can release serotonin in response to hypoxia and interact with sensory nerve terminals. Pulmonary neuroendocrine cells also function as reserve stem cells that repair the surrounding epithelium after injury." [doi:10.3109/01902148209069653, doi:10.7554/eLife.78216, PMID:33355253] comment: The marker set CHGA, GRP can identify the Human cell type pulmonary neuroendocrine cell in the lung with a confidence of 0.94 (NS-Forest FBeta value). {xref="https://doi.org/10.5281/zenodo.11165918"} subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "lung neuroendocrine cell" EXACT [PMID:15018448] synonym: "PNEC" RELATED OMO:0003000 [PMID:33355253] is_a: CL:0000006 ! neuronal receptor cell is_a: CL:0000098 ! sensory epithelial cell is_a: CL:0000165 ! neuroendocrine cell is_a: CL:0000206 ! chemoreceptor cell is_a: CL:0000458 ! serotonin secreting cell is_a: CL:1000272 ! lung secretory cell intersection_of: CL:0000165 ! neuroendocrine cell intersection_of: BFO:0000050 UBERON:0002048 ! part of lung relationship: BFO:0000051 GO:0031045 ! has part dense core granule relationship: RO:0002215 GO:0070483 ! capable of detection of hypoxia relationship: RO:0015004 CLM:1000043 ! has characterizing marker set NS forest marker set of pulmonary neuroendocrine cell (Human lung). property_value: RO:0002175 NCBITaxon:9606 property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_1000223" xsd:string {name="pulmonary neuroendocrine cell on CELLxGENE CellGuide"} property_value: terms:description "Lung neuroendocrine cells, also commonly known as pulmonary neuroendocrine cells (PNECs), are predominantly located in the respiratory epithelium of the bronchial and bronchiolar airways in the lungs. These cells, characterised by their small size and granular appearance, have a distinctive morphology that sets them apart from other lung cells. They are considered part of the diffuse neuroendocrine system due to their scattered distribution through the epithelium and have been classified into solitary cells and clustered forms known as neuroepithelial bodies.\nThe primary function of PNECs is linked to regulation and maintenance of the lung environment. They are sensory in nature and can secrete various bioactive substances such as serotonin, calcitonin, calcitonin gene-related peptides, and bombesin-like peptides which modulate airway smooth muscle tone and influence gut motility. For example, they act as oxygen sensors in response to hypoxia and are responsible for releasing neuropeptides that can induce responses. Moreover, PNECs provide an afferent function as they are equipped with long microvilli that project into the lumen of the bronchus and react to changes in the chemical composition of the luminal content.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1016/bs.ctdb.2018.12.002", xref="DOI:10.1016/j.devcel.2020.09.024", xref="DOI:10.1242/dmm.046920"} [Term] id: CL:1000236 name: posterior lateral line nerve glial cell def: "Any glial cell that is part of some posterior lateral line nerve." [FBC:Autogenerated] is_a: CL:1000050 ! lateral line nerve glial cell intersection_of: CL:0000125 ! glial cell intersection_of: BFO:0000050 UBERON:2000175 ! part of posterior lateral line nerve relationship: BFO:0000050 UBERON:2000175 ! part of posterior lateral line nerve [Term] id: CL:1000239 name: anterior lateral line nerve glial cell def: "Any glial cell that is part of some anterior lateral line nerve." [FBC:Autogenerated] is_a: CL:1000050 ! lateral line nerve glial cell intersection_of: CL:0000125 ! glial cell intersection_of: BFO:0000050 UBERON:2000425 ! part of anterior lateral line nerve relationship: BFO:0000050 UBERON:2000425 ! part of anterior lateral line nerve [Term] id: CL:1000245 name: posterior lateral line ganglion neuron def: "Any peripheral nervous system neuron that has its soma located in some posterior lateral line ganglion." [FBC:Autogenerated] is_a: CL:2000031 ! lateral line ganglion neuron intersection_of: CL:2000032 ! peripheral nervous system neuron intersection_of: RO:0002100 UBERON:2001314 ! has soma location posterior lateral line ganglion relationship: RO:0002100 UBERON:2001314 ! has soma location posterior lateral line ganglion [Term] id: CL:1000271 name: lung multiciliated epithelial cell def: "An epithelial cell that is part of the lung epithelium. This cell is characterised by the presence of cilia on its apical surface." [PMID:27864314] subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "lung ciliated cell" EXACT [] is_a: CL:0000082 ! epithelial cell of lung is_a: CL:4030034 ! respiratory tract multiciliated cell intersection_of: CL:0000075 ! columnar/cuboidal epithelial cell intersection_of: BFO:0000050 UBERON:0000115 ! part of lung epithelium intersection_of: BFO:0000051 GO:0031514 ! has part motile cilium intersection_of: RO:0000053 PATO:0010007 ! has characteristic multiciliated property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:1000272 name: lung secretory cell def: "Any secretory cell that is part of some lung." [FBC:Autogenerated] subset: cellxgene_subset subset: human_subset subset: mouse_subset is_a: CL:0000151 ! secretory cell is_a: CL:0000255 ! eukaryotic cell intersection_of: CL:0000151 ! secretory cell intersection_of: BFO:0000050 UBERON:0002048 ! part of lung relationship: BFO:0000050 UBERON:0002048 ! part of lung [Term] id: CL:1000274 name: trophectodermal cell def: "An extraembryonic cell that is part of the trophectoderm, representing the first lineage to differentiate in the embryo. This cell is crucial for implantation into the uterine wall and differentiates into trophoblast cells, which contribute to placenta formation and facilitate maternal-fetal nutrient and signal exchange." [PMID:22918806] subset: human_subset subset: mouse_subset synonym: "trophectoderm cell" EXACT [] is_a: CL:0000349 ! extraembryonic cell intersection_of: CL:0000349 ! extraembryonic cell intersection_of: BFO:0000050 UBERON:0004345 ! part of trophectoderm relationship: BFO:0000050 UBERON:0004345 ! part of trophectoderm relationship: RO:0002203 CL:0000351 ! develops into trophoblast cell [Term] id: CL:1000275 name: smooth muscle cell of small intestine def: "A smooth muscle cell that is part of the small intestine." [GOC:tfm] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "non-striated muscle fiber of small intestine" EXACT [FMA:15050] xref: FMA:15050 is_a: CL:0002504 {is_inferred="true"} ! enteric smooth muscle cell intersection_of: CL:0002504 ! enteric smooth muscle cell intersection_of: BFO:0000050 UBERON:0002108 ! part of small intestine relationship: BFO:0000050 UBERON:0002108 ! part of small intestine property_value: foaf:depiction http://purl.obolibrary.org/obo/cl/images/Small-intestine-cells.png {dc:license="http://creativecommons.org/licenses/by/4.0/", xref="doi:10.1186/s13619-020-00061-5", comment="Figure depicts a cross section of intestinal villi in the small intestine, including the crypts of Lieberkuhn (seen here as ‘crypt’), as well as the layer specific locations of cells that exist within the gastrointestinal tract. Layers depicted here include epithelium (rows of cells bordering villus), submucosa (white space below the epithelium containing networks of neurons and ganglia depicted in pink), muscularis mucosae (blue layer), muscularis propria (referred to here as muscle layer).\n\nISC: Intestinal Stem Cell \nTA: Transit Amplifying Cells"} property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_1000275" xsd:string {name="smooth muscle cell of small intestine on CELLxGENE CellGuide"} property_value: terms:description "Smooth muscle cells of the small intestine form a key component of the enteric system which is imperative for gastrointestinal motility. These cells are a specialized subgroup of smooth muscle cells, specifically found in the layers of the small intestine. The small intestine represents a significant part of the digestive system and plays a crucial role in the absorption of nutrients into the bloodstream.\nSmooth muscle cells of the small intestine are predominantly responsible for creating the contractions and relaxations that constitute intestinal motility. They trigger these movements in a coordinated and rhythmic manner known as peristalsis and segmentation. Peristalsis is a form of longitudinal and sequential contraction that pushes food from the upper gastrointestinal tract to the lower parts. Segmentation works by squeezing the intestine randomly, thereby facilitating the mixing of food particles and increasing contact with absorptive surfaces. These two processes are critical for intestinal motility and an effective digestive process.\nApart from facilitating transit of food through contractions, these smooth muscle cells play a role in controlling the diameter of the vessels and the blood flow in the small intestine by their constrictive ability. These smooth muscle cells also contribute to the structural integrity of the small intestine by forming a part of its muscularis externa and muscularis mucosae. Additionally, they interact with other cell types such as enteric neurons and interstitial cells of Cajal (ICC), forming an integrated cellular network that ensures optimal functioning of the intestinal tract.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1007/978-981-13-5895-1_1", xref="DOI:10.1038/nrgastro.2012.168", xref="DOI:10.1038/s41575-020-0271-2", xref="DOI:10.1053/j.gastro.2016.02.030", xref="DOI:10.1111/j.1582-4934.2008.00352.x"} [Term] id: CL:1000276 name: smooth muscle fiber of duodenum def: "A smooth muscle cell that is part of the duodenum." [GOC:tfm] subset: human_subset subset: mouse_subset synonym: "non-striated muscle fiber of duodenum" EXACT [FMA:15058] xref: FMA:15058 is_a: CL:1000275 {is_inferred="true"} ! smooth muscle cell of small intestine intersection_of: CL:1000275 ! smooth muscle cell of small intestine intersection_of: BFO:0000050 UBERON:0002114 ! part of duodenum relationship: BFO:0000050 UBERON:0001902 ! part of epithelium of small intestine relationship: BFO:0000050 UBERON:0002114 ! part of duodenum [Term] id: CL:1000277 name: smooth muscle fiber of jejunum def: "A smooth muscle cell that is part of the jejunum." [GOC:tfm] subset: human_subset subset: mouse_subset synonym: "non-striated muscle fiber of jejunum" EXACT [FMA:15062] xref: FMA:15062 is_a: CL:1000275 {is_inferred="true"} ! smooth muscle cell of small intestine intersection_of: CL:1000275 ! smooth muscle cell of small intestine intersection_of: BFO:0000050 UBERON:0002115 ! part of jejunum relationship: BFO:0000050 UBERON:0002115 ! part of jejunum [Term] id: CL:1000278 name: smooth muscle fiber of ileum def: "A smooth muscle cell that is part of the ileum." [GOC:tfm] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "non-striated muscle fiber of ileum" EXACT [FMA:15066] xref: FMA:15066 is_a: CL:1000275 {is_inferred="true"} ! smooth muscle cell of small intestine intersection_of: CL:1000275 ! smooth muscle cell of small intestine intersection_of: BFO:0000050 UBERON:0002116 ! part of ileum relationship: BFO:0000050 UBERON:0001902 ! part of epithelium of small intestine relationship: BFO:0000050 UBERON:0002116 ! part of ileum property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_1000278" xsd:string {name="smooth muscle fiber of ileum on CELLxGENE CellGuide"} property_value: terms:description "The smooth muscle fiber of the ileum primarily refers to a specific class of muscle cells present in the ileum, the final segment of the small intestine. Distinguished from skeletal muscle and cardiac muscle, smooth muscle does not possess striations and is under the control of the involuntary nervous system. \nThese cells primarily facilitate the movement of digested food, a process known as peristalsis. These cells coordinate rhythmic contractions and relaxations, propelling the chyme toward the colon. This process is vital for efficient nutrient absorption in the small intestine and the transfer of undigested material to the large intestine. Moreover, the smooth muscle fibers enhance the ileum's ability to expand and adapt to volume changes without elevating internal pressure, known as compliance.\nThe smooth muscle fiber of the ileum contributes to reflex responses, enhancing muscle contractions to propel intestinal contents in different physiological conditions. This involves intricate molecular signaling with neurotransmitters, hormones, and local signals. Thus, beyond its structural role, the smooth muscle fiber is crucial for the physiological functions of digestion and absorption in the small intestine.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1152/advan.00025.2003", xref="https://www.ncbi.nlm.nih.gov/books/NBK532857/", xref="https://www.ncbi.nlm.nih.gov/books/NBK556137/"} [Term] id: CL:1000279 name: smooth muscle cell of large intestine def: "A smooth muscle cell that is part of the large intestine." [GOC:tfm] subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "non-striated muscle fiber of large intestine" EXACT [FMA:15653] xref: FMA:15653 is_a: CL:0002504 {is_inferred="true"} ! enteric smooth muscle cell intersection_of: CL:0002504 ! enteric smooth muscle cell intersection_of: BFO:0000050 UBERON:0000059 ! part of large intestine relationship: BFO:0000050 UBERON:0000059 ! part of large intestine property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:1000280 name: smooth muscle cell of colon def: "A smooth muscle cell that is part of the colon." [GOC:tfm] subset: human_subset subset: mouse_subset synonym: "non-striated muscle fiber of colon" EXACT [FMA:15663] xref: FMA:15663 is_a: CL:1000279 ! smooth muscle cell of large intestine intersection_of: CL:0002504 ! enteric smooth muscle cell intersection_of: BFO:0000050 UBERON:0001155 ! part of colon relationship: BFO:0000050 UBERON:0001155 ! part of colon relationship: BFO:0000050 UBERON:0001278 ! part of epithelium of large intestine [Term] id: CL:1000281 name: smooth muscle cell of cecum def: "A smooth muscle cell that is part of the cecum." [GOC:tfm] subset: human_subset subset: mouse_subset synonym: "non-striated muscle fiber of cecum" EXACT [FMA:15681] synonym: "smooth muscle fiber of cecum" EXACT [] xref: FMA:15681 is_a: CL:1000280 ! smooth muscle cell of colon intersection_of: CL:0000192 ! smooth muscle cell intersection_of: BFO:0000050 UBERON:0001153 ! part of caecum relationship: BFO:0000050 UBERON:0001153 ! part of caecum [Term] id: CL:1000282 name: smooth muscle fiber of ascending colon def: "A smooth muscle cell that is part of the ascending colon." [GOC:tfm] subset: human_subset subset: mouse_subset synonym: "non-striated muscle fiber of ascending colon" EXACT [FMA:17518] xref: FMA:17518 is_a: CL:1000280 {is_inferred="true"} ! smooth muscle cell of colon intersection_of: CL:1000280 ! smooth muscle cell of colon intersection_of: BFO:0000050 UBERON:0001156 ! part of ascending colon relationship: BFO:0000050 UBERON:0001156 ! part of ascending colon [Term] id: CL:1000283 name: smooth muscle fiber of transverse colon def: "A smooth muscle cell that is part of the transverse colon." [GOC:tfm] subset: human_subset subset: mouse_subset synonym: "non-striated muscle fiber of transverse colon" EXACT [FMA:17519] xref: FMA:17519 is_a: CL:1000280 {is_inferred="true"} ! smooth muscle cell of colon intersection_of: CL:1000280 ! smooth muscle cell of colon intersection_of: BFO:0000050 UBERON:0001157 ! part of transverse colon relationship: BFO:0000050 UBERON:0001157 ! part of transverse colon [Term] id: CL:1000284 name: smooth muscle fiber of descending colon def: "A smooth muscle cell that is part of the descending colon." [GOC:tfm] subset: human_subset subset: mouse_subset synonym: "non-striated muscle fiber of descending colon" EXACT [FMA:17520] xref: FMA:17520 is_a: CL:1000280 {is_inferred="true"} ! smooth muscle cell of colon intersection_of: CL:1000280 ! smooth muscle cell of colon intersection_of: BFO:0000050 UBERON:0001158 ! part of descending colon relationship: BFO:0000050 UBERON:0001158 ! part of descending colon [Term] id: CL:1000285 name: smooth muscle cell of sigmoid colon def: "A smooth muscle cell that is part of the sigmoid colon." [GOC:tfm] subset: human_subset subset: mouse_subset synonym: "non-striated muscle fiber of sigmoid colon" EXACT [FMA:17521] xref: FMA:17521 is_a: CL:1000280 {is_inferred="true"} ! smooth muscle cell of colon intersection_of: CL:1000280 ! smooth muscle cell of colon intersection_of: BFO:0000050 UBERON:0001159 ! part of sigmoid colon relationship: BFO:0000050 UBERON:0001159 ! part of sigmoid colon [Term] id: CL:1000286 name: smooth muscle cell of rectum def: "A smooth muscle cell that is part of the rectum." [GOC:tfm] subset: human_subset subset: mouse_subset synonym: "non-striated muscle fiber of rectum" EXACT [FMA:17522] synonym: "smooth muscle fiber of rectum" EXACT [] xref: FMA:17522 is_a: CL:1000279 ! smooth muscle cell of large intestine intersection_of: CL:0000192 ! smooth muscle cell intersection_of: BFO:0000050 UBERON:0001052 ! part of rectum relationship: BFO:0000050 UBERON:0001052 ! part of rectum relationship: BFO:0000050 UBERON:0001278 ! part of epithelium of large intestine [Term] id: CL:1000287 name: myocyte of anterior internodal tract def: "A muscle cell that is part of the anterior internodal tract." [GOC:tfm] subset: human_reference_atlas subset: human_subset subset: mouse_subset xref: FMA:223276 is_a: CL:0002096 ! internodal tract myocyte property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:1000288 name: myocyte of atrial branch of anterior internodal tract def: "A muscle cell that is part of the atrial branch of anterior internodal tract." [GOC:tfm] subset: human_subset subset: mouse_subset xref: FMA:223277 is_a: CL:0002096 ! internodal tract myocyte [Term] id: CL:1000289 name: myocyte of atrial septal branch of anterior internodal tract def: "A muscle cell that is part of the atrial septal branch of anterior internodal tract." [GOC:tfm] subset: human_subset subset: mouse_subset xref: FMA:223278 is_a: CL:0002096 ! internodal tract myocyte [Term] id: CL:1000290 name: myocyte of middle internodal tract def: "A muscle cell that is part of the middle internodal tract." [GOC:tfm] subset: human_reference_atlas subset: human_subset subset: mouse_subset xref: FMA:223279 is_a: CL:0002096 ! internodal tract myocyte property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:1000291 name: myocyte of posterior internodal tract def: "A muscle cell that is part of the posterior internodal tract." [GOC:tfm] subset: human_reference_atlas subset: human_subset subset: mouse_subset xref: FMA:223280 is_a: CL:0002096 ! internodal tract myocyte property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:1000296 name: epithelial cell of urethra def: "An epithelial cell that is part of the urethra." [GOC:tfm] subset: cellxgene_subset subset: human_subset subset: mouse_subset xref: FMA:256165 is_a: CL:0000066 ! epithelial cell is_a: CL:1001320 ! urethra cell intersection_of: CL:0000066 ! epithelial cell intersection_of: BFO:0000050 UBERON:0000057 ! part of urethra property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_1000296" xsd:string {name="epithelial cell of urethra on CELLxGENE CellGuide"} property_value: terms:description "Epithelial cells of the urethra constitute the inner lining of the urethra, forming a mucosal barrier that helps protect the body from external contaminants. The type of epithelial cells found in the urethra can vary along its length. In general, the urethra is lined with stratified squamous epithelium in its distal or external portion, which is closer to the external environment. This type of epithelium provides protection against mechanical stress and pathogens. Closer to the bladder, the urethra transitions to a different type of epithelium. In males, the proximal part of the urethra is lined with pseudostratified columnar epithelium in the region where it passes through the prostate gland. In females, the transitional epithelium may be present in the proximal part of the urethra near the bladder.\nEpithelial cells of the urethra are primarily dedicated to the protection of underlying tissues from mechanical stress and pathogens during micturition (urination). They do this by creating a tight, impermeable barrier that prevents the entry and colonization of invading microbes. They produce a variety of antimicrobials and are tightly packed to prevent infiltration between cells, forming an integral part of the body's innate immune system.\nIn addition to their protective role, these cells are involved in the secretion of mucus. This mucus acts as a lubricant that ensures the smooth and easy passage of urine from the bladder through the urethra and out of the body, reducing any potential damage from the erosive action of urine. Epithelial cells of the urethra are dynamic, constantly renewing their numbers to replace any cells lost through wear and tear. Any disruptions to the function or integrity of these cells may contribute to urinary tract infections and other urological disorders.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1016/j.celrep.2018.11.086", xref="DOI:10.1038/s41385-022-00565-0", xref="DOI:10.1089/ten.teb.2016.0352", xref="DOI:10.1101/2020.02.19.937615v2.full", xref="DOI:10.1152/ajprenal.00327.2009"} [Term] id: CL:1000298 name: mesothelial cell of dura mater def: "A mesothelial cell that is part of the dura mater." [GOC:tfm] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "squamous mesothelial cell of dura mater" EXACT [FMA:256516] xref: FMA:256516 is_a: CL:0000077 ! mesothelial cell is_a: CL:0002319 ! neural cell intersection_of: CL:0000077 ! mesothelial cell intersection_of: BFO:0000050 UBERON:0002363 ! part of dura mater relationship: BFO:0000050 UBERON:0002363 ! part of dura mater [Term] id: CL:1000299 name: fibroblast of connective tissue of prostate def: "A fibroblast that is part of the connective tissue of prostate." [GOC:tfm] subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset xref: FMA:261271 is_a: CL:0000057 ! fibroblast is_a: CL:0002622 ! prostate stromal cell property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/2d-ftu/prostate-prostate-glandular-acinus/v1.2/assets/2d-ftu-prostate-prostate-glandular-acinus.png" xsd:string {terms:licence="http://creativecommons.org/licenses/by/4.0/", xref="doi:10.48539/HBM347.TXWZ.899"} property_value: RO:0002175 NCBITaxon:9606 property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_1000299" xsd:string {name="fibroblast of connective tissue of prostate on CELLxGENE CellGuide"} property_value: terms:description "The fibroblasts of connective tissue of the prostate are responsible for the production and maintenance of the extracellular matrix in the stromal region of the prostate gland. Fibroblasts, in general, are ubiquitous in the body's connective tissues, playing vital roles in wound healing and tissue repair. However, within the prostate, these cells exhibit unique characteristics targeted at the organ's health and function, permitting dynamic interactions with other cell types and fostering tissue architecture.\nFibroblasts found in the prostate contribute significantly to the organ's function, particularly in maintaining tissue health and structure. These cells synthesize major structural proteins, such as collagen, elastin, and glycosaminoglycans—components of the extracellular matrix that provide structural support to the prostate tissue. This ensures the prostate's smooth muscle maintains its capability to contract and expand, thereby enabling proper function during urination and ejaculation. Furthermore, as the prostate gland undergoes adaptive alterations in response to ageing, fibroblasts play an integral role in coordinating these changes through their ability to modulate the extracellular matrix.\nBeyond maintaining tissue structure, the fibroblast of connective tissue of the prostate also participates actively in paracrine signaling—communication with other cell types within the prostate. Such cross-talk is especially significant in settings of inflammation, tissue injury, and in the pathogenesis of diseases such as benign prostatic hyperplasia and prostate cancer. In disease states, these fibroblasts can transition to a reactive phenotype characterized by increased proliferation and secretion of growth factors and pro-inflammatory cytokines. This transition excessively modulates the extracellular matrix, contributing to the diseased state.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1002/pros.23867", xref="DOI:10.1038/s41416-022-02085-x", xref="DOI:10.1101/cshperspect.a030510", xref="DOI:10.1530/ERC-12-0085", xref="DOI:10.3390/jcm7040068"} [Term] id: CL:1000300 name: fibroblast of outer membrane of prostatic capsule def: "A fibroblast that is part of the outer membrane of prostatic capsule." [GOC:tfm] subset: human_subset subset: mouse_subset xref: FMA:261273 is_a: CL:0000057 ! fibroblast is_a: CL:0002622 ! prostate stromal cell [Term] id: CL:1000301 name: fibroblast of subepithelial connective tissue of prostatic gland def: "A fibroblast that is part of the subepithelial connective tissue of prostatic gland." [GOC:tfm] subset: human_reference_atlas subset: human_subset subset: mouse_subset xref: FMA:261275 is_a: CL:0000057 ! fibroblast is_a: CL:0002622 ! prostate stromal cell property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/2d-ftu/prostate-prostate-glandular-acinus/v1.2/assets/2d-ftu-prostate-prostate-glandular-acinus.png" xsd:string {terms:licence="http://creativecommons.org/licenses/by/4.0/", xref="doi:10.48539/HBM347.TXWZ.899"} property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:1000302 name: fibroblast of papillary layer of dermis def: "A fibroblast that is part of the papillary layer of dermis." [GOC:tfm] subset: human_subset subset: mouse_subset xref: FMA:261277 is_a: CL:0002551 {is_inferred="true"} ! fibroblast of dermis intersection_of: CL:0002551 ! fibroblast of dermis intersection_of: BFO:0000050 UBERON:0001992 ! part of papillary layer of dermis relationship: BFO:0000050 UBERON:0001992 ! part of papillary layer of dermis [Term] id: CL:1000303 name: fibroblast of areolar connective tissue def: "A fibroblast that is part of the areolar connective tissue." [GOC:tfm] subset: human_subset subset: mouse_subset xref: FMA:261279 is_a: CL:0000057 {is_inferred="true"} ! fibroblast intersection_of: CL:0000057 ! fibroblast intersection_of: BFO:0000050 UBERON:0006815 ! part of areolar connective tissue relationship: BFO:0000050 UBERON:0006815 ! part of areolar connective tissue [Term] id: CL:1000304 name: fibroblast of connective tissue of nonglandular part of prostate def: "A fibroblast that is part of the connective tissue of nonglandular part of prostate." [GOC:tfm] subset: cellxgene_subset subset: human_subset subset: mouse_subset xref: FMA:261281 is_a: CL:0000057 ! fibroblast is_a: CL:0002622 ! prostate stromal cell property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_1000304" xsd:string {name="fibroblast of connective tissue of nonglandular part of prostate on CELLxGENE CellGuide"} property_value: terms:description "Fibroblasts of connective tissue of nonglandular part of the prostate, also referred to as prostatic stromal fibroblasts, are specialized cells that are instrumental in maintaining the structure and function of the prostate. These cells constitute a crucial part of the non-glandular or stromal compartment of the prostate, which is composed largely of connective tissue and smooth muscle fibers. Being the most abundant cell type in the prostate stroma, fibroblasts are responsible for the production and maintenance of the extracellular matrix (ECM) via synthesis of collagen and elastin, structural proteins that provides crucial supportive and adhesive framework for the glandular elements of the prostate. These proteins provide tensile strength and elasticity, respectively, contributing to the healthy architecture of the prostate tissue. These cells also play a significant role in coordinating intercellular communication within the prostate by interacting with adjacent epithelial cells, endothelial cells, immune cells, and nerve cells, affecting cell growth, differentiation, and function.\nProstatic stromal fibroblasts are actively involved in modulating local immune responses and tissue repair. Acting as local immunomodulatory cells, they can secrete a variety of cytokines and chemokines, influencing the functions of immune cells in the prostate microenvironment. Similarly, under pathological conditions, such as tissue injury or inflammation, these fibroblasts can transition into a more activated state, known as myofibroblasts, driving wound healing and tissue remodeling processes. It's worth noting that aberrant activation and proliferation of these fibroblasts can contribute to pathological situations, such as prostatic hyperplasia and prostate cancer, underscoring their importance in both health and disease.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1016/j.ajpath.2013.11.015", xref="DOI:10.1038/s41416-022-02085-x", xref="DOI:10.1101/cshperspect.a030510", xref="DOI:10.1210/me.2010-0340", xref="DOI:10.3892/ijmm.18.5.941"} [Term] id: CL:1000305 name: fibroblast of connective tissue of glandular part of prostate def: "A fibroblast that is part of the connective tissue of glandular part of prostate." [GOC:tfm] subset: cellxgene_subset subset: human_subset subset: mouse_subset xref: FMA:261283 is_a: CL:0000057 ! fibroblast is_a: CL:0002622 ! prostate stromal cell property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_1000305" xsd:string {name="fibroblast of connective tissue of glandular part of prostate on CELLxGENE CellGuide"} property_value: terms:description "Fibroblasts of the connective tissue of the glandular part of the prostate are fibroblasts found within the connective tissue encapsulating and supporting the glandular tissues in the prostate. These cells are responsible for producing and maintaining the extracellular matrix (ECM), a critical component of any connective tissue. The ECM provides a crucial scaffold or architecture for the tissue and plays a pivotal role in cell behavior and function. \nFibroblast cells in the prostate, in particular, are involved in the regulation of the glandular activities, contributing to the homeostasis of this organ, primarily through their ability to secrete various growth factors, cytokines, and enzymes. They help regulate the growth and differentiation of prostatic epithelial cells, thus playing a role in maintaining proper glandular structure and function. Furthermore, these cells serve as a key conduit of intercellular communication due to their reciprocal interaction with the surrounding epithelial and stromal cells, influencing various aspects of cellular function such as proliferation, differentiation, and migration. \nAdditionally, these cells have a significant part in pathological conditions that hit the prostate including prostate cancer and benign prostatic hyperplasia (BPH). In particular, when the prostate is afflicted by cancer, the fibroblasts are known to undergo a reactive change, transforming into myofibroblasts. These altered fibroblasts then exacerbate the disease by encouraging cancer cell growth and invasion, and promoting angiogenesis. Conversely, in BPH, the fibroblasts contribute to the excessive growth of prostatic tissue.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1016/j.diff.2011.05.007", xref="DOI:10.1016/j.ucl.2016.04.012", xref="DOI:10.1101/cshperspect.a030510", xref="DOI:10.3390/cancers12071887"} [Term] id: CL:1000306 name: fibroblast of tunica adventitia of artery def: "A fibroblast that is part of the tunica adventitia of artery." [GOC:tfm] subset: human_subset subset: mouse_subset xref: FMA:261285 is_a: CL:4052030 ! adventitial fibroblast intersection_of: CL:0000057 ! fibroblast intersection_of: BFO:0000050 UBERON:0007240 ! part of tunica adventitia of artery relationship: BFO:0000050 UBERON:0007240 ! part of tunica adventitia of artery [Term] id: CL:1000307 name: fibroblast of dense regular elastic tissue def: "A fibroblast that is part of the dense regular elastic tissue." [GOC:tfm] subset: human_subset subset: mouse_subset xref: FMA:261287 is_a: CL:0000057 ! fibroblast intersection_of: CL:0000057 ! fibroblast intersection_of: BFO:0000050 UBERON:0007846 ! part of dense regular connective tissue relationship: BFO:0000050 UBERON:0002521 ! part of elastic tissue relationship: BFO:0000050 UBERON:0007846 ! part of dense regular connective tissue [Term] id: CL:1000308 name: fibrocyte of adventitia of ureter def: "A stromal cell that is part of the outer adventitial layer of the ureter. This cell type is marked by expression of periostin (POSTN) in mice, and it is derived from Foxd1+ mesenchymal progenitors around embryonic day 12.5. The adventitial fibrocyte initiates differentiation earlier than smooth muscle cells and becomes terminally differentiated by E16.5-18.5 in mice, exhibiting low proliferative capacity in adulthood." [GOC:tfm, PMID:28028137] subset: human_reference_atlas subset: human_subset subset: mouse_subset xref: FMA:261289 is_a: CL:0000499 ! stromal cell is_a: CL:1000708 ! ureter adventitial cell relationship: RO:0002292 PR:000013031 ! expresses periostin property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:1000309 name: epicardial adipocyte def: "An adipocyte that is part of the epicardial fat." [GOC:tfm] subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "adipocyte of epicardial fat" EXACT [FMA:261293] synonym: "epicardial fat cell" EXACT [FMA:261293] xref: FMA:261293 is_a: CL:0000136 ! adipocyte is_a: CL:0002494 ! cardiocyte relationship: BFO:0000050 UBERON:0002348 ! part of epicardium property_value: RO:0002175 NCBITaxon:9606 property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_1000309" xsd:string {name="epicardial adipocyte on CELLxGENE CellGuide"} property_value: terms:description "Epicardial adipocytes are a type of specialized cell found in the epicardial adipose tissue (EAT). This specific adipose tissue is located between the myocardium (the heart muscle) and the visceral pericardium (the innermost layer of the pericardium). Epicardial adipocytes store energy in the form of lipids; specifically, triglyceride droplets. These cells can rapidly mobilize and release these fatty acid molecules, when required, providing an effective and efficient energy source to the body. This energy is particularly important to the heart, which is one of the highest energy-demanding organs. The proximity of these specialized cells to the myocardium allows for direct and rapid transmission of these fatty acid molecules to meet the heart’s energy needs. \nBeyond their primary role in energy storage and regulation, epicardial adipocytes also play a pivotal role in providing a protective cushioning to the heart, releasing several beneficial adipokines which impacts cardiac function, along with acting as a source of stem cells. Adipocytes also contribute significantly to cardiac health and function in other ways. They have been found to secrete multiple bioactive molecules, known as adipokines, which can influence local cardiac function and overall cardiovascular health. Adipokines such as adiponectin, leptin and resistin regulate aspects of cardiac metabolism, inflammation, and contractility. Additionally, studies have also pointed towards epicardial adipocytes as a potential reservoir of adult epicardial progenitor cells, which can give rise to smooth muscle cells, endothelial cells and more adipocytes, thus contributing to cardiac repair and regeneration. Despite these important functions, an excess of epicardial adipose tissue has been associated with cardiovascular disease, indicating the importance of understanding and managing the balance of these unique cells in the body.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1016/j.tem.2011.07.003", xref="DOI:10.1038/ncpcardio0319", xref="DOI:10.1038/s41569-022-00679-9", xref="DOI:10.3390/biology11030355", xref="DOI:10.3978/j.issn.2223-3652.2014.11.05"} [Term] id: CL:1000310 name: adipocyte of epicardial fat of right ventricle def: "An adipocyte that is part of the epicardial fat of right ventricle." [GOC:tfm] subset: human_subset subset: mouse_subset synonym: "epicardial adipocyte of right ventricle" EXACT [FMA:261297] synonym: "epicardial fat cell of right ventricle" EXACT [FMA:261297] xref: FMA:261297 is_a: CL:1000309 ! epicardial adipocyte intersection_of: CL:1000309 ! epicardial adipocyte intersection_of: BFO:0000050 UBERON:0002080 ! part of heart right ventricle relationship: BFO:0000050 UBERON:0002080 ! part of heart right ventricle [Term] id: CL:1000311 name: adipocyte of epicardial fat of left ventricle def: "An adipocyte that is part of the epicardial fat of left ventricle." [GOC:tfm] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "epicardial adipocyte of left ventricle" EXACT [FMA:261300] synonym: "epicardial fat cell of left ventricle" EXACT [FMA:261300] xref: FMA:261300 is_a: CL:1000309 ! epicardial adipocyte intersection_of: CL:1000309 ! epicardial adipocyte intersection_of: BFO:0000050 UBERON:0002084 ! part of heart left ventricle relationship: BFO:0000050 UBERON:0002084 ! part of heart left ventricle property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_1000311" xsd:string {name="adipocyte of epicardial fat of left ventricle on CELLxGENE CellGuide"} property_value: terms:description "Adipocytes of the epicardial fat of the left ventricle are specialized cells localized within the epicardial adipose tissue, which is found enveloping the heart's outer layer, particularly the left ventricle. The primary function of these adipocytes is the storage and release of energy in the form of lipids, which facilitates efficient energy transfer to the myocardium when necessary. They are mesenchymal-derived cells filled with lipid droplets, giving them a unique and distinct appearance when compared to other cell types.\nThe secondary, yet critically important function of these adipocytes revolves around their role as endocrine cells. They're involved in the production and secretion of various bioactive molecules, such as adiponectin, resistin, leptin, cytokines, and other adipocytokines, which play crucial roles in local and systemic metabolism, inflammatory responses, and myocardial protection. Furthermore, these adipocytes serve as a thermal insulation layer for the heart, protecting it from hypothermia and potentially mitigating the risk of arrhythmias caused by abrupt temperature changes.\nDysregulation of the adipocytes of the epicardial fat of the left ventricle in their functions can lead to pathological conditions such as obesity, diabetes, and cardiovascular diseases like coronary artery disease and heart failure. For instance, it has been observed that increased volume of epicardial adipose tissue could be linked to the development of coronary atherosclerosis.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1038/ncpcardio0319", xref="DOI:10.1038/s41598-023-41779-x", xref="DOI:10.1093/eurheartj/ehab724.1266", xref="DOI:10.1186/s12933-017-0528-4", xref="DOI:10.3390/ijms24076838"} [Term] id: CL:1000312 name: bronchial goblet cell def: "A goblet cell that is part of the epithelium of bronchus." [GOC:tfm] comment: The marker set PLCG2, ANKRD36C can identify the Human cell type bronchial goblet cell in the lung with a confidence of 0.55 (NS-Forest FBeta value). {xref="https://doi.org/10.5281/zenodo.11165918"} subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "goblet cell of epithelium of bronchus" EXACT [FMA:263032] xref: FMA:263032 is_a: CL:0002328 ! bronchial epithelial cell is_a: CL:0019003 ! tracheobronchial goblet cell intersection_of: CL:0000160 ! goblet cell intersection_of: BFO:0000050 UBERON:0002185 ! part of bronchus relationship: RO:0015004 CLM:1000026 ! has characterizing marker set NS forest marker set of bronchial goblet cell (Human lung). property_value: RO:0002175 NCBITaxon:9606 property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_1000312" xsd:string {name="bronchial goblet cell on CELLxGENE CellGuide"} property_value: terms:description "Bronchial goblet cells are a subset of goblet cells that are predominantly found in the respiratory tract, specifically within the bronchi and bronchioles. Named for their flask-like shape and their apparent similarity to a goblet, these cells contribute significantly to the maintenance of lung health and homeostasis. In humans, goblet cells comprise up to 25% of the bronchial epithelial columnar cells and are an integral part of the mucus-secreting system of the respiratory tract and are primarily responsible for the production and secretion of mucus.\nThe mucus secreted by bronchial goblet cells serves as a protective layer over the delicate and sensitive structures of the bronchi. The mucus, an amalgamation of glycoproteins, lipids, and other substances, traps any inhaled dust, microorganisms, and pollutants, preventing them from reaching deeper lung tissues and causing potential damage. Additionally, the mucus secretion aids in moistening the airway surface, thereby facilitating effective gas exchange and maintaining the overall health of the respiratory tract.\nBronchial goblet cells have an innate defense mechanism wherein they increase secretion of mucus in response to irritants, infection or inflammation in the airway. This strategy, however, if incessantly stimulated, can lead to airway obstruction and health complications like asthma and chronic obstructive pulmonary disease (COPD).\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1016/S0165-6147(00)01600-X", xref="DOI:10.1016/S1357-2725(02)00083-3", xref="DOI:10.1080/07853890600585795", xref="DOI:10.2147/COPD.S38938"} [Term] id: CL:1000313 name: gastric goblet cell def: "A goblet cell that is part of the epithelium of stomach." [GOC:tfm] subset: human_subset subset: mouse_subset synonym: "goblet cell of epithelium of stomach" EXACT [FMA:263035] xref: FMA:263035 is_a: CL:0000160 ! goblet cell is_a: CL:0002180 ! mucous cell of stomach intersection_of: CL:0000160 ! goblet cell intersection_of: BFO:0000050 UBERON:0000945 ! part of stomach [Term] id: CL:1000314 name: gastric cardiac gland goblet cell def: "A goblet cell that is part of the epithelium of gastric cardiac gland." [GOC:tfm] subset: human_subset subset: mouse_subset synonym: "goblet cell of epithelium of gastric cardiac gland" EXACT [] xref: FMA:263038 is_a: CL:0000152 ! exocrine cell is_a: CL:0002659 ! glandular epithelial cell of stomach is_a: CL:1000313 ! gastric goblet cell intersection_of: CL:0000160 ! goblet cell intersection_of: BFO:0000050 UBERON:0008859 ! part of cardiac gastric gland [Term] id: CL:1000315 name: principal gastric gland goblet cell def: "A goblet cell that is part of the epithelium of principal gastric gland." [GOC:tfm] subset: human_subset subset: mouse_subset synonym: "goblet cell of epithelium of principal gastric gland" EXACT [] xref: FMA:263040 is_a: CL:0000152 ! exocrine cell is_a: CL:0002659 ! glandular epithelial cell of stomach is_a: CL:1000313 ! gastric goblet cell intersection_of: CL:0000160 ! goblet cell intersection_of: BFO:0000050 UBERON:0009971 ! part of principal gastric gland relationship: BFO:0000050 UBERON:0009971 ! part of principal gastric gland [Term] id: CL:1000316 name: obsolete goblet cell of epithelium of small intestine def: "OBSOLETE: A goblet cell that is part of the epithelium of small intestine." [GOC:tfm] xref: FMA:263042 is_obsolete: true replaced_by: CL:1000495 [Term] id: CL:1000317 name: intestinal villus goblet cell def: "A goblet cell that is part of the epithelium of intestinal villus." [GOC:tfm] subset: human_subset subset: mouse_subset synonym: "goblet cell of epithelium of intestinal villus" EXACT [] xref: FMA:263046 is_a: CL:1000495 ! small intestine goblet cell intersection_of: CL:0000160 ! goblet cell intersection_of: BFO:0000050 UBERON:0013636 ! part of epithelium of intestinal villus relationship: BFO:0000050 UBERON:0013636 ! part of epithelium of intestinal villus [Term] id: CL:1000318 name: obsolete small intestine crypt goblet cell def: "A goblet cell that is part of the epithelium of crypt of lieberkuhn of small intestine." [GOC:tfm] xref: FMA:263050 is_obsolete: true [Term] id: CL:1000319 name: obsolete goblet cell of epithelium proper of small intestine def: "OBSOLETE: A goblet cell that is part of the epithelium proper of small intestine." [GOC:tfm] xref: FMA:263052 is_obsolete: true [Term] id: CL:1000320 name: large intestine goblet cell def: "A goblet cell that is part of the epithelium of large intestine." [GOC:tfm] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "goblet cell of epithelium of large intestine" EXACT [] xref: FMA:263054 is_a: CL:0002253 ! epithelial cell of large intestine is_a: CL:0019031 ! intestine goblet cell intersection_of: CL:0000160 ! goblet cell intersection_of: BFO:0000050 UBERON:0001278 ! part of epithelium of large intestine property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_1000320" xsd:string {name="large intestine goblet cell on CELLxGENE CellGuide"} property_value: terms:description "The large intestine goblet cell is a highly specialized type of mucosal epithelial cell that is located within the epithelial lining of the large intestine. The key function of goblet cells is the production and secretion of a protective layer of mucus which is essential for maintaining gut homeostasis. Goblet cells have a characteristic 'goblet-like' shape, which adapts them for this specific function: organelles such as the nucleus, mitochondria, ER, and Golgi apparatus are located in the basal portion of the cell; while the vesicles with mucins (required for mucus production) are located apically, close to the apical membrane where their exocytosis takes place.\nThe goblet cells of the large intestine produce a thick layer of mucus that coats the intestinal lumen. This mucus provides a barrier that prevents the direct contact of intestinal cells with bacteria and other potentially toxic substances present in the digestive tract. It also lubricates the intestine to facilitate the smooth passage of digested food material. It is worth noting that the mucus system differs between the small and large intestine: although in both the mucus is built around MUC2 mucin polymers produced by goblet cells, it is becoming clear that there are several types of goblet cells that function in different ways. \nFrom an immunological perspective, large intestine goblet cells participate in promoting a balanced gut immune response. They contribute to the process known as immune tolerance, where they prevent the body's immune system from overreacting to the trillions of bacteria present in the gut. These cells achieve this by secreting molecules that help maintain a calm environment, limiting inflammatory reactions unless absolutely necessary. Any dysfunction or decrease in the number of goblet cells can result in a compromised intestinal barrier leading to various health issues, including inflammatory bowel disease.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1038/mi.2015.32", xref="DOI:10.1042/BSR20201471", xref="DOI:10.1111/imr.12182", xref="DOI:10.1146/annurev-physiol-021115-105447", xref="DOI:full/10.1111/febs.15731"} [Term] id: CL:1000321 name: large intestine crypt goblet cell def: "A goblet cell that is part of the epithelium of crypt of Lieberkuhn of large intestine." [GOC:tfm] subset: human_reference_atlas subset: human_subset subset: mouse_subset xref: FMA:263056 is_a: CL:0002658 ! glandular cell of the large intestine is_a: CL:1000320 ! large intestine goblet cell intersection_of: CL:0000160 ! goblet cell intersection_of: BFO:0000050 UBERON:0022281 ! part of epithelium of crypt of Lieberkuhn of large intestine relationship: BFO:0000050 UBERON:0022281 ! part of epithelium of crypt of Lieberkuhn of large intestine property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/2d-ftu/large-intestine-crypt-lieberkuhn/v1.2/assets/2d-ftu-large-intestine-crypt-lieberkuhn.png" xsd:string {terms:licence="http://creativecommons.org/licenses/by/4.0/", xref="doi:10.48539/HBM294.HJJZ.279"} property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:1000322 name: pancreatic goblet cell def: "A goblet cell that is part of the epithelium of pancreatic duct." [GOC:tfm] subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "goblet cell of epithelium of pancreatic duct" EXACT [FMA:263058] xref: FMA:263058 is_a: CL:0000069 ! branched duct epithelial cell is_a: CL:0000160 ! goblet cell is_a: CL:1001599 ! pancreas exocrine glandular cell intersection_of: CL:0000160 ! goblet cell intersection_of: BFO:0000050 UBERON:0001264 ! part of pancreas relationship: BFO:0000050 UBERON:0009970 ! part of epithelium of pancreatic duct property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/2d-ftu/pancreas-pancreatic-acinus/v1.2/assets/2d-ftu-pancreas-pancreatic-acinus.png" xsd:string {terms:licence="http://creativecommons.org/licenses/by/4.0/", xref="doi:10.48539/HBM586.MNXV.276"} property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:1000323 name: pyloric gastric gland goblet cell def: "A goblet cell that is part of the epithelium of pyloric gland." [GOC:tfm] subset: human_subset subset: mouse_subset synonym: "goblet cell of epithelium of pyloric gland" EXACT [] xref: FMA:263061 is_a: CL:0000152 ! exocrine cell is_a: CL:0002659 ! glandular epithelial cell of stomach is_a: CL:1000313 ! gastric goblet cell intersection_of: CL:0000160 ! goblet cell intersection_of: BFO:0000050 UBERON:0008861 ! part of pyloric gastric gland [Term] id: CL:1000324 name: duodenal goblet cell def: "A goblet cell that is part of the epithelium proper of duodenum." [GOC:tfm] subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "goblet cell of epithelium proper of duodenum" EXACT [] xref: FMA:263063 is_a: CL:1000317 ! intestinal villus goblet cell is_a: CL:1001589 ! duodenum secretory cell intersection_of: CL:0000160 ! goblet cell intersection_of: BFO:0000050 UBERON:0008346 ! part of duodenal epithelium property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/2d-ftu/small-intestine-villus/v1.0/assets/2d-ftu-small-intestine-villus.png" xsd:string {terms:licence="http://creativecommons.org/licenses/by/4.0/", xref="doi:10.48539/HBM974.XQDB.889"} property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:1000325 name: jejunal goblet cell def: "A goblet cell that is part of the epithelium proper of jejunum." [GOC:tfm] subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "goblet cell of epithelium proper of jejunum" EXACT [] xref: FMA:263065 is_a: CL:1000317 ! intestinal villus goblet cell intersection_of: CL:0000160 ! goblet cell intersection_of: BFO:0000050 UBERON:0000400 ! part of jejunal epithelium relationship: BFO:0000050 UBERON:0000400 ! part of jejunal epithelium property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:1000326 name: ileal goblet cell def: "A goblet cell that is part of the epithelium proper of ileum." [GOC:tfm] subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "goblet cell of epithelium proper of ileum" EXACT [] xref: FMA:263067 is_a: CL:1000317 ! intestinal villus goblet cell intersection_of: CL:0000160 ! goblet cell intersection_of: BFO:0000050 UBERON:0008345 ! part of ileal epithelium relationship: BFO:0000050 UBERON:0008345 ! part of ileal epithelium property_value: RO:0002175 NCBITaxon:9606 property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_1000326" xsd:string {name="ileal goblet cell on CELLxGENE CellGuide"} property_value: terms:description "The ileal goblet cell is a subset of intestinal goblet cells that are a key component of the epithelium of the ileum, a portion of the small intestine. Goblet cells are named and characterized by their distinctive 'goblet' shape with a narrow base tapering to a broad apical surface; located between the lumen of the intestine and the internal environment of the body, they serve an integral role in maintaining gut homeostasis.\nLike all intestinal goblet cells, the primary function of ileal goblet cells is the production and secretion of mucins, large, heavily glycosylated proteins that combine to form mucus. This mucus lining serves as a protective barrier, shielding the underlying tissue from the potentially damaging effects of digestive enzymes, acids, or pathogenic microbes present in the gut lumen. Their strategic location in the ileal segment of the intestinal tract aids in efficient nutrient absorption while also maintaining an impregnable barrier against potential pathogens, ensuring an intricate balance.\nGoblet cells of the ileum also play a significant role in immune modulation. They are thought to promote oral tolerance (the immune unresponsiveness to orally ingested antigens such as food) by delivering luminal antigens to underlying dendritic cells, thereby driving immune education and tolerogenic responses. They also secrete bioactive molecules, such as the trefoil factor peptide TFF3, which aids in repairing damaged epithelium. By performing these crucial functions, ileal goblet cells not only aid in maintaining intestinal health, but also contribute significantly to the overall well-being of the organism.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1007/s11894-010-0131-2", xref="DOI:10.1038/nature10863", xref="DOI:10.1038/s41575-022-00675-x", xref="DOI:10.1111/imr.12182"} [Term] id: CL:1000327 name: appendix goblet cell def: "A goblet cell that is part of the epithelium proper of appendix." [GOC:tfm] subset: human_subset subset: mouse_subset synonym: "goblet cell of epithelium proper of appendix" EXACT [] xref: FMA:263069 is_a: CL:1000320 ! large intestine goblet cell is_a: CL:1000405 ! epithelial cell of appendix intersection_of: CL:0000160 ! goblet cell intersection_of: BFO:0000050 UBERON:0009697 ! part of epithelium of appendix [Term] id: CL:1000328 name: obsolete goblet cell of epithelium proper of large intestine def: "OBSOLETE: A goblet cell that is part of the epithelium proper of large intestine." [GOC:tfm] xref: FMA:263071 is_obsolete: true [Term] id: CL:1000329 name: tracheal goblet cell def: "A goblet cell that is part of the epithelium of trachea." [GOC:tfm] subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "goblet cell of epithelium of trachea" EXACT [FMA:263075] xref: FMA:263075 is_a: CL:0000307 ! tracheal epithelial cell is_a: CL:0019003 ! tracheobronchial goblet cell intersection_of: CL:0000160 ! goblet cell intersection_of: BFO:0000050 UBERON:0003126 ! part of trachea relationship: BFO:0000050 UBERON:0001901 ! part of epithelium of trachea property_value: RO:0002175 NCBITaxon:9606 property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_1000329" xsd:string {name="tracheal goblet cell on CELLxGENE CellGuide"} property_value: terms:description "Tracheal goblet cells are specialized cells found in the lining of the trachea. They are a key component of the tracheobronchial epithelium, a critical region responsible for maintaining open airways and preventing the ingress of harmful particles or irritants. Goblet cells are filled with membrane-bound secretory granules, which are responsible for their distinctive, goblet-like shape.\nGoblet cells specialize in the production and secretion of mucus, a slimy substance composed primarily of glycoproteins (mucins) and water. This sticky mucus serves to trap foreign particles and pollutants, such as dust, bacteria, and viruses that an organism breathes in. After trapping these particles, the cilia on neighboring ciliated epithelial cells beat synchronously, forming a coordinated escalator to push mucus upwards toward the pharynx, where it's either swallowed or expectorated. This system, known as the mucociliary clearance or escalator, forms a crucial barrier in the lungs against respiratory pathogens and external insults.\nChanges in the number or function of tracheal goblet cells can engender health complications. For example, goblet cell hyperplasia, or excessive growth of goblet cells, is a common feature of chronic inflammatory lung diseases such as asthma and Chronic Obstructive Pulmonary Disease (COPD). This condition results in mucus hypersecretion, airway blockage, and increased risk of respiratory tract infections.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1016/S1357-2725(02)00083-3", xref="DOI:10.1164/ajrccm.154.6.8970383", xref="DOI:10.1165/ajrcmb.25.5.f218", xref="DOI:10.2147/COPD.S38938", xref="DOI:10.3109/01902148.2013.791733"} [Term] id: CL:1000330 name: serous cell of epithelium of trachea def: "A serous secreting cell that is part of the epithelium of trachea." [GOC:tfm] subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset xref: FMA:263078 is_a: CL:0019001 ! tracheobronchial serous cell intersection_of: CL:0000313 ! serous secreting cell intersection_of: BFO:0000050 UBERON:0001901 ! part of epithelium of trachea relationship: BFO:0000050 UBERON:0001901 ! part of epithelium of trachea property_value: RO:0002175 NCBITaxon:9606 property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_1000330" xsd:string {name="serous cell of epithelium of trachea on CELLxGENE CellGuide"} property_value: terms:description "Serous cells are specialized epithelial cells and can be found lining the trachea and brochus. They are among the major components of the respiratory epithelium. \nThese cells are known for their production and release of serous secretions, which form a key component of airway mucus. These secretions primarily comprise of water, proteins, and enzymes, such as lysozyme and peroxidases. Their main purposes are to provide hydration and lubrication to the airway tissue and to act as a defense mechanism against pathogens. While the lysozyme and peroxidases contribute to the destruction of bacteria, the water in the secretions helps to liquefy the mucus, facilitating the effective functioning of the ciliated cells that propel the mucus up the trachea.\nThe coordinated action between serous cells and other cell types in the tracheal epithelium proves essential for maintaining a healthy respiratory tract. Dysfunction or damage of these cells can lead to various respiratory tract disorders, such as cystic fibrosis and asthma.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1002/dvdy.24250", xref="DOI:10.1016/B978-012330215-1/50029-6", xref="DOI:10.1016/S0034-5687(01)00214-", xref="DOI:10.1074/jbc.M208826200"} [Term] id: CL:1000331 name: serous cell of epithelium of bronchus def: "A serous secreting cell that is part of the epithelium of bronchus." [GOC:tfm] subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset xref: FMA:263080 is_a: CL:0019001 ! tracheobronchial serous cell intersection_of: CL:0000313 ! serous secreting cell intersection_of: BFO:0000050 UBERON:0002031 ! part of epithelium of bronchus relationship: BFO:0000050 UBERON:0002031 ! part of epithelium of bronchus property_value: RO:0002175 NCBITaxon:9606 property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_1000331" xsd:string {name="serous cell of epithelium of bronchus on CELLxGENE CellGuide"} property_value: terms:description "Serous cells of the epithelium of the bronchus, also termed bronchial serous cells, are predominantly found within the seromucous glands located in the bronchial submucosa. Serous cells can also be found in the trachea and are characterized by small, sparse, electron-dense granules.\nSerous cells are specialized cells responsible for the production and secretion of serous fluid. Serous fluid, mainly composed of water, proteins, and various types of salts, provides many benefits: it helps moisturize the airways, keep the bronchial tube walls moist, and safeguard the bronchial tubes against various foreign particles and infectious agents such as bacteria and viruses. Moreover, the fluid released by these cells assists in the lubrication and reduced friction in the bronchi, allowing for smoother airflow.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1152/physrev.00039.2014", xref="https://www.ncbi.nlm.nih.gov/books/NBK534789/", xref="https://www.sciencedirect.com/topics/neuroscience/secretory-cell"} [Term] id: CL:1000332 name: serous cell of epithelium of terminal bronchiole def: "A serous secreting cell that is part of the epithelium of terminal bronchiole." [GOC:tfm] subset: human_subset subset: mouse_subset xref: FMA:263082 is_a: CL:0019001 ! tracheobronchial serous cell is_a: CL:1000272 ! lung secretory cell intersection_of: CL:0000313 ! serous secreting cell intersection_of: BFO:0000050 UBERON:0001958 ! part of terminal bronchiole epithelium relationship: BFO:0000050 UBERON:0001958 ! part of terminal bronchiole epithelium [Term] id: CL:1000333 name: serous cell of epithelium of lobular bronchiole def: "A serous secreting cell that is part of the epithelium of bronchiole." [GOC:tfm] subset: cellxgene_subset subset: human_subset subset: mouse_subset xref: FMA:263084 is_a: CL:0019001 ! tracheobronchial serous cell is_a: CL:1000272 ! lung secretory cell intersection_of: CL:0000313 ! serous secreting cell intersection_of: BFO:0000050 UBERON:8600001 ! part of epithelium of lobular bronchiole relationship: BFO:0000050 UBERON:8600001 ! part of epithelium of lobular bronchiole [Term] id: CL:1000334 name: enterocyte of epithelium of small intestine def: "An enterocyte that is part of the epithelium of small intestine." [GOC:tfm] subset: cellxgene_subset subset: human_subset subset: mouse_subset xref: FMA:263086 is_a: CL:0000584 {is_inferred="true"} ! enterocyte is_a: CL:0002254 ! epithelial cell of small intestine intersection_of: CL:0000584 ! enterocyte intersection_of: BFO:0000050 UBERON:0001902 ! part of epithelium of small intestine relationship: BFO:0000050 UBERON:0001902 ! part of epithelium of small intestine property_value: foaf:depiction http://purl.obolibrary.org/obo/cl/images/Small-intestine-cells.png {dc:license="http://creativecommons.org/licenses/by/4.0/", xref="doi:10.1186/s13619-020-00061-5", comment="Figure depicts a cross section of intestinal villi in the small intestine, including the crypts of Lieberkuhn (seen here as ‘crypt’), as well as the layer specific locations of cells that exist within the gastrointestinal tract. Layers depicted here include epithelium (rows of cells bordering villus), submucosa (white space below the epithelium containing networks of neurons and ganglia depicted in pink), muscularis mucosae (blue layer), muscularis propria (referred to here as muscle layer).\n\nISC: Intestinal Stem Cell \nTA: Transit Amplifying Cells"} property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_1000334" xsd:string {name="enterocyte of epithelium of small intestine on CELLxGENE CellGuide"} property_value: terms:description "Enterocytes of the epithelium of the small intestine are specialized cells that reside in the lining of the small intestine, and are primarily responsible for the essential process of nutrient absorption. These cells are columnar epithelial cells with an apical surface lined with microvilli, a feature referred to as the 'brush border', to maximize the surface area available for absorption.\nEnterocytes play a critical role in both the digestion and absorption of nutrients from food. Their extensive brush border contains enzymes that further assist in nutrient breakdown and transport proteins that transfer nutrients, such as glucose, amino acids, lipids, and vitamins, across the cell membrane. \nThe enterocytes of the small intestine also participate in the barrier function of the gut lining. Enterocytes are connected by tight junctions, which act as a primary defense line against pathogenic invasion by maintaining intestinal barrier integrity. Additionally, their cell surface is coated in glycocalyx and mucus which forms a defensive barrier preventing the penetration of harmful bacteria into the systemic circulation.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1038/nrgastro.2013.35", xref="DOI:10.1038/nri3738", xref="DOI:10.1084/jem.20191130", xref="DOI:10.3389/fphys.2021.699152/full"} [Term] id: CL:1000335 name: enterocyte of epithelium of intestinal villus def: "An enterocyte that is part of the epithelium of intestinal villus." [GOC:tfm] subset: human_subset subset: mouse_subset xref: FMA:263088 is_a: CL:1000334 ! enterocyte of epithelium of small intestine intersection_of: CL:0000584 ! enterocyte intersection_of: BFO:0000050 UBERON:0013636 ! part of epithelium of intestinal villus relationship: BFO:0000050 UBERON:0013636 ! part of epithelium of intestinal villus [Term] id: CL:1000337 name: enterocyte of epithelium of duodenal gland def: "An enterocyte that is part of the epithelium of duodenal gland." [GOC:tfm] subset: human_subset subset: mouse_subset xref: FMA:263092 is_a: CL:1000334 ! enterocyte of epithelium of small intestine intersection_of: CL:0000584 ! enterocyte intersection_of: BFO:0000050 UBERON:0001212 ! part of duodenal gland relationship: BFO:0000050 UBERON:0001212 ! part of duodenal gland [Term] id: CL:1000338 name: enterocyte of epithelium of crypt of Lieberkuhn of small intestine def: "An enterocyte that is part of the epithelium of crypt of Lieberkuhn of small intestine." [GOC:tfm] subset: human_subset subset: mouse_subset xref: FMA:263094 is_a: CL:1000334 ! enterocyte of epithelium of small intestine relationship: BFO:0000050 UBERON:0001983 ! part of crypt of Lieberkuhn [Term] id: CL:1000339 name: enterocyte of epithelium proper of small intestine def: "An enterocyte that is part of the epithelium proper of small intestine." [GOC:tfm] subset: cellxgene_subset subset: human_subset subset: mouse_subset xref: FMA:263096 is_a: CL:1000334 ! enterocyte of epithelium of small intestine [Term] id: CL:1000340 name: enterocyte of epithelium proper of duodenum def: "An enterocyte that is part of the epithelium proper of duodenum." [GOC:tfm] subset: cellxgene_subset subset: human_subset subset: mouse_subset xref: FMA:263098 is_a: CL:1000339 ! enterocyte of epithelium proper of small intestine relationship: BFO:0000050 UBERON:0002114 ! part of duodenum [Term] id: CL:1000341 name: enterocyte of epithelium proper of jejunum def: "An enterocyte that is part of the epithelium proper of jejunum." [GOC:tfm] subset: cellxgene_subset subset: human_subset subset: mouse_subset xref: FMA:263100 is_a: CL:1000339 ! enterocyte of epithelium proper of small intestine [Term] id: CL:1000342 name: enterocyte of epithelium proper of ileum def: "An enterocyte that is part of the epithelium proper of ileum." [GOC:tfm] subset: cellxgene_subset subset: human_subset subset: mouse_subset xref: FMA:263102 is_a: CL:1000339 ! enterocyte of epithelium proper of small intestine property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_1000342" xsd:string {name="enterocyte of epithelium proper of ileum on CELLxGENE CellGuide"} property_value: terms:description "Enterocytes of the epithelium proper of the ileum, commonly known as ileal enterocytes, are specialized epithelial cells found lining the inner surface of the ileum, the final section of the small intestine in the human body. They play a pivotal role in nutrient absorption, digestive metabolic functions, and the maintenance of the host’s immune response. \nLike enterocytes in other parts of the intestine, ileal enterocytes exhibit distinct characteristics specific to their function and role. They have microvilli on their apical surfaces to increase absorption and are important in the absorption of vitamins and the reabsorption of bile salts. These cells also produce enzymes that metabolize lipids and xenobiotics.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1038/nri3738", xref="DOI:10.1084/jem.20191130", xref="DOI:10.1111/j.1365-2249.2011.04523.x"} [Term] id: CL:1000343 name: paneth cell of epithelium of small intestine def: "A paneth cell that is part of the epithelium of small intestine." [GOC:tfm] subset: cellxgene_subset subset: human_subset subset: mouse_subset xref: FMA:263104 is_a: CL:0000510 {is_inferred="true"} ! paneth cell is_a: CL:1001598 ! small intestine secretory cell intersection_of: CL:0000510 ! paneth cell intersection_of: BFO:0000050 UBERON:0001902 ! part of epithelium of small intestine property_value: foaf:depiction http://purl.obolibrary.org/obo/cl/images/Small-intestine-cells.png {dc:license="http://creativecommons.org/licenses/by/4.0/", xref="doi:10.1186/s13619-020-00061-5", comment="Figure depicts a cross section of intestinal villi in the small intestine , including the crypts of Lieberkuhn (seen here as ‘crypt’), as well as the layer specific locations of cells that exist within the gastrointestinal tract. Layers depicted here include epithelium (rows of cells bordering villus), submucosa (white space below the epithelium containing networks of neurons and ganglia depicted in pink), muscularis mucosae (blue layer), muscularis propria (referred to here as muscle layer).\n\nISC: Intestinal Stem Cell \nTA: Transit Amplifying Cells"} property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_1000343" xsd:string {name="paneth cell of epithelium of small intestine on CELLxGENE CellGuide"} property_value: terms:description "Paneth cells of the epithelium of the small intestine, often referred to simply as Paneth cells, are a type of specialized secretory cell that forms an integral part of the intestinal crypts of Lieberkühn – gland-like invaginations lining the small intestine. Named after the Austrian physician Josef Paneth, who first identified them in the late 19th century, these cells are significant because of their substantial involvement in the mucosal immune system and intestinal stem cell maintenance.\nFunctionally, Paneth cells play a key role in maintaining gut homeostasis and in the first line of antimicrobial defense, mainly through the secretion of a range of antimicrobial peptides and proteins. These include lysozymes, cryptdins, or alpha-defensins, which have potent activity against various gut pathogens including bacteria, fungi, and parasites. Furthermore, Paneth cells of the small intestine are also known to release secretory phospholipase A2, an enzyme active against gram-positive bacteria. Additionally, they secrete several growth factors like EGF, TGF-alpha, and Wnt3, which are crucial for stem cell support and the overall maintenance of intestinal mucosal integrity.\nThe unique location of Paneth cells at the base of the crypts positions them in very close proximity to intestinal stem cells. This not only facilitates their role in stem cell maintenance but also involves them in epithelial regeneration and repair following injury. Dysfunctional Paneth cells have been associated with several gut disorders, like Crohn’s disease and necrotizing enterocolitis.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1007/s00018-002-8412-z", xref="DOI:10.1038/nature09637", xref="DOI:10.1038/nrmicro2546", xref="DOI:10.1146/annurev-physiol-030212-183744", xref="DOI:10.3389/fimmu.2020.00587"} [Term] id: CL:1000344 name: paneth cell of epithelium proper of small intestine def: "A Paneth cell that is part of the epithelium proper of small intestine." [GOC:tfm] subset: human_reference_atlas subset: human_subset subset: mouse_subset xref: FMA:263106 is_a: CL:1000343 ! paneth cell of epithelium of small intestine property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:1000345 name: paneth cell of epithelium of crypt of Lieberkuhn of small intestine def: "A paneth cell that is part of the epithelium of crypt of Lieberkuhn of small intestine." [GOC:tfm] subset: human_subset subset: mouse_subset xref: FMA:263108 is_a: CL:1000343 ! paneth cell of epithelium of small intestine [Term] id: CL:1000346 name: enterocyte of epithelium proper of large intestine alt_id: CL:1000336 def: "An enterocyte that is part of the epithelium proper of large intestine." [GOC:tfm] subset: human_subset subset: mouse_subset synonym: "vacuolar absorptive cell of epithelium proper of large intestine" NARROW [] xref: FMA:263090 xref: FMA:263112 is_a: CL:0002071 ! enterocyte of epithelium of large intestine [Term] id: CL:1000347 name: colonocyte def: "An enterocyte (absorptive epithelial cell) of the colonic epithelium, characterized by a columnar shape. This cell is responsible for the absorption, transport, and metabolization of short-chain fatty acids (SCFAs) produced by gut bacteria, as well as the transport and absorption of water and electrolytes." [GOC:tfm, PMID:16870803, PMID:23821742, PMID:34497389] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "enterocyte of colon" EXACT [] synonym: "vacuolar absorptive cell of epithelium of colon" NARROW [] xref: FMA:263114 is_a: CL:0002071 ! enterocyte of epithelium of large intestine is_a: CL:0011108 ! colon epithelial cell intersection_of: CL:0002071 ! enterocyte of epithelium of large intestine intersection_of: BFO:0000050 UBERON:0000397 ! part of colonic epithelium relationship: RO:0002215 GO:0019626 ! capable of short-chain fatty acid catabolic process relationship: RO:0002215 GO:0035377 ! capable of transepithelial water transport property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_1000347" xsd:string {name="colonocyte on CELLxGENE CellGuide"} property_value: terms:description "Enterocytes of the colon are specialized epithelial cells located in the lining of the colon, the largest part of the large intestine. These cells play a critical role in absorbing water, electrolytes, and certain vitamins from the food material passed on from the small intestine. With a unique structure of finger-like protrusions referred to as microvilli, the enterocytes increase their surface area for effective absorption. The colon is the last part of the digestive system, and as such, it is responsible for compacting undigested food materials and forming fecal matter. Enterocytes of the colon facilitate this process effectively through absorption of water.\nEnterocytes are known for their high regeneration potential, replenishing every 4-5 days, enabling the healthy functioning of the colon. They originate from stem cells located in the crypt of the colon and differentiate into mature enterocytes as they migrate upwards towards the luminal surface. This constant turnover aids in maintaining the intestinal barrier, preventing the entry of detrimental substances into the systemic circulation. Their tight junctions with other epithelial cells provide a robust barrier against invasive pathogens.\nEnterocytes of the colon are involved in the communication with the gut microbiota. These cells harbor enzymes necessary for the metabolism of short-chain fatty acids, which are the byproducts of the fermentation process by gut bacteria. Short-chain fatty acids serve as a major energy source for colonocytes and are important for maintaining colonic health. The dysfunction of enterocytes, therefore, could lead to disorders such as inflammatory bowel disease or colorectal cancer.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1007/s11894-010-0130-3", xref="DOI:10.1038/nrgastro.2013.35", xref="DOI:10.1038/nri3738", xref="DOI:10.1084/jem.20191130", xref="DOI:10.3389/fimmu.2019.00277"} [Term] id: CL:1000348 name: basal cell of epithelium of trachea def: "A basal cell that is part of the epithelium of trachea." [GOC:tfm] subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset xref: FMA:263118 is_a: CL:0002633 {is_inferred="true"} ! respiratory basal cell intersection_of: CL:0002633 ! respiratory basal cell intersection_of: BFO:0000050 UBERON:0001901 ! part of epithelium of trachea relationship: BFO:0000050 UBERON:0001901 ! part of epithelium of trachea property_value: RO:0002175 NCBITaxon:9606 property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_1000348" xsd:string {name="basal cell of epithelium of trachea on CELLxGENE CellGuide"} property_value: terms:description "Basal cells of epithelium of trachea are a vital cell population within the respiratory tract's lining, specifically in the trachea's epithelium. These cells are located at the base of the columnar epithelial cell layer and can be identified by their characteristic cuboidal shape, a large nucleus and few organelles, as well as scattered microvilli. The basal cells are not in direct contact with the lumen, which is covered by a layer of ciliated and non-ciliated columnar cells. Instead, the basal cells are connected to, and line, a thin basement membrane.\nThe primary function of basal cells involves stem cell activity and epithelial tissue maintenance. Basal cells in the trachea play a crucial role in the regeneration and repair of the tracheal epithelium during damage or injury, acting as progenitor cells for ciliated and secretory cells. They serve as a reserve pool of cells, ready to proliferate and differentiate as needed for homeostatic tissue maintenance or in repair processes when the epithelium has been compromised, whether by injury or disease.\nThese cells are also implicated in numerous disease pathways. Conditions like chronic obstructive pulmonary disease and lung cancer exhibit unusual behavior and quantities of tracheal basal cells, making these cells a focal point in respiratory disease research. In summary, basal cells in the tracheal epithelium have a multifaceted role in maintaining, repairing, and influencing tracheal health, playing a crucial role in the stability of the respiratory system.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1164/rccm.201408-1492PP", xref="DOI:10.1165/rcmb.2021-0150ED", xref="DOI:10.1242/dmm.006031", xref="DOI:10.3389/falgy.2021.787128"} [Term] id: CL:1000349 name: basal cell of epithelium of bronchus alt_id: CL:0002331 def: "A basal cell found in the bronchus epithelium." [GOC:tfm] subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "basal cell of bronchus" EXACT [] xref: FMA:263120 is_a: CL:0002328 ! bronchial epithelial cell is_a: CL:0002329 ! basal epithelial cell of tracheobronchial tree is_a: CL:0002633 ! respiratory basal cell intersection_of: CL:0002633 ! respiratory basal cell intersection_of: BFO:0000050 UBERON:0002031 ! part of epithelium of bronchus property_value: RO:0002175 NCBITaxon:9606 property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_1000349" xsd:string {name="basal cell of epithelium of bronchus on CELLxGENE CellGuide"} property_value: terms:description "The basal cells of the epithelium of the bronchus are a vital component of the cellular linings found within the bronchial tubes of the respiratory system. They are typically nonciliated, cuboidal cells that are tightly attached to the basement membrane, thereby providing structural support for the epithelial tissues. \nThe function of the basal cell of the bronchial epithelium is multifaceted, underscoring the importance of these cells for respiratory health. One of their primary roles involves regeneration and cellular turnover. They serve as local stem cells, being able to proliferate and differentiate into other cell types such as ciliated and secretory epithelial cells. This regenerative function of basal cells is required for maintaining the integrity of the bronchial epithelium and is especially critical after injury or during disease states when there is an increased need for new cells to repair damaged tissue or replace lost cells. \nIn addition to these regenerative duties, basal cells of the bronchial epithelium play a crucial role in providing a defensive barrier against inhaled substances. They participate in the coordinated immune response directed against airborne pathogens, foreign particles, and toxins that enter the respiratory tract. Basal cells can respond to inflammation or irritation by altering their activities, which include proliferating, differentiating, or producing bioactive substances. Throughout all these responses, the basal cells help to maintain the homeostasis of the bronchial tubes, allowing for the efficient transport of air to and from the lungs.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1002/ar.1092380310", xref="DOI:10.1038/labinvest.2015.114", xref="DOI:10.1136/thx.2004.la0104", xref="DOI:10.3389/falgy.2021.787128"} [Term] id: CL:1000350 name: basal cell of epithelium of terminal bronchiole def: "A basal cell that is part of the epithelium of terminal bronchiole." [GOC:tfm] subset: human_reference_atlas subset: human_subset subset: mouse_subset xref: FMA:263122 is_a: CL:0002633 {is_inferred="true"} ! respiratory basal cell intersection_of: CL:0002633 ! respiratory basal cell intersection_of: BFO:0000050 UBERON:0001958 ! part of terminal bronchiole epithelium relationship: BFO:0000050 UBERON:0001958 ! part of terminal bronchiole epithelium property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:1000351 name: basal cell of epithelium of respiratory bronchiole def: "A basal cell that is part of the epithelium of respiratory bronchiole." [GOC:tfm] subset: human_reference_atlas subset: human_subset subset: mouse_subset xref: FMA:263124 is_a: CL:0002633 {is_inferred="true"} ! respiratory basal cell intersection_of: CL:0002633 ! respiratory basal cell intersection_of: BFO:0000050 UBERON:0001955 ! part of epithelium of respiratory bronchiole relationship: BFO:0000050 UBERON:0001955 ! part of epithelium of respiratory bronchiole property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:1000352 name: basal cell of epithelium of lobular bronchiole def: "A basal cell that is part of the epithelium of bronchiole." [GOC:tfm] subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset xref: FMA:263126 is_a: CL:0002633 {is_inferred="true"} ! respiratory basal cell intersection_of: CL:0002633 ! respiratory basal cell intersection_of: BFO:0000050 UBERON:8600001 ! part of epithelium of lobular bronchiole relationship: BFO:0000050 UBERON:8600001 ! part of epithelium of lobular bronchiole property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:1000353 name: microfold cell of epithelium of small intestine def: "A M cell that is part of the epithelium of small intestine." [GOC:tfm] subset: cellxgene_subset subset: human_subset subset: mouse_subset xref: FMA:263128 is_a: CL:0000682 {is_inferred="true"} ! M cell of gut is_a: CL:0002254 ! epithelial cell of small intestine intersection_of: CL:0000682 ! M cell of gut intersection_of: BFO:0000050 UBERON:0002108 ! part of small intestine relationship: BFO:0000050 UBERON:0001902 ! part of epithelium of small intestine property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_1000353" xsd:string {name="microfold cell of epithelium of small intestine on CELLxGENE CellGuide"} property_value: terms:description "Microfold cells, also widely known as M cells, are a distinct type of epithelial cell found in the gut, including the small intestine, specifically within the Peyer’s patches, a component of the gut-associated lymphoid tissue (GALT). M cells play a crucial role in the immune response within the intestine environment. \nThese cells are characterized by microfolds (short microvilli, which give them their name), a reduced, thin glycocalyx, and a deeply invaginated basolateral membrane next to immune cells such as B cells, T cells, and macrophages, and DCs. \nThese features allow the M cells to form the first point of contact between the gut lumen and the intestinal immune system. They are well-regulated gateways that capture and transport antigens, such as bacteria, viruses, and other foreign substances found in the lumen, to the underlying cells of the immune system. This specialized transport mechanism, called ‘transcytosis’, involves engulfment of these antigens from the apical side, transport across their cytoplasm, and release on the basolateral side of the cells, where immune responses can be initiated. \nFurthermore, M cells have complex interactions with members of the gut microbiota and other immune cells, making them essential for maintaining gut homeostasis. This cross-talk shapes the diversity and makeup of the gut microbiota, subsequently having a substantial impact on the host's health. In certain situations, pathogenic organisms can exploit the transcytosis mechanism to infiltrate the host's system, causing various infectious diseases.\nThe overarching significance of M cells in the small intestine lies in their role of surveillance and protection against a wide range of potentially harmful pathogens, while also facilitating beneficial interactions with commensal microbes.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1038/mi.2013.30", xref="DOI:10.1093/jb/mvv121", xref="DOI:10.1111/j.1574-695X.2007.00359.x", xref="DOI:10.3389/fimmu.2019.01499"} [Term] id: CL:1000354 name: microfold cell of epithelium of intestinal villus def: "A M cell that is part of the epithelium of intestinal villus." [GOC:tfm] subset: human_subset subset: mouse_subset xref: FMA:263130 is_a: CL:1000353 ! microfold cell of epithelium of small intestine intersection_of: CL:0000682 ! M cell of gut intersection_of: BFO:0000050 UBERON:0001213 ! part of intestinal villus relationship: BFO:0000050 UBERON:0013636 ! part of epithelium of intestinal villus [Term] id: CL:1000355 name: microfold cell of epithelium proper of small intestine def: "A M cell that is part of the epithelium proper of small intestine." [GOC:tfm] subset: human_subset subset: mouse_subset xref: FMA:263132 is_a: CL:1000353 ! microfold cell of epithelium of small intestine [Term] id: CL:1000356 name: microfold cell of epithelium proper of duodenum def: "A M cell that is part of the epithelium proper of duodenum." [GOC:tfm] subset: human_subset subset: mouse_subset xref: FMA:263134 is_a: CL:1000354 ! microfold cell of epithelium of intestinal villus intersection_of: CL:0000682 ! M cell of gut intersection_of: BFO:0000050 UBERON:0002114 ! part of duodenum relationship: BFO:0000050 UBERON:0008346 ! part of duodenal epithelium [Term] id: CL:1000357 name: microfold cell of epithelium proper of jejunum def: "A M cell that is part of the epithelium proper of jejunum." [GOC:tfm] subset: human_subset subset: mouse_subset xref: FMA:263136 is_a: CL:1000353 ! microfold cell of epithelium of small intestine intersection_of: CL:0000682 ! M cell of gut intersection_of: BFO:0000050 UBERON:0002115 ! part of jejunum relationship: BFO:0000050 UBERON:0002115 ! part of jejunum [Term] id: CL:1000358 name: microfold cell of epithelium proper of ileum def: "A M cell that is part of the epithelium proper of ileum." [GOC:tfm] subset: human_subset subset: mouse_subset xref: FMA:263138 is_a: CL:1000353 ! microfold cell of epithelium of small intestine intersection_of: CL:0000682 ! M cell of gut intersection_of: BFO:0000050 UBERON:0002116 ! part of ileum relationship: BFO:0000050 UBERON:0002116 ! part of ileum [Term] id: CL:1000359 name: microfold cell of epithelium proper of appendix def: "A M cell that is part of the epithelium proper of appendix." [GOC:tfm] subset: human_subset subset: mouse_subset xref: FMA:263140 is_a: CL:1000360 ! microfold cell of epithelium proper of large intestine is_a: CL:1000405 ! epithelial cell of appendix intersection_of: CL:0000682 ! M cell of gut intersection_of: BFO:0000050 UBERON:0001154 ! part of vermiform appendix [Term] id: CL:1000360 name: microfold cell of epithelium proper of large intestine def: "A M cell that is part of the epithelium proper of large intestine." [GOC:tfm] subset: human_subset subset: mouse_subset xref: FMA:263142 is_a: CL:0000682 ! M cell of gut is_a: CL:0002253 ! epithelial cell of large intestine intersection_of: CL:0000682 ! M cell of gut intersection_of: BFO:0000050 UBERON:0000059 ! part of large intestine [Term] id: CL:1000361 name: transitional myocyte of interatrial septum def: "A transitional myocyte that is part of the interatrial septum." [GOC:tfm] subset: human_subset subset: mouse_subset xref: FMA:263152 is_a: CL:0002073 {is_inferred="true"} ! transitional myocyte is_a: CL:2000022 ! cardiac septum cell intersection_of: CL:0002073 ! transitional myocyte intersection_of: BFO:0000050 UBERON:0002085 ! part of interatrial septum relationship: BFO:0000050 UBERON:0002085 ! part of interatrial septum [Term] id: CL:1000362 name: transitional myocyte of interventricular septum def: "A transitional myocyte that is part of the interventricular septum." [GOC:tfm] subset: human_subset subset: mouse_subset xref: FMA:263154 is_a: CL:0002073 {is_inferred="true"} ! transitional myocyte is_a: CL:2000022 ! cardiac septum cell intersection_of: CL:0002073 ! transitional myocyte intersection_of: BFO:0000050 UBERON:0002094 ! part of interventricular septum relationship: BFO:0000050 UBERON:0002094 ! part of interventricular septum [Term] id: CL:1000363 name: transitional myocyte of atrial branch of anterior internodal tract def: "A transitional myocyte that is part of the atrial branch of anterior internodal tract." [GOC:tfm] subset: human_subset subset: mouse_subset xref: FMA:263156 is_a: CL:1000480 ! transitional myocyte of internodal tract [Term] id: CL:1000364 name: transitional myocyte of anterior internodal tract def: "A transitional myocyte that is part of the anterior internodal tract." [GOC:tfm] subset: human_subset subset: mouse_subset xref: FMA:263158 is_a: CL:1000480 ! transitional myocyte of internodal tract [Term] id: CL:1000365 name: transitional myocyte of atrial septal branch of anterior internodal tract def: "A transitional myocyte that is part of the atrial septal branch of anterior internodal tract." [GOC:tfm] subset: human_subset subset: mouse_subset xref: FMA:263160 is_a: CL:1000480 ! transitional myocyte of internodal tract [Term] id: CL:1000366 name: transitional myocyte of middle internodal tract def: "A transitional myocyte that is part of the middle internodal tract." [GOC:tfm] subset: human_subset subset: mouse_subset xref: FMA:263162 is_a: CL:1000480 ! transitional myocyte of internodal tract [Term] id: CL:1000367 name: transitional myocyte of posterior internodal tract def: "A transitional myocyte that is part of the posterior internodal tract." [GOC:tfm] subset: human_subset subset: mouse_subset xref: FMA:263164 is_a: CL:1000480 ! transitional myocyte of internodal tract [Term] id: CL:1000368 name: transitional myocyte of anterior division of left branch of atrioventricular bundle def: "A transitional myocyte that is part of the anterior division of left branch of atrioventricular bundle." [GOC:tfm] subset: human_subset subset: mouse_subset xref: FMA:263166 is_a: CL:1000370 ! transitional myocyte of left branch of atrioventricular bundle [Term] id: CL:1000369 name: transitional myocyte of septal division of left branch of atrioventricular bundle def: "A transitional myocyte that is part of the septal division of left branch of atrioventricular bundle." [GOC:tfm] subset: human_subset subset: mouse_subset xref: FMA:263168 is_a: CL:1000370 ! transitional myocyte of left branch of atrioventricular bundle [Term] id: CL:1000370 name: transitional myocyte of left branch of atrioventricular bundle def: "A transitional myocyte that is part of the left branch of atrioventricular bundle." [GOC:tfm] subset: human_subset subset: mouse_subset xref: FMA:263170 is_a: CL:1000481 ! transitional myocyte of atrioventricular bundle intersection_of: CL:0002073 ! transitional myocyte intersection_of: BFO:0000050 UBERON:0005986 ! part of left bundle branch relationship: BFO:0000050 UBERON:0005986 ! part of left bundle branch [Term] id: CL:1000371 name: transitional myocyte of right branch of atrioventricular bundle def: "A transitional myocyte that is part of the right branch of atrioventricular bundle." [GOC:tfm] subset: human_subset subset: mouse_subset xref: FMA:263172 is_a: CL:1000481 ! transitional myocyte of atrioventricular bundle intersection_of: CL:0002073 ! transitional myocyte intersection_of: BFO:0000050 UBERON:0005987 ! part of right bundle branch relationship: BFO:0000050 UBERON:0005987 ! part of right bundle branch [Term] id: CL:1000372 name: transitional myocyte of atrial part of atrioventricular bundle def: "A transitional myocyte that is part of the atrial part of atrioventricular bundle." [GOC:tfm] subset: human_subset subset: mouse_subset xref: FMA:263174 is_a: CL:1000481 ! transitional myocyte of atrioventricular bundle [Term] id: CL:1000373 name: transitional myocyte of ventricular part of atrioventricular bundle def: "A transitional myocyte that is part of the ventricular part of atrioventricular bundle." [GOC:tfm] subset: human_subset subset: mouse_subset xref: FMA:263176 is_a: CL:1000481 ! transitional myocyte of atrioventricular bundle [Term] id: CL:1000374 name: transitional myocyte of posterior division of left branch of atrioventricular bundle def: "A transitional myocyte that is part of the posterior division of left branch of atrioventricular bundle." [GOC:tfm] subset: human_subset subset: mouse_subset xref: FMA:263178 is_a: CL:1000370 ! transitional myocyte of left branch of atrioventricular bundle [Term] id: CL:1000375 name: myocardial endocrine cell of septal division of left branch of atrioventricular bundle def: "A myocardial endocrine cell that is part of the septal division of left branch of atrioventricular bundle." [GOC:tfm] subset: human_subset subset: mouse_subset xref: FMA:263180 is_a: CL:0002074 ! myocardial endocrine cell is_a: CL:0008009 ! transversely striated visceral muscle cell is_a: CL:2000046 ! ventricular cardiac muscle cell relationship: BFO:0000050 UBERON:0005986 ! part of left bundle branch [Term] id: CL:1000376 name: Purkinje myocyte of interventricular septum def: "A Purkinje myocyte that is part of the interventricular septum." [GOC:tfm] subset: human_subset subset: mouse_subset xref: FMA:263182 is_a: CL:0002068 {is_inferred="true"} ! Purkinje myocyte is_a: CL:2000022 ! cardiac septum cell intersection_of: CL:0002068 ! Purkinje myocyte intersection_of: BFO:0000050 UBERON:0002094 ! part of interventricular septum relationship: BFO:0000050 UBERON:0002094 ! part of interventricular septum [Term] id: CL:1000377 name: dense-core granulated cell of epithelium of trachea def: "A Feyrter cell that is part of the epithelium of trachea." [GOC:tfm] subset: human_subset subset: mouse_subset xref: FMA:263184 is_a: CL:0000307 {is_inferred="true"} ! tracheal epithelial cell is_a: CL:0002066 {is_inferred="true"} ! Feyrter cell is_a: CL:0008055 ! respiratory tract secretory epithelial cell intersection_of: CL:0002066 ! Feyrter cell intersection_of: BFO:0000050 UBERON:0001901 ! part of epithelium of trachea relationship: BFO:0000050 UBERON:0001901 ! part of epithelium of trachea [Term] id: CL:1000378 name: type 1 vestibular sensory cell of stato-acoustic epithelium def: "A type I vestibular sensory cell that is part of the stato-acoustic epithelium." [GOC:tfm] subset: human_subset subset: mouse_subset xref: FMA:263186 is_a: CL:0002070 ! type I vestibular sensory cell is_a: CL:3000004 ! peripheral sensory neuron intersection_of: CL:0002070 ! type I vestibular sensory cell intersection_of: BFO:0000050 UBERON:0009969 ! part of statoacoustic epithelium relationship: BFO:0000050 UBERON:0009969 ! part of statoacoustic epithelium [Term] id: CL:1000379 name: type 1 vestibular sensory cell of epithelium of macula of utricle of membranous labyrinth def: "A type I vestibular sensory cell that is part of the epithelium of macula of utricle of membranous labyrinth." [GOC:tfm] subset: human_subset subset: mouse_subset xref: FMA:263188 is_a: CL:0002070 ! type I vestibular sensory cell is_a: CL:3000004 ! peripheral sensory neuron intersection_of: CL:0002070 ! type I vestibular sensory cell intersection_of: BFO:0000050 UBERON:0002214 ! part of macula of utricle of membranous labyrinth relationship: BFO:0000050 UBERON:0003241 ! part of epithelium of utricle [Term] id: CL:1000380 name: type 1 vestibular sensory cell of epithelium of macula of saccule of membranous labyrinth def: "A type I vestibular sensory cell that is part of the epithelium of macula of saccule of membranous labyrinth." [GOC:tfm] subset: human_subset subset: mouse_subset xref: FMA:263190 is_a: CL:0002070 ! type I vestibular sensory cell is_a: CL:3000004 ! peripheral sensory neuron intersection_of: CL:0002070 ! type I vestibular sensory cell intersection_of: BFO:0000050 UBERON:0002212 ! part of macula of saccule of membranous labyrinth relationship: BFO:0000050 UBERON:0002212 ! part of macula of saccule of membranous labyrinth relationship: BFO:0000050 UBERON:0003242 ! part of epithelium of saccule [Term] id: CL:1000381 name: type 1 vestibular sensory cell of epithelium of crista of ampulla of semicircular duct of membranous labyrinth def: "A type I vestibular sensory cell that is part of the epithelium of crista of ampulla of semicircular duct of membranous labyrinth." [GOC:tfm] subset: human_subset subset: mouse_subset xref: FMA:263192 is_a: CL:0002070 ! type I vestibular sensory cell is_a: CL:3000004 ! peripheral sensory neuron intersection_of: CL:0002070 ! type I vestibular sensory cell intersection_of: BFO:0000050 UBERON:0006935 ! part of crista ampullaris neuroepithelium relationship: BFO:0000050 UBERON:0006935 ! part of crista ampullaris neuroepithelium [Term] id: CL:1000382 name: type 2 vestibular sensory cell of stato-acoustic epithelium def: "A type II vestibular sensory cell that is part of the stato-acoustic epithelium." [GOC:tfm] subset: human_subset subset: mouse_subset xref: FMA:263194 is_a: CL:0002069 ! type II vestibular sensory cell is_a: CL:3000004 ! peripheral sensory neuron intersection_of: CL:0002069 ! type II vestibular sensory cell intersection_of: BFO:0000050 UBERON:0009969 ! part of statoacoustic epithelium relationship: BFO:0000050 UBERON:0009969 ! part of statoacoustic epithelium [Term] id: CL:1000383 name: type 2 vestibular sensory cell of epithelium of macula of utricle of membranous labyrinth def: "A type II vestibular sensory cell that is part of the epithelium of macula of utricle of membranous labyrinth." [GOC:tfm] subset: human_subset subset: mouse_subset xref: FMA:263196 is_a: CL:0002069 ! type II vestibular sensory cell is_a: CL:3000004 ! peripheral sensory neuron intersection_of: CL:0002069 ! type II vestibular sensory cell intersection_of: BFO:0000050 UBERON:0002214 ! part of macula of utricle of membranous labyrinth relationship: BFO:0000050 UBERON:0003241 ! part of epithelium of utricle [Term] id: CL:1000384 name: type 2 vestibular sensory cell of epithelium of macula of saccule of membranous labyrinth def: "A type II vestibular sensory cell that is part of the epithelium of macula of saccule of membranous labyrinth." [GOC:tfm] subset: human_subset subset: mouse_subset xref: FMA:263198 is_a: CL:0002069 ! type II vestibular sensory cell is_a: CL:3000004 ! peripheral sensory neuron intersection_of: CL:0002069 ! type II vestibular sensory cell intersection_of: BFO:0000050 UBERON:0002212 ! part of macula of saccule of membranous labyrinth relationship: BFO:0000050 UBERON:0002212 ! part of macula of saccule of membranous labyrinth relationship: BFO:0000050 UBERON:0003242 ! part of epithelium of saccule [Term] id: CL:1000385 name: type 2 vestibular sensory cell of epithelium of crista of ampulla of semicircular duct of membranous labyrinth def: "A type II vestibular sensory cell that is part of the epithelium of crista of ampulla of semicircular duct of membranous labyrinth." [GOC:tfm] subset: human_subset subset: mouse_subset xref: FMA:263200 is_a: CL:0002069 ! type II vestibular sensory cell is_a: CL:3000004 ! peripheral sensory neuron intersection_of: CL:0002069 ! type II vestibular sensory cell intersection_of: BFO:0000050 UBERON:0006935 ! part of crista ampullaris neuroepithelium relationship: BFO:0000050 UBERON:0006935 ! part of crista ampullaris neuroepithelium [Term] id: CL:1000391 name: melanocyte of eyelid def: "A melanocyte that is part of the eyelid." [GOC:tfm] subset: human_subset subset: mouse_subset synonym: "eyelid melanocyte" EXACT [FMA:59175] synonym: "sebaceous gland of wolff" EXACT [FMA:59175] xref: FMA:59175 is_a: CL:0000148 {is_inferred="true"} ! melanocyte intersection_of: CL:0000148 ! melanocyte intersection_of: BFO:0000050 UBERON:0001711 ! part of eyelid relationship: BFO:0000050 UBERON:0001711 ! part of eyelid [Term] id: CL:1000394 name: myoepithelial cell of intralobular lactiferous duct def: "A myoepithelial cell that is part of the intralobular part of terminal lactiferous duct." [GOC:tfm] subset: human_subset subset: mouse_subset xref: FMA:62158 is_a: CL:0000185 ! myoepithelial cell [Term] id: CL:1000397 name: endothelial cell of venous sinus of red pulp of spleen def: "An endothelial cell that is part of the venous sinus of red pulp of spleen." [GOC:tfm] comment: todo - add logical definition to UBERON:0009967 subset: human_subset subset: mouse_subset xref: FMA:62817 is_a: CL:0002651 ! endothelial cell of venous sinus of spleen is_a: CL:2000053 ! splenic endothelial cell intersection_of: CL:0000115 ! endothelial cell intersection_of: BFO:0000050 UBERON:0009967 ! part of spleen venous sinus relationship: BFO:0000050 UBERON:0009967 ! part of spleen venous sinus [Term] id: CL:1000398 name: endothelial cell of hepatic sinusoid def: "An endothelial cell that is part of the hepatic sinusoid. These cells possess flattened areas containing perforations about 0.1 micrometers in diameter, known as fenestrae. The fenestrae are arranged in groups known as sieve plates." [GOC:tfm, PMID:3926620] subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "endotheliocyte of hepatic sinusoid" EXACT [FMA:62911] synonym: "liver sinusoidal endothelial cell" EXACT [PMID:30348985] synonym: "LSEC" EXACT [PMID:30348985] xref: BTO:000125 xref: FMA:62911 is_a: CL:0000666 ! fenestrated endothelial cell is_a: CL:0002262 ! endothelial cell of sinusoid intersection_of: CL:0000115 ! endothelial cell intersection_of: BFO:0000050 UBERON:0001281 ! part of hepatic sinusoid relationship: BFO:0000050 UBERON:0001281 ! part of hepatic sinusoid property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/2d-ftu/liver-liver-lobule/v1.3/assets/2d-ftu-liver-liver-lobule.png" xsd:string {terms:licence="http://creativecommons.org/licenses/by/4.0/", xref="doi:10.48539/HBM889.CJPK.447"} property_value: RO:0002175 NCBITaxon:9606 property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_1000398" xsd:string {name="endothelial cell of hepatic sinusoid on CELLxGENE CellGuide"} property_value: terms:description "Endothelial cells of hepatic sinusoids, also known as hepatic or liver sinusoidal endothelial cells (HSEC or LSEC), are unique, specialized type of endothelial cells located in the liver. They are the building units of the hepatic sinusoid, which functions as a specialized capillary system that facilitates the exchange of various substances between the blood and hepatocytes. This finely tuned environment, facilitated by HSEC, is primordial for the liver's multiple physiologic functions that include nutrient metabolism, toxin inactivation, and immunomodulation.\nThe HSEC have a distinctive morphology that sets them apart from the typical endothelial cells found in other organs. These cells are exceptionally thin to allow for efficient transfer of molecules and characterized by fenestrations, which are non-diaphragmatic, sieve-like openings that provide an open filtration pathway from the sinusoidal lumen to the space of Disse, where hepatocytes are exposed. The fenestration is a crucial feature that allows lipoproteins, nutrients, and other plasma components easy access to hepatocytes for essential liver functions, including clearance of waste products and metabolic regulation.\nHSECs further play a vital role in immune functionality in the liver. They act as a sentinel, determining the nature of the immune response to encountered particulates. They possess a capacity for antigen presentation and express a series of immune-related surface molecules, which helps in immunosurveillance and immunoregulation. The HSEC also aid in the removal and destruction of virus-infected cells, harmful microorganisms, and circulatory waste products to safeguard liver health and general systemic cleanliness.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1016/j.jhep.2016.07.009", xref="DOI:10.1038/cmi.2016.5", xref="DOI:10.1038/s41575-018-0020-y", xref="DOI:10.1038/s41575-020-00411-3", xref="https://www.sciencedirect.com/topics/immunology-and-microbiology/disse-space"} [Term] id: CL:1000405 name: epithelial cell of appendix def: "An epithelial cell that is part of the appendix." [GOC:tfm] subset: human_subset subset: mouse_subset synonym: "columnar epitheliocyte of appendix" EXACT [FMA:63602] synonym: "epithelial cell of vermiform appendix" EXACT [FMA:63602] xref: FMA:63602 is_a: CL:0002253 ! epithelial cell of large intestine intersection_of: CL:0000066 ! epithelial cell intersection_of: BFO:0000050 UBERON:0009697 ! part of epithelium of appendix relationship: BFO:0000050 UBERON:0009697 ! part of epithelium of appendix [Term] id: CL:1000409 name: myocyte of sinoatrial node def: "A muscle cell that is part of the sinoatrial node." [FMA:67102, GOC:tfm] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "SA nodal myocyte" EXACT [FMA:67102] synonym: "SA node cardiac muscle cell" EXACT [GOC:pr] synonym: "sinoatrial node cell" EXACT [GOC:pr] synonym: "sinoatrial node myocyte" EXACT [] synonym: "sinuatrial node myocyte" EXACT [FMA:67102] xref: FMA:67102 is_a: CL:0002072 ! nodal myocyte is_a: CL:0008009 ! transversely striated visceral muscle cell intersection_of: CL:0000187 ! muscle cell intersection_of: BFO:0000050 UBERON:0002351 ! part of sinoatrial node relationship: BFO:0000050 UBERON:0002351 ! part of sinoatrial node [Term] id: CL:1000410 name: myocyte of atrioventricular node def: "A muscle cell that is part of the atrioventricular node." [FMA:67106, GOC:tfm] subset: human_subset subset: mouse_subset synonym: "atrioventricular node cell" EXACT [GOC:pr] synonym: "atrioventricular node myocyte" EXACT [FMA:67106] synonym: "AV nodal myocyte" EXACT [FMA:67106] synonym: "AV node cardiac muscle cell" EXACT [GOC:pr] synonym: "AV node cell" EXACT [GOC:pr] xref: FMA:67106 is_a: CL:0002072 ! nodal myocyte is_a: CL:0008009 ! transversely striated visceral muscle cell is_a: CL:2000022 ! cardiac septum cell intersection_of: CL:0000187 ! muscle cell intersection_of: BFO:0000050 UBERON:0002352 ! part of atrioventricular node relationship: BFO:0000050 UBERON:0002352 ! part of atrioventricular node [Term] id: CL:1000411 name: endothelial cell of Peyer's patch def: "An endothelial cell that is part of the small intestine Peyer's patch." [GOC:tfm] subset: human_subset subset: mouse_subset xref: FMA:67757 is_a: CL:0000131 ! gut endothelial cell intersection_of: CL:0000115 ! endothelial cell intersection_of: BFO:0000050 UBERON:0003454 ! part of small intestine Peyer's patch relationship: BFO:0000050 UBERON:0003454 ! part of small intestine Peyer's patch [Term] id: CL:1000412 name: endothelial cell of arteriole def: "An endothelial cell that is part of the arteriole." [GOC:tfm] subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset xref: FMA:67760 xref: KUPO:0001097 is_a: CL:0000071 {is_inferred="true"} ! blood vessel endothelial cell intersection_of: CL:0000115 ! endothelial cell intersection_of: BFO:0000050 UBERON:0001980 ! part of arteriole relationship: BFO:0000050 UBERON:0001980 ! part of arteriole property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:1000413 name: endothelial cell of artery alt_id: CL:0002542 def: "A blood vessel endothelial cell that is part of an arterial endothelium." [GOC:tfm] subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "arterial endothelial cell" EXACT [] xref: BTO:0004758 xref: FMA:67761 xref: KUPO:0001095 is_a: CL:0000071 ! blood vessel endothelial cell intersection_of: CL:0000115 ! endothelial cell intersection_of: BFO:0000050 UBERON:0001637 ! part of artery relationship: BFO:0000050 UBERON:0001917 ! part of endothelium of artery property_value: RO:0002175 NCBITaxon:9606 property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_1000413" xsd:string {name="endothelial cell of artery on CELLxGENE CellGuide"} property_value: terms:description "Endothelial cells of the artery, also referred to as arterial endothelial cells, form an integral part of the arterial system. They form a single layer, known as the endothelium, lining the interior surface of arteries, and are able to respond to the high-pressure and flow conditions present in arteries. The primary role of these cells is to provide a barrier between the vessel wall and the blood, exhibiting selective permeability to regulate the movement of liquids, gases, and blood-borne substances across the vascular wall.\nArterial endothelial cells significantly contribute to maintaining vascular homeostasis. They are at the forefront of sensations and responses to mechanical stimuli, like shear stress and blood pressure changes. An additional key function pertains to the production of nitric oxide, which helps to regulate vascular tone and blood pressure, prevents platelet aggregation, limits leukocyte adhesion to the endothelium, and inhibits smooth muscle cell proliferation. These varied but connected functions help to preclude the development of atherosclerosis, ensuring normal circulation and arterial health.\nMoreover, these cells play a pivotal role in inflammation and coagulation processes. During inflammatory events, they express various adhesion molecules, aiding in leukocyte recruitment and rolling onto the vessel walls for immune response. They also produce anticoagulant and procoagulant substances, involved in blood clotting and clot dissolution, respectively. Dysregulation of the usual functions of arterial endothelial cells can result in serious pathophysiological conditions, such as atherosclerosis, hypertension, and other cardiovascular diseases.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1007/s00441-008-0706-5", xref="DOI:10.1007/s10456-021-09785-7", xref="DOI:10.1016/j.ccm.2021.08.005", xref="DOI:10.1016/j.jvs.2004.03.043", xref="DOI:10.1177/153857440303700107"} [Term] id: CL:1000414 name: endothelial cell of venule def: "An endothelial cell that is part of the venule." [GOC:tfm] subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset xref: FMA:67762 is_a: CL:0000071 ! blood vessel endothelial cell intersection_of: CL:0002139 ! endothelial cell of vascular tree intersection_of: BFO:0000050 UBERON:0001979 ! part of venule relationship: BFO:0000050 UBERON:0001979 ! part of venule property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:1000415 name: epithelial cell of gallbladder def: "An epithelial cell that is part of the gallbladder." [GOC:tfm] subset: human_subset subset: mouse_subset xref: FMA:67780 is_a: CL:0000066 ! epithelial cell intersection_of: CL:0000066 ! epithelial cell intersection_of: BFO:0000050 UBERON:0002110 ! part of gallbladder relationship: BFO:0000050 UBERON:0002110 ! part of gallbladder [Term] id: CL:1000416 name: obsolete myoepithelial cell of lactiferous gland def: "OBSOLETE. A myoepithelial cell that is part of the mammary gland." [GOC:tfm] comment: Term merged into CL:0002324 (myoepithelial cell of mammary gland) is_obsolete: true replaced_by: CL:0002324 [Term] id: CL:1000417 name: myoepithelial cell of sweat gland def: "A myoepithelial cell that is part of the sweat gland." [GOC:tfm] subset: human_reference_atlas subset: human_subset subset: mouse_subset xref: FMA:67801 is_a: CL:0000185 {is_inferred="true"} ! myoepithelial cell is_a: CL:1000448 ! epithelial cell of sweat gland intersection_of: CL:0000185 ! myoepithelial cell intersection_of: BFO:0000050 UBERON:0001820 ! part of sweat gland property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/2d-ftu/skin-hair-follicle/v1.0/assets/2d-ftu-skin-hair-follicle.png" xsd:string {terms:licence="http://creativecommons.org/licenses/by/4.0/", xref="doi:10.48539/HBM853.HLFH.534"} property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:1000418 name: myoepithelial cell of lactiferous alveolus def: "A myoepithelial cell that is part of the mammary gland alveolus." [GOC:tfm] subset: human_subset subset: mouse_subset synonym: "basal cell of alveolus of lactiferous gland" EXACT [FMA:67802] synonym: "myoepithelial cell of mammary alveolus" EXACT [FMA:67802] xref: FMA:67802 is_a: CL:0002324 ! basal-myoepithelial cell of mammary gland intersection_of: CL:0000185 ! myoepithelial cell intersection_of: BFO:0000050 UBERON:0003214 ! part of mammary gland alveolus relationship: BFO:0000050 UBERON:0003214 ! part of mammary gland alveolus [Term] id: CL:1000419 name: myoepithelial cell of lactiferous duct def: "A myoepithelial cell that is part of the lactiferous duct." [GOC:tfm] subset: human_subset subset: mouse_subset xref: FMA:67803 is_a: CL:0000068 ! duct epithelial cell is_a: CL:0002324 ! basal-myoepithelial cell of mammary gland intersection_of: CL:0000185 ! myoepithelial cell intersection_of: BFO:0000050 UBERON:0001765 ! part of mammary duct relationship: BFO:0000050 UBERON:0001765 ! part of mammary duct [Term] id: CL:1000420 name: myoepithelial cell of terminal lactiferous duct def: "A myoepithelial cell that is part of the terminal lactiferous duct." [GOC:tfm] subset: human_subset subset: mouse_subset xref: FMA:67804 is_a: CL:0000185 ! myoepithelial cell [Term] id: CL:1000424 name: chromaffin cell of paraaortic body def: "A chromaffin cell that is part of the paraaortic body." [GOC:tfm] subset: human_subset subset: mouse_subset synonym: "chromaffin cell of para-aortic body" EXACT [FMA:69328] xref: FMA:69328 is_a: CL:1000425 ! chromaffin cell of paraganglion intersection_of: CL:0000166 ! chromaffin cell intersection_of: BFO:0000050 UBERON:0001237 ! part of paraaortic body relationship: BFO:0000050 UBERON:0001237 ! part of paraaortic body [Term] id: CL:1000425 name: chromaffin cell of paraganglion def: "A chromaffin cell that is part of the paraganglion." [GOC:tfm] subset: human_subset subset: mouse_subset xref: FMA:69335 is_a: CL:0000166 {is_inferred="true"} ! chromaffin cell intersection_of: CL:0000166 ! chromaffin cell intersection_of: BFO:0000050 UBERON:0012279 ! part of chromaffin paraganglion relationship: BFO:0000050 UBERON:0012279 ! part of chromaffin paraganglion [Term] id: CL:1000426 name: chromaffin cell of adrenal gland def: "A chromaffin cell that is part of the adrenal gland." [GOC:tfm] subset: human_subset subset: mouse_subset synonym: "adrenal chromaffin cell" EXACT [GO:0061104] xref: FMA:69794 is_a: CL:0000150 ! glandular secretory epithelial cell is_a: CL:0000166 {is_inferred="true"} ! chromaffin cell intersection_of: CL:0000166 ! chromaffin cell intersection_of: BFO:0000050 UBERON:0002369 ! part of adrenal gland relationship: BFO:0000050 UBERON:0002369 ! part of adrenal gland [Term] id: CL:1000427 name: adrenal cortex chromaffin cell def: "A chromaffin cell that is part of the adrenal cortex." [GOC:tfm] comment: Not clear this cell type exists. Can't call it a cortical adrenal cell because of different germ layer origin. subset: human_subset subset: mouse_subset synonym: "chromaffin cell of adrenal cortex" EXACT [] xref: FMA:69795 is_a: CL:1000426 ! chromaffin cell of adrenal gland is_a: CL:1001601 ! adrenal gland glandular cell intersection_of: CL:0000166 ! chromaffin cell intersection_of: BFO:0000050 UBERON:0001235 ! part of adrenal cortex [Term] id: CL:1000428 name: stem cell of epidermis def: "A somatic stem cell that is part of the epidermis." [GOC:tfm] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "epidermal stem cell" EXACT [FMA:70541] xref: FMA:70541 xref: ZFA:0007122 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000723 {is_inferred="true"} ! somatic stem cell intersection_of: CL:0000723 ! somatic stem cell intersection_of: BFO:0000050 UBERON:0001003 ! part of skin epidermis relationship: BFO:0000050 UBERON:0001003 ! part of skin epidermis property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_1000428" xsd:string {name="stem cell of epidermis on CELLxGENE CellGuide"} property_value: terms:description "The epidermal stem cell, a critical component of the skin's structure, is essential for maintaining, repairing, and renewing the epidermal layer. Undifferentiated and capable of becoming various cell types within the epidermis, these cells typically remain quiescent, preserving the skin's longevity and regenerative ability.\nThe primary role of these stem cells is to replenish the population of keratinocytes, the key protective cells in the epidermis. When stimulated by signals like injury or normal wear, these stem cells activate, divide, and give rise to both new stem cells and differentiated cells. The latter form layers of stratified keratinocytes that make up the skin's protective barrier.\nBeyond skin-related applications, the regenerative potential of epidermal stem cells has garnered interest in medical and cosmetic fields, particularly for treating burns, chronic wounds, and aging skin. Notably, these cells, specialized for skin tissue, might, under controlled conditions, have the potential to form diverse tissues, expanding possibilities in regenerative medicine.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1146/annurev.cellbio.22.010305.104357", xref="DOI:10.1186/s13287-019-1312-z", xref="DOI:10.3390/ijms161025476", xref="https://www.ncbi.nlm.nih.gov/books/NBK26865/", xref="https://www.sciencedirect.com/topics/medicine-and-dentistry/epidermal-stem-cell"} [Term] id: CL:1000432 name: conjunctival epithelial cell def: "An epithelial cell that is part of the conjunctiva." [GOC:tfm] subset: cellxgene_subset subset: eye_upper_slim subset: human_subset subset: mouse_subset synonym: "epithelial cell of conjunctiva" EXACT [FMA:70552] xref: FMA:70552 is_a: CL:0000066 {is_inferred="true"} ! epithelial cell intersection_of: CL:0000066 ! epithelial cell intersection_of: BFO:0000050 UBERON:0001811 ! part of conjunctiva relationship: BFO:0000050 UBERON:0001811 ! part of conjunctiva property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_1000432" xsd:string {name="conjunctival epithelial cell on CELLxGENE CellGuide"} property_value: terms:description "Conjunctival epithelial cells are located in the outermost layer of the conjunctiva, the transparent mucous membrane that covers the front surface of the eye (sclera) and lines the inside of the eyelids. Depending on the location, the conjunctival epithelium varies from a stratified squamous non-keratinizing epithelium (close to the lid margin) to a stratified columnar epithelium (bulbar). It consists of between two and seven layers of epithelial cells, which are organized into three main types: basal, intermediate and superficial; amongst them are goblet cells, which produce the mucous layer of the tear film, \nThe conjunctival cells play a vital role in preserving the health and functionality of the eye, contributing significantly to ocular defense mechanisms. They also participate in maintaining the ocular surface's physiological environment. Specifically, conjunctival epithelial cells serve as a physical barrier against environmental threats, such as dust, allergens, and microbes. They prevent foreign bodies from entering the eye, thanks to their tightly packed arrangement, which is integral to the eye's first line of defense. \nApart from this physical protection, these conjunctival epithelial cells are also involved in immune defense. They secrete microbicidal and immunomodulatory peptides and cytokines and can recognize and respond to pathogens through their Toll- and NOD-like receptor signaling pathways and modulate DC and lymphocyte function. \nAdditionally, conjunctival goblet cells, assist in maintaining ocular surface moisture by secreting soluble mucins for tear film production, a thin fluid layer that keeps the cornea and conjunctiva moist. This tear film lubricates the eye, protects against infections, and ensures uninterrupted, clear vision.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1016/j.celrep.2021.108715", xref="DOI:10.1016/j.exer.2013.10.008", xref="DOI:10.1111/imm.12716", xref="DOI:10.1167/iovs.17-23623", xref="https://www.sciencedirect.com/topics/neuroscience/conjunctiva-epithelium"} [Term] id: CL:1000433 name: epithelial cell of lacrimal canaliculus def: "An epithelial cell that is part of the lacrimal canaliculus." [GOC:tfm] subset: human_subset subset: mouse_subset xref: FMA:70553 is_a: CL:0000066 ! epithelial cell intersection_of: CL:0000066 ! epithelial cell intersection_of: BFO:0000050 UBERON:0001770 ! part of lacrimal canaliculus relationship: BFO:0000050 UBERON:0001770 ! part of lacrimal canaliculus [Term] id: CL:1000434 name: epithelial cell of external acoustic meatus def: "An epithelial cell that is part of the external acoustic meatus." [GOC:tfm] subset: human_subset subset: mouse_subset xref: FMA:70555 is_a: CL:0000066 ! epithelial cell intersection_of: CL:0000066 ! epithelial cell intersection_of: BFO:0000050 UBERON:0001352 ! part of external acoustic meatus relationship: BFO:0000050 UBERON:0001352 ! part of external acoustic meatus [Term] id: CL:1000435 name: epithelial cell of lacrimal drainage system def: "An epithelial cell that is part of the lacrimal drainage system." [GOC:tfm, PMID:22594785] subset: human_subset subset: mouse_subset synonym: "epithelial cell of lacrimal duct" RELATED [] xref: FMA:70559 is_a: CL:0000072 {is_inferred="true"} ! non-branched duct epithelial cell intersection_of: CL:0000068 ! duct epithelial cell intersection_of: BFO:0000050 UBERON:0001850 ! part of lacrimal drainage system relationship: BFO:0000050 UBERON:0001850 ! part of lacrimal drainage system [Term] id: CL:1000436 name: epithelial cell of lacrimal sac def: "An epithelial cell that is part of the lacrimal sac." [GOC:tfm] subset: human_subset subset: mouse_subset xref: FMA:70560 is_a: CL:1000437 ! epithelial cell of nasolacrimal duct intersection_of: CL:0000066 ! epithelial cell intersection_of: BFO:0000050 UBERON:0001351 ! part of lacrimal sac relationship: BFO:0000050 UBERON:0001351 ! part of lacrimal sac property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_1000436" xsd:string {name="epithelial cell of lacrimal sac on CELLxGENE CellGuide"} property_value: terms:description "Epithelial cells of the lacrimal sac play a significant role in the physiology of tear drainage, acting as an integral part of the lacrimal drainage system. The lacrimal sac is part of the nasolacrimal duct system, a conduit which connects the eye to the nasal cavity, and is lined by multilayered, non-keratinizing, squamous epithelial cells. \nThe epithelial cells of the lacrimal sac are specialized for the purpose of maintaining a moist environment and protecting the surface of the eye. They form a barrier that traps and removes potential contaminants from the tear film during the drainage process. These cells also actively contribute to tear turnover by expediting the drainage of excess tears. Dysfunctional epithelial cells of the lacrimal sac can lead to dacryocystitis, a condition characterized by inflammation of the lacrimal sac.\nEpithelial cells of the lacrimal sac also perform various other tasks which ensure the overall health of the eye. They are involved in the regulation of immune responses within the lacrimal apparatus and may have a possible role in host-microbiome interactions. Thus, epithelial cells of the lacrimal sac play a multifaceted role in tear drainage and ocular surface defence, directly translating to eye health and vision quality.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1007/s004290050160", xref="DOI:10.1111/j.1442-9071.2012.02818.x", xref="DOI:10.1167/tvst.8.4.32", xref="DOI:10.2147/OPTH.S26048", xref="DOI:10.3389/fimmu.2022.918619"} [Term] id: CL:1000437 name: epithelial cell of nasolacrimal duct def: "An epithelial cell that is part of the nasolacrimal duct." [GOC:tfm] subset: human_subset subset: mouse_subset xref: FMA:70561 is_a: CL:1000435 ! epithelial cell of lacrimal drainage system intersection_of: CL:0000072 ! non-branched duct epithelial cell intersection_of: BFO:0000050 UBERON:0002392 ! part of nasolacrimal duct relationship: BFO:0000050 UBERON:0002392 ! part of nasolacrimal duct [Term] id: CL:1000438 name: epithelial cell of wall of inferior part of anal canal def: "An epithelial cell that is part of the wall of inferior part of anal canal." [GOC:tfm] subset: human_subset subset: mouse_subset xref: FMA:70562 is_a: CL:0002634 ! epithelial cell of anal column [Term] id: CL:1000441 name: epithelial cell of viscerocranial mucosa def: "An epithelial cell that is part of the viscerocranial mucosa." [GOC:tfm] subset: human_subset subset: mouse_subset xref: FMA:70583 is_a: CL:0000066 ! epithelial cell [Term] id: CL:1000442 name: urothelial cell of trigone of urinary bladder def: "An urothelial cell that is part of the trigone of urinary bladder." [GOC:tfm] subset: human_subset subset: mouse_subset synonym: "epithelial cell of vesical trigone" EXACT [FMA:70598] xref: FMA:70598 is_a: CL:1001428 ! bladder urothelial cell [Term] id: CL:1000443 name: ciliary muscle cell def: "A smooth muscle cell that is part of the ciliary body." [GOC:tfm] subset: cellxgene_subset subset: eye_upper_slim subset: human_subset subset: mouse_subset synonym: "smooth muscle cell of ciliary body" EXACT [FMA:70610] xref: FMA:70610 is_a: CL:0000192 {is_inferred="true"} ! smooth muscle cell intersection_of: CL:0000192 ! smooth muscle cell intersection_of: BFO:0000050 UBERON:0001775 ! part of ciliary body relationship: BFO:0000050 UBERON:0001775 ! part of ciliary body property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_1000443" xsd:string {name="ciliary muscle cell on CELLxGENE CellGuide"} property_value: terms:description "Ciliary muscle cells are specialized contractile cells that constitute the ciliary muscle, a component of the eye in vertebrates. These cells form a ring around the iris, the eye's colored part. Ciliary muscle cells fall into the category of smooth muscle cells, characterized by their lack of the striations typical of skeletal and cardiac muscle cells. Their shape is elongated and pointed at both ends, and they occur in multi-nucleated syncytia where many cells share the same cytoplasm.\nCiliary muscle cells primarily control the eye's accommodation, adjusting the thickness and curvature of the lens to fine-tune the focus of light on the retina. When ciliary muscle cells contract, tension on the zonular fibers holding the lens in place is reduced, allowing the lens to become thicker and increase its refractive power. Conversely, when the ciliary muscle cells relax, the tension on the zonular fibers increases, causing the lens to become flatter and decrease its refractive power. This adjustment facilitates clear vision at different distances, ranging from near to far objects.\nAdditionally, ciliary muscle cells play a role in draining the eye's aqueous humor, which is the clear fluid that fills the anterior chamber of the eye between the cornea and the lens. By controlling the shape of the surrounding trabecular meshwork through muscle contractions and relaxations, ciliary muscle cells indirectly regulate intraocular pressure, a factor critical for preventing ocular conditions like glaucoma.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1016/S1350-9462(98)00011-1", xref="DOI:10.1038/srep31171", xref="DOI:10.1111/j.1444-0938.2008.00260.x", xref="https://www.sciencedirect.com/topics/medicine-and-dentistry/ciliary-muscle"} [Term] id: CL:1000444 name: mesothelial cell of anterior chamber of eye def: "A mesothelial cell that is part of the anterior chamber of eyeball." [GOC:tfm] subset: human_subset subset: mouse_subset xref: FMA:70615 is_a: CL:0000077 ! mesothelial cell intersection_of: CL:0000077 ! mesothelial cell intersection_of: BFO:0000050 UBERON:0001766 ! part of anterior chamber of eyeball relationship: BFO:0000050 UBERON:0001766 ! part of anterior chamber of eyeball [Term] id: CL:1000445 name: myoepithelial cell of dilator pupillae def: "A myoepithelial cell that is part of the dilatator pupillae." [GOC:tfm] subset: human_subset subset: mouse_subset xref: FMA:70619 is_a: CL:0000185 {is_inferred="true"} ! myoepithelial cell intersection_of: CL:0000185 ! myoepithelial cell intersection_of: BFO:0000050 UBERON:0001608 ! part of dilatator pupillae relationship: BFO:0000050 UBERON:0001608 ! part of dilatator pupillae [Term] id: CL:1000447 name: epithelial cell of stratum germinativum of esophagus def: "A basal cell that is part of the epithelium of esophagus." [GOC:tfm] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "basal cell of esophageal epithelium" EXACT [FMA:70731] xref: FMA:70731 is_a: CL:0000646 {is_inferred="true"} ! basal cell intersection_of: CL:0000646 ! basal cell intersection_of: BFO:0000050 UBERON:0001976 ! part of epithelium of esophagus relationship: BFO:0000050 UBERON:0001976 ! part of epithelium of esophagus property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_1000447" xsd:string {name="epithelial cell of stratum germinativum of esophagus on CELLxGENE CellGuide"} property_value: terms:description "The epithelial cell in the stratum germinativum of the esophagus, commonly referred to as a basal cell, is a crucial component of the body's mechanism for tissue homeostasis and regeneration. Situated in the deepest layer of the esophageal lining, these cells are pivotal in preserving the integrity of the esophagus, which faces exposure to various physical and chemical irritants like stomach acid, food particles, and pathogens.\nThese cells are renowned for their proliferative potential. When the superficial layers of the esophageal epithelium are damaged, these basal cells are triggered to multiply, differentiate, and migrate upwards to restore the integrity and function of the affected tissue. This process, known as regeneration or repair, ensures that the esophageal wall remains continuous and functional, capable of performing its primary task: the conveyance of food and drink from the mouth to the stomach.\nHowever, it's crucial to recognize that the continuous cycle of damage and repair in the esophageal epithelium, driven by the epithelial cells of the stratum germinativum, can result in pathological conditions like Barrett's esophagus and esophageal cancer. Under certain conditions, these basal cells may deviate from their normal differentiation into squamous cells and instead transform into abnormal cell types, such as intestinal columnar cells, contributing to the development of these diseases.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1016/j.tcb.2018.04.007", xref="DOI:10.1038/nrc2773", xref="DOI:10.1136/gut.2005.089144"} [Term] id: CL:1000448 name: epithelial cell of sweat gland def: "An epithelial cell that is part of the sweat gland." [GOC:tfm] subset: cellxgene_subset subset: human_subset subset: mouse_subset xref: FMA:70952 is_a: CL:0000362 ! epidermal cell is_a: CL:0002308 ! epithelial cell of skin gland intersection_of: CL:0000066 ! epithelial cell intersection_of: BFO:0000050 UBERON:0001820 ! part of sweat gland relationship: BFO:0000050 UBERON:0001820 ! part of sweat gland property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_1000448" xsd:string {name="epithelial cell of sweat gland on CELLxGENE CellGuide"} property_value: terms:description "Epithelial cells of sweat glands, also known as sudoriferous glandular cells, play a crucial role in the body's thermoregulation, waste excretion, and hydration balance. They form the main structure of the sweat glands, which are effectively long, coiled tubes located in the dermis. There are two types of sweat glands – eccrine glands, which typically open directly onto the skin surface (e.g. on palms and soles), and apocrine glands, which open onto associated hair follicles (e.g. in arm pits). \nEccrine glands consist of a tube-shaped duct that ends in a coiled, secretory unit made up of three types of epithelial cells – dark, clear and myoepithelial. The dark cells contain basophilic granules to secrete sialomucin, while clear cells secrete glycogen-containing aqueous material; the myoepithelial cells contract in response to stimuli to assist with secretion. Apocrine glands have a similar structure, but their secretory component is larger. \nThe primary function of the epithelial cells of these glands is to produce sweat, a bodily fluid made mostly of water, but also containing trace amounts of salts, glucose, urea, and other substances. This process begins with the secretion of a primary sweat fluid - an isotonic solution derived from the blood plasma - into the glandular lumen. Subsequently, as this primary sweat passes through the gland's duct, reabsorption of sodium ions occurs, leading to a hypotonic final sweat that is excreted onto the skin's surface. This sweat evaporates, removing heat from the body and thus, cooling it down. \nIn addition, epithelial cells of sweat glands contribute to the body's immune defense system. As part of the innate skin barrier function, they secrete antimicrobial peptides and proteins, such as dermcidin, which can inhibit the growth of harmful microorganisms on the skin surface. They also aid in maintaining skin pH and contribute to fluid balance by regulating water resorption. Consequently, any dysfunction in these cells can lead to conditions like hyperhidrosis, anhidrosis, and certain skin infections. Thus, these epithelial cells of sweat glands play a multifaceted role in health and disease.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1080/23328940.2019.1632145", xref="DOI:10.1111/exd.12773", xref="https://doi.org/10.1038/s41419-019-1485-5", xref="https://www.ncbi.nlm.nih.gov/books/NBK482278/", xref="https://www.ncbi.nlm.nih.gov/books/NBK513244/"} [Term] id: CL:1000449 name: epithelial cell of nephron def: "An epithelial cell that is part of the nephron." [GOC:tfm] subset: cellxgene_subset subset: human_subset subset: mouse_subset xref: FMA:70965 is_a: CL:0002518 ! kidney epithelial cell intersection_of: CL:0000066 ! epithelial cell intersection_of: BFO:0000050 UBERON:0001285 ! part of nephron relationship: BFO:0000050 UBERON:0001285 ! part of nephron property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_1000449" xsd:string {name="epithelial cell of nephron on CELLxGENE CellGuide"} property_value: terms:description "Epithelial cells of the nephron form the epithelial lining of the nephron, the functional unit of the kidney that filters the blood to produce urine. Each kidney holds approximately one million nephrons, each of which is composed of several distinct parts, including the renal corpuscle, the proximal tubule, the loop of Henle, and the distal tubule. All sections are lined with highly specialized epithelial cells adapted to perform different functions within the sections of the nephron. \nThe different epithelial cells of the nephron play crucial roles in the process of filtration, reabsorption, secretion, and excretion, essential tasks for the regulation of body fluid composition and volume. During filtration, the blood is forced through the walls of glomerular capillaries into the Bowman's capsule, where waste products, electrolytes, and water are separated from the blood cells and proteins. As the filtrate then passes through the nephron, epithelial cells of the tubular portion reabsorb useful substances such as glucose, amino acids, and electrolytes, along with most of the water back into the bloodstream. Waste products like urea and creatinine, as well as excess ions and water, remain in the tubule for elimination.\nIn addition, epithelial cells of the nephron also play a vital part in maintaining the body's acid-base balance by actively secreting hydrogen ions into the urine while reabsorbing bicarbonate from the urine back into the blood. They are also involved in the regulation of blood pressure through the renin-angiotensin-aldosterone system and contribute to erythrocyte production by releasing the hormone erythropoietin in response to low oxygen levels in the blood. Abnormalities or damage in renal epithelial cells often result in impaired kidney function, leading to various renal diseases.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1007/978-94-011-2354-9_6", xref="DOI:10.1007/s004670050586", xref="DOI:10.1016/B978-0-323-35775-3.00011-4", xref="DOI:10.1146/annurev-physiol-052521-121841", xref="DOI:10.1681/ASN.2012010029"} [Term] id: CL:1000450 name: epithelial cell of glomerular capsule def: "An epithelial cell that is part of the glomerular capsule." [GOC:tfm] subset: cellxgene_subset subset: human_subset subset: kidney_upper_slim subset: mouse_subset synonym: "Bowmans capsule epithelial cell" EXACT [] synonym: "epithelial cell of Bowman's capsule" EXACT [FMA:70966] xref: FMA:70966 xref: KUPO:0001034 is_a: CL:1000510 ! kidney glomerular epithelial cell intersection_of: CL:0000066 ! epithelial cell intersection_of: BFO:0000050 UBERON:0001230 ! part of glomerular capsule relationship: BFO:0000050 UBERON:0001230 ! part of glomerular capsule [Term] id: CL:1000451 name: obsolete epithelial cell of visceral layer of glomerular capsule is_obsolete: true replaced_by: CL:0000653 [Term] id: CL:1000452 name: parietal epithelial cell alt_id: CL:1000897 def: "An epithelial cell that is part of the glomerular parietal epithelium." [GOC:tfm] subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "epithelial cell of parietal layer of glomerular capsule" EXACT [FMA:70968] xref: FMA:70968 xref: KUPO:0001035 is_a: CL:1000450 ! epithelial cell of glomerular capsule intersection_of: CL:0000066 ! epithelial cell intersection_of: BFO:0000050 UBERON:0005750 ! part of glomerular parietal epithelium relationship: BFO:0000050 UBERON:0005750 ! part of glomerular parietal epithelium property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/2d-ftu/kidney-renal-corpuscle/v1.2/assets/2d-ftu-kidney-renal-corpuscle.png" xsd:string {terms:licence="http://creativecommons.org/licenses/by/4.0/", xref="doi:10.48539/HBM778.SHGJ.294"} property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:1000453 name: epithelial cell of intermediate tubule def: "An epithelial cell that is part of the intermediate tubule." [GOC:tfm] subset: human_subset subset: mouse_subset xref: FMA:70980 is_a: CL:1000909 ! kidney loop of Henle epithelial cell intersection_of: CL:1000494 ! nephron tubule epithelial cell intersection_of: BFO:0000050 UBERON:0004136 ! part of intermediate tubule relationship: BFO:0000050 UBERON:0004136 ! part of intermediate tubule [Term] id: CL:1000454 name: kidney collecting duct epithelial cell def: "An epithelial cell that is part of the collecting duct of renal tubule." [GOC:tfm] subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: kidney_upper_slim subset: mouse_subset synonym: "epithelial cell of renal collecting tubule" EXACT [FMA:70982] xref: FMA:70982 xref: KUPO:0001059 is_a: CL:0000072 {is_inferred="true"} ! non-branched duct epithelial cell is_a: CL:1000449 ! epithelial cell of nephron is_a: CL:1001225 {is_inferred="true"} ! kidney collecting duct cell intersection_of: CL:0000066 ! epithelial cell intersection_of: BFO:0000050 UBERON:0001232 ! part of collecting duct of renal tubule property_value: RO:0002175 NCBITaxon:9606 property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_1000454" xsd:string {name="kidney collecting duct epithelial cell on CELLxGENE CellGuide"} property_value: terms:description "Kidney collecting duct epithelial cells are a specialized type of cells that form an integral part of the renal system. Located in the collecting duct system of the kidneys, these cells are responsible for one of the final steps in the process of urine formation, and they are instrumental in the fine tuning of the volume and composition of urine by reabsorbing water and certain solutes back into the bloodstream.\nThese cells express specific channels and carriers that actively and passively transport ions and water. They also have channels on their membranes, such as sodium channels and potassium channels, involved in reabsorbing or secreting these electrolytes depending upon the body's needs. The function of renal collecting duct epithelial cells can be regulated by a variety of hormones, including vasopressin (antidiuretic hormone), which can modulate the ion channels and carriers and hence indirectly influence body fluid homeostasis.\nAside from their function in ion and water balance, kidney collecting duct epithelial cells also aid in maintaining the body's acid-base balance. They have specialized functionality to secret hydrogen ions into the tubular lumen, which contributes to acid excretion. Any dysfunction may have serious implications and lead to various renal or systemic diseases, exemplifying the importance of these cells in maintaining overall body homeostasis.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1016/j.ajpath.2014.01.014", xref="DOI:10.1016/j.semnephrol.2019.04.005", xref="DOI:10.2215/CJN.05760513", xref="DOI:10.2215/CJN.08880914"} [Term] id: CL:1000456 name: mesothelial cell of parietal peritoneum def: "A mesothelial cell that is part of the parietal peritoneum." [GOC:tfm] subset: human_subset subset: mouse_subset xref: FMA:72142 is_a: CL:1000490 ! mesothelial cell of peritoneum intersection_of: CL:0000077 ! mesothelial cell intersection_of: BFO:0000050 UBERON:0001366 ! part of parietal peritoneum relationship: BFO:0000050 UBERON:0001366 ! part of parietal peritoneum [Term] id: CL:1000457 name: mesothelial cell of visceral peritoneum def: "A mesothelial cell that is part of the visceral peritoneum." [GOC:tfm] subset: human_reference_atlas subset: human_subset subset: mouse_subset xref: FMA:72143 is_a: CL:1000490 ! mesothelial cell of peritoneum intersection_of: CL:0000077 ! mesothelial cell intersection_of: BFO:0000050 UBERON:0001178 ! part of visceral peritoneum relationship: BFO:0000050 UBERON:0001178 ! part of visceral peritoneum property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:1000458 name: melanocyte of skin def: "A melanocyte that is part of the skin of body." [GOC:tfm] subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "skin melanocyte" EXACT [FMA:72144] xref: CALOHA:TS-2374 xref: FMA:72144 is_a: CL:0000148 {is_inferred="true"} ! melanocyte intersection_of: CL:0000148 ! melanocyte intersection_of: BFO:0000050 UBERON:0002097 ! part of skin of body relationship: BFO:0000050 UBERON:0002097 ! part of skin of body property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/2d-ftu/skin-epidermal-ridge/v1.2/assets/2d-ftu-skin-epidermal-ridge.png" xsd:string {terms:licence="http://creativecommons.org/licenses/by/4.0/", xref="doi:10.48539/HBM642.BMZS.772"} property_value: RO:0002175 NCBITaxon:9606 property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_1000458" xsd:string {name="melanocyte of skin on CELLxGENE CellGuide"} property_value: terms:description "Melanocytes of the skin are specialized pigment cells crucial for producing and distributing melanin, the pigment determining skin, in addition to hair and eye color. Located in the basal layer of the epidermis, melanocytes serve as a natural sunscreen, protecting skin cells from harmful UV radiation. Structurally dendritic, they synthesize melanin through melanogenesis, transferring melanosomes to keratinocytes for UV shielding\nBeyond pigmentation and UV protection, melanocytes play roles in immune and inflammatory responses. They respond to environmental changes, communicate with skin cell types, and secrete cytokines and growth factors influencing skin homeostasis. Dysregulation may lead to pigment disorders like vitiligo and melasma or contribute to skin cancer, particularly malignant melanoma.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1016/j.jinf.2015.06.006", xref="DOI:10.1111/j.1751-1097.2007.00226.x", xref="DOI:10.1615/CritRevEukaryotGeneExpr.2020028454", xref="DOI:10.5114/pdia.2013.33376", xref="https://www.sciencedirect.com/topics/biochemistry-genetics-and-molecular-biology/melanocyte"} [Term] id: CL:1000465 name: chromaffin cell of ovary def: "A chromaffin cell that is part of the ovary." [GOC:tfm] subset: human_subset subset: mouse_subset xref: FMA:74319 is_a: CL:0000166 {is_inferred="true"} ! chromaffin cell intersection_of: CL:0000166 ! chromaffin cell intersection_of: BFO:0000050 UBERON:0000992 ! part of ovary relationship: BFO:0000050 UBERON:0000992 ! part of ovary [Term] id: CL:1000466 name: chromaffin cell of right ovary def: "A chromaffin cell that is part of the right ovary." [GOC:tfm] subset: human_subset subset: mouse_subset xref: FMA:74320 is_a: CL:1000465 ! chromaffin cell of ovary intersection_of: CL:0000166 ! chromaffin cell intersection_of: BFO:0000050 UBERON:0002118 ! part of right ovary relationship: BFO:0000050 UBERON:0002118 ! part of right ovary [Term] id: CL:1000467 name: chromaffin cell of left ovary def: "A chromaffin cell that is part of the left ovary." [GOC:tfm] subset: human_subset subset: mouse_subset xref: FMA:74321 is_a: CL:1000465 ! chromaffin cell of ovary intersection_of: CL:0000166 ! chromaffin cell intersection_of: BFO:0000050 UBERON:0002119 ! part of left ovary relationship: BFO:0000050 UBERON:0002119 ! part of left ovary [Term] id: CL:1000468 name: myoepithelial cell of acinus of lactiferous gland def: "A myoepithelial cell that is part of the acinus of lactiferous gland." [GOC:tfm] subset: human_subset subset: mouse_subset synonym: "basal cell of acinus of lactiferous gland" EXACT [FMA:74469] xref: FMA:74469 is_a: CL:0002324 ! basal-myoepithelial cell of mammary gland relationship: BFO:0000050 UBERON:0001912 ! part of lobule of mammary gland [Term] id: CL:1000469 name: myoepithelial cell of main lactiferous duct def: "A myoepithelial cell that is part of the main lactiferous duct." [GOC:tfm] subset: human_subset subset: mouse_subset xref: FMA:74499 is_a: CL:0000185 ! myoepithelial cell [Term] id: CL:1000470 name: myoepithelial cell of primary lactiferous duct def: "A myoepithelial cell that is part of the primary lactiferous duct." [GOC:tfm] subset: human_subset subset: mouse_subset xref: FMA:74500 is_a: CL:0000185 ! myoepithelial cell [Term] id: CL:1000471 name: myoepithelial cell of secondary lactiferous duct def: "A myoepithelial cell that is part of the secondary lactiferous duct." [GOC:tfm] subset: human_subset subset: mouse_subset xref: FMA:74501 is_a: CL:0000185 ! myoepithelial cell [Term] id: CL:1000472 name: myoepithelial cell of tertiary lactiferous duct def: "A myoepithelial cell that is part of the tertiary lactiferous duct." [GOC:tfm] subset: human_subset subset: mouse_subset xref: FMA:74502 is_a: CL:0000185 ! myoepithelial cell [Term] id: CL:1000473 name: myoepithelial cell of quarternary lactiferous duct def: "A myoepithelial cell that is part of the quarternary lactiferous duct." [GOC:tfm] subset: human_subset subset: mouse_subset xref: FMA:74503 is_a: CL:0000185 ! myoepithelial cell [Term] id: CL:1000477 name: cardiac pacemaker cell of sinoatrial node def: "A nodal myocyte that is part of the sinoatrial node." [GOC:tfm] subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "cardiac pacemaker cell of sinuatrial node" EXACT [] synonym: "pacemaker cell of sinoatrial node" EXACT [] synonym: "pacemaker cell of sinuatrial node" EXACT [] xref: FMA:83383 is_a: CL:1000409 ! myocyte of sinoatrial node property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:1000478 name: transitional myocyte of sinoatrial node def: "A transitional myocyte that is part of the sinoatrial node." [GOC:tfm] subset: human_subset subset: mouse_subset synonym: "transitinal myocyte of sinuatrial node" EXACT [] xref: FMA:83384 is_a: CL:0002073 {is_inferred="true"} ! transitional myocyte is_a: CL:1000409 ! myocyte of sinoatrial node intersection_of: CL:0002073 ! transitional myocyte intersection_of: BFO:0000050 UBERON:0002351 ! part of sinoatrial node [Term] id: CL:1000479 name: Purkinje myocyte of atrioventricular node def: "A Purkinje myocyte that is part of the atrioventricular node." [GOC:tfm] subset: human_subset subset: mouse_subset xref: FMA:83386 is_a: CL:0002068 {is_inferred="true"} ! Purkinje myocyte is_a: CL:1000410 ! myocyte of atrioventricular node intersection_of: CL:0002068 ! Purkinje myocyte intersection_of: BFO:0000050 UBERON:0002352 ! part of atrioventricular node [Term] id: CL:1000480 name: transitional myocyte of internodal tract def: "A transitional myocyte that is part of the internodal tract." [GOC:tfm] subset: human_subset subset: mouse_subset xref: FMA:83387 is_a: CL:0002073 {is_inferred="true"} ! transitional myocyte is_a: CL:0002096 ! internodal tract myocyte intersection_of: CL:0002073 ! transitional myocyte intersection_of: BFO:0000050 UBERON:0009966 ! part of internodal tract [Term] id: CL:1000481 name: transitional myocyte of atrioventricular bundle def: "A transitional myocyte that is part of the atrioventricular bundle." [GOC:tfm] subset: human_subset subset: mouse_subset xref: FMA:83388 is_a: CL:0002073 {is_inferred="true"} ! transitional myocyte is_a: CL:0008009 ! transversely striated visceral muscle cell is_a: CL:0010005 ! atrioventricular bundle cell is_a: CL:2000046 ! ventricular cardiac muscle cell intersection_of: CL:0002073 ! transitional myocyte intersection_of: BFO:0000050 UBERON:0002353 ! part of bundle of His [Term] id: CL:1000482 name: myocardial endocrine cell of interventricular septum def: "A myocardial endocrine cell that is part of the interventricular septum." [GOC:tfm] subset: human_subset subset: mouse_subset xref: FMA:83390 is_a: CL:0002074 {is_inferred="true"} ! myocardial endocrine cell is_a: CL:2000022 ! cardiac septum cell intersection_of: CL:0002074 ! myocardial endocrine cell intersection_of: BFO:0000050 UBERON:0002094 ! part of interventricular septum relationship: BFO:0000050 UBERON:0002094 ! part of interventricular septum [Term] id: CL:1000483 name: Purkinje myocyte of internodal tract def: "A Purkinje myocyte that is part of the internodal tract." [GOC:tfm] subset: human_subset subset: mouse_subset xref: FMA:83392 is_a: CL:0002068 {is_inferred="true"} ! Purkinje myocyte is_a: CL:0002096 ! internodal tract myocyte intersection_of: CL:0002068 ! Purkinje myocyte intersection_of: BFO:0000050 UBERON:0009966 ! part of internodal tract [Term] id: CL:1000484 name: Purkinje myocyte of atrioventricular bundle def: "A Purkinje myocyte that is part of the atrioventricular bundle." [GOC:tfm] subset: human_subset subset: mouse_subset xref: FMA:83393 is_a: CL:0002068 {is_inferred="true"} ! Purkinje myocyte is_a: CL:0008009 ! transversely striated visceral muscle cell is_a: CL:0010005 ! atrioventricular bundle cell is_a: CL:2000046 ! ventricular cardiac muscle cell intersection_of: CL:0002068 ! Purkinje myocyte intersection_of: BFO:0000050 UBERON:0002353 ! part of bundle of His [Term] id: CL:1000486 name: basal cell of urothelium def: "A basal cell that is part of the urothelium. Compared to other urothelial cell types, a basal cell of the urothelium is positioned along the basement membrane, is the most undifferentiated and serves a progenitor role." [doi:10.1038/s41385-022-00565-0, GOC:tfm] comment: It has been noted in at least some mammalian species that the urothelial basal cell type is distinguished by expression of high levels of cytokeratin-5 (CK5), p63 and the signalling molecule Sonic hedgehog (Shh). Similar to intermediate cells, the urothelial basal cell type expresses CK17 but is negative for uroplakins (UPK) and CK20. Urothelial basal cells have also been noted to be smaller in diameter than urothelial intermediate cells. {xref="doi:10.1038/s41385-022-00565-0"} subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "urothelial basal cell" EXACT [doi:10.1007/978-3-030-14366-4_8, doi:10.1111/cpr.13170] xref: FMA:84150 is_a: CL:0000646 {is_inferred="true"} ! basal cell is_a: CL:0000731 ! urothelial cell intersection_of: CL:0000646 ! basal cell intersection_of: BFO:0000050 UBERON:0000365 ! part of urothelium property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:1000487 name: smooth muscle cell of prostate def: "A smooth muscle cell that is part of the prostate gland." [GOC:tfm] subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "smooth muscle fiber of prostate" EXACT [FMA:84583] xref: FMA:84583 is_a: CL:0000192 {is_inferred="true"} ! smooth muscle cell intersection_of: CL:0000192 ! smooth muscle cell intersection_of: BFO:0000050 UBERON:0002367 ! part of prostate gland relationship: BFO:0000050 UBERON:0002367 ! part of prostate gland property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/2d-ftu/prostate-prostate-glandular-acinus/v1.2/assets/2d-ftu-prostate-prostate-glandular-acinus.png" xsd:string {terms:licence="http://creativecommons.org/licenses/by/4.0/", xref="doi:10.48539/HBM347.TXWZ.899"} property_value: RO:0002175 NCBITaxon:9606 property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_1000487" xsd:string {name="smooth muscle cell of prostate on CELLxGENE CellGuide"} property_value: terms:description "Smooth muscle cells of the prostate constitute a critical component of the prostatic stroma, enveloping glandular structures to support functions like secretion and fluid expulsion. Like other smooth muscles, smooth muscle cells of the prostate lack the striations characteristic of skeletal and cardiac muscle cell.\nFunctionally, they play a crucial role in reproductive and urinary functions. Smooth muscle cells of the prostate contribute to the transport and expulsion of prostatic secretions into the urethra and respond dynamically to signaling molecules such as hormones and neurotransmitters. For instance, under sympathetic nervous stimulation, they contract and apply pressure on the gland's ducts, facilitating the secretion process.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1101/cshperspect.a030510", xref="https://www.ncbi.nlm.nih.gov/books/NBK279291", xref="https://www.sciencedirect.com/topics/immunology-and-microbiology/smooth-muscle-cell"} [Term] id: CL:1000488 name: cholangiocyte def: "An epithelial cell that is part of the bile duct. Cholangiocytes contribute to bile secretion via net release of bicarbonate and water. They are cuboidal epithelium in the small interlobular bile ducts, but become columnar and mucus secreting in larger bile ducts approaching the porta hepatis and the extrahepatic ducts." [GOC:tfm, PMID:16550043, PMID:18356246] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "epithelial cell of bile duct" EXACT [] xref: FMA:86481 xref: ZFA:0009397 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: BFO:0000002 is_a: CL:0000069 {is_inferred="true"} ! branched duct epithelial cell intersection_of: CL:0000069 ! branched duct epithelial cell intersection_of: BFO:0000050 UBERON:0002394 ! part of bile duct intersection_of: RO:0002215 GO:0015106 ! capable of bicarbonate transmembrane transporter activity relationship: BFO:0000050 UBERON:0002394 ! part of bile duct relationship: RO:0002202 CL:0005026 ! develops from hepatoblast property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_1000488" xsd:string {name="cholangiocyte on CELLxGENE CellGuide"} property_value: terms:description "Cholangiocytes, also known as biliary epithelial cells, are specialized epithelial cells that line the biliary tract, which constitutes the gall bladder and bile ducts inside the liver. Crucial to the maintenance of the liver's health and function, cholangiocytes have a key role in the modification and secretion of bile, a fluid produced by hepatocytes that is essential to digestion and the absorption of fats and vitamins.\nCholangiocytes accomplish their primary function through the expression of a variety of transport proteins located on their apical and basolateral membranes, which propel bile acids and other contents of the bile into the biliary lumen. The hepatic bile, once secreted by the hepatocytes, is further modified by cholangiocytes via secretion and absorption processes. These processes help in the regulation of bile volume and composition, which is fundamental in ensuring the efficient digestion of dietary fats and fat-soluble vitamins and the excretion of cholesterol.\nIn addition to their role in bile modification, cholangiocytes also perform several other integral functions. For instance, these cells express Toll-like receptors (TLRs) which allow cholangiocytes to initiate an immune response against pathogens in the biliary lumen. When functioning normally, these cells contribute to biliary integrity, hepatic architecture, and overall hepatic physiology. However, when they become pathological, they are involved in the progression of liver diseases, such as primary biliary cirrhosis and cholangiocarcinoma – the malignancy of the biliary tract.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1016/j.jcmgh.2015.05.005", xref="DOI:10.1016/j.jhep.2012.10.011", xref="DOI:10.1038/s41575-019-0125-y", xref="DOI:10.1152/ajpgi.00227.2012", xref="DOI:10.5009/gnl16033"} [Term] id: CL:1000489 name: reticular cell of splenic cord def: "A reticular cell that is part of the splenic cord." [GOC:tfm] subset: human_reference_atlas subset: human_subset subset: mouse_subset xref: FMA:86497 is_a: CL:0000432 {is_inferred="true"} ! reticular cell is_a: CL:2000051 ! splenic fibroblast intersection_of: CL:0000432 ! reticular cell intersection_of: BFO:0000050 UBERON:0001266 ! part of splenic cord relationship: BFO:0000050 UBERON:0001266 ! part of splenic cord property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/2d-ftu/spleen-white-pulp/v1.2/assets/2d-ftu-spleen-white-pulp.png" xsd:string {terms:licence="http://creativecommons.org/licenses/by/4.0/", xref="doi:10.48539/HBM559.FNBB.6273"} property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:1000490 name: mesothelial cell of peritoneum def: "A mesothelial cell that is part of the peritoneum." [GOC:tfm] subset: human_subset subset: mouse_subset synonym: "peritoneal mesothelial cell" EXACT [FMA:86736] xref: FMA:86736 is_a: CL:0000077 ! mesothelial cell intersection_of: CL:0000077 ! mesothelial cell intersection_of: BFO:0000050 UBERON:0002358 ! part of peritoneum relationship: BFO:0000050 UBERON:0002358 ! part of peritoneum [Term] id: CL:1000491 name: mesothelial cell of pleura def: "A mesothelial cell that is part of the pleura." [GOC:tfm] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "pleural mesothelial cell" EXACT [FMA:86737] xref: FMA:86737 is_a: CL:0000077 ! mesothelial cell intersection_of: CL:0000077 ! mesothelial cell intersection_of: BFO:0000050 UBERON:0000977 ! part of pleura relationship: BFO:0000050 UBERON:0000977 ! part of pleura property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_1000491" xsd:string {name="mesothelial cell of pleura on CELLxGENE CellGuide"} property_value: terms:description "Mesothelial cells of the pleura form a significant part of the pleural membrane, a thin, double-layered serous membrane that lines the thoracic cavity and encompasses the lungs. These specialized cells contribute to the pleura's key function of producing a lubricating serous fluid, which reduces friction between the lung's outer surface (visceral pleura) and the inner lining of the thoracic cavity (parietal pleura) during respiration. \nThe cellular structure of mesothelial cells, characterized by microvilli on their surface, aids in the secretion and absorption of the pleural fluid, effectively supporting the smooth expansion and contraction of the lungs. Dysregulation in mesothelial cells can lead to pathologies, including pleural effusion and malignant mesothelioma.\nMesothelial cells of the pleura display unique immunologic properties. They act as a first line of defense against infection because they are able to recognize pathogens and respond by secreting various cytokines and chemokines. Additionally, these cells are directly involved in the translocation of immune cells into the pleural cavity during inflammatory response, thereby playing an active role in the immune response within the pleural environment. \nIn the event of pleural injury, these cells are also involved in the mesothelial-mesenchymal transition, a process that allows mesothelial cells to transdifferentiate into myofibroblasts and promote tissue repair.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1016/j.ccm.2021.08.005", xref="DOI:10.1016/j.coi.2020.04.005", xref="DOI:10.1152/ajplung.90587.2008", xref="DOI:10.3389/fphys.2014.00284"} [Term] id: CL:1000492 name: mesothelial cell of parietal pleura def: "A mesothelial cell that is part of the parietal pleura." [GOC:tfm] subset: human_subset subset: mouse_subset xref: FMA:86738 is_a: CL:1000491 ! mesothelial cell of pleura intersection_of: CL:0000077 ! mesothelial cell intersection_of: BFO:0000050 UBERON:0002400 ! part of parietal pleura relationship: BFO:0000050 UBERON:0002400 ! part of parietal pleura [Term] id: CL:1000493 name: mesothelial cell of visceral pleura def: "A mesothelial cell that is part of the visceral pleura." [GOC:tfm] subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset xref: FMA:86739 is_a: CL:1000491 ! mesothelial cell of pleura intersection_of: CL:0000077 ! mesothelial cell intersection_of: BFO:0000050 UBERON:0002401 ! part of visceral pleura relationship: BFO:0000050 UBERON:0002401 ! part of visceral pleura property_value: RO:0002175 NCBITaxon:9606 property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_1000493" xsd:string {name="mesothelial cell of visceral pleura on CELLxGENE CellGuide"} property_value: terms:description "Mesothelial cells of visceral pleura are specialized epithelial cells that line the inner layer of the pleura, the membrane that envelops the lungs. Positioned adjacent to the lung tissue, these cells form a protective barrier and contribute to the structure of the visceral pleura. They are characterized by their cuboidal to squamous epithelial shape and the presence of microvilli on their surface, a feature aiding in fluid and solute exchange between the pleura and the lungs.\nThe primary function of mesothelial cells of visceral pleura is to secrete a lubricating serous fluid to facilitate smooth, frictionless lung movement within the thoracic cavity during respiration. This helps in the prevention of trauma or damage stemming from the constant rubbing of the lung tissue against the chest wall, hence playing a pivotal role in maintaining respiratory function. Besides fluid secretion, these cells have an essential role in the transportation of fluids and particles across the pleura, as well as in inflammation, wound healing, and tissue repair processes within the pleura.\nMesothelial cells of visceral pleura are notably implicated in the development of pleural diseases such as pleural effusion and pleural mesothelioma, a rare and aggressive form of cancer primarily linked with exposure to asbestos. Alterations, such as hyperplasia or metaplasia, may occur in these mesothelial cells under pathological conditions.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1016/S1357-2725(03)00242-5", xref="DOI:10.1152/physrev.00026.2003", xref="DOI:10.1371/journal.pone.0276978", xref="DOI:10.3389/fphys.2014.00221", xref="DOI:10.3390/jdb7020007"} [Term] id: CL:1000494 name: nephron tubule epithelial cell def: "An epithelial cell that is part of a nephron tubule." [GOC:tfm] comment: This needs to be further defined as a juxtamedullary nephron. Will request the juxtamedullary nephron tubule class from UBERON. subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "kidney tubule epithelial cell" EXACT [] xref: FMA:86785 xref: KUPO:0001022 is_a: CL:1000449 ! epithelial cell of nephron is_a: CL:1000507 ! kidney tubule cell intersection_of: CL:0000066 ! epithelial cell intersection_of: BFO:0000050 UBERON:0004810 ! part of nephron tubule epithelium relationship: BFO:0000050 UBERON:0004810 ! part of nephron tubule epithelium [Term] id: CL:1000495 name: small intestine goblet cell def: "A goblet cell that is part of the small intestine." [GOC:tfm] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "goblet cell of epithelium of small intestine" EXACT [] synonym: "goblet cell of small intestine" EXACT [] synonym: "small intestinal goblet cell" EXACT [FMA:86929] xref: FMA:86929 is_a: CL:0019031 ! intestine goblet cell is_a: CL:1001598 ! small intestine secretory cell intersection_of: CL:0000160 ! goblet cell intersection_of: BFO:0000050 UBERON:0001902 ! part of epithelium of small intestine property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_1000495" xsd:string {name="small intestine goblet cell on CELLxGENE CellGuide"} property_value: terms:description "Small intestine goblet cells are specialized epithelial cells found in the lining of the small intestine. They are scattered among other columnar cells in the small intestine lining and form a vital part of the intestinal villi—tiny, finger-like projections that boost the absorption of nutrients by increasing the surface area of the intestine. The name ‘goblet cell’ is derived from the cell's distinctive goblet shape, which features a broad apex and a narrow base.\nThe primary function of the small intestine goblet cells is to secrete mucus, a thick and lubricating substance that plays a crucial role in the body's defense mechanisms. This mucus layer, formed through the aggregation of individual mucin glycoproteins produced by goblet cells and secreted from vesicles located near the apical membrane, provides a protective lining that safeguards the epithelial cells of the intestine from corrosive substances and pathogenic organisms. Moreover, the mucin layer helps in the smooth passage of food material along the digestive tract.\nAdditionally, goblet cells in the small intestine contribute significantly to the maintenance of intestinal homeostasis. They actively engage in signal transduction pathways initiated by the native microflora and food antigens, modulating immune responses and preventing inflammation and autoimmunity. The mucus layer also functions as the habitat for beneficial bacteria, thereby facilitating a symbiotic relationship and promoting overall gut health. Any dysfunction or abnormality affecting these cells, such as depletion or hyperplasia, may potentially lead to severe gastrointestinal disorders such as inflammatory bowel disease.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1038/mi.2015.32", xref="DOI:10.1038/s41575-023-00761-8", xref="DOI:10.1111/febs.15731", xref="DOI:10.1111/imr.12182"} [Term] id: CL:1000497 name: kidney cell def: "A cell that is part of a kidney." [] subset: cellxgene_subset subset: human_subset subset: mouse_subset xref: KUPO:0001010 xref: ZFA:0009389 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000255 ! eukaryotic cell intersection_of: CL:0000000 ! cell intersection_of: BFO:0000050 UBERON:0002113 ! part of kidney relationship: BFO:0000050 UBERON:0002113 ! part of kidney [Term] id: CL:1000500 name: kidney interstitial cell def: "A cell that is part of kidney interstitium." [] subset: cellxgene_subset subset: human_subset subset: kidney_upper_slim subset: mouse_subset xref: KUPO:0001013 xref: ZFA:0009390 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:1000497 ! kidney cell is_a: CL:4030031 ! interstitial cell intersection_of: CL:1000497 ! kidney cell intersection_of: BFO:0000050 UBERON:0005215 ! part of kidney interstitium relationship: BFO:0000050 UBERON:0005215 ! part of kidney interstitium [Term] id: CL:1000504 name: kidney medulla cell def: "A cell that is part of a renal medulla." [PMID:22343825] subset: human_subset subset: mouse_subset xref: KUPO:0001017 xref: ZFA:0009391 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:1000497 ! kidney cell intersection_of: CL:1000497 ! kidney cell intersection_of: BFO:0000050 UBERON:0000362 ! part of renal medulla relationship: BFO:0000050 UBERON:0000362 ! part of renal medulla [Term] id: CL:1000505 name: kidney pelvis cell def: "A cell that is part of a renal pelvis." [] subset: human_subset subset: kidney_upper_slim subset: mouse_subset xref: KUPO:0001018 is_a: CL:1000497 ! kidney cell intersection_of: CL:1000497 ! kidney cell intersection_of: BFO:0000050 UBERON:0001224 ! part of renal pelvis relationship: BFO:0000050 UBERON:0001224 ! part of renal pelvis [Term] id: CL:1000507 name: kidney tubule cell def: "A cell that is part of a nephron tubule." [] subset: cellxgene_subset subset: human_subset subset: kidney_upper_slim subset: mouse_subset xref: KUPO:0001020 is_a: CL:1000497 ! kidney cell intersection_of: CL:1000497 ! kidney cell intersection_of: BFO:0000050 UBERON:0001231 ! part of nephron tubule relationship: BFO:0000050 UBERON:0001231 ! part of nephron tubule [Term] id: CL:1000510 name: kidney glomerular epithelial cell def: "Any kidney epithelial cell that is part of some glomerular epithelium." [FBC:Autogenerated] subset: cellxgene_subset subset: human_subset subset: mouse_subset xref: KUPO:0001023 is_a: CL:1000746 ! glomerular cell intersection_of: CL:0002518 ! kidney epithelial cell intersection_of: BFO:0000050 UBERON:0004188 ! part of glomerular epithelium relationship: BFO:0000050 UBERON:0004188 ! part of glomerular epithelium [Term] id: CL:1000546 name: kidney medulla collecting duct epithelial cell def: "An epithelial cell that is part of a renal medulla collecting duct." [] subset: human_subset subset: kidney_upper_slim subset: mouse_subset xref: KUPO:0001060 is_a: CL:1000454 ! kidney collecting duct epithelial cell is_a: CL:1000504 ! kidney medulla cell intersection_of: CL:0000066 ! epithelial cell intersection_of: BFO:0000050 UBERON:0005185 ! part of renal medulla collecting duct relationship: BFO:0000050 UBERON:0005185 ! part of renal medulla collecting duct [Term] id: CL:1000547 name: kidney inner medulla collecting duct epithelial cell def: "An epithelial cell that is part of some inner medullary collecting duct." [] subset: cellxgene_subset subset: human_subset subset: mouse_subset xref: KUPO:0001061 is_a: CL:1000546 ! kidney medulla collecting duct epithelial cell is_a: CL:1000617 ! kidney inner medulla cell intersection_of: CL:0000066 ! epithelial cell intersection_of: BFO:0000050 UBERON:0004205 ! part of inner medullary collecting duct relationship: BFO:0000050 UBERON:0004205 ! part of inner medullary collecting duct [Term] id: CL:1000548 name: kidney outer medulla collecting duct epithelial cell def: "An epithelial cell that is part of an outer medullary collecting duct." [] subset: human_subset subset: mouse_subset xref: KUPO:0001062 is_a: CL:1000546 ! kidney medulla collecting duct epithelial cell is_a: CL:1000616 ! kidney outer medulla cell intersection_of: CL:0000066 ! epithelial cell intersection_of: BFO:0000050 UBERON:0004204 ! part of outer medullary collecting duct relationship: BFO:0000050 UBERON:0004204 ! part of outer medullary collecting duct [Term] id: CL:1000549 name: kidney cortex collecting duct epithelial cell def: "An epithelial cell that is part of a cortical collecting duct." [] subset: cellxgene_subset subset: human_subset subset: mouse_subset xref: KUPO:0001063 is_a: CL:0002584 ! renal cortical epithelial cell is_a: CL:1000454 ! kidney collecting duct epithelial cell intersection_of: CL:0000066 ! epithelial cell intersection_of: BFO:0000050 UBERON:0004203 ! part of cortical collecting duct relationship: BFO:0000050 UBERON:0004203 ! part of cortical collecting duct [Term] id: CL:1000550 name: kidney papillary duct principal epithelial cell def: "Any kidney cell that is part of some papillary duct." [FBC:Autogenerated] subset: human_subset subset: kidney_upper_slim subset: mouse_subset xref: KUPO:0001064 is_a: CL:1001225 ! kidney collecting duct cell intersection_of: CL:1000497 ! kidney cell intersection_of: BFO:0000050 UBERON:0005167 ! part of papillary duct relationship: BFO:0000050 UBERON:0005167 ! part of papillary duct [Term] id: CL:1000596 name: inner renal cortex cell def: "Any kidney cell that is part of some juxtamedullary cortex." [FBC:Autogenerated] subset: human_subset subset: mouse_subset xref: KUPO:0001111 is_a: CL:0002681 ! kidney cortical cell intersection_of: CL:1000497 ! kidney cell intersection_of: BFO:0000050 UBERON:0005271 ! part of juxtamedullary cortex relationship: BFO:0000050 UBERON:0005271 ! part of juxtamedullary cortex [Term] id: CL:1000597 name: papillary tips cell def: "A cell that is part of a tip of a renal papilla." [] subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset xref: KUPO:0001112 is_a: CL:1000505 ! kidney pelvis cell is_a: CL:1000617 ! kidney inner medulla cell intersection_of: CL:1000497 ! kidney cell intersection_of: BFO:0000050 UBERON:0009095 ! part of tip of renal papilla relationship: BFO:0000050 UBERON:0009095 ! part of tip of renal papilla property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:1000600 name: lower urinary tract cell def: "Any cell that is part of some lower urinary tract." [FBC:Autogenerated] subset: human_subset subset: mouse_subset xref: KUPO:0001115 is_a: CL:0000255 ! eukaryotic cell intersection_of: CL:0000000 ! cell intersection_of: BFO:0000050 UBERON:0001556 ! part of lower urinary tract relationship: BFO:0000050 UBERON:0001556 ! part of lower urinary tract [Term] id: CL:1000601 name: ureteral cell def: "Any cell that is part of some ureter." [FBC:Autogenerated] subset: human_subset subset: mouse_subset xref: KUPO:0001116 is_a: CL:0000255 ! eukaryotic cell intersection_of: CL:0000000 ! cell intersection_of: BFO:0000050 UBERON:0000056 ! part of ureter relationship: BFO:0000050 UBERON:0000056 ! part of ureter [Term] id: CL:1000606 name: kidney nerve cell def: "Any neuron that has its soma located in some kidney." [FBC:Autogenerated] subset: human_subset subset: mouse_subset xref: KUPO:0001015 is_a: BFO:0000002 is_a: CL:1000500 ! kidney interstitial cell is_a: CL:2000032 ! peripheral nervous system neuron intersection_of: CL:0000540 ! neuron intersection_of: RO:0002100 UBERON:0002113 ! has soma location kidney relationship: RO:0002100 UBERON:0002113 ! has soma location kidney [Term] id: CL:1000612 name: kidney corpuscule cell def: "Any renal cortical epithelial cell that is part of some renal corpuscle." [FBC:Autogenerated] subset: human_subset subset: kidney_upper_slim subset: mouse_subset xref: KUPO:0001021 is_a: CL:0002584 ! renal cortical epithelial cell is_a: CL:1000449 ! epithelial cell of nephron intersection_of: CL:0002584 ! renal cortical epithelial cell intersection_of: BFO:0000050 UBERON:0001229 ! part of renal corpuscle relationship: BFO:0000050 UBERON:0001229 ! part of renal corpuscle [Term] id: CL:1000615 name: kidney cortex tubule cell def: "Any kidney tubule cell that is part of some renal cortex tubule." [FBC:Autogenerated] subset: cellxgene_subset subset: human_subset subset: mouse_subset xref: KUPO:0001024 is_a: CL:0002584 ! renal cortical epithelial cell is_a: CL:1000449 ! epithelial cell of nephron is_a: CL:1000507 {is_inferred="true"} ! kidney tubule cell intersection_of: CL:1000507 ! kidney tubule cell intersection_of: BFO:0000050 UBERON:0006853 ! part of renal cortex tubule relationship: BFO:0000050 UBERON:0006853 ! part of renal cortex tubule [Term] id: CL:1000616 name: kidney outer medulla cell def: "Any kidney medulla cell that is part of some outer medulla of kidney." [FBC:Autogenerated] subset: human_subset subset: mouse_subset xref: KUPO:0001025 is_a: CL:1000504 {is_inferred="true"} ! kidney medulla cell intersection_of: CL:1000504 ! kidney medulla cell intersection_of: BFO:0000050 UBERON:0001293 ! part of outer medulla of kidney relationship: BFO:0000050 UBERON:0001293 ! part of outer medulla of kidney [Term] id: CL:1000617 name: kidney inner medulla cell def: "Any kidney medulla cell that is part of some inner medulla of kidney." [FBC:Autogenerated] subset: human_subset subset: mouse_subset xref: KUPO:0001026 is_a: CL:1000504 {is_inferred="true"} ! kidney medulla cell intersection_of: CL:1000504 ! kidney medulla cell intersection_of: BFO:0000050 UBERON:0001294 ! part of inner medulla of kidney relationship: BFO:0000050 UBERON:0001294 ! part of inner medulla of kidney [Term] id: CL:1000618 name: juxtaglomerular complex cell def: "Any kidney cortical cell that is part of some juxtaglomerular apparatus." [FBC:Autogenerated] subset: human_subset subset: kidney_upper_slim subset: mouse_subset synonym: "juxtaglomerulus cell" EXACT [GO:0072052] xref: KUPO:0001028 is_a: CL:0002681 {is_inferred="true"} ! kidney cortical cell intersection_of: CL:0002681 ! kidney cortical cell intersection_of: BFO:0000050 UBERON:0002303 ! part of juxtaglomerular apparatus relationship: BFO:0000050 UBERON:0002303 ! part of juxtaglomerular apparatus [Term] id: CL:1000681 name: kidney cortex interstitial cell def: "A cell that is part of an interstitial compartment of a renal cortex." [PMID:18575881] subset: human_subset subset: mouse_subset xref: KUPO:0001091 is_a: CL:0002584 ! renal cortical epithelial cell is_a: CL:1000500 {is_inferred="true"} ! kidney interstitial cell intersection_of: CL:1000500 ! kidney interstitial cell intersection_of: BFO:0000050 UBERON:0005270 ! part of renal cortex interstitium relationship: BFO:0000050 UBERON:0005270 ! part of renal cortex interstitium [Term] id: CL:1000682 name: kidney medulla interstitial cell def: "A cell that is part of an interstitum of a renal medulla." [PMID:21359760] subset: human_subset subset: mouse_subset xref: KUPO:0001092 is_a: CL:1000500 {is_inferred="true"} ! kidney interstitial cell is_a: CL:1000504 {is_inferred="true"} ! kidney medulla cell intersection_of: CL:1000500 ! kidney interstitial cell intersection_of: BFO:0000050 UBERON:0005211 ! part of renal medulla interstitium relationship: BFO:0000050 UBERON:0005211 ! part of renal medulla interstitium [Term] id: CL:1000691 name: kidney interstitial myofibroblast subset: human_reference_atlas subset: human_subset subset: mouse_subset xref: KUPO:0001101 is_a: CL:0000186 ! myofibroblast cell is_a: CL:1000500 ! kidney interstitial cell property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:1000692 name: kidney interstitial fibroblast def: "A fibroblast that is part of an interstitial compartment of a kidney." [PMID:10559635] subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset xref: KUPO:0001102 is_a: CL:0000057 ! fibroblast is_a: CL:1000500 ! kidney interstitial cell intersection_of: CL:0000057 ! fibroblast intersection_of: BFO:0000050 UBERON:0005215 ! part of kidney interstitium property_value: RO:0002175 NCBITaxon:9606 property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_1000692" xsd:string {name="kidney interstitial fibroblast on CELLxGENE CellGuide"} property_value: terms:description "The kidney interstitial fibroblasts are crucial cells found predominantly in the interstitium of the kidneys. These cells play a significant role in maintaining kidney structure and orchestrating key physiological procedures related to kidney function. The interstitium forms a complex network with other cells, capillaries, and the renal tubules, which are crucial for maintaining kidney functions.\nFunctionally, these cells participate in renal homeostasis by synthesizing and secreting vital extracellular matrix (ECM) components, such as collagen, proteoglycan, and fibronectin, which contribute to the structural integrity of the kidneys. Additionally, these fibroblasts provide supportive tissues to nephrons (structural and functional units of kidneys), help in regulating fluid and electrolyte balance, along with providing an arena for immune response in case of any infection or damage. They are also integral to the regulation of kidney blood flow and maintenance of tubular structures by stabilizing capillaries through synthesis of angiogenic factors.\nUnder pathological conditions, such as renal fibrosis, kidney interstitial fibroblasts can transform into myofibroblasts, which speed up the production and deposition of extracellular matrix proteins. This overproduction can lead to scar formation and affect the kidney's functionality, often leading to a chronic and progressive loss of renal function.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1007/s00418-008-0452-5", xref="DOI:10.1038/s41598-019-38691-8", xref="DOI:10.1111/j.1365-2613.2011.00764.x", xref="DOI:10.1152/ajprenal.00284.2023", xref="DOI:10.3389/fphys.2016.00061"} [Term] id: CL:1000693 name: kidney interstitial fibrocyte def: "A stromal cell that infiltrates and resides in the kidney interstitium following injury, characterized by the co-expression of CD45 with mesenchymal markers including α-SMA, and collagen I in humans (Kim et al., 2023). This cell originates from circulating monocyte-derived fibrocytes. It produces extracellular matrix components, contributing to renal fibrosis by potentially differentiating into myofibroblasts upon infiltration into injured kidneys (Sun et al., 2016). Migration into the kidney is dependent on chemokine receptor signaling, particularly CCR2 in mice (Reich et al., 2013)." [PMID:23486523, PMID:27262400, PMID:35703942] subset: human_subset subset: mouse_subset synonym: "renal fibrocyte" BROAD [PMID:35703942] xref: KUPO:0001103 is_a: CL:0000499 ! stromal cell is_a: CL:1000500 ! kidney interstitial cell relationship: RO:0002202 CL:0000135 ! develops from circulating fibrocyte [Term] id: CL:1000695 name: kidney interstitial alternatively activated macrophage subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset xref: KUPO:0001106 is_a: CL:0000890 ! M2 macrophage is_a: CL:1000500 ! kidney interstitial cell property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:1000696 name: kidney interstitial inflammatory macrophage subset: human_subset subset: mouse_subset xref: KUPO:0001107 is_a: CL:0000863 ! M1 macrophage is_a: CL:1000500 ! kidney interstitial cell [Term] id: CL:1000697 name: kidney interstitial suppressor macrophage subset: human_subset subset: mouse_subset xref: KUPO:0001108 is_a: CL:0000862 ! suppressor macrophage is_a: CL:1000500 ! kidney interstitial cell [Term] id: CL:1000698 name: kidney resident macrophage def: "A tissue-resident macrophage that is part of some kidney." [] subset: cellxgene_subset subset: human_subset subset: mouse_subset xref: KUPO:0001109 is_a: CL:0000864 ! tissue-resident macrophage is_a: CL:1000500 ! kidney interstitial cell property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_1000698" xsd:string {name="kidney resident macrophage on CELLxGENE CellGuide"} property_value: terms:description "Kidney resident macrophages are a heterogeneous population of immune cell found in the cortex and medullary regions of the kidney as well as within and surround the glomeruli. Their primary role involves maintaining homeostasis and immune surveillance in the kidney microenvironment, defending against ascending urinary infections. Beyond traditional macrophage roles such as phagocytosis and antigen presentation, kidney resident macrophages also contribute significantly to the response to kidney injury including tissue repair and angiogenesis.\nUnder normal physiological conditions, kidney resident macrophages work to maintain the balance of the kidney's microenvironment by removing dead cells, pathogens and cellular debris, to limit inflammation and tissue damage. They are ‘professional’ phagocytes, clearing pathogens and debris by engulfing and digesting these harmful materials. Moreover, they are capable of presenting antigens to other immune cells, which aids in the activation of the adaptive immune response. \nKidney resident macrophages show a high degree of plasticity: in response to environmental stimuli they change their morphology and cell surface markers. For example, in response to acute injury, some macrophages adopt a pro-inflammatory phenotype and augment tissue damage; once the injury stimulus is removed, they may change to mediate tissue repair. \nWhile kidney macrophages contribute to wound healing, tissue repair and regeneration by producing key growth factors and cytokines that stimulate cell proliferation, collagen production, and blood vessel formation, dysregulation in their activity can also lead to progressive inflammation and fibrosis, common features in chronic kidney disease.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1016/bs.ircmb.2022.01.005", xref="DOI:10.1172/jci.insight.161078", xref="DOI:10.3389/fimmu.2021.681748", xref="DOI:10.3389/fphys.2017.00837"} [Term] id: CL:1000699 name: kidney resident dendritic cell def: "A resident-dendritic cell that is part of a kidney." [PMID:25266210] subset: human_subset subset: mouse_subset xref: KUPO:0001110 is_a: CL:0001007 ! interstitial dendritic cell is_a: CL:1000500 ! kidney interstitial cell [Term] id: CL:1000702 name: kidney pelvis smooth muscle cell def: "Any smooth muscle cell that is part of some kidney pelvis smooth muscle." [FBC:Autogenerated] subset: human_subset subset: mouse_subset xref: KUPO:0001113 is_a: CL:0000192 {is_inferred="true"} ! smooth muscle cell is_a: CL:1000505 {is_inferred="true"} ! kidney pelvis cell intersection_of: CL:0000192 ! smooth muscle cell intersection_of: BFO:0000050 UBERON:0004227 ! part of kidney pelvis smooth muscle relationship: BFO:0000050 UBERON:0004227 ! part of kidney pelvis smooth muscle [Term] id: CL:1000703 name: kidney pelvis urothelial cell def: "Any kidney epithelial cell that is part of some kidney pelvis urothelium." [FBC:Autogenerated] subset: cellxgene_subset subset: human_subset subset: mouse_subset xref: KUPO:0001114 is_a: CL:0000731 ! urothelial cell is_a: CL:0002518 {is_inferred="true"} ! kidney epithelial cell is_a: CL:1000505 {is_inferred="true"} ! kidney pelvis cell intersection_of: CL:0002518 ! kidney epithelial cell intersection_of: BFO:0000050 UBERON:0004788 ! part of kidney pelvis urothelium relationship: BFO:0000050 UBERON:0004788 ! part of kidney pelvis urothelium [Term] id: CL:1000706 name: ureter urothelial cell def: "A urothelial cell that is part of the urothelium of ureter." [PMID:36180582] subset: human_subset subset: mouse_subset xref: KUPO:0001117 is_a: CL:0000731 ! urothelial cell is_a: CL:1000601 ! ureteral cell intersection_of: CL:0000731 ! urothelial cell intersection_of: BFO:0000050 UBERON:0001254 ! part of urothelium of ureter relationship: BFO:0000050 UBERON:0001254 ! part of urothelium of ureter [Term] id: CL:1000708 name: ureter adventitial cell def: "Any ureteral cell that is part of some adventitia of ureter." [FBC:Autogenerated] subset: human_reference_atlas subset: human_subset subset: mouse_subset xref: KUPO:0001119 is_a: CL:0000115 ! endothelial cell is_a: CL:0002503 ! adventitial cell is_a: CL:1000601 {is_inferred="true"} ! ureteral cell intersection_of: CL:1000601 ! ureteral cell intersection_of: BFO:0000050 UBERON:0001252 ! part of adventitia of ureter relationship: BFO:0000050 UBERON:0001252 ! part of adventitia of ureter property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:1000714 name: kidney cortex collecting duct principal cell def: "Any renal principal cell that is part of some cortical collecting duct." [FBC:Autogenerated] subset: human_reference_atlas subset: human_subset subset: mouse_subset xref: KUPO:0001130 is_a: CL:1000549 {is_inferred="true"} ! kidney cortex collecting duct epithelial cell is_a: CL:1001431 ! kidney collecting duct principal cell intersection_of: CL:0005009 ! renal principal cell intersection_of: BFO:0000050 UBERON:0004203 ! part of cortical collecting duct property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/2d-ftu/kidney-cortical-collecting-duct/v1.3/assets/2d-ftu-kidney-cortical-collecting-duct.png" xsd:string {terms:licence="http://creativecommons.org/licenses/by/4.0/", xref="doi:10.48539/HBM483.MXQP.399"} property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/2d-ftu/kidney-nephron/v1.2/assets/2d-ftu-kidney-nephron.png" xsd:string {terms:licence="http://creativecommons.org/licenses/by/4.0/", xref="doi:10.48539/HBM927.DQNW.448"} property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:1000715 name: kidney cortex collecting duct intercalated cell def: "Any renal intercalated cell that is part of some cortical collecting duct." [FBC:Autogenerated] subset: human_reference_atlas subset: human_subset subset: mouse_subset xref: KUPO:0001131 is_a: CL:1000549 {is_inferred="true"} ! kidney cortex collecting duct epithelial cell is_a: CL:1001432 ! kidney collecting duct intercalated cell intersection_of: CL:0005010 ! renal intercalated cell intersection_of: BFO:0000050 UBERON:0004203 ! part of cortical collecting duct property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:1000716 name: kidney outer medulla collecting duct principal cell def: "Principal cell that is part of some outer medullary collecting duct. It is known in some mammalian species that this cell may express the epithelial sodium channel (ENaC)." [PMID:25632105] subset: human_reference_atlas subset: human_subset subset: mouse_subset xref: KUPO:0001132 is_a: CL:1000548 {is_inferred="true"} ! kidney outer medulla collecting duct epithelial cell is_a: CL:1001431 ! kidney collecting duct principal cell intersection_of: CL:0005009 ! renal principal cell intersection_of: BFO:0000050 UBERON:0004204 ! part of outer medullary collecting duct property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/2d-ftu/kidney-nephron/v1.2/assets/2d-ftu-kidney-nephron.png" xsd:string {terms:licence="http://creativecommons.org/licenses/by/4.0/", xref="doi:10.48539/HBM927.DQNW.448"} property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/2d-ftu/kidney-outer-medullary-collecting-duct/v1.2/assets/2d-ftu-kidney-outer-medullary-collecting-duct.png" xsd:string {terms:licence="http://creativecommons.org/licenses/by/4.0/", xref="doi:10.48539/HBM724.KFSK.483"} property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:1000717 name: kidney outer medulla collecting duct intercalated cell def: "Intercalated cell that is part of some outer medullary collecting duct. It is known in some mammalian species that this cell may contribute in the maintenance of acid/base homeostasis." [PMID:25632105] subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset xref: KUPO:0001133 is_a: CL:1000548 {is_inferred="true"} ! kidney outer medulla collecting duct epithelial cell is_a: CL:1001432 ! kidney collecting duct intercalated cell intersection_of: CL:0005010 ! renal intercalated cell intersection_of: BFO:0000050 UBERON:0004204 ! part of outer medullary collecting duct property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/2d-ftu/kidney-outer-medullary-collecting-duct/v1.2/assets/2d-ftu-kidney-outer-medullary-collecting-duct.png" xsd:string {terms:licence="http://creativecommons.org/licenses/by/4.0/", xref="doi:10.48539/HBM724.KFSK.483"} property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:1000718 name: kidney inner medulla collecting duct principal cell def: "Any renal principal cell that is part of some inner medullary collecting duct." [FBC:Autogenerated] subset: human_reference_atlas subset: human_subset subset: mouse_subset xref: KUPO:0001134 is_a: CL:1000547 {is_inferred="true"} ! kidney inner medulla collecting duct epithelial cell is_a: CL:1001431 ! kidney collecting duct principal cell intersection_of: CL:0005009 ! renal principal cell intersection_of: BFO:0000050 UBERON:0004205 ! part of inner medullary collecting duct property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/2d-ftu/kidney-inner-medullary-collecting-duct/v1.2/assets/2d-ftu-kidney-inner-medullary-collecting-duct.png" xsd:string {terms:licence="http://creativecommons.org/licenses/by/4.0/", xref="doi:10.48539/HBM268.TNSF.557"} property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/2d-ftu/kidney-nephron/v1.2/assets/2d-ftu-kidney-nephron.png" xsd:string {terms:licence="http://creativecommons.org/licenses/by/4.0/", xref="doi:10.48539/HBM927.DQNW.448"} property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:1000719 name: kidney inner medulla collecting duct intercalated cell def: "Any renal intercalated cell that is part of some inner medullary collecting duct." [FBC:Autogenerated] subset: human_subset subset: mouse_subset xref: KUPO:0001135 is_a: CL:1000547 {is_inferred="true"} ! kidney inner medulla collecting duct epithelial cell is_a: CL:1001432 ! kidney collecting duct intercalated cell intersection_of: CL:0005010 ! renal intercalated cell intersection_of: BFO:0000050 UBERON:0004205 ! part of inner medullary collecting duct [Term] id: CL:1000720 name: kidney papillary duct intercalated cell def: "Any renal intercalated cell that is part of some papillary duct." [FBC:Autogenerated] subset: human_subset subset: mouse_subset xref: KUPO:0001136 is_a: CL:1000550 {is_inferred="true"} ! kidney papillary duct principal epithelial cell is_a: CL:1001432 ! kidney collecting duct intercalated cell intersection_of: CL:0005010 ! renal intercalated cell intersection_of: BFO:0000050 UBERON:0005167 ! part of papillary duct [Term] id: CL:1000721 name: kidney papillary duct principal cell def: "Any renal principal cell that is part of some papillary duct." [FBC:Autogenerated] subset: human_subset subset: mouse_subset xref: KUPO:0001137 is_a: CL:1000550 {is_inferred="true"} ! kidney papillary duct principal epithelial cell is_a: CL:1001431 ! kidney collecting duct principal cell intersection_of: CL:0005009 ! renal principal cell intersection_of: BFO:0000050 UBERON:0005167 ! part of papillary duct [Term] id: CL:1000742 name: glomerular mesangial cell def: "A mesangial cell located among the glomerular capillaries in a renal corpuscle." [https://doi.org/10.1152/physrev.1998.78.3.723, Wikipedia:Intraglomerular_mesangial_cell] comment: Like smooth muscle, a glomerular mesangial cell is contractile and possesses the filaments actin and myosin. The contractile mechanism is also similar to that of smooth muscle, with Ca2+/calmodulin-activated myosin light-chain kinase instigating myosin-actin cross-bridge cycling. Mesangial cell phagocytosis of apoptotic neutrophils involves a novel CD36-independent, alpha(v)beta3/TSP-mediated mechanism that is uncoupled from chemokine secretion, emphasizing the injury-limiting potential of mesangial cell phagocytosis of apoptotic cells. {xref="https://doi.org/10.1152/physrev.1998.78.3.723", xref="PMID:9127003"} subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "intraglomerular mesangial cell" EXACT [CL:cjm] xref: KUPO:0001032 is_a: CL:0000234 ! phagocyte is_a: CL:0000650 ! mesangial cell is_a: CL:1000746 ! glomerular cell relationship: BFO:0000050 UBERON:0002320 ! part of glomerular mesangium relationship: RO:0002215 GO:0070252 ! capable of actin-mediated cell contraction property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/2d-ftu/kidney-renal-corpuscle/v1.2/assets/2d-ftu-kidney-renal-corpuscle.png" xsd:string {terms:licence="http://creativecommons.org/licenses/by/4.0/", xref="doi:10.48539/HBM778.SHGJ.294"} property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:1000746 name: glomerular cell def: "Any kidney corpuscule cell that is part of some renal glomerulus." [FBC:Autogenerated] subset: human_subset subset: mouse_subset xref: KUPO:0001036 is_a: CL:1000612 ! kidney corpuscule cell intersection_of: CL:1000612 ! kidney corpuscule cell intersection_of: BFO:0000050 UBERON:0000074 ! part of renal glomerulus relationship: BFO:0000050 UBERON:0000074 ! part of renal glomerulus [Term] id: CL:1000768 name: kidney connecting tubule epithelial cell def: "Any nephron tubule epithelial cell that is part of some renal connecting tubule." [FBC:Autogenerated] subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: kidney_upper_slim subset: mouse_subset xref: KUPO:0001058 is_a: CL:1000494 {is_inferred="true"} ! nephron tubule epithelial cell is_a: CL:1000615 ! kidney cortex tubule cell intersection_of: CL:1000494 ! nephron tubule epithelial cell intersection_of: BFO:0000050 UBERON:0005097 ! part of renal connecting tubule relationship: BFO:0000050 UBERON:0005097 ! part of renal connecting tubule property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/2d-ftu/kidney-nephron/v1.2/assets/2d-ftu-kidney-nephron.png" xsd:string {terms:licence="http://creativecommons.org/licenses/by/4.0/", xref="doi:10.48539/HBM927.DQNW.448"} property_value: RO:0002175 NCBITaxon:9606 property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_1000768" xsd:string {name="kidney connecting tubule epithelial cell on CELLxGENE CellGuide"} property_value: terms:description "Kidney connecting tubule epithelial cells are found in collecting duct system of the kidney, specifically in at the interconnection segment between the nephron and the collecting ducts. The epithelial cells lining the connecting tubule are crucial for the journey of filtrate before it empties into urine-collecting ducts and therefore play a critical role in maintaining the body’s fluid and electrolyte balance.\nOne of the principal functions of connecting tubule epithelial cells involves the selective reabsorption and secretion of various solutes. This reabsorption process includes critical regulatory electrolytes such as sodium ions (Na+), chloride ions (Cl-), and bicarbonate ions (HCO3-), thus playing a role in the regulation of the acid-base homeostasis. Their function also involves the secretion of potassium ions (K+) into the renal tubular fluid.\nThe connecting tubule epithelial cells are primarily intercalated cells, which can be categorized into two types according to their specific functions: type A intercalated cells, which secrete acid, and the type B intercalated cells, which secrete base (bicarbonate) and reabsorb chloride. By regulating the concentrations of these ions, as well as reabsorption of water, connecting tubule epithelial cells contribute substantively to maintaining the body's electrolyte levels, pH balance, and overall homeostasis.\nIn addition to intercalating cells, the collecting duct system also has principal cells, which are characterized by the expression of the water channel AQP2. AQP2-expressing cells have also been identified in connecting tubules, but there is some controversy whether these represent a unique cell type as there are some morphologic differences compared with principal cells.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1002/cphy.c110052", xref="DOI:10.1007/s00418-021-02033-5", xref="DOI:10.1097/MNH.0b013e32820ac850", xref="DOI:10.1681/ASN.2019040415", xref="DOI:10.23876/j.krcp.2017.36.4.305"} [Term] id: CL:1000803 name: kidney inner medulla interstitial cell def: "A cell that is part of an interstitial compartment of an inner renal medulla." [PMID:21359760] subset: human_subset subset: mouse_subset xref: KUPO:0001093 is_a: CL:1000617 {is_inferred="true"} ! kidney inner medulla cell is_a: CL:1000682 {is_inferred="true"} ! kidney medulla interstitial cell intersection_of: CL:1000682 ! kidney medulla interstitial cell intersection_of: BFO:0000050 UBERON:0005214 ! part of inner renal medulla interstitium relationship: BFO:0000050 UBERON:0005214 ! part of inner renal medulla interstitium [Term] id: CL:1000804 name: kidney outer medulla interstitial cell def: "A kidney cell that is part of an interstitial compartment of an outer renal medulla." [PMID:8694267] subset: human_subset subset: mouse_subset xref: KUPO:0001094 is_a: CL:1000616 {is_inferred="true"} ! kidney outer medulla cell is_a: CL:1000682 {is_inferred="true"} ! kidney medulla interstitial cell intersection_of: CL:1000682 ! kidney medulla interstitial cell intersection_of: BFO:0000050 UBERON:0005213 ! part of outer renal medulla interstitium relationship: BFO:0000050 UBERON:0005213 ! part of outer renal medulla interstitium [Term] id: CL:1000838 name: kidney proximal convoluted tubule epithelial cell def: "Any epithelial cell of proximal tubule that is part of some proximal convoluted tubule and has part some brush border." [FBC:Autogenerated] subset: cellxgene_subset subset: human_subset subset: mouse_subset xref: KUPO:0001045 is_a: CL:0002307 ! brush border cell of the proximal tubule intersection_of: CL:0002306 ! epithelial cell of proximal tubule intersection_of: BFO:0000050 UBERON:0001287 ! part of proximal convoluted tubule intersection_of: BFO:0000051 GO:0005903 ! has part brush border relationship: BFO:0000050 UBERON:0001287 ! part of proximal convoluted tubule property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_1000838" xsd:string {name="kidney proximal convoluted tubule epithelial cell on CELLxGENE CellGuide"} property_value: terms:description "Kidney proximal convoluted tubule epithelial cells line the most voluminous part of the kidney's nephron, the proximal convoluted tubule, located in the cortex of the kidney. These cells are primarily involved in reabsorption and secretion processes, key functions that facilitate homeostasis within the body.\nProximal convoluted tubule epithelial cells extensively function in the reabsorption process to a greater degree than their counterparts in the proximal straight tubule. Approximately two-thirds of filtrated sodium and water, nearly all nutrient sugars and amino acids, and a significant portion of bicarbonates pass through the proximal convoluted tubule, are effectively absorbed by the epithelial cells, and reenter the bodily circulation. By absorbing bicarbonates and secreting protons into the tubular fluid, proximal convoluted tubule epithelial cells also contribute to the pH regulation in the body .\nIn addition to reabsorption, proximal convoluted tubule epithelial cells also play a critical role in the excretion of waste metabolites and xenobiotics. These cells possess a range of transporters that secrete metabolic end products and certain drugs, hence aiding in their elimination. This function underlines their importance for body detoxification.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1002/cphy.c110060", xref="DOI:10.1146/annurev-physiol-052521-121841", xref="DOI:10.1159/000092212", xref="DOI:10.1681/ASN.2019040415"} [Term] id: CL:1000839 name: kidney proximal straight tubule epithelial cell def: "Any epithelial cell of proximal tubule that is part of some proximal straight tubule." [FBC:Autogenerated] subset: cellxgene_subset subset: human_subset subset: mouse_subset xref: KUPO:0001046 is_a: CL:0002306 {is_inferred="true"} ! epithelial cell of proximal tubule is_a: CL:1000616 {is_inferred="true"} ! kidney outer medulla cell is_a: CL:1001021 ! kidney loop of Henle descending limb epithelial cell intersection_of: CL:0002306 ! epithelial cell of proximal tubule intersection_of: BFO:0000050 UBERON:0001290 ! part of proximal straight tubule relationship: BFO:0000050 UBERON:0001290 ! part of proximal straight tubule property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_1000839" xsd:string {name="kidney proximal straight tubule epithelial cell on CELLxGENE CellGuide"} property_value: terms:description "Kidney proximal straight tubule epithelial cells line the straight portion of the proximal tubule of the nephron, extending from the cortical medullary ray into the outer stripe of the outer medulla. They are characterized by a brush border of dense microvilli on their apical surface, enhancing the cell's surface area and aiding reabsorption, though reabsorption occurs more heavily in the proximal convoluted tubule preceding the straight portion of the tubule.\nThe primary function of the kidney proximal straight tubule epithelial cells is to reabsorb the filtrate that the kidney produces, which includes glucose, sodium, and water. The reabsorption occurs through both passive and active transport methods. These cells exhibit enzyme-rich microvilli that also absorb small proteins and peptides. Consequently, they are involved in the regulation of plasma levels of various substances, including glucose, amino acids, and electrolytes, and maintain the body's pH homeostasis by secreting H+ ions into the urine and absorbing bicarbonate ions.\nThese cells are also reported to be involved in drug metabolism. Many drugs are filtered from the blood by the kidneys and subsequently reabsorbed by the kidney proximal tubule epithelial cells back into the bloodstream. Furthermore, these cells play a significant role in the progression of kidney diseases. For example, in diabetic nephropathy and acute kidney injury, kidney proximal straight tubule epithelial cells can undergo cellular changes and result in malfunctions such as reduced reabsorption and increased excretion.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1002/cphy.c110061", xref="DOI:10.1038/nrd4461", xref="DOI:10.1146/annurev-physiol-052521-121841", xref="DOI:10.1681/ASN.2019040415", xref="DOI:10.2215/CJN.10391012"} [Term] id: CL:1000849 name: kidney distal convoluted tubule epithelial cell def: "Any epithelial cell of distal tubule that is part of some distal convoluted tubule." [FBC:Autogenerated] subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: kidney_upper_slim subset: mouse_subset xref: KUPO:0001056 is_a: CL:0002305 {is_inferred="true"} ! epithelial cell of distal tubule intersection_of: CL:0002305 ! epithelial cell of distal tubule intersection_of: BFO:0000050 UBERON:0001292 ! part of distal convoluted tubule relationship: BFO:0000050 UBERON:0001292 ! part of distal convoluted tubule property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/2d-ftu/kidney-nephron/v1.2/assets/2d-ftu-kidney-nephron.png" xsd:string {terms:licence="http://creativecommons.org/licenses/by/4.0/", xref="doi:10.48539/HBM927.DQNW.448"} property_value: RO:0002175 NCBITaxon:9606 property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_1000849" xsd:string {name="kidney distal convoluted tubule epithelial cell on CELLxGENE CellGuide"} property_value: terms:description "Kidney distal convoluted tubule epithelial cells, often referred to simply as distal convoluted tubule (DCT) cells, constitute a significant portion of the nephron -- the functional building unit of the kidney involved in filtration and reabsorption of substances from blood. The DCT epithelial cells form lining of the distal convoluted tubule, a segment of the nephron located after the loop of Henle and before the collecting tubule. These cells are characterized by unique morphological features such as small size, low height and fewer microvilli compared to proximal convoluted tubule epithelial cells. \nThese cells perform a host of vital functions contributing to the regulation of extracellular fluid volume and electrolyte balance, blood pressure and pH. While the DCT is less prominent in water and sodium reabsorption compared to the proximal tubule and the loop of Henle, it plays a crucial role in fine-tuning the process. DCT epithelial cells are responsible for the final adjustments of sodium, potassium and calcium reabsorption, thereby affecting overall fluid and electrolyte balance, blood pressure regulation and bone health. The reabsorption process is regulated by hormones including aldosterone and parathyroid hormone.\nThe distal convoluted tubule (DCT) also plays a significant role in acid-base homeostasis by secreting protons (H+) into the tubular fluid and reabsorbing bicarbonate ions (HCO3-), thus regulating the pH of the blood. The ability of DCT cells to adjust urine concentration plays a part in maintaining the body’s pH balance and preventing conditions like acidosis or alkalosis. In summary, kidney distal convoluted tubule epithelial cells perform functions that are crucial to maintaining body's homeostasis.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1002/cphy.c140002", xref="DOI:10.1007/s40620-021-01032-y", xref="DOI:10.1152/physrev.2000.80.1.277", xref="DOI:10.1681/ASN.2019040415", xref="DOI:10.2215/CJN.05920613"} [Term] id: CL:1000850 name: macula densa epithelial cell def: "An epithelial cell that is part of the macula densa, characterized by a tightly packed arrangement, apically positioned nuclei, and prominent primary cilia, creating a distinctive 'dense spot' appearance under microscopy. It is involved in regulating renal blood flow, glomerular filtration rate, and renin release." [PMID:33491562, PMID:36142420, Wikipedia:Macula_densa] subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "macula densa cell" EXACT [PMID:33491562] xref: KUPO:0001057 is_a: CL:0000067 ! ciliated epithelial cell is_a: CL:0002305 ! epithelial cell of distal tubule is_a: CL:1000618 {is_inferred="true"} ! juxtaglomerular complex cell intersection_of: CL:0000066 ! epithelial cell intersection_of: BFO:0000050 UBERON:0002335 ! part of macula densa relationship: BFO:0000050 UBERON:0002335 ! part of macula densa relationship: BFO:0000051 GO:0097730 ! has part non-motile cilium relationship: RO:0002215 GO:0003093 ! capable of regulation of glomerular filtration relationship: RO:0002215 GO:1900133 ! capable of regulation of renin secretion into blood stream property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/2d-ftu/kidney-nephron/v1.2/assets/2d-ftu-kidney-nephron.png" xsd:string {terms:licence="http://creativecommons.org/licenses/by/4.0/", xref="doi:10.48539/HBM927.DQNW.448"} property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/2d-ftu/kidney-renal-corpuscle/v1.2/assets/2d-ftu-kidney-renal-corpuscle.png" xsd:string {terms:licence="http://creativecommons.org/licenses/by/4.0/", xref="doi:10.48539/HBM778.SHGJ.294"} property_value: RO:0002175 NCBITaxon:9606 property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_1000850" xsd:string {name="macula densa epithelial cell on CELLxGENE CellGuide"} property_value: terms:description "Macula densa epithelial cells, as part of the complex nephron structure, play a crucial role in kidney function. These cells, which make up the macula densa, help regulate blood pressure and the filtration rate of the glomerulus by sensing sodium chloride amounts in the kidney tubules. Found where the thick ascending limb of the Loop of Henle touches the afferent arteriole, macula densa epithelial cells are positioned in an optimal location to monitor and respond to changes in the filtrate composition.\nThese cells maintain intraglomerular homeostasis. When the sodium chloride concentration is high, macula densa cells respond by secreting adenosine and vasoconstricting the afferent arteriole to decrease the glomerular filtration rate. Conversely, if the sodium chloride concentration in the filtrate is low, the production and release of nitric oxide cause vasodilation to enhance the glomerular filtration rate. \nMacula densa epithelial cells also have a role in tubuloglomerular feedback mechanisms, an essential autoregulatory renal response. They send feedback to the glomerular mesangial cells, allowing constriction or relaxation of the afferent arteriole as needed depending on the content of the filtrate.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1073/pnas.0736323100", xref="DOI:10.1146/annurev-physiol-052521-121841", xref="DOI:10.1161/HYPERTENSIONAHA.115.04739", xref="DOI:10.1681/ASN.2009070759", xref="DOI:10.1681/ASN.2015050515"} [Term] id: CL:1000854 name: kidney blood vessel cell def: "A blood vessel cell that is part of a kidney." [PMID:34843404] subset: human_subset subset: mouse_subset xref: KUPO:0001014 is_a: BFO:0000002 is_a: CL:1000504 {is_inferred="true"} ! kidney medulla cell intersection_of: CL:0000000 ! cell intersection_of: BFO:0000050 UBERON:0003517 ! part of kidney blood vessel relationship: BFO:0000050 UBERON:0003517 ! part of kidney blood vessel relationship: RO:0000056 GO:0008015 ! participates in blood circulation [Term] id: CL:1000891 name: kidney arterial blood vessel cell def: "Any kidney blood vessel cell that is part of some kidney arterial blood vessel." [FBC:Autogenerated] subset: cellxgene_subset subset: human_subset subset: kidney_upper_slim subset: mouse_subset xref: KUPO:0001029 is_a: CL:1000854 {is_inferred="true"} ! kidney blood vessel cell intersection_of: CL:1000854 ! kidney blood vessel cell intersection_of: BFO:0000050 UBERON:0003644 ! part of kidney arterial blood vessel relationship: BFO:0000050 UBERON:0003644 ! part of kidney arterial blood vessel [Term] id: CL:1000892 name: kidney capillary endothelial cell def: "An endothelial cell that is part of the capillary of the kidney." [] subset: cellxgene_subset subset: human_subset subset: kidney_upper_slim subset: mouse_subset xref: KUPO:0001030 is_a: CL:0002144 ! capillary endothelial cell is_a: CL:1000854 ! kidney blood vessel cell intersection_of: CL:0000115 ! endothelial cell intersection_of: BFO:0000050 UBERON:0003527 ! part of kidney capillary relationship: BFO:0000050 UBERON:0003527 ! part of kidney capillary property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_1000892" xsd:string {name="kidney capillary endothelial cell on CELLxGENE CellGuide"} property_value: terms:description "Kidney capillary endothelial cells form the innermost lining of the capillaries and microvessels within kidneys, including those lining the glomerular capillaries and the vasa recta. Each cell exhibits a unique array of adhesion molecules, receptors, and secreted mediators which interact with circulating blood cells and solutes. \nOne of the key functions of kidney capillary endothelial cells is enabling filtration, reabsorption, secretion, and excretion – the crucial steps in the formation of urine. In the glomerulus, these cells form a collaborative relationship with the podocytes to constitute the glomerular filtration barrier; here, the ultra-thin endothelial cells create a wall through which water and small solutes pass while retaining larger proteins and molecules within the bloodstream. This permits the rapid and selective filtration of plasma, a primary aspect of the kidney's role in waste clearance and fluid, electrolyte, and acid-base homeostasis.\nKidney capillary endothelial cells also conduct multiple homeostatic roles, such as vasomotor control, fibrinolysis, platelet adhesion, inflammation, and coagulation. They also play a crucial role in responding to renal injury by participating in fibrogenesis, an initial response following acute kidney injury. The endothelial cells spearhead angiogenesis (new blood vessel formation) and the repair and regeneration of renal tissue, thereby enhancing the survival function of the kidney itself. Furthermore, factors secreted by kidney capillary endothelial cells also help control the growth and differentiation of other types of renal cells.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1016/j.biocel.2010.05.015", xref="DOI:10.1038/s41581-021-00411-9", xref="DOI:10.1038/sj.ki.5002312", xref="DOI:10.1111/j.1523-1755.2005.00260.x"} [Term] id: CL:1000893 name: kidney venous blood vessel cell def: "Any kidney blood vessel cell that is part of some renal vein." [FBC:Autogenerated] subset: human_subset subset: kidney_upper_slim subset: mouse_subset xref: KUPO:0001031 is_a: CL:1000854 {is_inferred="true"} ! kidney blood vessel cell intersection_of: CL:1000854 ! kidney blood vessel cell intersection_of: BFO:0000050 UBERON:0001140 ! part of renal vein relationship: BFO:0000050 UBERON:0001140 ! part of renal vein [Term] id: CL:1000909 name: kidney loop of Henle epithelial cell def: "Any nephron tubule epithelial cell that is part of some loop of Henle." [FBC:Autogenerated] subset: cellxgene_subset subset: human_subset subset: mouse_subset xref: KUPO:0001047 is_a: CL:1000494 {is_inferred="true"} ! nephron tubule epithelial cell intersection_of: CL:1000494 ! nephron tubule epithelial cell intersection_of: BFO:0000050 UBERON:0001288 ! part of loop of Henle relationship: BFO:0000050 UBERON:0001288 ! part of loop of Henle [Term] id: CL:1000979 name: ureter smooth muscle cell def: "Any smooth muscle cell that is part of some muscular coat of ureter." [FBC:Autogenerated] subset: human_reference_atlas subset: human_subset subset: mouse_subset xref: KUPO:0001118 is_a: CL:0000192 {is_inferred="true"} ! smooth muscle cell is_a: CL:1000601 {is_inferred="true"} ! ureteral cell intersection_of: CL:0000192 ! smooth muscle cell intersection_of: BFO:0000050 UBERON:0006855 ! part of muscular coat of ureter relationship: BFO:0000050 UBERON:0006855 ! part of muscular coat of ureter property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:1001005 name: glomerular capillary endothelial cell def: "An endothelial cell that is part of the glomerular capillary of the kidney." [] subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset xref: KUPO:0001037 is_a: CL:0002188 ! glomerular endothelial cell is_a: CL:1000892 ! kidney capillary endothelial cell intersection_of: CL:1000892 ! kidney capillary endothelial cell intersection_of: BFO:0000050 UBERON:0004294 ! part of glomerular capillary endothelium relationship: BFO:0000050 UBERON:0004294 ! part of glomerular capillary endothelium property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/2d-ftu/kidney-renal-corpuscle/v1.2/assets/2d-ftu-kidney-renal-corpuscle.png" xsd:string {terms:licence="http://creativecommons.org/licenses/by/4.0/", xref="doi:10.48539/HBM778.SHGJ.294"} property_value: RO:0002175 NCBITaxon:9606 property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_1001005" xsd:string {name="glomerular capillary endothelial cell on CELLxGENE CellGuide"} property_value: terms:description "The glomerular capillary endothelial cell comprises an intrinsic component of the glomerulus in the kidney. Glomeruli contain a network of capillaries where the first step of blood filtration takes place, with glomerular capillary endothelial cells acting as an integral part of this process. Unlike regular endothelial cells that line the vasculature, unique fenestrations (openings) characterize these cells, allowing for enhanced permeability and filtration efficacy.\nTogether with the glomerular basement membrane and podocytes, the glomerular endothelial cells form the glomerular filtration barrier, which is responsible for blood filtration and therefore critical for removal of waste products, such as urea and creatinine, and excess substances, such as glucose and ions, from the bloodstream. The glomerular capillary endothelial cells' fenestrations permit the free flow of a variety of particles, barring larger, negatively charged proteins like serum albumin, enabling the formation of an ultrafiltrate. This ultrafiltrate is the primitive form of urine, which then passes through the proximal tubule for further processing and ultimately helps maintain systemic fluid and electrolyte balance.\nMoreover, the glomerular capillary endothelial cells are also believed to play a crucial role in renal pathologies. Any compromise to their structural integrity or functional performance can lead to kidney diseases, including but not limited to, diabetic nephropathy and glomerulonephritis. For instance, in diabetes, persistent hyperglycemia can injure these cells, leading to a compromised glomerular filtration barrier and proteinuria, indicating the loss of proteins in the urine.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1016/j.biocel.2010.05.015", xref="DOI:10.1016/j.yexcr.2012.02.032", xref="DOI:10.1111/j.1523-1755.2005.00260.x", xref="DOI:10.2337/diacare.28.1.164", xref="DOI:10.3389/fphys.2021.689083"} [Term] id: CL:1001006 name: kidney afferent arteriole cell def: "An endothelial cell which is part of the afferent arteriole in the kidney. This cell is responsible for maintaining renal blood flow and glomerular filtration rate." [PMID:16990493, PMID:22733355, PMID:24066938, PMID:25834230] subset: human_subset subset: mouse_subset xref: KUPO:0001038 is_a: CL:0002681 ! kidney cortical cell is_a: CL:1000891 {is_inferred="true"} ! kidney arterial blood vessel cell intersection_of: CL:1000891 ! kidney arterial blood vessel cell intersection_of: BFO:0000050 UBERON:0004639 ! part of renal afferent arteriole relationship: BFO:0000050 UBERON:0004639 ! part of renal afferent arteriole property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_1001006" xsd:string {name="kidney afferent arteriole cell on CELLxGENE CellGuide"} property_value: terms:description "Kidney afferent arteriole cells are specialized cell types found in the renal vasculature, specifically in the afferent arterioles which help in maintaining the renal blood flow and glomerular filtration rate. They are essential for the proper functioning of the kidneys, contributing to the regulation of blood pressure and fluid balance within the organism. Located before the glomerulus, a tiny, intricate network of capillaries within the nephron, these cells help control the expansion or contraction of the arteriole, thus regulating the pressure and flow of blood into the glomerulus.\nFunctionally, kidney afferent arteriole cells are largely involved in responding to changes in blood volume and systemic blood pressure. They achieve this by modulating the diameter of the afferent arteriole through a process known as autoregulation. Autoregulation involves two primary mechanisms: the myogenic response and the tubuloglomerular feedback. The myogenic response is essentially the intrinsic ability of the vascular smooth muscle to respond to pressure changes, while the tubuloglomerular feedback is the process where the macula densa cells located near the glomerulus respond to changes in fluid delivery rates in the tubules, sending signals to afferent arterioles to constrict or dilate accordingly. These cells also have significant interaction with renin-containing juxtaglomerular cells, which are located in the wall of afferent arterioles. Juxtaglomerular cells secrete the enzyme renin in response to low blood pressure or sympathetic nerve activity, initiating the renin-angiotensin-aldosterone system cascade that ultimately helps retain sodium and water to increase blood volume and pressure.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1007/s00424-012-1126-7", xref="DOI:10.1152/ajpregu.00332.2006", xref="DOI:10.1152/physrev.00042.2012", xref="DOI:10.2174/15701611113116660149"} [Term] id: CL:1001009 name: kidney efferent arteriole cell def: "Any kidney arterial blood vessel cell that is part of some renal efferent arteriole." [FBC:Autogenerated] subset: human_subset subset: mouse_subset xref: KUPO:0001041 is_a: CL:0002681 ! kidney cortical cell is_a: CL:1000891 ! kidney arterial blood vessel cell intersection_of: CL:1000891 ! kidney arterial blood vessel cell intersection_of: BFO:0000050 UBERON:0004640 ! part of renal efferent arteriole relationship: BFO:0000050 UBERON:0004640 ! part of renal efferent arteriole property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_1001009" xsd:string {name="kidney efferent arteriole cell on CELLxGENE CellGuide"} property_value: terms:description "Kidney efferent arteriole cells are highly adaptable vascular cells that make up the efferent arterioles in the kidney. These units are integral components of the renal microcirculation system, conducting blood away from the glomeruli after filtration occurs. Efferent arterioles directly affect glomerular hydrostatic pressure and, subsequently, the rate of glomerular filtration. They are the downstream channels that ensure the effective transportation of blood to the peritubular capillaries and vasa recta, critical for maintaining fluid balance and electrolyte homeostasis.\nKidney efferent arteriole cells are exceptional in their ability to perform autoregulation—a critical dynamic control of intrarenal blood flow ensuring stable glomerular filtration rates. This is primarily achieved via myogenic and tubuloglomerular feedback mechanisms, where the cells respond to changes in pressure and the concentration of sodium chloride in the tubular fluid, and constrict or dilate depending on the detected changes.\nCells associated with the efferent arteriole also respond to several systemic influences. Through complex intracellular signaling pathways, they respond to fluctuations in hormones (like angiotensin II and endothelin) and several other mediators such as nitric oxide and prostaglandins. Their adaptive capability helps maintain homeostasis and ensures the entire system's optimal performance under various physiological conditions. Dysfunctions in kidney efferent arteriole cells can lead to severe pathologies like hypertension and chronic kidney disease.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1152/ajpregu.2000.279.2.R629", xref="DOI:10.1152/physrev.00042.2012", xref="DOI:10.1159/000072054", xref="DOI:10.1161/01.HYP.29.1.222", xref="DOI:10.3748/wjg.v12.i34.5429"} [Term] id: CL:1001016 name: kidney loop of Henle ascending limb epithelial cell def: "Any kidney loop of Henle epithelial cell that is part of some ascending limb of loop of Henle." [FBC:Autogenerated] subset: cellxgene_subset subset: human_subset subset: kidney_upper_slim subset: mouse_subset xref: KUPO:0001048 is_a: CL:0002305 ! epithelial cell of distal tubule is_a: CL:1000909 {is_inferred="true"} ! kidney loop of Henle epithelial cell intersection_of: CL:1000909 ! kidney loop of Henle epithelial cell intersection_of: BFO:0000050 UBERON:0005164 ! part of ascending limb of loop of Henle relationship: BFO:0000050 UBERON:0005164 ! part of ascending limb of loop of Henle [Term] id: CL:1001021 name: kidney loop of Henle descending limb epithelial cell def: "Any kidney loop of Henle epithelial cell that is part of some descending limb of loop of Henle." [FBC:Autogenerated] subset: cellxgene_subset subset: human_subset subset: kidney_upper_slim subset: mouse_subset xref: KUPO:0001053 is_a: CL:1000909 {is_inferred="true"} ! kidney loop of Henle epithelial cell intersection_of: CL:1000909 ! kidney loop of Henle epithelial cell intersection_of: BFO:0000050 UBERON:0001289 ! part of descending limb of loop of Henle relationship: BFO:0000050 UBERON:0001289 ! part of descending limb of loop of Henle property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_1001021" xsd:string {name="kidney loop of Henle descending limb epithelial cell on CELLxGENE CellGuide"} property_value: terms:description "The kidney loop of Henle descending limb epithelial cells are highly specialized cells that play a crucial role in maintaining the body's salt and water balance. These cells line the descending limb of the loop of Henle, which is a portion of the renal tubule located in the kidneys, an organ responsible for filtering waste products, ions and extra water from the blood and converting them into urine. However, the descending limb epithelial cells are specifically involved in the countercurrent multiplication system, a mechanism to concentrate urine that involves both active and passive transport processes. \nThese cells are notably permeable to water but relatively impermeable to solutes, a characteristic that dramatically influences the osmotic gradient in the renal medulla. As filtrate initially descends down the loop of Henle, water gets drawn out due to the increasing osmotic gradient, thereby concentrating the filtrate. Additionally, these epithelial cells are exceptionally thin walled, allowing water to freely diffuse across the membrane.\nFurthermore, the kidney loop of Henle descending limb epithelial cells are inextricably linked to the functioning of numerous diuretic drugs, which work by blocking the reabsorption of water and certain electrolytes in the kidneys, leading to increased urine production to rid the body of excess fluids.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1007/s00360-018-1164-3", xref="DOI:10.1146/annurev-physiol-021113-170350", xref="DOI:10.1152/advan.00227.2022"} [Term] id: CL:1001033 name: peritubular capillary endothelial cell def: "An endothelial cell that is part of the peritubular capillary of the kidney. This cell is highly fenestrated and plays a vital role in the kidney's filtration process, enabling the exchange of materials between the blood and the renal tubules." [PMID:19129259] comment: Peritubular capillary endothelial cells feature fenestrations measuring 60-70 nm in diameter, each traversed by a thin diaphragm. {xref="PMID:19129259"} subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset xref: KUPO:0001065 is_a: CL:0000666 ! fenestrated endothelial cell is_a: CL:1000892 ! kidney capillary endothelial cell intersection_of: CL:1000892 ! kidney capillary endothelial cell intersection_of: BFO:0000050 UBERON:0012441 ! part of endothelium of peritubular capillary relationship: BFO:0000050 UBERON:0012441 ! part of endothelium of peritubular capillary property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:1001036 name: vasa recta cell def: "A cell that is part of a vasa recta." [PMID:12529271, PMID:24381184] subset: cellxgene_subset subset: human_subset subset: mouse_subset xref: KUPO:0001068 is_a: CL:1000504 {is_inferred="true"} ! kidney medulla cell is_a: CL:2000008 ! microvascular endothelial cell intersection_of: CL:2000008 ! microvascular endothelial cell intersection_of: BFO:0000050 UBERON:0004726 ! part of vasa recta relationship: BFO:0000050 UBERON:0004726 ! part of vasa recta [Term] id: CL:1001045 name: kidney cortex artery cell def: "Any kidney arterial blood vessel cell that is part of some renal cortex artery." [FBC:Autogenerated] subset: cellxgene_subset subset: human_subset subset: mouse_subset xref: KUPO:0001077 is_a: CL:0002681 ! kidney cortical cell is_a: CL:1000891 ! kidney arterial blood vessel cell intersection_of: CL:1000891 ! kidney arterial blood vessel cell intersection_of: BFO:0000050 UBERON:0005268 ! part of renal cortex artery relationship: BFO:0000050 UBERON:0005268 ! part of renal cortex artery [Term] id: CL:1001052 name: kidney cortex vein cell def: "Any kidney venous blood vessel cell that is part of some renal cortex vein." [FBC:Autogenerated] subset: human_subset subset: mouse_subset xref: KUPO:0001084 is_a: CL:0002681 ! kidney cortical cell is_a: CL:1000893 {is_inferred="true"} ! kidney venous blood vessel cell intersection_of: CL:1000893 ! kidney venous blood vessel cell intersection_of: BFO:0000050 UBERON:0005269 ! part of renal cortex vein relationship: BFO:0000050 UBERON:0005269 ! part of renal cortex vein [Term] id: CL:1001064 name: kidney artery smooth muscle cell comment: Note that the source of this term is KUPO:0001096 (artery smooth muscle cell), which we believe actually denotes the kidney specific structure. subset: human_subset subset: mouse_subset xref: KUPO:0001096 is_a: CL:0019018 ! blood vessel smooth muscle cell is_a: CL:1000891 ! kidney arterial blood vessel cell [Term] id: CL:1001066 name: kidney arteriole smooth muscle cell comment: Note that the source of this term is KUPO:0001098 (arteriole smooth muscle cell), which we believe actually denotes the kidney specific structure. subset: human_subset subset: mouse_subset xref: KUPO:0001098 is_a: CL:0019018 ! blood vessel smooth muscle cell is_a: CL:1000891 ! kidney arterial blood vessel cell [Term] id: CL:1001068 name: kidney venous system smooth muscle cell comment: Note that the source of this term is KUPO:0001068 (venous system smooth muscle cell), which we believe actually denotes the kidney specific structure. subset: human_subset subset: mouse_subset xref: KUPO:0001100 is_a: CL:0019018 ! blood vessel smooth muscle cell is_a: CL:1000893 ! kidney venous blood vessel cell [Term] id: CL:1001096 name: kidney afferent arteriole endothelial cell def: "An endothelial cell that lines the interior surface of the afferent arteriole and maintains vascular tone. This cell responds to changing ion concentrations and blood pressure by releasing vasoactive substances, in order to regulate blood flow into the glomeruli, which is essential for glomerular filtration." [PMID:16990493, PMID:22733355, PMID:24066938, PMID:25834230] subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset xref: KUPO:0001039 is_a: CL:1000412 ! endothelial cell of arteriole is_a: CL:1001006 ! kidney afferent arteriole cell intersection_of: CL:0000115 ! endothelial cell intersection_of: BFO:0000050 UBERON:0004639 ! part of renal afferent arteriole property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/2d-ftu/kidney-renal-corpuscle/v1.2/assets/2d-ftu-kidney-renal-corpuscle.png" xsd:string {terms:licence="http://creativecommons.org/licenses/by/4.0/", xref="doi:10.48539/HBM778.SHGJ.294"} property_value: RO:0002175 NCBITaxon:9606 property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_1001096" xsd:string {name="kidney afferent arteriole endothelial cell on CELLxGENE CellGuide"} property_value: terms:description "Kidney afferent arteriole endothelial cells are a specialized type of cell located within the kidneys, forming the inner lining of the afferent arterioles, which are responsible for delivering blood to the glomeruli - capillary networks responsible for filtration - from where the process of urine formation begins in the nephrons.\nThe endothelial cells in the kidney afferent arterioles have a key function in regulating the blood flow and filtration. They have autocrine and paracrine signaling capabilities, meaning they can signal to themselves and other nearby cells. They produce nitric oxide, prostacyclin, and endothelin, which are powerful vasodilators and vasoconstrictors that regulate renal blood flow. These cells also engage in the mitigation of kidney injury and inflammation by promoting repair and regeneration, demonstrating the multifaceted roles these cells play in maintaining renal health.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1046/j.0001-6772.2003.01205.x", xref="DOI:10.1093/ndt/gfl308"} [Term] id: CL:1001097 name: kidney afferent arteriole smooth muscle cell def: "A smooth muscle cell found in the wall of the afferent arteriole. This cell contracts and relaxes in response to changes in blood pressure, a process known as a myogenic response, to alter artery diameter and regulate blood flow into the glomeruli." [PMID:16990493, PMID:22733355, PMID:24066938, PMID:25834230] subset: human_subset subset: mouse_subset xref: KUPO:0001040 is_a: CL:0008035 ! microcirculation associated smooth muscle cell is_a: CL:1001006 ! kidney afferent arteriole cell is_a: CL:1001066 ! kidney arteriole smooth muscle cell intersection_of: CL:0000192 ! smooth muscle cell intersection_of: BFO:0000050 UBERON:0004639 ! part of renal afferent arteriole [Term] id: CL:1001099 name: kidney efferent arteriole endothelial cell def: "Any endothelial cell that is part of some renal efferent arteriole." [FBC:Autogenerated] subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset xref: KUPO:0001042 is_a: CL:1000412 ! endothelial cell of arteriole is_a: CL:1001009 ! kidney efferent arteriole cell intersection_of: CL:0000115 ! endothelial cell intersection_of: BFO:0000050 UBERON:0004640 ! part of renal efferent arteriole property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/2d-ftu/kidney-renal-corpuscle/v1.2/assets/2d-ftu-kidney-renal-corpuscle.png" xsd:string {terms:licence="http://creativecommons.org/licenses/by/4.0/", xref="doi:10.48539/HBM778.SHGJ.294"} property_value: RO:0002175 NCBITaxon:9606 property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_1001099" xsd:string {name="kidney efferent arteriole endothelial cell on CELLxGENE CellGuide"} property_value: terms:description "Kidney efferent arteriole endothelial cells constitute a vital component of the kidney's microvascular system. They are unique endothelial cells found lining the walls of efferent arterioles, which transport blood away from the glomeruli in the kidney.\nThe primary responsibilities of the kidney efferent arteriole endothelial cells involve controling renal blood flow, regulating glomerular filtration rate (GFR), and managing perfusion pressure. They do this by contracting and relaxing, effectively narrowing and widening the arteriole's lumen thereby controling the volume and rate of blood flow to the peritubular capillaries and creating the pressure gradient necessary for filtration in the glomerulus. \nFurthermore, kidney efferent arteriole endothelial cells show a high degree of plasticity in response to pathophysiological stimuli and can undergo structural and functional changes based on local needs. In conditions like hypertension and diabetes, these cells can experience hypertrophy and endothelial dysfunction, contributing to the progression of renal disease.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1016/j.semcdb.2014.08.002", xref="DOI:10.1016/j.semnephrol.2015.01.010", xref="DOI:10.1038/s41581-021-00411-9", xref="DOI:10.1681/ASN.2019111179"} [Term] id: CL:1001100 name: kidney efferent arteriole smooth muscle cell def: "Any smooth muscle cell that is part of some renal efferent arteriole." [FBC:Autogenerated] subset: human_subset subset: mouse_subset xref: KUPO:0001043 is_a: CL:0008035 ! microcirculation associated smooth muscle cell is_a: CL:1001009 ! kidney efferent arteriole cell is_a: CL:1001066 ! kidney arteriole smooth muscle cell intersection_of: CL:0000192 ! smooth muscle cell intersection_of: BFO:0000050 UBERON:0004640 ! part of renal efferent arteriole [Term] id: CL:1001106 name: kidney loop of Henle thick ascending limb epithelial cell def: "An epithelial cell that is part of some loop of Henle thick ascending limb. It is known in some mammalian species that this cell may express the Na+-K+-2Cl− cotransporter (NKCC2) apically." [PMID:25318757] subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset xref: KUPO:0001049 is_a: CL:1000504 ! kidney medulla cell is_a: CL:1001016 {is_inferred="true"} ! kidney loop of Henle ascending limb epithelial cell intersection_of: CL:1001016 ! kidney loop of Henle ascending limb epithelial cell intersection_of: BFO:0000050 UBERON:0001291 ! part of thick ascending limb of loop of Henle relationship: BFO:0000050 UBERON:0001291 ! part of thick ascending limb of loop of Henle property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/2d-ftu/kidney-nephron/v1.2/assets/2d-ftu-kidney-nephron.png" xsd:string {terms:licence="http://creativecommons.org/licenses/by/4.0/", xref="doi:10.48539/HBM927.DQNW.448"} property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/2d-ftu/kidney-thick-ascending-loop-of-henle/v1.2/assets/2d-ftu-kidney-thick-ascending-loop-of-henle.png" xsd:string {terms:licence="http://creativecommons.org/licenses/by/4.0/", xref="doi:10.48539/HBM299.GSQS.249"} property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:1001107 name: kidney loop of Henle thin ascending limb epithelial cell def: "An epithelial cell that is part of some loop of Henle thin ascending limb." [] subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset xref: KUPO:0001050 is_a: CL:1000617 ! kidney inner medulla cell is_a: CL:1001016 {is_inferred="true"} ! kidney loop of Henle ascending limb epithelial cell intersection_of: CL:1001016 ! kidney loop of Henle ascending limb epithelial cell intersection_of: BFO:0000050 UBERON:0004193 ! part of loop of Henle ascending limb thin segment relationship: BFO:0000050 UBERON:0004193 ! part of loop of Henle ascending limb thin segment property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/2d-ftu/kidney-ascending-thin-loop-of-henle/v1.2/assets/2d-ftu-kidney-ascending-thin-loop-of-henle.png" xsd:string {terms:licence="http://creativecommons.org/licenses/by/4.0/", xref="doi:10.48539/HBM489.KLNJ.323"} property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/2d-ftu/kidney-nephron/v1.2/assets/2d-ftu-kidney-nephron.png" xsd:string {terms:licence="http://creativecommons.org/licenses/by/4.0/", xref="doi:10.48539/HBM927.DQNW.448"} property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:1001108 name: kidney loop of Henle medullary thick ascending limb epithelial cell def: "An epithelial cell that is part of some loop of Henle thick ascending limb segment located in the renal medulla." [] subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset xref: KUPO:0001051 is_a: CL:1000616 {is_inferred="true"} ! kidney outer medulla cell is_a: CL:1001106 ! kidney loop of Henle thick ascending limb epithelial cell intersection_of: CL:1001016 ! kidney loop of Henle ascending limb epithelial cell intersection_of: BFO:0000050 UBERON:0006376 ! part of premacula segment of distal straight tubule relationship: BFO:0000050 UBERON:0006376 ! part of premacula segment of distal straight tubule property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:1001109 name: kidney loop of Henle cortical thick ascending limb epithelial cell def: "An epithelial cell that is part of some loop of Henle thick ascending limb segment located in the renal cortex." [] subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset xref: KUPO:0001052 is_a: CL:1001106 ! kidney loop of Henle thick ascending limb epithelial cell intersection_of: CL:1001016 ! kidney loop of Henle ascending limb epithelial cell intersection_of: BFO:0000050 UBERON:0006854 ! part of distal straight tubule postmacula segment relationship: BFO:0000050 UBERON:0006854 ! part of distal straight tubule postmacula segment property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:1001111 name: kidney loop of Henle thin descending limb epithelial cell def: "An epithelial cell that is part of some loop of Henle thin descending limb." [] subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset xref: KUPO:0001054 is_a: CL:1000453 ! epithelial cell of intermediate tubule is_a: CL:1000616 ! kidney outer medulla cell is_a: CL:1001021 {is_inferred="true"} ! kidney loop of Henle descending limb epithelial cell intersection_of: CL:1001021 ! kidney loop of Henle descending limb epithelial cell intersection_of: BFO:0000050 UBERON:0005096 ! part of descending thin limb relationship: BFO:0000050 UBERON:0005096 ! part of descending thin limb property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/2d-ftu/kidney-descending-thin-loop-of-henle/v1.1/assets/2d-ftu-kidney-descending-thin-loop-of-henle.png" xsd:string {terms:licence="http://creativecommons.org/licenses/by/4.0/", xref="doi:10.48539/HBM979.XZTC.458"} property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/2d-ftu/kidney-nephron/v1.2/assets/2d-ftu-kidney-nephron.png" xsd:string {terms:licence="http://creativecommons.org/licenses/by/4.0/", xref="doi:10.48539/HBM927.DQNW.448"} property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:1001123 name: kidney outer medulla peritubular capillary cell def: "An endothelial cell that is part of the peritubular capillary of the outer renal medulla." [] subset: human_subset subset: mouse_subset xref: KUPO:0001066 is_a: CL:1000616 ! kidney outer medulla cell is_a: CL:1001033 ! peritubular capillary endothelial cell intersection_of: CL:1001033 ! peritubular capillary endothelial cell intersection_of: BFO:0000050 UBERON:0006341 ! part of outer renal medulla peritubular capillary relationship: BFO:0000050 UBERON:0006341 ! part of outer renal medulla peritubular capillary [Term] id: CL:1001124 name: kidney cortex peritubular capillary cell def: "An endothelial cell that is part of the peritubular capillary of the renal cortex." [] subset: human_subset subset: mouse_subset xref: KUPO:0001067 is_a: CL:0002681 ! kidney cortical cell is_a: CL:1001033 ! peritubular capillary endothelial cell intersection_of: CL:1001033 ! peritubular capillary endothelial cell intersection_of: BFO:0000050 UBERON:0006851 ! part of renal cortex peritubular capillary relationship: BFO:0000050 UBERON:0006851 ! part of renal cortex peritubular capillary [Term] id: CL:1001126 name: inner renal medulla vasa recta cell def: "Any vasa recta cell that is part of some inner renal medulla vasa recta." [FBC:Autogenerated] subset: human_subset subset: mouse_subset xref: KUPO:0001069 is_a: CL:1000617 {is_inferred="true"} ! kidney inner medulla cell is_a: CL:1001036 {is_inferred="true"} ! vasa recta cell intersection_of: CL:1001036 ! vasa recta cell intersection_of: BFO:0000050 UBERON:0004776 ! part of inner renal medulla vasa recta relationship: BFO:0000050 UBERON:0004776 ! part of inner renal medulla vasa recta [Term] id: CL:1001127 name: outer renal medulla vasa recta cell def: "Any vasa recta cell that is part of some outer renal medulla vasa recta." [FBC:Autogenerated] subset: human_subset subset: mouse_subset xref: KUPO:0001070 is_a: CL:1000616 {is_inferred="true"} ! kidney outer medulla cell is_a: CL:1001036 {is_inferred="true"} ! vasa recta cell intersection_of: CL:1001036 ! vasa recta cell intersection_of: BFO:0000050 UBERON:0004775 ! part of outer renal medulla vasa recta relationship: BFO:0000050 UBERON:0004775 ! part of outer renal medulla vasa recta [Term] id: CL:1001131 name: vasa recta ascending limb cell def: "A cell that is part of some vasa recta ascending limb." [] comment: It is known in some mammalian species that this cell may express PV-1, a component of the fenestral diaphragm. {xref="PMID:20392799", xref="PMID:20392798", xref="PMID:26062876"} subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset xref: KUPO:0001074 is_a: CL:1001036 {is_inferred="true"} ! vasa recta cell intersection_of: CL:1001036 ! vasa recta cell intersection_of: BFO:0000050 UBERON:0009091 ! part of ascending vasa recta relationship: BFO:0000050 UBERON:0009091 ! part of ascending vasa recta property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/2d-ftu/kidney-ascending-thin-loop-of-henle/v1.2/assets/2d-ftu-kidney-ascending-thin-loop-of-henle.png" xsd:string {terms:licence="http://creativecommons.org/licenses/by/4.0/", xref="doi:10.48539/HBM489.KLNJ.323"} property_value: RO:0002175 NCBITaxon:9606 property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_1001131" xsd:string {name="vasa recta ascending limb cell on CELLxGENE CellGuide"} property_value: terms:description "The vasa recta ascending limb cells are specialized epithelial cells that are part of the vasa recta in the kidney, a crucial component of the renal medulla that functions as a counter-current exchanger to maintain the concentration gradient required for water reabsorption. These particular cells are located in the ascending limb of the vasa recta, which takes blood flow from the medulla back to the cortex. \nThe primary function of vasa recta ascending limb cells is to preserve the renal medulla's hypertonicity, necessary for the kidney's urine concentration mechanism. Unlike the vasa recta descending limb cells, the venous-like epithelial cells of the ascending vasa recta are highly fenestrated and lack pericyte coverage, which facilitates water reuptake. \nAs the blood flows through the ascending limb, it loses solutes and gains water, which is driven by the high solute concentration in the surrounding interstitium. This process acts in concert with cellular action in the descending limb and contributions from the so-called Loop of Henle, which helps with water and sodium chloride retrieval from the urine.\nIn the context of normal physiological processes, the function of the vasa recta ascending limb cells is essential in maintaining the body's overall fluid balance, electrolyte concentration, and systemic blood pressure. Any dysfunction in these cells may lead to impaired urine concentration or dilution capability of the kidney, potentially resulting in conditions like diabetes insipidus or hyponatremia.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1016/B978-0-323-35515-5.00009-9", xref="DOI:10.1053/j.ajkd.2005.01.008", xref="DOI:10.1081/jdi-100101958", xref="DOI:10.1111/apha.12026", xref="DOI:10.1152/ajpregu.00657.2002"} [Term] id: CL:1001135 name: arcuate artery cell def: "Any kidney cortex artery cell that is part of some kidney arcuate artery." [FBC:Autogenerated] subset: human_subset subset: mouse_subset xref: KUPO:0001078 is_a: CL:1001045 {is_inferred="true"} ! kidney cortex artery cell intersection_of: CL:1001045 ! kidney cortex artery cell intersection_of: BFO:0000050 UBERON:0001552 ! part of kidney arcuate artery relationship: BFO:0000050 UBERON:0001552 ! part of kidney arcuate artery [Term] id: CL:1001138 name: interlobular artery cell def: "Any kidney cortex artery cell that is part of some interlobular artery." [FBC:Autogenerated] subset: human_subset subset: mouse_subset xref: KUPO:0001081 is_a: CL:1001045 {is_inferred="true"} ! kidney cortex artery cell intersection_of: CL:1001045 ! kidney cortex artery cell intersection_of: BFO:0000050 UBERON:0004723 ! part of interlobular artery relationship: BFO:0000050 UBERON:0004723 ! part of interlobular artery [Term] id: CL:1001142 name: arcuate vein cell def: "Any kidney cortex vein cell that is part of some kidney arcuate vein." [FBC:Autogenerated] subset: human_subset subset: mouse_subset xref: KUPO:0001085 is_a: CL:1001052 {is_inferred="true"} ! kidney cortex vein cell intersection_of: CL:1001052 ! kidney cortex vein cell intersection_of: BFO:0000050 UBERON:0004719 ! part of kidney arcuate vein relationship: BFO:0000050 UBERON:0004719 ! part of kidney arcuate vein [Term] id: CL:1001145 name: interlobular vein cell def: "Any kidney cortex vein cell that is part of some renal interlobular vein." [FBC:Autogenerated] subset: human_subset subset: mouse_subset xref: KUPO:0001088 is_a: CL:1001052 {is_inferred="true"} ! kidney cortex vein cell intersection_of: CL:1001052 ! kidney cortex vein cell intersection_of: BFO:0000050 UBERON:0005168 ! part of renal interlobular vein relationship: BFO:0000050 UBERON:0005168 ! part of renal interlobular vein [Term] id: CL:1001209 name: inner medulla vasa recta ascending limb cell def: "Any vasa recta ascending limb cell that is part of some inner medulla ascending vasa recta." [FBC:Autogenerated] subset: human_subset subset: mouse_subset xref: KUPO:0001075 is_a: CL:1001126 {is_inferred="true"} ! inner renal medulla vasa recta cell is_a: CL:1001131 {is_inferred="true"} ! vasa recta ascending limb cell intersection_of: CL:1001131 ! vasa recta ascending limb cell intersection_of: BFO:0000050 UBERON:0009092 ! part of inner medulla ascending vasa recta relationship: BFO:0000050 UBERON:0009092 ! part of inner medulla ascending vasa recta [Term] id: CL:1001210 name: outer medulla vasa recta ascending limb cell def: "Any vasa recta ascending limb cell that is part of some outer medulla ascending vasa recta." [FBC:Autogenerated] subset: human_subset subset: mouse_subset xref: KUPO:0001076 is_a: CL:1001127 {is_inferred="true"} ! outer renal medulla vasa recta cell is_a: CL:1001131 {is_inferred="true"} ! vasa recta ascending limb cell intersection_of: CL:1001131 ! vasa recta ascending limb cell intersection_of: BFO:0000050 UBERON:0009093 ! part of outer medulla ascending vasa recta relationship: BFO:0000050 UBERON:0009093 ! part of outer medulla ascending vasa recta [Term] id: CL:1001213 name: arcuate artery endothelial cell def: "Any endothelial cell that is part of some kidney arcuate artery." [FBC:Autogenerated] subset: human_subset subset: mouse_subset xref: KUPO:0001079 is_a: CL:1000413 ! endothelial cell of artery is_a: CL:1001135 ! arcuate artery cell intersection_of: CL:0000115 ! endothelial cell intersection_of: BFO:0000050 UBERON:0001552 ! part of kidney arcuate artery [Term] id: CL:1001214 name: arcuate artery smooth muscle cell def: "Any smooth muscle cell that is part of some kidney arcuate artery." [FBC:Autogenerated] subset: human_subset subset: mouse_subset xref: KUPO:0001080 is_a: CL:1001064 ! kidney artery smooth muscle cell is_a: CL:1001135 ! arcuate artery cell intersection_of: CL:0000192 ! smooth muscle cell intersection_of: BFO:0000050 UBERON:0001552 ! part of kidney arcuate artery [Term] id: CL:1001216 name: interlobulary artery endothelial cell def: "Any endothelial cell that is part of some interlobular artery." [FBC:Autogenerated] subset: human_subset subset: mouse_subset xref: KUPO:0001082 is_a: CL:1000413 ! endothelial cell of artery is_a: CL:1001138 ! interlobular artery cell intersection_of: CL:0000115 ! endothelial cell intersection_of: BFO:0000050 UBERON:0004723 ! part of interlobular artery [Term] id: CL:1001217 name: interlobulary artery smooth muscle cell def: "Any smooth muscle cell that is part of some interlobular artery." [FBC:Autogenerated] subset: human_subset subset: mouse_subset xref: KUPO:0001083 is_a: CL:1001064 ! kidney artery smooth muscle cell is_a: CL:1001138 ! interlobular artery cell intersection_of: CL:0000192 ! smooth muscle cell intersection_of: BFO:0000050 UBERON:0004723 ! part of interlobular artery [Term] id: CL:1001220 name: arcuate vein endothelial cell def: "Any endothelial cell that is part of some kidney arcuate vein." [FBC:Autogenerated] subset: human_subset subset: mouse_subset xref: KUPO:0001086 is_a: CL:0002543 ! vein endothelial cell is_a: CL:1001142 ! arcuate vein cell intersection_of: CL:0000115 ! endothelial cell intersection_of: BFO:0000050 UBERON:0004719 ! part of kidney arcuate vein [Term] id: CL:1001221 name: arcuate vein smooth muscle cell def: "Any smooth muscle cell that is part of some kidney arcuate vein." [FBC:Autogenerated] subset: human_subset subset: mouse_subset xref: KUPO:0001087 is_a: CL:1001068 ! kidney venous system smooth muscle cell is_a: CL:1001142 ! arcuate vein cell intersection_of: CL:0000192 ! smooth muscle cell intersection_of: BFO:0000050 UBERON:0004719 ! part of kidney arcuate vein [Term] id: CL:1001223 name: interlobulary vein endothelial cell def: "Any endothelial cell that is part of some renal interlobular vein." [FBC:Autogenerated] subset: human_subset subset: mouse_subset xref: KUPO:0001089 is_a: CL:0002543 ! vein endothelial cell is_a: CL:1001145 ! interlobular vein cell intersection_of: CL:0000115 ! endothelial cell intersection_of: BFO:0000050 UBERON:0005168 ! part of renal interlobular vein [Term] id: CL:1001224 name: interlobulary vein smooth muscle cell def: "Any smooth muscle cell that is part of some renal interlobular vein." [FBC:Autogenerated] subset: human_subset subset: mouse_subset xref: KUPO:0001090 is_a: CL:1001068 ! kidney venous system smooth muscle cell is_a: CL:1001145 ! interlobular vein cell intersection_of: CL:0000192 ! smooth muscle cell intersection_of: BFO:0000050 UBERON:0005168 ! part of renal interlobular vein [Term] id: CL:1001225 name: kidney collecting duct cell def: "A cell that is part of a collecting duct of renal tubule." [] subset: cellxgene_subset subset: human_subset subset: mouse_subset xref: KUPO:0001012 xref: Wikipedia:Kidney_collecting_duct_cell is_a: CL:1000497 ! kidney cell intersection_of: CL:1000497 ! kidney cell intersection_of: BFO:0000050 UBERON:0001232 ! part of collecting duct of renal tubule relationship: BFO:0000050 UBERON:0001232 ! part of collecting duct of renal tubule [Term] id: CL:1001285 name: vasa recta descending limb cell def: "A cell that is part of some vasa recta descending limb." [] comment: It is known in some mammalian species that this cell may express the urea transporter B. {xref="PMID:20392799", xref="PMID:20392798", xref="PMID:26062876"} subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset xref: KUPO:0001071 is_a: CL:1001036 {is_inferred="true"} ! vasa recta cell intersection_of: CL:1001036 ! vasa recta cell intersection_of: BFO:0000050 UBERON:0009202 ! part of descending vasa recta relationship: BFO:0000050 UBERON:0009202 ! part of descending vasa recta property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/2d-ftu/kidney-descending-thin-loop-of-henle/v1.1/assets/2d-ftu-kidney-descending-thin-loop-of-henle.png" xsd:string {terms:licence="http://creativecommons.org/licenses/by/4.0/", xref="doi:10.48539/HBM979.XZTC.458"} property_value: RO:0002175 NCBITaxon:9606 property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_1001285" xsd:string {name="vasa recta descending limb cell on CELLxGENE CellGuide"} property_value: terms:description "Vasa recta descending limb cells are specialized epithelial cells found in the vasa recta, a network of blood vessels in the renal medulla. These cells line the interior surface of the descending limb of the vasa recta and play a crucial role in the filtering and regulation of substances within the blood.\nIn contrast to vasa recta ascending limb cells, the arterial-like epithelial cells of the descending vasa recta are non-fenestrated and covered by a pericyte layer that regulates the medullary blood flow. They help keeping the body’s fluid and electrolyte balance in check through a process known as countercurrent exchange system, in which the cells of the descending limb are permeable to water but relatively impermeable to solutes, such as sodium and urea. As the blood descends into the medulla along its descending limb, water passively diffuses out of the vasa recta, concentrating the blood in solutes.\nIn addition to their central role in water and solute exchange, these cells contribute to maintaining the medullary osmotic gradient, a critical function to concentrate urine. The osmotic gradient is created by the counterflow of water and solutes between the descending and ascending limbs of the vasa recta and the adjacent Loop of Henle. The selective permeability of the descending limb cells allows them to maintain this gradient, which in turn helps to conserve water, a vital role in the overall function of the renal system. Thus, vasa recta descending limb cells have a significant function in renal physiology, particularly in osmoregulation and fluid balance.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1053/j.ajkd.2005.01.008", xref="DOI:10.1081/jdi-100101958", xref="DOI:10.1111/apha.12026#apha12026-bib-0039", xref="DOI:10.1152/ajpregu.00657.2002"} [Term] id: CL:1001286 name: inner medulla vasa recta descending limb cell def: "Any vasa recta descending limb cell that is part of some inner medulla descending vasa recta." [FBC:Autogenerated] subset: human_subset subset: mouse_subset xref: KUPO:0001072 is_a: CL:1001126 {is_inferred="true"} ! inner renal medulla vasa recta cell is_a: CL:1001285 {is_inferred="true"} ! vasa recta descending limb cell intersection_of: CL:1001285 ! vasa recta descending limb cell intersection_of: BFO:0000050 UBERON:0009089 ! part of inner medulla descending vasa recta relationship: BFO:0000050 UBERON:0009089 ! part of inner medulla descending vasa recta [Term] id: CL:1001287 name: outer medulla vasa recta descending limb cell def: "Any vasa recta descending limb cell that is part of some outer medulla descending vasa recta." [FBC:Autogenerated] subset: human_subset subset: mouse_subset xref: KUPO:0001073 is_a: CL:1001127 {is_inferred="true"} ! outer renal medulla vasa recta cell is_a: CL:1001285 {is_inferred="true"} ! vasa recta descending limb cell intersection_of: CL:1001285 ! vasa recta descending limb cell intersection_of: BFO:0000050 UBERON:0009090 ! part of outer medulla descending vasa recta relationship: BFO:0000050 UBERON:0009090 ! part of outer medulla descending vasa recta [Term] id: CL:1001318 name: renal interstitial pericyte def: "A pericyte cell located in the kidney interstitium." [] subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset xref: KUPO:0001104 is_a: CL:0000669 {is_inferred="true"} ! pericyte is_a: CL:1000500 ! kidney interstitial cell intersection_of: CL:0000669 ! pericyte intersection_of: BFO:0000050 UBERON:0005215 ! part of kidney interstitium property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:1001319 name: bladder cell def: "Any cell that is part of some urinary bladder." [FBC:Autogenerated] subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset xref: KUPO:0001120 is_a: CL:1000600 ! lower urinary tract cell intersection_of: CL:0000000 ! cell intersection_of: BFO:0000050 UBERON:0001255 ! part of urinary bladder relationship: BFO:0000050 UBERON:0001255 ! part of urinary bladder property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:1001320 name: urethra cell def: "Any cell that is part of some urethra." [FBC:Autogenerated] subset: human_subset subset: mouse_subset xref: KUPO:0001123 is_a: CL:1000600 ! lower urinary tract cell intersection_of: CL:0000000 ! cell intersection_of: BFO:0000050 UBERON:0000057 ! part of urethra relationship: BFO:0000050 UBERON:0000057 ! part of urethra [Term] id: CL:1001428 name: bladder urothelial cell def: "A urothelial cell that is part of the urothelium of the urinary bladder." [doi:10.1038/s41385-022-00565-0] subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "bladder transitional cell" NARROW [] synonym: "transitional epithelial cell of urinary bladder" NARROW [] xref: KUPO:0001121 xref: NCIT:C32210 is_a: CL:0000731 ! urothelial cell is_a: CL:1001319 ! bladder cell intersection_of: CL:0000731 ! urothelial cell intersection_of: BFO:0000050 UBERON:0004645 ! part of urinary bladder urothelium relationship: BFO:0000050 UBERON:0004645 ! part of urinary bladder urothelium property_value: RO:0002175 NCBITaxon:9606 property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_1001428" xsd:string {name="bladder urothelial cell on CELLxGENE CellGuide"} property_value: terms:description "Bladder urothelial cells form the urothelium in the bladder - a specific type of epithelial tissue that constitutes the inner lining of the bladder and other parts of the urinary tract including the renal pelvis, ureters and urethra. These unique cells are specialized to withstand the highly variable and sometimes harsh conditions present in the urinary system. Their key function is maintaining the barrier integrity of the urinary tract even when exposed to high volumes of urine and its solutes, and they play a crucial role in protecting underlying tissues from damage and infection.\nThe bladder urothelial cells exhibit a remarkable spectrum of phenotypic versatility and have an extraordinary capacity to stretch and retract based on the degree of bladder filling and emptying. In their relaxed state, these cells appear large and cuboidal, but upon stretching, they become thinner and exhibit a squamous cell-like appearance. This distinctive feature enables them to adjust to the changes in the urinary bladder volume while remaining impermeable to urinary solutes, thereby preventing a potential toxicity to the bladder wall and infiltration into the bloodstream.\nApart from their barrier function, bladder urothelial cells also express a number of sensor molecules or respond to thermal, mechanical and chemical stimuli and can release signaling molecules, thereby playing a key role in sensory mechanisms that communicate vital information about the bladder's mechanical state to the nervous system. This communication helps regulate the micturition cycle and maintain urinary continence. Recent studies have also indicated that these cells may play a role in immune responses, highlighting their importance in bladder physiology. \nAltered proliferation and differentiation of bladder urothelial cells are implicated in various diseases and conditions such as bladder cancer, interstitial cystitis, and urinary tract infections.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1038/nrurol.2011.144", xref="DOI:10.1038/nrurol.2016.13", xref="DOI:10.1038/s41579-020-0324-0", xref="DOI:10.1038/s41585-020-0350-8", xref="DOI:10.1080/03008880410015165"} [Term] id: CL:1001430 name: urethra urothelial cell def: "A urothelial cell that is part of the urethra urothelium. This cell plays a crucial role in maintaining the urethral barrier function, protecting against toxic substances in urine, sensing environmental changes, and defending against pathogen entry." [PMID:23589830, PMID:36180582] subset: cellxgene_subset subset: human_subset subset: mouse_subset xref: KUPO:0001124 is_a: CL:0000731 ! urothelial cell is_a: CL:1000296 ! epithelial cell of urethra intersection_of: CL:0000731 ! urothelial cell intersection_of: BFO:0000050 UBERON:0004787 ! part of urethra urothelium relationship: BFO:0000050 UBERON:0004787 ! part of urethra urothelium property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_1001430" xsd:string {name="urethra urothelial cell on CELLxGENE CellGuide"} property_value: terms:description "Urethra urothelial cells are highly specialized epithelial cells in the urethra, which is a tubelike structure that carries urine from the bladder to the external urethral orifice. Urothelial cells form the urothelium – a stratified, transitional epithelium lining the bladder, ureters, renal pelvis and urethra. These cells are highly adapted to their specific environment and maintain the crucial function of sustaining the urinary tract's core roles, primarily to transit and store urine without auto-corrosion or pathogen proliferation.\nWithin the urethra urothelial cells are primarily found in proximal two-thirds of the urethra, while the distal third is lined by stratified squamous epithelial cells. The urothelial cells are renowned for their remarkable impermeability and ability to stretch and recoil during the various stages of urine filling and emptying. They form a tight barrier that prevents reabsorption of harmful byproducts and toxic substances present in the urine, guarding the deeper tissues and bloodstream against potential damage. This is largely attributed to specialized junctions, namely zonulae occludentes or tight junctions, in the umbrella cell layer (one of three layers of the urothelium) that seal the intercellular space between adjacent cells. Together with the urothelial plaque (an apical membrane plaque comprised of uroplakin proteins covering the umbrella cells at the luminal surface), the junctional complexes form a very effective permeability barrier that regulates the passage of water and ion from urine to the underlying tissue. \nA noteworthy feature of urothelial cells is their regulatory and sensory roles involving communication with the underlying layers about the filling and emptying status of the urinary tract. The cells also manage a fine balance between proliferation and differentiation, with the basal cells providing a ready pool of cells to replace the superficial layer when damaged. Their remarkable ability for regeneration and turnover, and their response to signals for repair underpins the durability and functionality of the urothelial tract.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1038/nrurol.2016.13", xref="DOI:10.1038/s41385-022-00565-0", xref="DOI:10.1152/physrev.00030.2012", xref="DOI:10.1152/physrev.00041.2019"} [Term] id: CL:1001431 name: kidney collecting duct principal cell def: "Any renal principal cell that is part of some collecting duct of renal tubule." [FBC:Autogenerated] subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset xref: KUPO:0001128 is_a: CL:0005009 {is_inferred="true"} ! renal principal cell is_a: CL:1000454 ! kidney collecting duct epithelial cell intersection_of: CL:0005009 ! renal principal cell intersection_of: BFO:0000050 UBERON:0001232 ! part of collecting duct of renal tubule property_value: RO:0002175 NCBITaxon:9606 property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_1001431" xsd:string {name="kidney collecting duct principal cell on CELLxGENE CellGuide"} property_value: terms:description "The kidney collecting duct principal cell is a highly specialized type of cell found in the late distal convoluted tubule and collecting duct of the kidney's nephron. Principal cells are located at the final segments of the renal tubules, where they play a pivotal role in key homeostatic processes.\nOne of their fundamental functions of kidney collecting duct principal cells is the regulation of water reabsorption, which is mediated by aquaporins (water channel proteins). Antidiuretic hormones, such as vasopressin, can stimulate the redistribution of these water channels from an intracellular pools to the apical plasma membrane of the principal cell; translocation of aquaporin (specifically, AQP2) is associated with an increase of osmotic water permeability. The water reabsorption affects the concentration of the final urine; these cells are therefore directly involved in the maintenance of the body's fluid balance.\nKidney collecting duct principal cells also participate in sodium and potassium ions regulation. They reabsorb sodium ions from the tubular fluid back into the bloodstream, a process facilitated by the action of aldosterone, a hormone released by the adrenal glands. Similarly, the principal cells secrete potassium ions into the tubular fluid in response to aldosterone, contributing to the regulation of potassium levels in the body. Impaired function of cells can lead to various renal diseases and disorders, highlighting the vital role of kidney collecting duct principal cells in the body's homeostatic processes.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1007/s11906-015-0538-0", xref="DOI:10.1016/B978-0-12-386456-7.05402-2", xref="DOI:10.1016/j.biocel.2022.106261", xref="DOI:10.1073/pnas.1710964114"} [Term] id: CL:1001432 name: kidney collecting duct intercalated cell def: "Any renal intercalated cell that is part of some collecting duct of renal tubule." [FBC:Autogenerated] subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset xref: http://en.wikipedia.org/wiki/Collecting_duct_system#Intercalated_cells xref: KUPO:0001129 is_a: CL:0005010 {is_inferred="true"} ! renal intercalated cell is_a: CL:1000454 ! kidney collecting duct epithelial cell intersection_of: CL:0005010 ! renal intercalated cell intersection_of: BFO:0000050 UBERON:0001232 ! part of collecting duct of renal tubule property_value: RO:0002175 NCBITaxon:9606 property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_1001432" xsd:string {name="kidney collecting duct intercalated cell on CELLxGENE CellGuide"} property_value: terms:description "The kidney collecting duct intercalated cell, otherwise referred to simply as the intercalated cell, is a specialized epithelial cell type primarily found in the kidney's collecting duct system. It is among the main cells that line this final component of the nephron, crucial in the physiological system that maintains acid-base homeostasis. This unique cell type comes in mainly three subtypes as per the localization of their proton pumps: type A, type B, and non-A, non-B cells. Each subtype plays different roles in regulating acid-base balance and electrolyte homeostasis in the body under varying physiological conditions. \nType A intercalated cells reabsorb bicarbonate and secrete protons into urine, leading to the production of acidic urine. These cells are typically prevalent on the renal cortex and function particularly in states of metabolic acidosis or potassium depletion. On the other hand, type B intercalated cells secrete bicarbonate and reabsorb protons; thus, they are crucial in alkaline urine production and potassium conservation. These cells are essential to counter metabolic alkalosis or situations of potassium surplus. The non-A, non-B cells have the characteristic features of both type A and B cells, but play a prominent role under conditions of chronically elevated aldosterone and angiotensin II levels. \nThrough their differentiated roles, intercalated cells also facilitate the reabsorption of sodium and chloride ions, and water to maintain osmolarity. These cells' activity is finely regulated by hormonal signals like aldosterone, angiotensin II, vasopressin, and the parathyroid hormone. Intercalated cell activity can undergo a significant transformation under pathological conditions, and their dysregulation is associated with diseases such as distal renal tubular acidosis, hypertension, and chronic kidney disease.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1007/978-3-211-99390-3_106", xref="DOI:10.1152/physiol.00008.2011", xref="DOI:10.1152/physrev.00011.2019", xref="DOI:10.2215/CJN.08880914", xref="DOI:10.3390/diseases2020071"} [Term] id: CL:1001433 name: epithelial cell of exocrine pancreas def: "An epithelial cell of the exocrine pancreas." [GOC:tfm] subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "exocrine pancreas cell" EXACT [] xref: FMA:70986 is_a: CL:0000083 ! epithelial cell of pancreas intersection_of: CL:0000066 ! epithelial cell intersection_of: BFO:0000050 UBERON:0000017 ! part of exocrine pancreas relationship: BFO:0000050 UBERON:0000017 ! part of exocrine pancreas property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:1001434 name: olfactory bulb interneuron def: "A neuron residing in the olfactory bulb that serve to process and refine signals arising from olfactory sensory neurons" [PMID:18603310] subset: human_subset subset: mouse_subset is_a: CL:0000099 ! interneuron is_a: CL:0000101 ! sensory neuron intersection_of: CL:0000099 ! interneuron intersection_of: RO:0002100 UBERON:0002264 ! has soma location olfactory bulb relationship: BFO:0000050 UBERON:0002264 ! part of olfactory bulb relationship: RO:0002100 UBERON:0002264 ! has soma location olfactory bulb property_value: skos:prefLabel "olfactory bulb interneuron" xsd:string [Term] id: CL:1001435 name: periglomerular cell def: "The small neuron in the glomerular layer of the olfactory bulb whose dendrites arborize within a glomerulus, where it receives synaptic input from olfactory receptor cell axon terminals, and also engages in dendrodendritic interactions with mitral and tufted cell dendrites; uses both GABA and dopamine as a neurotransmitter." [MP:0009943] subset: human_subset subset: mouse_subset synonym: "glomerular layer cell" EXACT [NIFEXT:122] synonym: "olfactory bulb (accessory) glomerular layer cell" EXACT [NIFEXT:122] synonym: "olfactory bulb glomerular layer cell" EXACT [NIFEXT:122] synonym: "olfactory bulb glomerularal cell" EXACT [MP:0009943] synonym: "olfactory bulb periglomerular cell" EXACT [] xref: BTO:0003796 xref: NIFEXT:122 is_a: CL:1001434 ! olfactory bulb interneuron relationship: RO:0002100 UBERON:0005377 ! has soma location olfactory bulb glomerular layer [Term] id: CL:1001436 name: hair-tylotrich neuron def: "The subcutaneous mechanoreceptors that innervate tylotrich hair follicles." [MP:0000977] subset: human_subset subset: mouse_subset is_a: CL:0002487 ! cutaneous/subcutaneous mechanoreceptor cell [Term] id: CL:1001437 name: hair-down neuron def: "The subcutaneous mechanoreceptors that innervate vellus hairs." [MP:0000979] subset: human_subset subset: mouse_subset is_a: CL:0002487 ! cutaneous/subcutaneous mechanoreceptor cell [Term] id: CL:1001451 name: sensory neuron of dorsal root ganglion def: "A sensory neuron of the dorsal root ganglia that senses body position and sends information about how much the muscle is stretched to the spinal cord." [MP:0004297] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "proprioceptive neuron" EXACT [MP:0004297] is_a: CL:0000006 ! neuronal receptor cell is_a: CL:3000004 ! peripheral sensory neuron is_a: CL:4023168 ! somatosensory neuron intersection_of: CL:0000101 ! sensory neuron intersection_of: RO:0002100 UBERON:0000044 ! has soma location dorsal root ganglion relationship: BFO:0000050 UBERON:0000044 ! part of dorsal root ganglion relationship: RO:0002100 UBERON:0000044 ! has soma location dorsal root ganglion [Term] id: CL:1001474 name: medium spiny neuron def: "An inhibitory, GABAergic projection neuron in the striatum that integrates glutamatergic signals arising from the cerebral cortex and thalamus." [doi:10.1073/pnas.242428599, MP:0008462] comment: Direct genetic lineage tracing in mice, including Dlx-based and Sp9-Cre fate mapping, demonstrates that medium spiny neurons (MSNs) originate from progenitors in the lateral ganglionic eminence (LGE), with labeled cells migrating from LGE to the striatum and expressing MSN markers such as FOXP1 and CTIP2. {xref="doi:10.1523/JNEUROSCI.20-16-06063.2000", xref="doi:10.1038/s41420-022-01088-0"} subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "gamma-aminobutyric acid (GABA)ergic spiny projection neuron" EXACT [doi:10.1073/pnas.242428599] synonym: "gamma-aminobutyric acid ergic spiny projection neuron" EXACT [doi:10.1073/pnas.242428599] synonym: "medium-sized densely spiny neuron" RELATED [BTO:0004778] synonym: "striatal medium spiny neuron" EXACT [GO:0021773] xref: BTO:0004778 is_a: CL:0000617 ! GABAergic neuron is_a: CL:4023035 ! lateral ganglionic eminence derived neuron relationship: RO:0002100 UBERON:0000369 ! has soma location corpus striatum property_value: RO:0002175 NCBITaxon:9606 property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_1001474" xsd:string {name="medium spiny neuron on CELLxGENE CellGuide"} property_value: terms:description "Medium spiny neurons, constituting the main type of neurons found in the striatum of the brain, are key players in various pathways that facilitate a multitude of cognitive functions. Projecting dendrites laden with spines, these cells are equipped to receive a wide range of synaptic input, mainly from the cerebral cortex and the thalamus. The \"medium\" and \"spiny\" descriptive parts of the name stem from the neurons' size, which is intermediate when compared to other neurons, and the presence of numerous spines on the dendrites, which serve as critical points for synaptic connections.\nThe primary function of medium spiny neurons lies within motor control and reward pathways, which are fundamental aspects of the basal ganglia circuitry. They act by receiving and integrating various excitatory and inhibitory inputs to generate a resultant inhibitory output, generally towards other basal ganglia structures. This inhibitory output is crucial to the balance within the basal ganglia system, which regulates voluntary movements, habitual behaviors, and cognitive and emotional functionalities. The medium spiny neurons act through the use of the neurotransmitter gamma-aminobutyric acid (GABA) and express high levels of dopamine D1 or D2 receptors, which facilitate communication within the brain's dopamine system.\nDisruptions or malfunctions in medium spiny neurons have been associated with several neurological and psychiatric disorders. For instance, in Huntington's disease, these neurons display a specific vulnerability, leading to motor control issues, cognitive decline, and psychiatric symptoms. Similarly, these neurons play critical roles in substance addiction, as the neurons' reward pathways can become sensitized or desensitized due to drug abuse.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1007/978-3-7091-0932-8_18", xref="DOI:10.1007/s13311-012-0112-2", xref="DOI:10.1016/j.tins.2007.03.008", xref="DOI:10.1523/JNEUROSCI.3833-10.2011", xref="DOI:10.3389/fnbeh.2011.00047"} [Term] id: CL:1001502 name: mitral cell def: "The large glutaminergic nerve cells whose dendrites synapse with axons of the olfactory receptor neurons in the glomerular layer of the olfactory bulb, and whose axons pass centrally in the olfactory tract to the olfactory cortex." [MP:0009954] subset: human_subset subset: mouse_subset is_a: CL:1001434 ! olfactory bulb interneuron relationship: RO:0002100 UBERON:0004186 ! has soma location olfactory bulb mitral cell layer property_value: skos:prefLabel "mitral cell" xsd:string [Term] id: CL:1001503 name: olfactory bulb tufted cell def: "The principal glutaminergic neuron located in the outer third of the external plexiform layer of the olfactory bulb; a single short primary dendrite traverses the outer external plexiform layer and terminates within an olfactory glomerulus in a tuft of branches, where it receives the input from olfactory receptor neuron axon terminals; axons of the tufted cells transfer information to a number of areas in the brain, including the piriform cortex, entorhinal cortex, olfactory tubercle, and amygdala." [MP:0009955] subset: human_subset subset: mouse_subset is_a: CL:2000029 ! central nervous system neuron relationship: RO:0002100 UBERON:0005376 ! has soma location olfactory bulb external plexiform layer property_value: skos:prefLabel "olfactory bulb tufted cell" xsd:string [Term] id: CL:1001505 name: parvocellular neurosecretory cell def: "The secretory neurons of the paraventricular nucleus that synthesize and secrete vasopressin, corticotropin-releasing factor (CRF) and thyrotropin-releasing hormone (TRH) into blood vessels in the hypothalamo-pituitary portal system." [MP:0010125] subset: human_subset subset: mouse_subset synonym: "parvocellular neuron" EXACT [] synonym: "parvocellular neurosecretory neuron" EXACT [] is_a: CL:0000165 ! neuroendocrine cell is_a: CL:0000167 ! peptide hormone secreting cell is_a: CL:0012001 ! neuron of the forebrain is_a: CL:2000030 ! hypothalamus cell relationship: BFO:0000050 UBERON:0001930 ! part of paraventricular nucleus of hypothalamus relationship: RO:0002215 GO:0030103 ! capable of vasopressin secretion [Term] id: CL:1001509 name: glycinergic neuron def: "The neurons that utilize glycine as a neurotransmitter." [MP:0010385] subset: cellxgene_subset subset: human_subset subset: mouse_subset xref: FBbt:00048032 {sssom:mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"} xref: ZFA:0009396 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: CL:0000151 ! secretory cell is_a: CL:0000540 ! neuron intersection_of: CL:0000540 ! neuron intersection_of: RO:0002215 GO:0061537 ! capable of glycine secretion, neurotransmission relationship: RO:0002215 GO:0061537 ! capable of glycine secretion, neurotransmission property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_1001509" xsd:string {name="glycinergic neuron on CELLxGENE CellGuide"} property_value: terms:description "Glycinergic neurons are a specialized type of neuron that primarily utilizes the inhibitory neurotransmitter glycine to transmit signals within the nervous system. Originating from the term 'glycine' and 'ergic' (pertaining to activity), glycinergic neurons contain and release glycine which acts on specific receptors, known as glycine receptors, found on the surface of neuron cells. Glycinergic neurons are predominantly found in the spinal cord and brainstem, but also exist in the retina and other parts of the brain.\nThese neurons are critical to the inhibitory control of neuronal networks, helping to regulate excitation and maintaining neuronal stability. They play a primary role in modulating and controlling motor and sensory information within the nervous system. In general, when a glycinergic neuron fires, it releases glycine, which binds to glycine receptors on a nearby neuron. This binding causes the neuron membrane to hyperpolarize, subsequently reducing the probability of the neuron firing an action potential, which in essence dampens or inhibits the neuron from transmitting further signals. This function plays a vital role in preventing overexcitation, which may lead to neuronal damage or neurodegenerative conditions.\nMoreover, glycinergic neurons are integral to certain sensory processes and motor coordination. In the auditory system, these neurons aid in the localization of sound, and in the spinal cord, they are involved in the regulation of motor reflexes and rhythms. Any dysfunction in the glycinergic system can cause serious neurological conditions, such as hyperekplexia, characterized by increased startle responses and periodic bouts of rigidity, and some forms of chronic pain.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1007/BF02740653", xref="DOI:10.1016/j.pneurobio.2010.04.008", xref="DOI:10.1042/NS20160009", xref="DOI:10.1093/brain/awx289", xref="DOI:10.1111/j.1399-6576.2005.00786.x"} [Term] id: CL:1001516 name: intestinal enteroendocrine cell def: "The various hormone- or neurotransmitter-secreting cells present throughout the mucosa of the intestinal tract." [MP:0010802] subset: cellxgene_subset subset: human_subset subset: mouse_subset is_a: CL:0000164 ! enteroendocrine cell is_a: CL:0002563 ! intestinal epithelial cell intersection_of: CL:0000164 ! enteroendocrine cell intersection_of: BFO:0000050 UBERON:0001277 ! part of intestinal epithelium relationship: RO:0002207 CL:4052006 ! directly develops from intestinal enteroendocrine progenitor property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_1001516" xsd:string {name="intestinal enteroendocrine cell on CELLxGENE CellGuide"} property_value: terms:description "Intestinal enteroendocrine cells are a highly specialized cell type found within the gastrointestinal epithelium. They account for approximately 1% of the intestinal epithelial cells in what is known as the largest endocrine organ in the human body. Intestinal enteroendocrine cells exhibit an exceptional diversity, both in terms of their secretory products and their distribution along the intestines, varying from the small intestine to the colon. \nThe primary function of intestinal enteroendocrine cells is to maintain gut physiology and homeostasis. They are known for their hormone production and are the source of numerous bioactive molecules including somatostatin, serotonin, cholecystokinin, glucose-dependent insulinotropic peptide, motilin, neurotensin, and others. These hormones and neuropeptides act in autocrine, paracrine, or endocrine signaling, impacting various functions including intestinal motility, secretion, nutrient absorption, and gut barrier functions.\nIntestinal enteroendocrine cells also serve as the body's frontline of defense, playing an integral role in surveillance against lumen-occurring hazards including pathogen attack. Enteroendocrine cells are divided into ‘closed type’ and ‘open type’. Closed type cells are located close to the basal membrane and do not reach the lumen of the gut. In contrast, the apical side of the open-type intestinal enteroendocrine cells is directly exposed to luminal contents and thus can recognize bacterial metabolites and dietary nutrients. In response, these cells can modulate the immune system responses and thereby function as a key communicator between the gut microbiota and the host.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1016/j.coph.2013.09.008", xref="DOI:10.1038/mi.2017.73", xref="DOI:10.1038/s41574-019-0168-8", xref="DOI:10.1111/j.1365-2613.2011.00767.x", xref="DOI:10.1146/annurev-physiol-021115-105439"} [Term] id: CL:1001517 name: stomach enteroendocrine cell def: "The various hormone- or neurotransmitter-secreting cells present throughout the mucosa of the stomach." [MP:0010803] subset: human_subset subset: mouse_subset is_a: CL:0000164 ! enteroendocrine cell is_a: CL:0002178 ! epithelial cell of stomach intersection_of: CL:0000164 ! enteroendocrine cell intersection_of: BFO:0000050 UBERON:0000945 ! part of stomach [Term] id: CL:1001561 name: vomeronasal sensory neuron def: "Chemosensitive cells that innervate the vomernasal organ epithelium and are responsible for receiving and transmitting pheromone signals." [MP:0011679] subset: human_subset subset: mouse_subset is_a: BFO:0000002 is_a: CL:0000101 ! sensory neuron intersection_of: CL:0000101 ! sensory neuron intersection_of: RO:0002100 UBERON:0002255 ! has soma location vomeronasal organ intersection_of: RO:0013007 UBERON:0003367 ! has sensory dendrite in epithelium of vomeronasal organ relationship: RO:0002100 UBERON:0002255 ! has soma location vomeronasal organ relationship: RO:0013007 UBERON:0003367 ! has sensory dendrite in epithelium of vomeronasal organ [Term] id: CL:1001566 name: obsolete bronchioalveolar stem cells def: "OBSOLETE. A respiratory stem cell found at the junction of the terminal (conductive) bronchiole and the respiratory bronchiole, which gives rise to alveolar cell types and club cells in response to lung injury." [MP:0011691] comment: Duplicated term - merged into CL:0002638 property_value: IAO:0000233 https://github.com/obophenotype/cell-ontology/issues/1443 is_obsolete: true replaced_by: CL:0002638 [Term] id: CL:1001567 name: lung endothelial cell def: "Any endothelial cell of vascular tree that is part of some lung." [FBC:Autogenerated] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "endothelial cell of lung" RELATED [] synonym: "pulmonary vessel endothelial cell" RELATED [] is_a: CL:0002139 ! endothelial cell of vascular tree intersection_of: CL:0002139 ! endothelial cell of vascular tree intersection_of: BFO:0000050 UBERON:0002048 ! part of lung relationship: BFO:0000050 UBERON:0000102 ! part of lung vasculature [Term] id: CL:1001568 name: pulmonary artery endothelial cell def: "Any endothelial cell of vascular tree that is part of some pulmonary artery." [FBC:Autogenerated] subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "PAEC cell" RELATED [BTO:0001141] xref: BTO:0001141 is_a: CL:1000413 ! endothelial cell of artery intersection_of: CL:0002139 ! endothelial cell of vascular tree intersection_of: BFO:0000050 UBERON:0002012 ! part of pulmonary artery relationship: BFO:0000050 UBERON:0005317 ! part of pulmonary artery endothelium property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:1001569 name: hippocampal interneuron def: "An interneuron with a soma found in the hippocampus." [GOC:pr] subset: cellxgene_subset subset: human_subset subset: mouse_subset xref: FMA:84777 is_a: CL:0002608 ! hippocampal neuron is_a: CL:0008031 ! cortical interneuron intersection_of: CL:0000099 ! interneuron intersection_of: RO:0002100 UBERON:0002421 ! has soma location hippocampal formation [Term] id: CL:1001571 name: hippocampal pyramidal neuron def: "A pyramidal neuron with a soma found in the hippocampus." [GOC:pr, PMID:19342486] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "hippocampus (CA) pyramidal cell" NARROW [NIFSTD:sao131261273] synonym: "hippocampus (CA) pyramidal neuron" NARROW [NIFSTD:sao131261273] xref: NIFSTD:sao131261273 xref: SAO:sao131261273 is_a: CL:0002608 ! hippocampal neuron is_a: CL:4023111 ! cerebral cortex pyramidal neuron intersection_of: CL:0000598 ! pyramidal neuron intersection_of: RO:0002100 UBERON:0002421 ! has soma location hippocampal formation relationship: BFO:0000050 UBERON:0002313 ! part of hippocampus pyramidal layer [Term] id: CL:1001572 name: colon endothelial cell def: "A vascular endothelial cell found in colon blood vessels." [https://orcid.org/0000-0001-5208-3432, NPX:PDR] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "colon endothelial cells" RELATED OMO:0003004 [CALOHA:TS-2397] synonym: "colonic endothelial cell" RELATED [CALOHA:TS-2397] xref: CALOHA:TS-2397 is_a: CL:0000131 ! gut endothelial cell intersection_of: CL:0000115 ! endothelial cell intersection_of: BFO:0000050 UBERON:0001155 ! part of colon relationship: BFO:0000050 UBERON:0013695 ! part of colon endothelium [Term] id: CL:1001573 name: nasopharyngeal epithelial cell def: "Cell of the nasopharyngeal epithelium." [NPX:PDR] subset: human_subset subset: mouse_subset synonym: "nasopharynx respiratory epithelial cells" RELATED [CALOHA:TS-2398] xref: CALOHA:TS-2398 is_a: CL:0002251 ! epithelial cell of alimentary canal is_a: CL:0002631 ! epithelial cell of upper respiratory tract intersection_of: CL:0000066 ! epithelial cell intersection_of: BFO:0000050 UBERON:0001728 ! part of nasopharynx relationship: BFO:0000050 UBERON:0001951 ! part of epithelium of nasopharynx [Term] id: CL:1001575 name: uterine cervix squamous cell def: "Squamous cell of uterine cervix epithelium." [NPX:PDR] subset: human_subset subset: mouse_subset synonym: "cervix squamous cell" RELATED [CALOHA:TS-1251] synonym: "cervix squamous epithelial cell" RELATED [CALOHA:TS-1251] synonym: "cervix, uterine squamous epithelial cells" RELATED [CALOHA:TS-1251] synonym: "uterine cervix squamous epithelial cell" RELATED [CALOHA:TS-1251] synonym: "uterine cervix squamous epithelial cells" RELATED [CALOHA:TS-1251] xref: CALOHA:TS-1251 is_a: CL:0000076 ! squamous epithelial cell is_a: CL:0002535 ! epithelial cell of cervix intersection_of: CL:0000076 ! squamous epithelial cell intersection_of: BFO:0000050 UBERON:0000002 ! part of uterine cervix [Term] id: CL:1001576 name: oral mucosa squamous cell def: "Squamous cell of oral epithelium." [NPX:PDR] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "oral cavity mucosa squamous cell" RELATED [CALOHA:TS-1252] synonym: "oral cavity mucosa squamous epithelial cell" RELATED [CALOHA:TS-1252] synonym: "oral mucosa squamous epithelial cell" RELATED [CALOHA:TS-1252] synonym: "oral mucosa squamous epithelial cells" RELATED [CALOHA:TS-1252] xref: CALOHA:TS-1252 is_a: CL:0000076 ! squamous epithelial cell is_a: CL:0002251 ! epithelial cell of alimentary canal intersection_of: CL:0000076 ! squamous epithelial cell intersection_of: BFO:0000050 UBERON:0002424 ! part of oral epithelium relationship: BFO:0000050 UBERON:0002424 ! part of oral epithelium [Term] id: CL:1001577 name: tonsil squamous cell def: "Squamous cell of tonsil epithelium." [NPX:PDR] subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "tonsil squamous epithelial cell" RELATED [CALOHA:TS-1253] synonym: "tonsil squamous epithelial cells" RELATED [CALOHA:TS-1253] synonym: "tonsillar squamous cell" RELATED [CALOHA:TS-1253] synonym: "tonsillar squamous epithelial cell" RELATED [CALOHA:TS-1253] xref: CALOHA:TS-1253 is_a: CL:0000076 ! squamous epithelial cell is_a: CL:0002251 ! epithelial cell of alimentary canal intersection_of: CL:0000076 ! squamous epithelial cell intersection_of: BFO:0000050 UBERON:0002372 ! part of tonsil relationship: BFO:0000050 UBERON:0013696 ! part of tonsil epithelium property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:1001578 name: vagina squamous cell def: "Squamous cell of vaginal epithelium." [NPX:PDR] subset: human_subset subset: mouse_subset synonym: "vagina squamous epithelial cell" RELATED [CALOHA:TS-1254] synonym: "vagina squamous epithelial cells" RELATED [CALOHA:TS-1254] synonym: "vaginal squamous cell" RELATED [CALOHA:TS-1254] synonym: "vaginal squamous epithelial cell" RELATED [CALOHA:TS-1254] xref: CALOHA:TS-1254 is_a: CL:0000076 ! squamous epithelial cell intersection_of: CL:0000076 ! squamous epithelial cell intersection_of: BFO:0000050 UBERON:0000996 ! part of vagina relationship: BFO:0000050 UBERON:0001344 ! part of epithelium of vagina [Term] id: CL:1001579 name: cerebral cortex glial cell def: "Glial cell of cerebral cortex." [NPX:PDR] subset: human_subset subset: mouse_subset synonym: "brain cortex glial cell" RELATED [CALOHA:TS-1256] synonym: "cerebral cortex glial cells" RELATED [CALOHA:TS-1256] synonym: "cerebrum cortex glial cell" RELATED [CALOHA:TS-1256] xref: CALOHA:TS-1256 is_a: CL:0000125 ! glial cell intersection_of: CL:0000125 ! glial cell intersection_of: BFO:0000050 UBERON:0000956 ! part of cerebral cortex relationship: BFO:0000050 UBERON:0000956 ! part of cerebral cortex [Term] id: CL:1001580 name: hippocampal glial cell def: "A glial cell that is part of the hippocampus." [NPX:PDR] subset: human_subset subset: mouse_subset synonym: "hippocampus glial cell" EXACT [CALOHA:TS-1257] synonym: "hippocampus neuroglial cell" EXACT [CALOHA:TS-1257] xref: CALOHA:TS-1257 is_a: CL:1001579 ! cerebral cortex glial cell intersection_of: CL:0000125 ! glial cell intersection_of: BFO:0000050 UBERON:0002421 ! part of hippocampal formation relationship: BFO:0000050 UBERON:0002421 ! part of hippocampal formation [Term] id: CL:1001581 name: lateral ventricle glial cell def: "Glial cell of lateral ventricle." [NPX:PDR] subset: human_subset subset: mouse_subset synonym: "lateral ventricle glial cells" RELATED [CALOHA:TS-1258] xref: CALOHA:TS-1258 is_a: CL:0000125 ! glial cell intersection_of: CL:0000125 ! glial cell intersection_of: BFO:0000050 UBERON:0002285 ! part of telencephalic ventricle relationship: BFO:0000050 UBERON:0002285 ! part of telencephalic ventricle [Term] id: CL:1001582 name: lateral ventricle neuron def: "Neuron of lateral ventricle." [NPX:PDR] subset: human_subset subset: mouse_subset synonym: "lateral ventricle neural cell" RELATED [CALOHA:TS-1261] synonym: "lateral ventricle neuronal cell" RELATED [CALOHA:TS-1261] synonym: "lateral ventricle neuronal cells" RELATED [CALOHA:TS-1261] xref: CALOHA:TS-1261 is_a: CL:0012001 ! neuron of the forebrain intersection_of: CL:0000540 ! neuron intersection_of: RO:0002100 UBERON:0002285 ! has soma location telencephalic ventricle relationship: RO:0002100 UBERON:0002285 ! has soma location telencephalic ventricle [Term] id: CL:1001583 name: obsolete breast adipocyte def: "OBSOLETE: Adipocytes found in the subcutaneous adipose tissue of breast. The breast consists of three main components, the skin, the subcutaneous adipose tissue and the functional glandular tissue that comprises both parenchyma and stroma." [HPA:Breast] synonym: "breast adipocytes" RELATED [CALOHA:TS-2377] is_obsolete: true replaced_by: CL:0002617 [Term] id: CL:1001585 name: appendix glandular cell def: "Glandular cell of appendix epithelium. Example: Goblet cells; enterocytes or absorptive cells; enteroendocrine and M cells." [NPX:PDR] subset: human_subset subset: mouse_subset synonym: "appendix glandular cells" RELATED [CALOHA:TS-1271] synonym: "caecal appendix glandular cell" RELATED [CALOHA:TS-1271] synonym: "cecal appendix glandular cell" RELATED [CALOHA:TS-1271] synonym: "vermiform appendix glandular cell" RELATED [CALOHA:TS-1271] xref: CALOHA:TS-1271 is_a: CL:0002658 ! glandular cell of the large intestine is_a: CL:1000405 ! epithelial cell of appendix intersection_of: CL:0000150 ! glandular secretory epithelial cell intersection_of: BFO:0000050 UBERON:0001154 ! part of vermiform appendix [Term] id: CL:1001586 name: mammary gland glandular cell def: "Glandular cell of mammary epithelium. Example: glandular cells of large and intermediate ducts, glandular cells in terminal ducts." [HPA:HPA, NPX:PDR] subset: human_subset subset: mouse_subset synonym: "breast glandular cell" RELATED [CALOHA:TS-1272] synonym: "breast glandular cells" RELATED [CALOHA:TS-1272] synonym: "mammary glandular cell" RELATED [CALOHA:TS-1272] xref: CALOHA:TS-1272 is_a: CL:0000150 ! glandular secretory epithelial cell is_a: CL:0000152 ! exocrine cell is_a: CL:0002327 ! mammary gland epithelial cell intersection_of: CL:0000150 ! glandular secretory epithelial cell intersection_of: BFO:0000050 UBERON:0001911 ! part of mammary gland relationship: BFO:0000050 UBERON:0003244 ! part of epithelium of mammary gland [Term] id: CL:1001587 name: uterine cervix secretory cell def: "Glandular cell of uterine cervix epithelium." [NPX:PDR] subset: human_subset subset: mouse_subset synonym: "cervix glandular cell" RELATED [CALOHA:TS-1273] synonym: "cervix, uterine glandular cell" RELATED [CALOHA:TS-1273] synonym: "cervix, uterine glandular cells" RELATED [CALOHA:TS-1273] synonym: "uterine cervix glandular cell" RELATED [] xref: CALOHA:TS-1273 is_a: CL:0002535 ! epithelial cell of cervix is_a: CL:1001591 ! oviduct secretory cell intersection_of: CL:1100001 ! secretory epithelial cell intersection_of: BFO:0000050 UBERON:0000002 ! part of uterine cervix [Term] id: CL:1001588 name: colon glandular cell def: "Glandular cell of colon epithelium. Example: Goblet cells; enterocytes or absorptive cells; enteroendocrine and M cells." [NPX:PDR] subset: human_subset subset: mouse_subset synonym: "colon glandular cells" RELATED [CALOHA:TS-1274] xref: CALOHA:TS-1274 is_a: CL:0002658 ! glandular cell of the large intestine is_a: CL:0011108 ! colon epithelial cell intersection_of: CL:0000150 ! glandular secretory epithelial cell intersection_of: BFO:0000050 UBERON:0001155 ! part of colon [Term] id: CL:1001589 name: duodenum secretory cell def: "Glandular cell of duodenal epithelium. Example: Enterocytes, Goblet cells, enteroendocrine cells; Paneth cells; M cells; Brunner's gland cell." [NPX:PDR] subset: human_subset subset: mouse_subset synonym: "duodenum glandular cells" NARROW [CALOHA:TS-1275] xref: CALOHA:TS-1275 is_a: CL:1001598 ! small intestine secretory cell intersection_of: CL:1100001 ! secretory epithelial cell intersection_of: BFO:0000050 UBERON:0002114 ! part of duodenum relationship: BFO:0000050 UBERON:0008346 ! part of duodenal epithelium [Term] id: CL:1001590 name: epididymis secretory cell def: "Glandular cell of epididymal epithelium." [NPX:PDR] subset: human_subset subset: mouse_subset synonym: "epididymal glandular cell" RELATED [CALOHA:TS-1276] synonym: "epididymis glandular cell" RELATED [CALOHA:TS-1276] xref: CALOHA:TS-1276 is_a: CL:0000068 ! duct epithelial cell is_a: CL:1100001 ! secretory epithelial cell intersection_of: CL:1100001 ! secretory epithelial cell intersection_of: BFO:0000050 UBERON:0001301 ! part of epididymis relationship: BFO:0000050 UBERON:0004544 ! part of epididymis epithelium [Term] id: CL:1001591 name: oviduct secretory cell def: "Glandular cell of oviduct epithelium. Example: peg cells, ciliated cells." [HPA:HPA, NPX:PDR] subset: human_subset subset: mouse_subset synonym: "fallopian tube glandular cell" RELATED [CALOHA:TS-1277] synonym: "fallopian tube glandular cells" RELATED [CALOHA:TS-1277] synonym: "oviduct glandular cell" RELATED [] synonym: "uterine tube glandular cell" RELATED [CALOHA:TS-1277] xref: CALOHA:TS-1277 is_a: CL:1100001 ! secretory epithelial cell intersection_of: CL:1100001 ! secretory epithelial cell intersection_of: BFO:0000050 UBERON:0000993 ! part of oviduct relationship: BFO:0000050 UBERON:0004804 ! part of oviduct epithelium [Term] id: CL:1001592 name: gallbladder glandular cell def: "Glandular cell of gallbladder epithelium." [NPX:PDR] subset: human_subset subset: mouse_subset synonym: "gall bladder glandular cell" EXACT [FMA:7202] synonym: "gall bladder glandular cells" RELATED [CALOHA:TS-1278] synonym: "gallbladder glandular cells" RELATED [CALOHA:TS-1278] xref: CALOHA:TS-1278 is_a: CL:0000150 ! glandular secretory epithelial cell is_a: CL:1000415 ! epithelial cell of gallbladder intersection_of: CL:0000150 ! glandular secretory epithelial cell intersection_of: BFO:0000050 UBERON:0002110 ! part of gallbladder relationship: BFO:0000050 UBERON:0002029 ! part of epithelium of gall bladder [Term] id: CL:1001593 name: parathyroid glandular cell def: "Glandular (secretory) cell of parathyroid epithelium." [HPA:HPA, NPX:PDR] subset: human_subset subset: mouse_subset synonym: "parathyroid gland glandular cell" RELATED [CALOHA:TS-1279] synonym: "parathyroid gland glandular cells" RELATED [CALOHA:TS-1279] xref: CALOHA:TS-1279 is_a: CL:0000150 ! glandular secretory epithelial cell is_a: CL:0002260 ! epithelial cell of parathyroid gland intersection_of: CL:0000150 ! glandular secretory epithelial cell intersection_of: BFO:0000050 UBERON:0001132 ! part of parathyroid gland [Term] id: CL:1001595 name: rectum glandular cell def: "Glandular cell of rectal epithelium. Example: Goblet cell; enterocytes or absorptive cells; enteroendocrine and M cells." [NPX:PDR] subset: human_subset subset: mouse_subset synonym: "rectal glandular cell" RELATED [CALOHA:TS-1281] synonym: "rectum glandular cells" RELATED [CALOHA:TS-1281] xref: CALOHA:TS-1281 is_a: CL:0002658 ! glandular cell of the large intestine intersection_of: CL:0000150 ! glandular secretory epithelial cell intersection_of: BFO:0000050 UBERON:0001052 ! part of rectum relationship: BFO:0000050 UBERON:0003354 ! part of epithelium of rectum [Term] id: CL:1001596 name: salivary gland glandular cell def: "Glandular cell of salivary gland. Example: Serous cells, mucous cells, cuboidal epithelial cells of the intercalated ducts, simple cuboidal epithelium of the striated ducts, epithelial cells of excretory ducts." [HPA:HPA, NPX:PDR] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "salivary gland glandular cells" RELATED [CALOHA:TS-1282] xref: CALOHA:TS-1282 is_a: CL:0000150 ! glandular secretory epithelial cell is_a: CL:0000152 ! exocrine cell is_a: CL:0002251 ! epithelial cell of alimentary canal is_a: CL:0009005 ! salivary gland cell intersection_of: CL:0000150 ! glandular secretory epithelial cell intersection_of: BFO:0000050 UBERON:0001044 ! part of saliva-secreting gland relationship: BFO:0000050 UBERON:0004809 ! part of salivary gland epithelium [Term] id: CL:1001597 name: seminal vesicle glandular cell def: "Glandular cell of seminal vesicle epithelium." [NPX:PDR] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "seminal vesicle glandular cells" RELATED [CALOHA:TS-1283] xref: CALOHA:TS-1283 is_a: CL:0000068 ! duct epithelial cell is_a: CL:0000150 ! glandular secretory epithelial cell intersection_of: CL:0000150 ! glandular secretory epithelial cell intersection_of: BFO:0000050 UBERON:0000998 ! part of seminal vesicle relationship: BFO:0000050 UBERON:0004805 ! part of seminal vesicle epithelium property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_1001597" xsd:string {name="seminal vesicle glandular cell on CELLxGENE CellGuide"} property_value: terms:description "Seminal vesicle glandular cells belong to a specialized group of epithelial cells that form the internal lining of the seminal vesicles, a pair of male reproductive organs. These cells are located within the complex tubuloalveolar glands that make up the seminal vesicles and are known for their unique pseudostratified columnar epithelium structure. \nThe primary function of these cells is the secretion of a variety of substances that ultimately constitute around 70% of the fluid volume of semen. Seminal cells produce a high-fructose fluid that serves as an energy source for the spermatozoa and promotes their motility. They also secrete other essential substances like proteins, enzymes, vitamin C, prostaglandins, and various other compounds. Collectively, these substances help in the nourishment, protection, and transportation of the spermatozoa throughout the male reproductive system and during the ejaculation process.\nSecondary to the production of seminal fluid, the seminal vesicle glandular cells also play a role in the contraction of the seminal vesicles during ejaculation. The contraction of these glands, induced by sympathetic nerves, ensures the efficient propulsion of the seminal fluid mixed with spermatozoa into the ejaculatory ducts and subsequently to the urethra. Notably, any malfunction or pathological condition affecting these cells can impact male fertility, emphasizing the importance of understanding the intricate functions of seminal vesicle glandular cells in maintaining the healthy physiological function of male reproduction.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1007/978-3-030-32300-4_26", xref="DOI:10.1007/s00265-006-0178-0", xref="DOI:10.1111/j.1439-0272.1992.tb02636.x", xref="https://www.ncbi.nlm.nih.gov/books/NBK499854/", xref="https://www.sciencedirect.com/topics/veterinary-science-and-veterinary-medicine/seminal-vesicle"} [Term] id: CL:1001598 name: small intestine secretory cell def: "A glandular cell found in the epithelium of the small intestine. Example: Enterocytes, Goblet cells, enteroendocrine cells; Paneth cells; M cells; Somatostatin-secreting Cells (D-cells) ." [NCI_Thesaurus:Small_Intestinal_Glandular_Cell, NPX:PDR] subset: human_subset subset: mouse_subset synonym: "small bowel glandular cell" RELATED [CALOHA:TS-1286] synonym: "small intestinal glandular cell" NARROW [CALOHA:TS-1286] synonym: "small intestine glandular cells" RELATED [CALOHA:TS-1286] xref: CALOHA:TS-1286 xref: FMA:86928 is_a: CL:0002254 ! epithelial cell of small intestine is_a: CL:1100001 ! secretory epithelial cell intersection_of: CL:1100001 ! secretory epithelial cell intersection_of: BFO:0000050 UBERON:0002108 ! part of small intestine relationship: BFO:0000050 UBERON:0001902 ! part of epithelium of small intestine [Term] id: CL:1001599 name: pancreas exocrine glandular cell def: "Glandular cell of exocrine pancreas epithelium. Example: pancreatic acinar cell, glandular cells in pancreatic canaliculi, glandular cells in pancreatic ducts." [HPA:HPA, NPX:PDR] subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "exocrine pancreas glandular cell" RELATED [CALOHA:TS-1242] synonym: "pancreas exocrine glandular cells" RELATED [CALOHA:TS-1242] xref: BTO:0000028 xref: CALOHA:TS-1242 is_a: CL:0000150 ! glandular secretory epithelial cell is_a: CL:0000152 ! exocrine cell is_a: CL:1001433 ! epithelial cell of exocrine pancreas intersection_of: CL:0000150 ! glandular secretory epithelial cell intersection_of: BFO:0000050 UBERON:0000017 ! part of exocrine pancreas relationship: BFO:0000050 UBERON:0013697 ! part of exocrine pancreas epithelium property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:1001601 name: adrenal gland glandular cell def: "Hormone secreting cell located in the cortex of adrenal gland. Glandular cells in the adrenal cortex secrete mineralocorticoids, glucocorticoids and androgens." [NPX:PDR] subset: human_subset subset: mouse_subset synonym: "adrenal gland glandular cells" RELATED [CALOHA:TS-2177] synonym: "adrenal glandular cell" RELATED [CALOHA:TS-2177] synonym: "suprarenal gland glandular cell" RELATED [CALOHA:TS-2177] xref: CALOHA:TS-2177 is_a: CL:0000150 ! glandular secretory epithelial cell intersection_of: CL:0000150 ! glandular secretory epithelial cell intersection_of: BFO:0000050 UBERON:0001235 ! part of adrenal cortex relationship: BFO:0000050 UBERON:0001235 ! part of adrenal cortex [Term] id: CL:1001602 name: cerebral cortex endothelial cell def: "A distinct endothelial cell forming the walls of the capillaries within the cerebral cortex." [NPX:PDR] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "cerebral cortex endothelial cells" RELATED [CALOHA:TS-2372] synonym: "endothelial cells of cerebral cortex" RELATED [CALOHA:TS-2372] xref: CALOHA:TS-2372 is_a: CL:0000115 ! endothelial cell is_a: CL:0002319 ! neural cell intersection_of: CL:0000115 ! endothelial cell intersection_of: BFO:0000050 UBERON:0000956 ! part of cerebral cortex relationship: BFO:0000050 UBERON:0000956 ! part of cerebral cortex relationship: BFO:0000050 UBERON:0013694 ! part of brain endothelium property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_1001602" xsd:string {name="cerebral cortex endothelial cell on CELLxGENE CellGuide"} property_value: terms:description "Cerebral cortex endothelial cells are unique endothelial cells responsible for the formation and regulation of the blood-brain barrier (BBB), a specialized structure that separates the circulating blood from the cerebral neural tissue. These cells line the inner surface of nearly all blood vessels that irrigate the cerebral cortex, the outermost layer of the brain involved with complex cognitive functions such as thought, perception, and memory formation. Cerebral cortex endothelial cells are integral to maintaining brain health and function due to their role in regulating brain microenvironment and controlling the passage of essential molecules and cells.\nThe endothelial cells in the cerebral cortex are distinctive due to their highly selective permeability, largely attributable to the existence of unique tight junctions which maintain the barrier function of the BBB. The tightly interconnected structures of these cells prevent most substances from freely diffusing into the brain tissue, ensuring that harmful agents such as toxins, pathogens, or peripheral immune cells don't reach the brain and compromise its function. These cells also express multiple transporters and enzymes, allowing the selective entry of necessary nutrients and metabolites while excluding toxic substances.\nCerebral cortex endothelial cells also participate in neurovascular coupling, a process where localized neuronal activity increases cerebral blood flow to satisfy the local metabolic demands. The endothelial cells work in coordination with neurons and other cell types such as astrocytes and pericytes to mediate this process. They have been thought to regulate local blood flow by releasing substances in response to neuronal activity. Additionally, these cells are involved in many pathological conditions. Breakdown or dysfunction of the BBB often marked by altered endothelial cell function is linked to numerous neurological disorders including stroke, multiple sclerosis, Alzheimer’s disease, and brain tumors.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1038/nbt.2247", xref="DOI:10.1038/nrn1824", xref="DOI:10.1177/0271678X156179", xref="DOI:10.1186/s12987-020-00230-3", xref="DOI:10.3389/fnins.2023.1047778"} [Term] id: CL:1001603 name: lung macrophage def: "Circulating macrophages and tissue macrophages (alveolar macrophages) of lung." [HPA:HPA, NPX:PDR] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "lung macrophages" RELATED [CALOHA:TS-0576] xref: CALOHA:TS-0576 is_a: CL:0000235 ! macrophage intersection_of: CL:0000235 ! macrophage intersection_of: BFO:0000050 UBERON:0002048 ! part of lung relationship: BFO:0000050 UBERON:0002048 ! part of lung property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_1001603" xsd:string {name="lung macrophage on CELLxGENE CellGuide"} property_value: terms:description "Lung macrophages refer to macrophage populations in the lungs, including the tissue-resident alveolar macrophages and interstitial macrophages, located in the air spaces and the connective tissue of the lung, respectively, and recruited macrophages. They are important in maintaining tissue homeostasis and immunity.\nThe primary function of lung macrophages is to patrol and maintain the pulmonary system, where they serve as the first line of defense against airborne pathogens and inhaled particles. They perform phagocytosis of pathogens, particulate matter, dead cells, and other cellular debris from the lungs to maintain clear air passages and optimize gas exchange. They may also participate in tissue repair and the resolution of inflammation following injury.\nLung macrophages also play a critical role in immune regulation. They help to initiate an immune response by secreting cytokines and other inflammatory mediators and by presenting antigens from the pathogens they have engulfed to induce T cell responses. However, if activated improperly, lung macrophages can contribute to inflammatory diseases of the lung such as chronic obstructive pulmonary disease (COPD) or asthma.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1002/JLB.3RU0720-418R", xref="DOI:10.1016/j.immuni.2022.08.010", xref="DOI:10.1189/jlb.70.2.163", xref="DOI:10.3389/fimmu.2021.753940/full", xref="DOI:10.3390/cells10040897"} [Term] id: CL:1001606 name: foreskin keratinocyte def: "Keratinocyte from foreskin." [NPX:PDR] subset: human_subset subset: mouse_subset xref: CALOHA:TS-0385 is_a: CL:0000312 ! keratinocyte intersection_of: CL:0000312 ! keratinocyte intersection_of: BFO:0000050 UBERON:0001332 ! part of prepuce of penis relationship: BFO:0000050 UBERON:0001332 ! part of prepuce of penis [Term] id: CL:1001607 name: articular chondrocyte def: "Chondrocyte forming the hyaline cartilage found in joints." [NPX:PDR] subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset xref: CALOHA:TS-0056 is_a: CL:0000138 ! chondrocyte intersection_of: CL:0000138 ! chondrocyte intersection_of: BFO:0000050 UBERON:0010996 ! part of articular cartilage of joint relationship: BFO:0000050 UBERON:0010996 ! part of articular cartilage of joint property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:1001608 name: foreskin fibroblast def: "Fibroblast from foreskin." [NPX:PDR] subset: human_subset subset: mouse_subset synonym: "BJ fibroblast" EXACT [] xref: CALOHA:TS-0384 is_a: CL:0002620 ! skin fibroblast intersection_of: CL:0002620 ! skin fibroblast intersection_of: BFO:0000050 UBERON:0001332 ! part of prepuce of penis relationship: BFO:0000050 UBERON:0001332 ! part of prepuce of penis [Term] id: CL:1001609 name: muscle fibroblast def: "Fibroblast from muscle organ." [NPX:PDR] subset: cellxgene_subset subset: human_subset subset: mouse_subset xref: CALOHA:TS-0643 is_a: CL:0000057 ! fibroblast intersection_of: CL:0000057 ! fibroblast intersection_of: BFO:0000050 UBERON:0001630 ! part of muscle organ relationship: BFO:0000050 UBERON:0001630 ! part of muscle organ property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_1001609" xsd:string {name="muscle fibroblast on CELLxGENE CellGuide"} property_value: terms:description "Muscle fibroblasts contribute indispensably to the maintenance, repair, and regeneration processes in the muscles tissue of the body. They are a subtype of fibroblasts, which are generally known as the 'builders' of the animal body's extracellular matrix (ECM) and are crucial players in wound healing. Occupying the connective tissues of muscles, muscle fibroblasts partake in the synthesis of the ECM components, including collagen, fibronectin, and laminin, that give the muscle its structure and flexibility.\nInterestingly, muscle fibroblasts metamorphose functionally during the process of muscle repair following injury. In this circumstance, they react to signals from injured muscle fibers and inflammatory cells, transforming into myofibroblasts. These newly-transformed myofibroblasts showcase contractile properties similar to smooth muscle cells and play a significant role in wound contraction during the healing process while continuing to produce ECM components to ensure reparative scaffolding. Furthermore, muscle fibroblasts secrete various growth factors, primarily those belonging to the 'Transforming Growth Factor-β' (TGF-β) family, to stimulate muscle repair and regulate immune responses.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1002/cbin.10725", xref="DOI:10.1016/j.diff.2016.05.007", xref="DOI:10.1113/JP274403", xref="DOI:10.3389/fimmu.2022.918223", xref="DOI:10.3389/fphys.2020.00253"} [Term] id: CL:1001610 name: bone marrow hematopoietic cell def: "Hematopoietic cells resident in the bone marrow. Include: hematopoietic stem cells (lymphoid stem cells and myeloid stem cells) and the precursor cells for thrombocytes, erythrocytes, basophils, neutrophils, eosinophils, monocytes and lymphocytes." [NPX:PDR] subset: human_subset subset: mouse_subset synonym: "bone marrow hematopoietic cells" RELATED [CALOHA:TS-2109] synonym: "bone marrow poietic cells" RELATED [CALOHA:TS-2109] xref: CALOHA:TS-2109 is_a: CL:0000988 ! hematopoietic cell is_a: CL:0002092 ! bone marrow cell intersection_of: CL:0000988 ! hematopoietic cell intersection_of: BFO:0000050 UBERON:0002371 ! part of bone marrow relationship: BFO:0000050 UBERON:0012429 ! part of hematopoietic tissue property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_1001610" xsd:string {name="bone marrow hematopoietic cell on CELLxGENE CellGuide"} property_value: terms:description "Bone marrow hematopoietic cells are a category of blood-forming stem cells located within the bone marrow, the soft, spongy tissue that fills the cavities of bones. The bone marrow contains specialized environments, referred to as the stem cell niche, to nurture and regulate the development of these cells. These cells are vital for the production and development of new blood cells, functioning as the primary source of cellular regeneration throughout a person's life. They are capable of self-renewal and differentiation into every type of mature blood cell.\nHematopoietic stem cells differentiate into two main lineages: myeloid and lymphoid cells. Myeloid cells can further differentiate into red blood cells, which carry oxygen throughout the body, platelets that contribute to clot formation, and certain types of white blood cells such as neutrophils, eosinophils, basophils, and monocytes. These white blood cells play a crucial role in the innate immune response, helping to fight infection and disease. Lymphoid cells develop into other types of white blood cells: T-cells, B-cells, and innate lymphoid cells, which contribute to the cellular and humoral immune response.\nFurthermore, the bone marrow hematopoietic cells have a unique ability to replace any blood cell in the body that has been destroyed or lost due to illness or injury. Through this regenerative functionality, they are vitally important to the body's defense mechanisms, disease response, and homeostasis. These cells are used in bone marrow transplants and are of interest in regenerative medicine applications.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1016/B978-0-323-04404-2.10002-8", xref="DOI:10.1016/j.semcdb.2020.05.014", xref="DOI:10.1182/blood-2009-11-253534"} [Term] id: CL:1001611 name: cerebellar neuron def: "Neuron of the cerebellum." [NPX:PDR] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "cerebellum neuron" RELATED [CALOHA:TS-2359] xref: CALOHA:TS-2359 xref: FMA:84665 is_a: BFO:0000002 is_a: CL:2000029 ! central nervous system neuron intersection_of: CL:0000540 ! neuron intersection_of: RO:0002100 UBERON:0002037 ! has soma location cerebellum relationship: RO:0002100 UBERON:0002037 ! has soma location cerebellum property_value: skos:prefLabel "cerebellar neuron" xsd:string [Term] id: CL:1100001 name: secretory epithelial cell def: "An epithelial cell that is specialised for the synthesis and secretion of specific biomolecules." [https://orcid.org/0000-0002-7073-9172] subset: human_subset subset: mouse_subset is_a: CL:0000066 ! epithelial cell is_a: CL:0000151 ! secretory cell intersection_of: CL:0000066 ! epithelial cell intersection_of: CL:0000151 ! secretory cell property_value: skos:prefLabel "secretory epithelial cell" xsd:string property_value: terms:contributor https://orcid.org/0000-0002-7073-9172 property_value: terms:date "2024-07-21T09:24:44Z" xsd:dateTime [Term] id: CL:2000000 name: epidermal melanocyte def: "Any melanocyte that is part of a epidermis." [GOC:TermGenie] comment: These cells are found primarily, but not exclusively, in primates including humans subset: human_subset subset: mouse_subset is_a: CL:0002484 ! epithelial melanocyte is_a: CL:1000458 ! melanocyte of skin intersection_of: CL:0000148 ! melanocyte intersection_of: BFO:0000050 UBERON:0001003 ! part of skin epidermis relationship: BFO:0000050 UBERON:0001003 ! part of skin epidermis property_value: terms:contributor http://www.wikidata.org/entity/Q35563349 creation_date: 2014-02-03T23:03:09Z [Term] id: CL:2000001 name: peripheral blood mononuclear cell def: "A leukocyte with a single non-segmented nucleus in the mature form found in the circulatory pool of blood." [GOC:TermGenie] subset: cellxgene_subset subset: human_subset subset: mouse_subset is_a: CL:0000080 ! circulating cell is_a: CL:0000842 ! mononuclear leukocyte intersection_of: CL:0000842 ! mononuclear leukocyte intersection_of: BFO:0000050 UBERON:0000178 ! part of blood relationship: BFO:0000050 UBERON:0000178 ! part of blood property_value: terms:contributor http://www.wikidata.org/entity/Q35563349 creation_date: 2014-02-11T17:29:04Z [Term] id: CL:2000002 name: decidual cell def: "A specialized, enlarged, connective tissue cell of the decidua with enlarged nucleus, dense membrane‐bound secretory granules and cytoplasmic accumulation of glycogen and lipid droplets. These cells develop by the transformation of endometrial stromal cells during decidualization." [BTO:0002770, NCIT:C32429, PMID:30013421, PMID:30429548, Wiki:Decidual_cells&oldid=937509751, Wiki:Decidualization&oldid=908981933] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "decidua cell" EXACT [BTO:0002770, NCIT:C32429] synonym: "decidual stromal cell" EXACT [BTO:0005756, PMID:11719592] synonym: "decidualized endometrial stromal cell" EXACT [PMID:31907034] xref: BTO:0002770 xref: BTO:0005756 xref: NCIT:C32429 is_a: CL:0000349 ! extraembryonic cell is_a: CL:0000499 ! stromal cell relationship: BFO:0000050 UBERON:0002450 ! part of decidua relationship: RO:0002202 CL:0002255 ! develops from stromal cell of endometrium property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_2000002" xsd:string {name="decidual cell on CELLxGENE CellGuide"} property_value: terms:description "Decidual cells, originating from the endometrial lining in the uterus, undergo significant transformations during pregnancy and are integral to its preparation and maintenance. Their conversion from endometrial fibroblast to a secretory phenotype, known as decidualization, occurs as a normal process in the menstrual cycle or in response to embryo implantation.\nWith crucial roles in regulating maternal immune responses and placental development, decidual cells have a twofold function: preventing rejection of the conceptus by the mother's immune system and guiding placental development to avoid excessive trophoblast invasion leading to pre-eclampsia. During decidualization, these cells secrete proteins and growth factors supporting embryo implantation and sustaining early pregnancy. Furthermore, decidual cells modulate the activities of natural killer cells, macrophages, and T cells in the uterus, maintaining a balance of pro-inflammatory and anti-inflammatory conditions during pregnancy.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1002/rmb2.12088", xref="DOI:10.1093/humupd/dmw004", xref="DOI:10.1111/j.1749-6632.2010.05938.x", xref="DOI:10.3390/ijms21114092"} creation_date: 2014-02-20T23:06:41Z [Term] id: CL:2000004 name: pituitary gland cell def: "Any cell that is part of a pituitary gland." [GOC:TermGenie] subset: cellxgene_subset subset: human_subset subset: mouse_subset is_a: CL:0002319 ! neural cell intersection_of: CL:0000000 ! cell intersection_of: BFO:0000050 UBERON:0000007 ! part of pituitary gland relationship: BFO:0000050 UBERON:0000007 ! part of pituitary gland property_value: skos:prefLabel "pituitary gland cell" xsd:string property_value: terms:contributor http://www.wikidata.org/entity/Q35563349 creation_date: 2014-03-26T22:14:56Z [Term] id: CL:2000005 name: brain macroglial cell def: "Any macroglial cell that is part of a brain." [GOC:TermGenie] subset: human_subset subset: mouse_subset is_a: CL:0000126 ! macroglial cell intersection_of: CL:0000126 ! macroglial cell intersection_of: BFO:0000050 UBERON:0000955 ! part of brain relationship: BFO:0000050 UBERON:0000955 ! part of brain property_value: terms:contributor http://www.wikidata.org/entity/Q35563349 creation_date: 2014-03-28T21:35:27Z [Term] id: CL:2000006 name: tonsil germinal center B cell def: "Any germinal center B cell that is part of a tonsil." [GOC:TermGenie] subset: cellxgene_subset subset: human_subset subset: mouse_subset is_a: CL:0000844 ! germinal center B cell intersection_of: CL:0000844 ! germinal center B cell intersection_of: BFO:0000050 UBERON:0002372 ! part of tonsil relationship: BFO:0000050 UBERON:0002372 ! part of tonsil property_value: terms:contributor http://www.wikidata.org/entity/Q35563349 creation_date: 2014-03-28T21:35:33Z [Term] id: CL:2000007 name: articular chondrocyte of knee joint def: "Chondrocyte forming the hyaline cartilage found in the knee joint." [GOC:TermGenie] subset: human_subset subset: mouse_subset is_a: CL:1001607 ! articular chondrocyte intersection_of: CL:1001607 ! articular chondrocyte intersection_of: BFO:0000050 UBERON:0001485 ! part of knee joint relationship: BFO:0000050 UBERON:0001485 ! part of knee joint property_value: terms:contributor http://www.wikidata.org/entity/Q35563349 creation_date: 2014-06-04T14:40:11Z [Term] id: CL:2000008 name: microvascular endothelial cell def: "Any blood vessel endothelial cell that is part of a microvascular endothelium." [GOC:TermGenie] subset: cellxgene_subset subset: human_subset subset: mouse_subset is_a: CL:0000071 ! blood vessel endothelial cell intersection_of: CL:0000071 ! blood vessel endothelial cell intersection_of: BFO:0000050 UBERON:0008339 ! part of microvascular endothelium relationship: BFO:0000050 UBERON:0008339 ! part of microvascular endothelium property_value: terms:contributor http://www.wikidata.org/entity/Q35563349 creation_date: 2014-06-04T15:07:42Z [Term] id: CL:2000009 name: obsolete microvascular endothelium blood vessel endothelial cell def: "Any blood vessel endothelial cell that is part of a microvascular endothelium." [GOC:TermGenie] property_value: terms:contributor http://www.wikidata.org/entity/Q35563349 is_obsolete: true replaced_by: CL:2000008 creation_date: 2014-06-04T15:09:18Z [Term] id: CL:2000010 name: dermis blood vessel endothelial cell def: "Any blood vessel endothelial cell that is part of a dermis." [GOC:TermGenie] subset: human_subset subset: mouse_subset is_a: CL:0000071 ! blood vessel endothelial cell intersection_of: CL:0000071 ! blood vessel endothelial cell intersection_of: BFO:0000050 UBERON:0002067 ! part of dermis relationship: BFO:0000050 UBERON:0002067 ! part of dermis property_value: terms:contributor http://www.wikidata.org/entity/Q35563349 creation_date: 2014-06-04T15:12:06Z [Term] id: CL:2000011 name: dermis lymphatic vessel endothelial cell def: "Any endothelial cell of lymphatic vessel that is part of a dermis." [GOC:TermGenie] subset: human_subset subset: mouse_subset is_a: CL:0002138 ! endothelial cell of lymphatic vessel intersection_of: CL:0002138 ! endothelial cell of lymphatic vessel intersection_of: BFO:0000050 UBERON:0002067 ! part of dermis relationship: BFO:0000050 UBERON:0002067 ! part of dermis property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_2000011" xsd:string {name="dermis lymphatic vessel endothelial cell on CELLxGENE CellGuide"} property_value: terms:contributor http://www.wikidata.org/entity/Q35563349 property_value: terms:description "A dermis lymphatic vessel endothelial cell is a specialized type of cell that lines the interior surface of lymphatic vessels present in the dermal layer of the skin. These cells are organized into a single layer, forming an integral part of the lymphatic system which acts as the body's secondary circulatory system. The primary function of dermis lymphatic vessel endothelial cells is to facilitate the transportation and regulation of the lymph fluid within the dermis. They act as a barrier, contributing to fluid homeostasis, lipid transport, and immune cell trafficking. These cells are uniquely equipped to let fluid and larger molecules, including proteins and immune cells, into the lymphatic vessels from the surrounding interstitial space. This is enabled by the specialized junctions between the endothelial cells and the presence of primary lymphatic valves that prevent the backflow of lymph.\nAnother paramount role of dermis lymphatic vessel endothelial cells is their involvement in immune response. By interacting with white blood cells, especially T-cells and dendritic cells, they can mediate local immune surveillance and contribute to both innate and adaptive immune responses. These cells are also implicated in a variety of pathological conditions, including lymphedema and metastasis in cancer.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1038/s41423-023-01042-9", xref="DOI:10.1038/s41467-019-14127-9", xref="DOI:10.3389/fimmu.2023.1235812", xref="DOI:10.3389/fphys.2020.00509", xref="DOI:10.3389/fphys.2020.577584"} creation_date: 2014-06-04T15:15:08Z [Term] id: CL:2000012 name: fibroblast of pedal digit skin def: "Any skin fibroblast that is part of a pedal digit skin." [GOC:TermGenie] subset: human_subset subset: mouse_subset is_a: CL:0002620 ! skin fibroblast intersection_of: CL:0002620 ! skin fibroblast intersection_of: BFO:0000050 UBERON:0003530 ! part of pedal digit skin relationship: BFO:0000050 UBERON:0003530 ! part of pedal digit skin property_value: terms:contributor http://www.wikidata.org/entity/Q35563349 creation_date: 2014-06-04T15:16:44Z [Term] id: CL:2000013 name: fibroblast of skin of abdomen def: "Any skin fibroblast that is part of a skin of abdomen." [GOC:TermGenie] subset: human_subset subset: mouse_subset is_a: CL:0002620 ! skin fibroblast intersection_of: CL:0002620 ! skin fibroblast intersection_of: BFO:0000050 UBERON:0001416 ! part of skin of abdomen relationship: BFO:0000050 UBERON:0001416 ! part of skin of abdomen property_value: terms:contributor http://www.wikidata.org/entity/Q35563349 creation_date: 2014-06-04T15:18:16Z [Term] id: CL:2000014 name: fibroblast of upper leg skin def: "Any skin fibroblast that is part of a upper leg skin." [GOC:TermGenie] subset: human_subset subset: mouse_subset is_a: CL:0002620 ! skin fibroblast intersection_of: CL:0002620 ! skin fibroblast intersection_of: BFO:0000050 UBERON:0004262 ! part of upper leg skin relationship: BFO:0000050 UBERON:0004262 ! part of upper leg skin property_value: terms:contributor http://www.wikidata.org/entity/Q35563349 creation_date: 2014-06-04T15:19:44Z [Term] id: CL:2000015 name: fibroblast of arm def: "Any skin fibroblast that is part of a arm." [GOC:TermGenie] subset: human_subset subset: mouse_subset is_a: CL:0002620 ! skin fibroblast intersection_of: CL:0002620 ! skin fibroblast intersection_of: BFO:0000050 UBERON:0001460 ! part of arm relationship: BFO:0000050 UBERON:0001460 ! part of arm property_value: terms:contributor http://www.wikidata.org/entity/Q35563349 creation_date: 2014-06-04T15:29:06Z [Term] id: CL:2000016 name: lung microvascular endothelial cell def: "Any lung endothelial cell that is part of a microvascular endothelium." [GOC:TermGenie] subset: cellxgene_subset subset: human_subset subset: mouse_subset is_a: CL:1001567 ! lung endothelial cell is_a: CL:2000008 ! microvascular endothelial cell intersection_of: CL:1001567 ! lung endothelial cell intersection_of: BFO:0000050 UBERON:0008339 ! part of microvascular endothelium property_value: terms:contributor http://www.wikidata.org/entity/Q35563349 creation_date: 2014-06-04T16:00:56Z [Term] id: CL:2000017 name: fibroblast of peridontal ligament def: "Any fibroblast that is part of a periodontal ligament." [GOC:TermGenie] subset: human_subset subset: mouse_subset is_a: CL:0002556 ! fibroblast of periodontium intersection_of: CL:0000057 ! fibroblast intersection_of: BFO:0000050 UBERON:0008266 ! part of periodontal ligament relationship: BFO:0000050 UBERON:0008266 ! part of periodontal ligament property_value: terms:contributor http://www.wikidata.org/entity/Q35563349 creation_date: 2014-06-04T16:50:33Z [Term] id: CL:2000018 name: endothelial cell of coronary artery def: "Any endothelial cell of artery that is part of a coronary artery." [GOC:TermGenie] subset: cellxgene_subset subset: human_subset subset: mouse_subset is_a: CL:0010006 ! cardiac blood vessel endothelial cell is_a: CL:1000413 ! endothelial cell of artery intersection_of: CL:1000413 ! endothelial cell of artery intersection_of: BFO:0000050 UBERON:0001621 ! part of coronary artery relationship: BFO:0000050 UBERON:0001621 ! part of coronary artery property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_2000018" xsd:string {name="endothelial cell of coronary artery on CELLxGENE CellGuide"} property_value: terms:contributor http://www.wikidata.org/entity/Q35563349 property_value: terms:description "Endothelial cells of the coronary artery are specialized cells that line the inner surface of the coronary arteries, which supply oxygen-rich blood to the myocardium (heart muscle). These cells play key roles in vascular biology including the regulation of vascular tone, blood coagulation, leukocyte adhesion, and platelet adhesion. They are also responsible for maintaining the integrity of the vascular wall.\nTo maintain cardiovascular homeostasis, the endothelial cells of the coronary artery produce substances such as endothelin, a powerful vasoconstrictor, and prostacyclin, which has vasodilatory, anti-inflammatory, and anti-thrombotic properties. They also produce nitric oxide, which has a protective role in the vasculature, preventing inflammation, thrombosis, and platelet aggregation, which are major risk factors for atherosclerosis, leading to coronary heart disease. \nDysfunction or impairment of endothelial cell function in coronary arteries is often considered an early prognostic marker in the development of atherosclerosis. With decreased nitric oxide production or availability, the arterial wall becomes more prone to inflammation, thrombosis, and constriction, all of which lead to plaque formation and eventual blockage of the artery.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1055/s-0031-1283220", xref="DOI:10.1097/00041433-200108000-00003", xref="DOI:10.1097/MCA.0000000000000178", xref="DOI:10.1161/01.CIR.0000153339.27064.14"} creation_date: 2014-06-04T17:08:47Z [Term] id: CL:2000019 name: compound eye photoreceptor cell def: "Any photoreceptor cell that is part of a compound eye." [GOC:TermGenie] xref: FBbt:00006009 {sssom:mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"} is_a: CL:0000287 ! eye photoreceptor cell intersection_of: CL:0000210 ! photoreceptor cell intersection_of: BFO:0000050 UBERON:0000018 ! part of compound eye relationship: BFO:0000050 UBERON:0000018 ! part of compound eye property_value: terms:contributor http://www.wikidata.org/entity/Q35563349 creation_date: 2014-06-24T23:16:45Z [Term] id: CL:2000020 name: inner cell mass cell def: "Any native cell that is part of a inner cell mass." [GOC:TermGenie] subset: human_subset subset: mouse_subset is_a: CL:0000255 ! eukaryotic cell intersection_of: CL:0000000 ! cell intersection_of: BFO:0000050 UBERON:0000087 ! part of inner cell mass relationship: BFO:0000050 UBERON:0000087 ! part of inner cell mass property_value: terms:contributor http://www.wikidata.org/entity/Q35563349 creation_date: 2014-06-24T23:16:53Z [Term] id: CL:2000021 name: sebaceous gland cell def: "Any native cell that is part of a sebaceous gland." [GOC:TermGenie] subset: cellxgene_subset subset: human_subset subset: mouse_subset is_a: CL:0000255 ! eukaryotic cell intersection_of: CL:0000000 ! cell intersection_of: BFO:0000050 UBERON:0001821 ! part of sebaceous gland relationship: BFO:0000050 UBERON:0001821 ! part of sebaceous gland property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_2000021" xsd:string {name="sebaceous gland cell on CELLxGENE CellGuide"} property_value: terms:contributor http://www.wikidata.org/entity/Q35563349 property_value: terms:description "Sebaceous gland cells, also known as sebocytes, are small, oil-producing glands present in the skin of mammals. These specialized cells are predominantly located in the dermis, particularly on the face, scalp, and upper body. \nThe primary function of sebaceous gland cells is the production and secretion of sebum, a complex mixture of lipids including triglycerides, wax esters, squalene, and metabolites of fat-soluble vitamins (such as vitamin E), as well as free fatty acids. The production process involves a unique form of programmed cell death called holocrine secretion. In this process, as sebaceous gland cells mature, they progressively accumulate lipid droplets, before ultimately disintegrating and releasing their lipid-rich contents into the gland's ductal system. \nThe sebum generated by these cells serves multiple purposes. It acts as a waterproofing agent, preventing excessive wetting or drying of the skin and averaging skin's water-holding capacity. Sebum also has antimicrobial properties, providing a natural defense barrier against certain bacterial and fungal species. Additionally, it contributes to the skin’s suppleness and prevents it from becoming brittle. An overproduction or imbalance of sebaceous gland cells can lead to common skin disorders, such as acne, seborrhea, or rosacea, illustrating their importance in skin health.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1016/j.jid.2016.10.017", xref="DOI:10.1080/19381980.2017.1375636", xref="DOI:10.4161/derm.1.2.8472", xref="https://doi.org/10.2147/CLEP.S323744", xref="https://www.sciencedirect.com/topics/agricultural-and-biological-sciences/sebum"} creation_date: 2014-06-24T23:17:00Z [Term] id: CL:2000022 name: cardiac septum cell def: "Any native cell that is part of a cardiac septum." [GOC:TermGenie] subset: human_subset subset: mouse_subset is_a: CL:0002494 ! cardiocyte intersection_of: CL:0000000 ! cell intersection_of: BFO:0000050 UBERON:0002099 ! part of cardiac septum relationship: BFO:0000050 UBERON:0002099 ! part of cardiac septum property_value: terms:contributor http://www.wikidata.org/entity/Q35563349 creation_date: 2014-06-24T23:17:07Z [Term] id: CL:2000023 name: spinal cord ventral column interneuron def: "Any interneuron that is part of a spinal cord ventral column." [GOC:TermGenie] subset: human_subset subset: mouse_subset is_a: CL:0005000 ! spinal cord interneuron intersection_of: CL:0000099 ! interneuron intersection_of: RO:0002100 UBERON:0005375 ! has soma location spinal cord ventral column relationship: RO:0002100 UBERON:0005375 ! has soma location spinal cord ventral column property_value: terms:contributor http://www.wikidata.org/entity/Q35563349 creation_date: 2014-06-25T00:23:36Z [Term] id: CL:2000024 name: spinal cord medial motor column neuron def: "Any neuron that is part of a spinal cord medial motor column." [GOC:TermGenie] subset: human_subset subset: mouse_subset is_a: CL:2000029 ! central nervous system neuron intersection_of: CL:0000540 ! neuron intersection_of: RO:0002100 UBERON:0004059 ! has soma location spinal cord medial motor column relationship: RO:0002100 UBERON:0004059 ! has soma location spinal cord medial motor column property_value: terms:contributor http://www.wikidata.org/entity/Q35563349 creation_date: 2014-06-25T00:23:43Z [Term] id: CL:2000025 name: spinal cord oligodendrocyte def: "Any oligodendrocyte that is part of a spinal cord." [GOC:TermGenie] subset: human_subset subset: mouse_subset is_a: CL:0000128 ! oligodendrocyte intersection_of: CL:0000128 ! oligodendrocyte intersection_of: BFO:0000050 UBERON:0002240 ! part of spinal cord relationship: BFO:0000050 UBERON:0002240 ! part of spinal cord property_value: terms:contributor http://www.wikidata.org/entity/Q35563349 creation_date: 2014-06-25T00:23:50Z [Term] id: CL:2000026 name: obsolete cerebellum Golgi cell def: "Any Golgi cell that is part of a cerebellum." [GOC:TermGenie] property_value: terms:contributor http://www.wikidata.org/entity/Q35563349 is_obsolete: true creation_date: 2014-06-25T00:23:57Z [Term] id: CL:2000027 name: cerebellar basket cell def: "A GABAergic inhibitory interneuron located in the molecular layer of the cerebellar cortex. It projects axons that form specialized synaptic structures around Purkinje cells, including pericellular baskets, which wrap around the Purkinje cell soma, and the pinceau: a brush-like terminal that contacts the initial segment of the Purkinje cell axon. The basket cell modulates Purkinje cell activity through both chemical (GABAergic) and non-synaptic (ephaptic) mechanisms. It is arranged in sagittal rows that align with Purkinje cell zones, contributing to the cerebellum's modular and topographically organized architecture. It plays an essential role in regulating motor coordination and potentially cognitive functions." [PMID:32990595, PMID:8915580] subset: human_subset subset: mouse_subset synonym: "cerebellum basket cell" EXACT [] is_a: CL:0000118 ! basket cell is_a: CL:4042035 ! molecular layer interneuron intersection_of: CL:0000118 ! basket cell intersection_of: RO:0002100 UBERON:0002037 ! has soma location cerebellum property_value: foaf:depiction Candelabrum:cell.png {dc:license="https://creativecommons.org/licenses/by-nc-nd/4.0/", xref="doi:10.3389/fnins.2020.00293"} property_value: foaf:depiction http://purl.obolibrary.org/obo/cl/images/CB_circuits_PMID3650468_f2.png {dc:license="https://creativecommons.org/licenses/by-nc-nd/4.0/", xref="doi:10.1016/j.cnp.2022.11.002"} property_value: terms:contributor http://www.wikidata.org/entity/Q35563349 creation_date: 2014-06-25T00:24:03Z [Term] id: CL:2000028 name: cerebellum glutamatergic neuron def: "Any glutamatergic neuron that is part of a cerebellum." [GOC:TermGenie] subset: cellxgene_subset subset: human_subset subset: mouse_subset is_a: CL:0000679 ! glutamatergic neuron is_a: CL:1001611 ! cerebellar neuron intersection_of: CL:0000679 ! glutamatergic neuron intersection_of: RO:0002100 UBERON:0002037 ! has soma location cerebellum property_value: skos:prefLabel "cerebellum glutamatergic neuron" xsd:string property_value: terms:contributor http://www.wikidata.org/entity/Q35563349 creation_date: 2014-06-25T00:24:10Z [Term] id: CL:2000029 name: central nervous system neuron def: "Any neuron that is part of a central nervous system." [GOC:TermGenie] subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset is_a: CL:0000540 ! neuron intersection_of: CL:0000540 ! neuron intersection_of: RO:0002100 UBERON:0001017 ! has soma location central nervous system relationship: RO:0002100 UBERON:0001017 ! has soma location central nervous system property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "central nervous system neuron" xsd:string property_value: terms:contributor http://www.wikidata.org/entity/Q35563349 creation_date: 2014-06-25T01:17:43Z [Term] id: CL:2000030 name: hypothalamus cell def: "Any native cell that is part of a hypothalamus." [GOC:TermGenie] subset: cellxgene_subset subset: human_subset subset: mouse_subset is_a: CL:0002319 ! neural cell intersection_of: CL:0000000 ! cell intersection_of: BFO:0000050 UBERON:0001898 ! part of hypothalamus relationship: BFO:0000050 UBERON:0001898 ! part of hypothalamus property_value: terms:contributor http://www.wikidata.org/entity/Q35563349 creation_date: 2014-06-25T01:17:50Z [Term] id: CL:2000031 name: lateral line ganglion neuron def: "Any neuron that is part of a lateral line ganglion." [GOC:TermGenie] is_a: BFO:0000002 is_a: CL:2000032 ! peripheral nervous system neuron intersection_of: CL:2000032 ! peripheral nervous system neuron intersection_of: RO:0002100 UBERON:2000120 ! has soma location lateral line ganglion relationship: RO:0002100 UBERON:2000120 ! has soma location lateral line ganglion relationship: RO:0002162 NCBITaxon:32443 ! in taxon Teleostei property_value: terms:contributor http://www.wikidata.org/entity/Q35563349 creation_date: 2014-06-25T01:17:57Z [Term] id: CL:2000032 name: peripheral nervous system neuron alt_id: CL:0000111 def: "A neuron that is part of a peripheral nervous system." [GOC:TermGenie, ISBN:0721662544] subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "peripheral neuron" EXACT [] synonym: "PNS neuron" EXACT [] xref: FMA:84664 is_a: CL:0000540 ! neuron intersection_of: CL:0000540 ! neuron intersection_of: RO:0002100 UBERON:0000010 ! has soma location peripheral nervous system relationship: RO:0002100 UBERON:0000010 ! has soma location peripheral nervous system property_value: RO:0002175 NCBITaxon:9606 property_value: terms:contributor http://www.wikidata.org/entity/Q35563349 creation_date: 2014-06-25T02:28:17Z [Term] id: CL:2000033 name: limb basal cell of epidermis def: "Any basal cell of epidermis that is part of a limb." [GOC:TermGenie] subset: human_subset subset: mouse_subset is_a: CL:0002187 ! basal cell of epidermis intersection_of: CL:0002187 ! basal cell of epidermis intersection_of: BFO:0000050 UBERON:0002101 ! part of limb relationship: BFO:0000050 UBERON:0002101 ! part of limb property_value: terms:contributor http://www.wikidata.org/entity/Q35563349 creation_date: 2014-06-25T02:28:25Z [Term] id: CL:2000034 name: anterior lateral line neuromast hair cell def: "Any neuromast hair cell that is part of a anterior lateral line." [GOC:TermGenie] is_a: CL:0000856 ! neuromast hair cell intersection_of: CL:0000856 ! neuromast hair cell intersection_of: BFO:0000050 UBERON:2001470 ! part of anterior lateral line relationship: BFO:0000050 UBERON:2001470 ! part of anterior lateral line property_value: terms:contributor http://www.wikidata.org/entity/Q35563349 creation_date: 2014-06-25T03:44:37Z [Term] id: CL:2000035 name: anterior lateral line neuromast mantle cell def: "Any neuromast mantle cell that is part of an anterior lateral line." [GOC:TermGenie] is_a: CL:0000851 ! neuromast mantle cell intersection_of: CL:0000851 ! neuromast mantle cell intersection_of: BFO:0000050 UBERON:2001470 ! part of anterior lateral line relationship: BFO:0000050 UBERON:2001470 ! part of anterior lateral line property_value: terms:contributor http://www.wikidata.org/entity/Q35563349 creation_date: 2014-06-25T03:44:44Z [Term] id: CL:2000036 name: anterior lateral line neuromast supporting cell def: "Any neuromast support cell that is part of a anterior lateral line." [GOC:TermGenie] synonym: "anterior lateral line neuromast support cell" EXACT [] is_a: CL:0000852 ! neuromast supporting cell intersection_of: CL:0000852 ! neuromast supporting cell intersection_of: BFO:0000050 UBERON:2001470 ! part of anterior lateral line relationship: BFO:0000050 UBERON:2001470 ! part of anterior lateral line property_value: terms:contributor http://www.wikidata.org/entity/Q35563349 creation_date: 2014-06-25T03:44:51Z [Term] id: CL:2000037 name: posterior lateral line neuromast hair cell def: "Any neuromast hair cell that is part of a posterior lateral line." [GOC:TermGenie] is_a: CL:0000856 ! neuromast hair cell intersection_of: CL:0000856 ! neuromast hair cell intersection_of: BFO:0000050 UBERON:0006334 ! part of posterior lateral line relationship: BFO:0000050 UBERON:0006334 ! part of posterior lateral line property_value: terms:contributor http://www.wikidata.org/entity/Q35563349 creation_date: 2014-06-25T03:44:57Z [Term] id: CL:2000038 name: posterior lateral line neuromast mantle cell def: "Any neuromast mantle cell that is part of a posterior lateral line." [GOC:TermGenie] is_a: CL:0000851 ! neuromast mantle cell intersection_of: CL:0000851 ! neuromast mantle cell intersection_of: BFO:0000050 UBERON:0006334 ! part of posterior lateral line relationship: BFO:0000050 UBERON:0006334 ! part of posterior lateral line property_value: terms:contributor http://www.wikidata.org/entity/Q35563349 creation_date: 2014-06-25T03:45:04Z [Term] id: CL:2000039 name: posterior lateral line neuromast supporting cell def: "Any neuromast support cell that is part of a posterior lateral line." [GOC:TermGenie] synonym: "posterior lateral line neuromast support cell" EXACT [] is_a: CL:0000852 ! neuromast supporting cell intersection_of: CL:0000852 ! neuromast supporting cell intersection_of: BFO:0000050 UBERON:0006334 ! part of posterior lateral line relationship: BFO:0000050 UBERON:0006334 ! part of posterior lateral line property_value: terms:contributor http://www.wikidata.org/entity/Q35563349 creation_date: 2014-06-25T03:45:11Z [Term] id: CL:2000040 name: bladder microvascular endothelial cell def: "Any microvascular endothelial cell that is part of a urinary bladder." [GOC:TermGenie] subset: human_reference_atlas subset: human_subset subset: mouse_subset is_a: CL:1001319 ! bladder cell is_a: CL:2000008 ! microvascular endothelial cell intersection_of: CL:2000008 ! microvascular endothelial cell intersection_of: BFO:0000050 UBERON:0001255 ! part of urinary bladder property_value: RO:0002175 NCBITaxon:9606 property_value: terms:contributor http://www.wikidata.org/entity/Q35563349 creation_date: 2014-07-09T00:04:47Z [Term] id: CL:2000041 name: dermis microvascular lymphatic vessel endothelial cell def: "Any dermis lymphatic vessel endothelial cell that is part of a microvascular endothelium." [GOC:TermGenie] subset: cellxgene_subset subset: human_subset subset: mouse_subset is_a: CL:0011030 ! dermal microvascular endothelial cell is_a: CL:2000011 ! dermis lymphatic vessel endothelial cell intersection_of: CL:2000011 ! dermis lymphatic vessel endothelial cell intersection_of: BFO:0000050 UBERON:0008339 ! part of microvascular endothelium property_value: terms:contributor http://www.wikidata.org/entity/Q35563349 creation_date: 2014-07-09T00:09:54Z [Term] id: CL:2000042 name: embryonic fibroblast def: "Any fibroblast that is part of a embryo." [GOC:TermGenie] subset: cellxgene_subset subset: human_subset subset: mouse_subset is_a: CL:0000057 ! fibroblast intersection_of: CL:0000057 ! fibroblast intersection_of: BFO:0000050 UBERON:0000922 ! part of embryo relationship: BFO:0000050 UBERON:0000922 ! part of embryo property_value: terms:contributor http://www.wikidata.org/entity/Q35563349 creation_date: 2014-07-09T00:12:00Z [Term] id: CL:2000043 name: brain pericyte def: "Any pericyte cell that is part of a brain." [GOC:TermGenie] subset: cellxgene_subset subset: human_subset subset: mouse_subset is_a: CL:0002575 ! central nervous system pericyte intersection_of: CL:0000669 ! pericyte intersection_of: BFO:0000050 UBERON:0000955 ! part of brain relationship: BFO:0000050 UBERON:0000955 ! part of brain property_value: terms:contributor http://www.wikidata.org/entity/Q35563349 creation_date: 2014-07-09T00:18:22Z [Term] id: CL:2000044 name: brain microvascular endothelial cell def: "Any microvascular endothelial cell that is part of a brain." [GOC:TermGenie] subset: human_subset subset: mouse_subset is_a: CL:0002319 ! neural cell is_a: CL:2000008 ! microvascular endothelial cell intersection_of: CL:2000008 ! microvascular endothelial cell intersection_of: BFO:0000050 UBERON:0000955 ! part of brain relationship: BFO:0000050 UBERON:0000955 ! part of brain property_value: terms:contributor http://www.wikidata.org/entity/Q35563349 creation_date: 2014-07-09T00:24:53Z [Term] id: CL:2000045 name: foreskin melanocyte def: "Any melanocyte of skin that is part of a skin of prepuce of penis." [GOC:TermGenie] subset: human_subset subset: mouse_subset synonym: "melanocyte of foreskin" EXACT [] is_a: CL:1000458 ! melanocyte of skin intersection_of: CL:1000458 ! melanocyte of skin intersection_of: BFO:0000050 UBERON:0001471 ! part of skin of prepuce of penis relationship: BFO:0000050 UBERON:0001471 ! part of skin of prepuce of penis property_value: terms:contributor http://www.wikidata.org/entity/Q35563349 property_value: terms:contributor https://orcid.org/0009-0000-8480-9277 creation_date: 2014-07-09T00:45:07Z [Term] id: CL:2000046 name: ventricular cardiac muscle cell def: "Any cardiac muscle cell that is part of a cardiac ventricle." [GOC:TermGenie] subset: cellxgene_subset subset: human_subset subset: mouse_subset is_a: CL:0000746 ! cardiac muscle cell intersection_of: CL:0000746 ! cardiac muscle cell intersection_of: BFO:0000050 UBERON:0002082 ! part of cardiac ventricle relationship: BFO:0000050 UBERON:0002082 ! part of cardiac ventricle property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_2000046" xsd:string {name="ventricular cardiac muscle cell on CELLxGENE CellGuide"} property_value: terms:contributor http://www.wikidata.org/entity/Q35563349 property_value: terms:description "Ventricular cardiac muscle cells, or cardiomyocytes, are specialized cells found in the ventricular walls of the heart. They exhibit unique features, including centrally located nuclei, robust cytoskeletal structures, high mitochondria content, and intercalated discs, which contribute to their efficient pumping of blood throughout the body. \nThe main role of ventricular cardiac muscle cells is to coordinate contractions, enabling the heart to pump blood throughout the body. This is achieved through controlled ion movement across cell membranes, generating rhythmic electrical signals called action potentials. Intercalated discs between these cells aid synchronized contractions by allowing efficient signal spread through gap junctions. The high mitochondrial content ensures a constant energy supply for this ongoing contraction cycle.\nVentricular cardiac muscle cells contribute not only mechanically but also biochemically by secreting essential hormones like atrial natriuretic peptide and B-type natriuretic peptide for blood pressure regulation and cardiac remodeling. These cells exhibit low turnover under normal conditions, emphasizing their long-term stability, yet have limited regenerative capacity following cardiac injuries. Dysfunction in these cells can result in significant cardiac issues, including heart failure.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1016/j.peptides.2018.05.012", xref="DOI:10.1126/science.aam5894", xref="https://www.ncbi.nlm.nih.gov/books/NBK535355", xref="https://www.ncbi.nlm.nih.gov/books/NBK572070/"} creation_date: 2014-08-12T20:50:28Z [Term] id: CL:2000047 name: brainstem motor neuron def: "Any motor neuron that is part of a brainstem." [GOC:TermGenie] subset: cellxgene_subset subset: human_subset subset: mouse_subset is_a: BFO:0000002 is_a: CL:0000100 ! motor neuron is_a: CL:2000029 ! central nervous system neuron intersection_of: CL:0000100 ! motor neuron intersection_of: RO:0002100 UBERON:0002298 ! has soma location brainstem relationship: RO:0002100 UBERON:0002298 ! has soma location brainstem property_value: terms:contributor http://www.wikidata.org/entity/Q35563349 creation_date: 2014-10-02T23:52:53Z [Term] id: CL:2000048 name: anterior horn motor neuron def: "A lower motor neuron whose soma is located in the anterior horn. Anterior horn motor neurons project from the anterior portion of the grey matter in the spinal cord to some skeletal muscles." [DOI:10.1016/B978-0-12-817962-8.00025-1] comment: Yang & Connolly (DOI:10.1016/B978-0-323-37101-8.00140-5) classify these as alpha motor neurons. Consider reflecting this if more references support this. subset: human_subset subset: mouse_subset synonym: "anterior horn cell" EXACT [] synonym: "ventral horn of spinal cord spinal cord motor neuron" EXACT [] xref: NCIT:C12645 is_a: CL:0002612 ! neuron of the ventral spinal cord is_a: CL:0008039 ! lower motor neuron is_a: CL:0011001 ! spinal cord motor neuron property_value: terms:contributor http://www.wikidata.org/entity/Q35563349 creation_date: 2014-10-03T00:26:27Z [Term] id: CL:2000049 name: primary motor cortex pyramidal cell def: "Any pyramidal cell that is part of a primary motor cortex." [GOC:TermGenie] comment: http://www.ncbi.nlm.nih.gov/pubmed/12524689 subset: human_subset subset: mouse_subset is_a: CL:4023111 ! cerebral cortex pyramidal neuron intersection_of: CL:0000598 ! pyramidal neuron intersection_of: RO:0002100 UBERON:0001384 ! has soma location primary motor cortex relationship: RO:0002100 UBERON:0001384 ! has soma location primary motor cortex property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_2000049" xsd:string {name="primary motor cortex pyramidal cell on CELLxGENE CellGuide"} property_value: terms:contributor http://www.wikidata.org/entity/Q35563349 property_value: terms:description "Primary motor cortex pyramidal cells (PMCPs) are a specific type of neuron found predominantly in the primary motor cortex of the brain, which holds a vital role in controlling voluntary movements. These cells are characterized by their distinct pyramidal - triangularly - shaped cell bodies, large size, and long branching dendrites that facilitate extensive interneuronal connectivity. PMCPs, along with other cortical pyramidal cells, are excitatory neurons, meaning they carry electrical impulses away from the cell body, facilitating communication between different areas of the brain and the spinal cord.\nThe principal function of PMCPs revolves around motor control. PMCPs in the primary motor cortex are responsible for mapping and planning complex movements, from the intention to move to the actual execution. For example, Betz cells are a type of PMCPs that extend their long axons, collectively known as the Corticospinal Tract (CST), which descends from the cortex to the spinal cord, synapsing with neurons in the spinal cord that control muscles throughout the body. This information transmission allows PMCPs to control precise, skillful, and independent movements of both proximal and distal muscles.\nAside from controlling voluntary movement, PMCPs contribute to motor learning and adaptation by establishing new neuronal connections and strengthening existing ones. Studies using techniques like optogenetics and two-photon imaging have revealed that PMCPs undergo significant synaptic plasticity during motor learning, indicating their role in modifying motor outputs in response to training and experience. Overall, PMCPs provide a biochemical and anatomic basis for translating thoughts into actions, an essential process for the organism's interaction with the environment.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1038/s41586-021-03950-0", xref="DOI:10.1046/j.1469-7580.2001.19960699.x", xref="DOI:10.1093/cercor/bhw134", xref="https://www.ncbi.nlm.nih.gov/books/NBK540976"} creation_date: 2014-10-06T17:39:04Z [Term] id: CL:2000050 name: obsolete retina retinal ganglion cell def: "Any retinal ganglion cell that is part of a retina." [GOC:TermGenie] comment: http://www.ncbi.nlm.nih.gov/pubmed/2889210 property_value: terms:contributor http://www.wikidata.org/entity/Q35563349 is_obsolete: true creation_date: 2014-10-06T17:43:59Z [Term] id: CL:2000051 name: splenic fibroblast def: "Any fibroblast that is part of a spleen." [GOC:TermGenie] subset: human_subset subset: mouse_subset is_a: CL:0000057 ! fibroblast intersection_of: CL:0000057 ! fibroblast intersection_of: BFO:0000050 UBERON:0002106 ! part of spleen relationship: BFO:0000050 UBERON:0002106 ! part of spleen property_value: terms:contributor http://www.wikidata.org/entity/Q35563349 creation_date: 2014-10-06T18:58:47Z [Term] id: CL:2000052 name: umbilical artery endothelial cell def: "Any endothelial cell of artery that is part of a umbilical cord." [GOC:TermGenie] comment: http://www.sciencellonline.com/site/productInformation.php?keyword=8010 subset: human_subset subset: mouse_subset is_a: CL:0000349 ! extraembryonic cell is_a: CL:1000413 ! endothelial cell of artery intersection_of: CL:1000413 ! endothelial cell of artery intersection_of: BFO:0000050 UBERON:0002331 ! part of umbilical cord relationship: BFO:0000050 UBERON:0002331 ! part of umbilical cord property_value: terms:contributor http://www.wikidata.org/entity/Q35563349 creation_date: 2014-10-06T19:01:48Z [Term] id: CL:2000053 name: splenic endothelial cell def: "Any endothelial cell that is part of a spleen." [GOC:TermGenie] comment: http://www.sciencellonline.com/site/productInformation.php?keyword=5500 subset: human_reference_atlas subset: human_subset subset: mouse_subset is_a: CL:0000115 ! endothelial cell intersection_of: CL:0000115 ! endothelial cell intersection_of: BFO:0000050 UBERON:0002106 ! part of spleen relationship: BFO:0000050 UBERON:0002106 ! part of spleen property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/2d-ftu/spleen-white-pulp/v1.2/assets/2d-ftu-spleen-white-pulp.png" xsd:string {terms:licence="http://creativecommons.org/licenses/by/4.0/", xref="doi:10.48539/HBM559.FNBB.6273"} property_value: RO:0002175 NCBITaxon:9606 property_value: terms:contributor http://www.wikidata.org/entity/Q35563349 creation_date: 2014-10-06T19:06:04Z [Term] id: CL:2000054 name: hepatic pit cell def: "A large, granular, liver specific natural killer cell that adheres to the endothelial cells of the hepatic sinusoid." [GOC:dos, PMID:9408963] comment: Pit cells are named for the presence of large cytoplasmic granules that resemble pits (pips) of fruit. subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset is_a: CL:4047101 ! liver-resident natural killer cell property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:2000055 name: liver dendritic cell def: "Any dendritic cell that is part of a liver." [GOC:TermGenie] comment: http://www.jleukbio.org/content/66/2/322.abstract subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "hepatic dendritic cell" EXACT [] is_a: CL:0000451 ! dendritic cell intersection_of: CL:0000451 ! dendritic cell intersection_of: BFO:0000050 UBERON:0002107 ! part of liver relationship: BFO:0000050 UBERON:0002107 ! part of liver property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_2000055" xsd:string {name="liver dendritic cell on CELLxGENE CellGuide"} property_value: terms:contributor http://www.wikidata.org/entity/Q35563349 property_value: terms:description "Liver dendritic cells (DCs) refer to all dendritic cells found in the liver. Liver DCs, much like other DCs, play a critical role in initiating and directing immune responses. However, they show unique characteristics and functions due to their location in the liver, an organ with an important role in metabolism and immunity.\nThe liver contains both conventional or classical and plasmacytoid DCs. Liver DCs generally have an immature phenotype and are thought to aid in the maintenance of hepatic tolerance. The liver is constantly exposed to dietary and gut-derived antigens, which requires the liver to strike a balance to avoid excessive immune response against these substances. Liver dendritic cells play an essential role in this balance through various mechanisms, such as promoting the development of regulatory T cells. In some cases, liver DCs have also been demonstrated to exhibit stimulatory activity.\nLiver DCs play an important role in liver transplantation outcomes and hepatic diseases including viral infections, carcinomas, and primary biliary cirrhosis.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1002/hep.21974", xref="DOI:10.1016/bs.ircmb.2019.07.004", xref="DOI:10.1016/j.bbadis.2013.01.005", xref="DOI:10.1046/j.0818-9641.2001.01058.x", xref="DOI:10.1136/gut.52.2.307"} creation_date: 2014-10-06T19:16:11Z [Term] id: CL:2000056 name: Meynert cell def: "Any pyramidal cell that is part of a regional part of cerebral cortex." [GOC:TermGenie] subset: human_subset subset: mouse_subset is_a: CL:2000049 ! primary motor cortex pyramidal cell property_value: terms:contributor http://www.wikidata.org/entity/Q35563349 creation_date: 2014-10-06T19:20:41Z [Term] id: CL:2000057 name: femoral osteoblast def: "Any osteoblast that is part of a femur." [GOC:TermGenie, PMID:34565180, PMID:34569806] subset: human_subset subset: mouse_subset is_a: CL:0000062 ! osteoblast is_a: CL:0001035 ! bone cell intersection_of: CL:0000062 ! osteoblast intersection_of: BFO:0000050 UBERON:0000981 ! part of femur relationship: BFO:0000050 UBERON:0000981 ! part of femur property_value: terms:contributor http://www.wikidata.org/entity/Q35563349 creation_date: 2014-10-06T19:29:45Z [Term] id: CL:2000058 name: calvarial osteoblast def: "Any osteoblast that is part of a skull." [GOC:TermGenie] comment: http://www.sciencellonline.com/site/productInformation.php?keyword=4600 subset: human_subset subset: mouse_subset is_a: CL:0000062 ! osteoblast intersection_of: CL:0000062 ! osteoblast intersection_of: BFO:0000050 UBERON:0003129 ! part of skull relationship: BFO:0000050 UBERON:0003129 ! part of skull property_value: terms:contributor http://www.wikidata.org/entity/Q35563349 creation_date: 2014-10-06T19:48:30Z [Term] id: CL:2000059 name: prostate gland microvascular endothelial cell def: "Any microvascular endothelial cell that is part of a prostate gland." [GOC:TermGenie] comment: http://www.sciencellonline.com/site/productInformation.php?keyword=4400 subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset is_a: CL:2000008 ! microvascular endothelial cell intersection_of: CL:2000008 ! microvascular endothelial cell intersection_of: BFO:0000050 UBERON:0002367 ! part of prostate gland relationship: BFO:0000050 UBERON:0002367 ! part of prostate gland property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/2d-ftu/prostate-prostate-glandular-acinus/v1.2/assets/2d-ftu-prostate-prostate-glandular-acinus.png" xsd:string {terms:licence="http://creativecommons.org/licenses/by/4.0/", xref="doi:10.48539/HBM347.TXWZ.899"} property_value: RO:0002175 NCBITaxon:9606 property_value: terms:contributor http://www.wikidata.org/entity/Q35563349 creation_date: 2014-10-07T17:46:27Z [Term] id: CL:2000060 name: placental villous trophoblast def: "A trophoblast of placental villi. These cells fuse to form synctial trophoplast - the placental side of the interface between the placenta and maternal blood sinusoids in the decidua." [PMID:31049600] comment: Same as synctial trophoblast? subset: cellxgene_subset subset: mouse_subset synonym: "vCTB" EXACT [PMID:31049600] synonym: "villous cytotrophoblast" EXACT [] xref: BTO:0006119 xref: BTO:0006208 is_a: CL:0000351 ! trophoblast cell intersection_of: CL:0000351 ! trophoblast cell intersection_of: BFO:0000050 UBERON:0010005 ! part of placental labyrinth villous relationship: BFO:0000050 UBERON:0010005 ! part of placental labyrinth villous property_value: seeAlso "http://www.sciencellonline.com/site/productInformation.php?keyword=7120" xsd:string property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_2000060" xsd:string {name="placental villous trophoblast on CELLxGENE CellGuide"} property_value: terms:contributor http://www.wikidata.org/entity/Q35563349 property_value: terms:description "The placental villous trophoblast, a highly specialized cell type crucial for placental development, plays a key role in facilitating exchanges between the maternal bloodstream and the developing fetus.\nStructurally, placental villous trophoblasts are situated on the villous tree structures, forming an outer epithelial layer. Comprising two subtypes—proliferating cytotrophoblasts forming the inner layer and terminally differentiated syncytiotrophoblasts constituting the outer layer in contact with maternal blood—these cells define the placental architecture.\nFunctionally, placental villous trophoblasts play pivotal roles in forming and maintaining the placenta, ensuring the safe development of the fetus. Their primary function involves managing substance exchange between the mother and fetus, mediating the transfer of gases, nutrients, hormones, and waste materials to support optimal fetal growth. Additionally, these trophoblasts synthesize and release crucial hormones like human chorionic gonadotropin (hCG), which maintains the decidua and signals the mother's body to sustain pregnancy. Acting as a physical and immunological barrier, they protect the fetus from maternal immune cells and prevent the transmission of pathogens, contributing significantly to the success of pregnancy.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1007/s00018-019-03104-6", xref="DOI:10.3389/fimmu.2020.00343", xref="DOI:10.3390/nu15163564"} creation_date: 2014-10-07T17:48:27Z [Term] id: CL:2000061 name: placental amniotic mesenchymal stromal cell def: "Any mesenchymal stem cell that is part of a placenta." [GOC:TermGenie] comment: http://www.sciencellonline.com/site/productInformation.php?keyword=7140 subset: human_reference_atlas subset: human_subset subset: mouse_subset is_a: CL:0000134 ! mesenchymal stem cell intersection_of: CL:0000134 ! mesenchymal stem cell intersection_of: BFO:0000050 UBERON:0001987 ! part of placenta relationship: BFO:0000050 UBERON:0001987 ! part of placenta property_value: RO:0002175 NCBITaxon:9606 property_value: terms:contributor http://www.wikidata.org/entity/Q35563349 creation_date: 2014-10-07T17:51:11Z [Term] id: CL:2000062 name: placental villus capillary endothelial cell def: "Any capillary endothelial cell that is part of a placenta." [GOC:TermGenie] comment: http://www.ncbi.nlm.nih.gov/books/NBK53245/ subset: human_reference_atlas subset: human_subset subset: mouse_subset is_a: CL:0002144 ! capillary endothelial cell is_a: CL:0009092 ! endothelial cell of placenta intersection_of: CL:0002144 ! capillary endothelial cell intersection_of: BFO:0000050 UBERON:0001987 ! part of placenta property_value: RO:0002175 NCBITaxon:9606 property_value: terms:contributor http://www.wikidata.org/entity/Q35563349 creation_date: 2014-10-07T17:55:56Z [Term] id: CL:2000063 name: ovarian fibroblast def: "Any fibroblast that is part of a female gonad." [GOC:TermGenie] comment: http://www.sciencellonline.com/site/productInformation.php?keyword=7330 subset: human_subset subset: mouse_subset is_a: CL:0000057 ! fibroblast is_a: CL:0002132 ! stromal cell of ovary intersection_of: CL:0000057 ! fibroblast intersection_of: BFO:0000050 UBERON:0000992 ! part of ovary property_value: terms:contributor http://www.wikidata.org/entity/Q35563349 creation_date: 2014-10-07T17:57:42Z [Term] id: CL:2000064 name: ovarian surface epithelial cell def: "A meso-epithelial cell of the ovarian surface epithelium, varying in shape from flat to cuboidal to pseudostratified columnar. This cell plays a crucial role in ovulation by producing proteolytic enzymes in response to gonadotropins, facilitating follicle rupture through tissue breakdown and TNF-alpha signaling. Additionally, this cell contributes to post-ovulatory wound repair (Morris et al., 2022) and exhibits stem cell-like properties (Flesken-Nikitin et al., 2013; Wang et al., 2019)." [GOC:TermGenie, PMID:12052228, PMID:15749958, PMID:23467088, PMID:31672973, PMID:36205477] subset: cellxgene_subset subset: human_subset subset: mouse_subset is_a: CL:0002078 ! meso-epithelial cell intersection_of: CL:0002078 ! meso-epithelial cell intersection_of: BFO:0000050 UBERON:0001304 ! part of germinal epithelium of ovary relationship: BFO:0000050 UBERON:0001304 ! part of germinal epithelium of ovary property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_2000064" xsd:string {name="ovarian surface epithelial cell on CELLxGENE CellGuide"} property_value: terms:contributor http://www.wikidata.org/entity/Q35563349 property_value: terms:description "Ovarian surface epithelial (OSE) cells form the ovarian epithelium, a single layer of cells that covers the external surface of the ovaries, continuous with the peritoneal mesothelium. The epithelium varies morphologically from cuboidal, to simple flattened, and low pseudostratified columnar cells, depending on the cyclic changes in the underlying ovarian structure. \nThe epithelial layer functions as a physical barrier that protects the ovarian stem cells and the follicular cells from mechanical stress and potential foreign pathogens, and they provide a supportive tissue microenvironment for the underlying cells of the ovaries. The OSE is separated from the ovarian stroma by a basement membrane, to which it is only loosely attached. \nOSE cells play a crucial role in ovarian physiology and pathology. They are involved in processes associated with ovarian follicular growth, maturation, ovulation and follicular atresia. Moreover, they have a prominent role in repairing the ovarian surface following the rupture of the follicle during ovulation, essentially playing a key part in the regenerative processes post-ovulation. Shedding and regeneration of OSE cells is a dynamic process that repeats throughout each reproductive cycle.\nOSE cells are also the primary origin of ovarian cancer, specifically, epithelial ovarian cancer which accounts for about 90% of all ovarian cancers. The constant rounds of rapid proliferation and repair following ovulation are thought to provide the opportunity for replication errors and hence contribute to neoplastic changes in the OSE.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1073/pnas.0805012105", xref="DOI:10.1210/edrv.22.2.0422", xref="DOI:10.1677/JME-07-0149", xref="DOI:10.3389/fendo.2022.886533"} creation_date: 2014-10-07T17:59:13Z [Term] id: CL:2000065 name: ovarian microvascular endothelial cell def: "Any microvascular endothelial cell that is part of a female urethra." [GOC:TermGenie] comment: http://www.sciencellonline.com/site/productInformation.php?keyword=7300 subset: human_subset subset: mouse_subset is_a: CL:1001320 ! urethra cell is_a: CL:2000008 ! microvascular endothelial cell intersection_of: CL:2000008 ! microvascular endothelial cell intersection_of: BFO:0000050 UBERON:0001334 ! part of female urethra relationship: BFO:0000050 UBERON:0001334 ! part of female urethra property_value: terms:contributor http://www.wikidata.org/entity/Q35563349 creation_date: 2014-10-07T18:18:01Z [Term] id: CL:2000066 name: cardiac ventricle fibroblast def: "Any fibroblast that is part of a cardiac ventricle." [GOC:TermGenie] comment: http://www.sciencellonline.com/site/productInformation.php?keyword=6310 subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset is_a: CL:0002548 ! fibroblast of cardiac tissue intersection_of: CL:0000057 ! fibroblast intersection_of: BFO:0000050 UBERON:0002082 ! part of cardiac ventricle relationship: BFO:0000050 UBERON:0002082 ! part of cardiac ventricle property_value: RO:0002175 NCBITaxon:9606 property_value: terms:contributor http://www.wikidata.org/entity/Q35563349 creation_date: 2014-10-07T18:35:38Z [Term] id: CL:2000067 name: cardiac atrium fibroblast def: "Any fibroblast that is part of a cardiac atrium." [GOC:TermGenie] comment: http://www.sciencellonline.com/site/productInformation.php?keyword=6320 subset: human_reference_atlas subset: human_subset subset: mouse_subset is_a: CL:0002548 ! fibroblast of cardiac tissue intersection_of: CL:0000057 ! fibroblast intersection_of: BFO:0000050 UBERON:0002081 ! part of cardiac atrium relationship: BFO:0000050 UBERON:0002081 ! part of cardiac atrium property_value: RO:0002175 NCBITaxon:9606 property_value: terms:contributor http://www.wikidata.org/entity/Q35563349 creation_date: 2014-10-07T18:36:54Z [Term] id: CL:2000068 name: pericardium fibroblast def: "Any fibroblast that is part of a pericardium." [GOC:TermGenie] comment: http://www.sciencellonline.com/site/productInformation.php?keyword=6430 subset: human_subset subset: mouse_subset is_a: CL:0000057 ! fibroblast intersection_of: CL:0000057 ! fibroblast intersection_of: BFO:0000050 UBERON:0002407 ! part of pericardium relationship: BFO:0000050 UBERON:0002407 ! part of pericardium property_value: terms:contributor http://www.wikidata.org/entity/Q35563349 creation_date: 2014-10-07T18:38:06Z [Term] id: CL:2000069 name: gallbladder fibroblast def: "Any fibroblast that is part of a gallbladder." [GOC:TermGenie] comment: http://www.sciencellonline.com/site/productInformation.php?keyword=5430 subset: human_subset subset: mouse_subset is_a: CL:0000057 ! fibroblast intersection_of: CL:0000057 ! fibroblast intersection_of: BFO:0000050 UBERON:0002110 ! part of gallbladder relationship: BFO:0000050 UBERON:0002110 ! part of gallbladder property_value: terms:contributor http://www.wikidata.org/entity/Q35563349 creation_date: 2014-10-07T18:41:43Z [Term] id: CL:2000070 name: optic choroid fibroblast def: "Any fibroblast that is part of a optic choroid." [GOC:TermGenie] comment: http://www.sciencellonline.com/site/productInformation.php?keyword=6620 subset: human_subset subset: mouse_subset is_a: CL:0000005 ! neural crest derived fibroblast is_a: CL:0000348 ! choroidal cell of the eye intersection_of: CL:0000057 ! fibroblast intersection_of: BFO:0000050 UBERON:0001776 ! part of optic choroid property_value: terms:contributor http://www.wikidata.org/entity/Q35563349 creation_date: 2014-10-07T18:50:43Z [Term] id: CL:2000071 name: mammary microvascular endothelial cell def: "Any microvascular endothelial cell that is part of a breast." [GOC:TermGenie] comment: http://www.sciencellonline.com/site/productInformation.php?keyword=7600 subset: human_subset subset: mouse_subset is_a: CL:2000008 ! microvascular endothelial cell intersection_of: CL:2000008 ! microvascular endothelial cell intersection_of: BFO:0000050 UBERON:0000310 ! part of breast relationship: BFO:0000050 UBERON:0000310 ! part of breast property_value: terms:contributor http://www.wikidata.org/entity/Q35563349 creation_date: 2014-10-07T19:55:30Z [Term] id: CL:2000072 name: adipose microvascular endothelial cell def: "Any microvascular endothelial cell that is part of a adipose tissue." [GOC:TermGenie] comment: http://www.sciencellonline.com/site/productInformation.php?keyword=7200 subset: human_subset subset: mouse_subset is_a: CL:0002320 ! connective tissue cell is_a: CL:2000008 ! microvascular endothelial cell intersection_of: CL:2000008 ! microvascular endothelial cell intersection_of: BFO:0000050 UBERON:0001013 ! part of adipose tissue relationship: BFO:0000050 UBERON:0001013 ! part of adipose tissue property_value: terms:contributor http://www.wikidata.org/entity/Q35563349 creation_date: 2014-10-07T22:13:45Z [Term] id: CL:2000073 name: migratory cardiac neural crest cell def: "Any migratory neural crest cell that is part of a cardiac neural crest." [GOC:TermGenie] subset: human_subset subset: mouse_subset synonym: "cardiac neural crest cell" EXACT [PMID:33060096] is_a: CL:0000333 ! migratory neural crest cell intersection_of: CL:0000333 ! migratory neural crest cell intersection_of: BFO:0000050 UBERON:0000095 ! part of cardiac neural crest relationship: BFO:0000050 UBERON:0000095 ! part of cardiac neural crest property_value: terms:contributor http://www.wikidata.org/entity/Q35563349 creation_date: 2014-11-05T01:18:43Z [Term] id: CL:2000074 name: splenocyte def: "Any leukocyte that is part of a spleen." [GOC:TermGenie] comment: Splenocytes is a vague term that refers to any one of the different white blood cell types in the spleen. This name is seen many references as such and is not explained further, necessitating a need for this terminology. subset: human_subset subset: mouse_subset is_a: CL:0000738 ! leukocyte intersection_of: CL:0000738 ! leukocyte intersection_of: BFO:0000050 UBERON:0002106 ! part of spleen relationship: BFO:0000050 UBERON:0002106 ! part of spleen property_value: terms:contributor http://www.wikidata.org/entity/Q35563349 creation_date: 2014-11-05T01:26:50Z [Term] id: CL:2000075 name: anterior visceral endoderm cell def: "Any endodermal cell that is part of a anterior visceral endoderm." [GOC:TermGenie] subset: human_subset subset: mouse_subset is_a: CL:0000223 ! endodermal cell intersection_of: CL:0000223 ! endodermal cell intersection_of: BFO:0000050 UBERON:0004044 ! part of anterior visceral endoderm relationship: BFO:0000050 UBERON:0004044 ! part of anterior visceral endoderm property_value: terms:contributor http://www.wikidata.org/entity/Q35563349 creation_date: 2014-11-05T01:34:13Z [Term] id: CL:2000076 name: hindlimb stylopod vein endothelial cell def: "Any vein endothelial cell that is part of a hindlimb stylopod." [GOC:TermGenie] subset: human_subset subset: mouse_subset is_a: CL:0002543 ! vein endothelial cell intersection_of: CL:0002543 ! vein endothelial cell intersection_of: BFO:0000050 UBERON:0000376 ! part of hindlimb stylopod relationship: BFO:0000050 UBERON:0000376 ! part of hindlimb stylopod property_value: terms:contributor http://www.wikidata.org/entity/Q35563349 creation_date: 2014-12-02T18:40:47Z [Term] id: CL:2000077 name: skeletal muscle tissue of pectoralis major striated muscle cell def: "Any striated muscle cell that is part of a skeletal muscle tissue of pectoralis major." [GOC:TermGenie] subset: human_subset subset: mouse_subset is_a: CL:0000188 ! cell of skeletal muscle is_a: CL:0000737 ! striated muscle cell intersection_of: CL:0000737 ! striated muscle cell intersection_of: BFO:0000050 UBERON:0004510 ! part of skeletal muscle tissue of pectoralis major relationship: BFO:0000050 UBERON:0004510 ! part of skeletal muscle tissue of pectoralis major property_value: terms:contributor http://www.wikidata.org/entity/Q35563349 creation_date: 2014-12-02T18:48:17Z [Term] id: CL:2000078 name: placental pericyte def: "Any pericyte cell that is part of a placenta." [GOC:TermGenie] subset: human_subset subset: mouse_subset is_a: CL:0000669 ! pericyte intersection_of: CL:0000669 ! pericyte intersection_of: BFO:0000050 UBERON:0001987 ! part of placenta relationship: BFO:0000050 UBERON:0001987 ! part of placenta property_value: terms:contributor http://www.wikidata.org/entity/Q35563349 creation_date: 2014-12-02T18:51:03Z [Term] id: CL:2000079 name: mesenchymal stem cell of femoral bone marrow def: "Any mesenchymal stem cell of the bone marrow that is part of a femur." [GOC:TermGenie] subset: human_subset subset: mouse_subset is_a: CL:0002540 ! mesenchymal stem cell of the bone marrow intersection_of: CL:0002540 ! mesenchymal stem cell of the bone marrow intersection_of: BFO:0000050 UBERON:0000981 ! part of femur relationship: BFO:0000050 UBERON:0000981 ! part of femur property_value: terms:contributor http://www.wikidata.org/entity/Q35563349 creation_date: 2014-12-02T19:07:31Z [Term] id: CL:2000080 name: mesenchymal stem cell of abdominal adipose tissue def: "Any mesenchymal stem cell of adipose tissue that is part of an abdomen." [GOC:TermGenie] subset: human_subset subset: mouse_subset synonym: "mesenchymal stem cell of abdominal adipose" EXACT [] is_a: CL:0002570 ! mesenchymal stem cell of adipose tissue intersection_of: CL:0002570 ! mesenchymal stem cell of adipose tissue intersection_of: BFO:0000050 UBERON:0000916 ! part of abdomen relationship: BFO:0000050 UBERON:0000916 ! part of abdomen property_value: terms:contributor http://www.wikidata.org/entity/Q35563349 creation_date: 2014-12-02T19:10:34Z [Term] id: CL:2000081 name: melanocyte of skin of face def: "Any melanocyte of skin that is part of a skin of face." [GOC:TermGenie] subset: human_subset subset: mouse_subset is_a: CL:1000458 ! melanocyte of skin intersection_of: CL:1000458 ! melanocyte of skin intersection_of: BFO:0000050 UBERON:1000021 ! part of skin of face relationship: BFO:0000050 UBERON:1000021 ! part of skin of face property_value: terms:contributor http://www.wikidata.org/entity/Q35563349 creation_date: 2014-12-02T19:10:40Z [Term] id: CL:2000082 name: obsolete melanocyte of foreskin def: "OBSOLETE. Any melanocyte of skin that is part of a skin of prepuce of penis." [GOC:TermGenie] comment: Term was merged into foreskin melanocyte CL_2000045 property_value: IAO:0000233 https://github.com/obophenotype/cell-ontology/issues/1562 property_value: terms:contributor http://www.wikidata.org/entity/Q35563349 is_obsolete: true replaced_by: CL:2000045 creation_date: 2014-12-02T19:10:45Z [Term] id: CL:2000083 name: hair follicle dermal papilla cell of scalp def: "Any hair follicle dermal papilla cell that is part of a scalp." [GOC:TermGenie] subset: human_subset subset: mouse_subset is_a: CL:0000346 ! hair follicle dermal papilla cell intersection_of: CL:0000346 ! hair follicle dermal papilla cell intersection_of: BFO:0000050 UBERON:0000403 ! part of scalp relationship: BFO:0000050 UBERON:0000403 ! part of scalp property_value: terms:contributor http://www.wikidata.org/entity/Q35563349 creation_date: 2014-12-02T19:10:50Z [Term] id: CL:2000084 name: conjunctiva goblet cell def: "A goblet cell that is part of the conjunctival epithelium, characterized by apical accumulation of mucin granules (containing MUC5AC in humans; Muc5ac/Muc5b in mice). These gel-forming mucins support tear film stability, ocular lubrication, and pathogen defence. The conjunctival goblet cell forms tight junctions with neighbouring epithelial cells via species-specific claudins (claudin-10 in humans, claudin-2 in mice) and regulates immune homeostasis by facilitating soluble antigen transport to dendritic cells through goblet cell-associated antigen passages (GAPs) (Barbosa et al., 2017). The transcription factor SPDEF is essential for its differentiation." [GOC:TermGenie, PMID:27091323, PMID:28475124, PMID:31734511] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "CGC" RELATED OMO:0003000 [PMID:31734511] is_a: CL:0000160 ! goblet cell is_a: CL:1000432 ! conjunctival epithelial cell intersection_of: CL:0000160 ! goblet cell intersection_of: BFO:0000050 UBERON:0006763 ! part of epithelium of conjunctiva relationship: BFO:0000050 UBERON:0006763 ! part of epithelium of conjunctiva property_value: terms:contributor http://www.wikidata.org/entity/Q35563349 creation_date: 2014-12-02T19:28:38Z [Term] id: CL:2000085 name: mononuclear cell of umbilical cord def: "Any mononuclear cell that is part of a umbilical cord." [GOC:TermGenie] subset: human_subset subset: mouse_subset is_a: CL:0000349 ! extraembryonic cell is_a: CL:0000842 ! mononuclear leukocyte intersection_of: CL:0000842 ! mononuclear leukocyte intersection_of: BFO:0000050 UBERON:0002331 ! part of umbilical cord relationship: BFO:0000050 UBERON:0002331 ! part of umbilical cord property_value: terms:contributor http://www.wikidata.org/entity/Q35563349 creation_date: 2014-12-02T20:14:16Z [Term] id: CL:2000086 name: neocortex basket cell def: "Any basket cell that is part of a neocortex." [GOC:TermGenie] subset: human_subset subset: mouse_subset is_a: CL:0000118 ! basket cell is_a: CL:0010011 ! cerebral cortex GABAergic interneuron intersection_of: CL:0000118 ! basket cell intersection_of: RO:0002100 UBERON:0001950 ! has soma location neocortex relationship: RO:0002100 UBERON:0001950 ! has soma location neocortex property_value: terms:contributor http://www.wikidata.org/entity/Q35563349 creation_date: 2014-12-24T00:37:19Z [Term] id: CL:2000087 name: dentate gyrus of hippocampal formation basket cell def: "Any basket cell that is part of a dentate gyrus of hippocampal formation." [GOC:TermGenie] subset: human_subset subset: mouse_subset is_a: CL:0000118 ! basket cell is_a: CL:0010011 ! cerebral cortex GABAergic interneuron is_a: CL:1001569 ! hippocampal interneuron is_a: CL:4023062 ! dentate gyrus neuron intersection_of: CL:0000118 ! basket cell intersection_of: RO:0002100 UBERON:0001885 ! has soma location dentate gyrus of hippocampal formation property_value: terms:contributor http://www.wikidata.org/entity/Q35563349 creation_date: 2014-12-24T00:37:24Z [Term] id: CL:2000088 name: Ammon's horn basket cell def: "Any basket cell that is part of a Ammon's horn." [GOC:TermGenie] subset: human_subset subset: mouse_subset is_a: CL:0000118 ! basket cell is_a: CL:0010011 ! cerebral cortex GABAergic interneuron is_a: CL:1001569 ! hippocampal interneuron intersection_of: CL:0000118 ! basket cell intersection_of: RO:0002100 UBERON:0001954 ! has soma location Ammon's horn relationship: RO:0002100 UBERON:0001954 ! has soma location Ammon's horn property_value: terms:contributor http://www.wikidata.org/entity/Q35563349 creation_date: 2014-12-24T00:37:30Z [Term] id: CL:2000089 name: dentate gyrus granule cell def: "A granule cell that has soma location in the dentate gyrus cell layer of the hippocampal formation and has an elliptical cell body and characteristic cone-shaped tree of spiny apical dendrites. The branches extend throughout the molecular layer and the distal tips of the dendritic tree end just at the hippocampal fissure or at the ventricular surface. The dentate gyrus granule cell is the principal cell type of the dentate gyrus." [GOC:TermGenie, PMID:17765709] comment: As far as can be determined, all dentate granule cells appear to project to CA3 and the axon trajectory is partially correlated with the position of the parent cell body. {xref="PMID:17765709"} subset: human_subset subset: mouse_subset synonym: "dentate gyrus of hippocampal formation granule cell" EXACT [] is_a: CL:0001033 ! hippocampal granule cell is_a: CL:4023062 ! dentate gyrus neuron intersection_of: CL:0001033 ! hippocampal granule cell intersection_of: RO:0002100 UBERON:0005381 ! has soma location dentate gyrus granule cell layer relationship: RO:0002100 UBERON:0005381 ! has soma location dentate gyrus granule cell layer property_value: skos:prefLabel "dentate gyrus granule cell" xsd:string property_value: terms:contributor http://www.wikidata.org/entity/Q35563349 creation_date: 2015-02-23T05:48:23Z [Term] id: CL:2000090 name: dentate gyrus of hippocampal formation stellate cell def: "Any stellate cell that is part of a dentate gyrus of hippocampal formation." [GOC:TermGenie] subset: human_subset subset: mouse_subset is_a: CL:0000122 ! stellate neuron is_a: CL:4023062 ! dentate gyrus neuron intersection_of: CL:0000122 ! stellate neuron intersection_of: RO:0002100 UBERON:0001885 ! has soma location dentate gyrus of hippocampal formation property_value: terms:contributor http://www.wikidata.org/entity/Q35563349 creation_date: 2015-02-23T05:48:40Z [Term] id: CL:2000091 name: endometrial microvascular endothelial cell def: "Any microvascular endothelial cell that is part of a endometrial blood vessel." [GOC:TermGenie] subset: human_reference_atlas subset: human_subset subset: mouse_subset is_a: CL:0009095 ! endothelial cell of uterus is_a: CL:2000008 ! microvascular endothelial cell intersection_of: CL:2000008 ! microvascular endothelial cell intersection_of: BFO:0000050 UBERON:0015172 ! part of endometrial blood vessel relationship: BFO:0000050 UBERON:0015172 ! part of endometrial blood vessel property_value: RO:0002175 NCBITaxon:9606 property_value: terms:contributor http://www.wikidata.org/entity/Q35563349 creation_date: 2015-03-31T21:02:36Z [Term] id: CL:2000092 name: hair follicular keratinocyte def: "Any keratinocyte that is part of a hair follicle." [GOC:TermGenie] subset: cellxgene_subset subset: human_subset subset: mouse_subset is_a: CL:0002559 ! hair follicle cell is_a: CL:4052061 ! epidermal keratinocyte intersection_of: CL:0000312 ! keratinocyte intersection_of: BFO:0000050 UBERON:0002073 ! part of hair follicle property_value: terms:contributor http://www.wikidata.org/entity/Q35563349 creation_date: 2015-03-31T21:07:02Z [Term] id: CL:2000093 name: bronchus fibroblast of lung def: "Any fibroblast of lung that is part of a bronchus." [GOC:TermGenie] subset: cellxgene_subset subset: human_subset subset: mouse_subset is_a: CL:0002553 ! fibroblast of lung intersection_of: CL:0002553 ! fibroblast of lung intersection_of: BFO:0000050 UBERON:0002185 ! part of bronchus relationship: BFO:0000050 UBERON:0002185 ! part of bronchus property_value: terms:contributor http://www.wikidata.org/entity/Q35563349 creation_date: 2015-03-31T21:16:22Z [Term] id: CL:2000094 name: nasal cavity respiratory epithelium epithelial cell of viscerocranial mucosa def: "Any epithelial cell of viscerocranial mucosa that is part of a nasal cavity respiratory epithelium." [GOC:TermGenie] subset: human_subset subset: mouse_subset is_a: CL:0002631 ! epithelial cell of upper respiratory tract is_a: CL:1000441 ! epithelial cell of viscerocranial mucosa intersection_of: CL:1000441 ! epithelial cell of viscerocranial mucosa intersection_of: BFO:0000050 UBERON:0005385 ! part of nasal cavity respiratory epithelium relationship: BFO:0000050 UBERON:0005385 ! part of nasal cavity respiratory epithelium property_value: terms:contributor http://www.wikidata.org/entity/Q35563349 creation_date: 2015-03-31T22:25:17Z [Term] id: CL:2000095 name: cord blood hematopoietic stem cell def: "Any hematopoietic stem cell that is part of a umbilical cord blood." [GOC:TermGenie] subset: cellxgene_subset subset: human_subset subset: mouse_subset is_a: CL:0002246 ! peripheral blood stem cell is_a: CL:0002352 ! gestational hematopoietic stem cell intersection_of: CL:0000037 ! hematopoietic stem cell intersection_of: BFO:0000050 UBERON:0012168 ! part of umbilical cord blood relationship: BFO:0000050 UBERON:0012168 ! part of umbilical cord blood property_value: terms:contributor http://www.wikidata.org/entity/Q35563349 creation_date: 2015-05-26T18:58:34Z [Term] id: CL:2000096 name: fibroblast of the reticular layer of dermis def: "A fibroblast of dermis that resides in the deep reticular layer, characterised by robust extracellular matrix production with high type I collagen deposition forming densely packed, organised fibrillar networks (Ghetti et al., 2018). This cell exhibits pro-fibrotic properties during wound healing, entering wounds early where it proliferates and deposits collagen to restore dermal architecture (Knoedler et al., 2023; McAndrews et al., 2022). It is distinguished from papillary dermal fibroblasts by expression of COL11A1, POSTN, and SPP1 in humans (Wu et al., 2022)." [GOC:TermGenie, PMID:29266210, PMID:35212000, PMID:36232952, PMID:37646029] subset: human_subset subset: mouse_subset synonym: "reticular fibroblast" RELATED [PMID:29266210] is_a: CL:0000151 ! secretory cell is_a: CL:0002551 ! fibroblast of dermis intersection_of: CL:0000057 ! fibroblast intersection_of: BFO:0000050 UBERON:0001993 ! part of reticular layer of dermis relationship: BFO:0000050 UBERON:0001993 ! part of reticular layer of dermis relationship: RO:0002215 GO:0070278 ! capable of extracellular matrix constituent secretion relationship: RO:0002292 PR:Q15063 ! expresses periostin (human) relationship: RO:0003000 GO:0005584 ! produces collagen type I trimer property_value: terms:contributor http://www.wikidata.org/entity/Q35563349 property_value: terms:contributor https://orcid.org/0009-0000-8480-9277 creation_date: 2015-08-11T16:28:16Z [Term] id: CL:2000097 name: midbrain dopaminergic neuron def: "Any dopaminergic neuron that is part of a midbrain." [GOC:TermGenie] subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset is_a: CL:0000700 ! dopaminergic neuron is_a: CL:2000029 ! central nervous system neuron intersection_of: CL:0000700 ! dopaminergic neuron intersection_of: RO:0002100 UBERON:0001891 ! has soma location midbrain relationship: RO:0002100 UBERON:0001891 ! has soma location midbrain property_value: RO:0002175 NCBITaxon:9606 property_value: terms:contributor http://www.wikidata.org/entity/Q35563349 creation_date: 2015-12-03T16:42:40Z [Term] id: CL:3000000 name: ciliated epithelial cell of esophagus def: "A ciliated epithelial cell of the esophagus." [GOC:CellBLAST, PMID:29802404] subset: human_subset subset: mouse_subset is_a: CL:0002252 ! epithelial cell of esophagus property_value: terms:contributor http://www.wikidata.org/entity/Q97529981 creation_date: 2019-02-09T16:40:30Z [Term] id: CL:3000001 name: Hofbauer cell def: "A tissue-resident macrophage that is part of the placenta. A Hofbauer cell expresses high levels of growth factors and metalloproteinases that support vasculogenesis, angiogenesis, branching morphogenesis and tissue remodeling. A Hofbauer cell has a fetal origin, is found in the villous stroma, chorion, and amnion, and is present throughout pregnancy." [GOC:CellBLAST, PMID:30429548, PMID:30498493, PMID:34745147, PMID:35438172] comment: Hofbauer cells are a heterogenic group of macrophages that resemble M2-like cells. Initially described in chorionic villi in humans, a Hofbauer cell is now often used to describe any fetal-derived placental macrophage that resides within the placental villous core, amnion, and chorion laeve. {xref="PMID:30498493"} subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "fetal Hofbauer cell" EXACT [PMID:39007150] synonym: "HBC" RELATED OMO:0003000 [PMID:39007150] is_a: CL:4033087 ! placental resident macrophage property_value: RO:0002175 NCBITaxon:9606 property_value: terms:contributor http://www.wikidata.org/entity/Q97529981 property_value: terms:contributor https://orcid.org/0000-0001-6677-8489 creation_date: 2019-02-18T19:41:20Z [Term] id: CL:3000002 name: sympathetic noradrenergic neuron def: "Sympathetic noradrenergic neuron." [GOC:CellBLAST, PMID:30096314] subset: human_reference_atlas subset: human_subset subset: mouse_subset is_a: CL:0008025 ! noradrenergic neuron is_a: CL:0011103 ! sympathetic neuron intersection_of: CL:0011103 ! sympathetic neuron intersection_of: RO:0002215 GO:0061533 ! capable of norepinephrine secretion, neurotransmission property_value: RO:0002175 NCBITaxon:9606 property_value: terms:contributor http://www.wikidata.org/entity/Q97529981 creation_date: 2019-02-25T19:30:14Z [Term] id: CL:3000003 name: sympathetic cholinergic neuron def: "A type of autonomic neuron that releases acetylcholine." [GOC:CellBLAST, PMID:30096314] subset: human_subset subset: mouse_subset is_a: CL:0000108 ! cholinergic neuron is_a: CL:0011103 ! sympathetic neuron intersection_of: CL:0011103 ! sympathetic neuron intersection_of: RO:0002215 GO:0014055 ! capable of acetylcholine secretion, neurotransmission property_value: terms:contributor http://www.wikidata.org/entity/Q97529981 creation_date: 2019-02-25T19:32:20Z [Term] id: CL:3000004 name: peripheral sensory neuron def: "A neuron type that is located in a peripheral nervous system and it transmits sensory information from the peripheral (PNS) to the central nervous system (CNS). A sensory neuron converts physical (light, sound, touch) or chemical (such as taste and smell) stimuli into an electrical signal through a process known as sensory transduction. The function of a sensory neuron is to carry informations from the external environment and internal body conditions to the central nervous system for further processing." [GOC:CellBLAST, https://www.britannica.com/science/sensory-neuron, https://www.ncbi.nlm.nih.gov/books/NBK539846/, PMID:30096314, PMID:31554486, PMID:35858549, Wikipedia:Sensory_neuron] comment: Typically, a sensory neuron has a pseudounipolar morphology. {xref="Wikipedia:Sensory_neuron"} subset: human_subset subset: mouse_subset is_a: CL:0000101 ! sensory neuron is_a: CL:2000032 ! peripheral nervous system neuron intersection_of: CL:2000032 ! peripheral nervous system neuron intersection_of: RO:0002215 GO:0050906 ! capable of detection of stimulus involved in sensory perception property_value: terms:contributor http://www.wikidata.org/entity/Q97529981 creation_date: 2019-02-25T19:34:33Z [Term] id: CL:4006000 name: fibroblast of breast def: "A fibroblast that is part of the breast." [] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "breast fibroblast" EXACT [] is_a: CL:0000057 ! fibroblast intersection_of: CL:0000057 ! fibroblast intersection_of: BFO:0000050 UBERON:0000310 ! part of breast relationship: BFO:0000050 UBERON:0000310 ! part of breast property_value: terms:contributor https://orcid.org/0000-0001-9897-3238 [Term] id: CL:4006001 name: fibroblast of skin of scalp def: "A fibroblast that is part of the skin of scalp." [] subset: human_subset subset: mouse_subset synonym: "skin of scalp fibroblast" EXACT [] is_a: CL:0002620 ! skin fibroblast intersection_of: CL:0000057 ! fibroblast intersection_of: BFO:0000050 UBERON:8300000 ! part of skin of scalp relationship: BFO:0000050 UBERON:8300000 ! part of skin of scalp property_value: terms:contributor https://orcid.org/0000-0001-9897-3238 [Term] id: CL:4023000 name: beta motor neuron def: "A motor neuron that innervates both intrafusal and extrafusal muscle fibers. Low abundancy. They control both muscle contraction and responsiveness of the sensory feedback from muscle spindles." [PMID:25346659] subset: human_subset subset: mouse_subset is_a: CL:0008039 ! lower motor neuron relationship: RO:0002120 CL:0008046 ! synapsed to extrafusal muscle fiber relationship: RO:0002120 CL:0008047 ! synapsed to intrafusal muscle fiber property_value: terms:contributor https://orcid.org/0000-0001-7258-9596 [Term] id: CL:4023001 name: static beta motor neuron def: "A beta motor neuron that innervates nuclear chain fibers." [PMID:25346659] subset: human_subset subset: mouse_subset is_a: CL:4023000 ! beta motor neuron property_value: terms:contributor https://orcid.org/0000-0001-7258-9596 [Term] id: CL:4023002 name: dynamic beta motor neuron def: "A beta motor neuron that innervates the nuclear bag fibers of muscle spindles." [PMID:25346659] subset: human_subset subset: mouse_subset is_a: CL:4023000 ! beta motor neuron property_value: terms:contributor https://orcid.org/0000-0001-7258-9596 [Term] id: CL:4023003 name: nuclear chain fiber def: "A type of intrafusal muscle fiber that has nuclei arranged in a linear row. Unlike nuclear bag fibers, the equatorial region of these fibers (in the centre of the spindle) is not expanded. These fibers are responsible for the detection of changes in muscle length. They are innervated by static gamma motor neurons and are principally associated with type II sensory fibers." [DOI:10.1016/B978-0-323-39632-5.00024-4, PMID:139469] subset: human_subset subset: mouse_subset is_a: CL:0008047 ! intrafusal muscle fiber property_value: terms:contributor https://orcid.org/0000-0001-7258-9596 [Term] id: CL:4023004 name: nuclear bag fiber def: "A type of intrafusal muscle fiber that lies in the center of a muscle spindle. Nuclei are clustered centrally and give the equatorial region a swollen appearance. They are associated with associated with dynamic gamma motor neurons, and the stretching of the equatorial region of the nuclear bag fibers results in an increase in the firing rate of type Ia sensory fibers." [DOI:10.1016/B978-0-323-39632-5.00024-4, PMID:139469] subset: human_subset subset: mouse_subset is_a: CL:0008047 ! intrafusal muscle fiber property_value: terms:contributor https://orcid.org/0000-0001-7258-9596 [Term] id: CL:4023005 name: dynamic nuclear bag fiber def: "A nuclear bag fiber that is sensitive mainly to the rate of change in muscle length." [DOI:10.1016/B978-0-323-39632-5.00024-4] subset: human_subset subset: mouse_subset synonym: "bag1 fiber" EXACT [] synonym: "nuclear bag1 intrafusal fiber" EXACT [] is_a: CL:4023004 ! nuclear bag fiber property_value: terms:contributor https://orcid.org/0000-0001-7258-9596 [Term] id: CL:4023006 name: static nuclear bag fiber def: "A nuclear bag fiber that is sensitive only changes in muscle length but not the rate of that change." [DOI:10.1016/B978-0-323-39632-5.00024-4] subset: human_subset subset: mouse_subset synonym: "bag2 fiber" EXACT [] synonym: "nuclear bag2 intrafusal fiber" EXACT [] is_a: CL:4023004 ! nuclear bag fiber property_value: terms:contributor https://orcid.org/0000-0001-7258-9596 [Term] id: CL:4023007 name: L2/3 bipolar VIP GABAergic interneuron (Mmus) def: "A VIP GABAergic cortical interneuron with bipolar morphology, with a soma found in L2/3. L2/3 bipolar VIP cells have extending axons across all layers (with preferences for layers II/III and Va) and a dendritic tree that is vertically more restricted than deeper layer VIP cells and extend fewer dendrites into the layers outside their home layer (location of soma). L2/3 bipolar VIP cells have great variability in firing patterns, though most are continuous adapting. L2/3 bipolar VIP cells are more depolarized in their resting state, had less fast rectification, and had smaller after hyperpolarization than deeper VIP cells." [PMID:26420784] subset: BDS_subset subset: mouse_subset synonym: "L2/3 bipolar Vip (Mus musculus)" EXACT [] is_a: CL:0000103 ! bipolar neuron is_a: CL:4023016 ! VIP GABAergic interneuron relationship: RO:0002100 UBERON:8440000 ! has soma location cortical layer II/III relationship: RO:0002162 NCBITaxon:10090 ! in taxon Mus musculus relationship: RO:0002292 PR:P32648 ! expresses VIP peptides (mouse) property_value: IAO:0000028 "L2/3 bipolar VIP interneuron (Mus)" xsd:string property_value: terms:contributor https://orcid.org/0000-0001-7258-9596 [Term] id: CL:4023008 name: intratelencephalic-projecting glutamatergic cortical neuron def: "A glutamatergic neuron located in the cerebral cortex that projects to structures of telencephalic origins." [PMID:34616075] subset: BDS_subset subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "IT neuron" EXACT [doi:10.1038/s41467-021-24565-z] xref: ILX:0770100 is_a: CL:0000679 ! glutamatergic neuron is_a: CL:0010012 ! cerebral cortex neuron intersection_of: CL:0000679 ! glutamatergic neuron intersection_of: RO:0000053 PATO:0070034 ! has characteristic intratelencephalic projecting intersection_of: RO:0002100 UBERON:0000956 ! has soma location cerebral cortex relationship: RO:0000053 PATO:0070034 ! has characteristic intratelencephalic projecting property_value: IAO:0000028 "IT neuron" xsd:string property_value: RO:0002175 NCBITaxon:9606 property_value: terms:contributor https://orcid.org/0000-0001-7258-9596 [Term] id: CL:4023009 name: extratelencephalic-projecting glutamatergic cortical neuron def: "A glutamatergic neuron located in the cerebral cortex that projects to structures not derived from telencephalon." [DOI:10.1101/2020.10.19.343129] subset: BDS_subset subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "ET projecting neuron" EXACT [] xref: ILX:0770101 is_a: CL:0000679 ! glutamatergic neuron is_a: CL:0010012 ! cerebral cortex neuron intersection_of: CL:0000679 ! glutamatergic neuron intersection_of: RO:0000053 PATO:0070028 ! has characteristic extratelencephalic projecting intersection_of: RO:0002100 UBERON:0000956 ! has soma location cerebral cortex relationship: RO:0000053 PATO:0070028 ! has characteristic extratelencephalic projecting property_value: IAO:0000028 "ET glut" xsd:string property_value: RO:0002175 NCBITaxon:9606 property_value: terms:contributor https://orcid.org/0000-0001-7258-9596 [Term] id: CL:4023010 name: alpha7 GABAergic cortical interneuron (Mmus) def: "A GABAergic cortical interneuron that is strongly labelled for α7 nAChRs. These cells have soma found in L1 and have multipolar dendrites with vertically descending axonal collaterals that project deep into the column, usually branching and terminating in L5A." [PMID:30413647, PMID:33184512] comment: Unlike typical Lamp5 electrophysiology, A7 cells have Vip- and Sst-like firing properties, with active depolarizing hump at near-threshold membrane potentials, and larger hyperpolarization sag, stronger burst, and rebound firing. A7 cells have a transcriptomics signature that looks like Lamp5 GABAergic interneuron. {xref="PMID:33184512", xref="PMID:30413647", xref="DOI:10.1101/2020.10.19.343129"} subset: BDS_subset subset: mouse_subset synonym: "A7 cell (Mus musculus)" EXACT [] is_a: BFO:0000002 is_a: CL:0010011 ! cerebral cortex GABAergic interneuron relationship: RO:0002162 NCBITaxon:10090 ! in taxon Mus musculus relationship: RO:0002292 PR:000005460 ! expresses neuronal acetylcholine receptor subunit alpha-7 property_value: IAO:0000028 "A7 interneuron" xsd:string property_value: terms:contributor https://orcid.org/0000-0001-7258-9596 [Term] id: CL:4023011 name: lamp5 GABAergic interneuron def: "A transcriptomically distinct GABAergic neuron located in the cerebral cortex that expresses Lamp5." [https://cellxgene.cziscience.com/e/e4ddac12-f48f-4455-8e8d-c2a48a683437.cxg/, PMID:30382198, PMID:37824655] comment: The marker set LINC00298, KIT can identify the Human cell type lamp5 GABAergic interneuron in the neocortex with a confidence of 0.814687838 (NS-Forest FBeta value). {xref="https://doi.org/10.5281/zenodo.11165918"} subset: BDS_subset subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset xref: ILX:0770149 is_a: CL:4023064 ! caudal ganglionic eminence derived interneuron intersection_of: CL:0000099 ! interneuron intersection_of: RO:0002100 UBERON:0000956 ! has soma location cerebral cortex intersection_of: RO:0002215 GO:0061534 ! capable of gamma-aminobutyric acid secretion, neurotransmission intersection_of: RO:0002292 PR:000032148 ! expresses lysosome-associated membrane glycoprotein 5 relationship: RO:0002292 PR:000032148 ! expresses lysosome-associated membrane glycoprotein 5 relationship: RO:0015004 CLM:1000074 ! has characterizing marker set NS forest marker set of lamp5 GABAergic interneuron (Human neocortex). property_value: IAO:0000028 "Lamp5 interneuron" xsd:string property_value: RO:0002175 NCBITaxon:9606 property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_4023011" xsd:string {name="lamp5 GABAergic interneuron on CELLxGENE CellGuide"} property_value: terms:contributor https://orcid.org/0000-0001-7258-9596 property_value: terms:description "The lamp5 GABAergic cortical interneuron, also known as Lamp5 interneuron, is a specialized subtype of cortical interneurons predominantly found in cortical layers of the brain. These cells are principally identified by the expression of the lamp5 gene. This specific subclass of GABAergic cortical interneurons are among five subclasses recently defined for their marker gene expression, which include Sst, Pvalb, Vip, Lamp5, and Sncg. In addition, these interneurons synthesize and release gamma-aminobutyric acid (GABA), an inhibitory neurotransmitter, which gives them their GABAergic characteristic.\nWithin the cortical microcircuitry, the lamp5 GABAergic cortical interneurons play crucial roles in modulating neuronal excitability and synaptic transmission. GABA release from these interneurons results in the inhibition of post-synaptic neurons, effectively controlling their activity rates and preventing unchecked excitatory responses, ultimately helping in regulating the balance between excitation and inhibition. This balance is vital for maintaining normal brain functions and its disruption often leads to neuropathological conditions, such as epilepsy and Alzheimer's disease.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1007/s00401-022-02457-w", xref="DOI:10.1016/j.cell.2020.09.057", xref="DOI:10.1038/s41467-020-18752-7", xref="DOI:10.1371/journal.pone.0157052"} [Term] id: CL:4023012 name: near-projecting glutamatergic cortical neuron def: "A glutamatergic neuron located in the cerebral cortex that projects axons locally rather than distantly." [DOI:10.1101/2020.10.19.343129] subset: BDS_subset subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "NP neuron" EXACT [] xref: ILX:0770103 is_a: CL:0000679 ! glutamatergic neuron is_a: CL:0010012 ! cerebral cortex neuron intersection_of: CL:0000679 ! glutamatergic neuron intersection_of: RO:0000053 PATO:0070030 ! has characteristic near projecting intersection_of: RO:0002100 UBERON:0000956 ! has soma location cerebral cortex relationship: RO:0000053 PATO:0070030 ! has characteristic near projecting property_value: IAO:0000028 "NP glut neuron" xsd:string property_value: RO:0002175 NCBITaxon:9606 property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_4023012" xsd:string {name="near-projecting glutamatergic cortical neuron on CELLxGENE CellGuide"} property_value: terms:contributor https://orcid.org/0000-0001-7258-9596 property_value: terms:description "The near-projecting glutamatergic cortical neuron is a critical functional unit of the mammalian cerebral cortex, predominantly found in the brain's cortical layers. This neuron employs glutamate as its principal neurotransmitter, implying its role is primarily excitatory as glutamate is the chief excitatory neurotransmitter within the mammalian central nervous system and is essential for instigating action potentials. Unlike other glutamatergic projecting neurons, these neurons project their axons over shorter distances, usually within the same region of the brain, to communicate with nearby neurons or neural circuits, giving them their 'near-projecting' nomenclature. This local propagation ability allows for fine-tuned transmission of signals, supporting the enhancement of sophisticated neural mechanisms like sensory processing, learning, and memory.\nThe specific functions of near-projecting glutamatergic cortical neurons are determined by which cortical layers they are located in and which neurons are their main postsynaptic targets. As a fundamental component of the complex cortical circuitry, they act interdependently with their neighboring cells, modulating the delicately balanced excitation and inhibition system. Dysfunction of these glutamatergic neurons can contribute to neurological conditions like epilepsy, Alzheimer's, or other manifestations of neurotoxicity.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1016/j.conb.2014.01.015", xref="DOI:10.1016/j.neuron.2015.11.002", xref="DOI:10.1038/nrn3586", xref="DOI:10.1038/s41586-018-0654-5"} [Term] id: CL:4023013 name: corticothalamic-projecting glutamatergic cortical neuron def: "A glutamatergic neuron located in the cerebral cortex that projects to the thalamus." [DOI:10.1101/2020.10.19.343129] subset: BDS_subset subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "CT projecting neuron" EXACT [] is_a: CL:0000679 ! glutamatergic neuron is_a: CL:0010012 ! cerebral cortex neuron intersection_of: CL:0000679 ! glutamatergic neuron intersection_of: RO:0000053 PATO:0070029 ! has characteristic corticothalamic projecting intersection_of: RO:0002100 UBERON:0000956 ! has soma location cerebral cortex relationship: RO:0000053 PATO:0070029 ! has characteristic corticothalamic projecting property_value: IAO:0000028 "CT glut" xsd:string property_value: RO:0002175 NCBITaxon:9606 property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_4023013" xsd:string {name="corticothalamic-projecting glutamatergic cortical neuron on CELLxGENE CellGuide"} property_value: terms:contributor https://orcid.org/0000-0001-7258-9596 property_value: terms:description "The corticothalamic-projecting glutamatergic cortical neuron is a specific glutamatergic neuron found primarily in the cerebral cortex of the brain. These neurons are named for their synthesis of glutamate, the most abundant excitatory neurotransmitter in the nervous system. They play a pivotal role in supporting fundamental neural processing and communication by transmitting nerve signals to the thalamus from the cortex. These signals contribute to various high-level functions such as sensation, cognition, and motor commands.\nCorticothalamic-projecting glutamatergic cortical neurons are significant components of a larger corticothalamic circuit. They receive sensory information relayed from peripheral organs and integrate the data to ensure a coordinated and appropriate behavioral response. These types of neurons project their axons to different regions of the thalamus, creating a network that is crucial for sensory processing.\nThe functionality of these neurons is central to maintaining the brain's rhythmic activity, as their critical role in signal transmission affects almost all sensory experiences except for smell. Malfunction of these neurons can lead to disruption in information integration and processing, which is seen in various cognitive, neurological, and psychiatric disorders such as schizophrenia, Parkinson's disease, epilepsy, and Alzheimer’s disease.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1016/j.brainres.2017.09.014", xref="DOI:10.1016/j.conb.2008.09.002", xref="DOI:10.1152/jn.2001.86.1.1", xref="DOI:10.1523/JNEUROSCI.4023-14.2015", xref="DOI:10.3389/fnins.2012.00053"} [Term] id: CL:4023014 name: L5 VIP GABAergic interneuron (Mmus) def: "A VIP GABAergic cortical interneuron with a soma found in L5. L5 VIP cells have mostly local morphology with some deep-projecting axons. They show only moderate resistance, comparable to that of sst subclass and unlike typical VIP subclass cells that tend to show high input resistance. L5 VIP cells show particularly low resting membrane potential." [PMID:26420784, PMID:26612957] subset: BDS_subset subset: mouse_subset synonym: "L5 VIP (Mus musculus)" EXACT [] is_a: CL:4023016 ! VIP GABAergic interneuron relationship: RO:0002100 UBERON:0005394 ! has soma location cortical layer V relationship: RO:0002162 NCBITaxon:10090 ! in taxon Mus musculus relationship: RO:0002292 PR:P32648 ! expresses VIP peptides (mouse) property_value: IAO:0000028 "L5 VIP interneuron (Mus)" xsd:string property_value: terms:contributor https://orcid.org/0000-0001-7258-9596 [Term] id: CL:4023015 name: sncg GABAergic interneuron def: "A transcriptomically distinct GABAergic neuron located in the cerebral cortex that expresses Gamma-synuclein." [https://cellxgene.cziscience.com/e/e4ddac12-f48f-4455-8e8d-c2a48a683437.cxg/, PMID:33186530, PMID:37824655] comment: The marker set RXRG, THSD7B can identify the Human cell type sncg GABAergic interneuron in the neocortex with a confidence of 0.628943702 (NS-Forest FBeta value). {xref="https://doi.org/10.5281/zenodo.11165918"} subset: BDS_subset subset: cellxgene_subset subset: human_subset subset: mouse_subset xref: ILX:0770150 is_a: CL:4023064 ! caudal ganglionic eminence derived interneuron intersection_of: CL:0000099 ! interneuron intersection_of: RO:0002100 UBERON:0000956 ! has soma location cerebral cortex intersection_of: RO:0002215 GO:0061534 ! capable of gamma-aminobutyric acid secretion, neurotransmission intersection_of: RO:0002292 PR:000015325 ! expresses gamma-synuclein relationship: RO:0002292 PR:000015325 ! expresses gamma-synuclein relationship: RO:0015004 CLM:1000081 ! has characterizing marker set NS forest marker set of sncg GABAergic interneuron (Human neocortex). property_value: IAO:0000028 "sncg interneuron" xsd:string property_value: RO:0002175 NCBITaxon:9606 property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_4023015" xsd:string {name="sncg GABAergic interneuron on CELLxGENE CellGuide"} property_value: terms:contributor https://orcid.org/0000-0001-7258-9596 property_value: terms:description "The sncg GABAergic cortical interneuron belongs to a subclass of diverse interneurons that populate and function within the cerebral cortex. Predominantly found in the mammalian brain, they play a crucial role in maintaining the balance between excitation and inhibition. The naming of these interneurons follows the sncg gene they express, which stands for synuclein gamma. This specific subclass of GABAergic cortical interneurons are among five subclasses recently defined for their marker gene expression, which include Sst, Pvalb, Vip, Lamp5, and Sncg.\nGenerally, GABAergic cortical interneurons utilize gamma-aminobutyric acid (GABA) as their chief neurotransmitter. GABA, a potent inhibitory neurotransmitter within the mammalian central nervous system, works by reducing neuronal excitability, thereby contributing to the overall regulation of the brain's intricate signaling network. This inhibitory function is of utmost importance, as it ensures the correct functioning of cortical networks and prevents excessive neural activity that could lead to disorders such as epilepsy.\nSncg GABAergic cortical interneurons have a highly diverse morphology and physiology. They are categorized as 'local circuit' neurons due to their limited influencing range which typically encompasses only nearby neurons. Their roles include, but are not limited to, sensory perception, encoding behavioural state, regulating neural oscillations, coordinating network synchrony, controlling the timing of cortical information processing, and shaping synaptic plasticity. Specifically, sncg GABAergic cortical interneurons are inhibited by visual stimuli.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1016/j.cell.2020.09.057", xref="DOI:10.1016/j.neuron.2018.10.009", xref="DOI:10.1016/j.neuron.2021.01.003", xref="DOI:10.1038/s41586-018-0654-5", xref="DOI:10.1038/s41586-022-04915-7"} [Term] id: CL:4023016 name: VIP GABAergic interneuron def: "A transcriptomically distinct GABAergic neuron derived from the CGE and that expresses the vasoactive intestinal polypeptide. Its soma is located in the forebrain." [https://cellxgene.cziscience.com/e/e4ddac12-f48f-4455-8e8d-c2a48a683437.cxg/, PMID:33186530, PMID:37824655] comment: The marker set VIP can identify the Human cell type VIP GABAergic interneuron in the neocortex with a confidence of 0.855531344 (NS-Forest FBeta value). {xref="https://doi.org/10.5281/zenodo.11165918"} subset: BDS_subset subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "Vip" RELATED [ILX:0770151] synonym: "Vip GABAergic neuron" BROAD [ILX:0770151] synonym: "VIP interneuron" BROAD [PMID:33108272] synonym: "VIP neuron" BROAD [PMID:33108272] synonym: "VIP neuron" RELATED [PMID:36384143] synonym: "VIP type" RELATED [PMID:37824655] synonym: "VIP-Expressing GABAergic Neuron" BROAD [PMID:35221922] synonym: "VIP-IN" RELATED [PMID:33794534] xref: ILX:0770151 is_a: CL:4023064 ! caudal ganglionic eminence derived interneuron intersection_of: CL:0000099 ! interneuron intersection_of: RO:0002100 UBERON:0000956 ! has soma location cerebral cortex intersection_of: RO:0002215 GO:0061534 ! capable of gamma-aminobutyric acid secretion, neurotransmission intersection_of: RO:0002292 PR:000017299 ! expresses VIP peptides relationship: RO:0002292 PR:000017299 ! expresses VIP peptides relationship: RO:0015004 CLM:1000085 ! has characterizing marker set NS forest marker set of VIP GABAergic interneuron (Human neocortex). property_value: IAO:0000028 "VIP interneuron" xsd:string property_value: RO:0002175 NCBITaxon:9606 property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_4023016" xsd:string {name="VIP GABAergic interneuron on CELLxGENE CellGuide"} property_value: terms:contributor https://orcid.org/0000-0001-7258-9596 property_value: terms:description "The vip GABAergic cortical interneurons are a specific subset of inhibitory neurons found in the mammalian cerebral cortex. Named after the neuropeptide they typically release, vasoactive intestinal peptide, these neurons are also characterized by producing and releasing gamma-aminobutyric acid (GABA), which is the primary inhibitory neurotransmitter in the mammalian central nervous system. This specific subclass of GABAergic cortical interneurons are among five subclasses recently defined for their marker gene expression, which include Sst, Pvalb, Vip, Lamp5, and Sncg. These interneurons play a critical role in shaping the dynamics of neural circuitry and modulating the balance between excitation and inhibition in neuronal networks. \nRegarding their function, vip GABAergic cortical interneurons serve as integral regulators of cortical activity. They primarily target other inhibitory interneuron populations such as the somatostatin-expressing sncg GABAergic cortical interneuron and the parvalbumin-expressing pvalb GABAergic cortical interneuron. By inhibiting these neuron populations, vip GABAergic cortical interneurons indirectly promote the activity of excitatory neurons, thereby serving as key facilitators of cortical activation and plasticity. They become particularly engaged during complex cognitive tasks and sensory experiences, highlighting their role in information processing and adaptation to environmental changes.\nFurthermore, vip GABAergic interneurons have a unique feature of long-range axonal projections, allowing their influence to spread over wide cortical areas. Additionally, these cells display diversity in morphological, electrophysiological and molecular properties, indicating their multifunctional role in cortical functioning. Disruptions in the function of vip GABAergic interneurons have been associated with various neurological and psychiatric disorders, including schizophrenia and autism spectrum disorder, underscoring the importance of these cells for normal brain function.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1016/j.celrep.2023.112628", xref="DOI:10.1038/s41467-018-07162-5", xref="DOI:10.1038/s41586-018-0654-5", xref="DOI:10.1093/cercor/bhy227", xref="DOI:10.3389/fncel.2022.811484"} [Term] id: CL:4023017 name: sst GABAergic interneuron def: "A transcriptomically distinct GABAergic neuron located in the cerebral cortex that expresses somatostatin (sst) and derived from the MGE." [https://cellxgene.cziscience.com/e/9c63201d-bfd9-41a8-bbbc-18d947556f3d.cxg/, PMID:27477017, PMID:33742131, PMID:37824655] comment: The marker set SST, PLCH1 can identify the Human cell type sst GABAergic interneuron in the neocortex with a confidence of 0.842367005 (NS-Forest FBeta value). {xref="https://doi.org/10.5281/zenodo.11165918"} subset: BDS_subset subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "SOM+ inhibitory interneuron" RELATED [PMID:30001424] synonym: "somatostatin-expressing inhibitory interneuron" RELATED [PMID:30001424] synonym: "SST+ IN" RELATED [PMID:33742131] xref: ILX:0770152 is_a: CL:4023069 ! medial ganglionic eminence derived GABAergic interneuron intersection_of: CL:4023069 ! medial ganglionic eminence derived GABAergic interneuron intersection_of: RO:0002100 UBERON:0000956 ! has soma location cerebral cortex intersection_of: RO:0002215 GO:0061534 ! capable of gamma-aminobutyric acid secretion, neurotransmission intersection_of: RO:0002292 PR:000015665 ! expresses somatostatin relationship: RO:0002292 PR:000015665 ! expresses somatostatin relationship: RO:0015004 CLM:1000082 ! has characterizing marker set NS forest marker set of sst GABAergic interneuron (Human neocortex). property_value: IAO:0000028 "sst interneuron" xsd:string property_value: RO:0002175 NCBITaxon:9606 property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_4023017" xsd:string {name="sst GABAergic interneuron on CELLxGENE CellGuide"} property_value: terms:contributor https://orcid.org/0000-0001-7258-9596 property_value: terms:description "Sst GABAergic cortical interneuron or somatostatin-expressing GABAergic cortical interneuron, is a type of inhibitory neuron that regulates the activity of other neurons in the cerebral cortex, specifically in the mammalian neocortex. This cell type is named after the inhibitory neurotransmitter it releases, gamma-aminobutyric acid (GABA) and the particular neuropeptide it expresses, somatostatin (sst). Sst GABAergic cortical interneurons make up around 30% of all GABAergic neurons in the cortex and play a critical role in shaping cortical network dynamics and function. This specific subclass of GABAergic cortical interneurons are among five subclasses recently defined for their marker gene expression, which include Sst, Pvalb, Vip, Lamp5, and Sncg.\nSst GABAergic cortical interneurons are known for their diverse morphology, axonal projection pattern and electrophysiological properties, but they are most characterized by sst neuropeptide expression. Sst is a hormone that helps regulate the endocrine system and affects neurotransmission and cell proliferation via interaction with G protein-coupled somatostatin receptors. These interneurons typically make synapses onto the dendrites of excitatory pyramidal cells and other interneurons, controlling the input they receive. In doing so, they are primarily responsible for inhibiting and fine-tuning the output of cortical circuits.\nThe function of sst GABAergic cortical interneurons is essential to various cognitive processes, as they play influential roles in controlling the timing and spatial aspects of information processing in the brain. For instance, these cells modulate oscillatory rhythms, a key component of cognition and perception, and help mediate long-range cortico-cortical communication. Interestingly, dysfunctions associated with this cell type have been implicated in several neurological and psychiatric disorders including schizophrenia, autism, and epilepsy.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1016/j.neuron.2023.05.032", xref="DOI:10.1038/s41583-021-00443-x", xref="DOI:10.1038/s41586-018-0654-5", xref="DOI:10.1093/schbul/sbaa184", xref="DOI:10.3389/fncir.2016.00048"} [Term] id: CL:4023018 name: pvalb GABAergic interneuron def: "A transcriptomically distinct GABAergic interneuron with a soma located in the pallium. These neurons express Parvalbumin." [https://cellxgene.cziscience.com/e/9c63201d-bfd9-41a8-bbbc-18d947556f3d.cxg/, PMID:27477017, PMID:37824655] comment: Historically this term was used to refer to all Pvalb expressing GABAergic interneurons, but transcriptomic classification separates out some Pvalb expressing GABAergic interneurons as sibling classes (e.g. Pvalb chandelier). We follow the transcriptomic classifications. The marker set PVALB, TAC1, MYO5B can identify the Human cell type pvalb GABAergic interneuron in the neocortex with a confidence of 0.691998764 (NS-Forest FBeta value). {xref="https://doi.org/10.5281/zenodo.11165918"} subset: BDS_subset subset: cellxgene_subset subset: human_subset subset: mouse_subset xref: ILX:0770154 is_a: CL:0011005 ! GABAergic interneuron is_a: CL:0012001 ! neuron of the forebrain is_a: CL:4023063 ! medial ganglionic eminence derived interneuron relationship: RO:0002100 UBERON:0000203 ! has soma location pallium relationship: RO:0002292 PR:000013502 ! expresses parvalbumin alpha relationship: RO:0015004 CLM:1000080 ! has characterizing marker set NS forest marker set of pvalb GABAergic interneuron (Human neocortex). property_value: IAO:0000028 "pvalb interneuron" xsd:string property_value: RO:0002175 NCBITaxon:9606 property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_4023018" xsd:string {name="pvalb GABAergic interneuron on CELLxGENE CellGuide"} property_value: terms:contributor https://orcid.org/0000-0001-7258-9596 property_value: terms:description "The pvalb GABAergic cortical interneuron, named for its expression of parvalbumin (pvalb) and its use of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA), plays an essential role in the intricate circuitry of the brain. This specific subclass of GABAergic cortical interneurons are among five subclasses recently defined for their marker gene expression, which include Sst, Pvalb, Vip, Lamp5, and Sncg. Predominantly found within the cortex, this subset of interneurons exhibits a significant influence on the behavior of the local network due to their robust inhibitory capabilities. Sampling input from the surrounding pyramidal neurons while concomitantly providing feedback inhibitory connections makes pvalb cortical interneurons a crucial constituent of cortical homeostasis.\nFunctionally, pvalb GABAergic cortical interneurons are responsible for shaping neuronal activity and facilitating precisely timed and reliable information transfer within the brain. They offer inhibitory control over the excitatory neurons they synapse, allowing these cells to temper and shape the overall neuronal firing pattern in the cortical regions, thereby promoting functional efficiency and reliability. Moreover, these interneurons, by rapidly and repetitively firing, contribute to generating brain rhythms, particularly gamma oscillations, essential for cognitive functions, like perception, attention, and memory.\nDisruptions in the function of pvalb GABAergic cortical interneurons are linked to a broad spectrum of neurological and psychiatric disorders, including epilepsy, autism, and schizophrenia, indicating their central role in maintaining cortical functionality. Moreover, the distribution, density, and interconnectedness of these complex neuronal networks may vary depending on the specific cortical region, further influencing their functionality and consequently the global neuronal output of the cortical area.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1038/s41380-023-02153-5", xref="DOI:10.1038/s41386-020-0778-9", xref="DOI:10.1038/s41586-018-0654-5", xref="DOI:10.1126/science.1255263", xref="DOI:10.3389/fpsyt.2021.679960"} [Term] id: CL:4023019 name: L5/6 cck, VIP GABAergic interneuron (Mmus) def: "A VIP GABAergic cortical interneuron that expresses cck. L5/6 cck cells have soma found mainly in L5 and L6 and have large axonal arborization." [PMID:33184512] subset: BDS_subset subset: mouse_subset synonym: "L5/6 CCK Vip (Mus musculus)" EXACT [] is_a: CL:4023016 ! VIP GABAergic interneuron is_a: CL:4023071 ! L5/6 cck GABAergic interneuron (Mmus) intersection_of: CL:4023071 ! L5/6 cck GABAergic interneuron (Mmus) intersection_of: RO:0002292 PR:P32648 ! expresses VIP peptides (mouse) relationship: RO:0002292 PR:P32648 ! expresses VIP peptides (mouse) property_value: terms:contributor https://orcid.org/0000-0001-7258-9596 [Term] id: CL:4023020 name: dynamic gamma motor neuron def: "A gamma motor neuron that innervates dynamic nuclear bag fibers (bag1 fibers) and enhances the sensitivities of Ia sensory neurons. They alter muscle spindle sensitivity and increases its discharge in response to velocity of muscle length (rather than just magnitude)." [PMID:13933877, PMID:139469, WikipediaVersion:Gamma_motor_neuron&oldid=906640465] subset: human_subset subset: mouse_subset is_a: CL:0008037 ! gamma motor neuron relationship: RO:0002120 CL:4023005 ! synapsed to dynamic nuclear bag fiber property_value: terms:contributor https://orcid.org/0000-0001-7258-9596 [Term] id: CL:4023021 name: static gamma motor neuron def: "A gamma motor neuron that innervates static nuclear bag fibers (bag2 fibers) and increases their firing, in response to an increase in the magnitude of change in length, and controls the static sensitivity of the stretch reflex." [PMID:13933877, PMID:139469, WikipediaVersion:Gamma_motor_neuron&oldid=906640465] subset: human_subset subset: mouse_subset is_a: CL:0008037 ! gamma motor neuron relationship: RO:0002120 CL:4023006 ! synapsed to static nuclear bag fiber property_value: terms:contributor https://orcid.org/0000-0001-7258-9596 [Term] id: CL:4023022 name: canopy lamp5 GABAergic cortical interneuron (Mmus) def: "A Lamp5 GABAergic cortical interneuron that has extended axons in the surface of L1. Canopy Lamp5 cells resemble neurogliaform cells in having elongated horizontal axonal arbors largely confined to L1; but the dendritic arbors are wider and have fewer branches, while the axon is less tortuous and extends further from the soma" [PMID:30413647] subset: BDS_subset subset: mouse_subset is_a: CL:4023011 ! lamp5 GABAergic interneuron relationship: RO:0002162 NCBITaxon:10090 ! in taxon Mus musculus relationship: RO:0002292 PR:Q9D387 ! expresses lysosome-associated membrane glycoprotein 5 (mouse) property_value: IAO:0000028 "canopy lamp5 interneuron" xsd:string property_value: terms:contributor https://orcid.org/0000-0001-7258-9596 [Term] id: CL:4023023 name: L5,6 neurogliaform lamp5 GABAergic interneuron (Mmus) def: "A lamp 5 GABAergic cortical interneuron with neurogliaform morphology with a soma found in L5,6. L5,6 NGC lamp5 have deep afterhyperpolarization (AHP) but narrow action potentials (APs). Unlike other deep neurogliaform cells (which are caudal ganglionic eminence (CGE) derived), L5,6 NGC lamp5 cells are medial ganglionic eminence (MGE)-derived" [PMID:26727548] subset: BDS_subset subset: mouse_subset synonym: "L5,6 NGC Lamp5 (Mus musculus)" EXACT [] is_a: CL:0000693 ! neurogliaform cell is_a: CL:4023011 ! lamp5 GABAergic interneuron relationship: RO:0002162 NCBITaxon:10090 ! in taxon Mus musculus relationship: RO:0002292 PR:Q9D387 ! expresses lysosome-associated membrane glycoprotein 5 (mouse) property_value: IAO:0000028 "L5,6 NGC Lamp5 interneuron (Mus)" xsd:string property_value: terms:contributor https://orcid.org/0000-0001-7258-9596 [Term] id: CL:4023024 name: neurogliaform lamp5 GABAergic cortical interneuron (Mmus) def: "A lamp5 GABAergic cortical interneuron with layer-adapting morphology. NGC lamp5 cells have a small round soma, short dendrites, and a wide dense axonal arbor that tends to establish a dense axonal mesh with high connection probability both to themselves and L2 pyramidal cells. NGC lamp5 cells have unique synaptic properties that distinguish them from other GABAergic interneurons, including the release of GABA to the extracellular space via volume transmission, and the ability to produce GABA-B responses in connected postsynaptic targets." [PMID:27477017] subset: BDS_subset subset: mouse_subset synonym: "NGC Lamp5 (Mus musculus)" EXACT [] is_a: CL:0000693 ! neurogliaform cell is_a: CL:4023011 ! lamp5 GABAergic interneuron relationship: RO:0002162 NCBITaxon:10090 ! in taxon Mus musculus relationship: RO:0002292 PR:Q9D387 ! expresses lysosome-associated membrane glycoprotein 5 (mouse) property_value: IAO:0000028 "NGC Lamp5 interneuron (Mus)" xsd:string property_value: terms:contributor https://orcid.org/0000-0001-7258-9596 [Term] id: CL:4023025 name: long-range projecting sst GABAergic cortical interneuron (Mmus) def: "A sst GABAergic cortical interneuron that is both an interneuron and a projecting neuron. They are found in all layers from upper L2/3 down to the bottom of L6. They have long-range projections, some with axons fading into white matter. These cells have low rebound potential, low hyperpolarization sag, and high variability in membrane time constant." [PMID:26727548] subset: BDS_subset subset: mouse_subset synonym: "LP SST (Mus musculus)" EXACT [] is_a: CL:4023121 ! sst chodl GABAergic interneuron relationship: RO:0002162 NCBITaxon:10090 ! in taxon Mus musculus relationship: RO:0002292 PR:P60041 ! expresses somatostatin (mouse) property_value: terms:contributor https://orcid.org/0000-0001-7258-9596 [Term] id: CL:4023026 name: direct pathway medium spiny neuron def: "A GABAergic medium spiny neuron located in the striatum that gives rise to the direct basal ganglia pathway. It projects directly to the GPi and SNr, where it inhibits tonically active GABAergic output neurons to disinhibit thalamic and brainstem motor targets (Gerfen. 2023). In mice and humans, this cell selectively expresses the D1 dopamine receptor (DRD1), which couples to stimulatory G-proteins (Gs/Gαolf) to increase cAMP and activate PKA-dependent signaling cascades (Gerfen et al., 1990; Kebabian & Calne, 1979). Functionally, activation of this cell promotes selected motor actions by disinhibiting thalamic and midbrain motor centers (Mink, 1996; Cui et al., 2013)." [PMID:2147780, PMID:215920, PMID:23354054, PMID:34727523, PMID:36741471, PMID:9004351, WikipediaVersioned:Medium_spiny_neuron&oldid=1109726850] comment: Despite the direct and indirect circuits are often described not only as functionally opposing but also as anatomically segregated there are several anatomical and functional studies that have challenged this notion of pure segregation based on extensive collateral projections between pathways, dual-projection neurons, simultaneous co-activation during behavior. {xref="PMID:29737578", xref="PMID:26018615"} subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "D1-MSN" RELATED OMO:0003000 [PMID:34727523] synonym: "dopamine 1 medium spiny neuron" EXACT [https://orcid.org/0000-0001-7258-9596] synonym: "dSPN" RELATED OMO:0003000 [PMID:30096299, PMID:36741471] is_a: CL:1001474 ! medium spiny neuron relationship: RO:0002292 PR:000001175 ! expresses D(1A) dopamine receptor property_value: terms:contributor https://orcid.org/0000-0001-7258-9596 [Term] id: CL:4023027 name: L5 sst T-Martinotti interneuron (Mmus) def: "A sst GABAergic cortical interneuron with a soma found in L5 and possesses 'T-shaped' Martinotti morphologies with local axonal plexus in L5a and translaminar axons restricted to the uppermost part of L1. They show low-threshold spiking patterns with strong rebound firing, and inhibit the L1 apical tuft of nearby pyramidal cells." [PMID:28254942, PMID:29326172] subset: BDS_subset subset: mouse_subset synonym: "L5 T Martinotti SST (Mus musculus)" EXACT [] is_a: BFO:0000002 is_a: CL:0010011 ! cerebral cortex GABAergic interneuron is_a: CL:4023086 ! T Martinotti neuron relationship: RO:0002100 UBERON:0005394 ! has soma location cortical layer V relationship: RO:0002162 NCBITaxon:10090 ! in taxon Mus musculus relationship: RO:0002292 PR:P60041 ! expresses somatostatin (mouse) property_value: IAO:0000028 "L5 T Martinotti sst interneuron (Mus)" xsd:string property_value: terms:contributor https://orcid.org/0000-0001-7258-9596 [Term] id: CL:4023028 name: L5 non-Martinotti sst GABAergic interneuron (Mmus) def: "A sst GABAergic cortical interneuron with a soma found in lower L5 with mostly local axonal arborization but with some sparse ascending axons. L5 non-Martinotti sst cells show somatic localization and local axon plexus in L5b and L5b/6 and substantial innervation of L3 and L4, and receive thalamic input from the ventral posteromedial nucleus and specifically target L4 neurons, avoiding L5 pyramidal cells. L5 non-Martinotti sst cells tend to show a higher input resistance and seem to be less stuttering." [PMID:28254942, PMID:29326172] subset: BDS_subset subset: mouse_subset synonym: "L5 non-Martinotti SST (Mus musculus)" EXACT [] is_a: BFO:0000002 is_a: CL:0010011 ! cerebral cortex GABAergic interneuron relationship: RO:0002100 UBERON:0005394 ! has soma location cortical layer V relationship: RO:0002162 NCBITaxon:10090 ! in taxon Mus musculus relationship: RO:0002292 PR:P60041 ! expresses somatostatin (mouse) property_value: IAO:0000028 "L5 non-Martinotti sst interneuron (Mus)" xsd:string property_value: terms:contributor https://orcid.org/0000-0001-7258-9596 [Term] id: CL:4023029 name: indirect pathway medium spiny neuron def: "A GABAergic medium spiny neuron located in the striatum that gives rise to the indirect basal ganglia pathway. It projects to the GPe, where its axon typically ramifies in two regions but does not extend beyond this nucleus (Gerfen et al., 2022). It selectively expresses the D2 dopamine receptor (DRD2), which couples to inhibitory G-proteins (Gi/o) to decrease cAMP and suppress PKA-mediated signaling (Gerfen et al., 2022). Morphologically, this cell displays fewer and shorter dendrites than the MSN-D1 and receives fewer glutamatergic inputs, yet it exhibits significantly higher intrinsic excitability (Gertler et al., 2022). Functionally, activation of this cell suppresses competing or alternative motor actions by inhibiting GPe neurons, leading through STN and other GPe circuits to increased GPi/SNr output and stronger inhibition of thalamic and brainstem targets (Mink, 1996; Tecuapetla et al., 2016)." [PMID:27453468, PMID:34727523, PMID:36741471, PMID:9004351, WikipediaVersioned:Medium_spiny_neuron&oldid=1109726850] comment: Despite the direct and indirect circuits are often described not only as functionally opposing but also as anatomically segregated there are several anatomical and functional studies that have challenged this notion of pure segregation based on extensive collateral projections between pathways, dual-projection neurons, simultaneous co-activation during behavior. {xref="PMID:29737578", xref="PMID:26018615"} subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "D2-MSN" EXACT OMO:0003000 [PMID:34727523] synonym: "dopamine 2 medium spiny neuron" EXACT [https://orcid.org/0000-0001-7258-9596] synonym: "iSPN" EXACT OMO:0003000 [PMID:30096299] is_a: CL:1001474 ! medium spiny neuron relationship: RO:0002292 PR:000001177 ! expresses D(2) dopamine receptor property_value: terms:contributor https://orcid.org/0000-0001-7258-9596 [Term] id: CL:4023030 name: L2/3/5 fan Martinotti sst GABAergic interneuron (Mmus) def: "A sst GABAergic cortical interneuron that has \"fanning-out' Martinotti morphology that is found in layer 2/3/5 of the cerebral cortex. They have local axon arbor and long ascending axons that spreads horizontally and arborizes significantly in L1." [PMID:27225074, PMID:27477017, PMID:28254942, PMID:29326172] comment: L2/3/5 fan Martionotti SST cells have an adapting firing pattern and non-zero afterdepolarization (ADP). {xref="PMID:33184512"} subset: BDS_subset subset: mouse_subset synonym: "L2/3/5 fan Martinotti SST (Mus musculus)" EXACT [] is_a: BFO:0000002 is_a: CL:0010011 ! cerebral cortex GABAergic interneuron is_a: CL:4023087 ! fan Martinotti neuron relationship: RO:0002162 NCBITaxon:10090 ! in taxon Mus musculus relationship: RO:0002292 PR:P60041 ! expresses somatostatin (mouse) property_value: IAO:0000028 "L2/3/5 fan Martinotti sst interneuron (Mus)" xsd:string property_value: terms:contributor https://orcid.org/0000-0001-7258-9596 [Term] id: CL:4023031 name: L4 sst Martinotti interneuron (Mmus) def: "A sst GABAergic cortical interneuron with a soma found in lower L2/3 and upper 5, L4 Sst cells have Martinotti morphology with ascending axons but denser local axons and sparser ‘fanning-out’ projections to L1. L4 sst cells have smaller membrane time constant to calb2 (L2/3/5 fan Martinotti Cell) and non-zero afterdepolarization (ADP)." [PMID:33184512] subset: BDS_subset subset: mouse_subset synonym: "L4 SST (Mus musculus)" EXACT [] is_a: BFO:0000002 is_a: CL:0010011 ! cerebral cortex GABAergic interneuron is_a: CL:4023076 ! Martinotti neuron relationship: RO:0002100 UBERON:0005393 ! has soma location cortical layer IV relationship: RO:0002162 NCBITaxon:10090 ! in taxon Mus musculus relationship: RO:0002292 PR:P60041 ! expresses somatostatin (mouse) property_value: IAO:0000028 "L4 sst interneuron (Mus)" xsd:string property_value: terms:contributor https://orcid.org/0000-0001-7258-9596 [Term] id: CL:4023032 name: ON retinal ganglion cell comment: A retinal ganglion cell that is depolarized by illumination of its receptive field center. {xref="PMID:19602302"} subset: cellxgene_subset subset: human_subset subset: mouse_subset is_a: CL:0000740 ! retinal ganglion cell property_value: terms:contributor http://orcid.org/0000-0001-7258-9596 [Term] id: CL:4023033 name: OFF retinal ganglion cell def: "A retinal ganglion cell that is depolarized by decreased illumination of their receptive field center." [PMID:19602302] subset: cellxgene_subset subset: human_subset subset: mouse_subset is_a: CL:0000740 ! retinal ganglion cell property_value: terms:contributor http://orcid.org/0000-0001-7258-9596 [Term] id: CL:4023034 name: obsolete L2/3 pvalb-like sst GABAergic cortical interneuron (Mus musculus) def: "OBSOLETE A sst GABAergic cortical interneuron transcriptomically between the sst and the pvalb families with a soma found in L2/3. Some L2/3 PV-like sst cells have Martinotti morphology while some have basket cell morphology. L2/3 PV-like sst cells have lower AP width and higher firing rate than typical Sst subclass cells. L2/3 PV-like sst cells have high maximum firing rate variability, with many classified as belonging to the pvalb subclass on the basis of electrophysiology." [PMID:33184512] comment: Moved to PCL. Use PCL:1000002 instead. synonym: "L2/3 PV-like SST Mus)" EXACT [] property_value: IAO:0000233 https://github.com/obophenotype/brain_data_standards_ontologies/issues/231 property_value: terms:contributor https://orcid.org/0000-0001-7258-9596 is_obsolete: true replaced_by: PCL:1000002 [Term] id: CL:4023035 name: lateral ganglionic eminence derived neuron def: "A neuron that is derived from a precursor cell in the lateral ganglion eminence." [wikipediaversioned:Ganglionic_eminence&oldid=1186824360] subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "LGE-derived neuron" EXACT [PMID:10377350] is_a: BFO:0000002 is_a: CL:2000029 ! central nervous system neuron intersection_of: CL:0000540 ! neuron intersection_of: RO:0002202 UBERON:0004025 ! develops from lateral ganglionic eminence relationship: RO:0002202 UBERON:0004025 ! develops from lateral ganglionic eminence property_value: RO:0002175 NCBITaxon:9606 property_value: terms:contributor "https://orcid.org/0000-0001-7258-9596" xsd:string property_value: terms:contributor "https://orcid.org/0000-0002-7073-9172" xsd:string [Term] id: CL:4023036 name: pvalb chandelier GABAergic interneuron def: "A transcriptomically distinct pvalb GABAergic interneuron located in the pallium. It is recognizable by the straight terminal axonal 'cartridges' of vertically oriented strings of synaptic boutons. Chandelier PV cells' boutons target exclusively the axon initial segment (AIS) of pyramidal cells, with a single cell innervating hundreds of pyramidal cells in a clustered manner. These cells are fast-spiking." [PMID:15378039, PMID:27199673, PMID:27477017, PMID:37824655] comment: The marker set GPR149, CA8 can identify the Human cell type pvalb chandelier GABAergic interneuron in the neocortex with a confidence of 0.799748111 (NS-Forest FBeta value). {xref="https://doi.org/10.5281/zenodo.11165918"} subset: BDS_subset subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "axo-axonic cell" BROAD [PMID:27199673, PMID:33862423, PMID:39012795] synonym: "chandelier cell" EXACT [] synonym: "chandelier PV" EXACT [] synonym: "ChC" RELATED OMO:0003000 [PMID:15378039] xref: ILX:0107356 xref: ILX:0777213 {IAO:0000116="Interlex cross reference refers specifically to Markram 2015 rat chandelier cell."} is_a: CL:4023069 ! medial ganglionic eminence derived GABAergic interneuron relationship: RO:0000053 PATO:0070011 ! has characteristic chandelier cell morphology relationship: RO:0002292 PR:000013502 ! expresses parvalbumin alpha relationship: RO:0015004 CLM:1000063 ! has characterizing marker set NS forest marker set of pvalb chandelier GABAergic interneuron (Human neocortex). property_value: IAO:0000028 "Pvalb Chandelier" xsd:string property_value: RO:0002175 NCBITaxon:9606 property_value: terms:contributor https://orcid.org/0000-0001-7258-9596 [Term] id: CL:4023038 name: L6b glutamatergic cortical neuron def: "A glutamatergic neuron with a soma found in cortical layer 6b. They are transcriptomically related to corticothalamic-projecting neurons but have differential projections to the thalamus or anterior cingulate." [DOI:10.1101/2020.10.19.34312, https://cellxgene.cziscience.com/e/d01c9dff-abd1-4825-bf30-2eb2ba74597e.cxg/, PMID:30382198, PMID:37824655] subset: BDS_subset subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset xref: ILX:0770163 is_a: CL:0000679 ! glutamatergic neuron is_a: CL:0010012 ! cerebral cortex neuron intersection_of: CL:0000679 ! glutamatergic neuron intersection_of: RO:0002100 UBERON:8440003 ! has soma location cortical layer VIb relationship: RO:0002100 UBERON:8440003 ! has soma location cortical layer VIb property_value: IAO:0000028 "L6b glut" xsd:string property_value: RO:0002175 NCBITaxon:9606 property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_4023038" xsd:string {name="L6b glutamatergic cortical neuron on CELLxGENE CellGuide"} property_value: terms:contributor https://orcid.org/0000-0001-7258-9596 property_value: terms:description "The L6b glutamatergic cortical neuron, also known as the Layer 6b glutamatergic neuron, is a specific subtype of neuron predominantly located in layer 6b of the cerebral cortex. This region is the deepest layer of the grey matter in the brain, containing various types of neurons. The L6b glutamatergic cortical neurons are named for their primary excitatory neurotransmitter, glutamate, which they use to transmit signals across the synapse. A key feature of L6b glutamatergic cortical neurons is their distinctive morphological and molecular characteristics. They express various genes that are not commonly found in other types of cortical neurons, illustrating their unique genetic make-up and they also have a distinct morphology, with dendrites that span across multiple layers of the cortex. These neurons are specific to mammals and play a critical role in modulating the brain's various functions including sensory perception, motor commands, spatial reasoning, conscious thought, and language.\nFunctionally, L6b glutamatergic cortical neurons are heavily involved in information processing and transmission. Using glutamate as its primary neurotransmitter, these neurons can excite or stimulate other neurons, contributing to the overall activity of the cortical circuit. Their most notable role lies within their ability to communicate between cortical and subcortical structures, as the axons of L6b neurons extend out of the cortex and towards various subcortical areas, including the thalamus and cortex. Hence, these neurons can modulate the output of cortical information to these subcortical destinations.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1016/j.celrep.2020.02.044", xref="DOI:10.1016/j.neuron.2011.06.039", xref="DOI:10.1093/cercor/bhs254", xref="DOI:10.1093/cercor/bhy036", xref="DOI:10.3389/fncel.2023.1257803"} [Term] id: CL:4023039 name: amygdala excitatory neuron def: "Any neuron that has its soma located in some amygdala and is capable of some glutamate secretion, neurotransmission." [FBC:Autogenerated] comment: An excitatory neuron that is located in the amygdala. {xref="DOI:10.1101/2022.10.12.511898"} subset: human_reference_atlas subset: human_subset subset: mouse_subset is_a: CL:0000679 ! glutamatergic neuron is_a: CL:0012001 ! neuron of the forebrain intersection_of: CL:0000540 ! neuron intersection_of: RO:0002100 UBERON:0001876 ! has soma location amygdala intersection_of: RO:0002215 GO:0061535 ! capable of glutamate secretion, neurotransmission relationship: RO:0002100 UBERON:0001876 ! has soma location amygdala property_value: RO:0002175 NCBITaxon:9606 property_value: terms:contributor http://orcid.org/0000-0001-7258-9596 [Term] id: CL:4023040 name: L2/3-6 intratelencephalic projecting glutamatergic neuron def: "An intratelencephalic-projecting glutamatergic neuron with a soma found in cortical layers L2/3-6." [https://cellxgene.cziscience.com/e/c3aa4f95-7a18-4a7d-8dd8-ca324d714363.cxg/, PMID:34616075] subset: BDS_subset subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "L2/3-6 IT projecting neuron" EXACT [] is_a: CL:4023008 ! intratelencephalic-projecting glutamatergic cortical neuron property_value: IAO:0000028 "L2/3-6 IT glut" xsd:string property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_4023040" xsd:string {name="L2/3-6 intratelencephalic projecting glutamatergic neuron on CELLxGENE CellGuide"} property_value: terms:contributor https://orcid.org/0000-0001-7258-9596 property_value: terms:description "The L2/3-6 intratelencephalic projecting glutamatergic cortical neurons, often referred to by the shorthand L2/3-6 IT neurons, are essential variants of the most numerous types of excitatory neurons in the cerebral cortex. These neurons are found in layers 2, 3 to 6 of the cerebral cortex and are specifically classified under the glutamatergic neurons due to their ability to release the neurotransmitter. Therefore, they are primarily involved in producing excitatory responses, which serve as a significant component in the intricate pathways of neuronal communication and information processing within the brain.\nThese L2/3-6 IT neurons project intratelencephalically, implying that their axons interconnect regions within the cerebral hemispheres or between the two hemispheres, particularly to other cortical areas, the striatum, and the claustrum. This feature aids in vital brain functions such as perception, cognition, voluntary motor control, and learning. Importantly, these neurons possess a characteristic pyramidal morphology, which endows them with a high degree of connectivity to other neurons - thereby playing a crucial role in the formation and function of neural networks.\nEach specific cortical layer's glutamatergic neuron subtype bears a different function; for instance, neurons in the upper layers (L2/3) generally project to other cortical areas, ultimately assisting in the integration of sensory and motor information across diverse cortical regions. Conversely, the deeper layer neurons (L6) are associated with the modulation of thalamo-cortical input and output, in addition to projecting to the thalamus, reinforcing the complexity and bilateral communication within the cerebral cortex. Thus, the L2/3-6 intratelencephalic projecting glutamatergic cortical neuron, beyond its role as an excitatory neuron, critically influences a myriad of higher brain functions, reinforcing its importance in studying neurological processes and disorders.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1016/j.neuron.2018.10.032", xref="DOI:10.1038/nn.3917", xref="DOI:10.1038/nrn3469", xref="DOI:10.1038/s41586-021-03813-8", xref="DOI:10.1523/JNEUROSCI.0150-18.2018"} [Term] id: CL:4023041 name: L5 extratelencephalic projecting glutamatergic cortical neuron def: "A transcriptomically distinct glutamatergic neuron, with a soma found in the deeper portion of L5, that has long-range axonal projections including deep subcortical targets outside of the telencephalon and, in some cases, the spinal cord. While the L5 ET neuron projections are not limited to ET targets, they are clearly differentiated from the neuron subclasses whose projections are constrained to intratelencephalic (IT) targets. L5 ET neurons are generally the largest excitatory cortical neurons, typically having a thick apical dendrite with a prominent dendritic tuft in layer 1 and displaying burst-firing physiological characteristics." [https://cellxgene.cziscience.com/e/d01c9dff-abd1-4825-bf30-2eb2ba74597e.cxg/, PMID:34616075, PMID:37824655] comment: The marker set CHST8, POU3F1 can identify the Human cell type L5 extratelencephalic projecting glutamatergic cortical neuron in the neocortex with a confidence of 0.815891473 (NS-Forest FBeta value). {xref="https://doi.org/10.5281/zenodo.11165918"} subset: BDS_subset subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "burst-firing layer 5 neuron" EXACT [DOI:10.3389/fncel.2011.00001] synonym: "L5b neuron" RELATED OMO:0003000 [DOI:10.1016/j.neuron.2011.07.029] synonym: "pyramidal tract (PT) neuron" NARROW [DOI:10.1038/nrn3469] synonym: "Pyramidal tract-like (PT-l)" EXACT [PMID:31626774] {comment="pyramidal tract-like is used because, unlike pyramidal tract neurons in the motor cortex, neurons in the structures like the auditory cortex do not project to the spinal cord."} synonym: "subcerebral projection (SCPN) neuron" BROAD [DOI:10.1016/j.neuron.2005.08.030] synonym: "thick-tufted layer 5 (TTL5) pyramidal neuron" EXACT [DOI:10.3389/fncel.2015.00233] is_a: CL:4023009 ! extratelencephalic-projecting glutamatergic cortical neuron is_a: CL:4023111 ! cerebral cortex pyramidal neuron intersection_of: CL:4023009 ! extratelencephalic-projecting glutamatergic cortical neuron intersection_of: RO:0002100 UBERON:0005394 ! has soma location cortical layer V relationship: RO:0002100 UBERON:0005394 ! has soma location cortical layer V relationship: RO:0015004 CLM:1000067 ! has characterizing marker set NS forest marker set of L5 extratelencephalic projecting glutamatergic cortical neuron (Human neocortex). property_value: IAO:0000028 "L5 ET glut" xsd:string property_value: RO:0002175 NCBITaxon:9606 property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_4023041" xsd:string {name="L5 extratelencephalic projecting glutamatergic cortical neuron on CELLxGENE CellGuide"} property_value: terms:contributor https://orcid.org/0000-0001-7258-9596 property_value: terms:description "The L5 extratelencephalic projecting glutamatergic cortical neuron is a highly specialized neuron located in layer 5 (L5) of the cerebral cortex. The cerebral cortex, the outermost shell of the brain, is divided into six layers based on the types of neurons they contain and the functions they perform. L5 is known for its characteristic large pyramidal neurons, among which L5 extratelencephalic projecting glutamatergic cortical neurons reside.\nFunctionally, the primary role of the L5 extratelencephalic projecting glutamatergic cortical neuron is to send signals from the cerebral cortex to other parts of the brain or body apart from the telencephalon - the largest part of the brain that encompasses both cerebral hemispheres. These neurons accomplish this task through their long axons that form connections or synapses with neurons in other subcortical regions. Notably, these neurons are glutamatergic, meaning they release the neurotransmitter glutamate, which is crucial for signaling in the brain as it is the primary excitatory neurotransmitter and plays a crucial role in neural plasticity, learning, and memory.\nThe L5 extratelencephalic projecting glutamatergic cortical neuron is pivotal in carrying out complex motor activities as the signals they transmit are often directed to areas of the brain responsible for the initiation and modulation of motor functions, such as the spinal cord or the brainstem. Alterations in their structure or function can lead to various neurological disorders like autism, epilepsy, and schizophrenia.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1016/j.neuron.2021.08.030", xref="DOI:10.1038/s41467-020-14952-3", xref="DOI:10.1093/cercor/bhx012", xref="DOI:10.1523/JNEUROSCI.0150-18.2018", xref="DOI:10.3389/fnsyn.2022.1006773"} [Term] id: CL:4023042 name: L6 corticothalamic-projecting glutamatergic cortical neuron def: "A transcriptomically distinct corticothalamic-projecting neuron with a soma found in cortical layer 6." [https://cellxgene.cziscience.com/e/d01c9dff-abd1-4825-bf30-2eb2ba74597e.cxg/, PMID:34616075, PMID:37824655] comment: The marker set SEMA5B, ADAMTSL1, SULF1 can identify the Human cell type L6 corticothalamic-projecting glutamatergic cortical neuron in the neocortex with a confidence of 0.631898455 (NS-Forest FBeta value). {xref="https://doi.org/10.5281/zenodo.11165918"} subset: BDS_subset subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "L6 CT" EXACT [PMID:28625486, PMID:34616075] is_a: CL:4023013 ! corticothalamic-projecting glutamatergic cortical neuron intersection_of: CL:4023013 ! corticothalamic-projecting glutamatergic cortical neuron intersection_of: RO:0002100 UBERON:0005395 ! has soma location cortical layer VI relationship: RO:0002100 UBERON:0005395 ! has soma location cortical layer VI relationship: RO:0013001 UBERON:0010225 ! has synaptic IO in region thalamic complex relationship: RO:0015004 CLM:1000070 ! has characterizing marker set NS forest marker set of L6 corticothalamic-projecting glutamatergic cortical neuron (Human neocortex). property_value: IAO:0000028 "L6 CT glut" xsd:string property_value: RO:0002175 NCBITaxon:9606 property_value: terms:contributor https://orcid.org/0000-0001-7258-9596 [Term] id: CL:4023043 name: L5/6 near-projecting glutamatergic neuron of the primary motor cortex def: "A transcriptomically distinct near-projecting glutamatergic neuron with a soma found in layer 5/6 of the primary motor cortex. The standard transcriptomic reference data for this cell type can be found on the CellxGene census under the collection: 'Transcriptomic cytoarchitecture reveals principles of human neocortex organization', dataset: 'Supercluster: Deep layer (non-IT) excitatory neurons', Author Categories: 'CrossArea_subclass', cluster L5/6 NP." [https://cellxgene.cziscience.com/e/d01c9dff-abd1-4825-bf30-2eb2ba74597e.cxg/, PMID:31209381, PMID:34616075] subset: BDS_subset subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "L5/6 NP M1" EXACT [] synonym: "L5/6 NP MOp" EXACT [] xref: ILX:0770161 is_a: CL:4030067 ! L5/6 near-projecting glutamatergic neuron intersection_of: CL:4030067 ! L5/6 near-projecting glutamatergic neuron intersection_of: RO:0002100 UBERON:0001384 ! has soma location primary motor cortex relationship: RO:0002100 UBERON:0001384 ! has soma location primary motor cortex property_value: IAO:0000028 "L5/6 NP glut MOp" xsd:string property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_4023043" xsd:string {name="L5/6 near-projecting glutamatergic neuron of the primary motor cortex on CELLxGENE CellGuide"} property_value: terms:contributor https://orcid.org/0000-0001-7258-9596 property_value: terms:description "The L5/6 near-projecting glutamatergic neuron of the primary motor cortex, also known as the M1 layer 5/6 intratelencephalic pyramidal cell, is a subcategory of excitatory neurons primarily found in layers 5 and 6 of the primary motor cortex (M1), an area of the cerebrum responsible for executing voluntary motor functions. The term “glutamatergic” refers to these neurons releasing the neurotransmitter glutamate, which is a major excitatory neurotransmitter in the mammalian central nervous system. This function contributes to the propagation of nerve signals, playing a crucial role in learning and memory procedures.\nThese specialized neurons project close to their site of origin, specifically within the telencephalon or the largest previous division of the forebrain. These near projections are primarily involved in forming intratelencephalic connections. This particular characteristic distinguishes them from the long-range projecting neurons, which can bridge distant regions of the brain.\nFunctionally, the L5/6 near-projecting glutamatergic neurons play important roles in various aspects of cognitive performances, including motor control, decision making, and sensory processing. Studies have implicated these neurons in action selection and execution, due to their powerful excitatory influence on other neurons within the motor cortex and other parts of the telencephalon. Additionally, the near-projecting neurons play a significant role in the modulation of local cortical circuit dynamics, through their intra-cortical and cortico-striatal projections, further influencing both motor and cognitive functions.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1038/s41586-018-0642-9", xref="DOI:10.1523/JNEUROSCI.0150-18.2018", xref="DOI:10.1523/JNEUROSCI.0428-23.2023", xref="DOI:10.1523/JNEUROSCI.1188-17.2017"} [Term] id: CL:4023044 name: non-medulla, extratelencephalic-projecting glutamatergic neuron of the primary motor cortex def: "An extratelencephalic-projecting glutamatergic neuron located in layer 5b of the primary motor cortex that does not project to the medulla. Non-MY ET cells are large, big-tufted cells with the apical dendrite often bifurcating close to the soma, suggesting they are corticospinal cells. Non-MY ET cells have bigger hyperpolarization sag, lower input resistance, and smaller AP width, compared to L5 IT neurons." [DOI:10.1101/2020.10.19.343129, PMID:24137110, PMID:9236245] subset: BDS_subset subset: human_subset subset: mouse_subset synonym: "non-MY ET M1" EXACT [] synonym: "non-MY ET MOp (Mus)" EXACT [] is_a: CL:2000049 ! primary motor cortex pyramidal cell is_a: CL:4023041 ! L5 extratelencephalic projecting glutamatergic cortical neuron property_value: IAO:0000028 "non-MY ET glut MOp" xsd:string property_value: terms:contributor https://orcid.org/0000-0001-7258-9596 [Term] id: CL:4023045 name: medulla-projecting glutamatergic neuron of the primary motor cortex def: "An extratelencephalic-projecting glutamatergic neuron located in layer 5b of the primary motor cortex that projects to the medulla. MY ET cells are large, big-tufted cells with the apical dendrite often bifurcating close to the soma, suggesting they are corticospinal cells. MY ET cells have bigger hyperpolarization sag, lower input resistance, and smaller AP width, compared to L5 IT neurons." [DOI:10.1101/2020.10.19.343129, PMID:24137110, PMID:9236245] subset: BDS_subset subset: human_subset subset: mouse_subset synonym: "medulla-projecting extratelencephalic-projecting glutamatergic neuron of the primary motor cortex" EXACT [] synonym: "MY ET M1" EXACT [] synonym: "MY ET MOp" EXACT [] is_a: BFO:0000002 is_a: CL:2000049 ! primary motor cortex pyramidal cell is_a: CL:4023041 ! L5 extratelencephalic projecting glutamatergic cortical neuron relationship: RO:0000053 PATO:0070031 ! has characteristic corticomedulla projecting relationship: RO:0013001 UBERON:0001896 ! has synaptic IO in region medulla oblongata property_value: IAO:0000028 "MY ET glut MOp" xsd:string property_value: terms:contributor https://orcid.org/0000-0001-7258-9596 [Term] id: CL:4023046 name: L6b glutamatergic neuron of the primary motor cortex def: "An excitatory glutamatergic neuron transcriptomically related to the CT subclass, with a soma preferentially located in the bottom of L6 of the primary motor cortex." [PMID:33184512] comment: The marker set CCN2, ROS1 can identify the Human cell type L6b glutamatergic neuron of the primary motor cortex in the neocortex with a confidence of 0.819940964 (NS-Forest FBeta value). {xref="https://doi.org/10.5281/zenodo.11165918"} subset: BDS_subset subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "L6b subplate glutamatergic neuron of the primary motor cortex" EXACT [] is_a: CL:4023038 ! L6b glutamatergic cortical neuron relationship: RO:0002100 UBERON:0001384 ! has soma location primary motor cortex relationship: RO:0015004 CLM:1000073 ! has characterizing marker set NS forest marker set of L6b glutamatergic neuron of the primary motor cortex (Human neocortex). property_value: IAO:0000028 "L6b subplate glut" xsd:string property_value: RO:0002175 NCBITaxon:9606 property_value: terms:contributor https://orcid.org/0000-0001-7258-9596 [Term] id: CL:4023047 name: L2/3 intratelencephalic projecting glutamatergic neuron of the primary motor cortex def: "An intratelencephalic-projecting glutamatergic neuron with a soma found in cortical layer 2/3 of the primary motor cortex." [PMID:34616075] subset: BDS_subset subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "L2/3 IT M1" EXACT [PMID:34616075] synonym: "L2/3 IT MOp" EXACT [PMID:34616075] is_a: CL:4030059 ! L2/3 intratelencephalic projecting glutamatergic neuron intersection_of: CL:4030059 ! L2/3 intratelencephalic projecting glutamatergic neuron intersection_of: RO:0002100 UBERON:0001384 ! has soma location primary motor cortex relationship: RO:0002100 UBERON:0001384 ! has soma location primary motor cortex property_value: IAO:0000028 "L2/3 IT glut MOp" xsd:string property_value: terms:contributor https://orcid.org/0000-0001-7258-9596 [Term] id: CL:4023048 name: L4/5 intratelencephalic projecting glutamatergic neuron of the primary motor cortex def: "An intratelencephalic-projecting glutamatergic with a soma located in upper L5 of the primary motor cortex. These cells have thin untufted apical dendrites." [PMID:33184512] subset: BDS_subset subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "L4/5 IT M1" EXACT [] synonym: "L4/5 IT MOp" EXACT [] xref: ILX:0770174 is_a: CL:4030062 ! L4/5 intratelencephalic projecting glutamatergic neuron intersection_of: CL:4030062 ! L4/5 intratelencephalic projecting glutamatergic neuron intersection_of: RO:0002100 UBERON:0001384 ! has soma location primary motor cortex relationship: RO:0002100 UBERON:0001384 ! has soma location primary motor cortex property_value: IAO:0000028 "L4/5 IT glut MOp" xsd:string property_value: terms:contributor https://orcid.org/0000-0001-7258-9596 [Term] id: CL:4023049 name: L5 intratelencephalic projecting glutamatergic neuron of the primary motor cortex def: "An intratelencephalic-projecting glutamatergic neuron with a soma found in L5 of the primary motor cortex." [PMID:33184512] subset: BDS_subset subset: human_subset subset: mouse_subset synonym: "L5 IT M1" EXACT [] synonym: "L5 IT MOp" EXACT [] xref: ILX:0770157 is_a: CL:4030064 ! L5 intratelencephalic projecting glutamatergic neuron intersection_of: CL:4030064 ! L5 intratelencephalic projecting glutamatergic neuron intersection_of: RO:0002100 UBERON:0001384 ! has soma location primary motor cortex relationship: RO:0002100 UBERON:0001384 ! has soma location primary motor cortex property_value: IAO:0000028 "L5 IT glut MOp" xsd:string property_value: terms:contributor https://orcid.org/0000-0001-7258-9596 [Term] id: CL:4023050 name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex def: "An intratelencephalic-projecting glutamatergic neuron with a soma found in L6 of the primary motor cortex. These cells are short untufted pyramidal cells, which could be stellate or inverted." [PMID:33184512, PMID:34616063, PMID:34616075, PMID:9236245] subset: BDS_subset subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "L6 IT M1" EXACT [] synonym: "L6 IT MOp" EXACT [] xref: ILX:0770158 is_a: CL:2000049 ! primary motor cortex pyramidal cell is_a: CL:4023095 ! untufted pyramidal neuron is_a: CL:4030065 ! L6 intratelencephalic projecting glutamatergic neuron intersection_of: CL:4030065 ! L6 intratelencephalic projecting glutamatergic neuron intersection_of: RO:0002100 UBERON:0001384 ! has soma location primary motor cortex property_value: IAO:0000028 "L6 IT glut MOp" xsd:string property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_4023050" xsd:string {name="L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex on CELLxGENE CellGuide"} property_value: terms:contributor https://orcid.org/0000-0001-7258-9596 property_value: terms:description "The L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex is a specialized neuron situated in layer 6 (L6) of the primary motor cortex, a region of the brain that enables voluntary muscle control, planning of movements, and execution of complex motor tasks. The word 'intratelencephalic' denotes its pattern of connectivity, projecting within the telencephalon, the anterior part of the brain which contains both the cerebral cortex and subcortical structures. These neurons are classified as glutamatergic, as they use glutamate as their main excitatory neurotransmitter. Glutamate is a key player in mediating excitatory synapses in the mammalian central nervous system. Morphologically, these untufted neurons have short apical dendrites and with fewer branches compared to other neurons.\nThe L6 intratelencephalic projecting neurons play a critical role in motor function and cognitive processes. By releasing glutamate, they stimulate other neurons to which it is connected, directly impacting processes of memory, learning, and synaptic plasticity. The glutamatergic neurotransmission from these neurons shapes the output of the intrinsic cortical microcircuitry and its interaction with other brain regions, subsequently influencing the timing, coordination, and strength of motor commands.\nFunctionally, the L6 intratelencephalic projecting neurons integrate and transmit the afferent signals coming from the cortical layers above, particularly from the apical dendrites of the pyramidal neurons in layers 2 and 3. As the deepest layer in the six-layered neocortex, L6 contributes extensively to the feedback circuitry, both locally and across distal cortical areas. Despite the limited knowledge available on specific L6 neuron subypes owing to their heterogeneity, it is clear that L6 intratelencephalic projecting glutamatergic neurons serve as crucial components in the cortex's role as the canonical center for sensorimotor integration and cognition.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1093/cercor/bhs254", xref="DOI:10.1523/JNEUROSCI.0150-18.2018", xref="DOI:10.1523/JNEUROSCI.2254-10.2010", xref="DOI:10.3389/fnana.2010.00013", xref="DOI:10.3389/neuro.04.003.2010"} [Term] id: CL:4023051 name: vascular leptomeningeal cell def: "A transcriptomically distinct type of mesothelial fibroblast that is derived from the neural crest, is localized on blood vessels, and is a key component of the pia and arachnoid membranes surrounding the brain. The standard transcriptomic reference data for this cell type can be found on the CellxGene census under the collection: 'Transcriptomic cytoarchitecture reveals principles of human neocortex organization', dataset: 'Supercluster: Non-neuronal cells', Author Categories: 'CrossArea_subclass', clusters VLMC." [https://cellxgene.cziscience.com/e/5346f9c6-755e-4336-94cc-38706ec00c2f.cxg/, PMID:27284195, PMID:29443965, PMID:30096314, PMID:37824655] subset: BDS_subset subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "VLMC" EXACT [] xref: ILX:0770143 is_a: CL:4023058 ! mesothelial fibroblast of the leptomeninx relationship: RO:0002202 CL:0011012 ! develops from neural crest cell property_value: terms:contributor https://orcid.org/0000-0001-7258-9596 [Term] id: CL:4023052 name: Betz upper motor neuron def: "A Betz cell that synapses with lower motor neurons directly." [DOI:10.1101/2020.03.31.016972, PMID:18558853, PMID:28751609] subset: human_subset subset: mouse_subset is_a: BFO:0000002 is_a: CL:0008049 ! Betz cell relationship: RO:0002120 CL:0008039 ! synapsed to lower motor neuron property_value: RO:0002175 NCBITaxon:9606 property_value: terms:contributor https://orcid.org/0000-0001-7258-9596 [Term] id: CL:4023053 name: spinal interneuron synapsing Betz cell def: "A Betz cell that syanpses with spinal interneurons." [DOI:10.1101/2020.03.31.016972, PMID:18558853] subset: human_subset subset: mouse_subset is_a: CL:0008049 ! Betz cell relationship: RO:0002120 CL:0005000 ! synapsed to spinal cord interneuron property_value: RO:0002175 NCBITaxon:9685 property_value: RO:0002175 NCBITaxon:9989 property_value: terms:contributor https://orcid.org/0000-0001-7258-9596 [Term] id: CL:4023054 name: mesothelial fibroblast def: "A mesothelial cell that has undergone mesothelial-to-mesenchymal transition (MMT) to become a fibroblast cell." [PMID:26106328] subset: cellxgene_subset subset: human_subset subset: mouse_subset is_a: CL:0000057 ! fibroblast relationship: RO:0002202 CL:0000077 ! develops from mesothelial cell property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_4023054" xsd:string {name="mesothelial fibroblast on CELLxGENE CellGuide"} property_value: terms:contributor https://orcid.org/0000-0001-7258-9596 property_value: terms:description "Mesothelial fibroblasts primarily originate from mesothelial cells, which form a protective layer known as mesothelium covering certain internal organs such as the heart, lungs, and abdominal cavity. Functionally, mesothelial fibroblasts excel in their capacity to synthesize and secrete extracellular matrix (ECM), a complex network of proteins that provides structural and biochemical support to surrounding cells. The ECM produced by mesothelial fibroblasts acts as a scaffold for tissue growth and remodeling, which is particularly important in wound healing and tissue repair processes. Additionally, these cells participate in immune response modulation within the mesothelium layer, interacting with various immune cells and mediating inflammatory processes. However, in certain diseases like fibrosis, these cells can excessively proliferate and produce ECM, leading to tissue thickening and organ malfunction. They also play a role in the progression of mesothelioma, a type of cancer that affects the mesothelium.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1016/j.ccell.2022.04.011", xref="DOI:10.1016/j.cell.2018.06.021", xref="DOI:10.1038/s42003-018-0180-x", xref="DOI:10.3389/fphar.2015.00113", xref="DOI:10.3747/pdi.2014.00188"} [Term] id: CL:4023055 name: corticothalamic VAL/VM projecting glutamatergic neuron of the primary motor cortex def: "A corticothalamic-projecting glutamatergic neuron that is located in L6 and lower L5 of the primary motor cortex, with a pyramidal morphology and mostly untufted apical dendrites terminating in midcortical layers. CT VAL/VM (ventroanterior-ventrolateral complex/ventromedial nucleus) cells have a near tonic firing pattern and are distinguished from L6 IT neurons by a lower inter-spike interval adaptation index." [PMID:20556241, PMID:9236245] comment: The assertion of this cell type under L6 CT is due to the ambiguity of lower L5 and L6. subset: BDS_subset subset: human_subset subset: mouse_subset synonym: "CT VAL/VM M1" EXACT [] synonym: "CT VAL/VM MOp" EXACT [] is_a: CL:2000049 ! primary motor cortex pyramidal cell is_a: CL:4023042 ! L6 corticothalamic-projecting glutamatergic cortical neuron is_a: CL:4023095 ! untufted pyramidal neuron property_value: IAO:0000028 "CT VAL/VM glut MOp" xsd:string property_value: terms:contributor https://orcid.org/0000-0001-7258-9596 [Term] id: CL:4023056 name: vascular leptomeningeal cell (Mmus) def: "A type of mouse mesothelial fibroblast that is derived from the neural crest, is localized on blood vessels, and is a key component of the pia and arachnoid membranes surrounding the brain." [PMID:30096314] subset: BDS_subset subset: cellxgene_subset subset: mouse_subset synonym: "VLMC (Mus musculus)" EXACT [] is_a: CL:4023051 ! vascular leptomeningeal cell relationship: RO:0002162 NCBITaxon:10090 ! in taxon Mus musculus relationship: RO:0002292 PR:P11087 {xref="PMID:30096314"} ! expresses collagen alpha-1(I) chain (mouse) relationship: RO:0002292 PR:P26618 {xref="PMID:30096314"} ! expresses platelet-derived growth factor receptor alpha (mouse) relationship: RO:0002292 PR:P51885 {xref="PMID:30096314"} ! expresses lumican (mouse) property_value: terms:contributor https://orcid.org/0000-0001-7258-9596 [Term] id: CL:4023057 name: cerebellar inhibitory GABAergic interneuron def: "A GABAergic interneuron whose soma is located in the cerebellar cortex." [DOI:10.1101/2022.10.12.511898] subset: human_reference_atlas subset: human_subset subset: mouse_subset is_a: CL:0011005 ! GABAergic interneuron is_a: CL:1001611 ! cerebellar neuron intersection_of: CL:0011005 ! GABAergic interneuron intersection_of: RO:0002100 UBERON:0002129 ! has soma location cerebellar cortex relationship: RO:0002100 UBERON:0002129 ! has soma location cerebellar cortex property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "cerebellar inhibitory GABAergic interneuron" xsd:string property_value: terms:contributor http://orcid.org/0000-0001-7258-9596 [Term] id: CL:4023058 name: mesothelial fibroblast of the leptomeninx def: "A mesothelial fibroblast found in the leptomeninx." [] subset: human_subset subset: mouse_subset is_a: CL:0002319 ! neural cell is_a: CL:4023054 ! mesothelial fibroblast intersection_of: CL:4023054 ! mesothelial fibroblast intersection_of: BFO:0000050 UBERON:0000391 ! part of leptomeninx relationship: BFO:0000050 UBERON:0000391 ! part of leptomeninx property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_4023058" xsd:string {name="mesothelial fibroblast of the leptomeninx on CELLxGENE CellGuide"} property_value: terms:contributor https://orcid.org/0000-0001-7258-9596 property_value: terms:description "The mesothelial fibroblast of the leptomeninx is a specialized type of cell typically located in the leptomeninx or leptomeninges, a portion of meninges consisting of the arachnoid mater and pia mater. The meninges are protective layers surrounding the brain and spinal cord, with the leptomeninx being the delicate inner two layers. These fibroblasts play a critical role within the central nervous system, contributing to the structure, maintenance, and overall functionality of the leptomeninx.\nGenerally, mesothelial fibroblasts are characterized by their spindle-shaped morphology and their function, which pertains primarily to the production of the extracellular matrix (ECM). The ECM provides structural support, contributes to tissue repair, and influences various cellular activities such as growth and differentiation. Mesothelial fibroblasts are highly involved in collagen production, which is an integral protein in the ECM. Consequently, these cells play a vital role in physical and biological scaffolding and in maintaining the stability and resilience of the leptomeninges.\nUnder pathological conditions, mesothelial fibroblasts of the leptomeninx may undergo changes and contribute to disease progression. For example, in cases of meningitis, these cells can mount an inflammatory response to help fight off the infection. When the ECM is damaged due to trauma or disease, mesothelial fibroblasts of the leptomeninx can also become activated, migrating to the site of injury to aid in tissue repair and remodeling. Therefore, the mesothelial fibroblasts of the leptomeninx reflect a crucial multidimensional role in both normal physiological and disease-related processes within the leptomeninges of the central nervous system.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1016/j.neuron.2023.09.002", xref="DOI:10.1126/science.adc8810", xref="DOI:10.1148/rg.230039", xref="DOI:10.1371/journal.pone.0080463", xref="DOI:10.3892/mmr.2016.5411"} [Term] id: CL:4023059 name: committed oligodendrocyte precursor def: "An oligodendrocyte precursor cell that is committed to differentiate." [PMID:32066987] comment: COPs are distinct from OPCs in that the lack expression of Pdgfra and Cspg4 and come out as distinct clusters in transcriptomic profiling. This is the reason that this term is not modelled as a subclassOf OPC but instead linked using develops_from. {xref="PMID:27284195"} subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "COP" EXACT OMO:0003000 [] synonym: "differentiation-committed oligodendrocyte precursor" EXACT [] is_a: CL:0000123 ! neuron associated cell (sensu Vertebrata) relationship: RO:0002202 CL:0002453 ! develops from oligodendrocyte precursor cell property_value: RO:0002175 NCBITaxon:9606 property_value: terms:contributor http://orcid.org/0000-0001-7258-9596 [Term] id: CL:4023060 name: hippocampal CA1-3 neuron def: "A neuron that has its soma located in CA1-3 of the hippocampus." [DOI:10.1101/2022.10.12.511898] subset: human_reference_atlas subset: human_subset subset: mouse_subset is_a: CL:0002608 ! hippocampal neuron relationship: RO:0002100 UBERON:0001954 ! has soma location Ammon's horn property_value: IAO:0000116 "It is unclear as to if the modelling of Ammon's horn includes CA4 (which could be considered part of the dentate gyrus) in Uberon, hence no equivalent class axiom was made." xsd:string property_value: RO:0002175 NCBITaxon:9606 property_value: terms:contributor http://orcid.org/0000-0001-7258-9596 [Term] id: CL:4023061 name: hippocampal CA4 neuron def: "A neuron that has its soma located in CA4 of the hippocampus." [DOI:10.1101/2022.10.12.511898] subset: human_reference_atlas subset: human_subset subset: mouse_subset is_a: CL:2000029 ! central nervous system neuron property_value: RO:0002175 NCBITaxon:9606 property_value: terms:contributor http://orcid.org/0000-0001-7258-9596 [Term] id: CL:4023062 name: dentate gyrus neuron def: "A neuron with its soma located in the dentate gyrus of the hippocampus." [] subset: human_reference_atlas subset: human_subset subset: mouse_subset is_a: CL:0002608 ! hippocampal neuron intersection_of: CL:0000540 ! neuron intersection_of: RO:0002100 UBERON:0001885 ! has soma location dentate gyrus of hippocampal formation relationship: RO:0002100 UBERON:0001885 ! has soma location dentate gyrus of hippocampal formation property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "dentate gyrus neuron" xsd:string property_value: terms:contributor http://orcid.org/0000-0001-7258-9596 [Term] id: CL:4023063 name: medial ganglionic eminence derived interneuron def: "An interneuron that is derived from the medial ganglionic eminence." [DOI:10.1101/2022.10.12.511898] subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "MGE interneuron" EXACT [] is_a: BFO:0000002 is_a: CL:0000099 ! interneuron intersection_of: CL:0000099 ! interneuron intersection_of: RO:0002202 UBERON:0004024 ! develops from medial ganglionic eminence relationship: RO:0002202 UBERON:0004024 ! develops from medial ganglionic eminence property_value: IAO:0000028 "MGE interneuron" xsd:string property_value: RO:0002175 NCBITaxon:9606 property_value: terms:contributor http://orcid.org/0000-0001-7258-9596 [Term] id: CL:4023064 name: caudal ganglionic eminence derived interneuron def: "An interneuron that is derived from the caudal ganglionic eminence." [PMID:20130169, PMID:37824655, PMID:37824663] subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "caudal ganglionic eminence derived GABAergic interneuron" EXACT [PMID:20130169] synonym: "CGE interneuron" RELATED OMO:0003000 [PMID:20130169] synonym: "CGE interneuron" RELATED OMO:0003000 [PMID:37824663] synonym: "CGE-derived cell" RELATED OMO:0003000 [PMID:27034423] synonym: "CGE-derived GABAergic IN" RELATED OMO:0003000 [PMID:27034423] synonym: "CGE-derived interneuron" RELATED OMO:0003000 [PMID:20130169, PMID:37824655] is_a: CL:0010011 ! cerebral cortex GABAergic interneuron is_a: CL:4042039 ! caudal ganglionic eminence derived neuron intersection_of: CL:0000099 ! interneuron intersection_of: RO:0002202 UBERON:0004026 ! develops from caudal ganglionic eminence property_value: IAO:0000028 "CGE interneuron" xsd:string property_value: RO:0002175 NCBITaxon:9606 property_value: terms:contributor http://orcid.org/0000-0001-7258-9596 [Term] id: CL:4023065 name: meis2 expressing cortical GABAergic cell def: "A GABAergic cell located in the cerebral cortex that expresses meis2." [PMID:33372656] subset: BDS_subset subset: cellxgene_subset subset: human_subset subset: mouse_subset is_a: BFO:0000002 is_a: CL:0000617 ! GABAergic neuron is_a: CL:0010012 ! cerebral cortex neuron relationship: RO:0002292 PR:000010317 ! expresses homeobox protein Meis2 property_value: IAO:0000028 "meis2 GABA" xsd:string property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_4023065" xsd:string {name="meis2 expressing cortical GABAergic cell on CELLxGENE CellGuide"} property_value: terms:contributor https://orcid.org/0000-0001-7258-9596 property_value: terms:description "The meis2 expressing cortical GABAergic cell is a unique and specialized type of neuron found within the complex architecture of the cerebral cortex. Specifically, these neurons originate from a region bordering the pallium and subpallium. Meis2 refers to the gene that codes for the Meis homeobox2 protein, which is a crucial transcription factor that regulates neural development. Most importantly, the GABAergic characteristic of these cells refers to their function in relation to the release of the neurotransmitter gamma-aminobutyric acid (GABA), which carries inhibitory signals to help maintain stable and controlled communication between neurons.\nOne of the essential roles that the meis2 expressing cortical GABAergic cell plays in the organism is in establishing a balance between excitation and inhibition in neuronal signaling. The primary neurotransmitter that this cell synthesizes and releases is GABA, the main inhibitory neurotransmitter in the mammalian central nervous system. It acts to reduce neuronal excitability and prevents over-firing of neurons, effectively preventing excessive neuronal activity that could lead to seizures or overstimulation. By countering excessive excitatory signals, GABAergic cells work to stabilize the intricate dynamics of the brain and maintain physiological homeostasis.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1016/j.stemcr.2018.03.010", xref="DOI:10.1038/ncomms14219", xref="DOI:10.1038/s41586-018-0654-5", xref="DOI:10.1038/s41598-022-21496-7", xref="DOI:10.1242/dev.200035"} [Term] id: CL:4023066 name: horizontal pyramidal neuron def: "A pyramidal neuron which has an apical tree which is oriented parallel to the pia. This is unlike typical pyramidal neurons which have its apical dendrite aligned vertically." [PMID:30715238] subset: BDS_subset subset: human_subset subset: mouse_subset is_a: CL:0000598 ! pyramidal neuron intersection_of: CL:0000540 ! neuron intersection_of: RO:0000053 PATO:0070016 ! has characteristic horizontal pyramidal morphology relationship: RO:0000053 PATO:0070016 ! has characteristic horizontal pyramidal morphology property_value: terms:contributor https://orcid.org/0000-0001-7258-9596 [Term] id: CL:4023067 name: obsolete Martinotti morphology L2/3 pvalb-like sst GABAergic cortical interneuron (Mus musculus) def: "OBSOLETE A L2/3 pvalb-like sst GABAergic cortical interneuron (Mus musculus) that has Martinotti morphology." [PMID:33184512] comment: Moved to PCL. Use PCL:1000004 instead. synonym: "Martinotti L2/3 PV-like SST (Mus)" EXACT [] property_value: IAO:0000233 https://github.com/obophenotype/brain_data_standards_ontologies/issues/231 property_value: terms:contributor https://orcid.org/0000-0001-7258-9596 is_obsolete: true replaced_by: PCL:1000004 [Term] id: CL:4023068 name: thalamic excitatory neuron def: "An excitatory neuron that has its soma located in the thalamic complex. This neuron type can be involved in a series of circuits related to sensory integration, motor integration, pain processing, social behaviour and reward response." [PMID:30083593, PMID:31196673, PMID:35278647, PMID:37163009, PMID:37824663, PMID:38739251] comment: Abnormalities in glutametergic neurons of the thalamic complex are associated with pathologies such as schizophrenia, colorectal visceral pain and Parkinson's disease. {xref="PMID:11532718", xref="PMID:30083593", xref="PMID:38739251"} subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset is_a: CL:0000679 ! glutamatergic neuron is_a: CL:0012001 ! neuron of the forebrain intersection_of: CL:0000540 ! neuron intersection_of: RO:0002100 UBERON:0010225 ! has soma location thalamic complex intersection_of: RO:0002215 GO:0061535 ! capable of glutamate secretion, neurotransmission relationship: RO:0002100 UBERON:0010225 ! has soma location thalamic complex property_value: RO:0002175 NCBITaxon:9606 property_value: terms:contributor http://orcid.org/0000-0001-7258-9596 [Term] id: CL:4023069 name: medial ganglionic eminence derived GABAergic interneuron def: "A GABAergic interneuron that develops from the medial ganglionic eminence and has migrated to the cerebral cortex." [PMID:12637172] subset: cellxgene_subset subset: human_subset subset: mouse_subset is_a: CL:0010011 ! cerebral cortex GABAergic interneuron is_a: CL:4023063 ! medial ganglionic eminence derived interneuron intersection_of: CL:0000099 ! interneuron intersection_of: RO:0002100 UBERON:0000956 ! has soma location cerebral cortex intersection_of: RO:0002202 UBERON:0004024 ! develops from medial ganglionic eminence intersection_of: RO:0002215 GO:0061534 ! capable of gamma-aminobutyric acid secretion, neurotransmission property_value: IAO:0000028 "MGE gaba interneuron" xsd:string property_value: terms:contributor https://orcid.org/0000-0001-7258-9596 [Term] id: CL:4023070 name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron def: "OBSOLETE. A GABAergic cortical interneuron that develops from the caudal ganglionic eminence and has migrated to the cerebral cortex." [PMID:20130169] comment: caudal ganglionic eminence derived GABAergic interneuron\nand caudal ganglionic eminence derived interneuron are the same cell type. \nThe two must be merged and one needs to be defined as obsolete. \nWe decided to deprecate the entity with the more specific term and redundant qualities \nin the label. See comments in issue 2357. synonym: "CGE cortical interneuron" EXACT [] property_value: IAO:0000028 "CGE gaba cortical interneuron" xsd:string property_value: IAO:0000233 https://github.com/obophenotype/cell-ontology/pull/2374 property_value: terms:contributor https://orcid.org/0000-0001-7258-9596 is_obsolete: true replaced_by: CL:4023064 [Term] id: CL:4023071 name: L5/6 cck GABAergic interneuron (Mmus) def: "A GABAergic cortical interneuron that expresses cck. L5/6 cck cells have soma found mainly in L5 and L6 and have large axonal arborization." [PMID:33184512] subset: BDS_subset subset: mouse_subset synonym: "L5/6 CCK (Mus musculus)" EXACT [] is_a: BFO:0000002 is_a: CL:0010011 ! cerebral cortex GABAergic interneuron relationship: RO:0002100 UBERON:8440002 ! has soma location cortical layer V/VI relationship: RO:0002162 NCBITaxon:10090 ! in taxon Mus musculus relationship: RO:0002292 PR:P09240 ! expresses cholecystokinin (mouse) property_value: IAO:0000028 "L5/6 cck interneuron (Mus)" xsd:string property_value: terms:contributor https://orcid.org/0000-0001-7258-9596 [Term] id: CL:4023072 name: brain vascular cell def: "A cell that is part of the brain vasculature." [DOI:10.1101/2022.10.12.511898] subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset is_a: CL:0002319 ! neural cell intersection_of: CL:0000000 ! cell intersection_of: BFO:0000050 UBERON:0008998 ! part of vasculature of brain relationship: BFO:0000050 UBERON:0008998 ! part of vasculature of brain property_value: RO:0002175 NCBITaxon:9606 property_value: terms:contributor http://orcid.org/0000-0001-7258-9596 [Term] id: CL:4023073 name: obsolete choroid plexus cell def: "OBSOLETE. A cell that is part of the choroid plexus." [DOI:10.1101/2022.10.12.511898] property_value: IAO:0000233 https://github.com/obophenotype/cell-ontology/issues/2043 property_value: terms:contributor http://orcid.org/0000-0001-7258-9596 is_obsolete: true replaced_by: CL:0000706 [Term] id: CL:4023074 name: mammillary body neuron def: "A neuron that has its soma located in the mammillary body." [DOI:10.1101/2022.10.12.511898] subset: human_reference_atlas subset: human_subset subset: mouse_subset is_a: CL:0012001 ! neuron of the forebrain intersection_of: CL:0000540 ! neuron intersection_of: RO:0002100 UBERON:0002206 ! has soma location mammillary body relationship: RO:0002100 UBERON:0002206 ! has soma location mammillary body property_value: RO:0002175 NCBITaxon:9606 property_value: terms:contributor http://orcid.org/0000-0001-7258-9596 [Term] id: CL:4023075 name: L6 th sst GABAergic interneuron (Mmus) def: "A sst GABAergic cortical interneuron found in L6 that expresses tyrosine hydroxylase. L6 Th+ SST cells have mostly local axonal arborization within L6." [PMID:22357664] subset: BDS_subset subset: mouse_subset synonym: "L6 Th+ SST (Mus musculus)" EXACT [] synonym: "L6 tyrosine hydroxylase positive sst expressing GABAergic cortical interneuron (Mus musculus)" EXACT [] is_a: BFO:0000002 is_a: CL:0010011 ! cerebral cortex GABAergic interneuron relationship: RO:0002100 UBERON:0005395 ! has soma location cortical layer VI relationship: RO:0002162 NCBITaxon:10090 ! in taxon Mus musculus relationship: RO:0002292 PR:P24529 ! expresses tyrosine 3-monooxygenase (mouse) relationship: RO:0002292 PR:P60041 ! expresses somatostatin (mouse) property_value: IAO:0000028 "L6 th sst interneuron (Mus)" xsd:string property_value: terms:contributor https://orcid.org/0000-0001-7258-9596 [Term] id: CL:4023076 name: Martinotti neuron def: "An interneuron that has Martinotti morphology. These interneurons are scattered throughout various layers of the cerebral cortex, sending their axons up to the cortical layer I where they form axonal arborization." [WikipediaVersioned:Martinotti_cell&oldid=9947732] subset: BDS_subset subset: human_subset subset: mouse_subset xref: ILX:0107375 xref: NIFEXT:55 is_a: CL:0011005 ! GABAergic interneuron intersection_of: CL:0000099 ! interneuron intersection_of: RO:0000053 PATO:0070007 ! has characteristic Martinotti morphology intersection_of: RO:0002215 GO:0061534 ! capable of gamma-aminobutyric acid secretion, neurotransmission relationship: RO:0000053 PATO:0070007 ! has characteristic Martinotti morphology property_value: terms:contributor https://orcid.org/0000-0001-7258-9596 [Term] id: CL:4023077 name: bitufted neuron def: "A type of interneuron that has two clusters of dendritic branches that originate directly from the soma and extend in opposite directions and axons that form a plexus which spreads widely. Compared to bipolar neurons, bitufted neurons have branching that occur close to the soma." [PMID:18568015] subset: BDS_subset subset: human_subset subset: mouse_subset xref: ILX:0777212 {IAO:0000116="Interlex cross reference refers specifically to Markram 2015 rat bitufted cell."} is_a: CL:0000099 ! interneuron intersection_of: CL:0000099 ! interneuron intersection_of: RO:0000053 PATO:0070012 ! has characteristic bitufted cell morphology relationship: RO:0000053 PATO:0070012 ! has characteristic bitufted cell morphology property_value: terms:contributor https://orcid.org/0000-0001-7258-9596 [Term] id: CL:4023078 name: obsolete basket morphology L2/3 pvalb-like sst GABAergic cortical interneuron (Mus musculus) def: "OBSOLETE A L2/3 pvalb-like sst GABAergic cortical interneuron (Mus musculus) that has basket morphology." [PMID:33184512] comment: Moved to PCL. Use PCL:1000003 instead. synonym: "basket L2/3 PV-like SST (Mus)" EXACT [] property_value: IAO:0000233 https://github.com/obophenotype/brain_data_standards_ontologies/issues/231 property_value: terms:contributor https://orcid.org/0000-0001-7258-9596 is_obsolete: true replaced_by: PCL:1000003 [Term] id: CL:4023079 name: midbrain-derived inhibitory neuron def: "A GABAergic inhibitory neuron that is derived from the midbrain." [DOI:10.1101/2022.10.12.511898] subset: human_reference_atlas subset: human_subset subset: mouse_subset is_a: CL:2000029 ! central nervous system neuron is_a: UBERON:0004121 ! ectoderm-derived structure intersection_of: CL:0000540 ! neuron intersection_of: RO:0002202 UBERON:0001891 ! develops from midbrain relationship: RO:0002202 UBERON:0001891 ! develops from midbrain property_value: RO:0002175 NCBITaxon:9606 property_value: terms:contributor http://orcid.org/0000-0001-7258-9596 [Term] id: CL:4023080 name: stellate L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (Mmus) def: "a L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex that has stellate pyramidal morphology." [PMID:9236245] subset: BDS_subset subset: human_subset subset: mouse_subset synonym: "stellate L6 IT MOp (Mus musculus)" EXACT [] is_a: CL:4023050 ! L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex is_a: CL:4023093 ! stellate pyramidal neuron property_value: IAO:0000028 "stellate L6 IT glut MOp" xsd:string property_value: terms:contributor https://orcid.org/0000-0001-7258-9596 [Term] id: CL:4023081 name: inverted L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (Mmus) def: "a L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex that has inverted pyramidal morphology." [PMID:9236245] subset: BDS_subset subset: human_subset subset: mouse_subset synonym: "inverted L6 IT MOp (Mus musculus)" EXACT [] is_a: CL:4023050 ! L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex is_a: CL:4023092 ! inverted pyramidal neuron property_value: IAO:0000028 "inverted L6 IT glut MOp" xsd:string property_value: terms:contributor https://orcid.org/0000-0001-7258-9596 [Term] id: CL:4023083 name: obsolete chandelier cell comment: Duplicate term subset: cellxgene_subset is_obsolete: true replaced_by: CL:4023036 [Term] id: CL:4023086 name: T Martinotti neuron def: "A Martinotti neuron that has axons that form a horizontal ramification, making it T-shaped." [doi:10.1016/b978-0-12-369497-3.10004-4] subset: BDS_subset subset: human_subset subset: mouse_subset synonym: "T-shaped Martinotti neuron" EXACT [] is_a: CL:4023076 ! Martinotti neuron intersection_of: CL:0000099 ! interneuron intersection_of: RO:0000053 PATO:0070008 ! has characteristic T Martinotti morphology intersection_of: RO:0002215 GO:0061534 ! capable of gamma-aminobutyric acid secretion, neurotransmission relationship: RO:0000053 PATO:0070008 ! has characteristic T Martinotti morphology property_value: terms:contributor https://orcid.org/0000-0001-7258-9596 [Term] id: CL:4023087 name: fan Martinotti neuron def: "A Martinotti neuron that has axons that form a fan-like plexus." [doi:10.1016/b978-0-12-369497-3.10004-4] subset: BDS_subset subset: human_subset subset: mouse_subset synonym: "fanning-out Martinotti neuron" EXACT [] is_a: CL:4023076 ! Martinotti neuron intersection_of: CL:0000099 ! interneuron intersection_of: RO:0000053 PATO:0070009 ! has characteristic fan Martinotti morphology intersection_of: RO:0002215 GO:0061534 ! capable of gamma-aminobutyric acid secretion, neurotransmission relationship: RO:0000053 PATO:0070009 ! has characteristic fan Martinotti morphology property_value: terms:contributor https://orcid.org/0000-0001-7258-9596 [Term] id: CL:4023088 name: large basket cell def: "A basket cell that is large, and typically ascends to give rise to many long horizontally and vertically projecting axon collaterals that traverse neighboring columns and can extend through all cortical layers." [PMID:11884355] subset: BDS_subset subset: human_subset subset: mouse_subset is_a: CL:2000086 ! neocortex basket cell intersection_of: CL:0000099 ! interneuron intersection_of: RO:0000053 PATO:0070004 ! has characteristic large basket cell morphology intersection_of: RO:0002100 UBERON:0001950 ! has soma location neocortex intersection_of: RO:0002215 GO:0061534 ! capable of gamma-aminobutyric acid secretion, neurotransmission relationship: RO:0000053 PATO:0070004 ! has characteristic large basket cell morphology property_value: terms:contributor https://orcid.org/0000-0001-7258-9596 [Term] id: CL:4023089 name: nest basket cell def: "A basket cell which has simpler dendritic arbors (compared to small or large basket cells), and an axonal plexus of intermediate density, composed of a few long, smooth axonal branches." [PMID:11884355] subset: BDS_subset subset: human_subset subset: mouse_subset is_a: CL:2000086 ! neocortex basket cell intersection_of: CL:0000099 ! interneuron intersection_of: RO:0000053 PATO:0070005 ! has characteristic nest basket cell morphology intersection_of: RO:0002100 UBERON:0001950 ! has soma location neocortex intersection_of: RO:0002215 GO:0061534 ! capable of gamma-aminobutyric acid secretion, neurotransmission relationship: RO:0000053 PATO:0070005 ! has characteristic nest basket cell morphology property_value: terms:contributor https://orcid.org/0000-0001-7258-9596 [Term] id: CL:4023090 name: small basket cell def: "A basket cell with axonal arbors composed of frequent, short, curvy axonal branches that tend to be near their somata and within the same layer." [PMID:11884355] subset: BDS_subset subset: human_subset subset: mouse_subset is_a: CL:2000086 ! neocortex basket cell intersection_of: CL:0000099 ! interneuron intersection_of: RO:0000053 PATO:0070003 ! has characteristic small basket cell morphology intersection_of: RO:0002100 UBERON:0001950 ! has soma location neocortex intersection_of: RO:0002215 GO:0061534 ! capable of gamma-aminobutyric acid secretion, neurotransmission relationship: RO:0000053 PATO:0070003 ! has characteristic small basket cell morphology property_value: terms:contributor https://orcid.org/0000-0001-7258-9596 [Term] id: CL:4023092 name: inverted pyramidal neuron def: "A pyramidal neuron which has an apical tree which is oriented towards the white matter." [PMID:30715238] subset: BDS_subset subset: human_subset subset: mouse_subset is_a: CL:0000598 ! pyramidal neuron intersection_of: CL:0000540 ! neuron intersection_of: RO:0000053 PATO:0070021 ! has characteristic inverted pyramidal morphology relationship: RO:0000053 PATO:0070021 ! has characteristic inverted pyramidal morphology property_value: terms:contributor https://orcid.org/0000-0001-7258-9596 [Term] id: CL:4023093 name: stellate pyramidal neuron def: "A pyramidal neuron which lacks a tuft formation but extends small radial distances forming a star-like shape." [PMID:30715238] subset: BDS_subset subset: human_subset subset: mouse_subset is_a: CL:0000598 ! pyramidal neuron intersection_of: CL:0000540 ! neuron intersection_of: RO:0000053 PATO:0070020 ! has characteristic stellate pyramidal morphology relationship: RO:0000053 PATO:0070020 ! has characteristic stellate pyramidal morphology property_value: terms:contributor https://orcid.org/0000-0001-7258-9596 [Term] id: CL:4023094 name: tufted pyramidal neuron def: "A pyramidal neuron which has a distinctive tuft formation, distal from the soma." [PMID:30715238] subset: BDS_subset subset: human_subset subset: mouse_subset is_a: CL:0000598 ! pyramidal neuron intersection_of: CL:0000540 ! neuron intersection_of: RO:0000053 PATO:0070018 ! has characteristic tufted pyramidal morphology relationship: RO:0000053 PATO:0070018 ! has characteristic tufted pyramidal morphology property_value: terms:contributor https://orcid.org/0000-0001-7258-9596 [Term] id: CL:4023095 name: untufted pyramidal neuron def: "A pyramidal neuron which lacks a clear tuft formation but extends to large radial distances." [PMID:30715238] subset: BDS_subset subset: human_subset subset: mouse_subset is_a: CL:0000598 ! pyramidal neuron intersection_of: CL:0000540 ! neuron intersection_of: RO:0000053 PATO:0070019 ! has characteristic untufted pyramidal morphology relationship: RO:0000053 PATO:0070019 ! has characteristic untufted pyramidal morphology property_value: terms:contributor https://orcid.org/0000-0001-7258-9596 [Term] id: CL:4023097 name: arachnoid barrier cell def: "A mesothelial fibroblast of the arachnoid barrier layer. Arachnoid barrier cells make up the tight-junctioned layer in the leptomeninx that functions as the physiologic barrier between the cerebrospinal fluid in the subarachnoid space and the fenestrated capillaries in the dura." [PMID:23298861] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "AB cell" RELATED OMO:0003000 [PMID:23298861] synonym: "ABC" RELATED OMO:0003000 [PMID:30096314] is_a: CL:4023058 ! mesothelial fibroblast of the leptomeninx relationship: BFO:0000050 UBERON:0000437 ! part of arachnoid barrier layer property_value: terms:contributor https://orcid.org/0000-0001-7258-9596 [Term] id: CL:4023098 name: obsolete L2/3 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (Homo sapiens) def: "OBSOLETE An intratelencephalic-projecting glutamatergic neuron with a soma found in layer 2/3 of the human primary motor cortex." [DOI:10.1101/2020.03.31.016972] comment: Made terms species agnostic, use CL:4023047 instead. synonym: "L2/3 IT MOp (human)" EXACT [] property_value: terms:contributor https://orcid.org/0000-0001-7258-9596 is_obsolete: true replaced_by: CL:4023047 [Term] id: CL:4023099 name: obsolete L5 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (Homo sapiens) def: "OBSOLETE. An intratelencephalic-projecting glutamatergic neuron with a soma found in layer 5 of the human primary motor cortex." [DOI:10.1101/2020.03.31.016972] comment: Made terms species agnostic, use CL:4023049 instead. synonym: "L5 IT MOp (human)" EXACT [] xref: ILX:0770157 property_value: terms:contributor https://orcid.org/0000-0001-7258-9596 is_obsolete: true replaced_by: CL:4023049 [Term] id: CL:4023100 name: obsolete L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (Homo sapiens) def: "OBSOLETE. An intratelencephalic-projecting glutamatergic neuron with a soma found in layer 6 of the human primary motor cortex." [DOI:10.1101/2020.03.31.016972] comment: Made terms species agnostic, use CL:4023050 instead. synonym: "L6 IT MOp (human)" EXACT [] xref: ILX:0770158 property_value: terms:contributor https://orcid.org/0000-0001-7258-9596 is_obsolete: true replaced_by: CL:4023050 [Term] id: CL:4023101 name: obsolete L5/6 near-projecting glutamatergic neuron of the primary motor cortex (Homo sapiens) def: "OBSOLETE. A near-projecting glutamatergic neuron with a soma found in layer 5/6 of the human primary motor cortex." [DOI:10.1101/2020.03.31.016972] comment: Made terms species agnostic, use CL:4023043 instead. synonym: "L5/6 NP MOp (human)" EXACT [] xref: ILX:0770161 property_value: terms:contributor https://orcid.org/0000-0001-7258-9596 is_obsolete: true replaced_by: CL:4023043 [Term] id: CL:4023102 name: obsolete L5/6 near-projecting glutamatergic neuron of the primary motor cortex (Callithrix jacchus) def: "OBSOLETE. A near-projecting glutamatergic neuron with a soma found in layer 5/6 of the marmoset primary motor cortex." [DOI:10.1101/2020.03.31.016972] comment: Made terms species agnostic, use CL:4023043 instead. synonym: "L5/6 NP MOp (marmoset)" EXACT [] xref: ILX:0770161 property_value: terms:contributor https://orcid.org/0000-0001-7258-9596 is_obsolete: true replaced_by: CL:4023043 [Term] id: CL:4023103 name: obsolete L2/3 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (Callithrix jacchus) def: "OBSOLETE. An intratelencephalic-projecting glutamatergic neuron with a soma found in layer 2/3 of the marmoset primary motor cortex." [DOI:10.1101/2020.03.31.016972] comment: Made terms species agnostic, use CL:4023047 instead. synonym: "L2/3 IT MOp (marmoset)" EXACT [] property_value: terms:contributor https://orcid.org/0000-0001-7258-9596 is_obsolete: true replaced_by: CL:4023047 [Term] id: CL:4023104 name: obsolete L5 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (Callithrix jacchus) def: "OBSOLETE An intratelencephalic-projecting glutamatergic neuron with a soma found in layer 5 of the marmoset primary motor cortex." [DOI:10.1101/2020.03.31.016972] comment: Made terms species agnostic, use CL:4023049 instead. synonym: "L5 IT MOp (marmoset)" EXACT [] xref: ILX:0770157 property_value: terms:contributor https://orcid.org/0000-0001-7258-9596 is_obsolete: true replaced_by: CL:4023049 [Term] id: CL:4023105 name: obsolete L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (Callithrix jacchus) def: "OBSOLETE. An intratelencephalic-projecting glutamatergic neuron with a soma found in layer 6 of the marmoset primary motor cortex." [DOI:10.1101/2020.03.31.016972] comment: Made terms species agnostic, use CL:4023050 instead. subset: BDS_subset synonym: "L6 IT MOp (marmoset)" EXACT [] xref: ILX:0770158 property_value: terms:contributor https://orcid.org/0000-0001-7258-9596 is_obsolete: true replaced_by: CL:4023050 [Term] id: CL:4023106 name: obsolete meis2 expressing cortical GABAergic cell (Callithrix jacchus) def: "OBSOLETE. A mouse GABAergic cell located in the marmoset cerebral cortex that expresses meis2." [DOI:10.1101/2020.03.31.016972] comment: false synonym: "Meis2 (Marmoset)" EXACT [] property_value: terms:contributor https://orcid.org/0000-0001-7258-9596 is_obsolete: true replaced_by: CL:4023065 [Term] id: CL:4023107 name: reticulospinal neuron def: "A neuron with soma location in the reticular formation with axons that extend into the spinal cord such. Reticulospinal neuron activity can lead to a variety of motor behaviors." [PMID:29720934] subset: human_subset subset: mouse_subset synonym: "RSN" EXACT [PMID:29720934] is_a: BFO:0000002 is_a: CL:2000029 ! central nervous system neuron intersection_of: CL:0000540 ! neuron intersection_of: RO:0002100 UBERON:0002275 ! has soma location reticular formation intersection_of: RO:0013001 UBERON:0002240 ! has synaptic IO in region spinal cord relationship: RO:0002100 UBERON:0002275 ! has soma location reticular formation relationship: RO:0013001 UBERON:0002240 ! has synaptic IO in region spinal cord property_value: terms:contributor https://orcid.org/0000-0001-7258-9596 [Term] id: CL:4023108 name: oxytocin-secreting magnocellular cell def: "A magnocellular neurosecretory cell that is capable of producing and secreting oxytocin." [WikipediaVersioned:Magnocellular_neurosecretory_cell&oldid=1021059931] subset: human_subset subset: mouse_subset is_a: CL:0011003 ! magnocellular neurosecretory cell intersection_of: CL:0011003 ! magnocellular neurosecretory cell intersection_of: RO:0002215 GO:0036162 ! capable of oxytocin production relationship: RO:0002215 GO:0036162 ! capable of oxytocin production property_value: terms:contributor https://orcid.org/0000-0001-7258-9596 [Term] id: CL:4023109 name: vasopressin-secreting magnocellular cell def: "A magnocellular neurosecretory cell that is capable of producing and secreting vasopressin." [WikipediaVersioned:Magnocellular_neurosecretory_cell&oldid=1021059931] subset: human_subset subset: mouse_subset is_a: CL:0000167 ! peptide hormone secreting cell is_a: CL:0011003 ! magnocellular neurosecretory cell intersection_of: CL:0011003 ! magnocellular neurosecretory cell intersection_of: RO:0002215 GO:0030103 ! capable of vasopressin secretion relationship: RO:0002215 GO:0030103 ! capable of vasopressin secretion property_value: terms:contributor https://orcid.org/0000-0001-7258-9596 [Term] id: CL:4023110 name: amygdala pyramidal neuron def: "A pyramidal neuron with soma located in the amygdala." [PMID:1375860] subset: human_subset subset: mouse_subset is_a: CL:0000598 ! pyramidal neuron is_a: CL:0012001 ! neuron of the forebrain intersection_of: CL:0000598 ! pyramidal neuron intersection_of: RO:0002100 UBERON:0001876 ! has soma location amygdala relationship: RO:0002100 UBERON:0001876 ! has soma location amygdala property_value: terms:contributor https://orcid.org/0000-0001-7258-9596 [Term] id: CL:4023111 name: cerebral cortex pyramidal neuron def: "A pyramidal neuron with soma located in the cerebral cortex." [PMID:30715238] subset: cellxgene_subset subset: human_subset subset: mouse_subset is_a: CL:0000598 ! pyramidal neuron is_a: CL:0010012 ! cerebral cortex neuron intersection_of: CL:0000598 ! pyramidal neuron intersection_of: RO:0002100 UBERON:0000956 ! has soma location cerebral cortex property_value: terms:contributor https://orcid.org/0000-0001-7258-9596 [Term] id: CL:4023112 name: vestibular afferent neuron def: "An afferent neuron of the vestibular system that innervate the base of the hair cell and increase or decrease their neural firing rate as the receptor cell is excited or inhibited." [PMID:2585041] subset: human_subset subset: mouse_subset is_a: CL:0000101 ! sensory neuron relationship: RO:0002120 CL:0000609 ! synapsed to vestibular hair cell property_value: terms:contributor https://orcid.org/0000-0001-7258-9596 [Term] id: CL:4023113 name: bouton vestibular afferent neuron def: "A vestibular afferent neuron that makes bouton synapses to type II hair cells." [PMID:10706428] subset: human_subset subset: mouse_subset is_a: CL:4023112 ! vestibular afferent neuron relationship: BFO:0000051 GO:0043195 ! has part terminal bouton relationship: RO:0002130 CL:0002069 ! has synaptic terminal in type II vestibular sensory cell property_value: terms:contributor https://orcid.org/0000-0001-7258-9596 [Term] id: CL:4023114 name: calyx vestibular afferent neuron def: "A vestibular afferent neuron which posseses a unique postsynaptic terminal, the calyx, which completely covers the basolateral walls of type I hair cells and receives input from multiple ribbon synapses." [PMID:25355208] subset: human_subset subset: mouse_subset is_a: CL:4023112 ! vestibular afferent neuron relationship: BFO:0000051 GO:0099096 ! has part vestibular calyx terminal relationship: RO:0002130 CL:0002070 ! has synaptic terminal in type I vestibular sensory cell property_value: terms:contributor https://orcid.org/0000-0001-7258-9596 [Term] id: CL:4023115 name: type 1 spiral ganglion neuron def: "A spiral ganglion neuron that innervates inner hair cells. Type 1 spiral ganglion neurons are myelinated and bipolar." [WikipediaVersioned:Spiral_ganglion&oldid=994446209] comment: Type 1 spiral ganglion neurons comprise the vast majority of spiral ganglion cells. {xref="WikipediaVersioned:Spiral_ganglion&oldid=994446209"} subset: human_subset subset: mouse_subset synonym: "type I spiral ganglion cell" EXACT [] is_a: CL:0011113 ! spiral ganglion neuron is_a: UBERON:0000122 ! neuron projection bundle intersection_of: CL:0011113 ! spiral ganglion neuron intersection_of: RO:0002134 CL:0000589 ! innervates cochlear inner hair cell relationship: RO:0000053 PATO:0070006 ! has characteristic cortical bipolar morphology relationship: RO:0002134 CL:0000589 ! innervates cochlear inner hair cell property_value: terms:contributor https://orcid.org/0000-0001-7258-9596 [Term] id: CL:4023116 name: type 2 spiral ganglion neuron def: "A spiral ganglion neuron that innervates outer hair cells. Type 1 spiral ganglion neurons are unmyelinated and unipolar." [WikipediaVersioned:Spiral_ganglion&oldid=994446209] comment: Outer hair cells form reciprocal synapses onto type 2 spiral ganglion cells, suggesting that the type 2 cells have both afferent and efferent roles. {xref="WikipediaVersioned:Spiral_ganglion&oldid=994446209"} subset: human_subset subset: mouse_subset synonym: "type II spiral ganglion cell" EXACT [] is_a: CL:0011113 ! spiral ganglion neuron is_a: UBERON:0000122 ! neuron projection bundle intersection_of: CL:0011113 ! spiral ganglion neuron intersection_of: RO:0002134 CL:0000601 ! innervates cochlear outer hair cell relationship: RO:0000053 PATO:0070025 ! has characteristic unipolar neuron morphology relationship: RO:0002134 CL:0000601 ! innervates cochlear outer hair cell property_value: terms:contributor https://orcid.org/0000-0001-7258-9596 [Term] id: CL:4023118 name: L5/6 non-Martinotti sst GABAergic interneuron (Mmus) def: "A sst GABAergic interneuron does not have Martinotti morphology with a soma found in L5/6 of the cerebral cortex." [PMID:27477017] comment: L5/6 non-Martinotti SST cells have strongly facilitating excitatory inputs and moderately depressing outputs. They have faster action potential than Martinotti morphology SST cells and slightly slower than PV basket cells. {xref="PMID:27477017"} subset: BDS_subset subset: mouse_subset synonym: "L5/6 non-Martinotti morphology sst expressing GABAergic cortical interneuron (Mus musculus)" EXACT [] synonym: "L5/6 non-Martinotti SST (Mus musculus)" EXACT [] is_a: BFO:0000002 is_a: CL:0010011 ! cerebral cortex GABAergic interneuron relationship: RO:0002100 UBERON:8440002 ! has soma location cortical layer V/VI relationship: RO:0002162 NCBITaxon:10090 ! in taxon Mus musculus relationship: RO:0002292 PR:P60041 ! expresses somatostatin (mouse) property_value: IAO:0000028 "L5/6 non-Martinotti sst interneuron (Mus)" xsd:string property_value: terms:contributor https://orcid.org/0000-0001-7258-9596 [Term] id: CL:4023119 name: displaced amacrine cell def: "A subpopulation of amacrine cell that migrate further than other amacrine cells, and come to lie basal to the inner plexiform layer (IPL) in the ganglion cell layer. Displaced amacrine cells still have their neurites extending apically into the IPL, and therefore exhibit an inverted polarity with respect to the other amacrine cells." [PMID:21557506, PMID:67960] comment: Displaced amacrine cells are a subset of Sox2 expressing amacrine cells. {xref="PMID:18719084"} subset: human_subset subset: mouse_subset synonym: "dACs" EXACT [] synonym: "inverted amacrine cell" EXACT [] is_a: CL:0000561 ! amacrine cell relationship: RO:0002292 PR:000015426 ! expresses transcription factor SOX-2 property_value: terms:contributor https://orcid.org/0000-0001-7258-9596 [Term] id: CL:4023120 name: cochlea auditory hair cell def: "An auditory hair cell found in the cochlea." [Wikipedia:Hair_cell] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "cochlear hair cell" EXACT [] xref: FMA:62364 is_a: BFO:0000002 is_a: CL:0000202 ! auditory hair cell is_a: CL:0002374 ! ear hair cell intersection_of: CL:0000202 ! auditory hair cell intersection_of: BFO:0000050 UBERON:0002227 ! part of spiral organ of cochlea relationship: BFO:0000050 UBERON:0002227 ! part of spiral organ of cochlea property_value: terms:contributor https://orcid.org/0000-0001-7258-9596 [Term] id: CL:4023121 name: sst chodl GABAergic interneuron def: "A transcriptomically distinct sst GABAergic interneuron that also expresses Chodl. These neurons are rare and correspond to the only known interneurons with long-range projection." [https://cellxgene.cziscience.com/e/9c63201d-bfd9-41a8-bbbc-18d947556f3d.cxg/, PMID:15845086, PMID:31209381, PMID:33372656, PMID:37824655] comment: The marker set NPY can identify the Human cell type sst chodl GABAergic interneuron in the neocortex with a confidence of 0.894026187 (NS-Forest FBeta value). {xref="https://doi.org/10.5281/zenodo.11165918"} subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "long-range GABAergic interneuron" BROAD [PMID:33372656] is_a: CL:4023017 ! sst GABAergic interneuron relationship: RO:0002292 PR:000005444 ! expresses chondrolectin relationship: RO:0015004 CLM:1000083 ! has characterizing marker set NS forest marker set of sst chodl GABAergic interneuron (Human neocortex). property_value: IAO:0000028 "sst chodl interneuron" xsd:string property_value: RO:0002175 NCBITaxon:9606 property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_4023121" xsd:string {name="sst chodl GABAergic interneuron on CELLxGENE CellGuide"} property_value: terms:contributor https://orcid.org/0000-0001-7258-9596 property_value: terms:description "The sst chodl GABAergic cortical interneuron is a specific rare type of inhibitory neuron found within the cortex of the brain. Specifically, sst refers to somatostatin, which is a peptide hormone produced by this cell. Chodl on the other hand, refers to chondrolectin, a protein highly expressed by this particular subtype of interneurons. GABAergic denotes the neurons' use of gamma-aminobutyric acid (GABA), a prominent inhibitory neurotransmitter, playing a crucial part in reducing neuronal excitability throughout the nervous system.\nGABAergic cortical interneurons expressing both sst and chodl markers play an instrumental role in balancing excitatory neural activities. Their inherent inhibitory polarity primarily functions to fine-tune the excitatory signals facilitated by the majority of cortical neurons, the pyramidal cells. Smooth dendrites and a propensity to innervate multiple targets allow these sst chodl GABAergic interneurons to control the output of many principal neurons simultaneously. This regulation results in a balanced state of neuronal activities, preventing any possibility of excess excitations that can potentially lead to brain disorders like epilepsy.\nIn a broader scope, sst expressing GABAergic cortical interneurons play a pivotal role in the higher cognitive processes. By controlling the timing and synchronization, they play an essential part in shaping the dynamic cortical network activities underlying complex brain functions, such as learning, memory, and attention. These interneurons are also likely involved in specific brain oscillatory patterns. Recent studies suggest that the dysfunction or misplacement of these interneurons can lead to neurological disorders such as schizophrenia or autism.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1016/j.neuron.2023.05.032", xref="DOI:10.1038/nn.4216", xref="DOI:10.1038/s41593-019-0417-0", xref="DOI:10.1093/schbul/sbaa184", xref="DOI:10.3389/fncir.2016.00076"} [Term] id: CL:4023122 name: oxytocin receptor sst GABAergic cortical interneuron def: "An interneuron located in the cerebral cortex that expresses the oxytocin receptor. These interneurons also express somatostatin." [PMID:25303526] comment: These cells were first identified in mouse. {xref="PMID:25303526"} subset: human_subset subset: mouse_subset synonym: "OxtrINs" RELATED OMO:0003000 [PMID:25303526] is_a: BFO:0000002 is_a: CL:0010011 ! cerebral cortex GABAergic interneuron relationship: RO:0002292 PR:000001635 ! expresses oxytocin receptor relationship: RO:0002292 PR:000015665 ! expresses somatostatin property_value: RO:0002175 NCBITaxon:10090 {xref="PMID:25303526"} property_value: terms:contributor https://orcid.org/0000-0001-7258-9596 [Term] id: CL:4023123 name: hypothalamus kisspeptin neuron def: "A kisspeptin neuron that is located in the hypothalamus. These neurons project to and activate gonadotrophin-releasing hormone neurons (acting via the kisspeptin receptor) in the hypothalamus and stimulate the secretion of gonadotrophin-releasing hormone." [PMID:30042117] subset: human_subset subset: mouse_subset is_a: CL:0012001 ! neuron of the forebrain is_a: CL:4023130 ! kisspeptin neuron intersection_of: CL:4023130 ! kisspeptin neuron intersection_of: RO:0002100 UBERON:0001898 ! has soma location hypothalamus relationship: RO:0002100 UBERON:0001898 ! has soma location hypothalamus property_value: terms:contributor https://orcid.org/0000-0001-7258-9596 property_value: terms:contributor https://orcid.org/0000-0002-0819-0473 [Term] id: CL:4023124 name: dentate gyrus kisspeptin neuron def: "A kisspeptin neuron that is located in the dentate gyrus of the hippocampus." [WikipediaVersioned:Kisspeptin&oldid=1042853037] subset: human_subset subset: mouse_subset is_a: CL:4023062 ! dentate gyrus neuron is_a: CL:4023130 ! kisspeptin neuron intersection_of: CL:4023130 ! kisspeptin neuron intersection_of: RO:0002100 UBERON:0001885 ! has soma location dentate gyrus of hippocampal formation property_value: terms:contributor https://orcid.org/0000-0001-7258-9596 property_value: terms:contributor https://orcid.org/0000-0002-0819-0473 [Term] id: CL:4023125 name: KNDy neuron def: "A hypothalamus kisspeptin neuron that coexpresses kisspeptin, neurokinin B and dynorphin." [WikipediaVersioned:KNDy_neuron&oldid=964682278] comment: KNDy neurons are involved in the negative feedback of gonadotropin-releasing hormone release in the hypothalamic–pituitary–gonadal axis. Sex steroids released from the gonads act on KNDy neurons as inhibitors of kisspeptin release. This inhibition provides negative feedback control on the hypothalamic–pituitary–gonadal axis. Other roles of KNDy neurons include influences on prolactin production; puberty; stress' effects on reproduction; and the control of thermoregulation. {xref="WikipediaVersioned:KNDy_neuron&oldid=964682278"} subset: human_subset subset: mouse_subset synonym: "kisspeptin, neurokinin B and dynorphin expressing neuron" EXACT [] is_a: CL:4023123 ! hypothalamus kisspeptin neuron intersection_of: CL:4023123 ! hypothalamus kisspeptin neuron intersection_of: RO:0002292 PR:000012526 ! expresses proenkephalin-B intersection_of: RO:0002292 PR:000016004 ! expresses tachykinin-3 relationship: RO:0002292 PR:000012526 ! expresses proenkephalin-B relationship: RO:0002292 PR:000016004 ! expresses tachykinin-3 property_value: terms:contributor https://orcid.org/0000-0001-7258-9596 property_value: terms:contributor https://orcid.org/0000-0002-0819-0473 [Term] id: CL:4023127 name: arcuate nucleus of hypothalamus KNDy neuron def: "a KNDy neuron that is located in the arcuate nucleus of the hypothalamus." [PMID:30042117] subset: human_subset subset: mouse_subset is_a: CL:4023125 ! KNDy neuron intersection_of: CL:4023125 ! KNDy neuron intersection_of: RO:0002100 UBERON:0001932 ! has soma location arcuate nucleus of hypothalamus relationship: RO:0002100 UBERON:0001932 ! has soma location arcuate nucleus of hypothalamus property_value: terms:contributor https://orcid.org/0000-0001-7258-9596 property_value: terms:contributor https://orcid.org/0000-0002-0819-0473 [Term] id: CL:4023128 name: rostral periventricular region of the third ventricle KNDy neuron def: "a KNDy neuron that is located in the rostral periventricular region of the third ventricle." [PMID:30042117, WikipediaVersioned:KNDy_neuron&oldid=964682278] subset: human_subset subset: mouse_subset synonym: "RP3V KNDy neuron" EXACT [] is_a: CL:4023125 ! KNDy neuron intersection_of: CL:4023125 ! KNDy neuron intersection_of: RO:0002100 UBERON:8440005 ! has soma location rostral periventricular region of the third ventricle relationship: RO:0002100 UBERON:8440005 ! has soma location rostral periventricular region of the third ventricle property_value: IAO:0000116 "In rats and mice, the anteroventral periventricular nucleus plus the periventricular nucleus make up the rostral periventricular region of the third ventricle (RP3V)." xsd:string {xref="WikipediaVersioned:Anteroventral_periventricular_nucleus&oldid=966137187"} property_value: terms:contributor https://orcid.org/0000-0001-7258-9596 property_value: terms:contributor https://orcid.org/0000-0002-0819-0473 [Term] id: CL:4023129 name: retinoblast def: "A retinal cell that is immature or undifferentiated." [PMID:17565741] subset: eye_upper_slim subset: human_subset subset: mouse_subset synonym: "retinal stem cell" EXACT [PMID:17565741] is_a: CL:0009004 ! retinal cell relationship: BFO:0000050 UBERON:0000966 ! part of retina property_value: terms:contributor https://orcid.org/0000-0001-7258-9596 property_value: terms:contributor https://orcid.org/0000-0002-0819-0473 [Term] id: CL:4023130 name: kisspeptin neuron def: "A neuron that expresses kisspeptin. These neurons are predominantly located in the hypothalamus, but also found in other parts of the brain including the hippocampal dentate gyrus." [PMID:30042117] comment: Gonadal sex steroids stimulate kisspeptin neurons in the RP3V, but inhibit kisspeptin neurons in the ARC. {xref="PMID:30042117"} subset: human_subset subset: mouse_subset is_a: BFO:0000002 is_a: CL:2000029 ! central nervous system neuron intersection_of: CL:0000540 ! neuron intersection_of: RO:0002292 PR:000009344 ! expresses metastasis-suppressor KiSS-1 relationship: RO:0002292 PR:000009344 ! expresses metastasis-suppressor KiSS-1 property_value: terms:contributor https://orcid.org/0000-0001-7258-9596 property_value: terms:contributor https://orcid.org/0000-0002-0819-0473 [Term] id: CL:4023154 name: myelinating glial cell alt_id: CL:0000328 def: "A glial cell that myelinates axonal processes." [DOI:10.1007/3-540-29623-9_3240] subset: human_subset subset: mouse_subset is_a: CL:0000125 ! glial cell intersection_of: CL:0000125 ! glial cell intersection_of: BFO:0000051 GO:0043209 ! has part myelin sheath relationship: BFO:0000051 GO:0043209 ! has part myelin sheath property_value: terms:contributor https://orcid.org/0000-0001-7258-9596 [Term] id: CL:4023158 name: octopus cell of the mammalian cochlear nucleus def: "A neuron in the posterior ventral cochlear nucleus that is distinguished by their long, thick and tentacle-shaped dendrites that typically emanate from one side of the cell body." [WikipediaVersioned:title=Cochlear_nucleus&oldid=1090176664] comment: Octopus cells respond only at the onset of a broad-band simple tonal stimulus and form a pathway to the superior paraolivary nucleus and to the ventral nucleus of the lateral lemniscus. {xref="WikipediaVersioned:title=Cochlear_nucleus&oldid=1090176664", xref="PMID:11976365"} subset: human_subset subset: mouse_subset is_a: BFO:0000002 is_a: CL:2000029 ! central nervous system neuron relationship: RO:0002100 UBERON:0002831 ! has soma location posteroventral cochlear nucleus relationship: RO:0013001 UBERON:8440043 ! has synaptic IO in region superior paraolivary nucleus property_value: IAO:0000116 "This term is restricted to the mammalian cochlear nucleus to disambiguate for cells of octopus." xsd:string property_value: terms:contributor http://orcid.org/0000-0001-7258-9596 [Term] id: CL:4023159 name: double bouquet cell def: "An interneuron that has double bouquet morphology." [PMID:15378039] subset: human_subset subset: mouse_subset is_a: CL:0000099 ! interneuron intersection_of: CL:0000099 ! interneuron intersection_of: RO:0000053 PATO:0070061 ! has characteristic double bouquet morphology relationship: RO:0000053 PATO:0070061 ! has characteristic double bouquet morphology property_value: terms:contributor http://orcid.org/0000-0001-7258-9596 [Term] id: CL:4023160 name: cartwheel cell def: "A neuron of the dorsal cochlear nucleus with spiny dendrites that receive input from the axons of granule cells and with axons that release GABA and glycine onto cartwheel, pyramidal and giant cell targets." [ILX:0102311, WikipediaVersioned:Cartwheel_cell&oldid=1040398094] comment: Cartwheel cells share many of the features, molecular and electrophysiological, of cerebellar Purkinje neurons. {xref="ILX:0102311"} subset: human_subset subset: mouse_subset xref: ILX:0102311 is_a: BFO:0000002 is_a: CL:0008059 ! GABA-Gly neuron is_a: CL:2000029 ! central nervous system neuron relationship: RO:0002100 UBERON:0002829 ! has soma location dorsal cochlear nucleus relationship: RO:0002103 CL:0000120 ! synapsed by granule cell property_value: terms:contributor http://orcid.org/0000-0001-7258-9596 [Term] id: CL:4023161 name: unipolar brush cell def: "An excitatory glutamatergic interneuron found in the granular layer of the cerebellar cortex and also in the granule cell domain of the cochlear nucleus. Unipolar brush cells have a round or oval cell body with usually a single short dendrite that ends in a brush-like tuft of short dendrites unique to them known as dendrioles." [PMID:9193142, WikipediaVersioned:Unipolar_brush_cell&oldid=1045937026] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "neuronal brush cell" EXACT [] is_a: BFO:0000002 is_a: CL:0000099 ! interneuron is_a: CL:0000679 ! glutamatergic neuron relationship: BFO:0000051 GO:0044293 ! has part dendriole relationship: RO:0000053 PATO:0070025 ! has characteristic unipolar neuron morphology relationship: RO:0002100 UBERON:0002028 ! has soma location hindbrain property_value: foaf:depiction Candelabrum:cell.jpg {dc:license="https://creativecommons.org/licenses/by-nc-nd/4.0/", xref="doi:10.3389/fnins.2020.00293"} property_value: foaf:depiction http://purl.obolibrary.org/obo/cl/images/CB_circuits_PMID3650468_f2.png {dc:license="https://creativecommons.org/licenses/by-nc-nd/4.0/", xref="doi:10.1016/j.cnp.2022.11.002"} property_value: skos:prefLabel "unipolar brush cell" xsd:string property_value: terms:contributor http://orcid.org/0000-0001-7258-9596 [Term] id: CL:4023162 name: bushy cell def: "A neuron found in the anterior part of the ventral cochlear nucleus that has the appearance of bushes, having short dendrites. Bushy cells give outputs to different parts of the superior olivary complex." [WikipediaVersioned:Bushy_cell&oldid=879061753] subset: human_subset subset: mouse_subset is_a: BFO:0000002 is_a: CL:2000029 ! central nervous system neuron relationship: RO:0002100 UBERON:0002830 ! has soma location anteroventral cochlear nucleus relationship: RO:0013001 UBERON:0002128 ! has synaptic IO in region superior olivary complex property_value: terms:contributor http://orcid.org/0000-0001-7258-9596 [Term] id: CL:4023163 name: spherical bushy cell def: "A bushy cell that receives only few large excitatory endbulb synapses from auditory nerves. Spherical bush cells give excitatory input to the lateral and medial parts of the superior olive." [PMID:31881018, WikipediaVersioned:Bushy_cell&oldid=879061753] subset: human_subset subset: mouse_subset synonym: "SBC" RELATED OMO:0003000 [PMID:31881018] is_a: CL:4023162 ! bushy cell property_value: terms:contributor http://orcid.org/0000-0001-7258-9596 [Term] id: CL:4023164 name: globular bushy cell def: "A bushy cell that receives a large number of medium-sized synapses, called modified endbulbs. Globular bushy cells extend to the superior olive on both sides of the brainstem where they give input to the bipolar neurons." [PMID:31881018, WikipediaVersioned:Bushy_cell&oldid=879061753] subset: human_subset subset: mouse_subset synonym: "GBC" EXACT OMO:0003000 [PMID:31881018] is_a: CL:4023162 ! bushy cell property_value: terms:contributor http://orcid.org/0000-0001-7258-9596 [Term] id: CL:4023168 name: somatosensory neuron def: "A neuron that is part of the somatic sensory system. Somatosensory neurons innervate the skin or integument to detect different types of thermal, chemical, and mechanical touch stimuli." [PMID:22865660] subset: human_subset subset: mouse_subset is_a: CL:2000032 ! peripheral nervous system neuron intersection_of: CL:0000540 ! neuron intersection_of: BFO:0000050 UBERON:0003942 ! part of somatosensory system intersection_of: RO:0002100 UBERON:0000010 ! has soma location peripheral nervous system relationship: BFO:0000050 UBERON:0003942 ! part of somatosensory system property_value: terms:contributor http://orcid.org/0000-0001-7258-9596 [Term] id: CL:4023169 name: trigeminal neuron def: "A neuron that is responsible for sensation in the face or motor functions such as biting and chewing. Trigeminal neurons extend a single axon shaft along the lateral white matter of the hindbrain and spinal cord. The highly branched axons innervate the integument of the head." [PMID:22190641, WikipediaVersioned:Trigeminal_nerve&oldid=1099897926] subset: cellxgene_subset subset: human_subset subset: mouse_subset is_a: CL:2000029 ! central nervous system neuron property_value: terms:contributor http://orcid.org/0000-0001-7258-9596 [Term] id: CL:4023170 name: trigeminal sensory neuron def: "A trigeminal neuron that is responsible for sensation in the face." [https://www.ncbi.nlm.nih.gov/books/NBK539823/] subset: human_subset subset: mouse_subset is_a: CL:0000006 ! neuronal receptor cell is_a: CL:4023169 ! trigeminal neuron intersection_of: CL:4023169 ! trigeminal neuron intersection_of: RO:0002215 GO:0050906 ! capable of detection of stimulus involved in sensory perception relationship: BFO:0000050 UBERON:0003942 ! part of somatosensory system property_value: terms:contributor http://orcid.org/0000-0001-7258-9596 [Term] id: CL:4023171 name: trigeminal motor neuron def: "A trigeminal neuron that is responsible for motor functions such as biting and chewing." [https://www.ncbi.nlm.nih.gov/books/NBK539823/] subset: human_subset subset: mouse_subset is_a: CL:0000100 ! motor neuron is_a: CL:4023169 ! trigeminal neuron intersection_of: CL:0000100 ! motor neuron intersection_of: CL:4023169 ! trigeminal neuron property_value: terms:contributor http://orcid.org/0000-0001-7258-9596 [Term] id: CL:4023181 name: hypendymal cell def: "A neurecto-epithelial cell that is part of the basal layer of the subcommissural organ and specializes in the secretion of proteins into the subarachnoid space. Hypendymal cells have similar characteristics to ependymal cells and express SCO-spondin." [https://orcid.org/0000-0001-7258-9596, PMID:26778959, PMID:9579598] subset: cellxgene_subset subset: human_subset subset: mouse_subset is_a: CL:0000710 ! neurecto-epithelial cell is_a: CL:0002319 ! neural cell relationship: BFO:0000050 UBERON:0002139 ! part of subcommissural organ relationship: RO:0002292 PR:000015658 ! expresses SCO-spondin property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_4023181" xsd:string {name="hypendymal cell on CELLxGENE CellGuide"} property_value: terms:contributor http://orcid.org/0000-0002-2105-0715 property_value: terms:description "Hypendymal cells are secretory cells located between the ependymal layer and the posterior commissure, forming the hypendmal layer of the subcommissural organ (SCO), a highly conserved gland that is part of the circumventricular system within the brain. \nHypendymal cells are bipolar cells with a thin apical pole and basal process. Most of the ultrastructural characteristics of these cells are similar to those described for the ependymal cells (which are arranged into another layer – the ependyma). However, ependymal cells release their secretion into the ventricular cerebrospinal fluid whereas hypendymal cells project processes to the local blood vessels and to the subarachnoidal space.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1002/(SICI)1097-0029(19980415)41:2<98::AID-JEMT2>3.0.CO;2-M", xref="DOI:10.1111/joa.13709", xref="DOI:10.3389/fncel.2015.00480"} [Term] id: CL:4023187 name: koniocellular cell def: "A neuron with a small cell body that is located in a koniocellular layer of the lateral geniculate nucleus (LGN)." [WikipediaVersioned:Lateral_geniculate_nucleus&oldid=1098375993] comment: In adult monkeys, koniocellular cells can be distinguished from parvocellular and magnocellular of the LGN by their expression of calbindin, the alpha subunit of type II calmodulin-dependent protein kinase, and the gamma subunit of protein kinase C. {xref="PMID:10845061"} subset: human_subset subset: mouse_subset synonym: "K cell" EXACT [PMID:10845061] xref: NIFEXT:44 is_a: CL:0012001 ! neuron of the forebrain intersection_of: CL:0000540 ! neuron intersection_of: RO:0002100 UBERON:0013615 ! has soma location koniocellular layer of dorsal nucleus of lateral geniculate body relationship: RO:0002100 UBERON:0013615 ! has soma location koniocellular layer of dorsal nucleus of lateral geniculate body property_value: terms:contributor http://orcid.org/0000-0001-7258-9596 [Term] id: CL:4023188 name: midget ganglion cell of retina def: "A retinal ganglion cell that originate in the ganglion cell layer of the retina, and project to the parvocellular layers of the lateral geniculate nucleus (LGN). These cells are known as midget retinal ganglion cells due to the small sizes of their dendritic trees and cell bodies." [PMID:32533915, WikipediaVersioned:Midget_cell&oldid=982299713] comment: There are midget bipolar cells of retina and midget ganglion cells of retina and they are not the same:\nMidget bipolar cells (imb, fmb) have larger axon terminals at greater distances from the fovea (retinal eccentricity of 4.5mm as compared to 12 mm). Midget ganglion cells (MGC) have larger dendritic fields (here seen at 8 mm) as they increase in eccentricity. subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset is_a: CL:0000740 ! retinal ganglion cell relationship: RO:0013001 UBERON:0013607 ! has synaptic IO in region parvocellular layer of dorsal nucleus of lateral geniculate body property_value: RO:0002175 NCBITaxon:9606 property_value: terms:contributor "https://orcid.org/0000-0001-7258-9596" xsd:string property_value: terms:contributor "https://orcid.org/0000-0001-7655-4833" xsd:string [Term] id: CL:4023189 name: parasol ganglion cell of retina def: "A retinal ganglion cell located in the ganglion cell layer of the retina. This cell projects to magnocellular cells in the lateral geniculate nucleus (LGN). They have large cell bodies and extensive, branching dendritic networks that contribute to their large receptive fields." [PMID:32533915, WikipediaVersioned:Parasol_cell&oldid=1032171532] comment: These cells should not be confused with M1-M14 retinal ganglion cells described in PMID:16626866 which refer to a different classification of retinal ganglion cells. subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "M cell" RELATED [] synonym: "M ganglion cell" RELATED [] is_a: CL:0000740 ! retinal ganglion cell relationship: RO:0013001 UBERON:0013606 ! has synaptic IO in region magnocellular layer of dorsal nucleus of lateral geniculate body property_value: RO:0002175 NCBITaxon:9606 property_value: terms:contributor "https://orcid.org/0000-0001-7258-9596" xsd:string property_value: terms:contributor "https://orcid.org/0000-0001-7655-4833" xsd:string [Term] id: CL:4028001 name: pulmonary capillary endothelial cell def: "Any capillary endothelial cell that is part of a lung." [] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "lung capillary endothelial cell" EXACT [] is_a: CL:0002144 ! capillary endothelial cell is_a: CL:2000016 ! lung microvascular endothelial cell intersection_of: CL:0002144 ! capillary endothelial cell intersection_of: BFO:0000050 UBERON:0002048 ! part of lung relationship: BFO:0000050 UBERON:0016405 ! part of pulmonary capillary property_value: terms:contributor https://orcid.org/0000-0002-3293-5463 creation_date: 2021-11-23T02:31:40Z [Term] id: CL:4028002 name: alveolar capillary type 1 endothelial cell def: "An alveolar capillary endothelial cell that is located distally to alveolar capillary type 2 endothelial cells." [PMID:31233341, PMID:32059772, PMID:32059779, PMID:32091393, PMID:33057196, PMID:33705684] subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "CAP1" RELATED OMO:0003000 [] synonym: "capillary 1 cell" BROAD [] synonym: "gCAP" RELATED OMO:0003000 [PMID:33057196] synonym: "general capillary cell" BROAD [PMID:33057196] is_a: CL:4028001 ! pulmonary capillary endothelial cell relationship: BFO:0000050 UBERON:0002299 ! part of alveolus of lung property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/2d-ftu/lung-pulmonary-alveolus/v1.3/assets/2d-ftu-lung-pulmonary-alveolus.png" xsd:string {terms:licence="http://creativecommons.org/licenses/by/4.0/", xref="doi:10.48539/HBM558.BZLS.992"} property_value: RO:0002175 NCBITaxon:9606 property_value: terms:contributor https://orcid.org/0000-0002-3293-5463 creation_date: 2021-11-23T03:23:53Z [Term] id: CL:4028003 name: alveolar capillary type 2 endothelial cell def: "An alveolar capillary endothelial cell that is located proximally to alveolar capillary type 1 endothelial cells and in close apposition to alveolar type 1 epithelial cells (also known as type I pneumocytes)." [PMID:31233341, PMID:32059772, PMID:32059779, PMID:32091393, PMID:33057196] subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "aCAP" RELATED OMO:0003000 [] synonym: "aerocyte" BROAD [PMID:33057196] synonym: "alveolar capillary cell" BROAD [] synonym: "capillary 2 cell" BROAD [] synonym: "Car4+ capillary endothelial cell" BROAD [] synonym: "CD34hi endothelial cells" BROAD [] is_a: CL:4028001 ! pulmonary capillary endothelial cell relationship: BFO:0000050 UBERON:0002299 ! part of alveolus of lung property_value: RO:0002175 NCBITaxon:9606 property_value: terms:contributor https://orcid.org/0000-0002-3293-5463 creation_date: 2021-11-23T03:23:53Z [Term] id: CL:4028004 name: alveolar type 1 fibroblast cell def: "A pulmonary interstitial fibroblast that is part of the alveolus and contains lipid droplets." [PMID:22268140, PMID:26706109, PMID:28886382, PMID:29489752, PMID:30675802, PMID:33624948, PMID:33707239, PMID:9074756] comment: The marker set AOC3, LUM can identify the Human cell type alveolar type 1 fibroblast cell in the lung with a confidence of 0.70 (NS-Forest FBeta value). {xref="https://doi.org/10.5281/zenodo.11165918"} subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "AF1" RELATED OMO:0003000 [] synonym: "alveolar fibroblast" BROAD [] synonym: "alveolar fibroblast 1" BROAD [] synonym: "lipid interstitial cell" BROAD [] synonym: "lipofibroblast" BROAD [] synonym: "matrix fibroblast 1" BROAD [] synonym: "pulmonary lipofibroblast" BROAD [] is_a: CL:0002241 ! pulmonary interstitial fibroblast is_a: CL:0002553 ! fibroblast of lung relationship: BFO:0000050 UBERON:0002299 ! part of alveolus of lung relationship: RO:0015004 CLM:1000002 ! has characterizing marker set NS forest marker set of alveolar type 1 fibroblast cell (Human lung). property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/2d-ftu/lung-pulmonary-alveolus/v1.3/assets/2d-ftu-lung-pulmonary-alveolus.png" xsd:string {terms:licence="http://creativecommons.org/licenses/by/4.0/", xref="doi:10.48539/HBM558.BZLS.992"} property_value: RO:0002175 NCBITaxon:9606 property_value: terms:contributor https://orcid.org/0000-0001-9610-7627 property_value: terms:contributor https://orcid.org/0000-0002-1425-877X property_value: terms:contributor https://orcid.org/0000-0002-3293-5463 property_value: terms:contributor https://orcid.org/0000-0002-8445-4565 creation_date: 2021-12-09T15:34:13Z [Term] id: CL:4028006 name: alveolar adventitial fibroblast def: "A pulmonary interstitial fibroblast that is part of the alveolus and localizes to vascular adventitia." [PMID:26706109, PMID:28886382, PMID:29752282, PMID:30675802, PMID:33208946, PMID:33624948] comment: The marker set SCARA5, CD248 can identify the Human cell type alveolar adventitial fibroblast in the lung with a confidence of 0.85 (NS-Forest FBeta value). {xref="https://doi.org/10.5281/zenodo.11165918"} subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "adventitial fibroblast" BROAD [] synonym: "AdvF" RELATED OMO:0003000 [PMID:33208946] synonym: "AF2" RELATED OMO:0003000 [] synonym: "alveolar fibroblast" BROAD [] synonym: "alveolar type 2 fibroblast cell" EXACT [] synonym: "MANC" RELATED OMO:0003000 [] synonym: "matrix fibroblast 2" BROAD [] synonym: "mesenchymal alveolar niche cell" BROAD [] synonym: "type-2 associated stromal cell" BROAD [] is_a: CL:0002241 ! pulmonary interstitial fibroblast is_a: CL:0002553 ! fibroblast of lung relationship: BFO:0000050 UBERON:0002299 ! part of alveolus of lung relationship: RO:0015004 CLM:1000001 ! has characterizing marker set NS forest marker set of alveolar adventitial fibroblast (Human lung). property_value: RO:0002175 NCBITaxon:9606 property_value: terms:contributor https://orcid.org/0000-0002-3293-5463 creation_date: 2021-12-09T15:53:21Z [Term] id: CL:4029001 name: gamete-nursing cell namespace: cell def: "A cell that supports the development of a gamete by providing it cytoplasmic material (including entire organelles) by direct cross-membrane channels (del Pino, 2021)." [doi:10.1016/bs.ctdb.2020.10.008] subset: human_subset subset: mouse_subset xref: BTO:0000953 is_a: CL:0000000 ! cell property_value: terms:contributor http://orcid.org/0000-0002-6095-8718 property_value: terms:date "2022-06-08T15:29:54Z" xsd:dateTime [Term] id: CL:4029002 name: germline-derived nurse cell namespace: cell def: "A gamete-nursing cell that derives from a germline cell (del Pino, 2021)." [doi:10.1016/bs.ctdb.2020.10.008] comment: Nurse cells were first described in insects, but recent works suggest they also exist in some mammals (Lei and Spradling, 2016). {xref="doi:10.1126/science.aad2156"} subset: human_subset subset: mouse_subset is_a: CL:0000039 ! germ line cell is_a: CL:4029001 ! gamete-nursing cell property_value: terms:contributor http://orcid.org/0000-0002-6095-8718 property_value: terms:date "2022-06-08T15:32:29Z" xsd:dateTime [Term] id: CL:4029003 name: somatic nurse-like cell namespace: cell def: "A gamete-nursing cell that derives from the somatic tissues of the gonad (del Pino, 2021)." [doi:10.1016/bs.ctdb.2020.10.008] comment: We follow what seems to be a common usage in the literature, which is to reserve the term “nurse cell” proper to cells from the germ line, hence the label “nurse-like”. This term encompasses pyriform cells described in reptiles, bird, and amphibians (del Pino, 2021); it does not encompass mammalian Sertoli cells, which do not appear to transfer cytoplasmic material to spermatogonia (França et al., 2016). {xref="doi:10.1111/andr.12165"} subset: human_subset subset: mouse_subset is_a: CL:4029001 ! gamete-nursing cell property_value: terms:contributor http://orcid.org/0000-0002-6095-8718 property_value: terms:date "2022-06-08T15:38:03Z" xsd:dateTime [Term] id: CL:4030000 name: choroidal melanocyte def: "A melanocyte located in the vascular uvea and involved in photoprotection, regulation of oxidative damage and immune responses." [http://orcid.org/0000-0002-0819-0473, PMID:31819095] comment: Cellular functions and extracellular interactions of choroidal melanocytes are distinct to skin melanocytes. They might have both neuroectodermal as well as mesectodermal origins. {xref="PMID:34082079", xref="PMID:31819095"} subset: human_subset subset: mouse_subset synonym: "uveal melanocyte" EXACT [] is_a: CL:0000148 ! melanocyte intersection_of: CL:0000148 ! melanocyte intersection_of: BFO:0000050 UBERON:0001768 ! part of uvea relationship: BFO:0000050 UBERON:0001768 ! part of uvea creation_date: 2022-01-20T12:59:06Z [Term] id: CL:4030001 name: stromal cell of thymus def: "A stromal cell that is part of the thymus." [doi:10.1038/s41467-020-20082-7] subset: human_subset subset: mouse_subset synonym: "thymic stromal cell" EXACT [] is_a: CL:0000499 ! stromal cell intersection_of: CL:0000499 ! stromal cell intersection_of: BFO:0000050 UBERON:0002370 ! part of thymus relationship: BFO:0000050 UBERON:0002370 ! part of thymus property_value: terms:date "2022-07-08T11:39:38Z" xsd:dateTime [Term] id: CL:4030002 name: effector memory CD45RA-positive, alpha-beta T cell, terminally differentiated def: "An alpha-beta memory T cell with the phenotype CD45RA-positive." [https://orcid.org/0000-0002-2825-0621] subset: human_subset subset: mouse_subset synonym: "effector memory RA T cell" BROAD [PMID:16237082] synonym: "TEMRA" BROAD [PMID:16237082] synonym: "TEMRA cell" EXACT [PMID:25104859] synonym: "terminally differentiated effector memory CD45RA+ T cells" EXACT [PMID:25104859] synonym: "terminally differentiated effector memory cells re-expressing CD45RA" EXACT [https://en.wikipedia.org/wiki/T_cell#Memory_T_cells] is_a: CL:0000791 ! mature alpha-beta T cell creation_date: 2022-02-01T13:04:46Z [Term] id: CL:4030003 name: interstitial cell of thymus def: "A cell that makes up the loose connective tissue of the thymus." [doi:10.1038/s41467-020-20082-7] subset: human_subset subset: mouse_subset synonym: "thymic interstitial cell" EXACT [] is_a: CL:4030001 ! stromal cell of thymus property_value: terms:date "2022-07-08T11:48:36Z" xsd:dateTime [Term] id: CL:4030004 name: thymic nurse cell def: "A large epithelial cell found in the thymus. This cell type may internalize thymocytes through extensions of plasma membrane. The cell surface and cytoplasmic vacuoles of a thymic nurse cell express MHC Class I and MHC Class II antigens. The interaction of these antigens with a developing thymocyte determines whether the thymocyte undergoes positive or negative selection." [https://en.wikipedia.org/wiki/Thymic_nurse_cell] subset: human_subset subset: mouse_subset is_a: CL:0002293 ! epithelial cell of thymus property_value: terms:contributor https://orcid.org/0000-0002-0819-0473 property_value: terms:date "2022-02-18T12:43:20Z" xsd:dateTime [Term] id: CL:4030005 name: kidney collecting duct beta-intercalated cell def: "A renal beta-intercalated cell that is part of the cortical collecting duct. The medullary collecting duct does not contain the renal beta-intercalated cell type." [PMID:24051376, PMID:31300091, PMID:32016094] subset: human_subset subset: mouse_subset synonym: "B-IC" EXACT [PMID:32016094] synonym: "kidney collecting duct intercalated cell type B" EXACT [PMID:31300091] is_a: CL:0002201 ! renal beta-intercalated cell is_a: CL:1000715 ! kidney cortex collecting duct intercalated cell intersection_of: CL:0002201 ! renal beta-intercalated cell intersection_of: BFO:0000050 UBERON:0004203 ! part of cortical collecting duct property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/2d-ftu/kidney-cortical-collecting-duct/v1.3/assets/2d-ftu-kidney-cortical-collecting-duct.png" xsd:string {terms:licence="http://creativecommons.org/licenses/by/4.0/", xref="doi:10.48539/HBM483.MXQP.399"} property_value: terms:date "2022-09-14T16:19:11Z" xsd:dateTime [Term] id: CL:4030006 name: fallopian tube secretory epithelial cell def: "An epithelial cell that is part of the fallopian tube that secretes mucus and oviduct-specific products in response to hormonal stimulation from estrogen and luteinizing hormone. This fallopian tube secretory cell is similar in height to the ciliated cell, but typically exhibits a more narrow, columnar shape. Its nucleus is ovoid and oriented perpendicular to the cell's long axis, with denser chromatin and a smaller nucleolus compared to the ciliated cell." [https://doi.org/10.1186/1477-7827-7-129, https://doi.org/10.3390/cells8080933, https://www.proteinatlas.org/learn/dictionary/normal/fallopian+tube] comment: The other cell types of the fallopian tube epithelium include the ciliated cell and the intercalary cell, or peg cell. The fallopian tube secretory epithelial cell type has been implicated as a source of high-grade serous ovarian carcinoma. {xref="https://doi.org/10.1016/j.ccr.2013.10.013", xref="https://www.proteinatlas.org/learn/dictionary/normal/fallopian+tube"} subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "oviduct secretory epithelial cell" BROAD [] synonym: "uterine tube secretory epithelial cell" EXACT [] is_a: CL:1001591 ! oviduct secretory cell is_a: CL:4052019 ! fallopian tube non-ciliated epithelial cell property_value: RO:0002175 NCBITaxon:9606 property_value: seeAlso "https://cellxgene.cziscience.com/cellguide/CL_4030006" xsd:string {name="fallopian tube secretory epithelial cell on CELLxGENE CellGuide"} property_value: terms:contributor https://orcid.org/0000-0002-0819-0473 property_value: terms:date "2022-03-03T10:39:31Z" xsd:dateTime property_value: terms:description "Fallopian tube secretory epithelial cells are non-ciliated cells that form an integral part of the epithelial lining of the fallopian tubes, the delicate conduits leading from the ovaries to the uterus in the female reproductive system. These cells are specialized to produce and secrete various biochemical substances necessary for gamete transportation, fertilization, and early embryonic development.\nA key function of the different subtypes of secretory epithelial cells is to release various substances, including proteins, glycoproteins, and ions that create an environment conducive to the journey of the ova from the ovaries to the uterus. The secretions aid in multiple ways, such as nourishing and protecting the oocytes, facilitating their transportation, and preparing them for potential fertilization. Some of these secretions, like tubal fluid, provide the essential medium for the oocyte's transit and the sperm's locomotion, thereby playing a critical role in successful fertilization.\nIn addition to their secretory function, fallopian tube secretory epithelial cells also contribute significantly to the formation of ciliated cells through differentiation, ensuring a functional fallopian epithelium and, subsequently, successful reproduction. They act as a frontline barrier against ascending infections by maintaining a robust immune environment. Recent studies also indicate their potential relevance in ovarian epithelial cancers, as the transformation of these cells might contribute to the development of this type of neoplasm.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1016/S0143-4004(99)80008-3", xref="DOI:10.1016/j.ccr.2013.10.013", xref="DOI:10.1016/j.devcel.2022.02.017", xref="DOI:10.1186/1471-2121-14-43", xref="DOI:10.1530/rep.0.1210339"} [Term] id: CL:4030007 name: fallopian tube multiciliated epithelial cell def: "A multi-ciliated epithelial cell that is part of the fallopian tube, mainly found on the apex of the mucosal folds. This cell exhibits a columnar shape with an oval nucleus and is characterized by the presence of cilia on its surface. The coordinated beating of these cilia, together with peristaltic contractions, contributes to the self-propulsion of spermatozoa, the transport of ovum during ovulation and the transport of the fertilized ovum to the intramural fallopian tube." [https://www.proteinatlas.org/humanproteome/tissue/fallopian+tube, PMID:16565155] subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "fallopian tube ciliated cell" EXACT [] synonym: "fallopian tube multiciliated cell" EXACT [] synonym: "oviduct ciliated cell" BROAD [] synonym: "uterine tube ciliated epithelial cell" EXACT [] is_a: CL:0005012 ! multiciliated epithelial cell is_a: CL:4052018 ! fallopian tube epithelial cell relationship: BFO:0000050 UBERON:0007589 ! part of ciliated columnar oviduct epithelium property_value: RO:0002175 NCBITaxon:9606 property_value: terms:contributor https://orcid.org/0000-0002-0819-0473 property_value: terms:date "2022-03-08T12:40:19Z" xsd:dateTime [Term] id: CL:4030008 name: pronephric podocyte def: "A specialized epithelial cell that contains \"feet\" that interdigitate with the \"feet\" of other glomerular epithelial cells in the pronephros." [PMID:10322630] subset: human_subset subset: mouse_subset synonym: "pronephric glomerular visceral epithelial cell" EXACT [ZFA:0001673] is_a: CL:0000653 ! podocyte intersection_of: CL:0000653 ! podocyte intersection_of: BFO:0000050 UBERON:0002120 ! part of pronephros relationship: BFO:0000050 UBERON:0002120 ! part of pronephros property_value: terms:contributor https://orcid.org/0000-0002-2244-7917 property_value: terms:date "2022-03-11T14:38:32Z" xsd:dateTime [Term] id: CL:4030009 name: epithelial cell of proximal tubule segment 1 def: "A brush border cell that is part of segment 1 (S1) of the proximal tubule epithelium, located in the renal cortex." [PMID:23799132, PMID:23897681, PMID:31249312] subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "epithelial cell of segment 1 of proximal tubule" EXACT [] is_a: CL:1000838 ! kidney proximal convoluted tubule epithelial cell intersection_of: CL:0000066 ! epithelial cell intersection_of: BFO:0000050 UBERON:0004196 ! part of proximal convoluted tubule segment 1 intersection_of: BFO:0000051 GO:0005903 ! has part brush border relationship: BFO:0000050 UBERON:0004196 ! part of proximal convoluted tubule segment 1 property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/2d-ftu/kidney-nephron/v1.2/assets/2d-ftu-kidney-nephron.png" xsd:string {terms:licence="http://creativecommons.org/licenses/by/4.0/", xref="doi:10.48539/HBM927.DQNW.448"} property_value: RO:0002175 NCBITaxon:9606 property_value: terms:date "2022-05-10T13:14:00Z" xsd:dateTime [Term] id: CL:4030010 name: epithelial cell of proximal tubule segment 2 def: "A brush border cell that is part of segment 2 (S2) of the proximal tubule epithelium, located in the renal cortex. In addition to its reabsorptive functions, it is also specialized in the secretion of organic anions and cations, including para-aminohippurate." [PMID:23799132, PMID:23897681, PMID:31249312, PMID:31253652] subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "epithelial cell of segment 2 of proximal tubule" EXACT [] is_a: CL:1000838 ! kidney proximal convoluted tubule epithelial cell intersection_of: CL:0000066 ! epithelial cell intersection_of: BFO:0000050 UBERON:0004197 ! part of proximal convoluted tubule segment 2 intersection_of: BFO:0000051 GO:0005903 ! has part brush border relationship: BFO:0000050 UBERON:0004197 ! part of proximal convoluted tubule segment 2 property_value: RO:0002175 NCBITaxon:9606 property_value: terms:date "2022-05-10T13:26:13Z" xsd:dateTime [Term] id: CL:4030011 name: epithelial cell of proximal tubule segment 3 def: "A brush border cell that is part of segment 3 (S3) of the proximal tubule epithelium, which extends from the medullary rays of the renal cortex into the outer medulla." [PMID:23799132, PMID:31249312] comment: The epithelial cell of proximal tubule segment 3 operates under relatively hypoxic conditions and is particularly susceptible to ischemic injury. {xref="PMID:31249312"} subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "epithelial cell of segment 3 of proximal tubule" EXACT [] is_a: CL:0002307 ! brush border cell of the proximal tubule is_a: CL:1000839 ! kidney proximal straight tubule epithelial cell intersection_of: CL:0000066 ! epithelial cell intersection_of: BFO:0000050 UBERON:0001290 ! part of proximal straight tubule intersection_of: BFO:0000051 GO:0005903 ! has part brush border property_value: RO:0002175 NCBITaxon:9606 property_value: terms:date "2022-05-10T13:31:06Z" xsd:dateTime [Term] id: CL:4030012 name: kidney loop of Henle short descending thin limb epithelial cell def: "Epithelial cell of the descending thin limb of the short loop (cortical) nephron limited to the outer medulla (mainly inner strip). It is known in some mammalian species that the short descending limb of the loop of Henle selectively expresses the serine protease Corin, the homeobox TF Uncx, and the urea channel Slc14a2." [PMID:33769951] subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "epithelial cell of the descending thin limb of the short loop of Henle" EXACT [] is_a: CL:0000076 ! squamous epithelial cell is_a: CL:1001111 ! kidney loop of Henle thin descending limb epithelial cell intersection_of: CL:0000066 ! epithelial cell intersection_of: BFO:0000050 UBERON:0005099 ! part of short descending thin limb relationship: BFO:0000050 UBERON:0005099 ! part of short descending thin limb property_value: RO:0002175 NCBITaxon:9606 property_value: terms:contributor https://orcid.org/0000-0003-2804-127X property_value: terms:date "2022-05-13T11:00:29Z" xsd:dateTime [Term] id: CL:4030013 name: kidney loop of Henle long descending thin limb outer medulla epithelial cell def: "Epithelial cell of the descending thin limb of the long loop (juxtamedullary) nephron that spans the outer medulla (inner stripe). It is known in some mammalian species that the long descending limb of the loop of Henle in the outer medulla selectively expresses the secreted activin-antagonist protein follistatin (Fst), the GPI-linked adhesion protein Cdh13, and the protein kinase Stk32a." [http://orcid.org/0000-0003-2804-127X, PMID:33769951] subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "epithelial cell of the outer medulla of the long descending limb of the loop of Henle" EXACT [] is_a: CL:1001111 ! kidney loop of Henle thin descending limb epithelial cell relationship: BFO:0000050 UBERON:0005100 ! part of long descending thin limb property_value: RO:0002175 NCBITaxon:9606 property_value: terms:date "2022-05-13T11:11:07Z" xsd:dateTime [Term] id: CL:4030014 name: kidney loop of Henle long descending thin limb inner medulla epithelial cell def: "Epithelial cell of the descending thin limb of the long loop (juxtamedullary) nephron that spans the inner medulla. It is known in some mammalian species that the long descending limb of the loop of Henle in the inner medulla selectively expresses the nuclear receptor Nr2e3, the Ig kappa chain Igkc, and the secreted protein dermokine (Dmkn). SLC14A2, which expresses a urea transporter, is also expressed in the inner medulla." [http://orcid.org/0000-0003-2804-127X, https://www.ncbi.nlm.nih.gov/gene/8170, PMID:33769951] subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "epithelial cell of the inner medulla of the long descending limb of the loop of Henle" EXACT [] is_a: CL:1001111 ! kidney loop of Henle thin descending limb epithelial cell relationship: BFO:0000050 UBERON:0005100 ! part of long descending thin limb property_value: RO:0002175 NCBITaxon:9606 property_value: terms:date "2022-05-13T11:16:54Z" xsd:dateTime [Term] id: CL:4030015 name: kidney collecting duct alpha-intercalated cell def: "A renal alpha-intercalated cell that is part of the collecting duct of the renal tubule." [PMID:31249312, PMID:9890303] subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "kidney collecting duct intercalated cell type A" EXACT [PMID:9890303] is_a: CL:0005011 ! renal alpha-intercalated cell is_a: CL:1001432 ! kidney collecting duct intercalated cell intersection_of: CL:0005011 ! renal alpha-intercalated cell intersection_of: BFO:0000050 UBERON:0001232 ! part of collecting duct of renal tubule property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/2d-ftu/kidney-cortical-collecting-duct/v1.3/assets/2d-ftu-kidney-cortical-collecting-duct.png" xsd:string {terms:licence="http://creativecommons.org/licenses/by/4.0/", xref="doi:10.48539/HBM483.MXQP.399"} property_value: RO:0002175 NCBITaxon:9606 property_value: terms:contributor https://orcid.org/0000-0003-2804-127X property_value: terms:date "2022-05-31T11:15:10Z" xsd:dateTime [Term] id: CL:4030016 name: epithelial cell of early distal convoluted tubule def: "An epithelial cell located in the early distal convoluted tubule." [http://orcid.org/0000-0003-2804-127X, PMID:24855283] subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "DCT1 cell" BROAD [PMID:24855283] is_a: CL:1000849 ! kidney distal convoluted tubule epithelial cell intersection_of: CL:0000066 ! epithelial cell intersection_of: BFO:0000050 UBERON:0005101 ! part of early distal convoluted tubule relationship: BFO:0000050 UBERON:0005101 ! part of early distal convoluted tubule property_value: RO:0002175 NCBITaxon:9606 property_value: terms:date "2022-06-21T12:47:48Z" xsd:dateTime [Term] id: CL:4030017 name: epithelial cell of late distal convoluted tubule def: "An epithelial cell located in the late distal convoluted tubule." [http://orcid.org/0000-0003-2804-127X, PMID:24855283] comment: Although mineralocorticoid receptors are expressed throughout the entire [distal convoluted tubule], the DCT2 is sensitive to the actions of aldosterone, because it expresses an enzyme called 11-β hydroxysteroid dehydrogenase 2 (11-βHSD2) {xref="PMID:24855283"} subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "DCT2 cell" BROAD [PMID:24855283] is_a: CL:1000849 ! kidney distal convoluted tubule epithelial cell intersection_of: CL:0000066 ! epithelial cell intersection_of: BFO:0000050 UBERON:0005102 ! part of late distal convoluted tubule relationship: BFO:0000050 UBERON:0005102 ! part of late distal convoluted tubule property_value: RO:0002175 NCBITaxon:9606 property_value: terms:date "2022-06-21T13:51:46Z" xsd:dateTime [Term] id: CL:4030018 name: kidney connecting tubule principal cell def: "A renal principal cell located in the connecting tubule." [http://orcid.org/0000-0003-2804-127X, PMID:27582101, PMID:31249312] subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset is_a: CL:0005009 ! renal principal cell is_a: CL:1000768 ! kidney connecting tubule epithelial cell intersection_of: CL:0005009 ! renal principal cell intersection_of: BFO:0000050 UBERON:0005097 ! part of renal connecting tubule property_value: RO:0002175 NCBITaxon:9606 property_value: terms:date "2022-06-27T15:25:10Z" xsd:dateTime [Term] id: CL:4030019 name: kidney connecting tubule intercalated cell def: "A renal intercalated cell that is part of the renal connecting tubule." [PMID:9890303] subset: human_reference_atlas subset: human_subset subset: mouse_subset is_a: CL:0005010 ! renal intercalated cell is_a: CL:1000768 ! kidney connecting tubule epithelial cell intersection_of: CL:0005010 ! renal intercalated cell intersection_of: BFO:0000050 UBERON:0005097 ! part of renal connecting tubule property_value: RO:0002175 NCBITaxon:9606 property_value: terms:date "2022-06-29T11:25:22Z" xsd:dateTime [Term] id: CL:4030020 name: kidney connecting tubule alpha-intercalated cell def: "A renal alpha-intercalated cell that is part of the renal connecting tubule." [PMID:2254448, PMID:24937428, PMID:9890303] subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "connecting tubule A-IC" EXACT [PMID:24937428] synonym: "kidney connecting tubule intercalated cell type A" EXACT [PMID:9890303] is_a: CL:0005011 ! renal alpha-intercalated cell is_a: CL:4030019 ! kidney connecting tubule intercalated cell intersection_of: CL:0005011 ! renal alpha-intercalated cell intersection_of: BFO:0000050 UBERON:0005097 ! part of renal connecting tubule property_value: RO:0002175 NCBITaxon:9606 property_value: terms:date "2022-06-29T12:48:43Z" xsd:dateTime [Term] id: CL:4030021 name: kidney connecting tubule beta-intercalated cell def: "A renal beta-intercalated cell that is part of the renal connecting tubule." [PMID:2254448, PMID:9890303] subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "connecting tubule B-IC" EXACT [PMID:32065116] synonym: "kidney connecting tubule intercalated cell type B" EXACT [PMID:9890303] is_a: CL:0002201 ! renal beta-intercalated cell is_a: CL:4030019 ! kidney connecting tubule intercalated cell intersection_of: CL:0002201 ! renal beta-intercalated cell intersection_of: BFO:0000050 UBERON:0005097 ! part of renal connecting tubule property_value: RO:0002175 NCBITaxon:9606 property_value: terms:date "2022-06-29T14:31:18Z" xsd:dateTime [Term] id: CL:4030022 name: renal medullary fibroblast def: "A fibroblast that is located in the renal medulla interstitium." [https://doi.org/10.1101/2021.07.28.454201, PMID:10559635] comment: It has been noted that inner medullary fibroblasts are involved in the regulation of water and electrolyte homeostasis. {xref="PMID:10559635"} subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "kidney medullary fibroblast" EXACT [] is_a: CL:1000682 ! kidney medulla interstitial cell is_a: CL:1000692 ! kidney interstitial fibroblast intersection_of: CL:0000057 ! fibroblast intersection_of: BFO:0000050 UBERON:0005211 ! part of renal medulla interstitium property_value: RO:0002175 NCBITaxon:9606 property_value: terms:date "2022-07-05T12:13:40Z" xsd:dateTime [Term] id: CL:4030023 name: respiratory tract hillock cell def: "A hillock cell that is located in respiratory epithelium. In some mammalian species, this cell type has been noted to express KRT13 and KRT4 and is postulated to play a role in squamous barrier function and immunomodulation." [https://orcid.org/0000-0001-7772-9578, PMID:30069044, PMID:32726565, PMID:33442032] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "hillock cell of respiratory tract" EXACT [] synonym: "respiratory hillock cell" EXACT [] is_a: CL:0002368 ! respiratory tract epithelial cell is_a: CL:4030024 ! hillock cell intersection_of: CL:4030024 ! hillock cell intersection_of: BFO:0000050 UBERON:0004802 ! part of respiratory tract epithelium property_value: terms:date "2022-06-06T08:31:09Z" xsd:dateTime [Term] id: CL:4030024 name: hillock cell def: "An epithelial, transitional cell type between basal and secretory; located in stratified, non-ciliated structures (called hillocks) with high cell turnover in epithelium. In some mammalian species, this cell type has been noted to express KRT13 and is postulated to play a role in squamous barrier function and immunomodulation." [PMID:30069044] subset: human_subset subset: mouse_subset is_a: CL:0000066 ! epithelial cell property_value: terms:date "2022-06-24T14:52:24Z" xsd:dateTime [Term] id: CL:4030025 name: renal cortical fibroblast def: "A fibroblast that is located in the renal cortical interstitium." [PMID:10559635] comment: Renal cortical fibroblasts have key roles in mediating intercellular communication with neighboring/infiltrating cells and extracellular matrix and maintenance of renal tissue architecture. They additionally have an endocrine function in the production of epoetin. {xref="PMID:16230044"} subset: human_subset subset: mouse_subset synonym: "kidney cortical fibroblast" EXACT [] is_a: CL:1000681 ! kidney cortex interstitial cell is_a: CL:1000692 ! kidney interstitial fibroblast intersection_of: CL:0000057 ! fibroblast intersection_of: BFO:0000050 UBERON:0005270 ! part of renal cortex interstitium property_value: terms:date "2022-07-05T15:50:17Z" xsd:dateTime [Term] id: CL:4030026 name: BEST4+ enterocyte def: "An enterocyte of the human intestine expressing bestrophin-4 (BEST4) calcium-activated ion channels." [https://orcid.org/0000-0002-7431-4139, PMID:24223998, PMID:35176508] subset: cellxgene_subset subset: human_subset is_a: CL:0000584 ! enterocyte intersection_of: CL:0000584 ! enterocyte intersection_of: RO:0002292 PR:Q8NFU0 ! expresses bestrophin-4 (human) relationship: RO:0002162 NCBITaxon:9606 ! in taxon Homo sapiens relationship: RO:0002292 PR:Q8NFU0 ! expresses bestrophin-4 (human) property_value: terms:date "2022-09-07T12:34:20Z" xsd:dateTime [Term] id: CL:4030027 name: GABAergic amacrine cell def: "An amacrine cell that uses GABA as a neurotransmitter." [https://doi.org/10.1016/j.cell.2020.08.013] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "amacrine cell, GABAergic" EXACT [] is_a: CL:0000561 ! amacrine cell is_a: CL:0011005 ! GABAergic interneuron intersection_of: CL:0000561 ! amacrine cell intersection_of: RO:0002215 GO:0061534 ! capable of gamma-aminobutyric acid secretion, neurotransmission property_value: terms:date "2022-10-17T12:35:11Z" xsd:dateTime [Term] id: CL:4030028 name: glycinergic amacrine cell def: "An amacrine cell that uses glycine as a neurotransmitter." [https://doi.org/10.1016/j.cell.2020.08.013] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "amacrine cell, glycinergic" EXACT [] is_a: CL:0000561 ! amacrine cell is_a: CL:1001509 ! glycinergic neuron intersection_of: CL:0000561 ! amacrine cell intersection_of: RO:0002215 GO:0061537 ! capable of glycine secretion, neurotransmission property_value: terms:date "2022-10-17T12:40:06Z" xsd:dateTime [Term] id: CL:4030029 name: blood lymphocyte def: "A lymphocyte located in blood." [https://orcid.org/0000-0001-9990-8331] subset: blood_and_immune_upper_slim subset: human_subset subset: mouse_subset is_a: CL:0000542 ! lymphocyte is_a: CL:2000001 ! peripheral blood mononuclear cell intersection_of: CL:0000542 ! lymphocyte intersection_of: BFO:0000050 UBERON:0000178 ! part of blood property_value: terms:date "2022-11-04T14:40:00Z" xsd:dateTime [Term] id: CL:4030030 name: peripheral blood lymphocyte def: "A blood lymphocyte located in the flowing, circulating blood of the body." [https://orcid.org/0000-0001-9990-8331, https://orcid.org/0000-0003-2534-198X, https://sciencing.com/what-peripheral-blood-4672930.html, PMID:31092833] subset: human_subset subset: mouse_subset is_a: CL:4030029 ! blood lymphocyte relationship: RO:0001025 UBERON:0013755 ! located in arterial blood relationship: RO:0001025 UBERON:0013756 ! located in venous blood property_value: seeAlso "https://github.com/obophenotype/cell-ontology/pull/1725" xsd:string property_value: terms:date "2022-11-14T10:08:14Z" xsd:dateTime [Term] id: CL:4030031 name: interstitial cell def: "Any cell that is located within the interstitium between the cells most prominent in defining a given tissue. \"Interstitial cell\" is a morphological term and refers to a variety of cells with differing origins and phenotypes." [PMID:24987007] subset: cellxgene_subset subset: human_subset subset: mouse_subset is_a: CL:0000255 ! eukaryotic cell intersection_of: CL:0000000 ! cell intersection_of: BFO:0000050 UBERON:0005169 ! part of interstitial tissue relationship: BFO:0000050 UBERON:0005169 ! part of interstitial tissue property_value: terms:date "2022-11-30T14:35:08Z" xsd:dateTime [Term] id: CL:4030032 name: valve interstitial cell def: "An interstitial cell that is part of a cardiac valve leaflet. Along with valve endothelial cells, a valve interstitial cell maintains tissue homeostasis for the function of cardiac valves through secreting biochemical signals, matrix proteins and matrix remodeling enzymes." [https://doi.org/10.1098/rsif.2017.0580, https://doi.org/10.1161/ATVBAHA.120.314789, https://doi.org/10.1161/JAHA.117.006339, https://doi.org/10.2353/ajpath.2007.070251, https://orcid.org/0000-0001-7655-4833, PMID:25311230] comment: Activated valve interstitial cells undergo continual turn over into deactivated fibroblasts and other cell fates (such as apoptosis). {xref="PMID:25311230"} subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "cardiac valve interstitial cell" EXACT [] synonym: "valvular interstitial cell" EXACT [PMID:25311230] synonym: "VIC" EXACT OMO:0003000 [PMID:25311230, PMID:30796046] is_a: CL:0000151 ! secretory cell is_a: CL:1000147 ! cardiac valve cell is_a: CL:4030031 ! interstitial cell intersection_of: CL:4030031 ! interstitial cell intersection_of: BFO:0000050 UBERON:0000946 ! part of cardiac valve relationship: RO:0002215 GO:0070278 ! capable of extracellular matrix constituent secretion property_value: RO:0002175 NCBITaxon:9606 property_value: terms:date "2022-12-06T14:18:45Z" xsd:dateTime [Term] id: CL:4030033 name: valve endothelial cell def: "An endothelial cell that lines a surface of a cardiac valve leaflet. Along with valve interstitial cells, a valve endothelial cell maintains tissue homeostasis for the function of cardiac valves through secreting biochemical signals, matrix proteins and matrix remodeling enzymes." [PMID:25311230] comment: At least in some mammalian species, a valve endothelial cell expresses CD31. Valve endothelial cells can undergo an endothelial to mesenchymal transition to acquire a fibroblast or myofibroblast phenotype that leads to changes in the microenvironmental signals and facilitates tissue regeneration. {xref="PMID:25311230"} subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "valvular endothelial cell" EXACT [PMID:25311230] synonym: "VEC" EXACT OMO:0003000 [PMID:25311230, PMID:30796046] is_a: CL:0010008 ! cardiac endothelial cell is_a: CL:1000147 ! cardiac valve cell intersection_of: CL:0000115 ! endothelial cell intersection_of: BFO:0000050 UBERON:0000946 ! part of cardiac valve property_value: terms:date "2022-12-09T11:58:49Z" xsd:dateTime [Term] id: CL:4030034 name: respiratory tract multiciliated cell def: "A multiciliated epithelial cell located in the respiratory tract epithelium, characterized by a columnar shape and motile cilia on its apical surface. This cell develops through a highly orchestrated process, transitioning from a basal progenitor via an intermediate deuterosomal cell stage that generates centrioles essential for ciliogenesis." [PMID:18757316, PMID:21364219, PMID:34044844, PMID:37834236] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "ciliated cell of the respiratory tract" EXACT [] synonym: "respiratory ciliated cell" EXACT [] synonym: "respiratory multiciliated cell" EXACT [] is_a: CL:0002368 ! respiratory tract epithelial cell is_a: CL:0005012 ! multiciliated epithelial cell intersection_of: CL:0000075 ! columnar/cuboidal epithelial cell intersection_of: BFO:0000050 UBERON:0004802 ! part of respiratory tract epithelium intersection_of: BFO:0000051 GO:0031514 ! has part motile cilium intersection_of: RO:0000053 PATO:0010007 ! has characteristic multiciliated relationship: RO:0002207 CL:4033044 ! directly develops from deuterosomal cell property_value: terms:date "2023-01-25T11:06:01Z" xsd:dateTime [Term] id: CL:4030035 name: dental pulp stem cell def: "A dental pulp cell that possesses stem-cell-like qualities, including self-renewal capability and multi-lineage differentiation." [DOI:10.1177/154405910208100806, https://orcid.org/0000-0002-2825-0621] subset: human_subset subset: mouse_subset synonym: "DPSC" EXACT OMO:0003000 [] is_a: CL:0000034 ! stem cell is_a: CL:0002148 ! dental pulp cell intersection_of: CL:0000034 ! stem cell intersection_of: BFO:0000050 UBERON:0001754 ! part of dental pulp property_value: terms:date "2023-01-10T14:02:02Z" xsd:dateTime [Term] id: CL:4030036 name: early spermatid def: "A spermatid in an early stage of maturation that has a round morphology and is transcriptionally active." [https://www.proteinatlas.org/humanproteome/single+cell+type/Germ+cells#earlyspermatids] subset: human_subset subset: mouse_subset synonym: "round spermatid" EXACT [https://doi.org/10.1016/B978-0-323-01970-5.50014-2] is_a: CL:0000018 ! spermatid relationship: BFO:0000050 UBERON:0000079 ! part of male reproductive system relationship: RO:0002215 GO:0007286 ! capable of spermatid development property_value: terms:date "2023-02-01T13:56:00Z" xsd:dateTime [Term] id: CL:4030037 name: late spermatid def: "A spermatid in a late stage of maturation that has an elongated morphology and is transcriptionally inert when the acrosome is fully developed." [https://www.proteinatlas.org/humanproteome/single+cell+type/Germ+cells#latespermatids] subset: human_subset subset: mouse_subset synonym: "elongated spermatid" EXACT [https://doi.org/10.1016/B978-0-323-01970-5.50014-2] is_a: CL:0000018 ! spermatid relationship: BFO:0000050 UBERON:0000079 ! part of male reproductive system relationship: RO:0002202 CL:4030036 ! develops from early spermatid relationship: RO:0002215 GO:0007286 ! capable of spermatid development property_value: terms:date "2023-02-01T14:02:15Z" xsd:dateTime [Term] id: CL:4030038 name: CD24-positive, CD-133-positive, vimentin-positive proximal tubular cell def: "A CD24-positive, CD-133-positive, vimentin-positive cell found scattered throughout a renal proximal tubule and that may participate in tubular regeneration. Compared to other proximal tubular cell types, this cell contains less cytoplasm, fewer mitochondria and no brush border." [PMID:21281815, PMID:23124355] comment: After acute tubular injury, this cell type becomes more numerous. In healthy rat kidneys, this cell is not detectable, whereas after unilateral ureteral obstruction (renal injury), it may appear de novo, arguing against the notion that this cell type represents a pre-existing progenitor cell population. In at least one study, data indicate that this cell type represents transiently dedifferentiated tubular cells involved in regeneration. {xref="PMID:23124355"} subset: human_subset subset: mouse_subset synonym: "CD133+CD24+CD106- tubular cell" BROAD [https://doi.org/10.1002/stem.1130] synonym: "CD24+CD133+ tubular cell" BROAD [PMID:23124355] synonym: "CD24-positive tubular cell" BROAD [PMID:23124355] is_a: CL:0002306 ! epithelial cell of proximal tubule relationship: BFO:0000050 UBERON:0008404 ! part of proximal tubular epithelium relationship: RO:0002292 PR:000001786 ! expresses prominin-1 relationship: RO:0002292 PR:000001932 ! expresses signal transducer CD24 relationship: RO:0002292 PR:000017298 ! expresses vimentin property_value: terms:date "2023-03-07T14:17:39Z" xsd:dateTime [Term] id: CL:4030039 name: von Economo neuron def: "An extratelencephalic-projecting glutamatergic cortical neuron that is morphologically-defined with a large, spindle-shaped cell body, thick bipolar dendrites with limited branching and a moderate density of spines, and often an axon initial segment that emanates from the side of the cell body. This cell type is associated with markers POU3F, BMP3 and ITGA4." [DOI:10.1007/BF02970950, DOI:10.1101/2022.10.12.511898, PMID:32127543] comment: In humans, a von Economo neuron is restricted to layer 5 of the anterior cingulate, frontoinsular, and medial frontopolar regions of cerebral cortex, while in some other species it is also found in the frontal and occipital poles and may not be restricted to layer 5. {xref="PMID:32127543"} subset: human_subset subset: mouse_subset synonym: "VEN" RELATED OMO:0003000 [PMID:32127543] is_a: CL:4023009 ! extratelencephalic-projecting glutamatergic cortical neuron relationship: RO:0000053 PATO:0070006 ! has characteristic cortical bipolar morphology property_value: terms:date "2023-05-25T07:29:21Z" xsd:dateTime [Term] id: CL:4030040 name: endometrial multiciliated epithelial cell def: "A multi-ciliated cell of the endometrial epithelium. This cell is characterized by the presence of 9+2 motile cilia on its apical surface, which facilitates the movement of mucus across the endometrial surface." [doi:10.1016/j.coemr.2024.100503, doi:10.1038/s41591-020-1040-z, https://www.proteinatlas.org/humanproteome/single+cell+type/Glandular+epithelial+cells#endometrialciliatedcells, PMID:31290979, PMID:37999981] comment: In human samples, the expression of FOXJ1 protein, a regulator for motile cilia with epithelial lineage identity, has been noted. {xref="ttps://www.nature.com/articles/s41591-020-1040-z"} subset: human_subset subset: mouse_subset synonym: "ciliated cell of the endometrium" EXACT [] synonym: "ciliated cell of the uterus" BROAD [] synonym: "endometrial ciliated epithelial cell" EXACT [] synonym: "endometrium ciliated epithelial cell" EXACT [] synonym: "uterine ciliated cell" BROAD [] is_a: CL:0002149 ! epithelial cell of uterus is_a: CL:0005012 ! multiciliated epithelial cell intersection_of: CL:0000075 ! columnar/cuboidal epithelial cell intersection_of: BFO:0000050 UBERON:0004811 ! part of endometrium epithelium intersection_of: BFO:0000051 GO:0097729 ! has part 9+2 motile cilium intersection_of: RO:0000053 PATO:0010007 ! has characteristic multiciliated relationship: BFO:0000050 UBERON:0004811 ! part of endometrium epithelium relationship: BFO:0000051 GO:0097729 ! has part 9+2 motile cilium property_value: terms:date "2023-02-09T11:25:14Z" xsd:dateTime [Term] id: CL:4030041 name: luminal endometrial multiciliated epithelial cell def: "A ciliated cell of the endometrial luminal epithelium. This cell is characterized by the presence of motile cilia on its apical surface." [doi:10.1038/s41591-020-1040-z] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "luminal endometrial ciliated epithelial cell" EXACT [] is_a: CL:4030040 ! endometrial multiciliated epithelial cell is_a: CL:4052050 ! luminal epithelial cell of endometrium property_value: terms:date "2023-02-09T11:34:42Z" xsd:dateTime [Term] id: CL:4030042 name: glandular endometrial multiciliated epithelial cell def: "A ciliated cell of the endometrial glandular epithelium. This cell is characterized by the presence of motile cilia on its apical surface." [doi:10.1038/s41591-020-1040-z] subset: human_subset subset: mouse_subset synonym: "glandular endometrial ciliated epithelial cell" EXACT [] is_a: CL:0009084 ! glandular epithelial cell of endometrium is_a: CL:4030040 ! endometrial multiciliated epithelial cell property_value: terms:date "2023-02-09T11:37:30Z" xsd:dateTime [Term] id: CL:4030043 name: matrix D1 medium spiny neuron def: "A DRD1-expressing medium spiny neuron that is part of a matrix compartment of dorsal striatum." [doi:10.1016/j.cub.2021.10.015] comment: In Rhesus macaques, both matrix D1 and D2 medium spiny neuron cell types have been noted to have enriched gene expression of the following: EPHA4, GDA, STXBP6, and SEMA3E. Broadly understood, matrix MSNs receive neocortical inputs from the associative and sensorimotor cortex and give rise to the direct and indirect pathways. {xref="doi:10.1016/j.cub.2021.10.015"} subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "D1-matrix" RELATED OMO:0003000 [doi:10.1016/j.cub.2021.10.015] synonym: "D1M" RELATED OMO:0003000 [doi:10.1016/j.cub.2021.10.015] synonym: "matrix D1-MSN" RELATED OMO:0003000 [doi:10.1016/j.cub.2021.10.015] is_a: CL:0002613 ! striatum neuron is_a: CL:4023026 ! direct pathway medium spiny neuron property_value: RO:0002175 NCBITaxon:9606 property_value: terms:date "2023-06-02T14:05:03Z" xsd:dateTime [Term] id: CL:4030047 name: matrix D2 medium spiny neuron def: "A DRD2-expressing medium spiny neuron that is part of a matrix compartment of dorsal striatum." [doi:10.1016/j.cub.2021.10.015] comment: In Rhesus macaques, both matrix D1 and D2 medium spiny neuron cell types have been noted to have enriched gene expression of the following: EPHA4, GDA, STXBP6, and SEMA3E. Broadly understood, matrix MSNs receive neocortical inputs from the associative and sensorimotor cortex and give rise to the direct and indirect pathways. {xref="doi:10.1016/j.cub.2021.10.015"} subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "D2-matrix" RELATED OMO:0003000 [doi:10.1016/j.cub.2021.10.015] synonym: "D2M" RELATED OMO:0003000 [doi:10.1016/j.cub.2021.10.015] synonym: "matrix D2-MSN" RELATED OMO:0003000 [doi:10.1016/j.cub.2021.10.015] is_a: CL:0002613 ! striatum neuron is_a: CL:4023029 ! indirect pathway medium spiny neuron property_value: RO:0002175 NCBITaxon:9606 property_value: terms:date "2023-06-02T14:40:25Z" xsd:dateTime [Term] id: CL:4030048 name: striosomal D1 medium spiny neuron def: "A DRD1-expressing medium spiny neuron that is part of a striosome of dorsal striatum." [doi:10.1016/j.cub.2021.10.015] comment: In Rhesus macaques, both striosomal D1 and D2 medium spiny neuron (MSN) cell types have been noted to have enriched gene expression of the following: KCNT1, KHDRBS3, FAM163A, BACH2, and KCNIP1. Striosomal MSN activations have been noted to influence cognitive and emotional decision making and value-based learning. In contrast to matrix MSNs, striosomal MSNs receive input from limbic territories, including the anterior cingulate cortex, orbitofrontal cortex, and anterior insular cortex, and project directly to midbrain dopamine neurons. {xref="doi:10.1016/j.cub.2021.10.015"} subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "D1-striosome" RELATED OMO:0003000 [DOI:10.1016/j.cub.2021.10.015] synonym: "D1S" RELATED OMO:0003000 [doi:10.1016/j.cub.2021.10.015] synonym: "striosome D1 medium spiny neuron" EXACT [doi:10.1016/j.cub.2021.10.015] synonym: "striosome D1-MSN" RELATED OMO:0003000 [doi:10.1016/j.cub.2021.10.015] is_a: CL:0002613 ! striatum neuron is_a: CL:4023026 ! direct pathway medium spiny neuron property_value: RO:0002175 NCBITaxon:9606 property_value: terms:date "2023-06-02T14:50:43Z" xsd:dateTime [Term] id: CL:4030049 name: striosomal D2 medium spiny neuron def: "A DRD2-expressing medium spiny neuron that is part of a striosome of dorsal striatum." [doi:10.1016/j.cub.2021.10.015] comment: In Rhesus macaques, both striosomal D1 and D2 medium spiny neuron (MSN) cell types have been noted to have enriched gene expression of the following: KCNT1, KHDRBS3, FAM163A, BACH2, and KCNIP1. Striosomal MSN activations have been noted to influence cognitive and emotional decision making and value-based learning. In contrast to matrix MSNs, striosomal MSNs receive input from limbic territories, including the anterior cingulate cortex, orbitofrontal cortex, and anterior insular cortex, and project directly to midbrain dopamine neurons. {xref="doi:10.1016/j.cub.2021.10.015"} subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "D2-striosome" RELATED OMO:0003000 [doi:10.1016/j.cub.2021.10.015] synonym: "D2S" RELATED OMO:0003000 [doi:10.1016/j.cub.2021.10.015] synonym: "striosome D2 medium spiny neuron" EXACT [doi:10.1016/j.cub.2021.10.015] synonym: "striosome D2-MSN" RELATED OMO:0003000 [doi:10.1016/j.cub.2021.10.015] is_a: CL:0002613 ! striatum neuron is_a: CL:4023029 ! indirect pathway medium spiny neuron property_value: RO:0002175 NCBITaxon:9606 property_value: terms:date "2023-06-02T15:03:08Z" xsd:dateTime [Term] id: CL:4030050 name: D1/D2-hybrid medium spiny neuron def: "A medium spiny neuron that expresses both DRD1 and DRD2 and is part of an extra-striosomal part of dorsal striatum." [doi:10.1016/j.cub.2021.10.015] comment: It has been noted in non-human primate species that the D1/D2-hybrid medium spiny neuron (D1/2) cell type shows the same amount of DRD1 expression as nearby D1 medium spiny neurons but far less DRD2 expression compared to nearby D2 medium spiny neurons. In Rhesus macaques, RXFP1 has been noted as a highly specific marker gene for the D1/2 cell type. The D1/2 cell type has also been described as having characteristics similar to a novel medium spiny neuron described in rodents (D1H or eccentric spiny projection neuron). Although an extrastriosomal cell type, the D1/2 cell type had been noted to express many of the genes associated with striosome, suggesting a possible homology to ‘‘exo-patch’’ cells. {xref="doi:10.1016/j.cub.2021.10.015"} subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "D1/2" RELATED OMO:0003000 [doi:10.1016/j.cub.2021.10.015] synonym: "D1/D2 hybrid" RELATED OMO:0003000 [doi:10.1016/j.cub.2021.10.015] synonym: "D1/D2-hybrid MSN" RELATED OMO:0003000 [doi:10.1016/j.cub.2021.10.015] synonym: "hybrid D1/2 cell type" RELATED OMO:0003000 [doi:10.1016/j.cub.2021.10.015] is_a: CL:0002613 ! striatum neuron is_a: CL:1001474 ! medium spiny neuron relationship: RO:0002100 UBERON:0005382 ! has soma location dorsal striatum relationship: RO:0002292 PR:000001175 ! expresses D(1A) dopamine receptor relationship: RO:0002292 PR:000001177 ! expresses D(2) dopamine receptor property_value: RO:0002175 NCBITaxon:9606 property_value: terms:date "2023-06-02T15:19:45Z" xsd:dateTime [Term] id: CL:4030051 name: nucleus accumbens shell and olfactory tubercle D1 medium spiny neuron def: "A DRD1-expressing medium spiny neuron that is part of a nucleus accumbens shell or olfactory tubercle." [doi:10.1016/j.cub.2021.10.015] comment: In Rhesus macaques, both nucleus accumbens shell and olfactory tubercle D1 and D2 medium spiny neuron cell types have been noted to have enriched gene expression of the following: GREB1L, ARHGAP6, and GRIA4. {xref="doi:10.1016/j.cub.2021.10.015"} subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "D1Sh" RELATED OMO:0003000 [doi:10.1016/j.cub.2021.10.015] synonym: "NAc shell and OT D1 medium spiny neuron" EXACT [doi:10.1016/j.cub.2021.10.015] synonym: "NAc shell and OT D1-MSN" RELATED OMO:0003000 [doi:10.1016/j.cub.2021.10.015] is_a: CL:0002613 ! striatum neuron is_a: CL:1001474 ! medium spiny neuron relationship: RO:0002100 UBERON:0005403 ! has soma location ventral striatum relationship: RO:0002292 PR:000001175 ! expresses D(1A) dopamine receptor property_value: RO:0002175 NCBITaxon:9606 property_value: terms:date "2023-06-14T13:03:50Z" xsd:dateTime [Term] id: CL:4030052 name: nucleus accumbens shell and olfactory tubercle D2 medium spiny neuron def: "A DRD2-expressing medium spiny neuron that is part of a nucleus accumbens shell or olfactory tubercle." [doi:10.1016/j.cub.2021.10.015] comment: In Rhesus macaques, both nucleus accumbens shell and olfactory tubercle D1 and D2 medium spiny neuron cell types have been noted to have enriched gene expression of the following: GREB1L, ARHGAP6, and GRIA4. {xref="doi:10.1016/j.cub.2021.10.015"} subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "D2Sh" RELATED OMO:0003000 [doi:10.1016/j.cub.2021.10.015] synonym: "NAc shell and OT D2 medium spiny neuron" EXACT [doi:10.1016/j.cub.2021.10.015] synonym: "NAc shell and OT D2-MSN" RELATED OMO:0003000 [doi:10.1016/j.cub.2021.10.015] synonym: "nucleus accumbens shell and olfactory tubercle D2-MSN" RELATED OMO:0003000 [doi:10.1016/j.cub.2021.10.015] is_a: CL:0002613 ! striatum neuron is_a: CL:1001474 ! medium spiny neuron relationship: RO:0002100 UBERON:0005403 ! has soma location ventral striatum relationship: RO:0002292 PR:000001177 ! expresses D(2) dopamine receptor property_value: RO:0002175 NCBITaxon:9606 property_value: terms:date "2023-06-14T13:27:51Z" xsd:dateTime [Term] id: CL:4030053 name: Islands of Calleja granule cell def: "A GABAergic neuron that resides in the islands of calleja and shows the cytoarchitectural and molecular features characteristic of this granule-like cell population. In mice and primates, it expresses D1 and D3 dopamine receptors (Drd1; Drd3), GABAergic markers (GAD1/2) and form densely packed granule cell clusters in the olfactory tubercle within the ventral striatum. Moreover it receives dense dopaminergic input from the VTA, and functionally associated with self-grooming behaviors and depression-like behaviors." [doi:10.1016/j.cub.2021.10.015, PMID:34795450, PMID:37898623] comment: In Rhesus macaques, the Island of Calleja granule cell type has been noted to have enriched gene expression of CPNE4. {xref="doi:10.1016/j.cub.2021.10.015"} subset: human_subset subset: mouse_subset synonym: "D1-ICj" RELATED OMO:0003000 [doi:10.1016/j.cub.2021.10.015] is_a: BFO:0000002 is_a: CL:0000120 ! granule cell is_a: CL:0000617 ! GABAergic neuron is_a: CL:0002613 ! striatum neuron relationship: RO:0002292 PR:000001175 ! expresses D(1A) dopamine receptor property_value: terms:contributor "https://orcid.org/0000-0002-5507-2103" xsd:string property_value: terms:date "2023-06-14T13:37:45Z" xsd:dateTime [Term] id: CL:4030054 name: D1-NUDAP medium spiny neuron def: "A DRD1-expressing medium spiny neuron that is part of dense, RXFP1-positive cell islands throughout the nucleus accumbens, putamen, and near the adjacent septal nuclei." [PMID:34727523] comment: Regarding the abbreviation D1-NUDAP, NUDAP stands for "neurochemically unique domains in the accumbens and putamen". In Rhesus macaques, the RXFP1-positive interface island D1-medium spiny neuron (D1-NUDAP) has been noted to have upregulation of OPRM1 compared to DRD1-expressing medium spiny neurons located outside of the D1-exclusive island and in Islands of Calleja. Kappa-opioid receptor gene (OPRK1) has been noted to be absent from D1-NUDAP cells. Many striosome-specific markers have been noted to be upregulated in D1-NUDAP cells, including KCNIP1, KCNT1, KHDRBS3, and BACH2. PDYN, an acknowledged D1-striosome marker gene, has also been noted to be expressed in D1-NUDAPs. D1-NUDAPs also express some genes found to be selectively expressed in the matrix, including STXBP6, GDA, and SEMA3E. Gene enrichment analysis has revealed that D1-NUDAP neurons express genes that have been implicated in drug addiction and many other functions. {xref="PMID:34727523"} subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "D1-NUDAP" RELATED OMO:0003000 [PMID:34727523] synonym: "RXFP1-positive interface island D1-medium spiny neuron" EXACT [PMID:34727523] is_a: CL:0002613 ! striatum neuron is_a: CL:1001474 ! medium spiny neuron relationship: RO:0002100 UBERON:0005403 ! has soma location ventral striatum relationship: RO:0002292 PR:000001175 ! expresses D(1A) dopamine receptor relationship: RO:0002292 PR:000001666 ! expresses relaxin receptor 1 property_value: IAO:0000028 "STRv D1 NUDAP MSN" xsd:string property_value: RO:0002175 NCBITaxon:9606 property_value: terms:date "2023-06-14T14:46:08Z" xsd:dateTime [Term] id: CL:4030055 name: intermediate cell of urothelium def: "A urothelial cell that is part of the regenerative layer(s) of cells directly superficial to basal cells in urothelium. The layer of intermediate cells in the urothelium ranges from one to several layers thick depending on the species with intermediate cells attached to adjacent cell layers and one another via desmosomes." [doi:10.1038/s41385-022-00565-0] comment: It has been noted in at least some mammalian species that the urothelial intermediate cell type is similar to basal cells by expressing CK17 and (unlike umbrella cells) p63 but is positive for uroplakins (UPK) and negative for CK5. Urothelial intermediate cells have also been noted to be larger in diameter than urothelial basal cells. {xref="doi:10.1038/s41385-022-00565-0"} subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "urothelial intermediate cell" EXACT [doi:10.1007/978-3-030-14366-4_8] xref: FMA:84155 is_a: CL:0000731 ! urothelial cell property_value: RO:0002175 NCBITaxon:9606 property_value: terms:contributor "https://orcid.org/0000-0003-3065-9183" xsd:string property_value: terms:date "2023-06-16T07:53:43Z" xsd:dateTime [Term] id: CL:4030056 name: umbrella cell of urothelium def: "A urothelial cell that is terminally differentiated and part of the urothelial apical surface that forms the high-resistance barrier of urothelium. Umbrella cells have been described as the largest of urothelial cell types, highly polarized, and, in some species, multinucleated. In the relaxed state, these cells form a dome-shaped structure at the apical pole and can also cover multiple underlying intermediate cells, leading to the name umbrella cells. In contrast, these cells flatten when the bladder is filled." [doi:10.1038/s41385-022-00565-0] comment: Umbrella cells are attached to sub-superficial cell layers via desmosomes, while tight junctions localized between superficial cells aid in forming a high-resistance barrier function. Another distinguishing feature of an umbrella cell type is the presence of subapical discoidal/fusiform-shaped vesicles contributing to the plasticity in urothelial cell surface area through a regulated process of endocytosis/exocytosis. It has been noted in at least some mammalian species that the urothelial umbrella cell type expresses UPK1A, UPK1B, UPK2 and UPK3A. Unlike intermediate and basal cells of the urothelium, CK17 is reported to be completely absent and p63 not expressed in umbrella cells. {xref="doi:10.1038/s41385-022-00565-0"} subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "facet cell of urothelium" EXACT [doi:10.1038/s41385-022-00565-0] synonym: "superficial cell of urothelium" EXACT [doi:10.1038/s41385-022-00565-0] xref: FMA:84149 is_a: CL:0000731 ! urothelial cell property_value: RO:0002175 NCBITaxon:9606 property_value: terms:contributor "https://orcid.org/0000-0003-3065-9183" xsd:string property_value: terms:date "2023-06-16T07:59:43Z" xsd:dateTime [Term] id: CL:4030057 name: eccentric medium spiny neuron def: "A medium spiny neuron that exhibits transcriptional divergence from direct and indirect spiny projection neurons, for example, enrichment in Casz1, Otof, Cacng5 and Pcdh8 noted in mice. Whilst in general medium spiny neurons have been found to be differentially distributed across the basal ganglia, the eccentric medium spiny neuron cell type has been found to be more evenly distributed throughout cerebral nuclei." [doi:10.1016/j.cell.2018.07.028, doi:10.1101/2022.10.12.511898] comment: The term “eccentric” is used in the name eccentric medium spiny neuron (MSN) due to the exhibited transcriptional divergence from canonical spiny projection neurons. It has been noted in at least one study that an eccentric MSN differs in expression from direct and indirect MSNs by 110 genes (more than the 68 that distinguished direct and indirect spiny projection neurons from each other) and expresses many genes that have little expression in the rest of the striatum. It also has been noted in at least one human study that most eccentric MSNs expressed only DRD1, but many in the basal ganglia co-expressed DRD1 and DRD2, suggesting regional specialization of a more broadly distributed cell type. {xref="doi:10.1101/2022.10.12.511898", xref="doi:10.1016/j.cell.2018.07.028"} subset: human_subset subset: mouse_subset synonym: "eccentric MSN" RELATED OMO:0003000 [doi:10.1101/2022.10.12.511898] synonym: "eccentric spiny projection neuron" EXACT [doi:10.1016/j.cell.2018.07.028] synonym: "eccentric SPN" RELATED OMO:0003000 [doi:10.1016/j.cell.2018.07.028] synonym: "eSPN" RELATED OMO:0003000 [doi:10.1016/j.cell.2018.07.028] is_a: CL:1001474 ! medium spiny neuron property_value: terms:date "2023-06-23T14:59:36Z" xsd:dateTime [Term] id: CL:4030058 name: TCR-positive macrophage def: "A macrophage that expresses the T cell receptor complex at the cell surface." [https://orcid.org/0000-0001-9990-8331, PMID:26074923] subset: human_subset subset: mouse_subset synonym: "T cell receptor positive macrophage" EXACT [PMID:26074923] synonym: "TCR+ macrophage" EXACT [PMID:26074923] synonym: "TCR.macs" RELATED [PMID:37500727] {synonymtypedef="OMO:0003000"} is_a: CL:0000235 ! macrophage intersection_of: CL:0000235 ! macrophage intersection_of: RO:0002104 GO:0042101 ! has plasma membrane part T cell receptor complex relationship: RO:0002104 GO:0042101 ! has plasma membrane part T cell receptor complex property_value: terms:contributor https://orcid.org/0000-0003-3308-6245 property_value: terms:date "2023-09-26T12:27:14Z" xsd:dateTime [Term] id: CL:4030059 name: L2/3 intratelencephalic projecting glutamatergic neuron def: "A transcriptomically distinct intratelencephalic-projecting glutamatergic neuron with a soma found between cortical layer 2-4. This intratelencephalic-projecting glutamatergic neuron has thin-tufted apical dendrites and extends its axonal projection into L5 in the neocortex. This neuronal type has a hyperpolarised resting membrane potential." [https://cellxgene.cziscience.com/e/c3aa4f95-7a18-4a7d-8dd8-ca324d714363.cxg/, PMID:25622573, PMID:34004146, PMID:37292694, PMID:37824655] comment: Hystorically, the L2/3 intratelencephalic projectic glutametergic neuron was known to have its soma in cortical layer 2/3. MERFISH data showed that this intratelencephalic-projecting glutametergic neuron can have its soma in layer 2/3, 4B, 4C. The position of the soma in layer 4b and 4C is less frequent for this neuronal type in comparison to cortical layer 2/3. The marker set ONECUT2, COL5A2 can identify the Human cell type L2/3 intratelencephalic projecting glutamatergic neuron in the neocortex with a confidence of 0.670149932 (NS-Forest FBeta value). {xref="https://doi.org/10.5281/zenodo.11165918", xref="PMID:37824655"} subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "L2/3 IT" RELATED OMO:0003000 [PMID:34004146] xref: ILX:0770156 is_a: CL:4023040 ! L2/3-6 intratelencephalic projecting glutamatergic neuron intersection_of: CL:4023040 ! L2/3-6 intratelencephalic projecting glutamatergic neuron intersection_of: RO:0002100 UBERON:8440000 ! has soma location cortical layer II/III relationship: RO:0002100 UBERON:8440000 ! has soma location cortical layer II/III relationship: RO:0015004 CLM:1000065 ! has characterizing marker set NS forest marker set of L2/3 intratelencephalic projecting glutamatergic neuron (Human neocortex). property_value: IAO:0000028 "L2/3 IT" xsd:string property_value: RO:0002175 NCBITaxon:9606 property_value: terms:contributor https://orcid.org/0000-0003-4389-9821 property_value: terms:date "2023-10-10T14:10:21Z" xsd:dateTime [Term] id: CL:4030060 name: L2 intratelencephalic projecting glutamatergic neuron def: "An intratelencephalic-projecting glutamatergic neuron with a soma found in cortical layer 2." [PMID:34004146] subset: human_subset subset: mouse_subset synonym: "L2 IT" RELATED OMO:0003000 [PMID:34004146] is_a: CL:4023040 ! L2/3-6 intratelencephalic projecting glutamatergic neuron intersection_of: CL:4023040 ! L2/3-6 intratelencephalic projecting glutamatergic neuron intersection_of: RO:0002100 UBERON:0005391 ! has soma location cortical layer II relationship: RO:0002100 UBERON:0005391 ! has soma location cortical layer II property_value: IAO:0000028 "L2 IT" xsd:string property_value: terms:contributor https://orcid.org/0000-0003-4389-9821 property_value: terms:date "2023-10-10T14:10:36Z" xsd:dateTime [Term] id: CL:4030061 name: L3 intratelencephalic projecting glutamatergic neuron def: "An intratelencephalic-projecting glutamatergic neuron with a soma found in cortical layer 3." [PMID:34004146] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "L3 IT" RELATED OMO:0003000 [PMID:34004146] is_a: CL:4023040 ! L2/3-6 intratelencephalic projecting glutamatergic neuron intersection_of: CL:4023040 ! L2/3-6 intratelencephalic projecting glutamatergic neuron intersection_of: RO:0002100 UBERON:0005392 ! has soma location cortical layer III relationship: RO:0002100 UBERON:0005392 ! has soma location cortical layer III property_value: IAO:0000028 "L3 IT" xsd:string property_value: terms:contributor https://orcid.org/0000-0003-4389-9821 property_value: terms:date "2023-10-10T14:10:47Z" xsd:dateTime [Term] id: CL:4030062 name: L4/5 intratelencephalic projecting glutamatergic neuron def: "An intratelencephalic-projecting glutamatergic with a soma located in cortical layer 4/5." [PMID:34004146] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "L4/5 IT" RELATED OMO:0003000 [PMID:34004146] is_a: CL:4023040 ! L2/3-6 intratelencephalic projecting glutamatergic neuron intersection_of: CL:4023040 ! L2/3-6 intratelencephalic projecting glutamatergic neuron intersection_of: RO:0002100 UBERON:8440001 ! has soma location cortical layer IV/V relationship: RO:0002100 UBERON:8440001 ! has soma location cortical layer IV/V property_value: IAO:0000028 "L4/5 IT" xsd:string property_value: terms:contributor https://orcid.org/0000-0003-4389-9821 property_value: terms:date "2023-10-10T14:11:04Z" xsd:dateTime [Term] id: CL:4030063 name: L4 intratelencephalic projecting glutamatergic neuron def: "A transcriptomically distinct intratelencephalic-projecting glutamatergic neuron with a soma found in cortical layer 3-4. This neuron type can have a pyramidal, star-pyramidal or spiny stellate morphology and projects its output to L2/3 and L5A/B." [https://cellxgene.cziscience.com/e/c3aa4f95-7a18-4a7d-8dd8-ca324d714363.cxg/, PMID:37292694, PMID:37824655] comment: Historically, the L4 intratelencephalic projectic glutametergic neuron was known to have its soma in cortical layer 4. MERFISH data showed that this intratelencephalic-projecting glutametergic neuron can also have its soma in layer 3. The marker set RORB, ST8SIA4 can identify the Human cell type L4 intratelencephalic projecting glutamatergic neuron in the neocortex with a confidence of 0.720108696 (NS-Forest FBeta value). {xref="https://doi.org/10.5281/zenodo.11165918"} subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "L4 IT" RELATED OMO:0003000 [PMID:37292694] is_a: CL:4023040 ! L2/3-6 intratelencephalic projecting glutamatergic neuron intersection_of: CL:4023040 ! L2/3-6 intratelencephalic projecting glutamatergic neuron intersection_of: RO:0002100 UBERON:0005393 ! has soma location cortical layer IV relationship: RO:0002100 UBERON:0005393 ! has soma location cortical layer IV relationship: RO:0015004 CLM:1000066 ! has characterizing marker set NS forest marker set of L4 intratelencephalic projecting glutamatergic neuron (Human neocortex). property_value: IAO:0000028 "L4 IT" xsd:string property_value: RO:0002175 NCBITaxon:9606 property_value: terms:contributor https://orcid.org/0000-0003-4389-9821 property_value: terms:date "2023-10-10T14:11:25Z" xsd:dateTime [Term] id: CL:4030064 name: L5 intratelencephalic projecting glutamatergic neuron def: "An intratelencephalic-projecting glutamatergic neuron with a soma found in cortical layer 5." [https://cellxgene.cziscience.com/e/c3aa4f95-7a18-4a7d-8dd8-ca324d714363.cxg/, PMID:37292694, PMID:37609206, PMID:37824655] comment: The marker set ARSJ, RORB, KCNK2 can identify the Human cell type L5 intratelencephalic projecting glutamatergic neuron in the neocortex with a confidence of 0.764261336 (NS-Forest FBeta value). {xref="https://doi.org/10.5281/zenodo.11165918"} subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "L5 IT" RELATED [PMID:37292694] {synonymtypedef="OMO:0003000"} xref: ILX:0770157 is_a: CL:4023040 ! L2/3-6 intratelencephalic projecting glutamatergic neuron intersection_of: CL:4023040 ! L2/3-6 intratelencephalic projecting glutamatergic neuron intersection_of: RO:0002100 UBERON:0005394 ! has soma location cortical layer V relationship: RO:0002100 UBERON:0005394 ! has soma location cortical layer V relationship: RO:0015004 CLM:1000068 ! has characterizing marker set NS forest marker set of L5 intratelencephalic projecting glutamatergic neuron (Human neocortex). property_value: IAO:0000028 "L5 IT" xsd:string property_value: RO:0002175 NCBITaxon:9606 property_value: terms:contributor https://orcid.org/0000-0003-4389-9821 property_value: terms:date "2023-10-10T14:11:59Z" xsd:dateTime [Term] id: CL:4030065 name: L6 intratelencephalic projecting glutamatergic neuron def: "A transcriptomically distinct intratelencephalic-projecting glutamatergic neuron with a soma found in L6 of the primary motor cortex. These cells are short untufted pyramidal cells, which could be stellate or inverted." [https://cellxgene.cziscience.com/e/c3aa4f95-7a18-4a7d-8dd8-ca324d714363.cxg/, PMID:37292694, PMID:37609206, PMID:37824655] comment: The marker set LINC00507, THEMIS can identify the Human cell type L6 intratelencephalic projecting glutamatergic neuron in the neocortex with a confidence of 0.641695703 (NS-Forest FBeta value). {xref="https://doi.org/10.5281/zenodo.11165918"} subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "L6 IT" RELATED OMO:0003000 [PMID:37292694] xref: ILX:0770158 is_a: CL:4023040 ! L2/3-6 intratelencephalic projecting glutamatergic neuron intersection_of: CL:4023040 ! L2/3-6 intratelencephalic projecting glutamatergic neuron intersection_of: RO:0002100 UBERON:0005395 ! has soma location cortical layer VI relationship: RO:0002100 UBERON:0005395 ! has soma location cortical layer VI relationship: RO:0015004 CLM:1000071 ! has characterizing marker set NS forest marker set of L6 intratelencephalic projecting glutamatergic neuron (Human neocortex). property_value: IAO:0000028 "L6 IT" xsd:string property_value: RO:0002175 NCBITaxon:9606 property_value: terms:contributor https://orcid.org/0000-0003-4389-9821 property_value: terms:date "2023-10-10T14:12:23Z" xsd:dateTime [Term] id: CL:4030066 name: ureteric bud cell def: "An epithelial cell that is part of a ureteric bud. A ureteric bud cell has the potential to induce metanephric mesenchymal cells to proliferate and convert to epithelia that form renal tubules via: (1) the secretion of multiple diffusible growth factors that rescue renal progenitors from apoptosis and stimulate them to proliferate and (2) contact-dependent mechanisms that induce mesenchymal-epithelial conversion." [PMID:17133361, PMID:24183650, PMID:9374839] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "UB cell" RELATED OMO:0003000 [PMID:24183650] is_a: BFO:0000002 is_a: CL:0000068 ! duct epithelial cell is_a: CL:0002518 ! kidney epithelial cell intersection_of: CL:0000066 ! epithelial cell intersection_of: BFO:0000050 UBERON:0000084 ! part of ureteric bud relationship: BFO:0000050 UBERON:0000084 ! part of ureteric bud relationship: RO:0000056 GO:2001013 {xref="PMID:9374839"} ! participates in epithelial cell proliferation involved in renal tubule morphogenesis property_value: terms:contributor "https://orcid.org/0000-0002-1425-877X" xsd:string property_value: terms:date "2023-10-13T11:22:42Z" xsd:dateTime [Term] id: CL:4030067 name: L5/6 near-projecting glutamatergic neuron def: "A transcriptomically defined near-projecting glutamatergic neuron with a soma found in cortical layer 5/6." [PMID:34004146, PMID:37292694, PMID:37824655] comment: The marker set NPSR1-AS1, TLL1 can identify the Human cell type L5/6 near-projecting glutamatergic neuron in the neocortex with a confidence of 0.899288218 (NS-Forest FBeta value). {xref="https://doi.org/10.5281/zenodo.11165918"} subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "L5/6 NP" RELATED OMO:0003000 [PMID:34004146] is_a: CL:4023012 ! near-projecting glutamatergic cortical neuron intersection_of: CL:4023012 ! near-projecting glutamatergic cortical neuron intersection_of: RO:0002100 UBERON:8440002 ! has soma location cortical layer V/VI relationship: RO:0002100 UBERON:8440002 ! has soma location cortical layer V/VI relationship: RO:0015004 CLM:1000069 ! has characterizing marker set NS forest marker set of L5/6 near-projecting glutamatergic neuron (Human neocortex). property_value: RO:0002175 NCBITaxon:9606 property_value: terms:contributor https://orcid.org/0000-0003-4389-9821 property_value: terms:date "2023-11-17T11:35:06Z" xsd:dateTime [Term] id: CL:4030068 name: L6 intratelencephalic projecting Car3 glutamatergic neuron def: "A transcriptomically distinct intratelencepalic-projecting glutamatergic neuron that expresses Car3 with a soma found in L6." [doi:10.1007/s00424-024-02923-2, doi:10.1101/2022.11.30.518285, PMID:34004146, PMID:37824655] comment: The marker set SMYD1, THEMIS can identify the Human cell type L6 intratelencephalic projecting Car3 glutamatergic neuron in the neocortex with a confidence of 0.877752028 (NS-Forest FBeta value). {xref="https://doi.org/10.5281/zenodo.11165918"} subset: human_subset subset: mouse_subset synonym: "L6 IT Car3" RELATED OMO:0003000 [doi:10.1101/2022.11.06.515349] synonym: "L6 IT Car3 glutamatergic neuron" EXACT OMO:0003000 [doi:10.1101/2022.11.06.515349] synonym: "L6 IT Car3 neuron" RELATED OMO:0003000 [PMID:37824655] synonym: "L6-IT-Car3" RELATED OMO:0003000 [doi:10.1101/2022.11.30.518285] synonym: "L6-IT-Car3 cell" RELATED OMO:0003000 [PMID:37824655] is_a: BFO:0000002 is_a: CL:4030065 ! L6 intratelencephalic projecting glutamatergic neuron intersection_of: CL:4023040 ! L2/3-6 intratelencephalic projecting glutamatergic neuron intersection_of: RO:0002100 UBERON:0005395 ! has soma location cortical layer VI intersection_of: RO:0002292 PR:000004919 ! expresses carbonic anhydrase 3 relationship: RO:0002292 PR:000004919 ! expresses carbonic anhydrase 3 relationship: RO:0015004 CLM:1000072 ! has characterizing marker set NS forest marker set of L6 intratelencephalic projecting Car3 glutamatergic neuron (Human neocortex). property_value: IAO:0000028 "L6 IT Car3" xsd:string property_value: RO:0002175 NCBITaxon:9606 property_value: terms:contributor https://orcid.org/0000-0003-4389-9821 property_value: terms:date "2023-11-23T09:16:14Z" xsd:dateTime [Term] id: CL:4032000 name: club-like cell of the urethral epithelium def: "An epithelial cell of the urethra that has an expression profile similar to lung club cells. Club-like cells of the urethra epithelium are similar to lung club cells in their expression of SCGB1A1 and in their enrichment of immunomodulatory programs." [PMID:30566875, PMID:32497356] comment: Club cells typically refer to bronchiolar exocrine cells found in the lungs. This cell type is given the name club cell due to their similarity to club cells in the lungs. {xref="PMID:30566875"} subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "club cell of the urethra epithelium" EXACT [] synonym: "club-like cell of the prostatic urethra epithelium" EXACT [https://orcid.org/0000-0001-7258-9596] synonym: "prostate club cell" EXACT [PMID:30566875] is_a: BFO:0000002 is_a: CL:1000296 ! epithelial cell of urethra relationship: RO:0002292 PR:000014505 ! expresses uteroglobin property_value: IAO:0000116 "The term \"club-like\" is used to disambiguate from club cells which CL defines as a type of bronchial epithelial cell. This seems to reflect common usage of club cell when used without location (club cell seems to mean bronchial club cell, unless it is proceded or preceded by something that says it is not bronchial). In the literature, the name \"club-like\" isn't used." xsd:string property_value: terms:contributor http://orcid.org/0000-0001-6757-4744 [Term] id: CL:4032001 name: reelin GABAergic cortical interneuron def: "A GABAergic interneuron located in the cerebral cortex that expresses reelin (rln)." [PMID:23803971] subset: human_subset subset: mouse_subset synonym: "rln GABAergic cortical interneuron" EXACT [PMID:29904965] is_a: BFO:0000002 is_a: CL:0010011 ! cerebral cortex GABAergic interneuron intersection_of: CL:0000099 ! interneuron intersection_of: RO:0002100 UBERON:0000956 ! has soma location cerebral cortex intersection_of: RO:0002215 GO:0061534 ! capable of gamma-aminobutyric acid secretion, neurotransmission intersection_of: RO:0002292 PR:000013879 ! expresses reelin relationship: RO:0002292 PR:000013879 ! expresses reelin property_value: terms:contributor "http://orcid.org/0000-0001-5501-853X" xsd:string property_value: terms:contributor http://orcid.org/0000-0001-6757-4744 property_value: terms:contributor "http://orcid.org/0000-0001-7476-6306" xsd:string [Term] id: CL:4033000 name: endothelial cell of venule of lymph node def: "A(n) endothelial cell that is part of a(n) venule of lymph node." [PMID:28217126] subset: human_subset subset: mouse_subset is_a: CL:1000414 ! endothelial cell of venule intersection_of: CL:0000115 ! endothelial cell intersection_of: BFO:0000050 UBERON:8410041 ! part of venule of lymph node relationship: BFO:0000050 UBERON:8410041 ! part of venule of lymph node property_value: terms:contributor https://orcid.org/0000-0001-6677-8489 [Term] id: CL:4033001 name: endothelial cell of arteriole of lymph node def: "A(n) endothelial cell that is part of a(n) arteriole of lymph node." [PMID:28217126] subset: human_subset subset: mouse_subset is_a: CL:1000412 ! endothelial cell of arteriole intersection_of: CL:0000115 ! endothelial cell intersection_of: BFO:0000050 UBERON:8410042 ! part of arteriole of lymph node relationship: BFO:0000050 UBERON:8410042 ! part of arteriole of lymph node property_value: terms:contributor https://orcid.org/0000-0001-6677-8489 [Term] id: CL:4033002 name: neuroendocrine cell of epithelium of crypt of Lieberkuhn def: "A(n) neuroendocrine cell that is part of a(n) epithelium of crypt of Lieberkuhn." [PMID:31390635] subset: human_subset subset: mouse_subset is_a: CL:0000150 ! glandular secretory epithelial cell is_a: CL:0000165 ! neuroendocrine cell is_a: CL:1001516 ! intestinal enteroendocrine cell intersection_of: CL:0000165 ! neuroendocrine cell intersection_of: BFO:0000050 UBERON:0011184 ! part of epithelium of crypt of Lieberkuhn relationship: BFO:0000050 UBERON:0011184 ! part of epithelium of crypt of Lieberkuhn property_value: terms:contributor https://orcid.org/0000-0001-6677-8489 [Term] id: CL:4033003 name: myoepithelial cell of bronchus submucosal gland def: "A(n) myoepithelial cell that is part of a(n) bronchus submucosal gland." [PMID:19996346, PMID:5487122] subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset is_a: CL:0000185 ! myoepithelial cell is_a: CL:0002328 ! bronchial epithelial cell intersection_of: CL:0000185 ! myoepithelial cell intersection_of: BFO:0000050 UBERON:8410043 ! part of bronchus submucosal gland relationship: BFO:0000050 UBERON:8410043 ! part of bronchus submucosal gland property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/2d-ftu/lung-bronchial-submucosal-gland/v1.2/assets/2d-ftu-lung-bronchial-submucosal-gland.png" xsd:string {terms:licence="http://creativecommons.org/licenses/by/4.0/", xref="doi:10.48539/HBM656.TJVD.294"} property_value: RO:0002175 NCBITaxon:9606 property_value: terms:contributor https://orcid.org/0000-0001-6677-8489 [Term] id: CL:4033004 name: smooth muscle cell of taenia coli def: "A(n) smooth muscle cell that is part of a(n) taenia coli." [PMID:10715339, PMID:22320805] subset: human_subset subset: mouse_subset is_a: CL:1000279 ! smooth muscle cell of large intestine intersection_of: CL:0000192 ! smooth muscle cell intersection_of: BFO:0000050 UBERON:0012419 ! part of taenia coli relationship: BFO:0000050 UBERON:0001278 ! part of epithelium of large intestine relationship: BFO:0000050 UBERON:0012419 ! part of taenia coli property_value: terms:contributor https://orcid.org/0000-0001-6677-8489 [Term] id: CL:4033005 name: serous secreting cell of bronchus submucosal gland def: "A(n) serous secreting cell that is part of a(n) bronchus submucosal gland." [PMID:5487122, PMID:9651178] comment: The marker set PRR4, C6orf58 can identify the Human cell type serous secreting cell of bronchus submucosal gland in the lung with a confidence of 0.75 (NS-Forest FBeta value). {xref="https://doi.org/10.5281/zenodo.11165918"} subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset is_a: CL:0000152 ! exocrine cell is_a: CL:0019001 ! tracheobronchial serous cell intersection_of: CL:0000313 ! serous secreting cell intersection_of: BFO:0000050 UBERON:8410043 ! part of bronchus submucosal gland relationship: BFO:0000050 UBERON:8410043 ! part of bronchus submucosal gland relationship: RO:0015004 CLM:1000054 ! has characterizing marker set NS forest marker set of serous secreting cell of bronchus submucosal gland (Human lung). property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/2d-ftu/lung-bronchial-submucosal-gland/v1.2/assets/2d-ftu-lung-bronchial-submucosal-gland.png" xsd:string {terms:licence="http://creativecommons.org/licenses/by/4.0/", xref="doi:10.48539/HBM656.TJVD.294"} property_value: RO:0002175 NCBITaxon:9606 property_value: terms:contributor https://orcid.org/0000-0001-6677-8489 [Term] id: CL:4033006 name: endothelial cell of efferent lymphatic vessel def: "A(n) endothelial cell that is part of a(n) efferent lymphatic vessel." [PMID:32094869] subset: human_subset subset: mouse_subset is_a: CL:0002138 ! endothelial cell of lymphatic vessel intersection_of: CL:0000115 ! endothelial cell intersection_of: BFO:0000050 UBERON:0010397 ! part of efferent lymphatic vessel relationship: BFO:0000050 UBERON:0010397 ! part of efferent lymphatic vessel property_value: terms:contributor https://orcid.org/0000-0001-6677-8489 [Term] id: CL:4033007 name: brush cell of epithelium of lobar bronchus def: "A(n) brush cell that is part of a(n) epithelium of lobar bronchus." [PMID:15817800] subset: human_reference_atlas subset: human_subset subset: mouse_subset is_a: CL:0000082 ! epithelial cell of lung is_a: CL:0002208 ! brush cell of bronchus intersection_of: CL:0002204 ! tuft cell intersection_of: BFO:0000050 UBERON:0002339 ! part of epithelium of lobar bronchus relationship: BFO:0000050 UBERON:0002339 ! part of epithelium of lobar bronchus property_value: RO:0002175 NCBITaxon:9606 property_value: terms:contributor https://orcid.org/0000-0001-6677-8489 [Term] id: CL:4033008 name: vein endothelial cell of respiratory system def: "A(n) vein endothelial cell that is part of a(n) respiratory system." [PMID:34030460] subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset is_a: CL:0002543 ! vein endothelial cell intersection_of: CL:0002543 ! vein endothelial cell intersection_of: BFO:0000050 UBERON:0001004 ! part of respiratory system relationship: BFO:0000050 UBERON:0001004 ! part of respiratory system property_value: RO:0002175 NCBITaxon:9606 property_value: terms:contributor https://orcid.org/0000-0001-6677-8489 [Term] id: CL:4033009 name: goblet cell of epithelium of lobar bronchus def: "A(n) goblet cell that is part of a(n) epithelium of lobar bronchus." [PMID:18757316] subset: human_reference_atlas subset: human_subset subset: mouse_subset is_a: CL:1000143 ! lung goblet cell is_a: CL:1000312 ! bronchial goblet cell intersection_of: CL:0000160 ! goblet cell intersection_of: BFO:0000050 UBERON:0002339 ! part of epithelium of lobar bronchus relationship: BFO:0000050 UBERON:0002339 ! part of epithelium of lobar bronchus property_value: RO:0002175 NCBITaxon:9606 property_value: terms:contributor https://orcid.org/0000-0001-6677-8489 [Term] id: CL:4033010 name: neuroendocrine cell of epithelium of lobar bronchus def: "A(n) neuroendocrine cell that is part of a(n) epithelium of lobar bronchus." [PMID:26711336, PMID:33355253] subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset is_a: CL:0000082 ! epithelial cell of lung is_a: CL:0002328 ! bronchial epithelial cell is_a: CL:0008055 ! respiratory tract secretory epithelial cell is_a: CL:1000223 ! pulmonary neuroendocrine cell intersection_of: CL:0000165 ! neuroendocrine cell intersection_of: BFO:0000050 UBERON:0002339 ! part of epithelium of lobar bronchus relationship: BFO:0000050 UBERON:0002339 ! part of epithelium of lobar bronchus property_value: RO:0002175 NCBITaxon:9606 property_value: terms:contributor https://orcid.org/0000-0001-6677-8489 [Term] id: CL:4033011 name: smooth muscle cell of large intestine smooth muscle circular layer def: "A(n) smooth muscle cell that is part of a(n) large intestine smooth muscle circular layer." [PMID:24997029] subset: human_subset subset: mouse_subset is_a: CL:1000279 ! smooth muscle cell of large intestine intersection_of: CL:0000192 ! smooth muscle cell intersection_of: BFO:0000050 UBERON:0012398 ! part of large intestine smooth muscle circular layer relationship: BFO:0000050 UBERON:0001278 ! part of epithelium of large intestine relationship: BFO:0000050 UBERON:0012398 ! part of large intestine smooth muscle circular layer property_value: terms:contributor https://orcid.org/0000-0001-6677-8489 [Term] id: CL:4033012 name: smooth muscle cell of large intestine smooth muscle longitudinal layer def: "A(n) smooth muscle cell that is part of a(n) large intestine smooth muscle longitudinal layer." [PMID:24997029] subset: human_subset subset: mouse_subset is_a: CL:1000279 ! smooth muscle cell of large intestine intersection_of: CL:0000192 ! smooth muscle cell intersection_of: BFO:0000050 UBERON:0012399 ! part of large intestine smooth muscle longitudinal layer relationship: BFO:0000050 UBERON:0001278 ! part of epithelium of large intestine relationship: BFO:0000050 UBERON:0012399 ! part of large intestine smooth muscle longitudinal layer property_value: terms:contributor https://orcid.org/0000-0001-6677-8489 [Term] id: CL:4033013 name: suprabasal keratinocyte def: "A keratinocyte that resides in the epidermal suprabasal layer and expresses differentiation markers, including keratin 1 and keratin 10, in both humans and mice. In human interfollicular epidermis, this cell retains proliferative capacity and possesses retrodifferentiation potential, acquiring basal-like properties during wound healing or basement membrane contact." [https://www.proteinatlas.org/humanproteome/single+cell+type/squamous+epithelial+cells#suprabasalkeratinocytes, PMID:22375063, PMID:35883599, PMID:9520465] subset: cellxgene_subset subset: human_subset subset: mouse_subset is_a: CL:4052061 ! epidermal keratinocyte is_a: CL:7770004 ! suprabasal cell intersection_of: CL:0000312 ! keratinocyte intersection_of: BFO:0000050 UBERON:0010402 ! part of epidermis suprabasal layer relationship: BFO:0000050 UBERON:0010402 ! part of epidermis suprabasal layer property_value: terms:contributor http://orcid.org/0000-0001-6677-8489 creation_date: 2023-02-02T11:17:04Z [Term] id: CL:4033014 name: peg cell def: "A small, narrow, peg-shaped epithelial cell with little cytoplasm that is part of oviduct epithelium. This cell is rarer than the ciliated and secretory epithelial cells of the fallopian tube epithelium and is often found intercalated between them. Peg cells are generally distributed basally along the epithelium and have been found in high concentrations at the fimbriated, distal end of the fallopian tube in humans. It may have a regenerative/stem-cell function. In humans, markers include EPCAM, CD44, and ITGA6." [PMID:2210508, PMID:22911892, PMID:30023181] comment: In vitro evidence supports a stem-cell/regenerative function for these cells {xref="PMID:22911892"} subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "fallopian tube epithelial stem-like cell" EXACT [PMID:22911892] synonym: "FTE stem-like cell" EXACT [PMID:22911892] synonym: "FTESC" EXACT OMO:0003000 [PMID:22911892] synonym: "intercalary cell" EXACT [PMID:22911892] is_a: CL:4052019 ! fallopian tube non-ciliated epithelial cell relationship: BFO:0000050 UBERON:0004804 ! part of oviduct epithelium property_value: RO:0002175 NCBITaxon:9606 property_value: terms:contributor https://orcid.org/0000-0001-6677-8489 property_value: terms:date "2023-02-02T15:07:12Z" xsd:dateTime [Term] id: CL:4033015 name: retinal astrocyte def: "A star-shaped glial cell that is part of some retina. This cell links neurons to blood vessels and may provide structural and physiological support to optic nerve head axons." [PMID:25236977, PMID:33796062] comment: In response to elevated intraocular pressure, a retinal astrocyte may modulate extracellular matrix remodeling. In the human retina, a retinal astrocyte is GFAP-positive, SOD3-positive and GYPC-positive. {xref="PMID:33796062", xref="PMID:32555229"} subset: cellxgene_subset subset: eye_upper_slim subset: human_subset subset: mouse_subset synonym: "retinal astroglia" RELATED OMO:0003004 [PMID:33796062] is_a: CL:0000127 ! astrocyte is_a: CL:0009004 ! retinal cell intersection_of: CL:0000127 ! astrocyte intersection_of: BFO:0000050 UBERON:0000966 ! part of retina relationship: BFO:0000050 UBERON:0000966 ! part of retina property_value: terms:contributor https://orcid.org/0000-0001-6677-8489 property_value: terms:date "2023-03-02T14:38:32Z" xsd:dateTime [Term] id: CL:4033016 name: secondary crest myofibroblast def: "A myofibroblast that is part of an alveoli during alveolarization. The contractile force of this cell elongates the secondary crest, while producing a framework of elastin and tenascin. During the maturation of the septa, secondary crest myofibroblasts, together with matrix fibroblasts, secrete metalloproteinases and other ECM‐remodeling proteins to thin the septal tip ECM. The secondary crest myofibroblast continues producing elastin, eventually undergoing apoptosis during adulthood." [PMID:31331942, PMID:33624948] subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "alveolar myofibroblast" RELATED [PMID:31331942] synonym: "SCMF" RELATED OMO:0003000 [PMID:33624948] synonym: "SCMFs" RELATED OMO:0003004 [PMID:25448080] synonym: "secondary-crest myofibroblast" EXACT [PMID:31331942] is_a: BFO:0000002 is_a: CL:0000186 ! myofibroblast cell relationship: BFO:0000050 UBERON:0000114 ! part of lung connective tissue relationship: RO:0000056 GO:0048286 ! participates in lung alveolus development property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/2d-ftu/lung-pulmonary-alveolus/v1.3/assets/2d-ftu-lung-pulmonary-alveolus.png" xsd:string {terms:licence="http://creativecommons.org/licenses/by/4.0/", xref="doi:10.48539/HBM558.BZLS.992"} property_value: RO:0002175 NCBITaxon:9606 property_value: terms:contributor https://orcid.org/0000-0001-6677-8489 property_value: terms:contributor https://orcid.org/0000-0002-9185-3994 property_value: terms:date "2023-03-16T09:17:47Z" xsd:dateTime [Term] id: CL:4033017 name: bronchiolar smooth muscle cell def: "A smooth muscle cell that is part of a bronchiole." [ISBN:9781260462982, PMID:15347627] subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset is_a: CL:0019019 ! tracheobronchial smooth muscle cell intersection_of: CL:0000192 ! smooth muscle cell intersection_of: BFO:0000050 UBERON:0002186 ! part of bronchiole relationship: BFO:0000050 UBERON:0004515 ! part of smooth muscle tissue of bronchiole property_value: RO:0002175 NCBITaxon:9606 property_value: terms:contributor https://orcid.org/0000-0001-6677-8489 property_value: terms:contributor https://orcid.org/0000-0002-9185-3994 property_value: terms:date "2023-03-16T09:38:17Z" xsd:dateTime [Term] id: CL:4033018 name: lung megakaryocyte def: "A megakaryocyte that is resident in the lung connective tissue." [PMID:33351116] subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "lung MKs" RELATED OMO:0003004 [PMID:33351116] synonym: "lung resident megakaryocyte" EXACT [PMID:36524131] synonym: "lung-resident megakaryocyte" EXACT [PMID:36524131] synonym: "MKL" RELATED OMO:0003000 [PMID:36524131] is_a: CL:0000556 ! megakaryocyte is_a: CL:0002320 ! connective tissue cell intersection_of: CL:0000556 ! megakaryocyte intersection_of: BFO:0000050 UBERON:0000114 ! part of lung connective tissue relationship: BFO:0000050 UBERON:0000114 ! part of lung connective tissue property_value: RO:0002175 NCBITaxon:9606 property_value: terms:contributor https://orcid.org/0000-0001-6677-8489 property_value: terms:contributor https://orcid.org/0000-0002-9185-3994 property_value: terms:date "2023-03-16T11:31:23Z" xsd:dateTime [Term] id: CL:4033019 name: ON-blue cone bipolar cell def: "An ON bipolar cell type with dendrites selectively contacting S-cones." [PMID:32032773] comment: The axons of a blue cone bipolar cell terminate close to the ganglion cell layer, where they transfer the S-cone ON signal to small bistratified ganglion cells. Other targets of a blue cone bipolar cell include amacrine cells and possibly large bistratified ganglion cells. The marker set SORCS3, TAFA1 can identify the Human cell type http://purl.obolibrary.org/obo/CL_4033019 in the retina with a confidence of 0.709302326 (NS-Forest FBeta value). The marker set TAFA1, ENSG00000250971 can identify the Human cell type http://purl.obolibrary.org/obo/CL_4033019 in the retina with a confidence of 0.797269292 (NS-Forest FBeta value). {xref="https://doi.org/10.5281/zenodo.11165918", xref="PMID:32032773"} subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "BB cell" RELATED OMO:0003000 [PMID:32032773] is_a: CL:0000749 ! ON-bipolar cell relationship: RO:0015004 CLM:1001250 ! has characterizing marker set NS forest marker set of ON-blue cone bipolar cell (Human retina). relationship: RO:0015004 CLM:1001259 ! has characterizing marker set NS forest marker set of ON-blue cone bipolar cell (Human retina). property_value: RO:0002175 NCBITaxon:9606 property_value: terms:contributor https://orcid.org/0000-0001-6677-8489 property_value: terms:date "2023-04-04T09:48:15Z" xsd:dateTime [Term] id: CL:4033020 name: mucus secreting cell of trachea gland def: "A mucus secreting cell that is part of a submucosal gland of the trachea." [PMID:18931053, PMID:29656943] subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "tracheal submucosal gland mucous cell" EXACT [PMID:18931053] is_a: CL:0000307 ! tracheal epithelial cell is_a: CL:4033037 ! mucus secreting cell of tracheobronchial tree submucosal gland intersection_of: CL:0000319 ! mucus secreting cell intersection_of: BFO:0000050 UBERON:0005203 ! part of trachea gland relationship: BFO:0000050 UBERON:0005203 ! part of trachea gland property_value: RO:0002175 NCBITaxon:9606 property_value: terms:contributor https://orcid.org/0000-0001-6677-8489 property_value: terms:contributor https://orcid.org/0000-0002-9185-3994 property_value: terms:date "2023-03-16T13:03:13Z" xsd:dateTime [Term] id: CL:4033021 name: myoepithelial cell of trachea gland def: "A myoepithelial cell that is part of a submucosal gland of the trachea." [PMID:29656943] subset: human_reference_atlas subset: human_subset subset: mouse_subset is_a: CL:0000185 ! myoepithelial cell is_a: CL:0000307 ! tracheal epithelial cell intersection_of: CL:0000185 ! myoepithelial cell intersection_of: BFO:0000050 UBERON:0005203 ! part of trachea gland relationship: BFO:0000050 UBERON:0005203 ! part of trachea gland property_value: RO:0002175 NCBITaxon:9606 property_value: terms:contributor https://orcid.org/0000-0001-6677-8489 property_value: terms:contributor https://orcid.org/0000-0002-9185-3994 property_value: terms:date "2023-03-16T13:36:43Z" xsd:dateTime [Term] id: CL:4033022 name: mucus secreting cell of bronchus submucosal gland def: "A mucus secreting cell of a submucosal gland of the bronchus." [PMID:19965983] comment: The marker set BPIFB2 can identify the Human cell type mucus secreting cell of bronchus submucosal gland in the lung with a confidence of 0.93 (NS-Forest FBeta value). {xref="https://doi.org/10.5281/zenodo.11165918"} subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "bronchial gland mucous cell" EXACT [PMID:5487122] is_a: CL:0002328 ! bronchial epithelial cell is_a: CL:4033037 ! mucus secreting cell of tracheobronchial tree submucosal gland intersection_of: CL:0000319 ! mucus secreting cell intersection_of: BFO:0000050 UBERON:8410043 ! part of bronchus submucosal gland relationship: BFO:0000050 UBERON:8410043 ! part of bronchus submucosal gland relationship: RO:0015004 CLM:1000053 ! has characterizing marker set NS forest marker set of mucus secreting cell of bronchus submucosal gland (Human lung). property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/2d-ftu/lung-bronchial-submucosal-gland/v1.2/assets/2d-ftu-lung-bronchial-submucosal-gland.png" xsd:string {terms:licence="http://creativecommons.org/licenses/by/4.0/", xref="doi:10.48539/HBM656.TJVD.294"} property_value: RO:0002175 NCBITaxon:9606 property_value: terms:contributor https://orcid.org/0000-0001-6677-8489 property_value: terms:contributor https://orcid.org/0000-0002-9185-3994 property_value: terms:date "2023-03-16T15:12:52Z" xsd:dateTime [Term] id: CL:4033023 name: airway submucosal gland collecting duct epithelial cell def: "An epithelial cell that is part of a collecting duct of an airway submucosal gland." [PMID:25648514, PMID:29656943] comment: The marker set GLYATL2, DMBT1 can identify the Human cell type airway submucosal gland collecting duct epithelial cell in the lung with a confidence of 0.46 (NS-Forest FBeta value). {xref="https://doi.org/10.5281/zenodo.11165918"} subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset is_a: CL:0000066 ! epithelial cell relationship: BFO:0000050 UBERON:8410077 ! part of airway submucosal gland relationship: RO:0015004 CLM:1000052 ! has characterizing marker set NS forest marker set of airway submucosal gland collecting duct epithelial cell (Human lung). property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/2d-ftu/lung-bronchial-submucosal-gland/v1.2/assets/2d-ftu-lung-bronchial-submucosal-gland.png" xsd:string {terms:licence="http://creativecommons.org/licenses/by/4.0/", xref="doi:10.48539/HBM656.TJVD.294"} property_value: RO:0002175 NCBITaxon:9606 property_value: terms:contributor https://orcid.org/0000-0001-6677-8489 property_value: terms:contributor https://orcid.org/0000-0002-9185-3994 property_value: terms:date "2023-03-16T15:20:28Z" xsd:dateTime [Term] id: CL:4033024 name: airway submucosal gland duct basal cell def: "A basal cell that is part of a duct of an airway submucosal gland." [PMID:29656943, PMID:35046051] subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset is_a: CL:0000646 ! basal cell relationship: BFO:0000050 UBERON:8410077 ! part of airway submucosal gland property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/2d-ftu/lung-bronchial-submucosal-gland/v1.2/assets/2d-ftu-lung-bronchial-submucosal-gland.png" xsd:string {terms:licence="http://creativecommons.org/licenses/by/4.0/", xref="doi:10.48539/HBM656.TJVD.294"} property_value: RO:0002175 NCBITaxon:9606 property_value: terms:contributor https://orcid.org/0000-0001-6677-8489 property_value: terms:contributor "https://orcid.org/0000-0002-9185-3994" xsd:string property_value: terms:date "2023-03-16T15:51:39Z" xsd:dateTime [Term] id: CL:4033025 name: perichondrial fibroblast def: "A fibroblast that is part of the fibrous layer of the perichondrium. This cell is responsible for collagen fiber production." [wikipedia:Perichondrium] subset: human_reference_atlas subset: human_subset subset: mouse_subset is_a: CL:0000057 ! fibroblast intersection_of: CL:0000057 ! fibroblast intersection_of: BFO:0000050 UBERON:0008305 ! part of outer fibrous layer of perichondrium relationship: BFO:0000050 UBERON:0008305 ! part of outer fibrous layer of perichondrium property_value: RO:0002175 NCBITaxon:9606 property_value: terms:contributor https://orcid.org/0000-0001-6677-8489 property_value: terms:contributor https://orcid.org/0000-0002-9185-3994 property_value: terms:date "2023-03-16T16:12:50Z" xsd:dateTime [Term] id: CL:4033026 name: lung perichondrial fibroblast def: "A perichondrial fibroblast that is part of the lung." [PMID:36543915] subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "PC-fibro" RELATED OMO:0003000 [PMID:36543915] is_a: CL:0002553 ! fibroblast of lung is_a: CL:4033025 ! perichondrial fibroblast intersection_of: CL:4033025 ! perichondrial fibroblast intersection_of: BFO:0000050 UBERON:0002048 ! part of lung property_value: RO:0002175 NCBITaxon:9606 property_value: terms:contributor https://orcid.org/0000-0001-6677-8489 property_value: terms:contributor https://orcid.org/0000-0002-9185-3994 property_value: terms:date "2023-03-16T16:15:39Z" xsd:dateTime [Term] id: CL:4033027 name: diffuse bipolar 1 cell def: "An OFF diffuse bipolar cell that makes synaptic contact with both L/M and S-cone photoreceptors and only minimal contact with rod photoreceptors." [PMID:22006647] comment: In primates, a diffuse bipolar 1 cell on average makes 81 ribbon (output) synapses, 13 contacts are with OFF parasol cells and 47 contacts are with OFF midget cells. This cell might make flat contacts at both triad-associated and non-triad-associated positions on the cone pedicle. The marker set LAMA3, EBF1 can identify the Human cell type http://purl.obolibrary.org/obo/CL_4033027 in the retina with a confidence of 0.917474411 (NS-Forest FBeta value). The marker set NXPH2, EBF1 can identify the Human cell type http://purl.obolibrary.org/obo/CL_4033027 in the retina with a confidence of 0.752547687 (NS-Forest FBeta value). {xref="https://doi.org/10.5281/zenodo.11165918", xref="PMID:22006647", xref="PMID:32032773"} subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "DB1 bipolar" RELATED OMO:0003000 [PMID:22006647] synonym: "DB1 bipolar cell" RELATED OMO:0003000 [PMID:22006647] synonym: "DB1 cell" RELATED OMO:0003000 [PMID:32032773] synonym: "Diffuse Bipolar Cell Type DB1" EXACT [PMID:22006647] is_a: CL:0000750 ! OFF-bipolar cell relationship: RO:0015004 CLM:1001243 ! has characterizing marker set NS forest marker set of diffuse bipolar 1 cell (Human retina). relationship: RO:0015004 CLM:1001254 ! has characterizing marker set NS forest marker set of diffuse bipolar 1 cell (Human retina). property_value: RO:0002175 NCBITaxon:9606 property_value: terms:contributor https://orcid.org/0000-0001-6677-8489 property_value: terms:date "2023-04-04T10:48:29Z" xsd:dateTime [Term] id: CL:4033028 name: diffuse bipolar 2 cell def: "An OFF diffuse bipolar cell that predominantly connects to ON parasol cells and lateral amacrine cells. This cell contains a large number of synaptic ribbons and a small axon arbor area." [PMID:25309346, PMID:26500507, PMID:27833534] comment: In primates, a diffuse bipolar 2 cell makes an average of 133 ribbon synapses, 47 contacts are with OFF parasol cells and 4 contacts are with OFF midget cells. The marker set ENSG00000243004, ENSG00000249803 can identify the Human cell type http://purl.obolibrary.org/obo/CL_4033028 in the retina with a confidence of 0.770513807 (NS-Forest FBeta value). The marker set TAFA4, DSCAM can identify the Human cell type http://purl.obolibrary.org/obo/CL_4033028 in the retina with a confidence of 0.886091243 (NS-Forest FBeta value). {xref="https://doi.org/10.5281/zenodo.11165918", xref="PMID:32032773"} subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "DB2 cell" RELATED OMO:0003000 [PMID:32032773] is_a: CL:0000750 ! OFF-bipolar cell relationship: RO:0015004 CLM:1001245 ! has characterizing marker set NS forest marker set of diffuse bipolar 2 cell (Human retina). relationship: RO:0015004 CLM:1001258 ! has characterizing marker set NS forest marker set of diffuse bipolar 2 cell (Human retina). property_value: RO:0002175 NCBITaxon:9606 property_value: terms:contributor https://orcid.org/0000-0001-6677-8489 property_value: terms:date "2023-04-04T10:49:07Z" xsd:dateTime [Term] id: CL:4033029 name: diffuse bipolar 3a cell def: "An OFF calbindin-positive bipolar cell that has a large dendritic field and stratifies narrowly close to the middle of the inner plexiform layer. Its axon terminal is characterized by regularly branching and varicose processes resembling beads on a string. Most of DB3a contacts with cones are triad-associated." [PMID:32032773, PMID:32555229, PMID:33009001] comment: Originally, DB3a cells were termed diffuse bipolar 3 (DB3) cells. When an additional bipolar type which stratifies slightly more vitread and is calbindin negative was detected, this cell was renamed diffuse bipolar 3a cell. The axons of neighboring DB3a cells make homologous gap junctions. The DB3a cells provide the majority of their output to OFF parasol cells. The marker set ENSG00000267109 can identify the Human cell type http://purl.obolibrary.org/obo/CL_4033029 in the retina with a confidence of 0.848827502 (NS-Forest FBeta value). The marker set ERBB4 can identify the Human cell type http://purl.obolibrary.org/obo/CL_4033029 in the retina with a confidence of 0.949243066 (NS-Forest FBeta value). {xref="https://doi.org/10.5281/zenodo.11165918", xref="DOI:10.3389/fnana.2015.00122", xref="PMID:32032773"} subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "DB3 cell" RELATED OMO:0003000 [DOI:10.3389/fnana.2015.00122] synonym: "DB3a cell" RELATED OMO:0003000 [PMID:32032773] is_a: CL:0000750 ! OFF-bipolar cell relationship: RO:0015004 CLM:1001249 ! has characterizing marker set NS forest marker set of diffuse bipolar 3a cell (Human retina). relationship: RO:0015004 CLM:1001260 ! has characterizing marker set NS forest marker set of diffuse bipolar 3a cell (Human retina). property_value: RO:0002175 NCBITaxon:9606 property_value: terms:contributor https://orcid.org/0000-0001-6677-8489 property_value: terms:date "2023-04-04T10:53:33Z" xsd:dateTime [Term] id: CL:4033030 name: diffuse bipolar 3b cell def: "An OFF calbindin-negative bipolar cell that has a large dendritic field and stratifies narrowly close to the middle of the inner plexiform layer. Its axon terminal is characterized by regularly branching and varicose processes resembling beads on a string. Most of DB3b contacts with cones are non-triad-associated." [PMID:32032773, PMID:32555229] comment: In humans, a DB3b cell is CD15 positive. A DB3b cell might make sparse contacts to rod photoreceptors. The marker set ABCA4, DPP10 can identify the Human cell type http://purl.obolibrary.org/obo/CL_4033030 in the retina with a confidence of 0.765019652 (NS-Forest FBeta value). The marker set MEIS2, ENSG00000242021 can identify the Human cell type http://purl.obolibrary.org/obo/CL_4033030 in the retina with a confidence of 0.821782012 (NS-Forest FBeta value). {xref="PMID:24107939", xref="PMID:33009001", xref="https://doi.org/10.5281/zenodo.11165918", xref="PMID:32032773"} subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "DB3b cell" RELATED OMO:0003000 [PMID:32032773] is_a: CL:0000750 ! OFF-bipolar cell relationship: RO:0015004 CLM:1001242 ! has characterizing marker set NS forest marker set of diffuse bipolar 3b cell (Human retina). relationship: RO:0015004 CLM:1001253 ! has characterizing marker set NS forest marker set of diffuse bipolar 3b cell (Human retina). property_value: RO:0002175 NCBITaxon:9606 property_value: terms:contributor https://orcid.org/0000-0001-6677-8489 property_value: terms:date "2023-04-04T10:53:42Z" xsd:dateTime [Term] id: CL:4033031 name: diffuse bipolar 4 cell def: "An ON diffuse bipolar cell that predominantly connects to ON parasol cells and lateral amacrine cells." [PMID:27833534, PMID:32032773, PMID:32555229] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "DB4 cell" RELATED OMO:0003000 [PMID:32032773] is_a: CL:0000749 ! ON-bipolar cell property_value: terms:contributor https://orcid.org/0000-0001-6677-8489 property_value: terms:date "2023-04-04T09:51:10Z" xsd:dateTime [Term] id: CL:4033032 name: diffuse bipolar 6 cell def: "An ON diffuse bipolar cell that has a large dendritic field and large axon terminals, which show little or no overlap. This cell predominantly connects to narrow thorny ganglion cells." [PMID:32032773, PMID:32555229] comment: The marker set ENSG00000275443 can identify the Human cell type http://purl.obolibrary.org/obo/CL_4033032 in the retina with a confidence of 0.817444508 (NS-Forest FBeta value). The marker set ENSG00000275443 can identify the Human cell type http://purl.obolibrary.org/obo/CL_4033032 in the retina with a confidence of 0.877512571 (NS-Forest FBeta value). {xref="https://doi.org/10.5281/zenodo.11165918"} subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "DB6 cell" RELATED OMO:0003000 [PMID:32032773] is_a: CL:0000749 ! ON-bipolar cell relationship: RO:0015004 CLM:1001244 ! has characterizing marker set NS forest marker set of diffuse bipolar 6 cell (Human retina). relationship: RO:0015004 CLM:1001257 ! has characterizing marker set NS forest marker set of diffuse bipolar 6 cell (Human retina). property_value: RO:0002175 NCBITaxon:9606 property_value: terms:contributor https://orcid.org/0000-0001-6677-8489 property_value: terms:date "2023-04-04T09:51:22Z" xsd:dateTime [Term] id: CL:4033033 name: flat midget bipolar cell def: "An OFF bipolar cell with a small dendritic tree that provides most of the triad-associated basal (flat) contacts at cone pedicles." [PMID:32032773, PMID:32555229] comment: The marker set NKAIN3, TAFA4 can identify the Human cell type http://purl.obolibrary.org/obo/CL_4033033 in the retina with a confidence of 0.915774104 (NS-Forest FBeta value). The marker set SCG2, TAFA4 can identify the Human cell type http://purl.obolibrary.org/obo/CL_4033033 in the retina with a confidence of 0.891115106 (NS-Forest FBeta value). {xref="https://doi.org/10.5281/zenodo.11165918"} subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "FMB cell" RELATED OMO:0003000 [PMID:32032773] is_a: CL:0000750 ! OFF-bipolar cell relationship: RO:0015004 CLM:1001247 ! has characterizing marker set NS forest marker set of flat midget bipolar cell (Human retina). relationship: RO:0015004 CLM:1001262 ! has characterizing marker set NS forest marker set of flat midget bipolar cell (Human retina). property_value: RO:0002175 NCBITaxon:9606 property_value: terms:contributor https://orcid.org/0000-0001-6677-8489 property_value: terms:date "2023-04-04T10:54:00Z" xsd:dateTime [Term] id: CL:4033034 name: invaginating midget bipolar cell def: "An ON bipolar cell with a small dendritic tree that forms most of the central (invaginating) elements opposite the synaptic ribbon at the cone triad." [PMID:32032773, PMID:32555229] comment: The marker set PTPRT, CARMIL1 can identify the Human cell type http://purl.obolibrary.org/obo/CL_4033034 in the retina with a confidence of 0.80078521 (NS-Forest FBeta value). The marker set RELN, ENSG00000271860 can identify the Human cell type http://purl.obolibrary.org/obo/CL_4033034 in the retina with a confidence of 0.884807812 (NS-Forest FBeta value). {xref="https://doi.org/10.5281/zenodo.11165918"} subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "IMB cell" RELATED OMO:0003000 [PMID:32032773] is_a: CL:0000749 ! ON-bipolar cell relationship: RO:0015004 CLM:1001252 ! has characterizing marker set NS forest marker set of invaginating midget bipolar cell (Human retina). relationship: RO:0015004 CLM:1001264 ! has characterizing marker set NS forest marker set of invaginating midget bipolar cell (Human retina). property_value: RO:0002175 NCBITaxon:9606 property_value: terms:contributor https://orcid.org/0000-0001-6677-8489 property_value: terms:date "2023-04-04T09:51:44Z" xsd:dateTime [Term] id: CL:4033035 name: giant bipolar cell def: "An ON bipolar cell that has large dendritic and axonal fields." [PMID:32032773, PMID:32555229] comment: A giant bipolar cell is usually monostratified, although, very rarely, it can be bistratified. The marker set UTRN can identify the Human cell type http://purl.obolibrary.org/obo/CL_4033035 in the retina with a confidence of 0.808459341 (NS-Forest FBeta value). The marker set UTRN, NTRK3 can identify the Human cell type http://purl.obolibrary.org/obo/CL_4033035 in the retina with a confidence of 0.725035162 (NS-Forest FBeta value). {xref="https://doi.org/10.5281/zenodo.11165918", xref="PMID:32032773"} subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "GB cell" RELATED OMO:0003000 [PMID:32032773] is_a: CL:0000749 ! ON-bipolar cell relationship: RO:0015004 CLM:1001248 ! has characterizing marker set NS forest marker set of giant bipolar cell (Human retina). relationship: RO:0015004 CLM:1001265 ! has characterizing marker set NS forest marker set of giant bipolar cell (Human retina). property_value: RO:0002175 NCBITaxon:9606 property_value: terms:contributor https://orcid.org/0000-0001-6677-8489 property_value: terms:date "2023-04-04T09:54:15Z" xsd:dateTime [Term] id: CL:4033036 name: OFFx cell def: "An OFF bipolar cell that is fovea-specific and expresses FEZF1, NXPH1 and NXPH2." [PMID:30712875, PMID:31995762, PMID:32555229] comment: The marker set ARHGAP6, ENSG00000278254 can identify the Human cell type http://purl.obolibrary.org/obo/CL_4033036 in the retina with a confidence of 0.785018957 (NS-Forest FBeta value). The marker set ENSG00000278254, ERBB4 can identify the Human cell type http://purl.obolibrary.org/obo/CL_4033036 in the retina with a confidence of 0.722779636 (NS-Forest FBeta value). {xref="https://doi.org/10.5281/zenodo.11165918"} subset: cellxgene_subset subset: human_subset subset: mouse_subset is_a: CL:0000750 ! OFF-bipolar cell relationship: BFO:0000050 UBERON:0001786 ! part of fovea centralis relationship: RO:0015004 CLM:1001240 ! has characterizing marker set NS forest marker set of OFFx cell (Human retina). relationship: RO:0015004 CLM:1001255 ! has characterizing marker set NS forest marker set of OFFx cell (Human retina). property_value: RO:0002175 NCBITaxon:9443 property_value: RO:0002175 NCBITaxon:9606 property_value: terms:contributor https://orcid.org/0000-0001-6677-8489 property_value: terms:date "2023-04-04T10:54:15Z" xsd:dateTime [Term] id: CL:4033037 name: mucus secreting cell of tracheobronchial tree submucosal gland def: "A mucus secreting cell of a submucosal gland of the tracheobronchial tree." [PMID:30864819] subset: cellxgene_subset subset: human_subset subset: mouse_subset is_a: CL:0000150 ! glandular secretory epithelial cell is_a: CL:0000152 ! exocrine cell is_a: CL:0000319 ! mucus secreting cell is_a: CL:0002202 ! epithelial cell of tracheobronchial tree is_a: CL:0008055 ! respiratory tract secretory epithelial cell intersection_of: CL:0000319 ! mucus secreting cell intersection_of: BFO:0000050 UBERON:0007196 ! part of tracheobronchial tree intersection_of: BFO:0000050 UBERON:8410077 ! part of airway submucosal gland relationship: BFO:0000050 UBERON:8410077 ! part of airway submucosal gland property_value: terms:contributor https://orcid.org/0000-0001-6677-8489 property_value: terms:date "2023-04-20T10:55:50Z" xsd:dateTime [Term] id: CL:4033038 name: lung resident memory CD4-positive, alpha-beta T cell def: "An alpha-beta CD4 T cell that resides in the lung." [PMID:24064670, PMID:31265968] subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "lung CD4-positive TRM" RELATED OMO:0003000 [PMID:31265968] synonym: "lung resident memory CD4 T cell" EXACT [PMID:24064670] is_a: CL:0000897 ! CD4-positive, alpha-beta memory T cell relationship: BFO:0000050 UBERON:0002048 ! part of lung property_value: RO:0002175 NCBITaxon:9606 property_value: terms:contributor https://orcid.org/0000-0001-6677-8489 property_value: terms:contributor https://orcid.org/0000-0002-9185-3994 property_value: terms:date "2023-04-27T10:15:45Z" xsd:dateTime [Term] id: CL:4033039 name: lung resident memory CD8-positive, alpha-beta T cell def: "An alpha-beta CD8 T cell that resides in the lung." [PMID:28418771, PMID:31265968] comment: In the lung, CXCR6 regulates the localization of lung resident memory CD8-positive, alpha-beta T cells. {xref="PMID:31558615"} subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "lung CD8-positive TRM" RELATED OMO:0003000 [PMID:31265968] is_a: CL:0000909 ! CD8-positive, alpha-beta memory T cell relationship: BFO:0000050 UBERON:0002048 ! part of lung property_value: RO:0002175 NCBITaxon:9606 property_value: terms:contributor https://orcid.org/0000-0001-6677-8489 property_value: terms:contributor https://orcid.org/0000-0002-9185-3994 property_value: terms:date "2023-04-27T10:16:07Z" xsd:dateTime [Term] id: CL:4033040 name: lung resident memory CD8-positive, CD103-positive, alpha-beta T cell def: "A lung resident memory CD8-positive, alpha-beta T cell that is CD103-positive." [PMID:27776108] subset: human_subset subset: mouse_subset synonym: "lung resident memory CD8-positive CD103-positive, alpha-beta T cell" EXACT [PMID:27776108] synonym: "lung TRM CD8-positive, CD103-positive cell" EXACT [PMID:27776108] synonym: "lung TRM CD8-positive, integrin alpha E-positive cell" EXACT [PMID:27776108] is_a: CL:4033039 ! lung resident memory CD8-positive, alpha-beta T cell intersection_of: CL:4033039 ! lung resident memory CD8-positive, alpha-beta T cell intersection_of: RO:0002104 PR:000001010 ! has plasma membrane part integrin alpha-E relationship: RO:0002104 PR:000001010 ! has plasma membrane part integrin alpha-E property_value: terms:contributor https://orcid.org/0000-0001-6677-8489 property_value: terms:contributor https://orcid.org/0000-0002-9185-3994 property_value: terms:date "2023-05-24T12:23:35Z" xsd:dateTime [Term] id: CL:4033041 name: CCL3-positive alveolar macrophage def: "An alveolar macrophage that expresses CCL3." [PMID:37291214] comment: The marker set TNIP3, CXCL5 can identify the Human cell type CCL3-positive alveolar macrophage in the lung with a confidence of 0.67 (NS-Forest FBeta value). {xref="https://doi.org/10.5281/zenodo.11165918"} subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "alveolar macrophage CCL3-positive" EXACT [PMID:37291214] is_a: CL:0000583 ! alveolar macrophage relationship: RO:0002292 PR:000002123 ! expresses C-C motif chemokine 3 relationship: RO:0015004 CLM:1000004 ! has characterizing marker set NS forest marker set of CCL3-positive alveolar macrophage (Human lung). property_value: RO:0002175 NCBITaxon:9606 property_value: terms:contributor https://orcid.org/0000-0001-6677-8489 property_value: terms:contributor https://orcid.org/0000-0002-9185-3994 property_value: terms:date "2023-06-15T12:53:08Z" xsd:dateTime [Term] id: CL:4033042 name: metallothionein-positive alveolar macrophage def: "An alveolar macrophage that expresses metallothionein." [PMID:37291214] comment: The marker set HMOX1, HPGD can identify the Human cell type metallothionein-positive alveolar macrophage in the lung with a confidence of 0.41 (NS-Forest FBeta value). {xref="https://doi.org/10.5281/zenodo.11165918"} subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "alveolar macrophage metallothionein-positive" EXACT [PMID:37291214] synonym: "alveolar macrophage MT-positive" EXACT [PMID:37291214] is_a: CL:0000583 ! alveolar macrophage relationship: RO:0015004 CLM:1000005 ! has characterizing marker set NS forest marker set of metallothionein-positive alveolar macrophage (Human lung). property_value: RO:0002175 NCBITaxon:9606 property_value: terms:contributor https://orcid.org/0000-0001-6677-8489 property_value: terms:contributor https://orcid.org/0000-0002-9185-3994 property_value: terms:date "2023-06-15T12:55:34Z" xsd:dateTime [Term] id: CL:4033043 name: lung interstitial macrophage def: "A macrophage that is part of the lung connective tissue (pulmonary interstitium). This cell performs tissue remodeling and contributes to barrier immunity through antigen presentation." [PMID:33382972, PMID:35017701, PMID:36211428] comment: The marker set F13A1, STAB1, FCGR2B can identify the Human cell type lung interstitial macrophage in the lung with a confidence of 0.46 (NS-Forest FBeta value). {xref="https://doi.org/10.5281/zenodo.11165918"} subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "lung IM" RELATED OMO:0003000 [PMID:36211428] is_a: CL:0000864 ! tissue-resident macrophage is_a: CL:0002320 ! connective tissue cell is_a: CL:1001603 ! lung macrophage relationship: BFO:0000050 UBERON:0000114 ! part of lung connective tissue relationship: RO:0015004 CLM:1000031 ! has characterizing marker set NS forest marker set of lung interstitial macrophage (Human lung). property_value: RO:0002175 NCBITaxon:9606 property_value: terms:contributor https://orcid.org/0000-0001-6677-8489 property_value: terms:contributor https://orcid.org/0000-0002-9185-3994 property_value: terms:date "2023-06-15T12:58:11Z" xsd:dateTime [Term] id: CL:4033044 name: deuterosomal cell def: "An epithelial cell part of respiratory tract epithelium that is a precursor of a multi-ciliated cell. This cell actively amplifies centrioles, a required step for multiciliogenesis." [PMID:31558434, PMID:331922198, PMID:36883528, PMID:37291214] comment: In humans, deuterosomal cells have been noted to have enriched expression of the following: PLK4, FOXJ1, DEUP1, FOXN4, YPEL1, HES6 and CDC20B. Deuterosomal cells were termed after deuterosomes, the platforms of active centriole amplification. {xref="PMID:31558434", xref="PMID:36883528", xref="PMID:331922198"} subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset is_a: CL:0002368 ! respiratory tract epithelial cell relationship: RO:0002215 GO:0098535 ! capable of de novo centriole assembly involved in multi-ciliated epithelial cell differentiation property_value: RO:0002175 NCBITaxon:9606 property_value: terms:contributor https://orcid.org/0000-0001-6677-8489 property_value: terms:contributor https://orcid.org/0000-0002-9185-3994 property_value: terms:date "2023-06-20T10:27:17Z" xsd:dateTime [Term] id: CL:4033045 name: lung migratory dendritic cell def: "A dendritic cell that captures antigens in a lung and migrates to a lymph node or to the spleen to activate T cells." [PMID:34516781] subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "lung mDC" RELATED OMO:0003000 [PMID:34516781] synonym: "lung mDCs" RELATED OMO:0003004 [PMID:34516781] is_a: CL:0000451 ! dendritic cell property_value: RO:0002175 NCBITaxon:9606 property_value: terms:contributor https://orcid.org/0000-0001-6677-8489 property_value: terms:contributor https://orcid.org/0000-0002-9185-3994 property_value: terms:date "2023-06-21T10:04:46Z" xsd:dateTime [Term] id: CL:4033046 name: ON midget ganglion cell def: "A midget ganglion cell that depolarizes in response to increased light intensity in the center of its receptive field. The majority of input that this cell receives comes from invaginating midget bipolar cells." [PMID:32032773] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "inner stratifying midget cell" EXACT [PMID:32032773] synonym: "ON-midget cell" EXACT [PMID:34093409] synonym: "ON-midget RGC" EXACT [PMID:34093409] is_a: CL:4023032 ! ON retinal ganglion cell is_a: CL:4023188 ! midget ganglion cell of retina intersection_of: CL:4023032 ! ON retinal ganglion cell intersection_of: CL:4023188 ! midget ganglion cell of retina property_value: terms:contributor https://orcid.org/0000-0001-6677-8489 property_value: terms:date "2023-08-08T09:40:08Z" xsd:dateTime [Term] id: CL:4033047 name: OFF midget ganglion cell def: "A midget ganglion cell that depolarizes in response to decreased light intensity in the center of its receptive field. The majority of input that this cell receives comes from flat midget bipolar cells." [PMID:32032773] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "OFF-midget cell" EXACT [PMID:34093409] synonym: "OFF-midget RGC" EXACT [PMID:34093409] synonym: "outer stratifying midget cell" EXACT [PMID:32032773] is_a: CL:4023033 ! OFF retinal ganglion cell is_a: CL:4023188 ! midget ganglion cell of retina intersection_of: CL:4023033 ! OFF retinal ganglion cell intersection_of: CL:4023188 ! midget ganglion cell of retina property_value: terms:contributor https://orcid.org/0000-0001-6677-8489 property_value: terms:date "2023-08-08T11:05:37Z" xsd:dateTime [Term] id: CL:4033048 name: respiratory tract suprabasal cell def: "A respiratory epithelial cell derived from a basal cell, with a topographic nuclear position between the basal and luminal cells of the airway epithelium. This non-basal, intermediate progenitor cell has limited proliferative capacity and can differentiate into multiciliated, secretory, or rare airway cells (ionocytes, tuft cells, neuroendocrine cells). It shares some ultrastructural features with basal cells but lacks the defined characteristics of fully differentiated cellular phenotypes." [PMID:25564622, PMID:34044844, PMID:35387001, PMID:37834236] comment: In humans, respiratory tract suprabasal cells have been noted to have enriched expression of the following: CK8, KRT13, IVL, and SERPINB3. Single-cell sequencing indicates that suprabasal cells derived from the nasal epithelium are distinct from those in the tracheobronchial epithelium. The marker set TNC, KRT15, SERPINB4 can identify the Human cell type respiratory tract suprabasal cell in the lung with a confidence of 0.62 (NS-Forest FBeta value). {xref="PMID:25658372", xref="PMID:32726565", xref="doi:10.1101/2023.04.20.537495", xref="https://doi.org/10.5281/zenodo.11165918"} subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "respiratory parabasal cell" EXACT [PMID:25564622] synonym: "respiratory suprabasal cell" EXACT [] synonym: "respiratory suprabasal progenitor cell" EXACT [PMID:25658372] is_a: CL:0002368 ! respiratory tract epithelial cell is_a: CL:0011026 ! progenitor cell is_a: CL:7770004 ! suprabasal cell relationship: RO:0002202 CL:0002633 ! develops from respiratory basal cell relationship: RO:0015004 CLM:1000059 ! has characterizing marker set NS forest marker set of respiratory tract suprabasal cell (Human lung). property_value: RO:0002175 NCBITaxon:9606 property_value: terms:contributor https://orcid.org/0000-0001-6677-8489 property_value: terms:contributor https://orcid.org/0000-0002-9185-3994 property_value: terms:date "2023-06-20T10:44:30Z" xsd:dateTime [Term] id: CL:4033049 name: taste receptor cell of tongue def: "A taste receptor cell that is part of a taste bud of a tongue." [DOI:10.1111/j.1096-3642.1981.tb01137.x, http://www.nejohnston.org/Birds/documents/AvianTongues_Johnston.pdf, PMID:10052456, PMID:28655883] subset: human_subset subset: mouse_subset synonym: "gustatory cell of tongue" RELATED [DOI:10.1016/s0022-5320(69)80043-2] is_a: CL:0000209 ! taste receptor cell is_a: CL:0002319 ! neural cell intersection_of: CL:0000209 ! taste receptor cell intersection_of: BFO:0000050 UBERON:0014451 ! part of tongue taste bud relationship: BFO:0000050 UBERON:0014451 ! part of tongue taste bud property_value: terms:contributor https://orcid.org/0000-0001-6677-8489 property_value: terms:date "2023-05-03T07:59:58Z" xsd:dateTime [Term] id: CL:4033050 name: catecholaminergic neuron def: "A neuron that releases catecholamine as a neurotransmitter." [ISBN:0521442516, PMID:12094209] comment: Frequently used when describing the developing nervous system in zebrafish. A catecholaminergic neuron expresses tyrosine hydroxylase (TH), tyrosine hydroxylase 2 (TH2), aromatic amino acid decarboxylase (AADC), dopamine b-hydroxylase (DBH), and phenylethanolamine-N-methyl transferase (PEMT), which are enzymes necessary for catecholamine synthesis. {xref="https://orcid.org/0000-0002-2244-7917", xref="PMID:12128258", xref="PMID:10191060", xref="PMID:34880760"} subset: human_reference_atlas subset: human_subset subset: mouse_subset is_a: CL:0000151 ! secretory cell is_a: CL:0000540 ! neuron intersection_of: CL:0000540 ! neuron intersection_of: RO:0002215 GO:0160043 ! capable of catecholamine secretion, neurotransmission relationship: RO:0002215 GO:0160043 ! capable of catecholamine secretion, neurotransmission property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "catecholaminergic neuron" xsd:string property_value: terms:contributor https://orcid.org/0000-0001-6677-8489 property_value: terms:date "2023-05-18T12:07:45Z" xsd:dateTime [Term] id: CL:4033051 name: OFF parasol ganglion cell def: "A parasol ganglion cell that depolarizes in response to decreased light intensity in the center of its receptive field. The majority of input that this cell receives comes from DB3a bipolar cells." [PMID:32032773] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "OFF-parasol retinal ganglion cell" EXACT [PMID:34093409] synonym: "OFF-parasol RGC" EXACT [PMID:34093409] synonym: "outer parasol cell" EXACT [PMID:32032773] is_a: CL:4023033 ! OFF retinal ganglion cell is_a: CL:4023189 ! parasol ganglion cell of retina intersection_of: CL:4023033 ! OFF retinal ganglion cell intersection_of: CL:4023189 ! parasol ganglion cell of retina property_value: terms:contributor https://orcid.org/0000-0001-6677-8489 property_value: terms:date "2023-08-08T12:34:57Z" xsd:dateTime [Term] id: CL:4033052 name: ON parasol ganglion cell def: "A parasol ganglion cell that depolarizes in response to increased light intensity in the center of its receptive field. The majority of input that this cell receives comes from DB4 bipolar cells." [PMID:32032773] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "inner parasol cell" EXACT [PMID:32032773] synonym: "ON-parasol retinal ganglion cell" EXACT [PMID:34093409] synonym: "ON-parasol RGC" EXACT [PMID:34093409] is_a: CL:4023032 ! ON retinal ganglion cell is_a: CL:4023189 ! parasol ganglion cell of retina intersection_of: CL:4023032 ! ON retinal ganglion cell intersection_of: CL:4023189 ! parasol ganglion cell of retina property_value: terms:contributor https://orcid.org/0000-0001-6677-8489 property_value: terms:date "2023-08-08T12:39:35Z" xsd:dateTime [Term] id: CL:4033053 name: small bistratified retinal ganglion cell def: "A bistratfied retinal ganglion cell with a small dendritic field that has dendrites in the ON and OFF sublamina of the retinal inner plexiform layer and carries blue-ON/yellow-OFF signals. This cell receives bipolar and amacrine input to both the OFF and ON dendritic tree." [PMID:32032773] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "Polyak's shrub cell" RELATED [PMID:32032773] synonym: "sbRGC" RELATED OMO:0003000 [PMID:34093409] synonym: "SBS ganglion cell" RELATED OMO:0003000 [PMID:32032773] synonym: "small bistratified cell" EXACT [PMID:32032773] synonym: "small bistratified cell, blue-ON/yellow-OFF ganglion cell" EXACT [doi:10.1002/cne.22183] is_a: CL:0003001 ! bistratified retinal ganglion cell relationship: RO:0002100 UBERON:0001792 ! has soma location ganglionic layer of retina property_value: terms:contributor https://orcid.org/0000-0001-6677-8489 property_value: terms:date "2023-08-08T12:43:56Z" xsd:dateTime [Term] id: CL:4033054 name: perivascular cell def: "A cell that is adjacent to a vessel. A perivascular cell plays a crucial role in maintaining vascular function and tissue homeostasis. This cell type regulates vessel integrity and flow dynamics." [PMID:24928499, PMID:27889329] subset: cellxgene_subset subset: human_subset subset: mouse_subset is_a: CL:0000000 ! cell intersection_of: CL:0000000 ! cell intersection_of: RO:0002220 UBERON:0002049 ! adjacent to vasculature relationship: RO:0002220 UBERON:0002049 ! adjacent to vasculature property_value: terms:contributor https://orcid.org/0000-0001-6677-8489 property_value: terms:date "2023-08-22T13:40:28Z" xsd:dateTime [Term] id: CL:4033055 name: airway submucosal gland duct multiciliated cell def: "A multi-ciliated epithelial cell located in ciliated duct of an airway submucosal gland, characterized by a columnar shape and motile cilia on its apical surface." [PMID:17707699, PMID:30864819] subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "airway submucosal gland duct ciliated cell" EXACT [] is_a: CL:0000068 ! duct epithelial cell is_a: CL:0005012 ! multiciliated epithelial cell intersection_of: CL:0000075 ! columnar/cuboidal epithelial cell intersection_of: BFO:0000050 UBERON:8410077 ! part of airway submucosal gland intersection_of: BFO:0000050 UBERON:8600014 ! part of submucosal gland ciliated duct intersection_of: BFO:0000051 GO:0031514 ! has part motile cilium intersection_of: RO:0000053 PATO:0010007 ! has characteristic multiciliated relationship: BFO:0000050 UBERON:8410077 ! part of airway submucosal gland relationship: BFO:0000050 UBERON:8600014 ! part of submucosal gland ciliated duct property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/2d-ftu/lung-bronchial-submucosal-gland/v1.2/assets/2d-ftu-lung-bronchial-submucosal-gland.png" xsd:string {terms:licence="http://creativecommons.org/licenses/by/4.0/", xref="doi:10.48539/HBM656.TJVD.294"} property_value: RO:0002175 NCBITaxon:9606 property_value: terms:contributor https://orcid.org/0000-0001-6677-8489 property_value: terms:contributor https://orcid.org/0000-0002-9185-3994 property_value: terms:date "2023-09-08T10:32:27Z" xsd:dateTime [Term] id: CL:4033056 name: onychocyte def: "A terminally differentiated, specialized keratinocyte originating primarily from the nail matrix. During onychokeratinization, these cells undergo progressive flattening and produce high levels of hard, disulfide cross-linked keratins (Eckhart et al., 2024) that form the rigid, compact nail plate. Unlike epidermal keratinocytes, onychocytes are firmly integrated into the nail plate and do not desquamate." [PMID:24079581, PMID:28098391, PMID:30969555, PMID:34099859, PMID:39451193] subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset is_a: CL:4052061 ! epidermal keratinocyte relationship: BFO:0000050 UBERON:0008198 ! part of nail plate property_value: RO:0002175 NCBITaxon:9606 property_value: terms:contributor https://orcid.org/0000-0001-6677-8489 property_value: terms:date "2023-10-03T12:49:46Z" xsd:dateTime [Term] id: CL:4033057 name: luminal adaptive secretory precursor cell of mammary gland def: "A luminal epithelial cell of the mammary gland that can proliferate and has the potential to differentiate into a lactocyte during pregnancy. In humans, a luminal adaptive secretory precursor cell can be identified by high levels of the markers EpCAM and CD49f, and in mice it can be identified by low levels of CD29 and high levels of CD14, Kit, CD61, and Tspan8." [https://nrs.harvard.edu/URN-3\:HUL.INSTREPOS\:37368328, https://orcid.org/0000-0001-6677-8489, PMID:19648928, PMID:35617956] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "alveolar cell" BROAD [PMID:35617956] synonym: "alveolar progenitor" BROAD [PMID:26390871] synonym: "AP" RELATED OMO:0003000 [https://nrs.harvard.edu/URN-3\:HUL.INSTREPOS\:37368328] synonym: "AV" RELATED OMO:0003000 [PMID:35617956] synonym: "ER-negative luminal alveolar progenitor" EXACT [https://nrs.harvard.edu/URN-3\:HUL.INSTREPOS\:37368328] synonym: "LASP" RELATED OMO:0003000 [https://orcid.org/0000-0001-6677-8489] synonym: "LP" RELATED OMO:0003000 [doi:10.1101/2023.04.21.537845] synonym: "luminal progenitor" BROAD [doi:10.1101/2023.04.21.537845] synonym: "luminal progenitor cell" BROAD [PMID:20346151] synonym: "luminal secretory cell" BROAD [PMID:37380767] synonym: "LumSec" RELATED OMO:0003000 [PMID:37380767] is_a: CL:0002326 ! luminal epithelial cell of mammary gland is_a: CL:0011026 ! progenitor cell property_value: terms:contributor https://orcid.org/0000-0001-6677-8489 property_value: terms:contributor https://orcid.org/0000-0003-4969-670X property_value: terms:date "2023-10-13T13:02:55Z" xsd:dateTime [Term] id: CL:4033058 name: luminal hormone-sensing cell of mammary gland def: "A luminal epithelial cell of the mammary gland that transduces endocrine cues to orchestrate proliferation, architectural remodeling, and differentiation of other cells in the mammary gland via paracrine signaling. This cell expresses high levels of estrogen receptors. In humans, a luminal hormone-sensing cell can be identified by high levels of EpCAM and low levels of CD49f, and in mice it can be identified by low levels of CD29 and high levels of Foxa1, CD133, and Sca1 (Ly6a)." [https://nrs.harvard.edu/URN-3\:HUL.INSTREPOS\:37368328, https://orcid.org/0000-0001-6677-8489, PMID:19648928, PMID:26390871, PMID:34156490] comment: Following lineage specification, a luminal hormone-sensing cell expresses receptors for one or more hormones, such as estrogens, progesterone, androgens, and prolactin. In response to progesterone, luminal hormone-sensing cells express TNFSF11, WNT4, and RSPO1, among other factors, which cause branching, proliferation, and partial differentiation in LASP and B-Myo cells during luteal phases of the estrous/menstrual cycle and during gestation. During ductal elongation, ER activity drives expression of AREG in LHS cells, which is necessary for proliferation of the epithelium to fill the mammary fat pad. {xref="PMID:34156490", xref="PMID:26390871", xref="https://orcid.org/0000-0003-4969-670X"} subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "ER-positive luminal hormone-sensor cell" EXACT [https://nrs.harvard.edu/URN-3\:HUL.INSTREPOS\:37368328] synonym: "hormone sensing cell" BROAD [doi:10.1101/2023.04.21.537845] synonym: "hormone-sensing mammary epithelial cell" BROAD [PMID:26390871] synonym: "HS" RELATED OMO:0003000 [doi:10.1101/2023.04.21.537845] synonym: "HS-MEC" RELATED OMO:0003000 [PMID:26390871] synonym: "LHS" RELATED OMO:0003000 [https://orcid.org/0000-0001-6677-8489] synonym: "LumHR" RELATED OMO:0003000 [PMID:37380767] synonym: "luminal hormone-responsive cell" BROAD [PMID:37380767] synonym: "luminal mature cell" BROAD [PMID:20346151] is_a: CL:0002326 ! luminal epithelial cell of mammary gland relationship: RO:0002104 PR:000007204 ! has plasma membrane part estrogen receptor property_value: terms:contributor https://orcid.org/0000-0001-6677-8489 property_value: terms:contributor https://orcid.org/0000-0003-4969-670X property_value: terms:date "2023-10-16T08:30:25Z" xsd:dateTime [Term] id: CL:4033059 name: lactocyte type 1 def: "A lactocyte that highly expresses genes associated with transcription, immune cell function, and cellular stress. A lactocyte type 1 also expresses genes involved in milk component biosynthesis (e.g., LALBA and CSNs), albeit at lower levels than a lactocyte type 2." [PMID:35091553, PMID:35377806] subset: human_subset subset: mouse_subset synonym: "LC1" RELATED OMO:0003000 [PMID:35091553] synonym: "LMC major luminal cluster 1" RELATED [PMID:35091553] synonym: "luminal cluster 1 cell" BROAD [PMID:34097179] synonym: "progenitor MEC" RELATED OMO:0003000 [PMID:35091553] is_a: CL:0002325 ! lactocyte property_value: terms:contributor https://orcid.org/0000-0001-6677-8489 property_value: terms:contributor https://orcid.org/0000-0003-4361-817X property_value: terms:date "2023-10-16T13:15:36Z" xsd:dateTime [Term] id: CL:4033060 name: lactocyte type 2 def: "A lactocyte that highly expresses genes associated with lipid production and milk component biosynthesis." [PMID:35091553, PMID:35377806] subset: human_subset subset: mouse_subset synonym: "LC2" RELATED OMO:0003000 [PMID:35091553] synonym: "LMC major luminal cluster 2" RELATED [PMID:35091553] synonym: "luminal cluster 2 cell" BROAD [PMID:35377806] is_a: CL:0002325 ! lactocyte property_value: terms:contributor https://orcid.org/0000-0001-6677-8489 property_value: terms:contributor https://orcid.org/0000-0003-4361-817X property_value: terms:date "2023-10-16T13:15:55Z" xsd:dateTime [Term] id: CL:4033061 name: endothelial cell of central vein of liver def: "An endothelial cell that is part of a central vein of liver." [PMID:28287163] subset: human_subset subset: mouse_subset synonym: "endothelial cell of central vein" BROAD [PMID:28287163] is_a: CL:0002543 ! vein endothelial cell intersection_of: CL:0000115 ! endothelial cell intersection_of: BFO:0000050 UBERON:0006841 ! part of central vein of liver relationship: BFO:0000050 UBERON:0006841 ! part of central vein of liver property_value: terms:contributor https://orcid.org/0000-0001-6677-8489 [Term] id: CL:4033062 name: interstitial extravillous trophoblast cell def: "A trophoblast cell that invades the uterine wall to anchor the placenta to the uterus. An interstitial extravillous trophoblast cell differentiates from an extravillous trophoblast cell, becoming hyperchromatic and changing its morphology to a fibroblast-like spindle-shaped cell. In humans, this cell can be distinguished by the expression of placental-specific protein 8, which stimulates migration." [doi:10.1007/978-3-030-84725-8, PMID:37630754] subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "iEVT" RELATED OMO:0003000 [PMID:37630754] synonym: "interstitial extravillous trophoblast" RELATED [PMID:37630754] synonym: "interstitial trophoblast" RELATED [PMID:11337369] synonym: "invasive interstitial extravillous trophoblast cell" EXACT [doi:10.1007/978-3-030-84725-8] is_a: CL:0000351 ! trophoblast cell relationship: RO:0002202 CL:0008036 ! develops from extravillous trophoblast property_value: RO:0002175 NCBITaxon:9606 property_value: terms:contributor https://orcid.org/0000-0001-6677-8489 property_value: terms:date "2024-01-08T15:43:15Z" xsd:dateTime [Term] id: CL:4033063 name: endovascular extravillous trophoblast cell def: "A trophoblast cell that invades the maternal spiral arteries and replace the endothelial lining, remodeling the vessels and allowing for adequate blood transport into the placenta. An endovascular extravillous trophoblast cell differentiates from an extravillous trophoblast cell. In humans, this cell can be distinguished by the expression of CD56." [doi:10.1007/978-3-030-84725-8, PMID:37630754] comment: Shortly after implantation, the endovascular extravillous trophoblast cells occlude the maternal spiral arteries, preventing premature oxygen delivery to the placental villi and reducing fetal oxidative stress. {xref="PMID:37630754"} subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "eEVT" RELATED OMO:0003000 [PMID:37630754] synonym: "endovascular extravillous trophoblast" RELATED [PMID:37630754] synonym: "endovascular trophoblast" RELATED [PMID:11337369] is_a: CL:0000351 ! trophoblast cell relationship: RO:0002202 CL:0008036 ! develops from extravillous trophoblast property_value: RO:0002175 NCBITaxon:9606 property_value: terms:contributor https://orcid.org/0000-0001-6677-8489 property_value: terms:date "2024-01-08T15:43:32Z" xsd:dateTime [Term] id: CL:4033064 name: uterine resident macrophage def: "A tissue-resident macrophage that is part of the uterus." [PMID:36113384] comment: Uterine macrophages are reported to be evenly distributed throughout the endometrial stroma but with aggregations observed close to the lumen of superficial secretory glands. {xref="PMID:36113384"} subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "uterine macrophage" BROAD [PMID:36113384] is_a: CL:0000864 ! tissue-resident macrophage intersection_of: CL:0000864 ! tissue-resident macrophage intersection_of: BFO:0000050 UBERON:0000995 ! part of uterus relationship: BFO:0000050 UBERON:0000995 ! part of uterus property_value: RO:0002175 NCBITaxon:9606 property_value: terms:contributor https://orcid.org/0000-0001-6677-8489 property_value: terms:date "2024-01-08T16:05:09Z" xsd:dateTime [Term] id: CL:4033065 name: preplasmablast def: "A mature B cell that serves as an intermediate stage in the differentiation of naive B cells into a plasmablast. A preplasmablast expresses CD30 and IL-6R and lacks expression of CD20, CD23, CD38 and CD138." [PMID:21918187, PMID:30755708, PMID:33150420] subset: human_subset subset: mouse_subset synonym: "pre-plasmablast" EXACT [PMID:23613519] synonym: "prePB" RELATED OMO:0003000 [PMID:21918187] synonym: "preplasmablastic cell" EXACT [PMID:33661294] is_a: CL:0000785 ! mature B cell relationship: RO:0002202 CL:0000788 ! develops from naive B cell relationship: RO:0002203 CL:0000980 ! develops into plasmablast property_value: terms:contributor https://orcid.org/0000-0001-6677-8489 property_value: terms:contributor https://orcid.org/0000-0001-7655-4833 property_value: terms:date "2024-04-25T09:14:58Z" xsd:dateTime [Term] id: CL:4033066 name: pre-granulosa cell def: "A supporting cell that is part of the ovary and differentiates into a granulosa cell. A pre-granulosa cell develops from an early supporting gonadal cell by repressing testis determination, which can then proliferate to form primordial follicles." [PMID:17639032, PMID:32759216, PMID:33970370, PMID:38178246] subset: human_subset subset: mouse_subset synonym: "ovarian pregranulosa cell" EXACT [PMID:32759216] synonym: "PG cell" RELATED OMO:0003000 [PMID:32759216] synonym: "pregranulosa cell" EXACT [PMID:17639032, PMID:32759216] is_a: CL:0000255 ! eukaryotic cell is_a: CL:0000630 ! supporting cell relationship: BFO:0000050 UBERON:0000992 ! part of ovary relationship: RO:0002210 CL:4033083 ! directly develops into squamous granulosa cell property_value: terms:contributor https://orcid.org/0000-0001-6677-8489 property_value: terms:contributor https://orcid.org/0000-0001-7655-4833 property_value: terms:date "2024-06-07T12:04:57Z" xsd:dateTime [Term] id: CL:4033067 name: mural granulosa cell def: "A follicular cell of ovary that differentiates from a cuboidal granulosa cell during the secondary follicle stage. Mural granulosa cells line the inner surface of the follicle wall, surrounding the fluid-filled antral cavity. These cells produce oestrogen during the follicular phase in response to follicle-stimulating hormone (FSH), and progesterone after ovulation in response to luteinizing hormone (LH)." [PMID:27815559, PMID:33970370, PMID:34198768] subset: human_subset subset: mouse_subset synonym: "MGC" RELATED OMO:0003000 [doi:10.1530/REP-16-0500] synonym: "mural GC" RELATED OMO:0003000 [PMID:34198768] xref: EFO:0005289 is_a: CL:0000501 ! granulosa cell is_a: UBERON:0004120 ! mesoderm-derived structure relationship: RO:0002202 CL:4033084 ! develops from cuboidal granulosa cell property_value: terms:contributor https://orcid.org/0000-0001-6677-8489 property_value: terms:contributor https://orcid.org/0000-0001-7655-4833 property_value: terms:date "2024-06-07T12:15:13Z" xsd:dateTime [Term] id: CL:4033068 name: cycling B cell def: "A(n) B cell that is cycling." [PMID:31348891] subset: human_subset subset: mouse_subset synonym: "proliferating B cell" EXACT [PMID:31348891] is_a: CL:0000236 ! B cell intersection_of: CL:0000236 ! B cell intersection_of: RO:0000056 GO:0022402 ! participates in cell cycle process intersection_of: RO:0000086 PATO:0002354 ! has quality active relationship: RO:0000056 GO:0022402 ! participates in cell cycle process relationship: RO:0000086 PATO:0002354 ! has quality active [Term] id: CL:4033069 name: cycling T cell def: "A(n) T cell that is cycling." [PMID:37291214] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "proliferating T cell" EXACT [PMID:37291214] is_a: CL:0000084 ! T cell intersection_of: CL:0000084 ! T cell intersection_of: RO:0000056 GO:0022402 ! participates in cell cycle process intersection_of: RO:0000086 PATO:0002354 ! has quality active relationship: RO:0000056 GO:0022402 ! participates in cell cycle process relationship: RO:0000086 PATO:0002354 ! has quality active [Term] id: CL:4033070 name: cycling dendritic cell def: "A(n) dendritic cell that is cycling." [PMID:32066951] subset: human_subset subset: mouse_subset synonym: "proliferating dendritic cell" EXACT [PMID:32066951] is_a: CL:0000451 ! dendritic cell is_a: CL:4033078 ! cycling mononuclear phagocyte intersection_of: CL:0000451 ! dendritic cell intersection_of: RO:0000056 GO:0022402 ! participates in cell cycle process intersection_of: RO:0000086 PATO:0002354 ! has quality active [Term] id: CL:4033071 name: cycling natural killer cell def: "A(n) natural killer cell that is cycling." [PMID:34062119] subset: human_subset subset: mouse_subset synonym: "proliferating natural killer cell" EXACT [PMID:34062119] is_a: CL:0000623 ! natural killer cell intersection_of: CL:0000623 ! natural killer cell intersection_of: RO:0000056 GO:0022402 ! participates in cell cycle process intersection_of: RO:0000086 PATO:0002354 ! has quality active relationship: RO:0000056 GO:0022402 ! participates in cell cycle process relationship: RO:0000086 PATO:0002354 ! has quality active [Term] id: CL:4033072 name: cycling gamma-delta T cell def: "A(n) gamma-delta T cell that is cycling." [PMID:32066951] subset: human_subset subset: mouse_subset synonym: "proliferating gamma-delta T cell" EXACT [PMID:32066951] is_a: CL:0000798 ! gamma-delta T cell is_a: CL:4033069 ! cycling T cell intersection_of: CL:0000798 ! gamma-delta T cell intersection_of: RO:0000056 GO:0022402 ! participates in cell cycle process intersection_of: RO:0000086 PATO:0002354 ! has quality active [Term] id: CL:4033073 name: cycling monocyte def: "A(n) monocyte that is cycling." [PMID:31348891] subset: human_subset subset: mouse_subset synonym: "proliferating monocyte" EXACT [PMID:31348891] is_a: CL:0000576 ! monocyte is_a: CL:4033078 ! cycling mononuclear phagocyte is_a: CL:4033081 ! cycling myeloid cell intersection_of: CL:0000576 ! monocyte intersection_of: RO:0000056 GO:0022402 ! participates in cell cycle process intersection_of: RO:0000086 PATO:0002354 ! has quality active [Term] id: CL:4033074 name: cycling CD8-positive, alpha-beta T cell def: "A(n) CD8-positive, alpha-beta T cell that is cycling." [PMID:34062119] subset: human_subset subset: mouse_subset synonym: "proliferating CD8-positive, alpha-beta T cell" EXACT [PMID:34062119] is_a: CL:0000625 ! CD8-positive, alpha-beta T cell is_a: CL:4033069 ! cycling T cell intersection_of: CL:0000625 ! CD8-positive, alpha-beta T cell intersection_of: RO:0000056 GO:0022402 ! participates in cell cycle process intersection_of: RO:0000086 PATO:0002354 ! has quality active [Term] id: CL:4033075 name: cycling CD4-positive, alpha-beta T cell def: "A(n) CD4-positive, alpha-beta T cell that is cycling." [PMID:34062119] subset: human_subset subset: mouse_subset synonym: "proliferating CD4-positive, alpha-beta T cell" EXACT [PMID:34062119] is_a: CL:0000624 ! CD4-positive, alpha-beta T cell is_a: CL:4033069 ! cycling T cell intersection_of: CL:0000624 ! CD4-positive, alpha-beta T cell intersection_of: RO:0000056 GO:0022402 ! participates in cell cycle process intersection_of: RO:0000086 PATO:0002354 ! has quality active [Term] id: CL:4033076 name: cycling macrophage def: "A(n) macrophage that is cycling." [PMID:33208946] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "proliferating macrophage" EXACT [PMID:33208946] is_a: CL:0000235 ! macrophage is_a: CL:4033078 ! cycling mononuclear phagocyte is_a: CL:4033081 ! cycling myeloid cell intersection_of: CL:0000235 ! macrophage intersection_of: RO:0000056 GO:0022402 ! participates in cell cycle process intersection_of: RO:0000086 PATO:0002354 ! has quality active [Term] id: CL:4033077 name: cycling alveolar macrophage def: "A(n) alveolar macrophage that is cycling." [PMID:37291214] comment: The marker set PCLAF, RRM2, UBE2C, NUSAP1 can identify the Human cell type cycling alveolar macrophage in the lung with a confidence of 0.26 (NS-Forest FBeta value). {xref="https://doi.org/10.5281/zenodo.11165918"} subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "proliferating alveolar macrophage" EXACT [PMID:37291214] is_a: CL:0000583 ! alveolar macrophage is_a: CL:4033076 ! cycling macrophage intersection_of: CL:0000583 ! alveolar macrophage intersection_of: RO:0000056 GO:0022402 ! participates in cell cycle process intersection_of: RO:0000086 PATO:0002354 ! has quality active relationship: RO:0015004 CLM:1000006 ! has characterizing marker set NS forest marker set of cycling alveolar macrophage (Human lung). property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:4033078 name: cycling mononuclear phagocyte def: "A(n) mononuclear phagocyte that is cycling." [PMID:37468583] subset: human_subset subset: mouse_subset synonym: "proliferating mononuclear phagocyte" EXACT [PMID:37468583] is_a: CL:0000113 ! mononuclear phagocyte intersection_of: CL:0000113 ! mononuclear phagocyte intersection_of: RO:0000056 GO:0022402 ! participates in cell cycle process intersection_of: RO:0000086 PATO:0002354 ! has quality active relationship: RO:0000056 GO:0022402 ! participates in cell cycle process relationship: RO:0000086 PATO:0002354 ! has quality active [Term] id: CL:4033079 name: cycling endothelial cell of lymphatic vessel def: "A(n) endothelial cell of lymphatic vessel that is cycling." [PMID:37291214] subset: human_subset subset: mouse_subset synonym: "proliferating endothelial cell of lymphatic vessel" EXACT [PMID:37291214] is_a: CL:0002138 ! endothelial cell of lymphatic vessel intersection_of: CL:0002138 ! endothelial cell of lymphatic vessel intersection_of: RO:0000056 GO:0022402 ! participates in cell cycle process intersection_of: RO:0000086 PATO:0002354 ! has quality active relationship: RO:0000056 GO:0022402 ! participates in cell cycle process relationship: RO:0000086 PATO:0002354 ! has quality active [Term] id: CL:4033080 name: cycling pulmonary alveolar type 2 cell def: "A(n) pulmonary alveolar type 2 cell that is cycling." [PMID:37291214] comment: The marker set PEG10, PRC1, TOP2A can identify the Human cell type cycling pulmonary alveolar type 2 cell in the lung with a confidence of 0.61 (NS-Forest FBeta value). {xref="https://doi.org/10.5281/zenodo.11165918"} subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "proliferating pulmonary alveolar type 2 cell" EXACT [PMID:37291214] is_a: CL:0002063 ! pulmonary alveolar type 2 cell intersection_of: CL:0002063 ! pulmonary alveolar type 2 cell intersection_of: RO:0000056 GO:0022402 ! participates in cell cycle process intersection_of: RO:0000086 PATO:0002354 ! has quality active relationship: RO:0000056 GO:0022402 ! participates in cell cycle process relationship: RO:0000086 PATO:0002354 ! has quality active relationship: RO:0015004 CLM:1000010 ! has characterizing marker set NS forest marker set of cycling pulmonary alveolar type 2 cell (Human lung). property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:4033081 name: cycling myeloid cell def: "A(n) myeloid cell that is cycling." [PMID:38301653] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "proliferating myeloid cell" EXACT [PMID:38301653] is_a: CL:0000763 ! myeloid cell intersection_of: CL:0000763 ! myeloid cell intersection_of: RO:0000056 GO:0022402 ! participates in cell cycle process intersection_of: RO:0000086 PATO:0002354 ! has quality active relationship: RO:0000056 GO:0022402 ! participates in cell cycle process relationship: RO:0000086 PATO:0002354 ! has quality active [Term] id: CL:4033082 name: cycling basal cell def: "A(n) basal cell that is cycling." [PMID:33208946] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "proliferating basal cell" EXACT [PMID:33208946] is_a: BFO:0000002 is_a: CL:0000646 ! basal cell intersection_of: CL:0000646 ! basal cell intersection_of: RO:0000056 GO:0022402 ! participates in cell cycle process intersection_of: RO:0000086 PATO:0002354 ! has quality active relationship: RO:0000056 GO:0022402 ! participates in cell cycle process relationship: RO:0000086 PATO:0002354 ! has quality active [Term] id: CL:4033083 name: squamous granulosa cell def: "A granulosa cell that has a squamous morphology and form a single layer around the oocyte in primordial follicles. This cell develops directly into a cuboidal granulosa cell during the primordial-to-primary follicle transition." [PMID:28892263] comment: Often in literature squamous granulosa cell and pre-granulosa cell are used as synonyms. However, this term only makes reference to the quiescent granulosa cells that surround the primordial ovarian follicle, while a pre-granulosa cell proliferates to form the primordial follicle (and thus cells become the squamous granulosa cells). {xref="https://orcid.org/0000-0001-6677-8489"} subset: human_subset subset: mouse_subset synonym: "flattened granulosa cell" EXACT [PMID:22402964] synonym: "pre-granulosa cell" RELATED [PMID:33914868] synonym: "squamous GC" RELATED OMO:0003000 [PMID:33914868] is_a: CL:0000501 ! granulosa cell relationship: BFO:0000050 UBERON:0003981 ! part of primordial ovarian follicle relationship: RO:0002207 CL:4033066 ! directly develops from pre-granulosa cell relationship: RO:0002210 CL:4033084 ! directly develops into cuboidal granulosa cell property_value: terms:contributor https://orcid.org/0000-0001-6677-8489 property_value: terms:date "2024-09-24T13:13:24Z" xsd:dateTime [Term] id: CL:4033084 name: cuboidal granulosa cell def: "A granulosa cell that has a cuboidal morphology and develops from squamous granulosa cell during the transition between primordial follicle to primary follicle. Cuboidal granulosa cells proliferate to form a second layer within secondary follicles." [PMID:28892263] subset: human_subset subset: mouse_subset synonym: "columnar GC" RELATED OMO:0003000 [PMID:19001500] synonym: "columnar granulosa cell" EXACT [PMID:19001500] synonym: "cuboidal epithelial granulosa cell" EXACT [PMID:31849844] synonym: "cuboidal GC" RELATED OMO:0003000 [PMID:33914868] is_a: CL:0000501 ! granulosa cell is_a: UBERON:0004120 ! mesoderm-derived structure relationship: RO:0002207 CL:4033083 ! directly develops from squamous granulosa cell property_value: terms:contributor https://orcid.org/0000-0001-6677-8489 property_value: terms:date "2024-09-24T13:14:57Z" xsd:dateTime [Term] id: CL:4033085 name: diffuse bipolar 5 cell def: "An ON diffuse bipolar cell that stratifies in the stratum 3 of the inner plexiform layer to make synapses with ON parasol ganglion cells. A diffuse bipolar 5 cell has high expression of MYO16 compared with other bipolar cells." [PMID:27833534, PMID:32032773] comment: A diffuse bipolar 5 cell typically contacts 7–8 cone photoreceptors. The number and thickness of its dendritic processes are intermediate between those of a diffuse bipolar 6 cell (less dense and thinner) and a diffuse bipolar 4 cell (denser and thicker). {xref="PMID:27833534"} subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "DB5 cell" RELATED OMO:0003000 [PMID:32032773] is_a: CL:0000749 ! ON-bipolar cell property_value: RO:0002175 NCBITaxon:9443 property_value: terms:contributor https://orcid.org/0000-0001-6677-8489 property_value: terms:date "2024-10-16T12:46:53Z" xsd:dateTime [Term] id: CL:4033086 name: lipid-associated macrophage def: "A tissue-resident macrophage that is associated with lipids. This cell responsible of anti-inflammatory functions, lipid accumulation and enhancing phagocytosis (Wculek et al., 2022, Liu et al., 2022). In mice and humans, a lipid-associated macrophage is characterized by the marker Trem2 (Jaitlin et al., 2019)." [PMID:31257031, PMID:34876704, PMID:35712121] comment: Distinct from “adipose macrophage” in Trem2 expression, and is not limited to adipose tissue. Guilliams et al. describe these cells as being distinct from Kupffer cells. {xref="PMID:37153549", xref="PMID:35021063"} subset: human_subset subset: mouse_subset synonym: "LAM" RELATED OMO:0003000 [PMID:31257031] is_a: CL:4047053 ! TREM2-positive macrophage property_value: terms:contributor https://orcid.org/0000-0001-6677-8489 property_value: terms:contributor https://orcid.org/0000-0001-8134-3037 property_value: terms:date "2024-10-17T10:20:13Z" xsd:dateTime [Term] id: CL:4033087 name: placental resident macrophage def: "A tissue-resident macrophage that is part of the placenta. This cell helps preventing immunological rejection of the fetus by modulating the immune environment. A placental resident macrophage has high plasticity to adapt to the changing needs of each phase of pregnancy." [PMID:39007150] subset: human_subset subset: mouse_subset synonym: "placental macrophage" BROAD [PMID:39007150] is_a: CL:0000864 ! tissue-resident macrophage intersection_of: CL:0000864 ! tissue-resident macrophage intersection_of: BFO:0000050 UBERON:0001987 ! part of placenta relationship: BFO:0000050 UBERON:0001987 ! part of placenta property_value: terms:contributor https://orcid.org/0000-0001-6677-8489 property_value: terms:contributor https://orcid.org/0000-0001-7655-4833 property_value: terms:date "2024-10-31T10:24:21Z" xsd:dateTime [Term] id: CL:4033088 name: decidual resident macrophage def: "A resident macrophage that is part of the decidua. Some decidual macrophages are derived from maternal blood monocytes that are recruited to the uterus shortly after conception. The main functions of a decidual macrophage are implantation, placental development, immune regulation and vascular remodeling." [PMID:39007150] subset: human_subset subset: mouse_subset synonym: "decidual macrophage" BROAD [PMID:39007150] synonym: "maternal decidual macrophage" BROAD [PMID:39007150] is_a: CL:0000349 ! extraembryonic cell is_a: CL:4033087 ! placental resident macrophage relationship: BFO:0000050 UBERON:0002450 ! part of decidua property_value: terms:contributor https://orcid.org/0000-0001-6677-8489 property_value: terms:contributor https://orcid.org/0000-0001-7655-4833 property_value: terms:date "2024-10-31T10:33:04Z" xsd:dateTime [Term] id: CL:4033089 name: atretic follicular cell of ovary def: "A follicular cell of ovary that has begun to degenerate and undergo atresia, a specialized apoptosis. This cell is found in an atretic follicle, which is an ovarian follicle that started to mature but failed to reach full development and instead regresses." [PMID:38069168] subset: human_subset subset: mouse_subset is_a: BFO:0000002 is_a: CL:0002174 ! follicular cell of ovary intersection_of: CL:0002174 ! follicular cell of ovary intersection_of: RO:0000056 GO:0001552 ! participates in ovarian follicle atresia relationship: RO:0000056 GO:0001552 ! participates in ovarian follicle atresia property_value: terms:contributor https://orcid.org/0000-0001-6677-8489 property_value: terms:date "2024-11-05T11:23:25Z" xsd:dateTime [Term] id: CL:4033090 name: atretic granulosa cell def: "A granulosa cell that is undergoing atresia. This cell type displays distinct morphological alterations compared with a healthy granulosa cell, including pyknosis (nuclear condensation) and cellular shrinkage." [PMID:15353131, PMID:38069168] subset: human_subset subset: mouse_subset synonym: "apoptotic granulosa cell" RELATED [PMID:15353131] is_a: CL:4033089 ! atretic follicular cell of ovary relationship: RO:0002202 CL:0000501 ! develops from granulosa cell property_value: terms:contributor https://orcid.org/0000-0001-6677-8489 property_value: terms:date "2024-11-05T11:25:28Z" xsd:dateTime [Term] id: CL:4033091 name: glycinergic-GABAergic amacrine cell def: "An amacrine cell that uses both GABA and glycine as neurotransmitters." [PMID:37124720] subset: human_subset subset: mouse_subset synonym: "glycinergic/GABAergic amacrine neuron" EXACT [PMID:37124720] is_a: CL:0008059 ! GABA-Gly neuron is_a: CL:4030027 ! GABAergic amacrine cell is_a: CL:4030028 ! glycinergic amacrine cell intersection_of: CL:0000561 ! amacrine cell intersection_of: RO:0002215 GO:0061534 ! capable of gamma-aminobutyric acid secretion, neurotransmission intersection_of: RO:0002215 GO:0061537 ! capable of glycine secretion, neurotransmission property_value: terms:contributor https://orcid.org/0000-0001-6677-8489 property_value: terms:date "2024-12-02T13:44:17Z" xsd:dateTime [Term] id: CL:4033092 name: CD57-positive enterocyte def: "An enterocyte that is part of a duodenal epithelium and expresses beta-1,3-glucuronyltransferase 1 (B3GAT1), also known as CD57 or HNK-1." [PMID:37468586] comment: While CD57 is traditionally associated with immune cells (e.g., NK cells), its expression on enterocytes marks unique epithelial subsets with specific functions or maturation states. These cells are specially enriched in areas of the duodenum within submucosal glands. {xref="PMID:37468586"} subset: human_subset subset: mouse_subset synonym: "CD57+ enterocyte" EXACT [PMID:37468586] is_a: CL:1000335 ! enterocyte of epithelium of intestinal villus intersection_of: CL:0000584 ! enterocyte intersection_of: BFO:0000050 UBERON:0008346 ! part of duodenal epithelium intersection_of: RO:0002292 PR:000001440 ! expresses galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1 relationship: BFO:0000050 UBERON:0008346 ! part of duodenal epithelium relationship: RO:0002292 PR:000001440 ! expresses galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1 property_value: terms:contributor https://orcid.org/0000-0001-6677-8489 property_value: terms:contributor https://orcid.org/0000-0001-7655-4833 property_value: terms:contributor https://orcid.org/0000-0001-9961-7673 property_value: terms:date "2024-12-06T14:32:49Z" xsd:dateTime [Term] id: CL:4033093 name: limbal epithelial stem cell of cornea def: "A stem cell that is part of the corneo-scleral limbus. This cell type resides at the basal layer of the epithelium and has a small size and high nuclear to cytoplasmatic ratio (Secker and Daniels, 2009). A limbal stem cell is responsible for corneal epithelial renewal and repair (Li et al., 2023), and to help maintain a clear corneal surface by preventing conjunctival epithelial cells from migrating onto the cornea (Wang et al., 2023)." [PMID:20614614, PMID:29105366, PMID:36983561, PMID:37768272] subset: human_subset subset: mouse_subset synonym: "LESC" RELATED OMO:0003000 [PMID:20614614] synonym: "limbal epithelial stem cell" EXACT [PMID:20614614] synonym: "limbal stem cell" EXACT [PMID:17562792] synonym: "LSC" RELATED OMO:0003000 [PMID:36983561] is_a: CL:0000036 ! epithelial fate stem cell intersection_of: CL:0000034 ! stem cell intersection_of: BFO:0000050 UBERON:0006761 ! part of corneo-scleral junction relationship: BFO:0000050 UBERON:0000482 ! part of basal lamina of epithelium relationship: BFO:0000050 UBERON:0006761 ! part of corneo-scleral junction relationship: RO:0002203 CL:0000575 ! develops into corneal epithelial cell property_value: terms:contributor https://orcid.org/0000-0001-6677-8489 property_value: terms:contributor https://orcid.org/0000-0001-7655-4833 property_value: terms:date "2024-12-11T13:59:19Z" xsd:dateTime [Term] id: CL:4033094 name: age-associated B cell def: "A transcriptionally distinct memory B cell whose presence increases with age, during infections, and in autoimmune diseases. In humans and mice, this cell type can be identified by the expression of T-bet, CD11c, CD11b, and the lack of CD21. An age-associated B cell responds to TLR stimuli, may produce autoantibodies, and participates in antiviral responses and pathogen clearance." [PMID:30873171, PMID:31986068, PMID:35298565, PMID:35798993] subset: human_subset subset: mouse_subset synonym: "ABC" RELATED OMO:0003000 [PMID:35798993] is_a: CL:0000787 ! memory B cell property_value: terms:contributor https://orcid.org/0000-0001-6677-8489 property_value: terms:contributor https://orcid.org/0000-0001-7655-4833 property_value: terms:date "2025-01-08T14:44:57Z" xsd:dateTime [Term] id: CL:4033095 name: diffuse bipolar 4a cell def: "An ON bipolar cell that has high expression of DIRC3, KCNJ3, LINC01915, PTPRK compared with other bipolar cells." [doi:10.1101/2023.11.07.566105, PMID:31995762] comment: The marker set LINC01915 can identify the Human cell type http://purl.obolibrary.org/obo/CL_4033095 in the retina with a confidence of 0.814956496 (NS-Forest FBeta value). The marker set LINC01915 can identify the Human cell type http://purl.obolibrary.org/obo/CL_4033095 in the retina with a confidence of 0.871187664 (NS-Forest FBeta value). The marker set PAM, LAMA2 can identify the Human cell type http://purl.obolibrary.org/obo/CL_4033095 in the retina with a confidence of 0.608139214 (NS-Forest FBeta value). {xref="https://doi.org/10.5281/zenodo.11165918"} subset: cellxgene_subset subset: human_subset synonym: "DB4a" RELATED OMO:0003000 [doi:10.1101/2023.11.07.566105] is_a: CL:0000749 ! ON-bipolar cell relationship: RO:0002162 NCBITaxon:9606 ! in taxon Homo sapiens relationship: RO:0015004 CLM:1001239 ! has characterizing marker set NS forest marker set of diffuse bipolar 4a cell (Human retina). relationship: RO:0015004 CLM:1001246 ! has characterizing marker set NS forest marker set of diffuse bipolar 4a cell (Human retina). relationship: RO:0015004 CLM:1001263 ! has characterizing marker set NS forest marker set of diffuse bipolar 4a cell (Human retina). property_value: RO:0002175 NCBITaxon:9606 property_value: terms:contributor https://orcid.org/0000-0001-6677-8489 property_value: terms:date "2025-01-14T13:48:42Z" xsd:dateTime [Term] id: CL:4033096 name: diffuse bipolar 4b cell def: "An ON bipolar cell that has high expression of NOS1AP compared with other bipolar cells." [doi:10.1101/2023.11.07.566105, PMID:31995762] comment: The marker set PAM, LAMA2 can identify the Human cell type http://purl.obolibrary.org/obo/CL_4033096 in the retina with a confidence of 0.489741893 (NS-Forest FBeta value). {xref="https://doi.org/10.5281/zenodo.11165918"} subset: cellxgene_subset subset: human_subset synonym: "DB4b" RELATED OMO:0003000 [doi:10.1101/2023.11.07.566105] is_a: CL:0000749 ! ON-bipolar cell relationship: RO:0002162 NCBITaxon:9606 ! in taxon Homo sapiens relationship: RO:0015004 CLM:1001256 ! has characterizing marker set NS forest marker set of diffuse bipolar 4b cell (Human retina). property_value: RO:0002175 NCBITaxon:9606 property_value: terms:contributor https://orcid.org/0000-0001-6677-8489 property_value: terms:date "2025-01-14T13:49:08Z" xsd:dateTime [Term] id: CL:4033097 name: Schlemm's canal endothelial cell def: "A specialised endothelial cell that is part of the canal of Schlemm. This cell type shares characteristics and expresses markers of both blood and lymphatic endothelial cells (Kizhatil et al., 2014) and regulates aqueous humor outflow resistance by modulating pore formation and responding to mechanical strain (Stamer et al., 2015)." [PMID:25051267, PMID:25223880] subset: human_subset subset: mouse_subset synonym: "SC endothelial cell" RELATED OMO:0003000 [PMID:25051267] synonym: "SEC" RELATED OMO:0003000 [PMID:25051267] is_a: CL:0002543 ! vein endothelial cell intersection_of: CL:0000115 ! endothelial cell intersection_of: BFO:0000050 UBERON:0004029 ! part of canal of Schlemm relationship: BFO:0000050 UBERON:0004029 ! part of canal of Schlemm property_value: foaf:depiction "http://purl.obolibrary.org/obo/cl/images/Schlemms_canal_endo_cell_PMID26402712.png" xsd:anyURI {dc:license="http://creativecommons.org/licenses/by/4.0/", xref="PMID:26402712", comment="Schematic of the conventional outflow pathway, showing the Schlemm's canal (SC, green) and the trabecular meshwork (TM, orange). The left inset shows an expanded view of the Schlemm’s canal’s microanatomy detailing the cell morphology of the inner and outer wall endocrine cells."} property_value: terms:contributor https://orcid.org/0000-0001-6677-8489 property_value: terms:date "2025-06-16T13:55:29Z" xsd:dateTime [Term] id: CL:4033098 name: inner wall Schlemm's canal endothelial cell def: "A Schlemm's canal endothelial cell that lines the inner wall of the Schlemm's canal. This cell exhibits a cobblestone appearance due to the significant biomechanical load it experiences, as well as the segmental flow of aqueous humor. The degree of biomechanical stress can lead to the formation of dome-like outpouchings known as giant vacuoles. In addition, the cell contains transcellular pores that mediate aqueous humor transport (Dautriche et al., 2015). This endothelial cell also displays prominent peripheral F-actin bands which help maintain structural integrity under pressure (Ethier et al., 2004)." [PMID:15454474, PMID:26402712] subset: human_subset subset: mouse_subset synonym: "HSCIW cell" RELATED OMO:0003000 [PMID:26402712] synonym: "human Schlemm's canal inner wall cell" NARROW [PMID:26402712] is_a: CL:4033097 ! Schlemm's canal endothelial cell relationship: BFO:0000051 GO:0046930 ! has part pore complex property_value: foaf:depiction "http://purl.obolibrary.org/obo/cl/images/Schlemms_canal_endo_cell_PMID26402712.png" xsd:anyURI {dc:license="http://creativecommons.org/licenses/by/4.0/", xref="PMID:26402712", comment="Schematic of the conventional outflow pathway, showing the Schlemm's canal (SC, green) and the trabecular meshwork (TM, orange). The left inset shows an expanded view of the Schlemm’s canal’s microanatomy detailing the cell morphology of the inner and outer wall endocrine cells. The inner wall endocrine cells, shown in blue, line the canal surface facing the trabecular meshwork. Some of the inner wall cells contain giant vacuoles."} property_value: terms:contributor https://orcid.org/0000-0001-6677-8489 property_value: terms:date "2025-06-17T13:33:32Z" xsd:dateTime [Term] id: CL:4033099 name: outer wall Schlemm's canal endothelial cell def: "A Schlemm's canal endothelial cell that lines the outer wall of the Schlemm's canal. This cell displays a smooth and flat morphology (Dautriche et al., 2015) and it is distinguished by the presence of Weibel-Palade bodies, specialized organelles that produce, store, and release P-Selectin (Hamanaka et al., 1992). This endothelial cell also exhibits stellate (star-shaped) actin arrangements distributed throughout much of the cell (Ethier et al., 2004)." [PMID:1426078, PMID:15454474, PMID:26402712] subset: human_subset subset: mouse_subset is_a: CL:4033097 ! Schlemm's canal endothelial cell relationship: BFO:0000051 GO:0033093 ! has part Weibel-Palade body relationship: BFO:0000051 PR:000001432 ! has part P-selectin property_value: foaf:depiction "http://purl.obolibrary.org/obo/cl/images/Schlemms_canal_endo_cell_PMID26402712.png" xsd:anyURI {dc:license="http://creativecommons.org/licenses/by/4.0/", xref="PMID:26402712", comment="Schematic of the conventional outflow pathway, showing the Schlemm's canal (SC, green) and the trabecular meshwork (TM, orange). The left inset shows an expanded view of the Schlemm’s canal’s microanatomy detailing the cell morphology of the inner and outer wall endocrine cells. The outer wall endocrine cells, shown in green, line the side of Schlemm’s canal facing the collector channels and venous system."} property_value: terms:contributor https://orcid.org/0000-0001-6677-8489 property_value: terms:date "2025-06-17T13:33:41Z" xsd:dateTime [Term] id: CL:4033100 name: atrial intrinsic cardiac ganglion TH neuron def: "A sympathetic neuron that has the soma located in the atrial intrinsic cardiac ganglion and expresses the marker tyrosine hydroxylase (TH)." [FBC:Autogenerated, PMID:38687681] subset: human_subset subset: mouse_subset is_a: CL:0010022 ! cardiac neuron is_a: CL:0011103 ! sympathetic neuron relationship: RO:0002100 UBERON:8600120 ! has soma location atrial intrinsic cardiac ganglion relationship: RO:0002292 PR:000016301 ! expresses tyrosine 3-monooxygenase property_value: terms:contributor https://orcid.org/0000-0001-6677-8489 property_value: terms:date "2025-07-22T09:18:18Z" xsd:dateTime [Term] id: CL:4033101 name: superior cervical ganglion TH/DBH neuron def: "A sympathetic neuron that has the soma located in the superior cervical ganglion and expresses the marker tyrosine hydroxylase (TH) and dopamine beta-hydroxylase (DBH)." [doi:10.1016/0006-8993(92)90591-V, FBC:Autogenerated] subset: human_subset subset: mouse_subset is_a: CL:0011103 ! sympathetic neuron relationship: RO:0002100 UBERON:0001989 ! has soma location superior cervical ganglion relationship: RO:0002292 PR:000006294 ! expresses dopamine beta-hydroxylase relationship: RO:0002292 PR:000016301 ! expresses tyrosine 3-monooxygenase property_value: terms:contributor https://orcid.org/0000-0001-6677-8489 property_value: terms:date "2025-07-22T09:18:18Z" xsd:dateTime [Term] id: CL:4033102 name: superior cervical ganglion TH neuron def: "A sympathetic neuron that has the soma located in the superior cervical ganglion and expresses the marker tyrosine hydroxylase (TH)." [doi:10.1016/j.tice.2019.04.006, FBC:Autogenerated] subset: human_subset subset: mouse_subset is_a: CL:0011103 ! sympathetic neuron relationship: RO:0002100 UBERON:0001989 ! has soma location superior cervical ganglion relationship: RO:0002292 PR:000016301 ! expresses tyrosine 3-monooxygenase property_value: terms:contributor https://orcid.org/0000-0001-6677-8489 property_value: terms:date "2025-07-22T09:18:18Z" xsd:dateTime [Term] id: CL:4033103 name: superior cervical ganglion NPY neuron def: "A sympathetic neuron that has the soma located in the superior cervical ganglion and expresses the marker neuropeptide Y (NPY)." [doi:10.1016/0006-8993(92)90591-V, FBC:Autogenerated] subset: human_subset subset: mouse_subset is_a: CL:0011103 ! sympathetic neuron relationship: RO:0002100 UBERON:0001989 ! has soma location superior cervical ganglion relationship: RO:0002292 PR:000011387 ! expresses neuropeptide Y property_value: terms:contributor https://orcid.org/0000-0001-6677-8489 property_value: terms:date "2025-07-22T09:18:18Z" xsd:dateTime [Term] id: CL:4033104 name: superior cervical ganglion TH/NPY neuron def: "A sympathetic neuron that has the soma located in the superior cervical ganglion and expresses the marker tyrosine hydroxylase (TH) and neuropeptide Y (NPY)." [doi:10.1016/0006-8993(92)90591-V, doi:10.1016/j.tice.2019.04.006, doi:10.1016/S0304-3940(99)00115-9, FBC:Autogenerated] subset: human_subset subset: mouse_subset is_a: CL:0011103 ! sympathetic neuron relationship: RO:0002100 UBERON:0001989 ! has soma location superior cervical ganglion relationship: RO:0002292 PR:000011387 ! expresses neuropeptide Y relationship: RO:0002292 PR:000016301 ! expresses tyrosine 3-monooxygenase property_value: terms:contributor https://orcid.org/0000-0001-6677-8489 property_value: terms:date "2025-07-22T09:18:18Z" xsd:dateTime [Term] id: CL:4033105 name: superior cervical ganglion SST neuron def: "A sympathetic neuron that has the soma located in the superior cervical ganglion and expresses the marker somatostatin (SST)." [doi:10.1016/0006-8993(92)90591-V, FBC:Autogenerated] subset: human_subset subset: mouse_subset is_a: CL:0011103 ! sympathetic neuron relationship: RO:0002100 UBERON:0001989 ! has soma location superior cervical ganglion relationship: RO:0002292 PR:000015665 ! expresses somatostatin property_value: terms:contributor https://orcid.org/0000-0001-6677-8489 property_value: terms:date "2025-07-22T09:18:18Z" xsd:dateTime [Term] id: CL:4033106 name: superior cervical ganglion VIP neuron def: "A sympathetic neuron that has the soma located in the superior cervical ganglion and expresses the marker vasoactive intestinal peptide (VIP)." [doi:10.1016/0006-8993(92)90591-V, doi:10.1016/j.tice.2019.04.006, FBC:Autogenerated] subset: human_subset subset: mouse_subset is_a: CL:0011103 ! sympathetic neuron relationship: RO:0002100 UBERON:0001989 ! has soma location superior cervical ganglion relationship: RO:0002292 PR:000017299 ! expresses VIP peptides property_value: terms:contributor https://orcid.org/0000-0001-6677-8489 property_value: terms:date "2025-07-22T09:18:18Z" xsd:dateTime [Term] id: CL:4033107 name: superior cervical ganglion CGRP neuron def: "A sympathetic neuron that has the soma located in the superior cervical ganglion and expresses the marker calcitonin gene-related peptide (CGRP)." [doi:10.1016/0006-8993(92)90591-V, FBC:Autogenerated, PMID:29154859] subset: human_subset subset: mouse_subset is_a: CL:0011103 ! sympathetic neuron relationship: RO:0002100 UBERON:0001989 ! has soma location superior cervical ganglion relationship: RO:0002292 PR:000027226 ! expresses calcitonin gene-related peptide 1 property_value: terms:contributor https://orcid.org/0000-0001-6677-8489 property_value: terms:date "2025-07-22T09:18:18Z" xsd:dateTime [Term] id: CL:4033108 name: middle cervical ganglion DBH neuron def: "A sympathetic neuron that has the soma located in the middle cervical ganglion and expresses the marker dopamine beta-hydroxylase (DBH)." [doi:10.1016/j.tice.2019.04.006, FBC:Autogenerated] subset: human_subset subset: mouse_subset is_a: CL:0011103 ! sympathetic neuron relationship: RO:0002100 UBERON:0001990 ! has soma location middle cervical ganglion relationship: RO:0002292 PR:000006294 ! expresses dopamine beta-hydroxylase property_value: terms:contributor https://orcid.org/0000-0001-6677-8489 property_value: terms:date "2025-07-22T09:18:18Z" xsd:dateTime [Term] id: CL:4033109 name: middle cervical ganglion TH neuron def: "A sympathetic neuron that has the soma located in the middle cervical ganglion and expresses the marker tyrosine hydroxylase (TH)." [doi:10.1016/j.tice.2019.04.006, FBC:Autogenerated] subset: human_subset subset: mouse_subset is_a: CL:0011103 ! sympathetic neuron relationship: RO:0002100 UBERON:0001990 ! has soma location middle cervical ganglion relationship: RO:0002292 PR:000016301 ! expresses tyrosine 3-monooxygenase property_value: terms:contributor https://orcid.org/0000-0001-6677-8489 property_value: terms:date "2025-07-22T09:18:18Z" xsd:dateTime [Term] id: CL:4033110 name: middle cervical ganglion TH/NPY neuron def: "A sympathetic neuron that has the soma located in the middle cervical ganglion and expresses the marker tyrosine hydroxylase (TH) and neuropeptide Y (NPY)." [doi:10.1016/j.tice.2019.04.006, FBC:Autogenerated] subset: human_subset subset: mouse_subset is_a: CL:0011103 ! sympathetic neuron relationship: RO:0002100 UBERON:0001990 ! has soma location middle cervical ganglion relationship: RO:0002292 PR:000011387 ! expresses neuropeptide Y relationship: RO:0002292 PR:000016301 ! expresses tyrosine 3-monooxygenase property_value: terms:contributor https://orcid.org/0000-0001-6677-8489 property_value: terms:date "2025-07-22T09:18:18Z" xsd:dateTime [Term] id: CL:4033111 name: middle cervical ganglion NPY neuron def: "A sympathetic neuron that has the soma located in the middle cervical ganglion and expresses the marker neuropeptide Y (NPY)." [doi:10.1016/j.tice.2019.04.006, FBC:Autogenerated] subset: human_subset subset: mouse_subset is_a: CL:0011103 ! sympathetic neuron relationship: RO:0002100 UBERON:0001990 ! has soma location middle cervical ganglion relationship: RO:0002292 PR:000011387 ! expresses neuropeptide Y property_value: terms:contributor https://orcid.org/0000-0001-6677-8489 property_value: terms:date "2025-07-22T09:18:18Z" xsd:dateTime [Term] id: CL:4033112 name: middle cervical ganglion VIP neuron def: "A sympathetic neuron that has the soma located in the middle cervical ganglion and expresses the marker vasoactive intestinal peptide (VIP)." [doi:10.1016/j.tice.2019.04.006, FBC:Autogenerated] subset: human_subset subset: mouse_subset is_a: CL:0011103 ! sympathetic neuron relationship: RO:0002100 UBERON:0001990 ! has soma location middle cervical ganglion relationship: RO:0002292 PR:000017299 ! expresses VIP peptides property_value: terms:contributor https://orcid.org/0000-0001-6677-8489 property_value: terms:date "2025-07-22T09:18:18Z" xsd:dateTime [Term] id: CL:4033113 name: cervicothoracic ganglion enkephalin neuron def: "A sympathetic neuron that has the soma located in the cervicothoracic ganglion and expresses the marker enkephalin." [doi:10.1016/0306-4522(81)90126-3, FBC:Autogenerated] subset: human_subset subset: mouse_subset is_a: CL:0011103 ! sympathetic neuron relationship: RO:0002100 UBERON:0002441 ! has soma location cervicothoracic ganglion relationship: RO:0002292 PR:000020924 ! expresses proenkephalin-A proteolytic cleavage product property_value: terms:contributor https://orcid.org/0000-0001-6677-8489 property_value: terms:date "2025-07-22T09:18:18Z" xsd:dateTime [Term] id: CL:4033114 name: cervicothoracic ganglion TH neuron def: "A sympathetic neuron that has the soma located in the cervicothoracic ganglion and expresses the marker tyrosine hydroxylase (TH)." [doi:10.1016/j.tice.2019.04.006, FBC:Autogenerated] subset: human_subset subset: mouse_subset is_a: CL:0011103 ! sympathetic neuron relationship: RO:0002100 UBERON:0002441 ! has soma location cervicothoracic ganglion relationship: RO:0002292 PR:000016301 ! expresses tyrosine 3-monooxygenase property_value: terms:contributor https://orcid.org/0000-0001-6677-8489 property_value: terms:date "2025-07-22T09:18:18Z" xsd:dateTime [Term] id: CL:4033115 name: cervicothoracic ganglion TH/NPY neuron def: "A sympathetic neuron that has the soma located in the cervicothoracic ganglion and expresses the marker tyrosine hydroxylase (TH) and neuropeptide Y (NPY)." [doi:10.1016/j.tice.2019.04.006, FBC:Autogenerated] subset: human_subset subset: mouse_subset is_a: CL:0011103 ! sympathetic neuron relationship: RO:0002100 UBERON:0002441 ! has soma location cervicothoracic ganglion relationship: RO:0002292 PR:000011387 ! expresses neuropeptide Y relationship: RO:0002292 PR:000016301 ! expresses tyrosine 3-monooxygenase property_value: terms:contributor https://orcid.org/0000-0001-6677-8489 property_value: terms:date "2025-07-22T09:18:18Z" xsd:dateTime [Term] id: CL:4033116 name: cervicothoracic ganglion VIP neuron def: "A sympathetic neuron that has the soma located in the cervicothoracic ganglion and expresses the marker vasoactive intestinal peptide (VIP)." [doi:10.1016/j.tice.2019.04.006, FBC:Autogenerated] subset: human_subset subset: mouse_subset is_a: CL:0011103 ! sympathetic neuron relationship: RO:0002100 UBERON:0002441 ! has soma location cervicothoracic ganglion relationship: RO:0002292 PR:000017299 ! expresses VIP peptides property_value: terms:contributor https://orcid.org/0000-0001-6677-8489 property_value: terms:date "2025-07-22T09:18:18Z" xsd:dateTime [Term] id: CL:4033117 name: cervicothoracic ganglion VAChT neuron def: "A sympathetic neuron that has the soma located in the cervicothoracic ganglion and expresses the marker vesicular acetylcholine transporter (VAChT)." [doi:10.1172/jci.insight.94715, FBC:Autogenerated] subset: human_subset subset: mouse_subset is_a: CL:0011103 ! sympathetic neuron relationship: RO:0002100 UBERON:0002441 ! has soma location cervicothoracic ganglion relationship: RO:0002292 PR:000014968 ! expresses vesicular acetylcholine transporter property_value: terms:contributor https://orcid.org/0000-0001-6677-8489 property_value: terms:date "2025-07-22T09:18:18Z" xsd:dateTime [Term] id: CL:4033118 name: thoracic ganglion enkephalin neuron def: "A sympathetic neuron that has the soma located in the thoracic ganglion and expresses the marker enkephalin." [doi:10.1016/0306-4522(81)90126-3, FBC:Autogenerated] subset: human_subset subset: mouse_subset is_a: CL:0011103 ! sympathetic neuron relationship: RO:0002100 UBERON:0000961 ! has soma location thoracic ganglion relationship: RO:0002292 PR:000020924 ! expresses proenkephalin-A proteolytic cleavage product property_value: terms:contributor https://orcid.org/0000-0001-6677-8489 property_value: terms:date "2025-07-22T09:18:18Z" xsd:dateTime [Term] id: CL:4033119 name: thoracic ganglion TH neuron def: "A sympathetic neuron that has the soma located in the thoracic ganglion and expresses the marker tyrosine hydroxylase (TH)." [doi:10.1073/pnas.86.11.4302, FBC:Autogenerated] subset: human_subset subset: mouse_subset is_a: CL:0011103 ! sympathetic neuron relationship: RO:0002100 UBERON:0000961 ! has soma location thoracic ganglion relationship: RO:0002292 PR:000016301 ! expresses tyrosine 3-monooxygenase property_value: terms:contributor https://orcid.org/0000-0001-6677-8489 property_value: terms:date "2025-07-22T09:18:18Z" xsd:dateTime [Term] id: CL:4033120 name: thoracic ganglion TH/NPY neuron def: "A sympathetic neuron that has the soma located in the thoracic ganglion and expresses the marker tyrosine hydroxylase (TH) and neuropeptide Y (NPY)." [doi:10.1073/pnas.86.11.4302, FBC:Autogenerated] subset: human_subset subset: mouse_subset is_a: CL:0011103 ! sympathetic neuron relationship: RO:0002100 UBERON:0000961 ! has soma location thoracic ganglion relationship: RO:0002292 PR:000011387 ! expresses neuropeptide Y relationship: RO:0002292 PR:000016301 ! expresses tyrosine 3-monooxygenase property_value: terms:contributor https://orcid.org/0000-0001-6677-8489 property_value: terms:date "2025-07-22T09:18:18Z" xsd:dateTime [Term] id: CL:4033121 name: lumbar ganglion VIP neuron def: "A sympathetic neuron that has the soma located in the lumbar ganglion and expresses the marker vasoactive intestinal peptide (VIP)." [doi:10.1007/BF00508311, FBC:Autogenerated] subset: human_subset subset: mouse_subset is_a: CL:0011103 ! sympathetic neuron relationship: RO:0002100 UBERON:8600121 ! has soma location lumbar ganglion relationship: RO:0002292 PR:000005404 ! expresses choline O-acetyltransferase relationship: RO:0002292 PR:000017299 ! expresses VIP peptides property_value: terms:contributor https://orcid.org/0000-0001-6677-8489 property_value: terms:date "2025-07-22T09:18:18Z" xsd:dateTime [Term] id: CL:4033122 name: lumbar ganglion SST/TH neuron def: "A sympathetic neuron that has the soma located in the lumbar ganglion and expresses the marker somatostatin (SST) and tyrosine hydroxylase (TH)." [doi:10.1007/BF00215411, FBC:Autogenerated] subset: human_subset subset: mouse_subset is_a: CL:0011103 ! sympathetic neuron relationship: RO:0002100 UBERON:8600121 ! has soma location lumbar ganglion relationship: RO:0002292 PR:000015665 ! expresses somatostatin relationship: RO:0002292 PR:000016301 ! expresses tyrosine 3-monooxygenase property_value: terms:contributor https://orcid.org/0000-0001-6677-8489 property_value: terms:date "2025-07-22T09:18:18Z" xsd:dateTime [Term] id: CL:4033123 name: lumbar ganglion TH/NPY neuron def: "A sympathetic neuron that has the soma located in the lumbar ganglion and expresses the marker tyrosine hydroxylase (TH) and neuropeptide Y (NPY)." [doi:10.1007/BF01885786, FBC:Autogenerated] subset: human_subset subset: mouse_subset is_a: CL:0011103 ! sympathetic neuron relationship: RO:0002100 UBERON:8600121 ! has soma location lumbar ganglion relationship: RO:0002292 PR:000011387 ! expresses neuropeptide Y relationship: RO:0002292 PR:000016301 ! expresses tyrosine 3-monooxygenase property_value: terms:contributor https://orcid.org/0000-0001-6677-8489 property_value: terms:date "2025-07-22T09:18:18Z" xsd:dateTime [Term] id: CL:4033124 name: lumbar ganglion TH neuron def: "A sympathetic neuron that has the soma located in the lumbar ganglion and expresses the marker tyrosine hydroxylase (TH)." [doi:10.1007/BF01885786, FBC:Autogenerated] subset: human_subset subset: mouse_subset is_a: CL:0011103 ! sympathetic neuron relationship: RO:0002100 UBERON:8600121 ! has soma location lumbar ganglion relationship: RO:0002292 PR:000016301 ! expresses tyrosine 3-monooxygenase property_value: terms:contributor https://orcid.org/0000-0001-6677-8489 property_value: terms:date "2025-07-22T09:18:18Z" xsd:dateTime [Term] id: CL:4033125 name: lumbar ganglion NPY neuron def: "A sympathetic neuron that has the soma located in the lumbar ganglion and expresses the marker neuropeptide Y (NPY)." [doi:10.1007/BF01885786, FBC:Autogenerated] subset: human_subset subset: mouse_subset is_a: CL:0011103 ! sympathetic neuron relationship: RO:0002100 UBERON:8600121 ! has soma location lumbar ganglion relationship: RO:0002292 PR:000011387 ! expresses neuropeptide Y property_value: terms:contributor https://orcid.org/0000-0001-6677-8489 property_value: terms:date "2025-07-22T09:18:18Z" xsd:dateTime [Term] id: CL:4033126 name: sacral ganglion TH neuron def: "A sympathetic neuron that has the soma located in the sacral ganglion and expresses the marker tyrosine hydroxylase (TH)." [doi:10.1016/j.eururo.2005.02.010, FBC:Autogenerated] subset: human_subset subset: mouse_subset is_a: CL:0011103 ! sympathetic neuron relationship: RO:0002100 UBERON:8600122 ! has soma location sacral ganglion relationship: RO:0002292 PR:000016301 ! expresses tyrosine 3-monooxygenase property_value: terms:contributor https://orcid.org/0000-0001-6677-8489 property_value: terms:date "2025-07-22T09:18:18Z" xsd:dateTime [Term] id: CL:4033127 name: lower airway ganglion ChAT/VIP neuron def: "A peripheral nervous system neuron that has the soma located in the lower airway ganglion and expresses the marker choline O-acetyltransferase (ChAT) and vasoactive intestinal peptide (VIP)." [doi:10.1111/j.1749-6632.1996.tb17547.x, FBC:Autogenerated] subset: human_subset subset: mouse_subset is_a: CL:0000107 ! autonomic neuron relationship: RO:0002100 UBERON:8600123 ! has soma location lower airway ganglion relationship: RO:0002292 PR:000005404 ! expresses choline O-acetyltransferase relationship: RO:0002292 PR:000017299 ! expresses VIP peptides property_value: terms:contributor https://orcid.org/0000-0001-6677-8489 property_value: terms:date "2025-07-22T09:18:18Z" xsd:dateTime [Term] id: CL:4033128 name: celiac ganglion VIP neuron def: "A sympathetic neuron that has the soma located in the celiac ganglion and expresses the marker vasoactive intestinal peptide (VIP)." [doi:10.1016/0167-0115(93)90051-9, doi:10.1016/0891-0618(93)90030-8, FBC:Autogenerated] subset: human_subset subset: mouse_subset is_a: CL:0011103 ! sympathetic neuron relationship: RO:0002100 UBERON:0002262 ! has soma location celiac ganglion relationship: RO:0002292 PR:000017299 ! expresses VIP peptides property_value: terms:contributor https://orcid.org/0000-0001-6677-8489 property_value: terms:date "2025-07-22T09:18:18Z" xsd:dateTime [Term] id: CL:4033129 name: celiac ganglion PHI neuron def: "A sympathetic neuron that has the soma located in the celiac ganglion and expresses the marker peptide histidine isoleucine (PHI)." [doi:10.1016/0167-0115(93)90051-9, doi:10.1016/0891-0618(93)90030-8, FBC:Autogenerated] subset: human_subset subset: mouse_subset is_a: CL:0011103 ! sympathetic neuron relationship: RO:0002100 UBERON:0002262 ! has soma location celiac ganglion property_value: terms:contributor https://orcid.org/0000-0001-6677-8489 property_value: terms:date "2025-07-22T09:18:18Z" xsd:dateTime [Term] id: CL:4033130 name: celiac ganglion CGRP neuron def: "A sympathetic neuron that has the soma located in the celiac ganglion and expresses the marker calcitonin gene-related peptide (CGRP)." [doi:10.1016/0167-0115(93)90051-9, doi:10.1016/0891-0618(93)90030-8, doi:10.1111/j.1749-6632.1992.tb22804.x, FBC:Autogenerated] subset: human_subset subset: mouse_subset is_a: CL:0011103 ! sympathetic neuron relationship: RO:0002100 UBERON:0002262 ! has soma location celiac ganglion relationship: RO:0002292 PR:000027226 ! expresses calcitonin gene-related peptide 1 property_value: terms:contributor https://orcid.org/0000-0001-6677-8489 property_value: terms:date "2025-07-22T09:18:18Z" xsd:dateTime [Term] id: CL:4033131 name: celiac ganglion SP neuron def: "A sympathetic neuron that has the soma located in the celiac ganglion and expresses the marker substance P (SP)." [doi:10.1016/0167-0115(93)90051-9, doi:10.1016/0891-0618(93)90030-8, FBC:Autogenerated, PMID:2455503] subset: human_subset subset: mouse_subset is_a: CL:0011103 ! sympathetic neuron relationship: RO:0002100 UBERON:0002262 ! has soma location celiac ganglion property_value: terms:contributor https://orcid.org/0000-0001-6677-8489 property_value: terms:date "2025-07-22T09:18:18Z" xsd:dateTime [Term] id: CL:4033132 name: celiac ganglion SOM neuron def: "A sympathetic neuron that has the soma located in the celiac ganglion and expresses the marker somatostatin (SOM)." [doi:10.1016/0167-0115(93)90051-9, doi:10.1016/0891-0618(93)90030-8, FBC:Autogenerated] subset: human_subset subset: mouse_subset is_a: CL:0011103 ! sympathetic neuron relationship: RO:0002100 UBERON:0002262 ! has soma location celiac ganglion relationship: RO:0002292 PR:000015665 ! expresses somatostatin property_value: terms:contributor https://orcid.org/0000-0001-6677-8489 property_value: terms:date "2025-07-22T09:18:18Z" xsd:dateTime [Term] id: CL:4033133 name: celiac ganglion SOM/CGRP neuron def: "A sympathetic neuron that has the soma located in the celiac ganglion and expresses the marker somatostatin (SOM) and calcitonin gene-related peptide (CGRP)." [doi:10.1016/0167-0115(93)90051-9, doi:10.1016/0891-0618(93)90030-8, FBC:Autogenerated] subset: human_subset subset: mouse_subset is_a: CL:0011103 ! sympathetic neuron relationship: RO:0002100 UBERON:0002262 ! has soma location celiac ganglion relationship: RO:0002292 PR:000004973 ! expresses calcitonin gene-related peptide type 1 receptor relationship: RO:0002292 PR:000015665 ! expresses somatostatin property_value: terms:contributor https://orcid.org/0000-0001-6677-8489 property_value: terms:date "2025-07-22T09:18:18Z" xsd:dateTime [Term] id: CL:4033134 name: superior mesenteric ganglion SP neuron def: "A sympathetic neuron that has the soma located in the superior mesenteric ganglion and expresses the marker substance P (SP)." [FBC:Autogenerated, PMID:2455503] subset: human_subset subset: mouse_subset is_a: CL:0011103 ! sympathetic neuron relationship: RO:0002100 UBERON:0005479 ! has soma location superior mesenteric ganglion property_value: terms:contributor https://orcid.org/0000-0001-6677-8489 property_value: terms:date "2025-07-22T09:18:18Z" xsd:dateTime [Term] id: CL:4033135 name: inferior mesenteric ganglion TH neuron def: "A sympathetic neuron that has the soma located in the inferior mesenteric ganglion and expresses the marker tyrosine hydroxylase (TH)." [doi:10.1111/joa.12436, FBC:Autogenerated] subset: human_subset subset: mouse_subset is_a: CL:0011103 ! sympathetic neuron relationship: RO:0002100 UBERON:0005453 ! has soma location inferior mesenteric ganglion relationship: RO:0002292 PR:000016301 ! expresses tyrosine 3-monooxygenase property_value: terms:contributor https://orcid.org/0000-0001-6677-8489 property_value: terms:date "2025-07-22T09:18:18Z" xsd:dateTime [Term] id: CL:4033136 name: inferior mesenteric ganglion SP neuron def: "A sympathetic neuron that has the soma located in the inferior mesenteric ganglion and expresses the marker substance P (SP)." [FBC:Autogenerated, PMID:2455503] subset: human_subset subset: mouse_subset is_a: CL:0011103 ! sympathetic neuron relationship: RO:0002100 UBERON:0005453 ! has soma location inferior mesenteric ganglion property_value: terms:contributor https://orcid.org/0000-0001-6677-8489 property_value: terms:date "2025-07-22T09:18:18Z" xsd:dateTime [Term] id: CL:4033137 name: otic ganglion nNOS neuron def: "A peripheral nervous system neuron that has the soma located in the otic ganglion and expresses the marker neuronal nitric oxide synthase 1 (nNOS)." [doi:10.1002/ar.21516, doi:10.1016/S0006-8993(99)01260-3, FBC:Autogenerated] subset: human_subset subset: mouse_subset is_a: CL:0000107 ! autonomic neuron relationship: RO:0002100 UBERON:0003963 ! has soma location otic ganglion relationship: RO:0002292 PR:000011326 ! expresses nitric oxide synthase 1 property_value: terms:contributor https://orcid.org/0000-0001-6677-8489 property_value: terms:date "2025-07-22T09:18:18Z" xsd:dateTime [Term] id: CL:4033138 name: otic ganglion VIP neuron def: "A peripheral nervous system neuron that has the soma located in the otic ganglion and expresses the marker vasoactive intestinal peptide (VIP)." [doi:10.1016/S0006-8993(99)01260-3, FBC:Autogenerated] subset: human_subset subset: mouse_subset is_a: CL:0000107 ! autonomic neuron relationship: RO:0002100 UBERON:0003963 ! has soma location otic ganglion relationship: RO:0002292 PR:000017299 ! expresses VIP peptides property_value: terms:contributor https://orcid.org/0000-0001-6677-8489 property_value: terms:date "2025-07-22T09:18:18Z" xsd:dateTime [Term] id: CL:4033139 name: ciliary ganglion VIP/PHI neuron def: "A peripheral nervous system neuron that has the soma located in the ciliary ganglion and expresses the marker vasoactive intestinal peptide (VIP) and peptide histidine isoleucine (PHI)." [doi:10.1002/ar.21516, FBC:Autogenerated] subset: human_subset subset: mouse_subset is_a: CL:0000107 ! autonomic neuron relationship: RO:0002100 UBERON:0002058 ! has soma location main ciliary ganglion relationship: RO:0002292 PR:000017299 ! expresses VIP peptides property_value: terms:contributor https://orcid.org/0000-0001-6677-8489 property_value: terms:date "2025-07-22T09:18:18Z" xsd:dateTime [Term] id: CL:4033140 name: ciliary ganglion TH neuron def: "A peripheral nervous system neuron that has the soma located in the ciliary ganglion and expresses the marker tyrosine hydroxylase (TH)." [doi:10.1002/ar.21516, doi:10.1016/0006-8993(95)00299-6, FBC:Autogenerated] subset: human_subset subset: mouse_subset is_a: CL:0000107 ! autonomic neuron relationship: RO:0002100 UBERON:0002058 ! has soma location main ciliary ganglion relationship: RO:0002292 PR:000016301 ! expresses tyrosine 3-monooxygenase property_value: terms:contributor https://orcid.org/0000-0001-6677-8489 property_value: terms:date "2025-07-22T09:18:18Z" xsd:dateTime [Term] id: CL:4033141 name: submandibular ganglion TH cholinergic neuron def: "A peripheral nervous system neuron that has the soma located in the submandibular ganglion and expresses the marker tyrosine hydroxylase (TH)." [doi:10.1002/ar.21516, FBC:Autogenerated] subset: human_subset subset: mouse_subset is_a: CL:0000107 ! autonomic neuron relationship: RO:0002100 UBERON:0002059 ! has soma location submandibular ganglion relationship: RO:0002292 PR:000016301 ! expresses tyrosine 3-monooxygenase property_value: terms:contributor https://orcid.org/0000-0001-6677-8489 property_value: terms:date "2025-07-22T09:18:18Z" xsd:dateTime [Term] id: CL:4033142 name: submandibular ganglion VIP/PHI neuron def: "A peripheral nervous system neuron that has the soma located in the submandibular ganglion and expresses the marker vasoactive intestinal peptide (VIP) and peptide histidine isoleucine (PHI)." [doi:10.1002/ar.21516, FBC:Autogenerated] subset: human_subset subset: mouse_subset is_a: CL:0000107 ! autonomic neuron relationship: RO:0002100 UBERON:0002059 ! has soma location submandibular ganglion relationship: RO:0002292 PR:000017299 ! expresses VIP peptides property_value: terms:contributor https://orcid.org/0000-0001-6677-8489 property_value: terms:date "2025-07-22T09:18:18Z" xsd:dateTime [Term] id: CL:4033143 name: submandibular ganglion nNOS neuron def: "A peripheral nervous system neuron that has the soma located in the submandibular ganglion and expresses the marker neuronal nitric oxide synthase 1 (nNOS)." [doi:10.1002/ar.21516, FBC:Autogenerated] subset: human_subset subset: mouse_subset is_a: CL:0000107 ! autonomic neuron relationship: RO:0002100 UBERON:0002059 ! has soma location submandibular ganglion relationship: RO:0002292 PR:000011326 ! expresses nitric oxide synthase 1 property_value: terms:contributor https://orcid.org/0000-0001-6677-8489 property_value: terms:date "2025-07-22T09:18:18Z" xsd:dateTime [Term] id: CL:4033144 name: pterygopalatine ganglion VIP/PHI neuron def: "A peripheral nervous system neuron that has the soma located in the pterygopalatine ganglion and expresses the marker vasoactive intestinal peptide (VIP) and peptide histidine isoleucine (PHI)." [doi:10.1002/ar.21516, FBC:Autogenerated] subset: human_subset subset: mouse_subset is_a: CL:0000107 ! autonomic neuron relationship: RO:0002100 UBERON:0003962 ! has soma location pterygopalatine ganglion relationship: RO:0002292 PR:000017299 ! expresses VIP peptides property_value: terms:contributor https://orcid.org/0000-0001-6677-8489 property_value: terms:date "2025-07-22T09:18:18Z" xsd:dateTime [Term] id: CL:4033145 name: pterygopalatine ganglion VIP neuron def: "A peripheral nervous system neuron that has the soma located in the pterygopalatine ganglion and expresses the marker vasoactive intestinal peptide (VIP)." [doi:10.1016/S0006-8993(99)01260-3, FBC:Autogenerated] subset: human_subset subset: mouse_subset is_a: CL:0000107 ! autonomic neuron relationship: RO:0002100 UBERON:0003962 ! has soma location pterygopalatine ganglion relationship: RO:0002292 PR:000017299 ! expresses VIP peptides property_value: terms:contributor https://orcid.org/0000-0001-6677-8489 property_value: terms:date "2025-07-22T09:18:18Z" xsd:dateTime [Term] id: CL:4033146 name: pterygopalatine ganglion nNOS neuron def: "A peripheral nervous system neuron that has the soma located in the pterygopalatine ganglion and expresses the marker neuronal nitric oxide synthase 1 (nNOS)." [doi:10.1002/ar.21516, doi:10.1016/S0006-8993(99)01260-3, FBC:Autogenerated] subset: human_subset subset: mouse_subset is_a: CL:0000107 ! autonomic neuron relationship: RO:0002100 UBERON:0003962 ! has soma location pterygopalatine ganglion relationship: RO:0002292 PR:000011326 ! expresses nitric oxide synthase 1 property_value: terms:contributor https://orcid.org/0000-0001-6677-8489 property_value: terms:date "2025-07-22T09:18:18Z" xsd:dateTime [Term] id: CL:4033147 name: vestibular ganglion SP neuron def: "A peripheral nervous system neuron that has the soma located in the vestibular ganglion and expresses the marker substance P (SP)." [doi:10.3109/00016489609137839, FBC:Autogenerated] subset: human_subset subset: mouse_subset is_a: BFO:0000002 is_a: CL:2000032 ! peripheral nervous system neuron relationship: RO:0002100 UBERON:0002824 ! has soma location vestibular ganglion property_value: terms:contributor https://orcid.org/0000-0001-6677-8489 property_value: terms:date "2025-07-22T09:18:18Z" xsd:dateTime [Term] id: CL:4033148 name: nodose ganglion TRPV1 neuron def: "A sensory neuron that has the soma located in the nodose ganglion and expresses the marker transient receptor potential vanilloid 1 (TRPV1)." [doi:10.1007/s10571-014-0062-9, FBC:Autogenerated] subset: human_subset subset: mouse_subset is_a: BFO:0000002 is_a: CL:0000101 ! sensory neuron relationship: RO:0002100 UBERON:0005363 ! has soma location inferior vagus X ganglion relationship: RO:0002292 PR:000001065 ! expresses transient receptor potential cation channel TRPV1 property_value: terms:contributor https://orcid.org/0000-0001-6677-8489 property_value: terms:date "2025-07-22T09:18:18Z" xsd:dateTime [Term] id: CL:4033149 name: nodose ganglion P2X3 neuron def: "A sensory neuron that has the soma located in the nodose ganglion and expresses the marker purinergic receptor P2X3 (P2X3)." [doi:10.1007/s10571-014-0062-9, FBC:Autogenerated] subset: human_subset subset: mouse_subset is_a: BFO:0000002 is_a: CL:0000101 ! sensory neuron relationship: RO:0002100 UBERON:0005363 ! has soma location inferior vagus X ganglion relationship: RO:0002292 PR:000012190 ! expresses P2X purinoceptor 3 property_value: terms:contributor https://orcid.org/0000-0001-6677-8489 property_value: terms:date "2025-07-22T09:18:18Z" xsd:dateTime [Term] id: CL:4033150 name: nodose ganglion TRPV2 neuron def: "A sensory neuron that has the soma located in the nodose ganglion and expresses the marker transient receptor potential vanilloid 2 (TRPV2)." [doi:10.1007/s10571-014-0062-9, FBC:Autogenerated] subset: human_subset subset: mouse_subset is_a: BFO:0000002 is_a: CL:0000101 ! sensory neuron relationship: RO:0002100 UBERON:0005363 ! has soma location inferior vagus X ganglion relationship: RO:0002292 PR:000001064 ! expresses transient receptor potential cation channel TRPV2 property_value: terms:contributor https://orcid.org/0000-0001-6677-8489 property_value: terms:date "2025-07-22T09:18:18Z" xsd:dateTime [Term] id: CL:4033151 name: nodose ganglion PVALB neuron def: "A sensory neuron that has the soma located in the nodose ganglion and expresses the marker parvalbumin (PVALB)." [doi:10.1007/s10571-014-0062-9, FBC:Autogenerated] subset: human_subset subset: mouse_subset is_a: BFO:0000002 is_a: CL:0000101 ! sensory neuron relationship: RO:0002100 UBERON:0005363 ! has soma location inferior vagus X ganglion relationship: RO:0002292 PR:000013502 ! expresses parvalbumin alpha property_value: terms:contributor https://orcid.org/0000-0001-6677-8489 property_value: terms:date "2025-07-22T09:18:18Z" xsd:dateTime [Term] id: CL:4033152 name: jugular ganglion TRPV1 neuron def: "A sensory neuron that has the soma located in the jugular ganglion and expresses the marker transient receptor potential vanilloid 1 (TRPV1)." [doi:10.1016/j.tice.2020.101344, FBC:Autogenerated] subset: human_subset subset: mouse_subset is_a: BFO:0000002 is_a: CL:0000101 ! sensory neuron relationship: RO:0002100 UBERON:0005364 ! has soma location superior vagus X ganglion relationship: RO:0002292 PR:000001065 ! expresses transient receptor potential cation channel TRPV1 property_value: terms:contributor https://orcid.org/0000-0001-6677-8489 property_value: terms:date "2025-07-22T09:18:18Z" xsd:dateTime [Term] id: CL:4033153 name: jugular ganglion TRPV2 neuron def: "A sensory neuron that has the soma located in the jugular ganglion and expresses the marker transient receptor potential vanilloid 2 (TRPV2)." [doi:10.1016/j.tice.2020.101344, FBC:Autogenerated] subset: human_subset subset: mouse_subset is_a: BFO:0000002 is_a: CL:0000101 ! sensory neuron relationship: RO:0002100 UBERON:0005364 ! has soma location superior vagus X ganglion relationship: RO:0002292 PR:000001064 ! expresses transient receptor potential cation channel TRPV2 property_value: terms:contributor https://orcid.org/0000-0001-6677-8489 property_value: terms:date "2025-07-22T09:18:18Z" xsd:dateTime [Term] id: CL:4033154 name: jugular ganglion SP neuron def: "A sensory neuron that has the soma located in the jugular ganglion and expresses the marker substance P (SP)." [doi:10.1016/j.tice.2020.101344, FBC:Autogenerated] subset: human_subset subset: mouse_subset is_a: BFO:0000002 is_a: CL:0000101 ! sensory neuron relationship: RO:0002100 UBERON:0005364 ! has soma location superior vagus X ganglion property_value: terms:contributor https://orcid.org/0000-0001-6677-8489 property_value: terms:date "2025-07-22T09:18:18Z" xsd:dateTime [Term] id: CL:4033155 name: jugular ganglion CGRP neuron def: "A sensory neuron that has the soma located in the jugular ganglion and expresses the marker calcitonin gene-related peptide (CGRP)." [doi:10.1016/j.tice.2020.101344, FBC:Autogenerated] subset: human_subset subset: mouse_subset is_a: BFO:0000002 is_a: CL:0000101 ! sensory neuron relationship: RO:0002100 UBERON:0005364 ! has soma location superior vagus X ganglion relationship: RO:0002292 PR:000027226 ! expresses calcitonin gene-related peptide 1 property_value: terms:contributor https://orcid.org/0000-0001-6677-8489 property_value: terms:date "2025-07-22T09:18:18Z" xsd:dateTime [Term] id: CL:4033156 name: jugular ganglion SPARCL1 neuron def: "A sensory neuron that has the soma located in the jugular ganglion and expresses the marker SPARC-like protein 1 (SPARCL1)." [doi:10.1016/j.tice.2020.101344, FBC:Autogenerated] subset: human_subset subset: mouse_subset is_a: BFO:0000002 is_a: CL:0000101 ! sensory neuron relationship: RO:0002100 UBERON:0005364 ! has soma location superior vagus X ganglion relationship: RO:0002292 PR:000015476 ! expresses SPARC-like protein 1 property_value: terms:contributor https://orcid.org/0000-0001-6677-8489 property_value: terms:date "2025-07-22T09:18:18Z" xsd:dateTime [Term] id: CL:4033157 name: geniculate ganglion TRPV1 neuron def: "A sensory neuron that has the soma located in the geniculate ganglion and expresses the marker transient receptor potential vanilloid 1 (TRPV1)." [doi:10.1159/000470835, FBC:Autogenerated] subset: human_subset subset: mouse_subset is_a: BFO:0000002 is_a: CL:0000101 ! sensory neuron relationship: RO:0002100 UBERON:0001700 ! has soma location geniculate ganglion relationship: RO:0002292 PR:000001065 ! expresses transient receptor potential cation channel TRPV1 property_value: terms:contributor https://orcid.org/0000-0001-6677-8489 property_value: terms:date "2025-07-22T09:18:18Z" xsd:dateTime [Term] id: CL:4033158 name: geniculate ganglion SPARCL1 neuron def: "A sensory neuron that has the soma located in the geniculate ganglion and expresses the marker SPARC-like protein 1 (SPARCL1)." [doi:10.1159/000470835, FBC:Autogenerated] subset: human_subset subset: mouse_subset is_a: BFO:0000002 is_a: CL:0000101 ! sensory neuron relationship: RO:0002100 UBERON:0001700 ! has soma location geniculate ganglion relationship: RO:0002292 PR:000015476 ! expresses SPARC-like protein 1 property_value: terms:contributor https://orcid.org/0000-0001-6677-8489 property_value: terms:date "2025-07-22T09:18:18Z" xsd:dateTime [Term] id: CL:4033159 name: geniculate ganglion VGLUT2 neuron def: "A sensory neuron that has the soma located in the geniculate ganglion and expresses the marker vesicular glutamate transporter 2 (VGLUT2)." [doi:10.1159/000470835, FBC:Autogenerated] subset: human_subset subset: mouse_subset is_a: BFO:0000002 is_a: CL:0000101 ! sensory neuron relationship: RO:0002100 UBERON:0001700 ! has soma location geniculate ganglion relationship: RO:0002292 PR:000014962 ! expresses vesicular glutamate transporter 2 property_value: terms:contributor https://orcid.org/0000-0001-6677-8489 property_value: terms:date "2025-07-22T09:18:18Z" xsd:dateTime [Term] id: CL:4033160 name: myenteric ganglion of small intestine ChAT neuron def: "A peripheral nervous system neuron that has the soma located in the myenteric ganglion of the small intestine and expresses the marker choline O-acetyltransferase (ChAT)." [doi:10.1007/s00418-021-02002-y, doi:10.1016/j.jcmgh.2023.06.010, FBC:Autogenerated] subset: human_subset subset: mouse_subset is_a: CL:0007011 ! enteric neuron relationship: RO:0002100 UBERON:8600119 ! has soma location myenteric ganglion of small intestine relationship: RO:0002292 PR:000005404 ! expresses choline O-acetyltransferase property_value: terms:contributor https://orcid.org/0000-0001-6677-8489 property_value: terms:date "2025-07-22T09:18:18Z" xsd:dateTime [Term] id: CL:4033161 name: myenteric ganglion of small intestine nNOS neuron def: "A peripheral nervous system neuron that has the soma located in the myenteric ganglion of the small intestine and expresses the marker neuronal nitric oxide synthase 1 (nNOS)." [doi:10.1007/s00418-021-02002-y , doi:10.1016/j.jcmgh.2023.06.010, doi:10.1159/000320542, FBC:Autogenerated] subset: human_subset subset: mouse_subset is_a: CL:0007011 ! enteric neuron relationship: RO:0002100 UBERON:8600119 ! has soma location myenteric ganglion of small intestine relationship: RO:0002292 PR:000011326 ! expresses nitric oxide synthase 1 property_value: terms:contributor https://orcid.org/0000-0001-6677-8489 property_value: terms:date "2025-07-22T09:18:18Z" xsd:dateTime [Term] id: CL:4033162 name: myenteric ganglion of small intestine VIP neuron def: "A peripheral nervous system neuron that has the soma located in the myenteric ganglion of the small intestine and expresses the marker vasoactive intestinal peptide (VIP)." [doi:10.1016/j.jcmgh.2023.06.010, FBC:Autogenerated] subset: human_subset subset: mouse_subset is_a: CL:0007011 ! enteric neuron relationship: RO:0002100 UBERON:8600119 ! has soma location myenteric ganglion of small intestine relationship: RO:0002292 PR:000017299 ! expresses VIP peptides property_value: terms:contributor https://orcid.org/0000-0001-6677-8489 property_value: terms:date "2025-07-22T09:18:18Z" xsd:dateTime [Term] id: CL:4033163 name: myenteric ganglion of small intestine nNOS/VIP neuron def: "A peripheral nervous system neuron that has the soma located in the myenteric ganglion of the small intestine and expresses the marker neuronal nitric oxide synthase 1 (nNOS) and vasoactive intestinal peptide (VIP)." [10.1007/s00418-005-0107-8, doi:10.1007/s00418-021-02002-y, doi:10.1159/000320542, FBC:Autogenerated] subset: human_subset subset: mouse_subset is_a: CL:0007011 ! enteric neuron relationship: RO:0002100 UBERON:8600119 ! has soma location myenteric ganglion of small intestine relationship: RO:0002292 PR:000011326 ! expresses nitric oxide synthase 1 relationship: RO:0002292 PR:000017299 ! expresses VIP peptides property_value: terms:contributor https://orcid.org/0000-0001-6677-8489 property_value: terms:date "2025-07-22T09:18:18Z" xsd:dateTime [Term] id: CL:4033164 name: myenteric ganglion of small intestine nNOS/ChAT neuron def: "A peripheral nervous system neuron that has the soma located in the myenteric ganglion of the small intestine and expresses the marker neuronal nitric oxide synthase 1 (nNOS) and choline O-acetyltransferase (ChAT)." [doi:10.1007/s00418-021-02002-y, doi:10.1007/s00441-009-0852-4, FBC:Autogenerated] subset: human_subset subset: mouse_subset is_a: CL:0007011 ! enteric neuron relationship: RO:0002100 UBERON:8600119 ! has soma location myenteric ganglion of small intestine relationship: RO:0002292 PR:000005404 ! expresses choline O-acetyltransferase relationship: RO:0002292 PR:000011326 ! expresses nitric oxide synthase 1 property_value: terms:contributor https://orcid.org/0000-0001-6677-8489 property_value: terms:date "2025-07-22T09:18:18Z" xsd:dateTime [Term] id: CL:4033165 name: myenteric ganglion of small intestine ChAT/CALR/SOM/SP neuron def: "A peripheral nervous system neuron that has the soma located in the myenteric ganglion of the small intestine and expresses the marker choline acetyltransferase (ChAT), calreticulin (CALR), somatostatin (SOM), and substance P (SP)." [doi:10.1007/s00418-007-0335-1, doi:10.1007/s00418-021-02002-y, FBC:Autogenerated] subset: human_subset subset: mouse_subset is_a: CL:0007011 ! enteric neuron relationship: RO:0002100 UBERON:8600119 ! has soma location myenteric ganglion of small intestine relationship: RO:0002292 PR:000004984 ! expresses calreticulin relationship: RO:0002292 PR:000005404 ! expresses choline O-acetyltransferase relationship: RO:0002292 PR:000015665 ! expresses somatostatin property_value: terms:contributor https://orcid.org/0000-0001-6677-8489 property_value: terms:date "2025-07-22T09:18:18Z" xsd:dateTime [Term] id: CL:4033166 name: myenteric ganglion of small intestine VIP/GAL neuron def: "A peripheral nervous system neuron that has the soma located in the myenteric ganglion of the small intestine and expresses the marker vasoactive intestinal peptide (VIP) and galanin (GAL)." [doi:10.1159/000320542, FBC:Autogenerated] subset: human_subset subset: mouse_subset is_a: CL:0007011 ! enteric neuron relationship: RO:0002100 UBERON:8600119 ! has soma location myenteric ganglion of small intestine relationship: RO:0002292 PR:000007806 ! expresses galanin relationship: RO:0002292 PR:000017299 ! expresses VIP peptides property_value: terms:contributor https://orcid.org/0000-0001-6677-8489 property_value: terms:date "2025-07-22T09:18:18Z" xsd:dateTime [Term] id: CL:4033167 name: pelvic ganglion TH neuron def: "A peripheral nervous system neuron that has the soma located in the pelvic ganglion and expresses the marker tyrosine hydroxylase (TH)." [doi:10.1016/j.eururo.2005.02.010, doi:10.1111/j.1469-7580.2009.01071.x, doi:10.1186/s12894-018-0369-9, FBC:Autogenerated] subset: human_subset subset: mouse_subset is_a: CL:0000107 ! autonomic neuron relationship: RO:0002100 UBERON:0016508 ! has soma location pelvic ganglion relationship: RO:0002292 PR:000016301 ! expresses tyrosine 3-monooxygenase property_value: terms:contributor https://orcid.org/0000-0001-6677-8489 property_value: terms:date "2025-07-22T09:18:18Z" xsd:dateTime [Term] id: CL:4033168 name: pelvic ganglion TH/DBH neuron def: "A peripheral nervous system neuron that has the soma located in the pelvic ganglion and expresses the marker tyrosine hydroxylase (TH) and dopamine beta-hydroxylase (DBH)." [doi:10.1007/s00441-020-03279-6, FBC:Autogenerated] subset: human_subset subset: mouse_subset is_a: CL:0000107 ! autonomic neuron relationship: RO:0002100 UBERON:0016508 ! has soma location pelvic ganglion relationship: RO:0002292 PR:000006294 ! expresses dopamine beta-hydroxylase relationship: RO:0002292 PR:000016301 ! expresses tyrosine 3-monooxygenase property_value: terms:contributor https://orcid.org/0000-0001-6677-8489 property_value: terms:date "2025-07-22T09:18:18Z" xsd:dateTime [Term] id: CL:4033169 name: pelvic ganglion VAChT neuron def: "A peripheral nervous system neuron that has the soma located in the pelvic ganglion and expresses the marker vesicular acetylcholine transporter (VAChT)." [doi:10.1111/j.1469-7580.2009.01071.x, FBC:Autogenerated] subset: human_subset subset: mouse_subset is_a: CL:0000107 ! autonomic neuron relationship: RO:0002100 UBERON:0016508 ! has soma location pelvic ganglion relationship: RO:0002292 PR:000014968 ! expresses vesicular acetylcholine transporter property_value: terms:contributor https://orcid.org/0000-0001-6677-8489 property_value: terms:date "2025-07-22T09:18:18Z" xsd:dateTime [Term] id: CL:4033170 name: pelvic ganglion nNOS neuron def: "A peripheral nervous system neuron that has the soma located in the pelvic ganglion and expresses the marker neuronal nitric oxide synthase 1 (nNOS)." [doi:10.1002/(SICI)1520-6777(2000)19\:2%3C185\:\:AID-NAU9%3E3.0.CO;2-2, doi:10.1186/s12894-018-0369-9, FBC:Autogenerated] subset: human_subset subset: mouse_subset is_a: CL:0000107 ! autonomic neuron relationship: RO:0002100 UBERON:0016508 ! has soma location pelvic ganglion relationship: RO:0002292 PR:000011326 ! expresses nitric oxide synthase 1 property_value: terms:contributor https://orcid.org/0000-0001-6677-8489 property_value: terms:date "2025-07-22T09:18:18Z" xsd:dateTime [Term] id: CL:4033171 name: pelvic ganglion nNOS/VIP neuron def: "A peripheral nervous system neuron that has the soma located in the pelvic ganglion and expresses the marker neuronal nitric oxide synthase (nNOS) 1 and vasoactive intestinal peptide (VIP)." [doi:10.1186/s12894-018-0369-9, FBC:Autogenerated] subset: human_subset subset: mouse_subset is_a: CL:0000107 ! autonomic neuron relationship: RO:0002100 UBERON:0016508 ! has soma location pelvic ganglion relationship: RO:0002292 PR:000011326 ! expresses nitric oxide synthase 1 relationship: RO:0002292 PR:000017299 ! expresses VIP peptides property_value: terms:contributor https://orcid.org/0000-0001-6677-8489 property_value: terms:date "2025-07-22T09:18:18Z" xsd:dateTime [Term] id: CL:4033172 name: pelvic ganglion NPY/VAChT neuron def: "A peripheral nervous system neuron that has the soma located in the pelvic ganglion and expresses the marker neuropeptide Y (NPY) and vesicular acetylcholine transporter (VAChT)." [doi:10.1002/(SICI)1520-6777(2000)19\:2%3C185\:\:AID-NAU9%3E3.0.CO;2-2, FBC:Autogenerated] subset: human_subset subset: mouse_subset is_a: CL:0000107 ! autonomic neuron relationship: RO:0002100 UBERON:0016508 ! has soma location pelvic ganglion relationship: RO:0002292 PR:000011387 ! expresses neuropeptide Y relationship: RO:0002292 PR:000014968 ! expresses vesicular acetylcholine transporter property_value: terms:contributor https://orcid.org/0000-0001-6677-8489 property_value: terms:date "2025-07-22T09:18:18Z" xsd:dateTime [Term] id: CL:4033173 name: pelvic ganglion nNOS/VAChT neuron def: "A peripheral nervous system neuron that has the soma located in the pelvic ganglion and expresses the marker neuronal nitric oxide synthase 1(nNOS) and vesicular acetylcholine transporter (VAChT)." [doi:10.1002/(SICI)1520-6777(2000)19\:2<185\:\:AID-NAU9>3.0.CO;2-2, FBC:Autogenerated] subset: human_subset subset: mouse_subset is_a: CL:0000107 ! autonomic neuron relationship: RO:0002100 UBERON:0016508 ! has soma location pelvic ganglion relationship: RO:0002292 PR:000011326 ! expresses nitric oxide synthase 1 relationship: RO:0002292 PR:000014968 ! expresses vesicular acetylcholine transporter property_value: terms:contributor https://orcid.org/0000-0001-6677-8489 property_value: terms:date "2025-07-22T09:18:18Z" xsd:dateTime [Term] id: CL:4033174 name: ovarian nerve plexus ganglion TH neuron def: "A peripheral nervous system neuron that has the soma located in the ovarian nerve plexus ganglion and expresses the marker tyrosine hydroxylase (TH)." [doi:10.1111/joa.12436, FBC:Autogenerated] subset: human_subset subset: mouse_subset is_a: BFO:0000002 is_a: CL:2000032 ! peripheral nervous system neuron relationship: RO:0002292 PR:000016301 ! expresses tyrosine 3-monooxygenase property_value: terms:contributor https://orcid.org/0000-0001-6677-8489 property_value: terms:date "2025-07-22T09:18:18Z" xsd:dateTime [Term] id: CL:4040000 name: glial restricted tripotential precursor cell def: "A glial precursor cell that generates oligodendrocytes and type-1 and type-2 astrocytes. It has been shown in some mammals that this cell type may express A2B5, nestin, FGFR-1, FGFR-2, FGFR-3, PLP, and DM-20 antigens. Unlike oligodendrocyte precursor cell, it does not initially express PDGFR-alpha and can differentiate into both type-1 and type-2 astrocytes." [PMID:10719353] subset: human_subset subset: mouse_subset synonym: "glial restricted precursor" BROAD [PMID:10719353] synonym: "GRP cell" RELATED OMO:0003000 [PMID:11756508] synonym: "tripotential glial-restricted precursor cell" EXACT [PMID:11921204] is_a: CL:0000123 ! neuron associated cell (sensu Vertebrata) is_a: CL:0011115 ! precursor cell property_value: terms:contributor https://orcid.org/0000-0002-0819-0473 property_value: terms:date "2023-04-03T14:54:32Z" xsd:dateTime [Term] id: CL:4040001 name: chorionic girdle cell def: "A horse-specific, highly invasive trophoblast cell that invades the endometrium where it forms endometrial cups." [PMID:27280409, PMID:35328607] comment: Humans, mice and rats have a highly invasive (hemochorial) placentation. Horses have a non-invasive epitheliochorial placenta, except for the transient endometrial cup. {xref="PMID:27280409"} subset: human_subset subset: mouse_subset synonym: "equine chorionic girdle cell" EXACT [PMID:35328607] is_a: CL:0011101 ! chorionic trophoblast cell property_value: RO:0002175 NCBITaxon:9789 property_value: terms:contributor https://orcid.org/0000-0002-0819-0473 property_value: terms:date "2023-04-03T15:08:05Z" xsd:dateTime [Term] id: CL:4040002 name: enteroglial cell def: "Glial cell that provides support to the enteric nervous system. It is involved in enteric neurotransmission, in maintaining the integrity of the mucosal barrier of the gut and serves as a link between the nervous and immune systems of the gut. In enteric nerve strands, glial processes ensheath multiaxonal bundles which distinguishes enteric glia from all other peripheral glia. Ultrastructurally, the most conspicuous trait of an enteroglial cell is the presence of 10 nm filaments, which criss-cross the cell body, form axial bundles in the processes and appear to firmly anchor the cells to the ganglionic surfaces. Similar to astrocytes, their main constituent is glial fibrillary acidic protein (GFAP)." [PMID:16336493, PMID:17483847, PMID:25975510] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "enteric glia" RELATED OMO:0003004 [PMID:11169131] synonym: "enteric glial cell" EXACT [PMID:11169131, PMID:25170211] is_a: CL:0000125 ! glial cell intersection_of: CL:0000125 ! glial cell intersection_of: BFO:0000050 UBERON:0002005 ! part of enteric nervous system relationship: BFO:0000050 UBERON:0002005 ! part of enteric nervous system relationship: RO:0002292 PR:000007939 ! expresses glial fibrillary acidic protein property_value: terms:contributor https://orcid.org/0000-0002-0819-0473 property_value: terms:date "2023-04-03T15:15:40Z" xsd:dateTime [Term] id: CL:4040003 name: fetal pre-type II pulmonary alveolar epithelial cell def: "Precursor of type II pneumocyte. These cells do not have lamellar bodies, which are a marker of type II pneumocyte maturity." [PMID:1316350] comment: According to PMID:1316350 this cell type does not yet produce surfactant. According to PMID:9109447 and PMID:12114192 this cell type produces low levels of surfactant that can be increased by administration of very low-density lipoproteins. This cell type is of medical relevance, as a central feature of the fetal respiratory distress syndrome seems to be the presence in the lung of abundant pre-type II alveolar epithelial cells (PMID:1316350). subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "fetal alveolar pre-type II epithelial cell" EXACT [PMID:9624168] synonym: "fetal pre-type 2 pneumocyte" EXACT [https://orcid.org/0000-0002-0819-0473] synonym: "fetal pre-type II alveolar epithelial cell" EXACT [PMID:12114192] synonym: "fetal pre-type II pneumocyte" EXACT [] is_a: CL:0000322 ! pulmonary alveolar epithelial cell property_value: terms:contributor https://orcid.org/0000-0002-0819-0473 property_value: terms:date "2023-06-02T09:19:31Z" xsd:dateTime [Term] id: CL:4040004 name: mesenchymal stem cell of orbital adipose tissue def: "Any mesenchymal stem cell of adipose tissue that is part of an orbital region." [https://orcid.org/0000-0002-0819-0473] subset: human_subset subset: mouse_subset synonym: "OAMSC" EXACT [PMID:31377878] synonym: "orbital adipose-derived mesenchymal stem cell" EXACT [PMID:31377878] synonym: "Orbital ASCs" EXACT [PMID:30210548] is_a: CL:0002570 ! mesenchymal stem cell of adipose tissue intersection_of: CL:0002570 ! mesenchymal stem cell of adipose tissue intersection_of: BFO:0000050 UBERON:0004088 ! part of orbital region relationship: BFO:0000050 UBERON:0004088 ! part of orbital region property_value: terms:contributor https://orcid.org/0000-0002-0819-0473 property_value: terms:date "2023-09-18T10:43:00Z" xsd:dateTime [Term] id: CL:4040005 name: mesenchymal stem cell of apical papilla def: "A mesenchymal stem cell that is part of the apical papilla tooth root." [PMID:30834270, PMID:34026757] comment: The mesenchymal stem cells of the apical papilla have high capacity for osteogenic, adipogenic, and chondrogenic differentiation. {xref="PMID:34026757"} subset: human_subset subset: mouse_subset synonym: "SCAP" RELATED OMO:0003000 [PMID:37887345] synonym: "SCAPs" RELATED OMO:0003004 [PMID:30834270] synonym: "stem cells from the apical papilla" BROAD OMO:0003004 [PMID:30834270] is_a: CL:0000134 ! mesenchymal stem cell relationship: BFO:0000050 UBERON:0003677 ! part of tooth root property_value: terms:contributor https://orcid.org/0000-0002-0819-0473 property_value: terms:date "2023-11-02T09:44:47Z" xsd:dateTime [Term] id: CL:4040006 name: dermal chromatophore def: "A chromatophore that is part of the dermis." [PMID:28553007] subset: human_subset subset: mouse_subset is_a: CL:0000147 ! pigment cell is_a: CL:0000255 ! eukaryotic cell relationship: BFO:0000050 UBERON:0002067 ! part of dermis property_value: terms:contributor https://orcid.org/0000-0002-0819-0473 property_value: terms:date "2024-03-07T09:37:14Z" xsd:dateTime [Term] id: CL:4042001 name: TAC3-positive striatal interneuron def: "A GABAergic interneuron that has its soma located in the striatum and that has an enriched expression of the genes TAC3 and LHX6." [PMID:32999462, PMID:34727523] subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "TAC3 interneuron" EXACT [PMID:34727523] is_a: CL:0002613 ! striatum neuron is_a: CL:0011005 ! GABAergic interneuron relationship: RO:0002104 PR:000016004 ! has plasma membrane part tachykinin-3 property_value: RO:0002175 NCBITaxon:9606 property_value: terms:contributor https://orcid.org/0000-0002-0098-8958 property_value: terms:date "2024-03-05T14:29:32Z" xsd:dateTime [Term] id: CL:4042002 name: TAC3-positive medium spiny neuron def: "A nucleus accumbens shell and olfactory tubercle D1 medium spiny neuron that co-expresses TAC3 and the DRD1 receptor." [PMID:34727523] comment: A TAC3-positive medium spiny neuron has its soma in a cluster in the medial shell region of the nucleus accumbens. In Rhesus Macaque, this medium spiny neuron has an enriched expression of the genes MPPED1, HPCAL1, MEIS3. {xref="PMID:34727523"} subset: human_subset subset: mouse_subset synonym: "D1Sh TAC3 archetype" RELATED OMO:0003000 [PMID:34727523] synonym: "TAC3-positive D1Sh-MSN" RELATED OMO:0003000 [PMID:34727523] synonym: "TAC3-positive MSN" RELATED OMO:0003000 [PMID:34727523] is_a: CL:4030051 ! nucleus accumbens shell and olfactory tubercle D1 medium spiny neuron relationship: RO:0002104 PR:000016004 ! has plasma membrane part tachykinin-3 property_value: terms:contributor https://orcid.org/0000-0002-0098-8958 property_value: terms:date "2024-03-05T13:36:54Z" xsd:dateTime [Term] id: CL:4042003 name: border associated macrophage def: "A central nervous system macrophage that is part of a choroid plexus, a meninx and a perivascular space. A border associated macrophage interacts with various components of the CNS vasculature and meninges, it participates in immune surveillance and in the regulation of the blood brain barrier." [PMID:37232741, PMID:37626977] comment: In humans, a border associate macrophage expresses CD45 and CD11B. This cell is also known to have the following molecular signature: CD206, CD38, LYVE1, CD163, CD169. {xref="PMID:29426702", xref="PMID:37232741"} subset: human_subset subset: mouse_subset synonym: "BAM" RELATED OMO:0003000 [PMID:36945367] synonym: "CAM" RELATED OMO:0003000 [PMID:33556248] synonym: "CNS-associated macrophage" RELATED [PMID:37232741] is_a: CL:0000878 ! central nervous system macrophage property_value: terms:contributor https://orcid.org/0000-0002-0098-8958 property_value: terms:date "2024-03-26T16:39:56Z" xsd:dateTime [Term] id: CL:4042004 name: choroid epiplexus macrophage def: "A choroid plexus macrophage that is part of the apical surface of some choroid plexus epithelium. This macrophage has a star-like shaped body." [PMID:31061494, PMID:37232741] subset: human_subset subset: mouse_subset synonym: "cpepiMΦ" RELATED OMO:0003000 [PMID:38347231] synonym: "epiplexus cpMΦ" RELATED OMO:0003000 [PMID:38347231] synonym: "Kolmer’s cell" EXACT [PMID:31433571] is_a: CL:0000880 ! choroid plexus macrophage relationship: BFO:0000050 UBERON:0003911 ! part of choroid plexus epithelium property_value: terms:contributor https://orcid.org/0000-0002-0098-8958 property_value: terms:date "2024-03-26T19:14:58Z" xsd:dateTime [Term] id: CL:4042005 name: stromal choroid plexus macrophage def: "A choroid plexus macrophage that is part of a choroid plexus stroma." [PMID:38347231] subset: human_subset subset: mouse_subset synonym: "cpstMΦ" RELATED OMO:0003000 [PMID:37626977] synonym: "stromal cpMΦ" RELATED OMO:0003000 [PMID:37232741, PMID:38347231] is_a: CL:0000880 ! choroid plexus macrophage relationship: BFO:0000050 UBERON:0005206 ! part of choroid plexus stroma property_value: terms:contributor https://orcid.org/0000-0002-0098-8958 property_value: terms:date "2024-03-26T19:21:51Z" xsd:dateTime [Term] id: CL:4042006 name: dural macrophage def: "A border associated macrophage which is part of a dura matter. This macrophage phagocytoses intruding pathogens and foreign molecules detected in the bloodstream or in the cerebrospinal fluid. This cell has an amoeboid body with dynamic protrusions in homeostasis." [PMID:31061494] subset: human_subset subset: mouse_subset synonym: "dmMΦ" RELATED OMO:0003000 [PMID:37232741] is_a: CL:4042003 ! border associated macrophage relationship: BFO:0000050 UBERON:0002092 ! part of brain dura mater property_value: terms:contributor https://orcid.org/0000-0002-0098-8958 property_value: terms:date "2024-03-26T19:27:03Z" xsd:dateTime [Term] id: CL:4042007 name: protoplasmic astrocyte def: "An astrocyte with highly branched protrusions, found in neocortex layers 2-6. It is involved with the formation and elimination of synapses, glutamate clearance, modulation of synaptic functions and regulation of blood flow in response to synaptic activity." [PMID:19279265, PMID:25904839, PMID:34616062, PMID:37139179, PMID:37824655] comment: This astrocyte extends its branches to several hundred of dendrites to multiple neurons to envelope 100,000 or more synapses. In humans, a protoplasmic astrocyte has an average diameter of 142 µm, and its diameter ranges between 100 and 400 µm. In rodents the average diameter of a protoplasmic astrocites is 56 µm. {xref="PMID:20012068", xref="PMID:19279265"} subset: human_subset subset: mouse_subset is_a: CL:0002605 ! astrocyte of the cerebral cortex relationship: BFO:0000050 UBERON:0001950 ! part of neocortex property_value: terms:contributor https://orcid.org/0000-0002-0098-8958 property_value: terms:date "2024-04-08T16:01:24Z" xsd:dateTime [Term] id: CL:4042008 name: fibrous astrocyte def: "A cell type located in the first layer of the neocortex with radial protrusions extending transversely into the deeper cortex layers, herby facilitating communication across neurons, astrocytes, capillaries, meninges and cerebrospinal fluid through contact with neurons, pia mater and capillaries." [PMID:19279265, PMID:22144298, PMID:28280934, PMID:31435019, PMID:34616062, PMID:37824655] comment: In humans, a fibrous astrocyte diameter is circa 182 µm. In rodents, a fibrous astrocyte diameter is circa 85 µm. {xref="PMID:28280934"} subset: human_subset subset: mouse_subset is_a: CL:0000127 ! astrocyte relationship: BFO:0000050 UBERON:0002316 ! part of white matter property_value: terms:contributor https://orcid.org/0000-0002-0098-8958 property_value: terms:date "2024-04-08T16:29:28Z" xsd:dateTime [Term] id: CL:4042009 name: interlaminar astrocyte def: "An astrocyte type that presents radial protrusions across the layers of a cortex. The soma of this astrocyte is part of the first layer of a neocortex. This astrocyte extents its protrusions transversally to the deeper layers of a cortex and it creates contact with neurons, the pia matter and capillaries. This astrocyte is involved in facilitating the communication across neurons, astrocytes, capillaries, meninges and the cerebrospinal fluid." [PMID:19279265, PMID:30552685, PMID:31435019, PMID:32930323, PMID:34616062, PMID:37824655] subset: human_subset subset: mouse_subset synonym: "ILA" RELATED OMO:0003000 [PMID:30552685] is_a: CL:0002605 ! astrocyte of the cerebral cortex relationship: BFO:0000050 UBERON:0001950 ! part of neocortex property_value: terms:contributor https://orcid.org/0000-0002-0098-8958 property_value: terms:date "2024-04-08T16:33:45Z" xsd:dateTime [Term] id: CL:4042010 name: pial interlaminar astrocyte def: "An interlaminar astrocyte whose soma is part of the first layer of a neocortex and is in contact with a pia surface." [PMID:32930323, PMID:37139179] subset: human_subset subset: mouse_subset is_a: CL:4042009 ! interlaminar astrocyte property_value: terms:contributor https://orcid.org/0000-0002-0098-8958 property_value: terms:date "2024-04-08T16:37:57Z" xsd:dateTime [Term] id: CL:4042011 name: subpial interlaminar astrocyte def: "An interlaminar astrocyte type whose soma is part of the upper first layer of the neocortex and its processes extend to a pia surface." [PMID:32930323, PMID:37139179] subset: human_subset subset: mouse_subset is_a: CL:4042009 ! interlaminar astrocyte relationship: RO:0002170 UBERON:0002361 ! connected to pia mater property_value: terms:contributor https://orcid.org/0000-0002-0098-8958 property_value: terms:date "2024-04-08T16:39:09Z" xsd:dateTime [Term] id: CL:4042012 name: L2 marginal neuron def: "An L2 intratelencephalic projecting glutamatergic neuron with a soma on the L1-L2 border. This neuron type has small apical dendrites projecting to L1." [PMID:29311847, PMID:32108571] subset: human_subset subset: mouse_subset synonym: "L2MN" RELATED OMO:0003000 [PMID:29311847, PMID:32108571] synonym: "layer 2 marginal neuron" EXACT [PMID:32108571] is_a: CL:4030060 ! L2 intratelencephalic projecting glutamatergic neuron property_value: IAO:0000028 "L2MN" xsd:string property_value: terms:contributor https://orcid.org/0000-0002-0098-8958 property_value: terms:date "2024-04-23T09:31:39Z" xsd:dateTime [Term] id: CL:4042013 name: Lamp5 Lhx6 neuron def: "A transcriptomically distinct GABAergic interneuron marked by Lamp5 and Lhx6 expression, derived from the Medial Ganglionic Eminence (MGE), and located in the pallium." [https://cellxgene.cziscience.com/e/e4ddac12-f48f-4455-8e8d-c2a48a683437.cxg/, PMID:34004146, PMID:36007006, PMID:37824655, PMID:37824669] comment: The marker set CHST9, LAMP5 can identify the Human cell type Lamp5 Lhx6 neuron in the neocortex with a confidence of 0.821678322 (NS-Forest FBeta value). {xref="https://doi.org/10.5281/zenodo.11165918"} subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "Ivy cell" EXACT [PMID:36007006] synonym: "Lamp5-Lhx6 type" EXACT [PMID:30382198] is_a: CL:4023011 ! lamp5 GABAergic interneuron is_a: CL:4023069 ! medial ganglionic eminence derived GABAergic interneuron relationship: RO:0002292 PR:000032533 ! expresses LIM/homeobox protein Lhx6 relationship: RO:0015004 CLM:1000075 ! has characterizing marker set NS forest marker set of Lamp5 Lhx6 neuron (Human neocortex). property_value: RO:0002175 NCBITaxon:9606 property_value: terms:contributor https://orcid.org/0000-0002-0098-8958 property_value: terms:date "2024-04-23T09:37:55Z" xsd:dateTime [Term] id: CL:4042014 name: spiny VIP neuron def: "A VIP GABAergic cortical interneuron with a soma located in L1-3 of some neocortex in Mmus. This neuron has a multipolar morphology with spiny dendrites concentrating on L1 of the cortex, and has a burst firing electrophysiological signature with highly dynamic dendritic spines." [PMID:35418660] subset: human_subset subset: mouse_subset synonym: "multipolar VIP neuron" RELATED [PMID:35418660] synonym: "superficial VIP-positive spiny neuron" EXACT [PMID:35418660] is_a: CL:4023016 ! VIP GABAergic interneuron relationship: BFO:0000050 UBERON:0001950 ! part of neocortex property_value: terms:contributor https://orcid.org/0000-0002-0098-8958 property_value: terms:date "2024-07-11T12:09:53Z" xsd:dateTime [Term] id: CL:4042015 name: VIP-ChAT interneuron def: "A VIP GABAergic cortical interneuron expressing vasoactive intestinal polypeptide and choline acetyltransferase in the Mmus neocortex. This interneuron releases both γ-aminobutyric acid and acetylcholine." [PMID:30382198, PMID:31754098, PMID:32027647, PMID:33301603] comment: Work in the mouse barrel cortex and somatosensory cortex shows that a VIP-ChAT interneuron is predominantely located in L2/3 and more rarely in the deeper layers of the cortex (Dudai et al., 2021; Dudai et al., 2020). This neuronal type could be transcriptomically distinct as transcriptomic studies have identified VIP neurons expressing ChAT in a whole brain mouse transcriptomic study (Tasic et al., 2018). {xref="PMID:30382198", xref="PMID:32027647", xref="PMID:33301603"} subset: human_subset subset: mouse_subset synonym: "VChI" RELATED OMO:0003000 [PMID:32027647] synonym: "VIP+/ChAT+ cell" RELATED [PMID:33301603] synonym: "VIP+/ChAT+ interneuron" EXACT [PMID:33301603] synonym: "VIP/ChAT interneuron" EXACT [PMID:32027647] is_a: CL:0008061 ! GABA-Chol neuron is_a: CL:4023016 ! VIP GABAergic interneuron property_value: terms:contributor https://orcid.org/0000-0002-0098-8958 property_value: terms:date "2024-07-11T12:22:48Z" xsd:dateTime [Term] id: CL:4042016 name: nasal serous secreting cell def: "A serous secreting cell that is part of a submucosal gland in the nasal cavity respiratory epithelium." [PMID:37291214] subset: human_subset subset: mouse_subset synonym: "nasal mucous secretory cell" RELATED [PMID:11005715] xref: https://cellxgene.cziscience.com/e/9f222629-9e39-47d0-b83f-e08d610c7479.cxg/ is_a: CL:0000152 ! exocrine cell is_a: CL:0000313 ! serous secreting cell relationship: BFO:0000050 UBERON:0005385 ! part of nasal cavity respiratory epithelium relationship: BFO:0000050 UBERON:0011148 ! part of submucosal gland property_value: terms:contributor https://orcid.org/0000-0002-0098-8958 property_value: terms:date "2024-07-12T10:58:06Z" xsd:dateTime [Term] id: CL:4042017 name: alpha1-tanycyte def: "The dorsal-most tanycyte type of the third venticle. These cells projects into the ventromedial or dorsomedial nucleus of the hypothalamus. This type of tanycyte extends its protrusions close to parenchymal neurons without contacting blood vessels. It expresses the glial marker S-100β." [PMID:16344112, PMID:26578855, wikipedia:Tanycyte] comment: In rodents, a1 tanycytes are known to express DARPP-32, GPR50, NA Vimentin, Connexin 43, GLT-1, GLUT1(+) (Goodman and Hajihosseini 2015; Prevot et al., 2018). {xref="PMID:26578855"} subset: human_subset subset: mouse_subset synonym: "DMH tanycyte" RELATED [PMID:29351662] synonym: "VMH tanycyte" RELATED [PMID:29351662] is_a: CL:0002085 ! tanycyte relationship: BFO:0000050 UBERON:0004642 ! part of third ventricle ependyma relationship: RO:0002292 PR:000014419 ! expresses protein S100-B property_value: foaf:depiction http://purl.obolibrary.org/obo/cl/images/fendo-10-00401-g001.jpg {terms:license="https://creativecommons.org/licenses/by/4.0/", xref="doi:10.3389/fendo.2019.00401"} property_value: foaf:depiction http://purl.obolibrary.org/obo/cl/images/fnins-16-1129414-g001.jpg {dc:license="https://creativecommons.org/licenses/by/4.0/", xref="doi:10.3389/fnins.2022.1129414", comment="α1 tanycytes are the most dorsally located subtype, followed by α2 tanycytes, then β1 tanycytes, and finally β2 tanycytes which occupy the ventricular floor. 3V, third ventricle; Arc, arcuate nucleus; DMH, dorsomedial hypothalamic nucleus; VMH, ventromedial hypothalamic nucleus."} property_value: terms:contributor https://orcid.org/0000-0002-0098-8958 property_value: terms:date "2024-08-19T13:06:16Z" xsd:dateTime [Term] id: CL:4042018 name: alpha2-tanycyte def: "Tanycyte of the third ventricle, located immediately ventral to alpha-1 tanycytes. These cells project to the ventromedial and arcuate nuclei of the hypothalamus and express the glial marker S-100β." [PMID:16344112, PMID:26578855, PMID:29351662, wikipedia:Tanycyte] comment: In rodents, this type of tanycyte is more developmentally advanced than alpha1 tanycytes, shows a high neurogenic competence and expresses the following markers DARPP-32, Vimentin, GPR50, Connexin-43, GLT-1, GLUT1(+) (Goodman and Hajihosseini 2015; Prevot et al., 2018) {xref="PMID:26578855"} subset: human_subset subset: mouse_subset synonym: "dmARH tanycyte" RELATED [PMID:29351662] is_a: CL:0002085 ! tanycyte relationship: RO:0002131 UBERON:0001932 ! overlaps arcuate nucleus of hypothalamus relationship: RO:0002292 PR:000014419 ! expresses protein S100-B property_value: foaf:depiction http://purl.obolibrary.org/obo/cl/images/fendo-10-00401-g001.jpg {terms:license="https://creativecommons.org/licenses/by/4.0/", xref="doi:10.3389/fendo.2019.00401"} property_value: foaf:depiction http://purl.obolibrary.org/obo/cl/images/fnins-16-1129414-g001.jpg {dc:license="https://creativecommons.org/licenses/by/4.0/", xref="doi:10.3389/fnins.2022.1129414", comment="α1 tanycytes are the most dorsally located subtype, followed by α2 tanycytes, then β1 tanycytes, and finally β2 tanycytes which occupy the ventricular floor. 3V, third ventricle; Arc, arcuate nucleus; DMH, dorsomedial hypothalamic nucleus; VMH, ventromedial hypothalamic nucleus."} property_value: terms:contributor https://orcid.org/0000-0002-0098-8958 property_value: terms:date "2024-08-19T13:13:20Z" xsd:dateTime [Term] id: CL:4042019 name: beta1-tanycyte def: "A type of tanycyte located in ventral part of the lateral wall of the third ventricle and in the lateral infundibular recess of the brain. This tanycyte has an elongated morphology with multiple microvilli extending into the median eminence. This type of tanycyte expresses FGF receptors 1 and 2, is in contact with GnRH neurons, and is involved in the release of gonadotropin-releasing hormone (GnRH)." [PMID:16344112, PMID:26578855, PMID:29351662, Wikipedia:Tanycyte] subset: human_subset subset: mouse_subset synonym: "vmARH tanycyte" RELATED [PMID:29351662] is_a: CL:0002085 ! tanycyte is_a: CL:1100001 ! secretory epithelial cell relationship: BFO:0000050 UBERON:0006250 ! part of infundibular recess of 3rd ventricle relationship: RO:0002131 UBERON:0002197 ! overlaps median eminence of neurohypophysis relationship: RO:0002215 GO:0032274 ! capable of gonadotropin secretion relationship: RO:0002292 PR:000007479 ! expresses fibroblast growth factor 1 relationship: RO:0002292 PR:000007489 ! expresses fibroblast growth factor 2 property_value: foaf:depiction http://purl.obolibrary.org/obo/cl/images/fendo-10-00401-g001.jpg {terms:license="https://creativecommons.org/licenses/by/4.0/", xref="doi:10.3389/fendo.2019.00401"} property_value: foaf:depiction http://purl.obolibrary.org/obo/cl/images/fnins-16-1129414-g001.jpg {dc:license="https://creativecommons.org/licenses/by/4.0/", xref="doi:10.3389/fnins.2022.1129414", comment="α1 tanycytes are the most dorsally located subtype, followed by α2 tanycytes, then β1 tanycytes, and finally β2 tanycytes which occupy the ventricular floor. 3V, third ventricle; Arc, arcuate nucleus; DMH, dorsomedial hypothalamic nucleus; VMH, ventromedial hypothalamic nucleus."} property_value: terms:contributor https://orcid.org/0000-0002-0098-8958 property_value: terms:date "2024-08-19T13:17:32Z" xsd:dateTime [Term] id: CL:4042020 name: beta2-tanycyte def: "A type of tanycyte located in the floor of third ventricle and the infindibular recess. This tanycyte has an elongated morphology with multiple microvilli extending medially and ventrally to the median eminence, contacting the pial surface and blood vessels. This type of tanycyte expresses FGF receptors 1 and 2, is in contact with GnRH neurons, and is involved in the release of gonadotropin-releasing hormone (GnRH)." [PMID:16344112, PMID:26578855, PMID:29351662, wikipedia:Tanycyte] subset: human_subset subset: mouse_subset synonym: "ME tanycyte" RELATED [PMID:29351662] is_a: CL:0002085 ! tanycyte relationship: BFO:0000050 UBERON:0006250 ! part of infundibular recess of 3rd ventricle relationship: RO:0002131 UBERON:0002197 ! overlaps median eminence of neurohypophysis relationship: RO:0002292 PR:000007479 ! expresses fibroblast growth factor 1 relationship: RO:0002292 PR:000007489 ! expresses fibroblast growth factor 2 property_value: foaf:depiction http://purl.obolibrary.org/obo/cl/images/fendo-10-00401-g001.jpg {terms:license="https://creativecommons.org/licenses/by/4.0/", xref="doi:10.3389/fendo.2019.00401"} property_value: foaf:depiction http://purl.obolibrary.org/obo/cl/images/fnins-16-1129414-g001.jpg {dc:license="https://creativecommons.org/licenses/by/4.0/", xref="doi:10.3389/fnins.2022.1129414", comment="α1 tanycytes are the most dorsally located subtype, followed by α2 tanycytes, then β1 tanycytes, and finally β2 tanycytes which occupy the ventricular floor. 3V, third ventricle; Arc, arcuate nucleus; DMH, dorsomedial hypothalamic nucleus; VMH, ventromedial hypothalamic nucleus."} property_value: terms:contributor https://orcid.org/0000-0002-0098-8958 property_value: terms:date "2024-08-19T13:21:39Z" xsd:dateTime [Term] id: CL:4042021 name: neuronal-restricted precursor def: "A progenitor cell of the central nervous system that differentiates exclusively onto neurons. This progenitor cell is found in a hippocampus subventricular zone, developing cortex and spinal cord of the central nervous system." [PMID:10467245] comment: In vitro cultures of embryonic mouse neural tubes show that neuronal-restricted precursors (NRPs) are derived from multipotent neuroepithelial cells to give rise to neurons. This progression suggests a linear relationship between multipotent progenitors and neuronal-restricted differentiation. (Mayer-Proschel et al., 1997). In the spinal cord of rats, neural-restricted precursor cells give rise cholinergic, GABAergic, glutametergic neurons (Cao and Howard et al., 2002). {xref="PMID:9354325", xref="PMID:12429182"} subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "NRP" RELATED [PMID:12429182] {synonymtypedef="OMO:0003000"} is_a: CL:0000123 ! neuron associated cell (sensu Vertebrata) is_a: CL:0011026 ! progenitor cell relationship: BFO:0000050 UBERON:0001017 ! part of central nervous system property_value: terms:contributor https://orcid.org/0000-0002-0098-8958 property_value: terms:date "2024-09-02T11:42:12Z" xsd:dateTime [Term] id: CL:4042022 name: astrocyte-restricted precursor def: "A progenitor cell of the central nervous system that differentiates exclusively onto astrocytes. This progenitor cell expresses CD44 and S100 calcium-binding protein B." [PMID:15531362, PMID:33052610] comment: In vitro, this progenitor cell can differentiate from glial-restricted precursor cells. {xref="PMID:33052610"} subset: human_subset subset: mouse_subset synonym: "ARP" RELATED [PMID:33052610] {synonymtypedef="OMO:0003000"} synonym: "astrocyte precursor cell" RELATED [PMID:33052610] is_a: CL:0000123 ! neuron associated cell (sensu Vertebrata) is_a: CL:0011026 ! progenitor cell relationship: BFO:0000050 UBERON:0001017 ! part of central nervous system relationship: RO:0002203 CL:0000127 ! develops into astrocyte relationship: RO:0002292 PR:000001307 ! expresses CD44 molecule property_value: terms:contributor https://orcid.org/0000-0002-0098-8958 property_value: terms:date "2024-09-02T11:44:45Z" xsd:dateTime [Term] id: CL:4042023 name: striatal pthlh-expressing interneuron def: "A GABAergic interneuron expressing PTHLH and PVALB that has its soma in a striatum. This GABAergic interneuron type presents a spatial expression gradient of PVALB in the mouse striatum." [PMID:30134177, PMID:37292997] comment: According to spatial transcriptomic data in the human striatum, pthlh-expressing interneurons are one of the most abundant population of interneurons in the striatum (Leonardo D. Garma, et al., 2024). {xref="PMID:37292997"} subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "PTHLH/PVALB cell" RELATED [PMID:37292997] synonym: "PTHLH +/PVALB+ interneuron" RELATED [PMID:37292997] is_a: BFO:0000002 is_a: CL:0002613 ! striatum neuron is_a: CL:0011005 ! GABAergic interneuron relationship: RO:0002292 PR:000013433 ! expresses parathyroid hormone-related protein relationship: RO:0002292 PR:000013502 ! expresses parvalbumin alpha property_value: RO:0002175 NCBITaxon:9606 property_value: terms:contributor https://orcid.org/0000-0002-0098-8958 property_value: terms:date "2024-09-17T10:20:15Z" xsd:dateTime [Term] id: CL:4042024 name: striatal PTHLH MOXD1 expressing interneuron def: "A pthlh-expressing interneuron that expresses MOXD1 and has its soma in a striatum." [PMID:30134177] subset: human_subset subset: mouse_subset is_a: CL:4042023 ! striatal pthlh-expressing interneuron relationship: RO:0002292 PR:000010529 ! expresses DBH-like monooxygenase protein 1 property_value: terms:contributor https://orcid.org/0000-0002-0098-8958 property_value: terms:date "2024-09-17T10:26:57Z" xsd:dateTime [Term] id: CL:4042025 name: substantia nigra dopaminergic neuron def: "A midbrain dopaminergic neuron that has its soma located in a substantia nigra. This dopaminergic neuron type is highly metabolically active and it is involved in the regulation of movement, cognition, motivation and reward. Neurodegeneration of this dopaminergic neuronal type causes loss in fine motor control in Parkinson's Disease." [PMID:32826893, PMID:35308118] subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "SNpc dopaminergic neuron" NARROW [PMID:35308118] is_a: CL:0002614 ! neuron of the substantia nigra is_a: CL:2000097 ! midbrain dopaminergic neuron property_value: RO:0002175 NCBITaxon:9606 property_value: terms:contributor https://orcid.org/0000-0002-0098-8958 property_value: terms:date "2024-09-16T13:09:29Z" xsd:dateTime [Term] id: CL:4042026 name: GABAergic interneuron of the anterior substantia nigra pars reticulata def: "A GABAergic interneuron that has its soma in the anterior section of the substantia nigra pars reticulata. This GABAergic interneuron is characterized by the expression of Six3 and Foxp1 and it develops from Nkx6-2 expressing neuronal progenitors in the ventrolateral midbrain-diencephalon region." [PMID:36148148] subset: human_subset subset: mouse_subset synonym: "aSNpr" RELATED OMO:0003000 [PMID:36148148] is_a: BFO:0000002 is_a: CL:0002614 ! neuron of the substantia nigra relationship: RO:0002292 PR:000007643 ! expresses forkhead box protein P1 relationship: RO:0002292 PR:000013047 ! expresses POU domain, class 6, transcription factor 2 relationship: RO:0002292 PR:000014898 ! expresses homeobox protein SIX3 property_value: terms:contributor https://orcid.org/0000-0002-0098-8958 property_value: terms:date "2024-09-23T13:56:01Z" xsd:dateTime [Term] id: CL:4042027 name: GABAergic interneuron of the posterior substantia nigra pars reticulata def: "A GABAergic interneuron that has its soma in the posterior section of the substantia nigra pars reticulata. This GABAergic interneuron is characterised by the expression of the transcription factors Pax5, Ctip2 and Pou6f2 and it develops from the ventrolateral r1 neuroepithelium expresing NKX61." [PMID:36148148] subset: human_subset subset: mouse_subset synonym: "pSNpr" RELATED [PMID:36148148] is_a: BFO:0000002 is_a: CL:0002614 ! neuron of the substantia nigra relationship: RO:0002292 PR:000001903 ! expresses paired box protein PAX-5 property_value: terms:contributor https://orcid.org/0000-0002-0098-8958 property_value: terms:date "2024-09-23T14:49:11Z" xsd:dateTime [Term] id: CL:4042028 name: immature neuron def: "A neuron in the central nervous system that is not committed to a differentiated fate, has not been newly derived from neurogenesis, and does not integrate into any circuit." [PMID:31096632, PMID:32116519, PMID:37833544] comment: It is hypothesised that immature neurons can be utilised as a neurogenic reserve and that they can be involved in circuit plasticity. {xref="PMID:32116519"} subset: human_subset subset: mouse_subset synonym: "IN" RELATED OMO:0003000 [PMID:32116519] is_a: CL:2000029 ! central nervous system neuron property_value: terms:contributor https://orcid.org/0000-0002-0098-8958 property_value: terms:date "2024-10-10T09:14:45Z" xsd:dateTime [Term] id: CL:4042029 name: cortical immature neuron def: "An immature neuron of a cerebral cortex. This neuron develops prenatally and remains in an immature state throughout the lifespan of the organism." [PMID:37833544] subset: human_subset subset: mouse_subset synonym: "cIN" RELATED OMO:0003000 [PMID:37833544] is_a: CL:0010012 ! cerebral cortex neuron is_a: CL:4042028 ! immature neuron relationship: BFO:0000050 UBERON:0000956 ! part of cerebral cortex property_value: terms:contributor https://orcid.org/0000-0002-0098-8958 property_value: terms:date "2024-10-10T09:14:54Z" xsd:dateTime [Term] id: CL:4042030 name: candelabrum cell def: "A GABAergic interneuron located in the Purkinje layer of the cerebellar cortex. This GABAergic interneuron type has a distinct morphology, it presents a small cell soma near the Purkinje cell layer (PCL), dendrites that extend to the surface of the molecular layer, and beaded axons that make local synapses contacts within the molecular layer. A candelabrum cell is excited by mossy fibers and granule cells but inhibited by Purkinje cells, and it inhibits molecular layer interneurons, which leads to the disinhibition of Purkinje cells." [PMID:35578131] comment: Candelabrum cells are the most abundant interneurons in the Purkinje cell layer and are present in all cerebellar lobules. {xref="PMID:35578131"} subset: human_subset subset: mouse_subset synonym: "candelabrum interneuron" EXACT [PMID:35578131] synonym: "CC" RELATED OMO:0003000 [PMID:35578131] is_a: CL:4072102 ! Purkinje layer interneuron property_value: foaf:depiction Candelabrum:cell.jpg {dc:license="https://creativecommons.org/licenses/by-nc-nd/4.0/", xref="doi:10.3389/fnins.2020.00293"} property_value: terms:contributor https://orcid.org/0000-0002-0098-8958 property_value: terms:date "2024-10-15T11:06:31Z" xsd:dateTime [Term] id: CL:4042031 name: immune oligodendroglia def: "An oligodendrocyte of the central nervous system that exhibits immune properties such as self-presentation and non-self antigen presentation to T cells, phagocytosis of debris, and cytokine and chemokine production. Immune oligodendroglia is immunoreactive during inflammation, neurodegenerative disorders, chronic stress and major depressive disorder." [PMID:30747918, PMID:35301426, PMID:35615276, PMID:35662200] comment: During inflammation, immuno oligodendroglia express MHC II to interact with immune cells in mouse models (Harrington et al., 2023; Madeira et al., 2022). In a mouse model of major depressive disorder and chronic stress, immuno oligodendroglia were associated with prefrontal cortex hypomyelination (Kokkosis et al., 2022). {xref="PMID:35615276", xref="PMID:37057892", xref="PMID:35301426"} subset: human_subset subset: mouse_subset synonym: "Im-OL" RELATED OMO:0003000 [PMID:35301426] synonym: "immune oligodendrocyte" EXACT [PMID:35615276] synonym: "ImOL" RELATED OMO:0003000 [PMID:35615276] synonym: "ImOLG" RELATED OMO:0003000 [PMID:30747918] synonym: "imOLG" RELATED OMO:0003000 [PMID:30747918] is_a: CL:0000128 ! oligodendrocyte relationship: RO:0002215 GO:0002504 ! capable of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II property_value: terms:contributor https://orcid.org/0000-0002-0098-8958 property_value: terms:date "2024-10-11T12:51:17Z" xsd:dateTime [Term] id: CL:4042032 name: PAX6 GABAergic interneuron def: "A transcriptomically distinct GABAergic neuron, located in the cerebral cortex and derived from the CGE, that expresses the transcript PAX6." [https://cellxgene.cziscience.com/e/e4ddac12-f48f-4455-8e8d-c2a48a683437.cxg/, PMID:37824655] comment: The marker set RELN, HCRTR2 can identify the Human cell type PAX6 GABAergic interneuron in the neocortex with a confidence of 0.724125093 (NS-Forest FBeta value). {xref="https://doi.org/10.5281/zenodo.11165918"} subset: human_subset subset: mouse_subset is_a: CL:4023064 ! caudal ganglionic eminence derived interneuron relationship: RO:0002292 PR:000012318 ! expresses paired box protein Pax-6 relationship: RO:0015004 CLM:1000079 ! has characterizing marker set NS forest marker set of PAX6 GABAergic interneuron (Human neocortex). property_value: IAO:0000028 "Pax6 interneuron" xsd:string property_value: RO:0002175 NCBITaxon:9606 property_value: terms:contributor https://orcid.org/0000-0002-0098-8958 property_value: terms:date "2024-10-11T13:25:51Z" xsd:dateTime [Term] id: CL:4042033 name: pro-opiomelanocortin neuron def: "A neuron of the central nervous system that expresses POMC and synthesizes the POMC precursor polypeptide. This neuron type is located in the arcuate nucleus of the hypothalamus and in the nucleus tractus solitarius of the brainstem. The pro-opiomelanocortin neuron is part of the central melanocortin system and it is involved in regulating energy homeostasis, metabolism, and appetite. This neuronal type responds to hormonal signals such as levels of leptin and insulin, and its activation results in the release of α-melanocyte-stimulating hormone (α-MSH), which acts on melanocortin receptors to suppress food intake and increase energy expenditure." [PMID:25870542, PMID:28192062] comment: Pro-opiomelanocortin neurons have a diverse projection pattern. The neurons in the rostral arcuate nucleus project to autonomic areas, caudal arcuate POMC neurons project mainly to hypothalamic areas (Toda et al., 2017). Dysregulation of pro-opiomelanocortin neurons is associated with obesity and metabolic disorders (Quarta et al., 2020). {xref="PMID:28192062", xref="PMID:33633406"} subset: human_subset subset: mouse_subset synonym: "POMC neuron" RELATED [PMID:34002087] synonym: "POMC-expressing neuron" RELATED [PMID:34002087] is_a: CL:0000165 ! neuroendocrine cell relationship: RO:0002292 PR:000013015 ! expresses pro-opiomelanocortin property_value: terms:contributor https://orcid.org/0000-0002-0098-8958 property_value: terms:date "2024-10-15T10:17:41Z" xsd:dateTime [Term] id: CL:4042034 name: CGRP-expressing neuron def: "An interneuron neuron characterized by the expression of calcitonin gene-related peptide (CGRP), a 37-amino acid neuropeptide. This neuron type is involved in nociception and pain modulation by facilitating the transmission of nociceptive signals from peripheral sensory nerve endings to central nervous system structures. This neuron type is found in the dorsal root ganglia (DRG) and trigeminal ganglion, and the spinal cord dorsal horn." [PMID:34061020] subset: human_subset subset: mouse_subset synonym: "Calcitonin gene-related peptide neuron" EXACT [PMID:34061020] synonym: "CGRP-expressing interneuron" RELATED [PMID:34061020] synonym: "CGRP-positive neuron" RELATED [PMID:34061020] is_a: CL:0000526 ! afferent neuron is_a: CL:2000029 ! central nervous system neuron property_value: terms:contributor https://orcid.org/0000-0002-0098-8958 property_value: terms:date "2024-10-30T15:35:08Z" xsd:dateTime [Term] id: CL:4042035 name: molecular layer interneuron def: "A type of cerebellar inhibitory GABAergic interneuron that is located in the molecular layer of the cerebellum. This cell type inhibits Purkinje cells and other molecular layer interneurons. This interneuron plays a crucial role in regulating cerebellar output through feedforward inhibition and is characterized by its fast-spiking properties." [PMID:30742002, PMID:33075461, PMID:34616064, PMID:38692278] subset: human_subset subset: mouse_subset synonym: "MLI" RELATED [PMID:33075461] {RELATED="OMO:0003000"} is_a: CL:4023057 ! cerebellar inhibitory GABAergic interneuron intersection_of: CL:0000099 ! interneuron intersection_of: RO:0002100 UBERON:0002974 ! has soma location molecular layer of cerebellar cortex intersection_of: RO:0002215 GO:0061534 ! capable of gamma-aminobutyric acid secretion, neurotransmission relationship: RO:0002100 UBERON:0002974 ! has soma location molecular layer of cerebellar cortex property_value: terms:contributor https://orcid.org/0000-0002-0098-8958 property_value: terms:date "2024-10-31T15:55:31Z" xsd:dateTime [Term] id: CL:4042036 name: melanin-concentrating hormone neuron def: "A neuron of the central nervous system with its soma primarily located in the lateral hypothalamic area and surrounding regions, including the zona incerta. This neuron type expresses melanin-concentrating hormone and is involved in regulating various physiological processes, including sleep, feeding behavior, and energy homeostasis." [PMID:30284033, PMID:38020069, PMID:39035036] comment: Nearly all melanin-concentrating hormone neurons express the glutamate transporter VGlut2, however a small subset of them expresses the machinery for GABA release and neurotransmission. {xref="PMID:38020069"} subset: human_subset subset: mouse_subset synonym: "MCH neuron" RELATED [PMID:30284033] is_a: CL:2000029 ! central nervous system neuron property_value: terms:contributor https://orcid.org/0000-0002-0098-8958 property_value: terms:date "2024-10-31T16:03:26Z" xsd:dateTime [Term] id: CL:4042037 name: sst GABAergic neuron of the striatum def: "A interneuron of the striatum expressing gamma-aminobutyric acid and somatostatin. This interneuron has a fusiform soma with a diameter between 9 - 25 µm, it has a long axon up to the length of 1mm. This neuron type displays a low threshold Ca2+ spike (LTS), a high input resistance, and the expression of long-lasting plateau potentials following depolarization from rest." [PMID:30131490, PMID:30467465, PMID:33742131] comment: Some striatal SST GABAergic neurons can co-release glutamate and generate excitation-inhibition responses in postsynaptic neurons. This interneuron type has the least dense dendritic branches in the striatum. In the dorsomedial striatum these neurons regulate the activity of striatal projection neurons. {xref="PMID:30467465", xref="PMID:33742131"} subset: human_subset subset: mouse_subset synonym: "SOM cell" BROAD [PMID:30131490] synonym: "striatal SST+ IN" RELATED [PMID:33742131] is_a: BFO:0000002 is_a: CL:0000617 ! GABAergic neuron is_a: CL:0002613 ! striatum neuron relationship: RO:0002292 PR:000015665 ! expresses somatostatin property_value: terms:contributor https://orcid.org/0000-0002-0098-8958 property_value: terms:date "2024-11-27T18:33:46Z" xsd:dateTime [Term] id: CL:4042038 name: rostral primary motorneuron def: "A type of primary motor neuron situated in the rostral region of the spinal cord. RoP neurons extend their axons to innervate the ventral trunk musculature." [PMID:35431796, PMID:3746410] synonym: "RoP" RELATED OMO:0003000 [PMID:3746410] is_a: CL:0000533 ! primary motor neuron (sensu Teleostei) property_value: terms:contributor https://orcid.org/0000-0002-0098-8958 property_value: terms:date "2024-11-13T13:42:01Z" xsd:dateTime [Term] id: CL:4042039 name: caudal ganglionic eminence derived neuron def: "A neuron of the central nervous system that develops from a caudal ganglionic eminence." [https://www.ncbi.nlm.nih.gov/books/NBK98190/, PMID:12593982, PMID:12637172, PMID:20130169] comment: Neurons derived from the caudal ganglionic eminence consist mostly of neurons populating the cortical layers of the brain and some subcortical areas such as the globus pallidus, the striatus and the hippocampus. Amongst neurons derived from the caudal ganglionic eminence there are cortical GABAergic neurons such as Pax6, Lamp5, VIP, sncg, GABAergic; in the hippocampus, mossy fibers, pyramidal neurons, granule neurons and interneurons; in the striatum and globus pallidus, medium spiny projection neurons. {xref="https://www.ncbi.nlm.nih.gov/books/NBK98190/", xref="PMID:12637172", xref="PMID:12593982", xref="PMID:20130169"} subset: human_subset subset: mouse_subset is_a: BFO:0000002 is_a: CL:2000029 ! central nervous system neuron relationship: RO:0002202 UBERON:0004026 ! develops from caudal ganglionic eminence property_value: terms:contributor https://orcid.org/0000-0002-0098-8958 property_value: terms:date "2024-11-14T11:27:25Z" xsd:dateTime [Term] id: CL:4042040 name: glutamatergic neuron of the basal ganglia def: "A glutametergic neuron with its soma located in a basal ganglia. This neuron type is involved in motor control, decision making and learning." [DOI:10.1016/j.jocn.2021.05.056, PMID:11307040, PMID:16276355] comment: The glutametergic neurons in the basal ganglia are part of a series of different circuits such as the corticolstriatal circuit, which is involved in regulating voluntary movements. The subthalamic nucleus circuit, which is involved in modulating the output of the basal ganglia, particularly in controlling movement initiation and inhibition. The thalamocortical loop, which is involved in refining motor movements and integrating sensory information with motor commanding. {xref="PMID:30498197", xref="PMID:22498715", xref="PMID:33785138"} subset: human_reference_atlas subset: human_subset subset: mouse_subset is_a: CL:0000679 ! glutamatergic neuron is_a: CL:2000029 ! central nervous system neuron relationship: RO:0002100 UBERON:0002420 ! has soma location basal ganglion property_value: RO:0002175 NCBITaxon:9606 property_value: terms:contributor https://orcid.org/0000-0002-0098-8958 property_value: terms:date "2024-11-18T13:37:58Z" xsd:dateTime [Term] id: CL:4042041 name: middle primary motoneuron def: "A type of primary motor neuron located in the middle region of the spinal cord. This primary motor neuron type is characterized by their distinct axonal pathways that innervate the middle trunk muscles." [PMID:35431796, PMID:3746410] synonym: "MiP" RELATED OMO:0003000 [PMID:3746410] xref: ZFA:0005179 is_a: CL:0000533 ! primary motor neuron (sensu Teleostei) property_value: terms:contributor https://orcid.org/0000-0002-0098-8958 property_value: terms:date "2024-11-13T13:39:28Z" xsd:dateTime [Term] id: CL:4047001 name: cycling stromal cell def: "A(n) stromal cell that is cycling." [PMID:34497389] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "proliferating stromal cell" EXACT [PMID:34497389] is_a: CL:0000499 ! stromal cell intersection_of: CL:0000499 ! stromal cell intersection_of: RO:0000056 GO:0022402 ! participates in cell cycle process intersection_of: RO:0000086 PATO:0002354 ! has quality active relationship: RO:0000056 GO:0022402 ! participates in cell cycle process relationship: RO:0000086 PATO:0002354 ! has quality active [Term] id: CL:4047002 name: cycling glial cell def: "A(n) glial cell that is cycling." [PMID:34497389] subset: human_subset subset: mouse_subset synonym: "proliferating glial cell" EXACT [PMID:34497389] is_a: CL:0000125 ! glial cell intersection_of: CL:0000125 ! glial cell intersection_of: RO:0000056 GO:0022402 ! participates in cell cycle process intersection_of: RO:0000086 PATO:0002354 ! has quality active relationship: RO:0000056 GO:0022402 ! participates in cell cycle process relationship: RO:0000086 PATO:0002354 ! has quality active [Term] id: CL:4047003 name: cycling plasma cell def: "A(n) plasma cell that is cycling." [PMID:34497389] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "proliferating plasma cell" EXACT [PMID:34497389] is_a: CL:0000786 ! plasma cell intersection_of: CL:0000786 ! plasma cell intersection_of: RO:0000056 GO:0022402 ! participates in cell cycle process intersection_of: RO:0000086 PATO:0002354 ! has quality active relationship: RO:0000056 GO:0022402 ! participates in cell cycle process relationship: RO:0000086 PATO:0002354 ! has quality active [Term] id: CL:4047004 name: cycling type EC enteroendocrine cell def: "A(n) type EC enteroendocrine cell that is cycling." [PMID:34497389] subset: human_subset subset: mouse_subset synonym: "proliferating type EC enteroendocrine cell" EXACT [PMID:34497389] is_a: CL:0000577 ! type EC enteroendocrine cell intersection_of: CL:0000577 ! type EC enteroendocrine cell intersection_of: RO:0000056 GO:0022402 ! participates in cell cycle process intersection_of: RO:0000086 PATO:0002354 ! has quality active relationship: RO:0000056 GO:0022402 ! participates in cell cycle process relationship: RO:0000086 PATO:0002354 ! has quality active [Term] id: CL:4047005 name: cycling neuroblast (sensu Vertebrata) def: "A(n) neuroblast (sensu Vertebrata) that is cycling." [PMID:34497389] subset: human_subset subset: mouse_subset synonym: "proliferating neuroblast (sensu Vertebrata)" EXACT [PMID:34497389] is_a: CL:0000031 ! neuroblast (sensu Vertebrata) intersection_of: CL:0000031 ! neuroblast (sensu Vertebrata) intersection_of: RO:0000056 GO:0022402 ! participates in cell cycle process intersection_of: RO:0000086 PATO:0002354 ! has quality active relationship: RO:0000056 GO:0022402 ! participates in cell cycle process relationship: RO:0000086 PATO:0002354 ! has quality active [Term] id: CL:4047006 name: fetal artery endothelial cell def: "An endothelial cell that lines an artery in the fetal circulatory system." [PMID:34497389] subset: human_subset subset: mouse_subset synonym: "endothelial cell of fetal artery" EXACT [PMID:34497389] synonym: "fetal arterial EC" EXACT [PMID:34497389] synonym: "fetal artery EC" EXACT [PMID:34497389] is_a: CL:1000413 ! endothelial cell of artery property_value: terms:contributor https://orcid.org/0009-0005-7919-4905 property_value: terms:date "2024-08-16T13:52:25Z" xsd:dateTime [Term] id: CL:4047007 name: immature pericyte def: "A pericyte that is in an early stage of development, found in newly forming or remodeling blood vessels. An immature pericyte is characterized by it's mesenchymal stem cell-like properties and high proliferative capacity, which allows it to differentiate into various types of pericytes and contribute to the structural and functional maturation of the vasculature. Immature pericytes are stellate in new vessels and elongated with less protrusions in remodeling vessels." [PMID:21839917, PMID:28564607, PMID:32466671, PMID:34497389, PMID:36685855] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "immature PCs" RELATED OMO:0003000 [PMID:28564607] synonym: "imPCs" RELATED OMO:0003000 [PMID:28564607] is_a: CL:0000669 ! pericyte property_value: terms:contributor https://orcid.org/0009-0005-7919-4905 property_value: terms:date "2024-08-19T11:32:32Z" xsd:dateTime [Term] id: CL:4047011 name: fetal vein endothelial cell def: "An endothelial cell that lines the veins in the fetal circulatory system." [doi:10.1101/2021.04.07.438755] subset: human_subset subset: mouse_subset synonym: "fetal vein EC" RELATED OMO:0003000 [doi:10.1101/2021.04.07.438755] synonym: "fetal venous EC" RELATED OMO:0003000 [doi:10.1101/2021.04.07.438755] synonym: "fetal venous endothelial cell" EXACT [doi:10.1101/2021.04.07.438755] is_a: CL:0002543 ! vein endothelial cell property_value: terms:contributor https://orcid.org/0009-0005-7919-4905 property_value: terms:date "2024-09-05T15:45:32Z" xsd:dateTime [Term] id: CL:4047012 name: angiogenic pericyte def: "A specialized pericyte that actively participates in the formation of new blood vessels during angiogenesis by undergoing phenotypic changes, increasing proliferation, and interacting closely with endothelial cells." [PMID:24853910, PMID:34497389] subset: cellxgene_subset subset: human_subset subset: mouse_subset is_a: CL:0000669 ! pericyte property_value: terms:contributor https://orcid.org/0009-0005-7919-4905 property_value: terms:date "2024-09-06T08:41:39Z" xsd:dateTime [Term] id: CL:4047017 name: transit amplifying cell of gut def: "A transit amplifying cell of the gut epithelium, located in the wall of the intestinal crypt, just above intestinal stem cells from which they derive. These are rapidly dividing cells, capable of multiple rounds of division before differentiating into the various cell types of the gut epithelium (enterocyte, goblet, eneterodendocrine, paneth cells)." [PMID:20683682, PMID:33195268, PMID:34497389] subset: human_subset subset: mouse_subset synonym: "TA cell" RELATED [PMID:20683682] synonym: "transit-amplifying cell" BROAD [PMID:24813615] is_a: CL:0002563 ! intestinal epithelial cell is_a: CL:0009010 ! transit amplifying cell intersection_of: CL:0009010 ! transit amplifying cell intersection_of: BFO:0000050 UBERON:0013740 ! part of wall of crypt of Lieberkuhn relationship: BFO:0000050 UBERON:0013740 ! part of wall of crypt of Lieberkuhn relationship: RO:0002207 CL:0002250 ! directly develops from intestinal crypt stem cell property_value: terms:contributor https://orcid.org/0009-0005-7919-4905 property_value: terms:date "2024-09-24T10:48:47Z" xsd:dateTime [Term] id: CL:4047018 name: early colonocyte def: "An enterocyte that is part of the colon, in the early stages of differentiation, located in the intestinal crypt-villus axis." [PMID:28049136, PMID:36060223] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "early enterocyte of colon" EXACT [doi:10.1101/2021.01.13.426602] is_a: CL:1000347 ! colonocyte is_a: CL:4047019 ! early enterocyte intersection_of: CL:4047019 ! early enterocyte intersection_of: BFO:0000050 UBERON:0000397 ! part of colonic epithelium property_value: terms:contributor https://orcid.org/0009-0005-7919-4905 property_value: terms:date "2024-09-24T11:50:13Z" xsd:dateTime [Term] id: CL:4047019 name: early enterocyte def: "An enterocyte in the early stages of development, located above the transit-amplifying cell zone in the intestinal crypt-villus axis." [PMID:20683682, PMID:35235783] subset: human_subset subset: mouse_subset is_a: CL:0000584 ! enterocyte intersection_of: CL:0000584 ! enterocyte intersection_of: BFO:0000050 UBERON:0013740 ! part of wall of crypt of Lieberkuhn relationship: BFO:0000050 UBERON:0013740 ! part of wall of crypt of Lieberkuhn property_value: terms:contributor https://orcid.org/0009-0005-7919-4905 property_value: terms:date "2024-09-24T12:11:09Z" xsd:dateTime [Term] id: CL:4047023 name: intestinal lamina propria fibroblast def: "A fibroblast located in the lamina propria of the intestinal mucosa. This cell expresses PDGFRα and CD81 and is negative for α-smooth muscle actin (α-SMA). This cell is predominantly located in the small intestine adjacent to myofibroblasts surrounding the crypts. It is capable of synthesizing extracellular matrix components and structural proteins such as collagen and elastin." [PMID:21252048, PMID:36032088] subset: human_subset subset: mouse_subset synonym: "S1 fibroblast" RELATED [PMID:30270042] is_a: CL:0000057 ! fibroblast is_a: CL:0000151 ! secretory cell intersection_of: CL:0000057 ! fibroblast intersection_of: BFO:0000050 UBERON:0004780 ! part of gastrointestinal system lamina propria intersection_of: RO:0002215 GO:0070278 ! capable of extracellular matrix constituent secretion relationship: BFO:0000050 UBERON:0004780 ! part of gastrointestinal system lamina propria relationship: RO:0002215 GO:0070278 ! capable of extracellular matrix constituent secretion property_value: terms:contributor https://orcid.org/0009-0005-7919-4905 property_value: terms:date "2024-09-24T15:45:18Z" xsd:dateTime [Term] id: CL:4047025 name: type G cell of stomach def: "Any type G enteroendocrine cell that is part of some epithelium of stomach." [FBC:Autogenerated] subset: human_subset subset: mouse_subset is_a: CL:0000508 ! type G enteroendocrine cell is_a: CL:1000222 ! stomach neuroendocrine cell intersection_of: CL:0000508 ! type G enteroendocrine cell intersection_of: BFO:0000050 UBERON:0001276 ! part of epithelium of stomach property_value: terms:contributor https://orcid.org/0009-0005-7919-4905 property_value: terms:date "2024-10-24T10:43:22Z" xsd:dateTime [Term] id: CL:4047029 name: post-arteriole capillary cell def: "An endothelial cell forming the walls of capillaries immediately downstream from arterioles, facilitating the exchange of substances between blood and interstitial fluid. This cell is characterized by a small diameter and may be continuous, fenestrated, or sinusoidal, depending on their location and function. This cell plays a crucial role in tissue oxygenation, nutrient delivery, and maintaining homeostasis within the microvascular network." [PMID:17893694, PMID:35406678] subset: human_subset subset: mouse_subset is_a: CL:0002144 ! capillary endothelial cell property_value: terms:contributor https://orcid.org/0009-0005-7919-4905 property_value: terms:date "2024-11-07T12:50:06Z" xsd:dateTime [Term] id: CL:4047030 name: pre-venule capillary cell def: "A specialized endothelial cell located in the transition zone between capillaries and small venules in the microvascular system. It exhibits characteristics of both capillary and venous cells, expressing markers from both types. This cell plays a role in regulating blood flow and substance exchange between blood and tissues." [DOI:10.1038/s41467-022-33324-7, PMID:23620236] subset: human_subset subset: mouse_subset synonym: "Cap-Venous endothelial cell" EXACT [DOI:10.1038/s41467-022-33324-7] is_a: CL:0002144 ! capillary endothelial cell property_value: terms:contributor https://orcid.org/0009-0005-7919-4905 property_value: terms:date "2024-11-07T13:22:16Z" xsd:dateTime [Term] id: CL:4047032 name: secretory pericyte def: "A specialized pericyte located within the basement membrane of a blood capillary. This cell is characterized by its ability to produce and release a variety of bioactive molecules, collectively known as the pericyte secretome, including cytokines and regulators of angiogenesis." [DOI:10.3389/fncel.2019.00282] subset: human_subset subset: mouse_subset is_a: CL:0000151 ! secretory cell is_a: CL:0000669 ! pericyte relationship: RO:0002215 GO:0001816 ! capable of cytokine production relationship: RO:0002215 GO:0045765 ! capable of regulation of angiogenesis property_value: terms:contributor https://orcid.org/0009-0005-7919-4905 property_value: terms:date "2024-11-07T15:36:16Z" xsd:dateTime [Term] id: CL:4047034 name: smooth muscle cell of stomach def: "A smooth muscle cell that is part of the muscularis externa of the stomach wall. It is characterized by its fusiform shape, involuntary control, and ability to generate slow, sustained contractions. This cell is organized in distinct layers and is essential for gastric motility and digestion." [PMID:21443757, PMID:33630273] subset: human_subset subset: mouse_subset is_a: CL:0000192 ! smooth muscle cell intersection_of: CL:0000192 ! smooth muscle cell intersection_of: BFO:0000050 UBERON:0008856 ! part of stomach muscularis externa relationship: BFO:0000050 UBERON:0008856 ! part of stomach muscularis externa property_value: terms:contributor https://orcid.org/0009-0005-7919-4905 property_value: terms:date "2024-12-05T11:10:18Z" xsd:dateTime [Term] id: CL:4047035 name: stomach smooth muscle outer longitudinal layer cell def: "A specialized smooth muscle cell located in the outermost layer of the muscularis externa of the stomach wall. This cell is arranged longitudinally along the stomach's axis and is responsible for the contractions that facilitate food movement toward the pylorus." [PMID:21443757, PMID:33630273] subset: human_subset subset: mouse_subset is_a: CL:4047034 ! smooth muscle cell of stomach property_value: terms:contributor https://orcid.org/0009-0005-7919-4905 property_value: terms:date "2024-12-05T16:13:49Z" xsd:dateTime [Term] id: CL:4047036 name: stomach smooth muscle circular layer cell def: "A smooth muscle cell located in the middle layer of the muscularis externa of the stomach wall. This cell is arranged concentrically with the stomach's longitudinal axis, forming a continuous sheet of contractile tissue. It is fusiform in shape, containing actin and myosin filaments that enable contraction without striations. This cell contributes to the mechanical digestion and movement of food within the stomach through coordinated contractions, and plays a role in forming the pyloric sphincter in the pyloric region." [PMID:11146428, PMID:32424507] subset: human_subset subset: mouse_subset is_a: CL:4047034 ! smooth muscle cell of stomach intersection_of: CL:0000192 ! smooth muscle cell intersection_of: BFO:0000050 UBERON:0008857 ! part of stomach smooth muscle circular layer relationship: BFO:0000050 UBERON:0008857 ! part of stomach smooth muscle circular layer property_value: terms:contributor https://orcid.org/0009-0005-7919-4905 property_value: terms:date "2024-12-09T10:40:58Z" xsd:dateTime [Term] id: CL:4047037 name: stomach smooth muscle inner oblique layer cell def: "A smooth muscle cell found in the innermost layer of the muscularis externa of the stomach wall. This cell forms a unique layer of smooth muscle fibers oriented obliquely to the stomach's longitudinal axis. It is responsible for aiding in the mixing and churning of gastric contents, contributing to mechanical digestion within the stomach." [PMID:29493959] subset: human_subset subset: mouse_subset synonym: "stomach smooth muscle oblique layer cell" EXACT [] is_a: CL:4047034 ! smooth muscle cell of stomach intersection_of: CL:0000192 ! smooth muscle cell intersection_of: BFO:0000050 UBERON:0008862 ! part of stomach smooth muscle inner oblique layer relationship: BFO:0000050 UBERON:0008862 ! part of stomach smooth muscle inner oblique layer property_value: terms:contributor https://orcid.org/0009-0005-7919-4905 property_value: terms:date "2024-12-09T10:53:19Z" xsd:dateTime [Term] id: CL:4047038 name: dogiel type I neuron def: "A multipolar neuron in the myenteric plexus of the gastrointestinal tract, characterized by a small to medium-sized cell body and multiple short dendrites. This neuron exhibits fast excitatory postsynaptic potentials and can be classified into stubby, spiny and hairy subtypes based on dendritic morphology. (Brehmer, 2021)" [DOI:10.1038/s41575-020-0271-2, DOI:10.1038/s41575-021-00561-y, PMID:32152479, PMID:34170401] subset: human_subset subset: mouse_subset is_a: CL:0000104 ! multipolar neuron is_a: CL:0007011 ! enteric neuron relationship: RO:0002100 UBERON:0002439 ! has soma location myenteric nerve plexus property_value: terms:contributor https://orcid.org/0009-0005-7919-4905 property_value: terms:date "2024-12-16T13:42:04Z" xsd:dateTime [Term] id: CL:4047040 name: smooth muscle circular layer cell def: "A smooth muscle cell that is found in the inner muscular layer of hollow organs. It is characterized by its spiral/helical arrangement around organ lumens. This cell is crucial for peristaltic movements in organs." [PMID:18221249, PMID:27445346] subset: human_subset subset: mouse_subset is_a: CL:0000192 ! smooth muscle cell relationship: BFO:0000050 UBERON:0012368 ! part of circular muscle layer of muscular coat property_value: terms:contributor https://orcid.org/0009-0005-7919-4905 property_value: terms:date "2025-01-06T15:40:21Z" xsd:dateTime [Term] id: CL:4047042 name: type 1 myenteric plexus glia def: "An enteric glial cell located within the myenteric ganglia of the gastrointestinal tract. This cell has a small somata and has very short, irregularly branched processes that surround neuron cell bodies, giving it a protoplasmic-like appearance. It plays crucial roles in modulating myenteric neuron activity, regulating oxidative stress, and influencing neuroinflammation and neurogenesis." [PMID:19906678, PMID:21865647, PMID:26964064, PMID:28066889, PMID:33731961] subset: human_subset subset: mouse_subset synonym: "type 1 MP" RELATED OMO:0003000 [PMID:33731961] is_a: CL:4040002 ! enteroglial cell relationship: BFO:0000050 UBERON:0002439 ! part of myenteric nerve plexus property_value: terms:contributor https://orcid.org/0009-0005-7919-4905 property_value: terms:date "2025-02-10T16:49:55Z" xsd:dateTime [Term] id: CL:4047043 name: type 1 submucosal plexus glia def: "An enteric glial cell that is associated with neuron cell bodies within submucosal ganglia of the gastrointestinal tract. This cell is located in the submucosa, a layer of connective tissue beneath the intestinal mucosa. This cell plays a role in modulating secretomotor neuron activity and contributes to the regulation of digestive fluid secretion and absorption." [DOI:10.3389/fncel.2023.1170309, PMID:28487635, PMID:33731961] subset: human_subset subset: mouse_subset synonym: "type I SMP" RELATED OMO:0003000 [PMID:33731961] is_a: CL:4040002 ! enteroglial cell relationship: BFO:0000050 UBERON:0009566 ! part of intestinal submucosa property_value: terms:contributor https://orcid.org/0009-0005-7919-4905 property_value: terms:date "2025-02-10T17:02:28Z" xsd:dateTime [Term] id: CL:4047044 name: type 2 interganglionic glia def: "An enteric glial cell that has an elongated, fibrous morphology with long processes that run parallel to nerve fibers connecting enteric myenteric ganglia. This cell is located in the interganglionic fiber tracts of the enteric nervous system." [DOI:10.1002/glia.22876, PMID:33731961, PMID:35111752] subset: human_subset subset: mouse_subset synonym: "type II enteric glia" EXACT [PMID:35111752] is_a: CL:4040002 ! enteroglial cell relationship: BFO:0000050 UBERON:0000429 ! part of enteric plexus property_value: terms:contributor https://orcid.org/0009-0005-7919-4905 property_value: terms:date "2025-02-11T12:28:37Z" xsd:dateTime [Term] id: CL:4047045 name: type 3 mucosal glia def: "An enteric glial cell located in the lamina propria of the intestinal mucosa. This cell plays important roles in maintaining gut barrier function, regulating intestinal homeostasis, and mediating interactions between the enteric nervous system and the immune system." [PMID:25161129, PMID:33731961, PMID:37153631, PMID:38957473] subset: human_subset subset: mouse_subset is_a: CL:4040002 ! enteroglial cell relationship: BFO:0000050 UBERON:0000030 ! part of lamina propria property_value: terms:contributor https://orcid.org/0009-0005-7919-4905 property_value: terms:date "2025-02-11T12:39:11Z" xsd:dateTime [Term] id: CL:4047047 name: type I enteric glial cell def: "An enteric glial cell located within the ganglia of the enteric nervous system. This cell is characterized by it’s small somata and short, irregularly branched processes that surround neuronal cell bodies in the myenteric and submucosal ganglia. This cell plays important roles in modulating neuronal activity and neurogenesis in the gastrointestinal tract." [DOI:10.1016/j.celrep.2023.112194, PMID:29927320, PMID:33731961, PMID:35111752] subset: human_subset subset: mouse_subset synonym: "intraganglionic glia" EXACT [PMID:33731961] synonym: "type 1 enteric glia" EXACT [] synonym: "type I enteric glia" EXACT [PMID:35111752] is_a: CL:4040002 ! enteroglial cell relationship: BFO:0000050 UBERON:0001809 ! part of enteric ganglion property_value: terms:contributor https://orcid.org/0009-0005-7919-4905 property_value: terms:date "2025-02-11T13:35:14Z" xsd:dateTime [Term] id: CL:4047048 name: type 4 muscularis propria glia def: "An enteric glial cell characterized by a small central soma that extends long, thin, bipolar projections. This cell is primarily located along small nerve fibers within the muscle layers of the gastrointestinal tract and is known for its unbranching processes that closely follow these nerve fibers in the muscularis." [PMID:33731961, PMID:34401661] subset: human_subset subset: mouse_subset synonym: "intramuscular glia" RELATED [PMID:34401661] is_a: CL:4040002 ! enteroglial cell relationship: BFO:0000050 UBERON:0006660 ! part of muscular coat property_value: terms:contributor https://orcid.org/0009-0005-7919-4905 property_value: terms:date "2025-02-18T11:14:25Z" xsd:dateTime [Term] id: CL:4047051 name: small intestine BEST4+ enterocyte def: "An enterocyte of the human small intestine expressing bestrophin-4 (BEST4) calcium-activated ion channels. These enterocytes have a disinctive transcriptomic profile and are scattered through the small intestine epithelium." [PMID:24223998, PMID:34497389] subset: human_subset is_a: CL:1000334 ! enterocyte of epithelium of small intestine is_a: CL:4030026 ! BEST4+ enterocyte intersection_of: CL:0000584 ! enterocyte intersection_of: BFO:0000050 UBERON:0001902 ! part of epithelium of small intestine intersection_of: RO:0002292 PR:Q8NFU0 ! expresses bestrophin-4 (human) property_value: terms:contributor https://orcid.org/0009-0005-7919-4905 property_value: terms:date "2024-07-25T13:05:50Z" xsd:dateTime [Term] id: CL:4047052 name: BEST4+ colonocyte def: "An enterocyte of the human colon expressing bestrophin-4 (BEST4) calcium-activated ion channels. These cells have a distinct transcriptomic profile compared to other enterocytes and are scattered through the colon epithelium." [PMID:24223998, PMID:34497389] subset: cellxgene_subset subset: human_subset is_a: CL:1000347 ! colonocyte is_a: CL:4030026 ! BEST4+ enterocyte intersection_of: CL:1000347 ! colonocyte intersection_of: RO:0002292 PR:Q8NFU0 ! expresses bestrophin-4 (human) property_value: terms:contributor https://orcid.org/0009-0005-7919-4905 property_value: terms:date "2024-07-25T13:21:19Z" xsd:dateTime [Term] id: CL:4047053 name: TREM2-positive macrophage def: "A macrophage characterized by high expression of Triggering Receptor Expressed on Myeloid cells 2 (TREM2), found in various tissues including the liver, adipose tissue, bone, gut (Colonna, 2023), and tumor microenvironments, where it is associated with immunosuppressive and anti-inflammatory activity (Colmenares, 2024; Khantakova, 2022). This cell exhibits a distinct gene expression profile in the tumor microenvironment, including overexpression of complement system genes (C1QA, C1QB, C1QC, C3), and SPP1 in both mice and humans (Xiong, 2020; Khantakova, 2022). It is involved in phagocytosis, tissue repair, and modulation of immune responses (Coeho, 2021)." [PMID:33033253, PMID:33628208, PMID:35746551, PMID:36750615, PMID:39369473] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "TREM-2 + resident macrophage" NARROW [PMID:39369473] synonym: "TREM2+ macrophage" NARROW [PMID:35746551] is_a: CL:0000235 ! macrophage intersection_of: CL:0000235 ! macrophage intersection_of: RO:0002292 PR:000016626 ! expresses triggering receptor expressed on myeloid cells 2 relationship: RO:0002292 PR:000016626 ! expresses triggering receptor expressed on myeloid cells 2 property_value: terms:contributor https://orcid.org/0009-0005-7919-4905 property_value: terms:date "2025-03-17T17:20:08Z" xsd:dateTime [Term] id: CL:4047054 name: migratory dendritic cell def: "A dendritic cell capable of capturing antigens in peripheral tissues and migrating through blood or lymphatic vessels to secondary lymphoid organs, where it presents processed antigens to T cells. It expresses MHC class II molecules and lacks lineage markers associated with other leukocyte populations, distinguishing it as a member of the dendritic cell lineage. This cell plays a pivotal role in initiating and regulating adaptive immune responses by linking peripheral antigen capture with T cell activation in lymphoid tissues." [PMID:28845904, PMID:33681216, PMID:34302064] subset: cellxgene_subset subset: human_subset subset: mouse_subset is_a: CL:0000451 ! dendritic cell relationship: RO:0002215 GO:0002407 ! capable of dendritic cell chemotaxis relationship: RO:0002215 GO:0002468 ! capable of dendritic cell antigen processing and presentation property_value: terms:contributor https://orcid.org/0009-0005-7919-4905 property_value: terms:date "2025-03-17T17:37:37Z" xsd:dateTime [Term] id: CL:4047056 name: large mucus secreting cholangiocyte def: "A columnar, mucin-producing cholangiocyte that lines large bile ducts, including the hilar bile duct, right and left hepatic bile ducts, and large intrahepatic bile ducts. This cell expresses phosphorylated STAT3 and TFF-3 in humans and mice." [doi:10.1002/hep.25595, doi:10.1152/ajpgi.00227.2012, PMID:15579435, PMID:26273695, PMID:28261592] subset: human_subset subset: mouse_subset synonym: "mucin-secreting cholangiocyte" NARROW [doi:10.1152/ajpgi.00227.2012] is_a: CL:0000319 ! mucus secreting cell is_a: CL:1000488 ! cholangiocyte is_a: CL:1100001 ! secretory epithelial cell property_value: terms:contributor https://orcid.org/0009-0005-7919-4905 property_value: terms:date "2025-03-20T14:21:41Z" xsd:dateTime [Term] id: CL:4047060 name: BAG3-positive monocyte def: "A circulating mononuclear phagocyte characterized by the expression of BCL-2-associated athanogene 3 (BAG3) protein, a co-chaperone involved in protein quality control and anti-apoptotic processes. (Fontanella, 2009). It undergoes cellular stress during the differentiation into M2 macrophages and is linked to poor survival rates in multiple cancer types. (Park, 2023)" [doi:10.21203/rs.3.rs-3229780/v1, PMID:20018251] subset: human_subset subset: mouse_subset synonym: "BAG3+ monocyte" EXACT [doi:10.21203/rs.3.rs-3229780/v1] is_a: CL:0000576 ! monocyte intersection_of: CL:0000576 ! monocyte intersection_of: RO:0002292 PR:000004621 ! expresses BAG family molecular chaperone regulator 3 relationship: RO:0002292 PR:000004621 ! expresses BAG family molecular chaperone regulator 3 property_value: terms:contributor https://orcid.org/0009-0005-7919-4905 property_value: terms:date "2025-05-06T14:41:24Z" xsd:dateTime [Term] id: CL:4047101 name: liver-resident natural killer cell def: "A natural killer cell resident to the liver, located in the hepatic sinusoids. In humans this cell type is distinguished from circulating natural killer cells by CD49a or CD69 gene expression. Liver-resident natural killer cells have also been shown to express CCR5, EOMES, KLRB1, GZMK, and CXCR6 in humans." [PMID:26330348, PMID:26639736, PMID:27798170, PMID:31114585, PMID:32351704, PMID:34230995, PMID:35865550] comment: Liver-resident natural killer cells play a crucial role in modulating the immune response during inflammation by balancing cytotoxic activity and cytokine production, thereby contributing to the maintenance of liver homeostasis and protection against excessive tissue damage. {xref="PMID:34230995"} subset: human_subset subset: mouse_subset synonym: "he-NK" EXACT [PMID:31114585] synonym: "hepatic natural killer cells" EXACT [doi:10.3389/fimmu.2019.00946] synonym: "hepatic NK" EXACT [doi:10.3389/fimmu.2019.00946] synonym: "intrahepatic NK" EXACT [PMID:33828559] synonym: "liver NK cell" EXACT [PMID:26639736] synonym: "liver resident natural killer cell" EXACT [PMID:26330348] synonym: "liver-specific natural killer cell" EXACT [] synonym: "lr-NK" EXACT [PMID:35726345] is_a: CL:0000623 ! natural killer cell intersection_of: CL:0000623 ! natural killer cell intersection_of: RO:0001025 UBERON:0001281 ! located in hepatic sinusoid relationship: RO:0001025 UBERON:0001281 ! located in hepatic sinusoid property_value: terms:contributor "https://orcid.org/0000-0001-8134-3037" xsd:string property_value: terms:contributor https://orcid.org/0009-0005-7919-4905 property_value: terms:date "2024-07-29T13:43:11Z" xsd:dateTime [Term] id: CL:4052001 name: multiciliated ependymal cell def: "An ependymal cell that lines the lateral, third, and fourth ventricles of the brain. The cell is characterized by multiple motile cilia on its apical surface, which beats in a coordinated manner to facilitate the movement of cerebrospinal fluid (CSF), contributing to brain homeostasis." [PMID:25045600, PMID:28067220, PMID:37008045] comment: multiciliated ependymal cell, with an average of 16 motile cilia per cell, exhibits two types of planar cell polarity (PCP): rotational polarity, with unidirectional cilia orientation, and translational polarity, with asymmetric cilia positioning in the apical area. This location-specific PCP varies across the ventricular wall, aligning with the direction of CSF flow. These cells are interconnected by adherens and gap junctions, which support intercellular communication and maintain the structural integrity of the ependymal layer. Unlike some other cell types, these cells lack tight junctions. {xref="PMID:25045600", xref="PMID:27311928"} subset: human_subset subset: mouse_subset synonym: "E1" RELATED OMO:0003000 [PMID:28067220, PMID:37008045] synonym: "multiciliated ependymal cells" BROAD [PMID:25045600] is_a: CL:0000065 ! ependymal cell is_a: CL:0005012 ! multiciliated epithelial cell intersection_of: CL:0000075 ! columnar/cuboidal epithelial cell intersection_of: BFO:0000050 UBERON:0004670 ! part of ependyma intersection_of: BFO:0000051 GO:0031514 ! has part motile cilium intersection_of: RO:0000053 PATO:0010007 ! has characteristic multiciliated property_value: terms:contributor https://orcid.org/0009-0000-8480-9277 property_value: terms:date "2024-08-20T10:06:15Z" xsd:dateTime [Term] id: CL:4052002 name: syncytial cell def: "A multinucleate cell formed by the fusion of multiple uninuclear cells through plasma membrane fusion. This process leads to a single large cell containing multiple nuclei within a shared cytoplasm." [PMID:20851884, Wikipedia:Syncytium] subset: human_subset subset: mouse_subset synonym: "SC" RELATED OMO:0003000 [PMID:9067520] synonym: "syncytium" EXACT [WBbt:0008074] is_a: BFO:0000002 is_a: CL:0000228 ! multinucleate cell intersection_of: CL:0000000 ! cell intersection_of: RO:0000053 PATO:0001908 ! has characteristic multinucleate intersection_of: RO:0002353 GO:0000768 ! output of syncytium formation by plasma membrane fusion relationship: RO:0002353 GO:0000768 ! output of syncytium formation by plasma membrane fusion property_value: skos:prefLabel "syncytial cell" xsd:string property_value: terms:contributor https://orcid.org/0009-0000-8480-9277 property_value: terms:date "2024-08-15T10:38:46Z" xsd:dateTime [Term] id: CL:4052003 name: intestinal villus capillary endothelial cell def: "A capillary endothelial cell that is part of the intestinal villus. This cell is highly fenestrated, with fenestrations most numerous at the villus tips, and plays a vital role in nutrient absorption and maintaining the selective permeability of the intestinal barrier." [PMID:18480313, PMID:35810168, PMID:38051275] subset: human_subset subset: mouse_subset synonym: "villus blood capillary endothelial cells" BROAD [PMID:35810168] synonym: "villus tip endothelial cell" RELATED [PMID:38051275] is_a: CL:0000131 ! gut endothelial cell is_a: CL:0000666 ! fenestrated endothelial cell is_a: CL:0002144 ! capillary endothelial cell intersection_of: CL:0002144 ! capillary endothelial cell intersection_of: BFO:0000050 UBERON:0001213 ! part of intestinal villus relationship: BFO:0000050 UBERON:0001213 ! part of intestinal villus property_value: terms:contributor https://orcid.org/0009-0000-8480-9277 property_value: terms:date "2024-09-17T10:03:25Z" xsd:dateTime [Term] id: CL:4052004 name: intestinal fibroblastic reticular cell def: "A specialized fibroblastic reticular cell that is part of gut-associated lymphoid tissue (GALT), responsible for forming a structural network that facilitates immune cell interactions. This cell is found in Peyer's patches, cryptopatches, and isolated lymphoid follicles. It plays crucial roles in maintaining intestinal immunity by controlling innate lymphoid cell homeostasis and function, organizing lymphoid structures, and contributing to intestinal microbiome balance." [PMID:33707780, PMID:35440118] subset: human_subset subset: mouse_subset synonym: "Ccl19-expressing fibroblastic reticular cell" NARROW [PMID:35440118] synonym: "gut-associated secondary lymphoid organs fibroblastic reticular cell" RELATED [PMID:35440118] synonym: "solitary intestinal lymphoid tissue fibroblastic reticular cell" NARROW [PMID:35440118] is_a: CL:0009101 ! fibroblastic reticular cell relationship: BFO:0000050 UBERON:0001962 ! part of gut-associated lymphoid tissue property_value: terms:contributor https://orcid.org/0009-0000-8480-9277 property_value: terms:date "2024-09-19T11:22:18Z" xsd:dateTime property_value: terms:description "Intestinal fibroblastic reticular cells develop from both perivascular and subepithelial progenitors during Peyer's patch formation. Intestinal fibroblastic reticular cells express key markers such as CCL19, CCL21, CXCL13, TNFSF13B (also known as BAFF), and produce IL-7, which are important for their immune regulatory functions and the organization of lymphoid structures." xsd:string {xref="PMID:33707780", xref="PMID:35440118"} [Term] id: CL:4052005 name: intestinal subserosal fibroblast def: "A fibroblast that is part of the subserosa of intestine. This cell interacts with immune cells and play roles in inflammation and fibrosis. In certain conditions, such as Crohn's disease, subserosal fibroblast may differentiate into myofibroblasts." [PMID:23143399, PMID:26694715, PMID:38877292] subset: human_subset subset: mouse_subset is_a: CL:0000057 ! fibroblast relationship: BFO:0000050 UBERON:0001243 ! part of serosa of intestine relationship: BFO:0000050 UBERON:0012375 ! part of subserosa property_value: terms:contributor https://orcid.org/0009-0000-8480-9277 property_value: terms:date "2024-09-19T12:58:29Z" xsd:dateTime [Term] id: CL:4052006 name: intestinal enteroendocrine progenitor def: "An epithelial cell that is part of the crypt of Lieberkuhn, originating from intestinal stem cells and giving rise to enteroendocrine cells (EECs). In mouse and human, this cell can be characterized by the expression of Neurog3, and has the ability to proliferate and differentiate into multiple EEC subtypes. Its proliferative potential contributes to crypt growth, distinguishing it from fully differentiated EECs." [doi:/10.1038/s41467-021-27901-5, PMID:31756561, PMID:32531023, PMID:35913117, PMID:38260422] comment: The EEC progenitor is also present in other organisms; for example, flies have EEC progenitors but lack intestinal crypts and do not express the same markers. Instead, they are Dl+ and Pros+. {xref="PMID:25670791"} subset: human_subset subset: mouse_subset synonym: "EEC Progenitor" RELATED OMO:0003000 [PMID:31756561] is_a: CL:0002563 ! intestinal epithelial cell is_a: CL:0011026 ! progenitor cell relationship: BFO:0000050 UBERON:0011184 ! part of epithelium of crypt of Lieberkuhn relationship: RO:0002202 CL:0002250 ! develops from intestinal crypt stem cell property_value: terms:contributor https://orcid.org/0009-0000-8480-9277 property_value: terms:date "2024-09-20T12:13:26Z" xsd:dateTime [Term] id: CL:4052007 name: subepithelial intestinal fibroblast def: "A fibroblast located adjacent to the intestinal epithelium in both the small intestine and colon, specifically around the crypts. This cell is characterized by the expression of PDGFRα and various collagen isoforms, including COL4A5 and COL4A6. It secretes signalling molecules like TGF-β, Wnt ligands, and BMPs, which are crucial for epithelial homeostasis, intestinal stem cell support, and basement membrane formation." [PMID:30270042, PMID:33430285, PMID:33916891, PMID:37080817] comment: The S2 fibroblast population has been identified as a subset of intestinal fibroblasts located near the epithelial lining. This population is divided into two subtypes: S2a and S2b. S2a is involved in epithelial differentiation, while S2b, located at the top of the crypt, regulates intestinal stem cell proliferation, niche formation, and wound healing. {xref="PMID:30270042", xref="PMID:33916891", xref="PMID:37495570"} subset: human_subset subset: mouse_subset synonym: "S2 fibroblast" RELATED [PMID:30270042, PMID:33916891] synonym: "S2 mesenchymal cells" RELATED [PMID:33916891] is_a: CL:0000057 ! fibroblast relationship: RO:0002220 UBERON:0001277 ! adjacent to intestinal epithelium property_value: terms:contributor https://orcid.org/0009-0000-8480-9277 property_value: terms:date "2024-09-23T09:59:27Z" xsd:dateTime [Term] id: CL:4052008 name: crypt-bottom fibroblast def: "A subepithelial intestinal fibroblast that is located adjacent to the base of the crypt of Lieberkühn, near the intestinal stem cells. Characterized by low PDGFRα expression, this cell is crucial for maintaining the intestinal stem cell niche. Crypt-bottom fibroblast secretes key signaling molecules including canonical Wnt ligands (Wnt2, Wnt2b), Wnt potentiators (Rspo3), and BMP inhibitors (Grem1), which collectively regulate intestinal stem cell function and epithelial homeostasis." [doi:/10.1371/journal.pbio.3001032, PMID:33916891] subset: human_subset subset: mouse_subset synonym: "bottom pericryptic-associated fibroblasts" RELATED [PMID:33916891] synonym: "CBFs" RELATED OMO:0003000 [doi:/10.1371/journal.pbio.3001032] is_a: CL:4052007 ! subepithelial intestinal fibroblast relationship: RO:0002220 CL:0002250 ! adjacent to intestinal crypt stem cell relationship: RO:0002220 UBERON:0013739 ! adjacent to base of crypt of Lieberkuhn property_value: terms:contributor https://orcid.org/0009-0000-8480-9277 property_value: terms:date "2024-09-23T10:23:18Z" xsd:dateTime [Term] id: CL:4052009 name: crypt-top fibroblast def: "A subepithelial intestinal fibroblast that is located adjacent to the top of the crypt of Lieberkuhn. Characterized by high experession of PDGFRα, this cell secretes a range of signaling factors, including WNTs and BMPs, that drive epithelial differentiation, creating a gradient that regulates the balance between stem cell maintenance and differentiation." [doi:/10.1371/journal.pbio.3001032, PMID:33916891] comment: S2b fibroblasts are located at the top of the crypt and express NRG1 and NPY. {xref="PMID:37495570"} subset: human_subset subset: mouse_subset synonym: "CTFs" RELATED OMO:0003000 [doi:/10.1371/journal.pbio.3001032] synonym: "S2b fibroblast" RELATED [PMID:37495570] synonym: "top pericryptic fibroblast" RELATED [PMID:33916891] is_a: CL:4052007 ! subepithelial intestinal fibroblast relationship: RO:0002220 UBERON:0013740 ! adjacent to wall of crypt of Lieberkuhn property_value: terms:contributor https://orcid.org/0009-0000-8480-9277 property_value: terms:date "2024-09-23T11:14:04Z" xsd:dateTime [Term] id: CL:4052010 name: pre-theca cell def: "A stromal cell that serves as a precursor to the theca cell layers in the ovary growing follicles. This cell is present in the early stages of follicular growth, particularly in smaller follicles. Unlike mature theca cell, a pre-theca cell is initially non-steroidogenic and lacks luteinizing hormone receptors." [PMID:20628033, PMID:31320652, PMID:36205477] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "early theca cell" EXACT [PMID:36205477] synonym: "progenitor theca cell" EXACT [PMID:31320652] is_a: CL:0002132 ! stromal cell of ovary is_a: CL:0002174 ! follicular cell of ovary relationship: BFO:0000050 UBERON:0012186 ! part of ovary growing follicle relationship: RO:0002203 CL:0000503 ! develops into theca cell property_value: terms:contributor https://orcid.org/0009-0000-8480-9277 property_value: terms:date "2024-09-25T11:15:57Z" xsd:dateTime [Term] id: CL:4052011 name: follicle associated enterocyte def: "An enterocyte found in the follicle-associated epithelium (FAE) that covers Peyer's patches and other mucosa-associated lymphoid tissues. This cell has reduced absorptive capacity and expresses higher levels of chemokines CCL20 and CXCL16, compared to regular villus enterocytes. It contributes to antigen sampling and immune interactions, supporting the specialized function of the FAE in mucosal immunity." [PMID:29339448, PMID:34634036, PMID:7107724] subset: human_subset subset: mouse_subset synonym: "FAE enterocyte" RELATED OMO:0003000 [PMID:7107724] synonym: "follicle-associated epithelium enterocyte" EXACT [PMID:7107724] synonym: "follicular enterocyte" RELATED [PMID:7107724] is_a: CL:0000584 ! enterocyte relationship: BFO:0000050 UBERON:0004693 ! part of Peyer's patch epithelium property_value: terms:contributor https://orcid.org/0009-0000-8480-9277 property_value: terms:date "2024-09-25T15:28:25Z" xsd:dateTime [Term] id: CL:4052012 name: interna theca cell def: "A specialized theca cell that forms the inner, highly vascularized layer of the theca surrounding ovarian follicles. Originating from progenitor theca cells, the theca interna cell is steroidogenic, playing a crucial role in the production of androgens, which serves as a precursor for estrogen synthesis in granulosa cells. This cell expresses luteinizing hormone receptors, enabling it to respond to hormonal signals that regulate steroidogenesis." [PMID:15833266, PMID:31320652, PMID:32530882, Wikipedia:Theca_interna] subset: human_subset subset: mouse_subset synonym: "androgenic theca cell" RELATED [PMID:36599970] synonym: "inTC" RELATED OMO:0003000 [PMID:31320652] synonym: "interna TC" RELATED OMO:0003000 [PMID:31320652] synonym: "steroidogenic theca interna cell" RELATED [PMID:36599970] is_a: CL:0000503 ! theca cell is_a: CL:0000593 ! androgen secreting cell intersection_of: CL:0000503 ! theca cell intersection_of: BFO:0000050 UBERON:0000157 ! part of theca interna disjoint_from: CL:4052013 ! externa theca cell relationship: BFO:0000050 UBERON:0000157 ! part of theca interna relationship: RO:0002202 CL:4052010 ! develops from pre-theca cell property_value: terms:contributor https://orcid.org/0009-0000-8480-9277 property_value: terms:date "2024-09-30T11:10:15Z" xsd:dateTime [Term] id: CL:4052013 name: externa theca cell def: "A specialized theca cell that forms the outer layer of the theca surrounding the ovarian follicle, appearing at the antral follicle. Originating from progenitor theca cells, theca externa cell is characterized by its fibroblast-like appearance and primarily function to provide structural support to the developing follicle. This cell produces collagen fibers and extracellular matrix components such as Col1a1 and Col1a2." [PMID:31320652, PMID:32530882, PMID:36758341, Wikipedia:Theca_externa] subset: human_subset subset: mouse_subset synonym: "exTC" RELATED OMO:0003000 [PMID:31320652] synonym: "externa TC" RELATED OMO:0003000 [PMID:31320652] synonym: "structural theca cell" RELATED [PMID:36599970] is_a: CL:0000503 ! theca cell intersection_of: CL:0000503 ! theca cell intersection_of: BFO:0000050 UBERON:0000156 ! part of theca externa relationship: BFO:0000050 UBERON:0000156 ! part of theca externa relationship: RO:0002202 CL:4052010 ! develops from pre-theca cell property_value: terms:contributor https://orcid.org/0009-0000-8480-9277 property_value: terms:date "2024-09-30T11:10:15Z" xsd:dateTime [Term] id: CL:4052014 name: pancreatic islet capillary endothelial cell def: "A capillary endothelial cell that is part of islet of Langerhans, characterized by a high density of fenestrations —approximately ten times greater than those in exocrine pancreatic capillaries. These fenestrations facilitate efficient hormone exchange, which is essential for maintaining glucose homeostasis. The cell's structure and function are regulated by the local production of vascular endothelial growth factor-A (VEGF-A), which maintains its fenestrated architecture." [PMID:16607697, PMID:27124642, PMID:28396983, PMID:33200981] subset: human_subset subset: mouse_subset synonym: "islet endothelial cell" BROAD [PMID:16607697, PMID:28396983] synonym: "pancreatic islet endothelial cell" BROAD [PMID:16607697] is_a: CL:0000666 ! fenestrated endothelial cell is_a: CL:0002144 ! capillary endothelial cell intersection_of: CL:0002144 ! capillary endothelial cell intersection_of: BFO:0000050 UBERON:0000006 ! part of islet of Langerhans relationship: BFO:0000050 UBERON:0000006 ! part of islet of Langerhans property_value: terms:contributor https://orcid.org/0009-0000-8480-9277 property_value: terms:date "2024-09-30T14:36:12Z" xsd:dateTime [Term] id: CL:4052015 name: endocrine gland capillary endothelial cell def: "Any capillary endothelial cell that is part of an endocrine gland." [PMID:18480313] subset: human_subset subset: mouse_subset is_a: CL:0002144 ! capillary endothelial cell intersection_of: CL:0002144 ! capillary endothelial cell intersection_of: BFO:0000050 UBERON:0002368 ! part of endocrine gland relationship: BFO:0000050 UBERON:0002368 ! part of endocrine gland property_value: terms:contributor https://orcid.org/0009-0000-8480-9277 property_value: terms:date "2024-09-30T15:27:49Z" xsd:dateTime [Term] id: CL:4052016 name: pituitary gland capillary endothelial cell def: "A capillary endothelial cell that is part of the pituitary gland. This cell is characterized by its fenestrated structure which facilitates the efficient transport of hormones and other signaling molecules, essential for endocrine signalling." [PMID:10810312, PMID:32910242] comment: In the anterior pituitary gland of rats, capillary endothelial cells are distinguished by numerous fenestrations, which are covered by a single-layered diaphragm. The diaphragm features a dense ring-like structure. {xref="PMID:4899902"} subset: human_subset subset: mouse_subset is_a: CL:0000666 ! fenestrated endothelial cell is_a: CL:2000004 ! pituitary gland cell is_a: CL:2000044 ! brain microvascular endothelial cell is_a: CL:4052015 ! endocrine gland capillary endothelial cell intersection_of: CL:0002144 ! capillary endothelial cell intersection_of: BFO:0000050 UBERON:0000007 ! part of pituitary gland property_value: terms:contributor https://orcid.org/0009-0000-8480-9277 property_value: terms:date "2024-09-30T15:31:45Z" xsd:dateTime [Term] id: CL:4052017 name: choroid plexus capillary endothelial cell def: "A capillary endothelial cell that is part of the choroid plexus, characterized by its fenestrated nature with 60 to 80 nm fenestrations and lack of tight junctions. This fenestrated structure allows for the rapid delivery of water and other components, aiding in the production of cerebrospinal fluid (CSF)." [https://www.ncbi.nlm.nih.gov/books/NBK27998/, PMID:18480313, PMID:32375819] subset: human_subset subset: mouse_subset is_a: CL:0000666 ! fenestrated endothelial cell is_a: CL:0002144 ! capillary endothelial cell is_a: CL:2000044 ! brain microvascular endothelial cell intersection_of: CL:0002144 ! capillary endothelial cell intersection_of: BFO:0000050 UBERON:0001886 ! part of choroid plexus relationship: BFO:0000050 UBERON:0001886 ! part of choroid plexus property_value: terms:contributor https://orcid.org/0009-0000-8480-9277 property_value: terms:date "2024-10-01T11:38:22Z" xsd:dateTime [Term] id: CL:4052018 name: fallopian tube epithelial cell def: "Any epithelial cell that is part of the fallopian tube." [Wikipedia:Fallopian_tube] subset: human_subset subset: mouse_subset synonym: "oviduct epithelial cell" BROAD [Wikipedia:Fallopian_tube] synonym: "uterine tube epithelial cell" EXACT [Wikipedia:Fallopian_tube] is_a: CL:0000066 ! epithelial cell intersection_of: CL:0000066 ! epithelial cell intersection_of: BFO:0000050 UBERON:0003889 ! part of fallopian tube relationship: BFO:0000050 UBERON:0003889 ! part of fallopian tube property_value: terms:contributor https://orcid.org/0009-0000-8480-9277 property_value: terms:date "2024-10-01T12:09:12Z" xsd:dateTime [Term] id: CL:4052019 name: fallopian tube non-ciliated epithelial cell def: "Any epithelial cell that is part of the fallopian tube and lacks cilia." [] subset: human_subset subset: mouse_subset synonym: "fallopian tube non-ciliated cell" EXACT [] is_a: CL:4052018 ! fallopian tube epithelial cell relationship: CL:4030045 GO:0005929 ! lacks_part cilium property_value: terms:contributor https://orcid.org/0009-0000-8480-9277 property_value: terms:date "2024-10-01T12:12:12Z" xsd:dateTime [Term] id: CL:4052020 name: lung resident granzyme K-associated CD8 T cell def: "A granzyme K-associated CD8 T cell that resides in the lung, characterized by the expression of granzyme K (GZMK), and tissue residency markers CD103 and CD49a. This cell exhibits cytotoxic potential through its expression of multiple granzymes (GZMA, GZMB, GZMH, GZMM) in addition to GZMK." [doi:/10.1101/2022.06.17.496207] comment: Lung resident granzyme K-associated CD8 T cell represents an intermediate stage of T cell differentiation, with GZMK expression peaking during this phase. {xref="PMID:28322863", xref="doi:/10.1101/2022.06.17.496207"} subset: human_subset subset: mouse_subset synonym: "lung resident CD8-GZMK" RELATED OMO:0003000 [doi:/10.1101/2022.06.17.496207] is_a: CL:4033040 ! lung resident memory CD8-positive, CD103-positive, alpha-beta T cell is_a: CL:4052021 ! granzyme K-associated CD8 T cell intersection_of: CL:4033040 ! lung resident memory CD8-positive, CD103-positive, alpha-beta T cell intersection_of: RO:0002292 PR:000003472 ! expresses granzyme K property_value: terms:contributor https://orcid.org/0000-0002-2336-2552 property_value: terms:contributor https://orcid.org/0009-0000-8480-9277 property_value: terms:date "2024-10-14T15:42:41Z" xsd:dateTime [Term] id: CL:4052021 name: granzyme K-associated CD8 T cell def: "A CD8 T cell characterized by high expression of Granzyme K (GZMK). This cell is enriched in both inflamed tissues, such as synovial tissue in rheumatoid arthritis and respiratory tissues during COVID-19, as well as non-inflamed tissues like the gut and kidneys. Unlike highly cytotoxic GZMB+ CD8+ T cell, GZMK+ CD8+ T cell exhibits lower direct cytotoxic potential, and is involved in producing pro-inflammatory cytokines such as IFN-γ and TNF-α." [PMID:35704599, PMID:37449888] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "CD8-GZMK cell" RELATED OMO:0003000 [doi:/10.1101/2022.06.17.496207] synonym: "granzyme K+ CD8 T cell" EXACT [PMID:35704599] synonym: "GZMK high CD8+ T effector memory cell" NARROW [PMID:36347862] synonym: "tissue-enriched expressing GzmK CD8 cell" EXACT [PMID:35704599] synonym: "TteK CD8 cell" RELATED OMO:0003000 [PMID:35704599] is_a: CL:0000909 ! CD8-positive, alpha-beta memory T cell intersection_of: CL:0000909 ! CD8-positive, alpha-beta memory T cell intersection_of: RO:0002292 PR:000003472 ! expresses granzyme K relationship: RO:0002292 PR:000003472 ! expresses granzyme K property_value: terms:contributor https://orcid.org/0009-0000-8480-9277 property_value: terms:date "2024-10-18T09:51:48Z" xsd:dateTime [Term] id: CL:4052022 name: fallopian tube smooth muscle cell def: "A smooth muscle cell that is part of the fallopian tube. This cell is responsible for peristaltic contractions that facilitate gamete and embryo transport, fluid mixing, and embryo admission to the uterus." [PMID:31183831, PMID:31613440] comment: The fallopian tube smooth muscle cell in the human contracts dynamically in response to hormones and signaling molecules. Prostaglandins, particularly PGF2α and PGE2, have been shown to increase muscular contractions, while progesterone, levonorgestrel, mifepristone, oxytocin, and human chorionic gonadotropin (hCG) decrease them. These contractile responses are crucial for regulating gamete and embryo transport through the fallopian tube. {xref="PMID:18621753"} subset: human_subset subset: mouse_subset synonym: "oviduct smooth muscle cell" BROAD [PMID:31613440] synonym: "uterine tube smooth muscle cell" EXACT [PMID:31613440] is_a: CL:0000192 ! smooth muscle cell intersection_of: CL:0000192 ! smooth muscle cell intersection_of: BFO:0000050 UBERON:0003889 ! part of fallopian tube relationship: BFO:0000050 UBERON:0003889 ! part of fallopian tube property_value: terms:contributor https://orcid.org/0009-0000-8480-9277 property_value: terms:date "2024-10-21T12:16:54Z" xsd:dateTime [Term] id: CL:4052023 name: luminal endometrial unciliated epithelial cell def: "An epithelial cell that is part of the endometrial luminal epithelium, forming a continuous layer lining the uterine cavity. This cell undergoes cyclical changes during the menstrual cycle, proliferating under estrogen in the proliferative phase, and differentiating under progesterone in the secretory phase to prepare for potential implantation. During the window of implantation, this cell changes from a tall columnar shape to a shorter columnar or cuboidal form, loses polarity, and becomes receptive to blastocyst implantation." [PMID:32929266, PMID:36581776, PMID:38559249, PMID:39198675] comment: The luminal endometrial unciliated epithelial cell expresses WNT7A, and LGR5 during the proliferative phase, transitioning to express VTCN1 and SULT1E1 in the early secretory phase, and LEFTY1, IL6, and PTGS1 in the mid- to late-secretory phases. {xref="PMID:39198675"} subset: human_subset subset: mouse_subset is_a: CL:1001591 ! oviduct secretory cell is_a: CL:4052050 ! luminal epithelial cell of endometrium intersection_of: CL:0000066 ! epithelial cell intersection_of: BFO:0000050 UBERON:0011949 ! part of endometrium luminal epithelium intersection_of: RO:0002215 GO:0032940 ! capable of secretion by cell property_value: terms:contributor https://orcid.org/0009-0000-8480-9277 property_value: terms:date "2024-10-22T12:02:23Z" xsd:dateTime [Term] id: CL:4052024 name: myotendinous junction nucleus def: "A specialized muscle nucleus that is part of an extrafusal muscle fiber and overlaps the muscle-tendon junction, where muscle fibers connect to tendons. Characterized by a distinct transcriptional profile with the expression of genes like COL22A1, this myonucleus supports the structural integrity and function of the junction, playing a key role in transmitting the force generated by muscle contraction to the tendon." [PMID:33311457, PMID:33311464, PMID:38398025] subset: cellxgene_subset synonym: "MTJ nucleus" RELATED OMO:0003000 [] synonym: "myotendinous junction myonuclei" EXACT OMO:0003004 [PMID:33311464] synonym: "myotendinous junction nuclei" EXACT OMO:0003004 [PMID:33311457] is_a: GO:0005634 ! nucleus intersection_of: GO:0005634 ! nucleus intersection_of: BFO:0000050 CL:0008046 ! part of extrafusal muscle fiber intersection_of: RO:0002131 GO:0005927 ! overlaps muscle tendon junction relationship: BFO:0000050 CL:0008046 ! part of extrafusal muscle fiber relationship: RO:0002131 GO:0005927 ! overlaps muscle tendon junction property_value: terms:contributor https://orcid.org/0009-0000-8480-9277 property_value: terms:contributor https://orcid.org/0009-0001-6947-615X property_value: terms:date "2024-10-30T13:47:39Z" xsd:dateTime [Term] id: CL:4052025 name: neuromuscular junction nucleus def: "A specialized muscle nucleus that is part of an extrafusal muscle fiber, clustered at the postsynaptic side of the neuromuscular junction. This nucleus exhibits a distinct transcriptional profile, including acetylcholine receptor (AChR) subunit genes. It regulates the production of proteins essential for maintaining the structure and function of the neuromuscular junction, supporting efficient nerve-muscle signaling for muscle contraction." [PMID:33037211, PMID:33311457, PMID:33311464] subset: cellxgene_subset synonym: "neuromuscular junction myonuclei" EXACT OMO:0003004 [PMID:33311464] synonym: "neuromuscular junction nuclei" EXACT OMO:0003004 [PMID:33311457] synonym: "NMJ nuclues" RELATED OMO:0003000 [] is_a: GO:0005634 ! nucleus intersection_of: GO:0005634 ! nucleus intersection_of: BFO:0000050 CL:0008046 ! part of extrafusal muscle fiber intersection_of: RO:0002131 GO:0098522 ! overlaps neuromuscular junction of skeletal muscle fiber relationship: BFO:0000050 CL:0008046 ! part of extrafusal muscle fiber relationship: RO:0002131 GO:0098522 ! overlaps neuromuscular junction of skeletal muscle fiber property_value: terms:contributor https://orcid.org/0009-0000-8480-9277 property_value: terms:contributor https://orcid.org/0009-0001-6947-615X property_value: terms:date "2024-10-31T11:09:04Z" xsd:dateTime [Term] id: CL:4052026 name: type IIx muscle cell def: "A fast type II muscle cell that is part of the skeletal muscle tissue. This cell is characterized by its intermediate metabolic profile, utilizing both glycolytic and oxidative pathways for energy production. In humans, it is distinguished by the expression of myosin heavy chain 1 (MYH1)." [doi:10.1101/2024.05.15.594276, PMID:34727990, PMID:35908794, PMID:36361732] comment: In humans, type IIx fiber contains high levels of MYLK2, enhancing contraction speed and force via myosin phosphorylation, especially under low calcium. This mechanism supports post-activation potentiation, increasing force output in fast-twitch muscles. Additionally, this fiber has abundant ACTN3 (α-actinin-3), linked to muscle power, and exhibits the highest shortening velocity among human muscle fiber types. Notably, type IIx fiber is selectively lost in aging-related sarcopenia, increases in proportion in type 2 diabetes and obesity, and is the first to degenerate in Duchenne Muscular Dystrophy, impacting muscle function across various conditions. {xref="PMID:27199166", xref="PMID:34727990"} subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "type 2x fiber" EXACT [PMID:34727990] synonym: "type 2x muscle cell" EXACT [PMID:34727990] synonym: "type 2x muscle fiber" EXACT [PMID:34727990] synonym: "type IIx muscle fiber" EXACT [doi:10.1101/2024.05.15.594276] is_a: CL:0002212 ! type II muscle cell property_value: terms:contributor https://orcid.org/0009-0000-8480-9277 property_value: terms:date "2024-11-04T10:26:29Z" xsd:dateTime [Term] id: CL:4052027 name: atretic theca cell def: "A theca cell undergoing atresia, characterized by distinct morphological changes including hypertrophy, altered cell shape, and disrupted layered organization. This cell exhibits reduced steroidogenic capacity and changes in surrounding vascularization. The onset of theca cell atresia can vary, occurring at different stages of follicle atresia depending on the phase of folliculogenesis." [PMID:20628033, PMID:38069168] comment: During atresia, theca interna and externa cells undergo distinct morphological and functional changes. Theca interna cells round up, expand in cytoplasmic area, and thicken the internal layer as organization degrades, while showing reduced STAR expression, which lowers androgen production. Theca externa cells display decreased ACTA2 expression, weakening structural integrity. {xref="PMID:38069168"} subset: human_subset subset: mouse_subset is_a: CL:4033089 ! atretic follicular cell of ovary relationship: RO:0002202 CL:0000503 ! develops from theca cell property_value: terms:contributor https://orcid.org/0009-0000-8480-9277 property_value: terms:date "2024-11-06T10:10:51Z" xsd:dateTime [Term] id: CL:4052028 name: uterine natural killer cell def: "A natural killer cell that is part of the uterus, specifically within the endometrium during the non-pregnant state and in the decidua during pregnancy. This cell exhibits dynamic changes in frequency throughout the menstrual cycle, with lower levels during menstruation and a significant increase during the mid-secretory phase and early pregnancy." [PMID:35720413, PMID:39198675, Wikipedia:Uterine_natural_killer_cells] subset: human_subset subset: mouse_subset synonym: "endometrial natural killer cell" NARROW [PMID:35720413] synonym: "uNK cell" RELATED OMO:0003000 [PMID:39198675] is_a: CL:0000623 ! natural killer cell intersection_of: CL:0000623 ! natural killer cell intersection_of: BFO:0000050 UBERON:0000995 ! part of uterus relationship: BFO:0000050 UBERON:0000995 ! part of uterus property_value: terms:contributor https://orcid.org/0009-0000-8480-9277 property_value: terms:date "2024-11-15T10:12:40Z" xsd:dateTime [Term] id: CL:4052029 name: subpleural fibroblast def: "A fibroblast that is located beneath the visceral pleura of the lung. This cell contributes to the development of idiopathic pulmonary fibrosis (IPF) by forming fibrotic lesions that originate subpleurally and extend into lung tissue through activation, proliferation, migration, and differentiation into a myofibroblast." [PMID:36543915, PMID:36769178, PMID:37291214] subset: human_subset subset: mouse_subset is_a: CL:0002553 ! fibroblast of lung property_value: terms:contributor https://orcid.org/0009-0000-8480-9277 property_value: terms:date "2024-11-29T13:54:15Z" xsd:dateTime [Term] id: CL:4052030 name: adventitial fibroblast def: "A fibroblast of the adventitia of a blood vessel. This cell contributes to vascular homeostasis, remodeling, and inflammation by producing extracellular matrix components, cytokines, and growth factors. Adventitial fibroblast can transition into an activated state during injury or disease, marked by increased proliferation, migration, matrix deposition, and contractile protein expression" [PMID:28705796, PMID:36718802] comment: Single-cell transcriptomics of murine aorta identifies two adventitial fibroblast-specific markers, PDGFRA and DPEP1, which were validated at the protein level by immunohistochemistry and flow cytometry across human and murine arteries, highlighting fibroblast heterogeneity in health and cardiovascular disease (CVD) in humans and mice. {xref="PMID:36718802"} subset: cellxgene_subset subset: human_subset subset: mouse_subset is_a: CL:0000057 ! fibroblast is_a: CL:0000151 ! secretory cell is_a: CL:0002503 ! adventitial cell intersection_of: CL:0000057 ! fibroblast intersection_of: BFO:0000050 UBERON:0005734 ! part of tunica adventitia of blood vessel relationship: BFO:0000050 UBERON:0005734 ! part of tunica adventitia of blood vessel relationship: RO:0002215 GO:0001816 ! capable of cytokine production relationship: RO:0002215 GO:0070278 ! capable of extracellular matrix constituent secretion property_value: terms:contributor https://orcid.org/0009-0000-8480-9277 property_value: terms:date "2024-12-05T11:01:15Z" xsd:dateTime [Term] id: CL:4052031 name: respiratory airway secretory cell def: "A secretory epithelial cell of the respiratory and terminal bronchioles." [PMID:35355013, PMID:36796082] comment: The respiratory airway secretory cell is cuboidal and has a unique transcriptomic profile compared to other epithelial cells in the same region. In humans, it functions as a multipotent progenitor, capable of regenerating alveolar type 2 (AT2) cells. {xref="PMID:36796082", xref="PMID:35355013"} subset: human_subset subset: mouse_subset synonym: "RAS cell" RELATED OMO:0003000 [PMID:36796082] synonym: "terminal and respiratory bronchioles secretory cell" RELATED [PMID:35355018] is_a: CL:0000082 ! epithelial cell of lung is_a: CL:0002202 ! epithelial cell of tracheobronchial tree is_a: CL:0008055 ! respiratory tract secretory epithelial cell is_a: CL:1000272 ! lung secretory cell relationship: BFO:0000050 UBERON:0002051 ! part of epithelium of bronchiole property_value: terms:contributor https://orcid.org/0009-0000-8480-9277 property_value: terms:date "2024-11-29T16:14:31Z" xsd:dateTime [Term] id: CL:4052032 name: granzyme H-associated CD8 T cell def: "A CD8 T cell characterized by high expression of Granzyme H (GZMH). This cell exhibits a restricted TCR repertoire and elevated expression of cytotoxic, exhaustion, and type I interferon-stimulated gene signatures compared to controls." [PMID:35389781] comment: This cell type is significantly expanded in systemic lupus erythematosus (SLE) patients. Unlike other CD8 T cell populations, GZMH+ CD8 T cells can comprise up to 50% of all lymphocytes in some SLE patients. {xref="PMID:35389781"} subset: human_subset subset: mouse_subset synonym: "granzyme H+ CD8 T cell" EXACT [PMID:35389781] synonym: "GZMH+ CD8+ T cell" RELATED OMO:0003000 [PMID:35389781] is_a: CL:0000909 ! CD8-positive, alpha-beta memory T cell intersection_of: CL:0000909 ! CD8-positive, alpha-beta memory T cell intersection_of: RO:0002292 PR:000003490 ! expresses granzyme H relationship: RO:0002292 PR:000003490 ! expresses granzyme H property_value: terms:contributor https://orcid.org/0000-0002-3958-7465 property_value: terms:contributor https://orcid.org/0009-0000-8480-9277 property_value: terms:date "2025-01-10T10:14:31Z" xsd:dateTime [Term] id: CL:4052033 name: biliary tuft cell def: "A tuft cell that is part of the extrahepatic biliary tree, including the gallbladder and extrahepatic bile ducts. It shares a core genetic program with intestinal tuft cells but has unique tissue-specific genes. Biliary tuft cell functions as a bile acid-sensitive regulator, suppressing inflammation and modulating microbiome-dependent neutrophil infiltration in biliary tissues. Unlike its intestinal counterparts, this cell decreases in number postnatally as bile acid production matures, with its abundance negatively regulated by bile acids." [PMID:35245089, PMID:37863104] subset: human_subset subset: mouse_subset synonym: "gallbladder/extrahepatic bile duct tuft cell" EXACT [PMID:35245089] is_a: CL:0002204 ! tuft cell relationship: RO:0002215 GO:0050728 ! capable of negative regulation of inflammatory response property_value: terms:contributor https://orcid.org/0009-0000-8480-9277 property_value: terms:date "2025-01-20T14:39:06Z" xsd:dateTime [Term] id: CL:4052034 name: tuft cell of thymus def: "A tuft cell that is part of the medullary epithelium of the thymus, characterized by lateral microvilli and specific markers, including L1CAM in both mice (Zhang et al., 2022) and humans (Sun et al., 2023), as well as MHC II in mice (Miller et al., 2018). This cell is pivotal in immune functions such as antigen presentation, central tolerance, and type 2 immunity. A tuft cell in the thymus exhibits characteristics of both a medullary thymic epithelial cell (mTEC) and a peripheral tuft cell. Its development is governed by transcription factors such as POU2F3." [PMID:30022164, PMID:30904566, PMID:35668088, PMID:36351364, PMID:36961668] comment: A thymic tuft cell is a subset of terminally differentiated medullary thymic epithelial cell comprising 5-10% of total mTECs. Lineage-tracing studies indicate that this cell arises from mature MHCII mTECs, with development occurring through both Aire-dependent and Aire-independent pathways. However, its exact origins remain unclear. {xref="PMID:30904566"} subset: human_subset subset: mouse_subset synonym: "thymic tuft cell" EXACT [PMID:30904566] is_a: CL:0002204 ! tuft cell is_a: CL:0002365 ! medullary thymic epithelial cell intersection_of: CL:0002204 ! tuft cell intersection_of: BFO:0000050 UBERON:0003846 ! part of thymus epithelium relationship: BFO:0000050 UBERON:0003846 ! part of thymus epithelium relationship: RO:0002215 GO:0002491 ! capable of antigen processing and presentation of endogenous peptide antigen via MHC class II property_value: terms:contributor https://orcid.org/0009-0000-8480-9277 property_value: terms:date "2025-01-16T11:29:54Z" xsd:dateTime [Term] id: CL:4052035 name: tuft cell of pancreatic duct def: "A tuft cell that is part of the epithelium of pancreatic duct. Present in humans and rats, this cell is absent in the murine pancreas under normal conditions but emerges during acinar-to-ductal metaplasia triggered by injury, inflammation, or oncogenic mutations. It modulates the immune response and protects against pancreatic ductal adenocarcinoma progression by producing suppressive eicosanoids, such as prostaglandin D2. A tuft cell in the pancreatic duct highly expresses the transcription factor POU2F3, which is essential for its development and presence." [PMID:30904566, PMID:32717220] subset: human_subset subset: mouse_subset synonym: "pancreatic brush cell" EXACT [PMID:9749964] synonym: "pancreatic tuft cell" EXACT [PMID:32717220] is_a: CL:0000068 ! duct epithelial cell is_a: CL:0002204 ! tuft cell is_a: CL:1001433 ! epithelial cell of exocrine pancreas intersection_of: CL:0002204 ! tuft cell intersection_of: BFO:0000050 UBERON:0009970 ! part of epithelium of pancreatic duct relationship: BFO:0000050 UBERON:0009970 ! part of epithelium of pancreatic duct property_value: terms:contributor https://orcid.org/0009-0000-8480-9277 property_value: terms:date "2025-01-16T11:50:08Z" xsd:dateTime [Term] id: CL:4052036 name: tuft cell of nasal cavity def: "A tuft cell that is part of the nasal cavity epithelium, located in both the respiratory and olfactory epithelia of the nose. This cell plays key roles in chemosensation, lipid mediator production, immune responses, and epithelial homeostasis." [PMID:30379593, PMID:38306414] subset: human_subset subset: mouse_subset synonym: "nasal brush cell" EXACT [PMID:34692913] synonym: "nasal tuft cell" EXACT [PMID:38306414] is_a: CL:0002204 ! tuft cell is_a: CL:0002631 ! epithelial cell of upper respiratory tract intersection_of: CL:0002204 ! tuft cell intersection_of: BFO:0000050 UBERON:0005384 ! part of nasal cavity epithelium relationship: BFO:0000050 UBERON:0005384 ! part of nasal cavity epithelium property_value: terms:contributor https://orcid.org/0009-0000-8480-9277 property_value: terms:date "2025-01-21T09:04:03Z" xsd:dateTime [Term] id: CL:4052037 name: tuft cell of olfactory epithelium def: "A tuft cell that is part of the olfactory epithelium, characterized by a globular body and the expression of neurogranin (Nrgn) in mice. This cell plays a crucial role in allergen recognition and regulating olfactory stem cell proliferation via TRPM5-dependent ATP sensing and cysteinyl leukotriene production. Unlike nasal respiratory tuft cells, it has low to absent expression of taste receptors, including the G protein Gα gustducin, and rarely contacts olfactory sensory neurons directly." [doi:/10.1101/2022.09.26.509561, PMID:38306414] subset: human_subset subset: mouse_subset synonym: "olfactory tuft cell" EXACT [PMID:38306414] synonym: "TPRM5+ tuft-MVC" RELATED [PMID:38306414] synonym: "TRPM5+ microvillous cell" RELATED [PMID:38306414] synonym: "TRPM5+ microvillous tuft cell" RELATED [doi:/10.1101/2022.09.26.509561] synonym: "tuft-microvillous cell" RELATED [PMID:38306414] is_a: CL:0002167 ! olfactory epithelial cell is_a: CL:4052036 ! tuft cell of nasal cavity intersection_of: CL:0002204 ! tuft cell intersection_of: BFO:0000050 UBERON:0001997 ! part of olfactory epithelium relationship: RO:0002215 GO:0072091 ! capable of regulation of stem cell proliferation property_value: terms:contributor https://orcid.org/0009-0000-8480-9277 property_value: terms:date "2025-02-06T15:03:53Z" xsd:dateTime [Term] id: CL:4052038 name: tuft cell of nasal cavity respiratory epithelium def: "A tuft cell that is part of the nasal cavity respiratory epithelium. Acting as a chemosensor, it detects bitter taste ligands and bacterial signals via taste receptors, maintaining epithelial-microbial homeostasis by stimulating antimicrobial peptide secretion from adjacent epithelial cells. This cell is a major source of IL-25, promoting type 2 immune responses and potentially contributing to chronic rhinosinusitis (O'Leary et al., 2019)." [PMID:30379593, PMID:34932383, PMID:38306414] subset: human_subset subset: mouse_subset synonym: "Gɑ-gustducin high respiratory tuft cell" RELATED [PMID:38306414] synonym: "nasal respiratory solitary chemosensory cell" RELATED [PMID:38306414] synonym: "tuft-solitary chemosensory cell" RELATED [PMID:38306414] is_a: CL:4052036 ! tuft cell of nasal cavity intersection_of: CL:0002204 ! tuft cell intersection_of: BFO:0000050 UBERON:0005385 ! part of nasal cavity respiratory epithelium relationship: BFO:0000050 UBERON:0005385 ! part of nasal cavity respiratory epithelium property_value: terms:contributor https://orcid.org/0009-0000-8480-9277 property_value: terms:date "2025-02-06T15:28:14Z" xsd:dateTime [Term] id: CL:4052039 name: tuft cell of submandibular gland def: "A tuft cell that is part of the epithelium of the submandibular gland, localized to the striated ducts in mice, pigs, and humans, and to the main excretory ducts in rats. This cell is characterized by chemosensory functions, potential roles in immune regulation, and possible involvement in salivary secretion via acetylcholine release." [PMID:35993302, PMID:38098741, PMID:8874101] subset: human_subset subset: mouse_subset is_a: CL:0002204 ! tuft cell is_a: CL:0002251 ! epithelial cell of alimentary canal intersection_of: CL:0002204 ! tuft cell intersection_of: BFO:0000050 UBERON:0003359 ! part of epithelium of submandibular gland relationship: BFO:0000050 UBERON:0003359 ! part of epithelium of submandibular gland property_value: terms:contributor https://orcid.org/0009-0000-8480-9277 property_value: terms:date "2025-02-12T10:38:11Z" xsd:dateTime [Term] id: CL:4052040 name: tuft cell of stomach def: "A tuft cell that is part of the epithelium of the stomach. This cell is characterized by gastric chemosensation and immune regulation through IL-25 secretion, which activates ILC2s to produce IL-13, driving epithelial remodelling and tuft cell expansion. Unlike intestinal tuft cells, which are primarily involved in helminth defense and type 2 immunity, the tuft cell of the stomach is primarily involved in inflammation, metaplasia, and hyperplasia." [doi:/10.1101/2022.02.16.480779, PMID:22527717, PMID:38117182] subset: human_subset subset: mouse_subset synonym: "gastric tuft cell" EXACT [PMID:38117182] is_a: CL:0002178 ! epithelial cell of stomach is_a: CL:0002204 ! tuft cell intersection_of: CL:0002204 ! tuft cell intersection_of: BFO:0000050 UBERON:0001276 ! part of epithelium of stomach property_value: terms:contributor https://orcid.org/0009-0000-8480-9277 property_value: terms:date "2025-02-12T11:24:56Z" xsd:dateTime [Term] id: CL:4052041 name: tuft cell of auditory tube def: "A tuft cell that is part of the epithelium of the pharyngotympanic (auditory) tube. This chemosensory cell is often positioned near cholinoreceptive sensory nerve fibers, suggesting a role in neuroimmune communication. It detects chemical signals and releases neuropeptides, such as acetylcholine (ACh) and CGRP, which contribute to inflammatory responses that help protect deeper tissues from harmful substances." [PMID:30379593, PMID:32733896] subset: human_subset subset: mouse_subset is_a: CL:0002204 ! tuft cell is_a: CL:0002491 ! auditory epithelial cell intersection_of: CL:0002204 ! tuft cell intersection_of: BFO:0000050 UBERON:0010062 ! part of pharyngotympanic tube epithelium relationship: BFO:0000050 UBERON:0010062 ! part of pharyngotympanic tube epithelium property_value: terms:contributor https://orcid.org/0009-0000-8480-9277 property_value: terms:date "2025-02-12T12:00:10Z" xsd:dateTime [Term] id: CL:4052042 name: tuft cell of urethra def: "A tuft cell that is part of the epithelium of the urethra. This cell monitors urethral contents by detecting chemical stimuli, such as bitter compounds and sugars. Upon activation, it stimulates sensory nerve fibres and triggers detrusor muscle contraction, likely aiding in pathogen clearance by promoting bladder emptying." [PMID:30379593, PMID:36993541, PMID:38548667] comment: Urethral tuft cells are heterogeneous, with both cholinergic and non-cholinergic populations present. {xref="PMID:27680547"} subset: human_subset subset: mouse_subset synonym: "urethral brush cell" EXACT [PMID:38548667] synonym: "urethral cholinergic chemosensory cell" EXACT [PMID:38548667] synonym: "urethral tuft cell" EXACT [PMID:38548667] is_a: CL:0002204 ! tuft cell is_a: CL:1000296 ! epithelial cell of urethra intersection_of: CL:0002204 ! tuft cell intersection_of: BFO:0000050 UBERON:0002325 ! part of epithelium of urethra relationship: BFO:0000050 UBERON:0002325 ! part of epithelium of urethra relationship: RO:0002215 GO:1904320 ! capable of positive regulation of smooth muscle contraction involved in micturition property_value: terms:contributor https://orcid.org/0009-0000-8480-9277 property_value: terms:date "2025-02-12T14:39:03Z" xsd:dateTime [Term] id: CL:4052045 name: steroidogenic stromal cell of ovary def: "A stromal cell that is part of the ovarian stroma, characterized by its ability to synthesize steroid hormones." [doi:/10.1101/2024.12.15.628550, PMID:36205477] subset: human_subset subset: mouse_subset synonym: "Enpp2− interstitial cell" RELATED [PMID:36205477] synonym: "steroidogenic interstitial stromal cell" BROAD [PMID:36205477] synonym: "steroidogenic stromal cell" BROAD [PMID:36205477] is_a: CL:0002132 ! stromal cell of ovary intersection_of: CL:0000499 ! stromal cell intersection_of: BFO:0000050 UBERON:0006960 ! part of ovary stroma intersection_of: RO:0002215 GO:0120178 ! capable of steroid hormone biosynthetic process relationship: BFO:0000050 UBERON:0006960 ! part of ovary stroma relationship: RO:0002215 GO:0120178 ! capable of steroid hormone biosynthetic process property_value: terms:contributor https://orcid.org/0009-0000-8480-9277 property_value: terms:date "2025-03-05T13:37:44Z" xsd:dateTime [Term] id: CL:4052046 name: early luteal cell def: "A luteal cell that is part of the young, developing corpus luteum. This cell promotes progesterone synthesis, marked by high Parm1 expression in mice (Lan et al., 2024). An early luteal cell is associated with steroidogenesis and cell growth, contributing to early corpus luteum function and maturation." [doi:/10.1101/2024.12.15.628550, PMID:36205477] subset: human_subset subset: mouse_subset synonym: "active corpus luteum cell" EXACT [PMID:36205477] is_a: CL:0000175 ! luteal cell relationship: RO:0002215 GO:0006701 ! capable of progesterone biosynthetic process property_value: terms:contributor https://orcid.org/0009-0000-8480-9277 property_value: terms:date "2025-03-05T16:40:18Z" xsd:dateTime [Term] id: CL:4052047 name: late luteal cell def: "A luteal cell that is part of the older, regressing corpus luteum. This cell exhibits increased expression of genes involved in progesterone metabolism - Akr1c18 in mice (Lan et al., 2024), cell cycle arrest, and apoptosis. A late luteal cell contributes to corpus luteum regression and eventual clearance from the ovary through luteolysis." [doi:/10.1101/2024.12.15.628550, PMID:31803139, PMID:36205477] subset: human_subset subset: mouse_subset synonym: "regressing corpus luteum cell" EXACT [PMID:36205477] is_a: CL:0000175 ! luteal cell relationship: RO:0002215 GO:0006709 ! capable of progesterone catabolic process property_value: terms:contributor https://orcid.org/0009-0000-8480-9277 property_value: terms:date "2025-03-05T16:47:20Z" xsd:dateTime [Term] id: CL:4052048 name: intercalated cell of salivary gland def: "A cuboidal epithelial cell that is part of the intercalated duct of salivary gland. This cell expresses proteins commonly associated with acinar cells and displays calcium signaling characteristics similar to secretory cells, indicating an active role in the secretory process rather than ion reabsorption." [PMID:30855909, PMID:35799078, PMID:36726292, PMID:37724716] subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "Id cell" RELATED [PMID:35799078] synonym: "intercalated duct cell" BROAD [PMID:37724716] synonym: "salivary intercalated duct cells" EXACT [PMID:37724716] is_a: CL:0000068 ! duct epithelial cell is_a: CL:1001596 ! salivary gland glandular cell relationship: BFO:0000050 UBERON:0014727 ! part of intercalated duct of salivary gland relationship: BFO:0000050 UBERON:0015766 ! part of epithelium of duct of salivary gland property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/2d-ftu/mouth-parotid-gland/v1.0/assets/2d-ftu-mouth-parotid-gland.png" xsd:string {terms:licence="http://creativecommons.org/licenses/by/4.0/", xref="doi:10.48539/HBM466.TLJQ.498"} property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/2d-ftu/mouth-sublingual-gland/v1.0/assets/2d-ftu-mouth-sublingual-gland.png" xsd:string {terms:licence="http://creativecommons.org/licenses/by/4.0/", xref="doi:10.48539/HBM664.JPSV.649"} property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/2d-ftu/mouth-submandibular-gland/v1.0/assets/2d-ftu-mouth-submandibular-gland.png" xsd:string {terms:licence="http://creativecommons.org/licenses/by/4.0/", xref="doi:10.48539/HBM632.XNRG.877"} property_value: RO:0002175 NCBITaxon:9606 property_value: terms:contributor https://orcid.org/0000-0003-4389-9821 property_value: terms:contributor https://orcid.org/0009-0000-8480-9277 property_value: terms:date "2024-09-11T09:55:55Z" xsd:dateTime [Term] id: CL:4052049 name: striated cell of salivary gland def: "An columnar/cuboidal epithelial cell that is part of the striated duct of salivary gland, characterized by basal striations formed by infoldings of the plasma membrane. This cell play a crucial role in modifying the electrolyte composition and concentration of saliva through active ion transport, particularly the absorption of sodium and secretion of potassium." [PMID:30855909, PMID:34147989, PMID:36726292] subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "SD cells" BROAD [PMID:11590591] synonym: "striated duct cells" BROAD [PMID:11590591] is_a: CL:0000068 ! duct epithelial cell is_a: CL:0000075 ! columnar/cuboidal epithelial cell is_a: CL:1001596 ! salivary gland glandular cell intersection_of: CL:0000075 ! columnar/cuboidal epithelial cell intersection_of: BFO:0000050 UBERON:0014729 ! part of striated duct of salivary gland relationship: BFO:0000050 UBERON:0014729 ! part of striated duct of salivary gland relationship: BFO:0000050 UBERON:0015766 ! part of epithelium of duct of salivary gland relationship: RO:0002215 GO:0036376 ! capable of sodium ion export across plasma membrane relationship: RO:0002215 GO:1990573 ! capable of potassium ion import across plasma membrane property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/2d-ftu/mouth-parotid-gland/v1.0/assets/2d-ftu-mouth-parotid-gland.png" xsd:string {terms:licence="http://creativecommons.org/licenses/by/4.0/", xref="doi:10.48539/HBM466.TLJQ.498"} property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/2d-ftu/mouth-submandibular-gland/v1.0/assets/2d-ftu-mouth-submandibular-gland.png" xsd:string {terms:licence="http://creativecommons.org/licenses/by/4.0/", xref="doi:10.48539/HBM632.XNRG.877"} property_value: RO:0002175 NCBITaxon:9606 property_value: terms:contributor https://orcid.org/0000-0003-4389-9821 property_value: terms:contributor https://orcid.org/0009-0000-8480-9277 property_value: terms:date "2024-09-11T10:00:25Z" xsd:dateTime [Term] id: CL:4052050 name: luminal epithelial cell of endometrium def: "An epithelial cell that is part of an endometrium luminal epithelium." [PMID:36273006] subset: human_subset subset: mouse_subset synonym: "endometrial luminal epithelial cell" EXACT [PMID:31317179] is_a: CL:0002149 ! epithelial cell of uterus intersection_of: CL:0000066 ! epithelial cell intersection_of: BFO:0000050 UBERON:0011949 ! part of endometrium luminal epithelium relationship: BFO:0000050 UBERON:0011949 ! part of endometrium luminal epithelium property_value: terms:contributor https://orcid.org/0009-0000-8480-9277 property_value: terms:date "2025-03-13T13:46:13Z" xsd:dateTime [Term] id: CL:4052051 name: uterine natural killer cell 1, human def: "​​A uterine natural killer subset that is present in the endometrial lining during the non-pregnant state (Garcia-Alonso et al., 2021) and in the decidua during pregnancy (Vento-Tormo et al., 2018). It expresses the uterine resident marker CD49a and is distinguished from uNK2 and uNK3 by CD39 expression and the absence of CD103 (Whettlock et al., 2022) and CD160 (Marečková et al., 2024). It also expresses higher levels of killer-cell immunoglobulin-like receptors (KIRs) and leukocyte immunoglobulin-like receptor B1 (LILRB1), which facilitate interaction with human leukocyte antigens (HLAs) on extravillous trophoblast cells, promoting immune tolerance and implantation. Enriched in the endometrium post-ovulation (Marečková et al., 2024) and prominent in early pregnancy (Whettlock et al., 2022), uNK1 regulates trophoblast invasion and spiral artery remodeling (Zhang & Wei, 2021)." [PMID:30429548, PMID:34512661, PMID:34857954, PMID:35784314, PMID:39198675] subset: human_subset synonym: "decidual natural killer cell 1" NARROW [PMID:30429548] synonym: "uNK1" RELATED OMO:0003000 [PMID:39198675] is_a: CL:4052028 ! uterine natural killer cell intersection_of: CL:4052028 ! uterine natural killer cell intersection_of: CL:4030046 PR:O95971 ! lacks_plasma_membrane_part CD160 antigen (human) intersection_of: CL:4030046 PR:P38570 ! lacks_plasma_membrane_part integrin alpha-E (human) intersection_of: RO:0002104 PR:P49961 ! has plasma membrane part ectonucleoside triphosphate diphosphohydrolase 1 (human) intersection_of: RO:0002104 PR:P56199 ! has plasma membrane part integrin alpha-1 (human) intersection_of: RO:0002162 NCBITaxon:9606 ! in taxon Homo sapiens relationship: CL:4030046 PR:O95971 ! lacks_plasma_membrane_part CD160 antigen (human) relationship: CL:4030046 PR:P38570 ! lacks_plasma_membrane_part integrin alpha-E (human) relationship: RO:0002104 PR:P49961 ! has plasma membrane part ectonucleoside triphosphate diphosphohydrolase 1 (human) relationship: RO:0002104 PR:P56199 ! has plasma membrane part integrin alpha-1 (human) property_value: terms:contributor https://orcid.org/0009-0000-8480-9277 property_value: terms:date "2025-03-14T10:48:38Z" xsd:dateTime [Term] id: CL:4052052 name: uterine natural killer cell 2, human def: "A uterine natural killer subset that is present in the endometrial lining during the non-pregnant state (Garcia-Alonso et al., 2021) and in the decidua during pregnancy (Vento-Tormo et al., 2018), peaking in the first trimester. It expresses the uterine resident marker CD49a and is distinguished from uNK1 and uNK3 by the absence of CD39, CD103 (Whettlock et al., 2022), and CD160 (Marečková et al., 2024), with ITGB2 serving as a defining marker (Vento-Tormo et al., 2018). Functionally, it produces more cytokines upon stimulation than uNK1, suggesting a role in immune defense, and secretes XCL1 chemokines, facilitating interactions with maternal dendritic cells and fetal extravillous trophoblasts (Vento-Tormo et al., 2018)." [PMID:30429548, PMID:34857954, PMID:35784314, PMID:39198675] subset: human_subset synonym: "decidual natural killer cell 2" NARROW [PMID:30429548] synonym: "uNK2" RELATED OMO:0003000 [PMID:39198675] is_a: CL:4052028 ! uterine natural killer cell intersection_of: CL:4052028 ! uterine natural killer cell intersection_of: CL:4030046 PR:O95971 ! lacks_plasma_membrane_part CD160 antigen (human) intersection_of: CL:4030046 PR:P38570 ! lacks_plasma_membrane_part integrin alpha-E (human) intersection_of: CL:4030046 PR:P49961 ! lacks_plasma_membrane_part ectonucleoside triphosphate diphosphohydrolase 1 (human) intersection_of: RO:0002104 PR:P56199 ! has plasma membrane part integrin alpha-1 (human) intersection_of: RO:0002162 NCBITaxon:9606 ! in taxon Homo sapiens relationship: CL:4030046 PR:O95971 ! lacks_plasma_membrane_part CD160 antigen (human) relationship: CL:4030046 PR:P38570 ! lacks_plasma_membrane_part integrin alpha-E (human) relationship: CL:4030046 PR:P49961 ! lacks_plasma_membrane_part ectonucleoside triphosphate diphosphohydrolase 1 (human) relationship: RO:0002104 PR:P56199 ! has plasma membrane part integrin alpha-1 (human) property_value: terms:contributor https://orcid.org/0009-0000-8480-9277 property_value: terms:date "2025-03-14T14:31:03Z" xsd:dateTime [Term] id: CL:4052053 name: uterine natural killer cell 3, human def: "A uterine natural killer subset found in the endometrial lining during the non-pregnant state (Garcia-Alonso et al., 2021) and in the decidua during pregnancy (Vento-Tormo et al., 2018), becoming the dominant uNK subset late in pregnancy. It expresses the uterine resident marker CD49a and is distinguished from uNK1 and uNK2 by CD160 (Marečková et al., 2024) and CD103 expression, the absence of CD39, and low KIR levels (Whettlock et al., 2022). Resembling intraepithelial ILC1 cells, uNK3 primarily supports uterine immune defense (Huhn et al., 2020) and indirectly influences trophoblast behavior through chemokine secretion, such as CCL5 (Vento-Tormo et al., 2018)." [PMID:30429548, PMID:31959757, PMID:34857954, PMID:35784314, PMID:39198675] subset: human_subset synonym: "decidual natural killer cell 3" NARROW [PMID:30429548] synonym: "uNK3" RELATED OMO:0003000 [PMID:39198675] is_a: CL:4052028 ! uterine natural killer cell intersection_of: CL:4052028 ! uterine natural killer cell intersection_of: CL:4030046 PR:P49961 ! lacks_plasma_membrane_part ectonucleoside triphosphate diphosphohydrolase 1 (human) intersection_of: RO:0002104 PR:O95971 ! has plasma membrane part CD160 antigen (human) intersection_of: RO:0002104 PR:P38570 ! has plasma membrane part integrin alpha-E (human) intersection_of: RO:0002104 PR:P56199 ! has plasma membrane part integrin alpha-1 (human) intersection_of: RO:0002162 NCBITaxon:9606 ! in taxon Homo sapiens relationship: CL:4030046 PR:P49961 ! lacks_plasma_membrane_part ectonucleoside triphosphate diphosphohydrolase 1 (human) relationship: RO:0002104 PR:O95971 ! has plasma membrane part CD160 antigen (human) relationship: RO:0002104 PR:P38570 ! has plasma membrane part integrin alpha-E (human) relationship: RO:0002104 PR:P56199 ! has plasma membrane part integrin alpha-1 (human) property_value: terms:contributor https://orcid.org/0009-0000-8480-9277 property_value: terms:date "2025-03-14T16:15:39Z" xsd:dateTime [Term] id: CL:4052055 name: mature NK T cell, human def: "A mature NK T cell that can be identified by the expression of CD56 in humans." [PMID:30714682, PMID:30875134] subset: human_subset synonym: "mature natural killer T cell, human" EXACT [https://orcid.org/0009-0000-8480-9277] synonym: "mature natural killer T lymphocyte, human" EXACT [https://orcid.org/0009-0000-8480-9277] synonym: "mature natural killer T-lymphocyte, human" EXACT [https://orcid.org/0009-0000-8480-9277] synonym: "mature NK T lymphocyte, human" EXACT [https://orcid.org/0009-0000-8480-9277] synonym: "mature NK T-cell, human" EXACT [https://orcid.org/0009-0000-8480-9277] synonym: "mature NK T-lymphocyte, human" EXACT [https://orcid.org/0009-0000-8480-9277] synonym: "mature NKT cell, human" EXACT [https://orcid.org/0009-0000-8480-9277] is_a: CL:0000814 ! mature NK T cell intersection_of: CL:0000814 ! mature NK T cell intersection_of: RO:0002104 PR:P13591 ! has plasma membrane part neural cell adhesion molecule 1 (human) intersection_of: RO:0002162 NCBITaxon:9606 ! in taxon Homo sapiens relationship: RO:0002104 PR:P13591 ! has plasma membrane part neural cell adhesion molecule 1 (human) property_value: terms:contributor https://orcid.org/0000-0001-5742-4697 property_value: terms:contributor https://orcid.org/0009-0000-8480-9277 property_value: terms:date "2025-03-26T11:56:38Z" xsd:dateTime [Term] id: CL:4052058 name: Merkel cell of epidermis def: "A Merkel cell found mainly in the basal layer of the epidermis and the outer root sheath of hair follicles, particularly concentrated in areas with high tactile acuity, such as touch domes, hair follicles, and fingertips." [PMID:19834574, PMID:2274847, PMID:30415995, Wikipedia:Merkel_cell] subset: human_subset subset: mouse_subset synonym: "epdiermal Merkel cell" EXACT [PMID:6207057] is_a: CL:0000242 ! Merkel cell is_a: CL:0000362 ! epidermal cell intersection_of: CL:0000242 ! Merkel cell intersection_of: BFO:0000050 UBERON:0001003 ! part of skin epidermis relationship: BFO:0000050 UBERON:0001003 ! part of skin epidermis property_value: terms:contributor https://orcid.org/0009-0000-8480-9277 property_value: terms:date "2025-06-11T10:01:40Z" xsd:dateTime [Term] id: CL:4052060 name: spinous cell def: "A differentiating keratinocyte found in the epidermis and oral epithelium, located in the stratum spinosum, characterized by a spiny appearance due to abundant intercellular desmosomal junctions." [PMID:34283481, wikipedia:Spinous_cell] subset: human_subset subset: mouse_subset synonym: "prickle cell" EXACT [wikipedia:Spinous_cell] is_a: CL:0000312 ! keratinocyte relationship: BFO:0000051 GO:0030057 ! has part desmosome relationship: RO:0000053 PATO:0001365 ! has characteristic spiny property_value: terms:contributor https://orcid.org/0009-0000-8480-9277 property_value: terms:date "2025-07-02T12:21:06Z" xsd:dateTime [Term] id: CL:4052061 name: epidermal keratinocyte def: "A keratinocyte of the skin epidermis that synthesizes keratin and undergoes successive stages of differentiation as it migrates from the basal layer to the cornified (stratum corneum) layer. These differentiation stages include the basal, spinous (prickle), and granular cell layers. This cell is central to epidermal homeostasis, mediating wound healing, immune modulation, including the secretion of cytokines and chemokines that recruit neutrophils (Simmons and Gallo, 2024), and intercellular communication with adjacent melanocytes (Marrapodi and Bellei, 2024)." [MESH:D015603, PMID:15749908, PMID:19727116, PMID:38473275, PMID:39115524, wikipedia:Keratinocyte] comment: Keratinocytes are reportedly CDw210a(IL-10RA)-negative , CDw210b(IL-10RB)-positive, IL22Ra1-positive, Human keratinocytes are reportedly capable of secreting BD-2, BD-3, hCAP-18, CXCL1, CXCL5, CXCL8, elafin, MMP-3, NGAL, PDGF-A, S100A7, S100A8, and S100A9. Transcription factors: STAT3-positive. {xref="PMID:15749908", xref="PMID:19727116"} subset: human_subset subset: mouse_subset synonym: "keratincyte of epidermis" EXACT [] synonym: "skin keratinocyte" EXACT [PMID:39185948] is_a: CL:0000312 ! keratinocyte is_a: CL:0000362 ! epidermal cell intersection_of: CL:0000312 ! keratinocyte intersection_of: BFO:0000050 UBERON:0001003 ! part of skin epidermis relationship: BFO:0000050 UBERON:0001003 ! part of skin epidermis relationship: RO:0002215 GO:0090023 ! capable of positive regulation of neutrophil chemotaxis property_value: terms:contributor https://orcid.org/0009-0000-8480-9277 property_value: terms:date "2025-07-02T12:32:13Z" xsd:dateTime [Term] id: CL:4052062 name: onychofibroblast def: "A specialized fibroblast located in the onychodermis that play a key role in nail growth and regeneration by interacting with LGR6-positive nail matrix keratinocytes. These interactions mediate essential signaling pathways, particularly WNT signaling, which is critical for epithelial–mesenchymal communication and coordinated nail development. In humans, this cell expresses key markers, including RSPO4, MSX1, WIF1, and BMP5, all involved in nail differentiation." [PMID:34099859, PMID:35853486, PMID:39044464] subset: human_subset subset: mouse_subset is_a: CL:0002620 ! skin fibroblast relationship: BFO:0000050 UBERON:0001705 ! part of nail property_value: terms:contributor https://orcid.org/0009-0000-8480-9277 property_value: terms:date "2025-07-22T14:35:00Z" xsd:dateTime [Term] id: CL:4052063 name: nail bed keratinocyte def: "A keratinocyte that resides in the nail bed, responsible for tightly attaching the nail plate to the underlying dermis. Unlike typical epidermal keratinocytes, it exhibits limited proliferation, undergoes modified differentiation that skips the granular layer and conventional cornification, and primarily ensures adhesion and maintenance of the nail plate. In humans, this cell expresses characteristic markers, including the protease inhibitor SPINK6 and the differentiation-associated protein KRT16." [PMID:10651700, PMID:30969555, PMID:33799809, PMID:34099859, PMID:39044464] subset: human_subset subset: mouse_subset is_a: CL:4052061 ! epidermal keratinocyte relationship: BFO:0000050 UBERON:0005273 ! part of nail bed property_value: terms:contributor https://orcid.org/0009-0000-8480-9277 property_value: terms:date "2024-07-22T15:30:00Z" xsd:dateTime [Term] id: CL:4052064 name: nail matrix keratinocyte def: "A keratinocyte that is part of the nail matrix epithelium, distinguished by its high proliferative capacity and its role in nail plate formation via onychokeratinization, a differentiation process that uniquely bypasses the formation of a granular layer, resulting in the production of hard, compact keratin. Unlike skin epidermal keratinocytes, this cell expresses a distinctive mix of hard (hair-type) and select epidermal keratins (Kitahara and Ogawa, 1993). In humans, LGR6 and WNT6 are enriched in the basal compartment, with LGR6 marking nail stem cells in both mice and humans, and exhibiting strong expression in the human proximal nail matrix (Kim et al., 2021)." [PMID:28098391, PMID:30969555, PMID:34099859, PMID:39044464, PMID:7679137] subset: human_subset subset: mouse_subset synonym: "nail matrix epithelial keratinocyte" EXACT [PMID:39044464] is_a: CL:4052061 ! epidermal keratinocyte intersection_of: CL:0000312 ! keratinocyte intersection_of: BFO:0000050 UBERON:0002283 ! part of nail matrix relationship: BFO:0000050 UBERON:0002283 ! part of nail matrix property_value: terms:contributor https://orcid.org/0009-0000-8480-9277 property_value: terms:date "2025-07-22T15:30:00Z" xsd:dateTime [Term] id: CL:4052065 name: serous acinar cell of salivary gland def: "An acinar cell of the salivary gland, characterized by a pyramidal or triangular shape with a spherical nucleus and abundant eosinophilic zymogen granules. This cell secretes watery, enzyme‐rich fluid containing α-amylase, proline-rich proteins, and secretory immunoglobulins for starch digestion and antimicrobial defence. In humans and mice, serous acinar cell predominates in the parotid gland and to a lesser extent in the submandibular gland, where it exists alongside mucous acinar cells (Maruyama et al., 2019)." [PMID:29383862, PMID:32829674, PMID:35343828] subset: human_subset subset: mouse_subset is_a: CL:0000313 ! serous secreting cell is_a: CL:0002623 ! acinar cell of salivary gland intersection_of: CL:0000313 ! serous secreting cell intersection_of: CL:0002623 ! acinar cell of salivary gland intersection_of: BFO:0000050 UBERON:0013232 ! part of serous acinus relationship: BFO:0000050 UBERON:0013232 ! part of serous acinus relationship: BFO:0000051 GO:0042588 ! has part zymogen granule relationship: RO:0002215 GO:0005983 ! capable of starch catabolic process property_value: terms:contributor https://orcid.org/0009-0000-8480-9277 property_value: terms:date "2025-08-05T15:24:46Z" xsd:dateTime [Term] id: CL:4052066 name: mucous acinar cell of salivary gland def: "An acinar cell of the salivary gland, responsible for producing a viscous, mucin‐rich solution, thereby facilitating lubrication and protection of the oral mucosa. This cell is characterized by an elongated shape, clear cytoplasm filled with mucin granules, and a basally compressed nucleus (Barrows et al., 2020). In humans and mice, the mucous acinar cell predominates in the sublingual gland and minor salivary glands, while also being present in mixed glands such as the submandibular gland, where it coexists with serous acinar cells (Maruyama et al., 2019)." [PMID:29383862, PMID:32829674, PMID:35343828] subset: human_subset subset: mouse_subset is_a: CL:0000319 ! mucus secreting cell is_a: CL:0002623 ! acinar cell of salivary gland intersection_of: CL:0002623 ! acinar cell of salivary gland intersection_of: BFO:0000050 UBERON:0014717 ! part of mucous acinus relationship: BFO:0000050 UBERON:0014717 ! part of mucous acinus relationship: BFO:0000051 GO:0098594 ! has part mucin granule property_value: terms:contributor https://orcid.org/0009-0000-8480-9277 property_value: terms:date "2025-08-05T15:33:46Z" xsd:dateTime [Term] id: CL:4052067 name: seromucous acinar cell of salivary gland def: "An acinar cell of the salivary gland, with a hybrid seromucous phenotype, co-expressing serous and mucous markers and producing a mixed secretion of enzymes-containing serous fluid and mucins essential for lubrication, digestion, and antimicrobial defense. Predominant in the submandibular glands of humans and mice, its differentiation and secretory gene expression are regulated by FGFR2b–MAPK signaling, driven by paracrine FGF7 from adjacent myoepithelial cells, which provides a key niche signal for seromucous identity." [PMID:29383862, PMID:35343828, PMID:36726292] subset: human_subset subset: mouse_subset is_a: CL:0000159 ! seromucus secreting cell is_a: CL:0002623 ! acinar cell of salivary gland property_value: terms:contributor https://orcid.org/0009-0000-8480-9277 property_value: terms:date "2025-08-06T11:26:37Z" xsd:dateTime [Term] id: CL:4052069 name: excretory duct cell of salivary gland def: "A duct epithelial cell that is part of the excretory duct of the salivary gland, which transports saliva from the intralobular ductal system to the oral cavity. While primarily serving as a conduit, this cell may play a role in the saliva modification, contributing to its hypotonicity. In humans, this cell has a pseudostratified columnar shape." [doi:/10.1007/978-3-030-35784-9_2, doi:10.5772/intechopen.75538, PMID:28192873, PMID:31194408] subset: human_subset subset: mouse_subset synonym: "salivary excretory duct cell" EXACT [doi:/10.1007/978-3-030-35784-9_2] is_a: CL:0000068 ! duct epithelial cell is_a: CL:1001596 ! salivary gland glandular cell relationship: BFO:0000050 UBERON:0035049 ! part of excretory duct of salivary gland property_value: terms:contributor https://orcid.org/0009-0000-8480-9277 property_value: terms:date "2025-08-08T11:20:00Z" xsd:dateTime [Term] id: CL:4052070 name: dual-feature fallopian tube progenitor cell def: "A bipotent progenitor cell within the human fallopian tube epithelium, characterized by the concurrent expression of epithelial (e.g., EpCAM/CD326) and endothelial (e.g., PECAM1/CD31) markers at both the cell surface and transcript levels. This cell has the capacity to differentiate into ciliated and secretory epithelial cells, as well as potentially endothelial/stromal lineages. Positioned at the apex of lineage bifurcation, the cell exhibits stem-like and endothelial features, representing an intermediate developmental state between undifferentiated progenitors and lineage-committed epithelial cells." [PMID:40475517] subset: human_subset synonym: "non-ciliated secretory epithelial cell 2-1 (NCSE2-1 cells)" NARROW [PMID:35320732] synonym: "non-ciliated secretory epithelial cell 2-2 (NCSE2-2 cells)" NARROW [PMID:35320732] synonym: "unclassified fallopian tube progenitor" EXACT [PMID:40475517] is_a: CL:0011026 ! progenitor cell relationship: BFO:0000050 UBERON:8600124 ! part of fallopian tube epithelium relationship: RO:0002162 NCBITaxon:9606 ! in taxon Homo sapiens property_value: terms:contributor https://orcid.org/0009-0000-8480-9277 property_value: terms:date "2025-08-12T16:05:47Z" xsd:dateTime [Term] id: CL:4052071 name: quiescent fibroblast def: "A fibroblast in a quiescent state, characterized by a smaller, spindle-shaped morphology with a relatively small cytoplasm, modest rough endoplasmic reticulum and condensed chromatin. Despite low proliferation and contractility, it maintains high metabolic activity for extracellular-matrix homeostasis through continuous matrix protein turnover and mechanosensitive signaling. This cell can rapidly differentiate into contractile myofibroblasts under injury or inflammatory cues to drive tissue repair." [doi:/10.1038/s41427-020-0226-7, PMID:21049082, PMID:35701396, PMID:40538750, Wikipedia:Fibroblast] comment: Historically, quiescent fibroblasts in uninjured tissues were often called “fibrocytes”, but this distinction faded over time, and the term “fibroblast” came to be used universally, regardless of activation state. Fibrocyte has been repurposed to describe a distinct population of bone marrow–derived, circulating cells that home to sites of injury and contribute to tissue repair and fibrosis. {xref="PMID: 35701396"} subset: human_subset subset: mouse_subset synonym: "inactive fibroblast" EXACT [PMID:22529592] is_a: CL:0000057 ! fibroblast property_value: terms:contributor https://orcid.org/0009-0000-8480-9277 property_value: terms:date "2025-08-13T15:42:37Z" xsd:dateTime [Term] id: CL:4052108 name: IgD-negative class switched memory B cell def: "A class switched memory B cell that lacks IgD on the cell surface." [PMID:20839340, PMID:32741082, PMID:36617261, PMID:37254600] subset: human_subset subset: mouse_subset is_a: CL:0000972 ! class switched memory B cell is_a: CL:0001053 ! IgD-negative memory B cell intersection_of: CL:0000972 ! class switched memory B cell intersection_of: CL:4030046 GO:0071738 ! lacks_plasma_membrane_part IgD immunoglobulin complex property_value: terms:contributor https://orcid.org/0009-0000-8480-9277 property_value: terms:date "2025-12-08T10:33:49Z" xsd:dateTime [Term] id: CL:4070010 name: gastric mill neuron def: "A motor neuron that moves the medial tooth forward" [doi:10.1007/978-3-642-71516-7_2] synonym: "GM" EXACT [] is_a: CL:0000100 ! motor neuron relationship: RO:0002100 UBERON:8910001 ! has soma location stomatogastric ganglion property_value: RO:0002175 NCBITaxon:6712 property_value: RO:0002175 NCBITaxon:6752 property_value: terms:contributor https://orcid.org/0000-0002-1909-7004 [Term] id: CL:4070011 name: lateral gastric neuron def: "A motor neuron that closes the lateral teeth." [doi:10.1007/978-3-642-71516-7_2] synonym: "LG" EXACT [] is_a: CL:0000100 ! motor neuron relationship: RO:0002100 UBERON:8910001 ! has soma location stomatogastric ganglion property_value: RO:0002175 NCBITaxon:6712 property_value: RO:0002175 NCBITaxon:6752 property_value: terms:contributor https://orcid.org/0000-0002-1909-7004 [Term] id: CL:4070012 name: inferior cardiac neuron def: "A motor neuron that controls ventral stomach grooves leading to pyloric filter." [doi:10.1007/978-3-642-71516-7_2] synonym: "IC" EXACT [] is_a: CL:0000100 ! motor neuron relationship: RO:0002100 UBERON:8910001 ! has soma location stomatogastric ganglion property_value: RO:0002175 NCBITaxon:6712 property_value: RO:0002175 NCBITaxon:6752 property_value: terms:contributor https://orcid.org/0000-0002-1909-7004 [Term] id: CL:4070013 name: ventricular dilator motor neuron def: "A motor neuron that controls ventral stomach grooves leading to pyloric filter." [doi:10.1007/978-3-642-71516-7_2] synonym: "VD" EXACT [] is_a: CL:0000100 ! motor neuron relationship: RO:0002100 UBERON:8910001 ! has soma location stomatogastric ganglion property_value: RO:0002175 NCBITaxon:6712 property_value: RO:0002175 NCBITaxon:6752 property_value: terms:contributor https://orcid.org/0000-0002-1909-7004 [Term] id: CL:4070014 name: pyloric motor neuron def: "A motor neuron that controls pyloric filter movements; innervates the pyloric muscle." [doi:10.1007/978-3-642-71516-7_2, PMID:6296329] synonym: "PY" EXACT [] is_a: CL:0000100 ! motor neuron relationship: RO:0002100 UBERON:8910001 ! has soma location stomatogastric ganglion property_value: RO:0002175 NCBITaxon:6712 property_value: RO:0002175 NCBITaxon:6752 property_value: terms:contributor https://orcid.org/0000-0002-1909-7004 [Term] id: CL:4070015 name: pyloric dilator neuron def: "A motor neuron that controls the cardiopyloric valve." [doi:10.1007/978-3-642-71516-7_2, PMID:6296329] synonym: "PD" EXACT [] is_a: CL:0000100 ! motor neuron relationship: RO:0002100 UBERON:8910001 ! has soma location stomatogastric ganglion property_value: RO:0002175 NCBITaxon:6712 property_value: RO:0002175 NCBITaxon:6752 property_value: terms:contributor https://orcid.org/0000-0002-1909-7004 [Term] id: CL:4070016 name: anterior burster neuron def: "Pyloric pacemaker neuron that provides feedback to commissural ganglia (CoG) neurons." [doi:10.1007/978-3-642-71516-7_2, PMID:6296329] synonym: "AB" EXACT [] is_a: CL:0000099 ! interneuron relationship: RO:0002100 UBERON:8910001 ! has soma location stomatogastric ganglion property_value: RO:0002175 NCBITaxon:6712 property_value: RO:0002175 NCBITaxon:6752 property_value: terms:contributor https://orcid.org/0000-0002-1909-7004 [Term] id: CL:4070017 name: lateral pyloric motor neuron def: "A motor neuron that controls pyloric filter movements; innervates the lateral pyloric muscle." [doi:10.1007/978-3-642-71516-7_2, PMID:6296329] synonym: "LP" EXACT [] is_a: CL:0000100 ! motor neuron relationship: RO:0002100 UBERON:8910001 ! has soma location stomatogastric ganglion property_value: RO:0002175 NCBITaxon:6712 property_value: RO:0002175 NCBITaxon:6752 property_value: terms:contributor https://orcid.org/0000-0002-1909-7004 [Term] id: CL:4072001 name: newly formed oligodendrocyte def: "A post-mitotic oligodendrocyte that has exited the cell cycle and begun early stage differentiation. The cell begins to acquire oligodendrocyte-like characteristics but has not yet initiated myelination. In mice, NFOL is marked by the expression of Tcf7l2 and Cemip2 (also known as Tmem2), among other early myelin-related genes. These markers highlight cells transitioning from a precursor to a more differentiated, pre-myelinating state." [PMID:27284195, PMID:39233334] subset: human_subset subset: mouse_subset synonym: "NFOL" RELATED OMO:0003000 [PMID:27284195] is_a: CL:0000123 ! neuron associated cell (sensu Vertebrata) is_a: CL:0000128 ! oligodendrocyte relationship: RO:0002207 CL:4023059 ! directly develops from committed oligodendrocyte precursor property_value: terms:contributor https://orcid.org/0000-0002-5507-2103 [Term] id: CL:4072002 name: myelin-forming oligodendrocyte def: "A postmitotic and differentiated oligodendrocyte derived from a oligodendrocyte progenitor cell. A myelin-forming oligodendrocyte begins the expression of myelin genes and actively engages in the myelination process. In mice and humans, it is characterized by the upregulation of the key myelin-associated markers Mbp and Opalin. Additionally, Ctps (CTP synthase) shows peak expression at this stage, suggesting a heightened demand for nucleotide biosynthesis during membrane expansion and myelin production." [PMID:27284195, PMID:30837646, PMID:39233334, PMID:9473608] subset: human_subset subset: mouse_subset synonym: "MFOL" RELATED OMO:0003000 [PMID:39233334] is_a: CL:0000128 ! oligodendrocyte is_a: UBERON:0004121 ! ectoderm-derived structure relationship: RO:0002207 CL:4072001 ! directly develops from newly formed oligodendrocyte relationship: RO:0002215 GO:0032289 ! capable of central nervous system myelin formation property_value: terms:contributor https://orcid.org/0000-0002-5507-2103 [Term] id: CL:4072003 name: mature myelinating oligodendrocyte def: "A post-mitotic oligodendrocyte derived from a myelin-forming oligodendrocyte (MFOL). A mature Myelinating Oligodendrocyte is a fully differentiated cell that is actively engaged in myelination. In addition to high expression of canonical myelin genes (e.g., Mbp, Plp1, Mog), a MOL can be distinguished by the expression of stage-enriched genes Grm3, Klk6, Ptgds, Anxa5, and Hopx in mice. These markers reflect the functional specialization of a mature oligodendrocyte, including roles in signalling, lipid metabolism, and myelin maintenance." [PMID:27284195, PMID:33203872] subset: human_subset subset: mouse_subset synonym: "MOL" RELATED OMO:0003000 [PMID:27284195] is_a: CL:0000128 ! oligodendrocyte is_a: UBERON:0004121 ! ectoderm-derived structure relationship: RO:0002207 CL:4072002 ! directly develops from myelin-forming oligodendrocyte relationship: RO:0002215 GO:0032289 ! capable of central nervous system myelin formation property_value: terms:contributor https://orcid.org/0000-0002-5507-2103 [Term] id: CL:4072005 name: A8 dopaminergic neuron def: "A type of midbrain dopaminergic neuron localized in the retrorubral field which projects to limbic and cortical regions involved in emotion, motivation, and reward." [PMID:32869307, PMID:33756109, PMID:34532720, PMID:8514911] subset: human_subset subset: mouse_subset synonym: "A8 dopamine neuron" EXACT [PMID:33756109] is_a: BFO:0000002 is_a: CL:2000097 ! midbrain dopaminergic neuron relationship: RO:0002100 UBERON:0011172 ! has soma location retrorubral area of midbrain reticular nucleus property_value: terms:date "2025-05-02T08:37:36Z" xsd:dateTime [Term] id: CL:4072006 name: A9 dopaminergic neuron def: "A type of dopaminergic neuron in the substantia nigra involved in motor control and particularly vulnerable in Parkinson’s disease. In mice, it is notable for its heterogeneous co-release of dopamine with either glutamate or GABA. It releases GABA through alternative synthesis pathways or reuptake mechanisms independent of GAD expression." [PMID:23603197, PMID:24843012, PMID:26430123, PMID:32869307, PMID:38092916, PMID:39961377] subset: human_subset subset: mouse_subset synonym: "A9 nigral dopamine neuron" EXACT [PMID:20049900] synonym: "substantia nigra dopaminergic neuron" EXACT [PMID:31704946] is_a: CL:0008060 ! GABA-Glut neuron is_a: CL:4042025 ! substantia nigra dopaminergic neuron property_value: terms:date "2025-05-02T09:59:34Z" xsd:dateTime [Term] id: CL:4072007 name: A10 dopaminergic neuron def: "A type of dopaminergic neuron found in the ventral tegmental area that is involved in reward processes, motivation and addiction." [PMID:23603197, PMID:3107759, PMID:32869307] subset: human_subset subset: mouse_subset synonym: "A10 VTA Dopaminergic Neuron" EXACT [PMID:3107759] is_a: BFO:0000002 is_a: CL:2000097 ! midbrain dopaminergic neuron relationship: RO:0002100 UBERON:0002691 ! has soma location ventral tegmental area property_value: terms:date "2025-05-02T10:13:27Z" xsd:dateTime [Term] id: CL:4072008 name: A11 dopaminergic neuron def: "A type of hypothalamic dopaminergic neuron found in the posterior hypothalamus, projecting to the spinal cord where it modulates pain, motor activity (Koblinger et al., 2014), and somatosensory processing (Zhang et a., 2023)." [PMID:25343491, PMID:37522391, PMID:8978475] subset: human_subset subset: mouse_subset is_a: CL:0000700 ! dopaminergic neuron is_a: CL:0012001 ! neuron of the forebrain relationship: RO:0002100 UBERON:0002770 ! has soma location posterior hypothalamic region property_value: terms:date "2025-05-02T10:33:56Z" xsd:dateTime [Term] id: CL:4072009 name: A12 dopaminergic neuron def: "A type of dopaminergic neuron found in the arcuate hypothalamic nucleus, involved in neuroendocrine regulation, metabolic homeostasis and prolactin secretion." [PMID:39919032] subset: human_subset subset: mouse_subset synonym: "hypothalamic arcuate nucleus dopaminergic neuron" EXACT [PMID:39919032] is_a: CL:0000700 ! dopaminergic neuron is_a: CL:0012001 ! neuron of the forebrain relationship: RO:0002100 UBERON:0001932 ! has soma location arcuate nucleus of hypothalamus property_value: terms:date "2025-05-02T10:43:50Z" xsd:dateTime [Term] id: CL:4072010 name: A13 dopaminergic neuron def: "A type of dopaminergic neuron located in the rostro-medial part of the zona incerta. It is involved in nociception and prehensile movement." [PMID:33318433, PMID:37816347] subset: human_subset subset: mouse_subset is_a: CL:0000700 ! dopaminergic neuron is_a: CL:0012001 ! neuron of the forebrain relationship: RO:0002100 UBERON:0036007 ! has soma location A13 dopaminergic cell group property_value: terms:date "2025-05-02T14:46:33Z" xsd:dateTime [Term] id: CL:4072011 name: A14 dopaminergic neuron def: "A type of dopaminergic neuron located in the periventricular nucleus of the hypothalamus and projecting to the lateral septum and the median eminence. It is contributing to neuroendocrine functions, locomotion and stress regulation." [PMID:10465451, PMID:19210380, PMID:33257725, PMID:36209152] subset: human_subset subset: mouse_subset is_a: CL:0000700 ! dopaminergic neuron is_a: CL:2000029 ! central nervous system neuron relationship: RO:0002100 UBERON:0002322 ! has soma location periventricular nucleus property_value: terms:date "2025-05-06T12:46:22Z" xsd:dateTime [Term] id: CL:4072012 name: A15 dopaminergic neuron def: "A type of dopaminergic neuron located in the preoptic periventricular nucleus of the hypothalamus and implicated in neuroendocrine modulation." [PMID:26132331, PMID:36209152] subset: human_subset subset: mouse_subset is_a: CL:0000700 ! dopaminergic neuron is_a: CL:0012001 ! neuron of the forebrain relationship: RO:0002100 UBERON:0002622 ! has soma location preoptic periventricular nucleus property_value: terms:date "2025-05-06T13:00:54Z" xsd:dateTime [Term] id: CL:4072013 name: A16 dopaminergic neuron def: "A type of dopaminergic interneuron located in the glomerular layer of the main olfactory bulb, characterized by the co-release of dopamine and GABA, and involved in modulating sensory input within olfactory circuits." [doi:/10.1101/2023.08.29.554772, PMID:28261065] subset: human_subset subset: mouse_subset is_a: CL:0000700 ! dopaminergic neuron is_a: CL:0011005 ! GABAergic interneuron is_a: CL:1001434 ! olfactory bulb interneuron relationship: RO:0002100 UBERON:0005377 ! has soma location olfactory bulb glomerular layer property_value: terms:date "2025-05-06T13:12:14Z" xsd:dateTime [Term] id: CL:4072014 name: tanycyte of vascular organ of lamina terminalis def: "A specialized, non-ciliated ependymal glial cell located in the ventricular wall of the organum vasculosum of the lamina terminalis (OVLT) and characterized by elongated basal processes extending into the parenchyma to contact fenestrated capillaries. In mice, it is characterised by the expression of tight junction proteins (claudin 1, occludin, ZO-1) forming a continuous honeycomb junctional pattern. This cell contributes to a functional blood–cerebrospinal fluid (CSF) barrier at the ventricular interface of the OVLT." [PMID:23649873, PMID:26017494] subset: human_subset subset: mouse_subset synonym: "tanycyte-like cell of OVLT" EXACT [PMID:32071335] synonym: "Tanycyte-like cells in CVOs" BROAD [PMID:23649873] synonym: "tanycyte-like ependymal cell of OVLT" EXACT [PMID:32071335] is_a: CL:0002085 ! tanycyte is_a: CL:2000030 ! hypothalamus cell relationship: BFO:0000050 UBERON:0002689 ! part of supraoptic crest property_value: terms:date "2025-06-04T10:27:59Z" xsd:dateTime [Term] id: CL:4072015 name: monocyte-derived Kupffer cell def: "A Kupffer cell located within the hepatic sinusoids, derived from circulating bone marrow monocytes that acquire the phenotypic markers and functional properties of resident Kupffer cells through niche-dependent imprinting, typically following depletion of the embryonically derived Kupffer cell population. During liver injury, MoKCs become the dominant Kupffer cell subset, exhibiting enhanced proliferation, resistance to apoptosis, and key roles in tissue repair and fibrosis attenuation." [PMID:26813785, PMID:31561945, PMID:37740916] subset: human_subset subset: mouse_subset synonym: "MoKC" RELATED OMO:0003000 [PMID:37740916] is_a: CL:0000091 ! Kupffer cell relationship: RO:0002202 CL:0000860 ! develops from classical monocyte property_value: terms:date "2025-07-11T00:00:00Z" xsd:dateTime [Term] id: CL:4072016 name: NPY interneuron def: "An interneuron that expresses neuropeptide Y (NPY) and is mainly located in cortical layers II–III and VI, as well as in various brain regions such as the medial geniculate and inferior colliculus. The NPY cell population is physiologically diverse, displaying a range of firing behaviors, including adapting, fast-spiking, and accelerating patterns." [PMID:19295167, PMID:32376782] subset: human_subset subset: mouse_subset synonym: "NPY-expressing neocortical interneuron" RELATED [PMID:19295167] synonym: "NPY-expressing neuron" EXACT [PMID:32376782] is_a: BFO:0000002 is_a: CL:0011005 ! GABAergic interneuron relationship: RO:0002292 PR:000011387 ! expresses neuropeptide Y property_value: terms:date "2025-07-07T09:04:45Z" xsd:dateTime [Term] id: CL:4072017 name: agouti-related protein expressing neuron def: "A GABAergic neuron located in the arcuate nucleus of the hypothalamus that expresses agouti-related protein (AgRP). This neuron can coexpress AgRP, GABA, and neuropeptide Y (NPY) in mice, and plays a key role in integrating metabolic signals. It is activated by hunger-related hormones such as ghrelin and inhibited by satiety signals like leptin." [PMID:34469623, PMID:37957320, PMID:39719709] subset: human_subset subset: mouse_subset synonym: "AgRP neuron" RELATED OMO:0003000 [PMID:39719709] is_a: BFO:0000002 is_a: CL:0000617 ! GABAergic neuron is_a: CL:0012001 ! neuron of the forebrain relationship: RO:0002100 UBERON:0001932 ! has soma location arcuate nucleus of hypothalamus relationship: RO:0002292 PR:000003846 ! expresses agouti-related protein relationship: RO:0002292 PR:000011387 ! expresses neuropeptide Y property_value: terms:date "2025-07-07T09:55:43Z" xsd:dateTime [Term] id: CL:4072018 name: pacemaker neuron def: "A neuron that generates rhythmic bursts of action potentials independently of synaptic input. This intrinsic property enables it to maintain oscillatory activity even when isolated from other neurons. It populates the brainstem, hypothalamus, basal ganglia, spinal cord, and cerebellum. It plays a crucial role in regulating circadian rhythms in the suprachiasmatic nucleus, generating respiratory rhythms in the preBötzinger complex, and synchronizing neural networks." [PMID:31982322, PMID:39303139] subset: human_subset subset: mouse_subset is_a: CL:0000540 ! neuron property_value: terms:date "2025-07-07T12:37:16Z" xsd:dateTime [Term] id: CL:4072019 name: SCN pacemaker neuron def: "A type of neuron located in the suprachiasmatic nucleus (SCN) that possesses intrinsic circadian rhythmicity, characterized by strong and rhythmic expression of core clock genes and the ability to independently generate and sustain circadian oscillations. In mice, the specific subtypes Avp+/Nms+, Vip+/Nms+, and Cck+/C1ql3+ neurons have the most robust circadian gene expression and contribute to synchronizing and maintaining rhythmicity within the SCN network (Wen et al., 2020)." [PMID:20148688, PMID:32066983] subset: human_subset subset: mouse_subset synonym: "pacemaker neuron of the suprachiasmatic nucleus" EXACT [PMID:20148688] is_a: CL:0012001 ! neuron of the forebrain relationship: RO:0002100 UBERON:0002034 ! has soma location suprachiasmatic nucleus property_value: terms:date "2025-07-14T10:10:28Z" xsd:dateTime [Term] id: CL:4072021 name: corticotropin-releasing neuron def: "A specialised type of interneuron defined by the secretion of corticotropin-releasing hormone (CRH), a key peptide in activating the hypothalamic–pituitary–adrenal (HPA) axis during stress. It is primarily located in the paraventricular nucleus (PVN) of the hypothalamus, with additional presence in the hippocampus, piriform area, central amygdalar nucleus, Barrington’s nucleus, and inferior olivary complex (Peng et al., 2017)." [PMID:21871477, PMID:2785663, PMID:28790896, PMID:33158870, PMID:9662138] subset: human_subset subset: mouse_subset synonym: "CRF neuron" RELATED OMO:0003000 [PMID:33158870] synonym: "CRH neuron" RELATED OMO:0003000 [PMID:21871477] is_a: CL:0000099 ! interneuron is_a: CL:0000165 ! neuroendocrine cell is_a: CL:0000467 ! adrenocorticotropic hormone secreting cell property_value: terms:date "2025-07-14T12:17:35Z" xsd:dateTime [Term] id: CL:4072022 name: Lamp5 Lhx6 GABAergic interneuron (Homo sapiens) def: "A Lamp5 Lhx6 GABAergic interneuron of Homo sapiens. The standard transcriptomic reference data for this cell type can be found on the CellxGene census under the collection: 'Transcriptomic cytoarchitecture reveals principles of human neocortex organization', dataset: 'Supercluster: CGE-derived interneurons', Author Categories: 'CrossArea_subclass', Lamp5 Lhx6" [PMID:30382198, PMID:36007006, PMID:37824655, PMID:37824669, PMID:38712198] comment: Despite being clustered as CGE in this dataset, other studies suggest that the cell is of MGE origin because it expresses transcription factors such as LHX6 and NKX2-1, which are hallmark indicators of MGE-derived interneurons. Fate mapping experiments in mice have demonstrated that Lamp5+/Lhx6+ interneurons in both the hippocampus and neocortex arise from the MGE, and single-cell transcriptomic comparisons further show that primate neocortical Lamp5+/Lhx6+ cells closely resemble mouse hippocampal MGE-derived interneurons rather than classic CGE-derived types. The marker set CHST9, LAMP5 can identify the Human cell type Lamp5 Lhx6 neuron in the neocortex with a confidence of 0.821678322 (NS-Forest FBeta value). {xref="https://zenodo.org/records/11165918", xref="PMID:32999462"} subset: human_subset xref: https://cellxgene.cziscience.com/e/e4ddac12-f48f-4455-8e8d-c2a48a683437.cxg/ is_a: CL:4042013 ! Lamp5 Lhx6 neuron relationship: RO:0002162 NCBITaxon:9606 ! in taxon Homo sapiens property_value: RO:0002175 NCBITaxon:9606 property_value: terms:date "2025-07-31T14:01:52Z" xsd:dateTime [Term] id: CL:4072027 name: sst GABAergic interneuron (Homo sapiens) def: "A transcriptomically distinct GABAergic neuron located in the cerebral cortex that expresses somatostatin (sst). The standard transcriptomic reference data for this cell type can be found on the CellxGene census under the collection: 'Transcriptomic cytoarchitecture reveals principles of human neocortex organization', dataset: 'Supercluster: MGE-derived interneurons', Author Categories: 'CrossArea_subclass', cluster Sst." [https://cellxgene.cziscience.com/e/9c63201d-bfd9-41a8-bbbc-18d947556f3d.cxg/, PMID:27477017, PMID:33742131, PMID:37824655] subset: BDS_subset subset: cellxgene_subset subset: human_subset synonym: "SOM+ inhibitory interneuron (Homo sapiens)" RELATED [PMID:30001424] synonym: "somatostatin-expressing inhibitory interneuron (Homo sapiens)" RELATED [PMID:30001424] synonym: "SST+ IN (Homo sapiens)" RELATED [PMID:33742131] xref: ILX:0770152 is_a: CL:4023017 ! sst GABAergic interneuron relationship: RO:0002162 NCBITaxon:9606 ! in taxon Homo sapiens property_value: IAO:0000028 "sst interneuron (Homo sapiens)" xsd:string property_value: RO:0002175 NCBITaxon:9606 property_value: terms:contributor "https://orcid.org/0000-0002-5507-2103" xsd:string property_value: terms:date "2025-08-12T10:45:41Z" xsd:dateTime [Term] id: CL:4072029 name: pvalb GABAergic interneuron (Homo sapiens) def: "A transcriptomically distinct GABAergic interneuron with a soma located in a cerebral cortex and it expresses Parvalbumin. The standard transcriptomic reference data for this cell type can be found on the CellxGene census under the collection: 'Transcriptomic cytoarchitecture reveals principles of human neocortex organization', dataset: 'Supercluster: MGE-derived interneurons', Author Categories: 'CrossArea_subclass', cluster Pvalb." [https://cellxgene.cziscience.com/e/9c63201d-bfd9-41a8-bbbc-18d947556f3d.cxg/, PMID:27477017, PMID:37824655] subset: BDS_subset subset: cellxgene_subset subset: human_subset is_a: CL:4023018 ! pvalb GABAergic interneuron intersection_of: CL:4023018 ! pvalb GABAergic interneuron intersection_of: RO:0002162 NCBITaxon:9606 ! in taxon Homo sapiens relationship: RO:0002162 NCBITaxon:9606 ! in taxon Homo sapiens property_value: IAO:0000028 "pvalb interneuron (Homo sapiens)" xsd:string property_value: RO:0002175 NCBITaxon:9606 property_value: terms:contributor "https://orcid.org/0000-0002-5507-2103" xsd:string property_value: terms:date "2025-08-12T14:31:10Z" xsd:dateTime [Term] id: CL:4072031 name: sst chodl GABAergic interneuron (Homo sapiens) def: "A transcriptomically distinct sst GABAergic interneuron that also expresses Chodl. These neurons are rare and correspond to the only known interneurons with long-range projection. The standard transcriptomic reference data for this cell type can be found on the CellxGene census under the collection: 'Transcriptomic cytoarchitecture reveals principles of human neocortex organization', dataset: 'Supercluster: MGE-derived interneurons', Author Categories: 'CrossArea_subclass', clusters Sst Chodl." [https://cellxgene.cziscience.com/e/9c63201d-bfd9-41a8-bbbc-18d947556f3d.cxg/, PMID:15845086, PMID:31209381, PMID:33372656, PMID:37824655] comment: The marker set NPY can identify the Human cell type sst chodl GABAergic interneuron in the neocortex with a confidence of 0.894026187 (NS-Forest FBeta value). {xref="https://doi.org/10.5281/zenodo.11165918"} subset: cellxgene_subset subset: human_subset synonym: "long-range GABAergic interneuron (Homo sapiens)" BROAD [PMID:33372656] is_a: CL:4023121 ! sst chodl GABAergic interneuron relationship: RO:0002162 NCBITaxon:9606 ! in taxon Homo sapiens property_value: IAO:0000028 "sst chodl interneuron (Homo sapiens)" xsd:string property_value: RO:0002175 NCBITaxon:9606 property_value: terms:contributor "https://orcid.org/0000-0002-5507-2103" xsd:string property_value: terms:date "2025-09-04T10:20:07Z" xsd:dateTime [Term] id: CL:4072032 name: VIP GABAergic interneuron (Homo sapiens) def: "A transcriptomically distinct GABAergic neuron that expresses the vasoactive intestinal polypeptide and that has its soma located in the forebrain. The standard transcriptomic reference data for this cell type can be found on the CellxGene census under the collection: 'Transcriptomic cytoarchitecture reveals principles of human neocortex organization', dataset: 'Supercluster: CGE-derived interneurons', Author Categories: 'CrossArea_subclass', cluster Vip." [https://cellxgene.cziscience.com/e/e4ddac12-f48f-4455-8e8d-c2a48a683437.cxg/, PMID:33186530, PMID:37824655] comment: The marker set VIP can identify the Human cell type VIP GABAergic interneuron in the neocortex with a confidence of 0.855531344 (NS-Forest FBeta value). {xref="https://doi.org/10.5281/zenodo.11165918"} subset: BDS_subset subset: human_subset synonym: "Vip (Homo sapiens)" RELATED [ILX:0770151] synonym: "VIP neuron (Homo sapiens)" RELATED [PMID:36384143] synonym: "VIP type (Homo sapiens)" RELATED [PMID:37824655] synonym: "VIP-IN (Homo sapiens)" RELATED [PMID:33794534] xref: ILX:0770151 is_a: CL:4023016 ! VIP GABAergic interneuron relationship: RO:0002162 NCBITaxon:9606 ! in taxon Homo sapiens relationship: RO:0002292 PR:P01282 ! expresses VIP peptides (human) property_value: IAO:0000028 "VIP interneuron (Homo sapiens)" xsd:string property_value: RO:0002175 NCBITaxon:9606 property_value: terms:contributor "https://orcid.org/0000-0002-5507-2103" xsd:string property_value: terms:date "2025-09-04T10:52:00Z" xsd:dateTime property_value: terms:description "This neuronal type is distinguished by its heterogeneous morphology and electrophysiological characteristics (Pronneke et al., 2015,2020; Apicella and Marchionni, 2022). Variations in morphology and firing patterns are observed in human VIP interneurons. In a study by Lee et al., 2023, four distinct subtypes of VIP neurons were identified, each exhibiting unique morphologies, soma locations, and electrophysiological properties. These subtypes are defined according to their transcriptomic markers: LBH-VIP and CCD184-VIP, both of which display a bipolar morphology with axons and dendrites extending across cortical layers; and SY16-VIP and ADAMTSL1-VIP, characterized by a dendritic arbor that spreads horizontally within the same layer as the soma (Lee et al., 2023). Disruption or malfunction of VIP interneuron is implicated in neurodevelopmental disorders such as Rett Syndrome and Dravet Syndrome (Goff and Goldberg 2021)." xsd:string {xref="PMID:26420784", xref="PMID:31210267", xref="PMID:33794534", xref="PMID:35221922"} [Term] id: CL:4072034 name: lamp5 GABAergic interneuron (Homo sapiens) def: "A transcriptomically distinct GABAergic neuron located in the cerebral cortex that expresses Lamp5. The standard transcriptomic reference data for this cell type can be found on the CellxGene census under the collection: 'Transcriptomic cytoarchitecture reveals principles of human neocortex organization', dataset: 'Supercluster: CGE-derived interneurons', Author Categories: 'CrossArea_subclass', clusters Lamp5." [https://cellxgene.cziscience.com/e/e4ddac12-f48f-4455-8e8d-c2a48a683437.cxg/, PMID:30382198, PMID:37824655] comment: The marker set LINC00298, KIT can identify the Human cell type lamp5 GABAergic interneuron in the neocortex with a confidence of 0.814687838 (NS-Forest FBeta value). {xref="https://doi.org/10.5281/zenodo.11165918"} subset: BDS_subset subset: human_subset xref: ILX:0770149 is_a: CL:4023011 ! lamp5 GABAergic interneuron relationship: RO:0002162 NCBITaxon:9606 ! in taxon Homo sapiens property_value: IAO:0000028 "Lamp5 interneuron (Homo sapiens)" xsd:string property_value: RO:0002175 NCBITaxon:9606 property_value: terms:contributor "https://orcid.org/0000-0002-5507-2103" xsd:string property_value: terms:date "2025-09-04T14:48:07Z" xsd:dateTime [Term] id: CL:4072035 name: sncg GABAergic interneuron (Homo sapiens) def: "A transcriptomically distinct GABAergic neuron located in the cerebral cortex that expresses Gamma-synuclein. The standard transcriptomic reference data for this cell type can be found on the CellxGene census under the collection: 'Transcriptomic cytoarchitecture reveals principles of human neocortex organization', dataset: 'Supercluster: CGE-derived interneurons', Author Categories: 'CrossArea_subclass', clusters Sncg." [https://cellxgene.cziscience.com/e/e4ddac12-f48f-4455-8e8d-c2a48a683437.cxg/, PMID:33186530, PMID:37824655] comment: The marker set RXRG, THSD7B can identify the Human cell type sncg GABAergic interneuron in the neocortex with a confidence of 0.628943702 (NS-Forest FBeta value). {xref="https://doi.org/10.5281/zenodo.11165918"} subset: BDS_subset subset: cellxgene_subset subset: human_subset xref: ILX:0770150 is_a: CL:4023015 ! sncg GABAergic interneuron relationship: RO:0002162 NCBITaxon:9606 ! in taxon Homo sapiens relationship: RO:0002292 PR:O76070 ! expresses gamma-synuclein (human) property_value: IAO:0000028 "sncg interneuron (Homo sapiens)" xsd:string property_value: RO:0002175 NCBITaxon:9606 property_value: terms:contributor "https://orcid.org/0000-0002-5507-2103" xsd:string property_value: terms:date "2025-09-05T10:49:37Z" xsd:dateTime [Term] id: CL:4072036 name: PAX6 GABAergic interneuron (Homo sapiens) def: "A transcriptomically distinct GABAergic neuron located in the cerebral cortex that expresses the transcript PAX6. The standard transcriptomic reference data for this cell type can be found on the CellxGene census under the collection: 'Transcriptomic cytoarchitecture reveals principles of human neocortex organization', dataset: 'Supercluster: CGE-derived interneurons', Author Categories: 'CrossArea_subclass', clusters PAX" [https://cellxgene.cziscience.com/e/e4ddac12-f48f-4455-8e8d-c2a48a683437.cxg/, PMID:37824655] comment: The marker set RELN, HCRTR2 can identify the Human cell type PAX6 GABAergic interneuron in the neocortex with a confidence of 0.724125093 (NS-Forest FBeta value). {xref="https://doi.org/10.5281/zenodo.11165918"} subset: human_subset is_a: CL:4042032 ! PAX6 GABAergic interneuron relationship: RO:0002162 NCBITaxon:9606 ! in taxon Homo sapiens property_value: IAO:0000028 "Pax6 interneuron (Homo sapiens)" xsd:string property_value: RO:0002175 NCBITaxon:9606 property_value: terms:contributor "https://orcid.org/0000-0002-5507-2103" xsd:string property_value: terms:date "2025-09-10T08:47:34Z" xsd:dateTime [Term] id: CL:4072037 name: L2/3 intratelencephalic projecting glutamatergic neuron (Homo sapiens) def: "A transcriptomically distinct intratelencephalic-projecting glutamatergic neuron with a soma found between cortical layer 2-4. This intratelencephalic-projecting glutamatergic neuron has thin-tufted apical dendrites and extends its axonal projection into L5 in the neocortex. This neuronal type has a hyperpolarised resting membrane potential. The standard transcriptomic reference data for this cell type can be found on the CellxGene census under the collection: 'Transcriptomic cytoarchitecture reveals principles of human neocortex organization', dataset: 'Supercluster: IT-projecting excitatory neurons', Author Categories: 'CrossArea_subclass', clusters L2/3 IT." [https://cellxgene.cziscience.com/e/c3aa4f95-7a18-4a7d-8dd8-ca324d714363.cxg/, PMID:25622573, PMID:34004146, PMID:37292694, PMID:37824655] comment: The marker set ONECUT2, COL5A2 can identify the Human cell type L2/3 intratelencephalic projecting glutamatergic neuron in the neocortex with a confidence of 0.670149932 (NS-Forest FBeta value). {xref="https://doi.org/10.5281/zenodo.11165918"} subset: cellxgene_subset subset: human_subset synonym: "L2/3 IT (Homo sapiens)" RELATED OMO:0003000 [PMID:34004146] xref: ILX:0770156 is_a: BFO:0000002 is_a: CL:4030059 ! L2/3 intratelencephalic projecting glutamatergic neuron relationship: RO:0002162 NCBITaxon:9606 ! in taxon Homo sapiens property_value: IAO:0000028 "L2/3 IT (Homo sapiens)" xsd:string property_value: RO:0002175 NCBITaxon:9606 property_value: terms:contributor "https://orcid.org/0000-0002-5507-2103" xsd:string property_value: terms:date "2025-09-10T09:15:51Z" xsd:dateTime [Term] id: CL:4072038 name: L5 intratelencephalic projecting glutamatergic neuron (Homo sapiens) def: "An intratelencephalic-projecting glutamatergic neuron with a soma found in cortical layer 5. The standard transcriptomic reference data for this cell type can be found on the CellxGene census under the collection: 'Transcriptomic cytoarchitecture reveals principles of human neocortex organization', dataset: 'Supercluster: IT-projecting excitatory neurons', Author Categories: 'CrossArea_subclass', L5 IT." [https://cellxgene.cziscience.com/e/c3aa4f95-7a18-4a7d-8dd8-ca324d714363.cxg/, PMID:37292694, PMID:37609206, PMID:37824655] comment: The marker set ARSJ, RORB, KCNK2 can identify the Human cell type L5 intratelencephalic projecting glutamatergic neuron in the neocortex with a confidence of 0.764261336 (NS-Forest FBeta value). {xref="https://doi.org/10.5281/zenodo.11165918"} subset: cellxgene_subset subset: human_subset synonym: "L5 IT (Homo sapiens)" RELATED OMO:0003000 [PMID:37292694] xref: ILX:0770157 is_a: BFO:0000002 is_a: CL:4030064 ! L5 intratelencephalic projecting glutamatergic neuron relationship: RO:0002162 NCBITaxon:9606 ! in taxon Homo sapiens property_value: IAO:0000028 "L5 IT (Homo sapiens)" xsd:string property_value: RO:0002175 NCBITaxon:9606 property_value: terms:contributor "https://orcid.org/0000-0002-5507-2103" xsd:string property_value: terms:date "2025-09-10T09:47:23Z" xsd:dateTime [Term] id: CL:4072039 name: L4 intratelencephalic projecting glutamatergic neuron (Homo sapiens) def: "A transcriptomically distinct intratelencephalic-projecting glutamatergic neuron with a soma found in cortical layer 3-4. This neuron type can have a pyramidal, star-pyramidal or spiny stellate morphology and projects its output to L2/3 and L5A/B. The standard transcriptomic reference data for this cell type can be found on the CellxGene census under the collection: 'Transcriptomic cytoarchitecture reveals principles of human neocortex organization', dataset: 'Supercluster: IT-projecting excitatory neurons', Author Categories: 'CrossArea_subclass', L4 IT." [https://cellxgene.cziscience.com/e/c3aa4f95-7a18-4a7d-8dd8-ca324d714363.cxg/, PMID:37292694, PMID:37824655] comment: The marker set RORB, ST8SIA4 can identify the Human cell type L4 intratelencephalic projecting glutamatergic neuron in the neocortex with a confidence of 0.720108696 (NS-Forest FBeta value). {xref="https://doi.org/10.5281/zenodo.11165918"} subset: cellxgene_subset subset: human_subset synonym: "L4 IT (Homo sapiens)" RELATED OMO:0003000 [PMID:37292694] is_a: BFO:0000002 is_a: CL:4030063 ! L4 intratelencephalic projecting glutamatergic neuron relationship: RO:0002162 NCBITaxon:9606 ! in taxon Homo sapiens property_value: IAO:0000028 "L4 IT (Homo sapiens)" xsd:string property_value: RO:0002175 NCBITaxon:9606 property_value: terms:date "2025-09-10T10:05:26Z" xsd:dateTime [Term] id: CL:4072040 name: L6 intratelencephalic projecting Car3 glutamatergic neuron (Homo sapiens) def: "A transcriptomically distinct intratelencepalic-projecting glutamatergic neuron that expresses Car3 with a soma found in L6. The standard transcriptomic reference data for this cell type can be found on the CellxGene census under the collection: 'Transcriptomic cytoarchitecture reveals principles of human neocortex organization', dataset: 'Supercluster: IT-projecting excitatory neurons', Author Categories: 'CrossArea_cluster', L6 IT Car3." [doi:10.1007/s00424-024-02923-2, doi:10.1101/2022.11.30.518285, https://cellxgene.cziscience.com/e/c3aa4f95-7a18-4a7d-8dd8-ca324d714363.cxg/, PMID:34004146, PMID:37824655] comment: The marker set SMYD1, THEMIS can identify the Human cell type L6 intratelencephalic projecting Car3 glutamatergic neuron in the neocortex with a confidence of 0.877752028 (NS-Forest FBeta value). {xref="https://doi.org/10.5281/zenodo.11165918"} subset: human_subset synonym: "L6 IT Car3 (Homo sapiens)" RELATED OMO:0003000 [doi:10.1101/2022.11.06.515349] synonym: "L6 IT Car3 glutamatergic neuron (Homo sapiens)" EXACT OMO:0003000 [doi:10.1101/2022.11.06.515349] synonym: "L6 IT Car3 neuron (Homo sapiens)" RELATED OMO:0003000 [PMID:37824655] synonym: "L6-IT-Car3 (Homo sapiens)" RELATED OMO:0003000 [doi:10.1101/2022.11.30.518285] synonym: "L6-IT-Car3 cell (Homo sapiens)" RELATED OMO:0003000 [PMID:37824655] is_a: CL:4030068 ! L6 intratelencephalic projecting Car3 glutamatergic neuron relationship: RO:0002162 NCBITaxon:9606 ! in taxon Homo sapiens property_value: IAO:0000028 "L6 IT Car3 (Homo sapiens)" xsd:string property_value: RO:0002175 NCBITaxon:9606 property_value: terms:contributor "https://orcid.org/0000-0002-5507-2103" xsd:string property_value: terms:date "2025-09-10T10:23:11Z" xsd:dateTime [Term] id: CL:4072041 name: L6 intratelencephalic projecting glutamatergic neuron (Homo sapiens) def: "A transcriptomically distinct intratelencephalic-projecting glutamatergic neuron with a soma found in L6 of the primary motor cortex. These cells are short untufted pyramidal cells, which could be stellate or inverted. The standard transcriptomic reference data for this cell type can be found on the CellxGene census under the collection: 'Transcriptomic cytoarchitecture reveals principles of human neocortex organization', dataset: 'Supercluster: IT-projecting excitatory neurons', Author Categories: 'CrossArea_subclass', L6 IT." [https://cellxgene.cziscience.com/e/c3aa4f95-7a18-4a7d-8dd8-ca324d714363.cxg/, PMID:37292694, PMID:37609206, PMID:37824655] comment: The marker set LINC00507, THEMIS can identify the Human cell type L6 intratelencephalic projecting glutamatergic neuron in the neocortex with a confidence of 0.641695703 (NS-Forest FBeta value). {xref="https://doi.org/10.5281/zenodo.11165918"} subset: cellxgene_subset subset: human_subset synonym: "L6 IT (Homo sapiens)" RELATED OMO:0003000 [PMID:37292694] xref: ILX:0770158 is_a: BFO:0000002 is_a: CL:4030065 ! L6 intratelencephalic projecting glutamatergic neuron relationship: RO:0002162 NCBITaxon:9606 ! in taxon Homo sapiens property_value: IAO:0000028 "L6 IT (Homo sapiens)" xsd:string property_value: RO:0002175 NCBITaxon:9606 property_value: terms:contributor "https://orcid.org/0000-0002-5507-2103" xsd:string property_value: terms:date "2025-09-11T14:38:02Z" xsd:dateTime [Term] id: CL:4072042 name: L5/6 near-projecting glutamatergic neuron (Homo sapiens) def: "A transcriptomically defined near-projecting glutamatergic neuron with a soma found in cortical layer 5/6 in humans." [https://cellxgene.cziscience.com/e/d01c9dff-abd1-4825-bf30-2eb2ba74597e.cxg/, PMID:34004146, PMID:37292694, PMID:37824655] comment: The marker set NPSR1-AS1, TLL1 can identify the Human cell type L5/6 near-projecting glutamatergic neuron in the neocortex with a confidence of 0.899288218 (NS-Forest FBeta value). {xref="https://doi.org/10.5281/zenodo.11165918"} subset: cellxgene_subset subset: human_subset synonym: "L5/6 NP (Homo sapiens)" RELATED OMO:0003000 [PMID:34004146] is_a: BFO:0000002 is_a: CL:4030067 ! L5/6 near-projecting glutamatergic neuron relationship: RO:0002162 NCBITaxon:9606 ! in taxon Homo sapiens property_value: IAO:0000028 "L5/6 NP (Homo sapiens)" xsd:string property_value: RO:0002175 NCBITaxon:9606 property_value: terms:contributor "https://orcid.org/0000-0002-5507-2103" xsd:string property_value: terms:date "2025-09-16T08:55:09Z" xsd:dateTime [Term] id: CL:4072043 name: L5 extratelencephalic projecting glutamatergic cortical neuron (Homo sapiens) def: "A transcriptomically distinct glutamatergic neuron, with a soma found in the deeper portion of L5, that has long-range axonal projections including deep subcortical targets outside of the telencephalon and, in some cases, the spinal cord. While the L5 ET neuron projections are not limited to ET targets, they are clearly differentiated from the neuron subclasses whose projections are constrained to intratelencephalic (IT) targets. L5 ET neurons are generally the largest excitatory cortical neurons, typically having a thick apical dendrite with a prominent dendritic tuft in layer 1 and displaying burst-firing physiological characteristics. The standard transcriptomic reference data for this cell type can be found on the CellxGene census under the collection: 'Transcriptomic cytoarchitecture reveals principles of human neocortex organization', dataset: 'Supercluster: Deep layer (non-IT) excitatory neurons ', Author Categories: 'CrossArea_subclass', clusters L5 ET." [https://cellxgene.cziscience.com/e/d01c9dff-abd1-4825-bf30-2eb2ba74597e.cxg/, PMID:34616075, PMID:37824655] comment: The marker set CHST8, POU3F1 can identify the Human cell type L5 extratelencephalic projecting glutamatergic cortical neuron in the neocortex with a confidence of 0.815891473 (NS-Forest FBeta value). {xref="https://doi.org/10.5281/zenodo.11165918"} subset: BDS_subset subset: cellxgene_subset subset: human_subset synonym: "burst-firing layer 5 neuron (Homo sapiens)" EXACT [DOI:10.3389/fncel.2011.00001] synonym: "L5b neuron (Homo sapiens)" RELATED OMO:0003000 [DOI:10.1016/j.neuron.2011.07.029] synonym: "pyramidal tract (PT) neuron (Homo sapiens)" NARROW [DOI:10.1038/nrn3469] synonym: "Pyramidal tract-like (PT-l) (Homo sapiens)" EXACT [PMID:31626774] {comment="pyramidal tract-like is used because, unlike pyramidal tract neurons in the motor cortex, neurons in the structures like the auditory cortex do not project to the spinal cord."} synonym: "subcerebral projection (SCPN) neuron (Homo sapiens)" BROAD [DOI:10.1016/j.neuron.2005.08.030] synonym: "thick-tufted layer 5 (TTL5) pyramidal neuron (Homo sapiens)" EXACT [DOI:10.3389/fncel.2015.00233] is_a: BFO:0000002 is_a: CL:4023041 ! L5 extratelencephalic projecting glutamatergic cortical neuron relationship: RO:0002162 NCBITaxon:9606 ! in taxon Homo sapiens property_value: IAO:0000028 "L5 ET glut (Homo sapiens)" xsd:string property_value: RO:0002175 NCBITaxon:9606 property_value: terms:contributor "https://orcid.org/0000-0002-5507-2103" xsd:string property_value: terms:date "2025-09-16T09:26:37Z" xsd:dateTime [Term] id: CL:4072044 name: L6 corticothalamic-projecting glutamatergic cortical neuron (Homo sapiens) def: "A transcriptomically distinct corticothalamic-projecting neuron with a soma found in cortical layer 6. The standard transcriptomic reference data for this cell type can be found on the CellxGene census under the collection: 'Transcriptomic cytoarchitecture reveals principles of human neocortex organization', dataset: 'Supercluster: Deep layer (non-IT) excitatory neurons', Author Categories: 'CrossArea_subclass', clusters L6 CT." [https://cellxgene.cziscience.com/e/d01c9dff-abd1-4825-bf30-2eb2ba74597e.cxg/, PMID:34616075, PMID:37824655] comment: The marker set SEMA5B, ADAMTSL1, SULF1 can identify the Human cell type L6 corticothalamic-projecting glutamatergic cortical neuron in the neocortex with a confidence of 0.631898455 (NS-Forest FBeta value). {xref="https://doi.org/10.5281/zenodo.11165918"} subset: BDS_subset subset: cellxgene_subset subset: human_subset synonym: "L6 CT (Homo sapiens)" EXACT [PMID:28625486, PMID:34616075] is_a: BFO:0000002 is_a: CL:4023042 ! L6 corticothalamic-projecting glutamatergic cortical neuron relationship: RO:0002162 NCBITaxon:9606 ! in taxon Homo sapiens property_value: IAO:0000028 "L6 CT glut (Homo sapiens)" xsd:string property_value: RO:0002175 NCBITaxon:9606 property_value: terms:contributor "https://orcid.org/0000-0002-5507-2103" xsd:string property_value: terms:date "2025-09-16T09:42:20Z" xsd:dateTime [Term] id: CL:4072045 name: L6b glutamatergic cortical neuron (Homo sapiens) def: "A glutamatergic neuron with a soma found in cortical layer 6b. They are transcriptomically related to corticothalamic-projecting neurons but have differential projections to the thalamus or anterior cingulate. The standard transcriptomic reference data for this cell type can be found on the CellxGene census under the collection: 'Transcriptomic cytoarchitecture reveals principles of human neocortex organization', dataset: 'Supercluster: Deep layer (non-IT) excitatory neuron', Author Categories: 'CrossArea_subclass', cluster L6b." [DOI:10.1101/2020.10.19.34312, https://cellxgene.cziscience.com/e/d01c9dff-abd1-4825-bf30-2eb2ba74597e.cxg/, PMID:30382198, PMID:37824655] subset: BDS_subset subset: cellxgene_subset subset: human_subset xref: ILX:0770163 is_a: BFO:0000002 is_a: CL:4023038 ! L6b glutamatergic cortical neuron relationship: RO:0002162 NCBITaxon:9606 ! in taxon Homo sapiens property_value: IAO:0000028 "L6b glut (Homo sapiens)" xsd:string property_value: RO:0002175 NCBITaxon:9606 property_value: terms:contributor "https://orcid.org/0000-0002-5507-2103" xsd:string property_value: terms:date "2025-09-16T10:30:38Z" xsd:dateTime [Term] id: CL:4072046 name: pvalb chandelier GABAergic interneuron (Homo sapiens) def: "A transcriptomically definined GABAergic interneuron of the human pallium. These cells correspond to the classically defined pvalb chandelier neuron type. The standard transcriptomic reference data for this cell type can be found on the CellxGene census under the collection: 'Transcriptomic cytoarchitecture reveals principles of human neocortex organization', dataset: 'Supercluster: CGE-derived interneurons', Author Categories: 'CrossArea_subclass', clusters Chandelier." [https://cellxgene.cziscience.com/e/9c63201d-bfd9-41a8-bbbc-18d947556f3d.cxg/, PMID:27477017, PMID:37824655] comment: The marker set GPR149, CA8 can identify the Human cell type chandelier pvalb GABAergic cortical interneuron in the neocortex with a confidence of 0.799748111 (NS-Forest FBeta value). {xref="https://doi.org/10.5281/zenodo.11165918"} subset: BDS_subset subset: cellxgene_subset subset: human_subset synonym: "Chandelier PV (Homo sapiens)" EXACT [] synonym: "chandelier pvalb GABAergic interneuron (Homo sapiens)" EXACT [] xref: ILX:0107356 is_a: CL:4023036 ! pvalb chandelier GABAergic interneuron relationship: RO:0002162 NCBITaxon:9606 ! in taxon Homo sapiens property_value: IAO:0000028 "chandelier PV interneuron (Homo sapiens)" xsd:string property_value: RO:0002175 NCBITaxon:9606 property_value: terms:contributor "https://orcid.org/0000-0002-5507-2103" xsd:string property_value: terms:date "2025-09-29T10:07:47Z" xsd:dateTime [Term] id: CL:4072102 name: Purkinje layer interneuron def: "A type of GABAergic interneuron residing in the Purkinje cell layer of the cerebellar cortex." [PMID:35803588] subset: human_subset subset: mouse_subset synonym: "PLI" RELATED OMO:0003000 [PMID:35803588] is_a: CL:4023057 ! cerebellar inhibitory GABAergic interneuron intersection_of: CL:0000099 ! interneuron intersection_of: RO:0002100 UBERON:0002979 ! has soma location Purkinje cell layer of cerebellar cortex relationship: RO:0002100 UBERON:0002979 ! has soma location Purkinje cell layer of cerebellar cortex property_value: terms:date "2025-04-29T13:06:36Z" xsd:dateTime [Term] id: CL:4072103 name: hair follicle dermal stem cell def: "A bipotent mesenchymal stem cell that resides in the dermal sheath, specifically within the dermal sheath cup at the base of the hair follicle, characterized by its capacity for self-renewal and differentiation into both dermal sheath and dermal papilla cells throughout hair cycling. In humans, this cell is marked by enriched expression of gremlin-2 (GREM2) and dipeptidase-1 (DPEP1), and acts as a progenitor reservoir sustaining and regenerating the follicle's mesenchymal compartments." [PMID:25465495, PMID:29691589, PMID:35036581, PMID:35069694] subset: human_subset subset: mouse_subset synonym: "dermal sheath cup cell" NARROW [PMID:38016881] synonym: "hfDSC" RELATED OMO:0003000 [PMID:25465495] is_a: CL:0000134 ! mesenchymal stem cell is_a: CL:0002559 ! hair follicle cell intersection_of: CL:0000134 ! mesenchymal stem cell intersection_of: BFO:0000050 UBERON:0002073 ! part of hair follicle relationship: RO:0002215 GO:0042634 ! capable of regulation of hair cycle property_value: terms:contributor https://orcid.org/0009-0000-8480-9277 creation_date: 2025-11-05T11:49:53Z [Term] id: CL:4072104 name: fibrochondrocyte def: "A chondrocyte with hybrid fibroblastic-chondrogenic characteristics found in fibrocartilage, particularly in the avascular inner zone and transitional middle zone of the meniscus. In humans, fibrochondrocytes are marked by predominant expression of type I collagen (COL1A1) and fibril-associated collagens (COL3A1, COL6A1), while retaining type II collagen (COL2A1) expression and exhibiting lower SOX9 than hyaline chondrocytes. This molecular profile underlies the synthesis of abundant type I collagen essential for fibrocartilage matrix and reflects an intermediate phenotype between fibroblast and chondrocyte." [PMID:28939894, PMID:31871141, PMID:34608249] subset: human_subset subset: mouse_subset synonym: "FC" RELATED OMO:0003000 [PMID:31871141] synonym: "fibrocartilage chondrocyte" EXACT [PMID:34608249] synonym: "meniscus fibrochondrocyte" NARROW [PMID:28939894] is_a: CL:0000138 ! chondrocyte intersection_of: CL:0000138 ! chondrocyte intersection_of: BFO:0000050 UBERON:0001995 ! part of fibrocartilage relationship: BFO:0000050 UBERON:0001995 ! part of fibrocartilage relationship: RO:0002202 CL:0020021 ! develops from fibrochondrocyte progenitor cell relationship: RO:0002292 PR:000003264 ! expresses collagen alpha-1(I) chain relationship: RO:0002292 PR:000003328 ! expresses collagen alpha-1(III) chain relationship: RO:0002292 PR:000003353 ! expresses collagen alpha-1(VI) chain property_value: terms:contributor https://orcid.org/0009-0000-8480-9277 [Term] id: CL:4300028 name: cerebellar GABAergic neuron (Mmus) def: "A cerebellar neuron of the Mus musculus brain. Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Class:28 CB GABA." [https://doi.org/10.1038/s41586-023-06812-z] comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions. subset: mouse_subset synonym: "28 CB GABA" EXACT [] is_a: CL:0000617 ! GABAergic neuron is_a: CL:1001611 ! cerebellar neuron relationship: RO:0002100 MBA:512 ! has soma location Cerebellum relationship: RO:0002162 NCBITaxon:10090 ! in taxon Mus musculus property_value: CLM:0010003 CLM:5007648 {STATO:0000663="0.62880975"} property_value: IAO:0000028 "CB GABA (Mmus)" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIBMjggQ0IgR0FCQQAAAVFZNVM4S01PNUhMSlVGMFAwMEsAAgAAATE1Qks0N0RDSU9GMVNMTFVXOVAAAgAAAUNCR0MwVTMwVlY5SlBSNjBUSlUAAgAABAEBAoGsxo6BlhUgA4RqTf2EWBhNAAUABgEBAkZTMDBEWFYwVDlSMVg5Rko0UUUAA34AAAAEAAAIRzRJNEdGSlhKQjlBVFozUFRYMQAJTFZEQkpBVzhCSTVZU1MxUVVCRwAKAAsBbm9uZQACbm9uZQADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAABSzlKTjIzUDI0S1FDR0s5VTc1QQACSFNZWlBaVzE2NjlVODIxQldZUAADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIBMjggQ0IgR0FCQQAAAVFZNVM4S01PNUhMSlVGMFAwMEsAAgAAATE1Qks0N0RDSU9GMVNMTFVXOVAAAgAAAUNCR0MwVTMwVlY5SlBSNjBUSlUAAgAABAEAAoRQvx%2BDggl%2FA4SgGoeExD3ZBDJOUVRJRTdUQU1QOFBRQUhPNFAABYGvpkqB6awOgaCBR4CS1egGAAcAAAUABgEBAkZTMDBEWFYwVDlSMVg5Rko0UUUAA34AAAAEAAAIVkZPRllQRlFHUktVRFFVWjNGRgAJTFZEQkpBVzhCSTVZU1MxUVVCRwAKAAsBVExPS1dDTDk1UlUwM0Q5UEVURwACNzNHVlREWERFR0UyN00yWEpNVAADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAACAwA%3D" xsd:string {name="Reference data on Allen Brain Cell Atlas"} property_value: seeAlso "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_28.h5ad" xsd:string {comment="Warning large data file!", name="h5ad data file for CS20230722_CLAS_28"} [Term] id: CL:4300029 name: cerebellar glutamatergic neuron (Mmus) def: "A cerebellum glutamatergic neuron of the Mus musculus brain. Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Class:29 CB Glut." [https://doi.org/10.1038/s41586-023-06812-z] comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions. subset: mouse_subset synonym: "29 CB Glut" EXACT [] is_a: CL:2000028 ! cerebellum glutamatergic neuron relationship: RO:0002100 MBA:512 ! has soma location Cerebellum relationship: RO:0002162 NCBITaxon:10090 ! in taxon Mus musculus property_value: CLM:0010003 CLM:5007649 {STATO:0000663="0.7043236"} property_value: IAO:0000028 "CB Glut (Mmus)" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#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%2BDggl%2FA4SgGoeExD3ZBDJOUVRJRTdUQU1QOFBRQUhPNFAABYGvpkqB6awOgaCBR4CS1egGAAcAAAUABgEBAkZTMDBEWFYwVDlSMVg5Rko0UUUAA34AAAAEAAAIVkZPRllQRlFHUktVRFFVWjNGRgAJTFZEQkpBVzhCSTVZU1MxUVVCRwAKAAsBVExPS1dDTDk1UlUwM0Q5UEVURwACNzNHVlREWERFR0UyN00yWEpNVAADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAACAwA%3D" xsd:string {name="Reference data on Allen Brain Cell Atlas"} property_value: seeAlso "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_29.h5ad" xsd:string {comment="Warning large data file!", name="h5ad data file for CS20230722_CLAS_29"} [Term] id: CL:4300031 name: OPC-Oligo cell (Mmus) def: "A cell of the Mus musculus brain. Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Class:31 OPC-Oligo." [https://doi.org/10.1038/s41586-023-06812-z] comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions. subset: mouse_subset synonym: "31 OPC-Oligo" EXACT [] is_a: CL:0000255 ! eukaryotic cell relationship: RO:0002162 NCBITaxon:10090 ! in taxon Mus musculus property_value: CLM:0010003 CLM:5007651 {STATO:0000663="0.8972486"} property_value: IAO:0000028 "OPC-Oligo (Mmus)" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIBMzEgT1BDLU9saWdvAAABUVk1UzhLTU81SExKVUYwUDAwSwACAAABMTVCSzQ3RENJT0YxU0xMVVc5UAACAAABQ0JHQzBVMzBWVjlKUFI2MFRKVQACAAAEAQECgazGjoGWFSADhGpN%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%2BAAAABAAACFZGT0ZZUEZRR1JLVURRVVozRkYACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAVRMT0tXQ0w5NVJVMDNEOVBFVEcAAjczR1ZURFhERUdFMjdNMlhKTVQAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAgMA" xsd:string {name="Reference data on Allen Brain Cell Atlas"} property_value: seeAlso "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_31.h5ad" xsd:string {comment="Warning large data file!", name="h5ad data file for CS20230722_CLAS_31"} [Term] id: CL:4300101 name: STR D1 Gaba direct pathway medium spiny neuron (Mmus) def: "A direct pathway medium spiny neuron of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Prkch (Mmus), Slc32a1 (Mmus), Drd1 (Mmus). Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Subclass:061 STR D1 Gaba." [https://doi.org/10.1038/s41586-023-06812-z] comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions. subset: human_subset subset: mouse_subset synonym: "061 STR D1 Gaba" EXACT [] is_a: CL:4023026 ! direct pathway medium spiny neuron property_value: CLM:0010003 CLM:5000101 {STATO:0000663="0.70412517"} property_value: CLM:0010003 CLM:5007721 {STATO:0000663="0.71593535"} property_value: IAO:0000028 "STR D1 Gaba (Mmus)" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIBMDYxIFNUUiBEMSBHYWJhAAABMTVCSzQ3RENJT0YxU0xMVVc5UAACAAABQ0JHQzBVMzBWVjlKUFI2MFRKVQACAAAEAQECgazGjoGWFSADhGpN%2FYRYGE0ABQAGAQECUVk1UzhLTU81SExKVUYwUDAwSwADfgAAAAQAAAhHNEk0R0ZKWEpCOUFUWjNQVFgxAAlMVkRCSkFXOEJJNVlTUzFRVUJHAAoACwFub25lAAJub25lAAMBBAEAAiMwMDAwMDAAA8gBAAUBAQIjMDAwMDAwAAPIAQAAAAFLOUpOMjNQMjRLUUNHSzlVNzVBAAJIU1laUFpXMTY2OVU4MjFCV1lQAAMEAUZTMDBEWFYwVDlSMVg5Rko0UUUAAgAAAVFZNVM4S01PNUhMSlVGMFAwMEsAAgEwNjEgU1RSIEQxIEdhYmEAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIAAAFDQkdDMFUzMFZWOUpQUjYwVEpVAAIAAAQBAAKEUL8fg4IJfwOEoBqHhMQ92QQyTlFUSUU3VEFNUDhQUUFITzRQAAWBr6ZKgemsDoGggUeAktXoBgAHAAAFAAYBAQJRWTVTOEtNTzVITEpVRjBQMDBLAAN%2BAAAABAAACFZGT0ZZUEZRR1JLVURRVVozRkYACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAVRMT0tXQ0w5NVJVMDNEOVBFVEcAAjczR1ZURFhERUdFMjdNMlhKTVQAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAgMA" xsd:string {name="Reference data on Allen Brain Cell Atlas"} property_value: seeAlso "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_09.h5ad" xsd:string {comment="Warning large data file!", name="h5ad data file for CS20230722_CLAS_09"} [Term] id: CL:4300102 name: STR D2 Gaba indirect pathway medium spiny neuron (Mmus) def: "A indirect pathway medium spiny neuron of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Adora2a (Mmus), Phactr1 (Mmus), Pcp4l1 (Mmus). Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Subclass:062 STR D2 Gaba." [https://doi.org/10.1038/s41586-023-06812-z] comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions. subset: human_subset subset: mouse_subset synonym: "062 STR D2 Gaba" EXACT [] is_a: CL:4023029 ! indirect pathway medium spiny neuron property_value: CLM:0010003 CLM:5000102 {STATO:0000663="0.6617923"} property_value: CLM:0010003 CLM:5007722 {STATO:0000663="0.8310593"} property_value: IAO:0000028 "STR D2 Gaba (Mmus)" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIBMDYyIFNUUiBEMiBHYWJhAAABMTVCSzQ3RENJT0YxU0xMVVc5UAACAAABQ0JHQzBVMzBWVjlKUFI2MFRKVQACAAAEAQECgazGjoGWFSADhGpN%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%2BAAAABAAACFZGT0ZZUEZRR1JLVURRVVozRkYACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAVRMT0tXQ0w5NVJVMDNEOVBFVEcAAjczR1ZURFhERUdFMjdNMlhKTVQAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAgMA" xsd:string {name="Reference data on Allen Brain Cell Atlas"} property_value: seeAlso "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_09.h5ad" xsd:string {comment="Warning large data file!", name="h5ad data file for CS20230722_CLAS_09"} [Term] id: CL:4300348 name: DCO Il22 Gly-Gaba cerebellar neuron (Mmus) def: "A cerebellar neuron of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Tmem204 (Mmus), Slc6a5 (Mmus). Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Subclass:308 DCO Il22 Gly-Gaba." [https://doi.org/10.1038/s41586-023-06812-z] comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions. subset: mouse_subset synonym: "308 DCO Il22 Gly-Gaba" EXACT [] is_a: CL:0008059 ! GABA-Gly neuron is_a: CL:4300028 ! cerebellar GABAergic neuron (Mmus) property_value: CLM:0010003 CLM:5000348 {STATO:0000663="0.49118388"} property_value: CLM:0010003 CLM:5007968 {STATO:0000663="0.5344828"} property_value: IAO:0000028 "DCO Il22 Gly-Gaba (Mmus)" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIBMzA4IERDTyBJbDIyIEdseS1HYWJhAAABMTVCSzQ3RENJT0YxU0xMVVc5UAACAAABQ0JHQzBVMzBWVjlKUFI2MFRKVQACAAAEAQECgazGjoGWFSADhGpN%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%2BAAAABAAACFZGT0ZZUEZRR1JLVURRVVozRkYACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAVRMT0tXQ0w5NVJVMDNEOVBFVEcAAjczR1ZURFhERUdFMjdNMlhKTVQAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAgMA" xsd:string {name="Reference data on Allen Brain Cell Atlas"} property_value: seeAlso "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_28.h5ad" xsd:string {comment="Warning large data file!", name="h5ad data file for CS20230722_CLAS_28"} [Term] id: CL:4300349 name: Purkinje layer interneuron (Mmus) def: "A Purkinje layer interneuron of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Rgs6 (Mmus), Slc6a5 (Mmus), Shisa9 (Mmus), Zic1 (Mmus), Bmp6 (Mmus). Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Subclass:309 CB PLI Gly-Gaba." [https://doi.org/10.1038/s41586-023-06812-z] comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions. subset: mouse_subset synonym: "309 CB PLI Gly-Gaba" EXACT [] is_a: CL:4072102 ! Purkinje layer interneuron is_a: CL:4300028 ! cerebellar GABAergic neuron (Mmus) property_value: CLM:0010003 CLM:5000349 {STATO:0000663="0.023094688"} property_value: CLM:0010003 CLM:5007969 {STATO:0000663="0.56375134"} property_value: IAO:0000028 "CB PLI Gly-Gaba (Mmus)" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#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%2BDggl%2FA4SgGoeExD3ZBDJOUVRJRTdUQU1QOFBRQUhPNFAABYGvpkqB6awOgaCBR4CS1egGAAcAAAUABgEBAlFZNVM4S01PNUhMSlVGMFAwMEsAA34AAAAEAAAIVkZPRllQRlFHUktVRFFVWjNGRgAJTFZEQkpBVzhCSTVZU1MxUVVCRwAKAAsBVExPS1dDTDk1UlUwM0Q5UEVURwACNzNHVlREWERFR0UyN00yWEpNVAADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAACAwA%3D" xsd:string {name="Reference data on Allen Brain Cell Atlas"} property_value: seeAlso "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_28.h5ad" xsd:string {comment="Warning large data file!", name="h5ad data file for CS20230722_CLAS_28"} [Term] id: CL:4300351 name: CBX MLI Megf11 Gaba molecular layer interneuron (Mmus) def: "A molecular layer interneuron of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Homer3 (Mmus), Tfap2b (Mmus), Sorcs3 (Mmus), Cacna1e (Mmus). Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Subclass:311 CBX MLI Megf11 Gaba." [https://doi.org/10.1038/s41586-023-06812-z] comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions. subset: mouse_subset synonym: "311 CBX MLI Megf11 Gaba" EXACT [] is_a: CL:4042035 ! molecular layer interneuron is_a: CL:4300028 ! cerebellar GABAergic neuron (Mmus) property_value: CLM:0010003 CLM:5000351 {STATO:0000663="0.24193548"} property_value: CLM:0010003 CLM:5007971 {STATO:0000663="0.6644144"} property_value: IAO:0000028 "CBX MLI Megf11 Gaba (Mmus)" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIBMzExIENCWCBNTEkgTWVnZjExIEdhYmEAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIAAAFDQkdDMFUzMFZWOUpQUjYwVEpVAAIAAAQBAQKBrMaOgZYVIAOEak39hFgYTQAFAAYBAQJRWTVTOEtNTzVITEpVRjBQMDBLAAN%2BAAAABAAACEc0STRHRkpYSkI5QVRaM1BUWDEACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAW5vbmUAAm5vbmUAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAUs5Sk4yM1AyNEtRQ0dLOVU3NUEAAkhTWVpQWlcxNjY5VTgyMUJXWVAAAwQBRlMwMERYVjBUOVIxWDlGSjRRRQACAAABUVk1UzhLTU81SExKVUYwUDAwSwACATMxMSBDQlggTUxJIE1lZ2YxMSBHYWJhAAABMTVCSzQ3RENJT0YxU0xMVVc5UAACAAABQ0JHQzBVMzBWVjlKUFI2MFRKVQACAAAEAQAChFC%2FH4OCCX8DhKAah4TEPdkEMk5RVElFN1RBTVA4UFFBSE80UAAFga%2BmSoHprA6BoIFHgJLV6AYABwAABQAGAQECUVk1UzhLTU81SExKVUYwUDAwSwADfgAAAAQAAAhWRk9GWVBGUUdSS1VEUVVaM0ZGAAlMVkRCSkFXOEJJNVlTUzFRVUJHAAoACwFUTE9LV0NMOTVSVTAzRDlQRVRHAAI3M0dWVERYREVHRTI3TTJYSk1UAAMBBAEAAiMwMDAwMDAAA8gBAAUBAQIjMDAwMDAwAAPIAQAAAAIDAA%3D%3D" xsd:string {name="Reference data on Allen Brain Cell Atlas"} property_value: seeAlso "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_28.h5ad" xsd:string {comment="Warning large data file!", name="h5ad data file for CS20230722_CLAS_28"} [Term] id: CL:4300353 name: Purkinje cell (Mmus) def: "A Purkinje cell of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Pcp2 (Mmus). Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Subclass:313 CBX Purkinje Gaba." [https://doi.org/10.1038/s41586-023-06812-z] comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions. subset: mouse_subset synonym: "313 CBX Purkinje Gaba" EXACT [] is_a: CL:0000121 ! Purkinje cell is_a: CL:4300028 ! cerebellar GABAergic neuron (Mmus) property_value: CLM:0010003 CLM:5000353 {STATO:0000663="0.9569378"} property_value: CLM:0010003 CLM:5007973 {STATO:0000663="0.99375"} property_value: IAO:0000028 "CBX Purkinje Gaba (Mmus)" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIBMzEzIENCWCBQdXJraW5qZSBHYWJhAAABMTVCSzQ3RENJT0YxU0xMVVc5UAACAAABQ0JHQzBVMzBWVjlKUFI2MFRKVQACAAAEAQECgazGjoGWFSADhGpN%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%2BAAAABAAACFZGT0ZZUEZRR1JLVURRVVozRkYACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAVRMT0tXQ0w5NVJVMDNEOVBFVEcAAjczR1ZURFhERUdFMjdNMlhKTVQAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAgMA" xsd:string {name="Reference data on Allen Brain Cell Atlas"} property_value: seeAlso "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_28.h5ad" xsd:string {comment="Warning large data file!", name="h5ad data file for CS20230722_CLAS_28"} [Term] id: CL:4300354 name: cerebellar granule cell (Mmus) def: "A cerebellar granule cell of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Gabra6 (Mmus), Ror1 (Mmus). Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Subclass:314 CB Granule Glut." [https://doi.org/10.1038/s41586-023-06812-z] comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions. subset: mouse_subset synonym: "314 CB Granule Glut" EXACT [] is_a: CL:0001031 ! cerebellar granule cell is_a: CL:4300029 ! cerebellar glutamatergic neuron (Mmus) property_value: CLM:0010003 CLM:5000354 {STATO:0000663="0.62749004"} property_value: CLM:0010003 CLM:5007974 {STATO:0000663="0.8494624"} property_value: IAO:0000028 "CB Granule Glut (Mmus)" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#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%2BDggl%2FA4SgGoeExD3ZBDJOUVRJRTdUQU1QOFBRQUhPNFAABYGvpkqB6awOgaCBR4CS1egGAAcAAAUABgEBAlFZNVM4S01PNUhMSlVGMFAwMEsAA34AAAAEAAAIVkZPRllQRlFHUktVRFFVWjNGRgAJTFZEQkpBVzhCSTVZU1MxUVVCRwAKAAsBVExPS1dDTDk1UlUwM0Q5UEVURwACNzNHVlREWERFR0UyN00yWEpNVAADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAACAwA%3D" xsd:string {name="Reference data on Allen Brain Cell Atlas"} property_value: seeAlso "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_29.h5ad" xsd:string {comment="Warning large data file!", name="h5ad data file for CS20230722_CLAS_29"} [Term] id: CL:4300358 name: subcortical astrocyte (Mmus) def: "A transcriptomically defined type of astrocyte located predominantly in the ventral and posterior subcortical areas. It is distinguished from other cells in the brain by selective expression of Aqp4 (Mmus), Cd38 (Mmus), Agt (Mmus), Itih3 (Mmus). Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Subclass:318 Astro-NT NN." [https://doi.org/10.1038/s41586-023-06812-z] comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions. subset: human_subset subset: mouse_subset synonym: "318 Astro-NT NN" EXACT [] synonym: "non-telencephalic astrocyte" EXACT [] is_a: CL:0000127 ! astrocyte property_value: CLM:0010003 CLM:5000358 {STATO:0000663="0.4052198"} property_value: CLM:0010003 CLM:5007978 {STATO:0000663="0.6994048"} property_value: IAO:0000028 "Astro-NT NN (Mmus)" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIBMzE4IEFzdHJvLU5UIE5OAAABMTVCSzQ3RENJT0YxU0xMVVc5UAACAAABQ0JHQzBVMzBWVjlKUFI2MFRKVQACAAAEAQECgazGjoGWFSADhGpN%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%2BAAAABAAACFZGT0ZZUEZRR1JLVURRVVozRkYACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAVRMT0tXQ0w5NVJVMDNEOVBFVEcAAjczR1ZURFhERUdFMjdNMlhKTVQAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAgMA" xsd:string {name="Reference data on Allen Brain Cell Atlas"} property_value: seeAlso "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_30.h5ad" xsd:string {comment="Warning large data file!", name="h5ad data file for CS20230722_CLAS_30"} [Term] id: CL:4300359 name: astrocyte of cerebrum (Mmus) def: "A transcritpomically defined type of astrocytes primarily restricted to the dorsal regions of the cerebrum. It is distinguished from other cells in the brain by selective expression of Gja1 (Mmus), Lhx2 (Mmus), Gpc5 (Mmus), Nr2f1 (Mmus). Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Subclass:319 Astro-TE NN." [https://doi.org/10.1038/s41586-023-06812-z] comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions. subset: human_subset subset: mouse_subset synonym: "319 Astro-TE NN" EXACT [] synonym: "telencephalic astrocyte" EXACT [] is_a: CL:0000127 ! astrocyte property_value: CLM:0010003 CLM:5000359 {STATO:0000663="0.03968254"} property_value: CLM:0010003 CLM:5007979 {STATO:0000663="0.58093345"} property_value: IAO:0000028 "Astro-TE NN (Mmus)" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIBMzE5IEFzdHJvLVRFIE5OAAABMTVCSzQ3RENJT0YxU0xMVVc5UAACAAABQ0JHQzBVMzBWVjlKUFI2MFRKVQACAAAEAQECgazGjoGWFSADhGpN%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%2BAAAABAAACFZGT0ZZUEZRR1JLVURRVVozRkYACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAVRMT0tXQ0w5NVJVMDNEOVBFVEcAAjczR1ZURFhERUdFMjdNMlhKTVQAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAgMA" xsd:string {name="Reference data on Allen Brain Cell Atlas"} property_value: seeAlso "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_30.h5ad" xsd:string {comment="Warning large data file!", name="h5ad data file for CS20230722_CLAS_30"} [Term] id: CL:4300360 name: olfactory areas astrocyte (Mmus) def: "A transcriptomically defined type of astrocyte located exclusively in the olfactory areas. It is distinguished from other cells in the brain by selective expression of Gja1 (Mmus), Hs3st3a1 (Mmus). Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Subclass:320 Astro-OLF NN." [https://doi.org/10.1038/s41586-023-06812-z] comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions. subset: human_subset subset: mouse_subset synonym: "320 Astro-OLF NN" EXACT [] is_a: CL:0000127 ! astrocyte property_value: CLM:0010003 CLM:5000360 {STATO:0000663="0.67099565"} property_value: CLM:0010003 CLM:5007980 {STATO:0000663="0.6818182"} property_value: IAO:0000028 "Astro-OLF NN (Mmus)" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#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%2BDggl%2FA4SgGoeExD3ZBDJOUVRJRTdUQU1QOFBRQUhPNFAABYGvpkqB6awOgaCBR4CS1egGAAcAAAUABgEBAlFZNVM4S01PNUhMSlVGMFAwMEsAA34AAAAEAAAIVkZPRllQRlFHUktVRFFVWjNGRgAJTFZEQkpBVzhCSTVZU1MxUVVCRwAKAAsBVExPS1dDTDk1UlUwM0Q5UEVURwACNzNHVlREWERFR0UyN00yWEpNVAADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAACAwA%3D" xsd:string {name="Reference data on Allen Brain Cell Atlas"} property_value: seeAlso "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_30.h5ad" xsd:string {comment="Warning large data file!", name="h5ad data file for CS20230722_CLAS_30"} [Term] id: CL:4300362 name: tanycyte (Mmus) def: "A tanycyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Gpr50 (Mmus), Apoe (Mmus). Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Subclass:322 Tanycyte NN." [https://doi.org/10.1038/s41586-023-06812-z] comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions. subset: human_subset subset: mouse_subset synonym: "322 Tanycyte NN" EXACT [] is_a: CL:0002085 ! tanycyte property_value: CLM:0010003 CLM:5000362 {STATO:0000663="0.74880874"} property_value: CLM:0010003 CLM:5007982 {STATO:0000663="0.77756834"} property_value: IAO:0000028 "Tanycyte NN (Mmus)" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIBMzIyIFRhbnljeXRlIE5OAAABMTVCSzQ3RENJT0YxU0xMVVc5UAACAAABQ0JHQzBVMzBWVjlKUFI2MFRKVQACAAAEAQECgazGjoGWFSADhGpN%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%2BAAAABAAACFZGT0ZZUEZRR1JLVURRVVozRkYACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAVRMT0tXQ0w5NVJVMDNEOVBFVEcAAjczR1ZURFhERUdFMjdNMlhKTVQAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAgMA" xsd:string {name="Reference data on Allen Brain Cell Atlas"} property_value: seeAlso "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_30.h5ad" xsd:string {comment="Warning large data file!", name="h5ad data file for CS20230722_CLAS_30"} [Term] id: CL:4300363 name: ependymal cell (Mmus) def: "A ependymal cell of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Tmem212 (Mmus), Rarres2 (Mmus). Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Subclass:323 Ependymal NN." [https://doi.org/10.1038/s41586-023-06812-z] comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions. subset: human_subset subset: mouse_subset synonym: "323 Ependymal NN" EXACT [] is_a: CL:0000065 ! ependymal cell property_value: CLM:0010003 CLM:5000363 {STATO:0000663="0.9508816"} property_value: CLM:0010003 CLM:5007983 {STATO:0000663="0.97694635"} property_value: IAO:0000028 "Ependymal NN (Mmus)" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#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%2BDggl%2FA4SgGoeExD3ZBDJOUVRJRTdUQU1QOFBRQUhPNFAABYGvpkqB6awOgaCBR4CS1egGAAcAAAUABgEBAlFZNVM4S01PNUhMSlVGMFAwMEsAA34AAAAEAAAIVkZPRllQRlFHUktVRFFVWjNGRgAJTFZEQkpBVzhCSTVZU1MxUVVCRwAKAAsBVExPS1dDTDk1UlUwM0Q5UEVURwACNzNHVlREWERFR0UyN00yWEpNVAADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAACAwA%3D" xsd:string {name="Reference data on Allen Brain Cell Atlas"} property_value: seeAlso "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_30.h5ad" xsd:string {comment="Warning large data file!", name="h5ad data file for CS20230722_CLAS_30"} [Term] id: CL:4300366 name: oligodendrocyte precursor cell (Mmus) def: "A oligodendrocyte precursor cell of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Pdgfra (Mmus). Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Subclass:326 OPC NN." [https://doi.org/10.1038/s41586-023-06812-z] comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions. subset: mouse_subset synonym: "326 OPC NN" EXACT [] is_a: CL:0002453 ! oligodendrocyte precursor cell is_a: CL:4300031 ! OPC-Oligo cell (Mmus) property_value: CLM:0010003 CLM:5000366 {STATO:0000663="0.7124217"} property_value: CLM:0010003 CLM:5007986 {STATO:0000663="0.9503155"} property_value: IAO:0000028 "OPC NN (Mmus)" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#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%2BDggl%2FA4SgGoeExD3ZBDJOUVRJRTdUQU1QOFBRQUhPNFAABYGvpkqB6awOgaCBR4CS1egGAAcAAAUABgEBAlFZNVM4S01PNUhMSlVGMFAwMEsAA34AAAAEAAAIVkZPRllQRlFHUktVRFFVWjNGRgAJTFZEQkpBVzhCSTVZU1MxUVVCRwAKAAsBVExPS1dDTDk1UlUwM0Q5UEVURwACNzNHVlREWERFR0UyN00yWEpNVAADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAACAwA%3D" xsd:string {name="Reference data on Allen Brain Cell Atlas"} property_value: seeAlso "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_31.h5ad" xsd:string {comment="Warning large data file!", name="h5ad data file for CS20230722_CLAS_31"} [Term] id: CL:4300367 name: oligodendrocyte (Mmus) def: "A oligodendrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Cldn11 (Mmus), Gjc3 (Mmus). Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Subclass:327 Oligo NN." [https://doi.org/10.1038/s41586-023-06812-z] comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions. subset: mouse_subset synonym: "327 Oligo NN" EXACT [] is_a: CL:0000128 ! oligodendrocyte is_a: CL:4300031 ! OPC-Oligo cell (Mmus) property_value: CLM:0010003 CLM:5000367 {STATO:0000663="0.9230531"} property_value: CLM:0010003 CLM:5007987 {STATO:0000663="0.9235276"} property_value: IAO:0000028 "Oligo NN (Mmus)" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIBMzI3IE9saWdvIE5OAAABMTVCSzQ3RENJT0YxU0xMVVc5UAACAAABQ0JHQzBVMzBWVjlKUFI2MFRKVQACAAAEAQECgazGjoGWFSADhGpN%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%2BAAAABAAACFZGT0ZZUEZRR1JLVURRVVozRkYACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAVRMT0tXQ0w5NVJVMDNEOVBFVEcAAjczR1ZURFhERUdFMjdNMlhKTVQAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAgMA" xsd:string {name="Reference data on Allen Brain Cell Atlas"} property_value: seeAlso "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_31.h5ad" xsd:string {comment="Warning large data file!", name="h5ad data file for CS20230722_CLAS_31"} [Term] id: CL:4300370 name: VLMC NN vascular leptomeningeal cell (Mmus) def: "A vascular leptomeningeal cell of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Apod (Mmus), Slc6a13 (Mmus). Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Subclass:330 VLMC NN." [https://doi.org/10.1038/s41586-023-06812-z] comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions. subset: mouse_subset synonym: "330 VLMC NN" EXACT [] is_a: CL:4023051 ! vascular leptomeningeal cell relationship: RO:0002162 NCBITaxon:10090 ! in taxon Mus musculus property_value: CLM:0010003 CLM:5000370 {STATO:0000663="0.8806818"} property_value: CLM:0010003 CLM:5007990 {STATO:0000663="0.8556548"} property_value: IAO:0000028 "VLMC NN (Mmus)" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIBMzMwIFZMTUMgTk4AAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIAAAFDQkdDMFUzMFZWOUpQUjYwVEpVAAIAAAQBAQKBrMaOgZYVIAOEak39hFgYTQAFAAYBAQJRWTVTOEtNTzVITEpVRjBQMDBLAAN%2BAAAABAAACEc0STRHRkpYSkI5QVRaM1BUWDEACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAW5vbmUAAm5vbmUAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAUs5Sk4yM1AyNEtRQ0dLOVU3NUEAAkhTWVpQWlcxNjY5VTgyMUJXWVAAAwQBRlMwMERYVjBUOVIxWDlGSjRRRQACAAABUVk1UzhLTU81SExKVUYwUDAwSwACATMzMCBWTE1DIE5OAAABMTVCSzQ3RENJT0YxU0xMVVc5UAACAAABQ0JHQzBVMzBWVjlKUFI2MFRKVQACAAAEAQAChFC%2FH4OCCX8DhKAah4TEPdkEMk5RVElFN1RBTVA4UFFBSE80UAAFga%2BmSoHprA6BoIFHgJLV6AYABwAABQAGAQECUVk1UzhLTU81SExKVUYwUDAwSwADfgAAAAQAAAhWRk9GWVBGUUdSS1VEUVVaM0ZGAAlMVkRCSkFXOEJJNVlTUzFRVUJHAAoACwFUTE9LV0NMOTVSVTAzRDlQRVRHAAI3M0dWVERYREVHRTI3TTJYSk1UAAMBBAEAAiMwMDAwMDAAA8gBAAUBAQIjMDAwMDAwAAPIAQAAAAIDAA%3D%3D" xsd:string {name="Reference data on Allen Brain Cell Atlas"} property_value: seeAlso "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_33.h5ad" xsd:string {comment="Warning large data file!", name="h5ad data file for CS20230722_CLAS_33"} [Term] id: CL:4301571 name: DCO Il22 Gly-Gaba_1 cerebellar neuron (Mmus) def: "A cerebellar neuron of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Il22 (Mmus), Rftn1 (Mmus). Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Supertype:1141 DCO Il22 Gly-Gaba_1." [https://doi.org/10.1038/s41586-023-06812-z] comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions. subset: mouse_subset synonym: "1141 DCO Il22 Gly-Gaba_1" EXACT [] is_a: CL:4300348 ! DCO Il22 Gly-Gaba cerebellar neuron (Mmus) property_value: CLM:0010003 CLM:5001561 {STATO:0000663="0.2741228"} property_value: CLM:0010003 CLM:5016781 property_value: IAO:0000028 "DCO Il22 Gly-Gaba_1 (Mmus)" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIBMTE0MSBEQ08gSWwyMiBHbHktR2FiYV8xAAABQ0JHQzBVMzBWVjlKUFI2MFRKVQACAAAEAQECgazGjoGWFSADhGpN%2FYRYGE0ABQAGAQECMTVCSzQ3RENJT0YxU0xMVVc5UAADfgAAAAQAAAhHNEk0R0ZKWEpCOUFUWjNQVFgxAAlMVkRCSkFXOEJJNVlTUzFRVUJHAAoACwFub25lAAJub25lAAMBBAEAAiMwMDAwMDAAA8gBAAUBAQIjMDAwMDAwAAPIAQAAAAFLOUpOMjNQMjRLUUNHSzlVNzVBAAJIU1laUFpXMTY2OVU4MjFCV1lQAAMEAUZTMDBEWFYwVDlSMVg5Rko0UUUAAgAAAVFZNVM4S01PNUhMSlVGMFAwMEsAAgAAATE1Qks0N0RDSU9GMVNMTFVXOVAAAgExMTQxIERDTyBJbDIyIEdseS1HYWJhXzEAAAFDQkdDMFUzMFZWOUpQUjYwVEpVAAIAAAQBAAKEUL8fg4IJfwOEoBqHhMQ92QQyTlFUSUU3VEFNUDhQUUFITzRQAAWBr6ZKgemsDoGggUeAktXoBgAHAAAFAAYBAQIxNUJLNDdEQ0lPRjFTTExVVzlQAAN%2BAAAABAAACFZGT0ZZUEZRR1JLVURRVVozRkYACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAVRMT0tXQ0w5NVJVMDNEOVBFVEcAAjczR1ZURFhERUdFMjdNMlhKTVQAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAgMA" xsd:string {name="Reference data on Allen Brain Cell Atlas"} property_value: seeAlso "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_28.h5ad" xsd:string {comment="Warning large data file!", name="h5ad data file for CS20230722_CLAS_28"} [Term] id: CL:4301573 name: DCO Il22 Gly-Gaba_3 cerebellar neuron (Mmus) def: "A cerebellar neuron of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Fat2 (Mmus), Slc6a5 (Mmus), Cgnl1 (Mmus). Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Supertype:1143 DCO Il22 Gly-Gaba_3." [https://doi.org/10.1038/s41586-023-06812-z] comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions. subset: mouse_subset synonym: "1143 DCO Il22 Gly-Gaba_3" EXACT [] is_a: CL:4300348 ! DCO Il22 Gly-Gaba cerebellar neuron (Mmus) property_value: CLM:0010003 CLM:5001563 {STATO:0000663="0.4560811"} property_value: CLM:0010003 CLM:5016783 property_value: IAO:0000028 "DCO Il22 Gly-Gaba_3 (Mmus)" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIBMTE0MyBEQ08gSWwyMiBHbHktR2FiYV8zAAABQ0JHQzBVMzBWVjlKUFI2MFRKVQACAAAEAQECgazGjoGWFSADhGpN%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%2BAAAABAAACFZGT0ZZUEZRR1JLVURRVVozRkYACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAVRMT0tXQ0w5NVJVMDNEOVBFVEcAAjczR1ZURFhERUdFMjdNMlhKTVQAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAgMA" xsd:string {name="Reference data on Allen Brain Cell Atlas"} property_value: seeAlso "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_28.h5ad" xsd:string {comment="Warning large data file!", name="h5ad data file for CS20230722_CLAS_28"} [Term] id: CL:4301574 name: CB PLI Gly-Gaba_1 Purkinje layer interneuron (Mmus) def: "A Purkinje layer interneuron of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Hmga2 (Mmus), Afap1l2 (Mmus). Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Supertype:1144 CB PLI Gly-Gaba_1." [https://doi.org/10.1038/s41586-023-06812-z] comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions. subset: mouse_subset synonym: "1144 CB PLI Gly-Gaba_1" EXACT [] is_a: CL:4300349 ! Purkinje layer interneuron (Mmus) property_value: CLM:0010003 CLM:5001564 {STATO:0000663="0.49407116"} property_value: CLM:0010003 CLM:5016784 property_value: IAO:0000028 "CB PLI Gly-Gaba_1 (Mmus)" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#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%2BDggl%2FA4SgGoeExD3ZBDJOUVRJRTdUQU1QOFBRQUhPNFAABYGvpkqB6awOgaCBR4CS1egGAAcAAAUABgEBAjE1Qks0N0RDSU9GMVNMTFVXOVAAA34AAAAEAAAIVkZPRllQRlFHUktVRFFVWjNGRgAJTFZEQkpBVzhCSTVZU1MxUVVCRwAKAAsBVExPS1dDTDk1UlUwM0Q5UEVURwACNzNHVlREWERFR0UyN00yWEpNVAADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAACAwA%3D" xsd:string {name="Reference data on Allen Brain Cell Atlas"} property_value: seeAlso "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_28.h5ad" xsd:string {comment="Warning large data file!", name="h5ad data file for CS20230722_CLAS_28"} [Term] id: CL:4301575 name: Lugaro cell (Mmus) def: "A Lugaro cell of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Pthlh (Mmus), Tfap2b (Mmus), Rspo2 (Mmus). Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Supertype:1145 CB PLI Gly-Gaba_2." [https://doi.org/10.1038/s41586-023-06812-z] comment: Rationale for assigning this type to reference data: Mapping of this cell type is supported by analysis: https://github.com/Cellular-Semantics/cellular_semantics_notebooks Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions. subset: mouse_subset synonym: "1145 CB PLI Gly-Gaba_2" EXACT [] is_a: CL:0011006 ! Lugaro cell is_a: CL:4300349 ! Purkinje layer interneuron (Mmus) property_value: CLM:0010003 CLM:5001565 {STATO:0000663="0.74850297"} property_value: CLM:0010003 CLM:5016785 property_value: IAO:0000028 "CB PLI Gly-Gaba_2 (Mmus)" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#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%2BDggl%2FA4SgGoeExD3ZBDJOUVRJRTdUQU1QOFBRQUhPNFAABYGvpkqB6awOgaCBR4CS1egGAAcAAAUABgEBAjE1Qks0N0RDSU9GMVNMTFVXOVAAA34AAAAEAAAIVkZPRllQRlFHUktVRFFVWjNGRgAJTFZEQkpBVzhCSTVZU1MxUVVCRwAKAAsBVExPS1dDTDk1UlUwM0Q5UEVURwACNzNHVlREWERFR0UyN00yWEpNVAADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAACAwA%3D" xsd:string {name="Reference data on Allen Brain Cell Atlas"} property_value: seeAlso "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_28.h5ad" xsd:string {comment="Warning large data file!", name="h5ad data file for CS20230722_CLAS_28"} [Term] id: CL:4301576 name: CB PLI Gly-Gaba_3 Purkinje layer interneuron (Mmus) def: "A Purkinje layer interneuron of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Pax2 (Mmus), C1ql3 (Mmus), Tfap2b (Mmus), Gabrb1 (Mmus). Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Supertype:1146 CB PLI Gly-Gaba_3." [https://doi.org/10.1038/s41586-023-06812-z] comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions. subset: mouse_subset synonym: "1146 CB PLI Gly-Gaba_3" EXACT [] is_a: CL:4300349 ! Purkinje layer interneuron (Mmus) property_value: CLM:0010003 CLM:5001566 {STATO:0000663="0.30487806"} property_value: CLM:0010003 CLM:5016786 property_value: IAO:0000028 "CB PLI Gly-Gaba_3 (Mmus)" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#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%2BDggl%2FA4SgGoeExD3ZBDJOUVRJRTdUQU1QOFBRQUhPNFAABYGvpkqB6awOgaCBR4CS1egGAAcAAAUABgEBAjE1Qks0N0RDSU9GMVNMTFVXOVAAA34AAAAEAAAIVkZPRllQRlFHUktVRFFVWjNGRgAJTFZEQkpBVzhCSTVZU1MxUVVCRwAKAAsBVExPS1dDTDk1UlUwM0Q5UEVURwACNzNHVlREWERFR0UyN00yWEpNVAADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAACAwA%3D" xsd:string {name="Reference data on Allen Brain Cell Atlas"} property_value: seeAlso "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_28.h5ad" xsd:string {comment="Warning large data file!", name="h5ad data file for CS20230722_CLAS_28"} [Term] id: CL:4301578 name: cerebellar Golgi cell (Mmus) def: "A cerebellar Golgi cell of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Zfp385c (Mmus), Tfap2b (Mmus). Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Supertype:1148 CBX Golgi Gly-Gaba_1." [https://doi.org/10.1038/s41586-023-06812-z] comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions. subset: mouse_subset synonym: "1148 CBX Golgi Gly-Gaba_1" EXACT [] synonym: "310 CBX Golgi Gly-Gaba" EXACT [] is_a: CL:0000119 ! cerebellar Golgi cell is_a: CL:4300028 ! cerebellar GABAergic neuron (Mmus) property_value: CLM:0010003 CLM:5001568 {STATO:0000663="0.610687"} property_value: CLM:0010003 CLM:5007970 {STATO:0000663="0.87349397"} property_value: CLM:0010003 CLM:5016788 property_value: IAO:0000028 "CBX Golgi Gly-Gaba (Mmus)" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#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%2BDggl%2FA4SgGoeExD3ZBDJOUVRJRTdUQU1QOFBRQUhPNFAABYGvpkqB6awOgaCBR4CS1egGAAcAAAUABgEBAlFZNVM4S01PNUhMSlVGMFAwMEsAA34AAAAEAAAIVkZPRllQRlFHUktVRFFVWjNGRgAJTFZEQkpBVzhCSTVZU1MxUVVCRwAKAAsBVExPS1dDTDk1UlUwM0Q5UEVURwACNzNHVlREWERFR0UyN00yWEpNVAADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAACAwA%3D" xsd:string {name="Reference data on Allen Brain Cell Atlas"} property_value: seeAlso "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_28.h5ad" xsd:string {comment="Warning large data file!", name="h5ad data file for CS20230722_CLAS_28"} [Term] id: CL:4301579 name: CBX MLI Megf11 Gaba_1 molecular layer interneuron (Mmus) def: "A molecular layer interneuron of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Dnah11 (Mmus), Sla (Mmus), Gldc (Mmus), Sdk2 (Mmus). Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Supertype:1149 CBX MLI Megf11 Gaba_1." [https://doi.org/10.1038/s41586-023-06812-z] comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions. subset: mouse_subset synonym: "1149 CBX MLI Megf11 Gaba_1" EXACT [] is_a: CL:4300351 ! CBX MLI Megf11 Gaba molecular layer interneuron (Mmus) property_value: CLM:0010003 CLM:5001569 {STATO:0000663="0.3030303"} property_value: CLM:0010003 CLM:5016789 property_value: IAO:0000028 "CBX MLI Megf11 Gaba_1 (Mmus)" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIBMTE0OSBDQlggTUxJIE1lZ2YxMSBHYWJhXzEAAAFDQkdDMFUzMFZWOUpQUjYwVEpVAAIAAAQBAQKBrMaOgZYVIAOEak39hFgYTQAFAAYBAQIxNUJLNDdEQ0lPRjFTTExVVzlQAAN%2BAAAABAAACEc0STRHRkpYSkI5QVRaM1BUWDEACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAW5vbmUAAm5vbmUAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAUs5Sk4yM1AyNEtRQ0dLOVU3NUEAAkhTWVpQWlcxNjY5VTgyMUJXWVAAAwQBRlMwMERYVjBUOVIxWDlGSjRRRQACAAABUVk1UzhLTU81SExKVUYwUDAwSwACAAABMTVCSzQ3RENJT0YxU0xMVVc5UAACATExNDkgQ0JYIE1MSSBNZWdmMTEgR2FiYV8xAAABQ0JHQzBVMzBWVjlKUFI2MFRKVQACAAAEAQAChFC%2FH4OCCX8DhKAah4TEPdkEMk5RVElFN1RBTVA4UFFBSE80UAAFga%2BmSoHprA6BoIFHgJLV6AYABwAABQAGAQECMTVCSzQ3RENJT0YxU0xMVVc5UAADfgAAAAQAAAhWRk9GWVBGUUdSS1VEUVVaM0ZGAAlMVkRCSkFXOEJJNVlTUzFRVUJHAAoACwFUTE9LV0NMOTVSVTAzRDlQRVRHAAI3M0dWVERYREVHRTI3TTJYSk1UAAMBBAEAAiMwMDAwMDAAA8gBAAUBAQIjMDAwMDAwAAPIAQAAAAIDAA%3D%3D" xsd:string {name="Reference data on Allen Brain Cell Atlas"} property_value: seeAlso "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_28.h5ad" xsd:string {comment="Warning large data file!", name="h5ad data file for CS20230722_CLAS_28"} [Term] id: CL:4301580 name: CBX MLI Megf11 Gaba_2 molecular layer interneuron (Mmus) def: "A molecular layer interneuron of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Gabra6 (Mmus), Pvalb (Mmus). Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Supertype:1150 CBX MLI Megf11 Gaba_2." [https://doi.org/10.1038/s41586-023-06812-z] comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions. subset: mouse_subset synonym: "1150 CBX MLI Megf11 Gaba_2" EXACT [] is_a: CL:4300351 ! CBX MLI Megf11 Gaba molecular layer interneuron (Mmus) property_value: CLM:0010003 CLM:5001570 {STATO:0000663="0.7986111"} property_value: CLM:0010003 CLM:5016790 property_value: IAO:0000028 "CBX MLI Megf11 Gaba_2 (Mmus)" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIBMTE1MCBDQlggTUxJIE1lZ2YxMSBHYWJhXzIAAAFDQkdDMFUzMFZWOUpQUjYwVEpVAAIAAAQBAQKBrMaOgZYVIAOEak39hFgYTQAFAAYBAQIxNUJLNDdEQ0lPRjFTTExVVzlQAAN%2BAAAABAAACEc0STRHRkpYSkI5QVRaM1BUWDEACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAW5vbmUAAm5vbmUAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAUs5Sk4yM1AyNEtRQ0dLOVU3NUEAAkhTWVpQWlcxNjY5VTgyMUJXWVAAAwQBRlMwMERYVjBUOVIxWDlGSjRRRQACAAABUVk1UzhLTU81SExKVUYwUDAwSwACAAABMTVCSzQ3RENJT0YxU0xMVVc5UAACATExNTAgQ0JYIE1MSSBNZWdmMTEgR2FiYV8yAAABQ0JHQzBVMzBWVjlKUFI2MFRKVQACAAAEAQAChFC%2FH4OCCX8DhKAah4TEPdkEMk5RVElFN1RBTVA4UFFBSE80UAAFga%2BmSoHprA6BoIFHgJLV6AYABwAABQAGAQECMTVCSzQ3RENJT0YxU0xMVVc5UAADfgAAAAQAAAhWRk9GWVBGUUdSS1VEUVVaM0ZGAAlMVkRCSkFXOEJJNVlTUzFRVUJHAAoACwFUTE9LV0NMOTVSVTAzRDlQRVRHAAI3M0dWVERYREVHRTI3TTJYSk1UAAMBBAEAAiMwMDAwMDAAA8gBAAUBAQIjMDAwMDAwAAPIAQAAAAIDAA%3D%3D" xsd:string {name="Reference data on Allen Brain Cell Atlas"} property_value: seeAlso "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_28.h5ad" xsd:string {comment="Warning large data file!", name="h5ad data file for CS20230722_CLAS_28"} [Term] id: CL:4301582 name: CBX Purkinje Gaba_1 Purkinje cell (Mmus) def: "A Purkinje cell of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Pcp2 (Mmus), Stk17b (Mmus). Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Supertype:1152 CBX Purkinje Gaba_1." [https://doi.org/10.1038/s41586-023-06812-z] comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions. subset: mouse_subset synonym: "1152 CBX Purkinje Gaba_1" EXACT [] is_a: CL:4300353 ! Purkinje cell (Mmus) property_value: CLM:0010003 CLM:5001572 {STATO:0000663="0.608828"} property_value: CLM:0010003 CLM:5016792 property_value: IAO:0000028 "CBX Purkinje Gaba_1 (Mmus)" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIBMTE1MiBDQlggUHVya2luamUgR2FiYV8xAAABQ0JHQzBVMzBWVjlKUFI2MFRKVQACAAAEAQECgazGjoGWFSADhGpN%2FYRYGE0ABQAGAQECMTVCSzQ3RENJT0YxU0xMVVc5UAADfgAAAAQAAAhHNEk0R0ZKWEpCOUFUWjNQVFgxAAlMVkRCSkFXOEJJNVlTUzFRVUJHAAoACwFub25lAAJub25lAAMBBAEAAiMwMDAwMDAAA8gBAAUBAQIjMDAwMDAwAAPIAQAAAAFLOUpOMjNQMjRLUUNHSzlVNzVBAAJIU1laUFpXMTY2OVU4MjFCV1lQAAMEAUZTMDBEWFYwVDlSMVg5Rko0UUUAAgAAAVFZNVM4S01PNUhMSlVGMFAwMEsAAgAAATE1Qks0N0RDSU9GMVNMTFVXOVAAAgExMTUyIENCWCBQdXJraW5qZSBHYWJhXzEAAAFDQkdDMFUzMFZWOUpQUjYwVEpVAAIAAAQBAAKEUL8fg4IJfwOEoBqHhMQ92QQyTlFUSUU3VEFNUDhQUUFITzRQAAWBr6ZKgemsDoGggUeAktXoBgAHAAAFAAYBAQIxNUJLNDdEQ0lPRjFTTExVVzlQAAN%2BAAAABAAACFZGT0ZZUEZRR1JLVURRVVozRkYACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAVRMT0tXQ0w5NVJVMDNEOVBFVEcAAjczR1ZURFhERUdFMjdNMlhKTVQAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAgMA" xsd:string {name="Reference data on Allen Brain Cell Atlas"} property_value: seeAlso "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_28.h5ad" xsd:string {comment="Warning large data file!", name="h5ad data file for CS20230722_CLAS_28"} [Term] id: CL:4301583 name: CBX Purkinje Gaba_2 Purkinje cell (Mmus) def: "A Purkinje cell of the Mus musculus brain. Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Supertype:1153 CBX Purkinje Gaba_2." [https://doi.org/10.1038/s41586-023-06812-z] comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions. subset: mouse_subset synonym: "1153 CBX Purkinje Gaba_2" EXACT [] is_a: CL:4300353 ! Purkinje cell (Mmus) property_value: CLM:0010003 CLM:5016793 property_value: IAO:0000028 "CBX Purkinje Gaba_2 (Mmus)" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIBMTE1MyBDQlggUHVya2luamUgR2FiYV8yAAABQ0JHQzBVMzBWVjlKUFI2MFRKVQACAAAEAQECgazGjoGWFSADhGpN%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%2BAAAABAAACFZGT0ZZUEZRR1JLVURRVVozRkYACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAVRMT0tXQ0w5NVJVMDNEOVBFVEcAAjczR1ZURFhERUdFMjdNMlhKTVQAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAgMA" xsd:string {name="Reference data on Allen Brain Cell Atlas"} property_value: seeAlso "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_28.h5ad" xsd:string {comment="Warning large data file!", name="h5ad data file for CS20230722_CLAS_28"} [Term] id: CL:4301584 name: CB Granule Glut_1 cerebellar granule cell (Mmus) def: "A cerebellar granule cell of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Gabra6 (Mmus), Lmx1a (Mmus). Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Supertype:1154 CB Granule Glut_1." [https://doi.org/10.1038/s41586-023-06812-z] comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions. subset: mouse_subset synonym: "1154 CB Granule Glut_1" EXACT [] is_a: CL:4300354 ! cerebellar granule cell (Mmus) property_value: CLM:0010003 CLM:5001574 {STATO:0000663="0.35714287"} property_value: CLM:0010003 CLM:5016794 property_value: IAO:0000028 "CB Granule Glut_1 (Mmus)" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIBMTE1NCBDQiBHcmFudWxlIEdsdXRfMQAAAUNCR0MwVTMwVlY5SlBSNjBUSlUAAgAABAEBAoGsxo6BlhUgA4RqTf2EWBhNAAUABgEBAjE1Qks0N0RDSU9GMVNMTFVXOVAAA34AAAAEAAAIRzRJNEdGSlhKQjlBVFozUFRYMQAJTFZEQkpBVzhCSTVZU1MxUVVCRwAKAAsBbm9uZQACbm9uZQADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAABSzlKTjIzUDI0S1FDR0s5VTc1QQACSFNZWlBaVzE2NjlVODIxQldZUAADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIBMTE1NCBDQiBHcmFudWxlIEdsdXRfMQAAAUNCR0MwVTMwVlY5SlBSNjBUSlUAAgAABAEAAoRQvx%2BDggl%2FA4SgGoeExD3ZBDJOUVRJRTdUQU1QOFBRQUhPNFAABYGvpkqB6awOgaCBR4CS1egGAAcAAAUABgEBAjE1Qks0N0RDSU9GMVNMTFVXOVAAA34AAAAEAAAIVkZPRllQRlFHUktVRFFVWjNGRgAJTFZEQkpBVzhCSTVZU1MxUVVCRwAKAAsBVExPS1dDTDk1UlUwM0Q5UEVURwACNzNHVlREWERFR0UyN00yWEpNVAADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAACAwA%3D" xsd:string {name="Reference data on Allen Brain Cell Atlas"} property_value: seeAlso "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_29.h5ad" xsd:string {comment="Warning large data file!", name="h5ad data file for CS20230722_CLAS_29"} [Term] id: CL:4301585 name: CB Granule Glut_2 cerebellar granule cell (Mmus) def: "A cerebellar granule cell of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Gabra6 (Mmus), Gap43 (Mmus), Rab37 (Mmus). Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Supertype:1155 CB Granule Glut_2." [https://doi.org/10.1038/s41586-023-06812-z] comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions. subset: mouse_subset synonym: "1155 CB Granule Glut_2" EXACT [] is_a: CL:4300354 ! cerebellar granule cell (Mmus) property_value: CLM:0010003 CLM:5001575 {STATO:0000663="0.24193548"} property_value: CLM:0010003 CLM:5016795 property_value: IAO:0000028 "CB Granule Glut_2 (Mmus)" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#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%2BDggl%2FA4SgGoeExD3ZBDJOUVRJRTdUQU1QOFBRQUhPNFAABYGvpkqB6awOgaCBR4CS1egGAAcAAAUABgEBAjE1Qks0N0RDSU9GMVNMTFVXOVAAA34AAAAEAAAIVkZPRllQRlFHUktVRFFVWjNGRgAJTFZEQkpBVzhCSTVZU1MxUVVCRwAKAAsBVExPS1dDTDk1UlUwM0Q5UEVURwACNzNHVlREWERFR0UyN00yWEpNVAADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAACAwA%3D" xsd:string {name="Reference data on Allen Brain Cell Atlas"} property_value: seeAlso "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_29.h5ad" xsd:string {comment="Warning large data file!", name="h5ad data file for CS20230722_CLAS_29"} [Term] id: CL:4301586 name: unipolar brush cell (Mmus) def: "A unipolar brush cell of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Sln (Mmus), Lmx1a (Mmus). Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Supertype:1156 DCO UBC Glut_1." [https://doi.org/10.1038/s41586-023-06812-z] comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions. subset: mouse_subset synonym: "1156 DCO UBC Glut_1" EXACT [] synonym: "315 DCO UBC Glut" EXACT [] is_a: CL:4023161 ! unipolar brush cell is_a: CL:4300029 ! cerebellar glutamatergic neuron (Mmus) property_value: CLM:0010003 CLM:5001576 {STATO:0000663="0.5875"} property_value: CLM:0010003 CLM:5007975 {STATO:0000663="0.875"} property_value: CLM:0010003 CLM:5016796 property_value: IAO:0000028 "DCO UBC Glut (Mmus)" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIBMzE1IERDTyBVQkMgR2x1dAAAATE1Qks0N0RDSU9GMVNMTFVXOVAAAgAAAUNCR0MwVTMwVlY5SlBSNjBUSlUAAgAABAEBAoGsxo6BlhUgA4RqTf2EWBhNAAUABgEBAlFZNVM4S01PNUhMSlVGMFAwMEsAA34AAAAEAAAIRzRJNEdGSlhKQjlBVFozUFRYMQAJTFZEQkpBVzhCSTVZU1MxUVVCRwAKAAsBbm9uZQACbm9uZQADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAABSzlKTjIzUDI0S1FDR0s5VTc1QQACSFNZWlBaVzE2NjlVODIxQldZUAADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIBMzE1IERDTyBVQkMgR2x1dAAAATE1Qks0N0RDSU9GMVNMTFVXOVAAAgAAAUNCR0MwVTMwVlY5SlBSNjBUSlUAAgAABAEAAoRQvx%2BDggl%2FA4SgGoeExD3ZBDJOUVRJRTdUQU1QOFBRQUhPNFAABYGvpkqB6awOgaCBR4CS1egGAAcAAAUABgEBAlFZNVM4S01PNUhMSlVGMFAwMEsAA34AAAAEAAAIVkZPRllQRlFHUktVRFFVWjNGRgAJTFZEQkpBVzhCSTVZU1MxUVVCRwAKAAsBVExPS1dDTDk1UlUwM0Q5UEVURwACNzNHVlREWERFR0UyN00yWEpNVAADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAACAwA%3D" xsd:string {name="Reference data on Allen Brain Cell Atlas"} property_value: seeAlso "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_29.h5ad" xsd:string {comment="Warning large data file!", name="h5ad data file for CS20230722_CLAS_29"} [Term] id: CL:4301589 name: Astro-NT NN_1 astrocyte (Mmus) def: "A astrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Gfap (Mmus), Lhfpl3 (Mmus), Gria1 (Mmus), Hopx (Mmus). Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Supertype:1159 Astro-NT NN_1." [https://doi.org/10.1038/s41586-023-06812-z] comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions. subset: human_subset subset: mouse_subset synonym: "1159 Astro-NT NN_1" EXACT [] is_a: CL:4300358 ! subcortical astrocyte (Mmus) property_value: CLM:0010003 CLM:5001579 {STATO:0000663="0.14610389"} property_value: CLM:0010003 CLM:5016799 property_value: IAO:0000028 "Astro-NT NN_1 (Mmus)" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIBMTE1OSBBc3Ryby1OVCBOTl8xAAABQ0JHQzBVMzBWVjlKUFI2MFRKVQACAAAEAQECgazGjoGWFSADhGpN%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%2BAAAABAAACFZGT0ZZUEZRR1JLVURRVVozRkYACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAVRMT0tXQ0w5NVJVMDNEOVBFVEcAAjczR1ZURFhERUdFMjdNMlhKTVQAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAgMA" xsd:string {name="Reference data on Allen Brain Cell Atlas"} property_value: seeAlso "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_30.h5ad" xsd:string {comment="Warning large data file!", name="h5ad data file for CS20230722_CLAS_30"} [Term] id: CL:4301590 name: Astro-NT NN_2 astrocyte (Mmus) def: "A astrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Gja1 (Mmus), A330076C08Rik (Mmus), Itih3 (Mmus), Gria2 (Mmus). Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Supertype:1160 Astro-NT NN_2." [https://doi.org/10.1038/s41586-023-06812-z] comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions. subset: human_subset subset: mouse_subset synonym: "1160 Astro-NT NN_2" EXACT [] is_a: CL:4300358 ! subcortical astrocyte (Mmus) property_value: CLM:0010003 CLM:5001580 {STATO:0000663="0.3472222"} property_value: CLM:0010003 CLM:5016800 property_value: IAO:0000028 "Astro-NT NN_2 (Mmus)" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIBMTE2MCBBc3Ryby1OVCBOTl8yAAABQ0JHQzBVMzBWVjlKUFI2MFRKVQACAAAEAQECgazGjoGWFSADhGpN%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%2BAAAABAAACFZGT0ZZUEZRR1JLVURRVVozRkYACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAVRMT0tXQ0w5NVJVMDNEOVBFVEcAAjczR1ZURFhERUdFMjdNMlhKTVQAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAgMA" xsd:string {name="Reference data on Allen Brain Cell Atlas"} property_value: seeAlso "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_30.h5ad" xsd:string {comment="Warning large data file!", name="h5ad data file for CS20230722_CLAS_30"} [Term] id: CL:4301591 name: Astro-TE NN_1 astrocyte (Mmus) def: "A astrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Myoc (Mmus), Camk2a (Mmus). Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Supertype:1161 Astro-TE NN_1." [https://doi.org/10.1038/s41586-023-06812-z] comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions. subset: human_subset subset: mouse_subset synonym: "1161 Astro-TE NN_1" EXACT [] is_a: CL:4300359 ! astrocyte of cerebrum (Mmus) property_value: CLM:0010003 CLM:5001581 {STATO:0000663="0.19067797"} property_value: CLM:0010003 CLM:5016801 property_value: IAO:0000028 "Astro-TE NN_1 (Mmus)" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIBMTE2MSBBc3Ryby1URSBOTl8xAAABQ0JHQzBVMzBWVjlKUFI2MFRKVQACAAAEAQECgazGjoGWFSADhGpN%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%2BAAAABAAACFZGT0ZZUEZRR1JLVURRVVozRkYACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAVRMT0tXQ0w5NVJVMDNEOVBFVEcAAjczR1ZURFhERUdFMjdNMlhKTVQAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAgMA" xsd:string {name="Reference data on Allen Brain Cell Atlas"} property_value: seeAlso "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_30.h5ad" xsd:string {comment="Warning large data file!", name="h5ad data file for CS20230722_CLAS_30"} [Term] id: CL:4301592 name: Astro-TE NN_2 astrocyte (Mmus) def: "A astrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Hepacam (Mmus), E330013P04Rik (Mmus). Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Supertype:1162 Astro-TE NN_2." [https://doi.org/10.1038/s41586-023-06812-z] comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions. subset: human_subset subset: mouse_subset synonym: "1162 Astro-TE NN_2" EXACT [] is_a: CL:4300359 ! astrocyte of cerebrum (Mmus) property_value: CLM:0010003 CLM:5001582 {STATO:0000663="0.5882353"} property_value: CLM:0010003 CLM:5016802 property_value: IAO:0000028 "Astro-TE NN_2 (Mmus)" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIBMTE2MiBBc3Ryby1URSBOTl8yAAABQ0JHQzBVMzBWVjlKUFI2MFRKVQACAAAEAQECgazGjoGWFSADhGpN%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%2BAAAABAAACFZGT0ZZUEZRR1JLVURRVVozRkYACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAVRMT0tXQ0w5NVJVMDNEOVBFVEcAAjczR1ZURFhERUdFMjdNMlhKTVQAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAgMA" xsd:string {name="Reference data on Allen Brain Cell Atlas"} property_value: seeAlso "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_30.h5ad" xsd:string {comment="Warning large data file!", name="h5ad data file for CS20230722_CLAS_30"} [Term] id: CL:4301593 name: Astro-TE NN_3 astrocyte (Mmus) def: "A astrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Gja1 (Mmus), Grin2c (Mmus), Dcc (Mmus), Slc7a10 (Mmus). Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Supertype:1163 Astro-TE NN_3." [https://doi.org/10.1038/s41586-023-06812-z] comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions. subset: human_subset subset: mouse_subset synonym: "1163 Astro-TE NN_3" EXACT [] is_a: CL:4300359 ! astrocyte of cerebrum (Mmus) property_value: CLM:0010003 CLM:5001583 {STATO:0000663="0.33450705"} property_value: CLM:0010003 CLM:5016803 property_value: IAO:0000028 "Astro-TE NN_3 (Mmus)" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIBMTE2MyBBc3Ryby1URSBOTl8zAAABQ0JHQzBVMzBWVjlKUFI2MFRKVQACAAAEAQECgazGjoGWFSADhGpN%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%2BAAAABAAACFZGT0ZZUEZRR1JLVURRVVozRkYACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAVRMT0tXQ0w5NVJVMDNEOVBFVEcAAjczR1ZURFhERUdFMjdNMlhKTVQAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAgMA" xsd:string {name="Reference data on Allen Brain Cell Atlas"} property_value: seeAlso "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_30.h5ad" xsd:string {comment="Warning large data file!", name="h5ad data file for CS20230722_CLAS_30"} [Term] id: CL:4301595 name: Astro-TE NN_5 astrocyte (Mmus) def: "A astrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Gja1 (Mmus), Thbs4 (Mmus), Kcnk10 (Mmus), Pak1 (Mmus). Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Supertype:1165 Astro-TE NN_5." [https://doi.org/10.1038/s41586-023-06812-z] comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions. subset: human_subset subset: mouse_subset synonym: "1165 Astro-TE NN_5" EXACT [] is_a: CL:4300359 ! astrocyte of cerebrum (Mmus) property_value: CLM:0010003 CLM:5001585 {STATO:0000663="0.048076924"} property_value: CLM:0010003 CLM:5016805 property_value: IAO:0000028 "Astro-TE NN_5 (Mmus)" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIBMTE2NSBBc3Ryby1URSBOTl81AAABQ0JHQzBVMzBWVjlKUFI2MFRKVQACAAAEAQECgazGjoGWFSADhGpN%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%2BAAAABAAACFZGT0ZZUEZRR1JLVURRVVozRkYACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAVRMT0tXQ0w5NVJVMDNEOVBFVEcAAjczR1ZURFhERUdFMjdNMlhKTVQAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAgMA" xsd:string {name="Reference data on Allen Brain Cell Atlas"} property_value: seeAlso "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_30.h5ad" xsd:string {comment="Warning large data file!", name="h5ad data file for CS20230722_CLAS_30"} [Term] id: CL:4301596 name: Astro-OLF NN_1 astrocyte (Mmus) def: "A astrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Aqp4 (Mmus), Prss23 (Mmus), Igfbp2 (Mmus). Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Supertype:1166 Astro-OLF NN_1." [https://doi.org/10.1038/s41586-023-06812-z] comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions. subset: human_subset subset: mouse_subset synonym: "1166 Astro-OLF NN_1" EXACT [] is_a: CL:4300360 ! olfactory areas astrocyte (Mmus) property_value: CLM:0010003 CLM:5001586 {STATO:0000663="0.5113636"} property_value: CLM:0010003 CLM:5016806 property_value: IAO:0000028 "Astro-OLF NN_1 (Mmus)" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#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%2BDggl%2FA4SgGoeExD3ZBDJOUVRJRTdUQU1QOFBRQUhPNFAABYGvpkqB6awOgaCBR4CS1egGAAcAAAUABgEBAjE1Qks0N0RDSU9GMVNMTFVXOVAAA34AAAAEAAAIVkZPRllQRlFHUktVRFFVWjNGRgAJTFZEQkpBVzhCSTVZU1MxUVVCRwAKAAsBVExPS1dDTDk1UlUwM0Q5UEVURwACNzNHVlREWERFR0UyN00yWEpNVAADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAACAwA%3D" xsd:string {name="Reference data on Allen Brain Cell Atlas"} property_value: seeAlso "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_30.h5ad" xsd:string {comment="Warning large data file!", name="h5ad data file for CS20230722_CLAS_30"} [Term] id: CL:4301597 name: Astro-OLF NN_2 astrocyte (Mmus) def: "A astrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Gja1 (Mmus), Hs3st3a1 (Mmus), Slco1c1 (Mmus). Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Supertype:1167 Astro-OLF NN_2." [https://doi.org/10.1038/s41586-023-06812-z] comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions. subset: human_subset subset: mouse_subset synonym: "1167 Astro-OLF NN_2" EXACT [] is_a: CL:4300360 ! olfactory areas astrocyte (Mmus) property_value: CLM:0010003 CLM:5001587 {STATO:0000663="0.37280703"} property_value: CLM:0010003 CLM:5016807 property_value: IAO:0000028 "Astro-OLF NN_2 (Mmus)" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#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%2BDggl%2FA4SgGoeExD3ZBDJOUVRJRTdUQU1QOFBRQUhPNFAABYGvpkqB6awOgaCBR4CS1egGAAcAAAUABgEBAjE1Qks0N0RDSU9GMVNMTFVXOVAAA34AAAAEAAAIVkZPRllQRlFHUktVRFFVWjNGRgAJTFZEQkpBVzhCSTVZU1MxUVVCRwAKAAsBVExPS1dDTDk1UlUwM0Q5UEVURwACNzNHVlREWERFR0UyN00yWEpNVAADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAACAwA%3D" xsd:string {name="Reference data on Allen Brain Cell Atlas"} property_value: seeAlso "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_30.h5ad" xsd:string {comment="Warning large data file!", name="h5ad data file for CS20230722_CLAS_30"} [Term] id: CL:4301598 name: Astro-OLF NN_3 astrocyte (Mmus) def: "A astrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Ednrb (Mmus), Hs3st3a1 (Mmus), C230072F16Rik (Mmus), Gria2 (Mmus). Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Supertype:1168 Astro-OLF NN_3." [https://doi.org/10.1038/s41586-023-06812-z] comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions. subset: human_subset subset: mouse_subset synonym: "1168 Astro-OLF NN_3" EXACT [] is_a: CL:4300360 ! olfactory areas astrocyte (Mmus) property_value: CLM:0010003 CLM:5001588 {STATO:0000663="0.1724138"} property_value: CLM:0010003 CLM:5016808 property_value: IAO:0000028 "Astro-OLF NN_3 (Mmus)" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#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%2BDggl%2FA4SgGoeExD3ZBDJOUVRJRTdUQU1QOFBRQUhPNFAABYGvpkqB6awOgaCBR4CS1egGAAcAAAUABgEBAjE1Qks0N0RDSU9GMVNMTFVXOVAAA34AAAAEAAAIVkZPRllQRlFHUktVRFFVWjNGRgAJTFZEQkpBVzhCSTVZU1MxUVVCRwAKAAsBVExPS1dDTDk1UlUwM0Q5UEVURwACNzNHVlREWERFR0UyN00yWEpNVAADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAACAwA%3D" xsd:string {name="Reference data on Allen Brain Cell Atlas"} property_value: seeAlso "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_30.h5ad" xsd:string {comment="Warning large data file!", name="h5ad data file for CS20230722_CLAS_30"} [Term] id: CL:4301602 name: Tanycyte NN_1 tanycyte (Mmus) def: "A tanycyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Cnmd (Mmus), Lpl (Mmus). Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Supertype:1172 Tanycyte NN_1." [https://doi.org/10.1038/s41586-023-06812-z] comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions. subset: human_subset subset: mouse_subset synonym: "1172 Tanycyte NN_1" EXACT [] is_a: CL:4300362 ! tanycyte (Mmus) property_value: CLM:0010003 CLM:5001592 {STATO:0000663="0.390625"} property_value: CLM:0010003 CLM:5016812 property_value: IAO:0000028 "Tanycyte NN_1 (Mmus)" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIBMTE3MiBUYW55Y3l0ZSBOTl8xAAABQ0JHQzBVMzBWVjlKUFI2MFRKVQACAAAEAQECgazGjoGWFSADhGpN%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%2BAAAABAAACFZGT0ZZUEZRR1JLVURRVVozRkYACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAVRMT0tXQ0w5NVJVMDNEOVBFVEcAAjczR1ZURFhERUdFMjdNMlhKTVQAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAgMA" xsd:string {name="Reference data on Allen Brain Cell Atlas"} property_value: seeAlso "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_30.h5ad" xsd:string {comment="Warning large data file!", name="h5ad data file for CS20230722_CLAS_30"} [Term] id: CL:4301603 name: Tanycyte NN_2 tanycyte (Mmus) def: "A tanycyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Gpr50 (Mmus), Ccdc170 (Mmus), Nkx2-4 (Mmus). Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Supertype:1173 Tanycyte NN_2." [https://doi.org/10.1038/s41586-023-06812-z] comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions. subset: human_subset subset: mouse_subset synonym: "1173 Tanycyte NN_2" EXACT [] is_a: CL:4300362 ! tanycyte (Mmus) property_value: CLM:0010003 CLM:5001593 {STATO:0000663="0.54086536"} property_value: CLM:0010003 CLM:5016813 property_value: IAO:0000028 "Tanycyte NN_2 (Mmus)" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIBMTE3MyBUYW55Y3l0ZSBOTl8yAAABQ0JHQzBVMzBWVjlKUFI2MFRKVQACAAAEAQECgazGjoGWFSADhGpN%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%2BAAAABAAACFZGT0ZZUEZRR1JLVURRVVozRkYACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAVRMT0tXQ0w5NVJVMDNEOVBFVEcAAjczR1ZURFhERUdFMjdNMlhKTVQAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAgMA" xsd:string {name="Reference data on Allen Brain Cell Atlas"} property_value: seeAlso "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_30.h5ad" xsd:string {comment="Warning large data file!", name="h5ad data file for CS20230722_CLAS_30"} [Term] id: CL:4301608 name: choroid plexus epithelial cell (Mmus) def: "A choroid plexus epithelial cell of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of 2900040C04Rik (Mmus). Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Supertype:1178 CHOR NN_1." [https://doi.org/10.1038/s41586-023-06812-z] comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions. subset: human_subset subset: mouse_subset synonym: "1178 CHOR NN_1" EXACT [] synonym: "325 CHOR NN" EXACT [] is_a: CL:0000706 ! choroid plexus epithelial cell property_value: CLM:0010003 CLM:5001598 {STATO:0000663="0.99385244"} property_value: CLM:0010003 CLM:5007985 {STATO:0000663="0.9857724"} property_value: CLM:0010003 CLM:5016818 property_value: IAO:0000028 "CHOR NN (Mmus)" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIBMzI1IENIT1IgTk4AAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIAAAFDQkdDMFUzMFZWOUpQUjYwVEpVAAIAAAQBAQKBrMaOgZYVIAOEak39hFgYTQAFAAYBAQJRWTVTOEtNTzVITEpVRjBQMDBLAAN%2BAAAABAAACEc0STRHRkpYSkI5QVRaM1BUWDEACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAW5vbmUAAm5vbmUAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAUs5Sk4yM1AyNEtRQ0dLOVU3NUEAAkhTWVpQWlcxNjY5VTgyMUJXWVAAAwQBRlMwMERYVjBUOVIxWDlGSjRRRQACAAABUVk1UzhLTU81SExKVUYwUDAwSwACATMyNSBDSE9SIE5OAAABMTVCSzQ3RENJT0YxU0xMVVc5UAACAAABQ0JHQzBVMzBWVjlKUFI2MFRKVQACAAAEAQAChFC%2FH4OCCX8DhKAah4TEPdkEMk5RVElFN1RBTVA4UFFBSE80UAAFga%2BmSoHprA6BoIFHgJLV6AYABwAABQAGAQECUVk1UzhLTU81SExKVUYwUDAwSwADfgAAAAQAAAhWRk9GWVBGUUdSS1VEUVVaM0ZGAAlMVkRCSkFXOEJJNVlTUzFRVUJHAAoACwFUTE9LV0NMOTVSVTAzRDlQRVRHAAI3M0dWVERYREVHRTI3TTJYSk1UAAMBBAEAAiMwMDAwMDAAA8gBAAUBAQIjMDAwMDAwAAPIAQAAAAIDAA%3D%3D" xsd:string {name="Reference data on Allen Brain Cell Atlas"} property_value: seeAlso "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_30.h5ad" xsd:string {comment="Warning large data file!", name="h5ad data file for CS20230722_CLAS_30"} [Term] id: CL:4301611 name: commited oligodendrocyte precursor (Mmus) def: "A committed oligodendrocyte precursor of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Gpr17 (Mmus), Bmp4 (Mmus). Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Supertype:1181 COP NN_1." [https://doi.org/10.1038/s41586-023-06812-z, https://doi.org/10.1126/science.aaf6463] comment: Rationale for assigning this type to reference data: Mapping of this cell set to a differentiation-committed oligodendrocyte is supported by spatial transcriptomic evidence and specific expression of Gpr17, Bmp4, Neu4, Fyn in the context of oligodendrocyte lineage cells. Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions. {xref="https://doi.org/10.1126/science.aaf6463"} subset: mouse_subset synonym: "1181 COP NN_1" EXACT [] is_a: CL:4023059 ! committed oligodendrocyte precursor is_a: CL:4300367 ! oligodendrocyte (Mmus) property_value: CLM:0010003 CLM:5001601 {STATO:0000663="0.8684739"} property_value: CLM:0010003 CLM:5016821 property_value: CLM:0010003 CLM:5024421 property_value: IAO:0000028 "COP NN_1 (Mmus)" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#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%2BDggl%2FA4SgGoeExD3ZBDJOUVRJRTdUQU1QOFBRQUhPNFAABYGvpkqB6awOgaCBR4CS1egGAAcAAAUABgEBAjE1Qks0N0RDSU9GMVNMTFVXOVAAA34AAAAEAAAIVkZPRllQRlFHUktVRFFVWjNGRgAJTFZEQkpBVzhCSTVZU1MxUVVCRwAKAAsBVExPS1dDTDk1UlUwM0Q5UEVURwACNzNHVlREWERFR0UyN00yWEpNVAADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAACAwA%3D" xsd:string {name="Reference data on Allen Brain Cell Atlas"} property_value: seeAlso "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_31.h5ad" xsd:string {comment="Warning large data file!", name="h5ad data file for CS20230722_CLAS_31"} [Term] id: CL:4301612 name: newly formed oligodendrocyte (Mmus) def: "A newly formed oligodendrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of 9630013A20Rik (Mmus), Ptprb (Mmus). Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Supertype:1182 NFOL NN_2." [https://doi.org/10.1038/s41586-023-06812-z, https://doi.org/10.1126/science.aaf6463] comment: Rationale for assigning this type to reference data: Mapping of this cell set to a newly formed oligodendrocyte is supported by spatial transcriptomic evidence and specific expression of Tcf7l2, Klk6, Cemip2, Casr in the context of oligodendrocyte lineage cells. Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions. {xref="https://doi.org/10.1126/science.aaf6463"} subset: mouse_subset synonym: "1182 NFOL NN_2" EXACT [] is_a: CL:4072001 ! newly formed oligodendrocyte is_a: CL:4300367 ! oligodendrocyte (Mmus) property_value: CLM:0010003 CLM:5001602 {STATO:0000663="0.6304985"} property_value: CLM:0010003 CLM:5016822 property_value: CLM:0010003 CLM:5024422 property_value: IAO:0000028 "NFOL NN_2 (Mmus)" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIBMTE4MiBORk9MIE5OXzIAAAFDQkdDMFUzMFZWOUpQUjYwVEpVAAIAAAQBAQKBrMaOgZYVIAOEak39hFgYTQAFAAYBAQIxNUJLNDdEQ0lPRjFTTExVVzlQAAN%2BAAAABAAACEc0STRHRkpYSkI5QVRaM1BUWDEACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAW5vbmUAAm5vbmUAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAUs5Sk4yM1AyNEtRQ0dLOVU3NUEAAkhTWVpQWlcxNjY5VTgyMUJXWVAAAwQBRlMwMERYVjBUOVIxWDlGSjRRRQACAAABUVk1UzhLTU81SExKVUYwUDAwSwACAAABMTVCSzQ3RENJT0YxU0xMVVc5UAACATExODIgTkZPTCBOTl8yAAABQ0JHQzBVMzBWVjlKUFI2MFRKVQACAAAEAQAChFC%2FH4OCCX8DhKAah4TEPdkEMk5RVElFN1RBTVA4UFFBSE80UAAFga%2BmSoHprA6BoIFHgJLV6AYABwAABQAGAQECMTVCSzQ3RENJT0YxU0xMVVc5UAADfgAAAAQAAAhWRk9GWVBGUUdSS1VEUVVaM0ZGAAlMVkRCSkFXOEJJNVlTUzFRVUJHAAoACwFUTE9LV0NMOTVSVTAzRDlQRVRHAAI3M0dWVERYREVHRTI3TTJYSk1UAAMBBAEAAiMwMDAwMDAAA8gBAAUBAQIjMDAwMDAwAAPIAQAAAAIDAA%3D%3D" xsd:string {name="Reference data on Allen Brain Cell Atlas"} property_value: seeAlso "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_31.h5ad" xsd:string {comment="Warning large data file!", name="h5ad data file for CS20230722_CLAS_31"} [Term] id: CL:4301613 name: myelin-forming oligodendrocyte (Mmus) def: "A myelin-forming oligodendrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Cldn11 (Mmus), Sec14l5 (Mmus), 9630013A20Rik (Mmus). Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Supertype:1183 MFOL NN_3." [https://doi.org/10.1038/s41586-023-06812-z, https://doi.org/10.1126/science.aaf6463] comment: Rationale for assigning this type to reference data: Mapping of this cell set to a myelin-forming oligodendrocyte is supported by spatial transcriptomic evidence and specific expression of Ctps, Cldn11 in the context of oligodendrocyte lineage cells. Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions. {xref="https://doi.org/10.1126/science.aaf6463"} subset: mouse_subset synonym: "1183 MFOL NN_3" EXACT [] is_a: CL:4072002 ! myelin-forming oligodendrocyte is_a: CL:4300367 ! oligodendrocyte (Mmus) property_value: CLM:0010003 CLM:5001603 {STATO:0000663="0.49418604"} property_value: CLM:0010003 CLM:5016823 property_value: CLM:0010003 CLM:5024423 property_value: IAO:0000028 "MFOL NN_3 (Mmus)" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIBMTE4MyBNRk9MIE5OXzMAAAFDQkdDMFUzMFZWOUpQUjYwVEpVAAIAAAQBAQKBrMaOgZYVIAOEak39hFgYTQAFAAYBAQIxNUJLNDdEQ0lPRjFTTExVVzlQAAN%2BAAAABAAACEc0STRHRkpYSkI5QVRaM1BUWDEACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAW5vbmUAAm5vbmUAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAUs5Sk4yM1AyNEtRQ0dLOVU3NUEAAkhTWVpQWlcxNjY5VTgyMUJXWVAAAwQBRlMwMERYVjBUOVIxWDlGSjRRRQACAAABUVk1UzhLTU81SExKVUYwUDAwSwACAAABMTVCSzQ3RENJT0YxU0xMVVc5UAACATExODMgTUZPTCBOTl8zAAABQ0JHQzBVMzBWVjlKUFI2MFRKVQACAAAEAQAChFC%2FH4OCCX8DhKAah4TEPdkEMk5RVElFN1RBTVA4UFFBSE80UAAFga%2BmSoHprA6BoIFHgJLV6AYABwAABQAGAQECMTVCSzQ3RENJT0YxU0xMVVc5UAADfgAAAAQAAAhWRk9GWVBGUUdSS1VEUVVaM0ZGAAlMVkRCSkFXOEJJNVlTUzFRVUJHAAoACwFUTE9LV0NMOTVSVTAzRDlQRVRHAAI3M0dWVERYREVHRTI3TTJYSk1UAAMBBAEAAiMwMDAwMDAAA8gBAAUBAQIjMDAwMDAwAAPIAQAAAAIDAA%3D%3D" xsd:string {name="Reference data on Allen Brain Cell Atlas"} property_value: seeAlso "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_31.h5ad" xsd:string {comment="Warning large data file!", name="h5ad data file for CS20230722_CLAS_31"} [Term] id: CL:4301614 name: mature myelinating oligodendrocyte (Mmus) def: "A mature myelinating oligodendrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Cldn11 (Mmus), Anln (Mmus). Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Supertype:1184 MOL NN_4." [https://doi.org/10.1038/s41586-023-06812-z, https://doi.org/10.1126/science.aaf6463] comment: Rationale for assigning this type to reference data: Mapping of this cell set to a mature myelinating oligodendrocyte is supported by spatial transcriptomic evidence and specific expression of Klk6 in the context of oligodendrocyte lineage cells. Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions. {xref="https://doi.org/10.1126/science.aaf6463"} subset: mouse_subset synonym: "1184 MOL NN_4" EXACT [] is_a: CL:4072003 ! mature myelinating oligodendrocyte is_a: CL:4300367 ! oligodendrocyte (Mmus) property_value: CLM:0010003 CLM:5001604 {STATO:0000663="0.7853026"} property_value: CLM:0010003 CLM:5016824 property_value: CLM:0010003 CLM:5024424 property_value: IAO:0000028 "MOL NN_4 (Mmus)" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#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%2BDggl%2FA4SgGoeExD3ZBDJOUVRJRTdUQU1QOFBRQUhPNFAABYGvpkqB6awOgaCBR4CS1egGAAcAAAUABgEBAjE1Qks0N0RDSU9GMVNMTFVXOVAAA34AAAAEAAAIVkZPRllQRlFHUktVRFFVWjNGRgAJTFZEQkpBVzhCSTVZU1MxUVVCRwAKAAsBVExPS1dDTDk1UlUwM0Q5UEVURwACNzNHVlREWERFR0UyN00yWEpNVAADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAACAwA%3D" xsd:string {name="Reference data on Allen Brain Cell Atlas"} property_value: seeAlso "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_31.h5ad" xsd:string {comment="Warning large data file!", name="h5ad data file for CS20230722_CLAS_31"} [Term] id: CL:4301615 name: olfactory ensheathing cell (Mmus) def: "A olfactory ensheathing cell of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Apod (Mmus), Npy (Mmus). Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Supertype:1185 OEC NN_1." [https://doi.org/10.1038/s41586-023-06812-z] comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions. subset: mouse_subset synonym: "1185 OEC NN_1" EXACT [] synonym: "32 OEC" EXACT [] synonym: "328 OEC NN" EXACT [] is_a: CL:0011028 ! olfactory ensheathing cell relationship: RO:0002162 NCBITaxon:10090 ! in taxon Mus musculus property_value: CLM:0010003 CLM:5001605 property_value: CLM:0010003 CLM:5007652 {STATO:0000663="0.8990148"} property_value: CLM:0010003 CLM:5007988 {STATO:0000663="0.9126984"} property_value: CLM:0010003 CLM:5016825 property_value: IAO:0000028 "OEC (Mmus)" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIBMzIgT0VDAAABUVk1UzhLTU81SExKVUYwUDAwSwACAAABMTVCSzQ3RENJT0YxU0xMVVc5UAACAAABQ0JHQzBVMzBWVjlKUFI2MFRKVQACAAAEAQECgazGjoGWFSADhGpN%2FYRYGE0ABQAGAQECRlMwMERYVjBUOVIxWDlGSjRRRQADfgAAAAQAAAhHNEk0R0ZKWEpCOUFUWjNQVFgxAAlMVkRCSkFXOEJJNVlTUzFRVUJHAAoACwFub25lAAJub25lAAMBBAEAAiMwMDAwMDAAA8gBAAUBAQIjMDAwMDAwAAPIAQAAAAFLOUpOMjNQMjRLUUNHSzlVNzVBAAJIU1laUFpXMTY2OVU4MjFCV1lQAAMEAUZTMDBEWFYwVDlSMVg5Rko0UUUAAgEzMiBPRUMAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIAAAFDQkdDMFUzMFZWOUpQUjYwVEpVAAIAAAQBAAKEUL8fg4IJfwOEoBqHhMQ92QQyTlFUSUU3VEFNUDhQUUFITzRQAAWBr6ZKgemsDoGggUeAktXoBgAHAAAFAAYBAQJGUzAwRFhWMFQ5UjFYOUZKNFFFAAN%2BAAAABAAACFZGT0ZZUEZRR1JLVURRVVozRkYACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAVRMT0tXQ0w5NVJVMDNEOVBFVEcAAjczR1ZURFhERUdFMjdNMlhKTVQAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAgMA" xsd:string {name="Reference data on Allen Brain Cell Atlas"} property_value: seeAlso "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_32.h5ad" xsd:string {comment="Warning large data file!", name="h5ad data file for CS20230722_CLAS_32"} [Term] id: CL:4301616 name: arachnoid barrier cell (Mmus) def: "A arachnoid barrier cell of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Thbd (Mmus), Ccn3 (Mmus). Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Supertype:1186 ABC NN_1." [https://doi.org/10.1038/s41586-023-06812-z] comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions. subset: mouse_subset synonym: "1186 ABC NN_1" EXACT [] synonym: "329 ABC NN" EXACT [] is_a: CL:4023097 ! arachnoid barrier cell relationship: RO:0002162 NCBITaxon:10090 ! in taxon Mus musculus property_value: CLM:0010003 CLM:5001606 {STATO:0000663="0.8968254"} property_value: CLM:0010003 CLM:5007989 {STATO:0000663="0.93650794"} property_value: CLM:0010003 CLM:5016826 property_value: IAO:0000028 "ABC NN (Mmus)" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#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%2BDggl%2FA4SgGoeExD3ZBDJOUVRJRTdUQU1QOFBRQUhPNFAABYGvpkqB6awOgaCBR4CS1egGAAcAAAUABgEBAlFZNVM4S01PNUhMSlVGMFAwMEsAA34AAAAEAAAIVkZPRllQRlFHUktVRFFVWjNGRgAJTFZEQkpBVzhCSTVZU1MxUVVCRwAKAAsBVExPS1dDTDk1UlUwM0Q5UEVURwACNzNHVlREWERFR0UyN00yWEpNVAADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAACAwA%3D" xsd:string {name="Reference data on Allen Brain Cell Atlas"} property_value: seeAlso "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_33.h5ad" xsd:string {comment="Warning large data file!", name="h5ad data file for CS20230722_CLAS_33"} [Term] id: CL:4301625 name: border associated macrophage (Mmus) def: "A border associated macrophage of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Mrc1 (Mmus), Maf (Mmus). Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Supertype:1195 BAM NN_1." [https://doi.org/10.1038/s41586-023-06812-z] comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions. subset: mouse_subset synonym: "1195 BAM NN_1" EXACT [] synonym: "335 BAM NN" EXACT [] is_a: CL:4042003 ! border associated macrophage relationship: RO:0002162 NCBITaxon:10090 ! in taxon Mus musculus property_value: CLM:0010003 CLM:5001615 {STATO:0000663="0.9244792"} property_value: CLM:0010003 CLM:5007995 {STATO:0000663="0.982906"} property_value: CLM:0010003 CLM:5016835 property_value: IAO:0000028 "BAM NN (Mmus)" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#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%2BDggl%2FA4SgGoeExD3ZBDJOUVRJRTdUQU1QOFBRQUhPNFAABYGvpkqB6awOgaCBR4CS1egGAAcAAAUABgEBAlFZNVM4S01PNUhMSlVGMFAwMEsAA34AAAAEAAAIVkZPRllQRlFHUktVRFFVWjNGRgAJTFZEQkpBVzhCSTVZU1MxUVVCRwAKAAsBVExPS1dDTDk1UlUwM0Q5UEVURwACNzNHVlREWERFR0UyN00yWEpNVAADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAACAwA%3D" xsd:string {name="Reference data on Allen Brain Cell Atlas"} property_value: seeAlso "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_34.h5ad" xsd:string {comment="Warning large data file!", name="h5ad data file for CS20230722_CLAS_34"} [Term] id: CL:4304384 name: hypothalamic gonadotropin-releasing hormone neuron (Mmus) def: "A hypothalamic gonadotropin-releasing hormone neuron of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Gnrh1 (Mmus). It is glutamatergic (inferred from expression of Gad1, Slc17a6, Gad2). These cells are located in the Hypothalamus, Olfactory areas, Pallidum, brain , in or close to the regions: Lateral septal nucleus, rostral (rostroventral) part, Medial septal nucleus, Diagonal band nucleus . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:2564 HY Gnrh1 Glut_1." [https://doi.org/10.1038/s41586-023-06812-z] comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions. subset: mouse_subset synonym: "0628 HY Gnrh1 Glut_1" EXACT [] synonym: "142 HY Gnrh1 Glut" EXACT [] synonym: "15 HY Gnrh1 Glut" EXACT [] synonym: "2564 HY Gnrh1 Glut_1" EXACT [] is_a: CL:0000679 ! glutamatergic neuron is_a: CL:0011111 {evidence="http://identifiers.org/ncbigene/140919", evidence="http://identifiers.org/ncbigene/14415", evidence="http://identifiers.org/ncbigene/14417"} ! hypothalamic gonadotropin-releasing hormone neuron relationship: RO:0002162 NCBITaxon:10090 ! in taxon Mus musculus property_value: CLM:0010001 MBA:1097 {CLM:0010002="0.22", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF broad region."} property_value: CLM:0010001 MBA:258 {CLM:0010002="0.1", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF acronym region."} property_value: CLM:0010001 MBA:564 {CLM:0010002="0.25", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF acronym region."} property_value: CLM:0010001 MBA:596 {CLM:0010002="0.15", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF acronym region."} property_value: CLM:0010001 MBA:698 {CLM:0010002="0.11", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF broad region."} property_value: CLM:0010001 MBA:803 {CLM:0010002="0.42", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF broad region."} property_value: CLM:0010001 MBA:997 {CLM:0010002="0.14", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF broad region."} property_value: CLM:0010003 CLM:5004314 property_value: CLM:0010003 CLM:5007635 {STATO:0000663="0.9917355"} property_value: CLM:0010003 CLM:5007802 {STATO:0000663="0.9917355"} property_value: CLM:0010003 CLM:5019534 property_value: IAO:0000028 "HY Gnrh1 Glut (Mmus)" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#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%2BDggl%2FA4SgGoeExD3ZBDJOUVRJRTdUQU1QOFBRQUhPNFAABYGvpkqB6awOgaCBR4CS1egGAAcAAAUABgEBAkZTMDBEWFYwVDlSMVg5Rko0UUUAA34AAAAEAAAIVkZPRllQRlFHUktVRFFVWjNGRgAJTFZEQkpBVzhCSTVZU1MxUVVCRwAKAAsBVExPS1dDTDk1UlUwM0Q5UEVURwACNzNHVlREWERFR0UyN00yWEpNVAADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAACAwA%3D" xsd:string {name="Reference data on Allen Brain Cell Atlas"} property_value: seeAlso "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_15.h5ad" xsd:string {comment="Warning large data file!", name="h5ad data file for CS20230722_CLAS_15"} [Term] id: CL:4306426 name: pinealocyte (Mmus) def: "A pinealocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Cngb3 (Mmus), Ush2a (Mmus). It is glutamatergic (inferred from expression of Ddc, Slc17a6, Slc17a7). These cells are located in the brain , in or close to the regions: third ventricle . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:4606 Pineal Crx Glut_1." [https://doi.org/10.1038/s41586-023-06812-z, https://doi.org/10.1111/j.1600-079x.1996.tb00284.x, https://doi.org/10.3389/fendo.2019.00590] comment: Rationale for assigning this type to reference data: Consistent with this cell set being composed of Pinealocytes, a combination of Pinealocyte markers Gngt1 and Crx can identify the cells in this cluster with a confidence (F-beta score) of 0.91 in the context of glutamatergic cells (Pinealocytes release glutamate) from the hippocampal formation dissection (which includes the pineal gland). Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions. {xref="https://doi.org/10.1111/j.1600-079x.1996.tb00284.x", xref="https://doi.org/10.3389/fendo.2019.00590"} subset: mouse_subset synonym: "1030 Pineal Crx Glut_1" EXACT [] synonym: "25 Pineal Glut" EXACT [] synonym: "262 Pineal Crx Glut" EXACT [] synonym: "4606 Pineal Crx Glut_1" EXACT [] is_a: CL:0000652 {evidence="http://identifiers.org/ncbigene/13195", evidence="http://identifiers.org/ncbigene/140919", evidence="http://identifiers.org/ncbigene/72961"} ! pinealocyte relationship: RO:0002162 NCBITaxon:10090 ! in taxon Mus musculus relationship: RO:0002215 GO:0061535 {comment="Inferred to be glutamate secretion, neurotransmission based on expression of Ddc, Slc17a6, Slc17a7"} ! capable of glutamate secretion, neurotransmission property_value: CLM:0010001 MBA:129 {CLM:0010002="0.38", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF acronym region."} property_value: CLM:0010001 MBA:997 {CLM:0010002="1.0", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF broad region."} property_value: CLM:0010003 CLM:5006356 property_value: CLM:0010003 CLM:5007645 {STATO:0000663="0.9782609"} property_value: CLM:0010003 CLM:5007922 {STATO:0000663="0.9782609"} property_value: CLM:0010003 CLM:5021576 property_value: CLM:0010003 CLM:5029176 property_value: IAO:0000028 "pinealocyte (Mmus)" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIBMjUgUGluZWFsIEdsdXQAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIAAAFDQkdDMFUzMFZWOUpQUjYwVEpVAAIAAAQBAQKBrMaOgZYVIAOEak39hFgYTQAFAAYBAQJGUzAwRFhWMFQ5UjFYOUZKNFFFAAN%2BAAAABAAACEc0STRHRkpYSkI5QVRaM1BUWDEACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAW5vbmUAAm5vbmUAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAUs5Sk4yM1AyNEtRQ0dLOVU3NUEAAkhTWVpQWlcxNjY5VTgyMUJXWVAAAwQBRlMwMERYVjBUOVIxWDlGSjRRRQACATI1IFBpbmVhbCBHbHV0AAABUVk1UzhLTU81SExKVUYwUDAwSwACAAABMTVCSzQ3RENJT0YxU0xMVVc5UAACAAABQ0JHQzBVMzBWVjlKUFI2MFRKVQACAAAEAQAChFC%2FH4OCCX8DhKAah4TEPdkEMk5RVElFN1RBTVA4UFFBSE80UAAFga%2BmSoHprA6BoIFHgJLV6AYABwAABQAGAQECRlMwMERYVjBUOVIxWDlGSjRRRQADfgAAAAQAAAhWRk9GWVBGUUdSS1VEUVVaM0ZGAAlMVkRCSkFXOEJJNVlTUzFRVUJHAAoACwFUTE9LV0NMOTVSVTAzRDlQRVRHAAI3M0dWVERYREVHRTI3TTJYSk1UAAMBBAEAAiMwMDAwMDAAA8gBAAUBAQIjMDAwMDAwAAPIAQAAAAIDAA%3D%3D" xsd:string {name="Reference data on Allen Brain Cell Atlas"} property_value: seeAlso "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_25.h5ad" xsd:string {comment="Warning large data file!", name="h5ad data file for CS20230722_CLAS_25"} [Term] id: CL:4306992 name: DCO Il22 Gly-Gaba_2 cerebellar neuron (Mmus) def: "A cerebellar neuron of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Il22 (Mmus), Edaradd (Mmus). It is distinguished from other DCO Il22 Gly-Gaba cells by expression of Ppp1r17. It is GABAergic and glycinergic (inferred from expression of Slc32a1, Hdc, Slc6a5, Gad2, Gad1). These cells are located in the Medulla, Cerebellum, brain , in or close to the regions: Paraflocculus, arbor vitae, Dorsal cochlear nucleus . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5172 DCO Il22 Gly-Gaba_2." [https://doi.org/10.1038/s41586-023-06812-z] comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions. subset: mouse_subset synonym: "1142 DCO Il22 Gly-Gaba_2" EXACT [] synonym: "5172 DCO Il22 Gly-Gaba_2" EXACT [] is_a: CL:4300348 ! DCO Il22 Gly-Gaba cerebellar neuron (Mmus) property_value: CLM:0010001 MBA:1041 {CLM:0010002="0.2", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF acronym region."} property_value: CLM:0010001 MBA:354 {CLM:0010002="0.44", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF broad region."} property_value: CLM:0010001 MBA:512 {CLM:0010002="0.25", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF broad region."} property_value: CLM:0010001 MBA:728 {CLM:0010002="0.16", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF acronym region."} property_value: CLM:0010001 MBA:96 {CLM:0010002="0.44", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF acronym region."} property_value: CLM:0010001 MBA:997 {CLM:0010002="0.31", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF broad region."} property_value: CLM:0010003 CLM:5006922 {STATO:0000663="0.8910891"} property_value: CLM:0010003 CLM:5022142 {STATO:0000663="0.9292035"} property_value: IAO:0000028 "DCO Il22 Gly-Gaba_2 (Mmus)" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIAAAFDQkdDMFUzMFZWOUpQUjYwVEpVAAIBNTE3MiBEQ08gSWwyMiBHbHktR2FiYV8yAAAEAQECgazGjoGWFSADhGpN%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%2BAAAABAAACFZGT0ZZUEZRR1JLVURRVVozRkYACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAVRMT0tXQ0w5NVJVMDNEOVBFVEcAAjczR1ZURFhERUdFMjdNMlhKTVQAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAgMA" xsd:string {name="Reference data on Allen Brain Cell Atlas"} property_value: seeAlso "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_28.h5ad" xsd:string {comment="Warning large data file!", name="h5ad data file for CS20230722_CLAS_28"} [Term] id: CL:4307005 name: CB PLI GABA Ly6d Purkinje layer interneuron def: "A Purkinje layer interneuron of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Ly6d (Mmus), Kit (Mmus). It is distinguished from other CB PLI Gly-Gaba cells by expression of Ly6d. It is GABAergic (inferred from expression of Gad1, Gad2, Slc32a1). These cells are located in the Cerebellum, brain , in or close to the regions: arbor vitae, Interposed nucleus, Nodulus (X) . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5185 CB PLI Gly-Gaba_4." [https://doi.org/10.1038/s41586-023-06812-z] comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions. Warning: Despite its name, CB PLI Gly-Gaba_4 does not secrete the neurotransmitter Gly, as assessed by expression of multiple marker genes. subset: mouse_subset synonym: "1147 CB PLI Gly-Gaba_4" EXACT [] synonym: "5185 CB PLI Gly-Gaba_4" EXACT [] is_a: CL:4300349 ! Purkinje layer interneuron (Mmus) property_value: CLM:0010001 MBA:512 {CLM:0010002="0.76", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF broad region."} property_value: CLM:0010001 MBA:728 {CLM:0010002="0.14", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF acronym region."} property_value: CLM:0010001 MBA:91 {CLM:0010002="0.11", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF acronym region."} property_value: CLM:0010001 MBA:968 {CLM:0010002="0.17", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF acronym region."} property_value: CLM:0010001 MBA:997 {CLM:0010002="0.2", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF broad region."} property_value: CLM:0010003 CLM:5006935 {STATO:0000663="0.8"} property_value: CLM:0010003 CLM:5022155 {STATO:0000663="0.9459459"} property_value: IAO:0000028 "CB PLI Gly-Gaba_4 (Mmus)" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#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%2BDggl%2FA4SgGoeExD3ZBDJOUVRJRTdUQU1QOFBRQUhPNFAABYGvpkqB6awOgaCBR4CS1egGAAcAAAUABgEBAkNCR0MwVTMwVlY5SlBSNjBUSlUAA34AAAAEAAAIVkZPRllQRlFHUktVRFFVWjNGRgAJTFZEQkpBVzhCSTVZU1MxUVVCRwAKAAsBVExPS1dDTDk1UlUwM0Q5UEVURwACNzNHVlREWERFR0UyN00yWEpNVAADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAACAwA%3D" xsd:string {name="Reference data on Allen Brain Cell Atlas"} property_value: seeAlso "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_28.h5ad" xsd:string {comment="Warning large data file!", name="h5ad data file for CS20230722_CLAS_28"} [Term] id: CL:4307012 name: CBX MLI Cdh22 Gaba molecular layer interneuron (Mmus) def: "A molecular layer interneuron of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Cdh1 (Mmus), Acvr1c (Mmus), Adamts15 (Mmus), Pax2 (Mmus). It is distinguished from other CB GABA cells by expression of Cdh1, Acvr1c, Adamts15, Pax2. It is GABAergic (inferred from expression of Gad1, Gad2, Slc32a1). These cells are located in the Cerebellum, brain . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5192 CBX MLI Cdh22 Gaba_1." [https://doi.org/10.1038/s41586-023-06812-z] comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions. subset: mouse_subset synonym: "1151 CBX MLI Cdh22 Gaba_1" EXACT [] synonym: "312 CBX MLI Cdh22 Gaba" EXACT [] synonym: "5192 CBX MLI Cdh22 Gaba_1" EXACT [] is_a: CL:4042035 {evidence="http://identifiers.org/ncbigene/14415", evidence="http://identifiers.org/ncbigene/14417", evidence="http://identifiers.org/ncbigene/22348"} ! molecular layer interneuron is_a: CL:4300028 ! cerebellar GABAergic neuron (Mmus) property_value: CLM:0010001 MBA:512 {CLM:0010002="0.69", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF broad region."} property_value: CLM:0010001 MBA:997 {CLM:0010002="0.31", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF broad region."} property_value: CLM:0010003 CLM:5006942 {STATO:0000663="0.6132075"} property_value: CLM:0010003 CLM:5007972 {STATO:0000663="0.5508475"} property_value: CLM:0010003 CLM:5022162 property_value: IAO:0000028 "CBX MLI Cdh22 Gaba (Mmus)" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#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%2BDggl%2FA4SgGoeExD3ZBDJOUVRJRTdUQU1QOFBRQUhPNFAABYGvpkqB6awOgaCBR4CS1egGAAcAAAUABgEBAlFZNVM4S01PNUhMSlVGMFAwMEsAA34AAAAEAAAIVkZPRllQRlFHUktVRFFVWjNGRgAJTFZEQkpBVzhCSTVZU1MxUVVCRwAKAAsBVExPS1dDTDk1UlUwM0Q5UEVURwACNzNHVlREWERFR0UyN00yWEpNVAADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAACAwA%3D" xsd:string {name="Reference data on Allen Brain Cell Atlas"} property_value: seeAlso "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_28.h5ad" xsd:string {comment="Warning large data file!", name="h5ad data file for CS20230722_CLAS_28"} [Term] id: CL:4307026 name: Bergmann glial cell (Mmus) def: "A Bergmann glial cell of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Gpr37l1 (Mmus), Ctxn3 (Mmus). It is distinguished from other Astro-Epen cells by expression of Gpr37l1, Ctxn3. These cells are located in the Cerebellum, brain . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5206 Bergmann NN_1." [https://doi.org/10.1038/s41586-023-06812-z] comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions. subset: human_subset subset: mouse_subset synonym: "1157 Bergmann NN_1" EXACT [] synonym: "316 Bergmann NN" EXACT [] synonym: "5206 Bergmann NN_1" EXACT [] is_a: CL:0000644 {evidence="http://identifiers.org/ncbigene/11668"} ! Bergmann glial cell property_value: CLM:0010001 MBA:512 {CLM:0010002="0.73", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF broad region."} property_value: CLM:0010001 MBA:997 {CLM:0010002="0.27", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF broad region."} property_value: CLM:0010003 CLM:5006956 {STATO:0000663="0.8908046"} property_value: CLM:0010003 CLM:5007976 {STATO:0000663="0.8908046"} property_value: CLM:0010003 CLM:5022176 property_value: IAO:0000028 "Bergmann glial cell (Mmus)" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIBMzE2IEJlcmdtYW5uIE5OAAABMTVCSzQ3RENJT0YxU0xMVVc5UAACAAABQ0JHQzBVMzBWVjlKUFI2MFRKVQACAAAEAQECgazGjoGWFSADhGpN%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%2BAAAABAAACFZGT0ZZUEZRR1JLVURRVVozRkYACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAVRMT0tXQ0w5NVJVMDNEOVBFVEcAAjczR1ZURFhERUdFMjdNMlhKTVQAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAgMA" xsd:string {name="Reference data on Allen Brain Cell Atlas"} property_value: seeAlso "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_30.h5ad" xsd:string {comment="Warning large data file!", name="h5ad data file for CS20230722_CLAS_30"} [Term] id: CL:4307027 name: cerebellar astrocyte (Mmus) def: "A transcriptomically defined type of astrocyte localized exclusively in the cerebellum beneath the Purkinje cell layer. It is distinguished from other cells in the brain by selective expression of Dao (Mmus), Efemp1 (Mmus). Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5207 Astro-CB NN_1." [https://doi.org/10.1038/s41586-023-06812-z] comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions. subset: human_subset subset: mouse_subset synonym: "1158 Astro-CB NN_1" EXACT [] synonym: "317 Astro-CB NN" EXACT [] synonym: "5207 Astro-CB NN_1" EXACT [] is_a: CL:0002603 {evidence="http://identifiers.org/ncbigene/11668"} ! astrocyte of the cerebellum property_value: CLM:0010001 MBA:512 {CLM:0010002="0.65", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF broad region."} property_value: CLM:0010001 MBA:728 {CLM:0010002="0.14", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF acronym region."} property_value: CLM:0010001 MBA:997 {CLM:0010002="0.34", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF broad region."} property_value: CLM:0010003 CLM:5006957 {STATO:0000663="0.6321839"} property_value: CLM:0010003 CLM:5007977 {STATO:0000663="0.6849315"} property_value: CLM:0010003 CLM:5022177 property_value: IAO:0000028 "cerebellar astrocyte (Mmus)" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIBMzE3IEFzdHJvLUNCIE5OAAABMTVCSzQ3RENJT0YxU0xMVVc5UAACAAABQ0JHQzBVMzBWVjlKUFI2MFRKVQACAAAEAQECgazGjoGWFSADhGpN%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%2BAAAABAAACFZGT0ZZUEZRR1JLVURRVVozRkYACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAVRMT0tXQ0w5NVJVMDNEOVBFVEcAAjczR1ZURFhERUdFMjdNMlhKTVQAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAgMA" xsd:string {name="Reference data on Allen Brain Cell Atlas"} property_value: seeAlso "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_30.h5ad" xsd:string {comment="Warning large data file!", name="h5ad data file for CS20230722_CLAS_30"} [Term] id: CL:4307028 name: Astro-NT NN_1 Galnt15 astrocyte (Mmus) def: "A astrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Gfap (Mmus), Galnt15 (Mmus), Agt (Mmus). It is distinguished from other Astro-NT NN_1 cells by expression of Galnt15. These cells are located in the Cerebellum, brain , in or close to the regions: arbor vitae . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5208 Astro-NT NN_1." [https://doi.org/10.1038/s41586-023-06812-z] comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions. subset: human_subset subset: mouse_subset synonym: "5208 Astro-NT NN_1" EXACT [] is_a: CL:4301589 ! Astro-NT NN_1 astrocyte (Mmus) property_value: CLM:0010001 MBA:512 {CLM:0010002="0.32", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF broad region."} property_value: CLM:0010001 MBA:728 {CLM:0010002="0.15", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF acronym region."} property_value: CLM:0010001 MBA:997 {CLM:0010002="0.57", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF broad region."} property_value: CLM:0010003 CLM:5006958 {STATO:0000663="0.3030303"} property_value: CLM:0010003 CLM:5022178 {STATO:0000663="0.74"} property_value: IAO:0000028 "Astro-NT NN_1 Galnt15 (Mmus)" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIAAAFDQkdDMFUzMFZWOUpQUjYwVEpVAAIBNTIwOCBBc3Ryby1OVCBOTl8xAAAEAQECgazGjoGWFSADhGpN%2FYRYGE0ABQAGAQECQ0JHQzBVMzBWVjlKUFI2MFRKVQADfgAAAAQAAAhHNEk0R0ZKWEpCOUFUWjNQVFgxAAlMVkRCSkFXOEJJNVlTUzFRVUJHAAoACwFub25lAAJub25lAAMBBAEAAiMwMDAwMDAAA8gBAAUBAQIjMDAwMDAwAAPIAQAAAAFLOUpOMjNQMjRLUUNHSzlVNzVBAAJIU1laUFpXMTY2OVU4MjFCV1lQAAMEAUZTMDBEWFYwVDlSMVg5Rko0UUUAAgAAAVFZNVM4S01PNUhMSlVGMFAwMEsAAgAAATE1Qks0N0RDSU9GMVNMTFVXOVAAAgAAAUNCR0MwVTMwVlY5SlBSNjBUSlUAAgE1MjA4IEFzdHJvLU5UIE5OXzEAAAQBAAKEUL8fg4IJfwOEoBqHhMQ92QQyTlFUSUU3VEFNUDhQUUFITzRQAAWBr6ZKgemsDoGggUeAktXoBgAHAAAFAAYBAQJDQkdDMFUzMFZWOUpQUjYwVEpVAAN%2BAAAABAAACFZGT0ZZUEZRR1JLVURRVVozRkYACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAVRMT0tXQ0w5NVJVMDNEOVBFVEcAAjczR1ZURFhERUdFMjdNMlhKTVQAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAgMA" xsd:string {name="Reference data on Allen Brain Cell Atlas"} property_value: seeAlso "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_30.h5ad" xsd:string {comment="Warning large data file!", name="h5ad data file for CS20230722_CLAS_30"} [Term] id: CL:4307029 name: Astro-NT NN_1 Slc36a2 astrocyte (Mmus) def: "A astrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Gfap (Mmus), Slc36a2 (Mmus), Sfrp5 (Mmus). It is distinguished from other Astro-NT NN_1 cells by expression of Slc36a2, Sfrp5. These cells are located in the Midbrain, Cerebellum, brain . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5209 Astro-NT NN_1." [https://doi.org/10.1038/s41586-023-06812-z] comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions. subset: human_subset subset: mouse_subset synonym: "5209 Astro-NT NN_1" EXACT [] is_a: CL:4301589 ! Astro-NT NN_1 astrocyte (Mmus) property_value: CLM:0010001 MBA:313 {CLM:0010002="0.12", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF broad region."} property_value: CLM:0010001 MBA:512 {CLM:0010002="0.1", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF broad region."} property_value: CLM:0010001 MBA:997 {CLM:0010002="0.56", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF broad region."} property_value: CLM:0010003 CLM:5006959 {STATO:0000663="0.35714287"} property_value: CLM:0010003 CLM:5022179 {STATO:0000663="0.4878049"} property_value: IAO:0000028 "Astro-NT NN_1 Slc36a2 (Mmus)" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIAAAFDQkdDMFUzMFZWOUpQUjYwVEpVAAIBNTIwOSBBc3Ryby1OVCBOTl8xAAAEAQECgazGjoGWFSADhGpN%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%2BAAAABAAACFZGT0ZZUEZRR1JLVURRVVozRkYACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAVRMT0tXQ0w5NVJVMDNEOVBFVEcAAjczR1ZURFhERUdFMjdNMlhKTVQAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAgMA" xsd:string {name="Reference data on Allen Brain Cell Atlas"} property_value: seeAlso "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_30.h5ad" xsd:string {comment="Warning large data file!", name="h5ad data file for CS20230722_CLAS_30"} [Term] id: CL:4307030 name: Astro-NT NN_1 Nuf2 astrocyte (Mmus) def: "A astrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Gfap (Mmus), Sfrp5 (Mmus), Cldn10 (Mmus), Riiad1 (Mmus). It is distinguished from other Astro-NT NN_1 cells by expression of Nuf2, Shroom3. These cells are located in the Cerebellum, brain , in or close to the regions: arbor vitae . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5210 Astro-NT NN_1." [https://doi.org/10.1038/s41586-023-06812-z] comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions. subset: human_subset subset: mouse_subset synonym: "5210 Astro-NT NN_1" EXACT [] is_a: CL:4301589 ! Astro-NT NN_1 astrocyte (Mmus) property_value: CLM:0010001 MBA:512 {CLM:0010002="0.26", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF broad region."} property_value: CLM:0010001 MBA:728 {CLM:0010002="0.16", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF acronym region."} property_value: CLM:0010001 MBA:997 {CLM:0010002="0.51", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF broad region."} property_value: CLM:0010003 CLM:5006960 {STATO:0000663="0.27027026"} property_value: CLM:0010003 CLM:5022180 {STATO:0000663="0.4918033"} property_value: IAO:0000028 "Astro-NT NN_1 Nuf2 (Mmus)" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIAAAFDQkdDMFUzMFZWOUpQUjYwVEpVAAIBNTIxMCBBc3Ryby1OVCBOTl8xAAAEAQECgazGjoGWFSADhGpN%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%2BAAAABAAACFZGT0ZZUEZRR1JLVURRVVozRkYACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAVRMT0tXQ0w5NVJVMDNEOVBFVEcAAjczR1ZURFhERUdFMjdNMlhKTVQAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAgMA" xsd:string {name="Reference data on Allen Brain Cell Atlas"} property_value: seeAlso "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_30.h5ad" xsd:string {comment="Warning large data file!", name="h5ad data file for CS20230722_CLAS_30"} [Term] id: CL:4307031 name: Astro-NT NN_1 Six3os1 astrocyte (Mmus) def: "A astrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Myoc (Mmus), Six3os1 (Mmus), Slc36a2 (Mmus). It is distinguished from other Astro-NT NN_1 cells by expression of Six3os1. These cells are located in the Striatum-like amygdalar nuclei, Olfactory areas, brain , in or close to the regions: Medial amygdalar nucleus . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5211 Astro-NT NN_1." [https://doi.org/10.1038/s41586-023-06812-z] comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions. subset: human_subset subset: mouse_subset synonym: "5211 Astro-NT NN_1" EXACT [] is_a: CL:4301589 ! Astro-NT NN_1 astrocyte (Mmus) property_value: CLM:0010001 MBA:278 {CLM:0010002="0.12", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF broad region."} property_value: CLM:0010001 MBA:403 {CLM:0010002="0.1", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF acronym region."} property_value: CLM:0010001 MBA:698 {CLM:0010002="0.14", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF broad region."} property_value: CLM:0010001 MBA:997 {CLM:0010002="0.48", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF broad region."} property_value: CLM:0010003 CLM:5006961 {STATO:0000663="0.3030303"} property_value: CLM:0010003 CLM:5022181 {STATO:0000663="0.6097561"} property_value: IAO:0000028 "Astro-NT NN_1 Six3os1 (Mmus)" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIAAAFDQkdDMFUzMFZWOUpQUjYwVEpVAAIBNTIxMSBBc3Ryby1OVCBOTl8xAAAEAQECgazGjoGWFSADhGpN%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%2BAAAABAAACFZGT0ZZUEZRR1JLVURRVVozRkYACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAVRMT0tXQ0w5NVJVMDNEOVBFVEcAAjczR1ZURFhERUdFMjdNMlhKTVQAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAgMA" xsd:string {name="Reference data on Allen Brain Cell Atlas"} property_value: seeAlso "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_30.h5ad" xsd:string {comment="Warning large data file!", name="h5ad data file for CS20230722_CLAS_30"} [Term] id: CL:4307032 name: Astro-NT NN_1 Kcnk10 astrocyte (Mmus) def: "A astrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Agt (Mmus), Prss35 (Mmus), C4b (Mmus). It is distinguished from other Astro-NT NN_1 cells by expression of Kcnk10, C4b. These cells are located in the Medulla, Cerebellum, brain , in or close to the regions: arbor vitae . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5212 Astro-NT NN_1." [https://doi.org/10.1038/s41586-023-06812-z] comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions. subset: human_subset subset: mouse_subset synonym: "5212 Astro-NT NN_1" EXACT [] is_a: CL:4301589 ! Astro-NT NN_1 astrocyte (Mmus) property_value: CLM:0010001 MBA:354 {CLM:0010002="0.1", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF broad region."} property_value: CLM:0010001 MBA:512 {CLM:0010002="0.21", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF broad region."} property_value: CLM:0010001 MBA:728 {CLM:0010002="0.2", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF acronym region."} property_value: CLM:0010001 MBA:997 {CLM:0010002="0.58", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF broad region."} property_value: CLM:0010003 CLM:5006962 {STATO:0000663="0.16129032"} property_value: CLM:0010003 CLM:5022182 {STATO:0000663="0.16129032"} property_value: IAO:0000028 "Astro-NT NN_1 Kcnk10 (Mmus)" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIAAAFDQkdDMFUzMFZWOUpQUjYwVEpVAAIBNTIxMiBBc3Ryby1OVCBOTl8xAAAEAQECgazGjoGWFSADhGpN%2FYRYGE0ABQAGAQECQ0JHQzBVMzBWVjlKUFI2MFRKVQADfgAAAAQAAAhHNEk0R0ZKWEpCOUFUWjNQVFgxAAlMVkRCSkFXOEJJNVlTUzFRVUJHAAoACwFub25lAAJub25lAAMBBAEAAiMwMDAwMDAAA8gBAAUBAQIjMDAwMDAwAAPIAQAAAAFLOUpOMjNQMjRLUUNHSzlVNzVBAAJIU1laUFpXMTY2OVU4MjFCV1lQAAMEAUZTMDBEWFYwVDlSMVg5Rko0UUUAAgAAAVFZNVM4S01PNUhMSlVGMFAwMEsAAgAAATE1Qks0N0RDSU9GMVNMTFVXOVAAAgAAAUNCR0MwVTMwVlY5SlBSNjBUSlUAAgE1MjEyIEFzdHJvLU5UIE5OXzEAAAQBAAKEUL8fg4IJfwOEoBqHhMQ92QQyTlFUSUU3VEFNUDhQUUFITzRQAAWBr6ZKgemsDoGggUeAktXoBgAHAAAFAAYBAQJDQkdDMFUzMFZWOUpQUjYwVEpVAAN%2BAAAABAAACFZGT0ZZUEZRR1JLVURRVVozRkYACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAVRMT0tXQ0w5NVJVMDNEOVBFVEcAAjczR1ZURFhERUdFMjdNMlhKTVQAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAgMA" xsd:string {name="Reference data on Allen Brain Cell Atlas"} property_value: seeAlso "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_30.h5ad" xsd:string {comment="Warning large data file!", name="h5ad data file for CS20230722_CLAS_30"} [Term] id: CL:4307033 name: Astro-NT NN_1 Mecom astrocyte (Mmus) def: "A astrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Dao (Mmus), Mecom (Mmus), Fbln5 (Mmus), Prelp (Mmus). It is distinguished from other Astro-NT NN_1 cells by expression of Mecom, Prelp. These cells are located in the Medulla, Cerebellum, brain , in or close to the regions: Ventral cochlear nucleus, Paraflocculus, Flocculus, Dorsal cochlear nucleus . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5213 Astro-NT NN_1." [https://doi.org/10.1038/s41586-023-06812-z] comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions. subset: human_subset subset: mouse_subset synonym: "5213 Astro-NT NN_1" EXACT [] is_a: CL:4301589 ! Astro-NT NN_1 astrocyte (Mmus) property_value: CLM:0010001 MBA:101 {CLM:0010002="0.35", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF acronym region."} property_value: CLM:0010001 MBA:1041 {CLM:0010002="0.1", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF acronym region."} property_value: CLM:0010001 MBA:1049 {CLM:0010002="0.18", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF acronym region."} property_value: CLM:0010001 MBA:354 {CLM:0010002="0.5", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF broad region."} property_value: CLM:0010001 MBA:512 {CLM:0010002="0.3", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF broad region."} property_value: CLM:0010001 MBA:96 {CLM:0010002="0.14", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF acronym region."} property_value: CLM:0010001 MBA:997 {CLM:0010002="0.2", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF broad region."} property_value: CLM:0010003 CLM:5006963 {STATO:0000663="0.5882353"} property_value: CLM:0010003 CLM:5022183 {STATO:0000663="0.5"} property_value: IAO:0000028 "Astro-NT NN_1 Mecom (Mmus)" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIAAAFDQkdDMFUzMFZWOUpQUjYwVEpVAAIBNTIxMyBBc3Ryby1OVCBOTl8xAAAEAQECgazGjoGWFSADhGpN%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%2BAAAABAAACFZGT0ZZUEZRR1JLVURRVVozRkYACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAVRMT0tXQ0w5NVJVMDNEOVBFVEcAAjczR1ZURFhERUdFMjdNMlhKTVQAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAgMA" xsd:string {name="Reference data on Allen Brain Cell Atlas"} property_value: seeAlso "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_30.h5ad" xsd:string {comment="Warning large data file!", name="h5ad data file for CS20230722_CLAS_30"} [Term] id: CL:4307034 name: Astro-NT NN_2 Fzd2 astrocyte (Mmus) def: "A astrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Gja1 (Mmus), A330076C08Rik (Mmus), Sfrp5 (Mmus), Gria2 (Mmus). It is distinguished from other Astro-NT NN_2 cells by expression of Fzd2, Gria2, Ttll3. These cells are located in the Midbrain, Thalamus, Pons , in or close to the regions: Midbrain reticular nucleus . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5214 Astro-NT NN_2." [https://doi.org/10.1038/s41586-023-06812-z] comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions. subset: human_subset subset: mouse_subset synonym: "5214 Astro-NT NN_2" EXACT [] is_a: CL:4301590 ! Astro-NT NN_2 astrocyte (Mmus) property_value: CLM:0010001 MBA:128 {CLM:0010002="0.1", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF acronym region."} property_value: CLM:0010001 MBA:313 {CLM:0010002="0.56", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF broad region."} property_value: CLM:0010001 MBA:549 {CLM:0010002="0.11", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF broad region."} property_value: CLM:0010001 MBA:771 {CLM:0010002="0.1", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF broad region."} property_value: CLM:0010003 CLM:5006964 {STATO:0000663="0.2631579"} property_value: CLM:0010003 CLM:5022184 {STATO:0000663="0.3030303"} property_value: IAO:0000028 "Astro-NT NN_2 Fzd2 (Mmus)" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIAAAFDQkdDMFUzMFZWOUpQUjYwVEpVAAIBNTIxNCBBc3Ryby1OVCBOTl8yAAAEAQECgazGjoGWFSADhGpN%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%2BAAAABAAACFZGT0ZZUEZRR1JLVURRVVozRkYACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAVRMT0tXQ0w5NVJVMDNEOVBFVEcAAjczR1ZURFhERUdFMjdNMlhKTVQAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAgMA" xsd:string {name="Reference data on Allen Brain Cell Atlas"} property_value: seeAlso "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_30.h5ad" xsd:string {comment="Warning large data file!", name="h5ad data file for CS20230722_CLAS_30"} [Term] id: CL:4307035 name: Astro-NT NN_2 Sez6l astrocyte (Mmus) def: "A astrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Gja1 (Mmus), A330076C08Rik (Mmus), Otx2 (Mmus), Unc13c (Mmus). It is distinguished from other Astro-NT NN_2 cells by expression of Sez6l, Unc13c. These cells are located in the Thalamus , in or close to the regions: Posterior complex of the thalamus, Ventral posteromedial nucleus of the thalamus . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5215 Astro-NT NN_2." [https://doi.org/10.1038/s41586-023-06812-z] comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions. subset: human_subset subset: mouse_subset synonym: "5215 Astro-NT NN_2" EXACT [] is_a: CL:4301590 ! Astro-NT NN_2 astrocyte (Mmus) property_value: CLM:0010001 MBA:1020 {CLM:0010002="0.14", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF acronym region."} property_value: CLM:0010001 MBA:549 {CLM:0010002="0.91", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF broad region."} property_value: CLM:0010001 MBA:733 {CLM:0010002="0.17", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF acronym region."} property_value: CLM:0010003 CLM:5006965 {STATO:0000663="0.24193548"} property_value: CLM:0010003 CLM:5022185 {STATO:0000663="0.44871795"} property_value: IAO:0000028 "Astro-NT NN_2 Sez6l (Mmus)" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIAAAFDQkdDMFUzMFZWOUpQUjYwVEpVAAIBNTIxNSBBc3Ryby1OVCBOTl8yAAAEAQECgazGjoGWFSADhGpN%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%2BAAAABAAACFZGT0ZZUEZRR1JLVURRVVozRkYACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAVRMT0tXQ0w5NVJVMDNEOVBFVEcAAjczR1ZURFhERUdFMjdNMlhKTVQAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAgMA" xsd:string {name="Reference data on Allen Brain Cell Atlas"} property_value: seeAlso "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_30.h5ad" xsd:string {comment="Warning large data file!", name="h5ad data file for CS20230722_CLAS_30"} [Term] id: CL:4307036 name: Astro-NT NN_2 Fam227b astrocyte (Mmus) def: "A astrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Slc7a10 (Mmus), Cyp26b1 (Mmus), Igfbp2 (Mmus), Shroom3 (Mmus). It is distinguished from other Astro-NT NN_2 cells by expression of Fam227b, Shroom3. These cells are located in the Midbrain, Medulla, Pons . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5216 Astro-NT NN_2." [https://doi.org/10.1038/s41586-023-06812-z] comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions. subset: human_subset subset: mouse_subset synonym: "5216 Astro-NT NN_2" EXACT [] is_a: CL:4301590 ! Astro-NT NN_2 astrocyte (Mmus) property_value: CLM:0010001 MBA:313 {CLM:0010002="0.19", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF broad region."} property_value: CLM:0010001 MBA:354 {CLM:0010002="0.35", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF broad region."} property_value: CLM:0010001 MBA:771 {CLM:0010002="0.27", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF broad region."} property_value: CLM:0010003 CLM:5006966 {STATO:0000663="0.1724138"} property_value: CLM:0010003 CLM:5022186 {STATO:0000663="0.2857143"} property_value: IAO:0000028 "Astro-NT NN_2 Fam227b (Mmus)" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIAAAFDQkdDMFUzMFZWOUpQUjYwVEpVAAIBNTIxNiBBc3Ryby1OVCBOTl8yAAAEAQECgazGjoGWFSADhGpN%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%2BAAAABAAACFZGT0ZZUEZRR1JLVURRVVozRkYACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAVRMT0tXQ0w5NVJVMDNEOVBFVEcAAjczR1ZURFhERUdFMjdNMlhKTVQAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAgMA" xsd:string {name="Reference data on Allen Brain Cell Atlas"} property_value: seeAlso "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_30.h5ad" xsd:string {comment="Warning large data file!", name="h5ad data file for CS20230722_CLAS_30"} [Term] id: CL:4307037 name: Astro-NT NN_2 Gm30524 astrocyte (Mmus) def: "A astrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Aqp4 (Mmus), A330076C08Rik (Mmus), Fbln5 (Mmus), Mdga2 (Mmus). It is distinguished from other Astro-NT NN_2 cells by expression of Gm30524. These cells are located in the Medulla, Cerebellum, brain , in or close to the regions: Ventral cochlear nucleus, arbor vitae . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5217 Astro-NT NN_2." [https://doi.org/10.1038/s41586-023-06812-z] comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions. subset: human_subset subset: mouse_subset synonym: "5217 Astro-NT NN_2" EXACT [] is_a: CL:4301590 ! Astro-NT NN_2 astrocyte (Mmus) property_value: CLM:0010001 MBA:101 {CLM:0010002="0.1", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF acronym region."} property_value: CLM:0010001 MBA:354 {CLM:0010002="0.33", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF broad region."} property_value: CLM:0010001 MBA:512 {CLM:0010002="0.26", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF broad region."} property_value: CLM:0010001 MBA:728 {CLM:0010002="0.11", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF acronym region."} property_value: CLM:0010001 MBA:997 {CLM:0010002="0.22", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF broad region."} property_value: CLM:0010003 CLM:5006967 {STATO:0000663="0.09259259"} property_value: CLM:0010003 CLM:5022187 {STATO:0000663="0.5555556"} property_value: IAO:0000028 "Astro-NT NN_2 Gm30524 (Mmus)" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIAAAFDQkdDMFUzMFZWOUpQUjYwVEpVAAIBNTIxNyBBc3Ryby1OVCBOTl8yAAAEAQECgazGjoGWFSADhGpN%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%2BAAAABAAACFZGT0ZZUEZRR1JLVURRVVozRkYACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAVRMT0tXQ0w5NVJVMDNEOVBFVEcAAjczR1ZURFhERUdFMjdNMlhKTVQAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAgMA" xsd:string {name="Reference data on Allen Brain Cell Atlas"} property_value: seeAlso "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_30.h5ad" xsd:string {comment="Warning large data file!", name="h5ad data file for CS20230722_CLAS_30"} [Term] id: CL:4307038 name: Astro-TE NN_1 Myoc astrocyte (Mmus) def: "A astrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Myoc (Mmus), Lhx2 (Mmus), Kcne1l (Mmus), Alpk1 (Mmus). It is distinguished from other Astro-TE NN_1 cells by expression of Myoc, Kcne1l, Alpk1. These cells are located in the Isocortex, Olfactory areas, brain . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5218 Astro-TE NN_1." [https://doi.org/10.1038/s41586-023-06812-z] comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions. subset: human_subset subset: mouse_subset synonym: "5218 Astro-TE NN_1" EXACT [] is_a: CL:4301591 ! Astro-TE NN_1 astrocyte (Mmus) property_value: CLM:0010001 MBA:315 {CLM:0010002="0.23", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF broad region."} property_value: CLM:0010001 MBA:698 {CLM:0010002="0.15", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF broad region."} property_value: CLM:0010001 MBA:997 {CLM:0010002="0.55", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF broad region."} property_value: CLM:0010003 CLM:5006968 {STATO:0000663="0.1724138"} property_value: CLM:0010003 CLM:5022188 {STATO:0000663="0.3030303"} property_value: IAO:0000028 "Astro-TE NN_1 Myoc (Mmus)" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIAAAFDQkdDMFUzMFZWOUpQUjYwVEpVAAIBNTIxOCBBc3Ryby1URSBOTl8xAAAEAQECgazGjoGWFSADhGpN%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%2BAAAABAAACFZGT0ZZUEZRR1JLVURRVVozRkYACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAVRMT0tXQ0w5NVJVMDNEOVBFVEcAAjczR1ZURFhERUdFMjdNMlhKTVQAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAgMA" xsd:string {name="Reference data on Allen Brain Cell Atlas"} property_value: seeAlso "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_30.h5ad" xsd:string {comment="Warning large data file!", name="h5ad data file for CS20230722_CLAS_30"} [Term] id: CL:4307039 name: Astro-TE NN_1 Rasl10b astrocyte (Mmus) def: "A astrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Gfap (Mmus), Ddn (Mmus), Myoc (Mmus), Rasl10b (Mmus). It is distinguished from other Astro-TE NN_1 cells by expression of Rasl10b, Igfbp5. These cells are located in the Hippocampal region, Isocortex, brain . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5219 Astro-TE NN_1." [https://doi.org/10.1038/s41586-023-06812-z] comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions. subset: human_subset subset: mouse_subset synonym: "5219 Astro-TE NN_1" EXACT [] is_a: CL:4301591 ! Astro-TE NN_1 astrocyte (Mmus) property_value: CLM:0010001 MBA:1080 {CLM:0010002="0.15", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF broad region."} property_value: CLM:0010001 MBA:315 {CLM:0010002="0.2", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF broad region."} property_value: CLM:0010001 MBA:997 {CLM:0010002="0.42", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF broad region."} property_value: CLM:0010003 CLM:5006969 {STATO:0000663="0.09259259"} property_value: CLM:0010003 CLM:5022189 {STATO:0000663="0.48319328"} property_value: IAO:0000028 "Astro-TE NN_1 Rasl10b (Mmus)" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIAAAFDQkdDMFUzMFZWOUpQUjYwVEpVAAIBNTIxOSBBc3Ryby1URSBOTl8xAAAEAQECgazGjoGWFSADhGpN%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%2BAAAABAAACFZGT0ZZUEZRR1JLVURRVVozRkYACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAVRMT0tXQ0w5NVJVMDNEOVBFVEcAAjczR1ZURFhERUdFMjdNMlhKTVQAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAgMA" xsd:string {name="Reference data on Allen Brain Cell Atlas"} property_value: seeAlso "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_30.h5ad" xsd:string {comment="Warning large data file!", name="h5ad data file for CS20230722_CLAS_30"} [Term] id: CL:4307040 name: Astro-TE NN_1 Lncpint astrocyte (Mmus) def: "A astrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Myoc (Mmus), Dio2 (Mmus), Lncpint (Mmus). It is distinguished from other Astro-TE NN_1 cells by expression of Myoc, Lncpint. These cells are located in the brain . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5220 Astro-TE NN_1." [https://doi.org/10.1038/s41586-023-06812-z] comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions. subset: human_subset subset: mouse_subset synonym: "5220 Astro-TE NN_1" EXACT [] is_a: CL:4301591 ! Astro-TE NN_1 astrocyte (Mmus) property_value: CLM:0010001 MBA:997 {CLM:0010002="0.67", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF broad region."} property_value: CLM:0010003 CLM:5006970 {STATO:0000663="0.20588236"} property_value: CLM:0010003 CLM:5022190 {STATO:0000663="0.1724138"} property_value: IAO:0000028 "Astro-TE NN_1 Lncpint (Mmus)" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIAAAFDQkdDMFUzMFZWOUpQUjYwVEpVAAIBNTIyMCBBc3Ryby1URSBOTl8xAAAEAQECgazGjoGWFSADhGpN%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%2BAAAABAAACFZGT0ZZUEZRR1JLVURRVVozRkYACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAVRMT0tXQ0w5NVJVMDNEOVBFVEcAAjczR1ZURFhERUdFMjdNMlhKTVQAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAgMA" xsd:string {name="Reference data on Allen Brain Cell Atlas"} property_value: seeAlso "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_30.h5ad" xsd:string {comment="Warning large data file!", name="h5ad data file for CS20230722_CLAS_30"} [Term] id: CL:4307041 name: Astro-TE NN_1 Jph4 astrocyte (Mmus) def: "A astrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Myoc (Mmus), Sptbn2 (Mmus), Alpk1 (Mmus). It is distinguished from other Astro-TE NN_1 cells by expression of Myoc, Jph4, Alpk1. It is glutamatergic (inferred from expression of Aldh1a1, Slc17a7). These cells are located in the Isocortex, brain . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5221 Astro-TE NN_1." [https://doi.org/10.1038/s41586-023-06812-z] comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions. subset: human_subset subset: mouse_subset synonym: "5221 Astro-TE NN_1" EXACT [] is_a: CL:0000151 ! secretory cell is_a: CL:4301591 ! Astro-TE NN_1 astrocyte (Mmus) relationship: RO:0002215 GO:0061535 {comment="Inferred to be glutamate secretion, neurotransmission based on expression of Aldh1a1, Slc17a7"} ! capable of glutamate secretion, neurotransmission property_value: CLM:0010001 MBA:315 {CLM:0010002="0.19", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF broad region."} property_value: CLM:0010001 MBA:997 {CLM:0010002="0.76", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF broad region."} property_value: CLM:0010003 CLM:5006971 {STATO:0000663="0.26595744"} property_value: CLM:0010003 CLM:5022191 {STATO:0000663="0.5797101"} property_value: IAO:0000028 "Astro-TE NN_1 Jph4 (Mmus)" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIAAAFDQkdDMFUzMFZWOUpQUjYwVEpVAAIBNTIyMSBBc3Ryby1URSBOTl8xAAAEAQECgazGjoGWFSADhGpN%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%2BAAAABAAACFZGT0ZZUEZRR1JLVURRVVozRkYACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAVRMT0tXQ0w5NVJVMDNEOVBFVEcAAjczR1ZURFhERUdFMjdNMlhKTVQAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAgMA" xsd:string {name="Reference data on Allen Brain Cell Atlas"} property_value: seeAlso "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_30.h5ad" xsd:string {comment="Warning large data file!", name="h5ad data file for CS20230722_CLAS_30"} [Term] id: CL:4307042 name: Astro-TE NN_2 Clstn2 astrocyte (Mmus) def: "A astrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Gm6145 (Mmus), E330013P04Rik (Mmus), Slc39a12 (Mmus). It is distinguished from other Astro-TE NN_2 cells by expression of Clstn2. These cells are located in the Hippocampal region , in or close to the regions: Dentate gyrus, molecular layer, Dentate gyrus, polymorph layer, Field CA3, stratum oriens, Dentate gyrus, granule cell layer . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5222 Astro-TE NN_2." [https://doi.org/10.1038/s41586-023-06812-z] comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions. subset: human_subset subset: mouse_subset synonym: "5222 Astro-TE NN_2" EXACT [] is_a: CL:4301592 ! Astro-TE NN_2 astrocyte (Mmus) property_value: CLM:0010001 MBA:10703 {CLM:0010002="0.19", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF acronym region."} property_value: CLM:0010001 MBA:10704 {CLM:0010002="0.19", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF acronym region."} property_value: CLM:0010001 MBA:1080 {CLM:0010002="0.97", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF broad region."} property_value: CLM:0010001 MBA:486 {CLM:0010002="0.1", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF acronym region."} property_value: CLM:0010001 MBA:632 {CLM:0010002="0.27", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF acronym region."} property_value: CLM:0010003 CLM:5006972 {STATO:0000663="0.39215687"} property_value: CLM:0010003 CLM:5022192 {STATO:0000663="0.7758621"} property_value: IAO:0000028 "Astro-TE NN_2 Clstn2 (Mmus)" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIAAAFDQkdDMFUzMFZWOUpQUjYwVEpVAAIBNTIyMiBBc3Ryby1URSBOTl8yAAAEAQECgazGjoGWFSADhGpN%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%2BAAAABAAACFZGT0ZZUEZRR1JLVURRVVozRkYACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAVRMT0tXQ0w5NVJVMDNEOVBFVEcAAjczR1ZURFhERUdFMjdNMlhKTVQAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAgMA" xsd:string {name="Reference data on Allen Brain Cell Atlas"} property_value: seeAlso "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_30.h5ad" xsd:string {comment="Warning large data file!", name="h5ad data file for CS20230722_CLAS_30"} [Term] id: CL:4307043 name: Astro-TE NN_2 Mcm6 astrocyte (Mmus) def: "A astrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Mcm6 (Mmus), Egfr (Mmus), Pcsk6 (Mmus). It is distinguished from other Astro-TE NN_2 cells by expression of Mcm6. These cells are located in the Hippocampal region , in or close to the regions: Dentate gyrus, molecular layer, Dentate gyrus, polymorph layer, Dentate gyrus, granule cell layer . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5223 Astro-TE NN_2." [https://doi.org/10.1038/s41586-023-06812-z] comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions. subset: human_subset subset: mouse_subset synonym: "5223 Astro-TE NN_2" EXACT [] is_a: CL:4301592 ! Astro-TE NN_2 astrocyte (Mmus) property_value: CLM:0010001 MBA:10703 {CLM:0010002="0.26", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF acronym region."} property_value: CLM:0010001 MBA:10704 {CLM:0010002="0.14", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF acronym region."} property_value: CLM:0010001 MBA:1080 {CLM:0010002="0.9", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF broad region."} property_value: CLM:0010001 MBA:632 {CLM:0010002="0.27", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF acronym region."} property_value: CLM:0010003 CLM:5006973 {STATO:0000663="0.2777778"} property_value: CLM:0010003 CLM:5022193 {STATO:0000663="0.4878049"} property_value: IAO:0000028 "Astro-TE NN_2 Mcm6 (Mmus)" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIAAAFDQkdDMFUzMFZWOUpQUjYwVEpVAAIBNTIyMyBBc3Ryby1URSBOTl8yAAAEAQECgazGjoGWFSADhGpN%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%2BAAAABAAACFZGT0ZZUEZRR1JLVURRVVozRkYACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAVRMT0tXQ0w5NVJVMDNEOVBFVEcAAjczR1ZURFhERUdFMjdNMlhKTVQAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAgMA" xsd:string {name="Reference data on Allen Brain Cell Atlas"} property_value: seeAlso "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_30.h5ad" xsd:string {comment="Warning large data file!", name="h5ad data file for CS20230722_CLAS_30"} [Term] id: CL:4307044 name: Astro-TE NN_3 Cxcl5 astrocyte (Mmus) def: "A astrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Gja1 (Mmus), Cxcl5 (Mmus), Ddn (Mmus). It is distinguished from other Astro-TE NN_3 cells by expression of Cxcl5, Kif5a. These cells are located in the Hippocampal region, Isocortex, Olfactory areas, brain . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5224 Astro-TE NN_3." [https://doi.org/10.1038/s41586-023-06812-z] comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions. subset: human_subset subset: mouse_subset synonym: "5224 Astro-TE NN_3" EXACT [] is_a: CL:4301593 ! Astro-TE NN_3 astrocyte (Mmus) property_value: CLM:0010001 MBA:1080 {CLM:0010002="0.17", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF broad region."} property_value: CLM:0010001 MBA:315 {CLM:0010002="0.32", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF broad region."} property_value: CLM:0010001 MBA:698 {CLM:0010002="0.13", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF broad region."} property_value: CLM:0010001 MBA:997 {CLM:0010002="0.15", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF broad region."} property_value: CLM:0010003 CLM:5006974 {STATO:0000663="0.0"} property_value: CLM:0010003 CLM:5022194 {STATO:0000663="0.5851064"} property_value: IAO:0000028 "Astro-TE NN_3 Cxcl5 (Mmus)" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIAAAFDQkdDMFUzMFZWOUpQUjYwVEpVAAIBNTIyNCBBc3Ryby1URSBOTl8zAAAEAQECgazGjoGWFSADhGpN%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%2BAAAABAAACFZGT0ZZUEZRR1JLVURRVVozRkYACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAVRMT0tXQ0w5NVJVMDNEOVBFVEcAAjczR1ZURFhERUdFMjdNMlhKTVQAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAgMA" xsd:string {name="Reference data on Allen Brain Cell Atlas"} property_value: seeAlso "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_30.h5ad" xsd:string {comment="Warning large data file!", name="h5ad data file for CS20230722_CLAS_30"} [Term] id: CL:4307045 name: Astro-TE NN_3 Fam163a astrocyte (Mmus) def: "A astrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of S1pr1 (Mmus), Fam163a (Mmus), Kcnq3 (Mmus), Kcnq1ot1 (Mmus). It is distinguished from other Astro-TE NN_3 cells by expression of Fam163a, Nr2f1, Kcnq1ot1. These cells are located in the Isocortex, Olfactory areas . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5225 Astro-TE NN_3." [https://doi.org/10.1038/s41586-023-06812-z] comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions. subset: human_subset subset: mouse_subset synonym: "5225 Astro-TE NN_3" EXACT [] is_a: CL:4301593 ! Astro-TE NN_3 astrocyte (Mmus) property_value: CLM:0010001 MBA:315 {CLM:0010002="0.71", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF broad region."} property_value: CLM:0010001 MBA:698 {CLM:0010002="0.1", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF broad region."} property_value: CLM:0010003 CLM:5006975 {STATO:0000663="0.0862069"} property_value: CLM:0010003 CLM:5022195 {STATO:0000663="0.43650794"} property_value: IAO:0000028 "Astro-TE NN_3 Fam163a (Mmus)" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIAAAFDQkdDMFUzMFZWOUpQUjYwVEpVAAIBNTIyNSBBc3Ryby1URSBOTl8zAAAEAQECgazGjoGWFSADhGpN%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%2BAAAABAAACFZGT0ZZUEZRR1JLVURRVVozRkYACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAVRMT0tXQ0w5NVJVMDNEOVBFVEcAAjczR1ZURFhERUdFMjdNMlhKTVQAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAgMA" xsd:string {name="Reference data on Allen Brain Cell Atlas"} property_value: seeAlso "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_30.h5ad" xsd:string {comment="Warning large data file!", name="h5ad data file for CS20230722_CLAS_30"} [Term] id: CL:4307046 name: Astro-TE NN_3 Zic4 astrocyte (Mmus) def: "A astrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of S1pr1 (Mmus), Ranbp3l (Mmus), Emx2os (Mmus), Zic4 (Mmus). It is distinguished from other Astro-TE NN_3 cells by expression of Zic4. These cells are located in the Lateral septal complex, Isocortex, Olfactory areas , in or close to the regions: Lateral septal nucleus, rostral (rostroventral) part . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5226 Astro-TE NN_3." [https://doi.org/10.1038/s41586-023-06812-z] comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions. subset: human_subset subset: mouse_subset synonym: "5226 Astro-TE NN_3" EXACT [] is_a: CL:4301593 ! Astro-TE NN_3 astrocyte (Mmus) property_value: CLM:0010001 MBA:258 {CLM:0010002="0.29", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF acronym region."} property_value: CLM:0010001 MBA:275 {CLM:0010002="0.39", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF broad region."} property_value: CLM:0010001 MBA:315 {CLM:0010002="0.3", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF broad region."} property_value: CLM:0010001 MBA:698 {CLM:0010002="0.19", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF broad region."} property_value: CLM:0010003 CLM:5006976 {STATO:0000663="0.0"} property_value: CLM:0010003 CLM:5022196 {STATO:0000663="0.5254777"} property_value: IAO:0000028 "Astro-TE NN_3 Zic4 (Mmus)" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIAAAFDQkdDMFUzMFZWOUpQUjYwVEpVAAIBNTIyNiBBc3Ryby1URSBOTl8zAAAEAQECgazGjoGWFSADhGpN%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%2BAAAABAAACFZGT0ZZUEZRR1JLVURRVVozRkYACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAVRMT0tXQ0w5NVJVMDNEOVBFVEcAAjczR1ZURFhERUdFMjdNMlhKTVQAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAgMA" xsd:string {name="Reference data on Allen Brain Cell Atlas"} property_value: seeAlso "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_30.h5ad" xsd:string {comment="Warning large data file!", name="h5ad data file for CS20230722_CLAS_30"} [Term] id: CL:4307047 name: Astro-TE NN_3 Crym astrocyte (Mmus) def: "A astrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of S1pr1 (Mmus), Crym (Mmus), Grin2c (Mmus). It is distinguished from other Astro-TE NN_3 cells by expression of Crym, Gabbr2. These cells are located in the Striatum dorsal region, Striatum ventral region , in or close to the regions: Nucleus accumbens, Caudoputamen . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5227 Astro-TE NN_3." [https://doi.org/10.1038/s41586-023-06812-z] comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions. subset: human_subset subset: mouse_subset synonym: "5227 Astro-TE NN_3" EXACT [] is_a: CL:4301593 ! Astro-TE NN_3 astrocyte (Mmus) property_value: CLM:0010001 MBA:485 {CLM:0010002="0.7", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF broad region."} property_value: CLM:0010001 MBA:493 {CLM:0010002="0.2", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF broad region."} property_value: CLM:0010001 MBA:56 {CLM:0010002="0.15", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF acronym region."} property_value: CLM:0010001 MBA:672 {CLM:0010002="0.7", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF acronym region."} property_value: CLM:0010003 CLM:5006977 {STATO:0000663="0.0"} property_value: CLM:0010003 CLM:5022197 {STATO:0000663="0.7017544"} property_value: IAO:0000028 "Astro-TE NN_3 Crym (Mmus)" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIAAAFDQkdDMFUzMFZWOUpQUjYwVEpVAAIBNTIyNyBBc3Ryby1URSBOTl8zAAAEAQECgazGjoGWFSADhGpN%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%2BAAAABAAACFZGT0ZZUEZRR1JLVURRVVozRkYACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAVRMT0tXQ0w5NVJVMDNEOVBFVEcAAjczR1ZURFhERUdFMjdNMlhKTVQAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAgMA" xsd:string {name="Reference data on Allen Brain Cell Atlas"} property_value: seeAlso "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_30.h5ad" xsd:string {comment="Warning large data file!", name="h5ad data file for CS20230722_CLAS_30"} [Term] id: CL:4307048 name: Astro-TE NN_4 astrocyte (Mmus) def: "A astrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of S1pr1 (Mmus), Thbs4 (Mmus), Gm29683 (Mmus), Slc39a12 (Mmus). It is distinguished from other Astro-TE NN cells by expression of Gm29683. These cells are located in the Cortical subplate, brain , in or close to the regions: Lateral amygdalar nucleus, external capsule . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5228 Astro-TE NN_4." [https://doi.org/10.1038/s41586-023-06812-z] comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions. subset: human_subset subset: mouse_subset synonym: "1164 Astro-TE NN_4" EXACT [] synonym: "5228 Astro-TE NN_4" EXACT [] is_a: CL:4300359 ! astrocyte of cerebrum (Mmus) property_value: CLM:0010001 MBA:131 {CLM:0010002="0.13", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF acronym region."} property_value: CLM:0010001 MBA:579 {CLM:0010002="0.14", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF acronym region."} property_value: CLM:0010001 MBA:703 {CLM:0010002="0.25", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF broad region."} property_value: CLM:0010001 MBA:997 {CLM:0010002="0.55", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF broad region."} property_value: CLM:0010003 CLM:5006978 {STATO:0000663="0.09259259"} property_value: CLM:0010003 CLM:5022198 {STATO:0000663="0.5102041"} property_value: IAO:0000028 "Astro-TE NN_4 (Mmus)" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIAAAFDQkdDMFUzMFZWOUpQUjYwVEpVAAIBNTIyOCBBc3Ryby1URSBOTl80AAAEAQECgazGjoGWFSADhGpN%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%2BAAAABAAACFZGT0ZZUEZRR1JLVURRVVozRkYACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAVRMT0tXQ0w5NVJVMDNEOVBFVEcAAjczR1ZURFhERUdFMjdNMlhKTVQAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAgMA" xsd:string {name="Reference data on Allen Brain Cell Atlas"} property_value: seeAlso "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_30.h5ad" xsd:string {comment="Warning large data file!", name="h5ad data file for CS20230722_CLAS_30"} [Term] id: CL:4307049 name: Astro-TE NN_5 Hs3st3a1 astrocyte (Mmus) def: "A astrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of S1pr1 (Mmus), Thbs4 (Mmus), Hs3st3a1 (Mmus), Sfrp1 (Mmus). It is distinguished from other Astro-TE NN_5 cells by expression of Hs3st3a1, Sfrp1. These cells are located in the Olfactory areas, brain , in or close to the regions: Anterior olfactory nucleus, corpus callosum, body, lateral ventricle, corpus callosum, anterior forceps . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5229 Astro-TE NN_5." [https://doi.org/10.1038/s41586-023-06812-z] comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions. subset: human_subset subset: mouse_subset synonym: "5229 Astro-TE NN_5" EXACT [] is_a: CL:4301595 ! Astro-TE NN_5 astrocyte (Mmus) property_value: CLM:0010001 MBA:159 {CLM:0010002="0.15", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF acronym region."} property_value: CLM:0010001 MBA:484682516 {CLM:0010002="0.19", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF acronym region."} property_value: CLM:0010001 MBA:698 {CLM:0010002="0.39", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF broad region."} property_value: CLM:0010001 MBA:81 {CLM:0010002="0.13", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF acronym region."} property_value: CLM:0010001 MBA:956 {CLM:0010002="0.11", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF acronym region."} property_value: CLM:0010001 MBA:997 {CLM:0010002="0.58", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF broad region."} property_value: CLM:0010003 CLM:5006979 {STATO:0000663="0.0"} property_value: CLM:0010003 CLM:5022199 {STATO:0000663="0.16129032"} property_value: IAO:0000028 "Astro-TE NN_5 Hs3st3a1 (Mmus)" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIAAAFDQkdDMFUzMFZWOUpQUjYwVEpVAAIBNTIyOSBBc3Ryby1URSBOTl81AAAEAQECgazGjoGWFSADhGpN%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%2BAAAABAAACFZGT0ZZUEZRR1JLVURRVVozRkYACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAVRMT0tXQ0w5NVJVMDNEOVBFVEcAAjczR1ZURFhERUdFMjdNMlhKTVQAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAgMA" xsd:string {name="Reference data on Allen Brain Cell Atlas"} property_value: seeAlso "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_30.h5ad" xsd:string {comment="Warning large data file!", name="h5ad data file for CS20230722_CLAS_30"} [Term] id: CL:4307050 name: Astro-TE NN_5 Adamts18 astrocyte (Mmus) def: "A astrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of S1pr1 (Mmus), Adamts18 (Mmus), Crym (Mmus). It is distinguished from other Astro-TE NN_5 cells by expression of Adamts18. These cells are located in the Lateral septal complex, Striatum dorsal region, brain , in or close to the regions: Nucleus accumbens, Caudoputamen, lateral ventricle . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5230 Astro-TE NN_5." [https://doi.org/10.1038/s41586-023-06812-z] comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions. subset: human_subset subset: mouse_subset synonym: "5230 Astro-TE NN_5" EXACT [] is_a: CL:4301595 ! Astro-TE NN_5 astrocyte (Mmus) property_value: CLM:0010001 MBA:275 {CLM:0010002="0.12", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF broad region."} property_value: CLM:0010001 MBA:485 {CLM:0010002="0.3", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF broad region."} property_value: CLM:0010001 MBA:56 {CLM:0010002="0.11", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF acronym region."} property_value: CLM:0010001 MBA:672 {CLM:0010002="0.3", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF acronym region."} property_value: CLM:0010001 MBA:81 {CLM:0010002="0.39", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF acronym region."} property_value: CLM:0010001 MBA:997 {CLM:0010002="0.43", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF broad region."} property_value: CLM:0010003 CLM:5006980 {STATO:0000663="0.09259259"} property_value: CLM:0010003 CLM:5022200 {STATO:0000663="0.7474227"} property_value: IAO:0000028 "Astro-TE NN_5 Adamts18 (Mmus)" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIAAAFDQkdDMFUzMFZWOUpQUjYwVEpVAAIBNTIzMCBBc3Ryby1URSBOTl81AAAEAQECgazGjoGWFSADhGpN%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%2BAAAABAAACFZGT0ZZUEZRR1JLVURRVVozRkYACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAVRMT0tXQ0w5NVJVMDNEOVBFVEcAAjczR1ZURFhERUdFMjdNMlhKTVQAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAgMA" xsd:string {name="Reference data on Allen Brain Cell Atlas"} property_value: seeAlso "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_30.h5ad" xsd:string {comment="Warning large data file!", name="h5ad data file for CS20230722_CLAS_30"} [Term] id: CL:4307051 name: Astro-OLF NN_1 Greb1 astrocyte (Mmus) def: "A astrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Gja1 (Mmus), Chrdl1 (Mmus), Ano1 (Mmus), Il33 (Mmus). It is distinguished from other Astro-OLF NN_1 cells by expression of Greb1, Il33. These cells are located in the Olfactory areas, brain , in or close to the regions: Main olfactory bulb . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5231 Astro-OLF NN_1." [https://doi.org/10.1038/s41586-023-06812-z] comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions. subset: human_subset subset: mouse_subset synonym: "5231 Astro-OLF NN_1" EXACT [] is_a: CL:4301596 ! Astro-OLF NN_1 astrocyte (Mmus) property_value: CLM:0010001 MBA:507 {CLM:0010002="0.1", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF acronym region."} property_value: CLM:0010001 MBA:698 {CLM:0010002="0.32", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF broad region."} property_value: CLM:0010001 MBA:997 {CLM:0010002="0.64", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF broad region."} property_value: CLM:0010003 CLM:5006981 {STATO:0000663="0.09259259"} property_value: CLM:0010003 CLM:5022201 {STATO:0000663="0.42372882"} property_value: IAO:0000028 "Astro-OLF NN_1 Greb1 (Mmus)" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#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%2BDggl%2FA4SgGoeExD3ZBDJOUVRJRTdUQU1QOFBRQUhPNFAABYGvpkqB6awOgaCBR4CS1egGAAcAAAUABgEBAkNCR0MwVTMwVlY5SlBSNjBUSlUAA34AAAAEAAAIVkZPRllQRlFHUktVRFFVWjNGRgAJTFZEQkpBVzhCSTVZU1MxUVVCRwAKAAsBVExPS1dDTDk1UlUwM0Q5UEVURwACNzNHVlREWERFR0UyN00yWEpNVAADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAACAwA%3D" xsd:string {name="Reference data on Allen Brain Cell Atlas"} property_value: seeAlso "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_30.h5ad" xsd:string {comment="Warning large data file!", name="h5ad data file for CS20230722_CLAS_30"} [Term] id: CL:4307052 name: Astro-OLF NN_1 Stk32a astrocyte (Mmus) def: "A astrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Aqp4 (Mmus), Prss23 (Mmus), Stk32a (Mmus). It is distinguished from other Astro-OLF NN_1 cells by expression of Stk32a. These cells are located in the Olfactory areas, brain , in or close to the regions: olfactory nerve layer of main olfactory bulb, Main olfactory bulb . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5232 Astro-OLF NN_1." [https://doi.org/10.1038/s41586-023-06812-z] comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions. subset: human_subset subset: mouse_subset synonym: "5232 Astro-OLF NN_1" EXACT [] is_a: CL:4301596 ! Astro-OLF NN_1 astrocyte (Mmus) property_value: CLM:0010001 MBA:1016 {CLM:0010002="0.31", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF acronym region."} property_value: CLM:0010001 MBA:507 {CLM:0010002="0.26", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF acronym region."} property_value: CLM:0010001 MBA:698 {CLM:0010002="0.44", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF broad region."} property_value: CLM:0010001 MBA:997 {CLM:0010002="0.56", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF broad region."} property_value: CLM:0010003 CLM:5006982 {STATO:0000663="0.24193548"} property_value: CLM:0010003 CLM:5022202 {STATO:0000663="0.9"} property_value: IAO:0000028 "Astro-OLF NN_1 Stk32a (Mmus)" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#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%2BDggl%2FA4SgGoeExD3ZBDJOUVRJRTdUQU1QOFBRQUhPNFAABYGvpkqB6awOgaCBR4CS1egGAAcAAAUABgEBAkNCR0MwVTMwVlY5SlBSNjBUSlUAA34AAAAEAAAIVkZPRllQRlFHUktVRFFVWjNGRgAJTFZEQkpBVzhCSTVZU1MxUVVCRwAKAAsBVExPS1dDTDk1UlUwM0Q5UEVURwACNzNHVlREWERFR0UyN00yWEpNVAADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAACAwA%3D" xsd:string {name="Reference data on Allen Brain Cell Atlas"} property_value: seeAlso "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_30.h5ad" xsd:string {comment="Warning large data file!", name="h5ad data file for CS20230722_CLAS_30"} [Term] id: CL:4307053 name: Astro-OLF NN_2 Slc25a34 astrocyte (Mmus) def: "A astrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Aqp4 (Mmus), Hs3st3a1 (Mmus), Slc25a34 (Mmus), C4b (Mmus). It is distinguished from other Astro-OLF NN_2 cells by expression of Slc25a34, C4b. These cells are located in the Olfactory areas, brain , in or close to the regions: Main olfactory bulb, outer plexiform layer, Main olfactory bulb . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5233 Astro-OLF NN_2." [https://doi.org/10.1038/s41586-023-06812-z] comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions. subset: human_subset subset: mouse_subset synonym: "5233 Astro-OLF NN_2" EXACT [] is_a: CL:4301597 ! Astro-OLF NN_2 astrocyte (Mmus) property_value: CLM:0010001 MBA:244 {CLM:0010002="0.15", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF acronym region."} property_value: CLM:0010001 MBA:507 {CLM:0010002="0.11", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF acronym region."} property_value: CLM:0010001 MBA:698 {CLM:0010002="0.44", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF broad region."} property_value: CLM:0010001 MBA:997 {CLM:0010002="0.51", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF broad region."} property_value: CLM:0010003 CLM:5006983 {STATO:0000663="0.0"} property_value: CLM:0010003 CLM:5022203 {STATO:0000663="0.09259259"} property_value: IAO:0000028 "Astro-OLF NN_2 Slc25a34 (Mmus)" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#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%2BDggl%2FA4SgGoeExD3ZBDJOUVRJRTdUQU1QOFBRQUhPNFAABYGvpkqB6awOgaCBR4CS1egGAAcAAAUABgEBAkNCR0MwVTMwVlY5SlBSNjBUSlUAA34AAAAEAAAIVkZPRllQRlFHUktVRFFVWjNGRgAJTFZEQkpBVzhCSTVZU1MxUVVCRwAKAAsBVExPS1dDTDk1UlUwM0Q5UEVURwACNzNHVlREWERFR0UyN00yWEpNVAADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAACAwA%3D" xsd:string {name="Reference data on Allen Brain Cell Atlas"} property_value: seeAlso "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_30.h5ad" xsd:string {comment="Warning large data file!", name="h5ad data file for CS20230722_CLAS_30"} [Term] id: CL:4307054 name: Astro-OLF NN_2 Alk astrocyte (Mmus) def: "A astrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of S1pr1 (Mmus), Chrdl1 (Mmus), Sfrp1 (Mmus), Atp13a4 (Mmus). It is distinguished from other Astro-OLF NN_2 cells by expression of Alk, Atp13a4. These cells are located in the Olfactory areas , in or close to the regions: Anterior olfactory nucleus, Main olfactory bulb, granule layer, Main olfactory bulb, mitral layer . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5234 Astro-OLF NN_2." [https://doi.org/10.1038/s41586-023-06812-z] comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions. subset: human_subset subset: mouse_subset synonym: "5234 Astro-OLF NN_2" EXACT [] is_a: CL:4301597 ! Astro-OLF NN_2 astrocyte (Mmus) property_value: CLM:0010001 MBA:159 {CLM:0010002="0.29", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF acronym region."} property_value: CLM:0010001 MBA:220 {CLM:0010002="0.29", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF acronym region."} property_value: CLM:0010001 MBA:236 {CLM:0010002="0.14", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF acronym region."} property_value: CLM:0010001 MBA:698 {CLM:0010002="1.0", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF broad region."} property_value: CLM:0010003 CLM:5006984 {STATO:0000663="0.1724138"} property_value: CLM:0010003 CLM:5022204 {STATO:0000663="0.25641027"} property_value: IAO:0000028 "Astro-OLF NN_2 Alk (Mmus)" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#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%2BDggl%2FA4SgGoeExD3ZBDJOUVRJRTdUQU1QOFBRQUhPNFAABYGvpkqB6awOgaCBR4CS1egGAAcAAAUABgEBAkNCR0MwVTMwVlY5SlBSNjBUSlUAA34AAAAEAAAIVkZPRllQRlFHUktVRFFVWjNGRgAJTFZEQkpBVzhCSTVZU1MxUVVCRwAKAAsBVExPS1dDTDk1UlUwM0Q5UEVURwACNzNHVlREWERFR0UyN00yWEpNVAADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAACAwA%3D" xsd:string {name="Reference data on Allen Brain Cell Atlas"} property_value: seeAlso "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_30.h5ad" xsd:string {comment="Warning large data file!", name="h5ad data file for CS20230722_CLAS_30"} [Term] id: CL:4307055 name: Astro-OLF NN_3 Ecrg4 astrocyte (Mmus) def: "A astrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of C230072F16Rik (Mmus), Dipk1c (Mmus), Ecrg4 (Mmus). It is distinguished from other Astro-OLF NN_3 cells by expression of Ecrg4. These cells are located in the Olfactory areas , in or close to the regions: Main olfactory bulb, granule layer . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5235 Astro-OLF NN_3." [https://doi.org/10.1038/s41586-023-06812-z] comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions. subset: human_subset subset: mouse_subset synonym: "5235 Astro-OLF NN_3" EXACT [] is_a: CL:4301598 ! Astro-OLF NN_3 astrocyte (Mmus) property_value: CLM:0010001 MBA:220 {CLM:0010002="0.63", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF acronym region."} property_value: CLM:0010001 MBA:698 {CLM:0010002="0.9", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF broad region."} property_value: CLM:0010003 CLM:5006985 {STATO:0000663="0.35714287"} property_value: CLM:0010003 CLM:5022205 {STATO:0000663="0.71428573"} property_value: IAO:0000028 "Astro-OLF NN_3 Ecrg4 (Mmus)" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#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%2BDggl%2FA4SgGoeExD3ZBDJOUVRJRTdUQU1QOFBRQUhPNFAABYGvpkqB6awOgaCBR4CS1egGAAcAAAUABgEBAkNCR0MwVTMwVlY5SlBSNjBUSlUAA34AAAAEAAAIVkZPRllQRlFHUktVRFFVWjNGRgAJTFZEQkpBVzhCSTVZU1MxUVVCRwAKAAsBVExPS1dDTDk1UlUwM0Q5UEVURwACNzNHVlREWERFR0UyN00yWEpNVAADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAACAwA%3D" xsd:string {name="Reference data on Allen Brain Cell Atlas"} property_value: seeAlso "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_30.h5ad" xsd:string {comment="Warning large data file!", name="h5ad data file for CS20230722_CLAS_30"} [Term] id: CL:4307056 name: Astro-OLF NN_3 Sfrp1 astrocyte (Mmus) def: "A astrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of S1pr1 (Mmus), 6530411M01Rik (Mmus), Sfrp1 (Mmus), Aqp4 (Mmus). It is distinguished from other Astro-OLF NN_3 cells by expression of Sfrp1, Aqp4. These cells are located in the Olfactory areas , in or close to the regions: Main olfactory bulb, granule layer, brain . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5236 Astro-OLF NN_3." [https://doi.org/10.1038/s41586-023-06812-z] comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions. subset: human_subset subset: mouse_subset synonym: "5236 Astro-OLF NN_3" EXACT [] is_a: CL:4301598 ! Astro-OLF NN_3 astrocyte (Mmus) property_value: CLM:0010001 MBA:220 {CLM:0010002="0.52", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF acronym region."} property_value: CLM:0010001 MBA:698 {CLM:0010002="0.84", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF broad region."} property_value: CLM:0010001 MBA:997 {CLM:0010002="0.16", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF acronym region."} property_value: CLM:0010003 CLM:5006986 {STATO:0000663="0.24193548"} property_value: CLM:0010003 CLM:5022206 {STATO:0000663="0.14705883"} property_value: IAO:0000028 "Astro-OLF NN_3 Sfrp1 (Mmus)" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#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%2BDggl%2FA4SgGoeExD3ZBDJOUVRJRTdUQU1QOFBRQUhPNFAABYGvpkqB6awOgaCBR4CS1egGAAcAAAUABgEBAkNCR0MwVTMwVlY5SlBSNjBUSlUAA34AAAAEAAAIVkZPRllQRlFHUktVRFFVWjNGRgAJTFZEQkpBVzhCSTVZU1MxUVVCRwAKAAsBVExPS1dDTDk1UlUwM0Q5UEVURwACNzNHVlREWERFR0UyN00yWEpNVAADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAACAwA%3D" xsd:string {name="Reference data on Allen Brain Cell Atlas"} property_value: seeAlso "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_30.h5ad" xsd:string {comment="Warning large data file!", name="h5ad data file for CS20230722_CLAS_30"} [Term] id: CL:4307063 name: Tanycyte NN_1 Cnmd tanycyte of subfornical organ (Mmus) def: "A tanycyte of subfornical organ of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Cnmd (Mmus), Sfta3-ps (Mmus). It is distinguished from other Tanycyte NN_1 cells by expression of Cnmd. These cells are located in the brain , in or close to the regions: choroid plexus, third ventricle . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5243 Tanycyte NN_1." [https://doi.org/10.1038/s41586-023-06812-z] comment: Rationale for assigning this type to reference data: Mapping to tanycyte of subfornical organ based on spatial transcriptomics evidence. Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions. subset: human_subset subset: mouse_subset synonym: "5243 Tanycyte NN_1" EXACT [] is_a: CL:0008042 ! tanycyte of subfornical organ is_a: CL:4301602 ! Tanycyte NN_1 tanycyte (Mmus) property_value: CLM:0010001 MBA:108 {CLM:0010002="0.58", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF acronym region."} property_value: CLM:0010001 MBA:129 {CLM:0010002="0.24", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF acronym region."} property_value: CLM:0010001 MBA:997 {CLM:0010002="0.88", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF broad region."} property_value: CLM:0010003 CLM:5006993 {STATO:0000663="0.82191783"} property_value: CLM:0010003 CLM:5022213 {STATO:0000663="0.9347826"} property_value: IAO:0000028 "Tanycyte NN_1 Cnmd (Mmus)" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIAAAFDQkdDMFUzMFZWOUpQUjYwVEpVAAIBNTI0MyBUYW55Y3l0ZSBOTl8xAAAEAQECgazGjoGWFSADhGpN%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%2BAAAABAAACFZGT0ZZUEZRR1JLVURRVVozRkYACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAVRMT0tXQ0w5NVJVMDNEOVBFVEcAAjczR1ZURFhERUdFMjdNMlhKTVQAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAgMA" xsd:string {name="Reference data on Allen Brain Cell Atlas"} property_value: seeAlso "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_30.h5ad" xsd:string {comment="Warning large data file!", name="h5ad data file for CS20230722_CLAS_30"} [Term] id: CL:4307064 name: Tanycyte NN_1 Glp1r tanycyte (Mmus) def: "A tanycyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of C230072F16Rik (Mmus), Glp1r (Mmus). It is distinguished from other Tanycyte NN_1 cells by expression of Glp1r. These cells are located in the Hypothalamus, brain , in or close to the regions: Anteroventral periventricular nucleus . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5244 Tanycyte NN_1." [https://doi.org/10.1038/s41586-023-06812-z] comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions. subset: human_subset subset: mouse_subset synonym: "5244 Tanycyte NN_1" EXACT [] is_a: CL:4301602 ! Tanycyte NN_1 tanycyte (Mmus) property_value: CLM:0010001 MBA:1097 {CLM:0010002="0.34", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF broad region."} property_value: CLM:0010001 MBA:272 {CLM:0010002="0.34", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF acronym region."} property_value: CLM:0010001 MBA:997 {CLM:0010002="0.61", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF broad region."} property_value: CLM:0010003 CLM:5006994 {STATO:0000663="0.7017544"} property_value: CLM:0010003 CLM:5022214 {STATO:0000663="0.8208955"} property_value: IAO:0000028 "Tanycyte NN_1 Glp1r (Mmus)" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIAAAFDQkdDMFUzMFZWOUpQUjYwVEpVAAIBNTI0NCBUYW55Y3l0ZSBOTl8xAAAEAQECgazGjoGWFSADhGpN%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%2BAAAABAAACFZGT0ZZUEZRR1JLVURRVVozRkYACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAVRMT0tXQ0w5NVJVMDNEOVBFVEcAAjczR1ZURFhERUdFMjdNMlhKTVQAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAgMA" xsd:string {name="Reference data on Allen Brain Cell Atlas"} property_value: seeAlso "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_30.h5ad" xsd:string {comment="Warning large data file!", name="h5ad data file for CS20230722_CLAS_30"} [Term] id: CL:4307065 name: Tanycyte NN_2 Mylk3 alpha1-tanycyte (Mmus) def: "A alpha1-tanycyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Dynlrb2 (Mmus), Mylk3 (Mmus), Sfta3-ps (Mmus). It is distinguished from other Tanycyte NN_2 cells by expression of Mylk3. It is glutamatergic (inferred from expression of Slc17a8). These cells are located in the Hypothalamus , in or close to the regions: Periventricular hypothalamic nucleus, intermediate part . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5245 Tanycyte NN_2." [https://doi.org/10.1038/s41586-023-06812-z] comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions. subset: human_subset subset: mouse_subset synonym: "5245 Tanycyte NN_2" EXACT [] is_a: CL:1100001 ! secretory epithelial cell is_a: CL:4042017 {evidence="http://identifiers.org/ncbigene/216227"} ! alpha1-tanycyte is_a: CL:4301603 ! Tanycyte NN_2 tanycyte (Mmus) relationship: RO:0002215 GO:0061535 {comment="Inferred to be glutamate secretion, neurotransmission based on expression of Slc17a8"} ! capable of glutamate secretion, neurotransmission property_value: CLM:0010001 MBA:1097 {CLM:0010002="0.92", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF broad region."} property_value: CLM:0010001 MBA:118 {CLM:0010002="0.88", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF acronym region."} property_value: CLM:0010003 CLM:5006995 {STATO:0000663="0.24193548"} property_value: CLM:0010003 CLM:5022215 {STATO:0000663="0.78313255"} property_value: IAO:0000028 "Tanycyte NN_2 Mylk3 (Mmus)" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIAAAFDQkdDMFUzMFZWOUpQUjYwVEpVAAIBNTI0NSBUYW55Y3l0ZSBOTl8yAAAEAQECgazGjoGWFSADhGpN%2FYRYGE0ABQAGAQECQ0JHQzBVMzBWVjlKUFI2MFRKVQADfgAAAAQAAAhHNEk0R0ZKWEpCOUFUWjNQVFgxAAlMVkRCSkFXOEJJNVlTUzFRVUJHAAoACwFub25lAAJub25lAAMBBAEAAiMwMDAwMDAAA8gBAAUBAQIjMDAwMDAwAAPIAQAAAAFLOUpOMjNQMjRLUUNHSzlVNzVBAAJIU1laUFpXMTY2OVU4MjFCV1lQAAMEAUZTMDBEWFYwVDlSMVg5Rko0UUUAAgAAAVFZNVM4S01PNUhMSlVGMFAwMEsAAgAAATE1Qks0N0RDSU9GMVNMTFVXOVAAAgAAAUNCR0MwVTMwVlY5SlBSNjBUSlUAAgE1MjQ1IFRhbnljeXRlIE5OXzIAAAQBAAKEUL8fg4IJfwOEoBqHhMQ92QQyTlFUSUU3VEFNUDhQUUFITzRQAAWBr6ZKgemsDoGggUeAktXoBgAHAAAFAAYBAQJDQkdDMFUzMFZWOUpQUjYwVEpVAAN%2BAAAABAAACFZGT0ZZUEZRR1JLVURRVVozRkYACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAVRMT0tXQ0w5NVJVMDNEOVBFVEcAAjczR1ZURFhERUdFMjdNMlhKTVQAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAgMA" xsd:string {name="Reference data on Allen Brain Cell Atlas"} property_value: seeAlso "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_30.h5ad" xsd:string {comment="Warning large data file!", name="h5ad data file for CS20230722_CLAS_30"} [Term] id: CL:4307066 name: Tanycyte NN_2 Mroh5 alpha1-tanycyte (Mmus) def: "A alpha1-tanycyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Ccdc170 (Mmus), Nkx2-4 (Mmus), Dock8 (Mmus). It is distinguished from other Tanycyte NN_2 cells by expression of Mroh5. These cells are located in the Hypothalamus, brain , in or close to the regions: Periventricular hypothalamic nucleus, intermediate part, third ventricle, Arcuate hypothalamic nucleus . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5246 Tanycyte NN_2." [https://doi.org/10.1038/s41586-023-06812-z] comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions. subset: human_subset subset: mouse_subset synonym: "5246 Tanycyte NN_2" EXACT [] is_a: CL:4042017 ! alpha1-tanycyte is_a: CL:4301603 ! Tanycyte NN_2 tanycyte (Mmus) property_value: CLM:0010001 MBA:1097 {CLM:0010002="0.73", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF broad region."} property_value: CLM:0010001 MBA:118 {CLM:0010002="0.47", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF acronym region."} property_value: CLM:0010001 MBA:129 {CLM:0010002="0.24", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF acronym region."} property_value: CLM:0010001 MBA:223 {CLM:0010002="0.11", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF acronym region."} property_value: CLM:0010001 MBA:997 {CLM:0010002="0.27", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF broad region."} property_value: CLM:0010003 CLM:5006996 {STATO:0000663="0.18292683"} property_value: CLM:0010003 CLM:5022216 {STATO:0000663="0.6321839"} property_value: IAO:0000028 "Tanycyte NN_2 Mroh5 (Mmus)" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIAAAFDQkdDMFUzMFZWOUpQUjYwVEpVAAIBNTI0NiBUYW55Y3l0ZSBOTl8yAAAEAQECgazGjoGWFSADhGpN%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%2BAAAABAAACFZGT0ZZUEZRR1JLVURRVVozRkYACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAVRMT0tXQ0w5NVJVMDNEOVBFVEcAAjczR1ZURFhERUdFMjdNMlhKTVQAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAgMA" xsd:string {name="Reference data on Allen Brain Cell Atlas"} property_value: seeAlso "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_30.h5ad" xsd:string {comment="Warning large data file!", name="h5ad data file for CS20230722_CLAS_30"} [Term] id: CL:4307067 name: alpha2-tanycyte (Mmus) def: "A alpha2-tanycyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Pdzph1 (Mmus), Wdr63 (Mmus), Dscaml1 (Mmus), P3h2 (Mmus). It is distinguished from other Tanycyte NN_2 cells by expression of Dscaml1, P3h2. These cells are located in the Hypothalamus , in or close to the regions: Periventricular hypothalamic nucleus, posterior part, Arcuate hypothalamic nucleus . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5247 Tanycyte NN_2." [https://doi.org/10.1038/s41586-023-06812-z] comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions. subset: human_subset subset: mouse_subset synonym: "5247 Tanycyte NN_2" EXACT [] is_a: CL:4042018 ! alpha2-tanycyte is_a: CL:4301603 ! Tanycyte NN_2 tanycyte (Mmus) property_value: CLM:0010001 MBA:1097 {CLM:0010002="0.94", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF broad region."} property_value: CLM:0010001 MBA:126 {CLM:0010002="0.29", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF acronym region."} property_value: CLM:0010001 MBA:223 {CLM:0010002="0.6", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF acronym region."} property_value: CLM:0010003 CLM:5006997 {STATO:0000663="0.0"} property_value: CLM:0010003 CLM:5022217 {STATO:0000663="0.61403507"} property_value: IAO:0000028 "Tanycyte NN_2 Dscaml1 (Mmus)" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIAAAFDQkdDMFUzMFZWOUpQUjYwVEpVAAIBNTI0NyBUYW55Y3l0ZSBOTl8yAAAEAQECgazGjoGWFSADhGpN%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%2BAAAABAAACFZGT0ZZUEZRR1JLVURRVVozRkYACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAVRMT0tXQ0w5NVJVMDNEOVBFVEcAAjczR1ZURFhERUdFMjdNMlhKTVQAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAgMA" xsd:string {name="Reference data on Allen Brain Cell Atlas"} property_value: seeAlso "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_30.h5ad" xsd:string {comment="Warning large data file!", name="h5ad data file for CS20230722_CLAS_30"} [Term] id: CL:4307068 name: Tanycyte NN_2 Otx2 tanycyte (Mmus) def: "A tanycyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Ccdc146 (Mmus), Tbx3 (Mmus), Otx2 (Mmus). It is distinguished from other Tanycyte NN_2 cells by expression of Otx2, Nkx2-4. These cells are located in the Hypothalamus, brain , in or close to the regions: Periventricular hypothalamic nucleus, posterior part, third ventricle . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5248 Tanycyte NN_2." [https://doi.org/10.1038/s41586-023-06812-z] comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions. subset: human_subset subset: mouse_subset synonym: "5248 Tanycyte NN_2" EXACT [] is_a: CL:4301603 ! Tanycyte NN_2 tanycyte (Mmus) property_value: CLM:0010001 MBA:1097 {CLM:0010002="0.69", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF broad region."} property_value: CLM:0010001 MBA:126 {CLM:0010002="0.69", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF acronym region."} property_value: CLM:0010001 MBA:129 {CLM:0010002="0.31", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF acronym region."} property_value: CLM:0010001 MBA:997 {CLM:0010002="0.31", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF broad region."} property_value: CLM:0010003 CLM:5006998 {STATO:0000663="0.44642857"} property_value: CLM:0010003 CLM:5022218 {STATO:0000663="0.5681818"} property_value: IAO:0000028 "Tanycyte NN_2 Otx2 (Mmus)" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIAAAFDQkdDMFUzMFZWOUpQUjYwVEpVAAIBNTI0OCBUYW55Y3l0ZSBOTl8yAAAEAQECgazGjoGWFSADhGpN%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%2BAAAABAAACFZGT0ZZUEZRR1JLVURRVVozRkYACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAVRMT0tXQ0w5NVJVMDNEOVBFVEcAAjczR1ZURFhERUdFMjdNMlhKTVQAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAgMA" xsd:string {name="Reference data on Allen Brain Cell Atlas"} property_value: seeAlso "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_30.h5ad" xsd:string {comment="Warning large data file!", name="h5ad data file for CS20230722_CLAS_30"} [Term] id: CL:4307069 name: beta1-tancyte (Mmus) def: "A beta1-tanycyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Gpr50 (Mmus), Frzb (Mmus), Foxd2os (Mmus). It is distinguished from other Tanycyte NN_2 cells by expression of Col25a1, C230072F16Rik. These cells are located in the Hypothalamus, brain , in or close to the regions: third ventricle, Arcuate hypothalamic nucleus . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5249 Tanycyte NN_2." [https://doi.org/10.1038/s41586-023-06812-z] comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions. subset: human_subset subset: mouse_subset synonym: "5249 Tanycyte NN_2" EXACT [] is_a: CL:4042019 ! beta1-tanycyte is_a: CL:4301603 ! Tanycyte NN_2 tanycyte (Mmus) property_value: CLM:0010001 MBA:1097 {CLM:0010002="0.78", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF broad region."} property_value: CLM:0010001 MBA:129 {CLM:0010002="0.22", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF acronym region."} property_value: CLM:0010001 MBA:223 {CLM:0010002="0.76", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF acronym region."} property_value: CLM:0010001 MBA:997 {CLM:0010002="0.22", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF broad region."} property_value: CLM:0010003 CLM:5006999 {STATO:0000663="0.24193548"} property_value: CLM:0010003 CLM:5022219 {STATO:0000663="0.75842696"} property_value: IAO:0000028 "Tanycyte NN_2 Col25a1 (Mmus)" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIAAAFDQkdDMFUzMFZWOUpQUjYwVEpVAAIBNTI0OSBUYW55Y3l0ZSBOTl8yAAAEAQECgazGjoGWFSADhGpN%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%2BAAAABAAACFZGT0ZZUEZRR1JLVURRVVozRkYACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAVRMT0tXQ0w5NVJVMDNEOVBFVEcAAjczR1ZURFhERUdFMjdNMlhKTVQAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAgMA" xsd:string {name="Reference data on Allen Brain Cell Atlas"} property_value: seeAlso "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_30.h5ad" xsd:string {comment="Warning large data file!", name="h5ad data file for CS20230722_CLAS_30"} [Term] id: CL:4307070 name: beta-2 tanycyte (Mmus) def: "A beta2-tanycyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Fndc3c1 (Mmus), Ecrg4 (Mmus). It is distinguished from other Tanycyte NN cells by expression of Ecrg4. These cells are located in the Hypothalamus, brain , in or close to the regions: Median eminence, third ventricle, Arcuate hypothalamic nucleus . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5250 Tanycyte NN_3." [https://doi.org/10.1038/s41586-023-06812-z] comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions. subset: human_subset subset: mouse_subset synonym: "1174 Tanycyte NN_3" EXACT [] synonym: "5250 Tanycyte NN_3" EXACT [] is_a: CL:4042020 ! beta2-tanycyte is_a: CL:4300362 ! tanycyte (Mmus) property_value: CLM:0010001 MBA:10671 {CLM:0010002="0.46", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF acronym region."} property_value: CLM:0010001 MBA:1097 {CLM:0010002="0.75", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF broad region."} property_value: CLM:0010001 MBA:129 {CLM:0010002="0.19", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF acronym region."} property_value: CLM:0010001 MBA:223 {CLM:0010002="0.29", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF acronym region."} property_value: CLM:0010001 MBA:997 {CLM:0010002="0.25", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF broad region."} property_value: CLM:0010003 CLM:5007000 {STATO:0000663="0.7364341"} property_value: CLM:0010003 CLM:5022220 {STATO:0000663="0.47619048"} property_value: IAO:0000028 "Tanycyte NN_3 (Mmus)" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIAAAFDQkdDMFUzMFZWOUpQUjYwVEpVAAIBNTI1MCBUYW55Y3l0ZSBOTl8zAAAEAQECgazGjoGWFSADhGpN%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%2BAAAABAAACFZGT0ZZUEZRR1JLVURRVVozRkYACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAVRMT0tXQ0w5NVJVMDNEOVBFVEcAAjczR1ZURFhERUdFMjdNMlhKTVQAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAgMA" xsd:string {name="Reference data on Allen Brain Cell Atlas"} property_value: seeAlso "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_30.h5ad" xsd:string {comment="Warning large data file!", name="h5ad data file for CS20230722_CLAS_30"} [Term] id: CL:4307083 name: hypendemal cell (Mmus) def: "A hypendymal cell of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Sspo (Mmus), Wfdc2 (Mmus). It is distinguished from other Astro-Epen cells by expression of Sspo, Wfdc2. These cells are located in the Midbrain, brain , in or close to the regions: third ventricle, posterior commissure, Subcommissural organ . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5263 Hypendymal NN_1." [doi:10.3389/fncel.2015.00480, https://doi.org/10.1038/s41586-023-06812-z] comment: Rationale for assigning this type to reference data: Mapping of this cell set to the hypendemal cell type is supported by its location to the subcommisural organ (from spatial transcriptomics), its expression of Sspo and its general transcriptomic classification in a class (Astro-Epen) along with epdendymal cells, tanycytes and astrocytes. Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions. {xref="doi:10.3389/fncel.2015.00480"} subset: human_subset subset: mouse_subset synonym: "1177 Hypendymal NN_1" EXACT [] synonym: "324 Hypendymal NN" EXACT [] synonym: "5263 Hypendymal NN_1" EXACT [] is_a: CL:4023181 {evidence="http://identifiers.org/ncbigene/15186"} ! hypendymal cell property_value: CLM:0010001 MBA:129 {CLM:0010002="0.48", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF acronym region."} property_value: CLM:0010001 MBA:158 {CLM:0010002="0.11", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF acronym region."} property_value: CLM:0010001 MBA:313 {CLM:0010002="0.32", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF broad region."} property_value: CLM:0010001 MBA:599626923 {CLM:0010002="0.23", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF acronym region."} property_value: CLM:0010001 MBA:997 {CLM:0010002="0.68", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF broad region."} property_value: CLM:0010003 CLM:5007013 {STATO:0000663="0.87349397"} property_value: CLM:0010003 CLM:5007984 {STATO:0000663="0.89805824"} property_value: CLM:0010003 CLM:5022233 property_value: CLM:0010003 CLM:5029833 property_value: IAO:0000028 "Hypendymal NN (Mmus)" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIBMzI0IEh5cGVuZHltYWwgTk4AAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIAAAFDQkdDMFUzMFZWOUpQUjYwVEpVAAIAAAQBAQKBrMaOgZYVIAOEak39hFgYTQAFAAYBAQJRWTVTOEtNTzVITEpVRjBQMDBLAAN%2BAAAABAAACEc0STRHRkpYSkI5QVRaM1BUWDEACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAW5vbmUAAm5vbmUAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAUs5Sk4yM1AyNEtRQ0dLOVU3NUEAAkhTWVpQWlcxNjY5VTgyMUJXWVAAAwQBRlMwMERYVjBUOVIxWDlGSjRRRQACAAABUVk1UzhLTU81SExKVUYwUDAwSwACATMyNCBIeXBlbmR5bWFsIE5OAAABMTVCSzQ3RENJT0YxU0xMVVc5UAACAAABQ0JHQzBVMzBWVjlKUFI2MFRKVQACAAAEAQAChFC%2FH4OCCX8DhKAah4TEPdkEMk5RVElFN1RBTVA4UFFBSE80UAAFga%2BmSoHprA6BoIFHgJLV6AYABwAABQAGAQECUVk1UzhLTU81SExKVUYwUDAwSwADfgAAAAQAAAhWRk9GWVBGUUdSS1VEUVVaM0ZGAAlMVkRCSkFXOEJJNVlTUzFRVUJHAAoACwFUTE9LV0NMOTVSVTAzRDlQRVRHAAI3M0dWVERYREVHRTI3TTJYSk1UAAMBBAEAAiMwMDAwMDAAA8gBAAUBAQIjMDAwMDAwAAPIAQAAAAIDAA%3D%3D" xsd:string {name="Reference data on Allen Brain Cell Atlas"} property_value: seeAlso "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_30.h5ad" xsd:string {comment="Warning large data file!", name="h5ad data file for CS20230722_CLAS_30"} [Term] id: CL:4307084 name: CHOR NN_1 Tbc1d1 choroid plexus epithelial cell (Mmus) def: "A choroid plexus epithelial cell of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of 2900040C04Rik (Mmus), Tbc1d1 (Mmus). It is distinguished from other CHOR NN cells by expression of Tbc1d1. These cells are located in the Cerebellum, brain , in or close to the regions: Paraflocculus, choroid plexus . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5264 CHOR NN_1." [https://doi.org/10.1038/s41586-023-06812-z] comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions. subset: human_subset subset: mouse_subset synonym: "5264 CHOR NN_1" EXACT [] is_a: CL:4301608 ! choroid plexus epithelial cell (Mmus) property_value: CLM:0010001 MBA:1041 {CLM:0010002="0.1", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF acronym region."} property_value: CLM:0010001 MBA:108 {CLM:0010002="0.49", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF acronym region."} property_value: CLM:0010001 MBA:512 {CLM:0010002="0.24", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF broad region."} property_value: CLM:0010001 MBA:997 {CLM:0010002="0.74", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF broad region."} property_value: CLM:0010003 CLM:5007014 {STATO:0000663="0.6818182"} property_value: CLM:0010003 CLM:5022234 {STATO:0000663="0.9405941"} property_value: IAO:0000028 "CHOR NN_1 Tbc1d1 (Mmus)" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIAAAFDQkdDMFUzMFZWOUpQUjYwVEpVAAIBNTI2NCBDSE9SIE5OXzEAAAQBAQKBrMaOgZYVIAOEak39hFgYTQAFAAYBAQJDQkdDMFUzMFZWOUpQUjYwVEpVAAN%2BAAAABAAACEc0STRHRkpYSkI5QVRaM1BUWDEACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAW5vbmUAAm5vbmUAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAUs5Sk4yM1AyNEtRQ0dLOVU3NUEAAkhTWVpQWlcxNjY5VTgyMUJXWVAAAwQBRlMwMERYVjBUOVIxWDlGSjRRRQACAAABUVk1UzhLTU81SExKVUYwUDAwSwACAAABMTVCSzQ3RENJT0YxU0xMVVc5UAACAAABQ0JHQzBVMzBWVjlKUFI2MFRKVQACATUyNjQgQ0hPUiBOTl8xAAAEAQAChFC%2FH4OCCX8DhKAah4TEPdkEMk5RVElFN1RBTVA4UFFBSE80UAAFga%2BmSoHprA6BoIFHgJLV6AYABwAABQAGAQECQ0JHQzBVMzBWVjlKUFI2MFRKVQADfgAAAAQAAAhWRk9GWVBGUUdSS1VEUVVaM0ZGAAlMVkRCSkFXOEJJNVlTUzFRVUJHAAoACwFUTE9LV0NMOTVSVTAzRDlQRVRHAAI3M0dWVERYREVHRTI3TTJYSk1UAAMBBAEAAiMwMDAwMDAAA8gBAAUBAQIjMDAwMDAwAAPIAQAAAAIDAA%3D%3D" xsd:string {name="Reference data on Allen Brain Cell Atlas"} property_value: seeAlso "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_30.h5ad" xsd:string {comment="Warning large data file!", name="h5ad data file for CS20230722_CLAS_30"} [Term] id: CL:4307085 name: CHOR NN_1 Slc17a8 choroid plexus epithelial cell (Mmus) def: "A choroid plexus epithelial cell of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of 2900040C04Rik (Mmus), Slc17a8 (Mmus). It is distinguished from other CHOR NN cells by expression of Slc17a8. It is glutamatergic (inferred from expression of Slc17a8). These cells are located in the brain , in or close to the regions: choroid plexus, lateral ventricle . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5265 CHOR NN_1." [https://doi.org/10.1038/s41586-023-06812-z] comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions. subset: human_subset subset: mouse_subset synonym: "5265 CHOR NN_1" EXACT [] is_a: CL:0000686 ! cerebrospinal fluid secreting cell is_a: CL:4301608 ! choroid plexus epithelial cell (Mmus) relationship: RO:0002215 GO:0061535 {comment="Inferred to be glutamate secretion, neurotransmission based on expression of Slc17a8"} ! capable of glutamate secretion, neurotransmission property_value: CLM:0010001 MBA:108 {CLM:0010002="0.18", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF acronym region."} property_value: CLM:0010001 MBA:81 {CLM:0010002="0.22", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF acronym region."} property_value: CLM:0010001 MBA:997 {CLM:0010002="0.81", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF broad region."} property_value: CLM:0010003 CLM:5007015 {STATO:0000663="0.8227848"} property_value: CLM:0010003 CLM:5022235 {STATO:0000663="0.86206895"} property_value: IAO:0000028 "CHOR NN_1 Slc17a8 (Mmus)" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIAAAFDQkdDMFUzMFZWOUpQUjYwVEpVAAIBNTI2NSBDSE9SIE5OXzEAAAQBAQKBrMaOgZYVIAOEak39hFgYTQAFAAYBAQJDQkdDMFUzMFZWOUpQUjYwVEpVAAN%2BAAAABAAACEc0STRHRkpYSkI5QVRaM1BUWDEACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAW5vbmUAAm5vbmUAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAUs5Sk4yM1AyNEtRQ0dLOVU3NUEAAkhTWVpQWlcxNjY5VTgyMUJXWVAAAwQBRlMwMERYVjBUOVIxWDlGSjRRRQACAAABUVk1UzhLTU81SExKVUYwUDAwSwACAAABMTVCSzQ3RENJT0YxU0xMVVc5UAACAAABQ0JHQzBVMzBWVjlKUFI2MFRKVQACATUyNjUgQ0hPUiBOTl8xAAAEAQAChFC%2FH4OCCX8DhKAah4TEPdkEMk5RVElFN1RBTVA4UFFBSE80UAAFga%2BmSoHprA6BoIFHgJLV6AYABwAABQAGAQECQ0JHQzBVMzBWVjlKUFI2MFRKVQADfgAAAAQAAAhWRk9GWVBGUUdSS1VEUVVaM0ZGAAlMVkRCSkFXOEJJNVlTUzFRVUJHAAoACwFUTE9LV0NMOTVSVTAzRDlQRVRHAAI3M0dWVERYREVHRTI3TTJYSk1UAAMBBAEAAiMwMDAwMDAAA8gBAAUBAQIjMDAwMDAwAAPIAQAAAAIDAA%3D%3D" xsd:string {name="Reference data on Allen Brain Cell Atlas"} property_value: seeAlso "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_30.h5ad" xsd:string {comment="Warning large data file!", name="h5ad data file for CS20230722_CLAS_30"} [Term] id: CL:4307086 name: OPC NN_1 Neil3 oligodendrocyte precursor cell (Mmus) def: "A oligodendrocyte precursor cell of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Pdgfra (Mmus), Pclaf (Mmus), Mki67 (Mmus), Foxg1 (Mmus). It is distinguished from other OPC NN_1 cells by expression of Neil3, Foxg1. These cells are located in the Isocortex, brain . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5266 OPC NN_1." [https://doi.org/10.1038/s41586-023-06812-z] comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions. subset: mouse_subset synonym: "5266 OPC NN_1" EXACT [] is_a: CL:4300366 ! oligodendrocyte precursor cell (Mmus) property_value: CLM:0010001 MBA:315 {CLM:0010002="0.52", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF broad region."} property_value: CLM:0010001 MBA:997 {CLM:0010002="0.14", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF broad region."} property_value: CLM:0010003 CLM:5007016 {STATO:0000663="0.40697673"} property_value: CLM:0010003 CLM:5022236 {STATO:0000663="0.40816328"} property_value: IAO:0000028 "OPC NN_1 Neil3 (Mmus)" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#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%2BDggl%2FA4SgGoeExD3ZBDJOUVRJRTdUQU1QOFBRQUhPNFAABYGvpkqB6awOgaCBR4CS1egGAAcAAAUABgEBAkNCR0MwVTMwVlY5SlBSNjBUSlUAA34AAAAEAAAIVkZPRllQRlFHUktVRFFVWjNGRgAJTFZEQkpBVzhCSTVZU1MxUVVCRwAKAAsBVExPS1dDTDk1UlUwM0Q5UEVURwACNzNHVlREWERFR0UyN00yWEpNVAADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAACAwA%3D" xsd:string {name="Reference data on Allen Brain Cell Atlas"} property_value: seeAlso "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_31.h5ad" xsd:string {comment="Warning large data file!", name="h5ad data file for CS20230722_CLAS_31"} [Term] id: CL:4307087 name: OPC NN_1 Irx2 oligodendrocyte precursor cell (Mmus) def: "A oligodendrocyte precursor cell of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Pdgfra (Mmus), Pclaf (Mmus), Irx2 (Mmus). It is distinguished from other OPC NN_1 cells by expression of Neil3, Irx2. These cells are located in the Cerebellum, brain, Midbrain, Pons, Medulla . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5267 OPC NN_1." [https://doi.org/10.1038/s41586-023-06812-z] comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions. subset: mouse_subset synonym: "5267 OPC NN_1" EXACT [] is_a: CL:4300366 ! oligodendrocyte precursor cell (Mmus) property_value: CLM:0010001 MBA:313 {CLM:0010002="0.21", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF broad region."} property_value: CLM:0010001 MBA:354 {CLM:0010002="0.13", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF broad region."} property_value: CLM:0010001 MBA:512 {CLM:0010002="0.14", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF broad region."} property_value: CLM:0010001 MBA:771 {CLM:0010002="0.17", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF broad region."} property_value: CLM:0010001 MBA:997 {CLM:0010002="0.23", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF broad region."} property_value: CLM:0010003 CLM:5007017 {STATO:0000663="0.7246377"} property_value: CLM:0010003 CLM:5022237 {STATO:0000663="0.6557377"} property_value: IAO:0000028 "OPC NN_1 Irx2 (Mmus)" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#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%2BDggl%2FA4SgGoeExD3ZBDJOUVRJRTdUQU1QOFBRQUhPNFAABYGvpkqB6awOgaCBR4CS1egGAAcAAAUABgEBAkNCR0MwVTMwVlY5SlBSNjBUSlUAA34AAAAEAAAIVkZPRllQRlFHUktVRFFVWjNGRgAJTFZEQkpBVzhCSTVZU1MxUVVCRwAKAAsBVExPS1dDTDk1UlUwM0Q5UEVURwACNzNHVlREWERFR0UyN00yWEpNVAADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAACAwA%3D" xsd:string {name="Reference data on Allen Brain Cell Atlas"} property_value: seeAlso "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_31.h5ad" xsd:string {comment="Warning large data file!", name="h5ad data file for CS20230722_CLAS_31"} [Term] id: CL:4307088 name: OPC NN_1 Mms22l oligodendrocyte precursor cell (Mmus) def: "A oligodendrocyte precursor cell of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Pdgfra (Mmus), Olig1 (Mmus), Mms22l (Mmus), Top2a (Mmus). It is distinguished from other OPC NN_1 cells by expression of Mms22l, Foxg1, Top2a. These cells are located in the Isocortex, Olfactory areas, brain . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5268 OPC NN_1." [https://doi.org/10.1038/s41586-023-06812-z] comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions. subset: mouse_subset synonym: "5268 OPC NN_1" EXACT [] is_a: CL:4300366 ! oligodendrocyte precursor cell (Mmus) property_value: CLM:0010001 MBA:315 {CLM:0010002="0.53", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF broad region."} property_value: CLM:0010001 MBA:698 {CLM:0010002="0.12", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF broad region."} property_value: CLM:0010001 MBA:997 {CLM:0010002="0.1", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF broad region."} property_value: CLM:0010003 CLM:5007018 {STATO:0000663="0.18518518"} property_value: CLM:0010003 CLM:5022238 {STATO:0000663="0.18656716"} property_value: IAO:0000028 "OPC NN_1 Mms22l (Mmus)" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIAAAFDQkdDMFUzMFZWOUpQUjYwVEpVAAIBNTI2OCBPUEMgTk5fMQAABAEBAoGsxo6BlhUgA4RqTf2EWBhNAAUABgEBAkNCR0MwVTMwVlY5SlBSNjBUSlUAA34AAAAEAAAIRzRJNEdGSlhKQjlBVFozUFRYMQAJTFZEQkpBVzhCSTVZU1MxUVVCRwAKAAsBbm9uZQACbm9uZQADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAABSzlKTjIzUDI0S1FDR0s5VTc1QQACSFNZWlBaVzE2NjlVODIxQldZUAADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIAAAFDQkdDMFUzMFZWOUpQUjYwVEpVAAIBNTI2OCBPUEMgTk5fMQAABAEAAoRQvx%2BDggl%2FA4SgGoeExD3ZBDJOUVRJRTdUQU1QOFBRQUhPNFAABYGvpkqB6awOgaCBR4CS1egGAAcAAAUABgEBAkNCR0MwVTMwVlY5SlBSNjBUSlUAA34AAAAEAAAIVkZPRllQRlFHUktVRFFVWjNGRgAJTFZEQkpBVzhCSTVZU1MxUVVCRwAKAAsBVExPS1dDTDk1UlUwM0Q5UEVURwACNzNHVlREWERFR0UyN00yWEpNVAADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAACAwA%3D" xsd:string {name="Reference data on Allen Brain Cell Atlas"} property_value: seeAlso "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_31.h5ad" xsd:string {comment="Warning large data file!", name="h5ad data file for CS20230722_CLAS_31"} [Term] id: CL:4307089 name: OPC NN_1 Col27a1 oligodendrocyte precursor cell (Mmus) def: "A oligodendrocyte precursor cell of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Pdgfra (Mmus), Olig1 (Mmus), Col27a1 (Mmus). It is distinguished from other OPC NN_1 cells by expression of Col27a1. These cells are located in the Midbrain, Pons, brain . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5269 OPC NN_1." [https://doi.org/10.1038/s41586-023-06812-z] comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions. subset: mouse_subset synonym: "5269 OPC NN_1" EXACT [] is_a: CL:4300366 ! oligodendrocyte precursor cell (Mmus) property_value: CLM:0010001 MBA:313 {CLM:0010002="0.17", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF broad region."} property_value: CLM:0010001 MBA:771 {CLM:0010002="0.11", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF broad region."} property_value: CLM:0010001 MBA:997 {CLM:0010002="0.16", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF broad region."} property_value: CLM:0010003 CLM:5007019 {STATO:0000663="0.38235295"} property_value: CLM:0010003 CLM:5022239 {STATO:0000663="0.41366908"} property_value: IAO:0000028 "OPC NN_1 Col27a1 (Mmus)" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#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%2BDggl%2FA4SgGoeExD3ZBDJOUVRJRTdUQU1QOFBRQUhPNFAABYGvpkqB6awOgaCBR4CS1egGAAcAAAUABgEBAkNCR0MwVTMwVlY5SlBSNjBUSlUAA34AAAAEAAAIVkZPRllQRlFHUktVRFFVWjNGRgAJTFZEQkpBVzhCSTVZU1MxUVVCRwAKAAsBVExPS1dDTDk1UlUwM0Q5UEVURwACNzNHVlREWERFR0UyN00yWEpNVAADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAACAwA%3D" xsd:string {name="Reference data on Allen Brain Cell Atlas"} property_value: seeAlso "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_31.h5ad" xsd:string {comment="Warning large data file!", name="h5ad data file for CS20230722_CLAS_31"} [Term] id: CL:4307090 name: OPC NN_1 Rmi2 oligodendrocyte precursor cell (Mmus) def: "A oligodendrocyte precursor cell of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Pdgfra (Mmus), Olig1 (Mmus), Rmi2 (Mmus), Col27a1 (Mmus). It is distinguished from other OPC NN_1 cells by expression of Rmi2, Col27a1. These cells are located in the Hypothalamus, Midbrain, Pallidum, brain . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5270 OPC NN_1." [https://doi.org/10.1038/s41586-023-06812-z] comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions. subset: mouse_subset synonym: "5270 OPC NN_1" EXACT [] is_a: CL:4300366 ! oligodendrocyte precursor cell (Mmus) property_value: CLM:0010001 MBA:1097 {CLM:0010002="0.17", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF broad region."} property_value: CLM:0010001 MBA:313 {CLM:0010002="0.39", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF broad region."} property_value: CLM:0010001 MBA:803 {CLM:0010002="0.1", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF broad region."} property_value: CLM:0010001 MBA:997 {CLM:0010002="0.1", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF broad region."} property_value: CLM:0010003 CLM:5007020 {STATO:0000663="0.0"} property_value: CLM:0010003 CLM:5022240 {STATO:0000663="0.37190083"} property_value: IAO:0000028 "OPC NN_1 Rmi2 (Mmus)" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#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%2BDggl%2FA4SgGoeExD3ZBDJOUVRJRTdUQU1QOFBRQUhPNFAABYGvpkqB6awOgaCBR4CS1egGAAcAAAUABgEBAkNCR0MwVTMwVlY5SlBSNjBUSlUAA34AAAAEAAAIVkZPRllQRlFHUktVRFFVWjNGRgAJTFZEQkpBVzhCSTVZU1MxUVVCRwAKAAsBVExPS1dDTDk1UlUwM0Q5UEVURwACNzNHVlREWERFR0UyN00yWEpNVAADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAACAwA%3D" xsd:string {name="Reference data on Allen Brain Cell Atlas"} property_value: seeAlso "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_31.h5ad" xsd:string {comment="Warning large data file!", name="h5ad data file for CS20230722_CLAS_31"} [Term] id: CL:4307091 name: OPC NN_2 oligodendrocyte precursor cell (Mmus) def: "A oligodendrocyte precursor cell of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Pdgfra (Mmus), Cenpf (Mmus), Cenpa (Mmus). It is distinguished from other OPC NN cells by expression of Cenpa. These cells are located in the Isocortex, brain . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5271 OPC NN_2." [https://doi.org/10.1038/s41586-023-06812-z] comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions. subset: mouse_subset synonym: "1180 OPC NN_2" EXACT [] synonym: "5271 OPC NN_2" EXACT [] is_a: CL:4300366 ! oligodendrocyte precursor cell (Mmus) property_value: CLM:0010001 MBA:315 {CLM:0010002="0.26", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF broad region."} property_value: CLM:0010001 MBA:997 {CLM:0010002="0.17", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF broad region."} property_value: CLM:0010003 CLM:5007021 {STATO:0000663="0.6372549"} property_value: CLM:0010003 CLM:5022241 {STATO:0000663="0.92105263"} property_value: IAO:0000028 "OPC NN_2 (Mmus)" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#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%2BDggl%2FA4SgGoeExD3ZBDJOUVRJRTdUQU1QOFBRQUhPNFAABYGvpkqB6awOgaCBR4CS1egGAAcAAAUABgEBAkNCR0MwVTMwVlY5SlBSNjBUSlUAA34AAAAEAAAIVkZPRllQRlFHUktVRFFVWjNGRgAJTFZEQkpBVzhCSTVZU1MxUVVCRwAKAAsBVExPS1dDTDk1UlUwM0Q5UEVURwACNzNHVlREWERFR0UyN00yWEpNVAADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAACAwA%3D" xsd:string {name="Reference data on Allen Brain Cell Atlas"} property_value: seeAlso "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_31.h5ad" xsd:string {comment="Warning large data file!", name="h5ad data file for CS20230722_CLAS_31"} [Term] id: CL:4307092 name: COP NN_1 Rgcc committed oligodendrocyte precursor (Mmus) def: "A committed oligodendrocyte precursor of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Gpr17 (Mmus), Bmp4 (Mmus), Zfp36l1 (Mmus). It is distinguished from other COP NN_1 cells by expression of Rgcc, Plpp4. These cells are located in the Isocortex, brain . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5272 COP NN_1." [https://doi.org/10.1038/s41586-023-06812-z] comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions. subset: mouse_subset synonym: "5272 COP NN_1" EXACT [] is_a: CL:4301611 ! commited oligodendrocyte precursor (Mmus) property_value: CLM:0010001 MBA:315 {CLM:0010002="0.22", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF broad region."} property_value: CLM:0010001 MBA:997 {CLM:0010002="0.2", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF broad region."} property_value: CLM:0010003 CLM:5007022 {STATO:0000663="0.3888889"} property_value: CLM:0010003 CLM:5022242 {STATO:0000663="0.54347825"} property_value: IAO:0000028 "COP NN_1 Rgcc (Mmus)" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#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%2BDggl%2FA4SgGoeExD3ZBDJOUVRJRTdUQU1QOFBRQUhPNFAABYGvpkqB6awOgaCBR4CS1egGAAcAAAUABgEBAkNCR0MwVTMwVlY5SlBSNjBUSlUAA34AAAAEAAAIVkZPRllQRlFHUktVRFFVWjNGRgAJTFZEQkpBVzhCSTVZU1MxUVVCRwAKAAsBVExPS1dDTDk1UlUwM0Q5UEVURwACNzNHVlREWERFR0UyN00yWEpNVAADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAACAwA%3D" xsd:string {name="Reference data on Allen Brain Cell Atlas"} property_value: seeAlso "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_31.h5ad" xsd:string {comment="Warning large data file!", name="h5ad data file for CS20230722_CLAS_31"} [Term] id: CL:4307093 name: COP NN_1 9130019P16Rik committed oligodendrocyte precursor (Mmus) def: "A committed oligodendrocyte precursor of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Gpr17 (Mmus), Gp1bb (Mmus), Pdzd2 (Mmus), Plekhg1 (Mmus). It is distinguished from other COP NN_1 cells by expression of Rgcc, 9130019P16Rik. These cells are located in the Isocortex, brain . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5273 COP NN_1." [https://doi.org/10.1038/s41586-023-06812-z] comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions. subset: mouse_subset synonym: "5273 COP NN_1" EXACT [] is_a: CL:4301611 ! commited oligodendrocyte precursor (Mmus) property_value: CLM:0010001 MBA:315 {CLM:0010002="0.33", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF broad region."} property_value: CLM:0010001 MBA:997 {CLM:0010002="0.2", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF broad region."} property_value: CLM:0010003 CLM:5007023 {STATO:0000663="0.08064516"} property_value: CLM:0010003 CLM:5022243 {STATO:0000663="0.48245615"} property_value: IAO:0000028 "COP NN_1 9130019P16Rik (Mmus)" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#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%2BDggl%2FA4SgGoeExD3ZBDJOUVRJRTdUQU1QOFBRQUhPNFAABYGvpkqB6awOgaCBR4CS1egGAAcAAAUABgEBAkNCR0MwVTMwVlY5SlBSNjBUSlUAA34AAAAEAAAIVkZPRllQRlFHUktVRFFVWjNGRgAJTFZEQkpBVzhCSTVZU1MxUVVCRwAKAAsBVExPS1dDTDk1UlUwM0Q5UEVURwACNzNHVlREWERFR0UyN00yWEpNVAADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAACAwA%3D" xsd:string {name="Reference data on Allen Brain Cell Atlas"} property_value: seeAlso "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_31.h5ad" xsd:string {comment="Warning large data file!", name="h5ad data file for CS20230722_CLAS_31"} [Term] id: CL:4307094 name: COP NN_1 C1ql1 committed oligodendrocyte precursor (Mmus) def: "A committed oligodendrocyte precursor of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Gpr17 (Mmus), Bgn (Mmus), Gstp1 (Mmus), C1ql1 (Mmus). It is distinguished from other COP NN_1 cells by expression of C1ql1, Gstp1. These cells are located in the brain . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5274 COP NN_1." [https://doi.org/10.1038/s41586-023-06812-z] comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions. subset: mouse_subset synonym: "5274 COP NN_1" EXACT [] is_a: CL:4301611 ! commited oligodendrocyte precursor (Mmus) property_value: CLM:0010001 MBA:997 {CLM:0010002="0.41", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF broad region."} property_value: CLM:0010003 CLM:5007024 {STATO:0000663="0.0"} property_value: CLM:0010003 CLM:5022244 {STATO:0000663="0.1724138"} property_value: IAO:0000028 "COP NN_1 C1ql1 (Mmus)" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#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%2BDggl%2FA4SgGoeExD3ZBDJOUVRJRTdUQU1QOFBRQUhPNFAABYGvpkqB6awOgaCBR4CS1egGAAcAAAUABgEBAkNCR0MwVTMwVlY5SlBSNjBUSlUAA34AAAAEAAAIVkZPRllQRlFHUktVRFFVWjNGRgAJTFZEQkpBVzhCSTVZU1MxUVVCRwAKAAsBVExPS1dDTDk1UlUwM0Q5UEVURwACNzNHVlREWERFR0UyN00yWEpNVAADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAACAwA%3D" xsd:string {name="Reference data on Allen Brain Cell Atlas"} property_value: seeAlso "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_31.h5ad" xsd:string {comment="Warning large data file!", name="h5ad data file for CS20230722_CLAS_31"} [Term] id: CL:4307095 name: COP NN_1 Bmp4 committed oligodendrocyte precursor (Mmus) def: "A committed oligodendrocyte precursor of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of 9630013A20Rik (Mmus), Bmp4 (Mmus), Mob3b (Mmus). It is distinguished from other COP NN_1 cells by expression of Bmp4, Mob3b. These cells are located in the brain . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5275 COP NN_1." [https://doi.org/10.1038/s41586-023-06812-z] comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions. subset: mouse_subset synonym: "5275 COP NN_1" EXACT [] is_a: CL:4301611 ! commited oligodendrocyte precursor (Mmus) property_value: CLM:0010001 MBA:997 {CLM:0010002="0.37", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF broad region."} property_value: CLM:0010003 CLM:5007025 {STATO:0000663="0.3539823"} property_value: CLM:0010003 CLM:5022245 {STATO:0000663="0.35135135"} property_value: IAO:0000028 "COP NN_1 Bmp4 (Mmus)" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#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%2BDggl%2FA4SgGoeExD3ZBDJOUVRJRTdUQU1QOFBRQUhPNFAABYGvpkqB6awOgaCBR4CS1egGAAcAAAUABgEBAkNCR0MwVTMwVlY5SlBSNjBUSlUAA34AAAAEAAAIVkZPRllQRlFHUktVRFFVWjNGRgAJTFZEQkpBVzhCSTVZU1MxUVVCRwAKAAsBVExPS1dDTDk1UlUwM0Q5UEVURwACNzNHVlREWERFR0UyN00yWEpNVAADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAACAwA%3D" xsd:string {name="Reference data on Allen Brain Cell Atlas"} property_value: seeAlso "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_31.h5ad" xsd:string {comment="Warning large data file!", name="h5ad data file for CS20230722_CLAS_31"} [Term] id: CL:4307096 name: COP NN_1 Vwc2 committed oligodendrocyte precursor (Mmus) def: "A committed oligodendrocyte precursor of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of 9630013A20Rik (Mmus), Rab32 (Mmus), Opalin (Mmus). It is distinguished from other COP NN_1 cells by expression of Vwc2, Opalin. These cells are located in the brain . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5276 COP NN_1." [https://doi.org/10.1038/s41586-023-06812-z] comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions. subset: mouse_subset synonym: "5276 COP NN_1" EXACT [] is_a: CL:4301611 ! commited oligodendrocyte precursor (Mmus) property_value: CLM:0010001 MBA:997 {CLM:0010002="0.51", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF broad region."} property_value: CLM:0010003 CLM:5007026 {STATO:0000663="0.31914893"} property_value: CLM:0010003 CLM:5022246 {STATO:0000663="0.0"} property_value: IAO:0000028 "COP NN_1 Vwc2 (Mmus)" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#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%2BDggl%2FA4SgGoeExD3ZBDJOUVRJRTdUQU1QOFBRQUhPNFAABYGvpkqB6awOgaCBR4CS1egGAAcAAAUABgEBAkNCR0MwVTMwVlY5SlBSNjBUSlUAA34AAAAEAAAIVkZPRllQRlFHUktVRFFVWjNGRgAJTFZEQkpBVzhCSTVZU1MxUVVCRwAKAAsBVExPS1dDTDk1UlUwM0Q5UEVURwACNzNHVlREWERFR0UyN00yWEpNVAADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAACAwA%3D" xsd:string {name="Reference data on Allen Brain Cell Atlas"} property_value: seeAlso "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_31.h5ad" xsd:string {comment="Warning large data file!", name="h5ad data file for CS20230722_CLAS_31"} [Term] id: CL:4307097 name: COP NN_1 Cck committed oligodendrocyte precursor (Mmus) def: "A committed oligodendrocyte precursor of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of 9630013A20Rik (Mmus), Bmp4 (Mmus), Cck (Mmus), Ptger1 (Mmus). It is distinguished from other COP NN_1 cells by expression of Bmp4, Cck, Ptger1. These cells are located in the Isocortex, Olfactory areas, brain . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5277 COP NN_1." [https://doi.org/10.1038/s41586-023-06812-z] comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions. subset: mouse_subset synonym: "5277 COP NN_1" EXACT [] is_a: CL:4301611 ! commited oligodendrocyte precursor (Mmus) property_value: CLM:0010001 MBA:315 {CLM:0010002="0.54", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF broad region."} property_value: CLM:0010001 MBA:698 {CLM:0010002="0.11", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF broad region."} property_value: CLM:0010001 MBA:997 {CLM:0010002="0.1", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF broad region."} property_value: CLM:0010003 CLM:5007027 {STATO:0000663="0.22727273"} property_value: CLM:0010003 CLM:5022247 {STATO:0000663="0.27027026"} property_value: IAO:0000028 "COP NN_1 Cck (Mmus)" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#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%2BDggl%2FA4SgGoeExD3ZBDJOUVRJRTdUQU1QOFBRQUhPNFAABYGvpkqB6awOgaCBR4CS1egGAAcAAAUABgEBAkNCR0MwVTMwVlY5SlBSNjBUSlUAA34AAAAEAAAIVkZPRllQRlFHUktVRFFVWjNGRgAJTFZEQkpBVzhCSTVZU1MxUVVCRwAKAAsBVExPS1dDTDk1UlUwM0Q5UEVURwACNzNHVlREWERFR0UyN00yWEpNVAADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAACAwA%3D" xsd:string {name="Reference data on Allen Brain Cell Atlas"} property_value: seeAlso "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_31.h5ad" xsd:string {comment="Warning large data file!", name="h5ad data file for CS20230722_CLAS_31"} [Term] id: CL:4307098 name: NFOL NN_2 9630013A20Rik newly formed oligodendrocyte (Mmus) def: "A newly formed oligodendrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of 9630013A20Rik (Mmus), Grin2b (Mmus). It is distinguished from other NFOL NN_2 cells by expression of 9630013A20Rik, Grin2b. These cells are located in the Midbrain, Thalamus, brain . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5278 NFOL NN_2." [https://doi.org/10.1038/s41586-023-06812-z] comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions. subset: mouse_subset synonym: "5278 NFOL NN_2" EXACT [] is_a: CL:4301612 ! newly formed oligodendrocyte (Mmus) property_value: CLM:0010001 MBA:313 {CLM:0010002="0.31", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF broad region."} property_value: CLM:0010001 MBA:549 {CLM:0010002="0.1", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF broad region."} property_value: CLM:0010001 MBA:997 {CLM:0010002="0.12", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF broad region."} property_value: CLM:0010003 CLM:5007028 {STATO:0000663="0.17482518"} property_value: CLM:0010003 CLM:5022248 {STATO:0000663="0.29801324"} property_value: IAO:0000028 "NFOL NN_2 9630013A20Rik (Mmus)" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIAAAFDQkdDMFUzMFZWOUpQUjYwVEpVAAIBNTI3OCBORk9MIE5OXzIAAAQBAQKBrMaOgZYVIAOEak39hFgYTQAFAAYBAQJDQkdDMFUzMFZWOUpQUjYwVEpVAAN%2BAAAABAAACEc0STRHRkpYSkI5QVRaM1BUWDEACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAW5vbmUAAm5vbmUAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAUs5Sk4yM1AyNEtRQ0dLOVU3NUEAAkhTWVpQWlcxNjY5VTgyMUJXWVAAAwQBRlMwMERYVjBUOVIxWDlGSjRRRQACAAABUVk1UzhLTU81SExKVUYwUDAwSwACAAABMTVCSzQ3RENJT0YxU0xMVVc5UAACAAABQ0JHQzBVMzBWVjlKUFI2MFRKVQACATUyNzggTkZPTCBOTl8yAAAEAQAChFC%2FH4OCCX8DhKAah4TEPdkEMk5RVElFN1RBTVA4UFFBSE80UAAFga%2BmSoHprA6BoIFHgJLV6AYABwAABQAGAQECQ0JHQzBVMzBWVjlKUFI2MFRKVQADfgAAAAQAAAhWRk9GWVBGUUdSS1VEUVVaM0ZGAAlMVkRCSkFXOEJJNVlTUzFRVUJHAAoACwFUTE9LV0NMOTVSVTAzRDlQRVRHAAI3M0dWVERYREVHRTI3TTJYSk1UAAMBBAEAAiMwMDAwMDAAA8gBAAUBAQIjMDAwMDAwAAPIAQAAAAIDAA%3D%3D" xsd:string {name="Reference data on Allen Brain Cell Atlas"} property_value: seeAlso "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_31.h5ad" xsd:string {comment="Warning large data file!", name="h5ad data file for CS20230722_CLAS_31"} [Term] id: CL:4307099 name: NFOL NN_2 Dbx2 newly formed oligodendrocyte (Mmus) def: "A newly formed oligodendrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of 9630013A20Rik (Mmus), Dbx2 (Mmus), Rassf10 (Mmus). It is distinguished from other NFOL NN_2 cells by expression of Dbx2, Rassf10. These cells are located in the Isocortex, brain . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5279 NFOL NN_2." [https://doi.org/10.1038/s41586-023-06812-z] comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions. subset: mouse_subset synonym: "5279 NFOL NN_2" EXACT [] is_a: CL:4301612 ! newly formed oligodendrocyte (Mmus) property_value: CLM:0010001 MBA:315 {CLM:0010002="0.24", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF broad region."} property_value: CLM:0010001 MBA:997 {CLM:0010002="0.25", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF broad region."} property_value: CLM:0010003 CLM:5007029 {STATO:0000663="0.5392157"} property_value: CLM:0010003 CLM:5022249 {STATO:0000663="0.7281553"} property_value: IAO:0000028 "NFOL NN_2 Dbx2 (Mmus)" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIAAAFDQkdDMFUzMFZWOUpQUjYwVEpVAAIBNTI3OSBORk9MIE5OXzIAAAQBAQKBrMaOgZYVIAOEak39hFgYTQAFAAYBAQJDQkdDMFUzMFZWOUpQUjYwVEpVAAN%2BAAAABAAACEc0STRHRkpYSkI5QVRaM1BUWDEACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAW5vbmUAAm5vbmUAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAUs5Sk4yM1AyNEtRQ0dLOVU3NUEAAkhTWVpQWlcxNjY5VTgyMUJXWVAAAwQBRlMwMERYVjBUOVIxWDlGSjRRRQACAAABUVk1UzhLTU81SExKVUYwUDAwSwACAAABMTVCSzQ3RENJT0YxU0xMVVc5UAACAAABQ0JHQzBVMzBWVjlKUFI2MFRKVQACATUyNzkgTkZPTCBOTl8yAAAEAQAChFC%2FH4OCCX8DhKAah4TEPdkEMk5RVElFN1RBTVA4UFFBSE80UAAFga%2BmSoHprA6BoIFHgJLV6AYABwAABQAGAQECQ0JHQzBVMzBWVjlKUFI2MFRKVQADfgAAAAQAAAhWRk9GWVBGUUdSS1VEUVVaM0ZGAAlMVkRCSkFXOEJJNVlTUzFRVUJHAAoACwFUTE9LV0NMOTVSVTAzRDlQRVRHAAI3M0dWVERYREVHRTI3TTJYSk1UAAMBBAEAAiMwMDAwMDAAA8gBAAUBAQIjMDAwMDAwAAPIAQAAAAIDAA%3D%3D" xsd:string {name="Reference data on Allen Brain Cell Atlas"} property_value: seeAlso "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_31.h5ad" xsd:string {comment="Warning large data file!", name="h5ad data file for CS20230722_CLAS_31"} [Term] id: CL:4307100 name: NFOL NN_2 Rgs16 newly formed oligodendrocyte (Mmus) def: "A newly formed oligodendrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of 9630013A20Rik (Mmus), Rgs16 (Mmus), Rhbdl2 (Mmus). It is distinguished from other NFOL NN_2 cells by expression of Rgs16, Rhbdl2. These cells are located in the Isocortex, brain . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5280 NFOL NN_2." [https://doi.org/10.1038/s41586-023-06812-z] comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions. subset: mouse_subset synonym: "5280 NFOL NN_2" EXACT [] is_a: CL:4301612 ! newly formed oligodendrocyte (Mmus) property_value: CLM:0010001 MBA:315 {CLM:0010002="0.18", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF broad region."} property_value: CLM:0010001 MBA:997 {CLM:0010002="0.28", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF broad region."} property_value: CLM:0010003 CLM:5007030 {STATO:0000663="0.32051283"} property_value: CLM:0010003 CLM:5022250 {STATO:0000663="0.4878049"} property_value: IAO:0000028 "NFOL NN_2 Rgs16 (Mmus)" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIAAAFDQkdDMFUzMFZWOUpQUjYwVEpVAAIBNTI4MCBORk9MIE5OXzIAAAQBAQKBrMaOgZYVIAOEak39hFgYTQAFAAYBAQJDQkdDMFUzMFZWOUpQUjYwVEpVAAN%2BAAAABAAACEc0STRHRkpYSkI5QVRaM1BUWDEACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAW5vbmUAAm5vbmUAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAUs5Sk4yM1AyNEtRQ0dLOVU3NUEAAkhTWVpQWlcxNjY5VTgyMUJXWVAAAwQBRlMwMERYVjBUOVIxWDlGSjRRRQACAAABUVk1UzhLTU81SExKVUYwUDAwSwACAAABMTVCSzQ3RENJT0YxU0xMVVc5UAACAAABQ0JHQzBVMzBWVjlKUFI2MFRKVQACATUyODAgTkZPTCBOTl8yAAAEAQAChFC%2FH4OCCX8DhKAah4TEPdkEMk5RVElFN1RBTVA4UFFBSE80UAAFga%2BmSoHprA6BoIFHgJLV6AYABwAABQAGAQECQ0JHQzBVMzBWVjlKUFI2MFRKVQADfgAAAAQAAAhWRk9GWVBGUUdSS1VEUVVaM0ZGAAlMVkRCSkFXOEJJNVlTUzFRVUJHAAoACwFUTE9LV0NMOTVSVTAzRDlQRVRHAAI3M0dWVERYREVHRTI3TTJYSk1UAAMBBAEAAiMwMDAwMDAAA8gBAAUBAQIjMDAwMDAwAAPIAQAAAAIDAA%3D%3D" xsd:string {name="Reference data on Allen Brain Cell Atlas"} property_value: seeAlso "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_31.h5ad" xsd:string {comment="Warning large data file!", name="h5ad data file for CS20230722_CLAS_31"} [Term] id: CL:4307101 name: NFOL NN_2 Il23a newly formed oligodendrocyte (Mmus) def: "A newly formed oligodendrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of 9630013A20Rik (Mmus), Piezo2 (Mmus), Ptprb (Mmus). It is distinguished from other NFOL NN_2 cells by expression of Il23a, Opalin, Ptprb. These cells are located in the Isocortex, brain . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5281 NFOL NN_2." [https://doi.org/10.1038/s41586-023-06812-z] comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions. subset: mouse_subset synonym: "5281 NFOL NN_2" EXACT [] is_a: CL:4301612 ! newly formed oligodendrocyte (Mmus) property_value: CLM:0010001 MBA:315 {CLM:0010002="0.19", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF broad region."} property_value: CLM:0010001 MBA:997 {CLM:0010002="0.3", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF broad region."} property_value: CLM:0010003 CLM:5007031 {STATO:0000663="0.35714287"} property_value: CLM:0010003 CLM:5022251 {STATO:0000663="0.7368421"} property_value: IAO:0000028 "NFOL NN_2 Il23a (Mmus)" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIAAAFDQkdDMFUzMFZWOUpQUjYwVEpVAAIBNTI4MSBORk9MIE5OXzIAAAQBAQKBrMaOgZYVIAOEak39hFgYTQAFAAYBAQJDQkdDMFUzMFZWOUpQUjYwVEpVAAN%2BAAAABAAACEc0STRHRkpYSkI5QVRaM1BUWDEACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAW5vbmUAAm5vbmUAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAUs5Sk4yM1AyNEtRQ0dLOVU3NUEAAkhTWVpQWlcxNjY5VTgyMUJXWVAAAwQBRlMwMERYVjBUOVIxWDlGSjRRRQACAAABUVk1UzhLTU81SExKVUYwUDAwSwACAAABMTVCSzQ3RENJT0YxU0xMVVc5UAACAAABQ0JHQzBVMzBWVjlKUFI2MFRKVQACATUyODEgTkZPTCBOTl8yAAAEAQAChFC%2FH4OCCX8DhKAah4TEPdkEMk5RVElFN1RBTVA4UFFBSE80UAAFga%2BmSoHprA6BoIFHgJLV6AYABwAABQAGAQECQ0JHQzBVMzBWVjlKUFI2MFRKVQADfgAAAAQAAAhWRk9GWVBGUUdSS1VEUVVaM0ZGAAlMVkRCSkFXOEJJNVlTUzFRVUJHAAoACwFUTE9LV0NMOTVSVTAzRDlQRVRHAAI3M0dWVERYREVHRTI3TTJYSk1UAAMBBAEAAiMwMDAwMDAAA8gBAAUBAQIjMDAwMDAwAAPIAQAAAAIDAA%3D%3D" xsd:string {name="Reference data on Allen Brain Cell Atlas"} property_value: seeAlso "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_31.h5ad" xsd:string {comment="Warning large data file!", name="h5ad data file for CS20230722_CLAS_31"} [Term] id: CL:4307102 name: MFOL NN_3 Cxcl12 myelin-forming oligodendrocyte (Mmus) def: "A myelin-forming oligodendrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Opalin (Mmus), Cxcl12 (Mmus), Efhd1 (Mmus). It is distinguished from other MFOL NN_3 cells by expression of Cxcl12, Efhd1. These cells are located in the Isocortex, brain . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5282 MFOL NN_3." [https://doi.org/10.1038/s41586-023-06812-z] comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions. subset: mouse_subset synonym: "5282 MFOL NN_3" EXACT [] is_a: CL:4301613 ! myelin-forming oligodendrocyte (Mmus) property_value: CLM:0010001 MBA:315 {CLM:0010002="0.26", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF broad region."} property_value: CLM:0010001 MBA:997 {CLM:0010002="0.26", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF broad region."} property_value: CLM:0010003 CLM:5007032 {STATO:0000663="0.4054054"} property_value: CLM:0010003 CLM:5022252 {STATO:0000663="0.5"} property_value: IAO:0000028 "MFOL NN_3 Cxcl12 (Mmus)" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIAAAFDQkdDMFUzMFZWOUpQUjYwVEpVAAIBNTI4MiBNRk9MIE5OXzMAAAQBAQKBrMaOgZYVIAOEak39hFgYTQAFAAYBAQJDQkdDMFUzMFZWOUpQUjYwVEpVAAN%2BAAAABAAACEc0STRHRkpYSkI5QVRaM1BUWDEACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAW5vbmUAAm5vbmUAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAUs5Sk4yM1AyNEtRQ0dLOVU3NUEAAkhTWVpQWlcxNjY5VTgyMUJXWVAAAwQBRlMwMERYVjBUOVIxWDlGSjRRRQACAAABUVk1UzhLTU81SExKVUYwUDAwSwACAAABMTVCSzQ3RENJT0YxU0xMVVc5UAACAAABQ0JHQzBVMzBWVjlKUFI2MFRKVQACATUyODIgTUZPTCBOTl8zAAAEAQAChFC%2FH4OCCX8DhKAah4TEPdkEMk5RVElFN1RBTVA4UFFBSE80UAAFga%2BmSoHprA6BoIFHgJLV6AYABwAABQAGAQECQ0JHQzBVMzBWVjlKUFI2MFRKVQADfgAAAAQAAAhWRk9GWVBGUUdSS1VEUVVaM0ZGAAlMVkRCSkFXOEJJNVlTUzFRVUJHAAoACwFUTE9LV0NMOTVSVTAzRDlQRVRHAAI3M0dWVERYREVHRTI3TTJYSk1UAAMBBAEAAiMwMDAwMDAAA8gBAAUBAQIjMDAwMDAwAAPIAQAAAAIDAA%3D%3D" xsd:string {name="Reference data on Allen Brain Cell Atlas"} property_value: seeAlso "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_31.h5ad" xsd:string {comment="Warning large data file!", name="h5ad data file for CS20230722_CLAS_31"} [Term] id: CL:4307103 name: MFOL NN_3 Il23a myelin-forming oligodendrocyte (Mmus) def: "A myelin-forming oligodendrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of 9630013A20Rik (Mmus), Ppp1r14a (Mmus), Mroh3 (Mmus). It is distinguished from other MFOL NN_3 cells by expression of Il23a, Ppp1r14a. These cells are located in the Midbrain, Isocortex, brain . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5283 MFOL NN_3." [https://doi.org/10.1038/s41586-023-06812-z] comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions. subset: mouse_subset synonym: "5283 MFOL NN_3" EXACT [] is_a: CL:4301613 ! myelin-forming oligodendrocyte (Mmus) property_value: CLM:0010001 MBA:313 {CLM:0010002="0.1", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF broad region."} property_value: CLM:0010001 MBA:315 {CLM:0010002="0.17", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF broad region."} property_value: CLM:0010001 MBA:997 {CLM:0010002="0.29", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF broad region."} property_value: CLM:0010003 CLM:5007033 {STATO:0000663="0.35714287"} property_value: CLM:0010003 CLM:5022253 {STATO:0000663="0.48387095"} property_value: IAO:0000028 "MFOL NN_3 Il23a (Mmus)" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIAAAFDQkdDMFUzMFZWOUpQUjYwVEpVAAIBNTI4MyBNRk9MIE5OXzMAAAQBAQKBrMaOgZYVIAOEak39hFgYTQAFAAYBAQJDQkdDMFUzMFZWOUpQUjYwVEpVAAN%2BAAAABAAACEc0STRHRkpYSkI5QVRaM1BUWDEACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAW5vbmUAAm5vbmUAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAUs5Sk4yM1AyNEtRQ0dLOVU3NUEAAkhTWVpQWlcxNjY5VTgyMUJXWVAAAwQBRlMwMERYVjBUOVIxWDlGSjRRRQACAAABUVk1UzhLTU81SExKVUYwUDAwSwACAAABMTVCSzQ3RENJT0YxU0xMVVc5UAACAAABQ0JHQzBVMzBWVjlKUFI2MFRKVQACATUyODMgTUZPTCBOTl8zAAAEAQAChFC%2FH4OCCX8DhKAah4TEPdkEMk5RVElFN1RBTVA4UFFBSE80UAAFga%2BmSoHprA6BoIFHgJLV6AYABwAABQAGAQECQ0JHQzBVMzBWVjlKUFI2MFRKVQADfgAAAAQAAAhWRk9GWVBGUUdSS1VEUVVaM0ZGAAlMVkRCSkFXOEJJNVlTUzFRVUJHAAoACwFUTE9LV0NMOTVSVTAzRDlQRVRHAAI3M0dWVERYREVHRTI3TTJYSk1UAAMBBAEAAiMwMDAwMDAAA8gBAAUBAQIjMDAwMDAwAAPIAQAAAAIDAA%3D%3D" xsd:string {name="Reference data on Allen Brain Cell Atlas"} property_value: seeAlso "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_31.h5ad" xsd:string {comment="Warning large data file!", name="h5ad data file for CS20230722_CLAS_31"} [Term] id: CL:4307104 name: MOL NN_4 Plin3 mature myelinating oligodendrocyte (Mmus) def: "A mature myelinating oligodendrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Prr5l (Mmus), Hapln2 (Mmus), Enpp6 (Mmus), Grm7 (Mmus). It is distinguished from other MOL NN_4 cells by expression of Plin3, Grm7. These cells are located in the Medulla, brain . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5284 MOL NN_4." [https://doi.org/10.1038/s41586-023-06812-z] comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions. subset: mouse_subset synonym: "5284 MOL NN_4" EXACT [] is_a: CL:4301614 ! mature myelinating oligodendrocyte (Mmus) property_value: CLM:0010001 MBA:354 {CLM:0010002="0.11", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF broad region."} property_value: CLM:0010001 MBA:997 {CLM:0010002="0.37", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF broad region."} property_value: CLM:0010003 CLM:5007034 {STATO:0000663="0.48507464"} property_value: CLM:0010003 CLM:5022254 {STATO:0000663="0.5"} property_value: IAO:0000028 "MOL NN_4 Plin3 (Mmus)" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#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%2BDggl%2FA4SgGoeExD3ZBDJOUVRJRTdUQU1QOFBRQUhPNFAABYGvpkqB6awOgaCBR4CS1egGAAcAAAUABgEBAkNCR0MwVTMwVlY5SlBSNjBUSlUAA34AAAAEAAAIVkZPRllQRlFHUktVRFFVWjNGRgAJTFZEQkpBVzhCSTVZU1MxUVVCRwAKAAsBVExPS1dDTDk1UlUwM0Q5UEVURwACNzNHVlREWERFR0UyN00yWEpNVAADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAACAwA%3D" xsd:string {name="Reference data on Allen Brain Cell Atlas"} property_value: seeAlso "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_31.h5ad" xsd:string {comment="Warning large data file!", name="h5ad data file for CS20230722_CLAS_31"} [Term] id: CL:4307105 name: MOL NN_4 Spock3 mature myelinating oligodendrocyte (Mmus) def: "A mature myelinating oligodendrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Cldn11 (Mmus), A230001M10Rik (Mmus), Spock3 (Mmus), Rhoj (Mmus). It is distinguished from other MOL NN_4 cells by expression of Spock3, Rhoj. These cells are located in the Midbrain, Isocortex, brain . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5285 MOL NN_4." [https://doi.org/10.1038/s41586-023-06812-z] comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions. subset: mouse_subset synonym: "5285 MOL NN_4" EXACT [] is_a: CL:4301614 ! mature myelinating oligodendrocyte (Mmus) property_value: CLM:0010001 MBA:313 {CLM:0010002="0.14", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF broad region."} property_value: CLM:0010001 MBA:315 {CLM:0010002="0.13", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF broad region."} property_value: CLM:0010001 MBA:997 {CLM:0010002="0.27", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF broad region."} property_value: CLM:0010003 CLM:5007035 {STATO:0000663="0.24193548"} property_value: CLM:0010003 CLM:5022255 {STATO:0000663="0.32786885"} property_value: IAO:0000028 "MOL NN_4 Spock3 (Mmus)" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#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%2BDggl%2FA4SgGoeExD3ZBDJOUVRJRTdUQU1QOFBRQUhPNFAABYGvpkqB6awOgaCBR4CS1egGAAcAAAUABgEBAkNCR0MwVTMwVlY5SlBSNjBUSlUAA34AAAAEAAAIVkZPRllQRlFHUktVRFFVWjNGRgAJTFZEQkpBVzhCSTVZU1MxUVVCRwAKAAsBVExPS1dDTDk1UlUwM0Q5UEVURwACNzNHVlREWERFR0UyN00yWEpNVAADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAACAwA%3D" xsd:string {name="Reference data on Allen Brain Cell Atlas"} property_value: seeAlso "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_31.h5ad" xsd:string {comment="Warning large data file!", name="h5ad data file for CS20230722_CLAS_31"} [Term] id: CL:4307106 name: MOL NN_4 Art3 mature myelinating oligodendrocyte (Mmus) def: "A mature myelinating oligodendrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Apod (Mmus), Klk6 (Mmus), Dlc1 (Mmus). It is distinguished from other MOL NN_4 cells by expression of Art3. These cells are located in the Medulla, Pons, brain . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5286 MOL NN_4." [https://doi.org/10.1038/s41586-023-06812-z] comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions. subset: mouse_subset synonym: "5286 MOL NN_4" EXACT [] is_a: CL:4301614 ! mature myelinating oligodendrocyte (Mmus) property_value: CLM:0010001 MBA:354 {CLM:0010002="0.17", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF broad region."} property_value: CLM:0010001 MBA:771 {CLM:0010002="0.15", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF broad region."} property_value: CLM:0010001 MBA:997 {CLM:0010002="0.44", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF broad region."} property_value: CLM:0010003 CLM:5007036 {STATO:0000663="0.7876712"} property_value: CLM:0010003 CLM:5022256 {STATO:0000663="0.94017094"} property_value: IAO:0000028 "MOL NN_4 Art3 (Mmus)" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#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%2BDggl%2FA4SgGoeExD3ZBDJOUVRJRTdUQU1QOFBRQUhPNFAABYGvpkqB6awOgaCBR4CS1egGAAcAAAUABgEBAkNCR0MwVTMwVlY5SlBSNjBUSlUAA34AAAAEAAAIVkZPRllQRlFHUktVRFFVWjNGRgAJTFZEQkpBVzhCSTVZU1MxUVVCRwAKAAsBVExPS1dDTDk1UlUwM0Q5UEVURwACNzNHVlREWERFR0UyN00yWEpNVAADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAACAwA%3D" xsd:string {name="Reference data on Allen Brain Cell Atlas"} property_value: seeAlso "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_31.h5ad" xsd:string {comment="Warning large data file!", name="h5ad data file for CS20230722_CLAS_31"} [Term] id: CL:4307107 name: MOL NN_4 Il33 mature myelinating oligodendrocyte (Mmus) def: "A mature myelinating oligodendrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Opalin (Mmus), Grm3 (Mmus), Gm5087 (Mmus). It is distinguished from other MOL NN_4 cells by expression of Il33, Gm5087. These cells are located in the Isocortex, brain . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5287 MOL NN_4." [https://doi.org/10.1038/s41586-023-06812-z] comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions. subset: mouse_subset synonym: "5287 MOL NN_4" EXACT [] is_a: CL:4301614 ! mature myelinating oligodendrocyte (Mmus) property_value: CLM:0010001 MBA:315 {CLM:0010002="0.17", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF broad region."} property_value: CLM:0010001 MBA:997 {CLM:0010002="0.41", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF broad region."} property_value: CLM:0010003 CLM:5007037 {STATO:0000663="0.33333334"} property_value: CLM:0010003 CLM:5022257 {STATO:0000663="0.34313726"} property_value: IAO:0000028 "MOL NN_4 Il33 (Mmus)" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#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%2BDggl%2FA4SgGoeExD3ZBDJOUVRJRTdUQU1QOFBRQUhPNFAABYGvpkqB6awOgaCBR4CS1egGAAcAAAUABgEBAkNCR0MwVTMwVlY5SlBSNjBUSlUAA34AAAAEAAAIVkZPRllQRlFHUktVRFFVWjNGRgAJTFZEQkpBVzhCSTVZU1MxUVVCRwAKAAsBVExPS1dDTDk1UlUwM0Q5UEVURwACNzNHVlREWERFR0UyN00yWEpNVAADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAACAwA%3D" xsd:string {name="Reference data on Allen Brain Cell Atlas"} property_value: seeAlso "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_31.h5ad" xsd:string {comment="Warning large data file!", name="h5ad data file for CS20230722_CLAS_31"} [Term] id: CL:4307108 name: MOL NN_4 Sspo mature myelinating oligodendrocyte (Mmus) def: "A mature myelinating oligodendrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Mog (Mmus), Anln (Mmus), Gm32633 (Mmus). It is distinguished from other MOL NN_4 cells by expression of Sspo, Selenop. These cells are located in the Isocortex, brain . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5288 MOL NN_4." [https://doi.org/10.1038/s41586-023-06812-z] comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions. subset: mouse_subset synonym: "5288 MOL NN_4" EXACT [] is_a: CL:4301614 ! mature myelinating oligodendrocyte (Mmus) property_value: CLM:0010001 MBA:315 {CLM:0010002="0.11", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF broad region."} property_value: CLM:0010001 MBA:997 {CLM:0010002="0.41", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF broad region."} property_value: CLM:0010003 CLM:5007038 {STATO:0000663="0.36231884"} property_value: CLM:0010003 CLM:5022258 {STATO:0000663="0.43333334"} property_value: IAO:0000028 "MOL NN_4 Sspo (Mmus)" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#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%2BDggl%2FA4SgGoeExD3ZBDJOUVRJRTdUQU1QOFBRQUhPNFAABYGvpkqB6awOgaCBR4CS1egGAAcAAAUABgEBAkNCR0MwVTMwVlY5SlBSNjBUSlUAA34AAAAEAAAIVkZPRllQRlFHUktVRFFVWjNGRgAJTFZEQkpBVzhCSTVZU1MxUVVCRwAKAAsBVExPS1dDTDk1UlUwM0Q5UEVURwACNzNHVlREWERFR0UyN00yWEpNVAADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAACAwA%3D" xsd:string {name="Reference data on Allen Brain Cell Atlas"} property_value: seeAlso "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_31.h5ad" xsd:string {comment="Warning large data file!", name="h5ad data file for CS20230722_CLAS_31"} [Term] id: CL:4307109 name: OEC NN_1 Adamts12 olfactory ensheathing cell (Mmus) def: "A olfactory ensheathing cell of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Cldn5 (Mmus), Adamts12 (Mmus). It is distinguished from other OEC cells by expression of Adamts12. These cells are located in the brain , in or close to the regions: olfactory nerve layer of main olfactory bulb . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5289 OEC NN_1." [https://doi.org/10.1038/s41586-023-06812-z] comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions. subset: mouse_subset synonym: "5289 OEC NN_1" EXACT [] is_a: CL:4301615 ! olfactory ensheathing cell (Mmus) property_value: CLM:0010001 MBA:1016 {CLM:0010002="0.15", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF acronym region."} property_value: CLM:0010001 MBA:997 {CLM:0010002="0.89", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF broad region."} property_value: CLM:0010003 CLM:5007039 {STATO:0000663="0.71428573"} property_value: CLM:0010003 CLM:5022259 {STATO:0000663="0.7773109"} property_value: IAO:0000028 "OEC NN_1 Adamts12 (Mmus)" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIAAAFDQkdDMFUzMFZWOUpQUjYwVEpVAAIBNTI4OSBPRUMgTk5fMQAABAEBAoGsxo6BlhUgA4RqTf2EWBhNAAUABgEBAkNCR0MwVTMwVlY5SlBSNjBUSlUAA34AAAAEAAAIRzRJNEdGSlhKQjlBVFozUFRYMQAJTFZEQkpBVzhCSTVZU1MxUVVCRwAKAAsBbm9uZQACbm9uZQADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAABSzlKTjIzUDI0S1FDR0s5VTc1QQACSFNZWlBaVzE2NjlVODIxQldZUAADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIAAAFDQkdDMFUzMFZWOUpQUjYwVEpVAAIBNTI4OSBPRUMgTk5fMQAABAEAAoRQvx%2BDggl%2FA4SgGoeExD3ZBDJOUVRJRTdUQU1QOFBRQUhPNFAABYGvpkqB6awOgaCBR4CS1egGAAcAAAUABgEBAkNCR0MwVTMwVlY5SlBSNjBUSlUAA34AAAAEAAAIVkZPRllQRlFHUktVRFFVWjNGRgAJTFZEQkpBVzhCSTVZU1MxUVVCRwAKAAsBVExPS1dDTDk1UlUwM0Q5UEVURwACNzNHVlREWERFR0UyN00yWEpNVAADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAACAwA%3D" xsd:string {name="Reference data on Allen Brain Cell Atlas"} property_value: seeAlso "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_32.h5ad" xsd:string {comment="Warning large data file!", name="h5ad data file for CS20230722_CLAS_32"} [Term] id: CL:4307110 name: OEC NN_1 Gdpd4 olfactory ensheathing cell (Mmus) def: "A olfactory ensheathing cell of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Apod (Mmus), Aqp1 (Mmus), Cldn5 (Mmus). It is distinguished from other OEC cells by expression of Gdpd4, Cldn5. These cells are located in the brain , in or close to the regions: olfactory nerve layer of main olfactory bulb . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5290 OEC NN_1." [https://doi.org/10.1038/s41586-023-06812-z] comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions. subset: mouse_subset synonym: "5290 OEC NN_1" EXACT [] is_a: CL:4301615 ! olfactory ensheathing cell (Mmus) property_value: CLM:0010001 MBA:1016 {CLM:0010002="0.39", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF acronym region."} property_value: CLM:0010001 MBA:997 {CLM:0010002="0.8", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF broad region."} property_value: CLM:0010003 CLM:5007040 {STATO:0000663="0.49019608"} property_value: CLM:0010003 CLM:5022260 {STATO:0000663="0.5479452"} property_value: IAO:0000028 "OEC NN_1 Gdpd4 (Mmus)" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#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%2BDggl%2FA4SgGoeExD3ZBDJOUVRJRTdUQU1QOFBRQUhPNFAABYGvpkqB6awOgaCBR4CS1egGAAcAAAUABgEBAkNCR0MwVTMwVlY5SlBSNjBUSlUAA34AAAAEAAAIVkZPRllQRlFHUktVRFFVWjNGRgAJTFZEQkpBVzhCSTVZU1MxUVVCRwAKAAsBVExPS1dDTDk1UlUwM0Q5UEVURwACNzNHVlREWERFR0UyN00yWEpNVAADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAACAwA%3D" xsd:string {name="Reference data on Allen Brain Cell Atlas"} property_value: seeAlso "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_32.h5ad" xsd:string {comment="Warning large data file!", name="h5ad data file for CS20230722_CLAS_32"} [Term] id: CL:4307111 name: OEC NN_1 A330076C08Rik olfactory ensheathing cell (Mmus) def: "A olfactory ensheathing cell of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Apod (Mmus), Mybpc1 (Mmus), Syk (Mmus). It is distinguished from other OEC cells by expression of A330076C08Rik. These cells are located in the Olfactory areas, brain , in or close to the regions: olfactory nerve layer of main olfactory bulb, Main olfactory bulb . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5291 OEC NN_1." [https://doi.org/10.1038/s41586-023-06812-z] comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions. subset: mouse_subset synonym: "5291 OEC NN_1" EXACT [] is_a: CL:4301615 ! olfactory ensheathing cell (Mmus) property_value: CLM:0010001 MBA:1016 {CLM:0010002="0.14", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF acronym region."} property_value: CLM:0010001 MBA:507 {CLM:0010002="0.16", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF acronym region."} property_value: CLM:0010001 MBA:698 {CLM:0010002="0.36", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF broad region."} property_value: CLM:0010001 MBA:997 {CLM:0010002="0.64", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF broad region."} property_value: CLM:0010003 CLM:5007041 {STATO:0000663="0.44444445"} property_value: CLM:0010003 CLM:5022261 {STATO:0000663="0.77956986"} property_value: IAO:0000028 "OEC NN_1 A330076C08Rik (Mmus)" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIAAAFDQkdDMFUzMFZWOUpQUjYwVEpVAAIBNTI5MSBPRUMgTk5fMQAABAEBAoGsxo6BlhUgA4RqTf2EWBhNAAUABgEBAkNCR0MwVTMwVlY5SlBSNjBUSlUAA34AAAAEAAAIRzRJNEdGSlhKQjlBVFozUFRYMQAJTFZEQkpBVzhCSTVZU1MxUVVCRwAKAAsBbm9uZQACbm9uZQADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAABSzlKTjIzUDI0S1FDR0s5VTc1QQACSFNZWlBaVzE2NjlVODIxQldZUAADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIAAAFDQkdDMFUzMFZWOUpQUjYwVEpVAAIBNTI5MSBPRUMgTk5fMQAABAEAAoRQvx%2BDggl%2FA4SgGoeExD3ZBDJOUVRJRTdUQU1QOFBRQUhPNFAABYGvpkqB6awOgaCBR4CS1egGAAcAAAUABgEBAkNCR0MwVTMwVlY5SlBSNjBUSlUAA34AAAAEAAAIVkZPRllQRlFHUktVRFFVWjNGRgAJTFZEQkpBVzhCSTVZU1MxUVVCRwAKAAsBVExPS1dDTDk1UlUwM0Q5UEVURwACNzNHVlREWERFR0UyN00yWEpNVAADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAACAwA%3D" xsd:string {name="Reference data on Allen Brain Cell Atlas"} property_value: seeAlso "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_32.h5ad" xsd:string {comment="Warning large data file!", name="h5ad data file for CS20230722_CLAS_32"} [Term] id: CL:4307112 name: OEC NN_1 Rasgef1c olfactory ensheathing cell (Mmus) def: "A olfactory ensheathing cell of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Apod (Mmus), Mybpc1 (Mmus), Rasgef1c (Mmus). It is distinguished from other OEC cells by expression of Rasgef1c. It is glutamatergic (inferred from expression of Slc17a7). These cells are located in the brain . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5292 OEC NN_1." [https://doi.org/10.1038/s41586-023-06812-z] comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions. subset: mouse_subset synonym: "5292 OEC NN_1" EXACT [] is_a: CL:0000151 ! secretory cell is_a: CL:4301615 ! olfactory ensheathing cell (Mmus) relationship: RO:0002215 GO:0061535 {comment="Inferred to be glutamate secretion, neurotransmission based on expression of Slc17a7"} ! capable of glutamate secretion, neurotransmission property_value: CLM:0010001 MBA:997 {CLM:0010002="0.85", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF broad region."} property_value: CLM:0010003 CLM:5007042 {STATO:0000663="0.09259259"} property_value: CLM:0010003 CLM:5022262 {STATO:0000663="0.46153846"} property_value: IAO:0000028 "OEC NN_1 Rasgef1c (Mmus)" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#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%2BDggl%2FA4SgGoeExD3ZBDJOUVRJRTdUQU1QOFBRQUhPNFAABYGvpkqB6awOgaCBR4CS1egGAAcAAAUABgEBAkNCR0MwVTMwVlY5SlBSNjBUSlUAA34AAAAEAAAIVkZPRllQRlFHUktVRFFVWjNGRgAJTFZEQkpBVzhCSTVZU1MxUVVCRwAKAAsBVExPS1dDTDk1UlUwM0Q5UEVURwACNzNHVlREWERFR0UyN00yWEpNVAADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAACAwA%3D" xsd:string {name="Reference data on Allen Brain Cell Atlas"} property_value: seeAlso "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_32.h5ad" xsd:string {comment="Warning large data file!", name="h5ad data file for CS20230722_CLAS_32"} [Term] id: CL:4307113 name: ABC NN_1 Pde11a arachnoid barrier cell (Mmus) def: "A arachnoid barrier cell of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Slc47a1 (Mmus), Pde11a (Mmus). It is distinguished from other ABC NN cells by expression of Pde11a. These cells are located in the brain . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5293 ABC NN_1." [https://doi.org/10.1038/s41586-023-06812-z] comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions. subset: mouse_subset synonym: "5293 ABC NN_1" EXACT [] is_a: CL:4301616 ! arachnoid barrier cell (Mmus) property_value: CLM:0010001 MBA:997 {CLM:0010002="0.73", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF broad region."} property_value: CLM:0010003 CLM:5007043 {STATO:0000663="0.6603774"} property_value: CLM:0010003 CLM:5022263 {STATO:0000663="0.7876712"} property_value: IAO:0000028 "ABC NN_1 Pde11a (Mmus)" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#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%2BDggl%2FA4SgGoeExD3ZBDJOUVRJRTdUQU1QOFBRQUhPNFAABYGvpkqB6awOgaCBR4CS1egGAAcAAAUABgEBAkNCR0MwVTMwVlY5SlBSNjBUSlUAA34AAAAEAAAIVkZPRllQRlFHUktVRFFVWjNGRgAJTFZEQkpBVzhCSTVZU1MxUVVCRwAKAAsBVExPS1dDTDk1UlUwM0Q5UEVURwACNzNHVlREWERFR0UyN00yWEpNVAADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAACAwA%3D" xsd:string {name="Reference data on Allen Brain Cell Atlas"} property_value: seeAlso "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_33.h5ad" xsd:string {comment="Warning large data file!", name="h5ad data file for CS20230722_CLAS_33"} [Term] id: CL:4307114 name: ABC NN_1 Dapl1 arachnoid barrier cell (Mmus) def: "A arachnoid barrier cell of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Slc47a1 (Mmus), Dapl1 (Mmus). It is distinguished from other ABC NN cells by expression of Dapl1. These cells are located in the brain . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5294 ABC NN_1." [https://doi.org/10.1038/s41586-023-06812-z] comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions. subset: mouse_subset synonym: "5294 ABC NN_1" EXACT [] is_a: CL:4301616 ! arachnoid barrier cell (Mmus) property_value: CLM:0010001 MBA:997 {CLM:0010002="0.76", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF broad region."} property_value: CLM:0010003 CLM:5007044 {STATO:0000663="0.6818182"} property_value: CLM:0010003 CLM:5022264 {STATO:0000663="0.023364486"} property_value: IAO:0000028 "ABC NN_1 Dapl1 (Mmus)" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#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%2BDggl%2FA4SgGoeExD3ZBDJOUVRJRTdUQU1QOFBRQUhPNFAABYGvpkqB6awOgaCBR4CS1egGAAcAAAUABgEBAkNCR0MwVTMwVlY5SlBSNjBUSlUAA34AAAAEAAAIVkZPRllQRlFHUktVRFFVWjNGRgAJTFZEQkpBVzhCSTVZU1MxUVVCRwAKAAsBVExPS1dDTDk1UlUwM0Q5UEVURwACNzNHVlREWERFR0UyN00yWEpNVAADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAACAwA%3D" xsd:string {name="Reference data on Allen Brain Cell Atlas"} property_value: seeAlso "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_33.h5ad" xsd:string {comment="Warning large data file!", name="h5ad data file for CS20230722_CLAS_33"} [Term] id: CL:4307115 name: ABC NN_1 Cubn arachnoid barrier cell (Mmus) def: "A arachnoid barrier cell of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Prg4 (Mmus), Cubn (Mmus). It is distinguished from other ABC NN cells by expression of Cubn. These cells are located in the brain . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5295 ABC NN_1." [https://doi.org/10.1038/s41586-023-06812-z] comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions. subset: mouse_subset synonym: "5295 ABC NN_1" EXACT [] is_a: CL:4301616 ! arachnoid barrier cell (Mmus) property_value: CLM:0010001 MBA:997 {CLM:0010002="0.74", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF broad region."} property_value: CLM:0010003 CLM:5007045 {STATO:0000663="0.86419755"} property_value: CLM:0010003 CLM:5022265 {STATO:0000663="0.9"} property_value: IAO:0000028 "ABC NN_1 Cubn (Mmus)" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#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%2BDggl%2FA4SgGoeExD3ZBDJOUVRJRTdUQU1QOFBRQUhPNFAABYGvpkqB6awOgaCBR4CS1egGAAcAAAUABgEBAkNCR0MwVTMwVlY5SlBSNjBUSlUAA34AAAAEAAAIVkZPRllQRlFHUktVRFFVWjNGRgAJTFZEQkpBVzhCSTVZU1MxUVVCRwAKAAsBVExPS1dDTDk1UlUwM0Q5UEVURwACNzNHVlREWERFR0UyN00yWEpNVAADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAACAwA%3D" xsd:string {name="Reference data on Allen Brain Cell Atlas"} property_value: seeAlso "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_33.h5ad" xsd:string {comment="Warning large data file!", name="h5ad data file for CS20230722_CLAS_33"} [Term] id: CL:4307132 name: microglial cell (Mmus) def: "A microglial cell of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of C1qa (Mmus), Tmem119 (Mmus). It is distinguished from other Immune cells by expression of C1qa, Tmem119. These cells are located in the Isocortex, brain . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5312 Microglia NN_1." [https://doi.org/10.1038/s41586-023-06812-z] comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions. subset: mouse_subset synonym: "1194 Microglia NN_1" EXACT [] synonym: "334 Microglia NN" EXACT [] synonym: "5312 Microglia NN_1" EXACT [] is_a: CL:0000129 ! microglial cell relationship: RO:0002162 NCBITaxon:10090 ! in taxon Mus musculus property_value: CLM:0010001 MBA:315 {CLM:0010002="0.29", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF broad region."} property_value: CLM:0010001 MBA:997 {CLM:0010002="0.17", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF broad region."} property_value: CLM:0010003 CLM:5007062 {STATO:0000663="0.982906"} property_value: CLM:0010003 CLM:5007994 {STATO:0000663="0.9684685"} property_value: CLM:0010003 CLM:5022282 property_value: IAO:0000028 "Microglia NN (Mmus)" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#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%2BDggl%2FA4SgGoeExD3ZBDJOUVRJRTdUQU1QOFBRQUhPNFAABYGvpkqB6awOgaCBR4CS1egGAAcAAAUABgEBAlFZNVM4S01PNUhMSlVGMFAwMEsAA34AAAAEAAAIVkZPRllQRlFHUktVRFFVWjNGRgAJTFZEQkpBVzhCSTVZU1MxUVVCRwAKAAsBVExPS1dDTDk1UlUwM0Q5UEVURwACNzNHVlREWERFR0UyN00yWEpNVAADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAACAwA%3D" xsd:string {name="Reference data on Allen Brain Cell Atlas"} property_value: seeAlso "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_34.h5ad" xsd:string {comment="Warning large data file!", name="h5ad data file for CS20230722_CLAS_34"} [Term] id: CL:4307133 name: BAM NN_1 Mrc1 border associated macrophage (Mmus) def: "A border associated macrophage of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Mrc1 (Mmus), Pf4 (Mmus). It is distinguished from other BAM NN cells by expression of Mrc1, Pf4. These cells are located in the Medulla, Cerebellum, brain . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5313 BAM NN_1." [https://doi.org/10.1038/s41586-023-06812-z] comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions. subset: mouse_subset synonym: "5313 BAM NN_1" EXACT [] is_a: CL:4301625 ! border associated macrophage (Mmus) property_value: CLM:0010001 MBA:354 {CLM:0010002="0.1", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF broad region."} property_value: CLM:0010001 MBA:512 {CLM:0010002="0.13", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF broad region."} property_value: CLM:0010001 MBA:997 {CLM:0010002="0.34", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF broad region."} property_value: CLM:0010003 CLM:5007063 {STATO:0000663="0.5479452"} property_value: CLM:0010003 CLM:5022283 {STATO:0000663="0.16666667"} property_value: IAO:0000028 "BAM NN_1 Mrc1 (Mmus)" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIAAAFDQkdDMFUzMFZWOUpQUjYwVEpVAAIBNTMxMyBCQU0gTk5fMQAABAEBAoGsxo6BlhUgA4RqTf2EWBhNAAUABgEBAkNCR0MwVTMwVlY5SlBSNjBUSlUAA34AAAAEAAAIRzRJNEdGSlhKQjlBVFozUFRYMQAJTFZEQkpBVzhCSTVZU1MxUVVCRwAKAAsBbm9uZQACbm9uZQADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAABSzlKTjIzUDI0S1FDR0s5VTc1QQACSFNZWlBaVzE2NjlVODIxQldZUAADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIAAAFDQkdDMFUzMFZWOUpQUjYwVEpVAAIBNTMxMyBCQU0gTk5fMQAABAEAAoRQvx%2BDggl%2FA4SgGoeExD3ZBDJOUVRJRTdUQU1QOFBRQUhPNFAABYGvpkqB6awOgaCBR4CS1egGAAcAAAUABgEBAkNCR0MwVTMwVlY5SlBSNjBUSlUAA34AAAAEAAAIVkZPRllQRlFHUktVRFFVWjNGRgAJTFZEQkpBVzhCSTVZU1MxUVVCRwAKAAsBVExPS1dDTDk1UlUwM0Q5UEVURwACNzNHVlREWERFR0UyN00yWEpNVAADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAACAwA%3D" xsd:string {name="Reference data on Allen Brain Cell Atlas"} property_value: seeAlso "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_34.h5ad" xsd:string {comment="Warning large data file!", name="h5ad data file for CS20230722_CLAS_34"} [Term] id: CL:4307134 name: BAM NN_1 Fos border associated macrophage (Mmus) def: "A border associated macrophage of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Mrc1 (Mmus), Pf4 (Mmus), Fos (Mmus). It is distinguished from other BAM NN cells by expression of Fos. These cells are located in the Isocortex, Cerebellum, brain . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5314 BAM NN_1." [https://doi.org/10.1038/s41586-023-06812-z] comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions. subset: mouse_subset synonym: "5314 BAM NN_1" EXACT [] is_a: CL:4301625 ! border associated macrophage (Mmus) property_value: CLM:0010001 MBA:315 {CLM:0010002="0.14", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF broad region."} property_value: CLM:0010001 MBA:512 {CLM:0010002="0.16", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF broad region."} property_value: CLM:0010001 MBA:997 {CLM:0010002="0.26", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF broad region."} property_value: CLM:0010003 CLM:5007064 {STATO:0000663="0.7746479"} property_value: CLM:0010003 CLM:5022284 {STATO:0000663="0.8695652"} property_value: IAO:0000028 "BAM NN_1 Fos (Mmus)" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#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%2BDggl%2FA4SgGoeExD3ZBDJOUVRJRTdUQU1QOFBRQUhPNFAABYGvpkqB6awOgaCBR4CS1egGAAcAAAUABgEBAkNCR0MwVTMwVlY5SlBSNjBUSlUAA34AAAAEAAAIVkZPRllQRlFHUktVRFFVWjNGRgAJTFZEQkpBVzhCSTVZU1MxUVVCRwAKAAsBVExPS1dDTDk1UlUwM0Q5UEVURwACNzNHVlREWERFR0UyN00yWEpNVAADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAACAwA%3D" xsd:string {name="Reference data on Allen Brain Cell Atlas"} property_value: seeAlso "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20230722_CLAS_34.h5ad" xsd:string {comment="Warning large data file!", name="h5ad data file for CS20230722_CLAS_34"} [Term] id: CL:4310083 name: GPin-BF cholinergic-GABAergic neuron (Primate) def: "A GABA-Chol neuron of the Primates brain. These cells are located in the striatum, external segment of globus pallidus . Reference transcriptomic data for this type can be found in the dataset/taxonomy - HMBA Basal Ganglia Consensus Taxonomy in cell set Group:GPin-BF Cholinergic GABA." [https://alleninstitute.github.io/HMBA_BasalGanglia_Consensus_Taxonomy/] comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions. subset: human_subset subset: mouse_subset synonym: "GPin-BF Cholinergic GABA" EXACT [] is_a: CL:0008061 ! GABA-Chol neuron property_value: CLM:0010001 DHBA:10333 {CLM:0010002="0.2", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF broad region."} property_value: CLM:0010001 DHBA:10343 {CLM:0010002="0.1", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF broad region."} property_value: IAO:0000028 "GPin-BF Cholinergic GABA (Primate)" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#AQQBTlhKOU5aQVFBNU1FSFFOT1dKUQACVEdCUTJGRVYyN04wQ1BMS1ZBWgADBQFFM0hHQllIUkM5OEdBNkZXOUY2AAIAAAEzWEJPRkJSMzAyRVlDMFVRRDUxAAIAAAFTUTZXSk8wR05VSkdGVThMSFZWAAIAAAFISzE0TzFBU0FOUFlIT05GTExRAAIBR1Bpbi1CRiBDaG9saW5lcmdpYyBHQUJBAAABNkVXQlNFSjRZRlZHS0kyQVBCTAACAAAEAQAChMpFmYR%2BVoYDhQxy%2FoU8XEUEV01QOE5NSjVEOFhPMUFPSTFMOQAFg2xvMYI24kGDwAnEgzgCUgAFAAYBAQJISzE0TzFBU0FOUFlIT05GTExRAAN%2BAAAABAAACElBNlk2U043UVpTSUVKMEZaMFUACVBPWjJIQ1BCVDYwRFNESjhVQTcACgALATc0MTZCNVhKRFNZMEhERjkzUk8AAkNSRUhSQ0syWVhSV0pLMkowQUwAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAVZNNEU2SjlEUFlZRDdFMEJITkIAAktHWkxBV0lQQ1I0Vzk4RjVMRDYAAwUBRTNIR0JZSFJDOThHQTZGVzlGNgACAAABM1hCT0ZCUjMwMkVZQzBVUUQ1MQACAAABU1E2V0pPMEdOVUpHRlU4TEhWVgACAAABSEsxNE8xQVNBTlBZSE9ORkxMUQACAUdQaW4tQkYgQ2hvbGluZXJnaWMgR0FCQQAAATZFV0JTRUo0WUZWR0tJMkFQQkwAAgAABAEAAoX%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%2Bp7yQAFAAYBAQJISzE0TzFBU0FOUFlIT05GTExRAAN%2BAAAABAAACEZUTEFVT1Y2U0xCMDcxU1ZOVTkACVBPWjJIQ1BCVDYwRFNESjhVQTcACgALAW5vbmUAAm5vbmUAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAggA" xsd:string {name="Reference data on Allen Brain Cell Atlas"} property_value: seeAlso "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20250428_NEIGH_0002.h5ad" xsd:string {comment="Warning large data file!", name="h5ad data file for CS20250428_NEIGH_0002"} [Term] id: CL:4310084 name: striatal LAMP5 CXCL14 GABAergic interneuron (Primate) def: "A lamp5 GABAergic interneuron of the Primates brain. These cells are located in the striatum . Reference transcriptomic data for this type can be found in the dataset/taxonomy - HMBA Basal Ganglia Consensus Taxonomy in cell set Group:LAMP5-CXCL14 GABA." [https://alleninstitute.github.io/HMBA_BasalGanglia_Consensus_Taxonomy/] comment: Based on annotation transfer evidence with MapMyCells, this may not represent a transcriptomicallly distinct cell type, but rather the population of LAMP5 GABAergic neurons located in the striatum. Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions. subset: human_subset subset: mouse_subset synonym: "CN LAMP5-CXCL14 GABA" EXACT [] synonym: "LAMP5" EXACT [] synonym: "LAMP5-CXCL14 GABA" EXACT [] is_a: CL:4023011 ! lamp5 GABAergic interneuron property_value: CLM:0010001 DHBA:10333 {CLM:0010002="0.5", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF broad region."} property_value: CLM:0010003 CLM:5050484 property_value: IAO:0000028 "LAMP5-CXCL14 GABA (Primate)" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#AQQBTlhKOU5aQVFBNU1FSFFOT1dKUQACVEdCUTJGRVYyN04wQ1BMS1ZBWgADBQFFM0hHQllIUkM5OEdBNkZXOUY2AAIAAAEzWEJPRkJSMzAyRVlDMFVRRDUxAAIAAAFTUTZXSk8wR05VSkdGVThMSFZWAAIAAAFISzE0TzFBU0FOUFlIT05GTExRAAIBTEFNUDUtQ1hDTDE0IEdBQkEAAAE2RVdCU0VKNFlGVkdLSTJBUEJMAAIAAAQBAAKEykWZhH5WhgOFDHL%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%2FlmIhY7XHwOGCqZOhfScqgRXTVA4Tk1KNUQ4WE8xQU9JMUw5AAWEFMQWg4zFUoRiab%2BEtOdLBgAHAAAFAAYBAQJISzE0TzFBU0FOUFlIT05GTExRAAN%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%2BA4Re3WaD6nvJAAUABgEBAkhLMTRPMUFTQU5QWUhPTkZMTFEAA34AAAAEAAAIRlRMQVVPVjZTTEIwNzFTVk5VOQAJUE9aMkhDUEJUNjBEU0RKOFVBNwAKAAsBbm9uZQACbm9uZQADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAACCAA%3D" xsd:string {name="Reference data on Allen Brain Cell Atlas"} property_value: seeAlso "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20250428_NEIGH_0002.h5ad" xsd:string {comment="Warning large data file!", name="h5ad data file for CS20250428_NEIGH_0002"} [Term] id: CL:4310085 name: striatal LAMP5 LHX6 GABAergic interneuron (Primate) def: "A Lamp5 Lhx6 neuron of the Primates brain. These cells are located in the striatum . Reference transcriptomic data for this type can be found in the dataset/taxonomy - HMBA Basal Ganglia Consensus Taxonomy in cell set Group:LAMP5-LHX6 GABA." [https://alleninstitute.github.io/HMBA_BasalGanglia_Consensus_Taxonomy/] comment: Based on annotation transfer evidence with MapMyCells, this may not represent a transcriptomicallly distinct cell type, but rather the population of LAMP5 LHX6 GABAergic neurons located in the striatum. Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions. subset: human_subset subset: mouse_subset synonym: "CN LAMP5-LHX6 GABA" EXACT [] synonym: "LAMP5-LHX6 GABA" EXACT [] is_a: CL:4042013 ! Lamp5 Lhx6 neuron property_value: CLM:0010001 DHBA:10333 {CLM:0010002="0.5", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF broad region."} property_value: CLM:0010003 CLM:5050485 property_value: IAO:0000028 "LAMP5-LHX6 GABA (Primate)" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#AQQBTlhKOU5aQVFBNU1FSFFOT1dKUQACVEdCUTJGRVYyN04wQ1BMS1ZBWgADBQFFM0hHQllIUkM5OEdBNkZXOUY2AAIAAAEzWEJPRkJSMzAyRVlDMFVRRDUxAAIAAAFTUTZXSk8wR05VSkdGVThMSFZWAAIAAAFISzE0TzFBU0FOUFlIT05GTExRAAIBTEFNUDUtTEhYNiBHQUJBAAABNkVXQlNFSjRZRlZHS0kyQVBCTAACAAAEAQAChMpFmYR%2BVoYDhQxy%2FoU8XEUEV01QOE5NSjVEOFhPMUFPSTFMOQAFg2xvMYI24kGDwAnEgzgCUgAFAAYBAQJISzE0TzFBU0FOUFlIT05GTExRAAN%2BAAAABAAACElBNlk2U043UVpTSUVKMEZaMFUACVBPWjJIQ1BCVDYwRFNESjhVQTcACgALATc0MTZCNVhKRFNZMEhERjkzUk8AAkNSRUhSQ0syWVhSV0pLMkowQUwAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAVZNNEU2SjlEUFlZRDdFMEJITkIAAktHWkxBV0lQQ1I0Vzk4RjVMRDYAAwUBRTNIR0JZSFJDOThHQTZGVzlGNgACAAABM1hCT0ZCUjMwMkVZQzBVUUQ1MQACAAABU1E2V0pPMEdOVUpHRlU4TEhWVgACAAABSEsxNE8xQVNBTlBZSE9ORkxMUQACAUxBTVA1LUxIWDYgR0FCQQAAATZFV0JTRUo0WUZWR0tJMkFQQkwAAgAABAEAAoX%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%2Bp7yQAFAAYBAQJISzE0TzFBU0FOUFlIT05GTExRAAN%2BAAAABAAACEZUTEFVT1Y2U0xCMDcxU1ZOVTkACVBPWjJIQ1BCVDYwRFNESjhVQTcACgALAW5vbmUAAm5vbmUAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAggA" xsd:string {name="Reference data on Allen Brain Cell Atlas"} property_value: seeAlso "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20250428_NEIGH_0002.h5ad" xsd:string {comment="Warning large data file!", name="h5ad data file for CS20250428_NEIGH_0002"} [Term] id: CL:4310088 name: BF SKOR1 Glut glutamatergic neuron of the basal ganglia (Primate) def: "A glutamatergic neuron of the basal ganglia of the Primates brain. These cells are located in the striatum, external segment of globus pallidus . Reference transcriptomic data for this type can be found in the dataset/taxonomy - HMBA Basal Ganglia Consensus Taxonomy in cell set Group:BF SKOR1 Glut." [https://alleninstitute.github.io/HMBA_BasalGanglia_Consensus_Taxonomy/] comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions. subset: human_subset subset: mouse_subset synonym: "BF SKOR1 Glut" EXACT [] is_a: CL:4042040 ! glutamatergic neuron of the basal ganglia property_value: CLM:0010001 DHBA:10333 {CLM:0010002="0.2", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF broad region."} property_value: CLM:0010001 DHBA:10343 {CLM:0010002="0.1", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF broad region."} property_value: IAO:0000028 "BF SKOR1 Glut (Primate)" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#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%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%3D%3D" xsd:string {name="Reference data on Allen Brain Cell Atlas"} property_value: seeAlso "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20250428_NEIGH_0000.h5ad" xsd:string {comment="Warning large data file!", name="h5ad data file for CS20250428_NEIGH_0000"} [Term] id: CL:4310093 name: arkypallidal neuron (Primate) def: "A arkypallidal neuron of the Primates brain. These cells are located in the striatum, external segment of globus pallidus . Reference transcriptomic data for this type can be found in the dataset/taxonomy - HMBA Basal Ganglia Consensus Taxonomy in cell set Group:GPe MEIS2-SOX6 GABA." [https://alleninstitute.github.io/HMBA_BasalGanglia_Consensus_Taxonomy/, https://doi.org/10.1016/j.neuron.2015.03.007, https://doi.org/10.1038/s41593-023-01368-7, https://doi.org/10.1523/JNEUROSCI.4662-14.2015] comment: Rationale for assigning this type to reference data: Mapping to the arkypallidal neuron is based on location (GPe), expression of GAD1/2, FOXP2, MEIS2, and NPAS1 and lack of expression of canonical pallidal markers NKX2-1 and LHX6, SST and PV. Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions. {xref="https://doi.org/10.1038/s41593-023-01368-7", xref="https://doi.org/10.1016/j.neuron.2015.03.007", xref="https://doi.org/10.1523/JNEUROSCI.4662-14.2015"} subset: human_subset subset: mouse_subset synonym: "CN MEIS2 GABA" EXACT [] synonym: "GPe MEIS2-SOX6 GABA" EXACT [] is_a: CL:0020010 ! arkypallidal neuron property_value: CLM:0010001 DHBA:10333 {CLM:0010002="0.2", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF broad region."} property_value: CLM:0010001 DHBA:10343 {CLM:0010002="0.5", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF broad region."} property_value: CLM:0010003 CLM:5050493 property_value: IAO:0000028 "GPe MEIS2-SOX6 GABA (Primate)" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#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%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%3D%3D" xsd:string {name="Reference data on Allen Brain Cell Atlas"} property_value: seeAlso "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20250428_NEIGH_0002.h5ad" xsd:string {comment="Warning large data file!", name="h5ad data file for CS20250428_NEIGH_0002"} [Term] id: CL:4310094 name: prototypic neuron (Primate) def: "A prototypic neuron of the Primates brain. These cells are located in the striatum, external segment of globus pallidus . Reference transcriptomic data for this type can be found in the dataset/taxonomy - HMBA Basal Ganglia Consensus Taxonomy in cell set Group:GPe SOX6-CTXND1 GABA." [https://alleninstitute.github.io/HMBA_BasalGanglia_Consensus_Taxonomy/, https://doi.org/10.1016/j.neuron.2015.03.007] comment: Rationale for assigning this type to reference data: Mapping to the general type of prototypic neuron is based on location (GPe) and expression of Nkx2-1. Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions. {xref="https://doi.org/10.1016/j.neuron.2015.03.007"} subset: human_subset subset: mouse_subset synonym: "GPe SOX6-CTXND1 GABA" EXACT [] is_a: CL:0020009 ! prototypic neuron property_value: CLM:0010001 DHBA:10333 {CLM:0010002="0.1", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF broad region."} property_value: CLM:0010001 DHBA:10343 {CLM:0010002="0.8", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF broad region."} property_value: CLM:0010003 CLM:5050494 property_value: IAO:0000028 "GPe SOX6-CTXND1 GABA (Primate)" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#AQQBTlhKOU5aQVFBNU1FSFFOT1dKUQACVEdCUTJGRVYyN04wQ1BMS1ZBWgADBQFFM0hHQllIUkM5OEdBNkZXOUY2AAIAAAEzWEJPRkJSMzAyRVlDMFVRRDUxAAIAAAFTUTZXSk8wR05VSkdGVThMSFZWAAIAAAFISzE0TzFBU0FOUFlIT05GTExRAAIBR1BlIFNPWDYtQ1RYTkQxIEdBQkEAAAE2RVdCU0VKNFlGVkdLSTJBUEJMAAIAAAQBAAKEykWZhH5WhgOFDHL%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%2FlmIhY7XHwOGCqZOhfScqgRXTVA4Tk1KNUQ4WE8xQU9JMUw5AAWEFMQWg4zFUoRiab%2BEtOdLBgAHAAAFAAYBAQJISzE0TzFBU0FOUFlIT05GTExRAAN%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%2BA4Re3WaD6nvJAAUABgEBAkhLMTRPMUFTQU5QWUhPTkZMTFEAA34AAAAEAAAIRlRMQVVPVjZTTEIwNzFTVk5VOQAJUE9aMkhDUEJUNjBEU0RKOFVBNwAKAAsBbm9uZQACbm9uZQADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAACCAA%3D" xsd:string {name="Reference data on Allen Brain Cell Atlas"} property_value: seeAlso "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20250428_NEIGH_0002.h5ad" xsd:string {comment="Warning large data file!", name="h5ad data file for CS20250428_NEIGH_0002"} [Term] id: CL:4310095 name: GPi Core neuron (Primate) def: "A internal globus pallidus core projecting neuron of the Primates brain. These cells are located in the internal segment of globus pallidus . Reference transcriptomic data for this type can be found in the dataset/taxonomy - HMBA Basal Ganglia Consensus Taxonomy in cell set Group:GPi Core." [https://alleninstitute.github.io/HMBA_BasalGanglia_Consensus_Taxonomy/, https://doi.org/10.1016/j.neuron.2017.03.017, https://doi.org/10.1523/ENEURO.0208-22.2022] comment: Rationale for assigning this type to reference data: Mapping to the general GPi core cell type is based on location (to GPi, nested inside GPi shell neurons), predicted neurotransmitter (GABA), and expression of Pvalb. Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions. {xref="https://doi.org/10.1523/ENEURO.0208-22.2022", xref="https://doi.org/10.1016/j.neuron.2017.03.017"} subset: human_subset subset: mouse_subset synonym: "CN ONECUT1 GABA" EXACT [] synonym: "GPi Core" EXACT [] is_a: CL:0020003 ! internal globus pallidus core projecting neuron property_value: CLM:0010001 DHBA:10344 {CLM:0010002="0.9", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF broad region."} property_value: CLM:0010003 CLM:5050495 property_value: IAO:0000028 "GPi Core (Primate)" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#AQQBTlhKOU5aQVFBNU1FSFFOT1dKUQACVEdCUTJGRVYyN04wQ1BMS1ZBWgADBQFFM0hHQllIUkM5OEdBNkZXOUY2AAIAAAEzWEJPRkJSMzAyRVlDMFVRRDUxAAIAAAFTUTZXSk8wR05VSkdGVThMSFZWAAIAAAFISzE0TzFBU0FOUFlIT05GTExRAAIBR1BpIENvcmUAAAE2RVdCU0VKNFlGVkdLSTJBUEJMAAIAAAQBAAKEykWZhH5WhgOFDHL%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%2FlmIhY7XHwOGCqZOhfScqgRXTVA4Tk1KNUQ4WE8xQU9JMUw5AAWEFMQWg4zFUoRiab%2BEtOdLBgAHAAAFAAYBAQJISzE0TzFBU0FOUFlIT05GTExRAAN%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%2BA4Re3WaD6nvJAAUABgEBAkhLMTRPMUFTQU5QWUhPTkZMTFEAA34AAAAEAAAIRlRMQVVPVjZTTEIwNzFTVk5VOQAJUE9aMkhDUEJUNjBEU0RKOFVBNwAKAAsBbm9uZQACbm9uZQADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAACCAA%3D" xsd:string {name="Reference data on Allen Brain Cell Atlas"} property_value: seeAlso "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20250428_NEIGH_0002.h5ad" xsd:string {comment="Warning large data file!", name="h5ad data file for CS20250428_NEIGH_0002"} [Term] id: CL:4310096 name: GPi Shell neuron (Primate) def: "A internal globus pallidus shell projection neuron of the Primates brain. These cells are located in the striatum, external segment of globus pallidus, internal segment of globus pallidus . Reference transcriptomic data for this type can be found in the dataset/taxonomy - HMBA Basal Ganglia Consensus Taxonomy in cell set Group:GPi Shell." [https://alleninstitute.github.io/HMBA_BasalGanglia_Consensus_Taxonomy/, https://doi.org/10.1016/j.neuron.2017.03.017, https://doi.org/10.1523/ENEURO.0208-22.2022] comment: Rationale for assigning this type to reference data: Mapping to the general type GPi shell neuron (internal globus pallidus shell projection neuron) is based on soma location (to GPi & surrounding GPi core neurons), neurotransmitter (dual GABA-Glut), expression of sst, Sst,Tbr1,Slc17a6 and absence of Pvalb expression. Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions. {xref="https://doi.org/10.1523/ENEURO.0208-22.2022", xref="https://doi.org/10.1016/j.neuron.2017.03.017"} subset: human_subset synonym: "CN GABA-Glut" EXACT [] synonym: "GPi Shell" EXACT [] synonym: "Subpallium GABA-Glut" EXACT [] is_a: CL:0020004 ! internal globus pallidus shell projection neuron relationship: RO:0002162 NCBITaxon:9443 ! in taxon Primates property_value: CLM:0010001 DHBA:10333 {CLM:0010002="0.1", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF broad region."} property_value: CLM:0010001 DHBA:10343 {CLM:0010002="0.1", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF broad region."} property_value: CLM:0010001 DHBA:10344 {CLM:0010002="0.6", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF broad region."} property_value: CLM:0010003 CLM:5050496 property_value: IAO:0000028 "GPi Shell (Primate)" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#AQQBTlhKOU5aQVFBNU1FSFFOT1dKUQACVEdCUTJGRVYyN04wQ1BMS1ZBWgADBQFFM0hHQllIUkM5OEdBNkZXOUY2AAIAAAEzWEJPRkJSMzAyRVlDMFVRRDUxAAIBQ04gR0FCQS1HbHV0AAABU1E2V0pPMEdOVUpHRlU4TEhWVgACAAABSEsxNE8xQVNBTlBZSE9ORkxMUQACAAABNkVXQlNFSjRZRlZHS0kyQVBCTAACAAAEAQAChMpFmYR%2BVoYDhQxy%2FoU8XEUEV01QOE5NSjVEOFhPMUFPSTFMOQAFg2xvMYI24kGDwAnEgzgCUgAFAAYBAQIzWEJPRkJSMzAyRVlDMFVRRDUxAAN%2BAAAABAAACElBNlk2U043UVpTSUVKMEZaMFUACVBPWjJIQ1BCVDYwRFNESjhVQTcACgALATc0MTZCNVhKRFNZMEhERjkzUk8AAkNSRUhSQ0syWVhSV0pLMkowQUwAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAVZNNEU2SjlEUFlZRDdFMEJITkIAAktHWkxBV0lQQ1I0Vzk4RjVMRDYAAwUBRTNIR0JZSFJDOThHQTZGVzlGNgACAAABM1hCT0ZCUjMwMkVZQzBVUUQ1MQACAUNOIEdBQkEtR2x1dAAAAVNRNldKTzBHTlVKR0ZVOExIVlYAAgAAAUhLMTRPMUFTQU5QWUhPTkZMTFEAAgAAATZFV0JTRUo0WUZWR0tJMkFQQkwAAgAABAEAAoX%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%2Bp7yQAFAAYBAQIzWEJPRkJSMzAyRVlDMFVRRDUxAAN%2BAAAABAAACEZUTEFVT1Y2U0xCMDcxU1ZOVTkACVBPWjJIQ1BCVDYwRFNESjhVQTcACgALAW5vbmUAAm5vbmUAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAggA" xsd:string {name="Reference data on Allen Brain Cell Atlas"} property_value: seeAlso "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20250428_NEIGH_0003.h5ad" xsd:string {comment="Warning large data file!", name="h5ad data file for CS20250428_NEIGH_0003"} [Term] id: CL:4310100 name: GPe-NDB-SI LHX6-LHX8-GBX1 GABA GABAergic interneuron (Primate) def: "A GABAergic interneuron of the Primates brain. These cells are located in the striatum, external segment of globus pallidus . Reference transcriptomic data for this type can be found in the dataset/taxonomy - HMBA Basal Ganglia Consensus Taxonomy in cell set Group:GPe-NDB-SI LHX6-LHX8-GBX1 GABA." [https://alleninstitute.github.io/HMBA_BasalGanglia_Consensus_Taxonomy/] comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions. subset: human_subset subset: mouse_subset synonym: "GPe-NDB-SI LHX6-LHX8-GBX1 GABA" EXACT [] is_a: CL:0011005 ! GABAergic interneuron property_value: CLM:0010001 DHBA:10333 {CLM:0010002="0.2", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF broad region."} property_value: CLM:0010001 DHBA:10343 {CLM:0010002="0.2", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF broad region."} property_value: IAO:0000028 "GPe-NDB-SI LHX6-LHX8-GBX1 GABA (Primate)" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#AQQBTlhKOU5aQVFBNU1FSFFOT1dKUQACVEdCUTJGRVYyN04wQ1BMS1ZBWgADBQFFM0hHQllIUkM5OEdBNkZXOUY2AAIAAAEzWEJPRkJSMzAyRVlDMFVRRDUxAAIAAAFTUTZXSk8wR05VSkdGVThMSFZWAAIAAAFISzE0TzFBU0FOUFlIT05GTExRAAIBR1BlLU5EQi1TSSBMSFg2LUxIWDgtR0JYMSBHQUJBAAABNkVXQlNFSjRZRlZHS0kyQVBCTAACAAAEAQAChMpFmYR%2BVoYDhQxy%2FoU8XEUEV01QOE5NSjVEOFhPMUFPSTFMOQAFg2xvMYI24kGDwAnEgzgCUgAFAAYBAQJISzE0TzFBU0FOUFlIT05GTExRAAN%2BAAAABAAACElBNlk2U043UVpTSUVKMEZaMFUACVBPWjJIQ1BCVDYwRFNESjhVQTcACgALATc0MTZCNVhKRFNZMEhERjkzUk8AAkNSRUhSQ0syWVhSV0pLMkowQUwAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAVZNNEU2SjlEUFlZRDdFMEJITkIAAktHWkxBV0lQQ1I0Vzk4RjVMRDYAAwUBRTNIR0JZSFJDOThHQTZGVzlGNgACAAABM1hCT0ZCUjMwMkVZQzBVUUQ1MQACAAABU1E2V0pPMEdOVUpHRlU4TEhWVgACAAABSEsxNE8xQVNBTlBZSE9ORkxMUQACAUdQZS1OREItU0kgTEhYNi1MSFg4LUdCWDEgR0FCQQAAATZFV0JTRUo0WUZWR0tJMkFQQkwAAgAABAEAAoX%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%2Bp7yQAFAAYBAQJISzE0TzFBU0FOUFlIT05GTExRAAN%2BAAAABAAACEZUTEFVT1Y2U0xCMDcxU1ZOVTkACVBPWjJIQ1BCVDYwRFNESjhVQTcACgALAW5vbmUAAm5vbmUAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAggA" xsd:string {name="Reference data on Allen Brain Cell Atlas"} property_value: seeAlso "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20250428_NEIGH_0002.h5ad" xsd:string {comment="Warning large data file!", name="h5ad data file for CS20250428_NEIGH_0002"} [Term] id: CL:4310104 name: Islands of Calleja granule cell (Primate) def: "A Island of Calleja granule cell of the Primates brain. These cells are located in the striatum . Reference transcriptomic data for this type can be found in the dataset/taxonomy - HMBA Basal Ganglia Consensus Taxonomy in cell set Group:OT D1 ICj." [https://alleninstitute.github.io/HMBA_BasalGanglia_Consensus_Taxonomy/, https://doi.org/10.1016/j.cub.2021.10.015] comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions. {xref="https://doi.org/10.1016/j.cub.2021.10.015"} subset: human_subset subset: mouse_subset synonym: "D1-ICj (Islands of Calleja)" EXACT [] synonym: "OT D1 ICj" EXACT [] synonym: "OT Granular GABA" EXACT [] is_a: CL:4030053 ! Islands of Calleja granule cell property_value: CLM:0010001 DHBA:10333 {CLM:0010002="1.0", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF broad region."} property_value: CLM:0010003 CLM:5050504 property_value: IAO:0000028 "OT D1 ICj (Primate)" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#AQQBTlhKOU5aQVFBNU1FSFFOT1dKUQACVEdCUTJGRVYyN04wQ1BMS1ZBWgADBQFFM0hHQllIUkM5OEdBNkZXOUY2AAIAAAEzWEJPRkJSMzAyRVlDMFVRRDUxAAIAAAFTUTZXSk8wR05VSkdGVThMSFZWAAIAAAFISzE0TzFBU0FOUFlIT05GTExRAAIBT1QgRDEgSUNqAAABNkVXQlNFSjRZRlZHS0kyQVBCTAACAAAEAQAChMpFmYR%2BVoYDhQxy%2FoU8XEUEV01QOE5NSjVEOFhPMUFPSTFMOQAFg2xvMYI24kGDwAnEgzgCUgAFAAYBAQJISzE0TzFBU0FOUFlIT05GTExRAAN%2BAAAABAAACElBNlk2U043UVpTSUVKMEZaMFUACVBPWjJIQ1BCVDYwRFNESjhVQTcACgALATc0MTZCNVhKRFNZMEhERjkzUk8AAkNSRUhSQ0syWVhSV0pLMkowQUwAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAVZNNEU2SjlEUFlZRDdFMEJITkIAAktHWkxBV0lQQ1I0Vzk4RjVMRDYAAwUBRTNIR0JZSFJDOThHQTZGVzlGNgACAAABM1hCT0ZCUjMwMkVZQzBVUUQ1MQACAAABU1E2V0pPMEdOVUpHRlU4TEhWVgACAAABSEsxNE8xQVNBTlBZSE9ORkxMUQACAU9UIEQxIElDagAAATZFV0JTRUo0WUZWR0tJMkFQQkwAAgAABAEAAoX%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%2Bp7yQAFAAYBAQJISzE0TzFBU0FOUFlIT05GTExRAAN%2BAAAABAAACEZUTEFVT1Y2U0xCMDcxU1ZOVTkACVBPWjJIQ1BCVDYwRFNESjhVQTcACgALAW5vbmUAAm5vbmUAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAggA" xsd:string {name="Reference data on Allen Brain Cell Atlas"} property_value: seeAlso "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20250428_NEIGH_0002.h5ad" xsd:string {comment="Warning large data file!", name="h5ad data file for CS20250428_NEIGH_0002"} [Term] id: CL:4310109 name: SN-VTR CALB1 Dopa substantia nigra dopaminergic neuron (Primate) def: "A substantia nigra dopaminergic neuron of the Primates brain. These cells are located in the substantia nigra . Reference transcriptomic data for this type can be found in the dataset/taxonomy - HMBA Basal Ganglia Consensus Taxonomy in cell set Group:SN-VTR CALB1 Dopa." [https://alleninstitute.github.io/HMBA_BasalGanglia_Consensus_Taxonomy/, https://doi.org/10.1038/s41467-020-17876-0] comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions. {xref="https://doi.org/10.1038/s41467-020-17876-0"} subset: human_subset subset: mouse_subset synonym: "SN-VTR CALB1 Dopa" EXACT [] is_a: CL:0000000 ! cell property_value: CLM:0010001 DHBA:12251 {CLM:0010002="0.7", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF broad region."} property_value: CLM:0010003 CLM:5050509 property_value: IAO:0000028 "SN-VTR CALB1 Dopa (Primate)" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#AQQBTlhKOU5aQVFBNU1FSFFOT1dKUQACVEdCUTJGRVYyN04wQ1BMS1ZBWgADBQFFM0hHQllIUkM5OEdBNkZXOUY2AAIAAAEzWEJPRkJSMzAyRVlDMFVRRDUxAAIAAAFTUTZXSk8wR05VSkdGVThMSFZWAAIAAAFISzE0TzFBU0FOUFlIT05GTExRAAIBU04tVlRSIENBTEIxIERvcGEAAAE2RVdCU0VKNFlGVkdLSTJBUEJMAAIAAAQBAAKEykWZhH5WhgOFDHL%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%2FlmIhY7XHwOGCqZOhfScqgRXTVA4Tk1KNUQ4WE8xQU9JMUw5AAWEFMQWg4zFUoRiab%2BEtOdLBgAHAAAFAAYBAQJISzE0TzFBU0FOUFlIT05GTExRAAN%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%2BA4Re3WaD6nvJAAUABgEBAkhLMTRPMUFTQU5QWUhPTkZMTFEAA34AAAAEAAAIRlRMQVVPVjZTTEIwNzFTVk5VOQAJUE9aMkhDUEJUNjBEU0RKOFVBNwAKAAsBbm9uZQACbm9uZQADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAACCAA%3D" xsd:string {name="Reference data on Allen Brain Cell Atlas"} property_value: seeAlso "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20250428_NEIGH_0000.h5ad" xsd:string {comment="Warning large data file!", name="h5ad data file for CS20250428_NEIGH_0000"} [Term] id: CL:4310110 name: SN EBF2 GABA GABAergic interneuron (Primate) def: "A GABAergic interneuron of the Primates brain. These cells are located in the striatum, substantia nigra . Reference transcriptomic data for this type can be found in the dataset/taxonomy - HMBA Basal Ganglia Consensus Taxonomy in cell set Group:SN EBF2 GABA." [https://alleninstitute.github.io/HMBA_BasalGanglia_Consensus_Taxonomy/] comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions. subset: human_subset subset: mouse_subset synonym: "SN EBF2 GABA" EXACT [] is_a: CL:0011005 ! GABAergic interneuron property_value: CLM:0010001 DHBA:10333 {CLM:0010002="0.2", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF broad region."} property_value: CLM:0010001 DHBA:12251 {CLM:0010002="0.1", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF broad region."} property_value: IAO:0000028 "SN EBF2 GABA (Primate)" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#AQQBTlhKOU5aQVFBNU1FSFFOT1dKUQACVEdCUTJGRVYyN04wQ1BMS1ZBWgADBQFFM0hHQllIUkM5OEdBNkZXOUY2AAIAAAEzWEJPRkJSMzAyRVlDMFVRRDUxAAIAAAFTUTZXSk8wR05VSkdGVThMSFZWAAIAAAFISzE0TzFBU0FOUFlIT05GTExRAAIBU04gRUJGMiBHQUJBAAABNkVXQlNFSjRZRlZHS0kyQVBCTAACAAAEAQAChMpFmYR%2BVoYDhQxy%2FoU8XEUEV01QOE5NSjVEOFhPMUFPSTFMOQAFg2xvMYI24kGDwAnEgzgCUgAFAAYBAQJISzE0TzFBU0FOUFlIT05GTExRAAN%2BAAAABAAACElBNlk2U043UVpTSUVKMEZaMFUACVBPWjJIQ1BCVDYwRFNESjhVQTcACgALATc0MTZCNVhKRFNZMEhERjkzUk8AAkNSRUhSQ0syWVhSV0pLMkowQUwAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAVZNNEU2SjlEUFlZRDdFMEJITkIAAktHWkxBV0lQQ1I0Vzk4RjVMRDYAAwUBRTNIR0JZSFJDOThHQTZGVzlGNgACAAABM1hCT0ZCUjMwMkVZQzBVUUQ1MQACAAABU1E2V0pPMEdOVUpHRlU4TEhWVgACAAABSEsxNE8xQVNBTlBZSE9ORkxMUQACAVNOIEVCRjIgR0FCQQAAATZFV0JTRUo0WUZWR0tJMkFQQkwAAgAABAEAAoX%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%2Bp7yQAFAAYBAQJISzE0TzFBU0FOUFlIT05GTExRAAN%2BAAAABAAACEZUTEFVT1Y2U0xCMDcxU1ZOVTkACVBPWjJIQ1BCVDYwRFNESjhVQTcACgALAW5vbmUAAm5vbmUAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAggA" xsd:string {name="Reference data on Allen Brain Cell Atlas"} property_value: seeAlso "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20250428_NEIGH_0002.h5ad" xsd:string {comment="Warning large data file!", name="h5ad data file for CS20250428_NEIGH_0002"} [Term] id: CL:4310111 name: SN-VTR GAD2 Dopa dopaminergic neuron (Primate) def: "A dopaminergic neuron of the Primates brain. These cells are located in the striatum, substantia nigra . Reference transcriptomic data for this type can be found in the dataset/taxonomy - HMBA Basal Ganglia Consensus Taxonomy in cell set Group:SN-VTR GAD2 Dopa." [https://alleninstitute.github.io/HMBA_BasalGanglia_Consensus_Taxonomy/, https://doi.org/10.1101/2024.06.06.597807] comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions. {xref="https://doi.org/10.1101/2024.06.06.597807"} subset: human_subset subset: mouse_subset synonym: "SN-VTR GAD2 Dopa" EXACT [] is_a: CL:0000000 ! cell property_value: CLM:0010001 DHBA:10333 {CLM:0010002="0.1", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF broad region."} property_value: CLM:0010001 DHBA:12251 {CLM:0010002="0.3", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF broad region."} property_value: CLM:0010003 CLM:5050511 property_value: IAO:0000028 "SN-VTR GAD2 Dopa (Primate)" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#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%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%3D%3D" xsd:string {name="Reference data on Allen Brain Cell Atlas"} property_value: seeAlso "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20250428_NEIGH_0000.h5ad" xsd:string {comment="Warning large data file!", name="h5ad data file for CS20250428_NEIGH_0000"} [Term] id: CL:4310112 name: SN GATA3-PAX8 GABA GABAergic interneuron (Primate) def: "A GABAergic interneuron of the Primates brain. These cells are located in the substantia nigra . Reference transcriptomic data for this type can be found in the dataset/taxonomy - HMBA Basal Ganglia Consensus Taxonomy in cell set Group:SN GATA3-PAX8 GABA." [https://alleninstitute.github.io/HMBA_BasalGanglia_Consensus_Taxonomy/, https://doi.org/10.3389/fnins.2022.976209] comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions. {xref="https://doi.org/10.3389/fnins.2022.976209"} subset: human_subset subset: mouse_subset synonym: "pSNpr" EXACT [] synonym: "SN GATA3-PAX8 GABA" EXACT [] is_a: CL:0011005 ! GABAergic interneuron property_value: CLM:0010001 DHBA:12251 {CLM:0010002="0.9", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF broad region."} property_value: CLM:0010003 CLM:5050512 property_value: IAO:0000028 "SN GATA3-PAX8 GABA (Primate)" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#AQQBTlhKOU5aQVFBNU1FSFFOT1dKUQACVEdCUTJGRVYyN04wQ1BMS1ZBWgADBQFFM0hHQllIUkM5OEdBNkZXOUY2AAIAAAEzWEJPRkJSMzAyRVlDMFVRRDUxAAIAAAFTUTZXSk8wR05VSkdGVThMSFZWAAIAAAFISzE0TzFBU0FOUFlIT05GTExRAAIBU04gR0FUQTMtUEFYOCBHQUJBAAABNkVXQlNFSjRZRlZHS0kyQVBCTAACAAAEAQAChMpFmYR%2BVoYDhQxy%2FoU8XEUEV01QOE5NSjVEOFhPMUFPSTFMOQAFg2xvMYI24kGDwAnEgzgCUgAFAAYBAQJISzE0TzFBU0FOUFlIT05GTExRAAN%2BAAAABAAACElBNlk2U043UVpTSUVKMEZaMFUACVBPWjJIQ1BCVDYwRFNESjhVQTcACgALATc0MTZCNVhKRFNZMEhERjkzUk8AAkNSRUhSQ0syWVhSV0pLMkowQUwAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAVZNNEU2SjlEUFlZRDdFMEJITkIAAktHWkxBV0lQQ1I0Vzk4RjVMRDYAAwUBRTNIR0JZSFJDOThHQTZGVzlGNgACAAABM1hCT0ZCUjMwMkVZQzBVUUQ1MQACAAABU1E2V0pPMEdOVUpHRlU4TEhWVgACAAABSEsxNE8xQVNBTlBZSE9ORkxMUQACAVNOIEdBVEEzLVBBWDggR0FCQQAAATZFV0JTRUo0WUZWR0tJMkFQQkwAAgAABAEAAoX%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%2Bp7yQAFAAYBAQJISzE0TzFBU0FOUFlIT05GTExRAAN%2BAAAABAAACEZUTEFVT1Y2U0xCMDcxU1ZOVTkACVBPWjJIQ1BCVDYwRFNESjhVQTcACgALAW5vbmUAAm5vbmUAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAggA" xsd:string {name="Reference data on Allen Brain Cell Atlas"} property_value: seeAlso "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20250428_NEIGH_0002.h5ad" xsd:string {comment="Warning large data file!", name="h5ad data file for CS20250428_NEIGH_0002"} [Term] id: CL:4310113 name: SN GATA3-PVALB GABA GABAergic neuron (Primate) def: "A GABAergic neuron of the Primates brain. These cells are located in the substantia nigra . Reference transcriptomic data for this type can be found in the dataset/taxonomy - HMBA Basal Ganglia Consensus Taxonomy in cell set Group:SN GATA3-PVALB GABA." [https://alleninstitute.github.io/HMBA_BasalGanglia_Consensus_Taxonomy/, https://doi.org/10.3389/fnins.2022.976209] comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions. {xref="https://doi.org/10.3389/fnins.2022.976209"} subset: human_subset subset: mouse_subset synonym: "aSNpr" EXACT [] synonym: "SN GATA3-PVALB GABA" EXACT [] is_a: CL:0000000 ! cell property_value: CLM:0010001 DHBA:12251 {CLM:0010002="0.8", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF broad region."} property_value: CLM:0010003 CLM:5050513 property_value: IAO:0000028 "SN GATA3-PVALB GABA (Primate)" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#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%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%3D%3D" xsd:string {name="Reference data on Allen Brain Cell Atlas"} property_value: seeAlso "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20250428_NEIGH_0002.h5ad" xsd:string {comment="Warning large data file!", name="h5ad data file for CS20250428_NEIGH_0002"} [Term] id: CL:4310114 name: SN SEMA5A GABA GABAergic interneuron (Primate) def: "A GABAergic interneuron of the Primates brain. These cells are located in the striatum, subthalamic nucleus, substantia nigra . Reference transcriptomic data for this type can be found in the dataset/taxonomy - HMBA Basal Ganglia Consensus Taxonomy in cell set Group:SN SEMA5A GABA." [https://alleninstitute.github.io/HMBA_BasalGanglia_Consensus_Taxonomy/] comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions. subset: human_subset subset: mouse_subset synonym: "SN SEMA5A GABA" EXACT [] is_a: CL:0011005 ! GABAergic interneuron property_value: CLM:0010001 DHBA:10333 {CLM:0010002="0.3", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF broad region."} property_value: CLM:0010001 DHBA:10466 {CLM:0010002="0.1", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF broad region."} property_value: CLM:0010001 DHBA:12251 {CLM:0010002="0.1", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF broad region."} property_value: IAO:0000028 "SN SEMA5A GABA (Primate)" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#AQQBTlhKOU5aQVFBNU1FSFFOT1dKUQACVEdCUTJGRVYyN04wQ1BMS1ZBWgADBQFFM0hHQllIUkM5OEdBNkZXOUY2AAIAAAEzWEJPRkJSMzAyRVlDMFVRRDUxAAIAAAFTUTZXSk8wR05VSkdGVThMSFZWAAIAAAFISzE0TzFBU0FOUFlIT05GTExRAAIBU04gU0VNQTVBIEdBQkEAAAE2RVdCU0VKNFlGVkdLSTJBUEJMAAIAAAQBAAKEykWZhH5WhgOFDHL%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%2FlmIhY7XHwOGCqZOhfScqgRXTVA4Tk1KNUQ4WE8xQU9JMUw5AAWEFMQWg4zFUoRiab%2BEtOdLBgAHAAAFAAYBAQJISzE0TzFBU0FOUFlIT05GTExRAAN%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%2BA4Re3WaD6nvJAAUABgEBAkhLMTRPMUFTQU5QWUhPTkZMTFEAA34AAAAEAAAIRlRMQVVPVjZTTEIwNzFTVk5VOQAJUE9aMkhDUEJUNjBEU0RKOFVBNwAKAAsBbm9uZQACbm9uZQADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAACCAA%3D" xsd:string {name="Reference data on Allen Brain Cell Atlas"} property_value: seeAlso "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20250428_NEIGH_0002.h5ad" xsd:string {comment="Warning large data file!", name="h5ad data file for CS20250428_NEIGH_0002"} [Term] id: CL:4310115 name: SN SOX6 Dopa substantia nigra dopaminergic neuron (Primate) def: "A substantia nigra dopaminergic neuron of the Primates brain. These cells are located in the substantia nigra . Reference transcriptomic data for this type can be found in the dataset/taxonomy - HMBA Basal Ganglia Consensus Taxonomy in cell set Group:SN SOX6 Dopa." [https://alleninstitute.github.io/HMBA_BasalGanglia_Consensus_Taxonomy/, https://doi.org/10.1038/s41593-022-01061-1] comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions. {xref="https://doi.org/10.1038/s41593-022-01061-1"} subset: human_subset subset: mouse_subset synonym: "SN SOX6 Dopa" EXACT [] is_a: CL:0000000 ! cell property_value: CLM:0010001 DHBA:12251 {CLM:0010002="0.9", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF broad region."} property_value: CLM:0010003 CLM:5050515 property_value: IAO:0000028 "SN SOX6 Dopa (Primate)" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#AQQBTlhKOU5aQVFBNU1FSFFOT1dKUQACVEdCUTJGRVYyN04wQ1BMS1ZBWgADBQFFM0hHQllIUkM5OEdBNkZXOUY2AAIAAAEzWEJPRkJSMzAyRVlDMFVRRDUxAAIAAAFTUTZXSk8wR05VSkdGVThMSFZWAAIAAAFISzE0TzFBU0FOUFlIT05GTExRAAIBU04gU09YNiBEb3BhAAABNkVXQlNFSjRZRlZHS0kyQVBCTAACAAAEAQAChMpFmYR%2BVoYDhQxy%2FoU8XEUEV01QOE5NSjVEOFhPMUFPSTFMOQAFg2xvMYI24kGDwAnEgzgCUgAFAAYBAQJISzE0TzFBU0FOUFlIT05GTExRAAN%2BAAAABAAACElBNlk2U043UVpTSUVKMEZaMFUACVBPWjJIQ1BCVDYwRFNESjhVQTcACgALATc0MTZCNVhKRFNZMEhERjkzUk8AAkNSRUhSQ0syWVhSV0pLMkowQUwAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAVZNNEU2SjlEUFlZRDdFMEJITkIAAktHWkxBV0lQQ1I0Vzk4RjVMRDYAAwUBRTNIR0JZSFJDOThHQTZGVzlGNgACAAABM1hCT0ZCUjMwMkVZQzBVUUQ1MQACAAABU1E2V0pPMEdOVUpHRlU4TEhWVgACAAABSEsxNE8xQVNBTlBZSE9ORkxMUQACAVNOIFNPWDYgRG9wYQAAATZFV0JTRUo0WUZWR0tJMkFQQkwAAgAABAEAAoX%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%2Bp7yQAFAAYBAQJISzE0TzFBU0FOUFlIT05GTExRAAN%2BAAAABAAACEZUTEFVT1Y2U0xCMDcxU1ZOVTkACVBPWjJIQ1BCVDYwRFNESjhVQTcACgALAW5vbmUAAm5vbmUAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAggA" xsd:string {name="Reference data on Allen Brain Cell Atlas"} property_value: seeAlso "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20250428_NEIGH_0000.h5ad" xsd:string {comment="Warning large data file!", name="h5ad data file for CS20250428_NEIGH_0000"} [Term] id: CL:4310117 name: SN-VTR-HTH GATA3-TCF7L2 GABA GABAergic interneuron (Primate) def: "A GABAergic interneuron of the Primates brain. These cells are located in the substantia nigra . Reference transcriptomic data for this type can be found in the dataset/taxonomy - HMBA Basal Ganglia Consensus Taxonomy in cell set Group:SN-VTR-HTH GATA3-TCF7L2 GABA." [https://alleninstitute.github.io/HMBA_BasalGanglia_Consensus_Taxonomy/] comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions. subset: human_subset subset: mouse_subset synonym: "SN-VTR-HTH GATA3-TCF7L2 GABA" EXACT [] is_a: CL:0011005 ! GABAergic interneuron property_value: CLM:0010001 DHBA:12251 {CLM:0010002="0.5", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF broad region."} property_value: IAO:0000028 "SN-VTR-HTH GATA3-TCF7L2 GABA (Primate)" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#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%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%3D%3D" xsd:string {name="Reference data on Allen Brain Cell Atlas"} property_value: seeAlso "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20250428_NEIGH_0002.h5ad" xsd:string {comment="Warning large data file!", name="h5ad data file for CS20250428_NEIGH_0002"} [Term] id: CL:4310118 name: STH PVALB-PITX2 Glut glutamatergic neuron of the basal ganglia (Primate) def: "A glutamatergic neuron of the basal ganglia of the Primates brain. These cells are located in the subthalamic nucleus . Reference transcriptomic data for this type can be found in the dataset/taxonomy - HMBA Basal Ganglia Consensus Taxonomy in cell set Group:STH PVALB-PITX2 Glut." [https://alleninstitute.github.io/HMBA_BasalGanglia_Consensus_Taxonomy/, https://doi.org/10.1038/s41586-023-06812-z] comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions. {xref="https://doi.org/10.1038/s41586-023-06812-z"} subset: human_subset subset: mouse_subset synonym: "STH PVALB-PITX2 Glut" EXACT [] is_a: CL:4042040 ! glutamatergic neuron of the basal ganglia property_value: CLM:0010001 DHBA:10466 {CLM:0010002="0.9", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF broad region."} property_value: IAO:0000028 "STH PVALB-PITX2 Glut (Primate)" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#AQQBTlhKOU5aQVFBNU1FSFFOT1dKUQACVEdCUTJGRVYyN04wQ1BMS1ZBWgADBQFFM0hHQllIUkM5OEdBNkZXOUY2AAIAAAEzWEJPRkJSMzAyRVlDMFVRRDUxAAIAAAFTUTZXSk8wR05VSkdGVThMSFZWAAIAAAFISzE0TzFBU0FOUFlIT05GTExRAAIBU1RIIFBWQUxCLVBJVFgyIEdsdXQAAAE2RVdCU0VKNFlGVkdLSTJBUEJMAAIAAAQBAAKEykWZhH5WhgOFDHL%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%2FlmIhY7XHwOGCqZOhfScqgRXTVA4Tk1KNUQ4WE8xQU9JMUw5AAWEFMQWg4zFUoRiab%2BEtOdLBgAHAAAFAAYBAQJISzE0TzFBU0FOUFlIT05GTExRAAN%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%2BA4Re3WaD6nvJAAUABgEBAkhLMTRPMUFTQU5QWUhPTkZMTFEAA34AAAAEAAAIRlRMQVVPVjZTTEIwNzFTVk5VOQAJUE9aMkhDUEJUNjBEU0RKOFVBNwAKAAsBbm9uZQACbm9uZQADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAACCAA%3D" xsd:string {name="Reference data on Allen Brain Cell Atlas"} property_value: seeAlso "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20250428_NEIGH_0000.h5ad" xsd:string {comment="Warning large data file!", name="h5ad data file for CS20250428_NEIGH_0000"} [Term] id: CL:4310120 name: striatal pthlh-expressing interneuron (Primate) def: "A striatal pthlh-expressing interneuron of the Primates brain. These cells are located in the striatum . Reference transcriptomic data for this type can be found in the dataset/taxonomy - HMBA Basal Ganglia Consensus Taxonomy in cell set Group:STR FS PTHLH-PVALB GABA." [https://alleninstitute.github.io/HMBA_BasalGanglia_Consensus_Taxonomy/, https://doi.org/10.1016/j.celrep.2018.07.053] comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions. {xref="https://doi.org/10.1016/j.celrep.2018.07.053"} subset: human_subset subset: mouse_subset synonym: "FS" EXACT [] synonym: "Pvalb Pthlh" EXACT [] synonym: "STR FS PTHLH-PVALB GABA" EXACT [] is_a: CL:4042023 ! striatal pthlh-expressing interneuron property_value: CLM:0010001 DHBA:10333 {CLM:0010002="0.9", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF broad region."} property_value: CLM:0010003 CLM:5050520 property_value: IAO:0000028 "STR FS PTHLH-PVALB GABA (Primate)" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#AQQBTlhKOU5aQVFBNU1FSFFOT1dKUQACVEdCUTJGRVYyN04wQ1BMS1ZBWgADBQFFM0hHQllIUkM5OEdBNkZXOUY2AAIAAAEzWEJPRkJSMzAyRVlDMFVRRDUxAAIAAAFTUTZXSk8wR05VSkdGVThMSFZWAAIAAAFISzE0TzFBU0FOUFlIT05GTExRAAIBU1RSIEZTIFBUSExILVBWQUxCIEdBQkEAAAE2RVdCU0VKNFlGVkdLSTJBUEJMAAIAAAQBAAKEykWZhH5WhgOFDHL%2BhTxcRQRXTVA4Tk1KNUQ4WE8xQU9JMUw5AAWDbG8xgjbiQYPACcSDOAJSAAUABgEBAkhLMTRPMUFTQU5QWUhPTkZMTFEAA34AAAAEAAAISUE2WTZTTjdRWlNJRUowRlowVQAJUE9aMkhDUEJUNjBEU0RKOFVBNwAKAAsBNzQxNkI1WEpEU1kwSERGOTNSTwACQ1JFSFJDSzJZWFJXSksySjBBTAADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAABVk00RTZKOURQWVlEN0UwQkhOQgACS0daTEFXSVBDUjRXOThGNUxENgADBQFFM0hHQllIUkM5OEdBNkZXOUY2AAIAAAEzWEJPRkJSMzAyRVlDMFVRRDUxAAIAAAFTUTZXSk8wR05VSkdGVThMSFZWAAIAAAFISzE0TzFBU0FOUFlIT05GTExRAAIBU1RSIEZTIFBUSExILVBWQUxCIEdBQkEAAAE2RVdCU0VKNFlGVkdLSTJBUEJMAAIAAAQBAAKF%2FlmIhY7XHwOGCqZOhfScqgRXTVA4Tk1KNUQ4WE8xQU9JMUw5AAWEFMQWg4zFUoRiab%2BEtOdLBgAHAAAFAAYBAQJISzE0TzFBU0FOUFlIT05GTExRAAN%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%2BA4Re3WaD6nvJAAUABgEBAkhLMTRPMUFTQU5QWUhPTkZMTFEAA34AAAAEAAAIRlRMQVVPVjZTTEIwNzFTVk5VOQAJUE9aMkhDUEJUNjBEU0RKOFVBNwAKAAsBbm9uZQACbm9uZQADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAACCAA%3D" xsd:string {name="Reference data on Allen Brain Cell Atlas"} property_value: seeAlso "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20250428_NEIGH_0002.h5ad" xsd:string {comment="Warning large data file!", name="h5ad data file for CS20250428_NEIGH_0002"} [Term] id: CL:4310121 name: striatal SST-LYPD6-RSPO2 GABAergic interneuron (Primate) def: "A GABAergic interneuron of the Primates brain. These cells are located in the striatum . Reference transcriptomic data for this type can be found in the dataset/taxonomy - HMBA Basal Ganglia Consensus Taxonomy in cell set Group:STR LYPD6-RSPO2 GABA." [https://alleninstitute.github.io/HMBA_BasalGanglia_Consensus_Taxonomy/] comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions. subset: human_subset subset: mouse_subset synonym: "STR LYPD6-RSPO2 GABA" EXACT [] is_a: CL:0011005 ! GABAergic interneuron property_value: CLM:0010001 DHBA:10333 {CLM:0010002="0.3", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF broad region."} property_value: IAO:0000028 "STR LYPD6-RSPO2 GABA (Primate)" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#AQQBTlhKOU5aQVFBNU1FSFFOT1dKUQACVEdCUTJGRVYyN04wQ1BMS1ZBWgADBQFFM0hHQllIUkM5OEdBNkZXOUY2AAIAAAEzWEJPRkJSMzAyRVlDMFVRRDUxAAIAAAFTUTZXSk8wR05VSkdGVThMSFZWAAIAAAFISzE0TzFBU0FOUFlIT05GTExRAAIBU1RSIExZUEQ2LVJTUE8yIEdBQkEAAAE2RVdCU0VKNFlGVkdLSTJBUEJMAAIAAAQBAAKEykWZhH5WhgOFDHL%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%2FlmIhY7XHwOGCqZOhfScqgRXTVA4Tk1KNUQ4WE8xQU9JMUw5AAWEFMQWg4zFUoRiab%2BEtOdLBgAHAAAFAAYBAQJISzE0TzFBU0FOUFlIT05GTExRAAN%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%2BA4Re3WaD6nvJAAUABgEBAkhLMTRPMUFTQU5QWUhPTkZMTFEAA34AAAAEAAAIRlRMQVVPVjZTTEIwNzFTVk5VOQAJUE9aMkhDUEJUNjBEU0RKOFVBNwAKAAsBbm9uZQACbm9uZQADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAACCAA%3D" xsd:string {name="Reference data on Allen Brain Cell Atlas"} property_value: seeAlso "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20250428_NEIGH_0002.h5ad" xsd:string {comment="Warning large data file!", name="h5ad data file for CS20250428_NEIGH_0002"} [Term] id: CL:4310122 name: striatal SST-ADARB2 GABAergic interneuron (Primate) def: "A sst GABAergic interneuron of the Primates brain. These cells are located in the striatum . Reference transcriptomic data for this type can be found in the dataset/taxonomy - HMBA Basal Ganglia Consensus Taxonomy in cell set Group:STR SST-ADARB2 GABA." [https://alleninstitute.github.io/HMBA_BasalGanglia_Consensus_Taxonomy/] comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions. subset: human_subset subset: mouse_subset synonym: "STR SST GABA" EXACT [] synonym: "STR SST-ADARB2 GABA" EXACT [] is_a: CL:4023017 ! sst GABAergic interneuron property_value: CLM:0010001 DHBA:10333 {CLM:0010002="0.1", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF broad region."} property_value: IAO:0000028 "STR SST-ADARB2 GABA (Primate)" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#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%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%3D%3D" xsd:string {name="Reference data on Allen Brain Cell Atlas"} property_value: seeAlso "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20250428_NEIGH_0002.h5ad" xsd:string {comment="Warning large data file!", name="h5ad data file for CS20250428_NEIGH_0002"} [Term] id: CL:4310123 name: striatal SST-CHODL GABAergic interneuron (Primate) def: "A sst chodl GABAergic interneuron of the Primates brain. These cells are located in the striatum . Reference transcriptomic data for this type can be found in the dataset/taxonomy - HMBA Basal Ganglia Consensus Taxonomy in cell set Group:STR SST-CHODL GABA." [https://alleninstitute.github.io/HMBA_BasalGanglia_Consensus_Taxonomy/, https://doi.org/10.1038/s41586-020-2874-8] comment: Based on annotation transfer evidence with MapMyCells, this may not represent a transcriptomicallly distinct cell type, but rather the population of SST CHODL GABAergic neurons located in the striatum. Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions. {xref="https://doi.org/10.1038/s41586-020-2874-8"} subset: human_subset subset: mouse_subset synonym: "LTS" EXACT [] synonym: "Sst Chodl" EXACT [] synonym: "STR SST-CHODL GABA" EXACT [] is_a: CL:4023121 ! sst chodl GABAergic interneuron property_value: CLM:0010001 DHBA:10333 {CLM:0010002="0.8", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF broad region."} property_value: CLM:0010003 CLM:5050523 property_value: IAO:0000028 "STR SST-CHODL GABA (Primate)" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#AQQBTlhKOU5aQVFBNU1FSFFOT1dKUQACVEdCUTJGRVYyN04wQ1BMS1ZBWgADBQFFM0hHQllIUkM5OEdBNkZXOUY2AAIAAAEzWEJPRkJSMzAyRVlDMFVRRDUxAAIAAAFTUTZXSk8wR05VSkdGVThMSFZWAAIAAAFISzE0TzFBU0FOUFlIT05GTExRAAIBU1RSIFNTVC1DSE9ETCBHQUJBAAABNkVXQlNFSjRZRlZHS0kyQVBCTAACAAAEAQAChMpFmYR%2BVoYDhQxy%2FoU8XEUEV01QOE5NSjVEOFhPMUFPSTFMOQAFg2xvMYI24kGDwAnEgzgCUgAFAAYBAQJISzE0TzFBU0FOUFlIT05GTExRAAN%2BAAAABAAACElBNlk2U043UVpTSUVKMEZaMFUACVBPWjJIQ1BCVDYwRFNESjhVQTcACgALATc0MTZCNVhKRFNZMEhERjkzUk8AAkNSRUhSQ0syWVhSV0pLMkowQUwAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAVZNNEU2SjlEUFlZRDdFMEJITkIAAktHWkxBV0lQQ1I0Vzk4RjVMRDYAAwUBRTNIR0JZSFJDOThHQTZGVzlGNgACAAABM1hCT0ZCUjMwMkVZQzBVUUQ1MQACAAABU1E2V0pPMEdOVUpHRlU4TEhWVgACAAABSEsxNE8xQVNBTlBZSE9ORkxMUQACAVNUUiBTU1QtQ0hPREwgR0FCQQAAATZFV0JTRUo0WUZWR0tJMkFQQkwAAgAABAEAAoX%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%2Bp7yQAFAAYBAQJISzE0TzFBU0FOUFlIT05GTExRAAN%2BAAAABAAACEZUTEFVT1Y2U0xCMDcxU1ZOVTkACVBPWjJIQ1BCVDYwRFNESjhVQTcACgALAW5vbmUAAm5vbmUAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAggA" xsd:string {name="Reference data on Allen Brain Cell Atlas"} property_value: seeAlso "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20250428_NEIGH_0002.h5ad" xsd:string {comment="Warning large data file!", name="h5ad data file for CS20250428_NEIGH_0002"} [Term] id: CL:4310124 name: striatal SST-RSPO2 GABAergic interneuron (Primate) def: "A sst GABAergic interneuron of the Primates brain. These cells are located in the striatum . Reference transcriptomic data for this type can be found in the dataset/taxonomy - HMBA Basal Ganglia Consensus Taxonomy in cell set Group:STR SST-RSPO2 GABA." [https://alleninstitute.github.io/HMBA_BasalGanglia_Consensus_Taxonomy/] comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions. subset: human_subset subset: mouse_subset synonym: "STR SST-RSPO2 GABA" EXACT [] is_a: CL:4023017 ! sst GABAergic interneuron property_value: CLM:0010001 DHBA:10333 {CLM:0010002="0.4", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF broad region."} property_value: IAO:0000028 "STR SST-RSPO2 GABA (Primate)" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#AQQBTlhKOU5aQVFBNU1FSFFOT1dKUQACVEdCUTJGRVYyN04wQ1BMS1ZBWgADBQFFM0hHQllIUkM5OEdBNkZXOUY2AAIAAAEzWEJPRkJSMzAyRVlDMFVRRDUxAAIAAAFTUTZXSk8wR05VSkdGVThMSFZWAAIAAAFISzE0TzFBU0FOUFlIT05GTExRAAIBU1RSIFNTVC1SU1BPMiBHQUJBAAABNkVXQlNFSjRZRlZHS0kyQVBCTAACAAAEAQAChMpFmYR%2BVoYDhQxy%2FoU8XEUEV01QOE5NSjVEOFhPMUFPSTFMOQAFg2xvMYI24kGDwAnEgzgCUgAFAAYBAQJISzE0TzFBU0FOUFlIT05GTExRAAN%2BAAAABAAACElBNlk2U043UVpTSUVKMEZaMFUACVBPWjJIQ1BCVDYwRFNESjhVQTcACgALATc0MTZCNVhKRFNZMEhERjkzUk8AAkNSRUhSQ0syWVhSV0pLMkowQUwAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAVZNNEU2SjlEUFlZRDdFMEJITkIAAktHWkxBV0lQQ1I0Vzk4RjVMRDYAAwUBRTNIR0JZSFJDOThHQTZGVzlGNgACAAABM1hCT0ZCUjMwMkVZQzBVUUQ1MQACAAABU1E2V0pPMEdOVUpHRlU4TEhWVgACAAABSEsxNE8xQVNBTlBZSE9ORkxMUQACAVNUUiBTU1QtUlNQTzIgR0FCQQAAATZFV0JTRUo0WUZWR0tJMkFQQkwAAgAABAEAAoX%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%2Bp7yQAFAAYBAQJISzE0TzFBU0FOUFlIT05GTExRAAN%2BAAAABAAACEZUTEFVT1Y2U0xCMDcxU1ZOVTkACVBPWjJIQ1BCVDYwRFNESjhVQTcACgALAW5vbmUAAm5vbmUAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAggA" xsd:string {name="Reference data on Allen Brain Cell Atlas"} property_value: seeAlso "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20250428_NEIGH_0002.h5ad" xsd:string {comment="Warning large data file!", name="h5ad data file for CS20250428_NEIGH_0002"} [Term] id: CL:4310125 name: STR TAC3-PLPP4 GABA TAC3-positive striatal interneuron (Primate) def: "A TAC3-positive striatal interneuron of the Primates brain. These cells are located in the striatum . Reference transcriptomic data for this type can be found in the dataset/taxonomy - HMBA Basal Ganglia Consensus Taxonomy in cell set Group:STR TAC3-PLPP4 GABA." [https://alleninstitute.github.io/HMBA_BasalGanglia_Consensus_Taxonomy/, https://doi.org/10.1038/s41586-020-2874-8] comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions. {xref="https://doi.org/10.1038/s41586-020-2874-8"} subset: human_subset subset: mouse_subset synonym: "LHX6 TAC3" EXACT [] synonym: "STR TAC3-PLPP4 GABA" EXACT [] is_a: CL:4042001 ! TAC3-positive striatal interneuron property_value: CLM:0010001 DHBA:10333 {CLM:0010002="0.9", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF broad region."} property_value: CLM:0010003 CLM:5050525 property_value: IAO:0000028 "STR TAC3-PLPP4 GABA (Primate)" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#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%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%3D%3D" xsd:string {name="Reference data on Allen Brain Cell Atlas"} property_value: seeAlso "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20250428_NEIGH_0002.h5ad" xsd:string {comment="Warning large data file!", name="h5ad data file for CS20250428_NEIGH_0002"} [Term] id: CL:4310126 name: STR-BF TAC3-PLPP4-LHX8 GABA TAC3-positive striatal interneuron (Primate) def: "A TAC3-positive striatal interneuron of the Primates brain. These cells are located in the striatum . Reference transcriptomic data for this type can be found in the dataset/taxonomy - HMBA Basal Ganglia Consensus Taxonomy in cell set Group:STR-BF TAC3-PLPP4-LHX8 GABA." [https://alleninstitute.github.io/HMBA_BasalGanglia_Consensus_Taxonomy/] comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions. subset: human_subset subset: mouse_subset synonym: "STR-BF TAC3-PLPP4-LHX8 GABA" EXACT [] is_a: CL:4042001 ! TAC3-positive striatal interneuron property_value: CLM:0010001 DHBA:10333 {CLM:0010002="0.7", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF broad region."} property_value: IAO:0000028 "STR-BF TAC3-PLPP4-LHX8 GABA (Primate)" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#AQQBTlhKOU5aQVFBNU1FSFFOT1dKUQACVEdCUTJGRVYyN04wQ1BMS1ZBWgADBQFFM0hHQllIUkM5OEdBNkZXOUY2AAIAAAEzWEJPRkJSMzAyRVlDMFVRRDUxAAIAAAFTUTZXSk8wR05VSkdGVThMSFZWAAIAAAFISzE0TzFBU0FOUFlIT05GTExRAAIBU1RSLUJGIFRBQzMtUExQUDQtTEhYOCBHQUJBAAABNkVXQlNFSjRZRlZHS0kyQVBCTAACAAAEAQAChMpFmYR%2BVoYDhQxy%2FoU8XEUEV01QOE5NSjVEOFhPMUFPSTFMOQAFg2xvMYI24kGDwAnEgzgCUgAFAAYBAQJISzE0TzFBU0FOUFlIT05GTExRAAN%2BAAAABAAACElBNlk2U043UVpTSUVKMEZaMFUACVBPWjJIQ1BCVDYwRFNESjhVQTcACgALATc0MTZCNVhKRFNZMEhERjkzUk8AAkNSRUhSQ0syWVhSV0pLMkowQUwAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAVZNNEU2SjlEUFlZRDdFMEJITkIAAktHWkxBV0lQQ1I0Vzk4RjVMRDYAAwUBRTNIR0JZSFJDOThHQTZGVzlGNgACAAABM1hCT0ZCUjMwMkVZQzBVUUQ1MQACAAABU1E2V0pPMEdOVUpHRlU4TEhWVgACAAABSEsxNE8xQVNBTlBZSE9ORkxMUQACAVNUUi1CRiBUQUMzLVBMUFA0LUxIWDggR0FCQQAAATZFV0JTRUo0WUZWR0tJMkFQQkwAAgAABAEAAoX%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%2Bp7yQAFAAYBAQJISzE0TzFBU0FOUFlIT05GTExRAAN%2BAAAABAAACEZUTEFVT1Y2U0xCMDcxU1ZOVTkACVBPWjJIQ1BCVDYwRFNESjhVQTcACgALAW5vbmUAAm5vbmUAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAggA" xsd:string {name="Reference data on Allen Brain Cell Atlas"} property_value: seeAlso "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20250428_NEIGH_0002.h5ad" xsd:string {comment="Warning large data file!", name="h5ad data file for CS20250428_NEIGH_0002"} [Term] id: CL:4310127 name: striatal VIP GABAergic interneuron (Primate) def: "A VIP GABAergic interneuron of the Primates brain. These cells are located in the striatum . Reference transcriptomic data for this type can be found in the dataset/taxonomy - HMBA Basal Ganglia Consensus Taxonomy in cell set Group:VIP GABA." [https://alleninstitute.github.io/HMBA_BasalGanglia_Consensus_Taxonomy/, https://doi.org/10.1038/s41586-020-2874-8] comment: Based on annotation transfer evidence with MapMyCells, this may not represent a transcriptomicallly distinct cell type, but rather the population of VIP GABAergic neurons located in the striatum. Rationale for assigning this type to reference data: Mapping to the general type VIP GABAergic neuron is supported by MapMyCells heirarchical annotation transfer mapping to 046 Vip Gaba in the whole mouse brain taxonomy v1. Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions. {xref="https://doi.org/10.1038/s41586-020-2874-8"} subset: human_subset subset: mouse_subset synonym: "CN VIP GABA" EXACT [] synonym: "VIP" EXACT [] synonym: "VIP GABA" EXACT [] is_a: CL:4023016 ! VIP GABAergic interneuron property_value: CLM:0010001 DHBA:10333 {CLM:0010002="0.5", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF broad region."} property_value: CLM:0010003 CLM:5050527 property_value: IAO:0000028 "VIP GABA (Primate)" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#AQQBTlhKOU5aQVFBNU1FSFFOT1dKUQACVEdCUTJGRVYyN04wQ1BMS1ZBWgADBQFFM0hHQllIUkM5OEdBNkZXOUY2AAIAAAEzWEJPRkJSMzAyRVlDMFVRRDUxAAIAAAFTUTZXSk8wR05VSkdGVThMSFZWAAIAAAFISzE0TzFBU0FOUFlIT05GTExRAAIBVklQIEdBQkEAAAE2RVdCU0VKNFlGVkdLSTJBUEJMAAIAAAQBAAKEykWZhH5WhgOFDHL%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%2FlmIhY7XHwOGCqZOhfScqgRXTVA4Tk1KNUQ4WE8xQU9JMUw5AAWEFMQWg4zFUoRiab%2BEtOdLBgAHAAAFAAYBAQJISzE0TzFBU0FOUFlIT05GTExRAAN%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%2BA4Re3WaD6nvJAAUABgEBAkhLMTRPMUFTQU5QWUhPTkZMTFEAA34AAAAEAAAIRlRMQVVPVjZTTEIwNzFTVk5VOQAJUE9aMkhDUEJUNjBEU0RKOFVBNwAKAAsBbm9uZQACbm9uZQADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAACCAA%3D" xsd:string {name="Reference data on Allen Brain Cell Atlas"} property_value: seeAlso "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20250428_NEIGH_0002.h5ad" xsd:string {comment="Warning large data file!", name="h5ad data file for CS20250428_NEIGH_0002"} [Term] id: CL:4310128 name: STRd cholinergic-GABAergic neuron (Primate) def: "A dorso-striatal cholinergic-GABAergic neuron of the Primates brain. These cells are located in the striatum . Reference transcriptomic data for this type can be found in the dataset/taxonomy - HMBA Basal Ganglia Consensus Taxonomy in cell set Group:STRd Cholinergic GABA." [https://alleninstitute.github.io/HMBA_BasalGanglia_Consensus_Taxonomy/] comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions. subset: human_subset subset: mouse_subset synonym: "STRd Cholinergic GABA" EXACT [] is_a: CL:0020007 ! dorso-striatal cholinergic-GABAergic neuron property_value: CLM:0010001 DHBA:10333 {CLM:0010002="1.0", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF broad region."} property_value: IAO:0000028 "STRd Cholinergic GABA (Primate)" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#AQQBTlhKOU5aQVFBNU1FSFFOT1dKUQACVEdCUTJGRVYyN04wQ1BMS1ZBWgADBQFFM0hHQllIUkM5OEdBNkZXOUY2AAIAAAEzWEJPRkJSMzAyRVlDMFVRRDUxAAIAAAFTUTZXSk8wR05VSkdGVThMSFZWAAIAAAFISzE0TzFBU0FOUFlIT05GTExRAAIBU1RSZCBDaG9saW5lcmdpYyBHQUJBAAABNkVXQlNFSjRZRlZHS0kyQVBCTAACAAAEAQAChMpFmYR%2BVoYDhQxy%2FoU8XEUEV01QOE5NSjVEOFhPMUFPSTFMOQAFg2xvMYI24kGDwAnEgzgCUgAFAAYBAQJISzE0TzFBU0FOUFlIT05GTExRAAN%2BAAAABAAACElBNlk2U043UVpTSUVKMEZaMFUACVBPWjJIQ1BCVDYwRFNESjhVQTcACgALATc0MTZCNVhKRFNZMEhERjkzUk8AAkNSRUhSQ0syWVhSV0pLMkowQUwAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAVZNNEU2SjlEUFlZRDdFMEJITkIAAktHWkxBV0lQQ1I0Vzk4RjVMRDYAAwUBRTNIR0JZSFJDOThHQTZGVzlGNgACAAABM1hCT0ZCUjMwMkVZQzBVUUQ1MQACAAABU1E2V0pPMEdOVUpHRlU4TEhWVgACAAABSEsxNE8xQVNBTlBZSE9ORkxMUQACAVNUUmQgQ2hvbGluZXJnaWMgR0FCQQAAATZFV0JTRUo0WUZWR0tJMkFQQkwAAgAABAEAAoX%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%2Bp7yQAFAAYBAQJISzE0TzFBU0FOUFlIT05GTExRAAN%2BAAAABAAACEZUTEFVT1Y2U0xCMDcxU1ZOVTkACVBPWjJIQ1BCVDYwRFNESjhVQTcACgALAW5vbmUAAm5vbmUAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAggA" xsd:string {name="Reference data on Allen Brain Cell Atlas"} property_value: seeAlso "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20250428_NEIGH_0002.h5ad" xsd:string {comment="Warning large data file!", name="h5ad data file for CS20250428_NEIGH_0002"} [Term] id: CL:4310129 name: STRd D1 Matrix medium spiny neuron (Primate) def: "A matrix D1 medium spiny neuron of the Primates brain. These cells are located in the striatum . Reference transcriptomic data for this type can be found in the dataset/taxonomy - HMBA Basal Ganglia Consensus Taxonomy in cell set Group:STRd D1 Matrix MSN." [https://alleninstitute.github.io/HMBA_BasalGanglia_Consensus_Taxonomy/, https://doi.org/10.1016/j.cub.2021.10.015] comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions. {xref="https://doi.org/10.1016/j.cub.2021.10.015"} subset: human_subset subset: mouse_subset synonym: "D1-Matrix" EXACT [] synonym: "STRd D1 Matrix MSN" EXACT [] is_a: CL:4030043 ! matrix D1 medium spiny neuron property_value: CLM:0010001 DHBA:10333 {CLM:0010002="1.0", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF broad region."} property_value: CLM:0010003 CLM:5050529 property_value: IAO:0000028 "STRd D1 Matrix MSN (Primate)" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#AQQBTlhKOU5aQVFBNU1FSFFOT1dKUQACVEdCUTJGRVYyN04wQ1BMS1ZBWgADBQFFM0hHQllIUkM5OEdBNkZXOUY2AAIAAAEzWEJPRkJSMzAyRVlDMFVRRDUxAAIAAAFTUTZXSk8wR05VSkdGVThMSFZWAAIAAAFISzE0TzFBU0FOUFlIT05GTExRAAIBU1RSZCBEMSBNYXRyaXggTVNOAAABNkVXQlNFSjRZRlZHS0kyQVBCTAACAAAEAQAChMpFmYR%2BVoYDhQxy%2FoU8XEUEV01QOE5NSjVEOFhPMUFPSTFMOQAFg2xvMYI24kGDwAnEgzgCUgAFAAYBAQJISzE0TzFBU0FOUFlIT05GTExRAAN%2BAAAABAAACElBNlk2U043UVpTSUVKMEZaMFUACVBPWjJIQ1BCVDYwRFNESjhVQTcACgALATc0MTZCNVhKRFNZMEhERjkzUk8AAkNSRUhSQ0syWVhSV0pLMkowQUwAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAVZNNEU2SjlEUFlZRDdFMEJITkIAAktHWkxBV0lQQ1I0Vzk4RjVMRDYAAwUBRTNIR0JZSFJDOThHQTZGVzlGNgACAAABM1hCT0ZCUjMwMkVZQzBVUUQ1MQACAAABU1E2V0pPMEdOVUpHRlU4TEhWVgACAAABSEsxNE8xQVNBTlBZSE9ORkxMUQACAVNUUmQgRDEgTWF0cml4IE1TTgAAATZFV0JTRUo0WUZWR0tJMkFQQkwAAgAABAEAAoX%2BWYiFjtcfA4YKpk6F9JyqBFdNUDhOTUo1RDhYTzFBT0kxTDkABYQUxBaDjMVShGJpv4S050sGAAcAAAUABgEBAkhLMTRPMUFTQU5QWUhPTkZMTFEAA34AAAAEAAAIOUFVVEU5UzEwS0FFQzJVWk8zMQAJUE9aMkhDUEJUNjBEU0RKOFVBNwAKAAsBWTNQMUpNMUVOQ0dXRVc4VVNUVgACQ1JFSFJDSzJZWFJXSksySjBBTAADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAABM0NQSVAyODA0U0JEWDFEWDFSVwACUzVLUVRGSENSS0hWWlZSUjVIUgADBQFFM0hHQllIUkM5OEdBNkZXOUY2AAIAAAEzWEJPRkJSMzAyRVlDMFVRRDUxAAIAAAFTUTZXSk8wR05VSkdGVThMSFZWAAIAAAFISzE0TzFBU0FOUFlIT05GTExRAAIBU1RSZCBEMSBNYXRyaXggTVNOAAABNkVXQlNFSjRZRlZHS0kyQVBCTAACAAAEAQAChebihoaWQSADh2hhMoagk4YEV01QOE5NSjVEOFhPMUFPSTFMOQAFgdih64S2EZmE2pRdhQKGhgYABwAABQAGAQECSEsxNE8xQVNBTlBZSE9ORkxMUQADfgAAAAQAAAhIWkVZWFNRT0VETkQyUTZNOTdNAAlQT1oySENQQlQ2MERTREo4VUE3AAoACwE2VDk2MjYwMTI2VFY0S0xHRFhHAAJDUkVIUkNLMllYUldKSzJKMEFMAAMBBAEAAiMwMDAwMDAAA8gBAAUBAQIjMDAwMDAwAAPIAQAAAAFFSVVBTFBZTkdaNVZVN1kyWTAyAAJRWlEyUUJNVTRUNUk0N0QxSzRGAAMFAUUzSEdCWUhSQzk4R0E2Rlc5RjYAAgAAATNYQk9GQlIzMDJFWUMwVVFENTEAAgAAAVNRNldKTzBHTlVKR0ZVOExIVlYAAgAAAUhLMTRPMUFTQU5QWUhPTkZMTFEAAgFTVFJkIEQxIE1hdHJpeCBNU04AAAE2RVdCU0VKNFlGVkdLSTJBUEJMAAIAAAQBAQKBItJbgQi1PgOEXt1mg%2Bp7yQAFAAYBAQJISzE0TzFBU0FOUFlIT05GTExRAAN%2BAAAABAAACEZUTEFVT1Y2U0xCMDcxU1ZOVTkACVBPWjJIQ1BCVDYwRFNESjhVQTcACgALAW5vbmUAAm5vbmUAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAggA" xsd:string {name="Reference data on Allen Brain Cell Atlas"} property_value: seeAlso "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20250428_NEIGH_0002.h5ad" xsd:string {comment="Warning large data file!", name="h5ad data file for CS20250428_NEIGH_0002"} [Term] id: CL:4310130 name: striosomal D1 medium spiny neuron (Primate) def: "A striosomal D1 medium spiny neuron of the Primates brain. These cells are located in the striatum . Reference transcriptomic data for this type can be found in the dataset/taxonomy - HMBA Basal Ganglia Consensus Taxonomy in cell set Group:STRd D1 Striosome MSN." [https://alleninstitute.github.io/HMBA_BasalGanglia_Consensus_Taxonomy/, https://doi.org/10.1016/j.cub.2021.10.015] comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions. {xref="https://doi.org/10.1016/j.cub.2021.10.015"} subset: human_subset subset: mouse_subset synonym: "D1-Striosome" EXACT [] synonym: "STRd D1 Striosome MSN" EXACT [] is_a: CL:4030048 ! striosomal D1 medium spiny neuron property_value: CLM:0010001 DHBA:10333 {CLM:0010002="1.0", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF broad region."} property_value: CLM:0010003 CLM:5050530 property_value: IAO:0000028 "STRd D1 Striosome MSN (Primate)" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#AQQBTlhKOU5aQVFBNU1FSFFOT1dKUQACVEdCUTJGRVYyN04wQ1BMS1ZBWgADBQFFM0hHQllIUkM5OEdBNkZXOUY2AAIAAAEzWEJPRkJSMzAyRVlDMFVRRDUxAAIAAAFTUTZXSk8wR05VSkdGVThMSFZWAAIAAAFISzE0TzFBU0FOUFlIT05GTExRAAIBU1RSZCBEMSBTdHJpb3NvbWUgTVNOAAABNkVXQlNFSjRZRlZHS0kyQVBCTAACAAAEAQAChMpFmYR%2BVoYDhQxy%2FoU8XEUEV01QOE5NSjVEOFhPMUFPSTFMOQAFg2xvMYI24kGDwAnEgzgCUgAFAAYBAQJISzE0TzFBU0FOUFlIT05GTExRAAN%2BAAAABAAACElBNlk2U043UVpTSUVKMEZaMFUACVBPWjJIQ1BCVDYwRFNESjhVQTcACgALATc0MTZCNVhKRFNZMEhERjkzUk8AAkNSRUhSQ0syWVhSV0pLMkowQUwAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAVZNNEU2SjlEUFlZRDdFMEJITkIAAktHWkxBV0lQQ1I0Vzk4RjVMRDYAAwUBRTNIR0JZSFJDOThHQTZGVzlGNgACAAABM1hCT0ZCUjMwMkVZQzBVUUQ1MQACAAABU1E2V0pPMEdOVUpHRlU4TEhWVgACAAABSEsxNE8xQVNBTlBZSE9ORkxMUQACAVNUUmQgRDEgU3RyaW9zb21lIE1TTgAAATZFV0JTRUo0WUZWR0tJMkFQQkwAAgAABAEAAoX%2BWYiFjtcfA4YKpk6F9JyqBFdNUDhOTUo1RDhYTzFBT0kxTDkABYQUxBaDjMVShGJpv4S050sGAAcAAAUABgEBAkhLMTRPMUFTQU5QWUhPTkZMTFEAA34AAAAEAAAIOUFVVEU5UzEwS0FFQzJVWk8zMQAJUE9aMkhDUEJUNjBEU0RKOFVBNwAKAAsBWTNQMUpNMUVOQ0dXRVc4VVNUVgACQ1JFSFJDSzJZWFJXSksySjBBTAADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAABM0NQSVAyODA0U0JEWDFEWDFSVwACUzVLUVRGSENSS0hWWlZSUjVIUgADBQFFM0hHQllIUkM5OEdBNkZXOUY2AAIAAAEzWEJPRkJSMzAyRVlDMFVRRDUxAAIAAAFTUTZXSk8wR05VSkdGVThMSFZWAAIAAAFISzE0TzFBU0FOUFlIT05GTExRAAIBU1RSZCBEMSBTdHJpb3NvbWUgTVNOAAABNkVXQlNFSjRZRlZHS0kyQVBCTAACAAAEAQAChebihoaWQSADh2hhMoagk4YEV01QOE5NSjVEOFhPMUFPSTFMOQAFgdih64S2EZmE2pRdhQKGhgYABwAABQAGAQECSEsxNE8xQVNBTlBZSE9ORkxMUQADfgAAAAQAAAhIWkVZWFNRT0VETkQyUTZNOTdNAAlQT1oySENQQlQ2MERTREo4VUE3AAoACwE2VDk2MjYwMTI2VFY0S0xHRFhHAAJDUkVIUkNLMllYUldKSzJKMEFMAAMBBAEAAiMwMDAwMDAAA8gBAAUBAQIjMDAwMDAwAAPIAQAAAAFFSVVBTFBZTkdaNVZVN1kyWTAyAAJRWlEyUUJNVTRUNUk0N0QxSzRGAAMFAUUzSEdCWUhSQzk4R0E2Rlc5RjYAAgAAATNYQk9GQlIzMDJFWUMwVVFENTEAAgAAAVNRNldKTzBHTlVKR0ZVOExIVlYAAgAAAUhLMTRPMUFTQU5QWUhPTkZMTFEAAgFTVFJkIEQxIFN0cmlvc29tZSBNU04AAAE2RVdCU0VKNFlGVkdLSTJBUEJMAAIAAAQBAQKBItJbgQi1PgOEXt1mg%2Bp7yQAFAAYBAQJISzE0TzFBU0FOUFlIT05GTExRAAN%2BAAAABAAACEZUTEFVT1Y2U0xCMDcxU1ZOVTkACVBPWjJIQ1BCVDYwRFNESjhVQTcACgALAW5vbmUAAm5vbmUAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAggA" xsd:string {name="Reference data on Allen Brain Cell Atlas"} property_value: seeAlso "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20250428_NEIGH_0002.h5ad" xsd:string {comment="Warning large data file!", name="h5ad data file for CS20250428_NEIGH_0002"} [Term] id: CL:4310131 name: STRd D1/D2-hybrid medium spiny neuron (Primate) def: "A D1/D2-hybrid medium spiny neuron of the Primates brain. These cells are located in the striatum . Reference transcriptomic data for this type can be found in the dataset/taxonomy - HMBA Basal Ganglia Consensus Taxonomy in cell set Group:STR D1D2 Hybrid MSN." [https://alleninstitute.github.io/HMBA_BasalGanglia_Consensus_Taxonomy/, https://doi.org/10.1016/j.cub.2021.10.015] comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions. {xref="https://doi.org/10.1016/j.cub.2021.10.015"} subset: human_subset subset: mouse_subset synonym: "D1/D2 Hybrid" EXACT [] synonym: "STR D1D2 Hybrid MSN" EXACT [] is_a: CL:0000000 ! cell property_value: CLM:0010001 DHBA:10333 {CLM:0010002="1.0", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF broad region."} property_value: CLM:0010003 CLM:5050531 property_value: IAO:0000028 "STR D1D2 Hybrid MSN (Primate)" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#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%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%3D%3D" xsd:string {name="Reference data on Allen Brain Cell Atlas"} property_value: seeAlso "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20250428_NEIGH_0002.h5ad" xsd:string {comment="Warning large data file!", name="h5ad data file for CS20250428_NEIGH_0002"} [Term] id: CL:4310132 name: STRd D2 Matrix medium spiny neuron (Primate) def: "A matrix D2 medium spiny neuron of the Primates brain. These cells are located in the striatum . Reference transcriptomic data for this type can be found in the dataset/taxonomy - HMBA Basal Ganglia Consensus Taxonomy in cell set Group:STRd D2 Matrix MSN." [https://alleninstitute.github.io/HMBA_BasalGanglia_Consensus_Taxonomy/, https://doi.org/10.1016/j.cub.2021.10.015] comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions. {xref="https://doi.org/10.1016/j.cub.2021.10.015"} subset: human_subset subset: mouse_subset synonym: "D2-Matrix" EXACT [] synonym: "STRd D2 Matrix MSN" EXACT [] is_a: CL:4030047 ! matrix D2 medium spiny neuron property_value: CLM:0010001 DHBA:10333 {CLM:0010002="1.0", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF broad region."} property_value: CLM:0010003 CLM:5050532 property_value: IAO:0000028 "STRd D2 Matrix MSN (Primate)" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#AQQBTlhKOU5aQVFBNU1FSFFOT1dKUQACVEdCUTJGRVYyN04wQ1BMS1ZBWgADBQFFM0hHQllIUkM5OEdBNkZXOUY2AAIAAAEzWEJPRkJSMzAyRVlDMFVRRDUxAAIAAAFTUTZXSk8wR05VSkdGVThMSFZWAAIAAAFISzE0TzFBU0FOUFlIT05GTExRAAIBU1RSZCBEMiBNYXRyaXggTVNOAAABNkVXQlNFSjRZRlZHS0kyQVBCTAACAAAEAQAChMpFmYR%2BVoYDhQxy%2FoU8XEUEV01QOE5NSjVEOFhPMUFPSTFMOQAFg2xvMYI24kGDwAnEgzgCUgAFAAYBAQJISzE0TzFBU0FOUFlIT05GTExRAAN%2BAAAABAAACElBNlk2U043UVpTSUVKMEZaMFUACVBPWjJIQ1BCVDYwRFNESjhVQTcACgALATc0MTZCNVhKRFNZMEhERjkzUk8AAkNSRUhSQ0syWVhSV0pLMkowQUwAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAVZNNEU2SjlEUFlZRDdFMEJITkIAAktHWkxBV0lQQ1I0Vzk4RjVMRDYAAwUBRTNIR0JZSFJDOThHQTZGVzlGNgACAAABM1hCT0ZCUjMwMkVZQzBVUUQ1MQACAAABU1E2V0pPMEdOVUpHRlU4TEhWVgACAAABSEsxNE8xQVNBTlBZSE9ORkxMUQACAVNUUmQgRDIgTWF0cml4IE1TTgAAATZFV0JTRUo0WUZWR0tJMkFQQkwAAgAABAEAAoX%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%2Bp7yQAFAAYBAQJISzE0TzFBU0FOUFlIT05GTExRAAN%2BAAAABAAACEZUTEFVT1Y2U0xCMDcxU1ZOVTkACVBPWjJIQ1BCVDYwRFNESjhVQTcACgALAW5vbmUAAm5vbmUAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAggA" xsd:string {name="Reference data on Allen Brain Cell Atlas"} property_value: seeAlso "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20250428_NEIGH_0002.h5ad" xsd:string {comment="Warning large data file!", name="h5ad data file for CS20250428_NEIGH_0002"} [Term] id: CL:4310133 name: STRd D2 Striomat hybrid medium spiny neuron (Primate) def: "A indirect pathway medium spiny neuron of the Primates brain. These cells are located in the striatum . Reference transcriptomic data for this type can be found in the dataset/taxonomy - HMBA Basal Ganglia Consensus Taxonomy in cell set Group:STRd D2 StrioMat Hybrid MSN." [https://alleninstitute.github.io/HMBA_BasalGanglia_Consensus_Taxonomy/] comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions. subset: human_subset subset: mouse_subset synonym: "STRd D2 StrioMat Hybrid MSN" EXACT [] is_a: CL:0000000 ! cell property_value: CLM:0010001 DHBA:10333 {CLM:0010002="0.9", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF broad region."} property_value: IAO:0000028 "STRd D2 StrioMat Hybrid MSN (Primate)" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#AQQBTlhKOU5aQVFBNU1FSFFOT1dKUQACVEdCUTJGRVYyN04wQ1BMS1ZBWgADBQFFM0hHQllIUkM5OEdBNkZXOUY2AAIAAAEzWEJPRkJSMzAyRVlDMFVRRDUxAAIAAAFTUTZXSk8wR05VSkdGVThMSFZWAAIAAAFISzE0TzFBU0FOUFlIT05GTExRAAIBU1RSZCBEMiBTdHJpb01hdCBIeWJyaWQgTVNOAAABNkVXQlNFSjRZRlZHS0kyQVBCTAACAAAEAQAChMpFmYR%2BVoYDhQxy%2FoU8XEUEV01QOE5NSjVEOFhPMUFPSTFMOQAFg2xvMYI24kGDwAnEgzgCUgAFAAYBAQJISzE0TzFBU0FOUFlIT05GTExRAAN%2BAAAABAAACElBNlk2U043UVpTSUVKMEZaMFUACVBPWjJIQ1BCVDYwRFNESjhVQTcACgALATc0MTZCNVhKRFNZMEhERjkzUk8AAkNSRUhSQ0syWVhSV0pLMkowQUwAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAVZNNEU2SjlEUFlZRDdFMEJITkIAAktHWkxBV0lQQ1I0Vzk4RjVMRDYAAwUBRTNIR0JZSFJDOThHQTZGVzlGNgACAAABM1hCT0ZCUjMwMkVZQzBVUUQ1MQACAAABU1E2V0pPMEdOVUpHRlU4TEhWVgACAAABSEsxNE8xQVNBTlBZSE9ORkxMUQACAVNUUmQgRDIgU3RyaW9NYXQgSHlicmlkIE1TTgAAATZFV0JTRUo0WUZWR0tJMkFQQkwAAgAABAEAAoX%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%2Bp7yQAFAAYBAQJISzE0TzFBU0FOUFlIT05GTExRAAN%2BAAAABAAACEZUTEFVT1Y2U0xCMDcxU1ZOVTkACVBPWjJIQ1BCVDYwRFNESjhVQTcACgALAW5vbmUAAm5vbmUAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAggA" xsd:string {name="Reference data on Allen Brain Cell Atlas"} property_value: seeAlso "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20250428_NEIGH_0002.h5ad" xsd:string {comment="Warning large data file!", name="h5ad data file for CS20250428_NEIGH_0002"} [Term] id: CL:4310134 name: striosomal D2 medium spiny neuron (Primate) def: "A striosomal D2 medium spiny neuron of the Primates brain. These cells are located in the striatum . Reference transcriptomic data for this type can be found in the dataset/taxonomy - HMBA Basal Ganglia Consensus Taxonomy in cell set Group:STRd D2 Striosome MSN." [https://alleninstitute.github.io/HMBA_BasalGanglia_Consensus_Taxonomy/, https://doi.org/10.1016/j.cub.2021.10.015] comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions. {xref="https://doi.org/10.1016/j.cub.2021.10.015"} subset: human_subset subset: mouse_subset synonym: "D2-Striosome" EXACT [] synonym: "STRd D2 Striosome MSN" EXACT [] is_a: CL:4030049 ! striosomal D2 medium spiny neuron property_value: CLM:0010001 DHBA:10333 {CLM:0010002="1.0", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF broad region."} property_value: CLM:0010003 CLM:5050534 property_value: IAO:0000028 "STRd D2 Striosome MSN (Primate)" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#AQQBTlhKOU5aQVFBNU1FSFFOT1dKUQACVEdCUTJGRVYyN04wQ1BMS1ZBWgADBQFFM0hHQllIUkM5OEdBNkZXOUY2AAIAAAEzWEJPRkJSMzAyRVlDMFVRRDUxAAIAAAFTUTZXSk8wR05VSkdGVThMSFZWAAIAAAFISzE0TzFBU0FOUFlIT05GTExRAAIBU1RSZCBEMiBTdHJpb3NvbWUgTVNOAAABNkVXQlNFSjRZRlZHS0kyQVBCTAACAAAEAQAChMpFmYR%2BVoYDhQxy%2FoU8XEUEV01QOE5NSjVEOFhPMUFPSTFMOQAFg2xvMYI24kGDwAnEgzgCUgAFAAYBAQJISzE0TzFBU0FOUFlIT05GTExRAAN%2BAAAABAAACElBNlk2U043UVpTSUVKMEZaMFUACVBPWjJIQ1BCVDYwRFNESjhVQTcACgALATc0MTZCNVhKRFNZMEhERjkzUk8AAkNSRUhSQ0syWVhSV0pLMkowQUwAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAVZNNEU2SjlEUFlZRDdFMEJITkIAAktHWkxBV0lQQ1I0Vzk4RjVMRDYAAwUBRTNIR0JZSFJDOThHQTZGVzlGNgACAAABM1hCT0ZCUjMwMkVZQzBVUUQ1MQACAAABU1E2V0pPMEdOVUpHRlU4TEhWVgACAAABSEsxNE8xQVNBTlBZSE9ORkxMUQACAVNUUmQgRDIgU3RyaW9zb21lIE1TTgAAATZFV0JTRUo0WUZWR0tJMkFQQkwAAgAABAEAAoX%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%2Bp7yQAFAAYBAQJISzE0TzFBU0FOUFlIT05GTExRAAN%2BAAAABAAACEZUTEFVT1Y2U0xCMDcxU1ZOVTkACVBPWjJIQ1BCVDYwRFNESjhVQTcACgALAW5vbmUAAm5vbmUAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAggA" xsd:string {name="Reference data on Allen Brain Cell Atlas"} property_value: seeAlso "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20250428_NEIGH_0002.h5ad" xsd:string {comment="Warning large data file!", name="h5ad data file for CS20250428_NEIGH_0002"} [Term] id: CL:4310135 name: STR cholinergic-GABAergic neuron (Primate) def: "A striatal cholinergic-GABAergic neuron of the Primates brain. These cells are located in the striatum . Reference transcriptomic data for this type can be found in the dataset/taxonomy - HMBA Basal Ganglia Consensus Taxonomy in cell set Group:STR Cholinergic GABA." [https://alleninstitute.github.io/HMBA_BasalGanglia_Consensus_Taxonomy/] comment: Despite the name, this type is not a parent type to STRd cholinergic-GABAergic neuron (Primate), but is instead a transcriptomically distinct sibling. Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions. subset: human_subset subset: mouse_subset synonym: "STR Cholinergic GABA" EXACT [] is_a: CL:0020008 ! striatal cholinergic-GABAergic neuron property_value: CLM:0010001 DHBA:10333 {CLM:0010002="0.6", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF broad region."} property_value: IAO:0000028 "STR Cholinergic GABA (Primate)" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#AQQBTlhKOU5aQVFBNU1FSFFOT1dKUQACVEdCUTJGRVYyN04wQ1BMS1ZBWgADBQFFM0hHQllIUkM5OEdBNkZXOUY2AAIAAAEzWEJPRkJSMzAyRVlDMFVRRDUxAAIAAAFTUTZXSk8wR05VSkdGVThMSFZWAAIAAAFISzE0TzFBU0FOUFlIT05GTExRAAIBU1RSIENob2xpbmVyZ2ljIEdBQkEAAAE2RVdCU0VKNFlGVkdLSTJBUEJMAAIAAAQBAAKEykWZhH5WhgOFDHL%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%2FlmIhY7XHwOGCqZOhfScqgRXTVA4Tk1KNUQ4WE8xQU9JMUw5AAWEFMQWg4zFUoRiab%2BEtOdLBgAHAAAFAAYBAQJISzE0TzFBU0FOUFlIT05GTExRAAN%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%2BA4Re3WaD6nvJAAUABgEBAkhLMTRPMUFTQU5QWUhPTkZMTFEAA34AAAAEAAAIRlRMQVVPVjZTTEIwNzFTVk5VOQAJUE9aMkhDUEJUNjBEU0RKOFVBNwAKAAsBbm9uZQACbm9uZQADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAACCAA%3D" xsd:string {name="Reference data on Allen Brain Cell Atlas"} property_value: seeAlso "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20250428_NEIGH_0002.h5ad" xsd:string {comment="Warning large data file!", name="h5ad data file for CS20250428_NEIGH_0002"} [Term] id: CL:4310136 name: STRv D1 medium spiny neuron (Primate) def: "A nucleus accumbens shell and olfactory tubercle D1 medium spiny neuron of the Primates brain. These cells are located in the striatum . Reference transcriptomic data for this type can be found in the dataset/taxonomy - HMBA Basal Ganglia Consensus Taxonomy in cell set Group:STRv D1 MSN." [https://alleninstitute.github.io/HMBA_BasalGanglia_Consensus_Taxonomy/, https://doi.org/10.1016/j.cub.2021.10.015] comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions. {xref="https://doi.org/10.1016/j.cub.2021.10.015"} subset: human_subset subset: mouse_subset synonym: "D1-Shell/OT" EXACT [] synonym: "STRv D1 MSN" EXACT [] is_a: CL:4030051 ! nucleus accumbens shell and olfactory tubercle D1 medium spiny neuron property_value: CLM:0010001 DHBA:10333 {CLM:0010002="0.9", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF broad region."} property_value: CLM:0010003 CLM:5050536 property_value: IAO:0000028 "STRv D1 MSN (Primate)" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#AQQBTlhKOU5aQVFBNU1FSFFOT1dKUQACVEdCUTJGRVYyN04wQ1BMS1ZBWgADBQFFM0hHQllIUkM5OEdBNkZXOUY2AAIAAAEzWEJPRkJSMzAyRVlDMFVRRDUxAAIAAAFTUTZXSk8wR05VSkdGVThMSFZWAAIAAAFISzE0TzFBU0FOUFlIT05GTExRAAIBU1RSdiBEMSBNU04AAAE2RVdCU0VKNFlGVkdLSTJBUEJMAAIAAAQBAAKEykWZhH5WhgOFDHL%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%2FlmIhY7XHwOGCqZOhfScqgRXTVA4Tk1KNUQ4WE8xQU9JMUw5AAWEFMQWg4zFUoRiab%2BEtOdLBgAHAAAFAAYBAQJISzE0TzFBU0FOUFlIT05GTExRAAN%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%2BA4Re3WaD6nvJAAUABgEBAkhLMTRPMUFTQU5QWUhPTkZMTFEAA34AAAAEAAAIRlRMQVVPVjZTTEIwNzFTVk5VOQAJUE9aMkhDUEJUNjBEU0RKOFVBNwAKAAsBbm9uZQACbm9uZQADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAACCAA%3D" xsd:string {name="Reference data on Allen Brain Cell Atlas"} property_value: seeAlso "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20250428_NEIGH_0002.h5ad" xsd:string {comment="Warning large data file!", name="h5ad data file for CS20250428_NEIGH_0002"} [Term] id: CL:4310137 name: STRv D1-NUDAP medium spiny neuron (Primate) def: "A D1-NUDAP medium spiny neuron of the Primates brain. These cells are located in the striatum . Reference transcriptomic data for this type can be found in the dataset/taxonomy - HMBA Basal Ganglia Consensus Taxonomy in cell set Group:STRv D1 NUDAP MSN." [https://alleninstitute.github.io/HMBA_BasalGanglia_Consensus_Taxonomy/, https://doi.org/10.1016/j.cub.2021.10.015] comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions. {xref="https://doi.org/10.1016/j.cub.2021.10.015"} subset: human_subset subset: mouse_subset synonym: "D1-NUDAP" EXACT [] synonym: "STRv D1 NUDAP MSN" EXACT [] is_a: CL:4030054 ! D1-NUDAP medium spiny neuron property_value: CLM:0010001 DHBA:10333 {CLM:0010002="0.6", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF broad region."} property_value: CLM:0010003 CLM:5050537 property_value: IAO:0000028 "STRv D1 NUDAP MSN (Primate)" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#AQQBTlhKOU5aQVFBNU1FSFFOT1dKUQACVEdCUTJGRVYyN04wQ1BMS1ZBWgADBQFFM0hHQllIUkM5OEdBNkZXOUY2AAIAAAEzWEJPRkJSMzAyRVlDMFVRRDUxAAIAAAFTUTZXSk8wR05VSkdGVThMSFZWAAIAAAFISzE0TzFBU0FOUFlIT05GTExRAAIBU1RSdiBEMSBOVURBUCBNU04AAAE2RVdCU0VKNFlGVkdLSTJBUEJMAAIAAAQBAAKEykWZhH5WhgOFDHL%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%2FlmIhY7XHwOGCqZOhfScqgRXTVA4Tk1KNUQ4WE8xQU9JMUw5AAWEFMQWg4zFUoRiab%2BEtOdLBgAHAAAFAAYBAQJISzE0TzFBU0FOUFlIT05GTExRAAN%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%2BA4Re3WaD6nvJAAUABgEBAkhLMTRPMUFTQU5QWUhPTkZMTFEAA34AAAAEAAAIRlRMQVVPVjZTTEIwNzFTVk5VOQAJUE9aMkhDUEJUNjBEU0RKOFVBNwAKAAsBbm9uZQACbm9uZQADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAACCAA%3D" xsd:string {name="Reference data on Allen Brain Cell Atlas"} property_value: seeAlso "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20250428_NEIGH_0002.h5ad" xsd:string {comment="Warning large data file!", name="h5ad data file for CS20250428_NEIGH_0002"} [Term] id: CL:4310138 name: STRv D2 medium spiny neuron (Primate) def: "A nucleus accumbens shell and olfactory tubercle D2 medium spiny neuron of the Primates brain. These cells are located in the striatum . Reference transcriptomic data for this type can be found in the dataset/taxonomy - HMBA Basal Ganglia Consensus Taxonomy in cell set Group:STRv D2 MSN." [https://alleninstitute.github.io/HMBA_BasalGanglia_Consensus_Taxonomy/, https://doi.org/10.1016/j.cub.2021.10.015] comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions. {xref="https://doi.org/10.1016/j.cub.2021.10.015"} subset: human_subset subset: mouse_subset synonym: "D2-Shell/OT" EXACT [] synonym: "STRv D2 MSN" EXACT [] is_a: CL:4030052 ! nucleus accumbens shell and olfactory tubercle D2 medium spiny neuron property_value: CLM:0010001 DHBA:10333 {CLM:0010002="0.8", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF broad region."} property_value: CLM:0010003 CLM:5050538 property_value: IAO:0000028 "STRv D2 MSN (Primate)" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#AQQBTlhKOU5aQVFBNU1FSFFOT1dKUQACVEdCUTJGRVYyN04wQ1BMS1ZBWgADBQFFM0hHQllIUkM5OEdBNkZXOUY2AAIAAAEzWEJPRkJSMzAyRVlDMFVRRDUxAAIAAAFTUTZXSk8wR05VSkdGVThMSFZWAAIAAAFISzE0TzFBU0FOUFlIT05GTExRAAIBU1RSdiBEMiBNU04AAAE2RVdCU0VKNFlGVkdLSTJBUEJMAAIAAAQBAAKEykWZhH5WhgOFDHL%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%2FlmIhY7XHwOGCqZOhfScqgRXTVA4Tk1KNUQ4WE8xQU9JMUw5AAWEFMQWg4zFUoRiab%2BEtOdLBgAHAAAFAAYBAQJISzE0TzFBU0FOUFlIT05GTExRAAN%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%2BA4Re3WaD6nvJAAUABgEBAkhLMTRPMUFTQU5QWUhPTkZMTFEAA34AAAAEAAAIRlRMQVVPVjZTTEIwNzFTVk5VOQAJUE9aMkhDUEJUNjBEU0RKOFVBNwAKAAsBbm9uZQACbm9uZQADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAACCAA%3D" xsd:string {name="Reference data on Allen Brain Cell Atlas"} property_value: seeAlso "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20250428_NEIGH_0002.h5ad" xsd:string {comment="Warning large data file!", name="h5ad data file for CS20250428_NEIGH_0002"} [Term] id: CL:4310143 name: ZI-HTH GABA GABAergic interneuron (Primate) def: "A GABAergic interneuron of the Primates brain. These cells are located in the substantia nigra . Reference transcriptomic data for this type can be found in the dataset/taxonomy - HMBA Basal Ganglia Consensus Taxonomy in cell set Group:ZI-HTH GABA." [https://alleninstitute.github.io/HMBA_BasalGanglia_Consensus_Taxonomy/] comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions. subset: human_subset subset: mouse_subset synonym: "ZI-HTH GABA" EXACT [] is_a: CL:0011005 ! GABAergic interneuron property_value: CLM:0010001 DHBA:12251 {CLM:0010002="0.5", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF broad region."} property_value: IAO:0000028 "ZI-HTH GABA (Primate)" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#AQQBTlhKOU5aQVFBNU1FSFFOT1dKUQACVEdCUTJGRVYyN04wQ1BMS1ZBWgADBQFFM0hHQllIUkM5OEdBNkZXOUY2AAIAAAEzWEJPRkJSMzAyRVlDMFVRRDUxAAIAAAFTUTZXSk8wR05VSkdGVThMSFZWAAIAAAFISzE0TzFBU0FOUFlIT05GTExRAAIBWkktSFRIIEdBQkEAAAE2RVdCU0VKNFlGVkdLSTJBUEJMAAIAAAQBAAKEykWZhH5WhgOFDHL%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%2FlmIhY7XHwOGCqZOhfScqgRXTVA4Tk1KNUQ4WE8xQU9JMUw5AAWEFMQWg4zFUoRiab%2BEtOdLBgAHAAAFAAYBAQJISzE0TzFBU0FOUFlIT05GTExRAAN%2BAAAABAAACDlBVVRFOVMxMEtBRUMyVVpPMzEACVBPWjJIQ1BCVDYwRFNESjhVQTcACgALAVkzUDFKTTFFTkNHV0VXOFVTVFYAAkNSRUhSQ0syWVhSV0pLMkowQUwAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAATNDUElQMjgwNFNCRFgxRFgxUlcAAlM1S1FURkhDUktIVlpWUlI1SFIAAwUBRTNIR0JZSFJDOThHQTZGVzlGNgACAAABM1hCT0ZCUjMwMkVZQzBVUUQ1MQACAAABU1E2V0pPMEdOVUpHRlU4TEhWVgACAAABSEsxNE8xQVNBTlBZSE9ORkxMUQACAVpJLUhUSCBHQUJBAAABNkVXQlNFSjRZRlZHS0kyQVBCTAACAAAEAQAChebihoaWQSADh2hhMoagk4YEV01QOE5NSjVEOFhPMUFPSTFMOQAFgdih64S2EZmE2pRdhQKGhgYABwAABQAGAQECSEsxNE8xQVNBTlBZSE9ORkxMUQADfgAAAAQAAAhIWkVZWFNRT0VETkQyUTZNOTdNAAlQT1oySENQQlQ2MERTREo4VUE3AAoACwE2VDk2MjYwMTI2VFY0S0xHRFhHAAJDUkVIUkNLMllYUldKSzJKMEFMAAMBBAEAAiMwMDAwMDAAA8gBAAUBAQIjMDAwMDAwAAPIAQAAAAFFSVVBTFBZTkdaNVZVN1kyWTAyAAJRWlEyUUJNVTRUNUk0N0QxSzRGAAMFAUUzSEdCWUhSQzk4R0E2Rlc5RjYAAgAAATNYQk9GQlIzMDJFWUMwVVFENTEAAgAAAVNRNldKTzBHTlVKR0ZVOExIVlYAAgAAAUhLMTRPMUFTQU5QWUhPTkZMTFEAAgFaSS1IVEggR0FCQQAAATZFV0JTRUo0WUZWR0tJMkFQQkwAAgAABAEBAoEi0luBCLU%2BA4Re3WaD6nvJAAUABgEBAkhLMTRPMUFTQU5QWUhPTkZMTFEAA34AAAAEAAAIRlRMQVVPVjZTTEIwNzFTVk5VOQAJUE9aMkhDUEJUNjBEU0RKOFVBNwAKAAsBbm9uZQACbm9uZQADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAACCAA%3D" xsd:string {name="Reference data on Allen Brain Cell Atlas"} property_value: seeAlso "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20250428_NEIGH_0002.h5ad" xsd:string {comment="Warning large data file!", name="h5ad data file for CS20250428_NEIGH_0002"} [Term] id: CL:4310144 name: VTR-HTH Glut glutamatergic neuron of the basal ganglia (Primate) def: "A glutamatergic neuron of the basal ganglia of the Primates brain. These cells are located in the striatum, subthalamic nucleus, substantia nigra . Reference transcriptomic data for this type can be found in the dataset/taxonomy - HMBA Basal Ganglia Consensus Taxonomy in cell set Group:VTR-HTH Glut." [https://alleninstitute.github.io/HMBA_BasalGanglia_Consensus_Taxonomy/] comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions. subset: human_subset subset: mouse_subset synonym: "F M Glut" EXACT [] synonym: "VTR-HTH Glut" EXACT [] is_a: CL:4042040 ! glutamatergic neuron of the basal ganglia property_value: CLM:0010001 DHBA:10333 {CLM:0010002="0.1", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF broad region."} property_value: CLM:0010001 DHBA:10466 {CLM:0010002="0.1", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF broad region."} property_value: CLM:0010001 DHBA:12251 {CLM:0010002="0.2", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF broad region."} property_value: CLM:0010003 CLM:5050544 property_value: IAO:0000028 "VTR-HTH Glut (Primate)" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#AQQBTlhKOU5aQVFBNU1FSFFOT1dKUQACVEdCUTJGRVYyN04wQ1BMS1ZBWgADBQFFM0hHQllIUkM5OEdBNkZXOUY2AAIAAAEzWEJPRkJSMzAyRVlDMFVRRDUxAAIAAAFTUTZXSk8wR05VSkdGVThMSFZWAAIAAAFISzE0TzFBU0FOUFlIT05GTExRAAIBVlRSLUhUSCBHbHV0AAABNkVXQlNFSjRZRlZHS0kyQVBCTAACAAAEAQAChMpFmYR%2BVoYDhQxy%2FoU8XEUEV01QOE5NSjVEOFhPMUFPSTFMOQAFg2xvMYI24kGDwAnEgzgCUgAFAAYBAQJISzE0TzFBU0FOUFlIT05GTExRAAN%2BAAAABAAACElBNlk2U043UVpTSUVKMEZaMFUACVBPWjJIQ1BCVDYwRFNESjhVQTcACgALATc0MTZCNVhKRFNZMEhERjkzUk8AAkNSRUhSQ0syWVhSV0pLMkowQUwAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAVZNNEU2SjlEUFlZRDdFMEJITkIAAktHWkxBV0lQQ1I0Vzk4RjVMRDYAAwUBRTNIR0JZSFJDOThHQTZGVzlGNgACAAABM1hCT0ZCUjMwMkVZQzBVUUQ1MQACAAABU1E2V0pPMEdOVUpHRlU4TEhWVgACAAABSEsxNE8xQVNBTlBZSE9ORkxMUQACAVZUUi1IVEggR2x1dAAAATZFV0JTRUo0WUZWR0tJMkFQQkwAAgAABAEAAoX%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%2Bp7yQAFAAYBAQJISzE0TzFBU0FOUFlIT05GTExRAAN%2BAAAABAAACEZUTEFVT1Y2U0xCMDcxU1ZOVTkACVBPWjJIQ1BCVDYwRFNESjhVQTcACgALAW5vbmUAAm5vbmUAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAggA" xsd:string {name="Reference data on Allen Brain Cell Atlas"} property_value: seeAlso "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20250428_NEIGH_0000.h5ad" xsd:string {comment="Warning large data file!", name="h5ad data file for CS20250428_NEIGH_0000"} [Term] id: CL:4310145 name: AMY-SLEA-BNST D1 GABA GABAergic interneuron (Primate) def: "A GABAergic interneuron of the Primates brain. These cells are located in the striatum . Reference transcriptomic data for this type can be found in the dataset/taxonomy - HMBA Basal Ganglia Consensus Taxonomy in cell set Group:AMY-SLEA-BNST D1 GABA." [https://alleninstitute.github.io/HMBA_BasalGanglia_Consensus_Taxonomy/] comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions. subset: human_subset subset: mouse_subset synonym: "AMY-SLEA-BNST D1 GABA" EXACT [] is_a: CL:0011005 ! GABAergic interneuron property_value: CLM:0010001 DHBA:10333 {CLM:0010002="0.4", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF broad region."} property_value: IAO:0000028 "AMY-SLEA-BNST D1 GABA (Primate)" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#AQQBTlhKOU5aQVFBNU1FSFFOT1dKUQACVEdCUTJGRVYyN04wQ1BMS1ZBWgADBQFFM0hHQllIUkM5OEdBNkZXOUY2AAIAAAEzWEJPRkJSMzAyRVlDMFVRRDUxAAIAAAFTUTZXSk8wR05VSkdGVThMSFZWAAIAAAFISzE0TzFBU0FOUFlIT05GTExRAAIBQU1ZLVNMRUEtQk5TVCBEMSBHQUJBAAABNkVXQlNFSjRZRlZHS0kyQVBCTAACAAAEAQAChMpFmYR%2BVoYDhQxy%2FoU8XEUEV01QOE5NSjVEOFhPMUFPSTFMOQAFg2xvMYI24kGDwAnEgzgCUgAFAAYBAQJISzE0TzFBU0FOUFlIT05GTExRAAN%2BAAAABAAACElBNlk2U043UVpTSUVKMEZaMFUACVBPWjJIQ1BCVDYwRFNESjhVQTcACgALATc0MTZCNVhKRFNZMEhERjkzUk8AAkNSRUhSQ0syWVhSV0pLMkowQUwAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAVZNNEU2SjlEUFlZRDdFMEJITkIAAktHWkxBV0lQQ1I0Vzk4RjVMRDYAAwUBRTNIR0JZSFJDOThHQTZGVzlGNgACAAABM1hCT0ZCUjMwMkVZQzBVUUQ1MQACAAABU1E2V0pPMEdOVUpHRlU4TEhWVgACAAABSEsxNE8xQVNBTlBZSE9ORkxMUQACAUFNWS1TTEVBLUJOU1QgRDEgR0FCQQAAATZFV0JTRUo0WUZWR0tJMkFQQkwAAgAABAEAAoX%2BWYiFjtcfA4YKpk6F9JyqBFdNUDhOTUo1RDhYTzFBT0kxTDkABYQUxBaDjMVShGJpv4S050sGAAcAAAUABgEBAkhLMTRPMUFTQU5QWUhPTkZMTFEAA34AAAAEAAAIOUFVVEU5UzEwS0FFQzJVWk8zMQAJUE9aMkhDUEJUNjBEU0RKOFVBNwAKAAsBWTNQMUpNMUVOQ0dXRVc4VVNUVgACQ1JFSFJDSzJZWFJXSksySjBBTAADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAABM0NQSVAyODA0U0JEWDFEWDFSVwACUzVLUVRGSENSS0hWWlZSUjVIUgADBQFFM0hHQllIUkM5OEdBNkZXOUY2AAIAAAEzWEJPRkJSMzAyRVlDMFVRRDUxAAIAAAFTUTZXSk8wR05VSkdGVThMSFZWAAIAAAFISzE0TzFBU0FOUFlIT05GTExRAAIBQU1ZLVNMRUEtQk5TVCBEMSBHQUJBAAABNkVXQlNFSjRZRlZHS0kyQVBCTAACAAAEAQAChebihoaWQSADh2hhMoagk4YEV01QOE5NSjVEOFhPMUFPSTFMOQAFgdih64S2EZmE2pRdhQKGhgYABwAABQAGAQECSEsxNE8xQVNBTlBZSE9ORkxMUQADfgAAAAQAAAhIWkVZWFNRT0VETkQyUTZNOTdNAAlQT1oySENQQlQ2MERTREo4VUE3AAoACwE2VDk2MjYwMTI2VFY0S0xHRFhHAAJDUkVIUkNLMllYUldKSzJKMEFMAAMBBAEAAiMwMDAwMDAAA8gBAAUBAQIjMDAwMDAwAAPIAQAAAAFFSVVBTFBZTkdaNVZVN1kyWTAyAAJRWlEyUUJNVTRUNUk0N0QxSzRGAAMFAUUzSEdCWUhSQzk4R0E2Rlc5RjYAAgAAATNYQk9GQlIzMDJFWUMwVVFENTEAAgAAAVNRNldKTzBHTlVKR0ZVOExIVlYAAgAAAUhLMTRPMUFTQU5QWUhPTkZMTFEAAgFBTVktU0xFQS1CTlNUIEQxIEdBQkEAAAE2RVdCU0VKNFlGVkdLSTJBUEJMAAIAAAQBAQKBItJbgQi1PgOEXt1mg%2Bp7yQAFAAYBAQJISzE0TzFBU0FOUFlIT05GTExRAAN%2BAAAABAAACEZUTEFVT1Y2U0xCMDcxU1ZOVTkACVBPWjJIQ1BCVDYwRFNESjhVQTcACgALAW5vbmUAAm5vbmUAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAggA" xsd:string {name="Reference data on Allen Brain Cell Atlas"} property_value: seeAlso "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20250428_NEIGH_0002.h5ad" xsd:string {comment="Warning large data file!", name="h5ad data file for CS20250428_NEIGH_0002"} [Term] id: CL:4310146 name: AMY-SLEA-BNST GABA GABAergic interneuron (Primate) def: "A GABAergic interneuron of the Primates brain. These cells are located in the striatum . Reference transcriptomic data for this type can be found in the dataset/taxonomy - HMBA Basal Ganglia Consensus Taxonomy in cell set Group:AMY-SLEA-BNST GABA." [https://alleninstitute.github.io/HMBA_BasalGanglia_Consensus_Taxonomy/] comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions. subset: human_subset subset: mouse_subset synonym: "AMY-SLEA-BNST GABA" EXACT [] is_a: CL:0011005 ! GABAergic interneuron property_value: CLM:0010001 DHBA:10333 {CLM:0010002="0.1", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF broad region."} property_value: IAO:0000028 "AMY-SLEA-BNST GABA (Primate)" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#AQQBTlhKOU5aQVFBNU1FSFFOT1dKUQACVEdCUTJGRVYyN04wQ1BMS1ZBWgADBQFFM0hHQllIUkM5OEdBNkZXOUY2AAIAAAEzWEJPRkJSMzAyRVlDMFVRRDUxAAIAAAFTUTZXSk8wR05VSkdGVThMSFZWAAIAAAFISzE0TzFBU0FOUFlIT05GTExRAAIBQU1ZLVNMRUEtQk5TVCBHQUJBAAABNkVXQlNFSjRZRlZHS0kyQVBCTAACAAAEAQAChMpFmYR%2BVoYDhQxy%2FoU8XEUEV01QOE5NSjVEOFhPMUFPSTFMOQAFg2xvMYI24kGDwAnEgzgCUgAFAAYBAQJISzE0TzFBU0FOUFlIT05GTExRAAN%2BAAAABAAACElBNlk2U043UVpTSUVKMEZaMFUACVBPWjJIQ1BCVDYwRFNESjhVQTcACgALATc0MTZCNVhKRFNZMEhERjkzUk8AAkNSRUhSQ0syWVhSV0pLMkowQUwAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAVZNNEU2SjlEUFlZRDdFMEJITkIAAktHWkxBV0lQQ1I0Vzk4RjVMRDYAAwUBRTNIR0JZSFJDOThHQTZGVzlGNgACAAABM1hCT0ZCUjMwMkVZQzBVUUQ1MQACAAABU1E2V0pPMEdOVUpHRlU4TEhWVgACAAABSEsxNE8xQVNBTlBZSE9ORkxMUQACAUFNWS1TTEVBLUJOU1QgR0FCQQAAATZFV0JTRUo0WUZWR0tJMkFQQkwAAgAABAEAAoX%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%2Bp7yQAFAAYBAQJISzE0TzFBU0FOUFlIT05GTExRAAN%2BAAAABAAACEZUTEFVT1Y2U0xCMDcxU1ZOVTkACVBPWjJIQ1BCVDYwRFNESjhVQTcACgALAW5vbmUAAm5vbmUAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAggA" xsd:string {name="Reference data on Allen Brain Cell Atlas"} property_value: seeAlso "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20250428_NEIGH_0002.h5ad" xsd:string {comment="Warning large data file!", name="h5ad data file for CS20250428_NEIGH_0002"} [Term] id: CL:4310147 name: OB Dopa-GABA neuron (Primate) def: "A OB-Dopa-GABA of the Primates brain. These cells are located in the striatum . Reference transcriptomic data for this type can be found in the dataset/taxonomy - HMBA Basal Ganglia Consensus Taxonomy in cell set Group:OB Dopa-GABA." [https://alleninstitute.github.io/HMBA_BasalGanglia_Consensus_Taxonomy/] comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions. subset: human_subset subset: mouse_subset synonym: "OB Dopa-GABA" EXACT [] is_a: CL:0020006 ! OB-Dopa-GABA property_value: CLM:0010001 DHBA:10333 {CLM:0010002="0.5", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF broad region."} property_value: IAO:0000028 "OB Dopa-GABA (Primate)" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#AQQBTlhKOU5aQVFBNU1FSFFOT1dKUQACVEdCUTJGRVYyN04wQ1BMS1ZBWgADBQFFM0hHQllIUkM5OEdBNkZXOUY2AAIAAAEzWEJPRkJSMzAyRVlDMFVRRDUxAAIAAAFTUTZXSk8wR05VSkdGVThMSFZWAAIAAAFISzE0TzFBU0FOUFlIT05GTExRAAIBT0IgRG9wYS1HQUJBAAABNkVXQlNFSjRZRlZHS0kyQVBCTAACAAAEAQAChMpFmYR%2BVoYDhQxy%2FoU8XEUEV01QOE5NSjVEOFhPMUFPSTFMOQAFg2xvMYI24kGDwAnEgzgCUgAFAAYBAQJISzE0TzFBU0FOUFlIT05GTExRAAN%2BAAAABAAACElBNlk2U043UVpTSUVKMEZaMFUACVBPWjJIQ1BCVDYwRFNESjhVQTcACgALATc0MTZCNVhKRFNZMEhERjkzUk8AAkNSRUhSQ0syWVhSV0pLMkowQUwAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAVZNNEU2SjlEUFlZRDdFMEJITkIAAktHWkxBV0lQQ1I0Vzk4RjVMRDYAAwUBRTNIR0JZSFJDOThHQTZGVzlGNgACAAABM1hCT0ZCUjMwMkVZQzBVUUQ1MQACAAABU1E2V0pPMEdOVUpHRlU4TEhWVgACAAABSEsxNE8xQVNBTlBZSE9ORkxMUQACAU9CIERvcGEtR0FCQQAAATZFV0JTRUo0WUZWR0tJMkFQQkwAAgAABAEAAoX%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%2Bp7yQAFAAYBAQJISzE0TzFBU0FOUFlIT05GTExRAAN%2BAAAABAAACEZUTEFVT1Y2U0xCMDcxU1ZOVTkACVBPWjJIQ1BCVDYwRFNESjhVQTcACgALAW5vbmUAAm5vbmUAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAggA" xsd:string {name="Reference data on Allen Brain Cell Atlas"} property_value: seeAlso "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20250428_NEIGH_0002.h5ad" xsd:string {comment="Warning large data file!", name="h5ad data file for CS20250428_NEIGH_0002"} [Term] id: CL:4310148 name: OB FRMD7 GABA GABAergic neuron (Primate) def: "A GABAergic neuron of the Primates brain. These cells are located in the striatum . Reference transcriptomic data for this type can be found in the dataset/taxonomy - HMBA Basal Ganglia Consensus Taxonomy in cell set Group:OB FRMD7 GABA." [https://alleninstitute.github.io/HMBA_BasalGanglia_Consensus_Taxonomy/] comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions. subset: human_subset subset: mouse_subset synonym: "OB FRMD7 GABA" EXACT [] is_a: CL:0000000 ! cell property_value: CLM:0010001 DHBA:10333 {CLM:0010002="0.6", OBI:0000070="EFO:0008992", comment="Location assignment based on CCF broad region."} property_value: IAO:0000028 "OB FRMD7 GABA (Primate)" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#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%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%3D%3D" xsd:string {name="Reference data on Allen Brain Cell Atlas"} property_value: seeAlso "https://purl.brain-bican.org/taxonomy/CCN20230722/CS20250428_NEIGH_0002.h5ad" xsd:string {comment="Warning large data file!", name="h5ad data file for CS20250428_NEIGH_0002"} [Term] id: CL:7770002 name: juxtacanalicular tissue cell def: "A trabecular meshwork cell of the juxtacanalicular tissue (JCT), characterized by a spindle-shaped, fibroblast-like morphology within a loose extracellular matrix immediately adjacent to Schlemm's canal. It expresses CHI3L1 (human and mouse) and ANGPTL7 (human), as well as smooth muscle actin for contractility. Unlike other trabecular meshwork cells, it does not form monolayers but exists in a loose network, regulating aqueous humor outflow resistance through continuous ECM remodelling, mechanotransduction, and formation of intracellular pores historically called giant vacuoles." [PMID:25356439, PMID:32341164, PMID:39829808] subset: human_subset subset: mouse_subset synonym: "JCT cell" RELATED OMO:0003000 [PMID:32341164] is_a: CL:0000151 ! secretory cell is_a: CL:0000327 ! extracellular matrix secreting cell is_a: CL:0002367 ! trabecular meshwork cell relationship: RO:0002215 GO:0070278 ! capable of extracellular matrix constituent secretion property_value: IAO:0000233 "https://github.com/obophenotype/cell-ontology/issues/3275" xsd:string property_value: terms:contributor https://orcid.org/0009-0000-8480-9277 creation_date: 2025-01-29T08:52:00Z [Term] id: CL:7770003 name: beam A cell def: "A beam cell within the eye's trabecular meshwork, molecularly distinguished by FABP4 expression in humans and spatially intermingled with Beam B cells throughout the uveal and corneoscleral meshwork regions. In mice, a transcriptionally analogous Beam A–like cluster (mC14) exists, sharing core TM markers (Myoc, Mgp, Pdpn, Chil1) and functional attributes." [PMID:27443500, PMID:32341164, PMID:39829808] subset: human_subset subset: mouse_subset is_a: CL:7770005 ! beam cell property_value: foaf:depiction "http://purl.obolibrary.org/obo/cl/images/Trabecular_meshowk_cells_PMID35836364.jpg" xsd:string {dc:license="http://creativecommons.org/licenses/by/4.0/", xref="PMID:35836364", comment="Trabecular meshwork (TM) structure. The TM consists of uveal (blue), corneoscleral (red), and juxtacanalicular (green) regions. TM beam cells (blue/red) line the uveal and corneoscleral regions, while JCT cells (green) occupy the juxtacanalicular region."} property_value: terms:contributor https://orcid.org/0009-0000-8480-9277 creation_date: 2025-08-29T08:53:47Z [Term] id: CL:7770004 name: suprabasal cell def: "An epithelial cell that resides in the layer(s) immediately above the basal layer in stratified or pseudostratified epithelia. This cell mainly originates from basal cells and is found across various tissues, including skin, esophagus, oral mucosa, airway, and cornea." [PMID:17020902, PMID:30837987, PMID:32187560, PMID:32726565, PMID:37672481] subset: human_subset subset: mouse_subset is_a: CL:0000066 ! epithelial cell property_value: terms:contributor https://orcid.org/0009-0000-8480-9277 property_value: terms:date "2025-09-05T07:59:28Z" xsd:dateTime [Term] id: CL:7770005 name: beam cell def: "A trabecular meshwork cell that is part of the eye's trabecular meshwork, residing in the uveal and corneoscleral meshwork regions and serving as the primary biological filter in the aqueous humor drainage cascade. This cell exhibits endothelial-like properties, including production of antithrombogenic substances such as tissue plasminogen activator, while also demonstrating phagocytic activity to remove cellular debris from aqueous humour before the fluid moves deeper into the less porous juxtacanalicular tissue." [PMID:25356439, PMID:27443500] subset: human_subset subset: mouse_subset is_a: CL:0000234 ! phagocyte is_a: CL:0002367 {is_inferred="true"} ! trabecular meshwork cell property_value: foaf:depiction "http://purl.obolibrary.org/obo/cl/images/Trabecular_meshowk_cells_PMID35836364.jpg" xsd:string {dc:license="http://creativecommons.org/licenses/by/4.0/", xref="PMID:35836364", comment="Trabecular meshwork (TM) structure. The TM consists of uveal (blue), corneoscleral (red), and juxtacanalicular (green) regions. TM beam cells (blue/red) line the uveal and corneoscleral regions, while JCT cells (green) occupy the juxtacanalicular region."} property_value: terms:contributor https://orcid.org/0009-0000-8480-9277 creation_date: 2025-09-12T11:19:45Z [Term] id: CL:7770006 name: beam B cell, human def: "A trabecular meshwork cell within the eye's trabecular meshwork. This cell is molecularly distinguished by TMEFF2 expression in humans. A beam B cell is spatially intermingled with beam A cells throughout the uveal and corneoscleral meshwork regions, but demonstrates a tendency to localise closer to the juxtacanalicular tissue." [PMID:25356439, PMID:32341164, PMID:39829808] subset: human_subset is_a: BFO:0000002 is_a: CL:0002367 ! trabecular meshwork cell relationship: RO:0002162 NCBITaxon:9606 ! in taxon Homo sapiens relationship: RO:0002292 PR:Q9UIK5 ! expresses tomoregulin-2 (human) property_value: foaf:depiction "http://purl.obolibrary.org/obo/cl/images/Trabecular_meshowk_cells_PMID35836364.jpg" xsd:string {dc:license="http://creativecommons.org/licenses/by/4.0/", xref="PMID:35836364", comment="Trabecular meshwork (TM) structure. The TM consists of uveal (blue), corneoscleral (red), and juxtacanalicular (green) regions. TM beam cells (blue/red) line the uveal and corneoscleral regions, while JCT cells (green) occupy the juxtacanalicular region."} property_value: terms:contributor https://orcid.org/0009-0000-8480-9277 property_value: terms:date "2025-09-15T08:48:01Z" xsd:dateTime [Term] id: CLM:1000001 name: NS forest marker set of alveolar adventitial fibroblast (Human lung). is_a: SO:0001260 ! sequence_collection relationship: BFO:0000051 http://identifiers.org/ensembl/ENSG00000168079 ! has part SCARA5 relationship: BFO:0000051 http://identifiers.org/ensembl/ENSG00000174807 ! has part CD248 property_value: STATO:0000663 "0.85" xsd:string [Term] id: CLM:1000002 name: NS forest marker set of alveolar type 1 fibroblast cell (Human lung). is_a: SO:0001260 ! sequence_collection relationship: BFO:0000051 http://identifiers.org/ensembl/ENSG00000131471 ! has part AOC3 relationship: BFO:0000051 http://identifiers.org/ensembl/ENSG00000139329 ! has part LUM property_value: STATO:0000663 "0.70" xsd:string [Term] id: CLM:1000003 name: NS forest marker set of alveolar macrophage (Human lung). is_a: SO:0001260 ! sequence_collection relationship: BFO:0000051 http://identifiers.org/ensembl/ENSG00000038945 ! has part MSR1 relationship: BFO:0000051 http://identifiers.org/ensembl/ENSG00000170323 ! has part FABP4 property_value: STATO:0000663 "0.80" xsd:string [Term] id: CLM:1000004 name: NS forest marker set of CCL3-positive alveolar macrophage (Human lung). is_a: SO:0001260 ! sequence_collection relationship: BFO:0000051 http://identifiers.org/ensembl/ENSG00000050730 ! has part TNIP3 relationship: BFO:0000051 http://identifiers.org/ensembl/ENSG00000163735 ! has part CXCL5 property_value: STATO:0000663 "0.67" xsd:string [Term] id: CLM:1000005 name: NS forest marker set of metallothionein-positive alveolar macrophage (Human lung). is_a: SO:0001260 ! sequence_collection relationship: BFO:0000051 http://identifiers.org/ensembl/ENSG00000100292 ! has part HMOX1 relationship: BFO:0000051 http://identifiers.org/ensembl/ENSG00000164120 ! has part HPGD property_value: STATO:0000663 "0.41" xsd:string [Term] id: CLM:1000006 name: NS forest marker set of cycling alveolar macrophage (Human lung). is_a: SO:0001260 ! sequence_collection relationship: BFO:0000051 http://identifiers.org/ensembl/ENSG00000137804 ! has part NUSAP1 relationship: BFO:0000051 http://identifiers.org/ensembl/ENSG00000166803 ! has part PCLAF relationship: BFO:0000051 http://identifiers.org/ensembl/ENSG00000171848 ! has part RRM2 relationship: BFO:0000051 http://identifiers.org/ensembl/ENSG00000175063 ! has part UBE2C property_value: STATO:0000663 "0.26" xsd:string [Term] id: CLM:1000008 name: NS forest marker set of pulmonary alveolar type 1 cell (Human lung). is_a: SO:0001260 ! sequence_collection relationship: BFO:0000051 http://identifiers.org/ensembl/ENSG00000204305 ! has part AGER property_value: STATO:0000663 "0.85" xsd:string [Term] id: CLM:1000009 name: NS forest marker set of pulmonary alveolar type 2 cell (Human lung). is_a: SO:0001260 ! sequence_collection relationship: BFO:0000051 http://identifiers.org/ensembl/ENSG00000122852 ! has part SFTPA1 property_value: STATO:0000663 "0.95" xsd:string [Term] id: CLM:1000010 name: NS forest marker set of cycling pulmonary alveolar type 2 cell (Human lung). is_a: SO:0001260 ! sequence_collection relationship: BFO:0000051 http://identifiers.org/ensembl/ENSG00000131747 ! has part TOP2A relationship: BFO:0000051 http://identifiers.org/ensembl/ENSG00000198901 ! has part PRC1 relationship: BFO:0000051 http://identifiers.org/ensembl/ENSG00000242265 ! has part PEG10 property_value: STATO:0000663 "0.61" xsd:string [Term] id: CLM:1000026 name: NS forest marker set of bronchial goblet cell (Human lung). is_a: SO:0001260 ! sequence_collection relationship: BFO:0000051 http://identifiers.org/ensembl/ENSG00000174501 ! has part ANKRD36C relationship: BFO:0000051 http://identifiers.org/ensembl/ENSG00000197943 ! has part PLCG2 property_value: STATO:0000663 "0.55" xsd:string [Term] id: CLM:1000027 name: NS forest marker set of nasal mucosa goblet cell (Human lung). is_a: SO:0001260 ! sequence_collection relationship: BFO:0000051 http://identifiers.org/ensembl/ENSG00000197353 ! has part LYPD2 relationship: BFO:0000051 http://identifiers.org/ensembl/ENSG00000215182 ! has part MUC5AC property_value: STATO:0000663 "0.81" xsd:string [Term] id: CLM:1000031 name: NS forest marker set of lung interstitial macrophage (Human lung). is_a: SO:0001260 ! sequence_collection relationship: BFO:0000051 http://identifiers.org/ensembl/ENSG00000010327 ! has part STAB1 relationship: BFO:0000051 http://identifiers.org/ensembl/ENSG00000072694 ! has part FCGR2B relationship: BFO:0000051 http://identifiers.org/ensembl/ENSG00000124491 ! has part F13A1 property_value: STATO:0000663 "0.46" xsd:string [Term] id: CLM:1000032 name: NS forest marker set of pulmonary ionocyte (Human lung). is_a: SO:0001260 ! sequence_collection relationship: BFO:0000051 http://identifiers.org/ensembl/ENSG00000162399 ! has part BSND relationship: BFO:0000051 http://identifiers.org/ensembl/ENSG00000176009 ! has part ASCL3 property_value: STATO:0000663 "0.82" xsd:string [Term] id: CLM:1000041 name: NS forest marker set of multiciliated columnar cell of tracheobronchial tree (Human lung). is_a: SO:0001260 ! sequence_collection relationship: BFO:0000051 http://identifiers.org/ensembl/ENSG00000166959 ! has part MS4A8 relationship: BFO:0000051 http://identifiers.org/ensembl/ENSG00000179902 ! has part C1orf194 property_value: STATO:0000663 "0.86" xsd:string [Term] id: CLM:1000043 name: NS forest marker set of pulmonary neuroendocrine cell (Human lung). is_a: SO:0001260 ! sequence_collection relationship: BFO:0000051 http://identifiers.org/ensembl/ENSG00000100604 ! has part CHGA relationship: BFO:0000051 http://identifiers.org/ensembl/ENSG00000134443 ! has part GRP property_value: STATO:0000663 "0.94" xsd:string [Term] id: CLM:1000046 name: NS forest marker set of pulmonary interstitial fibroblast (Human lung). is_a: SO:0001260 ! sequence_collection relationship: BFO:0000051 http://identifiers.org/ensembl/ENSG00000143196 ! has part DPT relationship: BFO:0000051 http://identifiers.org/ensembl/ENSG00000189058 ! has part APOD property_value: STATO:0000663 "0.58" xsd:string [Term] id: CLM:1000047 name: NS forest marker set of lung pericyte (Human lung). is_a: SO:0001260 ! sequence_collection relationship: BFO:0000051 http://identifiers.org/ensembl/ENSG00000131097 ! has part HIGD1B relationship: BFO:0000051 http://identifiers.org/ensembl/ENSG00000171303 ! has part KCNK3 property_value: STATO:0000663 "0.84" xsd:string [Term] id: CLM:1000052 name: NS forest marker set of airway submucosal gland collecting duct epithelial cell (Human lung). is_a: SO:0001260 ! sequence_collection relationship: BFO:0000051 http://identifiers.org/ensembl/ENSG00000156689 ! has part GLYATL2 relationship: BFO:0000051 http://identifiers.org/ensembl/ENSG00000187908 ! has part DMBT1 property_value: STATO:0000663 "0.46" xsd:string [Term] id: CLM:1000053 name: NS forest marker set of mucus secreting cell of bronchus submucosal gland (Human lung). is_a: SO:0001260 ! sequence_collection relationship: BFO:0000051 http://identifiers.org/ensembl/ENSG00000078898 ! has part BPIFB2 property_value: STATO:0000663 "0.93" xsd:string [Term] id: CLM:1000054 name: NS forest marker set of serous secreting cell of bronchus submucosal gland (Human lung). is_a: SO:0001260 ! sequence_collection relationship: BFO:0000051 http://identifiers.org/ensembl/ENSG00000111215 ! has part PRR4 relationship: BFO:0000051 http://identifiers.org/ensembl/ENSG00000184530 ! has part C6orf58 property_value: STATO:0000663 "0.75" xsd:string [Term] id: CLM:1000056 name: NS forest marker set of tracheobronchial smooth muscle cell (Human lung). is_a: SO:0001260 ! sequence_collection relationship: BFO:0000051 http://identifiers.org/ensembl/ENSG00000107796 ! has part ACTA2 relationship: BFO:0000051 http://identifiers.org/ensembl/ENSG00000149591 ! has part TAGLN property_value: STATO:0000663 "0.69" xsd:string [Term] id: CLM:1000059 name: NS forest marker set of respiratory tract suprabasal cell (Human lung). is_a: SO:0001260 ! sequence_collection relationship: BFO:0000051 http://identifiers.org/ensembl/ENSG00000041982 ! has part TNC relationship: BFO:0000051 http://identifiers.org/ensembl/ENSG00000171346 ! has part KRT15 relationship: BFO:0000051 http://identifiers.org/ensembl/ENSG00000206073 ! has part SERPINB4 property_value: STATO:0000663 "0.62" xsd:string [Term] id: CLM:1000061 name: NS forest marker set of brush cell of tracheobronchial tree (Human lung). is_a: SO:0001260 ! sequence_collection relationship: BFO:0000051 http://identifiers.org/ensembl/ENSG00000051128 ! has part HOMER3 relationship: BFO:0000051 http://identifiers.org/ensembl/ENSG00000118513 ! has part MYB relationship: BFO:0000051 http://identifiers.org/ensembl/ENSG00000137709 ! has part POU2F3 property_value: STATO:0000663 "0.56" xsd:string [Term] id: CLM:1000063 name: NS forest marker set of pvalb chandelier GABAergic interneuron (Human neocortex). is_a: SO:0001260 ! sequence_collection relationship: BFO:0000051 http://identifiers.org/ensembl/ENSG00000174948 ! has part GPR149 relationship: BFO:0000051 http://identifiers.org/ensembl/ENSG00000178538 ! has part CA8 property_value: STATO:0000663 "0.799748111" xsd:string [Term] id: CLM:1000065 name: NS forest marker set of L2/3 intratelencephalic projecting glutamatergic neuron (Human neocortex). is_a: SO:0001260 ! sequence_collection relationship: BFO:0000051 http://identifiers.org/ensembl/ENSG00000119547 ! has part ONECUT2 relationship: BFO:0000051 http://identifiers.org/ensembl/ENSG00000204262 ! has part COL5A2 property_value: STATO:0000663 "0.670149932" xsd:string [Term] id: CLM:1000066 name: NS forest marker set of L4 intratelencephalic projecting glutamatergic neuron (Human neocortex). is_a: SO:0001260 ! sequence_collection relationship: BFO:0000051 http://identifiers.org/ensembl/ENSG00000113532 ! has part ST8SIA4 relationship: BFO:0000051 http://identifiers.org/ensembl/ENSG00000198963 ! has part RORB property_value: STATO:0000663 "0.720108696" xsd:string [Term] id: CLM:1000067 name: NS forest marker set of L5 extratelencephalic projecting glutamatergic cortical neuron (Human neocortex). is_a: SO:0001260 ! sequence_collection relationship: BFO:0000051 http://identifiers.org/ensembl/ENSG00000124302 ! has part CHST8 relationship: BFO:0000051 http://identifiers.org/ensembl/ENSG00000185668 ! has part POU3F1 property_value: STATO:0000663 "0.815891473" xsd:string [Term] id: CLM:1000068 name: NS forest marker set of L5 intratelencephalic projecting glutamatergic neuron (Human neocortex). is_a: SO:0001260 ! sequence_collection relationship: BFO:0000051 http://identifiers.org/ensembl/ENSG00000082482 ! has part KCNK2 relationship: BFO:0000051 http://identifiers.org/ensembl/ENSG00000180801 ! has part ARSJ relationship: BFO:0000051 http://identifiers.org/ensembl/ENSG00000198963 ! has part RORB property_value: STATO:0000663 "0.764261336" xsd:string [Term] id: CLM:1000069 name: NS forest marker set of L5/6 near-projecting glutamatergic neuron (Human neocortex). is_a: SO:0001260 ! sequence_collection relationship: BFO:0000051 http://identifiers.org/ensembl/ENSG00000038295 ! has part TLL1 relationship: BFO:0000051 http://identifiers.org/ensembl/ENSG00000197085 ! has part NPSR1-AS1 property_value: STATO:0000663 "0.899288218" xsd:string [Term] id: CLM:1000070 name: NS forest marker set of L6 corticothalamic-projecting glutamatergic cortical neuron (Human neocortex). is_a: SO:0001260 ! sequence_collection relationship: BFO:0000051 http://identifiers.org/ensembl/ENSG00000082684 ! has part SEMA5B relationship: BFO:0000051 http://identifiers.org/ensembl/ENSG00000137573 ! has part SULF1 relationship: BFO:0000051 http://identifiers.org/ensembl/ENSG00000178031 ! has part ADAMTSL1 property_value: STATO:0000663 "0.631898455" xsd:string [Term] id: CLM:1000071 name: NS forest marker set of L6 intratelencephalic projecting glutamatergic neuron (Human neocortex). is_a: SO:0001260 ! sequence_collection relationship: BFO:0000051 http://identifiers.org/ensembl/ENSG00000172673 ! has part THEMIS relationship: BFO:0000051 http://identifiers.org/ensembl/ENSG00000256193 ! has part LINC00507 property_value: STATO:0000663 "0.641695703" xsd:string [Term] id: CLM:1000072 name: NS forest marker set of L6 intratelencephalic projecting Car3 glutamatergic neuron (Human neocortex). is_a: SO:0001260 ! sequence_collection relationship: BFO:0000051 http://identifiers.org/ensembl/ENSG00000115593 ! has part SMYD1 relationship: BFO:0000051 http://identifiers.org/ensembl/ENSG00000172673 ! has part THEMIS property_value: STATO:0000663 "0.877752028" xsd:string [Term] id: CLM:1000073 name: NS forest marker set of L6b glutamatergic neuron of the primary motor cortex (Human neocortex). is_a: SO:0001260 ! sequence_collection relationship: BFO:0000051 http://identifiers.org/ensembl/ENSG00000047936 ! has part ROS1 relationship: BFO:0000051 http://identifiers.org/ensembl/ENSG00000118523 ! has part CCN2 property_value: STATO:0000663 "0.819940964" xsd:string [Term] id: CLM:1000074 name: NS forest marker set of lamp5 GABAergic interneuron (Human neocortex). is_a: SO:0001260 ! sequence_collection relationship: BFO:0000051 http://identifiers.org/ensembl/ENSG00000157404 ! has part KIT relationship: BFO:0000051 http://identifiers.org/ensembl/ENSG00000235665 ! has part LINC00298 property_value: STATO:0000663 "0.814687838" xsd:string [Term] id: CLM:1000075 name: NS forest marker set of Lamp5 Lhx6 neuron (Human neocortex). is_a: SO:0001260 ! sequence_collection relationship: BFO:0000051 http://identifiers.org/ensembl/ENSG00000125869 ! has part LAMP5 relationship: BFO:0000051 http://identifiers.org/ensembl/ENSG00000154080 ! has part CHST9 property_value: STATO:0000663 "0.821678322" xsd:string [Term] id: CLM:1000079 name: NS forest marker set of PAX6 GABAergic interneuron (Human neocortex). is_a: SO:0001260 ! sequence_collection relationship: BFO:0000051 http://identifiers.org/ensembl/ENSG00000137252 ! has part HCRTR2 relationship: BFO:0000051 http://identifiers.org/ensembl/ENSG00000189056 ! has part RELN property_value: STATO:0000663 "0.724125093" xsd:string [Term] id: CLM:1000080 name: NS forest marker set of pvalb GABAergic interneuron (Human neocortex). is_a: SO:0001260 ! sequence_collection relationship: BFO:0000051 http://identifiers.org/ensembl/ENSG00000006128 ! has part TAC1 relationship: BFO:0000051 http://identifiers.org/ensembl/ENSG00000100362 ! has part PVALB relationship: BFO:0000051 http://identifiers.org/ensembl/ENSG00000167306 ! has part MYO5B property_value: STATO:0000663 "0.691998764" xsd:string [Term] id: CLM:1000081 name: NS forest marker set of sncg GABAergic interneuron (Human neocortex). is_a: SO:0001260 ! sequence_collection relationship: BFO:0000051 http://identifiers.org/ensembl/ENSG00000143171 ! has part RXRG relationship: BFO:0000051 http://identifiers.org/ensembl/ENSG00000144229 ! has part THSD7B property_value: STATO:0000663 "0.628943702" xsd:string [Term] id: CLM:1000082 name: NS forest marker set of sst GABAergic interneuron (Human neocortex). is_a: SO:0001260 ! sequence_collection relationship: BFO:0000051 http://identifiers.org/ensembl/ENSG00000114805 ! has part PLCH1 relationship: BFO:0000051 http://identifiers.org/ensembl/ENSG00000157005 ! has part SST property_value: STATO:0000663 "0.842367005" xsd:string [Term] id: CLM:1000083 name: NS forest marker set of sst chodl GABAergic interneuron (Human neocortex). is_a: SO:0001260 ! sequence_collection relationship: BFO:0000051 http://identifiers.org/ensembl/ENSG00000122585 ! has part NPY property_value: STATO:0000663 "0.894026187" xsd:string [Term] id: CLM:1000085 name: NS forest marker set of VIP GABAergic interneuron (Human neocortex). is_a: SO:0001260 ! sequence_collection relationship: BFO:0000051 http://identifiers.org/ensembl/ENSG00000146469 ! has part VIP property_value: STATO:0000663 "0.855531344" xsd:string [Term] id: CLM:1001239 name: NS forest marker set of diffuse bipolar 4a cell (Human retina). is_a: SO:0001260 ! sequence_collection relationship: BFO:0000051 http://identifiers.org/ensembl/ENSG00000145730 ! has part PAM relationship: BFO:0000051 http://identifiers.org/ensembl/ENSG00000196569 ! has part LAMA2 property_value: STATO:0000663 "0.608139214" xsd:string [Term] id: CLM:1001240 name: NS forest marker set of OFFx cell (Human retina). is_a: SO:0001260 ! sequence_collection relationship: BFO:0000051 http://identifiers.org/ensembl/ENSG00000047648 ! has part ARHGAP6 relationship: BFO:0000051 http://identifiers.org/ensembl/ENSG00000278254 ! has part AC004852.2 property_value: STATO:0000663 "0.785018957" xsd:string [Term] id: CLM:1001241 name: NS forest marker set of cone retinal bipolar cell (Human retina). is_a: SO:0001260 ! sequence_collection relationship: BFO:0000051 http://identifiers.org/ensembl/ENSG00000082293 ! has part COL19A1 relationship: BFO:0000051 http://identifiers.org/ensembl/ENSG00000101134 ! has part DOK5 property_value: STATO:0000663 "0.843060252" xsd:string [Term] id: CLM:1001242 name: NS forest marker set of diffuse bipolar 3b cell (Human retina). is_a: SO:0001260 ! sequence_collection relationship: BFO:0000051 http://identifiers.org/ensembl/ENSG00000134138 ! has part MEIS2 relationship: BFO:0000051 http://identifiers.org/ensembl/ENSG00000242021 ! has part AC112493.1 property_value: STATO:0000663 "0.821782012" xsd:string [Term] id: CLM:1001243 name: NS forest marker set of diffuse bipolar 1 cell (Human retina). is_a: SO:0001260 ! sequence_collection relationship: BFO:0000051 http://identifiers.org/ensembl/ENSG00000053747 ! has part LAMA3 relationship: BFO:0000051 http://identifiers.org/ensembl/ENSG00000164330 ! has part EBF1 property_value: STATO:0000663 "0.917474411" xsd:string [Term] id: CLM:1001244 name: NS forest marker set of diffuse bipolar 6 cell (Human retina). is_a: SO:0001260 ! sequence_collection relationship: BFO:0000051 http://identifiers.org/ensembl/ENSG00000275443 ! has part AC012409.2 property_value: STATO:0000663 "0.877512571" xsd:string [Term] id: CLM:1001245 name: NS forest marker set of diffuse bipolar 2 cell (Human retina). is_a: SO:0001260 ! sequence_collection relationship: BFO:0000051 http://identifiers.org/ensembl/ENSG00000243004 ! has part ENSG00000243004;AC005062.2;AC005062.1 relationship: BFO:0000051 http://identifiers.org/ensembl/ENSG00000249803 ! has part AC112178.1 property_value: STATO:0000663 "0.770513807" xsd:string [Term] id: CLM:1001246 name: NS forest marker set of diffuse bipolar 4a cell (Human retina). is_a: SO:0001260 ! sequence_collection relationship: BFO:0000051 http://identifiers.org/ensembl/ENSG00000265485 ! has part LINC01915 property_value: STATO:0000663 "0.871187664" xsd:string [Term] id: CLM:1001247 name: NS forest marker set of flat midget bipolar cell (Human retina). is_a: SO:0001260 ! sequence_collection relationship: BFO:0000051 http://identifiers.org/ensembl/ENSG00000163377 ! has part TAFA4 relationship: BFO:0000051 http://identifiers.org/ensembl/ENSG00000185942 ! has part NKAIN3 property_value: STATO:0000663 "0.915774104" xsd:string [Term] id: CLM:1001248 name: NS forest marker set of giant bipolar cell (Human retina). is_a: SO:0001260 ! sequence_collection relationship: BFO:0000051 http://identifiers.org/ensembl/ENSG00000152818 ! has part UTRN property_value: STATO:0000663 "0.808459341" xsd:string [Term] id: CLM:1001249 name: NS forest marker set of diffuse bipolar 3a cell (Human retina). is_a: SO:0001260 ! sequence_collection relationship: BFO:0000051 http://identifiers.org/ensembl/ENSG00000178568 ! has part ERBB4 property_value: STATO:0000663 "0.949243066" xsd:string [Term] id: CLM:1001250 name: NS forest marker set of ON-blue cone bipolar cell (Human retina). is_a: SO:0001260 ! sequence_collection relationship: BFO:0000051 http://identifiers.org/ensembl/ENSG00000183662 ! has part TAFA1 relationship: BFO:0000051 http://identifiers.org/ensembl/ENSG00000250971 ! has part AC110772.2 property_value: STATO:0000663 "0.797269292" xsd:string [Term] id: CLM:1001251 name: NS forest marker set of rod bipolar cell (Human retina). is_a: SO:0001260 ! sequence_collection relationship: BFO:0000051 http://identifiers.org/ensembl/ENSG00000128536 ! has part CDHR3 relationship: BFO:0000051 http://identifiers.org/ensembl/ENSG00000264630 ! has part PRKCA-AS1 property_value: STATO:0000663 "0.929575519" xsd:string [Term] id: CLM:1001252 name: NS forest marker set of invaginating midget bipolar cell (Human retina). is_a: SO:0001260 ! sequence_collection relationship: BFO:0000051 http://identifiers.org/ensembl/ENSG00000189056 ! has part RELN relationship: BFO:0000051 http://identifiers.org/ensembl/ENSG00000271860 ! has part AL589740.1 property_value: STATO:0000663 "0.884807812" xsd:string [Term] id: CLM:1001253 name: NS forest marker set of diffuse bipolar 3b cell (Human retina). is_a: SO:0001260 ! sequence_collection relationship: BFO:0000051 http://identifiers.org/ensembl/ENSG00000175497 ! has part DPP10 relationship: BFO:0000051 http://identifiers.org/ensembl/ENSG00000198691 ! has part ABCA4 property_value: STATO:0000663 "0.765019652" xsd:string [Term] id: CLM:1001254 name: NS forest marker set of diffuse bipolar 1 cell (Human retina). is_a: SO:0001260 ! sequence_collection relationship: BFO:0000051 http://identifiers.org/ensembl/ENSG00000144227 ! has part NXPH2 relationship: BFO:0000051 http://identifiers.org/ensembl/ENSG00000164330 ! has part EBF1 property_value: STATO:0000663 "0.752547687" xsd:string [Term] id: CLM:1001255 name: NS forest marker set of OFFx cell (Human retina). is_a: SO:0001260 ! sequence_collection relationship: BFO:0000051 http://identifiers.org/ensembl/ENSG00000178568 ! has part ERBB4 relationship: BFO:0000051 http://identifiers.org/ensembl/ENSG00000278254 ! has part AC004852.2 property_value: STATO:0000663 "0.722779636" xsd:string [Term] id: CLM:1001256 name: NS forest marker set of diffuse bipolar 4b cell (Human retina). is_a: SO:0001260 ! sequence_collection relationship: BFO:0000051 http://identifiers.org/ensembl/ENSG00000145730 ! has part PAM relationship: BFO:0000051 http://identifiers.org/ensembl/ENSG00000196569 ! has part LAMA2 property_value: STATO:0000663 "0.489741893" xsd:string [Term] id: CLM:1001257 name: NS forest marker set of diffuse bipolar 6 cell (Human retina). is_a: SO:0001260 ! sequence_collection relationship: BFO:0000051 http://identifiers.org/ensembl/ENSG00000275443 ! has part AC012409.2 property_value: STATO:0000663 "0.817444508" xsd:string [Term] id: CLM:1001258 name: NS forest marker set of diffuse bipolar 2 cell (Human retina). is_a: SO:0001260 ! sequence_collection relationship: BFO:0000051 http://identifiers.org/ensembl/ENSG00000163377 ! has part TAFA4 relationship: BFO:0000051 http://identifiers.org/ensembl/ENSG00000171587 ! has part DSCAM property_value: STATO:0000663 "0.886091243" xsd:string [Term] id: CLM:1001259 name: NS forest marker set of ON-blue cone bipolar cell (Human retina). is_a: SO:0001260 ! sequence_collection relationship: BFO:0000051 http://identifiers.org/ensembl/ENSG00000156395 ! has part SORCS3 relationship: BFO:0000051 http://identifiers.org/ensembl/ENSG00000183662 ! has part TAFA1 property_value: STATO:0000663 "0.709302326" xsd:string [Term] id: CLM:1001260 name: NS forest marker set of diffuse bipolar 3a cell (Human retina). is_a: SO:0001260 ! sequence_collection relationship: BFO:0000051 http://identifiers.org/ensembl/ENSG00000267109 ! has part AC011990.1 property_value: STATO:0000663 "0.848827502" xsd:string [Term] id: CLM:1001261 name: NS forest marker set of cone retinal bipolar cell (Human retina). is_a: SO:0001260 ! sequence_collection relationship: BFO:0000051 http://identifiers.org/ensembl/ENSG00000101134 ! has part DOK5 relationship: BFO:0000051 http://identifiers.org/ensembl/ENSG00000184005 ! has part ST6GALNAC3 property_value: STATO:0000663 "0.782434709" xsd:string [Term] id: CLM:1001262 name: NS forest marker set of flat midget bipolar cell (Human retina). is_a: SO:0001260 ! sequence_collection relationship: BFO:0000051 http://identifiers.org/ensembl/ENSG00000163377 ! has part TAFA4 relationship: BFO:0000051 http://identifiers.org/ensembl/ENSG00000171951 ! has part SCG2 property_value: STATO:0000663 "0.891115106" xsd:string [Term] id: CLM:1001263 name: NS forest marker set of diffuse bipolar 4a cell (Human retina). is_a: SO:0001260 ! sequence_collection relationship: BFO:0000051 http://identifiers.org/ensembl/ENSG00000265485 ! has part LINC01915 property_value: STATO:0000663 "0.814956496" xsd:string [Term] id: CLM:1001264 name: NS forest marker set of invaginating midget bipolar cell (Human retina). is_a: SO:0001260 ! sequence_collection relationship: BFO:0000051 http://identifiers.org/ensembl/ENSG00000079691 ! has part CARMIL1 relationship: BFO:0000051 http://identifiers.org/ensembl/ENSG00000196090 ! has part PTPRT property_value: STATO:0000663 "0.80078521" xsd:string [Term] id: CLM:1001265 name: NS forest marker set of giant bipolar cell (Human retina). is_a: SO:0001260 ! sequence_collection relationship: BFO:0000051 http://identifiers.org/ensembl/ENSG00000140538 ! has part NTRK3 relationship: BFO:0000051 http://identifiers.org/ensembl/ENSG00000152818 ! has part UTRN property_value: STATO:0000663 "0.725035162" xsd:string [Term] id: CLM:1001266 name: NS forest marker set of rod bipolar cell (Human retina). is_a: SO:0001260 ! sequence_collection relationship: BFO:0000051 http://identifiers.org/ensembl/ENSG00000154102 ! has part C16orf74 relationship: BFO:0000051 http://identifiers.org/ensembl/ENSG00000227681 ! has part AL033504.1 property_value: STATO:0000663 "0.907779697" xsd:string [Term] id: CLM:5000101 name: Prkch,Slc32a1,Drd1 (Yao). xref: https://doi.org/10.1038/s41586-023-06812-z is_a: SO:0001260 ! sequence_collection relationship: BFO:0000051 http://identifiers.org/ncbigene/13488 ! has part Drd1 (Mmus) relationship: BFO:0000051 http://identifiers.org/ncbigene/18755 ! has part Prkch (Mmus) relationship: BFO:0000051 http://identifiers.org/ncbigene/22348 ! has part Slc32a1 (Mmus) property_value: CLM:0010004 "0.36" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIBMDYxIFNUUiBEMSBHYWJhAAABMTVCSzQ3RENJT0YxU0xMVVc5UAACAAABQ0JHQzBVMzBWVjlKUFI2MFRKVQACAAAEAQECgazGjoGWFSADhGpN%2FYRYGE0ABQMBUHJrY2gAAAFTbGMzMmExAAABRHJkMQAABgEBAlFZNVM4S01PNUhMSlVGMFAwMEsAA34AAAAEAAAIRzRJNEdGSlhKQjlBVFozUFRYMQAJTFZEQkpBVzhCSTVZU1MxUVVCRwAKAAsBbm9uZQACbm9uZQADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAABSzlKTjIzUDI0S1FDR0s5VTc1QQACSFNZWlBaVzE2NjlVODIxQldZUAADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIBMDYxIFNUUiBEMSBHYWJhAAABMTVCSzQ3RENJT0YxU0xMVVc5UAACAAABQ0JHQzBVMzBWVjlKUFI2MFRKVQACAAAEAQAChFC%2FH4OCCX8DhKAah4TEPdkEMk5RVElFN1RBTVA4UFFBSE80UAAFga%2BmSoHprA6BoIFHgJLV6AYABwAABQMBUHJrY2gAAAFTbGMzMmExAAABRHJkMQAABgEBAlFZNVM4S01PNUhMSlVGMFAwMEsAA34AAAAEAAAIVkZPRllQRlFHUktVRFFVWjNGRgAJTFZEQkpBVzhCSTVZU1MxUVVCRwAKAAsBVExPS1dDTDk1UlUwM0Q5UEVURwACNzNHVlREWERFR0UyN00yWEpNVAADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAACAwA%3D" xsd:string {name="markers in reference data on Allen Brain Cell Atlas"} property_value: STATO:0000416 "0.92523366" xsd:float property_value: STATO:0000663 "0.70412517" xsd:float [Term] id: CLM:5000102 name: Adora2a,Phactr1,Pcp4l1 (Yao). xref: https://doi.org/10.1038/s41586-023-06812-z is_a: SO:0001260 ! sequence_collection relationship: BFO:0000051 http://identifiers.org/ncbigene/11540 ! has part Adora2a (Mmus) relationship: BFO:0000051 http://identifiers.org/ncbigene/218194 ! has part Phactr1 (Mmus) relationship: BFO:0000051 http://identifiers.org/ncbigene/66425 ! has part Pcp4l1 (Mmus) property_value: CLM:0010004 "0.2830793905372895" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIBMDYyIFNUUiBEMiBHYWJhAAABMTVCSzQ3RENJT0YxU0xMVVc5UAACAAABQ0JHQzBVMzBWVjlKUFI2MFRKVQACAAAEAQECgazGjoGWFSADhGpN%2FYRYGE0ABQMBQWRvcmEyYQAAAVBoYWN0cjEAAAFQY3A0bDEAAAYBAQJRWTVTOEtNTzVITEpVRjBQMDBLAAN%2BAAAABAAACEc0STRHRkpYSkI5QVRaM1BUWDEACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAW5vbmUAAm5vbmUAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAUs5Sk4yM1AyNEtRQ0dLOVU3NUEAAkhTWVpQWlcxNjY5VTgyMUJXWVAAAwQBRlMwMERYVjBUOVIxWDlGSjRRRQACAAABUVk1UzhLTU81SExKVUYwUDAwSwACATA2MiBTVFIgRDIgR2FiYQAAATE1Qks0N0RDSU9GMVNMTFVXOVAAAgAAAUNCR0MwVTMwVlY5SlBSNjBUSlUAAgAABAEAAoRQvx%2BDggl%2FA4SgGoeExD3ZBDJOUVRJRTdUQU1QOFBRQUhPNFAABYGvpkqB6awOgaCBR4CS1egGAAcAAAUDAUFkb3JhMmEAAAFQaGFjdHIxAAABUGNwNGwxAAAGAQECUVk1UzhLTU81SExKVUYwUDAwSwADfgAAAAQAAAhWRk9GWVBGUUdSS1VEUVVaM0ZGAAlMVkRCSkFXOEJJNVlTUzFRVUJHAAoACwFUTE9LV0NMOTVSVTAzRDlQRVRHAAI3M0dWVERYREVHRTI3TTJYSk1UAAMBBAEAAiMwMDAwMDAAA8gBAAUBAQIjMDAwMDAwAAPIAQAAAAIDAA%3D%3D" xsd:string {name="markers in reference data on Allen Brain Cell Atlas"} property_value: STATO:0000416 "0.99436617" xsd:float property_value: STATO:0000663 "0.6617923" xsd:float [Term] id: CLM:5000348 name: Tmem204,Slc6a5 (Yao). xref: https://doi.org/10.1038/s41586-023-06812-z is_a: SO:0001260 ! sequence_collection relationship: BFO:0000051 http://identifiers.org/ncbigene/104245 ! has part Slc6a5 (Mmus) relationship: BFO:0000051 http://identifiers.org/ncbigene/407831 ! has part Tmem204 (Mmus) property_value: CLM:0010004 "0.1645569620253164" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIBMzA4IERDTyBJbDIyIEdseS1HYWJhAAABMTVCSzQ3RENJT0YxU0xMVVc5UAACAAABQ0JHQzBVMzBWVjlKUFI2MFRKVQACAAAEAQECgazGjoGWFSADhGpN%2FYRYGE0ABQIBVG1lbTIwNAAAAVNsYzZhNQAABgEBAlFZNVM4S01PNUhMSlVGMFAwMEsAA34AAAAEAAAIRzRJNEdGSlhKQjlBVFozUFRYMQAJTFZEQkpBVzhCSTVZU1MxUVVCRwAKAAsBbm9uZQACbm9uZQADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAABSzlKTjIzUDI0S1FDR0s5VTc1QQACSFNZWlBaVzE2NjlVODIxQldZUAADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIBMzA4IERDTyBJbDIyIEdseS1HYWJhAAABMTVCSzQ3RENJT0YxU0xMVVc5UAACAAABQ0JHQzBVMzBWVjlKUFI2MFRKVQACAAAEAQAChFC%2FH4OCCX8DhKAah4TEPdkEMk5RVElFN1RBTVA4UFFBSE80UAAFga%2BmSoHprA6BoIFHgJLV6AYABwAABQIBVG1lbTIwNAAAAVNsYzZhNQAABgEBAlFZNVM4S01PNUhMSlVGMFAwMEsAA34AAAAEAAAIVkZPRllQRlFHUktVRFFVWjNGRgAJTFZEQkpBVzhCSTVZU1MxUVVCRwAKAAsBVExPS1dDTDk1UlUwM0Q5UEVURwACNzNHVlREWERFR0UyN00yWEpNVAADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAACAwA%3D" xsd:string {name="markers in reference data on Allen Brain Cell Atlas"} property_value: STATO:0000416 "0.975" xsd:float property_value: STATO:0000663 "0.49118388" xsd:float [Term] id: CLM:5000349 name: Bmp6,Slc6a5,Zic1,Shisa9,Rgs6 (Yao). xref: https://doi.org/10.1038/s41586-023-06812-z is_a: SO:0001260 ! sequence_collection relationship: BFO:0000051 http://identifiers.org/ncbigene/104245 ! has part Slc6a5 (Mmus) relationship: BFO:0000051 http://identifiers.org/ncbigene/12161 ! has part Bmp6 (Mmus) relationship: BFO:0000051 http://identifiers.org/ncbigene/22771 ! has part Zic1 (Mmus) relationship: BFO:0000051 http://identifiers.org/ncbigene/50779 ! has part Rgs6 (Mmus) relationship: BFO:0000051 http://identifiers.org/ncbigene/72555 ! has part Shisa9 (Mmus) property_value: CLM:0010004 "0.0047058823529411" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#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%2BDggl%2FA4SgGoeExD3ZBDJOUVRJRTdUQU1QOFBRQUhPNFAABYGvpkqB6awOgaCBR4CS1egGAAcAAAUFAUJtcDYAAAFTbGM2YTUAAAFaaWMxAAABU2hpc2E5AAABUmdzNgAABgEBAlFZNVM4S01PNUhMSlVGMFAwMEsAA34AAAAEAAAIVkZPRllQRlFHUktVRFFVWjNGRgAJTFZEQkpBVzhCSTVZU1MxUVVCRwAKAAsBVExPS1dDTDk1UlUwM0Q5UEVURwACNzNHVlREWERFR0UyN00yWEpNVAADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAACAwA%3D" xsd:string {name="markers in reference data on Allen Brain Cell Atlas"} property_value: STATO:0000416 "1.0" xsd:float property_value: STATO:0000663 "0.023094688" xsd:float [Term] id: CLM:5000351 name: Homer3,Tfap2b,Sorcs3,Cacna1e (Yao). xref: https://doi.org/10.1038/s41586-023-06812-z is_a: SO:0001260 ! sequence_collection relationship: BFO:0000051 http://identifiers.org/ncbigene/12290 ! has part Cacna1e (Mmus) relationship: BFO:0000051 http://identifiers.org/ncbigene/21419 ! has part Tfap2b (Mmus) relationship: BFO:0000051 http://identifiers.org/ncbigene/26558 ! has part Homer3 (Mmus) relationship: BFO:0000051 http://identifiers.org/ncbigene/66673 ! has part Sorcs3 (Mmus) property_value: CLM:0010004 "0.06" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#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%2BDggl%2FA4SgGoeExD3ZBDJOUVRJRTdUQU1QOFBRQUhPNFAABYGvpkqB6awOgaCBR4CS1egGAAcAAAUEAUhvbWVyMwAAAVRmYXAyYgAAAVNvcmNzMwAAAUNhY25hMWUAAAYBAQJRWTVTOEtNTzVITEpVRjBQMDBLAAN%2BAAAABAAACFZGT0ZZUEZRR1JLVURRVVozRkYACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAVRMT0tXQ0w5NVJVMDNEOVBFVEcAAjczR1ZURFhERUdFMjdNMlhKTVQAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAgMA" xsd:string {name="markers in reference data on Allen Brain Cell Atlas"} property_value: STATO:0000416 "1.0" xsd:float property_value: STATO:0000663 "0.24193548" xsd:float [Term] id: CLM:5000353 name: Pcp2 (Yao). xref: https://doi.org/10.1038/s41586-023-06812-z is_a: SO:0001260 ! sequence_collection relationship: BFO:0000051 http://identifiers.org/ncbigene/18545 ! has part Pcp2 (Mmus) property_value: CLM:0010004 "0.975609756097561" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIBMzEzIENCWCBQdXJraW5qZSBHYWJhAAABMTVCSzQ3RENJT0YxU0xMVVc5UAACAAABQ0JHQzBVMzBWVjlKUFI2MFRKVQACAAAEAQECgazGjoGWFSADhGpN%2FYRYGE0ABQEBUGNwMgAABgEBAlFZNVM4S01PNUhMSlVGMFAwMEsAA34AAAAEAAAIRzRJNEdGSlhKQjlBVFozUFRYMQAJTFZEQkpBVzhCSTVZU1MxUVVCRwAKAAsBbm9uZQACbm9uZQADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAABSzlKTjIzUDI0S1FDR0s5VTc1QQACSFNZWlBaVzE2NjlVODIxQldZUAADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIBMzEzIENCWCBQdXJraW5qZSBHYWJhAAABMTVCSzQ3RENJT0YxU0xMVVc5UAACAAABQ0JHQzBVMzBWVjlKUFI2MFRKVQACAAAEAQAChFC%2FH4OCCX8DhKAah4TEPdkEMk5RVElFN1RBTVA4UFFBSE80UAAFga%2BmSoHprA6BoIFHgJLV6AYABwAABQEBUGNwMgAABgEBAlFZNVM4S01PNUhMSlVGMFAwMEsAA34AAAAEAAAIVkZPRllQRlFHUktVRFFVWjNGRgAJTFZEQkpBVzhCSTVZU1MxUVVCRwAKAAsBVExPS1dDTDk1UlUwM0Q5UEVURwACNzNHVlREWERFR0UyN00yWEpNVAADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAACAwA%3D" xsd:string {name="markers in reference data on Allen Brain Cell Atlas"} property_value: STATO:0000416 "0.95238096" xsd:float property_value: STATO:0000663 "0.9569378" xsd:float [Term] id: CLM:5000354 name: Gabra6,Ror1 (Yao). xref: https://doi.org/10.1038/s41586-023-06812-z is_a: SO:0001260 ! sequence_collection relationship: BFO:0000051 http://identifiers.org/ncbigene/14399 ! has part Gabra6 (Mmus) relationship: BFO:0000051 http://identifiers.org/ncbigene/26563 ! has part Ror1 (Mmus) property_value: CLM:0010004 "0.252" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIBMzE0IENCIEdyYW51bGUgR2x1dAAAATE1Qks0N0RDSU9GMVNMTFVXOVAAAgAAAUNCR0MwVTMwVlY5SlBSNjBUSlUAAgAABAEBAoGsxo6BlhUgA4RqTf2EWBhNAAUCAUdhYnJhNgAAAVJvcjEAAAYBAQJRWTVTOEtNTzVITEpVRjBQMDBLAAN%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%3D%3D" xsd:string {name="markers in reference data on Allen Brain Cell Atlas"} property_value: STATO:0000416 "1.0" xsd:float property_value: STATO:0000663 "0.62749004" xsd:float [Term] id: CLM:5000358 name: Aqp4,Cd38,Agt,Itih3 (Yao). xref: https://doi.org/10.1038/s41586-023-06812-z is_a: SO:0001260 ! sequence_collection relationship: BFO:0000051 http://identifiers.org/ncbigene/11606 ! has part Agt (Mmus) relationship: BFO:0000051 http://identifiers.org/ncbigene/11829 ! has part Aqp4 (Mmus) relationship: BFO:0000051 http://identifiers.org/ncbigene/12494 ! has part Cd38 (Mmus) relationship: BFO:0000051 http://identifiers.org/ncbigene/16426 ! has part Itih3 (Mmus) property_value: CLM:0010004 "0.126068376068376" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIBMzE4IEFzdHJvLU5UIE5OAAABMTVCSzQ3RENJT0YxU0xMVVc5UAACAAABQ0JHQzBVMzBWVjlKUFI2MFRKVQACAAAEAQECgazGjoGWFSADhGpN%2FYRYGE0ABQQBQXFwNAAAAUNkMzgAAAFBZ3QAAAFJdGloMwAABgEBAlFZNVM4S01PNUhMSlVGMFAwMEsAA34AAAAEAAAIRzRJNEdGSlhKQjlBVFozUFRYMQAJTFZEQkpBVzhCSTVZU1MxUVVCRwAKAAsBbm9uZQACbm9uZQADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAABSzlKTjIzUDI0S1FDR0s5VTc1QQACSFNZWlBaVzE2NjlVODIxQldZUAADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIBMzE4IEFzdHJvLU5UIE5OAAABMTVCSzQ3RENJT0YxU0xMVVc5UAACAAABQ0JHQzBVMzBWVjlKUFI2MFRKVQACAAAEAQAChFC%2FH4OCCX8DhKAah4TEPdkEMk5RVElFN1RBTVA4UFFBSE80UAAFga%2BmSoHprA6BoIFHgJLV6AYABwAABQQBQXFwNAAAAUNkMzgAAAFBZ3QAAAFJdGloMwAABgEBAlFZNVM4S01PNUhMSlVGMFAwMEsAA34AAAAEAAAIVkZPRllQRlFHUktVRFFVWjNGRgAJTFZEQkpBVzhCSTVZU1MxUVVCRwAKAAsBVExPS1dDTDk1UlUwM0Q5UEVURwACNzNHVlREWERFR0UyN00yWEpNVAADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAACAwA%3D" xsd:string {name="markers in reference data on Allen Brain Cell Atlas"} property_value: STATO:0000416 "0.9076923" xsd:float property_value: STATO:0000663 "0.4052198" xsd:float [Term] id: CLM:5000359 name: Gja1,Lhx2,Gpc5,Nr2f1 (Yao). xref: https://doi.org/10.1038/s41586-023-06812-z is_a: SO:0001260 ! sequence_collection relationship: BFO:0000051 http://identifiers.org/ncbigene/103978 ! has part Gpc5 (Mmus) relationship: BFO:0000051 http://identifiers.org/ncbigene/13865 ! has part Nr2f1 (Mmus) relationship: BFO:0000051 http://identifiers.org/ncbigene/14609 ! has part Gja1 (Mmus) relationship: BFO:0000051 http://identifiers.org/ncbigene/16870 ! has part Lhx2 (Mmus) property_value: CLM:0010004 "0.0081967213114754" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIBMzE5IEFzdHJvLVRFIE5OAAABMTVCSzQ3RENJT0YxU0xMVVc5UAACAAABQ0JHQzBVMzBWVjlKUFI2MFRKVQACAAAEAQECgazGjoGWFSADhGpN%2FYRYGE0ABQQBR2phMQAAAUxoeDIAAAFHcGM1AAABTnIyZjEAAAYBAQJRWTVTOEtNTzVITEpVRjBQMDBLAAN%2BAAAABAAACEc0STRHRkpYSkI5QVRaM1BUWDEACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAW5vbmUAAm5vbmUAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAUs5Sk4yM1AyNEtRQ0dLOVU3NUEAAkhTWVpQWlcxNjY5VTgyMUJXWVAAAwQBRlMwMERYVjBUOVIxWDlGSjRRRQACAAABUVk1UzhLTU81SExKVUYwUDAwSwACATMxOSBBc3Ryby1URSBOTgAAATE1Qks0N0RDSU9GMVNMTFVXOVAAAgAAAUNCR0MwVTMwVlY5SlBSNjBUSlUAAgAABAEAAoRQvx%2BDggl%2FA4SgGoeExD3ZBDJOUVRJRTdUQU1QOFBRQUhPNFAABYGvpkqB6awOgaCBR4CS1egGAAcAAAUEAUdqYTEAAAFMaHgyAAABR3BjNQAAAU5yMmYxAAAGAQECUVk1UzhLTU81SExKVUYwUDAwSwADfgAAAAQAAAhWRk9GWVBGUUdSS1VEUVVaM0ZGAAlMVkRCSkFXOEJJNVlTUzFRVUJHAAoACwFUTE9LV0NMOTVSVTAzRDlQRVRHAAI3M0dWVERYREVHRTI3TTJYSk1UAAMBBAEAAiMwMDAwMDAAA8gBAAUBAQIjMDAwMDAwAAPIAQAAAAIDAA%3D%3D" xsd:string {name="markers in reference data on Allen Brain Cell Atlas"} property_value: STATO:0000416 "1.0" xsd:float property_value: STATO:0000663 "0.03968254" xsd:float [Term] id: CLM:5000360 name: Gja1,Hs3st3a1 (Yao). xref: https://doi.org/10.1038/s41586-023-06812-z is_a: SO:0001260 ! sequence_collection relationship: BFO:0000051 http://identifiers.org/ncbigene/14609 ! has part Gja1 (Mmus) relationship: BFO:0000051 http://identifiers.org/ncbigene/15478 ! has part Hs3st3a1 (Mmus) property_value: CLM:0010004 "0.4133333333333333" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#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%2BDggl%2FA4SgGoeExD3ZBDJOUVRJRTdUQU1QOFBRQUhPNFAABYGvpkqB6awOgaCBR4CS1egGAAcAAAUCAUdqYTEAAAFIczNzdDNhMQAABgEBAlFZNVM4S01PNUhMSlVGMFAwMEsAA34AAAAEAAAIVkZPRllQRlFHUktVRFFVWjNGRgAJTFZEQkpBVzhCSTVZU1MxUVVCRwAKAAsBVExPS1dDTDk1UlUwM0Q5UEVURwACNzNHVlREWERFR0UyN00yWEpNVAADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAACAwA%3D" xsd:string {name="markers in reference data on Allen Brain Cell Atlas"} property_value: STATO:0000416 "0.7948718" xsd:float property_value: STATO:0000663 "0.67099565" xsd:float [Term] id: CLM:5000362 name: Gpr50,Apoe (Yao). xref: https://doi.org/10.1038/s41586-023-06812-z is_a: SO:0001260 ! sequence_collection relationship: BFO:0000051 http://identifiers.org/ncbigene/11816 ! has part Apoe (Mmus) relationship: BFO:0000051 http://identifiers.org/ncbigene/14765 ! has part Gpr50 (Mmus) property_value: CLM:0010004 "0.6027397260273972" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIBMzIyIFRhbnljeXRlIE5OAAABMTVCSzQ3RENJT0YxU0xMVVc5UAACAAABQ0JHQzBVMzBWVjlKUFI2MFRKVQACAAAEAQECgazGjoGWFSADhGpN%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%2BAAAABAAACFZGT0ZZUEZRR1JLVURRVVozRkYACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAVRMT0tXQ0w5NVJVMDNEOVBFVEcAAjczR1ZURFhERUdFMjdNMlhKTVQAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAgMA" xsd:string {name="markers in reference data on Allen Brain Cell Atlas"} property_value: STATO:0000416 "0.79710144" xsd:float property_value: STATO:0000663 "0.74880874" xsd:float [Term] id: CLM:5000363 name: Tmem212,Rarres2 (Yao). xref: https://doi.org/10.1038/s41586-023-06812-z is_a: SO:0001260 ! sequence_collection relationship: BFO:0000051 http://identifiers.org/ncbigene/208613 ! has part Tmem212 (Mmus) relationship: BFO:0000051 http://identifiers.org/ncbigene/71660 ! has part Rarres2 (Mmus) property_value: CLM:0010004 "0.806049822064057" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#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%2FH4OCCX8DhKAah4TEPdkEMk5RVElFN1RBTVA4UFFBSE80UAAFga%2BmSoHprA6BoIFHgJLV6AYABwAABQIBVG1lbTIxMgAAAVJhcnJlczIAAAYBAQJRWTVTOEtNTzVITEpVRjBQMDBLAAN%2BAAAABAAACFZGT0ZZUEZRR1JLVURRVVozRkYACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAVRMT0tXQ0w5NVJVMDNEOVBFVEcAAjczR1ZURFhERUdFMjdNMlhKTVQAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAgMA" xsd:string {name="markers in reference data on Allen Brain Cell Atlas"} property_value: STATO:0000416 "0.9956044" xsd:float property_value: STATO:0000663 "0.9508816" xsd:float [Term] id: CLM:5000366 name: Pdgfra (Yao). xref: https://doi.org/10.1038/s41586-023-06812-z is_a: SO:0001260 ! sequence_collection relationship: BFO:0000051 http://identifiers.org/ncbigene/18595 ! has part Pdgfra (Mmus) property_value: CLM:0010004 "0.91" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#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%2BDggl%2FA4SgGoeExD3ZBDJOUVRJRTdUQU1QOFBRQUhPNFAABYGvpkqB6awOgaCBR4CS1egGAAcAAAUBAVBkZ2ZyYQAABgEBAlFZNVM4S01PNUhMSlVGMFAwMEsAA34AAAAEAAAIVkZPRllQRlFHUktVRFFVWjNGRgAJTFZEQkpBVzhCSTVZU1MxUVVCRwAKAAsBVExPS1dDTDk1UlUwM0Q5UEVURwACNzNHVlREWERFR0UyN00yWEpNVAADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAACAwA%3D" xsd:string {name="markers in reference data on Allen Brain Cell Atlas"} property_value: STATO:0000416 "0.67574257" xsd:float property_value: STATO:0000663 "0.7124217" xsd:float [Term] id: CLM:5000367 name: Cldn11,Gjc3 (Yao). xref: https://doi.org/10.1038/s41586-023-06812-z is_a: SO:0001260 ! sequence_collection relationship: BFO:0000051 http://identifiers.org/ncbigene/118446 ! has part Gjc3 (Mmus) relationship: BFO:0000051 http://identifiers.org/ncbigene/18417 ! has part Cldn11 (Mmus) property_value: CLM:0010004 "0.7300613496932515" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIBMzI3IE9saWdvIE5OAAABMTVCSzQ3RENJT0YxU0xMVVc5UAACAAABQ0JHQzBVMzBWVjlKUFI2MFRKVQACAAAEAQECgazGjoGWFSADhGpN%2FYRYGE0ABQIBQ2xkbjExAAABR2pjMwAABgEBAlFZNVM4S01PNUhMSlVGMFAwMEsAA34AAAAEAAAIRzRJNEdGSlhKQjlBVFozUFRYMQAJTFZEQkpBVzhCSTVZU1MxUVVCRwAKAAsBbm9uZQACbm9uZQADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAABSzlKTjIzUDI0S1FDR0s5VTc1QQACSFNZWlBaVzE2NjlVODIxQldZUAADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIBMzI3IE9saWdvIE5OAAABMTVCSzQ3RENJT0YxU0xMVVc5UAACAAABQ0JHQzBVMzBWVjlKUFI2MFRKVQACAAAEAQAChFC%2FH4OCCX8DhKAah4TEPdkEMk5RVElFN1RBTVA4UFFBSE80UAAFga%2BmSoHprA6BoIFHgJLV6AYABwAABQIBQ2xkbjExAAABR2pjMwAABgEBAlFZNVM4S01PNUhMSlVGMFAwMEsAA34AAAAEAAAIVkZPRllQRlFHUktVRFFVWjNGRgAJTFZEQkpBVzhCSTVZU1MxUVVCRwAKAAsBVExPS1dDTDk1UlUwM0Q5UEVURwACNzNHVlREWERFR0UyN00yWEpNVAADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAACAwA%3D" xsd:string {name="markers in reference data on Allen Brain Cell Atlas"} property_value: STATO:0000416 "0.9883721" xsd:float property_value: STATO:0000663 "0.9230531" xsd:float [Term] id: CLM:5000370 name: Apod,Slc6a13 (Yao). xref: https://doi.org/10.1038/s41586-023-06812-z is_a: SO:0001260 ! sequence_collection relationship: BFO:0000051 http://identifiers.org/ncbigene/11815 ! has part Apod (Mmus) relationship: BFO:0000051 http://identifiers.org/ncbigene/14412 ! has part Slc6a13 (Mmus) property_value: CLM:0010004 "0.62" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#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%3D" xsd:string {name="markers in reference data on Allen Brain Cell Atlas"} property_value: STATO:0000416 "0.984127" xsd:float property_value: STATO:0000663 "0.8806818" xsd:float [Term] id: CLM:5001561 name: Il22,Rftn1 (Yao). xref: https://doi.org/10.1038/s41586-023-06812-z is_a: SO:0001260 ! sequence_collection relationship: BFO:0000051 http://identifiers.org/ncbigene/50929 ! has part Il22 (Mmus) relationship: BFO:0000051 http://identifiers.org/ncbigene/76438 ! has part Rftn1 (Mmus) property_value: CLM:0010004 "0.1041666666666666" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIBMTE0MSBEQ08gSWwyMiBHbHktR2FiYV8xAAABQ0JHQzBVMzBWVjlKUFI2MFRKVQACAAAEAQECgazGjoGWFSADhGpN%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%2BAAAABAAACFZGT0ZZUEZRR1JLVURRVVozRkYACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAVRMT0tXQ0w5NVJVMDNEOVBFVEcAAjczR1ZURFhERUdFMjdNMlhKTVQAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAgMA" xsd:string {name="markers in reference data on Allen Brain Cell Atlas"} property_value: STATO:0000416 "0.46296296" xsd:float property_value: STATO:0000663 "0.2741228" xsd:float [Term] id: CLM:5001563 name: Fat2,Slc6a5,Cgnl1 (Yao). xref: https://doi.org/10.1038/s41586-023-06812-z is_a: SO:0001260 ! sequence_collection relationship: BFO:0000051 http://identifiers.org/ncbigene/104245 ! has part Slc6a5 (Mmus) relationship: BFO:0000051 http://identifiers.org/ncbigene/245827 ! has part Fat2 (Mmus) relationship: BFO:0000051 http://identifiers.org/ncbigene/68178 ! has part Cgnl1 (Mmus) property_value: CLM:0010004 "0.1467391304347826" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIBMTE0MyBEQ08gSWwyMiBHbHktR2FiYV8zAAABQ0JHQzBVMzBWVjlKUFI2MFRKVQACAAAEAQECgazGjoGWFSADhGpN%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%2BAAAABAAACFZGT0ZZUEZRR1JLVURRVVozRkYACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAVRMT0tXQ0w5NVJVMDNEOVBFVEcAAjczR1ZURFhERUdFMjdNMlhKTVQAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAgMA" xsd:string {name="markers in reference data on Allen Brain Cell Atlas"} property_value: STATO:0000416 "0.96428573" xsd:float property_value: STATO:0000663 "0.4560811" xsd:float [Term] id: CLM:5001564 name: Hmga2,Afap1l2 (Yao). xref: https://doi.org/10.1038/s41586-023-06812-z is_a: SO:0001260 ! sequence_collection relationship: BFO:0000051 http://identifiers.org/ncbigene/15364 ! has part Hmga2 (Mmus) relationship: BFO:0000051 http://identifiers.org/ncbigene/226250 ! has part Afap1l2 (Mmus) property_value: CLM:0010004 "0.1724137931034483" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#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%2BDggl%2FA4SgGoeExD3ZBDJOUVRJRTdUQU1QOFBRQUhPNFAABYGvpkqB6awOgaCBR4CS1egGAAcAAAUCAUhtZ2EyAAABQWZhcDFsMgAABgEBAjE1Qks0N0RDSU9GMVNMTFVXOVAAA34AAAAEAAAIVkZPRllQRlFHUktVRFFVWjNGRgAJTFZEQkpBVzhCSTVZU1MxUVVCRwAKAAsBVExPS1dDTDk1UlUwM0Q5UEVURwACNzNHVlREWERFR0UyN00yWEpNVAADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAACAwA%3D" xsd:string {name="markers in reference data on Allen Brain Cell Atlas"} property_value: STATO:0000416 "0.9259259" xsd:float property_value: STATO:0000663 "0.49407116" xsd:float [Term] id: CLM:5001565 name: Pthlh,Tfap2b,Rspo2 (Yao). xref: https://doi.org/10.1038/s41586-023-06812-z is_a: SO:0001260 ! sequence_collection relationship: BFO:0000051 http://identifiers.org/ncbigene/19227 ! has part Pthlh (Mmus) relationship: BFO:0000051 http://identifiers.org/ncbigene/21419 ! has part Tfap2b (Mmus) relationship: BFO:0000051 http://identifiers.org/ncbigene/239405 ! has part Rspo2 (Mmus) property_value: CLM:0010004 "0.3846153846153846" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIBMTE0NSBDQiBQTEkgR2x5LUdhYmFfMgAAAUNCR0MwVTMwVlY5SlBSNjBUSlUAAgAABAEBAoGsxo6BlhUgA4RqTf2EWBhNAAUDAVB0aGxoAAABVGZhcDJiAAABUnNwbzIAAAYBAQIxNUJLNDdEQ0lPRjFTTExVVzlQAAN%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%3D%3D" xsd:string {name="markers in reference data on Allen Brain Cell Atlas"} property_value: STATO:0000416 "0.98039216" xsd:float property_value: STATO:0000663 "0.74850297" xsd:float [Term] id: CLM:5001566 name: Pax2,C1ql3,Tfap2b,Gabrb1 (Yao). xref: https://doi.org/10.1038/s41586-023-06812-z is_a: SO:0001260 ! sequence_collection relationship: BFO:0000051 http://identifiers.org/ncbigene/14400 ! has part Gabrb1 (Mmus) relationship: BFO:0000051 http://identifiers.org/ncbigene/18504 ! has part Pax2 (Mmus) relationship: BFO:0000051 http://identifiers.org/ncbigene/21419 ! has part Tfap2b (Mmus) relationship: BFO:0000051 http://identifiers.org/ncbigene/227580 ! has part C1ql3 (Mmus) property_value: CLM:0010004 "0.1" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#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%2BDggl%2FA4SgGoeExD3ZBDJOUVRJRTdUQU1QOFBRQUhPNFAABYGvpkqB6awOgaCBR4CS1egGAAcAAAUEAVBheDIAAAFDMXFsMwAAAVRmYXAyYgAAAUdhYnJiMQAABgEBAjE1Qks0N0RDSU9GMVNMTFVXOVAAA34AAAAEAAAIVkZPRllQRlFHUktVRFFVWjNGRgAJTFZEQkpBVzhCSTVZU1MxUVVCRwAKAAsBVExPS1dDTDk1UlUwM0Q5UEVURwACNzNHVlREWERFR0UyN00yWEpNVAADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAACAwA%3D" xsd:string {name="markers in reference data on Allen Brain Cell Atlas"} property_value: STATO:0000416 "0.625" xsd:float property_value: STATO:0000663 "0.30487806" xsd:float [Term] id: CLM:5001568 name: Zfp385c,Tfap2b (Yao). xref: https://doi.org/10.1038/s41586-023-06812-z is_a: SO:0001260 ! sequence_collection relationship: BFO:0000051 http://identifiers.org/ncbigene/21419 ! has part Tfap2b (Mmus) relationship: BFO:0000051 http://identifiers.org/ncbigene/278304 ! has part Zfp385c (Mmus) property_value: CLM:0010004 "0.64" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIBMzEwIENCWCBHb2xnaSBHbHktR2FiYQAAATE1Qks0N0RDSU9GMVNMTFVXOVAAAgAAAUNCR0MwVTMwVlY5SlBSNjBUSlUAAgAABAEBAoGsxo6BlhUgA4RqTf2EWBhNAAUCAVpmcDM4NWMAAAFUZmFwMmIAAAYBAQJRWTVTOEtNTzVITEpVRjBQMDBLAAN%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%3D%3D" xsd:string {name="markers in reference data on Allen Brain Cell Atlas"} property_value: STATO:0000416 "0.6037736" xsd:float property_value: STATO:0000663 "0.610687" xsd:float [Term] id: CLM:5001569 name: Dnah11,Sla,Gldc,Sdk2 (Yao). xref: https://doi.org/10.1038/s41586-023-06812-z is_a: SO:0001260 ! sequence_collection relationship: BFO:0000051 http://identifiers.org/ncbigene/104174 ! has part Gldc (Mmus) relationship: BFO:0000051 http://identifiers.org/ncbigene/13411 ! has part Dnah11 (Mmus) relationship: BFO:0000051 http://identifiers.org/ncbigene/20491 ! has part Sla (Mmus) relationship: BFO:0000051 http://identifiers.org/ncbigene/237979 ! has part Sdk2 (Mmus) property_value: CLM:0010004 "0.08" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIBMTE0OSBDQlggTUxJIE1lZ2YxMSBHYWJhXzEAAAFDQkdDMFUzMFZWOUpQUjYwVEpVAAIAAAQBAQKBrMaOgZYVIAOEak39hFgYTQAFBAFEbmFoMTEAAAFTbGEAAAFHbGRjAAABU2RrMgAABgEBAjE1Qks0N0RDSU9GMVNMTFVXOVAAA34AAAAEAAAIRzRJNEdGSlhKQjlBVFozUFRYMQAJTFZEQkpBVzhCSTVZU1MxUVVCRwAKAAsBbm9uZQACbm9uZQADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAABSzlKTjIzUDI0S1FDR0s5VTc1QQACSFNZWlBaVzE2NjlVODIxQldZUAADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIBMTE0OSBDQlggTUxJIE1lZ2YxMSBHYWJhXzEAAAFDQkdDMFUzMFZWOUpQUjYwVEpVAAIAAAQBAAKEUL8fg4IJfwOEoBqHhMQ92QQyTlFUSUU3VEFNUDhQUUFITzRQAAWBr6ZKgemsDoGggUeAktXoBgAHAAAFBAFEbmFoMTEAAAFTbGEAAAFHbGRjAAABU2RrMgAABgEBAjE1Qks0N0RDSU9GMVNMTFVXOVAAA34AAAAEAAAIVkZPRllQRlFHUktVRFFVWjNGRgAJTFZEQkpBVzhCSTVZU1MxUVVCRwAKAAsBVExPS1dDTDk1UlUwM0Q5UEVURwACNzNHVlREWERFR0UyN00yWEpNVAADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAACAwA%3D" xsd:string {name="markers in reference data on Allen Brain Cell Atlas"} property_value: STATO:0000416 "1.0" xsd:float property_value: STATO:0000663 "0.3030303" xsd:float [Term] id: CLM:5001570 name: Gabra6,Pvalb (Yao). xref: https://doi.org/10.1038/s41586-023-06812-z is_a: SO:0001260 ! sequence_collection relationship: BFO:0000051 http://identifiers.org/ncbigene/14399 ! has part Gabra6 (Mmus) relationship: BFO:0000051 http://identifiers.org/ncbigene/19293 ! has part Pvalb (Mmus) property_value: CLM:0010004 "0.46" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#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%3D" xsd:string {name="markers in reference data on Allen Brain Cell Atlas"} property_value: STATO:0000416 "0.9787234" xsd:float property_value: STATO:0000663 "0.7986111" xsd:float [Term] id: CLM:5001572 name: Pcp2,Stk17b (Yao). xref: https://doi.org/10.1038/s41586-023-06812-z is_a: SO:0001260 ! sequence_collection relationship: BFO:0000051 http://identifiers.org/ncbigene/18545 ! has part Pcp2 (Mmus) relationship: BFO:0000051 http://identifiers.org/ncbigene/98267 ! has part Stk17b (Mmus) property_value: CLM:0010004 "0.8247422680412371" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIBMTE1MiBDQlggUHVya2luamUgR2FiYV8xAAABQ0JHQzBVMzBWVjlKUFI2MFRKVQACAAAEAQECgazGjoGWFSADhGpN%2FYRYGE0ABQIBUGNwMgAAAVN0azE3YgAABgEBAjE1Qks0N0RDSU9GMVNMTFVXOVAAA34AAAAEAAAIRzRJNEdGSlhKQjlBVFozUFRYMQAJTFZEQkpBVzhCSTVZU1MxUVVCRwAKAAsBbm9uZQACbm9uZQADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAABSzlKTjIzUDI0S1FDR0s5VTc1QQACSFNZWlBaVzE2NjlVODIxQldZUAADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIBMTE1MiBDQlggUHVya2luamUgR2FiYV8xAAABQ0JHQzBVMzBWVjlKUFI2MFRKVQACAAAEAQAChFC%2FH4OCCX8DhKAah4TEPdkEMk5RVElFN1RBTVA4UFFBSE80UAAFga%2BmSoHprA6BoIFHgJLV6AYABwAABQIBUGNwMgAAAVN0azE3YgAABgEBAjE1Qks0N0RDSU9GMVNMTFVXOVAAA34AAAAEAAAIVkZPRllQRlFHUktVRFFVWjNGRgAJTFZEQkpBVzhCSTVZU1MxUVVCRwAKAAsBVExPS1dDTDk1UlUwM0Q5UEVURwACNzNHVlREWERFR0UyN00yWEpNVAADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAACAwA%3D" xsd:string {name="markers in reference data on Allen Brain Cell Atlas"} property_value: STATO:0000416 "0.5714286" xsd:float property_value: STATO:0000663 "0.608828" xsd:float [Term] id: CLM:5001574 name: Gabra6,Lmx1a (Yao). xref: https://doi.org/10.1038/s41586-023-06812-z is_a: SO:0001260 ! sequence_collection relationship: BFO:0000051 http://identifiers.org/ncbigene/110648 ! has part Lmx1a (Mmus) relationship: BFO:0000051 http://identifiers.org/ncbigene/14399 ! has part Gabra6 (Mmus) property_value: CLM:0010004 "0.1" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#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%2FH4OCCX8DhKAah4TEPdkEMk5RVElFN1RBTVA4UFFBSE80UAAFga%2BmSoHprA6BoIFHgJLV6AYABwAABQIBR2FicmE2AAABTG14MWEAAAYBAQIxNUJLNDdEQ0lPRjFTTExVVzlQAAN%2BAAAABAAACFZGT0ZZUEZRR1JLVURRVVozRkYACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAVRMT0tXQ0w5NVJVMDNEOVBFVEcAAjczR1ZURFhERUdFMjdNMlhKTVQAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAgMA" xsd:string {name="markers in reference data on Allen Brain Cell Atlas"} property_value: STATO:0000416 "1.0" xsd:float property_value: STATO:0000663 "0.35714287" xsd:float [Term] id: CLM:5001575 name: Gabra6,Gap43,Rab37 (Yao). xref: https://doi.org/10.1038/s41586-023-06812-z is_a: SO:0001260 ! sequence_collection relationship: BFO:0000051 http://identifiers.org/ncbigene/14399 ! has part Gabra6 (Mmus) relationship: BFO:0000051 http://identifiers.org/ncbigene/14432 ! has part Gap43 (Mmus) relationship: BFO:0000051 http://identifiers.org/ncbigene/58222 ! has part Rab37 (Mmus) property_value: CLM:0010004 "0.06" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIBMTE1NSBDQiBHcmFudWxlIEdsdXRfMgAAAUNCR0MwVTMwVlY5SlBSNjBUSlUAAgAABAEBAoGsxo6BlhUgA4RqTf2EWBhNAAUDAUdhYnJhNgAAAUdhcDQzAAABUmFiMzcAAAYBAQIxNUJLNDdEQ0lPRjFTTExVVzlQAAN%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%3D%3D" xsd:string {name="markers in reference data on Allen Brain Cell Atlas"} property_value: STATO:0000416 "1.0" xsd:float property_value: STATO:0000663 "0.24193548" xsd:float [Term] id: CLM:5001576 name: Sln,Lmx1a (Yao). xref: https://doi.org/10.1038/s41586-023-06812-z is_a: SO:0001260 ! sequence_collection relationship: BFO:0000051 http://identifiers.org/ncbigene/110648 ! has part Lmx1a (Mmus) relationship: BFO:0000051 http://identifiers.org/ncbigene/66402 ! has part Sln (Mmus) property_value: CLM:0010004 "0.235" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#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%2FH4OCCX8DhKAah4TEPdkEMk5RVElFN1RBTVA4UFFBSE80UAAFga%2BmSoHprA6BoIFHgJLV6AYABwAABQIBU2xuAAABTG14MWEAAAYBAQJRWTVTOEtNTzVITEpVRjBQMDBLAAN%2BAAAABAAACFZGT0ZZUEZRR1JLVURRVVozRkYACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAVRMT0tXQ0w5NVJVMDNEOVBFVEcAAjczR1ZURFhERUdFMjdNMlhKTVQAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAgMA" xsd:string {name="markers in reference data on Allen Brain Cell Atlas"} property_value: STATO:0000416 "0.94" xsd:float property_value: STATO:0000663 "0.5875" xsd:float [Term] id: CLM:5001579 name: Gfap,Lhfpl3,Gria1,Hopx (Yao). xref: https://doi.org/10.1038/s41586-023-06812-z is_a: SO:0001260 ! sequence_collection relationship: BFO:0000051 http://identifiers.org/ncbigene/14580 ! has part Gfap (Mmus) relationship: BFO:0000051 http://identifiers.org/ncbigene/14799 ! has part Gria1 (Mmus) relationship: BFO:0000051 http://identifiers.org/ncbigene/269629 ! has part Lhfpl3 (Mmus) relationship: BFO:0000051 http://identifiers.org/ncbigene/74318 ! has part Hopx (Mmus) property_value: CLM:0010004 "0.0335820895522388" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIBMTE1OSBBc3Ryby1OVCBOTl8xAAABQ0JHQzBVMzBWVjlKUFI2MFRKVQACAAAEAQECgazGjoGWFSADhGpN%2FYRYGE0ABQQBR2ZhcAAAAUxoZnBsMwAAAUdyaWExAAABSG9weAAABgEBAjE1Qks0N0RDSU9GMVNMTFVXOVAAA34AAAAEAAAIRzRJNEdGSlhKQjlBVFozUFRYMQAJTFZEQkpBVzhCSTVZU1MxUVVCRwAKAAsBbm9uZQACbm9uZQADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAABSzlKTjIzUDI0S1FDR0s5VTc1QQACSFNZWlBaVzE2NjlVODIxQldZUAADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIBMTE1OSBBc3Ryby1OVCBOTl8xAAABQ0JHQzBVMzBWVjlKUFI2MFRKVQACAAAEAQAChFC%2FH4OCCX8DhKAah4TEPdkEMk5RVElFN1RBTVA4UFFBSE80UAAFga%2BmSoHprA6BoIFHgJLV6AYABwAABQQBR2ZhcAAAAUxoZnBsMwAAAUdyaWExAAABSG9weAAABgEBAjE1Qks0N0RDSU9GMVNMTFVXOVAAA34AAAAEAAAIVkZPRllQRlFHUktVRFFVWjNGRgAJTFZEQkpBVzhCSTVZU1MxUVVCRwAKAAsBVExPS1dDTDk1UlUwM0Q5UEVURwACNzNHVlREWERFR0UyN00yWEpNVAADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAACAwA%3D" xsd:string {name="markers in reference data on Allen Brain Cell Atlas"} property_value: STATO:0000416 "0.9" xsd:float property_value: STATO:0000663 "0.14610389" xsd:float [Term] id: CLM:5001580 name: Gja1,A330076C08Rik,Itih3,Gria2 (Yao). xref: https://doi.org/10.1038/s41586-023-06812-z is_a: SO:0001260 ! sequence_collection relationship: BFO:0000051 http://identifiers.org/ncbigene/100503592 ! has part A330076C08Rik (Mmus) relationship: BFO:0000051 http://identifiers.org/ncbigene/14609 ! has part Gja1 (Mmus) relationship: BFO:0000051 http://identifiers.org/ncbigene/14800 ! has part Gria2 (Mmus) relationship: BFO:0000051 http://identifiers.org/ncbigene/16426 ! has part Itih3 (Mmus) property_value: CLM:0010004 "0.1" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIBMTE2MCBBc3Ryby1OVCBOTl8yAAABQ0JHQzBVMzBWVjlKUFI2MFRKVQACAAAEAQECgazGjoGWFSADhGpN%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%2BAAAABAAACFZGT0ZZUEZRR1JLVURRVVozRkYACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAVRMT0tXQ0w5NVJVMDNEOVBFVEcAAjczR1ZURFhERUdFMjdNMlhKTVQAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAgMA" xsd:string {name="markers in reference data on Allen Brain Cell Atlas"} property_value: STATO:0000416 "0.90909094" xsd:float property_value: STATO:0000663 "0.3472222" xsd:float [Term] id: CLM:5001581 name: Myoc,Camk2a (Yao). xref: https://doi.org/10.1038/s41586-023-06812-z is_a: SO:0001260 ! sequence_collection relationship: BFO:0000051 http://identifiers.org/ncbigene/12322 ! has part Camk2a (Mmus) relationship: BFO:0000051 http://identifiers.org/ncbigene/17926 ! has part Myoc (Mmus) property_value: CLM:0010004 "0.045" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIBMTE2MSBBc3Ryby1URSBOTl8xAAABQ0JHQzBVMzBWVjlKUFI2MFRKVQACAAAEAQECgazGjoGWFSADhGpN%2FYRYGE0ABQIBTXlvYwAAAUNhbWsyYQAABgEBAjE1Qks0N0RDSU9GMVNMTFVXOVAAA34AAAAEAAAIRzRJNEdGSlhKQjlBVFozUFRYMQAJTFZEQkpBVzhCSTVZU1MxUVVCRwAKAAsBbm9uZQACbm9uZQADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAABSzlKTjIzUDI0S1FDR0s5VTc1QQACSFNZWlBaVzE2NjlVODIxQldZUAADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIBMTE2MSBBc3Ryby1URSBOTl8xAAABQ0JHQzBVMzBWVjlKUFI2MFRKVQACAAAEAQAChFC%2FH4OCCX8DhKAah4TEPdkEMk5RVElFN1RBTVA4UFFBSE80UAAFga%2BmSoHprA6BoIFHgJLV6AYABwAABQIBTXlvYwAAAUNhbWsyYQAABgEBAjE1Qks0N0RDSU9GMVNMTFVXOVAAA34AAAAEAAAIVkZPRllQRlFHUktVRFFVWjNGRgAJTFZEQkpBVzhCSTVZU1MxUVVCRwAKAAsBVExPS1dDTDk1UlUwM0Q5UEVURwACNzNHVlREWERFR0UyN00yWEpNVAADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAACAwA%3D" xsd:string {name="markers in reference data on Allen Brain Cell Atlas"} property_value: STATO:0000416 "1.0" xsd:float property_value: STATO:0000663 "0.19067797" xsd:float [Term] id: CLM:5001582 name: Hepacam,E330013P04Rik (Yao). xref: https://doi.org/10.1038/s41586-023-06812-z is_a: SO:0001260 ! sequence_collection relationship: BFO:0000051 http://identifiers.org/ncbigene/107376 ! has part E330013P04Rik (Mmus) relationship: BFO:0000051 http://identifiers.org/ncbigene/72927 ! has part Hepacam (Mmus) property_value: CLM:0010004 "0.4" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIBMTE2MiBBc3Ryby1URSBOTl8yAAABQ0JHQzBVMzBWVjlKUFI2MFRKVQACAAAEAQECgazGjoGWFSADhGpN%2FYRYGE0ABQIBSGVwYWNhbQAAAUUzMzAwMTNQMDRSaWsAAAYBAQIxNUJLNDdEQ0lPRjFTTExVVzlQAAN%2BAAAABAAACEc0STRHRkpYSkI5QVRaM1BUWDEACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAW5vbmUAAm5vbmUAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAUs5Sk4yM1AyNEtRQ0dLOVU3NUEAAkhTWVpQWlcxNjY5VTgyMUJXWVAAAwQBRlMwMERYVjBUOVIxWDlGSjRRRQACAAABUVk1UzhLTU81SExKVUYwUDAwSwACAAABMTVCSzQ3RENJT0YxU0xMVVc5UAACATExNjIgQXN0cm8tVEUgTk5fMgAAAUNCR0MwVTMwVlY5SlBSNjBUSlUAAgAABAEAAoRQvx%2BDggl%2FA4SgGoeExD3ZBDJOUVRJRTdUQU1QOFBRQUhPNFAABYGvpkqB6awOgaCBR4CS1egGAAcAAAUCAUhlcGFjYW0AAAFFMzMwMDEzUDA0UmlrAAAGAQECMTVCSzQ3RENJT0YxU0xMVVc5UAADfgAAAAQAAAhWRk9GWVBGUUdSS1VEUVVaM0ZGAAlMVkRCSkFXOEJJNVlTUzFRVUJHAAoACwFUTE9LV0NMOTVSVTAzRDlQRVRHAAI3M0dWVERYREVHRTI3TTJYSk1UAAMBBAEAAiMwMDAwMDAAA8gBAAUBAQIjMDAwMDAwAAPIAQAAAAIDAA%3D%3D" xsd:string {name="markers in reference data on Allen Brain Cell Atlas"} property_value: STATO:0000416 "0.6666667" xsd:float property_value: STATO:0000663 "0.5882353" xsd:float [Term] id: CLM:5001583 name: Gja1,Grin2c,Dcc,Slc7a10 (Yao). xref: https://doi.org/10.1038/s41586-023-06812-z is_a: SO:0001260 ! sequence_collection relationship: BFO:0000051 http://identifiers.org/ncbigene/13176 ! has part Dcc (Mmus) relationship: BFO:0000051 http://identifiers.org/ncbigene/14609 ! has part Gja1 (Mmus) relationship: BFO:0000051 http://identifiers.org/ncbigene/14813 ! has part Grin2c (Mmus) relationship: BFO:0000051 http://identifiers.org/ncbigene/53896 ! has part Slc7a10 (Mmus) property_value: CLM:0010004 "0.095" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIBMTE2MyBBc3Ryby1URSBOTl8zAAABQ0JHQzBVMzBWVjlKUFI2MFRKVQACAAAEAQECgazGjoGWFSADhGpN%2FYRYGE0ABQQBR2phMQAAAUdyaW4yYwAAAURjYwAAAVNsYzdhMTAAAAYBAQIxNUJLNDdEQ0lPRjFTTExVVzlQAAN%2BAAAABAAACEc0STRHRkpYSkI5QVRaM1BUWDEACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAW5vbmUAAm5vbmUAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAUs5Sk4yM1AyNEtRQ0dLOVU3NUEAAkhTWVpQWlcxNjY5VTgyMUJXWVAAAwQBRlMwMERYVjBUOVIxWDlGSjRRRQACAAABUVk1UzhLTU81SExKVUYwUDAwSwACAAABMTVCSzQ3RENJT0YxU0xMVVc5UAACATExNjMgQXN0cm8tVEUgTk5fMwAAAUNCR0MwVTMwVlY5SlBSNjBUSlUAAgAABAEAAoRQvx%2BDggl%2FA4SgGoeExD3ZBDJOUVRJRTdUQU1QOFBRQUhPNFAABYGvpkqB6awOgaCBR4CS1egGAAcAAAUEAUdqYTEAAAFHcmluMmMAAAFEY2MAAAFTbGM3YTEwAAAGAQECMTVCSzQ3RENJT0YxU0xMVVc5UAADfgAAAAQAAAhWRk9GWVBGUUdSS1VEUVVaM0ZGAAlMVkRCSkFXOEJJNVlTUzFRVUJHAAoACwFUTE9LV0NMOTVSVTAzRDlQRVRHAAI3M0dWVERYREVHRTI3TTJYSk1UAAMBBAEAAiMwMDAwMDAAA8gBAAUBAQIjMDAwMDAwAAPIAQAAAAIDAA%3D%3D" xsd:string {name="markers in reference data on Allen Brain Cell Atlas"} property_value: STATO:0000416 "0.9047619" xsd:float property_value: STATO:0000663 "0.33450705" xsd:float [Term] id: CLM:5001585 name: Gja1,Thbs4,Kcnk10,Pak1 (Yao). xref: https://doi.org/10.1038/s41586-023-06812-z is_a: SO:0001260 ! sequence_collection relationship: BFO:0000051 http://identifiers.org/ncbigene/14609 ! has part Gja1 (Mmus) relationship: BFO:0000051 http://identifiers.org/ncbigene/18479 ! has part Pak1 (Mmus) relationship: BFO:0000051 http://identifiers.org/ncbigene/21828 ! has part Thbs4 (Mmus) relationship: BFO:0000051 http://identifiers.org/ncbigene/72258 ! has part Kcnk10 (Mmus) property_value: CLM:0010004 "0.01" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIBMTE2NSBBc3Ryby1URSBOTl81AAABQ0JHQzBVMzBWVjlKUFI2MFRKVQACAAAEAQECgazGjoGWFSADhGpN%2FYRYGE0ABQQBR2phMQAAAVRoYnM0AAABS2NuazEwAAABUGFrMQAABgEBAjE1Qks0N0RDSU9GMVNMTFVXOVAAA34AAAAEAAAIRzRJNEdGSlhKQjlBVFozUFRYMQAJTFZEQkpBVzhCSTVZU1MxUVVCRwAKAAsBbm9uZQACbm9uZQADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAABSzlKTjIzUDI0S1FDR0s5VTc1QQACSFNZWlBaVzE2NjlVODIxQldZUAADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIBMTE2NSBBc3Ryby1URSBOTl81AAABQ0JHQzBVMzBWVjlKUFI2MFRKVQACAAAEAQAChFC%2FH4OCCX8DhKAah4TEPdkEMk5RVElFN1RBTVA4UFFBSE80UAAFga%2BmSoHprA6BoIFHgJLV6AYABwAABQQBR2phMQAAAVRoYnM0AAABS2NuazEwAAABUGFrMQAABgEBAjE1Qks0N0RDSU9GMVNMTFVXOVAAA34AAAAEAAAIVkZPRllQRlFHUktVRFFVWjNGRgAJTFZEQkpBVzhCSTVZU1MxUVVCRwAKAAsBVExPS1dDTDk1UlUwM0Q5UEVURwACNzNHVlREWERFR0UyN00yWEpNVAADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAACAwA%3D" xsd:string {name="markers in reference data on Allen Brain Cell Atlas"} property_value: STATO:0000416 "1.0" xsd:float property_value: STATO:0000663 "0.048076924" xsd:float [Term] id: CLM:5001586 name: Aqp4,Prss23,Igfbp2 (Yao). xref: https://doi.org/10.1038/s41586-023-06812-z is_a: SO:0001260 ! 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sequence_collection relationship: BFO:0000051 http://identifiers.org/ncbigene/100504234 ! has part Ccdc170 (Mmus) relationship: BFO:0000051 http://identifiers.org/ncbigene/14765 ! has part Gpr50 (Mmus) relationship: BFO:0000051 http://identifiers.org/ncbigene/228731 ! has part Nkx2-4 (Mmus) property_value: CLM:0010004 "0.1906779661016949" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIBMTE3MyBUYW55Y3l0ZSBOTl8yAAABQ0JHQzBVMzBWVjlKUFI2MFRKVQACAAAEAQECgazGjoGWFSADhGpN%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%2BAAAABAAACFZGT0ZZUEZRR1JLVURRVVozRkYACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAVRMT0tXQ0w5NVJVMDNEOVBFVEcAAjczR1ZURFhERUdFMjdNMlhKTVQAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAgMA" xsd:string {name="markers in reference data on Allen Brain Cell Atlas"} property_value: STATO:0000416 "1.0" xsd:float property_value: STATO:0000663 "0.54086536" xsd:float [Term] id: CLM:5001598 name: 2900040C04Rik (Yao). xref: https://doi.org/10.1038/s41586-023-06812-z is_a: SO:0001260 ! sequence_collection relationship: BFO:0000051 http://identifiers.org/ncbigene/72893 ! has part 2900040C04Rik (Mmus) property_value: CLM:0010004 "0.97" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#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%2BDggl%2FA4SgGoeExD3ZBDJOUVRJRTdUQU1QOFBRQUhPNFAABYGvpkqB6awOgaCBR4CS1egGAAcAAAUBATI5MDAwNDBDMDRSaWsAAAYBAQJRWTVTOEtNTzVITEpVRjBQMDBLAAN%2BAAAABAAACFZGT0ZZUEZRR1JLVURRVVozRkYACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAVRMT0tXQ0w5NVJVMDNEOVBFVEcAAjczR1ZURFhERUdFMjdNMlhKTVQAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAgMA" xsd:string {name="markers in reference data on Allen Brain Cell Atlas"} property_value: STATO:0000416 "1.0" xsd:float property_value: STATO:0000663 "0.99385244" xsd:float [Term] id: CLM:5001601 name: Gpr17,Bmp4 (Yao). xref: https://doi.org/10.1038/s41586-023-06812-z is_a: SO:0001260 ! sequence_collection relationship: BFO:0000051 http://identifiers.org/ncbigene/12159 ! has part Bmp4 (Mmus) relationship: BFO:0000051 http://identifiers.org/ncbigene/574402 ! has part Gpr17 (Mmus) property_value: CLM:0010004 "0.5766666666666667" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#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%2BDggl%2FA4SgGoeExD3ZBDJOUVRJRTdUQU1QOFBRQUhPNFAABYGvpkqB6awOgaCBR4CS1egGAAcAAAUCAUdwcjE3AAABQm1wNAAABgEBAjE1Qks0N0RDSU9GMVNMTFVXOVAAA34AAAAEAAAIVkZPRllQRlFHUktVRFFVWjNGRgAJTFZEQkpBVzhCSTVZU1MxUVVCRwAKAAsBVExPS1dDTDk1UlUwM0Q5UEVURwACNzNHVlREWERFR0UyN00yWEpNVAADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAACAwA%3D" xsd:string {name="markers in reference data on Allen Brain Cell Atlas"} property_value: STATO:0000416 "0.99425286" xsd:float property_value: STATO:0000663 "0.8684739" xsd:float [Term] id: CLM:5001602 name: 9630013A20Rik,Ptprb (Yao). xref: https://doi.org/10.1038/s41586-023-06812-z is_a: SO:0001260 ! sequence_collection relationship: BFO:0000051 http://identifiers.org/ncbigene/19263 ! has part Ptprb (Mmus) relationship: BFO:0000051 http://identifiers.org/ncbigene/319903 ! has part 9630013A20Rik (Mmus) property_value: CLM:0010004 "0.2606060606060606" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIBMTE4MiBORk9MIE5OXzIAAAFDQkdDMFUzMFZWOUpQUjYwVEpVAAIAAAQBAQKBrMaOgZYVIAOEak39hFgYTQAFAgE5NjMwMDEzQTIwUmlrAAABUHRwcmIAAAYBAQIxNUJLNDdEQ0lPRjFTTExVVzlQAAN%2BAAAABAAACEc0STRHRkpYSkI5QVRaM1BUWDEACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAW5vbmUAAm5vbmUAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAUs5Sk4yM1AyNEtRQ0dLOVU3NUEAAkhTWVpQWlcxNjY5VTgyMUJXWVAAAwQBRlMwMERYVjBUOVIxWDlGSjRRRQACAAABUVk1UzhLTU81SExKVUYwUDAwSwACAAABMTVCSzQ3RENJT0YxU0xMVVc5UAACATExODIgTkZPTCBOTl8yAAABQ0JHQzBVMzBWVjlKUFI2MFRKVQACAAAEAQAChFC%2FH4OCCX8DhKAah4TEPdkEMk5RVElFN1RBTVA4UFFBSE80UAAFga%2BmSoHprA6BoIFHgJLV6AYABwAABQIBOTYzMDAxM0EyMFJpawAAAVB0cHJiAAAGAQECMTVCSzQ3RENJT0YxU0xMVVc5UAADfgAAAAQAAAhWRk9GWVBGUUdSS1VEUVVaM0ZGAAlMVkRCSkFXOEJJNVlTUzFRVUJHAAoACwFUTE9LV0NMOTVSVTAzRDlQRVRHAAI3M0dWVERYREVHRTI3TTJYSk1UAAMBBAEAAiMwMDAwMDAAA8gBAAUBAQIjMDAwMDAwAAPIAQAAAAIDAA%3D%3D" xsd:string {name="markers in reference data on Allen Brain Cell Atlas"} property_value: STATO:0000416 "0.97727275" xsd:float property_value: STATO:0000663 "0.6304985" xsd:float [Term] id: CLM:5001603 name: Cldn11,Sec14l5,9630013A20Rik (Yao). xref: https://doi.org/10.1038/s41586-023-06812-z is_a: SO:0001260 ! sequence_collection relationship: BFO:0000051 http://identifiers.org/ncbigene/18417 ! has part Cldn11 (Mmus) relationship: BFO:0000051 http://identifiers.org/ncbigene/319903 ! has part 9630013A20Rik (Mmus) relationship: BFO:0000051 http://identifiers.org/ncbigene/665119 ! has part Sec14l5 (Mmus) property_value: CLM:0010004 "0.17" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#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%3D" xsd:string {name="markers in reference data on Allen Brain Cell Atlas"} property_value: STATO:0000416 "0.9444444" xsd:float property_value: STATO:0000663 "0.49418604" xsd:float [Term] id: CLM:5001604 name: Cldn11,Anln (Yao). xref: https://doi.org/10.1038/s41586-023-06812-z is_a: SO:0001260 ! sequence_collection relationship: BFO:0000051 http://identifiers.org/ncbigene/18417 ! has part Cldn11 (Mmus) relationship: BFO:0000051 http://identifiers.org/ncbigene/68743 ! has part Anln (Mmus) property_value: CLM:0010004 "0.436" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIBMTE4NCBNT0wgTk5fNAAAAUNCR0MwVTMwVlY5SlBSNjBUSlUAAgAABAEBAoGsxo6BlhUgA4RqTf2EWBhNAAUCAUNsZG4xMQAAAUFubG4AAAYBAQIxNUJLNDdEQ0lPRjFTTExVVzlQAAN%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%3D%3D" xsd:string {name="markers in reference data on Allen Brain Cell Atlas"} property_value: STATO:0000416 "0.981982" xsd:float property_value: STATO:0000663 "0.7853026" xsd:float [Term] id: CLM:5001605 name: Apod,Npy (Yao). xref: https://doi.org/10.1038/s41586-023-06812-z is_a: SO:0001260 ! sequence_collection relationship: BFO:0000051 http://identifiers.org/ncbigene/109648 ! has part Npy (Mmus) relationship: BFO:0000051 http://identifiers.org/ncbigene/11815 ! has part Apod (Mmus) property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIBMzIgT0VDAAABUVk1UzhLTU81SExKVUYwUDAwSwACAAABMTVCSzQ3RENJT0YxU0xMVVc5UAACAAABQ0JHQzBVMzBWVjlKUFI2MFRKVQACAAAEAQECgazGjoGWFSADhGpN%2FYRYGE0ABQIBQXBvZAAAAU5weQAABgEBAkZTMDBEWFYwVDlSMVg5Rko0UUUAA34AAAAEAAAIRzRJNEdGSlhKQjlBVFozUFRYMQAJTFZEQkpBVzhCSTVZU1MxUVVCRwAKAAsBbm9uZQACbm9uZQADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAABSzlKTjIzUDI0S1FDR0s5VTc1QQACSFNZWlBaVzE2NjlVODIxQldZUAADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIBMzIgT0VDAAABUVk1UzhLTU81SExKVUYwUDAwSwACAAABMTVCSzQ3RENJT0YxU0xMVVc5UAACAAABQ0JHQzBVMzBWVjlKUFI2MFRKVQACAAAEAQAChFC%2FH4OCCX8DhKAah4TEPdkEMk5RVElFN1RBTVA4UFFBSE80UAAFga%2BmSoHprA6BoIFHgJLV6AYABwAABQIBQXBvZAAAAU5weQAABgEBAkZTMDBEWFYwVDlSMVg5Rko0UUUAA34AAAAEAAAIVkZPRllQRlFHUktVRFFVWjNGRgAJTFZEQkpBVzhCSTVZU1MxUVVCRwAKAAsBVExPS1dDTDk1UlUwM0Q5UEVURwACNzNHVlREWERFR0UyN00yWEpNVAADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAACAwA%3D" xsd:string {name="markers in reference data on Allen Brain Cell Atlas"} [Term] id: CLM:5001606 name: Thbd,Ccn3 (Yao). xref: https://doi.org/10.1038/s41586-023-06812-z is_a: SO:0001260 ! sequence_collection relationship: BFO:0000051 http://identifiers.org/ncbigene/18133 ! has part Ccn3 (Mmus) relationship: BFO:0000051 http://identifiers.org/ncbigene/21824 ! has part Thbd (Mmus) property_value: CLM:0010004 "0.7533333333333333" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#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%2FH4OCCX8DhKAah4TEPdkEMk5RVElFN1RBTVA4UFFBSE80UAAFga%2BmSoHprA6BoIFHgJLV6AYABwAABQIBVGhiZAAAAUNjbjMAAAYBAQJRWTVTOEtNTzVITEpVRjBQMDBLAAN%2BAAAABAAACFZGT0ZZUEZRR1JLVURRVVozRkYACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAVRMT0tXQ0w5NVJVMDNEOVBFVEcAAjczR1ZURFhERUdFMjdNMlhKTVQAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAgMA" xsd:string {name="markers in reference data on Allen Brain Cell Atlas"} property_value: STATO:0000416 "0.94166666" xsd:float property_value: STATO:0000663 "0.8968254" xsd:float [Term] id: CLM:5001615 name: Mrc1,Maf (Yao). xref: https://doi.org/10.1038/s41586-023-06812-z is_a: SO:0001260 ! sequence_collection relationship: BFO:0000051 http://identifiers.org/ncbigene/17132 ! has part Maf (Mmus) relationship: BFO:0000051 http://identifiers.org/ncbigene/17533 ! has part Mrc1 (Mmus) property_value: CLM:0010004 "0.71" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIBMzM1IEJBTSBOTgAAATE1Qks0N0RDSU9GMVNMTFVXOVAAAgAAAUNCR0MwVTMwVlY5SlBSNjBUSlUAAgAABAEBAoGsxo6BlhUgA4RqTf2EWBhNAAUCAU1yYzEAAAFNYWYAAAYBAQJRWTVTOEtNTzVITEpVRjBQMDBLAAN%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%3D%3D" xsd:string {name="markers in reference data on Allen Brain Cell Atlas"} property_value: STATO:0000416 "1.0" xsd:float property_value: STATO:0000663 "0.9244792" xsd:float [Term] id: CLM:5004314 name: Gnrh1 (Yao). xref: https://doi.org/10.1038/s41586-023-06812-z is_a: SO:0001260 ! sequence_collection relationship: BFO:0000051 http://identifiers.org/ncbigene/14714 ! has part Gnrh1 (Mmus) property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#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%2FH4OCCX8DhKAah4TEPdkEMk5RVElFN1RBTVA4UFFBSE80UAAFga%2BmSoHprA6BoIFHgJLV6AYABwAABQEBR25yaDEAAAYBAQJGUzAwRFhWMFQ5UjFYOUZKNFFFAAN%2BAAAABAAACFZGT0ZZUEZRR1JLVURRVVozRkYACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAVRMT0tXQ0w5NVJVMDNEOVBFVEcAAjczR1ZURFhERUdFMjdNMlhKTVQAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAgMA" xsd:string {name="markers in reference data on Allen Brain Cell Atlas"} [Term] id: CLM:5006356 name: Cngb3,Ush2a (Yao). xref: https://doi.org/10.1038/s41586-023-06812-z is_a: SO:0001260 ! sequence_collection relationship: BFO:0000051 http://identifiers.org/ncbigene/22283 ! has part Ush2a (Mmus) relationship: BFO:0000051 http://identifiers.org/ncbigene/30952 ! has part Cngb3 (Mmus) property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#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%2BDggl%2FA4SgGoeExD3ZBDJOUVRJRTdUQU1QOFBRQUhPNFAABYGvpkqB6awOgaCBR4CS1egGAAcAAAUCAUNuZ2IzAAABVXNoMmEAAAYBAQJGUzAwRFhWMFQ5UjFYOUZKNFFFAAN%2BAAAABAAACFZGT0ZZUEZRR1JLVURRVVozRkYACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAVRMT0tXQ0w5NVJVMDNEOVBFVEcAAjczR1ZURFhERUdFMjdNMlhKTVQAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAgMA" xsd:string {name="markers in reference data on Allen Brain Cell Atlas"} [Term] id: CLM:5006922 name: Il22,Edaradd (Yao). xref: https://doi.org/10.1038/s41586-023-06812-z is_a: SO:0001260 ! sequence_collection relationship: BFO:0000051 http://identifiers.org/ncbigene/171211 ! has part Edaradd (Mmus) relationship: BFO:0000051 http://identifiers.org/ncbigene/50929 ! has part Il22 (Mmus) property_value: CLM:0010004 "0.72" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIAAAFDQkdDMFUzMFZWOUpQUjYwVEpVAAIBNTE3MiBEQ08gSWwyMiBHbHktR2FiYV8yAAAEAQECgazGjoGWFSADhGpN%2FYRYGE0ABQIBSWwyMgAAAUVkYXJhZGQAAAYBAQJDQkdDMFUzMFZWOUpQUjYwVEpVAAN%2BAAAABAAACEc0STRHRkpYSkI5QVRaM1BUWDEACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAW5vbmUAAm5vbmUAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAUs5Sk4yM1AyNEtRQ0dLOVU3NUEAAkhTWVpQWlcxNjY5VTgyMUJXWVAAAwQBRlMwMERYVjBUOVIxWDlGSjRRRQACAAABUVk1UzhLTU81SExKVUYwUDAwSwACAAABMTVCSzQ3RENJT0YxU0xMVVc5UAACAAABQ0JHQzBVMzBWVjlKUFI2MFRKVQACATUxNzIgRENPIElsMjIgR2x5LUdhYmFfMgAABAEAAoRQvx%2BDggl%2FA4SgGoeExD3ZBDJOUVRJRTdUQU1QOFBRQUhPNFAABYGvpkqB6awOgaCBR4CS1egGAAcAAAUCAUlsMjIAAAFFZGFyYWRkAAAGAQECQ0JHQzBVMzBWVjlKUFI2MFRKVQADfgAAAAQAAAhWRk9GWVBGUUdSS1VEUVVaM0ZGAAlMVkRCSkFXOEJJNVlTUzFRVUJHAAoACwFUTE9LV0NMOTVSVTAzRDlQRVRHAAI3M0dWVERYREVHRTI3TTJYSk1UAAMBBAEAAiMwMDAwMDAAA8gBAAUBAQIjMDAwMDAwAAPIAQAAAAIDAA%3D%3D" xsd:string {name="markers in reference data on Allen Brain Cell Atlas"} property_value: STATO:0000416 "0.94736844" xsd:float property_value: STATO:0000663 "0.8910891" xsd:float [Term] id: CLM:5006935 name: Ly6d,Kit (Yao). xref: https://doi.org/10.1038/s41586-023-06812-z is_a: SO:0001260 ! sequence_collection relationship: BFO:0000051 http://identifiers.org/ncbigene/16590 ! has part Kit (Mmus) relationship: BFO:0000051 http://identifiers.org/ncbigene/17068 ! has part Ly6d (Mmus) property_value: CLM:0010004 "0.48" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIAAAFDQkdDMFUzMFZWOUpQUjYwVEpVAAIBNTE4NSBDQiBQTEkgR2x5LUdhYmFfNAAABAEBAoGsxo6BlhUgA4RqTf2EWBhNAAUCAUx5NmQAAAFLaXQAAAYBAQJDQkdDMFUzMFZWOUpQUjYwVEpVAAN%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%3D%3D" xsd:string {name="markers in reference data on Allen Brain Cell Atlas"} property_value: STATO:0000416 "0.96" xsd:float property_value: STATO:0000663 "0.8" xsd:float [Term] id: CLM:5006942 name: Cdh1,Acvr1c,Adamts15,Pax2 (Yao). xref: https://doi.org/10.1038/s41586-023-06812-z is_a: SO:0001260 ! sequence_collection relationship: BFO:0000051 http://identifiers.org/ncbigene/12550 ! has part Cdh1 (Mmus) relationship: BFO:0000051 http://identifiers.org/ncbigene/18504 ! has part Pax2 (Mmus) relationship: BFO:0000051 http://identifiers.org/ncbigene/235130 ! has part Adamts15 (Mmus) relationship: BFO:0000051 http://identifiers.org/ncbigene/269275 ! has part Acvr1c (Mmus) property_value: CLM:0010004 "0.26" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIBMzEyIENCWCBNTEkgQ2RoMjIgR2FiYQAAATE1Qks0N0RDSU9GMVNMTFVXOVAAAgAAAUNCR0MwVTMwVlY5SlBSNjBUSlUAAgAABAEBAoGsxo6BlhUgA4RqTf2EWBhNAAUEAUNkaDEAAAFBY3ZyMWMAAAFBZGFtdHMxNQAAAVBheDIAAAYBAQJRWTVTOEtNTzVITEpVRjBQMDBLAAN%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%3D%3D" xsd:string {name="markers in reference data on Allen Brain Cell Atlas"} property_value: STATO:0000416 "0.9285714" xsd:float property_value: STATO:0000663 "0.6132075" xsd:float [Term] id: CLM:5006956 name: Gpr37l1,Ctxn3 (Yao). xref: https://doi.org/10.1038/s41586-023-06812-z is_a: SO:0001260 ! sequence_collection relationship: BFO:0000051 http://identifiers.org/ncbigene/171469 ! has part Gpr37l1 (Mmus) relationship: BFO:0000051 http://identifiers.org/ncbigene/629147 ! has part Ctxn3 (Mmus) property_value: CLM:0010004 "0.62" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIBMzE2IEJlcmdtYW5uIE5OAAABMTVCSzQ3RENJT0YxU0xMVVc5UAACAAABQ0JHQzBVMzBWVjlKUFI2MFRKVQACAAAEAQECgazGjoGWFSADhGpN%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%2BAAAABAAACFZGT0ZZUEZRR1JLVURRVVozRkYACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAVRMT0tXQ0w5NVJVMDNEOVBFVEcAAjczR1ZURFhERUdFMjdNMlhKTVQAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAgMA" xsd:string {name="markers in reference data on Allen Brain Cell Atlas"} property_value: STATO:0000416 "1.0" xsd:float property_value: STATO:0000663 "0.8908046" xsd:float [Term] id: CLM:5006957 name: Dao,Efemp1 (Yao). xref: https://doi.org/10.1038/s41586-023-06812-z is_a: SO:0001260 ! sequence_collection relationship: BFO:0000051 http://identifiers.org/ncbigene/13142 ! has part Dao (Mmus) relationship: BFO:0000051 http://identifiers.org/ncbigene/216616 ! has part Efemp1 (Mmus) property_value: CLM:0010004 "0.44" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIBMzE3IEFzdHJvLUNCIE5OAAABMTVCSzQ3RENJT0YxU0xMVVc5UAACAAABQ0JHQzBVMzBWVjlKUFI2MFRKVQACAAAEAQECgazGjoGWFSADhGpN%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%2BAAAABAAACFZGT0ZZUEZRR1JLVURRVVozRkYACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAVRMT0tXQ0w5NVJVMDNEOVBFVEcAAjczR1ZURFhERUdFMjdNMlhKTVQAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAgMA" xsd:string {name="markers in reference data on Allen Brain Cell Atlas"} property_value: STATO:0000416 "0.7096774" xsd:float property_value: STATO:0000663 "0.6321839" xsd:float [Term] id: CLM:5006958 name: Gfap,Galnt15,Agt (Yao). xref: https://doi.org/10.1038/s41586-023-06812-z is_a: SO:0001260 ! sequence_collection relationship: BFO:0000051 http://identifiers.org/ncbigene/11606 ! has part Agt (Mmus) relationship: BFO:0000051 http://identifiers.org/ncbigene/14580 ! has part Gfap (Mmus) relationship: BFO:0000051 http://identifiers.org/ncbigene/78754 ! has part Galnt15 (Mmus) property_value: CLM:0010004 "0.08" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIAAAFDQkdDMFUzMFZWOUpQUjYwVEpVAAIBNTIwOCBBc3Ryby1OVCBOTl8xAAAEAQECgazGjoGWFSADhGpN%2FYRYGE0ABQMBR2ZhcAAAAUdhbG50MTUAAAFBZ3QAAAYBAQJDQkdDMFUzMFZWOUpQUjYwVEpVAAN%2BAAAABAAACEc0STRHRkpYSkI5QVRaM1BUWDEACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAW5vbmUAAm5vbmUAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAUs5Sk4yM1AyNEtRQ0dLOVU3NUEAAkhTWVpQWlcxNjY5VTgyMUJXWVAAAwQBRlMwMERYVjBUOVIxWDlGSjRRRQACAAABUVk1UzhLTU81SExKVUYwUDAwSwACAAABMTVCSzQ3RENJT0YxU0xMVVc5UAACAAABQ0JHQzBVMzBWVjlKUFI2MFRKVQACATUyMDggQXN0cm8tTlQgTk5fMQAABAEAAoRQvx%2BDggl%2FA4SgGoeExD3ZBDJOUVRJRTdUQU1QOFBRQUhPNFAABYGvpkqB6awOgaCBR4CS1egGAAcAAAUDAUdmYXAAAAFHYWxudDE1AAABQWd0AAAGAQECQ0JHQzBVMzBWVjlKUFI2MFRKVQADfgAAAAQAAAhWRk9GWVBGUUdSS1VEUVVaM0ZGAAlMVkRCSkFXOEJJNVlTUzFRVUJHAAoACwFUTE9LV0NMOTVSVTAzRDlQRVRHAAI3M0dWVERYREVHRTI3TTJYSk1UAAMBBAEAAiMwMDAwMDAAA8gBAAUBAQIjMDAwMDAwAAPIAQAAAAIDAA%3D%3D" xsd:string {name="markers in reference data on Allen Brain Cell Atlas"} property_value: STATO:0000416 "1.0" xsd:float property_value: STATO:0000663 "0.3030303" xsd:float [Term] id: CLM:5006959 name: Gfap,Slc36a2,Sfrp5 (Yao). xref: https://doi.org/10.1038/s41586-023-06812-z is_a: SO:0001260 ! sequence_collection relationship: BFO:0000051 http://identifiers.org/ncbigene/14580 ! has part Gfap (Mmus) relationship: BFO:0000051 http://identifiers.org/ncbigene/246049 ! has part Slc36a2 (Mmus) relationship: BFO:0000051 http://identifiers.org/ncbigene/54612 ! has part Sfrp5 (Mmus) property_value: CLM:0010004 "0.1" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIAAAFDQkdDMFUzMFZWOUpQUjYwVEpVAAIBNTIwOSBBc3Ryby1OVCBOTl8xAAAEAQECgazGjoGWFSADhGpN%2FYRYGE0ABQMBR2ZhcAAAAVNsYzM2YTIAAAFTZnJwNQAABgEBAkNCR0MwVTMwVlY5SlBSNjBUSlUAA34AAAAEAAAIRzRJNEdGSlhKQjlBVFozUFRYMQAJTFZEQkpBVzhCSTVZU1MxUVVCRwAKAAsBbm9uZQACbm9uZQADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAABSzlKTjIzUDI0S1FDR0s5VTc1QQACSFNZWlBaVzE2NjlVODIxQldZUAADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIAAAFDQkdDMFUzMFZWOUpQUjYwVEpVAAIBNTIwOSBBc3Ryby1OVCBOTl8xAAAEAQAChFC%2FH4OCCX8DhKAah4TEPdkEMk5RVElFN1RBTVA4UFFBSE80UAAFga%2BmSoHprA6BoIFHgJLV6AYABwAABQMBR2ZhcAAAAVNsYzM2YTIAAAFTZnJwNQAABgEBAkNCR0MwVTMwVlY5SlBSNjBUSlUAA34AAAAEAAAIVkZPRllQRlFHUktVRFFVWjNGRgAJTFZEQkpBVzhCSTVZU1MxUVVCRwAKAAsBVExPS1dDTDk1UlUwM0Q5UEVURwACNzNHVlREWERFR0UyN00yWEpNVAADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAACAwA%3D" xsd:string {name="markers in reference data on Allen Brain Cell Atlas"} property_value: STATO:0000416 "1.0" xsd:float property_value: STATO:0000663 "0.35714287" xsd:float [Term] id: CLM:5006960 name: Gfap,Sfrp5,Cldn10,Riiad1 (Yao). xref: https://doi.org/10.1038/s41586-023-06812-z is_a: SO:0001260 ! sequence_collection relationship: BFO:0000051 http://identifiers.org/ncbigene/14580 ! has part Gfap (Mmus) relationship: BFO:0000051 http://identifiers.org/ncbigene/54612 ! has part Sfrp5 (Mmus) relationship: BFO:0000051 http://identifiers.org/ncbigene/58187 ! has part Cldn10 (Mmus) relationship: BFO:0000051 http://identifiers.org/ncbigene/66353 ! has part Riiad1 (Mmus) property_value: CLM:0010004 "0.08" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIAAAFDQkdDMFUzMFZWOUpQUjYwVEpVAAIBNTIxMCBBc3Ryby1OVCBOTl8xAAAEAQECgazGjoGWFSADhGpN%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%2BAAAABAAACFZGT0ZZUEZRR1JLVURRVVozRkYACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAVRMT0tXQ0w5NVJVMDNEOVBFVEcAAjczR1ZURFhERUdFMjdNMlhKTVQAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAgMA" xsd:string {name="markers in reference data on Allen Brain Cell Atlas"} property_value: STATO:0000416 "0.6666667" xsd:float property_value: STATO:0000663 "0.27027026" xsd:float [Term] id: CLM:5006961 name: Myoc,Six3os1,Slc36a2 (Yao). xref: https://doi.org/10.1038/s41586-023-06812-z is_a: SO:0001260 ! sequence_collection relationship: BFO:0000051 http://identifiers.org/ncbigene/100043902 ! has part Six3os1 (Mmus) relationship: BFO:0000051 http://identifiers.org/ncbigene/17926 ! has part Myoc (Mmus) relationship: BFO:0000051 http://identifiers.org/ncbigene/246049 ! has part Slc36a2 (Mmus) property_value: CLM:0010004 "0.08" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIAAAFDQkdDMFUzMFZWOUpQUjYwVEpVAAIBNTIxMSBBc3Ryby1OVCBOTl8xAAAEAQECgazGjoGWFSADhGpN%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%2BAAAABAAACFZGT0ZZUEZRR1JLVURRVVozRkYACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAVRMT0tXQ0w5NVJVMDNEOVBFVEcAAjczR1ZURFhERUdFMjdNMlhKTVQAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAgMA" xsd:string {name="markers in reference data on Allen Brain Cell Atlas"} property_value: STATO:0000416 "1.0" xsd:float property_value: STATO:0000663 "0.3030303" xsd:float [Term] id: CLM:5006962 name: Agt,Prss35,C4b (Yao). xref: https://doi.org/10.1038/s41586-023-06812-z is_a: SO:0001260 ! 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sequence_collection relationship: BFO:0000051 http://identifiers.org/ncbigene/100503592 ! has part A330076C08Rik (Mmus) relationship: BFO:0000051 http://identifiers.org/ncbigene/14609 ! has part Gja1 (Mmus) relationship: BFO:0000051 http://identifiers.org/ncbigene/18424 ! has part Otx2 (Mmus) relationship: BFO:0000051 http://identifiers.org/ncbigene/208898 ! has part Unc13c (Mmus) property_value: CLM:0010004 "0.06" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIAAAFDQkdDMFUzMFZWOUpQUjYwVEpVAAIBNTIxNSBBc3Ryby1OVCBOTl8yAAAEAQECgazGjoGWFSADhGpN%2FYRYGE0ABQQBR2phMQAAAUEzMzAwNzZDMDhSaWsAAAFPdHgyAAABVW5jMTNjAAAGAQECQ0JHQzBVMzBWVjlKUFI2MFRKVQADfgAAAAQAAAhHNEk0R0ZKWEpCOUFUWjNQVFgxAAlMVkRCSkFXOEJJNVlTUzFRVUJHAAoACwFub25lAAJub25lAAMBBAEAAiMwMDAwMDAAA8gBAAUBAQIjMDAwMDAwAAPIAQAAAAFLOUpOMjNQMjRLUUNHSzlVNzVBAAJIU1laUFpXMTY2OVU4MjFCV1lQAAMEAUZTMDBEWFYwVDlSMVg5Rko0UUUAAgAAAVFZNVM4S01PNUhMSlVGMFAwMEsAAgAAATE1Qks0N0RDSU9GMVNMTFVXOVAAAgAAAUNCR0MwVTMwVlY5SlBSNjBUSlUAAgE1MjE1IEFzdHJvLU5UIE5OXzIAAAQBAAKEUL8fg4IJfwOEoBqHhMQ92QQyTlFUSUU3VEFNUDhQUUFITzRQAAWBr6ZKgemsDoGggUeAktXoBgAHAAAFBAFHamExAAABQTMzMDA3NkMwOFJpawAAAU90eDIAAAFVbmMxM2MAAAYBAQJDQkdDMFUzMFZWOUpQUjYwVEpVAAN%2BAAAABAAACFZGT0ZZUEZRR1JLVURRVVozRkYACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAVRMT0tXQ0w5NVJVMDNEOVBFVEcAAjczR1ZURFhERUdFMjdNMlhKTVQAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAgMA" xsd:string {name="markers in reference data on Allen Brain Cell Atlas"} property_value: STATO:0000416 "1.0" xsd:float property_value: STATO:0000663 "0.24193548" xsd:float [Term] id: CLM:5006966 name: Slc7a10,Cyp26b1,Igfbp2,Shroom3 (Yao). xref: https://doi.org/10.1038/s41586-023-06812-z is_a: SO:0001260 ! 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sequence_collection relationship: BFO:0000051 http://identifiers.org/ncbigene/100503592 ! has part A330076C08Rik (Mmus) relationship: BFO:0000051 http://identifiers.org/ncbigene/11829 ! has part Aqp4 (Mmus) relationship: BFO:0000051 http://identifiers.org/ncbigene/23876 ! has part Fbln5 (Mmus) relationship: BFO:0000051 http://identifiers.org/ncbigene/320772 ! has part Mdga2 (Mmus) property_value: CLM:0010004 "0.02" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIAAAFDQkdDMFUzMFZWOUpQUjYwVEpVAAIBNTIxNyBBc3Ryby1OVCBOTl8yAAAEAQECgazGjoGWFSADhGpN%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%2BAAAABAAACFZGT0ZZUEZRR1JLVURRVVozRkYACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAVRMT0tXQ0w5NVJVMDNEOVBFVEcAAjczR1ZURFhERUdFMjdNMlhKTVQAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAgMA" xsd:string {name="markers in reference data on Allen Brain Cell Atlas"} property_value: STATO:0000416 "1.0" xsd:float property_value: STATO:0000663 "0.09259259" xsd:float [Term] id: CLM:5006968 name: Myoc,Lhx2,Kcne1l,Alpk1 (Yao). xref: https://doi.org/10.1038/s41586-023-06812-z is_a: SO:0001260 ! 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sequence_collection relationship: BFO:0000051 http://identifiers.org/ncbigene/17926 ! has part Myoc (Mmus) relationship: BFO:0000051 http://identifiers.org/ncbigene/20743 ! has part Sptbn2 (Mmus) relationship: BFO:0000051 http://identifiers.org/ncbigene/71481 ! has part Alpk1 (Mmus) property_value: CLM:0010004 "0.1" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIAAAFDQkdDMFUzMFZWOUpQUjYwVEpVAAIBNTIyMSBBc3Ryby1URSBOTl8xAAAEAQECgazGjoGWFSADhGpN%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%2BAAAABAAACFZGT0ZZUEZRR1JLVURRVVozRkYACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAVRMT0tXQ0w5NVJVMDNEOVBFVEcAAjczR1ZURFhERUdFMjdNMlhKTVQAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAgMA" xsd:string {name="markers in reference data on Allen Brain Cell Atlas"} property_value: STATO:0000416 "0.45454547" xsd:float property_value: STATO:0000663 "0.26595744" xsd:float [Term] id: CLM:5006972 name: Gm6145,E330013P04Rik,Slc39a12 (Yao). xref: https://doi.org/10.1038/s41586-023-06812-z is_a: SO:0001260 ! 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sequence_collection relationship: BFO:0000051 http://identifiers.org/ncbigene/13649 ! has part Egfr (Mmus) relationship: BFO:0000051 http://identifiers.org/ncbigene/17219 ! has part Mcm6 (Mmus) relationship: BFO:0000051 http://identifiers.org/ncbigene/18553 ! has part Pcsk6 (Mmus) property_value: CLM:0010004 "0.1" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIAAAFDQkdDMFUzMFZWOUpQUjYwVEpVAAIBNTIyMyBBc3Ryby1URSBOTl8yAAAEAQECgazGjoGWFSADhGpN%2FYRYGE0ABQMBTWNtNgAAAUVnZnIAAAFQY3NrNgAABgEBAkNCR0MwVTMwVlY5SlBSNjBUSlUAA34AAAAEAAAIRzRJNEdGSlhKQjlBVFozUFRYMQAJTFZEQkpBVzhCSTVZU1MxUVVCRwAKAAsBbm9uZQACbm9uZQADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAABSzlKTjIzUDI0S1FDR0s5VTc1QQACSFNZWlBaVzE2NjlVODIxQldZUAADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIAAAFDQkdDMFUzMFZWOUpQUjYwVEpVAAIBNTIyMyBBc3Ryby1URSBOTl8yAAAEAQAChFC%2FH4OCCX8DhKAah4TEPdkEMk5RVElFN1RBTVA4UFFBSE80UAAFga%2BmSoHprA6BoIFHgJLV6AYABwAABQMBTWNtNgAAAUVnZnIAAAFQY3NrNgAABgEBAkNCR0MwVTMwVlY5SlBSNjBUSlUAA34AAAAEAAAIVkZPRllQRlFHUktVRFFVWjNGRgAJTFZEQkpBVzhCSTVZU1MxUVVCRwAKAAsBVExPS1dDTDk1UlUwM0Q5UEVURwACNzNHVlREWERFR0UyN00yWEpNVAADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAACAwA%3D" xsd:string {name="markers in reference data on Allen Brain Cell Atlas"} property_value: STATO:0000416 "0.5" xsd:float property_value: STATO:0000663 "0.2777778" xsd:float [Term] id: CLM:5006974 name: Gja1,Cxcl5,Ddn (Yao). xref: https://doi.org/10.1038/s41586-023-06812-z is_a: SO:0001260 ! sequence_collection relationship: BFO:0000051 http://identifiers.org/ncbigene/13199 ! has part Ddn (Mmus) relationship: BFO:0000051 http://identifiers.org/ncbigene/14609 ! has part Gja1 (Mmus) relationship: BFO:0000051 http://identifiers.org/ncbigene/20311 ! has part Cxcl5 (Mmus) property_value: CLM:0010004 "0.0" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIAAAFDQkdDMFUzMFZWOUpQUjYwVEpVAAIBNTIyNCBBc3Ryby1URSBOTl8zAAAEAQECgazGjoGWFSADhGpN%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%2BAAAABAAACFZGT0ZZUEZRR1JLVURRVVozRkYACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAVRMT0tXQ0w5NVJVMDNEOVBFVEcAAjczR1ZURFhERUdFMjdNMlhKTVQAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAgMA" xsd:string {name="markers in reference data on Allen Brain Cell Atlas"} property_value: STATO:0000416 "0.0" xsd:float property_value: STATO:0000663 "0.0" xsd:float [Term] id: CLM:5006975 name: S1pr1,Fam163a,Kcnq3,Kcnq1ot1 (Yao). xref: https://doi.org/10.1038/s41586-023-06812-z is_a: SO:0001260 ! sequence_collection relationship: BFO:0000051 http://identifiers.org/ncbigene/110862 ! has part Kcnq3 (Mmus) relationship: BFO:0000051 http://identifiers.org/ncbigene/13609 ! has part S1pr1 (Mmus) relationship: BFO:0000051 http://identifiers.org/ncbigene/329274 ! has part Fam163a (Mmus) relationship: BFO:0000051 http://identifiers.org/ncbigene/63830 ! has part Kcnq1ot1 (Mmus) property_value: CLM:0010004 "0.02" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIAAAFDQkdDMFUzMFZWOUpQUjYwVEpVAAIBNTIyNSBBc3Ryby1URSBOTl8zAAAEAQECgazGjoGWFSADhGpN%2FYRYGE0ABQQBUzFwcjEAAAFGYW0xNjNhAAABS2NucTMAAAFLY25xMW90MQAABgEBAkNCR0MwVTMwVlY5SlBSNjBUSlUAA34AAAAEAAAIRzRJNEdGSlhKQjlBVFozUFRYMQAJTFZEQkpBVzhCSTVZU1MxUVVCRwAKAAsBbm9uZQACbm9uZQADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAABSzlKTjIzUDI0S1FDR0s5VTc1QQACSFNZWlBaVzE2NjlVODIxQldZUAADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIAAAFDQkdDMFUzMFZWOUpQUjYwVEpVAAIBNTIyNSBBc3Ryby1URSBOTl8zAAAEAQAChFC%2FH4OCCX8DhKAah4TEPdkEMk5RVElFN1RBTVA4UFFBSE80UAAFga%2BmSoHprA6BoIFHgJLV6AYABwAABQQBUzFwcjEAAAFGYW0xNjNhAAABS2NucTMAAAFLY25xMW90MQAABgEBAkNCR0MwVTMwVlY5SlBSNjBUSlUAA34AAAAEAAAIVkZPRllQRlFHUktVRFFVWjNGRgAJTFZEQkpBVzhCSTVZU1MxUVVCRwAKAAsBVExPS1dDTDk1UlUwM0Q5UEVURwACNzNHVlREWERFR0UyN00yWEpNVAADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAACAwA%3D" xsd:string {name="markers in reference data on Allen Brain Cell Atlas"} property_value: STATO:0000416 "0.5" xsd:float property_value: STATO:0000663 "0.0862069" xsd:float [Term] id: CLM:5006976 name: S1pr1,Ranbp3l,Emx2os,Zic4 (Yao). xref: https://doi.org/10.1038/s41586-023-06812-z is_a: SO:0001260 ! sequence_collection relationship: BFO:0000051 http://identifiers.org/ncbigene/13609 ! has part S1pr1 (Mmus) relationship: BFO:0000051 http://identifiers.org/ncbigene/223332 ! has part Ranbp3l (Mmus) relationship: BFO:0000051 http://identifiers.org/ncbigene/22774 ! has part Zic4 (Mmus) relationship: BFO:0000051 http://identifiers.org/ncbigene/329078 ! has part Emx2os (Mmus) property_value: CLM:0010004 "0.0" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIAAAFDQkdDMFUzMFZWOUpQUjYwVEpVAAIBNTIyNiBBc3Ryby1URSBOTl8zAAAEAQECgazGjoGWFSADhGpN%2FYRYGE0ABQQBUzFwcjEAAAFSYW5icDNsAAABRW14Mm9zAAABWmljNAAABgEBAkNCR0MwVTMwVlY5SlBSNjBUSlUAA34AAAAEAAAIRzRJNEdGSlhKQjlBVFozUFRYMQAJTFZEQkpBVzhCSTVZU1MxUVVCRwAKAAsBbm9uZQACbm9uZQADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAABSzlKTjIzUDI0S1FDR0s5VTc1QQACSFNZWlBaVzE2NjlVODIxQldZUAADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIAAAFDQkdDMFUzMFZWOUpQUjYwVEpVAAIBNTIyNiBBc3Ryby1URSBOTl8zAAAEAQAChFC%2FH4OCCX8DhKAah4TEPdkEMk5RVElFN1RBTVA4UFFBSE80UAAFga%2BmSoHprA6BoIFHgJLV6AYABwAABQQBUzFwcjEAAAFSYW5icDNsAAABRW14Mm9zAAABWmljNAAABgEBAkNCR0MwVTMwVlY5SlBSNjBUSlUAA34AAAAEAAAIVkZPRllQRlFHUktVRFFVWjNGRgAJTFZEQkpBVzhCSTVZU1MxUVVCRwAKAAsBVExPS1dDTDk1UlUwM0Q5UEVURwACNzNHVlREWERFR0UyN00yWEpNVAADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAACAwA%3D" xsd:string {name="markers in reference data on Allen Brain Cell Atlas"} property_value: STATO:0000416 "0.0" xsd:float property_value: STATO:0000663 "0.0" xsd:float [Term] id: CLM:5006977 name: S1pr1,Crym,Grin2c (Yao). xref: https://doi.org/10.1038/s41586-023-06812-z is_a: SO:0001260 ! sequence_collection relationship: BFO:0000051 http://identifiers.org/ncbigene/12971 ! has part Crym (Mmus) relationship: BFO:0000051 http://identifiers.org/ncbigene/13609 ! has part S1pr1 (Mmus) relationship: BFO:0000051 http://identifiers.org/ncbigene/14813 ! has part Grin2c (Mmus) property_value: CLM:0010004 "0.0" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIAAAFDQkdDMFUzMFZWOUpQUjYwVEpVAAIBNTIyNyBBc3Ryby1URSBOTl8zAAAEAQECgazGjoGWFSADhGpN%2FYRYGE0ABQMBUzFwcjEAAAFDcnltAAABR3JpbjJjAAAGAQECQ0JHQzBVMzBWVjlKUFI2MFRKVQADfgAAAAQAAAhHNEk0R0ZKWEpCOUFUWjNQVFgxAAlMVkRCSkFXOEJJNVlTUzFRVUJHAAoACwFub25lAAJub25lAAMBBAEAAiMwMDAwMDAAA8gBAAUBAQIjMDAwMDAwAAPIAQAAAAFLOUpOMjNQMjRLUUNHSzlVNzVBAAJIU1laUFpXMTY2OVU4MjFCV1lQAAMEAUZTMDBEWFYwVDlSMVg5Rko0UUUAAgAAAVFZNVM4S01PNUhMSlVGMFAwMEsAAgAAATE1Qks0N0RDSU9GMVNMTFVXOVAAAgAAAUNCR0MwVTMwVlY5SlBSNjBUSlUAAgE1MjI3IEFzdHJvLVRFIE5OXzMAAAQBAAKEUL8fg4IJfwOEoBqHhMQ92QQyTlFUSUU3VEFNUDhQUUFITzRQAAWBr6ZKgemsDoGggUeAktXoBgAHAAAFAwFTMXByMQAAAUNyeW0AAAFHcmluMmMAAAYBAQJDQkdDMFUzMFZWOUpQUjYwVEpVAAN%2BAAAABAAACFZGT0ZZUEZRR1JLVURRVVozRkYACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAVRMT0tXQ0w5NVJVMDNEOVBFVEcAAjczR1ZURFhERUdFMjdNMlhKTVQAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAgMA" xsd:string {name="markers in reference data on Allen Brain Cell Atlas"} property_value: STATO:0000416 "0.0" xsd:float property_value: STATO:0000663 "0.0" xsd:float [Term] id: CLM:5006978 name: S1pr1,Thbs4,Gm29683,Slc39a12 (Yao). xref: https://doi.org/10.1038/s41586-023-06812-z is_a: SO:0001260 ! sequence_collection relationship: BFO:0000051 http://identifiers.org/ncbigene/13609 ! has part S1pr1 (Mmus) relationship: BFO:0000051 http://identifiers.org/ncbigene/21828 ! has part Thbs4 (Mmus) relationship: BFO:0000051 http://identifiers.org/ncbigene/277468 ! has part Slc39a12 (Mmus) relationship: BFO:0000051 http://identifiers.org/ncbigene/624549 ! has part Gm29683 (Mmus) property_value: CLM:0010004 "0.02" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIAAAFDQkdDMFUzMFZWOUpQUjYwVEpVAAIBNTIyOCBBc3Ryby1URSBOTl80AAAEAQECgazGjoGWFSADhGpN%2FYRYGE0ABQQBUzFwcjEAAAFUaGJzNAAAAUdtMjk2ODMAAAFTbGMzOWExMgAABgEBAkNCR0MwVTMwVlY5SlBSNjBUSlUAA34AAAAEAAAIRzRJNEdGSlhKQjlBVFozUFRYMQAJTFZEQkpBVzhCSTVZU1MxUVVCRwAKAAsBbm9uZQACbm9uZQADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAABSzlKTjIzUDI0S1FDR0s5VTc1QQACSFNZWlBaVzE2NjlVODIxQldZUAADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIAAAFDQkdDMFUzMFZWOUpQUjYwVEpVAAIBNTIyOCBBc3Ryby1URSBOTl80AAAEAQAChFC%2FH4OCCX8DhKAah4TEPdkEMk5RVElFN1RBTVA4UFFBSE80UAAFga%2BmSoHprA6BoIFHgJLV6AYABwAABQQBUzFwcjEAAAFUaGJzNAAAAUdtMjk2ODMAAAFTbGMzOWExMgAABgEBAkNCR0MwVTMwVlY5SlBSNjBUSlUAA34AAAAEAAAIVkZPRllQRlFHUktVRFFVWjNGRgAJTFZEQkpBVzhCSTVZU1MxUVVCRwAKAAsBVExPS1dDTDk1UlUwM0Q5UEVURwACNzNHVlREWERFR0UyN00yWEpNVAADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAACAwA%3D" xsd:string {name="markers in reference data on Allen Brain Cell Atlas"} property_value: STATO:0000416 "1.0" xsd:float property_value: STATO:0000663 "0.09259259" xsd:float [Term] id: CLM:5006979 name: S1pr1,Thbs4,Hs3st3a1,Sfrp1 (Yao). xref: https://doi.org/10.1038/s41586-023-06812-z is_a: SO:0001260 ! sequence_collection relationship: BFO:0000051 http://identifiers.org/ncbigene/13609 ! has part S1pr1 (Mmus) relationship: BFO:0000051 http://identifiers.org/ncbigene/15478 ! has part Hs3st3a1 (Mmus) relationship: BFO:0000051 http://identifiers.org/ncbigene/20377 ! has part Sfrp1 (Mmus) relationship: BFO:0000051 http://identifiers.org/ncbigene/21828 ! has part Thbs4 (Mmus) property_value: CLM:0010004 "0.0" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIAAAFDQkdDMFUzMFZWOUpQUjYwVEpVAAIBNTIyOSBBc3Ryby1URSBOTl81AAAEAQECgazGjoGWFSADhGpN%2FYRYGE0ABQQBUzFwcjEAAAFUaGJzNAAAAUhzM3N0M2ExAAABU2ZycDEAAAYBAQJDQkdDMFUzMFZWOUpQUjYwVEpVAAN%2BAAAABAAACEc0STRHRkpYSkI5QVRaM1BUWDEACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAW5vbmUAAm5vbmUAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAUs5Sk4yM1AyNEtRQ0dLOVU3NUEAAkhTWVpQWlcxNjY5VTgyMUJXWVAAAwQBRlMwMERYVjBUOVIxWDlGSjRRRQACAAABUVk1UzhLTU81SExKVUYwUDAwSwACAAABMTVCSzQ3RENJT0YxU0xMVVc5UAACAAABQ0JHQzBVMzBWVjlKUFI2MFRKVQACATUyMjkgQXN0cm8tVEUgTk5fNQAABAEAAoRQvx%2BDggl%2FA4SgGoeExD3ZBDJOUVRJRTdUQU1QOFBRQUhPNFAABYGvpkqB6awOgaCBR4CS1egGAAcAAAUEAVMxcHIxAAABVGhiczQAAAFIczNzdDNhMQAAAVNmcnAxAAAGAQECQ0JHQzBVMzBWVjlKUFI2MFRKVQADfgAAAAQAAAhWRk9GWVBGUUdSS1VEUVVaM0ZGAAlMVkRCSkFXOEJJNVlTUzFRVUJHAAoACwFUTE9LV0NMOTVSVTAzRDlQRVRHAAI3M0dWVERYREVHRTI3TTJYSk1UAAMBBAEAAiMwMDAwMDAAA8gBAAUBAQIjMDAwMDAwAAPIAQAAAAIDAA%3D%3D" xsd:string {name="markers in reference data on Allen Brain Cell Atlas"} property_value: STATO:0000416 "0.0" xsd:float property_value: STATO:0000663 "0.0" xsd:float [Term] id: CLM:5006980 name: S1pr1,Adamts18,Crym (Yao). xref: https://doi.org/10.1038/s41586-023-06812-z is_a: SO:0001260 ! sequence_collection relationship: BFO:0000051 http://identifiers.org/ncbigene/12971 ! has part Crym (Mmus) relationship: BFO:0000051 http://identifiers.org/ncbigene/13609 ! has part S1pr1 (Mmus) relationship: BFO:0000051 http://identifiers.org/ncbigene/208936 ! has part Adamts18 (Mmus) property_value: CLM:0010004 "0.02" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIAAAFDQkdDMFUzMFZWOUpQUjYwVEpVAAIBNTIzMCBBc3Ryby1URSBOTl81AAAEAQECgazGjoGWFSADhGpN%2FYRYGE0ABQMBUzFwcjEAAAFBZGFtdHMxOAAAAUNyeW0AAAYBAQJDQkdDMFUzMFZWOUpQUjYwVEpVAAN%2BAAAABAAACEc0STRHRkpYSkI5QVRaM1BUWDEACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAW5vbmUAAm5vbmUAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAUs5Sk4yM1AyNEtRQ0dLOVU3NUEAAkhTWVpQWlcxNjY5VTgyMUJXWVAAAwQBRlMwMERYVjBUOVIxWDlGSjRRRQACAAABUVk1UzhLTU81SExKVUYwUDAwSwACAAABMTVCSzQ3RENJT0YxU0xMVVc5UAACAAABQ0JHQzBVMzBWVjlKUFI2MFRKVQACATUyMzAgQXN0cm8tVEUgTk5fNQAABAEAAoRQvx%2BDggl%2FA4SgGoeExD3ZBDJOUVRJRTdUQU1QOFBRQUhPNFAABYGvpkqB6awOgaCBR4CS1egGAAcAAAUDAVMxcHIxAAABQWRhbXRzMTgAAAFDcnltAAAGAQECQ0JHQzBVMzBWVjlKUFI2MFRKVQADfgAAAAQAAAhWRk9GWVBGUUdSS1VEUVVaM0ZGAAlMVkRCSkFXOEJJNVlTUzFRVUJHAAoACwFUTE9LV0NMOTVSVTAzRDlQRVRHAAI3M0dWVERYREVHRTI3TTJYSk1UAAMBBAEAAiMwMDAwMDAAA8gBAAUBAQIjMDAwMDAwAAPIAQAAAAIDAA%3D%3D" xsd:string {name="markers in reference data on Allen Brain Cell Atlas"} property_value: STATO:0000416 "1.0" xsd:float property_value: STATO:0000663 "0.09259259" xsd:float [Term] id: CLM:5006981 name: Gja1,Chrdl1,Ano1,Il33 (Yao). xref: https://doi.org/10.1038/s41586-023-06812-z is_a: SO:0001260 ! sequence_collection relationship: BFO:0000051 http://identifiers.org/ncbigene/101772 ! has part Ano1 (Mmus) relationship: BFO:0000051 http://identifiers.org/ncbigene/14609 ! has part Gja1 (Mmus) relationship: BFO:0000051 http://identifiers.org/ncbigene/77125 ! has part Il33 (Mmus) relationship: BFO:0000051 http://identifiers.org/ncbigene/83453 ! has part Chrdl1 (Mmus) property_value: CLM:0010004 "0.02" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIAAAFDQkdDMFUzMFZWOUpQUjYwVEpVAAIBNTIzMSBBc3Ryby1PTEYgTk5fMQAABAEBAoGsxo6BlhUgA4RqTf2EWBhNAAUEAUdqYTEAAAFDaHJkbDEAAAFBbm8xAAABSWwzMwAABgEBAkNCR0MwVTMwVlY5SlBSNjBUSlUAA34AAAAEAAAIRzRJNEdGSlhKQjlBVFozUFRYMQAJTFZEQkpBVzhCSTVZU1MxUVVCRwAKAAsBbm9uZQACbm9uZQADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAABSzlKTjIzUDI0S1FDR0s5VTc1QQACSFNZWlBaVzE2NjlVODIxQldZUAADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIAAAFDQkdDMFUzMFZWOUpQUjYwVEpVAAIBNTIzMSBBc3Ryby1PTEYgTk5fMQAABAEAAoRQvx%2BDggl%2FA4SgGoeExD3ZBDJOUVRJRTdUQU1QOFBRQUhPNFAABYGvpkqB6awOgaCBR4CS1egGAAcAAAUEAUdqYTEAAAFDaHJkbDEAAAFBbm8xAAABSWwzMwAABgEBAkNCR0MwVTMwVlY5SlBSNjBUSlUAA34AAAAEAAAIVkZPRllQRlFHUktVRFFVWjNGRgAJTFZEQkpBVzhCSTVZU1MxUVVCRwAKAAsBVExPS1dDTDk1UlUwM0Q5UEVURwACNzNHVlREWERFR0UyN00yWEpNVAADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAACAwA%3D" xsd:string {name="markers in reference data on Allen Brain Cell Atlas"} property_value: STATO:0000416 "1.0" xsd:float property_value: STATO:0000663 "0.09259259" xsd:float [Term] id: CLM:5006982 name: Aqp4,Prss23,Stk32a (Yao). xref: https://doi.org/10.1038/s41586-023-06812-z is_a: SO:0001260 ! sequence_collection relationship: BFO:0000051 http://identifiers.org/ncbigene/11829 ! has part Aqp4 (Mmus) relationship: BFO:0000051 http://identifiers.org/ncbigene/269019 ! has part Stk32a (Mmus) relationship: BFO:0000051 http://identifiers.org/ncbigene/76453 ! has part Prss23 (Mmus) property_value: CLM:0010004 "0.06" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIAAAFDQkdDMFUzMFZWOUpQUjYwVEpVAAIBNTIzMiBBc3Ryby1PTEYgTk5fMQAABAEBAoGsxo6BlhUgA4RqTf2EWBhNAAUDAUFxcDQAAAFQcnNzMjMAAAFTdGszMmEAAAYBAQJDQkdDMFUzMFZWOUpQUjYwVEpVAAN%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%3D%3D" xsd:string {name="markers in reference data on Allen Brain Cell Atlas"} property_value: STATO:0000416 "1.0" xsd:float property_value: STATO:0000663 "0.24193548" xsd:float [Term] id: CLM:5006983 name: Aqp4,Hs3st3a1,Slc25a34,C4b (Yao). xref: https://doi.org/10.1038/s41586-023-06812-z is_a: SO:0001260 ! sequence_collection relationship: BFO:0000051 http://identifiers.org/ncbigene/11829 ! has part Aqp4 (Mmus) relationship: BFO:0000051 http://identifiers.org/ncbigene/12268 ! has part C4b (Mmus) relationship: BFO:0000051 http://identifiers.org/ncbigene/15478 ! has part Hs3st3a1 (Mmus) relationship: BFO:0000051 http://identifiers.org/ncbigene/384071 ! has part Slc25a34 (Mmus) property_value: CLM:0010004 "0.0" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#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%2FH4OCCX8DhKAah4TEPdkEMk5RVElFN1RBTVA4UFFBSE80UAAFga%2BmSoHprA6BoIFHgJLV6AYABwAABQQBQXFwNAAAAUhzM3N0M2ExAAABU2xjMjVhMzQAAAFDNGIAAAYBAQJDQkdDMFUzMFZWOUpQUjYwVEpVAAN%2BAAAABAAACFZGT0ZZUEZRR1JLVURRVVozRkYACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAVRMT0tXQ0w5NVJVMDNEOVBFVEcAAjczR1ZURFhERUdFMjdNMlhKTVQAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAgMA" xsd:string {name="markers in reference data on Allen Brain Cell Atlas"} property_value: STATO:0000416 "0.0" xsd:float property_value: STATO:0000663 "0.0" xsd:float [Term] id: CLM:5006984 name: S1pr1,Chrdl1,Sfrp1,Atp13a4 (Yao). xref: https://doi.org/10.1038/s41586-023-06812-z is_a: SO:0001260 ! sequence_collection relationship: BFO:0000051 http://identifiers.org/ncbigene/13609 ! has part S1pr1 (Mmus) relationship: BFO:0000051 http://identifiers.org/ncbigene/20377 ! has part Sfrp1 (Mmus) relationship: BFO:0000051 http://identifiers.org/ncbigene/224079 ! has part Atp13a4 (Mmus) relationship: BFO:0000051 http://identifiers.org/ncbigene/83453 ! has part Chrdl1 (Mmus) property_value: CLM:0010004 "0.04" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIAAAFDQkdDMFUzMFZWOUpQUjYwVEpVAAIBNTIzNCBBc3Ryby1PTEYgTk5fMgAABAEBAoGsxo6BlhUgA4RqTf2EWBhNAAUEAVMxcHIxAAABQ2hyZGwxAAABU2ZycDEAAAFBdHAxM2E0AAAGAQECQ0JHQzBVMzBWVjlKUFI2MFRKVQADfgAAAAQAAAhHNEk0R0ZKWEpCOUFUWjNQVFgxAAlMVkRCSkFXOEJJNVlTUzFRVUJHAAoACwFub25lAAJub25lAAMBBAEAAiMwMDAwMDAAA8gBAAUBAQIjMDAwMDAwAAPIAQAAAAFLOUpOMjNQMjRLUUNHSzlVNzVBAAJIU1laUFpXMTY2OVU4MjFCV1lQAAMEAUZTMDBEWFYwVDlSMVg5Rko0UUUAAgAAAVFZNVM4S01PNUhMSlVGMFAwMEsAAgAAATE1Qks0N0RDSU9GMVNMTFVXOVAAAgAAAUNCR0MwVTMwVlY5SlBSNjBUSlUAAgE1MjM0IEFzdHJvLU9MRiBOTl8yAAAEAQAChFC%2FH4OCCX8DhKAah4TEPdkEMk5RVElFN1RBTVA4UFFBSE80UAAFga%2BmSoHprA6BoIFHgJLV6AYABwAABQQBUzFwcjEAAAFDaHJkbDEAAAFTZnJwMQAAAUF0cDEzYTQAAAYBAQJDQkdDMFUzMFZWOUpQUjYwVEpVAAN%2BAAAABAAACFZGT0ZZUEZRR1JLVURRVVozRkYACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAVRMT0tXQ0w5NVJVMDNEOVBFVEcAAjczR1ZURFhERUdFMjdNMlhKTVQAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAgMA" xsd:string {name="markers in reference data on Allen Brain Cell Atlas"} property_value: STATO:0000416 "1.0" xsd:float property_value: STATO:0000663 "0.1724138" xsd:float [Term] id: CLM:5006985 name: C230072F16Rik,Dipk1c,Ecrg4 (Yao). xref: https://doi.org/10.1038/s41586-023-06812-z is_a: SO:0001260 ! sequence_collection relationship: BFO:0000051 http://identifiers.org/ncbigene/240479 ! has part Dipk1c (Mmus) relationship: BFO:0000051 http://identifiers.org/ncbigene/320784 ! has part C230072F16Rik (Mmus) relationship: BFO:0000051 http://identifiers.org/ncbigene/78896 ! has part Ecrg4 (Mmus) property_value: CLM:0010004 "0.1" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#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%2BDggl%2FA4SgGoeExD3ZBDJOUVRJRTdUQU1QOFBRQUhPNFAABYGvpkqB6awOgaCBR4CS1egGAAcAAAUDAUMyMzAwNzJGMTZSaWsAAAFEaXBrMWMAAAFFY3JnNAAABgEBAkNCR0MwVTMwVlY5SlBSNjBUSlUAA34AAAAEAAAIVkZPRllQRlFHUktVRFFVWjNGRgAJTFZEQkpBVzhCSTVZU1MxUVVCRwAKAAsBVExPS1dDTDk1UlUwM0Q5UEVURwACNzNHVlREWERFR0UyN00yWEpNVAADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAACAwA%3D" xsd:string {name="markers in reference data on Allen Brain Cell Atlas"} property_value: STATO:0000416 "1.0" xsd:float property_value: STATO:0000663 "0.35714287" xsd:float [Term] id: CLM:5006986 name: S1pr1,6530411M01Rik,Sfrp1,Aqp4 (Yao). xref: https://doi.org/10.1038/s41586-023-06812-z is_a: SO:0001260 ! 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sequence_collection relationship: BFO:0000051 http://identifiers.org/ncbigene/104798 ! has part Sfta3-ps (Mmus) relationship: BFO:0000051 http://identifiers.org/ncbigene/16840 ! has part Cnmd (Mmus) property_value: CLM:0010004 "0.48" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIAAAFDQkdDMFUzMFZWOUpQUjYwVEpVAAIBNTI0MyBUYW55Y3l0ZSBOTl8xAAAEAQECgazGjoGWFSADhGpN%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%2BAAAABAAACFZGT0ZZUEZRR1JLVURRVVozRkYACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAVRMT0tXQ0w5NVJVMDNEOVBFVEcAAjczR1ZURFhERUdFMjdNMlhKTVQAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAgMA" xsd:string {name="markers in reference data on Allen Brain Cell Atlas"} property_value: STATO:0000416 "1.0" xsd:float property_value: STATO:0000663 "0.82191783" xsd:float [Term] id: CLM:5006994 name: C230072F16Rik,Glp1r (Yao). xref: https://doi.org/10.1038/s41586-023-06812-z is_a: SO:0001260 ! sequence_collection relationship: BFO:0000051 http://identifiers.org/ncbigene/14652 ! has part Glp1r (Mmus) relationship: BFO:0000051 http://identifiers.org/ncbigene/320784 ! has part C230072F16Rik (Mmus) property_value: CLM:0010004 "0.4210526315789473" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIAAAFDQkdDMFUzMFZWOUpQUjYwVEpVAAIBNTI0NCBUYW55Y3l0ZSBOTl8xAAAEAQECgazGjoGWFSADhGpN%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%2BAAAABAAACFZGT0ZZUEZRR1JLVURRVVozRkYACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAVRMT0tXQ0w5NVJVMDNEOVBFVEcAAjczR1ZURFhERUdFMjdNMlhKTVQAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAgMA" xsd:string {name="markers in reference data on Allen Brain Cell Atlas"} property_value: STATO:0000416 "0.84210527" xsd:float property_value: STATO:0000663 "0.7017544" xsd:float [Term] id: CLM:5006995 name: Dynlrb2,Mylk3,Sfta3-ps (Yao). xref: https://doi.org/10.1038/s41586-023-06812-z is_a: SO:0001260 ! sequence_collection relationship: BFO:0000051 http://identifiers.org/ncbigene/104798 ! has part Sfta3-ps (Mmus) relationship: BFO:0000051 http://identifiers.org/ncbigene/213435 ! has part Mylk3 (Mmus) relationship: BFO:0000051 http://identifiers.org/ncbigene/75465 ! has part Dynlrb2 (Mmus) property_value: CLM:0010004 "0.06" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIAAAFDQkdDMFUzMFZWOUpQUjYwVEpVAAIBNTI0NSBUYW55Y3l0ZSBOTl8yAAAEAQECgazGjoGWFSADhGpN%2FYRYGE0ABQMBRHlubHJiMgAAAU15bGszAAABU2Z0YTMtcHMAAAYBAQJDQkdDMFUzMFZWOUpQUjYwVEpVAAN%2BAAAABAAACEc0STRHRkpYSkI5QVRaM1BUWDEACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAW5vbmUAAm5vbmUAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAUs5Sk4yM1AyNEtRQ0dLOVU3NUEAAkhTWVpQWlcxNjY5VTgyMUJXWVAAAwQBRlMwMERYVjBUOVIxWDlGSjRRRQACAAABUVk1UzhLTU81SExKVUYwUDAwSwACAAABMTVCSzQ3RENJT0YxU0xMVVc5UAACAAABQ0JHQzBVMzBWVjlKUFI2MFRKVQACATUyNDUgVGFueWN5dGUgTk5fMgAABAEAAoRQvx%2BDggl%2FA4SgGoeExD3ZBDJOUVRJRTdUQU1QOFBRQUhPNFAABYGvpkqB6awOgaCBR4CS1egGAAcAAAUDAUR5bmxyYjIAAAFNeWxrMwAAAVNmdGEzLXBzAAAGAQECQ0JHQzBVMzBWVjlKUFI2MFRKVQADfgAAAAQAAAhWRk9GWVBGUUdSS1VEUVVaM0ZGAAlMVkRCSkFXOEJJNVlTUzFRVUJHAAoACwFUTE9LV0NMOTVSVTAzRDlQRVRHAAI3M0dWVERYREVHRTI3TTJYSk1UAAMBBAEAAiMwMDAwMDAAA8gBAAUBAQIjMDAwMDAwAAPIAQAAAAIDAA%3D%3D" xsd:string {name="markers in reference data on Allen Brain Cell Atlas"} property_value: STATO:0000416 "1.0" xsd:float property_value: STATO:0000663 "0.24193548" xsd:float [Term] id: CLM:5006996 name: Ccdc170,Nkx2-4,Dock8 (Yao). xref: https://doi.org/10.1038/s41586-023-06812-z is_a: SO:0001260 ! 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sequence_collection relationship: BFO:0000051 http://identifiers.org/ncbigene/114873 ! has part Dscaml1 (Mmus) relationship: BFO:0000051 http://identifiers.org/ncbigene/210530 ! has part P3h2 (Mmus) relationship: BFO:0000051 http://identifiers.org/ncbigene/242253 ! has part Wdr63 (Mmus) relationship: BFO:0000051 http://identifiers.org/ncbigene/69239 ! has part Pdzph1 (Mmus) property_value: CLM:0010004 "0.0" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIAAAFDQkdDMFUzMFZWOUpQUjYwVEpVAAIBNTI0NyBUYW55Y3l0ZSBOTl8yAAAEAQECgazGjoGWFSADhGpN%2FYRYGE0ABQQBUGR6cGgxAAABV2RyNjMAAAFEc2NhbWwxAAABUDNoMgAABgEBAkNCR0MwVTMwVlY5SlBSNjBUSlUAA34AAAAEAAAIRzRJNEdGSlhKQjlBVFozUFRYMQAJTFZEQkpBVzhCSTVZU1MxUVVCRwAKAAsBbm9uZQACbm9uZQADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAABSzlKTjIzUDI0S1FDR0s5VTc1QQACSFNZWlBaVzE2NjlVODIxQldZUAADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIAAAFDQkdDMFUzMFZWOUpQUjYwVEpVAAIBNTI0NyBUYW55Y3l0ZSBOTl8yAAAEAQAChFC%2FH4OCCX8DhKAah4TEPdkEMk5RVElFN1RBTVA4UFFBSE80UAAFga%2BmSoHprA6BoIFHgJLV6AYABwAABQQBUGR6cGgxAAABV2RyNjMAAAFEc2NhbWwxAAABUDNoMgAABgEBAkNCR0MwVTMwVlY5SlBSNjBUSlUAA34AAAAEAAAIVkZPRllQRlFHUktVRFFVWjNGRgAJTFZEQkpBVzhCSTVZU1MxUVVCRwAKAAsBVExPS1dDTDk1UlUwM0Q5UEVURwACNzNHVlREWERFR0UyN00yWEpNVAADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAACAwA%3D" xsd:string {name="markers in reference data on Allen Brain Cell Atlas"} property_value: STATO:0000416 "0.0" xsd:float property_value: STATO:0000663 "0.0" xsd:float [Term] id: CLM:5006998 name: Ccdc146,Tbx3,Otx2 (Yao). xref: https://doi.org/10.1038/s41586-023-06812-z is_a: SO:0001260 ! sequence_collection relationship: BFO:0000051 http://identifiers.org/ncbigene/18424 ! has part Otx2 (Mmus) relationship: BFO:0000051 http://identifiers.org/ncbigene/21386 ! has part Tbx3 (Mmus) relationship: BFO:0000051 http://identifiers.org/ncbigene/75172 ! has part Ccdc146 (Mmus) property_value: CLM:0010004 "0.1388888888888889" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIAAAFDQkdDMFUzMFZWOUpQUjYwVEpVAAIBNTI0OCBUYW55Y3l0ZSBOTl8yAAAEAQECgazGjoGWFSADhGpN%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%2BAAAABAAACFZGT0ZZUEZRR1JLVURRVVozRkYACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAVRMT0tXQ0w5NVJVMDNEOVBFVEcAAjczR1ZURFhERUdFMjdNMlhKTVQAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAgMA" xsd:string {name="markers in reference data on Allen Brain Cell Atlas"} property_value: STATO:0000416 "1.0" xsd:float property_value: STATO:0000663 "0.44642857" xsd:float [Term] id: CLM:5006999 name: Gpr50,Frzb,Foxd2os (Yao). xref: https://doi.org/10.1038/s41586-023-06812-z is_a: SO:0001260 ! sequence_collection relationship: BFO:0000051 http://identifiers.org/ncbigene/100040736 ! has part Foxd2os (Mmus) relationship: BFO:0000051 http://identifiers.org/ncbigene/14765 ! has part Gpr50 (Mmus) relationship: BFO:0000051 http://identifiers.org/ncbigene/20378 ! has part Frzb (Mmus) property_value: CLM:0010004 "0.06" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIAAAFDQkdDMFUzMFZWOUpQUjYwVEpVAAIBNTI0OSBUYW55Y3l0ZSBOTl8yAAAEAQECgazGjoGWFSADhGpN%2FYRYGE0ABQMBR3ByNTAAAAFGcnpiAAABRm94ZDJvcwAABgEBAkNCR0MwVTMwVlY5SlBSNjBUSlUAA34AAAAEAAAIRzRJNEdGSlhKQjlBVFozUFRYMQAJTFZEQkpBVzhCSTVZU1MxUVVCRwAKAAsBbm9uZQACbm9uZQADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAABSzlKTjIzUDI0S1FDR0s5VTc1QQACSFNZWlBaVzE2NjlVODIxQldZUAADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIAAAFDQkdDMFUzMFZWOUpQUjYwVEpVAAIBNTI0OSBUYW55Y3l0ZSBOTl8yAAAEAQAChFC%2FH4OCCX8DhKAah4TEPdkEMk5RVElFN1RBTVA4UFFBSE80UAAFga%2BmSoHprA6BoIFHgJLV6AYABwAABQMBR3ByNTAAAAFGcnpiAAABRm94ZDJvcwAABgEBAkNCR0MwVTMwVlY5SlBSNjBUSlUAA34AAAAEAAAIVkZPRllQRlFHUktVRFFVWjNGRgAJTFZEQkpBVzhCSTVZU1MxUVVCRwAKAAsBVExPS1dDTDk1UlUwM0Q5UEVURwACNzNHVlREWERFR0UyN00yWEpNVAADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAACAwA%3D" xsd:string {name="markers in reference data on Allen Brain Cell Atlas"} property_value: STATO:0000416 "1.0" xsd:float property_value: STATO:0000663 "0.24193548" xsd:float [Term] id: CLM:5007000 name: Fndc3c1,Ecrg4 (Yao). xref: https://doi.org/10.1038/s41586-023-06812-z is_a: SO:0001260 ! sequence_collection relationship: BFO:0000051 http://identifiers.org/ncbigene/333564 ! has part Fndc3c1 (Mmus) relationship: BFO:0000051 http://identifiers.org/ncbigene/78896 ! has part Ecrg4 (Mmus) property_value: CLM:0010004 "0.4634146341463415" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIAAAFDQkdDMFUzMFZWOUpQUjYwVEpVAAIBNTI1MCBUYW55Y3l0ZSBOTl8zAAAEAQECgazGjoGWFSADhGpN%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%2BAAAABAAACFZGT0ZZUEZRR1JLVURRVVozRkYACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAVRMT0tXQ0w5NVJVMDNEOVBFVEcAAjczR1ZURFhERUdFMjdNMlhKTVQAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAgMA" xsd:string {name="markers in reference data on Allen Brain Cell Atlas"} property_value: STATO:0000416 "0.8636364" xsd:float property_value: STATO:0000663 "0.7364341" xsd:float [Term] id: CLM:5007013 name: Sspo,Wfdc2 (Yao). xref: https://doi.org/10.1038/s41586-023-06812-z is_a: SO:0001260 ! sequence_collection relationship: BFO:0000051 http://identifiers.org/ncbigene/243369 ! has part Sspo (Mmus) relationship: BFO:0000051 http://identifiers.org/ncbigene/67701 ! has part Wfdc2 (Mmus) property_value: CLM:0010004 "0.58" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIBMzI0IEh5cGVuZHltYWwgTk4AAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIAAAFDQkdDMFUzMFZWOUpQUjYwVEpVAAIAAAQBAQKBrMaOgZYVIAOEak39hFgYTQAFAgFTc3BvAAABV2ZkYzIAAAYBAQJRWTVTOEtNTzVITEpVRjBQMDBLAAN%2BAAAABAAACEc0STRHRkpYSkI5QVRaM1BUWDEACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAW5vbmUAAm5vbmUAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAUs5Sk4yM1AyNEtRQ0dLOVU3NUEAAkhTWVpQWlcxNjY5VTgyMUJXWVAAAwQBRlMwMERYVjBUOVIxWDlGSjRRRQACAAABUVk1UzhLTU81SExKVUYwUDAwSwACATMyNCBIeXBlbmR5bWFsIE5OAAABMTVCSzQ3RENJT0YxU0xMVVc5UAACAAABQ0JHQzBVMzBWVjlKUFI2MFRKVQACAAAEAQAChFC%2FH4OCCX8DhKAah4TEPdkEMk5RVElFN1RBTVA4UFFBSE80UAAFga%2BmSoHprA6BoIFHgJLV6AYABwAABQIBU3NwbwAAAVdmZGMyAAAGAQECUVk1UzhLTU81SExKVUYwUDAwSwADfgAAAAQAAAhWRk9GWVBGUUdSS1VEUVVaM0ZGAAlMVkRCSkFXOEJJNVlTUzFRVUJHAAoACwFUTE9LV0NMOTVSVTAzRDlQRVRHAAI3M0dWVERYREVHRTI3TTJYSk1UAAMBBAEAAiMwMDAwMDAAA8gBAAUBAQIjMDAwMDAwAAPIAQAAAAIDAA%3D%3D" xsd:string {name="markers in reference data on Allen Brain Cell Atlas"} property_value: STATO:0000416 "1.0" xsd:float property_value: STATO:0000663 "0.87349397" xsd:float [Term] id: CLM:5007014 name: 2900040C04Rik,Tbc1d1 (Yao). xref: https://doi.org/10.1038/s41586-023-06812-z is_a: SO:0001260 ! sequence_collection relationship: BFO:0000051 http://identifiers.org/ncbigene/57915 ! has part Tbc1d1 (Mmus) relationship: BFO:0000051 http://identifiers.org/ncbigene/72893 ! has part 2900040C04Rik (Mmus) property_value: CLM:0010004 "0.3" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#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%2BDggl%2FA4SgGoeExD3ZBDJOUVRJRTdUQU1QOFBRQUhPNFAABYGvpkqB6awOgaCBR4CS1egGAAcAAAUCATI5MDAwNDBDMDRSaWsAAAFUYmMxZDEAAAYBAQJDQkdDMFUzMFZWOUpQUjYwVEpVAAN%2BAAAABAAACFZGT0ZZUEZRR1JLVURRVVozRkYACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAVRMT0tXQ0w5NVJVMDNEOVBFVEcAAjczR1ZURFhERUdFMjdNMlhKTVQAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAgMA" xsd:string {name="markers in reference data on Allen Brain Cell Atlas"} property_value: STATO:0000416 "1.0" xsd:float property_value: STATO:0000663 "0.6818182" xsd:float [Term] id: CLM:5007015 name: 2900040C04Rik,Slc17a8 (Yao). xref: https://doi.org/10.1038/s41586-023-06812-z is_a: SO:0001260 ! sequence_collection relationship: BFO:0000051 http://identifiers.org/ncbigene/216227 ! has part Slc17a8 (Mmus) relationship: BFO:0000051 http://identifiers.org/ncbigene/72893 ! has part 2900040C04Rik (Mmus) property_value: CLM:0010004 "0.52" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#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%3D" xsd:string {name="markers in reference data on Allen Brain Cell Atlas"} property_value: STATO:0000416 "0.962963" xsd:float property_value: STATO:0000663 "0.8227848" xsd:float [Term] id: CLM:5007016 name: Pdgfra,Pclaf,Mki67,Foxg1 (Yao). xref: https://doi.org/10.1038/s41586-023-06812-z is_a: SO:0001260 ! sequence_collection relationship: BFO:0000051 http://identifiers.org/ncbigene/15228 ! has part Foxg1 (Mmus) relationship: BFO:0000051 http://identifiers.org/ncbigene/17345 ! has part Mki67 (Mmus) relationship: BFO:0000051 http://identifiers.org/ncbigene/18595 ! has part Pdgfra (Mmus) relationship: BFO:0000051 http://identifiers.org/ncbigene/68026 ! has part Pclaf (Mmus) property_value: CLM:0010004 "0.14" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#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%2BDggl%2FA4SgGoeExD3ZBDJOUVRJRTdUQU1QOFBRQUhPNFAABYGvpkqB6awOgaCBR4CS1egGAAcAAAUEAVBkZ2ZyYQAAAVBjbGFmAAABTWtpNjcAAAFGb3hnMQAABgEBAkNCR0MwVTMwVlY5SlBSNjBUSlUAA34AAAAEAAAIVkZPRllQRlFHUktVRFFVWjNGRgAJTFZEQkpBVzhCSTVZU1MxUVVCRwAKAAsBVExPS1dDTDk1UlUwM0Q5UEVURwACNzNHVlREWERFR0UyN00yWEpNVAADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAACAwA%3D" xsd:string {name="markers in reference data on Allen Brain Cell Atlas"} property_value: STATO:0000416 "0.7777778" xsd:float property_value: STATO:0000663 "0.40697673" xsd:float [Term] id: CLM:5007017 name: Pdgfra,Pclaf,Irx2 (Yao). xref: https://doi.org/10.1038/s41586-023-06812-z is_a: SO:0001260 ! sequence_collection relationship: BFO:0000051 http://identifiers.org/ncbigene/16372 ! has part Irx2 (Mmus) relationship: BFO:0000051 http://identifiers.org/ncbigene/18595 ! has part Pdgfra (Mmus) relationship: BFO:0000051 http://identifiers.org/ncbigene/68026 ! has part Pclaf (Mmus) property_value: CLM:0010004 "0.4" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#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%2BDggl%2FA4SgGoeExD3ZBDJOUVRJRTdUQU1QOFBRQUhPNFAABYGvpkqB6awOgaCBR4CS1egGAAcAAAUDAVBkZ2ZyYQAAAVBjbGFmAAABSXJ4MgAABgEBAkNCR0MwVTMwVlY5SlBSNjBUSlUAA34AAAAEAAAIVkZPRllQRlFHUktVRFFVWjNGRgAJTFZEQkpBVzhCSTVZU1MxUVVCRwAKAAsBVExPS1dDTDk1UlUwM0Q5UEVURwACNzNHVlREWERFR0UyN00yWEpNVAADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAACAwA%3D" xsd:string {name="markers in reference data on Allen Brain Cell Atlas"} property_value: STATO:0000416 "0.90909094" xsd:float property_value: STATO:0000663 "0.7246377" xsd:float [Term] id: CLM:5007018 name: Pdgfra,Olig1,Mms22l,Top2a (Yao). xref: https://doi.org/10.1038/s41586-023-06812-z is_a: SO:0001260 ! sequence_collection relationship: BFO:0000051 http://identifiers.org/ncbigene/18595 ! has part Pdgfra (Mmus) relationship: BFO:0000051 http://identifiers.org/ncbigene/212377 ! has part Mms22l (Mmus) relationship: BFO:0000051 http://identifiers.org/ncbigene/21973 ! has part Top2a (Mmus) relationship: BFO:0000051 http://identifiers.org/ncbigene/50914 ! has part Olig1 (Mmus) property_value: CLM:0010004 "0.12" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIAAAFDQkdDMFUzMFZWOUpQUjYwVEpVAAIBNTI2OCBPUEMgTk5fMQAABAEBAoGsxo6BlhUgA4RqTf2EWBhNAAUEAVBkZ2ZyYQAAAU9saWcxAAABTW1zMjJsAAABVG9wMmEAAAYBAQJDQkdDMFUzMFZWOUpQUjYwVEpVAAN%2BAAAABAAACEc0STRHRkpYSkI5QVRaM1BUWDEACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAW5vbmUAAm5vbmUAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAUs5Sk4yM1AyNEtRQ0dLOVU3NUEAAkhTWVpQWlcxNjY5VTgyMUJXWVAAAwQBRlMwMERYVjBUOVIxWDlGSjRRRQACAAABUVk1UzhLTU81SExKVUYwUDAwSwACAAABMTVCSzQ3RENJT0YxU0xMVVc5UAACAAABQ0JHQzBVMzBWVjlKUFI2MFRKVQACATUyNjggT1BDIE5OXzEAAAQBAAKEUL8fg4IJfwOEoBqHhMQ92QQyTlFUSUU3VEFNUDhQUUFITzRQAAWBr6ZKgemsDoGggUeAktXoBgAHAAAFBAFQZGdmcmEAAAFPbGlnMQAAAU1tczIybAAAAVRvcDJhAAAGAQECQ0JHQzBVMzBWVjlKUFI2MFRKVQADfgAAAAQAAAhWRk9GWVBGUUdSS1VEUVVaM0ZGAAlMVkRCSkFXOEJJNVlTUzFRVUJHAAoACwFUTE9LV0NMOTVSVTAzRDlQRVRHAAI3M0dWVERYREVHRTI3TTJYSk1UAAMBBAEAAiMwMDAwMDAAA8gBAAUBAQIjMDAwMDAwAAPIAQAAAAIDAA%3D%3D" xsd:string {name="markers in reference data on Allen Brain Cell Atlas"} property_value: STATO:0000416 "0.21428572" xsd:float property_value: STATO:0000663 "0.18518518" xsd:float [Term] id: CLM:5007019 name: Pdgfra,Olig1,Col27a1 (Yao). xref: https://doi.org/10.1038/s41586-023-06812-z is_a: SO:0001260 ! sequence_collection relationship: BFO:0000051 http://identifiers.org/ncbigene/18595 ! has part Pdgfra (Mmus) relationship: BFO:0000051 http://identifiers.org/ncbigene/373864 ! has part Col27a1 (Mmus) relationship: BFO:0000051 http://identifiers.org/ncbigene/50914 ! has part Olig1 (Mmus) property_value: CLM:0010004 "0.26" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#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%2BDggl%2FA4SgGoeExD3ZBDJOUVRJRTdUQU1QOFBRQUhPNFAABYGvpkqB6awOgaCBR4CS1egGAAcAAAUDAVBkZ2ZyYQAAAU9saWcxAAABQ29sMjdhMQAABgEBAkNCR0MwVTMwVlY5SlBSNjBUSlUAA34AAAAEAAAIVkZPRllQRlFHUktVRFFVWjNGRgAJTFZEQkpBVzhCSTVZU1MxUVVCRwAKAAsBVExPS1dDTDk1UlUwM0Q5UEVURwACNzNHVlREWERFR0UyN00yWEpNVAADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAACAwA%3D" xsd:string {name="markers in reference data on Allen Brain Cell Atlas"} property_value: STATO:0000416 "0.43333334" xsd:float property_value: STATO:0000663 "0.38235295" xsd:float [Term] id: CLM:5007020 name: Pdgfra,Olig1,Rmi2,Col27a1 (Yao). xref: https://doi.org/10.1038/s41586-023-06812-z is_a: SO:0001260 ! sequence_collection relationship: BFO:0000051 http://identifiers.org/ncbigene/18595 ! has part Pdgfra (Mmus) relationship: BFO:0000051 http://identifiers.org/ncbigene/223970 ! has part Rmi2 (Mmus) relationship: BFO:0000051 http://identifiers.org/ncbigene/373864 ! has part Col27a1 (Mmus) relationship: BFO:0000051 http://identifiers.org/ncbigene/50914 ! has part Olig1 (Mmus) property_value: CLM:0010004 "0.0" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIAAAFDQkdDMFUzMFZWOUpQUjYwVEpVAAIBNTI3MCBPUEMgTk5fMQAABAEBAoGsxo6BlhUgA4RqTf2EWBhNAAUEAVBkZ2ZyYQAAAU9saWcxAAABUm1pMgAAAUNvbDI3YTEAAAYBAQJDQkdDMFUzMFZWOUpQUjYwVEpVAAN%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%3D%3D" xsd:string {name="markers in reference data on Allen Brain Cell Atlas"} property_value: STATO:0000416 "0.0" xsd:float property_value: STATO:0000663 "0.0" xsd:float [Term] id: CLM:5007021 name: Pdgfra,Cenpf,Cenpa (Yao). xref: https://doi.org/10.1038/s41586-023-06812-z is_a: SO:0001260 ! sequence_collection relationship: BFO:0000051 http://identifiers.org/ncbigene/108000 ! has part Cenpf (Mmus) relationship: BFO:0000051 http://identifiers.org/ncbigene/12615 ! has part Cenpa (Mmus) relationship: BFO:0000051 http://identifiers.org/ncbigene/18595 ! has part Pdgfra (Mmus) property_value: CLM:0010004 "0.26" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIAAAFDQkdDMFUzMFZWOUpQUjYwVEpVAAIBNTI3MSBPUEMgTk5fMgAABAEBAoGsxo6BlhUgA4RqTf2EWBhNAAUDAVBkZ2ZyYQAAAUNlbnBmAAABQ2VucGEAAAYBAQJDQkdDMFUzMFZWOUpQUjYwVEpVAAN%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%3D%3D" xsd:string {name="markers in reference data on Allen Brain Cell Atlas"} property_value: STATO:0000416 "1.0" xsd:float property_value: STATO:0000663 "0.6372549" xsd:float [Term] id: CLM:5007022 name: Gpr17,Bmp4,Zfp36l1 (Yao). xref: https://doi.org/10.1038/s41586-023-06812-z is_a: SO:0001260 ! sequence_collection relationship: BFO:0000051 http://identifiers.org/ncbigene/12159 ! has part Bmp4 (Mmus) relationship: BFO:0000051 http://identifiers.org/ncbigene/12192 ! has part Zfp36l1 (Mmus) relationship: BFO:0000051 http://identifiers.org/ncbigene/574402 ! has part Gpr17 (Mmus) property_value: CLM:0010004 "0.14" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIAAAFDQkdDMFUzMFZWOUpQUjYwVEpVAAIBNTI3MiBDT1AgTk5fMQAABAEBAoGsxo6BlhUgA4RqTf2EWBhNAAUDAUdwcjE3AAABQm1wNAAAAVpmcDM2bDEAAAYBAQJDQkdDMFUzMFZWOUpQUjYwVEpVAAN%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%3D%3D" xsd:string {name="markers in reference data on Allen Brain Cell Atlas"} property_value: STATO:0000416 "0.7" xsd:float property_value: STATO:0000663 "0.3888889" xsd:float [Term] id: CLM:5007023 name: Gpr17,Gp1bb,Pdzd2,Plekhg1 (Yao). xref: https://doi.org/10.1038/s41586-023-06812-z is_a: SO:0001260 ! sequence_collection relationship: BFO:0000051 http://identifiers.org/ncbigene/14724 ! has part Gp1bb (Mmus) relationship: BFO:0000051 http://identifiers.org/ncbigene/213783 ! has part Plekhg1 (Mmus) relationship: BFO:0000051 http://identifiers.org/ncbigene/574402 ! has part Gpr17 (Mmus) relationship: BFO:0000051 http://identifiers.org/ncbigene/68070 ! has part Pdzd2 (Mmus) property_value: CLM:0010004 "0.02" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIAAAFDQkdDMFUzMFZWOUpQUjYwVEpVAAIBNTI3MyBDT1AgTk5fMQAABAEBAoGsxo6BlhUgA4RqTf2EWBhNAAUEAUdwcjE3AAABR3AxYmIAAAFQZHpkMgAAAVBsZWtoZzEAAAYBAQJDQkdDMFUzMFZWOUpQUjYwVEpVAAN%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%3D%3D" xsd:string {name="markers in reference data on Allen Brain Cell Atlas"} property_value: STATO:0000416 "0.33333334" xsd:float property_value: STATO:0000663 "0.08064516" xsd:float [Term] id: CLM:5007024 name: Gpr17,Bgn,Gstp1,C1ql1 (Yao). xref: https://doi.org/10.1038/s41586-023-06812-z is_a: SO:0001260 ! sequence_collection relationship: BFO:0000051 http://identifiers.org/ncbigene/12111 ! has part Bgn (Mmus) relationship: BFO:0000051 http://identifiers.org/ncbigene/14870 ! has part Gstp1 (Mmus) relationship: BFO:0000051 http://identifiers.org/ncbigene/23829 ! has part C1ql1 (Mmus) relationship: BFO:0000051 http://identifiers.org/ncbigene/574402 ! has part Gpr17 (Mmus) property_value: CLM:0010004 "0.0" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#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%2BDggl%2FA4SgGoeExD3ZBDJOUVRJRTdUQU1QOFBRQUhPNFAABYGvpkqB6awOgaCBR4CS1egGAAcAAAUEAUdwcjE3AAABQmduAAABR3N0cDEAAAFDMXFsMQAABgEBAkNCR0MwVTMwVlY5SlBSNjBUSlUAA34AAAAEAAAIVkZPRllQRlFHUktVRFFVWjNGRgAJTFZEQkpBVzhCSTVZU1MxUVVCRwAKAAsBVExPS1dDTDk1UlUwM0Q5UEVURwACNzNHVlREWERFR0UyN00yWEpNVAADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAACAwA%3D" xsd:string {name="markers in reference data on Allen Brain Cell Atlas"} property_value: STATO:0000416 "0.0" xsd:float property_value: STATO:0000663 "0.0" xsd:float [Term] id: CLM:5007025 name: 9630013A20Rik,Bmp4,Mob3b (Yao). xref: https://doi.org/10.1038/s41586-023-06812-z is_a: SO:0001260 ! sequence_collection relationship: BFO:0000051 http://identifiers.org/ncbigene/12159 ! has part Bmp4 (Mmus) relationship: BFO:0000051 http://identifiers.org/ncbigene/214944 ! has part Mob3b (Mmus) relationship: BFO:0000051 http://identifiers.org/ncbigene/319903 ! has part 9630013A20Rik (Mmus) property_value: CLM:0010004 "0.32" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIAAAFDQkdDMFUzMFZWOUpQUjYwVEpVAAIBNTI3NSBDT1AgTk5fMQAABAEBAoGsxo6BlhUgA4RqTf2EWBhNAAUDATk2MzAwMTNBMjBSaWsAAAFCbXA0AAABTW9iM2IAAAYBAQJDQkdDMFUzMFZWOUpQUjYwVEpVAAN%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%3D%3D" xsd:string {name="markers in reference data on Allen Brain Cell Atlas"} property_value: STATO:0000416 "0.36363637" xsd:float property_value: STATO:0000663 "0.3539823" xsd:float [Term] id: CLM:5007026 name: 9630013A20Rik,Rab32,Opalin (Yao). xref: https://doi.org/10.1038/s41586-023-06812-z is_a: SO:0001260 ! sequence_collection relationship: BFO:0000051 http://identifiers.org/ncbigene/226115 ! has part Opalin (Mmus) relationship: BFO:0000051 http://identifiers.org/ncbigene/319903 ! has part 9630013A20Rik (Mmus) relationship: BFO:0000051 http://identifiers.org/ncbigene/67844 ! has part Rab32 (Mmus) property_value: CLM:0010004 "0.12" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#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%2BDggl%2FA4SgGoeExD3ZBDJOUVRJRTdUQU1QOFBRQUhPNFAABYGvpkqB6awOgaCBR4CS1egGAAcAAAUDATk2MzAwMTNBMjBSaWsAAAFSYWIzMgAAAU9wYWxpbgAABgEBAkNCR0MwVTMwVlY5SlBSNjBUSlUAA34AAAAEAAAIVkZPRllQRlFHUktVRFFVWjNGRgAJTFZEQkpBVzhCSTVZU1MxUVVCRwAKAAsBVExPS1dDTDk1UlUwM0Q5UEVURwACNzNHVlREWERFR0UyN00yWEpNVAADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAACAwA%3D" xsd:string {name="markers in reference data on Allen Brain Cell Atlas"} property_value: STATO:0000416 "0.54545456" xsd:float property_value: STATO:0000663 "0.31914893" xsd:float [Term] id: CLM:5007027 name: 9630013A20Rik,Bmp4,Cck,Ptger1 (Yao). xref: https://doi.org/10.1038/s41586-023-06812-z is_a: SO:0001260 ! sequence_collection relationship: BFO:0000051 http://identifiers.org/ncbigene/12159 ! has part Bmp4 (Mmus) relationship: BFO:0000051 http://identifiers.org/ncbigene/12424 ! has part Cck (Mmus) relationship: BFO:0000051 http://identifiers.org/ncbigene/19216 ! has part Ptger1 (Mmus) relationship: BFO:0000051 http://identifiers.org/ncbigene/319903 ! has part 9630013A20Rik (Mmus) property_value: CLM:0010004 "0.06" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#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%2FH4OCCX8DhKAah4TEPdkEMk5RVElFN1RBTVA4UFFBSE80UAAFga%2BmSoHprA6BoIFHgJLV6AYABwAABQQBOTYzMDAxM0EyMFJpawAAAUJtcDQAAAFDY2sAAAFQdGdlcjEAAAYBAQJDQkdDMFUzMFZWOUpQUjYwVEpVAAN%2BAAAABAAACFZGT0ZZUEZRR1JLVURRVVozRkYACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAVRMT0tXQ0w5NVJVMDNEOVBFVEcAAjczR1ZURFhERUdFMjdNMlhKTVQAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAgMA" xsd:string {name="markers in reference data on Allen Brain Cell Atlas"} property_value: STATO:0000416 "0.75" xsd:float property_value: STATO:0000663 "0.22727273" xsd:float [Term] id: CLM:5007028 name: 9630013A20Rik,Grin2b (Yao). xref: https://doi.org/10.1038/s41586-023-06812-z is_a: SO:0001260 ! sequence_collection relationship: BFO:0000051 http://identifiers.org/ncbigene/14812 ! has part Grin2b (Mmus) relationship: BFO:0000051 http://identifiers.org/ncbigene/319903 ! has part 9630013A20Rik (Mmus) property_value: CLM:0010004 "0.3333333333333333" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#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%2BDggl%2FA4SgGoeExD3ZBDJOUVRJRTdUQU1QOFBRQUhPNFAABYGvpkqB6awOgaCBR4CS1egGAAcAAAUCATk2MzAwMTNBMjBSaWsAAAFHcmluMmIAAAYBAQJDQkdDMFUzMFZWOUpQUjYwVEpVAAN%2BAAAABAAACFZGT0ZZUEZRR1JLVURRVVozRkYACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAVRMT0tXQ0w5NVJVMDNEOVBFVEcAAjczR1ZURFhERUdFMjdNMlhKTVQAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAgMA" xsd:string {name="markers in reference data on Allen Brain Cell Atlas"} property_value: STATO:0000416 "0.15625" xsd:float property_value: STATO:0000663 "0.17482518" xsd:float [Term] id: CLM:5007029 name: 9630013A20Rik,Dbx2,Rassf10 (Yao). xref: https://doi.org/10.1038/s41586-023-06812-z is_a: SO:0001260 ! sequence_collection relationship: BFO:0000051 http://identifiers.org/ncbigene/223843 ! has part Dbx2 (Mmus) relationship: BFO:0000051 http://identifiers.org/ncbigene/319903 ! has part 9630013A20Rik (Mmus) relationship: BFO:0000051 http://identifiers.org/ncbigene/78748 ! has part Rassf10 (Mmus) property_value: CLM:0010004 "0.22" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIAAAFDQkdDMFUzMFZWOUpQUjYwVEpVAAIBNTI3OSBORk9MIE5OXzIAAAQBAQKBrMaOgZYVIAOEak39hFgYTQAFAwE5NjMwMDEzQTIwUmlrAAABRGJ4MgAAAVJhc3NmMTAAAAYBAQJDQkdDMFUzMFZWOUpQUjYwVEpVAAN%2BAAAABAAACEc0STRHRkpYSkI5QVRaM1BUWDEACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAW5vbmUAAm5vbmUAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAUs5Sk4yM1AyNEtRQ0dLOVU3NUEAAkhTWVpQWlcxNjY5VTgyMUJXWVAAAwQBRlMwMERYVjBUOVIxWDlGSjRRRQACAAABUVk1UzhLTU81SExKVUYwUDAwSwACAAABMTVCSzQ3RENJT0YxU0xMVVc5UAACAAABQ0JHQzBVMzBWVjlKUFI2MFRKVQACATUyNzkgTkZPTCBOTl8yAAAEAQAChFC%2FH4OCCX8DhKAah4TEPdkEMk5RVElFN1RBTVA4UFFBSE80UAAFga%2BmSoHprA6BoIFHgJLV6AYABwAABQMBOTYzMDAxM0EyMFJpawAAAURieDIAAAFSYXNzZjEwAAAGAQECQ0JHQzBVMzBWVjlKUFI2MFRKVQADfgAAAAQAAAhWRk9GWVBGUUdSS1VEUVVaM0ZGAAlMVkRCSkFXOEJJNVlTUzFRVUJHAAoACwFUTE9LV0NMOTVSVTAzRDlQRVRHAAI3M0dWVERYREVHRTI3TTJYSk1UAAMBBAEAAiMwMDAwMDAAA8gBAAUBAQIjMDAwMDAwAAPIAQAAAAIDAA%3D%3D" xsd:string {name="markers in reference data on Allen Brain Cell Atlas"} property_value: STATO:0000416 "0.84615386" xsd:float property_value: STATO:0000663 "0.5392157" xsd:float [Term] id: CLM:5007030 name: 9630013A20Rik,Rgs16,Rhbdl2 (Yao). xref: https://doi.org/10.1038/s41586-023-06812-z is_a: SO:0001260 ! sequence_collection relationship: BFO:0000051 http://identifiers.org/ncbigene/19734 ! has part Rgs16 (Mmus) relationship: BFO:0000051 http://identifiers.org/ncbigene/230726 ! has part Rhbdl2 (Mmus) relationship: BFO:0000051 http://identifiers.org/ncbigene/319903 ! has part 9630013A20Rik (Mmus) property_value: CLM:0010004 "0.1" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIAAAFDQkdDMFUzMFZWOUpQUjYwVEpVAAIBNTI4MCBORk9MIE5OXzIAAAQBAQKBrMaOgZYVIAOEak39hFgYTQAFAwE5NjMwMDEzQTIwUmlrAAABUmdzMTYAAAFSaGJkbDIAAAYBAQJDQkdDMFUzMFZWOUpQUjYwVEpVAAN%2BAAAABAAACEc0STRHRkpYSkI5QVRaM1BUWDEACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAW5vbmUAAm5vbmUAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAUs5Sk4yM1AyNEtRQ0dLOVU3NUEAAkhTWVpQWlcxNjY5VTgyMUJXWVAAAwQBRlMwMERYVjBUOVIxWDlGSjRRRQACAAABUVk1UzhLTU81SExKVUYwUDAwSwACAAABMTVCSzQ3RENJT0YxU0xMVVc5UAACAAABQ0JHQzBVMzBWVjlKUFI2MFRKVQACATUyODAgTkZPTCBOTl8yAAAEAQAChFC%2FH4OCCX8DhKAah4TEPdkEMk5RVElFN1RBTVA4UFFBSE80UAAFga%2BmSoHprA6BoIFHgJLV6AYABwAABQMBOTYzMDAxM0EyMFJpawAAAVJnczE2AAABUmhiZGwyAAAGAQECQ0JHQzBVMzBWVjlKUFI2MFRKVQADfgAAAAQAAAhWRk9GWVBGUUdSS1VEUVVaM0ZGAAlMVkRCSkFXOEJJNVlTUzFRVUJHAAoACwFUTE9LV0NMOTVSVTAzRDlQRVRHAAI3M0dWVERYREVHRTI3TTJYSk1UAAMBBAEAAiMwMDAwMDAAA8gBAAUBAQIjMDAwMDAwAAPIAQAAAAIDAA%3D%3D" xsd:string {name="markers in reference data on Allen Brain Cell Atlas"} property_value: STATO:0000416 "0.71428573" xsd:float property_value: STATO:0000663 "0.32051283" xsd:float [Term] id: CLM:5007031 name: 9630013A20Rik,Piezo2,Ptprb (Yao). xref: https://doi.org/10.1038/s41586-023-06812-z is_a: SO:0001260 ! sequence_collection relationship: BFO:0000051 http://identifiers.org/ncbigene/19263 ! has part Ptprb (Mmus) relationship: BFO:0000051 http://identifiers.org/ncbigene/319903 ! has part 9630013A20Rik (Mmus) relationship: BFO:0000051 http://identifiers.org/ncbigene/667742 ! has part Piezo2 (Mmus) property_value: CLM:0010004 "0.1" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIAAAFDQkdDMFUzMFZWOUpQUjYwVEpVAAIBNTI4MSBORk9MIE5OXzIAAAQBAQKBrMaOgZYVIAOEak39hFgYTQAFAwE5NjMwMDEzQTIwUmlrAAABUGllem8yAAABUHRwcmIAAAYBAQJDQkdDMFUzMFZWOUpQUjYwVEpVAAN%2BAAAABAAACEc0STRHRkpYSkI5QVRaM1BUWDEACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAW5vbmUAAm5vbmUAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAUs5Sk4yM1AyNEtRQ0dLOVU3NUEAAkhTWVpQWlcxNjY5VTgyMUJXWVAAAwQBRlMwMERYVjBUOVIxWDlGSjRRRQACAAABUVk1UzhLTU81SExKVUYwUDAwSwACAAABMTVCSzQ3RENJT0YxU0xMVVc5UAACAAABQ0JHQzBVMzBWVjlKUFI2MFRKVQACATUyODEgTkZPTCBOTl8yAAAEAQAChFC%2FH4OCCX8DhKAah4TEPdkEMk5RVElFN1RBTVA4UFFBSE80UAAFga%2BmSoHprA6BoIFHgJLV6AYABwAABQMBOTYzMDAxM0EyMFJpawAAAVBpZXpvMgAAAVB0cHJiAAAGAQECQ0JHQzBVMzBWVjlKUFI2MFRKVQADfgAAAAQAAAhWRk9GWVBGUUdSS1VEUVVaM0ZGAAlMVkRCSkFXOEJJNVlTUzFRVUJHAAoACwFUTE9LV0NMOTVSVTAzRDlQRVRHAAI3M0dWVERYREVHRTI3TTJYSk1UAAMBBAEAAiMwMDAwMDAAA8gBAAUBAQIjMDAwMDAwAAPIAQAAAAIDAA%3D%3D" xsd:string {name="markers in reference data on Allen Brain Cell Atlas"} property_value: STATO:0000416 "1.0" xsd:float property_value: STATO:0000663 "0.35714287" xsd:float [Term] id: CLM:5007032 name: Opalin,Cxcl12,Efhd1 (Yao). xref: https://doi.org/10.1038/s41586-023-06812-z is_a: SO:0001260 ! sequence_collection relationship: BFO:0000051 http://identifiers.org/ncbigene/20315 ! has part Cxcl12 (Mmus) relationship: BFO:0000051 http://identifiers.org/ncbigene/226115 ! has part Opalin (Mmus) relationship: BFO:0000051 http://identifiers.org/ncbigene/98363 ! has part Efhd1 (Mmus) property_value: CLM:0010004 "0.12" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIAAAFDQkdDMFUzMFZWOUpQUjYwVEpVAAIBNTI4MiBNRk9MIE5OXzMAAAQBAQKBrMaOgZYVIAOEak39hFgYTQAFAwFPcGFsaW4AAAFDeGNsMTIAAAFFZmhkMQAABgEBAkNCR0MwVTMwVlY5SlBSNjBUSlUAA34AAAAEAAAIRzRJNEdGSlhKQjlBVFozUFRYMQAJTFZEQkpBVzhCSTVZU1MxUVVCRwAKAAsBbm9uZQACbm9uZQADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAABSzlKTjIzUDI0S1FDR0s5VTc1QQACSFNZWlBaVzE2NjlVODIxQldZUAADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIAAAFDQkdDMFUzMFZWOUpQUjYwVEpVAAIBNTI4MiBNRk9MIE5OXzMAAAQBAAKEUL8fg4IJfwOEoBqHhMQ92QQyTlFUSUU3VEFNUDhQUUFITzRQAAWBr6ZKgemsDoGggUeAktXoBgAHAAAFAwFPcGFsaW4AAAFDeGNsMTIAAAFFZmhkMQAABgEBAkNCR0MwVTMwVlY5SlBSNjBUSlUAA34AAAAEAAAIVkZPRllQRlFHUktVRFFVWjNGRgAJTFZEQkpBVzhCSTVZU1MxUVVCRwAKAAsBVExPS1dDTDk1UlUwM0Q5UEVURwACNzNHVlREWERFR0UyN00yWEpNVAADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAACAwA%3D" xsd:string {name="markers in reference data on Allen Brain Cell Atlas"} property_value: STATO:0000416 "1.0" xsd:float property_value: STATO:0000663 "0.4054054" xsd:float [Term] id: CLM:5007033 name: 9630013A20Rik,Ppp1r14a,Mroh3 (Yao). xref: https://doi.org/10.1038/s41586-023-06812-z is_a: SO:0001260 ! sequence_collection relationship: BFO:0000051 http://identifiers.org/ncbigene/319903 ! has part 9630013A20Rik (Mmus) relationship: BFO:0000051 http://identifiers.org/ncbigene/68458 ! has part Ppp1r14a (Mmus) relationship: BFO:0000051 http://identifiers.org/ncbigene/76422 ! has part Mroh3 (Mmus) property_value: CLM:0010004 "0.1" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIAAAFDQkdDMFUzMFZWOUpQUjYwVEpVAAIBNTI4MyBNRk9MIE5OXzMAAAQBAQKBrMaOgZYVIAOEak39hFgYTQAFAwE5NjMwMDEzQTIwUmlrAAABUHBwMXIxNGEAAAFNcm9oMwAABgEBAkNCR0MwVTMwVlY5SlBSNjBUSlUAA34AAAAEAAAIRzRJNEdGSlhKQjlBVFozUFRYMQAJTFZEQkpBVzhCSTVZU1MxUVVCRwAKAAsBbm9uZQACbm9uZQADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAABSzlKTjIzUDI0S1FDR0s5VTc1QQACSFNZWlBaVzE2NjlVODIxQldZUAADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIAAAFDQkdDMFUzMFZWOUpQUjYwVEpVAAIBNTI4MyBNRk9MIE5OXzMAAAQBAAKEUL8fg4IJfwOEoBqHhMQ92QQyTlFUSUU3VEFNUDhQUUFITzRQAAWBr6ZKgemsDoGggUeAktXoBgAHAAAFAwE5NjMwMDEzQTIwUmlrAAABUHBwMXIxNGEAAAFNcm9oMwAABgEBAkNCR0MwVTMwVlY5SlBSNjBUSlUAA34AAAAEAAAIVkZPRllQRlFHUktVRFFVWjNGRgAJTFZEQkpBVzhCSTVZU1MxUVVCRwAKAAsBVExPS1dDTDk1UlUwM0Q5UEVURwACNzNHVlREWERFR0UyN00yWEpNVAADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAACAwA%3D" xsd:string {name="markers in reference data on Allen Brain Cell Atlas"} property_value: STATO:0000416 "1.0" xsd:float property_value: STATO:0000663 "0.35714287" xsd:float [Term] id: CLM:5007034 name: Prr5l,Hapln2,Enpp6,Grm7 (Yao). xref: https://doi.org/10.1038/s41586-023-06812-z is_a: SO:0001260 ! sequence_collection relationship: BFO:0000051 http://identifiers.org/ncbigene/108073 ! has part Grm7 (Mmus) relationship: BFO:0000051 http://identifiers.org/ncbigene/320981 ! has part Enpp6 (Mmus) relationship: BFO:0000051 http://identifiers.org/ncbigene/72446 ! has part Prr5l (Mmus) relationship: BFO:0000051 http://identifiers.org/ncbigene/73940 ! has part Hapln2 (Mmus) property_value: CLM:0010004 "0.26" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#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%2FH4OCCX8DhKAah4TEPdkEMk5RVElFN1RBTVA4UFFBSE80UAAFga%2BmSoHprA6BoIFHgJLV6AYABwAABQQBUHJyNWwAAAFIYXBsbjIAAAFFbnBwNgAAAUdybTcAAAYBAQJDQkdDMFUzMFZWOUpQUjYwVEpVAAN%2BAAAABAAACFZGT0ZZUEZRR1JLVURRVVozRkYACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAVRMT0tXQ0w5NVJVMDNEOVBFVEcAAjczR1ZURFhERUdFMjdNMlhKTVQAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAgMA" xsd:string {name="markers in reference data on Allen Brain Cell Atlas"} property_value: STATO:0000416 "0.61904764" xsd:float property_value: STATO:0000663 "0.48507464" xsd:float [Term] id: CLM:5007035 name: Cldn11,A230001M10Rik,Spock3,Rhoj (Yao). xref: https://doi.org/10.1038/s41586-023-06812-z is_a: SO:0001260 ! sequence_collection relationship: BFO:0000051 http://identifiers.org/ncbigene/18417 ! has part Cldn11 (Mmus) relationship: BFO:0000051 http://identifiers.org/ncbigene/319951 ! has part A230001M10Rik (Mmus) relationship: BFO:0000051 http://identifiers.org/ncbigene/72902 ! has part Spock3 (Mmus) relationship: BFO:0000051 http://identifiers.org/ncbigene/80837 ! has part Rhoj (Mmus) property_value: CLM:0010004 "0.06" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#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%2FH4OCCX8DhKAah4TEPdkEMk5RVElFN1RBTVA4UFFBSE80UAAFga%2BmSoHprA6BoIFHgJLV6AYABwAABQQBQ2xkbjExAAABQTIzMDAwMU0xMFJpawAAAVNwb2NrMwAAAVJob2oAAAYBAQJDQkdDMFUzMFZWOUpQUjYwVEpVAAN%2BAAAABAAACFZGT0ZZUEZRR1JLVURRVVozRkYACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAVRMT0tXQ0w5NVJVMDNEOVBFVEcAAjczR1ZURFhERUdFMjdNMlhKTVQAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAgMA" xsd:string {name="markers in reference data on Allen Brain Cell Atlas"} property_value: STATO:0000416 "1.0" xsd:float property_value: STATO:0000663 "0.24193548" xsd:float [Term] id: CLM:5007036 name: Apod,Klk6,Dlc1 (Yao). xref: https://doi.org/10.1038/s41586-023-06812-z is_a: SO:0001260 ! sequence_collection relationship: BFO:0000051 http://identifiers.org/ncbigene/11815 ! has part Apod (Mmus) relationship: BFO:0000051 http://identifiers.org/ncbigene/19144 ! has part Klk6 (Mmus) relationship: BFO:0000051 http://identifiers.org/ncbigene/50768 ! has part Dlc1 (Mmus) property_value: CLM:0010004 "0.46" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#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%2BDggl%2FA4SgGoeExD3ZBDJOUVRJRTdUQU1QOFBRQUhPNFAABYGvpkqB6awOgaCBR4CS1egGAAcAAAUDAUFwb2QAAAFLbGs2AAABRGxjMQAABgEBAkNCR0MwVTMwVlY5SlBSNjBUSlUAA34AAAAEAAAIVkZPRllQRlFHUktVRFFVWjNGRgAJTFZEQkpBVzhCSTVZU1MxUVVCRwAKAAsBVExPS1dDTDk1UlUwM0Q5UEVURwACNzNHVlREWERFR0UyN00yWEpNVAADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAACAwA%3D" xsd:string {name="markers in reference data on Allen Brain Cell Atlas"} property_value: STATO:0000416 "0.9583333" xsd:float property_value: STATO:0000663 "0.7876712" xsd:float [Term] id: CLM:5007037 name: Opalin,Grm3,Gm5087 (Yao). xref: https://doi.org/10.1038/s41586-023-06812-z is_a: SO:0001260 ! sequence_collection relationship: BFO:0000051 http://identifiers.org/ncbigene/108069 ! has part Grm3 (Mmus) relationship: BFO:0000051 http://identifiers.org/ncbigene/226115 ! has part Opalin (Mmus) relationship: BFO:0000051 http://identifiers.org/ncbigene/328354 ! has part Gm5087 (Mmus) property_value: CLM:0010004 "0.12" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIAAAFDQkdDMFUzMFZWOUpQUjYwVEpVAAIBNTI4NyBNT0wgTk5fNAAABAEBAoGsxo6BlhUgA4RqTf2EWBhNAAUDAU9wYWxpbgAAAUdybTMAAAFHbTUwODcAAAYBAQJDQkdDMFUzMFZWOUpQUjYwVEpVAAN%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%3D%3D" xsd:string {name="markers in reference data on Allen Brain Cell Atlas"} property_value: STATO:0000416 "0.6" xsd:float property_value: STATO:0000663 "0.33333334" xsd:float [Term] id: CLM:5007038 name: Mog,Anln,Gm32633 (Yao). xref: https://doi.org/10.1038/s41586-023-06812-z is_a: SO:0001260 ! sequence_collection relationship: BFO:0000051 http://identifiers.org/ncbigene/102635243 ! has part Gm32633 (Mmus) relationship: BFO:0000051 http://identifiers.org/ncbigene/17441 ! has part Mog (Mmus) relationship: BFO:0000051 http://identifiers.org/ncbigene/68743 ! has part Anln (Mmus) property_value: CLM:0010004 "0.2" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#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%2FH4OCCX8DhKAah4TEPdkEMk5RVElFN1RBTVA4UFFBSE80UAAFga%2BmSoHprA6BoIFHgJLV6AYABwAABQMBTW9nAAABQW5sbgAAAUdtMzI2MzMAAAYBAQJDQkdDMFUzMFZWOUpQUjYwVEpVAAN%2BAAAABAAACFZGT0ZZUEZRR1JLVURRVVozRkYACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAVRMT0tXQ0w5NVJVMDNEOVBFVEcAAjczR1ZURFhERUdFMjdNMlhKTVQAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAgMA" xsd:string {name="markers in reference data on Allen Brain Cell Atlas"} property_value: STATO:0000416 "0.45454547" xsd:float property_value: STATO:0000663 "0.36231884" xsd:float [Term] id: CLM:5007039 name: Cldn5,Adamts12 (Yao). xref: https://doi.org/10.1038/s41586-023-06812-z is_a: SO:0001260 ! sequence_collection relationship: BFO:0000051 http://identifiers.org/ncbigene/12741 ! has part Cldn5 (Mmus) relationship: BFO:0000051 http://identifiers.org/ncbigene/239337 ! has part Adamts12 (Mmus) property_value: CLM:0010004 "0.36" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIAAAFDQkdDMFUzMFZWOUpQUjYwVEpVAAIBNTI4OSBPRUMgTk5fMQAABAEBAoGsxo6BlhUgA4RqTf2EWBhNAAUCAUNsZG41AAABQWRhbXRzMTIAAAYBAQJDQkdDMFUzMFZWOUpQUjYwVEpVAAN%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%3D%3D" xsd:string {name="markers in reference data on Allen Brain Cell Atlas"} property_value: STATO:0000416 "0.94736844" xsd:float property_value: STATO:0000663 "0.71428573" xsd:float [Term] id: CLM:5007040 name: Apod,Aqp1,Cldn5 (Yao). xref: https://doi.org/10.1038/s41586-023-06812-z is_a: SO:0001260 ! sequence_collection relationship: BFO:0000051 http://identifiers.org/ncbigene/11815 ! has part Apod (Mmus) relationship: BFO:0000051 http://identifiers.org/ncbigene/11826 ! has part Aqp1 (Mmus) relationship: BFO:0000051 http://identifiers.org/ncbigene/12741 ! has part Cldn5 (Mmus) property_value: CLM:0010004 "0.2" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIAAAFDQkdDMFUzMFZWOUpQUjYwVEpVAAIBNTI5MCBPRUMgTk5fMQAABAEBAoGsxo6BlhUgA4RqTf2EWBhNAAUDAUFwb2QAAAFBcXAxAAABQ2xkbjUAAAYBAQJDQkdDMFUzMFZWOUpQUjYwVEpVAAN%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%3D%3D" xsd:string {name="markers in reference data on Allen Brain Cell Atlas"} property_value: STATO:0000416 "0.7692308" xsd:float property_value: STATO:0000663 "0.49019608" xsd:float [Term] id: CLM:5007041 name: Apod,Mybpc1,Syk (Yao). xref: https://doi.org/10.1038/s41586-023-06812-z is_a: SO:0001260 ! sequence_collection relationship: BFO:0000051 http://identifiers.org/ncbigene/109272 ! has part Mybpc1 (Mmus) relationship: BFO:0000051 http://identifiers.org/ncbigene/11815 ! has part Apod (Mmus) relationship: BFO:0000051 http://identifiers.org/ncbigene/20963 ! has part Syk (Mmus) property_value: CLM:0010004 "0.16" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIAAAFDQkdDMFUzMFZWOUpQUjYwVEpVAAIBNTI5MSBPRUMgTk5fMQAABAEBAoGsxo6BlhUgA4RqTf2EWBhNAAUDAUFwb2QAAAFNeWJwYzEAAAFTeWsAAAYBAQJDQkdDMFUzMFZWOUpQUjYwVEpVAAN%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%3D%3D" xsd:string {name="markers in reference data on Allen Brain Cell Atlas"} property_value: STATO:0000416 "0.8" xsd:float property_value: STATO:0000663 "0.44444445" xsd:float [Term] id: CLM:5007042 name: Apod,Mybpc1,Rasgef1c (Yao). xref: https://doi.org/10.1038/s41586-023-06812-z is_a: SO:0001260 ! sequence_collection relationship: BFO:0000051 http://identifiers.org/ncbigene/109272 ! has part Mybpc1 (Mmus) relationship: BFO:0000051 http://identifiers.org/ncbigene/11815 ! has part Apod (Mmus) relationship: BFO:0000051 http://identifiers.org/ncbigene/74563 ! has part Rasgef1c (Mmus) property_value: CLM:0010004 "0.02" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#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%2BDggl%2FA4SgGoeExD3ZBDJOUVRJRTdUQU1QOFBRQUhPNFAABYGvpkqB6awOgaCBR4CS1egGAAcAAAUDAUFwb2QAAAFNeWJwYzEAAAFSYXNnZWYxYwAABgEBAkNCR0MwVTMwVlY5SlBSNjBUSlUAA34AAAAEAAAIVkZPRllQRlFHUktVRFFVWjNGRgAJTFZEQkpBVzhCSTVZU1MxUVVCRwAKAAsBVExPS1dDTDk1UlUwM0Q5UEVURwACNzNHVlREWERFR0UyN00yWEpNVAADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAACAwA%3D" xsd:string {name="markers in reference data on Allen Brain Cell Atlas"} property_value: STATO:0000416 "1.0" xsd:float property_value: STATO:0000663 "0.09259259" xsd:float [Term] id: CLM:5007043 name: Slc47a1,Pde11a (Yao). xref: https://doi.org/10.1038/s41586-023-06812-z is_a: SO:0001260 ! sequence_collection relationship: BFO:0000051 http://identifiers.org/ncbigene/241489 ! has part Pde11a (Mmus) relationship: BFO:0000051 http://identifiers.org/ncbigene/67473 ! has part Slc47a1 (Mmus) property_value: CLM:0010004 "0.28" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIAAAFDQkdDMFUzMFZWOUpQUjYwVEpVAAIBNTI5MyBBQkMgTk5fMQAABAEBAoGsxo6BlhUgA4RqTf2EWBhNAAUCAVNsYzQ3YTEAAAFQZGUxMWEAAAYBAQJDQkdDMFUzMFZWOUpQUjYwVEpVAAN%2BAAAABAAACEc0STRHRkpYSkI5QVRaM1BUWDEACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAW5vbmUAAm5vbmUAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAUs5Sk4yM1AyNEtRQ0dLOVU3NUEAAkhTWVpQWlcxNjY5VTgyMUJXWVAAAwQBRlMwMERYVjBUOVIxWDlGSjRRRQACAAABUVk1UzhLTU81SExKVUYwUDAwSwACAAABMTVCSzQ3RENJT0YxU0xMVVc5UAACAAABQ0JHQzBVMzBWVjlKUFI2MFRKVQACATUyOTMgQUJDIE5OXzEAAAQBAAKEUL8fg4IJfwOEoBqHhMQ92QQyTlFUSUU3VEFNUDhQUUFITzRQAAWBr6ZKgemsDoGggUeAktXoBgAHAAAFAgFTbGM0N2ExAAABUGRlMTFhAAAGAQECQ0JHQzBVMzBWVjlKUFI2MFRKVQADfgAAAAQAAAhWRk9GWVBGUUdSS1VEUVVaM0ZGAAlMVkRCSkFXOEJJNVlTUzFRVUJHAAoACwFUTE9LV0NMOTVSVTAzRDlQRVRHAAI3M0dWVERYREVHRTI3TTJYSk1UAAMBBAEAAiMwMDAwMDAAA8gBAAUBAQIjMDAwMDAwAAPIAQAAAAIDAA%3D%3D" xsd:string {name="markers in reference data on Allen Brain Cell Atlas"} property_value: STATO:0000416 "1.0" xsd:float property_value: STATO:0000663 "0.6603774" xsd:float [Term] id: CLM:5007044 name: Slc47a1,Dapl1 (Yao). xref: https://doi.org/10.1038/s41586-023-06812-z is_a: SO:0001260 ! sequence_collection relationship: BFO:0000051 http://identifiers.org/ncbigene/67473 ! has part Slc47a1 (Mmus) relationship: BFO:0000051 http://identifiers.org/ncbigene/76747 ! has part Dapl1 (Mmus) property_value: CLM:0010004 "0.54" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#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%2BDggl%2FA4SgGoeExD3ZBDJOUVRJRTdUQU1QOFBRQUhPNFAABYGvpkqB6awOgaCBR4CS1egGAAcAAAUCAVNsYzQ3YTEAAAFEYXBsMQAABgEBAkNCR0MwVTMwVlY5SlBSNjBUSlUAA34AAAAEAAAIVkZPRllQRlFHUktVRFFVWjNGRgAJTFZEQkpBVzhCSTVZU1MxUVVCRwAKAAsBVExPS1dDTDk1UlUwM0Q5UEVURwACNzNHVlREWERFR0UyN00yWEpNVAADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAACAwA%3D" xsd:string {name="markers in reference data on Allen Brain Cell Atlas"} property_value: STATO:0000416 "0.7297297" xsd:float property_value: STATO:0000663 "0.6818182" xsd:float [Term] id: CLM:5007045 name: Prg4,Cubn (Yao). xref: https://doi.org/10.1038/s41586-023-06812-z is_a: SO:0001260 ! sequence_collection relationship: BFO:0000051 http://identifiers.org/ncbigene/65969 ! has part Cubn (Mmus) relationship: BFO:0000051 http://identifiers.org/ncbigene/96875 ! has part Prg4 (Mmus) property_value: CLM:0010004 "0.56" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#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%2FH4OCCX8DhKAah4TEPdkEMk5RVElFN1RBTVA4UFFBSE80UAAFga%2BmSoHprA6BoIFHgJLV6AYABwAABQIBUHJnNAAAAUN1Ym4AAAYBAQJDQkdDMFUzMFZWOUpQUjYwVEpVAAN%2BAAAABAAACFZGT0ZZUEZRR1JLVURRVVozRkYACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAVRMT0tXQ0w5NVJVMDNEOVBFVEcAAjczR1ZURFhERUdFMjdNMlhKTVQAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAgMA" xsd:string {name="markers in reference data on Allen Brain Cell Atlas"} property_value: STATO:0000416 "1.0" xsd:float property_value: STATO:0000663 "0.86419755" xsd:float [Term] id: CLM:5007062 name: C1qa,Tmem119 (Yao). xref: https://doi.org/10.1038/s41586-023-06812-z is_a: SO:0001260 ! sequence_collection relationship: BFO:0000051 http://identifiers.org/ncbigene/12259 ! has part C1qa (Mmus) relationship: BFO:0000051 http://identifiers.org/ncbigene/231633 ! has part Tmem119 (Mmus) property_value: CLM:0010004 "0.92" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#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%2FH4OCCX8DhKAah4TEPdkEMk5RVElFN1RBTVA4UFFBSE80UAAFga%2BmSoHprA6BoIFHgJLV6AYABwAABQIBQzFxYQAAAVRtZW0xMTkAAAYBAQJRWTVTOEtNTzVITEpVRjBQMDBLAAN%2BAAAABAAACFZGT0ZZUEZRR1JLVURRVVozRkYACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAVRMT0tXQ0w5NVJVMDNEOVBFVEcAAjczR1ZURFhERUdFMjdNMlhKTVQAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAgMA" xsd:string {name="markers in reference data on Allen Brain Cell Atlas"} property_value: STATO:0000416 "1.0" xsd:float property_value: STATO:0000663 "0.982906" xsd:float [Term] id: CLM:5007063 name: Mrc1,Pf4 (Yao). xref: https://doi.org/10.1038/s41586-023-06812-z is_a: SO:0001260 ! sequence_collection relationship: BFO:0000051 http://identifiers.org/ncbigene/17533 ! has part Mrc1 (Mmus) relationship: BFO:0000051 http://identifiers.org/ncbigene/56744 ! has part Pf4 (Mmus) property_value: CLM:0010004 "0.96" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIAAAFDQkdDMFUzMFZWOUpQUjYwVEpVAAIBNTMxMyBCQU0gTk5fMQAABAEBAoGsxo6BlhUgA4RqTf2EWBhNAAUCAU1yYzEAAAFQZjQAAAYBAQJDQkdDMFUzMFZWOUpQUjYwVEpVAAN%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%3D%3D" xsd:string {name="markers in reference data on Allen Brain Cell Atlas"} property_value: STATO:0000416 "0.49484536" xsd:float property_value: STATO:0000663 "0.5479452" xsd:float [Term] id: CLM:5007064 name: Mrc1,Pf4,Fos (Yao). xref: https://doi.org/10.1038/s41586-023-06812-z is_a: SO:0001260 ! 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sequence_collection relationship: BFO:0000051 http://identifiers.org/ncbigene/14714 ! has part Gnrh1 (Mmus) property_value: CLM:0010004 "0.96" xsd:string property_value: IAO:0000064 "NSforest" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#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%2FH4OCCX8DhKAah4TEPdkEMk5RVElFN1RBTVA4UFFBSE80UAAFga%2BmSoHprA6BoIFHgJLV6AYABwAABQEBR25yaDEAAAYBAQJGUzAwRFhWMFQ5UjFYOUZKNFFFAAN%2BAAAABAAACFZGT0ZZUEZRR1JLVURRVVozRkYACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAVRMT0tXQ0w5NVJVMDNEOVBFVEcAAjczR1ZURFhERUdFMjdNMlhKTVQAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAgMA" xsd:string {name="markers in reference data on Allen Brain Cell Atlas"} property_value: STATO:0000416 "1.0" xsd:float property_value: STATO:0000663 "0.9917355" xsd:float [Term] id: CLM:5007645 name: Gnb3, Pde6g, Gm44196 (NSforest). xref: https://doi.org/10.1101/2020.09.23.308932 is_a: SO:0001260 ! 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sequence_collection relationship: BFO:0000051 http://identifiers.org/ncbigene/11540 ! has part Adora2a (Mmus) relationship: BFO:0000051 http://identifiers.org/ncbigene/19049 ! has part Ppp1r1b (Mmus) property_value: CLM:0010004 "0.53728949478749" xsd:string property_value: IAO:0000064 "NSforest" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIBMDYyIFNUUiBEMiBHYWJhAAABMTVCSzQ3RENJT0YxU0xMVVc5UAACAAABQ0JHQzBVMzBWVjlKUFI2MFRKVQACAAAEAQECgazGjoGWFSADhGpN%2FYRYGE0ABQIBQWRvcmEyYQAAAVBwcDFyMWIAAAYBAQJRWTVTOEtNTzVITEpVRjBQMDBLAAN%2BAAAABAAACEc0STRHRkpYSkI5QVRaM1BUWDEACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAW5vbmUAAm5vbmUAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAUs5Sk4yM1AyNEtRQ0dLOVU3NUEAAkhTWVpQWlcxNjY5VTgyMUJXWVAAAwQBRlMwMERYVjBUOVIxWDlGSjRRRQACAAABUVk1UzhLTU81SExKVUYwUDAwSwACATA2MiBTVFIgRDIgR2FiYQAAATE1Qks0N0RDSU9GMVNMTFVXOVAAAgAAAUNCR0MwVTMwVlY5SlBSNjBUSlUAAgAABAEAAoRQvx%2BDggl%2FA4SgGoeExD3ZBDJOUVRJRTdUQU1QOFBRQUhPNFAABYGvpkqB6awOgaCBR4CS1egGAAcAAAUCAUFkb3JhMmEAAAFQcHAxcjFiAAAGAQECUVk1UzhLTU81SExKVUYwUDAwSwADfgAAAAQAAAhWRk9GWVBGUUdSS1VEUVVaM0ZGAAlMVkRCSkFXOEJJNVlTUzFRVUJHAAoACwFUTE9LV0NMOTVSVTAzRDlQRVRHAAI3M0dWVERYREVHRTI3TTJYSk1UAAMBBAEAAiMwMDAwMDAAA8gBAAUBAQIjMDAwMDAwAAPIAQAAAAIDAA%3D%3D" xsd:string {name="markers in reference data on Allen Brain Cell Atlas"} property_value: STATO:0000416 "0.9626437" xsd:float property_value: STATO:0000663 "0.8310593" xsd:float [Term] id: CLM:5007802 name: Gnrh1 2 (NSforest). xref: https://doi.org/10.1101/2020.09.23.308932 is_a: SO:0001260 ! sequence_collection relationship: BFO:0000051 http://identifiers.org/ncbigene/14714 ! has part Gnrh1 (Mmus) property_value: CLM:0010004 "0.96" xsd:string property_value: IAO:0000064 "NSforest" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#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%2BDggl%2FA4SgGoeExD3ZBDJOUVRJRTdUQU1QOFBRQUhPNFAABYGvpkqB6awOgaCBR4CS1egGAAcAAAUBAUducmgxIDIAAAYBAQJRWTVTOEtNTzVITEpVRjBQMDBLAAN%2BAAAABAAACFZGT0ZZUEZRR1JLVURRVVozRkYACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAVRMT0tXQ0w5NVJVMDNEOVBFVEcAAjczR1ZURFhERUdFMjdNMlhKTVQAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAgMA" xsd:string {name="markers in reference data on Allen Brain Cell Atlas"} property_value: STATO:0000416 "1.0" xsd:float property_value: STATO:0000663 "0.9917355" xsd:float [Term] id: CLM:5007922 name: Pde6g, Gnb3, Gm44196 (NSforest). xref: https://doi.org/10.1101/2020.09.23.308932 is_a: SO:0001260 ! sequence_collection relationship: BFO:0000051 http://identifiers.org/ncbigene/14695 ! has part Gnb3 (Mmus) relationship: BFO:0000051 http://identifiers.org/ncbigene/18588 ! has part Pde6g (Mmus) relationship: BFO:0000051 http://identifiers.org/ncbigene/77808 ! has part Gm44196 (Mmus) property_value: CLM:0010004 "0.9" xsd:string property_value: IAO:0000064 "NSforest" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIBMjYyIFBpbmVhbCBDcnggR2x1dAAAATE1Qks0N0RDSU9GMVNMTFVXOVAAAgAAAUNCR0MwVTMwVlY5SlBSNjBUSlUAAgAABAEBAoGsxo6BlhUgA4RqTf2EWBhNAAUDAVBkZTZnAAABR25iMwAAAUdtNDQxOTYAAAYBAQJRWTVTOEtNTzVITEpVRjBQMDBLAAN%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%3D%3D" xsd:string {name="markers in reference data on Allen Brain Cell Atlas"} property_value: STATO:0000416 "1.0" xsd:float property_value: STATO:0000663 "0.9782609" xsd:float [Term] id: CLM:5007968 name: Fam107b, Pvalb, Bhlhe22 (NSforest). xref: https://doi.org/10.1101/2020.09.23.308932 is_a: SO:0001260 ! sequence_collection relationship: BFO:0000051 http://identifiers.org/ncbigene/19293 ! has part Pvalb (Mmus) relationship: BFO:0000051 http://identifiers.org/ncbigene/59058 ! has part Bhlhe22 (Mmus) relationship: BFO:0000051 http://identifiers.org/ncbigene/66540 ! has part Fam107b (Mmus) property_value: CLM:0010004 "0.1962025316455696" xsd:string property_value: IAO:0000064 "NSforest" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIBMzA4IERDTyBJbDIyIEdseS1HYWJhAAABMTVCSzQ3RENJT0YxU0xMVVc5UAACAAABQ0JHQzBVMzBWVjlKUFI2MFRKVQACAAAEAQECgazGjoGWFSADhGpN%2FYRYGE0ABQMBRmFtMTA3YgAAAVB2YWxiAAABQmhsaGUyMgAABgEBAlFZNVM4S01PNUhMSlVGMFAwMEsAA34AAAAEAAAIRzRJNEdGSlhKQjlBVFozUFRYMQAJTFZEQkpBVzhCSTVZU1MxUVVCRwAKAAsBbm9uZQACbm9uZQADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAABSzlKTjIzUDI0S1FDR0s5VTc1QQACSFNZWlBaVzE2NjlVODIxQldZUAADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIBMzA4IERDTyBJbDIyIEdseS1HYWJhAAABMTVCSzQ3RENJT0YxU0xMVVc5UAACAAABQ0JHQzBVMzBWVjlKUFI2MFRKVQACAAAEAQAChFC%2FH4OCCX8DhKAah4TEPdkEMk5RVElFN1RBTVA4UFFBSE80UAAFga%2BmSoHprA6BoIFHgJLV6AYABwAABQMBRmFtMTA3YgAAAVB2YWxiAAABQmhsaGUyMgAABgEBAlFZNVM4S01PNUhMSlVGMFAwMEsAA34AAAAEAAAIVkZPRllQRlFHUktVRFFVWjNGRgAJTFZEQkpBVzhCSTVZU1MxUVVCRwAKAAsBVExPS1dDTDk1UlUwM0Q5UEVURwACNzNHVlREWERFR0UyN00yWEpNVAADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAACAwA%3D" xsd:string {name="markers in reference data on Allen Brain Cell Atlas"} property_value: STATO:0000416 "0.93939394" xsd:float property_value: STATO:0000663 "0.5344828" xsd:float [Term] id: CLM:5007969 name: Inhba, Tfap2b (NSforest). xref: https://doi.org/10.1101/2020.09.23.308932 is_a: SO:0001260 ! sequence_collection relationship: BFO:0000051 http://identifiers.org/ncbigene/16323 ! has part Inhba (Mmus) relationship: BFO:0000051 http://identifiers.org/ncbigene/21419 ! has part Tfap2b (Mmus) property_value: CLM:0010004 "0.2517647058823529" xsd:string property_value: IAO:0000064 "NSforest" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#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%2FH4OCCX8DhKAah4TEPdkEMk5RVElFN1RBTVA4UFFBSE80UAAFga%2BmSoHprA6BoIFHgJLV6AYABwAABQIBSW5oYmEAAAFUZmFwMmIAAAYBAQJRWTVTOEtNTzVITEpVRjBQMDBLAAN%2BAAAABAAACFZGT0ZZUEZRR1JLVURRVVozRkYACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAVRMT0tXQ0w5NVJVMDNEOVBFVEcAAjczR1ZURFhERUdFMjdNMlhKTVQAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAgMA" xsd:string {name="markers in reference data on Allen Brain Cell Atlas"} property_value: STATO:0000416 "0.8167939" xsd:float property_value: STATO:0000663 "0.56375134" xsd:float [Term] id: CLM:5007970 name: Scrg1, Grm2 (NSforest). xref: https://doi.org/10.1101/2020.09.23.308932 is_a: SO:0001260 ! 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sequence_collection relationship: BFO:0000051 http://identifiers.org/ncbigene/104174 ! has part Gldc (Mmus) relationship: BFO:0000051 http://identifiers.org/ncbigene/19293 ! has part Pvalb (Mmus) property_value: CLM:0010004 "0.295" xsd:string property_value: IAO:0000064 "NSforest" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIBMzExIENCWCBNTEkgTWVnZjExIEdhYmEAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIAAAFDQkdDMFUzMFZWOUpQUjYwVEpVAAIAAAQBAQKBrMaOgZYVIAOEak39hFgYTQAFAgFHbGRjAAABUHZhbGIAAAYBAQJRWTVTOEtNTzVITEpVRjBQMDBLAAN%2BAAAABAAACEc0STRHRkpYSkI5QVRaM1BUWDEACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAW5vbmUAAm5vbmUAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAUs5Sk4yM1AyNEtRQ0dLOVU3NUEAAkhTWVpQWlcxNjY5VTgyMUJXWVAAAwQBRlMwMERYVjBUOVIxWDlGSjRRRQACAAABUVk1UzhLTU81SExKVUYwUDAwSwACATMxMSBDQlggTUxJIE1lZ2YxMSBHYWJhAAABMTVCSzQ3RENJT0YxU0xMVVc5UAACAAABQ0JHQzBVMzBWVjlKUFI2MFRKVQACAAAEAQAChFC%2FH4OCCX8DhKAah4TEPdkEMk5RVElFN1RBTVA4UFFBSE80UAAFga%2BmSoHprA6BoIFHgJLV6AYABwAABQIBR2xkYwAAAVB2YWxiAAAGAQECUVk1UzhLTU81SExKVUYwUDAwSwADfgAAAAQAAAhWRk9GWVBGUUdSS1VEUVVaM0ZGAAlMVkRCSkFXOEJJNVlTUzFRVUJHAAoACwFUTE9LV0NMOTVSVTAzRDlQRVRHAAI3M0dWVERYREVHRTI3TTJYSk1UAAMBBAEAAiMwMDAwMDAAA8gBAAUBAQIjMDAwMDAwAAPIAQAAAAIDAA%3D%3D" xsd:string {name="markers in reference data on Allen Brain Cell Atlas"} property_value: STATO:0000416 "0.9672131" xsd:float property_value: STATO:0000663 "0.6644144" xsd:float [Term] id: CLM:5007972 name: Gm45459, Afap1l2 (NSforest). xref: https://doi.org/10.1101/2020.09.23.308932 is_a: SO:0001260 ! sequence_collection relationship: BFO:0000051 http://identifiers.org/ensembl/ENSMUSG00000109994 ! has part Gm45459 (Mmus) relationship: BFO:0000051 http://identifiers.org/ncbigene/226250 ! has part Afap1l2 (Mmus) property_value: CLM:0010004 "0.26" xsd:string property_value: IAO:0000064 "NSforest" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#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%2FH4OCCX8DhKAah4TEPdkEMk5RVElFN1RBTVA4UFFBSE80UAAFga%2BmSoHprA6BoIFHgJLV6AYABwAABQIBR200NTQ1OQAAAUFmYXAxbDIAAAYBAQJRWTVTOEtNTzVITEpVRjBQMDBLAAN%2BAAAABAAACFZGT0ZZUEZRR1JLVURRVVozRkYACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAVRMT0tXQ0w5NVJVMDNEOVBFVEcAAjczR1ZURFhERUdFMjdNMlhKTVQAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAgMA" xsd:string {name="markers in reference data on Allen Brain Cell Atlas"} property_value: STATO:0000416 "0.7647059" xsd:float property_value: STATO:0000663 "0.5508475" xsd:float [Term] id: CLM:5007973 name: Pcp2, Arhgef33 (NSforest). xref: https://doi.org/10.1101/2020.09.23.308932 is_a: SO:0001260 ! 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sequence_collection relationship: BFO:0000051 http://identifiers.org/ncbigene/14399 ! has part Gabra6 (Mmus) relationship: BFO:0000051 http://identifiers.org/ncbigene/56410 ! has part Cbln3 (Mmus) property_value: CLM:0010004 "0.632" xsd:string property_value: IAO:0000064 "NSforest" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#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%2FH4OCCX8DhKAah4TEPdkEMk5RVElFN1RBTVA4UFFBSE80UAAFga%2BmSoHprA6BoIFHgJLV6AYABwAABQIBR2FicmE2AAABQ2JsbjMAAAYBAQJRWTVTOEtNTzVITEpVRjBQMDBLAAN%2BAAAABAAACFZGT0ZZUEZRR1JLVURRVVozRkYACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAVRMT0tXQ0w5NVJVMDNEOVBFVEcAAjczR1ZURFhERUdFMjdNMlhKTVQAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAgMA" xsd:string {name="markers in reference data on Allen Brain Cell Atlas"} property_value: STATO:0000416 "0.92941177" xsd:float property_value: STATO:0000663 "0.8494624" xsd:float [Term] id: CLM:5007975 name: Sln, Fat2 (NSforest). xref: https://doi.org/10.1101/2020.09.23.308932 is_a: SO:0001260 ! 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sequence_collection relationship: BFO:0000051 http://identifiers.org/ncbigene/11606 ! has part Agt (Mmus) relationship: BFO:0000051 http://identifiers.org/ncbigene/11668 ! has part Aldh1a1 (Mmus) relationship: BFO:0000051 http://identifiers.org/ncbigene/170790 ! has part Mlc1 (Mmus) property_value: CLM:0010004 "0.5021367521367521" xsd:string property_value: IAO:0000064 "NSforest" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIBMzE4IEFzdHJvLU5UIE5OAAABMTVCSzQ3RENJT0YxU0xMVVc5UAACAAABQ0JHQzBVMzBWVjlKUFI2MFRKVQACAAAEAQECgazGjoGWFSADhGpN%2FYRYGE0ABQMBQWd0AAABQWxkaDFhMQAAAU1sYzEAAAYBAQJRWTVTOEtNTzVITEpVRjBQMDBLAAN%2BAAAABAAACEc0STRHRkpYSkI5QVRaM1BUWDEACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAW5vbmUAAm5vbmUAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAUs5Sk4yM1AyNEtRQ0dLOVU3NUEAAkhTWVpQWlcxNjY5VTgyMUJXWVAAAwQBRlMwMERYVjBUOVIxWDlGSjRRRQACAAABUVk1UzhLTU81SExKVUYwUDAwSwACATMxOCBBc3Ryby1OVCBOTgAAATE1Qks0N0RDSU9GMVNMTFVXOVAAAgAAAUNCR0MwVTMwVlY5SlBSNjBUSlUAAgAABAEAAoRQvx%2BDggl%2FA4SgGoeExD3ZBDJOUVRJRTdUQU1QOFBRQUhPNFAABYGvpkqB6awOgaCBR4CS1egGAAcAAAUDAUFndAAAAUFsZGgxYTEAAAFNbGMxAAAGAQECUVk1UzhLTU81SExKVUYwUDAwSwADfgAAAAQAAAhWRk9GWVBGUUdSS1VEUVVaM0ZGAAlMVkRCSkFXOEJJNVlTUzFRVUJHAAoACwFUTE9LV0NMOTVSVTAzRDlQRVRHAAI3M0dWVERYREVHRTI3TTJYSk1UAAMBBAEAAiMwMDAwMDAAA8gBAAUBAQIjMDAwMDAwAAPIAQAAAAIDAA%3D%3D" xsd:string {name="markers in reference data on Allen Brain Cell Atlas"} property_value: STATO:0000416 "0.77557755" xsd:float property_value: STATO:0000663 "0.6994048" xsd:float [Term] id: CLM:5007979 name: Mfge8, Htra1, Fam107a (NSforest). xref: https://doi.org/10.1101/2020.09.23.308932 is_a: SO:0001260 ! sequence_collection relationship: BFO:0000051 http://identifiers.org/ncbigene/17304 ! has part Mfge8 (Mmus) relationship: BFO:0000051 http://identifiers.org/ncbigene/268709 ! has part Fam107a (Mmus) relationship: BFO:0000051 http://identifiers.org/ncbigene/56213 ! has part Htra1 (Mmus) property_value: CLM:0010004 "0.3836065573770492" xsd:string property_value: IAO:0000064 "NSforest" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIBMzE5IEFzdHJvLVRFIE5OAAABMTVCSzQ3RENJT0YxU0xMVVc5UAACAAABQ0JHQzBVMzBWVjlKUFI2MFRKVQACAAAEAQECgazGjoGWFSADhGpN%2FYRYGE0ABQMBTWZnZTgAAAFIdHJhMQAAAUZhbTEwN2EAAAYBAQJRWTVTOEtNTzVITEpVRjBQMDBLAAN%2BAAAABAAACEc0STRHRkpYSkI5QVRaM1BUWDEACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAW5vbmUAAm5vbmUAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAUs5Sk4yM1AyNEtRQ0dLOVU3NUEAAkhTWVpQWlcxNjY5VTgyMUJXWVAAAwQBRlMwMERYVjBUOVIxWDlGSjRRRQACAAABUVk1UzhLTU81SExKVUYwUDAwSwACATMxOSBBc3Ryby1URSBOTgAAATE1Qks0N0RDSU9GMVNMTFVXOVAAAgAAAUNCR0MwVTMwVlY5SlBSNjBUSlUAAgAABAEAAoRQvx%2BDggl%2FA4SgGoeExD3ZBDJOUVRJRTdUQU1QOFBRQUhPNFAABYGvpkqB6awOgaCBR4CS1egGAAcAAAUDAU1mZ2U4AAABSHRyYTEAAAFGYW0xMDdhAAAGAQECUVk1UzhLTU81SExKVUYwUDAwSwADfgAAAAQAAAhWRk9GWVBGUUdSS1VEUVVaM0ZGAAlMVkRCSkFXOEJJNVlTUzFRVUJHAAoACwFUTE9LV0NMOTVSVTAzRDlQRVRHAAI3M0dWVERYREVHRTI3TTJYSk1UAAMBBAEAAiMwMDAwMDAAA8gBAAUBAQIjMDAwMDAwAAPIAQAAAAIDAA%3D%3D" xsd:string {name="markers in reference data on Allen Brain Cell Atlas"} property_value: STATO:0000416 "0.6666667" xsd:float property_value: STATO:0000663 "0.58093345" xsd:float [Term] id: CLM:5007980 name: Islr, Gldc (NSforest). xref: https://doi.org/10.1101/2020.09.23.308932 is_a: SO:0001260 ! sequence_collection relationship: BFO:0000051 http://identifiers.org/ncbigene/104174 ! has part Gldc (Mmus) relationship: BFO:0000051 http://identifiers.org/ncbigene/26968 ! has part Islr (Mmus) property_value: CLM:0010004 "0.36" xsd:string property_value: IAO:0000064 "NSforest" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#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%2FH4OCCX8DhKAah4TEPdkEMk5RVElFN1RBTVA4UFFBSE80UAAFga%2BmSoHprA6BoIFHgJLV6AYABwAABQIBSXNscgAAAUdsZGMAAAYBAQJRWTVTOEtNTzVITEpVRjBQMDBLAAN%2BAAAABAAACFZGT0ZZUEZRR1JLVURRVVozRkYACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAVRMT0tXQ0w5NVJVMDNEOVBFVEcAAjczR1ZURFhERUdFMjdNMlhKTVQAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAgMA" xsd:string {name="markers in reference data on Allen Brain Cell Atlas"} property_value: STATO:0000416 "0.8780488" xsd:float property_value: STATO:0000663 "0.6818182" xsd:float [Term] id: CLM:5007982 name: Gpr50, S100a6 (NSforest). xref: https://doi.org/10.1101/2020.09.23.308932 is_a: SO:0001260 ! sequence_collection relationship: BFO:0000051 http://identifiers.org/ncbigene/14765 ! has part Gpr50 (Mmus) relationship: BFO:0000051 http://identifiers.org/ncbigene/20200 ! has part S100a6 (Mmus) property_value: CLM:0010004 "0.4520547945205479" xsd:string property_value: IAO:0000064 "NSforest" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIBMzIyIFRhbnljeXRlIE5OAAABMTVCSzQ3RENJT0YxU0xMVVc5UAACAAABQ0JHQzBVMzBWVjlKUFI2MFRKVQACAAAEAQECgazGjoGWFSADhGpN%2FYRYGE0ABQIBR3ByNTAAAAFTMTAwYTYAAAYBAQJRWTVTOEtNTzVITEpVRjBQMDBLAAN%2BAAAABAAACEc0STRHRkpYSkI5QVRaM1BUWDEACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAW5vbmUAAm5vbmUAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAUs5Sk4yM1AyNEtRQ0dLOVU3NUEAAkhTWVpQWlcxNjY5VTgyMUJXWVAAAwQBRlMwMERYVjBUOVIxWDlGSjRRRQACAAABUVk1UzhLTU81SExKVUYwUDAwSwACATMyMiBUYW55Y3l0ZSBOTgAAATE1Qks0N0RDSU9GMVNMTFVXOVAAAgAAAUNCR0MwVTMwVlY5SlBSNjBUSlUAAgAABAEAAoRQvx%2BDggl%2FA4SgGoeExD3ZBDJOUVRJRTdUQU1QOFBRQUhPNFAABYGvpkqB6awOgaCBR4CS1egGAAcAAAUCAUdwcjUwAAABUzEwMGE2AAAGAQECUVk1UzhLTU81SExKVUYwUDAwSwADfgAAAAQAAAhWRk9GWVBGUUdSS1VEUVVaM0ZGAAlMVkRCSkFXOEJJNVlTUzFRVUJHAAoACwFUTE9LV0NMOTVSVTAzRDlQRVRHAAI3M0dWVERYREVHRTI3TTJYSk1UAAMBBAEAAiMwMDAwMDAAA8gBAAUBAQIjMDAwMDAwAAPIAQAAAAIDAA%3D%3D" xsd:string {name="markers in reference data on Allen Brain Cell Atlas"} property_value: STATO:0000416 "0.94827586" xsd:float property_value: STATO:0000663 "0.77756834" xsd:float [Term] id: CLM:5007983 name: Ccdc153, Tmem212 (NSforest). xref: https://doi.org/10.1101/2020.09.23.308932 is_a: SO:0001260 ! sequence_collection relationship: BFO:0000051 http://identifiers.org/ncbigene/208613 ! has part Tmem212 (Mmus) relationship: BFO:0000051 http://identifiers.org/ncbigene/270150 ! has part Ccdc153 (Mmus) property_value: CLM:0010004 "0.9199288256227758" xsd:string property_value: IAO:0000064 "NSforest" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#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%2FH4OCCX8DhKAah4TEPdkEMk5RVElFN1RBTVA4UFFBSE80UAAFga%2BmSoHprA6BoIFHgJLV6AYABwAABQIBQ2NkYzE1MwAAAVRtZW0yMTIAAAYBAQJRWTVTOEtNTzVITEpVRjBQMDBLAAN%2BAAAABAAACFZGT0ZZUEZRR1JLVURRVVozRkYACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAVRMT0tXQ0w5NVJVMDNEOVBFVEcAAjczR1ZURFhERUdFMjdNMlhKTVQAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAgMA" xsd:string {name="markers in reference data on Allen Brain Cell Atlas"} property_value: STATO:0000416 "0.99232244" xsd:float property_value: STATO:0000663 "0.97694635" xsd:float [Term] id: CLM:5007984 name: Spp2, Mlc1 (NSforest). xref: https://doi.org/10.1101/2020.09.23.308932 is_a: SO:0001260 ! 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sequence_collection relationship: BFO:0000051 http://identifiers.org/ncbigene/18417 ! has part Cldn11 (Mmus) relationship: BFO:0000051 http://identifiers.org/ncbigene/338521 ! has part Fa2h (Mmus) property_value: CLM:0010004 "0.7349693251533742" xsd:string property_value: IAO:0000064 "NSforest" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIBMzI3IE9saWdvIE5OAAABMTVCSzQ3RENJT0YxU0xMVVc5UAACAAABQ0JHQzBVMzBWVjlKUFI2MFRKVQACAAAEAQECgazGjoGWFSADhGpN%2FYRYGE0ABQIBRmEyaAAAAUNsZG4xMQAABgEBAlFZNVM4S01PNUhMSlVGMFAwMEsAA34AAAAEAAAIRzRJNEdGSlhKQjlBVFozUFRYMQAJTFZEQkpBVzhCSTVZU1MxUVVCRwAKAAsBbm9uZQACbm9uZQADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAABSzlKTjIzUDI0S1FDR0s5VTc1QQACSFNZWlBaVzE2NjlVODIxQldZUAADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIBMzI3IE9saWdvIE5OAAABMTVCSzQ3RENJT0YxU0xMVVc5UAACAAABQ0JHQzBVMzBWVjlKUFI2MFRKVQACAAAEAQAChFC%2FH4OCCX8DhKAah4TEPdkEMk5RVElFN1RBTVA4UFFBSE80UAAFga%2BmSoHprA6BoIFHgJLV6AYABwAABQIBRmEyaAAAAUNsZG4xMQAABgEBAlFZNVM4S01PNUhMSlVGMFAwMEsAA34AAAAEAAAIVkZPRllQRlFHUktVRFFVWjNGRgAJTFZEQkpBVzhCSTVZU1MxUVVCRwAKAAsBVExPS1dDTDk1UlUwM0Q5UEVURwACNzNHVlREWERFR0UyN00yWEpNVAADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAACAwA%3D" xsd:string {name="markers in reference data on Allen Brain Cell Atlas"} property_value: STATO:0000416 "0.9868204" xsd:float property_value: STATO:0000663 "0.9235276" xsd:float [Term] id: CLM:5007988 name: Frzb, Apod (NSforest). xref: https://doi.org/10.1101/2020.09.23.308932 is_a: SO:0001260 ! sequence_collection relationship: BFO:0000051 http://identifiers.org/ncbigene/11815 ! has part Apod (Mmus) relationship: BFO:0000051 http://identifiers.org/ncbigene/20378 ! has part Frzb (Mmus) property_value: CLM:0010004 "0.69" xsd:string property_value: IAO:0000064 "NSforest" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#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%2FH4OCCX8DhKAah4TEPdkEMk5RVElFN1RBTVA4UFFBSE80UAAFga%2BmSoHprA6BoIFHgJLV6AYABwAABQIBRnJ6YgAAAUFwb2QAAAYBAQJRWTVTOEtNTzVITEpVRjBQMDBLAAN%2BAAAABAAACFZGT0ZZUEZRR1JLVURRVVozRkYACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAVRMT0tXQ0w5NVJVMDNEOVBFVEcAAjczR1ZURFhERUdFMjdNMlhKTVQAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAgMA" xsd:string {name="markers in reference data on Allen Brain Cell Atlas"} property_value: STATO:0000416 "0.9928058" xsd:float property_value: STATO:0000663 "0.9126984" xsd:float [Term] id: CLM:5007989 name: Prg4 (NSforest). xref: https://doi.org/10.1101/2020.09.23.308932 is_a: SO:0001260 ! sequence_collection relationship: BFO:0000051 http://identifiers.org/ncbigene/96875 ! has part Prg4 (Mmus) property_value: CLM:0010004 "0.7866666666666666" xsd:string property_value: IAO:0000064 "NSforest" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIBMzI5IEFCQyBOTgAAATE1Qks0N0RDSU9GMVNMTFVXOVAAAgAAAUNCR0MwVTMwVlY5SlBSNjBUSlUAAgAABAEBAoGsxo6BlhUgA4RqTf2EWBhNAAUBAVByZzQAAAYBAQJRWTVTOEtNTzVITEpVRjBQMDBLAAN%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%3D%3D" xsd:string {name="markers in reference data on Allen Brain Cell Atlas"} property_value: STATO:0000416 "0.98333335" xsd:float property_value: STATO:0000663 "0.93650794" xsd:float [Term] id: CLM:5007990 name: Slc6a13, Foxc1 (NSforest). xref: https://doi.org/10.1101/2020.09.23.308932 is_a: SO:0001260 ! sequence_collection relationship: BFO:0000051 http://identifiers.org/ncbigene/14412 ! has part Slc6a13 (Mmus) relationship: BFO:0000051 http://identifiers.org/ncbigene/17300 ! has part Foxc1 (Mmus) property_value: CLM:0010004 "0.575" xsd:string property_value: IAO:0000064 "NSforest" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIBMzMwIFZMTUMgTk4AAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIAAAFDQkdDMFUzMFZWOUpQUjYwVEpVAAIAAAQBAQKBrMaOgZYVIAOEak39hFgYTQAFAgFTbGM2YTEzAAABRm94YzEAAAYBAQJRWTVTOEtNTzVITEpVRjBQMDBLAAN%2BAAAABAAACEc0STRHRkpYSkI5QVRaM1BUWDEACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAW5vbmUAAm5vbmUAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAUs5Sk4yM1AyNEtRQ0dLOVU3NUEAAkhTWVpQWlcxNjY5VTgyMUJXWVAAAwQBRlMwMERYVjBUOVIxWDlGSjRRRQACAAABUVk1UzhLTU81SExKVUYwUDAwSwACATMzMCBWTE1DIE5OAAABMTVCSzQ3RENJT0YxU0xMVVc5UAACAAABQ0JHQzBVMzBWVjlKUFI2MFRKVQACAAAEAQAChFC%2FH4OCCX8DhKAah4TEPdkEMk5RVElFN1RBTVA4UFFBSE80UAAFga%2BmSoHprA6BoIFHgJLV6AYABwAABQIBU2xjNmExMwAAAUZveGMxAAAGAQECUVk1UzhLTU81SExKVUYwUDAwSwADfgAAAAQAAAhWRk9GWVBGUUdSS1VEUVVaM0ZGAAlMVkRCSkFXOEJJNVlTUzFRVUJHAAoACwFUTE9LV0NMOTVSVTAzRDlQRVRHAAI3M0dWVERYREVHRTI3TTJYSk1UAAMBBAEAAiMwMDAwMDAAA8gBAAUBAQIjMDAwMDAwAAPIAQAAAAIDAA%3D%3D" xsd:string {name="markers in reference data on Allen Brain Cell Atlas"} property_value: STATO:0000416 "0.9745763" xsd:float property_value: STATO:0000663 "0.8556548" xsd:float [Term] id: CLM:5007994 name: Tmem119, Cx3cr1 (NSforest). xref: https://doi.org/10.1101/2020.09.23.308932 is_a: SO:0001260 ! sequence_collection relationship: BFO:0000051 http://identifiers.org/ncbigene/13051 ! has part Cx3cr1 (Mmus) relationship: BFO:0000051 http://identifiers.org/ncbigene/231633 ! has part Tmem119 (Mmus) property_value: CLM:0010004 "0.86" xsd:string property_value: IAO:0000064 "NSforest" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIBMzM0IE1pY3JvZ2xpYSBOTgAAATE1Qks0N0RDSU9GMVNMTFVXOVAAAgAAAUNCR0MwVTMwVlY5SlBSNjBUSlUAAgAABAEBAoGsxo6BlhUgA4RqTf2EWBhNAAUCAVRtZW0xMTkAAAFDeDNjcjEAAAYBAQJRWTVTOEtNTzVITEpVRjBQMDBLAAN%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%3D%3D" xsd:string {name="markers in reference data on Allen Brain Cell Atlas"} property_value: STATO:0000416 "1.0" xsd:float property_value: STATO:0000663 "0.9684685" xsd:float [Term] id: CLM:5007995 name: F13a1, Pf4 (NSforest). xref: https://doi.org/10.1101/2020.09.23.308932 is_a: SO:0001260 ! sequence_collection relationship: BFO:0000051 http://identifiers.org/ncbigene/56744 ! has part Pf4 (Mmus) relationship: BFO:0000051 http://identifiers.org/ncbigene/74145 ! has part F13a1 (Mmus) property_value: CLM:0010004 "0.92" xsd:string property_value: IAO:0000064 "NSforest" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#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%2FH4OCCX8DhKAah4TEPdkEMk5RVElFN1RBTVA4UFFBSE80UAAFga%2BmSoHprA6BoIFHgJLV6AYABwAABQIBRjEzYTEAAAFQZjQAAAYBAQJRWTVTOEtNTzVITEpVRjBQMDBLAAN%2BAAAABAAACFZGT0ZZUEZRR1JLVURRVVozRkYACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAVRMT0tXQ0w5NVJVMDNEOVBFVEcAAjczR1ZURFhERUdFMjdNMlhKTVQAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAgMA" xsd:string {name="markers in reference data on Allen Brain Cell Atlas"} property_value: STATO:0000416 "1.0" xsd:float property_value: STATO:0000663 "0.982906" xsd:float [Term] id: CLM:5016781 name: Rftn1,Iltifb (Yao - within subclass). xref: https://doi.org/10.1038/s41586-023-06812-z is_a: SO:0001260 ! sequence_collection relationship: BFO:0000051 http://identifiers.org/ncbigene/116849 ! has part Iltifb (Mmus) relationship: BFO:0000051 http://identifiers.org/ncbigene/76438 ! has part Rftn1 (Mmus) property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIBMTE0MSBEQ08gSWwyMiBHbHktR2FiYV8xAAABQ0JHQzBVMzBWVjlKUFI2MFRKVQACAAAEAQECgazGjoGWFSADhGpN%2FYRYGE0ABQIBUmZ0bjEAAAFJbHRpZmIAAAYBAQIxNUJLNDdEQ0lPRjFTTExVVzlQAAN%2BAAAABAAACEc0STRHRkpYSkI5QVRaM1BUWDEACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAW5vbmUAAm5vbmUAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAUs5Sk4yM1AyNEtRQ0dLOVU3NUEAAkhTWVpQWlcxNjY5VTgyMUJXWVAAAwQBRlMwMERYVjBUOVIxWDlGSjRRRQACAAABUVk1UzhLTU81SExKVUYwUDAwSwACAAABMTVCSzQ3RENJT0YxU0xMVVc5UAACATExNDEgRENPIElsMjIgR2x5LUdhYmFfMQAAAUNCR0MwVTMwVlY5SlBSNjBUSlUAAgAABAEAAoRQvx%2BDggl%2FA4SgGoeExD3ZBDJOUVRJRTdUQU1QOFBRQUhPNFAABYGvpkqB6awOgaCBR4CS1egGAAcAAAUCAVJmdG4xAAABSWx0aWZiAAAGAQECMTVCSzQ3RENJT0YxU0xMVVc5UAADfgAAAAQAAAhWRk9GWVBGUUdSS1VEUVVaM0ZGAAlMVkRCSkFXOEJJNVlTUzFRVUJHAAoACwFUTE9LV0NMOTVSVTAzRDlQRVRHAAI3M0dWVERYREVHRTI3TTJYSk1UAAMBBAEAAiMwMDAwMDAAA8gBAAUBAQIjMDAwMDAwAAPIAQAAAAIDAA%3D%3D" xsd:string {name="markers in reference data on Allen Brain Cell Atlas"} [Term] id: CLM:5016783 name: Cdh22 (Yao - within subclass). xref: https://doi.org/10.1038/s41586-023-06812-z is_a: SO:0001260 ! sequence_collection relationship: BFO:0000051 http://identifiers.org/ncbigene/104010 ! has part Cdh22 (Mmus) property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIBMTE0MyBEQ08gSWwyMiBHbHktR2FiYV8zAAABQ0JHQzBVMzBWVjlKUFI2MFRKVQACAAAEAQECgazGjoGWFSADhGpN%2FYRYGE0ABQEBQ2RoMjIAAAYBAQIxNUJLNDdEQ0lPRjFTTExVVzlQAAN%2BAAAABAAACEc0STRHRkpYSkI5QVRaM1BUWDEACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAW5vbmUAAm5vbmUAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAUs5Sk4yM1AyNEtRQ0dLOVU3NUEAAkhTWVpQWlcxNjY5VTgyMUJXWVAAAwQBRlMwMERYVjBUOVIxWDlGSjRRRQACAAABUVk1UzhLTU81SExKVUYwUDAwSwACAAABMTVCSzQ3RENJT0YxU0xMVVc5UAACATExNDMgRENPIElsMjIgR2x5LUdhYmFfMwAAAUNCR0MwVTMwVlY5SlBSNjBUSlUAAgAABAEAAoRQvx%2BDggl%2FA4SgGoeExD3ZBDJOUVRJRTdUQU1QOFBRQUhPNFAABYGvpkqB6awOgaCBR4CS1egGAAcAAAUBAUNkaDIyAAAGAQECMTVCSzQ3RENJT0YxU0xMVVc5UAADfgAAAAQAAAhWRk9GWVBGUUdSS1VEUVVaM0ZGAAlMVkRCSkFXOEJJNVlTUzFRVUJHAAoACwFUTE9LV0NMOTVSVTAzRDlQRVRHAAI3M0dWVERYREVHRTI3TTJYSk1UAAMBBAEAAiMwMDAwMDAAA8gBAAUBAQIjMDAwMDAwAAPIAQAAAAIDAA%3D%3D" xsd:string {name="markers in reference data on Allen Brain Cell Atlas"} [Term] id: CLM:5016784 name: Afap1l2,Coro6 (Yao - within subclass). xref: https://doi.org/10.1038/s41586-023-06812-z is_a: SO:0001260 ! sequence_collection relationship: BFO:0000051 http://identifiers.org/ncbigene/216961 ! has part Coro6 (Mmus) relationship: BFO:0000051 http://identifiers.org/ncbigene/226250 ! has part Afap1l2 (Mmus) property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#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%2BDggl%2FA4SgGoeExD3ZBDJOUVRJRTdUQU1QOFBRQUhPNFAABYGvpkqB6awOgaCBR4CS1egGAAcAAAUCAUFmYXAxbDIAAAFDb3JvNgAABgEBAjE1Qks0N0RDSU9GMVNMTFVXOVAAA34AAAAEAAAIVkZPRllQRlFHUktVRFFVWjNGRgAJTFZEQkpBVzhCSTVZU1MxUVVCRwAKAAsBVExPS1dDTDk1UlUwM0Q5UEVURwACNzNHVlREWERFR0UyN00yWEpNVAADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAACAwA%3D" xsd:string {name="markers in reference data on Allen Brain Cell Atlas"} [Term] id: CLM:5016785 name: P3h2,Lrrc38 (Yao - within subclass). xref: https://doi.org/10.1038/s41586-023-06812-z is_a: SO:0001260 ! sequence_collection relationship: BFO:0000051 http://identifiers.org/ncbigene/210530 ! has part P3h2 (Mmus) relationship: BFO:0000051 http://identifiers.org/ncbigene/242735 ! has part Lrrc38 (Mmus) property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIBMTE0NSBDQiBQTEkgR2x5LUdhYmFfMgAAAUNCR0MwVTMwVlY5SlBSNjBUSlUAAgAABAEBAoGsxo6BlhUgA4RqTf2EWBhNAAUCAVAzaDIAAAFMcnJjMzgAAAYBAQIxNUJLNDdEQ0lPRjFTTExVVzlQAAN%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%3D%3D" xsd:string {name="markers in reference data on Allen Brain Cell Atlas"} [Term] id: CLM:5016786 name: Gm20754 (Yao - within subclass). xref: https://doi.org/10.1038/s41586-023-06812-z is_a: SO:0001260 ! sequence_collection relationship: BFO:0000051 http://identifiers.org/ncbigene/626082 ! has part Gm20754 (Mmus) property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIBMTE0NiBDQiBQTEkgR2x5LUdhYmFfMwAAAUNCR0MwVTMwVlY5SlBSNjBUSlUAAgAABAEBAoGsxo6BlhUgA4RqTf2EWBhNAAUBAUdtMjA3NTQAAAYBAQIxNUJLNDdEQ0lPRjFTTExVVzlQAAN%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%3D%3D" xsd:string {name="markers in reference data on Allen Brain Cell Atlas"} [Term] id: CLM:5016788 name: Zfp385c,Tfap2b (Yao - within subclass). xref: https://doi.org/10.1038/s41586-023-06812-z is_a: SO:0001260 ! sequence_collection relationship: BFO:0000051 http://identifiers.org/ncbigene/21419 ! has part Tfap2b (Mmus) relationship: BFO:0000051 http://identifiers.org/ncbigene/278304 ! has part Zfp385c (Mmus) property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIBMzEwIENCWCBHb2xnaSBHbHktR2FiYQAAATE1Qks0N0RDSU9GMVNMTFVXOVAAAgAAAUNCR0MwVTMwVlY5SlBSNjBUSlUAAgAABAEBAoGsxo6BlhUgA4RqTf2EWBhNAAUCAVpmcDM4NWMAAAFUZmFwMmIAAAYBAQJRWTVTOEtNTzVITEpVRjBQMDBLAAN%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%3D%3D" xsd:string {name="markers in reference data on Allen Brain Cell Atlas"} [Term] id: CLM:5016789 name: Pax2,Spns2 (Yao - within subclass). xref: https://doi.org/10.1038/s41586-023-06812-z is_a: SO:0001260 ! sequence_collection relationship: BFO:0000051 http://identifiers.org/ncbigene/18504 ! has part Pax2 (Mmus) relationship: BFO:0000051 http://identifiers.org/ncbigene/216892 ! has part Spns2 (Mmus) property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIBMTE0OSBDQlggTUxJIE1lZ2YxMSBHYWJhXzEAAAFDQkdDMFUzMFZWOUpQUjYwVEpVAAIAAAQBAQKBrMaOgZYVIAOEak39hFgYTQAFAgFQYXgyAAABU3BuczIAAAYBAQIxNUJLNDdEQ0lPRjFTTExVVzlQAAN%2BAAAABAAACEc0STRHRkpYSkI5QVRaM1BUWDEACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAW5vbmUAAm5vbmUAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAUs5Sk4yM1AyNEtRQ0dLOVU3NUEAAkhTWVpQWlcxNjY5VTgyMUJXWVAAAwQBRlMwMERYVjBUOVIxWDlGSjRRRQACAAABUVk1UzhLTU81SExKVUYwUDAwSwACAAABMTVCSzQ3RENJT0YxU0xMVVc5UAACATExNDkgQ0JYIE1MSSBNZWdmMTEgR2FiYV8xAAABQ0JHQzBVMzBWVjlKUFI2MFRKVQACAAAEAQAChFC%2FH4OCCX8DhKAah4TEPdkEMk5RVElFN1RBTVA4UFFBSE80UAAFga%2BmSoHprA6BoIFHgJLV6AYABwAABQIBUGF4MgAAAVNwbnMyAAAGAQECMTVCSzQ3RENJT0YxU0xMVVc5UAADfgAAAAQAAAhWRk9GWVBGUUdSS1VEUVVaM0ZGAAlMVkRCSkFXOEJJNVlTUzFRVUJHAAoACwFUTE9LV0NMOTVSVTAzRDlQRVRHAAI3M0dWVERYREVHRTI3TTJYSk1UAAMBBAEAAiMwMDAwMDAAA8gBAAUBAQIjMDAwMDAwAAPIAQAAAAIDAA%3D%3D" xsd:string {name="markers in reference data on Allen Brain Cell Atlas"} [Term] id: CLM:5016790 name: Gabra6 (Yao - within subclass). xref: https://doi.org/10.1038/s41586-023-06812-z is_a: SO:0001260 ! sequence_collection relationship: BFO:0000051 http://identifiers.org/ncbigene/14399 ! has part Gabra6 (Mmus) property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIBMTE1MCBDQlggTUxJIE1lZ2YxMSBHYWJhXzIAAAFDQkdDMFUzMFZWOUpQUjYwVEpVAAIAAAQBAQKBrMaOgZYVIAOEak39hFgYTQAFAQFHYWJyYTYAAAYBAQIxNUJLNDdEQ0lPRjFTTExVVzlQAAN%2BAAAABAAACEc0STRHRkpYSkI5QVRaM1BUWDEACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAW5vbmUAAm5vbmUAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAUs5Sk4yM1AyNEtRQ0dLOVU3NUEAAkhTWVpQWlcxNjY5VTgyMUJXWVAAAwQBRlMwMERYVjBUOVIxWDlGSjRRRQACAAABUVk1UzhLTU81SExKVUYwUDAwSwACAAABMTVCSzQ3RENJT0YxU0xMVVc5UAACATExNTAgQ0JYIE1MSSBNZWdmMTEgR2FiYV8yAAABQ0JHQzBVMzBWVjlKUFI2MFRKVQACAAAEAQAChFC%2FH4OCCX8DhKAah4TEPdkEMk5RVElFN1RBTVA4UFFBSE80UAAFga%2BmSoHprA6BoIFHgJLV6AYABwAABQEBR2FicmE2AAAGAQECMTVCSzQ3RENJT0YxU0xMVVc5UAADfgAAAAQAAAhWRk9GWVBGUUdSS1VEUVVaM0ZGAAlMVkRCSkFXOEJJNVlTUzFRVUJHAAoACwFUTE9LV0NMOTVSVTAzRDlQRVRHAAI3M0dWVERYREVHRTI3TTJYSk1UAAMBBAEAAiMwMDAwMDAAA8gBAAUBAQIjMDAwMDAwAAPIAQAAAAIDAA%3D%3D" xsd:string {name="markers in reference data on Allen Brain Cell Atlas"} [Term] id: CLM:5016792 name: Plcxd2,Fgf10 (Yao - within subclass). xref: https://doi.org/10.1038/s41586-023-06812-z is_a: SO:0001260 ! sequence_collection relationship: BFO:0000051 http://identifiers.org/ncbigene/14165 ! has part Fgf10 (Mmus) relationship: BFO:0000051 http://identifiers.org/ncbigene/433022 ! has part Plcxd2 (Mmus) property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIBMTE1MiBDQlggUHVya2luamUgR2FiYV8xAAABQ0JHQzBVMzBWVjlKUFI2MFRKVQACAAAEAQECgazGjoGWFSADhGpN%2FYRYGE0ABQIBUGxjeGQyAAABRmdmMTAAAAYBAQIxNUJLNDdEQ0lPRjFTTExVVzlQAAN%2BAAAABAAACEc0STRHRkpYSkI5QVRaM1BUWDEACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAW5vbmUAAm5vbmUAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAUs5Sk4yM1AyNEtRQ0dLOVU3NUEAAkhTWVpQWlcxNjY5VTgyMUJXWVAAAwQBRlMwMERYVjBUOVIxWDlGSjRRRQACAAABUVk1UzhLTU81SExKVUYwUDAwSwACAAABMTVCSzQ3RENJT0YxU0xMVVc5UAACATExNTIgQ0JYIFB1cmtpbmplIEdhYmFfMQAAAUNCR0MwVTMwVlY5SlBSNjBUSlUAAgAABAEAAoRQvx%2BDggl%2FA4SgGoeExD3ZBDJOUVRJRTdUQU1QOFBRQUhPNFAABYGvpkqB6awOgaCBR4CS1egGAAcAAAUCAVBsY3hkMgAAAUZnZjEwAAAGAQECMTVCSzQ3RENJT0YxU0xMVVc5UAADfgAAAAQAAAhWRk9GWVBGUUdSS1VEUVVaM0ZGAAlMVkRCSkFXOEJJNVlTUzFRVUJHAAoACwFUTE9LV0NMOTVSVTAzRDlQRVRHAAI3M0dWVERYREVHRTI3TTJYSk1UAAMBBAEAAiMwMDAwMDAAA8gBAAUBAQIjMDAwMDAwAAPIAQAAAAIDAA%3D%3D" xsd:string {name="markers in reference data on Allen Brain Cell Atlas"} [Term] id: CLM:5016793 name: Pcdh7,Grin2a,St6gal1 (Yao - within subclass). xref: https://doi.org/10.1038/s41586-023-06812-z is_a: SO:0001260 ! sequence_collection relationship: BFO:0000051 http://identifiers.org/ncbigene/14811 ! has part Grin2a (Mmus) relationship: BFO:0000051 http://identifiers.org/ncbigene/20440 ! has part St6gal1 (Mmus) relationship: BFO:0000051 http://identifiers.org/ncbigene/54216 ! has part Pcdh7 (Mmus) property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIBMTE1MyBDQlggUHVya2luamUgR2FiYV8yAAABQ0JHQzBVMzBWVjlKUFI2MFRKVQACAAAEAQECgazGjoGWFSADhGpN%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%2BAAAABAAACFZGT0ZZUEZRR1JLVURRVVozRkYACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAVRMT0tXQ0w5NVJVMDNEOVBFVEcAAjczR1ZURFhERUdFMjdNMlhKTVQAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAgMA" xsd:string {name="markers in reference data on Allen Brain Cell Atlas"} [Term] id: CLM:5016794 name: Cntn3 (Yao - within subclass). xref: https://doi.org/10.1038/s41586-023-06812-z is_a: SO:0001260 ! sequence_collection relationship: BFO:0000051 http://identifiers.org/ncbigene/18488 ! has part Cntn3 (Mmus) property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#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%2FH4OCCX8DhKAah4TEPdkEMk5RVElFN1RBTVA4UFFBSE80UAAFga%2BmSoHprA6BoIFHgJLV6AYABwAABQEBQ250bjMAAAYBAQIxNUJLNDdEQ0lPRjFTTExVVzlQAAN%2BAAAABAAACFZGT0ZZUEZRR1JLVURRVVozRkYACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAVRMT0tXQ0w5NVJVMDNEOVBFVEcAAjczR1ZURFhERUdFMjdNMlhKTVQAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAgMA" xsd:string {name="markers in reference data on Allen Brain Cell Atlas"} [Term] id: CLM:5016795 name: Gap43 (Yao - within subclass). xref: https://doi.org/10.1038/s41586-023-06812-z is_a: SO:0001260 ! sequence_collection relationship: BFO:0000051 http://identifiers.org/ncbigene/14432 ! has part Gap43 (Mmus) property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#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%2FH4OCCX8DhKAah4TEPdkEMk5RVElFN1RBTVA4UFFBSE80UAAFga%2BmSoHprA6BoIFHgJLV6AYABwAABQEBR2FwNDMAAAYBAQIxNUJLNDdEQ0lPRjFTTExVVzlQAAN%2BAAAABAAACFZGT0ZZUEZRR1JLVURRVVozRkYACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAVRMT0tXQ0w5NVJVMDNEOVBFVEcAAjczR1ZURFhERUdFMjdNMlhKTVQAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAgMA" xsd:string {name="markers in reference data on Allen Brain Cell Atlas"} [Term] id: CLM:5016796 name: Sln (Yao - within subclass). xref: https://doi.org/10.1038/s41586-023-06812-z is_a: SO:0001260 ! sequence_collection relationship: BFO:0000051 http://identifiers.org/ncbigene/66402 ! has part Sln (Mmus) property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#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%2BDggl%2FA4SgGoeExD3ZBDJOUVRJRTdUQU1QOFBRQUhPNFAABYGvpkqB6awOgaCBR4CS1egGAAcAAAUBAVNsbgAABgEBAlFZNVM4S01PNUhMSlVGMFAwMEsAA34AAAAEAAAIVkZPRllQRlFHUktVRFFVWjNGRgAJTFZEQkpBVzhCSTVZU1MxUVVCRwAKAAsBVExPS1dDTDk1UlUwM0Q5UEVURwACNzNHVlREWERFR0UyN00yWEpNVAADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAACAwA%3D" xsd:string {name="markers in reference data on Allen Brain Cell Atlas"} [Term] id: CLM:5016799 name: C4b,Prelp (Yao - within subclass). xref: https://doi.org/10.1038/s41586-023-06812-z is_a: SO:0001260 ! sequence_collection relationship: BFO:0000051 http://identifiers.org/ncbigene/116847 ! has part Prelp (Mmus) relationship: BFO:0000051 http://identifiers.org/ncbigene/12268 ! has part C4b (Mmus) property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIBMTE1OSBBc3Ryby1OVCBOTl8xAAABQ0JHQzBVMzBWVjlKUFI2MFRKVQACAAAEAQECgazGjoGWFSADhGpN%2FYRYGE0ABQIBQzRiAAABUHJlbHAAAAYBAQIxNUJLNDdEQ0lPRjFTTExVVzlQAAN%2BAAAABAAACEc0STRHRkpYSkI5QVRaM1BUWDEACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAW5vbmUAAm5vbmUAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAUs5Sk4yM1AyNEtRQ0dLOVU3NUEAAkhTWVpQWlcxNjY5VTgyMUJXWVAAAwQBRlMwMERYVjBUOVIxWDlGSjRRRQACAAABUVk1UzhLTU81SExKVUYwUDAwSwACAAABMTVCSzQ3RENJT0YxU0xMVVc5UAACATExNTkgQXN0cm8tTlQgTk5fMQAAAUNCR0MwVTMwVlY5SlBSNjBUSlUAAgAABAEAAoRQvx%2BDggl%2FA4SgGoeExD3ZBDJOUVRJRTdUQU1QOFBRQUhPNFAABYGvpkqB6awOgaCBR4CS1egGAAcAAAUCAUM0YgAAAVByZWxwAAAGAQECMTVCSzQ3RENJT0YxU0xMVVc5UAADfgAAAAQAAAhWRk9GWVBGUUdSS1VEUVVaM0ZGAAlMVkRCSkFXOEJJNVlTUzFRVUJHAAoACwFUTE9LV0NMOTVSVTAzRDlQRVRHAAI3M0dWVERYREVHRTI3TTJYSk1UAAMBBAEAAiMwMDAwMDAAA8gBAAUBAQIjMDAwMDAwAAPIAQAAAAIDAA%3D%3D" xsd:string {name="markers in reference data on Allen Brain Cell Atlas"} [Term] id: CLM:5016800 name: Slco1c1,Gria2,Shisa9 (Yao - within subclass). xref: https://doi.org/10.1038/s41586-023-06812-z is_a: SO:0001260 ! sequence_collection relationship: BFO:0000051 http://identifiers.org/ncbigene/14800 ! has part Gria2 (Mmus) relationship: BFO:0000051 http://identifiers.org/ncbigene/58807 ! has part Slco1c1 (Mmus) relationship: BFO:0000051 http://identifiers.org/ncbigene/72555 ! has part Shisa9 (Mmus) property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIBMTE2MCBBc3Ryby1OVCBOTl8yAAABQ0JHQzBVMzBWVjlKUFI2MFRKVQACAAAEAQECgazGjoGWFSADhGpN%2FYRYGE0ABQMBU2xjbzFjMQAAAUdyaWEyAAABU2hpc2E5AAAGAQECMTVCSzQ3RENJT0YxU0xMVVc5UAADfgAAAAQAAAhHNEk0R0ZKWEpCOUFUWjNQVFgxAAlMVkRCSkFXOEJJNVlTUzFRVUJHAAoACwFub25lAAJub25lAAMBBAEAAiMwMDAwMDAAA8gBAAUBAQIjMDAwMDAwAAPIAQAAAAFLOUpOMjNQMjRLUUNHSzlVNzVBAAJIU1laUFpXMTY2OVU4MjFCV1lQAAMEAUZTMDBEWFYwVDlSMVg5Rko0UUUAAgAAAVFZNVM4S01PNUhMSlVGMFAwMEsAAgAAATE1Qks0N0RDSU9GMVNMTFVXOVAAAgExMTYwIEFzdHJvLU5UIE5OXzIAAAFDQkdDMFUzMFZWOUpQUjYwVEpVAAIAAAQBAAKEUL8fg4IJfwOEoBqHhMQ92QQyTlFUSUU3VEFNUDhQUUFITzRQAAWBr6ZKgemsDoGggUeAktXoBgAHAAAFAwFTbGNvMWMxAAABR3JpYTIAAAFTaGlzYTkAAAYBAQIxNUJLNDdEQ0lPRjFTTExVVzlQAAN%2BAAAABAAACFZGT0ZZUEZRR1JLVURRVVozRkYACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAVRMT0tXQ0w5NVJVMDNEOVBFVEcAAjczR1ZURFhERUdFMjdNMlhKTVQAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAgMA" xsd:string {name="markers in reference data on Allen Brain Cell Atlas"} [Term] id: CLM:5016801 name: Myoc (Yao - within subclass). xref: https://doi.org/10.1038/s41586-023-06812-z is_a: SO:0001260 ! sequence_collection relationship: BFO:0000051 http://identifiers.org/ncbigene/17926 ! has part Myoc (Mmus) property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIBMTE2MSBBc3Ryby1URSBOTl8xAAABQ0JHQzBVMzBWVjlKUFI2MFRKVQACAAAEAQECgazGjoGWFSADhGpN%2FYRYGE0ABQEBTXlvYwAABgEBAjE1Qks0N0RDSU9GMVNMTFVXOVAAA34AAAAEAAAIRzRJNEdGSlhKQjlBVFozUFRYMQAJTFZEQkpBVzhCSTVZU1MxUVVCRwAKAAsBbm9uZQACbm9uZQADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAABSzlKTjIzUDI0S1FDR0s5VTc1QQACSFNZWlBaVzE2NjlVODIxQldZUAADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIBMTE2MSBBc3Ryby1URSBOTl8xAAABQ0JHQzBVMzBWVjlKUFI2MFRKVQACAAAEAQAChFC%2FH4OCCX8DhKAah4TEPdkEMk5RVElFN1RBTVA4UFFBSE80UAAFga%2BmSoHprA6BoIFHgJLV6AYABwAABQEBTXlvYwAABgEBAjE1Qks0N0RDSU9GMVNMTFVXOVAAA34AAAAEAAAIVkZPRllQRlFHUktVRFFVWjNGRgAJTFZEQkpBVzhCSTVZU1MxUVVCRwAKAAsBVExPS1dDTDk1UlUwM0Q5UEVURwACNzNHVlREWERFR0UyN00yWEpNVAADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAACAwA%3D" xsd:string {name="markers in reference data on Allen Brain Cell Atlas"} [Term] id: CLM:5016802 name: Zfp536,Hopx (Yao - within subclass). xref: https://doi.org/10.1038/s41586-023-06812-z is_a: SO:0001260 ! sequence_collection relationship: BFO:0000051 http://identifiers.org/ncbigene/243937 ! has part Zfp536 (Mmus) relationship: BFO:0000051 http://identifiers.org/ncbigene/74318 ! has part Hopx (Mmus) property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIBMTE2MiBBc3Ryby1URSBOTl8yAAABQ0JHQzBVMzBWVjlKUFI2MFRKVQACAAAEAQECgazGjoGWFSADhGpN%2FYRYGE0ABQIBWmZwNTM2AAABSG9weAAABgEBAjE1Qks0N0RDSU9GMVNMTFVXOVAAA34AAAAEAAAIRzRJNEdGSlhKQjlBVFozUFRYMQAJTFZEQkpBVzhCSTVZU1MxUVVCRwAKAAsBbm9uZQACbm9uZQADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAABSzlKTjIzUDI0S1FDR0s5VTc1QQACSFNZWlBaVzE2NjlVODIxQldZUAADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIBMTE2MiBBc3Ryby1URSBOTl8yAAABQ0JHQzBVMzBWVjlKUFI2MFRKVQACAAAEAQAChFC%2FH4OCCX8DhKAah4TEPdkEMk5RVElFN1RBTVA4UFFBSE80UAAFga%2BmSoHprA6BoIFHgJLV6AYABwAABQIBWmZwNTM2AAABSG9weAAABgEBAjE1Qks0N0RDSU9GMVNMTFVXOVAAA34AAAAEAAAIVkZPRllQRlFHUktVRFFVWjNGRgAJTFZEQkpBVzhCSTVZU1MxUVVCRwAKAAsBVExPS1dDTDk1UlUwM0Q5UEVURwACNzNHVlREWERFR0UyN00yWEpNVAADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAACAwA%3D" xsd:string {name="markers in reference data on Allen Brain Cell Atlas"} [Term] id: CLM:5016803 name: Brinp3,Hsd11b1,Grin2c (Yao - within subclass). xref: https://doi.org/10.1038/s41586-023-06812-z is_a: SO:0001260 ! sequence_collection relationship: BFO:0000051 http://identifiers.org/ncbigene/14813 ! has part Grin2c (Mmus) relationship: BFO:0000051 http://identifiers.org/ncbigene/15483 ! has part Hsd11b1 (Mmus) relationship: BFO:0000051 http://identifiers.org/ncbigene/215378 ! has part Brinp3 (Mmus) property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIBMTE2MyBBc3Ryby1URSBOTl8zAAABQ0JHQzBVMzBWVjlKUFI2MFRKVQACAAAEAQECgazGjoGWFSADhGpN%2FYRYGE0ABQMBQnJpbnAzAAABSHNkMTFiMQAAAUdyaW4yYwAABgEBAjE1Qks0N0RDSU9GMVNMTFVXOVAAA34AAAAEAAAIRzRJNEdGSlhKQjlBVFozUFRYMQAJTFZEQkpBVzhCSTVZU1MxUVVCRwAKAAsBbm9uZQACbm9uZQADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAABSzlKTjIzUDI0S1FDR0s5VTc1QQACSFNZWlBaVzE2NjlVODIxQldZUAADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIBMTE2MyBBc3Ryby1URSBOTl8zAAABQ0JHQzBVMzBWVjlKUFI2MFRKVQACAAAEAQAChFC%2FH4OCCX8DhKAah4TEPdkEMk5RVElFN1RBTVA4UFFBSE80UAAFga%2BmSoHprA6BoIFHgJLV6AYABwAABQMBQnJpbnAzAAABSHNkMTFiMQAAAUdyaW4yYwAABgEBAjE1Qks0N0RDSU9GMVNMTFVXOVAAA34AAAAEAAAIVkZPRllQRlFHUktVRFFVWjNGRgAJTFZEQkpBVzhCSTVZU1MxUVVCRwAKAAsBVExPS1dDTDk1UlUwM0Q5UEVURwACNzNHVlREWERFR0UyN00yWEpNVAADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAACAwA%3D" xsd:string {name="markers in reference data on Allen Brain Cell Atlas"} [Term] id: CLM:5016805 name: Sfrp1,Meis2,Retreg1 (Yao - within subclass). xref: https://doi.org/10.1038/s41586-023-06812-z is_a: SO:0001260 ! sequence_collection relationship: BFO:0000051 http://identifiers.org/ncbigene/17536 ! has part Meis2 (Mmus) relationship: BFO:0000051 http://identifiers.org/ncbigene/20377 ! has part Sfrp1 (Mmus) relationship: BFO:0000051 http://identifiers.org/ncbigene/66270 ! has part Retreg1 (Mmus) property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIBMTE2NSBBc3Ryby1URSBOTl81AAABQ0JHQzBVMzBWVjlKUFI2MFRKVQACAAAEAQECgazGjoGWFSADhGpN%2FYRYGE0ABQMBU2ZycDEAAAFNZWlzMgAAAVJldHJlZzEAAAYBAQIxNUJLNDdEQ0lPRjFTTExVVzlQAAN%2BAAAABAAACEc0STRHRkpYSkI5QVRaM1BUWDEACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAW5vbmUAAm5vbmUAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAUs5Sk4yM1AyNEtRQ0dLOVU3NUEAAkhTWVpQWlcxNjY5VTgyMUJXWVAAAwQBRlMwMERYVjBUOVIxWDlGSjRRRQACAAABUVk1UzhLTU81SExKVUYwUDAwSwACAAABMTVCSzQ3RENJT0YxU0xMVVc5UAACATExNjUgQXN0cm8tVEUgTk5fNQAAAUNCR0MwVTMwVlY5SlBSNjBUSlUAAgAABAEAAoRQvx%2BDggl%2FA4SgGoeExD3ZBDJOUVRJRTdUQU1QOFBRQUhPNFAABYGvpkqB6awOgaCBR4CS1egGAAcAAAUDAVNmcnAxAAABTWVpczIAAAFSZXRyZWcxAAAGAQECMTVCSzQ3RENJT0YxU0xMVVc5UAADfgAAAAQAAAhWRk9GWVBGUUdSS1VEUVVaM0ZGAAlMVkRCSkFXOEJJNVlTUzFRVUJHAAoACwFUTE9LV0NMOTVSVTAzRDlQRVRHAAI3M0dWVERYREVHRTI3TTJYSk1UAAMBBAEAAiMwMDAwMDAAA8gBAAUBAQIjMDAwMDAwAAPIAQAAAAIDAA%3D%3D" xsd:string {name="markers in reference data on Allen Brain Cell Atlas"} [Term] id: CLM:5016806 name: Greb1 4 (Yao - within subclass). xref: https://doi.org/10.1038/s41586-023-06812-z is_a: SO:0001260 ! sequence_collection relationship: BFO:0000051 http://identifiers.org/ncbigene/268527 ! has part Greb1 (Mmus) property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIBMTE2NiBBc3Ryby1PTEYgTk5fMQAAAUNCR0MwVTMwVlY5SlBSNjBUSlUAAgAABAEBAoGsxo6BlhUgA4RqTf2EWBhNAAUBAUdyZWIxIDQAAAYBAQIxNUJLNDdEQ0lPRjFTTExVVzlQAAN%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%3D%3D" xsd:string {name="markers in reference data on Allen Brain Cell Atlas"} [Term] id: CLM:5016807 name: C4b,Atp13a4 (Yao - within subclass). xref: https://doi.org/10.1038/s41586-023-06812-z is_a: SO:0001260 ! sequence_collection relationship: BFO:0000051 http://identifiers.org/ncbigene/12268 ! has part C4b (Mmus) relationship: BFO:0000051 http://identifiers.org/ncbigene/224079 ! has part Atp13a4 (Mmus) property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIBMTE2NyBBc3Ryby1PTEYgTk5fMgAAAUNCR0MwVTMwVlY5SlBSNjBUSlUAAgAABAEBAoGsxo6BlhUgA4RqTf2EWBhNAAUCAUM0YgAAAUF0cDEzYTQAAAYBAQIxNUJLNDdEQ0lPRjFTTExVVzlQAAN%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%3D%3D" xsd:string {name="markers in reference data on Allen Brain Cell Atlas"} [Term] id: CLM:5016808 name: C230072F16Rik (Yao - within subclass). xref: https://doi.org/10.1038/s41586-023-06812-z is_a: SO:0001260 ! sequence_collection relationship: BFO:0000051 http://identifiers.org/ncbigene/320784 ! has part C230072F16Rik (Mmus) property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIBMTE2OCBBc3Ryby1PTEYgTk5fMwAAAUNCR0MwVTMwVlY5SlBSNjBUSlUAAgAABAEBAoGsxo6BlhUgA4RqTf2EWBhNAAUBAUMyMzAwNzJGMTZSaWsAAAYBAQIxNUJLNDdEQ0lPRjFTTExVVzlQAAN%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%3D%3D" xsd:string {name="markers in reference data on Allen Brain Cell Atlas"} [Term] id: CLM:5016812 name: Lpl 4 (Yao - within subclass). xref: https://doi.org/10.1038/s41586-023-06812-z is_a: SO:0001260 ! sequence_collection relationship: BFO:0000051 http://identifiers.org/ncbigene/16956 ! has part Lpl (Mmus) property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIBMTE3MiBUYW55Y3l0ZSBOTl8xAAABQ0JHQzBVMzBWVjlKUFI2MFRKVQACAAAEAQECgazGjoGWFSADhGpN%2FYRYGE0ABQEBTHBsIDQAAAYBAQIxNUJLNDdEQ0lPRjFTTExVVzlQAAN%2BAAAABAAACEc0STRHRkpYSkI5QVRaM1BUWDEACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAW5vbmUAAm5vbmUAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAUs5Sk4yM1AyNEtRQ0dLOVU3NUEAAkhTWVpQWlcxNjY5VTgyMUJXWVAAAwQBRlMwMERYVjBUOVIxWDlGSjRRRQACAAABUVk1UzhLTU81SExKVUYwUDAwSwACAAABMTVCSzQ3RENJT0YxU0xMVVc5UAACATExNzIgVGFueWN5dGUgTk5fMQAAAUNCR0MwVTMwVlY5SlBSNjBUSlUAAgAABAEAAoRQvx%2BDggl%2FA4SgGoeExD3ZBDJOUVRJRTdUQU1QOFBRQUhPNFAABYGvpkqB6awOgaCBR4CS1egGAAcAAAUBAUxwbCA0AAAGAQECMTVCSzQ3RENJT0YxU0xMVVc5UAADfgAAAAQAAAhWRk9GWVBGUUdSS1VEUVVaM0ZGAAlMVkRCSkFXOEJJNVlTUzFRVUJHAAoACwFUTE9LV0NMOTVSVTAzRDlQRVRHAAI3M0dWVERYREVHRTI3TTJYSk1UAAMBBAEAAiMwMDAwMDAAA8gBAAUBAQIjMDAwMDAwAAPIAQAAAAIDAA%3D%3D" xsd:string {name="markers in reference data on Allen Brain Cell Atlas"} [Term] id: CLM:5016813 name: Grid1,Nkx2-4 (Yao - within subclass). xref: https://doi.org/10.1038/s41586-023-06812-z is_a: SO:0001260 ! sequence_collection relationship: BFO:0000051 http://identifiers.org/ncbigene/14803 ! has part Grid1 (Mmus) relationship: BFO:0000051 http://identifiers.org/ncbigene/228731 ! has part Nkx2-4 (Mmus) property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIBMTE3MyBUYW55Y3l0ZSBOTl8yAAABQ0JHQzBVMzBWVjlKUFI2MFRKVQACAAAEAQECgazGjoGWFSADhGpN%2FYRYGE0ABQIBR3JpZDEAAAFOa3gyLTQAAAYBAQIxNUJLNDdEQ0lPRjFTTExVVzlQAAN%2BAAAABAAACEc0STRHRkpYSkI5QVRaM1BUWDEACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAW5vbmUAAm5vbmUAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAUs5Sk4yM1AyNEtRQ0dLOVU3NUEAAkhTWVpQWlcxNjY5VTgyMUJXWVAAAwQBRlMwMERYVjBUOVIxWDlGSjRRRQACAAABUVk1UzhLTU81SExKVUYwUDAwSwACAAABMTVCSzQ3RENJT0YxU0xMVVc5UAACATExNzMgVGFueWN5dGUgTk5fMgAAAUNCR0MwVTMwVlY5SlBSNjBUSlUAAgAABAEAAoRQvx%2BDggl%2FA4SgGoeExD3ZBDJOUVRJRTdUQU1QOFBRQUhPNFAABYGvpkqB6awOgaCBR4CS1egGAAcAAAUCAUdyaWQxAAABTmt4Mi00AAAGAQECMTVCSzQ3RENJT0YxU0xMVVc5UAADfgAAAAQAAAhWRk9GWVBGUUdSS1VEUVVaM0ZGAAlMVkRCSkFXOEJJNVlTUzFRVUJHAAoACwFUTE9LV0NMOTVSVTAzRDlQRVRHAAI3M0dWVERYREVHRTI3TTJYSk1UAAMBBAEAAiMwMDAwMDAAA8gBAAUBAQIjMDAwMDAwAAPIAQAAAAIDAA%3D%3D" xsd:string {name="markers in reference data on Allen Brain Cell Atlas"} [Term] id: CLM:5016818 name: Ttr (Yao - within subclass). xref: https://doi.org/10.1038/s41586-023-06812-z is_a: SO:0001260 ! sequence_collection relationship: BFO:0000051 http://identifiers.org/ncbigene/22139 ! has part Ttr (Mmus) property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIBMzI1IENIT1IgTk4AAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIAAAFDQkdDMFUzMFZWOUpQUjYwVEpVAAIAAAQBAQKBrMaOgZYVIAOEak39hFgYTQAFAQFUdHIAAAYBAQJRWTVTOEtNTzVITEpVRjBQMDBLAAN%2BAAAABAAACEc0STRHRkpYSkI5QVRaM1BUWDEACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAW5vbmUAAm5vbmUAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAUs5Sk4yM1AyNEtRQ0dLOVU3NUEAAkhTWVpQWlcxNjY5VTgyMUJXWVAAAwQBRlMwMERYVjBUOVIxWDlGSjRRRQACAAABUVk1UzhLTU81SExKVUYwUDAwSwACATMyNSBDSE9SIE5OAAABMTVCSzQ3RENJT0YxU0xMVVc5UAACAAABQ0JHQzBVMzBWVjlKUFI2MFRKVQACAAAEAQAChFC%2FH4OCCX8DhKAah4TEPdkEMk5RVElFN1RBTVA4UFFBSE80UAAFga%2BmSoHprA6BoIFHgJLV6AYABwAABQEBVHRyAAAGAQECUVk1UzhLTU81SExKVUYwUDAwSwADfgAAAAQAAAhWRk9GWVBGUUdSS1VEUVVaM0ZGAAlMVkRCSkFXOEJJNVlTUzFRVUJHAAoACwFUTE9LV0NMOTVSVTAzRDlQRVRHAAI3M0dWVERYREVHRTI3TTJYSk1UAAMBBAEAAiMwMDAwMDAAA8gBAAUBAQIjMDAwMDAwAAPIAQAAAAIDAA%3D%3D" xsd:string {name="markers in reference data on Allen Brain Cell Atlas"} [Term] id: CLM:5016821 name: Bmp4 (Yao - within subclass). xref: https://doi.org/10.1038/s41586-023-06812-z is_a: SO:0001260 ! sequence_collection relationship: BFO:0000051 http://identifiers.org/ncbigene/12159 ! has part Bmp4 (Mmus) property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIBMTE4MSBDT1AgTk5fMQAAAUNCR0MwVTMwVlY5SlBSNjBUSlUAAgAABAEBAoGsxo6BlhUgA4RqTf2EWBhNAAUBAUJtcDQAAAYBAQIxNUJLNDdEQ0lPRjFTTExVVzlQAAN%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%3D%3D" xsd:string {name="markers in reference data on Allen Brain Cell Atlas"} [Term] id: CLM:5016822 name: Egflam,Man1a (Yao - within subclass). xref: https://doi.org/10.1038/s41586-023-06812-z is_a: SO:0001260 ! sequence_collection relationship: BFO:0000051 http://identifiers.org/ncbigene/17155 ! has part Man1a (Mmus) relationship: BFO:0000051 http://identifiers.org/ncbigene/268780 ! has part Egflam (Mmus) property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#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%3D" xsd:string {name="markers in reference data on Allen Brain Cell Atlas"} [Term] id: CLM:5016823 name: Cxcl12,2210011C24Rik (Yao - within subclass). xref: https://doi.org/10.1038/s41586-023-06812-z is_a: SO:0001260 ! sequence_collection relationship: BFO:0000051 http://identifiers.org/ncbigene/20315 ! has part Cxcl12 (Mmus) relationship: BFO:0000051 http://identifiers.org/ncbigene/70134 ! has part 2210011C24Rik (Mmus) property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#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%2BDggl%2FA4SgGoeExD3ZBDJOUVRJRTdUQU1QOFBRQUhPNFAABYGvpkqB6awOgaCBR4CS1egGAAcAAAUCAUN4Y2wxMgAAATIyMTAwMTFDMjRSaWsAAAYBAQIxNUJLNDdEQ0lPRjFTTExVVzlQAAN%2BAAAABAAACFZGT0ZZUEZRR1JLVURRVVozRkYACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAVRMT0tXQ0w5NVJVMDNEOVBFVEcAAjczR1ZURFhERUdFMjdNMlhKTVQAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAgMA" xsd:string {name="markers in reference data on Allen Brain Cell Atlas"} [Term] id: CLM:5016824 name: Efhd1,Spock3 (Yao - within subclass). xref: https://doi.org/10.1038/s41586-023-06812-z is_a: SO:0001260 ! sequence_collection relationship: BFO:0000051 http://identifiers.org/ncbigene/72902 ! has part Spock3 (Mmus) relationship: BFO:0000051 http://identifiers.org/ncbigene/98363 ! has part Efhd1 (Mmus) property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#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%2FH4OCCX8DhKAah4TEPdkEMk5RVElFN1RBTVA4UFFBSE80UAAFga%2BmSoHprA6BoIFHgJLV6AYABwAABQIBRWZoZDEAAAFTcG9jazMAAAYBAQIxNUJLNDdEQ0lPRjFTTExVVzlQAAN%2BAAAABAAACFZGT0ZZUEZRR1JLVURRVVozRkYACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAVRMT0tXQ0w5NVJVMDNEOVBFVEcAAjczR1ZURFhERUdFMjdNMlhKTVQAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAgMA" xsd:string {name="markers in reference data on Allen Brain Cell Atlas"} [Term] id: CLM:5016825 name: Aqp1,Foxd3 (Yao - within subclass). xref: https://doi.org/10.1038/s41586-023-06812-z is_a: SO:0001260 ! sequence_collection relationship: BFO:0000051 http://identifiers.org/ncbigene/11826 ! has part Aqp1 (Mmus) relationship: BFO:0000051 http://identifiers.org/ncbigene/15221 ! has part Foxd3 (Mmus) property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIBMzIgT0VDAAABUVk1UzhLTU81SExKVUYwUDAwSwACAAABMTVCSzQ3RENJT0YxU0xMVVc5UAACAAABQ0JHQzBVMzBWVjlKUFI2MFRKVQACAAAEAQECgazGjoGWFSADhGpN%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%2BAAAABAAACFZGT0ZZUEZRR1JLVURRVVozRkYACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAVRMT0tXQ0w5NVJVMDNEOVBFVEcAAjczR1ZURFhERUdFMjdNMlhKTVQAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAgMA" xsd:string {name="markers in reference data on Allen Brain Cell Atlas"} [Term] id: CLM:5016826 name: Slc47a1 (Yao - within subclass). xref: https://doi.org/10.1038/s41586-023-06812-z is_a: SO:0001260 ! sequence_collection relationship: BFO:0000051 http://identifiers.org/ncbigene/67473 ! has part Slc47a1 (Mmus) property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIBMzI5IEFCQyBOTgAAATE1Qks0N0RDSU9GMVNMTFVXOVAAAgAAAUNCR0MwVTMwVlY5SlBSNjBUSlUAAgAABAEBAoGsxo6BlhUgA4RqTf2EWBhNAAUBAVNsYzQ3YTEAAAYBAQJRWTVTOEtNTzVITEpVRjBQMDBLAAN%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%3D%3D" xsd:string {name="markers in reference data on Allen Brain Cell Atlas"} [Term] id: CLM:5016835 name: Pf4 (Yao - within subclass). xref: https://doi.org/10.1038/s41586-023-06812-z is_a: SO:0001260 ! sequence_collection relationship: BFO:0000051 http://identifiers.org/ncbigene/56744 ! has part Pf4 (Mmus) property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#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%2BDggl%2FA4SgGoeExD3ZBDJOUVRJRTdUQU1QOFBRQUhPNFAABYGvpkqB6awOgaCBR4CS1egGAAcAAAUBAVBmNAAABgEBAlFZNVM4S01PNUhMSlVGMFAwMEsAA34AAAAEAAAIVkZPRllQRlFHUktVRFFVWjNGRgAJTFZEQkpBVzhCSTVZU1MxUVVCRwAKAAsBVExPS1dDTDk1UlUwM0Q5UEVURwACNzNHVlREWERFR0UyN00yWEpNVAADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAACAwA%3D" xsd:string {name="markers in reference data on Allen Brain Cell Atlas"} [Term] id: CLM:5019534 name: Gnrh1 (Yao - within subclass). xref: https://doi.org/10.1038/s41586-023-06812-z is_a: SO:0001260 ! sequence_collection relationship: BFO:0000051 http://identifiers.org/ncbigene/14714 ! has part Gnrh1 (Mmus) property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#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%2FH4OCCX8DhKAah4TEPdkEMk5RVElFN1RBTVA4UFFBSE80UAAFga%2BmSoHprA6BoIFHgJLV6AYABwAABQEBR25yaDEAAAYBAQJGUzAwRFhWMFQ5UjFYOUZKNFFFAAN%2BAAAABAAACFZGT0ZZUEZRR1JLVURRVVozRkYACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAVRMT0tXQ0w5NVJVMDNEOVBFVEcAAjczR1ZURFhERUdFMjdNMlhKTVQAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAgMA" xsd:string {name="markers in reference data on Allen Brain Cell Atlas"} [Term] id: CLM:5021576 name: Cngb3,Ush2a (Yao - within subclass). xref: https://doi.org/10.1038/s41586-023-06812-z is_a: SO:0001260 ! sequence_collection relationship: BFO:0000051 http://identifiers.org/ncbigene/22283 ! has part Ush2a (Mmus) relationship: BFO:0000051 http://identifiers.org/ncbigene/30952 ! has part Cngb3 (Mmus) property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIBMjUgUGluZWFsIEdsdXQAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIAAAFDQkdDMFUzMFZWOUpQUjYwVEpVAAIAAAQBAQKBrMaOgZYVIAOEak39hFgYTQAFAgFDbmdiMwAAAVVzaDJhAAAGAQECRlMwMERYVjBUOVIxWDlGSjRRRQADfgAAAAQAAAhHNEk0R0ZKWEpCOUFUWjNQVFgxAAlMVkRCSkFXOEJJNVlTUzFRVUJHAAoACwFub25lAAJub25lAAMBBAEAAiMwMDAwMDAAA8gBAAUBAQIjMDAwMDAwAAPIAQAAAAFLOUpOMjNQMjRLUUNHSzlVNzVBAAJIU1laUFpXMTY2OVU4MjFCV1lQAAMEAUZTMDBEWFYwVDlSMVg5Rko0UUUAAgEyNSBQaW5lYWwgR2x1dAAAAVFZNVM4S01PNUhMSlVGMFAwMEsAAgAAATE1Qks0N0RDSU9GMVNMTFVXOVAAAgAAAUNCR0MwVTMwVlY5SlBSNjBUSlUAAgAABAEAAoRQvx%2BDggl%2FA4SgGoeExD3ZBDJOUVRJRTdUQU1QOFBRQUhPNFAABYGvpkqB6awOgaCBR4CS1egGAAcAAAUCAUNuZ2IzAAABVXNoMmEAAAYBAQJGUzAwRFhWMFQ5UjFYOUZKNFFFAAN%2BAAAABAAACFZGT0ZZUEZRR1JLVURRVVozRkYACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAVRMT0tXQ0w5NVJVMDNEOVBFVEcAAjczR1ZURFhERUdFMjdNMlhKTVQAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAgMA" xsd:string {name="markers in reference data on Allen Brain Cell Atlas"} [Term] id: CLM:5022142 name: Ppp1r17 4 (Yao - within subclass). xref: https://doi.org/10.1038/s41586-023-06812-z is_a: SO:0001260 ! sequence_collection relationship: BFO:0000051 http://identifiers.org/ncbigene/19051 ! has part Ppp1r17 (Mmus) property_value: CLM:0010004 "0.84" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIAAAFDQkdDMFUzMFZWOUpQUjYwVEpVAAIBNTE3MiBEQ08gSWwyMiBHbHktR2FiYV8yAAAEAQECgazGjoGWFSADhGpN%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%2BAAAABAAACFZGT0ZZUEZRR1JLVURRVVozRkYACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAVRMT0tXQ0w5NVJVMDNEOVBFVEcAAjczR1ZURFhERUdFMjdNMlhKTVQAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAgMA" xsd:string {name="markers in reference data on Allen Brain Cell Atlas"} property_value: STATO:0000416 "0.95454544" xsd:float property_value: STATO:0000663 "0.9292035" xsd:float [Term] id: CLM:5022155 name: Ly6d (Yao - within subclass). xref: https://doi.org/10.1038/s41586-023-06812-z is_a: SO:0001260 ! sequence_collection relationship: BFO:0000051 http://identifiers.org/ncbigene/17068 ! has part Ly6d (Mmus) property_value: CLM:0010004 "0.84" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIAAAFDQkdDMFUzMFZWOUpQUjYwVEpVAAIBNTE4NSBDQiBQTEkgR2x5LUdhYmFfNAAABAEBAoGsxo6BlhUgA4RqTf2EWBhNAAUBAUx5NmQAAAYBAQJDQkdDMFUzMFZWOUpQUjYwVEpVAAN%2BAAAABAAACEc0STRHRkpYSkI5QVRaM1BUWDEACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAW5vbmUAAm5vbmUAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAUs5Sk4yM1AyNEtRQ0dLOVU3NUEAAkhTWVpQWlcxNjY5VTgyMUJXWVAAAwQBRlMwMERYVjBUOVIxWDlGSjRRRQACAAABUVk1UzhLTU81SExKVUYwUDAwSwACAAABMTVCSzQ3RENJT0YxU0xMVVc5UAACAAABQ0JHQzBVMzBWVjlKUFI2MFRKVQACATUxODUgQ0IgUExJIEdseS1HYWJhXzQAAAQBAAKEUL8fg4IJfwOEoBqHhMQ92QQyTlFUSUU3VEFNUDhQUUFITzRQAAWBr6ZKgemsDoGggUeAktXoBgAHAAAFAQFMeTZkAAAGAQECQ0JHQzBVMzBWVjlKUFI2MFRKVQADfgAAAAQAAAhWRk9GWVBGUUdSS1VEUVVaM0ZGAAlMVkRCSkFXOEJJNVlTUzFRVUJHAAoACwFUTE9LV0NMOTVSVTAzRDlQRVRHAAI3M0dWVERYREVHRTI3TTJYSk1UAAMBBAEAAiMwMDAwMDAAA8gBAAUBAQIjMDAwMDAwAAPIAQAAAAIDAA%3D%3D" xsd:string {name="markers in reference data on Allen Brain Cell Atlas"} property_value: STATO:0000416 "0.9767442" xsd:float property_value: STATO:0000663 "0.9459459" xsd:float [Term] id: CLM:5022162 name: Cdh1,Acvr1c,Adamts15,Pax2 (Yao - within subclass). xref: https://doi.org/10.1038/s41586-023-06812-z is_a: SO:0001260 ! sequence_collection relationship: BFO:0000051 http://identifiers.org/ncbigene/12550 ! has part Cdh1 (Mmus) relationship: BFO:0000051 http://identifiers.org/ncbigene/18504 ! has part Pax2 (Mmus) relationship: BFO:0000051 http://identifiers.org/ncbigene/235130 ! has part Adamts15 (Mmus) relationship: BFO:0000051 http://identifiers.org/ncbigene/269275 ! has part Acvr1c (Mmus) property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIBMzEyIENCWCBNTEkgQ2RoMjIgR2FiYQAAATE1Qks0N0RDSU9GMVNMTFVXOVAAAgAAAUNCR0MwVTMwVlY5SlBSNjBUSlUAAgAABAEBAoGsxo6BlhUgA4RqTf2EWBhNAAUEAUNkaDEAAAFBY3ZyMWMAAAFBZGFtdHMxNQAAAVBheDIAAAYBAQJRWTVTOEtNTzVITEpVRjBQMDBLAAN%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%3D%3D" xsd:string {name="markers in reference data on Allen Brain Cell Atlas"} [Term] id: CLM:5022176 name: Gpr37l1,Ctxn3 (Yao - within subclass). xref: https://doi.org/10.1038/s41586-023-06812-z is_a: SO:0001260 ! sequence_collection relationship: BFO:0000051 http://identifiers.org/ncbigene/171469 ! has part Gpr37l1 (Mmus) relationship: BFO:0000051 http://identifiers.org/ncbigene/629147 ! has part Ctxn3 (Mmus) property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIBMzE2IEJlcmdtYW5uIE5OAAABMTVCSzQ3RENJT0YxU0xMVVc5UAACAAABQ0JHQzBVMzBWVjlKUFI2MFRKVQACAAAEAQECgazGjoGWFSADhGpN%2FYRYGE0ABQIBR3ByMzdsMQAAAUN0eG4zAAAGAQECUVk1UzhLTU81SExKVUYwUDAwSwADfgAAAAQAAAhHNEk0R0ZKWEpCOUFUWjNQVFgxAAlMVkRCSkFXOEJJNVlTUzFRVUJHAAoACwFub25lAAJub25lAAMBBAEAAiMwMDAwMDAAA8gBAAUBAQIjMDAwMDAwAAPIAQAAAAFLOUpOMjNQMjRLUUNHSzlVNzVBAAJIU1laUFpXMTY2OVU4MjFCV1lQAAMEAUZTMDBEWFYwVDlSMVg5Rko0UUUAAgAAAVFZNVM4S01PNUhMSlVGMFAwMEsAAgEzMTYgQmVyZ21hbm4gTk4AAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIAAAFDQkdDMFUzMFZWOUpQUjYwVEpVAAIAAAQBAAKEUL8fg4IJfwOEoBqHhMQ92QQyTlFUSUU3VEFNUDhQUUFITzRQAAWBr6ZKgemsDoGggUeAktXoBgAHAAAFAgFHcHIzN2wxAAABQ3R4bjMAAAYBAQJRWTVTOEtNTzVITEpVRjBQMDBLAAN%2BAAAABAAACFZGT0ZZUEZRR1JLVURRVVozRkYACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAVRMT0tXQ0w5NVJVMDNEOVBFVEcAAjczR1ZURFhERUdFMjdNMlhKTVQAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAgMA" xsd:string {name="markers in reference data on Allen Brain Cell Atlas"} [Term] id: CLM:5022177 name: Dao,Efemp1 (Yao - within subclass). xref: https://doi.org/10.1038/s41586-023-06812-z is_a: SO:0001260 ! sequence_collection relationship: BFO:0000051 http://identifiers.org/ncbigene/13142 ! has part Dao (Mmus) relationship: BFO:0000051 http://identifiers.org/ncbigene/216616 ! has part Efemp1 (Mmus) property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIBMzE3IEFzdHJvLUNCIE5OAAABMTVCSzQ3RENJT0YxU0xMVVc5UAACAAABQ0JHQzBVMzBWVjlKUFI2MFRKVQACAAAEAQECgazGjoGWFSADhGpN%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%2BAAAABAAACFZGT0ZZUEZRR1JLVURRVVozRkYACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAVRMT0tXQ0w5NVJVMDNEOVBFVEcAAjczR1ZURFhERUdFMjdNMlhKTVQAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAgMA" xsd:string {name="markers in reference data on Allen Brain Cell Atlas"} [Term] id: CLM:5022178 name: Galnt15 (Yao - within subclass). xref: https://doi.org/10.1038/s41586-023-06812-z is_a: SO:0001260 ! sequence_collection relationship: BFO:0000051 http://identifiers.org/ncbigene/78754 ! has part Galnt15 (Mmus) property_value: CLM:0010004 "0.74" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIAAAFDQkdDMFUzMFZWOUpQUjYwVEpVAAIBNTIwOCBBc3Ryby1OVCBOTl8xAAAEAQECgazGjoGWFSADhGpN%2FYRYGE0ABQEBR2FsbnQxNQAABgEBAkNCR0MwVTMwVlY5SlBSNjBUSlUAA34AAAAEAAAIRzRJNEdGSlhKQjlBVFozUFRYMQAJTFZEQkpBVzhCSTVZU1MxUVVCRwAKAAsBbm9uZQACbm9uZQADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAABSzlKTjIzUDI0S1FDR0s5VTc1QQACSFNZWlBaVzE2NjlVODIxQldZUAADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIAAAFDQkdDMFUzMFZWOUpQUjYwVEpVAAIBNTIwOCBBc3Ryby1OVCBOTl8xAAAEAQAChFC%2FH4OCCX8DhKAah4TEPdkEMk5RVElFN1RBTVA4UFFBSE80UAAFga%2BmSoHprA6BoIFHgJLV6AYABwAABQEBR2FsbnQxNQAABgEBAkNCR0MwVTMwVlY5SlBSNjBUSlUAA34AAAAEAAAIVkZPRllQRlFHUktVRFFVWjNGRgAJTFZEQkpBVzhCSTVZU1MxUVVCRwAKAAsBVExPS1dDTDk1UlUwM0Q5UEVURwACNzNHVlREWERFR0UyN00yWEpNVAADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAACAwA%3D" xsd:string {name="markers in reference data on Allen Brain Cell Atlas"} property_value: STATO:0000416 "0.74" xsd:float property_value: STATO:0000663 "0.74" xsd:float [Term] id: CLM:5022179 name: Slc36a2,Sfrp5 (Yao - within subclass). xref: https://doi.org/10.1038/s41586-023-06812-z is_a: SO:0001260 ! sequence_collection relationship: BFO:0000051 http://identifiers.org/ncbigene/246049 ! has part Slc36a2 (Mmus) relationship: BFO:0000051 http://identifiers.org/ncbigene/54612 ! has part Sfrp5 (Mmus) property_value: CLM:0010004 "0.16" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIAAAFDQkdDMFUzMFZWOUpQUjYwVEpVAAIBNTIwOSBBc3Ryby1OVCBOTl8xAAAEAQECgazGjoGWFSADhGpN%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%2BAAAABAAACFZGT0ZZUEZRR1JLVURRVVozRkYACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAVRMT0tXQ0w5NVJVMDNEOVBFVEcAAjczR1ZURFhERUdFMjdNMlhKTVQAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAgMA" xsd:string {name="markers in reference data on Allen Brain Cell Atlas"} property_value: STATO:0000416 "1.0" xsd:float property_value: STATO:0000663 "0.4878049" xsd:float [Term] id: CLM:5022180 name: Nuf2,Shroom3 (Yao - within subclass). xref: https://doi.org/10.1038/s41586-023-06812-z is_a: SO:0001260 ! sequence_collection relationship: BFO:0000051 http://identifiers.org/ncbigene/27428 ! has part Shroom3 (Mmus) relationship: BFO:0000051 http://identifiers.org/ncbigene/66977 ! has part Nuf2 (Mmus) property_value: CLM:0010004 "0.24" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIAAAFDQkdDMFUzMFZWOUpQUjYwVEpVAAIBNTIxMCBBc3Ryby1OVCBOTl8xAAAEAQECgazGjoGWFSADhGpN%2FYRYGE0ABQIBTnVmMgAAAVNocm9vbTMAAAYBAQJDQkdDMFUzMFZWOUpQUjYwVEpVAAN%2BAAAABAAACEc0STRHRkpYSkI5QVRaM1BUWDEACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAW5vbmUAAm5vbmUAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAUs5Sk4yM1AyNEtRQ0dLOVU3NUEAAkhTWVpQWlcxNjY5VTgyMUJXWVAAAwQBRlMwMERYVjBUOVIxWDlGSjRRRQACAAABUVk1UzhLTU81SExKVUYwUDAwSwACAAABMTVCSzQ3RENJT0YxU0xMVVc5UAACAAABQ0JHQzBVMzBWVjlKUFI2MFRKVQACATUyMTAgQXN0cm8tTlQgTk5fMQAABAEAAoRQvx%2BDggl%2FA4SgGoeExD3ZBDJOUVRJRTdUQU1QOFBRQUhPNFAABYGvpkqB6awOgaCBR4CS1egGAAcAAAUCAU51ZjIAAAFTaHJvb20zAAAGAQECQ0JHQzBVMzBWVjlKUFI2MFRKVQADfgAAAAQAAAhWRk9GWVBGUUdSS1VEUVVaM0ZGAAlMVkRCSkFXOEJJNVlTUzFRVUJHAAoACwFUTE9LV0NMOTVSVTAzRDlQRVRHAAI3M0dWVERYREVHRTI3TTJYSk1UAAMBBAEAAiMwMDAwMDAAA8gBAAUBAQIjMDAwMDAwAAPIAQAAAAIDAA%3D%3D" xsd:string {name="markers in reference data on Allen Brain Cell Atlas"} property_value: STATO:0000416 "0.6666667" xsd:float property_value: STATO:0000663 "0.4918033" xsd:float [Term] id: CLM:5022181 name: Six3os1 2 (Yao - within subclass). xref: https://doi.org/10.1038/s41586-023-06812-z is_a: SO:0001260 ! sequence_collection relationship: BFO:0000051 http://identifiers.org/ncbigene/100043902 ! has part Six3os1 (Mmus) property_value: CLM:0010004 "0.6" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIAAAFDQkdDMFUzMFZWOUpQUjYwVEpVAAIBNTIxMSBBc3Ryby1OVCBOTl8xAAAEAQECgazGjoGWFSADhGpN%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%2BAAAABAAACFZGT0ZZUEZRR1JLVURRVVozRkYACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAVRMT0tXQ0w5NVJVMDNEOVBFVEcAAjczR1ZURFhERUdFMjdNMlhKTVQAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAgMA" xsd:string {name="markers in reference data on Allen Brain Cell Atlas"} property_value: STATO:0000416 "0.6122449" xsd:float property_value: STATO:0000663 "0.6097561" xsd:float [Term] id: CLM:5022182 name: Kcnk10,C4b (Yao - within subclass). xref: https://doi.org/10.1038/s41586-023-06812-z is_a: SO:0001260 ! sequence_collection relationship: BFO:0000051 http://identifiers.org/ncbigene/12268 ! has part C4b (Mmus) relationship: BFO:0000051 http://identifiers.org/ncbigene/72258 ! has part Kcnk10 (Mmus) property_value: CLM:0010004 "0.04" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIAAAFDQkdDMFUzMFZWOUpQUjYwVEpVAAIBNTIxMiBBc3Ryby1OVCBOTl8xAAAEAQECgazGjoGWFSADhGpN%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%2BAAAABAAACFZGT0ZZUEZRR1JLVURRVVozRkYACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAVRMT0tXQ0w5NVJVMDNEOVBFVEcAAjczR1ZURFhERUdFMjdNMlhKTVQAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAgMA" xsd:string {name="markers in reference data on Allen Brain Cell Atlas"} property_value: STATO:0000416 "0.6666667" xsd:float property_value: STATO:0000663 "0.16129032" xsd:float [Term] id: CLM:5022183 name: Mecom,Prelp (Yao - within subclass). xref: https://doi.org/10.1038/s41586-023-06812-z is_a: SO:0001260 ! 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sequence_collection relationship: BFO:0000051 http://identifiers.org/ncbigene/101100 ! has part Ttll3 (Mmus) relationship: BFO:0000051 http://identifiers.org/ncbigene/14800 ! has part Gria2 (Mmus) relationship: BFO:0000051 http://identifiers.org/ncbigene/57265 ! has part Fzd2 (Mmus) property_value: CLM:0010004 "0.08" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIAAAFDQkdDMFUzMFZWOUpQUjYwVEpVAAIBNTIxNCBBc3Ryby1OVCBOTl8yAAAEAQECgazGjoGWFSADhGpN%2FYRYGE0ABQMBRnpkMgAAAUdyaWEyAAABVHRsbDMAAAYBAQJDQkdDMFUzMFZWOUpQUjYwVEpVAAN%2BAAAABAAACEc0STRHRkpYSkI5QVRaM1BUWDEACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAW5vbmUAAm5vbmUAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAUs5Sk4yM1AyNEtRQ0dLOVU3NUEAAkhTWVpQWlcxNjY5VTgyMUJXWVAAAwQBRlMwMERYVjBUOVIxWDlGSjRRRQACAAABUVk1UzhLTU81SExKVUYwUDAwSwACAAABMTVCSzQ3RENJT0YxU0xMVVc5UAACAAABQ0JHQzBVMzBWVjlKUFI2MFRKVQACATUyMTQgQXN0cm8tTlQgTk5fMgAABAEAAoRQvx%2BDggl%2FA4SgGoeExD3ZBDJOUVRJRTdUQU1QOFBRQUhPNFAABYGvpkqB6awOgaCBR4CS1egGAAcAAAUDAUZ6ZDIAAAFHcmlhMgAAAVR0bGwzAAAGAQECQ0JHQzBVMzBWVjlKUFI2MFRKVQADfgAAAAQAAAhWRk9GWVBGUUdSS1VEUVVaM0ZGAAlMVkRCSkFXOEJJNVlTUzFRVUJHAAoACwFUTE9LV0NMOTVSVTAzRDlQRVRHAAI3M0dWVERYREVHRTI3TTJYSk1UAAMBBAEAAiMwMDAwMDAAA8gBAAUBAQIjMDAwMDAwAAPIAQAAAAIDAA%3D%3D" xsd:string {name="markers in reference data on Allen Brain Cell Atlas"} property_value: STATO:0000416 "1.0" xsd:float property_value: STATO:0000663 "0.3030303" xsd:float [Term] id: CLM:5022185 name: Sez6l,Unc13c (Yao - within subclass). xref: https://doi.org/10.1038/s41586-023-06812-z is_a: SO:0001260 ! sequence_collection relationship: BFO:0000051 http://identifiers.org/ncbigene/208898 ! has part Unc13c (Mmus) relationship: BFO:0000051 http://identifiers.org/ncbigene/56747 ! has part Sez6l (Mmus) property_value: CLM:0010004 "0.14" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIAAAFDQkdDMFUzMFZWOUpQUjYwVEpVAAIBNTIxNSBBc3Ryby1OVCBOTl8yAAAEAQECgazGjoGWFSADhGpN%2FYRYGE0ABQIBU2V6NmwAAAFVbmMxM2MAAAYBAQJDQkdDMFUzMFZWOUpQUjYwVEpVAAN%2BAAAABAAACEc0STRHRkpYSkI5QVRaM1BUWDEACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAW5vbmUAAm5vbmUAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAUs5Sk4yM1AyNEtRQ0dLOVU3NUEAAkhTWVpQWlcxNjY5VTgyMUJXWVAAAwQBRlMwMERYVjBUOVIxWDlGSjRRRQACAAABUVk1UzhLTU81SExKVUYwUDAwSwACAAABMTVCSzQ3RENJT0YxU0xMVVc5UAACAAABQ0JHQzBVMzBWVjlKUFI2MFRKVQACATUyMTUgQXN0cm8tTlQgTk5fMgAABAEAAoRQvx%2BDggl%2FA4SgGoeExD3ZBDJOUVRJRTdUQU1QOFBRQUhPNFAABYGvpkqB6awOgaCBR4CS1egGAAcAAAUCAVNlejZsAAABVW5jMTNjAAAGAQECQ0JHQzBVMzBWVjlKUFI2MFRKVQADfgAAAAQAAAhWRk9GWVBGUUdSS1VEUVVaM0ZGAAlMVkRCSkFXOEJJNVlTUzFRVUJHAAoACwFUTE9LV0NMOTVSVTAzRDlQRVRHAAI3M0dWVERYREVHRTI3TTJYSk1UAAMBBAEAAiMwMDAwMDAAA8gBAAUBAQIjMDAwMDAwAAPIAQAAAAIDAA%3D%3D" xsd:string {name="markers in reference data on Allen Brain Cell Atlas"} property_value: STATO:0000416 "1.0" xsd:float property_value: STATO:0000663 "0.44871795" xsd:float [Term] id: CLM:5022186 name: Fam227b,Shroom3 (Yao - within subclass). xref: https://doi.org/10.1038/s41586-023-06812-z is_a: SO:0001260 ! sequence_collection relationship: BFO:0000051 http://identifiers.org/ncbigene/27428 ! has part Shroom3 (Mmus) relationship: BFO:0000051 http://identifiers.org/ncbigene/75823 ! has part Fam227b (Mmus) property_value: CLM:0010004 "0.08" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIAAAFDQkdDMFUzMFZWOUpQUjYwVEpVAAIBNTIxNiBBc3Ryby1OVCBOTl8yAAAEAQECgazGjoGWFSADhGpN%2FYRYGE0ABQIBRmFtMjI3YgAAAVNocm9vbTMAAAYBAQJDQkdDMFUzMFZWOUpQUjYwVEpVAAN%2BAAAABAAACEc0STRHRkpYSkI5QVRaM1BUWDEACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAW5vbmUAAm5vbmUAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAUs5Sk4yM1AyNEtRQ0dLOVU3NUEAAkhTWVpQWlcxNjY5VTgyMUJXWVAAAwQBRlMwMERYVjBUOVIxWDlGSjRRRQACAAABUVk1UzhLTU81SExKVUYwUDAwSwACAAABMTVCSzQ3RENJT0YxU0xMVVc5UAACAAABQ0JHQzBVMzBWVjlKUFI2MFRKVQACATUyMTYgQXN0cm8tTlQgTk5fMgAABAEAAoRQvx%2BDggl%2FA4SgGoeExD3ZBDJOUVRJRTdUQU1QOFBRQUhPNFAABYGvpkqB6awOgaCBR4CS1egGAAcAAAUCAUZhbTIyN2IAAAFTaHJvb20zAAAGAQECQ0JHQzBVMzBWVjlKUFI2MFRKVQADfgAAAAQAAAhWRk9GWVBGUUdSS1VEUVVaM0ZGAAlMVkRCSkFXOEJJNVlTUzFRVUJHAAoACwFUTE9LV0NMOTVSVTAzRDlQRVRHAAI3M0dWVERYREVHRTI3TTJYSk1UAAMBBAEAAiMwMDAwMDAAA8gBAAUBAQIjMDAwMDAwAAPIAQAAAAIDAA%3D%3D" xsd:string {name="markers in reference data on Allen Brain Cell Atlas"} property_value: STATO:0000416 "0.8" xsd:float property_value: STATO:0000663 "0.2857143" xsd:float [Term] id: CLM:5022187 name: Gm30524 (Yao - within subclass). xref: https://doi.org/10.1038/s41586-023-06812-z is_a: SO:0001260 ! sequence_collection relationship: BFO:0000051 http://identifiers.org/ncbigene/102632457 ! has part Gm30524 (Mmus) property_value: CLM:0010004 "0.52" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIAAAFDQkdDMFUzMFZWOUpQUjYwVEpVAAIBNTIxNyBBc3Ryby1OVCBOTl8yAAAEAQECgazGjoGWFSADhGpN%2FYRYGE0ABQEBR20zMDUyNAAABgEBAkNCR0MwVTMwVlY5SlBSNjBUSlUAA34AAAAEAAAIRzRJNEdGSlhKQjlBVFozUFRYMQAJTFZEQkpBVzhCSTVZU1MxUVVCRwAKAAsBbm9uZQACbm9uZQADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAABSzlKTjIzUDI0S1FDR0s5VTc1QQACSFNZWlBaVzE2NjlVODIxQldZUAADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIAAAFDQkdDMFUzMFZWOUpQUjYwVEpVAAIBNTIxNyBBc3Ryby1OVCBOTl8yAAAEAQAChFC%2FH4OCCX8DhKAah4TEPdkEMk5RVElFN1RBTVA4UFFBSE80UAAFga%2BmSoHprA6BoIFHgJLV6AYABwAABQEBR20zMDUyNAAABgEBAkNCR0MwVTMwVlY5SlBSNjBUSlUAA34AAAAEAAAIVkZPRllQRlFHUktVRFFVWjNGRgAJTFZEQkpBVzhCSTVZU1MxUVVCRwAKAAsBVExPS1dDTDk1UlUwM0Q5UEVURwACNzNHVlREWERFR0UyN00yWEpNVAADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAACAwA%3D" xsd:string {name="markers in reference data on Allen Brain Cell Atlas"} property_value: STATO:0000416 "0.5652174" xsd:float property_value: STATO:0000663 "0.5555556" xsd:float [Term] id: CLM:5022188 name: Myoc,Kcne1l,Alpk1 (Yao - within subclass). xref: https://doi.org/10.1038/s41586-023-06812-z is_a: SO:0001260 ! 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sequence_collection relationship: BFO:0000051 http://identifiers.org/ncbigene/17219 ! has part Mcm6 (Mmus) property_value: CLM:0010004 "0.8" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIAAAFDQkdDMFUzMFZWOUpQUjYwVEpVAAIBNTIyMyBBc3Ryby1URSBOTl8yAAAEAQECgazGjoGWFSADhGpN%2FYRYGE0ABQEBTWNtNgAABgEBAkNCR0MwVTMwVlY5SlBSNjBUSlUAA34AAAAEAAAIRzRJNEdGSlhKQjlBVFozUFRYMQAJTFZEQkpBVzhCSTVZU1MxUVVCRwAKAAsBbm9uZQACbm9uZQADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAABSzlKTjIzUDI0S1FDR0s5VTc1QQACSFNZWlBaVzE2NjlVODIxQldZUAADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIAAAFDQkdDMFUzMFZWOUpQUjYwVEpVAAIBNTIyMyBBc3Ryby1URSBOTl8yAAAEAQAChFC%2FH4OCCX8DhKAah4TEPdkEMk5RVElFN1RBTVA4UFFBSE80UAAFga%2BmSoHprA6BoIFHgJLV6AYABwAABQEBTWNtNgAABgEBAkNCR0MwVTMwVlY5SlBSNjBUSlUAA34AAAAEAAAIVkZPRllQRlFHUktVRFFVWjNGRgAJTFZEQkpBVzhCSTVZU1MxUVVCRwAKAAsBVExPS1dDTDk1UlUwM0Q5UEVURwACNzNHVlREWERFR0UyN00yWEpNVAADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAACAwA%3D" xsd:string {name="markers in reference data on Allen Brain Cell Atlas"} property_value: STATO:0000416 "0.44444445" xsd:float property_value: STATO:0000663 "0.4878049" xsd:float [Term] id: CLM:5022194 name: Cxcl5,Kif5a (Yao - within subclass). xref: https://doi.org/10.1038/s41586-023-06812-z is_a: SO:0001260 ! 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sequence_collection relationship: BFO:0000051 http://identifiers.org/ncbigene/320784 ! has part C230072F16Rik (Mmus) relationship: BFO:0000051 http://identifiers.org/ncbigene/77018 ! has part Col25a1 (Mmus) property_value: CLM:0010004 "0.54" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIAAAFDQkdDMFUzMFZWOUpQUjYwVEpVAAIBNTI0OSBUYW55Y3l0ZSBOTl8yAAAEAQECgazGjoGWFSADhGpN%2FYRYGE0ABQIBQ29sMjVhMQAAAUMyMzAwNzJGMTZSaWsAAAYBAQJDQkdDMFUzMFZWOUpQUjYwVEpVAAN%2BAAAABAAACEc0STRHRkpYSkI5QVRaM1BUWDEACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAW5vbmUAAm5vbmUAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAUs5Sk4yM1AyNEtRQ0dLOVU3NUEAAkhTWVpQWlcxNjY5VTgyMUJXWVAAAwQBRlMwMERYVjBUOVIxWDlGSjRRRQACAAABUVk1UzhLTU81SExKVUYwUDAwSwACAAABMTVCSzQ3RENJT0YxU0xMVVc5UAACAAABQ0JHQzBVMzBWVjlKUFI2MFRKVQACATUyNDkgVGFueWN5dGUgTk5fMgAABAEAAoRQvx%2BDggl%2FA4SgGoeExD3ZBDJOUVRJRTdUQU1QOFBRQUhPNFAABYGvpkqB6awOgaCBR4CS1egGAAcAAAUCAUNvbDI1YTEAAAFDMjMwMDcyRjE2UmlrAAAGAQECQ0JHQzBVMzBWVjlKUFI2MFRKVQADfgAAAAQAAAhWRk9GWVBGUUdSS1VEUVVaM0ZGAAlMVkRCSkFXOEJJNVlTUzFRVUJHAAoACwFUTE9LV0NMOTVSVTAzRDlQRVRHAAI3M0dWVERYREVHRTI3TTJYSk1UAAMBBAEAAiMwMDAwMDAAA8gBAAUBAQIjMDAwMDAwAAPIAQAAAAIDAA%3D%3D" xsd:string {name="markers in reference data on Allen Brain Cell Atlas"} property_value: STATO:0000416 "0.84375" xsd:float property_value: STATO:0000663 "0.75842696" xsd:float [Term] id: CLM:5022220 name: Ecrg4 (Yao - within subclass). xref: https://doi.org/10.1038/s41586-023-06812-z is_a: SO:0001260 ! sequence_collection relationship: BFO:0000051 http://identifiers.org/ncbigene/78896 ! has part Ecrg4 (Mmus) property_value: CLM:0010004 "0.6341463414634146" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIAAAFDQkdDMFUzMFZWOUpQUjYwVEpVAAIBNTI1MCBUYW55Y3l0ZSBOTl8zAAAEAQECgazGjoGWFSADhGpN%2FYRYGE0ABQEBRWNyZzQAAAYBAQJDQkdDMFUzMFZWOUpQUjYwVEpVAAN%2BAAAABAAACEc0STRHRkpYSkI5QVRaM1BUWDEACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAW5vbmUAAm5vbmUAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAUs5Sk4yM1AyNEtRQ0dLOVU3NUEAAkhTWVpQWlcxNjY5VTgyMUJXWVAAAwQBRlMwMERYVjBUOVIxWDlGSjRRRQACAAABUVk1UzhLTU81SExKVUYwUDAwSwACAAABMTVCSzQ3RENJT0YxU0xMVVc5UAACAAABQ0JHQzBVMzBWVjlKUFI2MFRKVQACATUyNTAgVGFueWN5dGUgTk5fMwAABAEAAoRQvx%2BDggl%2FA4SgGoeExD3ZBDJOUVRJRTdUQU1QOFBRQUhPNFAABYGvpkqB6awOgaCBR4CS1egGAAcAAAUBAUVjcmc0AAAGAQECQ0JHQzBVMzBWVjlKUFI2MFRKVQADfgAAAAQAAAhWRk9GWVBGUUdSS1VEUVVaM0ZGAAlMVkRCSkFXOEJJNVlTUzFRVUJHAAoACwFUTE9LV0NMOTVSVTAzRDlQRVRHAAI3M0dWVERYREVHRTI3TTJYSk1UAAMBBAEAAiMwMDAwMDAAA8gBAAUBAQIjMDAwMDAwAAPIAQAAAAIDAA%3D%3D" xsd:string {name="markers in reference data on Allen Brain Cell Atlas"} property_value: STATO:0000416 "0.44827586" xsd:float property_value: STATO:0000663 "0.47619048" xsd:float [Term] id: CLM:5022233 name: Sspo,Wfdc2 (Yao - within subclass). xref: https://doi.org/10.1038/s41586-023-06812-z is_a: SO:0001260 ! sequence_collection relationship: BFO:0000051 http://identifiers.org/ncbigene/243369 ! has part Sspo (Mmus) relationship: BFO:0000051 http://identifiers.org/ncbigene/67701 ! has part Wfdc2 (Mmus) property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIBMzI0IEh5cGVuZHltYWwgTk4AAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIAAAFDQkdDMFUzMFZWOUpQUjYwVEpVAAIAAAQBAQKBrMaOgZYVIAOEak39hFgYTQAFAgFTc3BvAAABV2ZkYzIAAAYBAQJRWTVTOEtNTzVITEpVRjBQMDBLAAN%2BAAAABAAACEc0STRHRkpYSkI5QVRaM1BUWDEACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAW5vbmUAAm5vbmUAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAUs5Sk4yM1AyNEtRQ0dLOVU3NUEAAkhTWVpQWlcxNjY5VTgyMUJXWVAAAwQBRlMwMERYVjBUOVIxWDlGSjRRRQACAAABUVk1UzhLTU81SExKVUYwUDAwSwACATMyNCBIeXBlbmR5bWFsIE5OAAABMTVCSzQ3RENJT0YxU0xMVVc5UAACAAABQ0JHQzBVMzBWVjlKUFI2MFRKVQACAAAEAQAChFC%2FH4OCCX8DhKAah4TEPdkEMk5RVElFN1RBTVA4UFFBSE80UAAFga%2BmSoHprA6BoIFHgJLV6AYABwAABQIBU3NwbwAAAVdmZGMyAAAGAQECUVk1UzhLTU81SExKVUYwUDAwSwADfgAAAAQAAAhWRk9GWVBGUUdSS1VEUVVaM0ZGAAlMVkRCSkFXOEJJNVlTUzFRVUJHAAoACwFUTE9LV0NMOTVSVTAzRDlQRVRHAAI3M0dWVERYREVHRTI3TTJYSk1UAAMBBAEAAiMwMDAwMDAAA8gBAAUBAQIjMDAwMDAwAAPIAQAAAAIDAA%3D%3D" xsd:string {name="markers in reference data on Allen Brain Cell Atlas"} [Term] id: CLM:5022234 name: Tbc1d1 (Yao - within subclass). xref: https://doi.org/10.1038/s41586-023-06812-z is_a: SO:0001260 ! 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sequence_collection relationship: BFO:0000051 http://identifiers.org/ncbigene/216227 ! has part Slc17a8 (Mmus) property_value: CLM:0010004 "0.6" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIAAAFDQkdDMFUzMFZWOUpQUjYwVEpVAAIBNTI2NSBDSE9SIE5OXzEAAAQBAQKBrMaOgZYVIAOEak39hFgYTQAFAQFTbGMxN2E4IDcAAAYBAQJDQkdDMFUzMFZWOUpQUjYwVEpVAAN%2BAAAABAAACEc0STRHRkpYSkI5QVRaM1BUWDEACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAW5vbmUAAm5vbmUAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAUs5Sk4yM1AyNEtRQ0dLOVU3NUEAAkhTWVpQWlcxNjY5VTgyMUJXWVAAAwQBRlMwMERYVjBUOVIxWDlGSjRRRQACAAABUVk1UzhLTU81SExKVUYwUDAwSwACAAABMTVCSzQ3RENJT0YxU0xMVVc5UAACAAABQ0JHQzBVMzBWVjlKUFI2MFRKVQACATUyNjUgQ0hPUiBOTl8xAAAEAQAChFC%2FH4OCCX8DhKAah4TEPdkEMk5RVElFN1RBTVA4UFFBSE80UAAFga%2BmSoHprA6BoIFHgJLV6AYABwAABQEBU2xjMTdhOCA3AAAGAQECQ0JHQzBVMzBWVjlKUFI2MFRKVQADfgAAAAQAAAhWRk9GWVBGUUdSS1VEUVVaM0ZGAAlMVkRCSkFXOEJJNVlTUzFRVUJHAAoACwFUTE9LV0NMOTVSVTAzRDlQRVRHAAI3M0dWVERYREVHRTI3TTJYSk1UAAMBBAEAAiMwMDAwMDAAA8gBAAUBAQIjMDAwMDAwAAPIAQAAAAIDAA%3D%3D" xsd:string {name="markers in reference data on Allen Brain Cell Atlas"} property_value: STATO:0000416 "0.9677419" xsd:float property_value: STATO:0000663 "0.86206895" xsd:float [Term] id: CLM:5022236 name: Neil3,Foxg1 (Yao - within subclass). xref: https://doi.org/10.1038/s41586-023-06812-z is_a: SO:0001260 ! 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sequence_collection relationship: BFO:0000051 http://identifiers.org/ncbigene/15228 ! has part Foxg1 (Mmus) relationship: BFO:0000051 http://identifiers.org/ncbigene/212377 ! has part Mms22l (Mmus) relationship: BFO:0000051 http://identifiers.org/ncbigene/21973 ! has part Top2a (Mmus) property_value: CLM:0010004 "0.1" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIAAAFDQkdDMFUzMFZWOUpQUjYwVEpVAAIBNTI2OCBPUEMgTk5fMQAABAEBAoGsxo6BlhUgA4RqTf2EWBhNAAUDAU1tczIybAAAAUZveGcxAAABVG9wMmEAAAYBAQJDQkdDMFUzMFZWOUpQUjYwVEpVAAN%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%3D%3D" xsd:string {name="markers in reference data on Allen Brain Cell Atlas"} property_value: STATO:0000416 "0.23809524" xsd:float property_value: STATO:0000663 "0.18656716" xsd:float [Term] id: CLM:5022239 name: Col27a1 (Yao - within subclass). xref: https://doi.org/10.1038/s41586-023-06812-z is_a: SO:0001260 ! sequence_collection relationship: BFO:0000051 http://identifiers.org/ncbigene/373864 ! has part Col27a1 (Mmus) property_value: CLM:0010004 "0.46" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIAAAFDQkdDMFUzMFZWOUpQUjYwVEpVAAIBNTI2OSBPUEMgTk5fMQAABAEBAoGsxo6BlhUgA4RqTf2EWBhNAAUBAUNvbDI3YTEAAAYBAQJDQkdDMFUzMFZWOUpQUjYwVEpVAAN%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%3D%3D" xsd:string {name="markers in reference data on Allen Brain Cell Atlas"} property_value: STATO:0000416 "0.40350878" xsd:float property_value: STATO:0000663 "0.41366908" xsd:float [Term] id: CLM:5022240 name: Rmi2,Col27a1 (Yao - within subclass). xref: https://doi.org/10.1038/s41586-023-06812-z is_a: SO:0001260 ! 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sequence_collection relationship: BFO:0000051 http://identifiers.org/ncbigene/12159 ! has part Bmp4 (Mmus) relationship: BFO:0000051 http://identifiers.org/ncbigene/214944 ! has part Mob3b (Mmus) property_value: CLM:0010004 "0.52" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#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%2BDggl%2FA4SgGoeExD3ZBDJOUVRJRTdUQU1QOFBRQUhPNFAABYGvpkqB6awOgaCBR4CS1egGAAcAAAUCAUJtcDQAAAFNb2IzYgAABgEBAkNCR0MwVTMwVlY5SlBSNjBUSlUAA34AAAAEAAAIVkZPRllQRlFHUktVRFFVWjNGRgAJTFZEQkpBVzhCSTVZU1MxUVVCRwAKAAsBVExPS1dDTDk1UlUwM0Q5UEVURwACNzNHVlREWERFR0UyN00yWEpNVAADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAACAwA%3D" xsd:string {name="markers in reference data on Allen Brain Cell Atlas"} property_value: STATO:0000416 "0.325" xsd:float property_value: STATO:0000663 "0.35135135" xsd:float [Term] id: CLM:5022246 name: Vwc2,Opalin (Yao - within subclass). xref: https://doi.org/10.1038/s41586-023-06812-z is_a: SO:0001260 ! sequence_collection relationship: BFO:0000051 http://identifiers.org/ncbigene/226115 ! has part Opalin (Mmus) relationship: BFO:0000051 http://identifiers.org/ncbigene/319922 ! has part Vwc2 (Mmus) property_value: CLM:0010004 "0.0" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIAAAFDQkdDMFUzMFZWOUpQUjYwVEpVAAIBNTI3NiBDT1AgTk5fMQAABAEBAoGsxo6BlhUgA4RqTf2EWBhNAAUCAVZ3YzIAAAFPcGFsaW4AAAYBAQJDQkdDMFUzMFZWOUpQUjYwVEpVAAN%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%3D%3D" xsd:string {name="markers in reference data on Allen Brain Cell Atlas"} property_value: STATO:0000416 "0.0" xsd:float property_value: STATO:0000663 "0.0" xsd:float [Term] id: CLM:5022247 name: Bmp4,Cck,Ptger1 (Yao - within subclass). xref: https://doi.org/10.1038/s41586-023-06812-z is_a: SO:0001260 ! sequence_collection relationship: BFO:0000051 http://identifiers.org/ncbigene/12159 ! has part Bmp4 (Mmus) relationship: BFO:0000051 http://identifiers.org/ncbigene/12424 ! has part Cck (Mmus) relationship: BFO:0000051 http://identifiers.org/ncbigene/19216 ! has part Ptger1 (Mmus) property_value: CLM:0010004 "0.08" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIAAAFDQkdDMFUzMFZWOUpQUjYwVEpVAAIBNTI3NyBDT1AgTk5fMQAABAEBAoGsxo6BlhUgA4RqTf2EWBhNAAUDAUJtcDQAAAFDY2sAAAFQdGdlcjEAAAYBAQJDQkdDMFUzMFZWOUpQUjYwVEpVAAN%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%3D%3D" xsd:string {name="markers in reference data on Allen Brain Cell Atlas"} property_value: STATO:0000416 "0.6666667" xsd:float property_value: STATO:0000663 "0.27027026" xsd:float [Term] id: CLM:5022248 name: 9630013A20Rik,Grin2b (Yao - within subclass). xref: https://doi.org/10.1038/s41586-023-06812-z is_a: SO:0001260 ! sequence_collection relationship: BFO:0000051 http://identifiers.org/ncbigene/14812 ! has part Grin2b (Mmus) relationship: BFO:0000051 http://identifiers.org/ncbigene/319903 ! has part 9630013A20Rik (Mmus) property_value: CLM:0010004 "0.6" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#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%2BDggl%2FA4SgGoeExD3ZBDJOUVRJRTdUQU1QOFBRQUhPNFAABYGvpkqB6awOgaCBR4CS1egGAAcAAAUCATk2MzAwMTNBMjBSaWsAAAFHcmluMmIAAAYBAQJDQkdDMFUzMFZWOUpQUjYwVEpVAAN%2BAAAABAAACFZGT0ZZUEZRR1JLVURRVVozRkYACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAVRMT0tXQ0w5NVJVMDNEOVBFVEcAAjczR1ZURFhERUdFMjdNMlhKTVQAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAgMA" xsd:string {name="markers in reference data on Allen Brain Cell Atlas"} property_value: STATO:0000416 "0.2647059" xsd:float property_value: STATO:0000663 "0.29801324" xsd:float [Term] id: CLM:5022249 name: Dbx2,Rassf10 (Yao - within subclass). xref: https://doi.org/10.1038/s41586-023-06812-z is_a: SO:0001260 ! sequence_collection relationship: BFO:0000051 http://identifiers.org/ncbigene/223843 ! has part Dbx2 (Mmus) relationship: BFO:0000051 http://identifiers.org/ncbigene/78748 ! has part Rassf10 (Mmus) property_value: CLM:0010004 "0.6" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIAAAFDQkdDMFUzMFZWOUpQUjYwVEpVAAIBNTI3OSBORk9MIE5OXzIAAAQBAQKBrMaOgZYVIAOEak39hFgYTQAFAgFEYngyAAABUmFzc2YxMAAABgEBAkNCR0MwVTMwVlY5SlBSNjBUSlUAA34AAAAEAAAIRzRJNEdGSlhKQjlBVFozUFRYMQAJTFZEQkpBVzhCSTVZU1MxUVVCRwAKAAsBbm9uZQACbm9uZQADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAABSzlKTjIzUDI0S1FDR0s5VTc1QQACSFNZWlBaVzE2NjlVODIxQldZUAADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIAAAFDQkdDMFUzMFZWOUpQUjYwVEpVAAIBNTI3OSBORk9MIE5OXzIAAAQBAAKEUL8fg4IJfwOEoBqHhMQ92QQyTlFUSUU3VEFNUDhQUUFITzRQAAWBr6ZKgemsDoGggUeAktXoBgAHAAAFAgFEYngyAAABUmFzc2YxMAAABgEBAkNCR0MwVTMwVlY5SlBSNjBUSlUAA34AAAAEAAAIVkZPRllQRlFHUktVRFFVWjNGRgAJTFZEQkpBVzhCSTVZU1MxUVVCRwAKAAsBVExPS1dDTDk1UlUwM0Q5UEVURwACNzNHVlREWERFR0UyN00yWEpNVAADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAACAwA%3D" xsd:string {name="markers in reference data on Allen Brain Cell Atlas"} property_value: STATO:0000416 "0.7692308" xsd:float property_value: STATO:0000663 "0.7281553" xsd:float [Term] id: CLM:5022250 name: Rgs16,Rhbdl2 (Yao - within subclass). xref: https://doi.org/10.1038/s41586-023-06812-z is_a: SO:0001260 ! 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sequence_collection relationship: BFO:0000051 http://identifiers.org/ncbigene/65969 ! has part Cubn (Mmus) property_value: CLM:0010004 "0.9" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#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%2BDggl%2FA4SgGoeExD3ZBDJOUVRJRTdUQU1QOFBRQUhPNFAABYGvpkqB6awOgaCBR4CS1egGAAcAAAUBAUN1Ym4gNAAABgEBAkNCR0MwVTMwVlY5SlBSNjBUSlUAA34AAAAEAAAIVkZPRllQRlFHUktVRFFVWjNGRgAJTFZEQkpBVzhCSTVZU1MxUVVCRwAKAAsBVExPS1dDTDk1UlUwM0Q5UEVURwACNzNHVlREWERFR0UyN00yWEpNVAADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAACAwA%3D" xsd:string {name="markers in reference data on Allen Brain Cell Atlas"} property_value: STATO:0000416 "0.9" xsd:float property_value: STATO:0000663 "0.9" xsd:float [Term] id: CLM:5022282 name: C1qa,Tmem119 (Yao - within subclass). xref: https://doi.org/10.1038/s41586-023-06812-z is_a: SO:0001260 ! sequence_collection relationship: BFO:0000051 http://identifiers.org/ncbigene/12259 ! has part C1qa (Mmus) relationship: BFO:0000051 http://identifiers.org/ncbigene/231633 ! has part Tmem119 (Mmus) property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#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%2FH4OCCX8DhKAah4TEPdkEMk5RVElFN1RBTVA4UFFBSE80UAAFga%2BmSoHprA6BoIFHgJLV6AYABwAABQIBQzFxYQAAAVRtZW0xMTkAAAYBAQJRWTVTOEtNTzVITEpVRjBQMDBLAAN%2BAAAABAAACFZGT0ZZUEZRR1JLVURRVVozRkYACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAVRMT0tXQ0w5NVJVMDNEOVBFVEcAAjczR1ZURFhERUdFMjdNMlhKTVQAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAgMA" xsd:string {name="markers in reference data on Allen Brain Cell Atlas"} [Term] id: CLM:5022283 name: Mrc1,Pf4 (Yao - within subclass). xref: https://doi.org/10.1038/s41586-023-06812-z is_a: SO:0001260 ! sequence_collection relationship: BFO:0000051 http://identifiers.org/ncbigene/17533 ! has part Mrc1 (Mmus) relationship: BFO:0000051 http://identifiers.org/ncbigene/56744 ! has part Pf4 (Mmus) property_value: CLM:0010004 "0.1" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIAAAFDQkdDMFUzMFZWOUpQUjYwVEpVAAIBNTMxMyBCQU0gTk5fMQAABAEBAoGsxo6BlhUgA4RqTf2EWBhNAAUCAU1yYzEAAAFQZjQAAAYBAQJDQkdDMFUzMFZWOUpQUjYwVEpVAAN%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%3D%3D" xsd:string {name="markers in reference data on Allen Brain Cell Atlas"} property_value: STATO:0000416 "0.2" xsd:float property_value: STATO:0000663 "0.16666667" xsd:float [Term] id: CLM:5022284 name: Fos (Yao - within subclass). xref: https://doi.org/10.1038/s41586-023-06812-z is_a: SO:0001260 ! sequence_collection relationship: BFO:0000051 http://identifiers.org/ncbigene/14281 ! has part Fos (Mmus) property_value: CLM:0010004 "0.8" xsd:string property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#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%2BDggl%2FA4SgGoeExD3ZBDJOUVRJRTdUQU1QOFBRQUhPNFAABYGvpkqB6awOgaCBR4CS1egGAAcAAAUBAUZvcwAABgEBAkNCR0MwVTMwVlY5SlBSNjBUSlUAA34AAAAEAAAIVkZPRllQRlFHUktVRFFVWjNGRgAJTFZEQkpBVzhCSTVZU1MxUVVCRwAKAAsBVExPS1dDTDk1UlUwM0Q5UEVURwACNzNHVlREWERFR0UyN00yWEpNVAADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAACAwA%3D" xsd:string {name="markers in reference data on Allen Brain Cell Atlas"} property_value: STATO:0000416 "0.8888889" xsd:float property_value: STATO:0000663 "0.8695652" xsd:float [Term] id: CLM:5024421 name: Gpr17, Bmp4, Neu4, Fyn (CAS evidence). is_a: SO:0001260 ! sequence_collection relationship: BFO:0000051 http://identifiers.org/ncbigene/12159 ! has part Bmp4 (Mmus) relationship: BFO:0000051 http://identifiers.org/ncbigene/14360 ! has part Fyn (Mmus) relationship: BFO:0000051 http://identifiers.org/ncbigene/241159 ! has part Neu4 (Mmus) relationship: BFO:0000051 http://identifiers.org/ncbigene/574402 ! has part Gpr17 (Mmus) property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIBMTE4MSBDT1AgTk5fMQAAAUNCR0MwVTMwVlY5SlBSNjBUSlUAAgAABAEBAoGsxo6BlhUgA4RqTf2EWBhNAAUEAUdwcjE3AAABQm1wNAAAAU5ldTQAAAFGeW4AAAYBAQIxNUJLNDdEQ0lPRjFTTExVVzlQAAN%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%3D%3D" xsd:string {name="markers in reference data on Allen Brain Cell Atlas"} [Term] id: CLM:5024422 name: Tcf7l2, Klk6, Cemip2, Casr (CAS evidence). is_a: SO:0001260 ! sequence_collection relationship: BFO:0000051 http://identifiers.org/ncbigene/12374 ! has part Casr (Mmus) relationship: BFO:0000051 http://identifiers.org/ncbigene/19144 ! has part Klk6 (Mmus) relationship: BFO:0000051 http://identifiers.org/ncbigene/21416 ! has part Tcf7l2 (Mmus) relationship: BFO:0000051 http://identifiers.org/ncbigene/83921 ! has part Cemip2 (Mmus) property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#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%3D" xsd:string {name="markers in reference data on Allen Brain Cell Atlas"} [Term] id: CLM:5024423 name: Ctps, Cldn11 (CAS evidence). is_a: SO:0001260 ! sequence_collection relationship: BFO:0000051 http://identifiers.org/ncbigene/18417 ! has part Cldn11 (Mmus) relationship: BFO:0000051 http://identifiers.org/ncbigene/51797 ! has part Ctps (Mmus) property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#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%2BDggl%2FA4SgGoeExD3ZBDJOUVRJRTdUQU1QOFBRQUhPNFAABYGvpkqB6awOgaCBR4CS1egGAAcAAAUCAUN0cHMAAAFDbGRuMTEAAAYBAQIxNUJLNDdEQ0lPRjFTTExVVzlQAAN%2BAAAABAAACFZGT0ZZUEZRR1JLVURRVVozRkYACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAVRMT0tXQ0w5NVJVMDNEOVBFVEcAAjczR1ZURFhERUdFMjdNMlhKTVQAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAgMA" xsd:string {name="markers in reference data on Allen Brain Cell Atlas"} [Term] id: CLM:5024424 name: Klk6 (CAS evidence). is_a: SO:0001260 ! sequence_collection relationship: BFO:0000051 http://identifiers.org/ncbigene/19144 ! has part Klk6 (Mmus) property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIBMTE4NCBNT0wgTk5fNAAAAUNCR0MwVTMwVlY5SlBSNjBUSlUAAgAABAEBAoGsxo6BlhUgA4RqTf2EWBhNAAUBAUtsazYAAAYBAQIxNUJLNDdEQ0lPRjFTTExVVzlQAAN%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%3D%3D" xsd:string {name="markers in reference data on Allen Brain Cell Atlas"} [Term] id: CLM:5029176 name: Crx, Gngt1, Tph1, Asmt, Gngt2 (CAS evidence). is_a: SO:0001260 ! sequence_collection relationship: BFO:0000051 http://identifiers.org/ncbigene/107626 ! has part Asmt (Mmus) relationship: BFO:0000051 http://identifiers.org/ncbigene/12951 ! has part Crx (Mmus) relationship: BFO:0000051 http://identifiers.org/ncbigene/14699 ! has part Gngt1 (Mmus) relationship: BFO:0000051 http://identifiers.org/ncbigene/14710 ! has part Gngt2 (Mmus) relationship: BFO:0000051 http://identifiers.org/ncbigene/21990 ! has part Tph1 (Mmus) property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#AQIBQVA4Sk5ONUxZQUJHVk1HS1kxQgACUTFOQ1dXUEc2RlowRE5JWEpCUQADBAFGUzAwRFhWMFQ5UjFYOUZKNFFFAAIBMjUgUGluZWFsIEdsdXQAAAFRWTVTOEtNTzVITEpVRjBQMDBLAAIAAAExNUJLNDdEQ0lPRjFTTExVVzlQAAIAAAFDQkdDMFUzMFZWOUpQUjYwVEpVAAIAAAQBAQKBrMaOgZYVIAOEak39hFgYTQAFBQFDcngAAAFHbmd0MQAAAVRwaDEAAAFBc210AAABR25ndDIAAAYBAQJGUzAwRFhWMFQ5UjFYOUZKNFFFAAN%2BAAAABAAACEc0STRHRkpYSkI5QVRaM1BUWDEACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAW5vbmUAAm5vbmUAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAUs5Sk4yM1AyNEtRQ0dLOVU3NUEAAkhTWVpQWlcxNjY5VTgyMUJXWVAAAwQBRlMwMERYVjBUOVIxWDlGSjRRRQACATI1IFBpbmVhbCBHbHV0AAABUVk1UzhLTU81SExKVUYwUDAwSwACAAABMTVCSzQ3RENJT0YxU0xMVVc5UAACAAABQ0JHQzBVMzBWVjlKUFI2MFRKVQACAAAEAQAChFC%2FH4OCCX8DhKAah4TEPdkEMk5RVElFN1RBTVA4UFFBSE80UAAFga%2BmSoHprA6BoIFHgJLV6AYABwAABQUBQ3J4AAABR25ndDEAAAFUcGgxAAABQXNtdAAAAUduZ3QyAAAGAQECRlMwMERYVjBUOVIxWDlGSjRRRQADfgAAAAQAAAhWRk9GWVBGUUdSS1VEUVVaM0ZGAAlMVkRCSkFXOEJJNVlTUzFRVUJHAAoACwFUTE9LV0NMOTVSVTAzRDlQRVRHAAI3M0dWVERYREVHRTI3TTJYSk1UAAMBBAEAAiMwMDAwMDAAA8gBAAUBAQIjMDAwMDAwAAPIAQAAAAIDAA%3D%3D" xsd:string {name="markers in reference data on Allen Brain Cell Atlas"} [Term] id: CLM:5029833 name: Sspo (CAS evidence). is_a: SO:0001260 ! sequence_collection relationship: BFO:0000051 http://identifiers.org/ncbigene/243369 ! has part Sspo (Mmus) property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#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%2BDggl%2FA4SgGoeExD3ZBDJOUVRJRTdUQU1QOFBRQUhPNFAABYGvpkqB6awOgaCBR4CS1egGAAcAAAUBAVNzcG8AAAYBAQJRWTVTOEtNTzVITEpVRjBQMDBLAAN%2BAAAABAAACFZGT0ZZUEZRR1JLVURRVVozRkYACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAVRMT0tXQ0w5NVJVMDNEOVBFVEcAAjczR1ZURFhERUdFMjdNMlhKTVQAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAgMA" xsd:string {name="markers in reference data on Allen Brain Cell Atlas"} [Term] id: CLM:5050484 name: LAMP5, CXCL14 (CAS evidence). is_a: SO:0001260 ! sequence_collection relationship: BFO:0000051 http://identifiers.org/ncbigene/24141 ! has part LAMP5 relationship: BFO:0000051 http://identifiers.org/ncbigene/9547 ! has part CXCL14 property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#AQQBTlhKOU5aQVFBNU1FSFFOT1dKUQACVEdCUTJGRVYyN04wQ1BMS1ZBWgADBQFFM0hHQllIUkM5OEdBNkZXOUY2AAIAAAEzWEJPRkJSMzAyRVlDMFVRRDUxAAIAAAFTUTZXSk8wR05VSkdGVThMSFZWAAIAAAFISzE0TzFBU0FOUFlIT05GTExRAAIBTEFNUDUtQ1hDTDE0IEdBQkEAAAE2RVdCU0VKNFlGVkdLSTJBUEJMAAIAAAQBAAKEykWZhH5WhgOFDHL%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%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%2BA4Re3WaD6nvJAAUCAUxBTVA1AAABQ1hDTDE0AAAGAQECSEsxNE8xQVNBTlBZSE9ORkxMUQADfgAAAAQAAAhGVExBVU9WNlNMQjA3MVNWTlU5AAlQT1oySENQQlQ2MERTREo4VUE3AAoACwFub25lAAJub25lAAMBBAEAAiMwMDAwMDAAA8gBAAUBAQIjMDAwMDAwAAPIAQAAAAIIAA%3D%3D" xsd:string {name="markers in reference data on Allen Brain Cell Atlas"} [Term] id: CLM:5050485 name: LAMP5, LHX6 (CAS evidence). is_a: SO:0001260 ! sequence_collection relationship: BFO:0000051 http://identifiers.org/ncbigene/24141 ! has part LAMP5 relationship: BFO:0000051 http://identifiers.org/ncbigene/26468 ! has part LHX6 property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#AQQBTlhKOU5aQVFBNU1FSFFOT1dKUQACVEdCUTJGRVYyN04wQ1BMS1ZBWgADBQFFM0hHQllIUkM5OEdBNkZXOUY2AAIAAAEzWEJPRkJSMzAyRVlDMFVRRDUxAAIAAAFTUTZXSk8wR05VSkdGVThMSFZWAAIAAAFISzE0TzFBU0FOUFlIT05GTExRAAIBTEFNUDUtTEhYNiBHQUJBAAABNkVXQlNFSjRZRlZHS0kyQVBCTAACAAAEAQAChMpFmYR%2BVoYDhQxy%2FoU8XEUEV01QOE5NSjVEOFhPMUFPSTFMOQAFg2xvMYI24kGDwAnEgzgCUgAFAgFMQU1QNQAAAUxIWDYAAAYBAQJISzE0TzFBU0FOUFlIT05GTExRAAN%2BAAAABAAACElBNlk2U043UVpTSUVKMEZaMFUACVBPWjJIQ1BCVDYwRFNESjhVQTcACgALATc0MTZCNVhKRFNZMEhERjkzUk8AAkNSRUhSQ0syWVhSV0pLMkowQUwAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAVZNNEU2SjlEUFlZRDdFMEJITkIAAktHWkxBV0lQQ1I0Vzk4RjVMRDYAAwUBRTNIR0JZSFJDOThHQTZGVzlGNgACAAABM1hCT0ZCUjMwMkVZQzBVUUQ1MQACAAABU1E2V0pPMEdOVUpHRlU4TEhWVgACAAABSEsxNE8xQVNBTlBZSE9ORkxMUQACAUxBTVA1LUxIWDYgR0FCQQAAATZFV0JTRUo0WUZWR0tJMkFQQkwAAgAABAEAAoX%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%2Bp7yQAFAgFMQU1QNQAAAUxIWDYAAAYBAQJISzE0TzFBU0FOUFlIT05GTExRAAN%2BAAAABAAACEZUTEFVT1Y2U0xCMDcxU1ZOVTkACVBPWjJIQ1BCVDYwRFNESjhVQTcACgALAW5vbmUAAm5vbmUAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAggA" xsd:string {name="markers in reference data on Allen Brain Cell Atlas"} [Term] id: CLM:5050493 name: GAD1, GAD2, FOXP2, MEIS2, NPAS1 (CAS evidence). is_a: SO:0001260 ! sequence_collection relationship: BFO:0000051 http://identifiers.org/ncbigene/2571 ! has part GAD1 relationship: BFO:0000051 http://identifiers.org/ncbigene/2572 ! has part GAD2 relationship: BFO:0000051 http://identifiers.org/ncbigene/4212 ! has part MEIS2 relationship: BFO:0000051 http://identifiers.org/ncbigene/4861 ! has part NPAS1 relationship: BFO:0000051 http://identifiers.org/ncbigene/93986 ! has part FOXP2 property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#AQQBTlhKOU5aQVFBNU1FSFFOT1dKUQACVEdCUTJGRVYyN04wQ1BMS1ZBWgADBQFFM0hHQllIUkM5OEdBNkZXOUY2AAIAAAEzWEJPRkJSMzAyRVlDMFVRRDUxAAIAAAFTUTZXSk8wR05VSkdGVThMSFZWAAIAAAFISzE0TzFBU0FOUFlIT05GTExRAAIBR1BlIE1FSVMyLVNPWDYgR0FCQQAAATZFV0JTRUo0WUZWR0tJMkFQQkwAAgAABAEAAoTKRZmEflaGA4UMcv6FPFxFBFdNUDhOTUo1RDhYTzFBT0kxTDkABYNsbzGCNuJBg8AJxIM4AlIABQUBR0FEMQAAAUdBRDIAAAFGT1hQMgAAAU1FSVMyAAABTlBBUzEAAAYBAQJISzE0TzFBU0FOUFlIT05GTExRAAN%2BAAAABAAACElBNlk2U043UVpTSUVKMEZaMFUACVBPWjJIQ1BCVDYwRFNESjhVQTcACgALATc0MTZCNVhKRFNZMEhERjkzUk8AAkNSRUhSQ0syWVhSV0pLMkowQUwAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAVZNNEU2SjlEUFlZRDdFMEJITkIAAktHWkxBV0lQQ1I0Vzk4RjVMRDYAAwUBRTNIR0JZSFJDOThHQTZGVzlGNgACAAABM1hCT0ZCUjMwMkVZQzBVUUQ1MQACAAABU1E2V0pPMEdOVUpHRlU4TEhWVgACAAABSEsxNE8xQVNBTlBZSE9ORkxMUQACAUdQZSBNRUlTMi1TT1g2IEdBQkEAAAE2RVdCU0VKNFlGVkdLSTJBUEJMAAIAAAQBAAKF%2FlmIhY7XHwOGCqZOhfScqgRXTVA4Tk1KNUQ4WE8xQU9JMUw5AAWEFMQWg4zFUoRiab%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%2BAAAABAAACEZUTEFVT1Y2U0xCMDcxU1ZOVTkACVBPWjJIQ1BCVDYwRFNESjhVQTcACgALAW5vbmUAAm5vbmUAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAggA" xsd:string {name="markers in reference data on Allen Brain Cell Atlas"} [Term] id: CLM:5050494 name: SOX6, KCNA1 (CAS evidence). is_a: SO:0001260 ! sequence_collection relationship: BFO:0000051 http://identifiers.org/ncbigene/3736 ! has part KCNA1 relationship: BFO:0000051 http://identifiers.org/ncbigene/55553 ! has part SOX6 property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#AQQBTlhKOU5aQVFBNU1FSFFOT1dKUQACVEdCUTJGRVYyN04wQ1BMS1ZBWgADBQFFM0hHQllIUkM5OEdBNkZXOUY2AAIAAAEzWEJPRkJSMzAyRVlDMFVRRDUxAAIAAAFTUTZXSk8wR05VSkdGVThMSFZWAAIAAAFISzE0TzFBU0FOUFlIT05GTExRAAIBR1BlIFNPWDYtQ1RYTkQxIEdBQkEAAAE2RVdCU0VKNFlGVkdLSTJBUEJMAAIAAAQBAAKEykWZhH5WhgOFDHL%2BhTxcRQRXTVA4Tk1KNUQ4WE8xQU9JMUw5AAWDbG8xgjbiQYPACcSDOAJSAAUCAVNPWDYAAAFLQ05BMQAABgEBAkhLMTRPMUFTQU5QWUhPTkZMTFEAA34AAAAEAAAISUE2WTZTTjdRWlNJRUowRlowVQAJUE9aMkhDUEJUNjBEU0RKOFVBNwAKAAsBNzQxNkI1WEpEU1kwSERGOTNSTwACQ1JFSFJDSzJZWFJXSksySjBBTAADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAABVk00RTZKOURQWVlEN0UwQkhOQgACS0daTEFXSVBDUjRXOThGNUxENgADBQFFM0hHQllIUkM5OEdBNkZXOUY2AAIAAAEzWEJPRkJSMzAyRVlDMFVRRDUxAAIAAAFTUTZXSk8wR05VSkdGVThMSFZWAAIAAAFISzE0TzFBU0FOUFlIT05GTExRAAIBR1BlIFNPWDYtQ1RYTkQxIEdBQkEAAAE2RVdCU0VKNFlGVkdLSTJBUEJMAAIAAAQBAAKF%2FlmIhY7XHwOGCqZOhfScqgRXTVA4Tk1KNUQ4WE8xQU9JMUw5AAWEFMQWg4zFUoRiab%2BEtOdLBgAHAAAFAgFTT1g2AAABS0NOQTEAAAYBAQJISzE0TzFBU0FOUFlIT05GTExRAAN%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%2BA4Re3WaD6nvJAAUCAVNPWDYAAAFLQ05BMQAABgEBAkhLMTRPMUFTQU5QWUhPTkZMTFEAA34AAAAEAAAIRlRMQVVPVjZTTEIwNzFTVk5VOQAJUE9aMkhDUEJUNjBEU0RKOFVBNwAKAAsBbm9uZQACbm9uZQADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAACCAA%3D" xsd:string {name="markers in reference data on Allen Brain Cell Atlas"} [Term] id: CLM:5050495 name: Pvalb (CAS evidence). is_a: SO:0001260 ! sequence_collection relationship: BFO:0000051 http://identifiers.org/ncbigene/5816 ! has part PVALB property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#AQQBTlhKOU5aQVFBNU1FSFFOT1dKUQACVEdCUTJGRVYyN04wQ1BMS1ZBWgADBQFFM0hHQllIUkM5OEdBNkZXOUY2AAIAAAEzWEJPRkJSMzAyRVlDMFVRRDUxAAIAAAFTUTZXSk8wR05VSkdGVThMSFZWAAIAAAFISzE0TzFBU0FOUFlIT05GTExRAAIBR1BpIENvcmUAAAE2RVdCU0VKNFlGVkdLSTJBUEJMAAIAAAQBAAKEykWZhH5WhgOFDHL%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%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%2BA4Re3WaD6nvJAAUBAVB2YWxiAAAGAQECSEsxNE8xQVNBTlBZSE9ORkxMUQADfgAAAAQAAAhGVExBVU9WNlNMQjA3MVNWTlU5AAlQT1oySENQQlQ2MERTREo4VUE3AAoACwFub25lAAJub25lAAMBBAEAAiMwMDAwMDAAA8gBAAUBAQIjMDAwMDAwAAPIAQAAAAIIAA%3D%3D" xsd:string {name="markers in reference data on Allen Brain Cell Atlas"} [Term] id: CLM:5050496 name: Sst, Tbr1, Slc17a6 (CAS evidence). is_a: SO:0001260 ! sequence_collection relationship: BFO:0000051 http://identifiers.org/ncbigene/10716 ! has part TBR1 relationship: BFO:0000051 http://identifiers.org/ncbigene/57084 ! has part SLC17A6 relationship: BFO:0000051 http://identifiers.org/ncbigene/6752 ! has part SSTR2 property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#AQQBTlhKOU5aQVFBNU1FSFFOT1dKUQACVEdCUTJGRVYyN04wQ1BMS1ZBWgADBQFFM0hHQllIUkM5OEdBNkZXOUY2AAIAAAEzWEJPRkJSMzAyRVlDMFVRRDUxAAIBQ04gR0FCQS1HbHV0AAABU1E2V0pPMEdOVUpHRlU4TEhWVgACAAABSEsxNE8xQVNBTlBZSE9ORkxMUQACAAABNkVXQlNFSjRZRlZHS0kyQVBCTAACAAAEAQAChMpFmYR%2BVoYDhQxy%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%2FhLTnSwYABwAABQMBU3N0AAABVGJyMQAAAVNsYzE3YTYAAAYBAQIzWEJPRkJSMzAyRVlDMFVRRDUxAAN%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%2Bp7yQAFAwFTc3QAAAFUYnIxAAABU2xjMTdhNgAABgEBAjNYQk9GQlIzMDJFWUMwVVFENTEAA34AAAAEAAAIRlRMQVVPVjZTTEIwNzFTVk5VOQAJUE9aMkhDUEJUNjBEU0RKOFVBNwAKAAsBbm9uZQACbm9uZQADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAACCAA%3D" xsd:string {name="markers in reference data on Allen Brain Cell Atlas"} [Term] id: CLM:5050504 name: DRD1, CPNE4 (CAS evidence). is_a: SO:0001260 ! sequence_collection relationship: BFO:0000051 http://identifiers.org/ncbigene/131034 ! has part CPNE4 relationship: BFO:0000051 http://identifiers.org/ncbigene/1812 ! has part DRD1 property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#AQQBTlhKOU5aQVFBNU1FSFFOT1dKUQACVEdCUTJGRVYyN04wQ1BMS1ZBWgADBQFFM0hHQllIUkM5OEdBNkZXOUY2AAIAAAEzWEJPRkJSMzAyRVlDMFVRRDUxAAIAAAFTUTZXSk8wR05VSkdGVThMSFZWAAIAAAFISzE0TzFBU0FOUFlIT05GTExRAAIBT1QgRDEgSUNqAAABNkVXQlNFSjRZRlZHS0kyQVBCTAACAAAEAQAChMpFmYR%2BVoYDhQxy%2FoU8XEUEV01QOE5NSjVEOFhPMUFPSTFMOQAFg2xvMYI24kGDwAnEgzgCUgAFAgFEUkQxAAABQ1BORTQAAAYBAQJISzE0TzFBU0FOUFlIT05GTExRAAN%2BAAAABAAACElBNlk2U043UVpTSUVKMEZaMFUACVBPWjJIQ1BCVDYwRFNESjhVQTcACgALATc0MTZCNVhKRFNZMEhERjkzUk8AAkNSRUhSQ0syWVhSV0pLMkowQUwAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAVZNNEU2SjlEUFlZRDdFMEJITkIAAktHWkxBV0lQQ1I0Vzk4RjVMRDYAAwUBRTNIR0JZSFJDOThHQTZGVzlGNgACAAABM1hCT0ZCUjMwMkVZQzBVUUQ1MQACAAABU1E2V0pPMEdOVUpHRlU4TEhWVgACAAABSEsxNE8xQVNBTlBZSE9ORkxMUQACAU9UIEQxIElDagAAATZFV0JTRUo0WUZWR0tJMkFQQkwAAgAABAEAAoX%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%2Bp7yQAFAgFEUkQxAAABQ1BORTQAAAYBAQJISzE0TzFBU0FOUFlIT05GTExRAAN%2BAAAABAAACEZUTEFVT1Y2U0xCMDcxU1ZOVTkACVBPWjJIQ1BCVDYwRFNESjhVQTcACgALAW5vbmUAAm5vbmUAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAggA" xsd:string {name="markers in reference data on Allen Brain Cell Atlas"} [Term] id: CLM:5050509 name: TH, CALB1, SLC6A3, NR4A2, BNC2 (CAS evidence). is_a: SO:0001260 ! sequence_collection relationship: BFO:0000051 http://identifiers.org/ncbigene/4929 ! has part NR4A2 relationship: BFO:0000051 http://identifiers.org/ncbigene/54796 ! has part BNC2 relationship: BFO:0000051 http://identifiers.org/ncbigene/6531 ! has part SLC6A3 relationship: BFO:0000051 http://identifiers.org/ncbigene/7054 ! has part TH relationship: BFO:0000051 http://identifiers.org/ncbigene/793 ! has part CALB1 property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#AQQBTlhKOU5aQVFBNU1FSFFOT1dKUQACVEdCUTJGRVYyN04wQ1BMS1ZBWgADBQFFM0hHQllIUkM5OEdBNkZXOUY2AAIAAAEzWEJPRkJSMzAyRVlDMFVRRDUxAAIAAAFTUTZXSk8wR05VSkdGVThMSFZWAAIAAAFISzE0TzFBU0FOUFlIT05GTExRAAIBU04tVlRSIENBTEIxIERvcGEAAAE2RVdCU0VKNFlGVkdLSTJBUEJMAAIAAAQBAAKEykWZhH5WhgOFDHL%2BhTxcRQRXTVA4Tk1KNUQ4WE8xQU9JMUw5AAWDbG8xgjbiQYPACcSDOAJSAAUFAVRIAAABQ0FMQjEAAAFTTEM2QTMAAAFOUjRBMgAAAUJOQzIAAAYBAQJISzE0TzFBU0FOUFlIT05GTExRAAN%2BAAAABAAACElBNlk2U043UVpTSUVKMEZaMFUACVBPWjJIQ1BCVDYwRFNESjhVQTcACgALATc0MTZCNVhKRFNZMEhERjkzUk8AAkNSRUhSQ0syWVhSV0pLMkowQUwAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAVZNNEU2SjlEUFlZRDdFMEJITkIAAktHWkxBV0lQQ1I0Vzk4RjVMRDYAAwUBRTNIR0JZSFJDOThHQTZGVzlGNgACAAABM1hCT0ZCUjMwMkVZQzBVUUQ1MQACAAABU1E2V0pPMEdOVUpHRlU4TEhWVgACAAABSEsxNE8xQVNBTlBZSE9ORkxMUQACAVNOLVZUUiBDQUxCMSBEb3BhAAABNkVXQlNFSjRZRlZHS0kyQVBCTAACAAAEAQAChf5ZiIWO1x8DhgqmToX0nKoEV01QOE5NSjVEOFhPMUFPSTFMOQAFhBTEFoOMxVKEYmm%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%2BA4Re3WaD6nvJAAUFAVRIAAABQ0FMQjEAAAFTTEM2QTMAAAFOUjRBMgAAAUJOQzIAAAYBAQJISzE0TzFBU0FOUFlIT05GTExRAAN%2BAAAABAAACEZUTEFVT1Y2U0xCMDcxU1ZOVTkACVBPWjJIQ1BCVDYwRFNESjhVQTcACgALAW5vbmUAAm5vbmUAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAggA" xsd:string {name="markers in reference data on Allen Brain Cell Atlas"} [Term] id: CLM:5050511 name: TH, GAD2 (CAS evidence). is_a: SO:0001260 ! sequence_collection relationship: BFO:0000051 http://identifiers.org/ncbigene/2572 ! has part GAD2 relationship: BFO:0000051 http://identifiers.org/ncbigene/7054 ! has part TH property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#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%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%3D%3D" xsd:string {name="markers in reference data on Allen Brain Cell Atlas"} [Term] id: CLM:5050512 name: PAX5, BCL11B, POU6F2 (CAS evidence). is_a: SO:0001260 ! sequence_collection relationship: BFO:0000051 http://identifiers.org/ncbigene/11281 ! has part POU6F2 relationship: BFO:0000051 http://identifiers.org/ncbigene/5079 ! has part PAX5 relationship: BFO:0000051 http://identifiers.org/ncbigene/64919 ! has part BCL11B property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#AQQBTlhKOU5aQVFBNU1FSFFOT1dKUQACVEdCUTJGRVYyN04wQ1BMS1ZBWgADBQFFM0hHQllIUkM5OEdBNkZXOUY2AAIAAAEzWEJPRkJSMzAyRVlDMFVRRDUxAAIAAAFTUTZXSk8wR05VSkdGVThMSFZWAAIAAAFISzE0TzFBU0FOUFlIT05GTExRAAIBU04gR0FUQTMtUEFYOCBHQUJBAAABNkVXQlNFSjRZRlZHS0kyQVBCTAACAAAEAQAChMpFmYR%2BVoYDhQxy%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%2FlmIhY7XHwOGCqZOhfScqgRXTVA4Tk1KNUQ4WE8xQU9JMUw5AAWEFMQWg4zFUoRiab%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%2Bp7yQAFAwFQQVg1AAABQkNMMTFCAAABUE9VNkYyAAAGAQECSEsxNE8xQVNBTlBZSE9ORkxMUQADfgAAAAQAAAhGVExBVU9WNlNMQjA3MVNWTlU5AAlQT1oySENQQlQ2MERTREo4VUE3AAoACwFub25lAAJub25lAAMBBAEAAiMwMDAwMDAAA8gBAAUBAQIjMDAwMDAwAAPIAQAAAAIIAA%3D%3D" xsd:string {name="markers in reference data on Allen Brain Cell Atlas"} [Term] id: CLM:5050513 name: SIX3, FOXP1 (CAS evidence). is_a: SO:0001260 ! sequence_collection relationship: BFO:0000051 http://identifiers.org/ncbigene/27086 ! has part FOXP1 relationship: BFO:0000051 http://identifiers.org/ncbigene/6496 ! has part SIX3 property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#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%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%3D%3D" xsd:string {name="markers in reference data on Allen Brain Cell Atlas"} [Term] id: CLM:5050515 name: TH, SOX6 (CAS evidence). is_a: SO:0001260 ! sequence_collection relationship: BFO:0000051 http://identifiers.org/ncbigene/55553 ! has part SOX6 relationship: BFO:0000051 http://identifiers.org/ncbigene/7054 ! has part TH property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#AQQBTlhKOU5aQVFBNU1FSFFOT1dKUQACVEdCUTJGRVYyN04wQ1BMS1ZBWgADBQFFM0hHQllIUkM5OEdBNkZXOUY2AAIAAAEzWEJPRkJSMzAyRVlDMFVRRDUxAAIAAAFTUTZXSk8wR05VSkdGVThMSFZWAAIAAAFISzE0TzFBU0FOUFlIT05GTExRAAIBU04gU09YNiBEb3BhAAABNkVXQlNFSjRZRlZHS0kyQVBCTAACAAAEAQAChMpFmYR%2BVoYDhQxy%2FoU8XEUEV01QOE5NSjVEOFhPMUFPSTFMOQAFg2xvMYI24kGDwAnEgzgCUgAFAgFUSAAAAVNPWDYAAAYBAQJISzE0TzFBU0FOUFlIT05GTExRAAN%2BAAAABAAACElBNlk2U043UVpTSUVKMEZaMFUACVBPWjJIQ1BCVDYwRFNESjhVQTcACgALATc0MTZCNVhKRFNZMEhERjkzUk8AAkNSRUhSQ0syWVhSV0pLMkowQUwAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAVZNNEU2SjlEUFlZRDdFMEJITkIAAktHWkxBV0lQQ1I0Vzk4RjVMRDYAAwUBRTNIR0JZSFJDOThHQTZGVzlGNgACAAABM1hCT0ZCUjMwMkVZQzBVUUQ1MQACAAABU1E2V0pPMEdOVUpHRlU4TEhWVgACAAABSEsxNE8xQVNBTlBZSE9ORkxMUQACAVNOIFNPWDYgRG9wYQAAATZFV0JTRUo0WUZWR0tJMkFQQkwAAgAABAEAAoX%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%2Bp7yQAFAgFUSAAAAVNPWDYAAAYBAQJISzE0TzFBU0FOUFlIT05GTExRAAN%2BAAAABAAACEZUTEFVT1Y2U0xCMDcxU1ZOVTkACVBPWjJIQ1BCVDYwRFNESjhVQTcACgALAW5vbmUAAm5vbmUAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAggA" xsd:string {name="markers in reference data on Allen Brain Cell Atlas"} [Term] id: CLM:5050520 name: ST18, PTHLH, COL19A1 (CAS evidence). is_a: SO:0001260 ! sequence_collection relationship: BFO:0000051 http://identifiers.org/ncbigene/1310 ! has part COL19A1 relationship: BFO:0000051 http://identifiers.org/ncbigene/5744 ! has part PTHLH relationship: BFO:0000051 http://identifiers.org/ncbigene/9705 ! has part ST18 property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#AQQBTlhKOU5aQVFBNU1FSFFOT1dKUQACVEdCUTJGRVYyN04wQ1BMS1ZBWgADBQFFM0hHQllIUkM5OEdBNkZXOUY2AAIAAAEzWEJPRkJSMzAyRVlDMFVRRDUxAAIAAAFTUTZXSk8wR05VSkdGVThMSFZWAAIAAAFISzE0TzFBU0FOUFlIT05GTExRAAIBU1RSIEZTIFBUSExILVBWQUxCIEdBQkEAAAE2RVdCU0VKNFlGVkdLSTJBUEJMAAIAAAQBAAKEykWZhH5WhgOFDHL%2BhTxcRQRXTVA4Tk1KNUQ4WE8xQU9JMUw5AAWDbG8xgjbiQYPACcSDOAJSAAUDAVNUMTgAAAFQVEhMSAAAAUNPTDE5QTEAAAYBAQJISzE0TzFBU0FOUFlIT05GTExRAAN%2BAAAABAAACElBNlk2U043UVpTSUVKMEZaMFUACVBPWjJIQ1BCVDYwRFNESjhVQTcACgALATc0MTZCNVhKRFNZMEhERjkzUk8AAkNSRUhSQ0syWVhSV0pLMkowQUwAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAVZNNEU2SjlEUFlZRDdFMEJITkIAAktHWkxBV0lQQ1I0Vzk4RjVMRDYAAwUBRTNIR0JZSFJDOThHQTZGVzlGNgACAAABM1hCT0ZCUjMwMkVZQzBVUUQ1MQACAAABU1E2V0pPMEdOVUpHRlU4TEhWVgACAAABSEsxNE8xQVNBTlBZSE9ORkxMUQACAVNUUiBGUyBQVEhMSC1QVkFMQiBHQUJBAAABNkVXQlNFSjRZRlZHS0kyQVBCTAACAAAEAQAChf5ZiIWO1x8DhgqmToX0nKoEV01QOE5NSjVEOFhPMUFPSTFMOQAFhBTEFoOMxVKEYmm%2FhLTnSwYABwAABQMBU1QxOAAAAVBUSExIAAABQ09MMTlBMQAABgEBAkhLMTRPMUFTQU5QWUhPTkZMTFEAA34AAAAEAAAIOUFVVEU5UzEwS0FFQzJVWk8zMQAJUE9aMkhDUEJUNjBEU0RKOFVBNwAKAAsBWTNQMUpNMUVOQ0dXRVc4VVNUVgACQ1JFSFJDSzJZWFJXSksySjBBTAADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAABM0NQSVAyODA0U0JEWDFEWDFSVwACUzVLUVRGSENSS0hWWlZSUjVIUgADBQFFM0hHQllIUkM5OEdBNkZXOUY2AAIAAAEzWEJPRkJSMzAyRVlDMFVRRDUxAAIAAAFTUTZXSk8wR05VSkdGVThMSFZWAAIAAAFISzE0TzFBU0FOUFlIT05GTExRAAIBU1RSIEZTIFBUSExILVBWQUxCIEdBQkEAAAE2RVdCU0VKNFlGVkdLSTJBUEJMAAIAAAQBAAKF5uKGhpZBIAOHaGEyhqCThgRXTVA4Tk1KNUQ4WE8xQU9JMUw5AAWB2KHrhLYRmYTalF2FAoaGBgAHAAAFAwFTVDE4AAABUFRITEgAAAFDT0wxOUExAAAGAQECSEsxNE8xQVNBTlBZSE9ORkxMUQADfgAAAAQAAAhIWkVZWFNRT0VETkQyUTZNOTdNAAlQT1oySENQQlQ2MERTREo4VUE3AAoACwE2VDk2MjYwMTI2VFY0S0xHRFhHAAJDUkVIUkNLMllYUldKSzJKMEFMAAMBBAEAAiMwMDAwMDAAA8gBAAUBAQIjMDAwMDAwAAPIAQAAAAFFSVVBTFBZTkdaNVZVN1kyWTAyAAJRWlEyUUJNVTRUNUk0N0QxSzRGAAMFAUUzSEdCWUhSQzk4R0E2Rlc5RjYAAgAAATNYQk9GQlIzMDJFWUMwVVFENTEAAgAAAVNRNldKTzBHTlVKR0ZVOExIVlYAAgAAAUhLMTRPMUFTQU5QWUhPTkZMTFEAAgFTVFIgRlMgUFRITEgtUFZBTEIgR0FCQQAAATZFV0JTRUo0WUZWR0tJMkFQQkwAAgAABAEBAoEi0luBCLU%2BA4Re3WaD6nvJAAUDAVNUMTgAAAFQVEhMSAAAAUNPTDE5QTEAAAYBAQJISzE0TzFBU0FOUFlIT05GTExRAAN%2BAAAABAAACEZUTEFVT1Y2U0xCMDcxU1ZOVTkACVBPWjJIQ1BCVDYwRFNESjhVQTcACgALAW5vbmUAAm5vbmUAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAggA" xsd:string {name="markers in reference data on Allen Brain Cell Atlas"} [Term] id: CLM:5050523 name: NPY (CAS evidence). is_a: SO:0001260 ! sequence_collection relationship: BFO:0000051 http://identifiers.org/ncbigene/4852 ! has part NPY property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#AQQBTlhKOU5aQVFBNU1FSFFOT1dKUQACVEdCUTJGRVYyN04wQ1BMS1ZBWgADBQFFM0hHQllIUkM5OEdBNkZXOUY2AAIAAAEzWEJPRkJSMzAyRVlDMFVRRDUxAAIAAAFTUTZXSk8wR05VSkdGVThMSFZWAAIAAAFISzE0TzFBU0FOUFlIT05GTExRAAIBU1RSIFNTVC1DSE9ETCBHQUJBAAABNkVXQlNFSjRZRlZHS0kyQVBCTAACAAAEAQAChMpFmYR%2BVoYDhQxy%2FoU8XEUEV01QOE5NSjVEOFhPMUFPSTFMOQAFg2xvMYI24kGDwAnEgzgCUgAFAQFOUFkAAAYBAQJISzE0TzFBU0FOUFlIT05GTExRAAN%2BAAAABAAACElBNlk2U043UVpTSUVKMEZaMFUACVBPWjJIQ1BCVDYwRFNESjhVQTcACgALATc0MTZCNVhKRFNZMEhERjkzUk8AAkNSRUhSQ0syWVhSV0pLMkowQUwAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAVZNNEU2SjlEUFlZRDdFMEJITkIAAktHWkxBV0lQQ1I0Vzk4RjVMRDYAAwUBRTNIR0JZSFJDOThHQTZGVzlGNgACAAABM1hCT0ZCUjMwMkVZQzBVUUQ1MQACAAABU1E2V0pPMEdOVUpHRlU4TEhWVgACAAABSEsxNE8xQVNBTlBZSE9ORkxMUQACAVNUUiBTU1QtQ0hPREwgR0FCQQAAATZFV0JTRUo0WUZWR0tJMkFQQkwAAgAABAEAAoX%2BWYiFjtcfA4YKpk6F9JyqBFdNUDhOTUo1RDhYTzFBT0kxTDkABYQUxBaDjMVShGJpv4S050sGAAcAAAUBAU5QWQAABgEBAkhLMTRPMUFTQU5QWUhPTkZMTFEAA34AAAAEAAAIOUFVVEU5UzEwS0FFQzJVWk8zMQAJUE9aMkhDUEJUNjBEU0RKOFVBNwAKAAsBWTNQMUpNMUVOQ0dXRVc4VVNUVgACQ1JFSFJDSzJZWFJXSksySjBBTAADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAABM0NQSVAyODA0U0JEWDFEWDFSVwACUzVLUVRGSENSS0hWWlZSUjVIUgADBQFFM0hHQllIUkM5OEdBNkZXOUY2AAIAAAEzWEJPRkJSMzAyRVlDMFVRRDUxAAIAAAFTUTZXSk8wR05VSkdGVThMSFZWAAIAAAFISzE0TzFBU0FOUFlIT05GTExRAAIBU1RSIFNTVC1DSE9ETCBHQUJBAAABNkVXQlNFSjRZRlZHS0kyQVBCTAACAAAEAQAChebihoaWQSADh2hhMoagk4YEV01QOE5NSjVEOFhPMUFPSTFMOQAFgdih64S2EZmE2pRdhQKGhgYABwAABQEBTlBZAAAGAQECSEsxNE8xQVNBTlBZSE9ORkxMUQADfgAAAAQAAAhIWkVZWFNRT0VETkQyUTZNOTdNAAlQT1oySENQQlQ2MERTREo4VUE3AAoACwE2VDk2MjYwMTI2VFY0S0xHRFhHAAJDUkVIUkNLMllYUldKSzJKMEFMAAMBBAEAAiMwMDAwMDAAA8gBAAUBAQIjMDAwMDAwAAPIAQAAAAFFSVVBTFBZTkdaNVZVN1kyWTAyAAJRWlEyUUJNVTRUNUk0N0QxSzRGAAMFAUUzSEdCWUhSQzk4R0E2Rlc5RjYAAgAAATNYQk9GQlIzMDJFWUMwVVFENTEAAgAAAVNRNldKTzBHTlVKR0ZVOExIVlYAAgAAAUhLMTRPMUFTQU5QWUhPTkZMTFEAAgFTVFIgU1NULUNIT0RMIEdBQkEAAAE2RVdCU0VKNFlGVkdLSTJBUEJMAAIAAAQBAQKBItJbgQi1PgOEXt1mg%2Bp7yQAFAQFOUFkAAAYBAQJISzE0TzFBU0FOUFlIT05GTExRAAN%2BAAAABAAACEZUTEFVT1Y2U0xCMDcxU1ZOVTkACVBPWjJIQ1BCVDYwRFNESjhVQTcACgALAW5vbmUAAm5vbmUAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAggA" xsd:string {name="markers in reference data on Allen Brain Cell Atlas"} [Term] id: CLM:5050525 name: ST18 (CAS evidence). is_a: SO:0001260 ! sequence_collection relationship: BFO:0000051 http://identifiers.org/ncbigene/9705 ! has part ST18 property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#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%2BWYiFjtcfA4YKpk6F9JyqBFdNUDhOTUo1RDhYTzFBT0kxTDkABYQUxBaDjMVShGJpv4S050sGAAcAAAUBAVNUMTgAAAYBAQJISzE0TzFBU0FOUFlIT05GTExRAAN%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%3D" xsd:string {name="markers in reference data on Allen Brain Cell Atlas"} [Term] id: CLM:5050527 name: VIP (CAS evidence). is_a: SO:0001260 ! sequence_collection relationship: BFO:0000051 http://identifiers.org/ncbigene/7432 ! has part VIP property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#AQQBTlhKOU5aQVFBNU1FSFFOT1dKUQACVEdCUTJGRVYyN04wQ1BMS1ZBWgADBQFFM0hHQllIUkM5OEdBNkZXOUY2AAIAAAEzWEJPRkJSMzAyRVlDMFVRRDUxAAIAAAFTUTZXSk8wR05VSkdGVThMSFZWAAIAAAFISzE0TzFBU0FOUFlIT05GTExRAAIBVklQIEdBQkEAAAE2RVdCU0VKNFlGVkdLSTJBUEJMAAIAAAQBAAKEykWZhH5WhgOFDHL%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%2FlmIhY7XHwOGCqZOhfScqgRXTVA4Tk1KNUQ4WE8xQU9JMUw5AAWEFMQWg4zFUoRiab%2BEtOdLBgAHAAAFAQFWSVAAAAYBAQJISzE0TzFBU0FOUFlIT05GTExRAAN%2BAAAABAAACDlBVVRFOVMxMEtBRUMyVVpPMzEACVBPWjJIQ1BCVDYwRFNESjhVQTcACgALAVkzUDFKTTFFTkNHV0VXOFVTVFYAAkNSRUhSQ0syWVhSV0pLMkowQUwAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAATNDUElQMjgwNFNCRFgxRFgxUlcAAlM1S1FURkhDUktIVlpWUlI1SFIAAwUBRTNIR0JZSFJDOThHQTZGVzlGNgACAAABM1hCT0ZCUjMwMkVZQzBVUUQ1MQACAAABU1E2V0pPMEdOVUpHRlU4TEhWVgACAAABSEsxNE8xQVNBTlBZSE9ORkxMUQACAVZJUCBHQUJBAAABNkVXQlNFSjRZRlZHS0kyQVBCTAACAAAEAQAChebihoaWQSADh2hhMoagk4YEV01QOE5NSjVEOFhPMUFPSTFMOQAFgdih64S2EZmE2pRdhQKGhgYABwAABQEBVklQAAAGAQECSEsxNE8xQVNBTlBZSE9ORkxMUQADfgAAAAQAAAhIWkVZWFNRT0VETkQyUTZNOTdNAAlQT1oySENQQlQ2MERTREo4VUE3AAoACwE2VDk2MjYwMTI2VFY0S0xHRFhHAAJDUkVIUkNLMllYUldKSzJKMEFMAAMBBAEAAiMwMDAwMDAAA8gBAAUBAQIjMDAwMDAwAAPIAQAAAAFFSVVBTFBZTkdaNVZVN1kyWTAyAAJRWlEyUUJNVTRUNUk0N0QxSzRGAAMFAUUzSEdCWUhSQzk4R0E2Rlc5RjYAAgAAATNYQk9GQlIzMDJFWUMwVVFENTEAAgAAAVNRNldKTzBHTlVKR0ZVOExIVlYAAgAAAUhLMTRPMUFTQU5QWUhPTkZMTFEAAgFWSVAgR0FCQQAAATZFV0JTRUo0WUZWR0tJMkFQQkwAAgAABAEBAoEi0luBCLU%2BA4Re3WaD6nvJAAUBAVZJUAAABgEBAkhLMTRPMUFTQU5QWUhPTkZMTFEAA34AAAAEAAAIRlRMQVVPVjZTTEIwNzFTVk5VOQAJUE9aMkhDUEJUNjBEU0RKOFVBNwAKAAsBbm9uZQACbm9uZQADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAACCAA%3D" xsd:string {name="markers in reference data on Allen Brain Cell Atlas"} [Term] id: CLM:5050529 name: DRD1, STXBP6 (CAS evidence). is_a: SO:0001260 ! sequence_collection relationship: BFO:0000051 http://identifiers.org/ncbigene/1812 ! has part DRD1 relationship: BFO:0000051 http://identifiers.org/ncbigene/29091 ! has part STXBP6 property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#AQQBTlhKOU5aQVFBNU1FSFFOT1dKUQACVEdCUTJGRVYyN04wQ1BMS1ZBWgADBQFFM0hHQllIUkM5OEdBNkZXOUY2AAIAAAEzWEJPRkJSMzAyRVlDMFVRRDUxAAIAAAFTUTZXSk8wR05VSkdGVThMSFZWAAIAAAFISzE0TzFBU0FOUFlIT05GTExRAAIBU1RSZCBEMSBNYXRyaXggTVNOAAABNkVXQlNFSjRZRlZHS0kyQVBCTAACAAAEAQAChMpFmYR%2BVoYDhQxy%2FoU8XEUEV01QOE5NSjVEOFhPMUFPSTFMOQAFg2xvMYI24kGDwAnEgzgCUgAFAgFEUkQxAAABU1RYQlA2AAAGAQECSEsxNE8xQVNBTlBZSE9ORkxMUQADfgAAAAQAAAhJQTZZNlNON1FaU0lFSjBGWjBVAAlQT1oySENQQlQ2MERTREo4VUE3AAoACwE3NDE2QjVYSkRTWTBIREY5M1JPAAJDUkVIUkNLMllYUldKSzJKMEFMAAMBBAEAAiMwMDAwMDAAA8gBAAUBAQIjMDAwMDAwAAPIAQAAAAFWTTRFNko5RFBZWUQ3RTBCSE5CAAJLR1pMQVdJUENSNFc5OEY1TEQ2AAMFAUUzSEdCWUhSQzk4R0E2Rlc5RjYAAgAAATNYQk9GQlIzMDJFWUMwVVFENTEAAgAAAVNRNldKTzBHTlVKR0ZVOExIVlYAAgAAAUhLMTRPMUFTQU5QWUhPTkZMTFEAAgFTVFJkIEQxIE1hdHJpeCBNU04AAAE2RVdCU0VKNFlGVkdLSTJBUEJMAAIAAAQBAAKF%2FlmIhY7XHwOGCqZOhfScqgRXTVA4Tk1KNUQ4WE8xQU9JMUw5AAWEFMQWg4zFUoRiab%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%2Bp7yQAFAgFEUkQxAAABU1RYQlA2AAAGAQECSEsxNE8xQVNBTlBZSE9ORkxMUQADfgAAAAQAAAhGVExBVU9WNlNMQjA3MVNWTlU5AAlQT1oySENQQlQ2MERTREo4VUE3AAoACwFub25lAAJub25lAAMBBAEAAiMwMDAwMDAAA8gBAAUBAQIjMDAwMDAwAAPIAQAAAAIIAA%3D%3D" xsd:string {name="markers in reference data on Allen Brain Cell Atlas"} [Term] id: CLM:5050530 name: DRD1, KCNIP1 (CAS evidence). is_a: SO:0001260 ! sequence_collection relationship: BFO:0000051 http://identifiers.org/ncbigene/1812 ! has part DRD1 relationship: BFO:0000051 http://identifiers.org/ncbigene/30820 ! has part KCNIP1 property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#AQQBTlhKOU5aQVFBNU1FSFFOT1dKUQACVEdCUTJGRVYyN04wQ1BMS1ZBWgADBQFFM0hHQllIUkM5OEdBNkZXOUY2AAIAAAEzWEJPRkJSMzAyRVlDMFVRRDUxAAIAAAFTUTZXSk8wR05VSkdGVThMSFZWAAIAAAFISzE0TzFBU0FOUFlIT05GTExRAAIBU1RSZCBEMSBTdHJpb3NvbWUgTVNOAAABNkVXQlNFSjRZRlZHS0kyQVBCTAACAAAEAQAChMpFmYR%2BVoYDhQxy%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%2FlmIhY7XHwOGCqZOhfScqgRXTVA4Tk1KNUQ4WE8xQU9JMUw5AAWEFMQWg4zFUoRiab%2BEtOdLBgAHAAAFAgFEUkQxAAABS0NOSVAxAAAGAQECSEsxNE8xQVNBTlBZSE9ORkxMUQADfgAAAAQAAAg5QVVURTlTMTBLQUVDMlVaTzMxAAlQT1oySENQQlQ2MERTREo4VUE3AAoACwFZM1AxSk0xRU5DR1dFVzhVU1RWAAJDUkVIUkNLMllYUldKSzJKMEFMAAMBBAEAAiMwMDAwMDAAA8gBAAUBAQIjMDAwMDAwAAPIAQAAAAEzQ1BJUDI4MDRTQkRYMURYMVJXAAJTNUtRVEZIQ1JLSFZaVlJSNUhSAAMFAUUzSEdCWUhSQzk4R0E2Rlc5RjYAAgAAATNYQk9GQlIzMDJFWUMwVVFENTEAAgAAAVNRNldKTzBHTlVKR0ZVOExIVlYAAgAAAUhLMTRPMUFTQU5QWUhPTkZMTFEAAgFTVFJkIEQxIFN0cmlvc29tZSBNU04AAAE2RVdCU0VKNFlGVkdLSTJBUEJMAAIAAAQBAAKF5uKGhpZBIAOHaGEyhqCThgRXTVA4Tk1KNUQ4WE8xQU9JMUw5AAWB2KHrhLYRmYTalF2FAoaGBgAHAAAFAgFEUkQxAAABS0NOSVAxAAAGAQECSEsxNE8xQVNBTlBZSE9ORkxMUQADfgAAAAQAAAhIWkVZWFNRT0VETkQyUTZNOTdNAAlQT1oySENQQlQ2MERTREo4VUE3AAoACwE2VDk2MjYwMTI2VFY0S0xHRFhHAAJDUkVIUkNLMllYUldKSzJKMEFMAAMBBAEAAiMwMDAwMDAAA8gBAAUBAQIjMDAwMDAwAAPIAQAAAAFFSVVBTFBZTkdaNVZVN1kyWTAyAAJRWlEyUUJNVTRUNUk0N0QxSzRGAAMFAUUzSEdCWUhSQzk4R0E2Rlc5RjYAAgAAATNYQk9GQlIzMDJFWUMwVVFENTEAAgAAAVNRNldKTzBHTlVKR0ZVOExIVlYAAgAAAUhLMTRPMUFTQU5QWUhPTkZMTFEAAgFTVFJkIEQxIFN0cmlvc29tZSBNU04AAAE2RVdCU0VKNFlGVkdLSTJBUEJMAAIAAAQBAQKBItJbgQi1PgOEXt1mg%2Bp7yQAFAgFEUkQxAAABS0NOSVAxAAAGAQECSEsxNE8xQVNBTlBZSE9ORkxMUQADfgAAAAQAAAhGVExBVU9WNlNMQjA3MVNWTlU5AAlQT1oySENQQlQ2MERTREo4VUE3AAoACwFub25lAAJub25lAAMBBAEAAiMwMDAwMDAAA8gBAAUBAQIjMDAwMDAwAAPIAQAAAAIIAA%3D%3D" xsd:string {name="markers in reference data on Allen Brain Cell Atlas"} [Term] id: CLM:5050531 name: DRD1, DRD2, CRHR2, GRIK1 (CAS evidence). is_a: SO:0001260 ! sequence_collection relationship: BFO:0000051 http://identifiers.org/ncbigene/1395 ! has part CRHR2 relationship: BFO:0000051 http://identifiers.org/ncbigene/1812 ! has part DRD1 relationship: BFO:0000051 http://identifiers.org/ncbigene/1813 ! has part DRD2 relationship: BFO:0000051 http://identifiers.org/ncbigene/2897 ! has part GRIK1 property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#AQQBTlhKOU5aQVFBNU1FSFFOT1dKUQACVEdCUTJGRVYyN04wQ1BMS1ZBWgADBQFFM0hHQllIUkM5OEdBNkZXOUY2AAIAAAEzWEJPRkJSMzAyRVlDMFVRRDUxAAIAAAFTUTZXSk8wR05VSkdGVThMSFZWAAIAAAFISzE0TzFBU0FOUFlIT05GTExRAAIBU1RSIEQxRDIgSHlicmlkIE1TTgAAATZFV0JTRUo0WUZWR0tJMkFQQkwAAgAABAEAAoTKRZmEflaGA4UMcv6FPFxFBFdNUDhOTUo1RDhYTzFBT0kxTDkABYNsbzGCNuJBg8AJxIM4AlIABQQBRFJEMQAAAURSRDIAAAFDUkhSMgAAAUdSSUsxAAAGAQECSEsxNE8xQVNBTlBZSE9ORkxMUQADfgAAAAQAAAhJQTZZNlNON1FaU0lFSjBGWjBVAAlQT1oySENQQlQ2MERTREo4VUE3AAoACwE3NDE2QjVYSkRTWTBIREY5M1JPAAJDUkVIUkNLMllYUldKSzJKMEFMAAMBBAEAAiMwMDAwMDAAA8gBAAUBAQIjMDAwMDAwAAPIAQAAAAFWTTRFNko5RFBZWUQ3RTBCSE5CAAJLR1pMQVdJUENSNFc5OEY1TEQ2AAMFAUUzSEdCWUhSQzk4R0E2Rlc5RjYAAgAAATNYQk9GQlIzMDJFWUMwVVFENTEAAgAAAVNRNldKTzBHTlVKR0ZVOExIVlYAAgAAAUhLMTRPMUFTQU5QWUhPTkZMTFEAAgFTVFIgRDFEMiBIeWJyaWQgTVNOAAABNkVXQlNFSjRZRlZHS0kyQVBCTAACAAAEAQAChf5ZiIWO1x8DhgqmToX0nKoEV01QOE5NSjVEOFhPMUFPSTFMOQAFhBTEFoOMxVKEYmm%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%3D%3D" xsd:string {name="markers in reference data on Allen Brain Cell Atlas"} [Term] id: CLM:5050532 name: DRD2, STXBP6 (CAS evidence). is_a: SO:0001260 ! sequence_collection relationship: BFO:0000051 http://identifiers.org/ncbigene/1813 ! has part DRD2 relationship: BFO:0000051 http://identifiers.org/ncbigene/29091 ! has part STXBP6 property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#AQQBTlhKOU5aQVFBNU1FSFFOT1dKUQACVEdCUTJGRVYyN04wQ1BMS1ZBWgADBQFFM0hHQllIUkM5OEdBNkZXOUY2AAIAAAEzWEJPRkJSMzAyRVlDMFVRRDUxAAIAAAFTUTZXSk8wR05VSkdGVThMSFZWAAIAAAFISzE0TzFBU0FOUFlIT05GTExRAAIBU1RSZCBEMiBNYXRyaXggTVNOAAABNkVXQlNFSjRZRlZHS0kyQVBCTAACAAAEAQAChMpFmYR%2BVoYDhQxy%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%2FlmIhY7XHwOGCqZOhfScqgRXTVA4Tk1KNUQ4WE8xQU9JMUw5AAWEFMQWg4zFUoRiab%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%2Bp7yQAFAgFEUkQyAAABU1RYQlA2AAAGAQECSEsxNE8xQVNBTlBZSE9ORkxMUQADfgAAAAQAAAhGVExBVU9WNlNMQjA3MVNWTlU5AAlQT1oySENQQlQ2MERTREo4VUE3AAoACwFub25lAAJub25lAAMBBAEAAiMwMDAwMDAAA8gBAAUBAQIjMDAwMDAwAAPIAQAAAAIIAA%3D%3D" xsd:string {name="markers in reference data on Allen Brain Cell Atlas"} [Term] id: CLM:5050534 name: DRD2, KCNIP1 (CAS evidence). is_a: SO:0001260 ! sequence_collection relationship: BFO:0000051 http://identifiers.org/ncbigene/1813 ! has part DRD2 relationship: BFO:0000051 http://identifiers.org/ncbigene/30820 ! has part KCNIP1 property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#AQQBTlhKOU5aQVFBNU1FSFFOT1dKUQACVEdCUTJGRVYyN04wQ1BMS1ZBWgADBQFFM0hHQllIUkM5OEdBNkZXOUY2AAIAAAEzWEJPRkJSMzAyRVlDMFVRRDUxAAIAAAFTUTZXSk8wR05VSkdGVThMSFZWAAIAAAFISzE0TzFBU0FOUFlIT05GTExRAAIBU1RSZCBEMiBTdHJpb3NvbWUgTVNOAAABNkVXQlNFSjRZRlZHS0kyQVBCTAACAAAEAQAChMpFmYR%2BVoYDhQxy%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%2FlmIhY7XHwOGCqZOhfScqgRXTVA4Tk1KNUQ4WE8xQU9JMUw5AAWEFMQWg4zFUoRiab%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%2Bp7yQAFAgFEUkQyAAABS0NOSVAxAAAGAQECSEsxNE8xQVNBTlBZSE9ORkxMUQADfgAAAAQAAAhGVExBVU9WNlNMQjA3MVNWTlU5AAlQT1oySENQQlQ2MERTREo4VUE3AAoACwFub25lAAJub25lAAMBBAEAAiMwMDAwMDAAA8gBAAUBAQIjMDAwMDAwAAPIAQAAAAIIAA%3D%3D" xsd:string {name="markers in reference data on Allen Brain Cell Atlas"} [Term] id: CLM:5050536 name: DRD1, ARHGAP6 (CAS evidence). is_a: SO:0001260 ! sequence_collection relationship: BFO:0000051 http://identifiers.org/ncbigene/1812 ! has part DRD1 relationship: BFO:0000051 http://identifiers.org/ncbigene/395 ! has part ARHGAP6 property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#AQQBTlhKOU5aQVFBNU1FSFFOT1dKUQACVEdCUTJGRVYyN04wQ1BMS1ZBWgADBQFFM0hHQllIUkM5OEdBNkZXOUY2AAIAAAEzWEJPRkJSMzAyRVlDMFVRRDUxAAIAAAFTUTZXSk8wR05VSkdGVThMSFZWAAIAAAFISzE0TzFBU0FOUFlIT05GTExRAAIBU1RSdiBEMSBNU04AAAE2RVdCU0VKNFlGVkdLSTJBUEJMAAIAAAQBAAKEykWZhH5WhgOFDHL%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%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%2BA4Re3WaD6nvJAAUCAURSRDEAAAFBUkhHQVA2AAAGAQECSEsxNE8xQVNBTlBZSE9ORkxMUQADfgAAAAQAAAhGVExBVU9WNlNMQjA3MVNWTlU5AAlQT1oySENQQlQ2MERTREo4VUE3AAoACwFub25lAAJub25lAAMBBAEAAiMwMDAwMDAAA8gBAAUBAQIjMDAwMDAwAAPIAQAAAAIIAA%3D%3D" xsd:string {name="markers in reference data on Allen Brain Cell Atlas"} [Term] id: CLM:5050537 name: DRD1, GRIA4 (CAS evidence). is_a: SO:0001260 ! sequence_collection relationship: BFO:0000051 http://identifiers.org/ncbigene/1812 ! has part DRD1 relationship: BFO:0000051 http://identifiers.org/ncbigene/2893 ! has part GRIA4 property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#AQQBTlhKOU5aQVFBNU1FSFFOT1dKUQACVEdCUTJGRVYyN04wQ1BMS1ZBWgADBQFFM0hHQllIUkM5OEdBNkZXOUY2AAIAAAEzWEJPRkJSMzAyRVlDMFVRRDUxAAIAAAFTUTZXSk8wR05VSkdGVThMSFZWAAIAAAFISzE0TzFBU0FOUFlIT05GTExRAAIBU1RSdiBEMSBOVURBUCBNU04AAAE2RVdCU0VKNFlGVkdLSTJBUEJMAAIAAAQBAAKEykWZhH5WhgOFDHL%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%2FlmIhY7XHwOGCqZOhfScqgRXTVA4Tk1KNUQ4WE8xQU9JMUw5AAWEFMQWg4zFUoRiab%2BEtOdLBgAHAAAFAgFEUkQxAAABR1JJQTQAAAYBAQJISzE0TzFBU0FOUFlIT05GTExRAAN%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%2BA4Re3WaD6nvJAAUCAURSRDEAAAFHUklBNAAABgEBAkhLMTRPMUFTQU5QWUhPTkZMTFEAA34AAAAEAAAIRlRMQVVPVjZTTEIwNzFTVk5VOQAJUE9aMkhDUEJUNjBEU0RKOFVBNwAKAAsBbm9uZQACbm9uZQADAQQBAAIjMDAwMDAwAAPIAQAFAQECIzAwMDAwMAADyAEAAAACCAA%3D" xsd:string {name="markers in reference data on Allen Brain Cell Atlas"} [Term] id: CLM:5050538 name: DRD2, ARHGAP6 (CAS evidence). is_a: SO:0001260 ! sequence_collection relationship: BFO:0000051 http://identifiers.org/ncbigene/1813 ! has part DRD2 relationship: BFO:0000051 http://identifiers.org/ncbigene/395 ! has part ARHGAP6 property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#AQQBTlhKOU5aQVFBNU1FSFFOT1dKUQACVEdCUTJGRVYyN04wQ1BMS1ZBWgADBQFFM0hHQllIUkM5OEdBNkZXOUY2AAIAAAEzWEJPRkJSMzAyRVlDMFVRRDUxAAIAAAFTUTZXSk8wR05VSkdGVThMSFZWAAIAAAFISzE0TzFBU0FOUFlIT05GTExRAAIBU1RSdiBEMiBNU04AAAE2RVdCU0VKNFlGVkdLSTJBUEJMAAIAAAQBAAKEykWZhH5WhgOFDHL%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%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%2BA4Re3WaD6nvJAAUCAURSRDIAAAFBUkhHQVA2AAAGAQECSEsxNE8xQVNBTlBZSE9ORkxMUQADfgAAAAQAAAhGVExBVU9WNlNMQjA3MVNWTlU5AAlQT1oySENQQlQ2MERTREo4VUE3AAoACwFub25lAAJub25lAAMBBAEAAiMwMDAwMDAAA8gBAAUBAQIjMDAwMDAwAAPIAQAAAAIIAA%3D%3D" xsd:string {name="markers in reference data on Allen Brain Cell Atlas"} [Term] id: CLM:5050544 name: SLC17A6 (CAS evidence). is_a: SO:0001260 ! sequence_collection relationship: BFO:0000051 http://identifiers.org/ncbigene/57084 ! has part SLC17A6 property_value: seeAlso "https://knowledge.brain-map.org/abcatlas#AQQBTlhKOU5aQVFBNU1FSFFOT1dKUQACVEdCUTJGRVYyN04wQ1BMS1ZBWgADBQFFM0hHQllIUkM5OEdBNkZXOUY2AAIAAAEzWEJPRkJSMzAyRVlDMFVRRDUxAAIAAAFTUTZXSk8wR05VSkdGVThMSFZWAAIAAAFISzE0TzFBU0FOUFlIT05GTExRAAIBVlRSLUhUSCBHbHV0AAABNkVXQlNFSjRZRlZHS0kyQVBCTAACAAAEAQAChMpFmYR%2BVoYDhQxy%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%2FlmIhY7XHwOGCqZOhfScqgRXTVA4Tk1KNUQ4WE8xQU9JMUw5AAWEFMQWg4zFUoRiab%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%2Bp7yQAFAQFTTEMxN0E2AAAGAQECSEsxNE8xQVNBTlBZSE9ORkxMUQADfgAAAAQAAAhGVExBVU9WNlNMQjA3MVNWTlU5AAlQT1oySENQQlQ2MERTREo4VUE3AAoACwFub25lAAJub25lAAMBBAEAAiMwMDAwMDAAA8gBAAUBAQIjMDAwMDAwAAPIAQAAAAIIAA%3D%3D" xsd:string {name="markers in reference data on Allen Brain Cell Atlas"} [Term] id: CP:0000000 name: obsolete CP:0000000 comment: ID was moved to the CL namespace. Use CL:0017500. is_obsolete: true replaced_by: CL:0017500 [Term] id: CP:0000025 name: obsolete CP:0000025 comment: ID was moved to the CL namespace. Use CL:0017501. is_obsolete: true replaced_by: CL:0017501 [Term] id: CP:0000027 name: obsolete CP:0000027 comment: ID was moved to the CL namespace. Use CL:0017502. is_obsolete: true replaced_by: CL:0017502 [Term] id: CP:0000028 name: obsolete CP:0000028 comment: ID was moved to the CL namespace. Use CL:0017503. is_obsolete: true replaced_by: CL:0017503 [Term] id: CP:0000035 name: obsolete CP:0000035 comment: ID was moved to the CL namespace. Use CL:0017504. is_obsolete: true replaced_by: CL:0017504 [Term] id: CP:0000037 name: obsolete CP:0000037 comment: ID was moved to the CL namespace. Use CL:0017505. is_obsolete: true replaced_by: CL:0017505 [Term] id: CP:0000039 name: obsolete CP:0000039 comment: ID was moved to the CL namespace. Use CL:0017506. is_obsolete: true replaced_by: CL:0017506 [Term] id: CP:0000040 name: obsolete CP:0000040 comment: ID was moved to the CL namespace. Use CL:0017507. is_obsolete: true replaced_by: CL:0017507 [Term] id: CP:0000043 name: obsolete CP:0000043 comment: ID was moved to the CL namespace. Use CL:0017508. is_obsolete: true replaced_by: CL:0017508 [Term] id: DHBA:10153 name: neural plate synonym: "NP" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=138322603#structure=10153 xref: http://atlas.brain-map.org/atlas?atlas=138322605#structure=10153 xref: http://atlas.brain-map.org/atlas?atlas=265297126#structure=10153 xref: http://atlas.brain-map.org/atlas?atlas=3#structure=10153 is_a: UBERON:0003075 ! neural plate intersection_of: UBERON:0003075 ! neural plate intersection_of: RO:0002162 NCBITaxon:9606 ! in taxon Homo sapiens relationship: BFO:0000050 NCBITaxon:9606 ! part of Homo sapiens relationship: RO:0002162 NCBITaxon:9606 ! in taxon Homo sapiens property_value: IAO:0000028 "NP" xsd:string property_value: skos:prefLabel "neural plate ( human dev )" xsd:string [Term] id: DHBA:10154 name: neural tube synonym: "NT" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=138322603#structure=10154 xref: http://atlas.brain-map.org/atlas?atlas=138322605#structure=10154 xref: http://atlas.brain-map.org/atlas?atlas=265297126#structure=10154 xref: http://atlas.brain-map.org/atlas?atlas=3#structure=10154 is_a: UBERON:0001049 ! neural tube intersection_of: UBERON:0001049 ! neural tube intersection_of: RO:0002162 NCBITaxon:9606 ! in taxon Homo sapiens relationship: BFO:0000050 DHBA:10153 ! part of neural plate property_value: IAO:0000028 "NT" xsd:string property_value: skos:prefLabel "neural tube ( human dev )" xsd:string [Term] id: DHBA:10155 name: brain synonym: "Br" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=138322603#structure=10155 xref: http://atlas.brain-map.org/atlas?atlas=138322605#structure=10155 xref: http://atlas.brain-map.org/atlas?atlas=265297126#structure=10155 xref: http://atlas.brain-map.org/atlas?atlas=3#structure=10155 is_a: UBERON:0008823 ! neural tube derived brain intersection_of: UBERON:0000955 ! brain intersection_of: RO:0002162 NCBITaxon:9606 ! in taxon Homo sapiens relationship: BFO:0000050 DHBA:10154 ! part of neural tube property_value: IAO:0000028 "Br" xsd:string property_value: skos:prefLabel "brain ( human dev )" xsd:string [Term] id: DHBA:10156 name: forebrain (prosencephalon) synonym: "F" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=138322603#structure=10156 xref: http://atlas.brain-map.org/atlas?atlas=138322605#structure=10156 xref: http://atlas.brain-map.org/atlas?atlas=265297126#structure=10156 xref: http://atlas.brain-map.org/atlas?atlas=3#structure=10156 is_a: UBERON:0001890 ! forebrain intersection_of: UBERON:0001890 ! forebrain intersection_of: RO:0002162 NCBITaxon:9606 ! in taxon Homo sapiens relationship: BFO:0000050 DHBA:10155 ! part of brain property_value: IAO:0000028 "F" xsd:string property_value: skos:prefLabel "forebrain (prosencephalon) ( human dev )" xsd:string [Term] id: DHBA:10157 name: gray matter of forebrain synonym: "FGM" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=138322603#structure=10157 xref: http://atlas.brain-map.org/atlas?atlas=138322605#structure=10157 xref: http://atlas.brain-map.org/atlas?atlas=265297126#structure=10157 xref: http://atlas.brain-map.org/atlas?atlas=3#structure=10157 is_a: UBERON:0019264 ! gray matter of forebrain intersection_of: UBERON:0019264 ! gray matter of forebrain intersection_of: RO:0002162 NCBITaxon:9606 ! in taxon Homo sapiens relationship: BFO:0000050 DHBA:10156 ! part of forebrain (prosencephalon) property_value: IAO:0000028 "FGM" xsd:string property_value: skos:prefLabel "gray matter of forebrain ( human dev )" xsd:string [Term] id: DHBA:10158 name: telencephalon synonym: "Tel" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=138322603#structure=10158 xref: http://atlas.brain-map.org/atlas?atlas=138322605#structure=10158 xref: http://atlas.brain-map.org/atlas?atlas=265297126#structure=10158 xref: http://atlas.brain-map.org/atlas?atlas=3#structure=10158 is_a: UBERON:0001893 ! telencephalon intersection_of: UBERON:0001893 ! telencephalon intersection_of: RO:0002162 NCBITaxon:9606 ! in taxon Homo sapiens relationship: BFO:0000050 DHBA:10157 ! part of gray matter of forebrain property_value: IAO:0000028 "Tel" xsd:string property_value: skos:prefLabel "telencephalon ( human dev )" xsd:string [Term] id: DHBA:10159 name: cerebral cortex synonym: "Cx" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=138322603#structure=10159 xref: http://atlas.brain-map.org/atlas?atlas=138322605#structure=10159 xref: http://atlas.brain-map.org/atlas?atlas=265297126#structure=10159 xref: http://atlas.brain-map.org/atlas?atlas=3#structure=10159 is_a: UBERON:0000956 ! cerebral cortex intersection_of: UBERON:0000956 ! cerebral cortex intersection_of: RO:0002162 NCBITaxon:9606 ! in taxon Homo sapiens relationship: BFO:0000050 DHBA:10158 ! part of telencephalon property_value: IAO:0000028 "Cx" xsd:string property_value: skos:prefLabel "cerebral cortex ( human dev )" xsd:string [Term] id: DHBA:10160 name: neocortex (isocortex) synonym: "NCx" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=138322603#structure=10160 xref: http://atlas.brain-map.org/atlas?atlas=138322605#structure=10160 xref: http://atlas.brain-map.org/atlas?atlas=265297126#structure=10160 xref: http://atlas.brain-map.org/atlas?atlas=3#structure=10160 is_a: UBERON:0001950 ! neocortex intersection_of: UBERON:0001950 ! neocortex intersection_of: RO:0002162 NCBITaxon:9606 ! in taxon Homo sapiens relationship: BFO:0000050 DHBA:10159 ! part of cerebral cortex property_value: IAO:0000028 "NCx" xsd:string property_value: skos:prefLabel "neocortex (isocortex) ( human dev )" xsd:string [Term] id: DHBA:10161 name: frontal neocortex synonym: "FCx" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=138322603#structure=10161 xref: http://atlas.brain-map.org/atlas?atlas=138322605#structure=10161 xref: http://atlas.brain-map.org/atlas?atlas=265297126#structure=10161 xref: http://atlas.brain-map.org/atlas?atlas=3#structure=10161 is_a: DHBA:10157 ! gray matter of forebrain is_a: UBERON:0001870 ! frontal cortex intersection_of: UBERON:0001870 ! frontal cortex intersection_of: RO:0002162 NCBITaxon:9606 ! in taxon Homo sapiens relationship: BFO:0000050 DHBA:10160 ! part of neocortex (isocortex) property_value: IAO:0000028 "FCx" xsd:string property_value: skos:prefLabel "frontal neocortex ( human dev )" xsd:string [Term] id: DHBA:10162 name: posterior frontal cortex (motor cortex) synonym: "PoFC" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=138322603#structure=10162 xref: http://atlas.brain-map.org/atlas?atlas=138322605#structure=10162 xref: http://atlas.brain-map.org/atlas?atlas=265297126#structure=10162 xref: http://atlas.brain-map.org/atlas?atlas=3#structure=10162 is_a: UBERON:0001384 ! primary motor cortex intersection_of: UBERON:0001384 ! primary motor cortex intersection_of: RO:0002162 NCBITaxon:9606 ! in taxon Homo sapiens relationship: BFO:0000050 DHBA:10161 ! part of frontal neocortex property_value: IAO:0000028 "PoFC" xsd:string property_value: skos:prefLabel "posterior frontal cortex (motor cortex) ( human dev )" xsd:string [Term] id: DHBA:10168 name: premotor cortex (area 6) synonym: "PMC" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=138322603#structure=10168 xref: http://atlas.brain-map.org/atlas?atlas=138322605#structure=10168 xref: http://atlas.brain-map.org/atlas?atlas=265297126#structure=10168 xref: http://atlas.brain-map.org/atlas?atlas=3#structure=10168 is_a: UBERON:0016634 ! premotor cortex intersection_of: UBERON:0016634 ! premotor cortex intersection_of: RO:0002162 NCBITaxon:9606 ! in taxon Homo sapiens relationship: BFO:0000050 DHBA:10162 ! part of posterior frontal cortex (motor cortex) property_value: IAO:0000028 "PMC" xsd:string property_value: skos:prefLabel "premotor cortex (area 6) ( human dev )" xsd:string [Term] id: DHBA:10208 name: parietal neocortex synonym: "PCx" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=138322603#structure=10208 xref: http://atlas.brain-map.org/atlas?atlas=138322605#structure=10208 xref: http://atlas.brain-map.org/atlas?atlas=265297126#structure=10208 xref: http://atlas.brain-map.org/atlas?atlas=3#structure=10208 is_a: DHBA:10157 ! gray matter of forebrain is_a: UBERON:0016530 ! parietal cortex intersection_of: UBERON:0016530 ! parietal cortex intersection_of: RO:0002162 NCBITaxon:9606 ! in taxon Homo sapiens relationship: BFO:0000050 DHBA:10160 ! part of neocortex (isocortex) property_value: IAO:0000028 "PCx" xsd:string property_value: skos:prefLabel "parietal neocortex ( human dev )" xsd:string [Term] id: DHBA:10235 name: temporal neocortex synonym: "TCx" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=138322603#structure=10235 xref: http://atlas.brain-map.org/atlas?atlas=138322605#structure=10235 xref: http://atlas.brain-map.org/atlas?atlas=265297126#structure=10235 xref: http://atlas.brain-map.org/atlas?atlas=3#structure=10235 is_a: DHBA:10157 ! gray matter of forebrain is_a: UBERON:0016538 ! temporal cortex intersection_of: UBERON:0016538 ! temporal cortex intersection_of: RO:0002162 NCBITaxon:9606 ! in taxon Homo sapiens relationship: BFO:0000050 DHBA:10160 ! part of neocortex (isocortex) property_value: IAO:0000028 "TCx" xsd:string property_value: skos:prefLabel "temporal neocortex ( human dev )" xsd:string [Term] id: DHBA:10292 name: allocortex synonym: "ACx" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=138322603#structure=10292 xref: http://atlas.brain-map.org/atlas?atlas=138322605#structure=10292 xref: http://atlas.brain-map.org/atlas?atlas=265297126#structure=10292 xref: http://atlas.brain-map.org/atlas?atlas=3#structure=10292 is_a: UBERON:0014734 ! allocortex intersection_of: UBERON:0014734 ! allocortex intersection_of: RO:0002162 NCBITaxon:9606 ! in taxon Homo sapiens relationship: BFO:0000050 DHBA:10159 ! part of cerebral cortex property_value: IAO:0000028 "ACx" xsd:string property_value: skos:prefLabel "allocortex ( human dev )" xsd:string [Term] id: DHBA:10293 name: archicortex synonym: "ArCx" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=138322603#structure=10293 xref: http://atlas.brain-map.org/atlas?atlas=138322605#structure=10293 xref: http://atlas.brain-map.org/atlas?atlas=265297126#structure=10293 xref: http://atlas.brain-map.org/atlas?atlas=3#structure=10293 is_a: DHBA:10292 ! allocortex is_a: UBERON:0002961 ! archicortex intersection_of: UBERON:0002961 ! archicortex intersection_of: RO:0002162 NCBITaxon:9606 ! in taxon Homo sapiens relationship: BFO:0000050 DHBA:10292 ! part of allocortex property_value: IAO:0000028 "ArCx" xsd:string property_value: skos:prefLabel "archicortex ( human dev )" xsd:string [Term] id: DHBA:10294 name: hippocampus (hippocampal formation) synonym: "HIP" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=138322603#structure=10294 xref: http://atlas.brain-map.org/atlas?atlas=138322605#structure=10294 xref: http://atlas.brain-map.org/atlas?atlas=265297126#structure=10294 xref: http://atlas.brain-map.org/atlas?atlas=3#structure=10294 is_a: UBERON:0002421 ! hippocampal formation intersection_of: UBERON:0002421 ! hippocampal formation intersection_of: RO:0002162 NCBITaxon:9606 ! in taxon Homo sapiens relationship: BFO:0000050 DHBA:10293 ! part of archicortex property_value: IAO:0000028 "HIP" xsd:string property_value: skos:prefLabel "hippocampus (hippocampal formation) ( human dev )" xsd:string [Term] id: DHBA:10295 name: dentate area (dentate gyrus) synonym: "DG" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=138322603#structure=10295 xref: http://atlas.brain-map.org/atlas?atlas=138322605#structure=10295 xref: http://atlas.brain-map.org/atlas?atlas=265297126#structure=10295 xref: http://atlas.brain-map.org/atlas?atlas=3#structure=10295 is_a: UBERON:0000200 ! gyrus is_a: UBERON:0001885 ! dentate gyrus of hippocampal formation intersection_of: UBERON:0001885 ! dentate gyrus of hippocampal formation intersection_of: RO:0002162 NCBITaxon:9606 ! in taxon Homo sapiens relationship: BFO:0000050 DHBA:10294 ! part of hippocampus (hippocampal formation) property_value: IAO:0000028 "DG" xsd:string property_value: skos:prefLabel "dentate area (dentate gyrus) ( human dev )" xsd:string [Term] id: DHBA:10296 name: hippocampal proper synonym: "Hipp" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=138322603#structure=10296 xref: http://atlas.brain-map.org/atlas?atlas=138322605#structure=10296 xref: http://atlas.brain-map.org/atlas?atlas=265297126#structure=10296 xref: http://atlas.brain-map.org/atlas?atlas=3#structure=10296 is_a: UBERON:0001954 ! Ammon's horn intersection_of: UBERON:0001954 ! Ammon's horn intersection_of: RO:0002162 NCBITaxon:9606 ! in taxon Homo sapiens relationship: BFO:0000050 DHBA:10294 ! part of hippocampus (hippocampal formation) property_value: IAO:0000028 "Hipp" xsd:string property_value: skos:prefLabel "hippocampal proper ( human dev )" xsd:string [Term] id: DHBA:10299 name: CA3 region of Hipp synonym: "CA3" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=138322603#structure=10299 xref: http://atlas.brain-map.org/atlas?atlas=138322605#structure=10299 xref: http://atlas.brain-map.org/atlas?atlas=265297126#structure=10299 xref: http://atlas.brain-map.org/atlas?atlas=3#structure=10299 is_a: UBERON:0003883 ! CA3 field of hippocampus intersection_of: UBERON:0003883 ! CA3 field of hippocampus intersection_of: RO:0002162 NCBITaxon:9606 ! in taxon Homo sapiens relationship: BFO:0000050 DHBA:10296 ! part of hippocampal proper property_value: IAO:0000028 "CA3" xsd:string property_value: skos:prefLabel "CA3 region of Hipp ( human dev )" xsd:string [Term] id: DHBA:10300 name: CA4 region of Hipp synonym: "CA4" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=138322603#structure=10300 xref: http://atlas.brain-map.org/atlas?atlas=138322605#structure=10300 xref: http://atlas.brain-map.org/atlas?atlas=265297126#structure=10300 xref: http://atlas.brain-map.org/atlas?atlas=3#structure=10300 is_a: UBERON:0003884 ! CA4 field of hippocampus intersection_of: UBERON:0003884 ! CA4 field of hippocampus intersection_of: RO:0002162 NCBITaxon:9606 ! in taxon Homo sapiens relationship: BFO:0000050 DHBA:10296 ! part of hippocampal proper property_value: IAO:0000028 "CA4" xsd:string property_value: skos:prefLabel "CA4 region of Hipp ( human dev )" xsd:string [Term] id: DHBA:10301 name: subicular cortex synonym: "Sub" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=138322603#structure=10301 xref: http://atlas.brain-map.org/atlas?atlas=138322605#structure=10301 xref: http://atlas.brain-map.org/atlas?atlas=265297126#structure=10301 xref: http://atlas.brain-map.org/atlas?atlas=3#structure=10301 is_a: BFO:0000004 relationship: BFO:0000050 DHBA:10294 ! part of hippocampus (hippocampal formation) property_value: IAO:0000028 "Sub" xsd:string property_value: skos:prefLabel "subicular cortex ( human dev )" xsd:string [Term] id: DHBA:10302 name: subiculum synonym: "S" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=138322603#structure=10302 xref: http://atlas.brain-map.org/atlas?atlas=138322605#structure=10302 xref: http://atlas.brain-map.org/atlas?atlas=265297126#structure=10302 xref: http://atlas.brain-map.org/atlas?atlas=3#structure=10302 is_a: UBERON:0002191 ! subiculum intersection_of: UBERON:0002191 ! subiculum intersection_of: RO:0002162 NCBITaxon:9606 ! in taxon Homo sapiens relationship: BFO:0000050 DHBA:10301 ! part of subicular cortex property_value: IAO:0000028 "S" xsd:string property_value: skos:prefLabel "subiculum ( human dev )" xsd:string [Term] id: DHBA:10306 name: paleocortex (semicortex) synonym: "PalCx" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=138322603#structure=10306 xref: http://atlas.brain-map.org/atlas?atlas=138322605#structure=10306 xref: http://atlas.brain-map.org/atlas?atlas=265297126#structure=10306 xref: http://atlas.brain-map.org/atlas?atlas=3#structure=10306 is_a: DHBA:10292 ! allocortex is_a: UBERON:0014735 ! paleocortex intersection_of: UBERON:0014735 ! paleocortex intersection_of: RO:0002162 NCBITaxon:9606 ! in taxon Homo sapiens relationship: BFO:0000050 DHBA:10292 ! part of allocortex property_value: IAO:0000028 "PalCx" xsd:string property_value: skos:prefLabel "paleocortex (semicortex) ( human dev )" xsd:string [Term] id: DHBA:10307 name: olfactory bulb synonym: "OB" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=138322603#structure=10307 xref: http://atlas.brain-map.org/atlas?atlas=138322605#structure=10307 xref: http://atlas.brain-map.org/atlas?atlas=265297126#structure=10307 xref: http://atlas.brain-map.org/atlas?atlas=3#structure=10307 is_a: UBERON:0002264 ! olfactory bulb intersection_of: UBERON:0002264 ! olfactory bulb intersection_of: RO:0002162 NCBITaxon:9606 ! in taxon Homo sapiens relationship: BFO:0000050 DHBA:10306 ! part of paleocortex (semicortex) property_value: IAO:0000028 "OB" xsd:string property_value: skos:prefLabel "olfactory bulb ( human dev )" xsd:string [Term] id: DHBA:10308 name: anterior olfactory nucleus synonym: "AON" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=138322603#structure=10308 xref: http://atlas.brain-map.org/atlas?atlas=138322605#structure=10308 xref: http://atlas.brain-map.org/atlas?atlas=265297126#structure=10308 xref: http://atlas.brain-map.org/atlas?atlas=3#structure=10308 is_a: UBERON:0002266 ! anterior olfactory nucleus intersection_of: UBERON:0002266 ! anterior olfactory nucleus intersection_of: RO:0002162 NCBITaxon:9606 ! in taxon Homo sapiens relationship: BFO:0000050 DHBA:10306 ! part of paleocortex (semicortex) property_value: IAO:0000028 "AON" xsd:string property_value: skos:prefLabel "anterior olfactory nucleus ( human dev )" xsd:string [Term] id: DHBA:10309 name: nucleus of lateral olfactory tract synonym: "NLOT" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=138322603#structure=10309 xref: http://atlas.brain-map.org/atlas?atlas=138322605#structure=10309 xref: http://atlas.brain-map.org/atlas?atlas=265297126#structure=10309 xref: http://atlas.brain-map.org/atlas?atlas=3#structure=10309 is_a: UBERON:0002893 ! nucleus of lateral olfactory tract intersection_of: UBERON:0002893 ! nucleus of lateral olfactory tract intersection_of: RO:0002162 NCBITaxon:9606 ! in taxon Homo sapiens relationship: BFO:0000050 DHBA:10306 ! part of paleocortex (semicortex) property_value: IAO:0000028 "NLOT" xsd:string property_value: skos:prefLabel "nucleus of lateral olfactory tract ( human dev )" xsd:string [Term] id: DHBA:10310 name: olfactory tubercle synonym: "OT" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=138322603#structure=10310 xref: http://atlas.brain-map.org/atlas?atlas=138322605#structure=10310 xref: http://atlas.brain-map.org/atlas?atlas=265297126#structure=10310 xref: http://atlas.brain-map.org/atlas?atlas=3#structure=10310 is_a: UBERON:0001883 ! olfactory tubercle intersection_of: UBERON:0001883 ! olfactory tubercle intersection_of: RO:0002162 NCBITaxon:9606 ! in taxon Homo sapiens relationship: BFO:0000050 DHBA:10306 ! part of paleocortex (semicortex) property_value: IAO:0000028 "OT" xsd:string property_value: skos:prefLabel "olfactory tubercle ( human dev )" xsd:string [Term] id: DHBA:10311 name: piriform cortex synonym: "Pir" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=138322603#structure=10311 xref: http://atlas.brain-map.org/atlas?atlas=138322605#structure=10311 xref: http://atlas.brain-map.org/atlas?atlas=265297126#structure=10311 xref: http://atlas.brain-map.org/atlas?atlas=3#structure=10311 is_a: UBERON:0004725 ! piriform cortex intersection_of: UBERON:0004725 ! piriform cortex intersection_of: RO:0002162 NCBITaxon:9606 ! in taxon Homo sapiens relationship: BFO:0000050 DHBA:10306 ! part of paleocortex (semicortex) property_value: IAO:0000028 "Pir" xsd:string property_value: skos:prefLabel "piriform cortex ( human dev )" xsd:string [Term] id: DHBA:10331 name: cerebral nuclei synonym: "CN" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=138322603#structure=10331 xref: http://atlas.brain-map.org/atlas?atlas=138322605#structure=10331 xref: http://atlas.brain-map.org/atlas?atlas=265297126#structure=10331 xref: http://atlas.brain-map.org/atlas?atlas=3#structure=10331 is_a: UBERON:8440012 ! cerebral nuclei intersection_of: UBERON:8440012 ! cerebral nuclei intersection_of: RO:0002162 NCBITaxon:9606 ! in taxon Homo sapiens relationship: BFO:0000050 DHBA:10158 ! part of telencephalon property_value: IAO:0000028 "CN" xsd:string property_value: skos:prefLabel "cerebral nuclei ( human dev )" xsd:string [Term] id: DHBA:10332 name: basal nuclei (basal ganglia) synonym: "BN" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=138322603#structure=10332 xref: http://atlas.brain-map.org/atlas?atlas=138322605#structure=10332 xref: http://atlas.brain-map.org/atlas?atlas=265297126#structure=10332 xref: http://atlas.brain-map.org/atlas?atlas=3#structure=10332 is_a: DHBA:10157 ! gray matter of forebrain is_a: UBERON:0002420 ! basal ganglion is_a: UBERON:0011300 ! gray matter of telencephalon intersection_of: UBERON:0002420 ! basal ganglion intersection_of: RO:0002162 NCBITaxon:9606 ! in taxon Homo sapiens relationship: BFO:0000050 DHBA:10331 ! part of cerebral nuclei property_value: IAO:0000028 "BN" xsd:string property_value: skos:prefLabel "basal nuclei (basal ganglia) ( human dev )" xsd:string [Term] id: DHBA:10333 name: striatum synonym: "STR" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=138322603#structure=10333 xref: http://atlas.brain-map.org/atlas?atlas=138322605#structure=10333 xref: http://atlas.brain-map.org/atlas?atlas=265297126#structure=10333 xref: http://atlas.brain-map.org/atlas?atlas=3#structure=10333 is_a: DHBA:10157 ! gray matter of forebrain is_a: UBERON:0002435 ! striatum intersection_of: UBERON:0002435 ! striatum intersection_of: RO:0002162 NCBITaxon:9606 ! in taxon Homo sapiens relationship: BFO:0000050 DHBA:10332 ! part of basal nuclei (basal ganglia) property_value: IAO:0000028 "STR" xsd:string property_value: skos:prefLabel "striatum ( human dev )" xsd:string [Term] id: DHBA:10334 name: caudate nucleus synonym: "Ca" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=138322603#structure=10334 xref: http://atlas.brain-map.org/atlas?atlas=138322605#structure=10334 xref: http://atlas.brain-map.org/atlas?atlas=265297126#structure=10334 xref: http://atlas.brain-map.org/atlas?atlas=3#structure=10334 is_a: UBERON:0001873 ! caudate nucleus intersection_of: UBERON:0001873 ! caudate nucleus intersection_of: RO:0002162 NCBITaxon:9606 ! in taxon Homo sapiens relationship: BFO:0000050 DHBA:10333 ! part of striatum property_value: IAO:0000028 "Ca" xsd:string property_value: skos:prefLabel "caudate nucleus ( human dev )" xsd:string [Term] id: DHBA:10338 name: putamen synonym: "Pu" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=138322603#structure=10338 xref: http://atlas.brain-map.org/atlas?atlas=138322605#structure=10338 xref: http://atlas.brain-map.org/atlas?atlas=265297126#structure=10338 xref: http://atlas.brain-map.org/atlas?atlas=3#structure=10338 is_a: UBERON:0001874 ! putamen intersection_of: UBERON:0001874 ! putamen intersection_of: RO:0002162 NCBITaxon:9606 ! in taxon Homo sapiens relationship: BFO:0000050 DHBA:10333 ! part of striatum property_value: IAO:0000028 "Pu" xsd:string property_value: skos:prefLabel "putamen ( human dev )" xsd:string [Term] id: DHBA:10339 name: nucleus accumbens synonym: "NAC" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=138322603#structure=10339 xref: http://atlas.brain-map.org/atlas?atlas=138322605#structure=10339 xref: http://atlas.brain-map.org/atlas?atlas=265297126#structure=10339 xref: http://atlas.brain-map.org/atlas?atlas=3#structure=10339 is_a: UBERON:0001882 ! nucleus accumbens intersection_of: UBERON:0001882 ! nucleus accumbens intersection_of: RO:0002162 NCBITaxon:9606 ! in taxon Homo sapiens relationship: BFO:0000050 DHBA:10333 ! part of striatum property_value: IAO:0000028 "NAC" xsd:string property_value: skos:prefLabel "nucleus accumbens ( human dev )" xsd:string [Term] id: DHBA:10342 name: globus pallidus synonym: "GP" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=138322603#structure=10342 xref: http://atlas.brain-map.org/atlas?atlas=138322605#structure=10342 xref: http://atlas.brain-map.org/atlas?atlas=265297126#structure=10342 xref: http://atlas.brain-map.org/atlas?atlas=3#structure=10342 is_a: UBERON:0001875 ! globus pallidus intersection_of: UBERON:0001875 ! globus pallidus intersection_of: RO:0002162 NCBITaxon:9606 ! in taxon Homo sapiens relationship: BFO:0000050 DHBA:10332 ! part of basal nuclei (basal ganglia) property_value: IAO:0000028 "GP" xsd:string property_value: skos:prefLabel "globus pallidus ( human dev )" xsd:string [Term] id: DHBA:10343 name: external segment of globus pallidus synonym: "GPe" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=138322603#structure=10343 xref: http://atlas.brain-map.org/atlas?atlas=138322605#structure=10343 xref: http://atlas.brain-map.org/atlas?atlas=265297126#structure=10343 xref: http://atlas.brain-map.org/atlas?atlas=3#structure=10343 is_a: BFO:0000004 relationship: BFO:0000050 DHBA:10342 ! part of globus pallidus property_value: IAO:0000028 "GPe" xsd:string property_value: skos:prefLabel "external segment of globus pallidus ( human dev )" xsd:string [Term] id: DHBA:10344 name: internal segment of globus pallidus synonym: "GPi" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=138322603#structure=10344 xref: http://atlas.brain-map.org/atlas?atlas=138322605#structure=10344 xref: http://atlas.brain-map.org/atlas?atlas=265297126#structure=10344 xref: http://atlas.brain-map.org/atlas?atlas=3#structure=10344 is_a: DHBA:10157 ! gray matter of forebrain is_a: UBERON:0002477 ! medial globus pallidus intersection_of: UBERON:0002477 ! medial globus pallidus intersection_of: RO:0002162 NCBITaxon:9606 ! in taxon Homo sapiens relationship: BFO:0000050 DHBA:10342 ! part of globus pallidus property_value: IAO:0000028 "GPi" xsd:string property_value: skos:prefLabel "internal segment of globus pallidus ( human dev )" xsd:string [Term] id: DHBA:10349 name: basal forebrain synonym: "BF" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=138322603#structure=10349 xref: http://atlas.brain-map.org/atlas?atlas=138322605#structure=10349 xref: http://atlas.brain-map.org/atlas?atlas=265297126#structure=10349 xref: http://atlas.brain-map.org/atlas?atlas=3#structure=10349 is_a: UBERON:0002743 ! basal forebrain intersection_of: UBERON:0002743 ! basal forebrain intersection_of: RO:0002162 NCBITaxon:9606 ! in taxon Homo sapiens relationship: BFO:0000050 DHBA:10331 ! part of cerebral nuclei property_value: IAO:0000028 "BF" xsd:string property_value: skos:prefLabel "basal forebrain ( human dev )" xsd:string [Term] id: DHBA:10350 name: septal nuclei synonym: "SEP" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=138322603#structure=10350 xref: http://atlas.brain-map.org/atlas?atlas=138322605#structure=10350 xref: http://atlas.brain-map.org/atlas?atlas=265297126#structure=10350 xref: http://atlas.brain-map.org/atlas?atlas=3#structure=10350 is_a: DHBA:10157 ! gray matter of forebrain is_a: UBERON:0002663 ! septal nuclear complex intersection_of: UBERON:0002663 ! septal nuclear complex intersection_of: RO:0002162 NCBITaxon:9606 ! in taxon Homo sapiens relationship: BFO:0000050 DHBA:10349 ! part of basal forebrain property_value: IAO:0000028 "SEP" xsd:string property_value: skos:prefLabel "septal nuclei ( human dev )" xsd:string [Term] id: DHBA:10351 name: medial septal nucleus synonym: "MSN" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=138322603#structure=10351 xref: http://atlas.brain-map.org/atlas?atlas=138322605#structure=10351 xref: http://atlas.brain-map.org/atlas?atlas=265297126#structure=10351 xref: http://atlas.brain-map.org/atlas?atlas=3#structure=10351 is_a: UBERON:0001877 ! medial septal nucleus intersection_of: UBERON:0001877 ! medial septal nucleus intersection_of: RO:0002162 NCBITaxon:9606 ! in taxon Homo sapiens relationship: BFO:0000050 DHBA:10350 ! part of septal nuclei property_value: IAO:0000028 "MSN" xsd:string property_value: skos:prefLabel "medial septal nucleus ( human dev )" xsd:string [Term] id: DHBA:10352 name: lateral septal nucleus synonym: "LSN" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=138322603#structure=10352 xref: http://atlas.brain-map.org/atlas?atlas=138322605#structure=10352 xref: http://atlas.brain-map.org/atlas?atlas=265297126#structure=10352 xref: http://atlas.brain-map.org/atlas?atlas=3#structure=10352 is_a: UBERON:0002667 ! lateral septal nucleus intersection_of: UBERON:0002667 ! lateral septal nucleus intersection_of: RO:0002162 NCBITaxon:9606 ! in taxon Homo sapiens relationship: BFO:0000050 DHBA:10350 ! part of septal nuclei property_value: IAO:0000028 "LSN" xsd:string property_value: skos:prefLabel "lateral septal nucleus ( human dev )" xsd:string [Term] id: DHBA:10354 name: nucleus of diagonal band synonym: "NDB" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=138322603#structure=10354 xref: http://atlas.brain-map.org/atlas?atlas=138322605#structure=10354 xref: http://atlas.brain-map.org/atlas?atlas=265297126#structure=10354 xref: http://atlas.brain-map.org/atlas?atlas=3#structure=10354 is_a: UBERON:0001879 ! nucleus of diagonal band intersection_of: UBERON:0001879 ! nucleus of diagonal band intersection_of: RO:0002162 NCBITaxon:9606 ! in taxon Homo sapiens relationship: BFO:0000050 DHBA:10349 ! part of basal forebrain property_value: IAO:0000028 "NDB" xsd:string property_value: skos:prefLabel "nucleus of diagonal band ( human dev )" xsd:string [Term] id: DHBA:10358 name: islands of Calleja synonym: "IsCj" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=138322603#structure=10358 xref: http://atlas.brain-map.org/atlas?atlas=138322605#structure=10358 xref: http://atlas.brain-map.org/atlas?atlas=265297126#structure=10358 xref: http://atlas.brain-map.org/atlas?atlas=3#structure=10358 is_a: UBERON:0001881 ! island of Calleja intersection_of: UBERON:0001881 ! island of Calleja intersection_of: RO:0002162 NCBITaxon:9606 ! in taxon Homo sapiens relationship: BFO:0000050 DHBA:10349 ! part of basal forebrain property_value: IAO:0000028 "IsCj" xsd:string property_value: skos:prefLabel "islands of Calleja ( human dev )" xsd:string [Term] id: DHBA:10361 name: amygdaloid complex synonym: "AMY" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=138322603#structure=10361 xref: http://atlas.brain-map.org/atlas?atlas=138322605#structure=10361 xref: http://atlas.brain-map.org/atlas?atlas=265297126#structure=10361 xref: http://atlas.brain-map.org/atlas?atlas=3#structure=10361 is_a: DHBA:10332 ! basal nuclei (basal ganglia) is_a: UBERON:0001876 ! amygdala intersection_of: UBERON:0001876 ! amygdala intersection_of: RO:0002162 NCBITaxon:9606 ! in taxon Homo sapiens property_value: IAO:0000028 "AMY" xsd:string property_value: skos:prefLabel "amygdaloid complex ( human dev )" xsd:string [Term] id: DHBA:10366 name: basolateral nuclear group synonym: "BLN" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=138322603#structure=10366 xref: http://atlas.brain-map.org/atlas?atlas=138322605#structure=10366 xref: http://atlas.brain-map.org/atlas?atlas=265297126#structure=10366 xref: http://atlas.brain-map.org/atlas?atlas=3#structure=10366 is_a: DHBA:10157 ! gray matter of forebrain is_a: UBERON:0006107 ! basolateral amygdaloid nuclear complex intersection_of: UBERON:0006107 ! basolateral amygdaloid nuclear complex intersection_of: RO:0002162 NCBITaxon:9606 ! in taxon Homo sapiens relationship: BFO:0000050 DHBA:10361 ! part of amygdaloid complex property_value: IAO:0000028 "BLN" xsd:string property_value: skos:prefLabel "basolateral nuclear group ( human dev )" xsd:string [Term] id: DHBA:10367 name: lateral nucleus synonym: "La" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=138322603#structure=10367 xref: http://atlas.brain-map.org/atlas?atlas=138322605#structure=10367 xref: http://atlas.brain-map.org/atlas?atlas=265297126#structure=10367 xref: http://atlas.brain-map.org/atlas?atlas=3#structure=10367 is_a: UBERON:0002886 ! lateral amygdaloid nucleus intersection_of: UBERON:0002886 ! lateral amygdaloid nucleus intersection_of: RO:0002162 NCBITaxon:9606 ! in taxon Homo sapiens relationship: BFO:0000050 DHBA:10366 ! part of basolateral nuclear group property_value: IAO:0000028 "La" xsd:string property_value: skos:prefLabel "lateral nucleus ( human dev )" xsd:string [Term] id: DHBA:10372 name: corticomedial nuclear group synonym: "CMN" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=138322603#structure=10372 xref: http://atlas.brain-map.org/atlas?atlas=138322605#structure=10372 xref: http://atlas.brain-map.org/atlas?atlas=265297126#structure=10372 xref: http://atlas.brain-map.org/atlas?atlas=3#structure=10372 is_a: DHBA:10157 ! gray matter of forebrain is_a: UBERON:0006108 ! corticomedial nuclear complex intersection_of: UBERON:0006108 ! corticomedial nuclear complex intersection_of: RO:0002162 NCBITaxon:9606 ! in taxon Homo sapiens relationship: BFO:0000050 DHBA:10361 ! part of amygdaloid complex property_value: IAO:0000028 "CMN" xsd:string property_value: skos:prefLabel "corticomedial nuclear group ( human dev )" xsd:string [Term] id: DHBA:10389 name: diencephalon synonym: "Die" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=138322603#structure=10389 xref: http://atlas.brain-map.org/atlas?atlas=138322605#structure=10389 xref: http://atlas.brain-map.org/atlas?atlas=265297126#structure=10389 xref: http://atlas.brain-map.org/atlas?atlas=3#structure=10389 is_a: UBERON:0001894 ! diencephalon intersection_of: UBERON:0001894 ! diencephalon intersection_of: RO:0002162 NCBITaxon:9606 ! in taxon Homo sapiens relationship: BFO:0000050 DHBA:10157 ! part of gray matter of forebrain property_value: IAO:0000028 "Die" xsd:string property_value: skos:prefLabel "diencephalon ( human dev )" xsd:string [Term] id: DHBA:10390 name: thalamus synonym: "THM" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=138322603#structure=10390 xref: http://atlas.brain-map.org/atlas?atlas=138322605#structure=10390 xref: http://atlas.brain-map.org/atlas?atlas=265297126#structure=10390 xref: http://atlas.brain-map.org/atlas?atlas=3#structure=10390 is_a: UBERON:0001897 ! dorsal plus ventral thalamus intersection_of: UBERON:0001897 ! dorsal plus ventral thalamus intersection_of: RO:0002162 NCBITaxon:9606 ! in taxon Homo sapiens relationship: BFO:0000050 DHBA:10389 ! part of diencephalon property_value: IAO:0000028 "THM" xsd:string property_value: skos:prefLabel "thalamus ( human dev )" xsd:string [Term] id: DHBA:10391 name: dorsal thalamus synonym: "DTH" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=138322603#structure=10391 xref: http://atlas.brain-map.org/atlas?atlas=138322605#structure=10391 xref: http://atlas.brain-map.org/atlas?atlas=265297126#structure=10391 xref: http://atlas.brain-map.org/atlas?atlas=3#structure=10391 is_a: UBERON:0004703 ! dorsal thalamus intersection_of: UBERON:0004703 ! dorsal thalamus intersection_of: RO:0002162 NCBITaxon:9606 ! in taxon Homo sapiens relationship: BFO:0000050 DHBA:10390 ! part of thalamus property_value: IAO:0000028 "DTH" xsd:string property_value: skos:prefLabel "dorsal thalamus ( human dev )" xsd:string [Term] id: DHBA:10406 name: lateral nuclear complex of thalamus synonym: "LNC" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=138322603#structure=10406 xref: http://atlas.brain-map.org/atlas?atlas=138322605#structure=10406 xref: http://atlas.brain-map.org/atlas?atlas=265297126#structure=10406 xref: http://atlas.brain-map.org/atlas?atlas=3#structure=10406 is_a: BFO:0000004 relationship: BFO:0000050 DHBA:10391 ! part of dorsal thalamus property_value: IAO:0000028 "LNC" xsd:string property_value: skos:prefLabel "lateral nuclear complex of thalamus ( human dev )" xsd:string [Term] id: DHBA:10416 name: ventral group of lateral nucleus synonym: "VLN" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=138322603#structure=10416 xref: http://atlas.brain-map.org/atlas?atlas=138322605#structure=10416 xref: http://atlas.brain-map.org/atlas?atlas=265297126#structure=10416 xref: http://atlas.brain-map.org/atlas?atlas=3#structure=10416 is_a: BFO:0000004 relationship: BFO:0000050 DHBA:10406 ! part of lateral nuclear complex of thalamus property_value: IAO:0000028 "VLN" xsd:string property_value: skos:prefLabel "ventral group of lateral nucleus ( human dev )" xsd:string [Term] id: DHBA:10423 name: ventral posterior nucleus of thalamus synonym: "VPT" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=138322603#structure=10423 xref: http://atlas.brain-map.org/atlas?atlas=138322605#structure=10423 xref: http://atlas.brain-map.org/atlas?atlas=265297126#structure=10423 xref: http://atlas.brain-map.org/atlas?atlas=3#structure=10423 is_a: UBERON:0002596 ! ventral posterior nucleus of thalamus intersection_of: UBERON:0002596 ! ventral posterior nucleus of thalamus intersection_of: RO:0002162 NCBITaxon:9606 ! in taxon Homo sapiens relationship: BFO:0000050 DHBA:10416 ! part of ventral group of lateral nucleus property_value: IAO:0000028 "VPT" xsd:string property_value: skos:prefLabel "ventral posterior nucleus of thalamus ( human dev )" xsd:string [Term] id: DHBA:10425 name: ventral posterior medial nucleus synonym: "VPM" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=138322603#structure=10425 xref: http://atlas.brain-map.org/atlas?atlas=138322605#structure=10425 xref: http://atlas.brain-map.org/atlas?atlas=265297126#structure=10425 xref: http://atlas.brain-map.org/atlas?atlas=3#structure=10425 is_a: UBERON:0002945 ! ventral posteromedial nucleus of thalamus intersection_of: UBERON:0002945 ! ventral posteromedial nucleus of thalamus intersection_of: RO:0002162 NCBITaxon:9606 ! in taxon Homo sapiens relationship: BFO:0000050 DHBA:10423 ! part of ventral posterior nucleus of thalamus property_value: IAO:0000028 "VPM" xsd:string property_value: skos:prefLabel "ventral posterior medial nucleus ( human dev )" xsd:string [Term] id: DHBA:10428 name: posterior nuclear complex of thalamus synonym: "PoN" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=138322603#structure=10428 xref: http://atlas.brain-map.org/atlas?atlas=138322605#structure=10428 xref: http://atlas.brain-map.org/atlas?atlas=265297126#structure=10428 xref: http://atlas.brain-map.org/atlas?atlas=3#structure=10428 is_a: DHBA:10157 ! gray matter of forebrain is_a: UBERON:0002709 ! posterior nuclear complex of thalamus intersection_of: UBERON:0002709 ! posterior nuclear complex of thalamus intersection_of: RO:0002162 NCBITaxon:9606 ! in taxon Homo sapiens relationship: BFO:0000050 DHBA:10391 ! part of dorsal thalamus property_value: IAO:0000028 "PoN" xsd:string property_value: skos:prefLabel "posterior nuclear complex of thalamus ( human dev )" xsd:string [Term] id: DHBA:10429 name: lateral geniculate nucleus synonym: "LG" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=138322603#structure=10429 xref: http://atlas.brain-map.org/atlas?atlas=138322605#structure=10429 xref: http://atlas.brain-map.org/atlas?atlas=265297126#structure=10429 xref: http://atlas.brain-map.org/atlas?atlas=3#structure=10429 is_a: DHBA:10440 ! posterior nucleus of thalamus is_a: UBERON:0001926 ! lateral geniculate body intersection_of: UBERON:0001926 ! lateral geniculate body intersection_of: RO:0002162 NCBITaxon:9606 ! in taxon Homo sapiens property_value: IAO:0000028 "LG" xsd:string property_value: skos:prefLabel "lateral geniculate nucleus ( human dev )" xsd:string [Term] id: DHBA:10430 name: dorsal lateral geniculate nucleus synonym: "DLG" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=138322603#structure=10430 xref: http://atlas.brain-map.org/atlas?atlas=138322605#structure=10430 xref: http://atlas.brain-map.org/atlas?atlas=265297126#structure=10430 xref: http://atlas.brain-map.org/atlas?atlas=3#structure=10430 is_a: DHBA:10440 ! posterior nucleus of thalamus is_a: UBERON:0002479 ! dorsal lateral geniculate nucleus intersection_of: UBERON:0002479 ! dorsal lateral geniculate nucleus intersection_of: RO:0002162 NCBITaxon:9606 ! in taxon Homo sapiens relationship: BFO:0000050 DHBA:10429 ! part of lateral geniculate nucleus property_value: IAO:0000028 "DLG" xsd:string property_value: skos:prefLabel "dorsal lateral geniculate nucleus ( human dev )" xsd:string [Term] id: DHBA:10431 name: magnocellular layer of DLG synonym: "DLGmc" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=138322603#structure=10431 xref: http://atlas.brain-map.org/atlas?atlas=138322605#structure=10431 xref: http://atlas.brain-map.org/atlas?atlas=265297126#structure=10431 xref: http://atlas.brain-map.org/atlas?atlas=3#structure=10431 is_a: UBERON:0013606 ! magnocellular layer of dorsal nucleus of lateral geniculate body intersection_of: UBERON:0013606 ! magnocellular layer of dorsal nucleus of lateral geniculate body intersection_of: RO:0002162 NCBITaxon:9606 ! in taxon Homo sapiens relationship: BFO:0000050 DHBA:10430 ! part of dorsal lateral geniculate nucleus property_value: IAO:0000028 "DLGmc" xsd:string property_value: skos:prefLabel "magnocellular layer of DLG ( human dev )" xsd:string [Term] id: DHBA:10440 name: posterior nucleus of thalamus synonym: "Po" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=138322603#structure=10440 xref: http://atlas.brain-map.org/atlas?atlas=138322605#structure=10440 xref: http://atlas.brain-map.org/atlas?atlas=265297126#structure=10440 xref: http://atlas.brain-map.org/atlas?atlas=3#structure=10440 is_a: UBERON:0003030 ! posterior nucleus of thalamus intersection_of: UBERON:0003030 ! posterior nucleus of thalamus intersection_of: RO:0002162 NCBITaxon:9606 ! in taxon Homo sapiens relationship: BFO:0000050 DHBA:10428 ! part of posterior nuclear complex of thalamus property_value: IAO:0000028 "Po" xsd:string property_value: skos:prefLabel "posterior nucleus of thalamus ( human dev )" xsd:string [Term] id: DHBA:10451 name: epithalamus synonym: "ETH" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=138322603#structure=10451 xref: http://atlas.brain-map.org/atlas?atlas=138322605#structure=10451 xref: http://atlas.brain-map.org/atlas?atlas=265297126#structure=10451 xref: http://atlas.brain-map.org/atlas?atlas=3#structure=10451 is_a: UBERON:0001899 ! epithalamus intersection_of: UBERON:0001899 ! epithalamus intersection_of: RO:0002162 NCBITaxon:9606 ! in taxon Homo sapiens relationship: BFO:0000050 DHBA:10390 ! part of thalamus property_value: IAO:0000028 "ETH" xsd:string property_value: skos:prefLabel "epithalamus ( human dev )" xsd:string [Term] id: DHBA:10460 name: pineal body synonym: "Pin" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=138322603#structure=10460 xref: http://atlas.brain-map.org/atlas?atlas=138322605#structure=10460 xref: http://atlas.brain-map.org/atlas?atlas=265297126#structure=10460 xref: http://atlas.brain-map.org/atlas?atlas=3#structure=10460 is_a: UBERON:0001905 ! pineal body intersection_of: UBERON:0001905 ! pineal body intersection_of: RO:0002162 NCBITaxon:9606 ! in taxon Homo sapiens relationship: BFO:0000050 DHBA:10451 ! part of epithalamus property_value: IAO:0000028 "Pin" xsd:string property_value: skos:prefLabel "pineal body ( human dev )" xsd:string [Term] id: DHBA:10461 name: ventral thalamus synonym: "VTH" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=138322603#structure=10461 xref: http://atlas.brain-map.org/atlas?atlas=138322605#structure=10461 xref: http://atlas.brain-map.org/atlas?atlas=265297126#structure=10461 xref: http://atlas.brain-map.org/atlas?atlas=3#structure=10461 is_a: UBERON:0001900 ! ventral thalamus intersection_of: UBERON:0001900 ! ventral thalamus intersection_of: RO:0002162 NCBITaxon:9606 ! in taxon Homo sapiens relationship: BFO:0000050 DHBA:10390 ! part of thalamus property_value: IAO:0000028 "VTH" xsd:string property_value: skos:prefLabel "ventral thalamus ( human dev )" xsd:string [Term] id: DHBA:10463 name: zona incerta synonym: "ZI" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=138322603#structure=10463 xref: http://atlas.brain-map.org/atlas?atlas=138322605#structure=10463 xref: http://atlas.brain-map.org/atlas?atlas=265297126#structure=10463 xref: http://atlas.brain-map.org/atlas?atlas=3#structure=10463 is_a: UBERON:0001907 ! zona incerta intersection_of: UBERON:0001907 ! zona incerta intersection_of: RO:0002162 NCBITaxon:9606 ! in taxon Homo sapiens relationship: BFO:0000050 DHBA:10461 ! part of ventral thalamus property_value: IAO:0000028 "ZI" xsd:string property_value: skos:prefLabel "zona incerta ( human dev )" xsd:string [Term] id: DHBA:10465 name: subthalamus synonym: "SubTH" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=138322603#structure=10465 xref: http://atlas.brain-map.org/atlas?atlas=138322605#structure=10465 xref: http://atlas.brain-map.org/atlas?atlas=265297126#structure=10465 xref: http://atlas.brain-map.org/atlas?atlas=3#structure=10465 is_a: BFO:0000004 relationship: BFO:0000050 DHBA:10389 ! part of diencephalon property_value: IAO:0000028 "SubTH" xsd:string property_value: skos:prefLabel "subthalamus ( human dev )" xsd:string [Term] id: DHBA:10466 name: subthalamic nucleus synonym: "STH" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=138322603#structure=10466 xref: http://atlas.brain-map.org/atlas?atlas=138322605#structure=10466 xref: http://atlas.brain-map.org/atlas?atlas=265297126#structure=10466 xref: http://atlas.brain-map.org/atlas?atlas=3#structure=10466 is_a: UBERON:0001906 ! subthalamic nucleus intersection_of: UBERON:0001906 ! subthalamic nucleus intersection_of: RO:0002162 NCBITaxon:9606 ! in taxon Homo sapiens relationship: BFO:0000050 DHBA:10465 ! part of subthalamus property_value: IAO:0000028 "STH" xsd:string property_value: skos:prefLabel "subthalamic nucleus ( human dev )" xsd:string [Term] id: DHBA:10467 name: hypothalamus synonym: "HTH" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=138322603#structure=10467 xref: http://atlas.brain-map.org/atlas?atlas=138322605#structure=10467 xref: http://atlas.brain-map.org/atlas?atlas=265297126#structure=10467 xref: http://atlas.brain-map.org/atlas?atlas=3#structure=10467 is_a: UBERON:0001898 ! hypothalamus intersection_of: UBERON:0001898 ! hypothalamus intersection_of: RO:0002162 NCBITaxon:9606 ! in taxon Homo sapiens relationship: BFO:0000050 DHBA:10389 ! part of diencephalon property_value: IAO:0000028 "HTH" xsd:string property_value: skos:prefLabel "hypothalamus ( human dev )" xsd:string [Term] id: DHBA:10468 name: preoptic region of HTH synonym: "HTHpo" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=138322603#structure=10468 xref: http://atlas.brain-map.org/atlas?atlas=138322605#structure=10468 xref: http://atlas.brain-map.org/atlas?atlas=265297126#structure=10468 xref: http://atlas.brain-map.org/atlas?atlas=3#structure=10468 is_a: BFO:0000004 relationship: BFO:0000050 DHBA:10467 ! part of hypothalamus property_value: IAO:0000028 "HTHpo" xsd:string property_value: skos:prefLabel "preoptic region of HTH ( human dev )" xsd:string [Term] id: DHBA:10469 name: periventricular nucleus, preoptic portion synonym: "PeVpo" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=138322603#structure=10469 xref: http://atlas.brain-map.org/atlas?atlas=138322605#structure=10469 xref: http://atlas.brain-map.org/atlas?atlas=265297126#structure=10469 xref: http://atlas.brain-map.org/atlas?atlas=3#structure=10469 is_a: BFO:0000004 relationship: BFO:0000050 DHBA:10468 ! part of preoptic region of HTH property_value: IAO:0000028 "PeVpo" xsd:string property_value: skos:prefLabel "periventricular nucleus, preoptic portion ( human dev )" xsd:string [Term] id: DHBA:10473 name: supraoptic region of HTH synonym: "HTHso" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=138322603#structure=10473 xref: http://atlas.brain-map.org/atlas?atlas=138322605#structure=10473 xref: http://atlas.brain-map.org/atlas?atlas=265297126#structure=10473 xref: http://atlas.brain-map.org/atlas?atlas=3#structure=10473 is_a: BFO:0000004 relationship: BFO:0000050 DHBA:10467 ! part of hypothalamus property_value: IAO:0000028 "HTHso" xsd:string property_value: skos:prefLabel "supraoptic region of HTH ( human dev )" xsd:string [Term] id: DHBA:10476 name: paraventricular nucleus of hypothalamus synonym: "PV" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=138322603#structure=10476 xref: http://atlas.brain-map.org/atlas?atlas=138322605#structure=10476 xref: http://atlas.brain-map.org/atlas?atlas=265297126#structure=10476 xref: http://atlas.brain-map.org/atlas?atlas=3#structure=10476 is_a: UBERON:0001930 ! paraventricular nucleus of hypothalamus intersection_of: UBERON:0001930 ! paraventricular nucleus of hypothalamus intersection_of: RO:0002162 NCBITaxon:9606 ! in taxon Homo sapiens relationship: BFO:0000050 DHBA:10473 ! part of supraoptic region of HTH property_value: IAO:0000028 "PV" xsd:string property_value: skos:prefLabel "paraventricular nucleus of hypothalamus ( human dev )" xsd:string [Term] id: DHBA:10480 name: suprachiasmatic nucleus synonym: "SCN" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=138322603#structure=10480 xref: http://atlas.brain-map.org/atlas?atlas=138322605#structure=10480 xref: http://atlas.brain-map.org/atlas?atlas=265297126#structure=10480 xref: http://atlas.brain-map.org/atlas?atlas=3#structure=10480 is_a: UBERON:0002034 ! suprachiasmatic nucleus intersection_of: UBERON:0002034 ! suprachiasmatic nucleus intersection_of: RO:0002162 NCBITaxon:9606 ! in taxon Homo sapiens relationship: BFO:0000050 DHBA:10473 ! part of supraoptic region of HTH property_value: IAO:0000028 "SCN" xsd:string property_value: skos:prefLabel "suprachiasmatic nucleus ( human dev )" xsd:string [Term] id: DHBA:10483 name: tuberal region of HTH synonym: "HTHtub" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=138322603#structure=10483 xref: http://atlas.brain-map.org/atlas?atlas=138322605#structure=10483 xref: http://atlas.brain-map.org/atlas?atlas=265297126#structure=10483 xref: http://atlas.brain-map.org/atlas?atlas=3#structure=10483 is_a: BFO:0000004 relationship: BFO:0000050 DHBA:10467 ! part of hypothalamus property_value: IAO:0000028 "HTHtub" xsd:string property_value: skos:prefLabel "tuberal region of HTH ( human dev )" xsd:string [Term] id: DHBA:10492 name: arcuate nucleus of hypothalamus synonym: "Arc" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=138322603#structure=10492 xref: http://atlas.brain-map.org/atlas?atlas=138322605#structure=10492 xref: http://atlas.brain-map.org/atlas?atlas=265297126#structure=10492 xref: http://atlas.brain-map.org/atlas?atlas=3#structure=10492 is_a: UBERON:0001932 ! arcuate nucleus of hypothalamus intersection_of: UBERON:0001932 ! arcuate nucleus of hypothalamus intersection_of: RO:0002162 NCBITaxon:9606 ! in taxon Homo sapiens relationship: BFO:0000050 DHBA:10483 ! part of tuberal region of HTH property_value: IAO:0000028 "Arc" xsd:string property_value: skos:prefLabel "arcuate nucleus of hypothalamus ( human dev )" xsd:string [Term] id: DHBA:10505 name: pituitary body synonym: "Pit" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=138322603#structure=10505 xref: http://atlas.brain-map.org/atlas?atlas=138322605#structure=10505 xref: http://atlas.brain-map.org/atlas?atlas=265297126#structure=10505 xref: http://atlas.brain-map.org/atlas?atlas=3#structure=10505 is_a: UBERON:0000007 ! pituitary gland intersection_of: UBERON:0000007 ! pituitary gland intersection_of: RO:0002162 NCBITaxon:9606 ! in taxon Homo sapiens relationship: BFO:0000050 DHBA:10467 ! part of hypothalamus property_value: IAO:0000028 "Pit" xsd:string property_value: skos:prefLabel "pituitary body ( human dev )" xsd:string [Term] id: DHBA:10506 name: transient structures of forebrain synonym: "FTS" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=138322603#structure=10506 xref: http://atlas.brain-map.org/atlas?atlas=138322605#structure=10506 xref: http://atlas.brain-map.org/atlas?atlas=265297126#structure=10506 xref: http://atlas.brain-map.org/atlas?atlas=3#structure=10506 is_a: BFO:0000004 relationship: BFO:0000050 DHBA:10157 ! part of gray matter of forebrain property_value: IAO:0000028 "FTS" xsd:string property_value: skos:prefLabel "transient structures of forebrain ( human dev )" xsd:string [Term] id: DHBA:10508 name: marginal zone synonym: "MZ" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=138322603#structure=10508 xref: http://atlas.brain-map.org/atlas?atlas=138322605#structure=10508 xref: http://atlas.brain-map.org/atlas?atlas=265297126#structure=10508 xref: http://atlas.brain-map.org/atlas?atlas=3#structure=10508 is_a: UBERON:0002050 ! embryonic structure is_a: UBERON:0010403 ! brain marginal zone intersection_of: UBERON:0010403 ! brain marginal zone intersection_of: RO:0002162 NCBITaxon:9606 ! in taxon Homo sapiens relationship: BFO:0000050 DHBA:10506 ! part of transient structures of forebrain property_value: IAO:0000028 "MZ" xsd:string property_value: skos:prefLabel "marginal zone ( human dev )" xsd:string [Term] id: DHBA:10515 name: cortical plate synonym: "CP" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=138322603#structure=10515 xref: http://atlas.brain-map.org/atlas?atlas=138322605#structure=10515 xref: http://atlas.brain-map.org/atlas?atlas=265297126#structure=10515 xref: http://atlas.brain-map.org/atlas?atlas=3#structure=10515 is_a: UBERON:0005343 ! cortical plate is_a: UBERON:0006598 ! presumptive structure intersection_of: UBERON:0005343 ! cortical plate intersection_of: RO:0002162 NCBITaxon:9606 ! in taxon Homo sapiens relationship: BFO:0000050 DHBA:10506 ! part of transient structures of forebrain property_value: IAO:0000028 "CP" xsd:string property_value: skos:prefLabel "cortical plate ( human dev )" xsd:string [Term] id: DHBA:10522 name: subplate zone synonym: "SP" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=138322603#structure=10522 xref: http://atlas.brain-map.org/atlas?atlas=138322605#structure=10522 xref: http://atlas.brain-map.org/atlas?atlas=265297126#structure=10522 xref: http://atlas.brain-map.org/atlas?atlas=3#structure=10522 is_a: UBERON:0002050 ! embryonic structure is_a: UBERON:0004035 ! cortical subplate intersection_of: UBERON:0004035 ! cortical subplate intersection_of: RO:0002162 NCBITaxon:9606 ! in taxon Homo sapiens relationship: BFO:0000050 DHBA:10506 ! part of transient structures of forebrain property_value: IAO:0000028 "SP" xsd:string property_value: skos:prefLabel "subplate zone ( human dev )" xsd:string [Term] id: DHBA:10542 name: ventricular zone synonym: "VZ" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=138322603#structure=10542 xref: http://atlas.brain-map.org/atlas?atlas=138322605#structure=10542 xref: http://atlas.brain-map.org/atlas?atlas=265297126#structure=10542 xref: http://atlas.brain-map.org/atlas?atlas=3#structure=10542 is_a: UBERON:0003053 ! ventricular zone intersection_of: UBERON:0003053 ! ventricular zone intersection_of: RO:0002162 NCBITaxon:9606 ! in taxon Homo sapiens relationship: BFO:0000050 DHBA:10506 ! part of transient structures of forebrain property_value: IAO:0000028 "VZ" xsd:string property_value: skos:prefLabel "ventricular zone ( human dev )" xsd:string [Term] id: DHBA:10549 name: Ganglionic eminence (VZ in basal nuclei) synonym: "GE" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=138322603#structure=10549 xref: http://atlas.brain-map.org/atlas?atlas=138322605#structure=10549 xref: http://atlas.brain-map.org/atlas?atlas=265297126#structure=10549 xref: http://atlas.brain-map.org/atlas?atlas=3#structure=10549 is_a: UBERON:0004023 ! ganglionic eminence intersection_of: UBERON:0004023 ! ganglionic eminence intersection_of: RO:0002162 NCBITaxon:9606 ! in taxon Homo sapiens relationship: BFO:0000050 DHBA:10542 ! part of ventricular zone property_value: IAO:0000028 "GE" xsd:string property_value: skos:prefLabel "Ganglionic eminence (VZ in basal nuclei) ( human dev )" xsd:string [Term] id: DHBA:10550 name: medial ganglionic eminence synonym: "MGE" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=138322603#structure=10550 xref: http://atlas.brain-map.org/atlas?atlas=138322605#structure=10550 xref: http://atlas.brain-map.org/atlas?atlas=265297126#structure=10550 xref: http://atlas.brain-map.org/atlas?atlas=3#structure=10550 is_a: UBERON:0004024 ! medial ganglionic eminence intersection_of: UBERON:0004024 ! medial ganglionic eminence intersection_of: RO:0002162 NCBITaxon:9606 ! in taxon Homo sapiens relationship: BFO:0000050 DHBA:10549 ! part of Ganglionic eminence (VZ in basal nuclei) property_value: IAO:0000028 "MGE" xsd:string property_value: skos:prefLabel "medial ganglionic eminence ( human dev )" xsd:string [Term] id: DHBA:10551 name: lateral ganglionic eminence synonym: "LGE" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=138322603#structure=10551 xref: http://atlas.brain-map.org/atlas?atlas=138322605#structure=10551 xref: http://atlas.brain-map.org/atlas?atlas=265297126#structure=10551 xref: http://atlas.brain-map.org/atlas?atlas=3#structure=10551 is_a: UBERON:0004025 ! lateral ganglionic eminence intersection_of: UBERON:0004025 ! lateral ganglionic eminence intersection_of: RO:0002162 NCBITaxon:9606 ! in taxon Homo sapiens relationship: BFO:0000050 DHBA:10549 ! part of Ganglionic eminence (VZ in basal nuclei) property_value: IAO:0000028 "LGE" xsd:string property_value: skos:prefLabel "lateral ganglionic eminence ( human dev )" xsd:string [Term] id: DHBA:10552 name: caudal ganglionic eminence synonym: "CGE" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=138322603#structure=10552 xref: http://atlas.brain-map.org/atlas?atlas=138322605#structure=10552 xref: http://atlas.brain-map.org/atlas?atlas=265297126#structure=10552 xref: http://atlas.brain-map.org/atlas?atlas=3#structure=10552 is_a: UBERON:0004026 ! caudal ganglionic eminence intersection_of: UBERON:0004026 ! caudal ganglionic eminence intersection_of: RO:0002162 NCBITaxon:9606 ! in taxon Homo sapiens relationship: BFO:0000050 DHBA:10549 ! part of Ganglionic eminence (VZ in basal nuclei) property_value: IAO:0000028 "CGE" xsd:string property_value: skos:prefLabel "caudal ganglionic eminence ( human dev )" xsd:string [Term] id: DHBA:10557 name: white matter of forebrain synonym: "FWM" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=138322603#structure=10557 xref: http://atlas.brain-map.org/atlas?atlas=138322605#structure=10557 xref: http://atlas.brain-map.org/atlas?atlas=265297126#structure=10557 xref: http://atlas.brain-map.org/atlas?atlas=3#structure=10557 is_a: UBERON:0019261 ! white matter of forebrain intersection_of: UBERON:0019261 ! white matter of forebrain intersection_of: RO:0002162 NCBITaxon:9606 ! in taxon Homo sapiens relationship: BFO:0000050 DHBA:10156 ! part of forebrain (prosencephalon) property_value: IAO:0000028 "FWM" xsd:string property_value: skos:prefLabel "white matter of forebrain ( human dev )" xsd:string [Term] id: DHBA:10558 name: forebrain commissural fiber tracts synonym: "FCFT" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=138322603#structure=10558 xref: http://atlas.brain-map.org/atlas?atlas=138322605#structure=10558 xref: http://atlas.brain-map.org/atlas?atlas=265297126#structure=10558 xref: http://atlas.brain-map.org/atlas?atlas=3#structure=10558 is_a: BFO:0000004 relationship: BFO:0000050 DHBA:10557 ! part of white matter of forebrain property_value: IAO:0000028 "FCFT" xsd:string property_value: skos:prefLabel "forebrain commissural fiber tracts ( human dev )" xsd:string [Term] id: DHBA:10561 name: corpus callosum synonym: "cc" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=138322603#structure=10561 xref: http://atlas.brain-map.org/atlas?atlas=138322605#structure=10561 xref: http://atlas.brain-map.org/atlas?atlas=265297126#structure=10561 xref: http://atlas.brain-map.org/atlas?atlas=3#structure=10561 is_a: UBERON:0002336 ! corpus callosum intersection_of: UBERON:0002336 ! corpus callosum intersection_of: RO:0002162 NCBITaxon:9606 ! in taxon Homo sapiens relationship: BFO:0000050 DHBA:10558 ! part of forebrain commissural fiber tracts property_value: IAO:0000028 "cc" xsd:string property_value: skos:prefLabel "corpus callosum ( human dev )" xsd:string [Term] id: DHBA:10563 name: genu of corpus callosum synonym: "ccg" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=138322603#structure=10563 xref: http://atlas.brain-map.org/atlas?atlas=138322605#structure=10563 xref: http://atlas.brain-map.org/atlas?atlas=265297126#structure=10563 xref: http://atlas.brain-map.org/atlas?atlas=3#structure=10563 is_a: UBERON:0015599 ! genu of corpus callosum intersection_of: UBERON:0015599 ! genu of corpus callosum intersection_of: RO:0002162 NCBITaxon:9606 ! in taxon Homo sapiens relationship: BFO:0000050 DHBA:10561 ! part of corpus callosum property_value: IAO:0000028 "ccg" xsd:string property_value: skos:prefLabel "genu of corpus callosum ( human dev )" xsd:string [Term] id: DHBA:10567 name: posterior commissure synonym: "poc" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=138322603#structure=10567 xref: http://atlas.brain-map.org/atlas?atlas=138322605#structure=10567 xref: http://atlas.brain-map.org/atlas?atlas=265297126#structure=10567 xref: http://atlas.brain-map.org/atlas?atlas=3#structure=10567 is_a: UBERON:0000936 ! posterior commissure intersection_of: UBERON:0000936 ! posterior commissure intersection_of: RO:0002162 NCBITaxon:9606 ! in taxon Homo sapiens relationship: BFO:0000050 DHBA:10650 ! part of white matter of midbrain property_value: IAO:0000028 "poc" xsd:string property_value: skos:prefLabel "posterior commissure ( human dev )" xsd:string [Term] id: DHBA:10568 name: forebrain ipsilateral fiber tracts synonym: "FIFT" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=138322603#structure=10568 xref: http://atlas.brain-map.org/atlas?atlas=138322605#structure=10568 xref: http://atlas.brain-map.org/atlas?atlas=265297126#structure=10568 xref: http://atlas.brain-map.org/atlas?atlas=3#structure=10568 is_a: UBERON:0022247 ! forebrain ipsilateral fiber tracts intersection_of: UBERON:0022247 ! forebrain ipsilateral fiber tracts intersection_of: RO:0002162 NCBITaxon:9606 ! in taxon Homo sapiens relationship: BFO:0000050 DHBA:10557 ! part of white matter of forebrain property_value: IAO:0000028 "FIFT" xsd:string property_value: skos:prefLabel "forebrain ipsilateral fiber tracts ( human dev )" xsd:string [Term] id: DHBA:10570 name: alveus synonym: "alv" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=138322603#structure=10570 xref: http://atlas.brain-map.org/atlas?atlas=138322605#structure=10570 xref: http://atlas.brain-map.org/atlas?atlas=265297126#structure=10570 xref: http://atlas.brain-map.org/atlas?atlas=3#structure=10570 is_a: UBERON:0007639 ! hippocampus alveus is_a: UBERON:0014532 ! white matter lamina of cerebral hemisphere intersection_of: UBERON:0007639 ! hippocampus alveus intersection_of: RO:0002162 NCBITaxon:9606 ! in taxon Homo sapiens relationship: BFO:0000050 DHBA:10568 ! part of forebrain ipsilateral fiber tracts property_value: IAO:0000028 "alv" xsd:string property_value: skos:prefLabel "alveus ( human dev )" xsd:string [Term] id: DHBA:10573 name: external capsule synonym: "extC" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=138322603#structure=10573 xref: http://atlas.brain-map.org/atlas?atlas=138322605#structure=10573 xref: http://atlas.brain-map.org/atlas?atlas=265297126#structure=10573 xref: http://atlas.brain-map.org/atlas?atlas=3#structure=10573 is_a: DHBA:10557 ! white matter of forebrain is_a: UBERON:0004545 ! external capsule of telencephalon intersection_of: UBERON:0004545 ! external capsule of telencephalon intersection_of: RO:0002162 NCBITaxon:9606 ! in taxon Homo sapiens relationship: BFO:0000050 DHBA:10568 ! part of forebrain ipsilateral fiber tracts property_value: IAO:0000028 "extC" xsd:string property_value: skos:prefLabel "external capsule ( human dev )" xsd:string [Term] id: DHBA:10575 name: fimbria synonym: "fim" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=138322603#structure=10575 xref: http://atlas.brain-map.org/atlas?atlas=138322605#structure=10575 xref: http://atlas.brain-map.org/atlas?atlas=265297126#structure=10575 xref: http://atlas.brain-map.org/atlas?atlas=3#structure=10575 is_a: UBERON:0002310 ! hippocampus fimbria intersection_of: UBERON:0002310 ! hippocampus fimbria intersection_of: RO:0002162 NCBITaxon:9606 ! in taxon Homo sapiens relationship: BFO:0000050 DHBA:10568 ! part of forebrain ipsilateral fiber tracts property_value: IAO:0000028 "fim" xsd:string property_value: skos:prefLabel "fimbria ( human dev )" xsd:string [Term] id: DHBA:10576 name: fornix synonym: "fx" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=138322603#structure=10576 xref: http://atlas.brain-map.org/atlas?atlas=138322605#structure=10576 xref: http://atlas.brain-map.org/atlas?atlas=265297126#structure=10576 xref: http://atlas.brain-map.org/atlas?atlas=3#structure=10576 is_a: UBERON:0000052 ! fornix of brain intersection_of: UBERON:0000052 ! fornix of brain intersection_of: RO:0002162 NCBITaxon:9606 ! in taxon Homo sapiens relationship: BFO:0000050 DHBA:10568 ! part of forebrain ipsilateral fiber tracts property_value: IAO:0000028 "fx" xsd:string property_value: skos:prefLabel "fornix ( human dev )" xsd:string [Term] id: DHBA:10589 name: optic tract synonym: "ot" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=138322603#structure=10589 xref: http://atlas.brain-map.org/atlas?atlas=138322605#structure=10589 xref: http://atlas.brain-map.org/atlas?atlas=265297126#structure=10589 xref: http://atlas.brain-map.org/atlas?atlas=3#structure=10589 is_a: UBERON:0001908 ! optic tract intersection_of: UBERON:0001908 ! optic tract intersection_of: RO:0002162 NCBITaxon:9606 ! in taxon Homo sapiens relationship: BFO:0000050 DHBA:10568 ! part of forebrain ipsilateral fiber tracts property_value: IAO:0000028 "ot" xsd:string property_value: skos:prefLabel "optic tract ( human dev )" xsd:string [Term] id: DHBA:10593 name: thalamic fasciculus synonym: "thf" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=138322603#structure=10593 xref: http://atlas.brain-map.org/atlas?atlas=138322605#structure=10593 xref: http://atlas.brain-map.org/atlas?atlas=265297126#structure=10593 xref: http://atlas.brain-map.org/atlas?atlas=3#structure=10593 is_a: UBERON:0022254 ! ventral thalamic fasciculus intersection_of: UBERON:0022254 ! ventral thalamic fasciculus intersection_of: RO:0002162 NCBITaxon:9606 ! in taxon Homo sapiens relationship: BFO:0000050 DHBA:10568 ! part of forebrain ipsilateral fiber tracts property_value: IAO:0000028 "thf" xsd:string property_value: skos:prefLabel "thalamic fasciculus ( human dev )" xsd:string [Term] id: DHBA:10595 name: ventricles of forebrain synonym: "FV" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=138322603#structure=10595 xref: http://atlas.brain-map.org/atlas?atlas=138322605#structure=10595 xref: http://atlas.brain-map.org/atlas?atlas=265297126#structure=10595 xref: http://atlas.brain-map.org/atlas?atlas=3#structure=10595 is_a: UBERON:0006284 ! early prosencephalic vesicle intersection_of: UBERON:0006284 ! early prosencephalic vesicle intersection_of: RO:0002162 NCBITaxon:9606 ! in taxon Homo sapiens relationship: BFO:0000050 DHBA:10156 ! part of forebrain (prosencephalon) property_value: IAO:0000028 "FV" xsd:string property_value: skos:prefLabel "ventricles of forebrain ( human dev )" xsd:string [Term] id: DHBA:10596 name: lateral ventricles synonym: "LV" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=138322603#structure=10596 xref: http://atlas.brain-map.org/atlas?atlas=138322605#structure=10596 xref: http://atlas.brain-map.org/atlas?atlas=265297126#structure=10596 xref: http://atlas.brain-map.org/atlas?atlas=3#structure=10596 is_a: UBERON:0002285 ! telencephalic ventricle intersection_of: UBERON:0002285 ! telencephalic ventricle intersection_of: RO:0002162 NCBITaxon:9606 ! in taxon Homo sapiens relationship: BFO:0000050 DHBA:10595 ! part of ventricles of forebrain property_value: IAO:0000028 "LV" xsd:string property_value: skos:prefLabel "lateral ventricles ( human dev )" xsd:string [Term] id: DHBA:10601 name: choroid plexus of lateral ventricle synonym: "ChoLV" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=138322603#structure=10601 xref: http://atlas.brain-map.org/atlas?atlas=138322605#structure=10601 xref: http://atlas.brain-map.org/atlas?atlas=265297126#structure=10601 xref: http://atlas.brain-map.org/atlas?atlas=3#structure=10601 is_a: UBERON:0002200 ! vasculature of head is_a: UBERON:0002307 ! choroid plexus of lateral ventricle intersection_of: UBERON:0002307 ! choroid plexus of lateral ventricle intersection_of: RO:0002162 NCBITaxon:9606 ! in taxon Homo sapiens relationship: BFO:0000050 DHBA:146034908 ! part of adjoining structures of forebrain ventricles property_value: IAO:0000028 "ChoLV" xsd:string property_value: skos:prefLabel "choroid plexus of lateral ventricle ( human dev )" xsd:string [Term] id: DHBA:10602 name: third ventricle synonym: "3V" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=138322603#structure=10602 xref: http://atlas.brain-map.org/atlas?atlas=138322605#structure=10602 xref: http://atlas.brain-map.org/atlas?atlas=265297126#structure=10602 xref: http://atlas.brain-map.org/atlas?atlas=3#structure=10602 is_a: UBERON:0002286 ! third ventricle intersection_of: UBERON:0002286 ! third ventricle intersection_of: RO:0002162 NCBITaxon:9606 ! in taxon Homo sapiens relationship: BFO:0000050 DHBA:10595 ! part of ventricles of forebrain property_value: IAO:0000028 "3V" xsd:string property_value: skos:prefLabel "third ventricle ( human dev )" xsd:string [Term] id: DHBA:10609 name: surface structures of forebrain synonym: "FSS" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=138322603#structure=10609 xref: http://atlas.brain-map.org/atlas?atlas=138322605#structure=10609 xref: http://atlas.brain-map.org/atlas?atlas=265297126#structure=10609 xref: http://atlas.brain-map.org/atlas?atlas=3#structure=10609 is_a: BFO:0000004 relationship: BFO:0000050 DHBA:10156 ! part of forebrain (prosencephalon) property_value: IAO:0000028 "FSS" xsd:string property_value: skos:prefLabel "surface structures of forebrain ( human dev )" xsd:string [Term] id: DHBA:10610 name: cerebral sulci synonym: "CeS" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=138322603#structure=10610 xref: http://atlas.brain-map.org/atlas?atlas=138322605#structure=10610 xref: http://atlas.brain-map.org/atlas?atlas=265297126#structure=10610 xref: http://atlas.brain-map.org/atlas?atlas=3#structure=10610 is_a: UBERON:0013118 ! sulcus of brain intersection_of: UBERON:0013118 ! sulcus of brain intersection_of: RO:0002162 NCBITaxon:9606 ! in taxon Homo sapiens relationship: BFO:0000050 DHBA:10609 ! part of surface structures of forebrain property_value: IAO:0000028 "CeS" xsd:string property_value: skos:prefLabel "cerebral sulci ( human dev )" xsd:string [Term] id: DHBA:10611 name: primary sulci synonym: "PriS" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=138322603#structure=10611 xref: http://atlas.brain-map.org/atlas?atlas=138322605#structure=10611 xref: http://atlas.brain-map.org/atlas?atlas=265297126#structure=10611 xref: http://atlas.brain-map.org/atlas?atlas=3#structure=10611 is_a: BFO:0000004 relationship: BFO:0000050 DHBA:10610 ! part of cerebral sulci property_value: IAO:0000028 "PriS" xsd:string property_value: skos:prefLabel "primary sulci ( human dev )" xsd:string [Term] id: DHBA:10614 name: central sulcus synonym: "cs" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=138322603#structure=10614 xref: http://atlas.brain-map.org/atlas?atlas=138322605#structure=10614 xref: http://atlas.brain-map.org/atlas?atlas=265297126#structure=10614 xref: http://atlas.brain-map.org/atlas?atlas=3#structure=10614 is_a: DHBA:10610 ! cerebral sulci is_a: UBERON:0002916 ! central sulcus intersection_of: UBERON:0002916 ! central sulcus intersection_of: RO:0002162 NCBITaxon:9606 ! in taxon Homo sapiens relationship: BFO:0000050 DHBA:10611 ! part of primary sulci property_value: IAO:0000028 "cs" xsd:string property_value: skos:prefLabel "central sulcus ( human dev )" xsd:string [Term] id: DHBA:10622 name: longitudinal fissure synonym: "los" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=138322603#structure=10622 xref: http://atlas.brain-map.org/atlas?atlas=138322605#structure=10622 xref: http://atlas.brain-map.org/atlas?atlas=265297126#structure=10622 xref: http://atlas.brain-map.org/atlas?atlas=3#structure=10622 is_a: UBERON:0002921 ! longitudinal fissure intersection_of: UBERON:0002921 ! longitudinal fissure intersection_of: RO:0002162 NCBITaxon:9606 ! in taxon Homo sapiens relationship: BFO:0000050 DHBA:10611 ! part of primary sulci property_value: IAO:0000028 "los" xsd:string property_value: skos:prefLabel "longitudinal fissure ( human dev )" xsd:string [Term] id: DHBA:10644 name: optic chiasm synonym: "ox" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=138322603#structure=10644 xref: http://atlas.brain-map.org/atlas?atlas=138322605#structure=10644 xref: http://atlas.brain-map.org/atlas?atlas=265297126#structure=10644 xref: http://atlas.brain-map.org/atlas?atlas=3#structure=10644 is_a: UBERON:0000959 ! optic chiasma intersection_of: UBERON:0000959 ! optic chiasma intersection_of: RO:0002162 NCBITaxon:9606 ! in taxon Homo sapiens relationship: BFO:0000050 DHBA:10568 ! part of forebrain ipsilateral fiber tracts property_value: IAO:0000028 "ox" xsd:string property_value: skos:prefLabel "optic chiasm ( human dev )" xsd:string [Term] id: DHBA:10648 name: midbrain (mesencephalon) synonym: "M" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=138322603#structure=10648 xref: http://atlas.brain-map.org/atlas?atlas=138322605#structure=10648 xref: http://atlas.brain-map.org/atlas?atlas=265297126#structure=10648 xref: http://atlas.brain-map.org/atlas?atlas=3#structure=10648 is_a: UBERON:0001891 ! midbrain intersection_of: UBERON:0001891 ! midbrain intersection_of: RO:0002162 NCBITaxon:9606 ! in taxon Homo sapiens relationship: BFO:0000050 DHBA:10155 ! part of brain property_value: IAO:0000028 "M" xsd:string property_value: skos:prefLabel "midbrain (mesencephalon) ( human dev )" xsd:string [Term] id: DHBA:10649 name: gray matter of midbrain synonym: "MGM" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=138322603#structure=10649 xref: http://atlas.brain-map.org/atlas?atlas=138322605#structure=10649 xref: http://atlas.brain-map.org/atlas?atlas=265297126#structure=10649 xref: http://atlas.brain-map.org/atlas?atlas=3#structure=10649 is_a: UBERON:0019267 ! gray matter of midbrain intersection_of: UBERON:0019267 ! gray matter of midbrain intersection_of: RO:0002162 NCBITaxon:9606 ! in taxon Homo sapiens relationship: BFO:0000050 DHBA:10648 ! part of midbrain (mesencephalon) property_value: IAO:0000028 "MGM" xsd:string property_value: skos:prefLabel "gray matter of midbrain ( human dev )" xsd:string [Term] id: DHBA:10650 name: white matter of midbrain synonym: "MWM" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=138322603#structure=10650 xref: http://atlas.brain-map.org/atlas?atlas=138322605#structure=10650 xref: http://atlas.brain-map.org/atlas?atlas=265297126#structure=10650 xref: http://atlas.brain-map.org/atlas?atlas=3#structure=10650 is_a: UBERON:0016554 ! white matter of midbrain intersection_of: UBERON:0016554 ! white matter of midbrain intersection_of: RO:0002162 NCBITaxon:9606 ! in taxon Homo sapiens relationship: BFO:0000050 DHBA:10648 ! part of midbrain (mesencephalon) property_value: IAO:0000028 "MWM" xsd:string property_value: skos:prefLabel "white matter of midbrain ( human dev )" xsd:string [Term] id: DHBA:10652 name: surface structures of midbrain synonym: "MSS" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=138322603#structure=10652 xref: http://atlas.brain-map.org/atlas?atlas=138322605#structure=10652 xref: http://atlas.brain-map.org/atlas?atlas=265297126#structure=10652 xref: http://atlas.brain-map.org/atlas?atlas=3#structure=10652 is_a: BFO:0000004 relationship: BFO:0000050 DHBA:10648 ! part of midbrain (mesencephalon) property_value: IAO:0000028 "MSS" xsd:string property_value: skos:prefLabel "surface structures of midbrain ( human dev )" xsd:string [Term] id: DHBA:10653 name: hindbrain (rhombencephalon) synonym: "H" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=138322603#structure=10653 xref: http://atlas.brain-map.org/atlas?atlas=138322605#structure=10653 xref: http://atlas.brain-map.org/atlas?atlas=265297126#structure=10653 xref: http://atlas.brain-map.org/atlas?atlas=3#structure=10653 is_a: UBERON:0002028 ! hindbrain intersection_of: UBERON:0002028 ! hindbrain intersection_of: RO:0002162 NCBITaxon:9606 ! in taxon Homo sapiens relationship: BFO:0000050 DHBA:10155 ! part of brain property_value: IAO:0000028 "H" xsd:string property_value: skos:prefLabel "hindbrain (rhombencephalon) ( human dev )" xsd:string [Term] id: DHBA:10654 name: gray matter of the hindbrain synonym: "HGM" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=138322603#structure=10654 xref: http://atlas.brain-map.org/atlas?atlas=138322605#structure=10654 xref: http://atlas.brain-map.org/atlas?atlas=265297126#structure=10654 xref: http://atlas.brain-map.org/atlas?atlas=3#structure=10654 is_a: UBERON:0019263 ! gray matter of hindbrain intersection_of: UBERON:0019263 ! gray matter of hindbrain intersection_of: RO:0002162 NCBITaxon:9606 ! in taxon Homo sapiens relationship: BFO:0000050 DHBA:10653 ! part of hindbrain (rhombencephalon) property_value: IAO:0000028 "HGM" xsd:string property_value: skos:prefLabel "gray matter of the hindbrain ( human dev )" xsd:string [Term] id: DHBA:10655 name: metencephalon synonym: "Met" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=138322603#structure=10655 xref: http://atlas.brain-map.org/atlas?atlas=138322605#structure=10655 xref: http://atlas.brain-map.org/atlas?atlas=265297126#structure=10655 xref: http://atlas.brain-map.org/atlas?atlas=3#structure=10655 is_a: UBERON:0001895 ! metencephalon is_a: UBERON:0004731 ! neuromere intersection_of: UBERON:0001895 ! metencephalon intersection_of: RO:0002162 NCBITaxon:9606 ! in taxon Homo sapiens relationship: BFO:0000050 DHBA:10654 ! part of gray matter of the hindbrain property_value: IAO:0000028 "Met" xsd:string property_value: skos:prefLabel "metencephalon ( human dev )" xsd:string [Term] id: DHBA:10656 name: cerebellum synonym: "CB" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=138322603#structure=10656 xref: http://atlas.brain-map.org/atlas?atlas=138322605#structure=10656 xref: http://atlas.brain-map.org/atlas?atlas=265297126#structure=10656 xref: http://atlas.brain-map.org/atlas?atlas=3#structure=10656 is_a: UBERON:0002037 ! cerebellum intersection_of: UBERON:0002037 ! cerebellum intersection_of: RO:0002162 NCBITaxon:9606 ! in taxon Homo sapiens relationship: BFO:0000050 DHBA:10655 ! part of metencephalon property_value: IAO:0000028 "CB" xsd:string property_value: skos:prefLabel "cerebellum ( human dev )" xsd:string [Term] id: DHBA:10657 name: cerebellar cortex synonym: "CBC" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=138322603#structure=10657 xref: http://atlas.brain-map.org/atlas?atlas=138322605#structure=10657 xref: http://atlas.brain-map.org/atlas?atlas=265297126#structure=10657 xref: http://atlas.brain-map.org/atlas?atlas=3#structure=10657 is_a: DHBA:10654 ! gray matter of the hindbrain is_a: UBERON:0002129 ! cerebellar cortex intersection_of: UBERON:0002129 ! cerebellar cortex intersection_of: RO:0002162 NCBITaxon:9606 ! in taxon Homo sapiens relationship: BFO:0000050 DHBA:10656 ! part of cerebellum property_value: IAO:0000028 "CBC" xsd:string property_value: skos:prefLabel "cerebellar cortex ( human dev )" xsd:string [Term] id: DHBA:10658 name: cerebellar vermis synonym: "CBV" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=138322603#structure=10658 xref: http://atlas.brain-map.org/atlas?atlas=138322605#structure=10658 xref: http://atlas.brain-map.org/atlas?atlas=265297126#structure=10658 xref: http://atlas.brain-map.org/atlas?atlas=3#structure=10658 is_a: UBERON:0004720 ! cerebellar vermis intersection_of: UBERON:0004720 ! cerebellar vermis intersection_of: RO:0002162 NCBITaxon:9606 ! in taxon Homo sapiens relationship: BFO:0000050 DHBA:10657 ! part of cerebellar cortex property_value: IAO:0000028 "CBV" xsd:string property_value: skos:prefLabel "cerebellar vermis ( human dev )" xsd:string [Term] id: DHBA:10659 name: cerebellar hemisphere synonym: "CBH" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=138322603#structure=10659 xref: http://atlas.brain-map.org/atlas?atlas=138322605#structure=10659 xref: http://atlas.brain-map.org/atlas?atlas=265297126#structure=10659 xref: http://atlas.brain-map.org/atlas?atlas=3#structure=10659 is_a: UBERON:0002245 ! cerebellar hemisphere intersection_of: UBERON:0002245 ! cerebellar hemisphere intersection_of: RO:0002162 NCBITaxon:9606 ! in taxon Homo sapiens relationship: BFO:0000050 DHBA:10657 ! part of cerebellar cortex property_value: IAO:0000028 "CBH" xsd:string property_value: skos:prefLabel "cerebellar hemisphere ( human dev )" xsd:string [Term] id: DHBA:10660 name: cerebellar deep nuclei synonym: "CbDN" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=138322603#structure=10660 xref: http://atlas.brain-map.org/atlas?atlas=138322605#structure=10660 xref: http://atlas.brain-map.org/atlas?atlas=265297126#structure=10660 xref: http://atlas.brain-map.org/atlas?atlas=3#structure=10660 is_a: DHBA:10654 ! gray matter of the hindbrain is_a: UBERON:0002130 ! cerebellar nuclear complex intersection_of: UBERON:0002130 ! cerebellar nuclear complex intersection_of: RO:0002162 NCBITaxon:9606 ! in taxon Homo sapiens relationship: BFO:0000050 DHBA:10656 ! part of cerebellum property_value: IAO:0000028 "CbDN" xsd:string property_value: skos:prefLabel "cerebellar deep nuclei ( human dev )" xsd:string [Term] id: DHBA:10661 name: pons synonym: "Pn" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=138322603#structure=10661 xref: http://atlas.brain-map.org/atlas?atlas=138322605#structure=10661 xref: http://atlas.brain-map.org/atlas?atlas=265297126#structure=10661 xref: http://atlas.brain-map.org/atlas?atlas=3#structure=10661 is_a: UBERON:0000988 ! pons intersection_of: UBERON:0000988 ! pons intersection_of: RO:0002162 NCBITaxon:9606 ! in taxon Homo sapiens relationship: BFO:0000050 DHBA:10655 ! part of metencephalon property_value: IAO:0000028 "Pn" xsd:string property_value: skos:prefLabel "pons ( human dev )" xsd:string [Term] id: DHBA:10662 name: myelencephalon (medulla oblongata) synonym: "Mo" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=138322603#structure=10662 xref: http://atlas.brain-map.org/atlas?atlas=138322605#structure=10662 xref: http://atlas.brain-map.org/atlas?atlas=265297126#structure=10662 xref: http://atlas.brain-map.org/atlas?atlas=3#structure=10662 is_a: UBERON:0004731 ! neuromere is_a: UBERON:0005290 ! myelencephalon intersection_of: UBERON:0005290 ! myelencephalon intersection_of: RO:0002162 NCBITaxon:9606 ! in taxon Homo sapiens relationship: BFO:0000050 DHBA:10654 ! part of gray matter of the hindbrain property_value: IAO:0000028 "Mo" xsd:string property_value: skos:prefLabel "myelencephalon (medulla oblongata) ( human dev )" xsd:string [Term] id: DHBA:10663 name: transient structures of hindbrain synonym: "HTS" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=138322603#structure=10663 xref: http://atlas.brain-map.org/atlas?atlas=138322605#structure=10663 xref: http://atlas.brain-map.org/atlas?atlas=265297126#structure=10663 xref: http://atlas.brain-map.org/atlas?atlas=3#structure=10663 is_a: BFO:0000004 relationship: BFO:0000050 DHBA:10654 ! part of gray matter of the hindbrain property_value: IAO:0000028 "HTS" xsd:string property_value: skos:prefLabel "transient structures of hindbrain ( human dev )" xsd:string [Term] id: DHBA:10664 name: rhombic lip synonym: "RhL" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=138322603#structure=10664 xref: http://atlas.brain-map.org/atlas?atlas=138322605#structure=10664 xref: http://atlas.brain-map.org/atlas?atlas=265297126#structure=10664 xref: http://atlas.brain-map.org/atlas?atlas=3#structure=10664 is_a: UBERON:0006215 ! rhombic lip intersection_of: UBERON:0006215 ! rhombic lip intersection_of: RO:0002162 NCBITaxon:9606 ! in taxon Homo sapiens relationship: BFO:0000050 DHBA:10663 ! part of transient structures of hindbrain property_value: IAO:0000028 "RhL" xsd:string property_value: skos:prefLabel "rhombic lip ( human dev )" xsd:string [Term] id: DHBA:10665 name: upper (rostral) rhombic lip synonym: "URL" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=138322603#structure=10665 xref: http://atlas.brain-map.org/atlas?atlas=138322605#structure=10665 xref: http://atlas.brain-map.org/atlas?atlas=265297126#structure=10665 xref: http://atlas.brain-map.org/atlas?atlas=3#structure=10665 is_a: UBERON:0009841 ! upper rhombic lip intersection_of: UBERON:0009841 ! upper rhombic lip intersection_of: RO:0002162 NCBITaxon:9606 ! in taxon Homo sapiens relationship: BFO:0000050 DHBA:10664 ! part of rhombic lip property_value: IAO:0000028 "URL" xsd:string property_value: skos:prefLabel "upper (rostral) rhombic lip ( human dev )" xsd:string [Term] id: DHBA:10668 name: white matter of hindbrain synonym: "HWM" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=138322603#structure=10668 xref: http://atlas.brain-map.org/atlas?atlas=138322605#structure=10668 xref: http://atlas.brain-map.org/atlas?atlas=265297126#structure=10668 xref: http://atlas.brain-map.org/atlas?atlas=3#structure=10668 is_a: UBERON:0019258 ! white matter of hindbrain intersection_of: UBERON:0019258 ! white matter of hindbrain intersection_of: RO:0002162 NCBITaxon:9606 ! in taxon Homo sapiens relationship: BFO:0000050 DHBA:10653 ! part of hindbrain (rhombencephalon) property_value: IAO:0000028 "HWM" xsd:string property_value: skos:prefLabel "white matter of hindbrain ( human dev )" xsd:string [Term] id: DHBA:10669 name: ventricles of hindbrain synonym: "HV" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=138322603#structure=10669 xref: http://atlas.brain-map.org/atlas?atlas=138322605#structure=10669 xref: http://atlas.brain-map.org/atlas?atlas=265297126#structure=10669 xref: http://atlas.brain-map.org/atlas?atlas=3#structure=10669 is_a: BFO:0000004 relationship: BFO:0000050 DHBA:10653 ! part of hindbrain (rhombencephalon) property_value: IAO:0000028 "HV" xsd:string property_value: skos:prefLabel "ventricles of hindbrain ( human dev )" xsd:string [Term] id: DHBA:10670 name: surface structures of hindbrain synonym: "HSS" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=138322603#structure=10670 xref: http://atlas.brain-map.org/atlas?atlas=138322605#structure=10670 xref: http://atlas.brain-map.org/atlas?atlas=265297126#structure=10670 xref: http://atlas.brain-map.org/atlas?atlas=3#structure=10670 is_a: BFO:0000004 relationship: BFO:0000050 DHBA:10653 ! part of hindbrain (rhombencephalon) property_value: IAO:0000028 "HSS" xsd:string property_value: skos:prefLabel "surface structures of hindbrain ( human dev )" xsd:string [Term] id: DHBA:11326 name: olfactory nerve layer of olfactory bulb synonym: "OBonl" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=138322603#structure=11326 xref: http://atlas.brain-map.org/atlas?atlas=138322605#structure=11326 xref: http://atlas.brain-map.org/atlas?atlas=265297126#structure=11326 xref: http://atlas.brain-map.org/atlas?atlas=3#structure=11326 is_a: UBERON:0005978 ! olfactory bulb outer nerve layer intersection_of: UBERON:0005978 ! olfactory bulb outer nerve layer intersection_of: RO:0002162 NCBITaxon:9606 ! in taxon Homo sapiens relationship: BFO:0000050 DHBA:10307 ! part of olfactory bulb property_value: IAO:0000028 "OBonl" xsd:string property_value: skos:prefLabel "olfactory nerve layer of olfactory bulb ( human dev )" xsd:string [Term] id: DHBA:11327 name: glomerular layer of olfactory bulb synonym: "OBglo" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=138322603#structure=11327 xref: http://atlas.brain-map.org/atlas?atlas=138322605#structure=11327 xref: http://atlas.brain-map.org/atlas?atlas=265297126#structure=11327 xref: http://atlas.brain-map.org/atlas?atlas=3#structure=11327 is_a: UBERON:0005377 ! olfactory bulb glomerular layer intersection_of: UBERON:0005377 ! olfactory bulb glomerular layer intersection_of: RO:0002162 NCBITaxon:9606 ! in taxon Homo sapiens relationship: BFO:0000050 DHBA:10307 ! part of olfactory bulb property_value: IAO:0000028 "OBglo" xsd:string property_value: skos:prefLabel "glomerular layer of olfactory bulb ( human dev )" xsd:string [Term] id: DHBA:11329 name: mitral cell layer of olfactory bulb synonym: "OBmcl" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=138322603#structure=11329 xref: http://atlas.brain-map.org/atlas?atlas=138322605#structure=11329 xref: http://atlas.brain-map.org/atlas?atlas=265297126#structure=11329 xref: http://atlas.brain-map.org/atlas?atlas=3#structure=11329 is_a: UBERON:0004186 ! olfactory bulb mitral cell layer intersection_of: UBERON:0004186 ! olfactory bulb mitral cell layer intersection_of: RO:0002162 NCBITaxon:9606 ! in taxon Homo sapiens relationship: BFO:0000050 DHBA:10307 ! part of olfactory bulb property_value: IAO:0000028 "OBmcl" xsd:string property_value: skos:prefLabel "mitral cell layer of olfactory bulb ( human dev )" xsd:string [Term] id: DHBA:12024 name: forceps minor (frontalis) synonym: "ccg-mi" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=138322603#structure=12024 xref: http://atlas.brain-map.org/atlas?atlas=138322605#structure=12024 xref: http://atlas.brain-map.org/atlas?atlas=265297126#structure=12024 xref: http://atlas.brain-map.org/atlas?atlas=3#structure=12024 is_a: DHBA:10557 ! white matter of forebrain is_a: UBERON:0034678 ! forceps minor of corpus callosum intersection_of: UBERON:0034678 ! forceps minor of corpus callosum intersection_of: RO:0002162 NCBITaxon:9606 ! in taxon Homo sapiens relationship: BFO:0000050 DHBA:10563 ! part of genu of corpus callosum property_value: IAO:0000028 "ccg-mi" xsd:string property_value: skos:prefLabel "forceps minor (frontalis) ( human dev )" xsd:string [Term] id: DHBA:12073 name: olfactory tract synonym: "olt" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=138322603#structure=12073 xref: http://atlas.brain-map.org/atlas?atlas=138322605#structure=12073 xref: http://atlas.brain-map.org/atlas?atlas=265297126#structure=12073 xref: http://atlas.brain-map.org/atlas?atlas=3#structure=12073 is_a: UBERON:0002265 ! olfactory tract intersection_of: UBERON:0002265 ! olfactory tract intersection_of: RO:0002162 NCBITaxon:9606 ! in taxon Homo sapiens relationship: BFO:0000050 DHBA:10568 ! part of forebrain ipsilateral fiber tracts property_value: IAO:0000028 "olt" xsd:string property_value: skos:prefLabel "olfactory tract ( human dev )" xsd:string [Term] id: DHBA:12074 name: olfactory striae synonym: "ost" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=138322603#structure=12074 xref: http://atlas.brain-map.org/atlas?atlas=138322605#structure=12074 xref: http://atlas.brain-map.org/atlas?atlas=265297126#structure=12074 xref: http://atlas.brain-map.org/atlas?atlas=3#structure=12074 is_a: BFO:0000004 relationship: BFO:0000050 DHBA:10568 ! part of forebrain ipsilateral fiber tracts property_value: IAO:0000028 "ost" xsd:string property_value: skos:prefLabel "olfactory striae ( human dev )" xsd:string [Term] id: DHBA:12075 name: lateral olfactory stria synonym: "lost" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=138322603#structure=12075 xref: http://atlas.brain-map.org/atlas?atlas=138322605#structure=12075 xref: http://atlas.brain-map.org/atlas?atlas=265297126#structure=12075 xref: http://atlas.brain-map.org/atlas?atlas=3#structure=12075 is_a: DHBA:12073 ! olfactory tract is_a: UBERON:0001888 ! lateral olfactory stria intersection_of: UBERON:0001888 ! lateral olfactory stria intersection_of: RO:0002162 NCBITaxon:9606 ! in taxon Homo sapiens relationship: BFO:0000050 DHBA:12074 ! part of olfactory striae property_value: IAO:0000028 "lost" xsd:string property_value: skos:prefLabel "lateral olfactory stria ( human dev )" xsd:string [Term] id: DHBA:12101 name: subcommissural organ synonym: "SCO" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=138322603#structure=12101 xref: http://atlas.brain-map.org/atlas?atlas=138322605#structure=12101 xref: http://atlas.brain-map.org/atlas?atlas=265297126#structure=12101 xref: http://atlas.brain-map.org/atlas?atlas=3#structure=12101 is_a: UBERON:0002139 ! subcommissural organ intersection_of: UBERON:0002139 ! subcommissural organ intersection_of: RO:0002162 NCBITaxon:9606 ! in taxon Homo sapiens relationship: BFO:0000050 DHBA:12291 ! part of midbrain tectum property_value: IAO:0000028 "SCO" xsd:string property_value: skos:prefLabel "subcommissural organ ( human dev )" xsd:string [Term] id: DHBA:12104 name: subfornical organ synonym: "SFO" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=138322603#structure=12104 xref: http://atlas.brain-map.org/atlas?atlas=138322605#structure=12104 xref: http://atlas.brain-map.org/atlas?atlas=265297126#structure=12104 xref: http://atlas.brain-map.org/atlas?atlas=3#structure=12104 is_a: UBERON:0002219 ! subfornical organ intersection_of: UBERON:0002219 ! subfornical organ intersection_of: RO:0002162 NCBITaxon:9606 ! in taxon Homo sapiens relationship: BFO:0000050 DHBA:146034908 ! part of adjoining structures of forebrain ventricles property_value: IAO:0000028 "SFO" xsd:string property_value: skos:prefLabel "subfornical organ ( human dev )" xsd:string [Term] id: DHBA:12106 name: organum vasculosum laminae terminalis synonym: "OVLT" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=138322603#structure=12106 xref: http://atlas.brain-map.org/atlas?atlas=138322605#structure=12106 xref: http://atlas.brain-map.org/atlas?atlas=265297126#structure=12106 xref: http://atlas.brain-map.org/atlas?atlas=3#structure=12106 is_a: UBERON:0002689 ! supraoptic crest intersection_of: UBERON:0002689 ! supraoptic crest intersection_of: RO:0002162 NCBITaxon:9606 ! in taxon Homo sapiens relationship: BFO:0000050 DHBA:146034908 ! part of adjoining structures of forebrain ventricles property_value: IAO:0000028 "OVLT" xsd:string property_value: skos:prefLabel "organum vasculosum laminae terminalis ( human dev )" xsd:string [Term] id: DHBA:12112 name: cerebral gyri and lobules synonym: "CeG" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=138322603#structure=12112 xref: http://atlas.brain-map.org/atlas?atlas=138322605#structure=12112 xref: http://atlas.brain-map.org/atlas?atlas=265297126#structure=12112 xref: http://atlas.brain-map.org/atlas?atlas=3#structure=12112 is_a: BFO:0000004 relationship: BFO:0000050 DHBA:10609 ! part of surface structures of forebrain property_value: IAO:0000028 "CeG" xsd:string property_value: skos:prefLabel "cerebral gyri and lobules ( human dev )" xsd:string [Term] id: DHBA:12113 name: frontal lobe synonym: "FroL" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=138322603#structure=12113 xref: http://atlas.brain-map.org/atlas?atlas=138322605#structure=12113 xref: http://atlas.brain-map.org/atlas?atlas=265297126#structure=12113 xref: http://atlas.brain-map.org/atlas?atlas=3#structure=12113 is_a: UBERON:0016525 ! frontal lobe intersection_of: UBERON:0016525 ! frontal lobe intersection_of: RO:0002162 NCBITaxon:9606 ! in taxon Homo sapiens relationship: BFO:0000050 DHBA:12112 ! part of cerebral gyri and lobules property_value: IAO:0000028 "FroL" xsd:string property_value: skos:prefLabel "frontal lobe ( human dev )" xsd:string [Term] id: DHBA:12131 name: parietal lobe synonym: "ParL" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=138322603#structure=12131 xref: http://atlas.brain-map.org/atlas?atlas=138322605#structure=12131 xref: http://atlas.brain-map.org/atlas?atlas=265297126#structure=12131 xref: http://atlas.brain-map.org/atlas?atlas=3#structure=12131 is_a: UBERON:0001872 ! parietal lobe intersection_of: UBERON:0001872 ! parietal lobe intersection_of: RO:0002162 NCBITaxon:9606 ! in taxon Homo sapiens relationship: BFO:0000050 DHBA:12112 ! part of cerebral gyri and lobules property_value: IAO:0000028 "ParL" xsd:string property_value: skos:prefLabel "parietal lobe ( human dev )" xsd:string [Term] id: DHBA:12139 name: temporal lobe synonym: "TemL" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=138322603#structure=12139 xref: http://atlas.brain-map.org/atlas?atlas=138322605#structure=12139 xref: http://atlas.brain-map.org/atlas?atlas=265297126#structure=12139 xref: http://atlas.brain-map.org/atlas?atlas=3#structure=12139 is_a: UBERON:0001871 ! temporal lobe intersection_of: UBERON:0001871 ! temporal lobe intersection_of: RO:0002162 NCBITaxon:9606 ! in taxon Homo sapiens relationship: BFO:0000050 DHBA:12112 ! part of cerebral gyri and lobules property_value: IAO:0000028 "TemL" xsd:string property_value: skos:prefLabel "temporal lobe ( human dev )" xsd:string [Term] id: DHBA:12155 name: limbic lobe synonym: "LimL" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=138322603#structure=12155 xref: http://atlas.brain-map.org/atlas?atlas=138322605#structure=12155 xref: http://atlas.brain-map.org/atlas?atlas=265297126#structure=12155 xref: http://atlas.brain-map.org/atlas?atlas=3#structure=12155 is_a: UBERON:0002600 ! limbic lobe intersection_of: UBERON:0002600 ! limbic lobe intersection_of: RO:0002162 NCBITaxon:9606 ! in taxon Homo sapiens relationship: BFO:0000050 DHBA:12112 ! part of cerebral gyri and lobules property_value: IAO:0000028 "LimL" xsd:string property_value: skos:prefLabel "limbic lobe ( human dev )" xsd:string [Term] id: DHBA:12181 name: pretectal region synonym: "PTR" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=138322603#structure=12181 xref: http://atlas.brain-map.org/atlas?atlas=138322605#structure=12181 xref: http://atlas.brain-map.org/atlas?atlas=265297126#structure=12181 xref: http://atlas.brain-map.org/atlas?atlas=3#structure=12181 is_a: DHBA:10649 ! gray matter of midbrain is_a: UBERON:0001944 ! pretectal region intersection_of: UBERON:0001944 ! pretectal region intersection_of: RO:0002162 NCBITaxon:9606 ! in taxon Homo sapiens relationship: BFO:0000050 DHBA:10649 ! part of gray matter of midbrain property_value: IAO:0000028 "PTR" xsd:string property_value: skos:prefLabel "pretectal region ( human dev )" xsd:string [Term] id: DHBA:12182 name: pretectal nuclear complex synonym: "PTN" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=138322603#structure=12182 xref: http://atlas.brain-map.org/atlas?atlas=138322605#structure=12182 xref: http://atlas.brain-map.org/atlas?atlas=265297126#structure=12182 xref: http://atlas.brain-map.org/atlas?atlas=3#structure=12182 is_a: UBERON:0009661 ! midbrain nucleus is_a: UBERON:0014450 ! pretectal nucleus intersection_of: UBERON:0014450 ! pretectal nucleus intersection_of: RO:0002162 NCBITaxon:9606 ! in taxon Homo sapiens relationship: BFO:0000050 DHBA:12181 ! part of pretectal region property_value: IAO:0000028 "PTN" xsd:string property_value: skos:prefLabel "pretectal nuclear complex ( human dev )" xsd:string [Term] id: DHBA:12195 name: midbrain tegmentum synonym: "MTg" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=138322603#structure=12195 xref: http://atlas.brain-map.org/atlas?atlas=138322605#structure=12195 xref: http://atlas.brain-map.org/atlas?atlas=265297126#structure=12195 xref: http://atlas.brain-map.org/atlas?atlas=3#structure=12195 is_a: UBERON:0001943 ! midbrain tegmentum intersection_of: UBERON:0001943 ! midbrain tegmentum intersection_of: RO:0002162 NCBITaxon:9606 ! in taxon Homo sapiens relationship: BFO:0000050 DHBA:10649 ! part of gray matter of midbrain property_value: IAO:0000028 "MTg" xsd:string property_value: skos:prefLabel "midbrain tegmentum ( human dev )" xsd:string [Term] id: DHBA:12196 name: efferent nuclei of the cranial nerves in the midbrain synonym: "MEN" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=138322603#structure=12196 xref: http://atlas.brain-map.org/atlas?atlas=138322605#structure=12196 xref: http://atlas.brain-map.org/atlas?atlas=265297126#structure=12196 xref: http://atlas.brain-map.org/atlas?atlas=3#structure=12196 is_a: BFO:0000004 relationship: BFO:0000050 DHBA:12195 ! part of midbrain tegmentum property_value: IAO:0000028 "MEN" xsd:string property_value: skos:prefLabel "efferent nuclei of the cranial nerves in the midbrain ( human dev )" xsd:string [Term] id: DHBA:12198 name: oculomotor nucleus synonym: "3N" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=138322603#structure=12198 xref: http://atlas.brain-map.org/atlas?atlas=138322605#structure=12198 xref: http://atlas.brain-map.org/atlas?atlas=265297126#structure=12198 xref: http://atlas.brain-map.org/atlas?atlas=3#structure=12198 is_a: DHBA:10649 ! gray matter of midbrain is_a: UBERON:0001715 ! oculomotor nuclear complex intersection_of: UBERON:0001715 ! oculomotor nuclear complex intersection_of: RO:0002162 NCBITaxon:9606 ! in taxon Homo sapiens relationship: BFO:0000050 DHBA:12196 ! part of efferent nuclei of the cranial nerves in the midbrain property_value: IAO:0000028 "3N" xsd:string property_value: skos:prefLabel "oculomotor nucleus ( human dev )" xsd:string [Term] id: DHBA:12239 name: midbrain reticular formation synonym: "MRF" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=138322603#structure=12239 xref: http://atlas.brain-map.org/atlas?atlas=138322605#structure=12239 xref: http://atlas.brain-map.org/atlas?atlas=265297126#structure=12239 xref: http://atlas.brain-map.org/atlas?atlas=3#structure=12239 is_a: DHBA:10649 ! gray matter of midbrain is_a: UBERON:0002639 ! midbrain reticular formation intersection_of: UBERON:0002639 ! midbrain reticular formation intersection_of: RO:0002162 NCBITaxon:9606 ! in taxon Homo sapiens relationship: BFO:0000050 DHBA:12195 ! part of midbrain tegmentum property_value: IAO:0000028 "MRF" xsd:string property_value: skos:prefLabel "midbrain reticular formation ( human dev )" xsd:string [Term] id: DHBA:12251 name: substantia nigra synonym: "SN" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=138322603#structure=12251 xref: http://atlas.brain-map.org/atlas?atlas=138322605#structure=12251 xref: http://atlas.brain-map.org/atlas?atlas=265297126#structure=12251 xref: http://atlas.brain-map.org/atlas?atlas=3#structure=12251 is_a: UBERON:0002038 ! substantia nigra is_a: UBERON:0006331 ! brainstem nucleus is_a: UBERON:0007414 ! nucleus of midbrain tegmentum intersection_of: UBERON:0002038 ! substantia nigra intersection_of: RO:0002162 NCBITaxon:9606 ! in taxon Homo sapiens relationship: BFO:0000050 DHBA:12195 ! part of midbrain tegmentum property_value: IAO:0000028 "SN" xsd:string property_value: skos:prefLabel "substantia nigra ( human dev )" xsd:string [Term] id: DHBA:12261 name: ventral tegmental area synonym: "VTA" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=138322603#structure=12261 xref: http://atlas.brain-map.org/atlas?atlas=138322605#structure=12261 xref: http://atlas.brain-map.org/atlas?atlas=265297126#structure=12261 xref: http://atlas.brain-map.org/atlas?atlas=3#structure=12261 is_a: UBERON:0002691 ! ventral tegmental area intersection_of: UBERON:0002691 ! ventral tegmental area intersection_of: RO:0002162 NCBITaxon:9606 ! in taxon Homo sapiens relationship: BFO:0000050 DHBA:146034938 ! part of ventral tegmental region of midbrain property_value: IAO:0000028 "VTA" xsd:string property_value: skos:prefLabel "ventral tegmental area ( human dev )" xsd:string [Term] id: DHBA:12277 name: other nuclei in midbrain tegmentum synonym: "XMTg" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=138322603#structure=12277 xref: http://atlas.brain-map.org/atlas?atlas=138322605#structure=12277 xref: http://atlas.brain-map.org/atlas?atlas=265297126#structure=12277 xref: http://atlas.brain-map.org/atlas?atlas=3#structure=12277 is_a: BFO:0000004 relationship: BFO:0000050 DHBA:12195 ! part of midbrain tegmentum property_value: IAO:0000028 "XMTg" xsd:string property_value: skos:prefLabel "other nuclei in midbrain tegmentum ( human dev )" xsd:string [Term] id: DHBA:12289 name: retrorubral field synonym: "RRF" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=138322603#structure=12289 xref: http://atlas.brain-map.org/atlas?atlas=138322605#structure=12289 xref: http://atlas.brain-map.org/atlas?atlas=265297126#structure=12289 xref: http://atlas.brain-map.org/atlas?atlas=3#structure=12289 is_a: UBERON:0011172 ! retrorubral area of midbrain reticular nucleus intersection_of: UBERON:0011172 ! retrorubral area of midbrain reticular nucleus intersection_of: RO:0002162 NCBITaxon:9606 ! in taxon Homo sapiens relationship: BFO:0000050 DHBA:12277 ! part of other nuclei in midbrain tegmentum property_value: IAO:0000028 "RRF" xsd:string property_value: skos:prefLabel "retrorubral field ( human dev )" xsd:string [Term] id: DHBA:12291 name: midbrain tectum synonym: "MTc" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=138322603#structure=12291 xref: http://atlas.brain-map.org/atlas?atlas=138322605#structure=12291 xref: http://atlas.brain-map.org/atlas?atlas=265297126#structure=12291 xref: http://atlas.brain-map.org/atlas?atlas=3#structure=12291 is_a: UBERON:0002314 ! midbrain tectum intersection_of: UBERON:0002314 ! midbrain tectum intersection_of: RO:0002162 NCBITaxon:9606 ! in taxon Homo sapiens relationship: BFO:0000050 DHBA:10649 ! part of gray matter of midbrain property_value: IAO:0000028 "MTc" xsd:string property_value: skos:prefLabel "midbrain tectum ( human dev )" xsd:string [Term] id: DHBA:12314 name: transient structures of midbrain synonym: "MTS" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=138322603#structure=12314 xref: http://atlas.brain-map.org/atlas?atlas=138322605#structure=12314 xref: http://atlas.brain-map.org/atlas?atlas=265297126#structure=12314 xref: http://atlas.brain-map.org/atlas?atlas=3#structure=12314 is_a: BFO:0000004 relationship: BFO:0000050 DHBA:10649 ! part of gray matter of midbrain property_value: IAO:0000028 "MTS" xsd:string property_value: skos:prefLabel "transient structures of midbrain ( human dev )" xsd:string [Term] id: DHBA:12319 name: intermediate (mantle) zone of midbrain synonym: "IZM" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=138322603#structure=12319 xref: http://atlas.brain-map.org/atlas?atlas=138322605#structure=12319 xref: http://atlas.brain-map.org/atlas?atlas=265297126#structure=12319 xref: http://atlas.brain-map.org/atlas?atlas=3#structure=12319 is_a: BFO:0000004 relationship: BFO:0000050 DHBA:12314 ! part of transient structures of midbrain property_value: IAO:0000028 "IZM" xsd:string property_value: skos:prefLabel "intermediate (mantle) zone of midbrain ( human dev )" xsd:string [Term] id: DHBA:12320 name: roof plate of midbrain synonym: "IZMro" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=138322603#structure=12320 xref: http://atlas.brain-map.org/atlas?atlas=138322605#structure=12320 xref: http://atlas.brain-map.org/atlas?atlas=265297126#structure=12320 xref: http://atlas.brain-map.org/atlas?atlas=3#structure=12320 is_a: UBERON:0003299 ! roof plate of midbrain intersection_of: UBERON:0003299 ! roof plate of midbrain intersection_of: RO:0002162 NCBITaxon:9606 ! in taxon Homo sapiens relationship: BFO:0000050 DHBA:12319 ! part of intermediate (mantle) zone of midbrain property_value: IAO:0000028 "IZMro" xsd:string property_value: skos:prefLabel "roof plate of midbrain ( human dev )" xsd:string [Term] id: DHBA:12322 name: basal plate of midbrain synonym: "IZMba" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=138322603#structure=12322 xref: http://atlas.brain-map.org/atlas?atlas=138322605#structure=12322 xref: http://atlas.brain-map.org/atlas?atlas=265297126#structure=12322 xref: http://atlas.brain-map.org/atlas?atlas=3#structure=12322 is_a: DHBA:10649 ! gray matter of midbrain is_a: UBERON:0010285 ! midbrain basal plate intersection_of: UBERON:0010285 ! midbrain basal plate intersection_of: RO:0002162 NCBITaxon:9606 ! in taxon Homo sapiens relationship: BFO:0000050 DHBA:12319 ! part of intermediate (mantle) zone of midbrain property_value: IAO:0000028 "IZMba" xsd:string property_value: skos:prefLabel "basal plate of midbrain ( human dev )" xsd:string [Term] id: DHBA:12325 name: floor plate of midbrain synonym: "IZMfl" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=138322603#structure=12325 xref: http://atlas.brain-map.org/atlas?atlas=138322605#structure=12325 xref: http://atlas.brain-map.org/atlas?atlas=265297126#structure=12325 xref: http://atlas.brain-map.org/atlas?atlas=3#structure=12325 is_a: UBERON:0003307 ! floor plate of midbrain intersection_of: UBERON:0003307 ! floor plate of midbrain intersection_of: RO:0002162 NCBITaxon:9606 ! in taxon Homo sapiens relationship: BFO:0000050 DHBA:12319 ! part of intermediate (mantle) zone of midbrain property_value: IAO:0000028 "IZMfl" xsd:string property_value: skos:prefLabel "floor plate of midbrain ( human dev )" xsd:string [Term] id: DHBA:12366 name: ventral tegmental decussation synonym: "xvtg" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=138322603#structure=12366 xref: http://atlas.brain-map.org/atlas?atlas=138322605#structure=12366 xref: http://atlas.brain-map.org/atlas?atlas=265297126#structure=12366 xref: http://atlas.brain-map.org/atlas?atlas=3#structure=12366 is_a: UBERON:0002615 ! ventral tegmental decussation intersection_of: UBERON:0002615 ! ventral tegmental decussation intersection_of: RO:0002162 NCBITaxon:9606 ! in taxon Homo sapiens relationship: BFO:0000050 DHBA:10650 ! part of white matter of midbrain property_value: IAO:0000028 "xvtg" xsd:string property_value: skos:prefLabel "ventral tegmental decussation ( human dev )" xsd:string [Term] id: DHBA:12376 name: root of oculomotor nerve synonym: "r3" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=138322603#structure=12376 xref: http://atlas.brain-map.org/atlas?atlas=138322605#structure=12376 xref: http://atlas.brain-map.org/atlas?atlas=265297126#structure=12376 xref: http://atlas.brain-map.org/atlas?atlas=3#structure=12376 is_a: UBERON:0002668 ! oculomotor nerve root intersection_of: UBERON:0002668 ! oculomotor nerve root intersection_of: RO:0002162 NCBITaxon:9606 ! in taxon Homo sapiens relationship: BFO:0000050 DHBA:10652 ! part of surface structures of midbrain property_value: IAO:0000028 "r3" xsd:string property_value: skos:prefLabel "root of oculomotor nerve ( human dev )" xsd:string [Term] id: DHBA:12405 name: basilar part of pons synonym: "PnBa" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=138322603#structure=12405 xref: http://atlas.brain-map.org/atlas?atlas=138322605#structure=12405 xref: http://atlas.brain-map.org/atlas?atlas=265297126#structure=12405 xref: http://atlas.brain-map.org/atlas?atlas=3#structure=12405 is_a: UBERON:0002567 ! basal part of pons intersection_of: UBERON:0002567 ! basal part of pons intersection_of: RO:0002162 NCBITaxon:9606 ! in taxon Homo sapiens relationship: BFO:0000050 DHBA:10661 ! part of pons property_value: IAO:0000028 "PnBa" xsd:string property_value: skos:prefLabel "basilar part of pons ( human dev )" xsd:string [Term] id: DHBA:12406 name: pontine nucleus synonym: "PN" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=138322603#structure=12406 xref: http://atlas.brain-map.org/atlas?atlas=138322605#structure=12406 xref: http://atlas.brain-map.org/atlas?atlas=265297126#structure=12406 xref: http://atlas.brain-map.org/atlas?atlas=3#structure=12406 is_a: UBERON:0002151 ! pontine nuclear group intersection_of: UBERON:0002151 ! pontine nuclear group intersection_of: RO:0002162 NCBITaxon:9606 ! in taxon Homo sapiens relationship: BFO:0000050 DHBA:12405 ! part of basilar part of pons property_value: IAO:0000028 "PN" xsd:string property_value: skos:prefLabel "pontine nucleus ( human dev )" xsd:string [Term] id: DHBA:12413 name: peduncular nucleus synonym: "PNped" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=138322603#structure=12413 xref: http://atlas.brain-map.org/atlas?atlas=138322605#structure=12413 xref: http://atlas.brain-map.org/atlas?atlas=265297126#structure=12413 xref: http://atlas.brain-map.org/atlas?atlas=3#structure=12413 is_a: UBERON:0002142 ! pedunculopontine tegmental nucleus is_a: UBERON:0009662 ! hindbrain nucleus intersection_of: UBERON:0002142 ! pedunculopontine tegmental nucleus intersection_of: RO:0002162 NCBITaxon:9606 ! in taxon Homo sapiens relationship: BFO:0000050 DHBA:12406 ! part of pontine nucleus property_value: IAO:0000028 "PNped" xsd:string property_value: skos:prefLabel "peduncular nucleus ( human dev )" xsd:string [Term] id: DHBA:12416 name: pontine tegmentum synonym: "PnTg" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=138322603#structure=12416 xref: http://atlas.brain-map.org/atlas?atlas=138322605#structure=12416 xref: http://atlas.brain-map.org/atlas?atlas=265297126#structure=12416 xref: http://atlas.brain-map.org/atlas?atlas=3#structure=12416 is_a: UBERON:0003023 ! pontine tegmentum intersection_of: UBERON:0003023 ! pontine tegmentum intersection_of: RO:0002162 NCBITaxon:9606 ! in taxon Homo sapiens relationship: BFO:0000050 DHBA:10661 ! part of pons property_value: IAO:0000028 "PnTg" xsd:string property_value: skos:prefLabel "pontine tegmentum ( human dev )" xsd:string [Term] id: DHBA:12417 name: efferent nuclei of cranial nerves in pons synonym: "PnEN" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=138322603#structure=12417 xref: http://atlas.brain-map.org/atlas?atlas=138322605#structure=12417 xref: http://atlas.brain-map.org/atlas?atlas=265297126#structure=12417 xref: http://atlas.brain-map.org/atlas?atlas=3#structure=12417 is_a: BFO:0000004 relationship: BFO:0000050 DHBA:12416 ! part of pontine tegmentum property_value: IAO:0000028 "PnEN" xsd:string property_value: skos:prefLabel "efferent nuclei of cranial nerves in pons ( human dev )" xsd:string [Term] id: DHBA:12420 name: facial nucleus synonym: "7N" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=138322603#structure=12420 xref: http://atlas.brain-map.org/atlas?atlas=138322605#structure=12420 xref: http://atlas.brain-map.org/atlas?atlas=265297126#structure=12420 xref: http://atlas.brain-map.org/atlas?atlas=3#structure=12420 is_a: UBERON:0000127 ! facial nucleus intersection_of: UBERON:0000127 ! facial nucleus intersection_of: RO:0002162 NCBITaxon:9606 ! in taxon Homo sapiens relationship: BFO:0000050 DHBA:12417 ! part of efferent nuclei of cranial nerves in pons property_value: IAO:0000028 "7N" xsd:string property_value: skos:prefLabel "facial nucleus ( human dev )" xsd:string [Term] id: DHBA:12435 name: superior salivatory nucleus synonym: "SuSV" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=138322603#structure=12435 xref: http://atlas.brain-map.org/atlas?atlas=138322605#structure=12435 xref: http://atlas.brain-map.org/atlas?atlas=265297126#structure=12435 xref: http://atlas.brain-map.org/atlas?atlas=3#structure=12435 is_a: UBERON:0002149 ! superior salivatory nucleus intersection_of: UBERON:0002149 ! superior salivatory nucleus intersection_of: RO:0002162 NCBITaxon:9606 ! in taxon Homo sapiens relationship: BFO:0000050 DHBA:12417 ! part of efferent nuclei of cranial nerves in pons property_value: IAO:0000028 "SuSV" xsd:string property_value: skos:prefLabel "superior salivatory nucleus ( human dev )" xsd:string [Term] id: DHBA:12436 name: afferent nuclei of cranial nerves in pons synonym: "PnAN" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=138322603#structure=12436 xref: http://atlas.brain-map.org/atlas?atlas=138322605#structure=12436 xref: http://atlas.brain-map.org/atlas?atlas=265297126#structure=12436 xref: http://atlas.brain-map.org/atlas?atlas=3#structure=12436 is_a: BFO:0000004 relationship: BFO:0000050 DHBA:12416 ! part of pontine tegmentum property_value: IAO:0000028 "PnAN" xsd:string property_value: skos:prefLabel "afferent nuclei of cranial nerves in pons ( human dev )" xsd:string [Term] id: DHBA:12437 name: cochlear nuclei synonym: "8Co" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=138322603#structure=12437 xref: http://atlas.brain-map.org/atlas?atlas=138322605#structure=12437 xref: http://atlas.brain-map.org/atlas?atlas=265297126#structure=12437 xref: http://atlas.brain-map.org/atlas?atlas=3#structure=12437 is_a: DHBA:10654 ! gray matter of the hindbrain is_a: UBERON:0002610 ! cochlear nuclear complex intersection_of: UBERON:0002610 ! cochlear nuclear complex intersection_of: RO:0002162 NCBITaxon:9606 ! in taxon Homo sapiens relationship: BFO:0000050 DHBA:12436 ! part of afferent nuclei of cranial nerves in pons property_value: IAO:0000028 "8Co" xsd:string property_value: skos:prefLabel "cochlear nuclei ( human dev )" xsd:string [Term] id: DHBA:12438 name: dorsal cochlear nucleus synonym: "DCo" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=138322603#structure=12438 xref: http://atlas.brain-map.org/atlas?atlas=138322605#structure=12438 xref: http://atlas.brain-map.org/atlas?atlas=265297126#structure=12438 xref: http://atlas.brain-map.org/atlas?atlas=3#structure=12438 is_a: UBERON:0002829 ! dorsal cochlear nucleus intersection_of: UBERON:0002829 ! dorsal cochlear nucleus intersection_of: RO:0002162 NCBITaxon:9606 ! in taxon Homo sapiens relationship: BFO:0000050 DHBA:12437 ! part of cochlear nuclei property_value: IAO:0000028 "DCo" xsd:string property_value: skos:prefLabel "dorsal cochlear nucleus ( human dev )" xsd:string [Term] id: DHBA:12439 name: ventral cochlear nucleus synonym: "VCo" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=138322603#structure=12439 xref: http://atlas.brain-map.org/atlas?atlas=138322605#structure=12439 xref: http://atlas.brain-map.org/atlas?atlas=265297126#structure=12439 xref: http://atlas.brain-map.org/atlas?atlas=3#structure=12439 is_a: UBERON:0002828 ! ventral cochlear nucleus intersection_of: UBERON:0002828 ! ventral cochlear nucleus intersection_of: RO:0002162 NCBITaxon:9606 ! in taxon Homo sapiens relationship: BFO:0000050 DHBA:12437 ! part of cochlear nuclei property_value: IAO:0000028 "VCo" xsd:string property_value: skos:prefLabel "ventral cochlear nucleus ( human dev )" xsd:string [Term] id: DHBA:12440 name: ventral cochlear nucleus, rostral part synonym: "VCoR" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=138322603#structure=12440 xref: http://atlas.brain-map.org/atlas?atlas=138322605#structure=12440 xref: http://atlas.brain-map.org/atlas?atlas=265297126#structure=12440 xref: http://atlas.brain-map.org/atlas?atlas=3#structure=12440 is_a: UBERON:0002830 ! anteroventral cochlear nucleus intersection_of: UBERON:0002830 ! anteroventral cochlear nucleus intersection_of: RO:0002162 NCBITaxon:9606 ! in taxon Homo sapiens relationship: BFO:0000050 DHBA:12439 ! part of ventral cochlear nucleus property_value: IAO:0000028 "VCoR" xsd:string property_value: skos:prefLabel "ventral cochlear nucleus, rostral part ( human dev )" xsd:string [Term] id: DHBA:12441 name: ventral cochlear nucleus, caudal part synonym: "VCoC" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=138322603#structure=12441 xref: http://atlas.brain-map.org/atlas?atlas=138322605#structure=12441 xref: http://atlas.brain-map.org/atlas?atlas=265297126#structure=12441 xref: http://atlas.brain-map.org/atlas?atlas=3#structure=12441 is_a: UBERON:0002831 ! posteroventral cochlear nucleus intersection_of: UBERON:0002831 ! posteroventral cochlear nucleus intersection_of: RO:0002162 NCBITaxon:9606 ! in taxon Homo sapiens relationship: BFO:0000050 DHBA:12439 ! part of ventral cochlear nucleus property_value: IAO:0000028 "VCoC" xsd:string property_value: skos:prefLabel "ventral cochlear nucleus, caudal part ( human dev )" xsd:string [Term] id: DHBA:12453 name: auditory relay nuclei in pons synonym: "PnAR" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=138322603#structure=12453 xref: http://atlas.brain-map.org/atlas?atlas=138322605#structure=12453 xref: http://atlas.brain-map.org/atlas?atlas=265297126#structure=12453 xref: http://atlas.brain-map.org/atlas?atlas=3#structure=12453 is_a: BFO:0000004 relationship: BFO:0000050 DHBA:12416 ! part of pontine tegmentum property_value: IAO:0000028 "PnAR" xsd:string property_value: skos:prefLabel "auditory relay nuclei in pons ( human dev )" xsd:string [Term] id: DHBA:12462 name: superior olivary complex synonym: "SOC" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=138322603#structure=12462 xref: http://atlas.brain-map.org/atlas?atlas=138322605#structure=12462 xref: http://atlas.brain-map.org/atlas?atlas=265297126#structure=12462 xref: http://atlas.brain-map.org/atlas?atlas=3#structure=12462 is_a: DHBA:10654 ! gray matter of the hindbrain is_a: UBERON:0002128 ! superior olivary complex intersection_of: UBERON:0002128 ! superior olivary complex intersection_of: RO:0002162 NCBITaxon:9606 ! in taxon Homo sapiens relationship: BFO:0000050 DHBA:12453 ! part of auditory relay nuclei in pons property_value: IAO:0000028 "SOC" xsd:string property_value: skos:prefLabel "superior olivary complex ( human dev )" xsd:string [Term] id: DHBA:12471 name: raphe pontis nucleus synonym: "PnRa" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=138322603#structure=12471 xref: http://atlas.brain-map.org/atlas?atlas=138322605#structure=12471 xref: http://atlas.brain-map.org/atlas?atlas=265297126#structure=12471 xref: http://atlas.brain-map.org/atlas?atlas=3#structure=12471 is_a: BFO:0000004 relationship: BFO:0000050 DHBA:12416 ! part of pontine tegmentum property_value: IAO:0000028 "PnRa" xsd:string property_value: skos:prefLabel "raphe pontis nucleus ( human dev )" xsd:string [Term] id: DHBA:12475 name: raphe pontis nucleus synonym: "PRn" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=138322603#structure=12475 xref: http://atlas.brain-map.org/atlas?atlas=138322605#structure=12475 xref: http://atlas.brain-map.org/atlas?atlas=265297126#structure=12475 xref: http://atlas.brain-map.org/atlas?atlas=3#structure=12475 is_a: UBERON:0002047 ! pontine raphe nucleus intersection_of: UBERON:0002047 ! pontine raphe nucleus intersection_of: RO:0002162 NCBITaxon:9606 ! in taxon Homo sapiens relationship: BFO:0000050 DHBA:12471 ! part of raphe pontis nucleus property_value: IAO:0000028 "PRn" xsd:string property_value: skos:prefLabel "raphe pontis nucleus ( human dev )" xsd:string [Term] id: DHBA:12503 name: other nuclei in pontine tegmentum synonym: "XPnTg" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=138322603#structure=12503 xref: http://atlas.brain-map.org/atlas?atlas=138322605#structure=12503 xref: http://atlas.brain-map.org/atlas?atlas=265297126#structure=12503 xref: http://atlas.brain-map.org/atlas?atlas=3#structure=12503 is_a: BFO:0000004 relationship: BFO:0000050 DHBA:12416 ! part of pontine tegmentum property_value: IAO:0000028 "XPnTg" xsd:string property_value: skos:prefLabel "other nuclei in pontine tegmentum ( human dev )" xsd:string [Term] id: DHBA:12531 name: retrotrapezoid nucleus synonym: "RTz" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=138322603#structure=12531 xref: http://atlas.brain-map.org/atlas?atlas=138322605#structure=12531 xref: http://atlas.brain-map.org/atlas?atlas=265297126#structure=12531 xref: http://atlas.brain-map.org/atlas?atlas=3#structure=12531 is_a: UBERON:0009918 ! retrotrapezoid nucleus intersection_of: UBERON:0009918 ! retrotrapezoid nucleus intersection_of: RO:0002162 NCBITaxon:9606 ! in taxon Homo sapiens relationship: BFO:0000050 DHBA:12503 ! part of other nuclei in pontine tegmentum property_value: IAO:0000028 "RTz" xsd:string property_value: skos:prefLabel "retrotrapezoid nucleus ( human dev )" xsd:string [Term] id: DHBA:12538 name: tegmentum of medulla oblongata synonym: "MoTg" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=138322603#structure=12538 xref: http://atlas.brain-map.org/atlas?atlas=138322605#structure=12538 xref: http://atlas.brain-map.org/atlas?atlas=265297126#structure=12538 xref: http://atlas.brain-map.org/atlas?atlas=3#structure=12538 is_a: BFO:0000004 relationship: BFO:0000050 DHBA:10662 ! part of myelencephalon (medulla oblongata) property_value: IAO:0000028 "MoTg" xsd:string property_value: skos:prefLabel "tegmentum of medulla oblongata ( human dev )" xsd:string [Term] id: DHBA:12539 name: efferent nuclei of cranial nerves in the medulla oblongata synonym: "MoEN" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=138322603#structure=12539 xref: http://atlas.brain-map.org/atlas?atlas=138322605#structure=12539 xref: http://atlas.brain-map.org/atlas?atlas=265297126#structure=12539 xref: http://atlas.brain-map.org/atlas?atlas=3#structure=12539 is_a: BFO:0000004 relationship: BFO:0000050 DHBA:12538 ! part of tegmentum of medulla oblongata property_value: IAO:0000028 "MoEN" xsd:string property_value: skos:prefLabel "efferent nuclei of cranial nerves in the medulla oblongata ( human dev )" xsd:string [Term] id: DHBA:12545 name: hypoglossal nucleus synonym: "12N" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=138322603#structure=12545 xref: http://atlas.brain-map.org/atlas?atlas=138322605#structure=12545 xref: http://atlas.brain-map.org/atlas?atlas=265297126#structure=12545 xref: http://atlas.brain-map.org/atlas?atlas=3#structure=12545 is_a: UBERON:0002871 ! hypoglossal nucleus intersection_of: UBERON:0002871 ! hypoglossal nucleus intersection_of: RO:0002162 NCBITaxon:9606 ! in taxon Homo sapiens relationship: BFO:0000050 DHBA:12539 ! part of efferent nuclei of cranial nerves in the medulla oblongata property_value: IAO:0000028 "12N" xsd:string property_value: skos:prefLabel "hypoglossal nucleus ( human dev )" xsd:string [Term] id: DHBA:12595 name: precerebellar nuclei synonym: "PrCbN" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=138322603#structure=12595 xref: http://atlas.brain-map.org/atlas?atlas=138322605#structure=12595 xref: http://atlas.brain-map.org/atlas?atlas=265297126#structure=12595 xref: http://atlas.brain-map.org/atlas?atlas=3#structure=12595 is_a: BFO:0000004 relationship: BFO:0000050 DHBA:12538 ! part of tegmentum of medulla oblongata property_value: IAO:0000028 "PrCbN" xsd:string property_value: skos:prefLabel "precerebellar nuclei ( human dev )" xsd:string [Term] id: DHBA:12613 name: interpositus nucleus synonym: "IPo" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=138322603#structure=12613 xref: http://atlas.brain-map.org/atlas?atlas=138322605#structure=12613 xref: http://atlas.brain-map.org/atlas?atlas=265297126#structure=12613 xref: http://atlas.brain-map.org/atlas?atlas=3#structure=12613 is_a: UBERON:0004073 ! cerebellum interpositus nucleus intersection_of: UBERON:0004073 ! cerebellum interpositus nucleus intersection_of: RO:0002162 NCBITaxon:9606 ! in taxon Homo sapiens relationship: BFO:0000050 DHBA:12595 ! part of precerebellar nuclei property_value: IAO:0000028 "IPo" xsd:string property_value: skos:prefLabel "interpositus nucleus ( human dev )" xsd:string [Term] id: DHBA:12664 name: hindbrain neuromeres synonym: "HNM" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=138322603#structure=12664 xref: http://atlas.brain-map.org/atlas?atlas=138322605#structure=12664 xref: http://atlas.brain-map.org/atlas?atlas=265297126#structure=12664 xref: http://atlas.brain-map.org/atlas?atlas=3#structure=12664 is_a: UBERON:0001892 ! rhombomere is_a: UBERON:0004733 ! segmental subdivision of hindbrain intersection_of: UBERON:0001892 ! rhombomere intersection_of: RO:0002162 NCBITaxon:9606 ! in taxon Homo sapiens relationship: BFO:0000050 DHBA:10663 ! part of transient structures of hindbrain property_value: IAO:0000028 "HNM" xsd:string property_value: skos:prefLabel "hindbrain neuromeres ( human dev )" xsd:string [Term] id: DHBA:12666 name: rhombomere A synonym: "RhA" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=138322603#structure=12666 xref: http://atlas.brain-map.org/atlas?atlas=138322605#structure=12666 xref: http://atlas.brain-map.org/atlas?atlas=265297126#structure=12666 xref: http://atlas.brain-map.org/atlas?atlas=3#structure=12666 is_a: BFO:0000004 relationship: BFO:0000050 DHBA:12664 ! part of hindbrain neuromeres property_value: IAO:0000028 "RhA" xsd:string property_value: skos:prefLabel "rhombomere A ( human dev )" xsd:string [Term] id: DHBA:12667 name: rhombomere 1 synonym: "Rh1" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=138322603#structure=12667 xref: http://atlas.brain-map.org/atlas?atlas=138322605#structure=12667 xref: http://atlas.brain-map.org/atlas?atlas=265297126#structure=12667 xref: http://atlas.brain-map.org/atlas?atlas=3#structure=12667 is_a: DHBA:12664 ! hindbrain neuromeres is_a: UBERON:0005499 ! rhombomere 1 intersection_of: UBERON:0005499 ! rhombomere 1 intersection_of: RO:0002162 NCBITaxon:9606 ! in taxon Homo sapiens relationship: BFO:0000050 DHBA:12666 ! part of rhombomere A property_value: IAO:0000028 "Rh1" xsd:string property_value: skos:prefLabel "rhombomere 1 ( human dev )" xsd:string [Term] id: DHBA:12682 name: intermediate (mantle) zone of hindbrain synonym: "IZH" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=138322603#structure=12682 xref: http://atlas.brain-map.org/atlas?atlas=138322605#structure=12682 xref: http://atlas.brain-map.org/atlas?atlas=265297126#structure=12682 xref: http://atlas.brain-map.org/atlas?atlas=3#structure=12682 is_a: UBERON:0002050 ! embryonic structure is_a: UBERON:0034994 ! hindbrain cortical intermediate zone intersection_of: UBERON:0034994 ! hindbrain cortical intermediate zone intersection_of: RO:0002162 NCBITaxon:9606 ! in taxon Homo sapiens relationship: BFO:0000050 DHBA:10663 ! part of transient structures of hindbrain property_value: IAO:0000028 "IZH" xsd:string property_value: skos:prefLabel "intermediate (mantle) zone of hindbrain ( human dev )" xsd:string [Term] id: DHBA:12694 name: marginal zone of hindbrain synonym: "MZH" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=138322603#structure=12694 xref: http://atlas.brain-map.org/atlas?atlas=138322605#structure=12694 xref: http://atlas.brain-map.org/atlas?atlas=265297126#structure=12694 xref: http://atlas.brain-map.org/atlas?atlas=3#structure=12694 is_a: UBERON:0034709 ! hindbrain marginal layer intersection_of: UBERON:0034709 ! hindbrain marginal layer intersection_of: RO:0002162 NCBITaxon:9606 ! in taxon Homo sapiens relationship: BFO:0000050 DHBA:10663 ! part of transient structures of hindbrain property_value: IAO:0000028 "MZH" xsd:string property_value: skos:prefLabel "marginal zone of hindbrain ( human dev )" xsd:string [Term] id: DHBA:12695 name: marginal zone of cerebellum synonym: "MZCB" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=138322603#structure=12695 xref: http://atlas.brain-map.org/atlas?atlas=138322605#structure=12695 xref: http://atlas.brain-map.org/atlas?atlas=265297126#structure=12695 xref: http://atlas.brain-map.org/atlas?atlas=3#structure=12695 is_a: DHBA:12694 ! marginal zone of hindbrain is_a: UBERON:0034708 ! cerebellum marginal layer intersection_of: UBERON:0034708 ! cerebellum marginal layer intersection_of: RO:0002162 NCBITaxon:9606 ! in taxon Homo sapiens relationship: BFO:0000050 DHBA:12694 ! part of marginal zone of hindbrain property_value: IAO:0000028 "MZCB" xsd:string property_value: skos:prefLabel "marginal zone of cerebellum ( human dev )" xsd:string [Term] id: DHBA:12698 name: cerebellar plate synonym: "CbP" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=138322603#structure=12698 xref: http://atlas.brain-map.org/atlas?atlas=138322605#structure=12698 xref: http://atlas.brain-map.org/atlas?atlas=265297126#structure=12698 xref: http://atlas.brain-map.org/atlas?atlas=3#structure=12698 is_a: UBERON:0004008 ! cerebellar plate intersection_of: UBERON:0004008 ! cerebellar plate intersection_of: RO:0002162 NCBITaxon:9606 ! in taxon Homo sapiens relationship: BFO:0000050 DHBA:10663 ! part of transient structures of hindbrain property_value: IAO:0000028 "CbP" xsd:string property_value: skos:prefLabel "cerebellar plate ( human dev )" xsd:string [Term] id: DHBA:12768 name: middle cerebellar peduncle synonym: "mcp" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=138322603#structure=12768 xref: http://atlas.brain-map.org/atlas?atlas=138322605#structure=12768 xref: http://atlas.brain-map.org/atlas?atlas=265297126#structure=12768 xref: http://atlas.brain-map.org/atlas?atlas=3#structure=12768 is_a: DHBA:10668 ! white matter of hindbrain is_a: UBERON:0002152 ! middle cerebellar peduncle intersection_of: UBERON:0002152 ! middle cerebellar peduncle intersection_of: RO:0002162 NCBITaxon:9606 ! in taxon Homo sapiens relationship: BFO:0000050 DHBA:10668 ! part of white matter of hindbrain property_value: IAO:0000028 "mcp" xsd:string property_value: skos:prefLabel "middle cerebellar peduncle ( human dev )" xsd:string [Term] id: DHBA:12773 name: pyramidal tract synonym: "py" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=138322603#structure=12773 xref: http://atlas.brain-map.org/atlas?atlas=138322605#structure=12773 xref: http://atlas.brain-map.org/atlas?atlas=265297126#structure=12773 xref: http://atlas.brain-map.org/atlas?atlas=3#structure=12773 is_a: BFO:0000004 relationship: BFO:0000050 DHBA:10668 ! part of white matter of hindbrain property_value: IAO:0000028 "py" xsd:string property_value: skos:prefLabel "pyramidal tract ( human dev )" xsd:string [Term] id: DHBA:12776 name: corticospinal tract synonym: "csp-h" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=138322603#structure=12776 xref: http://atlas.brain-map.org/atlas?atlas=138322605#structure=12776 xref: http://atlas.brain-map.org/atlas?atlas=265297126#structure=12776 xref: http://atlas.brain-map.org/atlas?atlas=3#structure=12776 is_a: UBERON:0002707 ! corticospinal tract is_a: UBERON:0007702 ! tract of brain intersection_of: UBERON:0002707 ! corticospinal tract intersection_of: RO:0002162 NCBITaxon:9606 ! in taxon Homo sapiens relationship: BFO:0000050 DHBA:12773 ! part of pyramidal tract property_value: IAO:0000028 "csp-h" xsd:string property_value: skos:prefLabel "corticospinal tract ( human dev )" xsd:string [Term] id: DHBA:12782 name: rubrospinal tract synonym: "rusp" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=138322603#structure=12782 xref: http://atlas.brain-map.org/atlas?atlas=138322605#structure=12782 xref: http://atlas.brain-map.org/atlas?atlas=265297126#structure=12782 xref: http://atlas.brain-map.org/atlas?atlas=3#structure=12782 is_a: UBERON:0002714 ! rubrospinal tract intersection_of: UBERON:0002714 ! rubrospinal tract intersection_of: RO:0002162 NCBITaxon:9606 ! in taxon Homo sapiens relationship: BFO:0000050 DHBA:10668 ! part of white matter of hindbrain property_value: IAO:0000028 "rusp" xsd:string property_value: skos:prefLabel "rubrospinal tract ( human dev )" xsd:string [Term] id: DHBA:12805 name: fourth ventricle synonym: "4V" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=138322603#structure=12805 xref: http://atlas.brain-map.org/atlas?atlas=138322605#structure=12805 xref: http://atlas.brain-map.org/atlas?atlas=265297126#structure=12805 xref: http://atlas.brain-map.org/atlas?atlas=3#structure=12805 is_a: UBERON:0002422 ! fourth ventricle intersection_of: UBERON:0002422 ! fourth ventricle intersection_of: RO:0002162 NCBITaxon:9606 ! in taxon Homo sapiens relationship: BFO:0000050 DHBA:10669 ! part of ventricles of hindbrain property_value: IAO:0000028 "4V" xsd:string property_value: skos:prefLabel "fourth ventricle ( human dev )" xsd:string [Term] id: DHBA:12807 name: area postrema synonym: "AP" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=138322603#structure=12807 xref: http://atlas.brain-map.org/atlas?atlas=138322605#structure=12807 xref: http://atlas.brain-map.org/atlas?atlas=265297126#structure=12807 xref: http://atlas.brain-map.org/atlas?atlas=3#structure=12807 is_a: UBERON:0002162 ! area postrema intersection_of: UBERON:0002162 ! area postrema intersection_of: RO:0002162 NCBITaxon:9606 ! in taxon Homo sapiens relationship: BFO:0000050 DHBA:146035012 ! part of adjoining structures of fourth ventricle property_value: IAO:0000028 "AP" xsd:string property_value: skos:prefLabel "area postrema ( human dev )" xsd:string [Term] id: DHBA:12808 name: choroid plexus of the fourth ventricle synonym: "Cho4V" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=138322603#structure=12808 xref: http://atlas.brain-map.org/atlas?atlas=138322605#structure=12808 xref: http://atlas.brain-map.org/atlas?atlas=265297126#structure=12808 xref: http://atlas.brain-map.org/atlas?atlas=3#structure=12808 is_a: UBERON:0002200 ! vasculature of head is_a: UBERON:0002290 ! choroid plexus of fourth ventricle intersection_of: UBERON:0002290 ! choroid plexus of fourth ventricle intersection_of: RO:0002162 NCBITaxon:9606 ! in taxon Homo sapiens relationship: BFO:0000050 DHBA:146035012 ! part of adjoining structures of fourth ventricle property_value: IAO:0000028 "Cho4V" xsd:string property_value: skos:prefLabel "choroid plexus of the fourth ventricle ( human dev )" xsd:string [Term] id: DHBA:12819 name: locus coeruleus synonym: "LC" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=138322603#structure=12819 xref: http://atlas.brain-map.org/atlas?atlas=138322605#structure=12819 xref: http://atlas.brain-map.org/atlas?atlas=265297126#structure=12819 xref: http://atlas.brain-map.org/atlas?atlas=3#structure=12819 is_a: UBERON:0002148 ! locus ceruleus intersection_of: UBERON:0002148 ! locus ceruleus intersection_of: RO:0002162 NCBITaxon:9606 ! in taxon Homo sapiens relationship: BFO:0000050 DHBA:146035012 ! part of adjoining structures of fourth ventricle property_value: IAO:0000028 "LC" xsd:string property_value: skos:prefLabel "locus coeruleus ( human dev )" xsd:string [Term] id: DHBA:12827 name: surface structures of cerebellum synonym: "CbSS" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=138322603#structure=12827 xref: http://atlas.brain-map.org/atlas?atlas=138322605#structure=12827 xref: http://atlas.brain-map.org/atlas?atlas=265297126#structure=12827 xref: http://atlas.brain-map.org/atlas?atlas=3#structure=12827 is_a: BFO:0000004 relationship: BFO:0000050 DHBA:10670 ! part of surface structures of hindbrain property_value: IAO:0000028 "CbSS" xsd:string property_value: skos:prefLabel "surface structures of cerebellum ( human dev )" xsd:string [Term] id: DHBA:12828 name: cerebellar fissures synonym: "cbf" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=138322603#structure=12828 xref: http://atlas.brain-map.org/atlas?atlas=138322605#structure=12828 xref: http://atlas.brain-map.org/atlas?atlas=265297126#structure=12828 xref: http://atlas.brain-map.org/atlas?atlas=3#structure=12828 is_a: UBERON:0003980 ! cerebellum fissure intersection_of: UBERON:0003980 ! cerebellum fissure intersection_of: RO:0002162 NCBITaxon:9606 ! in taxon Homo sapiens relationship: BFO:0000050 DHBA:12827 ! part of surface structures of cerebellum property_value: IAO:0000028 "cbf" xsd:string property_value: skos:prefLabel "cerebellar fissures ( human dev )" xsd:string [Term] id: DHBA:12837 name: cerebellar lobes and lobules synonym: "CBLL" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=138322603#structure=12837 xref: http://atlas.brain-map.org/atlas?atlas=138322605#structure=12837 xref: http://atlas.brain-map.org/atlas?atlas=265297126#structure=12837 xref: http://atlas.brain-map.org/atlas?atlas=3#structure=12837 is_a: BFO:0000004 relationship: BFO:0000050 DHBA:12827 ! part of surface structures of cerebellum property_value: IAO:0000028 "CBLL" xsd:string property_value: skos:prefLabel "cerebellar lobes and lobules ( human dev )" xsd:string [Term] id: DHBA:12852 name: flocculonodular lobe synonym: "FNCb" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=138322603#structure=12852 xref: http://atlas.brain-map.org/atlas?atlas=138322605#structure=12852 xref: http://atlas.brain-map.org/atlas?atlas=265297126#structure=12852 xref: http://atlas.brain-map.org/atlas?atlas=3#structure=12852 is_a: UBERON:0003012 ! flocculonodular lobe intersection_of: UBERON:0003012 ! flocculonodular lobe intersection_of: RO:0002162 NCBITaxon:9606 ! in taxon Homo sapiens relationship: BFO:0000050 DHBA:12837 ! part of cerebellar lobes and lobules property_value: IAO:0000028 "FNCb" xsd:string property_value: skos:prefLabel "flocculonodular lobe ( human dev )" xsd:string [Term] id: DHBA:12856 name: surface structures of pons synonym: "PnSS" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=138322603#structure=12856 xref: http://atlas.brain-map.org/atlas?atlas=138322605#structure=12856 xref: http://atlas.brain-map.org/atlas?atlas=265297126#structure=12856 xref: http://atlas.brain-map.org/atlas?atlas=3#structure=12856 is_a: BFO:0000004 relationship: BFO:0000050 DHBA:10670 ! part of surface structures of hindbrain property_value: IAO:0000028 "PnSS" xsd:string property_value: skos:prefLabel "surface structures of pons ( human dev )" xsd:string [Term] id: DHBA:12862 name: root of facial nerve synonym: "r7" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=138322603#structure=12862 xref: http://atlas.brain-map.org/atlas?atlas=138322605#structure=12862 xref: http://atlas.brain-map.org/atlas?atlas=265297126#structure=12862 xref: http://atlas.brain-map.org/atlas?atlas=3#structure=12862 is_a: UBERON:0004674 ! facial nerve root intersection_of: UBERON:0004674 ! facial nerve root intersection_of: RO:0002162 NCBITaxon:9606 ! in taxon Homo sapiens relationship: BFO:0000050 DHBA:12856 ! part of surface structures of pons property_value: IAO:0000028 "r7" xsd:string property_value: skos:prefLabel "root of facial nerve ( human dev )" xsd:string [Term] id: DHBA:12865 name: root of trigeminal nerve synonym: "r5" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=138322603#structure=12865 xref: http://atlas.brain-map.org/atlas?atlas=138322605#structure=12865 xref: http://atlas.brain-map.org/atlas?atlas=265297126#structure=12865 xref: http://atlas.brain-map.org/atlas?atlas=3#structure=12865 is_a: UBERON:0004673 ! trigeminal nerve root intersection_of: UBERON:0004673 ! trigeminal nerve root intersection_of: RO:0002162 NCBITaxon:9606 ! in taxon Homo sapiens relationship: BFO:0000050 DHBA:12856 ! part of surface structures of pons property_value: IAO:0000028 "r5" xsd:string property_value: skos:prefLabel "root of trigeminal nerve ( human dev )" xsd:string [Term] id: DHBA:12868 name: root of vestibulocochlear nerve synonym: "r8" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=138322603#structure=12868 xref: http://atlas.brain-map.org/atlas?atlas=138322605#structure=12868 xref: http://atlas.brain-map.org/atlas?atlas=265297126#structure=12868 xref: http://atlas.brain-map.org/atlas?atlas=3#structure=12868 is_a: UBERON:0002731 ! vestibulocochlear nerve root intersection_of: UBERON:0002731 ! vestibulocochlear nerve root intersection_of: RO:0002162 NCBITaxon:9606 ! in taxon Homo sapiens relationship: BFO:0000050 DHBA:12856 ! part of surface structures of pons property_value: IAO:0000028 "r8" xsd:string property_value: skos:prefLabel "root of vestibulocochlear nerve ( human dev )" xsd:string [Term] id: DHBA:12872 name: surface structures of medulla synonym: "MOSS" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=138322603#structure=12872 xref: http://atlas.brain-map.org/atlas?atlas=138322605#structure=12872 xref: http://atlas.brain-map.org/atlas?atlas=265297126#structure=12872 xref: http://atlas.brain-map.org/atlas?atlas=3#structure=12872 is_a: BFO:0000004 relationship: BFO:0000050 DHBA:10670 ! part of surface structures of hindbrain property_value: IAO:0000028 "MOSS" xsd:string property_value: skos:prefLabel "surface structures of medulla ( human dev )" xsd:string [Term] id: DHBA:12883 name: root of accessory nerve synonym: "r11" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=138322603#structure=12883 xref: http://atlas.brain-map.org/atlas?atlas=138322605#structure=12883 xref: http://atlas.brain-map.org/atlas?atlas=265297126#structure=12883 xref: http://atlas.brain-map.org/atlas?atlas=3#structure=12883 is_a: UBERON:0011215 ! central nervous system cell part cluster is_a: UBERON:0014615 ! accessory nerve root intersection_of: UBERON:0014615 ! accessory nerve root intersection_of: RO:0002162 NCBITaxon:9606 ! in taxon Homo sapiens relationship: BFO:0000050 DHBA:12872 ! part of surface structures of medulla property_value: IAO:0000028 "r11" xsd:string property_value: skos:prefLabel "root of accessory nerve ( human dev )" xsd:string [Term] id: DHBA:12886 name: root of hypoglossal nerve synonym: "r12" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=138322603#structure=12886 xref: http://atlas.brain-map.org/atlas?atlas=138322605#structure=12886 xref: http://atlas.brain-map.org/atlas?atlas=265297126#structure=12886 xref: http://atlas.brain-map.org/atlas?atlas=3#structure=12886 is_a: UBERON:0004675 ! hypoglossal nerve root intersection_of: UBERON:0004675 ! hypoglossal nerve root intersection_of: RO:0002162 NCBITaxon:9606 ! in taxon Homo sapiens relationship: BFO:0000050 DHBA:12872 ! part of surface structures of medulla property_value: IAO:0000028 "r12" xsd:string property_value: skos:prefLabel "root of hypoglossal nerve ( human dev )" xsd:string [Term] id: DHBA:12887 name: root of glossopharyngeal nerve synonym: "r9" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=138322603#structure=12887 xref: http://atlas.brain-map.org/atlas?atlas=138322605#structure=12887 xref: http://atlas.brain-map.org/atlas?atlas=265297126#structure=12887 xref: http://atlas.brain-map.org/atlas?atlas=3#structure=12887 is_a: UBERON:0019310 ! glossopharyngeal nerve root intersection_of: UBERON:0019310 ! glossopharyngeal nerve root intersection_of: RO:0002162 NCBITaxon:9606 ! in taxon Homo sapiens relationship: BFO:0000050 DHBA:12872 ! part of surface structures of medulla property_value: IAO:0000028 "r9" xsd:string property_value: skos:prefLabel "root of glossopharyngeal nerve ( human dev )" xsd:string [Term] id: DHBA:12888 name: root of vagus nerve synonym: "r10" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=138322603#structure=12888 xref: http://atlas.brain-map.org/atlas?atlas=138322605#structure=12888 xref: http://atlas.brain-map.org/atlas?atlas=265297126#structure=12888 xref: http://atlas.brain-map.org/atlas?atlas=3#structure=12888 is_a: UBERON:0006843 ! root of cranial nerve is_a: UBERON:0011213 ! root of vagus nerve intersection_of: UBERON:0011213 ! root of vagus nerve intersection_of: RO:0002162 NCBITaxon:9606 ! in taxon Homo sapiens relationship: BFO:0000050 DHBA:12872 ! part of surface structures of medulla property_value: IAO:0000028 "r10" xsd:string property_value: skos:prefLabel "root of vagus nerve ( human dev )" xsd:string [Term] id: DHBA:12890 name: spinal cord synonym: "SpC" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=138322603#structure=12890 xref: http://atlas.brain-map.org/atlas?atlas=138322605#structure=12890 xref: http://atlas.brain-map.org/atlas?atlas=265297126#structure=12890 xref: http://atlas.brain-map.org/atlas?atlas=3#structure=12890 is_a: UBERON:0002240 ! spinal cord intersection_of: UBERON:0002240 ! spinal cord intersection_of: RO:0002162 NCBITaxon:9606 ! in taxon Homo sapiens relationship: BFO:0000050 DHBA:10154 ! part of neural tube property_value: IAO:0000028 "SpC" xsd:string property_value: skos:prefLabel "spinal cord ( human dev )" xsd:string [Term] id: DHBA:13061 name: anteroventral periventricular nucleus synonym: "AVPe" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=138322603#structure=13061 xref: http://atlas.brain-map.org/atlas?atlas=138322605#structure=13061 xref: http://atlas.brain-map.org/atlas?atlas=265297126#structure=13061 xref: http://atlas.brain-map.org/atlas?atlas=3#structure=13061 is_a: UBERON:0002690 ! anteroventral periventricular nucleus intersection_of: UBERON:0002690 ! anteroventral periventricular nucleus intersection_of: RO:0002162 NCBITaxon:9606 ! in taxon Homo sapiens relationship: BFO:0000050 DHBA:10469 ! part of periventricular nucleus, preoptic portion property_value: IAO:0000028 "AVPe" xsd:string property_value: skos:prefLabel "anteroventral periventricular nucleus ( human dev )" xsd:string [Term] id: DHBA:13063 name: median preoptic nucleus synonym: "MnPO" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=138322603#structure=13063 xref: http://atlas.brain-map.org/atlas?atlas=138322605#structure=13063 xref: http://atlas.brain-map.org/atlas?atlas=265297126#structure=13063 xref: http://atlas.brain-map.org/atlas?atlas=3#structure=13063 is_a: UBERON:0002625 ! median preoptic nucleus is_a: UBERON:0006568 ! hypothalamic nucleus intersection_of: UBERON:0002625 ! median preoptic nucleus intersection_of: RO:0002162 NCBITaxon:9606 ! in taxon Homo sapiens relationship: BFO:0000050 DHBA:10468 ! part of preoptic region of HTH property_value: IAO:0000028 "MnPO" xsd:string property_value: skos:prefLabel "median preoptic nucleus ( human dev )" xsd:string [Term] id: DHBA:13338 name: median eminence synonym: "ME" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=138322603#structure=13338 xref: http://atlas.brain-map.org/atlas?atlas=138322605#structure=13338 xref: http://atlas.brain-map.org/atlas?atlas=265297126#structure=13338 xref: http://atlas.brain-map.org/atlas?atlas=3#structure=13338 is_a: UBERON:0002197 ! median eminence of neurohypophysis intersection_of: UBERON:0002197 ! median eminence of neurohypophysis intersection_of: RO:0002162 NCBITaxon:9606 ! in taxon Homo sapiens relationship: BFO:0000050 DHBA:10483 ! part of tuberal region of HTH property_value: IAO:0000028 "ME" xsd:string property_value: skos:prefLabel "median eminence ( human dev )" xsd:string [Term] id: DHBA:146034908 name: adjoining structures of forebrain ventricles synonym: "ASFV" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=138322603#structure=146034908 xref: http://atlas.brain-map.org/atlas?atlas=138322605#structure=146034908 xref: http://atlas.brain-map.org/atlas?atlas=265297126#structure=146034908 xref: http://atlas.brain-map.org/atlas?atlas=3#structure=146034908 is_a: BFO:0000004 relationship: BFO:0000050 DHBA:10609 ! part of surface structures of forebrain property_value: IAO:0000028 "ASFV" xsd:string property_value: skos:prefLabel "adjoining structures of forebrain ventricles ( human dev )" xsd:string [Term] id: DHBA:146034938 name: ventral tegmental region of midbrain synonym: "VTR" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=138322603#structure=146034938 xref: http://atlas.brain-map.org/atlas?atlas=138322605#structure=146034938 xref: http://atlas.brain-map.org/atlas?atlas=265297126#structure=146034938 xref: http://atlas.brain-map.org/atlas?atlas=3#structure=146034938 is_a: BFO:0000004 relationship: BFO:0000050 DHBA:12195 ! part of midbrain tegmentum property_value: IAO:0000028 "VTR" xsd:string property_value: skos:prefLabel "ventral tegmental region of midbrain ( human dev )" xsd:string [Term] id: DHBA:146035012 name: adjoining structures of fourth ventricle synonym: "AS4V" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=138322603#structure=146035012 xref: http://atlas.brain-map.org/atlas?atlas=138322605#structure=146035012 xref: http://atlas.brain-map.org/atlas?atlas=265297126#structure=146035012 xref: http://atlas.brain-map.org/atlas?atlas=3#structure=146035012 is_a: BFO:0000004 relationship: BFO:0000050 DHBA:12856 ! part of surface structures of pons property_value: IAO:0000028 "AS4V" xsd:string property_value: skos:prefLabel "adjoining structures of fourth ventricle ( human dev )" xsd:string [Term] id: DHBA:146035048 name: gray matter of spinal cord synonym: "SGM" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=138322603#structure=146035048 xref: http://atlas.brain-map.org/atlas?atlas=138322605#structure=146035048 xref: http://atlas.brain-map.org/atlas?atlas=265297126#structure=146035048 xref: http://atlas.brain-map.org/atlas?atlas=3#structure=146035048 is_a: UBERON:0002315 ! gray matter of spinal cord intersection_of: UBERON:0002315 ! gray matter of spinal cord intersection_of: RO:0002162 NCBITaxon:9606 ! in taxon Homo sapiens relationship: BFO:0000050 DHBA:12890 ! part of spinal cord property_value: IAO:0000028 "SGM" xsd:string property_value: skos:prefLabel "gray matter of spinal cord ( human dev )" xsd:string [Term] id: DHBA:146035088 name: white matter of spinal cord synonym: "SWM" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=138322603#structure=146035088 xref: http://atlas.brain-map.org/atlas?atlas=138322605#structure=146035088 xref: http://atlas.brain-map.org/atlas?atlas=265297126#structure=146035088 xref: http://atlas.brain-map.org/atlas?atlas=3#structure=146035088 is_a: UBERON:0002318 ! white matter of spinal cord intersection_of: UBERON:0002318 ! white matter of spinal cord intersection_of: RO:0002162 NCBITaxon:9606 ! in taxon Homo sapiens relationship: BFO:0000050 DHBA:12890 ! part of spinal cord property_value: IAO:0000028 "SWM" xsd:string property_value: skos:prefLabel "white matter of spinal cord ( human dev )" xsd:string [Term] id: DHBA:146035108 name: ventricle of spinal cord synonym: "SV" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=138322603#structure=146035108 xref: http://atlas.brain-map.org/atlas?atlas=138322605#structure=146035108 xref: http://atlas.brain-map.org/atlas?atlas=265297126#structure=146035108 xref: http://atlas.brain-map.org/atlas?atlas=3#structure=146035108 is_a: UBERON:0002291 ! central canal of spinal cord intersection_of: UBERON:0002291 ! central canal of spinal cord intersection_of: RO:0002162 NCBITaxon:9606 ! in taxon Homo sapiens relationship: BFO:0000050 DHBA:12890 ! part of spinal cord property_value: IAO:0000028 "SV" xsd:string property_value: skos:prefLabel "ventricle of spinal cord ( human dev )" xsd:string [Term] id: DHBA:146035116 name: surface structures of spinal cord synonym: "SSS" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=138322603#structure=146035116 xref: http://atlas.brain-map.org/atlas?atlas=138322605#structure=146035116 xref: http://atlas.brain-map.org/atlas?atlas=265297126#structure=146035116 xref: http://atlas.brain-map.org/atlas?atlas=3#structure=146035116 is_a: BFO:0000004 relationship: BFO:0000050 DHBA:12890 ! part of spinal cord property_value: IAO:0000028 "SSS" xsd:string property_value: skos:prefLabel "surface structures of spinal cord ( human dev )" xsd:string [Term] id: DHBA:146035120 name: roots of spinal nerves synonym: "rsn" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=138322603#structure=146035120 xref: http://atlas.brain-map.org/atlas?atlas=138322605#structure=146035120 xref: http://atlas.brain-map.org/atlas?atlas=265297126#structure=146035120 xref: http://atlas.brain-map.org/atlas?atlas=3#structure=146035120 is_a: UBERON:0009623 ! spinal nerve root is_a: UBERON:0011215 ! central nervous system cell part cluster intersection_of: UBERON:0009623 ! spinal nerve root intersection_of: RO:0002162 NCBITaxon:9606 ! in taxon Homo sapiens relationship: BFO:0000050 DHBA:146035116 ! part of surface structures of spinal cord property_value: IAO:0000028 "rsn" xsd:string property_value: skos:prefLabel "roots of spinal nerves ( human dev )" xsd:string [Term] id: DHBA:15544 name: optic nerve synonym: "on" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=138322603#structure=15544 xref: http://atlas.brain-map.org/atlas?atlas=138322605#structure=15544 xref: http://atlas.brain-map.org/atlas?atlas=265297126#structure=15544 xref: http://atlas.brain-map.org/atlas?atlas=3#structure=15544 is_a: UBERON:0000941 ! cranial nerve II intersection_of: UBERON:0000941 ! cranial nerve II intersection_of: RO:0002162 NCBITaxon:9606 ! in taxon Homo sapiens relationship: BFO:0000050 DHBA:10568 ! part of forebrain ipsilateral fiber tracts property_value: IAO:0000028 "on" xsd:string property_value: skos:prefLabel "optic nerve ( human dev )" xsd:string [Term] id: DHBA:15546 name: mammillary body synonym: "MB" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=138322603#structure=15546 xref: http://atlas.brain-map.org/atlas?atlas=138322605#structure=15546 xref: http://atlas.brain-map.org/atlas?atlas=265297126#structure=15546 xref: http://atlas.brain-map.org/atlas?atlas=3#structure=15546 is_a: UBERON:0002206 ! mammillary body intersection_of: UBERON:0002206 ! mammillary body intersection_of: RO:0002162 NCBITaxon:9606 ! in taxon Homo sapiens relationship: BFO:0000050 DHBA:10609 ! part of surface structures of forebrain property_value: IAO:0000028 "MB" xsd:string property_value: skos:prefLabel "mammillary body ( human dev )" xsd:string [Term] id: DHBA:266441551 name: anterior hypothalamic area synonym: "AnHA" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=138322603#structure=266441551 xref: http://atlas.brain-map.org/atlas?atlas=138322605#structure=266441551 xref: http://atlas.brain-map.org/atlas?atlas=265297126#structure=266441551 xref: http://atlas.brain-map.org/atlas?atlas=3#structure=266441551 is_a: UBERON:0002550 ! anterior hypothalamic region intersection_of: UBERON:0002550 ! anterior hypothalamic region intersection_of: RO:0002162 NCBITaxon:9606 ! in taxon Homo sapiens relationship: BFO:0000050 DHBA:10473 ! part of supraoptic region of HTH property_value: IAO:0000028 "AnHA" xsd:string property_value: skos:prefLabel "anterior hypothalamic area ( human dev )" xsd:string [Term] id: DHBA:266441713 name: trigeminal nuclei synonym: "5N" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=138322603#structure=266441713 xref: http://atlas.brain-map.org/atlas?atlas=138322605#structure=266441713 xref: http://atlas.brain-map.org/atlas?atlas=265297126#structure=266441713 xref: http://atlas.brain-map.org/atlas?atlas=3#structure=266441713 is_a: DHBA:10654 ! gray matter of the hindbrain is_a: UBERON:0007641 ! trigeminal nuclear complex intersection_of: UBERON:0007641 ! trigeminal nuclear complex intersection_of: RO:0002162 NCBITaxon:9606 ! in taxon Homo sapiens relationship: BFO:0000050 DHBA:12503 ! part of other nuclei in pontine tegmentum property_value: IAO:0000028 "5N" xsd:string property_value: skos:prefLabel "trigeminal nuclei ( human dev )" xsd:string [Term] id: GO:0000001 name: mitochondrion inheritance namespace: biological_process def: "The distribution of mitochondria, including the mitochondrial genome, into daughter cells after mitosis or meiosis, mediated by interactions between mitochondria and the cytoskeleton." [GOC:mcc, PMID:10873824, PMID:11389764] synonym: "mitochondrial inheritance" EXACT [] is_a: GO:0048308 ! organelle inheritance is_a: GO:0048311 ! mitochondrion distribution intersection_of: GO:0048308 ! organelle inheritance intersection_of: results_in_distribution_of GO:0005739 ! mitochondrion relationship: results_in_distribution_of GO:0005739 ! mitochondrion [Term] id: GO:0000011 name: vacuole inheritance namespace: biological_process def: "The distribution of vacuoles into daughter cells after mitosis or meiosis, mediated by interactions between vacuoles and the cytoskeleton." [GOC:mcc, PMID:10873824, PMID:14616069] is_a: GO:0007033 ! vacuole organization is_a: GO:0048308 ! organelle inheritance intersection_of: GO:0048308 ! organelle inheritance intersection_of: results_in_distribution_of GO:0005773 ! vacuole relationship: results_in_distribution_of GO:0005773 ! vacuole property_value: RO:0002161 NCBITaxon:4896 [Term] id: GO:0000018 name: regulation of DNA recombination namespace: biological_process def: "Any process that modulates the frequency, rate or extent of DNA recombination, a DNA metabolic process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents." [GOC:go_curators, ISBN:0198506732] is_a: GO:0051052 ! regulation of DNA metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0006310 ! regulates DNA recombination relationship: RO:0002211 GO:0006310 ! regulates DNA recombination [Term] id: GO:0000041 name: transition metal ion transport namespace: biological_process def: "The directed movement of transition metal ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver." [ISBN:0198506732] synonym: "transition metal transport" EXACT [] is_a: GO:0030001 ! metal ion transport intersection_of: GO:0006810 ! transport intersection_of: RO:0004009 CHEBI:33515 ! has primary input relationship: RO:0004009 CHEBI:33515 ! has primary input [Term] id: GO:0000048 name: peptidyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: peptidyl-tRNA(1) + aminoacyl-tRNA(2) = tRNA(1) + peptidylaminoacyl-tRNA(2). This reaction is catalyzed by a ribozyme." [PMID:11433365, PMID:9242921] xref: EC:2.3.2.12 xref: MetaCyc:PEPTIDYLTRANSFERASE-RXN xref: Reactome:R-HSA-156912 "Peptide transfer from P-site tRNA to the A-site tRNA" is_a: GO:0016755 ! aminoacyltransferase activity is_a: GO:0140096 ! catalytic activity, acting on a protein is_a: GO:0140101 ! catalytic activity, acting on a tRNA property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/22192" xsd:anyURI property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/25493" xsd:anyURI [Term] id: GO:0000049 name: tRNA binding namespace: molecular_function def: "Binding to a transfer RNA." [GOC:ai] synonym: "base pairing with tRNA" NARROW [] xref: Reactome:R-HSA-2408509 "Sec-tRNA(Sec) binds to EEFSEC:GTP" is_a: GO:0003723 ! RNA binding intersection_of: GO:0005488 ! binding intersection_of: RO:0004009 CHEBI:17843 ! has primary input relationship: RO:0004009 CHEBI:17843 ! has primary input [Term] id: GO:0000070 name: mitotic sister chromatid segregation namespace: biological_process def: "The cell cycle process in which replicated homologous chromosomes are organized and then physically separated and apportioned to two sets during the mitotic cell cycle. Each replicated chromosome, composed of two sister chromatids, aligns at the cell equator, paired with its homologous partner. One homolog of each morphologic type goes into each of the resulting chromosome sets." [GOC:ai, GOC:jl] subset: goslim_pombe synonym: "mitotic chromosome segregation" EXACT [] synonym: "mitotic sister-chromatid adhesion release" NARROW [] xref: Reactome:R-HSA-2500257 "Resolution of Sister Chromatid Cohesion" is_a: GO:0000819 ! sister chromatid segregation is_a: GO:1903047 ! mitotic cell cycle process intersection_of: GO:0098813 ! nuclear chromosome segregation intersection_of: BFO:0000050 GO:0140014 ! part of mitotic nuclear division relationship: BFO:0000050 GO:0140014 ! part of mitotic nuclear division [Term] id: GO:0000105 name: L-histidine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of L-histidine, 2-amino-3-(1H-imidazol-4-yl)propanoic acid." [GOC:go_curators] synonym: "histidine anabolism" EXACT [] synonym: "histidine biosynthesis" EXACT [] synonym: "histidine biosynthetic process" BROAD [] synonym: "histidine formation" EXACT [] synonym: "histidine synthesis" EXACT [] xref: MetaCyc:HISTSYN-PWY is_a: GO:0006547 ! L-histidine metabolic process is_a: GO:0009073 ! aromatic amino acid family biosynthetic process is_a: GO:0170034 ! L-amino acid biosynthetic process is_a: GO:0170038 ! proteinogenic amino acid biosynthetic process intersection_of: GO:0009058 ! biosynthetic process intersection_of: RO:0004008 CHEBI:57595 ! has primary output relationship: RO:0004008 CHEBI:57595 ! has primary output property_value: RO:0002161 NCBITaxon:7742 [Term] id: GO:0000139 name: Golgi membrane namespace: cellular_component def: "The lipid bilayer surrounding any of the compartments of the Golgi apparatus." [GOC:mah] synonym: "Golgi apparatus membrane" EXACT [] is_a: GO:0098588 ! bounding membrane of organelle intersection_of: GO:0016020 ! membrane intersection_of: RO:0002007 GO:0005794 ! bounding layer of Golgi apparatus relationship: RO:0002007 GO:0005794 ! bounding layer of Golgi apparatus [Term] id: GO:0000146 name: microfilament motor activity namespace: molecular_function def: "A motor activity that generates movement along a microfilament, driven by ATP hydrolysis." [PMID:29716949] synonym: "actin filament motor activity" EXACT [GOC:dph] synonym: "actin-activated ATPase activity" EXACT [] synonym: "actin-dependent ATPase activity" EXACT [] synonym: "actin-filament motor activity" EXACT [] synonym: "muscle motor activity" NARROW [] synonym: "myosin ATPase activity" RELATED [] xref: EC:5.6.1.8 xref: Reactome:R-HSA-2316352 "SLC2A4 (GLUT4) vesicle translocates and docks at the plasma membrane" xref: Reactome:R-HSA-432237 "Translocation of Aquaporin-2 from intracellular vesicles to the apical plasma membrane" xref: Reactome:R-HSA-9023171 "Insulin secretory granule translocates across the cortical actin network" is_a: GO:0003774 ! cytoskeletal motor activity is_a: GO:0120544 ! polypeptide conformation or assembly isomerase activity is_a: GO:0140657 ! ATP-dependent activity intersection_of: GO:0003774 ! cytoskeletal motor activity intersection_of: has_participant GO:0005884 ! actin filament relationship: has_participant GO:0005884 ! actin filament property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/20877" xsd:anyURI property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/29690" xsd:anyURI [Term] id: GO:0000166 name: nucleotide binding namespace: molecular_function def: "Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684] subset: goslim_chembl subset: goslim_metagenomics subset: goslim_pir subset: goslim_plant is_a: GO:1901265 ! nucleoside phosphate binding is_a: GO:1901363 ! heterocyclic compound binding intersection_of: GO:0005488 ! binding intersection_of: RO:0004009 CHEBI:36976 ! has primary input relationship: RO:0004009 CHEBI:36976 ! has primary input [Term] id: GO:0000226 name: microtubule cytoskeleton organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins." [GOC:mah] subset: goslim_pombe synonym: "microtubule cytoskeleton organisation" EXACT [GOC:mah] synonym: "microtubule cytoskeleton organization and biogenesis" RELATED [GOC:mah] is_a: GO:0007010 ! cytoskeleton organization is_a: GO:0007017 ! microtubule-based process intersection_of: GO:0016043 ! cellular component organization intersection_of: RO:0002592 GO:0015630 ! results in organization of microtubule cytoskeleton relationship: RO:0002592 GO:0015630 ! results in organization of microtubule cytoskeleton property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/23114" xsd:anyURI property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/23195" xsd:anyURI [Term] id: GO:0000228 name: nuclear chromosome namespace: cellular_component def: "A chromosome that encodes the nuclear genome and is found in the nucleus of a eukaryotic cell during the cell cycle phases when the nucleus is intact." [GOC:dph, GOC:mah] subset: goslim_chembl subset: goslim_generic synonym: "nuclear interphase chromosome" NARROW [] is_a: GO:0005694 ! chromosome intersection_of: GO:0005694 ! chromosome intersection_of: BFO:0000050 GO:0005634 ! part of nucleus relationship: BFO:0000050 GO:0031981 ! part of nuclear lumen [Term] id: GO:0000262 name: mitochondrial chromosome namespace: cellular_component def: "A chromosome found in the mitochondrion of a eukaryotic cell." [GOC:mah] synonym: "mitochondrial DNA" NARROW [] synonym: "mitochondrial genome" RELATED [] synonym: "mtDNA" NARROW [] xref: NIF_Subcellular:sao1186327184 is_a: GO:0005694 ! chromosome intersection_of: GO:0005694 ! chromosome intersection_of: BFO:0000050 GO:0005739 ! part of mitochondrion relationship: BFO:0000050 GO:0042645 ! part of mitochondrial nucleoid [Term] id: GO:0000266 name: mitochondrial fission namespace: biological_process def: "The division of a mitochondrion within a cell to form two or more separate mitochondrial compartments." [PMID:11038192] synonym: "mitochondrial division" EXACT [] synonym: "mitochondrial proliferation" RELATED [] is_a: GO:0007005 ! mitochondrion organization is_a: GO:0048285 ! organelle fission intersection_of: GO:0048285 ! organelle fission intersection_of: results_in_fission_of GO:0005739 ! mitochondrion relationship: results_in_fission_of GO:0005739 ! mitochondrion [Term] id: GO:0000271 name: polysaccharide biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a polysaccharide, a polymer of many (typically more than 10) monosaccharide residues linked glycosidically." [GOC:go_curators] synonym: "glycan biosynthesis" EXACT [] synonym: "glycan biosynthetic process" EXACT [] synonym: "polysaccharide anabolism" EXACT [] synonym: "polysaccharide biosynthesis" EXACT [] synonym: "polysaccharide formation" EXACT [] synonym: "polysaccharide synthesis" EXACT [] is_a: GO:0005976 ! polysaccharide metabolic process is_a: GO:0009059 ! macromolecule biosynthetic process is_a: GO:0016051 ! carbohydrate biosynthetic process intersection_of: GO:0009058 ! biosynthetic process intersection_of: RO:0004008 CHEBI:18154 ! has primary output relationship: RO:0004008 CHEBI:18154 ! has primary output [Term] id: GO:0000272 name: polysaccharide catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of a polysaccharide, a polymer of many (typically more than 10) monosaccharide residues linked glycosidically." [PMID:33139480] synonym: "multicellular organismal polysaccharide catabolic process" NARROW [] synonym: "polysaccharide breakdown" EXACT [] synonym: "polysaccharide catabolism" EXACT [] synonym: "polysaccharide degradation" EXACT [] is_a: GO:0005976 ! polysaccharide metabolic process is_a: GO:0009057 ! macromolecule catabolic process is_a: GO:0016052 ! carbohydrate catabolic process intersection_of: GO:0009056 ! catabolic process intersection_of: RO:0004009 CHEBI:18154 ! has primary input relationship: RO:0004009 CHEBI:18154 ! has primary input [Term] id: GO:0000278 name: mitotic cell cycle namespace: biological_process def: "Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent." [GOC:mah, ISBN:0815316194] comment: Note that this term should not be confused with 'GO:0140014 ; mitotic nuclear division'. 'GO:0000278 ; mitotic cell cycle represents the entire mitotic cell cycle, while 'GO:0140014 ; mitotic nuclear division' specifically represents the actual nuclear division step of the mitotic cell cycle. subset: goslim_chembl subset: goslim_drosophila subset: goslim_generic subset: goslim_yeast synonym: "mitosis" RELATED [] xref: Reactome:R-HSA-69278 "Cell Cycle, Mitotic" xref: Wikipedia:Mitosis is_a: BFO:0000003 is_a: GO:0007049 ! cell cycle intersection_of: GO:0007049 ! cell cycle intersection_of: BFO:0000051 GO:0140014 ! has part mitotic nuclear division relationship: BFO:0000051 GO:0140014 ! has part mitotic nuclear division [Term] id: GO:0000279 name: M phase namespace: biological_process def: "A cell cycle phase during which nuclear division occurs, and which is comprises the phases: prophase, metaphase, anaphase and telophase." [GOC:mtg_cell_cycle] comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). subset: gocheck_do_not_annotate synonym: "M-phase" EXACT [] xref: Wikipedia:M_phase is_a: GO:0022403 ! cell cycle phase [Term] id: GO:0000280 name: nuclear division namespace: biological_process def: "The division of a cell nucleus into two nuclei, with DNA and other nuclear contents distributed between the daughter nuclei." [GOC:mah] subset: goslim_pir synonym: "karyokinesis" RELATED [] is_a: GO:0048285 ! organelle fission intersection_of: GO:0048285 ! organelle fission intersection_of: results_in_fission_of GO:0005634 ! nucleus relationship: results_in_fission_of GO:0005634 ! nucleus [Term] id: GO:0000295 name: adenine nucleotide transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of adenine nucleotides (AMP, ADP, and ATP) from one side of a membrane to the other." [PMID:11566870] xref: Reactome:R-HSA-389652 "PMP34-mediated exchange of cytosolic ATP for peroxisomal AMP" is_a: GO:0015216 ! purine nucleotide transmembrane transporter activity intersection_of: GO:0015215 ! nucleotide transmembrane transporter activity intersection_of: RO:0004009 CHEBI:61293 ! has primary input relationship: BFO:0000050 GO:0051503 ! part of adenine nucleotide transport relationship: RO:0004009 CHEBI:61293 ! has primary input [Term] id: GO:0000302 name: response to reactive oxygen species namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a reactive oxygen species stimulus. Reactive oxygen species include singlet oxygen, superoxide, and oxygen free radicals." [GOC:krc] synonym: "response to active oxygen species" EXACT [] synonym: "response to AOS" EXACT [] synonym: "response to reactive oxidative species" EXACT [] synonym: "response to reactive oxygen intermediate" EXACT [] synonym: "response to ROI" EXACT [] synonym: "response to ROS" EXACT [] is_a: GO:0006979 ! response to oxidative stress is_a: GO:1901700 ! response to oxygen-containing compound intersection_of: GO:0050896 ! response to stimulus intersection_of: RO:0004009 CHEBI:26523 ! has primary input relationship: RO:0004009 CHEBI:26523 ! has primary input [Term] id: GO:0000303 name: response to superoxide namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a superoxide stimulus. Superoxide is the anion, oxygen-, formed by addition of one electron to dioxygen (O2) or any compound containing the superoxide anion." [GOC:krc, ISBN:0198506732] is_a: GO:0000305 ! response to oxygen radical intersection_of: GO:0050896 ! response to stimulus intersection_of: RO:0004009 CHEBI:18421 ! has primary input relationship: RO:0004009 CHEBI:18421 ! has primary input [Term] id: GO:0000305 name: response to oxygen radical namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an oxygen radical stimulus. An oxygen radical is any oxygen species that carries a free electron; examples include hydroxyl radicals and the superoxide anion." [GOC:krc, ISBN:0124325653] is_a: GO:0000302 ! response to reactive oxygen species intersection_of: GO:0050896 ! response to stimulus intersection_of: RO:0004009 CHEBI:61073 ! has primary input relationship: RO:0004009 CHEBI:61073 ! has primary input [Term] id: GO:0000313 name: organellar ribosome namespace: cellular_component def: "A ribosome contained within a subcellular membrane-bounded organelle." [GOC:mah, GOC:mcc] is_a: GO:0005840 ! ribosome intersection_of: GO:0005840 ! ribosome intersection_of: BFO:0000050 GO:0043226 ! part of organelle relationship: BFO:0000050 GO:0043226 ! part of organelle [Term] id: GO:0000323 name: lytic vacuole namespace: cellular_component def: "A vacuole that is maintained at an acidic pH and which contains degradative enzymes, including a wide variety of acid hydrolases." [GOC:krc] is_a: GO:0005773 ! vacuole [Term] id: GO:0000578 name: embryonic axis specification namespace: biological_process def: "The establishment, maintenance and elaboration of a pattern along a line or a point in an embryo." [GOC:dph, GOC:go_curators, GOC:sdb_2009, GOC:tb] synonym: "embryonic axis determination" RELATED [] is_a: GO:0009798 ! axis specification is_a: GO:0009880 ! embryonic pattern specification property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0000740 name: nuclear membrane fusion namespace: biological_process def: "The joining of 2 or more lipid bilayer membranes that surround the nucleus." [GOC:elh] is_a: GO:0071763 ! nuclear membrane organization is_a: GO:0090174 ! organelle membrane fusion intersection_of: GO:0061025 ! membrane fusion intersection_of: RO:0012008 GO:0031965 ! results in fusion of nuclear membrane relationship: RO:0012008 GO:0031965 ! results in fusion of nuclear membrane [Term] id: GO:0000741 name: karyogamy namespace: biological_process def: "The creation of a single nucleus from multiple nuclei as a result of fusing the lipid bilayers that surround each nuclei." [GOC:elh] synonym: "nuclear fusion" EXACT [] synonym: "nuclear fusion during karyogamy" EXACT [] xref: Wikipedia:Karyogamy is_a: GO:0006997 ! nucleus organization is_a: GO:0048284 ! organelle fusion intersection_of: GO:0048284 ! organelle fusion intersection_of: RO:0012008 GO:0005634 ! results in fusion of nucleus relationship: BFO:0000050 GO:0006997 ! part of nucleus organization relationship: RO:0012008 GO:0005634 ! results in fusion of nucleus [Term] id: GO:0000768 name: syncytium formation by plasma membrane fusion namespace: biological_process def: "The formation of a syncytium, a mass of cytoplasm containing several nuclei enclosed within a single plasma membrane, by the fusion of the plasma membranes of two or more individual cells." [GOC:mtg_muscle, GOC:tb] synonym: "cell fusion" BROAD [] is_a: GO:0006949 ! syncytium formation is_a: GO:0140253 ! cell-cell fusion intersection_of: GO:0006949 ! syncytium formation intersection_of: BFO:0000051 GO:0045026 ! has part plasma membrane fusion [Term] id: GO:0000785 name: chromatin namespace: cellular_component def: "The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome." [GOC:elh, PMID:20404130] comment: Chromosomes include parts that are not part of the chromatin. Examples include the kinetochore. synonym: "chromosome scaffold" RELATED [] synonym: "cytoplasmic chromatin" NARROW [] synonym: "nuclear chromatin" NARROW [] xref: NIF_Subcellular:sao1615953555 is_a: GO:0110165 ! cellular anatomical structure relationship: BFO:0000050 GO:0005694 ! part of chromosome property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/28301" xsd:anyURI property_value: skos:prefLabel "chromatin" xsd:string [Term] id: GO:0000791 name: euchromatin namespace: cellular_component def: "A dispersed and relatively uncompacted form of chromatin that is in a transcription-competent conformation." [PMID:32017156] synonym: "nuclear euchromatin" RELATED [] synonym: "transcriptionally active chromatin" EXACT [] xref: NIF_Subcellular:sao445485807 xref: Wikipedia:Euchromatin is_a: GO:0000785 ! chromatin property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/22355" xsd:anyURI [Term] id: GO:0000792 name: heterochromatin namespace: cellular_component def: "A compact and highly condensed form of chromatin that is refractory to transcription." [PMID:32017156] synonym: "nuclear heterochromatin" NARROW [] synonym: "transcriptionally inactive chromatin" EXACT [] synonym: "transcriptionally silent chromatin" EXACT [] xref: NIF_Subcellular:sao581845896 xref: Wikipedia:Heterochromatin is_a: GO:0000785 ! chromatin property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/22355" xsd:anyURI property_value: skos:prefLabel "heterochromatin" xsd:string [Term] id: GO:0000803 name: sex chromosome namespace: cellular_component def: "A chromosome involved in sex determination." [GOC:elh] is_a: GO:0005694 ! chromosome relationship: RO:0002216 GO:0007530 ! capable of part of sex determination [Term] id: GO:0000819 name: sister chromatid segregation namespace: biological_process def: "The cell cycle process in which sister chromatids are organized and then physically separated and apportioned to two or more sets." [GOC:ai, GOC:elh] is_a: GO:0051276 ! chromosome organization is_a: GO:0098813 ! nuclear chromosome segregation [Term] id: GO:0000902 name: cell morphogenesis namespace: biological_process def: "The developmental process in which the size or shape of a cell is generated and organized." [GOC:clt, GOC:dph, GOC:go_curators, GOC:tb] subset: goslim_chembl subset: goslim_drosophila subset: goslim_yeast synonym: "cellular morphogenesis" EXACT [] is_a: BFO:0000003 is_a: GO:0009653 ! anatomical structure morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 CL:0000000 ! results in morphogenesis of cell relationship: RO:0002298 CL:0000000 ! results in morphogenesis of cell [Term] id: GO:0000957 name: mitochondrial RNA catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of RNA transcribed from the mitochondrial genome and occurring in the mitochondrion." [GOC:krc, GOC:mah] xref: Reactome:R-HSA-9836573 "Mitochondrial RNA degradation" is_a: GO:0000959 ! mitochondrial RNA metabolic process is_a: GO:0006401 ! RNA catabolic process intersection_of: GO:0006401 ! RNA catabolic process intersection_of: BFO:0000066 GO:0005739 ! occurs in mitochondrion [Term] id: GO:0000959 name: mitochondrial RNA metabolic process namespace: biological_process def: "The chemical reactions and pathways involving RNA transcribed from the mitochondrial genome and occurring in the mitochondrion." [GOC:krc, GOC:mah] is_a: GO:0016070 ! RNA metabolic process intersection_of: GO:0016070 ! RNA metabolic process intersection_of: BFO:0000066 GO:0005739 ! occurs in mitochondrion relationship: BFO:0000066 GO:0005739 ! occurs in mitochondrion relationship: RO:0002162 NCBITaxon:2759 ! in taxon Eukaryota [Term] id: GO:0000960 name: regulation of mitochondrial RNA catabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving catabolism in the mitochondrion of RNA transcribed from the mitochondrial genome." [GOC:krc, GOC:mah] is_a: GO:0009894 ! regulation of catabolic process is_a: GO:0051252 ! regulation of RNA metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0000957 ! regulates mitochondrial RNA catabolic process relationship: RO:0002211 GO:0000957 ! regulates mitochondrial RNA catabolic process [Term] id: GO:0000961 name: negative regulation of mitochondrial RNA catabolic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving catabolism in the mitochondrion of RNA transcribed from the mitochondrial genome." [GOC:krc, GOC:mah] is_a: GO:0000960 ! regulation of mitochondrial RNA catabolic process is_a: GO:1902369 ! negative regulation of RNA catabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0000957 ! negatively regulates mitochondrial RNA catabolic process relationship: RO:0002212 GO:0000957 ! negatively regulates mitochondrial RNA catabolic process [Term] id: GO:0000962 name: positive regulation of mitochondrial RNA catabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving catabolism in the mitochondrion of RNA transcribed from the mitochondrial genome." [GOC:krc, GOC:mah] is_a: GO:0000960 ! regulation of mitochondrial RNA catabolic process is_a: GO:0009896 ! positive regulation of catabolic process is_a: GO:0051254 ! positive regulation of RNA metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0000957 ! positively regulates mitochondrial RNA catabolic process relationship: RO:0002213 GO:0000957 ! positively regulates mitochondrial RNA catabolic process [Term] id: GO:0001101 name: response to acid chemical namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus by the chemical structure of the anion portion of a dissociated acid (rather than the acid acting as a proton donor). The acid chemical may be in gaseous, liquid or solid form." [GOC:go_curators, GOC:rn] comment: This term should be used to describe a response to a specific acid as a chemical. E.g., if an organism were responding to glutamate, then the response would be glutamate-specific; the organism is actually responding to the chemical structure of the anion portion of the dissociated acid. Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. If annotating experiments where an acid is playing a role as a proton donor, please annotate to GO:0010447 'response to acidic pH' instead. subset: gocheck_do_not_annotate synonym: "response to acid" BROAD [] synonym: "response to acid anion" RELATED [] synonym: "response to oxoanion" RELATED [] is_a: GO:0042221 ! response to chemical [Term] id: GO:0001501 name: skeletal system development namespace: biological_process def: "The process whose specific outcome is the progression of the skeleton over time, from its formation to the mature structure. The skeleton is the bony framework of the body in vertebrates (endoskeleton) or the hard outer envelope of insects (exoskeleton or dermoskeleton)." [GOC:dph, GOC:jid, GOC:tb] synonym: "skeletal development" EXACT [] is_a: GO:0048731 ! system development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0001434 ! results in development of skeletal system relationship: RO:0002162 NCBITaxon:33213 ! in taxon Bilateria relationship: RO:0002296 UBERON:0001434 ! results in development of skeletal system [Term] id: GO:0001503 name: ossification namespace: biological_process def: "The formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance." [GOC:mtg_mpo, PMID:17572649] comment: Note that this term does not have a 'developmental process' parent because ossification isn't necessarily developmental, can also occur as part of bone remodeling. Instead use 'ossification involved in bone maturation ; GO:0043931'. synonym: "bone biosynthesis" EXACT [] synonym: "bone formation" EXACT [] synonym: "osteogenesis" EXACT [] xref: Wikipedia:Ossification is_a: BFO:0000003 is_a: GO:0032501 ! multicellular organismal process intersection_of: GO:0032501 ! multicellular organismal process intersection_of: RO:0002297 UBERON:0001474 ! results in formation of anatomical entity bone element relationship: RO:0002162 NCBITaxon:7742 ! in taxon Vertebrata relationship: RO:0002297 UBERON:0001474 ! results in formation of anatomical entity bone element [Term] id: GO:0001504 name: neurotransmitter uptake namespace: biological_process def: "The directed movement of neurotransmitters into neurons or glial cells. This process leads to inactivation and recycling of neurotransmitters." [ISBN:0123668387] subset: goslim_synapse synonym: "neurotransmitter import" EXACT [GOC:dph, GOC:tb] synonym: "neurotransmitter import into glial cell" NARROW [] synonym: "neurotransmitter import into neuron" NARROW [] synonym: "neurotransmitter recycling" BROAD [] xref: Reactome:R-HSA-112313 "Neurotransmitter uptake and metabolism In glial cells" is_a: GO:0006836 ! neurotransmitter transport is_a: GO:0098657 ! import into cell relationship: RO:0002339 GO:0005829 ! has target end location cytosol [Term] id: GO:0001507 name: acetylcholine catabolic process in synaptic cleft namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of acetylcholine that occurs in the synaptic cleft during synaptic transmission." [GOC:ai] synonym: "acetylcholine breakdown in synaptic cleft" EXACT [] synonym: "acetylcholine degradation in synaptic cleft" EXACT [] is_a: GO:0006581 ! acetylcholine catabolic process intersection_of: GO:0006581 ! acetylcholine catabolic process intersection_of: BFO:0000066 GO:0043083 ! occurs in synaptic cleft relationship: BFO:0000050 GO:0007271 ! part of synaptic transmission, cholinergic relationship: BFO:0000066 GO:0043083 ! occurs in synaptic cleft [Term] id: GO:0001508 name: action potential namespace: biological_process def: "A process in which membrane potential cycles through a depolarizing spike, triggered in response to depolarization above some threshold, followed by repolarization. This cycle is driven by the flow of ions through various voltage gated channels with different thresholds and ion specificities." [GOC:dph, GOC:go_curators, GOC:tb, ISBN:978-0-07-139011-8] comment: Action potentials typically propagate across excitable membranes. This class covers both action potentials that propagate and those that fail to do so. is_a: GO:0042391 ! regulation of membrane potential property_value: RO:0002161 NCBITaxon:4895 [Term] id: GO:0001518 name: voltage-gated sodium channel complex namespace: cellular_component def: "A sodium channel in a cell membrane whose opening is governed by the membrane potential." [ISBN:0198506732] synonym: "voltage gated sodium channel complex" EXACT [] synonym: "voltage-dependent sodium channel complex" EXACT [] synonym: "voltage-sensitive sodium channel complex" EXACT [] xref: NIF_Subcellular:sao785001660 is_a: GO:0034706 ! sodium channel complex is_a: GO:0098797 ! plasma membrane protein complex intersection_of: GO:0032991 ! protein-containing complex intersection_of: RO:0002215 GO:0005248 ! capable of voltage-gated sodium channel activity relationship: RO:0002215 GO:0005248 ! capable of voltage-gated sodium channel activity [Term] id: GO:0001525 name: angiogenesis namespace: biological_process def: "Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels." [ISBN:0878932453] synonym: "blood vessel formation from pre-existing blood vessels" EXACT systematic_synonym [] xref: Wikipedia:Angiogenesis is_a: BFO:0000003 is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0001981 ! results in formation of anatomical entity blood vessel relationship: BFO:0000050 GO:0048514 ! part of blood vessel morphogenesis relationship: RO:0002297 UBERON:0001981 ! results in formation of anatomical entity blood vessel [Term] id: GO:0001534 name: radial spoke namespace: cellular_component def: "Protein complex that links the outer microtubule doublet of a 9+2 type ciliary or flagellar axoneme with the sheath that surrounds the central pair of microtubules. Composed of a stalk that attaches to each doublet microtubule and a globular structure (spoke head) that projects toward the central pair of microtubules." [GOC:krc, ISBN:0124325653, PMID:22118931, PMID:25694453, PMID:34871179, PMID:9450971] comment: Radial spokes are involved in some types of beating motions of the cilium. The radial spoke is usually a T-shaped structure comprised of a short base that attaches to the A-microtubule of an axonemal outer microtubule doublet (MTD) of a cilium, an elongated stalk, a neck complex, and an orthogonal head structure that extends perpendicularly towards the inner sheath and the central pair (CP) microtubules. Groups of radial spokes (RSs) repeat along the MTD with regular spacing. In most organisms, each group of radial spokes is comprised of a triplet of spokes: RS1, RS2, and RS3. In some organisms (e.g. Chlamydomonas and Sarcophaga bullata), each group contains a doublet of radial spokes: RS1 and RS2, while RS3 is represented only as a stump (referred to as RS3S) attached to the A-microtubule but lacking the rest of the stalk structure and entirely lacking the head structure. {xref="PMID:9450971", xref="GOC:krc", xref="PMID:34871179", xref="PMID:25694453"} subset: goslim_pir xref: Wikipedia:Radial_spoke is_a: BFO:0000004 is_a: GO:0032991 ! protein-containing complex relationship: BFO:0000050 GO:0005930 ! part of axoneme property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/25321" xsd:anyURI property_value: RO:0002161 NCBITaxon:3176 property_value: RO:0002161 NCBITaxon:3378 property_value: RO:0002161 NCBITaxon:3398 property_value: RO:0002161 NCBITaxon:4890 property_value: RO:0002161 NCBITaxon:5782 [Term] id: GO:0001539 name: cilium or flagellum-dependent cell motility namespace: biological_process def: "Cell motility due to movement of eukaryotic cilia or bacterial-type flagella or archaeal-type flagella." [GOC:cilia, GOC:hjd, GOC:krc] comment: Note that we deem eukaryotic cilia and microtubule-based flagella to be equivalent, while the bacterial- and archaeal-type flagella have a different structure. The former are microtubule-based structures that lash back and forth and are present only in eukaryotes, while the latter achieve motility by rotation. Bacterial- and archaeal-type flagella are superficially similar but have a different molecular composition and fine structure. These three structures never co-exist in the same organism. Therefore, GO:0001539 'cilium or flagellum-dependent cell motility' is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term. Direct annotations to GO:0001539 'cilium or flagellum-dependent cell motility' may be amended during annotation QC. subset: gocheck_do_not_annotate synonym: "ciliary or bacterial-type flagellar motility" RELATED [] synonym: "ciliary/flagellar motility" EXACT [] is_a: GO:0048870 ! cell motility property_value: RO:0002161 NCBITaxon:4890 [Term] id: GO:0001541 name: ovarian follicle development namespace: biological_process def: "The process whose specific outcome is the progression of the ovarian follicle over time, from its formation to the mature structure." [https://www.ncbi.nlm.nih.gov/books/NBK279054/] synonym: "follicular phase" RELATED [] is_a: GO:0048856 ! anatomical structure development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0001305 ! results in development of ovarian follicle relationship: BFO:0000050 GO:0008585 ! part of female gonad development relationship: RO:0002296 UBERON:0001305 ! results in development of ovarian follicle [Term] id: GO:0001545 name: primary ovarian follicle growth namespace: biological_process def: "Increase in size of primary follicles including oocyte growth and granulosa and/or theca cell proliferation until more than one layer of granulosa cells is present (preantral follicle)." [GOC:mtg_mpo, https://www.ncbi.nlm.nih.gov/books/NBK279054/] is_a: BFO:0000003 is_a: GO:0022602 ! ovulation cycle process is_a: GO:0048589 ! developmental growth intersection_of: GO:0040007 ! growth intersection_of: RO:0002343 UBERON:0000035 ! results in growth of primary ovarian follicle relationship: BFO:0000050 GO:0001541 ! part of ovarian follicle development relationship: RO:0002343 UBERON:0000035 ! results in growth of primary ovarian follicle [Term] id: GO:0001546 name: preantral ovarian follicle growth namespace: biological_process def: "Increase in size of follicles surrounded by two or more layers of granulosa cells up to the onset of antrum formation." [https://www.ncbi.nlm.nih.gov/books/NBK279054/] is_a: BFO:0000003 is_a: GO:0022602 ! ovulation cycle process is_a: GO:0048589 ! developmental growth intersection_of: GO:0040007 ! growth intersection_of: RO:0002343 UBERON:0000036 ! results in growth of secondary ovarian follicle relationship: BFO:0000050 GO:0001541 ! part of ovarian follicle development relationship: BFO:0000050 GO:0048162 ! part of multi-layer follicle stage relationship: RO:0002343 UBERON:0000036 ! results in growth of secondary ovarian follicle [Term] id: GO:0001547 name: antral ovarian follicle growth namespace: biological_process def: "Increase in size of antral follicles due to cell proliferation and/or growth of the antral cavity." [https://www.ncbi.nlm.nih.gov/books/NBK279054/] is_a: BFO:0000003 is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0022602 ! ovulation cycle process is_a: GO:0048589 ! developmental growth intersection_of: GO:0040007 ! growth intersection_of: RO:0002343 UBERON:0000037 ! results in growth of tertiary ovarian follicle relationship: BFO:0000050 GO:0001541 ! part of ovarian follicle development relationship: RO:0002343 UBERON:0000037 ! results in growth of tertiary ovarian follicle [Term] id: GO:0001549 name: cumulus cell differentiation namespace: biological_process def: "The process in which a subpopulation of granulosa cells surrounding the oocyte acquires the specialized features of an ovarian cumulus cell." [PMID:30010832] synonym: "ovarian cumulus cell differentiation" EXACT [] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0060014 ! granulosa cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000711 ! results in acquisition of features of cumulus granulosa cell relationship: BFO:0000050 GO:0001547 ! part of antral ovarian follicle growth relationship: BFO:0000050 GO:0048165 ! part of fused antrum stage relationship: RO:0002315 CL:0000711 ! results in acquisition of features of cumulus granulosa cell [Term] id: GO:0001552 name: ovarian follicle atresia namespace: biological_process def: "A periodic process in which immature ovarian follicles degenerate and are subsequently re-absorbed." [GOC:mtg_apoptosis, PMID:18638134] is_a: BFO:0000003 is_a: GO:0003006 ! developmental process involved in reproduction relationship: BFO:0000050 GO:0008585 ! part of female gonad development relationship: BFO:0000051 GO:0097191 ! has part extrinsic apoptotic signaling pathway relationship: has_participant UBERON:0001305 ! ovarian follicle [Term] id: GO:0001553 name: luteinization namespace: biological_process def: "The set of processes resulting in differentiation of theca and granulosa cells into luteal cells and in the formation of a corpus luteum after ovulation." [https://www.ncbi.nlm.nih.gov/books/NBK279054/] synonym: "luteal phase" RELATED [] xref: Wikipedia:Luteal_phase xref: Wikipedia:Luteinization is_a: GO:0022602 ! ovulation cycle process relationship: BFO:0000050 GO:0008585 ! part of female gonad development [Term] id: GO:0001555 name: oocyte growth namespace: biological_process def: "The developmental growth process in which an oocyte irreversibly increases in size over time by accretion and biosynthetic production of matter similar to that already present." [https://www.ncbi.nlm.nih.gov/books/NBK279054/] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0048588 ! developmental cell growth intersection_of: GO:0040007 ! growth intersection_of: RO:0002343 CL:0000023 ! results in growth of oocyte relationship: BFO:0000050 GO:0048599 ! part of oocyte development relationship: RO:0002343 CL:0000023 ! results in growth of oocyte [Term] id: GO:0001556 name: oocyte maturation namespace: biological_process def: "A developmental process, independent of morphogenetic (shape) change, that is required for an oocyte to attain its fully functional state. Oocyte maturation commences after reinitiation of meiosis commonly starting with germinal vesicle breakdown, and continues up to the second meiotic arrest prior to fertilization." [GOC:devbiol, https://www.ncbi.nlm.nih.gov/books/NBK279054/] xref: Wikipedia:Oocyte_maturation is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0048469 ! cell maturation intersection_of: GO:0021700 ! developmental maturation intersection_of: RO:0002299 CL:0000023 ! results in maturation of oocyte relationship: BFO:0000050 GO:0048599 ! part of oocyte development relationship: RO:0002299 CL:0000023 ! results in maturation of oocyte [Term] id: GO:0001558 name: regulation of cell growth namespace: biological_process def: "Any process that modulates the frequency, rate, extent or direction of cell growth." [GOC:go_curators] is_a: GO:0040008 ! regulation of growth is_a: GO:0051128 ! regulation of cellular component organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0016049 ! regulates cell growth relationship: RO:0002211 GO:0016049 ! regulates cell growth [Term] id: GO:0001560 name: regulation of cell growth by extracellular stimulus namespace: biological_process def: "Any process in which external signals modulate the frequency, rate or extent of cell growth, the irreversible increase in size of a cell over time." [GOC:dph] synonym: "interpretation of external signals that regulate cell growth" EXACT [] synonym: "regulation of cell growth by detection of exogenous stimulus" EXACT [] synonym: "regulation of cell growth by sensing of exogenous stimulus" EXACT [] synonym: "regulation of growth by exogenous signal" EXACT [] synonym: "regulation of growth by exogenous stimuli" EXACT [] synonym: "regulation of growth by exogenous stimulus" EXACT [] synonym: "regulation of growth by external signal" EXACT [] synonym: "regulation of growth by external stimuli" EXACT [] synonym: "regulation of growth by external stimulus" EXACT [] is_a: GO:0001558 ! regulation of cell growth intersection_of: GO:0001558 ! regulation of cell growth intersection_of: BFO:0000050 GO:0051716 ! part of cellular response to stimulus relationship: BFO:0000050 GO:0051716 ! part of cellular response to stimulus [Term] id: GO:0001568 name: blood vessel development namespace: biological_process def: "The process whose specific outcome is the progression of a blood vessel over time, from its formation to the mature structure. The blood vessel is the vasculature carrying blood." [GOC:hjd, UBERON:0001981] is_a: GO:0048856 ! anatomical structure development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0001981 ! results in development of blood vessel relationship: BFO:0000050 GO:0001944 ! part of vasculature development relationship: RO:0002296 UBERON:0001981 ! results in development of blood vessel [Term] id: GO:0001569 name: branching involved in blood vessel morphogenesis namespace: biological_process def: "The process of coordinated growth and sprouting of blood vessels giving rise to the organized vascular system." [GOC:dph] synonym: "patterning of blood vessels" BROAD [GOC:dph] is_a: GO:0048754 ! branching morphogenesis of an epithelial tube intersection_of: GO:0048754 ! branching morphogenesis of an epithelial tube intersection_of: BFO:0000050 GO:0048514 ! part of blood vessel morphogenesis relationship: BFO:0000050 GO:0001525 ! part of angiogenesis [Term] id: GO:0001570 name: vasculogenesis namespace: biological_process def: "The differentiation of endothelial cells from progenitor cells during blood vessel development, and the de novo formation of blood vessels and tubes." [PMID:8999798] synonym: "vascular morphogenesis" EXACT [] xref: Wikipedia:Vasculogenesis is_a: GO:0030154 ! cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002297 UBERON:0001981 ! results in formation of anatomical entity blood vessel relationship: BFO:0000050 GO:0048514 ! part of blood vessel morphogenesis relationship: RO:0002297 UBERON:0001981 ! results in formation of anatomical entity blood vessel [Term] id: GO:0001578 name: microtubule bundle formation namespace: biological_process def: "A process that results in a parallel arrangement of microtubules." [GOC:dph] synonym: "microtubule bundling" EXACT [] is_a: GO:0000226 ! microtubule cytoskeleton organization relationship: has_participant GO:0005874 ! microtubule relationship: RO:0002297 GO:0097427 ! results in formation of anatomical entity microtubule bundle [Term] id: GO:0001614 name: purinergic nucleotide receptor activity namespace: molecular_function def: "Combining with a purine nucleotide and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:mah, GOC:signaling] synonym: "P2 receptor" RELATED [PMID:9755289] synonym: "purinergic receptor activity" RELATED [] synonym: "purinoceptor" EXACT [PMID:9755289] synonym: "purinoreceptor" EXACT [PMID:9755289] is_a: GO:0016502 ! nucleotide receptor activity intersection_of: GO:0038023 ! signaling receptor activity intersection_of: RO:0004009 CHEBI:26395 ! has primary input relationship: BFO:0000050 GO:0035590 ! part of purinergic nucleotide receptor signaling pathway relationship: BFO:0000051 GO:0017076 ! has part purine nucleotide binding relationship: RO:0004009 CHEBI:26395 ! has primary input creation_date: 2010-10-22T10:57:12Z [Term] id: GO:0001621 name: G protein-coupled ADP receptor activity namespace: molecular_function def: "Combining with ADP and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:mah, GOC:signaling, PMID:11196645] synonym: "ADP receptor activity" BROAD [] synonym: "ADP-activated adenosine receptor activity" RELATED [] synonym: "ADP-activated nucleotide receptor activity" BROAD [] synonym: "K101 receptor" NARROW [] synonym: "platelet ADP receptor activity" NARROW [GOC:mah] is_a: GO:0045028 ! G protein-coupled purinergic nucleotide receptor activity intersection_of: GO:0004930 ! G protein-coupled receptor activity intersection_of: RO:0004009 CHEBI:456216 ! has primary input relationship: BFO:0000051 GO:0043531 ! has part ADP binding relationship: RO:0004009 CHEBI:456216 ! has primary input [Term] id: GO:0001649 name: osteoblast differentiation namespace: biological_process def: "The process whereby a relatively unspecialized cell acquires the specialized features of an osteoblast, a mesodermal or neural crest cell that gives rise to bone." [CL:0000062, GO_REF:0000034, GOC:jid] synonym: "osteoblast cell differentiation" EXACT [] is_a: GO:0030154 ! cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000062 ! results in acquisition of features of osteoblast relationship: BFO:0000050 GO:0001503 ! part of ossification relationship: RO:0002315 CL:0000062 ! results in acquisition of features of osteoblast [Term] id: GO:0001653 name: peptide receptor activity namespace: molecular_function def: "Combining with an extracellular or intracellular peptide to initiate a change in cell activity." [GOC:jl] synonym: "endogenous peptide receptor activity" NARROW [] synonym: "exogenous peptide receptor activity" NARROW [] is_a: BFO:0000003 is_a: GO:0038023 ! signaling receptor activity intersection_of: GO:0038023 ! signaling receptor activity intersection_of: RO:0004009 CHEBI:60466 ! has primary input relationship: BFO:0000051 GO:0042277 ! has part peptide binding relationship: RO:0004009 CHEBI:60466 ! has primary input [Term] id: GO:0001654 name: eye development namespace: biological_process def: "The process whose specific outcome is the progression of the eye over time, from its formation to the mature structure. The eye is the organ of sight." [GOC:jid, GOC:jl] xref: Wikipedia:Eye_development is_a: GO:0007423 ! sensory organ development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0000970 ! results in development of eye relationship: BFO:0000050 GO:0150063 ! part of visual system development relationship: RO:0002296 UBERON:0000970 ! results in development of eye [Term] id: GO:0001655 name: urogenital system development namespace: biological_process def: "The process whose specific outcome is the progression of the urogenital system over time, from its formation to the mature structure." [GOC:go_curators] is_a: GO:0048731 ! system development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0004122 ! results in development of genitourinary system relationship: BFO:0000051 GO:0072001 ! has part renal system development relationship: RO:0002296 UBERON:0004122 ! results in development of genitourinary system property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/22178" xsd:anyURI [Term] id: GO:0001656 name: metanephros development namespace: biological_process def: "The process whose specific outcome is the progression of the metanephros over time, from its formation to the mature structure. In mammals, the metanephros is the excretory organ of the fetus, which develops into the mature kidney and is formed from the rear portion of the nephrogenic cord. The metanephros is an endocrine and metabolic organ that filters the blood and excretes the end products of body metabolism in the form of urine." [GOC:bf, ISBN:0192800752] is_a: GO:0001822 ! kidney development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0000081 ! results in development of metanephros relationship: RO:0002296 UBERON:0000081 ! results in development of metanephros [Term] id: GO:0001657 name: ureteric bud development namespace: biological_process def: "The process whose specific outcome is the progression of the ureteric bud over time, from its formation to the mature structure." [GOC:go_curators] is_a: GO:0072164 ! mesonephric tubule development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0000084 ! results in development of ureteric bud relationship: RO:0002296 UBERON:0000084 ! results in development of ureteric bud [Term] id: GO:0001658 name: branching involved in ureteric bud morphogenesis namespace: biological_process def: "The process in which the branching structure of the ureteric bud is generated and organized. The ureteric bud is an epithelial tube that grows out from the metanephric duct. The bud elongates and branches to give rise to the ureter and kidney collecting tubules." [GOC:dph, PMID:16916378] synonym: "ureteric bud branching" EXACT [GOC:dph] is_a: GO:0048754 ! branching morphogenesis of an epithelial tube intersection_of: GO:0001763 ! morphogenesis of a branching structure intersection_of: BFO:0000050 GO:0060675 ! part of ureteric bud morphogenesis relationship: BFO:0000050 GO:0060675 ! part of ureteric bud morphogenesis [Term] id: GO:0001659 name: temperature homeostasis namespace: biological_process def: "A homeostatic process in which an organism modulates its internal body temperature." [GOC:jl] synonym: "thermoregulation" EXACT [GOC:dph, GOC:tb] xref: Wikipedia:Thermoregulation is_a: GO:0048871 ! multicellular organismal-level homeostasis property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0001664 name: G protein-coupled receptor binding namespace: molecular_function def: "Binding to a G protein-coupled receptor." [GOC:ceb, GOC:dph] synonym: "G protein coupled receptor binding" EXACT [] synonym: "G protein coupled receptor ligand" NARROW [] synonym: "G-protein coupled receptor binding" EXACT [GOC:bf] synonym: "G-protein-coupled receptor ligand" NARROW [] xref: Reactome:R-HSA-500717 "Activation of GRIK3 homomer" is_a: GO:0005102 ! signaling receptor binding [Term] id: GO:0001666 name: response to hypoxia namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level." [GOC:hjd] comment: Note that this term should not be confused with 'response to anoxia ; GO:0034059'. Note that in laboratory studies, hypoxia is typically studied at O2 concentrations ranging from 0.1 - 5%. synonym: "response to hypoxic stress" EXACT [] synonym: "response to intermittent hypoxia" NARROW [] synonym: "response to lowered oxygen tension" EXACT [] synonym: "response to sustained hypoxia" NARROW [] is_a: GO:0006950 ! response to stress is_a: GO:0036293 ! response to decreased oxygen levels [Term] id: GO:0001667 name: ameboidal-type cell migration namespace: biological_process def: "Cell migration that is accomplished by extension and retraction of a pseudopodium." [GOC:dph] comment: Note that this term refers to a mode of migration rather than to any particular cell type. synonym: "ameboid cell migration" EXACT [] synonym: "amoeboid cell migration" EXACT [] synonym: "amoeboidal cell migration" EXACT [] is_a: GO:0016477 ! cell migration property_value: RO:0002161 NCBITaxon:4890 [Term] id: GO:0001669 name: acrosomal vesicle namespace: cellular_component def: "A structure in the head of a spermatozoon that contains acid hydrolases, and is concerned with the breakdown of the outer membrane of the ovum during fertilization. It lies just beneath the plasma membrane and is derived from the lysosome." [ISBN:0124325653, ISBN:0198506732] synonym: "acrosomal granule" EXACT [GOC:sart] synonym: "acrosome" EXACT [GOC:dph] xref: Wikipedia:Acrosome is_a: GO:0030141 ! secretory granule relationship: BFO:0000050 CL:0000019 ! part of sperm property_value: RO:0002161 NCBITaxon:3176 property_value: RO:0002161 NCBITaxon:3378 property_value: RO:0002161 NCBITaxon:3398 property_value: RO:0002161 NCBITaxon:4751 property_value: RO:0002161 NCBITaxon:5782 [Term] id: GO:0001673 name: male germ cell nucleus namespace: cellular_component def: "The nucleus of a male germ cell, a reproductive cell in males." [CL:0000015, GOC:hjd, GOC:mtg_sensu] synonym: "male germ-cell nucleus" EXACT [] is_a: GO:0043073 ! germ cell nucleus intersection_of: GO:0005634 ! nucleus intersection_of: BFO:0000050 CL:0000015 ! part of male germ cell relationship: BFO:0000050 CL:0000015 ! part of male germ cell [Term] id: GO:0001674 name: female germ cell nucleus namespace: cellular_component def: "The nucleus of the female germ cell, a reproductive cell in females." [CL:0000021, GOC:hjd] synonym: "female germ-cell nucleus" EXACT [] is_a: GO:0043073 ! germ cell nucleus intersection_of: GO:0005634 ! nucleus intersection_of: BFO:0000050 CL:0000021 ! part of female germ cell relationship: BFO:0000050 CL:0000021 ! part of female germ cell [Term] id: GO:0001675 name: acrosome assembly namespace: biological_process def: "The formation of the acrosome from the spermatid Golgi." [GOC:dph, GOC:hjd, GOC:tb] synonym: "acrosome formation" EXACT [GOC:dph, GOC:tb] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0010927 ! cellular component assembly involved in morphogenesis is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism is_a: GO:0033363 ! secretory granule organization is_a: GO:0070925 ! organelle assembly intersection_of: GO:0022607 ! cellular component assembly intersection_of: RO:0002588 GO:0001669 ! results in assembly of acrosomal vesicle relationship: BFO:0000050 GO:0007286 ! part of spermatid development relationship: RO:0002588 GO:0001669 ! results in assembly of acrosomal vesicle property_value: RO:0002161 NCBITaxon:3176 property_value: RO:0002161 NCBITaxon:3378 property_value: RO:0002161 NCBITaxon:3398 property_value: RO:0002161 NCBITaxon:4751 property_value: RO:0002161 NCBITaxon:5782 [Term] id: GO:0001677 name: formation of translation initiation ternary complex namespace: biological_process def: "Formation of a complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2 (either eIF2 in eukaryotes, or IF2 in prokaryotes). In prokaryotes, fMet-tRNA (initiator) is used rather than Met-tRNA (initiator)." [GOC:hjd] synonym: "translation initiation ternary complex assembly" EXACT [] is_a: GO:0022618 ! protein-RNA complex assembly intersection_of: GO:0022607 ! cellular component assembly intersection_of: RO:0002588 GO:0044207 ! results in assembly of translation initiation ternary complex relationship: BFO:0000050 GO:0006413 ! part of translational initiation relationship: RO:0002588 GO:0044207 ! results in assembly of translation initiation ternary complex [Term] id: GO:0001678 name: intracellular glucose homeostasis namespace: biological_process def: "A homeostatic process involved in the maintenance of a steady state level of glucose within a cell." [GOC:dph, GOC:go_curators, GOC:tb] synonym: "cell glucose homeostasis" EXACT [GOC:dph, GOC:tb] synonym: "cellular glucose homeostasis" EXACT [] is_a: GO:0042593 ! glucose homeostasis is_a: GO:0055082 ! intracellular chemical homeostasis intersection_of: GO:0019725 ! cellular homeostasis intersection_of: RO:0002332 CHEBI:4167 ! regulates levels of [Term] id: GO:0001692 name: histamine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving histamine, a physiologically active amine, found in plant and animal tissue and released from mast cells as part of an allergic reaction in humans." [GOC:jl, ISBN:0395825172] synonym: "histamine metabolism" EXACT [] is_a: GO:0006576 ! biogenic amine metabolic process is_a: GO:0052803 ! imidazole-containing compound metabolic process intersection_of: GO:0008152 ! metabolic process intersection_of: RO:0004007 CHEBI:58432 ! has primary input or output relationship: RO:0004007 CHEBI:58432 ! has primary input or output [Term] id: GO:0001694 name: histamine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of histamine, a physiologically active amine, found in plant and animal tissue and released from mast cells as part of an allergic reaction in humans." [GOC:jl, ISBN:0395825172] synonym: "histamine anabolism" EXACT [] synonym: "histamine biosynthesis" EXACT [] synonym: "histamine formation" EXACT [] synonym: "histamine synthesis" EXACT [] is_a: GO:0001692 ! histamine metabolic process is_a: GO:0042401 ! biogenic amine biosynthetic process intersection_of: GO:0009058 ! biosynthetic process intersection_of: RO:0004008 CHEBI:58432 ! has primary output relationship: RO:0004008 CHEBI:58432 ! has primary output [Term] id: GO:0001695 name: histamine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of histamine, a physiologically active amine, found in plant and animal tissue and released from mast cells as part of an allergic reaction in humans." [GOC:jl, ISBN:0395825172] synonym: "histamine breakdown" EXACT [] synonym: "histamine catabolism" EXACT [] synonym: "histamine degradation" EXACT [] is_a: GO:0001692 ! histamine metabolic process is_a: GO:0042402 ! biogenic amine catabolic process is_a: GO:0052805 ! imidazole-containing compound catabolic process intersection_of: GO:0009056 ! catabolic process intersection_of: RO:0004009 CHEBI:58432 ! has primary input relationship: RO:0004009 CHEBI:58432 ! has primary input [Term] id: GO:0001696 name: gastric acid secretion namespace: biological_process def: "The regulated release of gastric acid (hydrochloric acid) by parietal or oxyntic cells during digestion." [GOC:hjd] synonym: "hydrochloric acid secretion" NARROW [] is_a: GO:0022600 ! digestive system process is_a: GO:0046717 ! acid secretion property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0001700 name: embryonic development via the syncytial blastoderm namespace: biological_process def: "The process whose specific outcome is the progression of the embryo over time, from zygote formation through syncytial blastoderm to the hatching of the first instar larva. An example of this process is found in Drosophila melanogaster." [GOC:go_curators, GOC:mtg_sensu] is_a: GO:0009792 ! embryo development ending in birth or egg hatching relationship: RO:0002162 NCBITaxon:50557 ! in taxon Insecta [Term] id: GO:0001701 name: in utero embryonic development namespace: biological_process def: "The process whose specific outcome is the progression of the embryo in the uterus over time, from formation of the zygote in the oviduct, to birth. An example of this process is found in Mus musculus." [GOC:go_curators, GOC:mtg_sensu] is_a: GO:0043009 ! chordate embryonic development relationship: RO:0002162 NCBITaxon:32525 ! in taxon Theria [Term] id: GO:0001702 name: gastrulation with mouth forming second namespace: biological_process def: "A gastrulation process in which the initial invagination becomes the anus and the mouth forms second." [GOC:go_curators, GOC:mtg_sensu] synonym: "deuterostomic gastrulation" EXACT [GOC:dph] is_a: GO:0007369 ! gastrulation relationship: RO:0002162 NCBITaxon:33511 ! in taxon Deuterostomia [Term] id: GO:0001703 name: gastrulation with mouth forming first namespace: biological_process def: "A gastrulation process in which the initial invagination becomes the mouth and the anus forms second." [GOC:go_curators, GOC:mtg_sensu] synonym: "protostomic gastrulation" NARROW [GOC:dph] is_a: GO:0007369 ! gastrulation relationship: RO:0002162 NCBITaxon:33317 ! in taxon Protostomia [Term] id: GO:0001704 name: formation of primary germ layer namespace: biological_process def: "The formation of the ectoderm, mesoderm and endoderm during gastrulation." [GOC:go_curators] is_a: BFO:0000003 is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0000923 ! results in formation of anatomical entity germ layer relationship: BFO:0000050 GO:0007369 ! part of gastrulation relationship: RO:0002297 UBERON:0000923 ! results in formation of anatomical entity germ layer [Term] id: GO:0001705 name: ectoderm formation namespace: biological_process def: "The formation of ectoderm during gastrulation." [GOC:go_curators] is_a: GO:0001704 ! formation of primary germ layer intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0000924 ! results in formation of anatomical entity ectoderm relationship: BFO:0000050 GO:0007398 ! part of ectoderm development relationship: RO:0002297 UBERON:0000924 ! results in formation of anatomical entity ectoderm [Term] id: GO:0001706 name: endoderm formation namespace: biological_process def: "The formation of the endoderm during gastrulation." [GOC:go_curators] synonym: "endoblast formation" NARROW [GOC:dph, GOC:sdb_2009, GOC:tb] xref: Reactome:R-HSA-9823730 "Formation of definitive endoderm" is_a: GO:0001704 ! formation of primary germ layer intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0000925 ! results in formation of anatomical entity endoderm relationship: BFO:0000050 GO:0007492 ! part of endoderm development relationship: RO:0002297 UBERON:0000925 ! results in formation of anatomical entity endoderm [Term] id: GO:0001707 name: mesoderm formation namespace: biological_process def: "The process that gives rise to the mesoderm. This process pertains to the initial formation of the structure from unspecified parts." [GOC:go_curators] is_a: GO:0001704 ! formation of primary germ layer intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0000926 ! results in formation of anatomical entity mesoderm relationship: BFO:0000050 GO:0048332 ! part of mesoderm morphogenesis relationship: RO:0002297 UBERON:0000926 ! results in formation of anatomical entity mesoderm [Term] id: GO:0001739 name: sex chromatin namespace: cellular_component def: "Chromatin that is part of a sex chromosome." [GOC:dos, ISBN:0198506732] is_a: GO:0000792 ! heterochromatin intersection_of: GO:0000792 ! heterochromatin intersection_of: BFO:0000050 GO:0000803 ! part of sex chromosome relationship: BFO:0000050 GO:0000803 ! part of sex chromosome [Term] id: GO:0001742 name: oenocyte differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires the specialized features of an oenocyte. Oenocytes are large secretory cells found in clusters underlying the epidermis of larval abdominal segments." [GOC:go_curators] synonym: "oenocyte cell differentiation" EXACT [] is_a: GO:0030154 ! cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000487 ! results in acquisition of features of oenocyte relationship: RO:0002315 CL:0000487 ! results in acquisition of features of oenocyte [Term] id: GO:0001743 name: lens placode formation namespace: biological_process def: "The initial developmental process that will lead to the formation of an eye." [GOC:dph] synonym: "optic placode formation" RELATED [] is_a: GO:0060788 ! ectodermal placode formation intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0003073 ! results in formation of anatomical entity lens placode relationship: BFO:0000050 GO:0048598 ! part of embryonic morphogenesis relationship: RO:0002297 UBERON:0003073 ! results in formation of anatomical entity lens placode [Term] id: GO:0001745 name: compound eye morphogenesis namespace: biological_process def: "The morphogenetic process in which the anatomical structures of the compound eye are generated and organized. The adult compound eye is a precise assembly of 700-800 ommatidia. Each ommatidium is composed of 20 cells, identified by cell type and position. An example of compound eye morphogenesis is found in Drosophila melanogaster." [GOC:dph, GOC:mtg_sensu] synonym: "insect-type retina morphogenesis" EXACT [PMID:11735386] is_a: GO:0048592 ! eye morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0000018 ! results in morphogenesis of compound eye relationship: BFO:0000050 GO:0048749 ! part of compound eye development relationship: RO:0002298 UBERON:0000018 ! results in morphogenesis of compound eye [Term] id: GO:0001751 name: compound eye photoreceptor cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires the specialized features of an eye photoreceptor cell." [GOC:go_curators] is_a: GO:0001754 ! eye photoreceptor cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:2000019 ! results in acquisition of features of compound eye photoreceptor cell relationship: BFO:0000050 GO:0001745 ! part of compound eye morphogenesis relationship: RO:0002315 CL:2000019 ! results in acquisition of features of compound eye photoreceptor cell [Term] id: GO:0001754 name: eye photoreceptor cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires the specialized features of a photoreceptor cell, as found in the eye, the primary visual organ of most organisms." [GOC:go_curators] is_a: GO:0046530 ! photoreceptor cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000287 ! results in acquisition of features of eye photoreceptor cell relationship: BFO:0000050 GO:0048592 ! part of eye morphogenesis relationship: RO:0002315 CL:0000287 ! results in acquisition of features of eye photoreceptor cell [Term] id: GO:0001755 name: neural crest cell migration namespace: biological_process def: "The characteristic movement of cells from the dorsal ridge of the neural tube to a variety of locations in a vertebrate embryo." [GOC:ascb_2009, GOC:dph, GOC:tb, ISBN:0878932437] is_a: GO:0090497 ! mesenchymal cell migration intersection_of: GO:0016477 ! cell migration intersection_of: RO:0002565 CL:0000333 ! results in movement of migratory neural crest cell relationship: BFO:0000050 GO:0014032 ! part of neural crest cell development relationship: RO:0002565 CL:0000333 ! results in movement of migratory neural crest cell [Term] id: GO:0001756 name: somitogenesis namespace: biological_process def: "The formation of mesodermal clusters that are arranged segmentally along the anterior posterior axis of an embryo." [ISBN:0721662544] synonym: "formation of mesodermal clusters" EXACT systematic_synonym [] xref: Reactome:R-HSA-9824272 "Somitogenesis" xref: Wikipedia:Somitogenesis is_a: BFO:0000003 is_a: GO:0009952 ! anterior/posterior pattern specification is_a: GO:0035282 ! segmentation is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0002329 ! results in formation of anatomical entity somite relationship: BFO:0000050 GO:0043009 ! part of chordate embryonic development relationship: BFO:0000050 GO:0061053 ! part of somite development relationship: RO:0002297 UBERON:0002329 ! results in formation of anatomical entity somite [Term] id: GO:0001763 name: morphogenesis of a branching structure namespace: biological_process def: "The process in which the anatomical structures of branches are generated and organized. A branch is a division or offshoot from a main stem. Examples in animals would include blood vessels, nerves, lymphatics and other endothelial or epithelial tubes." [ISBN:0721662544] synonym: "branching morphogenesis" EXACT [GOC:dph] is_a: GO:0009653 ! anatomical structure morphogenesis is_a: GO:0032501 ! multicellular organismal process property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0001764 name: neuron migration namespace: biological_process def: "The characteristic movement of an immature neuron from germinal zones to specific positions where they will reside as they mature." [CL:0000540, GOC:go_curators] synonym: "neuron chemotaxis" EXACT [] synonym: "neuron guidance" RELATED [] synonym: "neuronal migration" EXACT [] xref: Wikipedia:Neural_development#Neuron_migration xref: Wikipedia:Neuron_migration is_a: BFO:0000003 is_a: GO:0016477 ! cell migration intersection_of: GO:0016477 ! cell migration intersection_of: RO:0002565 CL:0000540 ! results in movement of neuron relationship: BFO:0000050 GO:0048699 ! part of generation of neurons relationship: RO:0002565 CL:0000540 ! results in movement of neuron [Term] id: GO:0001767 name: establishment of lymphocyte polarity namespace: biological_process def: "The directed orientation of lymphocyte signaling molecules and associated membrane rafts towards a chemokine gradient or a contact point with an appropriate activating cell." [GOC:mgi_curators, PMID:11244041, PMID:12615889] synonym: "lymphocyte polarization" EXACT [] is_a: BFO:0000003 is_a: GO:0030010 ! establishment of cell polarity intersection_of: GO:0030010 ! establishment of cell polarity intersection_of: BFO:0000066 CL:0000542 ! occurs in lymphocyte relationship: BFO:0000050 GO:0046649 ! part of lymphocyte activation relationship: BFO:0000066 CL:0000542 ! occurs in lymphocyte [Term] id: GO:0001768 name: establishment of T cell polarity namespace: biological_process def: "The directed orientation of T cell signaling molecules and associated membrane rafts towards a chemokine gradient or a contact point with antigen presenting cell." [GOC:mgi_curators, PMID:11244041, PMID:12615889] synonym: "establishment of T lymphocyte polarity" EXACT [] synonym: "establishment of T-cell polarity" EXACT [] synonym: "establishment of T-lymphocyte polarity" EXACT [] synonym: "T cell polarization" EXACT [] synonym: "T lymphocyte polarization" EXACT [] synonym: "T-cell polarization" EXACT [] is_a: GO:0001767 ! establishment of lymphocyte polarity intersection_of: GO:0030010 ! establishment of cell polarity intersection_of: BFO:0000066 CL:0000084 ! occurs in T cell relationship: BFO:0000050 GO:0042110 ! part of T cell activation relationship: BFO:0000066 CL:0000084 ! occurs in T cell [Term] id: GO:0001769 name: establishment of B cell polarity namespace: biological_process def: "The directed orientation of B cell signaling molecules and associated membrane rafts towards a chemokine gradient of a contact point with an antigen displaying cell." [GOC:mgi_curators, PMID:12615889, PMID:9692889] comment: Note that 'antigen displaying cell' in this term encompasses cell types such as follicular dendritic cells which display the unprocessed antigens of a B cell, leading to activation of the B cells and antigen uptake and processing by the B cells. synonym: "B cell polarization" EXACT [] synonym: "B lymphocyte polarization" EXACT [] synonym: "B-cell polarization" EXACT [] synonym: "establishment of B lymphocyte polarity" EXACT [] synonym: "establishment of B-cell polarity" EXACT [] synonym: "establishment of B-lymphocyte polarity" EXACT [] is_a: GO:0001767 ! establishment of lymphocyte polarity intersection_of: GO:0030010 ! establishment of cell polarity intersection_of: BFO:0000066 CL:0000236 ! occurs in B cell relationship: BFO:0000050 GO:0042113 ! part of B cell activation relationship: BFO:0000066 CL:0000236 ! occurs in B cell [Term] id: GO:0001770 name: establishment of natural killer cell polarity namespace: biological_process def: "The directed orientation of natural killer cell signaling molecules and associated membrane rafts towards a chemokine gradient or a contact point with a cell displaying natural killer cell activating ligands." [GOC:mgi_curators, PMID:12615886, PMID:9759849] synonym: "establishment of NK cell polarity" EXACT [] synonym: "natural killer cell polarization" EXACT [] synonym: "NK cell polarization" EXACT [] is_a: GO:0001767 ! establishment of lymphocyte polarity intersection_of: GO:0030010 ! establishment of cell polarity intersection_of: BFO:0000066 CL:0000623 ! occurs in natural killer cell relationship: BFO:0000050 GO:0030101 ! part of natural killer cell activation relationship: BFO:0000066 CL:0000623 ! occurs in natural killer cell [Term] id: GO:0001773 name: myeloid dendritic cell activation namespace: biological_process def: "The change in morphology and behavior of a dendritic cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor." [GOC:mgi_curators, ISBN:0781735149] is_a: GO:0002274 ! myeloid leukocyte activation intersection_of: GO:0001775 ! cell activation intersection_of: RO:0004009 CL:0000782 ! has primary input myeloid dendritic cell relationship: RO:0004009 CL:0000782 ! has primary input myeloid dendritic cell [Term] id: GO:0001774 name: microglial cell activation namespace: biological_process def: "The change in morphology and behavior of a microglial cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor." [GOC:mgi_curators, PMID:10626665, PMID:10695728, PMID:12580336, PMID:9893949] is_a: GO:0002269 ! leukocyte activation involved in inflammatory response is_a: GO:0042116 ! macrophage activation is_a: GO:0061900 ! glial cell activation intersection_of: GO:0001775 ! cell activation intersection_of: RO:0004009 CL:0000129 ! has primary input microglial cell relationship: RO:0004009 CL:0000129 ! has primary input microglial cell [Term] id: GO:0001775 name: cell activation namespace: biological_process def: "A multicellular organismal process by which exposure to an activating factor such as a cellular or soluble ligand results in a change in the morphology or behavior of a cell." [GOC:mgi_curators] subset: goslim_pir is_a: GO:0009987 ! cellular process is_a: GO:0032501 ! multicellular organismal process relationship: RO:0002162 NCBITaxon:33208 ! in taxon Metazoa property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/24416" xsd:anyURI [Term] id: GO:0001776 name: leukocyte homeostasis namespace: biological_process def: "The process of regulating the proliferation and elimination of cells of the immune system such that the total number of cells of a particular cell type within a whole or part of an organism is stable over time in the absence of an outside stimulus." [GOC:add, ISBN:0781735149] comment: Note that this term represents the return of immune system cell levels to stable numbers following an immune response as well as the proliferation and elimination of cells of the immune system required to maintain stable numbers in the absence of an outside stimulus. synonym: "immune cell homeostasis" EXACT [] synonym: "leucocyte homeostasis" EXACT [] is_a: BFO:0000003 is_a: GO:0002376 ! immune system process is_a: GO:0048872 ! homeostasis of number of cells intersection_of: GO:0048872 ! homeostasis of number of cells intersection_of: RO:0012003 CL:0000738 ! acts on population of leukocyte relationship: RO:0002162 NCBITaxon:7742 ! in taxon Vertebrata relationship: RO:0012003 CL:0000738 ! acts on population of leukocyte [Term] id: GO:0001777 name: T cell homeostatic proliferation namespace: biological_process def: "The non-specific expansion of T cell populations within a whole or part of an organism to reach to a total number of T cells which will then remain stable over time in the absence of an external stimulus." [GOC:mgi_curators, ISBN:0781735149] synonym: "resting T cell proliferation" EXACT [] synonym: "resting T-cell proliferation" EXACT [] synonym: "T lymphocyte homeostatic proliferation" EXACT [] synonym: "T-cell homeostatic proliferation" EXACT [] synonym: "T-lymphocyte homeostatic proliferation" EXACT [] is_a: GO:0042098 ! T cell proliferation intersection_of: GO:0008283 ! cell population proliferation intersection_of: BFO:0000050 GO:0042592 ! part of homeostatic process intersection_of: RO:0012003 CL:0000084 ! acts on population of T cell relationship: BFO:0000050 GO:0043029 ! part of T cell homeostasis [Term] id: GO:0001779 name: natural killer cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires the specialized features of a natural killer cell." [GOC:add, ISBN:0781735149] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "natural killer cell development" RELATED [GOC:add] synonym: "NK cell differentiation" EXACT [] is_a: GO:0030098 ! lymphocyte differentiation is_a: GO:0030101 ! natural killer cell activation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000623 ! results in acquisition of features of natural killer cell relationship: RO:0002315 CL:0000623 ! results in acquisition of features of natural killer cell [Term] id: GO:0001780 name: neutrophil homeostasis namespace: biological_process def: "The process of regulating the proliferation and elimination of neutrophils such that the total number of neutrophils within a whole or part of an organism is stable over time in the absence of an outside stimulus." [GOC:add, GOC:pr, PMID:12752675, PMID:12960266] comment: Note that this term represents the return of neutrophil levels to stable numbers following an immune response as well as the proliferation and elimination of neutrophils required to maintain stable numbers in the absence of an outside stimulus. is_a: GO:0001776 ! leukocyte homeostasis is_a: GO:0002262 ! myeloid cell homeostasis intersection_of: GO:0048872 ! homeostasis of number of cells intersection_of: RO:0012003 CL:0000775 ! acts on population of neutrophil relationship: RO:0012003 CL:0000775 ! acts on population of neutrophil [Term] id: GO:0001781 name: neutrophil apoptotic process namespace: biological_process def: "Any apoptotic process in a neutrophil, any of the immature or mature forms of a granular leukocyte that in its mature form has a nucleus with three to five lobes connected by slender threads of chromatin, and cytoplasm containing fine inconspicuous granules and stainable by neutral dyes." [CL:0000775, GOC:add, GOC:mtg_apoptosis, PMID:12752675, PMID:12960266] synonym: "apoptosis of neutrophils" EXACT [] synonym: "neutrophil apoptosis" NARROW [] synonym: "neutrophil programmed cell death by apoptosis" EXACT [] synonym: "programmed cell death of neutrophils by apoptosis" EXACT [] synonym: "programmed cell death, neutrophils" EXACT [] is_a: GO:0006925 ! inflammatory cell apoptotic process is_a: GO:0033028 ! myeloid cell apoptotic process is_a: GO:0071887 ! leukocyte apoptotic process intersection_of: GO:0006915 ! apoptotic process intersection_of: BFO:0000066 CL:0000775 ! occurs in neutrophil relationship: BFO:0000050 GO:0001780 ! part of neutrophil homeostasis relationship: BFO:0000066 CL:0000775 ! occurs in neutrophil [Term] id: GO:0001782 name: B cell homeostasis namespace: biological_process def: "The process of regulating the proliferation and elimination of B cells such that the total number of B cells within a whole or part of an organism is stable over time in the absence of an outside stimulus." [GOC:add, ISBN:0781735149, PMID:12956429] comment: Note that this term represents the return of B cell levels to stable numbers following an immune response as well as the proliferation and elimination of B cells required to maintain stable numbers in the absence of an outside stimulus. synonym: "B lymphocyte homeostasis" EXACT [] synonym: "B-cell homeostasis" EXACT [] synonym: "B-lymphocyte homeostasis" EXACT [] is_a: GO:0002260 ! lymphocyte homeostasis intersection_of: GO:0048872 ! homeostasis of number of cells intersection_of: RO:0012003 CL:0000236 ! acts on population of B cell relationship: RO:0012003 CL:0000236 ! acts on population of B cell [Term] id: GO:0001783 name: B cell apoptotic process namespace: biological_process def: "Any apoptotic process in a B cell, a lymphocyte of B lineage with the phenotype CD19-positive and capable of B cell mediated immunity." [CL:0000236, GOC:add, GOC:mtg_apoptosis, ISBN:0781735149] synonym: "apoptosis of B cells" EXACT [] synonym: "apoptosis of B lymphocytes" EXACT [] synonym: "apoptosis of B-cells" EXACT [] synonym: "apoptosis of B-lymphocytes" EXACT [] synonym: "B cell apoptosis" NARROW [] synonym: "B cell programmed cell death by apoptosis" EXACT [] synonym: "B lymphocyte apoptosis" EXACT [] synonym: "B lymphocyte programmed cell death by apoptosis" EXACT [] synonym: "B-cell apoptosis" EXACT [] synonym: "B-cell programmed cell death by apoptosis" EXACT [] synonym: "B-lymphocyte apoptosis" EXACT [] synonym: "B-lymphocyte programmed cell death by apoptosis" EXACT [] synonym: "programmed cell death of B cells by apoptosis" EXACT [] synonym: "programmed cell death of B lymphocytes by apoptosis" EXACT [] synonym: "programmed cell death of B-cells by apoptosis" EXACT [] synonym: "programmed cell death of B-lymphocytes by apoptosis" EXACT [] synonym: "programmed cell death, B cells" EXACT [] synonym: "programmed cell death, B lymphocytes" EXACT [] synonym: "programmed cell death, B-cells" EXACT [] synonym: "programmed cell death, B-lymphocytes" EXACT [] is_a: GO:0070227 ! lymphocyte apoptotic process intersection_of: GO:0006915 ! apoptotic process intersection_of: BFO:0000066 CL:0000236 ! occurs in B cell relationship: BFO:0000066 CL:0000236 ! occurs in B cell [Term] id: GO:0001787 name: natural killer cell proliferation namespace: biological_process def: "The expansion of a natural killer cell population by cell division." [GOC:add, ISBN:0781735149] synonym: "NK cell proliferation" EXACT [] is_a: GO:0030101 ! natural killer cell activation is_a: GO:0046651 ! lymphocyte proliferation intersection_of: GO:0008283 ! cell population proliferation intersection_of: RO:0012003 CL:0000623 ! acts on population of natural killer cell relationship: RO:0012003 CL:0000623 ! acts on population of natural killer cell [Term] id: GO:0001816 name: cytokine production namespace: biological_process def: "The appearance of a cytokine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:add, ISBN:0781735149] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms. subset: gocheck_do_not_annotate subset: goslim_pir synonym: "cytokine biosynthetic process" NARROW [] synonym: "cytokine metabolic process" NARROW [] synonym: "cytokine secretion" NARROW [] synonym: "interferon production" NARROW [GOC:add, GOC:mah] synonym: "interferon secretion" NARROW [GOC:add, GOC:mah] synonym: "interleukin production" NARROW [GOC:add, GOC:mah, http://wiki.geneontology.org/index.php/Why_isn%27t_interleukin_in_GO%3F] synonym: "interleukin secretion" NARROW [GOC:add, GOC:mah, http://wiki.geneontology.org/index.php/Why_isn%27t_interleukin_in_GO%3F] is_a: GO:0010467 ! gene expression is_a: GO:0032501 ! multicellular organismal process property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/19116" xsd:anyURI property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0001817 name: regulation of cytokine production namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of production of a cytokine." [GOC:add, ISBN:0781735149] synonym: "regulation of cytokine anabolism" EXACT [] synonym: "regulation of cytokine biosynthesis" EXACT [] synonym: "regulation of cytokine biosynthetic process" NARROW [] synonym: "regulation of cytokine formation" EXACT [] synonym: "regulation of cytokine secretion" NARROW [] synonym: "regulation of cytokine synthesis" EXACT [] is_a: GO:0010468 ! regulation of gene expression is_a: GO:0051239 ! regulation of multicellular organismal process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0001816 ! regulates cytokine production relationship: RO:0002211 GO:0001816 ! regulates cytokine production property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0001818 name: negative regulation of cytokine production namespace: biological_process def: "Any process that stops, prevents, or reduces the rate of production of a cytokine." [GOC:add, ISBN:0781735149] synonym: "down regulation of cytokine biosynthetic process" EXACT [] synonym: "down regulation of cytokine production" EXACT [] synonym: "down-regulation of cytokine biosynthetic process" EXACT [] synonym: "down-regulation of cytokine production" EXACT [] synonym: "downregulation of cytokine biosynthetic process" EXACT [] synonym: "downregulation of cytokine production" EXACT [] synonym: "inhibition of cytokine biosynthetic process" NARROW [] synonym: "inhibition of cytokine production" NARROW [] synonym: "negative regulation of cytokine anabolism" EXACT [] synonym: "negative regulation of cytokine biosynthesis" EXACT [] synonym: "negative regulation of cytokine biosynthetic process" NARROW [] synonym: "negative regulation of cytokine formation" EXACT [] synonym: "negative regulation of cytokine secretion" NARROW [] synonym: "negative regulation of cytokine synthesis" EXACT [] is_a: GO:0001817 ! regulation of cytokine production is_a: GO:0010629 ! negative regulation of gene expression is_a: GO:0051241 ! negative regulation of multicellular organismal process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0001816 ! negatively regulates cytokine production relationship: RO:0002212 GO:0001816 ! negatively regulates cytokine production property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0001819 name: positive regulation of cytokine production namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of production of a cytokine." [GOC:add, ISBN:0781735149] synonym: "activation of cytokine production" NARROW [] synonym: "positive regulation of cytokine biosynthetic process" NARROW [] synonym: "positive regulation of cytokine secretion" NARROW [] synonym: "stimulation of cytokine production" NARROW [] synonym: "up regulation of cytokine production" EXACT [] synonym: "up-regulation of cytokine production" EXACT [] synonym: "upregulation of cytokine production" EXACT [] is_a: GO:0001817 ! regulation of cytokine production is_a: GO:0010628 ! positive regulation of gene expression is_a: GO:0051240 ! positive regulation of multicellular organismal process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0001816 ! positively regulates cytokine production relationship: RO:0002213 GO:0001816 ! positively regulates cytokine production property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0001820 name: serotonin secretion namespace: biological_process def: "The regulated release of serotonin by a cell. Serotonin (5-hydroxytryptamine, or 5-HT) is a monoamine synthesized in serotonergic neurons in the central nervous system, enterochromaffin cells in the gastrointestinal tract and some immune system cells." [GOC:ef, ISBN:0198506732, ISBN:0781735149] synonym: "5-HT secretion" EXACT [] synonym: "5-hydroxytryptamine secretion" EXACT [] synonym: "serotonin release" RELATED [GOC:tb] is_a: GO:0006837 ! serotonin transport is_a: GO:0023061 ! signal release intersection_of: GO:0046903 ! secretion intersection_of: RO:0004009 CHEBI:350546 ! has primary input [Term] id: GO:0001821 name: histamine secretion namespace: biological_process def: "The regulated release of histamine by a cell or tissue. It is formed by decarboxylation of histidine and it acts through receptors in smooth muscle and in secretory systems." [GOC:mah, ISBN:0198506732, ISBN:0781735149] is_a: GO:0046903 ! secretion is_a: GO:0051608 ! histamine transport intersection_of: GO:0046903 ! secretion intersection_of: RO:0004009 CHEBI:58432 ! has primary input [Term] id: GO:0001822 name: kidney development namespace: biological_process def: "The process whose specific outcome is the progression of the kidney over time, from its formation to the mature structure. The kidney is an organ that filters the blood and/or excretes the end products of body metabolism in the form of urine." [GOC:dph, GOC:mtg_kidney_jan10, ISBN:0124020607, ISBN:0721662544] synonym: "nephrogenesis" RELATED [GOC:rph] xref: Reactome:R-HSA-9830369 "Kidney development" xref: Wikipedia:Kidney_development is_a: GO:0048513 ! animal organ development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0002113 ! results in development of kidney relationship: BFO:0000050 GO:0072001 ! part of renal system development relationship: RO:0002162 NCBITaxon:7776 ! in taxon Gnathostomata relationship: RO:0002296 UBERON:0002113 ! results in development of kidney [Term] id: GO:0001823 name: mesonephros development namespace: biological_process def: "The process whose specific outcome is the progression of the mesonephros over time, from its formation to the mature structure. In mammals, the mesonephros is the second of the three embryonic kidneys to be established and exists only transiently. In lower vertebrates such as fish and amphibia, the mesonephros will form the mature kidney." [GOC:dph, ISBN:0124020607, ISBN:0721662544, PMID:10535314] synonym: "Wolffian body development" EXACT [GOC:dph] is_a: GO:0001822 ! kidney development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0000080 ! results in development of mesonephros relationship: RO:0002296 UBERON:0000080 ! results in development of mesonephros [Term] id: GO:0001824 name: blastocyst development namespace: biological_process def: "The process whose specific outcome is the progression of the blastocyst over time, from its formation to the mature structure. The mammalian blastocyst is a hollow ball of cells containing two cell types, the inner cell mass and the trophectoderm. The blastula follows the morula and precedes the gastrula in the developmental sequence." [GOC:dph, ISBN:0124020607, ISBN:0198542771] comment: See also the Anatomical Dictionary for Mouse Development ontology terms 'TS5, embryo ; EMAP:23', 'TS5, inner cell mass ; EMAP:24' and 'TS5, trophectoderm; EMAP:28'. synonym: "blastula development" RELATED [] is_a: GO:0048856 ! anatomical structure development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0000358 ! results in development of blastocyst relationship: BFO:0000050 GO:0001701 ! part of in utero embryonic development relationship: RO:0002296 UBERON:0000358 ! results in development of blastocyst property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/29162" xsd:anyURI [Term] id: GO:0001825 name: blastocyst formation namespace: biological_process def: "The initial formation of a blastocyst from a solid ball of cells known as a morula." [GOC:dph, ISBN:0124020607, ISBN:0198542771] comment: See also the Anatomical Dictionary for Mouse Development ontology term 'TS3, compacted morula ; EMAP:9'. synonym: "blastula formation" RELATED [] is_a: BFO:0000003 is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0000358 ! results in formation of anatomical entity blastocyst relationship: BFO:0000050 GO:0001824 ! part of blastocyst development relationship: RO:0002297 UBERON:0000358 ! results in formation of anatomical entity blastocyst property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/29162" xsd:anyURI [Term] id: GO:0001826 name: inner cell mass cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of an inner cell mass cell." [GOC:dph, ISBN:0124020607, ISBN:0198542771] comment: See also the Anatomical Dictionary for Mouse Development ontology terms 'TS4, inner cell mass ; EMAP:14'. is_a: GO:0030154 ! cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:2000020 ! results in acquisition of features of inner cell mass cell relationship: BFO:0000050 GO:0001825 ! part of blastocyst formation relationship: RO:0002315 CL:2000020 ! results in acquisition of features of inner cell mass cell [Term] id: GO:0001829 name: trophectodermal cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires the specialized features of a trophectoderm cell." [GOC:dph, ISBN:0124020607, ISBN:0198542771] comment: See also the Anatomical Dictionary for Mouse Development ontology terms 'TS4, trophectoderm ; EMAP:19'. synonym: "trophectoderm cell differentiation" EXACT [] is_a: GO:0030154 ! cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:1000274 ! results in acquisition of features of trophectodermal cell relationship: BFO:0000050 GO:0001825 ! part of blastocyst formation relationship: RO:0002315 CL:1000274 ! results in acquisition of features of trophectodermal cell [Term] id: GO:0001831 name: trophectodermal cellular morphogenesis namespace: biological_process def: "The morphogenesis of trophectoderm cells." [GOC:dph, ISBN:0124020607, ISBN:0198542771] comment: See also the Anatomical Dictionary for Mouse Development ontology terms 'TS4, trophectoderm ; EMAP:19', 'TS5, trophectoderm ; EMAP:28' and 'TS6, trophectoderm ; EMAP:39'. synonym: "trophectoderm cellular morphogenesis" EXACT [] is_a: GO:0000902 ! cell morphogenesis is_a: GO:0048598 ! embryonic morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 CL:1000274 ! results in morphogenesis of trophectodermal cell relationship: BFO:0000050 GO:0001829 ! part of trophectodermal cell differentiation relationship: RO:0002298 CL:1000274 ! results in morphogenesis of trophectodermal cell [Term] id: GO:0001832 name: blastocyst growth namespace: biological_process def: "An increase in size of a blastocyst due to expansion of the blastocoelic cavity cell shape changes and cell proliferation." [GOC:dph, ISBN:0124020607, ISBN:0198542771] comment: See also the Anatomical Dictionary for Mouse Development ontology terms 'TS4, blastocoelic cavity ; EMAP:17', 'TS5, blastocoelic cavity ; EMAP:27' and 'TS6, blastocoelic cavity ; EMAP:36'. synonym: "blastula growth" RELATED [] is_a: BFO:0000003 is_a: GO:0048589 ! developmental growth intersection_of: GO:0040007 ! growth intersection_of: RO:0002343 UBERON:0000358 ! results in growth of blastocyst relationship: BFO:0000050 GO:0001824 ! part of blastocyst development relationship: RO:0002343 UBERON:0000358 ! results in growth of blastocyst property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/29162" xsd:anyURI [Term] id: GO:0001833 name: inner cell mass cell proliferation namespace: biological_process def: "The proliferation of cells in the inner cell mass." [GOC:dph, GOC:isa_complete, ISBN:0124020607, ISBN:0198542771] comment: See also the Anatomical Dictionary for Mouse Development ontology terms 'TS4, inner cell mass ; EMAP:14' and 'TS5, inner cell mass ; EMAP:24'. is_a: BFO:0000003 is_a: GO:0008283 ! cell population proliferation intersection_of: GO:0008283 ! cell population proliferation intersection_of: RO:0012003 CL:2000020 ! acts on population of inner cell mass cell relationship: BFO:0000050 GO:0001832 ! part of blastocyst growth relationship: RO:0012003 CL:2000020 ! acts on population of inner cell mass cell [Term] id: GO:0001834 name: trophectodermal cell proliferation namespace: biological_process def: "The proliferation of cells in the trophectoderm." [GOC:dph, ISBN:0124020607, ISBN:0198542771] comment: See also the Anatomical Dictionary for Mouse Development ontology terms 'TS4, trophectoderm ; EMAP:19', 'TS5, trophectoderm ; EMAP:28' and 'TS6, trophectoderm ; EMAP:39'. synonym: "trophectoderm cell proliferation" EXACT [] is_a: BFO:0000003 is_a: GO:0008283 ! cell population proliferation intersection_of: GO:0008283 ! cell population proliferation intersection_of: RO:0012003 CL:1000274 ! acts on population of trophectodermal cell relationship: BFO:0000050 GO:0001832 ! part of blastocyst growth relationship: RO:0012003 CL:1000274 ! acts on population of trophectodermal cell [Term] id: GO:0001837 name: epithelial to mesenchymal transition namespace: biological_process def: "A transition where an epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell." [GOC:dph, PMID:14701881] synonym: "EMT" EXACT [] synonym: "epithelial-mesenchymal transition" EXACT [] synonym: "mesenchymal cell differentiation from epithelial cell" EXACT [GOC:BHF, GOC:dph, GOC:rl] xref: Reactome:R-HSA-9758919 "Epithelial-Mesenchymal Transition (EMT) during gastrulation" is_a: GO:0048762 ! mesenchymal cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0008019 ! results in acquisition of features of mesenchymal cell intersection_of: RO:0004009 CL:0000066 ! has primary input epithelial cell relationship: RO:0004009 CL:0000066 ! has primary input epithelial cell [Term] id: GO:0001838 name: embryonic epithelial tube formation namespace: biological_process def: "The morphogenesis of an embryonic epithelium into a tube-shaped structure." [GOC:dph, ISBN:0824072820] is_a: GO:0072175 ! epithelial tube formation relationship: BFO:0000050 GO:0016331 ! part of morphogenesis of embryonic epithelium [Term] id: GO:0001839 name: neural plate morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the neural plate are generated and organized. The neural plate is a specialized region of columnar epithelial cells in the dorsal ectoderm that will give rise to nervous system tissue." [GOC:dph, ISBN:0878932437] is_a: GO:0016331 ! morphogenesis of embryonic epithelium intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0003075 ! results in morphogenesis of neural plate relationship: BFO:0000050 GO:0001840 ! part of neural plate development relationship: RO:0002298 UBERON:0003075 ! results in morphogenesis of neural plate [Term] id: GO:0001840 name: neural plate development namespace: biological_process def: "The process whose specific outcome is the progression of the neural plate over time, from its formation to the mature structure. The neural plate is a flat, thickened layer of ectodermal cells. The underlying dorsal mesoderm signals the ectodermal cells above it to elongate into columnar neural plate cells. The neural plate subsequently develops into the neural tube, which gives rise to the central nervous system." [GOC:dph, GOC:ef, ISBN:0878932437, ISBN:0878932585] is_a: GO:0060429 ! epithelium development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0003075 ! results in development of neural plate relationship: BFO:0000050 GO:0043009 ! part of chordate embryonic development relationship: RO:0002296 UBERON:0003075 ! results in development of neural plate [Term] id: GO:0001841 name: neural tube formation namespace: biological_process def: "The formation of a tube from the flat layer of ectodermal cells known as the neural plate. This will give rise to the central nervous system." [GOC:dph, ISBN:0878932437] synonym: "neural tube morphogenesis" EXACT [GOC:dph] synonym: "neurulation" EXACT [] xref: Wikipedia:Neurulation is_a: GO:0001838 ! embryonic epithelial tube formation intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0001049 ! results in formation of anatomical entity neural tube relationship: BFO:0000050 GO:0021915 ! part of neural tube development relationship: RO:0002297 UBERON:0001049 ! results in formation of anatomical entity neural tube [Term] id: GO:0001842 name: neural fold formation namespace: biological_process def: "The process in which the neural fold is formed. The edges of the neural plate thicken and move up to form a U-shaped structure called the neural groove." [GOC:dph, ISBN:0878932437] synonym: "neural groove formation" RELATED [GOC:dph] is_a: GO:0016331 ! morphogenesis of embryonic epithelium is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis is_a: GO:0060571 ! morphogenesis of an epithelial fold intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0005062 ! results in formation of anatomical entity neural fold relationship: BFO:0000050 GO:0014020 ! part of primary neural tube formation relationship: RO:0002297 UBERON:0005062 ! results in formation of anatomical entity neural fold [Term] id: GO:0001865 name: NK T cell differentiation namespace: biological_process def: "The process in which a precursor cell type acquires the specialized features of a NK T cell." [GOC:add, ISBN:0781735149, PMID:10704459] comment: Note that NK T cells are a distinct lineage of T cells expressing natural killer cell markers and having T cell receptors characterized by the usage of a restricted repertoire of variable region gene segments. Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "natural killer T cell differentiation" EXACT [] synonym: "natural T cell differentiation" EXACT [] synonym: "NK T cell development" RELATED [GOC:add] synonym: "NK T lymphocyte differentiation" EXACT [] synonym: "NK T-cell differentiation" EXACT [] synonym: "NK T-lymphocyte differentiation" EXACT [] synonym: "NKT cell differentiation" EXACT [] synonym: "NT cell differentiation" EXACT [] is_a: GO:0046632 ! alpha-beta T cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000814 ! results in acquisition of features of mature NK T cell relationship: RO:0002162 NCBITaxon:7776 ! in taxon Gnathostomata relationship: RO:0002315 CL:0000814 ! results in acquisition of features of mature NK T cell [Term] id: GO:0001866 name: NK T cell proliferation namespace: biological_process def: "The expansion of a NK T cell population by cell division." [GOC:add, ISBN:0781735149, PMID:10704459] comment: Note that NK T cells are a distinct lineage of T cells expressing natural killer cell markers and having T cell receptors characterized by the usage of a restricted repertoire of variable region gene segments. synonym: "natural killer T cell proliferation" EXACT [] synonym: "natural T cell proliferation" EXACT [] synonym: "NK T lymphocyte proliferation" EXACT [] synonym: "NK T-cell proliferation" EXACT [] synonym: "NK T-lymphocyte proliferation" EXACT [] synonym: "NKT cell proliferation" EXACT [] synonym: "NT cell proliferation" EXACT [] is_a: GO:0046633 ! alpha-beta T cell proliferation is_a: GO:0051132 ! NK T cell activation intersection_of: GO:0008283 ! cell population proliferation intersection_of: RO:0012003 CL:0000814 ! acts on population of mature NK T cell relationship: RO:0012003 CL:0000814 ! acts on population of mature NK T cell [Term] id: GO:0001873 name: polysaccharide immune receptor activity namespace: molecular_function def: "Combining with a polysaccharide and transmitting the signal to initiate an innate immune response. A polysaccharide is a polymer of many (typically more than 10) monosaccharide residues linked glycosidically." [PMID:14707091] synonym: "polysaccharide receptor activity" BROAD [] is_a: BFO:0000003 is_a: GO:0038187 ! pattern recognition receptor activity intersection_of: GO:0038023 ! signaling receptor activity intersection_of: RO:0004009 CHEBI:18154 ! has primary input relationship: BFO:0000051 GO:0030247 ! has part polysaccharide binding relationship: RO:0004009 CHEBI:18154 ! has primary input [Term] id: GO:0001885 name: endothelial cell development namespace: biological_process def: "The progression of an endothelial cell over time, from its formation to the mature structure." [GOC:dph] is_a: GO:0002064 ! epithelial cell development intersection_of: GO:0032502 ! developmental process intersection_of: RO:0002296 CL:0000115 ! results in development of endothelial cell relationship: BFO:0000050 GO:0045446 ! part of endothelial cell differentiation relationship: RO:0002296 CL:0000115 ! results in development of endothelial cell [Term] id: GO:0001886 name: endothelial cell morphogenesis namespace: biological_process def: "The change in form (cell shape and size) that occurs during the differentiation of an endothelial cell." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0003382 ! epithelial cell morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 CL:0000115 ! results in morphogenesis of endothelial cell relationship: BFO:0000050 GO:0001885 ! part of endothelial cell development relationship: RO:0002298 CL:0000115 ! results in morphogenesis of endothelial cell [Term] id: GO:0001889 name: liver development namespace: biological_process def: "The process whose specific outcome is the progression of the liver over time, from its formation to the mature structure. The liver is an exocrine gland which secretes bile and functions in metabolism of protein and carbohydrate and fat, synthesizes substances involved in the clotting of the blood, synthesizes vitamin A, detoxifies poisonous substances, stores glycogen, and breaks down worn-out erythrocytes." [GOC:add, ISBN:068340007X] is_a: GO:0048732 ! gland development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0002107 ! results in development of liver relationship: BFO:0000050 GO:0061008 ! part of hepaticobiliary system development relationship: RO:0002296 UBERON:0002107 ! results in development of liver [Term] id: GO:0001890 name: placenta development namespace: biological_process def: "The process whose specific outcome is the progression of the placenta over time, from its formation to the mature structure. The placenta is an organ of metabolic interchange between fetus and mother, partly of embryonic origin and partly of maternal origin." [GOC:add, ISBN:068340007X] synonym: "placental development" EXACT [] synonym: "placentation" EXACT [GOC:dph, GOC:tb] is_a: GO:0048513 ! animal organ development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0001987 ! results in development of placenta relationship: RO:0002162 NCBITaxon:32525 ! in taxon Theria relationship: RO:0002296 UBERON:0001987 ! results in development of placenta [Term] id: GO:0001892 name: embryonic placenta development namespace: biological_process def: "The embryonically driven process whose specific outcome is the progression of the placenta over time, from its formation to the mature structure. The placenta is an organ of metabolic interchange between fetus and mother, partly of embryonic origin and partly of maternal origin." [GOC:add, ISBN:068340007X] synonym: "fetal placenta development" EXACT [GOC:dph] is_a: GO:0048568 ! embryonic organ development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0007106 ! results in development of chorionic villus relationship: BFO:0000050 GO:0001701 ! part of in utero embryonic development relationship: BFO:0000050 GO:0001890 ! part of placenta development relationship: RO:0002296 UBERON:0007106 ! results in development of chorionic villus [Term] id: GO:0001893 name: maternal placenta development namespace: biological_process def: "Maternally driven process whose specific outcome is the progression of the placenta over time, from its formation to the mature structure. The placenta is an organ of metabolic interchange between fetus and mother, partly of embryonic origin and partly of maternal origin." [GOC:add, ISBN:068340007X] synonym: "decidua development" RELATED [GOC:dph] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0048856 ! anatomical structure development is_a: GO:0060135 ! maternal process involved in female pregnancy intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0002450 ! results in development of decidua relationship: BFO:0000050 GO:0001890 ! part of placenta development relationship: RO:0002296 UBERON:0002450 ! results in development of decidua [Term] id: GO:0001894 name: tissue homeostasis namespace: biological_process def: "A homeostatic process involved in the maintenance of an internal steady state within a defined tissue of an organism, including control of cellular proliferation and death and control of metabolic function." [GOC:add, GOC:isa_complete] synonym: "tissue maintenance" NARROW [GOC:add] is_a: GO:0060249 ! anatomical structure homeostasis relationship: BFO:0000050 GO:0048871 ! part of multicellular organismal-level homeostasis property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0001906 name: cell killing namespace: biological_process def: "Any process in an organism that results in the killing of its own cells or those of another organism, including in some cases the death of the other organism. Killing here refers to the induction of death in one cell by another cell, not cell-autonomous death due to internal or other environmental conditions." [GOC:add] subset: goslim_pir synonym: "necrosis" RELATED [] is_a: GO:0009987 ! cellular process disjoint_from: GO:0044848 ! biological phase [Term] id: GO:0001909 name: leukocyte mediated cytotoxicity namespace: biological_process def: "The directed killing of a target cell by a leukocyte." [GO_REF:0000022, GOC:add, ISBN:0781735149, PMID:11911826] comment: Note that this term and its children describe contact-dependent killing of target cells by lymphocytes and myeloid cells of the immune system. synonym: "immune cell mediated cell death" EXACT [] synonym: "immune cell mediated cell killing" EXACT [] synonym: "immune cell mediated cytotoxicity" EXACT [] synonym: "leucocyte mediated cytotoxicity" EXACT [] is_a: GO:0001906 ! cell killing is_a: GO:0002443 ! leukocyte mediated immunity intersection_of: GO:0001906 ! cell killing intersection_of: RO:0002608 CL:0000738 ! process has causal agent leukocyte [Term] id: GO:0001910 name: regulation of leukocyte mediated cytotoxicity namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of leukocyte mediated cytotoxicity." [GOC:add, ISBN:0781735149, PMID:11911826] synonym: "regulation of immune cell mediated cell death" EXACT [] synonym: "regulation of immune cell mediated cell killing" EXACT [] synonym: "regulation of immune cell mediated cytotoxicity" EXACT [] synonym: "regulation of leucocyte mediated cytotoxicity" EXACT [] is_a: GO:0002703 ! regulation of leukocyte mediated immunity is_a: GO:0031341 ! regulation of cell killing intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0001909 ! regulates leukocyte mediated cytotoxicity relationship: RO:0002211 GO:0001909 ! regulates leukocyte mediated cytotoxicity [Term] id: GO:0001911 name: negative regulation of leukocyte mediated cytotoxicity namespace: biological_process def: "Any process that stops, prevents, or reduces the rate of leukocyte mediated cytotoxicity." [GOC:add, ISBN:0781735149, PMID:11911826] synonym: "down regulation of leukocyte mediated cytotoxicity" EXACT [] synonym: "down-regulation of leukocyte mediated cytotoxicity" EXACT [] synonym: "downregulation of leukocyte mediated cytotoxicity" EXACT [] synonym: "inhibition of leukocyte mediated cytotoxicity" NARROW [] synonym: "negative regulation of immune cell mediated cytotoxicity" EXACT [] synonym: "negative regulation of leucocyte mediated cytotoxicity" EXACT [] is_a: GO:0001910 ! regulation of leukocyte mediated cytotoxicity is_a: GO:0002704 ! negative regulation of leukocyte mediated immunity is_a: GO:0031342 ! negative regulation of cell killing intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0001909 ! negatively regulates leukocyte mediated cytotoxicity relationship: RO:0002212 GO:0001909 ! negatively regulates leukocyte mediated cytotoxicity [Term] id: GO:0001912 name: positive regulation of leukocyte mediated cytotoxicity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of leukocyte mediated cytotoxicity." [GOC:add, ISBN:0781735149, PMID:11911826] synonym: "activation of leukocyte mediated cytotoxicity" NARROW [] synonym: "positive regulation of immune cell mediated cytotoxicity" EXACT [] synonym: "positive regulation of leucocyte mediated cytotoxicity" EXACT [] synonym: "stimulation of leukocyte mediated cytotoxicity" NARROW [] synonym: "up regulation of leukocyte mediated cytotoxicity" EXACT [] synonym: "up-regulation of leukocyte mediated cytotoxicity" EXACT [] synonym: "upregulation of leukocyte mediated cytotoxicity" EXACT [] is_a: GO:0001910 ! regulation of leukocyte mediated cytotoxicity is_a: GO:0002705 ! positive regulation of leukocyte mediated immunity is_a: GO:0031343 ! positive regulation of cell killing intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0001909 ! positively regulates leukocyte mediated cytotoxicity relationship: RO:0002213 GO:0001909 ! positively regulates leukocyte mediated cytotoxicity [Term] id: GO:0001913 name: T cell mediated cytotoxicity namespace: biological_process def: "The directed killing of a target cell by a T cell through the release of granules containing cytotoxic mediators or through the engagement of death receptors." [GOC:add, GOC:pr, ISBN:0781735149, PMID:11911826] comment: Note that either or both mechanisms mentioned in the definition may be used in this process. Note that both granule release and the engagement of death receptors on target cells result in the induction of apoptosis in the target cell. Note that both CD4 and CD8 positive T cells can mediate apoptosis of target cells, independently of their definition as 'helper' T cells or not. synonym: "T cell mediated apoptosis" EXACT [] synonym: "T cell mediated cell death" EXACT [] synonym: "T cell mediated cell killing" EXACT [] synonym: "T cell mediated cytolysis" RELATED [] synonym: "T lymphocyte mediated cytotoxicity" EXACT [] synonym: "T-cell mediated apoptosis" EXACT [] synonym: "T-cell mediated cell death" EXACT [] synonym: "T-cell mediated cell killing" EXACT [] synonym: "T-cell mediated cytotoxicity" EXACT [] synonym: "T-lymphocyte mediated cytotoxicity" EXACT [] is_a: GO:0001909 ! leukocyte mediated cytotoxicity is_a: GO:0002456 ! T cell mediated immunity intersection_of: GO:0001906 ! cell killing intersection_of: RO:0002608 CL:0000084 ! process has causal agent T cell [Term] id: GO:0001914 name: regulation of T cell mediated cytotoxicity namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of T cell mediated cytotoxicity." [GOC:add, ISBN:0781735149] synonym: "regulation of T cell mediated apoptosis" EXACT [] synonym: "regulation of T cell mediated cell death" EXACT [] synonym: "regulation of T cell mediated cell killing" EXACT [] synonym: "regulation of T cell mediated cytolysis" RELATED [] synonym: "regulation of T lymphocyte mediated cytotoxicity" EXACT [] synonym: "regulation of T-cell mediated apoptosis" EXACT [] synonym: "regulation of T-cell mediated cell death" EXACT [] synonym: "regulation of T-cell mediated cell killing" EXACT [] synonym: "regulation of T-cell mediated cytolysis" RELATED [] synonym: "regulation of T-cell mediated cytotoxicity" EXACT [] synonym: "regulation of T-lymphocyte mediated cytotoxicity" EXACT [] is_a: GO:0001910 ! regulation of leukocyte mediated cytotoxicity is_a: GO:0002709 ! regulation of T cell mediated immunity intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0001913 ! regulates T cell mediated cytotoxicity relationship: RO:0002211 GO:0001913 ! regulates T cell mediated cytotoxicity [Term] id: GO:0001915 name: negative regulation of T cell mediated cytotoxicity namespace: biological_process def: "Any process that stops, prevents, or reduces the rate of T cell mediated cytotoxicity." [GOC:add, ISBN:0781735149] synonym: "down regulation of T cell mediated cytotoxicity" EXACT [] synonym: "down-regulation of T cell mediated cytotoxicity" EXACT [] synonym: "downregulation of T cell mediated cytotoxicity" EXACT [] synonym: "inhibition of T cell mediated cytotoxicity" NARROW [] synonym: "negative regulation of T cell mediated apoptosis" EXACT [] synonym: "negative regulation of T cell mediated cell death" EXACT [] synonym: "negative regulation of T cell mediated cell killing" EXACT [] synonym: "negative regulation of T cell mediated cytolysis" RELATED [] synonym: "negative regulation of T lymphocyte mediated cytotoxicity" EXACT [] synonym: "negative regulation of T-cell mediated apoptosis" EXACT [] synonym: "negative regulation of T-cell mediated cell death" EXACT [] synonym: "negative regulation of T-cell mediated cell killing" EXACT [] synonym: "negative regulation of T-cell mediated cytolysis" RELATED [] synonym: "negative regulation of T-cell mediated cytotoxicity" EXACT [] synonym: "negative regulation of T-lymphocyte mediated cytotoxicity" EXACT [] is_a: GO:0001911 ! negative regulation of leukocyte mediated cytotoxicity is_a: GO:0001914 ! regulation of T cell mediated cytotoxicity is_a: GO:0002710 ! negative regulation of T cell mediated immunity intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0001913 ! negatively regulates T cell mediated cytotoxicity relationship: RO:0002212 GO:0001913 ! negatively regulates T cell mediated cytotoxicity [Term] id: GO:0001916 name: positive regulation of T cell mediated cytotoxicity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of T cell mediated cytotoxicity." [GOC:add, ISBN:0781735149] synonym: "activation of T cell mediated cytotoxicity" NARROW [] synonym: "positive regulation of T cell mediated apoptosis" EXACT [] synonym: "positive regulation of T cell mediated cell death" EXACT [] synonym: "positive regulation of T cell mediated cell killing" EXACT [] synonym: "positive regulation of T cell mediated cytolysis" RELATED [] synonym: "positive regulation of T lymphocyte mediated cytotoxicity" EXACT [] synonym: "positive regulation of T-cell mediated apoptosis" EXACT [] synonym: "positive regulation of T-cell mediated cell death" EXACT [] synonym: "positive regulation of T-cell mediated cell killing" EXACT [] synonym: "positive regulation of T-cell mediated cytolysis" RELATED [] synonym: "positive regulation of T-cell mediated cytotoxicity" EXACT [] synonym: "positive regulation of T-lymphocyte mediated cytotoxicity" EXACT [] synonym: "stimulation of T cell mediated cytotoxicity" NARROW [] synonym: "up regulation of T cell mediated cytotoxicity" EXACT [] synonym: "up-regulation of T cell mediated cytotoxicity" EXACT [] synonym: "upregulation of T cell mediated cytotoxicity" EXACT [] is_a: GO:0001912 ! positive regulation of leukocyte mediated cytotoxicity is_a: GO:0001914 ! regulation of T cell mediated cytotoxicity is_a: GO:0002711 ! positive regulation of T cell mediated immunity intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0001913 ! positively regulates T cell mediated cytotoxicity relationship: RO:0002213 GO:0001913 ! positively regulates T cell mediated cytotoxicity [Term] id: GO:0001922 name: B-1 B cell homeostasis namespace: biological_process def: "The process of regulating the proliferation and elimination of B cells of the B-1 subset such that the total number of B-1 B cells within a whole or part of an organism is stable over time in the absence of an outside stimulus. B-1 B cells are a distinct subset of B cells characterized as being CD5 positive, found predominantly in the peritoneum, pleural cavities, and spleen, and enriched for self-reactivity." [GOC:add, ISBN:0781735149] comment: Note that this term represents the return of B-1 B cell levels to stable numbers following an immune response, as well as the proliferation and elimination of B-1 B cells in a organism required to maintain stable numbers in the absence of an outside stimulus. synonym: "B-1 B lymphocyte homeostasis" EXACT [] synonym: "B-1 B-cell homeostasis" EXACT [] synonym: "B-1 B-lymphocyte homeostasis" EXACT [] is_a: GO:0001782 ! B cell homeostasis intersection_of: GO:0048872 ! homeostasis of number of cells intersection_of: RO:0012003 CL:0000819 ! acts on population of B-1 B cell relationship: RO:0012003 CL:0000819 ! acts on population of B-1 B cell [Term] id: GO:0001923 name: B-1 B cell differentiation namespace: biological_process def: "The process in which a hemopoietic stem cell acquires the specialized features of a B-1 B cell. B-1 B cells are a distinct subset of B cells characterized as being CD5 positive, found predominantly in the peritoneum, pleural cavities, and spleen, and enriched for self-reactivity." [GOC:add, ISBN:0781735149] synonym: "B-1 B cell development" RELATED [GOC:add] synonym: "B-1 B lymphocyte differentiation" EXACT [] synonym: "B-1 B-cell differentiation" EXACT [] synonym: "B-1 B-lymphocyte differentiation" EXACT [] is_a: GO:0002335 ! mature B cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000819 ! results in acquisition of features of B-1 B cell relationship: RO:0002315 CL:0000819 ! results in acquisition of features of B-1 B cell [Term] id: GO:0001924 name: regulation of B-1 B cell differentiation namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of B-1 B cell differentiation. B-1 B cells are a distinct subset of B cells characterized as being CD5 positive, found predominantly in the peritoneum, pleural cavities, and spleen, and enriched for self-reactivity." [GOC:add, ISBN:0781735149] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "regulation of B-1 B cell development" RELATED [GOC:add] synonym: "regulation of B-1 B lymphocyte differentiation" EXACT [] synonym: "regulation of B-1 B-cell differentiation" EXACT [] synonym: "regulation of B-1 B-lymphocyte differentiation" EXACT [] is_a: GO:0045577 ! regulation of B cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0001923 ! regulates B-1 B cell differentiation relationship: RO:0002211 GO:0001923 ! regulates B-1 B cell differentiation [Term] id: GO:0001925 name: negative regulation of B-1 B cell differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the rate of B-1 B cell differentiation." [GOC:add, ISBN:0781735149] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "down regulation of B-1 B cell differentiation" EXACT [] synonym: "down-regulation of B-1 B cell differentiation" EXACT [] synonym: "downregulation of B-1 B cell differentiation" EXACT [] synonym: "inhibition of B-1 B cell differentiation" NARROW [] synonym: "negative regulation of B-1 B cell development" RELATED [GOC:add] synonym: "negative regulation of B-1 B lymphocyte differentiation" EXACT [] synonym: "negative regulation of B-1 B-cell differentiation" EXACT [] synonym: "negative regulation of B-1 B-lymphocyte differentiation" EXACT [] is_a: GO:0001924 ! regulation of B-1 B cell differentiation is_a: GO:0045578 ! negative regulation of B cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0001923 ! negatively regulates B-1 B cell differentiation relationship: RO:0002212 GO:0001923 ! negatively regulates B-1 B cell differentiation [Term] id: GO:0001926 name: positive regulation of B-1 B cell differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of B-1 B cell differentiation." [GOC:add, ISBN:0781735149] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "activation of B-1 B cell differentiation" NARROW [] synonym: "positive regulation of B-1 B cell development" RELATED [GOC:add] synonym: "positive regulation of B-1 B lymphocyte differentiation" EXACT [] synonym: "positive regulation of B-1 B-cell differentiation" EXACT [] synonym: "positive regulation of B-1 B-lymphocyte differentiation" EXACT [] synonym: "stimulation of B-1 B cell differentiation" NARROW [] synonym: "up regulation of B-1 B cell differentiation" EXACT [] synonym: "up-regulation of B-1 B cell differentiation" EXACT [] synonym: "upregulation of B-1 B cell differentiation" EXACT [] is_a: GO:0001924 ! regulation of B-1 B cell differentiation is_a: GO:0045579 ! positive regulation of B cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0001923 ! positively regulates B-1 B cell differentiation relationship: RO:0002213 GO:0001923 ! positively regulates B-1 B cell differentiation [Term] id: GO:0001932 name: regulation of protein phosphorylation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of addition of phosphate groups into an amino acid in a protein." [GOC:hjd] subset: gocheck_obsoletion_candidate synonym: "regulation of protein amino acid phosphorylation" EXACT [GOC:bf] is_a: GO:0031399 ! regulation of protein modification process is_a: GO:0042325 ! regulation of phosphorylation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0006468 ! regulates protein phosphorylation relationship: RO:0002211 GO:0006468 ! regulates protein phosphorylation property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/28278" xsd:anyURI [Term] id: GO:0001933 name: negative regulation of protein phosphorylation namespace: biological_process def: "Any process that stops, prevents or reduces the rate of addition of phosphate groups to amino acids within a protein." [GOC:hjd] subset: gocheck_obsoletion_candidate synonym: "down regulation of protein amino acid phosphorylation" EXACT [] synonym: "down-regulation of protein amino acid phosphorylation" EXACT [] synonym: "downregulation of protein amino acid phosphorylation" EXACT [] synonym: "inhibition of protein amino acid phosphorylation" NARROW [] synonym: "negative regulation of protein amino acid phosphorylation" EXACT [GOC:bf] is_a: GO:0001932 ! regulation of protein phosphorylation is_a: GO:0031400 ! negative regulation of protein modification process is_a: GO:0042326 ! negative regulation of phosphorylation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0006468 ! negatively regulates protein phosphorylation relationship: RO:0002212 GO:0006468 ! negatively regulates protein phosphorylation property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/28278" xsd:anyURI [Term] id: GO:0001934 name: positive regulation of protein phosphorylation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to amino acids within a protein." [GOC:hjd] subset: gocheck_obsoletion_candidate synonym: "activation of protein amino acid phosphorylation" NARROW [] synonym: "positive regulation of protein amino acid phosphorylation" EXACT [GOC:bf] synonym: "stimulation of protein amino acid phosphorylation" NARROW [] synonym: "up regulation of protein amino acid phosphorylation" EXACT [] synonym: "up-regulation of protein amino acid phosphorylation" EXACT [] synonym: "upregulation of protein amino acid phosphorylation" EXACT [] is_a: GO:0001932 ! regulation of protein phosphorylation is_a: GO:0031401 ! positive regulation of protein modification process is_a: GO:0042327 ! positive regulation of phosphorylation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0006468 ! positively regulates protein phosphorylation relationship: RO:0002213 GO:0006468 ! positively regulates protein phosphorylation property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/27189" xsd:anyURI property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/28278" xsd:anyURI [Term] id: GO:0001935 name: endothelial cell proliferation namespace: biological_process def: "The multiplication or reproduction of endothelial cells, resulting in the expansion of a cell population. Endothelial cells are thin flattened cells which line the inside surfaces of body cavities, blood vessels, and lymph vessels, making up the endothelium." [GOC:add, ISBN:0781735149] is_a: GO:0050673 ! epithelial cell proliferation intersection_of: GO:0008283 ! cell population proliferation intersection_of: RO:0012003 CL:0000115 ! acts on population of endothelial cell relationship: RO:0012003 CL:0000115 ! acts on population of endothelial cell property_value: RO:0002161 NCBITaxon:4751 [Term] id: GO:0001936 name: regulation of endothelial cell proliferation namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of endothelial cell proliferation." [GOC:add] is_a: GO:0050678 ! regulation of epithelial cell proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0001935 ! regulates endothelial cell proliferation relationship: RO:0002211 GO:0001935 ! regulates endothelial cell proliferation property_value: RO:0002161 NCBITaxon:4751 [Term] id: GO:0001937 name: negative regulation of endothelial cell proliferation namespace: biological_process def: "Any process that stops, prevents, or reduces the rate or extent of endothelial cell proliferation." [GOC:add] synonym: "down regulation of endothelial cell proliferation" EXACT [] synonym: "down-regulation of endothelial cell proliferation" EXACT [] synonym: "downregulation of endothelial cell proliferation" EXACT [] synonym: "inhibition of endothelial cell proliferation" NARROW [] is_a: GO:0001936 ! regulation of endothelial cell proliferation is_a: GO:0050680 ! negative regulation of epithelial cell proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0001935 ! negatively regulates endothelial cell proliferation relationship: RO:0002212 GO:0001935 ! negatively regulates endothelial cell proliferation property_value: RO:0002161 NCBITaxon:4751 [Term] id: GO:0001938 name: positive regulation of endothelial cell proliferation namespace: biological_process def: "Any process that activates or increases the rate or extent of endothelial cell proliferation." [GOC:add] synonym: "activation of endothelial cell proliferation" NARROW [] synonym: "stimulation of endothelial cell proliferation" NARROW [] synonym: "up regulation of endothelial cell proliferation" EXACT [] synonym: "up-regulation of endothelial cell proliferation" EXACT [] synonym: "upregulation of endothelial cell proliferation" EXACT [] is_a: GO:0001936 ! regulation of endothelial cell proliferation is_a: GO:0050679 ! positive regulation of epithelial cell proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0001935 ! positively regulates endothelial cell proliferation relationship: RO:0002213 GO:0001935 ! positively regulates endothelial cell proliferation property_value: RO:0002161 NCBITaxon:4751 [Term] id: GO:0001940 name: male pronucleus namespace: cellular_component def: "The pronucleus originating from the spermatozoa that was involved in fertilization." [GOC:hjd, ISBN:0198506732] is_a: GO:0045120 ! pronucleus [Term] id: GO:0001941 name: postsynaptic membrane organization namespace: biological_process def: "A process which results in the assembly, arrangement of constituent parts, or disassembly of a postsynaptic membrane, the specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft)." [GOC:dph, GOC:pr] synonym: "post-synaptic membrane organization" EXACT [] synonym: "postsynaptic membrane organisation" EXACT [] is_a: GO:0061024 ! membrane organization intersection_of: GO:0016043 ! cellular component organization intersection_of: RO:0002592 GO:0045211 ! results in organization of postsynaptic membrane relationship: BFO:0000050 GO:0099173 ! part of postsynapse organization relationship: RO:0002592 GO:0045211 ! results in organization of postsynaptic membrane [Term] id: GO:0001942 name: hair follicle development namespace: biological_process def: "The process whose specific outcome is the progression of the hair follicle over time, from its formation to the mature structure. A hair follicle is a tube-like opening in the epidermis where the hair shaft develops and into which the sebaceous glands open." [GOC:dph, UBERON:0002073] is_a: GO:0022405 ! hair cycle process is_a: GO:0048856 ! anatomical structure development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0002073 ! results in development of hair follicle relationship: BFO:0000050 GO:0098773 ! part of skin epidermis development relationship: RO:0002296 UBERON:0002073 ! results in development of hair follicle [Term] id: GO:0001944 name: vasculature development namespace: biological_process def: "The process whose specific outcome is the progression of the vasculature over time, from its formation to the mature structure. The vasculature is an interconnected tubular multi-tissue structure that contains fluid that is actively transported around the organism." [GOC:dph, UBERON:0002409] synonym: "vascular system development" RELATED [] is_a: GO:0048731 ! system development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0002049 ! results in development of vasculature relationship: BFO:0000050 GO:0072359 ! part of circulatory system development relationship: RO:0002296 UBERON:0002049 ! results in development of vasculature [Term] id: GO:0001945 name: lymph vessel development namespace: biological_process def: "The process whose specific outcome is the progression of a lymph vessel over time, from its formation to the mature structure." [GOC:dph, UBERON:0001473] is_a: GO:0048856 ! anatomical structure development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0001473 ! results in development of lymphatic vessel relationship: BFO:0000050 GO:0001944 ! part of vasculature development relationship: RO:0002296 UBERON:0001473 ! results in development of lymphatic vessel [Term] id: GO:0001946 name: lymphangiogenesis namespace: biological_process def: "Lymph vessel formation when new vessels emerge from the proliferation of pre-existing vessels." [GOC:dph, PMID:11596157] synonym: "lymph vessel formation" EXACT systematic_synonym [] xref: Wikipedia:Lymphangiogenesis is_a: BFO:0000003 is_a: GO:0009653 ! anatomical structure morphogenesis is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0001473 ! results in formation of anatomical entity lymphatic vessel relationship: BFO:0000050 GO:0036303 ! part of lymph vessel morphogenesis relationship: RO:0002297 UBERON:0001473 ! results in formation of anatomical entity lymphatic vessel [Term] id: GO:0001949 name: sebaceous gland cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized epidermal cell acquires the specialized features of a sebaceous gland cell." [GOC:mgi_curators, PMID:15737203] synonym: "sebocytes differentiation" NARROW [GOC:mgi_curators] is_a: GO:0009913 ! epidermal cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:2000021 ! results in acquisition of features of sebaceous gland cell relationship: BFO:0000050 GO:0048733 ! part of sebaceous gland development relationship: RO:0002315 CL:2000021 ! results in acquisition of features of sebaceous gland cell [Term] id: GO:0001955 name: blood vessel maturation namespace: biological_process def: "A developmental process, independent of morphogenetic (shape) change, that is required for a blood vessel to attain its fully functional state." [GOC:dph] is_a: GO:0071695 ! anatomical structure maturation intersection_of: GO:0021700 ! developmental maturation intersection_of: RO:0002299 UBERON:0001981 ! results in maturation of blood vessel relationship: BFO:0000050 GO:0001568 ! part of blood vessel development relationship: RO:0002299 UBERON:0001981 ! results in maturation of blood vessel [Term] id: GO:0001956 name: positive regulation of neurotransmitter secretion namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the regulated release of a neurotransmitter." [GOC:hjd] synonym: "activation of neurotransmitter secretion" NARROW [] synonym: "stimulation of neurotransmitter secretion" NARROW [] synonym: "up regulation of neurotransmitter secretion" EXACT [] synonym: "up-regulation of neurotransmitter secretion" EXACT [] synonym: "upregulation of neurotransmitter secretion" EXACT [] is_a: GO:0046928 ! regulation of neurotransmitter secretion is_a: GO:0050806 ! positive regulation of synaptic transmission is_a: GO:0051590 ! positive regulation of neurotransmitter transport is_a: GO:1903532 ! positive regulation of secretion by cell intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0007269 ! positively regulates neurotransmitter secretion relationship: RO:0002213 GO:0007269 ! positively regulates neurotransmitter secretion [Term] id: GO:0001957 name: intramembranous ossification namespace: biological_process def: "Direct ossification that occurs within mesenchyme or an accumulation of relatively unspecialized cells." [ISBN:0878932437] comment: An instance of intramembranous ossification may also be classified as metaplastic; the former classifies based on tissue type location, and the latter based on mechanism/cell division. synonym: "dermal ossification" NARROW [GO_REF:0000034] synonym: "intramembranous bone ossification" RELATED [GOC:cjm] xref: Wikipedia:Intramembranous_ossification is_a: GO:0036072 ! direct ossification [Term] id: GO:0001958 name: endochondral ossification namespace: biological_process def: "Replacement ossification wherein bone tissue replaces cartilage." [GO_REF:0000034, ISBN:0878932437] xref: Wikipedia:Endochondral_ossification is_a: GO:0036075 ! replacement ossification relationship: BFO:0000050 GO:0060350 ! part of endochondral bone morphogenesis [Term] id: GO:0001959 name: regulation of cytokine-mediated signaling pathway namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the cytokine mediated signaling pathway." [GOC:hjd] synonym: "regulation of cytokine and chemokine mediated signaling pathway" EXACT [] synonym: "regulation of cytokine mediated signaling pathway" EXACT [GOC:dph, GOC:tb] synonym: "regulation of cytokine mediated signalling pathway" EXACT [] xref: Reactome:R-HSA-8939247 "RUNX1 regulates transcription of genes involved in interleukin signaling" is_a: GO:0009966 ! regulation of signal transduction is_a: GO:0060759 ! regulation of response to cytokine stimulus intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0019221 ! regulates cytokine-mediated signaling pathway relationship: RO:0002211 GO:0019221 ! regulates cytokine-mediated signaling pathway [Term] id: GO:0001960 name: negative regulation of cytokine-mediated signaling pathway namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the cytokine mediated signaling pathway." [GOC:hjd] synonym: "down regulation of cytokine mediated signaling pathway" EXACT [] synonym: "down-regulation of cytokine mediated signaling pathway" EXACT [] synonym: "downregulation of cytokine mediated signaling pathway" EXACT [] synonym: "inhibition of cytokine mediated signaling pathway" NARROW [] synonym: "negative regulation of cytokine and chemokine mediated signaling pathway" EXACT [] synonym: "negative regulation of cytokine mediated signaling pathway" EXACT [GOC:dph, GOC:tb] synonym: "negative regulation of cytokine mediated signalling pathway" EXACT [] is_a: GO:0001959 ! regulation of cytokine-mediated signaling pathway is_a: GO:0009968 ! negative regulation of signal transduction is_a: GO:0060761 ! negative regulation of response to cytokine stimulus intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0019221 ! negatively regulates cytokine-mediated signaling pathway relationship: RO:0002212 GO:0019221 ! negatively regulates cytokine-mediated signaling pathway [Term] id: GO:0001961 name: positive regulation of cytokine-mediated signaling pathway namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of a cytokine mediated signaling pathway." [GOC:hjd] synonym: "activation of cytokine mediated signaling pathway" NARROW [] synonym: "positive regulation of cytokine and chemokine mediated signaling pathway" EXACT [] synonym: "positive regulation of cytokine mediated signaling pathway" EXACT [GOC:dph, GOC:tb] synonym: "positive regulation of cytokine mediated signalling pathway" EXACT [] synonym: "stimulation of cytokine mediated signaling pathway" NARROW [] synonym: "up regulation of cytokine mediated signaling pathway" EXACT [] synonym: "up-regulation of cytokine mediated signaling pathway" EXACT [] synonym: "upregulation of cytokine mediated signaling pathway" EXACT [] is_a: GO:0001959 ! regulation of cytokine-mediated signaling pathway is_a: GO:0009967 ! positive regulation of signal transduction is_a: GO:0060760 ! positive regulation of response to cytokine stimulus intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0019221 ! positively regulates cytokine-mediated signaling pathway relationship: RO:0002213 GO:0019221 ! positively regulates cytokine-mediated signaling pathway [Term] id: GO:0001963 name: synaptic transmission, dopaminergic namespace: biological_process def: "The vesicular release of dopamine. from a presynapse, across a chemical synapse, the subsequent activation of dopamine receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse." [GOC:dos, GOC:dph] synonym: "dopaminergic synaptic transmission" EXACT [] is_a: GO:0007268 ! chemical synaptic transmission relationship: has_participant CHEBI:59905 relationship: has_participant CL:0000700 ! dopaminergic neuron [Term] id: GO:0001974 name: blood vessel remodeling namespace: biological_process def: "The reorganization or renovation of existing blood vessels." [GOC:hjd] synonym: "blood vessel remodelling" EXACT [] is_a: GO:0048771 ! tissue remodeling property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0001976 name: nervous system process involved in regulation of systemic arterial blood pressure namespace: biological_process def: "The regulation of blood pressure mediated by detection of stimuli and a neurological response." [GOC:mtg_cardio, ISBN:0721643949] synonym: "blood pressure regulation by neurological process" EXACT [] synonym: "fast control of arterial pressure" RELATED [] synonym: "neurological process involved in regulation of systemic arterial blood pressure" EXACT [GOC:dph, GOC:tb] synonym: "neurological system process involved in regulation of systemic arterial blood pressure" EXACT [] is_a: GO:0050877 ! nervous system process intersection_of: GO:0050877 ! nervous system process intersection_of: BFO:0000050 GO:0003073 ! part of regulation of systemic arterial blood pressure relationship: BFO:0000050 GO:0003073 ! part of regulation of systemic arterial blood pressure [Term] id: GO:0001977 name: renal system process involved in regulation of blood volume namespace: biological_process def: "A slow mechanism of blood pressure regulation that responds to changes in pressure resulting from fluid and salt intake by modulating the quantity of blood in the circulatory system." [GOC:dph, GOC:tb, ISBN:0721643949] subset: gocheck_obsoletion_candidate synonym: "renal blood volume control of blood pressure" RELATED [] synonym: "renal regulation of blood volume" RELATED [GOC:dph, GOC:tb] is_a: GO:0003071 ! renal system process involved in regulation of systemic arterial blood pressure relationship: BFO:0000050 GO:0050878 ! part of regulation of body fluid levels property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0001990 name: regulation of systemic arterial blood pressure by hormone namespace: biological_process def: "The process in which hormones modulate the force with which blood passes through the circulatory system. A hormone is one of a group of substances formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells, in the same organism, upon which they have a specific regulatory action." [GOC:mtg_cardio, ISBN:0721643949] synonym: "blood pressure regulation by hormone" EXACT [] synonym: "hormonal control of blood pressure" RELATED [] synonym: "hormonal regulation of blood pressure" EXACT [] is_a: GO:0003044 ! regulation of systemic arterial blood pressure mediated by a chemical signal is_a: GO:0050886 ! endocrine process property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0001991 name: regulation of systemic arterial blood pressure by circulatory renin-angiotensin namespace: biological_process def: "The process in which angiotensinogen metabolites in the bloodstream modulate the force with which blood passes through the circulatory system. The process begins when renin is released and cleaves angiotensinogen." [ISBN:0721643949] synonym: "circulatory renin-angiotensin blood pressure regulation" EXACT [] synonym: "circulatory renin-angiotensin control of blood pressure" RELATED [] synonym: "circulatory renin-angiotensin regulation of blood pressure" EXACT [] synonym: "control of blood pressure by circulatory renin-angiotensin" RELATED [] synonym: "renin-angiotensin blood pressure control" RELATED [] is_a: GO:0003081 ! regulation of systemic arterial blood pressure by renin-angiotensin property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0001992 name: regulation of systemic arterial blood pressure by vasopressin namespace: biological_process def: "The regulation of blood pressure mediated by the signaling molecule vasopressin. Vasopressin is produced in the hypothalamus, and affects vasoconstriction, and renal water transport." [GOC:mtg_cardio, ISBN:0721643949] synonym: "blood pressure regulation by vasopressin" EXACT [] synonym: "vasopressin control of blood pressure" RELATED [] is_a: GO:0001990 ! regulation of systemic arterial blood pressure by hormone property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0001999 name: renal response to blood flow involved in circulatory renin-angiotensin regulation of systemic arterial blood pressure namespace: biological_process def: "The physiological response of the kidneys to a decrease in blood flow." [GOC:dph] synonym: "renal response to blood flow during renin-angiotensin control of blood pressure" RELATED [] is_a: GO:0003071 ! renal system process involved in regulation of systemic arterial blood pressure relationship: BFO:0000050 GO:0001991 ! part of regulation of systemic arterial blood pressure by circulatory renin-angiotensin property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0002001 name: renin secretion into blood stream namespace: biological_process def: "The regulated release of renin into the blood stream by juxtoglomerular cells." [ISBN:0721643949] synonym: "renin release into blood stream" EXACT [] is_a: GO:0009306 ! protein secretion is_a: GO:0023061 ! signal release intersection_of: GO:0046903 ! secretion intersection_of: RO:0004009 PR:000013883 ! has primary input renin relationship: BFO:0000050 GO:0001999 ! part of renal response to blood flow involved in circulatory renin-angiotensin regulation of systemic arterial blood pressure relationship: RO:0004009 PR:000013883 ! has primary input renin property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0002009 name: morphogenesis of an epithelium namespace: biological_process def: "The process in which the anatomical structures of epithelia are generated and organized. An epithelium consists of closely packed cells arranged in one or more layers, that covers the outer surfaces of the body or lines any internal cavity or tube." [GOC:dph, GOC:jl, GOC:tb, ISBN:0198506732] synonym: "epithelium morphogenesis" EXACT [] is_a: GO:0048729 ! tissue morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0000483 ! results in morphogenesis of epithelium relationship: BFO:0000050 GO:0060429 ! part of epithelium development relationship: RO:0002298 UBERON:0000483 ! results in morphogenesis of epithelium [Term] id: GO:0002011 name: morphogenesis of an epithelial sheet namespace: biological_process def: "The process in which the anatomical structures of an epithelial sheet are generated and organized. An epithelial sheet is a flat surface consisting of closely packed epithelial cells." [GOC:jl] is_a: GO:0002009 ! morphogenesis of an epithelium intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0010136 ! results in morphogenesis of epithelial sheet relationship: RO:0002298 UBERON:0010136 ! results in morphogenesis of epithelial sheet [Term] id: GO:0002027 name: regulation of heart rate namespace: biological_process def: "Any process that modulates the frequency or rate of heart contraction." [GOC:dph, GOC:tb, PMID:10358008] synonym: "cardiac chronotropy" EXACT [GOC:dph, GOC:tb] synonym: "regulation of heart contraction rate" EXACT [] synonym: "regulation of rate of heart contraction" EXACT [] is_a: GO:0008016 ! regulation of heart contraction is_a: GO:0065008 ! regulation of biological quality property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0002028 name: regulation of sodium ion transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:dph] synonym: "regulation of Na+ transport" EXACT [] synonym: "regulation of sodium transport" EXACT [] is_a: GO:0010959 ! regulation of metal ion transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0006814 ! regulates sodium ion transport relationship: RO:0002211 GO:0006814 ! regulates sodium ion transport [Term] id: GO:0002036 name: regulation of L-glutamate import across plasma membrane namespace: biological_process def: "Any process that modulates the frequency, rate or extent of L-glutamate import into a cell." [GOC:TermGenie] synonym: "regulation of L-glutamate import" BROAD [] synonym: "regulation of L-glutamate transport" BROAD [] synonym: "regulation of L-glutamate uptake" EXACT [GOC:TermGenie] is_a: GO:0010958 ! regulation of amino acid import across plasma membrane is_a: GO:0032890 ! regulation of organic acid transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0098712 ! regulates L-glutamate import across plasma membrane relationship: RO:0002211 GO:0098712 ! regulates L-glutamate import across plasma membrane creation_date: 2012-06-13T07:34:08Z [Term] id: GO:0002037 name: negative regulation of L-glutamate import across plasma membrane namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of L-glutamate import into a cell." [GOC:TermGenie] synonym: "down regulation of L-glutamate import" EXACT [GOC:TermGenie] synonym: "down regulation of L-glutamate transport" BROAD [] synonym: "down regulation of L-glutamate uptake" RELATED [GOC:TermGenie] synonym: "down-regulation of L-glutamate import" EXACT [GOC:TermGenie] synonym: "down-regulation of L-glutamate transport" BROAD [] synonym: "down-regulation of L-glutamate uptake" RELATED [GOC:TermGenie] synonym: "downregulation of L-glutamate import" EXACT [GOC:TermGenie] synonym: "downregulation of L-glutamate transport" BROAD [] synonym: "downregulation of L-glutamate uptake" RELATED [GOC:TermGenie] synonym: "inhibition of L-glutamate import" NARROW [GOC:TermGenie] synonym: "inhibition of L-glutamate transport" NARROW [] synonym: "inhibition of L-glutamate uptake" NARROW [GOC:TermGenie] synonym: "negative regulation of L-glutamate import" BROAD [] synonym: "negative regulation of L-glutamate transport" BROAD [] synonym: "negative regulation of L-glutamate uptake" RELATED [GOC:TermGenie] synonym: "regulation of L-glutamate import" BROAD [] is_a: GO:0002036 ! regulation of L-glutamate import across plasma membrane is_a: GO:0032891 ! negative regulation of organic acid transport is_a: GO:0034763 ! negative regulation of transmembrane transport is_a: GO:0051956 ! negative regulation of amino acid transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0098712 ! negatively regulates L-glutamate import across plasma membrane relationship: RO:0002212 GO:0098712 ! negatively regulates L-glutamate import across plasma membrane creation_date: 2012-06-13T07:34:30Z [Term] id: GO:0002038 name: positive regulation of L-glutamate import across plasma membrane namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of L-glutamate import into a cell." [GOC:TermGenie] synonym: "activation of L-glutamate import" NARROW [GOC:TermGenie] synonym: "activation of L-glutamate transport" NARROW [] synonym: "activation of L-glutamate uptake" NARROW [GOC:TermGenie] synonym: "positive regulation of L-glutamate import" BROAD [] synonym: "positive regulation of L-glutamate transport" BROAD [] synonym: "positive regulation of L-glutamate uptake" RELATED [GOC:TermGenie] synonym: "stimulation of L-glutamate transport" NARROW [] synonym: "up regulation of L-glutamate import" EXACT [GOC:TermGenie] synonym: "up regulation of L-glutamate transport" BROAD [] synonym: "up regulation of L-glutamate uptake" RELATED [GOC:TermGenie] synonym: "up-regulation of L-glutamate import" EXACT [GOC:TermGenie] synonym: "up-regulation of L-glutamate transport" EXACT [] synonym: "up-regulation of L-glutamate uptake" RELATED [GOC:TermGenie] synonym: "upregulation of L-glutamate import" EXACT [GOC:TermGenie] synonym: "upregulation of L-glutamate transport" BROAD [] synonym: "upregulation of L-glutamate uptake" RELATED [GOC:TermGenie] is_a: GO:0002036 ! regulation of L-glutamate import across plasma membrane is_a: GO:0032892 ! positive regulation of organic acid transport is_a: GO:0034764 ! positive regulation of transmembrane transport is_a: GO:0051957 ! positive regulation of amino acid transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0098712 ! positively regulates L-glutamate import across plasma membrane relationship: RO:0002213 GO:0098712 ! positively regulates L-glutamate import across plasma membrane creation_date: 2012-06-13T07:34:38Z [Term] id: GO:0002052 name: positive regulation of neuroblast proliferation namespace: biological_process def: "Any process that activates or increases the rate of neuroblast proliferation." [GOC:dph] synonym: "activation of neuroblast proliferation" NARROW [] synonym: "stimulation of neuroblast proliferation" NARROW [] synonym: "up regulation of neuroblast proliferation" EXACT [] synonym: "up-regulation of neuroblast proliferation" EXACT [] synonym: "upregulation of neuroblast proliferation" EXACT [] is_a: GO:0050769 ! positive regulation of neurogenesis is_a: GO:1902692 ! regulation of neuroblast proliferation is_a: GO:2000179 ! positive regulation of neural precursor cell proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0007405 ! positively regulates neuroblast proliferation relationship: RO:0002213 GO:0007405 ! positively regulates neuroblast proliferation [Term] id: GO:0002053 name: positive regulation of mesenchymal cell proliferation namespace: biological_process def: "The process of activating or increasing the rate or extent of mesenchymal cell proliferation. Mesenchymal cells are loosely organized embryonic cells." [GOC:dph] synonym: "activation of mesenchymal cell proliferation" NARROW [] synonym: "stimulation of mesenchymal cell proliferation" NARROW [] synonym: "up regulation of mesenchymal cell proliferation" EXACT [] synonym: "up-regulation of mesenchymal cell proliferation" EXACT [] synonym: "upregulation of mesenchymal cell proliferation" EXACT [] is_a: GO:0008284 ! positive regulation of cell population proliferation is_a: GO:0010464 ! regulation of mesenchymal cell proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0010463 ! positively regulates mesenchymal cell proliferation relationship: RO:0002213 GO:0010463 ! positively regulates mesenchymal cell proliferation property_value: RO:0002161 NCBITaxon:4751 [Term] id: GO:0002062 name: chondrocyte differentiation namespace: biological_process def: "The process in which a chondroblast acquires specialized structural and/or functional features of a chondrocyte. A chondrocyte is a polymorphic cell that forms cartilage." [GOC:dph] is_a: GO:0030154 ! cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000138 ! results in acquisition of features of chondrocyte relationship: BFO:0000050 GO:0051216 ! part of cartilage development relationship: RO:0002315 CL:0000138 ! results in acquisition of features of chondrocyte [Term] id: GO:0002063 name: chondrocyte development namespace: biological_process def: "The process whose specific outcome is the progression of a chondrocyte over time, from its commitment to its mature state. Chondrocyte development does not include the steps involved in committing a chondroblast to a chondrocyte fate." [GOC:dph] is_a: GO:0048468 ! cell development intersection_of: GO:0032502 ! developmental process intersection_of: RO:0002296 CL:0000138 ! results in development of chondrocyte relationship: BFO:0000050 GO:0002062 ! part of chondrocyte differentiation relationship: RO:0002296 CL:0000138 ! results in development of chondrocyte [Term] id: GO:0002064 name: epithelial cell development namespace: biological_process def: "The process whose specific outcome is the progression of an epithelial cell over time, from its formation to the mature structure. An epithelial cell is a cell usually found in a two-dimensional sheet with a free surface." [GOC:dph] is_a: GO:0048468 ! cell development intersection_of: GO:0032502 ! developmental process intersection_of: RO:0002296 CL:0000066 ! results in development of epithelial cell relationship: BFO:0000050 GO:0030855 ! part of epithelial cell differentiation relationship: RO:0002296 CL:0000066 ! results in development of epithelial cell [Term] id: GO:0002065 name: columnar/cuboidal epithelial cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a columnar/cuboidal epithelial cell. A columnar/cuboidal epithelial cell is a cell usually found in a two dimensional sheet with a free surface. Columnar/cuboidal epithelial cells take on the shape of a column or cube." [GOC:dph] is_a: GO:0030855 ! epithelial cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000075 ! results in acquisition of features of columnar/cuboidal epithelial cell relationship: RO:0002315 CL:0000075 ! results in acquisition of features of columnar/cuboidal epithelial cell [Term] id: GO:0002066 name: columnar/cuboidal epithelial cell development namespace: biological_process def: "The process whose specific outcome is the progression of a columnar/cuboidal epithelial cell over time, from its formation to the mature structure. A columnar/cuboidal epithelial cell is a cell usually found in a two dimensional sheet with a free surface. Columnar/cuboidal epithelial cells take on the shape of a column or cube." [GOC:dph] is_a: GO:0002064 ! epithelial cell development intersection_of: GO:0032502 ! developmental process intersection_of: RO:0002296 CL:0000075 ! results in development of columnar/cuboidal epithelial cell relationship: BFO:0000050 GO:0002065 ! part of columnar/cuboidal epithelial cell differentiation relationship: RO:0002296 CL:0000075 ! results in development of columnar/cuboidal epithelial cell [Term] id: GO:0002067 name: glandular epithelial cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a glandular epithelial cell. A glandular epithelial cell is a columnar/cuboidal epithelial cell found in a two dimensional sheet with a free surface exposed to the lumen of a gland." [GOC:dph] is_a: GO:0002065 ! columnar/cuboidal epithelial cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000150 ! results in acquisition of features of glandular secretory epithelial cell relationship: RO:0002315 CL:0000150 ! results in acquisition of features of glandular secretory epithelial cell [Term] id: GO:0002068 name: glandular epithelial cell development namespace: biological_process def: "The process whose specific outcome is the progression of a glandular epithelial cell over time, from its formation to the mature structure. A glandular epithelial cell is a columnar/cuboidal epithelial cell is a cell found in a two dimensional sheet with a free surface exposed to the lumen of a gland." [GOC:dph] is_a: GO:0002066 ! columnar/cuboidal epithelial cell development intersection_of: GO:0032502 ! developmental process intersection_of: RO:0002296 CL:0000150 ! results in development of glandular secretory epithelial cell relationship: BFO:0000050 GO:0002067 ! part of glandular epithelial cell differentiation relationship: RO:0002296 CL:0000150 ! results in development of glandular secretory epithelial cell [Term] id: GO:0002069 name: columnar/cuboidal epithelial cell maturation namespace: biological_process def: "The developmental process, independent of morphogenetic (shape) change, that is required for a columna/cuboidal epithelial cell to attain its fully functional state. A columnar/cuboidal epithelial cell is a cell usually found in a two dimensional sheet with a free surface. Columnar/cuboidal epithelial cells take on the shape of a column or cube." [GOC:dph] is_a: GO:0002070 ! epithelial cell maturation intersection_of: GO:0021700 ! developmental maturation intersection_of: RO:0002299 CL:0000075 ! results in maturation of columnar/cuboidal epithelial cell relationship: BFO:0000050 GO:0002066 ! part of columnar/cuboidal epithelial cell development relationship: RO:0002299 CL:0000075 ! results in maturation of columnar/cuboidal epithelial cell [Term] id: GO:0002070 name: epithelial cell maturation namespace: biological_process def: "The developmental process, independent of morphogenetic (shape) change, that is required for an epithelial cell to attain its fully functional state. An epithelial cell is a cell usually found in a two-dimensional sheet with a free surface." [GOC:dph] is_a: GO:0048469 ! cell maturation intersection_of: GO:0021700 ! developmental maturation intersection_of: RO:0002299 CL:0000066 ! results in maturation of epithelial cell relationship: BFO:0000050 GO:0002064 ! part of epithelial cell development relationship: RO:0002299 CL:0000066 ! results in maturation of epithelial cell [Term] id: GO:0002071 name: glandular epithelial cell maturation namespace: biological_process def: "The developmental process, independent of morphogenetic (shape) change, that is required for a glandular epithelial cell to attain its fully functional state. A glandular epithelial cell is a columnar/cuboidal epithelial cell is a cell found in a two dimensional sheet with a free surface exposed to the lumen of a gland." [GOC:dph] is_a: GO:0002069 ! columnar/cuboidal epithelial cell maturation intersection_of: GO:0021700 ! developmental maturation intersection_of: RO:0002299 CL:0000150 ! results in maturation of glandular secretory epithelial cell relationship: BFO:0000050 GO:0002068 ! part of glandular epithelial cell development relationship: RO:0002299 CL:0000150 ! results in maturation of glandular secretory epithelial cell [Term] id: GO:0002072 name: optic cup morphogenesis involved in camera-type eye development namespace: biological_process def: "The invagination of the optic vesicle to form two-walled indentations, the optic cups, that will go on to form the retina. This process begins with the optic vesicle becoming a two-walled structure and its subsequent shape changes. It does not include the fate commitment of cells to become the pigmented retina and the neural retina. An example of this process is found in Mus musculus." [GOC:dph, GOC:mtg_sensu, GOC:sdb_2009, GOC:tb, ISBN:0878932437] synonym: "optic cup morphogenesis involved in camera-style eye development" EXACT [] is_a: GO:0016331 ! morphogenesis of embryonic epithelium intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0003072 ! results in morphogenesis of optic cup relationship: BFO:0000050 GO:0060900 ! part of embryonic camera-type eye formation relationship: RO:0002298 UBERON:0003072 ! results in morphogenesis of optic cup [Term] id: GO:0002074 name: extraocular skeletal muscle development namespace: biological_process def: "The process whose specific outcome is the progression of the extraocular skeletal muscle over time, from its formation to the mature structure. The extraocular muscle is derived from cranial mesoderm and controls eye movements. The muscle begins its development with the differentiation of the muscle cells and ends with the mature muscle. An example of this process is found in Mus musculus." [GOC:dph, GOC:mtg_muscle, GOC:mtg_sensu, MA:0001271, PMID:16638982] is_a: GO:0007519 ! skeletal muscle tissue development is_a: GO:0060538 ! skeletal muscle organ development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0001601 ! results in development of extra-ocular muscle relationship: BFO:0000050 GO:0043010 ! part of camera-type eye development relationship: RO:0002296 UBERON:0001601 ! results in development of extra-ocular muscle [Term] id: GO:0002076 name: osteoblast development namespace: biological_process def: "The process whose specific outcome is the progression of an osteoblast over time, from its formation to the mature structure. Osteoblast development does not include the steps involved in committing a cranial neural crest cell or an osteoprogenitor cell to an osteoblast fate. An osteoblast is a cell that gives rise to bone." [GOC:dph] is_a: GO:0048468 ! cell development intersection_of: GO:0032502 ! developmental process intersection_of: RO:0002296 CL:0000062 ! results in development of osteoblast relationship: BFO:0000050 GO:0001649 ! part of osteoblast differentiation relationship: RO:0002296 CL:0000062 ! results in development of osteoblast [Term] id: GO:0002080 name: acrosomal membrane namespace: cellular_component def: "The membrane that surrounds the acrosomal lumen. The acrosome is a special type of lysosome in the head of a spermatozoon that contains acid hydrolases and is concerned with the breakdown of the outer membrane of the ovum during fertilization." [GOC:dph] is_a: GO:0030667 ! secretory granule membrane intersection_of: GO:0016020 ! membrane intersection_of: RO:0002007 GO:0001669 ! bounding layer of acrosomal vesicle relationship: RO:0002007 GO:0001669 ! bounding layer of acrosomal vesicle property_value: RO:0002161 NCBITaxon:3176 property_value: RO:0002161 NCBITaxon:3378 property_value: RO:0002161 NCBITaxon:3398 property_value: RO:0002161 NCBITaxon:4751 property_value: RO:0002161 NCBITaxon:5782 [Term] id: GO:0002085 name: inhibition of neuroepithelial cell differentiation namespace: biological_process def: "Any process that prevents the activation of neuroepithelial cell differentiation. Neuroepithelial cell differentiation is the process in which epiblast cells acquire specialized features of neuroepithelial cells." [GOC:dph, PMID:16678814] synonym: "negative regulation of neural plate formation" NARROW [GOC:dph, GOC:tb] synonym: "repression of premature neural plate formation" NARROW [GOC:dph, GOC:tb] is_a: GO:0022603 ! regulation of anatomical structure morphogenesis is_a: GO:0030857 ! negative regulation of epithelial cell differentiation is_a: GO:0045995 ! regulation of embryonic development is_a: GO:0048505 ! regulation of timing of cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0060563 ! negatively regulates neuroepithelial cell differentiation relationship: RO:0002212 GO:0060563 ! negatively regulates neuroepithelial cell differentiation [Term] id: GO:0002087 name: regulation of respiratory gaseous exchange by nervous system process namespace: biological_process def: "A process carried out by the nervous system that is required for the proper control of respiratory gaseous exchange. This process occurs in the respiratory center of the brain in vertebrates." [GOC:dph, GOC:tb, PMID:12458206] synonym: "neurological control of breathing" EXACT [GOC:dph, GOC:tb] synonym: "regulation of respiratory gaseous exchange by neurological system process" EXACT [] is_a: GO:0044065 ! regulation of respiratory system process is_a: GO:0050877 ! nervous system process intersection_of: GO:0050877 ! nervous system process intersection_of: RO:0002211 GO:0007585 ! regulates respiratory gaseous exchange by respiratory system [Term] id: GO:0002088 name: lens development in camera-type eye namespace: biological_process def: "The process whose specific outcome is the progression of the lens over time, from its formation to the mature structure. The lens is a transparent structure in the eye through which light is focused onto the retina. An example of this process is found in Mus musculus." [GOC:dph, ISBN:0582064333] synonym: "lens development" EXACT [] synonym: "lens development in camera-style eye" EXACT [] is_a: GO:0048856 ! anatomical structure development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0000965 ! results in development of lens of camera-type eye relationship: BFO:0000050 GO:0043010 ! part of camera-type eye development relationship: RO:0002296 UBERON:0000965 ! results in development of lens of camera-type eye [Term] id: GO:0002089 name: lens morphogenesis in camera-type eye namespace: biological_process def: "The process in which the anatomical structures of the lens are generated and organized. The lens is a transparent structure in the eye through which light is focused onto the retina. An example of this process is found in Mus musculus." [GOC:dph, GOC:mtg_sensu] synonym: "lens morphogenesis" EXACT [] synonym: "lens morphogenesis in camera-style eye" EXACT [] is_a: BFO:0000003 is_a: GO:0009653 ! anatomical structure morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0000965 ! results in morphogenesis of lens of camera-type eye relationship: BFO:0000050 GO:0002088 ! part of lens development in camera-type eye relationship: BFO:0000050 GO:0048593 ! part of camera-type eye morphogenesis relationship: RO:0002298 UBERON:0000965 ! results in morphogenesis of lens of camera-type eye [Term] id: GO:0002093 name: auditory receptor cell morphogenesis namespace: biological_process def: "Any process that alters the size or shape of an auditory receptor cell." [GOC:dph, GOC:tb] synonym: "hair cell morphogenesis" BROAD [GO:dph] is_a: GO:0048598 ! embryonic morphogenesis is_a: GO:0048667 ! cell morphogenesis involved in neuron differentiation intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 CL:0000202 ! results in morphogenesis of auditory hair cell relationship: BFO:0000050 GO:0042472 ! part of inner ear morphogenesis relationship: BFO:0000050 GO:0060117 ! part of auditory receptor cell development relationship: RO:0002298 CL:0000202 ! results in morphogenesis of auditory hair cell [Term] id: GO:0002158 name: osteoclast proliferation namespace: biological_process def: "The multiplication or reproduction of osteoclasts, resulting in the expansion of an osteoclast cell population. An osteoclast is a specialized phagocytic cell associated with the absorption and removal of the mineralized matrix of bone tissue, which typically differentiates from monocytes." [CL:0000092, GOC:hjd] is_a: GO:0070661 ! leukocyte proliferation intersection_of: GO:0008283 ! cell population proliferation intersection_of: RO:0012003 CL:0000092 ! acts on population of osteoclast relationship: RO:0012003 CL:0000092 ! acts on population of osteoclast creation_date: 2010-02-03T01:50:37Z [Term] id: GO:0002159 name: desmosome assembly namespace: biological_process def: "A cellular process that results in the aggregation, arrangement and bonding together of a set of components to form a desmosome. A desmosome is a patch-like intercellular junction found in vertebrate tissues, consisting of parallel zones of two cell membranes, separated by an space of 25-35 nm, and having dense fibrillar plaques in the subjacent cytoplasm." [GOC:hjd, ISBN:0198506732] comment: Desmosomes link two cells together; hemidesmosomes attach one cell to the extracellular matrix. is_a: GO:0002934 ! desmosome organization is_a: GO:0007043 ! cell-cell junction assembly intersection_of: GO:0022607 ! cellular component assembly intersection_of: RO:0002588 GO:0030057 ! results in assembly of desmosome relationship: RO:0002588 GO:0030057 ! results in assembly of desmosome property_value: RO:0002161 NCBITaxon:4751 creation_date: 2010-02-09T10:46:30Z [Term] id: GO:0002164 name: larval development namespace: biological_process def: "The process whose specific outcome is the progression of the larva over time, from its formation to the mature structure. The larva is the early, immature form of an that at birth or hatching is fundamentally unlike its parent and must metamorphose before assuming the adult characters." [GOC:jid, ISBN:0877795088] is_a: GO:0007275 ! multicellular organism development is_a: GO:0009791 ! post-embryonic development property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0002165 name: instar larval or pupal development namespace: biological_process def: "The process whose specific outcome is the progression of the instar larva or pupa over time, from its formation to the mature structure. An example of this process is found in Drosophila melanogaster." [GOC:jid, GOC:mtg_sensu] is_a: GO:0007275 ! multicellular organism development is_a: GO:0009791 ! post-embryonic development relationship: RO:0002162 NCBITaxon:6656 ! in taxon Arthropoda [Term] id: GO:0002176 name: male germ cell proliferation namespace: biological_process def: "The multiplication or reproduction of male germ cells, resulting in the expansion of a cell population." [GOC:hjd] is_a: GO:0036093 ! germ cell proliferation intersection_of: GO:0008283 ! cell population proliferation intersection_of: RO:0012003 CL:0000015 ! acts on population of male germ cell relationship: RO:0012003 CL:0000015 ! acts on population of male germ cell property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4751 creation_date: 2010-11-18T02:35:14Z [Term] id: GO:0002181 name: cytoplasmic translation namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a protein in the cytoplasm. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein." [GOC:hjd] comment: Note that this term applies to translation performed by cytoplasmic ribosomes, which is distinct from translation performed by organellar ribosomes. For mitochondrial translation, consider GO:0032543 'mitochondrial translation' or its child terms. subset: goslim_generic subset: goslim_pombe subset: goslim_yeast is_a: GO:0006412 ! translation intersection_of: GO:0006412 ! translation intersection_of: RO:0002608 GO:0022626 ! process has causal agent cytosolic ribosome relationship: RO:0002608 GO:0022626 ! process has causal agent cytosolic ribosome creation_date: 2011-06-09T03:11:53Z [Term] id: GO:0002182 name: cytoplasmic translational elongation namespace: biological_process def: "The successive addition of amino acid residues to a nascent polypeptide chain during protein biosynthesis in the cytoplasm." [GOC:hjd] is_a: GO:0006414 ! translational elongation intersection_of: GO:0006414 ! translational elongation intersection_of: BFO:0000050 GO:0002181 ! part of cytoplasmic translation relationship: BFO:0000050 GO:0002181 ! part of cytoplasmic translation creation_date: 2011-06-09T03:14:42Z [Term] id: GO:0002183 name: cytoplasmic translational initiation namespace: biological_process def: "The process preceding formation of the peptide bond between the first two amino acids of a protein in the cytoplasm. This includes the formation of a complex of the ribosome, mRNA or circRNA, and an initiation complex that contains the first aminoacyl-tRNA." [GOC:hjd] is_a: GO:0006413 ! translational initiation intersection_of: GO:0006413 ! translational initiation intersection_of: BFO:0000050 GO:0002181 ! part of cytoplasmic translation relationship: BFO:0000050 GO:0002181 ! part of cytoplasmic translation creation_date: 2011-06-09T03:15:48Z [Term] id: GO:0002184 name: cytoplasmic translational termination namespace: biological_process def: "The process resulting in the release of a polypeptide chain from the ribosome in the cytoplasm, usually in response to a termination codon." [GOC:hjd] is_a: GO:0006415 ! translational termination intersection_of: GO:0006415 ! translational termination intersection_of: BFO:0000066 GO:0005829 ! occurs in cytosol relationship: BFO:0000050 GO:0002181 ! part of cytoplasmic translation relationship: BFO:0000066 GO:0005829 ! occurs in cytosol creation_date: 2011-06-09T03:17:13Z [Term] id: GO:0002200 name: somatic diversification of immune receptors namespace: biological_process def: "The somatic process allowing for the production of immune receptors whose specificity is not encoded in the germline genomic sequences." [GOC:add, ISBN:0781735149, PMID:16102575, PMID:16166509] comment: Note that this process covers somatic recombination, gene conversion, hypermutation, N-region addition, and alternate splicing processes of immune receptor diversification. is_a: GO:0002376 ! immune system process relationship: BFO:0000050 GO:0002520 ! part of immune system development property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4895 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0002204 name: somatic recombination of immunoglobulin genes involved in immune response namespace: biological_process def: "The process in which immunoglobulin genes are formed through recombination of the germline genetic elements, also known as immunoglobulin gene segments, within a single locus following the induction of and contributing to an immune response." [GOC:add, ISBN:0781735149] synonym: "somatic recombination of antibody genes during immune response" RELATED [] synonym: "somatic recombination of immunoglobulin genes during immune response" RELATED [GOC:dph] is_a: GO:0002208 ! somatic diversification of immunoglobulins involved in immune response is_a: GO:0016447 ! somatic recombination of immunoglobulin gene segments [Term] id: GO:0002208 name: somatic diversification of immunoglobulins involved in immune response namespace: biological_process def: "The somatic process that results in the generation of sequence diversity of immunoglobulins after induction, and contributes to an immune response." [GOC:add, ISBN:0781735149, PMID:14991701] synonym: "somatic diversification of antibodies during immune response" RELATED [] synonym: "somatic diversification of immunoglobulins during immune response" RELATED [GOC:dph] is_a: GO:0016445 ! somatic diversification of immunoglobulins relationship: BFO:0000050 GO:0002381 ! part of immunoglobulin production involved in immunoglobulin-mediated immune response [Term] id: GO:0002213 name: defense response to insect namespace: biological_process def: "A response to protect an organism from a directly detected or perceived external threat from an insect or insects to that organism." [GOC:add] synonym: "physiological defense response to insect" EXACT [] is_a: BFO:0000003 is_a: GO:0006952 ! defense response is_a: GO:0051707 ! response to other organism intersection_of: GO:0006952 ! defense response intersection_of: RO:0004009 NCBITaxon:50557 ! has primary input Insecta relationship: RO:0004009 NCBITaxon:50557 ! has primary input Insecta property_value: RO:0002161 NCBITaxon:4895 [Term] id: GO:0002215 name: defense response to nematode namespace: biological_process def: "A response to protect an organism from a directly detected or perceived external threat from a nematode or nematodes, which results in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack." [GOC:add, PMID:11516579, PMID:14506883] synonym: "physiological defense response to nematode" EXACT [] is_a: BFO:0000003 is_a: GO:0006952 ! defense response is_a: GO:0051707 ! response to other organism intersection_of: GO:0006952 ! defense response intersection_of: RO:0004009 NCBITaxon:6231 ! has primary input Nematoda relationship: RO:0004009 NCBITaxon:6231 ! has primary input Nematoda property_value: RO:0002161 NCBITaxon:4895 [Term] id: GO:0002225 name: positive regulation of antimicrobial peptide production namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of antimicrobial peptide production." [GOC:add, PMID:11807545] synonym: "activation of antimicrobial peptide production" NARROW [] synonym: "antimicrobial peptide induction" EXACT [] synonym: "stimulation of antimicrobial peptide production" NARROW [] synonym: "up regulation of antimicrobial peptide production" EXACT [] synonym: "up-regulation of antimicrobial peptide production" EXACT [] synonym: "upregulation of antimicrobial peptide production" EXACT [] is_a: GO:0002702 ! positive regulation of production of molecular mediator of immune response is_a: GO:0002760 ! positive regulation of antimicrobial humoral response is_a: GO:0002784 ! regulation of antimicrobial peptide production intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0002775 ! positively regulates antimicrobial peptide production relationship: RO:0002213 GO:0002775 ! positively regulates antimicrobial peptide production property_value: RO:0002161 NCBITaxon:4895 [Term] id: GO:0002227 name: innate immune response in mucosa namespace: biological_process def: "Any process of the innate immune response that takes place in the mucosal tissues." [GOC:add, PMID:10719665, PMID:15971105] is_a: BFO:0000003 is_a: GO:0002385 ! mucosal immune response is_a: GO:0045087 ! innate immune response intersection_of: GO:0045087 ! innate immune response intersection_of: BFO:0000066 UBERON:0000344 ! occurs in mucosa relationship: BFO:0000066 UBERON:0000344 ! occurs in mucosa relationship: RO:0002162 NCBITaxon:7711 ! in taxon Chordata [Term] id: GO:0002228 name: natural killer cell mediated immunity namespace: biological_process def: "The promotion of an immune response by natural killer cells through direct recognition of target cells or through the release of cytokines." [GO_REF:0000022, GOC:add, ISBN:0781735149] synonym: "NK cell mediated immunity" EXACT [] is_a: GO:0002449 ! lymphocyte mediated immunity is_a: GO:0045087 ! innate immune response intersection_of: GO:0002376 ! immune system process intersection_of: RO:0002608 CL:0000623 ! process has causal agent natural killer cell relationship: RO:0002608 CL:0000623 ! process has causal agent natural killer cell [Term] id: GO:0002232 name: leukocyte chemotaxis involved in inflammatory response namespace: biological_process def: "The movement of an immune cell in response to an external stimulus contributing to an inflammatory response." [GOC:add, ISBN:0781735149] synonym: "immune cell chemotaxis during inflammatory response" RELATED [] synonym: "leucocyte chemotaxis during inflammatory response" RELATED [] synonym: "leukocyte chemotaxis during inflammatory response" RELATED [GOC:dph] is_a: GO:0002523 ! leukocyte migration involved in inflammatory response is_a: GO:0030595 ! leukocyte chemotaxis intersection_of: GO:0030595 ! leukocyte chemotaxis intersection_of: BFO:0000050 GO:0006954 ! part of inflammatory response [Term] id: GO:0002233 name: leukocyte chemotaxis involved in immune response namespace: biological_process def: "The movement of an immune cell in response to an external stimulus a part of an immune response." [GOC:add, ISBN:0781735149] synonym: "immune cell chemotaxis during immune response" EXACT [] synonym: "leucocyte chemotaxis during immune response" EXACT [] is_a: GO:0002522 ! leukocyte migration involved in immune response is_a: GO:0030595 ! leukocyte chemotaxis intersection_of: GO:0030595 ! leukocyte chemotaxis intersection_of: BFO:0000050 GO:0006955 ! part of immune response [Term] id: GO:0002244 name: hematopoietic progenitor cell differentiation namespace: biological_process def: "The process in which precursor cell type acquires the specialized features of a hematopoietic progenitor cell, a class of cell types including myeloid progenitor cells and lymphoid progenitor cells." [GOC:add, GOC:rl, ISBN:0781735149, PMID:16551251] synonym: "haematopoietic progenitor cell differentiation" EXACT [] synonym: "haemopoietic progenitor cell differentiation" EXACT [] synonym: "hemopoietic progenitor cell differentiation" EXACT [] is_a: GO:0030154 ! cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0008001 ! results in acquisition of features of hematopoietic precursor cell relationship: BFO:0000050 GO:0030097 ! part of hemopoiesis relationship: RO:0002315 CL:0008001 ! results in acquisition of features of hematopoietic precursor cell [Term] id: GO:0002246 name: wound healing involved in inflammatory response namespace: biological_process def: "The series of events that restore integrity to damaged tissue that contribute to an inflammatory response." [GOC:jal, ISBN:0721601871] synonym: "healing during inflammatory response" RELATED [GOC:dph] synonym: "inflammatory response wound healing" RELATED [GOC:dph] is_a: GO:0042060 ! wound healing intersection_of: GO:0042060 ! wound healing intersection_of: BFO:0000050 GO:0006954 ! part of inflammatory response relationship: BFO:0000050 GO:0090594 ! part of inflammatory response to wounding [Term] id: GO:0002249 name: lymphocyte anergy namespace: biological_process def: "Any process contributing to lymphocyte anergy, a state of functional inactivation." [GOC:add] is_a: BFO:0000003 is_a: GO:0002507 ! tolerance induction relationship: BFO:0000066 CL:0000542 ! occurs in lymphocyte property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4895 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0002250 name: adaptive immune response namespace: biological_process def: "An immune response mediated by cells expressing specific receptors for antigens produced through a somatic diversification process, and allowing for an enhanced secondary response to subsequent exposures to the same antigen (immunological memory)." [GO_REF:0000022, GOC:add, ISBN:0781735149] synonym: "acquired immune response" EXACT [ISBN:068340007X] synonym: "immune memory response" EXACT [GOC:add] xref: Reactome:R-HSA-1280218 "Adaptive Immune System" xref: Wikipedia:Adaptive_immune_system is_a: GO:0006955 ! immune response relationship: RO:0002162 NCBITaxon:33208 ! in taxon Metazoa [Term] id: GO:0002251 name: organ or tissue specific immune response namespace: biological_process def: "An immune response taking place in an organ or tissues such as the liver, brain, mucosa, or nervous system tissues." [GO_REF:0000022, GOC:jal] synonym: "immune response in organ or tissue" EXACT [] is_a: GO:0006955 ! immune response property_value: RO:0002161 NCBITaxon:4895 [Term] id: GO:0002252 name: immune effector process namespace: biological_process def: "Any process of the immune system that executes a component of an immune response. An effector immune process takes place after its activation." [GO_REF:0000022, GOC:add, ISBN:0781735149] is_a: GO:0002376 ! immune system process property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/18737" xsd:anyURI property_value: RO:0002161 NCBITaxon:4895 [Term] id: GO:0002260 name: lymphocyte homeostasis namespace: biological_process def: "The process of regulating the proliferation and elimination of lymphocytes such that the total number of lymphocytes within a whole or part of an organism is stable over time in the absence of an outside stimulus." [GOC:add, PMID:15826826, PMID:16319493, PMID:16551252, PMID:16551262] is_a: GO:0001776 ! leukocyte homeostasis intersection_of: GO:0048872 ! homeostasis of number of cells intersection_of: RO:0012003 CL:0000542 ! acts on population of lymphocyte relationship: RO:0012003 CL:0000542 ! acts on population of lymphocyte [Term] id: GO:0002262 name: myeloid cell homeostasis namespace: biological_process def: "The process of regulating the proliferation and elimination of myeloid cells such that the total number of myeloid cells within a whole or part of an organism is stable over time in the absence of an outside stimulus." [CL:0000763, GOC:add] is_a: BFO:0000003 is_a: GO:0002376 ! immune system process is_a: GO:0048872 ! homeostasis of number of cells intersection_of: GO:0048872 ! homeostasis of number of cells intersection_of: RO:0012003 CL:0000763 ! acts on population of myeloid cell relationship: RO:0012003 CL:0000763 ! acts on population of myeloid cell property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4895 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0002263 name: cell activation involved in immune response namespace: biological_process def: "A change in the morphology or behavior of a cell resulting from exposure to an activating factor such as a cellular or soluble ligand, leading to the initiation or perpetuation of an immune response." [GO_REF:0000022, GOC:add, ISBN:0781735149] synonym: "cell activation during immune response" RELATED [GOC:tb] is_a: GO:0001775 ! cell activation is_a: GO:0002252 ! immune effector process intersection_of: GO:0001775 ! cell activation intersection_of: BFO:0000050 GO:0006955 ! part of immune response relationship: BFO:0000050 GO:0006955 ! part of immune response [Term] id: GO:0002264 name: endothelial cell activation involved in immune response namespace: biological_process def: "A change in the morphology or behavior of an endothelial cell resulting from exposure to an activating factor such as a cellular or soluble ligand, leading to the initiation or perpetuation of an immune response." [GOC:add, ISBN:0781735149] synonym: "endothelial cell activation during immune response" RELATED [GOC:tb] is_a: GO:0002263 ! cell activation involved in immune response is_a: GO:0042118 ! endothelial cell activation intersection_of: GO:0042118 ! endothelial cell activation intersection_of: BFO:0000050 GO:0006955 ! part of immune response [Term] id: GO:0002265 name: astrocyte activation involved in immune response namespace: biological_process def: "A change in the morphology or behavior of an astrocyte resulting from exposure to an activating factor such as a cellular or soluble ligand, leading to the initiation or perpetuation of an immune response." [GOC:add, PMID:11138785] synonym: "astrocyte activation during immune response" RELATED [GOC:tb] is_a: GO:0002263 ! cell activation involved in immune response is_a: GO:0048143 ! astrocyte activation intersection_of: GO:0048143 ! astrocyte activation intersection_of: BFO:0000050 GO:0006955 ! part of immune response [Term] id: GO:0002266 name: follicular dendritic cell activation namespace: biological_process def: "A change in the morphology or behavior of a follicular dendritic cell resulting from exposure to an activating factor such as a cellular or soluble ligand." [GOC:add, PMID:15606789] is_a: GO:0045321 ! leukocyte activation intersection_of: GO:0001775 ! cell activation intersection_of: RO:0004009 CL:0000442 ! has primary input follicular dendritic cell relationship: RO:0004009 CL:0000442 ! has primary input follicular dendritic cell [Term] id: GO:0002267 name: follicular dendritic cell activation involved in immune response namespace: biological_process def: "A change in the morphology or behavior of a follicular dendritic cell resulting from exposure to an activating factor such as a cellular or soluble ligand, leading to the initiation or perpetuation of an immune response." [GOC:add, PMID:15606789] synonym: "follicular dendritic cell activation during immune response" RELATED [GOC:tb] is_a: GO:0002266 ! follicular dendritic cell activation is_a: GO:0002366 ! leukocyte activation involved in immune response intersection_of: GO:0002266 ! follicular dendritic cell activation intersection_of: BFO:0000050 GO:0006955 ! part of immune response [Term] id: GO:0002268 name: follicular dendritic cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized precursor cell acquires the specialized features of a follicular dendritic cell." [GOC:add, ISBN:0781735149] is_a: GO:0002266 ! follicular dendritic cell activation is_a: GO:0097028 ! dendritic cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000442 ! results in acquisition of features of follicular dendritic cell relationship: RO:0002315 CL:0000442 ! results in acquisition of features of follicular dendritic cell [Term] id: GO:0002269 name: leukocyte activation involved in inflammatory response namespace: biological_process def: "A change in the morphology or behavior of a leukocyte resulting from exposure to an activating factor such as a cellular or soluble ligand, leading to the initiation or perpetuation of an inflammatory response." [GOC:add, ISBN:0781735149] synonym: "immune cell activation during inflammatory response" RELATED [] synonym: "leukocyte activation during inflammatory response" RELATED [GOC:tb] is_a: GO:0045321 ! leukocyte activation intersection_of: GO:0045321 ! leukocyte activation intersection_of: BFO:0000050 GO:0006954 ! part of inflammatory response relationship: BFO:0000050 GO:0006954 ! part of inflammatory response [Term] id: GO:0002270 name: plasmacytoid dendritic cell activation namespace: biological_process def: "A change in the morphology or behavior of a plasmacytoid dendritic cell resulting from exposure to an activating factor such as a cellular or soluble ligand." [GOC:add, PMID:15990333, PMID:16174109] is_a: GO:0045321 ! leukocyte activation intersection_of: GO:0001775 ! cell activation intersection_of: RO:0004009 CL:0000784 ! has primary input plasmacytoid dendritic cell relationship: RO:0004009 CL:0000784 ! has primary input plasmacytoid dendritic cell [Term] id: GO:0002271 name: plasmacytoid dendritic cell activation involved in immune response namespace: biological_process def: "A change in the morphology or behavior of a plasmacytoid dendritic cell resulting from exposure to an activating factor such as a cellular or soluble ligand, leading to the initiation or perpetuation of an immune response." [GOC:add, PMID:15990333, PMID:16174109] synonym: "plasmacytoid dendritic cell activation during immune response" RELATED [GOC:tb] is_a: GO:0002270 ! plasmacytoid dendritic cell activation is_a: GO:0002366 ! leukocyte activation involved in immune response intersection_of: GO:0002270 ! plasmacytoid dendritic cell activation intersection_of: BFO:0000050 GO:0006955 ! part of immune response [Term] id: GO:0002272 name: plasmacytoid dendritic cell differentiation involved in immune response namespace: biological_process def: "The process in which an immature plasmacytoid dendritic cell acquires the specialized features of a mature plasmacytoid dendritic cell contributing to an immune response." [GOC:add, PMID:15990333] synonym: "plasmacytoid dendritic cell differentiation during immune response" RELATED [GOC:dph] is_a: GO:0002271 ! plasmacytoid dendritic cell activation involved in immune response is_a: GO:0002273 ! plasmacytoid dendritic cell differentiation intersection_of: GO:0002273 ! plasmacytoid dendritic cell differentiation intersection_of: BFO:0000050 GO:0006955 ! part of immune response [Term] id: GO:0002273 name: plasmacytoid dendritic cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized hemopoietic precursor cell acquires the specialized features of a plasmacytoid dendritic cell." [GOC:add, PMID:15990333, PMID:16174108] is_a: GO:0002270 ! plasmacytoid dendritic cell activation is_a: GO:0097028 ! dendritic cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000784 ! results in acquisition of features of plasmacytoid dendritic cell relationship: RO:0002315 CL:0000784 ! results in acquisition of features of plasmacytoid dendritic cell [Term] id: GO:0002274 name: myeloid leukocyte activation namespace: biological_process def: "A change in the morphology or behavior of a myeloid leukocyte resulting from exposure to an activating factor such as a cellular or soluble ligand." [GOC:add, ISBN:0781735149] synonym: "myeloid leucocyte activation" EXACT [] is_a: GO:0045321 ! leukocyte activation intersection_of: GO:0001775 ! cell activation intersection_of: RO:0004009 CL:0000766 ! has primary input myeloid leukocyte relationship: RO:0004009 CL:0000766 ! has primary input myeloid leukocyte [Term] id: GO:0002275 name: myeloid cell activation involved in immune response namespace: biological_process def: "A change in the morphology or behavior of a myeloid cell resulting from exposure to an activating factor such as a cellular or soluble ligand, leading to the initiation or perpetuation of an immune response." [GOC:add, ISBN:0781735149] synonym: "myeloid cell activation during immune response" RELATED [GOC:tb] is_a: GO:0002274 ! myeloid leukocyte activation is_a: GO:0002366 ! leukocyte activation involved in immune response [Term] id: GO:0002276 name: basophil activation involved in immune response namespace: biological_process def: "A change in morphology and behavior of a basophil resulting from exposure to a cytokine, chemokine, soluble factor, or to (at least in mammals) an antigen which the basophil has specifically bound via IgE bound to Fc-epsilonRI receptors, leading to the initiation or perpetuation of an immune response." [GOC:add, ISBN:0781735149] synonym: "basophil activation during immune response" RELATED [GOC:tb] is_a: GO:0002366 ! leukocyte activation involved in immune response is_a: GO:0045575 ! basophil activation intersection_of: GO:0045575 ! basophil activation intersection_of: BFO:0000050 GO:0006955 ! part of immune response relationship: BFO:0000050 GO:0002275 ! part of myeloid cell activation involved in immune response [Term] id: GO:0002277 name: myeloid dendritic cell activation involved in immune response namespace: biological_process def: "The change in morphology and behavior of a myeloid dendritic cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response." [GOC:add, ISBN:0781735149] synonym: "myeloid dendritic cell activation during immune response" RELATED [GOC:tb] is_a: GO:0001773 ! myeloid dendritic cell activation is_a: GO:0002275 ! myeloid cell activation involved in immune response intersection_of: GO:0001773 ! myeloid dendritic cell activation intersection_of: BFO:0000050 GO:0006955 ! part of immune response [Term] id: GO:0002278 name: eosinophil activation involved in immune response namespace: biological_process def: "The change in morphology and behavior of a eosinophil resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response." [GOC:add, ISBN:0781735149] synonym: "eosinophil activation during immune response" RELATED [GOC:tb] is_a: GO:0002275 ! myeloid cell activation involved in immune response is_a: GO:0043307 ! eosinophil activation intersection_of: GO:0043307 ! eosinophil activation intersection_of: BFO:0000050 GO:0006955 ! part of immune response [Term] id: GO:0002279 name: mast cell activation involved in immune response namespace: biological_process def: "The change in morphology and behavior of a mast cell resulting from exposure to a cytokine, chemokine, soluble factor, or to (at least in mammals) an antigen which the mast cell has specifically bound via IgE bound to Fc-epsilonRI receptors, leading to the initiation or perpetuation of an immune response." [GOC:add, ISBN:0781735149] synonym: "mast cell activation during immune response" RELATED [GOC:tb] is_a: GO:0002275 ! myeloid cell activation involved in immune response is_a: GO:0045576 ! mast cell activation intersection_of: GO:0045576 ! mast cell activation intersection_of: BFO:0000050 GO:0006955 ! part of immune response [Term] id: GO:0002280 name: monocyte activation involved in immune response namespace: biological_process def: "The change in morphology and behavior of a monocyte resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response." [GOC:add, ISBN:0781735149, PMID:16551245] synonym: "monocyte activation during immune response" RELATED [GOC:tb] is_a: GO:0002275 ! myeloid cell activation involved in immune response is_a: GO:0042117 ! monocyte activation intersection_of: GO:0042117 ! monocyte activation intersection_of: BFO:0000050 GO:0006955 ! part of immune response [Term] id: GO:0002281 name: macrophage activation involved in immune response namespace: biological_process def: "A change in morphology and behavior of a macrophage resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response." [GOC:add, ISBN:0781735149] synonym: "macrophage activation during immune response" RELATED [GOC:tb] synonym: "macrophage polarization involved in immune response" EXACT [] is_a: GO:0002366 ! leukocyte activation involved in immune response is_a: GO:0042116 ! macrophage activation intersection_of: GO:0042116 ! macrophage activation intersection_of: BFO:0000050 GO:0006955 ! part of immune response relationship: BFO:0000050 GO:0002275 ! part of myeloid cell activation involved in immune response [Term] id: GO:0002282 name: microglial cell activation involved in immune response namespace: biological_process def: "The change in morphology and behavior of a microglial cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response." [GOC:add, ISBN:0781735149] synonym: "microglial cell activation during immune response" RELATED [GOC:tb] is_a: GO:0001774 ! microglial cell activation is_a: GO:0002281 ! macrophage activation involved in immune response intersection_of: GO:0001774 ! microglial cell activation intersection_of: BFO:0000050 GO:0006955 ! part of immune response [Term] id: GO:0002283 name: neutrophil activation involved in immune response namespace: biological_process def: "The change in morphology and behavior of a neutrophil resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response." [GOC:add, ISBN:0781735149] synonym: "neutrophil activation during immune response" RELATED [GOC:tb] is_a: GO:0002275 ! myeloid cell activation involved in immune response is_a: GO:0042119 ! neutrophil activation intersection_of: GO:0042119 ! neutrophil activation intersection_of: BFO:0000050 GO:0006955 ! part of immune response [Term] id: GO:0002284 name: myeloid dendritic cell differentiation involved in immune response namespace: biological_process def: "The process in which an immature myeloid dendritic cell acquires the specialized features of a mature myeloid dendritic cell as part of an immune response." [GOC:add, ISBN:0781735149] synonym: "myeloid dendritic cell differentiation during immune response" RELATED [GOC:tb] is_a: GO:0002277 ! myeloid dendritic cell activation involved in immune response is_a: GO:0043011 ! myeloid dendritic cell differentiation intersection_of: GO:0043011 ! myeloid dendritic cell differentiation intersection_of: BFO:0000050 GO:0006955 ! part of immune response [Term] id: GO:0002285 name: lymphocyte activation involved in immune response namespace: biological_process def: "A change in morphology and behavior of a lymphocyte resulting from exposure to a specific antigen, mitogen, cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response." [GOC:add, ISBN:0781735149] synonym: "lymphocyte activation during immune response" RELATED [GOC:tb] is_a: GO:0002366 ! leukocyte activation involved in immune response is_a: GO:0046649 ! lymphocyte activation intersection_of: GO:0046649 ! lymphocyte activation intersection_of: BFO:0000050 GO:0006955 ! part of immune response [Term] id: GO:0002286 name: T cell activation involved in immune response namespace: biological_process def: "The change in morphology and behavior of a mature or immature T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific, leading to the initiation or perpetuation of an immune response." [GOC:add, ISBN:0781735149] synonym: "T cell activation during immune response" RELATED [GOC:tb] synonym: "T lymphocyte activation during immune response" RELATED [] synonym: "T-cell activation during immune response" RELATED [] synonym: "T-lymphocyte activation during immune response" RELATED [] is_a: GO:0002285 ! lymphocyte activation involved in immune response is_a: GO:0042110 ! T cell activation intersection_of: GO:0042110 ! T cell activation intersection_of: BFO:0000050 GO:0006955 ! part of immune response [Term] id: GO:0002287 name: alpha-beta T cell activation involved in immune response namespace: biological_process def: "The change in morphology and behavior of an alpha-beta T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific, leading to the initiation or perpetuation of an immune response." [GOC:add, ISBN:0781735149] synonym: "alpha-beta T cell activation during immune response" RELATED [GOC:tb] synonym: "alpha-beta T lymphocyte activation during immune response" RELATED [] synonym: "alpha-beta T-cell activation during immune response" RELATED [] synonym: "alpha-beta T-lymphocyte activation during immune response" RELATED [] is_a: GO:0002286 ! T cell activation involved in immune response is_a: GO:0046631 ! alpha-beta T cell activation intersection_of: GO:0046631 ! alpha-beta T cell activation intersection_of: BFO:0000050 GO:0006955 ! part of immune response [Term] id: GO:0002288 name: NK T cell activation involved in immune response namespace: biological_process def: "The change in morphology and behavior of a mature or immature natural killer T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific, leading to the initiation or perpetuation of an immune response." [GOC:add, PMID:15771592] synonym: "natural killer T lymphocyte activation during immune response" RELATED [] synonym: "natural killer T-cell activation during immune response" RELATED [] synonym: "natural killer T-lymphocyte activation during immune response" RELATED [] synonym: "NK T cell activation during immune response" RELATED [GOC:tb] synonym: "NK T lymphocyte activation during immune response" RELATED [] synonym: "NK T-cell activation during immune response" RELATED [] synonym: "NK T-lymphocyte activation during immune response" RELATED [] is_a: GO:0002287 ! alpha-beta T cell activation involved in immune response is_a: GO:0051132 ! NK T cell activation intersection_of: GO:0051132 ! NK T cell activation intersection_of: BFO:0000050 GO:0006955 ! part of immune response [Term] id: GO:0002289 name: NK T cell proliferation involved in immune response namespace: biological_process def: "The expansion of a NK T cell population by cell division as part of an immune response." [GOC:add, PMID:15771592] synonym: "natural killer T lymphocyte proliferation during immune response" RELATED [] synonym: "natural killer T-cell proliferation during immune response" RELATED [] synonym: "natural killer T-lymphocyte proliferation during immune response" RELATED [] synonym: "NK T cell proliferation during immune response" RELATED [GOC:tb] synonym: "NK T lymphocyte proliferation during immune response" RELATED [] synonym: "NK T-cell proliferation during immune response" RELATED [] synonym: "NK T-lymphocyte proliferation during immune response" RELATED [] is_a: GO:0001866 ! NK T cell proliferation is_a: GO:0002288 ! NK T cell activation involved in immune response is_a: GO:0002310 ! alpha-beta T cell proliferation involved in immune response intersection_of: GO:0001866 ! NK T cell proliferation intersection_of: BFO:0000050 GO:0006955 ! part of immune response [Term] id: GO:0002290 name: gamma-delta T cell activation involved in immune response namespace: biological_process def: "The change in morphology and behavior of a gamma-delta T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific, leading to the initiation or perpetuation of an immune response." [GOC:add, PMID:8717523] synonym: "gamma-delta T cell activation during immune response" RELATED [GOC:tb] synonym: "gamma-delta T lymphocyte activation during immune response" RELATED [] synonym: "gamma-delta T-cell activation during immune response" RELATED [] synonym: "gamma-delta T-lymphocyte activation during immune response" RELATED [] is_a: GO:0002286 ! T cell activation involved in immune response is_a: GO:0046629 ! gamma-delta T cell activation intersection_of: GO:0046629 ! gamma-delta T cell activation intersection_of: BFO:0000050 GO:0006955 ! part of immune response [Term] id: GO:0002292 name: T cell differentiation involved in immune response namespace: biological_process def: "The process in which an antigenically naive T cell acquires the specialized features of an effector, regulatory, or memory T cell as part of an immune response. Effector T cells include cells which provide T cell help or exhibit cytotoxicity towards other cells." [GOC:add, ISBN:0781735149] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "T cell development involved in immune response" RELATED [GOC:add] synonym: "T cell differentiation during immune response" RELATED [GOC:tb] synonym: "T lymphocyte differentiation during immune response" RELATED [] synonym: "T-cell differentiation during immune response" RELATED [] synonym: "T-lymphocyte differentiation during immune response" RELATED [] is_a: GO:0002286 ! T cell activation involved in immune response is_a: GO:0030217 ! T cell differentiation intersection_of: GO:0030217 ! T cell differentiation intersection_of: BFO:0000050 GO:0006955 ! part of immune response [Term] id: GO:0002293 name: alpha-beta T cell differentiation involved in immune response namespace: biological_process def: "The process in which an antigenically naive alpha-beta T cell acquires the specialized features of an effector, regulatory, or memory T cell during an immune response. Effector T cells include cells which provide T cell help or exhibit cytotoxicity towards other cells." [GOC:add, ISBN:0781735149] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "alpha-beta T cell development involved in immune response" RELATED [GOC:add] synonym: "alpha-beta T cell differentiation during immune response" RELATED [GOC:tb] synonym: "alpha-beta T lymphocyte differentiation during immune response" RELATED [] synonym: "alpha-beta T-cell differentiation during immune response" RELATED [] synonym: "alpha-beta T-lymphocyte differentiation during immune response" RELATED [] is_a: GO:0002287 ! alpha-beta T cell activation involved in immune response is_a: GO:0002292 ! T cell differentiation involved in immune response is_a: GO:0046632 ! alpha-beta T cell differentiation intersection_of: GO:0046632 ! alpha-beta T cell differentiation intersection_of: BFO:0000050 GO:0006955 ! part of immune response [Term] id: GO:0002294 name: CD4-positive, alpha-beta T cell differentiation involved in immune response namespace: biological_process def: "The process in which an antigenically naive CD4-positive, alpha-beta T cell acquires the specialized features of an effector, regulatory, or memory T cell as part of an immune response. Effector T cells include cells which provide T cell help or exhibit cytotoxicity towards other cells." [GOC:add, ISBN:0781735149] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "CD4-positive, alpha-beta T cell development involved in immune response" RELATED [GOC:add] synonym: "CD4-positive, alpha-beta T cell differentiation during immune response" RELATED [GOC:tb] synonym: "CD4-positive, alpha-beta T lymphocyte differentiation during immune response" RELATED [] synonym: "CD4-positive, alpha-beta T-cell differentiation during immune response" RELATED [] synonym: "CD4-positive, alpha-beta T-lymphocyte differentiation during immune response" RELATED [] is_a: GO:0002293 ! alpha-beta T cell differentiation involved in immune response is_a: GO:0043367 ! CD4-positive, alpha-beta T cell differentiation intersection_of: GO:0043367 ! CD4-positive, alpha-beta T cell differentiation intersection_of: BFO:0000050 GO:0006955 ! part of immune response [Term] id: GO:0002298 name: CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response namespace: biological_process def: "The process in which an antigenically naive CD4-positive, alpha-beta T cell acquires the specialized features of a CD4-positive, CD25-positive, alpha-beta regulatory T cell as part of an immune response." [GOC:add, PMID:12093005] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation during immune response" RELATED [GOC:tb] synonym: "CD4-positive, CD25-positive, alpha-beta regulatory T lymphocyte differentiation during immune response" RELATED [] synonym: "CD4-positive, CD25-positive, alpha-beta regulatory T-cell differentiation during immune response" RELATED [] synonym: "CD4-positive, CD25-positive, alpha-beta regulatory T-lymphocyte differentiation during immune response" RELATED [] synonym: "CD4-positive, CD25-positive, alpha-beta T cell development involved in immune response" RELATED [GOC:add] is_a: GO:0002294 ! CD4-positive, alpha-beta T cell differentiation involved in immune response is_a: GO:0002361 ! CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation intersection_of: GO:0002361 ! CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation intersection_of: BFO:0000050 GO:0006955 ! part of immune response [Term] id: GO:0002299 name: alpha-beta intraepithelial T cell differentiation namespace: biological_process def: "The process in which a precursor cell type acquires the specialized features of an alpha-beta intraepithelial T cell. Intraepithelial T cells are found among epithelial cells in mucosal areas and have distinct phenotypes and developmental pathways." [GOC:add, ISBN:0781735149] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "alpha-beta intraepithelial T cell development" RELATED [GOC:add] synonym: "alpha-beta intraepithelial T lymphocyte differentiation" EXACT [] synonym: "alpha-beta intraepithelial T-cell differentiation" EXACT [] synonym: "alpha-beta intraepithelial T-lymphocyte differentiation" EXACT [] is_a: GO:0046632 ! alpha-beta T cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000797 ! results in acquisition of features of alpha-beta intraepithelial T cell relationship: RO:0002315 CL:0000797 ! results in acquisition of features of alpha-beta intraepithelial T cell [Term] id: GO:0002300 name: CD8-positive, alpha-beta intraepithelial T cell differentiation namespace: biological_process def: "The process in which a precursor cell type acquires the specialized features of a CD8-positive, alpha-beta intraepithelial T cell. Intraepithelial T cells are found among epithelial cells in mucosal areas and have distinct phenotypes and developmental pathways." [GOC:add, ISBN:0781735149] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "CD8-positive, alpha-beta intraepithelial T cell development" RELATED [GOC:add] synonym: "CD8-positive, alpha-beta intraepithelial T lymphocyte differentiation" EXACT [] synonym: "CD8-positive, alpha-beta intraepithelial T-cell differentiation" EXACT [] synonym: "CD8-positive, alpha-beta intraepithelial T-lymphocyte differentiation" EXACT [] is_a: GO:0002299 ! alpha-beta intraepithelial T cell differentiation is_a: GO:0043374 ! CD8-positive, alpha-beta T cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000796 ! results in acquisition of features of CD8-alpha-beta-positive, alpha-beta intraepithelial T cell relationship: RO:0002315 CL:0000796 ! results in acquisition of features of CD8-alpha-beta-positive, alpha-beta intraepithelial T cell [Term] id: GO:0002301 name: CD4-positive, alpha-beta intraepithelial T cell differentiation namespace: biological_process def: "The process in which a precursor cell type acquires the specialized features of a CD4-positive, alpha-beta intraepithelial T cell. Intraepithelial T cells are found among epithelial cells in mucosal areas and have distinct phenotypes and developmental pathways." [GOC:add, ISBN:0781735149] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "CD4-positive, alpha-beta intraepithelial T cell development" RELATED [GOC:add] synonym: "CD4-positive, alpha-beta intraepithelial T lymphocyte differentiation" EXACT [] synonym: "CD4-positive, alpha-beta intraepithelial T-cell differentiation" EXACT [] synonym: "CD4-positive, alpha-beta intraepithelial T-lymphocyte differentiation" EXACT [] is_a: GO:0002299 ! alpha-beta intraepithelial T cell differentiation is_a: GO:0043367 ! CD4-positive, alpha-beta T cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000793 ! results in acquisition of features of CD4-positive, alpha-beta intraepithelial T cell relationship: RO:0002162 NCBITaxon:7776 ! in taxon Gnathostomata relationship: RO:0002315 CL:0000793 ! results in acquisition of features of CD4-positive, alpha-beta intraepithelial T cell [Term] id: GO:0002302 name: CD8-positive, alpha-beta T cell differentiation involved in immune response namespace: biological_process def: "The process in which an antigenically naive CD8-positive, alpha-beta T cell acquires the specialized features of an effector, regulatory, or memory T cell as part of an immune response. Effector T cells include cells which provide T cell help or exhibit cytotoxicity towards other cells." [GOC:add, ISBN:0781735149] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "CD8-positive, alpha-beta intraepithelial T cell development" RELATED [GOC:add] synonym: "CD8-positive, alpha-beta T cell differentiation during immune response" RELATED [GOC:tb] synonym: "CD8-positive, alpha-beta T lymphocyte differentiation during immune response" RELATED [] synonym: "CD8-positive, alpha-beta T-cell differentiation during immune response" RELATED [] synonym: "CD8-positive, alpha-beta T-lymphocyte differentiation during immune response" RELATED [] is_a: GO:0002293 ! alpha-beta T cell differentiation involved in immune response is_a: GO:0043374 ! CD8-positive, alpha-beta T cell differentiation intersection_of: GO:0043374 ! CD8-positive, alpha-beta T cell differentiation intersection_of: BFO:0000050 GO:0006955 ! part of immune response [Term] id: GO:0002303 name: gamma-delta T cell differentiation involved in immune response namespace: biological_process def: "The process in which an antigenically naive gamma-delta T cell acquires the specialized features of an effector, regulatory, or memory T cell and contributes to an immune response. Effector T cells include cells which provide T cell help or exhibit cytotoxicity towards other cells." [GOC:add] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "gamma-delta T cell development involved in immune response" RELATED [GOC:add] synonym: "gamma-delta T cell differentiation during immune response" RELATED [GOC:dph] synonym: "gamma-delta T lymphocyte differentiation during immune response" RELATED [] synonym: "gamma-delta T-cell differentiation during immune response" RELATED [] synonym: "gamma-delta T-lymphocyte differentiation during immune response" RELATED [] is_a: GO:0002290 ! gamma-delta T cell activation involved in immune response is_a: GO:0002292 ! T cell differentiation involved in immune response is_a: GO:0042492 ! gamma-delta T cell differentiation intersection_of: GO:0042492 ! gamma-delta T cell differentiation intersection_of: BFO:0000050 GO:0006955 ! part of immune response [Term] id: GO:0002304 name: gamma-delta intraepithelial T cell differentiation namespace: biological_process def: "The process in which a precursor cell type acquires the specialized features of a gamma-delta intraepithelial T cell. Intraepithelial T cells are found among epithelial cells in mucosal areas and have distinct phenotypes and developmental pathways." [GOC:add, ISBN:0781735149] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "gamma-delta intraepithelial T cell development" RELATED [GOC:add] synonym: "gamma-delta intraepithelial T lymphocyte differentiation" EXACT [] synonym: "gamma-delta intraepithelial T-cell differentiation" EXACT [] synonym: "gamma-delta intraepithelial T-lymphocyte differentiation" EXACT [] is_a: GO:0042492 ! gamma-delta T cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000801 ! results in acquisition of features of gamma-delta intraepithelial T cell relationship: RO:0002162 NCBITaxon:7776 ! in taxon Gnathostomata relationship: RO:0002315 CL:0000801 ! results in acquisition of features of gamma-delta intraepithelial T cell [Term] id: GO:0002305 name: CD8-positive, gamma-delta intraepithelial T cell differentiation namespace: biological_process def: "The process in which a precursor cell type acquires the specialized features of a CD8-positive, gamma-delta intraepithelial T cell. Intraepithelial T cells are found among epithelial cells in mucosal areas and have distinct phenotypes and developmental pathways." [GOC:add, ISBN:0781735149] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "CD8-positive, gamma-delta intraepithelial T cell development" RELATED [GOC:add] synonym: "CD8-positive, gamma-delta intraepithelial T lymphocyte differentiation" EXACT [] synonym: "CD8-positive, gamma-delta intraepithelial T-cell differentiation" EXACT [] synonym: "CD8-positive, gamma-delta intraepithelial T-lymphocyte differentiation" EXACT [] is_a: GO:0002304 ! gamma-delta intraepithelial T cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000802 ! results in acquisition of features of CD8-alpha alpha positive, gamma-delta intraepithelial T cell relationship: RO:0002315 CL:0000802 ! results in acquisition of features of CD8-alpha alpha positive, gamma-delta intraepithelial T cell [Term] id: GO:0002306 name: CD4-positive gamma-delta intraepithelial T cell differentiation namespace: biological_process def: "The process in which a precursor cell type acquires the specialized features of a CD4-positive, gamma-delta intraepithelial T cell. Intraepithelial T cells are found among epithelial cells in mucosal areas and have distinct phenotypes and developmental pathways." [GOC:add, ISBN:0781735149] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "CD4-positive, gamma-delta intraepithelial T cell development" RELATED [GOC:add] synonym: "CD4-positive, gamma-delta intraepithelial T lymphocyte differentiation" EXACT [] synonym: "CD4-positive, gamma-delta intraepithelial T-cell differentiation" EXACT [] synonym: "CD4-positive, gamma-delta intraepithelial T-lymphocyte differentiation" EXACT [] is_a: GO:0002304 ! gamma-delta intraepithelial T cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000803 ! results in acquisition of features of CD4-negative CD8-negative gamma-delta intraepithelial T cell relationship: RO:0002315 CL:0000803 ! results in acquisition of features of CD4-negative CD8-negative gamma-delta intraepithelial T cell [Term] id: GO:0002307 name: CD8-positive, alpha-beta regulatory T cell differentiation namespace: biological_process def: "The process in which a precursor cell type acquires the specialized features of a CD8-positive, alpha-beta regulatory T cell." [GOC:add, ISBN:0781735149] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "CD8-positive, alpha-beta regulatory T cell development" RELATED [GOC:add] synonym: "CD8-positive, alpha-beta regulatory T lymphocyte differentiation" EXACT [] synonym: "CD8-positive, alpha-beta regulatory T-cell differentiation" EXACT [] synonym: "CD8-positive, alpha-beta regulatory T-lymphocyte differentiation" EXACT [] is_a: GO:0043374 ! CD8-positive, alpha-beta T cell differentiation is_a: GO:0045066 ! regulatory T cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000795 ! results in acquisition of features of CD8-positive, alpha-beta regulatory T cell relationship: RO:0002315 CL:0000795 ! results in acquisition of features of CD8-positive, alpha-beta regulatory T cell [Term] id: GO:0002308 name: CD8-positive, alpha-beta cytotoxic T cell differentiation namespace: biological_process def: "The process in which a precursor cell type acquires the specialized features of a CD8-positive, alpha-beta cytotoxic T cell." [GOC:add, ISBN:0781735149] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "CD8-positive, alpha-beta cytotoxic T cell development" RELATED [GOC:add] synonym: "CD8-positive, alpha-beta cytotoxic T lymphocyte differentiation" EXACT [] synonym: "CD8-positive, alpha-beta cytotoxic T-cell differentiation" EXACT [] synonym: "CD8-positive, alpha-beta cytotoxic T-lymphocyte differentiation" EXACT [] is_a: GO:0043374 ! CD8-positive, alpha-beta T cell differentiation is_a: GO:0045065 ! cytotoxic T cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000794 ! results in acquisition of features of CD8-positive, alpha-beta cytotoxic T cell relationship: RO:0002162 NCBITaxon:7776 ! in taxon Gnathostomata relationship: RO:0002315 CL:0000794 ! results in acquisition of features of CD8-positive, alpha-beta cytotoxic T cell [Term] id: GO:0002309 name: T cell proliferation involved in immune response namespace: biological_process def: "The expansion of a T cell population by cell division as part of an immune response." [GOC:add, ISBN:0781735149] synonym: "T cell proliferation during immune response" RELATED [GOC:tb] synonym: "T lymphocyte proliferation during immune response" RELATED [] synonym: "T-cell proliferation during immune response" RELATED [] synonym: "T-lymphocyte proliferation during immune response" RELATED [] is_a: GO:0002286 ! T cell activation involved in immune response is_a: GO:0042098 ! T cell proliferation intersection_of: GO:0042098 ! T cell proliferation intersection_of: BFO:0000050 GO:0006955 ! part of immune response [Term] id: GO:0002310 name: alpha-beta T cell proliferation involved in immune response namespace: biological_process def: "The expansion of an alpha-beta T cell population by cell division as part of an immune response." [GOC:add, ISBN:0781735149] synonym: "alpha-beta T cell proliferation during immune response" RELATED [GOC:tb] synonym: "alpha-beta T lymphocyte proliferation during immune response" RELATED [] synonym: "alpha-beta T-cell proliferation during immune response" RELATED [] synonym: "alpha-beta T-lymphocyte proliferation during immune response" RELATED [] is_a: GO:0002287 ! alpha-beta T cell activation involved in immune response is_a: GO:0002309 ! T cell proliferation involved in immune response is_a: GO:0046633 ! alpha-beta T cell proliferation intersection_of: GO:0046633 ! alpha-beta T cell proliferation intersection_of: BFO:0000050 GO:0006955 ! part of immune response [Term] id: GO:0002311 name: gamma-delta T cell proliferation involved in immune response namespace: biological_process def: "The expansion of a gamma-delta T cell population by cell division as part of an immune response." [GOC:add] synonym: "gamma-delta T cell proliferation during immune response" RELATED [GOC:tb] synonym: "gamma-delta T lymphocyte proliferation during immune response" RELATED [] synonym: "gamma-delta T-cell proliferation during immune response" RELATED [] synonym: "gamma-delta T-lymphocyte proliferation during immune response" RELATED [] is_a: GO:0002290 ! gamma-delta T cell activation involved in immune response is_a: GO:0002309 ! T cell proliferation involved in immune response is_a: GO:0046630 ! gamma-delta T cell proliferation intersection_of: GO:0046630 ! gamma-delta T cell proliferation intersection_of: BFO:0000050 GO:0006955 ! part of immune response [Term] id: GO:0002312 name: B cell activation involved in immune response namespace: biological_process def: "The change in morphology and behavior of a mature or immature B cell during an immune response, resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific." [GOC:jal] synonym: "B cell activation during immune response" RELATED [GOC:tb] synonym: "B lymphocyte activation during immune response" RELATED [] synonym: "B-cell activation during immune response" RELATED [] synonym: "B-lymphocyte activation during immune response" RELATED [] is_a: GO:0002285 ! lymphocyte activation involved in immune response is_a: GO:0042113 ! B cell activation intersection_of: GO:0042113 ! B cell activation intersection_of: BFO:0000050 GO:0006955 ! part of immune response [Term] id: GO:0002313 name: mature B cell differentiation involved in immune response namespace: biological_process def: "The process in which a naive B cell acquires the specialized features of a mature or memory B cell during an immune response." [GOC:jal] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "mature B cell development involved in immune response" RELATED [GOC:add] synonym: "mature B cell differentiation during immune response" RELATED [GOC:tb] synonym: "mature B lymphocyte differentiation during immune response" RELATED [] synonym: "mature B-cell differentiation during immune response" RELATED [] synonym: "mature B-lymphocyte differentiation during immune response" RELATED [] is_a: GO:0002312 ! B cell activation involved in immune response is_a: GO:0002335 ! mature B cell differentiation intersection_of: GO:0002335 ! mature B cell differentiation intersection_of: BFO:0000050 GO:0006955 ! part of immune response [Term] id: GO:0002314 name: germinal center B cell differentiation namespace: biological_process def: "The process in which a B cell in the spleen acquires the specialized features of a germinal center B cell. Germinal center B cells are rapidly cycling B cells which have downregulated IgD expression and exhibit high levels of binding by peanut agglutinin (PNA)." [GOC:jal, ISBN:0781735149] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "germinal center B cell development" RELATED [GOC:add] synonym: "germinal center B lymphocyte differentiation" EXACT [] synonym: "germinal center B-cell differentiation" EXACT [] synonym: "germinal center B-lymphocyte differentiation" EXACT [] is_a: GO:0002313 ! mature B cell differentiation involved in immune response intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000844 ! results in acquisition of features of germinal center B cell relationship: RO:0002315 CL:0000844 ! results in acquisition of features of germinal center B cell [Term] id: GO:0002315 name: marginal zone B cell differentiation namespace: biological_process def: "The process in which a B cell in the spleen acquires the specialized features of a marginal zone B cell. Marginal zone B cells are localized in a distinct anatomical region of the spleen that represents the major antigen-filtering and scavenging area (by specialized macrophages resident there). It appears that they are preselected to express a BCR repertoire similar to B-1 B cells, biased toward bacterial cell wall constituents and senescent self-components (such as oxidized LDL)." [GOC:jal, ISBN:0781735149] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "marginal zone B cell development" RELATED [GOC:add] synonym: "marginal zone B lymphocyte differentiation" EXACT [] synonym: "marginal zone B-cell differentiation" EXACT [] synonym: "marginal zone B-lymphocyte differentiation" EXACT [] is_a: GO:0002313 ! mature B cell differentiation involved in immune response intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000845 ! results in acquisition of features of marginal zone B cell of spleen relationship: RO:0002315 CL:0000845 ! results in acquisition of features of marginal zone B cell of spleen [Term] id: GO:0002316 name: follicular B cell differentiation namespace: biological_process def: "The process in which a B cell in the spleen acquires the specialized features of a follicular B cell. Follicular B cells are major population of mature recirculating B cells in the spleen and are located in the B-cell follicle region." [GOC:jal, ISBN:0781735149] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "follicular B cell development" RELATED [GOC:add] synonym: "follicular B lymphocyte differentiation" EXACT [] synonym: "follicular B-cell differentiation" EXACT [] synonym: "follicular B-lymphocyte differentiation" EXACT [] is_a: GO:0002313 ! mature B cell differentiation involved in immune response intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000843 ! results in acquisition of features of follicular B cell relationship: RO:0002315 CL:0000843 ! results in acquisition of features of follicular B cell [Term] id: GO:0002317 name: plasma cell differentiation namespace: biological_process def: "The process in which a B cell acquires the specialized features of a plasma cell. A plasma cell is a lymphocyte which develops from a B cell and produces high amounts of antibody." [GOC:jal] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "plasma cell development" RELATED [GOC:add] is_a: GO:0002313 ! mature B cell differentiation involved in immune response intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000786 ! results in acquisition of features of plasma cell relationship: RO:0002315 CL:0000786 ! results in acquisition of features of plasma cell [Term] id: GO:0002318 name: myeloid progenitor cell differentiation namespace: biological_process def: "The process in which a precursor cell type acquires the specialized features of a myeloid progenitor cell. Myeloid progenitor cells include progenitor cells for any of the myeloid lineages." [GOC:add, PMID:16551264] is_a: GO:0002244 ! hematopoietic progenitor cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000839 ! results in acquisition of features of myeloid lineage restricted progenitor cell relationship: RO:0002315 CL:0000839 ! results in acquisition of features of myeloid lineage restricted progenitor cell [Term] id: GO:0002319 name: memory B cell differentiation namespace: biological_process def: "The process in which a B cell acquires the specialized features of a memory B cell. Memory B cells are cells that can respond rapidly to antigen re-exposure by production of high-affinity antibody." [GOC:jal, ISBN:0781735149] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "memory B cell development" RELATED [GOC:add] synonym: "memory B lymphocyte differentiation" EXACT [] synonym: "memory B-cell differentiation" EXACT [] synonym: "memory B-lymphocyte differentiation" EXACT [] is_a: GO:0002313 ! mature B cell differentiation involved in immune response is_a: GO:0090715 ! immunological memory formation process intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000787 ! results in acquisition of features of memory B cell relationship: RO:0002315 CL:0000787 ! results in acquisition of features of memory B cell [Term] id: GO:0002320 name: lymphoid progenitor cell differentiation namespace: biological_process def: "The process in which a precursor cell type acquires the specialized features of a lymphoid progenitor cell. Lymphoid progenitor cells include progenitor cells for any of the lymphoid lineages." [GOC:add, PMID:16551251, PMID:16551264] is_a: GO:0002244 ! hematopoietic progenitor cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000838 ! results in acquisition of features of lymphoid lineage restricted progenitor cell relationship: RO:0002315 CL:0000838 ! results in acquisition of features of lymphoid lineage restricted progenitor cell [Term] id: GO:0002321 name: natural killer cell progenitor differentiation namespace: biological_process def: "The process in which a precursor cell type acquires the specialized features of a natural killer cell progenitor." [GOC:add, PMID:16551251, PMID:16551264] is_a: GO:0002320 ! lymphoid progenitor cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000825 ! results in acquisition of features of pro-NK cell relationship: RO:0002315 CL:0000825 ! results in acquisition of features of pro-NK cell [Term] id: GO:0002322 name: B cell proliferation involved in immune response namespace: biological_process def: "The expansion of a B cell population by cell division following B cell activation during an immune response." [GOC:jal] synonym: "B cell proliferation during immune response" RELATED [GOC:tb] synonym: "B lymphocyte proliferation during immune response" RELATED [] synonym: "B-cell proliferation during immune response" RELATED [] synonym: "B-lymphocyte proliferation during immune response" RELATED [] is_a: GO:0002312 ! B cell activation involved in immune response is_a: GO:0042100 ! B cell proliferation intersection_of: GO:0042100 ! B cell proliferation intersection_of: BFO:0000050 GO:0006955 ! part of immune response [Term] id: GO:0002323 name: natural killer cell activation involved in immune response namespace: biological_process def: "The change in morphology and behavior of a natural killer cell resulting from exposure a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response." [GOC:add, PMID:15032583] synonym: "natural killer cell activation during immune response" RELATED [GOC:tb] synonym: "NK cell activation during immune response" RELATED [] is_a: GO:0002285 ! lymphocyte activation involved in immune response is_a: GO:0030101 ! natural killer cell activation intersection_of: GO:0030101 ! natural killer cell activation intersection_of: BFO:0000050 GO:0045087 ! part of innate immune response relationship: BFO:0000050 GO:0045087 ! part of innate immune response [Term] id: GO:0002324 name: natural killer cell proliferation involved in immune response namespace: biological_process def: "The expansion of a natural killer cell population by cell division as part of an immune response." [GOC:add, PMID:15032583] synonym: "natural killer cell proliferation during immune response" RELATED [GOC:tb] synonym: "NK cell proliferation during immune response" RELATED [] is_a: GO:0001787 ! natural killer cell proliferation is_a: GO:0002285 ! lymphocyte activation involved in immune response intersection_of: GO:0001787 ! natural killer cell proliferation intersection_of: BFO:0000050 GO:0006955 ! part of immune response [Term] id: GO:0002325 name: natural killer cell differentiation involved in immune response namespace: biological_process def: "The process in which a naive natural killer cell acquires the specialized features of an effector natural killer T cell as part of an immune response." [GOC:add, PMID:11698225] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "natural killer cell development involved in immune response" RELATED [GOC:add] synonym: "natural killer cell differentiation during immune response" RELATED [GOC:tb] synonym: "NK cell differentiation during immune response" RELATED [] is_a: GO:0001779 ! natural killer cell differentiation is_a: GO:0002285 ! lymphocyte activation involved in immune response intersection_of: GO:0001779 ! natural killer cell differentiation intersection_of: BFO:0000050 GO:0006955 ! part of immune response [Term] id: GO:0002327 name: immature B cell differentiation namespace: biological_process def: "The process in which a precursor cell type acquires the specialized features of an immature B cell." [GOC:jal, ISBN:0781735149, PMID:16551251] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "immature B cell development" RELATED [GOC:add] synonym: "immature B lymphocyte differentiation" EXACT [] synonym: "immature B-cell differentiation" EXACT [] synonym: "immature B-lymphocyte differentiation" EXACT [] is_a: GO:0030183 ! B cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000816 ! results in acquisition of features of immature B cell relationship: RO:0002315 CL:0000816 ! results in acquisition of features of immature B cell [Term] id: GO:0002328 name: pro-B cell differentiation namespace: biological_process def: "The process in which a precursor cell type acquires the specialized features of a pro-B cell. Pro-B cells are the earliest stage of the B cell lineage and undergo heavy chain D and J gene rearrangements, although they are not fully committed." [GOC:jal, ISBN:0781735149] synonym: "pro-B cell development" RELATED [GOC:add] synonym: "pro-B lymphocyte differentiation" EXACT [] is_a: GO:0002320 ! lymphoid progenitor cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000826 ! results in acquisition of features of pro-B cell relationship: RO:0002315 CL:0000826 ! results in acquisition of features of pro-B cell [Term] id: GO:0002329 name: pre-B cell differentiation namespace: biological_process def: "The process in which a precursor cell type acquires the specialized features of a pre-B cell. Pre-B cells follow the pro-B cell stage of immature B cell differentiation and undergo rearrangement of heavy chain V, D, and J gene segments." [GOC:jal, ISBN:0781735149] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "pre-B cell development" RELATED [GOC:add] synonym: "pre-B lymphocyte differentiation" EXACT [] is_a: GO:0002327 ! immature B cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000817 ! results in acquisition of features of precursor B cell relationship: RO:0002315 CL:0000817 ! results in acquisition of features of precursor B cell [Term] id: GO:0002332 name: transitional stage B cell differentiation namespace: biological_process def: "The process in which immature B cells from the bone marrow become mature B cells in the spleen. Transitional stage B cells are subdivided into transitional one (T1) and transitional two (T2) stages and are short-lived and functionally incompetent." [GOC:jal, ISBN:0781735149] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "transitional stage B cell development" RELATED [GOC:add] synonym: "transitional stage B lymphocyte differentiation" EXACT [] synonym: "transitional stage B-cell differentiation" EXACT [] synonym: "transitional stage B-lymphocyte differentiation" EXACT [] is_a: GO:0002327 ! immature B cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000818 ! results in acquisition of features of transitional stage B cell relationship: RO:0002315 CL:0000818 ! results in acquisition of features of transitional stage B cell [Term] id: GO:0002335 name: mature B cell differentiation namespace: biological_process def: "The process in which transitional stage B cells acquire the specialized features of mature B cells in the spleen." [GOC:jal, ISBN:0781735149] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "mature B lymphocyte differentiation" EXACT [] synonym: "mature B-cell differentiation" EXACT [] synonym: "mature B-lymphocyte differentiation" EXACT [] synonym: "mature cell development" RELATED [GOC:add] is_a: GO:0030183 ! B cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000785 ! results in acquisition of features of mature B cell relationship: RO:0002315 CL:0000785 ! results in acquisition of features of mature B cell [Term] id: GO:0002337 name: B-1a B cell differentiation namespace: biological_process def: "The process in which B cells acquire the specialized features of B-1a B cells. B-1a B cells are B-1 cells that express CD5 and arise from fetal liver precursors." [GOC:jal, ISBN:0781735149] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "B-1a B cell development" RELATED [GOC:add] synonym: "B-1a B lymphocyte differentiation" EXACT [] synonym: "B-1a B-cell differentiation" EXACT [] synonym: "B-1a B-lymphocyte differentiation" EXACT [] is_a: GO:0001923 ! B-1 B cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000820 ! results in acquisition of features of B-1a B cell relationship: RO:0002315 CL:0000820 ! results in acquisition of features of B-1a B cell [Term] id: GO:0002338 name: B-1b B cell differentiation namespace: biological_process def: "The process in which B cells acquire the specialized features of B-1b B cells. B-1b B cells are B-1 cells that do not express CD5." [GOC:jal, ISBN:0781735149] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "B-1b B cell development" RELATED [GOC:add] synonym: "B-1b B lymphocyte differentiation" EXACT [] synonym: "B-1b B-cell differentiation" EXACT [] synonym: "B-1b B-lymphocyte differentiation" EXACT [] is_a: GO:0001923 ! B-1 B cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000821 ! results in acquisition of features of B-1b B cell relationship: RO:0002315 CL:0000821 ! results in acquisition of features of B-1b B cell [Term] id: GO:0002339 name: B cell selection namespace: biological_process def: "The process dependent upon B cell antigen receptor signaling in response to self or foreign antigen through which B cells are selected for survival." [GOC:jal] synonym: "B lymphocyte selection" EXACT [] synonym: "B-cell selection" EXACT [] synonym: "B-lymphocyte selection" EXACT [] is_a: BFO:0000003 is_a: GO:0002376 ! immune system process relationship: BFO:0000050 GO:0030183 ! part of B cell differentiation relationship: has_participant CL:0000236 ! B cell [Term] id: GO:0002343 name: peripheral B cell selection namespace: biological_process def: "Any B cell selection process that occurs in the periphery." [GOC:jal] synonym: "peripheral B lymphocyte selection" EXACT [] synonym: "peripheral B-cell selection" EXACT [] synonym: "peripheral B-lymphocyte selection" EXACT [] is_a: GO:0002339 ! B cell selection [Term] id: GO:0002344 name: B cell affinity maturation namespace: biological_process def: "The process in which B cells produce antibodies with increased antigen affinity. This is accomplished by somatic hypermutation and selection for B cells which produce higher affinity antibodies to antigen." [GO_REF:0000022, GOC:jal, ISBN:0781735149] synonym: "B lymphocyte affinity maturation" EXACT [] synonym: "B-cell affinity maturation" EXACT [] synonym: "B-lymphocyte affinity maturation" EXACT [] is_a: GO:0002343 ! peripheral B cell selection relationship: BFO:0000050 GO:0002381 ! part of immunoglobulin production involved in immunoglobulin-mediated immune response [Term] id: GO:0002349 name: histamine production involved in inflammatory response namespace: biological_process def: "The synthesis or release of histamine following a stimulus as part of an inflammatory response, resulting in an increase in its intracellular or extracellular levels." [GOC:add, ISBN:0781735149, PMID:16730260] synonym: "histamine production involved in acute inflammatory response" BROAD [] is_a: GO:0002532 ! production of molecular mediator involved in inflammatory response [Term] id: GO:0002351 name: serotonin production involved in inflammatory response namespace: biological_process def: "The synthesis or release of serotonin following a stimulus as part of an inflammatory response, resulting in an increase in its intracellular or extracellular levels." [GOC:add, ISBN:0781735149, PMID:16730260] synonym: "serotonin production involved in acute inflammatory response" BROAD [] is_a: GO:0002532 ! production of molecular mediator involved in inflammatory response [Term] id: GO:0002358 name: B cell homeostatic proliferation namespace: biological_process def: "The non-specific expansion of B cell populations within a whole or part of an organism to reach to a total number of B cells which will then remain stable over time in the absence of an external stimulus." [GOC:jal] synonym: "B lymphocyte homeostatic proliferation" EXACT [] synonym: "B-cell homeostatic proliferation" EXACT [] synonym: "B-lymphocyte homeostatic proliferation" EXACT [] is_a: GO:0042100 ! B cell proliferation intersection_of: GO:0008283 ! cell population proliferation intersection_of: BFO:0000050 GO:0042592 ! part of homeostatic process intersection_of: RO:0012003 CL:0000236 ! acts on population of B cell relationship: BFO:0000050 GO:0042592 ! part of homeostatic process [Term] id: GO:0002359 name: B-1 B cell proliferation namespace: biological_process def: "The expansion of a B-1 B cell by cell division. Follows B cell activation." [GOC:jal] synonym: "B-1 B lymphocyte proliferation" EXACT [] synonym: "B-1 B-cell proliferation" EXACT [] synonym: "B-1 B-lymphocyte proliferation" EXACT [] is_a: GO:0042100 ! B cell proliferation intersection_of: GO:0008283 ! cell population proliferation intersection_of: RO:0012003 CL:0000819 ! acts on population of B-1 B cell relationship: RO:0012003 CL:0000819 ! acts on population of B-1 B cell [Term] id: GO:0002361 name: CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation namespace: biological_process def: "The process in which a precursor cell type acquires the specialized features of a CD4-positive, CD25-positive, alpha-beta regulatory T cell." [GOC:add, PMID:15207821] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "CD4-positive, CD25-positive, alpha-beta regulatory T cell development" RELATED [GOC:add] synonym: "CD4-positive, CD25-positive, alpha-beta regulatory T lymphocyte differentiation" EXACT [] synonym: "CD4-positive, CD25-positive, alpha-beta regulatory T-cell differentiation" EXACT [] synonym: "CD4-positive, CD25-positive, alpha-beta regulatory T-lymphocyte differentiation" EXACT [] is_a: GO:0043367 ! CD4-positive, alpha-beta T cell differentiation is_a: GO:0045066 ! regulatory T cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000792 ! results in acquisition of features of CD4-positive, CD25-positive, alpha-beta regulatory T cell relationship: RO:0002315 CL:0000792 ! results in acquisition of features of CD4-positive, CD25-positive, alpha-beta regulatory T cell [Term] id: GO:0002366 name: leukocyte activation involved in immune response namespace: biological_process def: "A change in morphology and behavior of a leukocyte resulting from exposure to a specific antigen, mitogen, cytokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response." [GOC:add, ISBN:0781735149] synonym: "immune cell activation during immune response" RELATED [] synonym: "leucocyte activation during immune response" RELATED [] synonym: "leukocyte activation during immune response" RELATED [GOC:tb] is_a: GO:0002263 ! cell activation involved in immune response is_a: GO:0045321 ! leukocyte activation intersection_of: GO:0045321 ! leukocyte activation intersection_of: BFO:0000050 GO:0006955 ! part of immune response [Term] id: GO:0002367 name: cytokine production involved in immune response namespace: biological_process def: "The appearance of a cytokine due to biosynthesis or secretion following a cellular stimulus contributing to an immune response, resulting in an increase in its intracellular or extracellular levels." [GO_REF:0000022, GOC:add, ISBN:0781735149] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms. subset: gocheck_do_not_annotate synonym: "cytokine biosynthetic process involved in immune response" NARROW [] synonym: "cytokine production during immune response" RELATED [GOC:dph] synonym: "cytokine secretion during immune response" RELATED [GOC:dph] synonym: "cytokine secretion involved in immune response" RELATED [] is_a: GO:0001816 ! cytokine production is_a: GO:0002440 ! production of molecular mediator of immune response intersection_of: GO:0001816 ! cytokine production intersection_of: BFO:0000050 GO:0006955 ! part of immune response relationship: BFO:0000050 GO:0006955 ! part of immune response property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4895 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0002368 name: B cell cytokine production namespace: biological_process def: "Any process that contributes to cytokine production by a B cell." [GOC:add, ISBN:0781735149] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms. subset: gocheck_do_not_annotate synonym: "B lymphocyte cytokine production" EXACT [] synonym: "B-cell cytokine production" EXACT [] synonym: "B-lymphocyte cytokine production" EXACT [] is_a: GO:0002367 ! cytokine production involved in immune response is_a: GO:0019724 ! B cell mediated immunity intersection_of: GO:0001816 ! cytokine production intersection_of: RO:0002608 CL:0000236 ! process has causal agent B cell [Term] id: GO:0002369 name: T cell cytokine production namespace: biological_process def: "Any process that contributes to cytokine production by a T cell." [GOC:add, ISBN:0781735149] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms. subset: gocheck_do_not_annotate synonym: "T lymphocyte cytokine production" EXACT [] synonym: "T-cell cytokine production" EXACT [] synonym: "T-lymphocyte cytokine production" EXACT [] is_a: GO:0002367 ! cytokine production involved in immune response is_a: GO:0002456 ! T cell mediated immunity intersection_of: GO:0001816 ! cytokine production intersection_of: RO:0002608 CL:0000084 ! process has causal agent T cell [Term] id: GO:0002370 name: natural killer cell cytokine production namespace: biological_process def: "Any process that contributes to cytokine production by a natural killer cell." [GOC:add, ISBN:0781735149] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms. subset: gocheck_do_not_annotate synonym: "NK cell cytokine production" EXACT [] is_a: GO:0002228 ! natural killer cell mediated immunity is_a: GO:0002367 ! cytokine production involved in immune response intersection_of: GO:0001816 ! cytokine production intersection_of: RO:0002608 CL:0000623 ! process has causal agent natural killer cell [Term] id: GO:0002371 name: dendritic cell cytokine production namespace: biological_process def: "Any process that contributes to cytokine production by a dendritic cell." [GOC:add, ISBN:0781735149] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms. subset: gocheck_do_not_annotate is_a: GO:0002367 ! cytokine production involved in immune response is_a: GO:0002443 ! leukocyte mediated immunity intersection_of: GO:0001816 ! cytokine production intersection_of: RO:0002608 CL:0000451 ! process has causal agent dendritic cell relationship: RO:0002608 CL:0000451 ! process has causal agent dendritic cell [Term] id: GO:0002372 name: myeloid dendritic cell cytokine production namespace: biological_process def: "Any process that contributes to cytokine production by a myeloid dendritic cell." [GOC:add, ISBN:0781735149] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms. subset: gocheck_do_not_annotate is_a: GO:0002371 ! dendritic cell cytokine production is_a: GO:0002444 ! myeloid leukocyte mediated immunity is_a: GO:0061082 ! myeloid leukocyte cytokine production intersection_of: GO:0001816 ! cytokine production intersection_of: RO:0002608 CL:0000782 ! process has causal agent myeloid dendritic cell relationship: RO:0002608 CL:0000782 ! process has causal agent myeloid dendritic cell [Term] id: GO:0002373 name: plasmacytoid dendritic cell cytokine production namespace: biological_process def: "Any process that contributes to cytokine production by a plasmacytoid dendritic cell." [GOC:add, ISBN:0781735149] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms. subset: gocheck_do_not_annotate is_a: GO:0002371 ! dendritic cell cytokine production intersection_of: GO:0001816 ! cytokine production intersection_of: RO:0002608 CL:0000784 ! process has causal agent plasmacytoid dendritic cell relationship: RO:0002608 CL:0000784 ! process has causal agent plasmacytoid dendritic cell [Term] id: GO:0002376 name: immune system process namespace: biological_process def: "Any process involved in the development or functioning of the immune system, an organismal system for calibrated responses to potential internal or invasive threats." [GO_REF:0000022, GOC:add] comment: Note that this term is a direct child of 'biological_process ; GO:0008150' because some immune system processes are types of cellular process (GO:0009987), whereas others are types of multicellular organism process (GO:0032501). subset: goslim_agr subset: goslim_chembl subset: goslim_flybase_ribbon subset: goslim_generic subset: goslim_mouse subset: goslim_pir xref: Wikipedia:Immune_system is_a: GO:0008150 ! biological_process disjoint_from: GO:0044848 ! biological phase property_value: RO:0002161 NCBITaxon:4895 [Term] id: GO:0002377 name: immunoglobulin production namespace: biological_process def: "The appearance of immunoglobulin due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:add, ISBN:0781735149] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms. subset: gocheck_do_not_annotate synonym: "antibody production" EXACT [] synonym: "immunoglobulin biosynthetic process" NARROW [] synonym: "immunoglobulin secretion" NARROW [] is_a: GO:0002440 ! production of molecular mediator of immune response property_value: RO:0002161 NCBITaxon:4895 [Term] id: GO:0002381 name: immunoglobulin production involved in immunoglobulin-mediated immune response namespace: biological_process def: "The appearance of immunoglobulin due to biosynthesis or secretion following a cellular stimulus during an immune response, resulting in an increase in its intracellular or extracellular levels." [GOC:add, ISBN:0781735149, PMID:9185563] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms. subset: gocheck_do_not_annotate synonym: "antibody production during immune response" RELATED [] synonym: "antibody secretion during immune response" RELATED [] synonym: "immunoglobulin biosynthetic process involved in immune response" NARROW [] synonym: "immunoglobulin production during immune response" RELATED [GOC:dph] synonym: "immunoglobulin production involved in immune response" RELATED [GOC:dph] synonym: "immunoglobulin production involved in immunoglobulin mediated immune response" EXACT [] synonym: "immunoglobulin secretion involved in immune response" NARROW [] is_a: GO:0002377 ! immunoglobulin production intersection_of: GO:0002377 ! immunoglobulin production intersection_of: BFO:0000050 GO:0016064 ! part of immunoglobulin mediated immune response relationship: BFO:0000050 GO:0016064 ! part of immunoglobulin mediated immune response [Term] id: GO:0002384 name: hepatic immune response namespace: biological_process def: "An immune response taking place in the liver." [GO_REF:0000022, GOC:jal, ISBN:0781735149] is_a: BFO:0000003 is_a: GO:0002251 ! organ or tissue specific immune response intersection_of: GO:0006955 ! immune response intersection_of: BFO:0000066 UBERON:0002107 ! occurs in liver relationship: BFO:0000066 UBERON:0002107 ! occurs in liver relationship: RO:0002162 NCBITaxon:7742 ! in taxon Vertebrata [Term] id: GO:0002385 name: mucosal immune response namespace: biological_process def: "An immune response taking place in mucosal tissues, including those of the intestinal tract, nasal and upper respiratory tract, and genital tract." [GO_REF:0000022, GOC:jal, ISBN:0781735149] synonym: "immune response in MALT" NARROW [] synonym: "immune response in mucosal-associated lymphoid tissue" NARROW [] synonym: "immune response in urogenital tract" NARROW [] is_a: GO:0002251 ! organ or tissue specific immune response property_value: RO:0002161 NCBITaxon:4895 [Term] id: GO:0002387 name: immune response in gut-associated lymphoid tissue namespace: biological_process def: "Immune response taking place in the gut-associated lymphoid tissue (GALT). GALT includes Peyer's patches, appendix, and solitary lymph nodules." [GOC:jal, ISBN:0781735149] synonym: "immune response in GALT" EXACT [] is_a: BFO:0000003 is_a: GO:0006955 ! immune response intersection_of: GO:0006955 ! immune response intersection_of: BFO:0000066 UBERON:0001962 ! occurs in gut-associated lymphoid tissue relationship: BFO:0000066 UBERON:0001962 ! occurs in gut-associated lymphoid tissue property_value: RO:0002161 NCBITaxon:4895 [Term] id: GO:0002388 name: immune response in Peyer's patch namespace: biological_process def: "Immune response taking place in the Peyer's patch, nodular lymphoid structures on the serosal surface of the small intestine." [GOC:jal, ISBN:0781735149] is_a: GO:0002387 ! immune response in gut-associated lymphoid tissue intersection_of: GO:0006955 ! immune response intersection_of: BFO:0000066 UBERON:0001211 ! occurs in Peyer's patch relationship: BFO:0000066 UBERON:0001211 ! occurs in Peyer's patch relationship: RO:0002162 NCBITaxon:32524 ! in taxon Amniota [Term] id: GO:0002389 name: tolerance induction in Peyer's patch namespace: biological_process def: "Tolerance induction taking place in the Peyer's patches." [GOC:jal, ISBN:0781735149] is_a: GO:0002388 ! immune response in Peyer's patch is_a: GO:0002394 ! tolerance induction in gut-associated lymphoid tissue intersection_of: GO:0002507 ! tolerance induction intersection_of: BFO:0000066 UBERON:0001211 ! occurs in Peyer's patch [Term] id: GO:0002394 name: tolerance induction in gut-associated lymphoid tissue namespace: biological_process def: "Tolerance induction taking place in the gut-associated lymphoid tissue (GALT)." [GOC:jal, ISBN:0781735149] synonym: "oral tolerance" RELATED [] synonym: "tolerance induction in GALT" EXACT [] is_a: GO:0002387 ! immune response in gut-associated lymphoid tissue is_a: GO:0002401 ! tolerance induction in mucosal-associated lymphoid tissue intersection_of: GO:0002507 ! tolerance induction intersection_of: BFO:0000066 UBERON:0001962 ! occurs in gut-associated lymphoid tissue [Term] id: GO:0002395 name: immune response in nasopharyngeal-associated lymphoid tissue namespace: biological_process def: "An immune response taking place in the nasopharyngeal-associated lymphoid tissue (NALT). NALT includes the tonsils and adenoids." [GOC:jal, ISBN:0781735149] synonym: "immune response in NALT" EXACT [] is_a: GO:0002387 ! immune response in gut-associated lymphoid tissue intersection_of: GO:0006955 ! immune response intersection_of: BFO:0000066 UBERON:0012330 ! occurs in nasal-associated lymphoid tissue relationship: BFO:0000066 UBERON:0012330 ! occurs in nasal-associated lymphoid tissue property_value: RO:0002161 NCBITaxon:4895 [Term] id: GO:0002396 name: MHC protein complex assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form an MHC protein complex." [GOC:add, ISBN:0781735149, PMID:15771591, PMID:15928678] is_a: GO:0065003 ! protein-containing complex assembly intersection_of: GO:0022607 ! cellular component assembly intersection_of: RO:0002588 GO:0042611 ! results in assembly of MHC protein complex relationship: RO:0002588 GO:0042611 ! results in assembly of MHC protein complex [Term] id: GO:0002399 name: MHC class II protein complex assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form an MHC class II protein complex." [GOC:add, ISBN:0781735149, PMID:15771591] is_a: GO:0002396 ! MHC protein complex assembly intersection_of: GO:0022607 ! cellular component assembly intersection_of: RO:0002588 GO:0042613 ! results in assembly of MHC class II protein complex relationship: RO:0002588 GO:0042613 ! results in assembly of MHC class II protein complex [Term] id: GO:0002400 name: tolerance induction in nasopharyngeal-associated lymphoid tissue namespace: biological_process def: "Tolerance induction taking place in the nasopharyngeal-associated lymphoid tissue (NALT)." [GOC:jal, ISBN:0781735149] synonym: "nasal tolerance" RELATED [] synonym: "tolerance induction in NALT" EXACT [] is_a: GO:0002394 ! tolerance induction in gut-associated lymphoid tissue is_a: GO:0002395 ! immune response in nasopharyngeal-associated lymphoid tissue intersection_of: GO:0002507 ! tolerance induction intersection_of: BFO:0000066 UBERON:0012330 ! occurs in nasal-associated lymphoid tissue [Term] id: GO:0002401 name: tolerance induction in mucosal-associated lymphoid tissue namespace: biological_process def: "Tolerance induction taking place in the mucosal-associated lymphoid tissue (MALT)." [GOC:jal, ISBN:0781735149] synonym: "tolerance induction in MALT" EXACT [] is_a: BFO:0000003 is_a: GO:0002427 ! mucosal tolerance induction intersection_of: GO:0002507 ! tolerance induction intersection_of: BFO:0000066 UBERON:0001961 ! occurs in mucosa-associated lymphoid tissue relationship: BFO:0000066 UBERON:0001961 ! occurs in mucosa-associated lymphoid tissue [Term] id: GO:0002402 name: B cell tolerance induction in mucosal-associated lymphoid tissue namespace: biological_process def: "Tolerance induction taking place in the mucosal-associated lymphoid tissue (MALT) mediated by B cells." [GOC:jal, ISBN:0781735149] synonym: "B cell tolerance induction in MALT" EXACT [] is_a: GO:0002401 ! tolerance induction in mucosal-associated lymphoid tissue is_a: GO:0002451 ! peripheral B cell tolerance induction intersection_of: GO:0002401 ! tolerance induction in mucosal-associated lymphoid tissue intersection_of: RO:0002608 CL:0000236 ! process has causal agent B cell [Term] id: GO:0002403 name: T cell tolerance induction in mucosal-associated lymphoid tissue namespace: biological_process def: "Tolerance induction taking place in the mucosal-associated lymphoid tissue (MALT) mediated by T cells." [GOC:jal, ISBN:0781735149, PMID:16551263] synonym: "T cell tolerance induction in MALT" EXACT [] is_a: GO:0002401 ! tolerance induction in mucosal-associated lymphoid tissue is_a: GO:0002458 ! peripheral T cell tolerance induction intersection_of: GO:0002401 ! tolerance induction in mucosal-associated lymphoid tissue intersection_of: RO:0002608 CL:0000084 ! process has causal agent T cell [Term] id: GO:0002407 name: dendritic cell chemotaxis namespace: biological_process def: "The movement of a dendritic cell in response to an external stimulus." [CL:0000451, GOC:add, ISBN:0781735149, PMID:15814331, PMID:16056255] is_a: GO:0030595 ! leukocyte chemotaxis is_a: GO:0036336 ! dendritic cell migration intersection_of: GO:0006935 ! chemotaxis intersection_of: RO:0002565 CL:0000451 ! results in movement of dendritic cell [Term] id: GO:0002408 name: myeloid dendritic cell chemotaxis namespace: biological_process def: "The movement of a myeloid dendritic cell in response to an external stimulus." [GOC:add, ISBN:0781735149, PMID:15814331, PMID:16056255] is_a: GO:0002407 ! dendritic cell chemotaxis is_a: GO:0097529 ! myeloid leukocyte migration intersection_of: GO:0006935 ! chemotaxis intersection_of: RO:0002565 CL:0000782 ! results in movement of myeloid dendritic cell relationship: RO:0002565 CL:0000782 ! results in movement of myeloid dendritic cell [Term] id: GO:0002409 name: Langerhans cell chemotaxis namespace: biological_process def: "The movement of a Langerhans cell in response to an external stimulus." [GOC:add, PMID:16056255, PMID:16387601] is_a: GO:0002408 ! myeloid dendritic cell chemotaxis intersection_of: GO:0006935 ! chemotaxis intersection_of: RO:0002565 CL:0000453 ! results in movement of Langerhans cell relationship: RO:0002565 CL:0000453 ! results in movement of Langerhans cell [Term] id: GO:0002410 name: plasmacytoid dendritic cell chemotaxis namespace: biological_process def: "The movement of a plasmacytoid dendritic cell in response to an external stimulus." [GOC:add, PMID:15159375, PMID:15814331] is_a: GO:0002407 ! dendritic cell chemotaxis intersection_of: GO:0006935 ! chemotaxis intersection_of: RO:0002565 CL:0000784 ! results in movement of plasmacytoid dendritic cell relationship: RO:0002565 CL:0000784 ! results in movement of plasmacytoid dendritic cell [Term] id: GO:0002427 name: mucosal tolerance induction namespace: biological_process def: "Tolerance induction taking place in the mucosal tissues." [GOC:jal] is_a: GO:0002385 ! mucosal immune response is_a: GO:0002462 ! tolerance induction to nonself antigen [Term] id: GO:0002432 name: granuloma formation namespace: biological_process def: "The formation of nodular inflammatory lesions, usually small or granular, firm, persistent, well-structured, and containing compactly grouped T lymphocytes and modified phagocytes such as epithelioid cells, giant cells, and other macrophages. Granuloma formation represents a chronic inflammatory response initiated by various infectious and noninfectious agents. The center of a granuloma consists of fused macrophages, which can become necrotic." [GO_REF:0000022, GOC:add, ISBN:068340007X, ISBN:0721601464, ISBN:081533642X] is_a: GO:0002252 ! immune effector process relationship: BFO:0000050 GO:0002544 ! part of chronic inflammatory response [Term] id: GO:0002440 name: production of molecular mediator of immune response namespace: biological_process def: "The synthesis or release of any molecular mediator of the immune response, resulting in an increase in its intracellular or extracellular levels." [GO_REF:0000022, GOC:add, ISBN:0781735149] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms. subset: gocheck_do_not_annotate synonym: "production of cellular mediator of immune response" RELATED [] is_a: GO:0002376 ! immune system process is_a: GO:0010467 ! gene expression property_value: RO:0002161 NCBITaxon:4895 [Term] id: GO:0002441 name: histamine secretion involved in inflammatory response namespace: biological_process def: "The regulated release of histamine by a cell as part of an inflammatory response." [GOC:add, ISBN:0781735149] synonym: "histamine secretion involved in acute inflammatory response" BROAD [] is_a: GO:0001821 ! histamine secretion is_a: GO:0046879 ! hormone secretion intersection_of: GO:0001821 ! histamine secretion intersection_of: BFO:0000050 GO:0006954 ! part of inflammatory response relationship: BFO:0000050 GO:0002349 ! part of histamine production involved in inflammatory response [Term] id: GO:0002442 name: serotonin secretion involved in inflammatory response namespace: biological_process def: "The regulated release of serotonin by a cell as part of an inflammatory response." [GOC:add, ISBN:0781735149] synonym: "serotonin release involved in inflammatory response" RELATED [GOC:tb] synonym: "serotonin secretion involved in acute inflammatory response" BROAD [] is_a: GO:0001820 ! serotonin secretion intersection_of: GO:0001820 ! serotonin secretion intersection_of: BFO:0000050 GO:0006954 ! part of inflammatory response relationship: BFO:0000050 GO:0002351 ! part of serotonin production involved in inflammatory response [Term] id: GO:0002443 name: leukocyte mediated immunity namespace: biological_process def: "Any process involved in the carrying out of an immune response by a leukocyte." [GO_REF:0000022, GOC:add, ISBN:0781735149] synonym: "cell-mediated immune response" RELATED [] synonym: "cellular immune response" RELATED [] synonym: "immune cell effector process" EXACT [] synonym: "immune cell mediated immunity" EXACT [] synonym: "leucocyte immune effector process" EXACT [] synonym: "leucocyte mediated immunity" EXACT [] synonym: "leukocyte immune effector process" EXACT [] is_a: GO:0002252 ! immune effector process intersection_of: GO:0002376 ! immune system process intersection_of: RO:0002608 CL:0000738 ! process has causal agent leukocyte relationship: RO:0002162 NCBITaxon:7742 ! in taxon Vertebrata relationship: RO:0002608 CL:0000738 ! process has causal agent leukocyte [Term] id: GO:0002444 name: myeloid leukocyte mediated immunity namespace: biological_process def: "Any process involved in the carrying out of an immune response by a myeloid leukocyte." [GO_REF:0000022, GOC:add, ISBN:0781735149] synonym: "myeloid leucocyte immune effector process" EXACT [] synonym: "myeloid leucocyte mediated immunity" EXACT [] synonym: "myeloid leukocyte immune effector process" EXACT [] is_a: GO:0002443 ! leukocyte mediated immunity intersection_of: GO:0002376 ! immune system process intersection_of: RO:0002608 CL:0000766 ! process has causal agent myeloid leukocyte relationship: RO:0002608 CL:0000766 ! process has causal agent myeloid leukocyte [Term] id: GO:0002446 name: neutrophil mediated immunity namespace: biological_process def: "Any process involved in the carrying out of an immune response by a neutrophil." [GO_REF:0000022, GOC:add, ISBN:0781735149] is_a: GO:0002444 ! myeloid leukocyte mediated immunity intersection_of: GO:0002376 ! immune system process intersection_of: RO:0002608 CL:0000775 ! process has causal agent neutrophil relationship: RO:0002608 CL:0000775 ! process has causal agent neutrophil [Term] id: GO:0002447 name: eosinophil mediated immunity namespace: biological_process def: "Any process involved in the carrying out of an immune response by an eosinophil." [GO_REF:0000022, GOC:add, ISBN:0781735149] is_a: GO:0002444 ! myeloid leukocyte mediated immunity intersection_of: GO:0002376 ! immune system process intersection_of: RO:0002608 CL:0000771 ! process has causal agent eosinophil relationship: RO:0002608 CL:0000771 ! process has causal agent eosinophil [Term] id: GO:0002448 name: mast cell mediated immunity namespace: biological_process def: "Any process involved in the carrying out of an immune response by a mast cell." [GO_REF:0000022, GOC:add, ISBN:0781735149] is_a: GO:0002444 ! myeloid leukocyte mediated immunity intersection_of: GO:0002376 ! immune system process intersection_of: RO:0002608 CL:0000097 ! process has causal agent mast cell relationship: RO:0002608 CL:0000097 ! process has causal agent mast cell [Term] id: GO:0002449 name: lymphocyte mediated immunity namespace: biological_process def: "Any process involved in the carrying out of an immune response by a lymphocyte." [GO_REF:0000022, GOC:add, ISBN:0781735149] synonym: "cell-mediated immunity" BROAD [] synonym: "cellular immune response" BROAD [] is_a: GO:0002443 ! leukocyte mediated immunity intersection_of: GO:0002376 ! immune system process intersection_of: RO:0002608 CL:0000542 ! process has causal agent lymphocyte relationship: RO:0002608 CL:0000542 ! process has causal agent lymphocyte [Term] id: GO:0002450 name: B cell antigen processing and presentation namespace: biological_process def: "The process in which a B cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex." [GOC:add, ISBN:0781735149, PMID:15771591] synonym: "B lymphocyte antigen processing and presentation" EXACT [] synonym: "B-cell antigen processing and presentation" EXACT [] synonym: "B-lymphocyte antigen processing and presentation" EXACT [] is_a: BFO:0000003 is_a: GO:0019882 ! antigen processing and presentation intersection_of: GO:0019882 ! antigen processing and presentation intersection_of: BFO:0000066 CL:0000236 ! occurs in B cell relationship: BFO:0000050 GO:0019724 ! part of B cell mediated immunity relationship: BFO:0000066 CL:0000236 ! occurs in B cell [Term] id: GO:0002451 name: peripheral B cell tolerance induction namespace: biological_process def: "Tolerance induction of mature B cells in the peripheral lymphoid tissues: the blood, lymph nodes, spleen, and mucosal-associated lymphoid tissue." [GOC:jal, ISBN:0781735149] synonym: "peripheral B lymphocyte tolerance induction" EXACT [] synonym: "peripheral B-cell tolerance induction" EXACT [] synonym: "peripheral B-lymphocyte tolerance induction" EXACT [] is_a: GO:0002465 ! peripheral tolerance induction is_a: GO:0002514 ! B cell tolerance induction is_a: GO:0019724 ! B cell mediated immunity [Term] id: GO:0002456 name: T cell mediated immunity namespace: biological_process def: "Any process involved in the carrying out of an immune response by a T cell." [GO_REF:0000022, GOC:add, ISBN:0781735149] synonym: "cell-mediated immunity" BROAD [] synonym: "cellular immune response" BROAD [] synonym: "T lymphocyte mediated immunity" EXACT [] synonym: "T-cell mediated immunity" EXACT [] synonym: "T-lymphocyte mediated immunity" EXACT [] is_a: GO:0002449 ! lymphocyte mediated immunity is_a: GO:0002460 ! adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains intersection_of: GO:0002376 ! immune system process intersection_of: RO:0002608 CL:0000084 ! process has causal agent T cell relationship: RO:0002608 CL:0000084 ! process has causal agent T cell [Term] id: GO:0002457 name: T cell antigen processing and presentation namespace: biological_process def: "The process in which a T cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex." [GOC:add, PMID:11417857, PMID:15120183] synonym: "T lymphocyte antigen processing and presentation" EXACT [] synonym: "T-cell antigen processing and presentation" EXACT [] synonym: "T-lymphocyte antigen processing and presentation" EXACT [] is_a: BFO:0000003 is_a: GO:0019882 ! antigen processing and presentation intersection_of: GO:0019882 ! antigen processing and presentation intersection_of: BFO:0000066 CL:0000084 ! occurs in T cell relationship: BFO:0000050 GO:0002456 ! part of T cell mediated immunity relationship: BFO:0000066 CL:0000084 ! occurs in T cell [Term] id: GO:0002458 name: peripheral T cell tolerance induction namespace: biological_process def: "Tolerance induction of T cells in the periphery, in this case, any location in the body other than the thymus." [GOC:jal, ISBN:0781735149] synonym: "peripheral T lymphocyte tolerance induction" EXACT [] synonym: "peripheral T-cell tolerance induction" EXACT [] synonym: "peripheral T-lymphocyte tolerance induction" EXACT [] is_a: GO:0002456 ! T cell mediated immunity is_a: GO:0002465 ! peripheral tolerance induction is_a: GO:0002517 ! T cell tolerance induction [Term] id: GO:0002460 name: adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains namespace: biological_process def: "An immune response mediated by lymphocytes expressing specific receptors for antigen produced through a somatic diversification process that includes somatic recombination of germline gene segments encoding immunoglobulin superfamily domains. Recombined receptors for antigen encoded by immunoglobulin superfamily domains include T cell receptors and immunoglobulins (antibodies) produced by B cells. The first encounter with antigen elicits a primary immune response that is slow and not of great magnitude. T and B cells selected by antigen become activated and undergo clonal expansion. A fraction of antigen-reactive T and B cells become memory cells, whereas others differentiate into effector cells. The memory cells generated during the primary response enable a much faster and stronger secondary immune response upon subsequent exposures to the same antigen (immunological memory). An example of this is the adaptive immune response found in Mus musculus." [GOC:add, GOC:mtg_sensu, ISBN:0781735149, ISBN:1405196831] is_a: GO:0002250 ! adaptive immune response [Term] id: GO:0002461 name: tolerance induction dependent upon immune response namespace: biological_process def: "Tolerance induction dependent upon an immune response, typically a response by a mature T or B cell in the periphery resulting tolerance towards an antigen via induction of anergy, cellular deletion, or regulatory T cell activation." [GO_REF:0000022, GOC:jal, ISBN:0781735149] synonym: "immune response-dependent tolerance induction" EXACT [] is_a: GO:0002460 ! adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains is_a: GO:0002507 ! tolerance induction [Term] id: GO:0002462 name: tolerance induction to nonself antigen namespace: biological_process def: "Tolerance induction in response to nonself antigens." [GO_REF:0000022, GOC:jal, ISBN:0781735149] is_a: GO:0002461 ! tolerance induction dependent upon immune response [Term] id: GO:0002465 name: peripheral tolerance induction namespace: biological_process def: "Tolerance induction in the peripheral lymphoid tissues: blood, lymph nodes, spleen, and mucosal-associated lymphoid tissues." [GO_REF:0000022, GOC:jal, ISBN:0781735149] is_a: GO:0002461 ! tolerance induction dependent upon immune response [Term] id: GO:0002467 name: germinal center formation namespace: biological_process def: "The process in which germinal centers form. A germinal center is a specialized microenvironment formed when activated B cells enter lymphoid follicles. Germinal centers are the foci for B cell proliferation and somatic hypermutation." [GO_REF:0000022, GOC:jal, ISBN:081533642X] is_a: BFO:0000003 is_a: GO:0002460 ! adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0001745 ! results in formation of anatomical entity secondary nodular lymphoid tissue relationship: RO:0002297 UBERON:0001745 ! results in formation of anatomical entity secondary nodular lymphoid tissue [Term] id: GO:0002468 name: dendritic cell antigen processing and presentation namespace: biological_process def: "The process in which a dendritic cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex." [GOC:add, ISBN:0781735149, PMID:15771591] is_a: BFO:0000003 is_a: GO:0019882 ! antigen processing and presentation intersection_of: GO:0019882 ! antigen processing and presentation intersection_of: BFO:0000066 CL:0000451 ! occurs in dendritic cell relationship: BFO:0000066 CL:0000451 ! occurs in dendritic cell property_value: RO:0002161 NCBITaxon:4895 [Term] id: GO:0002469 name: myeloid dendritic cell antigen processing and presentation namespace: biological_process def: "The process in which a myeloid dendritic cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex." [GOC:add, ISBN:0781735149, PMID:15771591] is_a: GO:0002468 ! dendritic cell antigen processing and presentation intersection_of: GO:0019882 ! antigen processing and presentation intersection_of: BFO:0000066 CL:0000782 ! occurs in myeloid dendritic cell relationship: BFO:0000066 CL:0000782 ! occurs in myeloid dendritic cell property_value: RO:0002161 NCBITaxon:4895 [Term] id: GO:0002470 name: plasmacytoid dendritic cell antigen processing and presentation namespace: biological_process def: "The process in which a plasmacytoid dendritic cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex." [GOC:add, ISBN:0781735149, PMID:15771591] is_a: GO:0002468 ! dendritic cell antigen processing and presentation intersection_of: GO:0019882 ! antigen processing and presentation intersection_of: BFO:0000066 CL:0000784 ! occurs in plasmacytoid dendritic cell relationship: BFO:0000066 CL:0000784 ! occurs in plasmacytoid dendritic cell property_value: RO:0002161 NCBITaxon:4895 [Term] id: GO:0002471 name: monocyte antigen processing and presentation namespace: biological_process def: "The process in which a monocyte expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex." [GOC:add, PMID:11200054] is_a: BFO:0000003 is_a: GO:0019882 ! antigen processing and presentation intersection_of: GO:0019882 ! antigen processing and presentation intersection_of: BFO:0000066 CL:0000576 ! occurs in monocyte relationship: BFO:0000066 CL:0000576 ! occurs in monocyte property_value: RO:0002161 NCBITaxon:4895 [Term] id: GO:0002472 name: macrophage antigen processing and presentation namespace: biological_process def: "The process in which a macrophage expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex." [GOC:add, ISBN:0781735149, PMID:15771591] is_a: BFO:0000003 is_a: GO:0019882 ! antigen processing and presentation intersection_of: GO:0019882 ! antigen processing and presentation intersection_of: BFO:0000066 CL:0000235 ! occurs in macrophage relationship: BFO:0000066 CL:0000235 ! occurs in macrophage property_value: RO:0002161 NCBITaxon:4895 [Term] id: GO:0002474 name: antigen processing and presentation of peptide antigen via MHC class I namespace: biological_process def: "The process in which an antigen-presenting cell expresses a peptide antigen on its cell surface in association with an MHC class I protein complex. Class I here refers to classical class I molecules." [GOC:add, ISBN:0781735149, PMID:15224092, PMID:15771591] synonym: "peptide antigen processing and presentation via MHC class I" EXACT [] xref: Reactome:R-HSA-983169 "Class I MHC mediated antigen processing & presentation" is_a: GO:0048002 ! antigen processing and presentation of peptide antigen property_value: RO:0002161 NCBITaxon:4895 [Term] id: GO:0002478 name: antigen processing and presentation of exogenous peptide antigen namespace: biological_process def: "The process in which an antigen-presenting cell expresses a peptide antigen of exogenous origin on its cell surface in association with an MHC protein complex. The peptide is typically a fragment of a larger exogenous protein which has been degraded within the cell." [GOC:add, ISBN:0781735149] synonym: "exogenous peptide antigen processing and presentation" EXACT [] is_a: GO:0019884 ! antigen processing and presentation of exogenous antigen is_a: GO:0048002 ! antigen processing and presentation of peptide antigen property_value: RO:0002161 NCBITaxon:4895 [Term] id: GO:0002483 name: antigen processing and presentation of endogenous peptide antigen namespace: biological_process def: "The process in which an antigen-presenting cell expresses a peptide antigen of endogenous origin on its cell surface in association with an MHC protein complex. The peptide is typically a fragment of a larger endogenous protein which has been degraded within the cell." [GOC:add, ISBN:0781735149] synonym: "endogenous peptide antigen processing and presentation" EXACT [] is_a: GO:0019883 ! antigen processing and presentation of endogenous antigen is_a: GO:0048002 ! antigen processing and presentation of peptide antigen property_value: RO:0002161 NCBITaxon:4895 [Term] id: GO:0002491 name: antigen processing and presentation of endogenous peptide antigen via MHC class II namespace: biological_process def: "The process in which an antigen-presenting cell expresses a peptide antigen of endogenous origin on its cell surface in association with an MHC class II protein complex. The peptide antigen is typically, but not always, processed from a whole protein." [GOC:add, PMID:15531770, PMID:16181338] synonym: "endogenous peptide antigen processing and presentation via MHC class II" EXACT [] is_a: GO:0002483 ! antigen processing and presentation of endogenous peptide antigen is_a: GO:0002495 ! antigen processing and presentation of peptide antigen via MHC class II property_value: RO:0002161 NCBITaxon:4895 [Term] id: GO:0002495 name: antigen processing and presentation of peptide antigen via MHC class II namespace: biological_process def: "The process in which an antigen-presenting cell expresses a peptide antigen on its cell surface in association with an MHC class II protein complex. The peptide antigen is typically, but not always, processed from a whole protein." [GOC:add, ISBN:0781735149, PMID:15531770, PMID:15771591] synonym: "peptide antigen processing and presentation via MHC class II" EXACT [] is_a: GO:0002504 ! antigen processing and presentation of peptide or polysaccharide antigen via MHC class II is_a: GO:0048002 ! antigen processing and presentation of peptide antigen property_value: RO:0002161 NCBITaxon:4895 [Term] id: GO:0002496 name: proteolysis associated with antigen processing and presentation namespace: biological_process def: "The hydrolysis of a peptide bond or bonds within a protein contributing to antigen processing and presentation." [GOC:add, ISBN:0781735149, PMID:15224092, PMID:15771591] is_a: GO:0051603 ! proteolysis involved in protein catabolic process intersection_of: GO:0006508 ! proteolysis intersection_of: BFO:0000050 GO:0048002 ! part of antigen processing and presentation of peptide antigen relationship: BFO:0000050 GO:0048002 ! part of antigen processing and presentation of peptide antigen property_value: RO:0002161 NCBITaxon:4895 [Term] id: GO:0002500 name: proteolysis within lysosome associated with antigen processing and presentation namespace: biological_process def: "The hydrolysis of a peptide bond or bonds within a protein by lysosomal resident proteases contributing to antigen processing and presentation." [GOC:add, ISBN:0781735149, PMID:15771591] synonym: "lysosomal proteolysis associated with antigen processing and presentation" EXACT [] is_a: GO:0002496 ! proteolysis associated with antigen processing and presentation intersection_of: GO:0002496 ! proteolysis associated with antigen processing and presentation intersection_of: BFO:0000066 GO:0005764 ! occurs in lysosome relationship: BFO:0000066 GO:0005764 ! occurs in lysosome property_value: RO:0002161 NCBITaxon:4895 [Term] id: GO:0002504 name: antigen processing and presentation of peptide or polysaccharide antigen via MHC class II namespace: biological_process def: "The process in which an antigen-presenting cell expresses antigen (peptide or polysaccharide) on its cell surface in association with an MHC class II protein complex." [GOC:add, ISBN:0781735149, PMID:15531770, PMID:15771591, PMID:16153240] synonym: "peptide or polysaccharide antigen processing and presentation of via MHC class II" EXACT [] is_a: GO:0019882 ! antigen processing and presentation property_value: RO:0002161 NCBITaxon:4895 [Term] id: GO:0002507 name: tolerance induction namespace: biological_process def: "A process that directly activates any of the steps required for tolerance, a physiologic state in which the immune system does not react destructively against the components of an organism that harbors it or against antigens that are introduced to it." [GO_REF:0000022, GOC:jal, ISBN:0781735149] is_a: GO:0002376 ! immune system process relationship: BFO:0000050 GO:0002520 ! part of immune system development property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4895 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0002514 name: B cell tolerance induction namespace: biological_process def: "A process involving any mechanism for tolerance induction in B cells." [GOC:jal, ISBN:0781735149, PMID:16460922] synonym: "B lymphocyte tolerance induction" EXACT [] synonym: "B-cell tolerance induction" EXACT [] synonym: "B-lymphocyte tolerance induction" EXACT [] is_a: BFO:0000003 is_a: GO:0002507 ! tolerance induction intersection_of: GO:0002507 ! tolerance induction intersection_of: BFO:0000066 CL:0000236 ! occurs in B cell relationship: BFO:0000066 CL:0000236 ! occurs in B cell property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4895 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0002515 name: B cell anergy namespace: biological_process def: "Any process contributing to anergy in B cells, a state of functional inactivation which is part of B cell tolerance induction." [GOC:jal, ISBN:0781735149] synonym: "B lymphocyte anergy" EXACT [] synonym: "B-cell anergy" EXACT [] synonym: "B-lymphocyte anergy" EXACT [] is_a: GO:0002249 ! lymphocyte anergy is_a: GO:0002514 ! B cell tolerance induction intersection_of: GO:0002249 ! lymphocyte anergy intersection_of: RO:0004009 CL:0000236 ! has primary input B cell relationship: RO:0004009 CL:0000236 ! has primary input B cell property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4895 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0002516 name: B cell deletion namespace: biological_process def: "The apoptotic death of B cells which is part of B cell tolerance induction." [GOC:add, GOC:jal, ISBN:0781735149] synonym: "B lymphocyte deletion" EXACT [] synonym: "B-cell deletion" EXACT [] synonym: "B-lymphocyte deletion" EXACT [] is_a: GO:0001783 ! B cell apoptotic process is_a: GO:1902742 ! apoptotic process involved in development intersection_of: GO:0001783 ! B cell apoptotic process intersection_of: BFO:0000050 GO:0002514 ! part of B cell tolerance induction relationship: BFO:0000050 GO:0002514 ! part of B cell tolerance induction [Term] id: GO:0002517 name: T cell tolerance induction namespace: biological_process def: "A process involving any mechanism for tolerance induction in T cells." [GOC:jal, ISBN:0781735149, PMID:16551263] synonym: "T lymphocyte tolerance induction" EXACT [] synonym: "T-cell tolerance induction" EXACT [] synonym: "T-lymphocyte tolerance induction" EXACT [] is_a: BFO:0000003 is_a: GO:0002507 ! tolerance induction intersection_of: GO:0002507 ! tolerance induction intersection_of: BFO:0000066 CL:0000084 ! occurs in T cell relationship: BFO:0000066 CL:0000084 ! occurs in T cell property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4895 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0002519 name: natural killer cell tolerance induction namespace: biological_process def: "Tolerance induction of natural killer cells." [GOC:jal, PMID:16546094] synonym: "NK cell tolerance induction" EXACT [] is_a: BFO:0000003 is_a: GO:0002507 ! tolerance induction intersection_of: GO:0002507 ! tolerance induction intersection_of: BFO:0000066 CL:0000623 ! occurs in natural killer cell relationship: BFO:0000066 CL:0000623 ! occurs in natural killer cell property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4895 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0002520 name: immune system development namespace: biological_process def: "The process whose specific outcome is the progression of an organismal system whose objective is to provide calibrated responses by an organism to a potential internal or invasive threat, over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process." [GOC:add, GOC:dph] subset: goslim_drosophila is_a: GO:0002376 ! immune system process is_a: GO:0048731 ! system development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0002405 ! results in development of immune system relationship: RO:0002296 UBERON:0002405 ! results in development of immune system property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4895 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0002521 name: leukocyte differentiation namespace: biological_process def: "The process in which a relatively unspecialized hemopoietic precursor cell acquires the specialized features of a leukocyte. A leukocyte is an achromatic cell of the myeloid or lymphoid lineages capable of ameboid movement, found in blood or other tissue." [CL:0000738, GOC:add, PMID:16551264] synonym: "immune cell differentiation" EXACT [] synonym: "leucocyte differentiation" EXACT [] is_a: GO:0030154 ! cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000738 ! results in acquisition of features of leukocyte relationship: BFO:0000050 GO:0030097 ! part of hemopoiesis relationship: RO:0002315 CL:0000738 ! results in acquisition of features of leukocyte [Term] id: GO:0002522 name: leukocyte migration involved in immune response namespace: biological_process def: "The movement of a leukocyte within or between different tissues and organs of the body as part of an immune response." [GOC:add, ISBN:0781735149, PMID:14680625, PMID:14708592, PMID:7507411, PMID:8600538] synonym: "immune cell migration during immune response" EXACT [] synonym: "immune cell trafficking during immune response" EXACT [] synonym: "leucocyte migration during immune response" EXACT [] synonym: "leucocyte trafficking during immune response" EXACT [] synonym: "leukocyte trafficking during immune response" EXACT [] is_a: GO:0002252 ! immune effector process is_a: GO:0050900 ! leukocyte migration intersection_of: GO:0050900 ! leukocyte migration intersection_of: BFO:0000050 GO:0006955 ! part of immune response relationship: BFO:0000050 GO:0006955 ! part of immune response [Term] id: GO:0002523 name: leukocyte migration involved in inflammatory response namespace: biological_process def: "The movement of a leukocyte within or between different tissues and organs of the body contributing to an inflammatory response." [GOC:add, ISBN:0781735149, PMID:14680625, PMID:14708592, PMID:7507411, PMID:8600538] synonym: "immune cell migration during inflammatory response" RELATED [] synonym: "immune cell trafficking during inflammatory response" RELATED [] synonym: "leucocyte migration during inflammatory response" RELATED [] synonym: "leucocyte trafficking during inflammatory response" RELATED [] synonym: "leukocyte migration during inflammatory response" RELATED [GOC:dph] synonym: "leukocyte trafficking during inflammatory response" RELATED [] is_a: GO:0050900 ! leukocyte migration intersection_of: GO:0050900 ! leukocyte migration intersection_of: BFO:0000050 GO:0006954 ! part of inflammatory response relationship: BFO:0000050 GO:0006954 ! part of inflammatory response [Term] id: GO:0002526 name: acute inflammatory response namespace: biological_process def: "Inflammation which comprises a rapid, short-lived, relatively uniform response to acute injury or antigenic challenge and is characterized by accumulations of fluid, plasma proteins, and granulocytic leukocytes. An acute inflammatory response occurs within a matter of minutes or hours, and either resolves within a few days or becomes a chronic inflammatory response." [GO_REF:0000022, GOC:add, ISBN:0781735149] is_a: GO:0006954 ! inflammatory response [Term] id: GO:0002528 name: regulation of vascular permeability involved in acute inflammatory response namespace: biological_process def: "Any process that modulates the extent to which blood vessels can be pervaded by fluid contributing to an acute inflammatory response." [GOC:jal] synonym: "regulation of vascular permeability during acute inflammatory response" RELATED [GOC:dph] is_a: GO:0043114 ! regulation of vascular permeability intersection_of: GO:0043114 ! regulation of vascular permeability intersection_of: BFO:0000050 GO:0002526 ! part of acute inflammatory response relationship: BFO:0000050 GO:0002526 ! part of acute inflammatory response [Term] id: GO:0002532 name: production of molecular mediator involved in inflammatory response namespace: biological_process def: "The synthesis or release of any molecular mediator of the inflammatory response following an inflammatory stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:add, GOC:dph, GOC:tb, ISBN:0781735149] synonym: "production of cellular mediator of acute inflammation" RELATED [] synonym: "production of molecular mediator involved in acute inflammatory response" BROAD [] is_a: GO:0032501 ! multicellular organismal process relationship: BFO:0000050 GO:0006954 ! part of inflammatory response [Term] id: GO:0002534 name: cytokine production involved in inflammatory response namespace: biological_process def: "The synthesis or release of a cytokine following a inflammatory stimulus as part of an inflammatory response, resulting in an increase in its intracellular or extracellular levels." [GOC:add, ISBN:0781735149] subset: gocheck_do_not_annotate synonym: "cytokine production involved in acute inflammatory response" BROAD [] is_a: GO:0001816 ! cytokine production is_a: GO:0002532 ! production of molecular mediator involved in inflammatory response intersection_of: GO:0001816 ! cytokine production intersection_of: BFO:0000050 GO:0006954 ! part of inflammatory response [Term] id: GO:0002536 name: respiratory burst involved in inflammatory response namespace: biological_process def: "A phase of elevated metabolic activity, during which oxygen consumption increases following a stimulus as part of an inflammatory response; this leads to the production, by an NADH dependent system, of hydrogen peroxide (H2O2), superoxide anions and hydroxyl radicals, resulting in an increase in their intracellular or extracellular levels." [GOC:add, ISBN:0781735149] synonym: "oxidative burst during acute inflammatory response" BROAD [] synonym: "production of reactive oxygen species during acute inflammatory response" BROAD [] synonym: "respiratory burst involved in acute inflammatory response" BROAD [] is_a: GO:0002532 ! production of molecular mediator involved in inflammatory response is_a: GO:0002679 ! respiratory burst involved in defense response intersection_of: GO:0045730 ! respiratory burst intersection_of: BFO:0000050 GO:0006954 ! part of inflammatory response [Term] id: GO:0002537 name: nitric oxide production involved in inflammatory response namespace: biological_process def: "The synthesis or release of nitric oxide following a stimulus as part of an inflammatory response, resulting in an increase in its intracellular or extracellular levels." [GOC:add, ISBN:0781735149] synonym: "nitric oxide production involved in acute inflammatory response" BROAD [GOC:mah] synonym: "production of nitric oxide involved in acute inflammatory response" BROAD [] synonym: "production of nitric oxide involved in inflammatory response" EXACT [] is_a: GO:0002532 ! production of molecular mediator involved in inflammatory response [Term] id: GO:0002538 name: arachidonate metabolite production involved in inflammatory response namespace: biological_process def: "The synthesis or release of products of arachidonic acid metabolism following a stimulus as part of an inflammatory response, resulting in an increase in their intracellular or extracellular levels." [GOC:add, ISBN:0781735149] synonym: "arachidonic acid metabolite production involved in acute inflammatory response" BROAD [GOC:mah] synonym: "arachidonic acid metabolite production involved in inflammatory response" EXACT [] synonym: "production of arachidonic acid metabolites involved in acute inflammatory response" BROAD [] synonym: "production of arachidonic acid metabolites involved in inflammatory response" EXACT [] is_a: GO:0002532 ! production of molecular mediator involved in inflammatory response property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/28648" xsd:anyURI [Term] id: GO:0002539 name: prostaglandin production involved in inflammatory response namespace: biological_process def: "The synthesis or release of any prostaglandin following a stimulus as part of an inflammatory response, resulting in an increase in its intracellular or extracellular levels." [GOC:add, ISBN:0781735149] synonym: "prostaglandin production involved in acute inflammatory response" BROAD [] is_a: GO:0002538 ! arachidonate metabolite production involved in inflammatory response [Term] id: GO:0002540 name: leukotriene production involved in inflammatory response namespace: biological_process def: "The synthesis or release of any leukotriene following a stimulus as part of an inflammatory response, resulting in an increase in its intracellular or extracellular levels." [GOC:add, ISBN:0781735149] synonym: "leukotriene production involved in acute inflammatory response" BROAD [] is_a: GO:0002538 ! arachidonate metabolite production involved in inflammatory response [Term] id: GO:0002544 name: chronic inflammatory response namespace: biological_process def: "Inflammation of prolonged duration (weeks or months) in which active inflammation, tissue destruction, and attempts at repair are proceeding simultaneously. Although it may follow acute inflammation, chronic inflammation frequently begins insidiously, as a low-grade, smoldering, often asymptomatic response." [GO_REF:0000022, GOC:jal, ISBN:0781735149] is_a: GO:0006954 ! inflammatory response [Term] id: GO:0002548 name: monocyte chemotaxis namespace: biological_process def: "The movement of a monocyte in response to an external stimulus." [GOC:add, PMID:11696603, PMID:15173832] is_a: GO:0030595 ! leukocyte chemotaxis is_a: GO:0071674 ! mononuclear cell migration is_a: GO:0097529 ! myeloid leukocyte migration intersection_of: GO:0006935 ! chemotaxis intersection_of: RO:0002565 CL:0000576 ! results in movement of monocyte relationship: RO:0002565 CL:0000576 ! results in movement of monocyte [Term] id: GO:0002551 name: mast cell chemotaxis namespace: biological_process def: "The movement of a mast cell in response to an external stimulus." [GOC:add, PMID:11292027, PMID:12789214, PMID:16448392] is_a: GO:0030595 ! leukocyte chemotaxis is_a: GO:0097531 ! mast cell migration intersection_of: GO:0006935 ! chemotaxis intersection_of: RO:0002565 CL:0000097 ! results in movement of mast cell [Term] id: GO:0002552 name: serotonin secretion by mast cell namespace: biological_process def: "The regulated release of serotonin by a mast cell or group of mast cells." [GOC:add, ISBN:0781735149] synonym: "serotonin release by mast cell" RELATED [GOC:tb] is_a: GO:0002442 ! serotonin secretion involved in inflammatory response is_a: GO:0051649 ! establishment of localization in cell is_a: GO:0140029 ! exocytic process intersection_of: GO:0001820 ! serotonin secretion intersection_of: RO:0002608 CL:0000097 ! process has causal agent mast cell relationship: BFO:0000050 GO:0043303 ! part of mast cell degranulation relationship: RO:0002608 CL:0000097 ! process has causal agent mast cell [Term] id: GO:0002553 name: histamine secretion by mast cell namespace: biological_process def: "The regulated release of histamine by a mast cell or group of mast cells." [GOC:add, ISBN:0781735149] is_a: GO:0002441 ! histamine secretion involved in inflammatory response is_a: GO:0051649 ! establishment of localization in cell is_a: GO:0140029 ! exocytic process intersection_of: GO:0001821 ! histamine secretion intersection_of: RO:0002608 CL:0000097 ! process has causal agent mast cell relationship: BFO:0000050 GO:0043303 ! part of mast cell degranulation relationship: RO:0002608 CL:0000097 ! process has causal agent mast cell [Term] id: GO:0002554 name: serotonin secretion by platelet namespace: biological_process def: "The regulated release of serotonin by a platelet or group of platelets." [GOC:add, ISBN:0781735149] synonym: "serotonin release by platelet" RELATED [GOC:tb] is_a: GO:0002442 ! serotonin secretion involved in inflammatory response is_a: GO:0051649 ! establishment of localization in cell is_a: GO:0140029 ! exocytic process intersection_of: GO:0001820 ! serotonin secretion intersection_of: RO:0002608 CL:0000233 ! process has causal agent platelet relationship: BFO:0000050 GO:0002576 ! part of platelet degranulation relationship: RO:0002608 CL:0000233 ! process has causal agent platelet [Term] id: GO:0002555 name: histamine secretion by platelet namespace: biological_process def: "The regulated release of histamine by a platelet or group of platelets." [GOC:add, PMID:9117517] is_a: GO:0002441 ! histamine secretion involved in inflammatory response is_a: GO:0051649 ! establishment of localization in cell is_a: GO:0140029 ! exocytic process intersection_of: GO:0001821 ! histamine secretion intersection_of: RO:0002608 CL:0000233 ! process has causal agent platelet relationship: BFO:0000050 GO:0002576 ! part of platelet degranulation relationship: RO:0002608 CL:0000233 ! process has causal agent platelet [Term] id: GO:0002556 name: serotonin secretion by basophil namespace: biological_process def: "The regulated release of serotonin by a basophil or group of basophils." [GOC:add, ISBN:0781735149] synonym: "serotonin release by basophil" RELATED [GOC:tb] is_a: GO:0002442 ! serotonin secretion involved in inflammatory response is_a: GO:0051649 ! establishment of localization in cell is_a: GO:0140029 ! exocytic process intersection_of: GO:0001820 ! serotonin secretion intersection_of: RO:0002608 CL:0000767 ! process has causal agent basophil relationship: BFO:0000050 GO:0002561 ! part of basophil degranulation relationship: RO:0002608 CL:0000767 ! process has causal agent basophil [Term] id: GO:0002557 name: histamine secretion by basophil namespace: biological_process def: "The regulated release of histamine by a basophil or group of basophils." [GOC:add, ISBN:0781735149] is_a: GO:0002441 ! histamine secretion involved in inflammatory response is_a: GO:0051649 ! establishment of localization in cell is_a: GO:0140029 ! exocytic process intersection_of: GO:0001821 ! histamine secretion intersection_of: RO:0002608 CL:0000767 ! process has causal agent basophil relationship: BFO:0000050 GO:0002561 ! part of basophil degranulation relationship: RO:0002608 CL:0000767 ! process has causal agent basophil [Term] id: GO:0002560 name: basophil mediated immunity namespace: biological_process def: "Any process involved in the carrying out of an immune response by a basophil." [GOC:add, ISBN:0781735149] is_a: GO:0002444 ! myeloid leukocyte mediated immunity intersection_of: GO:0002376 ! immune system process intersection_of: RO:0002608 CL:0000767 ! process has causal agent basophil relationship: RO:0002608 CL:0000767 ! process has causal agent basophil [Term] id: GO:0002561 name: basophil degranulation namespace: biological_process def: "The regulated exocytosis of secretory granules containing preformed mediators such as histamine, serotonin, and neutral proteases by a basophil." [GOC:add, ISBN:0781735149] is_a: GO:0043299 ! leukocyte degranulation intersection_of: GO:0045055 ! regulated exocytosis intersection_of: BFO:0000066 CL:0000767 ! occurs in basophil relationship: BFO:0000050 GO:0002276 ! part of basophil activation involved in immune response relationship: BFO:0000050 GO:0002560 ! part of basophil mediated immunity relationship: BFO:0000066 CL:0000767 ! occurs in basophil [Term] id: GO:0002562 name: somatic diversification of immune receptors via germline recombination within a single locus namespace: biological_process def: "The process in which immune receptor genes are diversified through recombination of the germline genetic elements within a single genetic locus." [GOC:add, ISBN:0781735149, PMID:16102575, PMID:16166509] is_a: GO:0002200 ! somatic diversification of immune receptors is_a: GO:0016444 ! somatic cell DNA recombination property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4751 [Term] id: GO:0002566 name: somatic diversification of immune receptors via somatic mutation namespace: biological_process def: "The process in which immune receptor genes are diversified through somatic mutation." [ISBN:0781735149, PMID:16102575] is_a: GO:0002200 ! somatic diversification of immune receptors property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4895 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0002572 name: pro-T cell differentiation namespace: biological_process def: "The process in which a precursor cell type acquires the specialized features of a pro-T cell. Pro-T cells are the earliest stage of the T cell lineage but are not fully committed." [GOC:add, ISBN:0781735149] synonym: "pro-T lymphocyte differentiation" EXACT [] is_a: GO:0002320 ! lymphoid progenitor cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000827 ! results in acquisition of features of pro-T cell relationship: BFO:0000050 GO:0030217 ! part of T cell differentiation relationship: RO:0002315 CL:0000827 ! results in acquisition of features of pro-T cell [Term] id: GO:0002573 name: myeloid leukocyte differentiation namespace: biological_process def: "The process in which a relatively unspecialized myeloid precursor cell acquires the specialized features of any cell of the myeloid leukocyte lineage." [GOC:add, PMID:16551251] synonym: "myeloid leucocyte differentiation" EXACT [] is_a: GO:0002521 ! leukocyte differentiation is_a: GO:0030099 ! myeloid cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000766 ! results in acquisition of features of myeloid leukocyte relationship: RO:0002315 CL:0000766 ! results in acquisition of features of myeloid leukocyte [Term] id: GO:0002574 name: thrombocyte differentiation namespace: biological_process def: "The process in which a relatively unspecialized myeloid precursor cell acquires the specialized features of a thrombocyte, a nucleated cell found in all vertebrates but mammals involved in hemostasis." [GOC:add] comment: Note that platelets are the non-nucleated mammalian functional equivalent of the nucleated thrombocytes of non-mammalian vertebrates and are sometimes also referred to as thrombocytes. Platelet formation in mammals is covered by the biological_process term platelet formation ; GO:0030220. is_a: GO:0030099 ! myeloid cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000762 ! results in acquisition of features of nucleated thrombocyte relationship: RO:0002315 CL:0000762 ! results in acquisition of features of nucleated thrombocyte [Term] id: GO:0002575 name: basophil chemotaxis namespace: biological_process def: "The movement of a basophil in response to an external stimulus." [GOC:add, PMID:11292027] is_a: GO:0071621 ! granulocyte chemotaxis intersection_of: GO:0006935 ! chemotaxis intersection_of: RO:0002565 CL:0000767 ! results in movement of basophil relationship: RO:0002565 CL:0000767 ! results in movement of basophil [Term] id: GO:0002576 name: platelet degranulation namespace: biological_process def: "The regulated exocytosis of secretory granules containing preformed mediators such as histamine and serotonin by a platelet." [GOC:add] synonym: "platelet exocytosis" EXACT [] xref: Reactome:R-HSA-114608 "Platelet degranulation" is_a: GO:0045055 ! regulated exocytosis is_a: GO:0051649 ! establishment of localization in cell intersection_of: GO:0045055 ! regulated exocytosis intersection_of: BFO:0000066 CL:0000233 ! occurs in platelet relationship: BFO:0000066 CL:0000233 ! occurs in platelet [Term] id: GO:0002577 name: regulation of antigen processing and presentation namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of antigen processing and presentation." [GOC:add] is_a: GO:0002682 ! regulation of immune system process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0019882 ! regulates antigen processing and presentation relationship: RO:0002211 GO:0019882 ! regulates antigen processing and presentation property_value: RO:0002161 NCBITaxon:4895 [Term] id: GO:0002578 name: negative regulation of antigen processing and presentation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of antigen processing and presentation." [GOC:add] synonym: "down regulation of antigen processing and presentation" EXACT [] synonym: "down-regulation of antigen processing and presentation" EXACT [] synonym: "downregulation of antigen processing and presentation" EXACT [] synonym: "inhibition of antigen processing and presentation" NARROW [] is_a: GO:0002577 ! regulation of antigen processing and presentation is_a: GO:0002683 ! negative regulation of immune system process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0019882 ! negatively regulates antigen processing and presentation relationship: RO:0002212 GO:0019882 ! negatively regulates antigen processing and presentation property_value: RO:0002161 NCBITaxon:4895 [Term] id: GO:0002579 name: positive regulation of antigen processing and presentation namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of antigen processing and presentation." [GOC:add] synonym: "activation of antigen processing and presentation" NARROW [] synonym: "stimulation of antigen processing and presentation" NARROW [] synonym: "up regulation of antigen processing and presentation" EXACT [] synonym: "up-regulation of antigen processing and presentation" EXACT [] synonym: "upregulation of antigen processing and presentation" EXACT [] is_a: GO:0002577 ! regulation of antigen processing and presentation is_a: GO:0002684 ! positive regulation of immune system process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0019882 ! positively regulates antigen processing and presentation relationship: RO:0002213 GO:0019882 ! positively regulates antigen processing and presentation property_value: RO:0002161 NCBITaxon:4895 [Term] id: GO:0002580 name: regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of antigen processing and presentation of antigen (peptide or polysaccharide) via MHC class II." [GOC:add] synonym: "regulation of peptide or polysaccharide antigen processing and presentation via MHC class II" EXACT [] is_a: GO:0002577 ! regulation of antigen processing and presentation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0002504 ! regulates antigen processing and presentation of peptide or polysaccharide antigen via MHC class II relationship: RO:0002211 GO:0002504 ! regulates antigen processing and presentation of peptide or polysaccharide antigen via MHC class II property_value: RO:0002161 NCBITaxon:4895 [Term] id: GO:0002581 name: negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of antigen processing and presentation of antigen (peptide or polysaccharide) via MHC class II." [GOC:add] synonym: "down regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II" EXACT [] synonym: "down-regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II" EXACT [] synonym: "downregulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II" EXACT [] synonym: "inhibition of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II" NARROW [] synonym: "negative regulation of peptide or polysaccharide antigen processing and presentation via MHC class II" EXACT [] is_a: GO:0002578 ! negative regulation of antigen processing and presentation is_a: GO:0002580 ! regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0002504 ! negatively regulates antigen processing and presentation of peptide or polysaccharide antigen via MHC class II relationship: RO:0002212 GO:0002504 ! negatively regulates antigen processing and presentation of peptide or polysaccharide antigen via MHC class II property_value: RO:0002161 NCBITaxon:4895 [Term] id: GO:0002582 name: positive regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of antigen processing and presentation of antigen (peptide or polysaccharide) via MHC class II." [GOC:add] synonym: "activation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II" NARROW [] synonym: "positive regulation of peptide or polysaccharide antigen processing and presentation via MHC class II" EXACT [] synonym: "stimulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II" NARROW [] synonym: "up regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II" EXACT [] synonym: "up-regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II" EXACT [] synonym: "upregulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II" EXACT [] is_a: GO:0002579 ! positive regulation of antigen processing and presentation is_a: GO:0002580 ! regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0002504 ! positively regulates antigen processing and presentation of peptide or polysaccharide antigen via MHC class II relationship: RO:0002213 GO:0002504 ! positively regulates antigen processing and presentation of peptide or polysaccharide antigen via MHC class II property_value: RO:0002161 NCBITaxon:4895 [Term] id: GO:0002583 name: regulation of antigen processing and presentation of peptide antigen namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of antigen processing and presentation of peptide antigen." [GOC:add] synonym: "regulation of peptide antigen processing and presentation" EXACT [] is_a: GO:0002577 ! regulation of antigen processing and presentation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0048002 ! regulates antigen processing and presentation of peptide antigen relationship: RO:0002211 GO:0048002 ! regulates antigen processing and presentation of peptide antigen property_value: RO:0002161 NCBITaxon:4895 [Term] id: GO:0002584 name: negative regulation of antigen processing and presentation of peptide antigen namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of antigen processing and presentation of peptide antigen." [GOC:add] synonym: "down regulation of antigen processing and presentation of peptide antigen" EXACT [] synonym: "down-regulation of antigen processing and presentation of peptide antigen" EXACT [] synonym: "downregulation of antigen processing and presentation of peptide antigen" EXACT [] synonym: "inhibition of antigen processing and presentation of peptide antigen" NARROW [] synonym: "negative regulation of peptide antigen processing and presentation" EXACT [] is_a: GO:0002578 ! negative regulation of antigen processing and presentation is_a: GO:0002583 ! regulation of antigen processing and presentation of peptide antigen intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0048002 ! negatively regulates antigen processing and presentation of peptide antigen relationship: RO:0002212 GO:0048002 ! negatively regulates antigen processing and presentation of peptide antigen property_value: RO:0002161 NCBITaxon:4895 [Term] id: GO:0002585 name: positive regulation of antigen processing and presentation of peptide antigen namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of antigen processing and presentation of peptide antigen." [GOC:add] synonym: "activation of antigen processing and presentation of peptide antigen" NARROW [] synonym: "positive regulation of peptide antigen processing and presentation" EXACT [] synonym: "stimulation of antigen processing and presentation of peptide antigen" NARROW [] synonym: "up regulation of antigen processing and presentation of peptide antigen" EXACT [] synonym: "up-regulation of antigen processing and presentation of peptide antigen" EXACT [] synonym: "upregulation of antigen processing and presentation of peptide antigen" EXACT [] is_a: GO:0002579 ! positive regulation of antigen processing and presentation is_a: GO:0002583 ! regulation of antigen processing and presentation of peptide antigen intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0048002 ! positively regulates antigen processing and presentation of peptide antigen relationship: RO:0002213 GO:0048002 ! positively regulates antigen processing and presentation of peptide antigen property_value: RO:0002161 NCBITaxon:4895 [Term] id: GO:0002586 name: regulation of antigen processing and presentation of peptide antigen via MHC class II namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of antigen processing and presentation of peptide antigen via MHC class II." [GOC:add] synonym: "regulation of peptide antigen processing and presentation via MHC class II" EXACT [] is_a: GO:0002580 ! regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II is_a: GO:0002583 ! regulation of antigen processing and presentation of peptide antigen intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0002495 ! regulates antigen processing and presentation of peptide antigen via MHC class II relationship: RO:0002211 GO:0002495 ! regulates antigen processing and presentation of peptide antigen via MHC class II property_value: RO:0002161 NCBITaxon:4895 [Term] id: GO:0002587 name: negative regulation of antigen processing and presentation of peptide antigen via MHC class II namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of antigen processing and presentation of peptide antigen via MHC class II." [GOC:add] synonym: "down regulation of antigen processing and presentation of peptide antigen via MHC class II" EXACT [] synonym: "down-regulation of antigen processing and presentation of peptide antigen via MHC class II" EXACT [] synonym: "downregulation of antigen processing and presentation of peptide antigen via MHC class II" EXACT [] synonym: "inhibition of antigen processing and presentation of peptide antigen via MHC class II" NARROW [] synonym: "negative regulation of peptide antigen processing and presentation via MHC class II" EXACT [] is_a: GO:0002581 ! negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II is_a: GO:0002584 ! negative regulation of antigen processing and presentation of peptide antigen is_a: GO:0002586 ! regulation of antigen processing and presentation of peptide antigen via MHC class II intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0002495 ! negatively regulates antigen processing and presentation of peptide antigen via MHC class II relationship: RO:0002212 GO:0002495 ! negatively regulates antigen processing and presentation of peptide antigen via MHC class II property_value: RO:0002161 NCBITaxon:4895 [Term] id: GO:0002588 name: positive regulation of antigen processing and presentation of peptide antigen via MHC class II namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of antigen processing and presentation of peptide antigen via MHC class II." [GOC:add] synonym: "activation of antigen processing and presentation of peptide antigen via MHC class II" NARROW [] synonym: "positive regulation of peptide antigen processing and presentation via MHC class II" EXACT [] synonym: "stimulation of antigen processing and presentation of peptide antigen via MHC class II" NARROW [] synonym: "up regulation of antigen processing and presentation of peptide antigen via MHC class II" EXACT [] synonym: "up-regulation of antigen processing and presentation of peptide antigen via MHC class II" EXACT [] synonym: "upregulation of antigen processing and presentation of peptide antigen via MHC class II" EXACT [] is_a: GO:0002582 ! positive regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II is_a: GO:0002585 ! positive regulation of antigen processing and presentation of peptide antigen is_a: GO:0002586 ! regulation of antigen processing and presentation of peptide antigen via MHC class II intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0002495 ! positively regulates antigen processing and presentation of peptide antigen via MHC class II relationship: RO:0002213 GO:0002495 ! positively regulates antigen processing and presentation of peptide antigen via MHC class II property_value: RO:0002161 NCBITaxon:4895 [Term] id: GO:0002589 name: regulation of antigen processing and presentation of peptide antigen via MHC class I namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of antigen processing and presentation of peptide antigen via MHC class I." [GOC:add] synonym: "regulation of peptide antigen processing and presentation via MHC class I" EXACT [] is_a: GO:0002583 ! regulation of antigen processing and presentation of peptide antigen intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0002474 ! regulates antigen processing and presentation of peptide antigen via MHC class I relationship: RO:0002211 GO:0002474 ! regulates antigen processing and presentation of peptide antigen via MHC class I property_value: RO:0002161 NCBITaxon:4895 [Term] id: GO:0002590 name: negative regulation of antigen processing and presentation of peptide antigen via MHC class I namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of antigen processing and presentation of peptide antigen via MHC class I." [GOC:add] synonym: "down regulation of antigen processing and presentation of peptide antigen via MHC class I" EXACT [] synonym: "down-regulation of antigen processing and presentation of peptide antigen via MHC class I" EXACT [] synonym: "downregulation of antigen processing and presentation of peptide antigen via MHC class I" EXACT [] synonym: "inhibition of antigen processing and presentation of peptide antigen via MHC class I" NARROW [] synonym: "negative regulation of peptide antigen processing and presentation via MHC class I" EXACT [] is_a: GO:0002584 ! negative regulation of antigen processing and presentation of peptide antigen is_a: GO:0002589 ! regulation of antigen processing and presentation of peptide antigen via MHC class I intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0002474 ! negatively regulates antigen processing and presentation of peptide antigen via MHC class I relationship: RO:0002212 GO:0002474 ! negatively regulates antigen processing and presentation of peptide antigen via MHC class I property_value: RO:0002161 NCBITaxon:4895 [Term] id: GO:0002591 name: positive regulation of antigen processing and presentation of peptide antigen via MHC class I namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of antigen processing and presentation of peptide antigen via MHC class I." [GOC:add] synonym: "activation of antigen processing and presentation of peptide antigen via MHC class I" NARROW [] synonym: "positive regulation of peptide antigen processing and presentation via MHC class I" EXACT [] synonym: "stimulation of antigen processing and presentation of peptide antigen via MHC class I" NARROW [] synonym: "up regulation of antigen processing and presentation of peptide antigen via MHC class I" EXACT [] synonym: "up-regulation of antigen processing and presentation of peptide antigen via MHC class I" EXACT [] synonym: "upregulation of antigen processing and presentation of peptide antigen via MHC class I" EXACT [] is_a: GO:0002585 ! positive regulation of antigen processing and presentation of peptide antigen is_a: GO:0002589 ! regulation of antigen processing and presentation of peptide antigen via MHC class I intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0002474 ! positively regulates antigen processing and presentation of peptide antigen via MHC class I relationship: RO:0002213 GO:0002474 ! positively regulates antigen processing and presentation of peptide antigen via MHC class I property_value: RO:0002161 NCBITaxon:4895 [Term] id: GO:0002604 name: regulation of dendritic cell antigen processing and presentation namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of dendritic cell antigen processing and presentation." [GOC:add] is_a: GO:0002577 ! regulation of antigen processing and presentation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0002468 ! regulates dendritic cell antigen processing and presentation relationship: RO:0002211 GO:0002468 ! regulates dendritic cell antigen processing and presentation property_value: RO:0002161 NCBITaxon:4895 [Term] id: GO:0002605 name: negative regulation of dendritic cell antigen processing and presentation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of dendritic cell antigen processing and presentation." [GOC:add] synonym: "down regulation of dendritic cell antigen processing and presentation" EXACT [] synonym: "down-regulation of dendritic cell antigen processing and presentation" EXACT [] synonym: "downregulation of dendritic cell antigen processing and presentation" EXACT [] synonym: "inhibition of dendritic cell antigen processing and presentation" NARROW [] is_a: GO:0002578 ! negative regulation of antigen processing and presentation is_a: GO:0002604 ! regulation of dendritic cell antigen processing and presentation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0002468 ! negatively regulates dendritic cell antigen processing and presentation relationship: RO:0002212 GO:0002468 ! negatively regulates dendritic cell antigen processing and presentation property_value: RO:0002161 NCBITaxon:4895 [Term] id: GO:0002606 name: positive regulation of dendritic cell antigen processing and presentation namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of dendritic cell antigen processing and presentation." [GOC:add] synonym: "activation of dendritic cell antigen processing and presentation" NARROW [] synonym: "stimulation of dendritic cell antigen processing and presentation" NARROW [] synonym: "up regulation of dendritic cell antigen processing and presentation" EXACT [] synonym: "up-regulation of dendritic cell antigen processing and presentation" EXACT [] synonym: "upregulation of dendritic cell antigen processing and presentation" EXACT [] is_a: GO:0002579 ! positive regulation of antigen processing and presentation is_a: GO:0002604 ! regulation of dendritic cell antigen processing and presentation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0002468 ! positively regulates dendritic cell antigen processing and presentation relationship: RO:0002213 GO:0002468 ! positively regulates dendritic cell antigen processing and presentation property_value: RO:0002161 NCBITaxon:4895 [Term] id: GO:0002607 name: regulation of myeloid dendritic cell antigen processing and presentation namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of myeloid dendritic cell antigen processing and presentation." [GOC:add] is_a: GO:0002604 ! regulation of dendritic cell antigen processing and presentation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0002469 ! regulates myeloid dendritic cell antigen processing and presentation relationship: RO:0002211 GO:0002469 ! regulates myeloid dendritic cell antigen processing and presentation property_value: RO:0002161 NCBITaxon:4895 [Term] id: GO:0002608 name: negative regulation of myeloid dendritic cell antigen processing and presentation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of myeloid dendritic cell antigen processing and presentation." [GOC:add] synonym: "down regulation of myeloid dendritic cell antigen processing and presentation" EXACT [] synonym: "down-regulation of myeloid dendritic cell antigen processing and presentation" EXACT [] synonym: "downregulation of myeloid dendritic cell antigen processing and presentation" EXACT [] synonym: "inhibition of myeloid dendritic cell antigen processing and presentation" NARROW [] is_a: GO:0002605 ! negative regulation of dendritic cell antigen processing and presentation is_a: GO:0002607 ! regulation of myeloid dendritic cell antigen processing and presentation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0002469 ! negatively regulates myeloid dendritic cell antigen processing and presentation relationship: RO:0002212 GO:0002469 ! negatively regulates myeloid dendritic cell antigen processing and presentation property_value: RO:0002161 NCBITaxon:4895 [Term] id: GO:0002609 name: positive regulation of myeloid dendritic cell antigen processing and presentation namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of myeloid dendritic cell antigen processing and presentation." [GOC:add] synonym: "activation of myeloid dendritic cell antigen processing and presentation" NARROW [] synonym: "stimulation of myeloid dendritic cell antigen processing and presentation" NARROW [] synonym: "up regulation of myeloid dendritic cell antigen processing and presentation" EXACT [] synonym: "up-regulation of myeloid dendritic cell antigen processing and presentation" EXACT [] synonym: "upregulation of myeloid dendritic cell antigen processing and presentation" EXACT [] is_a: GO:0002606 ! positive regulation of dendritic cell antigen processing and presentation is_a: GO:0002607 ! regulation of myeloid dendritic cell antigen processing and presentation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0002469 ! positively regulates myeloid dendritic cell antigen processing and presentation relationship: RO:0002213 GO:0002469 ! positively regulates myeloid dendritic cell antigen processing and presentation property_value: RO:0002161 NCBITaxon:4895 [Term] id: GO:0002610 name: regulation of plasmacytoid dendritic cell antigen processing and presentation namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of plasmacytoid dendritic cell antigen processing and presentation." [GOC:add] is_a: GO:0002604 ! regulation of dendritic cell antigen processing and presentation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0002470 ! regulates plasmacytoid dendritic cell antigen processing and presentation relationship: RO:0002211 GO:0002470 ! regulates plasmacytoid dendritic cell antigen processing and presentation property_value: RO:0002161 NCBITaxon:4895 [Term] id: GO:0002611 name: negative regulation of plasmacytoid dendritic cell antigen processing and presentation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of plasmacytoid dendritic cell antigen processing and presentation." [GOC:add] synonym: "down regulation of plasmacytoid dendritic cell antigen processing and presentation" EXACT [] synonym: "down-regulation of plasmacytoid dendritic cell antigen processing and presentation" EXACT [] synonym: "downregulation of plasmacytoid dendritic cell antigen processing and presentation" EXACT [] synonym: "inhibition of plasmacytoid dendritic cell antigen processing and presentation" NARROW [] is_a: GO:0002605 ! negative regulation of dendritic cell antigen processing and presentation is_a: GO:0002610 ! regulation of plasmacytoid dendritic cell antigen processing and presentation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0002470 ! negatively regulates plasmacytoid dendritic cell antigen processing and presentation relationship: RO:0002212 GO:0002470 ! negatively regulates plasmacytoid dendritic cell antigen processing and presentation property_value: RO:0002161 NCBITaxon:4895 [Term] id: GO:0002612 name: positive regulation of plasmacytoid dendritic cell antigen processing and presentation namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of plasmacytoid dendritic cell antigen processing and presentation." [GOC:add] synonym: "activation of plasmacytoid dendritic cell antigen processing and presentation" NARROW [] synonym: "stimulation of plasmacytoid dendritic cell antigen processing and presentation" NARROW [] synonym: "up regulation of plasmacytoid dendritic cell antigen processing and presentation" EXACT [] synonym: "up-regulation of plasmacytoid dendritic cell antigen processing and presentation" EXACT [] synonym: "upregulation of plasmacytoid dendritic cell antigen processing and presentation" EXACT [] is_a: GO:0002606 ! positive regulation of dendritic cell antigen processing and presentation is_a: GO:0002610 ! regulation of plasmacytoid dendritic cell antigen processing and presentation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0002470 ! positively regulates plasmacytoid dendritic cell antigen processing and presentation relationship: RO:0002213 GO:0002470 ! positively regulates plasmacytoid dendritic cell antigen processing and presentation property_value: RO:0002161 NCBITaxon:4895 [Term] id: GO:0002613 name: regulation of monocyte antigen processing and presentation namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of monocyte antigen processing and presentation." [GOC:add] is_a: GO:0002577 ! regulation of antigen processing and presentation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0002471 ! regulates monocyte antigen processing and presentation relationship: RO:0002211 GO:0002471 ! regulates monocyte antigen processing and presentation property_value: RO:0002161 NCBITaxon:4895 [Term] id: GO:0002614 name: negative regulation of monocyte antigen processing and presentation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of monocyte antigen processing and presentation." [GOC:add] synonym: "down regulation of monocyte antigen processing and presentation" EXACT [] synonym: "down-regulation of monocyte antigen processing and presentation" EXACT [] synonym: "downregulation of monocyte antigen processing and presentation" EXACT [] synonym: "inhibition of monocyte antigen processing and presentation" NARROW [] is_a: GO:0002578 ! negative regulation of antigen processing and presentation is_a: GO:0002613 ! regulation of monocyte antigen processing and presentation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0002471 ! negatively regulates monocyte antigen processing and presentation relationship: RO:0002212 GO:0002471 ! negatively regulates monocyte antigen processing and presentation property_value: RO:0002161 NCBITaxon:4895 [Term] id: GO:0002615 name: positive regulation of monocyte antigen processing and presentation namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of monocyte antigen processing and presentation." [GOC:add] synonym: "activation of monocyte antigen processing and presentation" NARROW [] synonym: "stimulation of monocyte antigen processing and presentation" NARROW [] synonym: "up regulation of monocyte antigen processing and presentation" EXACT [] synonym: "up-regulation of monocyte antigen processing and presentation" EXACT [] synonym: "upregulation of monocyte antigen processing and presentation" EXACT [] is_a: GO:0002579 ! positive regulation of antigen processing and presentation is_a: GO:0002613 ! regulation of monocyte antigen processing and presentation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0002471 ! positively regulates monocyte antigen processing and presentation relationship: RO:0002213 GO:0002471 ! positively regulates monocyte antigen processing and presentation property_value: RO:0002161 NCBITaxon:4895 [Term] id: GO:0002616 name: regulation of macrophage antigen processing and presentation namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of macrophage antigen processing and presentation." [GOC:add] is_a: GO:0002577 ! regulation of antigen processing and presentation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0002472 ! regulates macrophage antigen processing and presentation relationship: RO:0002211 GO:0002472 ! regulates macrophage antigen processing and presentation property_value: RO:0002161 NCBITaxon:4895 [Term] id: GO:0002617 name: negative regulation of macrophage antigen processing and presentation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of macrophage antigen processing and presentation." [GOC:add] synonym: "down regulation of macrophage antigen processing and presentation" EXACT [] synonym: "down-regulation of macrophage antigen processing and presentation" EXACT [] synonym: "downregulation of macrophage antigen processing and presentation" EXACT [] synonym: "inhibition of macrophage antigen processing and presentation" NARROW [] is_a: GO:0002578 ! negative regulation of antigen processing and presentation is_a: GO:0002616 ! regulation of macrophage antigen processing and presentation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0002472 ! negatively regulates macrophage antigen processing and presentation relationship: RO:0002212 GO:0002472 ! negatively regulates macrophage antigen processing and presentation property_value: RO:0002161 NCBITaxon:4895 [Term] id: GO:0002618 name: positive regulation of macrophage antigen processing and presentation namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of macrophage antigen processing and presentation." [GOC:add] synonym: "activation of macrophage antigen processing and presentation" NARROW [] synonym: "stimulation of macrophage antigen processing and presentation" NARROW [] synonym: "up regulation of macrophage antigen processing and presentation" EXACT [] synonym: "up-regulation of macrophage antigen processing and presentation" EXACT [] synonym: "upregulation of macrophage antigen processing and presentation" EXACT [] is_a: GO:0002579 ! positive regulation of antigen processing and presentation is_a: GO:0002616 ! regulation of macrophage antigen processing and presentation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0002472 ! positively regulates macrophage antigen processing and presentation relationship: RO:0002213 GO:0002472 ! positively regulates macrophage antigen processing and presentation property_value: RO:0002161 NCBITaxon:4895 [Term] id: GO:0002622 name: regulation of B cell antigen processing and presentation namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of B cell antigen processing and presentation." [GOC:add] synonym: "regulation of B lymphocyte antigen processing and presentation" EXACT [] synonym: "regulation of B-cell antigen processing and presentation" EXACT [] synonym: "regulation of B-lymphocyte antigen processing and presentation" EXACT [] is_a: GO:0002577 ! regulation of antigen processing and presentation is_a: GO:0002712 ! regulation of B cell mediated immunity intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0002450 ! regulates B cell antigen processing and presentation relationship: RO:0002211 GO:0002450 ! regulates B cell antigen processing and presentation [Term] id: GO:0002623 name: negative regulation of B cell antigen processing and presentation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of B cell antigen processing and presentation." [GOC:add] synonym: "down regulation of B cell antigen processing and presentation" EXACT [] synonym: "down-regulation of B cell antigen processing and presentation" EXACT [] synonym: "downregulation of B cell antigen processing and presentation" EXACT [] synonym: "inhibition of B cell antigen processing and presentation" NARROW [] synonym: "negative regulation of B lymphocyte antigen processing and presentation" EXACT [] synonym: "negative regulation of B-cell antigen processing and presentation" EXACT [] synonym: "negative regulation of B-lymphocyte antigen processing and presentation" EXACT [] is_a: GO:0002578 ! negative regulation of antigen processing and presentation is_a: GO:0002622 ! regulation of B cell antigen processing and presentation is_a: GO:0002713 ! negative regulation of B cell mediated immunity intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0002450 ! negatively regulates B cell antigen processing and presentation relationship: RO:0002212 GO:0002450 ! negatively regulates B cell antigen processing and presentation [Term] id: GO:0002624 name: positive regulation of B cell antigen processing and presentation namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of B cell antigen processing and presentation." [GOC:add] synonym: "activation of B cell antigen processing and presentation" NARROW [] synonym: "positive regulation of B lymphocyte antigen processing and presentation" EXACT [] synonym: "positive regulation of B-cell antigen processing and presentation" EXACT [] synonym: "positive regulation of B-lymphocyte antigen processing and presentation" EXACT [] synonym: "stimulation of B cell antigen processing and presentation" NARROW [] synonym: "up regulation of B cell antigen processing and presentation" EXACT [] synonym: "up-regulation of B cell antigen processing and presentation" EXACT [] synonym: "upregulation of B cell antigen processing and presentation" EXACT [] is_a: GO:0002579 ! positive regulation of antigen processing and presentation is_a: GO:0002622 ! regulation of B cell antigen processing and presentation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0002450 ! positively regulates B cell antigen processing and presentation relationship: RO:0002213 GO:0002450 ! positively regulates B cell antigen processing and presentation [Term] id: GO:0002625 name: regulation of T cell antigen processing and presentation namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of T cell antigen processing and presentation." [GOC:add] synonym: "regulation of T lymphocyte antigen processing and presentation" EXACT [] synonym: "regulation of T-cell antigen processing and presentation" EXACT [] synonym: "regulation of T-lymphocyte antigen processing and presentation" EXACT [] is_a: GO:0002577 ! regulation of antigen processing and presentation is_a: GO:0002709 ! regulation of T cell mediated immunity intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0002457 ! regulates T cell antigen processing and presentation relationship: RO:0002211 GO:0002457 ! regulates T cell antigen processing and presentation [Term] id: GO:0002626 name: negative regulation of T cell antigen processing and presentation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of T cell antigen processing and presentation." [GOC:add] synonym: "down regulation of T cell antigen processing and presentation" EXACT [] synonym: "down-regulation of T cell antigen processing and presentation" EXACT [] synonym: "downregulation of T cell antigen processing and presentation" EXACT [] synonym: "inhibition of T cell antigen processing and presentation" NARROW [] synonym: "negative regulation of T lymphocyte antigen processing and presentation" EXACT [] synonym: "negative regulation of T-cell antigen processing and presentation" EXACT [] synonym: "negative regulation of T-lymphocyte antigen processing and presentation" EXACT [] is_a: GO:0002578 ! negative regulation of antigen processing and presentation is_a: GO:0002625 ! regulation of T cell antigen processing and presentation is_a: GO:0002710 ! negative regulation of T cell mediated immunity intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0002457 ! negatively regulates T cell antigen processing and presentation relationship: RO:0002212 GO:0002457 ! negatively regulates T cell antigen processing and presentation [Term] id: GO:0002627 name: positive regulation of T cell antigen processing and presentation namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of T cell antigen processing and presentation." [GOC:add] synonym: "activation of T cell antigen processing and presentation" NARROW [] synonym: "positive regulation of T lymphocyte antigen processing and presentation" EXACT [] synonym: "positive regulation of T-cell antigen processing and presentation" EXACT [] synonym: "positive regulation of T-lymphocyte antigen processing and presentation" EXACT [] synonym: "stimulation of T cell antigen processing and presentation" NARROW [] synonym: "up regulation of T cell antigen processing and presentation" EXACT [] synonym: "up-regulation of T cell antigen processing and presentation" EXACT [] synonym: "upregulation of T cell antigen processing and presentation" EXACT [] is_a: GO:0002579 ! positive regulation of antigen processing and presentation is_a: GO:0002625 ! regulation of T cell antigen processing and presentation is_a: GO:0002711 ! positive regulation of T cell mediated immunity intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0002457 ! positively regulates T cell antigen processing and presentation relationship: RO:0002213 GO:0002457 ! positively regulates T cell antigen processing and presentation [Term] id: GO:0002628 name: regulation of proteolysis associated with antigen processing and presentation namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of proteolysis associated with antigen processing and presentation." [GOC:add] is_a: GO:1903050 ! regulation of proteolysis involved in protein catabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0002496 ! regulates proteolysis associated with antigen processing and presentation relationship: RO:0002211 GO:0002496 ! regulates proteolysis associated with antigen processing and presentation property_value: RO:0002161 NCBITaxon:4895 [Term] id: GO:0002629 name: negative regulation of proteolysis associated with antigen processing and presentation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of proteolysis associated with antigen processing and presentation." [GOC:add] synonym: "down regulation of proteolysis associated with antigen processing and presentation" EXACT [] synonym: "down-regulation of proteolysis associated with antigen processing and presentation" EXACT [] synonym: "downregulation of proteolysis associated with antigen processing and presentation" EXACT [] synonym: "inhibition of proteolysis associated with antigen processing and presentation" NARROW [] is_a: GO:0002584 ! negative regulation of antigen processing and presentation of peptide antigen is_a: GO:0002628 ! regulation of proteolysis associated with antigen processing and presentation is_a: GO:0042177 ! negative regulation of protein catabolic process is_a: GO:1903051 ! negative regulation of proteolysis involved in protein catabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0002496 ! negatively regulates proteolysis associated with antigen processing and presentation relationship: RO:0002212 GO:0002496 ! negatively regulates proteolysis associated with antigen processing and presentation property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/29024" xsd:anyURI property_value: RO:0002161 NCBITaxon:4895 [Term] id: GO:0002630 name: positive regulation of proteolysis associated with antigen processing and presentation namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of proteolysis associated with antigen processing and presentation." [GOC:add] synonym: "activation of proteolysis associated with antigen processing and presentation" NARROW [] synonym: "stimulation of proteolysis associated with antigen processing and presentation" NARROW [] synonym: "up regulation of proteolysis associated with antigen processing and presentation" EXACT [] synonym: "up-regulation of proteolysis associated with antigen processing and presentation" EXACT [] synonym: "upregulation of proteolysis associated with antigen processing and presentation" EXACT [] is_a: GO:0002585 ! positive regulation of antigen processing and presentation of peptide antigen is_a: GO:0002628 ! regulation of proteolysis associated with antigen processing and presentation is_a: GO:0045732 ! positive regulation of protein catabolic process is_a: GO:1903052 ! positive regulation of proteolysis involved in protein catabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0002496 ! positively regulates proteolysis associated with antigen processing and presentation relationship: RO:0002213 GO:0002496 ! positively regulates proteolysis associated with antigen processing and presentation property_value: RO:0002161 NCBITaxon:4895 [Term] id: GO:0002631 name: regulation of granuloma formation namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of granuloma formation." [GOC:add] is_a: GO:0002676 ! regulation of chronic inflammatory response is_a: GO:0002697 ! regulation of immune effector process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0002432 ! regulates granuloma formation relationship: RO:0002211 GO:0002432 ! regulates granuloma formation [Term] id: GO:0002632 name: negative regulation of granuloma formation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of granuloma formation." [GOC:add] synonym: "down regulation of granuloma formation" EXACT [] synonym: "down-regulation of granuloma formation" EXACT [] synonym: "downregulation of granuloma formation" EXACT [] synonym: "inhibition of granuloma formation" NARROW [] is_a: GO:0002631 ! regulation of granuloma formation is_a: GO:0002677 ! negative regulation of chronic inflammatory response is_a: GO:0002698 ! negative regulation of immune effector process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0002432 ! negatively regulates granuloma formation relationship: RO:0002212 GO:0002432 ! negatively regulates granuloma formation [Term] id: GO:0002633 name: positive regulation of granuloma formation namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of granuloma formation." [GOC:add] synonym: "activation of granuloma formation" NARROW [] synonym: "stimulation of granuloma formation" NARROW [] synonym: "up regulation of granuloma formation" EXACT [] synonym: "up-regulation of granuloma formation" EXACT [] synonym: "upregulation of granuloma formation" EXACT [] is_a: GO:0002631 ! regulation of granuloma formation is_a: GO:0002678 ! positive regulation of chronic inflammatory response is_a: GO:0002699 ! positive regulation of immune effector process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0002432 ! positively regulates granuloma formation relationship: RO:0002213 GO:0002432 ! positively regulates granuloma formation [Term] id: GO:0002634 name: regulation of germinal center formation namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of germinal center formation." [GOC:add] is_a: GO:0002822 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains is_a: GO:0022603 ! regulation of anatomical structure morphogenesis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0002467 ! regulates germinal center formation relationship: RO:0002211 GO:0002467 ! regulates germinal center formation [Term] id: GO:0002635 name: negative regulation of germinal center formation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of germinal center formation." [GOC:add] synonym: "down regulation of germinal center formation" EXACT [] synonym: "down-regulation of germinal center formation" EXACT [] synonym: "downregulation of germinal center formation" EXACT [] synonym: "inhibition of germinal center formation" NARROW [] is_a: GO:0002634 ! regulation of germinal center formation is_a: GO:0002823 ! negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains is_a: GO:0051093 ! negative regulation of developmental process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0002467 ! negatively regulates germinal center formation relationship: RO:0002212 GO:0002467 ! negatively regulates germinal center formation [Term] id: GO:0002636 name: positive regulation of germinal center formation namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of germinal center formation." [GOC:add] synonym: "activation of germinal center formation" NARROW [] synonym: "stimulation of germinal center formation" NARROW [] synonym: "up regulation of germinal center formation" EXACT [] synonym: "up-regulation of germinal center formation" EXACT [] synonym: "upregulation of germinal center formation" EXACT [] is_a: GO:0002634 ! regulation of germinal center formation is_a: GO:0002824 ! positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains is_a: GO:0051094 ! positive regulation of developmental process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0002467 ! positively regulates germinal center formation relationship: RO:0002213 GO:0002467 ! positively regulates germinal center formation [Term] id: GO:0002637 name: regulation of immunoglobulin production namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of immunoglobulin production." [GOC:add] synonym: "regulation of antibody production" EXACT [] synonym: "regulation of immunoglobulin biosynthetic process" NARROW [] synonym: "regulation of immunoglobulin secretion" NARROW [] is_a: GO:0002700 ! regulation of production of molecular mediator of immune response intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0002377 ! regulates immunoglobulin production relationship: RO:0002211 GO:0002377 ! regulates immunoglobulin production property_value: RO:0002161 NCBITaxon:4895 [Term] id: GO:0002638 name: negative regulation of immunoglobulin production namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of immunoglobulin production." [GOC:add] synonym: "down regulation of immunoglobulin production" EXACT [] synonym: "down-regulation of immunoglobulin production" EXACT [] synonym: "downregulation of immunoglobulin production" EXACT [] synonym: "inhibition of immunoglobulin production" NARROW [] synonym: "negative regulation of immunoglobulin biosynthetic process" NARROW [] synonym: "negative regulation of immunoglobulin secretion" NARROW [] is_a: GO:0002637 ! regulation of immunoglobulin production is_a: GO:0002701 ! negative regulation of production of molecular mediator of immune response intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0002377 ! negatively regulates immunoglobulin production relationship: RO:0002212 GO:0002377 ! negatively regulates immunoglobulin production property_value: RO:0002161 NCBITaxon:4895 [Term] id: GO:0002639 name: positive regulation of immunoglobulin production namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of immunoglobulin production." [GOC:add] synonym: "activation of immunoglobulin production" NARROW [] synonym: "positive regulation of immunoglobulin biosynthetic process" NARROW [] synonym: "positive regulation of immunoglobulin secretion" NARROW [] synonym: "stimulation of immunoglobulin production" NARROW [] synonym: "up regulation of immunoglobulin production" EXACT [] synonym: "up-regulation of immunoglobulin production" EXACT [] synonym: "upregulation of immunoglobulin production" EXACT [] is_a: GO:0002637 ! regulation of immunoglobulin production is_a: GO:0002702 ! positive regulation of production of molecular mediator of immune response intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0002377 ! positively regulates immunoglobulin production relationship: RO:0002213 GO:0002377 ! positively regulates immunoglobulin production property_value: RO:0002161 NCBITaxon:4895 [Term] id: GO:0002643 name: regulation of tolerance induction namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of tolerance induction." [GOC:add] is_a: GO:0002682 ! regulation of immune system process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0002507 ! regulates tolerance induction relationship: RO:0002211 GO:0002507 ! regulates tolerance induction property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4895 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0002644 name: negative regulation of tolerance induction namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of tolerance induction." [GOC:add] synonym: "down regulation of tolerance induction" EXACT [] synonym: "down-regulation of tolerance induction" EXACT [] synonym: "downregulation of tolerance induction" EXACT [] synonym: "inhibition of tolerance induction" NARROW [] is_a: GO:0002643 ! regulation of tolerance induction is_a: GO:0002683 ! negative regulation of immune system process is_a: GO:0051093 ! negative regulation of developmental process is_a: GO:0051241 ! negative regulation of multicellular organismal process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0002507 ! negatively regulates tolerance induction relationship: RO:0002212 GO:0002507 ! negatively regulates tolerance induction property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4895 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0002645 name: positive regulation of tolerance induction namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of tolerance induction." [GOC:add] synonym: "activation of tolerance induction" NARROW [] synonym: "stimulation of tolerance induction" NARROW [] synonym: "up regulation of tolerance induction" EXACT [] synonym: "up-regulation of tolerance induction" EXACT [] synonym: "upregulation of tolerance induction" EXACT [] is_a: GO:0002643 ! regulation of tolerance induction is_a: GO:0002684 ! positive regulation of immune system process is_a: GO:0051240 ! positive regulation of multicellular organismal process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0002507 ! positively regulates tolerance induction relationship: RO:0002213 GO:0002507 ! positively regulates tolerance induction property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4895 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0002652 name: regulation of tolerance induction dependent upon immune response namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of tolerance induction dependent upon immune response." [GOC:add] synonym: "regulation of immune response-dependent tolerance induction" EXACT [] is_a: GO:0002643 ! regulation of tolerance induction is_a: GO:0002822 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0002461 ! regulates tolerance induction dependent upon immune response relationship: RO:0002211 GO:0002461 ! regulates tolerance induction dependent upon immune response [Term] id: GO:0002653 name: negative regulation of tolerance induction dependent upon immune response namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of tolerance induction dependent upon immune response." [GOC:add] synonym: "down regulation of tolerance induction dependent upon immune response" EXACT [] synonym: "down-regulation of tolerance induction dependent upon immune response" EXACT [] synonym: "downregulation of tolerance induction dependent upon immune response" EXACT [] synonym: "inhibition of tolerance induction dependent upon immune response" NARROW [] synonym: "negative regulation of immune response-dependent tolerance induction" EXACT [] is_a: GO:0002644 ! negative regulation of tolerance induction is_a: GO:0002652 ! regulation of tolerance induction dependent upon immune response is_a: GO:0002823 ! negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0002461 ! negatively regulates tolerance induction dependent upon immune response relationship: RO:0002212 GO:0002461 ! negatively regulates tolerance induction dependent upon immune response [Term] id: GO:0002654 name: positive regulation of tolerance induction dependent upon immune response namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of tolerance induction dependent upon immune response." [GOC:add] synonym: "activation of tolerance induction dependent upon immune response" NARROW [] synonym: "positive regulation of immune response-dependent tolerance induction" EXACT [] synonym: "stimulation of tolerance induction dependent upon immune response" NARROW [] synonym: "up regulation of tolerance induction dependent upon immune response" EXACT [] synonym: "up-regulation of tolerance induction dependent upon immune response" EXACT [] synonym: "upregulation of tolerance induction dependent upon immune response" EXACT [] is_a: GO:0002645 ! positive regulation of tolerance induction is_a: GO:0002652 ! regulation of tolerance induction dependent upon immune response is_a: GO:0002824 ! positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0002461 ! positively regulates tolerance induction dependent upon immune response relationship: RO:0002213 GO:0002461 ! positively regulates tolerance induction dependent upon immune response [Term] id: GO:0002655 name: regulation of tolerance induction to nonself antigen namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of tolerance induction to nonself antigen." [GOC:add] is_a: GO:0002652 ! regulation of tolerance induction dependent upon immune response intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0002462 ! regulates tolerance induction to nonself antigen relationship: RO:0002211 GO:0002462 ! regulates tolerance induction to nonself antigen [Term] id: GO:0002656 name: negative regulation of tolerance induction to nonself antigen namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of tolerance induction to nonself antigen." [GOC:add] synonym: "down regulation of tolerance induction to nonself antigen" EXACT [] synonym: "down-regulation of tolerance induction to nonself antigen" EXACT [] synonym: "downregulation of tolerance induction to nonself antigen" EXACT [] synonym: "inhibition of tolerance induction to nonself antigen" NARROW [] is_a: GO:0002653 ! negative regulation of tolerance induction dependent upon immune response is_a: GO:0002655 ! regulation of tolerance induction to nonself antigen intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0002462 ! negatively regulates tolerance induction to nonself antigen relationship: RO:0002212 GO:0002462 ! negatively regulates tolerance induction to nonself antigen [Term] id: GO:0002657 name: positive regulation of tolerance induction to nonself antigen namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of tolerance induction to nonself antigen." [GOC:add] synonym: "activation of tolerance induction to nonself antigen" NARROW [] synonym: "stimulation of tolerance induction to nonself antigen" NARROW [] synonym: "up regulation of tolerance induction to nonself antigen" EXACT [] synonym: "up-regulation of tolerance induction to nonself antigen" EXACT [] synonym: "upregulation of tolerance induction to nonself antigen" EXACT [] is_a: GO:0002654 ! positive regulation of tolerance induction dependent upon immune response is_a: GO:0002655 ! regulation of tolerance induction to nonself antigen intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0002462 ! positively regulates tolerance induction to nonself antigen relationship: RO:0002213 GO:0002462 ! positively regulates tolerance induction to nonself antigen [Term] id: GO:0002658 name: regulation of peripheral tolerance induction namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of peripheral tolerance induction." [GOC:add] is_a: GO:0002652 ! regulation of tolerance induction dependent upon immune response intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0002465 ! regulates peripheral tolerance induction relationship: RO:0002211 GO:0002465 ! regulates peripheral tolerance induction [Term] id: GO:0002659 name: negative regulation of peripheral tolerance induction namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of peripheral tolerance induction." [GOC:add] synonym: "down regulation of peripheral tolerance induction" EXACT [] synonym: "down-regulation of peripheral tolerance induction" EXACT [] synonym: "downregulation of peripheral tolerance induction" EXACT [] synonym: "inhibition of peripheral tolerance induction" NARROW [] is_a: GO:0002653 ! negative regulation of tolerance induction dependent upon immune response is_a: GO:0002658 ! regulation of peripheral tolerance induction intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0002465 ! negatively regulates peripheral tolerance induction relationship: RO:0002212 GO:0002465 ! negatively regulates peripheral tolerance induction [Term] id: GO:0002660 name: positive regulation of peripheral tolerance induction namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of peripheral tolerance induction." [GOC:add] synonym: "activation of peripheral tolerance induction" NARROW [] synonym: "stimulation of peripheral tolerance induction" NARROW [] synonym: "up regulation of peripheral tolerance induction" EXACT [] synonym: "up-regulation of peripheral tolerance induction" EXACT [] synonym: "upregulation of peripheral tolerance induction" EXACT [] is_a: GO:0002654 ! positive regulation of tolerance induction dependent upon immune response is_a: GO:0002658 ! regulation of peripheral tolerance induction intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0002465 ! positively regulates peripheral tolerance induction relationship: RO:0002213 GO:0002465 ! positively regulates peripheral tolerance induction [Term] id: GO:0002661 name: regulation of B cell tolerance induction namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of B cell tolerance induction." [GOC:add] synonym: "regulation of B lymphocyte tolerance induction" EXACT [] synonym: "regulation of B-cell tolerance induction" EXACT [] synonym: "regulation of B-lymphocyte tolerance induction" EXACT [] is_a: GO:0002643 ! regulation of tolerance induction intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0002514 ! regulates B cell tolerance induction relationship: RO:0002211 GO:0002514 ! regulates B cell tolerance induction property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4895 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0002662 name: negative regulation of B cell tolerance induction namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of B cell tolerance induction." [GOC:add] synonym: "down regulation of B cell tolerance induction" EXACT [] synonym: "down-regulation of B cell tolerance induction" EXACT [] synonym: "downregulation of B cell tolerance induction" EXACT [] synonym: "inhibition of B cell tolerance induction" NARROW [] synonym: "negative regulation of B lymphocyte tolerance induction" EXACT [] synonym: "negative regulation of B-cell tolerance induction" EXACT [] synonym: "negative regulation of B-lymphocyte tolerance induction" EXACT [] is_a: GO:0002644 ! negative regulation of tolerance induction is_a: GO:0002661 ! regulation of B cell tolerance induction intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0002514 ! negatively regulates B cell tolerance induction relationship: RO:0002212 GO:0002514 ! negatively regulates B cell tolerance induction property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4895 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0002663 name: positive regulation of B cell tolerance induction namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of B cell tolerance induction." [GOC:add] synonym: "activation of B cell tolerance induction" NARROW [] synonym: "positive regulation of B lymphocyte tolerance induction" EXACT [] synonym: "positive regulation of B-cell tolerance induction" EXACT [] synonym: "positive regulation of B-lymphocyte tolerance induction" EXACT [] synonym: "stimulation of B cell tolerance induction" NARROW [] synonym: "up regulation of B cell tolerance induction" EXACT [] synonym: "up-regulation of B cell tolerance induction" EXACT [] synonym: "upregulation of B cell tolerance induction" EXACT [] is_a: GO:0002645 ! positive regulation of tolerance induction is_a: GO:0002661 ! regulation of B cell tolerance induction intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0002514 ! positively regulates B cell tolerance induction relationship: RO:0002213 GO:0002514 ! positively regulates B cell tolerance induction property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4895 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0002664 name: regulation of T cell tolerance induction namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of T cell tolerance induction." [GOC:add] synonym: "regulation of T lymphocyte tolerance induction" EXACT [] synonym: "regulation of T-cell tolerance induction" EXACT [] synonym: "regulation of T-lymphocyte tolerance induction" EXACT [] is_a: GO:0002643 ! regulation of tolerance induction intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0002517 ! regulates T cell tolerance induction relationship: RO:0002211 GO:0002517 ! regulates T cell tolerance induction property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4895 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0002665 name: negative regulation of T cell tolerance induction namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of T cell tolerance induction." [GOC:add] synonym: "down regulation of T cell tolerance induction" EXACT [] synonym: "down-regulation of T cell tolerance induction" EXACT [] synonym: "downregulation of T cell tolerance induction" EXACT [] synonym: "inhibition of T cell tolerance induction" NARROW [] synonym: "negative regulation of T lymphocyte tolerance induction" EXACT [] synonym: "negative regulation of T-cell tolerance induction" EXACT [] synonym: "negative regulation of T-lymphocyte tolerance induction" EXACT [] is_a: GO:0002644 ! negative regulation of tolerance induction is_a: GO:0002664 ! regulation of T cell tolerance induction intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0002517 ! negatively regulates T cell tolerance induction relationship: RO:0002212 GO:0002517 ! negatively regulates T cell tolerance induction property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4895 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0002666 name: positive regulation of T cell tolerance induction namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of T cell tolerance induction." [GOC:add] synonym: "activation of T cell tolerance induction" NARROW [] synonym: "positive regulation of T lymphocyte tolerance induction" EXACT [] synonym: "positive regulation of T-cell tolerance induction" EXACT [] synonym: "positive regulation of T-lymphocyte tolerance induction" EXACT [] synonym: "stimulation of T cell tolerance induction" NARROW [] synonym: "up regulation of T cell tolerance induction" EXACT [] synonym: "up-regulation of T cell tolerance induction" EXACT [] synonym: "upregulation of T cell tolerance induction" EXACT [] is_a: GO:0002645 ! positive regulation of tolerance induction is_a: GO:0002664 ! regulation of T cell tolerance induction intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0002517 ! positively regulates T cell tolerance induction relationship: RO:0002213 GO:0002517 ! positively regulates T cell tolerance induction property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4895 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0002667 name: regulation of T cell anergy namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of T cell anergy." [GOC:add] synonym: "regulation of T lymphocyte anergy" EXACT [] synonym: "regulation of T-cell anergy" EXACT [] synonym: "regulation of T-lymphocyte anergy" EXACT [] is_a: GO:0002664 ! regulation of T cell tolerance induction is_a: GO:0002911 ! regulation of lymphocyte anergy intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0002870 ! regulates T cell anergy relationship: RO:0002211 GO:0002870 ! regulates T cell anergy property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4895 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0002668 name: negative regulation of T cell anergy namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of T cell anergy." [GOC:add] synonym: "down regulation of T cell anergy" EXACT [] synonym: "down-regulation of T cell anergy" EXACT [] synonym: "downregulation of T cell anergy" EXACT [] synonym: "inhibition of T cell anergy" NARROW [] synonym: "negative regulation of T lymphocyte anergy" EXACT [] synonym: "negative regulation of T-cell anergy" EXACT [] synonym: "negative regulation of T-lymphocyte anergy" EXACT [] is_a: GO:0002665 ! negative regulation of T cell tolerance induction is_a: GO:0002667 ! regulation of T cell anergy is_a: GO:0002912 ! negative regulation of lymphocyte anergy intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0002870 ! negatively regulates T cell anergy relationship: RO:0002212 GO:0002870 ! negatively regulates T cell anergy property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4895 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0002669 name: positive regulation of T cell anergy namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of T cell anergy." [GOC:add] synonym: "activation of T cell anergy" NARROW [] synonym: "positive regulation of T lymphocyte anergy" EXACT [] synonym: "positive regulation of T-cell anergy" EXACT [] synonym: "positive regulation of T-lymphocyte anergy" EXACT [] synonym: "stimulation of T cell anergy" NARROW [] synonym: "up regulation of T cell anergy" EXACT [] synonym: "up-regulation of T cell anergy" EXACT [] synonym: "upregulation of T cell anergy" EXACT [] is_a: GO:0002666 ! positive regulation of T cell tolerance induction is_a: GO:0002667 ! regulation of T cell anergy is_a: GO:0002913 ! positive regulation of lymphocyte anergy intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0002870 ! positively regulates T cell anergy relationship: RO:0002213 GO:0002870 ! positively regulates T cell anergy property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4895 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0002670 name: regulation of B cell anergy namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of B cell anergy." [GOC:add] synonym: "regulation of B lymphocyte anergy" EXACT [] synonym: "regulation of B-cell anergy" EXACT [] synonym: "regulation of B-lymphocyte anergy" EXACT [] is_a: GO:0002661 ! regulation of B cell tolerance induction is_a: GO:0002911 ! regulation of lymphocyte anergy intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0002515 ! regulates B cell anergy relationship: RO:0002211 GO:0002515 ! regulates B cell anergy property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4895 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0002671 name: negative regulation of B cell anergy namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of B cell anergy." [GOC:add] synonym: "down regulation of B cell anergy" EXACT [] synonym: "down-regulation of B cell anergy" EXACT [] synonym: "downregulation of B cell anergy" EXACT [] synonym: "inhibition of B cell anergy" NARROW [] synonym: "negative regulation of B lymphocyte anergy" EXACT [] synonym: "negative regulation of B-cell anergy" EXACT [] synonym: "negative regulation of B-lymphocyte anergy" EXACT [] is_a: GO:0002662 ! negative regulation of B cell tolerance induction is_a: GO:0002670 ! regulation of B cell anergy is_a: GO:0002912 ! negative regulation of lymphocyte anergy intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0002515 ! negatively regulates B cell anergy relationship: RO:0002212 GO:0002515 ! negatively regulates B cell anergy property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4895 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0002672 name: positive regulation of B cell anergy namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of B cell anergy." [GOC:add] synonym: "activation of B cell anergy" NARROW [] synonym: "positive regulation of B lymphocyte anergy" EXACT [] synonym: "positive regulation of B-cell anergy" EXACT [] synonym: "positive regulation of B-lymphocyte anergy" EXACT [] synonym: "stimulation of B cell anergy" NARROW [] synonym: "up regulation of B cell anergy" EXACT [] synonym: "up-regulation of B cell anergy" EXACT [] synonym: "upregulation of B cell anergy" EXACT [] is_a: GO:0002663 ! positive regulation of B cell tolerance induction is_a: GO:0002670 ! regulation of B cell anergy is_a: GO:0002913 ! positive regulation of lymphocyte anergy intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0002515 ! positively regulates B cell anergy relationship: RO:0002213 GO:0002515 ! positively regulates B cell anergy property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4895 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0002673 name: regulation of acute inflammatory response namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of an acute inflammatory response." [GOC:add] is_a: GO:0050727 ! regulation of inflammatory response intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0002526 ! regulates acute inflammatory response relationship: RO:0002211 GO:0002526 ! regulates acute inflammatory response [Term] id: GO:0002674 name: negative regulation of acute inflammatory response namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of an acute inflammatory response." [GOC:add] synonym: "down regulation of acute inflammatory response" EXACT [] synonym: "down-regulation of acute inflammatory response" EXACT [] synonym: "downregulation of acute inflammatory response" EXACT [] synonym: "inhibition of acute inflammatory response" NARROW [] is_a: GO:0002673 ! regulation of acute inflammatory response is_a: GO:0050728 ! negative regulation of inflammatory response intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0002526 ! negatively regulates acute inflammatory response relationship: RO:0002212 GO:0002526 ! negatively regulates acute inflammatory response [Term] id: GO:0002675 name: positive regulation of acute inflammatory response namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of an acute inflammatory response." [GOC:add] synonym: "activation of acute inflammatory response" NARROW [] synonym: "stimulation of acute inflammatory response" NARROW [] synonym: "up regulation of acute inflammatory response" EXACT [] synonym: "up-regulation of acute inflammatory response" EXACT [] synonym: "upregulation of acute inflammatory response" EXACT [] is_a: GO:0002673 ! regulation of acute inflammatory response is_a: GO:0050729 ! positive regulation of inflammatory response intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0002526 ! positively regulates acute inflammatory response relationship: RO:0002213 GO:0002526 ! positively regulates acute inflammatory response [Term] id: GO:0002676 name: regulation of chronic inflammatory response namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of a chronic inflammatory response." [GOC:add] is_a: GO:0050727 ! regulation of inflammatory response intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0002544 ! regulates chronic inflammatory response relationship: RO:0002211 GO:0002544 ! regulates chronic inflammatory response [Term] id: GO:0002677 name: negative regulation of chronic inflammatory response namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of a chronic inflammatory response." [GOC:add] synonym: "down regulation of chronic inflammatory response" EXACT [] synonym: "down-regulation of chronic inflammatory response" EXACT [] synonym: "downregulation of chronic inflammatory response" EXACT [] synonym: "inhibition of chronic inflammatory response" NARROW [] is_a: GO:0002676 ! regulation of chronic inflammatory response is_a: GO:0050728 ! negative regulation of inflammatory response intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0002544 ! negatively regulates chronic inflammatory response relationship: RO:0002212 GO:0002544 ! negatively regulates chronic inflammatory response [Term] id: GO:0002678 name: positive regulation of chronic inflammatory response namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of a chronic inflammatory response." [GOC:add] synonym: "activation of chronic inflammatory response" NARROW [] synonym: "stimulation of chronic inflammatory response" NARROW [] synonym: "up regulation of chronic inflammatory response" EXACT [] synonym: "up-regulation of chronic inflammatory response" EXACT [] synonym: "upregulation of chronic inflammatory response" EXACT [] is_a: GO:0002676 ! regulation of chronic inflammatory response is_a: GO:0050729 ! positive regulation of inflammatory response intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0002544 ! positively regulates chronic inflammatory response relationship: RO:0002213 GO:0002544 ! positively regulates chronic inflammatory response [Term] id: GO:0002679 name: respiratory burst involved in defense response namespace: biological_process def: "A phase of elevated metabolic activity, during which oxygen consumption increases made as part of a defense response ; this leads to the production, by an NADH dependent system, of hydrogen peroxide (H2O2), superoxide anions and hydroxyl radicals." [GOC:add, ISBN:0781735149, PMID:12789499] is_a: GO:0002252 ! immune effector process is_a: GO:0045730 ! respiratory burst intersection_of: GO:0045730 ! respiratory burst intersection_of: BFO:0000050 GO:0006952 ! part of defense response relationship: BFO:0000050 GO:0006952 ! part of defense response property_value: RO:0002161 NCBITaxon:4895 [Term] id: GO:0002682 name: regulation of immune system process namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of an immune system process." [GOC:add] is_a: GO:0050789 ! regulation of biological process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0002376 ! regulates immune system process relationship: RO:0002211 GO:0002376 ! regulates immune system process property_value: RO:0002161 NCBITaxon:4895 [Term] id: GO:0002683 name: negative regulation of immune system process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of an immune system process." [GOC:add] synonym: "down regulation of immune system process" EXACT [] synonym: "down-regulation of immune system process" EXACT [] synonym: "downregulation of immune system process" EXACT [] synonym: "inhibition of immune system process" NARROW [] is_a: GO:0002682 ! regulation of immune system process is_a: GO:0048519 ! negative regulation of biological process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0002376 ! negatively regulates immune system process relationship: RO:0002212 GO:0002376 ! negatively regulates immune system process property_value: RO:0002161 NCBITaxon:4895 [Term] id: GO:0002684 name: positive regulation of immune system process namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of an immune system process." [GOC:add] synonym: "activation of immune system process" NARROW [] synonym: "stimulation of immune system process" NARROW [] synonym: "up regulation of immune system process" EXACT [] synonym: "up-regulation of immune system process" EXACT [] synonym: "upregulation of immune system process" EXACT [] is_a: GO:0002682 ! regulation of immune system process is_a: GO:0048518 ! positive regulation of biological process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0002376 ! positively regulates immune system process relationship: RO:0002213 GO:0002376 ! positively regulates immune system process property_value: RO:0002161 NCBITaxon:4895 [Term] id: GO:0002685 name: regulation of leukocyte migration namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of leukocyte migration." [GOC:add] synonym: "regulation of immune cell migration" EXACT [] synonym: "regulation of leucocyte migration" EXACT [] is_a: GO:0002682 ! regulation of immune system process is_a: GO:0030334 ! regulation of cell migration intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0050900 ! regulates leukocyte migration relationship: RO:0002211 GO:0050900 ! regulates leukocyte migration [Term] id: GO:0002686 name: negative regulation of leukocyte migration namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of leukocyte migration." [GOC:add] synonym: "down regulation of leukocyte migration" EXACT [] synonym: "down-regulation of leukocyte migration" EXACT [] synonym: "downregulation of leukocyte migration" EXACT [] synonym: "inhibition of leukocyte migration" NARROW [] synonym: "negative regulation of immune cell migration" EXACT [] synonym: "negative regulation of leucocyte migration" EXACT [] is_a: GO:0002683 ! negative regulation of immune system process is_a: GO:0002685 ! regulation of leukocyte migration is_a: GO:0030336 ! negative regulation of cell migration intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0050900 ! negatively regulates leukocyte migration relationship: RO:0002212 GO:0050900 ! negatively regulates leukocyte migration [Term] id: GO:0002687 name: positive regulation of leukocyte migration namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of leukocyte migration." [GOC:add] synonym: "activation of leukocyte migration" NARROW [] synonym: "positive regulation of immune cell migration" EXACT [] synonym: "positive regulation of leucocyte migration" EXACT [] synonym: "stimulation of leukocyte migration" NARROW [] synonym: "up regulation of leukocyte migration" EXACT [] synonym: "up-regulation of leukocyte migration" EXACT [] synonym: "upregulation of leukocyte migration" EXACT [] is_a: GO:0002684 ! positive regulation of immune system process is_a: GO:0002685 ! regulation of leukocyte migration is_a: GO:0030335 ! positive regulation of cell migration intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0050900 ! positively regulates leukocyte migration relationship: RO:0002213 GO:0050900 ! positively regulates leukocyte migration [Term] id: GO:0002688 name: regulation of leukocyte chemotaxis namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of leukocyte chemotaxis." [GOC:add] synonym: "regulation of immune cell chemotaxis" EXACT [] synonym: "regulation of leucocyte chemotaxis" EXACT [] is_a: GO:0002685 ! regulation of leukocyte migration is_a: GO:0050920 ! regulation of chemotaxis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0030595 ! regulates leukocyte chemotaxis relationship: RO:0002211 GO:0030595 ! regulates leukocyte chemotaxis [Term] id: GO:0002689 name: negative regulation of leukocyte chemotaxis namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of leukocyte chemotaxis." [GOC:add] synonym: "down regulation of leukocyte chemotaxis" EXACT [] synonym: "down-regulation of leukocyte chemotaxis" EXACT [] synonym: "downregulation of leukocyte chemotaxis" EXACT [] synonym: "inhibition of leukocyte chemotaxis" NARROW [] synonym: "negative regulation of immune cell chemotaxis" EXACT [] synonym: "negative regulation of leucocyte chemotaxis" EXACT [] is_a: GO:0002686 ! negative regulation of leukocyte migration is_a: GO:0002688 ! regulation of leukocyte chemotaxis is_a: GO:0050922 ! negative regulation of chemotaxis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0030595 ! negatively regulates leukocyte chemotaxis relationship: RO:0002212 GO:0030595 ! negatively regulates leukocyte chemotaxis [Term] id: GO:0002690 name: positive regulation of leukocyte chemotaxis namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of leukocyte chemotaxis." [GOC:add] synonym: "activation of leukocyte chemotaxis" NARROW [] synonym: "positive regulation of immune cell chemotaxis" EXACT [] synonym: "positive regulation of leucocyte chemotaxis" EXACT [] synonym: "stimulation of leukocyte chemotaxis" NARROW [] synonym: "up regulation of leukocyte chemotaxis" EXACT [] synonym: "up-regulation of leukocyte chemotaxis" EXACT [] synonym: "upregulation of leukocyte chemotaxis" EXACT [] is_a: GO:0002687 ! positive regulation of leukocyte migration is_a: GO:0002688 ! regulation of leukocyte chemotaxis is_a: GO:0050921 ! positive regulation of chemotaxis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0030595 ! positively regulates leukocyte chemotaxis relationship: RO:0002213 GO:0030595 ! positively regulates leukocyte chemotaxis [Term] id: GO:0002694 name: regulation of leukocyte activation namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of leukocyte activation." [GOC:add] synonym: "regulation of immune cell activation" EXACT [] synonym: "regulation of leucocyte activation" EXACT [] is_a: GO:0002682 ! regulation of immune system process is_a: GO:0050865 ! regulation of cell activation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0045321 ! regulates leukocyte activation relationship: RO:0002211 GO:0045321 ! regulates leukocyte activation [Term] id: GO:0002695 name: negative regulation of leukocyte activation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of leukocyte activation." [GOC:add] synonym: "down regulation of leukocyte activation" EXACT [] synonym: "down-regulation of leukocyte activation" EXACT [] synonym: "downregulation of leukocyte activation" EXACT [] synonym: "inhibition of leukocyte activation" NARROW [] synonym: "negative regulation of immune cell activation" EXACT [] synonym: "negative regulation of leucocyte activation" EXACT [] is_a: GO:0002683 ! negative regulation of immune system process is_a: GO:0002694 ! regulation of leukocyte activation is_a: GO:0050866 ! negative regulation of cell activation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0045321 ! negatively regulates leukocyte activation relationship: RO:0002212 GO:0045321 ! negatively regulates leukocyte activation [Term] id: GO:0002696 name: positive regulation of leukocyte activation namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of leukocyte activation." [GOC:add] synonym: "activation of leukocyte activation" NARROW [] synonym: "positive regulation of immune cell activation" EXACT [] synonym: "positive regulation of leucocyte activation" EXACT [] synonym: "stimulation of leukocyte activation" NARROW [] synonym: "up regulation of leukocyte activation" EXACT [] synonym: "up-regulation of leukocyte activation" EXACT [] synonym: "upregulation of leukocyte activation" EXACT [] is_a: GO:0002684 ! positive regulation of immune system process is_a: GO:0002694 ! regulation of leukocyte activation is_a: GO:0050867 ! positive regulation of cell activation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0045321 ! positively regulates leukocyte activation relationship: RO:0002213 GO:0045321 ! positively regulates leukocyte activation [Term] id: GO:0002697 name: regulation of immune effector process namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of an immune effector process." [GOC:add] is_a: GO:0002682 ! regulation of immune system process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0002252 ! regulates immune effector process relationship: RO:0002211 GO:0002252 ! regulates immune effector process property_value: RO:0002161 NCBITaxon:4895 [Term] id: GO:0002698 name: negative regulation of immune effector process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of an immune effector process." [GOC:add] synonym: "down regulation of immune effector process" EXACT [] synonym: "down-regulation of immune effector process" EXACT [] synonym: "downregulation of immune effector process" EXACT [] synonym: "inhibition of immune effector process" NARROW [] is_a: GO:0002683 ! negative regulation of immune system process is_a: GO:0002697 ! regulation of immune effector process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0002252 ! negatively regulates immune effector process relationship: RO:0002212 GO:0002252 ! negatively regulates immune effector process property_value: RO:0002161 NCBITaxon:4895 [Term] id: GO:0002699 name: positive regulation of immune effector process namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of an immune effector process." [GOC:add] synonym: "activation of immune effector process" NARROW [] synonym: "stimulation of immune effector process" NARROW [] synonym: "up regulation of immune effector process" EXACT [] synonym: "up-regulation of immune effector process" EXACT [] synonym: "upregulation of immune effector process" EXACT [] is_a: GO:0002684 ! positive regulation of immune system process is_a: GO:0002697 ! regulation of immune effector process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0002252 ! positively regulates immune effector process relationship: RO:0002213 GO:0002252 ! positively regulates immune effector process property_value: RO:0002161 NCBITaxon:4895 [Term] id: GO:0002700 name: regulation of production of molecular mediator of immune response namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of the production of molecular mediator of immune response." [GOC:add] is_a: GO:0002697 ! regulation of immune effector process is_a: GO:0010468 ! regulation of gene expression intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0002440 ! regulates production of molecular mediator of immune response relationship: RO:0002211 GO:0002440 ! regulates production of molecular mediator of immune response property_value: RO:0002161 NCBITaxon:4895 [Term] id: GO:0002701 name: negative regulation of production of molecular mediator of immune response namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of the production of molecular mediator of immune response." [GOC:add] synonym: "down regulation of production of molecular mediator of immune response" EXACT [] synonym: "down-regulation of production of molecular mediator of immune response" EXACT [] synonym: "downregulation of production of molecular mediator of immune response" EXACT [] synonym: "inhibition of production of molecular mediator of immune response" NARROW [] is_a: GO:0002698 ! negative regulation of immune effector process is_a: GO:0002700 ! regulation of production of molecular mediator of immune response is_a: GO:0010629 ! negative regulation of gene expression intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0002440 ! negatively regulates production of molecular mediator of immune response relationship: RO:0002212 GO:0002440 ! negatively regulates production of molecular mediator of immune response property_value: RO:0002161 NCBITaxon:4895 [Term] id: GO:0002702 name: positive regulation of production of molecular mediator of immune response namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of the production of molecular mediator of immune response." [GOC:add] synonym: "activation of production of molecular mediator of immune response" NARROW [] synonym: "stimulation of production of molecular mediator of immune response" NARROW [] synonym: "up regulation of production of molecular mediator of immune response" EXACT [] synonym: "up-regulation of production of molecular mediator of immune response" EXACT [] synonym: "upregulation of production of molecular mediator of immune response" EXACT [] is_a: GO:0002699 ! positive regulation of immune effector process is_a: GO:0002700 ! regulation of production of molecular mediator of immune response is_a: GO:0010628 ! positive regulation of gene expression intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0002440 ! positively regulates production of molecular mediator of immune response relationship: RO:0002213 GO:0002440 ! positively regulates production of molecular mediator of immune response property_value: RO:0002161 NCBITaxon:4895 [Term] id: GO:0002703 name: regulation of leukocyte mediated immunity namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of leukocyte mediated immunity." [GOC:add] synonym: "regulation of immune cell mediated immunity" EXACT [] synonym: "regulation of leucocyte mediated immunity" EXACT [] is_a: GO:0002697 ! regulation of immune effector process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0002443 ! regulates leukocyte mediated immunity relationship: RO:0002211 GO:0002443 ! regulates leukocyte mediated immunity [Term] id: GO:0002704 name: negative regulation of leukocyte mediated immunity namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of leukocyte mediated immunity." [GOC:add] synonym: "down regulation of leukocyte mediated immunity" EXACT [] synonym: "down-regulation of leukocyte mediated immunity" EXACT [] synonym: "downregulation of leukocyte mediated immunity" EXACT [] synonym: "inhibition of leukocyte mediated immunity" NARROW [] synonym: "negative regulation of immune cell mediated immunity" EXACT [] synonym: "negative regulation of leucocyte mediated immunity" EXACT [] is_a: GO:0002698 ! negative regulation of immune effector process is_a: GO:0002703 ! regulation of leukocyte mediated immunity intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0002443 ! negatively regulates leukocyte mediated immunity relationship: RO:0002212 GO:0002443 ! negatively regulates leukocyte mediated immunity [Term] id: GO:0002705 name: positive regulation of leukocyte mediated immunity namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of leukocyte mediated immunity." [GOC:add] synonym: "activation of leukocyte mediated immunity" NARROW [] synonym: "positive regulation of immune cell mediated immunity" EXACT [] synonym: "positive regulation of leucocyte mediated immunity" EXACT [] synonym: "stimulation of leukocyte mediated immunity" NARROW [] synonym: "up regulation of leukocyte mediated immunity" EXACT [] synonym: "up-regulation of leukocyte mediated immunity" EXACT [] synonym: "upregulation of leukocyte mediated immunity" EXACT [] is_a: GO:0002699 ! positive regulation of immune effector process is_a: GO:0002703 ! regulation of leukocyte mediated immunity intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0002443 ! positively regulates leukocyte mediated immunity relationship: RO:0002213 GO:0002443 ! positively regulates leukocyte mediated immunity [Term] id: GO:0002706 name: regulation of lymphocyte mediated immunity namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of lymphocyte mediated immunity." [GOC:add] is_a: GO:0002703 ! regulation of leukocyte mediated immunity intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0002449 ! regulates lymphocyte mediated immunity relationship: RO:0002211 GO:0002449 ! regulates lymphocyte mediated immunity [Term] id: GO:0002707 name: negative regulation of lymphocyte mediated immunity namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of lymphocyte mediated immunity." [GOC:add] synonym: "down regulation of lymphocyte mediated immunity" EXACT [] synonym: "down-regulation of lymphocyte mediated immunity" EXACT [] synonym: "downregulation of lymphocyte mediated immunity" EXACT [] synonym: "inhibition of lymphocyte mediated immunity" NARROW [] is_a: GO:0002704 ! negative regulation of leukocyte mediated immunity is_a: GO:0002706 ! regulation of lymphocyte mediated immunity intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0002449 ! negatively regulates lymphocyte mediated immunity relationship: RO:0002212 GO:0002449 ! negatively regulates lymphocyte mediated immunity [Term] id: GO:0002708 name: positive regulation of lymphocyte mediated immunity namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of lymphocyte mediated immunity." [GOC:add] synonym: "activation of lymphocyte mediated immunity" NARROW [] synonym: "stimulation of lymphocyte mediated immunity" NARROW [] synonym: "up regulation of lymphocyte mediated immunity" EXACT [] synonym: "up-regulation of lymphocyte mediated immunity" EXACT [] synonym: "upregulation of lymphocyte mediated immunity" EXACT [] is_a: GO:0002705 ! positive regulation of leukocyte mediated immunity is_a: GO:0002706 ! regulation of lymphocyte mediated immunity intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0002449 ! positively regulates lymphocyte mediated immunity relationship: RO:0002213 GO:0002449 ! positively regulates lymphocyte mediated immunity [Term] id: GO:0002709 name: regulation of T cell mediated immunity namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of T cell mediated immunity." [GOC:add] synonym: "regulation of T lymphocyte mediated immunity" EXACT [] synonym: "regulation of T-cell mediated immunity" EXACT [] synonym: "regulation of T-lymphocyte mediated immunity" EXACT [] is_a: GO:0002706 ! regulation of lymphocyte mediated immunity is_a: GO:0002822 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0002456 ! regulates T cell mediated immunity relationship: RO:0002211 GO:0002456 ! regulates T cell mediated immunity [Term] id: GO:0002710 name: negative regulation of T cell mediated immunity namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of T cell mediated immunity." [GOC:add] synonym: "down regulation of T cell mediated immunity" EXACT [] synonym: "down-regulation of T cell mediated immunity" EXACT [] synonym: "downregulation of T cell mediated immunity" EXACT [] synonym: "inhibition of T cell mediated immunity" NARROW [] synonym: "negative regulation of T lymphocyte mediated immunity" EXACT [] synonym: "negative regulation of T-cell mediated immunity" EXACT [] synonym: "negative regulation of T-lymphocyte mediated immunity" EXACT [] is_a: GO:0002707 ! negative regulation of lymphocyte mediated immunity is_a: GO:0002709 ! regulation of T cell mediated immunity is_a: GO:0002823 ! negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0002456 ! negatively regulates T cell mediated immunity relationship: RO:0002212 GO:0002456 ! negatively regulates T cell mediated immunity [Term] id: GO:0002711 name: positive regulation of T cell mediated immunity namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of T cell mediated immunity." [GOC:add] synonym: "activation of T cell mediated immunity" NARROW [] synonym: "positive regulation of T lymphocyte mediated immunity" EXACT [] synonym: "positive regulation of T-cell mediated immunity" EXACT [] synonym: "positive regulation of T-lymphocyte mediated immunity" EXACT [] synonym: "stimulation of T cell mediated immunity" NARROW [] synonym: "up regulation of T cell mediated immunity" EXACT [] synonym: "up-regulation of T cell mediated immunity" EXACT [] synonym: "upregulation of T cell mediated immunity" EXACT [] is_a: GO:0002708 ! positive regulation of lymphocyte mediated immunity is_a: GO:0002709 ! regulation of T cell mediated immunity is_a: GO:0002824 ! positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0002456 ! positively regulates T cell mediated immunity relationship: RO:0002213 GO:0002456 ! positively regulates T cell mediated immunity [Term] id: GO:0002712 name: regulation of B cell mediated immunity namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of B cell mediated immunity." [GOC:add] synonym: "regulation of B lymphocyte mediated immunity" EXACT [] synonym: "regulation of B-cell mediated immunity" EXACT [] synonym: "regulation of B-lymphocyte mediated immunity" EXACT [] is_a: GO:0002706 ! regulation of lymphocyte mediated immunity is_a: GO:0002822 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0019724 ! regulates B cell mediated immunity relationship: RO:0002211 GO:0019724 ! regulates B cell mediated immunity [Term] id: GO:0002713 name: negative regulation of B cell mediated immunity namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of B cell mediated immunity." [GOC:add] synonym: "down regulation of B cell mediated immunity" EXACT [] synonym: "down-regulation of B cell mediated immunity" EXACT [] synonym: "downregulation of B cell mediated immunity" EXACT [] synonym: "inhibition of B cell mediated immunity" NARROW [] synonym: "negative regulation of B lymphocyte mediated immunity" EXACT [] synonym: "negative regulation of B-cell mediated immunity" EXACT [] synonym: "negative regulation of B-lymphocyte mediated immunity" EXACT [] is_a: GO:0002707 ! negative regulation of lymphocyte mediated immunity is_a: GO:0002712 ! regulation of B cell mediated immunity is_a: GO:0002823 ! negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0019724 ! negatively regulates B cell mediated immunity relationship: RO:0002212 GO:0019724 ! negatively regulates B cell mediated immunity [Term] id: GO:0002714 name: positive regulation of B cell mediated immunity namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of B cell mediated immunity." [GOC:add] synonym: "activation of B cell mediated immunity" NARROW [] synonym: "positive regulation of B lymphocyte mediated immunity" EXACT [] synonym: "positive regulation of B-cell mediated immunity" EXACT [] synonym: "positive regulation of B-lymphocyte mediated immunity" EXACT [] synonym: "stimulation of B cell mediated immunity" NARROW [] synonym: "up regulation of B cell mediated immunity" EXACT [] synonym: "up-regulation of B cell mediated immunity" EXACT [] synonym: "upregulation of B cell mediated immunity" EXACT [] is_a: GO:0002708 ! positive regulation of lymphocyte mediated immunity is_a: GO:0002712 ! regulation of B cell mediated immunity is_a: GO:0002824 ! positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0019724 ! positively regulates B cell mediated immunity relationship: RO:0002213 GO:0019724 ! positively regulates B cell mediated immunity [Term] id: GO:0002715 name: regulation of natural killer cell mediated immunity namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of natural killer cell mediated immunity." [GOC:add] synonym: "regulation of natural killer cell activity" RELATED [] synonym: "regulation of NK cell mediated immunity" EXACT [] is_a: GO:0002706 ! regulation of lymphocyte mediated immunity is_a: GO:0045088 ! regulation of innate immune response intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0002228 ! regulates natural killer cell mediated immunity relationship: RO:0002211 GO:0002228 ! regulates natural killer cell mediated immunity [Term] id: GO:0002716 name: negative regulation of natural killer cell mediated immunity namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of natural killer cell mediated immunity." [GOC:add] synonym: "down regulation of natural killer cell mediated immunity" EXACT [] synonym: "down-regulation of natural killer cell mediated immunity" EXACT [] synonym: "downregulation of natural killer cell mediated immunity" EXACT [] synonym: "inhibition of natural killer cell mediated immunity" NARROW [] synonym: "negative regulation of natural killer cell activity" RELATED [] synonym: "negative regulation of NK cell activity" RELATED [] synonym: "negative regulation of NK cell mediated immunity" EXACT [] is_a: GO:0002707 ! negative regulation of lymphocyte mediated immunity is_a: GO:0002715 ! regulation of natural killer cell mediated immunity is_a: GO:0045824 ! negative regulation of innate immune response intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0002228 ! negatively regulates natural killer cell mediated immunity relationship: RO:0002212 GO:0002228 ! negatively regulates natural killer cell mediated immunity [Term] id: GO:0002717 name: positive regulation of natural killer cell mediated immunity namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of natural killer cell mediated immunity." [GOC:add] synonym: "activation of natural killer cell mediated immunity" NARROW [] synonym: "positive regulation of natural killer cell activity" RELATED [] synonym: "positive regulation of NK cell activity" RELATED [] synonym: "positive regulation of NK cell mediated immunity" EXACT [] synonym: "stimulation of natural killer cell mediated immunity" NARROW [] synonym: "up regulation of natural killer cell mediated immunity" EXACT [] synonym: "up-regulation of natural killer cell mediated immunity" EXACT [] synonym: "upregulation of natural killer cell mediated immunity" EXACT [] is_a: GO:0002708 ! positive regulation of lymphocyte mediated immunity is_a: GO:0002715 ! regulation of natural killer cell mediated immunity is_a: GO:0045089 ! positive regulation of innate immune response intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0002228 ! positively regulates natural killer cell mediated immunity relationship: RO:0002213 GO:0002228 ! positively regulates natural killer cell mediated immunity [Term] id: GO:0002718 name: regulation of cytokine production involved in immune response namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of cytokine production that contributes to an immune response." [GOC:add] synonym: "regulation of cytokine biosynthetic process involved in immune response" NARROW [] synonym: "regulation of cytokine production during immune response" RELATED [GOC:dph] synonym: "regulation of cytokine secretion involved in immune response" NARROW [] is_a: GO:0001817 ! regulation of cytokine production is_a: GO:0002700 ! regulation of production of molecular mediator of immune response intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0002367 ! regulates cytokine production involved in immune response relationship: RO:0002211 GO:0002367 ! regulates cytokine production involved in immune response property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4895 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0002719 name: negative regulation of cytokine production involved in immune response namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of cytokine production contributing to an immune response." [GOC:add] synonym: "down regulation of cytokine production during immune response" RELATED [] synonym: "down-regulation of cytokine production during immune response" EXACT [] synonym: "downregulation of cytokine production during immune response" RELATED [] synonym: "inhibition of cytokine production during immune response" RELATED [] synonym: "negative regulation of cytokine biosynthetic process involved in immune response" NARROW [] synonym: "negative regulation of cytokine production during immune response" RELATED [GOC:dph] synonym: "negative regulation of cytokine secretion involved in immune response" NARROW [] is_a: GO:0001818 ! negative regulation of cytokine production is_a: GO:0002701 ! negative regulation of production of molecular mediator of immune response is_a: GO:0002718 ! regulation of cytokine production involved in immune response intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0002367 ! negatively regulates cytokine production involved in immune response relationship: RO:0002212 GO:0002367 ! negatively regulates cytokine production involved in immune response property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4895 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0002720 name: positive regulation of cytokine production involved in immune response namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of cytokine production that contributes to an immune response." [GOC:add] synonym: "activation of cytokine production during immune response" NARROW [] synonym: "positive regulation of cytokine biosynthetic process involved in immune response" NARROW [] synonym: "positive regulation of cytokine production during immune response" RELATED [GOC:dph] synonym: "positive regulation of cytokine secretion involved in immune response" NARROW [] synonym: "stimulation of cytokine production during immune response" NARROW [] synonym: "up regulation of cytokine production during immune response" RELATED [] synonym: "up-regulation of cytokine production during immune response" RELATED [] synonym: "upregulation of cytokine production during immune response" RELATED [] is_a: GO:0001819 ! positive regulation of cytokine production is_a: GO:0002702 ! positive regulation of production of molecular mediator of immune response is_a: GO:0002718 ! regulation of cytokine production involved in immune response intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0002367 ! positively regulates cytokine production involved in immune response relationship: RO:0002213 GO:0002367 ! positively regulates cytokine production involved in immune response property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4895 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0002721 name: regulation of B cell cytokine production namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of B cell cytokine production." [GOC:add] synonym: "regulation of B lymphocyte cytokine production" EXACT [] synonym: "regulation of B-cell cytokine production" EXACT [] synonym: "regulation of B-lymphocyte cytokine production" EXACT [] is_a: GO:0002712 ! regulation of B cell mediated immunity is_a: GO:0002718 ! regulation of cytokine production involved in immune response intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0002368 ! regulates B cell cytokine production relationship: RO:0002211 GO:0002368 ! regulates B cell cytokine production [Term] id: GO:0002722 name: negative regulation of B cell cytokine production namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of B cell cytokine production." [GOC:add] synonym: "down regulation of B cell cytokine production" EXACT [] synonym: "down-regulation of B cell cytokine production" EXACT [] synonym: "downregulation of B cell cytokine production" EXACT [] synonym: "inhibition of B cell cytokine production" NARROW [] synonym: "negative regulation of B lymphocyte cytokine production" EXACT [] synonym: "negative regulation of B-cell cytokine production" EXACT [] synonym: "negative regulation of B-lymphocyte cytokine production" EXACT [] is_a: GO:0002713 ! negative regulation of B cell mediated immunity is_a: GO:0002719 ! negative regulation of cytokine production involved in immune response is_a: GO:0002721 ! regulation of B cell cytokine production intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0002368 ! negatively regulates B cell cytokine production relationship: RO:0002212 GO:0002368 ! negatively regulates B cell cytokine production [Term] id: GO:0002723 name: positive regulation of B cell cytokine production namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of B cell cytokine production." [GOC:add] synonym: "activation of B cell cytokine production" NARROW [] synonym: "positive regulation of B lymphocyte cytokine production" EXACT [] synonym: "positive regulation of B-cell cytokine production" EXACT [] synonym: "positive regulation of B-lymphocyte cytokine production" EXACT [] synonym: "stimulation of B cell cytokine production" NARROW [] synonym: "up regulation of B cell cytokine production" EXACT [] synonym: "up-regulation of B cell cytokine production" EXACT [] synonym: "upregulation of B cell cytokine production" EXACT [] is_a: GO:0002714 ! positive regulation of B cell mediated immunity is_a: GO:0002720 ! positive regulation of cytokine production involved in immune response is_a: GO:0002721 ! regulation of B cell cytokine production intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0002368 ! positively regulates B cell cytokine production relationship: RO:0002213 GO:0002368 ! positively regulates B cell cytokine production [Term] id: GO:0002724 name: regulation of T cell cytokine production namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of T cell cytokine production." [GOC:add] synonym: "regulation of T lymphocyte cytokine production" EXACT [] synonym: "regulation of T-cell cytokine production" EXACT [] synonym: "regulation of T-lymphocyte cytokine production" EXACT [] is_a: GO:0002709 ! regulation of T cell mediated immunity is_a: GO:0002718 ! regulation of cytokine production involved in immune response intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0002369 ! regulates T cell cytokine production relationship: RO:0002211 GO:0002369 ! regulates T cell cytokine production [Term] id: GO:0002725 name: negative regulation of T cell cytokine production namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of T cell cytokine production." [GOC:add] synonym: "down regulation of T cell cytokine production" EXACT [] synonym: "down-regulation of T cell cytokine production" EXACT [] synonym: "downregulation of T cell cytokine production" EXACT [] synonym: "inhibition of T cell cytokine production" NARROW [] synonym: "negative regulation of T lymphocyte cytokine production" EXACT [] synonym: "negative regulation of T-cell cytokine production" EXACT [] synonym: "negative regulation of T-lymphocyte cytokine production" EXACT [] is_a: GO:0002710 ! negative regulation of T cell mediated immunity is_a: GO:0002719 ! negative regulation of cytokine production involved in immune response is_a: GO:0002724 ! regulation of T cell cytokine production intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0002369 ! negatively regulates T cell cytokine production relationship: RO:0002212 GO:0002369 ! negatively regulates T cell cytokine production [Term] id: GO:0002726 name: positive regulation of T cell cytokine production namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of T cell cytokine production." [GOC:add] synonym: "activation of T cell cytokine production" NARROW [] synonym: "positive regulation of T lymphocyte cytokine production" EXACT [] synonym: "positive regulation of T-cell cytokine production" EXACT [] synonym: "positive regulation of T-lymphocyte cytokine production" EXACT [] synonym: "stimulation of T cell cytokine production" NARROW [] synonym: "up regulation of T cell cytokine production" EXACT [] synonym: "up-regulation of T cell cytokine production" EXACT [] synonym: "upregulation of T cell cytokine production" EXACT [] is_a: GO:0002711 ! positive regulation of T cell mediated immunity is_a: GO:0002720 ! positive regulation of cytokine production involved in immune response is_a: GO:0002724 ! regulation of T cell cytokine production intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0002369 ! positively regulates T cell cytokine production relationship: RO:0002213 GO:0002369 ! positively regulates T cell cytokine production [Term] id: GO:0002727 name: regulation of natural killer cell cytokine production namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of natural killer cell cytokine production." [GOC:add] synonym: "regulation of NK cell cytokine production" EXACT [] is_a: GO:0002715 ! regulation of natural killer cell mediated immunity is_a: GO:0002718 ! regulation of cytokine production involved in immune response intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0002370 ! regulates natural killer cell cytokine production relationship: RO:0002211 GO:0002370 ! regulates natural killer cell cytokine production [Term] id: GO:0002728 name: negative regulation of natural killer cell cytokine production namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of natural killer cell cytokine production." [GOC:add] synonym: "down regulation of natural killer cell cytokine production" EXACT [] synonym: "down-regulation of natural killer cell cytokine production" EXACT [] synonym: "downregulation of natural killer cell cytokine production" EXACT [] synonym: "inhibition of natural killer cell cytokine production" NARROW [] synonym: "negative regulation of NK cell cytokine production" EXACT [] is_a: GO:0002716 ! negative regulation of natural killer cell mediated immunity is_a: GO:0002719 ! negative regulation of cytokine production involved in immune response is_a: GO:0002727 ! regulation of natural killer cell cytokine production intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0002370 ! negatively regulates natural killer cell cytokine production relationship: RO:0002212 GO:0002370 ! negatively regulates natural killer cell cytokine production [Term] id: GO:0002729 name: positive regulation of natural killer cell cytokine production namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of natural killer cell cytokine production." [GOC:add] synonym: "activation of natural killer cell cytokine production" NARROW [] synonym: "positive regulation of NK cell cytokine production" EXACT [] synonym: "stimulation of natural killer cell cytokine production" NARROW [] synonym: "up regulation of natural killer cell cytokine production" EXACT [] synonym: "up-regulation of natural killer cell cytokine production" EXACT [] synonym: "upregulation of natural killer cell cytokine production" EXACT [] is_a: GO:0002717 ! positive regulation of natural killer cell mediated immunity is_a: GO:0002720 ! positive regulation of cytokine production involved in immune response is_a: GO:0002727 ! regulation of natural killer cell cytokine production intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0002370 ! positively regulates natural killer cell cytokine production relationship: RO:0002213 GO:0002370 ! positively regulates natural killer cell cytokine production [Term] id: GO:0002730 name: regulation of dendritic cell cytokine production namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of dendritic cell cytokine production." [GOC:add] is_a: GO:0002703 ! regulation of leukocyte mediated immunity is_a: GO:0002718 ! regulation of cytokine production involved in immune response intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0002371 ! regulates dendritic cell cytokine production relationship: RO:0002211 GO:0002371 ! regulates dendritic cell cytokine production [Term] id: GO:0002731 name: negative regulation of dendritic cell cytokine production namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of dendritic cell cytokine production." [GOC:add] synonym: "down regulation of dendritic cell cytokine production" EXACT [] synonym: "down-regulation of dendritic cell cytokine production" EXACT [] synonym: "downregulation of dendritic cell cytokine production" EXACT [] synonym: "inhibition of dendritic cell cytokine production" NARROW [] is_a: GO:0002704 ! negative regulation of leukocyte mediated immunity is_a: GO:0002719 ! negative regulation of cytokine production involved in immune response is_a: GO:0002730 ! regulation of dendritic cell cytokine production intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0002371 ! negatively regulates dendritic cell cytokine production relationship: RO:0002212 GO:0002371 ! negatively regulates dendritic cell cytokine production [Term] id: GO:0002732 name: positive regulation of dendritic cell cytokine production namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of dendritic cell cytokine production." [GOC:add] synonym: "activation of dendritic cell cytokine production" NARROW [] synonym: "stimulation of dendritic cell cytokine production" NARROW [] synonym: "up regulation of dendritic cell cytokine production" EXACT [] synonym: "up-regulation of dendritic cell cytokine production" EXACT [] synonym: "upregulation of dendritic cell cytokine production" EXACT [] is_a: GO:0002705 ! positive regulation of leukocyte mediated immunity is_a: GO:0002720 ! positive regulation of cytokine production involved in immune response is_a: GO:0002730 ! regulation of dendritic cell cytokine production intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0002371 ! positively regulates dendritic cell cytokine production relationship: RO:0002213 GO:0002371 ! positively regulates dendritic cell cytokine production [Term] id: GO:0002733 name: regulation of myeloid dendritic cell cytokine production namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of myeloid dendritic cell cytokine production." [GOC:add] is_a: GO:0002730 ! regulation of dendritic cell cytokine production is_a: GO:0002886 ! regulation of myeloid leukocyte mediated immunity intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0002372 ! regulates myeloid dendritic cell cytokine production relationship: RO:0002211 GO:0002372 ! regulates myeloid dendritic cell cytokine production [Term] id: GO:0002734 name: negative regulation of myeloid dendritic cell cytokine production namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of myeloid dendritic cell cytokine production." [GOC:add] synonym: "down regulation of myeloid dendritic cell cytokine production" EXACT [] synonym: "down-regulation of myeloid dendritic cell cytokine production" EXACT [] synonym: "downregulation of myeloid dendritic cell cytokine production" EXACT [] synonym: "inhibition of myeloid dendritic cell cytokine production" NARROW [] is_a: GO:0002731 ! negative regulation of dendritic cell cytokine production is_a: GO:0002733 ! regulation of myeloid dendritic cell cytokine production is_a: GO:0002887 ! negative regulation of myeloid leukocyte mediated immunity intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0002372 ! negatively regulates myeloid dendritic cell cytokine production relationship: RO:0002212 GO:0002372 ! negatively regulates myeloid dendritic cell cytokine production [Term] id: GO:0002735 name: positive regulation of myeloid dendritic cell cytokine production namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of myeloid dendritic cell cytokine production." [GOC:add] synonym: "activation of myeloid dendritic cell cytokine production" NARROW [] synonym: "stimulation of myeloid dendritic cell cytokine production" NARROW [] synonym: "up regulation of myeloid dendritic cell cytokine production" EXACT [] synonym: "up-regulation of myeloid dendritic cell cytokine production" EXACT [] synonym: "upregulation of myeloid dendritic cell cytokine production" EXACT [] is_a: GO:0002732 ! positive regulation of dendritic cell cytokine production is_a: GO:0002733 ! regulation of myeloid dendritic cell cytokine production is_a: GO:0002888 ! positive regulation of myeloid leukocyte mediated immunity is_a: GO:0061081 ! positive regulation of myeloid leukocyte cytokine production involved in immune response intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0002372 ! positively regulates myeloid dendritic cell cytokine production relationship: RO:0002213 GO:0002372 ! positively regulates myeloid dendritic cell cytokine production [Term] id: GO:0002736 name: regulation of plasmacytoid dendritic cell cytokine production namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of plasmacytoid dendritic cell cytokine production." [GOC:add] is_a: GO:0002730 ! regulation of dendritic cell cytokine production intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0002373 ! regulates plasmacytoid dendritic cell cytokine production relationship: RO:0002211 GO:0002373 ! regulates plasmacytoid dendritic cell cytokine production [Term] id: GO:0002737 name: negative regulation of plasmacytoid dendritic cell cytokine production namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of plasmacytoid dendritic cell cytokine production." [GOC:add] synonym: "down regulation of plasmacytoid dendritic cell cytokine production" EXACT [] synonym: "down-regulation of plasmacytoid dendritic cell cytokine production" EXACT [] synonym: "downregulation of plasmacytoid dendritic cell cytokine production" EXACT [] synonym: "inhibition of plasmacytoid dendritic cell cytokine production" NARROW [] is_a: GO:0002731 ! negative regulation of dendritic cell cytokine production is_a: GO:0002736 ! regulation of plasmacytoid dendritic cell cytokine production intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0002373 ! negatively regulates plasmacytoid dendritic cell cytokine production relationship: RO:0002212 GO:0002373 ! negatively regulates plasmacytoid dendritic cell cytokine production [Term] id: GO:0002738 name: positive regulation of plasmacytoid dendritic cell cytokine production namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of plasmacytoid dendritic cell cytokine production." [GOC:add] synonym: "activation of plasmacytoid dendritic cell cytokine production" NARROW [] synonym: "stimulation of plasmacytoid dendritic cell cytokine production" NARROW [] synonym: "up regulation of plasmacytoid dendritic cell cytokine production" EXACT [] synonym: "up-regulation of plasmacytoid dendritic cell cytokine production" EXACT [] synonym: "upregulation of plasmacytoid dendritic cell cytokine production" EXACT [] is_a: GO:0002732 ! positive regulation of dendritic cell cytokine production is_a: GO:0002736 ! regulation of plasmacytoid dendritic cell cytokine production intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0002373 ! positively regulates plasmacytoid dendritic cell cytokine production relationship: RO:0002213 GO:0002373 ! positively regulates plasmacytoid dendritic cell cytokine production [Term] id: GO:0002759 name: regulation of antimicrobial humoral response namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of an antimicrobial humoral response." [GOC:add] is_a: GO:0002831 ! regulation of response to biotic stimulus is_a: GO:0002920 ! regulation of humoral immune response is_a: GO:0031347 ! regulation of defense response is_a: GO:0032101 ! regulation of response to external stimulus intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0019730 ! regulates antimicrobial humoral response relationship: RO:0002211 GO:0019730 ! regulates antimicrobial humoral response property_value: RO:0002161 NCBITaxon:4895 [Term] id: GO:0002760 name: positive regulation of antimicrobial humoral response namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of an antimicrobial humoral response." [GOC:add] synonym: "activation of antimicrobial humoral response" NARROW [] synonym: "stimulation of antimicrobial humoral response" NARROW [] synonym: "up regulation of antimicrobial humoral response" EXACT [] synonym: "up-regulation of antimicrobial humoral response" EXACT [] synonym: "upregulation of antimicrobial humoral response" EXACT [] is_a: GO:0002759 ! regulation of antimicrobial humoral response is_a: GO:0002833 ! positive regulation of response to biotic stimulus is_a: GO:0002922 ! positive regulation of humoral immune response is_a: GO:0031349 ! positive regulation of defense response is_a: GO:0032103 ! positive regulation of response to external stimulus intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0019730 ! positively regulates antimicrobial humoral response relationship: RO:0002213 GO:0019730 ! positively regulates antimicrobial humoral response property_value: RO:0002161 NCBITaxon:4895 [Term] id: GO:0002761 name: regulation of myeloid leukocyte differentiation namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of myeloid leukocyte differentiation." [GOC:add] is_a: GO:0045637 ! regulation of myeloid cell differentiation is_a: GO:1902105 ! regulation of leukocyte differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0002573 ! regulates myeloid leukocyte differentiation relationship: RO:0002211 GO:0002573 ! regulates myeloid leukocyte differentiation [Term] id: GO:0002762 name: negative regulation of myeloid leukocyte differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of myeloid leukocyte differentiation." [GOC:add] synonym: "down regulation of myeloid leukocyte differentiation" EXACT [] synonym: "down-regulation of myeloid leukocyte differentiation" EXACT [] synonym: "downregulation of myeloid leukocyte differentiation" EXACT [] synonym: "inhibition of myeloid leukocyte differentiation" NARROW [] is_a: GO:0002761 ! regulation of myeloid leukocyte differentiation is_a: GO:0045638 ! negative regulation of myeloid cell differentiation is_a: GO:1902106 ! negative regulation of leukocyte differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0002573 ! negatively regulates myeloid leukocyte differentiation relationship: RO:0002212 GO:0002573 ! negatively regulates myeloid leukocyte differentiation [Term] id: GO:0002763 name: positive regulation of myeloid leukocyte differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of myeloid leukocyte differentiation." [GOC:add] synonym: "activation of myeloid leukocyte differentiation" NARROW [] synonym: "stimulation of myeloid leukocyte differentiation" NARROW [] synonym: "up regulation of myeloid leukocyte differentiation" EXACT [] synonym: "up-regulation of myeloid leukocyte differentiation" EXACT [] synonym: "upregulation of myeloid leukocyte differentiation" EXACT [] is_a: GO:0002761 ! regulation of myeloid leukocyte differentiation is_a: GO:0045639 ! positive regulation of myeloid cell differentiation is_a: GO:1902107 ! positive regulation of leukocyte differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0002573 ! positively regulates myeloid leukocyte differentiation relationship: RO:0002213 GO:0002573 ! positively regulates myeloid leukocyte differentiation [Term] id: GO:0002775 name: antimicrobial peptide production namespace: biological_process def: "The synthesis or release of an antimicrobial peptide during an immune response, resulting in an increase in intracellular or extracellular levels. Such peptides may have protective properties against bacteria, fungi, viruses, or protozoa." [GOC:add, ISBN:0781735149, PMID:11807545, PMID:15638771] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms. subset: gocheck_do_not_annotate is_a: GO:0002440 ! production of molecular mediator of immune response relationship: BFO:0000050 GO:0061844 ! part of antimicrobial humoral immune response mediated by antimicrobial peptide property_value: RO:0002161 NCBITaxon:4895 [Term] id: GO:0002776 name: antimicrobial peptide secretion namespace: biological_process def: "The regulated release of an antimicrobial peptide from a cell or a tissue. Such peptides may have protective properties against bacteria, fungi, viruses, or protozoa." [GOC:add, ISBN:0781735149, PMID:11807545, PMID:15638771] is_a: GO:0002790 ! peptide secretion relationship: BFO:0000050 GO:0002775 ! part of antimicrobial peptide production property_value: RO:0002161 NCBITaxon:4895 [Term] id: GO:0002784 name: regulation of antimicrobial peptide production namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of antimicrobial peptide production." [GOC:add] is_a: GO:0002700 ! regulation of production of molecular mediator of immune response is_a: GO:0002759 ! regulation of antimicrobial humoral response intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0002775 ! regulates antimicrobial peptide production relationship: RO:0002211 GO:0002775 ! regulates antimicrobial peptide production property_value: RO:0002161 NCBITaxon:4895 [Term] id: GO:0002785 name: negative regulation of antimicrobial peptide production namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of antimicrobial peptide production." [GOC:add] synonym: "down regulation of antimicrobial peptide production" EXACT [] synonym: "down-regulation of antimicrobial peptide production" EXACT [] synonym: "downregulation of antimicrobial peptide production" EXACT [] synonym: "inhibition of antimicrobial peptide production" NARROW [] is_a: GO:0002701 ! negative regulation of production of molecular mediator of immune response is_a: GO:0002784 ! regulation of antimicrobial peptide production is_a: GO:0008348 ! negative regulation of antimicrobial humoral response intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0002775 ! negatively regulates antimicrobial peptide production relationship: RO:0002212 GO:0002775 ! negatively regulates antimicrobial peptide production property_value: RO:0002161 NCBITaxon:4895 [Term] id: GO:0002790 name: peptide secretion namespace: biological_process def: "The controlled release of a peptide from a cell or a tissue." [GOC:add] is_a: GO:0015833 ! peptide transport is_a: GO:0046903 ! secretion intersection_of: GO:0046903 ! secretion intersection_of: RO:0004009 CHEBI:60466 ! has primary input [Term] id: GO:0002791 name: regulation of peptide secretion namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of peptide secretion." [GOC:add] is_a: GO:0051046 ! regulation of secretion is_a: GO:0090087 ! regulation of peptide transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0002790 ! regulates peptide secretion relationship: RO:0002211 GO:0002790 ! regulates peptide secretion [Term] id: GO:0002792 name: negative regulation of peptide secretion namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of peptide secretion." [GOC:add] synonym: "down regulation of peptide secretion" EXACT [] synonym: "down-regulation of peptide secretion" EXACT [] synonym: "downregulation of peptide secretion" EXACT [] synonym: "inhibition of peptide secretion" NARROW [] is_a: GO:0002791 ! regulation of peptide secretion is_a: GO:0051048 ! negative regulation of secretion intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0002790 ! negatively regulates peptide secretion relationship: RO:0002212 GO:0002790 ! negatively regulates peptide secretion [Term] id: GO:0002793 name: positive regulation of peptide secretion namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of peptide secretion." [GOC:add] synonym: "activation of peptide secretion" NARROW [] synonym: "stimulation of peptide secretion" NARROW [] synonym: "up regulation of peptide secretion" EXACT [] synonym: "up-regulation of peptide secretion" EXACT [] synonym: "upregulation of peptide secretion" EXACT [] is_a: GO:0002791 ! regulation of peptide secretion is_a: GO:0051047 ! positive regulation of secretion intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0002790 ! positively regulates peptide secretion relationship: RO:0002213 GO:0002790 ! positively regulates peptide secretion [Term] id: GO:0002794 name: regulation of antimicrobial peptide secretion namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of antimicrobial peptide secretion." [GOC:add] is_a: GO:0002784 ! regulation of antimicrobial peptide production is_a: GO:0002791 ! regulation of peptide secretion intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0002776 ! regulates antimicrobial peptide secretion relationship: RO:0002211 GO:0002776 ! regulates antimicrobial peptide secretion property_value: RO:0002161 NCBITaxon:4895 [Term] id: GO:0002795 name: negative regulation of antimicrobial peptide secretion namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of antimicrobial peptide secretion." [GOC:add] synonym: "down regulation of antimicrobial peptide secretion" EXACT [] synonym: "down-regulation of antimicrobial peptide secretion" EXACT [] synonym: "downregulation of antimicrobial peptide secretion" EXACT [] synonym: "inhibition of antimicrobial peptide secretion" NARROW [] is_a: GO:0002785 ! negative regulation of antimicrobial peptide production is_a: GO:0002792 ! negative regulation of peptide secretion is_a: GO:0002794 ! regulation of antimicrobial peptide secretion intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0002776 ! negatively regulates antimicrobial peptide secretion relationship: RO:0002212 GO:0002776 ! negatively regulates antimicrobial peptide secretion property_value: RO:0002161 NCBITaxon:4895 [Term] id: GO:0002796 name: positive regulation of antimicrobial peptide secretion namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of antimicrobial peptide secretion." [GOC:add] synonym: "activation of antimicrobial peptide secretion" NARROW [] synonym: "stimulation of antimicrobial peptide secretion" NARROW [] synonym: "up regulation of antimicrobial peptide secretion" EXACT [] synonym: "up-regulation of antimicrobial peptide secretion" EXACT [] synonym: "upregulation of antimicrobial peptide secretion" EXACT [] is_a: GO:0002225 ! positive regulation of antimicrobial peptide production is_a: GO:0002793 ! positive regulation of peptide secretion is_a: GO:0002794 ! regulation of antimicrobial peptide secretion intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0002776 ! positively regulates antimicrobial peptide secretion relationship: RO:0002213 GO:0002776 ! positively regulates antimicrobial peptide secretion property_value: RO:0002161 NCBITaxon:4895 [Term] id: GO:0002819 name: regulation of adaptive immune response namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of an adaptive immune response." [GOC:add] is_a: GO:0050776 ! regulation of immune response intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0002250 ! regulates adaptive immune response relationship: RO:0002211 GO:0002250 ! regulates adaptive immune response [Term] id: GO:0002820 name: negative regulation of adaptive immune response namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of an adaptive immune response." [GOC:add] synonym: "down regulation of adaptive immune response" EXACT [] synonym: "down-regulation of adaptive immune response" EXACT [] synonym: "downregulation of adaptive immune response" EXACT [] synonym: "inhibition of adaptive immune response" NARROW [] is_a: GO:0002819 ! regulation of adaptive immune response is_a: GO:0050777 ! negative regulation of immune response intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0002250 ! negatively regulates adaptive immune response relationship: RO:0002212 GO:0002250 ! negatively regulates adaptive immune response [Term] id: GO:0002821 name: positive regulation of adaptive immune response namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of an adaptive immune response." [GOC:add] synonym: "activation of adaptive immune response" NARROW [] synonym: "stimulation of adaptive immune response" NARROW [] synonym: "up regulation of adaptive immune response" EXACT [] synonym: "up-regulation of adaptive immune response" EXACT [] synonym: "upregulation of adaptive immune response" EXACT [] is_a: GO:0002819 ! regulation of adaptive immune response is_a: GO:0050778 ! positive regulation of immune response intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0002250 ! positively regulates adaptive immune response relationship: RO:0002213 GO:0002250 ! positively regulates adaptive immune response [Term] id: GO:0002822 name: regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of an adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains. An example of this process is found in the Gnathostomata." [GOC:add, GOC:mtg_sensu] is_a: GO:0002819 ! regulation of adaptive immune response intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0002460 ! regulates adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains relationship: RO:0002162 NCBITaxon:7776 ! in taxon Gnathostomata relationship: RO:0002211 GO:0002460 ! regulates adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [Term] id: GO:0002823 name: negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of an adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains. An example of this process is found in the Gnathostomata." [GOC:add, GOC:mtg_sensu] is_a: GO:0002820 ! negative regulation of adaptive immune response is_a: GO:0002822 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0002460 ! negatively regulates adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains relationship: RO:0002212 GO:0002460 ! negatively regulates adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [Term] id: GO:0002824 name: positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of an adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains. An example of this process is found in the Gnathostomata." [GOC:add, GOC:mtg_sensu] is_a: GO:0002821 ! positive regulation of adaptive immune response is_a: GO:0002822 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0002460 ! positively regulates adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains relationship: RO:0002213 GO:0002460 ! positively regulates adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [Term] id: GO:0002825 name: regulation of T-helper 1 type immune response namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of a T-helper 1 type immune response." [GOC:add] is_a: GO:0002822 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0042088 ! regulates T-helper 1 type immune response relationship: RO:0002211 GO:0042088 ! regulates T-helper 1 type immune response [Term] id: GO:0002826 name: negative regulation of T-helper 1 type immune response namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of a T-helper 1 type immune response." [GOC:add] synonym: "down regulation of T-helper 1 type immune response" EXACT [] synonym: "down-regulation of T-helper 1 type immune response" EXACT [] synonym: "downregulation of T-helper 1 type immune response" EXACT [] synonym: "inhibition of T-helper 1 type immune response" NARROW [] is_a: GO:0002823 ! negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains is_a: GO:0002825 ! regulation of T-helper 1 type immune response intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0042088 ! negatively regulates T-helper 1 type immune response relationship: RO:0002212 GO:0042088 ! negatively regulates T-helper 1 type immune response [Term] id: GO:0002827 name: positive regulation of T-helper 1 type immune response namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of a T-helper 1 type immune response." [GOC:add] synonym: "activation of T-helper 1 type immune response" NARROW [] synonym: "stimulation of T-helper 1 type immune response" NARROW [] synonym: "up regulation of T-helper 1 type immune response" EXACT [] synonym: "up-regulation of T-helper 1 type immune response" EXACT [] synonym: "upregulation of T-helper 1 type immune response" EXACT [] is_a: GO:0002824 ! positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains is_a: GO:0002825 ! regulation of T-helper 1 type immune response intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0042088 ! positively regulates T-helper 1 type immune response relationship: RO:0002213 GO:0042088 ! positively regulates T-helper 1 type immune response [Term] id: GO:0002828 name: regulation of type 2 immune response namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of a type 2 immune response." [GOC:add] synonym: "regulation of T-helper 2 type immune response" NARROW [GOC:add] synonym: "regulation of Th2 immune response" NARROW [GOC:add] is_a: GO:0050776 ! regulation of immune response intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0042092 ! regulates type 2 immune response relationship: RO:0002211 GO:0042092 ! regulates type 2 immune response property_value: RO:0002161 NCBITaxon:4895 [Term] id: GO:0002829 name: negative regulation of type 2 immune response namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of a type 2 immune response." [GOC:add] synonym: "down regulation of type 2 immune response" EXACT [] synonym: "down-regulation of type 2 immune response" EXACT [] synonym: "downregulation of type 2 immune response" EXACT [] synonym: "inhibition of type 2 immune response" NARROW [] synonym: "negative regulation of T-helper 2 type immune response" NARROW [GOC:add] synonym: "negative regulation of Th2 immune response" NARROW [GOC:add] is_a: GO:0002828 ! regulation of type 2 immune response is_a: GO:0050777 ! negative regulation of immune response intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0042092 ! negatively regulates type 2 immune response relationship: RO:0002212 GO:0042092 ! negatively regulates type 2 immune response property_value: RO:0002161 NCBITaxon:4895 [Term] id: GO:0002830 name: positive regulation of type 2 immune response namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of a type 2 immune response." [GOC:add] synonym: "activation of type 2 immune response" NARROW [] synonym: "positive regulation of T-helper 2 type immune response" NARROW [GOC:add] synonym: "positive regulation of Th2 immune response" NARROW [GOC:add] synonym: "stimulation of type 2 immune response" NARROW [] synonym: "up regulation of type 2 immune response" EXACT [] synonym: "up-regulation of type 2 immune response" EXACT [] synonym: "upregulation of type 2 immune response" EXACT [] is_a: GO:0002828 ! regulation of type 2 immune response is_a: GO:0050778 ! positive regulation of immune response intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0042092 ! positively regulates type 2 immune response relationship: RO:0002213 GO:0042092 ! positively regulates type 2 immune response property_value: RO:0002161 NCBITaxon:4895 [Term] id: GO:0002831 name: regulation of response to biotic stimulus namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of a response to biotic stimulus." [GOC:add] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_annotate is_a: GO:0048583 ! regulation of response to stimulus intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0009607 ! regulates response to biotic stimulus relationship: RO:0002211 GO:0009607 ! regulates response to biotic stimulus [Term] id: GO:0002832 name: negative regulation of response to biotic stimulus namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of a response to biotic stimulus." [GOC:add] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_annotate synonym: "down regulation of response to biotic stimulus" EXACT [] synonym: "down-regulation of response to biotic stimulus" EXACT [] synonym: "downregulation of response to biotic stimulus" EXACT [] synonym: "inhibition of response to biotic stimulus" NARROW [] is_a: GO:0002831 ! regulation of response to biotic stimulus is_a: GO:0048585 ! negative regulation of response to stimulus intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0009607 ! negatively regulates response to biotic stimulus relationship: RO:0002212 GO:0009607 ! negatively regulates response to biotic stimulus [Term] id: GO:0002833 name: positive regulation of response to biotic stimulus namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of a response to biotic stimulus." [GOC:add] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_annotate synonym: "activation of response to biotic stimulus" NARROW [] synonym: "stimulation of response to biotic stimulus" NARROW [] synonym: "up regulation of response to biotic stimulus" EXACT [] synonym: "up-regulation of response to biotic stimulus" EXACT [] synonym: "upregulation of response to biotic stimulus" EXACT [] is_a: GO:0002831 ! regulation of response to biotic stimulus is_a: GO:0048584 ! positive regulation of response to stimulus intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0009607 ! positively regulates response to biotic stimulus relationship: RO:0002213 GO:0009607 ! positively regulates response to biotic stimulus [Term] id: GO:0002849 name: regulation of peripheral T cell tolerance induction namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of peripheral T cell tolerance induction." [GOC:add] is_a: GO:0002658 ! regulation of peripheral tolerance induction is_a: GO:0002664 ! regulation of T cell tolerance induction is_a: GO:0002709 ! regulation of T cell mediated immunity intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0002458 ! regulates peripheral T cell tolerance induction relationship: RO:0002211 GO:0002458 ! regulates peripheral T cell tolerance induction [Term] id: GO:0002850 name: negative regulation of peripheral T cell tolerance induction namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of peripheral T cell tolerance induction." [GOC:add] synonym: "down regulation of peripheral T cell tolerance induction" EXACT [] synonym: "down-regulation of peripheral T cell tolerance induction" EXACT [] synonym: "downregulation of peripheral T cell tolerance induction" EXACT [] synonym: "inhibition of peripheral T cell tolerance induction" NARROW [] is_a: GO:0002659 ! negative regulation of peripheral tolerance induction is_a: GO:0002665 ! negative regulation of T cell tolerance induction is_a: GO:0002710 ! negative regulation of T cell mediated immunity is_a: GO:0002849 ! regulation of peripheral T cell tolerance induction intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0002458 ! negatively regulates peripheral T cell tolerance induction relationship: RO:0002212 GO:0002458 ! negatively regulates peripheral T cell tolerance induction [Term] id: GO:0002851 name: positive regulation of peripheral T cell tolerance induction namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of peripheral T cell tolerance induction." [GOC:add] synonym: "activation of peripheral T cell tolerance induction" NARROW [] synonym: "stimulation of peripheral T cell tolerance induction" NARROW [] synonym: "up regulation of peripheral T cell tolerance induction" EXACT [] synonym: "up-regulation of peripheral T cell tolerance induction" EXACT [] synonym: "upregulation of peripheral T cell tolerance induction" EXACT [] is_a: GO:0002660 ! positive regulation of peripheral tolerance induction is_a: GO:0002666 ! positive regulation of T cell tolerance induction is_a: GO:0002711 ! positive regulation of T cell mediated immunity is_a: GO:0002849 ! regulation of peripheral T cell tolerance induction intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0002458 ! positively regulates peripheral T cell tolerance induction relationship: RO:0002213 GO:0002458 ! positively regulates peripheral T cell tolerance induction [Term] id: GO:0002867 name: regulation of B cell deletion namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of B cell deletion." [GOC:add] synonym: "regulation of B lymphocyte deletion" EXACT [] synonym: "regulation of B-cell deletion" EXACT [] synonym: "regulation of B-lymphocyte deletion" EXACT [] is_a: GO:0002661 ! regulation of B cell tolerance induction is_a: GO:0002902 ! regulation of B cell apoptotic process is_a: GO:1904748 ! regulation of apoptotic process involved in development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0002516 ! regulates B cell deletion relationship: RO:0002211 GO:0002516 ! regulates B cell deletion [Term] id: GO:0002868 name: negative regulation of B cell deletion namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of B cell deletion." [GOC:add] synonym: "down regulation of B cell deletion" EXACT [] synonym: "down-regulation of B cell deletion" EXACT [] synonym: "downregulation of B cell deletion" EXACT [] synonym: "inhibition of B cell deletion" NARROW [] synonym: "negative regulation of B lymphocyte deletion" EXACT [] synonym: "negative regulation of B-cell deletion" EXACT [] synonym: "negative regulation of B-lymphocyte deletion" EXACT [] is_a: GO:0002662 ! negative regulation of B cell tolerance induction is_a: GO:0002673 ! regulation of acute inflammatory response is_a: GO:0002867 ! regulation of B cell deletion is_a: GO:0002903 ! negative regulation of B cell apoptotic process is_a: GO:1904746 ! negative regulation of apoptotic process involved in development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0002516 ! negatively regulates B cell deletion relationship: RO:0002212 GO:0002516 ! negatively regulates B cell deletion [Term] id: GO:0002869 name: positive regulation of B cell deletion namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of B cell deletion." [GOC:add] synonym: "activation of B cell deletion" NARROW [] synonym: "positive regulation of B lymphocyte deletion" EXACT [] synonym: "positive regulation of B-cell deletion" EXACT [] synonym: "positive regulation of B-lymphocyte deletion" EXACT [] synonym: "stimulation of B cell deletion" NARROW [] synonym: "up regulation of B cell deletion" EXACT [] synonym: "up-regulation of B cell deletion" EXACT [] synonym: "upregulation of B cell deletion" EXACT [] is_a: GO:0002663 ! positive regulation of B cell tolerance induction is_a: GO:0002673 ! regulation of acute inflammatory response is_a: GO:0002867 ! regulation of B cell deletion is_a: GO:0002904 ! positive regulation of B cell apoptotic process is_a: GO:1904747 ! positive regulation of apoptotic process involved in development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0002516 ! positively regulates B cell deletion relationship: RO:0002213 GO:0002516 ! positively regulates B cell deletion [Term] id: GO:0002870 name: T cell anergy namespace: biological_process def: "Any process contributing to anergy in T cells, a state of functional inactivation which is part of T cell tolerance induction." [GOC:add, ISBN:0781735149] synonym: "T lymphocyte anergy" EXACT [] synonym: "T-cell anergy" EXACT [] synonym: "T-lymphocyte anergy" EXACT [] is_a: GO:0002249 ! lymphocyte anergy is_a: GO:0002517 ! T cell tolerance induction intersection_of: GO:0002249 ! lymphocyte anergy intersection_of: RO:0004009 CL:0000084 ! has primary input T cell relationship: RO:0004009 CL:0000084 ! has primary input T cell property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4895 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0002871 name: regulation of natural killer cell tolerance induction namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of natural killer cell tolerance induction." [GOC:add] synonym: "regulation of NK cell tolerance induction" EXACT [] is_a: GO:0002643 ! regulation of tolerance induction intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0002519 ! regulates natural killer cell tolerance induction relationship: RO:0002211 GO:0002519 ! regulates natural killer cell tolerance induction property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4895 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0002872 name: negative regulation of natural killer cell tolerance induction namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of natural killer cell tolerance induction." [GOC:add] synonym: "down regulation of natural killer cell tolerance induction" EXACT [] synonym: "down-regulation of natural killer cell tolerance induction" EXACT [] synonym: "downregulation of natural killer cell tolerance induction" EXACT [] synonym: "inhibition of natural killer cell tolerance induction" NARROW [] synonym: "negative regulation of NK cell tolerance induction" EXACT [] is_a: GO:0002644 ! negative regulation of tolerance induction is_a: GO:0002673 ! regulation of acute inflammatory response is_a: GO:0002871 ! regulation of natural killer cell tolerance induction intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0002519 ! negatively regulates natural killer cell tolerance induction relationship: RO:0002212 GO:0002519 ! negatively regulates natural killer cell tolerance induction [Term] id: GO:0002873 name: positive regulation of natural killer cell tolerance induction namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of natural killer cell tolerance induction." [GOC:add] synonym: "activation of natural killer cell tolerance induction" NARROW [] synonym: "positive regulation of NK cell tolerance induction" EXACT [] synonym: "stimulation of natural killer cell tolerance induction" NARROW [] synonym: "up regulation of natural killer cell tolerance induction" EXACT [] synonym: "up-regulation of natural killer cell tolerance induction" EXACT [] synonym: "upregulation of natural killer cell tolerance induction" EXACT [] is_a: GO:0002645 ! positive regulation of tolerance induction is_a: GO:0002673 ! regulation of acute inflammatory response is_a: GO:0002871 ! regulation of natural killer cell tolerance induction intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0002519 ! positively regulates natural killer cell tolerance induction relationship: RO:0002213 GO:0002519 ! positively regulates natural killer cell tolerance induction [Term] id: GO:0002886 name: regulation of myeloid leukocyte mediated immunity namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of myeloid leukocyte mediated immunity." [GOC:add] is_a: GO:0002703 ! regulation of leukocyte mediated immunity intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0002444 ! regulates myeloid leukocyte mediated immunity relationship: RO:0002211 GO:0002444 ! regulates myeloid leukocyte mediated immunity [Term] id: GO:0002887 name: negative regulation of myeloid leukocyte mediated immunity namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of myeloid leukocyte mediated immunity." [GOC:add] synonym: "down regulation of myeloid leukocyte mediated immunity" EXACT [] synonym: "down-regulation of myeloid leukocyte mediated immunity" EXACT [] synonym: "downregulation of myeloid leukocyte mediated immunity" EXACT [] synonym: "inhibition of myeloid leukocyte mediated immunity" NARROW [] is_a: GO:0002704 ! negative regulation of leukocyte mediated immunity is_a: GO:0002886 ! regulation of myeloid leukocyte mediated immunity intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0002444 ! negatively regulates myeloid leukocyte mediated immunity relationship: RO:0002212 GO:0002444 ! negatively regulates myeloid leukocyte mediated immunity [Term] id: GO:0002888 name: positive regulation of myeloid leukocyte mediated immunity namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of myeloid leukocyte mediated immunity." [GOC:add] synonym: "activation of myeloid leukocyte mediated immunity" NARROW [] synonym: "stimulation of myeloid leukocyte mediated immunity" NARROW [] synonym: "up regulation of myeloid leukocyte mediated immunity" EXACT [] synonym: "up-regulation of myeloid leukocyte mediated immunity" EXACT [] synonym: "upregulation of myeloid leukocyte mediated immunity" EXACT [] is_a: GO:0002705 ! positive regulation of leukocyte mediated immunity is_a: GO:0002886 ! regulation of myeloid leukocyte mediated immunity intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0002444 ! positively regulates myeloid leukocyte mediated immunity relationship: RO:0002213 GO:0002444 ! positively regulates myeloid leukocyte mediated immunity [Term] id: GO:0002889 name: regulation of immunoglobulin mediated immune response namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of an immunoglobulin mediated immune response." [GOC:add] is_a: GO:0002712 ! regulation of B cell mediated immunity intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0016064 ! regulates immunoglobulin mediated immune response relationship: RO:0002211 GO:0016064 ! regulates immunoglobulin mediated immune response [Term] id: GO:0002890 name: negative regulation of immunoglobulin mediated immune response namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of an immunoglobulin mediated immune response." [GOC:add] synonym: "down regulation of immunoglobulin mediated immune response" EXACT [] synonym: "down-regulation of immunoglobulin mediated immune response" EXACT [] synonym: "downregulation of immunoglobulin mediated immune response" EXACT [] synonym: "inhibition of immunoglobulin mediated immune response" NARROW [] is_a: GO:0002713 ! negative regulation of B cell mediated immunity is_a: GO:0002889 ! regulation of immunoglobulin mediated immune response intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0016064 ! negatively regulates immunoglobulin mediated immune response relationship: RO:0002212 GO:0016064 ! negatively regulates immunoglobulin mediated immune response [Term] id: GO:0002891 name: positive regulation of immunoglobulin mediated immune response namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of an immunoglobulin mediated immune response." [GOC:add] synonym: "activation of immunoglobulin mediated immune response" NARROW [] synonym: "stimulation of immunoglobulin mediated immune response" NARROW [] synonym: "up regulation of immunoglobulin mediated immune response" EXACT [] synonym: "up-regulation of immunoglobulin mediated immune response" EXACT [] synonym: "upregulation of immunoglobulin mediated immune response" EXACT [] is_a: GO:0002714 ! positive regulation of B cell mediated immunity is_a: GO:0002889 ! regulation of immunoglobulin mediated immune response intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0016064 ! positively regulates immunoglobulin mediated immune response relationship: RO:0002213 GO:0016064 ! positively regulates immunoglobulin mediated immune response [Term] id: GO:0002901 name: mature B cell apoptotic process namespace: biological_process def: "Any apoptotic process in a B cell that is mature, having left the bone marrow." [CL:0000785, GOC:add, GOC:mtg_apoptosis, ISBN:0781735149] synonym: "apoptosis of mature B cells" EXACT [] synonym: "apoptosis of mature B lymphocytes" EXACT [] synonym: "apoptosis of mature B-cells" EXACT [] synonym: "apoptosis of mature B-lymphocytes" EXACT [] synonym: "mature B cell apoptosis" NARROW [] synonym: "mature B cell programmed cell death by apoptosis" EXACT [] synonym: "mature B lymphocyte apoptosis" EXACT [] synonym: "mature B lymphocyte programmed cell death by apoptosis" EXACT [] synonym: "mature B-cell apoptosis" EXACT [] synonym: "mature B-cell programmed cell death by apoptosis" EXACT [] synonym: "mature B-lymphocyte apoptosis" EXACT [] synonym: "mature B-lymphocyte programmed cell death by apoptosis" EXACT [] synonym: "programmed cell death of mature B cells by apoptosis" EXACT [] synonym: "programmed cell death of mature B lymphocytes by apoptosis" EXACT [] synonym: "programmed cell death of mature B-cells by apoptosis" EXACT [] synonym: "programmed cell death of mature B-lymphocytes by apoptosis" EXACT [] synonym: "programmed cell death, mature B cells" EXACT [] synonym: "programmed cell death, mature B lymphocytes" EXACT [] synonym: "programmed cell death, mature B-cells" EXACT [] synonym: "programmed cell death, mature B-lymphocytes" EXACT [] is_a: GO:0001783 ! B cell apoptotic process intersection_of: GO:0006915 ! apoptotic process intersection_of: BFO:0000066 CL:0000785 ! occurs in mature B cell relationship: BFO:0000050 GO:0001782 ! part of B cell homeostasis relationship: BFO:0000066 CL:0000785 ! occurs in mature B cell [Term] id: GO:0002902 name: regulation of B cell apoptotic process namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of B cell apoptotic process." [GOC:add, GOC:mtg_apoptosis] synonym: "regulation of B cell apoptosis" NARROW [] is_a: GO:0070228 ! regulation of lymphocyte apoptotic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0001783 ! regulates B cell apoptotic process relationship: RO:0002211 GO:0001783 ! regulates B cell apoptotic process [Term] id: GO:0002903 name: negative regulation of B cell apoptotic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of B cell apoptotic process." [GOC:add, GOC:mtg_apoptosis] synonym: "down regulation of B cell apoptosis" EXACT [] synonym: "down-regulation of B cell apoptosis" EXACT [] synonym: "downregulation of B cell apoptosis" EXACT [] synonym: "inhibition of B cell apoptosis" NARROW [] synonym: "negative regulation of B cell apoptosis" NARROW [] is_a: GO:0002902 ! regulation of B cell apoptotic process is_a: GO:0070229 ! negative regulation of lymphocyte apoptotic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0001783 ! negatively regulates B cell apoptotic process relationship: RO:0002212 GO:0001783 ! negatively regulates B cell apoptotic process [Term] id: GO:0002904 name: positive regulation of B cell apoptotic process namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of B cell apoptotic process." [GOC:add, GOC:mtg_apoptosis] synonym: "activation of B cell apoptosis" NARROW [] synonym: "positive regulation of B cell apoptosis" NARROW [] synonym: "stimulation of B cell apoptosis" NARROW [] synonym: "up regulation of B cell apoptosis" EXACT [] synonym: "up-regulation of B cell apoptosis" EXACT [] synonym: "upregulation of B cell apoptosis" EXACT [] is_a: GO:0002902 ! regulation of B cell apoptotic process is_a: GO:0070230 ! positive regulation of lymphocyte apoptotic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0001783 ! positively regulates B cell apoptotic process relationship: RO:0002213 GO:0001783 ! positively regulates B cell apoptotic process [Term] id: GO:0002905 name: regulation of mature B cell apoptotic process namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of mature B cell apoptotic process." [GOC:add, GOC:mtg_apoptosis] synonym: "regulation of mature B cell apoptosis" NARROW [] is_a: GO:0002682 ! regulation of immune system process is_a: GO:0002902 ! regulation of B cell apoptotic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0002901 ! regulates mature B cell apoptotic process relationship: RO:0002211 GO:0002901 ! regulates mature B cell apoptotic process [Term] id: GO:0002906 name: negative regulation of mature B cell apoptotic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of mature B cell apoptotic process." [GOC:add, GOC:mtg_apoptosis] synonym: "down regulation of mature B cell apoptosis" EXACT [] synonym: "down-regulation of mature B cell apoptosis" EXACT [] synonym: "downregulation of mature B cell apoptosis" EXACT [] synonym: "inhibition of mature B cell apoptosis" NARROW [] synonym: "negative regulation of mature B cell apoptosis" NARROW [] is_a: GO:0002903 ! negative regulation of B cell apoptotic process is_a: GO:0002905 ! regulation of mature B cell apoptotic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0002901 ! negatively regulates mature B cell apoptotic process relationship: RO:0002212 GO:0002901 ! negatively regulates mature B cell apoptotic process [Term] id: GO:0002907 name: positive regulation of mature B cell apoptotic process namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of mature B cell apoptotic process." [GOC:add, GOC:mtg_apoptosis] synonym: "activation of mature B cell apoptosis" NARROW [] synonym: "positive regulation of mature B cell apoptosis" NARROW [] synonym: "stimulation of mature B cell apoptosis" NARROW [] synonym: "up regulation of mature B cell apoptosis" EXACT [] synonym: "up-regulation of mature B cell apoptosis" EXACT [] synonym: "upregulation of mature B cell apoptosis" EXACT [] is_a: GO:0002684 ! positive regulation of immune system process is_a: GO:0002904 ! positive regulation of B cell apoptotic process is_a: GO:0002905 ! regulation of mature B cell apoptotic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0002901 ! positively regulates mature B cell apoptotic process relationship: RO:0002213 GO:0002901 ! positively regulates mature B cell apoptotic process [Term] id: GO:0002911 name: regulation of lymphocyte anergy namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of lymphocyte anergy." [GOC:add] is_a: GO:0002643 ! regulation of tolerance induction intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0002249 ! regulates lymphocyte anergy relationship: RO:0002211 GO:0002249 ! regulates lymphocyte anergy property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4895 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0002912 name: negative regulation of lymphocyte anergy namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of lymphocyte anergy." [GOC:add] synonym: "down regulation of lymphocyte anergy" EXACT [] synonym: "down-regulation of lymphocyte anergy" EXACT [] synonym: "downregulation of lymphocyte anergy" EXACT [] synonym: "inhibition of lymphocyte anergy" NARROW [] is_a: GO:0002644 ! negative regulation of tolerance induction is_a: GO:0002911 ! regulation of lymphocyte anergy intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0002249 ! negatively regulates lymphocyte anergy relationship: RO:0002212 GO:0002249 ! negatively regulates lymphocyte anergy property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4895 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0002913 name: positive regulation of lymphocyte anergy namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of lymphocyte anergy." [GOC:add] synonym: "activation of lymphocyte anergy" NARROW [] synonym: "stimulation of lymphocyte anergy" NARROW [] synonym: "up regulation of lymphocyte anergy" EXACT [] synonym: "up-regulation of lymphocyte anergy" EXACT [] synonym: "upregulation of lymphocyte anergy" EXACT [] is_a: GO:0002645 ! positive regulation of tolerance induction is_a: GO:0002911 ! regulation of lymphocyte anergy intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0002249 ! positively regulates lymphocyte anergy relationship: RO:0002213 GO:0002249 ! positively regulates lymphocyte anergy property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4895 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0002920 name: regulation of humoral immune response namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of a humoral immune response." [GOC:add] is_a: GO:0050776 ! regulation of immune response intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0006959 ! regulates humoral immune response relationship: RO:0002211 GO:0006959 ! regulates humoral immune response property_value: RO:0002161 NCBITaxon:4895 [Term] id: GO:0002921 name: negative regulation of humoral immune response namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of a humoral immune response." [GOC:add] synonym: "down regulation of humoral immune response" EXACT [] synonym: "down-regulation of humoral immune response" EXACT [] synonym: "downregulation of humoral immune response" EXACT [] synonym: "inhibition of humoral immune response" NARROW [] is_a: GO:0002920 ! regulation of humoral immune response is_a: GO:0050777 ! negative regulation of immune response intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0006959 ! negatively regulates humoral immune response relationship: RO:0002212 GO:0006959 ! negatively regulates humoral immune response property_value: RO:0002161 NCBITaxon:4895 [Term] id: GO:0002922 name: positive regulation of humoral immune response namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of a humoral immune response." [GOC:add] synonym: "activation of humoral immune response" NARROW [] synonym: "stimulation of humoral immune response" NARROW [] synonym: "up regulation of humoral immune response" EXACT [] synonym: "up-regulation of humoral immune response" EXACT [] synonym: "upregulation of humoral immune response" EXACT [] is_a: GO:0002920 ! regulation of humoral immune response is_a: GO:0050778 ! positive regulation of immune response intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0006959 ! positively regulates humoral immune response relationship: RO:0002213 GO:0006959 ! positively regulates humoral immune response property_value: RO:0002161 NCBITaxon:4895 [Term] id: GO:0002930 name: trabecular meshwork development namespace: biological_process def: "The progression of the trabecular meshwork over time, from its formation to the mature structure. The trabecular meshwork is a fenestrated endothelial-like tissue situated at the intersection of the cornea and the iris. The trabecular meshwork provides drainage for the aqueous humor." [PMID:20568247] is_a: GO:0009888 ! tissue development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0005969 ! results in development of eye trabecular meshwork relationship: BFO:0000050 GO:0043010 ! part of camera-type eye development relationship: RO:0002296 UBERON:0005969 ! results in development of eye trabecular meshwork creation_date: 2012-04-19T04:50:06Z [Term] id: GO:0002932 name: tendon sheath development namespace: biological_process def: "The process whose specific outcome is the progression of a tendon sheath over time, from its formation to the mature structure. A tendon sheath is a layer of membrane around a tendon. It permits the tendon to move." [PMID:20696843] is_a: GO:0061448 ! connective tissue development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0000304 ! results in development of tendon sheath relationship: BFO:0000050 GO:0035989 ! part of tendon development relationship: RO:0002296 UBERON:0000304 ! results in development of tendon sheath creation_date: 2012-04-23T02:11:22Z [Term] id: GO:0002934 name: desmosome organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a desmosome. A desmosome is a patch-like intercellular junction found in vertebrate tissues, consisting of parallel zones of two cell membranes, separated by an space of 25-35 nm, and having dense fibrillar plaques in the subjacent cytoplasm." [GOC:hjd] is_a: GO:0045216 ! cell-cell junction organization intersection_of: GO:0016043 ! cellular component organization intersection_of: RO:0002592 GO:0030057 ! results in organization of desmosome relationship: RO:0002592 GO:0030057 ! results in organization of desmosome creation_date: 2012-05-08T02:59:08Z [Term] id: GO:0002941 name: synoviocyte proliferation namespace: biological_process def: "The multiplication or reproduction of type B synoviocytes by cell division, resulting in the expansion of their population. A type B synoviocyte is a fibroblast-like cell found in synovial tissues." [PMID:10770586, PMID:9546370] is_a: GO:0050673 ! epithelial cell proliferation intersection_of: GO:0008283 ! cell population proliferation intersection_of: RO:0012003 CL:0002301 ! acts on population of type B synovial cell relationship: RO:0012003 CL:0002301 ! acts on population of type B synovial cell property_value: RO:0002161 NCBITaxon:4751 creation_date: 2012-11-16T14:25:45Z [Term] id: GO:0003002 name: regionalization namespace: biological_process def: "The pattern specification process that results in the subdivision of an axis or axes in space to define an area or volume in which specific patterns of cell differentiation will take place or in which cells interpret a specific environment." [GOC:dph, GOC:isa_complete] synonym: "pattern formation" RELATED [GOC:dph] is_a: GO:0007389 ! pattern specification process property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0003006 name: developmental process involved in reproduction namespace: biological_process def: "A developmental process in which a progressive change in the state of some part of an organism, germline or somatic, specifically contributes to its ability to form offspring." [GOC:dph, GOC:isa_complete] synonym: "puberty" NARROW [GOC:dph] synonym: "reproductive developmental process" RELATED [GOC:dph, GOC:tb] is_a: GO:0022414 ! reproductive process is_a: GO:0032502 ! developmental process intersection_of: GO:0022414 ! reproductive process intersection_of: GO:0032502 ! developmental process [Term] id: GO:0003007 name: heart morphogenesis namespace: biological_process def: "The developmental process in which the heart is generated and organized. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood." [GOC:dph, GOC:isa_complete] synonym: "cardiac morphogenesis" RELATED [] is_a: GO:0009887 ! animal organ morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0007100 ! results in morphogenesis of primary circulatory organ relationship: BFO:0000050 GO:0007507 ! part of heart development relationship: RO:0002298 UBERON:0007100 ! results in morphogenesis of primary circulatory organ [Term] id: GO:0003008 name: system process namespace: biological_process def: "A multicellular organismal process carried out by any of the organs or tissues in an organ system. An organ system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a biological objective." [GOC:mtg_cardio] synonym: "organ system process" EXACT [] is_a: GO:0032501 ! multicellular organismal process property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0003009 name: skeletal muscle contraction namespace: biological_process def: "A process in which force is generated within skeletal muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. In the skeletal muscle, the muscle contraction takes advantage of an ordered sarcomeric structure and in most cases it is under voluntary control." [GOC:mtg_cardio, GOC:mtg_muscle] is_a: GO:0006941 ! striated muscle contraction intersection_of: GO:0006936 ! muscle contraction intersection_of: BFO:0000066 UBERON:0001134 ! occurs in skeletal muscle tissue relationship: BFO:0000050 GO:0050881 ! part of musculoskeletal movement relationship: BFO:0000066 UBERON:0001134 ! occurs in skeletal muscle tissue [Term] id: GO:0003012 name: muscle system process namespace: biological_process def: "An organ system process carried out at the level of a muscle. Muscle tissue is composed of contractile cells or fibers." [GOC:mtg_cardio] subset: goslim_drosophila subset: goslim_generic synonym: "muscle physiological process" RELATED [] is_a: GO:0003008 ! system process property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0003013 name: circulatory system process namespace: biological_process def: "An organ system process carried out by any of the organs or tissues of the circulatory system. The circulatory system is an organ system that moves extracellular fluids to and from tissue within a multicellular organism." [GOC:mtg_cardio] subset: goslim_chembl subset: goslim_generic xref: Wikipedia:Circulatory_system is_a: GO:0003008 ! system process property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0003014 name: renal system process namespace: biological_process def: "An organ system process carried out by any of the organs or tissues of the renal system. The renal system maintains fluid balance, and contributes to electrolyte balance, acid/base balance, and disposal of nitrogenous waste products. In humans, the renal system comprises a pair of kidneys, a pair of ureters, urinary bladder, urethra, sphincter muscle and associated blood vessels; in other species, the renal system may comprise related structures (e.g., nephrocytes and malpighian tubules in Drosophila)." [GOC:cjm, GOC:mtg_cardio, GOC:mtg_kidney_jan10] subset: goslim_generic synonym: "excretory system process" EXACT [] synonym: "kidney system process" RELATED [] is_a: GO:0003008 ! system process property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0003015 name: heart process namespace: biological_process def: "A circulatory system process carried out by the heart. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood." [GOC:mtg_cardio] synonym: "cardiac process" RELATED [] is_a: GO:0003013 ! circulatory system process property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0003016 name: respiratory system process namespace: biological_process def: "A process carried out by the organs or tissues of the respiratory system. The respiratory system is an organ system responsible for respiratory gaseous exchange." [GOC:dph, GOC:mtg_cardio, GOC:tb] subset: goslim_generic synonym: "respiratory gaseous exchange" EXACT [] is_a: GO:0003008 ! system process relationship: BFO:0000050 GO:0007585 ! part of respiratory gaseous exchange by respiratory system property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0003018 name: vascular process in circulatory system namespace: biological_process def: "A circulatory process that occurs at the level of the vasculature." [GOC:mtg_cardio] synonym: "vasculature process" EXACT [] is_a: GO:0003013 ! circulatory system process property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0003032 name: detection of oxygen namespace: biological_process def: "The series of events in which an oxygen stimulus is received by a cell and converted into a molecular signal." [GOC:mtg_cardio] is_a: GO:0009593 ! detection of chemical stimulus is_a: GO:0070482 ! response to oxygen levels [Term] id: GO:0003044 name: regulation of systemic arterial blood pressure mediated by a chemical signal namespace: biological_process def: "The regulation of blood pressure mediated by biochemical signaling: hormonal, autocrine or paracrine." [GOC:mtg_cardio] synonym: "blood pressure regulation mediated by a chemical signal" EXACT [] is_a: GO:0003073 ! regulation of systemic arterial blood pressure property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0003071 name: renal system process involved in regulation of systemic arterial blood pressure namespace: biological_process def: "Renal process that modulates the force with which blood travels through the circulatory system. The process is controlled by a balance of processes that increase pressure and decrease pressure." [GOC:dph, GOC:mtg_cardio, GOC:tb] synonym: "renal control of blood pressure" EXACT [] synonym: "renal regulation of systemic arterial blood pressure" EXACT [GOC:dph, GOC:tb] is_a: GO:0003014 ! renal system process intersection_of: GO:0003014 ! renal system process intersection_of: BFO:0000050 GO:0003073 ! part of regulation of systemic arterial blood pressure relationship: BFO:0000050 GO:0003073 ! part of regulation of systemic arterial blood pressure property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0003073 name: regulation of systemic arterial blood pressure namespace: biological_process def: "The process that modulates the force with which blood travels through the systemic arterial circulatory system. The process is controlled by a balance of processes that increase pressure and decrease pressure." [GOC:mtg_cardio] is_a: GO:0008217 ! regulation of blood pressure property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0003081 name: regulation of systemic arterial blood pressure by renin-angiotensin namespace: biological_process def: "The process in which renin-angiotensin modulates the force with which blood passes through the circulatory system." [GOC:mtg_cardio] synonym: "blood pressure regulation by renin-angiotensin" EXACT [] is_a: GO:0001990 ! regulation of systemic arterial blood pressure by hormone property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0003091 name: renal water homeostasis namespace: biological_process def: "Renal process involved in the maintenance of an internal steady state of water in the body." [GOC:mtg_cardio] synonym: "water homeostasis by the renal system" EXACT [] xref: Reactome:R-HSA-432040 "Vasopressin regulates renal water homeostasis via Aquaporins" is_a: GO:0003014 ! renal system process is_a: GO:0050891 ! multicellular organismal-level water homeostasis property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0003093 name: regulation of glomerular filtration namespace: biological_process def: "Any process that modulates the frequency, rate or extent of glomerular filtration. Glomerular filtration is the process in which blood is filtered by the glomerulus into the renal tubule." [GOC:mtg_cardio] is_a: GO:0001977 ! renal system process involved in regulation of blood volume is_a: GO:0098801 ! regulation of renal system process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0003094 ! regulates glomerular filtration relationship: RO:0002211 GO:0003094 ! regulates glomerular filtration property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0003094 name: glomerular filtration namespace: biological_process def: "The process in which plasma is filtered through the glomerular membrane which consists of capillary endothelial cells, the basement membrane, and epithelial cells. The glomerular filtrate is the same as plasma except it has no significant amount of protein." [GOC:mtg_cardio, GOC:sart, ISBN:0721643949] is_a: BFO:0000003 is_a: GO:0097205 ! renal filtration intersection_of: GO:0097205 ! renal filtration intersection_of: BFO:0000066 UBERON:0000074 ! occurs in renal glomerulus relationship: BFO:0000066 UBERON:0000074 ! occurs in renal glomerulus property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0003096 name: renal sodium ion transport namespace: biological_process def: "The directed movement of sodium ions (Na+) by the renal system." [GOC:mtg_cardio] is_a: GO:0003014 ! renal system process is_a: GO:0006814 ! sodium ion transport intersection_of: GO:0006814 ! sodium ion transport intersection_of: BFO:0000066 UBERON:0001008 ! occurs in renal system relationship: BFO:0000066 UBERON:0001008 ! occurs in renal system property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0003097 name: renal water transport namespace: biological_process def: "The directed movement of water (H2O) by the renal system." [GOC:mtg_cardio] is_a: GO:0003014 ! renal system process is_a: GO:0006833 ! water transport intersection_of: GO:0006833 ! water transport intersection_of: BFO:0000066 UBERON:0001008 ! occurs in renal system relationship: BFO:0000050 GO:0003091 ! part of renal water homeostasis relationship: BFO:0000066 UBERON:0001008 ! occurs in renal system property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0003104 name: positive regulation of glomerular filtration namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of glomerular filtration. Glomerular filtration is the process whereby blood is filtered by the glomerulus into the renal tubule." [GOC:mtg_cardio] is_a: GO:0003093 ! regulation of glomerular filtration is_a: GO:0051240 ! positive regulation of multicellular organismal process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0003094 ! positively regulates glomerular filtration relationship: RO:0002213 GO:0003094 ! positively regulates glomerular filtration property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0003105 name: negative regulation of glomerular filtration namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of glomerular filtration. Glomerular filtration is the process whereby blood is filtered by the glomerulus into the renal tubule." [GOC:mtg_cardio] is_a: GO:0003093 ! regulation of glomerular filtration is_a: GO:0051241 ! negative regulation of multicellular organismal process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0003094 ! negatively regulates glomerular filtration relationship: RO:0002212 GO:0003094 ! negatively regulates glomerular filtration property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0003131 name: mesodermal-endodermal cell signaling namespace: biological_process def: "Any process that mediates the transfer of information from mesodermal cells to endodermal cells." [GOC:mtg_heart] synonym: "mesodermal-endodermal cell signalling" EXACT [GOC:mah] is_a: GO:0007267 ! cell-cell signaling intersection_of: GO:0007267 ! cell-cell signaling intersection_of: RO:0002231 CL:0000222 ! has start location mesodermal cell intersection_of: RO:0002232 CL:0000223 ! has end location endodermal cell relationship: RO:0002231 CL:0000222 ! has start location mesodermal cell relationship: RO:0002232 CL:0000223 ! has end location endodermal cell creation_date: 2009-09-22T03:07:34Z [Term] id: GO:0003133 name: endodermal-mesodermal cell signaling namespace: biological_process def: "Any process that mediates the transfer of information from endodermal cells to mesodermal cells." [GOC:mtg_heart] synonym: "endodermal-mesodermal cell signalling" EXACT [GOC:mah] is_a: GO:0007267 ! cell-cell signaling intersection_of: GO:0007267 ! cell-cell signaling intersection_of: RO:0002231 CL:0000223 ! has start location endodermal cell intersection_of: RO:0002232 CL:0000222 ! has end location mesodermal cell relationship: RO:0002231 CL:0000223 ! has start location endodermal cell relationship: RO:0002232 CL:0000222 ! has end location mesodermal cell creation_date: 2009-09-22T03:10:29Z [Term] id: GO:0003142 name: cardiogenic plate morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the cardiogenic plate are generated and organized. The cardiogenic plate is the first recognizable structure derived from the heart field." [GOC:mtg_heart] synonym: "cardiac crescent morphogenesis" EXACT [GOC:mtg_heart] is_a: BFO:0000003 is_a: GO:0009653 ! anatomical structure morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0004139 ! results in morphogenesis of cardiogenic plate relationship: BFO:0000050 GO:0003007 ! part of heart morphogenesis relationship: RO:0002298 UBERON:0004139 ! results in morphogenesis of cardiogenic plate creation_date: 2009-09-22T04:12:18Z [Term] id: GO:0003143 name: embryonic heart tube morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the embryonic heart tube are generated and organized. The embryonic heart tube is an epithelial tube that will give rise to the mature heart." [GOC:mtg_heart] is_a: GO:0048598 ! embryonic morphogenesis is_a: GO:0060562 ! epithelial tube morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0004141 ! results in morphogenesis of heart tube relationship: BFO:0000050 GO:0003007 ! part of heart morphogenesis relationship: BFO:0000050 GO:0035050 ! part of embryonic heart tube development relationship: BFO:0000050 GO:0048562 ! part of embryonic organ morphogenesis relationship: RO:0002298 UBERON:0004141 ! results in morphogenesis of heart tube creation_date: 2009-09-22T04:21:17Z [Term] id: GO:0003144 name: embryonic heart tube formation namespace: biological_process def: "The process that gives rise to the embryonic heart tube. This process pertains to the initial formation of a structure from unspecified parts. The embryonic heart tube is an epithelial tube that will give rise to the mature heart." [GOC:mtg_heart] is_a: GO:0001838 ! embryonic epithelial tube formation intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0004141 ! results in formation of anatomical entity heart tube relationship: BFO:0000050 GO:0003143 ! part of embryonic heart tube morphogenesis relationship: RO:0002297 UBERON:0004141 ! results in formation of anatomical entity heart tube creation_date: 2009-09-22T04:22:34Z [Term] id: GO:0003145 name: embryonic heart tube formation via epithelial folding namespace: biological_process def: "The process that gives rise to the embryonic heart tube by the cells of the heart field along a linear axis." [GOC:mtg_heart] is_a: GO:0003144 ! embryonic heart tube formation creation_date: 2009-09-22T04:26:03Z [Term] id: GO:0003147 name: neural crest cell migration involved in heart formation namespace: biological_process def: "The characteristic movement of a cell from the dorsal ridge of the neural tube towards the heart and that contributes to heart formation." [GOC:mtg_heart] is_a: GO:0001755 ! neural crest cell migration is_a: GO:0060974 ! cell migration involved in heart formation intersection_of: GO:0001755 ! neural crest cell migration intersection_of: BFO:0000050 GO:0060914 ! part of heart formation relationship: BFO:0000050 GO:0061308 ! part of cardiac neural crest cell development involved in heart development creation_date: 2009-09-22T04:29:55Z [Term] id: GO:0003148 name: outflow tract septum morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the outflow tract septum are generated and organized. The outflow tract septum is a partition in the outflow tract." [GOC:mtg_heart] is_a: GO:0060411 ! cardiac septum morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0004142 ! results in morphogenesis of outflow tract septum relationship: BFO:0000050 GO:0003151 ! part of outflow tract morphogenesis relationship: RO:0002298 UBERON:0004142 ! results in morphogenesis of outflow tract septum creation_date: 2009-09-22T07:51:01Z [Term] id: GO:0003149 name: membranous septum morphogenesis namespace: biological_process def: "The process in which the membranous septum is generated and organized. The membranous septum is the upper part of ventricular septum." [GOC:mtg_heart] is_a: BFO:0000003 is_a: GO:0009653 ! anatomical structure morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0004666 ! results in morphogenesis of interventricular septum membranous part relationship: BFO:0000050 GO:0060412 ! part of ventricular septum morphogenesis relationship: RO:0002298 UBERON:0004666 ! results in morphogenesis of interventricular septum membranous part creation_date: 2009-09-22T07:51:41Z [Term] id: GO:0003150 name: muscular septum morphogenesis namespace: biological_process def: "The process in which the muscular septum is generated and organized. The muscular septum is the lower part of the ventricular septum." [GOC:mtg_heart] is_a: GO:0060415 ! muscle tissue morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0004667 ! results in morphogenesis of interventricular septum muscular part relationship: BFO:0000050 GO:0060412 ! part of ventricular septum morphogenesis relationship: RO:0002298 UBERON:0004667 ! results in morphogenesis of interventricular septum muscular part creation_date: 2009-09-22T07:53:28Z [Term] id: GO:0003151 name: outflow tract morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the outflow tract are generated and organized. The outflow tract is the portion of the heart through which blood flows into the arteries." [GOC:mtg_heart, UBERON:0004145] is_a: BFO:0000003 is_a: GO:0009653 ! anatomical structure morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0004145 ! results in morphogenesis of outflow tract relationship: BFO:0000050 GO:0003007 ! part of heart morphogenesis relationship: RO:0002298 UBERON:0004145 ! results in morphogenesis of outflow tract creation_date: 2009-09-22T07:59:24Z [Term] id: GO:0003152 name: morphogenesis of an epithelial fold involved in embryonic heart tube formation namespace: biological_process def: "The morphogenetic process in which an epithelial sheet bends along a linear axis, contributing to embryonic heart tube formation." [GOC:mtg_heart] is_a: GO:0048598 ! embryonic morphogenesis is_a: GO:0060571 ! morphogenesis of an epithelial fold intersection_of: GO:0060571 ! morphogenesis of an epithelial fold intersection_of: BFO:0000050 GO:0003144 ! part of embryonic heart tube formation relationship: BFO:0000050 GO:0003145 ! part of embryonic heart tube formation via epithelial folding creation_date: 2009-09-23T10:10:24Z [Term] id: GO:0003156 name: regulation of animal organ formation namespace: biological_process def: "Any process that modulates the rate, frequency or extent of animal organ formation. Organ formation is the process pertaining to the initial formation of an organ from unspecified parts. The process begins with the specific processes that contribute to the appearance of the discrete structure, such as inductive events, and ends when the structural rudiment of the organ is recognizable, such as a condensation of mesenchymal cells into the organ rudiment." [GOC:dph, GOC:mtg_heart, GOC:tb] is_a: GO:2000027 ! regulation of animal organ morphogenesis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0048645 ! regulates animal organ formation relationship: RO:0002211 GO:0048645 ! regulates animal organ formation creation_date: 2009-09-30T11:21:09Z [Term] id: GO:0003157 name: endocardium development namespace: biological_process def: "The process whose specific outcome is the progression of the endocardium over time, from its formation to the mature structure. The endocardium is an anatomical structure comprised of an endothelium and an extracellular matrix that forms the innermost layer of tissue of the heart, and lines the heart chambers." [GOC:mtg_heart] is_a: GO:0048856 ! anatomical structure development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0002165 ! results in development of endocardium relationship: BFO:0000050 GO:0007507 ! part of heart development relationship: RO:0002296 UBERON:0002165 ! results in development of endocardium creation_date: 2009-10-01T12:42:27Z [Term] id: GO:0003158 name: endothelium development namespace: biological_process def: "The process whose specific outcome is the progression of an endothelium over time, from its formation to the mature structure. Endothelium refers to the layer of cells lining blood vessels, lymphatics, the heart, and serous cavities, and is derived from bone marrow or mesoderm. Corneal endothelium is a special case, derived from neural crest cells." [GOC:mtg_heart] is_a: GO:0060429 ! epithelium development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0001986 ! results in development of endothelium relationship: RO:0002296 UBERON:0001986 ! results in development of endothelium creation_date: 2009-10-01T12:50:57Z [Term] id: GO:0003159 name: morphogenesis of an endothelium namespace: biological_process def: "The process in which the anatomical structure of an endothelium is generated and organized. Endothelium refers to the layer of cells lining blood vessels, lymphatics, the heart, and serous cavities, and is derived from bone marrow or mesoderm. Corneal endothelium is a special case, derived from neural crest cells." [GOC:mtg_heart] is_a: GO:0002009 ! morphogenesis of an epithelium intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0001986 ! results in morphogenesis of endothelium relationship: BFO:0000050 GO:0003158 ! part of endothelium development relationship: RO:0002298 UBERON:0001986 ! results in morphogenesis of endothelium creation_date: 2009-10-01T01:34:06Z [Term] id: GO:0003160 name: endocardium morphogenesis namespace: biological_process def: "The process in which the anatomical structure of the endocardium is generated and organized. The endocardium is an anatomical structure comprised of an endothelium and an extracellular matrix that forms the innermost layer of tissue of the heart, and lines the heart chambers." [GOC:mtg_heart] is_a: BFO:0000003 is_a: GO:0009653 ! anatomical structure morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0002165 ! results in morphogenesis of endocardium relationship: BFO:0000050 GO:0003157 ! part of endocardium development relationship: RO:0002298 UBERON:0002165 ! results in morphogenesis of endocardium creation_date: 2009-10-01T01:37:26Z [Term] id: GO:0003161 name: cardiac conduction system development namespace: biological_process def: "The process whose specific outcome is the progression of the cardiac conduction system over time, from its formation to the mature structure. The cardiac conduction system consists of specialized cardiomyocytes that regulate the frequency of heart beat." [GOC:mtg_heart] synonym: "cardiac impulse conducting system development" EXACT [GOC:mtg_heart] synonym: "heart conduction system development" EXACT [GOC:mtg_heart] is_a: GO:0048738 ! cardiac muscle tissue development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0002350 ! results in development of conducting system of heart relationship: RO:0002296 UBERON:0002350 ! results in development of conducting system of heart creation_date: 2009-10-01T01:57:16Z [Term] id: GO:0003162 name: atrioventricular node development namespace: biological_process def: "The process whose specific outcome is the progression of the atrioventricular (AV) node over time, from its formation to the mature structure. The AV node is part of the cardiac conduction system that controls the timing of ventricle contraction by receiving electrical signals from the sinoatrial (SA) node and relaying them to the His-Purkinje system." [GOC:mtg_heart] synonym: "AV node development" EXACT [GOC:mtg_heart] is_a: GO:0048738 ! cardiac muscle tissue development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0002352 ! results in development of atrioventricular node relationship: BFO:0000050 GO:0003161 ! part of cardiac conduction system development relationship: RO:0002296 UBERON:0002352 ! results in development of atrioventricular node creation_date: 2009-10-01T02:05:13Z [Term] id: GO:0003163 name: sinoatrial node development namespace: biological_process def: "The process whose specific outcome is the progression of the sinoatrial (SA) node over time, from its formation to the mature structure. The SA node is part of the cardiac conduction system that controls the timing of heart muscle contraction. It relays electrical signals to the AV node." [GOC:mtg_heart] synonym: "SA node development" EXACT [GOC:mtg_heart] synonym: "SAN development" EXACT [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] synonym: "sinus node development" NARROW [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] is_a: GO:0003228 ! atrial cardiac muscle tissue development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0002351 ! results in development of sinoatrial node relationship: BFO:0000050 GO:0003161 ! part of cardiac conduction system development relationship: RO:0002296 UBERON:0002351 ! results in development of sinoatrial node creation_date: 2009-10-01T02:06:09Z [Term] id: GO:0003164 name: His-Purkinje system development namespace: biological_process def: "The process whose specific outcome is the progression of the His-Purkinje system over time, from its formation to the mature structure. The His-Purkinje system receives signals from the AV node and is composed of the fibers that regulate cardiac muscle contraction in the ventricles." [GOC:mtg_heart] is_a: GO:0003229 ! ventricular cardiac muscle tissue development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0004146 ! results in development of His-Purkinje system relationship: BFO:0000050 GO:0003161 ! part of cardiac conduction system development relationship: RO:0002296 UBERON:0004146 ! results in development of His-Purkinje system creation_date: 2009-10-01T02:07:12Z [Term] id: GO:0003165 name: Purkinje myocyte development namespace: biological_process def: "The process whose specific outcome is the progression of a Purkinje myocyte over time, from its formation to the mature structure. The Purkinje myocyte (also known as cardiac Purkinje fiber) is part of the cardiac conduction system that receives signals from the bundle of His and innervates the ventricular cardiac muscle." [GOC:mtg_cardiac_conduct_nov11, GOC:mtg_heart] synonym: "cardiac Purkinje fiber development" EXACT [] is_a: GO:0003229 ! ventricular cardiac muscle tissue development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0002354 ! results in development of cardiac Purkinje fiber relationship: BFO:0000050 GO:0003164 ! part of His-Purkinje system development relationship: RO:0002296 UBERON:0002354 ! results in development of cardiac Purkinje fiber creation_date: 2009-10-01T02:07:50Z [Term] id: GO:0003166 name: bundle of His development namespace: biological_process def: "The process whose specific outcome is the progression of the bundle of His over time, from its formation to the mature structure. The bundle of His is part of the His-Purkinje system that transmits signals from the AV node to the cardiac Purkinje fibers." [GOC:mtg_heart] synonym: "atrioventricular bundle development" EXACT [GOC:mtg_heart] is_a: GO:0003229 ! ventricular cardiac muscle tissue development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0002353 ! results in development of bundle of His relationship: BFO:0000050 GO:0003164 ! part of His-Purkinje system development relationship: RO:0002296 UBERON:0002353 ! results in development of bundle of His creation_date: 2009-10-01T02:08:43Z [Term] id: GO:0003167 name: atrioventricular bundle cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of a cell of the atrioventricular bundle. These cells are specialized cardiomyocytes that transmit signals from the AV node to the cardiac Purkinje fibers." [GOC:mtg_heart] synonym: "AV bundle cell differentiation" EXACT [GOC:mtg_heart] is_a: GO:0060932 ! His-Purkinje system cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0010005 ! results in acquisition of features of atrioventricular bundle cell relationship: BFO:0000050 GO:0003166 ! part of bundle of His development relationship: RO:0002315 CL:0010005 ! results in acquisition of features of atrioventricular bundle cell creation_date: 2009-10-01T02:48:23Z [Term] id: GO:0003168 name: Purkinje myocyte differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of a Purkinje myocyte (also known as cardiac Purkinje fiber cell). These cells are specialized cardiomyocytes that receive signals from the bundle of His and innervate the ventricular cardiac muscle." [GOC:mtg_cardiac_conduct_nov11, GOC:mtg_heart] synonym: "cardiac Purkinje fiber cell differentiation" EXACT [] is_a: GO:0060932 ! His-Purkinje system cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0002068 ! results in acquisition of features of Purkinje myocyte relationship: BFO:0000050 GO:0003165 ! part of Purkinje myocyte development relationship: RO:0002315 CL:0002068 ! results in acquisition of features of Purkinje myocyte creation_date: 2009-10-01T02:49:54Z [Term] id: GO:0003169 name: coronary vein morphogenesis namespace: biological_process def: "The process in which the anatomical structures of veins of the heart are generated and organized." [GOC:mtg_heart] is_a: GO:0048845 ! venous blood vessel morphogenesis is_a: GO:0060977 ! coronary vasculature morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0004148 ! results in morphogenesis of cardiac vein relationship: RO:0002298 UBERON:0004148 ! results in morphogenesis of cardiac vein creation_date: 2009-10-08T10:45:41Z [Term] id: GO:0003170 name: heart valve development namespace: biological_process def: "The progression of a heart valve over time, from its formation to the mature structure. A heart valve is a structure that restricts the flow of blood to different regions of the heart and forms from an endocardial cushion." [GOC:mtg_heart] synonym: "cardiac valve development" EXACT [GOC:mtg_heart] is_a: GO:0048856 ! anatomical structure development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0000946 ! results in development of cardiac valve relationship: BFO:0000050 GO:0007507 ! part of heart development relationship: RO:0002296 UBERON:0000946 ! results in development of cardiac valve creation_date: 2009-10-08T10:50:09Z [Term] id: GO:0003179 name: heart valve morphogenesis namespace: biological_process def: "The process in which the structure of a heart valve is generated and organized." [GOC:mtg_heart] synonym: "heart valve remodeling" NARROW [GOC:vk, GOC:yaf] synonym: "heart valve remodelling" NARROW [GOC:vk, GOC:yaf] is_a: BFO:0000003 is_a: GO:0009653 ! anatomical structure morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0000946 ! results in morphogenesis of cardiac valve relationship: BFO:0000050 GO:0003170 ! part of heart valve development relationship: RO:0002298 UBERON:0000946 ! results in morphogenesis of cardiac valve creation_date: 2009-10-08T11:23:48Z [Term] id: GO:0003188 name: heart valve formation namespace: biological_process def: "The developmental process pertaining to the initial formation of a heart valve from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable." [GOC:mtg_heart] is_a: BFO:0000003 is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0000946 ! results in formation of anatomical entity cardiac valve relationship: BFO:0000050 GO:0003179 ! part of heart valve morphogenesis relationship: RO:0002297 UBERON:0000946 ! results in formation of anatomical entity cardiac valve creation_date: 2009-10-08T12:20:15Z [Term] id: GO:0003197 name: endocardial cushion development namespace: biological_process def: "The progression of a cardiac cushion over time, from its initial formation to the mature structure. The endocardial cushion is a specialized region of mesenchymal cells that will give rise to the heart septa and valves." [GOC:mtg_heart] is_a: GO:0060485 ! mesenchyme development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0002062 ! results in development of endocardial cushion relationship: BFO:0000050 GO:0007507 ! part of heart development relationship: RO:0002296 UBERON:0002062 ! results in development of endocardial cushion creation_date: 2009-10-08T01:17:43Z [Term] id: GO:0003203 name: endocardial cushion morphogenesis namespace: biological_process def: "The process in which the anatomical structure of the endocardial cushion is generated and organized. The endocardial cushion is a specialized region of mesenchymal cells that will give rise to the heart septa and valves." [GOC:mtg_heart] is_a: GO:0072132 ! mesenchyme morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0002062 ! results in morphogenesis of endocardial cushion relationship: BFO:0000050 GO:0003007 ! part of heart morphogenesis relationship: BFO:0000050 GO:0003197 ! part of endocardial cushion development relationship: RO:0002298 UBERON:0002062 ! results in morphogenesis of endocardial cushion creation_date: 2009-10-08T01:43:22Z [Term] id: GO:0003204 name: cardiac skeleton development namespace: biological_process def: "The progression of the cardiac skeleton over time, from its formation to the mature structure. The cardiac skeleton is a specialized extracellular matrix that separates the atria from the ventricles and provides physical support for the heart." [GOC:mtg_heart] synonym: "heart fibrous skeleton development" EXACT [GOC:mtg_heart] is_a: GO:0061448 ! connective tissue development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0004292 ! results in development of cardiac skeleton relationship: BFO:0000050 GO:0007507 ! part of heart development relationship: RO:0002296 UBERON:0004292 ! results in development of cardiac skeleton creation_date: 2009-10-13T09:05:04Z [Term] id: GO:0003205 name: cardiac chamber development namespace: biological_process def: "The progression of a cardiac chamber over time, from its formation to the mature structure. A cardiac chamber is an enclosed cavity within the heart." [GOC:mtg_heart] is_a: GO:0048856 ! anatomical structure development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0004151 ! results in development of cardiac chamber relationship: BFO:0000050 GO:0007507 ! part of heart development relationship: RO:0002296 UBERON:0004151 ! results in development of cardiac chamber creation_date: 2009-10-13T09:11:18Z [Term] id: GO:0003206 name: cardiac chamber morphogenesis namespace: biological_process def: "The process in which a cardiac chamber is generated and organized. A cardiac chamber is an enclosed cavity within the heart." [GOC:mtg_heart] synonym: "heart chamber morphogenesis" EXACT [GOC:mtg_heart] is_a: BFO:0000003 is_a: GO:0009653 ! anatomical structure morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0004151 ! results in morphogenesis of cardiac chamber relationship: BFO:0000050 GO:0003007 ! part of heart morphogenesis relationship: BFO:0000050 GO:0003205 ! part of cardiac chamber development relationship: RO:0002298 UBERON:0004151 ! results in morphogenesis of cardiac chamber creation_date: 2009-10-13T09:14:51Z [Term] id: GO:0003207 name: cardiac chamber formation namespace: biological_process def: "The developmental process pertaining to the initial formation of a cardiac chamber from unspecified parts. A cardiac chamber is an enclosed cavity within the heart." [GOC:mtg_heart] synonym: "heart chamber formation" EXACT [GOC:mtg_heart] is_a: BFO:0000003 is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0004151 ! results in formation of anatomical entity cardiac chamber relationship: BFO:0000050 GO:0003206 ! part of cardiac chamber morphogenesis relationship: RO:0002297 UBERON:0004151 ! results in formation of anatomical entity cardiac chamber creation_date: 2009-10-13T09:29:13Z [Term] id: GO:0003208 name: cardiac ventricle morphogenesis namespace: biological_process def: "The process in which the cardiac ventricle is generated and organized. A cardiac ventricle receives blood from a cardiac atrium and pumps it out of the heart." [GOC:mtg_heart] is_a: GO:0003206 ! cardiac chamber morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0002082 ! results in morphogenesis of cardiac ventricle relationship: BFO:0000050 GO:0003231 ! part of cardiac ventricle development relationship: RO:0002298 UBERON:0002082 ! results in morphogenesis of cardiac ventricle creation_date: 2009-10-13T09:38:44Z [Term] id: GO:0003209 name: cardiac atrium morphogenesis namespace: biological_process def: "The process in which the cardiac atrium is generated and organized. A cardiac atrium receives blood from a vein and pumps it to a cardiac ventricle." [GOC:mtg_heart] is_a: GO:0003206 ! cardiac chamber morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0002081 ! results in morphogenesis of cardiac atrium relationship: BFO:0000050 GO:0003230 ! part of cardiac atrium development relationship: RO:0002298 UBERON:0002081 ! results in morphogenesis of cardiac atrium creation_date: 2009-10-13T09:39:44Z [Term] id: GO:0003210 name: cardiac atrium formation namespace: biological_process def: "The developmental process pertaining to the initial formation of a cardiac atrium from unspecified parts. A cardiac atrium receives blood from a vein and pumps it to a cardiac ventricle." [GOC:mtg_heart] is_a: GO:0003207 ! cardiac chamber formation intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0002081 ! results in formation of anatomical entity cardiac atrium relationship: BFO:0000050 GO:0003209 ! part of cardiac atrium morphogenesis relationship: RO:0002297 UBERON:0002081 ! results in formation of anatomical entity cardiac atrium creation_date: 2009-10-13T09:44:25Z [Term] id: GO:0003211 name: cardiac ventricle formation namespace: biological_process def: "The developmental process pertaining to the initial formation of a cardiac ventricle from unspecified parts. A cardiac ventricle receives blood from a cardiac atrium and pumps it out of the heart." [GOC:mtg_heart] is_a: GO:0003207 ! cardiac chamber formation intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0002082 ! results in formation of anatomical entity cardiac ventricle relationship: BFO:0000050 GO:0003208 ! part of cardiac ventricle morphogenesis relationship: RO:0002297 UBERON:0002082 ! results in formation of anatomical entity cardiac ventricle creation_date: 2009-10-13T09:46:27Z [Term] id: GO:0003212 name: cardiac left atrium morphogenesis namespace: biological_process def: "The process in which the left cardiac atrium is generated and organized." [GOC:mtg_heart] is_a: GO:0003209 ! cardiac atrium morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0002079 ! results in morphogenesis of left cardiac atrium relationship: RO:0002298 UBERON:0002079 ! results in morphogenesis of left cardiac atrium creation_date: 2009-10-13T09:48:16Z [Term] id: GO:0003213 name: cardiac right atrium morphogenesis namespace: biological_process def: "The process in which the right cardiac atrium is generated and organized." [GOC:mtg_heart] is_a: GO:0003209 ! cardiac atrium morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0002078 ! results in morphogenesis of right cardiac atrium relationship: RO:0002298 UBERON:0002078 ! results in morphogenesis of right cardiac atrium creation_date: 2009-10-13T09:49:03Z [Term] id: GO:0003214 name: cardiac left ventricle morphogenesis namespace: biological_process def: "The process in which the left cardiac ventricle is generated and organized." [GOC:mtg_heart] is_a: GO:0003208 ! cardiac ventricle morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0002084 ! results in morphogenesis of heart left ventricle relationship: RO:0002298 UBERON:0002084 ! results in morphogenesis of heart left ventricle creation_date: 2009-10-13T09:50:08Z [Term] id: GO:0003215 name: cardiac right ventricle morphogenesis namespace: biological_process def: "The process in which the right cardiac ventricle is generated and organized." [GOC:mtg_heart] is_a: GO:0003208 ! cardiac ventricle morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0002080 ! results in morphogenesis of heart right ventricle relationship: RO:0002298 UBERON:0002080 ! results in morphogenesis of heart right ventricle creation_date: 2009-10-13T09:50:57Z [Term] id: GO:0003216 name: cardiac left atrium formation namespace: biological_process def: "The developmental process pertaining to the initial formation of a left cardiac atrium from unspecified parts." [GOC:mtg_heart] is_a: GO:0003210 ! cardiac atrium formation intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0002079 ! results in formation of anatomical entity left cardiac atrium relationship: BFO:0000050 GO:0003212 ! part of cardiac left atrium morphogenesis relationship: RO:0002297 UBERON:0002079 ! results in formation of anatomical entity left cardiac atrium creation_date: 2009-10-13T09:52:31Z [Term] id: GO:0003217 name: cardiac right atrium formation namespace: biological_process def: "The developmental process pertaining to the initial formation of a cardiac right atrium from unspecified parts." [GOC:mtg_heart] is_a: GO:0003210 ! cardiac atrium formation intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0002078 ! results in formation of anatomical entity right cardiac atrium relationship: BFO:0000050 GO:0003213 ! part of cardiac right atrium morphogenesis relationship: RO:0002297 UBERON:0002078 ! results in formation of anatomical entity right cardiac atrium creation_date: 2009-10-13T09:53:12Z [Term] id: GO:0003218 name: cardiac left ventricle formation namespace: biological_process def: "The developmental process pertaining to the initial formation of a left cardiac ventricle from unspecified parts." [GOC:mtg_heart] is_a: GO:0003211 ! cardiac ventricle formation intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0002084 ! results in formation of anatomical entity heart left ventricle relationship: BFO:0000050 GO:0003214 ! part of cardiac left ventricle morphogenesis relationship: RO:0002297 UBERON:0002084 ! results in formation of anatomical entity heart left ventricle creation_date: 2009-10-13T09:54:33Z [Term] id: GO:0003219 name: cardiac right ventricle formation namespace: biological_process def: "The developmental process pertaining to the initial formation of a right cardiac ventricle from unspecified parts." [GOC:mtg_heart] is_a: GO:0003211 ! cardiac ventricle formation intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0002080 ! results in formation of anatomical entity heart right ventricle relationship: BFO:0000050 GO:0003215 ! part of cardiac right ventricle morphogenesis relationship: RO:0002297 UBERON:0002080 ! results in formation of anatomical entity heart right ventricle creation_date: 2009-10-13T09:55:38Z [Term] id: GO:0003220 name: left ventricular cardiac muscle tissue morphogenesis namespace: biological_process def: "The process in which the anatomical structures of left cardiac ventricle muscle are generated and organized." [GOC:mtg_heart] synonym: "left ventricular myocardium morphogenesis" EXACT [GOC:mtg_heart] is_a: GO:0055010 ! ventricular cardiac muscle tissue morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0003382 ! results in morphogenesis of cardiac muscle of left ventricle relationship: BFO:0000050 GO:0003214 ! part of cardiac left ventricle morphogenesis relationship: RO:0002298 UBERON:0003382 ! results in morphogenesis of cardiac muscle of left ventricle creation_date: 2009-10-13T10:18:05Z [Term] id: GO:0003221 name: right ventricular cardiac muscle tissue morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the right cardiac ventricle muscle are generated and organized." [GOC:mtg_heart] synonym: "right ventricle myocardium morphogenesis" EXACT [GOC:mtg_heart] is_a: GO:0055010 ! ventricular cardiac muscle tissue morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0003381 ! results in morphogenesis of cardiac muscle of right ventricle relationship: BFO:0000050 GO:0003215 ! part of cardiac right ventricle morphogenesis relationship: RO:0002298 UBERON:0003381 ! results in morphogenesis of cardiac muscle of right ventricle creation_date: 2009-10-13T10:26:33Z [Term] id: GO:0003222 name: ventricular trabecula myocardium morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the trabecular cardiac ventricle muscle are generated and organized." [GOC:mtg_heart] synonym: "trabecula carnea morphogenesis" RELATED [GOC:dph] is_a: GO:0055010 ! ventricular cardiac muscle tissue morphogenesis is_a: GO:0061384 ! heart trabecula morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0004126 ! results in morphogenesis of trabecular layer of ventricle relationship: RO:0002298 UBERON:0004126 ! results in morphogenesis of trabecular layer of ventricle creation_date: 2009-10-13T10:33:00Z [Term] id: GO:0003225 name: left ventricular trabecular myocardium morphogenesis namespace: biological_process def: "The process in which the anatomical structures of cardiac left ventricular trabecular myocardium are generated and organized." [GOC:mtg_heart] is_a: GO:0003220 ! left ventricular cardiac muscle tissue morphogenesis is_a: GO:0003222 ! ventricular trabecula myocardium morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0005064 ! results in morphogenesis of left ventricular trabecular myocardium relationship: RO:0002298 UBERON:0005064 ! results in morphogenesis of left ventricular trabecular myocardium creation_date: 2009-10-13T10:45:09Z [Term] id: GO:0003227 name: right ventricular trabecular myocardium morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the right ventricular myocardium are generated and organized." [GOC:mtg_heart] is_a: GO:0003221 ! right ventricular cardiac muscle tissue morphogenesis is_a: GO:0003222 ! ventricular trabecula myocardium morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0005066 ! results in morphogenesis of right ventricular trabecular myocardium relationship: RO:0002298 UBERON:0005066 ! results in morphogenesis of right ventricular trabecular myocardium creation_date: 2009-10-13T10:50:59Z [Term] id: GO:0003228 name: atrial cardiac muscle tissue development namespace: biological_process def: "The process whose specific outcome is the progression of cardiac muscle of the atrium over time, from its formation to the mature structure." [GOC:mtg_heart] synonym: "atrial myocardium development" EXACT [GOC:mtg_heart] is_a: GO:0048738 ! cardiac muscle tissue development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0004490 ! results in development of cardiac muscle tissue of atrium relationship: RO:0002296 UBERON:0004490 ! results in development of cardiac muscle tissue of atrium property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/22614" xsd:anyURI creation_date: 2009-10-13T10:53:18Z [Term] id: GO:0003229 name: ventricular cardiac muscle tissue development namespace: biological_process def: "The process whose specific outcome is the progression of ventricular cardiac muscle over time, from its formation to the mature structure." [GOC:mtg_heart] synonym: "ventricular myocardium development" EXACT [GOC:mtg_heart] is_a: GO:0048738 ! cardiac muscle tissue development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0018649 ! results in development of cardiac muscle tissue of ventricle relationship: RO:0002296 UBERON:0018649 ! results in development of cardiac muscle tissue of ventricle creation_date: 2009-10-13T10:56:01Z [Term] id: GO:0003230 name: cardiac atrium development namespace: biological_process def: "The process whose specific outcome is the progression of a cardiac atrium over time, from its formation to the mature structure. A cardiac atrium receives blood from a vein and pumps it to a cardiac ventricle." [GOC:mtg_heart] is_a: GO:0003205 ! cardiac chamber development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0002081 ! results in development of cardiac atrium relationship: RO:0002296 UBERON:0002081 ! results in development of cardiac atrium creation_date: 2009-10-13T11:02:07Z [Term] id: GO:0003231 name: cardiac ventricle development namespace: biological_process def: "The process whose specific outcome is the progression of a cardiac ventricle over time, from its formation to the mature structure. A cardiac ventricle receives blood from a cardiac atrium and pumps it out of the heart." [GOC:mtg_heart] is_a: GO:0003205 ! cardiac chamber development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0002082 ! results in development of cardiac ventricle relationship: RO:0002296 UBERON:0002082 ! results in development of cardiac ventricle creation_date: 2009-10-13T11:03:16Z [Term] id: GO:0003235 name: sinus venosus development namespace: biological_process def: "The progression of the sinus venosus over time, from its formation to the mature structure. The sinus venosus is a heart chamber attached to the atrium on the venous side of the embryonic heart." [GOC:mtg_heart] is_a: GO:0003205 ! cardiac chamber development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0002063 ! results in development of sinus venosus relationship: RO:0002296 UBERON:0002063 ! results in development of sinus venosus creation_date: 2009-10-13T11:12:34Z [Term] id: GO:0003236 name: sinus venosus morphogenesis namespace: biological_process def: "The process in which the sinus venosus is generated and organized. The sinus venosus is a heart chamber attached to the atrium on the venous side of the embryonic heart." [GOC:mtg_heart] is_a: GO:0003206 ! cardiac chamber morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0002063 ! results in morphogenesis of sinus venosus relationship: BFO:0000050 GO:0003235 ! part of sinus venosus development relationship: RO:0002298 UBERON:0002063 ! results in morphogenesis of sinus venosus creation_date: 2009-10-13T11:16:52Z [Term] id: GO:0003237 name: sinus venosus formation namespace: biological_process def: "The developmental process pertaining to the initial formation of the sinus venosus from unspecified parts. The sinus venosus is a heart chamber attached to the atrium on the venous side of the embryonic heart." [GOC:mtg_heart] is_a: GO:0003207 ! cardiac chamber formation intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0002063 ! results in formation of anatomical entity sinus venosus relationship: BFO:0000050 GO:0003236 ! part of sinus venosus morphogenesis relationship: RO:0002297 UBERON:0002063 ! results in formation of anatomical entity sinus venosus creation_date: 2009-10-13T11:18:34Z [Term] id: GO:0003241 name: growth involved in heart morphogenesis namespace: biological_process def: "Developmental growth that contributes to the shaping of the heart." [GOC:mtg_heart] is_a: GO:0060560 ! developmental growth involved in morphogenesis intersection_of: GO:0040007 ! growth intersection_of: BFO:0000050 GO:0003007 ! part of heart morphogenesis relationship: BFO:0000050 GO:0003007 ! part of heart morphogenesis relationship: BFO:0000050 GO:0060419 ! part of heart growth creation_date: 2009-10-13T11:28:46Z [Term] id: GO:0003245 name: cardiac muscle tissue growth involved in heart morphogenesis namespace: biological_process def: "The developmental growth of cardiac muscle tissue that contributes to the shaping of the heart." [GOC:mtg_heart] is_a: GO:0003241 ! growth involved in heart morphogenesis is_a: GO:0055017 ! cardiac muscle tissue growth intersection_of: GO:0055017 ! cardiac muscle tissue growth intersection_of: BFO:0000050 GO:0003007 ! part of heart morphogenesis relationship: BFO:0000050 GO:0055008 ! part of cardiac muscle tissue morphogenesis creation_date: 2009-10-13T11:44:21Z [Term] id: GO:0003248 name: heart capillary growth namespace: biological_process def: "The increase in heart capillaries that accompanies physiological hypertrophy of cardiac muscle." [GOC:mtg_heart] is_a: BFO:0000003 is_a: GO:0048589 ! developmental growth intersection_of: GO:0048589 ! developmental growth intersection_of: RO:0002343 UBERON:0006966 ! results in growth of coronary capillary relationship: BFO:0000050 GO:0060419 ! part of heart growth relationship: BFO:0000050 GO:0060976 ! part of coronary vasculature development relationship: RO:0002343 UBERON:0006966 ! results in growth of coronary capillary creation_date: 2009-10-13T11:53:12Z [Term] id: GO:0003249 name: cell proliferation involved in heart valve morphogenesis namespace: biological_process def: "The multiplication or reproduction of cells that contributes to the shaping of a heart valve." [GOC:mtg_heart] is_a: GO:0061323 ! cell proliferation involved in heart morphogenesis is_a: GO:2000793 ! cell proliferation involved in heart valve development intersection_of: GO:0008283 ! cell population proliferation intersection_of: BFO:0000050 GO:0003179 ! part of heart valve morphogenesis relationship: BFO:0000050 GO:0003179 ! part of heart valve morphogenesis creation_date: 2009-10-13T01:59:19Z [Term] id: GO:0003250 name: regulation of cell proliferation involved in heart valve morphogenesis namespace: biological_process def: "Any process that modulates the rate, frequency or extent of cell proliferation that contributes to the shaping of a heart valve." [GOC:mtg_heart] is_a: GO:2000136 ! regulation of cell proliferation involved in heart morphogenesis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0003249 ! regulates cell proliferation involved in heart valve morphogenesis relationship: RO:0002211 GO:0003249 ! regulates cell proliferation involved in heart valve morphogenesis creation_date: 2009-10-13T02:03:42Z [Term] id: GO:0003251 name: positive regulation of cell proliferation involved in heart valve morphogenesis namespace: biological_process def: "Any process that increases the rate, frequency or extent of cell proliferation that contributes to the shaping of a heart valve." [GOC:mtg_heart] is_a: GO:0003250 ! regulation of cell proliferation involved in heart valve morphogenesis is_a: GO:2000138 ! positive regulation of cell proliferation involved in heart morphogenesis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0003249 ! positively regulates cell proliferation involved in heart valve morphogenesis relationship: RO:0002213 GO:0003249 ! positively regulates cell proliferation involved in heart valve morphogenesis creation_date: 2009-10-13T02:07:20Z [Term] id: GO:0003252 name: negative regulation of cell proliferation involved in heart valve morphogenesis namespace: biological_process def: "Any process that decreases the rate, frequency or extent of cell proliferation that contributes to the shaping of a heart valve." [GOC:mtg_heart] is_a: GO:0003250 ! regulation of cell proliferation involved in heart valve morphogenesis is_a: GO:2000137 ! negative regulation of cell proliferation involved in heart morphogenesis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0003249 ! negatively regulates cell proliferation involved in heart valve morphogenesis relationship: RO:0002212 GO:0003249 ! negatively regulates cell proliferation involved in heart valve morphogenesis creation_date: 2009-10-13T02:10:39Z [Term] id: GO:0003253 name: cardiac neural crest cell migration involved in outflow tract morphogenesis namespace: biological_process def: "The orderly movement of a neural crest cell from one site to another that will contribute to the morphogenesis of the outflow tract." [GOC:mtg_heart] is_a: GO:0001755 ! neural crest cell migration is_a: GO:0060973 ! cell migration involved in heart development intersection_of: GO:0001755 ! neural crest cell migration intersection_of: BFO:0000050 GO:0003151 ! part of outflow tract morphogenesis relationship: BFO:0000050 GO:0061309 ! part of cardiac neural crest cell development involved in outflow tract morphogenesis creation_date: 2009-10-13T02:14:16Z [Term] id: GO:0003254 name: regulation of membrane depolarization namespace: biological_process def: "Any process that modulates the rate, frequency or extent of membrane depolarization. Membrane depolarization is the process in which membrane potential changes in the depolarizing direction from the resting potential, usually from negative to positive." [GOC:dph, GOC:tb] is_a: GO:0042391 ! regulation of membrane potential is_a: GO:0050794 ! regulation of cellular process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0051899 ! regulates membrane depolarization relationship: RO:0002211 GO:0051899 ! regulates membrane depolarization creation_date: 2009-10-14T10:54:09Z [Term] id: GO:0003260 name: cardioblast migration namespace: biological_process def: "The orderly movement of a cardiac progenitor cell to form the heart field. Cardiac progenitor cells are non-terminally differentiated, mesoderm-derived cells that are committed to differentiate into cells of the heart. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating." [GOC:mtg_heart] is_a: BFO:0000003 is_a: GO:0060974 ! cell migration involved in heart formation intersection_of: GO:0016477 ! cell migration intersection_of: RO:0002565 CL:0002664 ! results in movement of cardioblast relationship: RO:0002565 CL:0002664 ! results in movement of cardioblast creation_date: 2009-10-15T01:52:25Z [Term] id: GO:0003272 name: endocardial cushion formation namespace: biological_process def: "The developmental process pertaining to the initial formation of an endocardial cushion. The endocardial cushion is a specialized region of mesenchymal cells that will give rise to the heart septa and valves." [GOC:mtg_heart, PMID:15797462] is_a: BFO:0000003 is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0002062 ! results in formation of anatomical entity endocardial cushion relationship: BFO:0000050 GO:0003203 ! part of endocardial cushion morphogenesis relationship: RO:0002297 UBERON:0002062 ! results in formation of anatomical entity endocardial cushion creation_date: 2009-10-20T08:53:19Z [Term] id: GO:0003273 name: cell migration involved in endocardial cushion formation namespace: biological_process def: "The orderly movement of a cell from one site to another that will contribute to the formation of an endocardial cushion. The endocardial cushion is a specialized region of mesenchymal cells that will give rise to the heart septa and valves." [GOC:mtg_heart] is_a: GO:0060973 ! cell migration involved in heart development intersection_of: GO:0016477 ! cell migration intersection_of: BFO:0000050 GO:0003272 ! part of endocardial cushion formation relationship: BFO:0000050 GO:0003272 ! part of endocardial cushion formation creation_date: 2009-10-20T09:08:44Z [Term] id: GO:0003274 name: endocardial cushion fusion namespace: biological_process def: "The cell-cell adhesion process of mesenchymal cardiac cushion cells that contributes to the process of cushion shaping." [GOC:mtg_heart] is_a: GO:0061343 ! cell adhesion involved in heart morphogenesis is_a: GO:0098609 ! cell-cell adhesion intersection_of: GO:0098609 ! cell-cell adhesion intersection_of: BFO:0000050 GO:0003203 ! part of endocardial cushion morphogenesis relationship: BFO:0000050 GO:0003203 ! part of endocardial cushion morphogenesis creation_date: 2009-10-20T09:26:32Z [Term] id: GO:0003275 name: apoptotic process involved in outflow tract morphogenesis namespace: biological_process def: "Any apoptotic process that contributes to the shaping of the outflow tract. The outflow tract is the portion of the heart through which blood flows into the arteries." [GOC:mtg_apoptosis, GOC:mtg_heart] synonym: "apoptosis involved in outflow tract morphogenesis" NARROW [] is_a: GO:0003278 ! apoptotic process involved in heart morphogenesis intersection_of: GO:0006915 ! apoptotic process intersection_of: BFO:0000050 GO:0003151 ! part of outflow tract morphogenesis relationship: BFO:0000050 GO:0003151 ! part of outflow tract morphogenesis creation_date: 2009-10-20T09:30:01Z [Term] id: GO:0003276 name: apoptotic process involved in heart valve morphogenesis namespace: biological_process def: "Any apoptotic process that contributes to the shaping of a heart valve." [GOC:mtg_apoptosis, GOC:mtg_heart] synonym: "apoptosis involved in heart valve morphogenesis" NARROW [] is_a: GO:0003278 ! apoptotic process involved in heart morphogenesis intersection_of: GO:0006915 ! apoptotic process intersection_of: BFO:0000050 GO:0003179 ! part of heart valve morphogenesis relationship: BFO:0000050 GO:0003179 ! part of heart valve morphogenesis creation_date: 2009-10-20T09:34:29Z [Term] id: GO:0003277 name: apoptotic process involved in endocardial cushion morphogenesis namespace: biological_process def: "Any apoptotic process that contributes to the shaping of an endocardial cushion. The endocardial cushion is a specialized region of mesenchymal cells that will give rise to the heart septa and valves." [GOC:mtg_apoptosis, GOC:mtg_heart] synonym: "apoptosis involved in endocardial cushion morphogenesis" NARROW [] is_a: GO:0003278 ! apoptotic process involved in heart morphogenesis intersection_of: GO:0006915 ! apoptotic process intersection_of: BFO:0000050 GO:0003203 ! part of endocardial cushion morphogenesis relationship: BFO:0000050 GO:0003203 ! part of endocardial cushion morphogenesis creation_date: 2009-10-20T09:37:03Z [Term] id: GO:0003278 name: apoptotic process involved in heart morphogenesis namespace: biological_process def: "Any apoptotic process that contributes to the shaping of the heart." [GOC:mtg_apoptosis, GOC:mtg_heart] synonym: "apoptosis involved in heart morphogenesis" NARROW [] is_a: GO:0060561 ! apoptotic process involved in morphogenesis intersection_of: GO:0006915 ! apoptotic process intersection_of: BFO:0000050 GO:0003007 ! part of heart morphogenesis relationship: BFO:0000050 GO:0003007 ! part of heart morphogenesis creation_date: 2009-10-20T09:40:22Z [Term] id: GO:0003279 name: cardiac septum development namespace: biological_process def: "The progression of a cardiac septum over time, from its initial formation to the mature structure." [GOC:mtg_heart] synonym: "heart septum development" EXACT [GOC:mtg_heart] is_a: GO:0048856 ! anatomical structure development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0002099 ! results in development of cardiac septum relationship: BFO:0000050 GO:0003205 ! part of cardiac chamber development relationship: RO:0002296 UBERON:0002099 ! results in development of cardiac septum creation_date: 2009-10-20T09:45:13Z [Term] id: GO:0003281 name: ventricular septum development namespace: biological_process def: "The progression of the ventricular septum over time from its formation to the mature structure." [GOC:mtg_heart] synonym: "interventricular septum development" EXACT [GOC:mtg_heart] synonym: "septum inferius development" NARROW [GOC:mtg_heart] is_a: GO:0003279 ! cardiac septum development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0002094 ! results in development of interventricular septum relationship: BFO:0000050 GO:0003231 ! part of cardiac ventricle development relationship: RO:0002296 UBERON:0002094 ! results in development of interventricular septum creation_date: 2009-10-20T10:04:51Z [Term] id: GO:0003283 name: atrial septum development namespace: biological_process def: "The progression of the atrial septum over time, from its initial formation to the mature structure." [GOC:mtg_heart] is_a: GO:0003279 ! cardiac septum development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0002085 ! results in development of interatrial septum relationship: BFO:0000050 GO:0003230 ! part of cardiac atrium development relationship: RO:0002296 UBERON:0002085 ! results in development of interatrial septum creation_date: 2009-10-20T10:10:38Z [Term] id: GO:0003292 name: cardiac septum cell differentiation namespace: biological_process def: "The process in which an endocardial cushion cell becomes a cell of a cardiac septum." [GOC:mtg_heart] is_a: GO:0035051 ! cardiocyte differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:2000022 ! results in acquisition of features of cardiac septum cell relationship: BFO:0000050 GO:0003279 ! part of cardiac septum development relationship: RO:0002315 CL:2000022 ! results in acquisition of features of cardiac septum cell creation_date: 2009-10-20T11:03:46Z [Term] id: GO:0003293 name: heart valve cell differentiation namespace: biological_process def: "The process in which an endocardial cushion cell give rise to a cell that is part of a heart valve." [GOC:mtg_heart] is_a: GO:0035051 ! cardiocyte differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:1000147 ! results in acquisition of features of cardiac valve cell relationship: BFO:0000050 GO:0003170 ! part of heart valve development relationship: RO:0002315 CL:1000147 ! results in acquisition of features of cardiac valve cell creation_date: 2009-10-20T11:06:46Z [Term] id: GO:0003298 name: physiological muscle hypertrophy namespace: biological_process def: "The enlargement or overgrowth of all or part of a muscle organ or tissue due to an increase in the size of its muscle cells. Physiological hypertrophy is a normal process during development." [GOC:mtg_heart] is_a: GO:0014896 ! muscle hypertrophy property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 creation_date: 2009-10-22T09:24:51Z [Term] id: GO:0003300 name: cardiac muscle hypertrophy namespace: biological_process def: "The enlargement or overgrowth of all or part of the heart muscle due to an increase in size of cardiac muscle cells without cell division." [GOC:mtg_heart] is_a: GO:0014897 ! striated muscle hypertrophy property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 creation_date: 2009-10-22T10:33:56Z [Term] id: GO:0003301 name: physiological cardiac muscle hypertrophy namespace: biological_process def: "The enlargement or overgrowth of all or part of the heart muscle due to an increase in size of cardiac muscle cells without cell division. This process contributes to the developmental growth of the heart." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:mtg_heart] is_a: GO:0003298 ! physiological muscle hypertrophy is_a: GO:0003300 ! cardiac muscle hypertrophy relationship: BFO:0000050 GO:0055017 ! part of cardiac muscle tissue growth creation_date: 2009-10-22T10:38:10Z [Term] id: GO:0003309 name: type B pancreatic cell differentiation namespace: biological_process def: "The process in which relatively unspecialized cells acquire specialized structural and/or functional features of a type B pancreatic cell. A type B pancreatic cell is a cell located towards center of the islets of Langerhans that secretes insulin." [CL:0000169, GOC:dph, PMID:11076772] synonym: "pancreatic B cell differentiation" EXACT [GOC:mah] synonym: "pancreatic beta cell differentiation" EXACT [GOC:dph] is_a: GO:0035883 ! enteroendocrine cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000169 ! results in acquisition of features of type B pancreatic cell relationship: BFO:0000050 GO:0031018 ! part of endocrine pancreas development relationship: RO:0002315 CL:0000169 ! results in acquisition of features of type B pancreatic cell creation_date: 2009-10-26T09:27:23Z [Term] id: GO:0003310 name: pancreatic A cell differentiation namespace: biological_process def: "The process in which relatively unspecialized cells acquire specialized structural and functional features of a pancreatic A cell. A pancreatic A cell is a cell in the pancreas that secretes glucagon." [GOC:dph, PMID:11076772] synonym: "pancreatic alpha cell differentiation" EXACT [GOC:dph] is_a: GO:0035883 ! enteroendocrine cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000171 ! results in acquisition of features of pancreatic A cell relationship: BFO:0000050 GO:0031018 ! part of endocrine pancreas development relationship: RO:0002315 CL:0000171 ! results in acquisition of features of pancreatic A cell creation_date: 2009-10-26T09:28:05Z [Term] id: GO:0003311 name: pancreatic D cell differentiation namespace: biological_process def: "The process in which relatively unspecialized cells acquire specialized structural and functional features that characterize a pancreatic delta cell. A delta cell is a cell of the pancreas that produces somatostatin." [GOC:dph, PMID:11076772] synonym: "pancreatic delta cell differentiation" EXACT [GOC:dph] is_a: GO:0035883 ! enteroendocrine cell differentiation is_a: GO:0061101 ! neuroendocrine cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000173 ! results in acquisition of features of pancreatic D cell relationship: BFO:0000050 GO:0031018 ! part of endocrine pancreas development relationship: RO:0002315 CL:0000173 ! results in acquisition of features of pancreatic D cell creation_date: 2009-10-26T09:30:27Z [Term] id: GO:0003312 name: pancreatic PP cell differentiation namespace: biological_process def: "The process in which relatively unspecialized cells acquire specialized structural and functional features of a pancreatic polypeptide-producing cell. A pancreatic polypeptide-producing cell is a cell in the pancreas that produces pancreatic polypeptide." [GOC:dph, PMID:11076772] synonym: "pancreatic polypeptide-producing cell differentiation" EXACT [GOC:dph] is_a: GO:0035883 ! enteroendocrine cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0002275 ! results in acquisition of features of pancreatic PP cell relationship: BFO:0000050 GO:0031018 ! part of endocrine pancreas development relationship: RO:0002315 CL:0002275 ! results in acquisition of features of pancreatic PP cell creation_date: 2009-10-26T09:32:32Z [Term] id: GO:0003313 name: heart rudiment development namespace: biological_process def: "The progression of the heart rudiment over time, from its initial formation to the mature structure. The heart rudiment is a cone-like structure that is formed when myocardial progenitor cells of the heart field fuse at the midline. The heart rudiment is the first structure of the heart tube." [GOC:mtg_heart] synonym: "heart cone development" EXACT [GOC:mtg_heart] is_a: GO:0060429 ! epithelium development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0004291 ! results in development of heart rudiment relationship: BFO:0000050 GO:0035050 ! part of embryonic heart tube development relationship: RO:0002296 UBERON:0004291 ! results in development of heart rudiment creation_date: 2009-10-27T08:32:40Z [Term] id: GO:0003314 name: heart rudiment morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the heart rudiment are generated and organized." [GOC:mtg_heart] synonym: "heart cone morphogenesis" EXACT [GOC:mtg_heart] is_a: GO:0002009 ! morphogenesis of an epithelium is_a: GO:0048598 ! embryonic morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0004291 ! results in morphogenesis of heart rudiment relationship: BFO:0000050 GO:0003007 ! part of heart morphogenesis relationship: BFO:0000050 GO:0003313 ! part of heart rudiment development relationship: RO:0002298 UBERON:0004291 ! results in morphogenesis of heart rudiment property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/22938" xsd:anyURI creation_date: 2009-10-27T08:38:04Z [Term] id: GO:0003315 name: heart rudiment formation namespace: biological_process def: "The developmental process pertaining to the initial formation of the heart rudiment." [GOC:mtg_heart] synonym: "heart cone formation" EXACT [GOC:mtg_heart] is_a: BFO:0000003 is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0004291 ! results in formation of anatomical entity heart rudiment relationship: BFO:0000050 GO:0003314 ! part of heart rudiment morphogenesis relationship: RO:0002297 UBERON:0004291 ! results in formation of anatomical entity heart rudiment creation_date: 2009-10-27T08:43:37Z [Term] id: GO:0003322 name: pancreatic A cell development namespace: biological_process def: "The process whose specific outcome is the progression of a pancreatic A cell over time, from its formation to the mature structure. A pancreatic A cell is a cell in the pancreas that secretes glucagon." [GOC:dph] synonym: "pancreatic alpha cell development" EXACT [GOC:dph] is_a: GO:0002064 ! epithelial cell development intersection_of: GO:0032502 ! developmental process intersection_of: RO:0002296 CL:0000171 ! results in development of pancreatic A cell relationship: BFO:0000050 GO:0003310 ! part of pancreatic A cell differentiation relationship: RO:0002296 CL:0000171 ! results in development of pancreatic A cell creation_date: 2009-11-02T08:13:55Z [Term] id: GO:0003323 name: type B pancreatic cell development namespace: biological_process def: "The process whose specific outcome is the progression of a type B pancreatic cell over time, from its formation to the mature structure. A type B pancreatic cell is a cell located towards center of the islets of Langerhans that secretes insulin." [CL:0000169, GOC:dph] synonym: "pancreatic B cell development" EXACT [GOC:mah] synonym: "pancreatic beta cell development" EXACT [GOC:dph] is_a: GO:0002064 ! epithelial cell development intersection_of: GO:0032502 ! developmental process intersection_of: RO:0002296 CL:0000169 ! results in development of type B pancreatic cell relationship: BFO:0000050 GO:0003309 ! part of type B pancreatic cell differentiation relationship: RO:0002296 CL:0000169 ! results in development of type B pancreatic cell creation_date: 2009-11-02T08:20:11Z [Term] id: GO:0003324 name: pancreatic D cell development namespace: biological_process def: "The process whose specific outcome is the progression of a pancreatic delta cell over time, from its formation to the mature structure. A delta cell is a cell of the pancreas that produces somatostatin." [GOC:dph] synonym: "pancreatic delta cell development" EXACT [GOC:dph] is_a: GO:0002066 ! columnar/cuboidal epithelial cell development is_a: GO:0048666 ! neuron development intersection_of: GO:0032502 ! developmental process intersection_of: RO:0002296 CL:0000173 ! results in development of pancreatic D cell relationship: BFO:0000050 GO:0003311 ! part of pancreatic D cell differentiation relationship: RO:0002296 CL:0000173 ! results in development of pancreatic D cell creation_date: 2009-11-02T08:23:26Z [Term] id: GO:0003325 name: pancreatic PP cell development namespace: biological_process def: "The process whose specific outcome is the progression of a pancreatic PP cell over time, from its formation to the mature structure. A pancreatic polypeptide-producing cell is a cell in the pancreas that produces pancreatic polypeptide." [GOC:dph] is_a: GO:0002064 ! epithelial cell development intersection_of: GO:0048468 ! cell development intersection_of: RO:0002296 CL:0002275 ! results in development of pancreatic PP cell relationship: BFO:0000050 GO:0003312 ! part of pancreatic PP cell differentiation relationship: RO:0002296 CL:0002275 ! results in development of pancreatic PP cell creation_date: 2009-11-02T08:25:03Z [Term] id: GO:0003330 name: regulation of extracellular matrix constituent secretion namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of the controlled release of molecules that form the extracellular matrix, including carbohydrates and glycoproteins by a cell or a group of cells." [GOC:dph, GOC:tb] is_a: GO:1903053 ! regulation of extracellular matrix organization is_a: GO:1903530 ! regulation of secretion by cell intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0070278 ! regulates extracellular matrix constituent secretion relationship: RO:0002211 GO:0070278 ! regulates extracellular matrix constituent secretion creation_date: 2009-11-02T02:07:40Z [Term] id: GO:0003331 name: positive regulation of extracellular matrix constituent secretion namespace: biological_process def: "Any process that increases the rate, frequency, or extent of the controlled release of molecules that form the extracellular matrix, including carbohydrates and glycoproteins by a cell or a group of cells." [GOC:dph, GOC:tb] is_a: GO:0003330 ! regulation of extracellular matrix constituent secretion is_a: GO:1903055 ! positive regulation of extracellular matrix organization is_a: GO:1903532 ! positive regulation of secretion by cell intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0070278 ! positively regulates extracellular matrix constituent secretion relationship: RO:0002213 GO:0070278 ! positively regulates extracellular matrix constituent secretion creation_date: 2009-11-02T02:11:22Z [Term] id: GO:0003332 name: negative regulation of extracellular matrix constituent secretion namespace: biological_process def: "Any process that decreases the rate, frequency, or extent the controlled release of molecules that form the extracellular matrix, including carbohydrates and glycoproteins by a cell or a group of cells." [GOC:dph, GOC:tb] is_a: GO:0003330 ! regulation of extracellular matrix constituent secretion is_a: GO:1903054 ! negative regulation of extracellular matrix organization is_a: GO:1903531 ! negative regulation of secretion by cell intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0070278 ! negatively regulates extracellular matrix constituent secretion relationship: RO:0002212 GO:0070278 ! negatively regulates extracellular matrix constituent secretion creation_date: 2009-11-02T02:13:49Z [Term] id: GO:0003333 name: amino acid transmembrane transport namespace: biological_process def: "The process in which an amino acid is transported across a membrane." [GOC:dph, GOC:tb] comment: Note that this term is not intended for use in annotating lateral movement within membranes. synonym: "amino acid membrane transport" EXACT [] is_a: GO:0006865 ! amino acid transport is_a: GO:0055085 ! transmembrane transport intersection_of: GO:0055085 ! transmembrane transport intersection_of: RO:0004009 CHEBI:35238 ! has primary input creation_date: 2009-11-02T02:36:11Z [Term] id: GO:0003334 name: keratinocyte development namespace: biological_process def: "The process whose specific outcome is the progression of a keratinocyte over time, from its formation to the mature structure." [GOC:dph] xref: Reactome:R-HSA-9725554 "Differentiation of keratinocytes in interfollicular epidermis in mammalian skin" is_a: GO:0002064 ! epithelial cell development intersection_of: GO:0032502 ! developmental process intersection_of: RO:0002296 CL:0000312 ! results in development of keratinocyte relationship: BFO:0000050 GO:0030216 ! part of keratinocyte differentiation relationship: RO:0002296 CL:0000312 ! results in development of keratinocyte creation_date: 2009-11-24T08:55:57Z [Term] id: GO:0003335 name: corneocyte development namespace: biological_process def: "The process whose specific outcome is the progression of the corneocyte over time, from its formation to the mature structure. A corneocyte is the last stage of development of a keratinocyte where the keratinocyte flattens, loses its nucleus and eventually delaminates from the epidermis." [GOC:dph] is_a: GO:0048468 ! cell development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 CL:0002153 ! results in development of corneocyte relationship: BFO:0000050 GO:0003334 ! part of keratinocyte development relationship: RO:0002296 CL:0002153 ! results in development of corneocyte creation_date: 2009-11-24T09:01:02Z [Term] id: GO:0003337 name: mesenchymal to epithelial transition involved in metanephros morphogenesis namespace: biological_process def: "A transition where a mesenchymal cell establishes apical/basolateral polarity,forms intercellular adhesive junctions, synthesizes basement membrane components and becomes an epithelial cell that will contribute to the shaping of the metanephros." [GOC:dph, GOC:yaf] synonym: "metanephric mesenchyme to epithelial transition" RELATED [GOC:dph] is_a: GO:0035850 ! epithelial cell differentiation involved in kidney development is_a: GO:0060231 ! mesenchymal to epithelial transition is_a: GO:0072202 ! cell differentiation involved in metanephros development intersection_of: GO:0060231 ! mesenchymal to epithelial transition intersection_of: BFO:0000050 GO:0003338 ! part of metanephros morphogenesis relationship: BFO:0000050 GO:0072283 ! part of metanephric renal vesicle morphogenesis creation_date: 2009-11-24T09:29:49Z [Term] id: GO:0003338 name: metanephros morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the metanephros are generated and organized." [GOC:dph, GOC:yaf] is_a: GO:0060993 ! kidney morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0000081 ! results in morphogenesis of metanephros relationship: BFO:0000050 GO:0001656 ! part of metanephros development relationship: RO:0002298 UBERON:0000081 ! results in morphogenesis of metanephros creation_date: 2009-11-24T09:32:09Z [Term] id: GO:0003339 name: regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis namespace: biological_process def: "Any process that modulates the rate, frequency or extent of the transition where a mesenchymal cell establishes apical/basolateral polarity,forms intercellular adhesive junctions, synthesizes basement membrane components and becomes an epithelial cell that will contribute to the shaping of the metanephros." [GOC:dph] is_a: GO:2000696 ! regulation of epithelial cell differentiation involved in kidney development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0003337 ! regulates mesenchymal to epithelial transition involved in metanephros morphogenesis relationship: RO:0002211 GO:0003337 ! regulates mesenchymal to epithelial transition involved in metanephros morphogenesis creation_date: 2009-11-24T09:43:04Z [Term] id: GO:0003340 name: negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis namespace: biological_process def: "Any process that decreases the rate, frequency or extent of the transition where a mesenchymal cell establishes apical/basolateral polarity,forms intercellular adhesive junctions, synthesizes basement membrane components and becomes an epithelial cell that will contribute to the shaping of the metanephros." [GOC:dph, GOC:yaf] is_a: GO:0003339 ! regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis is_a: GO:2000697 ! negative regulation of epithelial cell differentiation involved in kidney development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0003337 ! negatively regulates mesenchymal to epithelial transition involved in metanephros morphogenesis relationship: RO:0002212 GO:0003337 ! negatively regulates mesenchymal to epithelial transition involved in metanephros morphogenesis creation_date: 2009-11-24T09:46:12Z [Term] id: GO:0003341 name: cilium movement namespace: biological_process def: "The directed, self-propelled movement of a cilium." [GOC:dph, GOC:jl] comment: Note that we deem cilium and microtubule-based flagellum to be equivalent. synonym: "ciliary motility" RELATED [] synonym: "cilium beating" RELATED [GOC:ascb_2009, GOC:dph, GOC:tb] synonym: "flagellar motility" RELATED [] synonym: "flagellar movement" NARROW [GOC:bf] synonym: "flagellum movement" NARROW [] synonym: "microtubule-based flagellum movement" EXACT [] is_a: BFO:0000003 is_a: GO:0007018 ! microtubule-based movement intersection_of: GO:0007018 ! microtubule-based movement intersection_of: RO:0002565 GO:0005929 ! results in movement of cilium intersection_of: RO:0002608 GO:0005874 ! process has causal agent microtubule relationship: RO:0002162 NCBITaxon:2759 ! in taxon Eukaryota relationship: RO:0002565 GO:0005929 ! results in movement of cilium property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/19809" xsd:anyURI property_value: RO:0002161 NCBITaxon:3176 property_value: RO:0002161 NCBITaxon:3378 property_value: RO:0002161 NCBITaxon:3398 property_value: RO:0002161 NCBITaxon:4890 property_value: RO:0002161 NCBITaxon:5782 creation_date: 2009-11-24T09:56:26Z [Term] id: GO:0003342 name: proepicardium development namespace: biological_process def: "The progression of the proepicardium from its formation to the mature structure. The proepicardium is an outpouching of the septum transversum." [GOC:dph, PMID:18722343] is_a: GO:0060485 ! mesenchyme development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0004160 ! results in development of proepicardium relationship: BFO:0000050 GO:0003343 ! part of septum transversum development relationship: RO:0002296 UBERON:0004160 ! results in development of proepicardium creation_date: 2009-12-01T10:30:17Z [Term] id: GO:0003343 name: septum transversum development namespace: biological_process def: "The progression of the septum transversum from its initial formation to the mature structure. The septum transversum is a portion of the trunk mesenchyme." [GOC:dph, PMID:18722343] is_a: GO:0060485 ! mesenchyme development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0004161 ! results in development of septum transversum relationship: RO:0002296 UBERON:0004161 ! results in development of septum transversum creation_date: 2009-12-01T10:40:17Z [Term] id: GO:0003344 name: pericardium morphogenesis namespace: biological_process def: "The process in which the anatomical structure of the pericardium is generated and organized." [GOC:dph, PMID:18722343] is_a: GO:0002011 ! morphogenesis of an epithelial sheet is_a: GO:0048598 ! embryonic morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0002407 ! results in morphogenesis of pericardium relationship: BFO:0000050 GO:0060039 ! part of pericardium development relationship: RO:0002298 UBERON:0002407 ! results in morphogenesis of pericardium creation_date: 2009-12-01T10:46:34Z [Term] id: GO:0003348 name: cardiac endothelial cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of a cardiac endothelial cell." [GOC:dph, PMID:18722343] is_a: GO:0035051 ! cardiocyte differentiation is_a: GO:0045446 ! endothelial cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0010008 ! results in acquisition of features of cardiac endothelial cell relationship: RO:0002315 CL:0010008 ! results in acquisition of features of cardiac endothelial cell creation_date: 2009-12-01T11:12:05Z [Term] id: GO:0003352 name: regulation of cilium movement namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of cilium movement, the directed, self-propelled movement of a cilium." [GOC:dph] comment: Note that we deem cilium and microtubule-based flagellum to be equivalent. synonym: "regulation of flagellar movement" RELATED [GOC:TermGenie] synonym: "regulation of flagellum movement" RELATED [] synonym: "regulation of microtubule-based flagellum movement" EXACT [] is_a: GO:0060632 ! regulation of microtubule-based movement intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0003341 ! regulates cilium movement relationship: RO:0002211 GO:0003341 ! regulates cilium movement property_value: RO:0002161 NCBITaxon:3176 property_value: RO:0002161 NCBITaxon:3378 property_value: RO:0002161 NCBITaxon:3398 property_value: RO:0002161 NCBITaxon:4890 property_value: RO:0002161 NCBITaxon:5782 creation_date: 2009-12-03T10:12:00Z [Term] id: GO:0003353 name: positive regulation of cilium movement namespace: biological_process def: "Any process that increases the rate, frequency, or extent of cilium movement, the directed, self-propelled movement of a cilium." [GOC:dph] comment: Note that we deem cilium and microtubule-based flagellum to be equivalent. synonym: "positive regulation of flagellar movement" RELATED [GOC:TermGenie] synonym: "positive regulation of flagellum movement" RELATED [] synonym: "positive regulation of microtubule-based flagellum movement" EXACT [] is_a: GO:0003352 ! regulation of cilium movement is_a: GO:0048522 ! positive regulation of cellular process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0003341 ! positively regulates cilium movement relationship: RO:0002213 GO:0003341 ! positively regulates cilium movement property_value: RO:0002161 NCBITaxon:3176 property_value: RO:0002161 NCBITaxon:3378 property_value: RO:0002161 NCBITaxon:3398 property_value: RO:0002161 NCBITaxon:4890 property_value: RO:0002161 NCBITaxon:5782 creation_date: 2009-12-03T10:16:10Z [Term] id: GO:0003354 name: negative regulation of cilium movement namespace: biological_process def: "Any process that decreases the rate, frequency, or extent of cilium movement, the directed, self-propelled movement of a cilium." [GOC:dph] comment: Note that we deem cilium and microtubule-based flagellum to be equivalent. synonym: "negative regulation of flagellum movement" RELATED [] synonym: "negative regulation of microtubule-based flagellum movement" EXACT [] is_a: GO:0003352 ! regulation of cilium movement is_a: GO:0048523 ! negative regulation of cellular process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0003341 ! negatively regulates cilium movement relationship: RO:0002212 GO:0003341 ! negatively regulates cilium movement property_value: RO:0002161 NCBITaxon:3176 property_value: RO:0002161 NCBITaxon:3378 property_value: RO:0002161 NCBITaxon:3398 property_value: RO:0002161 NCBITaxon:4890 property_value: RO:0002161 NCBITaxon:5782 creation_date: 2009-12-03T10:17:47Z [Term] id: GO:0003357 name: noradrenergic neuron differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of an noradrenergic neuron, a neuron that secretes noradrenaline." [GOC:dph] synonym: "norepinephrine secreting neuron differentiation" EXACT [GOC:dph] is_a: GO:0030182 ! neuron differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0008025 ! results in acquisition of features of noradrenergic neuron relationship: RO:0002315 CL:0008025 ! results in acquisition of features of noradrenergic neuron creation_date: 2009-12-03T10:34:30Z [Term] id: GO:0003358 name: noradrenergic neuron development namespace: biological_process def: "The process whose specific outcome is the progression of a noradrenergic neuron over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell." [GOC:dph] synonym: "norepinephrine secreting neuron development" EXACT [GOC:dph] is_a: GO:0048666 ! neuron development intersection_of: GO:0032502 ! developmental process intersection_of: RO:0002296 CL:0008025 ! results in development of noradrenergic neuron relationship: BFO:0000050 GO:0003357 ! part of noradrenergic neuron differentiation relationship: RO:0002296 CL:0008025 ! results in development of noradrenergic neuron creation_date: 2009-12-03T10:38:37Z [Term] id: GO:0003360 name: brainstem development namespace: biological_process def: "The progression of the brainstem from its formation to the mature structure. The brainstem is the part of the brain that connects the brain with the spinal cord." [GOC:dph] is_a: GO:0048856 ! anatomical structure development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0002298 ! results in development of brainstem relationship: RO:0002296 UBERON:0002298 ! results in development of brainstem creation_date: 2009-12-03T10:47:20Z [Term] id: GO:0003361 name: noradrenergic neuron differentiation involved in brainstem development namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of an noradrenergic neuron that is part of the brainstem." [GOC:dph] is_a: GO:0003357 ! noradrenergic neuron differentiation intersection_of: GO:0003357 ! noradrenergic neuron differentiation intersection_of: BFO:0000050 GO:0003360 ! part of brainstem development relationship: BFO:0000050 GO:0003360 ! part of brainstem development creation_date: 2009-12-03T10:53:30Z [Term] id: GO:0003365 name: establishment of cell polarity involved in ameboidal cell migration namespace: biological_process def: "The specification and formation of anisotropic intracellular organization that contributes to the self-propelled directed movement of an ameboid cell." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0030010 ! establishment of cell polarity intersection_of: GO:0030010 ! establishment of cell polarity intersection_of: BFO:0000050 GO:0001667 ! part of ameboidal-type cell migration relationship: BFO:0000050 GO:0001667 ! part of ameboidal-type cell migration property_value: RO:0002161 NCBITaxon:4751 creation_date: 2009-12-08T04:50:41Z [Term] id: GO:0003367 name: cell-cell adhesion involved in ameboidal cell migration namespace: biological_process def: "The attachment of one ameboid cell to another that contributes to the establishment of cell polarity that is part of the directed movement of one of the cells." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0098609 ! cell-cell adhesion intersection_of: GO:0098609 ! cell-cell adhesion intersection_of: BFO:0000050 GO:0003365 ! part of establishment of cell polarity involved in ameboidal cell migration relationship: BFO:0000050 GO:0003365 ! part of establishment of cell polarity involved in ameboidal cell migration relationship: RO:0000053 PATO:0002487 ! has characteristic single organismal process quality property_value: RO:0002161 NCBITaxon:4751 creation_date: 2009-12-08T05:15:49Z [Term] id: GO:0003371 name: establishment or maintenance of cytoskeleton polarity involved in ameboidal cell migration namespace: biological_process def: "Any cellular process that results in the specification, formation or maintenance of polarized cytoskeletal structures that contribute to the cell polarity of a migrating ameboid cell." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0030952 ! establishment or maintenance of cytoskeleton polarity intersection_of: GO:0030952 ! establishment or maintenance of cytoskeleton polarity intersection_of: BFO:0000050 GO:0001667 ! part of ameboidal-type cell migration relationship: BFO:0000050 GO:0003365 ! part of establishment of cell polarity involved in ameboidal cell migration property_value: RO:0002161 NCBITaxon:4751 creation_date: 2009-12-08T05:42:46Z [Term] id: GO:0003379 name: establishment of cell polarity involved in gastrulation cell migration namespace: biological_process def: "The specification and formation of anisotropic intracellular organization that contributes to the self-propelled directed movement of an ameboid cell taking part in gastrulation." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0003365 ! establishment of cell polarity involved in ameboidal cell migration intersection_of: GO:0030010 ! establishment of cell polarity intersection_of: BFO:0000050 GO:0042074 ! part of cell migration involved in gastrulation relationship: BFO:0000050 GO:0042074 ! part of cell migration involved in gastrulation creation_date: 2009-12-09T06:54:44Z [Term] id: GO:0003380 name: establishment or maintenance of cytoskeleton polarity involved in gastrulation namespace: biological_process def: "Any cellular process that results in the specification, formation or maintenance of polarized cytoskeletal structures that contribute to the cell polarity of a migrating ameboid cell taking part in gastrulation." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0003371 ! establishment or maintenance of cytoskeleton polarity involved in ameboidal cell migration intersection_of: GO:0030952 ! establishment or maintenance of cytoskeleton polarity intersection_of: BFO:0000050 GO:0007369 ! part of gastrulation relationship: BFO:0000050 GO:0003379 ! part of establishment of cell polarity involved in gastrulation cell migration creation_date: 2009-12-09T07:10:57Z [Term] id: GO:0003381 name: epithelial cell morphogenesis involved in gastrulation namespace: biological_process def: "The change in form that occurs when an epithelial cell progresses from it initial formation to its mature state, contributing to the process of gastrulation." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0003382 ! epithelial cell morphogenesis intersection_of: GO:0003382 ! epithelial cell morphogenesis intersection_of: BFO:0000050 GO:0007369 ! part of gastrulation relationship: BFO:0000050 GO:0007369 ! part of gastrulation creation_date: 2009-12-09T07:18:53Z [Term] id: GO:0003382 name: epithelial cell morphogenesis namespace: biological_process def: "The change in form that occurs when an epithelial cell progresses from its initial formation to its mature state." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0000902 ! cell morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002299 CL:0000066 ! results in maturation of epithelial cell relationship: BFO:0000050 GO:0002064 ! part of epithelial cell development relationship: RO:0002299 CL:0000066 ! results in maturation of epithelial cell creation_date: 2009-12-09T07:21:06Z [Term] id: GO:0003403 name: optic vesicle formation namespace: biological_process def: "The developmental process pertaining to the initial formation of the optic vesicle from the lateral wall of the forebrain. This process begins with the specific processes that contribute to the appearance of the vesicle and ends when the vesicle has evaginated. The optic vesicle is the evagination of neurectoderm that precedes formation of the optic cup." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: BFO:0000003 is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0004128 ! results in formation of anatomical entity optic vesicle relationship: BFO:0000050 GO:0003404 ! part of optic vesicle morphogenesis relationship: BFO:0000050 GO:0060900 ! part of embryonic camera-type eye formation relationship: RO:0002297 UBERON:0004128 ! results in formation of anatomical entity optic vesicle creation_date: 2009-12-21T01:42:37Z [Term] id: GO:0003404 name: optic vesicle morphogenesis namespace: biological_process def: "The developmental process pertaining to the formation and shaping of the optic vesicle. This process begins with the specific processes that contribute to the appearance of the vesicle and ends when the vesicle has evaginated. The optic vesicle is the evagination of neurectoderm that precedes formation of the optic cup." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0048598 ! embryonic morphogenesis is_a: GO:0048729 ! tissue morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0004128 ! results in morphogenesis of optic vesicle relationship: BFO:0000050 GO:0048596 ! part of embryonic camera-type eye morphogenesis relationship: RO:0002298 UBERON:0004128 ! results in morphogenesis of optic vesicle creation_date: 2009-12-21T01:54:34Z [Term] id: GO:0003406 name: retinal pigment epithelium development namespace: biological_process def: "The progression of the retinal pigment epithelium over time, from its initial formation to the mature structure. The retinal pigment epithelium is the melanin-containing layer of cells between the retina and the choroid that absorbs scattered and reflected light and removes waste products produced by the photoreceptor cells." [GOC:ascb_2009, GOC:dph, GOC:tb] synonym: "RPE development" RELATED [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0060429 ! epithelium development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0001782 ! results in development of pigmented layer of retina relationship: BFO:0000050 GO:0060041 ! part of retina development in camera-type eye relationship: RO:0002296 UBERON:0001782 ! results in development of pigmented layer of retina creation_date: 2009-12-21T02:04:27Z [Term] id: GO:0003407 name: neural retina development namespace: biological_process def: "The progression of the neural retina over time from its initial formation to the mature structure. The neural retina is the part of the retina that contains neurons and photoreceptor cells." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0048856 ! anatomical structure development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0003902 ! results in development of retinal neural layer relationship: BFO:0000050 GO:0060041 ! part of retina development in camera-type eye relationship: RO:0002296 UBERON:0003902 ! results in development of retinal neural layer creation_date: 2009-12-21T02:15:14Z [Term] id: GO:0003411 name: cell motility involved in camera-type eye morphogenesis namespace: biological_process def: "Any process involved in the controlled self-propelled movement of a cell that results in translocation of the cell from one place to another and contributes to the physical shaping or formation of the camera-type eye." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0048870 ! cell motility intersection_of: GO:0048870 ! cell motility intersection_of: BFO:0000050 GO:0048593 ! part of camera-type eye morphogenesis relationship: BFO:0000050 GO:0048593 ! part of camera-type eye morphogenesis creation_date: 2009-12-21T03:04:27Z [Term] id: GO:0003413 name: chondrocyte differentiation involved in endochondral bone morphogenesis namespace: biological_process def: "The process in which a chondroblast acquires specialized structural and/or functional features of a chondrocyte that will contribute to the development of a bone. A chondrocyte is a polymorphic cell that forms cartilage." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0002062 ! chondrocyte differentiation intersection_of: GO:0002062 ! chondrocyte differentiation intersection_of: BFO:0000050 GO:0060350 ! part of endochondral bone morphogenesis relationship: BFO:0000050 GO:0060351 ! part of cartilage development involved in endochondral bone morphogenesis creation_date: 2009-12-22T08:39:58Z [Term] id: GO:0003414 name: chondrocyte morphogenesis involved in endochondral bone morphogenesis namespace: biological_process def: "The process in which the structures of a chondrocyte that will contribute to bone development are generated and organized." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0090171 ! chondrocyte morphogenesis intersection_of: GO:0090171 ! chondrocyte morphogenesis intersection_of: BFO:0000050 GO:0060350 ! part of endochondral bone morphogenesis relationship: BFO:0000050 GO:0003433 ! part of chondrocyte development involved in endochondral bone morphogenesis creation_date: 2009-12-22T08:42:55Z [Term] id: GO:0003415 name: chondrocyte hypertrophy namespace: biological_process def: "The growth of a chondrocyte, where growth contributes to the progression of the chondrocyte over time." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0048588 ! developmental cell growth relationship: BFO:0000050 GO:0002063 ! part of chondrocyte development creation_date: 2009-12-22T08:48:44Z [Term] id: GO:0003416 name: endochondral bone growth namespace: biological_process def: "The increase in size or mass of an endochondral bone that contributes to the shaping of the bone." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0098868 ! bone growth intersection_of: GO:0048589 ! developmental growth intersection_of: RO:0002343 UBERON:0002513 ! results in growth of endochondral bone relationship: RO:0002343 UBERON:0002513 ! results in growth of endochondral bone creation_date: 2009-12-22T08:52:55Z [Term] id: GO:0003417 name: growth plate cartilage development namespace: biological_process def: "The process whose specific outcome is the progression of the cartilage that will provide a scaffold for mineralization of endochondral bones as they elongate or grow." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0060351 ! cartilage development involved in endochondral bone morphogenesis is_a: GO:0061448 ! connective tissue development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0004129 ! results in development of growth plate cartilage relationship: BFO:0000050 GO:0003416 ! part of endochondral bone growth relationship: RO:0002296 UBERON:0004129 ! results in development of growth plate cartilage creation_date: 2009-12-22T08:57:42Z [Term] id: GO:0003418 name: growth plate cartilage chondrocyte differentiation namespace: biological_process def: "The process in which a chondroblast acquires specialized structural and/or functional features of a chondrocyte that will contribute to the growth of a bone. A chondrocyte is a polymorphic cell that forms cartilage." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0003413 ! chondrocyte differentiation involved in endochondral bone morphogenesis intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:1000217 ! results in acquisition of features of growth plate cartilage chondrocyte relationship: BFO:0000050 GO:0003417 ! part of growth plate cartilage development relationship: RO:0002315 CL:1000217 ! results in acquisition of features of growth plate cartilage chondrocyte creation_date: 2009-12-22T09:00:56Z [Term] id: GO:0003422 name: growth plate cartilage morphogenesis namespace: biological_process def: "The process in which the anatomical structures of growth plate cartilage are generated and organized." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0060536 ! cartilage morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0004129 ! results in morphogenesis of growth plate cartilage relationship: BFO:0000050 GO:0003417 ! part of growth plate cartilage development relationship: RO:0002298 UBERON:0004129 ! results in morphogenesis of growth plate cartilage creation_date: 2009-12-22T09:21:30Z [Term] id: GO:0003429 name: growth plate cartilage chondrocyte morphogenesis namespace: biological_process def: "The process in which the structures of a chondrocyte in the growth plate cartilage are generated and organized." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0003414 ! chondrocyte morphogenesis involved in endochondral bone morphogenesis is_a: GO:0003422 ! growth plate cartilage morphogenesis intersection_of: GO:0090171 ! chondrocyte morphogenesis intersection_of: RO:0002298 UBERON:0004129 ! results in morphogenesis of growth plate cartilage relationship: BFO:0000050 GO:0003418 ! part of growth plate cartilage chondrocyte differentiation creation_date: 2009-12-22T12:22:24Z [Term] id: GO:0003430 name: growth plate cartilage chondrocyte growth namespace: biological_process def: "The growth of a growth plate cartilage chondrocyte, where growth contributes to the progression of the chondrocyte over time from one condition to another." [GOC:ascb_2009, GOC:dph, GOC:tb] synonym: "growth plate cartilage chondrocyte hypertrophy" EXACT [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0003415 ! chondrocyte hypertrophy is_a: GO:0060560 ! developmental growth involved in morphogenesis intersection_of: GO:0040007 ! growth intersection_of: RO:0002343 CL:1000217 ! results in growth of growth plate cartilage chondrocyte relationship: BFO:0000050 GO:0003431 ! part of growth plate cartilage chondrocyte development relationship: RO:0002343 CL:1000217 ! results in growth of growth plate cartilage chondrocyte creation_date: 2009-12-22T12:29:19Z [Term] id: GO:0003431 name: growth plate cartilage chondrocyte development namespace: biological_process def: "The progression of a growth plate cartilage chondrocyte over time from after its fate commitment to the mature cell." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0003433 ! chondrocyte development involved in endochondral bone morphogenesis intersection_of: GO:0048468 ! cell development intersection_of: RO:0002296 CL:1000217 ! results in development of growth plate cartilage chondrocyte relationship: BFO:0000050 GO:0003418 ! part of growth plate cartilage chondrocyte differentiation relationship: RO:0002296 CL:1000217 ! results in development of growth plate cartilage chondrocyte creation_date: 2009-12-22T12:32:49Z [Term] id: GO:0003432 name: cell growth involved in growth plate cartilage chondrocyte morphogenesis namespace: biological_process def: "The growth of a growth plate cartilage chondrocyte, where growth contributes to the shaping of the chondrocyte over time." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0003430 ! growth plate cartilage chondrocyte growth intersection_of: GO:0048588 ! developmental cell growth intersection_of: BFO:0000050 GO:0003429 ! part of growth plate cartilage chondrocyte morphogenesis relationship: BFO:0000050 GO:0003429 ! part of growth plate cartilage chondrocyte morphogenesis creation_date: 2009-12-22T12:37:48Z [Term] id: GO:0003433 name: chondrocyte development involved in endochondral bone morphogenesis namespace: biological_process def: "The progression of a chondrocyte over time from after its commitment to its mature state where the chondrocyte will contribute to the shaping of an endochondral bone." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0002063 ! chondrocyte development intersection_of: GO:0002063 ! chondrocyte development intersection_of: BFO:0000050 GO:0060350 ! part of endochondral bone morphogenesis relationship: BFO:0000050 GO:0003413 ! part of chondrocyte differentiation involved in endochondral bone morphogenesis creation_date: 2009-12-22T12:42:44Z [Term] id: GO:0003436 name: regulation of cell adhesion involved in growth plate cartilage morphogenesis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of attachment of a cell to another cell or to the extracellular matrix and contributes to the shaping of the growth plate cartilage of an endochondral bone." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0030155 ! regulation of cell adhesion intersection_of: GO:0030155 ! regulation of cell adhesion intersection_of: BFO:0000050 GO:0003422 ! part of growth plate cartilage morphogenesis relationship: BFO:0000050 GO:0003422 ! part of growth plate cartilage morphogenesis creation_date: 2009-12-22T01:28:15Z [Term] id: GO:0003437 name: regulation of cell communication involved in growth plate cartilage morphogenesis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cell communication that contributes to the shaping of the growth plate cartilage." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0010646 ! regulation of cell communication intersection_of: GO:0010646 ! regulation of cell communication intersection_of: BFO:0000050 GO:0003422 ! part of growth plate cartilage morphogenesis relationship: BFO:0000050 GO:0003422 ! part of growth plate cartilage morphogenesis creation_date: 2009-12-22T01:34:24Z [Term] id: GO:0003674 name: molecular_function namespace: molecular_function def: "A molecular process that can be carried out by the action of a single macromolecular machine, usually via direct physical interactions with other molecular entities. Function in this sense denotes an action, or activity, that a gene product (or a complex) performs." [GOC:pdt] comment: Note that, in addition to forming the root of the molecular function ontology, this term is recommended for the annotation of gene products whose molecular function is unknown. When this term is used for annotation, it indicates that no information was available about the molecular function of the gene product annotated as of the date the annotation was made; the evidence code 'no data' (ND), is used to indicate this. Despite its name, this is not a type of 'function' in the sense typically defined by upper ontologies such as Basic Formal Ontology (BFO). It is instead a BFO:process carried out by a single gene product or complex. subset: goslim_candida subset: goslim_chembl subset: goslim_metagenomics subset: goslim_pir subset: goslim_plant subset: goslim_yeast synonym: "molecular function" EXACT [] is_a: BFO:0000015 disjoint_from: GO:0005575 ! cellular_component disjoint_from: GO:0008150 ! biological_process [Term] id: GO:0003676 name: nucleic acid binding namespace: molecular_function def: "Binding to a nucleic acid." [GOC:jl] subset: goslim_chembl subset: goslim_metagenomics subset: goslim_pir subset: goslim_plant synonym: "base pairing" NARROW [] is_a: BFO:0000003 is_a: GO:0005488 ! binding intersection_of: GO:0005488 ! binding intersection_of: RO:0004009 CHEBI:33696 ! has primary input relationship: RO:0004009 CHEBI:33696 ! has primary input [Term] id: GO:0003677 name: DNA binding namespace: molecular_function def: "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] subset: goslim_agr subset: goslim_candida subset: goslim_chembl subset: goslim_drosophila subset: goslim_euk_cellular_processes_ribbon subset: goslim_flybase_ribbon subset: goslim_generic subset: goslim_mouse subset: goslim_plant subset: goslim_plant_ribbon subset: goslim_prokaryote subset: goslim_prokaryote_ribbon subset: goslim_yeast synonym: "microtubule/chromatin interaction" RELATED [] synonym: "plasmid binding" NARROW [] synonym: "structure specific DNA binding" RELATED [] synonym: "structure-specific DNA binding" RELATED [] is_a: GO:0003676 ! nucleic acid binding intersection_of: GO:0005488 ! binding intersection_of: RO:0004009 CHEBI:16991 ! has primary input relationship: RO:0004009 CHEBI:16991 ! has primary input [Term] id: GO:0003682 name: chromatin binding namespace: molecular_function def: "Binding to chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase." [GOC:jl, ISBN:0198506732, PMID:20404130] subset: goslim_chembl subset: goslim_drosophila subset: goslim_pir subset: goslim_plant subset: goslim_yeast synonym: "lamin/chromatin binding" NARROW [] synonym: "microtubule/chromatin interaction" NARROW [] synonym: "nuclear membrane vesicle binding to chromatin" NARROW [] is_a: BFO:0000003 is_a: GO:0005488 ! binding intersection_of: GO:0005488 ! binding intersection_of: RO:0004009 GO:0000785 ! has primary input chromatin relationship: RO:0004009 GO:0000785 ! has primary input chromatin [Term] id: GO:0003723 name: RNA binding namespace: molecular_function def: "Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah] subset: goslim_agr subset: goslim_candida subset: goslim_chembl subset: goslim_drosophila subset: goslim_euk_cellular_processes_ribbon subset: goslim_flybase_ribbon subset: goslim_generic subset: goslim_mouse subset: goslim_plant subset: goslim_plant_ribbon subset: goslim_prokaryote subset: goslim_prokaryote_ribbon subset: goslim_yeast synonym: "base pairing with RNA" NARROW [] synonym: "poly(A) RNA binding" RELATED [] synonym: "poly(A)-RNA binding" RELATED [] synonym: "poly-A RNA binding" RELATED [] xref: Reactome:R-HSA-203922 "Exportin-5 recognizes 3' overhang of pre-miRNA" is_a: GO:0003676 ! nucleic acid binding intersection_of: GO:0005488 ! binding intersection_of: RO:0004009 CHEBI:33697 ! has primary input relationship: RO:0004009 CHEBI:33697 ! has primary input [Term] id: GO:0003774 name: cytoskeletal motor activity namespace: molecular_function def: "Generation of force resulting in movement, for example along a microfilament or microtubule, or in torque resulting in membrane scission or rotation of a flagellum. The energy required is obtained either from the hydrolysis of a nucleoside triphosphate or by an electrochemical proton gradient (proton-motive force)." [GOC:mah, GOC:vw, PMID:11242086, PMID:29716949] subset: goslim_candida subset: goslim_euk_cellular_processes_ribbon subset: goslim_generic subset: goslim_pir subset: goslim_plant subset: goslim_plant_ribbon subset: goslim_prokaryote subset: goslim_prokaryote_ribbon synonym: "motor activity" BROAD [] xref: Reactome:R-HSA-1861595 "Extension of pseudopodia by myosin-X in a PI3K dependent manner" is_a: GO:0003674 ! molecular_function property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/19590" xsd:anyURI property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/21756" xsd:anyURI [Term] id: GO:0003777 name: microtubule motor activity namespace: molecular_function def: "A motor activity that generates movement along a microtubule, driven by ATP hydrolysis." [PMID:19686686, PMID:32684327, PMID:32842864] comment: Consider also annotating to the molecular function term 'microtubule binding ; GO:0008017'. synonym: "ATP-dependent microtubule motor activity" EXACT [] synonym: "axonemal motor activity" NARROW [] synonym: "dynein" BROAD [] synonym: "dynein ATPase activity" NARROW [] synonym: "kinesin" BROAD [] synonym: "kinesin motor activity" NARROW [] synonym: "kinetochore motor activity" NARROW [] xref: Reactome:R-HSA-177479 "Axonal transport of NGF:Trk complexes" xref: Reactome:R-HSA-265160 "Insulin secretory granule translocates to cell cortex" xref: Reactome:R-HSA-9610627 "KIF17 transports GluN1:GluN2B (GRIN1:GRIN2B) NMDA receptors to the plasma membrane" is_a: GO:0003774 ! cytoskeletal motor activity is_a: GO:0120544 ! polypeptide conformation or assembly isomerase activity is_a: GO:0140657 ! ATP-dependent activity intersection_of: GO:0003774 ! cytoskeletal motor activity intersection_of: has_participant GO:0005874 ! microtubule relationship: has_participant GO:0005874 ! microtubule property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/18664" xsd:anyURI property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/29690" xsd:anyURI creation_date: 2016-04-04T10:59:42Z [Term] id: GO:0003824 name: catalytic activity namespace: molecular_function def: "Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732] subset: goslim_agr subset: goslim_chembl subset: goslim_euk_cellular_processes_ribbon subset: goslim_flybase_ribbon subset: goslim_generic subset: goslim_metagenomics subset: goslim_pir subset: goslim_plant subset: goslim_plant_ribbon subset: goslim_prokaryote_ribbon synonym: "enzyme activity" EXACT [GOC:dph, GOC:tb] xref: Wikipedia:Enzyme is_a: GO:0003674 ! molecular_function [Term] id: GO:0004518 name: nuclease activity namespace: molecular_function def: "Catalysis of the cleavage of ester linkages within nucleic acids." [ISBN:0198547684] comment: Most nucleases are classed as hydrolases, though a minority are classed as lyases. subset: goslim_chembl subset: goslim_drosophila subset: goslim_plant subset: goslim_yeast is_a: GO:0140640 ! catalytic activity, acting on a nucleic acid property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/24408" xsd:anyURI [Term] id: GO:0004536 name: DNA nuclease activity namespace: molecular_function def: "Catalysis of the cleavage of ester linkages within deoxyribonucleic acid." [GOC:mah, ISBN:0198547684] synonym: "caspase-activated deoxyribonuclease activity" NARROW [] synonym: "deoxyribonuclease activity" EXACT [] xref: Reactome:R-HSA-211247 "Cleavage of DNA by DFF40" xref: Reactome:R-HSA-5685994 "Long-range resection of DNA DSBs by EXO1 or DNA2" xref: Reactome:R-HSA-6785986 "DNA nucleases unhook the interstrand crosslink (ICL)" is_a: GO:0004518 ! nuclease activity is_a: GO:0140097 ! catalytic activity, acting on DNA relationship: BFO:0000050 GO:0006259 ! part of DNA metabolic process property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/24408" xsd:anyURI [Term] id: GO:0004672 name: protein kinase activity namespace: molecular_function def: "Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [PMID:25399640] comment: Note that triphosphate is used as a phosphate donor by at least one kinase. subset: goslim_candida synonym: "protamine kinase activity" NARROW [] xref: Reactome:R-HSA-156832 "INF-gamma induced phosphorylation of L13a" xref: Reactome:R-HSA-5693148 "BCKDK phosphorylates BCKDH" xref: Reactome:R-HSA-937034 "IRAK1 phosphorylates Pellino" xref: Reactome:R-HSA-9604606 "Unknown kinase phosphorylates NICD4" xref: Reactome:R-HSA-9673284 "GTP-bound RAC1 contributes to MAPK8 activation" xref: Reactome:R-HSA-9732753 "JAK1-activated RAF1 phosphorylates MAPKs" xref: Reactome:R-HSA-975139 "IRAK1 phosphorylates Pellino upon TLR7/8 or 9 activation" xref: Reactome:R-HSA-9833820 "PKR dimer autophosphorylates" xref: Reactome:R-HSA-9835885 "p-PKR dimer phosphorylates eIF2-alpha" xref: Reactome:R-HSA-9836159 "p-PKR dimer phosphorylates DHX9" xref: Reactome:R-HSA-9836184 "p-PKR dimer phosphorylates CDK1" xref: Reactome:R-HSA-9836322 "p-PKR dimer phosphorylates MKK6" xref: Reactome:R-HSA-9836362 "p-PKR dimer phosphorylates TP53 tetramer" xref: Reactome:R-HSA-9836383 "p-PKR dimer phosphorylates ILF3:ILF2" xref: Reactome:R-HSA-9836404 "p-PKR dimer phosphorylates MAPT" xref: Reactome:R-HSA-9836435 "p-PKR dimer phosphorylates SNCA" xref: Reactome:R-HSA-9836449 "p-PKR dimer phosphorylates HIV tat" xref: Reactome:R-HSA-9836515 "p-PKR dimer phosphorylates PTPN2" xref: Reactome:R-HSA-9836617 "p-PKR dimer phosphorylates SPHK1" xref: Reactome:R-HSA-9836664 "p-PKR dimer phosphorylates PPP2R5A" is_a: GO:0016301 ! kinase activity is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor is_a: GO:0140096 ! catalytic activity, acting on a protein [Term] id: GO:0004713 name: protein tyrosine kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [RHEA:10596] synonym: "protein-tyrosine kinase activity" EXACT [] xref: EC:2.7.10.- {source="skos:exactMatch"} xref: MetaCyc:2.7.10.1-RXN xref: Reactome:R-HSA-112333 "SRC autophosphorylation is positively regulated by InlA-bound CDH1" xref: Reactome:R-HSA-114600 "Fyn/Lyn-mediated phosphorylation of FcR1 gamma" xref: Reactome:R-HSA-1168394 "STAT5 tyrosine phosphorylation" xref: Reactome:R-HSA-1169421 "Trans-autophosphorylation of activated ligand-responsive EGFR mutant dimers" xref: Reactome:R-HSA-1225952 "Phosphorylation of SHC1 by ligand-responsive p-6Y-EGFR mutants" xref: Reactome:R-HSA-1225960 "Phosphorylation of CBL by ligand-responsive p-6Y-EGFR mutants" xref: Reactome:R-HSA-1247844 "Phosphorylation of PLCG1 by ligand-responsive p-6Y-EGFR mutants" xref: Reactome:R-HSA-1248655 "Trans-autophosphorylation of EGFRvIII mutant dimers" xref: Reactome:R-HSA-1248694 "Trans-autophosphorylation of ERBB2 homodimer" xref: Reactome:R-HSA-1250195 "SHC1 phosphorylation by ERBB2 heterodimers" xref: Reactome:R-HSA-1250315 "Trans-autophosphorylation of ERBB4 homodimers" xref: Reactome:R-HSA-1250348 "Phosphorylation of SHC1 by ERBB4 homodimers" xref: Reactome:R-HSA-1251922 "PLCG1 phosphorylation by p-EGFR:p-ERBB2" xref: Reactome:R-HSA-1295540 "IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3:STAT5A,STAT5B phosphorylates STAT5" xref: Reactome:R-HSA-1295609 "SRC phosphorylates SPRY2 on Y55 and Y227" xref: Reactome:R-HSA-1307963 "Autocatalytic phosphorylation of BetaKlotho-bound FGFR4" xref: Reactome:R-HSA-1433418 "Phosphorylation of JAK2" xref: Reactome:R-HSA-1433454 "Phosphorylation of GAB2 by SFKs" xref: Reactome:R-HSA-1433488 "Phosphorylation of SHP2 by SFKs" xref: Reactome:R-HSA-1433506 "Phosphorylation of APS" xref: Reactome:R-HSA-1433542 "Phosphorylation and activation of VAV1" xref: Reactome:R-HSA-1470009 "Phosphorylation of STATs" xref: Reactome:R-HSA-1472121 "Phosphorylation of p-KIT on Y900 by Src kinases" xref: Reactome:R-HSA-1524186 "Phosphorylation of PLCgamma by PDGFR" xref: Reactome:R-HSA-1671691 "PRLR-bound STAT5 is phosphorylated" xref: Reactome:R-HSA-170070 "Wee1-mediated phosphorylation of Cyclin B1:phospho-Cdc2 complexes" xref: Reactome:R-HSA-170156 "WEE1 phosphorylates CCNA:CDK1" xref: Reactome:R-HSA-170991 "SRC-1 autophosphorylates" xref: Reactome:R-HSA-171011 "Binding and activation of MAP Kinase" xref: Reactome:R-HSA-174164 "Phosphorylation of Cyclin A:Cdk2 at Tyr 15" xref: Reactome:R-HSA-177934 "EGFR autophosphorylation" xref: Reactome:R-HSA-177937 "Phosphorylation of EGFR by SRC kinase" xref: Reactome:R-HSA-182969 "Phosphorylation of CBL (EGFR:CBL)" xref: Reactome:R-HSA-183058 "Phosphorylation of CBL (EGFR:GRB2:CBL)" xref: Reactome:R-HSA-1839065 "Phosphorylation of cytosolic FGFR1 fusion dimers" xref: Reactome:R-HSA-1839067 "Phosphorylation of BCR moiety of BCR-FGFR1" xref: Reactome:R-HSA-1839098 "Activated FGFR1 mutants and fusions phosphorylate PLCG1" xref: Reactome:R-HSA-1839110 "p-BCR-p-FGFR1 phosphorylates GAB2" xref: Reactome:R-HSA-1839112 "Phosphorylation of STAT5 by cytosolic FGFR1 fusions" xref: Reactome:R-HSA-186786 "Autophosphorylation of PDGF beta receptors" xref: Reactome:R-HSA-1888198 "FGFR1OP-FGFR1 phosphorylates STAT1 and STAT3" xref: Reactome:R-HSA-190326 "Autocatalytic phosphorylation of FGFR4" xref: Reactome:R-HSA-190385 "Autocatalytic phosphorylation of FGFR3b" xref: Reactome:R-HSA-190388 "Autocatalytic phosphorylation of FGFR3c" xref: Reactome:R-HSA-190408 "Autocatalytic phosphorylation of FGFR2b" xref: Reactome:R-HSA-190413 "Autocatalytic phosphorylation of FGFR2c" xref: Reactome:R-HSA-190427 "Autocatalytic phosphorylation of FGFR1b" xref: Reactome:R-HSA-190429 "Autocatalytic phosphorylation of FGFR1c" xref: Reactome:R-HSA-191062 "Autocatalytic phosphorylation of Klotho-bound FGFR1c" xref: Reactome:R-HSA-191636 "Phosphorylation of Cx43 by c-src" xref: Reactome:R-HSA-1963581 "Trans-autophosphorylation of p-Y877-ERBB2 heterodimers" xref: Reactome:R-HSA-1963582 "Trans-autophosphorylation of ERBB2 heterodimers" xref: Reactome:R-HSA-1963586 "SRC family kinases phosphorylate ERBB2" xref: Reactome:R-HSA-1982066 "Ligand-independent phosphorylation of overexpressed FGFR1" xref: Reactome:R-HSA-2012073 "Autocatalytic phosphorylation of FGFR3c P250R mutant" xref: Reactome:R-HSA-2012082 "Autocatalytic phosphorylation of FGFR3 cysteine mutants" xref: Reactome:R-HSA-2012087 "Autocatalytic phosphorylation of FGFR4 Y367C mutant" xref: Reactome:R-HSA-201521 "ALK autophosphorylation" xref: Reactome:R-HSA-202165 "Phosphorylation of ITAM motifs in CD3 complexes" xref: Reactome:R-HSA-202168 "Phosphorylation of ZAP-70 by Lck" xref: Reactome:R-HSA-202174 "Activation of ZAP-70" xref: Reactome:R-HSA-202216 "Phosphorylation of SLP-76" xref: Reactome:R-HSA-202233 "Inactivation of Lck by Csk" xref: Reactome:R-HSA-202245 "Phosphorylation of TBSMs in LAT" xref: Reactome:R-HSA-202248 "Phosphorylation of PLC-gamma1" xref: Reactome:R-HSA-202291 "Activation of Lck" xref: Reactome:R-HSA-202307 "Change of PKC theta conformation" xref: Reactome:R-HSA-2023455 "Autocatalytic phosphorylation of FGFR1c P252X mutant dimers" xref: Reactome:R-HSA-2023460 "Autocatalytic phosphorylation of FGFR1 mutants with enhanced kinase activity" xref: Reactome:R-HSA-2029268 "Phosphorylation and activation of PLCG" xref: Reactome:R-HSA-2029449 "Phosphorylation of SYK by Src kinases" xref: Reactome:R-HSA-2029453 "Phosphorylation of VAV" xref: Reactome:R-HSA-2029459 "Sequestering and phosphorylation Fc gamma receptors in the lipid rafts" xref: Reactome:R-HSA-2029984 "Autocatalytic phosphorylation of FGFR2 ligand-independent mutants" xref: Reactome:R-HSA-2029989 "Autocatalytic phosphorylation of overexpressed FGFR2 variants" xref: Reactome:R-HSA-2033485 "Autocatalytic phosphorylation of FGFR3 point mutants with enhanced kinase activity" xref: Reactome:R-HSA-2033486 "Autocatalytic phosphorylation of FGFR2c mutants with enhanced ligand binding" xref: Reactome:R-HSA-2033488 "Autocatalytic phosphorylation of FGFR2b mutants with enhanced ligand binding" xref: Reactome:R-HSA-2033490 "Autocatalytic phosphorylation of FGFR2 point mutants with enhanced kinase activity" xref: Reactome:R-HSA-2038387 "Autocatalytic phosphorylation of FGFR3 t(4;14) translocation mutants" xref: Reactome:R-HSA-2038944 "Autocatalytic phosphorylation of FGFR4 mutants with enhanced kinase activity" xref: Reactome:R-HSA-205289 "Autophosphorylation of KIT" xref: Reactome:R-HSA-210291 "Phosphorylation of PECAM-1 by Fyn or Lyn or c-Src" xref: Reactome:R-HSA-210872 "Trans-phosphorylation of Tie2" xref: Reactome:R-HSA-212710 "EGFR activates PLC-gamma1 by phosphorylation" xref: Reactome:R-HSA-2130194 "ABL phosphorylates WAVEs" xref: Reactome:R-HSA-2197698 "Src phosphorylate WASP,N-WASP" xref: Reactome:R-HSA-2201322 "TIRAP is phosphorylated by BTK" xref: Reactome:R-HSA-2395412 "Phosphorylation of SYK" xref: Reactome:R-HSA-2395439 "Phosphorylation of DAP12" xref: Reactome:R-HSA-2395801 "Phosphorylation of LAT by p-SYK" xref: Reactome:R-HSA-2396594 "Phosphorylation of SLP-76 by p-SYK" xref: Reactome:R-HSA-2404193 "IGF1R phosphorylates SHC1" xref: Reactome:R-HSA-2404199 "IGF1,2:IGF1R autophosphorylates" xref: Reactome:R-HSA-2424484 "Phosphorylation of BTK by p-SYK" xref: Reactome:R-HSA-2424486 "Phosphorylation and activation of VAV2/VAV3 by SYK" xref: Reactome:R-HSA-2424487 "Phosphorylation of PLC-gamma by p-BTK/p-SYK" xref: Reactome:R-HSA-2428926 "IGF1,2:p-Y1161,1165,1166-IGF1R phosphorylates IRS1,2,4" xref: Reactome:R-HSA-2454208 "Phosphorylation of beta and gamma subunits by LYN" xref: Reactome:R-HSA-2454239 "Phosphorylation of SYK" xref: Reactome:R-HSA-2586553 "JAK2 Phosphorylates LEPR" xref: Reactome:R-HSA-2586555 "JAK2 Autophosphorylates in Response to Leptin" xref: Reactome:R-HSA-2671742 "JAK2 Phosphorylates SHP2 (PTPN11) in Response to Leptin" xref: Reactome:R-HSA-2671829 "JAK2 Phosphorylates STAT5 in Response to Leptin" xref: Reactome:R-HSA-2671850 "JAK2 Phosphoryates STAT3 in Response to Leptin" xref: Reactome:R-HSA-2730833 "Phosphorylation of TEC kinases by p-SYK" xref: Reactome:R-HSA-2730843 "Phosphorylation of LAT by p-SYK" xref: Reactome:R-HSA-2730851 "Phosphorylation of SLP-76 by p-SYK" xref: Reactome:R-HSA-2730858 "Autophosphorylation of BTK/ITK" xref: Reactome:R-HSA-2730860 "Phosphorylation of GAB2 by SYK/FYN" xref: Reactome:R-HSA-2730862 "Autophosphorylation of LYN kinase" xref: Reactome:R-HSA-2730882 "Phosphorylation of PKC-theta" xref: Reactome:R-HSA-2730884 "Phosphorylation of NTAL by p-SYK/Lyn" xref: Reactome:R-HSA-2730886 "Phosphorylation of SHC by SYK kinase" xref: Reactome:R-HSA-2730888 "Phosphorylation of PLC-gamma" xref: Reactome:R-HSA-3215391 "PRMT5 is tyrosine phosphorylated by JAK2 V617F" xref: Reactome:R-HSA-354073 "Autophosphorylation of PTK2 at Y397" xref: Reactome:R-HSA-354124 "Phosphorylation of pPTK2 by SRC" xref: Reactome:R-HSA-372693 "Phosphorylation of BCAR1 by SRC-PTK2 complex" xref: Reactome:R-HSA-373747 "Phosphorylation of nephrin by FYN" xref: Reactome:R-HSA-373750 "SEMA4D interacts with Plexin-B1:ErbB2" xref: Reactome:R-HSA-374701 "Phosphorylation of DCC by Fyn" xref: Reactome:R-HSA-377640 "Autophosphorylation of SRC" xref: Reactome:R-HSA-380780 "Activation of Src" xref: Reactome:R-HSA-388831 "Phosphorylation of CD28" xref: Reactome:R-HSA-388833 "Phosphorylation of CTLA-4" xref: Reactome:R-HSA-389083 "Autophosphorylation of PDGF alpha receptors" xref: Reactome:R-HSA-389086 "Autophosphorylation of PDGF alpha/beta receptors" xref: Reactome:R-HSA-389159 "CSF1R trans-autophosphorylates on multiple tyrosine and serine residues" xref: Reactome:R-HSA-389354 "Activation of Vav1" xref: Reactome:R-HSA-389762 "Phosphorylation of PD-1" xref: Reactome:R-HSA-391156 "Phosphorylation of ITIM motif in SIRP alpha" xref: Reactome:R-HSA-391865 "Recruitment of FAK to NCAM1:Fyn in lipid rafts" xref: Reactome:R-HSA-391866 "Phosphorylation of FAK by Src kinase" xref: Reactome:R-HSA-391871 "Autophosphorylation of NCAM1 bound Fyn" xref: Reactome:R-HSA-3928578 "EPH receptors autophosphorylate" xref: Reactome:R-HSA-3928580 "SFKs phosphorylate EFNBs" xref: Reactome:R-HSA-3928583 "FYN phosphorylates NMDAR2B" xref: Reactome:R-HSA-3928594 "SFKs phosphorylate GIT1" xref: Reactome:R-HSA-3928604 "SFKs phosphorylate VAV2,3" xref: Reactome:R-HSA-3928610 "PTK2 autophosphorylates at Y397" xref: Reactome:R-HSA-3928627 "EPHB phosphorylates TIAM1" xref: Reactome:R-HSA-3928648 "SFKs phosphorylate NGEF" xref: Reactome:R-HSA-399934 "Phosphorylation of Plexin-A" xref: Reactome:R-HSA-399946 "Recruitment and activation of Cdk5" xref: Reactome:R-HSA-399947 "Tyrosine phosphorylation of CRMPs by Fes" xref: Reactome:R-HSA-4093332 "p-EPHB phosphorylates SDC2" xref: Reactome:R-HSA-418163 "Activated SRC-1 activates MAPKs (in F2R:ARRB1:MAPKs:active SRC-1)" xref: Reactome:R-HSA-418859 "Phosphorylation of Unc5C" xref: Reactome:R-HSA-418872 "Phosphorylation of FADK1" xref: Reactome:R-HSA-419646 "SEMA4D interacts with Plexin-B1:Met" xref: Reactome:R-HSA-428888 "Phosphorylation of ROBO1 by ABL kinase" xref: Reactome:R-HSA-429441 "SYK activation by SRC" xref: Reactome:R-HSA-429449 "Syk activation leads to SLP-76 activation" xref: Reactome:R-HSA-432129 "FGR binds and phosphorylates LRP8" xref: Reactome:R-HSA-434836 "Syk/Lck phosphorylate LAT" xref: Reactome:R-HSA-4420117 "VEGFR2 autophosphorylates" xref: Reactome:R-HSA-4420121 "SFKs phosphorylate PLCG1" xref: Reactome:R-HSA-4420128 "SRC-1 phosphorylates SHB" xref: Reactome:R-HSA-4420206 "Phosphorylation of SRC-1" xref: Reactome:R-HSA-443817 "Phosphorylation of L1 by EPHB2" xref: Reactome:R-HSA-445076 "Phosphorylation of Y1229 in L1" xref: Reactome:R-HSA-445084 "Phosphorylation of L1 by SRC" xref: Reactome:R-HSA-445085 "Phosphorylation of VAV2" xref: Reactome:R-HSA-445091 "Phosphorylation of Neurofascin" xref: Reactome:R-HSA-451942 "Within the IL-2R complex JAK3 phosphorylates JAK1" xref: Reactome:R-HSA-452097 "Recruited STAT5 is phosphorylated" xref: Reactome:R-HSA-452100 "SHC1 bound to IL2 receptor is phosphorylated" xref: Reactome:R-HSA-452122 "JAK1 phosphorylates Y338, Y392 and Y510 of IL2RB" xref: Reactome:R-HSA-508282 "SYK is a substrate for JAK1" xref: Reactome:R-HSA-5218640 "SRC-1 phosphorylates p-Y397-PTK2" xref: Reactome:R-HSA-5218642 "PTK2 autophosphorylates" xref: Reactome:R-HSA-5218806 "FYN autophosphorylates" xref: Reactome:R-HSA-5218809 "PTK2 and SRC-1 phosphorylate PXN on Y31 and Y118" xref: Reactome:R-HSA-5218812 "FYN phosphorylates PAK2" xref: Reactome:R-HSA-5218820 "Src kinases phosphorylate VAV" xref: Reactome:R-HSA-5218828 "PTK2/SRC-1 phosphorylates BCAR1" xref: Reactome:R-HSA-5218830 "SRC-1 phosphorylates PTK2-beta" xref: Reactome:R-HSA-5218851 "p-Y402-PTK2B phosphorylates p-5Y,S732-PTK2 on Y407" xref: Reactome:R-HSA-5357429 "AXL autophosphorylates on Y779 and Y821" xref: Reactome:R-HSA-5607745 "1,3-beta-D-glucan:p-Y15-CLEC7A:SYK phosphorylates PLCG" xref: Reactome:R-HSA-5607750 "SRC kinase phosphorylates CLEC7A:1,3-beta-D-glucan" xref: Reactome:R-HSA-5621355 "LYN and FYN phosphorylate FCER1G in CLEC6A:FCERG and CLEC4E:FCERG" xref: Reactome:R-HSA-5621363 "SYK phosphorylates PLCG2 in p-6Y-SYK:p-Y65,Y76-FCER1G:PLCG2" xref: Reactome:R-HSA-5621370 "SYK autophosphorylates" xref: Reactome:R-HSA-5624486 "SFKs phosphorylates RAF1 on Y340,Y341" xref: Reactome:R-HSA-5637795 "Phosphorylation of PLC-gamma 1 by p-EGFRvIII mutant" xref: Reactome:R-HSA-5637796 "Phosphorylation of SHC1 by p-5Y-EGFRvIII" xref: Reactome:R-HSA-5654147 "Activated FGFR2 phosphorylates PLCG1" xref: Reactome:R-HSA-5654149 "Activated FGFR1 phosphorylates PLCG1" xref: Reactome:R-HSA-5654151 "Activated FGFR4 phosphorylates PLCG1" xref: Reactome:R-HSA-5654222 "Activated FGFR3 phosphorylates PLCG1" xref: Reactome:R-HSA-5654397 "Activated FGFR2 phosphorylates FRS2" xref: Reactome:R-HSA-5654407 "Activated FGFR2 phosphorylates SHC1" xref: Reactome:R-HSA-5654408 "Activated FGFR3 phosphorylates FRS2" xref: Reactome:R-HSA-5654418 "Activated FGFR4 phosphorylates FRS2" xref: Reactome:R-HSA-5654428 "Activated FGFR4 phosphorylates SHC1" xref: Reactome:R-HSA-5654545 "Ligand-independent phosphorylation of overexpressed FGFR1c" xref: Reactome:R-HSA-5654575 "Activated FGFR1 phosphorylates FRS2" xref: Reactome:R-HSA-5654578 "Activated FGFR1 phosphorylates FRS3" xref: Reactome:R-HSA-5654582 "Activated FGFR1 phosphorylates SHC1" xref: Reactome:R-HSA-5654587 "Activated FGFR1:p-FRS phosphorylates PPTN11" xref: Reactome:R-HSA-5654605 "Activated FGFR2 phosphorylates FRS3" xref: Reactome:R-HSA-5654607 "Activated FGFR2 phosphorylates PPTN11" xref: Reactome:R-HSA-5654628 "Activated FGFR3 phosphorylates FRS3" xref: Reactome:R-HSA-5654631 "Activated FGFR3 phosphorylates PPTN11" xref: Reactome:R-HSA-5654634 "Activated FGFR3 phosphorylates SHC1" xref: Reactome:R-HSA-5654653 "Activated FGFR4 phosphorylates FRS3" xref: Reactome:R-HSA-5654655 "Activated FGFR4 phosphorylates PPTN11" xref: Reactome:R-HSA-5655243 "Activated FGFR3 point and translocation mutants phosphorylate PLCG1" xref: Reactome:R-HSA-5655268 "Activated FGFR2 mutants phosphorylate FRS2" xref: Reactome:R-HSA-5655270 "Activated FGFR3 point, translocation and fusion mutants phosphorylate FRS2" xref: Reactome:R-HSA-5655278 "Activated FGFR1 mutants phosphorylate FRS2" xref: Reactome:R-HSA-5655284 "Activated FGFR4 mutants phosphorylate FRS2" xref: Reactome:R-HSA-5655301 "Activated FGFR2 mutants phosphorylate PLCG1" xref: Reactome:R-HSA-5655341 "Activated FGFR4 mutants phosphorylate PLCG1" xref: Reactome:R-HSA-5683930 "WICH phosphorylates H2AFX on Y142" xref: Reactome:R-HSA-5686587 "ABL1 phosphorylates RAD52" xref: Reactome:R-HSA-5690702 "LYN phosphorylates CD22" xref: Reactome:R-HSA-6784006 "STAT3 is phosphorylated by p-Y-JAK1,P-Y-TYK2" xref: Reactome:R-HSA-6784319 "JAK1,TYK2 phosphorylate JAK1,TYK2" xref: Reactome:R-HSA-6790087 "HVEM induses BTLA phosphorylation" xref: Reactome:R-HSA-6806974 "MET dimers autophosphorylate" xref: Reactome:R-HSA-68954 "Mcm2-7 is phosphorylated by DDK" xref: Reactome:R-HSA-69195 "Phosphorylation of Cyclin E:CDK2 complexes by WEE1" xref: Reactome:R-HSA-873918 "Transphosphorylation of JAK1" xref: Reactome:R-HSA-873919 "Phosphorylation of JAK2" xref: Reactome:R-HSA-873922 "Phosphorylation of STAT1 by JAK kinases" xref: Reactome:R-HSA-873924 "Phosphorylation of IFNGR1 by JAK kinases" xref: Reactome:R-HSA-879907 "Tyrosine kinases phosphorylate the receptor" xref: Reactome:R-HSA-879909 "Activation of STAT5a/b by JAK2" xref: Reactome:R-HSA-879925 "SHC1 bound to the common beta chain becomes tyrosine phosphorylated" xref: Reactome:R-HSA-8847977 "FRK phosphorylates PTEN" xref: Reactome:R-HSA-8848005 "ERBB2 promotes PTK6 autophosphorylation" xref: Reactome:R-HSA-8848077 "PTK6 phosphorylates STAP2" xref: Reactome:R-HSA-8848124 "PTK6 phosphorylates STAT3" xref: Reactome:R-HSA-8848436 "PTK6 phosphorylates CDKN1B" xref: Reactome:R-HSA-8848606 "PTK6 phosphorylates PXN" xref: Reactome:R-HSA-8848726 "PTK6 phosphorylates BCAR1" xref: Reactome:R-HSA-8848758 "PTK6 phosphorylates AKT1" xref: Reactome:R-HSA-8848776 "PTK6 phosphorylates DOK1" xref: Reactome:R-HSA-8848818 "PTK6 phosphorylates CBL" xref: Reactome:R-HSA-8848873 "PTK6 phosphorylates ARAP1" xref: Reactome:R-HSA-8848975 "PTK6 phosphorylates KHDRBS1" xref: Reactome:R-HSA-8849032 "PTK6 phosphorylates KHDRBS2" xref: Reactome:R-HSA-8849042 "PTK6 phosphorylates KHDRBS3" xref: Reactome:R-HSA-8849068 "PTK6 phosphorylates ARHGAP35" xref: Reactome:R-HSA-8849102 "SRMS phosphorylates PTK6" xref: Reactome:R-HSA-8849463 "PTK6 phosphorylates SFPQ" xref: Reactome:R-HSA-8851890 "MET phosphorylates SHC1-2" xref: Reactome:R-HSA-8851933 "MET phosphorylates GAB1" xref: Reactome:R-HSA-8853309 "Autocatalytic phosphorylation of FGFR3 fusions" xref: Reactome:R-HSA-8853313 "FGFR2 fusions autophosphorylate" xref: Reactome:R-HSA-8853325 "Plasma membrane FGFR1 fusions autophosphorylate" xref: Reactome:R-HSA-8855237 "FYN phosphorylates DAB1 in RELN:VLDLR:DAB1:SH3KBP1" xref: Reactome:R-HSA-8857555 "EGFR phosphorylates GPNMB" xref: Reactome:R-HSA-8857577 "LINC01139 facilitates PTK6 autophosphorylation" xref: Reactome:R-HSA-8857583 "LINC01139 promotes phosphorylation of HIF1A by PTK6" xref: Reactome:R-HSA-8857925 "Inhibition of PP2A activity by phosphorylation of the catalytic subunit at tyrosine Y307" xref: Reactome:R-HSA-8867041 "EGFR phosphorylates EPS15" xref: Reactome:R-HSA-8874078 "PTK2 autophosphorylates" xref: Reactome:R-HSA-8874080 "SRC phosphorylates PTK2" xref: Reactome:R-HSA-8874082 "MET phosphorylates PTK2" xref: Reactome:R-HSA-8875451 "MET phosphorylates CBL" xref: Reactome:R-HSA-8875817 "MET phosphorylates STAT3" xref: Reactome:R-HSA-8876230 "InlB:MET dimer trans-autophophorylates" xref: Reactome:R-HSA-8876246 "InlB-activated MET phosphorylates CBL" xref: Reactome:R-HSA-8876948 "SRC phosphorylates InlA-bound CDH1 and CTNNB1" xref: Reactome:R-HSA-8937728 "SRC phosphorylates RUNX1" xref: Reactome:R-HSA-8937807 "SRC phosphorylates RUNX3" xref: Reactome:R-HSA-8937844 "SRC,YES1 phosphorylate YAP1" xref: Reactome:R-HSA-8942607 "Tyrosine kinases phosphorylate Cip/Kip inhibitors bound to CDK4/6:CCND complexes" xref: Reactome:R-HSA-8948143 "p-S13, FUNDC1 is phosphorylated by CK2 at Tyr18" xref: Reactome:R-HSA-8956659 "ABL1 phosphorylates YAP1" xref: Reactome:R-HSA-8964242 "G protein alpha (i)-SRC complex catalyzes SRC to p-Y419-SRC" xref: Reactome:R-HSA-8964252 "G alpha (s):GTP:SRC catalyzes SRC to p-Y419-SRC" xref: Reactome:R-HSA-8983872 "JAK2 bound to IL12RB2:IL12RB2 phosphorylate STAT4" xref: Reactome:R-HSA-9006323 "Phospho-JAK2 phosphorylates EPOR" xref: Reactome:R-HSA-9006332 "JAK2 transphosphorylates and is activated in response to Erythropoietin" xref: Reactome:R-HSA-9011241 "SRC phosphorylates ROBO3.1 in response to NTN1" xref: Reactome:R-HSA-9012650 "JAK2 and LYN phosphorylate STAT5 in EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2" xref: Reactome:R-HSA-9018572 "EGFR phosphorylates NOTCH3" xref: Reactome:R-HSA-9021609 "ESR-associated SRC autophosphorylates" xref: Reactome:R-HSA-9024726 "LYN phosphorylates CRKL in EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:CRKL:RAPGEF1" xref: Reactome:R-HSA-9026464 "BDNF-bound NTRK2 dimers trans-autophosphorylate" xref: Reactome:R-HSA-9026502 "NTF3-bound NTRK2 dimers trans-autophosphorylate" xref: Reactome:R-HSA-9026510 "NTF4-bound NTRK2 dimers trans-autophosphorylate" xref: Reactome:R-HSA-9026579 "NTRK2 phosphorylates PLCG1" xref: Reactome:R-HSA-9026890 "NTRK2 phosphorylates SHC1" xref: Reactome:R-HSA-9027272 "EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 phosphorylates IRS2" xref: Reactome:R-HSA-9027273 "JAK2 phosphorylates GAB1 in EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:GAB1" xref: Reactome:R-HSA-9027425 "LYN phosphorylates PLCG1,2 in EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:PLCG1,2" xref: Reactome:R-HSA-9028728 "NTRK2 phosphorylates FRS2" xref: Reactome:R-HSA-9029151 "JAK2 phosphorylates VAV1 in EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-Y-CRKL:RASGEF1:p-Y-SHC1:GRB2:VAV1" xref: Reactome:R-HSA-9029155 "JAK2 phosphorylates SHC1 in EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:p-CRKL:RABGEF1:SHC1" xref: Reactome:R-HSA-9032426 "NTRK2 phosphorylates FRS3" xref: Reactome:R-HSA-9032532 "NTRK2-bound FYN autophosphorylates" xref: Reactome:R-HSA-9032601 "FYN-mediated phosphorylation of GRIN2B" xref: Reactome:R-HSA-9032854 "NTRK2 phosphorylates CDK5" xref: Reactome:R-HSA-9033284 "NTRK2 promotes TIAM1 phosphorylation" xref: Reactome:R-HSA-9034714 "NTRK3 dimers trans-autophosphorylate" xref: Reactome:R-HSA-9034814 "NTRK3 phosphorylates PLCG1" xref: Reactome:R-HSA-9034875 "NTRK3 phosphorylates SHC1" xref: Reactome:R-HSA-9037040 "SRC,FYN phosphorylate NTRK2" xref: Reactome:R-HSA-909718 "Formation of p-STAT1 homodimer" xref: Reactome:R-HSA-909726 "Phosphorylation of STAT1" xref: Reactome:R-HSA-909729 "Activation of JAK kinases" xref: Reactome:R-HSA-909730 "Phosphorylation of INFAR1 by TYK2" xref: Reactome:R-HSA-909732 "Phosphorylation of STAT2" xref: Reactome:R-HSA-912629 "CBL is tyrosine phosphorylated" xref: Reactome:R-HSA-9603420 "Activated NTRK3 promotes SRC autophosphorylation" xref: Reactome:R-HSA-9604767 "FLT3LG dimer:FLT3 dimer autophosphorylates" xref: Reactome:R-HSA-9606159 "BTK autophosphorylates" xref: Reactome:R-HSA-9606162 "Phosphorylated BTK phosphorylates PLCG2" xref: Reactome:R-HSA-9606163 "p-SYK and LYN phosphorylate BTK" xref: Reactome:R-HSA-9612085 "SRC phosphorylates GluN2 (GRIN2) subunits of NMDARs" xref: Reactome:R-HSA-9612996 "NTRK1,2 in ADCYAP1(2-742):ADCYAP1R1:NTRK1,2 autophosphorylates" xref: Reactome:R-HSA-9613023 "NTRK1,2 in Ade-Rib:ADORA2A:NTRK1,2 autophosphorylates" xref: Reactome:R-HSA-9624014 "SHC1 is phosphorylated downstream of estrogen stimulation of GPER1" xref: Reactome:R-HSA-9625487 "PTK2 autophosphorylates downstream of EGFR" xref: Reactome:R-HSA-9634390 "ERBB2 homodimer phosphorylates SHC1" xref: Reactome:R-HSA-9664261 "Src phosphorylate SYK in IgG:Leishmania surface:p-FCGR3A:SYK" xref: Reactome:R-HSA-9664275 "Src phosphorylates CD3 dimers in IgG:Lma antigens:FCGR3A:CD3 dimers" xref: Reactome:R-HSA-9664278 "Phosphorylation and activation of PLCG due to FCGR3A effect" xref: Reactome:R-HSA-9664588 "ERBB2 KD mutants trans-autophosphorylate" xref: Reactome:R-HSA-9664976 "Phosphorylated heterodimers of ERBB2 KD mutants phosphorylate SHC1" xref: Reactome:R-HSA-9665032 "Phosphorylated heterodimers of ERBB2 KD mutants and EGFR phosphorylate PLCG1" xref: Reactome:R-HSA-9665389 "Heterodimers of ERBB2 ECD mutants and EGFR trans-autophosphorylate" xref: Reactome:R-HSA-9665411 "Phosphorylated heterodimers of ERBB2 ECD mutants and EGFR phosphorylate PLCG1" xref: Reactome:R-HSA-9665704 "Phosphorylated heterodimers of ERBB2 TMD/JMD mutants and EGFR phosphorylate PLCG1" xref: Reactome:R-HSA-9665705 "Phosphorylated heterodimers of ERBB2 TMD/JMD mutants phosphorylate SHC1" xref: Reactome:R-HSA-9665709 "ERBB2 TMD/JMD heterodimers trans-autophosphorylate" xref: Reactome:R-HSA-9666425 "p-6Y-SYK phosphorylates VAV1,2,3" xref: Reactome:R-HSA-9669890 "Constitutive phosphorylation of kinase domain KIT mutants" xref: Reactome:R-HSA-9669911 "Phosphorylation of juxtamembrane domain KIT mutants" xref: Reactome:R-HSA-9670412 "Phosphorylation of STATs downstream of KIT mutants" xref: Reactome:R-HSA-9670418 "Phosphorylation of JAK2 downstream of KIT mutants" xref: Reactome:R-HSA-9672173 "Autophosphorylation of PDGFRA extracellular domain dimers" xref: Reactome:R-HSA-9672175 "Autophosphorylation of PDGFR mutant dimers" xref: Reactome:R-HSA-9673756 "Autophosphorylation of cytosolic PDGFRA and PDGFRB fusion proteins" xref: Reactome:R-HSA-9673761 "Autophosphorylation of membrane-tethered fusions of PDGFRA or PDGFRB" xref: Reactome:R-HSA-9674558 "p-Y-JAK1 phosphorylates CSF3R in CSF3 dimer:2xCSF3R:LYN:p-Y-JAK1" xref: Reactome:R-HSA-9674567 "p-Y-JAK1,2 phosphorylates STAT1,3,5 in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-Y-JAK2:p-TYK2" xref: Reactome:R-HSA-9680248 "Phosphorylation of extracellular domain KIT mutants" xref: Reactome:R-HSA-9695834 "Constitutive phosphorylation of FLT3 mutants" xref: Reactome:R-HSA-9698003 "FLT3 mutants phosphorylate GAB2" xref: Reactome:R-HSA-9698005 "FLT3 ITD mutants phosphorylate STAT5" xref: Reactome:R-HSA-9699578 "Active FLT3 phosphorylates CDKN1B" xref: Reactome:R-HSA-9700164 "Active ALK phosphorylates FRS2" xref: Reactome:R-HSA-9700168 "Active ALK phosphorylates IRS1" xref: Reactome:R-HSA-9700171 "Active ALK phosphorylates PLCG1" xref: Reactome:R-HSA-9700175 "Active ALK phosphorylates SHC1" xref: Reactome:R-HSA-9700181 "Autophosphorylation of ALK fusions" xref: Reactome:R-HSA-9700186 "Autophosphorylation of point mutants of ALK" xref: Reactome:R-HSA-9700193 "ALK mutants phosphorylate SHC1" xref: Reactome:R-HSA-9700647 "Active ALK phosphorylates SRC" xref: Reactome:R-HSA-9701488 "Active ALK phosphorylates JAK3" xref: Reactome:R-HSA-9703437 "FLT3 fusion dimers autophosphorylate" xref: Reactome:R-HSA-9703438 "FLT3 fusions phosphorylate GAB2" xref: Reactome:R-HSA-9706344 "FLT3 phosphorylates GRB10" xref: Reactome:R-HSA-9706350 "FLT3 phosphorylates CBL" xref: Reactome:R-HSA-9709918 "PTK6 phosphorylates STAT3" xref: Reactome:R-HSA-9712082 "ALK fusions phosphorylate IRS1" xref: Reactome:R-HSA-9712085 "ALK mutants phosphorylate STAT3" xref: Reactome:R-HSA-9712086 "ALK fusions phosphorylate PLCG1" xref: Reactome:R-HSA-9712087 "ALK fusions phosphorylate FRS" xref: Reactome:R-HSA-9726848 "SRC phosphorylates RHOU" xref: Reactome:R-HSA-9732738 "JAK1-mediated phosphorylation of RAF1" xref: Reactome:R-HSA-9733314 "CSF1R trans-autophosphorylates on tyrosine-561" xref: Reactome:R-HSA-9733323 "Src family kinases phosphorylate CBL in CSF1 dimer:p-Y561-CSF1R dimer:CBL" xref: Reactome:R-HSA-9762209 "BACH1 is phosphorylated at tyrosine 483" xref: Reactome:R-HSA-982807 "JAK2 phosphorylation of GHR" xref: Reactome:R-HSA-9831136 "SH pentamer is phosphorylated" xref: Reactome:R-HSA-983703 "p-6Y-SYK phosphorylates BLNK (SLP65)" xref: Reactome:R-HSA-983707 "SYK autophosphorylates at the activated BCR" xref: Reactome:R-HSA-983709 "LYN, FYN, BLK phosphorylate ITAMs of Ig-alpha (CD79A) and Ig-beta (CD79B)" xref: Reactome:R-HSA-9841924 "ABL1 phosphorylates PPARG2" xref: Reactome:R-HSA-9842648 "Autophosphorylation of LTK dimer:ALKAL1,2" xref: Reactome:R-HSA-9842651 "Active LTK receptor phosphorylates SHC1" xref: Reactome:R-HSA-9842666 "Active LTK phosphorylates IRS1" xref: Reactome:R-HSA-9842667 "CLIP1-LTK fusion autophosphorylates" xref: Reactome:R-HSA-9860500 "Phosphorylation of KDR (VEGFR2) and FLT4 (VEGFR3) and PECAM1 in PECAM1:CDH5:KDR:FLT4:CTNNB1" xref: Reactome:R-HSA-9860759 "p-T816-PKN2 phosphorylates AKT1 on serine-308" xref: Reactome:R-HSA-9861469 "p-Y397-PTK2 (FAK) phosphorylates CHUK (IKKA)" xref: Reactome:R-HSA-9865196 "p-Y393-ABL1 phosphorylates tyrosine-407 of YAP1" xref: Reactome:R-HSA-9931290 "IL6-activated JAK1 phosphorylates CD274" xref: Reactome:R-HSA-9934751 "CDH1 is phosphorylated on tyrosine residues" xref: RHEA:10596 {source="skos:exactMatch"} is_a: GO:0004672 ! protein kinase activity relationship: has_participant CHEBI:15378 relationship: has_participant CHEBI:30616 relationship: has_participant CHEBI:456216 relationship: has_participant CHEBI:46858 relationship: has_participant CHEBI:61978 [Term] id: GO:0004714 name: transmembrane receptor protein tyrosine kinase activity namespace: molecular_function def: "Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate." [EC:2.7.10.1, GOC:mah] synonym: "receptor protein tyrosine kinase activity" RELATED [EC:2.7.10.1] synonym: "receptor protein-tyrosine kinase activity" RELATED [EC:2.7.10.1] xref: EC:2.7.10.1 {source="skos:exactMatch"} xref: Reactome:R-HSA-166544 "TrkA receptor autophosphorylates" xref: Reactome:R-HSA-167019 "SHC, complexed with TrkA, is tyrosine-phosphorylated" xref: Reactome:R-HSA-167683 "TrkA phosphorylates PLCG1" xref: Reactome:R-HSA-169905 "ARMS is phosphorylated by active TrkA receptor" xref: Reactome:R-HSA-177930 "GAB1 phosphorylation by EGFR kinase" xref: Reactome:R-HSA-177933 "SHC1 phosphorylation by phosphorylated EGFR" xref: Reactome:R-HSA-198295 "TRKA phosphorylates IRS" xref: Reactome:R-HSA-6784324 "p-Y-JAK1,p-Y-TYK2 phosphorylate IL10RA" xref: Reactome:R-HSA-74711 "Phosphorylation of IRS" xref: Reactome:R-HSA-74742 "Phosphorylation of SHC1" xref: Reactome:R-HSA-8852552 "MST1R autophosphorylates" xref: Reactome:R-HSA-8853792 "RET tyrosine phosphorylation" xref: Reactome:R-HSA-8950269 "STAT3, STAT4 are phosphorylated by p-JAK2, p-TYK2 in IL23:IL23 receptor" xref: Reactome:R-HSA-8950340 "IL27RA and IL6ST are phosphorylated after IL27:IL27 receptor interaction and JAK's phosphorylation" xref: Reactome:R-HSA-8950354 "STAT4 is phosphorylated by p-JAK2 and/or p-Y-TYK2 after IL12:IL12R interaction" xref: Reactome:R-HSA-8950364 "IL23R in IL23:IL23 receptor complex is phosphorylated" xref: Reactome:R-HSA-8950405 "JAK1/JAK2 bound to IL35:IL6ST:IL12RB2 receptor are phosphorylated" xref: Reactome:R-HSA-8950423 "JAK2, TYK2 in IL12A:IL12RB1:TYK2:IL12B:IL12RB2:JAK2 are phosphorylated" xref: Reactome:R-HSA-8950453 "JAK1/JAK2 bound to IL12RB2:IL6ST receptor phosphorylates STAT1 and STAT4" xref: Reactome:R-HSA-8950485 "STAT3 and STAT1 are phosphorylated by JAKs after IL27:IL27R interaction" xref: Reactome:R-HSA-8950537 "JAK1, JAK2, TYK2 in IL27:EBI3:IL27RA:JAK1:IL6ST:(JAK1,JAK2,TYK2) are phosphorylated" xref: Reactome:R-HSA-8950591 "JAK2, TYK2 in IL23A:IL12B:IL23R:JAK2:IL12RB1:TYK2 are phosphorylated" xref: Reactome:R-HSA-8950757 "IL12RB2 in IL12A:IL12RB1:p-Y-TYK2:IL12B:IL12RB2:p-JAK2 is phosphorylated" xref: Reactome:R-HSA-8982163 "IL19:IL20RA:p-JAK1:IL20RB:STAT3 phosphorylates STAT3" xref: Reactome:R-HSA-8983300 "IL15RA:IL15:IL2RB:JAK1:IL2RG:JAK3 phosphorylates JAK3 and JAK1" xref: Reactome:R-HSA-8983309 "IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 phosphorylates SHC1" xref: Reactome:R-HSA-8983371 "IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 phosphorylates STAT3 and STAT5" xref: Reactome:R-HSA-8983424 "IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2:GAB2 phosphorylates GAB2" xref: Reactome:R-HSA-8986985 "IFNL1:p-Y343,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2:STAT1 phosphorylates STAT1, STAT2, STAT3, STAT4 and STAT5" xref: Reactome:R-HSA-8986994 "IL26:IL20RA:JAK1:IL10RB:TYK2 phosphorylates JAK1, TYK2" xref: Reactome:R-HSA-8986995 "IL22:IL22RA1:p-JAK1:IL10RB:p-TYK2 phosphorylates IL22RA" xref: Reactome:R-HSA-8987012 "IL24:IL22RA1:JAK1:IL20RB phosphorylates JAK1" xref: Reactome:R-HSA-8987040 "IFNL1:IFNLR1:p-JAK1:IL10RB:p-TYK2 phosphorylates IFNLR1" xref: Reactome:R-HSA-8987042 "IL22:IL22RA1:JAK1:IL10RB:TYK2 phosphorylates JAK1,TYK2" xref: Reactome:R-HSA-8987070 "IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2:STAT3 phosphorylates STAT3" xref: Reactome:R-HSA-8987084 "IL19:IL20RA:JAK1:IL20RB phosphorylates JAK1" xref: Reactome:R-HSA-8987096 "IL24:IL22RA1:p-JAK1:IL20RB:STAT3 phosphorylates STAT3" xref: Reactome:R-HSA-8987129 "JAK1 in IL24:IL20RA:JAK1:IL20RB is phosphorylated" xref: Reactome:R-HSA-8987141 "IL20:IL20RA:JAK1:IL20RB:p-JAK3,p-JAK2:STAT3 phosphorylates STAT3" xref: Reactome:R-HSA-8987150 "IL24:IL20RA:p-JAK1:IL20RB:STAT1,STAT3 phosphorylates STAT1 or STAT3" xref: Reactome:R-HSA-8987179 "IL20:IL20RA:JAK1:IL20RB:JAK2,JAK3 phosphorylates JAK2,JAK3" xref: Reactome:R-HSA-8987202 "IFNL1:IFNLR1:JAK1:IL10RB:TYK2 phosphorylates JAK1,TYK2" xref: Reactome:R-HSA-8987255 "IL26:IL10RB:p-TYK2:IL20RA:p-JAK1:STAT1,STAT3 phosphorylates STAT1,STAT3" is_a: GO:0004713 ! protein tyrosine kinase activity is_a: GO:0019199 ! transmembrane receptor protein kinase activity property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/28176" xsd:anyURI [Term] id: GO:0004888 name: transmembrane signaling receptor activity namespace: molecular_function def: "Combining with an extracellular or intracellular signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity or state as part of signal transduction." [GOC:go_curators, Wikipedia:Transmembrane_receptor] comment: This term includes intracellular membrane receptors, e.g. IP3 triggered release of Ca2+ from intracellular stores. synonym: "transmembrane receptor activity" BROAD [GOC:bf, GOC:signaling] synonym: "transmembrane signalling receptor activity" EXACT [GOC:mah] xref: Reactome:R-HSA-193672 "Sphingomyelinase is activated by the NGF:p75NTR complex" is_a: GO:0038023 ! signaling receptor activity [Term] id: GO:0004896 name: cytokine receptor activity namespace: molecular_function def: "Combining with a cytokine and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:add, GOC:mah] synonym: "hematopoietin/interferon-class (D200-domain) cytokine receptor activity" RELATED [] synonym: "IL receptor" NARROW [] synonym: "interleukin receptor activity" NARROW [http://wiki.geneontology.org/index.php/Why_isn%27t_interleukin_in_GO%3F] is_a: BFO:0000003 is_a: GO:0004888 ! transmembrane signaling receptor activity is_a: GO:0140375 ! immune receptor activity relationship: BFO:0000050 GO:0019221 ! part of cytokine-mediated signaling pathway relationship: BFO:0000051 GO:0019955 ! has part cytokine binding property_value: RO:0002161 NCBITaxon:4751 [Term] id: GO:0004925 name: prolactin receptor activity namespace: molecular_function def: "Combining with prolactin and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:mah, GOC:signaling] is_a: GO:0004896 ! cytokine receptor activity intersection_of: GO:0038023 ! signaling receptor activity intersection_of: RO:0004009 PR:000013246 ! has primary input prolactin relationship: BFO:0000050 GO:0038161 ! part of prolactin signaling pathway relationship: RO:0004009 PR:000013246 ! has primary input prolactin property_value: RO:0002161 NCBITaxon:4751 [Term] id: GO:0004930 name: G protein-coupled receptor activity namespace: molecular_function def: "Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, Wikipedia:GPCR] subset: goslim_chembl synonym: "EBV-induced receptor" NARROW [] synonym: "Epstein-Barr Virus-induced receptor activity" NARROW [] synonym: "G protein coupled receptor activity" EXACT [] synonym: "G protein linked receptor activity" EXACT [] synonym: "G-protein coupled receptor activity" EXACT [] synonym: "G-protein coupled receptor activity, unknown ligand" NARROW [] synonym: "G-protein linked receptor activity" EXACT [] synonym: "GPCR activity" EXACT [] synonym: "ligand-dependent GPCR activity" EXACT [] synonym: "Mas proto-oncogene receptor activity" NARROW [] synonym: "orphan G protein coupled receptor activity" NARROW [] synonym: "orphan G-protein coupled receptor activity" NARROW [] synonym: "orphan GPCR activity" NARROW [] synonym: "RDC1 receptor activity" NARROW [] synonym: "receptor activity, G-protein coupled" EXACT [GOC:bf] synonym: "SREB receptor" NARROW [] synonym: "super conserved receptor expressed in brain receptor activity" NARROW [] xref: Reactome:R-HSA-114552 "Thrombin-activated PARs activate G12/13" xref: Reactome:R-HSA-114558 "Thrombin-activated PARs activate Gq" xref: Reactome:R-HSA-167408 "The high affinity receptor complex binds to G-protein" xref: Reactome:R-HSA-381706 "GLP1R:GLP1 activates G(s)" xref: Wikipedia:GPCR is_a: BFO:0000003 is_a: GO:0004888 ! transmembrane signaling receptor activity relationship: BFO:0000050 GO:0007186 ! part of G protein-coupled receptor signaling pathway [Term] id: GO:0004948 name: calcitonin receptor activity namespace: molecular_function def: "Combining with calcitonin and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:mah, GOC:signaling, PMID:21649645] is_a: GO:0097642 ! calcitonin family receptor activity intersection_of: GO:0038023 ! signaling receptor activity intersection_of: RO:0004009 CHEBI:3306 ! has primary input relationship: BFO:0000051 GO:0032841 ! has part calcitonin binding relationship: RO:0004009 CHEBI:3306 ! has primary input [Term] id: GO:0004951 name: cholecystokinin receptor activity namespace: molecular_function def: "Combining with cholecystokinin and transmitting the signal across the membrane by activating an associated G-protein to initiate a change in cell activity. Cholecystokinin can act as a neuropeptide or as a gastrointestinal hormone." [GOC:signaling, PMID:9835394] synonym: "CCK receptor activity" EXACT [PR:000005110, Wikipedia:Cholecystokinin] is_a: GO:0008528 ! G protein-coupled peptide receptor activity intersection_of: GO:0038023 ! signaling receptor activity intersection_of: RO:0004009 PR:000005110 ! has primary input cholecystokinin relationship: BFO:0000050 GO:0038188 ! part of cholecystokinin signaling pathway relationship: RO:0004009 PR:000005110 ! has primary input cholecystokinin [Term] id: GO:0004966 name: galanin receptor activity namespace: molecular_function def: "Combining with galanin to initiate a change in cell activity." [GOC:ai] is_a: GO:0008188 ! neuropeptide receptor activity intersection_of: GO:0038023 ! signaling receptor activity intersection_of: RO:0004009 PR:000007806 ! has primary input galanin relationship: RO:0004009 PR:000007806 ! has primary input galanin property_value: RO:0002161 NCBITaxon:4751 [Term] id: GO:0004967 name: glucagon receptor activity namespace: molecular_function def: "Combining with glucagon and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:mah, GOC:signaling, PMID:22438981] xref: Reactome:R-HSA-163625 "Glucagon binds to Glucagon receptor" is_a: GO:0008528 ! G protein-coupled peptide receptor activity intersection_of: GO:0038023 ! signaling receptor activity intersection_of: RO:0004009 CHEBI:5391 ! has primary input relationship: BFO:0000050 GO:0071377 ! part of cellular response to glucagon stimulus relationship: RO:0004009 CHEBI:5391 ! has primary input property_value: RO:0002161 NCBITaxon:4751 [Term] id: GO:0004969 name: histamine receptor activity namespace: molecular_function def: "Combining with histamine to initiate a change in cell activity. Histamine is a physiologically active amine, found in plant and animal tissue and released from mast cells as part of an allergic reaction in humans." [GOC:ai] is_a: GO:0008227 ! G protein-coupled amine receptor activity intersection_of: GO:0038023 ! signaling receptor activity intersection_of: RO:0004009 CHEBI:58432 ! has primary input relationship: BFO:0000051 GO:0051381 ! has part histamine binding relationship: RO:0004009 CHEBI:58432 ! has primary input [Term] id: GO:0004970 name: glutamate-gated receptor activity namespace: molecular_function def: "Catalysis of the transmembrane transfer of an ion by a channel that opens when glutamate has been bound by the channel complex or one of its constituent parts." [ISBN:0198506732] comment: Note that this term represents an activity and not a gene product. Consider also annotating to the molecular function terms 'glutamate-gated ion channel activity ; GO:0005234' and 'cation channel activity ; GO:0005261'. synonym: "ionotropic glutamate receptor activity" EXACT [] is_a: GO:0008066 ! glutamate receptor activity is_a: GO:0015171 ! amino acid transmembrane transporter activity is_a: GO:0022824 ! transmitter-gated monoatomic ion channel activity is_a: GO:0046943 ! carboxylic acid transmembrane transporter activity intersection_of: GO:0022836 ! gated channel activity intersection_of: RO:0004009 CHEBI:24867 ! has primary input intersection_of: RO:0012001 CHEBI:14321 ! has small molecule activator relationship: BFO:0000050 GO:0035235 ! part of ionotropic glutamate receptor signaling pathway relationship: RO:0012001 CHEBI:14321 ! has small molecule activator [Term] id: GO:0004977 name: melanocortin receptor activity namespace: molecular_function def: "Combining with melanocortin to initiate a change in cell activity." [GOC:ai] is_a: GO:0008528 ! G protein-coupled peptide receptor activity [Term] id: GO:0004978 name: corticotropin receptor activity namespace: molecular_function def: "Combining with corticotropin to initiate a change in cell activity." [GOC:ai] synonym: "ACTH receptor activity" EXACT [] synonym: "adrenocorticotropic hormone receptor activity" EXACT [] synonym: "adrenocorticotropin receptor activity" EXACT [] is_a: GO:0004977 ! melanocortin receptor activity is_a: GO:0008188 ! neuropeptide receptor activity intersection_of: GO:0038023 ! signaling receptor activity intersection_of: RO:0004009 CHEBI:3892 ! has primary input relationship: BFO:0000051 GO:0042562 ! has part hormone binding relationship: RO:0004009 CHEBI:3892 ! has primary input property_value: RO:0002161 NCBITaxon:4751 [Term] id: GO:0004983 name: neuropeptide Y receptor activity namespace: molecular_function def: "Combining with neuropeptide Y to initiate a change in cell activity." [PMID:9315606] is_a: GO:0008188 ! neuropeptide receptor activity intersection_of: GO:0038023 ! signaling receptor activity intersection_of: RO:0004009 PR:000011387 ! has primary input neuropeptide Y relationship: RO:0004009 PR:000011387 ! has primary input neuropeptide Y property_value: RO:0002161 NCBITaxon:4751 [Term] id: GO:0004990 name: oxytocin receptor activity namespace: molecular_function def: "Combining with oxytocin to initiate a change in cell activity." [GOC:ai] is_a: GO:0008528 ! G protein-coupled peptide receptor activity intersection_of: GO:0038023 ! signaling receptor activity intersection_of: RO:0004009 CHEBI:7872 ! has primary input relationship: RO:0004009 CHEBI:7872 ! has primary input [Term] id: GO:0004993 name: G protein-coupled serotonin receptor activity namespace: molecular_function def: "Combining with the biogenic amine serotonin and transmitting the signal across the membrane by activating an associated G-protein. Serotonin (5-hydroxytryptamine) is a neurotransmitter and hormone found in vertebrates and invertebrates." [GOC:ai] synonym: "5-HT receptor" EXACT [] synonym: "5-hydroxytryptamine receptor" EXACT [] synonym: "G protein coupled serotonin receptor activity" EXACT [] synonym: "G-protein coupled serotonin receptor activity" EXACT [] xref: Wikipedia:5-HT_receptor is_a: GO:0008227 ! G protein-coupled amine receptor activity intersection_of: GO:0008227 ! G protein-coupled amine receptor activity intersection_of: RO:0004009 CHEBI:350546 ! has primary input relationship: BFO:0000050 GO:0098664 ! part of G protein-coupled serotonin receptor signaling pathway relationship: BFO:0000051 GO:0051378 ! has part serotonin binding relationship: RO:0004009 CHEBI:350546 ! has primary input property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/12942" xsd:anyURI [Term] id: GO:0004994 name: somatostatin receptor activity namespace: molecular_function def: "Combining with somatostatin to initiate a change in cell activity. Somatostatin is a peptide hormone that regulates the endocrine system by signaling via G protein-coupled somatostatin receptors. Somatostatin has two active forms produced by proteolytic cleavage: a 14 amino acid peptide (SST-14) and a 28 amino acid peptide (SST-28)." [GOC:ai, GOC:bf, Wikipedia:Somatostatin] synonym: "GHIH receptor activity" EXACT [Wikipedia:Somatostatin] synonym: "growth hormone-inhibiting hormone receptor activity" EXACT [Wikipedia:Somatostatin] synonym: "somatotrophin release inhibiting factor receptor activity" EXACT [Wikipedia:Somatostatin] synonym: "SRIF receptor activity" EXACT [Wikipedia:Somatostatin] synonym: "SST receptor activity" EXACT [Wikipedia:Somatostatin] is_a: GO:0008188 ! neuropeptide receptor activity intersection_of: GO:0038023 ! signaling receptor activity intersection_of: RO:0004009 CHEBI:64628 ! has primary input relationship: BFO:0000050 GO:0038170 ! part of somatostatin signaling pathway relationship: RO:0004009 CHEBI:64628 ! has primary input property_value: RO:0002161 NCBITaxon:4751 [Term] id: GO:0005000 name: vasopressin receptor activity namespace: molecular_function def: "Combining with vasopressin to initiate a change in cell activity." [GOC:ai] synonym: "vasopressin activated calcium mobilizing receptor activity" NARROW [] is_a: GO:0008528 ! G protein-coupled peptide receptor activity intersection_of: GO:0038023 ! signaling receptor activity intersection_of: RO:0004009 CHEBI:9937 ! has primary input relationship: RO:0004009 CHEBI:9937 ! has primary input [Term] id: GO:0005009 name: insulin receptor activity namespace: molecular_function def: "Combining with insulin receptor ligand and transmitting the signal across the plasma membrane to initiate a change in cell activity." [ISBN:0198506732] synonym: "insulin-activated receptor activity" EXACT [] xref: EC:2.7.10.1 {source="skos:broadMatch"} xref: Reactome:R-HSA-74715 "Autophosphorylation of insulin receptor" is_a: GO:0004714 ! transmembrane receptor protein tyrosine kinase activity is_a: GO:0016500 ! protein-hormone receptor activity intersection_of: GO:0038023 ! signaling receptor activity intersection_of: RO:0004009 PR:000009054 ! has primary input preproinsulin relationship: BFO:0000050 GO:0008286 ! part of insulin receptor signaling pathway relationship: BFO:0000051 GO:0043559 ! has part insulin binding relationship: RO:0004009 PR:000009054 ! has primary input preproinsulin property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/23056" xsd:anyURI property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/28520" xsd:anyURI [Term] id: GO:0005044 name: scavenger receptor activity namespace: molecular_function def: "Combining with any modified low-density lipoprotein (LDL) or other polyanionic ligand and delivering the ligand into the cell via endocytosis. Ligands include acetylated and oxidized LDL, Gram-positive and Gram-negative bacteria, apoptotic cells, amyloid-beta fibrils, and advanced glycation end products (AGEs)." [GOC:bf, PMID:11790542, PMID:12379907, PMID:12621157, PMID:20981357] comment: Note that many gene products that are called scavenger receptors have a broad range of potential ligands and also can be annotated to 'pattern recognition receptor activity ; GO:0038187' or its child terms, or to 'lipoprotein receptor activity ; GO:0030228' or its child terms. For receptors that transduce a signal rather than endocytose their ligand, consider instead the terms 'signaling receptor activity ; GO:0038023' and its children. subset: goslim_chembl synonym: "macrophage receptor activity" NARROW [] is_a: GO:0038024 ! cargo receptor activity [Term] id: GO:0005102 name: signaling receptor binding namespace: molecular_function def: "Binding to one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function." [GOC:bf, GOC:ceb, ISBN:0198506732] comment: Where appropriate, also consider annotating to 'receptor agonist activity ; GO:0048018'. subset: goslim_agr subset: goslim_chembl subset: goslim_flybase_ribbon subset: goslim_mouse subset: goslim_plant synonym: "receptor binding" BROAD [] synonym: "receptor ligand" NARROW [] synonym: "receptor-associated protein activity" RELATED [] xref: Wikipedia:Ligand_(biochemistry) is_a: GO:0005515 ! protein binding [Term] id: GO:0005122 name: torso binding namespace: molecular_function def: "Binding to a torso (tor) protein, a receptor tyrosine kinase." [GOC:ceb, PMID:2927509] synonym: "tor binding" EXACT [] synonym: "tor ligand" NARROW [] synonym: "torso ligand" NARROW [] is_a: GO:0005102 ! signaling receptor binding intersection_of: GO:0005488 ! binding intersection_of: RO:0004009 PR:000001902 ! has primary input nuclear receptor ROR-gamma relationship: RO:0004009 PR:000001902 ! has primary input nuclear receptor ROR-gamma [Term] id: GO:0005126 name: cytokine receptor binding namespace: molecular_function def: "Binding to a cytokine receptor." [GOC:mah, GOC:vw] synonym: "hematopoietin/interferon-class (D200-domain) cytokine receptor binding" EXACT [GOC:add, GOC:mah] synonym: "hematopoietin/interferon-class (D200-domain) cytokine receptor ligand" NARROW [] is_a: GO:0005102 ! signaling receptor binding [Term] id: GO:0005172 name: vascular endothelial growth factor receptor binding namespace: molecular_function def: "Binding to a vascular endothelial growth factor receptor." [GOC:ai] synonym: "vascular endothelial growth factor" NARROW [] synonym: "vascular endothelial growth factor receptor ligand" NARROW [] synonym: "VEGF receptor binding" EXACT [] synonym: "VEGFR binding" EXACT [] is_a: GO:0005126 ! cytokine receptor binding is_a: GO:0070851 ! growth factor receptor binding intersection_of: GO:0005488 ! binding intersection_of: RO:0004009 PR:000001971 ! has primary input vascular endothelial growth factor receptor relationship: RO:0004009 PR:000001971 ! has primary input vascular endothelial growth factor receptor [Term] id: GO:0005173 name: stem cell factor receptor binding namespace: molecular_function def: "Binding to a stem cell factor receptor (SCFR), a type III transmembrane kinase receptor." [GOC:jl, PMID:10698217] synonym: "KIT binding" NARROW [] synonym: "SCF" NARROW [] synonym: "SCFR binding" EXACT [] synonym: "stem cell factor" NARROW [] synonym: "stem cell factor receptor ligand" NARROW [] is_a: GO:0005126 ! cytokine receptor binding intersection_of: GO:0005488 ! binding intersection_of: RO:0004009 PR:000002065 ! has primary input mast/stem cell growth factor receptor relationship: RO:0004009 PR:000002065 ! has primary input mast/stem cell growth factor receptor [Term] id: GO:0005215 name: transporter activity namespace: molecular_function def: "Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, accross or in between cells." [GOC:ai, GOC:dgf] comment: Some transporters, such as certain members of the SLC family, are referred to as 'carriers'; however GO uses carrier with a different meaning: a carrier binds to and transports the substance (see GO:0140104 molecular carrier activity), whereas a transporter forms some pore that allows the passing of molecules. subset: gocheck_do_not_annotate subset: goslim_agr subset: goslim_candida subset: goslim_chembl subset: goslim_euk_cellular_processes_ribbon subset: goslim_flybase_ribbon subset: goslim_generic subset: goslim_metagenomics subset: goslim_mouse subset: goslim_pir subset: goslim_plant subset: goslim_plant_ribbon subset: goslim_prokaryote subset: goslim_prokaryote_ribbon synonym: "carrier" RELATED [] is_a: GO:0003674 ! molecular_function property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/27621" xsd:anyURI [Term] id: GO:0005216 name: monoatomic ion channel activity namespace: molecular_function def: "Enables the facilitated diffusion of a monoatomic ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. May be either selective (it enables passage of a specific ion only) or non-selective (it enables passage of two or more ions of same charge but different size)." [GOC:cy, GOC:mtg_transport, GOC:pr, ISBN:0815340729] synonym: "ion channel activity" BROAD [] is_a: GO:0015075 ! monoatomic ion transmembrane transporter activity is_a: GO:0015267 ! channel activity intersection_of: GO:0015267 ! channel activity intersection_of: RO:0004009 CHEBI:24867 ! has primary input property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/24479" xsd:anyURI [Term] id: GO:0005227 name: calcium-activated cation channel activity namespace: molecular_function def: "Enables the transmembrane transfer of an inorganic cation by a channel that opens when a calcium cation has been bound by the channel complex or one of its constituent parts." [GOC:dph, GOC:mtg_transport] synonym: "calcium activated cation channel activity" EXACT [] synonym: "intracellular calcium-activated potassium channel" NARROW [] synonym: "polycystin" NARROW [] xref: Reactome:R-HSA-9717383 "TRPM4 transports Na+ from the extracellular region to the cytosol" is_a: GO:0022839 ! monoatomic ion-gated channel activity is_a: GO:0099094 ! ligand-gated monoatomic cation channel activity intersection_of: GO:0022836 ! gated channel activity intersection_of: RO:0004009 CHEBI:23906 ! has primary input intersection_of: RO:0012001 CHEBI:29108 ! has small molecule activator relationship: RO:0012001 CHEBI:29108 ! has small molecule activator property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/24605" xsd:anyURI property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/28979" xsd:anyURI [Term] id: GO:0005228 name: intracellular sodium-activated potassium channel activity namespace: molecular_function def: "Enables the transmembrane transfer of potassium by a channel that opens in response to stimulus by a sodium ion or ions. Transport by a channel involves facilitated diffusion of a solute (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel, without evidence for a carrier-mediated mechanism. Sodium activated potassium channels have distinctive properties, including a large single channel conductance, subconductance states, and a block of single channel currents at positive potentials, similar to inward rectification." [GOC:mtg_transport, PMID:12628167] synonym: "intracellular sodium activated potassium channel activity" EXACT [] is_a: GO:0005267 ! potassium channel activity is_a: GO:0022839 ! monoatomic ion-gated channel activity is_a: GO:0099094 ! ligand-gated monoatomic cation channel activity [Term] id: GO:0005230 name: extracellular ligand-gated monoatomic ion channel activity namespace: molecular_function def: "Enables the transmembrane transfer of an ion by a channel that opens when a specific extracellular ligand has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729] synonym: "extracellular ligand-gated ion channel activity" BROAD [] is_a: GO:0015276 ! ligand-gated monoatomic ion channel activity [Term] id: GO:0005231 name: excitatory extracellular ligand-gated monoatomic ion channel activity namespace: molecular_function def: "Enables the transmembrane transfer of an ion by a channel that opens when a specific extracellular ligand has been bound by the channel complex or one of its constituent parts, where channel opening contributes to an increase in membrane potential." [GOC:mah, ISBN:0323037070] xref: Reactome:R-HSA-399711 "Activation of Ca impermeable AMPA receptors" xref: Reactome:R-HSA-399712 "Activation of Ca permeable AMPA receptors" xref: Reactome:R-HSA-420980 "Activation of Ca permeable AMPA receptors" xref: Reactome:R-HSA-432164 "Ca2+ influx into the post-synaptic cell" xref: Reactome:R-HSA-438037 "Membrane depolarization upon activation of Ca impermeable AMPA receptors" is_a: GO:0005230 ! extracellular ligand-gated monoatomic ion channel activity intersection_of: GO:0005230 ! extracellular ligand-gated monoatomic ion channel activity intersection_of: BFO:0000050 GO:0060079 ! part of excitatory postsynaptic potential relationship: BFO:0000050 GO:0060079 ! part of excitatory postsynaptic potential [Term] id: GO:0005244 name: voltage-gated monoatomic ion channel activity namespace: molecular_function def: "Enables the transmembrane transfer of an ion by a voltage-gated channel. An ion is an atom or group of atoms carrying an electric charge by virtue of having gained or lost one or more electrons. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:mtg_transport, ISBN:0198506732, ISBN:0815340729] synonym: "voltage gated ion channel activity" EXACT [] synonym: "voltage-dependent ion channel activity" EXACT [] synonym: "voltage-gated ion channel activity" BROAD [] is_a: GO:0005216 ! monoatomic ion channel activity is_a: GO:0022832 ! voltage-gated channel activity intersection_of: GO:0022832 ! voltage-gated channel activity intersection_of: RO:0004009 CHEBI:24867 ! has primary input property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/24479" xsd:anyURI [Term] id: GO:0005245 name: voltage-gated calcium channel activity namespace: molecular_function def: "Enables the transmembrane transfer of a calcium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:mtg_transport, GOC:tb, ISBN:0815340729] synonym: "depolarization-activated calcium channel" BROAD [] synonym: "depolarization-activated voltage gated calcium channel activity" EXACT [] synonym: "depolarization-activated voltage-gated calcium channel" EXACT [] synonym: "depolarization-activated voltage-gated calcium channel activity" EXACT [] synonym: "dihydropyridine-sensitive calcium channel activity" NARROW [] synonym: "voltage gated calcium channel activity" EXACT [] synonym: "voltage-dependent calcium channel activity" EXACT [] synonym: "voltage-gated calcium ion channel activity" EXACT [] synonym: "voltage-sensitive calcium channel" EXACT [] xref: Reactome:R-HSA-265645 "Calcium Influx through Voltage-gated Calcium Channels" xref: Reactome:R-HSA-5577213 "LTCC multimer transports Ca2+ from extracellular region to cytosol" xref: Reactome:R-HSA-9701055 "TRPA1 tetramer transports Ca2+ from extracellular region to cytosol" xref: Reactome:R-HSA-9701141 "TRPV1 transports Ca2+ from extracellular region to cytosol" xref: Reactome:R-HSA-9905934 "CaV3.2 (CACNA1H:CACNA2D1:CACNB1,2,3:CACNG7) transports calcium from the extracellular region to the cytosol" is_a: GO:0005262 ! calcium channel activity is_a: GO:0022843 ! voltage-gated monoatomic cation channel activity intersection_of: GO:0022832 ! voltage-gated channel activity intersection_of: RO:0004009 CHEBI:29108 ! has primary input [Term] id: GO:0005248 name: voltage-gated sodium channel activity namespace: molecular_function def: "Enables the transmembrane transfer of a sodium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:mtg_transport, ISBN:0815340729] synonym: "voltage gated sodium channel activity" EXACT [] synonym: "voltage-dependent sodium channel activity" EXACT [] synonym: "voltage-gated sodium ion channel activity" EXACT [] synonym: "voltage-sensitive sodium channel" EXACT [] xref: Reactome:R-HSA-5576895 "SCNAs:SNCBs transport Na+ from extracellular region to cytosol" is_a: GO:0005272 ! sodium channel activity [Term] id: GO:0005249 name: voltage-gated potassium channel activity namespace: molecular_function def: "Enables the transmembrane transfer of a potassium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:mtg_transport, ISBN:0815340729] synonym: "voltage gated potassium channel activity" EXACT [] synonym: "voltage-dependent potassium channel activity" EXACT [] synonym: "voltage-gated potassium ion channel activity" EXACT [] synonym: "voltage-sensitive potassium channel" EXACT [] xref: Reactome:R-HSA-1296127 "Activation of voltage gated Potassium channels" xref: Reactome:R-HSA-9659554 "KCNQ4 transports K+ from the cytosol to the extracellular region" xref: Reactome:R-HSA-9667761 "KCNMA1:KCNMB1:LRRC52 transports K+ from the cytosol to the extracellular region" is_a: GO:0005267 ! potassium channel activity is_a: GO:0022843 ! voltage-gated monoatomic cation channel activity intersection_of: GO:0022832 ! voltage-gated channel activity intersection_of: RO:0004009 CHEBI:29103 ! has primary input [Term] id: GO:0005261 name: monoatomic cation channel activity namespace: molecular_function def: "Enables the energy-independent facilitated diffusion of a monoatomic cation through a transmembrane aqueous pore or channel." [GOC:def, GOC:dph, GOC:mtg_transport, GOC:pr, ISBN:0815340729] synonym: "cation channel activity" BROAD [] synonym: "cation diffusion facilitator activity" EXACT [] synonym: "non-selective cation channel activity" NARROW [] xref: Reactome:R-HSA-1296043 "Activation of HCN channels" xref: Reactome:R-HSA-2089943 "TRPC1 translocates calcium from the extracellular region to the cytosol" xref: Reactome:R-HSA-426223 "Cation influx mediated by TRPC3/6/7" xref: Reactome:R-HSA-9706720 "SARS-CoV-1 E transports Ca2+" xref: Reactome:R-HSA-9712190 "cAMP:olfactory CNG channel translocates Na+ and Ca2+ from the extracellular region to the cytosol" xref: Reactome:R-HSA-9754616 "SARS-CoV-2 E pentamer transports Ca2+" xref: Reactome:R-HSA-9837835 "SH pentamer transports K+" is_a: GO:0005216 ! monoatomic ion channel activity is_a: GO:0008324 ! monoatomic cation transmembrane transporter activity intersection_of: GO:0015267 ! channel activity intersection_of: RO:0004009 CHEBI:23906 ! has primary input property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/24479" xsd:anyURI [Term] id: GO:0005262 name: calcium channel activity namespace: molecular_function def: "Enables the energy-independent facilitated diffusion of a calcium ion through a transmembrane aqueous pore or channel." [GOC:mtg_transport, GOC:pr, ISBN:0815340729] xref: Reactome:R-HSA-139854 "IP3R tetramer:I(1,4,5)P3:4xCa2+ transports Ca2+ from platelet dense tubular system to cytosol" xref: Reactome:R-HSA-139855 "P2X1-mediated entry of Ca++ from plasma" xref: Reactome:R-HSA-210420 "Ca2+ influx through voltage gated Ca2+ channels" xref: Reactome:R-HSA-3295579 "TRPs transport extracellular Ca2+ to cytosol" xref: Reactome:R-HSA-8949145 "VDAC1,2,3 translocate calcium from the cytosol to the mitochondrial intermembrane space" xref: Reactome:R-HSA-8949178 "MCU translocates calcium from the mitochondrial intermembrane space to the mitochondrial matrix" xref: Reactome:R-HSA-9663785 "CHRNA9:CHRNA10:AcCho transports Ca2+ from the extracellular region to the cytosol" xref: Reactome:R-HSA-9858800 "TRPV4 tetramer:CALM1:Ca2+ transports calcium ions (Ca2+) from the extracellular region to the cytosol" xref: RHEA:29671 {source="skos:broadMatch"} is_a: GO:0005261 ! monoatomic cation channel activity is_a: GO:0015085 ! calcium ion transmembrane transporter activity intersection_of: GO:0015267 ! channel activity intersection_of: RO:0004009 CHEBI:29108 ! has primary input property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/27521" xsd:anyURI [Term] id: GO:0005267 name: potassium channel activity namespace: molecular_function def: "Enables the energy-independent facilitated diffusion of a potassium ion through a transmembrane aqueous pore or channel." [GOC:BHF, GOC:mtg_transport, GOC:pr, ISBN:0815340729] xref: Reactome:R-HSA-1296024 "Activation of ATP sensitive Potassium channels in neuroendocrine cells" xref: Reactome:R-HSA-1296035 "Activation of Ca2+ activated Potassium channels with Intermediate conductance" xref: Reactome:R-HSA-1296037 "Activation of Ca2+ activated Potassium channels with large conductance" xref: Reactome:R-HSA-1296039 "Activation of Ca2+ activated Potassium channels with small conductance" xref: Reactome:R-HSA-1296348 "Activation of TWIK-related K+ channel (TREK)" xref: Reactome:R-HSA-1299297 "Activation of THIK" xref: Reactome:R-HSA-1299304 "Activation of tandem pore domain in a weak inwardly rectifying K+ channels" xref: Reactome:R-HSA-1299318 "Activation of TASK" xref: Reactome:R-HSA-1299338 "Activation of TRESK" xref: Reactome:R-HSA-1299359 "Activation of TALK" xref: Reactome:R-HSA-2534365 "Slo3 Potassium Transport" xref: Reactome:R-HSA-5578910 "KCNK dimers transport K+ from cytosol to extracellular region" xref: RHEA:29463 {source="skos:broadMatch"} is_a: GO:0005261 ! monoatomic cation channel activity is_a: GO:0015079 ! potassium ion transmembrane transporter activity intersection_of: GO:0015267 ! channel activity intersection_of: RO:0004009 CHEBI:29103 ! has primary input property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/27521" xsd:anyURI [Term] id: GO:0005272 name: sodium channel activity namespace: molecular_function def: "Enables the energy-independent facilitated diffusion of a sodium ion through a transmembrane aqueous pore or channel." [GOC:BHF, GOC:mtg_transport, GOC:pr, ISBN:0815340729] xref: Reactome:R-HSA-2730664 "UNC79:UNC80:NALCN transports Na+ extracellular region to cytosol" xref: Reactome:R-HSA-3295580 "TRPM4,5 transport extracellular Na+ to cytosol" xref: Reactome:R-HSA-9717374 "SCN3A:SCN2B,4B transports Na+ from the extracellular region to the cytosol" xref: Reactome:R-HSA-9717382 "SCN9A:SCN1B,2B,4B transports Na+ from the extracellular region to the cytosol" xref: Reactome:R-HSA-9717395 "TRPM5 transports Na+ from the extracellular region to the cytosol" xref: Reactome:R-HSA-9717396 "SCN2A:SCN1B,2B,4B transports Na+ from the extracellular region to the cytosol" xref: RHEA:34963 {source="skos:broadMatch"} is_a: GO:0005261 ! monoatomic cation channel activity is_a: GO:0015081 ! sodium ion transmembrane transporter activity intersection_of: GO:0015267 ! channel activity intersection_of: RO:0004009 CHEBI:29101 ! has primary input property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/27521" xsd:anyURI [Term] id: GO:0005275 name: amine transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of amines, including polyamines, from one side of a membrane to the other. Amines are organic compounds that are weakly basic in character and contain an amino (-NH2) or substituted amino group." [GOC:mtg_transport, ISBN:0198506732, ISBN:0815340729] synonym: "amine/amide/polyamine channel activity" BROAD [] synonym: "amine/polyamine transmembrane transporter activity" EXACT [] synonym: "amino acid-polyamine transmembrane transporter activity" EXACT [] is_a: GO:0022857 ! transmembrane transporter activity intersection_of: GO:0022857 ! transmembrane transporter activity intersection_of: RO:0004009 CHEBI:32952 ! has primary input relationship: BFO:0000050 GO:0015837 ! part of amine transport relationship: RO:0004009 CHEBI:32952 ! has primary input [Term] id: GO:0005277 name: acetylcholine transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of acetylcholine from one side of a membrane to the other. Acetylcholine is an acetic acid ester of the organic base choline and functions as a neurotransmitter, released at the synapses of parasympathetic nerves and at neuromuscular junctions." [GOC:ai] xref: Reactome:R-HSA-264615 "Loading of acetylcholine in synaptic vesicles" is_a: GO:0005326 ! neurotransmitter transmembrane transporter activity is_a: GO:1901375 ! acetate ester transmembrane transporter activity intersection_of: GO:0022857 ! transmembrane transporter activity intersection_of: RO:0004009 CHEBI:15355 ! has primary input relationship: RO:0004009 CHEBI:15355 ! has primary input [Term] id: GO:0005290 name: L-histidine transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of L-histidine from one side of a membrane to the other. L-histidine is 2-amino-3-(1H-imidazol-4-yl)propanoic acid." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] synonym: "histidine/arginine/lysine/ornithine porter activity" NARROW [] synonym: "L-histidine transporter activity" BROAD [] is_a: GO:0015173 ! aromatic amino acid transmembrane transporter activity is_a: GO:0015174 ! basic amino acid transmembrane transporter activity is_a: GO:0015179 ! L-amino acid transmembrane transporter activity is_a: GO:1901474 ! azole transmembrane transporter activity intersection_of: GO:0022857 ! transmembrane transporter activity intersection_of: RO:0004009 CHEBI:57595 ! has primary input relationship: BFO:0000050 GO:0089709 ! part of L-histidine transmembrane transport relationship: RO:0004009 CHEBI:57595 ! has primary input [Term] id: GO:0005313 name: L-glutamate transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of L-glutamate from one side of a membrane to the other. L-glutamate is the anion of 2-aminopentanedioic acid." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] synonym: "glutamate transmembrane transporter activity" BROAD [] synonym: "glutamate/aspartate porter activity" NARROW [] synonym: "glutamate/aspartate:sodium symporter activity" NARROW [] synonym: "L-glutamate transporter activity" BROAD [] xref: Reactome:R-HSA-210444 "L-Glutamate loading of synaptic vesicle" xref: Reactome:R-HSA-428052 "SLC17A6,7,8 exchange cytosolic L-Glu for synaptic vesicle H+" xref: Reactome:R-HSA-5624256 "Defective SLC17A8 does not exchange cytosolic L-Glu for synaptic vesicle H+" is_a: GO:0015172 ! acidic amino acid transmembrane transporter activity is_a: GO:0015179 ! L-amino acid transmembrane transporter activity intersection_of: GO:0022857 ! transmembrane transporter activity intersection_of: RO:0004009 CHEBI:29985 ! has primary input relationship: BFO:0000050 GO:0015813 ! part of L-glutamate transmembrane transport relationship: RO:0004009 CHEBI:29985 ! has primary input property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/27521" xsd:anyURI [Term] id: GO:0005315 name: phosphate transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of phosphate ions from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Secondary active transporters include symporters and antiporters." [GOC:mtg_transport] synonym: "inorganic phosphate transmembrane transporter activity" EXACT [] is_a: GO:0015291 ! secondary active transmembrane transporter activity intersection_of: GO:0022857 ! transmembrane transporter activity intersection_of: RO:0004009 CHEBI:43474 ! has primary input relationship: RO:0004009 CHEBI:43474 ! has primary input property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/27121" xsd:anyURI property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/27521" xsd:anyURI [Term] id: GO:0005319 name: lipid transporter activity namespace: molecular_function def: "Enables the directed movement of lipids into, out of or within a cell, or between cells." [GOC:ai] synonym: "apolipoprotein" RELATED [] synonym: "lipophorin" NARROW [] xref: Reactome:R-HSA-1369028 "ABCAs mediate lipid efflux" xref: Reactome:R-HSA-1369052 "ABCAs mediate lipid influx" xref: Reactome:R-HSA-174786 "ApoB-48 + 40 triacylglycerol + 60 phospholipid => ApoB-48:TG:PL complex" xref: Reactome:R-HSA-5334794 "FABPs bind LCFAs" xref: Reactome:R-HSA-5682285 "ABCA12 transports lipids from cytosol to extracellular region" xref: Reactome:R-HSA-5682311 "Defective ABCA12 does not transport lipids from cytosol to extracellular region" xref: Reactome:R-HSA-5683672 "Defective ABCA3 does not transport PC, PG from ER membrane to lamellar body" xref: Reactome:R-HSA-5683714 "ABCA3 transports PC, PG from ER membrane to lamellar body" xref: Reactome:R-HSA-5688397 "Defective ABCA3 does not transport PC, PG from ER membrane to lamellar body" xref: Reactome:R-HSA-6801250 "TRIAP1:PRELID1, PRELID3A transports PA from the outer to the inner mitochondrial membrane" xref: Reactome:R-HSA-8848053 "ABCA5 transports CHOL from lysosomal lumen to cytosol" xref: Reactome:R-HSA-8866329 "MTTP lipidates APOB-100, forming a pre-VLDL" xref: Reactome:R-HSA-8873834 "STARD10 transports PC from ER membrane to lamellar body membrane" is_a: BFO:0000003 is_a: GO:0005215 ! transporter activity intersection_of: GO:0005215 ! transporter activity intersection_of: RO:0004009 CHEBI:18059 ! has primary input relationship: BFO:0000050 GO:0006869 {source="GO_REF:0000090"} ! part of lipid transport relationship: RO:0004009 CHEBI:18059 ! has primary input [Term] id: GO:0005326 name: neurotransmitter transmembrane transporter activity namespace: molecular_function def: "Enables the directed movement of a neurotransmitter into, out of or within a cell, or between cells. Neurotransmitters are any chemical substance that is capable of transmitting (or inhibiting the transmission of) a nerve impulse from a neuron to another cell." [GOC:ai, ISBN:0198506732] synonym: "neurotransmitter transporter activity" RELATED [] xref: Reactome:R-HSA-374896 "Uptake of Noradrenaline" xref: Reactome:R-HSA-374919 "Noradrenaline clearance from the synaptic cleft" is_a: GO:0022857 ! transmembrane transporter activity relationship: BFO:0000050 GO:0006836 {source="GO_REF:0000090"} ! part of neurotransmitter transport relationship: RO:0002162 NCBITaxon:6072 ! in taxon Eumetazoa [Term] id: GO:0005346 name: purine ribonucleotide transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of a purine ribonucleotide, any compound consisting of a purine ribonucleoside (a purine organic base attached to a ribose sugar) esterified with (ortho)phosphate, from one side of a membrane to the other." [GOC:ai] is_a: GO:0015216 ! purine nucleotide transmembrane transporter activity is_a: GO:1901505 ! carbohydrate derivative transmembrane transporter activity intersection_of: GO:0022857 ! transmembrane transporter activity intersection_of: RO:0004009 CHEBI:26400 ! has primary input relationship: RO:0004009 CHEBI:26400 ! has primary input [Term] id: GO:0005347 name: ATP transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of ATP, adenosine triphosphate, from one side of a membrane to the other." [GOC:ai] xref: Reactome:R-HSA-9717392 "CALHM1:CALHM3 transports ATP from the cytosol to the extracellular region" is_a: GO:0000295 ! adenine nucleotide transmembrane transporter activity is_a: GO:0005346 ! purine ribonucleotide transmembrane transporter activity intersection_of: GO:0022857 ! transmembrane transporter activity intersection_of: RO:0004009 CHEBI:30616 ! has primary input relationship: BFO:0000050 GO:0015867 ! part of ATP transport relationship: RO:0004009 CHEBI:30616 ! has primary input [Term] id: GO:0005372 name: water transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of water (H2O) from one side of a membrane to the other." [GOC:ai] is_a: GO:0022857 ! transmembrane transporter activity intersection_of: GO:0022857 ! transmembrane transporter activity intersection_of: RO:0004009 CHEBI:15377 ! has primary input relationship: BFO:0000050 GO:0006833 ! part of water transport relationship: RO:0004009 CHEBI:15377 ! has primary input [Term] id: GO:0005381 name: iron ion transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of iron (Fe) ions from one side of a membrane to the other." [GOC:ai] comment: An example of this is mouse ferroportin (UniProtKB:Q9JHI9), which transports iron out of the cell. synonym: "iron cation channel activity" EXACT [] synonym: "iron channel activity" EXACT [] synonym: "iron transporter activity" EXACT [] synonym: "multicopper ferroxidase iron transport mediator activity" RELATED [] synonym: "transmembrane iron ion permease activity" EXACT [] synonym: "transmembrane iron permease activity" EXACT [] synonym: "zinc, iron permease activity" RELATED [] xref: Reactome:R-HSA-435349 "SLC11A2 cotransports Fe2+, H+ from extracellular region to cytosol" xref: Reactome:R-HSA-5623558 "Defective SLC11A2 does not cotransport Fe2+, H+ from extracellular region to cytosol" xref: Reactome:R-HSA-5655733 "Defective SLC40A1 does not transport Fe2+ from cytosol to extracellular region" xref: Reactome:R-HSA-904830 "SLC40A1:CP:6Cu2+ transports Fe2+ from cytosol to extracellular region" xref: Reactome:R-HSA-917936 "MCOLN1 transports Fe2+ from endosome lumen to cytosol" is_a: GO:0046915 ! transition metal ion transmembrane transporter activity intersection_of: GO:0022857 ! transmembrane transporter activity intersection_of: RO:0004009 CHEBI:24875 ! has primary input relationship: BFO:0000050 GO:0034755 ! part of iron ion transmembrane transport relationship: RO:0004009 CHEBI:24875 ! has primary input property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/17162" xsd:anyURI [Term] id: GO:0005488 name: binding namespace: molecular_function def: "The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732] subset: goslim_pir subset: goslim_plant synonym: "ligand" NARROW [] xref: Wikipedia:Binding_(molecular) is_a: GO:0003674 ! molecular_function [Term] id: GO:0005496 name: steroid binding namespace: molecular_function def: "Binding to a steroid, any of a large group of substances that have in common a ring system based on 1,2-cyclopentanoperhydrophenanthrene." [GOC:jl, ISBN:0198506732] subset: goslim_pir is_a: GO:0008289 ! lipid binding intersection_of: GO:0005488 ! binding intersection_of: RO:0004009 CHEBI:35341 ! has primary input relationship: RO:0004009 CHEBI:35341 ! has primary input [Term] id: GO:0005500 name: juvenile hormone binding namespace: molecular_function def: "Binding to a juvenile hormone, a sesquiterpenoid derivative that function to maintain the larval state of insects at molting and that may be required for other processes, e.g. oogenesis." [GOC:jl, ISBN:0198506732] is_a: GO:0019840 ! isoprenoid binding is_a: GO:0042562 ! hormone binding intersection_of: GO:0005488 ! binding intersection_of: RO:0004009 CHEBI:24943 ! has primary input relationship: RO:0004009 CHEBI:24943 ! has primary input [Term] id: GO:0005504 name: fatty acid binding namespace: molecular_function def: "Binding to a fatty acid, an aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis." [ISBN:0198506732] is_a: GO:0008289 ! lipid binding is_a: GO:0033293 ! monocarboxylic acid binding intersection_of: GO:0005488 ! binding intersection_of: RO:0004009 CHEBI:28868 ! has primary input relationship: RO:0004009 CHEBI:28868 ! has primary input [Term] id: GO:0005506 name: iron ion binding namespace: molecular_function def: "Binding to an iron (Fe) ion." [GOC:ai] synonym: "iron binding" EXACT [] is_a: GO:0046914 ! transition metal ion binding intersection_of: GO:0005488 ! binding intersection_of: RO:0004009 CHEBI:24875 ! has primary input relationship: RO:0004009 CHEBI:24875 ! has primary input [Term] id: GO:0005509 name: calcium ion binding namespace: molecular_function def: "Binding to a calcium ion (Ca2+)." [GOC:ai] synonym: "calcium ion storage activity" RELATED [] is_a: GO:0046872 ! metal ion binding intersection_of: GO:0005488 ! binding intersection_of: RO:0004009 CHEBI:29108 ! has primary input relationship: RO:0004009 CHEBI:29108 ! has primary input [Term] id: GO:0005515 name: protein binding namespace: molecular_function def: "Binding to a protein." [GOC:go_curators] subset: goslim_candida subset: goslim_chembl subset: goslim_euk_cellular_processes_ribbon subset: goslim_metagenomics subset: goslim_pir subset: goslim_plant subset: goslim_plant_ribbon subset: goslim_prokaryote_ribbon synonym: "glycoprotein binding" NARROW [] synonym: "protein amino acid binding" EXACT [] xref: Reactome:R-HSA-9866132 "Intermediate II binds CYC1, UQCRC1, UQCRC2, UQCRH" is_a: BFO:0000003 is_a: GO:0005488 ! binding intersection_of: GO:0005488 ! binding intersection_of: RO:0004009 PR:000000001 ! has primary input protein relationship: RO:0004009 PR:000000001 ! has primary input protein [Term] id: GO:0005518 name: collagen binding namespace: molecular_function def: "Binding to collagen, a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals. Collagen is highly enriched in glycine (some regions are 33% glycine) and proline, occurring predominantly as 3-hydroxyproline (about 20%)." [GOC:ai, ISBN:0198506732] is_a: GO:0044877 ! protein-containing complex binding intersection_of: GO:0005488 ! binding intersection_of: RO:0004009 GO:0005581 ! has primary input collagen trimer relationship: RO:0004009 GO:0005581 ! has primary input collagen trimer [Term] id: GO:0005524 name: ATP binding namespace: molecular_function def: "Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] synonym: "Mg-ATP binding" EXACT [] synonym: "MgATP binding" EXACT [] xref: Reactome:R-HSA-265682 "KCNJ11 tetramer:ABCC8 tetramer binds 4xATP, closing the channel" is_a: GO:0032559 ! adenyl ribonucleotide binding is_a: GO:0035639 ! purine ribonucleoside triphosphate binding intersection_of: GO:0005488 ! binding intersection_of: RO:0004009 CHEBI:30616 ! has primary input relationship: RO:0004009 CHEBI:30616 ! has primary input [Term] id: GO:0005536 name: D-glucose binding namespace: molecular_function def: "Binding to D-enantiomers of glucose." [GOC:jl] synonym: "glucose binding" BROAD [] is_a: GO:0048029 ! monosaccharide binding intersection_of: GO:0005488 ! binding intersection_of: RO:0004009 CHEBI:4167 ! has primary input relationship: RO:0004009 CHEBI:4167 ! has primary input [Term] id: GO:0005539 name: glycosaminoglycan binding namespace: molecular_function def: "Binding to a glycan (polysaccharide) containing a substantial proportion of aminomonosaccharide residues." [GOC:jl, ISBN:0198506732] subset: goslim_chembl is_a: GO:0097367 ! carbohydrate derivative binding intersection_of: GO:0005488 ! binding intersection_of: RO:0004009 CHEBI:18085 ! has primary input relationship: RO:0004009 CHEBI:18085 ! has primary input [Term] id: GO:0005540 name: hyaluronic acid binding namespace: molecular_function def: "Binding to hyaluronic acid, a polymer composed of repeating dimeric units of glucuronic acid and N-acetyl glucosamine." [GOC:jl] synonym: "hyaluronan binding" EXACT [] is_a: GO:0005539 ! glycosaminoglycan binding intersection_of: GO:0005488 ! binding intersection_of: RO:0004009 CHEBI:16336 ! has primary input relationship: RO:0004009 CHEBI:16336 ! has primary input [Term] id: GO:0005575 name: cellular_component namespace: cellular_component def: "A location, relative to cellular compartments and structures, occupied by a macromolecular machine. There are three types of cellular components described in the gene ontology: (1) the cellular anatomical entity where a gene product carries out a molecular function (e.g., plasma membrane, cytoskeleton) or membrane-enclosed compartments (e.g., mitochondrion); (2) virion components, where viral proteins act, and (3) the stable macromolecular complexes of which gene product are parts (e.g., the clathrin complex)." [GOC:pdt] comment: Note that, in addition to forming the root of the cellular component ontology, this term is recommended for the annotation of gene products whose cellular component is unknown. When this term is used for annotation, it indicates that no information was available about the cellular component of the gene product annotated as of the date the annotation was made; the evidence code 'no data' (ND), is used to indicate this. subset: goslim_candida subset: goslim_chembl subset: goslim_metagenomics subset: goslim_pir subset: goslim_plant subset: goslim_yeast synonym: "cell or subcellular entity" EXACT [] synonym: "cellular component" EXACT [] synonym: "subcellular entity" RELATED [NIF_Subcellular:nlx_subcell_100315] xref: NIF_Subcellular:sao1337158144 is_a: BFO:0000040 disjoint_from: GO:0008150 ! biological_process property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/17729" xsd:anyURI [Term] id: GO:0005576 name: extracellular region namespace: cellular_component def: "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] comment: Note that this term is intended to annotate gene products that are not attached to the cell surface. For gene products from multicellular organisms which are secreted from a cell but retained within the organism (i.e. released into the interstitial fluid or blood), consider the cellular component term 'extracellular space ; GO:0005615'. subset: goslim_agr subset: goslim_candida subset: goslim_chembl subset: goslim_euk_cellular_processes_ribbon subset: goslim_flybase_ribbon subset: goslim_generic subset: goslim_metagenomics subset: goslim_mouse subset: goslim_pir subset: goslim_plant subset: goslim_plant_ribbon subset: goslim_prokaryote subset: goslim_prokaryote_ribbon subset: goslim_yeast synonym: "extracellular" EXACT [] xref: Wikipedia:Extracellular is_a: GO:0110165 ! cellular anatomical structure [Term] id: GO:0005577 name: fibrinogen complex namespace: cellular_component def: "A highly soluble, elongated protein complex found in blood plasma and involved in clot formation. It is converted into fibrin monomer by the action of thrombin. In the mouse, fibrinogen is a hexamer, 46 nm long and 9 nm maximal diameter, containing two sets of nonidentical chains (alpha, beta, and gamma) linked together by disulfide bonds." [ISBN:0198547684] synonym: "fibrinogen" EXACT [] synonym: "fibrinogen alpha chain" NARROW [] synonym: "fibrinogen beta chain" NARROW [] synonym: "fibrinogen gamma chain" NARROW [] is_a: BFO:0000004 is_a: GO:0032991 ! protein-containing complex relationship: BFO:0000050 GO:0005615 ! part of extracellular space property_value: RO:0002161 NCBITaxon:4890 [Term] id: GO:0005581 name: collagen trimer namespace: cellular_component def: "A protein complex consisting of three collagen chains assembled into a left-handed triple helix. These trimers typically assemble into higher order structures." [GOC:dos, GOC:mah, PMID:19693541, PMID:21421911] xref: Wikipedia:Collagen is_a: GO:0032991 ! protein-containing complex relationship: RO:0002162 NCBITaxon:33208 ! in taxon Metazoa [Term] id: GO:0005583 name: fibrillar collagen trimer namespace: cellular_component def: "Any triple helical collagen trimer that forms fibrils." [PMID:21421911] is_a: BFO:0000004 is_a: GO:0005581 ! collagen trimer intersection_of: GO:0005581 ! collagen trimer intersection_of: BFO:0000050 GO:0098643 ! part of fibrillar collagen disjoint_from: GO:0030936 ! transmembrane collagen trimer relationship: BFO:0000050 GO:0098643 ! part of fibrillar collagen [Term] id: GO:0005584 name: collagen type I trimer namespace: cellular_component def: "A collagen trimer containing alpha(I) chains. The most common form of type I collagen is a heterotrimer containing two alpha1(I) chains and one alpha2(I) chain; homotrimers containing three alpha1(I) chains are also found. Type I collagen triple helices associate to form banded fibrils." [PMID:21421911] xref: Wikipedia:Collagen_type_I is_a: GO:0005583 ! fibrillar collagen trimer [Term] id: GO:0005585 name: collagen type II trimer namespace: cellular_component def: "A collagen homotrimer of alpha1(II) chains; type II collagen triple helices associate to form fibrils." [PMID:21421911] xref: Wikipedia:Collagen_type_II is_a: GO:0005583 ! fibrillar collagen trimer [Term] id: GO:0005587 name: collagen type IV trimer namespace: cellular_component def: "A collagen heterotrimer containing type IV alpha chains; [alpha1(IV)]2alpha2(IV) trimers are commonly observed, although more type IV alpha chains exist and may be present in type IV trimers; type IV collagen triple helices associate to form 3 dimensional nets within basement membranes." [PMID:19693541, PMID:21421911] xref: Wikipedia:Collagen_type_IV is_a: GO:0098642 ! network-forming collagen trimer relationship: BFO:0000050 GO:0140154 ! part of chicken-wire-like collagen network property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/30148" xsd:anyURI [Term] id: GO:0005604 name: basement membrane namespace: cellular_component def: "A collagen-containing extracellular matrix consisting of a thin layer of dense material found in various animal tissues interposed between the cells and the adjacent connective tissue. It consists of the basal lamina plus an associated layer of reticulin fibers." [PMID:22505934, PMID:33605520, PMID:39223427] comment: Note that this term has no relationship to 'membrane ; GO:0016020' because the basement membrane is not a lipid bilayer. synonym: "basal lamina" RELATED [] synonym: "basement lamina" RELATED [] synonym: "lamina densa" RELATED [] xref: Wikipedia:Basement_membrane is_a: GO:0031012 ! extracellular matrix property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/29267" xsd:anyURI property_value: skos:prefLabel "basement membrane" xsd:string [Term] id: GO:0005614 name: interstitial matrix namespace: cellular_component def: "A type of extracellular matrix found in interstitial connective tissue, characterized by the presence of fibronectins, proteoglycans, and types I, III, V, VI, VII and XII collagens." [PMID:33605520, PMID:39223427, PMID:8450001] is_a: GO:0031012 ! extracellular matrix property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/29267" xsd:anyURI [Term] id: GO:0005615 name: extracellular space namespace: cellular_component def: "That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684] comment: Note that for multicellular organisms, the extracellular space refers to everything outside a cell, but still within the organism (excluding the extracellular matrix). Gene products from a multi-cellular organism that are secreted from a cell into the interstitial fluid or blood can therefore be annotated to this term. subset: goslim_chembl subset: goslim_drosophila subset: goslim_generic synonym: "intercellular space" RELATED [] xref: NIF_Subcellular:sao1425028079 is_a: GO:0110165 ! cellular anatomical structure relationship: BFO:0000050 GO:0005576 ! part of extracellular region property_value: RO:0002161 NCBITaxon:4890 [Term] id: GO:0005622 name: intracellular anatomical structure namespace: cellular_component def: "A component of a cell contained within (but not including) the plasma membrane. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732] subset: gocheck_do_not_annotate subset: goslim_chembl subset: goslim_metagenomics subset: goslim_plant synonym: "internal to cell" EXACT [] synonym: "intracellular" EXACT [] synonym: "nucleocytoplasm" RELATED [GOC:mah] synonym: "protoplasm" EXACT [] synonym: "protoplast" RELATED [GOC:mah] xref: Wikipedia:Intracellular is_a: GO:0110165 ! cellular anatomical structure relationship: BFO:0000050 CL:0000000 ! part of cell property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/17776" xsd:anyURI property_value: skos:prefLabel "intracellular anatomical structure" xsd:string [Term] id: GO:0005634 name: nucleus namespace: cellular_component def: "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] subset: goslim_agr subset: goslim_candida subset: goslim_chembl subset: goslim_drosophila subset: goslim_euk_cellular_processes_ribbon subset: goslim_flybase_ribbon subset: goslim_generic subset: goslim_metagenomics subset: goslim_mouse subset: goslim_pir subset: goslim_plant subset: goslim_plant_ribbon subset: goslim_yeast synonym: "cell nucleus" EXACT [] synonym: "horsetail nucleus" NARROW [GOC:al, GOC:mah, GOC:vw, PMID:15030757] xref: NIF_Subcellular:sao1702920020 xref: Wikipedia:Cell_nucleus is_a: GO:0043231 ! intracellular membrane-bounded organelle disjoint_from: GO:0005737 ! cytoplasm disjoint_from: GO:0005829 ! cytosol relationship: RO:0002162 NCBITaxon:2759 ! in taxon Eukaryota property_value: skos:prefLabel "nucleus" xsd:string [Term] id: GO:0005635 name: nuclear envelope namespace: cellular_component def: "The double lipid bilayer that encloses the nucleus, separating its contents from the cytoplasm. It consists of an inner and outer nuclear membrane, with an intermembrane space (20-40 nm wide, also called the perinuclear space) between them. The envelope is supported by the nuclear lamina and contains nuclear pore complexes, which regulate molecular transport." [ISBN:0198547684, PMID:16164970] subset: goslim_chembl subset: goslim_generic subset: goslim_plant xref: Wikipedia:Nuclear_envelope is_a: GO:0031967 ! organelle envelope relationship: BFO:0000050 GO:0005634 ! part of nucleus relationship: BFO:0000050 GO:0012505 ! part of endomembrane system property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/29832" xsd:anyURI [Term] id: GO:0005640 name: nuclear outer membrane namespace: cellular_component def: "The outer, i.e. cytoplasm-facing, lipid bilayer of the nuclear envelope; continuous with the endoplasmic reticulum of the cell and sometimes studded with ribosomes." [ISBN:0198547684] synonym: "nucleus outer envelope" EXACT [] synonym: "perinuclear membrane" EXACT [] xref: NIF_Subcellular:sao1617136075 is_a: GO:0031965 ! nuclear membrane is_a: GO:0031968 ! organelle outer membrane intersection_of: GO:0016020 ! membrane intersection_of: RO:0002007 GO:0005634 ! bounding layer of nucleus relationship: BFO:0000050 GO:0042175 ! part of nuclear outer membrane-endoplasmic reticulum membrane network relationship: RO:0002007 GO:0005634 ! bounding layer of nucleus [Term] id: GO:0005677 name: chromatin silencing complex namespace: cellular_component def: "Any protein complex that mediates changes in chromatin structure that result in transcriptional silencing." [GOC:mah] is_a: GO:0140513 ! nuclear protein-containing complex intersection_of: GO:0032991 ! protein-containing complex intersection_of: RO:0002216 GO:0031507 ! capable of part of heterochromatin formation relationship: RO:0002216 GO:0031507 ! capable of part of heterochromatin formation [Term] id: GO:0005694 name: chromosome namespace: cellular_component def: "A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information." [ISBN:0198547684] comment: Chromosomes include parts that are not part of the chromatin. Examples include the kinetochore. subset: goslim_agr subset: goslim_candida subset: goslim_chembl subset: goslim_drosophila subset: goslim_flybase_ribbon subset: goslim_generic subset: goslim_metagenomics subset: goslim_pir subset: goslim_prokaryote subset: goslim_prokaryote_ribbon subset: goslim_yeast synonym: "chromatid" RELATED [] synonym: "interphase chromosome" NARROW [] synonym: "prophase chromosome" NARROW [] xref: Wikipedia:Chromosome is_a: GO:0043232 ! intracellular membraneless organelle property_value: skos:prefLabel "chromosome" xsd:string [Term] id: GO:0005730 name: nucleolus namespace: cellular_component def: "A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome." [ISBN:0198506732] subset: goslim_candida subset: goslim_chembl subset: goslim_drosophila subset: goslim_generic subset: goslim_pir subset: goslim_plant subset: goslim_yeast xref: NIF_Subcellular:sao1820400233 xref: Wikipedia:Nucleolus is_a: GO:0043232 ! intracellular membraneless organelle relationship: BFO:0000050 GO:0031981 ! part of nuclear lumen property_value: skos:prefLabel "nucleolus" xsd:string [Term] id: GO:0005737 name: cytoplasm namespace: cellular_component def: "The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] subset: goslim_candida subset: goslim_chembl subset: goslim_metagenomics subset: goslim_pir subset: goslim_plant subset: goslim_plant_ribbon subset: goslim_prokaryote subset: goslim_prokaryote_ribbon subset: goslim_yeast xref: Wikipedia:Cytoplasm is_a: GO:0110165 ! cellular anatomical structure relationship: BFO:0000050 GO:0005622 ! part of intracellular anatomical structure property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/23023" xsd:anyURI property_value: skos:prefLabel "cytoplasm" xsd:string [Term] id: GO:0005739 name: mitochondrion namespace: cellular_component def: "A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732] comment: Some anaerobic or microaerophilic organisms (e.g. Entamoeba histolytica, Giardia intestinalis and several Microsporidia species) do not have mitochondria, and contain mitochondrion-related organelles (MROs) instead, called mitosomes or hydrogenosomes, very likely derived from mitochondria. To annotate gene products located in these mitochondrial relics in species such as Entamoeba histolytica, Giardia intestinalis or others, please use GO:0032047 'mitosome' or GO:0042566 'hydrogenosome'. (See PMID:24316280 for a list of species currently known to contain mitochondrion-related organelles.) subset: goslim_agr subset: goslim_candida subset: goslim_chembl subset: goslim_drosophila subset: goslim_euk_cellular_processes_ribbon subset: goslim_flybase_ribbon subset: goslim_generic subset: goslim_mouse subset: goslim_pir subset: goslim_plant subset: goslim_plant_ribbon subset: goslim_yeast synonym: "mitochondria" EXACT [] xref: NIF_Subcellular:sao1860313010 xref: Wikipedia:Mitochondrion is_a: GO:0043231 ! intracellular membrane-bounded organelle relationship: BFO:0000050 GO:0005737 ! part of cytoplasm relationship: RO:0002162 NCBITaxon:2759 ! in taxon Eukaryota [Term] id: GO:0005740 name: mitochondrial envelope namespace: cellular_component def: "The double lipid bilayer enclosing the mitochondrion and separating its contents from the cell cytoplasm; includes the intermembrane space." [GOC:ai, GOC:pz] subset: goslim_candida subset: goslim_yeast is_a: GO:0031967 ! organelle envelope relationship: BFO:0000050 GO:0005739 ! part of mitochondrion [Term] id: GO:0005741 name: mitochondrial outer membrane namespace: cellular_component def: "The outer, i.e. cytoplasm-facing, lipid bilayer of the mitochondrial envelope." [GOC:ai] synonym: "mitochondrion outer membrane" EXACT [] synonym: "outer mitochondrial membrane" EXACT [] synonym: "outer mitochondrion membrane" EXACT [] xref: NIF_Subcellular:sao1289741256 xref: Wikipedia:Outer_mitochondrial_membrane is_a: GO:0031966 ! mitochondrial membrane is_a: GO:0031968 ! organelle outer membrane intersection_of: GO:0016020 ! membrane intersection_of: RO:0002007 GO:0005739 ! bounding layer of mitochondrion relationship: RO:0002007 GO:0005739 ! bounding layer of mitochondrion [Term] id: GO:0005759 name: mitochondrial matrix namespace: cellular_component def: "The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation." [GOC:as, ISBN:0198506732] synonym: "mitochondrial lumen" EXACT [] synonym: "mitochondrial stroma" NARROW [] xref: NIF_Subcellular:sao1804523077 xref: Wikipedia:Mitochondrial_matrix is_a: GO:0070013 ! intracellular organelle lumen relationship: BFO:0000050 GO:0005739 ! part of mitochondrion [Term] id: GO:0005761 name: mitochondrial ribosome namespace: cellular_component def: "A ribosome found in the mitochondrion of a eukaryotic cell; contains a characteristic set of proteins distinct from those of cytosolic ribosomes." [GOC:mah, ISBN:0198506732] synonym: "55S ribosome, mitochondrial" NARROW [] is_a: GO:0000313 ! organellar ribosome intersection_of: GO:0005840 ! ribosome intersection_of: BFO:0000050 GO:0005759 ! part of mitochondrial matrix relationship: BFO:0000050 GO:0005759 ! part of mitochondrial matrix [Term] id: GO:0005764 name: lysosome namespace: cellular_component def: "A small lytic vacuole that has cell cycle-independent morphology found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions." [GOC:mah, ISBN:0198506732] subset: goslim_chembl subset: goslim_generic subset: goslim_plant xref: NIF_Subcellular:sao585356902 xref: Wikipedia:Lysosome is_a: GO:0000323 ! lytic vacuole property_value: RO:0002161 NCBITaxon:4751 [Term] id: GO:0005765 name: lysosomal membrane namespace: cellular_component def: "The lipid bilayer surrounding the lysosome and separating its contents from the cell cytoplasm." [GOC:ai] synonym: "lysosome membrane" EXACT [] is_a: GO:0098852 ! lytic vacuole membrane intersection_of: GO:0016020 ! membrane intersection_of: RO:0002007 GO:0005764 ! bounding layer of lysosome relationship: RO:0002007 GO:0005764 ! bounding layer of lysosome property_value: RO:0002161 NCBITaxon:4751 [Term] id: GO:0005766 name: primary lysosome namespace: cellular_component def: "A lysosome before it has fused with a vesicle or vacuole." [GOC:jl, ISBN:0815316194] xref: NIF_Subcellular:sao1140587416 is_a: GO:0005764 ! lysosome property_value: RO:0002161 NCBITaxon:4751 [Term] id: GO:0005773 name: vacuole namespace: cellular_component def: "A closed structure, found only in eukaryotic cells, that is completely surrounded by unit membrane and contains liquid material. Cells contain one or several vacuoles, that may have different functions from each other. Vacuoles have a diverse array of functions. They can act as a storage organelle for nutrients or waste products, as a degradative compartment, as a cost-effective way of increasing cell size, and as a homeostatic regulator controlling both turgor pressure and pH of the cytosol." [GOC:mtg_sensu, ISBN:0198506732] subset: goslim_agr subset: goslim_candida subset: goslim_chembl subset: goslim_drosophila subset: goslim_euk_cellular_processes_ribbon subset: goslim_flybase_ribbon subset: goslim_generic subset: goslim_mouse subset: goslim_pir subset: goslim_plant subset: goslim_plant_ribbon subset: goslim_yeast synonym: "vacuolar carboxypeptidase Y" RELATED [] xref: Wikipedia:Vacuole is_a: GO:0043231 ! intracellular membrane-bounded organelle relationship: BFO:0000050 GO:0005737 ! part of cytoplasm [Term] id: GO:0005774 name: vacuolar membrane namespace: cellular_component def: "The lipid bilayer surrounding the vacuole and separating its contents from the cytoplasm of the cell." [GOC:ai] is_a: GO:0098588 ! bounding membrane of organelle intersection_of: GO:0016020 ! membrane intersection_of: RO:0002007 GO:0005773 ! bounding layer of vacuole relationship: RO:0002007 GO:0005773 ! bounding layer of vacuole [Term] id: GO:0005775 name: vacuolar lumen namespace: cellular_component def: "The volume enclosed within the vacuolar membrane." [ISBN:0198506732] is_a: GO:0070013 ! intracellular organelle lumen intersection_of: GO:0031974 ! membrane-enclosed lumen intersection_of: BFO:0000050 GO:0005773 ! part of vacuole relationship: BFO:0000050 GO:0005773 ! part of vacuole [Term] id: GO:0005794 name: Golgi apparatus namespace: cellular_component def: "A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways." [ISBN:0198506732, PMID:9695800] comment: Note that the Golgi apparatus can be located in various places in the cytoplasm. In plants and lower animal cells, the Golgi apparatus exists as many copies of discrete stacks dispersed throughout the cytoplasm, while the Golgi apparatus of interphase mammalian cells is a juxtanuclear, often pericentriolar reticulum, where the discrete Golgi stacks are stitched together to form a compact and interconnected ribbon, sometimes called the Golgi ribbon. subset: goslim_agr subset: goslim_candida subset: goslim_chembl subset: goslim_drosophila subset: goslim_euk_cellular_processes_ribbon subset: goslim_generic subset: goslim_mouse subset: goslim_pir subset: goslim_plant subset: goslim_plant_ribbon subset: goslim_yeast synonym: "Golgi" BROAD [] synonym: "Golgi complex" EXACT [] synonym: "Golgi ribbon" NARROW [] xref: NIF_Subcellular:sao451912436 xref: Wikipedia:Golgi_apparatus is_a: GO:0043231 ! intracellular membrane-bounded organelle relationship: BFO:0000050 GO:0005737 ! part of cytoplasm relationship: BFO:0000050 GO:0012505 ! part of endomembrane system relationship: RO:0002162 NCBITaxon:2759 ! in taxon Eukaryota property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/14798" xsd:anyURI [Term] id: GO:0005798 name: Golgi-associated vesicle namespace: cellular_component def: "Any vesicle associated with the Golgi complex and involved in mediating transport within the Golgi or between the Golgi and other parts of the cell." [GOC:mah] comment: Note that this definition includes vesicles that are transiently associated with the Golgi. synonym: "Golgi vesicle" RELATED [] synonym: "vesicular component" RELATED [NIF_Subcellular:sao138219748] xref: NIF_Subcellular:sao819927218 is_a: GO:0031410 ! cytoplasmic vesicle [Term] id: GO:0005814 name: centriole namespace: cellular_component def: "A cellular organelle, found close to the nucleus in many eukaryotic cells, consisting of a small cylinder with microtubular walls, 300-500 nm long and 150-250 nm in diameter. It contains nine short, parallel, peripheral microtubular fibrils, each fibril consisting of one complete microtubule fused to two incomplete microtubules. Cells usually have two centrioles, lying at right angles to each other. At division, each pair of centrioles generates another pair and the twin pairs form the pole of the mitotic spindle." [ISBN:0198547684] comment: In most eukaryotic cells, 'ciliary basal body' (GO:0036064) and 'centriole' (GO:0005814) represent a common entity that cycles through its function in cell division, then ciliogenesis, then cell division again. However, these structures are modified extensively as they transition into each other, and may contain different proteins, specific to each component. synonym: "daughter centriole" NARROW [GOC:cilia] synonym: "mother centriole" NARROW [GOC:cilia] xref: NIF_Subcellular:sao95019936 xref: Wikipedia:Centriole is_a: GO:0043232 ! intracellular membraneless organelle relationship: BFO:0000050 GO:0005815 ! part of microtubule organizing center [Term] id: GO:0005815 name: microtubule organizing center namespace: cellular_component def: "An intracellular structure that can catalyze gamma-tubulin-dependent microtubule nucleation and that can anchor microtubules by interacting with their minus ends, plus ends or sides." [GOC:vw, ISBN:0815316194, PMID:17072892, PMID:17245416, Wikipedia:Microtubule_organizing_center] subset: goslim_candida subset: goslim_chembl subset: goslim_euk_cellular_processes_ribbon subset: goslim_generic subset: goslim_yeast synonym: "microtubule organising centre" EXACT [] synonym: "MTOC" EXACT [] xref: Wikipedia:Microtubule_organizing_center is_a: GO:0110165 ! cellular anatomical structure relationship: BFO:0000050 GO:0015630 ! part of microtubule cytoskeleton [Term] id: GO:0005829 name: cytosol namespace: cellular_component def: "The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl] subset: goslim_agr subset: goslim_chembl subset: goslim_drosophila subset: goslim_euk_cellular_processes_ribbon subset: goslim_flybase_ribbon subset: goslim_generic subset: goslim_mouse subset: goslim_plant xref: NIF_Subcellular:sao101633890 xref: Wikipedia:Cytosol is_a: GO:0110165 ! cellular anatomical structure relationship: BFO:0000050 GO:0005737 ! part of cytoplasm [Term] id: GO:0005840 name: ribosome namespace: cellular_component def: "An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732] subset: goslim_candida subset: goslim_chembl subset: goslim_euk_cellular_processes_ribbon subset: goslim_generic subset: goslim_metagenomics subset: goslim_pir subset: goslim_plant subset: goslim_plant_ribbon subset: goslim_prokaryote subset: goslim_prokaryote_ribbon subset: goslim_yeast synonym: "free ribosome" NARROW [NIF_Subcellular:sao1139385046] synonym: "membrane bound ribosome" NARROW [NIF_Subcellular:sao1291545653] synonym: "ribosomal RNA" RELATED [] xref: NIF_Subcellular:sao1429207766 xref: Wikipedia:Ribosome is_a: GO:0043232 ! intracellular membraneless organelle relationship: BFO:0000051 CHEBI:33697 ! has part relationship: BFO:0000051 PR:000000001 ! has part protein relationship: RO:0002216 GO:0006412 ! capable of part of translation property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/17777" xsd:anyURI property_value: skos:prefLabel "ribosome" xsd:string [Term] id: GO:0005856 name: cytoskeleton namespace: cellular_component def: "A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, PMID:16959967, PMID:27419875] subset: goslim_agr subset: goslim_candida subset: goslim_chembl subset: goslim_drosophila subset: goslim_euk_cellular_processes_ribbon subset: goslim_flybase_ribbon subset: goslim_generic subset: goslim_mouse subset: goslim_pir subset: goslim_plant subset: goslim_plant_ribbon subset: goslim_prokaryote subset: goslim_yeast xref: Wikipedia:Cytoskeleton is_a: GO:0043232 ! intracellular membraneless organelle [Term] id: GO:0005858 name: axonemal dynein complex namespace: cellular_component def: "A dynein complex found in eukaryotic cilia and flagella; the motor domain heads interact with adjacent microtubules to generate a sliding force which is converted to a bending motion." [GOC:cilia, GOC:hla, GOC:krc, ISBN:0815316194] synonym: "axonemal dynein heavy chain" NARROW [] synonym: "axonemal dynein intermediate chain" NARROW [] synonym: "axonemal dynein intermediate light chain" NARROW [] synonym: "axonemal dynein light chain" NARROW [] is_a: GO:0030286 ! dynein complex intersection_of: GO:0030286 ! dynein complex intersection_of: BFO:0000050 GO:0005930 ! part of axoneme relationship: BFO:0000050 GO:0005930 ! part of axoneme property_value: RO:0002161 NCBITaxon:3176 property_value: RO:0002161 NCBITaxon:3378 property_value: RO:0002161 NCBITaxon:3398 property_value: RO:0002161 NCBITaxon:4890 property_value: RO:0002161 NCBITaxon:5782 [Term] id: GO:0005874 name: microtubule namespace: cellular_component def: "Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle." [ISBN:0879693568] subset: goslim_metagenomics synonym: "microtubuli" EXACT [] synonym: "microtubulus" EXACT [] synonym: "neurotubule" NARROW [NIF_Subcellular:sao248349196] xref: NIF_Subcellular:sao1846835077 xref: Wikipedia:Microtubule is_a: GO:0099513 ! polymeric cytoskeletal fiber relationship: BFO:0000050 GO:0015630 ! part of microtubule cytoskeleton [Term] id: GO:0005875 name: microtubule associated complex namespace: cellular_component def: "Any multimeric complex connected to a microtubule." [GOC:jl] is_a: BFO:0000004 is_a: GO:0032991 ! protein-containing complex relationship: BFO:0000050 GO:0015630 ! part of microtubule cytoskeleton [Term] id: GO:0005879 name: axonemal microtubule namespace: cellular_component def: "A microtubule in the axoneme of a eukaryotic cilium or flagellum; an axoneme contains nine modified doublet microtubules, which may or may not surround a pair of single microtubules." [GOC:cilia, ISBN:0815316194] is_a: GO:0005881 ! cytoplasmic microtubule intersection_of: GO:0005874 ! microtubule intersection_of: BFO:0000050 GO:0005930 ! part of axoneme relationship: BFO:0000050 GO:0005930 ! part of axoneme property_value: RO:0002161 NCBITaxon:3176 property_value: RO:0002161 NCBITaxon:3378 property_value: RO:0002161 NCBITaxon:3398 property_value: RO:0002161 NCBITaxon:4890 property_value: RO:0002161 NCBITaxon:5782 [Term] id: GO:0005880 name: nuclear microtubule namespace: cellular_component def: "Any microtubule in the nucleus of a cell." [GOC:mah] is_a: GO:0005874 ! microtubule intersection_of: GO:0005874 ! microtubule intersection_of: BFO:0000050 GO:0005634 ! part of nucleus relationship: BFO:0000050 GO:0005634 ! part of nucleus [Term] id: GO:0005881 name: cytoplasmic microtubule namespace: cellular_component def: "Any microtubule in the cytoplasm of a cell." [GOC:mah] synonym: "non-spindle-associated astral microtubule" NARROW [] is_a: GO:0005874 ! microtubule intersection_of: GO:0005874 ! microtubule intersection_of: BFO:0000050 GO:0005737 ! part of cytoplasm relationship: BFO:0000050 GO:0005737 ! part of cytoplasm [Term] id: GO:0005882 name: intermediate filament namespace: cellular_component def: "A cytoskeletal structure that forms a distinct elongated structure, characteristically 10 nm in diameter, that occurs in the cytoplasm of eukaryotic cells. Intermediate filaments form a fibrous system, composed of chemically heterogeneous subunits and involved in mechanically integrating the various components of the cytoplasmic space. Intermediate filaments may be divided into five chemically distinct classes: Type I, acidic keratins; Type II, basic keratins; Type III, including desmin, vimentin and others; Type IV, neurofilaments and related filaments; and Type V, lamins." [ISBN:0198506732, PMID:17493611, PMID:17551517, PMID:7979242] synonym: "intermediate filament associated protein" RELATED [] synonym: "type I intermediate filament associated protein" RELATED [] synonym: "type II intermediate filament associated protein" RELATED [] xref: FMA:63851 xref: NIF_Subcellular:sao952483289 xref: Wikipedia:Intermediate_filament is_a: GO:0099513 ! polymeric cytoskeletal fiber relationship: BFO:0000050 GO:0045111 ! part of intermediate filament cytoskeleton [Term] id: GO:0005884 name: actin filament namespace: cellular_component def: "A filamentous structure formed of a two-stranded helical polymer of the protein actin and associated proteins. Actin filaments are a major component of the contractile apparatus of skeletal muscle and the microfilaments of the cytoskeleton of eukaryotic cells. The filaments, comprising polymerized globular actin molecules, appear as flexible structures with a diameter of 5-9 nm. They are organized into a variety of linear bundles, two-dimensional networks, and three dimensional gels. In the cytoskeleton they are most highly concentrated in the cortex of the cell just beneath the plasma membrane." [GOC:mah, ISBN:0198506732, PMID:10666339] synonym: "microfilament" EXACT [] xref: FMA:63850 xref: NIF_Subcellular:sao1588493326 xref: Wikipedia:Actin is_a: GO:0099513 ! polymeric cytoskeletal fiber relationship: BFO:0000050 GO:0015629 ! part of actin cytoskeleton [Term] id: GO:0005886 name: plasma membrane namespace: cellular_component def: "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363] subset: goslim_agr subset: goslim_candida subset: goslim_chembl subset: goslim_drosophila subset: goslim_euk_cellular_processes_ribbon subset: goslim_generic subset: goslim_metagenomics subset: goslim_mouse subset: goslim_plant subset: goslim_plant_ribbon subset: goslim_prokaryote subset: goslim_prokaryote_ribbon subset: goslim_yeast synonym: "bacterial inner membrane" NARROW [] synonym: "cell membrane" EXACT [] synonym: "cellular membrane" EXACT [NIF_Subcellular:sao6433132645] synonym: "cytoplasmic membrane" EXACT [] synonym: "inner endospore membrane" NARROW [] synonym: "integral component of plasma membrane" NARROW [] synonym: "integral to plasma membrane" NARROW [] synonym: "juxtamembrane" BROAD [] synonym: "plasma membrane lipid bilayer" NARROW [GOC:mah] synonym: "plasmalemma" EXACT [] xref: NIF_Subcellular:sao1663586795 xref: Wikipedia:Cell_membrane is_a: GO:0016020 ! membrane relationship: BFO:0000050 GO:0071944 ! part of cell periphery property_value: skos:prefLabel "plasma membrane" xsd:string [Term] id: GO:0005891 name: voltage-gated calcium channel complex namespace: cellular_component def: "A protein complex that forms a transmembrane channel through which calcium ions may pass in response to changes in membrane potential." [GOC:mah] subset: goslim_pir synonym: "voltage gated calcium channel complex" EXACT [] synonym: "voltage-dependent calcium channel complex" EXACT [] synonym: "voltage-sensitive calcium channel complex" EXACT [] is_a: GO:0034704 ! calcium channel complex is_a: GO:0098797 ! plasma membrane protein complex intersection_of: GO:0032991 ! protein-containing complex intersection_of: RO:0002215 GO:0005245 ! capable of voltage-gated calcium channel activity relationship: RO:0002215 GO:0005245 ! capable of voltage-gated calcium channel activity [Term] id: GO:0005899 name: insulin receptor complex namespace: cellular_component def: "A disulfide-bonded, heterotetrameric receptor complex. The alpha chains are entirely extracellular, while each beta chain has one transmembrane domain. The ligand binds to the alpha subunit extracellular domain and the kinase is associated with the beta subunit intracellular domain." [ISBN:0198506732] is_a: GO:0098802 ! plasma membrane signaling receptor complex is_a: GO:1902911 ! protein kinase complex intersection_of: GO:0032991 ! protein-containing complex intersection_of: RO:0002215 GO:0005009 ! capable of insulin receptor activity relationship: RO:0002215 GO:0005009 ! capable of insulin receptor activity [Term] id: GO:0005902 name: microvillus namespace: cellular_component def: "Thin cylindrical membrane-covered projections on the surface of an animal cell containing a core bundle of actin filaments. Present in especially large numbers on the absorptive surface of intestinal cells." [ISBN:0815316194] comment: Note that this term refers to a projection from a single cell, and should not be confused with 'microvillus' as used to refer to a multicellular structure such as that found in the placenta. subset: goslim_pir synonym: "microvilli" RELATED [NIF_Subcellular:sao671419673] xref: NIF_Subcellular:sao671419673 xref: Wikipedia:Microvillus is_a: GO:0098858 ! actin-based cell projection relationship: BFO:0000050 CL:0000066 ! part of epithelial cell relationship: BFO:0000051 GO:0032432 ! has part actin filament bundle [Term] id: GO:0005903 name: brush border namespace: cellular_component def: "The dense covering of microvilli on the apical surface of an epithelial cell in tissues such as the intestine, kidney, and choroid plexus; the microvilli aid absorption by increasing the surface area of the cell." [GOC:sl, ISBN:0815316194] subset: goslim_pir xref: Wikipedia:Brush_border is_a: GO:0098862 ! cluster of actin-based cell projections relationship: BFO:0000050 CL:0000066 ! part of epithelial cell relationship: BFO:0000050 GO:0045177 ! part of apical part of cell relationship: BFO:0000051 GO:0005902 ! has part microvillus property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/29939" xsd:anyURI [Term] id: GO:0005911 name: cell-cell junction namespace: cellular_component def: "A cell junction that forms a connection between two or more cells of an organism; excludes direct cytoplasmic intercellular bridges, such as ring canals in insects." [GOC:aruk, GOC:bc, GOC:dgh, GOC:hb, GOC:mah, PMID:21422226, PMID:28096264] synonym: "cell-cell contact region" BROAD [] synonym: "cell-cell contact zone" BROAD [] synonym: "intercellular junction" EXACT [NIF_Subcellular:sao1395777368] xref: NIF_Subcellular:sao1922892319 is_a: GO:0070161 ! anchoring junction property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/22122" xsd:anyURI property_value: RO:0002161 NCBITaxon:4751 property_value: skos:prefLabel "cell-cell junction" xsd:string [Term] id: GO:0005923 name: bicellular tight junction namespace: cellular_component def: "An occluding cell-cell junction that is composed of a branching network of sealing strands that completely encircles the apical end of each cell in an epithelial sheet; the outer leaflets of the two interacting plasma membranes are seen to be tightly apposed where sealing strands are present. Each sealing strand is composed of a long row of transmembrane adhesion proteins embedded in each of the two interacting plasma membranes." [GOC:mah, ISBN:0815332181] synonym: "zonula occludens" EXACT [] xref: NIF_Subcellular:sao1939999134 xref: Wikipedia:Tight_junction is_a: GO:0070160 ! tight junction relationship: BFO:0000050 GO:0043296 ! part of apical junction complex property_value: RO:0002161 NCBITaxon:4751 [Term] id: GO:0005927 name: muscle tendon junction namespace: cellular_component def: "A cell-substrate junction found at the terminal anchorage site of skeletal muscle cells to tendons." [GOC:mtg_muscle, PMID:12842007] synonym: "myotendinous junction" EXACT [] is_a: GO:0030055 ! cell-substrate junction property_value: RO:0002161 NCBITaxon:4751 [Term] id: GO:0005929 name: cilium namespace: cellular_component def: "A specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface and of some cytoplasmic parts. Each cilium is largely bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored to a basal body." [GOC:cilia, GOC:curators, GOC:kmv, GOC:vw, ISBN:0198547684, PMID:16824949, PMID:17009929, PMID:20144998] comment: Note that we deem cilium and microtubule-based flagellum to be equivalent. In most eukaryotic species, intracellular sub-components of the cilium, such as the ciliary base and rootlet, are located near the plasma membrane. In Diplomonads such as Giardia, instead, the same ciliary parts are located further intracellularly. Also, 'cilium' may be used when axonemal structure and/or motility are unknown, or when axonemal structure is unusual. For all other cases, please refer to children of 'cilium'. Finally, note that any role of ciliary proteins in sensory events should be captured by annotating to relevant biological process terms. subset: goslim_chembl subset: goslim_drosophila subset: goslim_generic subset: goslim_pir synonym: "eukaryotic flagellum" EXACT [] synonym: "flagellum" RELATED [] synonym: "microtubule-based flagellum" EXACT [] synonym: "primary cilium" NARROW [] xref: FMA:67181 xref: NIF_Subcellular:sao787716553 xref: Wikipedia:Cilium is_a: GO:0043227 ! membrane-bounded organelle is_a: GO:0120025 ! plasma membrane bounded cell projection relationship: BFO:0000051 GO:0030990 ! has part intraciliary transport particle relationship: RO:0002162 NCBITaxon:2759 ! in taxon Eukaryota property_value: RO:0002161 NCBITaxon:3176 property_value: RO:0002161 NCBITaxon:3378 property_value: RO:0002161 NCBITaxon:3398 property_value: RO:0002161 NCBITaxon:4890 property_value: RO:0002161 NCBITaxon:5782 property_value: skos:prefLabel "cilium" xsd:string [Term] id: GO:0005930 name: axoneme namespace: cellular_component def: "The bundle of microtubules and associated proteins that forms the core of cilia (also called flagella) in eukaryotic cells and is responsible for their movements." [GOC:bf, GOC:cilia, ISBN:0198547684] comment: Note that cilia and eukaryotic flagella are deemed to be equivalent. In diplomonad species, such as Giardia, the axoneme may extend intracellularly up to 5um away from the plane of the plasma membrane. subset: goslim_pir synonym: "ciliary axoneme" EXACT [] synonym: "cilium axoneme" EXACT [] synonym: "flagellar axoneme" EXACT [] synonym: "flagellum axoneme" EXACT [] xref: Wikipedia:Axoneme is_a: GO:0110165 ! cellular anatomical structure relationship: BFO:0000050 GO:0005856 ! part of cytoskeleton relationship: BFO:0000050 GO:0097014 ! part of ciliary plasm relationship: BFO:0000051 GO:0005874 ! has part microtubule property_value: RO:0002161 NCBITaxon:3176 property_value: RO:0002161 NCBITaxon:3378 property_value: RO:0002161 NCBITaxon:3398 property_value: RO:0002161 NCBITaxon:4890 property_value: RO:0002161 NCBITaxon:5782 [Term] id: GO:0005938 name: cell cortex namespace: cellular_component def: "The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins." [GOC:mah, ISBN:0815316194] subset: goslim_candida subset: goslim_yeast synonym: "cell periphery" RELATED [] synonym: "ectoplasm" NARROW [] synonym: "peripheral cytoplasm" RELATED [] xref: Wikipedia:Cell_cortex is_a: GO:0005737 ! cytoplasm intersection_of: GO:0005737 ! cytoplasm intersection_of: BFO:0000050 GO:0071944 ! part of cell periphery relationship: BFO:0000050 GO:0071944 ! part of cell periphery property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/26298" xsd:anyURI [Term] id: GO:0005975 name: carbohydrate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:mah, ISBN:0198506732] subset: goslim_agr subset: goslim_candida subset: goslim_chembl subset: goslim_drosophila subset: goslim_generic subset: goslim_metagenomics subset: goslim_pir subset: goslim_plant subset: goslim_plant_ribbon subset: goslim_pombe subset: goslim_prokaryote subset: goslim_yeast synonym: "carbohydrate metabolism" EXACT [] xref: Reactome:R-HSA-71387 "Metabolism of carbohydrates" xref: Wikipedia:Carbohydrate_metabolism is_a: BFO:0000003 is_a: GO:0044238 ! primary metabolic process intersection_of: GO:0008152 ! metabolic process intersection_of: RO:0004007 CHEBI:16646 ! has primary input or output relationship: RO:0004007 CHEBI:16646 ! has primary input or output property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/22880" xsd:anyURI creation_date: 2012-10-23T15:40:34Z [Term] id: GO:0005976 name: polysaccharide metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a polysaccharide, a polymer of many (typically more than 10) monosaccharide residues linked glycosidically." [ISBN:0198547684] subset: goslim_pir synonym: "glycan metabolic process" NARROW [] synonym: "glycan metabolism" NARROW [] synonym: "multicellular organismal polysaccharide metabolic process" NARROW [] synonym: "polysaccharide metabolism" EXACT [] is_a: GO:0005975 ! carbohydrate metabolic process is_a: GO:0043170 ! macromolecule metabolic process intersection_of: GO:0008152 ! metabolic process intersection_of: RO:0004007 CHEBI:18154 ! has primary input or output relationship: RO:0004007 CHEBI:18154 ! has primary input or output [Term] id: GO:0005977 name: glycogen metabolic process namespace: biological_process def: "The chemical reactions and pathways involving glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues in alpha-(1->4) glycosidic linkage, joined together by alpha-(1->6) glycosidic linkages." [ISBN:0198506732] synonym: "glycogen metabolism" EXACT [] xref: Reactome:R-HSA-8982491 "Glycogen metabolism" is_a: GO:0006112 ! energy reserve metabolic process is_a: GO:0044042 ! glucan metabolic process intersection_of: GO:0008152 ! metabolic process intersection_of: RO:0004007 CHEBI:28087 ! has primary input or output relationship: RO:0004007 CHEBI:28087 ! has primary input or output [Term] id: GO:0005978 name: glycogen biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues." [ISBN:0198506732] synonym: "glycogen anabolism" EXACT [] synonym: "glycogen biosynthesis" EXACT [] synonym: "glycogen formation" EXACT [] synonym: "glycogen synthesis" EXACT [] xref: MetaCyc:PWY-7900 {source="skos:narrowMatch"} xref: Reactome:R-HSA-3322077 "Glycogen synthesis" is_a: GO:0005977 ! glycogen metabolic process is_a: GO:0009250 ! glucan biosynthetic process intersection_of: GO:0009058 ! biosynthetic process intersection_of: RO:0004008 CHEBI:28087 ! has primary output relationship: RO:0004008 CHEBI:28087 ! has primary output property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/27107" xsd:anyURI property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/28527" xsd:anyURI property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/28968" xsd:anyURI [Term] id: GO:0005979 name: regulation of glycogen biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of glycogen." [GOC:go_curators] synonym: "regulation of glycogen anabolism" EXACT [] synonym: "regulation of glycogen biosynthesis" EXACT [] synonym: "regulation of glycogen formation" EXACT [] synonym: "regulation of glycogen synthesis" EXACT [] is_a: GO:0010962 ! regulation of glucan biosynthetic process is_a: GO:0070873 ! regulation of glycogen metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0005978 ! regulates glycogen biosynthetic process relationship: RO:0002211 GO:0005978 ! regulates glycogen biosynthetic process [Term] id: GO:0005980 name: glycogen catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues." [ISBN:0198506732] synonym: "glycogen breakdown" EXACT [] synonym: "glycogen catabolism" EXACT [] synonym: "glycogen degradation" EXACT [] synonym: "glycogenolysis" EXACT [GOC:sl] xref: MetaCyc:PWY-7662 {source="skos:narrowMatch"} xref: Reactome:R-HSA-70221 "Glycogen breakdown (glycogenolysis)" is_a: GO:0005977 ! glycogen metabolic process is_a: GO:0009251 ! glucan catabolic process intersection_of: GO:0009056 ! catabolic process intersection_of: RO:0004009 CHEBI:28087 ! has primary input relationship: RO:0004009 CHEBI:28087 ! has primary input property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/27107" xsd:anyURI property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/28527" xsd:anyURI [Term] id: GO:0005981 name: regulation of glycogen catabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of glycogen." [GOC:go_curators] synonym: "regulation of glycogen breakdown" EXACT [] synonym: "regulation of glycogen catabolism" EXACT [] synonym: "regulation of glycogen degradation" EXACT [] synonym: "regulation of glycogenolysis" EXACT [GOC:sl] is_a: GO:0043470 ! regulation of carbohydrate catabolic process is_a: GO:0070873 ! regulation of glycogen metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0005980 ! regulates glycogen catabolic process relationship: RO:0002211 GO:0005980 ! regulates glycogen catabolic process [Term] id: GO:0005982 name: starch metabolic process namespace: biological_process def: "The chemical reactions and pathways involving starch, the most important reserve polysaccharide in plants. It is a glucan consisting of two components, amylose and amylopectin, which are both glucose homopolymers. Starch is synthesized as a temporary storage form of carbon and can be catabolized to produce sucrose." [ISBN:0198506732] synonym: "starch metabolism" EXACT [] is_a: GO:0044042 ! glucan metabolic process intersection_of: GO:0008152 ! metabolic process intersection_of: RO:0004007 CHEBI:28017 ! has primary input or output relationship: RO:0004007 CHEBI:28017 ! has primary input or output [Term] id: GO:0005983 name: starch catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of starch, the most important reserve polysaccharide in plants." [GOC:ai] synonym: "starch breakdown" EXACT [] synonym: "starch catabolism" EXACT [] synonym: "starch degradation" EXACT [] xref: MetaCyc:PWY-842 is_a: GO:0005982 ! starch metabolic process is_a: GO:0009251 ! glucan catabolic process intersection_of: GO:0009056 ! catabolic process intersection_of: RO:0004009 CHEBI:28017 ! has primary input relationship: RO:0004009 CHEBI:28017 ! has primary input [Term] id: GO:0005996 name: monosaccharide metabolic process namespace: biological_process def: "The chemical reactions and pathways involving monosaccharides, the simplest carbohydrates. They are polyhydric alcohols containing either an aldehyde or a keto group and between three to ten or more carbon atoms. They form the constitutional repeating units of oligo- and polysaccharides." [ISBN:0198506732] synonym: "monosaccharide metabolism" EXACT [] is_a: GO:0005975 ! carbohydrate metabolic process is_a: GO:0044281 ! small molecule metabolic process intersection_of: GO:0008152 ! metabolic process intersection_of: RO:0004007 CHEBI:35381 ! has primary input or output relationship: RO:0004007 CHEBI:35381 ! has primary input or output [Term] id: GO:0006006 name: glucose metabolic process namespace: biological_process def: "The chemical reactions and pathways involving glucose, the aldohexose gluco-hexose. D-glucose is dextrorotatory and is sometimes known as dextrose; it is an important source of energy for living organisms and is found free as well as combined in homo- and hetero-oligosaccharides and polysaccharides." [ISBN:0198506732] synonym: "cellular glucose metabolic process" EXACT [GOC:vw] synonym: "glucose metabolism" EXACT [] xref: Reactome:R-HSA-70326 "Glucose metabolism" is_a: GO:0019318 ! hexose metabolic process intersection_of: GO:0008152 ! metabolic process intersection_of: RO:0004007 CHEBI:4167 ! has primary input or output relationship: RO:0004007 CHEBI:4167 ! has primary input or output [Term] id: GO:0006007 name: glucose catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of glucose, the aldohexose gluco-hexose." [GOC:ai] synonym: "glucose breakdown" EXACT [] synonym: "glucose catabolism" EXACT [] synonym: "glucose degradation" EXACT [] is_a: GO:0006006 ! glucose metabolic process is_a: GO:0019320 ! hexose catabolic process intersection_of: GO:0009056 ! catabolic process intersection_of: RO:0004009 CHEBI:4167 ! has primary input relationship: RO:0004009 CHEBI:4167 ! has primary input [Term] id: GO:0006022 name: aminoglycan metabolic process namespace: biological_process def: "The chemical reactions and pathways involving aminoglycans, any polymer containing amino groups that consists of more than about 10 monosaccharide residues joined to each other by glycosidic linkages." [GOC:ai, ISBN:0198506732] synonym: "aminoglycan metabolism" EXACT [] is_a: GO:0043170 ! macromolecule metabolic process is_a: GO:1901135 ! carbohydrate derivative metabolic process intersection_of: GO:0008152 ! metabolic process intersection_of: RO:0004007 CHEBI:22506 ! has primary input or output relationship: RO:0004007 CHEBI:22506 ! has primary input or output [Term] id: GO:0006023 name: aminoglycan biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of aminoglycans, any polymer containing amino groups that consists of more than about 10 monosaccharide residues joined to each other by glycosidic linkages." [GOC:ai, ISBN:0198506732] synonym: "aminoglycan anabolism" EXACT [] synonym: "aminoglycan biosynthesis" EXACT [] synonym: "aminoglycan formation" EXACT [] synonym: "aminoglycan synthesis" EXACT [] is_a: GO:0006022 ! aminoglycan metabolic process is_a: GO:0009059 ! macromolecule biosynthetic process is_a: GO:1901137 ! carbohydrate derivative biosynthetic process intersection_of: GO:0009058 ! biosynthetic process intersection_of: RO:0004008 CHEBI:22506 ! has primary output relationship: RO:0004008 CHEBI:22506 ! has primary output [Term] id: GO:0006024 name: glycosaminoglycan biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of glycosaminoglycans, any one of a group of linear polysaccharides composed of repeating disaccharide units." [PMID:38500384] synonym: "glycosaminoglycan anabolism" EXACT [] synonym: "glycosaminoglycan biosynthesis" EXACT [] synonym: "glycosaminoglycan formation" EXACT [] synonym: "glycosaminoglycan synthesis" EXACT [] is_a: GO:0006023 ! aminoglycan biosynthetic process is_a: GO:0030203 ! glycosaminoglycan metabolic process intersection_of: GO:0009058 ! biosynthetic process intersection_of: RO:0004008 CHEBI:18085 ! has primary output relationship: RO:0004008 CHEBI:18085 ! has primary output property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/29745" xsd:anyURI [Term] id: GO:0006026 name: aminoglycan catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of aminoglycans, any polymer containing amino groups that consists of more than about 10 monosaccharide residues joined to each other by glycosidic linkages." [GOC:ai, ISBN:0198506732] synonym: "aminoglycan breakdown" EXACT [] synonym: "aminoglycan catabolism" EXACT [] synonym: "aminoglycan degradation" EXACT [] is_a: GO:0006022 ! aminoglycan metabolic process is_a: GO:0009057 ! macromolecule catabolic process is_a: GO:1901136 ! carbohydrate derivative catabolic process intersection_of: GO:0009056 ! catabolic process intersection_of: RO:0004009 CHEBI:22506 ! has primary input relationship: RO:0004009 CHEBI:22506 ! has primary input [Term] id: GO:0006027 name: glycosaminoglycan catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of glycosaminoglycans, any one of a group of linear polysaccharides composed of repeating disaccharide units." [PMID:38500384] synonym: "glycosaminoglycan breakdown" EXACT [] synonym: "glycosaminoglycan catabolism" EXACT [] synonym: "glycosaminoglycan degradation" EXACT [] xref: Reactome:R-HSA-2024101 "CS/DS degradation" is_a: GO:0006026 ! aminoglycan catabolic process is_a: GO:0030203 ! glycosaminoglycan metabolic process intersection_of: GO:0009056 ! catabolic process intersection_of: RO:0004009 CHEBI:18085 ! has primary input relationship: RO:0004009 CHEBI:18085 ! has primary input property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/29745" xsd:anyURI [Term] id: GO:0006029 name: proteoglycan metabolic process namespace: biological_process def: "The chemical reactions and pathways involving proteoglycans, any glycoprotein in which the carbohydrate units are glycosaminoglycans." [PMID:35536939] synonym: "proteoglycan metabolism" EXACT [] synonym: "proteoglycan sulfate transfer" NARROW [] is_a: GO:0009100 ! glycoprotein metabolic process intersection_of: GO:0008152 ! metabolic process intersection_of: RO:0004007 CHEBI:37396 ! has primary input or output relationship: RO:0004007 CHEBI:37396 ! has primary input or output property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/29745" xsd:anyURI [Term] id: GO:0006066 name: alcohol metabolic process namespace: biological_process def: "The chemical reactions and pathways involving alcohols, any of a class of compounds containing one or more hydroxyl groups attached to a saturated carbon atom." [ISBN:0198506732] subset: goslim_drosophila subset: goslim_pir synonym: "alcohol metabolism" EXACT [] is_a: BFO:0000003 is_a: GO:0044281 ! small molecule metabolic process intersection_of: GO:0008152 ! metabolic process intersection_of: RO:0004007 CHEBI:30879 ! has primary input or output relationship: RO:0004007 CHEBI:30879 ! has primary input or output [Term] id: GO:0006081 name: aldehyde metabolic process namespace: biological_process def: "The chemical reactions and pathways involving aldehydes, any organic compound with the formula R-CH=O, as carried out by individual cells." [GOC:go_curators, ISBN:0198506732] subset: goslim_pir synonym: "aldehyde metabolism" EXACT [] synonym: "alkanal metabolic process" EXACT [] synonym: "alkanal metabolism" EXACT [] is_a: BFO:0000003 is_a: GO:0008152 ! metabolic process intersection_of: GO:0008152 ! metabolic process intersection_of: RO:0004007 CHEBI:17478 ! has primary input or output relationship: RO:0004007 CHEBI:17478 ! has primary input or output property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/28908" xsd:anyURI [Term] id: GO:0006082 name: organic acid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving organic acids, any acidic compound containing carbon in covalent linkage." [ISBN:0198506732] subset: goslim_pir synonym: "organic acid metabolism" EXACT [] is_a: BFO:0000003 is_a: GO:0044281 ! small molecule metabolic process intersection_of: GO:0008152 ! metabolic process intersection_of: RO:0004007 CHEBI:64709 ! has primary input or output relationship: RO:0004007 CHEBI:64709 ! has primary input or output [Term] id: GO:0006091 name: generation of precursor metabolites and energy namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of precursor metabolites, substances from which energy is derived, and any process involved in the liberation of energy from these substances." [GOC:jl] subset: goslim_candida subset: goslim_chembl subset: goslim_drosophila subset: goslim_euk_cellular_processes_ribbon subset: goslim_generic subset: goslim_metagenomics subset: goslim_pir subset: goslim_plant subset: goslim_plant_ribbon subset: goslim_pombe subset: goslim_prokaryote subset: goslim_prokaryote_ribbon subset: goslim_yeast synonym: "energy pathways" BROAD [] synonym: "intermediary metabolism" RELATED [GOC:mah] synonym: "metabolic energy generation" RELATED [] is_a: GO:0008152 ! metabolic process [Term] id: GO:0006094 name: gluconeogenesis namespace: biological_process def: "The formation of glucose from noncarbohydrate precursors, such as pyruvate, amino acids and glycerol." [MetaCyc:GLUCONEO-PWY] synonym: "glucose biosynthesis" EXACT [] synonym: "glucose biosynthetic process" EXACT [] xref: MetaCyc:GLUCONEO-PWY {source="skos:narrowMatch"} xref: MetaCyc:PWY-6142 {source="skos:narrowMatch"} xref: MetaCyc:PWY66-399 {source="skos:narrowMatch"} xref: Reactome:R-HSA-70263 "Gluconeogenesis" xref: Wikipedia:Gluconeogenesis is_a: GO:0006006 ! glucose metabolic process is_a: GO:0019319 ! hexose biosynthetic process intersection_of: GO:0009058 ! biosynthetic process intersection_of: RO:0004008 CHEBI:4167 ! has primary output relationship: RO:0004008 CHEBI:4167 ! has primary output property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/28953" xsd:anyURI [Term] id: GO:0006109 name: regulation of carbohydrate metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving carbohydrates." [GOC:go_curators] synonym: "regulation of carbohydrate metabolism" EXACT [] is_a: GO:0080090 ! regulation of primary metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0005975 ! regulates carbohydrate metabolic process relationship: RO:0002211 GO:0005975 ! regulates carbohydrate metabolic process [Term] id: GO:0006111 name: regulation of gluconeogenesis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of gluconeogenesis, the formation of glucose from noncarbohydrate precursors, such as pyruvate, amino acids and glycerol." [GOC:go_curators] synonym: "regulation of gluconeogenesis involved in cellular glucose homeostasis" RELATED [] synonym: "regulation of glucose biosynthesis" BROAD [] synonym: "regulation of glucose biosynthetic process" BROAD [] is_a: GO:0010906 ! regulation of glucose metabolic process is_a: GO:0043255 ! regulation of carbohydrate biosynthetic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0006094 ! regulates gluconeogenesis relationship: RO:0002211 GO:0006094 ! regulates gluconeogenesis creation_date: 2013-01-18T12:47:43Z [Term] id: GO:0006112 name: energy reserve metabolic process namespace: biological_process def: "The chemical reactions and pathways by which a cell derives energy from stored compounds such as fats or glycogen." [GOC:mah] subset: goslim_pir synonym: "energy reserve metabolism" EXACT [] is_a: GO:0015980 ! energy derivation by oxidation of organic compounds [Term] id: GO:0006139 name: nucleobase-containing compound metabolic process namespace: biological_process def: "Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:ai] subset: goslim_pir subset: goslim_plant synonym: "cellular nucleobase, nucleoside, nucleotide and nucleic acid metabolic process" EXACT [] synonym: "cellular nucleobase, nucleoside, nucleotide and nucleic acid metabolism" EXACT [] synonym: "nucleobase, nucleoside and nucleotide metabolic process" RELATED [] synonym: "nucleobase, nucleoside, nucleotide and nucleic acid metabolic process" RELATED [GOC:dph, GOC:tb] synonym: "nucleobase, nucleoside, nucleotide and nucleic acid metabolism" EXACT [] is_a: BFO:0000003 is_a: GO:0044238 ! primary metabolic process intersection_of: GO:0008152 ! metabolic process intersection_of: RO:0004007 CHEBI:61120 ! has primary input or output relationship: RO:0004007 CHEBI:61120 ! has primary input or output [Term] id: GO:0006140 name: regulation of nucleotide metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving nucleotides." [GOC:go_curators] synonym: "regulation of nucleotide metabolism" EXACT [] is_a: GO:0019219 ! regulation of nucleobase-containing compound metabolic process is_a: GO:0051174 ! regulation of phosphorus metabolic process is_a: GO:0062012 ! regulation of small molecule metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0009117 ! regulates nucleotide metabolic process relationship: RO:0002211 GO:0009117 ! regulates nucleotide metabolic process [Term] id: GO:0006163 name: purine nucleotide metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a purine nucleotide, a compound consisting of nucleoside (a purine base linked to a deoxyribose or ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732] synonym: "purine metabolic process" NARROW [] synonym: "purine metabolism" NARROW [] synonym: "purine nucleotide metabolism" EXACT [] is_a: GO:0009117 ! nucleotide metabolic process is_a: GO:0072521 ! purine-containing compound metabolic process intersection_of: GO:0008152 ! metabolic process intersection_of: RO:0004007 CHEBI:26395 ! has primary input or output relationship: RO:0004007 CHEBI:26395 ! has primary input or output [Term] id: GO:0006164 name: purine nucleotide biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a purine nucleotide, a compound consisting of nucleoside (a purine base linked to a deoxyribose or ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732] synonym: "purine nucleotide anabolism" EXACT [] synonym: "purine nucleotide biosynthesis" EXACT [] synonym: "purine nucleotide formation" EXACT [] synonym: "purine nucleotide synthesis" EXACT [] xref: MetaCyc:DENOVOPURINE2-PWY is_a: GO:0006163 ! purine nucleotide metabolic process is_a: GO:0009165 ! nucleotide biosynthetic process is_a: GO:0072522 ! purine-containing compound biosynthetic process intersection_of: GO:0009058 ! biosynthetic process intersection_of: RO:0004008 CHEBI:26395 ! has primary output relationship: RO:0004008 CHEBI:26395 ! has primary output [Term] id: GO:0006172 name: ADP biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of ADP, adenosine 5'-diphosphate." [GOC:ai] synonym: "ADP anabolism" EXACT [] synonym: "ADP biosynthesis" EXACT [] synonym: "ADP formation" EXACT [] synonym: "ADP synthesis" EXACT [] is_a: GO:0009152 ! purine ribonucleotide biosynthetic process is_a: GO:0009180 ! purine ribonucleoside diphosphate biosynthetic process is_a: GO:0046031 ! ADP metabolic process intersection_of: GO:0009058 ! biosynthetic process intersection_of: RO:0004008 CHEBI:456216 ! has primary output relationship: RO:0004008 CHEBI:456216 ! has primary output [Term] id: GO:0006195 name: purine nucleotide catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of a purine nucleotide, a compound consisting of nucleoside (a purine base linked to a deoxyribose or ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732] synonym: "purine nucleotide breakdown" EXACT [] synonym: "purine nucleotide catabolism" EXACT [] synonym: "purine nucleotide degradation" EXACT [] xref: Reactome:R-HSA-74259 "Purine catabolism" is_a: GO:0006163 ! purine nucleotide metabolic process is_a: GO:0009166 ! nucleotide catabolic process is_a: GO:0072523 ! purine-containing compound catabolic process intersection_of: GO:0009056 ! catabolic process intersection_of: RO:0004009 CHEBI:26395 ! has primary input relationship: RO:0004009 CHEBI:26395 ! has primary input [Term] id: GO:0006259 name: DNA metabolic process namespace: biological_process def: "Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides." [ISBN:0198506732] subset: goslim_agr subset: goslim_candida subset: goslim_chembl subset: goslim_flybase_ribbon subset: goslim_metagenomics subset: goslim_pir subset: goslim_plant subset: goslim_plant_ribbon subset: goslim_prokaryote_ribbon synonym: "cellular DNA metabolism" EXACT [] synonym: "DNA metabolism" EXACT [] is_a: GO:0090304 ! nucleic acid metabolic process intersection_of: GO:0008152 ! metabolic process intersection_of: RO:0004007 CHEBI:16991 ! has primary input or output relationship: RO:0004007 CHEBI:16991 ! has primary input or output [Term] id: GO:0006308 name: DNA catabolic process namespace: biological_process def: "The cellular DNA metabolic process resulting in the breakdown of DNA, deoxyribonucleic acid, one of the two main types of nucleic acid, consisting of a long unbranched macromolecule formed from one or two strands of linked deoxyribonucleotides, the 3'-phosphate group of each constituent deoxyribonucleotide being joined in 3',5'-phosphodiester linkage to the 5'-hydroxyl group of the deoxyribose moiety of the next one." [GOC:go_curators, ISBN:0198506732] synonym: "DNA breakdown" EXACT [] synonym: "DNA catabolism" EXACT [] synonym: "DNA degradation" EXACT [] is_a: GO:0006259 ! DNA metabolic process is_a: GO:0141188 ! nucleic acid catabolic process intersection_of: GO:0009056 ! catabolic process intersection_of: RO:0004009 CHEBI:16991 ! has primary input relationship: BFO:0000051 GO:0004536 ! has part DNA nuclease activity relationship: RO:0004009 CHEBI:16991 ! has primary input [Term] id: GO:0006309 name: apoptotic DNA fragmentation namespace: biological_process def: "The cleavage of DNA during apoptosis, which usually occurs in two stages: cleavage into fragments of about 50 kbp followed by cleavage between nucleosomes to yield 200 bp fragments." [GOC:dph, GOC:mah, GOC:mtg_apoptosis, GOC:tb, ISBN:0721639976, PMID:15723341, PMID:23379520] comment: DNA fragmentation in response to apoptotic signals is achieved through the activity of apoptotic nucleases. In human, these include DNA fragmentation factor (DFF) or caspase-activated DNase (CAD) and endonuclease G (Endo G) (reviewed in PMID:15723341). Caution is needed when apoptotic DNA laddering assays show presence of fragmented DNA. A positive assay may simply reflect the end point of a whole apoptotic process. Unless clear experimental evidence is available to show that a gene product is directly involved in fragmenting DNA, please do not annotate to GO:0006309 'apoptotic DNA fragmentation' and consider annotating instead to a more upstream process such as, e.g., GO:0042981 'regulation of apoptotic process', GO:0006915 'apoptotic process', GO:0097190 'apoptotic signaling pathway'. Also, note that gene products involved in compartmentalization of apoptotic nucleases and in activation or repression of their enzymatic activity should be annotated to the regulation term GO:1902510 'regulation of apoptotic DNA fragmentation' or to one of its children (see PMID:15723341). synonym: "chromatinolysis" BROAD [GOC:mtg_apoptosis] synonym: "DNA catabolic process during apoptosis" EXACT [] synonym: "DNA catabolism during apoptosis" EXACT [] synonym: "DNA fragmentation" BROAD [] synonym: "DNA fragmentation involved in apoptotic nuclear change" EXACT [GOC:cjm, GOC:dph, GOC:tb] synonym: "endonucleolytic DNA catabolic process involved in apoptosis" EXACT [] xref: Reactome:R-HSA-140342 "Apoptosis induced DNA fragmentation" is_a: GO:0006308 ! DNA catabolic process intersection_of: GO:0006308 ! DNA catabolic process intersection_of: BFO:0000050 GO:0030262 ! part of apoptotic nuclear changes relationship: BFO:0000050 GO:0030262 ! part of apoptotic nuclear changes property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/24396" xsd:anyURI property_value: RO:0002161 NCBITaxon:4896 [Term] id: GO:0006310 name: DNA recombination namespace: biological_process def: "Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Interchromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction." [ISBN:0198506732] subset: goslim_drosophila subset: goslim_euk_cellular_processes_ribbon subset: goslim_generic subset: goslim_pombe subset: goslim_prokaryote subset: goslim_yeast is_a: GO:0006259 ! DNA metabolic process [Term] id: GO:0006325 name: chromatin organization namespace: biological_process def: "The assembly or remodeling of chromatin composed of DNA complexed with histones, other associated proteins, and sometimes RNA." [PMID:20404130] subset: goslim_generic subset: goslim_pombe subset: goslim_yeast synonym: "chromatin assembly" NARROW [] synonym: "chromatin assembly or disassembly" RELATED [] synonym: "chromatin assembly/disassembly" RELATED [] synonym: "chromatin maintenance" BROAD [] synonym: "chromatin modification" RELATED [] synonym: "chromatin organisation" EXACT [GOC:mah] synonym: "DNA replication-independent chromatin assembly" NARROW [] synonym: "DNA replication-independent chromatin organization" NARROW [] synonym: "DNA replication-independent nucleosome organisation" NARROW [] synonym: "DNA replication-independent nuclesome assembly" NARROW [] synonym: "establishment of chromatin architecture" EXACT [GOC:mah] synonym: "establishment or maintenance of chromatin architecture" EXACT [GOC:mah] synonym: "transcription-coupled nucleosome assembly" NARROW [] xref: Reactome:R-HSA-4839726 "Chromatin organization" is_a: GO:0016043 ! cellular component organization intersection_of: GO:0016043 ! cellular component organization intersection_of: RO:0002592 GO:0000785 ! results in organization of chromatin relationship: RO:0002592 GO:0000785 ! results in organization of chromatin property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/22130" xsd:anyURI property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/23549" xsd:anyURI [Term] id: GO:0006338 name: chromatin remodeling namespace: biological_process def: "A dynamic process of chromatin reorganization resulting in changes to chromatin structure. These changes allow DNA metabolic processes such as transcriptional regulation, DNA recombination, DNA repair, and DNA replication." [GOC:jid, GOC:vw, PMID:12042764, PMID:12697820] synonym: "ATP-dependent chromatin remodeling" NARROW [] synonym: "ATP-dependent chromatin remodelling" NARROW [] synonym: "chromatin modeling" EXACT [] synonym: "chromatin modelling" EXACT [] synonym: "chromatin remodelling" EXACT [] is_a: GO:0006325 ! chromatin organization property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/21732" xsd:anyURI property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/21748" xsd:anyURI [Term] id: GO:0006399 name: tRNA metabolic process namespace: biological_process def: "The chemical reactions and pathways involving tRNA, transfer RNA, a class of relatively small RNA molecules responsible for mediating the insertion of amino acids into the sequence of nascent polypeptide chains during protein synthesis. Transfer RNA is characterized by the presence of many unusual minor bases, the function of which has not been completely established." [ISBN:0198506732] subset: goslim_chembl subset: goslim_drosophila subset: goslim_generic subset: goslim_pombe synonym: "tRNA metabolism" EXACT [] is_a: GO:0016070 ! RNA metabolic process [Term] id: GO:0006401 name: RNA catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage." [ISBN:0198506732] subset: goslim_yeast synonym: "RNA breakdown" EXACT [] synonym: "RNA catabolism" EXACT [] synonym: "RNA degradation" EXACT [] is_a: GO:0016070 ! RNA metabolic process is_a: GO:0141188 ! nucleic acid catabolic process intersection_of: GO:0009056 ! catabolic process intersection_of: RO:0004009 CHEBI:33697 ! has primary input relationship: RO:0004009 CHEBI:33697 ! has primary input [Term] id: GO:0006403 name: RNA localization namespace: biological_process def: "A process in which RNA is transported to, or maintained in, a specific location." [GOC:ai] subset: goslim_drosophila synonym: "establishment and maintenance of RNA localization" EXACT [] synonym: "RNA localisation" EXACT [GOC:mah] is_a: GO:0033036 ! macromolecule localization [Term] id: GO:0006404 name: RNA import into nucleus namespace: biological_process def: "The import of RNA from the cytoplasm to the nucleus." [GOC:ma] synonym: "RNA import into cell nucleus" EXACT [] synonym: "RNA transport from cytoplasm to nucleus" EXACT [] synonym: "RNA-nucleus import" EXACT [] is_a: GO:0050658 ! RNA transport is_a: GO:0051170 ! import into nucleus intersection_of: GO:0006810 ! transport intersection_of: RO:0002338 GO:0005829 ! has target start location cytosol intersection_of: RO:0002339 GO:0031981 ! has target end location nuclear lumen intersection_of: RO:0002342 GO:0005635 ! results in transport across nuclear envelope intersection_of: RO:0004009 CHEBI:33697 ! has primary input [Term] id: GO:0006405 name: RNA export from nucleus namespace: biological_process def: "The directed movement of RNA from the nucleus to the cytoplasm." [GOC:ma] synonym: "RNA export from cell nucleus" EXACT [] synonym: "RNA export out of nucleus" EXACT [] synonym: "RNA transport from nucleus to cytoplasm" EXACT [] synonym: "RNA-nucleus export" EXACT [] is_a: GO:0050658 ! RNA transport is_a: GO:0051168 ! nuclear export intersection_of: GO:0006810 ! transport intersection_of: RO:0002338 GO:0031981 ! has target start location nuclear lumen intersection_of: RO:0002339 GO:0005829 ! has target end location cytosol intersection_of: RO:0002342 GO:0005635 ! results in transport across nuclear envelope intersection_of: RO:0004009 CHEBI:33697 ! has primary input [Term] id: GO:0006409 name: tRNA export from nucleus namespace: biological_process def: "The directed movement of tRNA from the nucleus to the cytoplasm." [GOC:ma] synonym: "tRNA export from cell nucleus" EXACT [] synonym: "tRNA export out of nucleus" EXACT [] synonym: "tRNA transport from nucleus to cytoplasm" EXACT [] synonym: "tRNA-nucleus export" EXACT [] is_a: GO:0006405 ! RNA export from nucleus is_a: GO:0051031 ! tRNA transport intersection_of: GO:0006810 ! transport intersection_of: RO:0002338 GO:0031981 ! has target start location nuclear lumen intersection_of: RO:0002339 GO:0005829 ! has target end location cytosol intersection_of: RO:0002342 GO:0005635 ! results in transport across nuclear envelope intersection_of: RO:0004009 CHEBI:17843 ! has primary input [Term] id: GO:0006412 name: translation namespace: biological_process def: "The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators] subset: goslim_candida subset: goslim_chembl subset: goslim_drosophila subset: goslim_euk_cellular_processes_ribbon subset: goslim_metagenomics subset: goslim_pir subset: goslim_plant subset: goslim_prokaryote subset: goslim_prokaryote_ribbon synonym: "protein translation" EXACT [] xref: Reactome:R-HSA-72766 "Translation" xref: Wikipedia:Translation_(genetics) is_a: GO:0009059 ! macromolecule biosynthetic process is_a: GO:0019538 ! protein metabolic process intersection_of: GO:0009058 ! biosynthetic process intersection_of: BFO:0000050 GO:0010467 ! part of gene expression intersection_of: BFO:0000051 GO:0000048 ! has part peptidyltransferase activity intersection_of: RO:0004008 PR:000000001 ! has primary output protein relationship: BFO:0000050 GO:0160307 ! part of protein biosynthetic process relationship: BFO:0000051 GO:0000048 ! has part peptidyltransferase activity relationship: BFO:0000051 GO:0006414 ! has part translational elongation relationship: RO:0002224 GO:0006413 ! starts with translational initiation relationship: RO:0002230 GO:0006415 ! ends with translational termination relationship: RO:0004008 PR:000000001 ! has primary output protein [Term] id: GO:0006413 name: translational initiation namespace: biological_process def: "The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA or circRNA, and an initiation complex that contains the first aminoacyl-tRNA." [ISBN:019879276X] subset: goslim_yeast synonym: "biopolymerisation" BROAD [] synonym: "biopolymerization" BROAD [] synonym: "protein synthesis initiation" BROAD [] synonym: "translation initiation" EXACT [] xref: Reactome:R-HSA-72613 "Eukaryotic Translation Initiation" is_a: BFO:0000003 is_a: GO:0008152 ! metabolic process relationship: BFO:0000050 GO:0006412 ! part of translation relationship: RO:0002224 GO:0001677 ! starts with formation of translation initiation ternary complex [Term] id: GO:0006414 name: translational elongation namespace: biological_process def: "The successive addition of amino acid residues to a nascent polypeptide chain during protein biosynthesis." [GOC:ems] subset: goslim_yeast synonym: "protein synthesis elongation" BROAD [] synonym: "translation elongation" EXACT [] xref: Reactome:R-HSA-156842 "Eukaryotic Translation Elongation" is_a: GO:0009059 ! macromolecule biosynthetic process relationship: BFO:0000050 GO:0006412 ! part of translation [Term] id: GO:0006415 name: translational termination namespace: biological_process def: "The process resulting in the release of a polypeptide chain from the ribosome, usually in response to a termination codon (UAA, UAG, or UGA in the universal genetic code)." [GOC:hjd, ISBN:019879276X] synonym: "protein synthesis termination" BROAD [] synonym: "translation termination" EXACT [] synonym: "translational complex disassembly" EXACT [] xref: Reactome:R-HSA-72764 "Eukaryotic Translation Termination" is_a: GO:0032984 ! protein-containing complex disassembly relationship: BFO:0000050 GO:0006412 ! part of translation [Term] id: GO:0006417 name: regulation of translation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA." [GOC:isa_complete] subset: goslim_yeast synonym: "regulation of protein anabolism" EXACT [] synonym: "regulation of protein biosynthesis" EXACT [] synonym: "regulation of protein formation" EXACT [] synonym: "regulation of protein synthesis" EXACT [] is_a: GO:0010608 ! post-transcriptional regulation of gene expression is_a: GO:0051246 ! regulation of protein metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0006412 ! regulates translation relationship: RO:0002211 GO:0006412 ! regulates translation [Term] id: GO:0006446 name: regulation of translational initiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of translational initiation." [GOC:go_curators] is_a: GO:0006417 ! regulation of translation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0006413 ! regulates translational initiation relationship: RO:0002211 GO:0006413 ! regulates translational initiation [Term] id: GO:0006448 name: regulation of translational elongation namespace: biological_process def: "Any process that modulates the frequency, rate, extent or accuracy of translational elongation." [GOC:go_curators] is_a: GO:0006417 ! regulation of translation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0006414 ! regulates translational elongation relationship: RO:0002211 GO:0006414 ! regulates translational elongation [Term] id: GO:0006449 name: regulation of translational termination namespace: biological_process def: "Any process that modulates the frequency, rate or extent of translational termination." [GOC:go_curators] is_a: GO:0006417 ! regulation of translation is_a: GO:0043244 ! regulation of protein-containing complex disassembly intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0006415 ! regulates translational termination relationship: RO:0002211 GO:0006415 ! regulates translational termination [Term] id: GO:0006468 name: protein phosphorylation namespace: biological_process def: "The process of introducing a phosphate group on to a protein." [GOC:hb] subset: gocheck_obsoletion_candidate subset: goslim_yeast synonym: "protein amino acid phosphorylation" EXACT [GOC:bf] is_a: GO:0016310 ! phosphorylation is_a: GO:0036211 ! protein modification process [Term] id: GO:0006469 name: negative regulation of protein kinase activity namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of protein kinase activity." [GOC:go_curators] subset: gocheck_obsoletion_candidate synonym: "down regulation of protein kinase activity" EXACT [] synonym: "down-regulation of protein kinase activity" EXACT [] synonym: "downregulation of protein kinase activity" EXACT [] synonym: "inhibition of protein kinase activity" NARROW [] is_a: GO:0001933 ! negative regulation of protein phosphorylation is_a: GO:0033673 ! negative regulation of kinase activity is_a: GO:0045859 ! regulation of protein kinase activity intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0004672 ! negatively regulates protein kinase activity relationship: RO:0002212 GO:0004672 ! negatively regulates protein kinase activity [Term] id: GO:0006493 name: protein O-linked glycosylation namespace: biological_process def: "A glycoprotein biosynthetic process starting with the covalent linkage of carbohydrate or carbohydrate derivative unit via a glycosidic bond to the oxygen atom of a serine, threonine, hydroxylysine, hydroxyproline or tyrosine side chain in a protein, which can be further elongated with the sequential addition of sugar units resulting in the formation of a protein O-linked glycan." [PMID:33775405] synonym: "protein amino acid O-linked glycosylation" EXACT [GOC:bf] xref: Reactome:R-HSA-5173105 "O-linked glycosylation" xref: RESID:AA0153 xref: RESID:AA0154 xref: RESID:AA0155 xref: RESID:AA0157 xref: RESID:AA0212 is_a: GO:0009101 ! glycoprotein biosynthetic process property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/29770" xsd:anyURI [Term] id: GO:0006508 name: proteolysis namespace: biological_process def: "The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah] comment: This term was intentionally placed under 'protein metabolic process ; GO:0019538' rather than 'protein catabolic process ; GO:0030163' to cover all processes centered on breaking peptide bonds, including those involved in protein processing. subset: goslim_chembl subset: goslim_metagenomics subset: goslim_pir synonym: "ATP-dependent proteolysis" NARROW [GOC:mah] synonym: "peptidolysis" EXACT [] xref: Wikipedia:Proteolysis is_a: GO:0019538 ! protein metabolic process [Term] id: GO:0006516 name: glycoprotein catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of a glycoprotein, a protein that contains covalently bound glycose (i.e. monosaccharide) residues; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide." [GOC:go_curators, ISBN:0198506732] synonym: "glycoprotein breakdown" EXACT [] synonym: "glycoprotein catabolism" EXACT [] synonym: "glycoprotein degradation" EXACT [] is_a: GO:0009100 ! glycoprotein metabolic process is_a: GO:0030163 ! protein catabolic process is_a: GO:1901136 ! carbohydrate derivative catabolic process intersection_of: GO:0009056 ! catabolic process intersection_of: RO:0004009 CHEBI:17089 ! has primary input relationship: RO:0004009 CHEBI:17089 ! has primary input [Term] id: GO:0006518 name: peptide metabolic process namespace: biological_process def: "The chemical reactions and pathways involving peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another." [GOC:go_curators] subset: goslim_pir synonym: "peptide metabolism" EXACT [] xref: Reactome:R-HSA-2980736 "Peptide hormone metabolism" is_a: BFO:0000003 is_a: GO:0008152 ! metabolic process intersection_of: GO:0008152 ! metabolic process intersection_of: RO:0004007 CHEBI:60466 ! has primary input or output relationship: RO:0004007 CHEBI:60466 ! has primary input or output [Term] id: GO:0006520 name: amino acid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving amino acids, carboxylic acids containing one or more amino groups." [ISBN:0198506732] subset: goslim_chembl subset: goslim_drosophila subset: goslim_generic subset: goslim_pir subset: goslim_pombe subset: goslim_prokaryote subset: goslim_prokaryote_ribbon subset: goslim_yeast synonym: "amino acid and derivative metabolism" RELATED [] synonym: "cellular amino acid and derivative metabolic process" RELATED [] synonym: "cellular amino acid metabolic process" EXACT [] synonym: "cellular amino acid metabolism" EXACT [] is_a: BFO:0000003 is_a: GO:0044238 ! primary metabolic process intersection_of: GO:0008152 ! metabolic process intersection_of: RO:0004007 CHEBI:35238 ! has primary input or output relationship: RO:0004007 CHEBI:35238 ! has primary input or output property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/17904" xsd:anyURI [Term] id: GO:0006521 name: regulation of amino acid metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving amino acids." [GOC:go_curators] synonym: "regulation of amino acid metabolism" EXACT [] xref: Reactome:R-HSA-350562 "Regulation of ornithine decarboxylase (ODC)" is_a: GO:0080090 ! regulation of primary metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0006520 ! regulates amino acid metabolic process relationship: RO:0002211 GO:0006520 ! regulates amino acid metabolic process property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/28908" xsd:anyURI [Term] id: GO:0006536 name: glutamate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving glutamate, the anion of 2-aminopentanedioic acid." [GOC:go_curators] synonym: "glutamate metabolism" EXACT [] synonym: "glutamic acid metabolic process" EXACT [] synonym: "glutamic acid metabolism" EXACT [] xref: Wikipedia:Glutamic_acid is_a: GO:0009064 ! glutamine family amino acid metabolic process is_a: GO:0043648 ! dicarboxylic acid metabolic process intersection_of: GO:0008152 ! metabolic process intersection_of: RO:0004007 CHEBI:14321 ! has primary input or output relationship: RO:0004007 CHEBI:14321 ! has primary input or output [Term] id: GO:0006537 name: glutamate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of glutamate, the anion of 2-aminopentanedioic acid." [GOC:go_curators] synonym: "glutamate anabolism" EXACT [] synonym: "glutamate biosynthesis" EXACT [] synonym: "glutamate biosynthesis, using glutamate dehydrogenase (NAD(P)+)" NARROW [] synonym: "glutamate biosynthesis, using glutamate synthase (NADPH)" NARROW [] synonym: "glutamate biosynthetic process, using glutamate dehydrogenase (NAD(P)+)" NARROW [] synonym: "glutamate biosynthetic process, using glutamate synthase (NADPH)" NARROW [] synonym: "glutamate formation" EXACT [] synonym: "glutamate synthesis" EXACT [] synonym: "glutamic acid biosynthesis" EXACT [] synonym: "glutamic acid biosynthetic process" EXACT [] is_a: GO:0006536 ! glutamate metabolic process is_a: GO:0009084 ! glutamine family amino acid biosynthetic process is_a: GO:0043650 ! dicarboxylic acid biosynthetic process intersection_of: GO:0009058 ! biosynthetic process intersection_of: RO:0004008 CHEBI:14321 ! has primary output relationship: RO:0004008 CHEBI:14321 ! has primary output [Term] id: GO:0006538 name: L-glutamate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of L-glutamate, the anion of 2-aminopentanedioic acid." [GOC:go_curators] synonym: "glutamate breakdown" EXACT [] synonym: "glutamate catabolism" EXACT [] synonym: "glutamate deamidation" RELATED [] synonym: "glutamate degradation" EXACT [] synonym: "glutamic acid catabolic process" EXACT [] synonym: "glutamic acid catabolism" EXACT [] is_a: GO:0006536 ! glutamate metabolic process is_a: GO:0043649 ! dicarboxylic acid catabolic process is_a: GO:0170035 ! L-amino acid catabolic process is_a: GO:0170040 ! proteinogenic amino acid catabolic process intersection_of: GO:0009056 ! catabolic process intersection_of: RO:0004009 CHEBI:29985 ! has primary input relationship: RO:0004009 CHEBI:29985 ! has primary input property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/30202" xsd:anyURI [Term] id: GO:0006544 name: glycine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving glycine, aminoethanoic acid." [GOC:go_curators] synonym: "glycine metabolism" EXACT [] is_a: GO:0170039 ! proteinogenic amino acid metabolic process is_a: GO:1901605 ! alpha-amino acid metabolic process intersection_of: GO:0008152 ! metabolic process intersection_of: RO:0004007 CHEBI:57305 ! has primary input or output relationship: RO:0004007 CHEBI:57305 ! has primary input or output [Term] id: GO:0006545 name: glycine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of glycine, aminoethanoic acid." [GOC:go_curators] synonym: "glycine anabolism" EXACT [] synonym: "glycine biosynthesis" EXACT [] synonym: "glycine formation" EXACT [] synonym: "glycine synthesis" EXACT [] xref: MetaCyc:GLYCINE-SYN2-PWY is_a: GO:0006544 ! glycine metabolic process is_a: GO:0009070 ! serine family amino acid biosynthetic process is_a: GO:0170038 ! proteinogenic amino acid biosynthetic process intersection_of: GO:0009058 ! biosynthetic process intersection_of: RO:0004008 CHEBI:57305 ! has primary output relationship: RO:0004008 CHEBI:57305 ! has primary output [Term] id: GO:0006546 name: glycine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of glycine, aminoethanoic acid." [GOC:go_curators] synonym: "glycine breakdown" EXACT [] synonym: "glycine catabolism" EXACT [] synonym: "glycine degradation" EXACT [] xref: Reactome:R-HSA-6783984 "Glycine degradation" is_a: GO:0006544 ! glycine metabolic process is_a: GO:0170040 ! proteinogenic amino acid catabolic process is_a: GO:1901606 ! alpha-amino acid catabolic process intersection_of: GO:0009056 ! catabolic process intersection_of: RO:0004009 CHEBI:57305 ! has primary input relationship: RO:0004009 CHEBI:57305 ! has primary input [Term] id: GO:0006547 name: L-histidine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving L-histidine, 2-amino-3-(1H-imidazol-4-yl)propanoic acid." [GOC:go_curators] synonym: "histidine metabolic process" BROAD [] synonym: "histidine metabolism" EXACT [] xref: Wikipedia:Histidine is_a: GO:0009072 ! aromatic amino acid metabolic process is_a: GO:0052803 ! imidazole-containing compound metabolic process is_a: GO:0170033 ! L-amino acid metabolic process is_a: GO:0170039 ! proteinogenic amino acid metabolic process intersection_of: GO:0008152 ! metabolic process intersection_of: RO:0004007 CHEBI:57595 ! has primary input or output relationship: RO:0004007 CHEBI:57595 ! has primary input or output [Term] id: GO:0006548 name: L-histidine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of L-histidine, 2-amino-3-(1H-imidazol-4-yl)propanoic acid." [GOC:go_curators] synonym: "histidine breakdown" EXACT [] synonym: "histidine catabolic process" BROAD [] synonym: "histidine catabolism" EXACT [] synonym: "histidine degradation" EXACT [] xref: Reactome:R-HSA-70921 "Histidine catabolism" is_a: GO:0006547 ! L-histidine metabolic process is_a: GO:0009074 ! aromatic amino acid family catabolic process is_a: GO:0052805 ! imidazole-containing compound catabolic process is_a: GO:0170035 ! L-amino acid catabolic process is_a: GO:0170040 ! proteinogenic amino acid catabolic process intersection_of: GO:0009056 ! catabolic process intersection_of: RO:0004009 CHEBI:57595 ! has primary input relationship: RO:0004009 CHEBI:57595 ! has primary input [Term] id: GO:0006575 name: modified amino acid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving compounds derived from amino acids, organic acids containing one or more amino substituents." [GOC:ai] subset: goslim_drosophila subset: goslim_generic subset: goslim_prokaryote synonym: "amino acid derivative metabolic process" EXACT [] synonym: "cellular amino acid derivative metabolic process" EXACT [] synonym: "cellular amino acid derivative metabolism" EXACT [] synonym: "cellular modified amino acid metabolic process" EXACT [GOC:mah] synonym: "cellular modified amino acid metabolism" EXACT [GOC:mah] synonym: "modified amino acid metabolism" EXACT [GOC:mah] is_a: BFO:0000003 is_a: GO:0008152 ! metabolic process intersection_of: GO:0008152 ! metabolic process intersection_of: RO:0004007 CHEBI:83821 ! has primary input or output relationship: RO:0004007 CHEBI:83821 ! has primary input or output property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/28908" xsd:anyURI [Term] id: GO:0006576 name: biogenic amine metabolic process namespace: biological_process def: "The chemical reactions and pathways occurring at the level of individual cells involving any of a group of naturally occurring, biologically active amines, such as norepinephrine, histamine, and serotonin, many of which act as neurotransmitters." [GOC:jl, ISBN:0395825172] synonym: "biogenic amine metabolism" EXACT [] synonym: "cellular biogenic amine metabolic process" EXACT [] is_a: GO:0009308 ! amine metabolic process [Term] id: GO:0006581 name: acetylcholine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of acetylcholine, the acetic acid ester of the organic base choline." [GOC:jl, ISBN:0192800752] synonym: "acetylcholine breakdown" EXACT [] synonym: "acetylcholine catabolism" EXACT [] synonym: "acetylcholine degradation" EXACT [] is_a: GO:0008291 ! acetylcholine metabolic process is_a: GO:0009056 ! catabolic process intersection_of: GO:0009056 ! catabolic process intersection_of: RO:0004009 CHEBI:15355 ! has primary input relationship: RO:0004009 CHEBI:15355 ! has primary input [Term] id: GO:0006584 name: catecholamine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving any of a group of physiologically important biogenic amines that possess a catechol (3,4-dihydroxyphenyl) nucleus and are derivatives of 3,4-dihydroxyphenylethylamine." [GOC:jl, ISBN:0198506732] synonym: "catecholamine metabolism" EXACT [] is_a: GO:0006576 ! biogenic amine metabolic process is_a: GO:0009712 ! catechol-containing compound metabolic process intersection_of: GO:0008152 ! metabolic process intersection_of: RO:0004007 CHEBI:33567 ! has primary input or output relationship: RO:0004007 CHEBI:33567 ! has primary input or output [Term] id: GO:0006590 name: thyroid hormone generation namespace: biological_process def: "The formation of either of the compounds secreted by the thyroid gland, mainly thyroxine and triiodothyronine. This is achieved by the iodination and joining of tyrosine molecules to form the precursor thyroglobin, proteolysis of this precursor gives rise to the thyroid hormones." [GOC:jl, ISBN:0716720094] comment: Note that this term does not fall under the general GO definition for biosynthetic processes, which is 'The chemical reactions and pathways resulting in the formation of... ', because thyroid hormones can only be formed by the proteolysis of a larger molecule (see term definition). The word 'generation' is therefore used in place of biosynthesis. xref: Reactome:R-HSA-209968 "Thyroxine biosynthesis" is_a: GO:0042403 ! thyroid hormone metabolic process property_value: RO:0002161 NCBITaxon:4895 [Term] id: GO:0006606 name: protein import into nucleus namespace: biological_process def: "The directed movement of a protein from the cytoplasm to the nucleus." [GOC:jl] synonym: "establishment of protein localization to nucleus" EXACT [GOC:mah] synonym: "protein import into cell nucleus" EXACT [] synonym: "protein nucleus import" EXACT [] synonym: "protein transport from cytoplasm to nucleus" EXACT [] is_a: GO:0006886 ! intracellular protein transport is_a: GO:0034504 ! protein localization to nucleus is_a: GO:0051170 ! import into nucleus is_a: GO:0072594 ! establishment of protein localization to organelle intersection_of: GO:0006810 ! transport intersection_of: RO:0002338 GO:0005829 ! has target start location cytosol intersection_of: RO:0002339 GO:0031981 ! has target end location nuclear lumen intersection_of: RO:0002342 GO:0005635 ! results in transport across nuclear envelope intersection_of: RO:0004009 PR:000000001 ! has primary input protein [Term] id: GO:0006611 name: protein export from nucleus namespace: biological_process def: "The directed movement of a protein from the nucleus into the cytoplasm." [GOC:jl] synonym: "copper-induced protein export from nucleus" RELATED [GOC:al] synonym: "protein export from cell nucleus" EXACT [] synonym: "protein export out of nucleus" EXACT [] synonym: "protein transport from nucleus to cytoplasm" EXACT [] synonym: "protein-nucleus export" EXACT [] is_a: GO:0006886 ! intracellular protein transport is_a: GO:0051168 ! nuclear export intersection_of: GO:0006810 ! transport intersection_of: RO:0002338 GO:0031981 ! has target start location nuclear lumen intersection_of: RO:0002339 GO:0005829 ! has target end location cytosol intersection_of: RO:0002342 GO:0005635 ! results in transport across nuclear envelope intersection_of: RO:0004009 PR:000000001 ! has primary input protein [Term] id: GO:0006624 name: vacuolar protein processing namespace: biological_process def: "Protein processing that takes place in the vacuole. Most protein processing in the vacuole represents proteolytic cleavage of precursors to form active enzymes." [GOC:mah] synonym: "vacuolar protein maturation" RELATED [] synonym: "vacuolar proteolysis" RELATED [] is_a: GO:0016485 ! protein processing intersection_of: GO:0016485 ! protein processing intersection_of: BFO:0000066 GO:0005773 ! occurs in vacuole relationship: BFO:0000066 GO:0005773 ! occurs in vacuole [Term] id: GO:0006629 name: lipid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma] subset: goslim_agr subset: goslim_candida subset: goslim_chembl subset: goslim_drosophila subset: goslim_euk_cellular_processes_ribbon subset: goslim_generic subset: goslim_metagenomics subset: goslim_mouse subset: goslim_pir subset: goslim_plant subset: goslim_plant_ribbon subset: goslim_pombe subset: goslim_prokaryote subset: goslim_prokaryote_ribbon subset: goslim_yeast synonym: "lipid metabolism" EXACT [] xref: Reactome:R-HSA-556833 "Metabolism of lipids" xref: Wikipedia:Lipid_metabolism is_a: BFO:0000003 is_a: GO:0044238 ! primary metabolic process intersection_of: GO:0008152 ! metabolic process intersection_of: RO:0004007 CHEBI:18059 ! has primary input or output relationship: RO:0004007 CHEBI:18059 ! has primary input or output [Term] id: GO:0006631 name: fatty acid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving fatty acids, aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis." [ISBN:0198547684] synonym: "fatty acid metabolism" EXACT [] xref: Reactome:R-HSA-211935 "Fatty acids" xref: Reactome:R-HSA-434313 "Intracellular metabolism of fatty acids regulates insulin secretion" xref: Reactome:R-HSA-8978868 "Fatty acid metabolism" xref: Wikipedia:Fatty_acid_metabolism is_a: GO:0006629 ! lipid metabolic process is_a: GO:0032787 ! monocarboxylic acid metabolic process intersection_of: GO:0008152 ! metabolic process intersection_of: RO:0004007 CHEBI:28868 ! has primary input or output relationship: RO:0004007 CHEBI:28868 ! has primary input or output property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/28908" xsd:anyURI [Term] id: GO:0006633 name: fatty acid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes." [GOC:mah, ISBN:0198506732] synonym: "fatty acid anabolism" EXACT [] synonym: "fatty acid biosynthesis" EXACT [] synonym: "fatty acid formation" EXACT [] synonym: "fatty acid synthesis" EXACT [] xref: MetaCyc:FASYN-INITIAL-PWY {source="skos:narrowMatch"} xref: MetaCyc:PWY-4381 {source="skos:narrowMatch"} xref: MetaCyc:PWY-5156 {source="skos:narrowMatch"} xref: Wikipedia:Fatty_acid_synthesis is_a: GO:0006631 ! fatty acid metabolic process is_a: GO:0008610 ! lipid biosynthetic process is_a: GO:0072330 ! monocarboxylic acid biosynthetic process intersection_of: GO:0009058 ! biosynthetic process intersection_of: RO:0004008 CHEBI:28868 ! has primary output relationship: RO:0004008 CHEBI:28868 ! has primary output property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/28527" xsd:anyURI [Term] id: GO:0006643 name: membrane lipid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving membrane lipids, any lipid found in or associated with a biological membrane." [GOC:ai] synonym: "membrane lipid metabolism" EXACT [] is_a: GO:0006629 ! lipid metabolic process intersection_of: GO:0008152 ! metabolic process intersection_of: BFO:0000066 GO:0016020 ! occurs in membrane intersection_of: RO:0004007 CHEBI:18059 ! has primary input or output relationship: BFO:0000066 GO:0016020 ! occurs in membrane property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/28908" xsd:anyURI [Term] id: GO:0006664 name: glycolipid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving glycolipids, a class of 1,2-di-O-acylglycerols joined at oxygen 3 by a glycosidic linkage to a carbohydrate part (usually a mono-, di- or tri-saccharide). Some substances classified as bacterial glycolipids have the sugar group acylated by one or more fatty acids and the glycerol group may be absent." [ISBN:0198547684] synonym: "glycolipid metabolism" EXACT [] is_a: GO:0006643 ! membrane lipid metabolic process is_a: GO:1903509 ! liposaccharide metabolic process intersection_of: GO:0008152 ! metabolic process intersection_of: RO:0004007 CHEBI:33563 ! has primary input or output relationship: RO:0004007 CHEBI:33563 ! has primary input or output [Term] id: GO:0006665 name: sphingolipid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving sphingolipids, any of a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid)." [GOC:mah, ISBN:0198506732] synonym: "sphingolipid metabolism" EXACT [] xref: Reactome:R-HSA-428157 "Sphingolipid metabolism" is_a: GO:0006643 ! membrane lipid metabolic process intersection_of: GO:0008152 ! metabolic process intersection_of: RO:0004007 CHEBI:26739 ! has primary input or output relationship: RO:0004007 CHEBI:26739 ! has primary input or output [Term] id: GO:0006687 name: glycosphingolipid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving glycosphingolipids, any compound with residues of sphingoid and at least one monosaccharide." [ISBN:0198547684] synonym: "glycosphingolipid metabolism" EXACT [] xref: Reactome:R-HSA-1660662 "Glycosphingolipid metabolism" is_a: GO:0006664 ! glycolipid metabolic process is_a: GO:0006665 ! sphingolipid metabolic process intersection_of: GO:0008152 ! metabolic process intersection_of: RO:0004007 CHEBI:24402 ! has primary input or output relationship: RO:0004007 CHEBI:24402 ! has primary input or output [Term] id: GO:0006688 name: glycosphingolipid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a glycosphingolipid, a compound composed of a ceramide backbone covalently linked to at least one carbohydrate moiety." [PMID:35536927] synonym: "glycosphingolipid anabolism" EXACT [] synonym: "glycosphingolipid biosynthesis" EXACT [] synonym: "glycosphingolipid formation" EXACT [] synonym: "glycosphingolipid synthesis" EXACT [] synonym: "glycosylceramide biosynthetic process" EXACT [] xref: Reactome:R-HSA-9840309 "Glycosphingolipid biosynthesis" is_a: GO:0006687 ! glycosphingolipid metabolic process is_a: GO:0009247 ! glycolipid biosynthetic process is_a: GO:0030148 ! sphingolipid biosynthetic process intersection_of: GO:0009058 ! biosynthetic process intersection_of: RO:0004008 CHEBI:24402 ! has primary output relationship: RO:0004008 CHEBI:24402 ! has primary output property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/30616" xsd:anyURI [Term] id: GO:0006694 name: steroid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus; includes de novo formation and steroid interconversion by modification." [GOC:go_curators] synonym: "steroid anabolism" EXACT [] synonym: "steroid biosynthesis" EXACT [] synonym: "steroid formation" EXACT [] synonym: "steroid synthesis" EXACT [] synonym: "steroidogenesis" EXACT [] xref: Wikipedia:Steroid_metabolisms#Steroid_biosynthesis is_a: GO:0008202 ! steroid metabolic process is_a: GO:0008610 ! lipid biosynthetic process intersection_of: GO:0009058 ! biosynthetic process intersection_of: RO:0004008 CHEBI:35341 ! has primary output relationship: RO:0004008 CHEBI:35341 ! has primary output [Term] id: GO:0006699 name: bile acid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of bile acids, any of a group of steroid carboxylic acids occurring in bile." [GOC:go_curators] synonym: "bile acid anabolism" EXACT [] synonym: "bile acid biosynthesis" EXACT [] synonym: "bile acid formation" EXACT [] synonym: "bile acid synthesis" EXACT [] xref: Reactome:R-HSA-192105 "Synthesis of bile acids and bile salts" is_a: GO:0008206 ! bile acid metabolic process is_a: GO:0072330 ! monocarboxylic acid biosynthetic process intersection_of: GO:0009058 ! biosynthetic process intersection_of: RO:0004008 CHEBI:36235 ! has primary output relationship: RO:0002162 NCBITaxon:6072 ! in taxon Eumetazoa relationship: RO:0004008 CHEBI:36235 ! has primary output [Term] id: GO:0006700 name: C21-steroid hormone biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of C21-steroid hormones, steroid compounds containing 21 carbons which function as hormones." [GOC:ai] synonym: "C21-steroid hormone anabolism" EXACT [] synonym: "C21-steroid hormone biosynthesis" EXACT [] synonym: "C21-steroid hormone formation" EXACT [] synonym: "C21-steroid hormone synthesis" EXACT [] xref: Reactome:R-HSA-196108 "Pregnenolone biosynthesis" is_a: GO:0008207 ! C21-steroid hormone metabolic process is_a: GO:0042446 ! hormone biosynthetic process is_a: GO:0120178 ! steroid hormone biosynthetic process intersection_of: GO:0009058 ! biosynthetic process intersection_of: RO:0004008 CHEBI:64600 ! has primary output relationship: RO:0004008 CHEBI:64600 ! has primary output property_value: RO:0002161 NCBITaxon:4895 [Term] id: GO:0006701 name: progesterone biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of progesterone, a steroid hormone produced in the ovary which prepares and maintains the uterus for pregnancy. Also found in plants." [GOC:jl, PMID:14613534] synonym: "progesterone anabolism" EXACT [] synonym: "progesterone biosynthesis" EXACT [] synonym: "progesterone formation" EXACT [] synonym: "progesterone synthesis" EXACT [] is_a: GO:0006700 ! C21-steroid hormone biosynthetic process is_a: GO:0042181 ! ketone biosynthetic process is_a: GO:0042448 ! progesterone metabolic process is_a: GO:0120255 ! olefinic compound biosynthetic process intersection_of: GO:0009058 ! biosynthetic process intersection_of: RO:0004008 CHEBI:17026 ! has primary output relationship: RO:0004008 CHEBI:17026 ! has primary output property_value: RO:0002161 NCBITaxon:4895 [Term] id: GO:0006704 name: glucocorticoid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of glucocorticoids, hormonal C21 corticosteroids synthesized from cholesterol." [ISBN:0198506732] synonym: "glucocorticoid anabolism" EXACT [] synonym: "glucocorticoid biosynthesis" EXACT [] synonym: "glucocorticoid formation" EXACT [] synonym: "glucocorticoid synthesis" EXACT [] xref: Reactome:R-HSA-194002 "Glucocorticoid biosynthesis" is_a: GO:0008211 ! glucocorticoid metabolic process is_a: GO:0120178 ! steroid hormone biosynthetic process intersection_of: GO:0009058 ! biosynthetic process intersection_of: RO:0004008 CHEBI:24261 ! has primary output relationship: RO:0004008 CHEBI:24261 ! has primary output [Term] id: GO:0006705 name: mineralocorticoid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of mineralocorticoids, hormonal C21 corticosteroids synthesized from cholesterol." [ISBN:0198506732] synonym: "mineralocorticoid anabolism" EXACT [] synonym: "mineralocorticoid biosynthesis" EXACT [] synonym: "mineralocorticoid formation" EXACT [] synonym: "mineralocorticoid synthesis" EXACT [] xref: Reactome:R-HSA-193993 "Mineralocorticoid biosynthesis" is_a: GO:0008212 ! mineralocorticoid metabolic process is_a: GO:0042446 ! hormone biosynthetic process is_a: GO:0120178 ! steroid hormone biosynthetic process intersection_of: GO:0009058 ! biosynthetic process intersection_of: RO:0004008 CHEBI:25354 ! has primary output relationship: RO:0004008 CHEBI:25354 ! has primary output property_value: RO:0002161 NCBITaxon:4895 [Term] id: GO:0006706 name: steroid catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus." [GOC:go_curators] synonym: "steroid breakdown" EXACT [] synonym: "steroid catabolism" EXACT [] synonym: "steroid degradation" EXACT [] is_a: GO:0008202 ! steroid metabolic process is_a: GO:0016042 ! lipid catabolic process intersection_of: GO:0009056 ! catabolic process intersection_of: RO:0004009 CHEBI:35341 ! has primary input relationship: RO:0004009 CHEBI:35341 ! has primary input [Term] id: GO:0006709 name: progesterone catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of progesterone, a steroid hormone produced in the ovary which prepares and maintains the uterus for pregnancy. Also found in plants." [GOC:jl, PMID:11392024] synonym: "progesterone breakdown" EXACT [] synonym: "progesterone catabolism" EXACT [] synonym: "progesterone degradation" EXACT [] is_a: GO:0008208 ! C21-steroid hormone catabolic process is_a: GO:0042182 ! ketone catabolic process is_a: GO:0042448 ! progesterone metabolic process is_a: GO:0120256 ! olefinic compound catabolic process intersection_of: GO:0009056 ! catabolic process intersection_of: RO:0004009 CHEBI:17026 ! has primary input relationship: RO:0004009 CHEBI:17026 ! has primary input property_value: RO:0002161 NCBITaxon:4895 [Term] id: GO:0006712 name: mineralocorticoid catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of mineralocorticoids, hormonal C21 corticosteroids synthesized from cholesterol." [ISBN:0198506732] synonym: "mineralocorticoid breakdown" EXACT [] synonym: "mineralocorticoid catabolism" EXACT [] synonym: "mineralocorticoid degradation" EXACT [] is_a: GO:0006706 ! steroid catabolic process is_a: GO:0008212 ! mineralocorticoid metabolic process is_a: GO:0042447 ! hormone catabolic process intersection_of: GO:0009056 ! catabolic process intersection_of: RO:0004009 CHEBI:25354 ! has primary input relationship: RO:0004009 CHEBI:25354 ! has primary input property_value: RO:0002161 NCBITaxon:4895 [Term] id: GO:0006713 name: glucocorticoid catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of glucocorticoids, hormonal C21 corticosteroids synthesized from cholesterol." [ISBN:0198506732] synonym: "glucocorticoid breakdown" EXACT [] synonym: "glucocorticoid catabolism" EXACT [] synonym: "glucocorticoid degradation" EXACT [] is_a: GO:0006706 ! steroid catabolic process is_a: GO:0008211 ! glucocorticoid metabolic process intersection_of: GO:0009056 ! catabolic process intersection_of: RO:0004009 CHEBI:24261 ! has primary input relationship: RO:0004009 CHEBI:24261 ! has primary input [Term] id: GO:0006714 name: sesquiterpenoid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving sesquiterpenoid compounds, terpenoids with three isoprene units." [ISBN:0198547684] synonym: "sesquiterpenoid metabolism" EXACT [] is_a: GO:0006721 ! terpenoid metabolic process intersection_of: GO:0008152 ! metabolic process intersection_of: RO:0004007 CHEBI:26658 ! has primary input or output relationship: RO:0004007 CHEBI:26658 ! has primary input or output [Term] id: GO:0006716 name: juvenile hormone metabolic process namespace: biological_process def: "The chemical reactions and pathways involving juvenile hormones, the three sesquiterpenoid derivatives that function to maintain the larval state of insects at molting and that may be required for other processes, e.g. oogenesis." [GOC:go_curators, ISBN:0198547684] synonym: "juvenile hormone metabolism" EXACT [] is_a: GO:0006714 ! sesquiterpenoid metabolic process is_a: GO:0042445 ! hormone metabolic process intersection_of: GO:0008152 ! metabolic process intersection_of: RO:0004007 CHEBI:24943 ! has primary input or output relationship: RO:0004007 CHEBI:24943 ! has primary input or output property_value: RO:0002161 NCBITaxon:4895 [Term] id: GO:0006718 name: juvenile hormone biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of juvenile hormones, the three sesquiterpenoid derivatives that function to maintain the larval state of insects at molting and that may be required for other processes, e.g. oogenesis." [GOC:go_curators, ISBN:0198547684] synonym: "juvenile hormone anabolism" EXACT [] synonym: "juvenile hormone biosynthesis" EXACT [] synonym: "juvenile hormone formation" EXACT [] synonym: "juvenile hormone synthesis" EXACT [] is_a: GO:0006716 ! juvenile hormone metabolic process is_a: GO:0016106 ! sesquiterpenoid biosynthetic process is_a: GO:0042446 ! hormone biosynthetic process intersection_of: GO:0009058 ! biosynthetic process intersection_of: RO:0004008 CHEBI:24943 ! has primary output relationship: RO:0004008 CHEBI:24943 ! has primary output property_value: RO:0002161 NCBITaxon:4895 [Term] id: GO:0006719 name: juvenile hormone catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of juvenile hormones, the three sesquiterpenoid derivatives that function to maintain the larval state of insects at molting and that may be required for other processes, e.g. oogenesis." [GOC:go_curators, ISBN:0198547684] synonym: "juvenile hormone breakdown" EXACT [] synonym: "juvenile hormone catabolism" EXACT [] synonym: "juvenile hormone degradation" EXACT [] is_a: GO:0006716 ! juvenile hormone metabolic process is_a: GO:0016107 ! sesquiterpenoid catabolic process is_a: GO:0042447 ! hormone catabolic process intersection_of: GO:0009056 ! catabolic process intersection_of: RO:0004009 CHEBI:24943 ! has primary input relationship: RO:0004009 CHEBI:24943 ! has primary input property_value: RO:0002161 NCBITaxon:4895 [Term] id: GO:0006720 name: isoprenoid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving isoprenoid compounds, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues." [ISBN:0198547684] synonym: "isoprenoid metabolism" EXACT [] synonym: "polyisoprenoid metabolic process" NARROW [] synonym: "polyisoprenoid metabolism" NARROW [] synonym: "polyterpene metabolic process" NARROW [] synonym: "polyterpene metabolism" NARROW [] is_a: GO:0006629 ! lipid metabolic process intersection_of: GO:0008152 ! metabolic process intersection_of: RO:0004007 CHEBI:24913 ! has primary input or output relationship: RO:0004007 CHEBI:24913 ! has primary input or output property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/28908" xsd:anyURI [Term] id: GO:0006721 name: terpenoid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving terpenoids, any member of a class of compounds characterized by an isoprenoid chemical structure and including derivatives with various functional groups." [ISBN:0198506732] synonym: "terpenoid metabolism" EXACT [] is_a: GO:0006720 ! isoprenoid metabolic process intersection_of: GO:0008152 ! metabolic process intersection_of: RO:0004007 CHEBI:26873 ! has primary input or output relationship: RO:0004007 CHEBI:26873 ! has primary input or output [Term] id: GO:0006753 name: nucleoside phosphate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving any phosphorylated nucleoside." [GOC:mah] synonym: "nucleoside phosphate metabolism" EXACT [] is_a: GO:0006796 ! phosphate-containing compound metabolic process is_a: GO:0019637 ! organophosphate metabolic process is_a: GO:0055086 ! nucleobase-containing small molecule metabolic process intersection_of: GO:0008152 ! metabolic process intersection_of: RO:0004007 CHEBI:25608 ! has primary input or output relationship: RO:0004007 CHEBI:25608 ! has primary input or output [Term] id: GO:0006754 name: ATP biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [GOC:go_curators, ISBN:0198506732] synonym: "ATP anabolism" EXACT [] synonym: "ATP biosynthesis" EXACT [] synonym: "ATP formation" EXACT [] synonym: "ATP regeneration" NARROW [] synonym: "ATP synthesis" EXACT [] is_a: GO:0009152 ! purine ribonucleotide biosynthetic process is_a: GO:0009206 ! purine ribonucleoside triphosphate biosynthetic process is_a: GO:0046034 ! ATP metabolic process intersection_of: GO:0009058 ! biosynthetic process intersection_of: RO:0004008 CHEBI:30616 ! has primary output relationship: RO:0004008 CHEBI:30616 ! has primary output [Term] id: GO:0006790 name: sulfur compound metabolic process namespace: biological_process def: "The chemical reactions and pathways involving the nonmetallic element sulfur or compounds that contain sulfur, such as the amino acids methionine and cysteine or the tripeptide glutathione." [GOC:ai] subset: goslim_chembl subset: goslim_drosophila subset: goslim_generic subset: goslim_pir subset: goslim_pombe subset: goslim_prokaryote synonym: "sulfur metabolism" EXACT [] synonym: "sulphur metabolic process" EXACT [] synonym: "sulphur metabolism" EXACT [] xref: Wikipedia:Sulfur_metabolism is_a: BFO:0000003 is_a: GO:0008152 ! metabolic process intersection_of: GO:0008152 ! metabolic process intersection_of: RO:0004007 CHEBI:26835 ! has primary input or output relationship: RO:0004007 CHEBI:26835 ! has primary input or output [Term] id: GO:0006793 name: phosphorus metabolic process namespace: biological_process def: "The chemical reactions and pathways involving the nonmetallic element phosphorus or compounds that contain phosphorus." [GOC:ai] subset: goslim_pir synonym: "phosphorus metabolism" EXACT [] is_a: BFO:0000003 is_a: GO:0008152 ! metabolic process intersection_of: GO:0008152 ! metabolic process intersection_of: RO:0004007 CHEBI:26082 ! has primary input or output relationship: RO:0004007 CHEBI:26082 ! has primary input or output [Term] id: GO:0006796 name: phosphate-containing compound metabolic process namespace: biological_process def: "The chemical reactions and pathways involving the phosphate group, the anion or salt of any phosphoric acid." [GOC:ai] synonym: "phosphate metabolic process" RELATED [] synonym: "phosphate metabolism" EXACT [] is_a: GO:0006793 ! phosphorus metabolic process intersection_of: GO:0008152 ! metabolic process intersection_of: RO:0004007 CHEBI:26020 ! has primary input or output relationship: RO:0004007 CHEBI:26020 ! has primary input or output [Term] id: GO:0006801 name: superoxide metabolic process namespace: biological_process def: "The chemical reactions and pathways involving superoxide, the superoxide anion O2- (superoxide free radical), or any compound containing this species." [GOC:jl] synonym: "oxygen free radical metabolic process" EXACT [] synonym: "oxygen free radical metabolism" EXACT [] synonym: "superoxide free radical metabolic process" EXACT [] synonym: "superoxide free radical metabolism" EXACT [] synonym: "superoxide metabolism" EXACT [] is_a: GO:0072593 ! reactive oxygen species metabolic process intersection_of: GO:0008152 ! metabolic process intersection_of: RO:0004007 CHEBI:18421 ! has primary input or output relationship: RO:0004007 CHEBI:18421 ! has primary input or output [Term] id: GO:0006809 name: nitric oxide biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of nitric oxide, nitrogen monoxide (NO), a colorless gas only slightly soluble in water." [GOC:ai] synonym: "nitric oxide anabolism" EXACT [] synonym: "nitric oxide biosynthesis" EXACT [] synonym: "nitric oxide formation" EXACT [] synonym: "nitric oxide synthesis" EXACT [] is_a: GO:0009058 ! biosynthetic process is_a: GO:0046209 ! nitric oxide metabolic process intersection_of: GO:0009058 ! biosynthetic process intersection_of: RO:0004008 CHEBI:16480 ! has primary output relationship: RO:0004008 CHEBI:16480 ! has primary output [Term] id: GO:0006810 name: transport namespace: biological_process def: "The directed movement of substances (such as macromolecules, small molecules, ions) or cellular components (such as complexes and organelles) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or a transporter complex, a pore or a motor protein." [GOC:dos, GOC:dph, GOC:jl, GOC:mah] comment: Note that this term should not be used for direct annotation. It should be possible to make a more specific annotation to one of the children of this term, for e.g. to transmembrane transport, to microtubule-based transport or to vesicle-mediated transport. subset: gocheck_do_not_annotate subset: goslim_candida subset: goslim_chembl subset: goslim_metagenomics subset: goslim_pir subset: goslim_plant subset: goslim_plant_ribbon subset: goslim_prokaryote subset: goslim_prokaryote_ribbon synonym: "single-organism transport" RELATED [] xref: Reactome:R-HSA-382551 "Transport of small molecules" is_a: GO:0051234 ! establishment of localization property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/20292" xsd:anyURI creation_date: 2012-12-13T16:25:32Z [Term] id: GO:0006811 name: monoatomic ion transport namespace: biological_process def: "The directed movement of a monoatomic ion into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Monatomic ions (also called simple ions) are ions consisting of exactly one atom." [GOC:ai] subset: goslim_drosophila subset: goslim_pir subset: goslim_yeast synonym: "ion transport" BROAD [] xref: Reactome:R-HSA-425393 "Transport of inorganic cations/anions and amino acids/oligopeptides" is_a: BFO:0000003 is_a: GO:0006810 ! transport intersection_of: GO:0006810 ! transport intersection_of: RO:0004009 CHEBI:24867 ! has primary input relationship: RO:0004009 CHEBI:24867 ! has primary input [Term] id: GO:0006812 name: monoatomic cation transport namespace: biological_process def: "The directed movement of a monoatomic cation, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Monatomic cations (also called simple cations) are positively charged ions consisting of exactly one atom." [GOC:ai] synonym: "cation transport" BROAD [] synonym: "di-, tri-valent inorganic cation transport" NARROW [GOC:mah] synonym: "trivalent inorganic cation transport" NARROW [] is_a: GO:0006811 ! monoatomic ion transport intersection_of: GO:0006810 ! transport intersection_of: RO:0004009 CHEBI:23906 ! has primary input relationship: RO:0004009 CHEBI:23906 ! has primary input [Term] id: GO:0006813 name: potassium ion transport namespace: biological_process def: "The directed movement of potassium ions (K+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] synonym: "cellular potassium ion transport" EXACT [] synonym: "K+ conductance" RELATED [] synonym: "low voltage-dependent potassium channel auxiliary protein activity" RELATED [GOC:mah] synonym: "low voltage-gated potassium channel auxiliary protein activity" RELATED [GOC:mah] synonym: "potassium conductance" NARROW [] synonym: "potassium ion conductance" NARROW [] synonym: "potassium transport" RELATED [] synonym: "sodium/potassium transport" BROAD [] is_a: GO:0030001 ! metal ion transport intersection_of: GO:0006810 ! transport intersection_of: RO:0004009 CHEBI:29103 ! has primary input relationship: RO:0004009 CHEBI:29103 ! has primary input creation_date: 2010-09-03T02:39:22Z [Term] id: GO:0006814 name: sodium ion transport namespace: biological_process def: "The directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] synonym: "mitochondrial sodium/calcium ion exchange" NARROW [] synonym: "sodium channel auxiliary protein activity" RELATED [GOC:mah] synonym: "sodium transport" EXACT [] synonym: "sodium/potassium transport" BROAD [] synonym: "sodium:calcium exchange" NARROW [] synonym: "sodium:solute transport" NARROW [] is_a: GO:0030001 ! metal ion transport intersection_of: GO:0006810 ! transport intersection_of: RO:0004009 CHEBI:29101 ! has primary input relationship: RO:0004009 CHEBI:29101 ! has primary input [Term] id: GO:0006816 name: calcium ion transport namespace: biological_process def: "The directed movement of calcium (Ca) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] synonym: "calcium transport" EXACT [] synonym: "mitochondrial sodium/calcium ion exchange" NARROW [] synonym: "sodium:calcium exchange" NARROW [] is_a: GO:0030001 ! metal ion transport intersection_of: GO:0006810 ! transport intersection_of: RO:0004009 CHEBI:29108 ! has primary input relationship: RO:0004009 CHEBI:29108 ! has primary input [Term] id: GO:0006817 name: phosphate ion transport namespace: biological_process def: "The directed movement of phosphate ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc] synonym: "phosphate transport" RELATED [] is_a: GO:0015698 ! inorganic anion transport intersection_of: GO:0006810 ! transport intersection_of: RO:0004009 CHEBI:43474 ! has primary input relationship: RO:0004009 CHEBI:43474 ! has primary input [Term] id: GO:0006826 name: iron ion transport namespace: biological_process def: "The directed movement of iron (Fe) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] synonym: "ferric ion import" NARROW [] synonym: "ferric ion transport" NARROW [] synonym: "ferric iron import" NARROW [] synonym: "ferric iron transport" NARROW [] synonym: "ferric iron uptake" NARROW [] synonym: "ferrous ion transport" NARROW [] synonym: "ferrous iron transport" NARROW [] synonym: "iron ion import" RELATED [] synonym: "iron transport" EXACT [] is_a: GO:0000041 ! transition metal ion transport intersection_of: GO:0006810 ! transport intersection_of: RO:0004009 CHEBI:24875 ! has primary input relationship: RO:0004009 CHEBI:24875 ! has primary input creation_date: 2012-04-18T03:33:45Z [Term] id: GO:0006833 name: water transport namespace: biological_process def: "The directed movement of water (H2O) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] xref: Reactome:R-HSA-445717 "Aquaporin-mediated transport" is_a: BFO:0000003 is_a: GO:0042044 ! fluid transport intersection_of: GO:0042044 ! fluid transport intersection_of: RO:0004009 CHEBI:15377 ! has primary input relationship: RO:0004009 CHEBI:15377 ! has primary input [Term] id: GO:0006835 name: dicarboxylic acid transport namespace: biological_process def: "The directed movement of dicarboxylic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc] synonym: "sodium:dicarboxylate transport" RELATED [] is_a: GO:0046942 ! carboxylic acid transport intersection_of: GO:0006810 ! transport intersection_of: RO:0004009 CHEBI:35693 ! has primary input relationship: RO:0004009 CHEBI:35693 ! has primary input [Term] id: GO:0006836 name: neurotransmitter transport namespace: biological_process def: "The directed movement of a neurotransmitter into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Neurotransmitters are any chemical substance that is capable of transmitting (or inhibiting the transmission of) a nerve impulse from a neuron to another cell." [GOC:ai] subset: goslim_pir synonym: "sodium:neurotransmitter transport" NARROW [] xref: Reactome:R-HSA-181429 "Serotonin Neurotransmitter Release Cycle" xref: Reactome:R-HSA-181430 "Norepinephrine Neurotransmitter Release Cycle" xref: Reactome:R-HSA-210500 "Glutamate Neurotransmitter Release Cycle" xref: Reactome:R-HSA-212676 "Dopamine Neurotransmitter Release Cycle" xref: Reactome:R-HSA-264642 "Acetylcholine Neurotransmitter Release Cycle" is_a: GO:0006810 ! transport relationship: RO:0002162 NCBITaxon:33208 ! in taxon Metazoa [Term] id: GO:0006837 name: serotonin transport namespace: biological_process def: "The directed movement of serotonin into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Serotonin (5-hydroxytryptamine) is a monoamine neurotransmitter occurring in the peripheral and central nervous systems." [GOC:ai] is_a: GO:0015844 ! monoamine transport is_a: GO:0015850 ! organic hydroxy compound transport intersection_of: GO:0006810 ! transport intersection_of: RO:0004009 CHEBI:350546 ! has primary input relationship: RO:0004009 CHEBI:350546 ! has primary input [Term] id: GO:0006839 name: mitochondrial transport namespace: biological_process def: "Transport of substances into, out of or within a mitochondrion." [GOC:ai] subset: goslim_drosophila is_a: GO:0046907 ! intracellular transport intersection_of: GO:0046907 ! intracellular transport intersection_of: RO:0002344 GO:0005739 ! results in transport to from or in mitochondrion relationship: RO:0002344 GO:0005739 ! results in transport to from or in mitochondrion property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/22316" xsd:anyURI [Term] id: GO:0006851 name: mitochondrial calcium ion transmembrane transport namespace: biological_process def: "The process in which a calcium ion (Ca2+) is transported across a mitochondrial membrane, into or out of the mitochondrion." [GOC:ai] synonym: "mitochondrial calcium transport" EXACT [] xref: Reactome:R-HSA-8949215 "Mitochondrial calcium ion transport" is_a: GO:0070588 ! calcium ion transmembrane transport intersection_of: GO:0006810 ! transport intersection_of: RO:0002342 GO:0031966 ! results in transport across mitochondrial membrane intersection_of: RO:0004009 CHEBI:29108 ! has primary input relationship: RO:0002342 GO:0031966 ! results in transport across mitochondrial membrane [Term] id: GO:0006858 name: extracellular transport namespace: biological_process def: "The transport of substances that occurs outside cells." [GOC:go_curators] is_a: BFO:0000003 is_a: GO:0006810 ! transport intersection_of: GO:0006810 ! transport intersection_of: BFO:0000066 GO:0005576 ! occurs in extracellular region relationship: BFO:0000066 GO:0005576 ! occurs in extracellular region [Term] id: GO:0006860 name: extracellular amino acid transport namespace: biological_process def: "The directed extracellular movement of amino acids." [GOC:ai] is_a: GO:0006858 ! extracellular transport is_a: GO:0006865 ! amino acid transport intersection_of: GO:0006865 ! amino acid transport intersection_of: BFO:0000066 GO:0005576 ! occurs in extracellular region [Term] id: GO:0006862 name: nucleotide transport namespace: biological_process def: "The directed movement of a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate, into, out of or within a cell." [ISBN:0198506732] is_a: GO:0015748 ! organophosphate ester transport is_a: GO:0015931 ! nucleobase-containing compound transport intersection_of: GO:0006810 ! transport intersection_of: RO:0004009 CHEBI:36976 ! has primary input relationship: RO:0004009 CHEBI:36976 ! has primary input [Term] id: GO:0006865 name: amino acid transport namespace: biological_process def: "The directed movement of amino acids, organic acids containing one or more amino substituents, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] subset: goslim_pir subset: goslim_yeast xref: Reactome:R-HSA-352230 "Amino acid transport across the plasma membrane" is_a: BFO:0000003 is_a: GO:0006810 ! transport intersection_of: GO:0006810 ! transport intersection_of: RO:0004009 CHEBI:35238 ! has primary input relationship: RO:0004009 CHEBI:35238 ! has primary input [Term] id: GO:0006869 name: lipid transport namespace: biological_process def: "The directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Lipids are compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent." [ISBN:0198506732] subset: goslim_drosophila subset: goslim_pir subset: goslim_yeast xref: Reactome:R-HSA-1369062 "ABC transporters in lipid homeostasis" is_a: BFO:0000003 is_a: GO:0006810 ! transport intersection_of: GO:0006810 ! transport intersection_of: RO:0004009 CHEBI:18059 ! has primary input relationship: BFO:0000050 GO:0010876 ! part of lipid localization relationship: RO:0004009 CHEBI:18059 ! has primary input [Term] id: GO:0006873 name: intracellular monoatomic ion homeostasis namespace: biological_process def: "A homeostatic process involved in the maintenance of a steady state level of monoatomic ions within a cell. Monatomic ions (also called simple ions) are ions consisting of exactly one atom." [GOC:mah] subset: goslim_yeast synonym: "cellular ion homeostasis" BROAD [] synonym: "cellular monoatomic ion homeostasis" EXACT [] is_a: GO:0050801 ! monoatomic ion homeostasis is_a: GO:0055082 ! intracellular chemical homeostasis intersection_of: GO:0019725 ! cellular homeostasis intersection_of: RO:0002332 CHEBI:24867 ! regulates levels of property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/24455" xsd:anyURI [Term] id: GO:0006874 name: intracellular calcium ion homeostasis namespace: biological_process def: "A homeostatic process involved in the maintenance of a steady state level of calcium ions within a cell." [GOC:ceb, GOC:mah] synonym: "cellular calcium ion homeostasis" EXACT [] synonym: "regulation of calcium ion concentration" BROAD [] is_a: GO:0030003 ! intracellular monoatomic cation homeostasis is_a: GO:0055074 ! calcium ion homeostasis intersection_of: GO:0019725 ! cellular homeostasis intersection_of: RO:0002332 CHEBI:29108 ! regulates levels of [Term] id: GO:0006879 name: intracellular iron ion homeostasis namespace: biological_process def: "A homeostatic process involved in the maintenance of a steady state level of iron ions within a cell." [GOC:ai, GOC:mah] synonym: "cellular iron ion homeostasis" EXACT [] synonym: "iron homeostasis" BROAD [] xref: Reactome:R-HSA-917937 "Iron uptake and transport" is_a: GO:0030003 ! intracellular monoatomic cation homeostasis is_a: GO:0098771 ! inorganic ion homeostasis intersection_of: GO:0055082 ! intracellular chemical homeostasis intersection_of: RO:0002332 CHEBI:24875 ! regulates levels of relationship: RO:0002332 CHEBI:24875 ! regulates levels of [Term] id: GO:0006883 name: intracellular sodium ion homeostasis namespace: biological_process def: "A homeostatic process involved in the maintenance of a steady state level of sodium ions within a cell." [GOC:ai, GOC:mah] synonym: "cellular sodium ion homeostasis" EXACT [] is_a: GO:0030003 ! intracellular monoatomic cation homeostasis is_a: GO:0055078 ! sodium ion homeostasis intersection_of: GO:0055082 ! intracellular chemical homeostasis intersection_of: RO:0002332 CHEBI:29101 ! regulates levels of [Term] id: GO:0006884 name: cell volume homeostasis namespace: biological_process def: "Any process involved in maintaining the steady state of a cell's volume. The cell's volume refers to the three-dimensional space occupied by a cell." [GOC:dph, GOC:go_curators, GOC:tb] synonym: "regulation of cell volume" EXACT [GOC:dph, GOC:tb] is_a: GO:0008361 ! regulation of cell size is_a: GO:0019725 ! cellular homeostasis [Term] id: GO:0006886 name: intracellular protein transport namespace: biological_process def: "The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah] subset: goslim_generic subset: goslim_prokaryote synonym: "copper-induced intracellular protein transport" RELATED [GOC:al] is_a: GO:0015031 ! protein transport is_a: GO:0046907 ! intracellular transport intersection_of: GO:0046907 ! intracellular transport intersection_of: RO:0004009 PR:000000001 ! has primary input protein relationship: BFO:0000050 GO:0008104 ! part of intracellular protein localization [Term] id: GO:0006887 name: exocytosis namespace: biological_process def: "A process of secretion by a cell that results in the release of intracellular molecules (e.g. hormones, matrix proteins) contained within a membrane-bounded vesicle. Exocytosis can occur either by full fusion, when the vesicle collapses into the plasma membrane, or by a kiss-and-run mechanism that involves the formation of a transient contact, a pore, between a granule (for example of chromaffin cells) and the plasma membrane. The latter process most of the time leads to only partial secretion of the granule content. Exocytosis begins with steps that prepare vesicles for fusion with the membrane (tethering and docking) and ends when molecules are secreted from the cell." [GOC:mah, ISBN:0716731363, PMID:22323285] subset: goslim_yeast synonym: "nonselective vesicle exocytosis" RELATED [] synonym: "vesicle exocytosis" EXACT [] xref: Wikipedia:Exocytosis is_a: BFO:0000003 is_a: GO:0016192 ! vesicle-mediated transport is_a: GO:0032940 ! secretion by cell intersection_of: GO:0016192 ! vesicle-mediated transport intersection_of: RO:0002608 GO:0070382 ! process has causal agent exocytic vesicle relationship: BFO:0000051 GO:0099500 ! has part vesicle fusion to plasma membrane relationship: RO:0002608 GO:0070382 ! process has causal agent exocytic vesicle [Term] id: GO:0006892 name: post-Golgi vesicle-mediated transport namespace: biological_process def: "The directed movement of substances from the Golgi to other parts of the cell, including organelles and the plasma membrane, mediated by small transport vesicles." [GOC:ai, GOC:mah] synonym: "post-Golgi transport" EXACT [] xref: Reactome:R-HSA-199992 "trans-Golgi Network Vesicle Budding" is_a: GO:0048193 ! Golgi vesicle transport [Term] id: GO:0006893 name: Golgi to plasma membrane transport namespace: biological_process def: "The directed movement of substances from the Golgi to the plasma membrane in transport vesicles that move from the trans-Golgi network to the plasma membrane, where they fuse and release their contents by exocytosis." [ISBN:0716731363] synonym: "Golgi to plasma membrane vesicle-mediated transport" EXACT [] is_a: GO:0006892 ! post-Golgi vesicle-mediated transport is_a: GO:0098876 ! vesicle-mediated transport to the plasma membrane intersection_of: GO:0016192 ! vesicle-mediated transport intersection_of: RO:0002338 GO:0005794 ! has target start location Golgi apparatus intersection_of: RO:0002339 GO:0005886 ! has target end location plasma membrane relationship: RO:0002338 GO:0005794 ! has target start location Golgi apparatus [Term] id: GO:0006896 name: Golgi to vacuole transport namespace: biological_process def: "The directed movement of substances from the Golgi to the vacuole." [GOC:ai] synonym: "Golgi to vacuole vesicle-mediated transport" EXACT [] is_a: GO:0006892 ! post-Golgi vesicle-mediated transport is_a: GO:0007034 ! vacuolar transport intersection_of: GO:0016192 ! vesicle-mediated transport intersection_of: BFO:0000066 GO:0005622 ! occurs in intracellular anatomical structure intersection_of: RO:0002338 GO:0005794 ! has target start location Golgi apparatus intersection_of: RO:0002339 GO:0005773 ! has target end location vacuole relationship: RO:0002338 GO:0005794 ! has target start location Golgi apparatus relationship: RO:0002339 GO:0005773 ! has target end location vacuole [Term] id: GO:0006897 name: endocytosis namespace: biological_process def: "A vesicle-mediated transport process in which cells take up external materials or membrane constituents by the invagination of a part of the plasma membrane to form a new membrane-bounded vesicle." [GOC:mah, ISBN:0198506732, ISBN:0716731363, Wikipedia:Endocytosis] subset: goslim_yeast synonym: "endocytic import into cell" EXACT [] synonym: "nonselective vesicle endocytosis" RELATED [] synonym: "plasma membrane invagination" NARROW [] synonym: "vesicle endocytosis" EXACT [] xref: Wikipedia:Endocytosis is_a: GO:0016192 ! vesicle-mediated transport is_a: GO:0098657 ! import into cell relationship: BFO:0000051 GO:0006900 ! has part vesicle budding from membrane relationship: BFO:0000051 GO:0010324 ! has part membrane invagination relationship: RO:0002339 GO:0031410 ! has target end location cytoplasmic vesicle property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/24907" xsd:anyURI property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/25268" xsd:anyURI [Term] id: GO:0006900 name: vesicle budding from membrane namespace: biological_process def: "The evagination of a membrane, resulting in formation of a vesicle." [GOC:jid, GOC:tb] synonym: "membrane evagination" EXACT [] synonym: "nonselective vesicle assembly" RELATED [] synonym: "single organism membrane budding" RELATED [GOC:TermGenie] synonym: "single-organism membrane budding" RELATED [] synonym: "vesicle biosynthesis" EXACT [] synonym: "vesicle budding" RELATED [] synonym: "vesicle formation" EXACT [] is_a: GO:0016050 ! vesicle organization is_a: GO:0061024 ! membrane organization relationship: BFO:0000050 GO:0016192 ! part of vesicle-mediated transport creation_date: 2013-12-19T15:26:17Z [Term] id: GO:0006903 name: vesicle targeting namespace: biological_process def: "The process in which vesicles are directed to specific destination membranes. Targeting involves coordinated interactions among cytoskeletal elements (microtubules or actin filaments), motor proteins, molecules at the vesicle membrane and target membrane surfaces, and vesicle cargo." [GOC:mah, PMID:17335816] is_a: BFO:0000003 is_a: GO:0009987 ! cellular process relationship: BFO:0000050 GO:0016192 ! part of vesicle-mediated transport relationship: BFO:0000050 GO:0051650 ! part of establishment of vesicle localization [Term] id: GO:0006906 name: vesicle fusion namespace: biological_process def: "Fusion of the membrane of a transport vesicle with its target membrane." [GOC:jid] is_a: GO:0016050 ! vesicle organization is_a: GO:0090174 ! organelle membrane fusion intersection_of: GO:0009987 ! cellular process intersection_of: RO:0012008 GO:0012506 ! results in fusion of vesicle membrane relationship: BFO:0000050 GO:0016192 ! part of vesicle-mediated transport relationship: RO:0012008 GO:0012506 ! results in fusion of vesicle membrane [Term] id: GO:0006909 name: phagocytosis namespace: biological_process def: "A vesicle-mediated transport process that results in the engulfment of external particulate material by phagocytes and their delivery to the lysosome. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles." [ISBN:0198506732] xref: Reactome:R-HSA-9664417 "Leishmania phagocytosis" xref: Wikipedia:Phagocytosis is_a: GO:0006897 ! endocytosis property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/24907" xsd:anyURI property_value: RO:0002161 NCBITaxon:4751 [Term] id: GO:0006913 name: nucleocytoplasmic transport namespace: biological_process def: "The directed movement of molecules between the nucleus and the cytoplasm." [GOC:go_curators] comment: Note that transport through the nuclear pore complex is not transmembrane because the nuclear membrane is a double membrane, and is not traversed. subset: goslim_chembl subset: goslim_drosophila subset: goslim_generic subset: goslim_pombe synonym: "nucleocytoplasmic shuttling" NARROW [] is_a: GO:0051169 ! nuclear transport intersection_of: GO:0006810 ! transport intersection_of: RO:0002342 GO:0005635 ! results in transport across nuclear envelope intersection_of: RO:0002344 GO:0005829 ! results in transport to from or in cytosol intersection_of: RO:0002344 GO:0031981 ! results in transport to from or in nuclear lumen relationship: RO:0002342 GO:0005635 ! results in transport across nuclear envelope relationship: RO:0002344 GO:0005829 ! results in transport to from or in cytosol relationship: RO:0002344 GO:0031981 ! results in transport to from or in nuclear lumen [Term] id: GO:0006915 name: apoptotic process namespace: biological_process def: "A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died." [GOC:cjm, GOC:dhl, GOC:ecd, GOC:go_curators, GOC:mtg_apoptosis, GOC:tb, ISBN:0198506732, PMID:18846107, PMID:21494263] synonym: "activation of apoptosis" NARROW [] synonym: "apoptosis" NARROW [] synonym: "apoptosis activator activity" RELATED [] synonym: "apoptosis signaling" NARROW [] synonym: "apoptotic cell death" EXACT [GOC:sl] synonym: "apoptotic program" NARROW [GOC:add] synonym: "apoptotic programmed cell death" EXACT [] synonym: "caspase-dependent programmed cell death" RELATED [] synonym: "cell suicide" BROAD [] synonym: "cellular suicide" BROAD [] synonym: "commitment to apoptosis" RELATED [] synonym: "induction of apoptosis" RELATED [] synonym: "induction of apoptosis by p53" RELATED [] synonym: "programmed cell death by apoptosis" EXACT [] synonym: "signaling (initiator) caspase activity" RELATED [] synonym: "type I programmed cell death" NARROW [] xref: Reactome:R-HSA-109581 "Apoptosis" xref: Wikipedia:Apoptosis is_a: GO:0012501 ! programmed cell death relationship: RO:0002224 GO:0097190 ! starts with apoptotic signaling pathway relationship: RO:0002230 GO:0097194 ! ends with execution phase of apoptosis property_value: RO:0002161 NCBITaxon:4896 [Term] id: GO:0006921 name: cellular component disassembly involved in execution phase of apoptosis namespace: biological_process def: "The breakdown of structures such as organelles, proteins, or other macromolecular structures during apoptosis." [GOC:dph, GOC:mah, GOC:mtg_apoptosis, GOC:tb] synonym: "cellular component disassembly involved in apoptosis" NARROW [] synonym: "cellular component disassembly involved in apoptotic process" BROAD [] synonym: "disassembly of cell structures" BROAD [] is_a: GO:0022411 ! cellular component disassembly intersection_of: GO:0022411 ! cellular component disassembly intersection_of: BFO:0000050 GO:0097194 ! part of execution phase of apoptosis relationship: BFO:0000050 GO:0097194 ! part of execution phase of apoptosis property_value: RO:0002161 NCBITaxon:4896 [Term] id: GO:0006925 name: inflammatory cell apoptotic process namespace: biological_process def: "Any apoptotic process in an inflammatory cell, any cell participating in the inflammatory response to a foreign substance e.g. neutrophil, macrophage." [GOC:jl, GOC:mtg_apoptosis] synonym: "apoptosis of inflammatory cells" EXACT [] synonym: "inflammatory cell apoptosis" NARROW [] synonym: "inflammatory cell programmed cell death by apoptosis" EXACT [] synonym: "killing of inflammatory cells" EXACT [] synonym: "programmed cell death of inflammatory cells by apoptosis" EXACT [] synonym: "programmed cell death, inflammatory cells" EXACT [] xref: Reactome:R-HSA-168277 "Influenza Virus Induced Apoptosis" is_a: GO:0006915 ! apoptotic process property_value: RO:0002161 NCBITaxon:4896 [Term] id: GO:0006935 name: chemotaxis namespace: biological_process def: "The directed movement of a motile cell or organism, or the directed growth of a cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis)." [ISBN:0198506732] synonym: "taxis in response to chemical stimulus" EXACT [] xref: Wikipedia:Chemotaxis is_a: GO:0042330 ! taxis relationship: BFO:0000050 GO:0042221 ! part of response to chemical property_value: RO:0002161 NCBITaxon:451864 [Term] id: GO:0006936 name: muscle contraction namespace: biological_process def: "A process in which force is generated within muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis." [GOC:ef, GOC:mtg_muscle, ISBN:0198506732] subset: goslim_pir xref: Reactome:R-HSA-445355 "Smooth Muscle Contraction" xref: Wikipedia:Muscle_contraction is_a: BFO:0000003 is_a: GO:0003012 ! muscle system process relationship: BFO:0000066 UBERON:0002385 ! occurs in muscle tissue property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0006937 name: regulation of muscle contraction namespace: biological_process def: "Any process that modulates the frequency, rate or extent of muscle contraction." [GOC:go_curators] is_a: GO:0090257 ! regulation of muscle system process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0006936 ! regulates muscle contraction relationship: RO:0002211 GO:0006936 ! regulates muscle contraction property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0006939 name: smooth muscle contraction namespace: biological_process def: "A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. Smooth muscle differs from striated muscle in the much higher actin/myosin ratio, the absence of conspicuous sarcomeres and the ability to contract to a much smaller fraction of its resting length." [GOC:ef, GOC:jl, GOC:mtg_muscle, ISBN:0198506732] synonym: "visceral muscle contraction" EXACT [] is_a: GO:0006936 ! muscle contraction intersection_of: GO:0006936 ! muscle contraction intersection_of: BFO:0000066 UBERON:0001135 ! occurs in smooth muscle tissue relationship: BFO:0000066 UBERON:0001135 ! occurs in smooth muscle tissue property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0006940 name: regulation of smooth muscle contraction namespace: biological_process def: "Any process that modulates the frequency, rate or extent of smooth muscle contraction." [GOC:go_curators] is_a: GO:0006937 ! regulation of muscle contraction intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0006939 ! regulates smooth muscle contraction relationship: RO:0002211 GO:0006939 ! regulates smooth muscle contraction property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0006941 name: striated muscle contraction namespace: biological_process def: "A process in which force is generated within striated muscle tissue, resulting in the shortening of the muscle. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. Striated muscle is a type of muscle in which the repeating units (sarcomeres) of the contractile myofibrils are arranged in registry throughout the cell, resulting in transverse or oblique striations observable at the level of the light microscope." [GOC:jl, GOC:mtg_muscle, ISBN:0198506732] synonym: "sarcomeric muscle contraction" EXACT [] is_a: GO:0006936 ! muscle contraction relationship: BFO:0000066 UBERON:0002036 ! occurs in striated muscle tissue property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0006942 name: regulation of striated muscle contraction namespace: biological_process def: "Any process that modulates the frequency, rate or extent of striated muscle contraction." [GOC:go_curators] is_a: GO:0006937 ! regulation of muscle contraction intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0006941 ! regulates striated muscle contraction relationship: RO:0002211 GO:0006941 ! regulates striated muscle contraction property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0006949 name: syncytium formation namespace: biological_process def: "The formation of a syncytium, a mass of cytoplasm containing several nuclei enclosed within a single plasma membrane. Syncytia are normally derived from single cells that fuse or fail to complete cell division." [ISBN:0198506732] subset: goslim_pir is_a: BFO:0000003 is_a: GO:0009987 ! cellular process is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 CL:0000228 ! results in formation of anatomical entity multinucleate cell relationship: RO:0002297 CL:0000228 ! results in formation of anatomical entity multinucleate cell [Term] id: GO:0006950 name: response to stress namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:mah] subset: goslim_candida subset: goslim_chembl subset: goslim_drosophila subset: goslim_metagenomics subset: goslim_plant subset: goslim_plant_ribbon synonym: "response to abiotic stress" RELATED [] synonym: "response to biotic stress" RELATED [] is_a: GO:0050896 ! response to stimulus property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/26810" xsd:anyURI [Term] id: GO:0006952 name: defense response namespace: biological_process def: "Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack." [GOC:go_curators] synonym: "antimicrobial peptide activity" RELATED [] synonym: "defence response" EXACT [] synonym: "defense/immunity protein activity" RELATED [] synonym: "physiological defense response" EXACT [] is_a: GO:0006950 ! response to stress [Term] id: GO:0006954 name: inflammatory response namespace: biological_process def: "The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages." [GO_REF:0000022, ISBN:0198506732] subset: goslim_generic synonym: "inflammation" BROAD [] xref: Wikipedia:Inflammation is_a: GO:0006952 ! defense response relationship: RO:0002162 NCBITaxon:7742 ! in taxon Vertebrata [Term] id: GO:0006955 name: immune response namespace: biological_process def: "Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat." [GO_REF:0000022, GOC:add] subset: goslim_drosophila is_a: GO:0002376 ! immune system process is_a: GO:0050896 ! response to stimulus property_value: RO:0002161 NCBITaxon:4895 [Term] id: GO:0006959 name: humoral immune response namespace: biological_process def: "An immune response mediated through a body fluid." [GOC:hb, ISBN:0198506732] xref: Wikipedia:Humoral_immunity is_a: GO:0006955 ! immune response property_value: RO:0002161 NCBITaxon:4895 [Term] id: GO:0006979 name: response to oxidative stress namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals." [GOC:jl, PMID:12115731] subset: goslim_yeast is_a: GO:0006950 ! response to stress [Term] id: GO:0006996 name: organelle organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an organelle within a cell. An organelle is an organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane." [GOC:mah] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_annotate subset: goslim_candida subset: goslim_pir synonym: "organelle organisation" EXACT [] synonym: "organelle organization and biogenesis" RELATED [GOC:dph, GOC:jl, GOC:mah] synonym: "single organism organelle organization" EXACT [GOC:TermGenie] synonym: "single-organism organelle organization" RELATED [] xref: Reactome:R-HSA-1852241 "Organelle biogenesis and maintenance" is_a: GO:0016043 ! cellular component organization intersection_of: GO:0016043 ! cellular component organization intersection_of: RO:0002592 GO:0043226 ! results in organization of organelle relationship: RO:0002592 GO:0043226 ! results in organization of organelle property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/27189" xsd:anyURI creation_date: 2013-12-19T15:25:51Z [Term] id: GO:0006997 name: nucleus organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nucleus." [GOC:dph, GOC:ems, GOC:jl, GOC:mah] subset: goslim_candida subset: goslim_drosophila subset: goslim_pir subset: goslim_yeast synonym: "nuclear morphology" RELATED [] synonym: "nuclear organisation" EXACT [] synonym: "nuclear organization" EXACT [] synonym: "nuclear organization and biogenesis" RELATED [GOC:mah] synonym: "nucleus organization and biogenesis" RELATED [GOC:mah] is_a: GO:0006996 ! organelle organization intersection_of: GO:0016043 ! cellular component organization intersection_of: RO:0002592 GO:0005634 ! results in organization of nucleus relationship: RO:0002592 GO:0005634 ! results in organization of nucleus [Term] id: GO:0006998 name: nuclear envelope organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nuclear envelope." [GOC:dph, GOC:ems, GOC:jl, GOC:mah] synonym: "nuclear envelope organisation" EXACT [GOC:mah] synonym: "nuclear envelope organization and biogenesis" RELATED [GOC:mah] is_a: GO:0061024 ! membrane organization intersection_of: GO:0016043 ! cellular component organization intersection_of: RO:0002592 GO:0005635 ! results in organization of nuclear envelope relationship: BFO:0000050 GO:0006997 ! part of nucleus organization relationship: BFO:0000050 GO:0010256 ! part of endomembrane system organization relationship: RO:0002592 GO:0005635 ! results in organization of nuclear envelope [Term] id: GO:0007000 name: nucleolus organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nucleolus." [GOC:dph, GOC:jid, GOC:jl, GOC:mah] synonym: "nucleolus organisation" EXACT [] synonym: "nucleolus organization and biogenesis" RELATED [GOC:mah] is_a: GO:0006997 ! nucleus organization intersection_of: GO:0016043 ! cellular component organization intersection_of: RO:0002592 GO:0005730 ! results in organization of nucleolus relationship: RO:0002592 GO:0005730 ! results in organization of nucleolus [Term] id: GO:0007005 name: mitochondrion organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a mitochondrion; includes mitochondrial morphogenesis and distribution, and replication of the mitochondrial genome as well as synthesis of new mitochondrial components." [GOC:dph, GOC:jl, GOC:mah, GOC:sgd_curators, PMID:9786946] subset: goslim_chembl subset: goslim_drosophila subset: goslim_generic subset: goslim_pir subset: goslim_pombe subset: goslim_yeast synonym: "mitochondria organization" EXACT [GOC:mah] synonym: "mitochondrial biogenesis" EXACT [] synonym: "mitochondrial organization" EXACT [] synonym: "mitochondrion biogenesis" EXACT [] synonym: "mitochondrion morphogenesis" RELATED [] synonym: "mitochondrion organisation" EXACT [GOC:mah] synonym: "mitochondrion organization and biogenesis" RELATED [] xref: Reactome:R-HSA-1592230 "Mitochondrial biogenesis" is_a: GO:0006996 ! organelle organization intersection_of: GO:0016043 ! cellular component organization intersection_of: RO:0002592 GO:0005739 ! results in organization of mitochondrion relationship: RO:0002592 GO:0005739 ! results in organization of mitochondrion [Term] id: GO:0007006 name: mitochondrial membrane organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a mitochondrial membrane, either of the lipid bilayer surrounding a mitochondrion." [GOC:ai, GOC:dph, GOC:jl, GOC:mah] synonym: "mitochondrial membrane organisation" EXACT [] synonym: "mitochondrial membrane organization and biogenesis" RELATED [GOC:mah] is_a: GO:0007005 ! mitochondrion organization is_a: GO:0061024 ! membrane organization intersection_of: GO:0061024 ! membrane organization intersection_of: BFO:0000066 GO:0005739 ! occurs in mitochondrion relationship: BFO:0000066 GO:0005739 ! occurs in mitochondrion relationship: RO:0002162 NCBITaxon:2759 ! in taxon Eukaryota [Term] id: GO:0007008 name: outer mitochondrial membrane organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the mitochondrial outer membrane." [GOC:ai, GOC:dph, GOC:jl, GOC:mah] comment: See also the cellular component term 'mitochondrial outer membrane ; GO:0005741'. synonym: "outer mitochondrial membrane organisation" EXACT [] synonym: "outer mitochondrial membrane organization and biogenesis" RELATED [GOC:mah] is_a: GO:0007006 ! mitochondrial membrane organization intersection_of: GO:0016043 ! cellular component organization intersection_of: RO:0002592 GO:0005741 ! results in organization of mitochondrial outer membrane relationship: RO:0002592 GO:0005741 ! results in organization of mitochondrial outer membrane [Term] id: GO:0007009 name: plasma membrane organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the plasma membrane." [GOC:dph, GOC:jl, GOC:mah] subset: goslim_chembl synonym: "plasma membrane organisation" EXACT [] synonym: "plasma membrane organization and biogenesis" RELATED [GOC:mah] is_a: GO:0061024 ! membrane organization intersection_of: GO:0016043 ! cellular component organization intersection_of: RO:0002592 GO:0005886 ! results in organization of plasma membrane relationship: BFO:0000050 GO:0010256 ! part of endomembrane system organization relationship: RO:0002592 GO:0005886 ! results in organization of plasma membrane [Term] id: GO:0007010 name: cytoskeleton organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures." [GOC:dph, GOC:jl, GOC:mah] subset: goslim_candida subset: goslim_chembl subset: goslim_drosophila subset: goslim_generic subset: goslim_prokaryote subset: goslim_yeast synonym: "cytoskeletal organization and biogenesis" RELATED [GOC:mah] synonym: "cytoskeletal regulator activity" RELATED [] synonym: "cytoskeleton organisation" EXACT [] synonym: "cytoskeleton organization and biogenesis" RELATED [GOC:mah] is_a: GO:0006996 ! organelle organization intersection_of: GO:0016043 ! cellular component organization intersection_of: RO:0002592 GO:0005856 ! results in organization of cytoskeleton relationship: RO:0002592 GO:0005856 ! results in organization of cytoskeleton [Term] id: GO:0007015 name: actin filament organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments. Includes processes that control the spatial distribution of actin filaments, such as organizing filaments into meshworks, bundles, or other structures, as by cross-linking." [GOC:mah] synonym: "actin filament organisation" EXACT [] synonym: "regulation of actin filament localization" NARROW [] is_a: GO:0097435 ! supramolecular fiber organization intersection_of: GO:0016043 ! cellular component organization intersection_of: RO:0002592 GO:0005884 ! results in organization of actin filament relationship: BFO:0000050 GO:0030036 ! part of actin cytoskeleton organization relationship: RO:0002592 GO:0005884 ! results in organization of actin filament [Term] id: GO:0007017 name: microtubule-based process namespace: biological_process def: "Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins." [GOC:mah] subset: goslim_chembl is_a: GO:0009987 ! cellular process intersection_of: GO:0009987 ! cellular process intersection_of: RO:0002608 GO:0005874 ! process has causal agent microtubule relationship: RO:0002608 GO:0005874 ! process has causal agent microtubule property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/19809" xsd:anyURI [Term] id: GO:0007018 name: microtubule-based movement namespace: biological_process def: "A microtubule-based process that results in the movement of organelles, other microtubules, or other cellular components. Examples include motor-driven movement along microtubules and movement driven by polymerization or depolymerization of microtubules." [GOC:cjm, ISBN:0815316194] subset: goslim_drosophila subset: goslim_generic xref: Reactome:R-HSA-983189 "Kinesins" is_a: GO:0007017 ! microtubule-based process [Term] id: GO:0007019 name: microtubule depolymerization namespace: biological_process def: "The removal of tubulin heterodimers from one or both ends of a microtubule." [ISBN:0815316194] synonym: "microtubule catastrophe" NARROW [GOC:dph, GOC:tb] synonym: "microtubule depolymerization during nuclear congression" NARROW [] synonym: "microtubule disassembly" EXACT [] synonym: "microtubule shortening" EXACT [] is_a: GO:0031109 ! microtubule polymerization or depolymerization is_a: GO:0051261 ! protein depolymerization is_a: GO:0097435 ! supramolecular fiber organization intersection_of: GO:0022411 ! cellular component disassembly intersection_of: RO:0002590 GO:0005874 ! results in disassembly of microtubule relationship: RO:0002590 GO:0005874 ! results in disassembly of microtubule [Term] id: GO:0007020 name: microtubule nucleation namespace: biological_process def: "The process in which tubulin alpha-beta heterodimers begin aggregation to form an oligomeric tubulin structure (a microtubule seed). Microtubule nucleation is the initiating step in the formation of a microtubule in the absence of any existing microtubules ('de novo' microtubule formation)." [GOC:go_curators, ISBN:0815316194, PMID:12517712] xref: Wikipedia:Microtubule_nucleation is_a: GO:0000226 ! microtubule cytoskeleton organization relationship: BFO:0000050 GO:0046785 ! part of microtubule polymerization [Term] id: GO:0007026 name: negative regulation of microtubule depolymerization namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of microtubule depolymerization; prevention of depolymerization of a microtubule can result from binding by 'capping' at the plus end (e.g. by interaction with another cellular protein of structure) or by exposing microtubules to a stabilizing drug such as taxol." [GOC:mah, ISBN:0815316194] synonym: "down regulation of microtubule depolymerization" EXACT [] synonym: "down-regulation of microtubule depolymerization" EXACT [] synonym: "downregulation of microtubule depolymerization" EXACT [] synonym: "inhibition of microtubule depolymerization" NARROW [] synonym: "microtubule rescue" NARROW [GOC:dph, GOC:tb] synonym: "microtubule stabilization" EXACT [] synonym: "negative regulation of microtubule catastrophe" NARROW [GOC:dph, GOC:tb] synonym: "negative regulation of microtubule disassembly" EXACT [] is_a: GO:0031111 ! negative regulation of microtubule polymerization or depolymerization is_a: GO:0031114 ! regulation of microtubule depolymerization is_a: GO:1901880 ! negative regulation of protein depolymerization is_a: GO:1902904 ! negative regulation of supramolecular fiber organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0007019 ! negatively regulates microtubule depolymerization relationship: RO:0002212 GO:0007019 ! negatively regulates microtubule depolymerization [Term] id: GO:0007027 name: negative regulation of axonemal microtubule depolymerization namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the depolymerization of the specialized microtubules of the axoneme." [GOC:dph, GOC:mah] synonym: "axonemal microtubule stabilization" EXACT [] synonym: "negative regulation of microtubule depolymerization in axoneme" RELATED [GOC:dph] is_a: GO:0007026 ! negative regulation of microtubule depolymerization is_a: GO:0010937 ! regulation of cytoplasmic microtubule depolymerization is_a: GO:0031345 ! negative regulation of cell projection organization is_a: GO:0120035 ! regulation of plasma membrane bounded cell projection organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0060404 ! negatively regulates axonemal microtubule depolymerization relationship: RO:0002212 GO:0060404 ! negatively regulates axonemal microtubule depolymerization [Term] id: GO:0007028 name: cytoplasm organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the cytoplasm. The cytoplasm is all of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [GOC:curators, GOC:dph, GOC:jl, GOC:mah] subset: goslim_pir synonym: "cytoplasm organisation" EXACT [] synonym: "cytoplasm organization and biogenesis" RELATED [GOC:mah] is_a: GO:0016043 ! cellular component organization intersection_of: GO:0016043 ! cellular component organization intersection_of: RO:0002592 GO:0005737 ! results in organization of cytoplasm relationship: RO:0002592 GO:0005737 ! results in organization of cytoplasm [Term] id: GO:0007030 name: Golgi organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the Golgi apparatus." [GOC:dph, GOC:jl, GOC:mah] subset: goslim_pir synonym: "Golgi apparatus organization" EXACT [] synonym: "Golgi organisation" EXACT [] synonym: "Golgi organization and biogenesis" RELATED [GOC:mah] is_a: GO:0006996 ! organelle organization intersection_of: GO:0016043 ! cellular component organization intersection_of: RO:0002592 GO:0005794 ! results in organization of Golgi apparatus relationship: BFO:0000050 GO:0010256 ! part of endomembrane system organization relationship: RO:0002592 GO:0005794 ! results in organization of Golgi apparatus [Term] id: GO:0007033 name: vacuole organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a vacuole." [GOC:mah] subset: goslim_drosophila subset: goslim_pir subset: goslim_yeast synonym: "vacuolar assembly" NARROW [GOC:mah] synonym: "vacuole biogenesis" RELATED [GOC:mah] synonym: "vacuole organisation" EXACT [] synonym: "vacuole organization and biogenesis" RELATED [GOC:mah] is_a: GO:0006996 ! organelle organization intersection_of: GO:0016043 ! cellular component organization intersection_of: RO:0002592 GO:0005773 ! results in organization of vacuole relationship: RO:0002592 GO:0005773 ! results in organization of vacuole [Term] id: GO:0007034 name: vacuolar transport namespace: biological_process def: "The directed movement of substances into, out of or within a vacuole." [GOC:ai] subset: goslim_chembl is_a: GO:0046907 ! intracellular transport intersection_of: GO:0046907 ! intracellular transport intersection_of: RO:0002344 GO:0005773 ! results in transport to from or in vacuole relationship: RO:0002344 GO:0005773 ! results in transport to from or in vacuole [Term] id: GO:0007036 name: vacuolar calcium ion homeostasis namespace: biological_process def: "Any process involved in the maintenance of an internal steady state of calcium ions in the vacuole or between a vacuole and its surroundings." [GOC:ai, GOC:mah] is_a: GO:0006874 ! intracellular calcium ion homeostasis intersection_of: GO:0055074 ! calcium ion homeostasis intersection_of: BFO:0000066 GO:0005773 ! occurs in vacuole relationship: BFO:0000066 GO:0005773 ! occurs in vacuole [Term] id: GO:0007039 name: protein catabolic process in the vacuole namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of a protein in the vacuole, usually by the action of vacuolar proteases." [GOC:mah, GOC:vw] synonym: "vacuolar protein breakdown" RELATED [] synonym: "vacuolar protein catabolic process" RELATED [] synonym: "vacuolar protein catabolism" RELATED [] synonym: "vacuolar protein degradation" RELATED [] is_a: GO:0030163 ! protein catabolic process intersection_of: GO:0030163 ! protein catabolic process intersection_of: BFO:0000066 GO:0005773 ! occurs in vacuole relationship: BFO:0000066 GO:0005773 ! occurs in vacuole [Term] id: GO:0007040 name: lysosome organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a lysosome. A lysosome is a cytoplasmic, membrane-bounded organelle that is found in most animal cells and that contains a variety of hydrolases." [GOC:mah] subset: goslim_generic synonym: "lysosome organisation" EXACT [] synonym: "lysosome organization and biogenesis" RELATED [GOC:mah] is_a: GO:0080171 ! lytic vacuole organization intersection_of: GO:0016043 ! cellular component organization intersection_of: RO:0002592 GO:0005764 ! results in organization of lysosome relationship: RO:0002592 GO:0005764 ! results in organization of lysosome property_value: RO:0002161 NCBITaxon:4751 [Term] id: GO:0007041 name: lysosomal transport namespace: biological_process def: "The directed movement of substances into, out of or within a lysosome." [GOC:ai] is_a: GO:0007034 ! vacuolar transport intersection_of: GO:0006810 ! transport intersection_of: RO:0002344 GO:0005764 ! results in transport to from or in lysosome relationship: RO:0002344 GO:0005764 ! results in transport to from or in lysosome property_value: RO:0002161 NCBITaxon:4751 [Term] id: GO:0007043 name: cell-cell junction assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form a junction between cells." [GOC:ai] synonym: "intercellular junction assembly" EXACT [] is_a: GO:0034329 ! cell junction assembly is_a: GO:0045216 ! cell-cell junction organization intersection_of: GO:0034329 ! cell junction assembly intersection_of: RO:0002588 GO:0005911 ! results in assembly of cell-cell junction relationship: RO:0002588 GO:0005911 ! results in assembly of cell-cell junction property_value: RO:0002161 NCBITaxon:4751 [Term] id: GO:0007044 name: cell-substrate junction assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form a junction between a cell and its substrate." [GOC:mah] comment: The primary label for merged term was 'cell-substrate adherens junction assembly' GO:0007045. The term was merged into the parent 'cell-substrate junction assembly', because, based on the most recent litarature, 'adherens junction' is always a 'cell-cell junction' (PMID:20571587, PMID:17854762, PMID:21422226, PMID:28096264, PMID:28401269, PMID:26923917). synonym: "cell-substrate adherens junction assembly" RELATED [] is_a: GO:0034329 ! cell junction assembly is_a: GO:0150115 ! cell-substrate junction organization intersection_of: GO:0034329 ! cell junction assembly intersection_of: RO:0002588 GO:0030055 ! results in assembly of cell-substrate junction relationship: RO:0002588 GO:0030055 ! results in assembly of cell-substrate junction property_value: RO:0002161 NCBITaxon:4751 [Term] id: GO:0007049 name: cell cycle namespace: biological_process def: "The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division." [GOC:go_curators, GOC:mtg_cell_cycle] subset: gocheck_do_not_annotate subset: goslim_agr subset: goslim_candida subset: goslim_chembl subset: goslim_flybase_ribbon subset: goslim_pir subset: goslim_plant subset: goslim_plant_ribbon synonym: "cell-division cycle" EXACT [] xref: Reactome:R-HSA-1640170 "Cell Cycle" xref: Wikipedia:Cell_cycle is_a: GO:0009987 ! cellular process [Term] id: GO:0007059 name: chromosome segregation namespace: biological_process def: "The process in which genetic material, in the form of chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets. In eukaryotes, chromosome segregation begins with the condensation of chromosomes, includes chromosome separation, and ends when chromosomes have completed movement to the spindle poles." [GOC:jl, GOC:mah, GOC:mtg_cell_cycle, GOC:vw] subset: goslim_chembl subset: goslim_drosophila subset: goslim_generic subset: goslim_pir subset: goslim_prokaryote subset: goslim_yeast synonym: "chromosome division" EXACT [] synonym: "chromosome transmission" RELATED [] xref: Wikipedia:Chromosome_segregation is_a: GO:0022402 ! cell cycle process [Term] id: GO:0007076 name: mitotic chromosome condensation namespace: biological_process def: "The cell cycle process in which chromatin structure is compacted prior to and during mitosis in eukaryotic cells." [GOC:mah, ISBN:0815316194] xref: Reactome:R-HSA-2299718 "Condensation of Prophase Chromosomes" xref: Reactome:R-HSA-2514853 "Condensation of Prometaphase Chromosomes" is_a: GO:0030261 ! chromosome condensation is_a: GO:1903047 ! mitotic cell cycle process intersection_of: GO:0030261 ! chromosome condensation intersection_of: BFO:0000050 GO:0000278 ! part of mitotic cell cycle relationship: BFO:0000050 GO:0000070 ! part of mitotic sister chromatid segregation [Term] id: GO:0007077 name: mitotic nuclear membrane disassembly namespace: biological_process def: "The mitotic cell cycle process in which the controlled partial or complete breakdown of the nuclear membranes during occurs during mitosis." [GOC:bf, PMID:32848252] synonym: "local NEB" BROAD [] synonym: "mitotic nuclear envelope breakdown" EXACT [] synonym: "mitotic nuclear envelope catabolism" RELATED [] synonym: "mitotic nuclear envelope degradation" RELATED [] synonym: "mitotic nuclear envelope disassembly" RELATED [] synonym: "NEB" BROAD [] synonym: "nuclear envelope breakdown" BROAD [] xref: Reactome:R-HSA-2980766 "Nuclear Envelope Breakdown" is_a: GO:0051081 ! nuclear membrane disassembly is_a: GO:1903047 ! mitotic cell cycle process intersection_of: GO:0051081 ! nuclear membrane disassembly intersection_of: BFO:0000050 GO:0000278 ! part of mitotic cell cycle [Term] id: GO:0007088 name: regulation of mitotic nuclear division namespace: biological_process def: "Any process that modulates the frequency, rate or extent of mitosis." [GOC:go_curators] synonym: "regulation of mitosis" EXACT [] is_a: GO:0007346 ! regulation of mitotic cell cycle is_a: GO:0010564 ! regulation of cell cycle process is_a: GO:0051783 ! regulation of nuclear division intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0140014 ! regulates mitotic nuclear division relationship: RO:0002211 GO:0140014 ! regulates mitotic nuclear division [Term] id: GO:0007097 name: nuclear migration namespace: biological_process def: "The directed movement of the nucleus to a specific location within a cell." [GOC:ai] synonym: "establishment of cell nucleus localization" RELATED [] synonym: "establishment of localization of nucleus" RELATED [] synonym: "establishment of nucleus localisation" RELATED [GOC:mah] synonym: "establishment of nucleus localization" RELATED [] synonym: "establishment of position of nucleus" EXACT [] synonym: "nuclear movement" EXACT [] synonym: "nuclear positioning" EXACT [] synonym: "nucleus migration" EXACT [] synonym: "nucleus positioning" EXACT [] synonym: "positioning of nucleus" EXACT [] is_a: GO:0046907 ! intracellular transport is_a: GO:0051647 ! nucleus localization is_a: GO:0051656 ! establishment of organelle localization intersection_of: GO:0046907 ! intracellular transport intersection_of: RO:0004009 GO:0005634 ! has primary input nucleus [Term] id: GO:0007113 name: endomitotic cell cycle namespace: biological_process def: "A mitotic cell cycle in which chromosomes are replicated and sister chromatids separate, but spindle formation, nuclear membrane breakdown and nuclear division do not occur, resulting in an increased number of chromosomes in the cell." [GOC:curators, GOC:dos, GOC:expert_vm] comment: Note that this term should not be confused with 'abortive mitotic cell cycle ; GO:0033277'. Although abortive mitosis is sometimes called endomitosis, GO:0033277 refers to a process in which a mitotic spindle forms and chromosome separation begins. synonym: "endomitosis" RELATED [] xref: Wikipedia:Mitosis#Endomitosis is_a: GO:0000278 ! mitotic cell cycle [Term] id: GO:0007135 name: meiosis II namespace: biological_process def: "The second nuclear division of meiosis, in which the two chromatids in each chromosome are separated, resulting in four daughter nuclei from the two nuclei produced in meiosis II." [GOC:dph, GOC:mah, ISBN:0198547684] synonym: "meiosis II nuclear division" EXACT [] xref: Wikipedia:Meiosis#Meiosis_II is_a: GO:0061983 ! meiosis II cell cycle process is_a: GO:0140013 ! meiotic nuclear division [Term] id: GO:0007140 name: male meiotic nuclear division namespace: biological_process def: "A cell cycle process by which the cell nucleus divides as part of a meiotic cell cycle in the male germline." [GOC:dph, GOC:mah, GOC:vw] synonym: "male meiosis" RELATED [] synonym: "male nuclear division" BROAD [] is_a: GO:0140013 ! meiotic nuclear division intersection_of: GO:0000280 ! nuclear division intersection_of: BFO:0000050 GO:0048232 ! part of male gamete generation intersection_of: BFO:0000050 GO:0051321 ! part of meiotic cell cycle relationship: BFO:0000050 GO:0048232 ! part of male gamete generation property_value: RO:0002161 NCBITaxon:4751 [Term] id: GO:0007142 name: male meiosis II namespace: biological_process def: "A cell cycle process comprising the steps by which a cell progresses through male meiosis II, the second meiotic division in the male germline." [GOC:dph, GOC:mah] synonym: "male meiosis II nuclear division" EXACT [] is_a: GO:0007135 ! meiosis II is_a: GO:0007140 ! male meiotic nuclear division intersection_of: GO:0007135 ! meiosis II intersection_of: BFO:0000050 GO:0048232 ! part of male gamete generation intersection_of: BFO:0000050 GO:0051321 ! part of meiotic cell cycle property_value: RO:0002161 NCBITaxon:4751 [Term] id: GO:0007143 name: female meiotic nuclear division namespace: biological_process def: "A cell cycle process by which the cell nucleus divides as part of a meiotic cell cycle in the female germline." [GOC:dph, GOC:ems, GOC:mah, GOC:vw] comment: Note that female germ lines can be found in female or hermaphroditic organisms, so this term can be used to annotate gene products from hermaphrodites such as those of C. elegans. See also the biological process term 'meiotic nuclear division; GO:0140013'. synonym: "female meiosis" BROAD [] synonym: "female meiotic division" BROAD [] is_a: GO:0140013 ! meiotic nuclear division intersection_of: GO:0000280 ! nuclear division intersection_of: BFO:0000050 GO:0007292 ! part of female gamete generation intersection_of: BFO:0000050 GO:0051321 ! part of meiotic cell cycle relationship: BFO:0000050 GO:0007292 ! part of female gamete generation property_value: RO:0002161 NCBITaxon:4751 [Term] id: GO:0007147 name: female meiosis II namespace: biological_process def: "The cell cycle process in which the second meiotic division occurs in the female germline." [GOC:mah] synonym: "female meiosis II nuclear division" EXACT [] is_a: GO:0007135 ! meiosis II is_a: GO:0007143 ! female meiotic nuclear division intersection_of: GO:0007135 ! meiosis II intersection_of: BFO:0000050 GO:0007292 ! part of female gamete generation intersection_of: BFO:0000050 GO:0051321 ! part of meiotic cell cycle property_value: RO:0002161 NCBITaxon:4751 [Term] id: GO:0007154 name: cell communication namespace: biological_process def: "Any process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment." [GOC:mah] subset: goslim_pir subset: goslim_plant xref: Wikipedia:Cell_signaling is_a: GO:0009987 ! cellular process [Term] id: GO:0007155 name: cell adhesion namespace: biological_process def: "The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf] subset: goslim_candida subset: goslim_chembl subset: goslim_drosophila subset: goslim_euk_cellular_processes_ribbon subset: goslim_generic subset: goslim_metagenomics subset: goslim_pir subset: goslim_pombe subset: goslim_prokaryote synonym: "cell adhesion molecule activity" RELATED [] synonym: "single organism cell adhesion" RELATED [] xref: Wikipedia:Cell_adhesion is_a: GO:0009987 ! cellular process creation_date: 2014-04-15T15:59:10Z [Term] id: GO:0007159 name: leukocyte cell-cell adhesion namespace: biological_process def: "The attachment of a leukocyte to another cell via adhesion molecules." [GOC:go_curators] synonym: "leukocyte adhesion" EXACT [] synonym: "leukocyte cell adhesion" EXACT [] is_a: BFO:0000003 is_a: GO:0098609 ! cell-cell adhesion intersection_of: GO:0098609 ! cell-cell adhesion intersection_of: has_participant CL:0000738 ! leukocyte relationship: has_participant CL:0000738 ! leukocyte relationship: RO:0002162 NCBITaxon:7742 ! in taxon Vertebrata [Term] id: GO:0007162 name: negative regulation of cell adhesion namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cell adhesion." [GOC:go_curators] synonym: "cell adhesion receptor inhibitor activity" RELATED [] synonym: "down regulation of cell adhesion" EXACT [] synonym: "down-regulation of cell adhesion" EXACT [] synonym: "downregulation of cell adhesion" EXACT [] synonym: "inhibition of cell adhesion" NARROW [] is_a: GO:0030155 ! regulation of cell adhesion is_a: GO:0048523 ! negative regulation of cellular process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0007155 ! negatively regulates cell adhesion relationship: RO:0002212 GO:0007155 ! negatively regulates cell adhesion [Term] id: GO:0007163 name: establishment or maintenance of cell polarity namespace: biological_process def: "Any cellular process that results in the specification, formation or maintenance of anisotropic intracellular organization or cell growth patterns." [GOC:mah] subset: goslim_drosophila subset: goslim_generic subset: goslim_pombe subset: goslim_prokaryote synonym: "cell polarity" RELATED [GOC:mah, GOC:vw] synonym: "establishment and/or maintenance of cell polarity" RELATED [] synonym: "establishment and/or maintenance of cell polarization" RELATED [] is_a: GO:0009987 ! cellular process [Term] id: GO:0007165 name: signal transduction namespace: biological_process def: "The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11] comment: Note that signal transduction is defined broadly to include a ligand interacting with a receptor, downstream signaling steps and a response being triggered. A change in form of the signal in every step is not necessary. Note that in many cases the end of this process is regulation of the initiation of transcription. Note that specific transcription factors may be annotated to this term, but core/general transcription machinery such as RNA polymerase should not. subset: goslim_candida subset: goslim_chembl subset: goslim_metagenomics subset: goslim_plant subset: goslim_plant_ribbon synonym: "signaling cascade" NARROW [] synonym: "signaling pathway" RELATED [] synonym: "signalling cascade" NARROW [] synonym: "signalling pathway" RELATED [] xref: Reactome:R-HSA-212718 "EGFR interacts with phospholipase C-gamma" xref: Wikipedia:Signal_transduction is_a: GO:0009987 ! cellular process is_a: GO:0050794 ! regulation of cellular process relationship: BFO:0000050 GO:0007154 ! part of cell communication relationship: BFO:0000050 GO:0023052 ! part of signaling relationship: BFO:0000050 GO:0051716 ! part of cellular response to stimulus [Term] id: GO:0007166 name: cell surface receptor signaling pathway namespace: biological_process def: "The series of molecular signals initiated by an extracellular ligand binding to a receptor located on the cell surface. The pathway ends with regulation of a downstream cellular process, e.g. transcription." [GOC:signaling] subset: goslim_drosophila synonym: "cell surface receptor linked signal transduction" EXACT [] synonym: "cell surface receptor linked signaling pathway" EXACT [GOC:bf] synonym: "cell surface receptor linked signalling pathway" EXACT [GOC:mah] xref: Reactome:R-HSA-73887 "Death Receptor Signaling" is_a: GO:0007165 ! signal transduction [Term] id: GO:0007167 name: enzyme-linked receptor protein signaling pathway namespace: biological_process def: "The series of molecular signals initiated by an extracellular ligand binding to a receptor on the surface of the target cell, where the receptor possesses catalytic activity or is closely associated with an enzyme such as a protein kinase, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:mah, GOC:signaling, ISBN:0815316194] synonym: "enzyme linked receptor protein signaling pathway" EXACT [] synonym: "enzyme linked receptor protein signalling pathway" EXACT [] is_a: GO:0007166 ! cell surface receptor signaling pathway [Term] id: GO:0007169 name: cell surface receptor protein tyrosine kinase signaling pathway namespace: biological_process def: "The series of molecular signals initiated by an extracellular ligand binding to a receptor on the surface of the target cell where the receptor possesses tyrosine kinase activity, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:ceb, GOC:signaling] synonym: "transmembrane receptor protein serine/threonine kinase signaling pathway" BROAD [] synonym: "transmembrane receptor protein tyrosine kinase signalling pathway" EXACT [] xref: Reactome:R-HSA-187015 "Activation of TRKA receptors" is_a: GO:0007167 ! enzyme-linked receptor protein signaling pathway property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/26955" xsd:anyURI [Term] id: GO:0007186 name: G protein-coupled receptor signaling pathway namespace: biological_process def: "The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor] subset: goslim_drosophila synonym: "dimeric G-protein coupled receptor signaling pathway" NARROW [] synonym: "dimeric G-protein coupled receptor signalling pathway" NARROW [GOC:mah] synonym: "G protein coupled receptor protein signaling pathway" EXACT [] synonym: "G protein coupled receptor protein signalling pathway" EXACT [] synonym: "G-protein coupled receptor protein signal transduction" EXACT [] synonym: "G-protein coupled receptor protein signaling pathway" EXACT [GOC:bf] synonym: "G-protein coupled receptor signaling pathway via GPCR dimer" NARROW [GOC:bf] synonym: "G-protein coupled receptor signalling pathway" EXACT [] synonym: "G-protein-coupled receptor protein signalling pathway" EXACT [] synonym: "GPCR signaling pathway" EXACT [] synonym: "GPCR signalling pathway" EXACT [] xref: Reactome:R-HSA-373076 "Class A/1 (Rhodopsin-like receptors)" xref: Reactome:R-HSA-388396 "GPCR downstream signalling" is_a: GO:0007165 ! signal transduction intersection_of: GO:0007165 ! signal transduction intersection_of: RO:0002224 GO:0004930 ! starts with G protein-coupled receptor activity relationship: RO:0002224 GO:0004930 ! starts with G protein-coupled receptor activity [Term] id: GO:0007204 name: positive regulation of cytosolic calcium ion concentration namespace: biological_process def: "Any process that increases the concentration of calcium ions in the cytosol." [GOC:ai] synonym: "cytoplasmic calcium ion concentration elevation" BROAD [] synonym: "cytosolic calcium ion concentration elevation" EXACT [] synonym: "elevation of calcium ion concentration in cytoplasm" BROAD [] synonym: "elevation of calcium ion concentration in cytosol" EXACT [] synonym: "elevation of cytoplasmic calcium ion concentration" BROAD [] synonym: "elevation of cytosolic calcium ion concentration" EXACT [] is_a: GO:0065008 ! regulation of biological quality [Term] id: GO:0007210 name: serotonin receptor signaling pathway namespace: biological_process def: "The series of molecular signals generated as a consequence of a serotonin receptor binding to one of its physiological ligands." [GOC:mah] synonym: "serotonin receptor signalling pathway" EXACT [] is_a: GO:0007165 ! signal transduction intersection_of: GO:0007165 ! signal transduction intersection_of: RO:0002224 GO:0099589 ! starts with serotonin receptor activity relationship: BFO:0000050 GO:1903351 ! part of cellular response to dopamine relationship: RO:0002224 GO:0099589 ! starts with serotonin receptor activity [Term] id: GO:0007213 name: G protein-coupled acetylcholine receptor signaling pathway namespace: biological_process def: "A G protein-coupled receptor signaling pathway initiated by a ligand binding to an acetylcholine receptor on the surface of a target cell, and ends with regulation of a downstream cellular process, e.g. transcription." [GOC:mah, ISBN:0815316194] synonym: "acetylcholine receptor signalling, muscarinic pathway" EXACT [] synonym: "G-protein coupled acetylcholine receptor signaling pathway" EXACT [] synonym: "muscarinic acetylcholine receptor signaling pathway" EXACT [GOC:bf] is_a: GO:0007186 ! G protein-coupled receptor signaling pathway is_a: GO:0095500 ! acetylcholine receptor signaling pathway intersection_of: GO:0007165 ! signal transduction intersection_of: RO:0002224 GO:0016907 ! starts with G protein-coupled acetylcholine receptor activity relationship: RO:0002224 GO:0016907 ! starts with G protein-coupled acetylcholine receptor activity [Term] id: GO:0007214 name: gamma-aminobutyric acid signaling pathway namespace: biological_process def: "The series of molecular signals generated by the binding of gamma-aminobutyric acid (GABA, 4-aminobutyrate), an amino acid which acts as a neurotransmitter in some organisms, to its receptor on the surface of a target cell." [GOC:mah] synonym: "4-aminobutanoate signaling pathway" EXACT [] synonym: "4-aminobutanoate signalling pathway" EXACT [] synonym: "4-aminobutyrate signaling pathway" EXACT [] synonym: "4-aminobutyrate signalling pathway" EXACT [] synonym: "GABA signaling pathway" EXACT [] synonym: "GABA signalling pathway" EXACT [] synonym: "gamma-aminobutyric acid signalling pathway" EXACT [] is_a: GO:0007267 ! cell-cell signaling intersection_of: GO:0007267 ! cell-cell signaling intersection_of: RO:0002224 GO:0016917 ! starts with GABA receptor activity relationship: RO:0002224 GO:0016917 ! starts with GABA receptor activity [Term] id: GO:0007215 name: glutamate receptor signaling pathway namespace: biological_process def: "The series of molecular signals initiated by the binding of glutamate to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:mah, GOC:signaling, PMID:9131252] synonym: "glutamate signaling pathway" EXACT [GOC:bf] synonym: "glutamate signalling pathway" EXACT [] is_a: GO:0007166 ! cell surface receptor signaling pathway intersection_of: GO:0007165 ! signal transduction intersection_of: RO:0002224 GO:0008066 ! starts with glutamate receptor activity relationship: RO:0002224 GO:0008066 ! starts with glutamate receptor activity [Term] id: GO:0007216 name: G protein-coupled glutamate receptor signaling pathway namespace: biological_process def: "A G protein-coupled receptor signaling pathway initiated by glutamate binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process." [GOC:mah, GOC:signaling, PMID:9131252] synonym: "G-protein coupled glutamate receptor signaling pathway" EXACT [] synonym: "metabotropic glutamate receptor signaling pathway" EXACT [GOC:bf] synonym: "metabotropic glutamate receptor signalling pathway" EXACT [] is_a: GO:0007186 ! G protein-coupled receptor signaling pathway is_a: GO:0007215 ! glutamate receptor signaling pathway intersection_of: GO:0007165 ! signal transduction intersection_of: RO:0002224 GO:0098988 ! starts with G protein-coupled glutamate receptor activity relationship: RO:0002224 GO:0098988 ! starts with G protein-coupled glutamate receptor activity [Term] id: GO:0007218 name: neuropeptide signaling pathway namespace: biological_process def: "A G protein-coupled receptor signaling pathway initiated by a neuropeptide binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process." [GOC:mah, ISBN:0815316194] synonym: "neuropeptide signalling pathway" EXACT [] is_a: GO:0007186 ! G protein-coupled receptor signaling pathway property_value: RO:0002161 NCBITaxon:4751 [Term] id: GO:0007267 name: cell-cell signaling namespace: biological_process def: "Any process that mediates the transfer of information from one cell to another. This process includes signal transduction in the receiving cell and, where applicable, release of a ligand and any processes that actively facilitate its transport and presentation to the receiving cell. Examples include signaling via soluble ligands, via cell adhesion molecules and via gap junctions." [GOC:dos, GOC:mah] subset: goslim_chembl subset: goslim_plant synonym: "cell-cell signalling" EXACT [] is_a: GO:0007154 ! cell communication is_a: GO:0023052 ! signaling [Term] id: GO:0007268 name: chemical synaptic transmission namespace: biological_process def: "The vesicular release of classical neurotransmitter molecules from a presynapse, across a chemical synapse, the subsequent activation of neurotransmitter receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse." [GOC:jl, MeSH:D009435] subset: goslim_synapse synonym: "neurotransmission" RELATED [GOC:dph] synonym: "signal transmission across a synapse" BROAD [] synonym: "synaptic transmission" BROAD [] xref: Reactome:R-HSA-112316 "Neuronal System" xref: Reactome:R-HSA-442720 "CREB1 phosphorylation through the activation of Adenylate Cyclase" xref: Reactome:R-HSA-442729 "CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde" xref: Reactome:R-HSA-442742 "CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling" xref: Reactome:R-HSA-451307 "Activation of Na-permeable kainate receptors" xref: Reactome:R-HSA-451308 "Activation of Ca-permeable Kainate Receptor" xref: Reactome:R-HSA-9619229 "Activation of RAC1 downstream of NMDARs" xref: Reactome:R-HSA-9619483 "Activation of AMPK downstream of NMDARs" xref: Reactome:R-HSA-9620244 "Long-term potentiation" xref: Wikipedia:Neurotransmission is_a: GO:0098916 ! anterograde trans-synaptic signaling relationship: has_participant GO:0045202 ! synapse [Term] id: GO:0007269 name: neurotransmitter secretion namespace: biological_process def: "The regulated release of neurotransmitter from the presynapse into the synaptic cleft via calcium-regulated exocytosis during synaptic transmission." [GOC:dph] comment: A neurotransmitter is any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell. Among the many substances that have the properties of a neurotransmitter are acetylcholine, noradrenaline, adrenaline, dopamine, glycine, gamma-aminobutyrate, glutamic acid, substance P, enkephalins, endorphins and serotonin. subset: goslim_synapse synonym: "neurotransmitter release" EXACT [] synonym: "neurotransmitter secretory pathway" EXACT [] xref: Reactome:R-HSA-112310 "Neurotransmitter release cycle" is_a: GO:0006836 ! neurotransmitter transport is_a: GO:0051649 ! establishment of localization in cell is_a: GO:0099643 ! signal release from synapse relationship: BFO:0000050 GO:0007268 ! part of chemical synaptic transmission relationship: BFO:0000066 GO:0098793 ! occurs in presynapse relationship: RO:0002338 GO:0098793 ! has target start location presynapse relationship: RO:0002339 GO:0043083 ! has target end location synaptic cleft [Term] id: GO:0007271 name: synaptic transmission, cholinergic namespace: biological_process def: "The vesicular release of acetylcholine from a presynapse, across a chemical synapse, the subsequent activation of dopamine receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse." [GOC:dos, Wikipedia:Cholinergic] synonym: "cholinergic synaptic transmission" EXACT [] is_a: GO:0007268 ! chemical synaptic transmission relationship: has_participant CHEBI:15355 [Term] id: GO:0007272 name: ensheathment of neurons namespace: biological_process def: "The process in which glial cells envelop neuronal cell bodies and/or axons to form an insulating layer. This can take the form of myelinating or non-myelinating ensheathment." [GOC:dgh, GOC:dph, GOC:tb] synonym: "ionic insulation of neurons by glial cells" RELATED [] is_a: BFO:0000003 is_a: GO:0009987 ! cellular process relationship: BFO:0000050 GO:0007399 ! part of nervous system development relationship: has_participant CL:0000125 ! glial cell relationship: has_participant CL:0000540 ! neuron [Term] id: GO:0007274 name: neuromuscular synaptic transmission namespace: biological_process def: "The process of synaptic transmission from a neuron to a muscle, across a synapse." [GOC:dos, GOC:jl, MeSH:D009435] is_a: GO:0007268 ! chemical synaptic transmission [Term] id: GO:0007275 name: multicellular organism development namespace: biological_process def: "The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb] comment: Note that this term was 'developmental process'. subset: gocheck_do_not_annotate subset: goslim_chembl subset: goslim_plant is_a: GO:0032501 ! multicellular organismal process is_a: GO:0048856 ! anatomical structure development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002295 UBERON:0000468 ! results in developmental progression of multicellular organism relationship: RO:0002295 UBERON:0000468 ! results in developmental progression of multicellular organism property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/21234" xsd:anyURI property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0007276 name: gamete generation namespace: biological_process def: "The generation and maintenance of gametes in a multicellular organism. A gamete is a haploid reproductive cell." [GOC:ems, GOC:mtg_sensu] synonym: "gametogenesis" RELATED [] is_a: GO:0048609 ! multicellular organismal reproductive process relationship: BFO:0000050 GO:0019953 ! part of sexual reproduction property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4751 [Term] id: GO:0007277 name: pole cell development namespace: biological_process def: "The process whose specific outcome is the progression of the pole cell over time, from its formation to the mature structure." [GOC:jid] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0048468 ! cell development intersection_of: GO:0032502 ! developmental process intersection_of: RO:0002296 CL:0000301 ! results in development of pole cell relationship: BFO:0000050 GO:0007276 ! part of gamete generation relationship: RO:0002296 CL:0000301 ! results in development of pole cell property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4751 [Term] id: GO:0007279 name: pole cell formation namespace: biological_process def: "Formation of a small group of cells (pole cells) at the posterior pole of the insect blastula. They are the first cells to cellularize after the arrival of nuclei at the end of the syncytial blastula stage and are the precursors to the insect germ cells." [GOC:bf, PMID:9988212] comment: See also the Cell Ontology term 'pole cell ; CL:0000301'. is_a: BFO:0000003 is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0007349 ! cellularization intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 CL:0000301 ! results in formation of anatomical entity pole cell relationship: BFO:0000050 GO:0007277 ! part of pole cell development relationship: RO:0002297 CL:0000301 ! results in formation of anatomical entity pole cell property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4751 [Term] id: GO:0007281 name: germ cell development namespace: biological_process def: "The process whose specific outcome is the progression of an immature germ cell over time, from its formation to the mature structure (gamete). A germ cell is any reproductive cell in a multicellular organism." [GOC:go_curators] synonym: "gametogenesis" NARROW [] synonym: "germ-cell development" EXACT [] synonym: "primordial germ cell development" NARROW [] xref: Reactome:R-HSA-9827857 "Specification of primordial germ cells" is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism is_a: GO:0048468 ! cell development intersection_of: GO:0032502 ! developmental process intersection_of: RO:0002296 CL:0000586 ! results in development of germ cell relationship: BFO:0000050 GO:0007276 ! part of gamete generation relationship: RO:0002296 CL:0000586 ! results in development of germ cell property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4751 [Term] id: GO:0007282 name: cystoblast division namespace: biological_process def: "Any of the rounds of incomplete mitosis undergone by a cystoblast to form a cyst of interconnected cells." [PMID:21452446] synonym: "cystoblast cell division" EXACT [] is_a: BFO:0000003 is_a: GO:0008356 ! asymmetric cell division intersection_of: GO:0008356 ! asymmetric cell division intersection_of: RO:0004009 CL:0000722 ! has primary input cystoblast relationship: BFO:0000050 GO:0007281 ! part of germ cell development relationship: RO:0002162 NCBITaxon:6656 ! in taxon Arthropoda relationship: RO:0004009 CL:0000722 ! has primary input cystoblast [Term] id: GO:0007283 name: spermatogenesis namespace: biological_process def: "The developmental process by which male germ line stem cells self renew or give rise to successive cell types resulting in the development of a spermatozoa." [GOC:jid, ISBN:9780878933846, PMID:28073824, PMID:30990821] synonym: "generation of spermatozoa" EXACT systematic_synonym [] xref: Wikipedia:Spermatogenesis is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0048232 ! male gamete generation property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4751 [Term] id: GO:0007284 name: spermatogonial cell division namespace: biological_process def: "The mitotic divisions of the primary spermatogonial cell (a primordial male germ cell) to form secondary spermatogonia (primary spermatocytes)." [GOC:bf, GOC:pr, ISBN:0879694238] comment: See also the Cell Ontology terms 'spermatogonium ; CL:0000020' and 'primary spermatocyte ; CL:0000656'. synonym: "spermatogonium division" EXACT [] is_a: BFO:0000003 is_a: GO:0051301 ! cell division intersection_of: GO:0051301 ! cell division intersection_of: RO:0004009 CL:0000020 ! has primary input spermatogonium relationship: BFO:0000050 GO:0007283 ! part of spermatogenesis relationship: RO:0004009 CL:0000020 ! has primary input spermatogonium property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4751 [Term] id: GO:0007285 name: primary spermatocyte growth namespace: biological_process def: "The phase of growth and gene expression that male germ cells undergo as they enter the spermatocyte stage. The cells grow in volume and transcribe most of the gene products needed for the morphological events that follow meiosis." [GOC:jid, ISBN:0879694238] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0048588 ! developmental cell growth intersection_of: GO:0040007 ! growth intersection_of: RO:0002343 CL:0000656 ! results in growth of primary spermatocyte relationship: BFO:0000050 GO:0007283 ! part of spermatogenesis relationship: RO:0002343 CL:0000656 ! results in growth of primary spermatocyte property_value: RO:0002161 NCBITaxon:4751 [Term] id: GO:0007286 name: spermatid development namespace: biological_process def: "The process whose specific outcome is the progression of a spermatid over time, from its formation to the mature structure." [GOC:dph, GOC:go_curators] synonym: "spermatid cell development" EXACT [] synonym: "spermiogenesis" EXACT [] xref: Wikipedia:Spermiogenesis is_a: GO:0007281 ! germ cell development intersection_of: GO:0032502 ! developmental process intersection_of: RO:0002296 CL:0000018 ! results in development of spermatid relationship: BFO:0000050 GO:0048515 ! part of spermatid differentiation relationship: RO:0002296 CL:0000018 ! results in development of spermatid property_value: RO:0002161 NCBITaxon:3176 property_value: RO:0002161 NCBITaxon:3378 property_value: RO:0002161 NCBITaxon:3398 property_value: RO:0002161 NCBITaxon:4751 property_value: RO:0002161 NCBITaxon:5782 [Term] id: GO:0007288 name: sperm axoneme assembly namespace: biological_process def: "The assembly and organization of the sperm flagellar axoneme, the bundle of microtubules and associated proteins that forms the core of the eukaryotic sperm flagellum, and is responsible for movement." [GOC:bf, GOC:cilia, ISBN:0198547684] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0035082 ! axoneme assembly intersection_of: GO:0035082 ! axoneme assembly intersection_of: BFO:0000066 CL:0000019 ! occurs in sperm relationship: BFO:0000050 GO:0120316 ! part of sperm flagellum assembly property_value: RO:0002161 NCBITaxon:3176 property_value: RO:0002161 NCBITaxon:3378 property_value: RO:0002161 NCBITaxon:3398 property_value: RO:0002161 NCBITaxon:4751 property_value: RO:0002161 NCBITaxon:5782 [Term] id: GO:0007289 name: spermatid nucleus differentiation namespace: biological_process def: "The specialization of the spermatid nucleus during the development of a spermatid into a mature male gamete competent for fertilization." [GOC:bf, GOC:dph, GOC:jl, GOC:mah] comment: See also the Cell Ontology term 'spermatid ; CL:0000018'. synonym: "spermatid nuclear differentiation" EXACT [] is_a: GO:0006997 ! nucleus organization relationship: BFO:0000050 GO:0007286 ! part of spermatid development property_value: RO:0002161 NCBITaxon:3176 property_value: RO:0002161 NCBITaxon:3378 property_value: RO:0002161 NCBITaxon:3398 property_value: RO:0002161 NCBITaxon:4751 property_value: RO:0002161 NCBITaxon:5782 [Term] id: GO:0007292 name: female gamete generation namespace: biological_process def: "Generation of the female gamete; specialised haploid cells produced by meiosis and along with a male gamete takes part in sexual reproduction." [GOC:dph, ISBN:0198506732] is_a: GO:0007276 ! gamete generation property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4751 [Term] id: GO:0007293 name: germarium-derived egg chamber formation namespace: biological_process def: "Construction of a stage-1 egg chamber in the anterior part of the germarium, from the progeny of germ-line and somatic stem cells. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, ISBN:0879694238] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis relationship: BFO:0000050 GO:0048477 ! part of oogenesis relationship: RO:0002162 NCBITaxon:6656 ! in taxon Arthropoda [Term] id: GO:0007297 name: follicle cell of egg chamber migration namespace: biological_process def: "The directed movement of an ovarian follicle cell that takes place during oogenesis. During egg chamber formation, follicle cells migrate to envelop the germ-line cysts and move in between cysts. At stage 10B, follicle cells migrate centripetally between the nurse cells and the oocyte, enclosing the anterior of the egg. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:10822261] synonym: "follicle cell migration" BROAD [] is_a: GO:0010631 ! epithelial cell migration intersection_of: GO:0016477 ! cell migration intersection_of: RO:0002565 CL:0000477 ! results in movement of follicle cell of egg chamber relationship: BFO:0000050 GO:0030707 ! part of follicle cell of egg chamber development relationship: RO:0002565 CL:0000477 ! results in movement of follicle cell of egg chamber [Term] id: GO:0007298 name: border follicle cell migration namespace: biological_process def: "The directed movement of a border cell through the nurse cells to reach the oocyte. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:10822261] synonym: "border cell migration" BROAD [] is_a: GO:0007297 ! follicle cell of egg chamber migration intersection_of: GO:0016477 ! cell migration intersection_of: RO:0002565 CL:0000579 ! results in movement of border follicle cell relationship: RO:0002565 CL:0000579 ! results in movement of border follicle cell [Term] id: GO:0007308 name: oocyte construction namespace: biological_process def: "The synthesis, deposition, and organization of the materials in a cell of an ovary; where the cell can then undergo meiosis and form an ovum. An example of this is found in Drosophila melanogaster." [GOC:dph, GOC:ems, GOC:mtg_sensu, GOC:tb, ISBN:0198506732] synonym: "oocyte arrangement" EXACT [GOC:dph, GOC:tb] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0048469 ! cell maturation intersection_of: GO:0032502 ! developmental process intersection_of: RO:0002297 CL:0000023 ! results in formation of anatomical entity oocyte relationship: BFO:0000050 GO:0048599 ! part of oocyte development relationship: RO:0002297 CL:0000023 ! results in formation of anatomical entity oocyte [Term] id: GO:0007309 name: oocyte axis specification namespace: biological_process def: "The establishment, maintenance and elaboration of an axis in the oocyte. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, ISBN:0879694238] synonym: "oocyte axis determination" RELATED [] is_a: BFO:0000003 is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0009798 ! axis specification intersection_of: GO:0009798 ! axis specification intersection_of: BFO:0000066 CL:0000023 ! occurs in oocyte relationship: BFO:0000050 GO:0007308 ! part of oocyte construction relationship: BFO:0000066 CL:0000023 ! occurs in oocyte [Term] id: GO:0007314 name: oocyte anterior/posterior axis specification namespace: biological_process def: "Polarization of the oocyte along its anterior-posterior axis. An example of this is found in Drosophila melanogaster." [GOC:dph, GOC:mtg_sensu, GOC:tb, ISBN:0879694238] synonym: "oocyte anterior/posterior axis determination" EXACT [GOC:dph, GOC:tb] is_a: GO:0007309 ! oocyte axis specification is_a: GO:0009948 ! anterior/posterior axis specification intersection_of: GO:0009948 ! anterior/posterior axis specification intersection_of: BFO:0000066 CL:0000023 ! occurs in oocyte relationship: BFO:0000050 GO:0008358 ! part of maternal determination of anterior/posterior axis, embryo [Term] id: GO:0007320 name: insemination namespace: biological_process def: "The introduction of semen or sperm into the genital tract of a female." [ISBN:0582227089] xref: Wikipedia:Insemination is_a: GO:0044703 ! multi-organism reproductive process is_a: GO:0044706 ! multi-multicellular organism process is_a: GO:0048609 ! multicellular organismal reproductive process relationship: BFO:0000050 GO:0007620 ! part of copulation [Term] id: GO:0007338 name: single fertilization namespace: biological_process def: "The union of male and female gametes to form a zygote." [GOC:ems, GOC:mtg_sensu] synonym: "zygote biosynthesis" RELATED [] synonym: "zygote formation" RELATED [] xref: Reactome:R-HSA-1187000 "Fertilization" is_a: GO:0009566 ! fertilization relationship: RO:0002162 NCBITaxon:2759 ! in taxon Eukaryota property_value: RO:0002161 NCBITaxon:58024 [Term] id: GO:0007343 name: egg activation namespace: biological_process def: "The process in which the egg becomes metabolically active, initiates protein and DNA synthesis and undergoes structural changes to its cortex and/or cytoplasm." [GOC:bf, PMID:9630751] xref: Wikipedia:Egg_activation is_a: BFO:0000003 is_a: GO:0001775 ! cell activation intersection_of: GO:0001775 ! cell activation intersection_of: RO:0004009 CL:0000025 ! has primary input egg cell relationship: BFO:0000050 GO:0007338 ! part of single fertilization relationship: RO:0004009 CL:0000025 ! has primary input egg cell [Term] id: GO:0007346 name: regulation of mitotic cell cycle namespace: biological_process def: "Any process that modulates the rate or extent of progress through the mitotic cell cycle." [GOC:dph, GOC:go_curators, GOC:tb] synonym: "mitotic cell cycle modulation" EXACT [] synonym: "mitotic cell cycle regulation" EXACT [] synonym: "mitotic cell cycle regulator" RELATED [] synonym: "modulation of mitotic cell cycle progression" EXACT [] synonym: "regulation of mitotic cell cycle progression" EXACT [] synonym: "regulation of progression through mitotic cell cycle" EXACT [GOC:dph, GOC:tb] xref: Reactome:R-HSA-2465910 "MASTL Facilitates Mitotic Progression" xref: Reactome:R-HSA-68911 "G2 Phase" is_a: GO:0051726 ! regulation of cell cycle intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0000278 ! regulates mitotic cell cycle relationship: RO:0002211 GO:0000278 ! regulates mitotic cell cycle [Term] id: GO:0007349 name: cellularization namespace: biological_process def: "The separation of a multi-nucleate cell or syncytium into individual cells. An example of this is found in Drosophila melanogaster embryo development." [GOC:go_curators, GOC:mtg_sensu, ISBN:0716731363] is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis relationship: BFO:0000050 GO:0007275 ! part of multicellular organism development property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0007350 name: blastoderm segmentation namespace: biological_process def: "The hierarchical steps resulting in the progressive subdivision of the anterior/posterior axis of the embryo." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238] is_a: GO:0009880 ! embryonic pattern specification is_a: GO:0035282 ! segmentation property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0007351 name: tripartite regional subdivision namespace: biological_process def: "Subdivision of the embryo along the anterior/posterior axis into anterior, posterior and terminal regions." [GOC:dph, GOC:isa_complete, http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238] is_a: GO:0003002 ! regionalization relationship: BFO:0000050 GO:0007350 ! part of blastoderm segmentation property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0007354 name: zygotic determination of anterior/posterior axis, embryo namespace: biological_process def: "The specification of the anterior/posterior axis of the embryo by products of genes expressed in the zygote; exemplified in insects by the gap genes, pair rule genes and segment polarity gene cascade." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238] is_a: BFO:0000003 is_a: GO:0008595 ! anterior/posterior axis specification, embryo intersection_of: GO:0008595 ! anterior/posterior axis specification, embryo intersection_of: BFO:0000066 CL:0000365 ! occurs in animal zygote relationship: BFO:0000066 CL:0000365 ! occurs in animal zygote property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0007369 name: gastrulation namespace: biological_process def: "A complex and coordinated series of cellular movements that occurs at the end of cleavage during embryonic development of most animals. The details of gastrulation vary from species to species, but usually result in the formation of the three primary germ layers, ectoderm, mesoderm and endoderm." [GOC:curators, ISBN:9780878933846] subset: goslim_drosophila xref: Reactome:R-HSA-9758941 "Gastrulation" xref: Wikipedia:Gastrulation is_a: BFO:0000003 is_a: GO:0048598 ! embryonic morphogenesis relationship: BFO:0000051 GO:0001705 ! has part ectoderm formation relationship: BFO:0000051 GO:0001706 ! has part endoderm formation relationship: BFO:0000051 GO:0001707 ! has part mesoderm formation [Term] id: GO:0007378 name: amnioserosa formation namespace: biological_process def: "Formation of the amnioserosa, an epithelium that occupies a hole in the embryonic dorsal epidermis. This occurs by the transformation of a narrow strip of cells at the dorsal midline of the blastoderm from columnar to squamous cells, accompanied by a lateral shift." [ISBN:0879694238] is_a: BFO:0000003 is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0010302 ! results in formation of anatomical entity amnioserosa relationship: BFO:0000050 GO:0010004 ! part of gastrulation involving germ band extension relationship: RO:0002297 UBERON:0010302 ! results in formation of anatomical entity amnioserosa [Term] id: GO:0007389 name: pattern specification process namespace: biological_process def: "Any developmental process that results in the creation of defined areas or spaces within an organism to which cells respond and eventually are instructed to differentiate." [GOC:go_curators, GOC:isa_complete, ISBN:0521436125] subset: goslim_drosophila synonym: "pattern biosynthesis" RELATED [] synonym: "pattern formation" RELATED [] is_a: GO:0032501 ! multicellular organismal process relationship: BFO:0000050 GO:0007275 ! part of multicellular organism development property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0007398 name: ectoderm development namespace: biological_process def: "The process whose specific outcome is the progression of the ectoderm over time, from its formation to the mature structure. In animal embryos, the ectoderm is the outer germ layer of the embryo, formed during gastrulation." [GOC:dph, GOC:tb] is_a: GO:0009888 ! tissue development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0000924 ! results in development of ectoderm relationship: RO:0002296 UBERON:0000924 ! results in development of ectoderm [Term] id: GO:0007399 name: nervous system development namespace: biological_process def: "The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state." [GOC:dgh] subset: goslim_drosophila synonym: "pan-neural process" RELATED [] xref: Reactome:R-HSA-9675108 "Nervous system development" is_a: GO:0048731 ! system development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0001016 ! results in development of nervous system relationship: RO:0002162 NCBITaxon:6072 ! in taxon Eumetazoa relationship: RO:0002296 UBERON:0001016 ! results in development of nervous system [Term] id: GO:0007405 name: neuroblast proliferation namespace: biological_process def: "The expansion of a neuroblast population by cell division. A neuroblast is any cell that will divide and give rise to a neuron." [GOC:ai, GOC:mtg_sensu, GOC:sart] is_a: BFO:0000003 is_a: GO:0061351 ! neural precursor cell proliferation intersection_of: GO:0008283 ! cell population proliferation intersection_of: RO:0012003 CL:0000031 ! acts on population of neuroblast (sensu Vertebrata) relationship: BFO:0000050 GO:0048699 ! part of generation of neurons relationship: RO:0012003 CL:0000031 ! acts on population of neuroblast (sensu Vertebrata) [Term] id: GO:0007406 name: negative regulation of neuroblast proliferation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the proliferation of neuroblasts." [GOC:ai] synonym: "down regulation of neuroblast proliferation" EXACT [] synonym: "down-regulation of neuroblast proliferation" EXACT [] synonym: "downregulation of neuroblast proliferation" EXACT [] synonym: "inhibition of neuroblast proliferation" NARROW [] synonym: "suppression of neuroblast proliferation" EXACT [] is_a: GO:0050768 ! negative regulation of neurogenesis is_a: GO:1902692 ! regulation of neuroblast proliferation is_a: GO:2000178 ! negative regulation of neural precursor cell proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0007405 ! negatively regulates neuroblast proliferation relationship: RO:0002212 GO:0007405 ! negatively regulates neuroblast proliferation [Term] id: GO:0007407 name: neuroblast activation namespace: biological_process def: "A change in the morphology or behavior of a neuroblast resulting from exposure to an activating factor such as a cellular or soluble ligand." [GOC:go_curators, GOC:mtg_sensu] is_a: BFO:0000003 is_a: GO:0001775 ! cell activation intersection_of: GO:0001775 ! cell activation intersection_of: RO:0004009 CL:0000031 ! has primary input neuroblast (sensu Vertebrata) relationship: BFO:0000050 GO:0048699 ! part of generation of neurons relationship: RO:0004009 CL:0000031 ! has primary input neuroblast (sensu Vertebrata) [Term] id: GO:0007409 name: axonogenesis namespace: biological_process def: "De novo generation of a long process of a neuron, including the terminal branched region. Refers to the morphogenesis or creation of shape or form of the developing axon, which carries efferent (outgoing) action potentials from the cell body towards target cells." [GOC:dph, GOC:jid, GOC:pg, GOC:pr, ISBN:0198506732] comment: Note that 'axonogenesis' differs from 'axon development' in that the latter also covers other processes, such as axon regeneration (regrowth after loss or damage, not necessarily of the whole axon). synonym: "axon growth" NARROW [] synonym: "axon morphogenesis" EXACT [GOC:bf, PMID:23517308] synonym: "neuron long process generation" EXACT systematic_synonym [] is_a: GO:0048812 ! neuron projection morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 GO:0030424 ! results in morphogenesis of axon relationship: BFO:0000050 GO:0048667 ! part of cell morphogenesis involved in neuron differentiation relationship: BFO:0000050 GO:0061564 ! part of axon development relationship: RO:0002298 GO:0030424 ! results in morphogenesis of axon [Term] id: GO:0007416 name: synapse assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form a synapse. This process ends when the synapse is mature (functional)." [GOC:mah] subset: goslim_synapse synonym: "synapse biogenesis" EXACT [GOC:mah] synonym: "synaptogenesis" EXACT [GOC:mah] xref: Wikipedia:Synaptogenesis is_a: GO:0034329 ! cell junction assembly is_a: GO:0050808 ! synapse organization intersection_of: GO:0009987 ! cellular process intersection_of: RO:0002588 GO:0045202 ! results in assembly of synapse relationship: BFO:0000050 GO:0007399 ! part of nervous system development relationship: RO:0002588 GO:0045202 ! results in assembly of synapse [Term] id: GO:0007417 name: central nervous system development namespace: biological_process def: "The process whose specific outcome is the progression of the central nervous system over time, from its formation to the mature structure. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain and spinal cord. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord." [GOC:bf, GOC:jid, ISBN:0582227089] synonym: "CNS development" EXACT [] xref: Wikipedia:Neural_development is_a: GO:0048731 ! system development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0001017 ! results in development of central nervous system relationship: BFO:0000050 GO:0007399 ! part of nervous system development relationship: RO:0002162 NCBITaxon:33213 ! in taxon Bilateria relationship: RO:0002296 UBERON:0001017 ! results in development of central nervous system [Term] id: GO:0007418 name: ventral midline development namespace: biological_process def: "The process whose specific outcome is the progression of the ventral midline over time, from its formation to the mature structure. In protostomes (such as insects, snails and worms) as well as deuterostomes (vertebrates), the midline is an embryonic region that functions in patterning of the adjacent nervous tissue. The ventral midline in insects is a cell population extending along the ventral surface of the embryo and is the region from which cells detach to form the ventrally located nerve cords. In vertebrates, the midline is originally located dorsally. During development, it folds inwards and becomes the ventral part of the dorsally located neural tube and is then called the ventral midline, or floor plate." [GOC:bf, GOC:go_curators, PMID:12075342] is_a: GO:0048856 ! anatomical structure development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0009571 ! results in development of ventral midline relationship: BFO:0000050 GO:0007417 ! part of central nervous system development relationship: RO:0002296 UBERON:0009571 ! results in development of ventral midline [Term] id: GO:0007420 name: brain development namespace: biological_process def: "The process whose specific outcome is the progression of the brain over time, from its formation to the mature structure. Brain development begins with patterning events in the neural tube and ends with the mature structure that is the center of thought and emotion. The brain is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)." [GOC:dph, GOC:jid, GOC:tb, UBERON:0000955] is_a: GO:0048513 ! animal organ development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0000955 ! results in development of brain relationship: BFO:0000050 GO:0007417 ! part of central nervous system development relationship: BFO:0000050 GO:0060322 ! part of head development relationship: RO:0002296 UBERON:0000955 ! results in development of brain [Term] id: GO:0007422 name: peripheral nervous system development namespace: biological_process def: "The process whose specific outcome is the progression of the peripheral nervous system over time, from its formation to the mature structure. The peripheral nervous system is one of the two major divisions of the nervous system. Nerves in the PNS connect the central nervous system (CNS) with sensory organs, other organs, muscles, blood vessels and glands." [GOC:go_curators, UBERON:0000010] is_a: GO:0048731 ! system development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0000010 ! results in development of peripheral nervous system relationship: BFO:0000050 GO:0007399 ! part of nervous system development relationship: RO:0002296 UBERON:0000010 ! results in development of peripheral nervous system [Term] id: GO:0007423 name: sensory organ development namespace: biological_process def: "The process whose specific outcome is the progression of sensory organs over time, from its formation to the mature structure." [GOC:go_curators] subset: goslim_drosophila synonym: "sense organ development" EXACT [GOC:dph] is_a: GO:0048513 ! animal organ development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0000020 ! results in development of sense organ relationship: RO:0002162 NCBITaxon:6072 ! in taxon Eumetazoa relationship: RO:0002296 UBERON:0000020 ! results in development of sense organ [Term] id: GO:0007424 name: open tracheal system development namespace: biological_process def: "The process whose specific outcome is the progression of an open tracheal system over time, from its formation to the mature structure. An open tracheal system is a respiratory system, a branched network of epithelial tubes that supplies oxygen to target tissues via spiracles. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:8625828] comment: See also the fly_anatomy.ontology term 'tracheal system ; FBbt:00005024'. is_a: GO:0060541 ! respiratory system development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0005155 ! results in development of open tracheal system relationship: RO:0002296 UBERON:0005155 ! results in development of open tracheal system [Term] id: GO:0007431 name: salivary gland development namespace: biological_process def: "The process whose specific outcome is the progression of the salivary gland over time, from its formation to the mature structure. Salivary glands include any of the saliva-secreting exocrine glands of the oral cavity." [GOC:jid, UBERON:0001044] subset: goslim_drosophila is_a: GO:0048732 ! gland development intersection_of: GO:0048732 ! gland development intersection_of: RO:0002296 UBERON:0001044 ! results in development of saliva-secreting gland relationship: BFO:0000050 GO:0035272 ! part of exocrine system development relationship: RO:0002296 UBERON:0001044 ! results in development of saliva-secreting gland [Term] id: GO:0007435 name: salivary gland morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the salivary gland are generated and organized." [GOC:jid] is_a: GO:0022612 ! gland morphogenesis intersection_of: GO:0022612 ! gland morphogenesis intersection_of: RO:0002298 UBERON:0001044 ! results in morphogenesis of saliva-secreting gland relationship: BFO:0000050 GO:0007431 ! part of salivary gland development relationship: RO:0002298 UBERON:0001044 ! results in morphogenesis of saliva-secreting gland [Term] id: GO:0007438 name: oenocyte development namespace: biological_process def: "The process whose specific outcome is the progression of the oenocyte over time, from its formation to the mature structure. The oenocytes are large secretory cells found in clusters underlying the epidermis of larval abdominal segments." [GOC:bf, PMID:11171397] is_a: GO:0048468 ! cell development intersection_of: GO:0032502 ! developmental process intersection_of: RO:0002296 CL:0000487 ! results in development of oenocyte relationship: BFO:0000050 GO:0001742 ! part of oenocyte differentiation relationship: RO:0002296 CL:0000487 ! results in development of oenocyte [Term] id: GO:0007439 name: ectodermal digestive tract development namespace: biological_process def: "The process whose specific outcome is the progression of the ectodermal digestive tract over time, from its formation to the mature structure. The ectodermal digestive tract includes those portions that are derived from ectoderm." [GOC:curators] synonym: "ectodermal gut development" RELATED [GOC:dph] is_a: GO:0048729 ! tissue morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002297 UBERON:0004906 ! results in formation of anatomical entity ectodermal part of digestive tract relationship: BFO:0000050 GO:0048565 ! part of digestive tract development relationship: RO:0002297 UBERON:0004906 ! results in formation of anatomical entity ectodermal part of digestive tract [Term] id: GO:0007440 name: foregut morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the foregut are generated and organized." [GOC:jid] is_a: BFO:0000003 is_a: GO:0009653 ! anatomical structure morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0001041 ! results in morphogenesis of foregut relationship: BFO:0000050 GO:0048546 ! part of digestive tract morphogenesis relationship: RO:0002298 UBERON:0001041 ! results in morphogenesis of foregut [Term] id: GO:0007442 name: hindgut morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the hindgut are generated and organized." [GOC:jid] is_a: BFO:0000003 is_a: GO:0009653 ! anatomical structure morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0001046 ! results in morphogenesis of hindgut relationship: BFO:0000050 GO:0048546 ! part of digestive tract morphogenesis relationship: BFO:0000050 GO:0061525 ! part of hindgut development relationship: RO:0002298 UBERON:0001046 ! results in morphogenesis of hindgut [Term] id: GO:0007443 name: Malpighian tubule morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the Malpighian tubule are generated and organized. This process takes place entirely during the embryonic phase. A Malpighian tubule is a fine, thin-walled excretory tubule in insects which leads into the posterior part of the gut." [GOC:bf, ISBN:0582227089] comment: See also the fly_anatomy.ontology term 'Malpighian tubule ; FBbt:00005786'. is_a: GO:0048598 ! embryonic morphogenesis is_a: GO:0061333 ! renal tubule morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0001054 ! results in morphogenesis of Malpighian tubule relationship: BFO:0000050 GO:0048619 ! part of embryonic hindgut morphogenesis relationship: BFO:0000050 GO:0072002 ! part of Malpighian tubule development relationship: RO:0002298 UBERON:0001054 ! results in morphogenesis of Malpighian tubule [Term] id: GO:0007444 name: imaginal disc development namespace: biological_process def: "The process whose specific outcome is the progression of the imaginal disc over time, from its formation to the metamorphosis to form adult structures. Imaginal discs are epithelial infoldings in the larvae of holometabolous insects that develop into adult structures (legs, antennae, wings, etc.)." [GOC:bf, ISBN:0879694238] is_a: GO:0048513 ! animal organ development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0000939 ! results in development of imaginal disc relationship: RO:0002296 UBERON:0000939 ! results in development of imaginal disc [Term] id: GO:0007446 name: imaginal disc growth namespace: biological_process def: "The increase in mass of imaginal discs by cell proliferation prior to metamorphosis. Imaginal discs are epithelial infoldings in the larvae of holometabolous insects that develop into adult structures (legs, antennae, wings, etc.) during metamorphosis from larval to adult form." [GOC:bf, GOC:jid, PMID:10679387] is_a: BFO:0000003 is_a: GO:0048589 ! developmental growth intersection_of: GO:0048589 ! developmental growth intersection_of: RO:0002343 UBERON:0000939 ! results in growth of imaginal disc relationship: BFO:0000050 GO:0007444 ! part of imaginal disc development relationship: RO:0002343 UBERON:0000939 ! results in growth of imaginal disc [Term] id: GO:0007488 name: histoblast morphogenesis namespace: biological_process def: "The process in which the anatomical structures derived from the histoblast disc are generated and organized. This includes the transformation of histoblast cells into adult structures during pupal metamorphosis. Histoblast cells are cells founded in the embryo that are the progenitors to the adult abdomen." [GOC:bf, ISBN:0879694238] synonym: "histoblast metamorphosis" EXACT [] is_a: GO:0000902 ! cell morphogenesis is_a: GO:0007560 ! imaginal disc morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 CL:0000373 ! results in morphogenesis of histoblast relationship: RO:0002298 CL:0000373 ! results in morphogenesis of histoblast [Term] id: GO:0007492 name: endoderm development namespace: biological_process def: "The process whose specific outcome is the progression of the endoderm over time, from its formation to the mature structure. The endoderm is the innermost germ layer that develops into the gastrointestinal tract, the lungs and associated tissues." [GOC:dph, GOC:tb] is_a: GO:0009888 ! tissue development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0000925 ! results in development of endoderm relationship: RO:0002296 UBERON:0000925 ! results in development of endoderm [Term] id: GO:0007494 name: midgut development namespace: biological_process def: "The process whose specific outcome is the progression of the midgut over time, from its formation to the mature structure. The midgut is the middle part of the alimentary canal from the stomach, or entrance of the bile duct, to, or including, the large intestine." [GOC:jid, UBERON:0001045] is_a: GO:0048565 ! digestive tract development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0001045 ! results in development of midgut relationship: RO:0002296 UBERON:0001045 ! results in development of midgut [Term] id: GO:0007498 name: mesoderm development namespace: biological_process def: "The process whose specific outcome is the progression of the mesoderm over time, from its formation to the mature structure. The mesoderm is the middle germ layer that develops into muscle, bone, cartilage, blood and connective tissue." [GOC:dph, GOC:tb] subset: goslim_drosophila is_a: GO:0009888 ! tissue development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0000926 ! results in development of mesoderm relationship: RO:0002296 UBERON:0000926 ! results in development of mesoderm [Term] id: GO:0007506 name: gonadal mesoderm development namespace: biological_process def: "The process whose specific outcome is the progression of the gonadal mesoderm over time, from its formation to the mature structure. The gonadal mesoderm is the middle layer of the three primary germ layers of the embryo which will go on to form the gonads of the organism." [GOC:ai] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0007498 ! mesoderm development is_a: GO:0060485 ! mesenchyme development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0003855 ! results in development of gonad mesenchyme relationship: BFO:0000050 GO:0008406 ! part of gonad development relationship: RO:0002296 UBERON:0003855 ! results in development of gonad mesenchyme [Term] id: GO:0007507 name: heart development namespace: biological_process def: "The process whose specific outcome is the progression of the heart over time, from its formation to the mature structure. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood." [GOC:jid, UBERON:0000948] synonym: "cardiac development" RELATED [] synonym: "dorsal vessel development" NARROW [] xref: Wikipedia:Heart_development is_a: GO:0048513 ! animal organ development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0007100 ! results in development of primary circulatory organ relationship: BFO:0000050 GO:0072359 ! part of circulatory system development relationship: RO:0002296 UBERON:0007100 ! results in development of primary circulatory organ [Term] id: GO:0007516 name: hemocyte development namespace: biological_process def: "The process whose specific outcome is the progression of the hemocyte over time, from its formation to the mature structure. Hemocytes are blood cells associated with a hemocoel (the cavity containing most of the major organs of the arthropod body) which are involved in defense and clotting of hemolymph, but not involved in transport of oxygen." [GOC:bf, GOC:mtg_sensu] synonym: "arthropod blood cell development" EXACT [] is_a: GO:0030097 ! hemopoiesis intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 CL:0000387 ! results in development of hemocyte (sensu Arthropoda) relationship: BFO:0000050 GO:0042386 ! part of hemocyte differentiation relationship: RO:0002296 CL:0000387 ! results in development of hemocyte (sensu Arthropoda) [Term] id: GO:0007517 name: muscle organ development namespace: biological_process def: "The process whose specific outcome is the progression of the muscle over time, from its formation to the mature structure. The muscle is an organ consisting of a tissue made up of various elongated cells that are specialized to contract and thus to produce movement and mechanical work." [GOC:jid, ISBN:0198506732] is_a: GO:0048513 ! animal organ development is_a: GO:0061061 ! muscle structure development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0001630 ! results in development of muscle organ relationship: RO:0002296 UBERON:0001630 ! results in development of muscle organ [Term] id: GO:0007519 name: skeletal muscle tissue development namespace: biological_process def: "The developmental sequence of events leading to the formation of adult skeletal muscle tissue. The main events are: the fusion of myoblasts to form myotubes that increase in size by further fusion to them of myoblasts, the formation of myofibrils within their cytoplasm and the establishment of functional neuromuscular junctions with motor neurons. At this stage they can be regarded as mature muscle fibers." [GOC:mtg_muscle] synonym: "myogenesis" RELATED [] is_a: GO:0014706 ! striated muscle tissue development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0001134 ! results in development of skeletal muscle tissue relationship: BFO:0000050 GO:0060538 ! part of skeletal muscle organ development relationship: RO:0002296 UBERON:0001134 ! results in development of skeletal muscle tissue [Term] id: GO:0007528 name: neuromuscular junction development namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a neuromuscular junction." [GOC:mtg_OBO2OWL_2013] synonym: "neuromuscular junction organization" EXACT [] synonym: "neuromuscular junction stability" RELATED [GOC:pr] synonym: "NMJ stability" RELATED [GOC:pr] is_a: GO:0050808 ! synapse organization intersection_of: GO:0016043 ! cellular component organization intersection_of: RO:0002592 GO:0031594 ! results in organization of neuromuscular junction relationship: RO:0002592 GO:0031594 ! results in organization of neuromuscular junction [Term] id: GO:0007530 name: sex determination namespace: biological_process def: "Any process that establishes and transmits the specification of sexual status of an individual organism." [ISBN:0198506732] xref: Wikipedia:Sex-determination_system is_a: GO:0003006 ! developmental process involved in reproduction [Term] id: GO:0007548 name: sex differentiation namespace: biological_process def: "The establishment of the sex of an organism by physical differentiation." [GOC:ai] xref: Wikipedia:Sexual_differentiation is_a: GO:0003006 ! developmental process involved in reproduction [Term] id: GO:0007552 name: metamorphosis namespace: biological_process def: "A biological process in which an animal physically develops after birth or hatching, involving a conspicuous and relatively abrupt change in the animal's form or structure. Examples include the change from tadpole to frog, and the change from larva to adult. An example of this is found in Drosophila melanogaster." [GOC:sensu, ISBN:0198506732, ISBN:0721662544] xref: Wikipedia:Metamorphosis is_a: GO:0007275 ! multicellular organism development property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0007553 name: regulation of ecdysteroid metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving ecdysteroids, a group of polyhydroxylated ketosteroids which initiate post-embryonic development, including the metamorphosis of immature forms and the development of the reproductive system and the maturation of oocytes in adult females." [ISBN:0198506732] synonym: "regulation of ecdysteroid metabolism" EXACT [] is_a: GO:0010565 ! regulation of ketone metabolic process is_a: GO:0019218 ! regulation of steroid metabolic process is_a: GO:0032350 ! regulation of hormone metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0045455 ! regulates ecdysteroid metabolic process relationship: RO:0002211 GO:0045455 ! regulates ecdysteroid metabolic process [Term] id: GO:0007554 name: regulation of ecdysteroid biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of ecdysteroids." [GOC:go_curators] synonym: "regulation of ecdysteroid anabolism" EXACT [] synonym: "regulation of ecdysteroid biosynthesis" EXACT [] synonym: "regulation of ecdysteroid formation" EXACT [] synonym: "regulation of ecdysteroid synthesis" EXACT [] is_a: GO:0007553 ! regulation of ecdysteroid metabolic process is_a: GO:0010566 ! regulation of ketone biosynthetic process is_a: GO:0090030 ! regulation of steroid hormone biosynthetic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0045456 ! regulates ecdysteroid biosynthetic process relationship: RO:0002211 GO:0045456 ! regulates ecdysteroid biosynthetic process [Term] id: GO:0007555 name: regulation of ecdysteroid secretion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the regulated release of ecdysteroid from a cell." [GOC:go_curators] is_a: GO:2000831 ! regulation of steroid hormone secretion intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0045457 ! regulates ecdysteroid secretion relationship: RO:0002211 GO:0045457 ! regulates ecdysteroid secretion property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0007557 name: regulation of juvenile hormone biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of juvenile hormone." [GOC:go_curators] synonym: "regulation of juvenile hormone anabolism" EXACT [] synonym: "regulation of juvenile hormone biosynthesis" EXACT [] synonym: "regulation of juvenile hormone formation" EXACT [] synonym: "regulation of juvenile hormone synthesis" EXACT [] is_a: GO:0019747 ! regulation of isoprenoid metabolic process is_a: GO:0046885 ! regulation of hormone biosynthetic process is_a: GO:0046890 ! regulation of lipid biosynthetic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0006718 ! regulates juvenile hormone biosynthetic process relationship: RO:0002211 GO:0006718 ! regulates juvenile hormone biosynthetic process property_value: RO:0002161 NCBITaxon:4895 [Term] id: GO:0007558 name: regulation of juvenile hormone secretion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of juvenile hormone secretion." [GOC:go_curators] is_a: GO:0032368 ! regulation of lipid transport is_a: GO:0044060 ! regulation of endocrine process is_a: GO:0046883 ! regulation of hormone secretion intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0045443 ! regulates juvenile hormone secretion relationship: RO:0002211 GO:0045443 ! regulates juvenile hormone secretion property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0007560 name: imaginal disc morphogenesis namespace: biological_process def: "The process in which the anatomical structures derived from an imaginal disc are generated and organized. The imaginal discs are epithelial infoldings in the larvae of holometabolous insects that develop into adult appendages (legs, antennae, wings, etc.) during metamorphosis from larval to adult form." [GOC:jid] synonym: "imaginal disc metamorphosis" EXACT [] is_a: GO:0009887 ! animal organ morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0000939 ! results in morphogenesis of imaginal disc relationship: BFO:0000050 GO:0007444 ! part of imaginal disc development relationship: BFO:0000050 GO:0007552 ! part of metamorphosis relationship: BFO:0000050 GO:0048707 ! part of instar larval or pupal morphogenesis relationship: RO:0002298 UBERON:0000939 ! results in morphogenesis of imaginal disc [Term] id: GO:0007565 name: female pregnancy namespace: biological_process def: "The set of physiological processes that allow an embryo or foetus to develop within the body of a female animal. It covers the time from fertilization of a female ovum by a male spermatozoon until birth." [ISBN:0192800825] subset: goslim_chembl synonym: "carrying of young" RELATED [] synonym: "gestation" EXACT [] xref: Wikipedia:Gestation is_a: GO:0044703 ! multi-organism reproductive process is_a: GO:0044706 ! multi-multicellular organism process relationship: RO:0002162 NCBITaxon:40674 ! in taxon Mammalia [Term] id: GO:0007566 name: embryo implantation namespace: biological_process def: "Attachment of the blastocyst to the uterine lining." [GOC:isa_complete, PMID:10882512] synonym: "blastocyst implantation" EXACT [] is_a: GO:0022414 ! reproductive process relationship: BFO:0000050 GO:0007275 ! part of multicellular organism development relationship: BFO:0000050 GO:0007565 ! part of female pregnancy [Term] id: GO:0007585 name: respiratory gaseous exchange by respiratory system namespace: biological_process def: "The process of gaseous exchange between an organism and its environment. In plants, microorganisms, and many small animals, air or water makes direct contact with the organism's cells or tissue fluids, and the processes of diffusion supply the organism with dioxygen (O2) and remove carbon dioxide (CO2). In larger animals the efficiency of gaseous exchange is improved by specialized respiratory organs, such as lungs and gills, which are ventilated by breathing mechanisms." [ISBN:0198506732] subset: goslim_chembl synonym: "breathing" BROAD [] synonym: "respiration" BROAD [] is_a: GO:0032501 ! multicellular organismal process property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0007586 name: digestion namespace: biological_process def: "The whole of the physical, chemical, and biochemical processes carried out by multicellular organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism." [GOC:isa_complete, ISBN:0198506732] subset: goslim_chembl subset: goslim_pir xref: Reactome:R-HSA-8935690 "Digestion" xref: Wikipedia:Digestion is_a: GO:0032501 ! multicellular organismal process property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0007588 name: excretion namespace: biological_process def: "The elimination by an organism of the waste products that arise as a result of metabolic activity. These products include water, carbon dioxide (CO2), and nitrogenous compounds." [ISBN:0192801023] subset: gocheck_do_not_annotate subset: goslim_pir xref: Wikipedia:Excretion is_a: GO:0003008 ! system process property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/22368" xsd:anyURI property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0007589 name: body fluid secretion namespace: biological_process def: "The controlled release of a fluid by a cell or tissue in an animal." [GOC:ai, GOC:dph, GOC:mah, GOC:tb] is_a: GO:0046903 ! secretion is_a: GO:0050878 ! regulation of body fluid levels [Term] id: GO:0007595 name: lactation namespace: biological_process def: "The regulated release of milk from the mammary glands and the period of time that a mother lactates to feed her young." [ISBN:0198506732] synonym: "milk secretion" EXACT [GOC:pr] xref: Wikipedia:Lactation is_a: GO:0007589 ! body fluid secretion relationship: BFO:0000050 GO:0030879 ! part of mammary gland development relationship: BFO:0000051 GO:0060156 ! has part milk ejection reflex [Term] id: GO:0007596 name: blood coagulation namespace: biological_process def: "The sequential process in which the multiple coagulation factors of the blood interact, ultimately resulting in the formation of an insoluble fibrin clot; it may be divided into three stages: stage 1, the formation of intrinsic and extrinsic prothrombin converting principle; stage 2, the formation of thrombin; stage 3, the formation of stable fibrin polymers." [PMID:30700128] synonym: "blood clotting" EXACT [] xref: Reactome:R-HSA-109582 "Hemostasis" xref: Wikipedia:Coagulation is_a: BFO:0000003 is_a: GO:0007599 ! hemostasis is_a: GO:0050817 ! coagulation intersection_of: GO:0050817 ! coagulation intersection_of: RO:0002588 UBERON:0010210 ! results in assembly of blood clot relationship: BFO:0000050 GO:0042060 ! part of wound healing relationship: RO:0002588 UBERON:0010210 ! results in assembly of blood clot [Term] id: GO:0007599 name: hemostasis namespace: biological_process def: "The stopping of bleeding (loss of body fluid) or the arrest of the circulation to an organ or part." [ISBN:0198506732] xref: Wikipedia:Hemostasis is_a: GO:0050878 ! regulation of body fluid levels [Term] id: GO:0007600 name: sensory perception namespace: biological_process def: "The series of events required for an organism to receive a sensory stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process." [GOC:ai, GOC:dph] subset: goslim_drosophila xref: Reactome:R-HSA-9709957 "Sensory Perception" xref: Wikipedia:Perception is_a: GO:0050877 ! nervous system process [Term] id: GO:0007601 name: visual perception namespace: biological_process def: "The series of events required for an organism to receive a visual stimulus, convert it to a molecular signal, and recognize and characterize the signal. Visual stimuli are detected in the form of photons and are processed to form an image." [GOC:ai] synonym: "sense of sight" EXACT [] synonym: "sensory visual perception" EXACT [] synonym: "vision" EXACT [] xref: Wikipedia:Visual_perception is_a: GO:0050953 ! sensory perception of light stimulus [Term] id: GO:0007605 name: sensory perception of sound namespace: biological_process def: "The series of events required for an organism to receive an auditory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Sonic stimuli are detected in the form of vibrations and are processed to form a sound." [GOC:ai] synonym: "hearing" EXACT [] synonym: "perception of sound" EXACT [] xref: Reactome:R-HSA-9659379 "Sensory processing of sound" xref: Wikipedia:Hearing_(sense) is_a: GO:0050954 ! sensory perception of mechanical stimulus [Term] id: GO:0007606 name: sensory perception of chemical stimulus namespace: biological_process def: "The series of events required for an organism to receive a sensory chemical stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process." [GOC:ai] synonym: "chemosensory perception" EXACT [] is_a: GO:0007600 ! sensory perception [Term] id: GO:0007608 name: sensory perception of smell namespace: biological_process def: "The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. This is a neurological process." [GOC:ai] synonym: "olfaction" EXACT [] synonym: "scent perception" EXACT [] synonym: "sense of smell" EXACT [] synonym: "smell perception" EXACT [] xref: Wikipedia:Olfaction is_a: GO:0007606 ! sensory perception of chemical stimulus [Term] id: GO:0007610 name: behavior namespace: biological_process def: "The internally coordinated responses (actions or inactions) of animals (individuals or groups) to internal or external stimuli, via a mechanism that involves nervous system activity." [GOC:ems, GOC:jl, ISBN:0395448956, PMID:20160973] comment: 1. Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation reviews.\n2. While a broader definition of behavior encompassing plants and single cell organisms would be justified on the basis of some usage (see PMID:20160973 for discussion), GO uses a tight definition that limits behavior to animals and to responses involving the nervous system, excluding plant responses that GO classifies under development, and responses of unicellular organisms that has general classifications for covering the responses of cells in multicellular organisms (e.g. cell chemotaxis). subset: gocheck_do_not_annotate subset: goslim_agr subset: goslim_flybase_ribbon synonym: "behavioral response to stimulus" EXACT [] synonym: "behaviour" EXACT [] synonym: "behavioural response to stimulus" EXACT [] synonym: "single-organism behavior" RELATED [] xref: Wikipedia:Behavior is_a: GO:0032501 ! multicellular organismal process disjoint_from: GO:0032502 ! developmental process relationship: RO:0002162 NCBITaxon:33208 ! in taxon Metazoa relationship: RO:0002608 UBERON:0001016 ! process has causal agent nervous system creation_date: 2012-09-20T14:06:08Z [Term] id: GO:0007611 name: learning or memory namespace: biological_process def: "The acquisition and processing of information and/or the storage and retrieval of this information over time." [GOC:jid, PMID:8938125] is_a: GO:0007610 ! behavior is_a: GO:0050890 ! cognition [Term] id: GO:0007612 name: learning namespace: biological_process def: "Any process in an organism in which a relatively long-lasting adaptive behavioral change occurs as the result of experience." [ISBN:0582227089, ISBN:0721662544] xref: Wikipedia:Learning is_a: GO:0007611 ! learning or memory [Term] id: GO:0007613 name: memory namespace: biological_process def: "The activities involved in the mental information processing system that receives (registers), modifies, stores, and retrieves informational stimuli. The main stages involved in the formation and retrieval of memory are encoding (processing of received information by acquisition), storage (building a permanent record of received information as a result of consolidation) and retrieval (calling back the stored information and use it in a suitable way to execute a given task)." [GOC:curators, ISBN:0582227089] xref: Wikipedia:Memory is_a: GO:0007611 ! learning or memory [Term] id: GO:0007617 name: mating behavior namespace: biological_process def: "The behavioral interactions between organisms for the purpose of mating, or sexual reproduction resulting in the formation of zygotes." [GOC:ai, GOC:dph] synonym: "mating behaviour" EXACT [] xref: Wikipedia:Mating_behaviour is_a: GO:0019098 ! reproductive behavior [Term] id: GO:0007620 name: copulation namespace: biological_process def: "The act of sexual union between male and female, involving the transfer of sperm." [ISBN:0721662544] is_a: GO:0007617 ! mating behavior [Term] id: GO:0007626 name: locomotory behavior namespace: biological_process def: "The specific movement from place to place of an organism in response to external or internal stimuli. Locomotion of a whole organism in a manner dependent upon some combination of that organism's internal state and external conditions." [GOC:dph] subset: goslim_drosophila synonym: "behavior via locomotion" EXACT [] synonym: "locomotion in response to stimulus" EXACT [] synonym: "locomotory behavioral response to stimulus" EXACT [] synonym: "locomotory behaviour" EXACT [] synonym: "locomotory behavioural response to stimulus" EXACT [] is_a: GO:0007610 ! behavior [Term] id: GO:0007635 name: chemosensory behavior namespace: biological_process def: "Behavior that is dependent upon the sensation of chemicals." [GOC:go_curators] synonym: "behavioral response to chemical stimulus" EXACT [] synonym: "behavioural response to chemical stimulus" EXACT [] synonym: "chemosensory behaviour" EXACT [] is_a: GO:0007610 ! behavior relationship: BFO:0000050 GO:0042221 ! part of response to chemical [Term] id: GO:0008015 name: blood circulation namespace: biological_process def: "The flow of blood through the body of an animal, enabling the transport of nutrients to the tissues and the removal of waste products." [GOC:mtg_heart, ISBN:0192800825] subset: goslim_pir synonym: "hemolymph circulation" RELATED [] is_a: GO:0003013 ! circulatory system process property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0008016 name: regulation of heart contraction namespace: biological_process def: "Any process that modulates the frequency, rate or extent of heart contraction. Heart contraction is the process in which the heart decreases in volume in a characteristic way to propel blood through the body." [GOC:dph, GOC:go_curators, GOC:tb] synonym: "regulation of cardiac contraction" EXACT [] is_a: GO:1903522 ! regulation of blood circulation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0060047 ! regulates heart contraction relationship: RO:0002211 GO:0060047 ! regulates heart contraction property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0008017 name: microtubule binding namespace: molecular_function def: "Binding to a microtubule, a filament composed of tubulin monomers." [GOC:krc] synonym: "microtubule severing activity" RELATED [] synonym: "microtubule/chromatin interaction" RELATED [] xref: Reactome:R-HSA-9614343 "Viral UL47:UL48 Proteins Bind HCMV Tegumented Virion to Host Microtuble and Dynein complexs" is_a: GO:0015631 ! tubulin binding intersection_of: GO:0005488 ! binding intersection_of: RO:0004009 GO:0005874 ! has primary input microtubule relationship: RO:0004009 GO:0005874 ! has primary input microtubule [Term] id: GO:0008028 name: monocarboxylic acid transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of monocarboxylic acids from one side of a membrane to the other. A monocarboxylic acid is an organic acid with one COOH group." [GOC:ai] synonym: "monocarboxylate carrier" NARROW [] synonym: "prostaglandin/thromboxane transporter activity" NARROW [] xref: Reactome:R-HSA-429749 "SLC5A8 (SMCT) co-transports monocarboxylates and Na+ from extracellular region to cytosol" xref: Reactome:R-HSA-433698 "SLC16A3,7,8 cotransport monocarboxylates, H+ from extracellular region to cytosol" xref: Reactome:R-HSA-5624211 "Defective SLC16A1 does not cotransport monocarboxylates, H+ from extracellular region to cytosol" xref: Reactome:R-HSA-9645220 "SLC16A1:BSG cotransports monocarboxylates, H+ from extracellular region to cytosol" is_a: GO:0046943 ! carboxylic acid transmembrane transporter activity intersection_of: GO:0022857 ! transmembrane transporter activity intersection_of: RO:0004009 CHEBI:25384 ! has primary input relationship: BFO:0000050 GO:0015718 ! part of monocarboxylic acid transport relationship: RO:0004009 CHEBI:25384 ! has primary input [Term] id: GO:0008053 name: mitochondrial fusion namespace: biological_process def: "Merging of two or more mitochondria within a cell to form a single compartment." [PMID:11038192, PMID:12052774] synonym: "mitochondrial membrane fusion" RELATED [] synonym: "mitochondrion fusion" EXACT [] is_a: GO:0007005 ! mitochondrion organization is_a: GO:0048284 ! organelle fusion intersection_of: GO:0009987 ! cellular process intersection_of: RO:0012008 GO:0005739 ! results in fusion of mitochondrion relationship: RO:0012008 GO:0005739 ! results in fusion of mitochondrion property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/23133" xsd:anyURI creation_date: 2015-01-21T06:58:18Z [Term] id: GO:0008066 name: glutamate receptor activity namespace: molecular_function def: "Combining with glutamate and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:ai, GOC:signaling] is_a: BFO:0000003 is_a: GO:0004888 ! transmembrane signaling receptor activity intersection_of: GO:0038023 ! signaling receptor activity intersection_of: RO:0004009 CHEBI:14321 ! has primary input relationship: BFO:0000051 GO:0016595 ! has part glutamate binding relationship: RO:0004009 CHEBI:14321 ! has primary input [Term] id: GO:0008076 name: voltage-gated potassium channel complex namespace: cellular_component def: "A protein complex that forms a transmembrane channel through which potassium ions may cross a cell membrane in response to changes in membrane potential." [GOC:mah] synonym: "voltage gated potassium channel complex" EXACT [] synonym: "voltage-dependent potassium channel complex" EXACT [] synonym: "voltage-sensitive potassium channel complex" EXACT [] xref: NIF_Subcellular:sao371494298 is_a: GO:0034705 ! potassium channel complex is_a: GO:0098797 ! plasma membrane protein complex intersection_of: GO:0032991 ! protein-containing complex intersection_of: RO:0002215 GO:0005249 ! capable of voltage-gated potassium channel activity relationship: RO:0002215 GO:0005249 ! capable of voltage-gated potassium channel activity [Term] id: GO:0008078 name: mesodermal cell migration namespace: biological_process def: "The orderly movement of mesodermal cells from one site to another." [GOC:ascb_2009, GOC:dph, GOC:mah, GOC:sat, GOC:tb, PMID:25119047] synonym: "mesoderm cell migration" EXACT [] is_a: BFO:0000003 is_a: GO:0001667 ! ameboidal-type cell migration intersection_of: GO:0016477 ! cell migration intersection_of: RO:0002565 CL:0000222 ! results in movement of mesodermal cell relationship: RO:0002565 CL:0000222 ! results in movement of mesodermal cell property_value: RO:0002161 NCBITaxon:4890 [Term] id: GO:0008088 name: axo-dendritic transport namespace: biological_process def: "The directed movement of organelles or molecules along microtubules in neuron projections." [ISBN:0815316194] subset: goslim_synapse synonym: "axon cargo transport" NARROW [] synonym: "axonal transport" NARROW [] synonym: "axoplasmic transport" NARROW [] xref: Wikipedia:Axoplasmic_transport is_a: GO:0010970 ! transport along microtubule intersection_of: GO:0046907 ! intracellular transport intersection_of: BFO:0000066 GO:0043005 ! occurs in neuron projection intersection_of: RO:0002341 GO:0005874 ! results in transport along microtubule relationship: BFO:0000066 GO:0043005 ! occurs in neuron projection relationship: RO:0002162 NCBITaxon:33208 ! in taxon Metazoa [Term] id: GO:0008089 name: anterograde axonal transport namespace: biological_process def: "The directed movement of organelles or molecules along microtubules from the cell body toward the cell periphery in nerve cell axons." [ISBN:0815316194] subset: goslim_synapse synonym: "anterograde axon cargo transport" EXACT [] is_a: GO:0098930 ! axonal transport intersection_of: GO:0006810 ! transport intersection_of: BFO:0000066 GO:1904115 ! occurs in axon cytoplasm intersection_of: RO:0002339 GO:0098793 ! has target end location presynapse intersection_of: RO:0002341 GO:0005874 ! results in transport along microtubule relationship: BFO:0000066 GO:1904115 ! occurs in axon cytoplasm relationship: RO:0002339 GO:0098793 ! has target end location presynapse [Term] id: GO:0008090 name: retrograde axonal transport namespace: biological_process def: "The directed movement of organelles or molecules along microtubules from the cell periphery toward the cell body in nerve cell axons." [ISBN:0815316194] subset: goslim_synapse synonym: "retrograde axon cargo transport" EXACT [] is_a: GO:0098930 ! axonal transport intersection_of: GO:0006810 ! transport intersection_of: BFO:0000066 GO:1904115 ! occurs in axon cytoplasm intersection_of: RO:0002338 GO:0098793 ! has target start location presynapse intersection_of: RO:0002341 GO:0005874 ! results in transport along microtubule relationship: BFO:0000066 GO:1904115 ! occurs in axon cytoplasm relationship: RO:0002338 GO:0098793 ! has target start location presynapse [Term] id: GO:0008092 name: cytoskeletal protein binding namespace: molecular_function def: "Binding to a protein component of a cytoskeleton (actin, microtubule, or intermediate filament cytoskeleton)." [GOC:mah] subset: goslim_agr subset: goslim_chembl subset: goslim_drosophila subset: goslim_flybase_ribbon subset: goslim_generic subset: goslim_mouse subset: goslim_prokaryote subset: goslim_yeast is_a: GO:0005515 ! protein binding [Term] id: GO:0008094 name: ATP-dependent activity, acting on DNA namespace: molecular_function def: "Catalytic activity that acts to modify DNA, driven by ATP hydrolysis." [GOC:pdt] synonym: "adenosinetriphosphatase (DNA-dependent)" EXACT [] synonym: "ATPase activity, acting on DNA" EXACT [] synonym: "ATPase, acting on DNA" EXACT [] synonym: "DNA dependent ATPase activity" EXACT [] synonym: "DNA-dependent adenosinetriphosphatase activity" EXACT [] synonym: "DNA-dependent ATPase activity" EXACT [] is_a: GO:0140097 ! catalytic activity, acting on DNA is_a: GO:0140657 ! ATP-dependent activity intersection_of: GO:0140097 ! catalytic activity, acting on DNA intersection_of: BFO:0000051 GO:0016887 ! has part ATP hydrolysis activity property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/20876" xsd:anyURI property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/21612" xsd:anyURI property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/21775" xsd:anyURI [Term] id: GO:0008104 name: intracellular protein localization namespace: biological_process def: "Any process in which a protein is transported to, or maintained in, a specific location." [GOC:ai] subset: goslim_drosophila synonym: "asymmetric protein localisation" RELATED [GOC:mah] synonym: "asymmetric protein localization" RELATED [] synonym: "cellular protein localisation" EXACT [GOC:mah] synonym: "cellular protein localization" EXACT [] synonym: "channel localizer activity" NARROW [GOC:mah] synonym: "establishment and maintenance of asymmetric protein localization" RELATED [] synonym: "establishment and maintenance of protein localization" RELATED [] synonym: "protein localisation" EXACT [GOC:mah] synonym: "protein localization" BROAD [] xref: Reactome:R-HSA-9609507 "Protein localization" is_a: BFO:0000003 is_a: GO:0033036 ! macromolecule localization relationship: RO:0004009 PR:000000001 ! has primary input protein property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/23112" xsd:anyURI [Term] id: GO:0008134 name: transcription factor binding namespace: molecular_function def: "Binding to a transcription factor, a protein required to initiate or regulate transcription." [ISBN:0198506732] comment: Note that this term should not be used for direct annotation. Please consider one of the more specific descendants, GO:0140297 ; DNA-binding transcription factor binding, GO:0140296 ; general transcription initiation factor binding or GO:0001221 ; transcription coregulator binding. subset: gocheck_do_not_annotate subset: goslim_agr subset: goslim_chembl subset: goslim_drosophila subset: goslim_metagenomics subset: goslim_yeast synonym: "TF binding" EXACT [] synonym: "transcription regulator binding" RELATED [] is_a: GO:0005515 ! protein binding property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/19354" xsd:anyURI [Term] id: GO:0008150 name: biological_process namespace: biological_process def: "A biological process is the execution of a genetically-encoded biological module or program. It consists of all the steps required to achieve the specific biological objective of the module. A biological process is accomplished by a particular set of molecular functions carried out by specific gene products (or macromolecular complexes), often in a highly regulated manner and in a particular temporal sequence." [GOC:pdt] comment: Note that, in addition to forming the root of the biological process ontology, this term is recommended for the annotation of gene products whose biological process is unknown. When this term is used for annotation, it indicates that no information was available about the biological process of the gene product annotated as of the date the annotation was made; the evidence code 'no data' (ND), is used to indicate this. subset: goslim_candida subset: goslim_chembl subset: goslim_metagenomics subset: goslim_pir subset: goslim_plant subset: goslim_pombe subset: goslim_yeast synonym: "biological process" EXACT [] synonym: "physiological process" EXACT [] synonym: "single organism process" RELATED [] synonym: "single-organism process" RELATED [] xref: Wikipedia:Biological_process is_a: BFO:0000015 property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/24968" xsd:anyURI creation_date: 2012-09-19T15:05:24Z [Term] id: GO:0008152 name: metabolic process namespace: biological_process def: "A cellular process consisting of the biochemical pathways by which a living organism transforms chemical substances. This includes including anabolism (biosynthetic process) and catabolism (catabolic process). Metabolic processes includes the transformation of small molecules, as well macromolecular processes such as DNA repair and replication, protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684] comment: Note that metabolic processes do not include single functions or processes such as protein-protein interactions, protein-nucleic acids, nor receptor-ligand interactions. subset: gocheck_do_not_annotate subset: goslim_chembl subset: goslim_euk_cellular_processes_ribbon subset: goslim_metagenomics subset: goslim_pir subset: goslim_plant subset: goslim_prokaryote_ribbon synonym: "metabolism" EXACT [] xref: Reactome:R-HSA-1430728 "Metabolism" xref: Wikipedia:Metabolism is_a: GO:0009987 ! cellular process disjoint_from: GO:0044848 ! biological phase disjoint_from: GO:0051179 ! localization property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/26424" xsd:anyURI property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/28932" xsd:anyURI creation_date: 2012-10-17T15:46:40Z [Term] id: GO:0008186 name: ATP-dependent activity, acting on RNA namespace: molecular_function def: "Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction requires the presence of RNA, and it drives another reaction." [GOC:jl] synonym: "ATPase activity, acting on RNA" EXACT [] synonym: "ATPase, acting on RNA" EXACT [] synonym: "RNA-dependent adenosinetriphosphatase activity" EXACT [] synonym: "RNA-dependent ATPase activity" EXACT [] xref: Reactome:R-HSA-9770847 "Spliceosomal P complex dissociates yielding the intron-containing complex (ILS) and the spliced mRNP (new)" xref: Reactome:R-HSA-9772351 "Disassembly of the Intron Lariat Spliceosome (new)" is_a: GO:0140657 ! ATP-dependent activity intersection_of: GO:0140657 ! ATP-dependent activity intersection_of: RO:0004009 CHEBI:33697 ! has primary input relationship: RO:0004009 CHEBI:33697 ! has primary input property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/20876" xsd:anyURI property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/21775" xsd:anyURI [Term] id: GO:0008188 name: neuropeptide receptor activity namespace: molecular_function def: "Combining with a neuropeptide to initiate a change in cell activity." [GOC:ai] is_a: GO:0008528 ! G protein-coupled peptide receptor activity relationship: BFO:0000050 GO:0007218 ! part of neuropeptide signaling pathway relationship: BFO:0000051 GO:0042923 ! has part neuropeptide binding property_value: RO:0002161 NCBITaxon:4751 [Term] id: GO:0008202 name: steroid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus." [ISBN:0198547684] synonym: "steroid metabolism" EXACT [] xref: Reactome:R-HSA-8957322 "Metabolism of steroids" xref: Wikipedia:Steroid_metabolism is_a: GO:0006629 ! lipid metabolic process intersection_of: GO:0008152 ! metabolic process intersection_of: RO:0004007 CHEBI:35341 ! has primary input or output relationship: RO:0004007 CHEBI:35341 ! has primary input or output [Term] id: GO:0008206 name: bile acid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving bile acids, a group of steroid carboxylic acids occurring in bile, where they are present as the sodium salts of their amides with glycine or taurine." [GOC:go_curators] synonym: "bile acid metabolism" EXACT [] xref: Reactome:R-HSA-194068 "Bile acid and bile salt metabolism" is_a: GO:0008202 ! steroid metabolic process is_a: GO:0032787 ! monocarboxylic acid metabolic process intersection_of: GO:0008152 ! metabolic process intersection_of: RO:0004007 CHEBI:36235 ! has primary input or output relationship: RO:0004007 CHEBI:36235 ! has primary input or output [Term] id: GO:0008207 name: C21-steroid hormone metabolic process namespace: biological_process def: "The chemical reactions and pathways involving C21-steroid hormones, steroid compounds containing 21 carbons which function as hormones." [GOC:ai] synonym: "C21-steroid hormone metabolism" EXACT [] is_a: GO:0008202 ! steroid metabolic process is_a: GO:0042445 ! hormone metabolic process intersection_of: GO:0008152 ! metabolic process intersection_of: RO:0004007 CHEBI:64600 ! has primary input or output relationship: RO:0004007 CHEBI:64600 ! has primary input or output property_value: RO:0002161 NCBITaxon:4895 [Term] id: GO:0008208 name: C21-steroid hormone catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of C21-steroid hormones, steroid compounds containing 21 carbons which function as hormones." [GOC:ai] synonym: "C21-steroid hormone breakdown" EXACT [] synonym: "C21-steroid hormone catabolism" EXACT [] synonym: "C21-steroid hormone degradation" EXACT [] is_a: GO:0006706 ! steroid catabolic process is_a: GO:0008207 ! C21-steroid hormone metabolic process is_a: GO:0042447 ! hormone catabolic process intersection_of: GO:0009056 ! catabolic process intersection_of: RO:0004009 CHEBI:64600 ! has primary input relationship: RO:0004009 CHEBI:64600 ! has primary input property_value: RO:0002161 NCBITaxon:4895 [Term] id: GO:0008211 name: glucocorticoid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving glucocorticoids, hormonal C21 corticosteroids synthesized from cholesterol. Glucocorticoids act primarily on carbohydrate and protein metabolism, and have anti-inflammatory effects." [ISBN:0198506732] synonym: "glucocorticoid metabolism" EXACT [] synonym: "glucocorticosteroid metabolic process" EXACT [] synonym: "glucocorticosteroid metabolism" EXACT [] is_a: GO:0008202 ! steroid metabolic process intersection_of: GO:0008152 ! metabolic process intersection_of: RO:0004007 CHEBI:24261 ! has primary input or output relationship: RO:0004007 CHEBI:24261 ! has primary input or output [Term] id: GO:0008212 name: mineralocorticoid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving mineralocorticoids, hormonal C21 corticosteroids synthesized from cholesterol. Mineralocorticoids act primarily on water and electrolyte balance." [ISBN:0198506732] synonym: "mineralocorticoid metabolism" EXACT [] is_a: GO:0008202 ! steroid metabolic process is_a: GO:0042445 ! hormone metabolic process intersection_of: GO:0008152 ! metabolic process intersection_of: RO:0004007 CHEBI:25354 ! has primary input or output relationship: RO:0004007 CHEBI:25354 ! has primary input or output property_value: RO:0002161 NCBITaxon:4895 [Term] id: GO:0008217 name: regulation of blood pressure namespace: biological_process def: "Any process that modulates the force with which blood travels through the circulatory system. The process is controlled by a balance of processes that increase pressure and decrease pressure." [GOC:dph, GOC:mtg_cardio, ISBN:0721643949] synonym: "blood pressure homeostasis" RELATED [] synonym: "blood pressure regulation" EXACT [] synonym: "control of blood pressure" RELATED [] xref: Wikipedia:Blood_pressure#Regulation is_a: GO:0065008 ! regulation of biological quality relationship: BFO:0000050 GO:0008015 ! part of blood circulation property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0008219 name: cell death namespace: biological_process def: "Any biological process that results in permanent cessation of all vital functions of a cell. A cell should be considered dead when any one of the following molecular or morphological criteria is met: (1) the cell has lost the integrity of its plasma membrane; (2) the cell, including its nucleus, has undergone complete fragmentation into discrete bodies (frequently referred to as apoptotic bodies). The cell corpse (or its fragments) may be engulfed by an adjacent cell in vivo, but engulfment of whole cells should not be considered a strict criteria to define cell death as, under some circumstances, live engulfed cells can be released from phagosomes (see PMID:18045538)." [GOC:mah, GOC:mtg_apoptosis, PMID:25236395] comment: This term should not be used for direct annotation, it is currently kept in GO as a placeholder for describing cell death phenotypes in uPHENO. When information is provided on a programmed cell death mechanism, annotations should be made to the appropriate descendant of 'cell death' (such as, but not limited to, GO:0097300 'programmed necrotic cell death' or GO:0006915 'apoptotic process'). Unintentional cell death, i.e. cell death caused by injury, ageing, or cell phenotypes observed as a result of a pathological mutation in an essential gene should NOT be annotated using GO terms. subset: gocheck_do_not_annotate synonym: "accidental cell death" RELATED [] synonym: "necrosis" RELATED [] is_a: GO:0009987 ! cellular process property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/24680" xsd:anyURI [Term] id: GO:0008227 name: G protein-coupled amine receptor activity namespace: molecular_function def: "Combining with an extracellular amine and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, GOC:dph] synonym: "amine receptor activity, G-protein coupled" EXACT [GOC:bf] synonym: "biogenic amine receptor" NARROW [] synonym: "G-protein coupled amine receptor activity" EXACT [] is_a: GO:0004930 ! G protein-coupled receptor activity intersection_of: GO:0004930 ! G protein-coupled receptor activity intersection_of: RO:0004009 CHEBI:32952 ! has primary input relationship: RO:0004009 CHEBI:32952 ! has primary input [Term] id: GO:0008277 name: regulation of G protein-coupled receptor signaling pathway namespace: biological_process def: "Any process that modulates the frequency, rate or extent of G protein-coupled receptor signaling pathway." [GOC:go_curators] synonym: "regulation of G protein coupled receptor protein signaling pathway" EXACT [] synonym: "regulation of G protein coupled receptor protein signalling pathway" EXACT [] synonym: "regulation of G-protein coupled receptor protein signaling pathway" EXACT [] synonym: "regulation of G-protein coupled receptor protein signalling pathway" EXACT [] synonym: "regulation of G-protein-coupled receptor protein signalling pathway" EXACT [] synonym: "regulation of GPCR protein signaling pathway" EXACT [] synonym: "regulation of GPCR protein signalling pathway" EXACT [] is_a: GO:0009966 ! regulation of signal transduction intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0007186 ! regulates G protein-coupled receptor signaling pathway relationship: RO:0002211 GO:0007186 ! regulates G protein-coupled receptor signaling pathway [Term] id: GO:0008283 name: cell population proliferation namespace: biological_process def: "The multiplication or reproduction of cells, resulting in the expansion of a cell population." [GOC:mah, GOC:mb] comment: This term was moved out from being a child of 'cellular process' because it is a cell population-level process, and cellular processes are restricted to those processes that involve individual cells. Also note that this term is intended to be used for the proliferation of cells within a multicellular organism, not for the expansion of a population of single-celled organisms. subset: goslim_agr subset: goslim_chembl subset: goslim_drosophila subset: goslim_flybase_ribbon subset: goslim_mouse subset: goslim_pir synonym: "cell proliferation" RELATED [] is_a: GO:0009987 ! cellular process property_value: RO:0002161 NCBITaxon:4751 [Term] id: GO:0008284 name: positive regulation of cell population proliferation namespace: biological_process def: "Any process that activates or increases the rate or extent of cell proliferation." [GOC:go_curators] synonym: "activation of cell proliferation" NARROW [] synonym: "positive regulation of cell proliferation" RELATED [] synonym: "stimulation of cell proliferation" NARROW [] synonym: "up regulation of cell proliferation" EXACT [] synonym: "up-regulation of cell proliferation" EXACT [] synonym: "upregulation of cell proliferation" EXACT [] is_a: GO:0042127 ! regulation of cell population proliferation is_a: GO:0048522 ! positive regulation of cellular process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0008283 ! positively regulates cell population proliferation relationship: RO:0002213 GO:0008283 ! positively regulates cell population proliferation property_value: RO:0002161 NCBITaxon:4751 [Term] id: GO:0008285 name: negative regulation of cell population proliferation namespace: biological_process def: "Any process that stops, prevents or reduces the rate or extent of cell proliferation." [GOC:go_curators] synonym: "down regulation of cell proliferation" EXACT [] synonym: "down-regulation of cell proliferation" EXACT [] synonym: "downregulation of cell proliferation" EXACT [] synonym: "inhibition of cell proliferation" NARROW [] synonym: "negative regulation of cell proliferation" RELATED [] is_a: GO:0042127 ! regulation of cell population proliferation is_a: GO:0048523 ! negative regulation of cellular process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0008283 ! negatively regulates cell population proliferation relationship: RO:0002212 GO:0008283 ! negatively regulates cell population proliferation property_value: RO:0002161 NCBITaxon:4751 [Term] id: GO:0008286 name: insulin receptor signaling pathway namespace: biological_process def: "The series of molecular signals generated as a consequence of the insulin receptor binding to insulin." [GOC:ceb] synonym: "daf-2 receptor signaling pathway" NARROW [] synonym: "insulin receptor signalling pathway" EXACT [] xref: Reactome:R-HSA-74752 "Signaling by Insulin receptor" is_a: GO:0007169 ! cell surface receptor protein tyrosine kinase signaling pathway relationship: BFO:0000050 GO:0032869 ! part of cellular response to insulin stimulus relationship: RO:0002162 NCBITaxon:6072 ! in taxon Eumetazoa [Term] id: GO:0008289 name: lipid binding namespace: molecular_function def: "Binding to a lipid." [GOC:ai] subset: goslim_agr subset: goslim_candida subset: goslim_chembl subset: goslim_drosophila subset: goslim_euk_cellular_processes_ribbon subset: goslim_flybase_ribbon subset: goslim_generic subset: goslim_mouse subset: goslim_pir subset: goslim_plant subset: goslim_plant_ribbon subset: goslim_prokaryote subset: goslim_prokaryote_ribbon subset: goslim_yeast is_a: BFO:0000003 is_a: GO:0005488 ! binding intersection_of: GO:0005488 ! binding intersection_of: RO:0004009 CHEBI:18059 ! has primary input relationship: RO:0004009 CHEBI:18059 ! has primary input [Term] id: GO:0008291 name: acetylcholine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving acetylcholine, the acetic acid ester of the organic base choline. Acetylcholine is a major neurotransmitter and neuromodulator both in the central and peripheral nervous systems. It also acts as a paracrine signal in various non-neural tissues." [GOC:jl, GOC:nln, ISBN:0192800752] synonym: "acetylcholine metabolism" EXACT [] is_a: BFO:0000003 is_a: GO:0008152 ! metabolic process intersection_of: GO:0008152 ! metabolic process intersection_of: RO:0004007 CHEBI:15355 ! has primary input or output relationship: RO:0004007 CHEBI:15355 ! has primary input or output [Term] id: GO:0008292 name: acetylcholine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of acetylcholine, the acetic acid ester of the organic base choline." [GOC:jl, ISBN:0192800752] synonym: "acetylcholine anabolism" EXACT [] synonym: "acetylcholine biosynthesis" EXACT [] synonym: "acetylcholine formation" EXACT [] synonym: "acetylcholine synthesis" EXACT [] is_a: GO:0008291 ! acetylcholine metabolic process is_a: GO:0009058 ! biosynthetic process intersection_of: GO:0009058 ! biosynthetic process intersection_of: RO:0004008 CHEBI:15355 ! has primary output relationship: RO:0004008 CHEBI:15355 ! has primary output [Term] id: GO:0008299 name: isoprenoid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of an isoprenoid compound, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues." [ISBN:0198506732] synonym: "isoprenoid anabolism" EXACT [] synonym: "isoprenoid biosynthesis" EXACT [] synonym: "isoprenoid formation" EXACT [] synonym: "isoprenoid synthesis" EXACT [] synonym: "polyisoprenoid anabolism" NARROW [] synonym: "polyisoprenoid biosynthesis" NARROW [] synonym: "polyisoprenoid biosynthetic process" NARROW [] synonym: "polyisoprenoid formation" NARROW [] synonym: "polyisoprenoid synthesis" NARROW [] synonym: "polyterpene biosynthesis" NARROW [] synonym: "polyterpene biosynthetic process" NARROW [] xref: MetaCyc:POLYISOPRENSYN-PWY is_a: GO:0006720 ! isoprenoid metabolic process is_a: GO:0008610 ! lipid biosynthetic process intersection_of: GO:0009058 ! biosynthetic process intersection_of: RO:0004008 CHEBI:24913 ! has primary output relationship: RO:0004008 CHEBI:24913 ! has primary output [Term] id: GO:0008300 name: isoprenoid catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of an isoprenoid compound, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues." [ISBN:0198506732] synonym: "isoprenoid breakdown" EXACT [] synonym: "isoprenoid catabolism" EXACT [] synonym: "isoprenoid degradation" EXACT [] synonym: "polyisoprenoid breakdown" NARROW [] synonym: "polyisoprenoid catabolic process" NARROW [] synonym: "polyisoprenoid catabolism" NARROW [] synonym: "polyisoprenoid degradation" NARROW [] synonym: "polyterpene catabolic process" NARROW [] synonym: "polyterpene catabolism" NARROW [] is_a: GO:0006720 ! isoprenoid metabolic process is_a: GO:0016042 ! lipid catabolic process intersection_of: GO:0009056 ! catabolic process intersection_of: RO:0004009 CHEBI:24913 ! has primary input relationship: RO:0004009 CHEBI:24913 ! has primary input property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/28908" xsd:anyURI [Term] id: GO:0008306 name: associative learning namespace: biological_process def: "Learning by associating a stimulus (the cause) with a particular outcome (the effect)." [ISBN:0582227089] synonym: "classical conditioning" EXACT [] synonym: "conditional learning" EXACT [] synonym: "conditional response" EXACT [] synonym: "Pavlovian conditioning" EXACT [] xref: Wikipedia:Learning#Associative_learning is_a: GO:0007612 ! learning [Term] id: GO:0008320 name: protein transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of a protein from one side of a membrane to the other." [GOC:jl] synonym: "protein channel activity" RELATED [] xref: Reactome:R-HSA-1268022 "TOMM40 complex translocates proteins from the cytosol to the mitochondrial intermembrane space" xref: Reactome:R-HSA-1299475 "TIMM23 PAM translocates proteins from the mitochondrial intermembrane space to the mitochondrial matrix" xref: Reactome:R-HSA-184269 "Monoubiquitinated N-myristoyl GAG polyprotein is targeted to the late endosomal vesicle membrane by the ESCRT-I complex" xref: Reactome:R-HSA-3149434 "Transport of GAG to the Plasma Membrane" xref: Reactome:R-HSA-5205661 "Pink1 is recruited from the cytoplasm to the mitochondria" xref: Reactome:R-HSA-5210943 "pagA(197-794):ANTRX2 oligomer transports cya and lef (target cell endosome to cytosol)" xref: Reactome:R-HSA-5210947 "pagA(197-794):ANTRX1 oligomer transports cya and lef (target cell endosome to cytosol)" xref: Reactome:R-HSA-5228406 "tetX HC transports tetX LC from target cell endosome membrane into cytosol" xref: Reactome:R-HSA-5229111 "AP4 transports APP from trans-Golgi network to endosome lumen" xref: Reactome:R-HSA-5244404 "botB HC transports botB LC from target cell synaptic vesicle membrane into cytosol" xref: Reactome:R-HSA-5244428 "botA HC transports botA LC from target cell synaptic vesicle membrane into cytosol" xref: Reactome:R-HSA-5244506 "botE HC transports botE LC from target cell synaptic vesicle membrane into cytosol" xref: Reactome:R-HSA-5246514 "botC HC transports botC LC from target cell synaptic vesicle membrane to cytosol" xref: Reactome:R-HSA-5250616 "botD HC transports botD LC from target cell synaptic vesicle membrane into cytosol" xref: Reactome:R-HSA-5250884 "botF HC transports botF LC from target cell synaptic vesicle membrane into cytosol" xref: Reactome:R-HSA-5250972 "botG HC transports botG LC from target cell synaptic vesicle membrane into cytosol" xref: Reactome:R-HSA-5336420 "DT fragment B transports DT fragment A from target cell endosome membrane" xref: Reactome:R-HSA-9636375 "SecA2 transports SapM from cytoplasm to cytosol" xref: Reactome:R-HSA-9698930 "HCMV C Nucleocapsid Translocation" xref: Reactome:R-HSA-9698933 "HCMV B Nucleocapsid Translocation" xref: Reactome:R-HSA-9760705 "GspD2:GspC2:GspS2 transports LT from periplasmic to extracellular space" is_a: GO:0022884 ! macromolecule transmembrane transporter activity is_a: GO:0140318 ! protein transporter activity intersection_of: GO:0005215 ! transporter activity intersection_of: RO:0002342 GO:0016020 ! results in transport across membrane intersection_of: RO:0004009 PR:000000001 ! has primary input protein relationship: BFO:0000050 GO:0071806 {source="GO_REF:0000090"} ! part of protein transmembrane transport [Term] id: GO:0008324 name: monoatomic cation transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of cation from one side of a membrane to the other." [GOC:dgf, GOC:mtg_transport, ISBN:0815340729] synonym: "cation transmembrane transporter activity" BROAD [] synonym: "transmembrane cation transporter activity" EXACT [] is_a: GO:0015075 ! monoatomic ion transmembrane transporter activity intersection_of: GO:0022857 ! transmembrane transporter activity intersection_of: RO:0004009 CHEBI:23906 ! has primary input relationship: BFO:0000050 GO:0098655 ! part of monoatomic cation transmembrane transport relationship: RO:0004009 CHEBI:23906 ! has primary input property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/24479" xsd:anyURI [Term] id: GO:0008328 name: ionotropic glutamate receptor complex namespace: cellular_component def: "A multimeric assembly of four or five subunits which form a structure with an extracellular N-terminus and a large loop that together form the ligand binding domain. The C-terminus is intracellular. The ionotropic glutamate receptor complex itself acts as a ligand-gated ion channel; on binding glutamate, charged ions pass through a channel in the center of the receptor complex." [PMID:20716669, PMID:34753794] is_a: GO:0034702 ! monoatomic ion channel complex is_a: GO:0098878 ! neurotransmitter receptor complex intersection_of: GO:0032991 ! protein-containing complex intersection_of: RO:0002215 GO:0004970 ! capable of glutamate-gated receptor activity relationship: RO:0002215 GO:0004970 ! capable of glutamate-gated receptor activity [Term] id: GO:0008347 name: glial cell migration namespace: biological_process def: "The orderly movement of a glial cell, non-neuronal cells that provide support and nutrition, maintain homeostasis, form myelin, and participate in signal transmission in the nervous system." [GOC:jl, GOC:mtg_sensu] synonym: "glia cell migration" EXACT [] is_a: BFO:0000003 is_a: GO:0016477 ! cell migration intersection_of: GO:0016477 ! cell migration intersection_of: RO:0002565 CL:0000125 ! results in movement of glial cell relationship: BFO:0000050 GO:0042063 ! part of gliogenesis relationship: RO:0002565 CL:0000125 ! results in movement of glial cell [Term] id: GO:0008348 name: negative regulation of antimicrobial humoral response namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of an antimicrobial humoral response." [GOC:go_curators] synonym: "attenuation of antimicrobial humoral response" EXACT [] synonym: "down regulation of antimicrobial humoral response" EXACT [] synonym: "down-regulation of antimicrobial humoral response" EXACT [] synonym: "downregulation of antimicrobial humoral response" EXACT [] synonym: "inhibition of antimicrobial humoral response" NARROW [] is_a: GO:0002759 ! regulation of antimicrobial humoral response is_a: GO:0002832 ! negative regulation of response to biotic stimulus is_a: GO:0002921 ! negative regulation of humoral immune response is_a: GO:0031348 ! negative regulation of defense response is_a: GO:0032102 ! negative regulation of response to external stimulus intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0019730 ! negatively regulates antimicrobial humoral response relationship: RO:0002212 GO:0019730 ! negatively regulates antimicrobial humoral response property_value: RO:0002161 NCBITaxon:4895 [Term] id: GO:0008354 name: germ cell migration namespace: biological_process def: "The orderly movement of a cell specialized to produce haploid gametes through the embryo from its site of production to the place where the gonads will form." [GOC:bf, GOC:jl] synonym: "germ-cell migration" EXACT [] synonym: "pole cell migration" NARROW [] synonym: "primordial germ cell migration" RELATED [] is_a: BFO:0000003 is_a: GO:0016477 ! cell migration intersection_of: GO:0016477 ! cell migration intersection_of: RO:0002565 CL:0000586 ! results in movement of germ cell relationship: BFO:0000050 GO:0007276 ! part of gamete generation relationship: RO:0002565 CL:0000586 ! results in movement of germ cell property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4751 [Term] id: GO:0008355 name: olfactory learning namespace: biological_process def: "Any process in an organism in which a relatively long-lasting adaptive behavioral change occurs in response to (repeated) exposure to an olfactory cue." [ISBN:0582227089] is_a: GO:0008306 ! associative learning is_a: GO:0042048 ! olfactory behavior [Term] id: GO:0008356 name: asymmetric cell division namespace: biological_process def: "The asymmetric division of cells to produce two daughter cells with different developmental potentials. It is of fundamental significance for the generation of cell diversity." [PMID:11672519] synonym: "asymmetric cytokinesis" RELATED [] synonym: "asymmetrical cell division" EXACT [] synonym: "asymmetrical cytokinesis" RELATED [] xref: Wikipedia:Asymmetric_cell_division is_a: GO:0051301 ! cell division [Term] id: GO:0008358 name: maternal determination of anterior/posterior axis, embryo namespace: biological_process def: "The specification of the anterior/posterior axis of the embryo by gradients of maternally-transcribed gene products; exemplified in insects by the morphogens, bicoid and nanos." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238] is_a: GO:0008595 ! anterior/posterior axis specification, embryo property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0008361 name: regulation of cell size namespace: biological_process def: "Any process that modulates the size of a cell." [GOC:go_curators] synonym: "cell size control" EXACT [] is_a: GO:0032535 ! regulation of cellular component size [Term] id: GO:0008366 name: axon ensheathment namespace: biological_process def: "Any process in which the axon of a neuron is insulated, and that insulation maintained, thereby preventing dispersion of the electrical signal." [GOC:jl, ISBN:0878932437] synonym: "cellular axon ensheathment" EXACT [] synonym: "cellular nerve ensheathment" RELATED [] synonym: "nerve ensheathment" RELATED [] is_a: GO:0007272 ! ensheathment of neurons relationship: has_participant GO:0030424 ! axon [Term] id: GO:0008406 name: gonad development namespace: biological_process def: "The process whose specific outcome is the progression of the gonad over time, from its formation to the mature structure. The gonad is an animal organ that produces gametes; in some species it also produces hormones." [GOC:ems, ISBN:0198506732] synonym: "gonadogenesis" EXACT [GOC:cjm] is_a: GO:0048513 ! animal organ development is_a: GO:0048608 ! reproductive structure development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0000991 ! results in development of gonad relationship: BFO:0000050 GO:0045137 ! part of development of primary sexual characteristics relationship: RO:0002296 UBERON:0000991 ! results in development of gonad property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0008502 name: melatonin receptor activity namespace: molecular_function def: "Combining with melatonin, N-acetyl-5-methoxytryptamine, to initiate a change in cell activity. Melatonin is a neuroendocrine substance that stimulates the aggregation of melanosomes in melanophores, thus lightening the skin." [GOC:ai, ISBN:0198506732] is_a: GO:0004930 ! G protein-coupled receptor activity intersection_of: GO:0038023 ! signaling receptor activity intersection_of: RO:0004009 CHEBI:16796 ! has primary input relationship: RO:0004009 CHEBI:16796 ! has primary input [Term] id: GO:0008504 name: monoamine transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of monoamines, organic compounds that contain one amino group that is connected to an aromatic ring by an ethylene group (-CH2-CH2-), from one side of a membrane to the other." [GOC:mah] xref: Reactome:R-HSA-372542 "Loading of dopamine into synaptic veiscles" xref: Reactome:R-HSA-379393 "SLC6A3 cotransports DA, Na+, Cl- from extracellular region to cytosol" xref: Reactome:R-HSA-380586 "loading of Serotonin in synaptic vesicles" xref: Reactome:R-HSA-380620 "Reuptake of serotonin from the synapse" xref: Reactome:R-HSA-5660706 "Defective SLC6A3 does not cotransport DA, Na+ from extracellular region to cytosol" is_a: GO:0022804 ! active transmembrane transporter activity intersection_of: GO:0022857 ! transmembrane transporter activity intersection_of: RO:0004009 CHEBI:63534 ! has primary input relationship: BFO:0000050 GO:0015844 ! part of monoamine transport relationship: RO:0004009 CHEBI:63534 ! has primary input [Term] id: GO:0008519 name: ammonium channel activity namespace: molecular_function def: "Enables the energy-independent facilitated diffusion of ammonium through a transmembrane aqueous pore or channel." [PMID:17710640] synonym: "ammonia transmembrane transporter activity" BROAD [] synonym: "ammonium transmembrane transporter activity" BROAD [] xref: MetaCyc:RXN-9615 xref: Reactome:R-HSA-444393 "RhCG mediates ammonium influx into kidney collecting duct cells" xref: Reactome:R-HSA-444416 "RHAG transports NH4+ from cytosol to extracellular region (red blood cells)" xref: Reactome:R-HSA-444419 "RhBG mediates ammonium effflux out of kidney collecting duct cells" xref: Reactome:R-HSA-446277 "RhCG mediates ammonium efflux out of kidney collecting duct cells" xref: Reactome:R-HSA-446278 "RhBG mediates ammonium influx into kidney collecting duct cells" xref: Reactome:R-HSA-5623051 "Defective RHAG does not transport NH4+ from cytosol to extracellular region (rbc)" xref: TC:1.A.11 is_a: GO:0015267 ! channel activity intersection_of: GO:0015267 ! channel activity intersection_of: GO:0022857 ! transmembrane transporter activity intersection_of: RO:0004009 CHEBI:28938 ! has primary input relationship: BFO:0000050 GO:0072488 {source="GO_REF:0000090"} ! part of ammonium transmembrane transport relationship: RO:0004009 CHEBI:28938 ! has primary input property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/22368" xsd:anyURI property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/23129" xsd:anyURI property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/26941" xsd:anyURI property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/27521" xsd:anyURI [Term] id: GO:0008528 name: G protein-coupled peptide receptor activity namespace: molecular_function def: "Combining with a peptide and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:dph, GOC:tb] synonym: "G protein coupled peptide receptor activity" EXACT [] synonym: "G-protein coupled peptide receptor activity" EXACT [] synonym: "peptide receptor activity, G protein coupled" EXACT [] synonym: "peptide receptor activity, G-protein coupled" EXACT [GOC:bf] is_a: GO:0001653 ! peptide receptor activity is_a: GO:0004930 ! G protein-coupled receptor activity [Term] id: GO:0008544 name: epidermis development namespace: biological_process def: "The process whose specific outcome is the progression of the epidermis over time, from its formation to the mature structure. The epidermis is the outer epithelial layer of an animal, it may be a single layer that produces an extracellular material (e.g. the cuticle of arthropods) or a complex stratified squamous epithelium, as in the case of many vertebrate species." [GOC:go_curators, UBERON:0001003] synonym: "hypodermis development" RELATED [GOC:kmv, GOC:rk] is_a: GO:0009888 ! tissue development property_value: RO:0002161 NCBITaxon:147554 property_value: RO:0002161 NCBITaxon:33090 property_value: RO:0002161 NCBITaxon:33630 property_value: RO:0002161 NCBITaxon:33682 property_value: RO:0002161 NCBITaxon:38254 property_value: RO:0002161 NCBITaxon:4891 [Term] id: GO:0008584 name: male gonad development namespace: biological_process def: "The process whose specific outcome is the progression of the male gonad over time, from its formation to the mature structure." [GOC:jid] synonym: "testicular development" EXACT [GOC:sl] synonym: "testis development" EXACT [GOC:sl] xref: Reactome:R-HSA-9690406 "Transcriptional regulation of testis differentiation" is_a: GO:0008406 ! gonad development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0000473 ! results in development of testis relationship: BFO:0000050 GO:0046546 ! part of development of primary male sexual characteristics relationship: RO:0002296 UBERON:0000473 ! results in development of testis property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0008585 name: female gonad development namespace: biological_process def: "The process whose specific outcome is the progression of the female gonad over time, from its formation to the mature structure." [GOC:dph, GOC:jid, GOC:tb] synonym: "ovarian development" RELATED [GOC:sl] synonym: "ovary development" RELATED [GOC:sl] is_a: GO:0008406 ! gonad development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0000992 ! results in development of ovary relationship: BFO:0000050 GO:0046545 ! part of development of primary female sexual characteristics relationship: RO:0002296 UBERON:0000992 ! results in development of ovary [Term] id: GO:0008594 name: photoreceptor cell morphogenesis namespace: biological_process def: "The process in which the structures of a photoreceptor cell are generated and organized. This process occurs while the initially relatively unspecialized cell is acquiring the specialized features of a photoreceptor cell, a sensory cell that reacts to the presence of light. An example of this is found in Drosophila melanogaster." [GOC:jid, GOC:mah] synonym: "photoreceptor development" RELATED [] is_a: GO:0048667 ! cell morphogenesis involved in neuron differentiation intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 CL:0000210 ! results in morphogenesis of photoreceptor cell relationship: BFO:0000050 GO:0042461 ! part of photoreceptor cell development relationship: RO:0002298 CL:0000210 ! results in morphogenesis of photoreceptor cell [Term] id: GO:0008595 name: anterior/posterior axis specification, embryo namespace: biological_process def: "The specification of the anterior/posterior axis of the embryo by the products of genes expressed maternally and genes expressed in the zygote." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238] synonym: "anterior/posterior axis determination, embryo" RELATED [GOC:dph] is_a: GO:0000578 ! embryonic axis specification is_a: GO:0009948 ! anterior/posterior axis specification relationship: BFO:0000050 GO:0007351 ! part of tripartite regional subdivision property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0008610 name: lipid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent." [GOC:go_curators] synonym: "lipid anabolism" EXACT [] synonym: "lipid biosynthesis" EXACT [] synonym: "lipid formation" EXACT [] synonym: "lipid synthesis" EXACT [] synonym: "lipogenesis" EXACT [GOC:sl] is_a: GO:0006629 ! lipid metabolic process is_a: GO:0009058 ! biosynthetic process intersection_of: GO:0009058 ! biosynthetic process intersection_of: RO:0004008 CHEBI:18059 ! has primary output relationship: RO:0004008 CHEBI:18059 ! has primary output [Term] id: GO:0008643 name: carbohydrate transport namespace: biological_process def: "The directed movement of carbohydrate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Carbohydrates are a group of organic compounds based of the general formula Cx(H2O)y." [GOC:ai] subset: goslim_pir subset: goslim_yeast synonym: "sugar transport" NARROW [] is_a: BFO:0000003 is_a: GO:0006810 ! transport intersection_of: GO:0006810 ! transport intersection_of: RO:0004009 CHEBI:16646 ! has primary input relationship: RO:0004009 CHEBI:16646 ! has primary input [Term] id: GO:0008645 name: hexose transmembrane transport namespace: biological_process def: "The process in which hexose is transported across a membrane. Hexoses are aldoses with a chain of six carbon atoms in the molecule." [GOC:vw] comment: Note that this term is not intended for use in annotating lateral movement within membranes. synonym: "hexose membrane transport" RELATED [] synonym: "hexose transport" RELATED [] synonym: "high-affinity hexose transport" NARROW [] synonym: "low-affinity hexose transport" NARROW [] xref: Reactome:R-HSA-189200 "Cellular hexose transport" is_a: GO:0015749 ! monosaccharide transmembrane transport intersection_of: GO:0055085 ! transmembrane transport intersection_of: RO:0004009 CHEBI:18133 ! has primary input relationship: RO:0004009 CHEBI:18133 ! has primary input creation_date: 2010-04-08T10:27:23Z [Term] id: GO:0008652 name: amino acid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of amino acids, organic acids containing one or more amino substituents." [ISBN:0198506732] synonym: "amino acid anabolism" EXACT [] synonym: "amino acid biosynthesis" EXACT [] synonym: "amino acid formation" EXACT [] synonym: "amino acid synthesis" EXACT [] synonym: "cellular amino acid biosynthetic process" EXACT [] xref: Wikipedia:Amino_acid_synthesis is_a: GO:0006520 ! amino acid metabolic process is_a: GO:0009058 ! biosynthetic process intersection_of: GO:0009058 ! biosynthetic process intersection_of: RO:0004008 CHEBI:35238 ! has primary output relationship: RO:0004008 CHEBI:35238 ! has primary output property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/17904" xsd:anyURI property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/27304" xsd:anyURI [Term] id: GO:0009056 name: catabolic process namespace: biological_process def: "A cellular process consisting of the biochemical pathways by which a living organism breaks down substances. This includes the breakdown of carbon compounds with the liberation of energy for use by the cell or organism." [ISBN:0198547684] subset: gocheck_do_not_annotate subset: goslim_agr subset: goslim_chembl subset: goslim_plant subset: goslim_plant_ribbon synonym: "breakdown of chemical" EXACT [] synonym: "breakdown of molecule" EXACT [] synonym: "breakdown of substance" EXACT [] synonym: "catabolism" EXACT [] synonym: "cellular breakdown" EXACT [] synonym: "cellular catabolism" EXACT [] synonym: "cellular degradation" EXACT [] synonym: "degradation" EXACT [] xref: Wikipedia:Catabolism is_a: GO:0008152 ! metabolic process property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/28921" xsd:anyURI property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/28932" xsd:anyURI property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/29627" xsd:anyURI creation_date: 2012-10-17T15:52:35Z [Term] id: GO:0009057 name: macromolecule catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:mah] subset: gocheck_do_not_annotate subset: goslim_pir synonym: "biopolymer catabolic process" EXACT [GOC:mtg_chebi_dec09] synonym: "cellular macromolecule catabolic process" RELATED [] synonym: "cellular macromolecule catabolism" RELATED [] synonym: "cellular macromolecule degradation" RELATED [] synonym: "macromolecule breakdown" EXACT [] synonym: "macromolecule catabolism" EXACT [] synonym: "macromolecule degradation" EXACT [] synonym: "multicellular organismal macromolecule catabolic process" NARROW [] is_a: GO:0009056 ! catabolic process is_a: GO:0043170 ! macromolecule metabolic process intersection_of: GO:0009056 ! catabolic process intersection_of: RO:0004009 CHEBI:33694 ! has primary input relationship: RO:0004009 CHEBI:33694 ! has primary input [Term] id: GO:0009058 name: biosynthetic process namespace: biological_process def: "A cellular process consisting of the biochemical pathways by which a living organism synthesizes chemical substances. This typically represents the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones." [GOC:curators, ISBN:0198547684] subset: gocheck_do_not_annotate subset: goslim_chembl subset: goslim_metagenomics subset: goslim_plant subset: goslim_plant_ribbon synonym: "anabolism" EXACT [] synonym: "biosynthesis" EXACT [] synonym: "formation" BROAD [] synonym: "multicellular organismal biosynthetic process" NARROW [] synonym: "single-organism biosynthetic process" RELATED [] synonym: "synthesis" EXACT [] xref: Wikipedia:Anabolism is_a: GO:0008152 ! metabolic process property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/28932" xsd:anyURI creation_date: 2012-10-17T15:52:18Z [Term] id: GO:0009059 name: macromolecule biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:mah] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_annotate subset: goslim_pir synonym: "biopolymer biosynthetic process" EXACT [GOC:mtg_chebi_dec09] synonym: "macromolecule anabolism" EXACT [] synonym: "macromolecule biosynthesis" EXACT [] synonym: "macromolecule formation" EXACT [] synonym: "macromolecule synthesis" EXACT [] is_a: GO:0009058 ! biosynthetic process is_a: GO:0043170 ! macromolecule metabolic process intersection_of: GO:0009058 ! biosynthetic process intersection_of: RO:0004008 CHEBI:33694 ! has primary output relationship: RO:0004008 CHEBI:33694 ! has primary output property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/15249" xsd:anyURI property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/25418" xsd:anyURI property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/27189" xsd:anyURI [Term] id: GO:0009062 name: fatty acid catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes." [GOC:go_curators] synonym: "fatty acid breakdown" EXACT [] synonym: "fatty acid catabolism" EXACT [] synonym: "fatty acid degradation" EXACT [] xref: Reactome:R-HSA-390918 "Peroxisomal lipid metabolism" xref: Wikipedia:Fatty_acid_degradation is_a: GO:0006631 ! fatty acid metabolic process is_a: GO:0016042 ! lipid catabolic process is_a: GO:0072329 ! monocarboxylic acid catabolic process intersection_of: GO:0009056 ! catabolic process intersection_of: RO:0004009 CHEBI:28868 ! has primary input relationship: RO:0004009 CHEBI:28868 ! has primary input property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/28908" xsd:anyURI [Term] id: GO:0009063 name: amino acid catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of amino acids, organic acids containing one or more amino substituents." [GOC:ai] synonym: "amino acid breakdown" EXACT [] synonym: "amino acid catabolism" EXACT [] synonym: "amino acid degradation" EXACT [] synonym: "cellular amino acid catabolic process" EXACT [] is_a: GO:0006520 ! amino acid metabolic process is_a: GO:0009056 ! catabolic process intersection_of: GO:0009056 ! catabolic process intersection_of: RO:0004009 CHEBI:35238 ! has primary input relationship: RO:0004009 CHEBI:35238 ! has primary input property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/17904" xsd:anyURI [Term] id: GO:0009064 name: glutamine family amino acid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving amino acids of the glutamine family, comprising arginine, glutamate, glutamine and proline." [GOC:ai] synonym: "glutamine family amino acid metabolism" EXACT [] xref: Reactome:R-HSA-8964539 "Glutamate and glutamine metabolism" is_a: GO:0170033 ! L-amino acid metabolic process is_a: GO:0170039 ! proteinogenic amino acid metabolic process intersection_of: GO:0008152 ! metabolic process intersection_of: RO:0004007 CHEBI:24318 ! has primary input or output relationship: RO:0004007 CHEBI:24318 ! has primary input or output [Term] id: GO:0009070 name: serine family amino acid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of amino acids of the serine family, comprising cysteine, glycine, homoserine, selenocysteine and serine." [GOC:ai] synonym: "serine family amino acid anabolism" EXACT [] synonym: "serine family amino acid biosynthesis" EXACT [] synonym: "serine family amino acid formation" EXACT [] synonym: "serine family amino acid synthesis" EXACT [] is_a: GO:1901607 ! alpha-amino acid biosynthetic process intersection_of: GO:0009058 ! biosynthetic process intersection_of: RO:0004008 CHEBI:26650 ! has primary output relationship: RO:0004008 CHEBI:26650 ! has primary output [Term] id: GO:0009072 name: aromatic amino acid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving aromatic amino acid family, amino acids with aromatic ring (phenylalanine, tyrosine, tryptophan)." [GOC:go_curators] synonym: "aromatic amino acid family metabolic process" EXACT [] synonym: "aromatic amino acid family metabolism" EXACT [] xref: Reactome:R-HSA-8963691 "Phenylalanine and tyrosine metabolism" is_a: GO:0006520 ! amino acid metabolic process is_a: GO:0019752 ! carboxylic acid metabolic process intersection_of: GO:0008152 ! metabolic process intersection_of: RO:0004007 CHEBI:33856 ! has primary input or output relationship: RO:0004007 CHEBI:33856 ! has primary input or output [Term] id: GO:0009073 name: aromatic amino acid family biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of aromatic amino acid family, amino acids with aromatic ring (phenylalanine, tyrosine, tryptophan)." [GOC:go_curators] synonym: "aromatic amino acid family anabolism" EXACT [] synonym: "aromatic amino acid family biosynthesis" EXACT [] synonym: "aromatic amino acid family biosynthetic process, shikimate pathway" RELATED [] synonym: "aromatic amino acid family formation" EXACT [] synonym: "aromatic amino acid family synthesis" EXACT [] xref: MetaCyc:COMPLETE-ARO-PWY is_a: GO:0009072 ! aromatic amino acid metabolic process is_a: GO:0046394 ! carboxylic acid biosynthetic process intersection_of: GO:0009058 ! biosynthetic process intersection_of: RO:0004008 CHEBI:33856 ! has primary output relationship: RO:0004008 CHEBI:33856 ! has primary output [Term] id: GO:0009074 name: aromatic amino acid family catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of aromatic amino acid family, amino acids with aromatic ring (phenylalanine, tyrosine, tryptophan)." [GOC:go_curators] synonym: "aromatic amino acid family breakdown" EXACT [] synonym: "aromatic amino acid family catabolism" EXACT [] synonym: "aromatic amino acid family degradation" EXACT [] is_a: GO:0009072 ! aromatic amino acid metabolic process is_a: GO:0046395 ! carboxylic acid catabolic process intersection_of: GO:0009056 ! catabolic process intersection_of: RO:0004009 CHEBI:33856 ! has primary input relationship: RO:0004009 CHEBI:33856 ! has primary input [Term] id: GO:0009084 name: glutamine family amino acid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of amino acids of the glutamine family, comprising arginine, glutamate, glutamine and proline." [GOC:ai] synonym: "glutamine family amino acid anabolism" EXACT [] synonym: "glutamine family amino acid biosynthesis" EXACT [] synonym: "glutamine family amino acid formation" EXACT [] synonym: "glutamine family amino acid synthesis" EXACT [] is_a: GO:0009064 ! glutamine family amino acid metabolic process is_a: GO:0170034 ! L-amino acid biosynthetic process is_a: GO:0170038 ! proteinogenic amino acid biosynthetic process intersection_of: GO:0009058 ! biosynthetic process intersection_of: RO:0004008 CHEBI:24318 ! has primary output relationship: RO:0004008 CHEBI:24318 ! has primary output [Term] id: GO:0009100 name: glycoprotein metabolic process namespace: biological_process def: "The chemical reactions and pathways involving glycoproteins, a protein that contains covalently bound glycose (i.e. monosaccharide) residues; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide." [GOC:go_curators, ISBN:0198506732] subset: goslim_drosophila synonym: "glycoprotein metabolism" EXACT [] is_a: GO:0019538 ! protein metabolic process is_a: GO:1901135 ! carbohydrate derivative metabolic process intersection_of: GO:0008152 ! metabolic process intersection_of: RO:0004007 CHEBI:17089 ! has primary input or output relationship: RO:0004007 CHEBI:17089 ! has primary input or output [Term] id: GO:0009101 name: glycoprotein biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of glycoproteins, a protein that contains covalently bound glycose (i.e. monosaccharide) residues; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide." [PMID:35536965] subset: goslim_generic subset: goslim_pombe subset: goslim_prokaryote subset: goslim_yeast synonym: "glycoprotein anabolism" EXACT [] synonym: "glycoprotein biosynthesis" EXACT [] synonym: "glycoprotein formation" EXACT [] synonym: "glycoprotein synthesis" EXACT [] is_a: GO:0009059 ! macromolecule biosynthetic process is_a: GO:0009100 ! glycoprotein metabolic process is_a: GO:1901137 ! carbohydrate derivative biosynthetic process intersection_of: GO:0009058 ! biosynthetic process intersection_of: RO:0004008 CHEBI:17089 ! has primary output relationship: RO:0004008 CHEBI:17089 ! has primary output [Term] id: GO:0009117 name: nucleotide metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a nucleotide, a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the glycose moiety; may be mono-, di- or triphosphate; this definition includes cyclic nucleotides (nucleoside cyclic phosphates)." [GOC:ma] subset: goslim_pir synonym: "nucleotide metabolism" EXACT [] is_a: GO:0006753 ! nucleoside phosphate metabolic process intersection_of: GO:0008152 ! metabolic process intersection_of: RO:0004007 CHEBI:36976 ! has primary input or output relationship: RO:0004007 CHEBI:36976 ! has primary input or output [Term] id: GO:0009132 name: nucleoside diphosphate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a nucleoside diphosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with diphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] synonym: "nucleoside diphosphate metabolism" EXACT [] is_a: GO:0006753 ! nucleoside phosphate metabolic process intersection_of: GO:0008152 ! metabolic process intersection_of: RO:0004007 CHEBI:57930 ! has primary input or output relationship: RO:0004007 CHEBI:57930 ! has primary input or output [Term] id: GO:0009133 name: nucleoside diphosphate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a nucleoside diphosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with diphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] synonym: "nucleoside diphosphate anabolism" EXACT [] synonym: "nucleoside diphosphate biosynthesis" EXACT [] synonym: "nucleoside diphosphate formation" EXACT [] synonym: "nucleoside diphosphate synthesis" EXACT [] is_a: GO:0009132 ! nucleoside diphosphate metabolic process is_a: GO:1901293 ! nucleoside phosphate biosynthetic process intersection_of: GO:0009058 ! biosynthetic process intersection_of: RO:0004008 CHEBI:57930 ! has primary output relationship: RO:0004008 CHEBI:57930 ! has primary output [Term] id: GO:0009134 name: nucleoside diphosphate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of a nucleoside diphosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with diphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] synonym: "nucleoside diphosphate breakdown" EXACT [] synonym: "nucleoside diphosphate catabolism" EXACT [] synonym: "nucleoside diphosphate degradation" EXACT [] is_a: GO:0009132 ! nucleoside diphosphate metabolic process is_a: GO:1901292 ! nucleoside phosphate catabolic process intersection_of: GO:0009056 ! catabolic process intersection_of: RO:0004009 CHEBI:57930 ! has primary input relationship: RO:0004009 CHEBI:57930 ! has primary input [Term] id: GO:0009135 name: purine nucleoside diphosphate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving purine nucleoside diphosphate, a compound consisting of a purine base linked to a ribose or deoxyribose sugar esterified with diphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] synonym: "purine nucleoside diphosphate metabolism" EXACT [] is_a: GO:0009132 ! nucleoside diphosphate metabolic process intersection_of: GO:0008152 ! metabolic process intersection_of: RO:0004007 CHEBI:26391 ! has primary input or output relationship: RO:0004007 CHEBI:26391 ! has primary input or output [Term] id: GO:0009136 name: purine nucleoside diphosphate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of purine nucleoside diphosphate, a compound consisting of a purine base linked to a ribose or deoxyribose sugar esterified with diphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] synonym: "purine nucleoside diphosphate anabolism" EXACT [] synonym: "purine nucleoside diphosphate biosynthesis" EXACT [] synonym: "purine nucleoside diphosphate formation" EXACT [] synonym: "purine nucleoside diphosphate synthesis" EXACT [] is_a: GO:0009133 ! nucleoside diphosphate biosynthetic process is_a: GO:0009135 ! purine nucleoside diphosphate metabolic process intersection_of: GO:0009058 ! biosynthetic process intersection_of: RO:0004008 CHEBI:26391 ! has primary output relationship: RO:0004008 CHEBI:26391 ! has primary output [Term] id: GO:0009137 name: purine nucleoside diphosphate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of purine nucleoside diphosphate, a compound consisting of a purine base linked to a ribose or deoxyribose sugar esterified with diphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] synonym: "purine nucleoside diphosphate breakdown" EXACT [] synonym: "purine nucleoside diphosphate catabolism" EXACT [] synonym: "purine nucleoside diphosphate degradation" EXACT [] is_a: GO:0009134 ! nucleoside diphosphate catabolic process is_a: GO:0009135 ! purine nucleoside diphosphate metabolic process intersection_of: GO:0009056 ! catabolic process intersection_of: RO:0004009 CHEBI:26391 ! has primary input relationship: RO:0004009 CHEBI:26391 ! has primary input [Term] id: GO:0009141 name: nucleoside triphosphate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a nucleoside triphosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] synonym: "nucleoside triphosphate metabolism" EXACT [] is_a: GO:0006753 ! nucleoside phosphate metabolic process intersection_of: GO:0008152 ! metabolic process intersection_of: RO:0004007 CHEBI:61557 ! has primary input or output relationship: RO:0004007 CHEBI:61557 ! has primary input or output [Term] id: GO:0009142 name: nucleoside triphosphate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a nucleoside triphosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] synonym: "nucleoside triphosphate anabolism" EXACT [] synonym: "nucleoside triphosphate biosynthesis" EXACT [] synonym: "nucleoside triphosphate formation" EXACT [] synonym: "nucleoside triphosphate synthesis" EXACT [] is_a: GO:0009141 ! nucleoside triphosphate metabolic process is_a: GO:1901293 ! nucleoside phosphate biosynthetic process intersection_of: GO:0009058 ! biosynthetic process intersection_of: RO:0004008 CHEBI:61557 ! has primary output relationship: RO:0004008 CHEBI:61557 ! has primary output [Term] id: GO:0009143 name: nucleoside triphosphate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of a nucleoside triphosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] synonym: "nucleoside triphosphate breakdown" EXACT [] synonym: "nucleoside triphosphate catabolism" EXACT [] synonym: "nucleoside triphosphate degradation" EXACT [] is_a: GO:0009141 ! nucleoside triphosphate metabolic process is_a: GO:1901292 ! nucleoside phosphate catabolic process intersection_of: GO:0009056 ! catabolic process intersection_of: RO:0004009 CHEBI:61557 ! has primary input relationship: RO:0004009 CHEBI:61557 ! has primary input [Term] id: GO:0009144 name: purine nucleoside triphosphate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving purine nucleoside triphosphate, a compound consisting of a purine base linked to a ribose or deoxyribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] synonym: "purine nucleoside triphosphate metabolism" EXACT [] is_a: GO:0009141 ! nucleoside triphosphate metabolic process intersection_of: GO:0008152 ! metabolic process intersection_of: RO:0004007 CHEBI:26393 ! has primary input or output relationship: RO:0004007 CHEBI:26393 ! has primary input or output [Term] id: GO:0009145 name: purine nucleoside triphosphate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of purine nucleoside triphosphate, a compound consisting of a purine base linked to a ribose or deoxyribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] synonym: "purine nucleoside triphosphate anabolism" EXACT [] synonym: "purine nucleoside triphosphate biosynthesis" EXACT [] synonym: "purine nucleoside triphosphate formation" EXACT [] synonym: "purine nucleoside triphosphate synthesis" EXACT [] is_a: GO:0009142 ! nucleoside triphosphate biosynthetic process is_a: GO:0009144 ! purine nucleoside triphosphate metabolic process intersection_of: GO:0009058 ! biosynthetic process intersection_of: RO:0004008 CHEBI:26393 ! has primary output relationship: RO:0004008 CHEBI:26393 ! has primary output [Term] id: GO:0009146 name: purine nucleoside triphosphate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of purine nucleoside triphosphate, a compound consisting of a purine base linked to a ribose or deoxyribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] synonym: "purine nucleoside triphosphate breakdown" EXACT [] synonym: "purine nucleoside triphosphate catabolism" EXACT [] synonym: "purine nucleoside triphosphate degradation" EXACT [] is_a: GO:0009143 ! nucleoside triphosphate catabolic process is_a: GO:0009144 ! purine nucleoside triphosphate metabolic process intersection_of: GO:0009056 ! catabolic process intersection_of: RO:0004009 CHEBI:26393 ! has primary input relationship: RO:0004009 CHEBI:26393 ! has primary input [Term] id: GO:0009150 name: purine ribonucleotide metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a purine ribonucleotide, a compound consisting of ribonucleoside (a purine base linked to a ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732] synonym: "purine ribonucleotide metabolism" EXACT [] is_a: GO:0006163 ! purine nucleotide metabolic process is_a: GO:0009259 ! ribonucleotide metabolic process intersection_of: GO:0008152 ! metabolic process intersection_of: RO:0004007 CHEBI:26400 ! has primary input or output relationship: RO:0004007 CHEBI:26400 ! has primary input or output [Term] id: GO:0009152 name: purine ribonucleotide biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a purine ribonucleotide, a compound consisting of ribonucleoside (a purine base linked to a ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732] synonym: "purine ribonucleotide anabolism" EXACT [] synonym: "purine ribonucleotide biosynthesis" EXACT [] synonym: "purine ribonucleotide formation" EXACT [] synonym: "purine ribonucleotide synthesis" EXACT [] is_a: GO:0006164 ! purine nucleotide biosynthetic process is_a: GO:0009150 ! purine ribonucleotide metabolic process is_a: GO:0009260 ! ribonucleotide biosynthetic process intersection_of: GO:0009058 ! biosynthetic process intersection_of: RO:0004008 CHEBI:26400 ! has primary output relationship: RO:0004008 CHEBI:26400 ! has primary output [Term] id: GO:0009154 name: purine ribonucleotide catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of a purine ribonucleotide, a compound consisting of ribonucleoside (a purine base linked to a ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732] synonym: "purine ribonucleotide breakdown" EXACT [] synonym: "purine ribonucleotide catabolism" EXACT [] synonym: "purine ribonucleotide degradation" EXACT [] is_a: GO:0006195 ! purine nucleotide catabolic process is_a: GO:0009150 ! purine ribonucleotide metabolic process is_a: GO:0009261 ! ribonucleotide catabolic process intersection_of: GO:0009056 ! catabolic process intersection_of: RO:0004009 CHEBI:26400 ! has primary input relationship: RO:0004009 CHEBI:26400 ! has primary input [Term] id: GO:0009165 name: nucleotide biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of nucleotides, any nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the glycose moiety; may be mono-, di- or triphosphate; this definition includes cyclic-nucleotides (nucleoside cyclic phosphates)." [GOC:go_curators] synonym: "nucleotide anabolism" EXACT [] synonym: "nucleotide biosynthesis" EXACT [] synonym: "nucleotide formation" EXACT [] synonym: "nucleotide synthesis" EXACT [] is_a: GO:0009117 ! nucleotide metabolic process is_a: GO:1901293 ! nucleoside phosphate biosynthetic process intersection_of: GO:0009058 ! biosynthetic process intersection_of: RO:0004008 CHEBI:36976 ! has primary output relationship: RO:0004008 CHEBI:36976 ! has primary output [Term] id: GO:0009166 name: nucleotide catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of nucleotides, any nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the glycose moiety; may be mono-, di- or triphosphate; this definition includes cyclic-nucleotides (nucleoside cyclic phosphates)." [GOC:go_curators] synonym: "nucleotide breakdown" EXACT [] synonym: "nucleotide catabolism" EXACT [] synonym: "nucleotide degradation" EXACT [] is_a: GO:0009117 ! nucleotide metabolic process is_a: GO:1901292 ! nucleoside phosphate catabolic process intersection_of: GO:0009056 ! catabolic process intersection_of: RO:0004009 CHEBI:36976 ! has primary input relationship: RO:0004009 CHEBI:36976 ! has primary input [Term] id: GO:0009179 name: purine ribonucleoside diphosphate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving purine ribonucleoside diphosphate, a compound consisting of a purine base linked to a ribose sugar esterified with diphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] synonym: "purine ribonucleoside diphosphate metabolism" EXACT [] is_a: GO:0009135 ! purine nucleoside diphosphate metabolic process is_a: GO:0009185 ! ribonucleoside diphosphate metabolic process intersection_of: GO:0008152 ! metabolic process intersection_of: RO:0004007 CHEBI:26396 ! has primary input or output relationship: RO:0004007 CHEBI:26396 ! has primary input or output [Term] id: GO:0009180 name: purine ribonucleoside diphosphate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of purine ribonucleoside diphosphate, a compound consisting of a purine base linked to a ribose sugar esterified with diphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] synonym: "purine ribonucleoside diphosphate anabolism" EXACT [] synonym: "purine ribonucleoside diphosphate biosynthesis" EXACT [] synonym: "purine ribonucleoside diphosphate formation" EXACT [] synonym: "purine ribonucleoside diphosphate synthesis" EXACT [] is_a: GO:0009136 ! purine nucleoside diphosphate biosynthetic process is_a: GO:0009179 ! purine ribonucleoside diphosphate metabolic process is_a: GO:0009188 ! ribonucleoside diphosphate biosynthetic process intersection_of: GO:0009058 ! biosynthetic process intersection_of: RO:0004008 CHEBI:26396 ! has primary output relationship: RO:0004008 CHEBI:26396 ! has primary output [Term] id: GO:0009181 name: purine ribonucleoside diphosphate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of purine ribonucleoside diphosphate, a compound consisting of a purine base linked to a ribose sugar esterified with diphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] synonym: "purine ribonucleoside diphosphate breakdown" EXACT [] synonym: "purine ribonucleoside diphosphate catabolism" EXACT [] synonym: "purine ribonucleoside diphosphate degradation" EXACT [] is_a: GO:0009137 ! purine nucleoside diphosphate catabolic process is_a: GO:0009179 ! purine ribonucleoside diphosphate metabolic process is_a: GO:0009191 ! ribonucleoside diphosphate catabolic process intersection_of: GO:0009056 ! catabolic process intersection_of: RO:0004009 CHEBI:26396 ! has primary input relationship: RO:0004009 CHEBI:26396 ! has primary input [Term] id: GO:0009185 name: ribonucleoside diphosphate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a ribonucleoside diphosphate, a compound consisting of a nucleobase linked to a ribose sugar esterified with diphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] synonym: "ribonucleoside diphosphate metabolism" EXACT [] is_a: GO:0009132 ! nucleoside diphosphate metabolic process intersection_of: GO:0008152 ! metabolic process intersection_of: RO:0004007 CHEBI:17668 ! has primary input or output relationship: RO:0004007 CHEBI:17668 ! has primary input or output [Term] id: GO:0009188 name: ribonucleoside diphosphate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a ribonucleoside diphosphate, a compound consisting of a nucleobase linked to a ribose sugar esterified with diphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] synonym: "ribonucleoside diphosphate anabolism" EXACT [] synonym: "ribonucleoside diphosphate biosynthesis" EXACT [] synonym: "ribonucleoside diphosphate formation" EXACT [] synonym: "ribonucleoside diphosphate synthesis" EXACT [] is_a: GO:0009133 ! nucleoside diphosphate biosynthetic process is_a: GO:0009185 ! ribonucleoside diphosphate metabolic process intersection_of: GO:0009058 ! biosynthetic process intersection_of: RO:0004008 CHEBI:17668 ! has primary output relationship: RO:0004008 CHEBI:17668 ! has primary output [Term] id: GO:0009191 name: ribonucleoside diphosphate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of a ribonucleoside diphosphate, a compound consisting of a nucleobase linked to a ribose sugar esterified with diphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] synonym: "ribonucleoside diphosphate breakdown" EXACT [] synonym: "ribonucleoside diphosphate catabolism" EXACT [] synonym: "ribonucleoside diphosphate degradation" EXACT [] is_a: GO:0009134 ! nucleoside diphosphate catabolic process is_a: GO:0009185 ! ribonucleoside diphosphate metabolic process intersection_of: GO:0009056 ! catabolic process intersection_of: RO:0004009 CHEBI:17668 ! has primary input relationship: RO:0004009 CHEBI:17668 ! has primary input [Term] id: GO:0009201 name: ribonucleoside triphosphate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a ribonucleoside triphosphate, a compound consisting of a nucleobase linked to a ribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] synonym: "ribonucleoside triphosphate anabolism" EXACT [] synonym: "ribonucleoside triphosphate biosynthesis" EXACT [] synonym: "ribonucleoside triphosphate formation" EXACT [] synonym: "ribonucleoside triphosphate synthesis" EXACT [] is_a: GO:0009142 ! nucleoside triphosphate biosynthetic process intersection_of: GO:0009058 ! biosynthetic process intersection_of: RO:0004008 CHEBI:17972 ! has primary output relationship: RO:0004008 CHEBI:17972 ! has primary output [Term] id: GO:0009203 name: ribonucleoside triphosphate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of a ribonucleoside triphosphate, a compound consisting of a nucleobase linked to a ribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] synonym: "ribonucleoside triphosphate breakdown" EXACT [] synonym: "ribonucleoside triphosphate catabolism" EXACT [] synonym: "ribonucleoside triphosphate degradation" EXACT [] is_a: GO:0009143 ! nucleoside triphosphate catabolic process intersection_of: GO:0009056 ! catabolic process intersection_of: RO:0004009 CHEBI:17972 ! has primary input relationship: RO:0004009 CHEBI:17972 ! has primary input [Term] id: GO:0009205 name: purine ribonucleoside triphosphate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving purine ribonucleoside triphosphate, a compound consisting of a purine base linked to a ribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] synonym: "purine ribonucleoside triphosphate metabolism" EXACT [] is_a: GO:0009144 ! purine nucleoside triphosphate metabolic process intersection_of: GO:0008152 ! metabolic process intersection_of: RO:0004007 CHEBI:26398 ! has primary input or output relationship: RO:0004007 CHEBI:26398 ! has primary input or output [Term] id: GO:0009206 name: purine ribonucleoside triphosphate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of purine ribonucleoside triphosphate, a compound consisting of a purine base linked to a ribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] synonym: "purine ribonucleoside triphosphate anabolism" EXACT [] synonym: "purine ribonucleoside triphosphate biosynthesis" EXACT [] synonym: "purine ribonucleoside triphosphate formation" EXACT [] synonym: "purine ribonucleoside triphosphate synthesis" EXACT [] is_a: GO:0009145 ! purine nucleoside triphosphate biosynthetic process is_a: GO:0009201 ! ribonucleoside triphosphate biosynthetic process is_a: GO:0009205 ! purine ribonucleoside triphosphate metabolic process intersection_of: GO:0009058 ! biosynthetic process intersection_of: RO:0004008 CHEBI:26398 ! has primary output relationship: RO:0004008 CHEBI:26398 ! has primary output [Term] id: GO:0009207 name: purine ribonucleoside triphosphate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of purine ribonucleoside triphosphate, a compound consisting of a purine base linked to a ribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] synonym: "purine ribonucleoside triphosphate breakdown" EXACT [] synonym: "purine ribonucleoside triphosphate catabolism" EXACT [] synonym: "purine ribonucleoside triphosphate degradation" EXACT [] is_a: GO:0009146 ! purine nucleoside triphosphate catabolic process is_a: GO:0009203 ! ribonucleoside triphosphate catabolic process is_a: GO:0009205 ! purine ribonucleoside triphosphate metabolic process intersection_of: GO:0009056 ! catabolic process intersection_of: RO:0004009 CHEBI:26398 ! has primary input relationship: RO:0004009 CHEBI:26398 ! has primary input [Term] id: GO:0009247 name: glycolipid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of glycolipid, a class of 1,2-di-O-acylglycerols joined at oxygen 3 by a glycosidic linkage to a carbohydrate part (usually a mono-, di- or tri-saccharide)." [GOC:go_curators] synonym: "glycolipid anabolism" EXACT [] synonym: "glycolipid biosynthesis" EXACT [] synonym: "glycolipid formation" EXACT [] synonym: "glycolipid synthesis" EXACT [] xref: MetaCyc:PWY-401 is_a: GO:0006664 ! glycolipid metabolic process is_a: GO:0046467 ! membrane lipid biosynthetic process is_a: GO:1901137 ! carbohydrate derivative biosynthetic process intersection_of: GO:0009058 ! biosynthetic process intersection_of: RO:0004008 CHEBI:33563 ! has primary output relationship: RO:0004008 CHEBI:33563 ! has primary output property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/28573" xsd:anyURI [Term] id: GO:0009250 name: glucan biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of glucans, polysaccharides consisting only of glucose residues." [GOC:go_curators] synonym: "glucan anabolism" EXACT [] synonym: "glucan biosynthesis" EXACT [] synonym: "glucan formation" EXACT [] synonym: "glucan synthesis" EXACT [] is_a: GO:0000271 ! polysaccharide biosynthetic process is_a: GO:0044042 ! glucan metabolic process intersection_of: GO:0009058 ! biosynthetic process intersection_of: RO:0004008 CHEBI:37163 ! has primary output relationship: RO:0004008 CHEBI:37163 ! has primary output [Term] id: GO:0009251 name: glucan catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of glucans, polysaccharides consisting only of glucose residues." [GOC:go_curators] synonym: "glucan breakdown" EXACT [] synonym: "glucan catabolism" EXACT [] synonym: "glucan degradation" EXACT [] is_a: GO:0000272 ! polysaccharide catabolic process is_a: GO:0044042 ! glucan metabolic process intersection_of: GO:0009056 ! catabolic process intersection_of: RO:0004009 CHEBI:37163 ! has primary input relationship: RO:0004009 CHEBI:37163 ! has primary input [Term] id: GO:0009259 name: ribonucleotide metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a ribonucleotide, a compound consisting of ribonucleoside (a base linked to a ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732] synonym: "ribonucleotide metabolism" EXACT [] is_a: GO:0009117 ! nucleotide metabolic process is_a: GO:0019693 ! ribose phosphate metabolic process intersection_of: GO:0008152 ! metabolic process intersection_of: RO:0004007 CHEBI:26561 ! has primary input or output relationship: RO:0004007 CHEBI:26561 ! has primary input or output [Term] id: GO:0009260 name: ribonucleotide biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a ribonucleotide, a compound consisting of ribonucleoside (a base linked to a ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732] synonym: "ribonucleotide anabolism" EXACT [] synonym: "ribonucleotide biosynthesis" EXACT [] synonym: "ribonucleotide formation" EXACT [] synonym: "ribonucleotide synthesis" EXACT [] is_a: GO:0009165 ! nucleotide biosynthetic process is_a: GO:0009259 ! ribonucleotide metabolic process is_a: GO:0046390 ! ribose phosphate biosynthetic process intersection_of: GO:0009058 ! biosynthetic process intersection_of: RO:0004008 CHEBI:26561 ! has primary output relationship: RO:0004008 CHEBI:26561 ! has primary output [Term] id: GO:0009261 name: ribonucleotide catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of a ribonucleotide, a compound consisting of ribonucleoside (a base linked to a ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732] synonym: "ribonucleotide breakdown" EXACT [] synonym: "ribonucleotide catabolism" EXACT [] synonym: "ribonucleotide degradation" EXACT [] is_a: GO:0009166 ! nucleotide catabolic process is_a: GO:0009259 ! ribonucleotide metabolic process is_a: GO:1901136 ! carbohydrate derivative catabolic process intersection_of: GO:0009056 ! catabolic process intersection_of: RO:0004009 CHEBI:26561 ! has primary input relationship: RO:0004009 CHEBI:26561 ! has primary input [Term] id: GO:0009266 name: response to temperature stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a temperature stimulus." [GOC:hb] synonym: "response to thermal stimulus" EXACT [] is_a: GO:0009628 ! response to abiotic stimulus [Term] id: GO:0009295 name: nucleoid namespace: cellular_component def: "The region of a virus, bacterial cell, mitochondrion or chloroplast to which the nucleic acid is confined." [GOC:bm, GOC:ma, ISBN:3540076689] xref: Wikipedia:Nucleoid is_a: GO:0110165 ! cellular anatomical structure [Term] id: GO:0009306 name: protein secretion namespace: biological_process def: "The controlled release of proteins from a cell." [GOC:ai] synonym: "glycoprotein secretion" NARROW [] synonym: "protein secretion during cell fate commitment" NARROW [] synonym: "protein secretion resulting in cell fate commitment" NARROW [] is_a: GO:0015031 ! protein transport is_a: GO:0032940 ! secretion by cell is_a: GO:0035592 ! establishment of protein localization to extracellular region is_a: GO:0071692 ! protein localization to extracellular region intersection_of: GO:0046903 ! secretion intersection_of: RO:0004009 PR:000000001 ! has primary input protein [Term] id: GO:0009308 name: amine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving any organic compound that is weakly basic in character and contains an amino or a substituted amino group. Amines are called primary, secondary, or tertiary according to whether one, two, or three carbon atoms are attached to the nitrogen atom." [GOC:jl, ISBN:0198506732] subset: goslim_chembl subset: goslim_pir synonym: "amine metabolism" EXACT [] synonym: "cellular amine metabolic process" EXACT [] is_a: BFO:0000003 is_a: GO:0008152 ! metabolic process intersection_of: GO:0008152 ! metabolic process intersection_of: RO:0004007 CHEBI:32952 ! has primary input or output relationship: RO:0004007 CHEBI:32952 ! has primary input or output creation_date: 2009-07-15T11:55:44Z [Term] id: GO:0009309 name: amine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of any organic compound that is weakly basic in character and contains an amino or a substituted amino group. Amines are called primary, secondary, or tertiary according to whether one, two, or three carbon atoms are attached to the nitrogen atom." [GOC:jl, ISBN:0198506732] synonym: "amine anabolism" EXACT [] synonym: "amine biosynthesis" EXACT [] synonym: "amine formation" EXACT [] synonym: "amine synthesis" EXACT [] is_a: GO:0009058 ! biosynthetic process is_a: GO:0009308 ! amine metabolic process intersection_of: GO:0009058 ! biosynthetic process intersection_of: RO:0004008 CHEBI:32952 ! has primary output relationship: RO:0004008 CHEBI:32952 ! has primary output [Term] id: GO:0009310 name: amine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of any organic compound that is weakly basic in character and contains an amino or a substituted amino group. Amines are called primary, secondary, or tertiary according to whether one, two, or three carbon atoms are attached to the nitrogen atom." [GOC:jl, ISBN:0198506732] synonym: "amine breakdown" EXACT [] synonym: "amine catabolism" EXACT [] synonym: "amine degradation" EXACT [] is_a: GO:0009056 ! catabolic process is_a: GO:0009308 ! amine metabolic process intersection_of: GO:0009056 ! catabolic process intersection_of: RO:0004009 CHEBI:32952 ! has primary input relationship: RO:0004009 CHEBI:32952 ! has primary input [Term] id: GO:0009314 name: response to radiation namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an electromagnetic radiation stimulus. Electromagnetic radiation is a propagating wave in space with electric and magnetic components. These components oscillate at right angles to each other and to the direction of propagation." [GOC:jl, Wikipedia:Electromagnetic_radiation] comment: Note that 'radiation' refers to electromagnetic radiation of any wavelength. synonym: "response to electromagnetic radiation stimulus" EXACT [] synonym: "response to radiation stimulus" EXACT [] is_a: GO:0009628 ! response to abiotic stimulus [Term] id: GO:0009399 name: nitrogen fixation namespace: biological_process def: "The process in which nitrogen is taken from its relatively inert molecular form (N2) in the atmosphere and converted into ammonium, which is more biologically available." [PMID:32796519, PMID:36344435] xref: MetaCyc:N2FIX-PWY xref: Wikipedia:Nitrogen_fixation is_a: BFO:0000003 is_a: GO:0071941 ! nitrogen cycle metabolic process intersection_of: GO:0008152 ! metabolic process intersection_of: RO:0004008 CHEBI:28938 ! has primary output intersection_of: RO:0004009 CHEBI:17997 ! has primary input relationship: RO:0004008 CHEBI:28938 ! has primary output relationship: RO:0004009 CHEBI:17997 ! has primary input property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/27215" xsd:anyURI [Term] id: GO:0009411 name: response to UV namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ultraviolet radiation (UV light) stimulus. Ultraviolet radiation is electromagnetic radiation with a wavelength in the range of 10 to 380 nanometers." [GOC:hb] synonym: "response to ultraviolet light stimulus" EXACT [] synonym: "response to ultraviolet radiation stimulus" EXACT [] synonym: "response to UV light stimulus" EXACT [] synonym: "response to UV radiation stimulus" EXACT [] is_a: GO:0009416 ! response to light stimulus [Term] id: GO:0009414 name: response to water deprivation namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a water deprivation stimulus, prolonged deprivation of water." [GOC:lr] synonym: "drought tolerance" RELATED [] synonym: "response to dehydration" EXACT [] synonym: "response to drought" EXACT [] synonym: "response to thirst" EXACT [] is_a: GO:0006950 ! response to stress is_a: GO:0009415 ! response to water [Term] id: GO:0009415 name: response to water namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of water." [GOC:jl] synonym: "response to water stimulus" EXACT [GOC:dos] is_a: GO:0001101 ! response to acid chemical is_a: GO:0009628 ! response to abiotic stimulus is_a: GO:1901700 ! response to oxygen-containing compound intersection_of: GO:0050896 ! response to stimulus intersection_of: RO:0004009 CHEBI:15377 ! has primary input relationship: RO:0004009 CHEBI:15377 ! has primary input [Term] id: GO:0009416 name: response to light stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light." [GOC:go_curators, ISBN:0582227089] subset: goslim_plant is_a: BFO:0000003 is_a: GO:0009314 ! response to radiation intersection_of: GO:0050896 ! response to stimulus intersection_of: RO:0004009 CHEBI:30212 ! has primary input relationship: RO:0004009 CHEBI:30212 ! has primary input [Term] id: GO:0009448 name: gamma-aminobutyric acid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving gamma-aminobutyric acid (GABA, 4-aminobutyrate), an amino acid which acts as a neurotransmitter in some organisms." [ISBN:0198506732] comment: See also the biological process term 'neurotransmitter metabolic process ; GO:0042133'. synonym: "4-aminobutanoate metabolic process" EXACT [] synonym: "4-aminobutanoate metabolism" EXACT [] synonym: "4-aminobutyrate metabolic process" EXACT [] synonym: "4-aminobutyrate metabolism" EXACT [] synonym: "GABA metabolic process" EXACT [] synonym: "GABA metabolism" EXACT [] synonym: "gamma-aminobutyric acid metabolism" EXACT [] is_a: GO:0032787 ! monocarboxylic acid metabolic process is_a: GO:0170041 ! non-proteinogenic amino acid metabolic process intersection_of: GO:0008152 ! metabolic process intersection_of: RO:0004007 CHEBI:59888 ! has primary input or output relationship: RO:0004007 CHEBI:59888 ! has primary input or output [Term] id: GO:0009449 name: gamma-aminobutyric acid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of gamma-aminobutyric acid (GABA, 4-aminobutyrate), an amino acid which acts as a neurotransmitter in some organisms." [GOC:ai] comment: See also the biological process term 'neurotransmitter biosynthetic process ; GO:0042136'. synonym: "4-aminobutanoate biosynthesis" EXACT [] synonym: "4-aminobutanoate biosynthetic process" EXACT [] synonym: "4-aminobutyrate biosynthesis" EXACT [] synonym: "4-aminobutyrate biosynthetic process" EXACT [] synonym: "GABA biosynthesis" EXACT [] synonym: "GABA biosynthetic process" EXACT [] synonym: "gamma-aminobutyric acid anabolism" EXACT [] synonym: "gamma-aminobutyric acid biosynthesis" EXACT [] synonym: "gamma-aminobutyric acid formation" EXACT [] synonym: "gamma-aminobutyric acid synthesis" EXACT [] xref: Reactome:R-HSA-888568 "GABA synthesis" is_a: GO:0008652 ! amino acid biosynthetic process is_a: GO:0009448 ! gamma-aminobutyric acid metabolic process is_a: GO:0170043 ! non-proteinogenic amino acid biosynthetic process intersection_of: GO:0009058 ! biosynthetic process intersection_of: RO:0004008 CHEBI:59888 ! has primary output relationship: RO:0004008 CHEBI:59888 ! has primary output [Term] id: GO:0009450 name: gamma-aminobutyric acid catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of gamma-aminobutyric acid (GABA, 4-aminobutyrate), an amino acid which acts as a neurotransmitter in some organisms." [GOC:ai] comment: See also the biological process term 'neurotransmitter catabolic process ; GO:0042135'. synonym: "4-aminobutanoate catabolic process" EXACT [] synonym: "4-aminobutanoate catabolism" EXACT [] synonym: "4-aminobutyrate catabolic process" EXACT [] synonym: "4-aminobutyrate catabolism" EXACT [] synonym: "GABA catabolic process" EXACT [] synonym: "GABA catabolism" EXACT [] synonym: "gamma-aminobutyric acid breakdown" EXACT [] synonym: "gamma-aminobutyric acid catabolism" EXACT [] synonym: "gamma-aminobutyric acid degradation" EXACT [] xref: MetaCyc:4AMINOBUTMETAB-PWY xref: Reactome:R-HSA-916853 "Degradation of GABA" is_a: GO:0009063 ! amino acid catabolic process is_a: GO:0009448 ! gamma-aminobutyric acid metabolic process is_a: GO:0170044 ! non-proteinogenic amino acid catabolic process intersection_of: GO:0009056 ! catabolic process intersection_of: RO:0004009 CHEBI:59888 ! has primary input relationship: RO:0004009 CHEBI:59888 ! has primary input [Term] id: GO:0009507 name: chloroplast namespace: cellular_component def: "A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma." [ISBN:0471245208] subset: goslim_plant subset: goslim_plant_ribbon xref: Wikipedia:Chloroplast is_a: GO:0009536 ! plastid property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:28009 property_value: RO:0002161 NCBITaxon:33208 property_value: RO:0002161 NCBITaxon:4751 property_value: RO:0002161 NCBITaxon:554915 [Term] id: GO:0009508 name: plastid chromosome namespace: cellular_component def: "A circular DNA molecule containing plastid encoded genes." [ISBN:0943088399] is_a: GO:0005694 ! chromosome intersection_of: GO:0005694 ! chromosome intersection_of: BFO:0000050 GO:0009536 ! part of plastid relationship: BFO:0000050 GO:0042646 ! part of plastid nucleoid property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:28009 property_value: RO:0002161 NCBITaxon:33208 property_value: RO:0002161 NCBITaxon:4751 property_value: RO:0002161 NCBITaxon:554915 [Term] id: GO:0009526 name: plastid envelope namespace: cellular_component def: "The double lipid bilayer enclosing a plastid and separating its contents from the rest of the cytoplasm; includes the intermembrane space." [GOC:jy] is_a: GO:0031967 ! organelle envelope relationship: BFO:0000050 GO:0009536 ! part of plastid property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:28009 property_value: RO:0002161 NCBITaxon:33208 property_value: RO:0002161 NCBITaxon:4751 property_value: RO:0002161 NCBITaxon:554915 [Term] id: GO:0009527 name: plastid outer membrane namespace: cellular_component def: "The outer, i.e. cytoplasm-facing, lipid bilayer of the plastid envelope." [GOC:lr] is_a: GO:0031968 ! organelle outer membrane is_a: GO:0042170 ! plastid membrane intersection_of: GO:0016020 ! membrane intersection_of: RO:0002007 GO:0009536 ! bounding layer of plastid relationship: RO:0002007 GO:0009536 ! bounding layer of plastid property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:28009 property_value: RO:0002161 NCBITaxon:33208 property_value: RO:0002161 NCBITaxon:4751 property_value: RO:0002161 NCBITaxon:554915 [Term] id: GO:0009532 name: plastid stroma namespace: cellular_component def: "The proteinaceous ground substance of plastids." [ISBN:0943088399] is_a: GO:0110165 ! cellular anatomical structure relationship: BFO:0000050 GO:0009536 ! part of plastid property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:28009 property_value: RO:0002161 NCBITaxon:33208 property_value: RO:0002161 NCBITaxon:4751 property_value: RO:0002161 NCBITaxon:554915 [Term] id: GO:0009536 name: plastid namespace: cellular_component def: "Any member of a family of organelles found in the cytoplasm of plants and some protists, which are membrane-bounded and contain DNA. Plant plastids develop from a common type, the proplastid." [GOC:jl, ISBN:0198547684] subset: goslim_chembl subset: goslim_generic subset: goslim_pir subset: goslim_plant subset: goslim_plant_ribbon xref: Wikipedia:Plastid is_a: GO:0043231 ! intracellular membrane-bounded organelle relationship: BFO:0000050 GO:0005737 ! part of cytoplasm property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:28009 property_value: RO:0002161 NCBITaxon:33208 property_value: RO:0002161 NCBITaxon:4751 property_value: RO:0002161 NCBITaxon:554915 [Term] id: GO:0009547 name: plastid ribosome namespace: cellular_component def: "A ribosome contained within a plastid." [GOC:tair_curators] is_a: GO:0000313 ! organellar ribosome intersection_of: GO:0005840 ! ribosome intersection_of: BFO:0000050 GO:0009536 ! part of plastid relationship: BFO:0000050 GO:0009532 ! part of plastid stroma property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:28009 property_value: RO:0002161 NCBITaxon:33208 property_value: RO:0002161 NCBITaxon:4751 property_value: RO:0002161 NCBITaxon:554915 [Term] id: GO:0009566 name: fertilization namespace: biological_process def: "The union of gametes of opposite sexes during the process of sexual reproduction to form a zygote. It involves the fusion of the gametic nuclei (karyogamy) and cytoplasm (plasmogamy)." [GOC:tb, ISBN:0198506732] synonym: "syngamy" EXACT [] xref: Wikipedia:Fertilisation is_a: BFO:0000003 is_a: GO:0022414 ! reproductive process intersection_of: GO:0022414 ! reproductive process intersection_of: RO:0002297 CL:0010017 ! results in formation of anatomical entity zygote intersection_of: RO:0012008 GO:0043073 ! results in fusion of germ cell nucleus relationship: BFO:0000050 GO:0019953 ! part of sexual reproduction relationship: RO:0002297 CL:0010017 ! results in formation of anatomical entity zygote relationship: RO:0012008 GO:0043073 ! results in fusion of germ cell nucleus property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/20176" xsd:anyURI [Term] id: GO:0009570 name: chloroplast stroma namespace: cellular_component def: "The space enclosed by the double membrane of a chloroplast but excluding the thylakoid space. It contains DNA, ribosomes and some temporary products of photosynthesis." [ISBN:0198547684] is_a: GO:0009532 ! plastid stroma relationship: BFO:0000050 GO:0009507 ! part of chloroplast property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:28009 property_value: RO:0002161 NCBITaxon:33208 property_value: RO:0002161 NCBITaxon:4751 property_value: RO:0002161 NCBITaxon:554915 [Term] id: GO:0009581 name: detection of external stimulus namespace: biological_process def: "The series of events in which an external stimulus is received by a cell and converted into a molecular signal." [GOC:hb] synonym: "perception of external stimulus" RELATED [] is_a: GO:0009605 ! response to external stimulus is_a: GO:0051606 ! detection of stimulus [Term] id: GO:0009582 name: detection of abiotic stimulus namespace: biological_process def: "The series of events in which an (non-living) abiotic stimulus is received by a cell and converted into a molecular signal." [GOC:hb] synonym: "perception of abiotic stimulus" RELATED [] is_a: GO:0009628 ! response to abiotic stimulus is_a: GO:0051606 ! detection of stimulus [Term] id: GO:0009583 name: detection of light stimulus namespace: biological_process def: "The series of events in which a light stimulus (in the form of photons) is received and converted into a molecular signal." [GOC:go_curators] synonym: "detection of light" EXACT [] synonym: "perception of light" RELATED [] is_a: GO:0009416 ! response to light stimulus is_a: GO:0009581 ! detection of external stimulus is_a: GO:0009582 ! detection of abiotic stimulus [Term] id: GO:0009584 name: detection of visible light namespace: biological_process def: "The series of events in which a visible light stimulus is received by a cell and converted into a molecular signal. A visible light stimulus is electromagnetic radiation that can be perceived visually by an organism; for organisms lacking a visual system, this can be defined as light with a wavelength within the range 380 to 780 nm." [GOC:go_curators, ISBN:0198506732] synonym: "perception of visible light" RELATED [] is_a: GO:0009583 ! detection of light stimulus [Term] id: GO:0009589 name: detection of UV namespace: biological_process def: "The series of events in which an ultraviolet radiation (UV light) stimulus is received and converted into a molecular signal. Ultraviolet radiation is electromagnetic radiation with a wavelength in the range of 10 to 380 nanometers." [GOC:dos, GOC:go_curators, GOC:hb, ISBN:0198506732] synonym: "detection of ultraviolet light stimulus" EXACT [] synonym: "detection of ultraviolet radiation stimulus" EXACT [] synonym: "detection of UV light stimulus" EXACT [] synonym: "detection of UV radiation stimulus" EXACT [] synonym: "perception of UV" RELATED [] is_a: GO:0009411 ! response to UV is_a: GO:0009583 ! detection of light stimulus [Term] id: GO:0009590 name: detection of gravity namespace: biological_process def: "The series of events in which a gravitational stimulus is received and converted into a molecular signal." [GOC:dos, GOC:hb] synonym: "perception of gravity" RELATED [] is_a: GO:0009581 ! detection of external stimulus is_a: GO:0009582 ! detection of abiotic stimulus is_a: GO:0009629 ! response to gravity [Term] id: GO:0009593 name: detection of chemical stimulus namespace: biological_process def: "The series of events in which a chemical stimulus is received by a cell and converted into a molecular signal." [GOC:jl] synonym: "chemoperception" EXACT [] synonym: "chemoreception" RELATED [] synonym: "detection of chemical substance" EXACT [] synonym: "perception of chemical stimulus" RELATED [] synonym: "perception of chemical substance" RELATED [] is_a: GO:0051606 ! detection of stimulus relationship: BFO:0000050 GO:0042221 ! part of response to chemical [Term] id: GO:0009605 name: response to external stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an external stimulus." [GOC:hb] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_annotate subset: goslim_drosophila subset: goslim_plant synonym: "response to environmental stimulus" EXACT [] is_a: GO:0050896 ! response to stimulus [Term] id: GO:0009607 name: response to biotic stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a biotic stimulus, a stimulus caused or produced by a living organism." [GOC:hb] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_annotate subset: goslim_metagenomics subset: goslim_plant synonym: "response to biotic stress" NARROW [] is_a: GO:0050896 ! response to stimulus [Term] id: GO:0009611 name: response to wounding namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to the organism." [GOC:go_curators] synonym: "physiological response to wounding" EXACT [] is_a: GO:0006950 ! response to stress [Term] id: GO:0009612 name: response to mechanical stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mechanical stimulus." [GOC:hb] synonym: "chemi-mechanical coupling" RELATED [] synonym: "mechanical stimulus response" EXACT [] is_a: GO:0009605 ! response to external stimulus is_a: GO:0009628 ! response to abiotic stimulus [Term] id: GO:0009617 name: response to bacterium namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a bacterium." [GOC:hb] synonym: "response to bacteria" EXACT [] xref: Reactome:R-HSA-9824439 "Bacterial Infection Pathways" is_a: BFO:0000003 is_a: GO:0051707 ! response to other organism intersection_of: GO:0050896 ! response to stimulus intersection_of: RO:0004009 NCBITaxon:2 ! has primary input Bacteria relationship: RO:0004009 NCBITaxon:2 ! has primary input Bacteria property_value: RO:0002161 NCBITaxon:4895 [Term] id: GO:0009620 name: response to fungus namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a fungus." [GOC:hb] synonym: "response to fungi" EXACT [] is_a: BFO:0000003 is_a: GO:0051707 ! response to other organism intersection_of: GO:0050896 ! response to stimulus intersection_of: RO:0004009 NCBITaxon:4751 ! has primary input Fungi relationship: RO:0004009 NCBITaxon:4751 ! has primary input Fungi property_value: RO:0002161 NCBITaxon:4895 [Term] id: GO:0009628 name: response to abiotic stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an abiotic (not derived from living organisms) stimulus." [GOC:hb] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_annotate subset: goslim_metagenomics subset: goslim_plant synonym: "response to abiotic stress" NARROW [] is_a: GO:0050896 ! response to stimulus property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/16572" xsd:anyURI [Term] id: GO:0009629 name: response to gravity namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gravitational stimulus." [GOC:hb] synonym: "response to gravitational stimulus" EXACT [] is_a: GO:0009628 ! response to abiotic stimulus [Term] id: GO:0009636 name: response to toxic substance namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a toxic stimulus." [GOC:lr] subset: goslim_chembl synonym: "detoxification response" NARROW [] synonym: "toxin resistance" RELATED [] synonym: "toxin susceptibility/resistance" RELATED [] is_a: GO:0042221 ! response to chemical [Term] id: GO:0009653 name: anatomical structure morphogenesis namespace: biological_process def: "The process in which anatomical structures are generated and organized. Morphogenesis pertains to the creation of form." [GOC:go_curators, ISBN:0521436125] synonym: "anatomical structure organization" EXACT [] synonym: "embryogenesis and morphogenesis" BROAD [] synonym: "morphogenesis" EXACT [] xref: Wikipedia:Morphogenesis is_a: GO:0032502 ! developmental process disjoint_from: GO:0048856 ! anatomical structure development disjoint_from: GO:0071695 ! anatomical structure maturation relationship: BFO:0000050 GO:0048856 ! part of anatomical structure development [Term] id: GO:0009657 name: plastid organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a plastid." [GOC:mah] subset: goslim_pir synonym: "plastid organisation" EXACT [] synonym: "plastid organization and biogenesis" RELATED [GOC:mah] is_a: GO:0006996 ! organelle organization intersection_of: GO:0016043 ! cellular component organization intersection_of: RO:0002592 GO:0009536 ! results in organization of plastid relationship: RO:0002592 GO:0009536 ! results in organization of plastid property_value: RO:0002161 NCBITaxon:28009 property_value: RO:0002161 NCBITaxon:33208 property_value: RO:0002161 NCBITaxon:4751 property_value: RO:0002161 NCBITaxon:554915 [Term] id: GO:0009658 name: chloroplast organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the chloroplast." [GOC:jid] synonym: "chloroplast organisation" EXACT [] synonym: "chloroplast organization and biogenesis" RELATED [GOC:mah] is_a: GO:0009657 ! plastid organization intersection_of: GO:0016043 ! cellular component organization intersection_of: RO:0002592 GO:0009507 ! results in organization of chloroplast relationship: RO:0002592 GO:0009507 ! results in organization of chloroplast property_value: RO:0002161 NCBITaxon:28009 property_value: RO:0002161 NCBITaxon:33208 property_value: RO:0002161 NCBITaxon:4751 property_value: RO:0002161 NCBITaxon:554915 [Term] id: GO:0009665 name: plastid inheritance namespace: biological_process def: "The partitioning of plastids between daughter cells at cell division." [GOC:mah] is_a: GO:0009657 ! plastid organization is_a: GO:0048308 ! organelle inheritance intersection_of: GO:0048308 ! organelle inheritance intersection_of: results_in_distribution_of GO:0009536 ! plastid relationship: results_in_distribution_of GO:0009536 ! plastid property_value: RO:0002161 NCBITaxon:28009 property_value: RO:0002161 NCBITaxon:33208 property_value: RO:0002161 NCBITaxon:4751 property_value: RO:0002161 NCBITaxon:554915 [Term] id: GO:0009666 name: plastid outer membrane organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the outer membrane of a plastid." [GOC:ai, GOC:dph, GOC:jl, GOC:mah] synonym: "plastid outer membrane organisation" EXACT [] synonym: "plastid outer membrane organization and biogenesis" RELATED [GOC:mah] is_a: GO:0009668 ! plastid membrane organization intersection_of: GO:0016043 ! cellular component organization intersection_of: RO:0002592 GO:0009527 ! results in organization of plastid outer membrane relationship: RO:0002592 GO:0009527 ! results in organization of plastid outer membrane property_value: RO:0002161 NCBITaxon:28009 property_value: RO:0002161 NCBITaxon:33208 property_value: RO:0002161 NCBITaxon:4751 property_value: RO:0002161 NCBITaxon:554915 [Term] id: GO:0009668 name: plastid membrane organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of either of the lipid bilayers surrounding a plastid." [GOC:ai, GOC:dph, GOC:jl, GOC:mah] synonym: "plastid membrane organisation" EXACT [] synonym: "plastid membrane organization and biogenesis" RELATED [GOC:mah] is_a: GO:0061024 ! membrane organization intersection_of: GO:0016043 ! cellular component organization intersection_of: RO:0002592 GO:0042170 ! results in organization of plastid membrane relationship: BFO:0000050 GO:0009657 ! part of plastid organization relationship: RO:0002592 GO:0042170 ! results in organization of plastid membrane property_value: RO:0002161 NCBITaxon:28009 property_value: RO:0002161 NCBITaxon:33208 property_value: RO:0002161 NCBITaxon:4751 property_value: RO:0002161 NCBITaxon:554915 [Term] id: GO:0009707 name: chloroplast outer membrane namespace: cellular_component def: "The outer, i.e. cytoplasm-facing, lipid bilayer of the chloroplast envelope." [GOC:tb] synonym: "chloroplast outer envelope" EXACT [] is_a: GO:0009527 ! plastid outer membrane is_a: GO:0031969 ! chloroplast membrane intersection_of: GO:0016020 ! membrane intersection_of: RO:0002007 GO:0009507 ! bounding layer of chloroplast relationship: RO:0002007 GO:0009507 ! bounding layer of chloroplast property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:28009 property_value: RO:0002161 NCBITaxon:33208 property_value: RO:0002161 NCBITaxon:4751 property_value: RO:0002161 NCBITaxon:554915 [Term] id: GO:0009712 name: catechol-containing compound metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a compound containing a pyrocatechol (1,2-benzenediol) nucleus or substituent." [GOC:sm, ISBN:0198547684] synonym: "catechol metabolic process" RELATED [] synonym: "catechol metabolism" RELATED [] is_a: GO:0018958 ! phenol-containing compound metabolic process intersection_of: GO:0008152 ! metabolic process intersection_of: RO:0004007 CHEBI:33566 ! has primary input or output relationship: RO:0004007 CHEBI:33566 ! has primary input or output [Term] id: GO:0009713 name: catechol-containing compound biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of catechol-containing compounds. Catechol is a compound containing a pyrocatechol nucleus or substituent." [GOC:go_curators] synonym: "catechol anabolism" RELATED [] synonym: "catechol biosynthesis" RELATED [] synonym: "catechol biosynthetic process" RELATED [] synonym: "catechol formation" RELATED [] synonym: "catechol synthesis" RELATED [] is_a: GO:0009712 ! catechol-containing compound metabolic process is_a: GO:0046189 ! phenol-containing compound biosynthetic process intersection_of: GO:0009058 ! biosynthetic process intersection_of: RO:0004008 CHEBI:33566 ! has primary output relationship: RO:0004008 CHEBI:33566 ! has primary output [Term] id: GO:0009719 name: response to endogenous stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus arising within the organism." [GOC:sm] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_annotate subset: goslim_plant is_a: GO:0050896 ! response to stimulus [Term] id: GO:0009725 name: response to hormone namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hormone stimulus." [GOC:jl] synonym: "growth regulator" RELATED [] synonym: "response to hormone stimulus" EXACT [GOC:dos] is_a: GO:0009719 ! response to endogenous stimulus is_a: GO:0042221 ! response to chemical property_value: RO:0002161 NCBITaxon:4751 [Term] id: GO:0009743 name: response to carbohydrate namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a carbohydrate stimulus." [GOC:jl] synonym: "response to carbohydrate stimulus" EXACT [GOC:dos] is_a: GO:1901700 ! response to oxygen-containing compound intersection_of: GO:0050896 ! response to stimulus intersection_of: RO:0004009 CHEBI:16646 ! has primary input relationship: RO:0004009 CHEBI:16646 ! has primary input [Term] id: GO:0009746 name: response to hexose namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hexose stimulus." [GOC:jl] synonym: "response to hexose stimulus" EXACT [GOC:dos] is_a: GO:0034284 ! response to monosaccharide intersection_of: GO:0050896 ! response to stimulus intersection_of: RO:0004009 CHEBI:18133 ! has primary input relationship: RO:0004009 CHEBI:18133 ! has primary input [Term] id: GO:0009749 name: response to glucose namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucose stimulus." [GOC:jl] synonym: "response to glucose stimulus" EXACT [GOC:dos] is_a: GO:0009746 ! response to hexose intersection_of: GO:0050896 ! response to stimulus intersection_of: RO:0004009 CHEBI:4167 ! has primary input relationship: RO:0004009 CHEBI:4167 ! has primary input [Term] id: GO:0009755 name: hormone-mediated signaling pathway namespace: biological_process def: "The series of molecular signals mediated by the detection of a hormone." [GOC:sm] synonym: "hormone mediated signalling" EXACT [] is_a: GO:0007165 ! signal transduction relationship: BFO:0000050 GO:0032870 ! part of cellular response to hormone stimulus property_value: RO:0002161 NCBITaxon:4751 [Term] id: GO:0009786 name: regulation of asymmetric cell division namespace: biological_process def: "Any process that modulates the frequency, rate or extent of asymmetric cell division." [GOC:lr] is_a: GO:0051302 ! regulation of cell division intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0008356 ! regulates asymmetric cell division relationship: RO:0002211 GO:0008356 ! regulates asymmetric cell division [Term] id: GO:0009790 name: embryo development namespace: biological_process def: "The process whose specific outcome is the progression of an embryo from its formation until the end of its embryonic life stage. The end of the embryonic stage is organism-specific. For example, for mammals, the process would begin with zygote formation and end with birth. For insects, the process would begin at zygote formation and end with larval hatching. For plant zygotic embryos, this would be from zygote formation to the end of seed dormancy. For plant vegetative embryos, this would be from the initial determination of the cell or group of cells to form an embryo until the point when the embryo becomes independent of the parent plant." [GOC:go_curators, GOC:isa_complete, GOC:mtg_sensu] subset: gocheck_do_not_annotate subset: goslim_chembl subset: goslim_plant synonym: "embryogenesis" EXACT [] synonym: "embryogenesis and morphogenesis" BROAD [] synonym: "embryonal development" EXACT [] xref: Reactome:R-HSA-5619507 "Activation of HOX genes during differentiation" xref: Wikipedia:Embryogenesis is_a: GO:0007275 ! multicellular organism development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0000922 ! results in development of embryo relationship: RO:0002296 UBERON:0000922 ! results in development of embryo property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0009791 name: post-embryonic development namespace: biological_process def: "The process whose specific outcome is the progression of the organism over time, from the completion of embryonic development to the mature structure. See embryonic development." [GOC:go_curators] subset: goslim_plant is_a: GO:0032501 ! multicellular organismal process relationship: BFO:0000050 GO:0007275 ! part of multicellular organism development property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0009792 name: embryo development ending in birth or egg hatching namespace: biological_process def: "The process whose specific outcome is the progression of an embryo over time, from zygote formation until the end of the embryonic life stage. The end of the embryonic life stage is organism-specific and may be somewhat arbitrary; for mammals it is usually considered to be birth, for insects the hatching of the first instar larva from the eggshell." [GOC:go_curators, GOC:isa_complete, GOC:mtg_sensu] synonym: "embryogenesis" BROAD [] is_a: GO:0009790 ! embryo development relationship: RO:0002162 NCBITaxon:33208 ! in taxon Metazoa [Term] id: GO:0009798 name: axis specification namespace: biological_process def: "The establishment, maintenance and elaboration of a pattern along a line or around a point." [GOC:dph, GOC:go_curators, GOC:isa_complete] synonym: "axis determination" RELATED [] is_a: GO:0007389 ! pattern specification process property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0009880 name: embryonic pattern specification namespace: biological_process def: "The process that results in the patterns of cell differentiation that will arise in an embryo." [GOC:go_curators, ISBN:0521436125] synonym: "embryonic pattern biosynthesis" BROAD [] synonym: "embryonic pattern formation" BROAD [] synonym: "ventral/lateral system" RELATED [] is_a: GO:0007389 ! pattern specification process relationship: BFO:0000050 GO:0009790 ! part of embryo development property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0009886 name: post-embryonic animal morphogenesis namespace: biological_process def: "The process, occurring after animal embryonic development, by which anatomical structures are generated and organized." [GOC:go_curators] synonym: "post-embryonic morphogenesis of an anatomical structure" EXACT [] is_a: GO:0009653 ! anatomical structure morphogenesis relationship: BFO:0000050 GO:0009791 ! part of post-embryonic development property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0009887 name: animal organ morphogenesis namespace: biological_process def: "Morphogenesis of an animal organ. An organ is defined as a tissue or set of tissues that work together to perform a specific function or functions. Morphogenesis is the process in which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions." [GOC:dgh, GOC:go_curators, ISBN:0471245208, ISBN:0721662544] synonym: "histogenesis and organogenesis" BROAD [] is_a: BFO:0000003 is_a: GO:0009653 ! anatomical structure morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0000062 ! results in morphogenesis of organ relationship: BFO:0000050 GO:0048513 ! part of animal organ development relationship: RO:0002162 NCBITaxon:6072 ! in taxon Eumetazoa relationship: RO:0002298 UBERON:0000062 ! results in morphogenesis of organ [Term] id: GO:0009888 name: tissue development namespace: biological_process def: "The process whose specific outcome is the progression of a tissue over time, from its formation to the mature structure." [ISBN:0471245208] synonym: "histogenesis" EXACT [] synonym: "histogenesis and organogenesis" BROAD [] xref: Wikipedia:Histogenesis is_a: GO:0048856 ! anatomical structure development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0000479 ! results in development of tissue relationship: RO:0002162 NCBITaxon:2759 ! in taxon Eukaryota relationship: RO:0002296 UBERON:0000479 ! results in development of tissue property_value: RO:0002161 NCBITaxon:147554 property_value: RO:0002161 NCBITaxon:33630 property_value: RO:0002161 NCBITaxon:33682 property_value: RO:0002161 NCBITaxon:38254 property_value: RO:0002161 NCBITaxon:4891 [Term] id: GO:0009889 name: regulation of biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances." [GOC:go_curators] subset: gocheck_do_not_annotate synonym: "regulation of anabolism" EXACT [] synonym: "regulation of biosynthesis" EXACT [] synonym: "regulation of formation" EXACT [] synonym: "regulation of synthesis" EXACT [] is_a: GO:0019222 ! regulation of metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0009058 ! regulates biosynthetic process relationship: RO:0002211 GO:0009058 ! regulates biosynthetic process [Term] id: GO:0009890 name: negative regulation of biosynthetic process namespace: biological_process def: "Any process that stops, prevents, or reduces the rate of the chemical reactions and pathways resulting in the formation of substances." [GOC:go_curators] synonym: "down regulation of biosynthetic process" EXACT [] synonym: "down-regulation of biosynthetic process" EXACT [] synonym: "downregulation of biosynthetic process" EXACT [] synonym: "inhibition of biosynthetic process" NARROW [] synonym: "negative regulation of anabolism" EXACT [] synonym: "negative regulation of biosynthesis" EXACT [] synonym: "negative regulation of formation" EXACT [] synonym: "negative regulation of synthesis" EXACT [] is_a: GO:0009889 ! regulation of biosynthetic process is_a: GO:0009892 ! negative regulation of metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0009058 ! negatively regulates biosynthetic process relationship: RO:0002212 GO:0009058 ! negatively regulates biosynthetic process [Term] id: GO:0009891 name: positive regulation of biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances." [GOC:go_curators] synonym: "activation of biosynthetic process" NARROW [] synonym: "positive regulation of anabolism" EXACT [] synonym: "positive regulation of biosynthesis" EXACT [] synonym: "positive regulation of formation" EXACT [] synonym: "positive regulation of synthesis" EXACT [] synonym: "stimulation of biosynthetic process" NARROW [] synonym: "up regulation of biosynthetic process" EXACT [] synonym: "up-regulation of biosynthetic process" EXACT [] synonym: "upregulation of biosynthetic process" EXACT [] is_a: GO:0009889 ! regulation of biosynthetic process is_a: GO:0009893 ! positive regulation of metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0009058 ! positively regulates biosynthetic process relationship: RO:0002213 GO:0009058 ! positively regulates biosynthetic process [Term] id: GO:0009892 name: negative regulation of metabolic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism." [GOC:go_curators] synonym: "down regulation of metabolic process" EXACT [] synonym: "down-regulation of metabolic process" EXACT [] synonym: "downregulation of metabolic process" EXACT [] synonym: "inhibition of metabolic process" NARROW [] synonym: "inhibition of organismal metabolic process" NARROW [] synonym: "negative regulation of metabolism" EXACT [] synonym: "negative regulation of multicellular organismal metabolic process" NARROW [] synonym: "negative regulation of organismal metabolism" EXACT [] is_a: GO:0019222 ! regulation of metabolic process is_a: GO:0048523 ! negative regulation of cellular process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0008152 ! negatively regulates metabolic process relationship: RO:0002212 GO:0008152 ! negatively regulates metabolic process [Term] id: GO:0009893 name: positive regulation of metabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism." [GOC:go_curators] synonym: "activation of metabolic process" NARROW [] synonym: "positive regulation of metabolism" EXACT [] synonym: "positive regulation of multicellular organismal metabolic process" NARROW [] synonym: "positive regulation of organismal metabolism" NARROW [] synonym: "stimulation of metabolic process" NARROW [] synonym: "stimulation of organismal metabolic process" NARROW [] synonym: "up regulation of metabolic process" EXACT [] synonym: "up-regulation of metabolic process" EXACT [] synonym: "up-regulation of organismal metabolic process" NARROW [] synonym: "upregulation of metabolic process" EXACT [] is_a: GO:0019222 ! regulation of metabolic process is_a: GO:0048522 ! positive regulation of cellular process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0008152 ! positively regulates metabolic process relationship: RO:0002213 GO:0008152 ! positively regulates metabolic process [Term] id: GO:0009894 name: regulation of catabolic process namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of substances." [GOC:go_curators] subset: gocheck_do_not_annotate synonym: "regulation of breakdown" EXACT [] synonym: "regulation of catabolism" EXACT [] synonym: "regulation of degradation" EXACT [] is_a: GO:0019222 ! regulation of metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0009056 ! regulates catabolic process relationship: RO:0002211 GO:0009056 ! regulates catabolic process [Term] id: GO:0009895 name: negative regulation of catabolic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances." [GOC:go_curators] synonym: "down regulation of catabolic process" EXACT [] synonym: "down-regulation of catabolic process" EXACT [] synonym: "downregulation of catabolic process" EXACT [] synonym: "inhibition of catabolic process" NARROW [] synonym: "negative regulation of breakdown" EXACT [] synonym: "negative regulation of catabolism" EXACT [] synonym: "negative regulation of degradation" EXACT [] is_a: GO:0009892 ! negative regulation of metabolic process is_a: GO:0009894 ! regulation of catabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0009056 ! negatively regulates catabolic process relationship: RO:0002212 GO:0009056 ! negatively regulates catabolic process [Term] id: GO:0009896 name: positive regulation of catabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances." [GOC:go_curators] synonym: "activation of catabolic process" NARROW [] synonym: "positive regulation of breakdown" EXACT [] synonym: "positive regulation of catabolism" EXACT [] synonym: "positive regulation of degradation" EXACT [] synonym: "stimulation of catabolic process" NARROW [] synonym: "up regulation of catabolic process" EXACT [] synonym: "up-regulation of catabolic process" EXACT [] synonym: "upregulation of catabolic process" EXACT [] is_a: GO:0009893 ! positive regulation of metabolic process is_a: GO:0009894 ! regulation of catabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0009056 ! positively regulates catabolic process relationship: RO:0002213 GO:0009056 ! positively regulates catabolic process [Term] id: GO:0009902 name: chloroplast relocation namespace: biological_process def: "The process in which chloroplasts in photosynthetic cells migrate toward illuminated sites to optimize photosynthesis and move away from excessively illuminated areas to protect the photosynthetic machinery." [PMID:11309623] synonym: "chloroplast movement" EXACT [GOC:tb, PMID:18715957] is_a: GO:0009658 ! chloroplast organization is_a: GO:0019750 ! chloroplast localization is_a: GO:0051667 ! establishment of plastid localization intersection_of: GO:0051234 ! establishment of localization intersection_of: RO:0004009 GO:0009507 ! has primary input chloroplast property_value: RO:0002161 NCBITaxon:28009 property_value: RO:0002161 NCBITaxon:33208 property_value: RO:0002161 NCBITaxon:4751 property_value: RO:0002161 NCBITaxon:554915 [Term] id: GO:0009913 name: epidermal cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of an epidermal cell, any of the cells making up the epidermis." [GOC:dph, GOC:go_curators, GOC:mtg_sensu, GOC:sdb_2009, GOC:tb] synonym: "hypodermal cell differentiation" RELATED [GOC:kmv, GOC:rk] is_a: GO:0030855 ! epithelial cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000362 ! results in acquisition of features of epidermal cell relationship: BFO:0000050 GO:0008544 ! part of epidermis development relationship: RO:0002315 CL:0000362 ! results in acquisition of features of epidermal cell [Term] id: GO:0009914 name: hormone transport namespace: biological_process def: "The directed movement of hormones into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:tb] subset: goslim_pir is_a: GO:0006810 ! transport is_a: GO:0010817 ! regulation of hormone levels [Term] id: GO:0009941 name: chloroplast envelope namespace: cellular_component def: "The double lipid bilayer enclosing the chloroplast and separating its contents from the rest of the cytoplasm; includes the intermembrane space." [GOC:tb] is_a: GO:0009526 ! plastid envelope relationship: BFO:0000050 GO:0009507 ! part of chloroplast property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:28009 property_value: RO:0002161 NCBITaxon:33208 property_value: RO:0002161 NCBITaxon:4751 property_value: RO:0002161 NCBITaxon:554915 [Term] id: GO:0009948 name: anterior/posterior axis specification namespace: biological_process def: "The establishment, maintenance and elaboration of the anterior/posterior axis. The anterior-posterior axis is defined by a line that runs from the head or mouth of an organism to the tail or opposite end of the organism." [GOC:dph, GOC:go_curators, GOC:tb] synonym: "anterior/posterior axis determination" RELATED [GOC:dph] is_a: GO:0009798 ! axis specification relationship: BFO:0000050 GO:0009952 ! part of anterior/posterior pattern specification property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0009952 name: anterior/posterior pattern specification namespace: biological_process def: "The regionalization process in which specific areas of cell differentiation are determined along the anterior-posterior axis. The anterior-posterior axis is defined by a line that runs from the head or mouth of an organism to the tail or opposite end of the organism." [GOC:dph, GOC:go_curators, GOC:isa_complete, GOC:tb] synonym: "anterior/posterior pattern formation" RELATED [] is_a: GO:0003002 ! regionalization property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0009966 name: regulation of signal transduction namespace: biological_process def: "Any process that modulates the frequency, rate or extent of signal transduction." [GOC:sm] synonym: "regulation of signaling pathway" RELATED [] synonym: "regulation of signalling pathway" RELATED [GOC:mah] is_a: GO:0010646 ! regulation of cell communication is_a: GO:0023051 ! regulation of signaling is_a: GO:0048583 ! regulation of response to stimulus intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0007165 ! regulates signal transduction relationship: RO:0002211 GO:0007165 ! regulates signal transduction [Term] id: GO:0009967 name: positive regulation of signal transduction namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of signal transduction." [GOC:sm] synonym: "activation of signal transduction" NARROW [] synonym: "positive regulation of signaling pathway" RELATED [] synonym: "positive regulation of signalling pathway" RELATED [GOC:mah] synonym: "stimulation of signal transduction" NARROW [] synonym: "up regulation of signal transduction" EXACT [] synonym: "up-regulation of signal transduction" EXACT [] synonym: "upregulation of signal transduction" EXACT [] is_a: GO:0009966 ! regulation of signal transduction is_a: GO:0010647 ! positive regulation of cell communication is_a: GO:0023056 ! positive regulation of signaling is_a: GO:0048584 ! positive regulation of response to stimulus intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0007165 ! positively regulates signal transduction relationship: RO:0002213 GO:0007165 ! positively regulates signal transduction [Term] id: GO:0009968 name: negative regulation of signal transduction namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction." [GOC:sm] synonym: "down regulation of signal transduction" EXACT [] synonym: "down-regulation of signal transduction" EXACT [] synonym: "downregulation of signal transduction" EXACT [] synonym: "inhibition of signal transduction" NARROW [] synonym: "negative regulation of signaling pathway" RELATED [] synonym: "negative regulation of signalling pathway" RELATED [GOC:mah] xref: Reactome:R-HSA-8849472 "PTK6 Down-Regulation" is_a: GO:0009966 ! regulation of signal transduction is_a: GO:0010648 ! negative regulation of cell communication is_a: GO:0023057 ! negative regulation of signaling is_a: GO:0048585 ! negative regulation of response to stimulus intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0007165 ! negatively regulates signal transduction relationship: RO:0002212 GO:0007165 ! negatively regulates signal transduction [Term] id: GO:0009977 name: proton motive force dependent protein transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of proteins from one side of a membrane to the other. Transportation is dependent on pH gradient across the membrane." [PMID:11526245, PMID:25494301] synonym: "arginine targeting transmembrane transporter activity" EXACT [] synonym: "delta-pH-dependent protein transporter activity" EXACT [] synonym: "pH-dependent protein transporter activity" EXACT [] synonym: "twin-arginine targeting transmembrane transporter activity" EXACT [] is_a: GO:0008320 ! protein transmembrane transporter activity is_a: GO:0015291 ! secondary active transmembrane transporter activity intersection_of: GO:0015291 ! secondary active transmembrane transporter activity intersection_of: RO:0002342 GO:0016020 ! results in transport across membrane intersection_of: RO:0004009 PR:000000001 ! has primary input protein [Term] id: GO:0009987 name: cellular process namespace: biological_process def: "Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:go_curators, GOC:isa_complete] comment: This term should not be used for direct annotation. It should be possible to make a more specific annotation to one of the children of this term. subset: gocheck_do_not_annotate subset: goslim_plant synonym: "cell growth and/or maintenance" NARROW [] synonym: "cell physiology" EXACT [] synonym: "cellular physiological process" EXACT [] synonym: "single-organism cellular process" RELATED [] is_a: GO:0008150 ! biological_process disjoint_from: GO:0044848 ! biological phase creation_date: 2012-12-11T16:56:55Z [Term] id: GO:0009992 name: intracellular water homeostasis namespace: biological_process def: "A homeostatic process involved in the maintenance of a steady state level of water within a cell." [GOC:dph, GOC:tb] synonym: "cellular osmoregulation" RELATED [GOC:dph, GOC:tb] synonym: "cellular water homeostasis" EXACT [] is_a: GO:0006884 ! cell volume homeostasis is_a: GO:0055082 ! intracellular chemical homeostasis intersection_of: GO:0019725 ! cellular homeostasis intersection_of: RO:0002332 CHEBI:15377 ! regulates levels of relationship: RO:0002332 CHEBI:15377 ! regulates levels of [Term] id: GO:0009994 name: oocyte differentiation namespace: biological_process def: "The process in which a relatively unspecialized immature germ cell acquires the specialized features of a mature female gamete." [GOC:go_curators, GOC:mtg_sensu] synonym: "oocyte cell differentiation" EXACT [] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0030154 ! cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000023 ! results in acquisition of features of oocyte relationship: BFO:0000050 GO:0048477 ! part of oogenesis relationship: RO:0002315 CL:0000023 ! results in acquisition of features of oocyte [Term] id: GO:0010001 name: glial cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires the specialized features of a glial cell." [GOC:go_curators, GOC:mtg_sensu] synonym: "glia cell differentiation" EXACT [] synonym: "neuroglia differentiation" EXACT [] is_a: GO:0030154 ! cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000125 ! results in acquisition of features of glial cell relationship: BFO:0000050 GO:0042063 ! part of gliogenesis relationship: RO:0002315 CL:0000125 ! results in acquisition of features of glial cell [Term] id: GO:0010002 name: cardioblast differentiation namespace: biological_process def: "The process in which a relatively unspecialized mesodermal cell acquires the specialized structural and/or functional features of a cardioblast. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating." [GOC:go_curators] synonym: "cardiac precursor cell differentiation" EXACT [GOC:mtg_heart] synonym: "cardioblast cell differentiation" EXACT [] synonym: "cardiomyocyte generation" RELATED [] is_a: GO:0035051 ! cardiocyte differentiation is_a: GO:0048863 ! stem cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0002664 ! results in acquisition of features of cardioblast relationship: RO:0002315 CL:0002664 ! results in acquisition of features of cardioblast [Term] id: GO:0010004 name: gastrulation involving germ band extension namespace: biological_process def: "A complex and coordinated series of cellular movements, including germ band extension, that occurs at the end of cleavage during embryonic development. An example of this process is found in Drosophila melanogaster." [GOC:go_curators, GOC:mtg_sensu] is_a: GO:0001703 ! gastrulation with mouth forming first [Term] id: GO:0010020 name: chloroplast fission namespace: biological_process def: "The division of a chloroplast within a cell to form two or more separate chloroplast compartments. This division occurs independently of mitosis." [GOC:lr] synonym: "chloroplast division" EXACT [] is_a: GO:0009658 ! chloroplast organization is_a: GO:0043572 ! plastid fission intersection_of: GO:0048285 ! organelle fission intersection_of: results_in_fission_of GO:0009507 ! chloroplast relationship: results_in_fission_of GO:0009507 ! chloroplast property_value: RO:0002161 NCBITaxon:28009 property_value: RO:0002161 NCBITaxon:33208 property_value: RO:0002161 NCBITaxon:4751 property_value: RO:0002161 NCBITaxon:554915 [Term] id: GO:0010032 name: meiotic chromosome condensation namespace: biological_process def: "Compaction of chromatin structure prior to meiosis in eukaryotic cells." [PMID:10072401] synonym: "chromosome condensation involved in meiotic cell cycle" EXACT [GOC:dph, GOC:tb] is_a: GO:0030261 ! chromosome condensation is_a: GO:0070192 ! chromosome organization involved in meiotic cell cycle intersection_of: GO:0030261 ! chromosome condensation intersection_of: BFO:0000050 GO:0051321 ! part of meiotic cell cycle [Term] id: GO:0010038 name: response to metal ion namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a metal ion stimulus." [GOC:sm] synonym: "heavy metal sensitivity/resistance" RELATED [] synonym: "response to heavy metal" NARROW [] synonym: "response to metal" EXACT [] xref: Reactome:R-HSA-5660526 "Response to metal ions" is_a: GO:0042221 ! response to chemical intersection_of: GO:0050896 ! response to stimulus intersection_of: RO:0004009 CHEBI:25213 ! has primary input relationship: RO:0004009 CHEBI:25213 ! has primary input [Term] id: GO:0010039 name: response to iron ion namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an iron ion stimulus." [GOC:sm] synonym: "response to iron" EXACT [] is_a: GO:0010038 ! response to metal ion intersection_of: GO:0050896 ! response to stimulus intersection_of: RO:0004009 CHEBI:24875 ! has primary input relationship: RO:0004009 CHEBI:24875 ! has primary input [Term] id: GO:0010070 name: zygote asymmetric cell division namespace: biological_process def: "The division of the zygote into two daughter cells that will adopt developmentally distinct potentials." [GOC:tb] synonym: "zygote asymmetric cytokinesis" RELATED [] is_a: BFO:0000003 is_a: GO:0008356 ! asymmetric cell division intersection_of: GO:0008356 ! asymmetric cell division intersection_of: RO:0004009 CL:0000365 ! has primary input animal zygote relationship: RO:0004009 CL:0000365 ! has primary input animal zygote [Term] id: GO:0010109 name: regulation of photosynthesis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of photosynthesis." [GOC:sm] is_a: GO:0019222 ! regulation of metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0015979 ! regulates photosynthesis relationship: RO:0002211 GO:0015979 ! regulates photosynthesis property_value: RO:0002161 NCBITaxon:33208 property_value: RO:0002161 NCBITaxon:4895 [Term] id: GO:0010155 name: regulation of proton transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of proton transport into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:sm] is_a: GO:1904062 ! regulation of monoatomic cation transmembrane transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:1902600 ! regulates proton transmembrane transport relationship: RO:0002211 GO:1902600 ! regulates proton transmembrane transport [Term] id: GO:0010160 name: formation of animal organ boundary namespace: biological_process def: "The regionalization process that specifies animal organ primordium boundaries resulting in a restriction of organogenesis to a limited spatial domain and keeping the organ separate from surrounding tissues." [GOC:dph, GOC:isa_complete, PMID:9611175] synonym: "organ boundary specification" EXACT [] is_a: GO:0003002 ! regionalization is_a: GO:0048859 ! formation of anatomical boundary intersection_of: GO:0048859 ! formation of anatomical boundary intersection_of: BFO:0000066 UBERON:0000062 ! occurs in organ relationship: BFO:0000050 GO:0048645 ! part of animal organ formation relationship: BFO:0000066 UBERON:0000062 ! occurs in organ [Term] id: GO:0010171 name: body morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the soma are generated and organized." [GOC:ems, ISBN:0140512888] is_a: BFO:0000003 is_a: GO:0009653 ! anatomical structure morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0000468 ! results in morphogenesis of multicellular organism relationship: RO:0002298 UBERON:0000468 ! results in morphogenesis of multicellular organism [Term] id: GO:0010232 name: vascular transport namespace: biological_process def: "The directed movement of substances, into, out of or within a cell, either in a vascular tissue or in the vascular membrane." [GOC:sm] is_a: GO:0003018 ! vascular process in circulatory system is_a: GO:0006810 ! transport property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0010256 name: endomembrane system organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the endomembrane system." [GOC:mah, GOC:sm] subset: goslim_drosophila synonym: "endomembrane organization" EXACT [] synonym: "endomembrane system organisation" EXACT [GOC:mah] is_a: GO:0016043 ! cellular component organization intersection_of: GO:0016043 ! cellular component organization intersection_of: RO:0002592 GO:0012505 ! results in organization of endomembrane system relationship: RO:0002592 GO:0012505 ! results in organization of endomembrane system [Term] id: GO:0010324 name: membrane invagination namespace: biological_process def: "The infolding of a membrane." [GOC:tb] subset: goslim_yeast synonym: "single-organism membrane invagination" RELATED [] is_a: GO:0061024 ! membrane organization creation_date: 2013-12-02T13:58:34Z [Term] id: GO:0010453 name: regulation of cell fate commitment namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cell fate commitment. Cell fate commitment is the commitment of cells to specific cell fates and their capacity to differentiate into particular kinds of cells. Positional information is established through protein signals that emanate from a localized source within a cell (the initial one-cell zygote) or within a developmental field." [GOC:dph, GOC:tb] is_a: GO:0050793 ! regulation of developmental process is_a: GO:0050794 ! regulation of cellular process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0045165 ! regulates cell fate commitment relationship: RO:0002211 GO:0045165 ! regulates cell fate commitment [Term] id: GO:0010454 name: negative regulation of cell fate commitment namespace: biological_process def: "Any process that stops, prevents or reduces the frequency or rate of cell fate commitment. Cell fate commitment is the commitment of cells to specific cell fates and their capacity to differentiate into particular kinds of cells. Positional information is established through protein signals that emanate from a localized source within a cell (the initial one-cell zygote) or within a developmental field." [GOC:dph, GOC:tb] is_a: GO:0010453 ! regulation of cell fate commitment is_a: GO:0045596 ! negative regulation of cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0045165 ! negatively regulates cell fate commitment relationship: RO:0002212 GO:0045165 ! negatively regulates cell fate commitment [Term] id: GO:0010455 name: positive regulation of cell fate commitment namespace: biological_process def: "Any process that activates, maintains or increases the frequency or rate of cell fate commitment. Cell fate commitment is the commitment of cells to specific cell fates and their capacity to differentiate into particular kinds of cells. Positional information is established through protein signals that emanate from a localized source within a cell (the initial one-cell zygote) or within a developmental field." [GOC:dph, GOC:tb] is_a: GO:0010453 ! regulation of cell fate commitment is_a: GO:0045597 ! positive regulation of cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0045165 ! positively regulates cell fate commitment relationship: RO:0002213 GO:0045165 ! positively regulates cell fate commitment [Term] id: GO:0010456 name: cell proliferation in dorsal spinal cord namespace: biological_process def: "The multiplication or reproduction of cells, resulting in the expansion of the dorsal spinal cord cell population." [GOC:dph, GOC:tb] is_a: BFO:0000003 is_a: GO:0061351 ! neural precursor cell proliferation intersection_of: GO:0008283 ! cell population proliferation intersection_of: BFO:0000066 UBERON:0002256 ! occurs in dorsal horn of spinal cord relationship: BFO:0000066 UBERON:0002256 ! occurs in dorsal horn of spinal cord property_value: RO:0002161 NCBITaxon:4751 [Term] id: GO:0010463 name: mesenchymal cell proliferation namespace: biological_process def: "The multiplication or reproduction of cells, resulting in the expansion of a mesenchymal cell population. A mesenchymal cell is a cell that normally gives rise to other cells that are organized as three-dimensional masses, rather than sheets." [GOC:dph, GOC:tb] is_a: BFO:0000003 is_a: GO:0008283 ! cell population proliferation intersection_of: GO:0008283 ! cell population proliferation intersection_of: RO:0012003 CL:0008019 ! acts on population of mesenchymal cell relationship: RO:0012003 CL:0008019 ! acts on population of mesenchymal cell property_value: RO:0002161 NCBITaxon:4751 [Term] id: GO:0010464 name: regulation of mesenchymal cell proliferation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of mesenchymal cell proliferation. A mesenchymal cell is a cell that normally gives rise to other cells that are organized as three-dimensional masses, rather than sheets." [GOC:dph, GOC:tb] is_a: GO:0042127 ! regulation of cell population proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0010463 ! regulates mesenchymal cell proliferation relationship: RO:0002211 GO:0010463 ! regulates mesenchymal cell proliferation property_value: RO:0002161 NCBITaxon:4751 [Term] id: GO:0010467 name: gene expression namespace: biological_process def: "The process in which a gene's sequence is converted into a mature gene product (protein or RNA). This includes the production of an RNA transcript and its processing, as well as translation and maturation for protein-coding genes." [GOC:txnOH-2018, PMID:25934543, PMID:31580950] subset: goslim_flybase_ribbon xref: Wikipedia:Gene_expression is_a: GO:0009059 ! macromolecule biosynthetic process property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/22557" xsd:anyURI property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/25419" xsd:anyURI [Term] id: GO:0010468 name: regulation of gene expression namespace: biological_process def: "Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA)." [GOC:txnOH-2018] comment: This class covers any process that regulates the rate of production of a mature gene product, and so includes processes that regulate that rate by regulating the level, stability or availability of intermediates in the process of gene expression. For example, it covers any process that regulates the level, stability or availability of mRNA or circRNA for translation and thereby regulates the rate of production of the encoded protein via translation. subset: goslim_euk_cellular_processes_ribbon subset: goslim_plant_ribbon synonym: "gene regulation" RELATED [GOC:cjm] synonym: "regulation of gene product expression" RELATED [] synonym: "regulation of protein expression" NARROW [] xref: Reactome:R-HSA-163767 "PP2A-mediated dephosphorylation of key metabolic factors" xref: Reactome:R-HSA-9752946 "Expression and translocation of olfactory receptors" xref: Wikipedia:Regulation_of_gene_expression is_a: GO:0010556 ! regulation of macromolecule biosynthetic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0010467 ! regulates gene expression relationship: RO:0002211 GO:0010467 ! regulates gene expression property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/22557" xsd:anyURI [Term] id: GO:0010469 name: regulation of signaling receptor activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of a signaling receptor activity. Receptor activity is when a molecule combines with an extracellular or intracellular messenger to initiate a change in cell activity." [GOC:dph, GOC:tb] subset: gocheck_obsoletion_candidate synonym: "regulation of receptor activity" BROAD [] synonym: "regulation of signalling receptor activity" EXACT [] is_a: GO:0009966 ! regulation of signal transduction is_a: GO:0065009 ! regulation of molecular function intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0038023 ! regulates signaling receptor activity relationship: RO:0002211 GO:0038023 ! regulates signaling receptor activity [Term] id: GO:0010470 name: regulation of gastrulation namespace: biological_process def: "Any process that modulates the rate or extent of gastrulation. Gastrulation is the complex and coordinated series of cellular movements that occurs at the end of cleavage during embryonic development of most animals." [GOC:dph, GOC:tb] is_a: GO:0022603 ! regulation of anatomical structure morphogenesis is_a: GO:0045995 ! regulation of embryonic development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0007369 ! regulates gastrulation relationship: RO:0002211 GO:0007369 ! regulates gastrulation [Term] id: GO:0010481 name: epidermal cell division namespace: biological_process def: "Any process resulting in the physical partitioning and separation of an epidermal cell, any of the cells making up the epidermis, into daughter cells." [PMID:17450124] synonym: "hypodermal cell division" RELATED [GOC:kmv, GOC:rk] is_a: BFO:0000003 is_a: GO:0051301 ! cell division intersection_of: GO:0051301 ! cell division intersection_of: RO:0004009 CL:0000362 ! has primary input epidermal cell relationship: RO:0004009 CL:0000362 ! has primary input epidermal cell [Term] id: GO:0010482 name: regulation of epidermal cell division namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the physical partitioning and separation of an epidermal cell into daughter cells. An epidermal cell is any of the cells that make up the epidermis." [PMID:17450124] synonym: "regulation of hypodermal cell division" RELATED [GOC:kmv, GOC:rk] is_a: GO:0051302 ! regulation of cell division intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0010481 ! regulates epidermal cell division relationship: RO:0002211 GO:0010481 ! regulates epidermal cell division [Term] id: GO:0010496 name: intercellular transport namespace: biological_process def: "The movement of substances between cells." [GOC:dhl] synonym: "single organism intercellular transport" RELATED [GOC:TermGenie] synonym: "single-organism intercellular transport" RELATED [] is_a: BFO:0000003 is_a: GO:0006810 ! transport is_a: GO:0009987 ! cellular process intersection_of: GO:0006810 ! transport intersection_of: RO:0002338 CL:0000000 ! has target start location cell intersection_of: RO:0002339 CL:0000000 ! has target end location cell intersection_of: RO:0002342 GO:0005615 ! results in transport across extracellular space relationship: RO:0002338 CL:0000000 ! has target start location cell relationship: RO:0002339 CL:0000000 ! has target end location cell relationship: RO:0002342 GO:0005615 ! results in transport across extracellular space creation_date: 2013-12-19T13:24:56Z [Term] id: GO:0010543 name: regulation of platelet activation namespace: biological_process def: "Any process that modulates the rate or frequency of platelet activation. Platelet activation is a series of progressive, overlapping events triggered by exposure of the platelets to subendothelial tissue." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0050865 ! regulation of cell activation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0030168 ! regulates platelet activation relationship: RO:0002211 GO:0030168 ! regulates platelet activation [Term] id: GO:0010544 name: negative regulation of platelet activation namespace: biological_process def: "Any process that decreases the rate or frequency of platelet activation. Platelet activation is a series of progressive, overlapping events triggered by exposure of the platelets to subendothelial tissue." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0010543 ! regulation of platelet activation is_a: GO:0030195 ! negative regulation of blood coagulation is_a: GO:0050866 ! negative regulation of cell activation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0030168 ! negatively regulates platelet activation relationship: RO:0002212 GO:0030168 ! negatively regulates platelet activation [Term] id: GO:0010549 name: regulation of membrane disassembly namespace: biological_process def: "Any process that modulates the frequency, rate or extent of membrane disassembly." [GOC:dph, GOC:tb] is_a: GO:0051128 ! regulation of cellular component organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0030397 ! regulates membrane disassembly relationship: RO:0002211 GO:0030397 ! regulates membrane disassembly [Term] id: GO:0010556 name: regulation of macromolecule biosynthetic process namespace: biological_process def: "Any process that modulates the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:dph, GOC:tb] is_a: GO:0009889 ! regulation of biosynthetic process is_a: GO:0060255 ! regulation of macromolecule metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0009059 ! regulates macromolecule biosynthetic process relationship: RO:0002211 GO:0009059 ! regulates macromolecule biosynthetic process [Term] id: GO:0010557 name: positive regulation of macromolecule biosynthetic process namespace: biological_process def: "Any process that increases the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:dph, GOC:tb] is_a: GO:0009891 ! positive regulation of biosynthetic process is_a: GO:0010556 ! regulation of macromolecule biosynthetic process is_a: GO:0010604 ! positive regulation of macromolecule metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0009059 ! positively regulates macromolecule biosynthetic process relationship: RO:0002213 GO:0009059 ! positively regulates macromolecule biosynthetic process [Term] id: GO:0010558 name: negative regulation of macromolecule biosynthetic process namespace: biological_process def: "Any process that decreases the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:dph, GOC:tb] subset: gocheck_do_not_annotate is_a: GO:0009890 ! negative regulation of biosynthetic process is_a: GO:0010556 ! regulation of macromolecule biosynthetic process is_a: GO:0010605 ! negative regulation of macromolecule metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0009059 ! negatively regulates macromolecule biosynthetic process relationship: RO:0002212 GO:0009059 ! negatively regulates macromolecule biosynthetic process property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/30771" xsd:anyURI [Term] id: GO:0010559 name: regulation of glycoprotein biosynthetic process namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of the chemical reactions and pathways resulting in the formation of a glycoprotein, a protein that contains covalently bound glycose (i.e. monosaccharide) residues; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide." [GOC:dph, GOC:tb] is_a: GO:0010556 ! regulation of macromolecule biosynthetic process is_a: GO:1903018 ! regulation of glycoprotein metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0009101 ! regulates glycoprotein biosynthetic process relationship: RO:0002211 GO:0009101 ! regulates glycoprotein biosynthetic process [Term] id: GO:0010560 name: positive regulation of glycoprotein biosynthetic process namespace: biological_process def: "Any process that increases the rate, frequency, or extent of the chemical reactions and pathways resulting in the formation of a glycoprotein, a protein that contains covalently bound glycose (i.e. monosaccharide) residues; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide." [GOC:dph, GOC:tb] is_a: GO:0010557 ! positive regulation of macromolecule biosynthetic process is_a: GO:0010559 ! regulation of glycoprotein biosynthetic process is_a: GO:1903020 ! positive regulation of glycoprotein metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0009101 ! positively regulates glycoprotein biosynthetic process relationship: RO:0002213 GO:0009101 ! positively regulates glycoprotein biosynthetic process [Term] id: GO:0010561 name: negative regulation of glycoprotein biosynthetic process namespace: biological_process def: "Any process that decreases the rate, frequency, or extent of the chemical reactions and pathways resulting in the formation of a glycoprotein, a protein that contains covalently bound glycose (i.e. monosaccharide) residues; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide." [GOC:dph, GOC:tb] is_a: GO:0010558 ! negative regulation of macromolecule biosynthetic process is_a: GO:0010559 ! regulation of glycoprotein biosynthetic process is_a: GO:1903019 ! negative regulation of glycoprotein metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0009101 ! negatively regulates glycoprotein biosynthetic process relationship: RO:0002212 GO:0009101 ! negatively regulates glycoprotein biosynthetic process [Term] id: GO:0010562 name: positive regulation of phosphorus metabolic process namespace: biological_process def: "Any process that increases the frequency, rate or extent of the chemical reactions and pathways involving phosphorus or compounds containing phosphorus." [GOC:dph, GOC:tb] is_a: GO:0009893 ! positive regulation of metabolic process is_a: GO:0051174 ! regulation of phosphorus metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0006793 ! positively regulates phosphorus metabolic process relationship: RO:0002213 GO:0006793 ! positively regulates phosphorus metabolic process [Term] id: GO:0010563 name: negative regulation of phosphorus metabolic process namespace: biological_process def: "Any process that decreases the frequency, rate or extent of the chemical reactions and pathways involving phosphorus or compounds containing phosphorus." [GOC:dph, GOC:tb] is_a: GO:0009892 ! negative regulation of metabolic process is_a: GO:0051174 ! regulation of phosphorus metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0006793 ! negatively regulates phosphorus metabolic process relationship: RO:0002212 GO:0006793 ! negatively regulates phosphorus metabolic process [Term] id: GO:0010564 name: regulation of cell cycle process namespace: biological_process def: "Any process that modulates a cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events." [GOC:dph, GOC:tb] is_a: GO:0051726 ! regulation of cell cycle intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0022402 ! regulates cell cycle process relationship: RO:0002211 GO:0022402 ! regulates cell cycle process [Term] id: GO:0010565 name: regulation of ketone metabolic process namespace: biological_process def: "Any process that modulates the chemical reactions and pathways involving any of a class of organic compounds that contain the carbonyl group, CO, and in which the carbonyl group is bonded only to carbon atoms. The general formula for a ketone is RCOR, where R and R are alkyl or aryl groups." [GOC:dph, GOC:tb] is_a: GO:0019222 ! regulation of metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0042180 ! regulates ketone metabolic process relationship: RO:0002211 GO:0042180 ! regulates ketone metabolic process property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/28908" xsd:anyURI [Term] id: GO:0010566 name: regulation of ketone biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of a ketone, carried out by individual cells." [GOC:dph, GOC:tb] is_a: GO:0009889 ! regulation of biosynthetic process is_a: GO:0010565 ! regulation of ketone metabolic process is_a: GO:0062012 ! regulation of small molecule metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0042181 ! regulates ketone biosynthetic process relationship: RO:0002211 GO:0042181 ! regulates ketone biosynthetic process [Term] id: GO:0010567 name: regulation of ketone catabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a ketone, carried out by individual cells." [GOC:dph, GOC:tb] is_a: GO:0009894 ! regulation of catabolic process is_a: GO:0010565 ! regulation of ketone metabolic process is_a: GO:0062012 ! regulation of small molecule metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0042182 ! regulates ketone catabolic process relationship: RO:0002211 GO:0042182 ! regulates ketone catabolic process [Term] id: GO:0010572 name: positive regulation of platelet activation namespace: biological_process def: "Any process that increases the rate or frequency of platelet activation. Platelet activation is a series of progressive, overlapping events triggered by exposure of the platelets to subendothelial tissue." [GOC:dph, GOC:sl, GOC:tb] is_a: GO:0010543 ! regulation of platelet activation is_a: GO:0050867 ! positive regulation of cell activation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0030168 ! positively regulates platelet activation relationship: RO:0002213 GO:0030168 ! positively regulates platelet activation [Term] id: GO:0010581 name: regulation of starch biosynthetic process namespace: biological_process def: "An process which modulate the frequency, rate or extent of starch biosynthesis, the chemical reactions and pathways resulting in the formation of starch." [GOC:tb] is_a: GO:0010962 ! regulation of glucan biosynthetic process is_a: GO:2000904 ! regulation of starch metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0019252 ! regulates starch biosynthetic process relationship: RO:0002211 GO:0019252 ! regulates starch biosynthetic process [Term] id: GO:0010594 name: regulation of endothelial cell migration namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of the orderly movement of an endothelial cell into the extracellular matrix to form an endothelium." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0030334 ! regulation of cell migration intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0043542 ! regulates endothelial cell migration relationship: RO:0002211 GO:0043542 ! regulates endothelial cell migration property_value: RO:0002161 NCBITaxon:451864 [Term] id: GO:0010595 name: positive regulation of endothelial cell migration namespace: biological_process def: "Any process that increases the rate, frequency, or extent of the orderly movement of an endothelial cell into the extracellular matrix to form an endothelium." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0010594 ! regulation of endothelial cell migration is_a: GO:0030335 ! positive regulation of cell migration intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0043542 ! positively regulates endothelial cell migration relationship: RO:0002213 GO:0043542 ! positively regulates endothelial cell migration property_value: RO:0002161 NCBITaxon:451864 [Term] id: GO:0010596 name: negative regulation of endothelial cell migration namespace: biological_process def: "Any process that decreases the rate, frequency, or extent of the orderly movement of an endothelial cell into the extracellular matrix to form an endothelium." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0010594 ! regulation of endothelial cell migration is_a: GO:0030336 ! negative regulation of cell migration intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0043542 ! negatively regulates endothelial cell migration relationship: RO:0002212 GO:0043542 ! negatively regulates endothelial cell migration property_value: RO:0002161 NCBITaxon:451864 [Term] id: GO:0010604 name: positive regulation of macromolecule metabolic process namespace: biological_process def: "Any process that increases the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:dph, GOC:tb] is_a: GO:0009893 ! positive regulation of metabolic process is_a: GO:0060255 ! regulation of macromolecule metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0043170 ! positively regulates macromolecule metabolic process relationship: RO:0002213 GO:0043170 ! positively regulates macromolecule metabolic process [Term] id: GO:0010605 name: negative regulation of macromolecule metabolic process namespace: biological_process def: "Any process that decreases the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:dph, GOC:tb] is_a: GO:0009892 ! negative regulation of metabolic process is_a: GO:0060255 ! regulation of macromolecule metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0043170 ! negatively regulates macromolecule metabolic process relationship: RO:0002212 GO:0043170 ! negatively regulates macromolecule metabolic process [Term] id: GO:0010608 name: post-transcriptional regulation of gene expression namespace: biological_process def: "Any process that modulates the frequency, rate or extent of gene expression after the production of an RNA transcript." [GOC:dph, GOC:tb] synonym: "posttranscriptional regulation of gene expression" EXACT [] is_a: GO:0010468 ! regulation of gene expression [Term] id: GO:0010611 name: regulation of cardiac muscle hypertrophy namespace: biological_process def: "Any process that modulates the rate, frequency or extent of the enlargement or overgrowth of all or part of the heart due to an increase in size (not length) of individual cardiac muscle fibers, without cell division." [GOC:dph, GOC:tb] is_a: GO:0014743 ! regulation of muscle hypertrophy is_a: GO:0043502 ! regulation of muscle adaptation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0003300 ! regulates cardiac muscle hypertrophy relationship: RO:0002211 GO:0003300 ! regulates cardiac muscle hypertrophy property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0010612 name: regulation of cardiac muscle adaptation namespace: biological_process def: "Any process that modulates the rate, extent or frequency of the process in which cardiac muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors." [GOC:dph, GOC:tb] is_a: GO:0043502 ! regulation of muscle adaptation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0014887 ! regulates cardiac muscle adaptation relationship: RO:0002211 GO:0014887 ! regulates cardiac muscle adaptation property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0010613 name: positive regulation of cardiac muscle hypertrophy namespace: biological_process def: "Any process that increases the rate, frequency or extent of the enlargement or overgrowth of all or part of the heart due to an increase in size (not length) of individual cardiac muscle fibers, without cell division." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0010611 ! regulation of cardiac muscle hypertrophy is_a: GO:0014742 ! positive regulation of muscle hypertrophy intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0003300 ! positively regulates cardiac muscle hypertrophy relationship: RO:0002213 GO:0003300 ! positively regulates cardiac muscle hypertrophy property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0010614 name: negative regulation of cardiac muscle hypertrophy namespace: biological_process def: "Any process that decreases the rate, frequency or extent of the enlargement or overgrowth of all or part of the heart due to an increase in size (not length) of individual cardiac muscle fibers, without cell division." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0010611 ! regulation of cardiac muscle hypertrophy is_a: GO:0014741 ! negative regulation of muscle hypertrophy intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0003300 ! negatively regulates cardiac muscle hypertrophy relationship: RO:0002212 GO:0003300 ! negatively regulates cardiac muscle hypertrophy property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0010615 name: positive regulation of cardiac muscle adaptation namespace: biological_process def: "Any process that increases the rate, extent or frequency of the process in which cardiac muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0010612 ! regulation of cardiac muscle adaptation is_a: GO:0014744 ! positive regulation of muscle adaptation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0014887 ! positively regulates cardiac muscle adaptation relationship: RO:0002213 GO:0014887 ! positively regulates cardiac muscle adaptation property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0010616 name: negative regulation of cardiac muscle adaptation namespace: biological_process def: "Any process that decreases the rate, extent or frequency of the process in which cardiac muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0010612 ! regulation of cardiac muscle adaptation is_a: GO:0014745 ! negative regulation of muscle adaptation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0014887 ! negatively regulates cardiac muscle adaptation relationship: RO:0002212 GO:0014887 ! negatively regulates cardiac muscle adaptation property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0010623 name: programmed cell death involved in cell development namespace: biological_process def: "The activation of endogenous cellular processes that result in the death of a cell as part of its development." [GOC:dph, GOC:mtg_apoptosis, GOC:tb] comment: This process is part of the natural developmental program of some cell types, but it does not always happen as part of the development or shaping of a gross anatomical structure. synonym: "developmental programmed cell death" BROAD [] synonym: "programmed cell death involved in development" BROAD [] is_a: GO:0012501 ! programmed cell death is_a: GO:0048869 ! cellular developmental process intersection_of: GO:0012501 ! programmed cell death intersection_of: BFO:0000050 GO:0048468 ! part of cell development relationship: BFO:0000050 GO:0048468 ! part of cell development [Term] id: GO:0010624 name: regulation of Schwann cell proliferation namespace: biological_process def: "Any process that modulates the frequency or rate of multiplication or reproduction of Schwann cells, resulting in the expansion of their population. Schwann cells are a type of glial cell in the peripheral nervous system." [GOC:dph, GOC:sl, GOC:tb] is_a: GO:0060251 ! regulation of glial cell proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0014010 ! regulates Schwann cell proliferation relationship: RO:0002211 GO:0014010 ! regulates Schwann cell proliferation [Term] id: GO:0010625 name: positive regulation of Schwann cell proliferation namespace: biological_process def: "Any process that increases the frequency or rate of the multiplication or reproduction of Schwann cells, resulting in the expansion of their population. Schwann cells are a type of glial cell in the peripheral nervous system." [GOC:dph, GOC:sl, GOC:tb] is_a: GO:0010624 ! regulation of Schwann cell proliferation is_a: GO:0060252 ! positive regulation of glial cell proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0014010 ! positively regulates Schwann cell proliferation relationship: RO:0002213 GO:0014010 ! positively regulates Schwann cell proliferation [Term] id: GO:0010626 name: negative regulation of Schwann cell proliferation namespace: biological_process def: "Any process that decreases the frequency or extent of the multiplication or reproduction of Schwann cells, resulting in the expansion of their population. Schwann cells are a type of glial cell in the peripheral nervous system." [GOC:dph, GOC:sl, GOC:tb] is_a: GO:0010624 ! regulation of Schwann cell proliferation is_a: GO:0060253 ! negative regulation of glial cell proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0014010 ! negatively regulates Schwann cell proliferation relationship: RO:0002212 GO:0014010 ! negatively regulates Schwann cell proliferation [Term] id: GO:0010628 name: positive regulation of gene expression namespace: biological_process def: "Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA)." [GOC:txnOH-2018] is_a: GO:0010468 ! regulation of gene expression is_a: GO:0010557 ! positive regulation of macromolecule biosynthetic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0010467 ! positively regulates gene expression relationship: RO:0002213 GO:0010467 ! positively regulates gene expression property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/22557" xsd:anyURI [Term] id: GO:0010629 name: negative regulation of gene expression namespace: biological_process def: "Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA)." [GOC:txnOH-2018] comment: This term covers any process that negatively regulates the rate of production of a mature gene product, and so includes processes that negatively regulate that rate by reducing the level, stability or availability of intermediates in the process of gene expression. For example, it covers any process that reduces the level, stability or availability of mRNA or circRNA for translation and thereby reduces the rate of production of the encoded protein via translation. synonym: "gene silencing" RELATED [] is_a: GO:0010468 ! regulation of gene expression is_a: GO:0010558 ! negative regulation of macromolecule biosynthetic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0010467 ! negatively regulates gene expression relationship: RO:0002212 GO:0010467 ! negatively regulates gene expression property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/22557" xsd:anyURI [Term] id: GO:0010631 name: epithelial cell migration namespace: biological_process def: "The orderly movement of an epithelial cell from one site to another, often during the development of a multicellular organism." [GOC:ascb_2009, GOC:BHF, GOC:dph, GOC:tb] is_a: BFO:0000003 is_a: GO:0001667 ! ameboidal-type cell migration intersection_of: GO:0016477 ! cell migration intersection_of: RO:0002565 CL:0000066 ! results in movement of epithelial cell relationship: BFO:0000050 GO:0090132 ! part of epithelium migration relationship: RO:0002565 CL:0000066 ! results in movement of epithelial cell property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4890 [Term] id: GO:0010632 name: regulation of epithelial cell migration namespace: biological_process def: "Any process that modulates the frequency, rate or extent of epithelial cell migration." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0030334 ! regulation of cell migration is_a: GO:0051239 ! regulation of multicellular organismal process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0010631 ! regulates epithelial cell migration relationship: RO:0002211 GO:0010631 ! regulates epithelial cell migration property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:451864 [Term] id: GO:0010633 name: negative regulation of epithelial cell migration namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of epithelial cell migration." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0010632 ! regulation of epithelial cell migration is_a: GO:0030336 ! negative regulation of cell migration is_a: GO:0051241 ! negative regulation of multicellular organismal process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0010631 ! negatively regulates epithelial cell migration relationship: RO:0002212 GO:0010631 ! negatively regulates epithelial cell migration property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:451864 [Term] id: GO:0010634 name: positive regulation of epithelial cell migration namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of epithelial cell migration." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0010632 ! regulation of epithelial cell migration is_a: GO:0030335 ! positive regulation of cell migration intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0010631 ! positively regulates epithelial cell migration relationship: RO:0002213 GO:0010631 ! positively regulates epithelial cell migration property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:451864 [Term] id: GO:0010635 name: regulation of mitochondrial fusion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of merging of two or more mitochondria within a cell to form a single compartment." [GOC:dph, GOC:tb] is_a: GO:0010821 ! regulation of mitochondrion organization is_a: GO:0022603 ! regulation of anatomical structure morphogenesis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0008053 ! regulates mitochondrial fusion relationship: RO:0002211 GO:0008053 ! regulates mitochondrial fusion [Term] id: GO:0010636 name: positive regulation of mitochondrial fusion namespace: biological_process def: "Any process that increases the frequency, rate or extent of merging of two or more mitochondria within a cell to form a single compartment." [GOC:dph, GOC:tb] is_a: GO:0010635 ! regulation of mitochondrial fusion is_a: GO:0010638 ! positive regulation of organelle organization is_a: GO:0051094 ! positive regulation of developmental process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0008053 ! positively regulates mitochondrial fusion relationship: RO:0002213 GO:0008053 ! positively regulates mitochondrial fusion [Term] id: GO:0010637 name: negative regulation of mitochondrial fusion namespace: biological_process def: "Any process that decreases the frequency, rate or extent of merging of two or more mitochondria within a cell to form a single compartment." [GOC:dph, GOC:tb] is_a: GO:0010635 ! regulation of mitochondrial fusion is_a: GO:0010639 ! negative regulation of organelle organization is_a: GO:0051093 ! negative regulation of developmental process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0008053 ! negatively regulates mitochondrial fusion relationship: RO:0002212 GO:0008053 ! negatively regulates mitochondrial fusion [Term] id: GO:0010638 name: positive regulation of organelle organization namespace: biological_process def: "Any process that increases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of an organelle." [GOC:dph, GOC:tb] subset: gocheck_do_not_annotate synonym: "positive regulation of organelle organisation" EXACT [GOC:mah] synonym: "positive regulation of organelle organization and biogenesis" RELATED [GOC:mah] is_a: GO:0033043 ! regulation of organelle organization is_a: GO:0051130 ! positive regulation of cellular component organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0006996 ! positively regulates organelle organization relationship: RO:0002213 GO:0006996 ! positively regulates organelle organization [Term] id: GO:0010639 name: negative regulation of organelle organization namespace: biological_process def: "Any process that decreases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of an organelle." [GOC:dph, GOC:tb] subset: gocheck_do_not_annotate synonym: "negative regulation of organelle organisation" EXACT [GOC:mah] synonym: "negative regulation of organelle organization and biogenesis" RELATED [GOC:mah] is_a: GO:0033043 ! regulation of organelle organization is_a: GO:0051129 ! negative regulation of cellular component organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0006996 ! negatively regulates organelle organization relationship: RO:0002212 GO:0006996 ! negatively regulates organelle organization [Term] id: GO:0010646 name: regulation of cell communication namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cell communication. Cell communication is the process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment." [GOC:dph, GOC:tb] is_a: GO:0050794 ! regulation of cellular process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0007154 ! regulates cell communication relationship: RO:0002211 GO:0007154 ! regulates cell communication [Term] id: GO:0010647 name: positive regulation of cell communication namespace: biological_process def: "Any process that increases the frequency, rate or extent of cell communication. Cell communication is the process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment." [GOC:dph, GOC:tb] is_a: GO:0010646 ! regulation of cell communication is_a: GO:0048522 ! positive regulation of cellular process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0007154 ! positively regulates cell communication relationship: RO:0002213 GO:0007154 ! positively regulates cell communication [Term] id: GO:0010648 name: negative regulation of cell communication namespace: biological_process def: "Any process that decreases the frequency, rate or extent of cell communication. Cell communication is the process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment." [GOC:dph, GOC:tb] is_a: GO:0010646 ! regulation of cell communication is_a: GO:0048523 ! negative regulation of cellular process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0007154 ! negatively regulates cell communication relationship: RO:0002212 GO:0007154 ! negatively regulates cell communication [Term] id: GO:0010656 name: negative regulation of muscle cell apoptotic process namespace: biological_process def: "Any process that decreases the rate or frequency of muscle cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a muscle cell and result in its death." [GOC:dph, GOC:mtg_apoptosis, GOC:tb] synonym: "negative regulation of muscle cell apoptosis" NARROW [] is_a: GO:0010660 ! regulation of muscle cell apoptotic process is_a: GO:0043066 ! negative regulation of apoptotic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0010657 ! negatively regulates muscle cell apoptotic process relationship: RO:0002212 GO:0010657 ! negatively regulates muscle cell apoptotic process [Term] id: GO:0010657 name: muscle cell apoptotic process namespace: biological_process def: "A form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases, whose actions dismantle a muscle cell and result in its death. A muscle cell is a mature contractile cell, commonly known as a myocyte, that forms one of three kinds of muscle." [CL:0000187, GOC:dph, GOC:mtg_apoptosis, GOC:tb] synonym: "muscle cell apoptosis" NARROW [] is_a: GO:0006915 ! apoptotic process intersection_of: GO:0006915 ! apoptotic process intersection_of: BFO:0000066 CL:0000187 ! occurs in muscle cell relationship: BFO:0000066 CL:0000187 ! occurs in muscle cell relationship: RO:0002162 NCBITaxon:33208 ! in taxon Metazoa [Term] id: GO:0010658 name: striated muscle cell apoptotic process namespace: biological_process def: "A form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases, whose actions dismantle a striated muscle cell and result in its death. Striated muscle cells make up striated muscle fibers which are divided by transverse bands into striations." [CL:0000737, GOC:dph, GOC:mtg_apoptosis, GOC:tb] synonym: "striated muscle cell apoptosis" NARROW [] is_a: GO:0010657 ! muscle cell apoptotic process intersection_of: GO:0006915 ! apoptotic process intersection_of: BFO:0000066 CL:0000737 ! occurs in striated muscle cell relationship: BFO:0000066 CL:0000737 ! occurs in striated muscle cell [Term] id: GO:0010659 name: cardiac muscle cell apoptotic process namespace: biological_process def: "A form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases, whose actions dismantle a cardiac muscle cell and result in its death. Cardiac muscle cells are striated muscle cells that are responsible for heart contraction." [CL:0000746, GOC:dph, GOC:mtg_apoptosis, GOC:tb] synonym: "cardiac muscle cell apoptosis" NARROW [] is_a: GO:0010658 ! striated muscle cell apoptotic process intersection_of: GO:0006915 ! apoptotic process intersection_of: BFO:0000066 CL:0000746 ! occurs in cardiac muscle cell relationship: BFO:0000066 CL:0000746 ! occurs in cardiac muscle cell [Term] id: GO:0010660 name: regulation of muscle cell apoptotic process namespace: biological_process def: "Any process that modulates the rate or frequency of muscle cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a muscle cell and result in its death." [GOC:dph, GOC:mtg_apoptosis, GOC:tb] synonym: "regulation of muscle cell apoptosis" NARROW [] is_a: GO:0042981 ! regulation of apoptotic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0010657 ! regulates muscle cell apoptotic process relationship: RO:0002211 GO:0010657 ! regulates muscle cell apoptotic process [Term] id: GO:0010661 name: positive regulation of muscle cell apoptotic process namespace: biological_process def: "Any process that increases the rate or frequency of muscle cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a muscle cell and result in its death." [GOC:dph, GOC:mtg_apoptosis, GOC:tb] synonym: "positive regulation of muscle cell apoptosis" NARROW [] is_a: GO:0010660 ! regulation of muscle cell apoptotic process is_a: GO:0043065 ! positive regulation of apoptotic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0010657 ! positively regulates muscle cell apoptotic process relationship: RO:0002213 GO:0010657 ! positively regulates muscle cell apoptotic process [Term] id: GO:0010662 name: regulation of striated muscle cell apoptotic process namespace: biological_process def: "Any process that modulates the rate or extent of striated muscle cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a striated muscle cell and result in its death." [GOC:dph, GOC:mtg_apoptosis, GOC:tb] synonym: "regulation of striated muscle cell apoptosis" NARROW [] is_a: GO:0010660 ! regulation of muscle cell apoptotic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0010658 ! regulates striated muscle cell apoptotic process relationship: RO:0002211 GO:0010658 ! regulates striated muscle cell apoptotic process [Term] id: GO:0010663 name: positive regulation of striated muscle cell apoptotic process namespace: biological_process def: "Any process that increases the rate or extent of striated muscle cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a striated muscle cell and result in its death." [GOC:dph, GOC:mtg_apoptosis, GOC:tb] synonym: "positive regulation of striated muscle cell apoptosis" NARROW [] is_a: GO:0010661 ! positive regulation of muscle cell apoptotic process is_a: GO:0010662 ! regulation of striated muscle cell apoptotic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0010658 ! positively regulates striated muscle cell apoptotic process relationship: RO:0002213 GO:0010658 ! positively regulates striated muscle cell apoptotic process [Term] id: GO:0010664 name: negative regulation of striated muscle cell apoptotic process namespace: biological_process def: "Any process that decreases the rate or extent of striated muscle cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a striated muscle cell and result in its death." [GOC:BHF, GOC:dph, GOC:mtg_apoptosis, GOC:rl, GOC:tb] synonym: "down regulation of striated muscle cell apoptosis" EXACT [GOC:dph, GOC:rl, GOC:tb] synonym: "down-regulation of striated muscle cell apoptosis" EXACT [GOC:dph, GOC:rl, GOC:tb] synonym: "downregulation of striated muscle cell apoptosis" EXACT [GOC:dph, GOC:rl, GOC:tb] synonym: "inhibition of striated muscle cell apoptosis" NARROW [GOC:dph, GOC:rl, GOC:tb] synonym: "negative regulation of striated muscle cell apoptosis" NARROW [] is_a: GO:0010656 ! negative regulation of muscle cell apoptotic process is_a: GO:0010662 ! regulation of striated muscle cell apoptotic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0010658 ! negatively regulates striated muscle cell apoptotic process relationship: RO:0002212 GO:0010658 ! negatively regulates striated muscle cell apoptotic process [Term] id: GO:0010665 name: regulation of cardiac muscle cell apoptotic process namespace: biological_process def: "Any process that modulates the rate or extent of cardiac cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a cardiac muscle cell and result in its death." [GOC:dph, GOC:mtg_apoptosis, GOC:tb] synonym: "regulation of cardiac muscle cell apoptosis" NARROW [] is_a: GO:0010662 ! regulation of striated muscle cell apoptotic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0010659 ! regulates cardiac muscle cell apoptotic process relationship: RO:0002211 GO:0010659 ! regulates cardiac muscle cell apoptotic process [Term] id: GO:0010666 name: positive regulation of cardiac muscle cell apoptotic process namespace: biological_process def: "Any process that increases the rate or extent of cardiac cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a cardiac muscle cell and result in its death." [GOC:dph, GOC:mtg_apoptosis, GOC:tb] synonym: "positive regulation of cardiac muscle cell apoptosis" NARROW [] is_a: GO:0010663 ! positive regulation of striated muscle cell apoptotic process is_a: GO:0010665 ! regulation of cardiac muscle cell apoptotic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0010659 ! positively regulates cardiac muscle cell apoptotic process relationship: RO:0002213 GO:0010659 ! positively regulates cardiac muscle cell apoptotic process [Term] id: GO:0010667 name: negative regulation of cardiac muscle cell apoptotic process namespace: biological_process def: "Any process that decreases the rate or extent of cardiac cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a cardiac muscle cell and result in its death." [GOC:BHF, GOC:dph, GOC:mtg_apoptosis, GOC:rl, GOC:tb] synonym: "down regulation of cardiac muscle cell apoptosis" EXACT [GOC:dph, GOC:rl, GOC:tb] synonym: "down-regulation of cardiac muscle cell apoptosis" EXACT [GOC:dph, GOC:rl, GOC:tb] synonym: "downregulation of cardiac muscle cell apoptosis" EXACT [GOC:dph, GOC:rl, GOC:tb] synonym: "inhibition of cardiac muscle cell apoptosis" NARROW [GOC:dph, GOC:rl, GOC:tb] synonym: "negative regulation of cardiac muscle cell apoptosis" NARROW [] is_a: GO:0010664 ! negative regulation of striated muscle cell apoptotic process is_a: GO:0010665 ! regulation of cardiac muscle cell apoptotic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0010659 ! negatively regulates cardiac muscle cell apoptotic process relationship: RO:0002212 GO:0010659 ! negatively regulates cardiac muscle cell apoptotic process [Term] id: GO:0010668 name: ectodermal cell differentiation namespace: biological_process def: "The process in which relatively unspecialized cells acquire specialized structural and/or functional features of an ectodermal cell. Differentiation includes the processes involved in commitment of a cell to a specific fate." [GOC:dph, GOC:tb] is_a: GO:0030154 ! cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000221 ! results in acquisition of features of ectodermal cell relationship: BFO:0000050 GO:0007398 ! part of ectoderm development relationship: RO:0002315 CL:0000221 ! results in acquisition of features of ectodermal cell [Term] id: GO:0010700 name: negative regulation of norepinephrine secretion namespace: biological_process def: "Any process that decreases the frequency, rate or extent of the regulated release of norepinephrine." [GOC:dph, GOC:tb] is_a: GO:0014061 ! regulation of norepinephrine secretion is_a: GO:0033604 ! negative regulation of catecholamine secretion intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0048243 ! negatively regulates norepinephrine secretion relationship: RO:0002212 GO:0048243 ! negatively regulates norepinephrine secretion [Term] id: GO:0010701 name: positive regulation of norepinephrine secretion namespace: biological_process def: "Any process that increases the frequency, rate or extent of the regulated release of norepinephrine." [GOC:dph, GOC:tb] is_a: GO:0014061 ! regulation of norepinephrine secretion is_a: GO:0033605 ! positive regulation of catecholamine secretion intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0048243 ! positively regulates norepinephrine secretion relationship: RO:0002213 GO:0048243 ! positively regulates norepinephrine secretion [Term] id: GO:0010710 name: regulation of collagen catabolic process namespace: biological_process def: "Any process that modulates the rate, frequency or extent of collagen catabolism. Collagen catabolism is the proteolytic chemical reactions and pathways resulting in the breakdown of collagen in the extracellular matrix." [GOC:BHF, GOC:dph, GOC:tb] synonym: "regulation of collagen breakdown" EXACT [GOC:dph, GOC:tb] synonym: "regulation of collagen catabolism" EXACT [GOC:dph, GOC:tb] synonym: "regulation of collagen degradation" EXACT [GOC:dph, GOC:tb] is_a: GO:0009894 ! regulation of catabolic process is_a: GO:0010712 ! regulation of collagen metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0030574 ! regulates collagen catabolic process relationship: RO:0002211 GO:0030574 ! regulates collagen catabolic process [Term] id: GO:0010711 name: negative regulation of collagen catabolic process namespace: biological_process def: "Any process that decreases the rate, frequency or extent of collagen catabolism. Collagen catabolism is the proteolytic chemical reactions and pathways resulting in the breakdown of collagen in the extracellular matrix." [GOC:BHF, GOC:dph, GOC:tb] synonym: "down regulation of collagen catabolic process" EXACT [GOC:dph, GOC:tb] synonym: "down-regulation of collagen catabolic process" EXACT [GOC:dph, GOC:tb] synonym: "downregulation of collagen catabolic process" EXACT [GOC:dph, GOC:tb] synonym: "inhibition of collagen catabolic process" NARROW [GOC:dph, GOC:tb] synonym: "negative regulation of collagen breakdown" EXACT [GOC:dph, GOC:tb] synonym: "negative regulation of collagen catabolism" EXACT [GOC:dph, GOC:tb] synonym: "negative regulation of collagen degradation" EXACT [GOC:dph, GOC:tb] is_a: GO:0009895 ! negative regulation of catabolic process is_a: GO:0010710 ! regulation of collagen catabolic process is_a: GO:0010713 ! negative regulation of collagen metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0030574 ! negatively regulates collagen catabolic process relationship: RO:0002212 GO:0030574 ! negatively regulates collagen catabolic process [Term] id: GO:0010712 name: regulation of collagen metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the metabolism of collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals." [GOC:dph, GOC:tb] synonym: "regulation of collagen metabolism" EXACT [GOC:dph, GOC:tb] is_a: GO:0019222 ! regulation of metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0032963 ! regulates collagen metabolic process relationship: RO:0002211 GO:0032963 ! regulates collagen metabolic process [Term] id: GO:0010713 name: negative regulation of collagen metabolic process namespace: biological_process def: "Any process that decreases the frequency, rate or extent of the chemical reactions and pathways resulting in the metabolism of collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals." [GOC:dph, GOC:tb] is_a: GO:0009892 ! negative regulation of metabolic process is_a: GO:0010712 ! regulation of collagen metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0032963 ! negatively regulates collagen metabolic process relationship: RO:0002212 GO:0032963 ! negatively regulates collagen metabolic process [Term] id: GO:0010714 name: positive regulation of collagen metabolic process namespace: biological_process def: "Any process that increases the frequency, rate or extent of the chemical reactions and pathways resulting in the metabolism of collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals." [GOC:dph, GOC:tb] synonym: "positive regulation of collagen metabolism" EXACT [GOC:dph, GOC:tb] is_a: GO:0009893 ! positive regulation of metabolic process is_a: GO:0010712 ! regulation of collagen metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0032963 ! positively regulates collagen metabolic process relationship: RO:0002213 GO:0032963 ! positively regulates collagen metabolic process [Term] id: GO:0010715 name: regulation of extracellular matrix disassembly namespace: biological_process def: "Any process that modulates the rate, frequency or extent of extracellular matrix disassembly. Extracellular matrix disassembly is a process that results in the breakdown of the extracellular matrix." [GOC:BHF, GOC:dph, GOC:tb] synonym: "regulation of extracellular matrix breakdown" EXACT [GOC:dph, GOC:tb] synonym: "regulation of extracellular matrix degradation" EXACT [GOC:dph, GOC:tb] is_a: GO:1903053 ! regulation of extracellular matrix organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0022617 ! regulates extracellular matrix disassembly relationship: RO:0002211 GO:0022617 ! regulates extracellular matrix disassembly [Term] id: GO:0010716 name: negative regulation of extracellular matrix disassembly namespace: biological_process def: "Any process that decreases the rate, frequency or extent of extracellular matrix disassembly. Extracellular matrix disassembly is a process that results in the breakdown of the extracellular matrix." [GOC:BHF, GOC:dph, GOC:tb] synonym: "down regulation of extracellular matrix disassembly" EXACT [GOC:dph, GOC:tb] synonym: "down-regulation of extracellular matrix disassembly" EXACT [GOC:dph, GOC:tb] synonym: "downregulation of extracellular matrix disassembly" EXACT [GOC:dph, GOC:tb] synonym: "inhibition of extracellular matrix disassembly" NARROW [GOC:dph, GOC:tb] synonym: "negative regulation of extracellular matrix breakdown" EXACT [GOC:dph, GOC:tb] synonym: "negative regulation of extracellular matrix degradation" EXACT [GOC:dph, GOC:tb] is_a: GO:0010715 ! regulation of extracellular matrix disassembly is_a: GO:1903054 ! negative regulation of extracellular matrix organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0022617 ! negatively regulates extracellular matrix disassembly relationship: RO:0002212 GO:0022617 ! negatively regulates extracellular matrix disassembly [Term] id: GO:0010717 name: regulation of epithelial to mesenchymal transition namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of epithelial to mesenchymal transition. Epithelial to mesenchymal transition where an epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0045595 ! regulation of cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0001837 ! regulates epithelial to mesenchymal transition relationship: RO:0002211 GO:0001837 ! regulates epithelial to mesenchymal transition [Term] id: GO:0010718 name: positive regulation of epithelial to mesenchymal transition namespace: biological_process def: "Any process that increases the rate, frequency, or extent of epithelial to mesenchymal transition. Epithelial to mesenchymal transition is where an epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0010717 ! regulation of epithelial to mesenchymal transition is_a: GO:0045597 ! positive regulation of cell differentiation is_a: GO:0051240 ! positive regulation of multicellular organismal process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0001837 ! positively regulates epithelial to mesenchymal transition relationship: RO:0002213 GO:0001837 ! positively regulates epithelial to mesenchymal transition [Term] id: GO:0010719 name: negative regulation of epithelial to mesenchymal transition namespace: biological_process def: "Any process that decreases the rate, frequency, or extent of epithelial to mesenchymal transition. Epithelial to mesenchymal transition where an epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0010717 ! regulation of epithelial to mesenchymal transition is_a: GO:0045596 ! negative regulation of cell differentiation is_a: GO:0051241 ! negative regulation of multicellular organismal process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0001837 ! negatively regulates epithelial to mesenchymal transition relationship: RO:0002212 GO:0001837 ! negatively regulates epithelial to mesenchymal transition [Term] id: GO:0010720 name: positive regulation of cell development namespace: biological_process def: "Any process that increases the rate, frequency or extent of the progression of the cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0045597 ! positive regulation of cell differentiation is_a: GO:0060284 ! regulation of cell development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0048468 ! positively regulates cell development relationship: RO:0002213 GO:0048468 ! positively regulates cell development [Term] id: GO:0010721 name: negative regulation of cell development namespace: biological_process def: "Any process that decreases the rate, frequency or extent of the progression of the cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0045596 ! negative regulation of cell differentiation is_a: GO:0060284 ! regulation of cell development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0048468 ! negatively regulates cell development relationship: RO:0002212 GO:0048468 ! negatively regulates cell development [Term] id: GO:0010725 name: regulation of primitive erythrocyte differentiation namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of primitive erythrocyte differentiation. Primitive erythrocyte differentiation occurs as part of the process of primitive hemopoiesis." [GOC:add, GOC:dph, GOC:tb] synonym: "regulation of primitive erythropoeisis" EXACT [GOC:add, GOC:dph, GOC:tb] synonym: "regulation of primitive RBC differentiation" EXACT [CL:0000232] synonym: "regulation of primitive red blood cell differentiation" EXACT [CL:0000232] is_a: GO:0045646 ! regulation of erythrocyte differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0060319 ! regulates primitive erythrocyte differentiation relationship: RO:0002211 GO:0060319 ! regulates primitive erythrocyte differentiation [Term] id: GO:0010742 name: macrophage derived foam cell differentiation namespace: biological_process def: "The process in which a monocyte acquires the specialized features of a foam cell. A foam cell is a type of cell containing lipids in small vacuoles and typically seen in atherosclerotic lesions, as well as other conditions." [GOC:add, GOC:dph, GOC:tb] is_a: GO:0090077 ! foam cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000517 ! results in acquisition of features of macrophage derived foam cell relationship: RO:0002315 CL:0000517 ! results in acquisition of features of macrophage derived foam cell [Term] id: GO:0010743 name: regulation of macrophage derived foam cell differentiation namespace: biological_process def: "Any process that modulates the rate, frequency or extent of macrophage derived foam cell differentiation. Macrophage derived foam cell differentiation is the process in which a macrophage acquires the specialized features of a foam cell. A foam cell is a type of cell containing lipids in small vacuoles and typically seen in atherosclerotic lesions, as well as other conditions." [GOC:add, GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0045595 ! regulation of cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0010742 ! regulates macrophage derived foam cell differentiation relationship: RO:0002211 GO:0010742 ! regulates macrophage derived foam cell differentiation [Term] id: GO:0010744 name: positive regulation of macrophage derived foam cell differentiation namespace: biological_process def: "Any process that increases the rate, frequency or extent of macrophage derived foam cell differentiation. Macrophage derived foam cell differentiation is the process in which a macrophage acquires the specialized features of a foam cell. A foam cell is a type of cell containing lipids in small vacuoles and typically seen in atherosclerotic lesions, as well as other conditions." [GOC:add, GOC:dph, GOC:tb] is_a: GO:0010743 ! regulation of macrophage derived foam cell differentiation is_a: GO:0045597 ! positive regulation of cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0010742 ! positively regulates macrophage derived foam cell differentiation relationship: RO:0002213 GO:0010742 ! positively regulates macrophage derived foam cell differentiation [Term] id: GO:0010745 name: negative regulation of macrophage derived foam cell differentiation namespace: biological_process def: "Any process that decreases the rate, frequency or extent of macrophage derived foam cell differentiation. Macrophage derived foam cell differentiation is the process in which a macrophage acquires the specialized features of a foam cell. A foam cell is a type of cell containing lipids in small vacuoles and typically seen in atherosclerotic lesions, as well as other conditions." [GOC:add, GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0010743 ! regulation of macrophage derived foam cell differentiation is_a: GO:0045596 ! negative regulation of cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0010742 ! negatively regulates macrophage derived foam cell differentiation relationship: RO:0002212 GO:0010742 ! negatively regulates macrophage derived foam cell differentiation [Term] id: GO:0010758 name: regulation of macrophage chemotaxis namespace: biological_process def: "Any process that modulates the rate, frequency or extent of macrophage chemotaxis. Macrophage chemotaxis is the movement of a macrophage in response to an external stimulus." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0002688 ! regulation of leukocyte chemotaxis is_a: GO:1905521 ! regulation of macrophage migration intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0048246 ! regulates macrophage chemotaxis relationship: RO:0002211 GO:0048246 ! regulates macrophage chemotaxis [Term] id: GO:0010759 name: positive regulation of macrophage chemotaxis namespace: biological_process def: "Any process that increases the rate, frequency or extent of macrophage chemotaxis. Macrophage chemotaxis is the movement of a macrophage in response to an external stimulus." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0002690 ! positive regulation of leukocyte chemotaxis is_a: GO:0010758 ! regulation of macrophage chemotaxis is_a: GO:0071622 ! regulation of granulocyte chemotaxis is_a: GO:1905523 ! positive regulation of macrophage migration intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0048246 ! positively regulates macrophage chemotaxis relationship: RO:0002213 GO:0048246 ! positively regulates macrophage chemotaxis [Term] id: GO:0010760 name: negative regulation of macrophage chemotaxis namespace: biological_process def: "Any process that decreases the rate, frequency or extent of macrophage chemotaxis. Macrophage chemotaxis is the movement of a macrophage in response to an external stimulus." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0002689 ! negative regulation of leukocyte chemotaxis is_a: GO:0010758 ! regulation of macrophage chemotaxis is_a: GO:1905522 ! negative regulation of macrophage migration intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0048246 ! negatively regulates macrophage chemotaxis relationship: RO:0002212 GO:0048246 ! negatively regulates macrophage chemotaxis [Term] id: GO:0010761 name: fibroblast migration namespace: biological_process def: "Cell migration that is accomplished by extension and retraction of a fibroblast pseudopodium. A fibroblast is a connective tissue cell which secretes an extracellular matrix rich in collagen and other macromolecules." [GOC:BHF, GOC:dph, GOC:tb] synonym: "fibroblast cell migration" EXACT [GOC:dph] is_a: BFO:0000003 is_a: GO:0001667 ! ameboidal-type cell migration intersection_of: GO:0016477 ! cell migration intersection_of: RO:0002565 CL:0000057 ! results in movement of fibroblast relationship: RO:0002565 CL:0000057 ! results in movement of fibroblast property_value: RO:0002161 NCBITaxon:4890 [Term] id: GO:0010762 name: regulation of fibroblast migration namespace: biological_process def: "Any process that modulates the rate, frequency or extent of fibroblast cell migration. Fibroblast cell migration is accomplished by extension and retraction of a pseudopodium." [GOC:dph, GOC:tb] synonym: "regulation of fibroblast cell migration" EXACT [GOC:dph] is_a: GO:0030334 ! regulation of cell migration intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0010761 ! regulates fibroblast migration relationship: RO:0002211 GO:0010761 ! regulates fibroblast migration property_value: RO:0002161 NCBITaxon:451864 [Term] id: GO:0010763 name: positive regulation of fibroblast migration namespace: biological_process def: "Any process that increases the rate, frequency or extent of fibroblast cell migration. Fibroblast cell migration is accomplished by extension and retraction of a pseudopodium." [GOC:BHF, GOC:dph, GOC:tb] synonym: "positive regulation of fibroblast cell migration" EXACT [GOC:dph] is_a: GO:0010762 ! regulation of fibroblast migration is_a: GO:0030335 ! positive regulation of cell migration intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0010761 ! positively regulates fibroblast migration relationship: RO:0002213 GO:0010761 ! positively regulates fibroblast migration property_value: RO:0002161 NCBITaxon:451864 [Term] id: GO:0010764 name: negative regulation of fibroblast migration namespace: biological_process def: "Any process that decreases the rate, frequency or extent of fibroblast cell migration. Fibroblast cell migration is accomplished by extension and retraction of a pseudopodium." [GOC:dph, GOC:tb] synonym: "negative regulation of fibroblast cell migration" EXACT [GOC:dph] is_a: GO:0010762 ! regulation of fibroblast migration is_a: GO:0030336 ! negative regulation of cell migration intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0010761 ! negatively regulates fibroblast migration relationship: RO:0002212 GO:0010761 ! negatively regulates fibroblast migration property_value: RO:0002161 NCBITaxon:451864 [Term] id: GO:0010765 name: positive regulation of sodium ion transport namespace: biological_process def: "Any process that increases the frequency, rate or extent of the directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:dph, GOC:tb] is_a: GO:0002028 ! regulation of sodium ion transport is_a: GO:0043270 ! positive regulation of monoatomic ion transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0006814 ! positively regulates sodium ion transport relationship: RO:0002213 GO:0006814 ! positively regulates sodium ion transport [Term] id: GO:0010766 name: negative regulation of sodium ion transport namespace: biological_process def: "Any process that decreases the frequency, rate or extent of the directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:dph, GOC:tb] is_a: GO:0002028 ! regulation of sodium ion transport is_a: GO:0043271 ! negative regulation of monoatomic ion transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0006814 ! negatively regulates sodium ion transport relationship: RO:0002212 GO:0006814 ! negatively regulates sodium ion transport [Term] id: GO:0010770 name: positive regulation of cell morphogenesis namespace: biological_process def: "Any process that increases the frequency, rate or extent of cell morphogenesis contributing to cell differentiation. Cell morphogenesis involved in differentiation is the change in form (cell shape and size) that occurs when relatively unspecialized cells acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history." [GOC:dph, GOC:tb] is_a: GO:0010720 ! positive regulation of cell development is_a: GO:0022604 ! regulation of cell morphogenesis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0000902 ! positively regulates cell morphogenesis relationship: RO:0002213 GO:0000902 ! positively regulates cell morphogenesis property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/24299" xsd:anyURI [Term] id: GO:0010771 name: negative regulation of cell morphogenesis namespace: biological_process def: "Any process that decreases the frequency, rate or extent of cell morphogenesis contributing to cell differentiation. Cell morphogenesis involved in differentiation is the change in form (cell shape and size) that occurs when relatively unspecialized cells acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history." [GOC:dph, GOC:tb] is_a: GO:0010721 ! negative regulation of cell development is_a: GO:0022604 ! regulation of cell morphogenesis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0000902 ! negatively regulates cell morphogenesis relationship: RO:0002212 GO:0000902 ! negatively regulates cell morphogenesis property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/24299" xsd:anyURI [Term] id: GO:0010816 name: calcitonin catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of the peptide calcitonin." [GOC:BHF, GOC:rl] is_a: GO:0042447 ! hormone catabolic process is_a: GO:0043603 ! amide metabolic process intersection_of: GO:0009056 ! catabolic process intersection_of: RO:0004009 CHEBI:3306 ! has primary input relationship: RO:0004009 CHEBI:3306 ! has primary input property_value: RO:0002161 NCBITaxon:4895 [Term] id: GO:0010817 name: regulation of hormone levels namespace: biological_process def: "Any process that modulates the levels of hormone within an organism or a tissue. A hormone is any substance formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells in the same organism, upon which it has a specific regulatory action." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0065008 ! regulation of biological quality [Term] id: GO:0010818 name: T cell chemotaxis namespace: biological_process def: "The directed movement of a T cell in response to an external stimulus. A T cell is a type of lymphocyte whose defining characteristic is the expression of a T cell receptor complex." [GOC:dph, GOC:tb] synonym: "T-cell chemotaxis" EXACT [CL:0000084] is_a: GO:0048247 ! lymphocyte chemotaxis is_a: GO:0072678 ! T cell migration intersection_of: GO:0006935 ! chemotaxis intersection_of: RO:0002565 CL:0000084 ! results in movement of T cell [Term] id: GO:0010819 name: regulation of T cell chemotaxis namespace: biological_process def: "Any process that modulates the rate, frequency or extent of T cell chemotaxis. T cell chemotaxis is the directed movement of a T cell in response to an external stimulus." [GOC:dph, GOC:tb] is_a: GO:1901623 ! regulation of lymphocyte chemotaxis is_a: GO:2000404 ! regulation of T cell migration intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0010818 ! regulates T cell chemotaxis relationship: RO:0002211 GO:0010818 ! regulates T cell chemotaxis [Term] id: GO:0010820 name: positive regulation of T cell chemotaxis namespace: biological_process def: "Any process that increases the rate, frequency or extent of T cell chemotaxis. T cell chemotaxis is the directed movement of a T cell in response to an external stimulus." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0010819 ! regulation of T cell chemotaxis is_a: GO:0140131 ! positive regulation of lymphocyte chemotaxis is_a: GO:2000406 ! positive regulation of T cell migration intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0010818 ! positively regulates T cell chemotaxis relationship: RO:0002213 GO:0010818 ! positively regulates T cell chemotaxis [Term] id: GO:0010821 name: regulation of mitochondrion organization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a mitochondrion." [GOC:dph, GOC:tb] synonym: "regulation of mitochondrion organisation" EXACT [GOC:mah] is_a: GO:0033043 ! regulation of organelle organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0007005 ! regulates mitochondrion organization relationship: RO:0002211 GO:0007005 ! regulates mitochondrion organization [Term] id: GO:0010827 name: regulation of D-glucose transmembrane transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of glucose transport across a membrane. Glucose transport is the directed movement of the hexose monosaccharide glucose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:dph, GOC:tb] synonym: "regulation of glucose transmembrane transport" EXACT [] synonym: "regulation of glucose transport" RELATED [] is_a: GO:0034762 ! regulation of transmembrane transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:1904659 ! regulates D-glucose transmembrane transport relationship: RO:0002211 GO:1904659 ! regulates D-glucose transmembrane transport [Term] id: GO:0010828 name: positive regulation of D-glucose transmembrane transport namespace: biological_process def: "Any process that increases the frequency, rate or extent of glucose transport across a membrane. Glucose transport is the directed movement of the hexose monosaccharide glucose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:BHF, GOC:dph, GOC:tb] synonym: "positive regulation of glucose transmembrane transport" EXACT [] synonym: "positive regulation of glucose transport" RELATED [] is_a: GO:0010827 ! regulation of D-glucose transmembrane transport is_a: GO:0034764 ! positive regulation of transmembrane transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:1904659 ! positively regulates D-glucose transmembrane transport relationship: RO:0002213 GO:1904659 ! positively regulates D-glucose transmembrane transport [Term] id: GO:0010829 name: negative regulation of D-glucose transmembrane transport namespace: biological_process def: "Any process that decreases the frequency, rate or extent of glucose transport across a membrane. Glucose transport is the directed movement of the hexose monosaccharide glucose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:BHF, GOC:dph, GOC:tb] synonym: "negative regulation of glucose transmembrane transport" EXACT [] synonym: "negative regulation of glucose transport" RELATED [] is_a: GO:0010827 ! regulation of D-glucose transmembrane transport is_a: GO:0034763 ! negative regulation of transmembrane transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:1904659 ! negatively regulates D-glucose transmembrane transport relationship: RO:0002212 GO:1904659 ! negatively regulates D-glucose transmembrane transport [Term] id: GO:0010830 name: regulation of myotube differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of myotube differentiation. Myotube differentiation is the process in which a relatively unspecialized cell acquires specialized features of a myotube cell. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate and fuse." [GOC:dph, GOC:tb] is_a: GO:0051153 ! regulation of striated muscle cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0014902 ! regulates myotube differentiation relationship: RO:0002211 GO:0014902 ! regulates myotube differentiation [Term] id: GO:0010831 name: positive regulation of myotube differentiation namespace: biological_process def: "Any process that activates, maintains or increases the frequency, rate or extent of myotube differentiation. Myotube differentiation is the process in which a relatively unspecialized cell acquires specialized features of a myotube cell. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate and fuse." [GOC:dph, GOC:tb] is_a: GO:0010830 ! regulation of myotube differentiation is_a: GO:0051155 ! positive regulation of striated muscle cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0014902 ! positively regulates myotube differentiation relationship: RO:0002213 GO:0014902 ! positively regulates myotube differentiation [Term] id: GO:0010832 name: negative regulation of myotube differentiation namespace: biological_process def: "Any process that decreases the frequency, rate or extent of myotube differentiation. Myotube differentiation is the process in which a relatively unspecialized cell acquires specialized features of a myotube cell. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate and fuse." [GOC:dph, GOC:tb] is_a: GO:0010830 ! regulation of myotube differentiation is_a: GO:0051154 ! negative regulation of striated muscle cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0014902 ! negatively regulates myotube differentiation relationship: RO:0002212 GO:0014902 ! negatively regulates myotube differentiation [Term] id: GO:0010837 name: regulation of keratinocyte proliferation namespace: biological_process def: "Any process that modulates the rate, frequency or extent of keratinocyte proliferation. Keratinocyte proliferation is the multiplication or reproduction of keratinocytes, resulting in the expansion of a cell population." [GOC:dph, GOC:tb] is_a: GO:0050678 ! regulation of epithelial cell proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0043616 ! regulates keratinocyte proliferation relationship: RO:0002211 GO:0043616 ! regulates keratinocyte proliferation property_value: RO:0002161 NCBITaxon:4751 property_value: RO:0002161 NCBITaxon:6656 [Term] id: GO:0010838 name: positive regulation of keratinocyte proliferation namespace: biological_process def: "Any process that increases the rate, frequency or extent of keratinocyte proliferation. Keratinocyte proliferation is the multiplication or reproduction of keratinocytes, resulting in the expansion of a cell population." [GOC:dph, GOC:tb] is_a: GO:0010837 ! regulation of keratinocyte proliferation is_a: GO:0050679 ! positive regulation of epithelial cell proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0043616 ! positively regulates keratinocyte proliferation relationship: RO:0002213 GO:0043616 ! positively regulates keratinocyte proliferation property_value: RO:0002161 NCBITaxon:4751 property_value: RO:0002161 NCBITaxon:6656 [Term] id: GO:0010839 name: negative regulation of keratinocyte proliferation namespace: biological_process def: "Any process that decreases the rate, frequency or extent of keratinocyte proliferation. Keratinocyte proliferation is the multiplication or reproduction of keratinocytes, resulting in the expansion of a cell population." [GOC:dph, GOC:tb] is_a: GO:0010837 ! regulation of keratinocyte proliferation is_a: GO:0050680 ! negative regulation of epithelial cell proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0043616 ! negatively regulates keratinocyte proliferation relationship: RO:0002212 GO:0043616 ! negatively regulates keratinocyte proliferation property_value: RO:0002161 NCBITaxon:4751 property_value: RO:0002161 NCBITaxon:6656 [Term] id: GO:0010842 name: retina layer formation namespace: biological_process def: "The process in which the vertebrate retina is organized into three laminae: the outer nuclear layer (ONL), which contains photoreceptor nuclei; the inner nuclear layer (INL), which contains amacrine, bipolar and horizontal cells; and the retinal ganglion cell (RGC) layer. Between the inner and outer nuclear layers, the outer plexiform layer (OPL) contains connections between the photoreceptors and bipolar and horizontal cells. The inner plexiform layer (IPL) is positioned between the INL and the ganglion cell layer and contains the dendrites of RGCs and processes of bipolar and amacrine cells. Spanning all layers of the retina are the radially oriented Mueller glia." [GOC:ascb_2009, GOC:dph, GOC:tb, PMID:1270266] synonym: "retinal lamination" EXACT [GOC:dph, GOC:tb] synonym: "retinal layer formation" EXACT [GOC:dph, GOC:tb] is_a: BFO:0000003 is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0001781 ! results in formation of anatomical entity layer of retina relationship: BFO:0000050 GO:0003407 ! part of neural retina development relationship: BFO:0000050 GO:0060042 ! part of retina morphogenesis in camera-type eye relationship: RO:0002297 UBERON:0001781 ! results in formation of anatomical entity layer of retina [Term] id: GO:0010876 name: lipid localization namespace: biological_process def: "Any process in which a lipid is transported to, or maintained in, a specific location." [GOC:BHF, GOC:dph, GOC:tb] synonym: "lipid localisation" EXACT [GOC:mah] is_a: BFO:0000003 is_a: GO:0033036 ! macromolecule localization intersection_of: GO:0033036 ! macromolecule localization intersection_of: RO:0004009 CHEBI:18059 ! has primary input relationship: RO:0004009 CHEBI:18059 ! has primary input [Term] id: GO:0010882 name: regulation of cardiac muscle contraction by calcium ion signaling namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cardiac muscle contraction by changing the calcium ion signals that trigger contraction." [GOC:BHF, GOC:dph, GOC:tb] synonym: "regulation of cardiac muscle contraction by calcium ion signalling" EXACT [GOC:mah] is_a: GO:0019722 ! calcium-mediated signaling is_a: GO:0055117 ! regulation of cardiac muscle contraction intersection_of: GO:0019722 ! calcium-mediated signaling intersection_of: RO:0002211 GO:0060048 ! regulates cardiac muscle contraction property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0010892 name: positive regulation of mitochondrial translation in response to stress namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of mitochondrial translation as a result of a stimulus indicating the organism is under stress." [GOC:dph, GOC:jp, GOC:tb, PMID:8830768] is_a: GO:0032056 ! positive regulation of translation in response to stress is_a: GO:0070131 ! positive regulation of mitochondrial translation intersection_of: GO:0065007 ! biological regulation intersection_of: BFO:0000050 GO:0033554 ! part of cellular response to stress intersection_of: RO:0002213 GO:0032543 ! positively regulates mitochondrial translation [Term] id: GO:0010893 name: positive regulation of steroid biosynthetic process namespace: biological_process def: "Any process that increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus." [GOC:tb] is_a: GO:0045940 ! positive regulation of steroid metabolic process is_a: GO:0046889 ! positive regulation of lipid biosynthetic process is_a: GO:0050810 ! regulation of steroid biosynthetic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0006694 ! positively regulates steroid biosynthetic process relationship: RO:0002213 GO:0006694 ! positively regulates steroid biosynthetic process [Term] id: GO:0010894 name: negative regulation of steroid biosynthetic process namespace: biological_process def: "Any process that decreases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus." [GOC:BHF, GOC:tb] is_a: GO:0045939 ! negative regulation of steroid metabolic process is_a: GO:0050810 ! regulation of steroid biosynthetic process is_a: GO:0051055 ! negative regulation of lipid biosynthetic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0006694 ! negatively regulates steroid biosynthetic process relationship: RO:0002212 GO:0006694 ! negatively regulates steroid biosynthetic process [Term] id: GO:0010906 name: regulation of glucose metabolic process namespace: biological_process def: "Any process that modulates the rate, frequency or extent of glucose metabolism. Glucose metabolic processes are the chemical reactions and pathways involving glucose, the aldohexose gluco-hexose." [GOC:BHF, GOC:tb] synonym: "regulation of glucose metabolism" EXACT [GOC:tb] is_a: GO:0006109 ! regulation of carbohydrate metabolic process is_a: GO:0062012 ! regulation of small molecule metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0006006 ! regulates glucose metabolic process relationship: RO:0002211 GO:0006006 ! regulates glucose metabolic process [Term] id: GO:0010907 name: positive regulation of glucose metabolic process namespace: biological_process def: "Any process that increases the rate, frequency or extent of glucose metabolism. Glucose metabolic processes are the chemical reactions and pathways involving glucose, the aldohexose gluco-hexose." [GOC:BHF, GOC:tb] synonym: "positive regulation of glucose metabolism" EXACT [GOC:tb] is_a: GO:0010906 ! regulation of glucose metabolic process is_a: GO:0045913 ! positive regulation of carbohydrate metabolic process is_a: GO:0062013 ! positive regulation of small molecule metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0006006 ! positively regulates glucose metabolic process relationship: RO:0002213 GO:0006006 ! positively regulates glucose metabolic process [Term] id: GO:0010927 name: cellular component assembly involved in morphogenesis namespace: biological_process def: "The cellular component assembly that is part of the initial shaping of the component during its developmental progression." [GOC:dph, GOC:tb] is_a: GO:0022607 ! cellular component assembly is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: GO:0022607 ! cellular component assembly intersection_of: BFO:0000050 GO:0009653 ! part of anatomical structure morphogenesis relationship: BFO:0000050 GO:0032989 ! part of cellular anatomical entity morphogenesis [Term] id: GO:0010931 name: macrophage tolerance induction namespace: biological_process def: "A process involving any mechanism for tolerance induction in macrophages." [GOC:BHF, GOC:dph, GOC:tb] is_a: BFO:0000003 is_a: GO:0002507 ! tolerance induction intersection_of: GO:0002507 ! tolerance induction intersection_of: BFO:0000066 CL:0000235 ! occurs in macrophage relationship: BFO:0000066 CL:0000235 ! occurs in macrophage property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4895 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0010932 name: regulation of macrophage tolerance induction namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of macrophage tolerance induction." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0002643 ! regulation of tolerance induction intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0010931 ! regulates macrophage tolerance induction relationship: RO:0002211 GO:0010931 ! regulates macrophage tolerance induction property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4895 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0010933 name: positive regulation of macrophage tolerance induction namespace: biological_process def: "Any process that increases the frequency, rate, or extent of B cell tolerance induction." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0002645 ! positive regulation of tolerance induction is_a: GO:0010932 ! regulation of macrophage tolerance induction intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0010931 ! positively regulates macrophage tolerance induction relationship: RO:0002213 GO:0010931 ! positively regulates macrophage tolerance induction property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4895 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0010934 name: macrophage cytokine production namespace: biological_process def: "The appearance of a macrophage cytokine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:BHF, GOC:dph, GOC:rl, GOC:tb] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms. subset: gocheck_do_not_annotate is_a: GO:0061082 ! myeloid leukocyte cytokine production intersection_of: GO:0001816 ! cytokine production intersection_of: BFO:0000066 CL:0000235 ! occurs in macrophage relationship: BFO:0000066 CL:0000235 ! occurs in macrophage property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4895 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0010935 name: regulation of macrophage cytokine production namespace: biological_process def: "Any process that modulates the rate, frequency or extent of macrophage cytokine production. Macrophage cytokine production is the appearance of a chemokine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:BHF, GOC:rl] is_a: GO:0002718 ! regulation of cytokine production involved in immune response intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0010934 ! regulates macrophage cytokine production relationship: RO:0002211 GO:0010934 ! regulates macrophage cytokine production property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4895 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0010936 name: negative regulation of macrophage cytokine production namespace: biological_process def: "Any process that decreases the rate, frequency or extent of macrophage cytokine production. Macrophage cytokine production is the appearance of a chemokine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:BHF, GOC:rl] is_a: GO:0002719 ! negative regulation of cytokine production involved in immune response is_a: GO:0010935 ! regulation of macrophage cytokine production intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0010934 ! negatively regulates macrophage cytokine production relationship: RO:0002212 GO:0010934 ! negatively regulates macrophage cytokine production property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4895 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0010937 name: regulation of cytoplasmic microtubule depolymerization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cytoplasmic microtubule depolymerization." [GOC:dph, GOC:tb] is_a: GO:0031114 ! regulation of microtubule depolymerization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0010938 ! regulates cytoplasmic microtubule depolymerization relationship: RO:0002211 GO:0010938 ! regulates cytoplasmic microtubule depolymerization [Term] id: GO:0010938 name: cytoplasmic microtubule depolymerization namespace: biological_process def: "The removal of tubulin heterodimers from one or both ends of a cytoplasmic microtubule." [GOC:dph, GOC:tb] is_a: GO:0007019 ! microtubule depolymerization is_a: GO:0031122 ! cytoplasmic microtubule organization intersection_of: GO:0007019 ! microtubule depolymerization intersection_of: BFO:0000066 GO:0005737 ! occurs in cytoplasm relationship: BFO:0000066 GO:0005737 ! occurs in cytoplasm [Term] id: GO:0010948 name: negative regulation of cell cycle process namespace: biological_process def: "Any process that decreases the rate, frequency or extent of a cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events." [GOC:dph, GOC:tb] is_a: GO:0010564 ! regulation of cell cycle process is_a: GO:0045786 ! negative regulation of cell cycle intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0022402 ! negatively regulates cell cycle process relationship: RO:0002212 GO:0022402 ! negatively regulates cell cycle process creation_date: 2009-04-27T09:53:22Z [Term] id: GO:0010954 name: positive regulation of protein processing namespace: biological_process def: "Any process that increases the rate, frequency or extent of protein maturation by peptide bond cleavage." [GOC:dph, GOC:mah, GOC:tb] synonym: "positive regulation of protein maturation by peptide bond cleavage" EXACT [GOC:bf] is_a: GO:0045862 ! positive regulation of proteolysis is_a: GO:0070613 ! regulation of protein processing is_a: GO:1903319 ! positive regulation of protein maturation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0016485 ! positively regulates protein processing relationship: RO:0002213 GO:0016485 ! positively regulates protein processing creation_date: 2009-04-27T12:09:13Z [Term] id: GO:0010955 name: negative regulation of protein processing namespace: biological_process def: "Any process that decreases the rate, frequency or extent of protein maturation by peptide bond cleavage." [GOC:dph, GOC:mah, GOC:tb] synonym: "negative regulation of protein maturation by peptide bond cleavage" EXACT [GOC:bf] is_a: GO:0045861 ! negative regulation of proteolysis is_a: GO:0070613 ! regulation of protein processing is_a: GO:1903318 ! negative regulation of protein maturation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0016485 ! negatively regulates protein processing relationship: RO:0002212 GO:0016485 ! negatively regulates protein processing creation_date: 2009-04-27T12:10:19Z [Term] id: GO:0010958 name: regulation of amino acid import across plasma membrane namespace: biological_process def: "Any process that modulates the frequency, rate or extent of amino acid import into a cell." [GOC:dph, GOC:tb] synonym: "regulation of amino acid import" BROAD [] is_a: GO:1903789 ! regulation of amino acid transmembrane transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0089718 ! regulates amino acid import across plasma membrane relationship: RO:0002211 GO:0089718 ! regulates amino acid import across plasma membrane creation_date: 2009-05-06T11:33:12Z [Term] id: GO:0010959 name: regulation of metal ion transport namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of metal ion transport. Metal ion transport is the directed movement of metal ions, any metal ion with an electric charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:dph, GOC:tb] is_a: GO:0043269 ! regulation of monoatomic ion transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0030001 ! regulates metal ion transport relationship: RO:0002211 GO:0030001 ! regulates metal ion transport creation_date: 2009-05-06T11:40:55Z [Term] id: GO:0010962 name: regulation of glucan biosynthetic process namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of glucan biosynthesis. Glucan biosynthetic processes are the chemical reactions and pathways resulting in the formation of glucans, polysaccharides consisting only of glucose residues." [GOC:dph, GOC:tb] is_a: GO:0032885 ! regulation of polysaccharide biosynthetic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0009250 ! regulates glucan biosynthetic process relationship: RO:0002211 GO:0009250 ! regulates glucan biosynthetic process creation_date: 2009-05-11T12:17:53Z [Term] id: GO:0010966 name: regulation of phosphate transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of phosphate transport. Phosphate transport is the directed movement of phosphate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:dph, GOC:tb] is_a: GO:0051049 ! regulation of transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0006817 ! regulates phosphate ion transport relationship: RO:0002211 GO:0006817 ! regulates phosphate ion transport creation_date: 2009-05-20T11:42:50Z [Term] id: GO:0010968 name: regulation of microtubule nucleation namespace: biological_process def: "Any process that modulates the rate, frequency or extent of microtubule nucleation. Microtubule nucleation is the 'de novo' formation of a microtubule, in which tubulin heterodimers form metastable oligomeric aggregates, some of which go on to support formation of a complete microtubule. Microtubule nucleation usually occurs from a specific site within a cell." [GOC:dph, GOC:tb] is_a: GO:0031113 ! regulation of microtubule polymerization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0007020 ! regulates microtubule nucleation relationship: RO:0002211 GO:0007020 ! regulates microtubule nucleation creation_date: 2009-05-20T11:51:21Z [Term] id: GO:0010970 name: transport along microtubule namespace: biological_process def: "The movement of organelles or other particles from one location in the cell to another along microtubules, driven by motor activity." [GOC:dph, GOC:mah, GOC:tb] synonym: "establishment of localization by movement along microtubule" EXACT [GOC:dph] synonym: "microtubule-based transport" BROAD [] synonym: "movement along microtubule" EXACT [] is_a: GO:0007018 ! microtubule-based movement is_a: GO:0030705 ! cytoskeleton-dependent intracellular transport is_a: GO:0099111 ! microtubule-based transport intersection_of: GO:0006810 ! transport intersection_of: RO:0002341 GO:0005874 ! results in transport along microtubule relationship: RO:0002341 GO:0005874 ! results in transport along microtubule creation_date: 2009-05-27T10:56:08Z [Term] id: GO:0010975 name: regulation of neuron projection development namespace: biological_process def: "Any process that modulates the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites)." [GOC:dph, GOC:tb] synonym: "regulation of neurite biosynthesis" NARROW [GOC:mah] synonym: "regulation of neurite development" NARROW [GOC:mah] synonym: "regulation of neurite formation" NARROW [GOC:mah] synonym: "regulation of neurite growth" NARROW [GOC:mah] is_a: GO:0120035 ! regulation of plasma membrane bounded cell projection organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0031175 ! regulates neuron projection development relationship: RO:0002211 GO:0031175 ! regulates neuron projection development creation_date: 2009-06-01T10:44:45Z [Term] id: GO:0010976 name: positive regulation of neuron projection development namespace: biological_process def: "Any process that increases the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites)." [GOC:dph, GOC:tb] synonym: "positive regulation of neurite biosynthesis" NARROW [GOC:mah] synonym: "positive regulation of neurite development" NARROW [GOC:mah] synonym: "positive regulation of neurite formation" NARROW [GOC:mah] synonym: "positive regulation of neurite growth" NARROW [GOC:mah] is_a: GO:0010975 ! regulation of neuron projection development is_a: GO:0031346 ! positive regulation of cell projection organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0031175 ! positively regulates neuron projection development relationship: RO:0002213 GO:0031175 ! positively regulates neuron projection development creation_date: 2009-06-01T10:46:44Z [Term] id: GO:0010977 name: negative regulation of neuron projection development namespace: biological_process def: "Any process that decreases the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites)." [GOC:dph, GOC:tb] synonym: "growth cone collapse" RELATED [GOC:pr] synonym: "negative regulation of neurite biosynthesis" NARROW [GOC:mah] synonym: "negative regulation of neurite development" NARROW [GOC:mah] synonym: "negative regulation of neurite formation" NARROW [GOC:mah] synonym: "negative regulation of neurite growth" NARROW [GOC:mah] is_a: GO:0010975 ! regulation of neuron projection development is_a: GO:0031345 ! negative regulation of cell projection organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0031175 ! negatively regulates neuron projection development relationship: RO:0002212 GO:0031175 ! negatively regulates neuron projection development creation_date: 2009-06-01T10:47:42Z [Term] id: GO:0012501 name: programmed cell death namespace: biological_process def: "A process which begins when a cell receives an internal or external signal and activates a series of biochemical events (signaling pathway). The process ends with the death of the cell." [GOC:lr, GOC:mtg_apoptosis] comment: Note that this term should be used to annotate gene products in the organism undergoing the programmed cell death. To annotate genes in another organism whose products modulate programmed cell death in a host organism, consider the term 'modulation by symbiont of host programmed cell death ; GO:0052040'. Also, note that 'programmed cell death ; GO:0012501' should be used to refer to instances of caspase-independent cell death mechanisms, in the absence of further indications on the process taking place. At present, caspase-independent cell death is not yet represented in GO due to the lack of consensus and in-depth research on the topic. 'programmed cell death ; GO:0012501' may also be used to annotate gene products in taxa where apoptosis as defined in GO:0006915 does not occur, such as plants. You may also consider these specific children: GO:0097468 'programmed cell death in response to reactive oxygen species' (with descendants GO:0010421 'hydrogen peroxide-mediated programmed cell death' and GO:0010343 'singlet oxygen-mediated programmed cell death'), and GO:0009626 'plant-type hypersensitive response' and its children. subset: goslim_agr subset: goslim_chembl subset: goslim_drosophila subset: goslim_euk_cellular_processes_ribbon subset: goslim_generic subset: goslim_mouse subset: goslim_plant subset: goslim_plant_ribbon subset: goslim_prokaryote synonym: "caspase-independent apoptosis" RELATED [] synonym: "caspase-independent cell death" NARROW [] synonym: "non-apoptotic programmed cell death" NARROW [] synonym: "nonapoptotic programmed cell death" NARROW [] synonym: "PCD" RELATED [] synonym: "RCD" RELATED [] synonym: "regulated cell death" BROAD [] xref: Reactome:R-HSA-5357801 "Programmed Cell Death" xref: Wikipedia:Programmed_cell_death is_a: BFO:0000003 is_a: GO:0008219 ! cell death intersection_of: GO:0008219 ! cell death intersection_of: RO:0002224 GO:0007165 ! starts with signal transduction relationship: RO:0002224 GO:0007165 ! starts with signal transduction property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/24835" xsd:anyURI [Term] id: GO:0012505 name: endomembrane system namespace: cellular_component def: "A collection of membranous structures involved in transport within the cell. The main components of the endomembrane system are endoplasmic reticulum, Golgi bodies, vesicles, cell membrane and nuclear envelope. Members of the endomembrane system pass materials through each other or though the use of vesicles." [GOC:lh] subset: goslim_candida subset: goslim_flybase_ribbon subset: goslim_yeast xref: Wikipedia:Endomembrane_system is_a: GO:0110165 ! cellular anatomical structure relationship: BFO:0000050 CL:0000000 ! part of cell relationship: BFO:0000051 GO:0005773 ! has part vacuole relationship: BFO:0000051 GO:0005886 ! has part plasma membrane [Term] id: GO:0012506 name: vesicle membrane namespace: cellular_component def: "The lipid bilayer surrounding any membrane-bounded vesicle in the cell." [GOC:mah, GOC:vesicle] xref: NIF_Subcellular:sao1153182838 is_a: GO:0031090 ! organelle membrane intersection_of: GO:0016020 ! membrane intersection_of: BFO:0000050 GO:0031982 ! part of vesicle relationship: BFO:0000050 GO:0031982 ! part of vesicle [Term] id: GO:0014000 name: morula development namespace: biological_process def: "The process whose specific outcome is the progression of the morula over time. The morula is a spherical embryonic mass of blastomeres formed before the blastula and resulting from cleavage of the fertilized ovum." [PMID:37935903, PMID:38386558, PMID:39361745] is_a: GO:0009790 ! embryo development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0000085 ! results in development of morula relationship: RO:0002296 UBERON:0000085 ! results in development of morula property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/29162" xsd:anyURI creation_date: 2024-11-12T09:13:07Z [Term] id: GO:0014002 name: astrocyte development namespace: biological_process def: "The process aimed at the progression of an astrocyte over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. An astrocyte is the most abundant type of glial cell. Astrocytes provide support for neurons and regulate the environment in which they function." [GOC:dgh, GOC:ef] synonym: "astrocyte cell development" EXACT [] is_a: GO:0021782 ! glial cell development intersection_of: GO:0032502 ! developmental process intersection_of: RO:0002296 CL:0000127 ! results in development of astrocyte relationship: BFO:0000050 GO:0048708 ! part of astrocyte differentiation relationship: RO:0002296 CL:0000127 ! results in development of astrocyte [Term] id: GO:0014003 name: oligodendrocyte development namespace: biological_process def: "The process aimed at the progression of an oligodendrocyte over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. An oligodendrocyte is a type of glial cell involved in myelinating the axons in the central nervous system." [GOC:dgh, GOC:ef] synonym: "oligodendrocyte cell development" EXACT [] is_a: GO:0021782 ! glial cell development intersection_of: GO:0032502 ! developmental process intersection_of: RO:0002296 CL:0000128 ! results in development of oligodendrocyte relationship: BFO:0000050 GO:0048709 ! part of oligodendrocyte differentiation relationship: RO:0002296 CL:0000128 ! results in development of oligodendrocyte [Term] id: GO:0014004 name: microglia differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a microglial cell. Microglia are glial cells that act as the immune cells of the central nervous system. They form part of the supporting structure of this system." [GOC:ef] synonym: "microglial cell differentiation" EXACT [] is_a: GO:0010001 ! glial cell differentiation is_a: GO:0030225 ! macrophage differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000129 ! results in acquisition of features of microglial cell relationship: BFO:0000050 GO:0007417 ! part of central nervous system development relationship: RO:0002315 CL:0000129 ! results in acquisition of features of microglial cell [Term] id: GO:0014005 name: microglia development namespace: biological_process def: "The process aimed at the progression of a microglial cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell." [GOC:dgh, GOC:ef] synonym: "microglial cell development" EXACT [] is_a: GO:0021782 ! glial cell development is_a: GO:0061515 ! myeloid cell development intersection_of: GO:0032502 ! developmental process intersection_of: RO:0002296 CL:0000129 ! results in development of microglial cell relationship: BFO:0000050 GO:0014004 ! part of microglia differentiation relationship: RO:0002296 CL:0000129 ! results in development of microglial cell [Term] id: GO:0014006 name: regulation of microglia differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of microglia differentiation, the process in which a relatively unspecialized cell acquires specialized features of a microglial cell." [GOC:ef] synonym: "regulation of microglial cell differentiation" EXACT [] is_a: GO:0045649 ! regulation of macrophage differentiation is_a: GO:0045685 ! regulation of glial cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0014004 ! regulates microglia differentiation relationship: RO:0002211 GO:0014004 ! regulates microglia differentiation [Term] id: GO:0014007 name: negative regulation of microglia differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of microglia differentiation, the process in which a relatively unspecialized cell acquires specialized features of a microglial cell." [GOC:ef] synonym: "down regulation of microglia differentiation" EXACT [] synonym: "down-regulation of microglia differentiation" EXACT [] synonym: "downregulation of microglia differentiation" EXACT [] synonym: "inhibition of microglia differentiation" NARROW [] synonym: "negative regulation of microglial cell differentiation" EXACT [] is_a: GO:0014006 ! regulation of microglia differentiation is_a: GO:0045650 ! negative regulation of macrophage differentiation is_a: GO:0045686 ! negative regulation of glial cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0014004 ! negatively regulates microglia differentiation relationship: RO:0002212 GO:0014004 ! negatively regulates microglia differentiation [Term] id: GO:0014008 name: positive regulation of microglia differentiation namespace: biological_process def: "Any process that activates, maintains or increases the frequency, rate or extent of microglia differentiation, the process in which a relatively unspecialized cell acquires specialized features of a microglial cell." [GOC:ef] synonym: "activation of microglia differentiation" NARROW [] synonym: "positive regulation of microglial cell differentiation" EXACT [] synonym: "stimulation of microglia differentiation" NARROW [] synonym: "up regulation of microglia differentiation" EXACT [] synonym: "up-regulation of microglia differentiation" EXACT [] synonym: "upregulation of microglia differentiation" EXACT [] is_a: GO:0014006 ! regulation of microglia differentiation is_a: GO:0045651 ! positive regulation of macrophage differentiation is_a: GO:0045687 ! positive regulation of glial cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0014004 ! positively regulates microglia differentiation relationship: RO:0002213 GO:0014004 ! positively regulates microglia differentiation [Term] id: GO:0014009 name: glial cell proliferation namespace: biological_process def: "The multiplication or reproduction of glial cells by cell division, resulting in the expansion of their population. Glial cells exist throughout the nervous system, and include Schwann cells, astrocytes, and oligodendrocytes among others." [GOC:ef, ISBN:0878932585] synonym: "glia proliferation" EXACT [] is_a: BFO:0000003 is_a: GO:0008283 ! cell population proliferation intersection_of: GO:0008283 ! cell population proliferation intersection_of: RO:0012003 CL:0000125 ! acts on population of glial cell relationship: BFO:0000050 GO:0042063 ! part of gliogenesis relationship: RO:0012003 CL:0000125 ! acts on population of glial cell [Term] id: GO:0014010 name: Schwann cell proliferation namespace: biological_process def: "The multiplication or reproduction of Schwann cells, resulting in the expansion of their population. Schwann cells are a type of glial cell in the peripheral nervous system." [GOC:ef, ISBN:0878932585] is_a: GO:0014009 ! glial cell proliferation intersection_of: GO:0008283 ! cell population proliferation intersection_of: RO:0012003 CL:0000218 ! acts on population of myelinating Schwann cell relationship: RO:0012003 CL:0000218 ! acts on population of myelinating Schwann cell [Term] id: GO:0014013 name: regulation of gliogenesis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of gliogenesis, the formation of mature glia." [GOC:ef] is_a: GO:0050767 ! regulation of neurogenesis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0042063 ! regulates gliogenesis relationship: RO:0002211 GO:0042063 ! regulates gliogenesis [Term] id: GO:0014014 name: negative regulation of gliogenesis namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of gliogenesis, the formation of mature glia." [GOC:ef] synonym: "down regulation of gliogenesis" EXACT [] synonym: "down-regulation of gliogenesis" EXACT [] synonym: "downregulation of gliogenesis" EXACT [] synonym: "inhibition of gliogenesis" NARROW [] is_a: GO:0014013 ! regulation of gliogenesis is_a: GO:0050768 ! negative regulation of neurogenesis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0042063 ! negatively regulates gliogenesis relationship: RO:0002212 GO:0042063 ! negatively regulates gliogenesis [Term] id: GO:0014015 name: positive regulation of gliogenesis namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of gliogenesis, the formation of mature glia." [GOC:ef] synonym: "activation of gliogenesis" NARROW [] synonym: "stimulation of gliogenesis" NARROW [] synonym: "up regulation of gliogenesis" EXACT [] synonym: "up-regulation of gliogenesis" EXACT [] synonym: "upregulation of gliogenesis" EXACT [] is_a: GO:0014013 ! regulation of gliogenesis is_a: GO:0050769 ! positive regulation of neurogenesis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0042063 ! positively regulates gliogenesis relationship: RO:0002213 GO:0042063 ! positively regulates gliogenesis [Term] id: GO:0014016 name: neuroblast differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a neuroblast. There are at least four stages through which the pluripotent cells of epiblast or blastula become neuroblasts." [GOC:ef, ISBN:0878932585] is_a: GO:0030154 ! cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000031 ! results in acquisition of features of neuroblast (sensu Vertebrata) relationship: BFO:0000050 GO:0048699 ! part of generation of neurons relationship: RO:0002315 CL:0000031 ! results in acquisition of features of neuroblast (sensu Vertebrata) [Term] id: GO:0014019 name: neuroblast development namespace: biological_process def: "The process aimed at the progression of a neuroblast over time, from initial commitment of the cell to a specific state, to the mature neuroblast. It does not include processes where the neuroblast turns into a glial cell or a neuron." [GOC:ef, ISBN:0878932585] is_a: GO:0048468 ! cell development intersection_of: GO:0032502 ! developmental process intersection_of: RO:0002296 CL:0000031 ! results in development of neuroblast (sensu Vertebrata) relationship: BFO:0000050 GO:0014016 ! part of neuroblast differentiation relationship: RO:0002296 CL:0000031 ! results in development of neuroblast (sensu Vertebrata) [Term] id: GO:0014020 name: primary neural tube formation namespace: biological_process def: "The formation of the neural tube from an epithelial cell sheet (the neuroepithelium or neural plate). In primary neurulation, the cells surrounding the neural plate direct the neural plate cells to proliferate, invaginate, and pinch off from the surface to form a hollow epithelial tube. Primary neurulation is the typical mechanism of formation of the anterior neural tube." [GOC:ef, ISBN:0878932585, PMID:15327780] synonym: "neural rod cavitation" RELATED [] synonym: "primary neural tube morphogenesis" EXACT [GOC:dph] synonym: "primary neurulation" EXACT [] is_a: GO:0001838 ! embryonic epithelial tube formation relationship: BFO:0000050 GO:0001841 ! part of neural tube formation [Term] id: GO:0014023 name: neural rod formation namespace: biological_process def: "The formation of a solid rod of neurectoderm derived from the neural keel. The neural rod is roughly circular in cross section. Neural rod formation occurs during primary neurulation in teleosts." [GOC:dh, GOC:ef] is_a: BFO:0000003 is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0005068 ! results in formation of anatomical entity neural rod relationship: BFO:0000050 GO:0014020 ! part of primary neural tube formation relationship: RO:0002162 NCBITaxon:32443 ! in taxon Teleostei relationship: RO:0002297 UBERON:0005068 ! results in formation of anatomical entity neural rod [Term] id: GO:0014025 name: neural keel formation namespace: biological_process def: "The formation of a thickened region of the neurectoderm that is roughly triangular in cross section. The neural keel develops from the neural plate and develops into the neural rod. Neural keel formation occurs during primary neurulation in teleosts." [GOC:dh, GOC:ef] is_a: BFO:0000003 is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0007135 ! results in formation of anatomical entity neural keel relationship: BFO:0000050 GO:0014023 ! part of neural rod formation relationship: RO:0002297 UBERON:0007135 ! results in formation of anatomical entity neural keel [Term] id: GO:0014028 name: notochord formation namespace: biological_process def: "The formation of the notochord from the chordamesoderm. The notochord is composed of large cells packed within a firm connective tissue sheath and is found in all chordates at the ventral surface of the neural tube. In vertebrates, the notochord contributes to the vertebral column." [GOC:dh, GOC:ef] is_a: BFO:0000003 is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0002328 ! results in formation of anatomical entity notochord relationship: BFO:0000050 GO:0007399 ! part of nervous system development relationship: BFO:0000050 GO:0048570 ! part of notochord morphogenesis relationship: RO:0002297 UBERON:0002328 ! results in formation of anatomical entity notochord [Term] id: GO:0014029 name: neural crest formation namespace: biological_process def: "The formation of the specialized region of ectoderm between the neural ectoderm (neural plate) and non-neural ectoderm. The neural crest gives rise to the neural crest cells that migrate away from this region as neural tube formation proceeds." [GOC:dh, GOC:ef] is_a: GO:0001837 ! epithelial to mesenchymal transition is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0002342 ! results in formation of anatomical entity neural crest relationship: BFO:0000050 GO:0043009 ! part of chordate embryonic development relationship: RO:0002162 NCBITaxon:89593 ! in taxon Craniata relationship: RO:0002297 UBERON:0002342 ! results in formation of anatomical entity neural crest [Term] id: GO:0014031 name: mesenchymal cell development namespace: biological_process def: "The process aimed at the progression of a mesenchymal cell over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell." [GOC:dh, GOC:ef] is_a: GO:0048468 ! cell development intersection_of: GO:0032502 ! developmental process intersection_of: RO:0002296 CL:0008019 ! results in development of mesenchymal cell relationship: BFO:0000050 GO:0048762 ! part of mesenchymal cell differentiation relationship: RO:0002296 CL:0008019 ! results in development of mesenchymal cell [Term] id: GO:0014032 name: neural crest cell development namespace: biological_process def: "The process aimed at the progression of a neural crest cell over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell." [GOC:dh, GOC:ef] is_a: GO:0048864 ! stem cell development intersection_of: GO:0032502 ! developmental process intersection_of: RO:0002296 CL:0011012 ! results in development of neural crest cell relationship: BFO:0000050 GO:0014033 ! part of neural crest cell differentiation relationship: RO:0002296 CL:0011012 ! results in development of neural crest cell [Term] id: GO:0014033 name: neural crest cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a neural crest cell." [GOC:dh, GOC:ef] is_a: GO:0048762 ! mesenchymal cell differentiation is_a: GO:0048863 ! stem cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000333 ! results in acquisition of features of migratory neural crest cell relationship: RO:0002162 NCBITaxon:89593 ! in taxon Craniata relationship: RO:0002315 CL:0000333 ! results in acquisition of features of migratory neural crest cell [Term] id: GO:0014037 name: Schwann cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires the specialized features of a Schwann cell. Schwann cells are found in the peripheral nervous system, where they insulate neurons and axons, and regulate the environment in which neurons function." [GOC:ef] is_a: GO:0010001 ! glial cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000218 ! results in acquisition of features of myelinating Schwann cell relationship: BFO:0000050 GO:0007422 ! part of peripheral nervous system development relationship: RO:0002162 NCBITaxon:89593 ! in taxon Craniata relationship: RO:0002315 CL:0000218 ! results in acquisition of features of myelinating Schwann cell [Term] id: GO:0014038 name: regulation of Schwann cell differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of Schwann cell differentiation." [GOC:ef] is_a: GO:0045685 ! regulation of glial cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0014037 ! regulates Schwann cell differentiation relationship: RO:0002211 GO:0014037 ! regulates Schwann cell differentiation [Term] id: GO:0014039 name: negative regulation of Schwann cell differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of Schwann cell differentiation." [GOC:ef] synonym: "down regulation of Schwann cell differentiation" EXACT [] synonym: "down-regulation of Schwann cell differentiation" EXACT [] synonym: "downregulation of Schwann cell differentiation" EXACT [] synonym: "inhibition of Schwann cell differentiation" NARROW [] is_a: GO:0014038 ! regulation of Schwann cell differentiation is_a: GO:0045686 ! negative regulation of glial cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0014037 ! negatively regulates Schwann cell differentiation relationship: RO:0002212 GO:0014037 ! negatively regulates Schwann cell differentiation [Term] id: GO:0014040 name: positive regulation of Schwann cell differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of Schwann cell differentiation." [GOC:ef] synonym: "activation of Schwann cell differentiation" NARROW [] synonym: "stimulation of Schwann cell differentiation" NARROW [] synonym: "up regulation of Schwann cell differentiation" EXACT [] synonym: "up-regulation of Schwann cell differentiation" EXACT [] synonym: "upregulation of Schwann cell differentiation" EXACT [] is_a: GO:0014038 ! regulation of Schwann cell differentiation is_a: GO:0045687 ! positive regulation of glial cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0014037 ! positively regulates Schwann cell differentiation relationship: RO:0002213 GO:0014037 ! positively regulates Schwann cell differentiation [Term] id: GO:0014041 name: regulation of neuron maturation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of neuron maturation, the process leading to the attainment of the full functional capacity of a neuron. This process is independent of morphogenetic change." [GOC:ef] is_a: GO:0045664 ! regulation of neuron differentiation is_a: GO:1903429 ! regulation of cell maturation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0042551 ! regulates neuron maturation relationship: RO:0002211 GO:0042551 ! regulates neuron maturation [Term] id: GO:0014042 name: positive regulation of neuron maturation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of neuron maturation." [GOC:ef] synonym: "activation of neuron maturation" NARROW [] synonym: "stimulation of neuron maturation" NARROW [] synonym: "up regulation of neuron maturation" EXACT [] synonym: "up-regulation of neuron maturation" EXACT [] synonym: "upregulation of neuron maturation" EXACT [] is_a: GO:0014041 ! regulation of neuron maturation is_a: GO:1903431 ! positive regulation of cell maturation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0042551 ! positively regulates neuron maturation relationship: RO:0002213 GO:0042551 ! positively regulates neuron maturation [Term] id: GO:0014043 name: negative regulation of neuron maturation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of neuron maturation." [GOC:ef] synonym: "down regulation of neuron maturation" EXACT [] synonym: "down-regulation of neuron maturation" EXACT [] synonym: "downregulation of neuron maturation" EXACT [] synonym: "inhibition of neuron maturation" NARROW [] is_a: GO:0014041 ! regulation of neuron maturation is_a: GO:1903430 ! negative regulation of cell maturation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0042551 ! negatively regulates neuron maturation relationship: RO:0002212 GO:0042551 ! negatively regulates neuron maturation [Term] id: GO:0014044 name: Schwann cell development namespace: biological_process def: "The process aimed at the progression of a Schwann cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. Schwann cells are found in the peripheral nervous system, where they insulate neurons and axons, and regulate the environment in which neurons function." [GOC:dgh, GOC:ef] is_a: GO:0021782 ! glial cell development intersection_of: GO:0032502 ! developmental process intersection_of: RO:0002296 CL:0000218 ! results in development of myelinating Schwann cell relationship: BFO:0000050 GO:0014037 ! part of Schwann cell differentiation relationship: RO:0002296 CL:0000218 ! results in development of myelinating Schwann cell [Term] id: GO:0014046 name: dopamine secretion namespace: biological_process def: "The regulated release of dopamine by a cell. Dopamine is a catecholamine and a precursor of adrenaline and noradrenaline. It acts as a neurotransmitter in the central nervous system but it is also produced peripherally and acts as a hormone." [GOC:ef] is_a: GO:0015872 ! dopamine transport is_a: GO:0023061 ! signal release is_a: GO:0050432 ! catecholamine secretion intersection_of: GO:0046903 ! secretion intersection_of: RO:0004009 CHEBI:59905 ! has primary input [Term] id: GO:0014047 name: glutamate secretion namespace: biological_process def: "The controlled release of glutamate by a cell. The glutamate is the most abundant excitatory neurotransmitter in the nervous system." [GOC:ef] is_a: GO:0006835 ! dicarboxylic acid transport is_a: GO:0015800 ! acidic amino acid transport is_a: GO:0032940 ! secretion by cell is_a: GO:0071705 ! nitrogen compound transport intersection_of: GO:0046903 ! secretion intersection_of: RO:0004009 CHEBI:14321 ! has primary input relationship: RO:0004009 CHEBI:14321 ! has primary input [Term] id: GO:0014048 name: regulation of glutamate secretion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the controlled release of glutamate." [GOC:ef] is_a: GO:0032890 ! regulation of organic acid transport is_a: GO:0051955 ! regulation of amino acid transport is_a: GO:1903530 ! regulation of secretion by cell intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0014047 ! regulates glutamate secretion relationship: RO:0002211 GO:0014047 ! regulates glutamate secretion [Term] id: GO:0014049 name: positive regulation of glutamate secretion namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the controlled release of glutamate." [GOC:ef] synonym: "activation of glutamate secretion" NARROW [] synonym: "stimulation of glutamate secretion" NARROW [] synonym: "up regulation of glutamate secretion" EXACT [] synonym: "up-regulation of glutamate secretion" EXACT [] synonym: "upregulation of glutamate secretion" EXACT [] is_a: GO:0014048 ! regulation of glutamate secretion is_a: GO:0032892 ! positive regulation of organic acid transport is_a: GO:0051957 ! positive regulation of amino acid transport is_a: GO:1903532 ! positive regulation of secretion by cell intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0014047 ! positively regulates glutamate secretion relationship: RO:0002213 GO:0014047 ! positively regulates glutamate secretion [Term] id: GO:0014050 name: negative regulation of glutamate secretion namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the controlled release of glutamate." [GOC:ef] synonym: "down regulation of glutamate secretion" EXACT [] synonym: "down-regulation of glutamate secretion" EXACT [] synonym: "downregulation of glutamate secretion" EXACT [] synonym: "inhibition of glutamate secretion" NARROW [] is_a: GO:0014048 ! regulation of glutamate secretion is_a: GO:0032891 ! negative regulation of organic acid transport is_a: GO:0051956 ! negative regulation of amino acid transport is_a: GO:1903531 ! negative regulation of secretion by cell intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0014047 ! negatively regulates glutamate secretion relationship: RO:0002212 GO:0014047 ! negatively regulates glutamate secretion [Term] id: GO:0014051 name: gamma-aminobutyric acid secretion namespace: biological_process def: "The regulated release of gamma-aminobutyric acid by a cell or a tissue. The gamma-aminobutyric acid is the principal inhibitory neurotransmitter in the brain but is also found in several extraneural tissues." [GOC:ef] synonym: "GABA secretion" EXACT [] is_a: GO:0015812 ! gamma-aminobutyric acid transport is_a: GO:0046717 ! acid secretion intersection_of: GO:0046903 ! secretion intersection_of: RO:0004009 CHEBI:59888 ! has primary input [Term] id: GO:0014052 name: regulation of gamma-aminobutyric acid secretion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the regulated release of gamma-aminobutyric acid." [GOC:ef] synonym: "regulation of GABA secretion" EXACT [] is_a: GO:0032890 ! regulation of organic acid transport is_a: GO:0051046 ! regulation of secretion is_a: GO:0051955 ! regulation of amino acid transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0014051 ! regulates gamma-aminobutyric acid secretion relationship: RO:0002211 GO:0014051 ! regulates gamma-aminobutyric acid secretion [Term] id: GO:0014053 name: negative regulation of gamma-aminobutyric acid secretion namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of gamma-aminobutyric acid." [GOC:ef] synonym: "down regulation of gamma-aminobutyric acid secretion" EXACT [] synonym: "down-regulation of gamma-aminobutyric acid secretion" EXACT [] synonym: "downregulation of gamma-aminobutyric acid secretion" EXACT [] synonym: "inhibition of gamma-aminobutyric acid secretion" NARROW [] synonym: "negative regulation of GABA secretion" EXACT [] is_a: GO:0014052 ! regulation of gamma-aminobutyric acid secretion is_a: GO:0032891 ! negative regulation of organic acid transport is_a: GO:0051048 ! negative regulation of secretion is_a: GO:0051956 ! negative regulation of amino acid transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0014051 ! negatively regulates gamma-aminobutyric acid secretion relationship: RO:0002212 GO:0014051 ! negatively regulates gamma-aminobutyric acid secretion [Term] id: GO:0014054 name: positive regulation of gamma-aminobutyric acid secretion namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the regulated release of gamma-aminobutyric acid." [GOC:ef] synonym: "activation of gamma-aminobutyric acid secretion" NARROW [] synonym: "positive regulation of GABA secretion" EXACT [] synonym: "stimulation of gamma-aminobutyric acid secretion" NARROW [] synonym: "up regulation of gamma-aminobutyric acid secretion" EXACT [] synonym: "up-regulation of gamma-aminobutyric acid secretion" EXACT [] synonym: "upregulation of gamma-aminobutyric acid secretion" EXACT [] is_a: GO:0014052 ! regulation of gamma-aminobutyric acid secretion is_a: GO:0032892 ! positive regulation of organic acid transport is_a: GO:0051047 ! positive regulation of secretion is_a: GO:0051957 ! positive regulation of amino acid transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0014051 ! positively regulates gamma-aminobutyric acid secretion relationship: RO:0002213 GO:0014051 ! positively regulates gamma-aminobutyric acid secretion [Term] id: GO:0014055 name: acetylcholine secretion, neurotransmission namespace: biological_process def: "The regulated release of acetylcholine by a cell. The acetylcholine acts as a neurotransmitter that acts in both the peripheral nervous system (PNS) and central nervous system (CNS)." [GOC:ef] is_a: GO:0007269 ! neurotransmitter secretion is_a: GO:0061526 ! acetylcholine secretion intersection_of: GO:0061526 ! acetylcholine secretion intersection_of: BFO:0000050 GO:0007271 ! part of synaptic transmission, cholinergic relationship: BFO:0000050 GO:0007271 ! part of synaptic transmission, cholinergic [Term] id: GO:0014056 name: regulation of acetylcholine secretion, neurotransmission namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the regulated release of acetylcholine." [GOC:ef] is_a: GO:0032222 ! regulation of synaptic transmission, cholinergic is_a: GO:0046928 ! regulation of neurotransmitter secretion is_a: GO:0051952 ! regulation of amine transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0014055 ! regulates acetylcholine secretion, neurotransmission relationship: RO:0002211 GO:0014055 ! regulates acetylcholine secretion, neurotransmission [Term] id: GO:0014057 name: positive regulation of acetylcholine secretion, neurotransmission namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the regulated release of acetylcholine." [GOC:ef] synonym: "activation of acetylcholine secretion" NARROW [] synonym: "stimulation of acetylcholine secretion" NARROW [] synonym: "up regulation of acetylcholine secretion" EXACT [] synonym: "up-regulation of acetylcholine secretion" EXACT [] synonym: "upregulation of acetylcholine secretion" EXACT [] is_a: GO:0001956 ! positive regulation of neurotransmitter secretion is_a: GO:0014056 ! regulation of acetylcholine secretion, neurotransmission is_a: GO:0032224 ! positive regulation of synaptic transmission, cholinergic is_a: GO:0051954 ! positive regulation of amine transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0014055 ! positively regulates acetylcholine secretion, neurotransmission relationship: RO:0002213 GO:0014055 ! positively regulates acetylcholine secretion, neurotransmission [Term] id: GO:0014058 name: negative regulation of acetylcholine secretion, neurotransmission namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of acetylcholine." [GOC:ef] synonym: "down regulation of acetylcholine secretion" EXACT [] synonym: "down-regulation of acetylcholine secretion" EXACT [] synonym: "downregulation of acetylcholine secretion" EXACT [] synonym: "inhibition of acetylcholine secretion" NARROW [] is_a: GO:0014056 ! regulation of acetylcholine secretion, neurotransmission is_a: GO:0032223 ! negative regulation of synaptic transmission, cholinergic is_a: GO:0046929 ! negative regulation of neurotransmitter secretion is_a: GO:0051953 ! negative regulation of amine transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0014055 ! negatively regulates acetylcholine secretion, neurotransmission relationship: RO:0002212 GO:0014055 ! negatively regulates acetylcholine secretion, neurotransmission [Term] id: GO:0014059 name: regulation of dopamine secretion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the regulated release of dopamine." [GOC:ef] is_a: GO:0050433 ! regulation of catecholamine secretion intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0014046 ! regulates dopamine secretion relationship: RO:0002211 GO:0014046 ! regulates dopamine secretion [Term] id: GO:0014060 name: regulation of epinephrine secretion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the regulated release of epinephrine." [GOC:ef] synonym: "regulation of adrenaline secretion" EXACT [] is_a: GO:0050433 ! regulation of catecholamine secretion intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0048242 ! regulates epinephrine secretion relationship: RO:0002211 GO:0048242 ! regulates epinephrine secretion [Term] id: GO:0014061 name: regulation of norepinephrine secretion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the regulated release of norepinephrine." [GOC:ef] synonym: "regulation of noradrenaline secretion" EXACT [] is_a: GO:0050433 ! regulation of catecholamine secretion intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0048243 ! regulates norepinephrine secretion relationship: RO:0002211 GO:0048243 ! regulates norepinephrine secretion [Term] id: GO:0014062 name: regulation of serotonin secretion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the regulated release of serotonin." [GOC:ef] synonym: "regulation of serotonin release" RELATED [GOC:tb] is_a: GO:0043269 ! regulation of monoatomic ion transport is_a: GO:1903530 ! regulation of secretion by cell intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0001820 ! regulates serotonin secretion relationship: RO:0002211 GO:0001820 ! regulates serotonin secretion [Term] id: GO:0014063 name: negative regulation of serotonin secretion namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of serotonin." [GOC:ef] synonym: "down regulation of serotonin secretion" EXACT [] synonym: "down-regulation of serotonin secretion" EXACT [] synonym: "downregulation of serotonin secretion" EXACT [] synonym: "inhibition of serotonin secretion" NARROW [] synonym: "positive regulation of serotonin release" RELATED [GOC:tb] is_a: GO:0014062 ! regulation of serotonin secretion is_a: GO:0043271 ! negative regulation of monoatomic ion transport is_a: GO:1903531 ! negative regulation of secretion by cell intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0001820 ! negatively regulates serotonin secretion relationship: RO:0002212 GO:0001820 ! negatively regulates serotonin secretion [Term] id: GO:0014064 name: positive regulation of serotonin secretion namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the regulated release of serotonin." [GOC:ef] synonym: "activation of serotonin secretion" NARROW [] synonym: "positive regulation of serotonin release" RELATED [GOC:tb] synonym: "stimulation of serotonin secretion" NARROW [] synonym: "up regulation of serotonin secretion" EXACT [] synonym: "up-regulation of serotonin secretion" EXACT [] synonym: "upregulation of serotonin secretion" EXACT [] is_a: GO:0014062 ! regulation of serotonin secretion is_a: GO:0043270 ! positive regulation of monoatomic ion transport is_a: GO:1903532 ! positive regulation of secretion by cell intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0001820 ! positively regulates serotonin secretion relationship: RO:0002213 GO:0001820 ! positively regulates serotonin secretion [Term] id: GO:0014074 name: response to purine-containing compound namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a purine-containing compound stimulus." [GOC:ef] synonym: "response to purine" RELATED [] is_a: GO:1901698 ! response to nitrogen compound intersection_of: GO:0050896 ! response to stimulus intersection_of: RO:0004009 CHEBI:26401 ! has primary input relationship: RO:0004009 CHEBI:26401 ! has primary input [Term] id: GO:0014075 name: response to amine namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amine stimulus. An amine is a compound formally derived from ammonia by replacing one, two or three hydrogen atoms by hydrocarbyl groups." [GOC:ef] synonym: "response to amine stimulus" EXACT [GOC:dos] is_a: GO:1901698 ! response to nitrogen compound intersection_of: GO:0050896 ! response to stimulus intersection_of: RO:0004009 CHEBI:32952 ! has primary input relationship: RO:0004009 CHEBI:32952 ! has primary input [Term] id: GO:0014706 name: striated muscle tissue development namespace: biological_process def: "The process whose specific outcome is the progression of a striated muscle over time, from its formation to the mature structure. Striated muscle contain fibers that are divided by transverse bands into striations, and cardiac and skeletal muscle are types of striated muscle. Skeletal muscle myoblasts fuse to form myotubes and eventually multinucleated muscle fibers. The fusion of cardiac cells is very rare and can only form binucleate cells." [CL:0000737, GOC:dph, GOC:mtg_muscle] is_a: GO:0060537 ! muscle tissue development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0002036 ! results in development of striated muscle tissue relationship: RO:0002296 UBERON:0002036 ! results in development of striated muscle tissue [Term] id: GO:0014707 name: branchiomeric skeletal muscle development namespace: biological_process def: "The process whose specific outcome is the progression of the branchiomeric skeletal muscle over time, from its formation to the mature structure. The branchiomeric muscle is derived from cranial mesoderm and controls facial expression, pharyngeal and laryngeal function, operating the jaw. The muscle begins its development with the differentiation of the muscle cells and ends with the mature muscle. Branchiomeric muscles of mammals correspond to the gill musculature of fish." [GOC:mtg_muscle] is_a: GO:0007517 ! muscle organ development is_a: GO:0007519 ! skeletal muscle tissue development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0004164 ! results in development of branchiomeric muscle relationship: RO:0002296 UBERON:0004164 ! results in development of branchiomeric muscle [Term] id: GO:0014711 name: regulation of branchiomeric skeletal muscle development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of branchiomeric skeletal muscle development. Branchiomeric skeletal muscle development is the process whose specific outcome is the progression of the branchiomeric skeletal muscle over time, from its formation to the mature structure." [GOC:mtg_muscle] is_a: GO:0048641 ! regulation of skeletal muscle tissue development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0014707 ! regulates branchiomeric skeletal muscle development relationship: RO:0002211 GO:0014707 ! regulates branchiomeric skeletal muscle development [Term] id: GO:0014712 name: positive regulation of branchiomeric skeletal muscle development namespace: biological_process def: "Any process that activates, maintains or increases the frequency, rate or extent of branchiomeric skeletal muscle development. Branchiomeric skeletal muscle development is the process whose specific outcome is the progression of the branchiomeric skeletal muscle over time, from its formation to the mature structure." [GOC:mtg_muscle] is_a: GO:0014711 ! regulation of branchiomeric skeletal muscle development is_a: GO:0048643 ! positive regulation of skeletal muscle tissue development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0014707 ! positively regulates branchiomeric skeletal muscle development relationship: RO:0002213 GO:0014707 ! positively regulates branchiomeric skeletal muscle development [Term] id: GO:0014713 name: negative regulation of branchiomeric skeletal muscle development namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of branchiomeric skeletal muscle development. Branchiomeric skeletal muscle development is the process whose specific outcome is the progression of the branchiomeric skeletal muscle over time, from its formation to the mature structure." [GOC:mtg_muscle] is_a: GO:0014711 ! regulation of branchiomeric skeletal muscle development is_a: GO:0048642 ! negative regulation of skeletal muscle tissue development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0014707 ! negatively regulates branchiomeric skeletal muscle development relationship: RO:0002212 GO:0014707 ! negatively regulates branchiomeric skeletal muscle development [Term] id: GO:0014716 name: skeletal muscle satellite stem cell asymmetric division involved in skeletal muscle regeneration namespace: biological_process def: "Skeletal muscle satellite cell asymmetric division that occurs during a process in which damaged muscle tissue is being rebuilt." [GOC:mtg_muscle] comment: Occurrence of this process outside of the context of muscle repair is probably very rare, so there is a good case for merging this with the parent class. synonym: "satellite cell asymmetric division involved in skeletal muscle regeneration" EXACT [] is_a: GO:0014833 ! skeletal muscle satellite stem cell asymmetric division intersection_of: GO:0014833 ! skeletal muscle satellite stem cell asymmetric division intersection_of: BFO:0000050 GO:0043403 ! part of skeletal muscle tissue regeneration relationship: BFO:0000050 GO:0014834 ! part of skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration [Term] id: GO:0014717 name: regulation of satellite cell activation involved in skeletal muscle regeneration namespace: biological_process def: "Any process that modulates the frequency, rate or extent of satellite cell activation. The satellite cell activation is the process that initiates satellite cell division by causing it to move from quiescence to the G1 stage of the cell cycle. The cell swells and there are a number of other small changes. The cells then start to divide. Following cell division the cells will differentiate." [GOC:mtg_muscle] is_a: GO:0043416 ! regulation of skeletal muscle tissue regeneration is_a: GO:0050865 ! regulation of cell activation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0014901 ! regulates satellite cell activation involved in skeletal muscle regeneration relationship: RO:0002211 GO:0014901 ! regulates satellite cell activation involved in skeletal muscle regeneration [Term] id: GO:0014718 name: positive regulation of satellite cell activation involved in skeletal muscle regeneration namespace: biological_process def: "Any process that activates, maintains or increases the frequency, rate or extent of activation of satellite cell involved in skeletal muscle regeneration. The activation of satellite cell is the process that initiates satellite cell division by causing it to move from quiescence to the G1 stage of the cell cycle. The cell swells and there are a number of other small changes. The cells then start to divide. Following cell division the cells will differentiate." [GOC:mtg_muscle] is_a: GO:0014717 ! regulation of satellite cell activation involved in skeletal muscle regeneration is_a: GO:0043415 ! positive regulation of skeletal muscle tissue regeneration is_a: GO:0050867 ! positive regulation of cell activation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0014901 ! positively regulates satellite cell activation involved in skeletal muscle regeneration relationship: RO:0002213 GO:0014901 ! positively regulates satellite cell activation involved in skeletal muscle regeneration [Term] id: GO:0014719 name: skeletal muscle satellite cell activation namespace: biological_process def: "The change of a skeletal muscle satellite cell from a mitotically quiescent to a mitotically active state following exposure to some activating factor such as a cellular or soluble ligand. In adult muscle, satellite cells become activated to divide and differentiate in response to muscle damage." [GOC:mtg_muscle, PMID:23303905] is_a: BFO:0000003 is_a: GO:0001775 ! cell activation intersection_of: GO:0001775 ! cell activation intersection_of: RO:0002315 CL:0008016 ! results in acquisition of features of activated skeletal muscle satellite cell intersection_of: RO:0004009 CL:0008012 ! has primary input quiescent skeletal muscle satellite cell relationship: RO:0002162 NCBITaxon:7742 ! in taxon Vertebrata relationship: RO:0002315 CL:0008016 ! results in acquisition of features of activated skeletal muscle satellite cell relationship: RO:0004009 CL:0008012 ! has primary input quiescent skeletal muscle satellite cell [Term] id: GO:0014722 name: regulation of skeletal muscle contraction by calcium ion signaling namespace: biological_process def: "Any process that modulates the frequency, rate or extent of skeletal muscle contraction by changing the calcium ion signals that trigger contraction." [GOC:mtg_muscle] synonym: "regulation of skeletal muscle contraction by calcium ion signalling" EXACT [] is_a: GO:0014819 ! regulation of skeletal muscle contraction is_a: GO:0019722 ! calcium-mediated signaling intersection_of: GO:0019722 ! calcium-mediated signaling intersection_of: RO:0002211 GO:0003009 ! regulates skeletal muscle contraction [Term] id: GO:0014725 name: regulation of extraocular skeletal muscle development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of extraocular skeletal muscle development. Extraocular skeletal muscle development is the process whose specific outcome is the progression of the extraocular skeletal muscle over time, from its formation to the mature structure. The extraocular muscle is derived from cranial mesoderm and controls eye movements. The muscle begins its development with the differentiation of the muscle cells and ends with the mature muscle." [GOC:mtg_muscle] is_a: GO:0048641 ! regulation of skeletal muscle tissue development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0002074 ! regulates extraocular skeletal muscle development relationship: RO:0002211 GO:0002074 ! regulates extraocular skeletal muscle development [Term] id: GO:0014726 name: negative regulation of extraocular skeletal muscle development namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of extraocular skeletal muscle development. Extraocular skeletal muscle development is the process whose specific outcome is the progression of the extraocular skeletal muscle over time, from its formation to the mature structure. The extraocular muscle is derived from cranial mesoderm and controls eye movements. The muscle begins its development with the differentiation of the muscle cells and ends with the mature muscle." [GOC:mtg_muscle] is_a: GO:0014725 ! regulation of extraocular skeletal muscle development is_a: GO:0048642 ! negative regulation of skeletal muscle tissue development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0002074 ! negatively regulates extraocular skeletal muscle development relationship: RO:0002212 GO:0002074 ! negatively regulates extraocular skeletal muscle development [Term] id: GO:0014727 name: positive regulation of extraocular skeletal muscle development namespace: biological_process def: "Any process that activates, maintains or increases the frequency, rate or extent of extraocular skeletal muscle development. Extraocular skeletal muscle development is the process whose specific outcome is the progression of the extraocular skeletal muscle over time, from its formation to the mature structure. The extraocular muscle is derived from cranial mesoderm and controls eye movements. The muscle begins its development with the differentiation of the muscle cells and ends with the mature muscle." [GOC:mtg_muscle] is_a: GO:0014725 ! regulation of extraocular skeletal muscle development is_a: GO:0048643 ! positive regulation of skeletal muscle tissue development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0002074 ! positively regulates extraocular skeletal muscle development relationship: RO:0002213 GO:0002074 ! positively regulates extraocular skeletal muscle development [Term] id: GO:0014733 name: regulation of skeletal muscle adaptation namespace: biological_process def: "Any process in which skeletal muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors. These adaptive events occur in both muscle fibers and associated structures (motoneurons and capillaries), and they involve alterations in regulatory mechanisms, contractile properties and metabolic capacities." [GOC:mtg_muscle] synonym: "regulation of skeletal muscle plasticity" RELATED [] is_a: GO:0043502 ! regulation of muscle adaptation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0043501 ! regulates skeletal muscle adaptation relationship: RO:0002211 GO:0043501 ! regulates skeletal muscle adaptation property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0014734 name: skeletal muscle hypertrophy namespace: biological_process def: "The enlargement or overgrowth of all or part of an organ due to an increase in size (not length) of individual muscle fibers without cell division. In the case of skeletal muscle cells this happens due to the additional synthesis of sarcomeric proteins and assembly of myofibrils." [GOC:mtg_muscle] is_a: GO:0014897 ! striated muscle hypertrophy is_a: GO:0043501 ! skeletal muscle adaptation intersection_of: GO:0014896 ! muscle hypertrophy intersection_of: BFO:0000066 UBERON:0001134 ! occurs in skeletal muscle tissue property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0014741 name: negative regulation of muscle hypertrophy namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of muscle hypertrophy." [GOC:mtg_muscle] is_a: GO:0014743 ! regulation of muscle hypertrophy is_a: GO:0051241 ! negative regulation of multicellular organismal process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0014896 ! negatively regulates muscle hypertrophy relationship: RO:0002212 GO:0014896 ! negatively regulates muscle hypertrophy property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0014742 name: positive regulation of muscle hypertrophy namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of muscle hypertrophy." [GOC:mtg_muscle] is_a: GO:0014743 ! regulation of muscle hypertrophy is_a: GO:0051240 ! positive regulation of multicellular organismal process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0014896 ! positively regulates muscle hypertrophy relationship: RO:0002213 GO:0014896 ! positively regulates muscle hypertrophy property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0014743 name: regulation of muscle hypertrophy namespace: biological_process def: "Any process that modulates the frequency, rate or extent of muscle hypertrophy." [GOC:mtg_muscle] is_a: GO:0090257 ! regulation of muscle system process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0014896 ! regulates muscle hypertrophy relationship: RO:0002211 GO:0014896 ! regulates muscle hypertrophy property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0014744 name: positive regulation of muscle adaptation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of muscle adaptation." [GOC:mtg_muscle] synonym: "positive regulation of muscle plasticity" RELATED [] is_a: GO:0043502 ! regulation of muscle adaptation is_a: GO:0048584 ! positive regulation of response to stimulus is_a: GO:0051240 ! positive regulation of multicellular organismal process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0043500 ! positively regulates muscle adaptation relationship: RO:0002213 GO:0043500 ! positively regulates muscle adaptation property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0014745 name: negative regulation of muscle adaptation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of muscle adaptation." [GOC:mtg_muscle] synonym: "negative regulation of muscle plasticity" RELATED [] is_a: GO:0043502 ! regulation of muscle adaptation is_a: GO:0048585 ! negative regulation of response to stimulus is_a: GO:0051241 ! negative regulation of multicellular organismal process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0043500 ! negatively regulates muscle adaptation relationship: RO:0002212 GO:0043500 ! negatively regulates muscle adaptation property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0014805 name: smooth muscle adaptation namespace: biological_process def: "Any process in which smooth muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors. These adaptive events occur in both muscle fibers and associated structures (motoneurons and capillaries), and they involve alterations in regulatory mechanisms, contractile properties and metabolic capacities." [GOC:mtg_muscle] synonym: "smooth muscle plasticity" RELATED [] is_a: GO:0043500 ! muscle adaptation intersection_of: GO:0043500 ! muscle adaptation intersection_of: BFO:0000066 UBERON:0001135 ! occurs in smooth muscle tissue relationship: BFO:0000066 UBERON:0001135 ! occurs in smooth muscle tissue property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0014807 name: regulation of somitogenesis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of somitogenesis." [GOC:mtg_muscle] is_a: GO:0022603 ! regulation of anatomical structure morphogenesis is_a: GO:0051239 ! regulation of multicellular organismal process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0001756 ! regulates somitogenesis relationship: RO:0002211 GO:0001756 ! regulates somitogenesis [Term] id: GO:0014812 name: muscle cell migration namespace: biological_process def: "The orderly movement of a muscle cell from one site to another, often during the development of a multicellular organism." [CL:0000187, GOC:mtg_muscle] is_a: BFO:0000003 is_a: GO:0016477 ! cell migration intersection_of: GO:0016477 ! cell migration intersection_of: RO:0002565 CL:0000187 ! results in movement of muscle cell relationship: RO:0002565 CL:0000187 ! results in movement of muscle cell property_value: RO:0002161 NCBITaxon:4890 [Term] id: GO:0014816 name: skeletal muscle satellite cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a satellite cell." [GOC:ef, GOC:mtg_muscle, PMID:16607119] is_a: GO:0035914 ! skeletal muscle cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000594 ! results in acquisition of features of skeletal muscle satellite cell relationship: RO:0002315 CL:0000594 ! results in acquisition of features of skeletal muscle satellite cell [Term] id: GO:0014819 name: regulation of skeletal muscle contraction namespace: biological_process def: "Any process that modulates the frequency, rate or extent of skeletal muscle contraction." [GOC:ef, GOC:mtg_muscle] is_a: GO:0006942 ! regulation of striated muscle contraction intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0003009 ! regulates skeletal muscle contraction relationship: RO:0002211 GO:0003009 ! regulates skeletal muscle contraction [Term] id: GO:0014821 name: phasic smooth muscle contraction namespace: biological_process def: "A process in which force is generated within phasic smooth muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. In the phasic smooth muscle, the muscle contraction occurs without an ordered sarcomeric structure. Phasic smooth muscle contraction occurs in a series of discrete contractions and relaxations." [GOC:mtg_muscle] is_a: GO:0006939 ! smooth muscle contraction property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0014827 name: intestine smooth muscle contraction namespace: biological_process def: "A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the intestine. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The intestine is the section of the alimentary canal from the stomach to the anal canal. It includes the large intestine and small intestine." [GOC:mtg_muscle, MA:0001539, MSH:D007422] is_a: GO:0014821 ! phasic smooth muscle contraction is_a: GO:0014831 ! gastro-intestinal system smooth muscle contraction property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0014831 name: gastro-intestinal system smooth muscle contraction namespace: biological_process def: "A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the gastro-intestinal system. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The gastro-intestinal system generally refers to the digestive structures stretching from the mouth to anus, but does not include the accessory glandular organs (liver, pancreas and biliary tract)." [GOC:mtg_muscle, MA:0001523, MSH:D041981] is_a: GO:0006939 ! smooth muscle contraction property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0014832 name: urinary bladder smooth muscle contraction namespace: biological_process def: "A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the urinary bladder. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The urinary bladder is a musculomembranous sac along the urinary tract." [GOC:mr, GOC:mtg_muscle, PMID:11768524, PMID:18276178, PMID:538956] is_a: GO:0014848 ! urinary tract smooth muscle contraction property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 property_value: RO:0002161 NCBITaxon:8782 [Term] id: GO:0014833 name: skeletal muscle satellite stem cell asymmetric division namespace: biological_process def: "The asymmetric division of a skeletal muscle satellite stem cell to produce two daughter cells, one of which is destined to differentiate and the other to be a quiescent cell that restocks the satellite cell pool." [GOC:ef, GOC:mtg_muscle, PMID:16607119] synonym: "satellite cell asymmetric division" EXACT [] is_a: GO:0048103 ! somatic stem cell division is_a: GO:0098722 ! asymmetric stem cell division intersection_of: GO:0008356 ! asymmetric cell division intersection_of: RO:0004009 CL:0008011 ! has primary input skeletal muscle satellite stem cell relationship: BFO:0000050 GO:0007519 ! part of skeletal muscle tissue development relationship: RO:0004009 CL:0008011 ! has primary input skeletal muscle satellite stem cell [Term] id: GO:0014834 name: skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration namespace: biological_process def: "Any process by which the number of skeletal muscle satellite cells in a skeletal muscle is maintained during muscle regeneration. There are at least three mechanisms by which this is achieved. Skeletal muscle satellite stem cell asymmetric division ensures satellite stem cell numbers are kept constant. Symmetric division of these cells amplifies the number of skeletal muscle satellite stem cells. Some adult skeletal muscle myoblasts (descendants of activated satellite cells) can develop back into quiescent satellite cells, replenishing the overall pool of satellite cells." [GOC:dph, GOC:ef, GOC:mtg_muscle, GOC:tb, PMID:23303905] synonym: "satellite cell compartment self-renewal involved in skeletal muscle regeneration" EXACT [GOC:dph, GOC:tb] synonym: "satellite cell population maintenance" EXACT [] synonym: "satellite cell self-renewal" BROAD [] is_a: BFO:0000003 is_a: GO:0098727 ! maintenance of cell number intersection_of: GO:0098727 ! maintenance of cell number intersection_of: BFO:0000050 GO:0043403 ! part of skeletal muscle tissue regeneration intersection_of: RO:0012003 CL:0000594 ! acts on population of skeletal muscle satellite cell relationship: BFO:0000050 GO:0043403 ! part of skeletal muscle tissue regeneration relationship: RO:0012003 CL:0000594 ! acts on population of skeletal muscle satellite cell [Term] id: GO:0014835 name: myoblast differentiation involved in skeletal muscle regeneration namespace: biological_process def: "The process in which a relatively unspecialized satellite cell acquires specialized features of a myoblast. This occurs as part of skeletal muscle regeneration. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers." [CL:0000056, GOC:ef, GOC:mtg_muscle, PMID:16607119] is_a: GO:0045445 ! myoblast differentiation intersection_of: GO:0045445 ! myoblast differentiation intersection_of: BFO:0000050 GO:0043403 ! part of skeletal muscle tissue regeneration relationship: BFO:0000050 GO:0043403 ! part of skeletal muscle tissue regeneration [Term] id: GO:0014839 name: myoblast migration involved in skeletal muscle regeneration namespace: biological_process def: "The process in which a myoblast migrates along an entire fiber to the site of injury. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers." [CL:0000056, GOC:ef, GOC:mtg_muscle, PMID:16607119] synonym: "mononucleate cell migration involved in skeletal muscle regeneration" BROAD [] is_a: GO:0051451 ! myoblast migration intersection_of: GO:0051451 ! myoblast migration intersection_of: BFO:0000050 GO:0043403 ! part of skeletal muscle tissue regeneration relationship: BFO:0000050 GO:0043403 ! part of skeletal muscle tissue regeneration [Term] id: GO:0014841 name: skeletal muscle satellite cell proliferation namespace: biological_process def: "The multiplication or reproduction of satellite cells, resulting in the expansion of the cell population. Satellite cells are quiescent cells that are located between the basal lamina and the plasmalemma of the muscle fiber, which are the main contributors to postnatal muscle growth. In adult muscle, satellite cells become activated to divide and differentiate in response to muscle damage." [GOC:ef, GOC:mtg_muscle, PMID:16607119] is_a: GO:0014856 ! skeletal muscle cell proliferation intersection_of: GO:0008283 ! cell population proliferation intersection_of: RO:0012003 CL:0008016 ! acts on population of activated skeletal muscle satellite cell relationship: RO:0012003 CL:0008016 ! acts on population of activated skeletal muscle satellite cell property_value: RO:0002161 NCBITaxon:4751 [Term] id: GO:0014842 name: regulation of skeletal muscle satellite cell proliferation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of skeletal muscle satellite cell proliferation." [GOC:ef, GOC:mtg_muscle, PMID:16607119] is_a: GO:0014857 ! regulation of skeletal muscle cell proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0014841 ! regulates skeletal muscle satellite cell proliferation relationship: RO:0002211 GO:0014841 ! regulates skeletal muscle satellite cell proliferation property_value: RO:0002161 NCBITaxon:4751 [Term] id: GO:0014848 name: urinary tract smooth muscle contraction namespace: biological_process def: "A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the urinary tract. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The urinary tract consists of organs of the body that produce and discharge urine. These include the kidneys, ureters, bladder, and urethra." [GOC:ef, GOC:mtg_muscle, MA:0000325, MSH:D014551] is_a: GO:0006939 ! smooth muscle contraction property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0014849 name: ureter smooth muscle contraction namespace: biological_process def: "A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the ureter. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The ureter is one of a pair of thick-walled tubes that transports urine from the kidney pelvis to the urinary bladder." [GOC:mtg_muscle, MA:0000378] is_a: GO:0014821 ! phasic smooth muscle contraction is_a: GO:0014848 ! urinary tract smooth muscle contraction property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0014852 name: regulation of skeletal muscle contraction by neural stimulation via neuromuscular junction namespace: biological_process def: "Any process that modulates the frequency, rate or extent of skeletal muscle contraction by variation of the pattern of stimulation by nervous system." [GOC:ef, GOC:mtg_muscle] is_a: GO:0014819 ! regulation of skeletal muscle contraction [Term] id: GO:0014853 name: regulation of excitatory postsynaptic membrane potential involved in skeletal muscle contraction namespace: biological_process def: "Any process, involved in skeletal muscle contraction, that modulates the establishment or extent of the excitatory postsynaptic potential (EPSP). Excitatory postsynaptic potential (EPSP) is a temporary increase in postsynaptic potential due to the flow of positively charged ions into the postsynaptic cell. The flow of ions that causes an EPSP is an excitatory postsynaptic current (EPSC) and makes it easier for the neuron to fire an action potential." [GOC:ef, GOC:mtg_muscle] synonym: "regulation of excitatory post-synaptic membrane potential involved in skeletal muscle contraction" EXACT [] is_a: GO:0098815 ! modulation of excitatory postsynaptic potential intersection_of: GO:0098815 ! modulation of excitatory postsynaptic potential intersection_of: BFO:0000050 GO:0003009 ! part of skeletal muscle contraction relationship: BFO:0000050 GO:0003009 ! part of skeletal muscle contraction relationship: BFO:0000050 GO:0014852 ! part of regulation of skeletal muscle contraction by neural stimulation via neuromuscular junction [Term] id: GO:0014855 name: striated muscle cell proliferation namespace: biological_process def: "The multiplication or reproduction of striated muscle cells, resulting in the expansion of a cell population. Striated muscles contain fibers that are divided by transverse bands into striations, and cardiac and skeletal muscle are types of striated muscle." [CL:0000737, GOC:ef, GOC:mtg_muscle] is_a: GO:0033002 ! muscle cell proliferation intersection_of: GO:0008283 ! cell population proliferation intersection_of: RO:0012003 CL:0000737 ! acts on population of striated muscle cell relationship: RO:0012003 CL:0000737 ! acts on population of striated muscle cell property_value: RO:0002161 NCBITaxon:4751 [Term] id: GO:0014856 name: skeletal muscle cell proliferation namespace: biological_process def: "The multiplication or reproduction of skeletal muscle cells, resulting in the expansion of a cell population." [CL:0000188, GOC:ef, GOC:mtg_muscle] is_a: GO:0014855 ! striated muscle cell proliferation intersection_of: GO:0008283 ! cell population proliferation intersection_of: RO:0012003 CL:0000188 ! acts on population of cell of skeletal muscle relationship: RO:0012003 CL:0000188 ! acts on population of cell of skeletal muscle property_value: RO:0002161 NCBITaxon:4751 [Term] id: GO:0014857 name: regulation of skeletal muscle cell proliferation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of skeletal muscle cell proliferation." [CL:0000188, GOC:ef, GOC:mtg_muscle] is_a: GO:0042127 ! regulation of cell population proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0014856 ! regulates skeletal muscle cell proliferation relationship: RO:0002211 GO:0014856 ! regulates skeletal muscle cell proliferation property_value: RO:0002161 NCBITaxon:4751 [Term] id: GO:0014858 name: positive regulation of skeletal muscle cell proliferation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of skeletal muscle cell proliferation." [CL:0000188, GOC:ef, GOC:mtg_muscle] is_a: GO:0008284 ! positive regulation of cell population proliferation is_a: GO:0014857 ! regulation of skeletal muscle cell proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0014856 ! positively regulates skeletal muscle cell proliferation relationship: RO:0002213 GO:0014856 ! positively regulates skeletal muscle cell proliferation property_value: RO:0002161 NCBITaxon:4751 [Term] id: GO:0014859 name: negative regulation of skeletal muscle cell proliferation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of skeletal muscle cell proliferation." [CL:0000188, GOC:ef, GOC:mtg_muscle] is_a: GO:0008285 ! negative regulation of cell population proliferation is_a: GO:0014857 ! regulation of skeletal muscle cell proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0014856 ! negatively regulates skeletal muscle cell proliferation relationship: RO:0002212 GO:0014856 ! negatively regulates skeletal muscle cell proliferation property_value: RO:0002161 NCBITaxon:4751 [Term] id: GO:0014860 name: neurotransmitter secretion involved in regulation of skeletal muscle contraction namespace: biological_process def: "The regulated release of neurotransmitter into the synaptic cleft involved in skeletal muscle contraction. A neurotransmitter is any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell. Among the many substances that have the properties of a neurotransmitter are acetylcholine, noradrenaline, adrenaline, dopamine, glycine, gamma aminobutyrate, glutamic acid, substance P, enkephalins, endorphins and serotonin." [GOC:dph, GOC:mtg_muscle, GOC:tb] synonym: "neurotransmitter secretion involved in control of skeletal muscle contraction" EXACT [GOC:dph, GOC:tb] is_a: GO:0007269 ! neurotransmitter secretion intersection_of: GO:0007269 ! neurotransmitter secretion intersection_of: BFO:0000050 GO:0014819 ! part of regulation of skeletal muscle contraction relationship: BFO:0000050 GO:0014852 ! part of regulation of skeletal muscle contraction by neural stimulation via neuromuscular junction [Term] id: GO:0014861 name: regulation of skeletal muscle contraction via regulation of action potential namespace: biological_process def: "Any process that modulates the frequency, rate or extent of skeletal muscle contraction by depolarization of muscle membrane and ionic fluxes." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:mtg_muscle] synonym: "regulation of skeletal muscle contraction via membrane action potential" RELATED [] is_a: GO:0014819 ! regulation of skeletal muscle contraction is_a: GO:0098900 ! regulation of action potential intersection_of: GO:0050789 ! regulation of biological process intersection_of: RO:0002211 GO:0100001 ! regulates regulation of skeletal muscle contraction by action potential relationship: RO:0002211 GO:0100001 ! regulates regulation of skeletal muscle contraction by action potential [Term] id: GO:0014866 name: skeletal myofibril assembly namespace: biological_process def: "The process whose specific outcome is the progression of the skeletal myofibril over time, from its formation to the mature structure. A skeletal myofibril is a myofibril specific to skeletal muscle cells." [GOC:ef, GOC:mtg_muscle] is_a: GO:0030239 ! myofibril assembly intersection_of: GO:0022607 ! cellular component assembly intersection_of: RO:0002588 GO:0098723 ! results in assembly of skeletal muscle myofibril relationship: RO:0002588 GO:0098723 ! results in assembly of skeletal muscle myofibril [Term] id: GO:0014872 name: myoblast division namespace: biological_process def: "The process resulting in the physical partitioning and separation of a myoblast into daughter cells. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers." [CL:0000056, GOC:ef, GOC:mtg_muscle] is_a: BFO:0000003 is_a: GO:0051301 ! cell division intersection_of: GO:0051301 ! cell division intersection_of: RO:0004009 CL:0000056 ! has primary input myoblast relationship: RO:0004009 CL:0000056 ! has primary input myoblast [Term] id: GO:0014874 name: response to stimulus involved in regulation of muscle adaptation namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. This occurs as part of the regulation of muscle adaptation." [GOC:ef, GOC:mtg_muscle] synonym: "response to stimulus involved in regulation of muscle plasticity" RELATED [] is_a: BFO:0000003 is_a: GO:0050896 ! response to stimulus intersection_of: GO:0050896 ! response to stimulus intersection_of: BFO:0000050 GO:0043502 ! part of regulation of muscle adaptation relationship: BFO:0000050 GO:0043502 ! part of regulation of muscle adaptation property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0014878 name: response to electrical stimulus involved in regulation of muscle adaptation namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an electrical stimulus. This process occurs as part of the regulation of muscle adaptation." [GOC:ef, GOC:mtg_muscle] synonym: "response to electrical stimulus involved in regulation of muscle plasticity" RELATED [] is_a: GO:0014874 ! response to stimulus involved in regulation of muscle adaptation is_a: GO:0051602 ! response to electrical stimulus intersection_of: GO:0051602 ! response to electrical stimulus intersection_of: BFO:0000050 GO:0043502 ! part of regulation of muscle adaptation property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0014879 name: detection of electrical stimulus involved in regulation of muscle adaptation namespace: biological_process def: "The series of events by which an electrical stimulus is received and converted into a molecular signal. This occurs as part of the regulation of muscle adaptation." [GOC:ef, GOC:mtg_muscle] is_a: GO:0014878 ! response to electrical stimulus involved in regulation of muscle adaptation is_a: GO:0050981 ! detection of electrical stimulus intersection_of: GO:0050981 ! detection of electrical stimulus intersection_of: BFO:0000050 GO:0043502 ! part of regulation of muscle adaptation property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0014887 name: cardiac muscle adaptation namespace: biological_process def: "The process in which cardiac muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors." [GOC:mtg_muscle] synonym: "cardiac muscle plasticity" RELATED [] is_a: GO:0014888 ! striated muscle adaptation intersection_of: GO:0043500 ! muscle adaptation intersection_of: BFO:0000066 UBERON:0001133 ! occurs in cardiac muscle tissue relationship: BFO:0000066 UBERON:0001133 ! occurs in cardiac muscle tissue property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0014888 name: striated muscle adaptation namespace: biological_process def: "Any process in which striated muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors. These adaptive events occur in both muscle fibers and associated structures (motoneurons and capillaries), and they involve alterations in regulatory mechanisms, contractile properties and metabolic capacities." [GOC:mtg_muscle] synonym: "striated muscle plasticity" RELATED [] is_a: GO:0043500 ! muscle adaptation intersection_of: GO:0043500 ! muscle adaptation intersection_of: BFO:0000066 UBERON:0002036 ! occurs in striated muscle tissue relationship: BFO:0000066 UBERON:0002036 ! occurs in striated muscle tissue property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0014895 name: smooth muscle hypertrophy namespace: biological_process def: "The enlargement or overgrowth of all or part of an organ due to an increase in size of its smooth muscle cells without cell division. Physiological hypertrophy is a normal process during development, and can also occur in mature structures on demand. In the uterus, smooth muscle cells undergo hypertrophy during pregnancy." [GOC:mtg_muscle] is_a: GO:0014805 ! smooth muscle adaptation is_a: GO:0014896 ! muscle hypertrophy intersection_of: GO:0014896 ! muscle hypertrophy intersection_of: BFO:0000066 UBERON:0001135 ! occurs in smooth muscle tissue property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0014896 name: muscle hypertrophy namespace: biological_process def: "The muscle system process that results in enlargement or overgrowth of all or part of a muscle organ due to an increase in the size of its muscle cells. Physiological hypertrophy is a normal process during development (it stops in cardiac muscle after adolescence) and can also be brought on in response to demand. In athletes cardiac and skeletal muscles undergo hypertrophy stimulated by increasing muscle activity on exercise. Smooth muscle cells in the uterus undergo hypertrophy during pregnancy." [GOC:mtg_muscle] xref: Wikipedia:Muscle_hypertrophy is_a: BFO:0000003 is_a: GO:0003012 ! muscle system process relationship: BFO:0000066 UBERON:0002385 ! occurs in muscle tissue property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0014897 name: striated muscle hypertrophy namespace: biological_process def: "The enlargement or overgrowth of all or part of an organ due to an increase in size of muscle cells without cell division. In the case of striated muscle, this happens due to the additional synthesis of sarcomeric proteins and assembly of myofibrils." [GOC:mtg_muscle] is_a: GO:0014896 ! muscle hypertrophy intersection_of: GO:0014896 ! muscle hypertrophy intersection_of: RO:0004009 UBERON:0002036 ! has primary input striated muscle tissue relationship: RO:0004009 UBERON:0002036 ! has primary input striated muscle tissue property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0014901 name: satellite cell activation involved in skeletal muscle regeneration namespace: biological_process def: "The process that initiates skeletal muscle satellite cell division by causing it to move from quiescence to the G1 stage of the cell cycle. The cell swells and there are a number of other small changes. The cells then start to divide. Following cell division the cells will differentiate. In adult muscle, satellite cells become activated to divide and differentiate in response to muscle damage." [GOC:mtg_muscle] is_a: GO:0014719 ! skeletal muscle satellite cell activation intersection_of: GO:0014719 ! skeletal muscle satellite cell activation intersection_of: BFO:0000050 GO:0043403 ! part of skeletal muscle tissue regeneration relationship: BFO:0000050 GO:0043403 ! part of skeletal muscle tissue regeneration [Term] id: GO:0014902 name: myotube differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a myotube cell. Myotube differentiation starts with myoblast fusion and the appearance of specific cell markers (this is the cell development step). Then individual myotubes can fuse to form bigger myotubes and start to contract. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate and fuse." [GOC:mtg_muscle] is_a: GO:0051146 ! striated muscle cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0002372 ! results in acquisition of features of myotube relationship: RO:0002315 CL:0002372 ! results in acquisition of features of myotube [Term] id: GO:0014904 name: myotube cell development namespace: biological_process def: "The process aimed at the progression of a myotube cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate and fuse." [GOC:mtg_muscle] is_a: GO:0055002 ! striated muscle cell development intersection_of: GO:0032502 ! developmental process intersection_of: RO:0002296 CL:0002372 ! results in development of myotube relationship: BFO:0000050 GO:0014902 ! part of myotube differentiation relationship: RO:0002296 CL:0002372 ! results in development of myotube [Term] id: GO:0014906 name: myotube cell development involved in skeletal muscle regeneration namespace: biological_process def: "The process aimed at the progression of a myotube cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. This occurs as part of the process of skeletal muscle regeneration. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate and fuse." [GOC:mtg_muscle] is_a: GO:0014904 ! myotube cell development intersection_of: GO:0014904 ! myotube cell development intersection_of: BFO:0000050 GO:0043403 ! part of skeletal muscle tissue regeneration relationship: BFO:0000050 GO:0014908 ! part of myotube differentiation involved in skeletal muscle regeneration [Term] id: GO:0014908 name: myotube differentiation involved in skeletal muscle regeneration namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a myotube cell. Myotube differentiation starts with myoblast fusion and the appearance of specific cell markers (this is the cell development step). Then individual myotubes can fuse to form bigger myotubes and start to contract. This process occurs as part of the process of skeletal muscle regeneration. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate and fuse." [GOC:mtg_muscle] is_a: GO:0014902 ! myotube differentiation intersection_of: GO:0014902 ! myotube differentiation intersection_of: BFO:0000050 GO:0043403 ! part of skeletal muscle tissue regeneration relationship: BFO:0000050 GO:0043403 ! part of skeletal muscle tissue regeneration [Term] id: GO:0014909 name: smooth muscle cell migration namespace: biological_process def: "The orderly movement of a smooth muscle cell from one site to another, often during the development of a multicellular organism." [CL:0000192, GOC:mtg_muscle] is_a: GO:0014812 ! muscle cell migration intersection_of: GO:0016477 ! cell migration intersection_of: RO:0002565 CL:0000192 ! results in movement of smooth muscle cell relationship: RO:0002565 CL:0000192 ! results in movement of smooth muscle cell property_value: RO:0002161 NCBITaxon:4890 [Term] id: GO:0014910 name: regulation of smooth muscle cell migration namespace: biological_process def: "Any process that modulates the frequency, rate or extent of smooth muscle cell migration." [CL:0000192, GOC:mtg_muscle] is_a: GO:0030334 ! regulation of cell migration intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0014909 ! regulates smooth muscle cell migration relationship: RO:0002211 GO:0014909 ! regulates smooth muscle cell migration property_value: RO:0002161 NCBITaxon:451864 [Term] id: GO:0014911 name: positive regulation of smooth muscle cell migration namespace: biological_process def: "Any process that activates, maintains or increases the frequency, rate or extent of smooth muscle cell migration." [CL:0000192, GOC:mtg_muscle] is_a: GO:0014910 ! regulation of smooth muscle cell migration is_a: GO:0030335 ! positive regulation of cell migration intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0014909 ! positively regulates smooth muscle cell migration relationship: RO:0002213 GO:0014909 ! positively regulates smooth muscle cell migration property_value: RO:0002161 NCBITaxon:451864 [Term] id: GO:0014912 name: negative regulation of smooth muscle cell migration namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of smooth muscle cell migration." [CL:0000192, GOC:mtg_muscle] is_a: GO:0014910 ! regulation of smooth muscle cell migration is_a: GO:0030336 ! negative regulation of cell migration intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0014909 ! negatively regulates smooth muscle cell migration relationship: RO:0002212 GO:0014909 ! negatively regulates smooth muscle cell migration property_value: RO:0002161 NCBITaxon:451864 [Term] id: GO:0015031 name: protein transport namespace: biological_process def: "The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] subset: goslim_chembl subset: goslim_pir subset: goslim_yeast synonym: "enzyme transport" NARROW [] is_a: GO:0008104 ! intracellular protein localization is_a: GO:0045184 ! establishment of protein localization is_a: GO:0071705 ! nitrogen compound transport intersection_of: GO:0006810 ! transport intersection_of: RO:0004009 PR:000000001 ! has primary input protein [Term] id: GO:0015075 name: monoatomic ion transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of an ion from one side of a membrane to the other." [GOC:dgf, GOC:mtg_transport, ISBN:0815340729] synonym: "ion transmembrane transporter activity" BROAD [] synonym: "ion transporter activity" EXACT [] is_a: GO:0022857 ! transmembrane transporter activity intersection_of: GO:0022857 ! transmembrane transporter activity intersection_of: RO:0004009 CHEBI:24867 ! has primary input relationship: BFO:0000050 GO:0034220 {source="GO_REF:0000090"} ! part of monoatomic ion transmembrane transport relationship: RO:0004009 CHEBI:24867 ! has primary input property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/24479" xsd:anyURI [Term] id: GO:0015078 name: proton transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of a proton from one side of a membrane to the other." [GOC:ai] synonym: "hydrogen ion transmembrane transporter activity" EXACT [] synonym: "proton transporter activity" EXACT [] xref: Reactome:R-HSA-1222516 "Intraphagosomal pH is lowered to 5 by V-ATPase" xref: Reactome:R-HSA-164834 "Enzyme-bound ATP is released" xref: Reactome:R-HSA-168313 "Virion-associated M2 protein mediated ion infusion" xref: Reactome:R-HSA-170026 "UCP1 imports a proton" xref: Reactome:R-HSA-74723 "Endosome acidification" xref: Reactome:R-HSA-917841 "Acidification of Tf:TfR1 containing endosome" xref: Reactome:R-HSA-9864415 "AAC1 imports a proton" is_a: GO:0008324 ! monoatomic cation transmembrane transporter activity intersection_of: GO:0005215 ! transporter activity intersection_of: RO:0002342 GO:0016020 ! results in transport across membrane intersection_of: RO:0004009 CHEBI:15378 ! has primary input relationship: BFO:0000050 GO:1902600 {source="GO_REF:0000090"} ! part of proton transmembrane transport relationship: RO:0004009 CHEBI:15378 ! has primary input [Term] id: GO:0015079 name: potassium ion transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of potassium ions (K+) from one side of a membrane to the other." [GOC:ai] synonym: "potassium transporter activity" EXACT [] synonym: "potassium uptake permease activity" RELATED [] synonym: "potassium uptake transmembrane transporter activity" RELATED [] is_a: GO:0046873 ! metal ion transmembrane transporter activity intersection_of: GO:0022857 ! transmembrane transporter activity intersection_of: RO:0004009 CHEBI:29103 ! has primary input relationship: BFO:0000050 GO:0071805 {source="GO_REF:0000090"} ! part of potassium ion transmembrane transport relationship: RO:0004009 CHEBI:29103 ! has primary input property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/27521" xsd:anyURI [Term] id: GO:0015081 name: sodium ion transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of sodium ions (Na+) from one side of a membrane to the other." [GOC:ai, GOC:BHF] synonym: "sodium transporter activity" EXACT [] is_a: GO:0046873 ! metal ion transmembrane transporter activity intersection_of: GO:0022857 ! transmembrane transporter activity intersection_of: RO:0004009 CHEBI:29101 ! has primary input relationship: BFO:0000050 GO:0035725 ! part of sodium ion transmembrane transport relationship: RO:0004009 CHEBI:29101 ! has primary input property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/24076" xsd:anyURI property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/27521" xsd:anyURI [Term] id: GO:0015085 name: calcium ion transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of calcium (Ca) ions from one side of a membrane to the other." [GOC:dgf] xref: MetaCyc:TRANS-RXN-144 xref: Reactome:R-HSA-2534359 "CatSper Channel Mediated Calcium Transport" is_a: GO:0046873 ! metal ion transmembrane transporter activity intersection_of: GO:0022857 ! transmembrane transporter activity intersection_of: RO:0004009 CHEBI:29108 ! has primary input relationship: BFO:0000050 GO:0070588 ! part of calcium ion transmembrane transport relationship: RO:0004009 CHEBI:29108 ! has primary input property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/26941" xsd:anyURI property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/27521" xsd:anyURI [Term] id: GO:0015106 name: bicarbonate transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of bicarbonate from one side of a membrane to the other. Bicarbonate is the hydrogencarbonate ion, HCO3-." [GOC:ai] synonym: "hydrogencarbonate transmembrane transporter activity" EXACT [] xref: Reactome:R-HSA-2752067 "BESTs transport cytosolic HCO3- to extracellular region" is_a: GO:0022857 ! transmembrane transporter activity intersection_of: GO:0022857 ! transmembrane transporter activity intersection_of: RO:0004009 CHEBI:17544 ! has primary input relationship: BFO:0000050 GO:0015701 ! part of bicarbonate transport relationship: RO:0004009 CHEBI:17544 ! has primary input property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/26780" xsd:anyURI property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/27521" xsd:anyURI [Term] id: GO:0015125 name: bile acid transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of bile acid from one side of a membrane to the other. Bile acids are any of a group of steroid carboxylic acids occurring in bile, where they are present as the sodium salts of their amides with glycine or taurine." [GOC:ai] xref: Reactome:R-HSA-194079 "SLCO1B3 transports ALB:(GCCA, TCCA) from extracellular region to cytosol" xref: Reactome:R-HSA-194083 "SLCO1B1 transports ALB:(GCCA,TCCA) from extracellular region to cytosol" xref: Reactome:R-HSA-194130 "Transport (influx) of bile salts and acids by OATP-A" xref: Reactome:R-HSA-5661184 "Defective SLCO1B1 does not transport BIL from extracellular region (blood) to cytosol (hepatocyte)" xref: Reactome:R-HSA-5661198 "Defective SLCO1B3 does not transport BIL from extracellular region (blood) to cytosol (hepatocyte)" xref: Reactome:R-HSA-9733964 "SLC51A:SLC51B transports bile salts from cytosol to extracellular region" is_a: GO:0008028 ! monocarboxylic acid transmembrane transporter activity is_a: GO:0170055 ! lipid transmembrane transporter activity intersection_of: GO:0022857 ! transmembrane transporter activity intersection_of: RO:0004009 CHEBI:3098 ! has primary input relationship: BFO:0000050 GO:0015721 ! part of bile acid and bile salt transport relationship: RO:0004009 CHEBI:3098 ! has primary input [Term] id: GO:0015144 name: carbohydrate transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of carbohydrate from one side of a membrane to the other." [GOC:jl, GOC:mtg_transport, ISBN:0815340729] synonym: "carbohydrate transporter activity" RELATED [] synonym: "sugar transporter" NARROW [] is_a: GO:0022857 ! transmembrane transporter activity intersection_of: GO:0022857 ! transmembrane transporter activity intersection_of: RO:0004009 CHEBI:16646 ! has primary input relationship: BFO:0000050 GO:0034219 {source="GO_REF:0000090"} ! part of carbohydrate transmembrane transport relationship: RO:0004009 CHEBI:16646 ! has primary input [Term] id: GO:0015145 name: monosaccharide transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of a monosaccharide from one side of a membrane to the other." [GOC:jl, GOC:mtg_transport, ISBN:0815340729] is_a: GO:0051119 ! sugar transmembrane transporter activity intersection_of: GO:0022857 ! transmembrane transporter activity intersection_of: RO:0004009 CHEBI:35381 ! has primary input relationship: BFO:0000050 GO:0015749 ! part of monosaccharide transmembrane transport relationship: RO:0004009 CHEBI:35381 ! has primary input [Term] id: GO:0015149 name: hexose transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of a hexose sugar, a monosaccharide with 6 carbon atoms, from one side of a membrane to the other." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] xref: Reactome:R-HSA-189242 "SLC2A2 tetramer transports Fru, Gal, Glc from cytosol to extracellular region" xref: Reactome:R-HSA-5638222 "Defective SLC2A2 does not transport Fru, Gal, Glc from cytosol to extracellular region" is_a: GO:0015145 ! monosaccharide transmembrane transporter activity intersection_of: GO:0022857 ! transmembrane transporter activity intersection_of: RO:0004009 CHEBI:18133 ! has primary input relationship: BFO:0000050 GO:0008645 {source="GO_REF:0000090"} ! part of hexose transmembrane transport relationship: RO:0004009 CHEBI:18133 ! has primary input [Term] id: GO:0015159 name: polysaccharide transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of polysaccharides from one side of a membrane to the other. A polysaccharide is a polymer of many (typically more than 10) monosaccharide residues linked glycosidically." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] xref: Reactome:R-HSA-9932121 "Unknown transporter exports CA to extracellular space" xref: Reactome:R-HSA-9932466 "Bcs complex exports pEtN-cellulose" is_a: GO:0015144 ! carbohydrate transmembrane transporter activity is_a: GO:0022884 ! macromolecule transmembrane transporter activity intersection_of: GO:0022857 ! transmembrane transporter activity intersection_of: RO:0004009 CHEBI:18154 ! has primary input relationship: BFO:0000050 GO:0015774 ! part of polysaccharide transport relationship: RO:0004009 CHEBI:18154 ! has primary input [Term] id: GO:0015171 name: amino acid transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of amino acids from one side of a membrane to the other. Amino acids are organic molecules that contain an amino group and a carboxyl group." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] synonym: "amino acid permease activity" EXACT [] synonym: "amino acid transporter activity" BROAD [] synonym: "amino acid/choline transmembrane transporter activity" NARROW [] synonym: "general amino acid permease activity" RELATED [] synonym: "hydroxy/aromatic amino acid permease activity" RELATED [] xref: Reactome:R-HSA-210439 "glutamate uptake by astrocytes" xref: Reactome:R-HSA-212642 "L-Glutamine transport into neurons" xref: Reactome:R-HSA-351987 "SLC6A6-mediated uptake of taurine and beta-alanine" xref: Reactome:R-HSA-352029 "SLC6A12 (BGT-1)-mediated uptake of GABA and betaine" xref: Reactome:R-HSA-352052 "SLC6A20 cotransports L-Pro, Na+ from the extracellular region to cytosol" xref: Reactome:R-HSA-352059 "SLC6A15-mediated amino acid uptake" xref: Reactome:R-HSA-352103 "SLC43A1 (LAT3)-mediated uptake of large neutral amino acids" xref: Reactome:R-HSA-352107 "SLC43A2 (LAT4)-mediated uptake of large neutral amino acids" xref: Reactome:R-HSA-352108 "SLC38A2 (ATA2)-mediated uptake of neutral amino acids" xref: Reactome:R-HSA-352119 "SLC38A1 (ATA1)-mediated uptake of neutral amino acids" xref: Reactome:R-HSA-352136 "SLC38A4 (ATA3)-mediated uptake of arginine and lysine" xref: Reactome:R-HSA-352158 "SLC16A10-mediated uptake of aromatic amino acids" xref: Reactome:R-HSA-352174 "SLC38A3-mediated uptake of glutamine, histidine, asparagine, and alanine" xref: Reactome:R-HSA-352182 "SLC38A5-mediated uptake of glutamine, histidine, asparagine, and serine" xref: Reactome:R-HSA-352191 "SLC7A8-mediated uptake of neutral amino acids" xref: Reactome:R-HSA-352347 "SLC1A4-mediated exchange of extracellular serine for cytosolic alanine, threonine, or cysteine" xref: Reactome:R-HSA-352354 "SLC1A4-mediated exchange of extracellular cysteine for cytosolic alanine, serine, or threonine" xref: Reactome:R-HSA-352364 "SLC1A4-mediated exchange of extracellular alanine for cytosolic serine, threonine, or cysteine" xref: Reactome:R-HSA-352371 "SLC1A4-mediated exchange of extracellular threonine for cytosolic alanine, serine, or cysteine" xref: Reactome:R-HSA-352379 "SLC1A5-mediated exchange of alanine and glutamine across the plasma membrane" xref: Reactome:R-HSA-352385 "SLC1A5-mediated exchange of glutamine and alanine across the plasma membrane" xref: Reactome:R-HSA-375405 "SLC36A2 cotransports Gly, L-Pro with H+ from extracellular region to cytosol" xref: Reactome:R-HSA-375417 "SLC36A1-mediated uptake of glycine, proline, and alanine" xref: Reactome:R-HSA-375473 "SLC6A19 cotransports neutral amino acids, Na+ from extracellular region to cytosol" xref: Reactome:R-HSA-375487 "SLC6A14 cotransports SLC6A14 ligands, Cl-, 2Na+ from extracellular region to cytosol" xref: Reactome:R-HSA-375768 "SLC7A2, isoform B (CAT-2B)-mediated uptake of cationic amino acids" xref: Reactome:R-HSA-375770 "SLC7A3 (CAT-3)-mediated uptake of cationic amino acids" xref: Reactome:R-HSA-375776 "SLC7A1 (CAT-1)-mediated uptake of cationic amino acids" xref: Reactome:R-HSA-375790 "SLC7A2, isoform A (CAT-2A)-mediated uptake of cationic amino acids" xref: Reactome:R-HSA-376200 "SLC7A10-mediated uptake of small neutral amino acids" xref: Reactome:R-HSA-378513 "SLC7A11-mediated exchange of extracellular cysteine and cytosolic glutamate" xref: Reactome:R-HSA-379415 "SLC7A7:SLC3A2 exchanges L-Arg for L-Leu, Na+ across the plasma membrane" xref: Reactome:R-HSA-379426 "SLC7A6 (y+LAT2)-mediated exchange of extracellular leucine for cytosolic arginine" xref: Reactome:R-HSA-379432 "SLC7A9:SLC3A1 exchanges L-Arg, CySS-, L-Lys for L-Leu" xref: Reactome:R-HSA-5653850 "Defective SLC36A2 does not cotransport Gly, L-Pro with H+ from extracellular region to cytosol" xref: Reactome:R-HSA-5655702 "Defective SLC3A1 (in SLC7A9:SLC3A1) does not exchange L-Arg, CySS-, L-Lys for L-Leu" xref: Reactome:R-HSA-5659674 "Variant SLC6A14 cotransports SLC6A14 ligands, Cl-, 2Na+ from extracellular region to cytosol" xref: Reactome:R-HSA-5659734 "Defective SLC6A19 does not cotransport neutral amino acids, Na+ from extracellular region to cytosol" xref: Reactome:R-HSA-5660694 "Variant SLC6A20 does not cotransport L-Pro, Na+ from extracellulare region to cytosol" xref: Reactome:R-HSA-5660890 "Defective SLC7A9 (in SLC7A9:SLC3A1) does not exchange L-Arg, CySS-, L-Lys for L-Leu" xref: Reactome:R-HSA-5660910 "Defective SLC7A7 does not exchange L-Arg for L-Leu, Na+ across the plasma membrane" xref: Reactome:R-HSA-888592 "Loading of GABA into clathrin sculpted GABA transport vesicle lumen" xref: Reactome:R-HSA-8952726 "SLC38A9 transports L-Arg from lysosomal lumen to cytosol" is_a: GO:0022857 ! transmembrane transporter activity intersection_of: GO:0022857 ! transmembrane transporter activity intersection_of: RO:0004009 CHEBI:35238 ! has primary input relationship: BFO:0000050 GO:0003333 {source="GO_REF:0000090"} ! part of amino acid transmembrane transport relationship: RO:0004009 CHEBI:35238 ! has primary input [Term] id: GO:0015172 name: acidic amino acid transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of acidic amino acids from one side of a membrane to the other. Acidic amino acids have side chains with a negative charge at pH 7.3." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] synonym: "acidic amino acid transporter activity" BROAD [] xref: Reactome:R-HSA-372448 "SLC25A12,13 exchange L-Glu and L-Asp" is_a: GO:0015171 ! amino acid transmembrane transporter activity relationship: BFO:0000050 GO:0015800 ! part of acidic amino acid transport [Term] id: GO:0015173 name: aromatic amino acid transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of aromatic amino acids from one side of a membrane to the other. Aromatic amino acids have an aromatic ring." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] synonym: "aromatic amino acid transporter activity" BROAD [] synonym: "hydroxy/aromatic amino acid permease activity" RELATED [] synonym: "valine/tyrosine/tryptophan permease activity" RELATED [] is_a: GO:0046943 ! carboxylic acid transmembrane transporter activity intersection_of: GO:0022857 ! transmembrane transporter activity intersection_of: RO:0004009 CHEBI:33856 ! has primary input relationship: BFO:0000050 GO:0015801 ! part of aromatic amino acid transport relationship: RO:0004009 CHEBI:33856 ! has primary input [Term] id: GO:0015174 name: basic amino acid transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of basic amino acids from one side of a membrane to the other. Basic amino acids have side chains with a positive charge at pH 7.3." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] synonym: "basic amino acid permease activity" EXACT [] synonym: "basic amino acid transporter activity" BROAD [] synonym: "cationic amino acid transmembrane transporter activity" RELATED [] xref: Reactome:R-HSA-8932851 "PQLC2 transports L-Arg,L-His,L-Lys from lysosomal lumen to cytosol" xref: Reactome:R-HSA-8959781 "SLC25A29 transports basic amino acids from cytosol to mitochondrial matrix" is_a: GO:0015171 ! amino acid transmembrane transporter activity relationship: BFO:0000050 GO:1990822 ! part of basic amino acid transmembrane transport [Term] id: GO:0015175 name: neutral L-amino acid transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of neutral L-amino acids from one side of a membrane to the other. Neutral amino acids have side chains with no charge at pH 7.3." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] synonym: "neutral amino acid transmembrane transporter activity" EXACT [] synonym: "neutral amino acid transporter activity" BROAD [] is_a: GO:0015171 ! amino acid transmembrane transporter activity relationship: BFO:0000050 GO:0015804 ! part of neutral amino acid transport [Term] id: GO:0015179 name: L-amino acid transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of an L-amino acid from one side of a membrane to the other. L-amino acids are the L-enantiomers of amino acids." [GOC:ai, GOC:jsg, GOC:mah, GOC:mtg_transport, ISBN:0815340729] synonym: "L-amino acid transporter activity" BROAD [] xref: Reactome:R-HSA-212614 "Glutamine transport from astrocytes" xref: Reactome:R-HSA-352232 "SLC7A5:SLC3A2 transports neutral amino acids from extracellular region to cytosol" is_a: GO:0015171 ! amino acid transmembrane transporter activity is_a: GO:0046943 ! carboxylic acid transmembrane transporter activity intersection_of: GO:0022857 ! transmembrane transporter activity intersection_of: RO:0004009 CHEBI:59869 ! has primary input relationship: BFO:0000050 GO:1902475 {source="GO_REF:0000090"} ! part of L-alpha-amino acid transmembrane transport relationship: RO:0004009 CHEBI:59869 ! has primary input [Term] id: GO:0015185 name: gamma-aminobutyric acid transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of gamma-aminobutyric acid from one side of a membrane to the other. Gamma-aminobutyric acid is 4-aminobutyrate (GABA)." [GOC:go_curators, GOC:mtg_transport, ISBN:0198506732, ISBN:0815340729] synonym: "4-aminobutanoate transporter activity" EXACT [] synonym: "4-aminobutyrate transporter activity" EXACT [] synonym: "betaine/GABA:sodium symporter activity" NARROW [] synonym: "GABA transporter activity" EXACT [] is_a: GO:0008028 ! monocarboxylic acid transmembrane transporter activity is_a: GO:0015171 ! amino acid transmembrane transporter activity intersection_of: GO:0022857 ! transmembrane transporter activity intersection_of: RO:0004009 CHEBI:59888 ! has primary input relationship: BFO:0000050 GO:0015812 ! part of gamma-aminobutyric acid transport relationship: RO:0004009 CHEBI:59888 ! has primary input [Term] id: GO:0015187 name: glycine transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of glycine from one side of a membrane to the other. Glycine is aminoethanoic acid." [GOC:ai] synonym: "glycine betaine/proline porter activity" NARROW [] synonym: "glycine transporter activity" BROAD [] synonym: "proline/glycine/betaine:hydrogen/sodium symporter activity" NARROW [] is_a: GO:0015175 ! neutral L-amino acid transmembrane transporter activity is_a: GO:0046943 ! carboxylic acid transmembrane transporter activity intersection_of: GO:0022857 ! transmembrane transporter activity intersection_of: RO:0004009 CHEBI:57305 ! has primary input relationship: BFO:0000050 GO:0015816 ! part of glycine transport relationship: RO:0004009 CHEBI:57305 ! has primary input [Term] id: GO:0015215 name: nucleotide transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate, from one side of a membrane to the other." [ISBN:0198506732] is_a: GO:0015605 ! organophosphate ester transmembrane transporter activity is_a: GO:0015932 ! nucleobase-containing compound transmembrane transporter activity intersection_of: GO:0022857 ! transmembrane transporter activity intersection_of: RO:0004009 CHEBI:36976 ! has primary input relationship: BFO:0000050 GO:1901679 {source="GO_REF:0000090"} ! part of nucleotide transmembrane transport relationship: RO:0004009 CHEBI:36976 ! has primary input [Term] id: GO:0015216 name: purine nucleotide transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of a purine nucleotide, any compound consisting of a purine nucleoside esterified with (ortho)phosphate, from one side of a membrane to the other." [GOC:ai] is_a: GO:0015215 ! nucleotide transmembrane transporter activity intersection_of: GO:0022857 ! transmembrane transporter activity intersection_of: RO:0004009 CHEBI:26395 ! has primary input relationship: BFO:0000050 GO:0015865 ! part of purine nucleotide transport relationship: RO:0004009 CHEBI:26395 ! has primary input [Term] id: GO:0015217 name: ADP transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of ADP, adenosine diphosphate, from one side of a membrane to the other." [GOC:ai] is_a: GO:0000295 ! adenine nucleotide transmembrane transporter activity is_a: GO:0005346 ! purine ribonucleotide transmembrane transporter activity intersection_of: GO:0022857 ! transmembrane transporter activity intersection_of: RO:0004009 CHEBI:456216 ! has primary input relationship: BFO:0000050 GO:0015866 ! part of ADP transport relationship: RO:0004009 CHEBI:456216 ! has primary input [Term] id: GO:0015245 name: fatty acid transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of fatty acids from one side of a membrane to the other. Fatty acids are aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis." [ISBN:0198506732] synonym: "fatty acid transporter activity" RELATED [] synonym: "fatty acyl transporter activity" EXACT [] synonym: "fatty-acyl group transporter activity" BROAD [] synonym: "peroxisomal fatty acyl transporter" NARROW [] xref: Reactome:R-HSA-5627891 "Defective SLC27A4 does not transport LCFAs from extracellular region to cytosol" xref: Reactome:R-HSA-879585 "SLC27A1,4,6 transport LCFAs from extracellular region to cytosol" xref: Reactome:R-HSA-9032315 "oxo-DHAs translocate from cytosol to extracellular region" xref: Reactome:R-HSA-9032323 "oxo-DPAn-3s translocate from cytosol to extracellular region" is_a: GO:0008028 ! monocarboxylic acid transmembrane transporter activity is_a: GO:0170055 ! lipid transmembrane transporter activity intersection_of: GO:0005215 ! transporter activity intersection_of: RO:0002342 GO:0016020 ! results in transport across membrane intersection_of: RO:0004009 CHEBI:28868 ! has primary input relationship: BFO:0000050 GO:0015908 ! part of fatty acid transport relationship: RO:0004009 CHEBI:28868 ! has primary input [Term] id: GO:0015250 name: water channel activity namespace: molecular_function def: "Enables the energy-independent facilitated diffusion of water through a transmembrane aqueous pore or channel." [GOC:mtg_transport, ISBN:0815340729] synonym: "aquaporin" NARROW [] xref: MetaCyc:TRANS-RXN-145 xref: Reactome:R-HSA-432010 "Aquaporin-1 passively transports water into cell" xref: Reactome:R-HSA-432054 "Aquaporin-1 passively transports water out of cell" xref: Reactome:R-HSA-432065 "p-S256-Aquaporin-2 passively transports water into cell" xref: Reactome:R-HSA-432067 "Aquaporin-4 passively transports water out of cell" xref: Reactome:R-HSA-445714 "Aquaporin-3 passively transports water out of cell" xref: Reactome:R-HSA-507868 "Aquaporins passively transport water into cells" xref: Reactome:R-HSA-507870 "Aquaporins passively transport water out of cells" xref: RHEA:29667 {source="skos:broadMatch"} is_a: GO:0005372 ! water transmembrane transporter activity is_a: GO:0015267 ! channel activity intersection_of: GO:0015267 ! channel activity intersection_of: RO:0004009 CHEBI:15377 ! has primary input property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/26941" xsd:anyURI property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/27521" xsd:anyURI [Term] id: GO:0015252 name: proton channel activity namespace: molecular_function def: "Enables the facilitated diffusion of a hydrogen ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:mtg_transport, GOC:pr, ISBN:0815340729] synonym: "hydrogen ion channel activity" EXACT [] xref: Reactome:R-HSA-9729542 "OTOP1 transports H+ from the extracellular region to the cytosol" xref: RHEA:34979 {source="skos:broadMatch"} is_a: GO:0005261 ! monoatomic cation channel activity is_a: GO:0015078 ! proton transmembrane transporter activity intersection_of: GO:0005216 ! monoatomic ion channel activity intersection_of: RO:0004009 CHEBI:15378 ! has primary input property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/27278" xsd:anyURI [Term] id: GO:0015267 name: channel activity namespace: molecular_function def: "Enables the energy-independent facilitated diffusion of a solute through a transmembrane aqueous pore or channel. Stereospecificity is not exhibited but this transport may be specific for a particular molecular species or class of molecules." [GOC:mtg_transport, ISBN:0815340729] synonym: "alpha-type channel activity" RELATED [] synonym: "channel-forming toxin activity" RELATED [] synonym: "channel/pore class transporter activity" EXACT [] synonym: "nonselective channel activity" EXACT [] synonym: "pore activity" BROAD [] synonym: "pore class transporter activity" RELATED [] synonym: "substrate-specific channel activity" RELATED [] xref: Reactome:R-HSA-3779381 "H2O2 diffuses from the mitochondrial matrix to the cytosol" xref: Reactome:R-HSA-8953430 "PXMP2 trimer transports glycolate from cytosol to peroxisomal matrix" xref: Reactome:R-HSA-9857649 "p-S373-GJA1:p-S-ITGA5:ITGB1 (p-S373-Connexin-43:p-S-Integrin alpha5:Integrin beta1) transports ATP from the cytosol to the extracellular region" xref: Reactome:R-HSA-9857682 "p-S373-GJA1:p-S-ITGA5:ITGB1 (p-S373-Connexin-43:p-S-Integrin alpha5:Integrin beta1) transports prostaglandin E2 (PGE2) from the cytosol to the extracellular region" xref: Reactome:R-HSA-9905999 "Pannexin1 (PANX1) channel in a complex with P2RX7 transports ATP from the cytosol to the extracellular region" xref: TC:1 is_a: GO:0022803 ! passive transmembrane transporter activity [Term] id: GO:0015269 name: calcium-activated potassium channel activity namespace: molecular_function def: "Enables the transmembrane transfer of a potassium cation by a channel that opens when a calcium cation has been bound by the channel complex or one of its constituent parts." [GOC:dph, GOC:mtg_transport] xref: Reactome:R-HSA-9663752 "KCNN2 transports K+ from the cytosol to the extracellular region" xref: Reactome:R-HSA-9667809 "KCNMA1:KCNMB1 transports potassium ions from the cytosol to the extracellular region" is_a: GO:0005227 ! calcium-activated cation channel activity is_a: GO:0005267 ! potassium channel activity intersection_of: GO:0022836 ! gated channel activity intersection_of: RO:0004009 CHEBI:29103 ! has primary input intersection_of: RO:0012001 CHEBI:29108 ! has small molecule activator property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/24605" xsd:anyURI [Term] id: GO:0015276 name: ligand-gated monoatomic ion channel activity namespace: molecular_function def: "Enables the transmembrane transfer of an ion by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729] synonym: "ionotropic receptor activity" NARROW [GOC:bf, GOC:sart] synonym: "ligand-gated ion channel activity" BROAD [] xref: Reactome:R-HSA-451310 "Activation of Edited Kainate receptors" xref: Reactome:R-HSA-451311 "Activation of Ca-permeable Kainate receptors" xref: Reactome:R-HSA-622325 "Activation of highly sodium permeable postsynaptic nicotinic acetylcholine receptors" xref: Reactome:R-HSA-622326 "Activation of highly calcium permeable nicotinic acetylcholine receptors" xref: Reactome:R-HSA-629595 "Activation of highly calcium permeable postsynaptic nicotinic acetylcholine receptors" is_a: GO:0005216 ! monoatomic ion channel activity is_a: GO:0022834 ! ligand-gated channel activity intersection_of: GO:0022836 ! gated channel activity intersection_of: RO:0004009 CHEBI:24867 ! has primary input intersection_of: RO:0012001 CHEBI:24431 ! has small molecule activator [Term] id: GO:0015277 name: kainate selective glutamate receptor activity namespace: molecular_function def: "An ionotropic glutamate receptor activity that exhibits fast gating by glutamate, acts by opening a cation channel permeable to sodium and potassium, and for which kainate is an agonist." [GOC:mah, PMID:10049997, PMID:8804111] comment: Note that this term represents an activity and not a gene product. Consider also annotating to the molecular function terms 'ionotropic glutamate receptor activity ; GO:0004970' and 'cation channel activity ; GO:0005261'. is_a: GO:0004970 ! glutamate-gated receptor activity is_a: GO:0005267 ! potassium channel activity is_a: GO:0015280 ! ligand-gated sodium channel activity intersection_of: GO:0022836 ! gated channel activity intersection_of: RO:0004009 CHEBI:29101 ! has primary input intersection_of: RO:0004009 CHEBI:29103 ! has primary input intersection_of: RO:0012001 CHEBI:14321 ! has small molecule activator [Term] id: GO:0015280 name: ligand-gated sodium channel activity namespace: molecular_function def: "Enables the transmembrane transfer of a sodium ion by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts." [GOC:mah] synonym: "acid-sensing ion channel activity" NARROW [GOC:fj] synonym: "epithelial sodium channel" NARROW [GOC:fj] xref: Reactome:R-HSA-2672334 "SCNN channels transport extracellular Na+ to cytosol" is_a: GO:0005272 ! sodium channel activity is_a: GO:0099094 ! ligand-gated monoatomic cation channel activity intersection_of: GO:0022836 ! gated channel activity intersection_of: RO:0004009 CHEBI:29101 ! has primary input intersection_of: RO:0012001 CHEBI:24431 ! has small molecule activator property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/28941" xsd:anyURI [Term] id: GO:0015291 name: secondary active transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of a solute from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy, not direct ATP coupling. Secondary active transporters include symporters and antiporters." [GOC:mtg_transport, ISBN:0198506732, ISBN:0815340729, PMID:10839820] synonym: "active transporter" BROAD [] synonym: "coupled carrier" EXACT [] synonym: "electrochemical potential-driven transporter activity" EXACT [] synonym: "energizer of outer membrane receptor-mediated transport activity" NARROW [] synonym: "galactose/glucose (methylgalactoside) porter activity" RELATED [] synonym: "heavy metal ion porter activity" NARROW [] synonym: "ion-gradient-driven energizer activity" NARROW [] synonym: "multidrug endosomal transmembrane transporter activity" NARROW [] synonym: "nitrite/nitrate porter activity" NARROW [] synonym: "porter activity" EXACT [] synonym: "porters" EXACT [] synonym: "secondary carrier-type facilitators" EXACT [] xref: TC:2.A is_a: GO:0022804 ! active transmembrane transporter activity [Term] id: GO:0015355 name: secondary active monocarboxylate transmembrane transporter activity namespace: molecular_function def: "Catalysis of the movement of a monocarboxylate, any compound containing a single carboxyl group (COOH or COO-), by uniport, symport or antiport across a membrane by a carrier-mediated mechanism." [GOC:bf, GOC:jl] synonym: "monocarboxylate porter activity" RELATED [] is_a: GO:0008028 ! monocarboxylic acid transmembrane transporter activity is_a: GO:0015291 ! secondary active transmembrane transporter activity intersection_of: GO:0015291 ! secondary active transmembrane transporter activity intersection_of: RO:0004009 CHEBI:25384 ! has primary input [Term] id: GO:0015464 name: acetylcholine receptor activity namespace: molecular_function def: "Combining with an acetylcholine receptor ligand and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:jl, GOC:signaling] comment: For nicotinic acetylcholine receptors that act as ion channels, instead use 'acetylcholine-gated cation channel activity ; GO:0022848'. is_a: GO:0004888 ! transmembrane signaling receptor activity is_a: GO:0098960 ! postsynaptic neurotransmitter receptor activity intersection_of: GO:0038023 ! signaling receptor activity intersection_of: RO:0004009 CHEBI:15355 ! has primary input relationship: BFO:0000050 GO:0007271 ! part of synaptic transmission, cholinergic relationship: BFO:0000051 GO:0042166 ! has part acetylcholine binding relationship: RO:0004009 CHEBI:15355 ! has primary input [Term] id: GO:0015605 name: organophosphate ester transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of organophosphate esters from one side of a membrane to the other. Organophosphate esters are small organic molecules containing phosphate ester bonds." [GOC:mcc] is_a: GO:0022857 ! transmembrane transporter activity intersection_of: GO:0022857 ! transmembrane transporter activity intersection_of: RO:0004009 CHEBI:25703 ! has primary input relationship: BFO:0000050 GO:0015748 ! part of organophosphate ester transport relationship: RO:0004009 CHEBI:25703 ! has primary input [Term] id: GO:0015629 name: actin cytoskeleton namespace: cellular_component def: "The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes." [GOC:jl, ISBN:0395825172, ISBN:0815316194] is_a: GO:0005856 ! cytoskeleton [Term] id: GO:0015630 name: microtubule cytoskeleton namespace: cellular_component def: "The part of the cytoskeleton (the internal framework of a cell) composed of microtubules and associated proteins." [GOC:jl, ISBN:0395825172] is_a: GO:0005856 ! cytoskeleton [Term] id: GO:0015631 name: tubulin binding namespace: molecular_function def: "Binding to monomeric or multimeric forms of tubulin, including microtubules." [GOC:clt] is_a: GO:0008092 ! cytoskeletal protein binding [Term] id: GO:0015636 name: short-chain fatty acid transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of short-chain fatty acids from one side of a membrane to the other. A short-chain fatty acid has an aliphatic tail containing fewer than 6 carbons." [GOC:mah] comment: While there is not universal consensus on the lengths of short-, medium-, long- and very-long-chain fatty acids, the GO uses the definitions in ChEBI (see CHEBI:26666, CHEBI:59554, CHEBI:15904 and CHEBI:27283). synonym: "short-chain fatty acid transporter activity" RELATED [] synonym: "short-chain fatty acid uptake transporter activity" RELATED [] is_a: GO:0015245 ! fatty acid transmembrane transporter activity intersection_of: GO:0005215 ! transporter activity intersection_of: RO:0002342 GO:0016020 ! results in transport across membrane intersection_of: RO:0004009 CHEBI:58951 ! has primary input relationship: BFO:0000050 GO:0015912 ! part of short-chain fatty acid transport relationship: RO:0004009 CHEBI:58951 ! has primary input property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/26445" xsd:anyURI [Term] id: GO:0015665 name: alcohol transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of an alcohol from one side of a membrane to the other. An alcohol is any carbon compound that contains a hydroxyl group." [ISBN:0198506732] xref: Reactome:R-HSA-192010 "5beta-cholestan-3alpha, 7alpha, 12alpha-triol is translocated from the cytosol to the mitochondrial matrix" xref: Reactome:R-HSA-193537 "5beta-cholestan-3alpha, 7alpha-diol is translocated from the cytosol to the mitochondrial matrix" xref: Reactome:R-HSA-193715 "5beta-cholestan-3alpha,7alpha,24(S)-triol is translocated from the cytosol to the mitochondrial matrix" xref: Reactome:R-HSA-193774 "5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol is translocated from the cytosol to the mitochondrial matrix" xref: Reactome:R-HSA-193808 "5beta-cholestan-3alpha,7alpha,27-triol is translocated from the cytosol to the mitochondrial matrix" xref: Reactome:R-HSA-193832 "5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol is translocated from the cytosol to the mitochondrial matrix" is_a: GO:0022857 ! transmembrane transporter activity intersection_of: GO:0022857 ! transmembrane transporter activity intersection_of: RO:0004009 CHEBI:30879 ! has primary input relationship: RO:0004009 CHEBI:30879 ! has primary input [Term] id: GO:0015669 name: gas transport namespace: biological_process def: "The directed movement of substances that are gaseous in normal living conditions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] subset: goslim_pir is_a: GO:0006810 ! transport [Term] id: GO:0015671 name: oxygen transport namespace: biological_process def: "The directed movement of oxygen (O2) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] xref: Reactome:R-HSA-8981607 "Intracellular oxygen transport" is_a: BFO:0000003 is_a: GO:0015669 ! gas transport intersection_of: GO:0006810 ! transport intersection_of: RO:0004009 CHEBI:15379 ! has primary input relationship: RO:0004009 CHEBI:15379 ! has primary input [Term] id: GO:0015695 name: organic cation transport namespace: biological_process def: "The directed movement of organic cations into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Organic cations are atoms or small molecules with a positive charge which contain carbon in covalent linkage." [GOC:ai] is_a: BFO:0000003 is_a: GO:0006810 ! transport intersection_of: GO:0006810 ! transport intersection_of: RO:0004009 CHEBI:25697 ! has primary input relationship: RO:0004009 CHEBI:25697 ! has primary input [Term] id: GO:0015698 name: inorganic anion transport namespace: biological_process def: "The directed movement of inorganic anions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Inorganic anions are atoms or small molecules with a negative charge which do not contain carbon in covalent linkage." [GOC:krc] is_a: BFO:0000003 is_a: GO:0006810 ! transport intersection_of: GO:0006810 ! transport intersection_of: RO:0004009 CHEBI:24834 ! has primary input relationship: RO:0004009 CHEBI:24834 ! has primary input [Term] id: GO:0015701 name: bicarbonate transport namespace: biological_process def: "The directed movement of bicarbonate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc] synonym: "hydrogencarbonate transport" EXACT [] xref: Reactome:R-HSA-1475029 "Reversible hydration of carbon dioxide" xref: Reactome:R-HSA-1480926 "O2/CO2 exchange in erythrocytes" xref: Reactome:R-HSA-425381 "Bicarbonate transporters" is_a: GO:0015711 ! organic anion transport intersection_of: GO:0006810 ! transport intersection_of: RO:0004009 CHEBI:17544 ! has primary input relationship: RO:0004009 CHEBI:17544 ! has primary input property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/26780" xsd:anyURI [Term] id: GO:0015711 name: organic anion transport namespace: biological_process def: "The directed movement of organic anions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Organic anions are atoms or small molecules with a negative charge which contain carbon in covalent linkage." [GOC:ai, GOC:krc] is_a: BFO:0000003 is_a: GO:0006810 ! transport intersection_of: GO:0006810 ! transport intersection_of: RO:0004009 CHEBI:25696 ! has primary input relationship: RO:0004009 CHEBI:25696 ! has primary input [Term] id: GO:0015718 name: monocarboxylic acid transport namespace: biological_process def: "The directed movement of monocarboxylic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc] is_a: GO:0046942 ! carboxylic acid transport intersection_of: GO:0006810 ! transport intersection_of: RO:0004009 CHEBI:35757 ! has primary input relationship: RO:0004009 CHEBI:35757 ! has primary input [Term] id: GO:0015721 name: bile acid and bile salt transport namespace: biological_process def: "The directed movement of bile acid and bile salts into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:dph, GOC:krc, PMID:12663868, PMID:14699511] synonym: "bile acid transport" NARROW [] synonym: "bile salt transport" NARROW [] xref: Reactome:R-HSA-159418 "Recycling of bile acids and salts" is_a: GO:0006869 ! lipid transport is_a: GO:0015718 ! monocarboxylic acid transport is_a: GO:0015850 ! organic hydroxy compound transport intersection_of: GO:0006810 ! transport intersection_of: RO:0004009 CHEBI:3098 ! has primary input relationship: RO:0004009 CHEBI:3098 ! has primary input [Term] id: GO:0015748 name: organophosphate ester transport namespace: biological_process def: "The directed movement of organophosphate esters into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Organophosphate esters are small organic molecules containing phosphate ester bonds." [GOC:mcc] is_a: BFO:0000003 is_a: GO:0006810 ! transport intersection_of: GO:0006810 ! transport intersection_of: RO:0004009 CHEBI:25703 ! has primary input relationship: RO:0004009 CHEBI:25703 ! has primary input [Term] id: GO:0015749 name: monosaccharide transmembrane transport namespace: biological_process def: "The process in which a monosaccharide is transported across a lipid bilayer, from one side of a membrane to the other. Monosaccharides are the simplest carbohydrates; they are polyhydric alcohols containing either an aldehyde or a keto group and between three to ten or more carbon atoms. They form the constitutional repeating units of oligo- and polysaccharides." [GO_REF:0000069, GOC:TermGenie, GOC:vw] synonym: "monosaccharide transport" RELATED [] is_a: GO:0034219 ! carbohydrate transmembrane transport intersection_of: GO:0055085 ! transmembrane transport intersection_of: RO:0004009 CHEBI:35381 ! has primary input relationship: RO:0004009 CHEBI:35381 ! has primary input creation_date: 2017-02-19T10:41:27Z [Term] id: GO:0015774 name: polysaccharide transport namespace: biological_process def: "The directed movement of polysaccharides into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A polysaccharide is a polymer of many (typically more than 10) monosaccharide residues linked glycosidically." [GOC:ai] is_a: GO:0008643 ! carbohydrate transport intersection_of: GO:0006810 ! transport intersection_of: RO:0004009 CHEBI:18154 ! has primary input relationship: BFO:0000050 GO:0033037 ! part of polysaccharide localization relationship: RO:0004009 CHEBI:18154 ! has primary input [Term] id: GO:0015800 name: acidic amino acid transport namespace: biological_process def: "The directed movement of acidic amino acids, amino acids with a pH below 7, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] is_a: GO:0006865 ! amino acid transport [Term] id: GO:0015801 name: aromatic amino acid transport namespace: biological_process def: "The directed movement of aromatic amino acids, amino acids with aromatic ring, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] is_a: GO:0046942 ! carboxylic acid transport is_a: GO:0071705 ! nitrogen compound transport intersection_of: GO:0006810 ! transport intersection_of: RO:0004009 CHEBI:33856 ! has primary input relationship: RO:0004009 CHEBI:33856 ! has primary input [Term] id: GO:0015802 name: basic amino acid transport namespace: biological_process def: "The directed movement of basic amino acids, amino acids with a pH above 7, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] is_a: GO:0006865 ! amino acid transport [Term] id: GO:0015804 name: neutral amino acid transport namespace: biological_process def: "The directed movement of neutral amino acids, amino acids with no net charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] is_a: GO:0006865 ! amino acid transport [Term] id: GO:0015807 name: L-amino acid transport namespace: biological_process def: "The directed movement of L-enantiomer amino acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai, GOC:jsg, GOC:mah] is_a: GO:0006865 ! amino acid transport is_a: GO:0046942 ! carboxylic acid transport is_a: GO:0071705 ! nitrogen compound transport intersection_of: GO:0006810 ! transport intersection_of: RO:0004009 CHEBI:59869 ! has primary input relationship: RO:0004009 CHEBI:59869 ! has primary input [Term] id: GO:0015812 name: gamma-aminobutyric acid transport namespace: biological_process def: "The directed movement of gamma-aminobutyric acid (GABA, 4-aminobutyrate), an amino acid which acts as a neurotransmitter in some organisms, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:go_curators, ISBN:0198506732] comment: See also the biological process term 'neurotransmitter transport ; GO:0006836'. synonym: "4-aminobutanoate transport" EXACT [] synonym: "4-aminobutyrate transport" EXACT [] synonym: "GABA transport" EXACT [] is_a: GO:0006865 ! amino acid transport is_a: GO:0046942 ! carboxylic acid transport is_a: GO:0071705 ! nitrogen compound transport intersection_of: GO:0006810 ! transport intersection_of: RO:0004009 CHEBI:59888 ! has primary input relationship: RO:0004009 CHEBI:59888 ! has primary input [Term] id: GO:0015813 name: L-glutamate transmembrane transport namespace: biological_process def: "The directed movement of L-glutamate across a membrane by means of some agent such as a transporter or a pore." [PMID:21307582] synonym: "L-glutamate transport" BROAD [] synonym: "mitochondrial aspartate/glutamate transport" RELATED [] is_a: GO:0051938 ! L-glutamate import is_a: GO:1902475 ! L-alpha-amino acid transmembrane transport intersection_of: GO:0015800 ! acidic amino acid transport intersection_of: RO:0002342 GO:0016020 ! results in transport across membrane intersection_of: RO:0004009 CHEBI:29985 ! has primary input [Term] id: GO:0015816 name: glycine transport namespace: biological_process def: "The directed movement of glycine, aminoethanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] is_a: GO:0015695 ! organic cation transport is_a: GO:0015804 ! neutral amino acid transport is_a: GO:0046942 ! carboxylic acid transport is_a: GO:0071705 ! nitrogen compound transport intersection_of: GO:0006810 ! transport intersection_of: RO:0004009 CHEBI:57305 ! has primary input relationship: RO:0004009 CHEBI:57305 ! has primary input [Term] id: GO:0015833 name: peptide transport namespace: biological_process def: "The directed movement of peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] subset: goslim_pir is_a: GO:0042886 ! amide transport intersection_of: GO:0006810 ! transport intersection_of: RO:0004009 CHEBI:60466 ! has primary input relationship: RO:0004009 CHEBI:60466 ! has primary input [Term] id: GO:0015837 name: amine transport namespace: biological_process def: "The directed movement of amines, including polyamines, organic compounds containing one or more amino groups, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai, ISBN:0198506732] subset: goslim_pir synonym: "amine/polyamine transport" RELATED [] is_a: GO:0071705 ! nitrogen compound transport intersection_of: GO:0006810 ! transport intersection_of: RO:0004009 CHEBI:32952 ! has primary input relationship: RO:0004009 CHEBI:32952 ! has primary input [Term] id: GO:0015844 name: monoamine transport namespace: biological_process def: "The directed movement of monoamines, organic compounds that contain one amino group that is connected to an aromatic ring by an ethylene group (-CH2-CH2-), into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah] is_a: GO:0071705 ! nitrogen compound transport intersection_of: GO:0006810 ! transport intersection_of: RO:0004009 CHEBI:63534 ! has primary input relationship: RO:0004009 CHEBI:63534 ! has primary input [Term] id: GO:0015849 name: organic acid transport namespace: biological_process def: "The directed movement of organic acids, any acidic compound containing carbon in covalent linkage, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [ISBN:0198506732] subset: goslim_pir is_a: BFO:0000003 is_a: GO:0006810 ! transport intersection_of: GO:0006810 ! transport intersection_of: RO:0004009 CHEBI:64709 ! has primary input relationship: RO:0004009 CHEBI:64709 ! has primary input [Term] id: GO:0015850 name: organic hydroxy compound transport namespace: biological_process def: "The directed movement of an organic hydroxy compound (organic alcohol) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. An organic hydroxy compound is an organic compound having at least one hydroxy group attached to a carbon atom." [GOC:ai] synonym: "organic alcohol transport" EXACT [] is_a: BFO:0000003 is_a: GO:0006810 ! transport intersection_of: GO:0006810 ! transport intersection_of: RO:0004009 CHEBI:33822 ! has primary input relationship: RO:0004009 CHEBI:33822 ! has primary input [Term] id: GO:0015865 name: purine nucleotide transport namespace: biological_process def: "The directed movement of a purine nucleotide, any compound consisting of a purine nucleoside esterified with (ortho)phosphate, into, out of or within a cell." [GOC:ai] is_a: GO:0006862 ! nucleotide transport intersection_of: GO:0006810 ! transport intersection_of: RO:0004009 CHEBI:26395 ! has primary input relationship: RO:0004009 CHEBI:26395 ! has primary input [Term] id: GO:0015866 name: ADP transport namespace: biological_process def: "The directed movement of ADP, adenosine diphosphate, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] is_a: GO:0015711 ! organic anion transport is_a: GO:0015868 ! purine ribonucleotide transport is_a: GO:0051503 ! adenine nucleotide transport intersection_of: GO:0006810 ! transport intersection_of: RO:0004009 CHEBI:456216 ! has primary input relationship: RO:0004009 CHEBI:456216 ! has primary input [Term] id: GO:0015867 name: ATP transport namespace: biological_process def: "The directed movement of ATP, adenosine triphosphate, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] is_a: GO:0015711 ! organic anion transport is_a: GO:0015868 ! purine ribonucleotide transport is_a: GO:0051503 ! adenine nucleotide transport intersection_of: GO:0006810 ! transport intersection_of: RO:0004009 CHEBI:30616 ! has primary input relationship: RO:0004009 CHEBI:30616 ! has primary input [Term] id: GO:0015868 name: purine ribonucleotide transport namespace: biological_process def: "The directed movement of a purine ribonucleotide, any compound consisting of a purine ribonucleoside (a purine organic base attached to a ribose sugar) esterified with (ortho)phosphate, into, out of or within a cell." [GOC:ai] is_a: GO:0015865 ! purine nucleotide transport is_a: GO:1901264 ! carbohydrate derivative transport intersection_of: GO:0006810 ! transport intersection_of: RO:0004009 CHEBI:26400 ! has primary input relationship: RO:0004009 CHEBI:26400 ! has primary input [Term] id: GO:0015870 name: acetylcholine transport namespace: biological_process def: "The directed movement of acetylcholine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Acetylcholine is an acetic acid ester of the organic base choline and functions as a neurotransmitter, released at the synapses of parasympathetic nerves and at neuromuscular junctions." [GOC:ai] is_a: GO:0015695 ! organic cation transport is_a: GO:0071705 ! nitrogen compound transport is_a: GO:1901374 ! acetate ester transport intersection_of: GO:0006810 ! transport intersection_of: RO:0004009 CHEBI:15355 ! has primary input relationship: RO:0004009 CHEBI:15355 ! has primary input [Term] id: GO:0015872 name: dopamine transport namespace: biological_process def: "The directed movement of dopamine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Dopamine is a catecholamine neurotransmitter and a metabolic precursor of noradrenaline and adrenaline." [GOC:ai] is_a: GO:0051937 ! catecholamine transport intersection_of: GO:0006810 ! transport intersection_of: RO:0004009 CHEBI:59905 ! has primary input relationship: RO:0004009 CHEBI:59905 ! has primary input [Term] id: GO:0015874 name: norepinephrine transport namespace: biological_process def: "The directed movement of norepinephrine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Norepinephrine (3,4-dihydroxyphenyl-2-aminoethanol) is a hormone secreted by the adrenal medulla and a neurotransmitter in the sympathetic peripheral nervous system and in some tracts of the CNS. It is also the biosynthetic precursor of epinephrine." [GOC:ai, ISBN:0198506732] synonym: "levarterenol transport" EXACT [] synonym: "noradrenaline transport" EXACT [] is_a: GO:0015695 ! organic cation transport is_a: GO:0051937 ! catecholamine transport intersection_of: GO:0006810 ! transport intersection_of: RO:0004009 CHEBI:72587 ! has primary input relationship: RO:0004009 CHEBI:72587 ! has primary input [Term] id: GO:0015908 name: fatty acid transport namespace: biological_process def: "The directed movement of fatty acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Fatty acids are aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis." [GOC:ai] is_a: GO:0006869 ! lipid transport is_a: GO:0015718 ! monocarboxylic acid transport intersection_of: GO:0006810 ! transport intersection_of: RO:0004009 CHEBI:28868 ! has primary input relationship: RO:0004009 CHEBI:28868 ! has primary input [Term] id: GO:0015912 name: short-chain fatty acid transport namespace: biological_process def: "The directed movement of short-chain fatty acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A short-chain fatty acid has an aliphatic tail containing fewer than 6 carbons." [GOC:ai] comment: While there is not universal consensus on the lengths of short-, medium-, long- and very-long-chain fatty acids, the GO uses the definitions in ChEBI (see CHEBI:26666, CHEBI:59554, CHEBI:15904 and CHEBI:27283). is_a: GO:0015908 ! fatty acid transport intersection_of: GO:0006810 ! transport intersection_of: RO:0004009 CHEBI:58951 ! has primary input relationship: RO:0004009 CHEBI:58951 ! has primary input property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/26445" xsd:anyURI [Term] id: GO:0015913 name: short-chain fatty acid transmembrane transport namespace: biological_process def: "The directed movement of short-chain fatty acids into a cell or organelle. A short-chain fatty acid has an aliphatic tail containing fewer than 6 carbons." [GOC:ai] comment: While there is not universal consensus on the lengths of short-, medium-, long- and very-long-chain fatty acids, the GO uses the definitions in ChEBI (see CHEBI:26666, CHEBI:59554, CHEBI:15904 and CHEBI:27283). synonym: "short-chain fatty acid import" RELATED [] synonym: "short-chain fatty acid uptake" EXACT [] is_a: GO:0015912 ! short-chain fatty acid transport is_a: GO:1902001 ! fatty acid transmembrane transport intersection_of: GO:0055085 ! transmembrane transport intersection_of: RO:0004009 CHEBI:58951 ! has primary input property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/24587" xsd:anyURI property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/26445" xsd:anyURI [Term] id: GO:0015931 name: nucleobase-containing compound transport namespace: biological_process def: "The directed movement of nucleobases, nucleosides, nucleotides and nucleic acids, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] subset: goslim_pir subset: goslim_yeast synonym: "nucleobase, nucleoside, nucleotide and nucleic acid transport" RELATED [GOC:dph, GOC:tb] is_a: GO:0071705 ! nitrogen compound transport intersection_of: GO:0006810 ! transport intersection_of: RO:0004009 CHEBI:61120 ! has primary input relationship: RO:0004009 CHEBI:61120 ! has primary input [Term] id: GO:0015932 name: nucleobase-containing compound transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of nucleobases, nucleosides, nucleotides and nucleic acids from one side of a membrane to the other." [GOC:ai] synonym: "nucleobase, nucleoside, nucleotide and nucleic acid transmembrane transporter activity" RELATED [GOC:dph, GOC:tb] is_a: GO:0022857 ! transmembrane transporter activity intersection_of: GO:0022857 ! transmembrane transporter activity intersection_of: RO:0004009 CHEBI:61120 ! has primary input relationship: BFO:0000050 GO:0015931 ! part of nucleobase-containing compound transport relationship: RO:0004009 CHEBI:61120 ! has primary input [Term] id: GO:0015979 name: photosynthesis namespace: biological_process def: "The synthesis by organisms of organic chemical compounds, especially carbohydrates, from carbon dioxide (CO2) using energy obtained from light rather than from the oxidation of chemical compounds." [ISBN:0198547684] subset: goslim_chembl subset: goslim_generic subset: goslim_metagenomics subset: goslim_pir subset: goslim_plant subset: goslim_plant_ribbon subset: goslim_prokaryote subset: goslim_prokaryote_ribbon xref: Wikipedia:Photosynthesis is_a: GO:0008152 ! metabolic process property_value: RO:0002161 NCBITaxon:33208 property_value: RO:0002161 NCBITaxon:4895 [Term] id: GO:0015980 name: energy derivation by oxidation of organic compounds namespace: biological_process def: "The chemical reactions and pathways by which a cell derives energy from organic compounds; results in the oxidation of the compounds from which energy is released." [GOC:mah] synonym: "chemoorganotrophy" EXACT [] is_a: GO:0006091 ! generation of precursor metabolites and energy [Term] id: GO:0016020 name: membrane namespace: cellular_component def: "A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] subset: goslim_candida subset: goslim_chembl subset: goslim_flybase_ribbon subset: goslim_metagenomics subset: goslim_pir subset: goslim_plant subset: goslim_yeast synonym: "integral component of membrane" NARROW [] synonym: "integral to membrane" NARROW [] synonym: "membrane region" NARROW [] synonym: "region of membrane" NARROW [] synonym: "transmembrane" RELATED [GOC:mah] synonym: "whole membrane" NARROW [] xref: Wikipedia:Biological_membrane xref: Wikipedia:Transmembrane_protein is_a: GO:0110165 ! cellular anatomical structure disjoint_from: GO:0031012 ! extracellular matrix property_value: skos:prefLabel "membrane" xsd:string creation_date: 2014-03-06T11:37:54Z [Term] id: GO:0016031 name: tRNA import into mitochondrion namespace: biological_process def: "The process in which a tRNA is transported from the cytosol into the mitochondrial matrix." [GOC:ma, PMID:10988073, PMID:11121736] synonym: "cytoplasmic tRNA import into mitochondria" EXACT [] synonym: "cytoplasmic tRNA import into mitochondrion" NARROW [GOC:bf] synonym: "cytoplasmic tRNA transport into mitochondrion" EXACT [] synonym: "cytoplasmic tRNA, mitochondrial import" EXACT [] synonym: "mitochondrial import of cytoplasmic tRNA" NARROW [] synonym: "nuclear-encoded tRNA import into mitochondrion" NARROW [GOC:bf] is_a: GO:0035927 ! RNA import into mitochondrion is_a: GO:0051031 ! tRNA transport intersection_of: GO:0006810 ! transport intersection_of: RO:0002338 GO:0005829 ! has target start location cytosol intersection_of: RO:0002339 GO:0005759 ! has target end location mitochondrial matrix intersection_of: RO:0002342 GO:0031966 ! results in transport across mitochondrial membrane intersection_of: RO:0004009 CHEBI:17843 ! has primary input [Term] id: GO:0016042 name: lipid catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent." [GOC:go_curators] synonym: "lipid breakdown" EXACT [] synonym: "lipid catabolism" EXACT [] synonym: "lipid degradation" EXACT [] synonym: "lipolysis" EXACT [] synonym: "multicellular organism lipid catabolic process" NARROW [] synonym: "multicellular organismal lipid catabolic process" NARROW [] xref: Wikipedia:Lipid_catabolism is_a: GO:0006629 ! lipid metabolic process is_a: GO:0009056 ! catabolic process intersection_of: GO:0009056 ! catabolic process intersection_of: RO:0004009 CHEBI:18059 ! has primary input relationship: RO:0004009 CHEBI:18059 ! has primary input [Term] id: GO:0016043 name: cellular component organization namespace: biological_process def: "A process that results in the assembly, arrangement of constituent parts, or disassembly of a cellular component." [GOC:ai, GOC:jl, GOC:mah] subset: gocheck_do_not_annotate subset: goslim_agr subset: goslim_mouse subset: goslim_pir subset: goslim_plant subset: goslim_plant_ribbon synonym: "cell organisation" EXACT [] synonym: "cell organization and biogenesis" RELATED [GOC:mah] synonym: "cellular component organisation at cellular level" EXACT [GOC:mah] synonym: "cellular component organisation in other organism" EXACT [GOC:mah] synonym: "cellular component organization at cellular level" EXACT [] synonym: "cellular component organization in other organism" EXACT [] is_a: BFO:0000003 is_a: GO:0071840 ! cellular component organization or biogenesis intersection_of: GO:0009987 ! cellular process intersection_of: RO:0002592 GO:0005575 ! results in organization of cellular_component relationship: RO:0002592 GO:0005575 ! results in organization of cellular_component [Term] id: GO:0016048 name: detection of temperature stimulus namespace: biological_process def: "The series of events in which a temperature stimulus (hot or cold) is received and converted into a molecular signal." [GOC:hb] synonym: "detection of temperature" EXACT [] synonym: "detection of thermal stimulus" EXACT [] synonym: "perception of temperature" RELATED [] is_a: GO:0009266 ! response to temperature stimulus is_a: GO:0009581 ! detection of external stimulus is_a: GO:0009582 ! detection of abiotic stimulus [Term] id: GO:0016049 name: cell growth namespace: biological_process def: "The process in which a cell irreversibly increases in size over time by accretion and biosynthetic production of matter similar to that already present." [GOC:ai] subset: gocheck_do_not_annotate subset: goslim_drosophila subset: goslim_pir subset: goslim_plant synonym: "cell expansion" RELATED [] synonym: "cellular growth" EXACT [] synonym: "growth of cell" EXACT [] synonym: "metabolic process resulting in cell growth" RELATED [] synonym: "metabolism resulting in cell growth" RELATED [] synonym: "non-developmental cell growth" RELATED [GOC:mah] synonym: "non-developmental growth of a unicellular organism" RELATED [GOC:mah] is_a: BFO:0000003 is_a: GO:0009987 ! cellular process is_a: GO:0040007 ! growth intersection_of: GO:0040007 ! growth intersection_of: RO:0002343 CL:0000000 ! results in growth of cell relationship: RO:0002343 CL:0000000 ! results in growth of cell [Term] id: GO:0016050 name: vesicle organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a vesicle." [GOC:mah] subset: goslim_pir subset: goslim_yeast synonym: "vesicle organisation" EXACT [] synonym: "vesicle organization and biogenesis" RELATED [GOC:mah] is_a: GO:0006996 ! organelle organization intersection_of: GO:0016043 ! cellular component organization intersection_of: RO:0002592 GO:0031982 ! results in organization of vesicle relationship: RO:0002592 GO:0031982 ! results in organization of vesicle [Term] id: GO:0016051 name: carbohydrate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [ISBN:0198506732] synonym: "anabolic carbohydrate metabolic process" EXACT [] synonym: "anabolic carbohydrate metabolism" EXACT [] synonym: "carbohydrate anabolism" EXACT [] synonym: "carbohydrate biosynthesis" EXACT [] synonym: "carbohydrate formation" EXACT [] synonym: "carbohydrate synthesis" EXACT [] is_a: GO:0005975 ! carbohydrate metabolic process is_a: GO:0009058 ! biosynthetic process intersection_of: GO:0009058 ! biosynthetic process intersection_of: RO:0004008 CHEBI:16646 ! has primary output relationship: RO:0004008 CHEBI:16646 ! has primary output [Term] id: GO:0016052 name: carbohydrate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [ISBN:0198506732] synonym: "carbohydrate breakdown" EXACT [] synonym: "carbohydrate catabolism" EXACT [] synonym: "carbohydrate degradation" EXACT [] synonym: "catabolic carbohydrate metabolic process" EXACT [] synonym: "catabolic carbohydrate metabolism" EXACT [] synonym: "multicellular organismal carbohydrate catabolic process" NARROW [] synonym: "single-organism carbohydrate catabolic process" RELATED [] is_a: GO:0005975 ! carbohydrate metabolic process is_a: GO:0009056 ! catabolic process intersection_of: GO:0009056 ! catabolic process intersection_of: RO:0004009 CHEBI:16646 ! has primary input relationship: RO:0004009 CHEBI:16646 ! has primary input creation_date: 2012-10-23T16:34:39Z [Term] id: GO:0016053 name: organic acid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of organic acids, any acidic compound containing carbon in covalent linkage." [ISBN:0198506732] synonym: "organic acid anabolism" EXACT [] synonym: "organic acid biosynthesis" EXACT [] synonym: "organic acid formation" EXACT [] synonym: "organic acid synthesis" EXACT [] is_a: GO:0006082 ! organic acid metabolic process is_a: GO:0044283 ! small molecule biosynthetic process intersection_of: GO:0009058 ! biosynthetic process intersection_of: RO:0004008 CHEBI:64709 ! has primary output relationship: RO:0004008 CHEBI:64709 ! has primary output [Term] id: GO:0016054 name: organic acid catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of organic acids, any acidic compound containing carbon in covalent linkage." [ISBN:0198506732] synonym: "organic acid breakdown" EXACT [] synonym: "organic acid catabolism" EXACT [] synonym: "organic acid degradation" EXACT [] is_a: GO:0006082 ! organic acid metabolic process is_a: GO:0044282 ! small molecule catabolic process intersection_of: GO:0009056 ! catabolic process intersection_of: RO:0004009 CHEBI:64709 ! has primary input relationship: RO:0004009 CHEBI:64709 ! has primary input [Term] id: GO:0016057 name: regulation of membrane potential in photoreceptor cell namespace: biological_process def: "Hyperpolarization (vertebrates) or depolarization (invertebrates) of the photoreceptor cell membrane via closing/opening of cation specific channels as a result of signals generated by rhodopsin activation by a photon." [GOC:dph, GOC:hb, GOC:tb] synonym: "changes in polarization state of photoreceptor cell membrane" EXACT [GOC:dph, GOC:tb] is_a: GO:0042391 ! regulation of membrane potential intersection_of: GO:0042391 ! regulation of membrane potential intersection_of: BFO:0000066 CL:0000210 ! occurs in photoreceptor cell relationship: BFO:0000066 CL:0000210 ! occurs in photoreceptor cell [Term] id: GO:0016064 name: immunoglobulin mediated immune response namespace: biological_process def: "An immune response mediated by immunoglobulins, whether cell-bound or in solution." [GO_REF:0000022, GOC:add, ISBN:0781735149] synonym: "antibody-mediated immune response" EXACT [] is_a: GO:0019724 ! B cell mediated immunity [Term] id: GO:0016070 name: RNA metabolic process namespace: biological_process def: "The cellular chemical reactions and pathways involving RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage." [ISBN:0198506732] subset: goslim_agr subset: goslim_candida subset: goslim_euk_cellular_processes_ribbon subset: goslim_metagenomics subset: goslim_pir subset: goslim_prokaryote synonym: "RNA metabolism" EXACT [] xref: Reactome:R-HSA-8953854 "Metabolism of RNA" is_a: GO:0090304 ! nucleic acid metabolic process intersection_of: GO:0008152 ! metabolic process intersection_of: RO:0004007 CHEBI:33697 ! has primary input or output relationship: RO:0004007 CHEBI:33697 ! has primary input or output [Term] id: GO:0016079 name: synaptic vesicle exocytosis namespace: biological_process def: "Fusion of intracellular membrane-bounded vesicles with the pre-synaptic membrane of the neuronal cell resulting in release of neurotransmitter into the synaptic cleft." [GOC:jid, GOC:lmg] subset: goslim_synapse is_a: GO:0045055 ! regulated exocytosis is_a: GO:0051649 ! establishment of localization in cell is_a: GO:0099003 ! vesicle-mediated transport in synapse is_a: GO:0099643 ! signal release from synapse intersection_of: GO:0045055 ! regulated exocytosis intersection_of: BFO:0000066 GO:0098793 ! occurs in presynapse relationship: BFO:0000050 GO:0007269 ! part of neurotransmitter secretion relationship: BFO:0000050 GO:0099504 ! part of synaptic vesicle cycle [Term] id: GO:0016106 name: sesquiterpenoid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of sesquiterpenoid compounds, terpenoids with three isoprene units." [GOC:go_curators] synonym: "sesquiterpenoid anabolism" EXACT [] synonym: "sesquiterpenoid biosynthesis" EXACT [] synonym: "sesquiterpenoid formation" EXACT [] synonym: "sesquiterpenoid synthesis" EXACT [] is_a: GO:0006714 ! sesquiterpenoid metabolic process is_a: GO:0016114 ! terpenoid biosynthetic process intersection_of: GO:0009058 ! biosynthetic process intersection_of: RO:0004008 CHEBI:26658 ! has primary output relationship: RO:0004008 CHEBI:26658 ! has primary output [Term] id: GO:0016107 name: sesquiterpenoid catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of sesquiterpenoid compounds, terpenoids with three isoprene units." [GOC:go_curators] synonym: "sesquiterpenoid breakdown" EXACT [] synonym: "sesquiterpenoid catabolism" EXACT [] synonym: "sesquiterpenoid degradation" EXACT [] is_a: GO:0006714 ! sesquiterpenoid metabolic process is_a: GO:0016115 ! terpenoid catabolic process intersection_of: GO:0009056 ! catabolic process intersection_of: RO:0004009 CHEBI:26658 ! has primary input relationship: RO:0004009 CHEBI:26658 ! has primary input [Term] id: GO:0016109 name: tetraterpenoid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of tetraterpenoid compounds, terpenoids with eight isoprene units." [GOC:go_curators] synonym: "tetraterpene biosynthesis" NARROW [] synonym: "tetraterpene biosynthetic process" NARROW [] synonym: "tetraterpenoid anabolism" EXACT [] synonym: "tetraterpenoid biosynthesis" EXACT [] synonym: "tetraterpenoid formation" EXACT [] synonym: "tetraterpenoid synthesis" EXACT [] is_a: GO:0016114 ! terpenoid biosynthetic process intersection_of: GO:0009058 ! biosynthetic process intersection_of: RO:0004008 CHEBI:26935 ! has primary output relationship: RO:0004008 CHEBI:26935 ! has primary output [Term] id: GO:0016110 name: tetraterpenoid catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of tetraterpenoid compounds, terpenoids with eight isoprene units." [GOC:go_curators] synonym: "tetraterpene catabolic process" NARROW [] synonym: "tetraterpene catabolism" NARROW [] synonym: "tetraterpenoid breakdown" EXACT [] synonym: "tetraterpenoid catabolism" EXACT [] synonym: "tetraterpenoid degradation" EXACT [] is_a: GO:0016115 ! terpenoid catabolic process intersection_of: GO:0009056 ! catabolic process intersection_of: RO:0004009 CHEBI:26935 ! has primary input relationship: RO:0004009 CHEBI:26935 ! has primary input [Term] id: GO:0016114 name: terpenoid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of terpenoids, any member of a class of compounds characterized by an isoprenoid chemical structure." [GOC:ai] synonym: "terpenoid anabolism" EXACT [] synonym: "terpenoid biosynthesis" EXACT [] synonym: "terpenoid formation" EXACT [] synonym: "terpenoid synthesis" EXACT [] xref: Wikipedia:Terpenoid is_a: GO:0006721 ! terpenoid metabolic process is_a: GO:0008299 ! isoprenoid biosynthetic process intersection_of: GO:0009058 ! biosynthetic process intersection_of: RO:0004008 CHEBI:26873 ! has primary output relationship: RO:0004008 CHEBI:26873 ! has primary output [Term] id: GO:0016115 name: terpenoid catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of terpenoids, any member of a class of compounds characterized by an isoprenoid chemical structure." [GOC:ai] synonym: "terpenoid breakdown" EXACT [] synonym: "terpenoid catabolism" EXACT [] synonym: "terpenoid degradation" EXACT [] is_a: GO:0006721 ! terpenoid metabolic process is_a: GO:0008300 ! isoprenoid catabolic process intersection_of: GO:0009056 ! catabolic process intersection_of: RO:0004009 CHEBI:26873 ! has primary input relationship: RO:0004009 CHEBI:26873 ! has primary input [Term] id: GO:0016116 name: carotenoid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving carotenoids, tetraterpenoid compounds in which two units of 4 isoprenoid residues joined head-to-tail are themselves joined tail-to-tail." [ISBN:0198547684] synonym: "carotenoid metabolism" EXACT [] is_a: GO:0006721 ! terpenoid metabolic process intersection_of: GO:0008152 ! metabolic process intersection_of: RO:0004007 CHEBI:23044 ! has primary input or output relationship: RO:0004007 CHEBI:23044 ! has primary input or output property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0016117 name: carotenoid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of carotenoids, tetraterpenoid compounds in which two units of 4 isoprenoid residues joined head-to-tail are themselves joined tail-to-tail." [GOC:go_curators] synonym: "carotenoid anabolism" EXACT [] synonym: "carotenoid biosynthesis" EXACT [] synonym: "carotenoid formation" EXACT [] synonym: "carotenoid synthesis" EXACT [] xref: MetaCyc:CAROTENOID-PWY is_a: GO:0016109 ! tetraterpenoid biosynthetic process is_a: GO:0016116 ! carotenoid metabolic process is_a: GO:0046148 ! pigment biosynthetic process intersection_of: GO:0009058 ! biosynthetic process intersection_of: RO:0004008 CHEBI:23044 ! has primary output relationship: RO:0004008 CHEBI:23044 ! has primary output property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0016118 name: carotenoid catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of carotenoids, tetraterpenoid compounds in which two units of 4 isoprenoid residues joined head-to-tail are themselves joined tail-to-tail." [GOC:go_curators] synonym: "carotenoid breakdown" EXACT [] synonym: "carotenoid catabolism" EXACT [] synonym: "carotenoid degradation" EXACT [] is_a: GO:0016110 ! tetraterpenoid catabolic process is_a: GO:0016116 ! carotenoid metabolic process intersection_of: GO:0009056 ! catabolic process intersection_of: RO:0004009 CHEBI:23044 ! has primary input relationship: RO:0004009 CHEBI:23044 ! has primary input property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0016122 name: xanthophyll metabolic process namespace: biological_process def: "The chemical reactions and pathways involving xanthophylls, oxygen-containing carotenoids." [ISBN:0198547684] synonym: "xanthophyll metabolism" EXACT [] is_a: GO:0016116 ! carotenoid metabolic process intersection_of: GO:0008152 ! metabolic process intersection_of: RO:0004007 CHEBI:27325 ! has primary input or output relationship: RO:0004007 CHEBI:27325 ! has primary input or output property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0016123 name: xanthophyll biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of xanthophylls, oxygen-containing carotenoids." [GOC:go_curators] synonym: "xanthophyll anabolism" EXACT [] synonym: "xanthophyll biosynthesis" EXACT [] synonym: "xanthophyll formation" EXACT [] synonym: "xanthophyll synthesis" EXACT [] is_a: GO:0016117 ! carotenoid biosynthetic process is_a: GO:0016122 ! xanthophyll metabolic process intersection_of: GO:0009058 ! biosynthetic process intersection_of: RO:0004008 CHEBI:27325 ! has primary output relationship: RO:0004008 CHEBI:27325 ! has primary output property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0016124 name: xanthophyll catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of xanthophylls, oxygen-containing carotenoids." [GOC:go_curators] synonym: "xanthophyll breakdown" EXACT [] synonym: "xanthophyll catabolism" EXACT [] synonym: "xanthophyll degradation" EXACT [] is_a: GO:0016118 ! carotenoid catabolic process is_a: GO:0016122 ! xanthophyll metabolic process intersection_of: GO:0009056 ! catabolic process intersection_of: RO:0004009 CHEBI:27325 ! has primary input relationship: RO:0004009 CHEBI:27325 ! has primary input property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0016192 name: vesicle-mediated transport namespace: biological_process def: "A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000] subset: goslim_candida subset: goslim_chembl subset: goslim_drosophila subset: goslim_euk_cellular_processes_ribbon subset: goslim_generic subset: goslim_pir subset: goslim_pombe synonym: "nonselective vesicle transport" NARROW [] synonym: "protein sorting along secretory pathway" RELATED [] synonym: "vesicle trafficking" RELATED [] synonym: "vesicle transport" EXACT [] synonym: "vesicular transport" EXACT [GOC:mah] is_a: GO:0006810 ! transport is_a: GO:0009987 ! cellular process intersection_of: GO:0006810 ! transport intersection_of: RO:0002608 GO:0031982 ! process has causal agent vesicle relationship: RO:0002608 GO:0031982 ! process has causal agent vesicle property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/25421" xsd:anyURI [Term] id: GO:0016202 name: regulation of striated muscle tissue development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of striated muscle development." [GOC:go_curators] is_a: GO:0048634 ! regulation of muscle organ development is_a: GO:1901861 ! regulation of muscle tissue development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0014706 ! regulates striated muscle tissue development relationship: RO:0002211 GO:0014706 ! regulates striated muscle tissue development [Term] id: GO:0016301 name: kinase activity namespace: molecular_function def: "Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732] comment: Note that this term encompasses all activities that transfer a single phosphate group; although ATP is by far the most common phosphate donor, reactions using other phosphate donors are included in this term. subset: goslim_chembl subset: goslim_drosophila subset: goslim_metagenomics subset: goslim_plant subset: goslim_plant_ribbon subset: goslim_yeast synonym: "phosphokinase activity" EXACT [] xref: Reactome:R-HSA-6788855 "FN3KRP phosphorylates PsiAm, RibAm" xref: Reactome:R-HSA-6788867 "FN3K phosphorylates ketosamines" is_a: GO:0016772 ! transferase activity, transferring phosphorus-containing groups [Term] id: GO:0016310 name: phosphorylation namespace: biological_process def: "The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide." [ISBN:0198506732] subset: gocheck_obsoletion_candidate subset: goslim_chembl subset: goslim_metagenomics xref: Wikipedia:Phosphorylation is_a: GO:0006796 ! phosphate-containing compound metabolic process property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/26424" xsd:anyURI [Term] id: GO:0016319 name: mushroom body development namespace: biological_process def: "The process whose specific outcome is the progression of the mushroom body over time, from its formation to the mature structure. The mushroom body is composed of the prominent neuropil structures of the insect central brain, thought to be crucial for olfactory associated learning. These consist mainly of a bulbous calyx and tightly packaged arrays of thin parallel fibers of the Kenyon cells." [PMID:8790424] is_a: GO:0048856 ! anatomical structure development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0001058 ! results in development of mushroom body relationship: BFO:0000050 GO:0007420 ! part of brain development relationship: RO:0002296 UBERON:0001058 ! results in development of mushroom body [Term] id: GO:0016321 name: female meiosis chromosome segregation namespace: biological_process def: "The cell cycle process in which genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets during the meiotic cell cycle in a female." [GOC:ai] is_a: GO:0045132 ! meiotic chromosome segregation intersection_of: GO:0098813 ! nuclear chromosome segregation intersection_of: BFO:0000050 GO:0007143 ! part of female meiotic nuclear division relationship: BFO:0000050 GO:0007143 ! part of female meiotic nuclear division property_value: RO:0002161 NCBITaxon:4751 [Term] id: GO:0016325 name: oocyte microtubule cytoskeleton organization namespace: biological_process def: "Formation and maintenance of a polarized microtubule array originating from a microtubule-organizing center (MTOC) in the oocyte. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:11231123] synonym: "oocyte microtubule cytoskeleton organisation" EXACT [] is_a: GO:0030951 ! establishment or maintenance of microtubule cytoskeleton polarity intersection_of: GO:0016043 ! cellular component organization intersection_of: BFO:0000066 CL:0000023 ! occurs in oocyte intersection_of: RO:0002592 GO:0015630 ! results in organization of microtubule cytoskeleton relationship: BFO:0000050 GO:0007308 ! part of oocyte construction relationship: BFO:0000066 CL:0000023 ! occurs in oocyte [Term] id: GO:0016331 name: morphogenesis of embryonic epithelium namespace: biological_process def: "The process in which the anatomical structures of embryonic epithelia are generated and organized." [GOC:jl] is_a: GO:0002009 ! morphogenesis of an epithelium is_a: GO:0048598 ! embryonic morphogenesis [Term] id: GO:0016358 name: dendrite development namespace: biological_process def: "The process whose specific outcome is the progression of the dendrite over time, from its formation to the mature structure." [GOC:aruk, GOC:bc, GOC:jl, ISBN:0198506732, PMID:22683681] is_a: GO:0031175 ! neuron projection development is_a: GO:0048856 ! anatomical structure development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 GO:0030425 ! results in development of dendrite relationship: RO:0002296 GO:0030425 ! results in development of dendrite [Term] id: GO:0016444 name: somatic cell DNA recombination namespace: biological_process def: "Recombination occurring within or between DNA molecules in somatic cells." [GOC:ma] is_a: GO:0006310 ! DNA recombination property_value: RO:0002161 NCBITaxon:4751 [Term] id: GO:0016445 name: somatic diversification of immunoglobulins namespace: biological_process def: "The somatic process that results in the generation of sequence diversity of immunoglobulins." [GOC:add, GOC:ma, ISBN:0781735149] synonym: "somatic diversification of antibodies" EXACT [] is_a: GO:0002200 ! somatic diversification of immune receptors relationship: BFO:0000050 GO:0002377 ! part of immunoglobulin production property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4895 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0016446 name: somatic hypermutation of immunoglobulin genes namespace: biological_process def: "Mutations occurring somatically that result in amino acid changes in the rearranged V regions of immunoglobulins." [GOC:add, ISBN:0781735149, PMID:11205330, PMID:11205333, PMID:14975236, PMID:7813007] synonym: "somatic hypermutation of antibody genes" EXACT [] is_a: GO:0002566 ! somatic diversification of immune receptors via somatic mutation is_a: GO:0016445 ! somatic diversification of immunoglobulins property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4895 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0016447 name: somatic recombination of immunoglobulin gene segments namespace: biological_process def: "The process in which immunoglobulin genes are formed through recombination of the germline genetic elements, as known as immunoglobulin gene segments, within a single locus." [GOC:add, ISBN:0781735149] synonym: "somatic recombination of antibody gene segments" EXACT [] is_a: GO:0002562 ! somatic diversification of immune receptors via germline recombination within a single locus is_a: GO:0016445 ! somatic diversification of immunoglobulins property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4751 [Term] id: GO:0016462 name: pyrophosphatase activity namespace: molecular_function def: "Catalysis of the hydrolysis of a pyrophosphate bond (diphosphate bond) between two phosphate groups." [GOC:curators, https://en.wikipedia.org/wiki/Pyrophosphatase] xref: Reactome:R-HSA-6810472 "NUDT13 hydrolyses AP6A to AP4 and ADP" is_a: GO:0016818 ! hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides [Term] id: GO:0016477 name: cell migration namespace: biological_process def: "The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues." [GOC:cjm, GOC:dph, GOC:ems, GOC:pf, Wikipedia:Cell_migration] xref: Wikipedia:Cell_migration is_a: GO:0048870 ! cell motility property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/24787" xsd:anyURI property_value: RO:0002161 NCBITaxon:4890 [Term] id: GO:0016482 name: cytosolic transport namespace: biological_process def: "The directed movement of substances or organelles within the cytosol." [GOC:ai] is_a: GO:0046907 ! intracellular transport intersection_of: GO:0006810 ! transport intersection_of: BFO:0000066 GO:0005829 ! occurs in cytosol relationship: BFO:0000066 GO:0005829 ! occurs in cytosol property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/26386" xsd:anyURI [Term] id: GO:0016485 name: protein processing namespace: biological_process def: "Any protein maturation process achieved by the cleavage of a peptide bond or bonds within a protein. Protein maturation is the process leading to the attainment of the full functional capacity of a protein." [GOC:curators, GOC:jl, GOC:jsg] subset: goslim_chembl synonym: "peptidolysis during protein maturation" RELATED [GOC:mah] synonym: "protein maturation by peptide bond cleavage" EXACT [GOC:bf] synonym: "protein maturation by peptide bond hydrolysis" EXACT [GOC:mah] synonym: "protein maturation by proteolysis" RELATED [GOC:mah] xref: Reactome:R-HSA-9033500 "TYSND1 cleaves peroxisomal proteins" is_a: GO:0006508 ! proteolysis is_a: GO:0051604 ! protein maturation [Term] id: GO:0016486 name: peptide hormone processing namespace: biological_process def: "The generation of a mature peptide hormone by posttranslational processing of a prohormone." [GOC:mah] xref: Reactome:R-HSA-209952 "Peptide hormone biosynthesis" xref: Reactome:R-HSA-400508 "Incretin synthesis, secretion, and inactivation" xref: Reactome:R-HSA-422085 "Synthesis, secretion, and deacylation of Ghrelin" is_a: GO:0042445 ! hormone metabolic process is_a: GO:0043603 ! amide metabolic process is_a: GO:0140448 ! signaling receptor ligand precursor processing intersection_of: GO:0016485 ! protein processing intersection_of: RO:0004007 CHEBI:25905 ! has primary input or output relationship: RO:0004007 CHEBI:25905 ! has primary input or output property_value: RO:0002161 NCBITaxon:4895 [Term] id: GO:0016500 name: protein-hormone receptor activity namespace: molecular_function def: "Combining with a protein hormone to initiate a change in cell activity." [GOC:mah] is_a: GO:0038023 ! signaling receptor activity [Term] id: GO:0016502 name: nucleotide receptor activity namespace: molecular_function def: "Combining with a nucleotide and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. A nucleotide is a compound that consists of a nucleoside esterified with a phosphate molecule." [GOC:signaling, ISBN:0198506732] is_a: BFO:0000003 is_a: GO:0004888 ! transmembrane signaling receptor activity intersection_of: GO:0038023 ! signaling receptor activity intersection_of: RO:0004009 CHEBI:36976 ! has primary input relationship: BFO:0000051 GO:0000166 ! has part nucleotide binding relationship: RO:0004009 CHEBI:36976 ! has primary input [Term] id: GO:0016525 name: negative regulation of angiogenesis namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of angiogenesis." [GOC:go_curators] synonym: "down regulation of angiogenesis" EXACT [] synonym: "down-regulation of angiogenesis" EXACT [] synonym: "downregulation of angiogenesis" EXACT [] synonym: "inhibition of angiogenesis" NARROW [] is_a: GO:0045765 ! regulation of angiogenesis is_a: GO:2000181 ! negative regulation of blood vessel morphogenesis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0001525 ! negatively regulates angiogenesis relationship: RO:0002212 GO:0001525 ! negatively regulates angiogenesis [Term] id: GO:0016528 name: sarcoplasm namespace: cellular_component def: "The cytoplasm of a muscle cell; includes the sarcoplasmic reticulum." [ISBN:0198547684] xref: Wikipedia:Sarcoplasm is_a: GO:0005737 ! cytoplasm intersection_of: GO:0005737 ! cytoplasm intersection_of: BFO:0000050 CL:0000187 ! part of muscle cell relationship: BFO:0000050 CL:0000187 ! part of muscle cell [Term] id: GO:0016594 name: glycine binding namespace: molecular_function def: "Binding to glycine, aminoethanoic acid." [GOC:ai] synonym: "aminoacetic acid binding" EXACT [] synonym: "aminoethanoic acid binding" EXACT [] synonym: "Gly binding" EXACT [] is_a: GO:0016597 ! amino acid binding is_a: GO:0031406 ! carboxylic acid binding is_a: GO:0043169 ! cation binding intersection_of: GO:0005488 ! binding intersection_of: RO:0004009 CHEBI:57305 ! has primary input relationship: RO:0004009 CHEBI:57305 ! has primary input [Term] id: GO:0016595 name: glutamate binding namespace: molecular_function def: "Binding to glutamate, the anion of 2-aminopentanedioic acid." [GOC:ai] synonym: "glutamic acid binding" EXACT [] is_a: GO:0016597 ! amino acid binding is_a: GO:0031406 ! carboxylic acid binding intersection_of: GO:0005488 ! binding intersection_of: RO:0004009 CHEBI:14321 ! has primary input relationship: RO:0004009 CHEBI:14321 ! has primary input [Term] id: GO:0016597 name: amino acid binding namespace: molecular_function def: "Binding to an amino acid, organic acids containing one or more amino substituents." [GOC:ai] subset: goslim_metagenomics subset: goslim_pir is_a: BFO:0000003 is_a: GO:0005488 ! binding intersection_of: GO:0005488 ! binding intersection_of: RO:0004009 CHEBI:35238 ! has primary input relationship: RO:0004009 CHEBI:35238 ! has primary input [Term] id: GO:0016740 name: transferase activity namespace: molecular_function def: "Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [EC:2.-.-.-] subset: goslim_candida subset: goslim_chembl subset: goslim_drosophila subset: goslim_generic subset: goslim_metagenomics subset: goslim_mouse subset: goslim_pir subset: goslim_plant subset: goslim_prokaryote subset: goslim_yeast xref: EC:2.-.-.- xref: Reactome:R-HSA-1483089 "PE is converted to PS by PTDSS2" xref: Reactome:R-HSA-1483186 "PC is converted to PS by PTDSS1" xref: Reactome:R-HSA-5333607 "GSSeH combines with bGalNAc derivative to form GSSebGalNac" xref: Reactome:R-HSA-5668414 "TRAF2 ubiquitinates cIAP1,2 in cIAP1,2:TRAF1:TRAF2:TRAF3:NIK" xref: Reactome:R-HSA-8868783 "TSR3 transfers aminocarboxypropyl group from S-adenosylmethionine to N(1)-methylpseudouridine-1248 of 18SE rRNA yielding N(1)-methyl-N(3)-aminocarboxypropylpseudouridine-1248" is_a: GO:0003824 ! catalytic activity [Term] id: GO:0016746 name: acyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor)." [EC:2.3.-.-] subset: goslim_chembl subset: goslim_drosophila synonym: "transferase activity, transferring acyl groups" EXACT [] xref: EC:2.3.-.- xref: Reactome:R-HSA-159431 "Cytosolic chenodeoxycholoyl-CoA or choloyl-CoA are conjugated with glycine or taurine" xref: Reactome:R-HSA-192312 "Choloyl CoA reacts with glycine or taurine to form glycocholate or taurocholate" xref: Reactome:R-HSA-193491 "Chenodeoxycholoyl CoA reacts with glycine or taurine to form glycochenodeoxycholate or taurochenodeoxycholate" xref: Reactome:R-HSA-8858298 "HRASLS transfer acyl group from PC to PE to form NAPE" is_a: GO:0016740 ! transferase activity property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/20486" xsd:anyURI [Term] id: GO:0016755 name: aminoacyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of an amino-acyl group from one compound (donor) to another (acceptor)." [GOC:jl] synonym: "transferase activity, transferring amino-acyl groups" EXACT [] xref: EC:2.3.2.- is_a: GO:0016746 ! acyltransferase activity [Term] id: GO:0016772 name: transferase activity, transferring phosphorus-containing groups namespace: molecular_function def: "Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [EC:2.7.-.-] comment: Note that this term encompasses all kinase activities, as well as activities that transfer other phosphorus-containing groups such as diphosphate or nucleotides. subset: goslim_chembl xref: EC:2.7.-.- xref: Reactome:R-HSA-9932322 "BcsG transfers pEtN from PE onto cellulose" is_a: GO:0016740 ! transferase activity [Term] id: GO:0016773 name: phosphotransferase activity, alcohol group as acceptor namespace: molecular_function def: "Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor)." [EC:2.7.1.-] subset: goslim_drosophila xref: EC:2.7.1.- xref: Reactome:R-HSA-2161193 "abacavir + AMP => abacavir monophosphate + adenosine" xref: Reactome:R-HSA-9941039 "FAM20B phosphorylates Xyl moiety" is_a: GO:0016772 ! transferase activity, transferring phosphorus-containing groups [Term] id: GO:0016787 name: hydrolase activity namespace: molecular_function def: "Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc." [ISBN:0198506732] subset: goslim_candida subset: goslim_chembl subset: goslim_drosophila subset: goslim_generic subset: goslim_metagenomics subset: goslim_mouse subset: goslim_pir subset: goslim_plant subset: goslim_prokaryote subset: goslim_yeast xref: EC:3.-.-.- xref: Reactome:R-HSA-1236938 "Partial proteolysis of antigen in phagolysosomes" xref: Reactome:R-HSA-2029475 "Production of AA by iPLA2 upon FCGR activation" xref: Reactome:R-HSA-5694583 "ABHD4 hydrolyses NAPE" xref: Reactome:R-HSA-5695964 "ABHD14B hydrolyses PNPB" xref: Reactome:R-HSA-6786190 "CMBL hydrolyses OM to OLMS" xref: Reactome:R-HSA-6788295 "HDHD1:Mg2+ dephosphorylates PURIDP" xref: Reactome:R-HSA-8938314 "ENPPs hydrolyse CoA-SH to PPANT, PAP" xref: Reactome:R-HSA-8952137 "Phospholipid phosphatase 6 hydrolyses Presqualene diphosphate to presqualene monophosphate" xref: Reactome:R-HSA-9942295 "QNG1 hydrolyzes queuosine 5'-monophosphate yielding queuine and ribose 5'-monophosphate" is_a: GO:0003824 ! catalytic activity [Term] id: GO:0016817 name: hydrolase activity, acting on acid anhydrides namespace: molecular_function def: "Catalysis of the hydrolysis of any acid anhydride." [GOC:jl] synonym: "hydrolase activity, acting on acid anhydrides, involved in cellular and subcellular movement" NARROW [] xref: EC:3.6.-.- is_a: GO:0016787 ! hydrolase activity [Term] id: GO:0016818 name: hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides namespace: molecular_function def: "Catalysis of the hydrolysis of any acid anhydride which contains phosphorus." [GOC:jl] xref: EC:3.6.1.- xref: Reactome:R-HSA-9731590 "NUDT1 hydrolyzes O6-methyl-dGTP to O6-methyl-dGMP" xref: Reactome:R-HSA-9731613 "NUDT1 hydrolyzes N6-methyl-dATP to N6-methyl-dAMP" xref: Reactome:R-HSA-9731632 "NUDT1 hydrolyzes N6-methyl-ATP to N6-methyl-AMP" is_a: GO:0016817 ! hydrolase activity, acting on acid anhydrides [Term] id: GO:0016853 name: isomerase activity namespace: molecular_function def: "Catalysis of the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5." [ISBN:0198506732] subset: goslim_candida subset: goslim_chembl subset: goslim_drosophila subset: goslim_generic subset: goslim_metagenomics subset: goslim_pir subset: goslim_prokaryote subset: goslim_yeast synonym: "other isomerase activity" NARROW [] xref: EC:5.-.-.- xref: Reactome:R-HSA-2161666 "PGA2 is isomerised to PGC2" xref: Reactome:R-HSA-2161735 "PGC2 is isomerised to PGB2" xref: Reactome:R-HSA-6787623 "TSTA3 dimer epimerises GDP-DHDMan to GDP-KDGal" is_a: GO:0003824 ! catalytic activity [Term] id: GO:0016887 name: ATP hydrolysis activity namespace: molecular_function def: "Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065] comment: Note that this term is meant to specifically represent the ATPase activity of proteins using ATP as a source of energy to drive a reaction. If possible, gene products should also be annotated to a child of 'ATP-dependent activity ; GO:0140657', to capture their overall function. synonym: "adenosine 5'-triphosphatase activity" EXACT [] synonym: "adenosine triphosphatase activity" EXACT [] synonym: "adenosinetriphosphatase activity" EXACT [] synonym: "ATP hydrolase activity" EXACT [] synonym: "ATP monophosphatase activity" RELATED [] synonym: "ATP phosphohydrolase activity" EXACT [] xref: Reactome:R-HSA-159101 "NXF1:NXT1 (TAP:p15) binds capped mRNA:CBC:EJC:TREX (minus DDX39B)" xref: Reactome:R-HSA-3371422 "ATP hydrolysis by HSP70" xref: Reactome:R-HSA-416985 "Trafficking of GluR2-containing AMPA receptors to synapse" xref: Reactome:R-HSA-5618093 "ATP hydrolysis by HSP90" xref: Reactome:R-HSA-5654989 "SPRTN:VCP-mediated release of POLH from monoUb:K164-PCNA" xref: Reactome:R-HSA-5694425 "NSF ATPase activity dissociates cis-SNARE" xref: Reactome:R-HSA-6809015 "NSF ATPase activity dissociates cis-SNARE at cis-Golgi" xref: Reactome:R-HSA-6811422 "NSF ATPase activity dissociates cis-SNARE at the ER" xref: Reactome:R-HSA-6814670 "ATP hydrolysis by RHOBTB3 promotes PLIN3 dissociation" xref: Reactome:R-HSA-6814678 "ATP hydrolysis by NSF disassembles the cis-SNARE at the TGN" xref: Reactome:R-HSA-6814683 "NSF-dependent ATP hydrolysis disassembles the cis-SNARE at the TGN" xref: Reactome:R-HSA-8847638 "ATP hydrolysis by NSF disassembles the cis-SNARE at the Golgi membrane" xref: Reactome:R-HSA-8868658 "HSPA8-mediated ATP hydrolysis promotes vesicle uncoating" xref: Reactome:R-HSA-8939203 "HSP90-dependent ATP hydrolysis promotes release of ESR:ESTG from chaperone complex" xref: Reactome:R-HSA-9038161 "Progesterone stimulation promotes PGR:P4 binding to ESR1:ESTG" xref: Reactome:R-HSA-917693 "ESCRT Disassembly" xref: Reactome:R-HSA-9609860 "Tail-anchored protein:SGTA:BAG6:GET4:UBL4A:ASNA1:ATP dissociates and ASNA1 hydrolyzes ATP yielding Tail-anchored protein:ASNA1:ADP" xref: Reactome:R-HSA-9668415 "VPS4 mediates disassembly of ESCRTIII subunits to promote sealing of holes in the nuclear envelope" xref: Reactome:R-HSA-9706399 "RHOBTB3 hydrolyzes ATP" xref: Reactome:R-HSA-9749350 "ATP-dependent release of CDT1 from the OCCM complex" xref: Reactome:R-HSA-9948300 "RQT complex:K63polyUb-80S ribosome dissociates yielding K63polyUb-40S subunit and 60S subunit:peptidyl-tRNA with nascent peptide" xref: Reactome:R-HSA-9949632 "VCP hexamer extracts K48 polyubiquitinated alanine-tailed nascent peptide from VCP hexamer:UFD1:NPLOC4:LTN1:NEMF:TCF25:60S ribosome subunit:K48polyUb-nascent peptide" xref: Reactome:R-HSA-9955731 "ABCE1:PELO:80S Ribosome:non-stop mRNA:peptidyl-tRNA with elongating peptide dissociates yielding ABCE1:40S ribosomal subunit, PELO, and 60S ribosomal subunit:peptidyl-tRNA with nascent peptide" xref: RHEA:13065 is_a: GO:0017111 ! ribonucleoside triphosphate phosphatase activity relationship: BFO:0000050 GO:0140657 ! part of ATP-dependent activity relationship: has_participant CHEBI:30616 relationship: has_participant CHEBI:456216 property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/19078" xsd:anyURI property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/20498" xsd:anyURI property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/21612" xsd:anyURI property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/22371" xsd:anyURI [Term] id: GO:0016907 name: G protein-coupled acetylcholine receptor activity namespace: molecular_function def: "Combining with acetylcholine and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, GOC:fj, GOC:mah] synonym: "acetylcholine receptor activity, G-protein coupled" EXACT [GOC:bf] synonym: "G protein coupled acetylcholine receptor activity" EXACT [] synonym: "G-protein coupled acetylcholine receptor activity" EXACT [] synonym: "metabotropic acetylcholine receptor activity" EXACT [] synonym: "muscarinic acetylcholine receptor activity" EXACT [] xref: Reactome:R-HSA-400012 "Acetylcholine binds Muscarinic Acetylcholine Receptor M3" is_a: GO:0008227 ! G protein-coupled amine receptor activity is_a: GO:0015464 ! acetylcholine receptor activity is_a: GO:0099528 ! G protein-coupled neurotransmitter receptor activity intersection_of: GO:0004930 ! G protein-coupled receptor activity intersection_of: RO:0004009 CHEBI:15355 ! has primary input relationship: BFO:0000050 GO:0007213 ! part of G protein-coupled acetylcholine receptor signaling pathway [Term] id: GO:0016917 name: GABA receptor activity namespace: molecular_function def: "Combining with gamma-aminobutyric acid (GABA), and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. (GABA, 4-aminobutyrate) is an amino acid which acts as a neurotransmitter in some organisms." [GOC:jl, GOC:signaling, PMID:10637650] comment: See also the molecular function term 'neurotransmitter receptor activity ; GO:0030594'. synonym: "4-aminobutanoate receptor activity" EXACT [] synonym: "4-aminobutyrate receptor activity" EXACT [] synonym: "GABA binding" EXACT [] synonym: "gamma-aminobutyrate binding" EXACT [] synonym: "gamma-aminobutyric acid binding" EXACT [] synonym: "gamma-aminobutyric acid receptor activity" EXACT [] is_a: BFO:0000003 is_a: GO:0004888 ! transmembrane signaling receptor activity intersection_of: GO:0038023 ! signaling receptor activity intersection_of: RO:0004009 CHEBI:59888 ! has primary input relationship: RO:0004009 CHEBI:59888 ! has primary input [Term] id: GO:0016922 name: nuclear receptor binding namespace: molecular_function def: "Binding to a nuclear receptor protein. Nuclear receptor proteins are DNA-binding transcription factors which are regulated by binding to a ligand." [PMID:7776974] synonym: "ligand-dependent nuclear receptor binding" EXACT [] synonym: "ligand-dependent nuclear receptor interactor activity" RELATED [] synonym: "nuclear hormone receptor binding" EXACT [] synonym: "steroid hormone receptor binding" BROAD [] is_a: GO:0061629 ! RNA polymerase II-specific DNA-binding transcription factor binding property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4751 [Term] id: GO:0017046 name: peptide hormone binding namespace: molecular_function def: "Binding to a peptide with hormonal activity in animals." [GOC:jl, ISBN:0198506732] synonym: "polypeptide hormone binding" EXACT [] is_a: GO:0033218 ! amide binding is_a: GO:0042562 ! hormone binding intersection_of: GO:0005488 ! binding intersection_of: RO:0004009 CHEBI:25905 ! has primary input relationship: RO:0004009 CHEBI:25905 ! has primary input [Term] id: GO:0017076 name: purine nucleotide binding namespace: molecular_function def: "Binding to a purine nucleotide, a compound consisting of a purine nucleoside esterified with (ortho)phosphate." [GOC:ai] is_a: GO:0000166 ! nucleotide binding intersection_of: GO:0005488 ! binding intersection_of: RO:0004009 CHEBI:26395 ! has primary input relationship: RO:0004009 CHEBI:26395 ! has primary input [Term] id: GO:0017111 name: ribonucleoside triphosphate phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: a ribonucleoside triphosphate + H2O = a ribonucleoside diphosphate + H+ + phosphate." [RHEA:23680] subset: goslim_chembl subset: goslim_metagenomics synonym: "apyrase activity" BROAD [] synonym: "NTPase activity" EXACT [] synonym: "nucleoside 5-triphosphatase activity" BROAD [EC:3.6.1.15] synonym: "nucleoside triphosphatase activity" BROAD [] synonym: "nucleoside triphosphate hydrolase activity" BROAD [] synonym: "nucleoside triphosphate phosphatase activity" BROAD [] synonym: "nucleoside triphosphate phosphohydrolase activity" RELATED [] synonym: "nucleoside-5-triphosphate phosphohydrolase activity" RELATED [] synonym: "nucleoside-triphosphatase activity" BROAD [] xref: EC:3.6.1.15 xref: MetaCyc:NUCLEOSIDE-TRIPHOSPHATASE-RXN xref: Reactome:R-HSA-8850846 "NTPDase1 hydrolyzes nucleoside triphosphates" xref: Reactome:R-HSA-8851089 "NTPDase2 hydrolyzes nucleoside triphosphates" xref: Reactome:R-HSA-8851110 "NTPDase3 hydrolyzes nucleoside triphosphates" xref: Reactome:R-HSA-8851234 "NTPDase4 hydrolyzes nucleoside triphosphates" xref: Reactome:R-HSA-8851494 "NTPDase7 hydrolyzes nucleoside triphosphates" xref: Reactome:R-HSA-8851538 "NTPDase8 hydrolyzes nucleoside triphosphates" xref: RHEA:23680 is_a: BFO:0000003 is_a: GO:0016462 ! pyrophosphatase activity relationship: has_participant CHEBI:15377 relationship: has_participant CHEBI:15378 relationship: has_participant CHEBI:43474 relationship: has_participant CHEBI:57930 relationship: has_participant CHEBI:61557 property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/21232" xsd:anyURI property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/23401" xsd:anyURI [Term] id: GO:0017126 name: nucleologenesis namespace: biological_process def: "A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a nucleolus, a small, dense body one or more of which are present in the nucleus of eukaryotic cells." [GOC:jl, ISBN:0198506732] synonym: "nucleolus assembly" NARROW [GOC:mah] synonym: "nucleolus biogenesis" EXACT [] is_a: GO:0007000 ! nucleolus organization is_a: GO:0044085 ! cellular component biogenesis intersection_of: GO:0044085 ! cellular component biogenesis intersection_of: RO:0004008 GO:0005730 ! has primary output nucleolus relationship: RO:0004008 GO:0005730 ! has primary output nucleolus [Term] id: GO:0017145 name: stem cell division namespace: biological_process def: "The self-renewing division of a stem cell. A stem cell is an undifferentiated cell, in the embryo or adult, that can undergo unlimited division and give rise to one or several different cell types." [GOC:jid, ISBN:0582227089] synonym: "stem cell renewal" EXACT [] is_a: BFO:0000003 is_a: GO:0051301 ! cell division intersection_of: GO:0051301 ! cell division intersection_of: RO:0004009 CL:0000034 ! has primary input stem cell relationship: RO:0004009 CL:0000034 ! has primary input stem cell property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4751 [Term] id: GO:0017148 name: negative regulation of translation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA." [GOC:isa_complete] synonym: "down regulation of protein biosynthetic process" EXACT [] synonym: "down-regulation of protein biosynthetic process" EXACT [] synonym: "downregulation of protein biosynthetic process" EXACT [] synonym: "inhibition of protein biosynthetic process" NARROW [] synonym: "negative regulation of protein anabolism" EXACT [] synonym: "negative regulation of protein biosynthesis" EXACT [] synonym: "negative regulation of protein biosynthetic process" EXACT [] synonym: "negative regulation of protein formation" EXACT [] synonym: "negative regulation of protein synthesis" EXACT [] synonym: "protein biosynthesis inhibitor activity" RELATED [] synonym: "protein biosynthetic process inhibitor activity" RELATED [] is_a: GO:0006417 ! regulation of translation is_a: GO:0010629 ! negative regulation of gene expression is_a: GO:0051248 ! negative regulation of protein metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0006412 ! negatively regulates translation relationship: RO:0002212 GO:0006412 ! negatively regulates translation [Term] id: GO:0017156 name: calcium-ion regulated exocytosis namespace: biological_process def: "The release of intracellular molecules (e.g. hormones, matrix proteins) contained within a membrane-bounded vesicle by fusion of the vesicle with the plasma membrane of a cell, induced by a rise in cytosolic calcium-ion levels." [GOC:go_curators] comment: Note that the calcium regulated exocytosis pathway can be leaky: some level of exocytosis via this pathway occurs spontaneously. This phenomenon underlies spontaneous neurotransmitter release from presynapses. This phenomenon is distinct from the unregulated, calcium independent exocytosis pathway. synonym: "calcium ion-dependent exocytosis" EXACT [] is_a: GO:0045055 ! regulated exocytosis intersection_of: GO:0045055 ! regulated exocytosis intersection_of: RO:0002334 GO:0007204 ! regulated by positive regulation of cytosolic calcium ion concentration relationship: RO:0002334 GO:0007204 ! regulated by positive regulation of cytosolic calcium ion concentration [Term] id: GO:0017157 name: regulation of exocytosis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of exocytosis." [GOC:go_curators] is_a: GO:0060627 ! regulation of vesicle-mediated transport is_a: GO:1903530 ! regulation of secretion by cell intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0006887 ! regulates exocytosis relationship: RO:0002211 GO:0006887 ! regulates exocytosis [Term] id: GO:0017158 name: regulation of calcium ion-dependent exocytosis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of calcium ion-dependent exocytosis." [GOC:go_curators] is_a: GO:1903305 ! regulation of regulated secretory pathway intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0017156 ! regulates calcium-ion regulated exocytosis relationship: RO:0002211 GO:0017156 ! regulates calcium-ion regulated exocytosis [Term] id: GO:0018108 name: peptidyl-tyrosine phosphorylation namespace: biological_process def: "The phosphorylation of peptidyl-tyrosine to form peptidyl-O4'-phospho-L-tyrosine." [RESID:AA0039] subset: gocheck_obsoletion_candidate xref: RESID:AA0039 is_a: GO:0006468 ! protein phosphorylation is_a: GO:0018212 ! peptidyl-tyrosine modification [Term] id: GO:0018193 name: peptidyl-amino acid modification namespace: biological_process def: "The alteration of an amino acid residue in a peptide." [GOC:mah] subset: gocheck_do_not_annotate subset: goslim_yeast is_a: GO:0036211 ! protein modification process relationship: RO:0004009 CHEBI:33708 ! has primary input [Term] id: GO:0018212 name: peptidyl-tyrosine modification namespace: biological_process def: "The modification of peptidyl-tyrosine." [GOC:go_curators] subset: gocheck_obsoletion_candidate is_a: GO:0018193 ! peptidyl-amino acid modification [Term] id: GO:0018958 name: phenol-containing compound metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a phenol, any compound containing one or more hydroxyl groups directly attached to an aromatic carbon ring." [ISBN:0198506732] comment: Note that phenol metabolism is not included as a child of 'xenobiotic metabolism' because although it is synthesized industrially, phenol is also found naturally in animal wastes and other organic materials. It is often formed by the activity of microorganisms, which can chemically modify a variety of xenobiotic and naturally occurring phenolic compounds. synonym: "carbolic acid metabolic process" EXACT [] synonym: "carbolic acid metabolism" EXACT [] synonym: "hydroxybenzene metabolic process" EXACT [] synonym: "hydroxybenzene metabolism" EXACT [] synonym: "phenol-containing compound metabolism" EXACT [] xref: UM-BBD_pathwayID:phe is_a: BFO:0000003 is_a: GO:0008152 ! metabolic process intersection_of: GO:0008152 ! metabolic process intersection_of: RO:0004007 CHEBI:33853 ! has primary input or output relationship: RO:0004007 CHEBI:33853 ! has primary input or output [Term] id: GO:0019093 name: mitochondrial RNA localization namespace: biological_process def: "Any process in which mitochondrial RNA is transported to, or maintained in, a specific location." [GOC:ai] synonym: "establishment and maintenance of mitochondrial RNA localization" EXACT [] synonym: "mitochondrial RNA localisation" EXACT [GOC:mah] synonym: "mtRNA localization" EXACT [] is_a: BFO:0000003 is_a: GO:0006403 ! RNA localization intersection_of: GO:0006403 ! RNA localization intersection_of: BFO:0000066 GO:0005739 ! occurs in mitochondrion relationship: BFO:0000066 GO:0005739 ! occurs in mitochondrion relationship: RO:0002162 NCBITaxon:2759 ! in taxon Eukaryota [Term] id: GO:0019098 name: reproductive behavior namespace: biological_process def: "The specific behavior of an organism that is associated with reproduction." [GOC:jl, GOC:pr] synonym: "multi-organism reproductive behavior" NARROW [] synonym: "multicellular organism reproductive behavior" NARROW [] synonym: "reproductive behavior in a multicellular organism" EXACT [] synonym: "reproductive behaviour" EXACT [] synonym: "single-organism reproductive behavior" RELATED [] is_a: GO:0007610 ! behavior is_a: GO:0048609 ! multicellular organismal reproductive process intersection_of: GO:0007610 ! behavior intersection_of: GO:0048609 ! multicellular organismal reproductive process property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/23491" xsd:anyURI creation_date: 2012-09-19T16:01:37Z [Term] id: GO:0019199 name: transmembrane receptor protein kinase activity namespace: molecular_function def: "Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: a protein + ATP = a phosphoprotein + ADP." [GOC:mah] xref: Reactome:R-HSA-8983059 "STAT3 is phosphorylated by TSLP:IL7R:CRLF2:STAT3 complex" xref: Reactome:R-HSA-8983063 "JAK3 in IL7:p-Y449-IL7R:JAK1:IL2RG:JAK3 is phosphorylated" is_a: GO:0004672 ! protein kinase activity is_a: GO:0004888 ! transmembrane signaling receptor activity [Term] id: GO:0019215 name: intermediate filament binding namespace: molecular_function def: "Binding to an intermediate filament, a distinct elongated structure, characteristically 10 nm in diameter, that occurs in the cytoplasm of higher eukaryotic cells. Intermediate filaments form a fibrous system, composed of chemically heterogeneous subunits and involved in mechanically integrating the various components of the cytoplasmic space." [ISBN:0198506732] is_a: BFO:0000003 is_a: GO:0005488 ! binding intersection_of: GO:0005488 ! binding intersection_of: RO:0004009 GO:0005882 ! has primary input intermediate filament relationship: RO:0004009 GO:0005882 ! has primary input intermediate filament [Term] id: GO:0019216 name: regulation of lipid metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving lipids." [GOC:go_curators] synonym: "regulation of lipid metabolism" EXACT [] xref: Reactome:R-HSA-2426168 "Activation of gene expression by SREBF (SREBP)" xref: Reactome:R-HSA-400206 "Regulation of lipid metabolism by PPARalpha" is_a: GO:0080090 ! regulation of primary metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0006629 ! regulates lipid metabolic process relationship: RO:0002211 GO:0006629 ! regulates lipid metabolic process [Term] id: GO:0019217 name: regulation of fatty acid metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving fatty acids." [GOC:go_curators] synonym: "regulation of fatty acid metabolism" EXACT [] is_a: GO:0010565 ! regulation of ketone metabolic process is_a: GO:0019216 ! regulation of lipid metabolic process is_a: GO:0062012 ! regulation of small molecule metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0006631 ! regulates fatty acid metabolic process relationship: RO:0002211 GO:0006631 ! regulates fatty acid metabolic process [Term] id: GO:0019218 name: regulation of steroid metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving steroids." [GOC:go_curators] synonym: "regulation of steroid metabolism" EXACT [] is_a: GO:0019216 ! regulation of lipid metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0008202 ! regulates steroid metabolic process relationship: RO:0002211 GO:0008202 ! regulates steroid metabolic process [Term] id: GO:0019219 name: regulation of nucleobase-containing compound metabolic process namespace: biological_process def: "Any cellular process that modulates the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:go_curators] synonym: "regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process" RELATED [GOC:dph, GOC:tb] synonym: "regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism" EXACT [] is_a: GO:0080090 ! regulation of primary metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0006139 ! regulates nucleobase-containing compound metabolic process relationship: RO:0002211 GO:0006139 ! regulates nucleobase-containing compound metabolic process [Term] id: GO:0019221 name: cytokine-mediated signaling pathway namespace: biological_process def: "The series of molecular signals initiated by the binding of a cytokine to a receptor on the surface of a cell, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:mah, GOC:signaling, PMID:19295629] synonym: "cytokine and chemokine mediated signaling pathway" EXACT [] synonym: "cytokine mediated signalling pathway" EXACT [] xref: Reactome:R-HSA-449147 "Signaling by Interleukins" xref: Reactome:R-HSA-913531 "Interferon Signaling" xref: Reactome:R-HSA-9607240 "FLT3 Signaling" xref: Reactome:R-HSA-9674555 "Signaling by CSF3 (G-CSF)" xref: Reactome:R-HSA-9680350 "Signaling by CSF1 (M-CSF) in myeloid cells" is_a: GO:0007166 ! cell surface receptor signaling pathway relationship: BFO:0000050 GO:0071345 ! part of cellular response to cytokine stimulus [Term] id: GO:0019222 name: regulation of metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism." [GOC:go_curators] subset: gocheck_do_not_annotate subset: goslim_metagenomics synonym: "regulation of metabolism" EXACT [] synonym: "regulation of multicellular organismal metabolic process" NARROW [] synonym: "regulation of organismal metabolic process" NARROW [GOC:tb] xref: Reactome:R-HSA-1989781 "PPARA activates gene expression" is_a: GO:0050794 ! regulation of cellular process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0008152 ! regulates metabolic process relationship: RO:0002211 GO:0008152 ! regulates metabolic process [Term] id: GO:0019226 name: transmission of nerve impulse namespace: biological_process def: "The neurological system process in which a signal is transmitted through the nervous system by a combination of action potential propagation and synaptic transmission." [GOC:curators, ISBN:0815316194] synonym: "conduction of nerve impulse" EXACT [GOC:dph] synonym: "signal transmission along a neuron" EXACT [] is_a: GO:0050877 ! nervous system process relationship: BFO:0000050 GO:0007154 ! part of cell communication relationship: BFO:0000051 GO:0001508 ! has part action potential relationship: BFO:0000051 GO:0007268 ! has part chemical synaptic transmission [Term] id: GO:0019228 name: neuronal action potential namespace: biological_process def: "An action potential that occurs in a neuron." [GOC:dph, GOC:isa_complete, GOC:tb] synonym: "generation of action potential" RELATED [GOC:dph, GOC:tb] is_a: GO:0001508 ! action potential intersection_of: GO:0001508 ! action potential intersection_of: BFO:0000066 CL:0000540 ! occurs in neuron relationship: BFO:0000050 GO:0019226 ! part of transmission of nerve impulse relationship: BFO:0000066 CL:0000540 ! occurs in neuron [Term] id: GO:0019230 name: proprioception namespace: biological_process def: "The series of events by which an organism senses the position, location, orientation, and movement of the body and its parts. Proprioception is mediated by proprioceptors, sensory nerve terminals found in muscles, tendons, and joint capsules, which give information concerning movements and position of the body. The receptors in the labyrinth are sometimes also considered proprioceptors." [ISBN:072168677X] xref: Wikipedia:Proprioception is_a: GO:0007600 ! sensory perception relationship: BFO:0000050 GO:0050884 ! part of neuromuscular process controlling posture [Term] id: GO:0019233 name: sensory perception of pain namespace: biological_process def: "The series of events required for an organism to receive a painful stimulus, convert it to a molecular signal, and recognize and characterize the signal. A painful stimulus is any physical or chemical event that has the potential to cause tissue damage (actual or perceived) and activates the nociceptive system." [GOC:curators] synonym: "nociception" RELATED [] synonym: "perception of physiological pain" NARROW [] xref: Wikipedia:Nociception is_a: GO:0007600 ! sensory perception property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/29807" xsd:anyURI [Term] id: GO:0019236 name: response to pheromone namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pheromone stimulus." [GOC:jl] synonym: "pheromone response" EXACT [] is_a: GO:0042221 ! response to chemical [Term] id: GO:0019252 name: starch biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of starch, the most important reserve polysaccharide in plants." [GOC:ai] synonym: "starch anabolism" EXACT [] synonym: "starch biosynthesis" EXACT [] synonym: "starch formation" EXACT [] synonym: "starch synthesis" EXACT [] xref: MetaCyc:PWY-622 is_a: GO:0005982 ! starch metabolic process is_a: GO:0009250 ! glucan biosynthetic process intersection_of: GO:0009058 ! biosynthetic process intersection_of: RO:0004008 CHEBI:28017 ! has primary output relationship: RO:0004008 CHEBI:28017 ! has primary output [Term] id: GO:0019318 name: hexose metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a hexose, any monosaccharide with a chain of six carbon atoms in the molecule." [ISBN:0198506732] synonym: "hexose metabolism" EXACT [] is_a: GO:0005996 ! monosaccharide metabolic process intersection_of: GO:0008152 ! metabolic process intersection_of: RO:0004007 CHEBI:18133 ! has primary input or output relationship: RO:0004007 CHEBI:18133 ! has primary input or output [Term] id: GO:0019319 name: hexose biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of hexose, any monosaccharide with a chain of six carbon atoms in the molecule." [ISBN:0198506732] synonym: "hexose anabolism" EXACT [] synonym: "hexose biosynthesis" EXACT [] synonym: "hexose formation" EXACT [] synonym: "hexose synthesis" EXACT [] is_a: GO:0019318 ! hexose metabolic process is_a: GO:0046364 ! monosaccharide biosynthetic process intersection_of: GO:0009058 ! biosynthetic process intersection_of: RO:0004008 CHEBI:18133 ! has primary output relationship: RO:0004008 CHEBI:18133 ! has primary output [Term] id: GO:0019320 name: hexose catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of hexose, any monosaccharide with a chain of six carbon atoms in the molecule." [ISBN:0198506732] synonym: "hexose breakdown" EXACT [] synonym: "hexose catabolism" EXACT [] synonym: "hexose degradation" EXACT [] is_a: GO:0019318 ! hexose metabolic process is_a: GO:0046365 ! monosaccharide catabolic process intersection_of: GO:0009056 ! catabolic process intersection_of: RO:0004009 CHEBI:18133 ! has primary input relationship: RO:0004009 CHEBI:18133 ! has primary input [Term] id: GO:0019336 name: phenol-containing compound catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of a phenol, any compound containing one or more hydroxyl groups directly attached to an aromatic carbon ring." [ISBN:0198506732] synonym: "phenol-containing compound breakdown" EXACT [] synonym: "phenol-containing compound catabolism" EXACT [] synonym: "phenol-containing compound degradation" EXACT [] xref: MetaCyc:PHENOLDEG-PWY is_a: GO:0009056 ! catabolic process is_a: GO:0018958 ! phenol-containing compound metabolic process intersection_of: GO:0009056 ! catabolic process intersection_of: RO:0004009 CHEBI:33853 ! has primary input relationship: RO:0004009 CHEBI:33853 ! has primary input [Term] id: GO:0019377 name: glycolipid catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of glycolipid, a class of 1,2-di-O-acylglycerols joined at oxygen 3 by a glycosidic linkage to a carbohydrate part (usually a mono-, di- or tri-saccharide)." [GOC:go_curators] synonym: "glycolipid breakdown" EXACT [] synonym: "glycolipid catabolism" EXACT [] synonym: "glycolipid degradation" EXACT [] is_a: GO:0006664 ! glycolipid metabolic process is_a: GO:0046466 ! membrane lipid catabolic process is_a: GO:1901136 ! carbohydrate derivative catabolic process intersection_of: GO:0009056 ! catabolic process intersection_of: RO:0004009 CHEBI:33563 ! has primary input relationship: RO:0004009 CHEBI:33563 ! has primary input [Term] id: GO:0019464 name: glycine decarboxylation via glycine cleavage system namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of glycine by oxidative cleavage to carbon dioxide, ammonia, and a methylene group, mediated by enzymes of the glycine cleavage complex." [MetaCyc:GLYCLEAV-PWY] synonym: "glycine cleavage system" BROAD [] xref: MetaCyc:GLYCLEAV-PWY is_a: GO:0006546 ! glycine catabolic process intersection_of: GO:0009056 ! catabolic process intersection_of: RO:0004008 CHEBI:28938 ! has primary output intersection_of: RO:0004009 CHEBI:57305 ! has primary input relationship: RO:0004008 CHEBI:28938 ! has primary output property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/30202" xsd:anyURI [Term] id: GO:0019538 name: protein metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a protein. Includes protein modification." [GOC:ma] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_annotate subset: goslim_agr subset: goslim_flybase_ribbon subset: goslim_mouse subset: goslim_pir subset: goslim_plant subset: goslim_plant_ribbon synonym: "cellular protein metabolic process" EXACT [] synonym: "cellular protein metabolism" EXACT [] synonym: "multicellular organismal protein metabolic process" NARROW [] synonym: "protein metabolic process and modification" EXACT [] synonym: "protein metabolism" EXACT [] synonym: "protein metabolism and modification" EXACT [] xref: Reactome:R-HSA-392499 "Metabolism of proteins" xref: Wikipedia:Protein_metabolism is_a: GO:0043170 ! macromolecule metabolic process is_a: GO:0044238 ! primary metabolic process intersection_of: GO:0008152 ! metabolic process intersection_of: RO:0004007 PR:000000001 ! has primary input or output protein relationship: RO:0004007 PR:000000001 ! has primary input or output protein property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/23112" xsd:anyURI property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/27189" xsd:anyURI [Term] id: GO:0019614 name: catechol-containing compound catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of catechol-containing compounds. Catechol is a compound containing a pyrocatechol nucleus or substituent." [GOC:go_curators] synonym: "catechol breakdown" RELATED [] synonym: "catechol catabolic process" RELATED [] synonym: "catechol catabolism" RELATED [] synonym: "catechol degradation" RELATED [] is_a: GO:0009712 ! catechol-containing compound metabolic process is_a: GO:0019336 ! phenol-containing compound catabolic process intersection_of: GO:0009056 ! catabolic process intersection_of: RO:0004009 CHEBI:33566 ! has primary input relationship: RO:0004009 CHEBI:33566 ! has primary input [Term] id: GO:0019626 name: short-chain fatty acid catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of a short-chain fatty acid. A short-chain fatty acid has an aliphatic tail containing fewer than 6 carbons." [ISBN:0198506732] comment: While there is not universal consensus on the lengths of short-, medium-, long- and very-long-chain fatty acids, the GO uses the definitions in ChEBI (see CHEBI:26666, CHEBI:59554, CHEBI:15904 and CHEBI:27283). synonym: "short-chain fatty acid breakdown" EXACT [] synonym: "short-chain fatty acid catabolism" EXACT [] synonym: "short-chain fatty acid degradation" EXACT [] xref: MetaCyc:ACETOACETATE-DEG-PWY xref: Reactome:R-HSA-71032 "Propionyl-CoA catabolism" is_a: GO:0009062 ! fatty acid catabolic process is_a: GO:0046459 ! short-chain fatty acid metabolic process intersection_of: GO:0009056 ! catabolic process intersection_of: RO:0004009 CHEBI:58951 ! has primary input relationship: RO:0004009 CHEBI:58951 ! has primary input property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/26445" xsd:anyURI [Term] id: GO:0019637 name: organophosphate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving organophosphates, any phosphate-containing organic compound." [ISBN:0198506732] subset: goslim_pombe synonym: "organophosphate metabolism" EXACT [] is_a: GO:0006793 ! phosphorus metabolic process intersection_of: GO:0008152 ! metabolic process intersection_of: RO:0004007 CHEBI:25710 ! has primary input or output relationship: RO:0004007 CHEBI:25710 ! has primary input or output property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/26992" xsd:anyURI [Term] id: GO:0019693 name: ribose phosphate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving ribose phosphate, any phosphorylated ribose sugar." [GOC:ai] synonym: "ribose phosphate metabolism" EXACT [] is_a: GO:0006796 ! phosphate-containing compound metabolic process is_a: GO:0019637 ! organophosphate metabolic process is_a: GO:1901135 ! carbohydrate derivative metabolic process intersection_of: GO:0008152 ! metabolic process intersection_of: RO:0004007 CHEBI:26562 ! has primary input or output relationship: RO:0004007 CHEBI:26562 ! has primary input or output [Term] id: GO:0019722 name: calcium-mediated signaling namespace: biological_process def: "Any intracellular signal transduction in which the signal is passed on within the cell via calcium ions." [GOC:signaling] synonym: "calcium ion signaling" EXACT [] synonym: "calcium signaling" EXACT [] synonym: "calcium signalling" EXACT [] synonym: "calcium-mediated signalling" EXACT [] xref: Wikipedia:Calcium_signaling is_a: GO:0141124 ! intracellular signaling cassette [Term] id: GO:0019724 name: B cell mediated immunity namespace: biological_process def: "Any process involved with the carrying out of an immune response by a B cell, through, for instance, the production of antibodies or cytokines, or antigen presentation to T cells." [GO_REF:0000022, GOC:add, ISBN:0781735149] synonym: "B lymphocyte mediated immune effector process" EXACT [] synonym: "B lymphocyte mediated immunity" EXACT [] synonym: "B-cell mediated immune effector process" EXACT [] synonym: "B-cell mediated immunity" EXACT [] synonym: "B-lymphocyte mediated immune effector process" EXACT [] synonym: "B-lymphocyte mediated immunity" EXACT [] is_a: GO:0002449 ! lymphocyte mediated immunity is_a: GO:0002460 ! adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains intersection_of: GO:0002376 ! immune system process intersection_of: RO:0002608 CL:0000236 ! process has causal agent B cell relationship: RO:0002608 CL:0000236 ! process has causal agent B cell [Term] id: GO:0019725 name: cellular homeostasis namespace: biological_process def: "Any process involved in the maintenance of an internal steady state at the level of the cell." [GOC:isa_complete, GOC:jl, ISBN:0395825172] subset: goslim_candida subset: goslim_euk_cellular_processes_ribbon subset: goslim_plant is_a: BFO:0000003 is_a: GO:0042592 ! homeostatic process intersection_of: GO:0042592 ! homeostatic process intersection_of: BFO:0000066 CL:0000000 ! occurs in cell disjoint_from: GO:0048872 ! homeostasis of number of cells relationship: BFO:0000066 CL:0000000 ! occurs in cell relationship: RO:0002162 NCBITaxon:131567 ! in taxon cellular organisms [Term] id: GO:0019730 name: antimicrobial humoral response namespace: biological_process def: "An immune response against microbes mediated through a body fluid. Examples of this process are seen in the antimicrobial humoral response of Drosophila melanogaster and Mus musculus." [GOC:go_curators, GOC:mtg_sensu] xref: Reactome:R-HSA-6803157 "Antimicrobial peptides" is_a: GO:0006959 ! humoral immune response is_a: GO:0140546 ! defense response to symbiont property_value: RO:0002161 NCBITaxon:4895 [Term] id: GO:0019747 name: regulation of isoprenoid metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving isoprenoids." [GOC:go_curators] synonym: "regulation of isoprenoid metabolism" EXACT [] is_a: GO:0019216 ! regulation of lipid metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0006720 ! regulates isoprenoid metabolic process relationship: RO:0002211 GO:0006720 ! regulates isoprenoid metabolic process [Term] id: GO:0019750 name: chloroplast localization namespace: biological_process def: "Any process in which a chloroplast is transported to, and/or maintained in, a specific location within the cell. A chloroplast is a chlorophyll-containing plastid found in cells of algae and higher plants." [GOC:bf, GOC:jl, ISBN:0198506732] synonym: "chloroplast localisation" EXACT [GOC:mah] is_a: GO:0051644 ! plastid localization intersection_of: GO:0051179 ! localization intersection_of: RO:0004009 GO:0009507 ! has primary input chloroplast relationship: RO:0004009 GO:0009507 ! has primary input chloroplast property_value: RO:0002161 NCBITaxon:28009 property_value: RO:0002161 NCBITaxon:33208 property_value: RO:0002161 NCBITaxon:4751 property_value: RO:0002161 NCBITaxon:554915 [Term] id: GO:0019752 name: carboxylic acid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving carboxylic acids, any organic acid containing one or more carboxyl (COOH) groups or anions (COO-)." [ISBN:0198506732] synonym: "carboxylic acid metabolism" EXACT [] xref: Reactome:R-HSA-389661 "Glyoxylate metabolism and glycine degradation" is_a: GO:0043436 ! oxoacid metabolic process intersection_of: GO:0008152 ! metabolic process intersection_of: RO:0004007 CHEBI:29067 ! has primary input or output relationship: RO:0004007 CHEBI:29067 ! has primary input or output [Term] id: GO:0019814 name: immunoglobulin complex namespace: cellular_component def: "A protein complex that in its canonical form is composed of two identical immunoglobulin heavy chains and two identical immunoglobulin light chains, held together by disulfide bonds and sometimes complexed with additional proteins. An immunoglobulin complex may be embedded in the plasma membrane or present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph." [GOC:add, GOC:jl, ISBN:0781765196] comment: Note that an immunoglobulin complex has the function of antigen binding if a suitable antigen is available. subset: goslim_pir synonym: "antibody" NARROW [] is_a: GO:0032991 ! protein-containing complex [Term] id: GO:0019815 name: B cell receptor complex namespace: cellular_component def: "An immunoglobulin complex that is present in the plasma membrane of B cells and that in its canonical form is composed of two identical immunoglobulin heavy chains and two identical immunoglobulin light chains and a signaling subunit, a heterodimer of the Ig-alpha and Ig-beta proteins." [GOC:add, ISBN:0781735149] comment: Note that an immunoglobulin complex has the function of antigen binding if a suitable antigen is available. synonym: "antibody" RELATED [GOC:mah] synonym: "B cell receptor accessory molecule complex" RELATED [] synonym: "B lymphocyte receptor complex" EXACT [] synonym: "B-cell receptor complex" EXACT [] synonym: "B-lymphocyte receptor complex" EXACT [] synonym: "BCR complex" EXACT [] synonym: "immunoglobulin complex, membrane bound" EXACT [] is_a: GO:0019814 ! immunoglobulin complex is_a: GO:0098802 ! plasma membrane signaling receptor complex [Term] id: GO:0019825 name: oxygen binding namespace: molecular_function def: "Binding to oxygen (O2)." [GOC:jl] subset: goslim_pir subset: goslim_plant synonym: "cytochrome P450" NARROW [] synonym: "cytochrome P450 activity" RELATED [] is_a: BFO:0000003 is_a: GO:0036094 ! small molecule binding intersection_of: GO:0005488 ! binding intersection_of: RO:0004009 CHEBI:15379 ! has primary input relationship: RO:0004009 CHEBI:15379 ! has primary input [Term] id: GO:0019827 name: stem cell population maintenance namespace: biological_process def: "The process by which an organism or tissue maintains a population of stem cells of a single type. This can be achieved by a number of mechanisms: stem cell asymmetric division maintains stem cell numbers; stem cell symmetric division increases them; maintenance of a stem cell niche maintains the conditions for commitment to the stem cell fate for some types of stem cell; stem cells may arise de novo from other cell types." [GOC:mah, ISBN:0878932437] synonym: "maintenance of pluripotency" RELATED [GOC:vk] is_a: BFO:0000003 is_a: GO:0032501 ! multicellular organismal process is_a: GO:0098727 ! maintenance of cell number intersection_of: GO:0098727 ! maintenance of cell number intersection_of: RO:0012003 CL:0000034 ! acts on population of stem cell relationship: RO:0012003 CL:0000034 ! acts on population of stem cell property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0019840 name: isoprenoid binding namespace: molecular_function def: "Binding to an isoprenoid compound, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues." [GOC:jl] subset: goslim_pir is_a: GO:0008289 ! lipid binding intersection_of: GO:0005488 ! binding intersection_of: RO:0004009 CHEBI:24913 ! has primary input relationship: RO:0004009 CHEBI:24913 ! has primary input [Term] id: GO:0019865 name: immunoglobulin binding namespace: molecular_function def: "Binding to an immunoglobulin." [GOC:ma] is_a: GO:0044877 ! protein-containing complex binding intersection_of: GO:0005488 ! binding intersection_of: RO:0004009 GO:0019814 ! has primary input immunoglobulin complex relationship: RO:0004009 GO:0019814 ! has primary input immunoglobulin complex [Term] id: GO:0019867 name: outer membrane namespace: cellular_component def: "The external membrane of Gram-negative bacteria or certain organelles such as mitochondria and chloroplasts; freely permeable to most ions and metabolites." [GOC:go_curators] subset: goslim_metagenomics is_a: GO:0016020 ! membrane [Term] id: GO:0019882 name: antigen processing and presentation namespace: biological_process def: "The process in which an antigen-presenting cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex." [GO_REF:0000022, GOC:add, ISBN:0781735149, PMID:15771591, PMID:15928678] synonym: "antigen presentation" EXACT [] synonym: "antigen processing" EXACT [] xref: Wikipedia:Antigen_presentation is_a: GO:0002376 ! immune system process property_value: RO:0002161 NCBITaxon:4895 [Term] id: GO:0019883 name: antigen processing and presentation of endogenous antigen namespace: biological_process def: "The process in which an antigen-presenting cell expresses antigen (peptide or lipid) of endogenous origin on its cell surface in association with an MHC protein complex." [GOC:add, ISBN:0781735149, PMID:15771591, PMID:15928678] synonym: "antigen presentation, endogenous antigen" EXACT [] is_a: GO:0019882 ! antigen processing and presentation property_value: RO:0002161 NCBITaxon:4895 [Term] id: GO:0019884 name: antigen processing and presentation of exogenous antigen namespace: biological_process def: "The process in which an antigen-presenting cell expresses antigen (peptide or lipid) of exogenous origin on its cell surface in association with an MHC protein complex." [GOC:add, ISBN:0781735149, PMID:15771591, PMID:15928678] synonym: "antigen presentation, exogenous antigen" EXACT [] is_a: GO:0019882 ! antigen processing and presentation property_value: RO:0002161 NCBITaxon:4895 [Term] id: GO:0019896 name: axonal transport of mitochondrion namespace: biological_process def: "The directed movement of mitochondria along microtubules in nerve cell axons." [GOC:ai] subset: goslim_synapse synonym: "axon transport of mitochondria" EXACT [] is_a: GO:0047497 ! mitochondrion transport along microtubule is_a: GO:0098930 ! axonal transport intersection_of: GO:0006810 ! transport intersection_of: BFO:0000066 GO:1904115 ! occurs in axon cytoplasm intersection_of: RO:0002341 GO:0005874 ! results in transport along microtubule intersection_of: RO:0004009 GO:0005739 ! has primary input mitochondrion relationship: BFO:0000066 GO:1904115 ! occurs in axon cytoplasm [Term] id: GO:0019953 name: sexual reproduction namespace: biological_process def: "A type of reproduction that combines the genetic material of two gametes (such as a sperm or egg cell or fungal spores). The gametes have an haploid genome (with a single set of chromosomes, the product of a meiotic division) and combines with one another to produce a zygote (diploid)." [Wikipedia:Sexual_reproduction] comment: Note that gametes may come from two organisms or from a single organism in the case of self-fertilizing hermaphrodites, e.g. C. elegans, or self-fertilization in plants. Note also that sexual reproduction may be seen as the regular alternation, in the life cycle of haplontic, diplontic and diplohaplontic organisms, of meiosis and fertilization which provides for the production offspring. In diplontic organisms there is a life cycle in which the products of meiosis behave directly as gametes, fusing to form a zygote from which the diploid, or sexually reproductive polyploid, adult organism will develop. In diplohaplontic organisms a haploid phase (gametophyte) exists in the life cycle between meiosis and fertilization (e.g. higher plants, many algae and Fungi); the products of meiosis are spores that develop as haploid individuals from which haploid gametes develop to form a diploid zygote; diplohaplontic organisms show an alternation of haploid and diploid generations. In haplontic organisms meiosis occurs in the zygote, giving rise to four haploid cells (e.g. many algae and protozoa), only the zygote is diploid and this may form a resistant spore, tiding organisms over hard times. subset: gocheck_do_not_annotate xref: Wikipedia:Sexual_reproduction is_a: GO:0022414 ! reproductive process property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/22929" xsd:anyURI [Term] id: GO:0019955 name: cytokine binding namespace: molecular_function def: "Binding to a cytokine, any of a group of proteins that function to control the survival, growth and differentiation of tissues and cells, and which have autocrine and paracrine activity." [GOC:ai, GOC:bf, ISBN:0198599471] synonym: "IL binding" NARROW [] synonym: "interleukin binding" NARROW [] is_a: GO:0005515 ! protein binding property_value: RO:0002161 NCBITaxon:4751 [Term] id: GO:0021501 name: prechordal plate formation namespace: biological_process def: "The formation of the prechordal plate. The prechordal plate is a thickening of the endoderm at the cranial end of the primitive streak formed by the involution of Spemann's organizer cells. The prechordal plate and the notochord induce the formation of the neural plate from the overlying ectodermal cells." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid] is_a: BFO:0000003 is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0003063 ! results in formation of anatomical entity prechordal plate relationship: BFO:0000050 GO:0007399 ! part of nervous system development relationship: RO:0002297 UBERON:0003063 ! results in formation of anatomical entity prechordal plate [Term] id: GO:0021508 name: floor plate formation namespace: biological_process def: "The formation of a ventral region of glial cells in the neural tube that provides inductive signals for the specification of neuronal cell types. The floor plate is evident at the ventral midline by the neural fold stage." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:11262869] is_a: BFO:0000003 is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0003079 ! results in formation of anatomical entity floor plate relationship: BFO:0000050 GO:0007418 ! part of ventral midline development relationship: BFO:0000050 GO:0033505 ! part of floor plate morphogenesis relationship: RO:0002297 UBERON:0003079 ! results in formation of anatomical entity floor plate [Term] id: GO:0021509 name: roof plate formation namespace: biological_process def: "The formation of a single row of glia at the dorsal midline of the developing neural tube. This region provides inductive signals for the specification of neuronal cell types and of the specification of neural crest cells. The cells comprising the roof plate are the precursors to radial glial cells." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:15936325] is_a: BFO:0000003 is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0003054 ! results in formation of anatomical entity roof plate relationship: BFO:0000050 GO:0001841 ! part of neural tube formation relationship: RO:0002297 UBERON:0003054 ! results in formation of anatomical entity roof plate [Term] id: GO:0021510 name: spinal cord development namespace: biological_process def: "The process whose specific outcome is the progression of the spinal cord over time, from its formation to the mature structure. The spinal cord primarily conducts sensory and motor nerve impulses between the brain and the peripheral nervous tissues." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid] is_a: GO:0048856 ! anatomical structure development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0002240 ! results in development of spinal cord relationship: BFO:0000050 GO:0007417 ! part of central nervous system development relationship: RO:0002162 NCBITaxon:89593 ! in taxon Craniata relationship: RO:0002296 UBERON:0002240 ! results in development of spinal cord [Term] id: GO:0021514 name: ventral spinal cord interneuron differentiation namespace: biological_process def: "The process in which neuroepithelial cells in the neural tube acquire specialized structural and/or functional features of ventral spinal cord interneurons. Ventral spinal cord interneurons are cells located in the ventral portion of the spinal cord that transmit signals between sensory and motor neurons and are required for reflexive responses. Differentiation includes the processes involved in commitment of a cell to a specific fate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:11262869] is_a: GO:0021515 ! cell differentiation in spinal cord is_a: GO:0021953 ! central nervous system neuron differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: BFO:0000066 UBERON:0002240 ! occurs in spinal cord intersection_of: RO:0002315 CL:0000099 ! results in acquisition of features of interneuron relationship: BFO:0000050 GO:0021517 ! part of ventral spinal cord development relationship: RO:0002315 CL:0000099 ! results in acquisition of features of interneuron [Term] id: GO:0021515 name: cell differentiation in spinal cord namespace: biological_process def: "The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the cells of the spinal cord. Differentiation includes the processes involved in commitment of a cell to a specific fate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:11262869] is_a: GO:0030154 ! cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: BFO:0000066 UBERON:0002240 ! occurs in spinal cord relationship: BFO:0000050 GO:0021510 ! part of spinal cord development relationship: BFO:0000066 UBERON:0002240 ! occurs in spinal cord [Term] id: GO:0021516 name: dorsal spinal cord development namespace: biological_process def: "The process whose specific outcome is the progression of the dorsal region of the spinal cord over time, from its formation to the mature structure. The dorsal region of the mature spinal cord contains neurons that process and relay sensory input." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:11179871] is_a: GO:0048856 ! anatomical structure development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0002256 ! results in development of dorsal horn of spinal cord relationship: BFO:0000050 GO:0021510 ! part of spinal cord development relationship: RO:0002296 UBERON:0002256 ! results in development of dorsal horn of spinal cord [Term] id: GO:0021517 name: ventral spinal cord development namespace: biological_process def: "The process whose specific outcome is the progression of the ventral region of the spinal cord over time, from its formation to the mature structure. The neurons of the ventral region of the mature spinal cord participate in motor output." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid] is_a: GO:0048856 ! anatomical structure development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0002257 ! results in development of ventral horn of spinal cord relationship: BFO:0000050 GO:0021510 ! part of spinal cord development relationship: RO:0002296 UBERON:0002257 ! results in development of ventral horn of spinal cord [Term] id: GO:0021522 name: spinal cord motor neuron differentiation namespace: biological_process def: "The process in which neuroepithelial cells in the ventral neural tube acquire specialized structural and/or functional features of motor neurons. Motor neurons innervate an effector (muscle or glandular) tissue and are responsible for transmission of motor impulses from the brain to the periphery. Differentiation includes the processes involved in commitment of a cell to a specific fate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:11262869] is_a: GO:0021515 ! cell differentiation in spinal cord is_a: GO:0021953 ! central nervous system neuron differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0011001 ! results in acquisition of features of spinal cord motor neuron relationship: BFO:0000050 GO:0021517 ! part of ventral spinal cord development relationship: RO:0002315 CL:0011001 ! results in acquisition of features of spinal cord motor neuron [Term] id: GO:0021523 name: somatic motor neuron differentiation namespace: biological_process def: "The process in which neuroepithelial cells in the neural tube acquire specialized structural and/or functional features of somatic motor neurons. Somatic motor neurons innervate skeletal muscle targets and are responsible for transmission of motor impulses from the brain to the periphery. Differentiation includes the processes involved in commitment of a cell to a specific fate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:11262869] is_a: GO:0021522 ! spinal cord motor neuron differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0005024 ! results in acquisition of features of somatomotor neuron relationship: RO:0002315 CL:0005024 ! results in acquisition of features of somatomotor neuron [Term] id: GO:0021525 name: lateral motor column neuron differentiation namespace: biological_process def: "The process in which differentiating motor neurons in the neural tube acquire the specialized structural and/or functional features of lateral motor column neurons. Lateral motor column neurons are generated only on limb levels and send axons into the limb mesenchyme. Differentiation includes the processes involved in commitment of a cell to a specific fate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:11262869] is_a: GO:0021522 ! spinal cord motor neuron differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0011002 ! results in acquisition of features of lateral motor column neuron relationship: BFO:0000050 GO:0021523 ! part of somatic motor neuron differentiation relationship: RO:0002315 CL:0011002 ! results in acquisition of features of lateral motor column neuron [Term] id: GO:0021531 name: spinal cord radial glial cell differentiation namespace: biological_process def: "The process in which neuroepithelial cells in the ventral neural tube acquire specialized structural and/or functional features of radial glial cells. Radial cell precursors differentiate into both neuronal cell types and mature radial glial cells. Mature radial glial cells regulate the axon growth and pathfinding processes that occur during white matter patterning of the developing spinal cord. Differentiation includes the processes involved in commitment of a cell to a specific fate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:16185248] synonym: "radial glial cell differentiation in spinal cord" EXACT [] is_a: GO:0021515 ! cell differentiation in spinal cord is_a: GO:0060019 ! radial glial cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:1000073 ! results in acquisition of features of spinal cord radial glial cell relationship: RO:0002315 CL:1000073 ! results in acquisition of features of spinal cord radial glial cell [Term] id: GO:0021532 name: neural tube patterning namespace: biological_process def: "The regionalization process that regulates the coordinated growth that establishes the non-random spatial arrangement of the neural tube." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid] is_a: GO:0003002 ! regionalization relationship: BFO:0000050 GO:0021915 ! part of neural tube development [Term] id: GO:0021533 name: cell differentiation in hindbrain namespace: biological_process def: "The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the mature cells of the hindbrain. Differentiation includes the processes involved in commitment of a cell to a specific fate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid] is_a: GO:0030154 ! cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: BFO:0000066 UBERON:0002028 ! occurs in hindbrain relationship: BFO:0000050 GO:0030902 ! part of hindbrain development relationship: BFO:0000066 UBERON:0002028 ! occurs in hindbrain [Term] id: GO:0021534 name: cell proliferation in hindbrain namespace: biological_process def: "The multiplication or reproduction of cells, resulting in the expansion of a cell population in the hindbrain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid] is_a: BFO:0000003 is_a: GO:0061351 ! neural precursor cell proliferation intersection_of: GO:0008283 ! cell population proliferation intersection_of: BFO:0000066 UBERON:0002028 ! occurs in hindbrain relationship: BFO:0000050 GO:0030902 ! part of hindbrain development relationship: BFO:0000066 UBERON:0002028 ! occurs in hindbrain [Term] id: GO:0021535 name: cell migration in hindbrain namespace: biological_process def: "The orderly movement of a cell that will reside in the hindbrain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid] is_a: BFO:0000003 is_a: GO:0016477 ! cell migration intersection_of: GO:0016477 ! cell migration intersection_of: BFO:0000066 UBERON:0002028 ! occurs in hindbrain relationship: BFO:0000050 GO:0030902 ! part of hindbrain development relationship: BFO:0000066 UBERON:0002028 ! occurs in hindbrain [Term] id: GO:0021536 name: diencephalon development namespace: biological_process def: "The process whose specific outcome is the progression of the diencephalon over time, from its formation to the mature structure. The diencephalon is the paired caudal parts of the prosencephalon from which the thalamus, hypothalamus, epithalamus and subthalamus are derived; these regions regulate autonomic, visceral and endocrine function, and process information directed to the cerebral cortex." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] is_a: GO:0048856 ! anatomical structure development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0001894 ! results in development of diencephalon relationship: BFO:0000050 GO:0030900 ! part of forebrain development relationship: RO:0002162 NCBITaxon:89593 ! in taxon Craniata relationship: RO:0002296 UBERON:0001894 ! results in development of diencephalon [Term] id: GO:0021537 name: telencephalon development namespace: biological_process def: "The process whose specific outcome is the progression of the telencephalon over time, from its formation to the mature structure. The telencephalon is the paired anteriolateral division of the prosencephalon plus the lamina terminalis from which the olfactory lobes, cerebral cortex, and subcortical nuclei are derived." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:12626695] synonym: "cerebrum development" EXACT [GOC:sl, PMID:22331407] is_a: GO:0048856 ! anatomical structure development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0001893 ! results in development of telencephalon relationship: BFO:0000050 GO:0030900 ! part of forebrain development relationship: RO:0002296 UBERON:0001893 ! results in development of telencephalon [Term] id: GO:0021538 name: epithalamus development namespace: biological_process def: "The progression of the epithalamus over time from its initial formation until its mature state. The epithalamus is the small dorsomedial area of the thalamus including the habenular nuclei and associated fiber bundles, the pineal body, and the epithelial roof of the third ventricle." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] is_a: GO:0048856 ! anatomical structure development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0001899 ! results in development of epithalamus relationship: BFO:0000050 GO:0021536 ! part of diencephalon development relationship: RO:0002296 UBERON:0001899 ! results in development of epithalamus [Term] id: GO:0021539 name: subthalamus development namespace: biological_process def: "The process whose specific outcome is the progression of the subthalamus over time, from its formation to the mature structure. The subthalamus is the anterior part of the diencephalon that lies between the thalamus, hypothalamus, and tegmentum of the mesencephalon, including subthalamic nucleus, zona incerta, the fields of Forel, and the nucleus of ansa lenticularis." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] synonym: "ventral thalamus development" RELATED [GOC:cls] is_a: GO:0048856 ! anatomical structure development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0001900 ! results in development of ventral thalamus relationship: BFO:0000050 GO:0021536 ! part of diencephalon development relationship: RO:0002296 UBERON:0001900 ! results in development of ventral thalamus [Term] id: GO:0021540 name: corpus callosum morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the corpus callosum are generated and organized. The corpus callosum is a thick bundle of nerve fibers comprising a commissural plate connecting the two cerebral hemispheres. It consists of contralateral axon projections that provides communications between the right and left cerebral hemispheres." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] is_a: GO:0021952 ! central nervous system projection neuron axonogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0002336 ! results in morphogenesis of corpus callosum relationship: BFO:0000050 GO:0022038 ! part of corpus callosum development relationship: RO:0002298 UBERON:0002336 ! results in morphogenesis of corpus callosum [Term] id: GO:0021541 name: ammon gyrus development namespace: biological_process def: "The process whose specific outcome is the progression of the ammon gyrus over time, from its formation to the mature structure. The ammon gyrus, often subdivided into the CA1 and CA3 regions, is one of the two interlocking gyri of the hippocampus that is rich in large pyramidal neurons." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] synonym: "Ammon's horn development" RELATED [GOC:cls] synonym: "cornu ammonis development" RELATED [GOC:cls] is_a: GO:0048856 ! anatomical structure development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0001954 ! results in development of Ammon's horn relationship: BFO:0000050 GO:0021766 ! part of hippocampus development relationship: RO:0002296 UBERON:0001954 ! results in development of Ammon's horn [Term] id: GO:0021542 name: dentate gyrus development namespace: biological_process def: "The process whose specific outcome is the progression of the dentate gyrus over time, from its formation to the mature structure. The dentate gyrus is one of two interlocking gyri of the hippocampus. It contains granule cells, which project to the pyramidal cells and interneurons of the CA3 region of the ammon gyrus." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] is_a: GO:0048856 ! anatomical structure development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0001885 ! results in development of dentate gyrus of hippocampal formation relationship: BFO:0000050 GO:0021766 ! part of hippocampus development relationship: RO:0002296 UBERON:0001885 ! results in development of dentate gyrus of hippocampal formation [Term] id: GO:0021543 name: pallium development namespace: biological_process def: "The process whose specific outcome is the progression of the pallium over time, from its formation to the mature structure. The pallium is the roof region of the telencephalon." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:12626695] is_a: GO:0048856 ! anatomical structure development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0000203 ! results in development of pallium relationship: BFO:0000050 GO:0021537 ! part of telencephalon development relationship: RO:0002296 UBERON:0000203 ! results in development of pallium [Term] id: GO:0021544 name: subpallium development namespace: biological_process def: "The process whose specific outcome is the progression of the subpallium over time, from its formation to the mature structure. The subpallium is the base region of the telencephalon." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:12626695] is_a: GO:0048856 ! anatomical structure development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0000204 ! results in development of ventral part of telencephalon relationship: BFO:0000050 GO:0021537 ! part of telencephalon development relationship: RO:0002296 UBERON:0000204 ! results in development of ventral part of telencephalon [Term] id: GO:0021545 name: cranial nerve development namespace: biological_process def: "The process whose specific outcome is the progression of the cranial nerves over time, from its formation to the mature structure. The cranial nerves are composed of twelve pairs of nerves that emanate from the nervous tissue of the hindbrain. These nerves are sensory, motor, or mixed in nature, and provide the motor and general sensory innervation of the head, neck and viscera. They mediate vision, hearing, olfaction and taste and carry the parasympathetic innervation of the autonomic ganglia that control visceral functions." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] is_a: GO:0021675 ! nerve development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0001785 ! results in development of cranial nerve relationship: RO:0002296 UBERON:0001785 ! results in development of cranial nerve [Term] id: GO:0021546 name: rhombomere development namespace: biological_process def: "The process whose specific outcome is the progression of the rhombomere over time, from its formation to the mature structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] is_a: GO:0048856 ! anatomical structure development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0001892 ! results in development of rhombomere relationship: BFO:0000050 GO:0030902 ! part of hindbrain development relationship: RO:0002296 UBERON:0001892 ! results in development of rhombomere [Term] id: GO:0021547 name: midbrain-hindbrain boundary initiation namespace: biological_process def: "The regionalization process that gives rise to the midbrain-hindbrain boundary. The midbrain-hindbrain domain of the embryonic brain is comprised of the mesencephalic vesicle and the first rhombencephalic vesicle at early somitogenesis stages. An organizing center at the boundary patterns the midbrain and hindbrain primordia of the neural plate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:isa_complete, GOC:jid, PMID:15541513] synonym: "isthmus biosynthesis" RELATED [GOC:cls] synonym: "isthmus formation" RELATED [GOC:cls] synonym: "MHB biosynthesis" EXACT [GOC:cls] synonym: "MHB formation" EXACT [GOC:cls] synonym: "midbrain-hindbrain boundary biosynthesis" EXACT [GOC:cls] synonym: "midbrain-hindbrain boundary formation" EXACT [GOC:cls] is_a: GO:0003002 ! regionalization is_a: GO:0048859 ! formation of anatomical boundary intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0003052 ! results in formation of anatomical entity midbrain-hindbrain boundary relationship: BFO:0000050 GO:0021999 ! part of neural plate anterior/posterior regionalization relationship: BFO:0000050 GO:0030917 ! part of midbrain-hindbrain boundary development relationship: RO:0002297 UBERON:0003052 ! results in formation of anatomical entity midbrain-hindbrain boundary [Term] id: GO:0021548 name: pons development namespace: biological_process def: "The process whose specific outcome is the progression of the pons over time, from its formation to the mature structure. The pons lies above the medulla and next to the cerebellum. The pons conveys information about movement from the cerebral hemisphere to the cerebellum." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] is_a: GO:0048856 ! anatomical structure development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0000988 ! results in development of pons relationship: BFO:0000050 GO:0022037 ! part of metencephalon development relationship: RO:0002296 UBERON:0000988 ! results in development of pons [Term] id: GO:0021549 name: cerebellum development namespace: biological_process def: "The process whose specific outcome is the progression of the cerebellum over time, from its formation to the mature structure. The cerebellum is the portion of the brain in the back of the head between the cerebrum and the pons. In mice, the cerebellum controls balance for walking and standing, modulates the force and range of movement and is involved in the learning of motor skills." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] is_a: GO:0048856 ! anatomical structure development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0002037 ! results in development of cerebellum relationship: BFO:0000050 GO:0022037 ! part of metencephalon development relationship: RO:0002296 UBERON:0002037 ! results in development of cerebellum [Term] id: GO:0021550 name: medulla oblongata development namespace: biological_process def: "The process whose specific outcome is the progression of the medulla oblongata over time, from its formation to the mature structure. The medulla oblongata lies directly above the spinal cord and controls vital autonomic functions such as digestion, breathing and the control of heart rate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] synonym: "medulla development" RELATED [GOC:cls] synonym: "myelencephalon development" RELATED [GOC:cls] is_a: GO:0048856 ! anatomical structure development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0001896 ! results in development of medulla oblongata relationship: BFO:0000050 GO:0030902 ! part of hindbrain development relationship: RO:0002296 UBERON:0001896 ! results in development of medulla oblongata [Term] id: GO:0021551 name: central nervous system morphogenesis namespace: biological_process def: "The process in which the anatomical structure of the central nervous system is generated and organized. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain and spinal cord. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0582227089] is_a: BFO:0000003 is_a: GO:0009653 ! anatomical structure morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0001017 ! results in morphogenesis of central nervous system relationship: BFO:0000050 GO:0007417 ! part of central nervous system development relationship: RO:0002298 UBERON:0001017 ! results in morphogenesis of central nervous system [Term] id: GO:0021553 name: olfactory nerve development namespace: biological_process def: "The process whose specific outcome is the progression of the olfactory nerve over time, from its formation to the mature structure. The olfactory nerve is a collection of sensory nerve rootlets that extend down from the olfactory bulb to the olfactory mucosa of the upper parts of the nasal cavity. This nerve conducts odor information to the brainstem." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] synonym: "CN 1 development" RELATED [GOC:cls] synonym: "cranial nerve 1 development" EXACT [GOC:cls] synonym: "cranial nerve I development" EXACT [GOC:cls] is_a: GO:0021545 ! cranial nerve development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0001579 ! results in development of olfactory nerve relationship: RO:0002296 UBERON:0001579 ! results in development of olfactory nerve [Term] id: GO:0021554 name: optic nerve development namespace: biological_process def: "The process whose specific outcome is the progression of the optic nerve over time, from its formation to the mature structure. The sensory optic nerve originates from the bipolar cells of the retina and conducts visual information to the brainstem. The optic nerve exits the back of the eye in the orbit, enters the optic canal, and enters the central nervous system at the optic chiasm (crossing) where the nerve fibers become the optic tract just prior to entering the hindbrain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] synonym: "CN II development" RELATED [GOC:cls] synonym: "cranial nerve 2 development" EXACT [GOC:cls] synonym: "cranial nerve II development" EXACT [GOC:cls] is_a: GO:0021545 ! cranial nerve development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0000941 ! results in development of cranial nerve II relationship: RO:0002296 UBERON:0000941 ! results in development of cranial nerve II [Term] id: GO:0021555 name: midbrain-hindbrain boundary morphogenesis namespace: biological_process def: "The process in which the anatomical structure of the midbrain-hindbrain boundary is generated and organized. The midbrain-hindbrain domain of the embryonic brain is comprised of the mesencephalic vesicle and the first rhombencephalic vesicle at early somitogenesis stages. An organizing center at the boundary patterns the midbrain and hindbrain primordia of the neural plate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:15541513] synonym: "isthmus morphogenesis" EXACT [GOC:cls] synonym: "MHB morphogenesis" EXACT [GOC:cls] is_a: BFO:0000003 is_a: GO:0048598 ! embryonic morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0003052 ! results in morphogenesis of midbrain-hindbrain boundary relationship: BFO:0000050 GO:0030917 ! part of midbrain-hindbrain boundary development relationship: RO:0002298 UBERON:0003052 ! results in morphogenesis of midbrain-hindbrain boundary [Term] id: GO:0021556 name: central nervous system formation namespace: biological_process def: "The process that gives rise to the central nervous system. This process pertains to the initial formation of a structure from unspecified parts. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain, spinal cord and spinal nerves. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0582227089] is_a: BFO:0000003 is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0001017 ! results in formation of anatomical entity central nervous system relationship: BFO:0000050 GO:0021551 ! part of central nervous system morphogenesis relationship: RO:0002297 UBERON:0001017 ! results in formation of anatomical entity central nervous system [Term] id: GO:0021557 name: oculomotor nerve development namespace: biological_process def: "The process whose specific outcome is the progression of the oculomotor nerve over time, from its formation to the mature structure. This motor nerve innervates all extraocular muscles except the superior oblique and the lateral rectus muscles. The superior division supplies the levator palpebrae superioris and superior rectus muscles. The inferior division supplies the medial rectus, inferior rectus and inferior oblique muscles. This nerve also innervates the striated muscles of the eyelid. Pupillary constriction and lens movement are mediated by this nerve for near vision. In the orbit the inferior division sends branches that enter the ciliary ganglion where they form functional contacts (synapses) with the ganglion cells. The ganglion cells send nerve fibers into the back of the eye where they travel to ultimately innervate the ciliary muscle and the constrictor pupillae muscle." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] synonym: "CN III development" RELATED [GOC:cls] synonym: "cranial nerve 3 development" EXACT [GOC:cls] synonym: "cranial nerve III development" EXACT [GOC:cls] is_a: GO:0021545 ! cranial nerve development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0001643 ! results in development of oculomotor nerve relationship: BFO:0000050 GO:0021783 ! part of preganglionic parasympathetic fiber development relationship: RO:0002296 UBERON:0001643 ! results in development of oculomotor nerve [Term] id: GO:0021559 name: trigeminal nerve development namespace: biological_process def: "The process whose specific outcome is the progression of the trigeminal nerve over time, from its formation to the mature structure. The trigeminal nerve is composed of three large branches. They are the ophthalmic (V1, sensory), maxillary (V2, sensory) and mandibular (V3, motor and sensory) branches. The sensory ophthalmic branch travels through the superior orbital fissure and passes through the orbit to reach the skin of the forehead and top of the head. The maxillary nerve contains sensory branches that reach the pterygopalatine fossa via the inferior orbital fissure (face, cheek and upper teeth) and pterygopalatine canal (soft and hard palate, nasal cavity and pharynx). The motor part of the mandibular branch is distributed to the muscles of mastication, the mylohyoid muscle and the anterior belly of the digastric. The mandibular nerve also innervates the tensor veli palatini and tensor tympani muscles. The sensory part of the mandibular nerve is composed of branches that carry general sensory information from the mucous membranes of the mouth and cheek, anterior two-thirds of the tongue, lower teeth, skin of the lower jaw, side of the head and scalp and meninges of the anterior and middle cranial fossae." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] synonym: "CN V development" RELATED [GOC:cls] synonym: "cranial nerve 5 development" EXACT [GOC:cls] synonym: "cranial nerve V development" EXACT [GOC:cls] is_a: GO:0021545 ! cranial nerve development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0001645 ! results in development of trigeminal nerve relationship: RO:0002296 UBERON:0001645 ! results in development of trigeminal nerve [Term] id: GO:0021561 name: facial nerve development namespace: biological_process def: "The process whose specific outcome is the progression of the facial nerve over time, from its formation to the mature structure. This sensory and motor nerve supplies the muscles of facial expression and the expression and taste at the anterior two-thirds of the tongue. The principal branches are the superficial ophthalmic, buccal, palatine and hyomandibular. The main trunk synapses within pterygopalatine ganglion in the parotid gland and this ganglion then gives off nerve branches which supply the lacrimal gland and the mucous secreting glands of the nasal and oral cavities." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] synonym: "CN VII development" RELATED [GOC:cls] synonym: "cranial nerve 7 development" EXACT [GOC:cls] synonym: "cranial nerve VII development" EXACT [GOC:cls] is_a: GO:0021545 ! cranial nerve development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0001647 ! results in development of facial nerve relationship: BFO:0000050 GO:0021783 ! part of preganglionic parasympathetic fiber development relationship: RO:0002296 UBERON:0001647 ! results in development of facial nerve [Term] id: GO:0021562 name: vestibulocochlear nerve development namespace: biological_process def: "The process whose specific outcome is the progression of the vestibulocochlear nerve over time, from its formation to the mature structure. This sensory nerve innervates the membranous labyrinth of the inner ear. The vestibular branch innervates the vestibular apparatus that senses head position changes relative to gravity. The auditory branch innervates the cochlear duct, which is connected to the three bony ossicles which transduce sound waves into fluid movement in the cochlea." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] synonym: "acoustic nerve development" EXACT [PMID:11533729] synonym: "CN VIII development" EXACT [GOC:cls] synonym: "cranial nerve 8 development" EXACT [GOC:cls] synonym: "cranial nerve VIII development" EXACT [GOC:cls] is_a: GO:0021545 ! cranial nerve development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0001648 ! results in development of vestibulocochlear nerve relationship: RO:0002296 UBERON:0001648 ! results in development of vestibulocochlear nerve [Term] id: GO:0021563 name: glossopharyngeal nerve development namespace: biological_process def: "Various sensory and motor branches of the glossopharyngeal nerve supply nerve connections to the pharynx and back of the tongue. The branchial motor component contains motor fibers that innervate muscles that elevate the pharynx and larynx, and the tympanic branch supplies parasympathetic fibers to the otic ganglion." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] synonym: "CN IX development" RELATED [GOC:cls] synonym: "cranial nerve 9 development" EXACT [GOC:cls] synonym: "cranial nerve IX development" EXACT [GOC:cls] is_a: GO:0021545 ! cranial nerve development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0001649 ! results in development of glossopharyngeal nerve relationship: RO:0002296 UBERON:0001649 ! results in development of glossopharyngeal nerve [Term] id: GO:0021564 name: vagus nerve development namespace: biological_process def: "The process whose specific outcome is the progression of the vagus nerve over time, from its formation to the mature structure. This nerve is primarily sensory but also has visceromotor components. It originates in the brain stem and controls many autonomic functions of the heart, lungs, stomach, pharynx, larynx, trachea, esophagus and other gastrointestinal tract components. It controls some motor functions such as speech. The sensory branches mediate sensation from the pharynx, larynx, thorax and abdomen; it also innervates taste buds in the epiglottis." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] synonym: "CN X development" RELATED [GOC:cls] synonym: "cranial nerve 10 development" RELATED [GOC:cls] synonym: "cranial nerve X development" EXACT [GOC:cls] is_a: GO:0021545 ! cranial nerve development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0001759 ! results in development of vagus nerve relationship: BFO:0000050 GO:0021783 ! part of preganglionic parasympathetic fiber development relationship: RO:0002296 UBERON:0001759 ! results in development of vagus nerve [Term] id: GO:0021565 name: accessory nerve development namespace: biological_process def: "The process whose specific outcome is the progression of the accessory nerve over time, from its formation to the mature structure. In mice, the spinal branch of this motor nerve innervates the trapezius and the sternocleidomastoid muscles. The cranial branch joins the vagus nerve and innervates the same targets as the vagus nerve." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] synonym: "CN XI development" RELATED [GOC:cls] synonym: "cranial nerve 11 development" RELATED [GOC:cls] synonym: "cranial nerve XI development" EXACT [GOC:cls] synonym: "spinal accessory nerve development" EXACT [PMID:11533729] is_a: GO:0021545 ! cranial nerve development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0002019 ! results in development of accessory XI nerve relationship: RO:0002162 NCBITaxon:32523 ! in taxon Tetrapoda relationship: RO:0002296 UBERON:0002019 ! results in development of accessory XI nerve [Term] id: GO:0021566 name: hypoglossal nerve development namespace: biological_process def: "The process whose specific outcome is the progression of the hypoglossal nerve over time, from its formation to the mature structure. This motor nerve innervates all the intrinsic and all but one of the extrinsic muscles of the tongue." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] synonym: "CN XII development" RELATED [GOC:cls] synonym: "cranial nerve 12 development" RELATED [GOC:cls] synonym: "cranial nerve XII development" EXACT [GOC:cls] is_a: GO:0021545 ! cranial nerve development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0001650 ! results in development of hypoglossal nerve relationship: RO:0002162 NCBITaxon:32523 ! in taxon Tetrapoda relationship: RO:0002296 UBERON:0001650 ! results in development of hypoglossal nerve [Term] id: GO:0021567 name: rhombomere 1 development namespace: biological_process def: "The process whose specific outcome is the progression of rhombomere 1 over time, from its formation to the mature structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid] is_a: GO:0021546 ! rhombomere development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0005499 ! results in development of rhombomere 1 relationship: RO:0002296 UBERON:0005499 ! results in development of rhombomere 1 [Term] id: GO:0021575 name: hindbrain morphogenesis namespace: biological_process def: "The process in which the anatomical structure of the hindbrain is generated and organized. The hindbrain is the region consisting of the medulla, pons and cerebellum. Areas of the hindbrain control motor and autonomic functions." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] synonym: "rhombencephalon morphogenesis" RELATED [] is_a: BFO:0000003 is_a: GO:0009653 ! anatomical structure morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0002028 ! results in morphogenesis of hindbrain relationship: BFO:0000050 GO:0030902 ! part of hindbrain development relationship: RO:0002298 UBERON:0002028 ! results in morphogenesis of hindbrain [Term] id: GO:0021576 name: hindbrain formation namespace: biological_process def: "The process that gives rise to the hindbrain. This process pertains to the initial formation of a structure from unspecified parts. The hindbrain is the region consisting of the medulla, pons and cerebellum. Areas of the hindbrain control motor and autonomic functions." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] is_a: BFO:0000003 is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0002028 ! results in formation of anatomical entity hindbrain relationship: BFO:0000050 GO:0021575 ! part of hindbrain morphogenesis relationship: RO:0002297 UBERON:0002028 ! results in formation of anatomical entity hindbrain [Term] id: GO:0021578 name: hindbrain maturation namespace: biological_process def: "A developmental process, independent of morphogenetic (shape) change, that is required for the hindbrain to attain its fully functional state. The hindbrain is the region consisting of the medulla, pons and cerebellum. Areas of the hindbrain control motor and autonomic functions." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] is_a: GO:0071695 ! anatomical structure maturation intersection_of: GO:0021700 ! developmental maturation intersection_of: RO:0002299 UBERON:0002028 ! results in maturation of hindbrain relationship: BFO:0000050 GO:0021626 ! part of central nervous system maturation relationship: BFO:0000050 GO:0030902 ! part of hindbrain development relationship: RO:0002299 UBERON:0002028 ! results in maturation of hindbrain [Term] id: GO:0021579 name: medulla oblongata morphogenesis namespace: biological_process def: "The process in which the anatomical structure of the medulla oblongata is generated and organized. The medulla oblongata lies directly above the spinal cord and controls vital autonomic functions such as digestion, breathing and the control of heart rate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] synonym: "medulla morphogenesis" RELATED [] synonym: "myelencephalon morphogenesis" RELATED [] is_a: BFO:0000003 is_a: GO:0009653 ! anatomical structure morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0001896 ! results in morphogenesis of medulla oblongata relationship: BFO:0000050 GO:0021550 ! part of medulla oblongata development relationship: BFO:0000050 GO:0021575 ! part of hindbrain morphogenesis relationship: RO:0002298 UBERON:0001896 ! results in morphogenesis of medulla oblongata [Term] id: GO:0021580 name: medulla oblongata formation namespace: biological_process def: "The process that gives rise to the medulla oblongata. This process pertains to the initial formation of a structure from unspecified parts. The medulla oblongata lies directly above the spinal cord and controls vital autonomic functions such as digestion, breathing and the control of heart rate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] synonym: "medulla biosynthesis" RELATED [] synonym: "medulla formation" RELATED [] synonym: "myelencephalon biosynthesis" RELATED [] synonym: "myelencephalon formation" RELATED [] is_a: BFO:0000003 is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0001896 ! results in formation of anatomical entity medulla oblongata relationship: BFO:0000050 GO:0021576 ! part of hindbrain formation relationship: BFO:0000050 GO:0021579 ! part of medulla oblongata morphogenesis relationship: RO:0002297 UBERON:0001896 ! results in formation of anatomical entity medulla oblongata [Term] id: GO:0021582 name: medulla oblongata maturation namespace: biological_process def: "A developmental process, independent of morphogenetic (shape) change, that is required for the medulla oblongata to attain its fully functional state. The medulla oblongata lies directly above the spinal cord and controls vital autonomic functions such as digestion, breathing and the control of heart rate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] synonym: "medulla maturation" RELATED [] synonym: "myelencephalon maturation" RELATED [] is_a: GO:0071695 ! anatomical structure maturation intersection_of: GO:0021700 ! developmental maturation intersection_of: RO:0002299 UBERON:0001896 ! results in maturation of medulla oblongata relationship: BFO:0000050 GO:0021550 ! part of medulla oblongata development relationship: BFO:0000050 GO:0021578 ! part of hindbrain maturation relationship: RO:0002299 UBERON:0001896 ! results in maturation of medulla oblongata [Term] id: GO:0021583 name: pons morphogenesis namespace: biological_process def: "The process in which the anatomical structure of the pons is generated and organized. The pons lies above the medulla and next to the cerebellum. The pons conveys information about movement from the cerebral hemisphere to the cerebellum." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] is_a: BFO:0000003 is_a: GO:0009653 ! anatomical structure morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0000988 ! results in morphogenesis of pons relationship: BFO:0000050 GO:0021548 ! part of pons development relationship: BFO:0000050 GO:0021575 ! part of hindbrain morphogenesis relationship: RO:0002298 UBERON:0000988 ! results in morphogenesis of pons [Term] id: GO:0021584 name: pons formation namespace: biological_process def: "The process that gives rise to the pons. This process pertains to the initial formation of a structure from unspecified parts. The pons lies above the medulla and next to the cerebellum. The pons conveys information about movement from the cerebral hemisphere to the cerebellum." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] is_a: BFO:0000003 is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0000988 ! results in formation of anatomical entity pons relationship: BFO:0000050 GO:0021576 ! part of hindbrain formation relationship: BFO:0000050 GO:0021583 ! part of pons morphogenesis relationship: RO:0002297 UBERON:0000988 ! results in formation of anatomical entity pons [Term] id: GO:0021586 name: pons maturation namespace: biological_process def: "A developmental process, independent of morphogenetic (shape) change, that is required for the pons to attain its fully functional state. The pons lies above the medulla and next to the cerebellum. The pons conveys information about movement from the cerebral hemisphere to the cerebellum." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] is_a: GO:0071695 ! anatomical structure maturation intersection_of: GO:0021700 ! developmental maturation intersection_of: RO:0002299 UBERON:0000988 ! results in maturation of pons relationship: BFO:0000050 GO:0021548 ! part of pons development relationship: BFO:0000050 GO:0021578 ! part of hindbrain maturation relationship: RO:0002299 UBERON:0000988 ! results in maturation of pons [Term] id: GO:0021587 name: cerebellum morphogenesis namespace: biological_process def: "The process in which the anatomical structure of the cerebellum is generated and organized. The cerebellum is the portion of the brain in the back of the head between the cerebrum and the pons. The cerebellum controls balance for walking and standing, modulates the force and range of movement and is involved in the learning of motor skills." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] is_a: BFO:0000003 is_a: GO:0009653 ! anatomical structure morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0002037 ! results in morphogenesis of cerebellum relationship: BFO:0000050 GO:0021549 ! part of cerebellum development relationship: BFO:0000050 GO:0021575 ! part of hindbrain morphogenesis relationship: RO:0002298 UBERON:0002037 ! results in morphogenesis of cerebellum [Term] id: GO:0021588 name: cerebellum formation namespace: biological_process def: "The process that gives rise to the cerebellum. This process pertains to the initial formation of a structure from unspecified parts. The cerebellum is the portion of the brain in the back of the head between the cerebrum and the pons. The cerebellum controls balance for walking and standing, modulates the force and range of movement and is involved in the learning of motor skills." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] is_a: BFO:0000003 is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0002037 ! results in formation of anatomical entity cerebellum relationship: BFO:0000050 GO:0021576 ! part of hindbrain formation relationship: BFO:0000050 GO:0021587 ! part of cerebellum morphogenesis relationship: RO:0002297 UBERON:0002037 ! results in formation of anatomical entity cerebellum [Term] id: GO:0021590 name: cerebellum maturation namespace: biological_process def: "A developmental process, independent of morphogenetic (shape) change, that is required for the cerebellum to attain its fully functional state. The cerebellum is the portion of the brain in the back of the head between the cerebrum and the pons. The cerebellum controls balance for walking and standing, modulates the force and range of movement and is involved in the learning of motor skills." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] is_a: GO:0071695 ! anatomical structure maturation intersection_of: GO:0021700 ! developmental maturation intersection_of: RO:0002299 UBERON:0002037 ! results in maturation of cerebellum relationship: BFO:0000050 GO:0021549 ! part of cerebellum development relationship: BFO:0000050 GO:0021578 ! part of hindbrain maturation relationship: RO:0002299 UBERON:0002037 ! results in maturation of cerebellum [Term] id: GO:0021591 name: ventricular system development namespace: biological_process def: "The process whose specific outcome is the progression of the brain ventricular system over time, from its formation to the mature structure. The brain ventricular system consists of four communicating cavities within the brain that are continuous with the central canal of the spinal cord. These cavities include two lateral ventricles, the third ventricle and the fourth ventricle. Cerebrospinal fluid fills the ventricles and is produced by the choroid plexus." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] is_a: GO:0048731 ! system development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0005281 ! results in development of ventricular system of central nervous system relationship: BFO:0000050 GO:0007420 ! part of brain development relationship: RO:0002296 UBERON:0005281 ! results in development of ventricular system of central nervous system [Term] id: GO:0021592 name: fourth ventricle development namespace: biological_process def: "The process whose specific outcome is the progression of the fourth ventricle over time, from its formation to the mature structure. The fourth ventricle is an irregularly shaped cavity in the rhombencephalon, between the medulla oblongata, the pons, and the isthmus in front, and the cerebellum behind. It is continuous with the central canal of the cord below and with the cerebral aqueduct above, and through its lateral and median apertures it communicates with the subarachnoid space." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] is_a: GO:0048856 ! anatomical structure development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0002422 ! results in development of fourth ventricle relationship: BFO:0000050 GO:0021591 ! part of ventricular system development relationship: BFO:0000050 GO:0030902 ! part of hindbrain development relationship: RO:0002296 UBERON:0002422 ! results in development of fourth ventricle [Term] id: GO:0021593 name: rhombomere morphogenesis namespace: biological_process def: "The process in which the anatomical structure of the rhombomere is generated and organized. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] is_a: BFO:0000003 is_a: GO:0009653 ! anatomical structure morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0001892 ! results in morphogenesis of rhombomere relationship: BFO:0000050 GO:0021546 ! part of rhombomere development relationship: RO:0002298 UBERON:0001892 ! results in morphogenesis of rhombomere [Term] id: GO:0021594 name: rhombomere formation namespace: biological_process def: "The process that gives rise to the rhombomere. This process pertains to the initial formation of a structure from unspecified parts. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] is_a: BFO:0000003 is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0001892 ! results in formation of anatomical entity rhombomere relationship: BFO:0000050 GO:0021593 ! part of rhombomere morphogenesis relationship: RO:0002297 UBERON:0001892 ! results in formation of anatomical entity rhombomere [Term] id: GO:0021602 name: cranial nerve morphogenesis namespace: biological_process def: "The process in which the anatomical structure of the cranial nerves are generated and organized. The cranial nerves are composed of twelve pairs of nerves that emanate from the nervous tissue of the hindbrain. These nerves are sensory, motor, or mixed in nature, and provide the motor and general sensory innervation of the head, neck and viscera. They mediate vision, hearing, olfaction and taste and carry the parasympathetic innervation of the autonomic ganglia that control visceral functions." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] is_a: BFO:0000003 is_a: GO:0009653 ! anatomical structure morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0001785 ! results in morphogenesis of cranial nerve relationship: BFO:0000050 GO:0021545 ! part of cranial nerve development relationship: RO:0002298 UBERON:0001785 ! results in morphogenesis of cranial nerve [Term] id: GO:0021603 name: cranial nerve formation namespace: biological_process def: "The process that gives rise to the cranial nerves. This process pertains to the initial formation of a structure from unspecified parts. The cranial nerves are composed of twelve pairs of nerves that emanate from the nervous tissue of the hindbrain. These nerves are sensory, motor, or mixed in nature, and provide the motor and general sensory innervation of the head, neck and viscera. They mediate vision, hearing, olfaction and taste and carry the parasympathetic innervation of the autonomic ganglia that control visceral functions." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] is_a: BFO:0000003 is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0001785 ! results in formation of anatomical entity cranial nerve relationship: BFO:0000050 GO:0021602 ! part of cranial nerve morphogenesis relationship: RO:0002297 UBERON:0001785 ! results in formation of anatomical entity cranial nerve [Term] id: GO:0021605 name: cranial nerve maturation namespace: biological_process def: "A developmental process, independent of morphogenetic (shape) change, that is required for a cranial nerve to attain its fully functional state. The cranial nerves are composed of twelve pairs of nerves that emanate from the nervous tissue of the hindbrain. These nerves are sensory, motor, or mixed in nature, and provide the motor and general sensory innervation of the head, neck and viscera. They mediate vision, hearing, olfaction and taste and carry the parasympathetic innervation of the autonomic ganglia that control visceral functions." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] is_a: GO:0021682 ! nerve maturation intersection_of: GO:0021700 ! developmental maturation intersection_of: RO:0002299 UBERON:0001785 ! results in maturation of cranial nerve relationship: BFO:0000050 GO:0021545 ! part of cranial nerve development relationship: RO:0002299 UBERON:0001785 ! results in maturation of cranial nerve [Term] id: GO:0021606 name: accessory nerve maturation namespace: biological_process def: "A developmental process, independent of morphogenetic (shape) change, that is required for the accessory nerve to attain its fully functional state. The spinal branch of this motor nerve innervates the trapezius and the sternocleidomastoid muscles. The cranial branch joins the vagus nerve and innervates the same targets as the vagus nerve." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] synonym: "CN XI maturation" RELATED [] synonym: "spinal accessory nerve maturation" RELATED [] is_a: GO:0021605 ! cranial nerve maturation intersection_of: GO:0021700 ! developmental maturation intersection_of: RO:0002299 UBERON:0002019 ! results in maturation of accessory XI nerve relationship: BFO:0000050 GO:0021565 ! part of accessory nerve development relationship: RO:0002299 UBERON:0002019 ! results in maturation of accessory XI nerve [Term] id: GO:0021607 name: accessory nerve morphogenesis namespace: biological_process def: "The process in which the anatomical structure of the accessory nerve is generated and organized. The spinal branch of this motor nerve innervates the trapezius and the sternocleidomastoid muscles. The cranial branch joins the vagus nerve and innervates the same targets as the vagus nerve." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] synonym: "CN XI morphogenesis" RELATED [] is_a: GO:0021602 ! cranial nerve morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0002019 ! results in morphogenesis of accessory XI nerve relationship: BFO:0000050 GO:0021565 ! part of accessory nerve development relationship: RO:0002298 UBERON:0002019 ! results in morphogenesis of accessory XI nerve [Term] id: GO:0021608 name: accessory nerve formation namespace: biological_process def: "The process that gives rise to the accessory nerve. This process pertains to the initial formation of a structure from unspecified parts. The spinal branch of this motor nerve innervates the trapezius and the sternocleidomastoid muscles. The cranial branch joins the vagus nerve and innervates the same targets as the vagus nerve." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] synonym: "CN XI biosynthesis" RELATED [] synonym: "CN XI formation" RELATED [] is_a: GO:0021603 ! cranial nerve formation intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0002019 ! results in formation of anatomical entity accessory XI nerve relationship: BFO:0000050 GO:0021607 ! part of accessory nerve morphogenesis relationship: RO:0002297 UBERON:0002019 ! results in formation of anatomical entity accessory XI nerve [Term] id: GO:0021610 name: facial nerve morphogenesis namespace: biological_process def: "The process in which the anatomical structure of the facial nerve is generated and organized. This sensory and motor nerve supplies the muscles of facial expression and the expression and taste at the anterior two-thirds of the tongue. The principal branches are the superficial ophthalmic, buccal, palatine and hyomandibular. The main trunk synapses within pterygopalatine ganglion in the parotid gland and this ganglion then gives of nerve branches which supply the lacrimal gland and the mucous secreting glands of the nasal and oral cavities." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] synonym: "CN VII morphogenesis" RELATED [] is_a: GO:0021602 ! cranial nerve morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0001647 ! results in morphogenesis of facial nerve relationship: BFO:0000050 GO:0021561 ! part of facial nerve development relationship: RO:0002298 UBERON:0001647 ! results in morphogenesis of facial nerve [Term] id: GO:0021611 name: facial nerve formation namespace: biological_process def: "The process that gives rise to the facial nerve. This process pertains to the initial formation of a structure from unspecified parts. This sensory and motor nerve supplies the muscles of facial expression and the expression and taste at the anterior two-thirds of the tongue. The principal branches are the superficial ophthalmic, buccal, palatine and hyomandibular. The main trunk synapses within pterygopalatine ganglion in the parotid gland and this ganglion then gives of nerve branches which supply the lacrimal gland and the mucous secreting glands of the nasal and oral cavities." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] synonym: "CN VII biosynthesis" RELATED [] synonym: "CN VII formation" RELATED [] is_a: GO:0021603 ! cranial nerve formation intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0001647 ! results in formation of anatomical entity facial nerve relationship: BFO:0000050 GO:0021610 ! part of facial nerve morphogenesis relationship: RO:0002297 UBERON:0001647 ! results in formation of anatomical entity facial nerve [Term] id: GO:0021613 name: facial nerve maturation namespace: biological_process def: "A developmental process, independent of morphogenetic (shape) change, that is required for the facial nerve to attain its fully functional state. This sensory and motor nerve supplies the muscles of facial expression and the expression and taste at the anterior two-thirds of the tongue. The principal branches are the superficial ophthalmic, buccal, palatine and hyomandibular. The main trunk synapses within pterygopalatine ganglion in the parotid gland and this ganglion then gives of nerve branches which supply the lacrimal gland and the mucous secreting glands of the nasal and oral cavities." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] synonym: "CN VII maturation" RELATED [] is_a: GO:0021605 ! cranial nerve maturation intersection_of: GO:0021700 ! developmental maturation intersection_of: RO:0002299 UBERON:0001647 ! results in maturation of facial nerve relationship: BFO:0000050 GO:0021561 ! part of facial nerve development relationship: RO:0002299 UBERON:0001647 ! results in maturation of facial nerve [Term] id: GO:0021614 name: glossopharyngeal nerve maturation namespace: biological_process def: "A developmental process, independent of morphogenetic (shape) change, that is required for the glossopharyngeal nerve to attain its fully functional state. Various sensory and motor branches of the glossopharyngeal nerve supply nerve connections to the pharynx and back of the tongue. The branchial motor component contains motor fibers that innervate muscles that elevate the pharynx and larynx, and the tympanic branch supplies parasympathetic fibers to the otic ganglion." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] synonym: "CN IX maturation" RELATED [] is_a: GO:0021605 ! cranial nerve maturation intersection_of: GO:0021700 ! developmental maturation intersection_of: RO:0002299 UBERON:0001649 ! results in maturation of glossopharyngeal nerve relationship: BFO:0000050 GO:0021563 ! part of glossopharyngeal nerve development relationship: RO:0002299 UBERON:0001649 ! results in maturation of glossopharyngeal nerve [Term] id: GO:0021615 name: glossopharyngeal nerve morphogenesis namespace: biological_process def: "The process in which the anatomical structure of the glossopharyngeal nerve is generated and organized. Various sensory and motor branches of the glossopharyngeal nerve supply nerve connections to the pharynx and back of the tongue. The branchial motor component contains motor fibers that innervate muscles that elevate the pharynx and larynx, and the tympanic branch supplies parasympathetic fibers to the otic ganglion." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] synonym: "CN IX morphogenesis" RELATED [] is_a: GO:0021602 ! cranial nerve morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0001649 ! results in morphogenesis of glossopharyngeal nerve relationship: BFO:0000050 GO:0021563 ! part of glossopharyngeal nerve development relationship: RO:0002298 UBERON:0001649 ! results in morphogenesis of glossopharyngeal nerve [Term] id: GO:0021616 name: glossopharyngeal nerve formation namespace: biological_process def: "The process that gives rise to the glossopharyngeal nerve. This process pertains to the initial formation of a structure from unspecified parts. Various sensory and motor branches of the glossopharyngeal nerve supply nerve connections to the pharynx and back of the tongue. The branchial motor component contains motor fibers that innervate muscles that elevate the pharynx and larynx, and the tympanic branch supplies parasympathetic fibers to the otic ganglion." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] synonym: "CN IX biosynthesis" RELATED [] synonym: "CN IX formation" RELATED [] is_a: GO:0021603 ! cranial nerve formation intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0001649 ! results in formation of anatomical entity glossopharyngeal nerve relationship: BFO:0000050 GO:0021615 ! part of glossopharyngeal nerve morphogenesis relationship: RO:0002297 UBERON:0001649 ! results in formation of anatomical entity glossopharyngeal nerve [Term] id: GO:0021618 name: hypoglossal nerve morphogenesis namespace: biological_process def: "The process in which the anatomical structure of the hypoglossal nerve is generated and organized. This motor nerve innervates all the intrinsic and all but one of the extrinsic muscles of the tongue." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] synonym: "CN XII morphogenesis" RELATED [] is_a: GO:0021602 ! cranial nerve morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0001650 ! results in morphogenesis of hypoglossal nerve relationship: BFO:0000050 GO:0021566 ! part of hypoglossal nerve development relationship: RO:0002298 UBERON:0001650 ! results in morphogenesis of hypoglossal nerve [Term] id: GO:0021619 name: hypoglossal nerve maturation namespace: biological_process def: "A developmental process, independent of morphogenetic (shape) change, that is required for the hypoglossal nerve to attain its fully functional state. This motor nerve innervates all the intrinsic and all but one of the extrinsic muscles of the tongue." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] synonym: "CN XII maturation" RELATED [] is_a: GO:0021605 ! cranial nerve maturation intersection_of: GO:0021700 ! developmental maturation intersection_of: RO:0002299 UBERON:0001650 ! results in maturation of hypoglossal nerve relationship: BFO:0000050 GO:0021566 ! part of hypoglossal nerve development relationship: RO:0002299 UBERON:0001650 ! results in maturation of hypoglossal nerve [Term] id: GO:0021620 name: hypoglossal nerve formation namespace: biological_process def: "The process that gives rise to the hypoglossal nerve. This process pertains to the initial formation of a structure from unspecified parts. This motor nerve innervates all the intrinsic and all but one of the extrinsic muscles of the tongue." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] synonym: "CN XII biosynthesis" RELATED [] synonym: "CN XII formation" RELATED [] is_a: GO:0021603 ! cranial nerve formation intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0001650 ! results in formation of anatomical entity hypoglossal nerve relationship: BFO:0000050 GO:0021618 ! part of hypoglossal nerve morphogenesis relationship: RO:0002297 UBERON:0001650 ! results in formation of anatomical entity hypoglossal nerve [Term] id: GO:0021622 name: oculomotor nerve morphogenesis namespace: biological_process def: "The process in which the anatomical structure of the oculomotor nerve is generated and organized. This motor nerve innervates all extraocular muscles except the superior oblique and the lateral rectus muscles. The superior division supplies the levator palpebrae superioris and superior rectus muscles. The inferior division supplies the medial rectus, inferior rectus and inferior oblique muscles. This nerve also innervates the striated muscles of the eyelid. Pupillary constriction and lens movement are mediated by this nerve for near vision. In the orbit the inferior division sends branches that enter the ciliary ganglion where they form functional contacts (synapses) with the ganglion cells. The ganglion cells send nerve fibers into the back of the eye where they travel to ultimately innervate the ciliary muscle and the constrictor pupillae muscle." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] synonym: "CN III morphogenesis" RELATED [] is_a: GO:0021602 ! cranial nerve morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0001643 ! results in morphogenesis of oculomotor nerve relationship: BFO:0000050 GO:0021557 ! part of oculomotor nerve development relationship: RO:0002298 UBERON:0001643 ! results in morphogenesis of oculomotor nerve [Term] id: GO:0021623 name: oculomotor nerve formation namespace: biological_process def: "The process that gives rise to the oculomotor nerve. This process pertains to the initial formation of a structure from unspecified parts. This motor nerve innervates all extraocular muscles except the superior oblique and the lateral rectus muscles. The superior division supplies the levator palpebrae superioris and superior rectus muscles. The inferior division supplies the medial rectus, inferior rectus and inferior oblique muscles. This nerve also innervates the striated muscles of the eyelid. Pupillary constriction and lens movement are mediated by this nerve for near vision. In the orbit the inferior division sends branches that enter the ciliary ganglion where they form functional contacts (synapses) with the ganglion cells. The ganglion cells send nerve fibers into the back of the eye where they travel to ultimately innervate the ciliary muscle and the constrictor pupillae muscle." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] synonym: "CN III biosynthesis" RELATED [] synonym: "CN III formation" RELATED [] is_a: GO:0021603 ! cranial nerve formation intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0001643 ! results in formation of anatomical entity oculomotor nerve relationship: BFO:0000050 GO:0021622 ! part of oculomotor nerve morphogenesis relationship: RO:0002297 UBERON:0001643 ! results in formation of anatomical entity oculomotor nerve [Term] id: GO:0021625 name: oculomotor nerve maturation namespace: biological_process def: "A developmental process, independent of morphogenetic (shape) change, that is required for the oculomotor nerve to attain its fully functional state. This motor nerve innervates all extraocular muscles except the superior oblique and the lateral rectus muscles. The superior division supplies the levator palpebrae superioris and superior rectus muscles. The inferior division supplies the medial rectus, inferior rectus and inferior oblique muscles. This nerve also innervates the striated muscles of the eyelid. Pupillary constriction and lens movement are mediated by this nerve for near vision. In the orbit the inferior division sends branches that enter the ciliary ganglion where they form functional contacts (synapses) with the ganglion cells. The ganglion cells send nerve fibers into the back of the eye where they travel to ultimately innervate the ciliary muscle and the constrictor pupillae muscle." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] synonym: "CN III maturation" RELATED [] is_a: GO:0021605 ! cranial nerve maturation intersection_of: GO:0021700 ! developmental maturation intersection_of: RO:0002299 UBERON:0001643 ! results in maturation of oculomotor nerve relationship: BFO:0000050 GO:0021557 ! part of oculomotor nerve development relationship: RO:0002299 UBERON:0001643 ! results in maturation of oculomotor nerve [Term] id: GO:0021626 name: central nervous system maturation namespace: biological_process def: "A developmental process, independent of morphogenetic (shape) change, that is required for the central nervous system to attain its fully functional state. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain and spinal cord. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0582227089] is_a: GO:0071695 ! anatomical structure maturation intersection_of: GO:0021700 ! developmental maturation intersection_of: RO:0002299 UBERON:0001017 ! results in maturation of central nervous system relationship: BFO:0000050 GO:0007417 ! part of central nervous system development relationship: RO:0002299 UBERON:0001017 ! results in maturation of central nervous system [Term] id: GO:0021627 name: olfactory nerve morphogenesis namespace: biological_process def: "The process in which the anatomical structure of the olfactory nerve is generated and organized. The olfactory nerve is a collection of sensory nerve rootlets that extend down from the olfactory bulb to the olfactory mucosa of the upper parts of the nasal cavity. This nerve conducts odor information to the brainstem." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] synonym: "CN I morphogenesis" RELATED [] is_a: GO:0021602 ! cranial nerve morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0001579 ! results in morphogenesis of olfactory nerve relationship: BFO:0000050 GO:0021553 ! part of olfactory nerve development relationship: RO:0002298 UBERON:0001579 ! results in morphogenesis of olfactory nerve [Term] id: GO:0021628 name: olfactory nerve formation namespace: biological_process def: "The process that gives rise to the olfactory nerve. This process pertains to the initial formation of a structure from unspecified parts. The olfactory nerve is a collection of sensory nerve rootlets that extend down from the olfactory bulb to the olfactory mucosa of the upper parts of the nasal cavity. This nerve conducts odor information to the brainstem." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] synonym: "CN I biosynthesis" RELATED [] synonym: "CN I formation" RELATED [] is_a: GO:0021603 ! cranial nerve formation intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0001579 ! results in formation of anatomical entity olfactory nerve relationship: BFO:0000050 GO:0021627 ! part of olfactory nerve morphogenesis relationship: RO:0002297 UBERON:0001579 ! results in formation of anatomical entity olfactory nerve [Term] id: GO:0021630 name: olfactory nerve maturation namespace: biological_process def: "A developmental process, independent of morphogenetic (shape) change, that is required for the olfactory nerve to attain its fully functional state. The olfactory nerve is a collection of sensory nerve rootlets that extend down from the olfactory bulb to the olfactory mucosa of the upper parts of the nasal cavity. This nerve conducts odor information to the brainstem." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid] synonym: "CN I maturation" EXACT [] is_a: GO:0021605 ! cranial nerve maturation intersection_of: GO:0021700 ! developmental maturation intersection_of: RO:0002299 UBERON:0001579 ! results in maturation of olfactory nerve relationship: BFO:0000050 GO:0021553 ! part of olfactory nerve development relationship: RO:0002299 UBERON:0001579 ! results in maturation of olfactory nerve [Term] id: GO:0021631 name: optic nerve morphogenesis namespace: biological_process def: "The process in which the anatomical structure of the optic nerve is generated and organized. The sensory optic nerve originates from the bipolar cells of the retina and conducts visual information to the brainstem. The optic nerve exits the back of the eye in the orbit, enters the optic canal, and enters the central nervous system at the optic chiasm (crossing) where the nerve fibers become the optic tract just prior to entering the hindbrain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] synonym: "CN II morphogenesis" RELATED [] is_a: GO:0021602 ! cranial nerve morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0000941 ! results in morphogenesis of cranial nerve II relationship: BFO:0000050 GO:0021554 ! part of optic nerve development relationship: RO:0002298 UBERON:0000941 ! results in morphogenesis of cranial nerve II [Term] id: GO:0021632 name: optic nerve maturation namespace: biological_process def: "A developmental process, independent of morphogenetic (shape) change, that is required for the optic nerve to attain its fully functional state. The sensory optic nerve originates from the bipolar cells of the retina and conducts visual information to the brainstem. The optic nerve exits the back of the eye in the orbit, enters the optic canal, and enters the central nervous system at the optic chiasm (crossing) where the nerve fibers become the optic tract just prior to entering the hindbrain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] synonym: "CN II maturation" EXACT [] is_a: GO:0021605 ! cranial nerve maturation intersection_of: GO:0021700 ! developmental maturation intersection_of: RO:0002299 UBERON:0000941 ! results in maturation of cranial nerve II relationship: BFO:0000050 GO:0021554 ! part of optic nerve development relationship: RO:0002299 UBERON:0000941 ! results in maturation of cranial nerve II [Term] id: GO:0021634 name: optic nerve formation namespace: biological_process def: "The process that gives rise to the optic nerve. This process pertains to the initial formation of a structure from unspecified parts. The sensory optic nerve originates from the bipolar cells of the retina and conducts visual information to the brainstem. The optic nerve exits the back of the eye in the orbit, enters the optic canal, and enters the central nervous system at the optic chiasm (crossing) where the nerve fibers become the optic tract just prior to entering the hindbrain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] synonym: "CN II biosynthesis" RELATED [] synonym: "CN II formation" RELATED [] is_a: GO:0021603 ! cranial nerve formation intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0000941 ! results in formation of anatomical entity cranial nerve II relationship: BFO:0000050 GO:0021631 ! part of optic nerve morphogenesis relationship: RO:0002297 UBERON:0000941 ! results in formation of anatomical entity cranial nerve II [Term] id: GO:0021635 name: trigeminal nerve maturation namespace: biological_process def: "A developmental process, independent of morphogenetic (shape) change, that is required for the trigeminal nerve to attain its fully functional state. The trigeminal nerve is composed of three large branches. They are the ophthalmic (V1, sensory), maxillary (V2, sensory) and mandibular (V3, motor and sensory) branches. The sensory ophthalmic branch travels through the superior orbital fissure and passes through the orbit to reach the skin of the forehead and top of the head. The maxillary nerve contains sensory branches that reach the pterygopalatine fossa via the inferior orbital fissure (face, cheek and upper teeth) and pterygopalatine canal (soft and hard palate, nasal cavity and pharynx). The motor part of the mandibular branch is distributed to the muscles of mastication, the mylohyoid muscle and the anterior belly of the digastric. The mandibular nerve also innervates the tensor veli palatini and tensor tympani muscles. The sensory part of the mandibular nerve is composed of branches that carry general sensory information from the mucous membranes of the mouth and cheek, anterior two-thirds of the tongue, lower teeth, skin of the lower jaw, side of the head and scalp and meninges of the anterior and middle cranial fossae." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] synonym: "CN V maturation" RELATED [] is_a: GO:0021605 ! cranial nerve maturation intersection_of: GO:0021700 ! developmental maturation intersection_of: RO:0002299 UBERON:0001645 ! results in maturation of trigeminal nerve relationship: BFO:0000050 GO:0021559 ! part of trigeminal nerve development relationship: RO:0002299 UBERON:0001645 ! results in maturation of trigeminal nerve [Term] id: GO:0021636 name: trigeminal nerve morphogenesis namespace: biological_process def: "The process in which the anatomical structure of the trigeminal nerve is generated and organized. The trigeminal nerve is composed of three large branches. They are the ophthalmic (V1, sensory), maxillary (V2, sensory) and mandibular (V3, motor and sensory) branches. The sensory ophthalmic branch travels through the superior orbital fissure and passes through the orbit to reach the skin of the forehead and top of the head. The maxillary nerve contains sensory branches that reach the pterygopalatine fossa via the inferior orbital fissure (face, cheek and upper teeth) and pterygopalatine canal (soft and hard palate, nasal cavity and pharynx). The motor part of the mandibular branch is distributed to the muscles of mastication, the mylohyoid muscle and the anterior belly of the digastric. The mandibular nerve also innervates the tensor veli palatini and tensor tympani muscles. The sensory part of the mandibular nerve is composed of branches that carry general sensory information from the mucous membranes of the mouth and cheek, anterior two-thirds of the tongue, lower teeth, skin of the lower jaw, side of the head and scalp and meninges of the anterior and middle cranial fossae." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] synonym: "CN V morphogenesis" RELATED [] is_a: GO:0021602 ! cranial nerve morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0001645 ! results in morphogenesis of trigeminal nerve relationship: BFO:0000050 GO:0021559 ! part of trigeminal nerve development relationship: RO:0002298 UBERON:0001645 ! results in morphogenesis of trigeminal nerve [Term] id: GO:0021638 name: trigeminal nerve formation namespace: biological_process def: "The process that gives rise to the trigeminal nerve. This process pertains to the initial formation of a structure from unspecified parts. The trigeminal nerve is composed of three large branches. They are the ophthalmic (V1, sensory), maxillary (V2, sensory) and mandibular (V3, motor and sensory) branches. The sensory ophthalmic branch travels through the superior orbital fissure and passes through the orbit to reach the skin of the forehead and top of the head. The maxillary nerve contains sensory branches that reach the pterygopalatine fossa via the inferior orbital fissure (face, cheek and upper teeth) and pterygopalatine canal (soft and hard palate, nasal cavity and pharynx). The motor part of the mandibular branch is distributed to the muscles of mastication, the mylohyoid muscle and the anterior belly of the digastric. The mandibular nerve also innervates the tensor veli palatini and tensor tympani muscles. The sensory part of the mandibular nerve is composed of branches that carry general sensory information from the mucous membranes of the mouth and cheek, anterior two-thirds of the tongue, lower teeth, skin of the lower jaw, side of the head and scalp and meninges of the anterior and middle cranial fossae." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] synonym: "CN V biosynthesis" RELATED [] synonym: "CN V formation" RELATED [] is_a: GO:0021603 ! cranial nerve formation intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0001645 ! results in formation of anatomical entity trigeminal nerve relationship: BFO:0000050 GO:0021636 ! part of trigeminal nerve morphogenesis relationship: RO:0002297 UBERON:0001645 ! results in formation of anatomical entity trigeminal nerve [Term] id: GO:0021643 name: vagus nerve maturation namespace: biological_process def: "A developmental process, independent of morphogenetic (shape) change, that is required for the vagus nerve to attain its fully functional state. This nerve is primarily sensory but also has visceromotor components. It originates in the brain stem and controls many autonomic functions of the heart, lungs, stomach, pharynx, larynx, trachea, esophagus and other gastrointestinal tract components. It controls some motor functions such as speech. The sensory branches mediate sensation from the pharynx, larynx, thorax and abdomen; it also innervates taste buds in the epiglottis." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] synonym: "CN X maturation" RELATED [] is_a: GO:0021605 ! cranial nerve maturation intersection_of: GO:0021700 ! developmental maturation intersection_of: RO:0002299 UBERON:0001759 ! results in maturation of vagus nerve relationship: BFO:0000050 GO:0021564 ! part of vagus nerve development relationship: RO:0002299 UBERON:0001759 ! results in maturation of vagus nerve [Term] id: GO:0021644 name: vagus nerve morphogenesis namespace: biological_process def: "The process in which the anatomical structure of the vagus nerve is generated and organized. This nerve is primarily sensory but also has visceromotor components. It originates in the brain stem and controls many autonomic functions of the heart, lungs, stomach, pharynx, larynx, trachea, esophagus and other gastrointestinal tract components. It controls some motor functions such as speech. The sensory branches mediate sensation from the pharynx, larynx, thorax and abdomen; it also innervates taste buds in the epiglottis." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] synonym: "CN X morphogenesis" RELATED [] is_a: GO:0021602 ! cranial nerve morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0001759 ! results in morphogenesis of vagus nerve relationship: BFO:0000050 GO:0021564 ! part of vagus nerve development relationship: RO:0002298 UBERON:0001759 ! results in morphogenesis of vagus nerve [Term] id: GO:0021646 name: vagus nerve formation namespace: biological_process def: "The process that gives rise to the vagus nerve. This process pertains to the initial formation of a structure from unspecified parts. This nerve is primarily sensory but also has visceromotor components. It originates in the brain stem and controls many autonomic functions of the heart, lungs, stomach, pharynx, larynx, trachea, esophagus and other gastrointestinal tract components. It controls some motor functions such as speech. The sensory branches mediate sensation from the pharynx, larynx, thorax and abdomen; it also innervates taste buds in the epiglottis." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] synonym: "CN X biosynthesis" RELATED [] synonym: "CN X formation" RELATED [] is_a: GO:0021603 ! cranial nerve formation intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0001759 ! results in formation of anatomical entity vagus nerve relationship: BFO:0000050 GO:0021644 ! part of vagus nerve morphogenesis relationship: RO:0002297 UBERON:0001759 ! results in formation of anatomical entity vagus nerve [Term] id: GO:0021647 name: vestibulocochlear nerve maturation namespace: biological_process def: "A developmental process, independent of morphogenetic (shape) change, that is required for the vestibulocochlear nerve to attain its fully functional state. This sensory nerve innervates the membranous labyrinth of the inner ear. The vestibular branch innervates the vestibular apparatus that senses head position changes relative to gravity. The auditory branch innervates the cochlear duct, which is connected to the three bony ossicles which transduce sound waves into fluid movement in the cochlea." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] synonym: "auditory nerve maturation" RELATED [] synonym: "CN VIII maturation" RELATED [] is_a: GO:0021605 ! cranial nerve maturation intersection_of: GO:0021700 ! developmental maturation intersection_of: RO:0002299 UBERON:0001648 ! results in maturation of vestibulocochlear nerve relationship: BFO:0000050 GO:0021562 ! part of vestibulocochlear nerve development relationship: RO:0002299 UBERON:0001648 ! results in maturation of vestibulocochlear nerve [Term] id: GO:0021648 name: vestibulocochlear nerve morphogenesis namespace: biological_process def: "The process in which the anatomical structure of the vestibulocochlear nerve is generated and organized. This sensory nerve innervates the membranous labyrinth of the inner ear. The vestibular branch innervates the vestibular apparatus that senses head position changes relative to gravity. The auditory branch innervates the cochlear duct, which is connected to the three bony ossicles which transduce sound waves into fluid movement in the cochlea." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] synonym: "CN VIII morphogenesis" RELATED [] is_a: GO:0021602 ! cranial nerve morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0001648 ! results in morphogenesis of vestibulocochlear nerve relationship: BFO:0000050 GO:0021562 ! part of vestibulocochlear nerve development relationship: RO:0002298 UBERON:0001648 ! results in morphogenesis of vestibulocochlear nerve [Term] id: GO:0021650 name: vestibulocochlear nerve formation namespace: biological_process def: "The process that gives rise to the vestibulocochlear nerve. This process pertains to the initial formation of a structure from unspecified parts. This sensory nerve innervates the membranous labyrinth of the inner ear. The vestibular branch innervates the vestibular apparatus that senses head position changes relative to gravity. The auditory branch innervates the cochlear duct, which is connected to the three bony ossicles which transduce sound waves into fluid movement in the cochlea." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] synonym: "CN VII formation" RELATED [] is_a: GO:0021603 ! cranial nerve formation intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0001648 ! results in formation of anatomical entity vestibulocochlear nerve relationship: BFO:0000050 GO:0021648 ! part of vestibulocochlear nerve morphogenesis relationship: RO:0002297 UBERON:0001648 ! results in formation of anatomical entity vestibulocochlear nerve [Term] id: GO:0021651 name: rhombomere 1 morphogenesis namespace: biological_process def: "The process in which the anatomical structure of rhombomere 1 is generated and organized. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in an anterior to posterior order." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid] is_a: GO:0021593 ! rhombomere morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0005499 ! results in morphogenesis of rhombomere 1 relationship: BFO:0000050 GO:0021567 ! part of rhombomere 1 development relationship: RO:0002298 UBERON:0005499 ! results in morphogenesis of rhombomere 1 [Term] id: GO:0021652 name: rhombomere 1 formation namespace: biological_process def: "The process that gives rise to rhombomere 1. This process pertains to the initial formation of a structure from unspecified parts. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid] is_a: GO:0021594 ! rhombomere formation intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0005499 ! results in formation of anatomical entity rhombomere 1 relationship: BFO:0000050 GO:0021651 ! part of rhombomere 1 morphogenesis relationship: RO:0002297 UBERON:0005499 ! results in formation of anatomical entity rhombomere 1 [Term] id: GO:0021654 name: rhombomere boundary formation namespace: biological_process def: "The process that gives rise to a rhombomere boundary. This process pertains to the initial formation of a boundary delimiting a rhombomere. Rhombomeres are transverse segments of the developing rhombencephalon that are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid] is_a: GO:0048859 ! formation of anatomical boundary intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0018239 ! results in formation of anatomical entity rhombomere boundary relationship: BFO:0000050 GO:0021594 ! part of rhombomere formation relationship: RO:0002297 UBERON:0018239 ! results in formation of anatomical entity rhombomere boundary [Term] id: GO:0021670 name: lateral ventricle development namespace: biological_process def: "The process whose specific outcome is the progression of the lateral ventricles over time, from the formation to the mature structure. The two lateral ventricles are a cavity in each of the cerebral hemispheres derived from the cavity of the embryonic neural tube. They are separated from each other by the septum pellucidum, and each communicates with the third ventricle by the foramen of Monro, through which also the choroid plexuses of the lateral ventricles become continuous with that of the third ventricle." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] is_a: GO:0048856 ! anatomical structure development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0002285 ! results in development of telencephalic ventricle relationship: BFO:0000050 GO:0021537 ! part of telencephalon development relationship: BFO:0000050 GO:0021591 ! part of ventricular system development relationship: RO:0002296 UBERON:0002285 ! results in development of telencephalic ventricle [Term] id: GO:0021675 name: nerve development namespace: biological_process def: "The process whose specific outcome is the progression of a nerve over time, from its formation to the mature structure." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid] is_a: GO:0048856 ! anatomical structure development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0001021 ! results in development of nerve relationship: BFO:0000050 GO:0007399 ! part of nervous system development relationship: RO:0002296 UBERON:0001021 ! results in development of nerve [Term] id: GO:0021678 name: third ventricle development namespace: biological_process def: "The process whose specific outcome is the progression of the third ventricle over time, from its formation to the mature structure. The third ventricle is the narrow cleft inferior to the corpus callosum, within the diencephalon, between the paired thalami. Its floor is formed by the hypothalamus, its anterior wall by the lamina terminalis, and its roof by ependyma, and it communicates with the fourth ventricle by the cerebral aqueduct, and with the lateral ventricles by the interventricular foramina." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] is_a: GO:0048856 ! anatomical structure development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0002286 ! results in development of third ventricle relationship: BFO:0000050 GO:0021591 ! part of ventricular system development relationship: RO:0002162 NCBITaxon:89593 ! in taxon Craniata relationship: RO:0002296 UBERON:0002286 ! results in development of third ventricle [Term] id: GO:0021679 name: cerebellar molecular layer development namespace: biological_process def: "The process whose specific outcome is the progression of the cerebellar molecular layer nerve over time, from its formation to the mature structure. The molecular layer is the outermost layer of the cerebellar cortex. It contains the parallel fibers of the granule cells, interneurons such as stellate and basket cells, and the dendrites of the underlying Purkinje cells." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] is_a: GO:0048856 ! anatomical structure development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0002974 ! results in development of molecular layer of cerebellar cortex relationship: BFO:0000050 GO:0021695 ! part of cerebellar cortex development relationship: RO:0002296 UBERON:0002974 ! results in development of molecular layer of cerebellar cortex [Term] id: GO:0021680 name: cerebellar Purkinje cell layer development namespace: biological_process def: "The process whose specific outcome is the progression of the cerebellar Purkinje cell layer over time, from its formation to the mature structure. The Purkinje cell layer lies just underneath the molecular layer of the cerebellar cortex. It contains the neuronal cell bodies of the Purkinje cells that are arranged side by side in a single layer. Candelabrum interneurons are vertically oriented between the Purkinje cells. Purkinje neurons are inhibitory and provide the output of the cerebellar cortex through axons that project into the white matter. Extensive dendritic trees from the Purkinje cells extend upward in a single plane into the molecular layer where they synapse with parallel fibers of granule cells." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] is_a: GO:0048856 ! anatomical structure development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0002979 ! results in development of Purkinje cell layer of cerebellar cortex relationship: BFO:0000050 GO:0021695 ! part of cerebellar cortex development relationship: RO:0002296 UBERON:0002979 ! results in development of Purkinje cell layer of cerebellar cortex [Term] id: GO:0021681 name: cerebellar granular layer development namespace: biological_process def: "The process whose specific outcome is the progression of the cerebellar granule layer over time, from its formation to the mature structure. The granular layer is the innermost layer of the cerebellar cortex. This layer contains densely packed small neurons, mostly granule cells. Some Golgi cells are found at the outer border. Granule neurons send parallel fibers to the upper molecular layer, where they synapse with Purkinje cell dendrites. Mossy fibers from the pontine nuclei in the white matter synapse with granule cell axons, Golgi cell axons and unipolar brush interneuron axons at cerebellar glomeruli in the granule cell layer." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] is_a: GO:0048856 ! anatomical structure development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0002956 ! results in development of granular layer of cerebellar cortex relationship: BFO:0000050 GO:0021695 ! part of cerebellar cortex development relationship: RO:0002296 UBERON:0002956 ! results in development of granular layer of cerebellar cortex [Term] id: GO:0021682 name: nerve maturation namespace: biological_process def: "A developmental process, independent of morphogenetic (shape) change, that is required for a nerve to attain its fully functional state." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid] is_a: GO:0071695 ! anatomical structure maturation intersection_of: GO:0021700 ! developmental maturation intersection_of: RO:0002299 UBERON:0001021 ! results in maturation of nerve relationship: BFO:0000050 GO:0021675 ! part of nerve development relationship: RO:0002299 UBERON:0001021 ! results in maturation of nerve [Term] id: GO:0021683 name: cerebellar granular layer morphogenesis namespace: biological_process def: "The process in which the anatomical structure of the cerebellar granular layer is generated and organized. The granular layer is the innermost layer of the cerebellar cortex. This layer contains densely packed small neurons, mostly granule cells. Some Golgi cells are found at the outer border. Granule neurons send parallel fibers to the upper molecular layer, where they synapse with Purkinje cell dendrites. Mossy fibers from the pontine nuclei in the white matter synapse with granule cell axons, Golgi cell axons and unipolar brush interneuron axons at cerebellar glomeruli in the granule cell layer." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] is_a: BFO:0000003 is_a: GO:0009653 ! anatomical structure morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0002956 ! results in morphogenesis of granular layer of cerebellar cortex relationship: BFO:0000050 GO:0021681 ! part of cerebellar granular layer development relationship: BFO:0000050 GO:0021696 ! part of cerebellar cortex morphogenesis relationship: RO:0002298 UBERON:0002956 ! results in morphogenesis of granular layer of cerebellar cortex [Term] id: GO:0021684 name: cerebellar granular layer formation namespace: biological_process def: "The process that gives rise to the cerebellar granule layer. This process pertains to the initial formation of a structure from unspecified parts. The granular layer is the innermost layer of the cerebellar cortex. This layer contains densely packed small neurons, mostly granule cells. Some Golgi cells are found at the outer border. Granule neurons send parallel fibers to the upper molecular layer, where they synapse with Purkinje cell dendrites. Mossy fibers from the pontine nuclei in the white matter synapse with granule cell axons, Golgi cell axons and unipolar brush interneuron axons at cerebellar glomeruli in the granule cell layer." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] is_a: BFO:0000003 is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0002956 ! results in formation of anatomical entity granular layer of cerebellar cortex relationship: BFO:0000050 GO:0021683 ! part of cerebellar granular layer morphogenesis relationship: BFO:0000050 GO:0021697 ! part of cerebellar cortex formation relationship: RO:0002297 UBERON:0002956 ! results in formation of anatomical entity granular layer of cerebellar cortex [Term] id: GO:0021686 name: cerebellar granular layer maturation namespace: biological_process def: "A developmental process, independent of morphogenetic (shape) change, that is required for the cerebellar granular layer to attain its fully functional state. The granular layer is the innermost layer of the cerebellar cortex. This layer contains densely packed small neurons, mostly granule cells. Some Golgi cells are found at the outer border. Granule neurons send parallel fibers to the upper molecular layer, where they synapse with Purkinje cell dendrites. Mossy fibers from the pontine nuclei in the white matter synapse with granule cell axons, Golgi cell axons and unipolar brush interneuron axons at cerebellar glomeruli in the granule cell layer." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] is_a: GO:0071695 ! anatomical structure maturation intersection_of: GO:0021700 ! developmental maturation intersection_of: RO:0002299 UBERON:0002956 ! results in maturation of granular layer of cerebellar cortex relationship: BFO:0000050 GO:0021681 ! part of cerebellar granular layer development relationship: BFO:0000050 GO:0021699 ! part of cerebellar cortex maturation relationship: RO:0002299 UBERON:0002956 ! results in maturation of granular layer of cerebellar cortex [Term] id: GO:0021687 name: cerebellar molecular layer morphogenesis namespace: biological_process def: "The process in which the anatomical structure of the cerebellar molecular layer is generated and organized. The molecular layer is the outermost layer of the cerebellar cortex. It contains the parallel fibers of the granule cells, interneurons such as stellate and basket cells, and the dendrites of the underlying Purkinje cells." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] is_a: BFO:0000003 is_a: GO:0009653 ! anatomical structure morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0002974 ! results in morphogenesis of molecular layer of cerebellar cortex relationship: BFO:0000050 GO:0021679 ! part of cerebellar molecular layer development relationship: BFO:0000050 GO:0021696 ! part of cerebellar cortex morphogenesis relationship: RO:0002298 UBERON:0002974 ! results in morphogenesis of molecular layer of cerebellar cortex [Term] id: GO:0021688 name: cerebellar molecular layer formation namespace: biological_process def: "The process that gives rise to the cerebellar molecular layer. This process pertains to the initial formation of a structure from unspecified parts. The molecular layer is the outermost layer of the cerebellar cortex. It contains the parallel fibers of the granule cells, interneurons such as stellate and basket cells, and the dendrites of the underlying Purkinje cells." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] is_a: BFO:0000003 is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0002974 ! results in formation of anatomical entity molecular layer of cerebellar cortex relationship: BFO:0000050 GO:0021687 ! part of cerebellar molecular layer morphogenesis relationship: BFO:0000050 GO:0021697 ! part of cerebellar cortex formation relationship: RO:0002297 UBERON:0002974 ! results in formation of anatomical entity molecular layer of cerebellar cortex [Term] id: GO:0021690 name: cerebellar molecular layer maturation namespace: biological_process def: "A developmental process, independent of morphogenetic (shape) change, that is required for the cerebellar molecular layer to attain its fully functional state. The molecular layer is the outermost layer of the cerebellar cortex. It contains the parallel fibers of the granule cells, interneurons such as stellate and basket cells, and the dendrites of the underlying Purkinje cells." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] is_a: GO:0071695 ! anatomical structure maturation intersection_of: GO:0021700 ! developmental maturation intersection_of: RO:0002299 UBERON:0002974 ! results in maturation of molecular layer of cerebellar cortex relationship: BFO:0000050 GO:0021679 ! part of cerebellar molecular layer development relationship: BFO:0000050 GO:0021699 ! part of cerebellar cortex maturation relationship: RO:0002299 UBERON:0002974 ! results in maturation of molecular layer of cerebellar cortex [Term] id: GO:0021691 name: cerebellar Purkinje cell layer maturation namespace: biological_process def: "A developmental process, independent of morphogenetic (shape) change, that is required for the cerebellar Purkinje cell layer to attain its fully functional state. The Purkinje cell layer lies just underneath the molecular layer of the cerebellar cortex. It contains the neuronal cell bodies of the Purkinje cells that are arranged side by side in a single layer. Candelabrum interneurons are vertically oriented between the Purkinje cells. Purkinje neurons are inhibitory and provide the output of the cerebellar cortex through axons that project into the white matter. Extensive dendritic trees from the Purkinje cells extend upward in a single plane into the molecular layer where they synapse with parallel fibers of granule cells." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] is_a: GO:0071695 ! anatomical structure maturation intersection_of: GO:0021700 ! developmental maturation intersection_of: RO:0002299 UBERON:0002979 ! results in maturation of Purkinje cell layer of cerebellar cortex relationship: BFO:0000050 GO:0021680 ! part of cerebellar Purkinje cell layer development relationship: BFO:0000050 GO:0021699 ! part of cerebellar cortex maturation relationship: RO:0002299 UBERON:0002979 ! results in maturation of Purkinje cell layer of cerebellar cortex [Term] id: GO:0021692 name: cerebellar Purkinje cell layer morphogenesis namespace: biological_process def: "The process in which the anatomical structure of the cerebellar Purkinje cell layer is generated and organized. The Purkinje cell layer lies just underneath the molecular layer of the cerebellar cortex. It contains the neuronal cell bodies of the Purkinje cells that are arranged side by side in a single layer. Candelabrum interneurons are vertically oriented between the Purkinje cells. Purkinje neurons are inhibitory and provide the output of the cerebellar cortex through axons that project into the white matter. Extensive dendritic trees from the Purkinje cells extend upward in a single plane into the molecular layer where they synapse with parallel fibers of granule cells." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] is_a: BFO:0000003 is_a: GO:0009653 ! anatomical structure morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0002979 ! results in morphogenesis of Purkinje cell layer of cerebellar cortex relationship: BFO:0000050 GO:0021680 ! part of cerebellar Purkinje cell layer development relationship: BFO:0000050 GO:0021696 ! part of cerebellar cortex morphogenesis relationship: RO:0002298 UBERON:0002979 ! results in morphogenesis of Purkinje cell layer of cerebellar cortex [Term] id: GO:0021694 name: cerebellar Purkinje cell layer formation namespace: biological_process def: "The process that gives rise to the cerebellar Purkinje cell layer. This process pertains to the initial formation of a structure from unspecified parts. The Purkinje cell layer lies just underneath the molecular layer of the cerebellar cortex. It contains the neuronal cell bodies of the Purkinje cells that are arranged side by side in a single layer. Candelabrum interneurons are vertically oriented between the Purkinje cells. Purkinje neurons are inhibitory and provide the output of the cerebellar cortex through axons that project into the white matter. Extensive dendritic trees from the Purkinje cells extend upward in a single plane into the molecular layer where they synapse with parallel fibers of granule cells." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] is_a: BFO:0000003 is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0002979 ! results in formation of anatomical entity Purkinje cell layer of cerebellar cortex relationship: BFO:0000050 GO:0021692 ! part of cerebellar Purkinje cell layer morphogenesis relationship: BFO:0000050 GO:0021697 ! part of cerebellar cortex formation relationship: RO:0002297 UBERON:0002979 ! results in formation of anatomical entity Purkinje cell layer of cerebellar cortex [Term] id: GO:0021695 name: cerebellar cortex development namespace: biological_process def: "The process whose specific outcome is the progression of the cerebellar cortex over time, from its formation to the mature structure. The cerebellar cortex is a thin mantle of gray matter that covers the surface of each cerebral hemisphere. It has a characteristic morphology with convolutions (gyri) and crevices (sulci) that have specific functions. Six layers of nerve cells and the nerve pathways that connect them comprise the cerebellar cortex. Together, these regions are responsible for the processes of conscious thought, perception, emotion and memory as well as advanced motor function." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] is_a: GO:0048856 ! anatomical structure development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0002129 ! results in development of cerebellar cortex relationship: BFO:0000050 GO:0021549 ! part of cerebellum development relationship: RO:0002296 UBERON:0002129 ! results in development of cerebellar cortex [Term] id: GO:0021696 name: cerebellar cortex morphogenesis namespace: biological_process def: "The process in which the anatomical structure of the cranial nerves are generated and organized. The cerebellar cortex is a thin mantle of gray matter that covers the surface of each cerebral hemisphere. It has a characteristic morphology with convolutions (gyri) and crevices (sulci) that have specific functions. Six layers of nerve cells and the nerve pathways that connect them comprise the cerebellar cortex. Together, these regions are responsible for the processes of conscious thought, perception, emotion and memory as well as advanced motor function." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] is_a: BFO:0000003 is_a: GO:0009653 ! anatomical structure morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0002129 ! results in morphogenesis of cerebellar cortex relationship: BFO:0000050 GO:0021587 ! part of cerebellum morphogenesis relationship: BFO:0000050 GO:0021695 ! part of cerebellar cortex development relationship: RO:0002298 UBERON:0002129 ! results in morphogenesis of cerebellar cortex [Term] id: GO:0021697 name: cerebellar cortex formation namespace: biological_process def: "The process that gives rise to the cerebellar cortex. This process pertains to the initial formation of a structure from unspecified parts. The cerebellar cortex is a thin mantle of gray matter that covers the surface of each cerebral hemisphere. It has a characteristic morphology with convolutions (gyri) and crevices (sulci) that have specific functions. Six layers of nerve cells and the nerve pathways that connect them comprise the cerebellar cortex. Together, these regions are responsible for the processes of conscious thought, perception, emotion and memory as well as advanced motor function." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] is_a: BFO:0000003 is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0002129 ! results in formation of anatomical entity cerebellar cortex relationship: BFO:0000050 GO:0021696 ! part of cerebellar cortex morphogenesis relationship: RO:0002297 UBERON:0002129 ! results in formation of anatomical entity cerebellar cortex [Term] id: GO:0021699 name: cerebellar cortex maturation namespace: biological_process def: "A developmental process, independent of morphogenetic (shape) change, that is required for the cerebellar cortex to attain its fully functional state. The cerebellar cortex is a thin mantle of gray matter that covers the surface of each cerebral hemisphere. It has a characteristic morphology with convolutions (gyri) and crevices (sulci) that have specific functions. Six layers of nerve cells and the nerve pathways that connect them comprise the cerebellar cortex. Together, these regions are responsible for the processes of conscious thought, perception, emotion and memory as well as advanced motor function." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] is_a: GO:0071695 ! anatomical structure maturation intersection_of: GO:0021700 ! developmental maturation intersection_of: RO:0002299 UBERON:0002129 ! results in maturation of cerebellar cortex relationship: BFO:0000050 GO:0021590 ! part of cerebellum maturation relationship: BFO:0000050 GO:0021695 ! part of cerebellar cortex development relationship: RO:0002299 UBERON:0002129 ! results in maturation of cerebellar cortex [Term] id: GO:0021700 name: developmental maturation namespace: biological_process def: "A developmental process, independent of morphogenetic (shape) change, that is required for an anatomical structure, cell or cellular component to attain its fully functional state." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid] subset: goslim_chembl is_a: GO:0032502 ! developmental process [Term] id: GO:0021701 name: cerebellar Golgi cell differentiation namespace: biological_process def: "The process in which neuroblasts acquire specialized structural and/or functional features that characterize the mature cerebellar Golgi cell. Differentiation includes the processes involved in commitment of a neuroblast to a Golgi cell fate. A cerebellar Golgi cell is an inhibitory GABAergic interneuron found in the cerebellar cortex." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:15157725] is_a: GO:0021533 ! cell differentiation in hindbrain is_a: GO:0021953 ! central nervous system neuron differentiation is_a: GO:0097154 ! GABAergic neuron differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000119 ! results in acquisition of features of cerebellar Golgi cell relationship: BFO:0000050 GO:0021684 ! part of cerebellar granular layer formation relationship: RO:0002315 CL:0000119 ! results in acquisition of features of cerebellar Golgi cell [Term] id: GO:0021702 name: cerebellar Purkinje cell differentiation namespace: biological_process def: "The process in which neuroblasts acquire specialized structural and/or functional features that characterize the mature cerebellar Purkinje cell. Differentiation includes the processes involved in commitment of a neuroblast to a Purkinje cell fate. A Purkinje cell is an inhibitory GABAergic neuron found in the cerebellar cortex that projects to the deep cerebellar nuclei and brain stem." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:15157725] is_a: GO:0021533 ! cell differentiation in hindbrain is_a: GO:0021953 ! central nervous system neuron differentiation is_a: GO:0097154 ! GABAergic neuron differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000121 ! results in acquisition of features of Purkinje cell relationship: BFO:0000050 GO:0021694 ! part of cerebellar Purkinje cell layer formation relationship: RO:0002315 CL:0000121 ! results in acquisition of features of Purkinje cell [Term] id: GO:0021703 name: locus ceruleus development namespace: biological_process def: "The process whose specific outcome is the progression of the locus ceruleus over time, from its formation to the mature structure. The locus ceruleus is a dense cluster of neurons within the dorsorostral pons. This nucleus is the major location of neurons that release norepinephrine throughout the brain, and is responsible for physiological responses to stress and panic." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] synonym: "locus caeruleus development" EXACT [] synonym: "locus coeruleus development" EXACT [] is_a: GO:0048857 ! neural nucleus development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0002148 ! results in development of locus ceruleus relationship: BFO:0000050 GO:0021548 ! part of pons development relationship: RO:0002296 UBERON:0002148 ! results in development of locus ceruleus [Term] id: GO:0021704 name: locus ceruleus morphogenesis namespace: biological_process def: "The process in which the anatomical structure of the locus ceruleus is generated and organized. In mice, the locus ceruleus is a dense cluster of neurons within the dorsorostral pons. This nucleus is the major location of neurons that release norepinephrine throughout the brain, and is responsible for physiological responses to stress and panic." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] is_a: BFO:0000003 is_a: GO:0009653 ! anatomical structure morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0002148 ! results in morphogenesis of locus ceruleus relationship: BFO:0000050 GO:0021583 ! part of pons morphogenesis relationship: BFO:0000050 GO:0021703 ! part of locus ceruleus development relationship: RO:0002298 UBERON:0002148 ! results in morphogenesis of locus ceruleus [Term] id: GO:0021705 name: locus ceruleus formation namespace: biological_process def: "The process that gives rise to the locus ceruleus. This process pertains to the initial formation of a structure from unspecified parts. In mice, the locus ceruleus is a dense cluster of neurons within the dorsorostral pons. This nucleus is the major location of neurons that release norepinephrine throughout the brain, and is responsible for physiological responses to stress and panic." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] is_a: BFO:0000003 is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0002148 ! results in formation of anatomical entity locus ceruleus relationship: BFO:0000050 GO:0021584 ! part of pons formation relationship: BFO:0000050 GO:0021704 ! part of locus ceruleus morphogenesis relationship: RO:0002297 UBERON:0002148 ! results in formation of anatomical entity locus ceruleus [Term] id: GO:0021706 name: locus ceruleus maturation namespace: biological_process def: "A developmental process, independent of morphogenetic (shape) change, that is required for the locus ceruleus to attain its fully functional state. The locus ceruleus is a dense cluster of neurons within the dorsorostral pons. This nucleus is the major location of neurons that release norepinephrine throughout the brain, and is responsible for physiological responses to stress and panic." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] is_a: GO:0071695 ! anatomical structure maturation intersection_of: GO:0021700 ! developmental maturation intersection_of: RO:0002299 UBERON:0002148 ! results in maturation of locus ceruleus relationship: BFO:0000050 GO:0021586 ! part of pons maturation relationship: BFO:0000050 GO:0021703 ! part of locus ceruleus development relationship: RO:0002299 UBERON:0002148 ! results in maturation of locus ceruleus [Term] id: GO:0021707 name: cerebellar granule cell differentiation namespace: biological_process def: "The process in which neuroblasts acquire specialized structural and/or functional features that characterize the mature cerebellar granule cell. Differentiation includes the processes involved in commitment of a neuroblast to a granule cell fate. A granule cell is a glutamatergic interneuron found in the cerebellar cortex." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:15157725] is_a: GO:0021533 ! cell differentiation in hindbrain is_a: GO:0021953 ! central nervous system neuron differentiation is_a: GO:1905962 ! glutamatergic neuron differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0001031 ! results in acquisition of features of cerebellar granule cell relationship: BFO:0000050 GO:0021684 ! part of cerebellar granular layer formation relationship: RO:0002315 CL:0001031 ! results in acquisition of features of cerebellar granule cell [Term] id: GO:0021708 name: Lugaro cell differentiation namespace: biological_process def: "The process in which neuroblasts acquire specialized structural and/or functional features that characterize the mature Lugaro cell. Differentiation includes the processes involved in commitment of a neuroblast to a Lugaro cell fate. A Lugaro cell is an inhibitory GABAergic interneuron found in the cerebellar cortex." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:15157725] is_a: GO:0021533 ! cell differentiation in hindbrain is_a: GO:0021953 ! central nervous system neuron differentiation is_a: GO:0097154 ! GABAergic neuron differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0011006 ! results in acquisition of features of Lugaro cell relationship: BFO:0000050 GO:0021697 ! part of cerebellar cortex formation relationship: RO:0002315 CL:0011006 ! results in acquisition of features of Lugaro cell [Term] id: GO:0021710 name: cerebellar stellate cell differentiation namespace: biological_process def: "The process in which neuroblasts acquire specialized structural and/or functional features that characterize the mature cerebellar stellate cell. Differentiation includes the processes involved in commitment of a neuroblast to a cerebellar stellate cell fate. A cerebellar stellate cell is an inhibitory GABAergic interneuron found in the cerebellar cortex." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:15157725] is_a: GO:0021533 ! cell differentiation in hindbrain is_a: GO:0021953 ! central nervous system neuron differentiation is_a: GO:0097154 ! GABAergic neuron differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0010010 ! results in acquisition of features of cerebellar stellate cell relationship: BFO:0000050 GO:0021688 ! part of cerebellar molecular layer formation relationship: RO:0002315 CL:0010010 ! results in acquisition of features of cerebellar stellate cell [Term] id: GO:0021718 name: superior olivary nucleus development namespace: biological_process def: "The process whose specific outcome is the progression of the superior olivary nucleus over time, from its formation to the mature structure. In mice, the superior olivary nucleus is a small cylindrical mass on the dorsal surface of the lateral part of the trapezoid body of the pons, and it is situated immediately above the inferior olivary nucleus. It receives projections from the cochlear nucleus and thus is involved in the perception of sound." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] synonym: "superior olive development" RELATED [] is_a: GO:0048857 ! neural nucleus development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0007247 ! results in development of nucleus of superior olivary complex relationship: BFO:0000050 GO:0021548 ! part of pons development relationship: RO:0002296 UBERON:0007247 ! results in development of nucleus of superior olivary complex [Term] id: GO:0021719 name: superior olivary nucleus morphogenesis namespace: biological_process def: "The process in which the anatomical structure of the superior olivary nucleus is generated and organized. In mice, the superior olivary nucleus is a small cylindrical mass on the dorsal surface of the lateral part of the trapezoid body of the pons, and it is situated immediately above the inferior olivary nucleus. It receives projections from the cochlear nucleus and thus is involved in the perception of sound." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] synonym: "superior olive morphogenesis" RELATED [] is_a: BFO:0000003 is_a: GO:0009653 ! anatomical structure morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0007247 ! results in morphogenesis of nucleus of superior olivary complex relationship: BFO:0000050 GO:0021583 ! part of pons morphogenesis relationship: BFO:0000050 GO:0021718 ! part of superior olivary nucleus development relationship: RO:0002298 UBERON:0007247 ! results in morphogenesis of nucleus of superior olivary complex [Term] id: GO:0021720 name: superior olivary nucleus formation namespace: biological_process def: "The process that gives rise to the superior olivary nucleus. This process pertains to the initial formation of a structure from unspecified parts. In mice, the superior olivary nucleus is a small cylindrical mass on the dorsal surface of the lateral part of the trapezoid body of the pons, and it is situated immediately above the inferior olivary nucleus. It receives projections from the cochlear nucleus and thus is involved in the perception of sound." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] is_a: BFO:0000003 is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0007247 ! results in formation of anatomical entity nucleus of superior olivary complex relationship: BFO:0000050 GO:0021584 ! part of pons formation relationship: BFO:0000050 GO:0021719 ! part of superior olivary nucleus morphogenesis relationship: RO:0002297 UBERON:0007247 ! results in formation of anatomical entity nucleus of superior olivary complex [Term] id: GO:0021722 name: superior olivary nucleus maturation namespace: biological_process def: "A developmental process, independent of morphogenetic (shape) change, that is required for the superior olivary nucleus to attain its fully functional state. The superior olivary nucleus is a small cylindrical mass on the dorsal surface of the lateral part of the trapezoid body of the pons, and it is situated immediately above the inferior olivary nucleus. It receives projections from the cochlear nucleus and thus is involved in the perception of sound." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] synonym: "superior olive maturation" RELATED [] is_a: GO:0071695 ! anatomical structure maturation intersection_of: GO:0021700 ! developmental maturation intersection_of: RO:0002299 UBERON:0007247 ! results in maturation of nucleus of superior olivary complex relationship: BFO:0000050 GO:0021586 ! part of pons maturation relationship: BFO:0000050 GO:0021718 ! part of superior olivary nucleus development relationship: RO:0002299 UBERON:0007247 ! results in maturation of nucleus of superior olivary complex [Term] id: GO:0021732 name: midbrain-hindbrain boundary maturation namespace: biological_process def: "A developmental process, independent of morphogenetic (shape) change, that is required for the midbrain-hindbrain boundary to attain its fully functional state. The midbrain-hindbrain domain of the embryonic brain is comprised of the mesencephalic vesicle and the first rhombencephalic vesicle at early somitogenesis stages. An organizing center at the boundary patterns the midbrain and hindbrain primordia of the neural plate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:15541513] synonym: "isthmus maturation" RELATED [] synonym: "MHB maturation" RELATED [] is_a: GO:0071695 ! anatomical structure maturation intersection_of: GO:0021700 ! developmental maturation intersection_of: RO:0002299 UBERON:0003052 ! results in maturation of midbrain-hindbrain boundary relationship: BFO:0000050 GO:0030917 ! part of midbrain-hindbrain boundary development relationship: RO:0002299 UBERON:0003052 ! results in maturation of midbrain-hindbrain boundary [Term] id: GO:0021743 name: hypoglossal nucleus development namespace: biological_process def: "The process whose specific outcome is the progression of the hypoglossal nucleus over time, from its formation to the mature structure." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid] is_a: GO:0048857 ! neural nucleus development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0002871 ! results in development of hypoglossal nucleus relationship: BFO:0000050 GO:0021550 ! part of medulla oblongata development relationship: RO:0002296 UBERON:0002871 ! results in development of hypoglossal nucleus [Term] id: GO:0021747 name: cochlear nucleus development namespace: biological_process def: "The process whose specific outcome is the progression of the cochlear nucleus over time, from its formation to the mature structure." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid] is_a: GO:0048857 ! neural nucleus development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0001720 ! results in development of cochlear nucleus relationship: BFO:0000050 GO:0021548 ! part of pons development relationship: RO:0002296 UBERON:0001720 ! results in development of cochlear nucleus [Term] id: GO:0021748 name: dorsal cochlear nucleus development namespace: biological_process def: "The process whose specific outcome is the progression of the dorsal cochlear nucleus over time, from its formation to the mature structure." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid] is_a: GO:0021747 ! cochlear nucleus development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0002829 ! results in development of dorsal cochlear nucleus relationship: RO:0002296 UBERON:0002829 ! results in development of dorsal cochlear nucleus [Term] id: GO:0021749 name: ventral cochlear nucleus development namespace: biological_process def: "The process whose specific outcome is the progression of the ventral cochlear nucleus over time, from its formation to the mature structure." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid] is_a: GO:0021747 ! cochlear nucleus development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0002828 ! results in development of ventral cochlear nucleus relationship: RO:0002296 UBERON:0002828 ! results in development of ventral cochlear nucleus [Term] id: GO:0021750 name: vestibular nucleus development namespace: biological_process def: "The process whose specific outcome is the progression of the vestibular nucleus over time, from its formation to the mature structure." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, PMID:16221589] is_a: GO:0048857 ! neural nucleus development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0002673 ! results in development of vestibular nuclear complex relationship: BFO:0000050 GO:0021548 ! part of pons development relationship: BFO:0000050 GO:0021550 ! part of medulla oblongata development relationship: RO:0002296 UBERON:0002673 ! results in development of vestibular nuclear complex [Term] id: GO:0021751 name: salivary nucleus development namespace: biological_process def: "The process whose specific outcome is the progression of a salivary nucleus over time, from its formation to the mature structure." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid] is_a: GO:0048857 ! neural nucleus development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0004133 ! results in development of salivatory nucleus relationship: BFO:0000050 GO:0021548 ! part of pons development relationship: RO:0002296 UBERON:0004133 ! results in development of salivatory nucleus [Term] id: GO:0021753 name: superior salivary nucleus development namespace: biological_process def: "The process whose specific outcome is the progression of the superior salivary nucleus over time, from its formation to the mature structure." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid] is_a: GO:0021751 ! salivary nucleus development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0002149 ! results in development of superior salivatory nucleus relationship: RO:0002296 UBERON:0002149 ! results in development of superior salivatory nucleus [Term] id: GO:0021754 name: facial nucleus development namespace: biological_process def: "The process whose specific outcome is the progression of the facial nucleus over time, from its formation to the mature structure." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid] is_a: GO:0048857 ! neural nucleus development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0000127 ! results in development of facial nucleus relationship: BFO:0000050 GO:0021548 ! part of pons development relationship: RO:0002296 UBERON:0000127 ! results in development of facial nucleus [Term] id: GO:0021755 name: eurydendroid cell differentiation namespace: biological_process def: "The process in which neuroblasts acquire specialized structural and/or functional features that characterize the mature eurydendroid cell. Differentiation includes the processes involved in commitment of a neuroblast to a eurydendroid cell fate. A eurydendroid cell is an efferent neuron found in the cerebellar cortex of teleosts." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:15892096] is_a: GO:0021533 ! cell differentiation in hindbrain is_a: GO:0021953 ! central nervous system neuron differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000253 ! results in acquisition of features of eurydendroid cell relationship: BFO:0000050 GO:0021697 ! part of cerebellar cortex formation relationship: RO:0002315 CL:0000253 ! results in acquisition of features of eurydendroid cell [Term] id: GO:0021756 name: striatum development namespace: biological_process def: "The progression of the striatum over time from its initial formation until its mature state. The striatum is a region of the forebrain consisting of the caudate nucleus, putamen and fundus striati." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0878937420] synonym: "neostriatum development" EXACT [] synonym: "striate nucleus development" EXACT [] is_a: GO:0048856 ! anatomical structure development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0002435 ! results in development of striatum relationship: BFO:0000050 GO:0021544 ! part of subpallium development relationship: RO:0002162 NCBITaxon:89593 ! in taxon Craniata relationship: RO:0002296 UBERON:0002435 ! results in development of striatum [Term] id: GO:0021757 name: caudate nucleus development namespace: biological_process def: "The progression of the caudate nucleus over time from its initial formation until its mature state. The caudate nucleus is the C-shaped structures of the striatum containing input neurons involved with control of voluntary movement in the brain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0878937420] is_a: GO:0048857 ! neural nucleus development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0001873 ! results in development of caudate nucleus relationship: BFO:0000050 GO:0021756 ! part of striatum development relationship: RO:0002296 UBERON:0001873 ! results in development of caudate nucleus [Term] id: GO:0021758 name: putamen development namespace: biological_process def: "The progression of the putamen over time from its initial formation until its mature state. The putamen is the lens-shaped basal ganglion involved with control of voluntary movement in the brain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0878937420] is_a: GO:0048857 ! neural nucleus development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0001874 ! results in development of putamen relationship: BFO:0000050 GO:0021756 ! part of striatum development relationship: RO:0002296 UBERON:0001874 ! results in development of putamen [Term] id: GO:0021759 name: globus pallidus development namespace: biological_process def: "The progression of the globus pallidus over time from its initial formation until its mature state. The globus pallidus is one of the basal ganglia involved with control of voluntary movement in the brain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0878937420] synonym: "pallidum development" EXACT [PMID:16271465] is_a: GO:0048857 ! neural nucleus development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0001875 ! results in development of globus pallidus relationship: BFO:0000050 GO:0021536 ! part of diencephalon development relationship: RO:0002296 UBERON:0001875 ! results in development of globus pallidus [Term] id: GO:0021761 name: limbic system development namespace: biological_process def: "The progression of the limbic system over time from its initial formation until its mature state. The limbic system is a collection of structures in the brain involved in emotion, motivation and emotional aspects of memory." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0878937420] is_a: GO:0048731 ! system development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0000349 ! results in development of limbic system relationship: BFO:0000050 GO:0030900 ! part of forebrain development relationship: RO:0002296 UBERON:0000349 ! results in development of limbic system [Term] id: GO:0021762 name: substantia nigra development namespace: biological_process def: "The progression of the substantia nigra over time from its initial formation until its mature state. The substantia nigra is the layer of gray substance that separates the posterior parts of the cerebral peduncles (tegmentum mesencephali) from the anterior parts; it normally includes a posterior compact part with many pigmented cells (pars compacta) and an anterior reticular part whose cells contain little pigment (pars reticularis)." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343, ISBN:0878937420] is_a: GO:0048857 ! neural nucleus development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0002038 ! results in development of substantia nigra relationship: BFO:0000050 GO:0030901 ! part of midbrain development relationship: RO:0002296 UBERON:0002038 ! results in development of substantia nigra [Term] id: GO:0021763 name: subthalamic nucleus development namespace: biological_process def: "The progression of the subthalamic nucleus over time from its initial formation until its mature state. The subthalamic nucleus is the lens-shaped nucleus located in the ventral part of the subthalamus on the inner aspect of the internal capsule that is concerned with the integration of somatic motor function." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0878937420] synonym: "corpus luysi development" RELATED [] is_a: GO:0048857 ! neural nucleus development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0001906 ! results in development of subthalamic nucleus relationship: BFO:0000050 GO:0021539 ! part of subthalamus development relationship: RO:0002296 UBERON:0001906 ! results in development of subthalamic nucleus [Term] id: GO:0021764 name: amygdala development namespace: biological_process def: "The progression of the amygdala over time from its initial formation until its mature state. The amygdala is an almond-shaped set of neurons in the medial temporal lobe of the brain that play a key role in processing emotions such as fear and pleasure." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0878937420] is_a: GO:0048856 ! anatomical structure development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0001876 ! results in development of amygdala relationship: BFO:0000050 GO:0021761 ! part of limbic system development relationship: RO:0002162 NCBITaxon:89593 ! in taxon Craniata relationship: RO:0002296 UBERON:0001876 ! results in development of amygdala [Term] id: GO:0021766 name: hippocampus development namespace: biological_process def: "The progression of the hippocampus over time from its initial formation until its mature state." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0878937420, UBERON:0002421] synonym: "hippocampal formation development" EXACT [ABA:HPF] is_a: GO:0048856 ! anatomical structure development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0002421 ! results in development of hippocampal formation relationship: BFO:0000050 GO:0021543 ! part of pallium development relationship: BFO:0000050 GO:0021761 ! part of limbic system development relationship: RO:0002296 UBERON:0002421 ! results in development of hippocampal formation [Term] id: GO:0021767 name: mammillary body development namespace: biological_process def: "The progression of the mammillary body over time from its initial formation until its mature state. The mammillary body is a protrusion at the posterior end of the hypothalamus that contains hypothalamic nuclei." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0878937420] is_a: GO:0048856 ! anatomical structure development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0002206 ! results in development of mammillary body relationship: BFO:0000050 GO:0021536 ! part of diencephalon development relationship: BFO:0000050 GO:0021761 ! part of limbic system development relationship: RO:0002296 UBERON:0002206 ! results in development of mammillary body [Term] id: GO:0021768 name: nucleus accumbens development namespace: biological_process def: "The progression of the nucleus accumbens over time from its initial formation until its mature state. The nucleus accumbens is a collection of pleomorphic cells in the caudal part of the anterior horn of the lateral ventricle, in the region of the olfactory tubercle, lying between the head of the caudate nucleus and the anterior perforated substance. It is part of the ventral striatum, a composite structure considered part of the basal ganglia." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0878937420] synonym: "accumbens nucleus development" EXACT [GOC:dgh] synonym: "ventral striatum development" BROAD [] is_a: GO:0048857 ! neural nucleus development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0001882 ! results in development of nucleus accumbens relationship: BFO:0000050 GO:0021756 ! part of striatum development relationship: BFO:0000050 GO:0021761 ! part of limbic system development relationship: RO:0002296 UBERON:0001882 ! results in development of nucleus accumbens [Term] id: GO:0021771 name: lateral geniculate nucleus development namespace: biological_process def: "The progression of the lateral geniculate nucleus over time from its initial formation until its mature state. The lateral geniculate nucleus is the primary processor of visual information received from the retina." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0878937420] synonym: "LGN development" EXACT [GOC:dgh] is_a: GO:0048857 ! neural nucleus development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0001926 ! results in development of lateral geniculate body relationship: BFO:0000050 GO:0021794 ! part of thalamus development relationship: RO:0002296 UBERON:0001926 ! results in development of lateral geniculate body [Term] id: GO:0021772 name: olfactory bulb development namespace: biological_process def: "The progression of the olfactory bulb over time from its initial formation until its mature state. The olfactory bulb coordinates neuronal signaling involved in the perception of smell. It receives input from the sensory neurons and outputs to the olfactory cortex." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0878937420] is_a: GO:0048856 ! anatomical structure development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0002264 ! results in development of olfactory bulb relationship: BFO:0000050 GO:0021988 ! part of olfactory lobe development relationship: RO:0002296 UBERON:0002264 ! results in development of olfactory bulb [Term] id: GO:0021773 name: striatal medium spiny neuron differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a medium spiny neuron residing in the striatum." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0878937420] synonym: "medium-sized spiny neuron differentiation" EXACT [PMID:25804741] synonym: "striatal MSN differentiation" EXACT [PMID:25804741] is_a: GO:0021879 ! forebrain neuron differentiation is_a: GO:0097154 ! GABAergic neuron differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:1001474 ! results in acquisition of features of medium spiny neuron relationship: BFO:0000050 GO:0021756 ! part of striatum development relationship: RO:0002315 CL:1001474 ! results in acquisition of features of medium spiny neuron [Term] id: GO:0021782 name: glial cell development namespace: biological_process def: "The process aimed at the progression of a glial cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid] is_a: GO:0048468 ! cell development intersection_of: GO:0032502 ! developmental process intersection_of: RO:0002296 CL:0000125 ! results in development of glial cell relationship: BFO:0000050 GO:0010001 ! part of glial cell differentiation relationship: RO:0002296 CL:0000125 ! results in development of glial cell [Term] id: GO:0021783 name: preganglionic parasympathetic fiber development namespace: biological_process def: "The process whose specific outcome is the progression of a preganglionic parasympathetic fiber over time, from its formation to the mature structure. A preganglionic parasympathetic fiber is a cholinergic axonal fiber projecting from the CNS to a parasympathetic ganglion." [GO_REF:0000021, GOC:cjm, GOC:cls, GOC:dgh, GOC:dph, GOC:jid] is_a: GO:0048731 ! system development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0011930 ! results in development of preganglionic parasympathetic fiber relationship: BFO:0000050 GO:0007417 ! part of central nervous system development relationship: BFO:0000050 GO:0048486 ! part of parasympathetic nervous system development relationship: RO:0002296 UBERON:0011930 ! results in development of preganglionic parasympathetic fiber [Term] id: GO:0021794 name: thalamus development namespace: biological_process def: "The process in which the thalamus changes over time, from its initial formation to its mature state." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid] is_a: GO:0048856 ! anatomical structure development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0001897 ! results in development of dorsal plus ventral thalamus relationship: BFO:0000050 GO:0021536 ! part of diencephalon development relationship: RO:0002296 UBERON:0001897 ! results in development of dorsal plus ventral thalamus [Term] id: GO:0021795 name: cerebral cortex cell migration namespace: biological_process def: "The orderly movement of cells from one site to another in the cerebral cortex." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid] is_a: GO:0022029 ! telencephalon cell migration relationship: BFO:0000050 GO:0021987 ! part of cerebral cortex development [Term] id: GO:0021799 name: cerebral cortex radially oriented cell migration namespace: biological_process def: "The migration of cells in the developing cerebral cortex in which cells move from the ventricular and/or subventricular zone toward the surface of the brain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:12626695] is_a: GO:0021795 ! cerebral cortex cell migration [Term] id: GO:0021801 name: cerebral cortex radial glia-guided migration namespace: biological_process def: "The radial migration of neuronal or glial precursor cells along radial glial cells during the development of the cerebral cortex." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:12626695] synonym: "cerebral cortex radial glia guided migration" EXACT [] synonym: "cerebral cortex radial glia-dependent cell migration" EXACT [] synonym: "glial-guided locomotion" RELATED [PMID:12626695] is_a: GO:0021799 ! cerebral cortex radially oriented cell migration is_a: GO:0022030 ! telencephalon glial cell migration [Term] id: GO:0021814 name: cell motility involved in cerebral cortex radial glia guided migration namespace: biological_process def: "The movement of a cell along the process of a radial glial cell involved in cerebral cortex glial-mediated radial migration." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:12626695] synonym: "cell locomotion involved in cerebral cortex glial-mediated radial migration" EXACT [GOC:dph] synonym: "cell locomotion involved in cerebral cortex radial glia guided migration" RELATED [GOC:dph] is_a: GO:0048870 ! cell motility intersection_of: GO:0048870 ! cell motility intersection_of: BFO:0000050 GO:0021801 ! part of cerebral cortex radial glia-guided migration relationship: BFO:0000050 GO:0021801 ! part of cerebral cortex radial glia-guided migration [Term] id: GO:0021815 name: modulation of microtubule cytoskeleton involved in cerebral cortex radial glia guided migration namespace: biological_process def: "Rearrangements of the microtubule cytoskeleton that contribute to the movement of cells along radial glial cells as a component of the process of cerebral cortex glial-mediated radial migration." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:12626695] synonym: "modulation of microtubule cytoskeleton involved in cerebral cortex glial-mediated radial migration" EXACT [GOC:dph] is_a: GO:0000226 ! microtubule cytoskeleton organization intersection_of: GO:0000226 ! microtubule cytoskeleton organization intersection_of: BFO:0000050 GO:0021801 ! part of cerebral cortex radial glia-guided migration relationship: BFO:0000050 GO:0021814 ! part of cell motility involved in cerebral cortex radial glia guided migration [Term] id: GO:0021819 name: layer formation in cerebral cortex namespace: biological_process def: "The detachment of cells from radial glial fibers at the appropriate time when they cease to migrate and form distinct layer in the cerebral cortex." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:12626695] synonym: "cerebral cortex lamination" RELATED [PMID:12626695] is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis relationship: BFO:0000050 GO:0021801 ! part of cerebral cortex radial glia-guided migration [Term] id: GO:0021822 name: negative regulation of cell motility involved in cerebral cortex radial glia guided migration namespace: biological_process def: "The intracellular signaling pathway that results in the cessation of cell movement involved in lamination of the cerebral cortex." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:tb, PMID:12626695] synonym: "down regulation of cell locomotion involved in cerebral cortex glial-mediated radial cell migration" EXACT [] synonym: "down-regulation of cell locomotion involved in cerebral cortex glial-mediated radial cell migration" EXACT [] synonym: "downregulation of cell locomotion involved in cerebral cortex glial-mediated radial cell migration" EXACT [] synonym: "inhibition of cell locomotion involved in cerebral cortex glial-mediated radial cell migration" NARROW [] synonym: "negative regulation of cell locomotion involved in cerebral cortex glial-mediated radial migration" EXACT [GOC:dph] synonym: "negative regulation of cell locomotion involved in cerebral cortex radial glia guided migration" RELATED [GOC:dph, GOC:tb] is_a: GO:1903976 ! negative regulation of glial cell migration intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0021814 ! negatively regulates cell motility involved in cerebral cortex radial glia guided migration relationship: BFO:0000050 GO:0021819 ! part of layer formation in cerebral cortex relationship: RO:0002212 GO:0021814 ! negatively regulates cell motility involved in cerebral cortex radial glia guided migration [Term] id: GO:0021826 name: substrate-independent telencephalic tangential migration namespace: biological_process def: "The process where neuronal precursors migrate tangentially in the telencephalon, primarily guided by interactions that do not require cell-cell contact." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:12626695] is_a: GO:0022029 ! telencephalon cell migration [Term] id: GO:0021830 name: interneuron migration from the subpallium to the cortex namespace: biological_process def: "The directed movement of interneurons from the subpallium to the cortex during forebrain development." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:12626695] is_a: GO:0021843 ! substrate-independent telencephalic tangential interneuron migration [Term] id: GO:0021843 name: substrate-independent telencephalic tangential interneuron migration namespace: biological_process def: "The directional movement of tangentially migrating interneurons that are not guided by attaching to extracellular substrates." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:12626695] is_a: GO:0021826 ! substrate-independent telencephalic tangential migration [Term] id: GO:0021846 name: cell proliferation in forebrain namespace: biological_process def: "The creation of greater cell numbers in the forebrain due to cell division of progenitor cells." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid] is_a: BFO:0000003 is_a: GO:0061351 ! neural precursor cell proliferation intersection_of: GO:0008283 ! cell population proliferation intersection_of: BFO:0000066 UBERON:0001890 ! occurs in forebrain relationship: BFO:0000050 GO:0030900 ! part of forebrain development relationship: BFO:0000066 UBERON:0001890 ! occurs in forebrain [Term] id: GO:0021848 name: neuroblast division in subpallium namespace: biological_process def: "The division of neuroblasts in the subpallium area of the forebrain. The interneuron precursors that these cells give rise to include GABAergic interneurons and will migrate tangentially." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:12626695] synonym: "neuroblast division in the ventral telencephalon" EXACT [PMID:16226447] is_a: GO:0055057 ! neuroblast division intersection_of: GO:0055057 ! neuroblast division intersection_of: BFO:0000066 UBERON:0000204 ! occurs in ventral part of telencephalon relationship: BFO:0000050 GO:0022012 ! part of subpallium cell proliferation in forebrain relationship: BFO:0000066 UBERON:0000204 ! occurs in ventral part of telencephalon [Term] id: GO:0021852 name: pyramidal neuron migration to cerebral cortex namespace: biological_process def: "The migration of a pyramidal neuron precursor from the ventricular zone to the correct layer of the cerebral cortex." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:12626695, PMID:22192824] synonym: "projection neuron migration" RELATED [PMID:12626695] synonym: "pyramidal neuron migration" BROAD [] is_a: GO:0021801 ! cerebral cortex radial glia-guided migration is_a: GO:0140650 ! radial glia-guided pyramidal neuron migration intersection_of: GO:0016477 ! cell migration intersection_of: RO:0002339 UBERON:0000956 ! has target end location cerebral cortex intersection_of: RO:0002565 CL:0000598 ! results in movement of pyramidal neuron relationship: BFO:0000050 GO:0021860 ! part of pyramidal neuron development relationship: RO:0002339 UBERON:0000956 ! has target end location cerebral cortex property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/21476" xsd:anyURI [Term] id: GO:0021853 name: cerebral cortex GABAergic interneuron migration namespace: biological_process def: "The migration of GABAergic interneuron precursors from the subpallium to the cerebral cortex." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:12626695] is_a: GO:0021830 ! interneuron migration from the subpallium to the cortex is_a: GO:1904936 ! interneuron migration intersection_of: GO:0016477 ! cell migration intersection_of: RO:0002565 CL:0010011 ! results in movement of cerebral cortex GABAergic interneuron relationship: BFO:0000050 GO:0021894 ! part of cerebral cortex GABAergic interneuron development relationship: RO:0002565 CL:0010011 ! results in movement of cerebral cortex GABAergic interneuron [Term] id: GO:0021854 name: hypothalamus development namespace: biological_process def: "The progression of the hypothalamus region of the forebrain, from its initial formation to its mature state." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid] is_a: GO:0048856 ! anatomical structure development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0001898 ! results in development of hypothalamus relationship: BFO:0000050 GO:0021536 ! part of diencephalon development relationship: BFO:0000050 GO:0021761 ! part of limbic system development relationship: RO:0002296 UBERON:0001898 ! results in development of hypothalamus [Term] id: GO:0021859 name: pyramidal neuron differentiation namespace: biological_process def: "The process in which a neuroblast or one of its progeny commits to a pyramidal neuron fate, migrates from the ventricular zone to the appropriate layer in the cortex and develops into a mature neuron." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid] synonym: "projection neuron differentiation" BROAD [PMID:16226447] is_a: GO:0021953 ! central nervous system neuron differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000598 ! results in acquisition of features of pyramidal neuron relationship: RO:0002315 CL:0000598 ! results in acquisition of features of pyramidal neuron [Term] id: GO:0021860 name: pyramidal neuron development namespace: biological_process def: "The progression of a pyramidal neuron from its initial formation to its mature state." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid] synonym: "projection neuron development" BROAD [PMID:16226447] is_a: GO:0021884 ! forebrain neuron development intersection_of: GO:0032502 ! developmental process intersection_of: RO:0002296 CL:0000598 ! results in development of pyramidal neuron relationship: BFO:0000050 GO:0021859 ! part of pyramidal neuron differentiation relationship: RO:0002296 CL:0000598 ! results in development of pyramidal neuron [Term] id: GO:0021861 name: forebrain radial glial cell differentiation namespace: biological_process def: "The process in which neuroepithelial cells of the neural tube give rise to radial glial cells, specialized bipotential progenitors cells of the forebrain. Differentiation includes the processes involved in commitment of a cell to a specific fate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:16226447] synonym: "radial glial cell differentiation in forebrain" EXACT [] is_a: GO:0060019 ! radial glial cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0013000 ! results in acquisition of features of forebrain radial glial cell relationship: BFO:0000050 GO:0021872 ! part of forebrain generation of neurons relationship: RO:0002315 CL:0013000 ! results in acquisition of features of forebrain radial glial cell [Term] id: GO:0021863 name: forebrain neuroblast differentiation namespace: biological_process def: "The process in which neuroepithelial cells in the neural tube acquire specialized structural and/or functional features of basal progenitor cells, neuroblasts that lose their contacts with the ventricular surface. Differentiation includes the processes involved in commitment of a cell to a specific fate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:16226447] synonym: "abventricular progenitor cell differentiation" EXACT [PMID:16226447] synonym: "intermediate progenitor cell differentiation" EXACT [PMID:16226447] synonym: "non-surface dividing progenitor cell differentiation" EXACT [PMID:16226447] is_a: GO:0014016 ! neuroblast differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:1000042 ! results in acquisition of features of forebrain neuroblast relationship: BFO:0000050 GO:0021872 ! part of forebrain generation of neurons relationship: RO:0002315 CL:1000042 ! results in acquisition of features of forebrain neuroblast [Term] id: GO:0021870 name: Cajal-Retzius cell differentiation namespace: biological_process def: "The process in which a neuroblast acquires specialized structural and/or functional features of a Cajal-Retzius cell, one of a transient population of pioneering neurons in the cerebral cortex. These cells are slender bipolar cells of the developing marginal zone. One feature of these cells in mammals is that they express the Reelin gene." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid] is_a: GO:0021895 ! cerebral cortex neuron differentiation is_a: GO:1905962 ! glutamatergic neuron differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000695 ! results in acquisition of features of Cajal-Retzius cell relationship: RO:0002315 CL:0000695 ! results in acquisition of features of Cajal-Retzius cell [Term] id: GO:0021872 name: forebrain generation of neurons namespace: biological_process def: "The process in which nerve cells are generated in the forebrain. This includes the production of neuroblasts from and their differentiation into neurons." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid] synonym: "generation of neurons in forebrain" EXACT [] is_a: GO:0048699 ! generation of neurons relationship: BFO:0000050 GO:0030900 ! part of forebrain development [Term] id: GO:0021879 name: forebrain neuron differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a neuron that will reside in the forebrain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:16226447] is_a: GO:0021953 ! central nervous system neuron differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0012001 ! results in acquisition of features of neuron of the forebrain relationship: BFO:0000050 GO:0021872 ! part of forebrain generation of neurons relationship: RO:0002315 CL:0012001 ! results in acquisition of features of neuron of the forebrain [Term] id: GO:0021884 name: forebrain neuron development namespace: biological_process def: "The process whose specific outcome is the progression of a neuron that resides in the forebrain, from its initial commitment to its fate, to the fully functional differentiated cell." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid] is_a: GO:0021954 ! central nervous system neuron development intersection_of: GO:0048468 ! cell development intersection_of: RO:0002296 CL:0012001 ! results in development of neuron of the forebrain relationship: BFO:0000050 GO:0021879 ! part of forebrain neuron differentiation relationship: RO:0002296 CL:0012001 ! results in development of neuron of the forebrain [Term] id: GO:0021885 name: forebrain cell migration namespace: biological_process def: "The orderly movement of a cell from one site to another at least one of which is located in the forebrain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid] is_a: GO:0016477 ! cell migration relationship: BFO:0000050 GO:0030900 ! part of forebrain development [Term] id: GO:0021889 name: olfactory bulb interneuron differentiation namespace: biological_process def: "The process in which a neuroblast acquires specialized features of an interneuron residing in the olfactory bulb." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:12626695] is_a: GO:0021879 ! forebrain neuron differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:1001434 ! results in acquisition of features of olfactory bulb interneuron relationship: BFO:0000050 GO:0021772 ! part of olfactory bulb development relationship: RO:0002315 CL:1001434 ! results in acquisition of features of olfactory bulb interneuron [Term] id: GO:0021891 name: olfactory bulb interneuron development namespace: biological_process def: "The process whose specific outcome is the progression of an interneuron residing in the olfactory bulb, from its initial commitment, to the fully functional differentiated cell." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:12626695] is_a: GO:0021884 ! forebrain neuron development intersection_of: GO:0048468 ! cell development intersection_of: RO:0002296 CL:1001434 ! results in development of olfactory bulb interneuron relationship: BFO:0000050 GO:0021889 ! part of olfactory bulb interneuron differentiation relationship: RO:0002296 CL:1001434 ! results in development of olfactory bulb interneuron [Term] id: GO:0021892 name: cerebral cortex GABAergic interneuron differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a GABAergic interneuron residing in the cerebral cortex." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:12626695] is_a: GO:0021895 ! cerebral cortex neuron differentiation is_a: GO:0097154 ! GABAergic neuron differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0010011 ! results in acquisition of features of cerebral cortex GABAergic interneuron relationship: RO:0002315 CL:0010011 ! results in acquisition of features of cerebral cortex GABAergic interneuron [Term] id: GO:0021894 name: cerebral cortex GABAergic interneuron development namespace: biological_process def: "The process whose specific outcome is the progression of a cerebral cortex GABAergic interneuron over time, from initial commitment to its fate, to the fully functional differentiated cell." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:12626695] is_a: GO:0021884 ! forebrain neuron development intersection_of: GO:0032502 ! developmental process intersection_of: RO:0002296 CL:0010011 ! results in development of cerebral cortex GABAergic interneuron relationship: BFO:0000050 GO:0021892 ! part of cerebral cortex GABAergic interneuron differentiation relationship: RO:0002296 CL:0010011 ! results in development of cerebral cortex GABAergic interneuron [Term] id: GO:0021895 name: cerebral cortex neuron differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a neuron residing in the cerebral cortex." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid] is_a: GO:0021879 ! forebrain neuron differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0010012 ! results in acquisition of features of cerebral cortex neuron relationship: RO:0002162 NCBITaxon:7742 ! in taxon Vertebrata relationship: RO:0002315 CL:0010012 ! results in acquisition of features of cerebral cortex neuron [Term] id: GO:0021896 name: forebrain astrocyte differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires the specialized features of an astrocyte residing in the forebrain. An astrocyte is the most abundant type of glial cell. Astrocytes provide support for neurons and regulate the environment in which they function." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:16226447] is_a: GO:0048708 ! astrocyte differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0012000 ! results in acquisition of features of astrocyte of the forebrain relationship: BFO:0000050 GO:0030900 ! part of forebrain development relationship: RO:0002315 CL:0012000 ! results in acquisition of features of astrocyte of the forebrain [Term] id: GO:0021897 name: forebrain astrocyte development namespace: biological_process def: "The process aimed at the progression of an astrocyte that resides in the forebrain, from initial commitment of the cell to its fate, to the fully functional differentiated cell. An astrocyte is the most abundant type of glial cell. Astrocytes provide support for neurons and regulate the environment in which they function." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid] is_a: GO:0014002 ! astrocyte development intersection_of: GO:0048468 ! cell development intersection_of: RO:0002296 CL:0012000 ! results in development of astrocyte of the forebrain relationship: BFO:0000050 GO:0021896 ! part of forebrain astrocyte differentiation relationship: RO:0002296 CL:0012000 ! results in development of astrocyte of the forebrain [Term] id: GO:0021903 name: rostrocaudal neural tube patterning namespace: biological_process def: "The process in which the neural tube is divided into specific regions along the rostrocaudal axis." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:11262869] synonym: "anterior-posterior neural tube patterning" RELATED [GOC:dph] is_a: GO:0009952 ! anterior/posterior pattern specification relationship: BFO:0000050 GO:0021532 ! part of neural tube patterning [Term] id: GO:0021905 name: forebrain-midbrain boundary formation namespace: biological_process def: "The process whose specific outcome is the creation of the forebrain-midbrain boundary." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:11262869] is_a: GO:0048856 ! anatomical structure development is_a: GO:0048859 ! formation of anatomical boundary intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0005075 ! results in formation of anatomical entity forebrain-midbrain boundary relationship: BFO:0000050 GO:0021903 ! part of rostrocaudal neural tube patterning relationship: RO:0002297 UBERON:0005075 ! results in formation of anatomical entity forebrain-midbrain boundary [Term] id: GO:0021906 name: hindbrain-spinal cord boundary formation namespace: biological_process def: "The process whose specific outcome is the formation of the hindbrain-spinal cord boundary." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:11262869] is_a: GO:0048859 ! formation of anatomical boundary intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0005076 ! results in formation of anatomical entity hindbrain-spinal cord boundary relationship: BFO:0000050 GO:0021903 ! part of rostrocaudal neural tube patterning relationship: RO:0002297 UBERON:0005076 ! results in formation of anatomical entity hindbrain-spinal cord boundary [Term] id: GO:0021915 name: neural tube development namespace: biological_process def: "The process whose specific outcome is the progression of the neural tube over time, from its formation to the mature structure. The mature structure of the neural tube exists when the tube has been segmented into the forebrain, midbrain, hindbrain and spinal cord regions. In addition neural crest has budded away from the epithelium." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid] is_a: GO:0035295 ! tube development is_a: GO:0060429 ! epithelium development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0001049 ! results in development of neural tube relationship: BFO:0000050 GO:0007399 ! part of nervous system development relationship: BFO:0000050 GO:0043009 ! part of chordate embryonic development relationship: RO:0002296 UBERON:0001049 ! results in development of neural tube [Term] id: GO:0021921 name: regulation of cell proliferation in dorsal spinal cord namespace: biological_process def: "The process that modulates the frequency, rate or extent of cell proliferation in the dorsal spinal cord." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid] is_a: GO:2000177 ! regulation of neural precursor cell proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0010456 ! regulates cell proliferation in dorsal spinal cord relationship: BFO:0000050 GO:0021516 ! part of dorsal spinal cord development relationship: RO:0002211 GO:0010456 ! regulates cell proliferation in dorsal spinal cord [Term] id: GO:0021952 name: central nervous system projection neuron axonogenesis namespace: biological_process def: "Generation of a long process of a CNS neuron, that carries efferent (outgoing) action potentials from the cell body towards target cells in a different central nervous system region." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid] synonym: "central nervous system axon tract development" NARROW [GOC:dph] is_a: GO:0021955 ! central nervous system neuron axonogenesis [Term] id: GO:0021953 name: central nervous system neuron differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a neuron whose cell body resides in the central nervous system." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid] is_a: GO:0030182 ! neuron differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:2000029 ! results in acquisition of features of central nervous system neuron relationship: BFO:0000050 GO:0007417 ! part of central nervous system development relationship: RO:0002315 CL:2000029 ! results in acquisition of features of central nervous system neuron [Term] id: GO:0021954 name: central nervous system neuron development namespace: biological_process def: "The process whose specific outcome is the progression of a neuron whose cell body is located in the central nervous system, from initial commitment of the cell to a neuronal fate, to the fully functional differentiated neuron." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid] is_a: GO:0048666 ! neuron development intersection_of: GO:0048468 ! cell development intersection_of: RO:0002296 CL:2000029 ! results in development of central nervous system neuron relationship: BFO:0000050 GO:0021953 ! part of central nervous system neuron differentiation relationship: RO:0002296 CL:2000029 ! results in development of central nervous system neuron [Term] id: GO:0021955 name: central nervous system neuron axonogenesis namespace: biological_process def: "Generation of a long process from a neuron whose cell body resides in the central nervous system. The process carries efferent (outgoing) action potentials from the cell body towards target cells." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid] is_a: GO:0007409 ! axonogenesis relationship: BFO:0000050 GO:0021954 ! part of central nervous system neuron development [Term] id: GO:0021957 name: corticospinal tract morphogenesis namespace: biological_process def: "Generation of a long process of a pyramidal cell, that carries efferent (outgoing) action potentials from the cell body in cerebral cortex layer V towards target cells in the gray matter of the spinal cord. This axonal process is a member of those that make up the corticospinal tract." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:9878731] synonym: "corticospinal tract axonogenesis" EXACT [GOC:dph, PMID:9878731] synonym: "CST axonogenesis" EXACT [GOC:dph, PMID:9878731] is_a: GO:0021952 ! central nervous system projection neuron axonogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0002707 ! results in morphogenesis of corticospinal tract relationship: RO:0002298 UBERON:0002707 ! results in morphogenesis of corticospinal tract [Term] id: GO:0021961 name: posterior commissure morphogenesis namespace: biological_process def: "Generation of a long process of a CNS neuron, that carries efferent (outgoing) action potentials from the cell body in the midbrain towards target cells in the diencephalon." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid] is_a: GO:0021952 ! central nervous system projection neuron axonogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0000936 ! results in morphogenesis of posterior commissure relationship: RO:0002298 UBERON:0000936 ! results in morphogenesis of posterior commissure [Term] id: GO:0021964 name: rubrospinal tract morphogenesis namespace: biological_process def: "Generation of a long process of a CNS neuron, that carries efferent (outgoing) action potentials from the cell body in the red nucleus of the midbrain towards target cells in the spinal cord." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid] is_a: GO:0021952 ! central nervous system projection neuron axonogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0002714 ! results in morphogenesis of rubrospinal tract relationship: RO:0002298 UBERON:0002714 ! results in morphogenesis of rubrospinal tract [Term] id: GO:0021982 name: pineal gland development namespace: biological_process def: "The progression of the pineal gland over time from its initial formation until its mature state. The pineal gland is an endocrine gland that secretes melatonin and is involved in circadian rhythms." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid] synonym: "epiphysis development" EXACT [GOC:dph] is_a: GO:0048732 ! gland development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0001905 ! results in development of pineal body relationship: BFO:0000050 GO:0021536 ! part of diencephalon development relationship: BFO:0000050 GO:0035270 ! part of endocrine system development relationship: RO:0002296 UBERON:0001905 ! results in development of pineal body [Term] id: GO:0021983 name: pituitary gland development namespace: biological_process def: "The progression of the pituitary gland over time from its initial formation until its mature state. The pituitary gland is an endocrine gland that secretes hormones that regulate many other glands." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid] synonym: "hypophysis development" RELATED [GOC:dph] is_a: GO:0048732 ! gland development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0000007 ! results in development of pituitary gland relationship: BFO:0000050 GO:0021536 ! part of diencephalon development relationship: BFO:0000050 GO:0035270 ! part of endocrine system development relationship: RO:0002296 UBERON:0000007 ! results in development of pituitary gland [Term] id: GO:0021984 name: adenohypophysis development namespace: biological_process def: "The progression of the adenohypophysis over time from its initial formation until its mature state. The adenohypophysis is the anterior part of the pituitary. It secretes a variety of hormones and its function is regulated by the hypothalamus." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid] synonym: "adenophysis development" EXACT [] synonym: "anterior pituitary development" EXACT [] synonym: "anterior pituitary gland development" EXACT [] is_a: GO:0048856 ! anatomical structure development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0002196 ! results in development of adenohypophysis relationship: BFO:0000050 GO:0021983 ! part of pituitary gland development relationship: RO:0002296 UBERON:0002196 ! results in development of adenohypophysis [Term] id: GO:0021985 name: neurohypophysis development namespace: biological_process def: "The progression of the neurohypophysis over time from its initial formation until its mature state. The neurohypophysis is the part of the pituitary gland that secretes hormones involved in blood pressure regulation." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid] synonym: "neurophysis development" EXACT [] synonym: "posterior pituitary development" EXACT [] synonym: "posterior pituitary gland development" EXACT [] is_a: GO:0048732 ! gland development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0002198 ! results in development of neurohypophysis relationship: BFO:0000050 GO:0021983 ! part of pituitary gland development relationship: RO:0002296 UBERON:0002198 ! results in development of neurohypophysis [Term] id: GO:0021987 name: cerebral cortex development namespace: biological_process def: "The progression of the cerebral cortex over time from its initial formation until its mature state. The cerebral cortex is the outer layered region of the telencephalon." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid] synonym: "corticogenesis" NARROW [GOC:bf, PMID:25904839] synonym: "neocortex development" RELATED [GOC:dph] is_a: GO:0048856 ! anatomical structure development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0000956 ! results in development of cerebral cortex relationship: BFO:0000050 GO:0021543 ! part of pallium development relationship: RO:0002162 NCBITaxon:7742 ! in taxon Vertebrata relationship: RO:0002296 UBERON:0000956 ! results in development of cerebral cortex [Term] id: GO:0021988 name: olfactory lobe development namespace: biological_process def: "The progression of the olfactory lobe over time from its initial formation until its mature state. The olfactory lobe is the area of the brain that process the neural inputs for the sense of smell." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid] is_a: GO:0048856 ! anatomical structure development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0005366 ! results in development of olfactory lobe relationship: BFO:0000050 GO:0021537 ! part of telencephalon development relationship: RO:0002296 UBERON:0005366 ! results in development of olfactory lobe [Term] id: GO:0021989 name: olfactory cortex development namespace: biological_process def: "The progression of the olfactory cortex over time from its initial formation until its mature state. The olfactory cortex is involved in the perception of smell. It receives input from the olfactory bulb and is responsible for the identification of odors." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid] is_a: GO:0048856 ! anatomical structure development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0002894 ! results in development of olfactory cortex relationship: BFO:0000050 GO:0021988 ! part of olfactory lobe development relationship: RO:0002162 NCBITaxon:7742 ! in taxon Vertebrata relationship: RO:0002296 UBERON:0002894 ! results in development of olfactory cortex [Term] id: GO:0021990 name: neural plate formation namespace: biological_process def: "The formation of the flat, thickened layer of ectodermal cells known as the neural plate. The underlying dorsal mesoderm signals the ectodermal cells above it to elongate into columnar neural plate cells. The neural plate subsequently develops into the neural tube, which gives rise to the central nervous system." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0878932437, ISBN:0878932585, PMID:15806586] is_a: BFO:0000003 is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0003075 ! results in formation of anatomical entity neural plate relationship: BFO:0000050 GO:0001839 ! part of neural plate morphogenesis relationship: RO:0002297 UBERON:0003075 ! results in formation of anatomical entity neural plate [Term] id: GO:0021999 name: neural plate anterior/posterior regionalization namespace: biological_process def: "The process that regulates the coordinated growth and differentiation that establishes the non-random anterior-posterior spatial arrangement of the neural plate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid] synonym: "neural plate anterior/posterior pattern formation" RELATED [GOC:dph] is_a: GO:0009952 ! anterior/posterior pattern specification is_a: GO:0060897 ! neural plate regionalization property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0022006 name: zona limitans intrathalamica formation namespace: biological_process def: "The formation of the narrow stripe of cells that lies between the prospective dorsal and ventral thalami. This boundary contains signals that pattern the prethalamic and thalamic territories of the future mid-diencephalon." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:11425897, PMID:16452095] synonym: "zli biosynthesis" EXACT [] synonym: "zli formation" EXACT [] is_a: GO:0048859 ! formation of anatomical boundary intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0009848 ! results in formation of anatomical entity zona limitans intrathalamica relationship: BFO:0000050 GO:0021903 ! part of rostrocaudal neural tube patterning relationship: RO:0002162 NCBITaxon:89593 ! in taxon Craniata relationship: RO:0002297 UBERON:0009848 ! results in formation of anatomical entity zona limitans intrathalamica [Term] id: GO:0022008 name: neurogenesis namespace: biological_process def: "Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid] synonym: "nervous system cell generation" EXACT systematic_synonym [] synonym: "neural cell differentiation" RELATED [GOC:BHF, GOC:dph] xref: Wikipedia:Neurogenesis is_a: GO:0030154 ! cell differentiation relationship: BFO:0000050 GO:0007399 ! part of nervous system development [Term] id: GO:0022009 name: central nervous system vasculogenesis namespace: biological_process def: "The differentiation of endothelial cells from progenitor cells during blood vessel development, and the de novo formation of blood vessels and tubes in the central nervous system. The capillary endothelial cells in the brain are specialized to form the blood-brain barrier." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid] is_a: GO:0001570 ! vasculogenesis intersection_of: GO:0001570 ! vasculogenesis intersection_of: RO:0002299 UBERON:0001017 ! results in maturation of central nervous system relationship: RO:0002299 UBERON:0001017 ! results in maturation of central nervous system property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/21480" xsd:anyURI [Term] id: GO:0022010 name: central nervous system myelination namespace: biological_process def: "The process in which neuronal axons and dendrites become coated with a segmented lipid-rich sheath (myelin) to enable faster and more energetically efficient conduction of electrical impulses. The sheath is formed by the cell membranes of oligodendrocytes in the central nervous system. Adjacent myelin segments are separated by a non-myelinated stretch of axon called a node of Ranvier." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid] synonym: "myelination in central nervous system" EXACT [] is_a: GO:0032291 ! axon ensheathment in central nervous system is_a: GO:0042552 ! myelination intersection_of: GO:0042552 ! myelination intersection_of: BFO:0000066 UBERON:0001017 ! occurs in central nervous system relationship: BFO:0000050 GO:0014003 ! part of oligodendrocyte development [Term] id: GO:0022011 name: myelination in peripheral nervous system namespace: biological_process def: "The process in which neuronal axons and dendrites become coated with a segmented lipid-rich sheath (myelin) to enable faster and more energetically efficient conduction of electrical impulses. The sheath is formed by the cell membranes of Schwann cells in the peripheral nervous system. Adjacent myelin segments are separated by a non-myelinated stretch of axon called a node of Ranvier." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid] synonym: "peripheral nervous system myelination" EXACT [] is_a: GO:0032292 ! peripheral nervous system axon ensheathment is_a: GO:0042552 ! myelination intersection_of: GO:0042552 ! myelination intersection_of: BFO:0000066 UBERON:0000010 ! occurs in peripheral nervous system relationship: BFO:0000050 GO:0014044 ! part of Schwann cell development [Term] id: GO:0022012 name: subpallium cell proliferation in forebrain namespace: biological_process def: "The multiplication or reproduction of subpallium cells in the forebrain, resulting in the expansion of a cell population." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid] is_a: GO:0021846 ! cell proliferation in forebrain relationship: BFO:0000050 GO:0021544 ! part of subpallium development [Term] id: GO:0022029 name: telencephalon cell migration namespace: biological_process def: "The orderly movement of a cell from one site to another at least one of which is located in the telencephalon." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid] is_a: GO:0021885 ! forebrain cell migration intersection_of: GO:0016477 ! cell migration intersection_of: RO:0002344 UBERON:0001893 ! results in transport to from or in telencephalon relationship: BFO:0000050 GO:0021537 ! part of telencephalon development relationship: RO:0002344 UBERON:0001893 ! results in transport to from or in telencephalon [Term] id: GO:0022030 name: telencephalon glial cell migration namespace: biological_process def: "The orderly movement of glial cells through the telencephalon." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid] is_a: GO:0008347 ! glial cell migration is_a: GO:0022029 ! telencephalon cell migration intersection_of: GO:0008347 ! glial cell migration intersection_of: RO:0002344 UBERON:0001893 ! results in transport to from or in telencephalon [Term] id: GO:0022031 name: telencephalon astrocyte cell migration namespace: biological_process def: "The orderly movement of an astrocyte cell through the telencephalon." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid] is_a: GO:0022030 ! telencephalon glial cell migration is_a: GO:0043615 ! astrocyte cell migration intersection_of: GO:0043615 ! astrocyte cell migration intersection_of: RO:0002344 UBERON:0001893 ! results in transport to from or in telencephalon [Term] id: GO:0022032 name: telencephalon oligodendrocyte cell migration namespace: biological_process def: "The multiplication or reproduction of telencephalon oligodendrocyte cells, resulting in the expansion of a cell population." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid] is_a: GO:0022030 ! telencephalon glial cell migration intersection_of: GO:0016477 ! cell migration intersection_of: RO:0002344 UBERON:0001893 ! results in transport to from or in telencephalon intersection_of: RO:0004009 CL:0000128 ! has primary input oligodendrocyte relationship: RO:0004009 CL:0000128 ! has primary input oligodendrocyte [Term] id: GO:0022033 name: telencephalon microglial cell migration namespace: biological_process def: "The orderly movement of microglial cells through the telencephalon." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid] is_a: GO:0022030 ! telencephalon glial cell migration intersection_of: GO:0016477 ! cell migration intersection_of: RO:0002344 UBERON:0001893 ! results in transport to from or in telencephalon intersection_of: RO:0004009 CL:0000129 ! has primary input microglial cell relationship: RO:0004009 CL:0000129 ! has primary input microglial cell [Term] id: GO:0022035 name: rhombomere cell migration namespace: biological_process def: "The movement of a cell within a rhombomere. This process is known to occur as an early step in the generation of anatomical structure from a rhombomere." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:15629700] is_a: GO:0021535 ! cell migration in hindbrain intersection_of: GO:0016477 ! cell migration intersection_of: RO:0002344 UBERON:0001892 ! results in transport to from or in rhombomere relationship: BFO:0000050 GO:0021546 ! part of rhombomere development relationship: RO:0002344 UBERON:0001892 ! results in transport to from or in rhombomere [Term] id: GO:0022037 name: metencephalon development namespace: biological_process def: "The process whose specific outcome is the progression of the metencephalon over time, from its formation to the mature structure." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid] is_a: GO:0048856 ! anatomical structure development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0001895 ! results in development of metencephalon relationship: BFO:0000050 GO:0030902 ! part of hindbrain development relationship: RO:0002296 UBERON:0001895 ! results in development of metencephalon [Term] id: GO:0022038 name: corpus callosum development namespace: biological_process def: "The process whose specific outcome is the progression of the corpus callosum over time, from its formation to the mature structure. The corpus callosum is a thick bundle of nerve fibers comprising a commissural plate connecting the two cerebral hemispheres. It consists of contralateral axon projections that provide communication between the right and left cerebral hemispheres." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid] is_a: GO:0048856 ! anatomical structure development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0002336 ! results in development of corpus callosum relationship: BFO:0000050 GO:0021537 ! part of telencephalon development relationship: RO:0002296 UBERON:0002336 ! results in development of corpus callosum [Term] id: GO:0022402 name: cell cycle process namespace: biological_process def: "The cellular process that ensures successive accurate and complete genome replication and chromosome segregation." [GOC:isa_complete, GOC:mtg_cell_cycle] subset: gocheck_do_not_annotate subset: goslim_euk_cellular_processes_ribbon is_a: GO:0009987 ! cellular process intersection_of: GO:0009987 ! cellular process intersection_of: BFO:0000050 GO:0007049 ! part of cell cycle relationship: BFO:0000050 GO:0007049 ! part of cell cycle [Term] id: GO:0022403 name: cell cycle phase namespace: biological_process def: "One of the distinct periods or stages into which the cell cycle is divided. Each phase is characterized by the occurrence of specific biochemical and morphological events." [GOC:mtg_cell_cycle] comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). subset: gocheck_do_not_annotate is_a: GO:0044848 ! biological phase [Term] id: GO:0022404 name: molting cycle process namespace: biological_process def: "A multicellular organismal process involved in the periodic casting off and regeneration of an outer covering of cuticle, feathers, hair, horns, skin." [GOC:isa_complete] is_a: GO:0032501 ! multicellular organismal process relationship: BFO:0000050 GO:0042303 ! part of molting cycle property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0022405 name: hair cycle process namespace: biological_process def: "A multicellular organismal process involved in the cyclical phases of growth (anagen), regression (catagen), quiescence (telogen), and shedding (exogen) in the life of a hair; one of the collection or mass of filaments growing from the skin of an animal, and forming a covering for a part of the head or for any part or the whole of the body." [GOC:isa_complete] is_a: GO:0022404 ! molting cycle process relationship: BFO:0000050 GO:0042633 ! part of hair cycle [Term] id: GO:0022406 name: membrane docking namespace: biological_process def: "The initial attachment of a membrane or protein to a target membrane. Docking requires only that the proteins come close enough to interact and adhere." [GOC:isa_complete, PMID:27875684] subset: goslim_pir is_a: GO:0009987 ! cellular process [Term] id: GO:0022407 name: regulation of cell-cell adhesion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of attachment of a cell to another cell." [GOC:isa_complete] is_a: GO:0030155 ! regulation of cell adhesion intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0098609 ! regulates cell-cell adhesion relationship: RO:0002211 GO:0098609 ! regulates cell-cell adhesion [Term] id: GO:0022408 name: negative regulation of cell-cell adhesion namespace: biological_process def: "Any process that stops, prevents or reduces the rate or extent of cell adhesion to another cell." [GOC:isa_complete] synonym: "down regulation of cell-cell adhesion" EXACT [] synonym: "down-regulation of cell-cell adhesion" EXACT [] synonym: "downregulation of cell-cell adhesion" EXACT [] synonym: "inhibition of cell-cell adhesion" NARROW [] is_a: GO:0007162 ! negative regulation of cell adhesion is_a: GO:0022407 ! regulation of cell-cell adhesion intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0098609 ! negatively regulates cell-cell adhesion relationship: RO:0002212 GO:0098609 ! negatively regulates cell-cell adhesion [Term] id: GO:0022409 name: positive regulation of cell-cell adhesion namespace: biological_process def: "Any process that activates or increases the rate or extent of cell adhesion to another cell." [GOC:isa_complete] synonym: "activation of cell-cell adhesion" NARROW [] synonym: "stimulation of cell-cell adhesion" NARROW [] synonym: "up regulation of cell-cell adhesion" EXACT [] synonym: "up-regulation of cell-cell adhesion" EXACT [] synonym: "upregulation of cell-cell adhesion" EXACT [] is_a: GO:0022407 ! regulation of cell-cell adhesion is_a: GO:0045785 ! positive regulation of cell adhesion intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0098609 ! positively regulates cell-cell adhesion relationship: RO:0002213 GO:0098609 ! positively regulates cell-cell adhesion [Term] id: GO:0022411 name: cellular component disassembly namespace: biological_process def: "A cellular process that results in the breakdown of a cellular component." [GOC:isa_complete] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_annotate subset: goslim_pir synonym: "cell structure disassembly" EXACT [] synonym: "cellular component disassembly at cellular level" EXACT [] is_a: GO:0016043 ! cellular component organization intersection_of: GO:0009987 ! cellular process intersection_of: RO:0002590 GO:0005575 ! results in disassembly of cellular_component disjoint_from: GO:0022607 ! cellular component assembly relationship: RO:0002590 GO:0005575 ! results in disassembly of cellular_component property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/27189" xsd:anyURI [Term] id: GO:0022412 name: cellular process involved in reproduction in multicellular organism namespace: biological_process def: "A process, occurring at the cellular level, that is involved in the reproductive function of a multicellular organism." [GOC:isa_complete] synonym: "reproductive cellular process in multicellular organism" EXACT [] is_a: GO:0009987 ! cellular process is_a: GO:0048609 ! multicellular organismal reproductive process intersection_of: GO:0009987 ! cellular process intersection_of: GO:0048609 ! multicellular organismal reproductive process [Term] id: GO:0022413 name: reproductive process in single-celled organism namespace: biological_process def: "A process, occurring at the cellular level, that is involved in the reproductive function of a single-celled organism." [GOC:isa_complete] subset: gocheck_do_not_annotate is_a: GO:0022414 ! reproductive process property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/27054" xsd:anyURI [Term] id: GO:0022414 name: reproductive process namespace: biological_process def: "A biological process that directly contributes to the process of producing new individuals by one or two organisms. The new individuals inherit some proportion of their genetic material from the parent or parents." [GOC:dph, GOC:isa_complete] subset: gocheck_do_not_annotate subset: goslim_agr subset: goslim_chembl subset: goslim_flybase_ribbon subset: goslim_generic subset: goslim_pir subset: goslim_plant subset: goslim_plant_ribbon synonym: "single organism reproductive process" RELATED [] xref: Wikipedia:Reproduction is_a: GO:0008150 ! biological_process disjoint_from: GO:0044848 ! biological phase property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/27054" xsd:anyURI creation_date: 2012-09-19T15:56:06Z [Term] id: GO:0022600 name: digestive system process namespace: biological_process def: "A physical, chemical, or biochemical process carried out by living organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism." [GOC:isa_complete, GOC:jid, GOC:mtg_cardio] subset: goslim_generic is_a: GO:0003008 ! system process intersection_of: GO:0003008 ! system process intersection_of: BFO:0000050 GO:0007586 ! part of digestion relationship: BFO:0000050 GO:0007586 ! part of digestion property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0022602 name: ovulation cycle process namespace: biological_process def: "A process involved in the sexual cycle seen in females, often with physiologic changes in the endometrium that recur at regular intervals during the reproductive years." [GOC:isa_complete] synonym: "estrous cycle process" RELATED [] synonym: "menstrual cycle process" RELATED [] is_a: GO:0022414 ! reproductive process is_a: GO:0048511 ! rhythmic process relationship: BFO:0000050 GO:0042698 ! part of ovulation cycle relationship: RO:0002162 NCBITaxon:33208 ! in taxon Metazoa [Term] id: GO:0022603 name: regulation of anatomical structure morphogenesis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of anatomical structure morphogenesis." [GOC:mah] synonym: "regulation of morphogenesis" EXACT [] is_a: GO:0050793 ! regulation of developmental process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0009653 ! regulates anatomical structure morphogenesis relationship: RO:0002211 GO:0009653 ! regulates anatomical structure morphogenesis [Term] id: GO:0022604 name: regulation of cell morphogenesis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cell morphogenesis. Cell morphogenesis is the developmental process in which the shape of a cell is generated and organized." [GOC:isa_complete] synonym: "negative regulation of cell shape and cell size" RELATED [GOC:dph, GOC:tb] synonym: "positive regulation of cell shape and cell size" RELATED [GOC:dph, GOC:tb] synonym: "regulation of cell shape and cell size" RELATED [GOC:dph, GOC:tb] is_a: GO:0022603 ! regulation of anatomical structure morphogenesis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0000902 ! regulates cell morphogenesis relationship: RO:0002211 GO:0000902 ! regulates cell morphogenesis [Term] id: GO:0022605 name: mammalian oogenesis stage namespace: biological_process def: "A reproductive process that is a step in the formation and maturation of an ovum or female gamete from a primordial female germ cell." [GOC:isa_complete, GOC:mtg_sensu] synonym: "mammalian oogenesis process" EXACT [] is_a: GO:0048609 ! multicellular organismal reproductive process relationship: BFO:0000050 GO:0048477 ! part of oogenesis [Term] id: GO:0022607 name: cellular component assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a cellular component." [GOC:isa_complete] subset: gocheck_do_not_annotate subset: goslim_chembl subset: goslim_euk_cellular_processes_ribbon subset: goslim_pir synonym: "cell structure assembly" EXACT [] synonym: "cellular component assembly at cellular level" EXACT [] is_a: GO:0016043 ! cellular component organization intersection_of: GO:0009987 ! cellular process intersection_of: RO:0002588 GO:0005575 ! results in assembly of cellular_component relationship: BFO:0000050 GO:0044085 ! part of cellular component biogenesis relationship: RO:0002588 GO:0005575 ! results in assembly of cellular_component [Term] id: GO:0022612 name: gland morphogenesis namespace: biological_process def: "The process in which the anatomical structures of a gland are generated and organized." [GOC:isa_complete] is_a: GO:0009887 ! animal organ morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0002530 ! results in morphogenesis of gland relationship: BFO:0000050 GO:0048732 ! part of gland development relationship: RO:0002298 UBERON:0002530 ! results in morphogenesis of gland [Term] id: GO:0022613 name: ribonucleoprotein complex biogenesis namespace: biological_process def: "A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a complex containing RNA and proteins. Includes the biosynthesis of the constituent RNA and protein molecules, and those macromolecular modifications that are involved in synthesis or assembly of the ribonucleoprotein complex." [GOC:isa_complete, GOC:mah] synonym: "ribonucleoprotein complex biogenesis and assembly" EXACT [GOC:mah] synonym: "RNA-protein complex biogenesis" EXACT [GOC:mah] is_a: GO:0044085 ! cellular component biogenesis [Term] id: GO:0022617 name: extracellular matrix disassembly namespace: biological_process def: "A process that results in the breakdown of the extracellular matrix." [GOC:jid] xref: Reactome:R-HSA-1474228 "Degradation of the extracellular matrix" is_a: GO:0022411 ! cellular component disassembly is_a: GO:0030198 ! extracellular matrix organization intersection_of: GO:0022411 ! cellular component disassembly intersection_of: RO:0002590 GO:0031012 ! results in disassembly of extracellular matrix relationship: RO:0002590 GO:0031012 ! results in disassembly of extracellular matrix [Term] id: GO:0022618 name: protein-RNA complex assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of proteins and RNA molecules to form a ribonucleoprotein complex." [GOC:jl] subset: goslim_chembl synonym: "ribonucleoprotein complex assembly" EXACT [] synonym: "RNA-protein complex assembly" EXACT [] synonym: "RNP complex assembly" EXACT [] is_a: GO:0065003 ! protein-containing complex assembly is_a: GO:0071826 ! protein-RNA complex organization intersection_of: GO:0022607 ! cellular component assembly intersection_of: RO:0002588 GO:1990904 ! results in assembly of ribonucleoprotein complex relationship: BFO:0000050 GO:0022613 ! part of ribonucleoprotein complex biogenesis relationship: RO:0002588 GO:1990904 ! results in assembly of ribonucleoprotein complex [Term] id: GO:0022626 name: cytosolic ribosome namespace: cellular_component def: "A ribosome located in the cytosol." [GOC:mtg_sensu] synonym: "70S ribosome" NARROW [] synonym: "80S ribosome" NARROW [] is_a: GO:0005840 ! ribosome intersection_of: GO:0005840 ! ribosome intersection_of: BFO:0000050 GO:0005829 ! part of cytosol relationship: BFO:0000050 GO:0005829 ! part of cytosol [Term] id: GO:0022803 name: passive transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of a single solute from one side of a membrane to the other by a mechanism involving conformational change, either by facilitated diffusion or in a membrane potential dependent process if the solute is charged." [GOC:mtg_transport, ISBN:0815340729] synonym: "facilitated diffusion" RELATED [] synonym: "porters" BROAD [] synonym: "uniporter activity z" NARROW [] xref: Wikipedia:Facilitated_diffusion is_a: GO:0022857 ! transmembrane transporter activity [Term] id: GO:0022804 name: active transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of a specific substance or related group of substances from one side of a membrane to the other, up the solute's concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction." [GOC:mtg_transport, ISBN:0815340729] synonym: "active carrier activity" EXACT [] synonym: "carrier activity" EXACT [] synonym: "permease activity" EXACT [] synonym: "pump activity" EXACT [] is_a: GO:0022857 ! transmembrane transporter activity [Term] id: GO:0022824 name: transmitter-gated monoatomic ion channel activity namespace: molecular_function def: "Enables the transmembrane transfer of an ion by a channel that opens when a specific neurotransmitter has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729] synonym: "ionotropic neurotransmitter receptor activity" NARROW [GOC:bf, GOC:sart] synonym: "transmitter-gated ion channel activity" BROAD [] is_a: GO:0005230 ! extracellular ligand-gated monoatomic ion channel activity is_a: GO:0022835 ! transmitter-gated channel activity [Term] id: GO:0022832 name: voltage-gated channel activity namespace: molecular_function def: "Enables the transmembrane transfer of a solute by a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:mtg_transport, ISBN:0815340729] is_a: GO:0022836 ! gated channel activity [Term] id: GO:0022834 name: ligand-gated channel activity namespace: molecular_function def: "Enables the transmembrane transfer of a solute by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729] is_a: GO:0022836 ! gated channel activity intersection_of: GO:0022836 ! gated channel activity intersection_of: RO:0012001 CHEBI:24431 ! has small molecule activator relationship: RO:0012001 CHEBI:24431 ! has small molecule activator [Term] id: GO:0022835 name: transmitter-gated channel activity namespace: molecular_function def: "Enables the transmembrane transfer of a solute by a channel that opens when a specific neurotransmitter has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729] synonym: "extracellular substance gated channel activity" EXACT [] synonym: "neurotransmitter-gated channel activity" EXACT [] is_a: GO:0022834 ! ligand-gated channel activity is_a: GO:0030594 ! neurotransmitter receptor activity [Term] id: GO:0022836 name: gated channel activity namespace: molecular_function def: "Enables the transmembrane transfer of a solute by a channel that opens in response to a specific stimulus." [GOC:mtg_transport] is_a: GO:0015267 ! channel activity [Term] id: GO:0022839 name: monoatomic ion-gated channel activity namespace: molecular_function def: "Enables the transmembrane transfer of a solute by a channel that opens in response to a specific ion stimulus." [GOC:mtg_transport] synonym: "ion gated channel activity" BROAD [] synonym: "monoatomic ion gated channel activity" EXACT [] is_a: GO:0022834 ! ligand-gated channel activity intersection_of: GO:0022836 ! gated channel activity intersection_of: RO:0012001 CHEBI:24867 ! has small molecule activator relationship: RO:0012001 CHEBI:24867 ! has small molecule activator [Term] id: GO:0022843 name: voltage-gated monoatomic cation channel activity namespace: molecular_function def: "Enables the transmembrane transfer of a cation by a voltage-gated channel. A cation is a positively charged ion. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:mtg_transport, ISBN:0815340729] synonym: "voltage-gated cation channel activity" BROAD [] xref: Reactome:R-HSA-2534378 "Hv1 Mediated H+ Permeability" xref: Reactome:R-HSA-6788999 "HV1-mediated H+ transfer" is_a: GO:0005244 ! voltage-gated monoatomic ion channel activity is_a: GO:0005261 ! monoatomic cation channel activity intersection_of: GO:0022832 ! voltage-gated channel activity intersection_of: RO:0004009 CHEBI:23906 ! has primary input property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/24479" xsd:anyURI [Term] id: GO:0022848 name: acetylcholine-gated monoatomic cation-selective channel activity namespace: molecular_function def: "Selectively enables the transmembrane transfer of a cation by a channel that opens upon binding acetylcholine." [GOC:mah, PMID:2466967] synonym: "acetylcholine-activated cation-selective channel activity" EXACT [] synonym: "acetylcholine-gated cation channel activity" EXACT [] synonym: "acetylcholine-gated cation-selective channel activity" BROAD [] synonym: "ionotropic acetylcholine receptor activity" EXACT [] synonym: "nAChR" EXACT [] synonym: "nicotinergic acetylcholine receptor activity" EXACT [] synonym: "nicotinic acetylcholine-activated cation-selective channel activity" EXACT [GOC:bf] is_a: GO:0005231 ! excitatory extracellular ligand-gated monoatomic ion channel activity is_a: GO:0099094 ! ligand-gated monoatomic cation channel activity is_a: GO:1904315 ! transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential intersection_of: GO:0022834 ! ligand-gated channel activity intersection_of: RO:0004009 CHEBI:23906 ! has primary input intersection_of: RO:0012001 CHEBI:15355 ! has small molecule activator relationship: RO:0012001 CHEBI:15355 ! has small molecule activator [Term] id: GO:0022849 name: glutamate-gated calcium ion channel activity namespace: molecular_function def: "Enables the transmembrane transfer of a calcium ion by a channel that opens when glutamate has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729] is_a: GO:0004970 ! glutamate-gated receptor activity is_a: GO:0099604 ! ligand-gated calcium channel activity intersection_of: GO:0022836 ! gated channel activity intersection_of: RO:0004009 CHEBI:29108 ! has primary input intersection_of: RO:0012001 CHEBI:14321 ! has small molecule activator [Term] id: GO:0022850 name: serotonin-gated monoatomic cation channel activity namespace: molecular_function def: "Enables the transmembrane transfer of a cation by a channel that opens when serotonin has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, PMID:12867984] comment: Note that this term represents an activity and not a gene product. Consider also annotating to the molecular function term 'G protein-coupled serotonin receptor activity ; GO:0004993'. synonym: "5-hydroxytryptamine-gated receptor-channel" NARROW [] synonym: "serotonin-activated cation-selective channel activity" EXACT [] synonym: "serotonin-gated cation channel activity" NARROW [] synonym: "serotonin-gated cation-selective channel activity" BROAD [] synonym: "serotonin-gated monoatomic cation-selective channel activity" EXACT [] xref: Reactome:R-HSA-9648983 "HTR3A pentamer:5HT transports Na+,K+,Ca2+" xref: Reactome:R-HSA-975311 "HTR3 pentamers:5HT transport Na+,K+,Ca2+" is_a: GO:0022824 ! transmitter-gated monoatomic ion channel activity is_a: GO:0099094 ! ligand-gated monoatomic cation channel activity is_a: GO:0099589 ! serotonin receptor activity intersection_of: GO:0022836 ! gated channel activity intersection_of: RO:0004009 CHEBI:23906 ! has primary input intersection_of: RO:0012001 CHEBI:350546 ! has small molecule activator relationship: BFO:0000050 GO:0007210 ! part of serotonin receptor signaling pathway [Term] id: GO:0022857 name: transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729] subset: goslim_chembl subset: goslim_drosophila subset: goslim_yeast synonym: "substrate-specific transmembrane transporter activity" RELATED [] synonym: "substrate-specific transporter activity" RELATED [] synonym: "uptake permease activity" RELATED [] synonym: "uptake transmembrane transporter activity" RELATED [] xref: Reactome:R-HSA-1236947 "Egress of internalized antigen to the cytosol via sec61" xref: Reactome:R-HSA-429036 "SLC2A9 transports Fru, Glc, urate" xref: Reactome:R-HSA-434650 "MATEs mediate extrusion of xenobiotics" xref: Reactome:R-HSA-5638209 "Defective SLC2A9 does not transport Fru, Glc, urate" xref: Reactome:R-HSA-5671707 "Fe3+ dissociates from SLC22A17:LCN2:2,5DHBA" xref: Reactome:R-HSA-6784434 "An unknown carrier transports cytosolic glyoxylate to the peroxisome" xref: Reactome:R-HSA-6784436 "An unknown carrier transports mitochondrial glyoxylate to the cytosol" xref: Reactome:R-HSA-8954513 "NAASP translocates from mitochondrial matrix to cytosol" is_a: BFO:0000003 is_a: GO:0005215 ! transporter activity intersection_of: GO:0005215 ! transporter activity intersection_of: RO:0002342 GO:0016020 ! results in transport across membrane relationship: BFO:0000050 GO:0055085 ! part of transmembrane transport relationship: RO:0002342 GO:0016020 ! results in transport across membrane [Term] id: GO:0022884 name: macromolecule transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of a macromolecule from one side of a membrane to the other." [GOC:mtg_transport, ISBN:0815340729] is_a: GO:0022857 ! transmembrane transporter activity intersection_of: GO:0022857 ! transmembrane transporter activity intersection_of: RO:0004009 CHEBI:33694 ! has primary input relationship: RO:0004009 CHEBI:33694 ! has primary input [Term] id: GO:0022898 name: regulation of transmembrane transporter activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of transmembrane transporter activity." [GOC:dph, GOC:mtg_cardio, GOC:mtg_transport] subset: gocheck_obsoletion_candidate is_a: GO:0034762 ! regulation of transmembrane transport is_a: GO:0065009 ! regulation of molecular function intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0022857 ! regulates transmembrane transporter activity relationship: RO:0002211 GO:0022857 ! regulates transmembrane transporter activity [Term] id: GO:0023019 name: signal transduction involved in regulation of gene expression namespace: biological_process def: "Any process that modulates the frequency, rate or extent of gene expression as a consequence of a process in which a signal is released and/or conveyed from one location to another." [GOC:mtg_signal] synonym: "regulation of gene expression as a consequence of signal transmission" RELATED [GOC:bf] is_a: GO:0007165 ! signal transduction intersection_of: GO:0007165 ! signal transduction intersection_of: BFO:0000050 GO:0010468 ! part of regulation of gene expression relationship: BFO:0000050 GO:0010468 ! part of regulation of gene expression creation_date: 2010-02-16T09:30:50Z [Term] id: GO:0023023 name: MHC protein complex binding namespace: molecular_function def: "Binding to a major histocompatibility complex." [GOC:mtg_signal, GOC:vw] is_a: GO:0044877 ! protein-containing complex binding intersection_of: GO:0005488 ! binding intersection_of: RO:0004009 GO:0042611 ! has primary input MHC protein complex relationship: RO:0004009 GO:0042611 ! has primary input MHC protein complex creation_date: 2010-02-16T09:30:50Z [Term] id: GO:0023026 name: MHC class II protein complex binding namespace: molecular_function def: "Binding to a class II major histocompatibility complex." [GOC:mtg_signal, GOC:vw] is_a: GO:0023023 ! MHC protein complex binding intersection_of: GO:0005488 ! binding intersection_of: RO:0004009 GO:0042613 ! has primary input MHC class II protein complex relationship: RO:0004009 GO:0042613 ! has primary input MHC class II protein complex creation_date: 2010-02-16T09:30:50Z [Term] id: GO:0023029 name: MHC class Ib protein binding namespace: molecular_function def: "Binding to a major histocompatibility complex class Ib molecules." [GOC:mtg_signal, GOC:vw] is_a: GO:0042287 ! MHC protein binding creation_date: 2010-02-16T09:30:50Z [Term] id: GO:0023051 name: regulation of signaling namespace: biological_process def: "Any process that modulates the frequency, rate or extent of a signaling process." [GOC:mtg_signal] synonym: "regulation of signaling process" RELATED [GOC:bf] synonym: "regulation of signalling process" RELATED [GOC:mah] is_a: GO:0050789 ! regulation of biological process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0023052 ! regulates signaling relationship: RO:0002211 GO:0023052 ! regulates signaling creation_date: 2010-02-16T09:30:50Z [Term] id: GO:0023052 name: signaling namespace: biological_process def: "The entirety of a process in which information is transmitted within a biological system. This process begins with an active signal and ends when a cellular response has been triggered." [GOC:mtg_signal, GOC:mtg_signaling_feb11, GOC:signaling] comment: Note that a signal is any variable property or parameter that serves to convey information, and may be a physical entity such as a gene product or small molecule, a photon, or a change in state such as movement or voltage change. subset: goslim_agr subset: goslim_euk_cellular_processes_ribbon subset: goslim_flybase_ribbon subset: goslim_generic subset: goslim_mouse subset: goslim_pombe subset: goslim_prokaryote subset: goslim_prokaryote_ribbon subset: goslim_yeast synonym: "biological signaling" EXACT [] synonym: "signaling process" EXACT [] synonym: "signalling" EXACT [] synonym: "signalling process" RELATED [GOC:mah] synonym: "single organism signaling" RELATED [] is_a: GO:0050789 ! regulation of biological process disjoint_from: GO:0044848 ! biological phase creation_date: 2010-02-16T09:30:50Z [Term] id: GO:0023056 name: positive regulation of signaling namespace: biological_process def: "Any process that activates, maintains or increases the frequency, rate or extent of a signaling process." [GOC:mtg_signal] synonym: "positive regulation of signaling process" RELATED [GOC:bf] synonym: "positive regulation of signalling process" EXACT [GOC:mah] is_a: GO:0023051 ! regulation of signaling is_a: GO:0048518 ! positive regulation of biological process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0023052 ! positively regulates signaling relationship: RO:0002213 GO:0023052 ! positively regulates signaling creation_date: 2010-02-16T09:30:50Z [Term] id: GO:0023057 name: negative regulation of signaling namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of a signaling process." [GOC:mtg_signal] synonym: "negative regulation of signaling process" RELATED [GOC:bf] synonym: "negative regulation of signalling process" RELATED [GOC:mah] is_a: GO:0023051 ! regulation of signaling is_a: GO:0048519 ! negative regulation of biological process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0023052 ! negatively regulates signaling relationship: RO:0002212 GO:0023052 ! negatively regulates signaling creation_date: 2010-02-16T09:30:50Z [Term] id: GO:0023061 name: signal release namespace: biological_process def: "The process in which a signal is secreted or discharged into the extracellular medium from a cellular source." [GOC:mtg_signal] synonym: "signal secretion" EXACT [GOC:bf] is_a: BFO:0000003 is_a: GO:0032940 ! secretion by cell intersection_of: GO:0032940 ! secretion by cell intersection_of: BFO:0000050 GO:0007267 ! part of cell-cell signaling relationship: BFO:0000050 GO:0007267 ! part of cell-cell signaling creation_date: 2010-02-16T09:30:50Z [Term] id: GO:0030001 name: metal ion transport namespace: biological_process def: "The directed movement of metal ions, any metal ion with an electric charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] synonym: "divalent metal ion export" NARROW [] synonym: "divalent metal ion transport" NARROW [] synonym: "heavy metal ion transport" NARROW [] synonym: "metal ion export" NARROW [] is_a: GO:0006812 ! monoatomic cation transport intersection_of: GO:0006810 ! transport intersection_of: RO:0004009 CHEBI:25213 ! has primary input relationship: RO:0004009 CHEBI:25213 ! has primary input property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/23033" xsd:anyURI creation_date: 2009-07-31T01:07:46Z [Term] id: GO:0030003 name: intracellular monoatomic cation homeostasis namespace: biological_process def: "A homeostatic process involved in the maintenance of a steady state level of monoatomic cations within a cell. Monatomic cations (also called simple cations) are cations consisting of exactly one atom." [GOC:ceb, GOC:mah] synonym: "cellular cation homeostasis" BROAD [] synonym: "cellular monoatomic cation homeostasis" EXACT [] is_a: GO:0006873 ! intracellular monoatomic ion homeostasis is_a: GO:0055080 ! monoatomic cation homeostasis intersection_of: GO:0019725 ! cellular homeostasis intersection_of: RO:0002332 CHEBI:23906 ! regulates levels of property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/24455" xsd:anyURI [Term] id: GO:0030007 name: intracellular potassium ion homeostasis namespace: biological_process def: "A homeostatic process involved in the maintenance of a steady state level of potassium ions within a cell." [GOC:mah] synonym: "cellular potassium ion homeostasis" EXACT [] is_a: GO:0030003 ! intracellular monoatomic cation homeostasis is_a: GO:0055075 ! potassium ion homeostasis intersection_of: GO:0055082 ! intracellular chemical homeostasis intersection_of: RO:0002332 CHEBI:29103 ! regulates levels of [Term] id: GO:0030010 name: establishment of cell polarity namespace: biological_process def: "The specification and formation of anisotropic intracellular organization or cell growth patterns." [GOC:mah] synonym: "bud site selection/establishment of cell polarity" NARROW [] synonym: "cell polarization" EXACT [] is_a: GO:0007163 ! establishment or maintenance of cell polarity [Term] id: GO:0030016 name: myofibril namespace: cellular_component def: "The contractile element of skeletal and cardiac muscle; a long, highly organized bundle of actin, myosin, and other proteins that contracts by a sliding filament mechanism." [ISBN:0815316194] xref: Wikipedia:Myofibril is_a: GO:0043292 ! contractile muscle fiber intersection_of: GO:0043292 ! contractile muscle fiber intersection_of: BFO:0000050 CL:0000737 ! part of striated muscle cell relationship: BFO:0000050 CL:0000737 ! part of striated muscle cell property_value: skos:prefLabel "myofibril" xsd:string [Term] id: GO:0030017 name: sarcomere namespace: cellular_component def: "The repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs." [ISBN:0815316194] xref: Wikipedia:Sarcomere is_a: GO:0110165 ! cellular anatomical structure relationship: BFO:0000050 GO:0030016 ! part of myofibril property_value: skos:prefLabel "sarcomere" xsd:string [Term] id: GO:0030029 name: actin filament-based process namespace: biological_process def: "Any cellular process that depends upon or alters the actin cytoskeleton, that part of the cytoskeleton comprising actin filaments and their associated proteins." [GOC:mah] synonym: "microfilament-based process" RELATED [] is_a: GO:0009987 ! cellular process intersection_of: GO:0009987 ! cellular process intersection_of: RO:0002608 GO:0005884 ! process has causal agent actin filament relationship: RO:0002608 GO:0005884 ! process has causal agent actin filament [Term] id: GO:0030030 name: cell projection organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a prolongation or process extending from a cell, e.g. a flagellum or axon." [GOC:jl, GOC:mah, PMID:16318917] subset: goslim_prokaryote synonym: "cell projection organisation" EXACT [] synonym: "cell projection organization and biogenesis" RELATED [GOC:mah] synonym: "cell surface structure organization and biogenesis" RELATED [GOC:mah] is_a: GO:0016043 ! cellular component organization intersection_of: GO:0016043 ! cellular component organization intersection_of: RO:0002592 GO:0042995 ! results in organization of cell projection relationship: RO:0002592 GO:0042995 ! results in organization of cell projection property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/26279" xsd:anyURI [Term] id: GO:0030031 name: cell projection assembly namespace: biological_process def: "Formation of a prolongation or process extending from a cell, e.g. a flagellum or axon." [GOC:jl, GOC:mah, PMID:18391171] synonym: "cell projection biogenesis" RELATED [GOC:mah] synonym: "formation of a cell surface projection" EXACT [] is_a: GO:0022607 ! cellular component assembly is_a: GO:0030030 ! cell projection organization intersection_of: GO:0022607 ! cellular component assembly intersection_of: RO:0002588 GO:0042995 ! results in assembly of cell projection relationship: RO:0002588 GO:0042995 ! results in assembly of cell projection [Term] id: GO:0030033 name: microvillus assembly namespace: biological_process def: "Formation of a microvillus, a thin cylindrical membrane-covered projection on the surface of a cell." [GOC:mah, ISBN:0815316194] synonym: "microvillus biogenesis" RELATED [GOC:mah] is_a: GO:0032528 ! microvillus organization is_a: GO:0120031 ! plasma membrane bounded cell projection assembly intersection_of: GO:0022607 ! cellular component assembly intersection_of: RO:0002588 GO:0005902 ! results in assembly of microvillus relationship: RO:0002588 GO:0005902 ! results in assembly of microvillus [Term] id: GO:0030036 name: actin cytoskeleton organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins." [GOC:dph, GOC:jl, GOC:mah] subset: goslim_pombe synonym: "actin cytoskeleton organisation" EXACT [] synonym: "actin cytoskeleton organization and biogenesis" RELATED [GOC:mah] synonym: "actin modulating activity" RELATED [] is_a: GO:0007010 ! cytoskeleton organization is_a: GO:0030029 ! actin filament-based process intersection_of: GO:0016043 ! cellular component organization intersection_of: RO:0002592 GO:0015629 ! results in organization of actin cytoskeleton relationship: RO:0002592 GO:0015629 ! results in organization of actin cytoskeleton property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/23114" xsd:anyURI [Term] id: GO:0030048 name: actin filament-based movement namespace: biological_process def: "Movement of organelles or other particles along actin filaments, or sliding of actin filaments past each other, mediated by motor proteins." [GOC:BHF, GOC:mah] is_a: GO:0030029 ! actin filament-based process property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/19809" xsd:anyURI [Term] id: GO:0030050 name: vesicle transport along actin filament namespace: biological_process def: "Movement of a vesicle along an actin filament, mediated by motor proteins." [GOC:mah] is_a: GO:0030048 ! actin filament-based movement is_a: GO:0099515 ! actin filament-based transport is_a: GO:0099518 ! vesicle cytoskeletal trafficking intersection_of: GO:0046907 ! intracellular transport intersection_of: RO:0002341 GO:0005884 ! results in transport along actin filament intersection_of: RO:0004009 GO:0031982 ! has primary input vesicle [Term] id: GO:0030054 name: cell junction namespace: cellular_component def: "A cellular component that forms a specialized region of connection between two or more cells, or between a cell and the extracellular matrix, or between two membrane-bound components of a cell, such as flagella." [GOC:aruk, GOC:bc, GOC:mah, ISBN:0198506732, PMID:26820516, PMID:28096264] subset: goslim_agr subset: goslim_drosophila subset: goslim_flybase_ribbon xref: Wikipedia:Cell_junction is_a: GO:0110165 ! cellular anatomical structure property_value: RO:0002161 NCBITaxon:4751 property_value: skos:prefLabel "cell junction" xsd:string [Term] id: GO:0030055 name: cell-substrate junction namespace: cellular_component def: "A cell junction that forms a connection between a cell and the extracellular matrix." [GOC:aruk, GOC:bc, GOC:hb, GOC:mah, PMID:10419689, PMID:1643657, PMID:16805308, PMID:26923917, PMID:8314002] synonym: "cell-matrix junction" EXACT [] is_a: GO:0070161 ! anchoring junction property_value: RO:0002161 NCBITaxon:4751 [Term] id: GO:0030057 name: desmosome namespace: cellular_component def: "A cell-cell junction in which: on the cytoplasmic surface of each interacting plasma membrane is a dense plaque composed of a mixture of intracellular anchor proteins; a bundle of keratin intermediate filaments is attached to the surface of each plaque; transmembrane adhesion proteins of the cadherin family bind to the plaques and interact through their extracellular domains to hold the adjacent membranes together by a Ca2+-dependent mechanism." [GOC:mah, GOC:mtg_muscle, ISBN:0815332181] synonym: "macula adherens" EXACT [] synonym: "spot desmosome" EXACT [] xref: Wikipedia:Desmosome is_a: GO:0005911 ! cell-cell junction property_value: RO:0002161 NCBITaxon:4751 [Term] id: GO:0030070 name: insulin processing namespace: biological_process def: "The formation of mature insulin by proteolysis of the precursor preproinsulin. The signal sequence is first cleaved from preproinsulin to form proinsulin; proinsulin is then cleaved to release the C peptide, leaving the A and B chains of mature insulin linked by disulfide bridges." [ISBN:0198506732] xref: Reactome:R-HSA-264876 "Insulin processing" is_a: GO:0016486 ! peptide hormone processing is_a: GO:1901142 ! insulin metabolic process intersection_of: GO:0016485 ! protein processing intersection_of: RO:0004007 PR:000009054 ! has primary input or output preproinsulin property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:33090 property_value: RO:0002161 NCBITaxon:4751 [Term] id: GO:0030072 name: peptide hormone secretion namespace: biological_process def: "The regulated release of a peptide hormone from a cell." [GOC:mah] is_a: GO:0002790 ! peptide secretion is_a: GO:0046879 ! hormone secretion intersection_of: GO:0046903 ! secretion intersection_of: RO:0004009 CHEBI:25905 ! has primary input relationship: RO:0004009 CHEBI:25905 ! has primary input [Term] id: GO:0030073 name: insulin secretion namespace: biological_process def: "The regulated release of proinsulin from secretory granules accompanied by cleavage of proinsulin to form mature insulin. In vertebrates, insulin is secreted from B granules in the B cells of the vertebrate pancreas and from insulin-producing cells in insects." [GOC:mah, ISBN:0198506732] is_a: GO:0009306 ! protein secretion is_a: GO:0030072 ! peptide hormone secretion intersection_of: GO:0046903 ! secretion intersection_of: RO:0004009 PR:000009054 ! has primary input preproinsulin relationship: RO:0002162 NCBITaxon:6072 ! in taxon Eumetazoa relationship: RO:0004009 PR:000009054 ! has primary input preproinsulin property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/11255" xsd:anyURI [Term] id: GO:0030097 name: hemopoiesis namespace: biological_process def: "The process whose specific outcome is the progression of the myeloid and lymphoid derived organ/tissue systems of the blood and other parts of the body over time, from formation to the mature structure. The site of hemopoiesis is variable during development, but occurs primarily in bone marrow or kidney in many adult vertebrates." [GOC:dgh, ISBN:0198506732] synonym: "blood cell biosynthesis" EXACT [] synonym: "blood cell formation" EXACT [] synonym: "haemopoiesis" EXACT [] synonym: "hematopoiesis" EXACT [] xref: Wikipedia:Haematopoiesis is_a: GO:0048468 ! cell development intersection_of: GO:0032502 ! developmental process intersection_of: RO:0002296 CL:0000988 ! results in development of hematopoietic cell relationship: RO:0002162 NCBITaxon:6072 ! in taxon Eumetazoa relationship: RO:0002296 CL:0000988 ! results in development of hematopoietic cell property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/22178" xsd:anyURI [Term] id: GO:0030098 name: lymphocyte differentiation namespace: biological_process def: "The process in which a relatively unspecialized precursor cell acquires specialized features of a lymphocyte. A lymphocyte is a leukocyte commonly found in the blood and lymph that has the characteristics of a large nucleus, a neutral staining cytoplasm, and prominent heterochromatin." [CL:0000542, GOC:go_curators] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "lymphocyte cell differentiation" EXACT [] synonym: "lymphocyte development" RELATED [GOC:add] synonym: "lymphocytic blood cell differentiation" EXACT [] is_a: GO:0046649 ! lymphocyte activation is_a: GO:1903131 ! mononuclear cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000542 ! results in acquisition of features of lymphocyte relationship: RO:0002315 CL:0000542 ! results in acquisition of features of lymphocyte [Term] id: GO:0030099 name: myeloid cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized myeloid precursor cell acquires the specialized features of any cell of the myeloid leukocyte, megakaryocyte, thrombocyte, or erythrocyte lineages." [GOC:add, ISBN:0781735149] is_a: GO:0030154 ! cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000763 ! results in acquisition of features of myeloid cell relationship: BFO:0000050 GO:0030097 ! part of hemopoiesis relationship: RO:0002315 CL:0000763 ! results in acquisition of features of myeloid cell [Term] id: GO:0030100 name: regulation of endocytosis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of endocytosis." [GOC:go_curators] is_a: GO:0051128 ! regulation of cellular component organization is_a: GO:0060627 ! regulation of vesicle-mediated transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0006897 ! regulates endocytosis relationship: RO:0002211 GO:0006897 ! regulates endocytosis [Term] id: GO:0030101 name: natural killer cell activation namespace: biological_process def: "The change in morphology and behavior of a natural killer cell in response to a cytokine, chemokine, cellular ligand, or soluble factor." [GOC:mgi_curators, ISBN:0781735149] synonym: "NK cell activation" EXACT [] is_a: GO:0046649 ! lymphocyte activation intersection_of: GO:0001775 ! cell activation intersection_of: RO:0004009 CL:0000623 ! has primary input natural killer cell relationship: RO:0004009 CL:0000623 ! has primary input natural killer cell [Term] id: GO:0030103 name: vasopressin secretion namespace: biological_process def: "The regulated release of vasopressin from secretory granules into the blood." [GOC:mah] is_a: GO:0030072 ! peptide hormone secretion intersection_of: GO:0046903 ! secretion intersection_of: RO:0004009 CHEBI:9937 ! has primary input relationship: RO:0004009 CHEBI:9937 ! has primary input [Term] id: GO:0030133 name: transport vesicle namespace: cellular_component def: "Any of the vesicles of the constitutive secretory pathway, which carry cargo from the endoplasmic reticulum to the Golgi, between Golgi cisternae, from the Golgi to the ER (retrograde transport) or to destinations within or outside the cell." [GOC:mah, PMID:22160157] comment: Note that the term 'secretory vesicle' is sometimes used in this sense, but can also mean 'secretory granule ; GO:0030141'. synonym: "constitutive secretory pathway transport vesicle" EXACT [] synonym: "Golgi to vacuole transport vesicle" NARROW [] synonym: "Golgi-vacuole transport vesicle" NARROW [] synonym: "secretory vesicle" RELATED [] xref: NIF_Subcellular:sao885490876 is_a: GO:0031410 ! cytoplasmic vesicle relationship: BFO:0000050 GO:0012505 ! part of endomembrane system [Term] id: GO:0030135 name: coated vesicle namespace: cellular_component def: "Small membrane-bounded organelle formed by pinching off of a coated region of membrane. Some coats are made of clathrin, whereas others are made from other proteins." [ISBN:0815316194] subset: goslim_drosophila xref: NIF_Subcellular:sao1985096626 is_a: GO:0031410 ! cytoplasmic vesicle [Term] id: GO:0030136 name: clathrin-coated vesicle namespace: cellular_component def: "A vesicle with a coat formed of clathrin connected to the membrane via one of the clathrin adaptor complexes." [GOC:mah, PMID:11252894] xref: NIF_Subcellular:sao148845161 is_a: GO:0030135 ! coated vesicle [Term] id: GO:0030141 name: secretory granule namespace: cellular_component def: "A small subcellular vesicle, surrounded by a membrane, that is formed from the Golgi apparatus and contains a highly concentrated protein destined for secretion. Secretory granules move towards the periphery of the cell and upon stimulation, their membranes fuse with the cell membrane, and their protein load is exteriorized. Processing of the contained protein may take place in secretory granules." [GOC:mah, ISBN:0198506732] comment: Note that the term 'secretory vesicle' is sometimes used in this sense, but can also mean 'transport vesicle ; GO:0030133'. synonym: "secretory vesicle" BROAD [] is_a: GO:0099503 ! secretory vesicle relationship: BFO:0000050 GO:0012505 ! part of endomembrane system property_value: RO:0002161 NCBITaxon:4890 [Term] id: GO:0030148 name: sphingolipid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of sphingolipids, any of a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid)." [GOC:mah, ISBN:0198506732] synonym: "sphingolipid anabolism" EXACT [] synonym: "sphingolipid biosynthesis" EXACT [] synonym: "sphingolipid formation" EXACT [] synonym: "sphingolipid synthesis" EXACT [] xref: MetaCyc:PWY-5129 xref: Reactome:R-HSA-1660661 "Sphingolipid de novo biosynthesis" is_a: GO:0006665 ! sphingolipid metabolic process is_a: GO:0046467 ! membrane lipid biosynthetic process intersection_of: GO:0009058 ! biosynthetic process intersection_of: RO:0004008 CHEBI:26739 ! has primary output relationship: RO:0004008 CHEBI:26739 ! has primary output [Term] id: GO:0030149 name: sphingolipid catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of sphingolipids, any of a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid)." [GOC:mah, ISBN:0198506732] synonym: "sphingolipid breakdown" EXACT [] synonym: "sphingolipid catabolism" EXACT [] synonym: "sphingolipid degradation" EXACT [] xref: Reactome:R-HSA-9845614 "Sphingolipid catabolism" is_a: GO:0006665 ! sphingolipid metabolic process is_a: GO:0046466 ! membrane lipid catabolic process intersection_of: GO:0009056 ! catabolic process intersection_of: RO:0004009 CHEBI:26739 ! has primary input relationship: RO:0004009 CHEBI:26739 ! has primary input [Term] id: GO:0030150 name: protein import into mitochondrial matrix namespace: biological_process def: "The import of proteins across the outer and inner mitochondrial membranes into the matrix. Unfolded proteins enter the mitochondrial matrix with a chaperone protein; the information required to target the precursor protein from the cytosol to the mitochondrial matrix is contained within its N-terminal matrix-targeting sequence. Translocation of precursors to the matrix occurs at the rare sites where the outer and inner membranes are close together." [ISBN:0716731363] synonym: "mitochondrial matrix protein import" EXACT [] synonym: "mitochondrial translocation" BROAD [] synonym: "protein transport into mitochondrial matrix" EXACT [] is_a: GO:0070585 ! protein localization to mitochondrion is_a: GO:0071806 ! protein transmembrane transport is_a: GO:0072655 ! establishment of protein localization to mitochondrion intersection_of: GO:0006810 ! transport intersection_of: RO:0002338 GO:0005829 ! has target start location cytosol intersection_of: RO:0002339 GO:0005759 ! has target end location mitochondrial matrix intersection_of: RO:0002342 GO:0031966 ! results in transport across mitochondrial membrane intersection_of: RO:0004009 PR:000000001 ! has primary input protein relationship: RO:0002338 GO:0005829 ! has target start location cytosol relationship: RO:0002339 GO:0005759 ! has target end location mitochondrial matrix relationship: RO:0002342 GO:0031966 ! results in transport across mitochondrial membrane property_value: IAO:0000233 "/github.com/geneontology/go-ontology/issues/29962" xsd:anyURI [Term] id: GO:0030154 name: cell differentiation namespace: biological_process def: "The cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [ISBN:0198506732] subset: goslim_agr subset: goslim_chembl subset: goslim_drosophila subset: goslim_generic subset: goslim_mouse subset: goslim_plant subset: goslim_plant_ribbon xref: Wikipedia:Cellular_differentiation is_a: BFO:0000003 is_a: GO:0048869 ! cellular developmental process intersection_of: GO:0048869 ! cellular developmental process intersection_of: RO:0002315 CL:0000000 ! results in acquisition of features of cell relationship: RO:0002315 CL:0000000 ! results in acquisition of features of cell property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/24390" xsd:anyURI [Term] id: GO:0030155 name: regulation of cell adhesion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of attachment of a cell to another cell or to the extracellular matrix." [GOC:mah] synonym: "cell adhesion receptor regulator activity" RELATED [] is_a: GO:0050794 ! regulation of cellular process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0007155 ! regulates cell adhesion relationship: RO:0002211 GO:0007155 ! regulates cell adhesion [Term] id: GO:0030162 name: regulation of proteolysis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the hydrolysis of a peptide bond or bonds within a protein." [GOC:mah] synonym: "regulation of peptidolysis" EXACT [] is_a: GO:0051246 ! regulation of protein metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0006508 ! regulates proteolysis relationship: RO:0002211 GO:0006508 ! regulates proteolysis [Term] id: GO:0030163 name: protein catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds." [GOC:mah] comment: This term refers to the breakdown of mature proteins. For cleavage events involved in generating a mature protein from a precursor, consider instead the term 'protein maturation ; GO:0051604' and its children. subset: goslim_candida subset: goslim_drosophila subset: goslim_generic subset: goslim_pombe subset: goslim_prokaryote synonym: "cellular protein breakdown" EXACT [] synonym: "cellular protein catabolic process" EXACT [] synonym: "cellular protein catabolism" EXACT [] synonym: "cellular protein degradation" EXACT [] synonym: "multicellular organismal protein catabolic process" NARROW [] synonym: "pheromone catabolic process" RELATED [] synonym: "pheromone catabolism" RELATED [] synonym: "protein breakdown" EXACT [] synonym: "protein catabolism" EXACT [] synonym: "protein degradation" EXACT [] xref: Wikipedia:Protein_catabolism is_a: GO:0009057 ! macromolecule catabolic process is_a: GO:0019538 ! protein metabolic process intersection_of: GO:0009056 ! catabolic process intersection_of: RO:0004009 PR:000000001 ! has primary input protein relationship: RO:0004009 PR:000000001 ! has primary input protein property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/23112" xsd:anyURI [Term] id: GO:0030166 name: proteoglycan biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of proteoglycans, any glycoprotein in which the carbohydrate units are glycosaminoglycans." [PMID:35536939] synonym: "proteoglycan anabolism" EXACT [] synonym: "proteoglycan biosynthesis" EXACT [] synonym: "proteoglycan formation" EXACT [] synonym: "proteoglycan synthesis" EXACT [] is_a: GO:0006029 ! proteoglycan metabolic process is_a: GO:0009101 ! glycoprotein biosynthetic process intersection_of: GO:0009058 ! biosynthetic process intersection_of: RO:0004008 CHEBI:37396 ! has primary output relationship: RO:0004008 CHEBI:37396 ! has primary output property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/29745" xsd:anyURI [Term] id: GO:0030167 name: proteoglycan catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of proteoglycans, any glycoprotein in which the carbohydrate units are glycosaminoglycans." [PMID:35536982] synonym: "proteoglycan breakdown" EXACT [] synonym: "proteoglycan catabolism" EXACT [] synonym: "proteoglycan degradation" EXACT [] is_a: GO:0006029 ! proteoglycan metabolic process is_a: GO:0006516 ! glycoprotein catabolic process intersection_of: GO:0009056 ! catabolic process intersection_of: RO:0004009 CHEBI:37396 ! has primary input relationship: RO:0004009 CHEBI:37396 ! has primary input property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/29745" xsd:anyURI [Term] id: GO:0030168 name: platelet activation namespace: biological_process def: "A series of progressive, overlapping events triggered by exposure of the platelets to subendothelial tissue. These events include shape change, adhesiveness, aggregation, and release reactions. When carried through to completion, these events lead to the formation of a stable hemostatic plug." [PMID:27403440] synonym: "blood coagulation, platelet activation" EXACT [GOC:add, GOC:pde] xref: Reactome:R-HSA-392023 "Adrenaline signalling through Alpha-2 adrenergic receptor" xref: Reactome:R-HSA-392170 "ADP signalling through P2Y purinoceptor 12" xref: Reactome:R-HSA-418592 "ADP signalling through P2Y purinoceptor 1" xref: Reactome:R-HSA-76002 "Platelet activation, signaling and aggregation" is_a: BFO:0000003 is_a: GO:0001775 ! cell activation intersection_of: GO:0001775 ! cell activation intersection_of: RO:0004009 CL:0000233 ! has primary input platelet relationship: BFO:0000050 GO:0007596 ! part of blood coagulation relationship: RO:0004009 CL:0000233 ! has primary input platelet [Term] id: GO:0030171 name: voltage-gated proton channel activity namespace: molecular_function def: "Enables the transmembrane transfer of a proton by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [PMID:28774948] synonym: "voltage gated proton channel activity" EXACT [] synonym: "voltage-dependent proton channel activity" EXACT [] is_a: GO:0015252 ! proton channel activity is_a: GO:0022843 ! voltage-gated monoatomic cation channel activity intersection_of: GO:0022832 ! voltage-gated channel activity intersection_of: RO:0004009 CHEBI:15378 ! has primary input [Term] id: GO:0030182 name: neuron differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a neuron." [GOC:mah] is_a: GO:0030154 ! cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000540 ! results in acquisition of features of neuron relationship: BFO:0000050 GO:0048699 ! part of generation of neurons relationship: RO:0002315 CL:0000540 ! results in acquisition of features of neuron [Term] id: GO:0030183 name: B cell differentiation namespace: biological_process def: "The process in which a precursor cell type acquires the specialized features of a B cell. A B cell is a lymphocyte of B lineage with the phenotype CD19-positive and capable of B cell mediated immunity." [GO_REF:0000022, GOC:mah] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "B cell development" RELATED [GOC:add] synonym: "B lymphocyte differentiation" EXACT [] synonym: "B-cell differentiation" EXACT [] synonym: "B-lymphocyte differentiation" EXACT [] is_a: GO:0030098 ! lymphocyte differentiation is_a: GO:0042113 ! B cell activation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000236 ! results in acquisition of features of B cell relationship: RO:0002315 CL:0000236 ! results in acquisition of features of B cell [Term] id: GO:0030184 name: nitric oxide transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of nitric oxide, nitrogen monoxide, from one side of a membrane to the other." [GOC:mah] is_a: GO:0022857 ! transmembrane transporter activity intersection_of: GO:0022857 ! transmembrane transporter activity intersection_of: RO:0004009 CHEBI:16480 ! has primary input relationship: BFO:0000050 GO:0030185 ! part of nitric oxide transport relationship: RO:0004009 CHEBI:16480 ! has primary input [Term] id: GO:0030185 name: nitric oxide transport namespace: biological_process def: "The directed movement of nitric oxide, nitrogen monoxide, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah] is_a: GO:0071705 ! nitrogen compound transport intersection_of: GO:0006810 ! transport intersection_of: RO:0004009 CHEBI:16480 ! has primary input relationship: RO:0004009 CHEBI:16480 ! has primary input [Term] id: GO:0030186 name: melatonin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving melatonin (N-acetyl-5-methoxytryptamine)." [GOC:mah, ISBN:0198506732] synonym: "melatonin metabolism" EXACT [] is_a: GO:0042430 ! indole-containing compound metabolic process is_a: GO:0042445 ! hormone metabolic process is_a: GO:0043603 ! amide metabolic process intersection_of: GO:0008152 ! metabolic process intersection_of: RO:0004007 CHEBI:16796 ! has primary input or output relationship: RO:0004007 CHEBI:16796 ! has primary input or output property_value: RO:0002161 NCBITaxon:4895 [Term] id: GO:0030187 name: melatonin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of melatonin (N-acetyl-5-methoxytryptamine)." [GOC:mah, ISBN:0198506732] synonym: "melatonin anabolism" EXACT [] synonym: "melatonin biosynthesis" EXACT [] synonym: "melatonin formation" EXACT [] synonym: "melatonin synthesis" EXACT [] is_a: GO:0030186 ! melatonin metabolic process is_a: GO:0042435 ! indole-containing compound biosynthetic process is_a: GO:0042446 ! hormone biosynthetic process is_a: GO:0043604 ! amide biosynthetic process intersection_of: GO:0009058 ! biosynthetic process intersection_of: RO:0004008 CHEBI:16796 ! has primary output relationship: RO:0004008 CHEBI:16796 ! has primary output property_value: RO:0002161 NCBITaxon:4895 [Term] id: GO:0030193 name: regulation of blood coagulation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of blood coagulation." [GOC:mah] is_a: GO:0032101 ! regulation of response to external stimulus is_a: GO:0050818 ! regulation of coagulation is_a: GO:0061041 ! regulation of wound healing is_a: GO:1900046 ! regulation of hemostasis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0007596 ! regulates blood coagulation relationship: RO:0002211 GO:0007596 ! regulates blood coagulation [Term] id: GO:0030194 name: positive regulation of blood coagulation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of blood coagulation." [GOC:mah] synonym: "activation of blood coagulation" NARROW [] synonym: "stimulation of blood coagulation" NARROW [] synonym: "up regulation of blood coagulation" EXACT [] synonym: "up-regulation of blood coagulation" EXACT [] synonym: "upregulation of blood coagulation" EXACT [] is_a: GO:0030193 ! regulation of blood coagulation is_a: GO:0050820 ! positive regulation of coagulation is_a: GO:0090303 ! positive regulation of wound healing is_a: GO:1900048 ! positive regulation of hemostasis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0007596 ! positively regulates blood coagulation relationship: RO:0002213 GO:0007596 ! positively regulates blood coagulation [Term] id: GO:0030195 name: negative regulation of blood coagulation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of blood coagulation." [GOC:mah] synonym: "down regulation of blood coagulation" EXACT [] synonym: "down-regulation of blood coagulation" EXACT [] synonym: "downregulation of blood coagulation" EXACT [] synonym: "inhibition of blood coagulation" NARROW [] is_a: GO:0030193 ! regulation of blood coagulation is_a: GO:0050819 ! negative regulation of coagulation is_a: GO:0061045 ! negative regulation of wound healing is_a: GO:1900047 ! negative regulation of hemostasis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0007596 ! negatively regulates blood coagulation relationship: RO:0002212 GO:0007596 ! negatively regulates blood coagulation [Term] id: GO:0030198 name: extracellular matrix organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an extracellular matrix." [GOC:mah] subset: goslim_chembl subset: goslim_drosophila subset: goslim_generic synonym: "extracellular matrix organisation" EXACT [] synonym: "extracellular matrix organization and biogenesis" RELATED [GOC:mah] xref: Reactome:R-HSA-1474244 "Extracellular matrix organization" is_a: GO:0043062 ! extracellular structure organization is_a: GO:0045229 ! external encapsulating structure organization intersection_of: GO:0016043 ! cellular component organization intersection_of: RO:0002592 GO:0031012 ! results in organization of extracellular matrix relationship: RO:0002592 GO:0031012 ! results in organization of extracellular matrix [Term] id: GO:0030199 name: collagen fibril organization namespace: biological_process def: "Any process that determines the size and arrangement of collagen fibrils within an extracellular matrix." [GOC:mah, ISBN:0815316194] synonym: "collagen fibril organisation" EXACT [] synonym: "fibrillar collagen organization" EXACT [GOC:mah] xref: Reactome:R-HSA-1474290 "Collagen formation" xref: Reactome:R-HSA-2214320 "Anchoring fibril formation" xref: Reactome:R-HSA-2243919 "Crosslinking of collagen fibrils" is_a: GO:0030198 ! extracellular matrix organization intersection_of: GO:0016043 ! cellular component organization intersection_of: RO:0002592 GO:0098643 ! results in organization of fibrillar collagen relationship: RO:0002592 GO:0098643 ! results in organization of fibrillar collagen property_value: RO:0002161 NCBITaxon:4751 [Term] id: GO:0030202 name: heparin proteoglycan metabolic process namespace: biological_process def: "The chemical reactions and pathways involving heparin proteoglycans, which consist of a core protein linked to a heparin glycosaminoglycan. The heparin chain is composed of the repeating disaccharide unit beta-(1,4)-N-acetyl-D-glucosamine-alpha-(1,4)-hexuronic acid, the former being either sulfated or deacetylated on its amino group as well as sulfated on one of its hydroxyl groups, and the latter being e a mixture of sulfated and nonsulfated D-glucuronic and L-iduronic acids. Heparin is similar to heparan sulfate but it contains more N-sulfate and O-sulfate groups. Heparin proteoglycans are stored selectively in the secretory granules of mammalian mast cells." [PMID:22566225] synonym: "heparan sulfate metabolic process" RELATED [] synonym: "heparin metabolism" EXACT [] is_a: GO:0006029 ! proteoglycan metabolic process intersection_of: GO:0008152 ! metabolic process intersection_of: RO:0004009 CHEBI:233528 ! has primary input relationship: RO:0004009 CHEBI:233528 ! has primary input property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/28977" xsd:anyURI property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/29745" xsd:anyURI [Term] id: GO:0030203 name: glycosaminoglycan metabolic process namespace: biological_process def: "The chemical reactions and pathways involving glycosaminoglycans, any of a group of linear polysaccharides composed of repeating disaccharide units." [PMID:38500384] synonym: "glycosaminoglycan metabolism" EXACT [] xref: Reactome:R-HSA-1630316 "Glycosaminoglycan metabolism" is_a: GO:0006022 ! aminoglycan metabolic process intersection_of: GO:0008152 ! metabolic process intersection_of: RO:0004007 CHEBI:18085 ! has primary input or output relationship: RO:0004007 CHEBI:18085 ! has primary input or output property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/29745" xsd:anyURI [Term] id: GO:0030210 name: heparin proteoglycan biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of heparin proteoglycans, which consist of a core protein linked to a heparin glycosaminoglycan. The heparin chain is composed of the repeating disaccharide unit beta-(1,4)-N-acetyl-D-glucosamine-alpha-(1,4)-hexuronic acid, the former being either sulfated or deacetylated on its amino group as well as sulfated on one of its hydroxyl groups, and the latter being a mixture of sulfated and nonsulfated D-glucuronic and L-iduronic acids. Heparin is similar to heparan sulfate but it contains more N-sulfate and O-sulfate groups. Heparin chains are covalently linked to serine/threonine residues (O-linked) of the core protein via a tetrasaccharide linker sequence (xylose-galactose-galactose-glucuronate)." [PMID:22566225] synonym: "heparan sulfate biosynthetic process" RELATED [] synonym: "heparin anabolism" EXACT [] synonym: "heparin biosynthesis" EXACT [] synonym: "heparin formation" EXACT [] synonym: "heparin synthesis" EXACT [] is_a: GO:0030202 ! heparin proteoglycan metabolic process is_a: GO:0180064 ! protein O-linked glycosylation via xylose intersection_of: GO:0009058 ! biosynthetic process intersection_of: RO:0004009 CHEBI:233528 ! has primary input property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/28977" xsd:anyURI property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/29745" xsd:anyURI property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/30378" xsd:anyURI [Term] id: GO:0030211 name: heparin proteoglycan catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of heparin proteoglycans, which consist of a core protein linked to a heparin glycosaminoglycan. The heparin chain is composed of the repeating disaccharide unit beta-(1,4)-N-acetyl-D-glucosamine-alpha-(1,4)-hexuronic acid, the former being either sulfated or deacetylated on its amino group as well as sulfated on one of its hydroxyl groups and the latter being a mixture of sulfated and nonsulfated D-glucuronic and L-iduronic acids. Heparin is similar to heparan sulfate but it contains more N-sulfate and O-sulfate groups." [PMID:35536982] synonym: "heparan sulfate catabolic process" RELATED [] synonym: "heparin breakdown" EXACT [] synonym: "heparin catabolism" EXACT [] synonym: "heparin degradation" EXACT [] is_a: GO:0030167 ! proteoglycan catabolic process is_a: GO:0030202 ! heparin proteoglycan metabolic process intersection_of: GO:0009056 ! catabolic process intersection_of: RO:0004009 CHEBI:233528 ! has primary input property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/28977" xsd:anyURI property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/29745" xsd:anyURI [Term] id: GO:0030212 name: hyaluronan metabolic process namespace: biological_process def: "The chemical reactions and pathways involving hyaluronan, the naturally occurring anionic form of hyaluronic acid. Hyaluronan is a type of non-sulfated glycosaminoglycan composed of the repeating disaccharide unit beta(1,4)-D-glucuronic acid-beta(1,3)-N-acetyl-D-glucosamine." [PMID:33171800, PMID:35536932] synonym: "hyaluronan metabolism" EXACT [] xref: Reactome:R-HSA-2142845 "Hyaluronan metabolism" is_a: GO:0030203 ! glycosaminoglycan metabolic process intersection_of: GO:0008152 ! metabolic process intersection_of: RO:0004007 CHEBI:16336 ! has primary input or output relationship: RO:0004007 CHEBI:16336 ! has primary input or output property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/29745" xsd:anyURI [Term] id: GO:0030213 name: hyaluronan biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of hyaluronan, the naturally occurring anionic form of hyaluronic acid. Hyaluronan is a type of non-sulfated glycosaminoglycan composed of the repeating disaccharide unit beta(1,4)-D-glucuronic acid-beta(1,3)-N-acetyl-D-glucosamine." [PMID:33171800, PMID:35536932] synonym: "hyaluronan anabolism" EXACT [] synonym: "hyaluronan biosynthesis" EXACT [] synonym: "hyaluronan formation" EXACT [] synonym: "hyaluronan synthesis" EXACT [] xref: Reactome:R-HSA-2142850 "Hyaluronan biosynthesis and export" is_a: GO:0006024 ! glycosaminoglycan biosynthetic process is_a: GO:0030212 ! hyaluronan metabolic process intersection_of: GO:0009058 ! biosynthetic process intersection_of: RO:0004008 CHEBI:16336 ! has primary output relationship: RO:0004008 CHEBI:16336 ! has primary output property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/29745" xsd:anyURI [Term] id: GO:0030214 name: hyaluronan catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of hyaluronan, the naturally occurring anionic form of hyaluronic acid. Hyaluronan is a type of non-sulfated glycosaminoglycan composed of the repeating disaccharide unit beta(1,4)-D-glucuronic acid-beta(1,3)-N-acetyl-D-glucosamine." [PMID:33171800, PMID:35536932] synonym: "hyaluronan breakdown" EXACT [] synonym: "hyaluronan catabolism" EXACT [] synonym: "hyaluronan degradation" EXACT [] xref: MetaCyc:PWY-7645 xref: Reactome:R-HSA-2160916 "Hyaluronan uptake and degradation" is_a: GO:0006027 ! glycosaminoglycan catabolic process is_a: GO:0030212 ! hyaluronan metabolic process intersection_of: GO:0009056 ! catabolic process intersection_of: RO:0004009 CHEBI:16336 ! has primary input relationship: RO:0004009 CHEBI:16336 ! has primary input property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/27107" xsd:anyURI [Term] id: GO:0030216 name: keratinocyte differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a keratinocyte." [GOC:dph, GOC:mah, GOC:sdb_2009, GOC:tb] synonym: "keratinocyte cell differentiation" EXACT [] is_a: GO:0009913 ! epidermal cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000312 ! results in acquisition of features of keratinocyte relationship: BFO:0000050 GO:0043588 ! part of skin development relationship: RO:0002315 CL:0000312 ! results in acquisition of features of keratinocyte [Term] id: GO:0030217 name: T cell differentiation namespace: biological_process def: "The process in which a precursor cell type acquires characteristics of a more mature T-cell. A T cell is a type of lymphocyte whose definin characteristic is the expression of a T cell receptor complex." [GO_REF:0000022, GOC:jid, GOC:mah] comment: Note that the term 'thymocyte differentiation' was merged into this term because thymocytes are T cells, and thus the term was essentially redundant. Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "T cell development" RELATED [GOC:add] synonym: "T lymphocyte differentiation" EXACT [] synonym: "T-cell differentiation" EXACT [] synonym: "T-lymphocyte differentiation" EXACT [] is_a: GO:0030098 ! lymphocyte differentiation is_a: GO:0042110 ! T cell activation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000084 ! results in acquisition of features of T cell relationship: RO:0002315 CL:0000084 ! results in acquisition of features of T cell [Term] id: GO:0030218 name: erythrocyte differentiation namespace: biological_process def: "The process in which a myeloid precursor cell acquires specializes features of an erythrocyte." [GOC:mah] synonym: "erythrocyte cell differentiation" EXACT [] synonym: "erythropoiesis" EXACT [GOC:add, GOC:dph] synonym: "RBC differentiation" EXACT [CL:0000232] synonym: "red blood cell differentiation" EXACT [CL:0000232] xref: Wikipedia:Erythropoiesis is_a: GO:0030099 ! myeloid cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000232 ! results in acquisition of features of erythrocyte relationship: BFO:0000050 GO:0034101 ! part of erythrocyte homeostasis relationship: RO:0002315 CL:0000232 ! results in acquisition of features of erythrocyte [Term] id: GO:0030219 name: megakaryocyte differentiation namespace: biological_process def: "The process in which a myeloid precursor cell acquires specializes features of a megakaryocyte." [GOC:mah] synonym: "megakaryocyte cell differentiation" EXACT [] is_a: GO:0030099 ! myeloid cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000556 ! results in acquisition of features of megakaryocyte relationship: RO:0002315 CL:0000556 ! results in acquisition of features of megakaryocyte [Term] id: GO:0030220 name: platelet formation namespace: biological_process def: "The process in which platelets bud from long processes extended by megakaryocytes." [GOC:mah, ISBN:0815316194] synonym: "platelet extrusion" EXACT systematic_synonym [GOC:curators] is_a: GO:0030099 ! myeloid cell differentiation is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 CL:0000233 ! results in formation of anatomical entity platelet relationship: BFO:0000050 GO:0036344 ! part of platelet morphogenesis relationship: RO:0002297 CL:0000233 ! results in formation of anatomical entity platelet [Term] id: GO:0030221 name: basophil differentiation namespace: biological_process def: "The process in which a relatively unspecialized myeloid precursor cell acquires specialized features of a basophil cell." [GOC:jid, GOC:mah] synonym: "basophil cell differentiation" EXACT [] is_a: GO:0030851 ! granulocyte differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000767 ! results in acquisition of features of basophil relationship: RO:0002315 CL:0000767 ! results in acquisition of features of basophil [Term] id: GO:0030222 name: eosinophil differentiation namespace: biological_process def: "The process in which a relatively unspecialized myeloid precursor cell acquires the specializes features of an eosinophil." [GOC:add, GOC:mah] synonym: "eosinophil cell development" RELATED [GOC:bf] synonym: "eosinophil cell differentiation" EXACT [] synonym: "eosinophil development" RELATED [] is_a: GO:0030851 ! granulocyte differentiation is_a: GO:0048468 ! cell development intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000771 ! results in acquisition of features of eosinophil relationship: RO:0002315 CL:0000771 ! results in acquisition of features of eosinophil [Term] id: GO:0030223 name: neutrophil differentiation namespace: biological_process def: "The process in which a myeloid precursor cell acquires the specialized features of a neutrophil." [GOC:mah] synonym: "neutrophil cell differentiation" EXACT [] synonym: "neutrophil granulocyte differentiation" EXACT [GOC:yaf] synonym: "neutrophil granulocytopoiesis" EXACT [GOC:yaf] is_a: GO:0030851 ! granulocyte differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000775 ! results in acquisition of features of neutrophil relationship: RO:0002315 CL:0000775 ! results in acquisition of features of neutrophil [Term] id: GO:0030224 name: monocyte differentiation namespace: biological_process def: "The process in which a relatively unspecialized myeloid precursor cell acquires the specialized features of a monocyte." [GOC:mah] synonym: "monocyte cell differentiation" EXACT [] is_a: GO:0002573 ! myeloid leukocyte differentiation is_a: GO:1903131 ! mononuclear cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000576 ! results in acquisition of features of monocyte relationship: RO:0002315 CL:0000576 ! results in acquisition of features of monocyte [Term] id: GO:0030225 name: macrophage differentiation namespace: biological_process def: "The process in which a relatively unspecialized monocyte acquires the specialized features of a macrophage." [GOC:add, ISBN:0781735149] synonym: "macrophage cell differentiation" EXACT [] is_a: GO:0002573 ! myeloid leukocyte differentiation is_a: GO:1903131 ! mononuclear cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000235 ! results in acquisition of features of macrophage relationship: RO:0002315 CL:0000235 ! results in acquisition of features of macrophage [Term] id: GO:0030228 name: lipoprotein particle receptor activity namespace: molecular_function def: "Combining with a lipoprotein particle and delivering the lipoprotein particle into the cell via endocytosis. A lipoprotein particle, also known as a lipoprotein, is a clathrate complex consisting of a lipid enwrapped in a protein host without covalent binding in such a way that the complex has a hydrophilic outer surface consisting of all the protein and the polar ends of any phospholipids." [GOC:bf, GOC:mah, PMID:12827279] comment: This term is intended for cell surface receptors that bind and internalize a lipoprotein particle. For members of the lipoprotein receptor family that transduce a signal rather than endocytose their ligand, consider instead the terms 'signaling receptor activity ; GO:0038023' and its children, or 'reelin receptor activity ; GO:0038025'. synonym: "lipoprotein receptor activity" EXACT [GOC:dph] synonym: "plasma lipoprotein particle receptor activity" NARROW [GOC:BHF] is_a: BFO:0000003 is_a: GO:0038024 ! cargo receptor activity intersection_of: GO:0038024 ! cargo receptor activity intersection_of: RO:0004009 CHEBI:6495 ! has primary input relationship: BFO:0000051 GO:0071813 ! has part lipoprotein particle binding relationship: RO:0004009 CHEBI:6495 ! has primary input [Term] id: GO:0030239 name: myofibril assembly namespace: biological_process def: "Formation of myofibrils, the repeating units of striated muscle." [GOC:mah] is_a: GO:0010927 ! cellular component assembly involved in morphogenesis is_a: GO:0031032 ! actomyosin structure organization is_a: GO:0097435 ! supramolecular fiber organization is_a: GO:0140694 ! membraneless organelle assembly intersection_of: GO:0022607 ! cellular component assembly intersection_of: RO:0002588 GO:0030016 ! results in assembly of myofibril relationship: BFO:0000050 GO:0055002 ! part of striated muscle cell development relationship: RO:0002588 GO:0030016 ! results in assembly of myofibril [Term] id: GO:0030246 name: carbohydrate binding namespace: molecular_function def: "Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [GOC:mah] subset: goslim_agr subset: goslim_chembl subset: goslim_drosophila subset: goslim_flybase_ribbon subset: goslim_metagenomics subset: goslim_pir subset: goslim_plant subset: goslim_plant_ribbon synonym: "selectin" RELATED [] synonym: "sugar binding" EXACT [] is_a: BFO:0000003 is_a: GO:0005488 ! binding intersection_of: GO:0005488 ! binding intersection_of: RO:0004009 CHEBI:16646 ! has primary input relationship: RO:0004009 CHEBI:16646 ! has primary input [Term] id: GO:0030247 name: polysaccharide binding namespace: molecular_function def: "Binding to a polysaccharide, a polymer of many (typically more than 10) monosaccharide residues linked glycosidically." [GOC:mah] synonym: "polysaccharide assembly with MHC class II protein complex" NARROW [] is_a: GO:0030246 ! carbohydrate binding intersection_of: GO:0005488 ! binding intersection_of: RO:0004009 CHEBI:18154 ! has primary input relationship: RO:0004009 CHEBI:18154 ! has primary input [Term] id: GO:0030252 name: growth hormone secretion namespace: biological_process def: "The regulated release of growth hormone from secretory granules into the blood." [GOC:mah] synonym: "somatotropin secretion" EXACT [GOC:mah] is_a: GO:0030072 ! peptide hormone secretion [Term] id: GO:0030261 name: chromosome condensation namespace: biological_process def: "The progressive compaction of dispersed interphase chromatin into threadlike chromosomes prior to mitotic or meiotic nuclear division, or during apoptosis, in eukaryotic cells." [GOC:mah, ISBN:0815316194] synonym: "DNA condensation" BROAD [Wikipedia:DNA_condensation] synonym: "eukaryotic chromosome condensation" EXACT [GOC:bf] synonym: "nuclear chromosome condensation" EXACT [GOC:bf] is_a: GO:0051276 ! chromosome organization [Term] id: GO:0030262 name: apoptotic nuclear changes namespace: biological_process def: "Alterations undergone by nuclei at the molecular and morphological level as part of the execution phase of apoptosis." [GOC:mah, GOC:mtg_apoptosis] synonym: "apoptotic nuclear change" NARROW [] is_a: GO:0006921 ! cellular component disassembly involved in execution phase of apoptosis property_value: RO:0002161 NCBITaxon:4896 [Term] id: GO:0030263 name: apoptotic chromosome condensation namespace: biological_process def: "The compaction of chromatin during apoptosis." [GOC:mah] synonym: "pyknosis" EXACT [] xref: Wikipedia:Pyknosis is_a: GO:0030261 ! chromosome condensation relationship: BFO:0000050 GO:0030262 ! part of apoptotic nuclear changes property_value: RO:0002161 NCBITaxon:4896 [Term] id: GO:0030264 name: nuclear fragmentation involved in apoptotic nuclear change namespace: biological_process def: "The breakdown of the nucleus into small membrane-bounded compartments, or blebs, each of which contain compacted DNA." [GOC:dph, GOC:mah, GOC:mtg_apoptosis, GOC:tb, ISBN:0721639976] synonym: "apoptotic nuclear fragmentation" EXACT [] synonym: "nuclear fragmentation during apoptosis" RELATED [GOC:dph, GOC:tb] synonym: "nucleus fragmentation" EXACT [] is_a: GO:0071763 ! nuclear membrane organization intersection_of: GO:0071763 ! nuclear membrane organization intersection_of: BFO:0000050 GO:0030262 ! part of apoptotic nuclear changes relationship: BFO:0000050 GO:0030262 ! part of apoptotic nuclear changes property_value: RO:0002161 NCBITaxon:4896 [Term] id: GO:0030278 name: regulation of ossification namespace: biological_process def: "Any process that modulates the frequency, rate or extent of ossification, the formation of bone or of a bony substance or the conversion of fibrous tissue or of cartilage into bone or a bony substance." [GOC:go_curators] synonym: "regulation of bone biosynthesis" EXACT [] synonym: "regulation of bone formation" EXACT [] is_a: GO:0051239 ! regulation of multicellular organismal process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0001503 ! regulates ossification relationship: RO:0002211 GO:0001503 ! regulates ossification [Term] id: GO:0030279 name: negative regulation of ossification namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of ossification, the formation of bone or of a bony substance or the conversion of fibrous tissue or of cartilage into bone or a bony substance." [GOC:go_curators] synonym: "down regulation of ossification" EXACT [] synonym: "down-regulation of ossification" EXACT [] synonym: "downregulation of ossification" EXACT [] synonym: "inhibition of ossification" NARROW [] synonym: "negative regulation of bone biosynthesis" EXACT [] synonym: "negative regulation of bone formation" EXACT [] is_a: GO:0030278 ! regulation of ossification is_a: GO:0051241 ! negative regulation of multicellular organismal process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0001503 ! negatively regulates ossification relationship: RO:0002212 GO:0001503 ! negatively regulates ossification [Term] id: GO:0030282 name: bone mineralization namespace: biological_process def: "The deposition of hydroxyapatite, a form of calcium phosphate with the formula Ca10(PO4)6(OH)2, in bone tissue." [GOC:mah, PMID:22936354] synonym: "bone calcification" NARROW [] is_a: GO:0031214 ! biomineral tissue development intersection_of: GO:0031214 ! biomineral tissue development intersection_of: RO:0002299 UBERON:0001474 ! results in maturation of bone element relationship: BFO:0000050 GO:0001503 ! part of ossification relationship: RO:0002299 UBERON:0001474 ! results in maturation of bone element [Term] id: GO:0030286 name: dynein complex namespace: cellular_component def: "Any of several large complexes that contain two or three dynein heavy chains and several light chains, and have microtubule motor activity." [ISBN:0815316194] is_a: GO:0005875 ! microtubule associated complex is_a: GO:1902494 ! catalytic complex relationship: RO:0002215 GO:0003777 ! capable of microtubule motor activity [Term] id: GO:0030307 name: positive regulation of cell growth namespace: biological_process def: "Any process that activates or increases the frequency, rate, extent or direction of cell growth." [GOC:go_curators] synonym: "activation of cell growth" NARROW [] synonym: "stimulation of cell growth" NARROW [] synonym: "up regulation of cell growth" EXACT [] synonym: "up-regulation of cell growth" EXACT [] synonym: "upregulation of cell growth" EXACT [] is_a: GO:0001558 ! regulation of cell growth is_a: GO:0045927 ! positive regulation of growth is_a: GO:0048522 ! positive regulation of cellular process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0016049 ! positively regulates cell growth relationship: RO:0002213 GO:0016049 ! positively regulates cell growth [Term] id: GO:0030308 name: negative regulation of cell growth namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, extent or direction of cell growth." [GOC:go_curators] synonym: "down regulation of cell growth" EXACT [] synonym: "down-regulation of cell growth" EXACT [] synonym: "downregulation of cell growth" EXACT [] synonym: "inhibition of cell growth" NARROW [] is_a: GO:0001558 ! regulation of cell growth is_a: GO:0045926 ! negative regulation of growth is_a: GO:0048523 ! negative regulation of cellular process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0016049 ! negatively regulates cell growth relationship: RO:0002212 GO:0016049 ! negatively regulates cell growth [Term] id: GO:0030312 name: external encapsulating structure namespace: cellular_component def: "A structure that lies outside the plasma membrane and surrounds the entire cell or cells. This does not include the periplasmic space." [GOC:go_curators] comment: The outer membrane (of gram negative bacteria) or cell wall (of yeast or Gram positive bacteria) are defined as parts of this structure, see 'external encapsulating structure part'. subset: goslim_chembl subset: goslim_drosophila subset: goslim_generic subset: goslim_pir subset: goslim_plant is_a: GO:0110165 ! cellular anatomical structure relationship: BFO:0000050 GO:0071944 ! part of cell periphery property_value: skos:prefLabel "external encapsulating structure" xsd:string [Term] id: GO:0030316 name: osteoclast differentiation namespace: biological_process def: "The process in which a relatively unspecialized monocyte acquires the specialized features of an osteoclast. An osteoclast is a specialized phagocytic cell associated with the absorption and removal of the mineralized matrix of bone tissue." [CL:0000092, GOC:add, ISBN:0781735149, PMID:12161749] synonym: "osteoclast cell differentiation" EXACT [] is_a: GO:0002573 ! myeloid leukocyte differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000092 ! results in acquisition of features of osteoclast relationship: RO:0002315 CL:0000092 ! results in acquisition of features of osteoclast [Term] id: GO:0030317 name: flagellated sperm motility namespace: biological_process def: "The directed, self-propelled movement of a cilium (aka flagellum) that contributes to the movement of a flagellated sperm." [GO_REF:0000060, GOC:cilia, GOC:krc, GOC:TermGenie, PMID:26680031] synonym: "flagellated sperm movement" EXACT [] synonym: "sperm flagellum movement" EXACT [GOC:cilia, GOC:krc] synonym: "sperm flagellum movement involved in flagellated sperm motility" EXACT [] synonym: "sperm flagellum movement involved in flagellated sperm movement" EXACT [GOC:TermGenie] synonym: "sperm motility" BROAD [] synonym: "sperm movement" BROAD [] xref: Wikipedia:Sperm_motility is_a: GO:0060285 ! cilium-dependent cell motility is_a: GO:0060294 ! cilium movement involved in cell motility is_a: GO:0097722 ! sperm motility intersection_of: GO:0060285 ! cilium-dependent cell motility intersection_of: RO:0002565 CL:0000019 ! results in movement of sperm property_value: RO:0002161 NCBITaxon:3176 property_value: RO:0002161 NCBITaxon:3378 property_value: RO:0002161 NCBITaxon:3398 property_value: RO:0002161 NCBITaxon:4890 property_value: RO:0002161 NCBITaxon:5782 [Term] id: GO:0030318 name: melanocyte differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a melanocyte." [GOC:mah] synonym: "melanocyte cell differentiation" EXACT [] synonym: "melanophore differentiation" EXACT [] is_a: GO:0050931 ! pigment cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000148 ! results in acquisition of features of melanocyte relationship: RO:0002315 CL:0000148 ! results in acquisition of features of melanocyte [Term] id: GO:0030323 name: respiratory tube development namespace: biological_process def: "The process whose specific outcome is the progression of the respiratory tube over time, from its formation to the mature structure. The respiratory tube is assumed to mean any tube in the respiratory tract." [GOC:jid] is_a: GO:0035295 ! tube development is_a: GO:0048513 ! animal organ development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0000117 ! results in development of respiratory tube relationship: RO:0002296 UBERON:0000117 ! results in development of respiratory tube [Term] id: GO:0030324 name: lung development namespace: biological_process def: "The process whose specific outcome is the progression of the lung over time, from its formation to the mature structure. In all air-breathing vertebrates the lungs are developed from the ventral wall of the oesophagus as a pouch which divides into two sacs. In amphibians and many reptiles the lungs retain very nearly this primitive sac-like character, but in the higher forms the connection with the esophagus becomes elongated into the windpipe and the inner walls of the sacs become more and more divided, until, in the mammals, the air spaces become minutely divided into tubes ending in small air cells, in the walls of which the blood circulates in a fine network of capillaries. In mammals the lungs are more or less divided into lobes, and each lung occupies a separate cavity in the thorax." [GOC:jid, UBERON:0002048] is_a: GO:0048513 ! animal organ development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0002048 ! results in development of lung relationship: BFO:0000050 GO:0030323 ! part of respiratory tube development relationship: BFO:0000050 GO:0060541 ! part of respiratory system development relationship: RO:0002162 NCBITaxon:7776 ! in taxon Gnathostomata relationship: RO:0002296 UBERON:0002048 ! results in development of lung [Term] id: GO:0030325 name: adrenal gland development namespace: biological_process def: "The process whose specific outcome is the progression of the adrenal gland over time, from its formation to the mature structure. This gland can either be a discrete structure located bilaterally above each kidney, or a cluster of cells in the head kidney that perform the functions of the adrenal gland. In either case, this organ consists of two cells types, aminergic chromaffin cells and steroidogenic cortical cells." [GOC:dgh] synonym: "interrenal gland" RELATED [] is_a: GO:0048732 ! gland development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0002369 ! results in development of adrenal gland relationship: BFO:0000050 GO:0035270 ! part of endocrine system development relationship: RO:0002296 UBERON:0002369 ! results in development of adrenal gland [Term] id: GO:0030331 name: nuclear estrogen receptor binding namespace: molecular_function def: "Binding to a nuclear estrogen receptor." [GOC:ai] synonym: "estrogen receptor binding" BROAD [] is_a: GO:0016922 ! nuclear receptor binding intersection_of: GO:0005488 ! binding intersection_of: RO:0004009 PR:000007204 ! has primary input estrogen receptor relationship: RO:0004009 PR:000007204 ! has primary input estrogen receptor property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/16717" xsd:anyURI property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4751 [Term] id: GO:0030334 name: regulation of cell migration namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cell migration." [GOC:go_curators] is_a: GO:2000145 ! regulation of cell motility intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0016477 ! regulates cell migration relationship: RO:0002211 GO:0016477 ! regulates cell migration property_value: RO:0002161 NCBITaxon:451864 [Term] id: GO:0030335 name: positive regulation of cell migration namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cell migration." [GOC:go_curators] synonym: "activation of cell migration" NARROW [] synonym: "stimulation of cell migration" NARROW [] synonym: "up regulation of cell migration" EXACT [] synonym: "up-regulation of cell migration" EXACT [] synonym: "upregulation of cell migration" EXACT [] is_a: GO:0030334 ! regulation of cell migration is_a: GO:2000147 ! positive regulation of cell motility intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0016477 ! positively regulates cell migration relationship: RO:0002213 GO:0016477 ! positively regulates cell migration property_value: RO:0002161 NCBITaxon:451864 [Term] id: GO:0030336 name: negative regulation of cell migration namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cell migration." [GOC:go_curators] synonym: "down regulation of cell migration" EXACT [] synonym: "down-regulation of cell migration" EXACT [] synonym: "downregulation of cell migration" EXACT [] synonym: "inhibition of cell migration" NARROW [] is_a: GO:0030334 ! regulation of cell migration is_a: GO:2000146 ! negative regulation of cell motility intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0016477 ! negatively regulates cell migration relationship: RO:0002212 GO:0016477 ! negatively regulates cell migration property_value: RO:0002161 NCBITaxon:451864 [Term] id: GO:0030382 name: sperm mitochondrion organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of sperm mitochondria; the process in which they take on their characteristic morphology; they are flattened, elongated, and arranged circumferentially into a tight helical coil around the tail-dense fibers of the mature sperm." [GOC:dph, GOC:jl, GOC:mah, PMID:8833144] synonym: "sperm mitochondria organisation" EXACT [] synonym: "sperm mitochondria organization and biogenesis" RELATED [GOC:mah] synonym: "sperm mitochondrion organization and biogenesis" RELATED [GOC:mah] is_a: GO:0007005 ! mitochondrion organization intersection_of: GO:0016043 ! cellular component organization intersection_of: BFO:0000066 CL:0000019 ! occurs in sperm intersection_of: RO:0002592 GO:0005739 ! results in organization of mitochondrion relationship: BFO:0000066 CL:0000019 ! occurs in sperm [Term] id: GO:0030397 name: membrane disassembly namespace: biological_process def: "The controlled breakdown of any cell membrane in the context of a normal process such as autophagy." [GOC:mah] synonym: "membrane breakdown" EXACT [] synonym: "membrane catabolism" EXACT [] synonym: "membrane degradation" EXACT [] is_a: GO:0022411 ! cellular component disassembly is_a: GO:0061024 ! membrane organization intersection_of: GO:0022411 ! cellular component disassembly intersection_of: RO:0002590 GO:0016020 ! results in disassembly of membrane relationship: RO:0002590 GO:0016020 ! results in disassembly of membrane [Term] id: GO:0030421 name: defecation namespace: biological_process def: "The expulsion of feces from the rectum." [GOC:mah] xref: Wikipedia:Defecation is_a: GO:0007588 ! excretion is_a: GO:0022600 ! digestive system process property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0030424 name: axon namespace: cellular_component def: "The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter." [GOC:nln, ISBN:0198506732] xref: NIF_Subcellular:sao1770195789 xref: Wikipedia:Axon is_a: GO:0043005 ! neuron projection property_value: skos:prefLabel "axon" xsd:string [Term] id: GO:0030425 name: dendrite namespace: cellular_component def: "A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body." [GOC:aruk, GOC:bc, GOC:dos, GOC:mah, GOC:nln, ISBN:0198506732] xref: NIF_Subcellular:sao1211023249 xref: Wikipedia:Dendrite is_a: GO:0043005 ! neuron projection relationship: BFO:0000050 GO:0097447 ! part of dendritic tree property_value: skos:prefLabel "dendrite" xsd:string [Term] id: GO:0030432 name: peristalsis namespace: biological_process def: "A wavelike sequence of involuntary muscular contraction and relaxation that passes along a tubelike structure, such as the intestine, impelling the contents onwards." [ISBN:0198506732] xref: Wikipedia:Peristalsis is_a: GO:0014821 ! phasic smooth muscle contraction property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0030435 name: sporulation resulting in formation of a cellular spore namespace: biological_process def: "The process in which a relatively unspecialized cell acquires the specialized features of a cellular spore, a cell form that can be used for dissemination, for survival of adverse conditions because of its heat and desiccation resistance, and/or for reproduction." [GOC:mah, GOC:pamgo_curators, ISBN:0072992913] comment: Note that the synonym 'spore differentiation', like the term name and definition, refers to differentiation into a spore rather than any subsequent developmental changes that a spore may undergo. synonym: "cellular spore formation by sporulation" EXACT [GOC:dph, GOC:tb] synonym: "spore biosynthesis" EXACT [] synonym: "spore differentiation" EXACT [] synonym: "spore formation" EXACT [] xref: Wikipedia:Sporogenesis is_a: GO:0043934 ! sporulation is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/24410" xsd:anyURI [Term] id: GO:0030437 name: ascospore formation namespace: biological_process def: "The process in which cells that are products of meiosis acquire the specialized features of ascospores. Ascospores are generally found in clusters of four or eight spores within a single mother cell, the ascus, and are characteristic of the ascomycete fungi (phylum Ascomycota)." [GOC:di, GOC:mah, GOC:mcc, PMID:16339736] comment: Note that ascospores and asci are separate biological structures. The ascus is the structure that contain the ascospores, but the development of the ascus is a different process than the formation of the ascospores themselves; for instance, some mutations affect sporulation without affecting ascus development. For this reason, GO:0030437 ascospore formation and GO:0075317 ascus development are different terms and are not linked. subset: goslim_pombe synonym: "ascospore biosynthesis" EXACT [] synonym: "spore formation" BROAD [] synonym: "sporulation" BROAD [] is_a: GO:0022413 ! reproductive process in single-celled organism is_a: GO:0043935 ! sexual sporulation resulting in formation of a cellular spore is_a: GO:0048468 ! cell development is_a: GO:1903046 ! meiotic cell cycle process intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 CL:0000607 ! results in formation of anatomical entity ascospore relationship: RO:0002162 NCBITaxon:4890 ! in taxon Ascomycota relationship: RO:0002297 CL:0000607 ! results in formation of anatomical entity ascospore [Term] id: GO:0030473 name: nuclear migration along microtubule namespace: biological_process def: "The directed movement of the nucleus along microtubules within the cell, mediated by motor proteins." [GOC:mah, GOC:sgd_curators] synonym: "microtubule cytoskeleton-dependent nuclear positioning" EXACT [] synonym: "microtubule cytoskeleton-dependent nucleus positioning" EXACT [] synonym: "microtubule-dependent nuclear positioning" EXACT [] synonym: "microtubule-dependent nucleus positioning" EXACT [] synonym: "microtubule-mediated nuclear migration" EXACT [] synonym: "nuclear migration, microtubule-mediated" EXACT [] synonym: "nuclear movement, microtubule-mediated" BROAD [] synonym: "nucleus migration" BROAD [] synonym: "transport of nucleus by microtubules" EXACT [] synonym: "transport of nucleus, microtubule-mediated" EXACT [] is_a: GO:0007097 ! nuclear migration is_a: GO:0072384 ! organelle transport along microtubule intersection_of: GO:0007097 ! nuclear migration intersection_of: RO:0002341 GO:0015630 ! results in transport along microtubule cytoskeleton relationship: RO:0002341 GO:0015630 ! results in transport along microtubule cytoskeleton [Term] id: GO:0030485 name: smooth muscle contractile fiber namespace: cellular_component def: "The contractile fiber of smooth muscle cells." [GOC:mah] is_a: GO:0043292 ! contractile muscle fiber intersection_of: GO:0043292 ! contractile muscle fiber intersection_of: BFO:0000050 CL:0000192 ! part of smooth muscle cell relationship: BFO:0000050 CL:0000192 ! part of smooth muscle cell [Term] id: GO:0030500 name: regulation of bone mineralization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of bone mineralization." [GOC:go_curators] is_a: GO:0030278 ! regulation of ossification is_a: GO:0070167 ! regulation of biomineral tissue development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0030282 ! regulates bone mineralization relationship: RO:0002211 GO:0030282 ! regulates bone mineralization [Term] id: GO:0030501 name: positive regulation of bone mineralization namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of bone mineralization." [GOC:go_curators] synonym: "activation of bone mineralization" NARROW [] synonym: "stimulation of bone mineralization" NARROW [] synonym: "up regulation of bone mineralization" EXACT [] synonym: "up-regulation of bone mineralization" EXACT [] synonym: "upregulation of bone mineralization" EXACT [] is_a: GO:0030500 ! regulation of bone mineralization is_a: GO:0045778 ! positive regulation of ossification is_a: GO:0070169 ! positive regulation of biomineral tissue development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0030282 ! positively regulates bone mineralization relationship: RO:0002213 GO:0030282 ! positively regulates bone mineralization [Term] id: GO:0030502 name: negative regulation of bone mineralization namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of bone mineralization." [GOC:go_curators] synonym: "down regulation of bone mineralization" EXACT [] synonym: "down-regulation of bone mineralization" EXACT [] synonym: "downregulation of bone mineralization" EXACT [] synonym: "inhibition of bone mineralization" NARROW [] is_a: GO:0030279 ! negative regulation of ossification is_a: GO:0030500 ! regulation of bone mineralization is_a: GO:0070168 ! negative regulation of biomineral tissue development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0030282 ! negatively regulates bone mineralization relationship: RO:0002212 GO:0030282 ! negatively regulates bone mineralization [Term] id: GO:0030539 name: male genitalia development namespace: biological_process def: "The process whose specific outcome is the progression of the male genitalia over time, from its formation to the mature structure." [GOC:ems, ISBN:0140512888] synonym: "male genital development" EXACT [] is_a: GO:0048806 ! genitalia development is_a: GO:0061458 ! reproductive system development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0000079 ! results in development of male reproductive system relationship: BFO:0000050 GO:0046661 ! part of male sex differentiation relationship: RO:0002296 UBERON:0000079 ! results in development of male reproductive system property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0030540 name: female genitalia development namespace: biological_process def: "The process whose specific outcome is the progression of the female genitalia over time, from formation to the mature structure." [GOC:mah] synonym: "female genital development" EXACT [] is_a: GO:0048806 ! genitalia development relationship: BFO:0000050 GO:0046660 ! part of female sex differentiation property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0030554 name: adenyl nucleotide binding namespace: molecular_function def: "Binding to an adenyl nucleotide, an adenosine esterified with (ortho)phosphate." [ISBN:0198506732] subset: goslim_chembl is_a: GO:0017076 ! purine nucleotide binding intersection_of: GO:0005488 ! binding intersection_of: RO:0004009 CHEBI:61293 ! has primary input relationship: RO:0004009 CHEBI:61293 ! has primary input [Term] id: GO:0030573 name: bile acid catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of bile acids, any of a group of steroid carboxylic acids occurring in bile." [GOC:go_curators] synonym: "bile acid 7alpha-dehydroxylation pathway" NARROW [] synonym: "bile acid breakdown" EXACT [] synonym: "bile acid catabolism" EXACT [] synonym: "bile acid degradation" EXACT [] synonym: "cholate catabolic process" NARROW [] is_a: GO:0008206 ! bile acid metabolic process is_a: GO:0072329 ! monocarboxylic acid catabolic process intersection_of: GO:0009056 ! catabolic process intersection_of: RO:0004009 CHEBI:36235 ! has primary input relationship: RO:0004009 CHEBI:36235 ! has primary input [Term] id: GO:0030574 name: collagen catabolic process namespace: biological_process def: "The proteolytic chemical reactions and pathways resulting in the breakdown of collagen in the extracellular matrix, usually carried out by proteases secreted by nearby cells." [GOC:mah, ISBN:0815316194] synonym: "collagen breakdown" EXACT [] synonym: "collagen catabolism" EXACT [] synonym: "collagen degradation" EXACT [] xref: Reactome:R-HSA-1442490 "Collagen degradation" is_a: GO:0009056 ! catabolic process is_a: GO:0032963 ! collagen metabolic process intersection_of: GO:0009056 ! catabolic process intersection_of: RO:0004009 GO:0005581 ! has primary input collagen trimer relationship: RO:0004009 GO:0005581 ! has primary input collagen trimer [Term] id: GO:0030593 name: neutrophil chemotaxis namespace: biological_process def: "The directed movement of a neutrophil cell, the most numerous polymorphonuclear leukocyte found in the blood, in response to an external stimulus, usually an infection or wounding." [GOC:jl, ISBN:0198506732] is_a: GO:0071621 ! granulocyte chemotaxis is_a: GO:1990266 ! neutrophil migration intersection_of: GO:0006935 ! chemotaxis intersection_of: RO:0002565 CL:0000775 ! results in movement of neutrophil [Term] id: GO:0030594 name: neurotransmitter receptor activity namespace: molecular_function def: "Combining with a neurotransmitter and transmitting the signal to initiate a change in cell activity." [GOC:jl, GOC:signaling] comment: A strict definition of neurotransmitter receptor activity would limit its use to receptor activity at the postsynaptic membrane as part of synaptic transmission, but we recognize that usage is often much broader than this. For the strict use case, please see 'postsynaptic neurotransmitter receptor activity' is_a: GO:0038023 ! signaling receptor activity relationship: RO:0002162 NCBITaxon:33208 ! in taxon Metazoa [Term] id: GO:0030595 name: leukocyte chemotaxis namespace: biological_process def: "The movement of a leukocyte in response to an external stimulus." [GOC:add, GOC:jl] synonym: "immune cell chemotaxis" EXACT [] synonym: "leucocyte chemotaxis" EXACT [] is_a: GO:0050900 ! leukocyte migration is_a: GO:0060326 ! cell chemotaxis intersection_of: GO:0006935 ! chemotaxis intersection_of: RO:0002565 CL:0000738 ! results in movement of leukocyte [Term] id: GO:0030643 name: intracellular phosphate ion homeostasis namespace: biological_process def: "A homeostatic process involved in the maintenance of a steady state level of phosphate ions within a cell." [GOC:mah] subset: goslim_pombe synonym: "cellular phosphate ion homeostasis" EXACT [] synonym: "intracellular phosphate homeostasis" BROAD [] synonym: "intracellular Pi homeostasis" EXACT [] is_a: GO:0055062 ! phosphate ion homeostasis is_a: GO:0055082 ! intracellular chemical homeostasis intersection_of: GO:0019725 ! cellular homeostasis intersection_of: RO:0002332 CHEBI:43474 ! regulates levels of property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/26429" xsd:anyURI [Term] id: GO:0030658 name: transport vesicle membrane namespace: cellular_component def: "The lipid bilayer surrounding a transport vesicle." [GOC:mah] synonym: "constitutive secretory pathway transport vesicle membrane" EXACT [] synonym: "secretory vesicle membrane" BROAD [] is_a: GO:0030659 ! cytoplasmic vesicle membrane is_a: GO:0098588 ! bounding membrane of organelle intersection_of: GO:0016020 ! membrane intersection_of: RO:0002007 GO:0030133 ! bounding layer of transport vesicle relationship: RO:0002007 GO:0030133 ! bounding layer of transport vesicle [Term] id: GO:0030659 name: cytoplasmic vesicle membrane namespace: cellular_component def: "The lipid bilayer surrounding a cytoplasmic vesicle." [GOC:mah] is_a: GO:0012506 ! vesicle membrane intersection_of: GO:0016020 ! membrane intersection_of: BFO:0000050 GO:0031410 ! part of cytoplasmic vesicle relationship: BFO:0000050 GO:0031410 ! part of cytoplasmic vesicle [Term] id: GO:0030660 name: Golgi-associated vesicle membrane namespace: cellular_component def: "The lipid bilayer surrounding a vesicle associated with the Golgi apparatus." [GOC:mah] synonym: "Golgi vesicle membrane" RELATED [] is_a: GO:0030659 ! cytoplasmic vesicle membrane is_a: GO:0098588 ! bounding membrane of organelle intersection_of: GO:0016020 ! membrane intersection_of: RO:0002007 GO:0005798 ! bounding layer of Golgi-associated vesicle relationship: RO:0002007 GO:0005798 ! bounding layer of Golgi-associated vesicle [Term] id: GO:0030661 name: chitosome membrane namespace: cellular_component def: "The lipid bilayer surrounding a chitosome." [GOC:mah] is_a: GO:0030659 ! cytoplasmic vesicle membrane is_a: GO:0098588 ! bounding membrane of organelle intersection_of: GO:0016020 ! membrane intersection_of: RO:0002007 GO:0045009 ! bounding layer of chitosome relationship: RO:0002007 GO:0045009 ! bounding layer of chitosome [Term] id: GO:0030662 name: coated vesicle membrane namespace: cellular_component def: "The lipid bilayer surrounding a coated vesicle." [GOC:mah] is_a: GO:0030659 ! cytoplasmic vesicle membrane is_a: GO:0098588 ! bounding membrane of organelle intersection_of: GO:0016020 ! membrane intersection_of: RO:0002007 GO:0030135 ! bounding layer of coated vesicle relationship: RO:0002007 GO:0030135 ! bounding layer of coated vesicle [Term] id: GO:0030665 name: clathrin-coated vesicle membrane namespace: cellular_component def: "The lipid bilayer surrounding a clathrin-coated vesicle." [GOC:mah] synonym: "clathrin coated vesicle membrane" NARROW [GOC:sl] is_a: GO:0030662 ! coated vesicle membrane intersection_of: GO:0016020 ! membrane intersection_of: RO:0002007 GO:0030136 ! bounding layer of clathrin-coated vesicle relationship: RO:0002007 GO:0030136 ! bounding layer of clathrin-coated vesicle [Term] id: GO:0030667 name: secretory granule membrane namespace: cellular_component def: "The lipid bilayer surrounding a secretory granule." [GOC:mah] synonym: "secretory vesicle membrane" BROAD [] is_a: GO:0030659 ! cytoplasmic vesicle membrane is_a: GO:0098588 ! bounding membrane of organelle intersection_of: GO:0016020 ! membrane intersection_of: RO:0002007 GO:0030141 ! bounding layer of secretory granule relationship: RO:0002007 GO:0030141 ! bounding layer of secretory granule property_value: RO:0002161 NCBITaxon:4890 [Term] id: GO:0030705 name: cytoskeleton-dependent intracellular transport namespace: biological_process def: "The directed movement of substances along cytoskeletal fibers such as microfilaments or microtubules within a cell." [GOC:mah] subset: goslim_chembl subset: goslim_drosophila is_a: GO:0046907 ! intracellular transport intersection_of: GO:0046907 ! intracellular transport intersection_of: RO:0002341 GO:0099513 ! results in transport along polymeric cytoskeletal fiber relationship: RO:0002341 GO:0099513 ! results in transport along polymeric cytoskeletal fiber [Term] id: GO:0030707 name: follicle cell of egg chamber development namespace: biological_process def: "The process that occurs during oogenesis involving the ovarian follicle cells, somatic cells which surround the germ cells of an ovary. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:10822261] is_a: GO:0002064 ! epithelial cell development is_a: GO:0003006 ! developmental process involved in reproduction intersection_of: GO:0048468 ! cell development intersection_of: RO:0002296 CL:0000477 ! results in development of follicle cell of egg chamber relationship: BFO:0000050 GO:0048477 ! part of oogenesis relationship: RO:0002296 CL:0000477 ! results in development of follicle cell of egg chamber [Term] id: GO:0030718 name: germ-line stem cell population maintenance namespace: biological_process def: "Any process by which an organism or tissue maintains a population of germ-line stem cells." [ISBN:0879694238] is_a: GO:0019827 ! stem cell population maintenance intersection_of: GO:0098727 ! maintenance of cell number intersection_of: RO:0012003 CL:0000014 ! acts on population of germ line stem cell relationship: RO:0012003 CL:0000014 ! acts on population of germ line stem cell property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0030720 name: oocyte localization involved in germarium-derived egg chamber formation namespace: biological_process def: "Directed movement of the oocyte, following its specification, from its original central position in the cyst to a posterior position relative to the nurse cells of the egg chamber, and its maintenance in this posterior location. This is the first sign of anterior-posterior asymmetry in the developing egg chamber." [GOC:mtg_sensu, PMID:10449356] synonym: "establishment and maintenance of oocyte localization in egg chamber" EXACT [] synonym: "establishment and maintenance of oocyte position during oogenesis" EXACT [] synonym: "oocyte localisation involved in germarium-derived egg chamber formation" EXACT [GOC:mah] synonym: "oocyte localization during germarium-derived egg chamber formation" RELATED [GOC:dph, GOC:tb] synonym: "oocyte localization during oogenesis" RELATED [] synonym: "oocyte positioning during oogenesis" NARROW [] synonym: "oogenesis, establishment and maintenance of oocyte localization" EXACT [] synonym: "oogenesis, oocyte localization" EXACT [] is_a: GO:0051674 ! localization of cell intersection_of: GO:0051179 ! localization intersection_of: RO:0004009 CL:0000023 ! has primary input oocyte relationship: BFO:0000050 GO:0007293 ! part of germarium-derived egg chamber formation relationship: RO:0002162 NCBITaxon:50557 ! in taxon Insecta relationship: RO:0004009 CL:0000023 ! has primary input oocyte [Term] id: GO:0030808 name: regulation of nucleotide biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of nucleotides." [GOC:mah] synonym: "regulation of nucleotide anabolism" EXACT [] synonym: "regulation of nucleotide biosynthesis" EXACT [] synonym: "regulation of nucleotide formation" EXACT [] synonym: "regulation of nucleotide synthesis" EXACT [] is_a: GO:0006140 ! regulation of nucleotide metabolic process is_a: GO:0009889 ! regulation of biosynthetic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0009165 ! regulates nucleotide biosynthetic process relationship: RO:0002211 GO:0009165 ! regulates nucleotide biosynthetic process [Term] id: GO:0030809 name: negative regulation of nucleotide biosynthetic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of nucleotides." [GOC:mah] synonym: "down regulation of nucleotide biosynthetic process" EXACT [] synonym: "down-regulation of nucleotide biosynthetic process" EXACT [] synonym: "downregulation of nucleotide biosynthetic process" EXACT [] synonym: "inhibition of nucleotide biosynthetic process" NARROW [] synonym: "negative regulation of nucleotide anabolism" EXACT [] synonym: "negative regulation of nucleotide biosynthesis" EXACT [] synonym: "negative regulation of nucleotide formation" EXACT [] synonym: "negative regulation of nucleotide synthesis" EXACT [] is_a: GO:0009890 ! negative regulation of biosynthetic process is_a: GO:0030808 ! regulation of nucleotide biosynthetic process is_a: GO:0045980 ! negative regulation of nucleotide metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0009165 ! negatively regulates nucleotide biosynthetic process relationship: RO:0002212 GO:0009165 ! negatively regulates nucleotide biosynthetic process [Term] id: GO:0030810 name: positive regulation of nucleotide biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of nucleotides." [GOC:mah] synonym: "activation of nucleotide biosynthetic process" NARROW [] synonym: "positive regulation of nucleotide anabolism" EXACT [] synonym: "positive regulation of nucleotide biosynthesis" EXACT [] synonym: "positive regulation of nucleotide formation" EXACT [] synonym: "positive regulation of nucleotide synthesis" EXACT [] synonym: "stimulation of nucleotide biosynthetic process" NARROW [] synonym: "up regulation of nucleotide biosynthetic process" EXACT [] synonym: "up-regulation of nucleotide biosynthetic process" EXACT [] synonym: "upregulation of nucleotide biosynthetic process" EXACT [] is_a: GO:0009891 ! positive regulation of biosynthetic process is_a: GO:0030808 ! regulation of nucleotide biosynthetic process is_a: GO:0045981 ! positive regulation of nucleotide metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0009165 ! positively regulates nucleotide biosynthetic process relationship: RO:0002213 GO:0009165 ! positively regulates nucleotide biosynthetic process [Term] id: GO:0030811 name: regulation of nucleotide catabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of nucleotides." [GOC:mah] synonym: "regulation of nucleotide breakdown" EXACT [] synonym: "regulation of nucleotide catabolism" EXACT [] synonym: "regulation of nucleotide degradation" EXACT [] is_a: GO:0006140 ! regulation of nucleotide metabolic process is_a: GO:0009894 ! regulation of catabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0009166 ! regulates nucleotide catabolic process relationship: RO:0002211 GO:0009166 ! regulates nucleotide catabolic process [Term] id: GO:0030812 name: negative regulation of nucleotide catabolic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of nucleotides." [GOC:mah] synonym: "down regulation of nucleotide catabolic process" EXACT [] synonym: "down-regulation of nucleotide catabolic process" EXACT [] synonym: "downregulation of nucleotide catabolic process" EXACT [] synonym: "inhibition of nucleotide catabolic process" NARROW [] synonym: "negative regulation of nucleotide breakdown" EXACT [] synonym: "negative regulation of nucleotide catabolism" EXACT [] synonym: "negative regulation of nucleotide degradation" EXACT [] is_a: GO:0009895 ! negative regulation of catabolic process is_a: GO:0030811 ! regulation of nucleotide catabolic process is_a: GO:0045980 ! negative regulation of nucleotide metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0009166 ! negatively regulates nucleotide catabolic process relationship: RO:0002212 GO:0009166 ! negatively regulates nucleotide catabolic process [Term] id: GO:0030813 name: positive regulation of nucleotide catabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of nucleotides." [GOC:mah] synonym: "activation of nucleotide catabolic process" NARROW [] synonym: "positive regulation of nucleotide breakdown" EXACT [] synonym: "positive regulation of nucleotide catabolism" EXACT [] synonym: "positive regulation of nucleotide degradation" EXACT [] synonym: "stimulation of nucleotide catabolic process" NARROW [] synonym: "up regulation of nucleotide catabolic process" EXACT [] synonym: "up-regulation of nucleotide catabolic process" EXACT [] synonym: "upregulation of nucleotide catabolic process" EXACT [] is_a: GO:0009896 ! positive regulation of catabolic process is_a: GO:0030811 ! regulation of nucleotide catabolic process is_a: GO:0045981 ! positive regulation of nucleotide metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0009166 ! positively regulates nucleotide catabolic process relationship: RO:0002213 GO:0009166 ! positively regulates nucleotide catabolic process [Term] id: GO:0030849 name: autosome namespace: cellular_component def: "Any chromosome other than a sex chromosome." [GOC:mah] comment: Note that this term is mainly relevant in organisms that have both sex chromosomes and non-sex-determining chromosomes in an individual organism. xref: Wikipedia:Autosome is_a: GO:0005694 ! chromosome [Term] id: GO:0030850 name: prostate gland development namespace: biological_process def: "The process whose specific outcome is the progression of the prostate gland over time, from its formation to the mature structure. The prostate gland is a partly muscular, partly glandular body that is situated near the base of the mammalian male urethra and secretes an alkaline viscid fluid which is a major constituent of the ejaculatory fluid." [PMID:11839751] synonym: "prostate development" EXACT [] is_a: GO:0048608 ! reproductive structure development is_a: GO:0048732 ! gland development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0002367 ! results in development of prostate gland relationship: BFO:0000050 GO:0001655 ! part of urogenital system development relationship: RO:0002162 NCBITaxon:40674 ! in taxon Mammalia relationship: RO:0002296 UBERON:0002367 ! results in development of prostate gland [Term] id: GO:0030851 name: granulocyte differentiation namespace: biological_process def: "The process in which a myeloid precursor cell acquires the specialized features of a granulocyte. Granulocytes are a class of leukocytes characterized by the presence of granules in their cytoplasm. These cells are active in allergic immune reactions such as arthritic inflammation and rashes. This class includes basophils, eosinophils and neutrophils." [GOC:ecd, http://life.nthu.edu.tw/~g864204/dict-search1.htm] synonym: "granulocyte cell differentiation" EXACT [] xref: Reactome:R-HSA-9616222 "Transcriptional regulation of granulopoiesis" is_a: GO:0002573 ! myeloid leukocyte differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000094 ! results in acquisition of features of granulocyte relationship: RO:0002315 CL:0000094 ! results in acquisition of features of granulocyte [Term] id: GO:0030852 name: regulation of granulocyte differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of granulocyte differentiation." [GOC:mah] is_a: GO:0002761 ! regulation of myeloid leukocyte differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0030851 ! regulates granulocyte differentiation relationship: RO:0002211 GO:0030851 ! regulates granulocyte differentiation [Term] id: GO:0030853 name: negative regulation of granulocyte differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of granulocyte differentiation." [GOC:mah] synonym: "down regulation of granulocyte differentiation" EXACT [] synonym: "down-regulation of granulocyte differentiation" EXACT [] synonym: "downregulation of granulocyte differentiation" EXACT [] synonym: "inhibition of granulocyte differentiation" NARROW [] is_a: GO:0002762 ! negative regulation of myeloid leukocyte differentiation is_a: GO:0030852 ! regulation of granulocyte differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0030851 ! negatively regulates granulocyte differentiation relationship: RO:0002212 GO:0030851 ! negatively regulates granulocyte differentiation [Term] id: GO:0030854 name: positive regulation of granulocyte differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of granulocyte differentiation." [GOC:mah] synonym: "activation of granulocyte differentiation" NARROW [] synonym: "stimulation of granulocyte differentiation" NARROW [] synonym: "up regulation of granulocyte differentiation" EXACT [] synonym: "up-regulation of granulocyte differentiation" EXACT [] synonym: "upregulation of granulocyte differentiation" EXACT [] is_a: GO:0002763 ! positive regulation of myeloid leukocyte differentiation is_a: GO:0030852 ! regulation of granulocyte differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0030851 ! positively regulates granulocyte differentiation relationship: RO:0002213 GO:0030851 ! positively regulates granulocyte differentiation [Term] id: GO:0030855 name: epithelial cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of an epithelial cell, any of the cells making up an epithelium." [GOC:ecd, PMID:11839751] is_a: GO:0030154 ! cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000066 ! results in acquisition of features of epithelial cell relationship: BFO:0000050 GO:0060429 ! part of epithelium development relationship: RO:0002315 CL:0000066 ! results in acquisition of features of epithelial cell [Term] id: GO:0030856 name: regulation of epithelial cell differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of epithelial cell differentiation." [GOC:mah] is_a: GO:0045595 ! regulation of cell differentiation is_a: GO:2000026 ! regulation of multicellular organismal development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0030855 ! regulates epithelial cell differentiation relationship: RO:0002211 GO:0030855 ! regulates epithelial cell differentiation [Term] id: GO:0030857 name: negative regulation of epithelial cell differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of epithelial cell differentiation." [GOC:mah] synonym: "down regulation of epithelial cell differentiation" EXACT [] synonym: "down-regulation of epithelial cell differentiation" EXACT [] synonym: "downregulation of epithelial cell differentiation" EXACT [] synonym: "inhibition of epithelial cell differentiation" NARROW [] is_a: GO:0030856 ! regulation of epithelial cell differentiation is_a: GO:0045596 ! negative regulation of cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0030855 ! negatively regulates epithelial cell differentiation relationship: RO:0002212 GO:0030855 ! negatively regulates epithelial cell differentiation [Term] id: GO:0030858 name: positive regulation of epithelial cell differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of epithelial cell differentiation." [GOC:mah] synonym: "activation of epithelial cell differentiation" NARROW [] synonym: "stimulation of epithelial cell differentiation" NARROW [] synonym: "up regulation of epithelial cell differentiation" EXACT [] synonym: "up-regulation of epithelial cell differentiation" EXACT [] synonym: "upregulation of epithelial cell differentiation" EXACT [] is_a: GO:0030856 ! regulation of epithelial cell differentiation is_a: GO:0045597 ! positive regulation of cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0030855 ! positively regulates epithelial cell differentiation relationship: RO:0002213 GO:0030855 ! positively regulates epithelial cell differentiation [Term] id: GO:0030878 name: thyroid gland development namespace: biological_process def: "The process whose specific outcome is the progression of the thyroid gland over time, from its formation to the mature structure. The thyroid gland is an endoderm-derived gland that produces thyroid hormone." [GOC:dgh] is_a: GO:0048732 ! gland development intersection_of: GO:0048732 ! gland development intersection_of: RO:0002296 UBERON:0002046 ! results in development of thyroid gland relationship: BFO:0000050 GO:0035270 ! part of endocrine system development relationship: RO:0002162 NCBITaxon:89593 ! in taxon Craniata relationship: RO:0002296 UBERON:0002046 ! results in development of thyroid gland [Term] id: GO:0030879 name: mammary gland development namespace: biological_process def: "The process whose specific outcome is the progression of the mammary gland over time, from its formation to the mature structure. The mammary gland is a large compound sebaceous gland that in female mammals is modified to secrete milk. Its development starts with the formation of the mammary line and ends as the mature gland cycles between nursing and weaning stages." [PMID:9576833] synonym: "mammogenesis" NARROW [GOC:dph] is_a: GO:0048732 ! gland development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0001911 ! results in development of mammary gland relationship: RO:0002296 UBERON:0001911 ! results in development of mammary gland [Term] id: GO:0030885 name: regulation of myeloid dendritic cell activation namespace: biological_process def: "Any process that modulates the frequency or rate of myeloid dendritic cell activation." [GOC:mah] is_a: GO:0002694 ! regulation of leukocyte activation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0001773 ! regulates myeloid dendritic cell activation relationship: RO:0002211 GO:0001773 ! regulates myeloid dendritic cell activation [Term] id: GO:0030886 name: negative regulation of myeloid dendritic cell activation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of myeloid dendritic cell activation." [GOC:mah] synonym: "down regulation of myeloid dendritic cell activation" EXACT [] synonym: "down-regulation of myeloid dendritic cell activation" EXACT [] synonym: "downregulation of myeloid dendritic cell activation" EXACT [] synonym: "inhibition of myeloid dendritic cell activation" NARROW [] is_a: GO:0002695 ! negative regulation of leukocyte activation is_a: GO:0030885 ! regulation of myeloid dendritic cell activation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0001773 ! negatively regulates myeloid dendritic cell activation relationship: RO:0002212 GO:0001773 ! negatively regulates myeloid dendritic cell activation [Term] id: GO:0030887 name: positive regulation of myeloid dendritic cell activation namespace: biological_process def: "Any process that stimulates, induces or increases the rate of myeloid dendritic cell activation." [GOC:mah] synonym: "activation of myeloid dendritic cell activation" NARROW [] synonym: "stimulation of myeloid dendritic cell activation" NARROW [] synonym: "up regulation of myeloid dendritic cell activation" EXACT [] synonym: "up-regulation of myeloid dendritic cell activation" EXACT [] synonym: "upregulation of myeloid dendritic cell activation" EXACT [] is_a: GO:0002696 ! positive regulation of leukocyte activation is_a: GO:0030885 ! regulation of myeloid dendritic cell activation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0001773 ! positively regulates myeloid dendritic cell activation relationship: RO:0002213 GO:0001773 ! positively regulates myeloid dendritic cell activation [Term] id: GO:0030888 name: regulation of B cell proliferation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of B cell proliferation." [GOC:mah] synonym: "regulation of B lymphocyte proliferation" EXACT [] synonym: "regulation of B-cell proliferation" EXACT [] synonym: "regulation of B-lymphocyte proliferation" EXACT [] is_a: GO:0050670 ! regulation of lymphocyte proliferation is_a: GO:0050864 ! regulation of B cell activation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0042100 ! regulates B cell proliferation relationship: RO:0002211 GO:0042100 ! regulates B cell proliferation [Term] id: GO:0030889 name: negative regulation of B cell proliferation namespace: biological_process def: "Any process that stops, prevents or reduces the rate or extent of B cell proliferation." [GOC:mah] synonym: "down regulation of B cell proliferation" EXACT [] synonym: "down-regulation of B cell proliferation" EXACT [] synonym: "downregulation of B cell proliferation" EXACT [] synonym: "inhibition of B cell proliferation" NARROW [] synonym: "negative regulation of B lymphocyte proliferation" EXACT [] synonym: "negative regulation of B-cell proliferation" EXACT [] synonym: "negative regulation of B-lymphocyte proliferation" EXACT [] is_a: GO:0030888 ! regulation of B cell proliferation is_a: GO:0050672 ! negative regulation of lymphocyte proliferation is_a: GO:0050869 ! negative regulation of B cell activation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0042100 ! negatively regulates B cell proliferation relationship: RO:0002212 GO:0042100 ! negatively regulates B cell proliferation [Term] id: GO:0030890 name: positive regulation of B cell proliferation namespace: biological_process def: "Any process that activates or increases the rate or extent of B cell proliferation." [GOC:mah] synonym: "activation of B cell proliferation" NARROW [] synonym: "positive regulation of B lymphocyte proliferation" EXACT [] synonym: "positive regulation of B-cell proliferation" EXACT [] synonym: "positive regulation of B-lymphocyte proliferation" EXACT [] synonym: "stimulation of B cell proliferation" NARROW [] synonym: "up regulation of B cell proliferation" EXACT [] synonym: "up-regulation of B cell proliferation" EXACT [] synonym: "upregulation of B cell proliferation" EXACT [] is_a: GO:0030888 ! regulation of B cell proliferation is_a: GO:0050671 ! positive regulation of lymphocyte proliferation is_a: GO:0050871 ! positive regulation of B cell activation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0042100 ! positively regulates B cell proliferation relationship: RO:0002213 GO:0042100 ! positively regulates B cell proliferation [Term] id: GO:0030900 name: forebrain development namespace: biological_process def: "The process whose specific outcome is the progression of the forebrain over time, from its formation to the mature structure. The forebrain is the anterior of the three primary divisions of the developing chordate brain or the corresponding part of the adult brain (in vertebrates, includes especially the cerebral hemispheres, the thalamus, and the hypothalamus and especially in higher vertebrates is the main control center for sensory and associative information processing, visceral functions, and voluntary motor functions)." [PMID:4975589, PMID:4992177] synonym: "prosencephalon development" EXACT [] is_a: GO:0048856 ! anatomical structure development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0001890 ! results in development of forebrain relationship: BFO:0000050 GO:0007420 ! part of brain development relationship: RO:0002296 UBERON:0001890 ! results in development of forebrain [Term] id: GO:0030901 name: midbrain development namespace: biological_process def: "The process whose specific outcome is the progression of the midbrain over time, from its formation to the mature structure. The midbrain is the middle division of the three primary divisions of the developing chordate brain or the corresponding part of the adult brain (in vertebrates, includes a ventral part containing the cerebral peduncles and a dorsal tectum containing the corpora quadrigemina and that surrounds the aqueduct of Sylvius connecting the third and fourth ventricles)." [PMID:4975589, PMID:4992177] synonym: "mesencephalon development" EXACT [] is_a: GO:0048856 ! anatomical structure development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0001891 ! results in development of midbrain relationship: BFO:0000050 GO:0007420 ! part of brain development relationship: RO:0002162 NCBITaxon:89593 ! in taxon Craniata relationship: RO:0002296 UBERON:0001891 ! results in development of midbrain [Term] id: GO:0030902 name: hindbrain development namespace: biological_process def: "The process whose specific outcome is the progression of the hindbrain over time, from its formation to the mature structure. The hindbrain is the posterior of the three primary divisions of the developing chordate brain, or the corresponding part of the adult brain (in vertebrates, includes the cerebellum, pons, and medulla oblongata and controls the autonomic functions and equilibrium)." [PMID:4975589, PMID:4992177] synonym: "rhombencephalon development" EXACT [] is_a: GO:0048856 ! anatomical structure development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0002028 ! results in development of hindbrain relationship: BFO:0000050 GO:0007420 ! part of brain development relationship: RO:0002296 UBERON:0002028 ! results in development of hindbrain [Term] id: GO:0030903 name: notochord development namespace: biological_process def: "The process whose specific outcome is the progression of the notochord over time, from its formation to the mature structure. The notochord is a mesoderm-derived structure located ventral of the developing nerve cord. In vertebrates, the notochord serves as a core around which other mesodermal cells form the vertebrae. In the most primitive chordates, which lack vertebrae, the notochord persists as a substitute for a vertebral column." [GOC:dgh] is_a: GO:0048568 ! embryonic organ development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0002328 ! results in development of notochord relationship: RO:0002296 UBERON:0002328 ! results in development of notochord [Term] id: GO:0030910 name: olfactory placode formation namespace: biological_process def: "The formation of a thickening of the neural ectoderm in the head region of the vertebrate embryo which develops into the olfactory region of the nasal cavity." [GOC:dgh] is_a: GO:0060788 ! ectodermal placode formation intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0003050 ! results in formation of anatomical entity olfactory placode relationship: BFO:0000050 GO:0043584 ! part of nose development relationship: BFO:0000050 GO:0071699 ! part of olfactory placode morphogenesis relationship: RO:0002297 UBERON:0003050 ! results in formation of anatomical entity olfactory placode [Term] id: GO:0030916 name: otic vesicle formation namespace: biological_process def: "The process resulting in the transition of the otic placode into the otic vesicle, a transient embryonic structure formed during development of the vertebrate inner ear." [GOC:dgh] synonym: "otocyst biosynthesis" EXACT [] synonym: "otocyst formation" EXACT [] is_a: GO:0072175 ! epithelial tube formation intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0003051 ! results in formation of anatomical entity ear vesicle relationship: BFO:0000050 GO:0071600 ! part of otic vesicle morphogenesis relationship: RO:0002297 UBERON:0003051 ! results in formation of anatomical entity ear vesicle [Term] id: GO:0030917 name: midbrain-hindbrain boundary development namespace: biological_process def: "The process whose specific outcome is the progression of the midbrain-hindbrain boundary over time, from its formation to the mature structure. The midbrain-hindbrain domain of the embryonic brain is comprised of the mesencephalic vesicle and the first rhombencephalic vesicle at early somitogenesis stages." [GOC:dgh] synonym: "isthmic organizer development" EXACT [] synonym: "isthmomesencephalic boundary development" EXACT [] synonym: "isthmus development" EXACT [] synonym: "MHB development" EXACT [] synonym: "midbrain-hindbrain orgainizer development" EXACT [] is_a: GO:0048856 ! anatomical structure development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0003052 ! results in development of midbrain-hindbrain boundary relationship: BFO:0000050 GO:0007420 ! part of brain development relationship: BFO:0000050 GO:0021903 ! part of rostrocaudal neural tube patterning relationship: RO:0002296 UBERON:0003052 ! results in development of midbrain-hindbrain boundary [Term] id: GO:0030936 name: transmembrane collagen trimer namespace: cellular_component def: "Any collagen trimer that passes through a lipid bilayer membrane." [PMID:21421911] synonym: "MACIT" EXACT [ISBN:0198599587] is_a: GO:0005581 ! collagen trimer is_a: GO:0098797 ! plasma membrane protein complex intersection_of: GO:0005581 ! collagen trimer intersection_of: BFO:0000050 GO:0005886 ! part of plasma membrane [Term] id: GO:0030951 name: establishment or maintenance of microtubule cytoskeleton polarity namespace: biological_process def: "Any cellular process that results in the specification, formation or maintenance of polarized microtubule-based cytoskeletal structures." [GOC:mah] is_a: GO:0000226 ! microtubule cytoskeleton organization is_a: GO:0030952 ! establishment or maintenance of cytoskeleton polarity [Term] id: GO:0030952 name: establishment or maintenance of cytoskeleton polarity namespace: biological_process def: "Any cellular process that results in the specification, formation or maintenance of polarized cytoskeletal structures." [GOC:mah] synonym: "cytoskeleton polarization" RELATED [] is_a: GO:0007010 ! cytoskeleton organization is_a: GO:0007163 ! establishment or maintenance of cell polarity [Term] id: GO:0030955 name: potassium ion binding namespace: molecular_function def: "Binding to a potassium ion (K+)." [GOC:mah] synonym: "K ion binding" EXACT [] is_a: GO:0031420 ! alkali metal ion binding intersection_of: GO:0005488 ! binding intersection_of: RO:0004009 CHEBI:29103 ! has primary input relationship: RO:0004009 CHEBI:29103 ! has primary input [Term] id: GO:0030990 name: intraciliary transport particle namespace: cellular_component def: "A nonmembrane-bound oligomeric protein complex that participates in bidirectional transport of molecules (cargo) along axonemal microtubules." [GOC:cilia, GOC:kmv, PMID:14570576, PMID:22118932, PMID:23945166] comment: Note that we deem cilia and microtubule-based flagella to be equivalent. subset: goslim_pir synonym: "IFT complex" RELATED [] synonym: "intraflagellar transport complex" EXACT [] synonym: "intraflagellar transport particle" EXACT [] is_a: GO:0032991 ! protein-containing complex relationship: RO:0002216 GO:0035735 ! capable of part of intraciliary transport involved in cilium assembly [Term] id: GO:0031012 name: extracellular matrix namespace: cellular_component def: "A structure lying external to one or more cells, which provides structural support, biochemical or biomechanical cues for cells or tissues." [GOC:BHF, GOC:mah, GOC:rph, PMID:21123617, PMID:28089324, PMID:33605520] subset: goslim_chembl subset: goslim_drosophila subset: goslim_euk_cellular_processes_ribbon subset: goslim_generic subset: goslim_pir subset: goslim_prokaryote synonym: "matrisome" NARROW [] synonym: "proteinaceous extracellular matrix" EXACT [] xref: NIF_Subcellular:nlx_subcell_20090513 xref: Wikipedia:Extracellular_matrix is_a: GO:0030312 ! external encapsulating structure disjoint_from: GO:0032991 ! protein-containing complex disjoint_from: GO:0043226 ! organelle disjoint_from: GO:0044423 ! virion component property_value: skos:prefLabel "extracellular matrix" xsd:string [Term] id: GO:0031016 name: pancreas development namespace: biological_process def: "The process whose specific outcome is the progression of the pancreas over time, from its formation to the mature structure. The pancreas is an endoderm derived structure that produces precursors of digestive enzymes and blood glucose regulating hormones." [GOC:cvs] xref: Wikipedia:Pancreas is_a: GO:0048513 ! animal organ development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0001264 ! results in development of pancreas relationship: RO:0002296 UBERON:0001264 ! results in development of pancreas property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/23777" xsd:anyURI [Term] id: GO:0031017 name: exocrine pancreas development namespace: biological_process def: "The process whose specific outcome is the progression of the exocrine pancreas over time, from its formation to the mature structure. The exocrine pancreas produces and store zymogens of digestive enzymes, such as chymotrypsinogen and trypsinogen in the acinar cells." [GOC:cvs] is_a: GO:0048732 ! gland development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0000017 ! results in development of exocrine pancreas relationship: BFO:0000050 GO:0031016 ! part of pancreas development relationship: BFO:0000050 GO:0035272 ! part of exocrine system development relationship: BFO:0000050 GO:0055123 ! part of digestive system development relationship: RO:0002296 UBERON:0000017 ! results in development of exocrine pancreas [Term] id: GO:0031018 name: endocrine pancreas development namespace: biological_process def: "The process whose specific outcome is the progression of the endocrine pancreas over time, from its formation to the mature structure. The endocrine pancreas is made up of islet cells that produce insulin, glucagon and somatostatin." [GOC:cvs] xref: Reactome:R-HSA-186712 "Regulation of beta-cell development" is_a: GO:0048856 ! anatomical structure development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0000016 ! results in development of endocrine pancreas relationship: BFO:0000050 GO:0031016 ! part of pancreas development relationship: BFO:0000050 GO:0035270 ! part of endocrine system development relationship: RO:0002296 UBERON:0000016 ! results in development of endocrine pancreas [Term] id: GO:0031022 name: nuclear migration along microfilament namespace: biological_process def: "The directed movement of the nucleus along microfilaments within the cell, mediated by motor proteins." [GOC:mah] synonym: "nuclear migration, microfilament-mediated" EXACT [] is_a: GO:0007097 ! nuclear migration is_a: GO:0030048 ! actin filament-based movement is_a: GO:0099515 ! actin filament-based transport intersection_of: GO:0007097 ! nuclear migration intersection_of: RO:0002341 GO:0005884 ! results in transport along actin filament [Term] id: GO:0031023 name: microtubule organizing center organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a microtubule organizing center, a structure from which microtubules grow." [GOC:dph, GOC:jl, GOC:mah] subset: goslim_pir synonym: "microtubule organising center organisation" EXACT [] synonym: "microtubule organizing center organization and biogenesis" RELATED [GOC:mah] is_a: GO:0007017 ! microtubule-based process is_a: GO:0016043 ! cellular component organization intersection_of: GO:0016043 ! cellular component organization intersection_of: RO:0002592 GO:0005815 ! results in organization of microtubule organizing center relationship: BFO:0000050 GO:0000226 ! part of microtubule cytoskeleton organization relationship: RO:0002592 GO:0005815 ! results in organization of microtubule organizing center [Term] id: GO:0031032 name: actomyosin structure organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures containing both actin and myosin or paramyosin. The myosin may be organized into filaments." [GOC:dph, GOC:jl, GOC:mah] comment: Note that this term is a child of 'actin cytoskeleton organization and biogenesis ; GO:0030036' because the actin cytoskeleton is defined as actin filaments and associated proteins. synonym: "actomyosin organization" EXACT [] synonym: "actomyosin structure organisation" EXACT [] synonym: "actomyosin structure organization and biogenesis" RELATED [GOC:mah] is_a: GO:0030036 ! actin cytoskeleton organization intersection_of: GO:0016043 ! cellular component organization intersection_of: RO:0002592 GO:0042641 ! results in organization of actomyosin relationship: RO:0002592 GO:0042641 ! results in organization of actomyosin [Term] id: GO:0031045 name: dense core granule namespace: cellular_component def: "Electron-dense organelle with a granular internal matrix; contains proteins destined to be secreted." [NIF_Subcellular:sao772007592, PMID:14690495] synonym: "dense core vesicle" EXACT syngo_official_label [GOC:kmv] xref: NIF_Subcellular:sao772007592 is_a: GO:0030141 ! secretory granule property_value: RO:0002161 NCBITaxon:4890 [Term] id: GO:0031069 name: hair follicle morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the hair follicle are generated and organized." [GOC:ln] is_a: BFO:0000003 is_a: GO:0009653 ! anatomical structure morphogenesis is_a: GO:0022405 ! hair cycle process intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0002073 ! results in morphogenesis of hair follicle relationship: BFO:0000050 GO:0001942 ! part of hair follicle development relationship: BFO:0000050 GO:0048730 ! part of epidermis morphogenesis relationship: RO:0002298 UBERON:0002073 ! results in morphogenesis of hair follicle [Term] id: GO:0031076 name: embryonic camera-type eye development namespace: biological_process def: "The process occurring during the embryonic phase whose specific outcome is the progression of the eye over time, from its formation to the mature structure." [GOC:mah, GOC:mtg_sensu] synonym: "embryonic eye development" EXACT [] is_a: GO:0043010 ! camera-type eye development is_a: GO:0048568 ! embryonic organ development [Term] id: GO:0031090 name: organelle membrane namespace: cellular_component def: "A membrane that is one of the two lipid bilayers of an organelle envelope or the outermost membrane of single membrane bound organelle." [GOC:dos, GOC:mah] synonym: "intracellular membrane" RELATED [NIF_Subcellular:sao830981606] xref: NIF_Subcellular:sao830981606 is_a: GO:0016020 ! membrane intersection_of: GO:0016020 ! membrane intersection_of: BFO:0000050 GO:0043227 ! part of membrane-bounded organelle relationship: BFO:0000050 GO:0043227 ! part of membrane-bounded organelle [Term] id: GO:0031099 name: regeneration namespace: biological_process def: "The regrowth of a lost or destroyed body part, such as an organ or tissue. This process may occur via renewal, repair, and/or growth alone (i.e. increase in size or mass)." [GOC:mah, GOC:pr] xref: Wikipedia:Regeneration_(biology) is_a: GO:0048856 ! anatomical structure development [Term] id: GO:0031100 name: animal organ regeneration namespace: biological_process def: "The regrowth of a lost or destroyed animal organ." [GOC:mah] is_a: GO:0031099 ! regeneration is_a: GO:0048513 ! animal organ development intersection_of: GO:0031099 ! regeneration intersection_of: RO:0002299 UBERON:0000062 ! results in maturation of organ relationship: RO:0002299 UBERON:0000062 ! results in maturation of organ [Term] id: GO:0031109 name: microtubule polymerization or depolymerization namespace: biological_process def: "Assembly or disassembly of microtubules by the addition or removal of tubulin heterodimers from a microtubule." [GOC:mah] synonym: "microtubule dynamics" EXACT [] is_a: GO:0000226 ! microtubule cytoskeleton organization property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/23195" xsd:anyURI [Term] id: GO:0031110 name: regulation of microtubule polymerization or depolymerization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of microtubule polymerization or depolymerization by the addition or removal of tubulin heterodimers from a microtubule." [GOC:mah] is_a: GO:0070507 ! regulation of microtubule cytoskeleton organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0031109 ! regulates microtubule polymerization or depolymerization relationship: RO:0002211 GO:0031109 ! regulates microtubule polymerization or depolymerization [Term] id: GO:0031111 name: negative regulation of microtubule polymerization or depolymerization namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of microtubule polymerization or depolymerization." [GOC:mah] synonym: "down regulation of microtubule polymerization or depolymerization" EXACT [] synonym: "down-regulation of microtubule polymerization or depolymerization" EXACT [] synonym: "downregulation of microtubule polymerization or depolymerization" EXACT [] synonym: "inhibition of microtubule polymerization or depolymerization" NARROW [] is_a: GO:0031110 ! regulation of microtubule polymerization or depolymerization is_a: GO:0051494 ! negative regulation of cytoskeleton organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0031109 ! negatively regulates microtubule polymerization or depolymerization relationship: RO:0002212 GO:0031109 ! negatively regulates microtubule polymerization or depolymerization [Term] id: GO:0031112 name: positive regulation of microtubule polymerization or depolymerization namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of microtubule polymerization or depolymerization." [GOC:mah] synonym: "activation of microtubule polymerization or depolymerization" NARROW [] synonym: "stimulation of microtubule polymerization or depolymerization" NARROW [] synonym: "up regulation of microtubule polymerization or depolymerization" EXACT [] synonym: "up-regulation of microtubule polymerization or depolymerization" EXACT [] synonym: "upregulation of microtubule polymerization or depolymerization" EXACT [] is_a: GO:0031110 ! regulation of microtubule polymerization or depolymerization is_a: GO:0051495 ! positive regulation of cytoskeleton organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0031109 ! positively regulates microtubule polymerization or depolymerization relationship: RO:0002213 GO:0031109 ! positively regulates microtubule polymerization or depolymerization [Term] id: GO:0031113 name: regulation of microtubule polymerization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of microtubule polymerization." [GOC:mah] is_a: GO:0031110 ! regulation of microtubule polymerization or depolymerization is_a: GO:0032271 ! regulation of protein polymerization is_a: GO:1902903 ! regulation of supramolecular fiber organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0046785 ! regulates microtubule polymerization relationship: RO:0002211 GO:0046785 ! regulates microtubule polymerization [Term] id: GO:0031114 name: regulation of microtubule depolymerization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of microtubule depolymerization." [GOC:mah] synonym: "regulation of microtubule disassembly" EXACT [] is_a: GO:0031110 ! regulation of microtubule polymerization or depolymerization is_a: GO:1901879 ! regulation of protein depolymerization is_a: GO:1902903 ! regulation of supramolecular fiber organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0007019 ! regulates microtubule depolymerization relationship: RO:0002211 GO:0007019 ! regulates microtubule depolymerization [Term] id: GO:0031115 name: negative regulation of microtubule polymerization namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of microtubule polymerization." [GOC:mah] synonym: "down regulation of microtubule polymerization" EXACT [] synonym: "down-regulation of microtubule polymerization" EXACT [] synonym: "downregulation of microtubule polymerization" EXACT [] synonym: "inhibition of microtubule polymerization" NARROW [] is_a: GO:0031111 ! negative regulation of microtubule polymerization or depolymerization is_a: GO:0031113 ! regulation of microtubule polymerization is_a: GO:0032272 ! negative regulation of protein polymerization is_a: GO:1902904 ! negative regulation of supramolecular fiber organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0046785 ! negatively regulates microtubule polymerization relationship: RO:0002212 GO:0046785 ! negatively regulates microtubule polymerization [Term] id: GO:0031116 name: positive regulation of microtubule polymerization namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of microtubule polymerization." [GOC:mah] synonym: "activation of microtubule polymerization" NARROW [] synonym: "stimulation of microtubule polymerization" NARROW [] synonym: "up regulation of microtubule polymerization" EXACT [] synonym: "up-regulation of microtubule polymerization" EXACT [] synonym: "upregulation of microtubule polymerization" EXACT [] is_a: GO:0031112 ! positive regulation of microtubule polymerization or depolymerization is_a: GO:0031113 ! regulation of microtubule polymerization is_a: GO:0032273 ! positive regulation of protein polymerization is_a: GO:1902905 ! positive regulation of supramolecular fiber organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0046785 ! positively regulates microtubule polymerization relationship: RO:0002213 GO:0046785 ! positively regulates microtubule polymerization [Term] id: GO:0031117 name: positive regulation of microtubule depolymerization namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of microtubule depolymerization." [GOC:mah] synonym: "activation of microtubule depolymerization" NARROW [] synonym: "microtubule destabilization" EXACT [] synonym: "positive regulation of microtubule catastrophe" NARROW [GOC:dph, GOC:tb] synonym: "positive regulation of microtubule disassembly" EXACT [] synonym: "stimulation of microtubule depolymerization" NARROW [] synonym: "up regulation of microtubule depolymerization" EXACT [] synonym: "up-regulation of microtubule depolymerization" EXACT [] synonym: "upregulation of microtubule depolymerization" EXACT [] is_a: GO:0031112 ! positive regulation of microtubule polymerization or depolymerization is_a: GO:0031114 ! regulation of microtubule depolymerization is_a: GO:1901881 ! positive regulation of protein depolymerization is_a: GO:1902905 ! positive regulation of supramolecular fiber organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0007019 ! positively regulates microtubule depolymerization relationship: RO:0002213 GO:0007019 ! positively regulates microtubule depolymerization [Term] id: GO:0031122 name: cytoplasmic microtubule organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of structures formed of microtubules and associated proteins in the cytoplasm of a cell." [GOC:mah] synonym: "cytoplasmic microtubule organisation" EXACT [] synonym: "cytoplasmic microtubule organization and biogenesis" RELATED [GOC:mah] is_a: GO:0000226 ! microtubule cytoskeleton organization is_a: GO:0097435 ! supramolecular fiber organization intersection_of: GO:0016043 ! cellular component organization intersection_of: RO:0002592 GO:0005881 ! results in organization of cytoplasmic microtubule relationship: RO:0002592 GO:0005881 ! results in organization of cytoplasmic microtubule [Term] id: GO:0031128 name: developmental induction namespace: biological_process def: "A developmental process involving two tissues in which one tissue (the inducer) produces a signal that directs cell fate commitment of cells in the second tissue (the responder)." [GOC:cjm, GOC:dph, GOC:mah, PMID:24503535] is_a: GO:0032502 ! developmental process intersection_of: GO:0032502 ! developmental process intersection_of: BFO:0000051 GO:0045168 ! has part cell-cell signaling involved in cell fate commitment relationship: BFO:0000051 GO:0045168 ! has part cell-cell signaling involved in cell fate commitment property_value: RO:0002161 NCBITaxon:4895 [Term] id: GO:0031143 name: pseudopodium namespace: cellular_component def: "A temporary protrusion or retractile process of a cell, associated with flowing movements of the protoplasm, and serving for locomotion and feeding." [ISBN:0198506732] subset: goslim_pir synonym: "axopodium" NARROW [] synonym: "lobopodium" NARROW [] synonym: "pseudopod" EXACT [] synonym: "pseudopodial protrusion" EXACT [] synonym: "reticulopodium" NARROW [] xref: Wikipedia:Pseudopod is_a: GO:0120025 ! plasma membrane bounded cell projection property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/21139" xsd:anyURI property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/21141" xsd:anyURI [Term] id: GO:0031175 name: neuron projection development namespace: biological_process def: "The process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites)." [GOC:mah] synonym: "neurite biosynthesis" NARROW [] synonym: "neurite development" NARROW [GOC:dph] synonym: "neurite formation" NARROW [] synonym: "neurite growth" NARROW [] synonym: "neurite outgrowth" NARROW [] is_a: GO:0120036 ! plasma membrane bounded cell projection organization intersection_of: GO:0120036 ! plasma membrane bounded cell projection organization intersection_of: BFO:0000050 GO:0048666 ! part of neuron development relationship: BFO:0000050 GO:0048666 ! part of neuron development [Term] id: GO:0031201 name: SNARE complex namespace: cellular_component def: "A protein complex involved in membrane fusion; a stable ternary complex consisting of a four-helix bundle, usually formed from one R-SNARE and three Q-SNAREs with an ionic layer sandwiched between hydrophobic layers. One well-characterized example is the neuronal SNARE complex formed of synaptobrevin 2, syntaxin 1a, and SNAP-25." [GOC:bhm, GOC:pr, PMID:10872468, PMID:19450911] is_a: GO:0098796 ! membrane protein complex relationship: BFO:0000050 GO:0005737 ! part of cytoplasm relationship: RO:0002216 GO:0006906 ! capable of part of vesicle fusion [Term] id: GO:0031214 name: biomineral tissue development namespace: biological_process def: "Formation of hard tissues that consist mainly of inorganic compounds, and also contain a small amounts of organic matrices that are believed to play important roles in their formation." [PMID:15132736] xref: Wikipedia:Biomineralization is_a: GO:0009888 ! tissue development relationship: BFO:0000050 GO:0048513 ! part of animal organ development property_value: RO:0002161 NCBITaxon:147554 property_value: RO:0002161 NCBITaxon:33630 property_value: RO:0002161 NCBITaxon:33682 property_value: RO:0002161 NCBITaxon:38254 property_value: RO:0002161 NCBITaxon:4891 [Term] id: GO:0031252 name: cell leading edge namespace: cellular_component def: "The area of a motile cell closest to the direction of movement." [GOC:pg] subset: goslim_pir synonym: "front of cell" EXACT [] synonym: "leading edge of cell" EXACT [] is_a: GO:0110165 ! cellular anatomical structure relationship: BFO:0000050 CL:0000000 ! part of cell property_value: RO:0002161 NCBITaxon:4751 [Term] id: GO:0031253 name: cell projection membrane namespace: cellular_component def: "The portion of the plasma membrane surrounding a plasma membrane bounded cell surface projection." [GOC:krc, GOC:mah] synonym: "membrane extension" RELATED [] synonym: "membrane projection" RELATED [] is_a: GO:0098590 ! plasma membrane region intersection_of: GO:0016020 ! membrane intersection_of: RO:0002007 GO:0120025 ! bounding layer of plasma membrane bounded cell projection relationship: RO:0002007 GO:0120025 ! bounding layer of plasma membrane bounded cell projection [Term] id: GO:0031256 name: leading edge membrane namespace: cellular_component def: "The portion of the plasma membrane surrounding the leading edge of a motile cell." [GOC:mah] is_a: GO:0110165 ! cellular anatomical structure relationship: BFO:0000050 GO:0005886 ! part of plasma membrane relationship: BFO:0000050 GO:0031252 ! part of cell leading edge property_value: RO:0002161 NCBITaxon:4751 [Term] id: GO:0031268 name: pseudopodium organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a pseudopodium, a temporary protrusion or retractile process of a cell, associated with cellular movement." [GOC:pg] synonym: "pseudopodium organisation" EXACT [] synonym: "pseudopodium organization and biogenesis" RELATED [GOC:mah] is_a: GO:0120036 ! plasma membrane bounded cell projection organization intersection_of: GO:0016043 ! cellular component organization intersection_of: RO:0002592 GO:0031143 ! results in organization of pseudopodium relationship: RO:0002592 GO:0031143 ! results in organization of pseudopodium [Term] id: GO:0031269 name: pseudopodium assembly namespace: biological_process def: "The assembly of a pseudopodium by rearrangement of the actin cytoskeleton and overlying membrane." [GOC:dph, GOC:mah, GOC:pg, GOC:tb] synonym: "pseudopodium extension" EXACT [] synonym: "pseudopodium formation" RELATED [GOC:dph, GOC:tb] is_a: GO:0031268 ! pseudopodium organization is_a: GO:0120031 ! plasma membrane bounded cell projection assembly intersection_of: GO:0022607 ! cellular component assembly intersection_of: RO:0002588 GO:0031143 ! results in assembly of pseudopodium relationship: RO:0002588 GO:0031143 ! results in assembly of pseudopodium [Term] id: GO:0031270 name: pseudopodium retraction namespace: biological_process def: "The myosin-based contraction and retraction of a pseudopodium." [GOC:pg] is_a: GO:0022411 ! cellular component disassembly is_a: GO:0031268 ! pseudopodium organization intersection_of: GO:0022411 ! cellular component disassembly intersection_of: RO:0002590 GO:0031143 ! results in disassembly of pseudopodium relationship: RO:0002590 GO:0031143 ! results in disassembly of pseudopodium [Term] id: GO:0031272 name: regulation of pseudopodium assembly namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the assembly of pseudopodia." [GOC:pg] synonym: "regulation of pseudopodium formation" RELATED [] is_a: GO:0120032 ! regulation of plasma membrane bounded cell projection assembly intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0031269 ! regulates pseudopodium assembly relationship: RO:0002211 GO:0031269 ! regulates pseudopodium assembly [Term] id: GO:0031273 name: negative regulation of pseudopodium assembly namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the assembly of pseudopodia." [GOC:pg] synonym: "down regulation of pseudopodium formation" RELATED [] synonym: "down-regulation of pseudopodium formation" RELATED [] synonym: "downregulation of pseudopodium formation" RELATED [] synonym: "inhibition of pseudopodium formation" NARROW [] synonym: "negative regulation of pseudopodium formation" RELATED [] is_a: GO:0031272 ! regulation of pseudopodium assembly is_a: GO:0120033 ! negative regulation of plasma membrane bounded cell projection assembly intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0031269 ! negatively regulates pseudopodium assembly relationship: RO:0002212 GO:0031269 ! negatively regulates pseudopodium assembly [Term] id: GO:0031274 name: positive regulation of pseudopodium assembly namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the assembly of pseudopodia." [GOC:pg] synonym: "activation of pseudopodium formation" NARROW [] synonym: "positive regulation of pseudopodium formation" RELATED [GOC:dph] synonym: "stimulation of pseudopodium formation" NARROW [] synonym: "up regulation of pseudopodium formation" RELATED [] synonym: "up-regulation of pseudopodium formation" RELATED [] synonym: "upregulation of pseudopodium formation" RELATED [] is_a: GO:0031272 ! regulation of pseudopodium assembly is_a: GO:0120034 ! positive regulation of plasma membrane bounded cell projection assembly intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0031269 ! positively regulates pseudopodium assembly relationship: RO:0002213 GO:0031269 ! positively regulates pseudopodium assembly [Term] id: GO:0031294 name: lymphocyte costimulation namespace: biological_process def: "The process of providing, via surface-bound receptor-ligand pairs, a second, antigen-independent, signal in addition to that provided by the B- or T cell receptor to augment B- or T cell activation." [ISBN:0781735149] synonym: "lymphocyte co-stimulation" EXACT [] is_a: GO:0002376 ! immune system process is_a: GO:0051251 ! positive regulation of lymphocyte activation [Term] id: GO:0031295 name: T cell costimulation namespace: biological_process def: "The process of providing, via surface-bound receptor-ligand pairs, a second, antigen-independent, signal in addition to that provided by the T cell receptor to augment T cell activation." [ISBN:0781735149] synonym: "T cell co-stimulation" EXACT [] synonym: "T lymphocyte costimulation" EXACT [] synonym: "T-cell co-stimulation" EXACT [] synonym: "T-cell costimulation" EXACT [] synonym: "T-lymphocyte costimulation" EXACT [] xref: Reactome:R-HSA-388841 "Costimulation by the CD28 family" is_a: GO:0031294 ! lymphocyte costimulation is_a: GO:0050870 ! positive regulation of T cell activation intersection_of: GO:0031294 ! lymphocyte costimulation intersection_of: RO:0004009 CL:0000084 ! has primary input T cell relationship: RO:0004009 CL:0000084 ! has primary input T cell [Term] id: GO:0031296 name: B cell costimulation namespace: biological_process def: "The process of providing, via surface-bound receptor-ligand pairs, a second, antigen-independent, signal in addition to that provided by the B cell receptor to augment B cell activation." [ISBN:0781735149] synonym: "B cell co-stimulation" EXACT [] synonym: "B lymphocyte co-stimulation" EXACT [] synonym: "B lymphocyte costimulation" EXACT [] synonym: "B-cell co-stimulation" EXACT [] synonym: "B-cell costimulation" EXACT [] synonym: "B-lymphocyte co-stimulation" EXACT [] synonym: "B-lymphocyte costimulation" EXACT [] is_a: GO:0031294 ! lymphocyte costimulation is_a: GO:0050871 ! positive regulation of B cell activation intersection_of: GO:0031294 ! lymphocyte costimulation intersection_of: RO:0004009 CL:0000236 ! has primary input B cell relationship: RO:0004009 CL:0000236 ! has primary input B cell [Term] id: GO:0031333 name: negative regulation of protein-containing complex assembly namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of protein complex assembly." [GOC:mah] synonym: "down regulation of protein complex assembly" EXACT [] synonym: "down-regulation of protein complex assembly" EXACT [] synonym: "downregulation of protein complex assembly" EXACT [] synonym: "inhibition of protein complex assembly" NARROW [] synonym: "negative regulation of protein complex assembly" RELATED [] is_a: GO:0043254 ! regulation of protein-containing complex assembly is_a: GO:0051129 ! negative regulation of cellular component organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0065003 ! negatively regulates protein-containing complex assembly relationship: RO:0002212 GO:0065003 ! negatively regulates protein-containing complex assembly [Term] id: GO:0031334 name: positive regulation of protein-containing complex assembly namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of protein complex assembly." [GOC:mah] synonym: "activation of protein complex assembly" NARROW [] synonym: "positive regulation of protein complex assembly" RELATED [] synonym: "stimulation of protein complex assembly" NARROW [] synonym: "up regulation of protein complex assembly" EXACT [] synonym: "up-regulation of protein complex assembly" EXACT [] synonym: "upregulation of protein complex assembly" EXACT [] is_a: GO:0043254 ! regulation of protein-containing complex assembly is_a: GO:0044089 ! positive regulation of cellular component biogenesis is_a: GO:0051130 ! positive regulation of cellular component organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0065003 ! positively regulates protein-containing complex assembly relationship: RO:0002213 GO:0065003 ! positively regulates protein-containing complex assembly [Term] id: GO:0031338 name: regulation of vesicle fusion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of vesicle fusion." [GOC:mah] is_a: GO:0033043 ! regulation of organelle organization is_a: GO:0060627 ! regulation of vesicle-mediated transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0006906 ! regulates vesicle fusion relationship: RO:0002211 GO:0006906 ! regulates vesicle fusion [Term] id: GO:0031339 name: negative regulation of vesicle fusion namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of vesicle fusion." [GOC:mah] synonym: "down regulation of vesicle fusion" EXACT [] synonym: "down-regulation of vesicle fusion" EXACT [] synonym: "downregulation of vesicle fusion" EXACT [] synonym: "inhibition of vesicle fusion" NARROW [] is_a: GO:0010639 ! negative regulation of organelle organization is_a: GO:0031338 ! regulation of vesicle fusion is_a: GO:0051051 ! negative regulation of transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0006906 ! negatively regulates vesicle fusion relationship: RO:0002212 GO:0006906 ! negatively regulates vesicle fusion [Term] id: GO:0031340 name: positive regulation of vesicle fusion namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of vesicle fusion." [GOC:mah] synonym: "activation of vesicle fusion" NARROW [] synonym: "stimulation of vesicle fusion" NARROW [] synonym: "up regulation of vesicle fusion" EXACT [] synonym: "up-regulation of vesicle fusion" EXACT [] synonym: "upregulation of vesicle fusion" EXACT [] is_a: GO:0010638 ! positive regulation of organelle organization is_a: GO:0031338 ! regulation of vesicle fusion is_a: GO:0051050 ! positive regulation of transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0006906 ! positively regulates vesicle fusion relationship: RO:0002213 GO:0006906 ! positively regulates vesicle fusion [Term] id: GO:0031341 name: regulation of cell killing namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cell killing, the process in which a cell brings about the death of another cell, either in the same or a different organism." [GOC:mah] is_a: GO:0050794 ! regulation of cellular process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0001906 ! regulates cell killing relationship: RO:0002211 GO:0001906 ! regulates cell killing [Term] id: GO:0031342 name: negative regulation of cell killing namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cell killing." [GOC:mah] synonym: "down regulation of cell killing" EXACT [] synonym: "down-regulation of cell killing" EXACT [] synonym: "downregulation of cell killing" EXACT [] synonym: "inhibition of cell killing" NARROW [] xref: Reactome:R-HSA-9664433 "Leishmania parasite growth and survival" is_a: GO:0031341 ! regulation of cell killing is_a: GO:0048523 ! negative regulation of cellular process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0001906 ! negatively regulates cell killing relationship: RO:0002212 GO:0001906 ! negatively regulates cell killing [Term] id: GO:0031343 name: positive regulation of cell killing namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cell killing." [GOC:mah] synonym: "activation of cell killing" NARROW [] synonym: "stimulation of cell killing" NARROW [] synonym: "up regulation of cell killing" EXACT [] synonym: "up-regulation of cell killing" EXACT [] synonym: "upregulation of cell killing" EXACT [] xref: Reactome:R-HSA-9664420 "Killing mechanisms" is_a: GO:0031341 ! regulation of cell killing is_a: GO:0048522 ! positive regulation of cellular process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0001906 ! positively regulates cell killing relationship: RO:0002213 GO:0001906 ! positively regulates cell killing [Term] id: GO:0031344 name: regulation of cell projection organization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell projections." [GOC:mah] synonym: "regulation of cell projection organisation" EXACT [] synonym: "regulation of cell projection organization and biogenesis" RELATED [GOC:mah] is_a: GO:0051128 ! regulation of cellular component organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0030030 ! regulates cell projection organization relationship: RO:0002211 GO:0030030 ! regulates cell projection organization [Term] id: GO:0031345 name: negative regulation of cell projection organization namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell projections." [GOC:mah] synonym: "down regulation of cell projection organization" EXACT [GOC:mah] synonym: "down-regulation of cell projection organization" EXACT [] synonym: "downregulation of cell projection organization" EXACT [] synonym: "inhibition of cell projection organization" NARROW [] synonym: "negative regulation of cell projection organisation" EXACT [] synonym: "negative regulation of cell projection organization and biogenesis" RELATED [GOC:mah] is_a: GO:0031344 ! regulation of cell projection organization is_a: GO:0051129 ! negative regulation of cellular component organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0030030 ! negatively regulates cell projection organization relationship: RO:0002212 GO:0030030 ! negatively regulates cell projection organization [Term] id: GO:0031346 name: positive regulation of cell projection organization namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the process involved in the formation, arrangement of constituent parts, or disassembly of cell projections." [GOC:mah] synonym: "activation of cell projection organization" NARROW [] synonym: "positive regulation of cell projection organisation" EXACT [] synonym: "positive regulation of cell projection organization and biogenesis" RELATED [GOC:mah] synonym: "stimulation of cell projection organization" NARROW [] synonym: "up regulation of cell projection organization" EXACT [] synonym: "up-regulation of cell projection organization" EXACT [] synonym: "upregulation of cell projection organization" EXACT [] is_a: GO:0031344 ! regulation of cell projection organization is_a: GO:0051130 ! positive regulation of cellular component organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0030030 ! positively regulates cell projection organization relationship: RO:0002213 GO:0030030 ! positively regulates cell projection organization [Term] id: GO:0031347 name: regulation of defense response namespace: biological_process def: "Any process that modulates the frequency, rate or extent of a defense response." [GOC:mah] is_a: GO:0080134 ! regulation of response to stress intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0006952 ! regulates defense response relationship: RO:0002211 GO:0006952 ! regulates defense response [Term] id: GO:0031348 name: negative regulation of defense response namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of a defense response." [GOC:mah] synonym: "down regulation of defense response" EXACT [] synonym: "down-regulation of defense response" EXACT [] synonym: "downregulation of defense response" EXACT [] synonym: "inhibition of defense response" NARROW [] is_a: GO:0031347 ! regulation of defense response is_a: GO:0048585 ! negative regulation of response to stimulus intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0006952 ! negatively regulates defense response relationship: RO:0002212 GO:0006952 ! negatively regulates defense response [Term] id: GO:0031349 name: positive regulation of defense response namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of a defense response." [GOC:mah] synonym: "activation of defense response" NARROW [] synonym: "stimulation of defense response" NARROW [] synonym: "up regulation of defense response" EXACT [] synonym: "up-regulation of defense response" EXACT [] synonym: "upregulation of defense response" EXACT [] is_a: GO:0031347 ! regulation of defense response is_a: GO:0048584 ! positive regulation of response to stimulus intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0006952 ! positively regulates defense response relationship: RO:0002213 GO:0006952 ! positively regulates defense response [Term] id: GO:0031399 name: regulation of protein modification process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the covalent alteration of one or more amino acid residues within a protein." [GOC:mah, GOC:tb] subset: goslim_yeast is_a: GO:0051246 ! regulation of protein metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0036211 ! regulates protein modification process relationship: RO:0002211 GO:0036211 ! regulates protein modification process [Term] id: GO:0031400 name: negative regulation of protein modification process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the covalent alteration of one or more amino acid residues within a protein." [GOC:mah, GOC:tb] subset: gocheck_obsoletion_candidate synonym: "down regulation of protein modification" EXACT [] synonym: "down-regulation of protein modification" EXACT [] synonym: "downregulation of protein modification" EXACT [] synonym: "inhibition of protein modification" NARROW [] is_a: GO:0031399 ! regulation of protein modification process is_a: GO:0051248 ! negative regulation of protein metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0036211 ! negatively regulates protein modification process relationship: RO:0002212 GO:0036211 ! negatively regulates protein modification process [Term] id: GO:0031401 name: positive regulation of protein modification process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the covalent alteration of one or more amino acid residues within a protein." [GOC:mah, GOC:tb] subset: gocheck_obsoletion_candidate synonym: "activation of protein modification" NARROW [] synonym: "stimulation of protein modification" NARROW [] synonym: "up regulation of protein modification" EXACT [] synonym: "up-regulation of protein modification" EXACT [] synonym: "upregulation of protein modification" EXACT [] is_a: GO:0031399 ! regulation of protein modification process is_a: GO:0051247 ! positive regulation of protein metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0036211 ! positively regulates protein modification process relationship: RO:0002213 GO:0036211 ! positively regulates protein modification process [Term] id: GO:0031402 name: sodium ion binding namespace: molecular_function def: "Binding to a sodium ion (Na+)." [GOC:mah] synonym: "Na+ ion binding" EXACT [] is_a: GO:0031420 ! alkali metal ion binding intersection_of: GO:0005488 ! binding intersection_of: RO:0004009 CHEBI:29101 ! has primary input relationship: RO:0004009 CHEBI:29101 ! has primary input [Term] id: GO:0031406 name: carboxylic acid binding namespace: molecular_function def: "Binding to a carboxylic acid, an organic acid containing one or more carboxyl (COOH) groups or anions (COO-)." [GOC:mah, ISBN:0198506732] subset: goslim_pir is_a: GO:0043168 ! anion binding is_a: GO:0043177 ! organic acid binding intersection_of: GO:0005488 ! binding intersection_of: RO:0004009 CHEBI:29067 ! has primary input relationship: RO:0004009 CHEBI:29067 ! has primary input [Term] id: GO:0031409 name: pigment binding namespace: molecular_function def: "Binding to a pigment, a general or particular coloring matter in living organisms, e.g. melanin." [GOC:mah] subset: goslim_pir is_a: GO:0005488 ! binding [Term] id: GO:0031410 name: cytoplasmic vesicle namespace: cellular_component def: "A vesicle found in the cytoplasm of a cell." [GOC:ai, GOC:mah, GOC:vesicles] subset: goslim_agr subset: goslim_candida subset: goslim_chembl subset: goslim_generic subset: goslim_mouse subset: goslim_yeast synonym: "cytoplasmic membrane bounded vesicle" RELATED [] synonym: "cytoplasmic membrane-enclosed vesicle" RELATED [] synonym: "cytoplasmic, membrane-bounded vesicle" RELATED [] xref: NIF_Subcellular:sao180601769 is_a: GO:0097708 ! intracellular vesicle intersection_of: GO:0031982 ! vesicle intersection_of: BFO:0000050 GO:0005737 ! part of cytoplasm relationship: BFO:0000050 GO:0005737 ! part of cytoplasm [Term] id: GO:0031420 name: alkali metal ion binding namespace: molecular_function def: "Binding to an alkali metal ion; alkali metals are those elements in group Ia of the periodic table, with the exception of hydrogen." [GOC:mah] is_a: GO:0046872 ! metal ion binding intersection_of: GO:0005488 ! binding intersection_of: RO:0004009 CHEBI:33504 ! has primary input relationship: RO:0004009 CHEBI:33504 ! has primary input [Term] id: GO:0031424 name: keratinization namespace: biological_process def: "The process in which the cytoplasm of the outermost cells of the vertebrate epidermis is replaced by keratin. Keratinization occurs in the stratum corneum, feathers, hair, claws, nails, hooves, and horns." [GOC:dph, GOC:ebc, GOC:sdb_2009, GOC:tb] xref: Reactome:R-HSA-6805567 "Keratinization" is_a: BFO:0000003 is_a: GO:0032501 ! multicellular organismal process relationship: BFO:0000050 GO:0030216 ! part of keratinocyte differentiation relationship: BFO:0000066 CL:0000362 ! occurs in epidermal cell [Term] id: GO:0031445 name: regulation of heterochromatin formation namespace: biological_process def: "Any process that modulates the frequency, rate, extent or location of heterochromatin formation." [GOC:mah] synonym: "regulation of heterochromatin assembly" EXACT [] is_a: GO:0010468 ! regulation of gene expression is_a: GO:0120261 ! regulation of heterochromatin organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0031507 ! regulates heterochromatin formation relationship: RO:0002211 GO:0031507 ! regulates heterochromatin formation property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/23553" xsd:anyURI [Term] id: GO:0031452 name: negative regulation of heterochromatin formation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of heterochromatin formation." [PMID:16855380] synonym: "chromatin decompaction" EXACT [] synonym: "chromatin decondensation" EXACT [PMID:16855380] synonym: "down regulation of heterochromatin formation" EXACT [] synonym: "down-regulation of heterochromatin formation" EXACT [] synonym: "downregulation of heterochromatin formation" EXACT [] synonym: "inhibition of heterochromatin formation" NARROW [] synonym: "negative regulation of heterochromatin assembly" EXACT [] is_a: GO:0010628 ! positive regulation of gene expression is_a: GO:0031445 ! regulation of heterochromatin formation is_a: GO:0120262 ! negative regulation of heterochromatin organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0031507 ! negatively regulates heterochromatin formation relationship: RO:0002212 GO:0031507 ! negatively regulates heterochromatin formation property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/23553" xsd:anyURI [Term] id: GO:0031453 name: positive regulation of heterochromatin formation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of heterochromatin formation." [GOC:mah] synonym: "activation of heterochromatin formation" NARROW [] synonym: "positive regulation of heterochromatin assembly" EXACT [] synonym: "stimulation of heterochromatin formation" NARROW [] synonym: "up regulation of heterochromatin formation" EXACT [] synonym: "up-regulation of heterochromatin formation" EXACT [] synonym: "upregulation of heterochromatin formation" EXACT [] is_a: GO:0031445 ! regulation of heterochromatin formation is_a: GO:0044089 ! positive regulation of cellular component biogenesis is_a: GO:0120263 ! positive regulation of heterochromatin organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0031507 ! positively regulates heterochromatin formation relationship: RO:0002213 GO:0031507 ! positively regulates heterochromatin formation property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/23553" xsd:anyURI [Term] id: GO:0031503 name: protein-containing complex localization namespace: biological_process def: "A localization process that acts on a protein complex; the complex is transported to, or maintained in, a specific location." [GOC:mah] synonym: "cellular protein complex localisation" RELATED [GOC:mah] synonym: "cellular protein complex localization" RELATED [] synonym: "cellular protein-containing complex localization" RELATED [] synonym: "establishment and maintenance of cellular protein complex localization" RELATED [] synonym: "establishment and maintenance of protein complex localization" EXACT [] synonym: "protein complex localisation" EXACT [GOC:mah] synonym: "protein complex localization" RELATED [] is_a: BFO:0000003 is_a: GO:0033036 ! macromolecule localization intersection_of: GO:0033036 ! macromolecule localization intersection_of: RO:0004009 GO:0032991 ! has primary input protein-containing complex relationship: RO:0004009 GO:0032991 ! has primary input protein-containing complex property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/22021" xsd:anyURI [Term] id: GO:0031507 name: heterochromatin formation namespace: biological_process def: "An epigenetic gene silencing mechanism in which chromatin is compacted into heterochromatin, resulting in a chromatin conformation refractory to transcription. This process starts with heterochromatin nucleation, its spreading, and ends with heterochromatin boundary formation." [PMID:25192661, PMID:33827924] synonym: "chromatin silencing" EXACT [] synonym: "chromatin-mediated silencing" EXACT [] synonym: "establishment of chromatin silencing" RELATED [] synonym: "establishment of heterochromatic silencing" RELATED [] synonym: "establishment of heterochromatin architecture" EXACT [GOC:mah] synonym: "establishment of heterochromatin architecture involved in chromatin silencing at centromere outer repeat region" NARROW [GOC:TermGenie] synonym: "establishment of heterochromatin architecture involved in chromatin silencing at pericentric region" NARROW [GOC:TermGenie] synonym: "heterochromatic silencing" RELATED [] synonym: "heterochromatin assembly" EXACT [] synonym: "heterochromatin assembly involved in chromatin silencing" RELATED [] synonym: "heterochromatin assembly involved in chromatin silencing at centromere outer repeat region" NARROW [] synonym: "heterochromatin assembly involved in chromatin silencing at pericentric region" NARROW [GOC:TermGenie] synonym: "heterochromatin formation involved in chromatin silencing" RELATED [] synonym: "heterochromatin formation involved in chromatin silencing at centromere outer repeat region" NARROW [GOC:TermGenie] synonym: "heterochromatin formation involved in chromatin silencing at pericentric region" NARROW [GOC:TermGenie] synonym: "heterochromatin maintenance" BROAD [] synonym: "TGS" BROAD [] synonym: "transcriptional gene silencing" RELATED [] xref: Reactome:R-HSA-5334118 "DNA methylation" is_a: GO:0022607 ! cellular component assembly is_a: GO:0045814 ! negative regulation of gene expression, epigenetic is_a: GO:0070828 ! heterochromatin organization intersection_of: GO:0006325 ! chromatin organization intersection_of: RO:0002588 GO:0000792 ! results in assembly of heterochromatin relationship: RO:0002230 GO:0033696 ! ends with heterochromatin boundary formation relationship: RO:0002588 GO:0000792 ! results in assembly of heterochromatin property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/18954" xsd:anyURI property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/19112" xsd:anyURI property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/22030" xsd:anyURI property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/23553" xsd:anyURI property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/26702" xsd:anyURI [Term] id: GO:0031514 name: motile cilium namespace: cellular_component def: "A cilium which may have a variable arrangement of axonemal microtubules and also contains molecular motors. It may beat with a whip-like pattern that promotes cell motility or transport of fluids and other cells across a cell surface, such as on epithelial cells that line the lumenal ducts of various tissues; or they may display a distinct twirling motion that directs fluid flow asymmetrically across the cellular surface to affect asymmetric body plan organization. Motile cilia can be found in single as well as multiple copies per cell." [GOC:cilia, GOC:dgh, GOC:kmv, PMID:17009929, PMID:20144998, PMID:22118931] synonym: "microtubule-based flagellum" RELATED [] synonym: "motile cilia" EXACT [] synonym: "motile primary cilia" RELATED [] synonym: "motile primary cilium" RELATED [] synonym: "motile secondary cilium" RELATED [] synonym: "nodal cilium" RELATED [] is_a: GO:0005929 ! cilium intersection_of: GO:0005929 ! cilium intersection_of: RO:0002215 GO:0003341 ! capable of cilium movement relationship: RO:0002215 GO:0003341 ! capable of cilium movement property_value: RO:0002161 NCBITaxon:3176 property_value: RO:0002161 NCBITaxon:3378 property_value: RO:0002161 NCBITaxon:3398 property_value: RO:0002161 NCBITaxon:4890 property_value: RO:0002161 NCBITaxon:5782 [Term] id: GO:0031594 name: neuromuscular junction namespace: cellular_component def: "The junction between the axon of a motor neuron and a muscle fiber. In response to the arrival of action potentials, the presynaptic button releases molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane of the muscle fiber, leading to a change in post-synaptic potential." [GOC:nln] comment: In vertebrates, the term 'neuromuscular junction' is limited to synapses targeting skeletal muscle fibers - all of which are cholinergic and excitatory. Both inhibitory and excitatory neuromuscular junctions exist in invertebrates, utilizing a range of neurotransmitters including glutamate, GABA and 5-HT. synonym: "motor endplate" RELATED [NIF_Subcellular:nlx_subcell_20090512] synonym: "NMJ" RELATED [GOC:ha] xref: NIF_Subcellular:sao1124888485 xref: Wikipedia:Neuromuscular_junction is_a: GO:0045202 ! synapse intersection_of: GO:0045202 ! synapse intersection_of: RO:0002131 CL:0000100 ! overlaps motor neuron intersection_of: RO:0002131 CL:0000187 ! overlaps muscle cell relationship: RO:0002131 CL:0000100 ! overlaps motor neuron relationship: RO:0002131 CL:0000187 ! overlaps muscle cell [Term] id: GO:0031641 name: regulation of myelination namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the formation of a myelin sheath around nerve axons." [GOC:mah] is_a: GO:0050794 ! regulation of cellular process is_a: GO:0051960 ! regulation of nervous system development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0042552 ! regulates myelination relationship: RO:0002211 GO:0042552 ! regulates myelination [Term] id: GO:0031642 name: negative regulation of myelination namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the formation of a myelin sheath around nerve axons." [GOC:mah] synonym: "down regulation of myelination" EXACT [] synonym: "down-regulation of myelination" EXACT [] synonym: "downregulation of myelination" EXACT [] synonym: "inhibition of myelination" NARROW [] is_a: GO:0031641 ! regulation of myelination is_a: GO:0031645 ! negative regulation of nervous system process is_a: GO:0048523 ! negative regulation of cellular process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0042552 ! negatively regulates myelination relationship: RO:0002212 GO:0042552 ! negatively regulates myelination [Term] id: GO:0031643 name: positive regulation of myelination namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the formation of a myelin sheath around nerve axons." [GOC:mah] synonym: "activation of myelination" NARROW [] synonym: "stimulation of myelination" NARROW [] synonym: "up regulation of myelination" EXACT [] synonym: "up-regulation of myelination" EXACT [] synonym: "upregulation of myelination" EXACT [] is_a: GO:0031641 ! regulation of myelination is_a: GO:0031646 ! positive regulation of nervous system process is_a: GO:0048522 ! positive regulation of cellular process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0042552 ! positively regulates myelination relationship: RO:0002213 GO:0042552 ! positively regulates myelination [Term] id: GO:0031644 name: regulation of nervous system process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of a neurophysiological process, an organ system process carried out by any of the organs or tissues of the nervous system." [GOC:dph, GOC:mah, GOC:tb] synonym: "regulation of neurological process" EXACT [GOC:dph, GOC:tb] synonym: "regulation of neurological system process" EXACT [] synonym: "regulation of neurophysiological process" EXACT [] is_a: GO:0044057 ! regulation of system process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0050877 ! regulates nervous system process relationship: RO:0002211 GO:0050877 ! regulates nervous system process [Term] id: GO:0031645 name: negative regulation of nervous system process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of a neurophysiological process." [GOC:dph, GOC:mah, GOC:tb] synonym: "down regulation of neurological process" EXACT [] synonym: "down-regulation of neurological process" EXACT [] synonym: "downregulation of neurological process" EXACT [] synonym: "inhibition of neurological process" NARROW [] synonym: "negative regulation of neurological process" EXACT [GOC:dph, GOC:tb] synonym: "negative regulation of neurological system process" EXACT [] synonym: "negative regulation of neurophysiological process" EXACT [] is_a: GO:0031644 ! regulation of nervous system process is_a: GO:0051241 ! negative regulation of multicellular organismal process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0050877 ! negatively regulates nervous system process relationship: RO:0002212 GO:0050877 ! negatively regulates nervous system process [Term] id: GO:0031646 name: positive regulation of nervous system process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of a neurophysiological process." [GOC:dph, GOC:mah, GOC:tb] synonym: "activation of neurological process" NARROW [] synonym: "positive regulation of neurological process" EXACT [GOC:dph, GOC:tb] synonym: "positive regulation of neurological system process" EXACT [] synonym: "positive regulation of neurophysiological process" EXACT [] synonym: "stimulation of neurological process" NARROW [] synonym: "up regulation of neurological process" EXACT [] synonym: "up-regulation of neurological process" EXACT [] synonym: "upregulation of neurological process" EXACT [] is_a: GO:0031644 ! regulation of nervous system process is_a: GO:0051240 ! positive regulation of multicellular organismal process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0050877 ! positively regulates nervous system process relationship: RO:0002213 GO:0050877 ! positively regulates nervous system process [Term] id: GO:0031723 name: CXCR4 chemokine receptor binding namespace: molecular_function def: "Binding to a CXCR4 chemokine receptor." [GOC:mah, GOC:nln] synonym: "CXCR4 chemokine receptor ligand" NARROW [] synonym: "stromal cell-derived factor 1 receptor binding" EXACT [] is_a: GO:0045236 ! CXCR chemokine receptor binding intersection_of: GO:0005488 ! binding intersection_of: RO:0004009 PR:000001208 ! has primary input C-X-C chemokine receptor type 4 relationship: RO:0004009 PR:000001208 ! has primary input C-X-C chemokine receptor type 4 [Term] id: GO:0031727 name: CCR2 chemokine receptor binding namespace: molecular_function def: "Binding to a CCR2 chemokine receptor." [GOC:mah, GOC:nln] synonym: "CCR2 chemokine receptor ligand" NARROW [] synonym: "monocyte chemoattractant protein 1 receptor binding" EXACT [] is_a: GO:0048020 ! CCR chemokine receptor binding intersection_of: GO:0005488 ! binding intersection_of: RO:0004009 PR:000001199 ! has primary input C-C chemokine receptor type 2 relationship: RO:0004009 PR:000001199 ! has primary input C-C chemokine receptor type 2 [Term] id: GO:0031728 name: CCR3 chemokine receptor binding namespace: molecular_function def: "Binding to a CCR3 chemokine receptor." [GOC:mah, GOC:nln] synonym: "CCR3 chemokine receptor ligand" NARROW [] synonym: "eosinophil eotaxin receptor binding" EXACT [] is_a: GO:0048020 ! CCR chemokine receptor binding intersection_of: GO:0005488 ! binding intersection_of: RO:0004009 PR:000001255 ! has primary input C-C chemokine receptor type 3 relationship: RO:0004009 PR:000001255 ! has primary input C-C chemokine receptor type 3 [Term] id: GO:0031731 name: CCR6 chemokine receptor binding namespace: molecular_function def: "Binding to a CCR6 chemokine receptor." [GOC:mah, GOC:nln] synonym: "CCR6 chemokine receptor ligand" NARROW [] synonym: "LARC receptor binding" EXACT [] is_a: GO:0048020 ! CCR chemokine receptor binding intersection_of: GO:0005488 ! binding intersection_of: RO:0004009 PR:000001202 ! has primary input C-C chemokine receptor type 6 relationship: RO:0004009 PR:000001202 ! has primary input C-C chemokine receptor type 6 [Term] id: GO:0031732 name: CCR7 chemokine receptor binding namespace: molecular_function def: "Binding to a CCR7 chemokine receptor." [GOC:mah, GOC:nln] synonym: "CCR7 chemokine receptor ligand" NARROW [] synonym: "MIP-3 beta receptor binding" EXACT [] synonym: "type 1 EBV-induced G-protein coupled receptor binding" EXACT [] is_a: GO:0048020 ! CCR chemokine receptor binding intersection_of: GO:0005488 ! binding intersection_of: RO:0004009 PR:000001203 ! has primary input C-C chemokine receptor type 7 relationship: RO:0004009 PR:000001203 ! has primary input C-C chemokine receptor type 7 [Term] id: GO:0031737 name: CX3C chemokine receptor binding namespace: molecular_function def: "Binding to a CX3C chemokine receptor." [GOC:mah, GOC:nln] synonym: "CX3C chemokine receptor ligand" NARROW [] synonym: "fractalkine receptor binding" EXACT [] is_a: GO:0042379 ! chemokine receptor binding intersection_of: GO:0005488 ! binding intersection_of: RO:0004009 PR:000001206 ! has primary input CX3C chemokine receptor 1 relationship: RO:0004009 PR:000001206 ! has primary input CX3C chemokine receptor 1 [Term] id: GO:0031761 name: fMet-Leu-Phe receptor binding namespace: molecular_function def: "Binding to a fMet-Leu-Phe receptor." [GOC:mah, GOC:nln] synonym: "fMet-Leu-Phe receptor ligand" NARROW [] synonym: "N-formyl peptide receptor binding" EXACT [] is_a: GO:0001664 ! G protein-coupled receptor binding intersection_of: GO:0005488 ! binding intersection_of: RO:0004009 PR:000001431 ! has primary input N-formyl peptide receptor relationship: RO:0004009 PR:000001431 ! has primary input N-formyl peptide receptor [Term] id: GO:0031855 name: oxytocin receptor binding namespace: molecular_function def: "Binding to an oxytocin receptor." [GOC:mah, GOC:nln] synonym: "oxytocin receptor ligand" NARROW [] is_a: GO:0001664 ! G protein-coupled receptor binding intersection_of: GO:0005488 ! binding intersection_of: RO:0004009 PR:000001635 ! has primary input oxytocin receptor relationship: RO:0004009 PR:000001635 ! has primary input oxytocin receptor [Term] id: GO:0031862 name: prostanoid receptor binding namespace: molecular_function def: "Binding to a prostanoid receptor." [GOC:mah, GOC:nln] synonym: "prostanoid receptor ligand" NARROW [] is_a: GO:0001664 ! G protein-coupled receptor binding intersection_of: GO:0005488 ! binding intersection_of: RO:0004009 PR:000001549 ! has primary input prostanoid receptor relationship: RO:0004009 PR:000001549 ! has primary input prostanoid receptor [Term] id: GO:0031943 name: regulation of glucocorticoid metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving glucocorticoids." [GOC:mah] synonym: "regulation of glucocorticoid metabolism" EXACT [] is_a: GO:0019218 ! regulation of steroid metabolic process is_a: GO:0032350 ! regulation of hormone metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0008211 ! regulates glucocorticoid metabolic process relationship: RO:0002211 GO:0008211 ! regulates glucocorticoid metabolic process property_value: RO:0002161 NCBITaxon:4895 [Term] id: GO:0031946 name: regulation of glucocorticoid biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of glucocorticoids." [GOC:mah] is_a: GO:0031943 ! regulation of glucocorticoid metabolic process is_a: GO:0090030 ! regulation of steroid hormone biosynthetic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0006704 ! regulates glucocorticoid biosynthetic process relationship: RO:0002211 GO:0006704 ! regulates glucocorticoid biosynthetic process property_value: RO:0002161 NCBITaxon:4895 [Term] id: GO:0031947 name: negative regulation of glucocorticoid biosynthetic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of glucocorticoids." [GOC:mah] synonym: "down regulation of glucocorticoid biosynthetic process" EXACT [] synonym: "down-regulation of glucocorticoid biosynthetic process" EXACT [] synonym: "downregulation of glucocorticoid biosynthetic process" EXACT [] synonym: "inhibition of glucocorticoid biosynthetic process" NARROW [] is_a: GO:0031946 ! regulation of glucocorticoid biosynthetic process is_a: GO:0090032 ! negative regulation of steroid hormone biosynthetic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0006704 ! negatively regulates glucocorticoid biosynthetic process relationship: RO:0002212 GO:0006704 ! negatively regulates glucocorticoid biosynthetic process property_value: RO:0002161 NCBITaxon:4895 [Term] id: GO:0031948 name: positive regulation of glucocorticoid biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of glucocorticoids." [GOC:mah] synonym: "activation of glucocorticoid biosynthetic process" NARROW [] synonym: "stimulation of glucocorticoid biosynthetic process" NARROW [] synonym: "up regulation of glucocorticoid biosynthetic process" EXACT [] synonym: "up-regulation of glucocorticoid biosynthetic process" EXACT [] synonym: "upregulation of glucocorticoid biosynthetic process" EXACT [] is_a: GO:0031946 ! regulation of glucocorticoid biosynthetic process is_a: GO:0090031 ! positive regulation of steroid hormone biosynthetic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0006704 ! positively regulates glucocorticoid biosynthetic process relationship: RO:0002213 GO:0006704 ! positively regulates glucocorticoid biosynthetic process property_value: RO:0002161 NCBITaxon:4895 [Term] id: GO:0031949 name: regulation of glucocorticoid catabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of glucocorticoids." [GOC:mah] is_a: GO:0031943 ! regulation of glucocorticoid metabolic process is_a: GO:0050994 ! regulation of lipid catabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0006713 ! regulates glucocorticoid catabolic process relationship: RO:0002211 GO:0006713 ! regulates glucocorticoid catabolic process property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/29024" xsd:anyURI property_value: RO:0002161 NCBITaxon:4895 [Term] id: GO:0031950 name: negative regulation of glucocorticoid catabolic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of glucocorticoids." [GOC:mah] synonym: "down regulation of glucocorticoid catabolic process" EXACT [] synonym: "down-regulation of glucocorticoid catabolic process" EXACT [] synonym: "downregulation of glucocorticoid catabolic process" EXACT [] synonym: "inhibition of glucocorticoid catabolic process" NARROW [] is_a: GO:0031949 ! regulation of glucocorticoid catabolic process is_a: GO:0045939 ! negative regulation of steroid metabolic process is_a: GO:0050995 ! negative regulation of lipid catabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0006713 ! negatively regulates glucocorticoid catabolic process relationship: RO:0002212 GO:0006713 ! negatively regulates glucocorticoid catabolic process property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/29024" xsd:anyURI property_value: RO:0002161 NCBITaxon:4895 [Term] id: GO:0031951 name: positive regulation of glucocorticoid catabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of glucocorticoids." [GOC:mah] synonym: "activation of glucocorticoid catabolic process" NARROW [] synonym: "stimulation of glucocorticoid catabolic process" NARROW [] synonym: "up regulation of glucocorticoid catabolic process" EXACT [] synonym: "up-regulation of glucocorticoid catabolic process" EXACT [] synonym: "upregulation of glucocorticoid catabolic process" EXACT [] is_a: GO:0031949 ! regulation of glucocorticoid catabolic process is_a: GO:0045940 ! positive regulation of steroid metabolic process is_a: GO:0050996 ! positive regulation of lipid catabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0006713 ! positively regulates glucocorticoid catabolic process relationship: RO:0002213 GO:0006713 ! positively regulates glucocorticoid catabolic process property_value: RO:0002161 NCBITaxon:4895 [Term] id: GO:0031960 name: response to corticosteroid namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a corticosteroid hormone stimulus. A corticosteroid is a steroid hormone that is produced in the adrenal cortex. Corticosteroids are involved in a wide range of physiologic systems such as stress response, immune response and regulation of inflammation, carbohydrate metabolism, protein catabolism, blood electrolyte levels, and behavior. They include glucocorticoids and mineralocorticoids." [GOC:mah, PMID:11027914] synonym: "response to corticosteroid stimulus" EXACT [GOC:dos] is_a: GO:0048545 ! response to steroid hormone intersection_of: GO:0050896 ! response to stimulus intersection_of: RO:0004009 CHEBI:50858 ! has primary input relationship: RO:0004009 CHEBI:50858 ! has primary input property_value: RO:0002161 NCBITaxon:4751 [Term] id: GO:0031965 name: nuclear membrane namespace: cellular_component def: "Either of the lipid bilayers that surround the nucleus and form the nuclear envelope; excludes the intermembrane space." [GOC:mah, GOC:pz] xref: NIF_Subcellular:sao1687101204 is_a: GO:0031090 ! organelle membrane intersection_of: GO:0016020 ! membrane intersection_of: BFO:0000050 GO:0005634 ! part of nucleus relationship: BFO:0000050 GO:0005635 ! part of nuclear envelope [Term] id: GO:0031966 name: mitochondrial membrane namespace: cellular_component def: "Either of the lipid bilayers that surround the mitochondrion and form the mitochondrial envelope." [GOC:mah, NIF_Subcellular:sao1045389829] xref: NIF_Subcellular:sao1045389829 is_a: GO:0031090 ! organelle membrane intersection_of: GO:0016020 ! membrane intersection_of: BFO:0000050 GO:0005739 ! part of mitochondrion relationship: BFO:0000050 GO:0005740 ! part of mitochondrial envelope [Term] id: GO:0031967 name: organelle envelope namespace: cellular_component def: "A double membrane structure enclosing an organelle, including two lipid bilayers and the region between them. In some cases, an organelle envelope may have more than two membranes." [GOC:mah, GOC:pz] subset: goslim_mouse is_a: GO:0110165 ! cellular anatomical structure relationship: BFO:0000050 GO:0043227 ! part of membrane-bounded organelle relationship: BFO:0000050 GO:0043229 ! part of intracellular organelle [Term] id: GO:0031968 name: organelle outer membrane namespace: cellular_component def: "The outer, i.e. cytoplasm-facing in a cellular organelle, lipid bilayer of an organelle envelope." [GOC:mah] is_a: GO:0019867 ! outer membrane is_a: GO:0098588 ! bounding membrane of organelle intersection_of: GO:0016020 ! membrane intersection_of: BFO:0000050 GO:0031967 ! part of organelle envelope intersection_of: RO:0002007 GO:0043226 ! bounding layer of organelle relationship: BFO:0000050 GO:0031967 ! part of organelle envelope [Term] id: GO:0031969 name: chloroplast membrane namespace: cellular_component def: "Either of the lipid bilayers that surround a chloroplast and form the chloroplast envelope." [GOC:mah, GOC:pz] xref: Wikipedia:Chloroplast_membrane is_a: GO:0042170 ! plastid membrane relationship: BFO:0000050 GO:0009941 ! part of chloroplast envelope property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:28009 property_value: RO:0002161 NCBITaxon:33208 property_value: RO:0002161 NCBITaxon:4751 property_value: RO:0002161 NCBITaxon:554915 [Term] id: GO:0031974 name: membrane-enclosed lumen namespace: cellular_component def: "The enclosed volume within a sealed membrane or between two sealed membranes. Encompasses the volume enclosed by the membranes of a particular organelle, e.g. endoplasmic reticulum lumen, or the space between the two lipid bilayers of a double membrane surrounding an organelle, e.g. nuclear envelope lumen." [GOC:add, GOC:mah] is_a: GO:0110165 ! cellular anatomical structure disjoint_from: GO:0045202 ! synapse property_value: skos:prefLabel "membrane-enclosed lumen" xsd:string [Term] id: GO:0031981 name: nuclear lumen namespace: cellular_component def: "The volume enclosed by the nuclear inner membrane." [GOC:mah, GOC:pz] is_a: GO:0070013 ! intracellular organelle lumen relationship: BFO:0000050 GO:0005634 ! part of nucleus property_value: skos:prefLabel "nuclear lumen" xsd:string [Term] id: GO:0031982 name: vesicle namespace: cellular_component def: "Any small, fluid-filled, spherical organelle enclosed by membrane." [GOC:mah, GOC:pz, GOC:vesicles] subset: goslim_pir synonym: "membrane-bounded vesicle" RELATED [] synonym: "membrane-enclosed vesicle" RELATED [] xref: NIF_Subcellular:sao221389602 xref: Wikipedia:Vesicle_(biology) is_a: GO:0043227 ! membrane-bounded organelle [Term] id: GO:0031987 name: locomotion involved in locomotory behavior namespace: biological_process def: "Self-propelled movement of a cell or organism from one location to another in a behavioral context; the aspect of locomotory behavior having to do with movement." [GOC:mah] synonym: "locomotion during locomotory behaviour" EXACT [] is_a: GO:0040011 ! locomotion intersection_of: GO:0040011 ! locomotion intersection_of: BFO:0000050 GO:0007626 ! part of locomotory behavior relationship: BFO:0000050 GO:0007626 ! part of locomotory behavior [Term] id: GO:0032024 name: positive regulation of insulin secretion namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the regulated release of insulin." [GOC:mah] synonym: "activation of insulin secretion" NARROW [] synonym: "stimulation of insulin secretion" NARROW [] synonym: "up regulation of insulin secretion" EXACT [] synonym: "up-regulation of insulin secretion" EXACT [] synonym: "upregulation of insulin secretion" EXACT [] xref: Reactome:R-HSA-399997 "Acetylcholine regulates insulin secretion" is_a: GO:0050714 ! positive regulation of protein secretion is_a: GO:0050796 ! regulation of insulin secretion is_a: GO:0090277 ! positive regulation of peptide hormone secretion intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0030073 ! positively regulates insulin secretion relationship: RO:0002213 GO:0030073 ! positively regulates insulin secretion [Term] id: GO:0032042 name: mitochondrial DNA metabolic process namespace: biological_process def: "The chemical reactions and pathways involving mitochondrial DNA." [GOC:mah] synonym: "mitochondrial DNA metabolism" EXACT [] synonym: "mtDNA metabolic process" EXACT [] synonym: "mtDNA metabolism" EXACT [] is_a: GO:0006259 ! DNA metabolic process intersection_of: GO:0006259 ! DNA metabolic process intersection_of: BFO:0000066 GO:0005739 ! occurs in mitochondrion relationship: BFO:0000066 GO:0005739 ! occurs in mitochondrion relationship: RO:0002162 NCBITaxon:2759 ! in taxon Eukaryota [Term] id: GO:0032043 name: mitochondrial DNA catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of mitochondrial DNA." [GOC:mah] synonym: "mitochondrial DNA breakdown" EXACT [] synonym: "mitochondrial DNA catabolism" EXACT [] synonym: "mitochondrial DNA degradation" EXACT [] synonym: "mtDNA breakdown" EXACT [] synonym: "mtDNA catabolic process" EXACT [] synonym: "mtDNA catabolism" EXACT [] synonym: "mtDNA degradation" EXACT [] is_a: GO:0006308 ! DNA catabolic process is_a: GO:0032042 ! mitochondrial DNA metabolic process intersection_of: GO:0006308 ! DNA catabolic process intersection_of: BFO:0000066 GO:0005739 ! occurs in mitochondrion [Term] id: GO:0032052 name: bile acid binding namespace: molecular_function def: "Binding to a bile acid, a steroid carboxylic acids occurring in bile." [GOC:rph] xref: Reactome:R-HSA-8873850 "STARD5 binds DCA, LCA" is_a: GO:0033293 ! monocarboxylic acid binding intersection_of: GO:0005488 ! binding intersection_of: RO:0004009 CHEBI:36235 ! has primary input relationship: RO:0004009 CHEBI:36235 ! has primary input [Term] id: GO:0032053 name: ciliary basal body organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a ciliary basal body, a short cylindrical array of microtubules and associated proteins found at the base of a eukaryotic cilium (also called flagellum)." [GOC:cilia, GOC:dph, GOC:jl, GOC:krc, GOC:mah, PMID:9889124] synonym: "microtubule basal body organisation" BROAD [GOC:mah] synonym: "microtubule basal body organization" BROAD [] synonym: "microtubule basal body organization and biogenesis" RELATED [GOC:mah] is_a: GO:0031023 ! microtubule organizing center organization is_a: GO:0044782 ! cilium organization intersection_of: GO:0016043 ! cellular component organization intersection_of: RO:0002592 GO:0036064 ! results in organization of ciliary basal body relationship: RO:0002592 GO:0036064 ! results in organization of ciliary basal body [Term] id: GO:0032055 name: negative regulation of translation in response to stress namespace: biological_process def: "Any process that stops, prevents or reduces the rate of translation as a result of a stimulus indicating the organism is under stress." [GOC:mah] synonym: "down regulation of translation in response to stress" EXACT [] synonym: "down-regulation of translation in response to stress" EXACT [] synonym: "downregulation of translation in response to stress" EXACT [] synonym: "inhibition of translation in response to stress" NARROW [] is_a: GO:0017148 ! negative regulation of translation is_a: GO:0043555 ! regulation of translation in response to stress intersection_of: GO:0065007 ! biological regulation intersection_of: BFO:0000050 GO:0033554 ! part of cellular response to stress intersection_of: RO:0002212 GO:0006412 ! negatively regulates translation [Term] id: GO:0032056 name: positive regulation of translation in response to stress namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of translation as a result of a stimulus indicating the organism is under stress." [GOC:mah] synonym: "activation of translation in response to stress" NARROW [] synonym: "stimulation of translation in response to stress" NARROW [] synonym: "up regulation of translation in response to stress" EXACT [] synonym: "up-regulation of translation in response to stress" EXACT [] synonym: "upregulation of translation in response to stress" EXACT [] is_a: GO:0043555 ! regulation of translation in response to stress is_a: GO:0045727 ! positive regulation of translation intersection_of: GO:0065007 ! biological regulation intersection_of: BFO:0000050 GO:0033554 ! part of cellular response to stress intersection_of: RO:0002213 GO:0006412 ! positively regulates translation [Term] id: GO:0032057 name: negative regulation of translational initiation in response to stress namespace: biological_process def: "Any process that stops, prevents or reduces the rate of translation initiation as a result of a stimulus indicating the organism is under stress." [GOC:mah] synonym: "down regulation of translation initiation in response to stress" EXACT [] synonym: "down-regulation of translation initiation in response to stress" EXACT [] synonym: "downregulation of translation initiation in response to stress" EXACT [] synonym: "inhibition of translation initiation in response to stress" NARROW [] is_a: GO:0045947 ! negative regulation of translational initiation intersection_of: GO:0065007 ! biological regulation intersection_of: BFO:0000050 GO:0006950 ! part of response to stress intersection_of: RO:0002212 GO:0006413 ! negatively regulates translational initiation relationship: BFO:0000050 GO:0006950 ! part of response to stress [Term] id: GO:0032058 name: positive regulation of translational initiation in response to stress namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of translation initiation as a result of a stimulus indicating the organism is under stress." [GOC:mah] synonym: "activation of translation initiation in response to stress" NARROW [] synonym: "stimulation of translation initiation in response to stress" NARROW [] synonym: "up regulation of translation initiation in response to stress" EXACT [] synonym: "up-regulation of translation initiation in response to stress" EXACT [] synonym: "upregulation of translation initiation in response to stress" EXACT [] is_a: GO:0045948 ! positive regulation of translational initiation intersection_of: GO:0065007 ! biological regulation intersection_of: BFO:0000050 GO:0006950 ! part of response to stress intersection_of: RO:0002213 GO:0006413 ! positively regulates translational initiation relationship: BFO:0000050 GO:0006950 ! part of response to stress [Term] id: GO:0032059 name: bleb namespace: cellular_component def: "A cell extension caused by localized decoupling of the cytoskeleton from the plasma membrane and characterized by rapid formation, rounded shape, and scarcity of organelles within the protrusion. Blebs are formed during apoptosis and other cellular processes, including cell locomotion, cell division, and as a result of physical or chemical stresses." [GOC:mtg_apoptosis, PMID:12083798, PMID:16624291, Wikipedia:Bleb_(cell_biology)] subset: goslim_pir synonym: "plasma membrane bleb" EXACT [GOC:pr] xref: Wikipedia:Bleb_(cell_biology) is_a: GO:0120025 ! plasma membrane bounded cell projection [Term] id: GO:0032060 name: bleb assembly namespace: biological_process def: "The assembly of a bleb, a cell extension caused by localized decoupling of the cytoskeleton from the plasma membrane and characterized by rapid formation, rounded shape, and scarcity of organelles within the protrusion. Plasma membrane blebbing occurs during apoptosis and other cellular processes, including cell locomotion, cell division, and as a result of physical or chemical stresses." [GOC:mah, GOC:mtg_apoptosis, PMID:12083798, PMID:16624291, Wikipedia:Bleb_(cell_biology)] synonym: "blebbing" BROAD [GOC:pr] synonym: "cell blebbing" EXACT [] synonym: "membrane blebbing" BROAD [GOC:pr] synonym: "plasma membrane bleb assembly" EXACT [GOC:pr] synonym: "plasma membrane blebbing" EXACT [GOC:pr] is_a: GO:0120031 ! plasma membrane bounded cell projection assembly intersection_of: GO:0022607 ! cellular component assembly intersection_of: RO:0002588 GO:0032059 ! results in assembly of bleb relationship: RO:0002588 GO:0032059 ! results in assembly of bleb [Term] id: GO:0032065 name: maintenance of protein location in cell cortex namespace: biological_process def: "A process in which a protein or protein complex is maintained in a specific location in the cell cortex." [GOC:vw] synonym: "cortical protein anchoring" RELATED [] is_a: GO:0032507 ! maintenance of protein location in cell intersection_of: GO:0045185 ! maintenance of protein location intersection_of: BFO:0000066 GO:0005938 ! occurs in cell cortex relationship: BFO:0000066 GO:0005938 ! occurs in cell cortex [Term] id: GO:0032077 name: positive regulation of deoxyribonuclease activity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of deoxyribonuclease activity, the hydrolysis of ester linkages within deoxyribonucleic acid." [GOC:mah] subset: gocheck_obsoletion_candidate synonym: "activation of deoxyribonuclease activity" NARROW [] synonym: "deoxyribonuclease activator" RELATED [] synonym: "DNase activator" RELATED [] synonym: "stimulation of deoxyribonuclease activity" NARROW [] synonym: "up regulation of deoxyribonuclease activity" EXACT [] synonym: "up-regulation of deoxyribonuclease activity" EXACT [] synonym: "upregulation of deoxyribonuclease activity" EXACT [] is_a: GO:0043085 ! positive regulation of catalytic activity is_a: GO:0051054 ! positive regulation of DNA metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0004536 ! positively regulates DNA nuclease activity relationship: RO:0002213 GO:0004536 ! positively regulates DNA nuclease activity [Term] id: GO:0032091 name: negative regulation of protein binding namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of protein binding." [GOC:mah] subset: gocheck_do_not_annotate synonym: "down regulation of protein binding" EXACT [] synonym: "down-regulation of protein binding" EXACT [] synonym: "downregulation of protein binding" EXACT [] synonym: "inhibition of protein binding" NARROW [] is_a: GO:0043393 ! regulation of protein binding is_a: GO:0051100 ! negative regulation of binding intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0005515 ! negatively regulates protein binding relationship: RO:0002212 GO:0005515 ! negatively regulates protein binding [Term] id: GO:0032092 name: positive regulation of protein binding namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of protein binding." [GOC:mah] subset: gocheck_do_not_annotate synonym: "activation of protein binding" NARROW [] synonym: "stimulation of protein binding" NARROW [] synonym: "up regulation of protein binding" EXACT [] synonym: "up-regulation of protein binding" EXACT [] synonym: "upregulation of protein binding" EXACT [] is_a: GO:0043393 ! regulation of protein binding is_a: GO:0051099 ! positive regulation of binding intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0005515 ! positively regulates protein binding relationship: RO:0002213 GO:0005515 ! positively regulates protein binding [Term] id: GO:0032101 name: regulation of response to external stimulus namespace: biological_process def: "Any process that modulates the frequency, rate or extent of a response to an external stimulus." [GOC:mah] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_annotate is_a: GO:0048583 ! regulation of response to stimulus intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0009605 ! regulates response to external stimulus relationship: RO:0002211 GO:0009605 ! regulates response to external stimulus [Term] id: GO:0032102 name: negative regulation of response to external stimulus namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of a response to an external stimulus." [GOC:mah] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_annotate synonym: "down regulation of response to external stimulus" EXACT [] synonym: "down-regulation of response to external stimulus" EXACT [] synonym: "downregulation of response to external stimulus" EXACT [] synonym: "inhibition of response to external stimulus" NARROW [] is_a: GO:0032101 ! regulation of response to external stimulus is_a: GO:0048585 ! negative regulation of response to stimulus intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0009605 ! negatively regulates response to external stimulus relationship: RO:0002212 GO:0009605 ! negatively regulates response to external stimulus [Term] id: GO:0032103 name: positive regulation of response to external stimulus namespace: biological_process def: "Any process that activates, maintains or increases the rate of a response to an external stimulus." [GOC:mah] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_annotate synonym: "activation of response to external stimulus" NARROW [] synonym: "stimulation of response to external stimulus" NARROW [] synonym: "up regulation of response to external stimulus" EXACT [] synonym: "up-regulation of response to external stimulus" EXACT [] synonym: "upregulation of response to external stimulus" EXACT [] is_a: GO:0032101 ! regulation of response to external stimulus is_a: GO:0048584 ! positive regulation of response to stimulus intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0009605 ! positively regulates response to external stimulus relationship: RO:0002213 GO:0009605 ! positively regulates response to external stimulus [Term] id: GO:0032127 name: dense core granule membrane namespace: cellular_component def: "The lipid bilayer surrounding a dense core granule." [GOC:mah] synonym: "dense core vesicle membrane" EXACT [GOC:kmv] is_a: GO:0030667 ! secretory granule membrane intersection_of: GO:0016020 ! membrane intersection_of: RO:0002007 GO:0031045 ! bounding layer of dense core granule relationship: RO:0002007 GO:0031045 ! bounding layer of dense core granule property_value: RO:0002161 NCBITaxon:4890 [Term] id: GO:0032222 name: regulation of synaptic transmission, cholinergic namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cholinergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter acetylcholine." [GOC:mah] is_a: GO:0050804 ! modulation of chemical synaptic transmission intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0007271 ! regulates synaptic transmission, cholinergic relationship: RO:0002211 GO:0007271 ! regulates synaptic transmission, cholinergic [Term] id: GO:0032223 name: negative regulation of synaptic transmission, cholinergic namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cholinergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter acetylcholine." [GOC:mah] synonym: "down regulation of synaptic transmission, cholinergic" EXACT [] synonym: "down-regulation of synaptic transmission, cholinergic" EXACT [] synonym: "downregulation of synaptic transmission, cholinergic" EXACT [] synonym: "inhibition of synaptic transmission, cholinergic" NARROW [] is_a: GO:0032222 ! regulation of synaptic transmission, cholinergic is_a: GO:0050805 ! negative regulation of synaptic transmission intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0007271 ! negatively regulates synaptic transmission, cholinergic relationship: RO:0002212 GO:0007271 ! negatively regulates synaptic transmission, cholinergic [Term] id: GO:0032224 name: positive regulation of synaptic transmission, cholinergic namespace: biological_process def: "Any process that activates, maintains or increases the frequency, rate or extent of cholinergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter acetylcholine." [GOC:mah] synonym: "activation of synaptic transmission, cholinergic" NARROW [] synonym: "stimulation of synaptic transmission, cholinergic" NARROW [] synonym: "up regulation of synaptic transmission, cholinergic" EXACT [] synonym: "up-regulation of synaptic transmission, cholinergic" EXACT [] synonym: "upregulation of synaptic transmission, cholinergic" EXACT [] is_a: GO:0032222 ! regulation of synaptic transmission, cholinergic is_a: GO:0050806 ! positive regulation of synaptic transmission intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0007271 ! positively regulates synaptic transmission, cholinergic relationship: RO:0002213 GO:0007271 ! positively regulates synaptic transmission, cholinergic [Term] id: GO:0032225 name: regulation of synaptic transmission, dopaminergic namespace: biological_process def: "Any process that modulates the frequency, rate or extent of dopaminergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter dopamine." [GOC:mah] is_a: GO:0050804 ! modulation of chemical synaptic transmission intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0001963 ! regulates synaptic transmission, dopaminergic relationship: RO:0002211 GO:0001963 ! regulates synaptic transmission, dopaminergic [Term] id: GO:0032226 name: positive regulation of synaptic transmission, dopaminergic namespace: biological_process def: "Any process that activates, maintains or increases the frequency, rate or extent of dopaminergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter dopamine." [GOC:mah] synonym: "activation of synaptic transmission, dopaminergic" NARROW [] synonym: "stimulation of synaptic transmission, dopaminergic" NARROW [] synonym: "up regulation of synaptic transmission, dopaminergic" EXACT [] synonym: "up-regulation of synaptic transmission, dopaminergic" EXACT [] synonym: "upregulation of synaptic transmission, dopaminergic" EXACT [] is_a: GO:0032225 ! regulation of synaptic transmission, dopaminergic is_a: GO:0050806 ! positive regulation of synaptic transmission intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0001963 ! positively regulates synaptic transmission, dopaminergic relationship: RO:0002213 GO:0001963 ! positively regulates synaptic transmission, dopaminergic [Term] id: GO:0032227 name: negative regulation of synaptic transmission, dopaminergic namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of dopaminergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter dopamine." [GOC:mah] synonym: "down regulation of synaptic transmission, dopaminergic" EXACT [] synonym: "down-regulation of synaptic transmission, dopaminergic" EXACT [] synonym: "downregulation of synaptic transmission, dopaminergic" EXACT [] synonym: "inhibition of synaptic transmission, dopaminergic" NARROW [] is_a: GO:0032225 ! regulation of synaptic transmission, dopaminergic is_a: GO:0050805 ! negative regulation of synaptic transmission intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0001963 ! negatively regulates synaptic transmission, dopaminergic relationship: RO:0002212 GO:0001963 ! negatively regulates synaptic transmission, dopaminergic [Term] id: GO:0032228 name: regulation of synaptic transmission, GABAergic namespace: biological_process def: "Any process that modulates the frequency, rate or extent of GABAergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter gamma-aminobutyric acid (GABA)." [GOC:mah] is_a: GO:0050804 ! modulation of chemical synaptic transmission intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0051932 ! regulates synaptic transmission, GABAergic relationship: RO:0002211 GO:0051932 ! regulates synaptic transmission, GABAergic [Term] id: GO:0032229 name: negative regulation of synaptic transmission, GABAergic namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of GABAergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter gamma-aminobutyric acid (GABA)." [GOC:mah] synonym: "down regulation of synaptic transmission, GABAergic" EXACT [] synonym: "down-regulation of synaptic transmission, GABAergic" EXACT [] synonym: "downregulation of synaptic transmission, GABAergic" EXACT [] synonym: "inhibition of synaptic transmission, GABAergic" NARROW [] is_a: GO:0032228 ! regulation of synaptic transmission, GABAergic is_a: GO:0050805 ! negative regulation of synaptic transmission intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0051932 ! negatively regulates synaptic transmission, GABAergic relationship: RO:0002212 GO:0051932 ! negatively regulates synaptic transmission, GABAergic [Term] id: GO:0032230 name: positive regulation of synaptic transmission, GABAergic namespace: biological_process def: "Any process that activates, maintains or increases the frequency, rate or extent of GABAergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter gamma-aminobutyric acid (GABA)." [GOC:mah] synonym: "activation of synaptic transmission, GABAergic" NARROW [] synonym: "stimulation of synaptic transmission, GABAergic" NARROW [] synonym: "up regulation of synaptic transmission, GABAergic" EXACT [] synonym: "up-regulation of synaptic transmission, GABAergic" EXACT [] synonym: "upregulation of synaptic transmission, GABAergic" EXACT [] is_a: GO:0032228 ! regulation of synaptic transmission, GABAergic is_a: GO:0050806 ! positive regulation of synaptic transmission intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0051932 ! positively regulates synaptic transmission, GABAergic relationship: RO:0002213 GO:0051932 ! positively regulates synaptic transmission, GABAergic [Term] id: GO:0032231 name: regulation of actin filament bundle assembly namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the assembly of actin filament bundles." [GOC:mah] synonym: "regulation of actin cable assembly" EXACT [GOC:dph, GOC:tb] synonym: "regulation of actin filament bundle formation" RELATED [GOC:dph] is_a: GO:0044087 ! regulation of cellular component biogenesis is_a: GO:0110053 ! regulation of actin filament organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0051017 ! regulates actin filament bundle assembly relationship: RO:0002211 GO:0051017 ! regulates actin filament bundle assembly [Term] id: GO:0032232 name: negative regulation of actin filament bundle assembly namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the assembly of actin filament bundles." [GOC:mah] synonym: "down regulation of actin filament bundle formation" EXACT [] synonym: "down-regulation of actin filament bundle formation" EXACT [] synonym: "downregulation of actin filament bundle formation" EXACT [] synonym: "inhibition of actin filament bundle formation" NARROW [] is_a: GO:0032231 ! regulation of actin filament bundle assembly is_a: GO:0051494 ! negative regulation of cytoskeleton organization is_a: GO:1902904 ! negative regulation of supramolecular fiber organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0051017 ! negatively regulates actin filament bundle assembly relationship: RO:0002212 GO:0051017 ! negatively regulates actin filament bundle assembly [Term] id: GO:0032233 name: positive regulation of actin filament bundle assembly namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the assembly of actin filament bundles." [GOC:mah] synonym: "activation of actin filament bundle formation" NARROW [] synonym: "stimulation of actin filament bundle formation" NARROW [] synonym: "up regulation of actin filament bundle formation" EXACT [] synonym: "up-regulation of actin filament bundle formation" EXACT [] synonym: "upregulation of actin filament bundle formation" EXACT [] is_a: GO:0032231 ! regulation of actin filament bundle assembly is_a: GO:0044089 ! positive regulation of cellular component biogenesis is_a: GO:0051495 ! positive regulation of cytoskeleton organization is_a: GO:1902905 ! positive regulation of supramolecular fiber organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0051017 ! positively regulates actin filament bundle assembly relationship: RO:0002213 GO:0051017 ! positively regulates actin filament bundle assembly [Term] id: GO:0032239 name: regulation of nucleobase-containing compound transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the directed movement of nucleobases, nucleosides, nucleotides and nucleic acids, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah] synonym: "regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport" RELATED [GOC:dph, GOC:tb] is_a: GO:0051049 ! regulation of transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0015931 ! regulates nucleobase-containing compound transport relationship: RO:0002211 GO:0015931 ! regulates nucleobase-containing compound transport [Term] id: GO:0032240 name: negative regulation of nucleobase-containing compound transport namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of nucleobases, nucleosides, nucleotides and nucleic acids, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah] synonym: "down regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport" EXACT [] synonym: "down-regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport" EXACT [] synonym: "downregulation of nucleobase, nucleoside, nucleotide and nucleic acid transport" EXACT [] synonym: "inhibition of nucleobase, nucleoside, nucleotide and nucleic acid transport" NARROW [] synonym: "negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport" RELATED [GOC:dph, GOC:tb] is_a: GO:0032239 ! regulation of nucleobase-containing compound transport is_a: GO:0051051 ! negative regulation of transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0015931 ! negatively regulates nucleobase-containing compound transport relationship: RO:0002212 GO:0015931 ! negatively regulates nucleobase-containing compound transport [Term] id: GO:0032241 name: positive regulation of nucleobase-containing compound transport namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the directed movement of nucleobases, nucleosides, nucleotides and nucleic acids, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah] synonym: "activation of nucleobase, nucleoside, nucleotide and nucleic acid transport" NARROW [] synonym: "positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport" RELATED [GOC:dph, GOC:tb] synonym: "stimulation of nucleobase, nucleoside, nucleotide and nucleic acid transport" NARROW [] synonym: "up regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport" EXACT [] synonym: "up-regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport" EXACT [] synonym: "upregulation of nucleobase, nucleoside, nucleotide and nucleic acid transport" EXACT [] is_a: GO:0032239 ! regulation of nucleobase-containing compound transport is_a: GO:0051050 ! positive regulation of transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0015931 ! positively regulates nucleobase-containing compound transport relationship: RO:0002213 GO:0015931 ! positively regulates nucleobase-containing compound transport [Term] id: GO:0032252 name: secretory granule localization namespace: biological_process def: "Any process in which a secretory granule is transported to, and/or maintained in, a specific location within the cell." [GOC:mah] synonym: "secretory granule clustering" RELATED [] synonym: "secretory granule localisation" EXACT [GOC:mah] is_a: GO:0051648 ! vesicle localization intersection_of: GO:0051179 ! localization intersection_of: RO:0004009 GO:0030141 ! has primary input secretory granule relationship: RO:0004009 GO:0030141 ! has primary input secretory granule [Term] id: GO:0032253 name: dense core granule localization namespace: biological_process def: "Any process in which a dense core granule is transported to, and/or maintained in, a specific location within the cell." [GOC:mah] synonym: "dense core granule clustering" RELATED [] synonym: "dense core granule localisation" EXACT [GOC:mah] synonym: "dense core vesicle localization" EXACT [GOC:kmv] is_a: GO:0032252 ! secretory granule localization intersection_of: GO:0051179 ! localization intersection_of: RO:0004009 GO:0031045 ! has primary input dense core granule relationship: RO:0004009 GO:0031045 ! has primary input dense core granule [Term] id: GO:0032271 name: regulation of protein polymerization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the process of creating protein polymers." [GOC:mah] synonym: "regulation of protein polymerisation" EXACT [] is_a: GO:0043254 ! regulation of protein-containing complex assembly intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0051258 ! regulates protein polymerization relationship: RO:0002211 GO:0051258 ! regulates protein polymerization [Term] id: GO:0032272 name: negative regulation of protein polymerization namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the process of creating protein polymers." [GOC:mah] synonym: "down regulation of protein polymerization" EXACT [] synonym: "down-regulation of protein polymerization" EXACT [] synonym: "downregulation of protein polymerization" EXACT [] synonym: "inhibition of protein polymerization" NARROW [] is_a: GO:0031333 ! negative regulation of protein-containing complex assembly is_a: GO:0032271 ! regulation of protein polymerization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0051258 ! negatively regulates protein polymerization relationship: RO:0002212 GO:0051258 ! negatively regulates protein polymerization [Term] id: GO:0032273 name: positive regulation of protein polymerization namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the process of creating protein polymers." [GOC:mah] synonym: "activation of protein polymerization" NARROW [] synonym: "stimulation of protein polymerization" NARROW [] synonym: "up regulation of protein polymerization" EXACT [] synonym: "up-regulation of protein polymerization" EXACT [] synonym: "upregulation of protein polymerization" EXACT [] is_a: GO:0031334 ! positive regulation of protein-containing complex assembly is_a: GO:0032271 ! regulation of protein polymerization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0051258 ! positively regulates protein polymerization relationship: RO:0002213 GO:0051258 ! positively regulates protein polymerization [Term] id: GO:0032274 name: gonadotropin secretion namespace: biological_process def: "The regulated release of a gonadotropin, any hormone that stimulates the gonads, especially follicle-stimulating hormone and luteinizing hormone." [GOC:mah, ISBN:0721662544] synonym: "gonadotrophin secretion" EXACT [] is_a: GO:0060986 ! endocrine hormone secretion property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0032275 name: luteinizing hormone secretion namespace: biological_process def: "The regulated release of luteinizing hormone, a gonadotropic glycoprotein hormone secreted by the anterior pituitary." [ISBN:0198506732] is_a: GO:0032274 ! gonadotropin secretion property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0032276 name: regulation of gonadotropin secretion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the regulated release of a gonadotropin." [GOC:mah] synonym: "regulation of gonadotrophin secretion" EXACT [] is_a: GO:0044060 ! regulation of endocrine process is_a: GO:0046883 ! regulation of hormone secretion intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0032274 ! regulates gonadotropin secretion relationship: RO:0002211 GO:0032274 ! regulates gonadotropin secretion property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0032277 name: negative regulation of gonadotropin secretion namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of a gonadotropin." [GOC:mah] synonym: "down regulation of gonadotropin secretion" EXACT [] synonym: "down-regulation of gonadotropin secretion" EXACT [] synonym: "downregulation of gonadotropin secretion" EXACT [] synonym: "inhibition of gonadotropin secretion" NARROW [] synonym: "negative regulation of gonadotrophin secretion" EXACT [GOC:dph] is_a: GO:0032276 ! regulation of gonadotropin secretion is_a: GO:0046888 ! negative regulation of hormone secretion is_a: GO:0051241 ! negative regulation of multicellular organismal process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0032274 ! negatively regulates gonadotropin secretion relationship: RO:0002212 GO:0032274 ! negatively regulates gonadotropin secretion property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0032278 name: positive regulation of gonadotropin secretion namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the regulated release of a gonadotropin." [GOC:mah] synonym: "activation of gonadotropin secretion" NARROW [] synonym: "positive regulation of gonadotrophin secretion" EXACT [GOC:dph] synonym: "stimulation of gonadotropin secretion" NARROW [] synonym: "up regulation of gonadotropin secretion" EXACT [] synonym: "up-regulation of gonadotropin secretion" EXACT [] synonym: "upregulation of gonadotropin secretion" EXACT [] is_a: GO:0032276 ! regulation of gonadotropin secretion is_a: GO:0046887 ! positive regulation of hormone secretion is_a: GO:0051240 ! positive regulation of multicellular organismal process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0032274 ! positively regulates gonadotropin secretion relationship: RO:0002213 GO:0032274 ! positively regulates gonadotropin secretion property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0032288 name: myelin assembly namespace: biological_process def: "The process in which the wraps of cell membrane that constitute myelin are laid down around an axon in the central or peripheral nervous system." [GOC:dgh, GOC:dph, GOC:tb] synonym: "myelin formation" RELATED [GOC:dph, GOC:tb] synonym: "myelin sheath assembly" EXACT [] is_a: GO:0010927 ! cellular component assembly involved in morphogenesis intersection_of: GO:0022607 ! cellular component assembly intersection_of: RO:0002588 GO:0043209 ! results in assembly of myelin sheath relationship: BFO:0000050 GO:0042552 ! part of myelination relationship: RO:0002588 GO:0043209 ! results in assembly of myelin sheath [Term] id: GO:0032289 name: central nervous system myelin formation namespace: biological_process def: "The process in which the wraps of cell membrane that constitute myelin are laid down around an axon by an oligodendrocyte in the central nervous system." [GOC:dgh] synonym: "central nervous system myelin sheath formation" EXACT [] synonym: "myelin formation in central nervous system" EXACT [] is_a: GO:0032288 ! myelin assembly intersection_of: GO:0032288 ! myelin assembly intersection_of: BFO:0000066 UBERON:0001017 ! occurs in central nervous system relationship: BFO:0000050 GO:0022010 ! part of central nervous system myelination [Term] id: GO:0032290 name: peripheral nervous system myelin formation namespace: biological_process def: "The process in which the wraps of cell membrane that constitute myelin are laid down around an axon by Schwann cells in the peripheral nervous system." [GOC:dgh] synonym: "myelin formation in peripheral nervous system" EXACT [] synonym: "peripheral nervous system myelin sheath formation" EXACT [] is_a: GO:0032288 ! myelin assembly intersection_of: GO:0032288 ! myelin assembly intersection_of: BFO:0000066 UBERON:0000010 ! occurs in peripheral nervous system relationship: BFO:0000050 GO:0022011 ! part of myelination in peripheral nervous system property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/19106" xsd:anyURI [Term] id: GO:0032291 name: axon ensheathment in central nervous system namespace: biological_process def: "The process in which a glial cell membrane closes around an axon in the central nervous system. This can be a myelinating or a non-myelinating neuron-glial interaction." [GOC:dgh] synonym: "ensheathment of axons in central nervous system" EXACT [] is_a: GO:0008366 ! axon ensheathment intersection_of: GO:0008366 ! axon ensheathment intersection_of: BFO:0000066 UBERON:0001017 ! occurs in central nervous system relationship: BFO:0000066 UBERON:0001017 ! occurs in central nervous system relationship: RO:0002162 NCBITaxon:33213 ! in taxon Bilateria [Term] id: GO:0032292 name: peripheral nervous system axon ensheathment namespace: biological_process def: "The process in which a Schwann cell membrane closes around an axon in the peripheral nervous system. This can be a myelinating or a non-myelinating neuron-glial interaction." [GOC:dgh] synonym: "ensheathment of axons in peripheral nervous system" EXACT [] is_a: GO:0008366 ! axon ensheathment intersection_of: GO:0008366 ! axon ensheathment intersection_of: BFO:0000066 UBERON:0000010 ! occurs in peripheral nervous system relationship: BFO:0000066 UBERON:0000010 ! occurs in peripheral nervous system [Term] id: GO:0032330 name: regulation of chondrocyte differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of chondrocyte differentiation." [GOC:mah] is_a: GO:0045595 ! regulation of cell differentiation is_a: GO:0061035 ! regulation of cartilage development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0002062 ! regulates chondrocyte differentiation relationship: RO:0002211 GO:0002062 ! regulates chondrocyte differentiation [Term] id: GO:0032331 name: negative regulation of chondrocyte differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of chondrocyte differentiation." [GOC:mah] synonym: "down regulation of chondrocyte differentiation" EXACT [] synonym: "down-regulation of chondrocyte differentiation" EXACT [] synonym: "downregulation of chondrocyte differentiation" EXACT [] synonym: "inhibition of chondrocyte differentiation" NARROW [] is_a: GO:0032330 ! regulation of chondrocyte differentiation is_a: GO:0045596 ! negative regulation of cell differentiation is_a: GO:0061037 ! negative regulation of cartilage development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0002062 ! negatively regulates chondrocyte differentiation relationship: RO:0002212 GO:0002062 ! negatively regulates chondrocyte differentiation [Term] id: GO:0032332 name: positive regulation of chondrocyte differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of chondrocyte differentiation." [GOC:mah] synonym: "activation of chondrocyte differentiation" NARROW [] synonym: "stimulation of chondrocyte differentiation" NARROW [] synonym: "up regulation of chondrocyte differentiation" EXACT [] synonym: "up-regulation of chondrocyte differentiation" EXACT [] synonym: "upregulation of chondrocyte differentiation" EXACT [] is_a: GO:0032330 ! regulation of chondrocyte differentiation is_a: GO:0045597 ! positive regulation of cell differentiation is_a: GO:0061036 ! positive regulation of cartilage development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0002062 ! positively regulates chondrocyte differentiation relationship: RO:0002213 GO:0002062 ! positively regulates chondrocyte differentiation [Term] id: GO:0032341 name: aldosterone metabolic process namespace: biological_process def: "The chemical reactions and pathways involving aldosterone, a corticosteroid hormone that is produced by the zona glomerulosa of the adrenal cortex and regulates salt (sodium and potassium) and water balance." [PMID:16527843] synonym: "aldosterone metabolism" EXACT [] is_a: GO:0006081 ! aldehyde metabolic process is_a: GO:0008207 ! C21-steroid hormone metabolic process is_a: GO:0008212 ! mineralocorticoid metabolic process is_a: GO:0034308 ! primary alcohol metabolic process is_a: GO:0042180 ! ketone metabolic process is_a: GO:0120254 ! olefinic compound metabolic process intersection_of: GO:0008152 ! metabolic process intersection_of: RO:0004007 CHEBI:27584 ! has primary input or output relationship: RO:0004007 CHEBI:27584 ! has primary input or output property_value: RO:0002161 NCBITaxon:4895 [Term] id: GO:0032342 name: aldosterone biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of aldosterone, a corticosteroid hormone that is produced by the zona glomerulosa of the adrenal cortex and regulates salt (sodium and potassium) and water balance." [PMID:16527843] is_a: GO:0006700 ! C21-steroid hormone biosynthetic process is_a: GO:0006705 ! mineralocorticoid biosynthetic process is_a: GO:0032341 ! aldosterone metabolic process is_a: GO:0034309 ! primary alcohol biosynthetic process is_a: GO:0042181 ! ketone biosynthetic process is_a: GO:0046184 ! aldehyde biosynthetic process is_a: GO:0120255 ! olefinic compound biosynthetic process intersection_of: GO:0009058 ! biosynthetic process intersection_of: RO:0004008 CHEBI:27584 ! has primary output relationship: RO:0004008 CHEBI:27584 ! has primary output property_value: RO:0002161 NCBITaxon:4895 [Term] id: GO:0032343 name: aldosterone catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of aldosterone, a corticosteroid hormone that is produced by the zona glomerulosa of the adrenal cortex and regulates salt (sodium and potassium) and water balance." [PMID:16527843] is_a: GO:0006712 ! mineralocorticoid catabolic process is_a: GO:0008208 ! C21-steroid hormone catabolic process is_a: GO:0032341 ! aldosterone metabolic process is_a: GO:0034310 ! primary alcohol catabolic process is_a: GO:0042182 ! ketone catabolic process is_a: GO:0046185 ! aldehyde catabolic process is_a: GO:0120256 ! olefinic compound catabolic process intersection_of: GO:0009056 ! catabolic process intersection_of: RO:0004009 CHEBI:27584 ! has primary input relationship: RO:0004009 CHEBI:27584 ! has primary input property_value: RO:0002161 NCBITaxon:4895 [Term] id: GO:0032344 name: regulation of aldosterone metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving aldosterone." [GOC:mah] synonym: "regulation of aldosterone metabolism" EXACT [] is_a: GO:0010565 ! regulation of ketone metabolic process is_a: GO:0019218 ! regulation of steroid metabolic process is_a: GO:0032350 ! regulation of hormone metabolic process is_a: GO:0062012 ! regulation of small molecule metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0032341 ! regulates aldosterone metabolic process relationship: RO:0002211 GO:0032341 ! regulates aldosterone metabolic process property_value: RO:0002161 NCBITaxon:4895 [Term] id: GO:0032347 name: regulation of aldosterone biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of aldosterone." [GOC:mah] is_a: GO:0010566 ! regulation of ketone biosynthetic process is_a: GO:0032344 ! regulation of aldosterone metabolic process is_a: GO:0090030 ! regulation of steroid hormone biosynthetic process is_a: GO:1902930 ! regulation of alcohol biosynthetic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0032342 ! regulates aldosterone biosynthetic process relationship: RO:0002211 GO:0032342 ! regulates aldosterone biosynthetic process property_value: RO:0002161 NCBITaxon:4895 [Term] id: GO:0032348 name: negative regulation of aldosterone biosynthetic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of aldosterone." [GOC:mah] synonym: "down regulation of aldosterone biosynthetic process" EXACT [] synonym: "down-regulation of aldosterone biosynthetic process" EXACT [] synonym: "downregulation of aldosterone biosynthetic process" EXACT [] synonym: "inhibition of aldosterone biosynthetic process" NARROW [] is_a: GO:0032347 ! regulation of aldosterone biosynthetic process is_a: GO:0090032 ! negative regulation of steroid hormone biosynthetic process is_a: GO:1902931 ! negative regulation of alcohol biosynthetic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0032342 ! negatively regulates aldosterone biosynthetic process relationship: RO:0002212 GO:0032342 ! negatively regulates aldosterone biosynthetic process property_value: RO:0002161 NCBITaxon:4895 [Term] id: GO:0032349 name: positive regulation of aldosterone biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of aldosterone." [GOC:mah] synonym: "activation of aldosterone biosynthetic process" NARROW [] synonym: "stimulation of aldosterone biosynthetic process" NARROW [] synonym: "up regulation of aldosterone biosynthetic process" EXACT [] synonym: "up-regulation of aldosterone biosynthetic process" EXACT [] synonym: "upregulation of aldosterone biosynthetic process" EXACT [] is_a: GO:0032347 ! regulation of aldosterone biosynthetic process is_a: GO:0090031 ! positive regulation of steroid hormone biosynthetic process is_a: GO:1902932 ! positive regulation of alcohol biosynthetic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0032342 ! positively regulates aldosterone biosynthetic process relationship: RO:0002213 GO:0032342 ! positively regulates aldosterone biosynthetic process property_value: RO:0002161 NCBITaxon:4895 [Term] id: GO:0032350 name: regulation of hormone metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving any hormone." [GOC:mah] synonym: "regulation of hormone metabolism" EXACT [] is_a: GO:0010817 ! regulation of hormone levels is_a: GO:0019222 ! regulation of metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0042445 ! regulates hormone metabolic process relationship: RO:0002211 GO:0042445 ! regulates hormone metabolic process property_value: RO:0002161 NCBITaxon:4895 [Term] id: GO:0032351 name: negative regulation of hormone metabolic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving any hormone." [GOC:mah] synonym: "down regulation of hormone metabolic process" EXACT [] synonym: "down-regulation of hormone metabolic process" EXACT [] synonym: "downregulation of hormone metabolic process" EXACT [] synonym: "inhibition of hormone metabolic process" NARROW [] synonym: "negative regulation of hormone metabolism" EXACT [] is_a: GO:0009892 ! negative regulation of metabolic process is_a: GO:0032350 ! regulation of hormone metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0042445 ! negatively regulates hormone metabolic process relationship: RO:0002212 GO:0042445 ! negatively regulates hormone metabolic process property_value: RO:0002161 NCBITaxon:4895 [Term] id: GO:0032352 name: positive regulation of hormone metabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving any hormone." [GOC:mah] synonym: "activation of hormone metabolic process" NARROW [] synonym: "positive regulation of hormone metabolism" EXACT [] synonym: "stimulation of hormone metabolic process" NARROW [] synonym: "up regulation of hormone metabolic process" EXACT [] synonym: "up-regulation of hormone metabolic process" EXACT [] synonym: "upregulation of hormone metabolic process" EXACT [] is_a: GO:0009893 ! positive regulation of metabolic process is_a: GO:0032350 ! regulation of hormone metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0042445 ! positively regulates hormone metabolic process relationship: RO:0002213 GO:0042445 ! positively regulates hormone metabolic process property_value: RO:0002161 NCBITaxon:4895 [Term] id: GO:0032353 name: negative regulation of hormone biosynthetic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of hormones." [GOC:ai] synonym: "down regulation of hormone biosynthetic process" EXACT [] synonym: "down-regulation of hormone biosynthetic process" EXACT [] synonym: "downregulation of hormone biosynthetic process" EXACT [] synonym: "inhibition of hormone biosynthetic process" NARROW [] is_a: GO:0009890 ! negative regulation of biosynthetic process is_a: GO:0032351 ! negative regulation of hormone metabolic process is_a: GO:0046885 ! regulation of hormone biosynthetic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0042446 ! negatively regulates hormone biosynthetic process relationship: RO:0002212 GO:0042446 ! negatively regulates hormone biosynthetic process property_value: RO:0002161 NCBITaxon:4895 [Term] id: GO:0032355 name: response to estradiol namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of stimulus by estradiol, a C18 steroid hormone hydroxylated at C3 and C17 that acts as a potent estrogen." [GOC:mah, ISBN:0911910123] synonym: "response to E2 stimulus" EXACT [] synonym: "response to estradiol stimulus" EXACT [GOC:dos] is_a: GO:0033993 ! response to lipid is_a: GO:1901700 ! response to oxygen-containing compound intersection_of: GO:0050896 ! response to stimulus intersection_of: RO:0004009 CHEBI:23965 ! has primary input relationship: RO:0004009 CHEBI:23965 ! has primary input [Term] id: GO:0032364 name: intracellular oxygen homeostasis namespace: biological_process def: "A homeostatic process involved in the maintenance of a steady state level of oxygen within a cell." [GOC:rph] synonym: "cellular oxygen homeostasis" EXACT [] synonym: "oxygen homeostasis" BROAD [] is_a: GO:0055082 ! intracellular chemical homeostasis intersection_of: GO:0055082 ! intracellular chemical homeostasis intersection_of: RO:0002332 CHEBI:15379 ! regulates levels of relationship: RO:0002332 CHEBI:15379 ! regulates levels of property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/24224" xsd:anyURI [Term] id: GO:0032365 name: intracellular lipid transport namespace: biological_process def: "The directed movement of lipids within cells." [GOC:mah] is_a: GO:0006869 ! lipid transport is_a: GO:0046907 ! intracellular transport intersection_of: GO:0046907 ! intracellular transport intersection_of: RO:0004009 CHEBI:18059 ! has primary input [Term] id: GO:0032368 name: regulation of lipid transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah] is_a: GO:0051049 ! regulation of transport is_a: GO:1905952 ! regulation of lipid localization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0006869 ! regulates lipid transport relationship: RO:0002211 GO:0006869 ! regulates lipid transport [Term] id: GO:0032369 name: negative regulation of lipid transport namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah] synonym: "down regulation of lipid transport" EXACT [] synonym: "down-regulation of lipid transport" EXACT [] synonym: "downregulation of lipid transport" EXACT [] synonym: "inhibition of lipid transport" NARROW [] is_a: GO:0032368 ! regulation of lipid transport is_a: GO:0051051 ! negative regulation of transport is_a: GO:1905953 ! negative regulation of lipid localization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0006869 ! negatively regulates lipid transport relationship: RO:0002212 GO:0006869 ! negatively regulates lipid transport [Term] id: GO:0032370 name: positive regulation of lipid transport namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah] synonym: "activation of lipid transport" NARROW [] synonym: "stimulation of lipid transport" NARROW [] synonym: "up regulation of lipid transport" EXACT [] synonym: "up-regulation of lipid transport" EXACT [] synonym: "upregulation of lipid transport" EXACT [] is_a: GO:0032368 ! regulation of lipid transport is_a: GO:0051050 ! positive regulation of transport is_a: GO:1905954 ! positive regulation of lipid localization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0006869 ! positively regulates lipid transport relationship: RO:0002213 GO:0006869 ! positively regulates lipid transport [Term] id: GO:0032377 name: regulation of intracellular lipid transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the directed movement of lipids within cells." [GOC:mah] is_a: GO:0032368 ! regulation of lipid transport is_a: GO:0032386 ! regulation of intracellular transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0032365 ! regulates intracellular lipid transport relationship: RO:0002211 GO:0032365 ! regulates intracellular lipid transport [Term] id: GO:0032378 name: negative regulation of intracellular lipid transport namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of lipids within cells." [GOC:mah] synonym: "down regulation of intracellular lipid transport" EXACT [] synonym: "down-regulation of intracellular lipid transport" EXACT [] synonym: "downregulation of intracellular lipid transport" EXACT [] synonym: "inhibition of intracellular lipid transport" NARROW [] is_a: GO:0032369 ! negative regulation of lipid transport is_a: GO:0032377 ! regulation of intracellular lipid transport is_a: GO:0032387 ! negative regulation of intracellular transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0032365 ! negatively regulates intracellular lipid transport relationship: RO:0002212 GO:0032365 ! negatively regulates intracellular lipid transport [Term] id: GO:0032379 name: positive regulation of intracellular lipid transport namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the directed movement of lipids within cells." [GOC:mah] synonym: "activation of intracellular lipid transport" NARROW [] synonym: "stimulation of intracellular lipid transport" NARROW [] synonym: "up regulation of intracellular lipid transport" EXACT [] synonym: "up-regulation of intracellular lipid transport" EXACT [] synonym: "upregulation of intracellular lipid transport" EXACT [] is_a: GO:0032370 ! positive regulation of lipid transport is_a: GO:0032377 ! regulation of intracellular lipid transport is_a: GO:0032388 ! positive regulation of intracellular transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0032365 ! positively regulates intracellular lipid transport relationship: RO:0002213 GO:0032365 ! positively regulates intracellular lipid transport [Term] id: GO:0032386 name: regulation of intracellular transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the directed movement of substances within cells." [GOC:mah] subset: gocheck_do_not_annotate is_a: GO:0051049 ! regulation of transport is_a: GO:0060341 ! regulation of cellular localization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0046907 ! regulates intracellular transport relationship: RO:0002211 GO:0046907 ! regulates intracellular transport [Term] id: GO:0032387 name: negative regulation of intracellular transport namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of substances within cells." [GOC:mah] synonym: "down regulation of intracellular transport" EXACT [] synonym: "down-regulation of intracellular transport" EXACT [] synonym: "downregulation of intracellular transport" EXACT [] synonym: "inhibition of intracellular transport" NARROW [] is_a: GO:0032386 ! regulation of intracellular transport is_a: GO:0048523 ! negative regulation of cellular process is_a: GO:0051051 ! negative regulation of transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0046907 ! negatively regulates intracellular transport relationship: RO:0002212 GO:0046907 ! negatively regulates intracellular transport [Term] id: GO:0032388 name: positive regulation of intracellular transport namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the directed movement of substances within cells." [GOC:mah] synonym: "activation of intracellular transport" NARROW [] synonym: "stimulation of intracellular transport" NARROW [] synonym: "up regulation of intracellular transport" EXACT [] synonym: "up-regulation of intracellular transport" EXACT [] synonym: "upregulation of intracellular transport" EXACT [] is_a: GO:0032386 ! regulation of intracellular transport is_a: GO:0048522 ! positive regulation of cellular process is_a: GO:0051050 ! positive regulation of transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0046907 ! positively regulates intracellular transport relationship: RO:0002213 GO:0046907 ! positively regulates intracellular transport [Term] id: GO:0032394 name: MHC class Ib receptor activity namespace: molecular_function def: "Combining with an MHC class Ib protein complex and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. Class Ib here refers to non-classical class I molecules, such as those of the CD1 or HLA-E gene families." [GOC:add, GOC:signaling, ISBN:0781735149] comment: Note that this term is intended for annotation of gene products that act as receptors for MHC class Ib protein complexes, not for components of the MHC class Ib protein complexes themselves. synonym: "alpha-beta T cell receptor activity" RELATED [] synonym: "gamma-delta T cell receptor activity" RELATED [] synonym: "T cell receptor activity" RELATED [] is_a: BFO:0000003 is_a: GO:0004888 ! transmembrane signaling receptor activity is_a: GO:0140375 ! immune receptor activity relationship: BFO:0000051 GO:0023029 ! has part MHC class Ib protein binding [Term] id: GO:0032400 name: melanosome localization namespace: biological_process def: "Any process in which a melanosome is transported to, and/or maintained in, a specific location within the cell." [GOC:ln] synonym: "melanosome localisation" EXACT [GOC:mah] is_a: GO:0051875 ! pigment granule localization intersection_of: GO:0051179 ! localization intersection_of: RO:0004009 GO:0042470 ! has primary input melanosome relationship: RO:0004009 GO:0042470 ! has primary input melanosome [Term] id: GO:0032401 name: establishment of melanosome localization namespace: biological_process def: "The directed movement of a melanosome to a specific location." [GOC:mah] synonym: "establishment of melanosome localisation" EXACT [GOC:mah] is_a: GO:0051905 ! establishment of pigment granule localization relationship: BFO:0000050 GO:0032400 ! part of melanosome localization [Term] id: GO:0032402 name: melanosome transport namespace: biological_process def: "The directed movement of melanosomes into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ln] is_a: GO:0032400 ! melanosome localization is_a: GO:0032401 ! establishment of melanosome localization is_a: GO:0051904 ! pigment granule transport intersection_of: GO:0006810 ! transport intersection_of: RO:0004009 GO:0042470 ! has primary input melanosome [Term] id: GO:0032410 name: negative regulation of transporter activity namespace: biological_process def: "Any process that stops or reduces the activity of a transporter." [GOC:mah] subset: gocheck_obsoletion_candidate synonym: "down regulation of transporter activity" EXACT [] synonym: "down-regulation of transporter activity" EXACT [] synonym: "downregulation of transporter activity" EXACT [] synonym: "inhibition of transporter activity" NARROW [] is_a: GO:0044092 ! negative regulation of molecular function is_a: GO:0051051 ! negative regulation of transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0005215 ! negatively regulates transporter activity relationship: RO:0002212 GO:0005215 ! negatively regulates transporter activity [Term] id: GO:0032411 name: positive regulation of transporter activity namespace: biological_process def: "Any process that activates or increases the activity of a transporter." [GOC:mah] subset: gocheck_obsoletion_candidate synonym: "activation of transporter activity" NARROW [] synonym: "stimulation of transporter activity" NARROW [] synonym: "up regulation of transporter activity" EXACT [] synonym: "up-regulation of transporter activity" EXACT [] synonym: "upregulation of transporter activity" EXACT [] is_a: GO:0044093 ! positive regulation of molecular function is_a: GO:0051050 ! positive regulation of transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0005215 ! positively regulates transporter activity relationship: RO:0002213 GO:0005215 ! positively regulates transporter activity [Term] id: GO:0032413 name: negative regulation of ion transmembrane transporter activity namespace: biological_process def: "Any process that stops or reduces the activity of an ion transporter." [GOC:mah, GOC:tb] subset: gocheck_obsoletion_candidate synonym: "down regulation of ion transporter activity" EXACT [] synonym: "down-regulation of ion transporter activity" EXACT [] synonym: "downregulation of ion transporter activity" EXACT [] synonym: "inhibition of ion transporter activity" NARROW [] synonym: "negative regulation of ion transporter activity" EXACT [GOC:tb] is_a: GO:0022898 ! regulation of transmembrane transporter activity is_a: GO:0032410 ! negative regulation of transporter activity is_a: GO:0034766 ! negative regulation of monoatomic ion transmembrane transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0015075 ! negatively regulates monoatomic ion transmembrane transporter activity relationship: RO:0002212 GO:0015075 ! negatively regulates monoatomic ion transmembrane transporter activity [Term] id: GO:0032414 name: positive regulation of ion transmembrane transporter activity namespace: biological_process def: "Any process that activates or increases the activity of an ion transporter." [GOC:mah, GOC:tb] subset: gocheck_obsoletion_candidate synonym: "activation of ion transporter activity" NARROW [] synonym: "positive regulation of ion transporter activity" EXACT [GOC:tb] synonym: "stimulation of ion transporter activity" NARROW [] synonym: "up regulation of ion transporter activity" EXACT [] synonym: "up-regulation of ion transporter activity" EXACT [] synonym: "upregulation of ion transporter activity" EXACT [] is_a: GO:0022898 ! regulation of transmembrane transporter activity is_a: GO:0032411 ! positive regulation of transporter activity is_a: GO:0034767 ! positive regulation of monoatomic ion transmembrane transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0015075 ! positively regulates monoatomic ion transmembrane transporter activity relationship: RO:0002213 GO:0015075 ! positively regulates monoatomic ion transmembrane transporter activity [Term] id: GO:0032418 name: lysosome localization namespace: biological_process def: "Any process in which a lysosome is transported to, and/or maintained in, a specific location." [GOC:mah] synonym: "lysosome localisation" EXACT [GOC:mah] is_a: GO:1990849 ! vacuolar localization intersection_of: GO:0051179 ! localization intersection_of: RO:0004009 GO:0005764 ! has primary input lysosome relationship: RO:0004009 GO:0005764 ! has primary input lysosome [Term] id: GO:0032432 name: actin filament bundle namespace: cellular_component def: "An assembly of actin filaments that are on the same axis but may be oriented with the same or opposite polarities and may be packed with different levels of tightness." [GOC:mah] synonym: "actin cable" RELATED [GOC:mah] is_a: GO:0110165 ! cellular anatomical structure relationship: BFO:0000050 GO:0015629 ! part of actin cytoskeleton relationship: BFO:0000051 GO:0005884 ! has part actin filament [Term] id: GO:0032438 name: melanosome organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a melanosome. A melanosome is a tissue-specific, membrane-bounded cytoplasmic organelle within which melanin pigments are synthesized and stored." [GOC:vk] synonym: "melanosome organisation" EXACT [GOC:mah] synonym: "melanosome organization and biogenesis" RELATED [GOC:mah] is_a: GO:0048753 ! pigment granule organization intersection_of: GO:0016043 ! cellular component organization intersection_of: RO:0002592 GO:0042470 ! results in organization of melanosome relationship: RO:0002592 GO:0042470 ! results in organization of melanosome [Term] id: GO:0032468 name: Golgi calcium ion homeostasis namespace: biological_process def: "Any process involved in the maintenance of an internal steady state of calcium ions within the Golgi apparatus of a cell or between the Golgi and its surroundings." [GOC:mah] synonym: "calcium ion homeostasis in Golgi" EXACT [] synonym: "Golgi calcium ion concentration regulation" EXACT [] synonym: "regulation of calcium ion concentration in Golgi" EXACT [] synonym: "regulation of Golgi calcium ion concentration" EXACT [] is_a: GO:0006874 ! intracellular calcium ion homeostasis intersection_of: GO:0055074 ! calcium ion homeostasis intersection_of: BFO:0000066 GO:0005794 ! occurs in Golgi apparatus relationship: BFO:0000066 GO:0005794 ! occurs in Golgi apparatus relationship: RO:0002162 NCBITaxon:2759 ! in taxon Eukaryota [Term] id: GO:0032472 name: Golgi calcium ion transport namespace: biological_process def: "The directed movement of calcium ions (Ca2+) into, out of or within the Golgi apparatus." [GOC:mah] synonym: "Golgi calcium transport" EXACT [] is_a: GO:0006816 ! calcium ion transport intersection_of: GO:0006810 ! transport intersection_of: RO:0002344 GO:0005794 ! results in transport to from or in Golgi apparatus intersection_of: RO:0004009 CHEBI:29108 ! has primary input relationship: RO:0002344 GO:0005794 ! results in transport to from or in Golgi apparatus [Term] id: GO:0032479 name: regulation of type I interferon production namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of interferon type I production. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families." [GOC:add, GOC:mah] synonym: "regulation of type I IFN production" EXACT [] xref: Reactome:R-HSA-3134975 "Regulation of innate immune responses to cytosolic DNA" is_a: GO:0001817 ! regulation of cytokine production intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0032606 ! regulates type I interferon production relationship: RO:0002211 GO:0032606 ! regulates type I interferon production property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0032480 name: negative regulation of type I interferon production namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of type I interferon production. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families." [GOC:add, GOC:mah] synonym: "down regulation of type I interferon production" EXACT [] synonym: "down-regulation of type I interferon production" EXACT [] synonym: "downregulation of type I interferon production" EXACT [] synonym: "inhibition of type I interferon production" NARROW [] synonym: "negative regulation of type I IFN production" EXACT [] xref: Reactome:R-HSA-936440 "Negative regulators of DDX58/IFIH1 signaling" is_a: GO:0001818 ! negative regulation of cytokine production is_a: GO:0032479 ! regulation of type I interferon production intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0032606 ! negatively regulates type I interferon production relationship: RO:0002212 GO:0032606 ! negatively regulates type I interferon production property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0032481 name: positive regulation of type I interferon production namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of type I interferon production. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families." [GOC:add, GOC:mah] synonym: "activation of type I interferon production" NARROW [] synonym: "positive regulation of type I IFN production" EXACT [] synonym: "stimulation of type I interferon production" NARROW [] synonym: "up regulation of type I interferon production" EXACT [] synonym: "up-regulation of type I interferon production" EXACT [] synonym: "upregulation of type I interferon production" EXACT [] xref: Reactome:R-HSA-1834949 "Cytosolic sensors of pathogen-associated DNA" is_a: GO:0001819 ! positive regulation of cytokine production is_a: GO:0032479 ! regulation of type I interferon production intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0032606 ! positively regulates type I interferon production relationship: RO:0002213 GO:0032606 ! positively regulates type I interferon production property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0032501 name: multicellular organismal process namespace: biological_process def: "Any biological process, occurring at the level of a multicellular organism, pertinent to its function." [GOC:curators, GOC:dph, GOC:isa_complete, GOC:tb] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_annotate subset: goslim_pir synonym: "organismal physiological process" EXACT [] synonym: "single-multicellular organism process" RELATED [] is_a: GO:0008150 ! biological_process disjoint_from: GO:0044848 ! biological phase property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/27189" xsd:anyURI property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 creation_date: 2012-09-19T16:07:47Z [Term] id: GO:0032502 name: developmental process namespace: biological_process def: "A biological process whose specific outcome is the progression of an integrated living unit: an anatomical structure (which may be a subcellular structure, cell, tissue, or organ), or organism over time from an initial condition to a later condition." [GOC:isa_complete] subset: goslim_agr subset: goslim_flybase_ribbon subset: goslim_pir synonym: "development" NARROW [] synonym: "single-organism developmental process" RELATED [] is_a: GO:0008150 ! biological_process disjoint_from: GO:0044848 ! biological phase creation_date: 2012-12-19T12:21:31Z [Term] id: GO:0032507 name: maintenance of protein location in cell namespace: biological_process def: "Any process in which a protein is maintained in a specific location within, or in the membrane of, a cell, and is prevented from moving elsewhere." [GOC:isa_complete, GOC:mah] synonym: "maintenance of protein localization in cell" RELATED [GOC:dph, GOC:tb] is_a: GO:0045185 ! maintenance of protein location is_a: GO:0051651 ! maintenance of location in cell intersection_of: GO:0045185 ! maintenance of protein location intersection_of: BFO:0000066 CL:0000000 ! occurs in cell relationship: RO:0002162 NCBITaxon:131567 ! in taxon cellular organisms [Term] id: GO:0032528 name: microvillus organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a microvillus, a thin cylindrical membrane-covered projection on the surface of a cell." [GOC:mah] synonym: "microvillus organisation" EXACT [GOC:mah] synonym: "microvillus organization and biogenesis" RELATED [GOC:mah] is_a: GO:0120036 ! plasma membrane bounded cell projection organization intersection_of: GO:0016043 ! cellular component organization intersection_of: RO:0002592 GO:0005902 ! results in organization of microvillus relationship: RO:0002592 GO:0005902 ! results in organization of microvillus property_value: RO:0002161 NCBITaxon:4751 [Term] id: GO:0032529 name: follicle cell microvillus organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a microvillus on a follicle cell. A microvillus is a thin cylindrical membrane-covered projection on the surface of an animal cell containing a core bundle of actin filaments." [GOC:sart, PMID:16507588] synonym: "follicle cell microvillus organisation" EXACT [GOC:mah] synonym: "follicle cell microvillus organization and biogenesis" RELATED [GOC:mah] is_a: GO:0032528 ! microvillus organization intersection_of: GO:0032528 ! microvillus organization intersection_of: BFO:0000066 CL:0000477 ! occurs in follicle cell of egg chamber relationship: BFO:0000066 CL:0000477 ! occurs in follicle cell of egg chamber property_value: RO:0002161 NCBITaxon:4751 [Term] id: GO:0032530 name: regulation of microvillus organization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a microvillus." [GOC:mah] synonym: "regulation of microvillus organisation" EXACT [GOC:mah] synonym: "regulation of microvillus organization and biogenesis" RELATED [GOC:mah] is_a: GO:0120035 ! regulation of plasma membrane bounded cell projection organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0032528 ! regulates microvillus organization relationship: RO:0002211 GO:0032528 ! regulates microvillus organization property_value: RO:0002161 NCBITaxon:4751 [Term] id: GO:0032531 name: regulation of follicle cell microvillus organization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a microvillus on a follicle cell." [GOC:mah] synonym: "regulation of follicle cell microvillus organisation" EXACT [GOC:mah] synonym: "regulation of follicle cell microvillus organization and biogenesis" RELATED [GOC:mah] is_a: GO:0032530 ! regulation of microvillus organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0032529 ! regulates follicle cell microvillus organization relationship: RO:0002211 GO:0032529 ! regulates follicle cell microvillus organization property_value: RO:0002161 NCBITaxon:4751 [Term] id: GO:0032534 name: regulation of microvillus assembly namespace: biological_process def: "A process that modulates the formation of a microvillus." [GOC:mah] synonym: "regulation of microvillus biogenesis" RELATED [GOC:mah] is_a: GO:0032530 ! regulation of microvillus organization is_a: GO:0120032 ! regulation of plasma membrane bounded cell projection assembly intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0030033 ! regulates microvillus assembly relationship: RO:0002211 GO:0030033 ! regulates microvillus assembly [Term] id: GO:0032535 name: regulation of cellular component size namespace: biological_process def: "A process that modulates the size of a cellular component." [GOC:mah] is_a: GO:0016043 ! cellular component organization is_a: GO:0090066 ! regulation of anatomical structure size [Term] id: GO:0032543 name: mitochondrial translation namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a protein in a mitochondrion. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein; the mitochondrion has its own ribosomes and transfer RNAs, and uses a genetic code that differs from the nuclear code." [GOC:go_curators] subset: goslim_yeast synonym: "mitochondrial protein anabolism" EXACT [] synonym: "mitochondrial protein biosynthesis" EXACT [] synonym: "mitochondrial protein formation" EXACT [] synonym: "mitochondrial protein synthesis" EXACT [] synonym: "mitochondrial protein translation" EXACT [] xref: Reactome:R-HSA-5368287 "Mitochondrial translation" is_a: GO:0006412 ! translation intersection_of: GO:0006412 ! translation intersection_of: BFO:0000050 GO:0140053 ! part of mitochondrial gene expression intersection_of: BFO:0000066 GO:0005739 ! occurs in mitochondrion relationship: BFO:0000050 GO:0140053 ! part of mitochondrial gene expression [Term] id: GO:0032544 name: plastid translation namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a protein in a plastid. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein; the plastid has its own ribosomes and transfer RNAs, and uses a genetic code that differs from the nuclear code." [GOC:go_curators] synonym: "plastid protein anabolism" EXACT [] synonym: "plastid protein biosynthesis" EXACT [] synonym: "plastid protein formation" EXACT [] synonym: "plastid protein synthesis" EXACT [] synonym: "plastid protein translation" EXACT [] is_a: GO:0006412 ! translation is_a: GO:0009657 ! plastid organization intersection_of: GO:0006412 ! translation intersection_of: BFO:0000066 GO:0009536 ! occurs in plastid relationship: BFO:0000066 GO:0009536 ! occurs in plastid property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:28009 property_value: RO:0002161 NCBITaxon:33208 property_value: RO:0002161 NCBITaxon:4751 property_value: RO:0002161 NCBITaxon:554915 [Term] id: GO:0032553 name: ribonucleotide binding namespace: molecular_function def: "Binding to a ribonucleotide, any compound consisting of a ribonucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose moiety." [GOC:mah] is_a: GO:0000166 ! nucleotide binding is_a: GO:0097367 ! carbohydrate derivative binding intersection_of: GO:0005488 ! binding intersection_of: RO:0004009 CHEBI:26561 ! has primary input relationship: RO:0004009 CHEBI:26561 ! has primary input [Term] id: GO:0032555 name: purine ribonucleotide binding namespace: molecular_function def: "Binding to a purine ribonucleotide, any compound consisting of a purine ribonucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose moiety." [GOC:mah] is_a: GO:0017076 ! purine nucleotide binding is_a: GO:0032553 ! ribonucleotide binding intersection_of: GO:0005488 ! binding intersection_of: RO:0004009 CHEBI:26400 ! has primary input relationship: RO:0004009 CHEBI:26400 ! has primary input [Term] id: GO:0032559 name: adenyl ribonucleotide binding namespace: molecular_function def: "Binding to an adenyl ribonucleotide, any compound consisting of adenosine esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose moiety." [GOC:mah] is_a: GO:0030554 ! adenyl nucleotide binding is_a: GO:0032555 ! purine ribonucleotide binding intersection_of: GO:0005488 ! binding intersection_of: RO:0004009 CHEBI:61296 ! has primary input relationship: RO:0004009 CHEBI:61296 ! has primary input [Term] id: GO:0032570 name: response to progesterone namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a progesterone stimulus." [GOC:sl] synonym: "response to progesterone stimulus" EXACT [GOC:dos] is_a: GO:0048545 ! response to steroid hormone is_a: GO:1901654 ! response to ketone intersection_of: GO:0050896 ! response to stimulus intersection_of: RO:0004009 CHEBI:17026 ! has primary input relationship: RO:0004009 CHEBI:17026 ! has primary input property_value: RO:0002161 NCBITaxon:4751 [Term] id: GO:0032589 name: neuron projection membrane namespace: cellular_component def: "The portion of the plasma membrane surrounding a neuron projection." [GOC:mah] is_a: GO:0031253 ! cell projection membrane is_a: GO:0031256 ! leading edge membrane intersection_of: GO:0016020 ! membrane intersection_of: RO:0002007 GO:0043005 ! bounding layer of neuron projection relationship: RO:0002007 GO:0043005 ! bounding layer of neuron projection [Term] id: GO:0032590 name: dendrite membrane namespace: cellular_component def: "The portion of the plasma membrane surrounding a dendrite." [GOC:mah] is_a: GO:0032589 ! neuron projection membrane intersection_of: GO:0016020 ! membrane intersection_of: RO:0002007 GO:0030425 ! bounding layer of dendrite relationship: RO:0002007 GO:0030425 ! bounding layer of dendrite [Term] id: GO:0032594 name: protein transport within lipid bilayer namespace: biological_process def: "The directed movement of a protein from one location to another within a lipid bilayer." [GOC:mah] synonym: "protein translocation within membrane" EXACT [] synonym: "receptor translocation within membrane" NARROW [] synonym: "receptor transport within lipid bilayer" NARROW [] is_a: GO:0006886 ! intracellular protein transport is_a: GO:0061024 ! membrane organization intersection_of: GO:0015031 ! protein transport intersection_of: BFO:0000066 GO:0016020 ! occurs in membrane relationship: BFO:0000066 GO:0016020 ! occurs in membrane [Term] id: GO:0032606 name: type I interferon production namespace: biological_process def: "The appearance of type I interferon due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families." [GOC:add, ISBN:0126896631, PMID:15546383, PMID:16681834] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms. subset: gocheck_do_not_annotate synonym: "interferon type I production" EXACT [] synonym: "type I IFN production" EXACT [GOC:mah] synonym: "type I interferon biosynthetic process" NARROW [] synonym: "type I interferon secretion" NARROW [] is_a: GO:0001816 ! cytokine production property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0032609 name: type II interferon production namespace: biological_process def: "The appearance of interferon-gamma due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. Interferon-gamma is also known as type II interferon." [GOC:add, GOC:mah, PMID:15546383] subset: gocheck_do_not_annotate synonym: "IFNG production" EXACT [GOC:mah] synonym: "interferon-gamma biosynthetic process" NARROW [] synonym: "interferon-gamma production" EXACT [] synonym: "interferon-gamma secretion" NARROW [] synonym: "type II IFN production" EXACT [GOC:mah] is_a: GO:0001816 ! cytokine production property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0032611 name: interleukin-1 beta production namespace: biological_process def: "The appearance of interleukin-1 beta due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah] subset: gocheck_do_not_annotate synonym: "IL-1 beta production" EXACT [] synonym: "interleukin-1 beta biosynthetic process" NARROW [] synonym: "interleukin-1 beta secretion" NARROW [] is_a: GO:0032612 ! interleukin-1 production property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0032612 name: interleukin-1 production namespace: biological_process def: "The appearance of interleukin-1 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah] subset: gocheck_do_not_annotate synonym: "IL-1 production" EXACT [] synonym: "interleukin-1 biosynthetic process" NARROW [] synonym: "interleukin-1 secretion" NARROW [] is_a: GO:0001816 ! cytokine production property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0032613 name: interleukin-10 production namespace: biological_process def: "The appearance of interleukin-10 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah] subset: gocheck_do_not_annotate synonym: "IL-10 production" EXACT [] synonym: "interleukin-10 biosynthetic process" NARROW [] synonym: "interleukin-10 secretion" NARROW [] is_a: GO:0001816 ! cytokine production property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0032616 name: interleukin-13 production namespace: biological_process def: "The appearance of interleukin-13 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah] subset: gocheck_do_not_annotate synonym: "IL-13 production" EXACT [] synonym: "interleukin-13 biosynthetic process" NARROW [] synonym: "interleukin-13 secretion" NARROW [] is_a: GO:0001816 ! cytokine production property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0032620 name: interleukin-17 production namespace: biological_process def: "The appearance of any member of the interleukin-17 family of cytokines due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah, GOC:rv, Wikipedia:Interleukin_17] subset: gocheck_do_not_annotate synonym: "CTLA-8 production" EXACT [GOC:BHF] synonym: "Cytotoxic T-lymphocyte-associated antigen 8 production" EXACT [GOC:BHF] synonym: "IL-17 production" EXACT [] synonym: "interleukin-17 biosynthetic process" NARROW [] synonym: "interleukin-17 secretion" NARROW [] is_a: GO:0001816 ! cytokine production property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0032623 name: interleukin-2 production namespace: biological_process def: "The appearance of interleukin-2 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah] subset: gocheck_do_not_annotate synonym: "IL-2 production" EXACT [] synonym: "interleukin-2 biosynthetic process" NARROW [] synonym: "interleukin-2 secretion" NARROW [] is_a: GO:0001816 ! cytokine production property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0032626 name: interleukin-22 production namespace: biological_process def: "The appearance of interleukin-22 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah] subset: gocheck_do_not_annotate synonym: "IL-22 production" EXACT [] synonym: "IL22 production" EXACT [GOC:BHF] synonym: "ILTIF production" EXACT [GOC:BHF] synonym: "interleukin-22 biosynthetic process" NARROW [] synonym: "interleukin-22 secretion" NARROW [] synonym: "ZCYTO18 production" NARROW [GOC:BHF] is_a: GO:0001816 ! cytokine production property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0032633 name: interleukin-4 production namespace: biological_process def: "The appearance of interleukin-4 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah] subset: gocheck_do_not_annotate synonym: "IL-4 production" EXACT [] synonym: "interleukin-4 biosynthetic process" NARROW [] synonym: "interleukin-4 secretion" NARROW [] is_a: GO:0001816 ! cytokine production property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0032634 name: interleukin-5 production namespace: biological_process def: "The appearance of interleukin-5 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah] subset: gocheck_do_not_annotate synonym: "IL-5 production" EXACT [] synonym: "interleukin-5 biosynthetic process" NARROW [] synonym: "interleukin-5 secretion" NARROW [] is_a: GO:0001816 ! cytokine production property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0032635 name: interleukin-6 production namespace: biological_process def: "The appearance of interleukin-6 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah] subset: gocheck_do_not_annotate synonym: "IL-6 production" EXACT [] synonym: "interleukin-6 biosynthetic process" NARROW [] synonym: "interleukin-6 secretion" NARROW [] is_a: GO:0001816 ! cytokine production property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0032637 name: interleukin-8 production namespace: biological_process def: "The appearance of interleukin-8 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah] subset: gocheck_do_not_annotate synonym: "IL-8 production" EXACT [] synonym: "interleukin-8 biosynthetic process" NARROW [] synonym: "interleukin-8 secretion" NARROW [] is_a: GO:0001816 ! cytokine production property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0032638 name: interleukin-9 production namespace: biological_process def: "The appearance of interleukin-9 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah] subset: gocheck_do_not_annotate synonym: "IL-9 production" EXACT [] synonym: "interleukin-9 biosynthetic process" NARROW [] synonym: "interleukin-9 secretion" NARROW [] is_a: GO:0001816 ! cytokine production property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0032640 name: tumor necrosis factor production namespace: biological_process def: "The appearance of tumor necrosis factor due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. Tumor necrosis factor is an inflammatory cytokine produced by macrophages/monocytes during acute inflammation and which is responsible for a diverse range of signaling events within cells, leading to necrosis or apoptosis." [GOC:mah, PMID:10891884, PMID:15560120] comment: Note that this term refers only to the specific, original 'tumor necrosis factor' protein (TNF) and not other members of the tumor necrosis factor superfamily (those with the gene symbol root 'TNFSF'). That this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms. subset: gocheck_do_not_annotate synonym: "cachectin production" EXACT [] synonym: "TNF alpha biosynthesis" NARROW [] synonym: "TNF biosynthesis" NARROW [] synonym: "TNF biosynthetic process" NARROW [] synonym: "TNF production" EXACT [] synonym: "TNF-alpha biosynthesis" NARROW [] synonym: "TNF-alpha biosynthetic process" NARROW [] synonym: "TNF-alpha production" RELATED [] synonym: "Tnfa production" RELATED [] synonym: "tumor necrosis factor anabolism" NARROW [] synonym: "tumor necrosis factor biosynthesis" NARROW [] synonym: "tumor necrosis factor biosynthetic process" NARROW [] synonym: "tumor necrosis factor formation" NARROW [] synonym: "tumor necrosis factor secretion" NARROW [] synonym: "tumor necrosis factor synthesis" NARROW [] synonym: "tumor necrosis factor-alpha production" RELATED [] is_a: GO:0071706 ! tumor necrosis factor superfamily cytokine production property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 creation_date: 2015-06-15T22:59:26Z [Term] id: GO:0032649 name: regulation of type II interferon production namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of interferon-gamma production. Interferon-gamma is also known as type II interferon." [GOC:add, GOC:mah, PMID:15546383] synonym: "regulation of interferon-gamma biosynthetic process" NARROW [] synonym: "regulation of interferon-gamma production" EXACT [] synonym: "regulation of interferon-gamma secretion" NARROW [] is_a: GO:0001817 ! regulation of cytokine production intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0032609 ! regulates type II interferon production relationship: RO:0002211 GO:0032609 ! regulates type II interferon production property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0032651 name: regulation of interleukin-1 beta production namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of interleukin-1 beta production." [GOC:mah] synonym: "regulation of IL-1 beta production" EXACT [] synonym: "regulation of interleukin-1 beta biosynthetic process" NARROW [] synonym: "regulation of interleukin-1 beta secretion" NARROW [] is_a: GO:0032652 ! regulation of interleukin-1 production intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0032611 ! regulates interleukin-1 beta production relationship: RO:0002211 GO:0032611 ! regulates interleukin-1 beta production property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0032652 name: regulation of interleukin-1 production namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of interleukin-1 production." [GOC:mah] synonym: "regulation of IL-1 production" EXACT [] synonym: "regulation of interleukin-1 biosynthetic process" NARROW [] synonym: "regulation of interleukin-1 secretion" NARROW [] is_a: GO:0001817 ! regulation of cytokine production intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0032612 ! regulates interleukin-1 production relationship: RO:0002211 GO:0032612 ! regulates interleukin-1 production property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0032653 name: regulation of interleukin-10 production namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of interleukin-10 production." [GOC:mah] synonym: "regulation of IL-10 production" EXACT [] synonym: "regulation of interleukin-10 biosynthetic process" NARROW [] synonym: "regulation of interleukin-10 secretion" NARROW [] is_a: GO:0001817 ! regulation of cytokine production intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0032613 ! regulates interleukin-10 production relationship: RO:0002211 GO:0032613 ! regulates interleukin-10 production property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0032656 name: regulation of interleukin-13 production namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of interleukin-13 production." [GOC:mah] synonym: "regulation of IL-13 production" EXACT [] synonym: "regulation of interleukin-13 biosynthetic process" NARROW [] synonym: "regulation of interleukin-13 secretion" NARROW [] is_a: GO:0001817 ! regulation of cytokine production intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0032616 ! regulates interleukin-13 production relationship: RO:0002211 GO:0032616 ! regulates interleukin-13 production property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0032660 name: regulation of interleukin-17 production namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of production of any member of the interleukin-17 family of cytokines." [GOC:add, GOC:mah, PMID:16482511] synonym: "regulation of CTLA-8 production" EXACT [GOC:TermGenie] synonym: "regulation of Cytotoxic T-lymphocyte-associated antigen 8 secretion" EXACT [] synonym: "regulation of IL-17 production" EXACT [] synonym: "regulation of interleukin-17 biosynthetic process" NARROW [] synonym: "regulation of interleukin-17 secretion" NARROW [] is_a: GO:0001817 ! regulation of cytokine production intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0032620 ! regulates interleukin-17 production relationship: RO:0002211 GO:0032620 ! regulates interleukin-17 production property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0032663 name: regulation of interleukin-2 production namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of interleukin-2 production." [GOC:mah] synonym: "regulation of IL-2 production" EXACT [] synonym: "regulation of interleukin-2 biosynthetic process" NARROW [] synonym: "regulation of interleukin-2 secretion" NARROW [] is_a: GO:0001817 ! regulation of cytokine production intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0032623 ! regulates interleukin-2 production relationship: RO:0002211 GO:0032623 ! regulates interleukin-2 production property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0032666 name: regulation of interleukin-22 production namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of interleukin-22 production." [GOC:mah] synonym: "regulation of IL-22 production" EXACT [] synonym: "regulation of interleukin-22 biosynthetic process" NARROW [] is_a: GO:0001817 ! regulation of cytokine production intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0032626 ! regulates interleukin-22 production relationship: RO:0002211 GO:0032626 ! regulates interleukin-22 production property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0032673 name: regulation of interleukin-4 production namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of interleukin-4 production." [GOC:mah, PMID:29778524] synonym: "regulation of IL-4 production" EXACT [] synonym: "regulation of interleukin-4 biosynthetic process" NARROW [] synonym: "regulation of interleukin-4 secretion" NARROW [] is_a: GO:0001817 ! regulation of cytokine production intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0032633 ! regulates interleukin-4 production relationship: RO:0002211 GO:0032633 ! regulates interleukin-4 production property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0032674 name: regulation of interleukin-5 production namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of interleukin-5 production." [GOC:mah] synonym: "regulation of IL-5 production" EXACT [] synonym: "regulation of interleukin-5 biosynthetic process" NARROW [] synonym: "regulation of interleukin-5 secretion" NARROW [] is_a: GO:0001817 ! regulation of cytokine production intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0032634 ! regulates interleukin-5 production relationship: RO:0002211 GO:0032634 ! regulates interleukin-5 production property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0032675 name: regulation of interleukin-6 production namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of interleukin-6 production." [GOC:mah] synonym: "regulation of IL-6 production" EXACT [] synonym: "regulation of interleukin-6 biosynthetic process" NARROW [] is_a: GO:0001817 ! regulation of cytokine production intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0032635 ! regulates interleukin-6 production relationship: RO:0002211 GO:0032635 ! regulates interleukin-6 production property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0032677 name: regulation of interleukin-8 production namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of interleukin-8 production." [GOC:mah] synonym: "regulation of IL-8 production" EXACT [] synonym: "regulation of interleukin-8 biosynthetic process" NARROW [] synonym: "regulation of interleukin-8 secretion" NARROW [] is_a: GO:0001817 ! regulation of cytokine production intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0032637 ! regulates interleukin-8 production relationship: RO:0002211 GO:0032637 ! regulates interleukin-8 production property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0032678 name: regulation of interleukin-9 production namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of interleukin-9 production." [GOC:mah] synonym: "regulation of IL-9 production" EXACT [] synonym: "regulation of interleukin-9 biosynthetic process" NARROW [] is_a: GO:0001817 ! regulation of cytokine production intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0032638 ! regulates interleukin-9 production relationship: RO:0002211 GO:0032638 ! regulates interleukin-9 production property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0032680 name: regulation of tumor necrosis factor production namespace: biological_process def: "Any process that modulates the frequency, rate or extent of tumor necrosis factor production." [GOC:mah, PMID:10891884, PMID:15560120] comment: Note that this term refers only to the specific, original 'tumor necrosis factor' protein (TNF) and not other members of the tumor necrosis factor superfamily (those with the gene symbol root 'TNFSF'). synonym: "regulation of cachectin production" EXACT [GOC:TermGenie] synonym: "regulation of TNF production" EXACT [] synonym: "regulation of TNF-alpha production" EXACT [] synonym: "regulation of tumor necrosis factor biosynthetic process" NARROW [] synonym: "regulation of tumor necrosis factor secretion" NARROW [] synonym: "regulation of tumor necrosis factor-alpha production" EXACT [] is_a: GO:1903555 ! regulation of tumor necrosis factor superfamily cytokine production intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0032640 ! regulates tumor necrosis factor production relationship: RO:0002211 GO:0032640 ! regulates tumor necrosis factor production property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 creation_date: 2015-07-09T19:50:02Z [Term] id: GO:0032689 name: negative regulation of type II interferon production namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interferon-gamma production. Interferon-gamma is also known as type II interferon." [GOC:add, GOC:mah, PMID:15546383] synonym: "down regulation of interferon-gamma production" EXACT [] synonym: "down-regulation of interferon-gamma production" EXACT [] synonym: "downregulation of interferon-gamma production" EXACT [] synonym: "inhibition of interferon-gamma production" NARROW [] synonym: "negative regulation of interferon-gamma biosynthetic process" NARROW [] synonym: "negative regulation of interferon-gamma production" EXACT [] synonym: "negative regulation of interferon-gamma secretion" NARROW [] is_a: GO:0001818 ! negative regulation of cytokine production is_a: GO:0032649 ! regulation of type II interferon production intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0032609 ! negatively regulates type II interferon production relationship: RO:0002212 GO:0032609 ! negatively regulates type II interferon production property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0032691 name: negative regulation of interleukin-1 beta production namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-1 beta production." [GOC:mah] synonym: "down regulation of interleukin-1 beta production" EXACT [] synonym: "down-regulation of interleukin-1 beta production" EXACT [] synonym: "downregulation of interleukin-1 beta production" EXACT [] synonym: "inhibition of interleukin-1 beta production" NARROW [] synonym: "negative regulation of IL-1 beta production" EXACT [] synonym: "negative regulation of interleukin-1 beta biosynthetic process" NARROW [] synonym: "negative regulation of interleukin-1 beta secretion" NARROW [] is_a: GO:0032651 ! regulation of interleukin-1 beta production is_a: GO:0032692 ! negative regulation of interleukin-1 production intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0032611 ! negatively regulates interleukin-1 beta production relationship: RO:0002212 GO:0032611 ! negatively regulates interleukin-1 beta production property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0032692 name: negative regulation of interleukin-1 production namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-1 production." [GOC:mah] synonym: "down regulation of interleukin-1 production" EXACT [] synonym: "down-regulation of interleukin-1 production" EXACT [] synonym: "downregulation of interleukin-1 production" EXACT [] synonym: "inhibition of interleukin-1 production" NARROW [] synonym: "negative regulation of IL-1 production" EXACT [] synonym: "negative regulation of interleukin-1 biosynthetic process" NARROW [] synonym: "negative regulation of interleukin-1 secretion" NARROW [] is_a: GO:0001818 ! negative regulation of cytokine production is_a: GO:0032652 ! regulation of interleukin-1 production intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0032612 ! negatively regulates interleukin-1 production relationship: RO:0002212 GO:0032612 ! negatively regulates interleukin-1 production property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0032693 name: negative regulation of interleukin-10 production namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-10 production." [GOC:mah] synonym: "down regulation of interleukin-10 production" EXACT [] synonym: "down-regulation of interleukin-10 production" EXACT [] synonym: "downregulation of interleukin-10 production" EXACT [] synonym: "inhibition of interleukin-10 production" NARROW [] synonym: "negative regulation of IL-10 production" EXACT [] synonym: "negative regulation of interleukin-10 biosynthetic process" NARROW [] synonym: "negative regulation of interleukin-10 secretion" NARROW [] is_a: GO:0001818 ! negative regulation of cytokine production is_a: GO:0032653 ! regulation of interleukin-10 production intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0032613 ! negatively regulates interleukin-10 production relationship: RO:0002212 GO:0032613 ! negatively regulates interleukin-10 production property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0032696 name: negative regulation of interleukin-13 production namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-13 production." [GOC:mah] synonym: "down regulation of interleukin-13 production" EXACT [] synonym: "down-regulation of interleukin-13 production" EXACT [] synonym: "downregulation of interleukin-13 production" EXACT [] synonym: "inhibition of interleukin-13 production" NARROW [] synonym: "negative regulation of IL-13 production" EXACT [] synonym: "negative regulation of interleukin-13 biosynthetic process" NARROW [] synonym: "negative regulation of interleukin-13 secretion" NARROW [] is_a: GO:0001818 ! negative regulation of cytokine production is_a: GO:0032656 ! regulation of interleukin-13 production intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0032616 ! negatively regulates interleukin-13 production relationship: RO:0002212 GO:0032616 ! negatively regulates interleukin-13 production property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0032700 name: negative regulation of interleukin-17 production namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of production of any member of the interleukin-17 family of cytokines." [GOC:add, GOC:mah, PMID:16482511] synonym: "down regulation of interleukin-17 production" EXACT [] synonym: "downregulation of interleukin-17 production" EXACT [] synonym: "inhibition of interleukin-17 production" NARROW [] synonym: "negative regulation of CTLA-8 production" NARROW [GOC:TermGenie] synonym: "negative regulation of Cytotoxic T-lymphocyte-associated antigen 8 secretion" EXACT [GOC:TermGenie] synonym: "negative regulation of IL-17 production" EXACT [] synonym: "negative regulation of interleukin-17 biosynthetic process" NARROW [] synonym: "negative regulation of interleukin-17 secretion" NARROW [] is_a: GO:0001818 ! negative regulation of cytokine production is_a: GO:0032660 ! regulation of interleukin-17 production intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0032620 ! negatively regulates interleukin-17 production relationship: RO:0002212 GO:0032620 ! negatively regulates interleukin-17 production property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0032703 name: negative regulation of interleukin-2 production namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-2 production." [GOC:mah] synonym: "down regulation of interleukin-2 production" EXACT [] synonym: "down-regulation of interleukin-2 production" EXACT [] synonym: "downregulation of interleukin-2 production" EXACT [] synonym: "inhibition of interleukin-2 production" NARROW [] synonym: "negative regulation of IL-2 production" EXACT [] synonym: "negative regulation of interleukin-2 biosynthetic process" NARROW [] synonym: "negative regulation of interleukin-2 secretion" NARROW [] is_a: GO:0001818 ! negative regulation of cytokine production is_a: GO:0032663 ! regulation of interleukin-2 production intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0032623 ! negatively regulates interleukin-2 production relationship: RO:0002212 GO:0032623 ! negatively regulates interleukin-2 production property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0032706 name: negative regulation of interleukin-22 production namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-22 production." [GOC:mah] synonym: "down regulation of interleukin-22 production" EXACT [] synonym: "down-regulation of interleukin-22 production" EXACT [] synonym: "downregulation of interleukin-22 production" EXACT [] synonym: "inhibition of interleukin-22 production" NARROW [] synonym: "negative regulation of IL-22 production" EXACT [] synonym: "negative regulation of interleukin-22 biosynthetic process" NARROW [] is_a: GO:0001818 ! negative regulation of cytokine production is_a: GO:0032666 ! regulation of interleukin-22 production intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0032626 ! negatively regulates interleukin-22 production relationship: RO:0002212 GO:0032626 ! negatively regulates interleukin-22 production property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0032713 name: negative regulation of interleukin-4 production namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-4 production." [GOC:mah, PMID:29778524] synonym: "down regulation of interleukin-4 production" EXACT [] synonym: "down-regulation of interleukin-4 production" EXACT [] synonym: "downregulation of interleukin-4 production" EXACT [] synonym: "inhibition of interleukin-4 production" NARROW [] synonym: "negative regulation of IL-4 production" EXACT [] synonym: "negative regulation of interleukin-4 biosynthetic process" NARROW [] synonym: "negative regulation of interleukin-4 secretion" NARROW [] is_a: GO:0001818 ! negative regulation of cytokine production is_a: GO:0032673 ! regulation of interleukin-4 production intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0032633 ! negatively regulates interleukin-4 production relationship: RO:0002212 GO:0032633 ! negatively regulates interleukin-4 production property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0032714 name: negative regulation of interleukin-5 production namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-5 production." [GOC:mah] synonym: "down regulation of interleukin-5 production" EXACT [] synonym: "down-regulation of interleukin-5 production" EXACT [] synonym: "downregulation of interleukin-5 production" EXACT [] synonym: "inhibition of interleukin-5 production" NARROW [] synonym: "negative regulation of IL-5 production" EXACT [] synonym: "negative regulation of interleukin-5 biosynthetic process" NARROW [] synonym: "negative regulation of interleukin-5 secretion" NARROW [] is_a: GO:0001818 ! negative regulation of cytokine production is_a: GO:0032674 ! regulation of interleukin-5 production intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0032634 ! negatively regulates interleukin-5 production relationship: RO:0002212 GO:0032634 ! negatively regulates interleukin-5 production property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0032715 name: negative regulation of interleukin-6 production namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-6 production." [GOC:mah] synonym: "down regulation of interleukin-6 production" EXACT [] synonym: "down-regulation of interleukin-6 production" EXACT [] synonym: "downregulation of interleukin-6 production" EXACT [] synonym: "inhibition of interleukin-6 production" NARROW [] synonym: "negative regulation of IL-6 production" EXACT [] synonym: "negative regulation of interleukin-6 biosynthetic process" NARROW [] synonym: "negative regulation of interleukin-6 secretion" NARROW [] is_a: GO:0001818 ! negative regulation of cytokine production is_a: GO:0032675 ! regulation of interleukin-6 production intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0032635 ! negatively regulates interleukin-6 production relationship: RO:0002212 GO:0032635 ! negatively regulates interleukin-6 production property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0032717 name: negative regulation of interleukin-8 production namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-8 production." [GOC:mah] synonym: "down regulation of interleukin-8 production" EXACT [] synonym: "down-regulation of interleukin-8 production" EXACT [] synonym: "downregulation of interleukin-8 production" EXACT [] synonym: "inhibition of interleukin-8 production" NARROW [] synonym: "negative regulation of IL-8 production" EXACT [] synonym: "negative regulation of interleukin-8 biosynthetic process" NARROW [] synonym: "negative regulation of interleukin-8 secretion" NARROW [] is_a: GO:0001818 ! negative regulation of cytokine production is_a: GO:0032677 ! regulation of interleukin-8 production intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0032637 ! negatively regulates interleukin-8 production relationship: RO:0002212 GO:0032637 ! negatively regulates interleukin-8 production property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0032718 name: negative regulation of interleukin-9 production namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-9 production." [GOC:mah] synonym: "down regulation of interleukin-9 production" EXACT [] synonym: "down-regulation of interleukin-9 production" EXACT [] synonym: "downregulation of interleukin-9 production" EXACT [] synonym: "inhibition of interleukin-9 production" NARROW [] synonym: "negative regulation of IL-9 production" EXACT [] synonym: "negative regulation of interleukin-9 biosynthetic process" NARROW [] is_a: GO:0001818 ! negative regulation of cytokine production is_a: GO:0032678 ! regulation of interleukin-9 production intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0032638 ! negatively regulates interleukin-9 production relationship: RO:0002212 GO:0032638 ! negatively regulates interleukin-9 production property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0032720 name: negative regulation of tumor necrosis factor production namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of tumor necrosis factor production." [GOC:mah, PMID:10891884, PMID:15560120] comment: Note that this term refers only to the specific, original 'tumor necrosis factor' protein (TNF) and not other members of the tumor necrosis factor superfamily (those with the gene symbol root 'TNFSF'). synonym: "down regulation of tumor necrosis factor production" EXACT [] synonym: "down-regulation of tumor necrosis factor production" EXACT [] synonym: "downregulation of tumor necrosis factor production" EXACT [] synonym: "inhibition of cachectin production" NARROW [GOC:TermGenie] synonym: "inhibition of tumor necrosis factor production" NARROW [] synonym: "negative regulation of tumor necrosis factor biosynthetic process" NARROW [] synonym: "negative regulation of tumor necrosis factor secretion" NARROW [] synonym: "negative regulation TNF production" EXACT [] synonym: "negative regulation TNF-alpha production" EXACT [] synonym: "negative regulation tumor necrosis factor-alpha production" EXACT [] is_a: GO:0032680 ! regulation of tumor necrosis factor production is_a: GO:1903556 ! negative regulation of tumor necrosis factor superfamily cytokine production intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0032640 ! negatively regulates tumor necrosis factor production relationship: RO:0002212 GO:0032640 ! negatively regulates tumor necrosis factor production property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 creation_date: 2015-07-09T19:50:08Z [Term] id: GO:0032729 name: positive regulation of type II interferon production namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of interferon-gamma production. Interferon-gamma is also known as type II interferon." [GOC:add, GOC:mah, PMID:15546383] synonym: "activation of interferon-gamma production" NARROW [] synonym: "positive regulation of interferon-gamma biosynthetic process" NARROW [] synonym: "positive regulation of interferon-gamma production" EXACT [] synonym: "positive regulation of interferon-gamma secretion" NARROW [] synonym: "stimulation of interferon-gamma production" NARROW [] synonym: "up regulation of interferon-gamma production" EXACT [] synonym: "up-regulation of interferon-gamma production" EXACT [] synonym: "upregulation of interferon-gamma production" EXACT [] is_a: GO:0001819 ! positive regulation of cytokine production is_a: GO:0032649 ! regulation of type II interferon production intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0032609 ! positively regulates type II interferon production relationship: RO:0002162 NCBITaxon:6072 ! in taxon Eumetazoa relationship: RO:0002213 GO:0032609 ! positively regulates type II interferon production [Term] id: GO:0032731 name: positive regulation of interleukin-1 beta production namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of interleukin-1 beta production." [GOC:mah] synonym: "activation of interleukin-1 beta production" NARROW [] synonym: "positive regulation of IL-1 beta production" EXACT [] synonym: "positive regulation of interleukin-1 beta biosynthetic process" NARROW [] synonym: "positive regulation of interleukin-1 beta secretion" NARROW [] synonym: "stimulation of interleukin-1 beta production" NARROW [] synonym: "up regulation of interleukin-1 beta production" EXACT [] synonym: "up-regulation of interleukin-1 beta production" EXACT [] synonym: "upregulation of interleukin-1 beta production" EXACT [] is_a: GO:0032651 ! regulation of interleukin-1 beta production is_a: GO:0032732 ! positive regulation of interleukin-1 production intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0032611 ! positively regulates interleukin-1 beta production relationship: RO:0002213 GO:0032611 ! positively regulates interleukin-1 beta production property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0032732 name: positive regulation of interleukin-1 production namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of interleukin-1 production." [GOC:mah] synonym: "activation of interleukin-1 production" NARROW [] synonym: "positive regulation of IL-1 production" EXACT [] synonym: "positive regulation of interleukin-1 biosynthetic process" NARROW [] synonym: "positive regulation of interleukin-1 secretion" NARROW [] synonym: "stimulation of interleukin-1 production" NARROW [] synonym: "up regulation of interleukin-1 production" EXACT [] synonym: "up-regulation of interleukin-1 production" EXACT [] synonym: "upregulation of interleukin-1 production" EXACT [] is_a: GO:0001819 ! positive regulation of cytokine production is_a: GO:0032652 ! regulation of interleukin-1 production intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0032612 ! positively regulates interleukin-1 production relationship: RO:0002213 GO:0032612 ! positively regulates interleukin-1 production property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0032733 name: positive regulation of interleukin-10 production namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of interleukin-10 production." [GOC:mah] synonym: "activation of interleukin-10 production" NARROW [] synonym: "positive regulation of IL-10 production" EXACT [] synonym: "positive regulation of interleukin-10 biosynthetic process" NARROW [] synonym: "positive regulation of interleukin-10 secretion" NARROW [] synonym: "stimulation of interleukin-10 production" NARROW [] synonym: "up regulation of interleukin-10 production" EXACT [] synonym: "up-regulation of interleukin-10 production" EXACT [] synonym: "upregulation of interleukin-10 production" EXACT [] is_a: GO:0001819 ! positive regulation of cytokine production is_a: GO:0032653 ! regulation of interleukin-10 production intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0032613 ! positively regulates interleukin-10 production relationship: RO:0002213 GO:0032613 ! positively regulates interleukin-10 production property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0032736 name: positive regulation of interleukin-13 production namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of interleukin-13 production." [GOC:mah] synonym: "activation of interleukin-13 production" NARROW [] synonym: "positive regulation of IL-13 production" EXACT [] synonym: "positive regulation of interleukin-13 biosynthetic process" NARROW [] synonym: "positive regulation of interleukin-13 secretion" NARROW [] synonym: "stimulation of interleukin-13 production" NARROW [] synonym: "up regulation of interleukin-13 production" EXACT [] synonym: "up-regulation of interleukin-13 production" EXACT [] synonym: "upregulation of interleukin-13 production" EXACT [] is_a: GO:0001819 ! positive regulation of cytokine production is_a: GO:0032656 ! regulation of interleukin-13 production intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0032616 ! positively regulates interleukin-13 production relationship: RO:0002213 GO:0032616 ! positively regulates interleukin-13 production property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0032740 name: positive regulation of interleukin-17 production namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of production of any member of the interleukin-17 family of cytokines." [GOC:add, GOC:mah, PMID:16482511] synonym: "activation of interleukin-17 production" NARROW [] synonym: "positive regulation of CTLA-8 production" EXACT [GOC:TermGenie] synonym: "positive regulation of Cytotoxic T-lymphocyte-associated antigen 8 production" EXACT [GOC:TermGenie] synonym: "positive regulation of IL-17 production" EXACT [] synonym: "positive regulation of interleukin-17 biosynthetic process" NARROW [] synonym: "positive regulation of interleukin-17 secretion" NARROW [] synonym: "stimulation of interleukin-17 production" NARROW [] synonym: "up regulation of interleukin-17 production" EXACT [] synonym: "up-regulation of interleukin-17 production" EXACT [] synonym: "upregulation of interleukin-17 production" EXACT [] is_a: GO:0001819 ! positive regulation of cytokine production is_a: GO:0032660 ! regulation of interleukin-17 production intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0032620 ! positively regulates interleukin-17 production relationship: RO:0002213 GO:0032620 ! positively regulates interleukin-17 production property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0032743 name: positive regulation of interleukin-2 production namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of interleukin-2 production." [GOC:mah] synonym: "activation of interleukin-2 production" NARROW [] synonym: "positive regulation of IL-2 production" EXACT [] synonym: "positive regulation of interleukin-2 biosynthetic process" NARROW [] synonym: "positive regulation of interleukin-2 secretion" NARROW [] synonym: "stimulation of interleukin-2 production" NARROW [] synonym: "up regulation of interleukin-2 production" EXACT [] synonym: "up-regulation of interleukin-2 production" EXACT [] synonym: "upregulation of interleukin-2 production" EXACT [] is_a: GO:0001819 ! positive regulation of cytokine production is_a: GO:0032663 ! regulation of interleukin-2 production intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0032623 ! positively regulates interleukin-2 production relationship: RO:0002213 GO:0032623 ! positively regulates interleukin-2 production property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0032746 name: positive regulation of interleukin-22 production namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of interleukin-22 production." [GOC:mah] synonym: "activation of interleukin-22 production" NARROW [] synonym: "positive regulation of IL-22 production" EXACT [] synonym: "positive regulation of interleukin-22 biosynthetic process" NARROW [] synonym: "stimulation of interleukin-22 production" NARROW [] synonym: "up regulation of interleukin-22 production" EXACT [] synonym: "up-regulation of interleukin-22 production" EXACT [] synonym: "upregulation of interleukin-22 production" EXACT [] is_a: GO:0001819 ! positive regulation of cytokine production is_a: GO:0032666 ! regulation of interleukin-22 production intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0032626 ! positively regulates interleukin-22 production relationship: RO:0002213 GO:0032626 ! positively regulates interleukin-22 production property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0032753 name: positive regulation of interleukin-4 production namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of interleukin-4 production." [GOC:mah] synonym: "activation of interleukin-4 production" NARROW [] synonym: "positive regulation of IL-4 production" EXACT [] synonym: "positive regulation of interleukin-4 biosynthetic process" NARROW [] synonym: "positive regulation of interleukin-4 secretion" NARROW [] synonym: "stimulation of interleukin-4 production" NARROW [] synonym: "up regulation of interleukin-4 production" EXACT [] synonym: "up-regulation of interleukin-4 production" EXACT [] synonym: "upregulation of interleukin-4 production" EXACT [] is_a: GO:0001819 ! positive regulation of cytokine production is_a: GO:0032673 ! regulation of interleukin-4 production intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0032633 ! positively regulates interleukin-4 production relationship: RO:0002213 GO:0032633 ! positively regulates interleukin-4 production property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0032754 name: positive regulation of interleukin-5 production namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of interleukin-5 production." [GOC:mah] synonym: "activation of interleukin-5 production" NARROW [] synonym: "positive regulation of IL-5 production" EXACT [] synonym: "positive regulation of interleukin-5 biosynthetic process" NARROW [] synonym: "positive regulation of interleukin-5 secretion" NARROW [] synonym: "stimulation of interleukin-5 production" NARROW [] synonym: "up regulation of interleukin-5 production" EXACT [] synonym: "up-regulation of interleukin-5 production" EXACT [] synonym: "upregulation of interleukin-5 production" EXACT [] is_a: GO:0001819 ! positive regulation of cytokine production is_a: GO:0032674 ! regulation of interleukin-5 production intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0032634 ! positively regulates interleukin-5 production relationship: RO:0002213 GO:0032634 ! positively regulates interleukin-5 production property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0032755 name: positive regulation of interleukin-6 production namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of interleukin-6 production." [GOC:mah] synonym: "activation of interleukin-6 production" NARROW [] synonym: "positive regulation of IL-6 production" EXACT [] synonym: "positive regulation of interleukin-6 biosynthetic process" NARROW [] synonym: "positive regulation of interleukin-6 secretion" NARROW [] synonym: "stimulation of interleukin-6 production" NARROW [] synonym: "up regulation of interleukin-6 production" EXACT [] synonym: "up-regulation of interleukin-6 production" EXACT [] synonym: "upregulation of interleukin-6 production" EXACT [] is_a: GO:0001819 ! positive regulation of cytokine production is_a: GO:0032675 ! regulation of interleukin-6 production intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0032635 ! positively regulates interleukin-6 production relationship: RO:0002162 NCBITaxon:6072 ! in taxon Eumetazoa relationship: RO:0002213 GO:0032635 ! positively regulates interleukin-6 production [Term] id: GO:0032757 name: positive regulation of interleukin-8 production namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of interleukin-8 production." [GOC:mah] synonym: "activation of interleukin-8 production" NARROW [] synonym: "positive regulation of IL-8 production" EXACT [] synonym: "positive regulation of interleukin-8 biosynthetic process" NARROW [] synonym: "positive regulation of interleukin-8 secretion" NARROW [] synonym: "stimulation of interleukin-8 production" NARROW [] synonym: "up regulation of interleukin-8 production" EXACT [] synonym: "up-regulation of interleukin-8 production" EXACT [] synonym: "upregulation of interleukin-8 production" EXACT [] is_a: GO:0001819 ! positive regulation of cytokine production is_a: GO:0032677 ! regulation of interleukin-8 production intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0032637 ! positively regulates interleukin-8 production relationship: RO:0002213 GO:0032637 ! positively regulates interleukin-8 production property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0032758 name: positive regulation of interleukin-9 production namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of interleukin-9 production." [GOC:mah] synonym: "activation of interleukin-9 production" NARROW [] synonym: "positive regulation of IL-9 production" EXACT [] synonym: "positive regulation of interleukin-9 biosynthetic process" NARROW [] synonym: "stimulation of interleukin-9 production" NARROW [] synonym: "up regulation of interleukin-9 production" EXACT [] synonym: "up-regulation of interleukin-9 production" EXACT [] synonym: "upregulation of interleukin-9 production" EXACT [] is_a: GO:0001819 ! positive regulation of cytokine production is_a: GO:0032678 ! regulation of interleukin-9 production intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0032638 ! positively regulates interleukin-9 production relationship: RO:0002213 GO:0032638 ! positively regulates interleukin-9 production property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0032760 name: positive regulation of tumor necrosis factor production namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of tumor necrosis factor production." [GO_REF:0000058, GOC:TermGenie, PMID:10891884, PMID:15560120] comment: Note that this term refers only to the specific, original 'tumor necrosis factor' protein (TNF) and not other members of the tumor necrosis factor superfamily (those with the gene symbol root 'TNFSF'). synonym: "activation of tumor necrosis factor production" NARROW [] synonym: "positive regulation of cachectin secretion" NARROW [GOC:TermGenie] synonym: "positive regulation of TNF production" EXACT [] synonym: "positive regulation of TNF secretion" NARROW [GOC:TermGenie] synonym: "positive regulation of TNF-alpha production" EXACT [] synonym: "positive regulation of tumor necrosis factor biosynthesis" NARROW [] synonym: "positive regulation of tumor necrosis factor biosynthetic process" NARROW [] synonym: "positive regulation of tumor necrosis factor formation" NARROW [] synonym: "positive regulation of tumor necrosis factor secretion" NARROW [] synonym: "positive regulation of tumor necrosis factor-alpha production" EXACT [] synonym: "stimulation of tumor necrosis factor production" NARROW [] synonym: "up regulation of tumor necrosis factor production" EXACT [] synonym: "up-regulation of tumor necrosis factor production" EXACT [] synonym: "upregulation of tumor necrosis factor production" EXACT [] is_a: GO:0032680 ! regulation of tumor necrosis factor production is_a: GO:1903557 ! positive regulation of tumor necrosis factor superfamily cytokine production intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0032640 ! positively regulates tumor necrosis factor production relationship: RO:0002213 GO:0032640 ! positively regulates tumor necrosis factor production property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 creation_date: 2015-07-09T19:50:14Z [Term] id: GO:0032762 name: mast cell cytokine production namespace: biological_process def: "Any process that contributes to cytokine production by a mast cell." [GOC:mah] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms. subset: gocheck_do_not_annotate is_a: GO:0061082 ! myeloid leukocyte cytokine production intersection_of: GO:0001816 ! cytokine production intersection_of: BFO:0000066 CL:0000097 ! occurs in mast cell relationship: BFO:0000066 CL:0000097 ! occurs in mast cell property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4895 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0032763 name: regulation of mast cell cytokine production namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of mast cell cytokine production." [GOC:mah] is_a: GO:0002718 ! regulation of cytokine production involved in immune response intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0032762 ! regulates mast cell cytokine production relationship: RO:0002211 GO:0032762 ! regulates mast cell cytokine production property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4895 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0032764 name: negative regulation of mast cell cytokine production namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of mast cell cytokine production." [GOC:mah] synonym: "down regulation of mast cell cytokine production" EXACT [] synonym: "down-regulation of mast cell cytokine production" EXACT [] synonym: "downregulation of mast cell cytokine production" EXACT [] synonym: "inhibition of mast cell cytokine production" NARROW [] is_a: GO:0002719 ! negative regulation of cytokine production involved in immune response is_a: GO:0032763 ! regulation of mast cell cytokine production intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0032762 ! negatively regulates mast cell cytokine production relationship: RO:0002212 GO:0032762 ! negatively regulates mast cell cytokine production property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4895 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0032765 name: positive regulation of mast cell cytokine production namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of mast cell cytokine production." [GOC:mah] synonym: "activation of mast cell cytokine production" NARROW [] synonym: "stimulation of mast cell cytokine production" NARROW [] synonym: "up regulation of mast cell cytokine production" EXACT [] synonym: "up-regulation of mast cell cytokine production" EXACT [] synonym: "upregulation of mast cell cytokine production" EXACT [] is_a: GO:0032763 ! regulation of mast cell cytokine production is_a: GO:0061081 ! positive regulation of myeloid leukocyte cytokine production involved in immune response intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0032762 ! positively regulates mast cell cytokine production relationship: RO:0002213 GO:0032762 ! positively regulates mast cell cytokine production property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4895 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0032774 name: RNA biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage. Includes polymerization of ribonucleotide monomers. Refers not only to transcription but also to e.g. viral RNA replication." [GOC:mah, GOC:txnOH] comment: Note that, in some cases, viral RNA replication and viral transcription from RNA actually refer to the same process, but may be called differently depending on the focus of a specific research study. subset: gocheck_do_not_annotate synonym: "double-stranded RNA biosynthesis" NARROW [] synonym: "double-stranded RNA biosynthetic process" NARROW [] synonym: "dsRNA biosynthesis" NARROW [] synonym: "dsRNA biosynthetic process" NARROW [GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:rl] synonym: "RNA anabolism" EXACT [] synonym: "RNA biosynthesis" EXACT [] synonym: "RNA formation" EXACT [] synonym: "RNA synthesis" EXACT [] is_a: GO:0016070 ! RNA metabolic process is_a: GO:0141187 ! nucleic acid biosynthetic process intersection_of: GO:0009059 ! macromolecule biosynthetic process intersection_of: RO:0004008 CHEBI:33697 ! has primary output relationship: RO:0004008 CHEBI:33697 ! has primary output [Term] id: GO:0032780 name: negative regulation of ATP-dependent activity namespace: biological_process def: "Any process that stops or reduces the rate of an ATP-dependent activity." [GOC:mah] subset: gocheck_obsoletion_candidate synonym: "down regulation of ATPase activity" EXACT [] synonym: "down-regulation of ATPase activity" EXACT [] synonym: "downregulation of ATPase activity" EXACT [] synonym: "inhibition of ATPase activity" NARROW [] synonym: "negative regulation of adenosinetriphosphatase activity" EXACT [] synonym: "negative regulation of ATPase activity" EXACT [] is_a: GO:0043462 ! regulation of ATP-dependent activity is_a: GO:0044092 ! negative regulation of molecular function intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0140657 ! negatively regulates ATP-dependent activity relationship: RO:0002212 GO:0140657 ! negatively regulates ATP-dependent activity property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/22371" xsd:anyURI [Term] id: GO:0032781 name: positive regulation of ATP-dependent activity namespace: biological_process def: "Any process that activates or increases the rate of an ATP-dependent activity." [GOC:mah] subset: gocheck_obsoletion_candidate synonym: "activation of ATPase activity" NARROW [] synonym: "positive regulation of adenosinetriphosphatase activity" EXACT [] synonym: "positive regulation of ATPase activity" EXACT [] synonym: "stimulation of ATPase activity" NARROW [] synonym: "up regulation of ATPase activity" EXACT [] synonym: "up-regulation of ATPase activity" EXACT [] synonym: "upregulation of ATPase activity" EXACT [] is_a: GO:0043462 ! regulation of ATP-dependent activity is_a: GO:0044093 ! positive regulation of molecular function intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0140657 ! positively regulates ATP-dependent activity relationship: RO:0002213 GO:0140657 ! positively regulates ATP-dependent activity property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/22371" xsd:anyURI [Term] id: GO:0032782 name: bile acid secretion namespace: biological_process def: "The regulated release of bile acid, composed of any of a group of steroid carboxylic acids occurring in bile, by a cell or a tissue." [GOC:ecd] is_a: GO:0015718 ! monocarboxylic acid transport is_a: GO:0046717 ! acid secretion intersection_of: GO:0046903 ! secretion intersection_of: RO:0004009 CHEBI:36235 ! has primary input relationship: RO:0004009 CHEBI:36235 ! has primary input [Term] id: GO:0032787 name: monocarboxylic acid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving monocarboxylic acids, any organic acid containing one carboxyl (COOH) group or anion (COO-)." [GOC:vk] subset: goslim_yeast synonym: "monocarboxylate metabolic process" EXACT [] synonym: "monocarboxylic acid metabolism" EXACT [] is_a: GO:0019752 ! carboxylic acid metabolic process intersection_of: GO:0008152 ! metabolic process intersection_of: RO:0004007 CHEBI:35757 ! has primary input or output relationship: RO:0004007 CHEBI:35757 ! has primary input or output [Term] id: GO:0032790 name: ribosome disassembly namespace: biological_process def: "The disaggregation of a ribosome into its constituent components; includes the dissociation of ribosomal subunits." [GOC:mah, GOC:vk] synonym: "ribosome dissociation factor" RELATED [] synonym: "ribosome recycling" NARROW [GOC:db, PMID:9463391] is_a: GO:1903008 ! organelle disassembly intersection_of: GO:0022411 ! cellular component disassembly intersection_of: RO:0002590 GO:0005840 ! results in disassembly of ribosome relationship: RO:0002590 GO:0005840 ! results in disassembly of ribosome [Term] id: GO:0032808 name: lacrimal gland development namespace: biological_process def: "The process whose specific outcome is the progression of the lacrimal gland over time, from its formation to the mature structure. The lacrimal gland produces secretions that lubricate and protect the cornea of the eye." [GOC:ln] is_a: GO:0048732 ! gland development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0001817 ! results in development of lacrimal gland relationship: BFO:0000050 GO:0035272 ! part of exocrine system development relationship: RO:0002296 UBERON:0001817 ! results in development of lacrimal gland [Term] id: GO:0032811 name: negative regulation of epinephrine secretion namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of epinephrine." [GOC:vk] synonym: "down regulation of epinephrine secretion" EXACT [] synonym: "down-regulation of epinephrine secretion" EXACT [] synonym: "downregulation of epinephrine secretion" EXACT [] synonym: "inhibition of epinephrine secretion" NARROW [] synonym: "negative regulation of adrenaline secretion" EXACT [] is_a: GO:0014060 ! regulation of epinephrine secretion is_a: GO:0033604 ! negative regulation of catecholamine secretion intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0048242 ! negatively regulates epinephrine secretion relationship: RO:0002212 GO:0048242 ! negatively regulates epinephrine secretion [Term] id: GO:0032812 name: positive regulation of epinephrine secretion namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the regulated release of epinephrine." [GOC:vk] synonym: "activation of epinephrine secretion" NARROW [] synonym: "positive regulation of adrenaline secretion" EXACT [] synonym: "stimulation of epinephrine secretion" NARROW [] synonym: "up regulation of epinephrine secretion" EXACT [] synonym: "up-regulation of epinephrine secretion" EXACT [] synonym: "upregulation of epinephrine secretion" EXACT [] is_a: GO:0014060 ! regulation of epinephrine secretion is_a: GO:0033605 ! positive regulation of catecholamine secretion intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0048242 ! positively regulates epinephrine secretion relationship: RO:0002213 GO:0048242 ! positively regulates epinephrine secretion [Term] id: GO:0032814 name: regulation of natural killer cell activation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of natural killer cell activation." [GOC:mah] synonym: "regulation of NK cell activation" EXACT [] is_a: GO:0051249 ! regulation of lymphocyte activation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0030101 ! regulates natural killer cell activation relationship: RO:0002211 GO:0030101 ! regulates natural killer cell activation [Term] id: GO:0032815 name: negative regulation of natural killer cell activation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of natural killer cell activation." [GOC:mah] synonym: "down regulation of natural killer cell activation" EXACT [] synonym: "down-regulation of natural killer cell activation" EXACT [] synonym: "downregulation of natural killer cell activation" EXACT [] synonym: "inhibition of natural killer cell activation" NARROW [] synonym: "negative regulation of NK cell activation" EXACT [] is_a: GO:0032814 ! regulation of natural killer cell activation is_a: GO:0051250 ! negative regulation of lymphocyte activation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0030101 ! negatively regulates natural killer cell activation relationship: RO:0002212 GO:0030101 ! negatively regulates natural killer cell activation [Term] id: GO:0032816 name: positive regulation of natural killer cell activation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of natural killer cell activation." [GOC:mah] synonym: "activation of natural killer cell activation" NARROW [] synonym: "positive regulation of NK cell activation" EXACT [] synonym: "stimulation of natural killer cell activation" NARROW [] synonym: "up regulation of natural killer cell activation" EXACT [] synonym: "up-regulation of natural killer cell activation" EXACT [] synonym: "upregulation of natural killer cell activation" EXACT [] is_a: GO:0032814 ! regulation of natural killer cell activation is_a: GO:0051251 ! positive regulation of lymphocyte activation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0030101 ! positively regulates natural killer cell activation relationship: RO:0002213 GO:0030101 ! positively regulates natural killer cell activation [Term] id: GO:0032817 name: regulation of natural killer cell proliferation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of natural killer cell proliferation." [GOC:mah] synonym: "regulation of NK cell proliferation" EXACT [] is_a: GO:0032814 ! regulation of natural killer cell activation is_a: GO:0050670 ! regulation of lymphocyte proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0001787 ! regulates natural killer cell proliferation relationship: RO:0002211 GO:0001787 ! regulates natural killer cell proliferation [Term] id: GO:0032818 name: negative regulation of natural killer cell proliferation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of natural killer cell proliferation." [GOC:mah] synonym: "down regulation of natural killer cell proliferation" EXACT [] synonym: "down-regulation of natural killer cell proliferation" EXACT [] synonym: "downregulation of natural killer cell proliferation" EXACT [] synonym: "inhibition of natural killer cell proliferation" NARROW [] synonym: "negative regulation of NK cell proliferation" EXACT [] is_a: GO:0032815 ! negative regulation of natural killer cell activation is_a: GO:0032817 ! regulation of natural killer cell proliferation is_a: GO:0050672 ! negative regulation of lymphocyte proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0001787 ! negatively regulates natural killer cell proliferation relationship: RO:0002212 GO:0001787 ! negatively regulates natural killer cell proliferation [Term] id: GO:0032819 name: positive regulation of natural killer cell proliferation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of natural killer cell proliferation." [GOC:mah] synonym: "activation of natural killer cell proliferation" NARROW [] synonym: "positive regulation of NK cell proliferation" EXACT [] synonym: "stimulation of natural killer cell proliferation" NARROW [] synonym: "up regulation of natural killer cell proliferation" EXACT [] synonym: "up-regulation of natural killer cell proliferation" EXACT [] synonym: "upregulation of natural killer cell proliferation" EXACT [] is_a: GO:0032816 ! positive regulation of natural killer cell activation is_a: GO:0032817 ! regulation of natural killer cell proliferation is_a: GO:0050671 ! positive regulation of lymphocyte proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0001787 ! positively regulates natural killer cell proliferation relationship: RO:0002213 GO:0001787 ! positively regulates natural killer cell proliferation [Term] id: GO:0032820 name: regulation of natural killer cell proliferation involved in immune response namespace: biological_process def: "Any process that modulates the frequency, rate or extent of natural killer cell proliferation as part of an immune response." [GOC:mah] synonym: "regulation of natural killer cell proliferation during immune response" RELATED [GOC:tb] synonym: "regulation of NK cell proliferation during immune response" RELATED [] is_a: GO:0002697 ! regulation of immune effector process is_a: GO:0032817 ! regulation of natural killer cell proliferation is_a: GO:0050776 ! regulation of immune response intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0002324 ! regulates natural killer cell proliferation involved in immune response relationship: RO:0002211 GO:0002324 ! regulates natural killer cell proliferation involved in immune response [Term] id: GO:0032821 name: negative regulation of natural killer cell proliferation involved in immune response namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of natural killer cell proliferation as part of an immune response." [GOC:mah] synonym: "down regulation of natural killer cell proliferation during immune response" RELATED [] synonym: "down-regulation of natural killer cell proliferation during immune response" RELATED [] synonym: "downregulation of natural killer cell proliferation during immune response" RELATED [] synonym: "inhibition of natural killer cell proliferation during immune response" NARROW [] synonym: "negative regulation of natural killer cell proliferation during immune response" RELATED [GOC:tb] synonym: "negative regulation of NK cell proliferation during immune response" RELATED [] is_a: GO:0002698 ! negative regulation of immune effector process is_a: GO:0032818 ! negative regulation of natural killer cell proliferation is_a: GO:0032820 ! regulation of natural killer cell proliferation involved in immune response is_a: GO:0050777 ! negative regulation of immune response intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0002324 ! negatively regulates natural killer cell proliferation involved in immune response relationship: RO:0002212 GO:0002324 ! negatively regulates natural killer cell proliferation involved in immune response [Term] id: GO:0032822 name: positive regulation of natural killer cell proliferation involved in immune response namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of natural killer cell proliferation as part of an immune response." [GOC:mah] synonym: "activation of natural killer cell proliferation during immune response" NARROW [] synonym: "positive regulation of natural killer cell proliferation during immune response" RELATED [GOC:tb] synonym: "positive regulation of NK cell proliferation during immune response" RELATED [] synonym: "stimulation of natural killer cell proliferation during immune response" NARROW [] synonym: "up regulation of natural killer cell proliferation during immune response" RELATED [] synonym: "up-regulation of natural killer cell proliferation during immune response" RELATED [] synonym: "upregulation of natural killer cell proliferation during immune response" RELATED [] is_a: GO:0002699 ! positive regulation of immune effector process is_a: GO:0032819 ! positive regulation of natural killer cell proliferation is_a: GO:0032820 ! regulation of natural killer cell proliferation involved in immune response intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0002324 ! positively regulates natural killer cell proliferation involved in immune response relationship: RO:0002213 GO:0002324 ! positively regulates natural killer cell proliferation involved in immune response [Term] id: GO:0032823 name: regulation of natural killer cell differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of natural killer cell differentiation." [GOC:mah] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "regulation of natural killer cell development" RELATED [GOC:add] synonym: "regulation of NK cell differentiation" EXACT [] is_a: GO:0032814 ! regulation of natural killer cell activation is_a: GO:0045619 ! regulation of lymphocyte differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0001779 ! regulates natural killer cell differentiation relationship: RO:0002211 GO:0001779 ! regulates natural killer cell differentiation [Term] id: GO:0032824 name: negative regulation of natural killer cell differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of natural killer cell differentiation." [GOC:mah] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "down regulation of natural killer cell differentiation" EXACT [] synonym: "down-regulation of natural killer cell differentiation" EXACT [] synonym: "downregulation of natural killer cell differentiation" EXACT [] synonym: "inhibition of natural killer cell differentiation" NARROW [] synonym: "negative regulation of natural killer cell development" RELATED [GOC:add] synonym: "negative regulation of NK cell differentiation" EXACT [] is_a: GO:0032815 ! negative regulation of natural killer cell activation is_a: GO:0032823 ! regulation of natural killer cell differentiation is_a: GO:0045620 ! negative regulation of lymphocyte differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0001779 ! negatively regulates natural killer cell differentiation relationship: RO:0002212 GO:0001779 ! negatively regulates natural killer cell differentiation [Term] id: GO:0032825 name: positive regulation of natural killer cell differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of natural killer cell differentiation." [GOC:mah] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "activation of natural killer cell differentiation" NARROW [] synonym: "positive regulation of natural killer cell development" RELATED [GOC:add] synonym: "positive regulation of NK cell differentiation" EXACT [] synonym: "stimulation of natural killer cell differentiation" NARROW [] synonym: "up regulation of natural killer cell differentiation" EXACT [] synonym: "up-regulation of natural killer cell differentiation" EXACT [] synonym: "upregulation of natural killer cell differentiation" EXACT [] is_a: GO:0032816 ! positive regulation of natural killer cell activation is_a: GO:0032823 ! regulation of natural killer cell differentiation is_a: GO:0045621 ! positive regulation of lymphocyte differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0001779 ! positively regulates natural killer cell differentiation relationship: RO:0002213 GO:0001779 ! positively regulates natural killer cell differentiation [Term] id: GO:0032826 name: regulation of natural killer cell differentiation involved in immune response namespace: biological_process def: "Any process that modulates the frequency, rate or extent of natural killer cell differentiation as part of an immune response." [GOC:mah] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "regulation of natural killer cell development involved in immune response" RELATED [GOC:add] synonym: "regulation of natural killer cell differentiation during immune response" RELATED [GOC:tb] synonym: "regulation of NK cell differentiation during immune response" RELATED [] is_a: GO:0002697 ! regulation of immune effector process is_a: GO:0032823 ! regulation of natural killer cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0002325 ! regulates natural killer cell differentiation involved in immune response relationship: RO:0002211 GO:0002325 ! regulates natural killer cell differentiation involved in immune response [Term] id: GO:0032827 name: negative regulation of natural killer cell differentiation involved in immune response namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of natural killer cell differentiation as part of an immune response." [GOC:mah] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "down regulation of natural killer cell differentiation during immune response" RELATED [] synonym: "down-regulation of natural killer cell differentiation during immune response" RELATED [] synonym: "downregulation of natural killer cell differentiation during immune response" RELATED [] synonym: "inhibition of natural killer cell differentiation during immune response" NARROW [] synonym: "negative regulation of natural killer cell development involved in immune response" RELATED [GOC:add] synonym: "negative regulation of natural killer cell differentiation during immune response" RELATED [GOC:tb] synonym: "negative regulation of NK cell differentiation during immune response" RELATED [] is_a: GO:0002698 ! negative regulation of immune effector process is_a: GO:0032824 ! negative regulation of natural killer cell differentiation is_a: GO:0032826 ! regulation of natural killer cell differentiation involved in immune response is_a: GO:0050777 ! negative regulation of immune response intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0002325 ! negatively regulates natural killer cell differentiation involved in immune response relationship: RO:0002212 GO:0002325 ! negatively regulates natural killer cell differentiation involved in immune response [Term] id: GO:0032828 name: positive regulation of natural killer cell differentiation involved in immune response namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of natural killer cell differentiation as part of an immune response." [GOC:mah] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "activation of natural killer cell differentiation during immune response" NARROW [] synonym: "positive regulation of natural killer cell development involved in immune response" RELATED [GOC:add] synonym: "positive regulation of natural killer cell differentiation during immune response" RELATED [GOC:tb] synonym: "positive regulation of NK cell differentiation during immune response" RELATED [] synonym: "stimulation of natural killer cell differentiation during immune response" NARROW [] synonym: "up regulation of natural killer cell differentiation during immune response" RELATED [] synonym: "up-regulation of natural killer cell differentiation during immune response" RELATED [] synonym: "upregulation of natural killer cell differentiation during immune response" RELATED [] is_a: GO:0002699 ! positive regulation of immune effector process is_a: GO:0032825 ! positive regulation of natural killer cell differentiation is_a: GO:0032826 ! regulation of natural killer cell differentiation involved in immune response is_a: GO:0050778 ! positive regulation of immune response intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0002325 ! positively regulates natural killer cell differentiation involved in immune response relationship: RO:0002213 GO:0002325 ! positively regulates natural killer cell differentiation involved in immune response [Term] id: GO:0032829 name: regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of differentiation of CD4-positive, CD25-positive, alpha-beta regulatory T cells." [GOC:mah] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell development" RELATED [GOC:add] synonym: "regulation of CD4-positive, CD25-positive, alpha-beta regulatory T lymphocyte differentiation" EXACT [] synonym: "regulation of CD4-positive, CD25-positive, alpha-beta regulatory T-cell differentiation" EXACT [] synonym: "regulation of CD4-positive, CD25-positive, alpha-beta regulatory T-lymphocyte differentiation" EXACT [] is_a: GO:0043370 ! regulation of CD4-positive, alpha-beta T cell differentiation is_a: GO:0045589 ! regulation of regulatory T cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0002361 ! regulates CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation relationship: RO:0002211 GO:0002361 ! regulates CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation [Term] id: GO:0032830 name: negative regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of differentiation of CD4-positive, CD25-positive, alpha-beta regulatory T cells." [GOC:mah] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "down regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation" EXACT [] synonym: "down-regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation" EXACT [] synonym: "downregulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation" EXACT [] synonym: "inhibition of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation" NARROW [] synonym: "negative regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell development" RELATED [GOC:add] synonym: "negative regulation of CD4-positive, CD25-positive, alpha-beta regulatory T lymphocyte differentiation" EXACT [] synonym: "negative regulation of CD4-positive, CD25-positive, alpha-beta regulatory T-cell differentiation" EXACT [] synonym: "negative regulation of CD4-positive, CD25-positive, alpha-beta regulatory T-lymphocyte differentiation" EXACT [] is_a: GO:0032829 ! regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation is_a: GO:0043371 ! negative regulation of CD4-positive, alpha-beta T cell differentiation is_a: GO:0045590 ! negative regulation of regulatory T cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0002361 ! negatively regulates CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation relationship: RO:0002212 GO:0002361 ! negatively regulates CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation [Term] id: GO:0032831 name: positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of differentiation of CD4-positive, CD25-positive, alpha-beta regulatory T cells." [GOC:mah] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "activation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation" NARROW [] synonym: "positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell development" RELATED [GOC:add] synonym: "positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T lymphocyte differentiation" EXACT [] synonym: "positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T-cell differentiation" EXACT [] synonym: "positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T-lymphocyte differentiation" EXACT [] synonym: "stimulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation" NARROW [] synonym: "up regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation" EXACT [] synonym: "up-regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation" EXACT [] synonym: "upregulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation" EXACT [] is_a: GO:0032829 ! regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation is_a: GO:0043372 ! positive regulation of CD4-positive, alpha-beta T cell differentiation is_a: GO:0045591 ! positive regulation of regulatory T cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0002361 ! positively regulates CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation relationship: RO:0002213 GO:0002361 ! positively regulates CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation [Term] id: GO:0032832 name: regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response namespace: biological_process def: "Any process that modulates the frequency, rate or extent of differentiation of CD4-positive, CD25-positive, alpha-beta regulatory T cells as part of an immune response." [GOC:mah] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell development involved in immune response" RELATED [GOC:add] synonym: "regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation during immune response" RELATED [GOC:tb] synonym: "regulation of CD4-positive, CD25-positive, alpha-beta regulatory T lymphocyte differentiation during immune response" RELATED [] synonym: "regulation of CD4-positive, CD25-positive, alpha-beta regulatory T-cell differentiation during immune response" RELATED [] synonym: "regulation of CD4-positive, CD25-positive, alpha-beta regulatory T-lymphocyte differentiation during immune response" RELATED [] is_a: GO:0002697 ! regulation of immune effector process is_a: GO:0032829 ! regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation is_a: GO:0050776 ! regulation of immune response intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0002298 ! regulates CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response relationship: RO:0002211 GO:0002298 ! regulates CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response [Term] id: GO:0032833 name: negative regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of differentiation of CD4-positive, CD25-positive, alpha-beta regulatory T cells as part of an immune response." [GOC:mah] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "down regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation during immune response" RELATED [] synonym: "down-regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation during immune response" RELATED [] synonym: "downregulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation during immune response" RELATED [] synonym: "inhibition of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation during immune response" NARROW [] synonym: "negative regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell development involved in immune response" RELATED [GOC:add] synonym: "negative regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation during immune response" RELATED [GOC:tb] synonym: "negative regulation of CD4-positive, CD25-positive, alpha-beta regulatory T lymphocyte differentiation during immune response" RELATED [] synonym: "negative regulation of CD4-positive, CD25-positive, alpha-beta regulatory T-cell differentiation during immune response" RELATED [] synonym: "negative regulation of CD4-positive, CD25-positive, alpha-beta regulatory T-lymphocyte differentiation during immune response" RELATED [] is_a: GO:0002698 ! negative regulation of immune effector process is_a: GO:0032830 ! negative regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation is_a: GO:0032832 ! regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response is_a: GO:0050777 ! negative regulation of immune response intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0002298 ! negatively regulates CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response relationship: RO:0002212 GO:0002298 ! negatively regulates CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response [Term] id: GO:0032834 name: positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of differentiation of CD4-positive, CD25-positive, alpha-beta regulatory T cells as part of an immune response." [GOC:mah] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "activation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation during immune response" NARROW [] synonym: "positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell development involved in immune response" RELATED [GOC:add] synonym: "positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation during immune response" RELATED [GOC:tb] synonym: "positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T lymphocyte differentiation during immune response" RELATED [] synonym: "positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T-cell differentiation during immune response" RELATED [] synonym: "positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T-lymphocyte differentiation during immune response" RELATED [] synonym: "stimulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation during immune response" NARROW [] synonym: "up regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation during immune response" RELATED [] synonym: "up-regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation during immune response" RELATED [] synonym: "upregulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation during immune response" RELATED [] is_a: GO:0002699 ! positive regulation of immune effector process is_a: GO:0032831 ! positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation is_a: GO:0032832 ! regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response is_a: GO:0050778 ! positive regulation of immune response intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0002298 ! positively regulates CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response relationship: RO:0002213 GO:0002298 ! positively regulates CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response [Term] id: GO:0032835 name: glomerulus development namespace: biological_process def: "The progression of the glomerulus over time from its initial formation until its mature state. The glomerulus is a capillary tuft which forms a close network with the visceral epithelium (podocytes) and the mesangium to form the filtration barrier and is surrounded by Bowman's capsule in nephrons of the vertebrate kidney. The glomerulus is part of the nephron and is restricted to one body segment." [GOC:mah, GOC:mtg_kidney_jan10] synonym: "glomerular development" EXACT [] is_a: GO:0048856 ! anatomical structure development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0000074 ! results in development of renal glomerulus relationship: BFO:0000050 GO:0072006 ! part of nephron development relationship: RO:0002296 UBERON:0000074 ! results in development of renal glomerulus [Term] id: GO:0032836 name: glomerular basement membrane development namespace: biological_process def: "The process whose specific outcome is the progression of the glomerular basement membrane over time, from its formation to the mature structure. The glomerular basement membrane is the basal laminal portion of the glomerulus which performs the actual filtration." [GOC:sr] is_a: GO:0030198 ! extracellular matrix organization is_a: GO:0048856 ! anatomical structure development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0005777 ! results in development of glomerular basement membrane relationship: BFO:0000050 GO:0032835 ! part of glomerulus development relationship: RO:0002296 UBERON:0005777 ! results in development of glomerular basement membrane [Term] id: GO:0032838 name: plasma membrane bounded cell projection cytoplasm namespace: cellular_component def: "All of the contents of a plasma membrane bounded cell projection, excluding the plasma membrane surrounding the projection." [GOC:krc, GOC:mah] is_a: GO:0099568 ! cytoplasmic region intersection_of: GO:0005737 ! cytoplasm intersection_of: BFO:0000050 GO:0120025 ! part of plasma membrane bounded cell projection relationship: BFO:0000050 GO:0120025 ! part of plasma membrane bounded cell projection [Term] id: GO:0032839 name: dendrite cytoplasm namespace: cellular_component def: "All of the contents of a dendrite, excluding the surrounding plasma membrane." [GOC:mah] synonym: "dendritic cytoplasm" EXACT [] is_a: GO:0120111 ! neuron projection cytoplasm intersection_of: GO:0005737 ! cytoplasm intersection_of: BFO:0000050 GO:0030425 ! part of dendrite relationship: BFO:0000050 GO:0030425 ! part of dendrite property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/14472" xsd:anyURI [Term] id: GO:0032841 name: calcitonin binding namespace: molecular_function def: "Binding to calcitonin, a peptide hormone responsible for reducing serum calcium levels by inhibiting osteoclastic bone reabsorption and promoting renal calcium excretion. It is synthesized and released by the C cells of the thyroid." [GOC:ecd] is_a: GO:0097644 ! calcitonin family binding intersection_of: GO:0005488 ! binding intersection_of: RO:0004009 CHEBI:3306 ! has primary input relationship: RO:0004009 CHEBI:3306 ! has primary input [Term] id: GO:0032868 name: response to insulin namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insulin stimulus. Insulin is a polypeptide hormone produced by the islets of Langerhans of the pancreas in mammals, and by the homologous organs of other organisms." [GOC:mah, ISBN:0198506732] synonym: "response to insulin stimulus" EXACT [GOC:dos] is_a: GO:0043434 ! response to peptide hormone intersection_of: GO:0042221 ! response to chemical intersection_of: RO:0004009 PR:000009054 ! has primary input preproinsulin relationship: RO:0004009 PR:000009054 ! has primary input preproinsulin property_value: RO:0002161 NCBITaxon:4751 [Term] id: GO:0032869 name: cellular response to insulin stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insulin stimulus. Insulin is a polypeptide hormone produced by the islets of Langerhans of the pancreas in mammals, and by the homologous organs of other organisms." [GOC:mah, ISBN:0198506732] is_a: GO:0032868 ! response to insulin is_a: GO:0071375 ! cellular response to peptide hormone stimulus intersection_of: GO:0070887 ! cellular response to chemical stimulus intersection_of: RO:0004009 PR:000009054 ! has primary input preproinsulin property_value: RO:0002161 NCBITaxon:4751 [Term] id: GO:0032870 name: cellular response to hormone stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hormone stimulus." [GOC:mah] is_a: GO:0009725 ! response to hormone is_a: GO:0070887 ! cellular response to chemical stimulus is_a: GO:0071495 ! cellular response to endogenous stimulus property_value: RO:0002161 NCBITaxon:4751 [Term] id: GO:0032871 name: regulation of karyogamy namespace: biological_process def: "Any process that modulates the frequency, rate or extent of karyogamy, the creation of a single nucleus from multiple nuclei as a result of membrane fusion." [GOC:mah] is_a: GO:1903353 ! regulation of nucleus organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0000741 ! regulates karyogamy relationship: RO:0002211 GO:0000741 ! regulates karyogamy [Term] id: GO:0032878 name: regulation of establishment or maintenance of cell polarity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the specification, formation or maintenance of anisotropic intracellular organization or cell growth patterns." [GOC:mah] is_a: GO:0050794 ! regulation of cellular process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0007163 ! regulates establishment or maintenance of cell polarity relationship: RO:0002211 GO:0007163 ! regulates establishment or maintenance of cell polarity [Term] id: GO:0032879 name: regulation of localization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of any process in which a cell, a substance, or a cellular entity is transported to, or maintained in, a specific location." [GOC:mah] subset: gocheck_do_not_annotate synonym: "regulation of localisation" EXACT [GOC:mah] is_a: GO:0050789 ! regulation of biological process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0051179 ! regulates localization relationship: RO:0002211 GO:0051179 ! regulates localization property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/26424" xsd:anyURI [Term] id: GO:0032880 name: regulation of protein localization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of any process in which a protein is transported to, or maintained in, a specific location." [GOC:dph, GOC:mah, GOC:tb] subset: goslim_chembl synonym: "regulation of cellular protein localisation" EXACT [GOC:TermGenie] synonym: "regulation of cellular protein localization" EXACT [] synonym: "regulation of protein localisation" EXACT [GOC:mah] is_a: GO:0032879 ! regulation of localization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0008104 ! regulates intracellular protein localization relationship: RO:0002211 GO:0008104 ! regulates intracellular protein localization property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/22021" xsd:anyURI creation_date: 2015-01-20T14:32:14Z [Term] id: GO:0032881 name: regulation of polysaccharide metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving polysaccharides." [GOC:mah] is_a: GO:0006109 ! regulation of carbohydrate metabolic process is_a: GO:0060255 ! regulation of macromolecule metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0005976 ! regulates polysaccharide metabolic process relationship: RO:0002211 GO:0005976 ! regulates polysaccharide metabolic process [Term] id: GO:0032885 name: regulation of polysaccharide biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of polysaccharides." [GOC:mah] is_a: GO:0010556 ! regulation of macromolecule biosynthetic process is_a: GO:0032881 ! regulation of polysaccharide metabolic process is_a: GO:0043255 ! regulation of carbohydrate biosynthetic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0000271 ! regulates polysaccharide biosynthetic process relationship: RO:0002211 GO:0000271 ! regulates polysaccharide biosynthetic process [Term] id: GO:0032886 name: regulation of microtubule-based process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of any cellular process that depends upon or alters the microtubule cytoskeleton." [GOC:mah] is_a: GO:0050794 ! regulation of cellular process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0007017 ! regulates microtubule-based process relationship: RO:0002211 GO:0007017 ! regulates microtubule-based process [Term] id: GO:0032890 name: regulation of organic acid transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the directed movement of organic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah] is_a: GO:0051049 ! regulation of transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0015849 ! regulates organic acid transport relationship: RO:0002211 GO:0015849 ! regulates organic acid transport [Term] id: GO:0032891 name: negative regulation of organic acid transport namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of organic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah] synonym: "down regulation of organic acid transport" EXACT [] synonym: "down-regulation of organic acid transport" EXACT [] synonym: "downregulation of organic acid transport" EXACT [] synonym: "inhibition of organic acid transport" NARROW [] is_a: GO:0032890 ! regulation of organic acid transport is_a: GO:0051051 ! negative regulation of transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0015849 ! negatively regulates organic acid transport relationship: RO:0002212 GO:0015849 ! negatively regulates organic acid transport [Term] id: GO:0032892 name: positive regulation of organic acid transport namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the directed movement of organic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah] synonym: "activation of organic acid transport" NARROW [] synonym: "stimulation of organic acid transport" NARROW [] synonym: "up regulation of organic acid transport" EXACT [] synonym: "up-regulation of organic acid transport" EXACT [] synonym: "upregulation of organic acid transport" EXACT [] is_a: GO:0032890 ! regulation of organic acid transport is_a: GO:0051050 ! positive regulation of transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0015849 ! positively regulates organic acid transport relationship: RO:0002213 GO:0015849 ! positively regulates organic acid transport [Term] id: GO:0032928 name: regulation of superoxide anion generation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of enzymatic generation of superoxide by a cell." [GOC:mah] synonym: "regulation of superoxide release" EXACT [GOC:dph, GOC:tb] is_a: GO:0090322 ! regulation of superoxide metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0042554 ! regulates superoxide anion generation relationship: RO:0002211 GO:0042554 ! regulates superoxide anion generation [Term] id: GO:0032929 name: negative regulation of superoxide anion generation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of enzymatic generation of superoxide by a cell." [GOC:mah] synonym: "down regulation of superoxide release" EXACT [] synonym: "down-regulation of superoxide release" EXACT [] synonym: "downregulation of superoxide release" EXACT [] synonym: "inhibition of superoxide release" NARROW [] synonym: "negative regulation of superoxide release" EXACT [GOC:dph, GOC:tb] is_a: GO:0032928 ! regulation of superoxide anion generation is_a: GO:2000378 ! negative regulation of reactive oxygen species metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0042554 ! negatively regulates superoxide anion generation relationship: RO:0002212 GO:0042554 ! negatively regulates superoxide anion generation [Term] id: GO:0032930 name: positive regulation of superoxide anion generation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of enzymatic generation of superoxide by a cell." [GOC:mah] synonym: "activation of superoxide release" NARROW [] synonym: "positive regulation of superoxide release" EXACT [GOC:dph, GOC:tb] synonym: "stimulation of superoxide release" NARROW [] synonym: "up regulation of superoxide release" EXACT [] synonym: "up-regulation of superoxide release" EXACT [] synonym: "upregulation of superoxide release" EXACT [] is_a: GO:0032928 ! regulation of superoxide anion generation is_a: GO:2000379 ! positive regulation of reactive oxygen species metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0042554 ! positively regulates superoxide anion generation relationship: RO:0002213 GO:0042554 ! positively regulates superoxide anion generation [Term] id: GO:0032938 name: negative regulation of translation in response to oxidative stress namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of translation as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals." [GOC:mah] is_a: GO:0032057 ! negative regulation of translational initiation in response to stress is_a: GO:0043556 ! regulation of translation in response to oxidative stress is_a: GO:0043558 ! regulation of translational initiation in response to stress intersection_of: GO:0065007 ! biological regulation intersection_of: BFO:0000050 GO:0034599 ! part of cellular response to oxidative stress intersection_of: RO:0002212 GO:0006413 ! negatively regulates translational initiation [Term] id: GO:0032939 name: positive regulation of translation in response to oxidative stress namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of translation as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals." [GOC:mah] synonym: "activation of translation in response to oxidative stress" NARROW [] synonym: "stimulation of translation in response to oxidative stress" NARROW [] synonym: "up regulation of translation in response to oxidative stress" EXACT [] synonym: "up-regulation of translation in response to oxidative stress" EXACT [] synonym: "upregulation of translation in response to oxidative stress" EXACT [] is_a: GO:0032056 ! positive regulation of translation in response to stress intersection_of: GO:0065007 ! biological regulation intersection_of: BFO:0000050 GO:0034599 ! part of cellular response to oxidative stress intersection_of: RO:0002213 GO:0006412 ! positively regulates translation relationship: BFO:0000050 GO:0034599 ! part of cellular response to oxidative stress [Term] id: GO:0032940 name: secretion by cell namespace: biological_process def: "The controlled release of a substance by a cell." [GOC:mah] synonym: "cellular secretion" EXACT [] xref: Wikipedia:Secretion is_a: GO:0046903 ! secretion is_a: GO:0140352 ! export from cell [Term] id: GO:0032941 name: secretion by tissue namespace: biological_process def: "The controlled release of a substance by a tissue." [GOC:mah] synonym: "expulsion of gland contents" RELATED [GOC:mah] synonym: "tissue secretion" EXACT [] is_a: GO:0032501 ! multicellular organismal process is_a: GO:0046903 ! secretion property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0032943 name: mononuclear cell proliferation namespace: biological_process def: "The expansion of a mononuclear cell population by cell division. A mononuclear cell is a leukocyte with a single non-segmented nucleus in the mature form." [GOC:add] synonym: "PBMC proliferation" NARROW [] synonym: "peripheral blood mononuclear cell proliferation" NARROW [] is_a: GO:0070661 ! leukocyte proliferation intersection_of: GO:0008283 ! cell population proliferation intersection_of: RO:0012003 CL:0000842 ! acts on population of mononuclear leukocyte relationship: RO:0012003 CL:0000842 ! acts on population of mononuclear leukocyte [Term] id: GO:0032944 name: regulation of mononuclear cell proliferation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of mononuclear cell proliferation." [GOC:add] synonym: "regulation of PBMC proliferation" NARROW [] synonym: "regulation of peripheral blood mononuclear cell proliferation" NARROW [] is_a: GO:0070663 ! regulation of leukocyte proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0032943 ! regulates mononuclear cell proliferation relationship: RO:0002211 GO:0032943 ! regulates mononuclear cell proliferation [Term] id: GO:0032945 name: negative regulation of mononuclear cell proliferation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of mononuclear cell proliferation." [GOC:add] synonym: "negative regulation of PBMC proliferation" NARROW [] synonym: "negative regulation of peripheral blood mononuclear cell proliferation" NARROW [] is_a: GO:0032944 ! regulation of mononuclear cell proliferation is_a: GO:0070664 ! negative regulation of leukocyte proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0032943 ! negatively regulates mononuclear cell proliferation relationship: RO:0002212 GO:0032943 ! negatively regulates mononuclear cell proliferation [Term] id: GO:0032946 name: positive regulation of mononuclear cell proliferation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of mononuclear cell proliferation." [GOC:add] synonym: "activation of mononuclear cell proliferation" NARROW [] synonym: "positive regulation of PBMC proliferation" NARROW [] synonym: "positive regulation of peripheral blood mononuclear cell proliferation" NARROW [] synonym: "stimulation of mononuclear cell proliferation" NARROW [] synonym: "up regulation of mononuclear cell proliferation" EXACT [] synonym: "up-regulation of mononuclear cell proliferation" EXACT [] synonym: "upregulation of mononuclear cell proliferation" EXACT [] is_a: GO:0032944 ! regulation of mononuclear cell proliferation is_a: GO:0070665 ! positive regulation of leukocyte proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0032943 ! positively regulates mononuclear cell proliferation relationship: RO:0002213 GO:0032943 ! positively regulates mononuclear cell proliferation [Term] id: GO:0032956 name: regulation of actin cytoskeleton organization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins." [GOC:mah] synonym: "regulation of actin cytoskeleton organisation" EXACT [GOC:mah] synonym: "regulation of actin cytoskeleton organization and biogenesis" RELATED [GOC:mah] is_a: GO:0032970 ! regulation of actin filament-based process is_a: GO:0051493 ! regulation of cytoskeleton organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0030036 ! regulates actin cytoskeleton organization relationship: RO:0002211 GO:0030036 ! regulates actin cytoskeleton organization [Term] id: GO:0032963 name: collagen metabolic process namespace: biological_process def: "The chemical reactions and pathways involving collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals. Collagen is highly enriched in glycine (some regions are 33% glycine) and proline, occurring predominantly as 3-hydroxyproline (about 20%)." [GOC:mah, ISBN:0198506732] synonym: "collagen metabolism" EXACT [] is_a: BFO:0000003 is_a: GO:0008152 ! metabolic process intersection_of: GO:0008152 ! metabolic process intersection_of: RO:0004007 GO:0005581 ! has primary input or output collagen trimer relationship: RO:0004007 GO:0005581 ! has primary input or output collagen trimer [Term] id: GO:0032964 name: collagen biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals. Collagen is highly enriched in glycine (some regions are 33% glycine) and proline, occurring predominantly as 3-hydroxyproline (about 20%)." [GOC:mah, ISBN:0198506732] synonym: "collagen anabolism" EXACT [] synonym: "collagen biosynthesis" EXACT [] synonym: "collagen formation" EXACT [] synonym: "collagen synthesis" EXACT [] is_a: GO:0009058 ! biosynthetic process is_a: GO:0032963 ! collagen metabolic process intersection_of: GO:0009058 ! biosynthetic process intersection_of: RO:0004008 GO:0005581 ! has primary output collagen trimer relationship: RO:0004008 GO:0005581 ! has primary output collagen trimer [Term] id: GO:0032965 name: regulation of collagen biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals." [GOC:mah] synonym: "regulation of collagen anabolism" EXACT [] synonym: "regulation of collagen biosynthesis" EXACT [] synonym: "regulation of collagen formation" EXACT [] synonym: "regulation of collagen synthesis" EXACT [] is_a: GO:0009889 ! regulation of biosynthetic process is_a: GO:0010712 ! regulation of collagen metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0032964 ! regulates collagen biosynthetic process relationship: RO:0002211 GO:0032964 ! regulates collagen biosynthetic process [Term] id: GO:0032966 name: negative regulation of collagen biosynthetic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals." [GOC:mah] synonym: "negative regulation of collagen anabolism" EXACT [] synonym: "negative regulation of collagen biosynthesis" EXACT [] synonym: "negative regulation of collagen formation" EXACT [] synonym: "negative regulation of collagen synthesis" EXACT [] is_a: GO:0009890 ! negative regulation of biosynthetic process is_a: GO:0010713 ! negative regulation of collagen metabolic process is_a: GO:0032965 ! regulation of collagen biosynthetic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0032964 ! negatively regulates collagen biosynthetic process relationship: RO:0002212 GO:0032964 ! negatively regulates collagen biosynthetic process [Term] id: GO:0032967 name: positive regulation of collagen biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals." [GOC:mah] synonym: "positive regulation of collagen anabolism" EXACT [] synonym: "positive regulation of collagen biosynthesis" EXACT [] synonym: "positive regulation of collagen formation" EXACT [] synonym: "positive regulation of collagen synthesis" EXACT [] is_a: GO:0009891 ! positive regulation of biosynthetic process is_a: GO:0010714 ! positive regulation of collagen metabolic process is_a: GO:0032965 ! regulation of collagen biosynthetic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0032964 ! positively regulates collagen biosynthetic process relationship: RO:0002213 GO:0032964 ! positively regulates collagen biosynthetic process [Term] id: GO:0032970 name: regulation of actin filament-based process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of any cellular process that depends upon or alters the actin cytoskeleton." [GOC:mah] is_a: GO:0050794 ! regulation of cellular process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0030029 ! regulates actin filament-based process relationship: RO:0002211 GO:0030029 ! regulates actin filament-based process [Term] id: GO:0032973 name: amino acid export across plasma membrane namespace: biological_process def: "The directed movement of amino acids from inside of a cell, across the plasma membrane and into the extracellular region." [GOC:jl] synonym: "amino acid efflux" EXACT [] synonym: "amino acid export" BROAD [] synonym: "amino acid transmembrane export" BROAD [] is_a: GO:0003333 ! amino acid transmembrane transport is_a: GO:0140115 ! export across plasma membrane intersection_of: GO:0006810 ! transport intersection_of: RO:0002338 GO:0005829 ! has target start location cytosol intersection_of: RO:0002339 GO:0005576 ! has target end location extracellular region intersection_of: RO:0002342 GO:0005886 ! results in transport across plasma membrane intersection_of: RO:0004009 CHEBI:35238 ! has primary input creation_date: 2012-11-14T14:27:40Z [Term] id: GO:0032974 name: amino acid transmembrane export from vacuole namespace: biological_process def: "The directed movement of amino acids out of the vacuole, across the vacuolar membrane." [GOC:mah] synonym: "amino acid efflux from vacuole" EXACT [] synonym: "vacuolar amino acid export" EXACT [] is_a: GO:0003333 ! amino acid transmembrane transport is_a: GO:0034486 ! vacuolar transmembrane transport intersection_of: GO:0055085 ! transmembrane transport intersection_of: RO:0002338 GO:0005775 ! has target start location vacuolar lumen intersection_of: RO:0002339 GO:0005829 ! has target end location cytosol intersection_of: RO:0004009 CHEBI:35238 ! has primary input relationship: RO:0002338 GO:0005775 ! has target start location vacuolar lumen relationship: RO:0002339 GO:0005829 ! has target end location cytosol [Term] id: GO:0032975 name: amino acid transmembrane import into vacuole namespace: biological_process def: "The directed movement of amino acids into the vacuole across the vacuolar membrane." [GOC:mah] synonym: "vacuolar amino acid import" EXACT [] is_a: GO:0003333 ! amino acid transmembrane transport is_a: GO:0034486 ! vacuolar transmembrane transport intersection_of: GO:0055085 ! transmembrane transport intersection_of: RO:0002338 GO:0005829 ! has target start location cytosol intersection_of: RO:0002339 GO:0005775 ! has target end location vacuolar lumen intersection_of: RO:0004009 CHEBI:35238 ! has primary input relationship: RO:0002338 GO:0005829 ! has target start location cytosol relationship: RO:0002339 GO:0005775 ! has target end location vacuolar lumen [Term] id: GO:0032980 name: keratinocyte activation namespace: biological_process def: "A change in the morphology or behavior of a keratinocyte resulting from exposure to an activating factor such as a cellular or soluble ligand. Upon activation, keratinocytes become migratory and hyperproliferative, and produce growth factors and cytokines." [GOC:mah, PMID:15737202] is_a: BFO:0000003 is_a: GO:0001775 ! cell activation intersection_of: GO:0001775 ! cell activation intersection_of: RO:0004009 CL:0000312 ! has primary input keratinocyte relationship: RO:0004009 CL:0000312 ! has primary input keratinocyte property_value: RO:0002161 NCBITaxon:6656 [Term] id: GO:0032983 name: kainate selective glutamate receptor complex namespace: cellular_component def: "An assembly of four or five subunits which form a structure with an extracellular N-terminus and a large loop that together form the ligand binding domain. The C-terminus is intracellular. The ionotropic glutamate receptor complex itself acts as a ligand gated ion channel; on binding glutamate, charged ions pass through a channel in the center of the receptor complex. Kainate receptors are multimeric assemblies of GluK1-3 (also called GluR5-7), GluK4 (KA1) and GluK5 (KA2) subunits." [GOC:bf, PMID:18655795] is_a: GO:0008328 ! ionotropic glutamate receptor complex is_a: GO:0034705 ! potassium channel complex is_a: GO:0034706 ! sodium channel complex intersection_of: GO:0032991 ! protein-containing complex intersection_of: RO:0002215 GO:0015277 ! capable of kainate selective glutamate receptor activity relationship: RO:0002215 GO:0015277 ! capable of kainate selective glutamate receptor activity [Term] id: GO:0032984 name: protein-containing complex disassembly namespace: biological_process def: "The disaggregation of a protein-containing macromolecular complex into its constituent components." [GOC:mah] synonym: "cellular macromolecule complex disassembly" RELATED [] synonym: "cellular protein complex disassembly" RELATED [] synonym: "macromolecule complex disassembly" RELATED [] synonym: "protein complex disassembly" EXACT [] is_a: GO:0022411 ! cellular component disassembly is_a: GO:0043933 ! protein-containing complex organization intersection_of: GO:0022411 ! cellular component disassembly intersection_of: RO:0002590 GO:0032991 ! results in disassembly of protein-containing complex relationship: RO:0002590 GO:0032991 ! results in disassembly of protein-containing complex property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/22580" xsd:anyURI [Term] id: GO:0032987 name: protein-lipid complex disassembly namespace: biological_process def: "The disaggregation of a protein-lipid complex into its constituent components." [GOC:mah] is_a: GO:0032984 ! protein-containing complex disassembly is_a: GO:0071825 ! protein-lipid complex organization intersection_of: GO:0022411 ! cellular component disassembly intersection_of: RO:0002590 GO:0032994 ! results in disassembly of protein-lipid complex relationship: RO:0002590 GO:0032994 ! results in disassembly of protein-lipid complex [Term] id: GO:0032988 name: protein-RNA complex disassembly namespace: biological_process def: "The disaggregation of a protein-RNA complex into its constituent components." [GOC:mah] synonym: "ribonucleoprotein complex disassembly" EXACT [] synonym: "RNA-protein complex disassembly" EXACT [] synonym: "RNP complex disassembly" EXACT [] is_a: GO:0032984 ! protein-containing complex disassembly is_a: GO:0071826 ! protein-RNA complex organization intersection_of: GO:0022411 ! cellular component disassembly intersection_of: RO:0002590 GO:1990904 ! results in disassembly of ribonucleoprotein complex relationship: RO:0002590 GO:1990904 ! results in disassembly of ribonucleoprotein complex property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/25143" xsd:anyURI [Term] id: GO:0032989 name: cellular anatomical entity morphogenesis namespace: biological_process def: "The process in which a cellular entity is generated and organized. A cellular entity has granularity above the level of a protein complex but below that of an anatomical system." [GOC:dph, GOC:mah, GOC:tb] subset: goslim_pir synonym: "cellular component morphogenesis" EXACT [] synonym: "cellular structure morphogenesis" EXACT [GOC:dph, GOC:tb] is_a: GO:0016043 ! cellular component organization property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/25496" xsd:anyURI property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/26249" xsd:anyURI [Term] id: GO:0032991 name: protein-containing complex namespace: cellular_component def: "A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together." [GOC:dos, GOC:mah] comment: A protein complex in this context is meant as a stable set of interacting proteins which can be co-purified by an acceptable method, and where the complex has been shown to exist as an isolated, functional unit in vivo. Acceptable experimental methods include stringent protein purification followed by detection of protein interaction. The following methods should be considered non-acceptable: simple immunoprecipitation, pull-down experiments from cell extracts without further purification, colocalization and 2-hybrid screening. Interactions that should not be captured as protein complexes include: 1) enzyme/substrate, receptor/ligand or any similar transient interactions, unless these are a critical part of the complex assembly or are required e.g. for the receptor to be functional; 2) proteins associated in a pull-down/co-immunoprecipitation assay with no functional link or any evidence that this is a defined biological entity rather than a loose-affinity complex; 3) any complex where the only evidence is based on genetic interaction data; 4) partial complexes, where some subunits (e.g. transmembrane ones) cannot be expressed as recombinant proteins and are excluded from experiments (in this case, independent evidence is necessary to find out the composition of the full complex, if known). Interactions that may be captured as protein complexes include: 1) enzyme/substrate or receptor/ligand if the complex can only assemble and become functional in the presence of both classes of subunits; 2) complexes where one of the members has not been shown to be physically linked to the other(s), but is a homologue of, and has the same functionality as, a protein that has been experimentally demonstrated to form a complex with the other member(s); 3) complexes whose existence is accepted based on localization and pharmacological studies, but for which experimental evidence is not yet available for the complex as a whole. subset: goslim_agr subset: goslim_chembl subset: goslim_euk_cellular_processes_ribbon subset: goslim_flybase_ribbon subset: goslim_mouse subset: goslim_pir synonym: "macromolecular complex" EXACT [] synonym: "macromolecule complex" EXACT [] synonym: "protein complex" NARROW [] synonym: "protein containing complex" EXACT [] synonym: "protein-protein complex" NARROW [] is_a: GO:0005575 ! cellular_component disjoint_from: GO:0044423 ! virion component disjoint_from: GO:0110165 ! cellular anatomical structure relationship: BFO:0000051 PR:000000001 ! has part protein [Term] id: GO:0032994 name: protein-lipid complex namespace: cellular_component def: "A macromolecular complex containing separate protein and lipid molecules. Separate in this context means not covalently bound to each other." [GOC:mah] comment: Macromolecular complexes in which the lipid component is all covalently bound to protein are not considered protein-lipid complexes. is_a: GO:0032991 ! protein-containing complex relationship: BFO:0000051 CHEBI:18059 ! has part [Term] id: GO:0032997 name: Fc receptor complex namespace: cellular_component def: "A protein complex composed of a subunit or subunits capable of binding the Fc portion of an immunoglobulin with additional signaling components. The complex functions as a receptor for immunoglobulin." [GOC:add, ISBN:0781735149] subset: goslim_pir synonym: "Fc-receptor complex" EXACT [] synonym: "FcR complex" EXACT [] synonym: "immunoglobulin receptor complex" BROAD [] is_a: GO:0098797 ! plasma membrane protein complex [Term] id: GO:0033001 name: Fc-gamma receptor III complex namespace: cellular_component def: "A protein complex composed of an Fc-gamma RIII alpha chain and an Fc-epsilon RI gamma chain dimer with or without an Fc-epsilon RI beta chain and additional signaling components. The complex functions primarily as an activating receptor for IgG." [GOC:add, ISBN:0781735149, PMID:11244038, PMID:12413532] synonym: "FcgRIII complex" EXACT [] synonym: "IgG receptor complex" BROAD [] synonym: "immunoglobulin G receptor complex" BROAD [] is_a: GO:0032997 ! Fc receptor complex [Term] id: GO:0033002 name: muscle cell proliferation namespace: biological_process def: "The expansion of a muscle cell population by cell division." [CL:0000187, GOC:mah] synonym: "myocyte proliferation" EXACT [] is_a: BFO:0000003 is_a: GO:0008283 ! cell population proliferation intersection_of: GO:0008283 ! cell population proliferation intersection_of: RO:0012003 CL:0000187 ! acts on population of muscle cell relationship: RO:0012003 CL:0000187 ! acts on population of muscle cell property_value: RO:0002161 NCBITaxon:4751 [Term] id: GO:0033003 name: regulation of mast cell activation namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of mast cell activation." [GOC:mah] is_a: GO:0002694 ! regulation of leukocyte activation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0045576 ! regulates mast cell activation relationship: RO:0002211 GO:0045576 ! regulates mast cell activation [Term] id: GO:0033004 name: negative regulation of mast cell activation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of mast cell activation." [GOC:mah] is_a: GO:0002695 ! negative regulation of leukocyte activation is_a: GO:0033003 ! regulation of mast cell activation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0045576 ! negatively regulates mast cell activation relationship: RO:0002212 GO:0045576 ! negatively regulates mast cell activation [Term] id: GO:0033005 name: positive regulation of mast cell activation namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of mast cell activation." [GOC:mah] is_a: GO:0002696 ! positive regulation of leukocyte activation is_a: GO:0033003 ! regulation of mast cell activation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0045576 ! positively regulates mast cell activation relationship: RO:0002213 GO:0045576 ! positively regulates mast cell activation [Term] id: GO:0033006 name: regulation of mast cell activation involved in immune response namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of mast cell activation as part of an immune response." [GOC:mah] synonym: "regulation of mast cell activation during immune response" RELATED [GOC:tb] is_a: GO:0002699 ! positive regulation of immune effector process is_a: GO:0033003 ! regulation of mast cell activation is_a: GO:0050776 ! regulation of immune response intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0002279 ! regulates mast cell activation involved in immune response relationship: RO:0002211 GO:0002279 ! regulates mast cell activation involved in immune response [Term] id: GO:0033007 name: negative regulation of mast cell activation involved in immune response namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of mast cell activation as part of an immune response." [GOC:mah] synonym: "negative regulation of mast cell activation during immune response" RELATED [GOC:tb] is_a: GO:0002698 ! negative regulation of immune effector process is_a: GO:0033004 ! negative regulation of mast cell activation is_a: GO:0033006 ! regulation of mast cell activation involved in immune response is_a: GO:0050777 ! negative regulation of immune response intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0002279 ! negatively regulates mast cell activation involved in immune response relationship: RO:0002212 GO:0002279 ! negatively regulates mast cell activation involved in immune response [Term] id: GO:0033008 name: positive regulation of mast cell activation involved in immune response namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of mast cell activation as part of an immune response." [GOC:mah] synonym: "positive regulation of mast cell activation during immune response" RELATED [GOC:tb] is_a: GO:0033005 ! positive regulation of mast cell activation is_a: GO:0033006 ! regulation of mast cell activation involved in immune response is_a: GO:0050778 ! positive regulation of immune response intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0002279 ! positively regulates mast cell activation involved in immune response relationship: RO:0002213 GO:0002279 ! positively regulates mast cell activation involved in immune response [Term] id: GO:0033023 name: mast cell homeostasis namespace: biological_process def: "The process of regulating the proliferation and elimination of mast cells such that the total number of mast cells within a whole or part of an organism is stable over time in the absence of an outside stimulus." [GOC:add, PMID:11292031] comment: Note that this term represents the return of mast cell levels to stable numbers following an immune response as well as the proliferation and elimination of mast cells required to maintain stable numbers in the absence of an outside stimulus. is_a: GO:0001776 ! leukocyte homeostasis is_a: GO:0002262 ! myeloid cell homeostasis intersection_of: GO:0048872 ! homeostasis of number of cells intersection_of: RO:0012003 CL:0000097 ! acts on population of mast cell relationship: RO:0012003 CL:0000097 ! acts on population of mast cell [Term] id: GO:0033024 name: mast cell apoptotic process namespace: biological_process def: "Any apoptotic process in a mast cell, a cell that is found in almost all tissues containing numerous basophilic granules and capable of releasing large amounts of histamine and heparin upon activation." [CL:0000097, GOC:add, GOC:mtg_apoptosis, PMID:11292031, PMID:12360215, PMID:16605130] synonym: "apoptosis of mast cells" EXACT [] synonym: "mast cell apoptosis" NARROW [] is_a: GO:0033028 ! myeloid cell apoptotic process is_a: GO:0071887 ! leukocyte apoptotic process intersection_of: GO:0006915 ! apoptotic process intersection_of: BFO:0000066 CL:0000097 ! occurs in mast cell relationship: BFO:0000050 GO:0033023 ! part of mast cell homeostasis relationship: BFO:0000066 CL:0000097 ! occurs in mast cell [Term] id: GO:0033025 name: regulation of mast cell apoptotic process namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of mast cell apoptotic process." [GOC:add, GOC:mtg_apoptosis] synonym: "regulation of mast cell apoptosis" NARROW [] is_a: GO:0002682 ! regulation of immune system process is_a: GO:0033032 ! regulation of myeloid cell apoptotic process is_a: GO:2000106 ! regulation of leukocyte apoptotic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0033024 ! regulates mast cell apoptotic process relationship: RO:0002211 GO:0033024 ! regulates mast cell apoptotic process [Term] id: GO:0033026 name: negative regulation of mast cell apoptotic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of mast cell apoptotic process." [GOC:add, GOC:mtg_apoptosis] synonym: "down regulation of mast cell apoptosis" EXACT [] synonym: "down-regulation of mast cell apoptosis" EXACT [] synonym: "downregulation of mast cell apoptosis" EXACT [] synonym: "inhibition of mast cell apoptosis" NARROW [] synonym: "negative regulation of mast cell apoptosis" NARROW [] is_a: GO:0002683 ! negative regulation of immune system process is_a: GO:0033025 ! regulation of mast cell apoptotic process is_a: GO:0033033 ! negative regulation of myeloid cell apoptotic process is_a: GO:2000107 ! negative regulation of leukocyte apoptotic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0033024 ! negatively regulates mast cell apoptotic process relationship: RO:0002212 GO:0033024 ! negatively regulates mast cell apoptotic process [Term] id: GO:0033027 name: positive regulation of mast cell apoptotic process namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of mast cell apoptotic process." [GOC:add, GOC:mtg_apoptosis] synonym: "activation of mast cell apoptosis" NARROW [] synonym: "positive regulation of mast cell apoptosis" NARROW [] synonym: "stimulation of mast cell apoptosis" NARROW [] synonym: "up regulation of mast cell apoptosis" EXACT [] synonym: "up-regulation of mast cell apoptosis" EXACT [] synonym: "upregulation of mast cell apoptosis" EXACT [] is_a: GO:0002684 ! positive regulation of immune system process is_a: GO:0033025 ! regulation of mast cell apoptotic process is_a: GO:0033034 ! positive regulation of myeloid cell apoptotic process is_a: GO:2000108 ! positive regulation of leukocyte apoptotic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0033024 ! positively regulates mast cell apoptotic process relationship: RO:0002213 GO:0033024 ! positively regulates mast cell apoptotic process [Term] id: GO:0033028 name: myeloid cell apoptotic process namespace: biological_process def: "Any apoptotic process in a myeloid cell, a cell of the monocyte, granulocyte, mast cell, megakaryocyte, or erythroid lineage." [CL:0000763, GOC:add, GOC:mtg_apoptosis, PMID:11292031, PMID:15330259, PMID:17133093] synonym: "apoptosis of myeloid cells" EXACT [] synonym: "myeloid cell apoptosis" NARROW [] is_a: GO:0006915 ! apoptotic process intersection_of: GO:0006915 ! apoptotic process intersection_of: BFO:0000066 CL:0000763 ! occurs in myeloid cell relationship: BFO:0000066 CL:0000763 ! occurs in myeloid cell property_value: RO:0002161 NCBITaxon:4896 [Term] id: GO:0033029 name: regulation of neutrophil apoptotic process namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of neutrophil apoptotic process." [GOC:add, GOC:mtg_apoptosis] synonym: "regulation of neutrophil apoptosis" NARROW [] is_a: GO:0002682 ! regulation of immune system process is_a: GO:0033032 ! regulation of myeloid cell apoptotic process is_a: GO:2000106 ! regulation of leukocyte apoptotic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0001781 ! regulates neutrophil apoptotic process relationship: RO:0002211 GO:0001781 ! regulates neutrophil apoptotic process [Term] id: GO:0033030 name: negative regulation of neutrophil apoptotic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of neutrophil apoptotic process." [GOC:add, GOC:mtg_apoptosis] synonym: "down regulation of neutrophil apoptosis" EXACT [] synonym: "down-regulation of neutrophil apoptosis" EXACT [] synonym: "downregulation of neutrophil apoptosis" EXACT [] synonym: "inhibition of neutrophil apoptosis" NARROW [] synonym: "negative regulation of neutrophil apoptosis" NARROW [] is_a: GO:0033029 ! regulation of neutrophil apoptotic process is_a: GO:0033033 ! negative regulation of myeloid cell apoptotic process is_a: GO:2000107 ! negative regulation of leukocyte apoptotic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0001781 ! negatively regulates neutrophil apoptotic process relationship: RO:0002212 GO:0001781 ! negatively regulates neutrophil apoptotic process [Term] id: GO:0033031 name: positive regulation of neutrophil apoptotic process namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of neutrophil apoptotic process." [GOC:add, GOC:mtg_apoptosis] synonym: "activation of neutrophil apoptosis" NARROW [] synonym: "positive regulation of neutrophil apoptosis" NARROW [] synonym: "stimulation of neutrophil apoptosis" NARROW [] synonym: "up regulation of neutrophil apoptosis" EXACT [] synonym: "up-regulation of neutrophil apoptosis" EXACT [] synonym: "upregulation of neutrophil apoptosis" EXACT [] is_a: GO:0002684 ! positive regulation of immune system process is_a: GO:0033029 ! regulation of neutrophil apoptotic process is_a: GO:0033034 ! positive regulation of myeloid cell apoptotic process is_a: GO:2000108 ! positive regulation of leukocyte apoptotic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0001781 ! positively regulates neutrophil apoptotic process relationship: RO:0002213 GO:0001781 ! positively regulates neutrophil apoptotic process [Term] id: GO:0033032 name: regulation of myeloid cell apoptotic process namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of myeloid cell apoptotic process." [GOC:add, GOC:mtg_apoptosis] synonym: "regulation of myeloid cell apoptosis" NARROW [] is_a: GO:0042981 ! regulation of apoptotic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0033028 ! regulates myeloid cell apoptotic process relationship: RO:0002211 GO:0033028 ! regulates myeloid cell apoptotic process property_value: RO:0002161 NCBITaxon:4896 [Term] id: GO:0033033 name: negative regulation of myeloid cell apoptotic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of a myeloid cell apoptotic process." [GOC:add, GOC:mtg_apoptosis] synonym: "down regulation of myeloid cell apoptosis" EXACT [] synonym: "down-regulation of myeloid cell apoptosis" EXACT [] synonym: "downregulation of myeloid cell apoptosis" EXACT [] synonym: "inhibition of myeloid cell apoptosis" NARROW [] synonym: "negative regulation of myeloid cell apoptosis" NARROW [] is_a: GO:0033032 ! regulation of myeloid cell apoptotic process is_a: GO:0043066 ! negative regulation of apoptotic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0033028 ! negatively regulates myeloid cell apoptotic process relationship: RO:0002212 GO:0033028 ! negatively regulates myeloid cell apoptotic process property_value: RO:0002161 NCBITaxon:4896 [Term] id: GO:0033034 name: positive regulation of myeloid cell apoptotic process namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of myeloid cell apoptotic process." [GOC:add, GOC:mtg_apoptosis] synonym: "activation of myeloid cell apoptosis" NARROW [] synonym: "positive regulation of myeloid cell apoptosis" NARROW [] synonym: "stimulation of myeloid cell apoptosis" NARROW [] synonym: "up regulation of myeloid cell apoptosis" EXACT [] synonym: "up-regulation of myeloid cell apoptosis" EXACT [] synonym: "upregulation of myeloid cell apoptosis" EXACT [] is_a: GO:0033032 ! regulation of myeloid cell apoptotic process is_a: GO:0043065 ! positive regulation of apoptotic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0033028 ! positively regulates myeloid cell apoptotic process relationship: RO:0002213 GO:0033028 ! positively regulates myeloid cell apoptotic process property_value: RO:0002161 NCBITaxon:4896 [Term] id: GO:0033036 name: macromolecule localization namespace: biological_process def: "Any process in which a macromolecule is transported to, or maintained in, a specific location." [GOC:mah] subset: gocheck_do_not_annotate subset: goslim_flybase_ribbon synonym: "macromolecule localisation" EXACT [GOC:mah] is_a: GO:0051179 ! localization [Term] id: GO:0033037 name: polysaccharide localization namespace: biological_process def: "Any process in which a polysaccharide is transported to, or maintained in, a specific location." [GOC:mah] synonym: "polysaccharide localisation" EXACT [GOC:mah] is_a: BFO:0000003 is_a: GO:0033036 ! macromolecule localization intersection_of: GO:0033036 ! macromolecule localization intersection_of: RO:0004009 CHEBI:18154 ! has primary input relationship: RO:0004009 CHEBI:18154 ! has primary input [Term] id: GO:0033043 name: regulation of organelle organization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of an organelle." [GOC:mah] subset: gocheck_do_not_annotate subset: goslim_yeast synonym: "regulation of organelle organisation" EXACT [GOC:mah] synonym: "regulation of organelle organization and biogenesis" RELATED [GOC:mah] is_a: GO:0051128 ! regulation of cellular component organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0006996 ! regulates organelle organization relationship: RO:0002211 GO:0006996 ! regulates organelle organization [Term] id: GO:0033044 name: regulation of chromosome organization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a chromosome." [GOC:mah] synonym: "regulation of chromosome organisation" EXACT [GOC:mah] synonym: "regulation of chromosome organization and biogenesis" RELATED [GOC:mah] is_a: GO:0033043 ! regulation of organelle organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0051276 ! regulates chromosome organization relationship: RO:0002211 GO:0051276 ! regulates chromosome organization [Term] id: GO:0033045 name: regulation of sister chromatid segregation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of sister chromatid segregation." [GOC:mah] is_a: GO:0033044 ! regulation of chromosome organization is_a: GO:0051983 ! regulation of chromosome segregation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0000819 ! regulates sister chromatid segregation relationship: RO:0002211 GO:0000819 ! regulates sister chromatid segregation [Term] id: GO:0033046 name: negative regulation of sister chromatid segregation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of sister chromatid segregation." [GOC:mah] is_a: GO:0033045 ! regulation of sister chromatid segregation is_a: GO:0051985 ! negative regulation of chromosome segregation is_a: GO:2001251 ! negative regulation of chromosome organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0000819 ! negatively regulates sister chromatid segregation relationship: RO:0002212 GO:0000819 ! negatively regulates sister chromatid segregation [Term] id: GO:0033047 name: regulation of mitotic sister chromatid segregation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of sister chromatid segregation during mitosis." [GOC:mah] is_a: GO:0033045 ! regulation of sister chromatid segregation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0000070 ! regulates mitotic sister chromatid segregation relationship: RO:0002211 GO:0000070 ! regulates mitotic sister chromatid segregation [Term] id: GO:0033048 name: negative regulation of mitotic sister chromatid segregation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of sister chromatid segregation during mitosis." [GOC:mah] is_a: GO:0033046 ! negative regulation of sister chromatid segregation is_a: GO:0033047 ! regulation of mitotic sister chromatid segregation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0000070 ! negatively regulates mitotic sister chromatid segregation relationship: RO:0002212 GO:0000070 ! negatively regulates mitotic sister chromatid segregation [Term] id: GO:0033059 name: cellular pigmentation namespace: biological_process def: "The deposition or aggregation of coloring matter in a cell." [GOC:mtg_MIT_16mar07] is_a: GO:0009987 ! cellular process is_a: GO:0043473 ! pigmentation [Term] id: GO:0033077 name: T cell differentiation in thymus namespace: biological_process def: "The process in which a precursor cell type acquires the specialized features of a T cell via a differentiation pathway dependent upon transit through the thymus." [GOC:add, ISBN:0781735149] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "T cell development in thymus" RELATED [GOC:add] synonym: "thymic T cell differentiation" EXACT [] synonym: "thymocyte cell differentiation" EXACT [] synonym: "thymocyte differentiation" EXACT [] is_a: GO:0030217 ! T cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000893 ! results in acquisition of features of thymocyte relationship: RO:0002162 NCBITaxon:7776 ! in taxon Gnathostomata relationship: RO:0002315 CL:0000893 ! results in acquisition of features of thymocyte [Term] id: GO:0033079 name: immature T cell proliferation namespace: biological_process def: "The expansion of an immature T cell population by cell division." [GOC:add, ISBN:0781735149] is_a: GO:0042098 ! T cell proliferation intersection_of: GO:0008283 ! cell population proliferation intersection_of: RO:0012003 CL:0002420 ! acts on population of immature T cell relationship: RO:0012003 CL:0002420 ! acts on population of immature T cell [Term] id: GO:0033080 name: immature T cell proliferation in thymus namespace: biological_process def: "The expansion of an immature T cell population by cell division in the thymus." [GOC:add, ISBN:0781735149] synonym: "thymic T cell proliferation" EXACT [] synonym: "thymocyte cell proliferation" EXACT [] synonym: "thymocyte proliferation" EXACT [] is_a: GO:0033079 ! immature T cell proliferation intersection_of: GO:0008283 ! cell population proliferation intersection_of: RO:0012003 CL:0000893 ! acts on population of thymocyte relationship: BFO:0000050 GO:0033077 ! part of T cell differentiation in thymus relationship: RO:0012003 CL:0000893 ! acts on population of thymocyte [Term] id: GO:0033081 name: regulation of T cell differentiation in thymus namespace: biological_process def: "Any process that modulates the frequency, rate or extent of T cell differentiation in the thymus." [GOC:add, GOC:mah] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "regulation of T cell development in thymus" RELATED [GOC:add] synonym: "regulation of thymic T cell differentiation" EXACT [] synonym: "regulation of thymocyte cell differentiation" EXACT [] synonym: "regulation of thymocyte differentiation" EXACT [] is_a: GO:0045580 ! regulation of T cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0033077 ! regulates T cell differentiation in thymus relationship: RO:0002211 GO:0033077 ! regulates T cell differentiation in thymus [Term] id: GO:0033083 name: regulation of immature T cell proliferation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of immature T cell proliferation." [GOC:add, GOC:mah] is_a: GO:0042129 ! regulation of T cell proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0033079 ! regulates immature T cell proliferation relationship: RO:0002211 GO:0033079 ! regulates immature T cell proliferation [Term] id: GO:0033084 name: regulation of immature T cell proliferation in thymus namespace: biological_process def: "Any process that modulates the frequency, rate or extent of immature T cell proliferation in the thymus." [GOC:add, GOC:mah] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "regulation of thymic T cell proliferation" EXACT [] synonym: "regulation of thymocyte cell proliferation" EXACT [] synonym: "regulation of thymocyte proliferation" EXACT [] is_a: GO:0033083 ! regulation of immature T cell proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0033080 ! regulates immature T cell proliferation in thymus relationship: RO:0002211 GO:0033080 ! regulates immature T cell proliferation in thymus [Term] id: GO:0033085 name: negative regulation of T cell differentiation in thymus namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of T cell differentiation in the thymus." [GOC:add, GOC:mah] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "negative regulation of T cell development in thymus" RELATED [GOC:add] synonym: "negative regulation of thymic T cell differentiation" EXACT [] synonym: "negative regulation of thymocyte cell differentiation" EXACT [] synonym: "negative regulation of thymocyte differentiation" EXACT [] is_a: GO:0033081 ! regulation of T cell differentiation in thymus is_a: GO:0045581 ! negative regulation of T cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0033077 ! negatively regulates T cell differentiation in thymus relationship: RO:0002212 GO:0033077 ! negatively regulates T cell differentiation in thymus [Term] id: GO:0033087 name: negative regulation of immature T cell proliferation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of immature T cell proliferation." [GOC:add, GOC:mah] is_a: GO:0033083 ! regulation of immature T cell proliferation is_a: GO:0042130 ! negative regulation of T cell proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0033079 ! negatively regulates immature T cell proliferation relationship: RO:0002212 GO:0033079 ! negatively regulates immature T cell proliferation [Term] id: GO:0033088 name: negative regulation of immature T cell proliferation in thymus namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of immature T cell proliferation in the thymus." [GOC:add, GOC:mah] synonym: "negative regulation of thymic T cell proliferation" EXACT [] synonym: "negative regulation of thymocyte cell proliferation" EXACT [] synonym: "negative regulation of thymocyte proliferation" EXACT [] is_a: GO:0033084 ! regulation of immature T cell proliferation in thymus is_a: GO:0033085 ! negative regulation of T cell differentiation in thymus is_a: GO:0033087 ! negative regulation of immature T cell proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0033080 ! negatively regulates immature T cell proliferation in thymus relationship: RO:0002212 GO:0033080 ! negatively regulates immature T cell proliferation in thymus [Term] id: GO:0033089 name: positive regulation of T cell differentiation in thymus namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of T cell differentiation in the thymus." [GOC:add, GOC:mah] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "positive regulation of T cell development in thymus" RELATED [GOC:add] synonym: "positive regulation of thymic T cell differentiation" EXACT [] synonym: "positive regulation of thymocyte cell differentiation" EXACT [] synonym: "positive regulation of thymocyte differentiation" EXACT [] is_a: GO:0033081 ! regulation of T cell differentiation in thymus is_a: GO:0045582 ! positive regulation of T cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0033077 ! positively regulates T cell differentiation in thymus relationship: RO:0002213 GO:0033077 ! positively regulates T cell differentiation in thymus [Term] id: GO:0033091 name: positive regulation of immature T cell proliferation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of immature T cell proliferation." [GOC:add, GOC:mah] is_a: GO:0033083 ! regulation of immature T cell proliferation is_a: GO:0042102 ! positive regulation of T cell proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0033079 ! positively regulates immature T cell proliferation relationship: RO:0002213 GO:0033079 ! positively regulates immature T cell proliferation [Term] id: GO:0033092 name: positive regulation of immature T cell proliferation in thymus namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of immature T cell proliferation in the thymus." [GOC:add, GOC:mah] synonym: "positive regulation of thymic T cell proliferation" EXACT [] synonym: "positive regulation of thymocyte cell proliferation" EXACT [] synonym: "positive regulation of thymocyte proliferation" EXACT [] is_a: GO:0033084 ! regulation of immature T cell proliferation in thymus is_a: GO:0033091 ! positive regulation of immature T cell proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0033080 ! positively regulates immature T cell proliferation in thymus relationship: RO:0002213 GO:0033080 ! positively regulates immature T cell proliferation in thymus [Term] id: GO:0033093 name: Weibel-Palade body namespace: cellular_component def: "A large, elongated, rod-shaped secretory granule characteristic of vascular endothelial cells that contain a number of structurally and functionally distinct proteins, of which the best characterized are von Willebrand factor (VWF) and P-selectin. Weibel-Palade bodies are formed from the trans-Golgi network in a process that depends on VWF, which is densely packed in a highly organized manner, and on coat proteins that remain associated with the granules. Upon cell stimulation, regulated exocytosis releases the contained proteins to the cell surface, where they act in the recruitment of platelets and leukocytes and in inflammatory and vasoactive responses." [PMID:11935287, PMID:16087708] xref: Wikipedia:Weibel-Palade_body is_a: GO:0030136 ! clathrin-coated vesicle is_a: GO:0030141 ! secretory granule property_value: RO:0002161 NCBITaxon:4890 [Term] id: GO:0033121 name: regulation of purine nucleotide catabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of purine nucleotides." [GOC:mah] synonym: "regulation of purine nucleotide breakdown" EXACT [] synonym: "regulation of purine nucleotide catabolism" EXACT [] synonym: "regulation of purine nucleotide degradation" EXACT [] is_a: GO:0030811 ! regulation of nucleotide catabolic process is_a: GO:1900542 ! regulation of purine nucleotide metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0006195 ! regulates purine nucleotide catabolic process relationship: RO:0002211 GO:0006195 ! regulates purine nucleotide catabolic process [Term] id: GO:0033122 name: negative regulation of purine nucleotide catabolic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of purine nucleotides." [GOC:mah] synonym: "negative regulation of purine nucleotide breakdown" EXACT [] synonym: "negative regulation of purine nucleotide catabolism" EXACT [] synonym: "negative regulation of purine nucleotide degradation" EXACT [] is_a: GO:0030812 ! negative regulation of nucleotide catabolic process is_a: GO:0033121 ! regulation of purine nucleotide catabolic process is_a: GO:1900543 ! negative regulation of purine nucleotide metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0006195 ! negatively regulates purine nucleotide catabolic process relationship: RO:0002212 GO:0006195 ! negatively regulates purine nucleotide catabolic process [Term] id: GO:0033123 name: positive regulation of purine nucleotide catabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of purine nucleotides." [GOC:mah] synonym: "positive regulation of purine nucleotide breakdown" EXACT [] synonym: "positive regulation of purine nucleotide catabolism" EXACT [] synonym: "positive regulation of purine nucleotide degradation" EXACT [] is_a: GO:0030813 ! positive regulation of nucleotide catabolic process is_a: GO:0033121 ! regulation of purine nucleotide catabolic process is_a: GO:1900544 ! positive regulation of purine nucleotide metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0006195 ! positively regulates purine nucleotide catabolic process relationship: RO:0002213 GO:0006195 ! positively regulates purine nucleotide catabolic process [Term] id: GO:0033151 name: V(D)J recombination namespace: biological_process def: "The process in which immune receptor V, D, and J, or V and J gene segments, depending on the specific receptor, are recombined within a single locus utilizing the conserved heptamer and nonomer recombination signal sequences (RSS)." [GOC:add, ISBN:0781700221, ISBN:0781735149] synonym: "V(D)J joining" EXACT [] synonym: "V-D-J joining" EXACT [] synonym: "V-D-J recombination" EXACT [] synonym: "V-J joining" EXACT [] synonym: "V-J recombination" EXACT [] xref: Wikipedia:V(D)J_recombination is_a: GO:0002562 ! somatic diversification of immune receptors via germline recombination within a single locus property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4751 [Term] id: GO:0033152 name: immunoglobulin V(D)J recombination namespace: biological_process def: "The process in which immunoglobulin gene segments are recombined within a single locus utilizing the conserved heptamer and nonomer recombination signal sequences (RSS). For immunoglobulin heavy chains V, D, and J gene segments are joined, and for immunoglobulin light chains V and J gene segments are joined." [GOC:add, ISBN:0781735149] synonym: "immunoglobulin V(D)J joining" EXACT [GOC:add] synonym: "immunoglobulin V-D-J joining" NARROW [GOC:add] synonym: "immunoglobulin V-D-J recombination" NARROW [GOC:add] synonym: "immunoglobulin V-J joining" NARROW [GOC:add] synonym: "immunoglobulin V-J recombination" NARROW [GOC:add] is_a: GO:0016447 ! somatic recombination of immunoglobulin gene segments is_a: GO:0033151 ! V(D)J recombination property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4751 [Term] id: GO:0033157 name: regulation of intracellular protein transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the directed movement of proteins within cells." [GOC:mah] is_a: GO:0032386 ! regulation of intracellular transport is_a: GO:0051223 ! regulation of protein transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0006886 ! regulates intracellular protein transport relationship: RO:0002211 GO:0006886 ! regulates intracellular protein transport [Term] id: GO:0033162 name: melanosome membrane namespace: cellular_component def: "The lipid bilayer surrounding a melanosome." [GOC:mah] is_a: GO:0090741 ! pigment granule membrane intersection_of: GO:0016020 ! membrane intersection_of: RO:0002007 GO:0042470 ! bounding layer of melanosome relationship: BFO:0000050 GO:0045009 ! part of chitosome relationship: RO:0002007 GO:0042470 ! bounding layer of melanosome [Term] id: GO:0033198 name: response to ATP namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ATP (adenosine 5'-triphosphate) stimulus." [GOC:sl] synonym: "response to adenosine 5'-triphosphate" EXACT [] synonym: "response to adenosine triphosphate" EXACT [] is_a: GO:0014074 ! response to purine-containing compound is_a: GO:0046683 ! response to organophosphorus is_a: GO:1901700 ! response to oxygen-containing compound intersection_of: GO:0050896 ! response to stimulus intersection_of: RO:0004009 CHEBI:30616 ! has primary input relationship: RO:0004009 CHEBI:30616 ! has primary input [Term] id: GO:0033212 name: iron import into cell namespace: biological_process def: "The directed movement of iron ions from outside of a cell into the cytoplasmic compartment. This may occur via transport across the plasma membrane or via endocytosis." [PMID:18622392, PMID:23192658, Wikipedia:Human_iron_metabolism] synonym: "ferrous ion import" NARROW [] synonym: "ferrous iron import" NARROW [] synonym: "ferrous iron uptake" NARROW [] synonym: "iron assimilation" RELATED [] is_a: GO:0006826 ! iron ion transport is_a: GO:0006879 ! intracellular iron ion homeostasis is_a: GO:0051649 ! establishment of localization in cell intersection_of: GO:0006810 ! transport intersection_of: RO:0002338 GO:0005576 ! has target start location extracellular region intersection_of: RO:0002339 GO:0005622 ! has target end location intracellular anatomical structure intersection_of: RO:0004009 CHEBI:24875 ! has primary input relationship: RO:0002338 GO:0005576 ! has target start location extracellular region relationship: RO:0002339 GO:0005622 ! has target end location intracellular anatomical structure creation_date: 2009-05-01T04:19:14Z [Term] id: GO:0033218 name: amide binding namespace: molecular_function def: "Binding to an amide, any derivative of an oxoacid in which an acidic hydroxy group has been replaced by an amino or substituted amino group." [GOC:mah] subset: goslim_pir is_a: BFO:0000003 is_a: GO:0005488 ! binding intersection_of: GO:0005488 ! binding intersection_of: RO:0004009 CHEBI:32988 ! has primary input relationship: RO:0004009 CHEBI:32988 ! has primary input [Term] id: GO:0033238 name: regulation of amine metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform amines." [GOC:mah] synonym: "regulation of amine metabolism" EXACT [] synonym: "regulation of cellular amine metabolic process" EXACT [] is_a: GO:0019222 ! regulation of metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0009308 ! regulates amine metabolic process relationship: RO:0002211 GO:0009308 ! regulates amine metabolic process [Term] id: GO:0033239 name: negative regulation of amine metabolic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving amines." [GOC:mah] synonym: "negative regulation of amine metabolism" EXACT [] synonym: "negative regulation of cellular amine metabolic process" EXACT [] is_a: GO:0009892 ! negative regulation of metabolic process is_a: GO:0033238 ! regulation of amine metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0009308 ! negatively regulates amine metabolic process relationship: RO:0002212 GO:0009308 ! negatively regulates amine metabolic process [Term] id: GO:0033240 name: positive regulation of amine metabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving amines." [GOC:mah] synonym: "positive regulation of amine metabolism" EXACT [] synonym: "positive regulation of cellular amine metabolic process" EXACT [] is_a: GO:0009893 ! positive regulation of metabolic process is_a: GO:0033238 ! regulation of amine metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0009308 ! positively regulates amine metabolic process relationship: RO:0002213 GO:0009308 ! positively regulates amine metabolic process [Term] id: GO:0033241 name: regulation of amine catabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways leading to the breakdown of amines." [GOC:mah] synonym: "regulation of amine breakdown" EXACT [] synonym: "regulation of amine catabolism" EXACT [] synonym: "regulation of amine degradation" EXACT [] synonym: "regulation of cellular amine catabolic process" EXACT [] is_a: GO:0009894 ! regulation of catabolic process is_a: GO:0033238 ! regulation of amine metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0009310 ! regulates amine catabolic process relationship: RO:0002211 GO:0009310 ! regulates amine catabolic process [Term] id: GO:0033242 name: negative regulation of amine catabolic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways leading to the breakdown of amines." [GOC:mah] synonym: "negative regulation of amine breakdown" EXACT [] synonym: "negative regulation of amine catabolism" EXACT [] synonym: "negative regulation of amine degradation" EXACT [] synonym: "negative regulation of cellular amine catabolic process" EXACT [] is_a: GO:0009895 ! negative regulation of catabolic process is_a: GO:0033239 ! negative regulation of amine metabolic process is_a: GO:0033241 ! regulation of amine catabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0009310 ! negatively regulates amine catabolic process relationship: RO:0002212 GO:0009310 ! negatively regulates amine catabolic process [Term] id: GO:0033243 name: positive regulation of amine catabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways leading to the breakdown of amines." [GOC:mah] synonym: "positive regulation of amine breakdown" EXACT [] synonym: "positive regulation of amine catabolism" EXACT [] synonym: "positive regulation of amine degradation" EXACT [] is_a: GO:0009896 ! positive regulation of catabolic process is_a: GO:0033240 ! positive regulation of amine metabolic process is_a: GO:0033241 ! regulation of amine catabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0009310 ! positively regulates amine catabolic process relationship: RO:0002213 GO:0009310 ! positively regulates amine catabolic process [Term] id: GO:0033278 name: cell proliferation in midbrain namespace: biological_process def: "The multiplication or reproduction of cells, resulting in the expansion of a cell population in the midbrain." [GO_REF:0000021, GOC:dgf] synonym: "cell proliferation in mesencephalon" EXACT [] synonym: "mesencepahalic cell proliferation" RELATED [] is_a: BFO:0000003 is_a: GO:0061351 ! neural precursor cell proliferation intersection_of: GO:0008283 ! cell population proliferation intersection_of: BFO:0000066 UBERON:0001891 ! occurs in midbrain relationship: BFO:0000050 GO:0030901 ! part of midbrain development relationship: BFO:0000066 UBERON:0001891 ! occurs in midbrain [Term] id: GO:0033293 name: monocarboxylic acid binding namespace: molecular_function def: "Binding to a monocarboxylic acid, any organic acid containing one carboxyl (COOH) group or anion (COO-)." [GOC:mah] is_a: GO:0031406 ! carboxylic acid binding intersection_of: GO:0005488 ! binding intersection_of: RO:0004009 CHEBI:35757 ! has primary input relationship: RO:0004009 CHEBI:35757 ! has primary input [Term] id: GO:0033326 name: cerebrospinal fluid secretion namespace: biological_process def: "The regulated release of cerebrospinal fluid (CSF) from the choroid plexus of the lateral, third and fourth ventricles. The cerebrospinal fluid is a clear liquid that located within the ventricles, spinal canal, and subarachnoid spaces." [GOC:ln, PMID:10716451] synonym: "CSF secretion" EXACT [] is_a: GO:0007589 ! body fluid secretion is_a: GO:0032941 ! secretion by tissue property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0033327 name: Leydig cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized structural and/or functional features of a Leydig cell. A Leydig cell is a testosterone-secreting cell in the interstitial area, between the seminiferous tubules, in the testis." [GOC:ln, PMID:12050120] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0030154 ! cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000178 ! results in acquisition of features of Leydig cell relationship: BFO:0000050 GO:0008584 ! part of male gonad development relationship: RO:0002162 NCBITaxon:7742 ! in taxon Vertebrata relationship: RO:0002315 CL:0000178 ! results in acquisition of features of Leydig cell [Term] id: GO:0033363 name: secretory granule organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a secretory granule. A secretory granule is a small subcellular vesicle, surrounded by a membrane, that is formed from the Golgi apparatus and contains a highly concentrated protein destined for secretion." [GOC:mah] synonym: "secretory granule organisation" EXACT [GOC:mah] synonym: "secretory granule organization and biogenesis" RELATED [GOC:mah] is_a: GO:0016050 ! vesicle organization intersection_of: GO:0016043 ! cellular component organization intersection_of: RO:0002592 GO:0030141 ! results in organization of secretory granule relationship: BFO:0000050 GO:0010256 ! part of endomembrane system organization relationship: RO:0002592 GO:0030141 ! results in organization of secretory granule [Term] id: GO:0033364 name: mast cell secretory granule organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a secretory granule in a mast cell. A secretory granule is a small subcellular vesicle, surrounded by a membrane, that is formed from the Golgi apparatus and contains a highly concentrated protein destined for secretion." [GOC:mah] synonym: "mast cell secretory granule maturation" RELATED [] synonym: "mast cell secretory granule organisation" EXACT [GOC:mah] synonym: "mast cell secretory granule organization and biogenesis" RELATED [GOC:mah] is_a: GO:0033363 ! secretory granule organization intersection_of: GO:0016043 ! cellular component organization intersection_of: BFO:0000066 CL:0000097 ! occurs in mast cell intersection_of: RO:0002592 GO:0030141 ! results in organization of secretory granule relationship: BFO:0000066 CL:0000097 ! occurs in mast cell [Term] id: GO:0033365 name: protein localization to organelle namespace: biological_process def: "A process in which a protein is transported to, or maintained in, a location within an organelle." [GOC:mah] subset: gocheck_do_not_annotate synonym: "protein localisation to organelle" EXACT [GOC:mah] synonym: "protein localization in organelle" EXACT [GOC:mah] is_a: GO:0008104 ! intracellular protein localization intersection_of: GO:0008104 ! intracellular protein localization intersection_of: RO:0002339 GO:0043226 ! has target end location organelle relationship: RO:0002339 GO:0043226 ! has target end location organelle [Term] id: GO:0033366 name: protein localization to secretory granule namespace: biological_process def: "A process in which a protein is transported to, or maintained in, a location within a secretory granule." [GOC:mah] synonym: "protein localisation in secretory granule" EXACT [GOC:mah] synonym: "protein localization in secretory granule" EXACT [] is_a: GO:0033365 ! protein localization to organelle intersection_of: GO:0008104 ! intracellular protein localization intersection_of: RO:0002339 GO:0030141 ! has target end location secretory granule relationship: RO:0002339 GO:0030141 ! has target end location secretory granule [Term] id: GO:0033371 name: T cell secretory granule organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a secretory granule in a T cell. A secretory granule is a small subcellular vesicle, surrounded by a membrane, that is formed from the Golgi apparatus and contains a highly concentrated protein destined for secretion." [GOC:mah] synonym: "T cell secretory granule organisation" EXACT [GOC:mah] synonym: "T cell secretory granule organization and biogenesis" RELATED [GOC:mah] synonym: "T lymphocyte secretory granule organization" EXACT [] synonym: "T-cell secretory granule organization" EXACT [] synonym: "T-lymphocyte secretory granule maturation" RELATED [] synonym: "T-lymphocyte secretory granule organization" EXACT [] is_a: GO:0033363 ! secretory granule organization intersection_of: GO:0016043 ! cellular component organization intersection_of: BFO:0000066 CL:0000084 ! occurs in T cell intersection_of: RO:0002592 GO:0030141 ! results in organization of secretory granule relationship: BFO:0000066 CL:0000084 ! occurs in T cell [Term] id: GO:0033374 name: protein localization to T cell secretory granule namespace: biological_process def: "A process in which a protein is transported to, or maintained in, a location within a secretory granule in a T cell." [GOC:mah] synonym: "protein localisation in T cell secretory granule" EXACT [GOC:mah] synonym: "protein localization in T cell secretory granule" EXACT [] synonym: "protein localization in T lymphocyte secretory granule" EXACT [] synonym: "protein localization in T-cell secretory granule" EXACT [] synonym: "protein localization in T-lymphocyte secretory granule" EXACT [] is_a: GO:0033366 ! protein localization to secretory granule relationship: BFO:0000050 GO:0033371 ! part of T cell secretory granule organization [Term] id: GO:0033375 name: protease localization to T cell secretory granule namespace: biological_process def: "Any process in which a protease is transported to, or maintained in, a location within a secretory granule in a T cell." [GOC:mah] synonym: "protease localisation in T cell secretory granule" EXACT [GOC:mah] synonym: "protease localization in T cell secretory granule" EXACT [] synonym: "protease localization in T lymphocyte secretory granule" EXACT [] synonym: "protease localization in T-cell secretory granule" EXACT [] synonym: "protease localization in T-lymphocyte secretory granule" EXACT [] is_a: GO:0033374 ! protein localization to T cell secretory granule [Term] id: GO:0033380 name: granzyme B localization to T cell secretory granule namespace: biological_process def: "Any process in which the protease granzyme B is transported to, or maintained in, a location within a secretory granule in a T cell." [GOC:mah] synonym: "granzyme B localisation in T cell secretory granule" EXACT [GOC:mah] synonym: "granzyme B localization in T cell secretory granule" EXACT [] synonym: "granzyme B localization in T lymphocyte secretory granule" EXACT [] synonym: "granzyme B localization in T-cell secretory granule" EXACT [] synonym: "granzyme B localization in T-lymphocyte secretory granule" EXACT [] is_a: GO:0033375 ! protease localization to T cell secretory granule [Term] id: GO:0033484 name: intracellular nitric oxide homeostasis namespace: biological_process def: "A homeostatic process involved in the maintenance of a steady state level of nitric oxide within a cell." [GOC:mah] synonym: "cellular nitric oxide homeostasis" EXACT [] synonym: "nitric oxide homeostasis" BROAD [] synonym: "NO homeostasis" BROAD [] is_a: GO:0055082 ! intracellular chemical homeostasis intersection_of: GO:0055082 ! intracellular chemical homeostasis intersection_of: RO:0002332 CHEBI:16480 ! regulates levels of relationship: RO:0002332 CHEBI:16480 ! regulates levels of property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/24224" xsd:anyURI [Term] id: GO:0033500 name: carbohydrate homeostasis namespace: biological_process def: "A homeostatic process involved in the maintenance of an internal steady state of a carbohydrate within an organism or cell." [GOC:mah] is_a: GO:0048878 ! chemical homeostasis intersection_of: GO:0048878 ! chemical homeostasis intersection_of: RO:0002332 CHEBI:16646 ! regulates levels of relationship: RO:0002332 CHEBI:16646 ! regulates levels of [Term] id: GO:0033504 name: floor plate development namespace: biological_process def: "The progression of the floor plate over time from its initial formation until its mature state." [GOC:dh] is_a: GO:0048856 ! anatomical structure development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0003306 ! results in development of floor plate of neural tube relationship: BFO:0000050 GO:0021915 ! part of neural tube development relationship: RO:0002296 UBERON:0003306 ! results in development of floor plate of neural tube [Term] id: GO:0033505 name: floor plate morphogenesis namespace: biological_process def: "The process in which the anatomical structure of the floor plate is generated and organized." [GOC:dh] is_a: GO:0048598 ! embryonic morphogenesis is_a: GO:0048729 ! tissue morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0003079 ! results in morphogenesis of floor plate relationship: BFO:0000050 GO:0033504 ! part of floor plate development relationship: RO:0002298 UBERON:0003079 ! results in morphogenesis of floor plate [Term] id: GO:0033554 name: cellular response to stress namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:mah] xref: Reactome:R-HSA-2262752 "Cellular responses to stress" is_a: GO:0006950 ! response to stress is_a: GO:0051716 ! cellular response to stimulus property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/26810" xsd:anyURI [Term] id: GO:0033568 name: lactoferrin receptor activity namespace: molecular_function def: "Combining with lactoferrin and delivering lactoferrin into the cell via endocytosis. Lactoferrin is an iron-binding glycoprotein which binds ferric iron most efficiently at low pH." [GOC:bf, GOC:mlg, PMID:16261254] is_a: BFO:0000003 is_a: GO:0038024 ! cargo receptor activity intersection_of: GO:0038024 ! cargo receptor activity intersection_of: RO:0004009 PR:000009978 ! has primary input lactotransferrin relationship: RO:0004009 PR:000009978 ! has primary input lactotransferrin [Term] id: GO:0033569 name: lactoferrin transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of lactoferrin from one side of a membrane to the other." [GOC:mlg] is_a: GO:0008320 ! protein transmembrane transporter activity intersection_of: GO:0022857 ! transmembrane transporter activity intersection_of: RO:0004009 PR:000009978 ! has primary input lactotransferrin relationship: BFO:0000050 GO:0033571 ! part of lactoferrin transport relationship: RO:0004009 PR:000009978 ! has primary input lactotransferrin [Term] id: GO:0033571 name: lactoferrin transport namespace: biological_process def: "The directed movement of lactoferrin into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mlg] is_a: GO:0006826 ! iron ion transport is_a: GO:0015031 ! protein transport intersection_of: GO:0006810 ! transport intersection_of: RO:0004009 PR:000009978 ! has primary input lactotransferrin relationship: RO:0004009 PR:000009978 ! has primary input lactotransferrin [Term] id: GO:0033574 name: response to testosterone namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a testosterone stimulus." [GOC:sl] synonym: "response to testosterone stimulus" EXACT [GOC:dos] is_a: GO:0033993 ! response to lipid is_a: GO:1901654 ! response to ketone intersection_of: GO:0050896 ! response to stimulus intersection_of: RO:0004009 CHEBI:17347 ! has primary input relationship: RO:0004009 CHEBI:17347 ! has primary input [Term] id: GO:0033602 name: negative regulation of dopamine secretion namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of dopamine." [GOC:sl] synonym: "down regulation of dopamine secretion" EXACT [] synonym: "down-regulation of dopamine secretion" EXACT [] synonym: "downregulation of dopamine secretion" EXACT [] synonym: "inhibition of dopamine secretion" NARROW [] is_a: GO:0014059 ! regulation of dopamine secretion is_a: GO:0033604 ! negative regulation of catecholamine secretion intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0014046 ! negatively regulates dopamine secretion relationship: RO:0002212 GO:0014046 ! negatively regulates dopamine secretion [Term] id: GO:0033603 name: positive regulation of dopamine secretion namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the regulated release of dopamine." [GOC:sl] synonym: "activation of dopamine secretion" NARROW [] synonym: "stimulation of dopamine secretion" NARROW [] synonym: "up regulation of dopamine secretion" EXACT [] synonym: "up-regulation of dopamine secretion" EXACT [] synonym: "upregulation of dopamine secretion" EXACT [] is_a: GO:0014059 ! regulation of dopamine secretion is_a: GO:0033605 ! positive regulation of catecholamine secretion intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0014046 ! positively regulates dopamine secretion relationship: RO:0002213 GO:0014046 ! positively regulates dopamine secretion [Term] id: GO:0033604 name: negative regulation of catecholamine secretion namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of a catecholamine." [GOC:mah] synonym: "down regulation of catecholamine secretion" EXACT [] synonym: "down-regulation of catecholamine secretion" EXACT [] synonym: "downregulation of catecholamine secretion" EXACT [] synonym: "inhibition of catecholamine secretion" NARROW [] is_a: GO:0050433 ! regulation of catecholamine secretion is_a: GO:0051953 ! negative regulation of amine transport is_a: GO:1903531 ! negative regulation of secretion by cell intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0050432 ! negatively regulates catecholamine secretion relationship: RO:0002212 GO:0050432 ! negatively regulates catecholamine secretion [Term] id: GO:0033605 name: positive regulation of catecholamine secretion namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the regulated release of a catecholamine." [GOC:mah] synonym: "activation of catecholamine secretion" NARROW [] synonym: "stimulation of catecholamine secretion" NARROW [] synonym: "up regulation of catecholamine secretion" EXACT [] synonym: "up-regulation of catecholamine secretion" EXACT [] synonym: "upregulation of catecholamine secretion" EXACT [] is_a: GO:0050433 ! regulation of catecholamine secretion is_a: GO:0051954 ! positive regulation of amine transport is_a: GO:1903532 ! positive regulation of secretion by cell intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0050432 ! positively regulates catecholamine secretion relationship: RO:0002213 GO:0050432 ! positively regulates catecholamine secretion [Term] id: GO:0033673 name: negative regulation of kinase activity namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [GOC:mah] subset: gocheck_obsoletion_candidate synonym: "down regulation of kinase activity" EXACT [] synonym: "down-regulation of kinase activity" EXACT [] synonym: "downregulation of kinase activity" EXACT [] synonym: "inhibition of kinase activity" NARROW [] synonym: "kinase inhibitor" NARROW [] is_a: GO:0042326 ! negative regulation of phosphorylation is_a: GO:0043086 ! negative regulation of catalytic activity is_a: GO:0043549 ! regulation of kinase activity intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0016301 ! negatively regulates kinase activity relationship: RO:0002212 GO:0016301 ! negatively regulates kinase activity [Term] id: GO:0033674 name: positive regulation of kinase activity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [GOC:mah] subset: gocheck_obsoletion_candidate synonym: "kinase activator" NARROW [] synonym: "stimulation of kinase activity" NARROW [] synonym: "up regulation of kinase activity" EXACT [] synonym: "up-regulation of kinase activity" EXACT [] synonym: "upregulation of kinase activity" EXACT [] is_a: GO:0042327 ! positive regulation of phosphorylation is_a: GO:0043085 ! positive regulation of catalytic activity is_a: GO:0043549 ! regulation of kinase activity intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0016301 ! positively regulates kinase activity relationship: RO:0002213 GO:0016301 ! positively regulates kinase activity [Term] id: GO:0033684 name: regulation of luteinizing hormone secretion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the regulated release of luteinizing hormone." [GOC:mah] is_a: GO:0032276 ! regulation of gonadotropin secretion intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0032275 ! regulates luteinizing hormone secretion relationship: RO:0002211 GO:0032275 ! regulates luteinizing hormone secretion property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0033685 name: negative regulation of luteinizing hormone secretion namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of luteinizing hormone." [GOC:mah] synonym: "down regulation of luteinizing hormone secretion" EXACT [] synonym: "down-regulation of luteinizing hormone secretion" EXACT [] synonym: "downregulation of luteinizing hormone secretion" EXACT [] synonym: "inhibition of luteinizing hormone secretion" NARROW [] is_a: GO:0032277 ! negative regulation of gonadotropin secretion is_a: GO:0033684 ! regulation of luteinizing hormone secretion intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0032275 ! negatively regulates luteinizing hormone secretion relationship: RO:0002212 GO:0032275 ! negatively regulates luteinizing hormone secretion property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0033686 name: positive regulation of luteinizing hormone secretion namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the regulated release of luteinizing hormone." [GOC:mah] synonym: "activation of luteinizing hormone secretion" NARROW [] synonym: "stimulation of luteinizing hormone secretion" NARROW [] synonym: "up regulation of luteinizing hormone secretion" EXACT [] synonym: "up-regulation of luteinizing hormone secretion" EXACT [] synonym: "upregulation of luteinizing hormone secretion" EXACT [] is_a: GO:0032278 ! positive regulation of gonadotropin secretion is_a: GO:0033684 ! regulation of luteinizing hormone secretion intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0032275 ! positively regulates luteinizing hormone secretion relationship: RO:0002213 GO:0032275 ! positively regulates luteinizing hormone secretion property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0033687 name: osteoblast proliferation namespace: biological_process def: "The multiplication or reproduction of osteoblasts, resulting in the expansion of an osteoblast cell population. An osteoblast is a bone-forming cell which secretes an extracellular matrix. Hydroxyapatite crystals are then deposited into the matrix to form bone." [GOC:mah] is_a: BFO:0000003 is_a: GO:0008283 ! cell population proliferation intersection_of: GO:0008283 ! cell population proliferation intersection_of: RO:0012003 CL:0000062 ! acts on population of osteoblast relationship: RO:0012003 CL:0000062 ! acts on population of osteoblast property_value: RO:0002161 NCBITaxon:4751 [Term] id: GO:0033688 name: regulation of osteoblast proliferation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of osteoblast proliferation." [GOC:mah] is_a: GO:0042127 ! regulation of cell population proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0033687 ! regulates osteoblast proliferation relationship: RO:0002211 GO:0033687 ! regulates osteoblast proliferation property_value: RO:0002161 NCBITaxon:4751 [Term] id: GO:0033689 name: negative regulation of osteoblast proliferation namespace: biological_process def: "Any process that stops, prevents or reduces the rate or extent of osteoblast proliferation." [GOC:mah] synonym: "down regulation of osteoblast proliferation" EXACT [] synonym: "down-regulation of osteoblast proliferation" EXACT [] synonym: "downregulation of osteoblast proliferation" EXACT [] synonym: "inhibition of osteoblast proliferation" NARROW [] is_a: GO:0008285 ! negative regulation of cell population proliferation is_a: GO:0033688 ! regulation of osteoblast proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0033687 ! negatively regulates osteoblast proliferation relationship: RO:0002212 GO:0033687 ! negatively regulates osteoblast proliferation property_value: RO:0002161 NCBITaxon:4751 [Term] id: GO:0033690 name: positive regulation of osteoblast proliferation namespace: biological_process def: "Any process that activates or increases the rate or extent of osteoblast proliferation." [GOC:mah] synonym: "activation of osteoblast proliferation" NARROW [] synonym: "stimulation of osteoblast proliferation" NARROW [] synonym: "up regulation of osteoblast proliferation" EXACT [] synonym: "up-regulation of osteoblast proliferation" EXACT [] synonym: "upregulation of osteoblast proliferation" EXACT [] is_a: GO:0008284 ! positive regulation of cell population proliferation is_a: GO:0033688 ! regulation of osteoblast proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0033687 ! positively regulates osteoblast proliferation relationship: RO:0002213 GO:0033687 ! positively regulates osteoblast proliferation property_value: RO:0002161 NCBITaxon:4751 [Term] id: GO:0033696 name: heterochromatin boundary formation namespace: biological_process def: "A process that forms a boundary that limits the spreading of heterochromatin along a chromosome." [GOC:mah] synonym: "maintenance of heterochromatin boundaries" RELATED [] synonym: "negative regulation of extent of heterochromatin assembly" RELATED [] synonym: "negative regulation of extent of heterochromatin formation" RELATED [] synonym: "negative regulation of heterochromatin spreading" RELATED [] synonym: "regulation of extent of heterochromatin assembly" RELATED [] synonym: "regulation of extent of heterochromatin formation" EXACT [] synonym: "regulation of heterochromatin spreading" RELATED [] is_a: GO:0070828 ! heterochromatin organization relationship: BFO:0000050 GO:0031507 ! part of heterochromatin formation property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/22028" xsd:anyURI [Term] id: GO:0033750 name: ribosome localization namespace: biological_process def: "A process in which a ribosome is transported to, and/or maintained in, a specific location." [GOC:mah] synonym: "establishment of ribosome localisation" RELATED [] synonym: "establishment of ribosome localization" RELATED [] synonym: "ribosome localisation" RELATED [] is_a: GO:0051640 ! organelle localization intersection_of: GO:0051179 ! localization intersection_of: RO:0004009 GO:0005840 ! has primary input ribosome relationship: RO:0004009 GO:0005840 ! has primary input ribosome [Term] id: GO:0033762 name: response to glucagon namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucagon stimulus." [GOC:sl] synonym: "response to glucagon stimulus" EXACT [GOC:dos] is_a: GO:0043434 ! response to peptide hormone intersection_of: GO:0050896 ! response to stimulus intersection_of: RO:0004009 CHEBI:5391 ! has primary input relationship: RO:0004009 CHEBI:5391 ! has primary input property_value: RO:0002161 NCBITaxon:4751 [Term] id: GO:0033993 name: response to lipid namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipid stimulus." [GOC:sl] is_a: GO:0042221 ! response to chemical intersection_of: GO:0050896 ! response to stimulus intersection_of: RO:0004009 CHEBI:18059 ! has primary input relationship: RO:0004009 CHEBI:18059 ! has primary input [Term] id: GO:0034067 name: protein localization to Golgi apparatus namespace: biological_process def: "A process in which a protein is transported to, or maintained in, a location within the Golgi apparatus." [GOC:mah] synonym: "establishment of protein localisation to Golgi" NARROW [GOC:mah] synonym: "establishment of protein localization in Golgi" NARROW [] synonym: "establishment of protein localization to Golgi" NARROW [] synonym: "establishment of protein localization to Golgi apparatus" NARROW [GOC:mah] synonym: "protein localisation in Golgi apparatus" EXACT [GOC:mah] synonym: "protein localization in Golgi apparatus" EXACT [] synonym: "protein targeting to Golgi" RELATED [] synonym: "protein-Golgi targeting" RELATED [] is_a: GO:0033365 ! protein localization to organelle intersection_of: GO:0008104 ! intracellular protein localization intersection_of: RO:0002339 GO:0005794 ! has target end location Golgi apparatus relationship: RO:0002339 GO:0005794 ! has target end location Golgi apparatus creation_date: 2011-02-14T02:26:36Z [Term] id: GO:0034097 name: response to cytokine namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cytokine stimulus." [GOC:sl] synonym: "response to cytokine stimulus" EXACT [GOC:dos] xref: Reactome:R-HSA-9645135 "STAT5 Activation" is_a: GO:1901652 ! response to peptide [Term] id: GO:0034101 name: erythrocyte homeostasis namespace: biological_process def: "Any process of regulating the production and elimination of erythrocytes within an organism." [GOC:add, PMID:10694114, PMID:14754397] synonym: "RBC homeostasis" EXACT [CL:0000232] synonym: "red blood cell homeostasis" EXACT [CL:0000232] is_a: GO:0002262 ! myeloid cell homeostasis intersection_of: GO:0048872 ! homeostasis of number of cells intersection_of: RO:0012003 CL:0000232 ! acts on population of erythrocyte relationship: RO:0012003 CL:0000232 ! acts on population of erythrocyte property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4895 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0034102 name: erythrocyte clearance namespace: biological_process def: "The selective elimination of erythrocytes from the body by autoregulatory mechanisms." [GOC:add, PMID:12905029, PMID:14754397] comment: Note that this term is intended for annotation of self-gene products that lead to elimination of erythrocytes without the involvement of a symbiont. synonym: "neocytolysis" NARROW [PMID:14754397] synonym: "RBC clearance" EXACT [CL:0000232] synonym: "red blood cell clearance" EXACT [CL:0000232] is_a: GO:0048771 ! tissue remodeling relationship: BFO:0000050 GO:0034101 ! part of erythrocyte homeostasis property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4895 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0034103 name: regulation of tissue remodeling namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of tissue remodeling." [GOC:add] synonym: "regulation of tissue remodelling" EXACT [] is_a: GO:0051239 ! regulation of multicellular organismal process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0048771 ! regulates tissue remodeling relationship: RO:0002211 GO:0048771 ! regulates tissue remodeling property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0034104 name: negative regulation of tissue remodeling namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of tissue remodeling." [GOC:add] synonym: "negative regulation of tissue remodelling" EXACT [] is_a: GO:0034103 ! regulation of tissue remodeling is_a: GO:0051241 ! negative regulation of multicellular organismal process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0048771 ! negatively regulates tissue remodeling relationship: RO:0002212 GO:0048771 ! negatively regulates tissue remodeling property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0034105 name: positive regulation of tissue remodeling namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of tissue remodeling." [GOC:add] synonym: "positive regulation of tissue remodelling" EXACT [] is_a: GO:0034103 ! regulation of tissue remodeling is_a: GO:0051240 ! positive regulation of multicellular organismal process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0048771 ! positively regulates tissue remodeling relationship: RO:0002213 GO:0048771 ! positively regulates tissue remodeling property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0034106 name: regulation of erythrocyte clearance namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of erythrocyte clearance." [GOC:add, PMID:12905029, PMID:14754397] synonym: "regulation of neocytolysis" NARROW [PMID:14754397] synonym: "regulation of RBC clearance" EXACT [CL:0000232] synonym: "regulation of red blood cell clearance" EXACT [CL:0000232] is_a: GO:0034103 ! regulation of tissue remodeling intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0034102 ! regulates erythrocyte clearance relationship: RO:0002211 GO:0034102 ! regulates erythrocyte clearance property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4895 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0034107 name: negative regulation of erythrocyte clearance namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of erythrocyte clearance." [GOC:add, PMID:12905029, PMID:14754397] synonym: "negative regulation of neocytolysis" NARROW [PMID:14754397] synonym: "negative regulation of RBC clearance" EXACT [CL:0000232] synonym: "negative regulation of red blood cell clearance" EXACT [CL:0000232] is_a: GO:0002683 ! negative regulation of immune system process is_a: GO:0034104 ! negative regulation of tissue remodeling is_a: GO:0034106 ! regulation of erythrocyte clearance intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0034102 ! negatively regulates erythrocyte clearance relationship: RO:0002212 GO:0034102 ! negatively regulates erythrocyte clearance property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4895 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0034108 name: positive regulation of erythrocyte clearance namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of erythrocyte clearance." [GOC:add, PMID:12905029, PMID:14754397] synonym: "positive regulation of neocytolysis" NARROW [PMID:14754397] synonym: "positive regulation of RBC clearance" EXACT [CL:0000232] synonym: "positive regulation of red blood cell clearance" EXACT [CL:0000232] is_a: GO:0002684 ! positive regulation of immune system process is_a: GO:0034105 ! positive regulation of tissue remodeling is_a: GO:0034106 ! regulation of erythrocyte clearance intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0034102 ! positively regulates erythrocyte clearance relationship: RO:0002213 GO:0034102 ! positively regulates erythrocyte clearance property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4895 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0034219 name: carbohydrate transmembrane transport namespace: biological_process def: "The process in which a carbohydrate is transported across a membrane." [GOC:mah] comment: Note that this term is not intended for use in annotating lateral movement within membranes. synonym: "carbohydrate membrane transport" EXACT [] synonym: "transmembrane carbohydrate transport" EXACT [GOC:dph, GOC:tb] is_a: GO:0008643 ! carbohydrate transport is_a: GO:0055085 ! transmembrane transport intersection_of: GO:0055085 ! transmembrane transport intersection_of: RO:0004009 CHEBI:16646 ! has primary input [Term] id: GO:0034220 name: monoatomic ion transmembrane transport namespace: biological_process def: "A process in which a monoatomic ion is transported across a membrane. Monatomic ions (also called simple ions) are ions consisting of exactly one atom." [GOC:mah] comment: Note that this term is not intended for use in annotating lateral movement within membranes. synonym: "ATP hydrolysis coupled ion transmembrane transport" NARROW [] synonym: "ion membrane transport" EXACT [] synonym: "ion transmembrane transport" BROAD [] synonym: "transmembrane ion transport" EXACT [GOC:dph, GOC:tb] xref: Reactome:R-HSA-983712 "Ion channel transport" is_a: GO:0006811 ! monoatomic ion transport is_a: GO:0055085 ! transmembrane transport intersection_of: GO:0055085 ! transmembrane transport intersection_of: RO:0004009 CHEBI:24867 ! has primary input [Term] id: GO:0034242 name: negative regulation of syncytium formation by plasma membrane fusion namespace: biological_process def: "Any process that decreases the frequency, rate or extent of the formation of a syncytium, a mass of cytoplasm containing several nuclei enclosed within a single plasma membrane, by the fusion of the plasma membranes of two or more individual cells." [GOC:mah] is_a: GO:0051093 ! negative regulation of developmental process is_a: GO:0051129 ! negative regulation of cellular component organization is_a: GO:0060142 ! regulation of syncytium formation by plasma membrane fusion intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0000768 ! negatively regulates syncytium formation by plasma membrane fusion relationship: RO:0002212 GO:0000768 ! negatively regulates syncytium formation by plasma membrane fusion [Term] id: GO:0034248 name: regulation of amide metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving amides." [GOC:mah] synonym: "regulation of amide metabolism" EXACT [] synonym: "regulation of cellular amide metabolic process" EXACT [] is_a: GO:0019222 ! regulation of metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0043603 ! regulates amide metabolic process relationship: RO:0002211 GO:0043603 ! regulates amide metabolic process [Term] id: GO:0034249 name: negative regulation of amide metabolic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving amides." [GOC:mah] synonym: "negative regulation of amide metabolism" EXACT [] synonym: "negative regulation of cellular amide metabolic process" EXACT [] is_a: GO:0009892 ! negative regulation of metabolic process is_a: GO:0034248 ! regulation of amide metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0043603 ! negatively regulates amide metabolic process relationship: RO:0002212 GO:0043603 ! negatively regulates amide metabolic process [Term] id: GO:0034250 name: positive regulation of amide metabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving amides." [GOC:mah] synonym: "positive regulation of amide metabolism" EXACT [] synonym: "positive regulation of cellular amide metabolic process" EXACT [] is_a: GO:0009893 ! positive regulation of metabolic process is_a: GO:0034248 ! regulation of amide metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0043603 ! positively regulates amide metabolic process relationship: RO:0002213 GO:0043603 ! positively regulates amide metabolic process [Term] id: GO:0034251 name: regulation of amide catabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of amides." [GOC:mah] synonym: "regulation of amide breakdown" EXACT [] synonym: "regulation of amide catabolism" EXACT [] synonym: "regulation of amide degradation" EXACT [] synonym: "regulation of cellular amide catabolic process" EXACT [] is_a: GO:0009894 ! regulation of catabolic process is_a: GO:0034248 ! regulation of amide metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0043605 ! regulates amide catabolic process relationship: RO:0002211 GO:0043605 ! regulates amide catabolic process [Term] id: GO:0034252 name: negative regulation of amide catabolic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of amides." [GOC:mah] synonym: "negative regulation of amide breakdown" EXACT [] synonym: "negative regulation of amide catabolism" EXACT [] synonym: "negative regulation of amide degradation" RELATED [] synonym: "negative regulation of cellular amide catabolic process" EXACT [] is_a: GO:0009895 ! negative regulation of catabolic process is_a: GO:0034249 ! negative regulation of amide metabolic process is_a: GO:0034251 ! regulation of amide catabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0043605 ! negatively regulates amide catabolic process relationship: RO:0002212 GO:0043605 ! negatively regulates amide catabolic process [Term] id: GO:0034253 name: positive regulation of amide catabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of amides." [GOC:mah] synonym: "positive regulation of amide breakdown" EXACT [] synonym: "positive regulation of amide catabolism" EXACT [] synonym: "positive regulation of amide degradation" RELATED [] synonym: "positive regulation of cellular amide catabolic process" EXACT [] is_a: GO:0009896 ! positive regulation of catabolic process is_a: GO:0034250 ! positive regulation of amide metabolic process is_a: GO:0034251 ! regulation of amide catabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0043605 ! positively regulates amide catabolic process relationship: RO:0002213 GO:0043605 ! positively regulates amide catabolic process [Term] id: GO:0034284 name: response to monosaccharide namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a monosaccharide stimulus." [GOC:mah] synonym: "response to monosaccharide stimulus" EXACT [GOC:dos] is_a: GO:0009743 ! response to carbohydrate intersection_of: GO:0050896 ! response to stimulus intersection_of: RO:0004009 CHEBI:35381 ! has primary input relationship: RO:0004009 CHEBI:35381 ! has primary input [Term] id: GO:0034293 name: sexual sporulation namespace: biological_process def: "The formation of spores derived from the products of meiosis." [GOC:mah] synonym: "meiotic spore formation" EXACT [] synonym: "meiotic sporulation" EXACT [] synonym: "sexual spore formation" EXACT [] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0043934 ! sporulation intersection_of: GO:0043934 ! sporulation intersection_of: BFO:0000050 GO:0051321 ! part of meiotic cell cycle relationship: BFO:0000050 GO:0051321 ! part of meiotic cell cycle property_value: RO:0002161 NCBITaxon:33083 [Term] id: GO:0034295 name: basidiospore formation namespace: biological_process def: "The process in which spores form outside a specialized end cell known as a basidium. Basidia are characteristic of the basidiomycete fungi (phylum Basidiomycota), and give rise to spores that each contain a haploid nucleus that is the product of meiosis. The spores are usually attached to the basidium by short spikes called sterigmata (singular: sterigma). In most basidiomycetes there are four sterigmata (and four spores) to a basidium." [GOC:di, GOC:ds, GOC:mah, GOC:mcc, https://en.wikipedia.org/wiki/Basidiospore] comment: Note that basidiospores and basidia are separate biological structures. The basidium is the structure that bear the basidiospores, but the development of the basidium is a different process than the formation of the basidiospores themselves. For this reason, GO:0034295 basidiospore formation and GO:0075313 basidium development are different terms and are not linked. is_a: BFO:0000003 is_a: GO:0043935 ! sexual sporulation resulting in formation of a cellular spore intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 CL:0000615 ! results in formation of anatomical entity basidiospore relationship: RO:0002297 CL:0000615 ! results in formation of anatomical entity basidiospore [Term] id: GO:0034296 name: zygospore formation namespace: biological_process def: "The process in which zygospores are formed. Zygospores are characteristic of the zygomycete fungi (phylum Zygomycota) thick-walled and darkly colored, and usually heavily ornamented as well, with many spines or ridges. It is formed between two specialized organs called suspensors, which are themselves usually heavily ornamented, one from each mating partner. The zygospore forms between them and then breaks away." [GOC:ds, GOC:mah, PMID:21858438] is_a: BFO:0000003 is_a: GO:0043935 ! sexual sporulation resulting in formation of a cellular spore intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 CL:0000608 ! results in formation of anatomical entity zygospore relationship: RO:0002297 CL:0000608 ! results in formation of anatomical entity zygospore [Term] id: GO:0034306 name: regulation of sexual sporulation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of spore formation from the products of meiosis. An example of this is found in Saccharomyces cerevisiae." [GOC:mah] synonym: "MAPKKK cascade during sporulation" RELATED [] synonym: "regulation of meiotic spore formation" EXACT [] synonym: "regulation of meiotic sporulation" EXACT [] synonym: "regulation of sexual spore formation" EXACT [] is_a: GO:0043937 ! regulation of sporulation is_a: GO:0051445 ! regulation of meiotic cell cycle intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0034293 ! regulates sexual sporulation relationship: RO:0002162 NCBITaxon:4751 ! in taxon Fungi relationship: RO:0002211 GO:0034293 ! regulates sexual sporulation [Term] id: GO:0034307 name: regulation of ascospore formation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of ascospore formation. An example of this process is found in Saccharomyces cerevisiae." [GOC:mah] synonym: "MAPKKK cascade during sporulation" RELATED [] is_a: GO:0010564 ! regulation of cell cycle process is_a: GO:0043940 ! regulation of sexual sporulation resulting in formation of a cellular spore is_a: GO:0060284 ! regulation of cell development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0030437 ! regulates ascospore formation relationship: RO:0002211 GO:0030437 ! regulates ascospore formation [Term] id: GO:0034308 name: primary alcohol metabolic process namespace: biological_process def: "The chemical reactions and pathways involving primary alcohols. A primary alcohol is any alcohol in which a hydroxy group, -OH, is attached to a saturated carbon atom which has either three hydrogen atoms attached to it or only one other carbon atom and two hydrogen atoms attached to it." [GOC:mah] synonym: "monohydric alcohol metabolic process" EXACT [] synonym: "primary alcohol metabolism" EXACT [GOC:mah] is_a: GO:0006066 ! alcohol metabolic process intersection_of: GO:0008152 ! metabolic process intersection_of: RO:0004007 CHEBI:15734 ! has primary input or output relationship: RO:0004007 CHEBI:15734 ! has primary input or output [Term] id: GO:0034309 name: primary alcohol biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of primary alcohols. A primary alcohol is any alcohol in which a hydroxy group, -OH, is attached to a saturated carbon atom which has either three hydrogen atoms attached to it or only one other carbon atom and two hydrogen atoms attached to it." [GOC:mah] synonym: "monohydric alcohol biosynthetic process" EXACT [] synonym: "primary alcohol anabolism" EXACT [GOC:mah] synonym: "primary alcohol biosynthesis" EXACT [GOC:mah] synonym: "primary alcohol formation" EXACT [GOC:mah] synonym: "primary alcohol synthesis" EXACT [GOC:mah] is_a: GO:0034308 ! primary alcohol metabolic process is_a: GO:0046165 ! alcohol biosynthetic process intersection_of: GO:0009058 ! biosynthetic process intersection_of: RO:0004008 CHEBI:15734 ! has primary output relationship: RO:0004008 CHEBI:15734 ! has primary output [Term] id: GO:0034310 name: primary alcohol catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of primary alcohols. A primary alcohol is any alcohol in which a hydroxy group, -OH, is attached to a saturated carbon atom which has either three hydrogen atoms attached to it or only one other carbon atom and two hydrogen atoms attached to it." [GOC:mah] synonym: "monohydric alcohol catabolic process" EXACT [] synonym: "primary alcohol breakdown" EXACT [GOC:mah] synonym: "primary alcohol catabolism" EXACT [GOC:mah] synonym: "primary alcohol degradation" EXACT [GOC:mah] is_a: GO:0034308 ! primary alcohol metabolic process is_a: GO:0046164 ! alcohol catabolic process intersection_of: GO:0009056 ! catabolic process intersection_of: RO:0004009 CHEBI:15734 ! has primary input relationship: RO:0004009 CHEBI:15734 ! has primary input [Term] id: GO:0034329 name: cell junction assembly namespace: biological_process def: "A cellular process that results in the aggregation, arrangement and bonding together of a set of components to form a cell junction." [GOC:mah] xref: Reactome:R-HSA-446728 "Cell junction organization" is_a: GO:0022607 ! cellular component assembly is_a: GO:0034330 ! cell junction organization intersection_of: GO:0022607 ! cellular component assembly intersection_of: RO:0002588 GO:0030054 ! results in assembly of cell junction relationship: RO:0002588 GO:0030054 ! results in assembly of cell junction property_value: RO:0002161 NCBITaxon:4751 [Term] id: GO:0034330 name: cell junction organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a cell junction. A cell junction is a specialized region of connection between two cells or between a cell and the extracellular matrix." [GOC:dph, GOC:jl, GOC:mah] subset: goslim_chembl subset: goslim_generic synonym: "cell junction assembly and maintenance" EXACT [] synonym: "cell junction biogenesis" RELATED [] synonym: "cell junction organisation" EXACT [GOC:mah] is_a: GO:0016043 ! cellular component organization intersection_of: GO:0016043 ! cellular component organization intersection_of: RO:0002592 GO:0030054 ! results in organization of cell junction relationship: RO:0002592 GO:0030054 ! results in organization of cell junction [Term] id: GO:0034349 name: glial cell apoptotic process namespace: biological_process def: "Any apoptotic process in a glial cell, a non-neuronal cell of the nervous system." [CL:0000125, GOC:mtg_apoptosis, GOC:sart] synonym: "apoptosis of glia" EXACT [] synonym: "apoptosis of glial cells" EXACT [] synonym: "glia apoptosis" EXACT [] synonym: "glia programmed cell death by apoptosis" EXACT [] synonym: "glial cell apoptosis" NARROW [] synonym: "glial cell programmed cell death by apoptosis" EXACT [] synonym: "programmed cell death of glia by apoptosis" EXACT [] synonym: "programmed cell death of glial cells by apoptosis" EXACT [] synonym: "programmed cell death, glia" EXACT [] synonym: "programmed cell death, glial cells" EXACT [] is_a: GO:0006915 ! apoptotic process intersection_of: GO:0006915 ! apoptotic process intersection_of: BFO:0000066 CL:0000125 ! occurs in glial cell relationship: BFO:0000066 CL:0000125 ! occurs in glial cell property_value: RO:0002161 NCBITaxon:4896 [Term] id: GO:0034350 name: regulation of glial cell apoptotic process namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of glial cell apoptotic process." [GOC:mah, GOC:mtg_apoptosis] synonym: "regulation of glial cell apoptosis" RELATED [] is_a: GO:0042981 ! regulation of apoptotic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0034349 ! regulates glial cell apoptotic process relationship: RO:0002211 GO:0034349 ! regulates glial cell apoptotic process property_value: RO:0002161 NCBITaxon:4896 [Term] id: GO:0034351 name: negative regulation of glial cell apoptotic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of glial cell apoptotic process." [GOC:mah, GOC:mtg_apoptosis] synonym: "down regulation of glial cell apoptosis" EXACT [] synonym: "down-regulation of glial cell apoptosis" EXACT [] synonym: "downregulation of glial cell apoptosis" EXACT [] synonym: "inhibition of glial cell apoptosis" NARROW [] synonym: "negative regulation of glial cell apoptosis" NARROW [] is_a: GO:0034350 ! regulation of glial cell apoptotic process is_a: GO:0043066 ! negative regulation of apoptotic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0034349 ! negatively regulates glial cell apoptotic process relationship: RO:0002212 GO:0034349 ! negatively regulates glial cell apoptotic process property_value: RO:0002161 NCBITaxon:4896 [Term] id: GO:0034352 name: positive regulation of glial cell apoptotic process namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of glial cell apoptotic process." [GOC:mah, GOC:mtg_apoptosis] synonym: "activation of glial cell apoptosis" NARROW [] synonym: "positive regulation of glial cell apoptosis" NARROW [] synonym: "stimulation of glial cell apoptosis" NARROW [] synonym: "up regulation of glial cell apoptosis" EXACT [] synonym: "up-regulation of glial cell apoptosis" EXACT [] synonym: "upregulation of glial cell apoptosis" EXACT [] is_a: GO:0034350 ! regulation of glial cell apoptotic process is_a: GO:0043065 ! positive regulation of apoptotic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0034349 ! positively regulates glial cell apoptotic process relationship: RO:0002213 GO:0034349 ! positively regulates glial cell apoptotic process property_value: RO:0002161 NCBITaxon:4896 [Term] id: GO:0034390 name: smooth muscle cell apoptotic process namespace: biological_process def: "Any apoptotic process in a smooth muscle cell. Smooth muscle consists of non-striated, elongated, spindle-shaped cell found lining the digestive tract, uterus, and blood vessels." [CL:0000192, GOC:BHF, GOC:mah, GOC:mtg_apoptosis, GOC:rl] synonym: "apoptosis of smooth muscle cells" EXACT [] synonym: "programmed cell death of smooth muscle cells by apoptosis" EXACT [] synonym: "programmed cell death, smooth muscle cells" EXACT [] synonym: "SMC apoptosis" EXACT [] synonym: "smooth muscle cell apoptosis" NARROW [] synonym: "smooth muscle cell programmed cell death by apoptosis" EXACT [] is_a: GO:0010657 ! muscle cell apoptotic process intersection_of: GO:0006915 ! apoptotic process intersection_of: BFO:0000066 CL:0000192 ! occurs in smooth muscle cell relationship: BFO:0000066 CL:0000192 ! occurs in smooth muscle cell [Term] id: GO:0034391 name: regulation of smooth muscle cell apoptotic process namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of smooth muscle cell apoptotic process." [GOC:BHF, GOC:mtg_apoptosis, GOC:rl] synonym: "regulation of SMC apoptosis" EXACT [] synonym: "regulation of smooth muscle cell apoptosis" NARROW [] is_a: GO:0010660 ! regulation of muscle cell apoptotic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0034390 ! regulates smooth muscle cell apoptotic process relationship: RO:0002211 GO:0034390 ! regulates smooth muscle cell apoptotic process [Term] id: GO:0034392 name: negative regulation of smooth muscle cell apoptotic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of smooth muscle cell apoptotic process." [GOC:BHF, GOC:mtg_apoptosis, GOC:rl] synonym: "down regulation of smooth muscle cell apoptosis" EXACT [] synonym: "down-regulation of smooth muscle cell apoptosis" EXACT [] synonym: "downregulation of smooth muscle cell apoptosis" EXACT [] synonym: "inhibition of smooth muscle cell apoptosis" NARROW [] synonym: "negative regulation of SMC apoptosis" EXACT [] synonym: "negative regulation of smooth muscle cell apoptosis" NARROW [] is_a: GO:0010656 ! negative regulation of muscle cell apoptotic process is_a: GO:0034391 ! regulation of smooth muscle cell apoptotic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0034390 ! negatively regulates smooth muscle cell apoptotic process relationship: RO:0002212 GO:0034390 ! negatively regulates smooth muscle cell apoptotic process [Term] id: GO:0034393 name: positive regulation of smooth muscle cell apoptotic process namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of smooth muscle cell apoptotic process." [GOC:BHF, GOC:mtg_apoptosis, GOC:rl] synonym: "activation of smooth muscle cell apoptosis" NARROW [] synonym: "positive regulation of SMC apoptosis" EXACT [] synonym: "positive regulation of smooth muscle cell apoptosis" NARROW [] synonym: "stimulation of smooth muscle cell apoptosis" NARROW [] synonym: "up regulation of smooth muscle cell apoptosis" EXACT [] synonym: "up-regulation of smooth muscle cell apoptosis" EXACT [] synonym: "upregulation of smooth muscle cell apoptosis" EXACT [] is_a: GO:0010661 ! positive regulation of muscle cell apoptotic process is_a: GO:0034391 ! regulation of smooth muscle cell apoptotic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0034390 ! positively regulates smooth muscle cell apoptotic process relationship: RO:0002213 GO:0034390 ! positively regulates smooth muscle cell apoptotic process [Term] id: GO:0034436 name: glycoprotein transport namespace: biological_process def: "The directed movement of a glycoprotein, a protein that contains covalently bound glycose (i.e. monosaccharide) residues, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:BHF, GOC:mah, GOC:rl] is_a: GO:0015031 ! protein transport is_a: GO:1901264 ! carbohydrate derivative transport intersection_of: GO:0006810 ! transport intersection_of: RO:0004009 CHEBI:17089 ! has primary input relationship: RO:0004009 CHEBI:17089 ! has primary input [Term] id: GO:0034486 name: vacuolar transmembrane transport namespace: biological_process def: "The process in which a solute is transported from one side of the vacuolar membrane to the other." [GOC:mah] comment: Note that this term is not intended for use in annotating lateral movement within membranes. synonym: "vacuolar membrane transport" EXACT [] is_a: GO:0055085 ! transmembrane transport intersection_of: GO:0055085 ! transmembrane transport intersection_of: RO:0002344 GO:0005773 ! results in transport to from or in vacuole relationship: RO:0002344 GO:0005773 ! results in transport to from or in vacuole [Term] id: GO:0034487 name: vacuolar amino acid transmembrane transport namespace: biological_process def: "The process in which an amino acid is transported from one side of the vacuolar membrane to the other." [GOC:mah] comment: Note that this term is not intended for use in annotating lateral movement within membranes. synonym: "vacuolar amino acid membrane transport" EXACT [] is_a: GO:0003333 ! amino acid transmembrane transport intersection_of: GO:0006810 ! transport intersection_of: RO:0002342 GO:0005774 ! results in transport across vacuolar membrane intersection_of: RO:0004009 CHEBI:35238 ! has primary input relationship: RO:0002342 GO:0005774 ! results in transport across vacuolar membrane [Term] id: GO:0034488 name: basic amino acid transmembrane export from vacuole namespace: biological_process def: "The directed movement of basic amino acids out of the vacuole, across the vacuolar membrane." [GOC:mah] is_a: GO:0032974 ! amino acid transmembrane export from vacuole is_a: GO:0034487 ! vacuolar amino acid transmembrane transport is_a: GO:1990822 ! basic amino acid transmembrane transport intersection_of: GO:0015802 ! basic amino acid transport intersection_of: RO:0002338 GO:0005775 ! has target start location vacuolar lumen intersection_of: RO:0002339 GO:0005829 ! has target end location cytosol intersection_of: RO:0002342 GO:0005774 ! results in transport across vacuolar membrane [Term] id: GO:0034489 name: neutral amino acid transmembrane export from vacuole namespace: biological_process def: "The directed movement of neutral amino acids out of the vacuole, across the vacuolar membrane." [GOC:mah] is_a: GO:0015804 ! neutral amino acid transport is_a: GO:0032974 ! amino acid transmembrane export from vacuole intersection_of: GO:0015804 ! neutral amino acid transport intersection_of: RO:0002338 GO:0005775 ! has target start location vacuolar lumen intersection_of: RO:0002339 GO:0005829 ! has target end location cytosol intersection_of: RO:0002342 GO:0016020 ! results in transport across membrane intersection_of: RO:0004009 CHEBI:35238 ! has primary input [Term] id: GO:0034490 name: basic amino acid transmembrane import into vacuole namespace: biological_process def: "The directed movement of basic amino acids into the vacuole across the vacuolar membrane." [GOC:mah] is_a: GO:0032975 ! amino acid transmembrane import into vacuole is_a: GO:1990822 ! basic amino acid transmembrane transport intersection_of: GO:0015802 ! basic amino acid transport intersection_of: RO:0002338 GO:0005829 ! has target start location cytosol intersection_of: RO:0002339 GO:0005775 ! has target end location vacuolar lumen intersection_of: RO:0002342 GO:0016020 ! results in transport across membrane intersection_of: RO:0004009 CHEBI:35238 ! has primary input [Term] id: GO:0034491 name: neutral amino acid transmembrane import into vacuole namespace: biological_process def: "The directed movement of neutral amino acids into the vacuole across the vacuolar membrane." [GOC:mah] is_a: GO:0015804 ! neutral amino acid transport is_a: GO:0032975 ! amino acid transmembrane import into vacuole intersection_of: GO:0015804 ! neutral amino acid transport intersection_of: RO:0002338 GO:0005829 ! has target start location cytosol intersection_of: RO:0002339 GO:0005775 ! has target end location vacuolar lumen intersection_of: RO:0002342 GO:0016020 ! results in transport across membrane intersection_of: RO:0004009 CHEBI:35238 ! has primary input [Term] id: GO:0034502 name: protein localization to chromosome namespace: biological_process def: "Any process in which a protein is transported to, or maintained at, a specific location on a chromosome." [GOC:mah] synonym: "condensin localization to chromosome" NARROW [] synonym: "protein localisation to chromosome" EXACT [GOC:mah] is_a: GO:0033365 ! protein localization to organelle intersection_of: GO:0008104 ! intracellular protein localization intersection_of: RO:0002339 GO:0005694 ! has target end location chromosome relationship: RO:0002339 GO:0005694 ! has target end location chromosome [Term] id: GO:0034504 name: protein localization to nucleus namespace: biological_process def: "A process in which a protein transports or maintains the localization of another protein to the nucleus." [GOC:ecd] synonym: "protein localisation to nucleus" EXACT [GOC:mah] synonym: "protein localization in cell nucleus" EXACT [] synonym: "protein localization in nucleus" EXACT [GOC:mah] synonym: "protein targeting to nucleus" RELATED [] is_a: GO:0033365 ! protein localization to organelle intersection_of: GO:0008104 ! intracellular protein localization intersection_of: RO:0002339 GO:0005634 ! has target end location nucleus relationship: RO:0002339 GO:0005634 ! has target end location nucleus creation_date: 2012-11-07T15:45:54Z [Term] id: GO:0034505 name: tooth mineralization namespace: biological_process def: "The process in which calcium salts are deposited into calcareous tooth structures such as dental enamel, dentin and cementum." [GOC:mah, MP:0002817, MSH:D014074] synonym: "tooth calcification" EXACT [] is_a: GO:0031214 ! biomineral tissue development intersection_of: GO:0031214 ! biomineral tissue development intersection_of: RO:0002299 UBERON:0001091 ! results in maturation of calcareous tooth relationship: BFO:0000050 GO:0042476 ! part of odontogenesis relationship: RO:0002299 UBERON:0001091 ! results in maturation of calcareous tooth property_value: RO:0002161 NCBITaxon:8782 [Term] id: GO:0034599 name: cellular response to oxidative stress namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals." [GOC:mah] synonym: "adaptive response to oxidative stress" NARROW [GOC:add, GOC:vk] xref: Reactome:R-HSA-3299685 "Detoxification of Reactive Oxygen Species" xref: Reactome:R-HSA-9707564 "Cytoprotection by HMOX1" is_a: GO:0006979 ! response to oxidative stress is_a: GO:0062197 ! cellular response to chemical stress [Term] id: GO:0034614 name: cellular response to reactive oxygen species namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a reactive oxygen species stimulus. Reactive oxygen species include singlet oxygen, superoxide, and oxygen free radicals." [GOC:mah] synonym: "cellular response to active oxygen species" EXACT [] synonym: "cellular response to AOS" EXACT [] synonym: "cellular response to reactive oxidative species" EXACT [] synonym: "cellular response to reactive oxygen intermediate" EXACT [] synonym: "cellular response to ROI" EXACT [] synonym: "cellular response to ROS" EXACT [] is_a: GO:0000302 ! response to reactive oxygen species is_a: GO:0034599 ! cellular response to oxidative stress is_a: GO:1901701 ! cellular response to oxygen-containing compound intersection_of: GO:0070887 ! cellular response to chemical stimulus intersection_of: RO:0004009 CHEBI:26523 ! has primary input [Term] id: GO:0034642 name: mitochondrion migration along actin filament namespace: biological_process def: "The directed movement of a mitochondrion along a microfilament, mediated by motor proteins." [GOC:mah, PMID:15979253, PMID:16306220] synonym: "mitochondrial migration along actin filament" EXACT [GOC:dph, GOC:tb] synonym: "mitochondrial migration along microfilament" EXACT [] synonym: "mitochondrial migration, actin-mediated" EXACT [] synonym: "mitochondrion migration along microfilament" EXACT [] synonym: "mitochondrion transport along actin filament" EXACT [] is_a: GO:0030048 ! actin filament-based movement is_a: GO:0051654 ! establishment of mitochondrion localization is_a: GO:0099515 ! actin filament-based transport intersection_of: GO:0046907 ! intracellular transport intersection_of: RO:0002341 GO:0005884 ! results in transport along actin filament intersection_of: RO:0004009 GO:0005739 ! has primary input mitochondrion [Term] id: GO:0034643 name: establishment of mitochondrion localization, microtubule-mediated namespace: biological_process def: "The directed movement of the mitochondrion to a specific location, by a process involving microtubules." [GOC:mah, PMID:12972644, PMID:15979253, PMID:16306220] synonym: "establishment of mitochondrion localisation, microtubule-mediated" EXACT [GOC:mah] synonym: "microtubule-mediated mitochondrion localization" EXACT [] synonym: "mitochondrial localization, microtubule-mediated" EXACT [] is_a: GO:0007018 ! microtubule-based movement is_a: GO:0051654 ! establishment of mitochondrion localization intersection_of: GO:0051234 ! establishment of localization intersection_of: RO:0002608 GO:0005874 ! process has causal agent microtubule intersection_of: RO:0004009 GO:0005739 ! has primary input mitochondrion [Term] id: GO:0034654 name: nucleobase-containing compound biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:mah] synonym: "nucleobase, nucleoside, nucleotide and nucleic acid anabolism" EXACT [] synonym: "nucleobase, nucleoside, nucleotide and nucleic acid biosynthesis" EXACT [] synonym: "nucleobase, nucleoside, nucleotide and nucleic acid formation" EXACT [] synonym: "nucleobase, nucleoside, nucleotide and nucleic acid synthesis" NARROW [] is_a: GO:0006139 ! nucleobase-containing compound metabolic process is_a: GO:0009058 ! biosynthetic process intersection_of: GO:0009058 ! biosynthetic process intersection_of: RO:0004008 CHEBI:61120 ! has primary output relationship: RO:0004008 CHEBI:61120 ! has primary output [Term] id: GO:0034655 name: nucleobase-containing compound catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:mah] subset: goslim_chembl synonym: "nucleobase, nucleoside, nucleotide and nucleic acid breakdown" EXACT [] synonym: "nucleobase, nucleoside, nucleotide and nucleic acid catabolic process" RELATED [GOC:dph, GOC:tb] synonym: "nucleobase, nucleoside, nucleotide and nucleic acid catabolism" EXACT [] synonym: "nucleobase, nucleoside, nucleotide and nucleic acid degradation" EXACT [] is_a: GO:0006139 ! nucleobase-containing compound metabolic process is_a: GO:0009056 ! catabolic process intersection_of: GO:0009056 ! catabolic process intersection_of: RO:0004009 CHEBI:61120 ! has primary input relationship: RO:0004009 CHEBI:61120 ! has primary input [Term] id: GO:0034672 name: anterior/posterior pattern specification involved in pronephros development namespace: biological_process def: "The developmental process that results in the creation of defined areas or spaces within the pronephros along the anterior/posterior axis to which cells respond and eventually are instructed to differentiate." [GOC:mah] synonym: "anterior/posterior pattern specification involved in pronephric kidney development" EXACT [GOC:mtg_kidney_jan10] is_a: GO:0039017 ! pattern specification involved in pronephros development is_a: GO:0072098 ! anterior/posterior pattern specification involved in kidney development intersection_of: GO:0009952 ! anterior/posterior pattern specification intersection_of: BFO:0000050 GO:0048793 ! part of pronephros development [Term] id: GO:0034702 name: monoatomic ion channel complex namespace: cellular_component def: "A protein complex that spans a membrane and forms a water-filled channel across the phospholipid bilayer allowing selective monoatomic ion transport down its electrochemical gradient." [GOC:mah, ISBN:071673706X] is_a: GO:1902495 ! transmembrane transporter complex intersection_of: GO:0032991 ! protein-containing complex intersection_of: RO:0002215 GO:0005216 ! capable of monoatomic ion channel activity relationship: RO:0002215 GO:0005216 ! capable of monoatomic ion channel activity property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/20026" xsd:anyURI [Term] id: GO:0034703 name: cation channel complex namespace: cellular_component def: "An ion channel complex through which cations pass." [GOC:mah] is_a: GO:0034702 ! monoatomic ion channel complex intersection_of: GO:0032991 ! protein-containing complex intersection_of: RO:0002215 GO:0005261 ! capable of monoatomic cation channel activity relationship: RO:0002215 GO:0005261 ! capable of monoatomic cation channel activity [Term] id: GO:0034704 name: calcium channel complex namespace: cellular_component def: "An ion channel complex through which calcium ions pass." [GOC:mah] is_a: GO:0034703 ! cation channel complex intersection_of: GO:0032991 ! protein-containing complex intersection_of: RO:0002215 GO:0005262 ! capable of calcium channel activity relationship: RO:0002215 GO:0005262 ! capable of calcium channel activity [Term] id: GO:0034705 name: potassium channel complex namespace: cellular_component def: "An ion channel complex through which potassium ions pass." [GOC:mah] is_a: GO:0034703 ! cation channel complex intersection_of: GO:0032991 ! protein-containing complex intersection_of: RO:0002215 GO:0005267 ! capable of potassium channel activity relationship: RO:0002215 GO:0005267 ! capable of potassium channel activity [Term] id: GO:0034706 name: sodium channel complex namespace: cellular_component def: "An ion channel complex through which sodium ions pass." [GOC:mah] is_a: GO:0034703 ! cation channel complex intersection_of: GO:0032991 ! protein-containing complex intersection_of: RO:0002215 GO:0005272 ! capable of sodium channel activity relationship: RO:0002215 GO:0005272 ! capable of sodium channel activity [Term] id: GO:0034755 name: iron ion transmembrane transport namespace: biological_process def: "A process in which an iron ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:mah, PMID:11390404] comment: Note that this term is not intended for use in annotating lateral movement within membranes. synonym: "ferrous ion transmembrane transport" NARROW [] synonym: "ferrous iron transmembrane transport" NARROW [] synonym: "high affinity ferrous ion transmembrane transport" NARROW [] synonym: "high affinity iron ion transport" NARROW [] synonym: "high-affinity ferrous ion transmembrane transport" NARROW [] synonym: "high-affinity iron ion transmembrane transport" NARROW [] synonym: "high-affinity iron ion transport" NARROW [] synonym: "iron ion membrane transport" EXACT [] synonym: "iron(2+) transmembrane transport" NARROW [] synonym: "low affinity iron ion transport" NARROW [] synonym: "low-affinity iron ion transmembrane transport" NARROW [] synonym: "low-affinity iron ion transport" NARROW [] synonym: "transmembrane iron transport" EXACT [] is_a: GO:0006826 ! iron ion transport is_a: GO:0098655 ! monoatomic cation transmembrane transport intersection_of: GO:0006826 ! iron ion transport intersection_of: RO:0002342 GO:0016020 ! results in transport across membrane creation_date: 2015-02-06T11:29:22Z [Term] id: GO:0034756 name: regulation of iron ion transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the directed movement of iron ions (Fe) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah] synonym: "regulation of Fe transport" EXACT [] synonym: "regulation of iron import" NARROW [GOC:TermGenie] synonym: "regulation of iron ion import" NARROW [] synonym: "regulation of iron transport" EXACT [] is_a: GO:0010959 ! regulation of metal ion transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0006826 ! regulates iron ion transport relationship: RO:0002211 GO:0006826 ! regulates iron ion transport creation_date: 2012-04-18T04:00:14Z [Term] id: GO:0034757 name: negative regulation of iron ion transport namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of iron ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah] synonym: "down regulation of iron ion transport" EXACT [] synonym: "down-regulation of iron ion transport" EXACT [] synonym: "downregulation of iron ion transport" EXACT [] synonym: "inhibition of iron ion transport" NARROW [] synonym: "negative regulation of iron transport" EXACT [] is_a: GO:0034756 ! regulation of iron ion transport is_a: GO:0043271 ! negative regulation of monoatomic ion transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0006826 ! negatively regulates iron ion transport relationship: RO:0002212 GO:0006826 ! negatively regulates iron ion transport [Term] id: GO:0034758 name: positive regulation of iron ion transport namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the directed movement of iron ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah] synonym: "activation of iron ion transport" NARROW [] synonym: "positive regulation of iron transport" EXACT [] synonym: "stimulation of iron ion transport" NARROW [] synonym: "up regulation of iron ion transport" EXACT [] synonym: "up-regulation of iron ion transport" EXACT [] synonym: "upregulation of iron ion transport" EXACT [] is_a: GO:0034756 ! regulation of iron ion transport is_a: GO:0043270 ! positive regulation of monoatomic ion transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0006826 ! positively regulates iron ion transport relationship: RO:0002213 GO:0006826 ! positively regulates iron ion transport [Term] id: GO:0034759 name: regulation of iron ion transmembrane transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the directed movement of iron ions (Fe) from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:mah] synonym: "regulation of iron ion membrane transport" EXACT [] synonym: "regulation of transmembrane Fe transport" EXACT [] synonym: "regulation of transmembrane iron ion transport" EXACT [GOC:dph, GOC:tb] synonym: "regulation of transmembrane iron transport" EXACT [] is_a: GO:0034756 ! regulation of iron ion transport is_a: GO:1904062 ! regulation of monoatomic cation transmembrane transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0034755 ! regulates iron ion transmembrane transport relationship: RO:0002211 GO:0034755 ! regulates iron ion transmembrane transport [Term] id: GO:0034760 name: negative regulation of iron ion transmembrane transport namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of iron ions from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:mah] synonym: "down regulation of transmembrane iron ion transport" EXACT [] synonym: "down-regulation of transmembrane iron ion transport" EXACT [] synonym: "downregulation of transmembrane iron ion transport" EXACT [] synonym: "inhibition of transmembrane iron ion transport" NARROW [] synonym: "negative regulation of iron ion membrane transport" EXACT [] synonym: "negative regulation of transmembrane iron ion transport" EXACT [GOC:dph, GOC:tb] synonym: "negative regulation of transmembrane iron transport" EXACT [] is_a: GO:0034757 ! negative regulation of iron ion transport is_a: GO:0034759 ! regulation of iron ion transmembrane transport is_a: GO:1904063 ! negative regulation of cation transmembrane transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0034755 ! negatively regulates iron ion transmembrane transport relationship: RO:0002212 GO:0034755 ! negatively regulates iron ion transmembrane transport [Term] id: GO:0034761 name: positive regulation of iron ion transmembrane transport namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the directed movement of iron ions from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:mah] synonym: "activation of transmembrane iron ion transport" NARROW [] synonym: "positive regulation of iron ion membrane transport" EXACT [] synonym: "positive regulation of transmembrane iron ion transport" EXACT [GOC:dph, GOC:tb] synonym: "positive regulation of transmembrane iron transport" EXACT [] synonym: "stimulation of transmembrane iron ion transport" NARROW [] synonym: "up regulation of transmembrane iron ion transport" EXACT [] synonym: "up-regulation of transmembrane iron ion transport" EXACT [] synonym: "upregulation of transmembrane iron ion transport" EXACT [] is_a: GO:0034758 ! positive regulation of iron ion transport is_a: GO:0034759 ! regulation of iron ion transmembrane transport is_a: GO:1904064 ! positive regulation of cation transmembrane transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0034755 ! positively regulates iron ion transmembrane transport relationship: RO:0002213 GO:0034755 ! positively regulates iron ion transmembrane transport [Term] id: GO:0034762 name: regulation of transmembrane transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the directed movement of a solute from one side of a membrane to the other." [GOC:mah] synonym: "regulation of membrane transport" EXACT [] is_a: GO:0050794 ! regulation of cellular process is_a: GO:0051049 ! regulation of transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0055085 ! regulates transmembrane transport relationship: RO:0002211 GO:0055085 ! regulates transmembrane transport [Term] id: GO:0034763 name: negative regulation of transmembrane transport namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of a solute from one side of a membrane to the other." [GOC:mah] synonym: "down regulation of transmembrane transport" EXACT [] synonym: "down-regulation of transmembrane transport" EXACT [] synonym: "downregulation of transmembrane transport" EXACT [] synonym: "inhibition of transmembrane transport" NARROW [] synonym: "negative regulation of membrane transport" EXACT [] is_a: GO:0034762 ! regulation of transmembrane transport is_a: GO:0048523 ! negative regulation of cellular process is_a: GO:0051051 ! negative regulation of transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0055085 ! negatively regulates transmembrane transport relationship: RO:0002212 GO:0055085 ! negatively regulates transmembrane transport [Term] id: GO:0034764 name: positive regulation of transmembrane transport namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the directed movement of a solute from one side of a membrane to the other." [GOC:mah] synonym: "activation of transmembrane transport" NARROW [] synonym: "positive regulation of membrane transport" EXACT [] synonym: "stimulation of transmembrane transport" NARROW [] synonym: "up regulation of transmembrane transport" EXACT [] synonym: "up-regulation of transmembrane transport" EXACT [] synonym: "upregulation of transmembrane transport" EXACT [] is_a: GO:0034762 ! regulation of transmembrane transport is_a: GO:0048522 ! positive regulation of cellular process is_a: GO:0051050 ! positive regulation of transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0055085 ! positively regulates transmembrane transport relationship: RO:0002213 GO:0055085 ! positively regulates transmembrane transport [Term] id: GO:0034765 name: regulation of monoatomic ion transmembrane transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the directed movement of ions from one side of a membrane to the other." [GOC:mah] synonym: "regulation of ion membrane transport" EXACT [] synonym: "regulation of ion transmembrane transport" BROAD [] synonym: "regulation of transmembrane ion transport" EXACT [GOC:dph, GOC:tb] is_a: GO:0034762 ! regulation of transmembrane transport is_a: GO:0043269 ! regulation of monoatomic ion transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0034220 ! regulates monoatomic ion transmembrane transport relationship: RO:0002211 GO:0034220 ! regulates monoatomic ion transmembrane transport [Term] id: GO:0034766 name: negative regulation of monoatomic ion transmembrane transport namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of ions from one side of a membrane to the other." [GOC:mah] synonym: "down regulation of transmembrane ion transport" EXACT [] synonym: "down-regulation of transmembrane ion transport" EXACT [] synonym: "downregulation of transmembrane ion transport" EXACT [] synonym: "inhibition of transmembrane ion transport" NARROW [] synonym: "negative regulation of ion membrane transport" EXACT [] synonym: "negative regulation of ion transmembrane transport" BROAD [] synonym: "negative regulation of transmembrane ion transport" EXACT [GOC:dph, GOC:tb] is_a: GO:0034763 ! negative regulation of transmembrane transport is_a: GO:0034765 ! regulation of monoatomic ion transmembrane transport is_a: GO:0043271 ! negative regulation of monoatomic ion transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0034220 ! negatively regulates monoatomic ion transmembrane transport relationship: RO:0002212 GO:0034220 ! negatively regulates monoatomic ion transmembrane transport [Term] id: GO:0034767 name: positive regulation of monoatomic ion transmembrane transport namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the directed movement of ions from one side of a membrane to the other." [GOC:mah] synonym: "activation of transmembrane ion transport" NARROW [] synonym: "positive regulation of ion membrane transport" EXACT [] synonym: "positive regulation of ion transmembrane transport" BROAD [] synonym: "positive regulation of transmembrane ion transport" EXACT [] synonym: "stimulation of transmembrane ion transport" NARROW [] synonym: "up regulation of transmembrane ion transport" EXACT [] synonym: "up-regulation of transmembrane ion transport" EXACT [] synonym: "upregulation of transmembrane ion transport" EXACT [] is_a: GO:0034764 ! positive regulation of transmembrane transport is_a: GO:0034765 ! regulation of monoatomic ion transmembrane transport is_a: GO:0043270 ! positive regulation of monoatomic ion transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0034220 ! positively regulates monoatomic ion transmembrane transport relationship: RO:0002213 GO:0034220 ! positively regulates monoatomic ion transmembrane transport [Term] id: GO:0034769 name: basement membrane disassembly namespace: biological_process def: "The controlled breakdown of the basement membrane in the context of a normal process such as imaginal disc eversion." [GOC:sart, PMID:17301221] comment: Note that this term has no relationship to 'membrane disassembly ; GO:0030397' because the basement membrane is not a lipid bilayer. synonym: "basal lamina disassembly" RELATED [] is_a: GO:0022617 ! extracellular matrix disassembly is_a: GO:0071711 ! basement membrane organization intersection_of: GO:0022411 ! cellular component disassembly intersection_of: RO:0002590 GO:0005604 ! results in disassembly of basement membrane relationship: RO:0002590 GO:0005604 ! results in disassembly of basement membrane creation_date: 2009-08-13T11:27:24Z [Term] id: GO:0034776 name: response to histamine namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a histamine stimulus. Histamine, the biogenic amine 2-(1H-imidazol-4-yl)ethanamine, is involved in local immune responses as well as regulating physiological function in the gut and acting as a neurotransmitter." [GOC:BHF, GOC:mah, GOC:vk] synonym: "response to histamine stimulus" EXACT [] is_a: GO:1901698 ! response to nitrogen compound intersection_of: GO:0050896 ! response to stimulus intersection_of: RO:0004009 CHEBI:58432 ! has primary input relationship: RO:0004009 CHEBI:58432 ! has primary input [Term] id: GO:0034982 name: mitochondrial protein processing namespace: biological_process def: "The peptide cleavage of mitochondrial proteins, including cleavage contributing to their import." [GOC:curators] synonym: "mitochondrial protein modification" RELATED [] is_a: GO:0016485 ! protein processing intersection_of: GO:0016485 ! protein processing intersection_of: BFO:0000066 GO:0005739 ! occurs in mitochondrion relationship: BFO:0000066 GO:0005739 ! occurs in mitochondrion relationship: RO:0002162 NCBITaxon:2759 ! in taxon Eukaryota [Term] id: GO:0035010 name: encapsulation of foreign target namespace: biological_process def: "Events resulting in the formation of a multilayered cellular sheath surrounding an invader and thus preventing its development. This defense mechanism is often seen in insects in response to nematodes or parasitoids, which are too large to be phagocytosed by individual hemocytes. In some organisms the capsule is blackened due to melanization." [GO_REF:0000022, GOC:bf, PMID:11846478, PMID:12225920] is_a: GO:0002252 ! immune effector process property_value: RO:0002161 NCBITaxon:4895 [Term] id: GO:0035019 name: somatic stem cell population maintenance namespace: biological_process def: "Any process by which an organism retains a population of somatic stem cells, undifferentiated cells in the embryo or adult which can undergo unlimited division and give rise to cell types of the body other than those of the germ-line." [GOC:bf, ISBN:0582227089] xref: Reactome:R-HSA-452723 "Transcriptional regulation of pluripotent stem cells" is_a: GO:0019827 ! stem cell population maintenance intersection_of: GO:0098727 ! maintenance of cell number intersection_of: RO:0012003 CL:0000723 ! acts on population of somatic stem cell relationship: RO:0012003 CL:0000723 ! acts on population of somatic stem cell property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0035026 name: leading edge cell differentiation namespace: biological_process def: "The process in which relatively unspecialized cells acquire specialized structural and/or functional features of leading edge cells, cells at the front of a migrating epithelial sheet." [GOC:bf] is_a: GO:0030855 ! epithelial cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000730 ! results in acquisition of features of leading edge cell relationship: RO:0002315 CL:0000730 ! results in acquisition of features of leading edge cell [Term] id: GO:0035039 name: male pronucleus assembly namespace: biological_process def: "The conversion at fertilization of the inactive sperm nucleus into a male pronucleus with its chromosomes processed for the first zygotic division." [GOC:bf, PMID:11735001] synonym: "male pronucleus formation" RELATED [GOC:dph] is_a: GO:0006997 ! nucleus organization is_a: GO:0070925 ! organelle assembly intersection_of: GO:0022607 ! cellular component assembly intersection_of: RO:0002588 GO:0001940 ! results in assembly of male pronucleus relationship: BFO:0000050 GO:0007338 ! part of single fertilization relationship: RO:0002588 GO:0001940 ! results in assembly of male pronucleus [Term] id: GO:0035040 name: sperm nuclear envelope removal namespace: biological_process def: "Removal of the sperm nuclear envelope, allowing entry of maternal factors into the sperm nucleus." [GOC:bf, PMID:11735001] is_a: GO:0051081 ! nuclear membrane disassembly intersection_of: GO:0051081 ! nuclear membrane disassembly intersection_of: BFO:0000066 CL:0000019 ! occurs in sperm relationship: BFO:0000050 GO:0035039 ! part of male pronucleus assembly relationship: BFO:0000066 CL:0000019 ! occurs in sperm [Term] id: GO:0035045 name: sperm plasma membrane disassembly namespace: biological_process def: "The gradual disintegration of the sperm plasma membrane following insemination. This process is seen in Drosophila after entry of the entire sperm, surrounded by its plasma membrane, into the egg." [GOC:bf, ISBN:0879694238] synonym: "sperm plasma membrane breakdown" EXACT [] synonym: "sperm plasma membrane catabolism" EXACT [] synonym: "sperm plasma membrane degradation" EXACT [] is_a: GO:0007009 ! plasma membrane organization is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism is_a: GO:0030397 ! membrane disassembly intersection_of: GO:0022411 ! cellular component disassembly intersection_of: RO:0002590 GO:0097524 ! results in disassembly of sperm plasma membrane relationship: BFO:0000050 GO:0007338 ! part of single fertilization relationship: RO:0002590 GO:0097524 ! results in disassembly of sperm plasma membrane property_value: RO:0002161 NCBITaxon:58024 [Term] id: GO:0035050 name: embryonic heart tube development namespace: biological_process def: "The process whose specific outcome is the progression of the embryonic heart tube over time, from its formation to the mature structure. The heart tube forms as the heart rudiment from the heart field." [GOC:go_curators] is_a: GO:0035295 ! tube development is_a: GO:0060429 ! epithelium development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0004141 ! results in development of heart tube relationship: BFO:0000050 GO:0007507 ! part of heart development relationship: BFO:0000050 GO:0048568 ! part of embryonic organ development relationship: RO:0002296 UBERON:0004141 ! results in development of heart tube [Term] id: GO:0035051 name: cardiocyte differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of a cell that will form part of the cardiac organ of an individual." [GOC:bf] synonym: "cardiac cell differentiation" EXACT [] synonym: "heart cell differentiation" EXACT [] is_a: GO:0030154 ! cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0002494 ! results in acquisition of features of cardiocyte relationship: BFO:0000050 GO:0007507 ! part of heart development relationship: RO:0002315 CL:0002494 ! results in acquisition of features of cardiocyte [Term] id: GO:0035082 name: axoneme assembly namespace: biological_process def: "The assembly and organization of an axoneme, the bundle of microtubules and associated proteins that forms the core of cilia (also called flagella) in eukaryotic cells and is responsible for their movements." [GOC:bf, GOC:cilia, GOC:jl, ISBN:0815316194] comment: Note that cilia and eukaryotic flagella are deemed to be equivalent. synonym: "axoneme biogenesis" RELATED [GOC:mah] synonym: "ciliary axoneme assembly" EXACT [] synonym: "cilium axoneme assembly" EXACT [] synonym: "cilium axoneme biogenesis" RELATED [GOC:mah] synonym: "flagellar axoneme assembly" EXACT [] synonym: "flagellum axoneme assembly" EXACT [] is_a: GO:0001578 ! microtubule bundle formation is_a: GO:0022607 ! cellular component assembly intersection_of: GO:0022607 ! cellular component assembly intersection_of: RO:0002588 GO:0005930 ! results in assembly of axoneme relationship: BFO:0000050 GO:0060271 ! part of cilium assembly relationship: RO:0002588 GO:0005930 ! results in assembly of axoneme property_value: RO:0002161 NCBITaxon:3176 property_value: RO:0002161 NCBITaxon:3378 property_value: RO:0002161 NCBITaxon:3398 property_value: RO:0002161 NCBITaxon:4890 property_value: RO:0002161 NCBITaxon:5782 [Term] id: GO:0035099 name: hemocyte migration namespace: biological_process def: "The directed movement of a hemocyte within the embryo. Hemocytes are blood cells associated with a hemocoel (the cavity containing most of the major organs of the arthropod body) which are involved in defense and clotting of hemolymph, but not involved in transport of oxygen. In Drosophila, embryonic hemocytes originate from the head mesoderm as a cluster of cells. The cluster splits into two and one group of cells crosses the amnioserosa. Both populations then spread toward the middle of the embryo and then disperse evenly throughout the embryo." [GOC:bf, GOC:mtg_sensu, PMID:12885551] synonym: "arthropod blood cell migration" EXACT [] synonym: "hemocyte cell migration" EXACT [] is_a: BFO:0000003 is_a: GO:0016477 ! cell migration intersection_of: GO:0016477 ! cell migration intersection_of: RO:0002565 CL:0000387 ! results in movement of hemocyte (sensu Arthropoda) relationship: BFO:0000050 GO:0035162 ! part of embryonic hemopoiesis relationship: RO:0002162 NCBITaxon:6656 ! in taxon Arthropoda relationship: RO:0002565 CL:0000387 ! results in movement of hemocyte (sensu Arthropoda) [Term] id: GO:0035107 name: appendage morphogenesis namespace: biological_process def: "The process in which the anatomical structures of appendages are generated and organized. An appendage is an organ or part that is attached to the trunk of an organism, such as a limb or a branch." [ISBN:0582227089] is_a: BFO:0000003 is_a: GO:0009653 ! anatomical structure morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0000026 ! results in morphogenesis of appendage relationship: BFO:0000050 GO:0048736 ! part of appendage development relationship: RO:0002298 UBERON:0000026 ! results in morphogenesis of appendage [Term] id: GO:0035108 name: limb morphogenesis namespace: biological_process def: "The process in which the anatomical structures of a limb are generated and organized. A limb is a paired appendage of a tetrapod used for locomotion or grasping." [UBERON:0002101] synonym: "limb bud morphogenesis" NARROW [GOC:dph] is_a: GO:0035107 ! appendage morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0002101 ! results in morphogenesis of limb relationship: BFO:0000050 GO:0060173 ! part of limb development relationship: RO:0002162 NCBITaxon:32523 ! in taxon Tetrapoda relationship: RO:0002298 UBERON:0002101 ! results in morphogenesis of limb [Term] id: GO:0035112 name: genitalia morphogenesis namespace: biological_process def: "The process in which the anatomical structures of genitalia are generated and organized. The genitalia are the organs of reproduction or generation, external and internal." [GOC:bf] synonym: "genital morphogenesis" RELATED [] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0009887 ! animal organ morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0000990 ! results in morphogenesis of reproductive system relationship: BFO:0000050 GO:0048806 ! part of genitalia development relationship: RO:0002298 UBERON:0000990 ! results in morphogenesis of reproductive system [Term] id: GO:0035136 name: forelimb morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the forelimb are generated and organized. The forelimbs are the front limbs of an animal, e.g. the arms of a human." [GOC:go_curators] synonym: "arm morphogenesis" NARROW [GOC:bf, GOC:cjm] is_a: GO:0035108 ! limb morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0002102 ! results in morphogenesis of forelimb relationship: RO:0002298 UBERON:0002102 ! results in morphogenesis of forelimb [Term] id: GO:0035137 name: hindlimb morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the hindlimb are generated and organized." [GOC:go_curators] is_a: GO:0035108 ! limb morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0002103 ! results in morphogenesis of hindlimb relationship: RO:0002298 UBERON:0002103 ! results in morphogenesis of hindlimb [Term] id: GO:0035148 name: tube formation namespace: biological_process def: "Creation of the central hole of a tube in an anatomical structure through which gases and/or liquids flow." [GOC:bf] synonym: "lumen formation in an anatomical structure" RELATED [GOC:dph, GOC:mah] synonym: "tube lumen formation" EXACT [GOC:dph, GOC:mah] is_a: BFO:0000003 is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0000025 ! results in formation of anatomical entity tube relationship: BFO:0000050 GO:0035239 ! part of tube morphogenesis relationship: RO:0002297 UBERON:0000025 ! results in formation of anatomical entity tube [Term] id: GO:0035162 name: embryonic hemopoiesis namespace: biological_process def: "The stages of blood cell formation that take place within the embryo." [GOC:bf] synonym: "embryonic haematopoiesis" EXACT [] synonym: "embryonic haemopoiesis" EXACT [] synonym: "embryonic hematopoiesis" EXACT [] is_a: GO:0030097 ! hemopoiesis is_a: GO:0048568 ! embryonic organ development [Term] id: GO:0035163 name: embryonic hemocyte differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell derived from the embryonic head mesoderm acquires the specialized features of a mature hemocyte. Hemocytes are blood cells associated with a hemocoel (the cavity containing most of the major organs of the arthropod body) which are involved in defense and clotting of hemolymph, but not involved in transport of oxygen." [GOC:bf, GOC:mtg_sensu, PMID:14602069] synonym: "embryonic arthropod blood cell differentiation" EXACT [] synonym: "embryonic hemocyte cell differentiation" EXACT [] is_a: GO:0042386 ! hemocyte differentiation relationship: BFO:0000050 GO:0035162 ! part of embryonic hemopoiesis [Term] id: GO:0035165 name: embryonic crystal cell differentiation namespace: biological_process def: "The process in which an embryonic mesoderm-derived hemocyte precursor cell acquires the specialized features of a crystal cell. Crystal cells are a class of cells that contain crystalline inclusions and are involved in the melanization of pathogenic material in the hemolymph." [GOC:bf, http://sdb.bio.purdue.edu/fly/gene/serpent3.htm] is_a: GO:0035163 ! embryonic hemocyte differentiation is_a: GO:0042688 ! crystal cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000715 ! results in acquisition of features of embryonic crystal cell relationship: RO:0002315 CL:0000715 ! results in acquisition of features of embryonic crystal cell [Term] id: GO:0035166 name: post-embryonic hemopoiesis namespace: biological_process def: "The stages of blood cell formation that take place after completion of embryonic development." [GOC:bf] synonym: "post-embryonic haemopoiesis" EXACT [] is_a: GO:0030097 ! hemopoiesis relationship: BFO:0000050 GO:0009791 ! part of post-embryonic development [Term] id: GO:0035167 name: larval lymph gland hemopoiesis namespace: biological_process def: "The production of blood cells from the larval lymph gland. The lymph gland consists of three to six bilaterally paired lobes that are attached to the cardioblasts during larval stages, and it degenerates during pupal stages." [GOC:bf, GOC:mtg_sensu, PMID:12445385] synonym: "larval lymph gland haematopoiesis" EXACT [] synonym: "larval lymph gland haemopoiesis" EXACT [] synonym: "larval lymph gland hematopoiesis" EXACT [] is_a: GO:0035166 ! post-embryonic hemopoiesis relationship: BFO:0000050 GO:0002164 ! part of larval development relationship: BFO:0000050 GO:0048542 ! part of lymph gland development [Term] id: GO:0035168 name: larval lymph gland hemocyte differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell derived from the larval lymph gland acquires the specialized features of a mature hemocyte. The lymph gland consists of three to six bilaterally paired lobes that are attached to the cardioblasts during larval stages, and it degenerates during pupal stages. Hemocytes are blood cells associated with a hemocoel (the cavity containing most of the major organs of the arthropod body) which are involved in defense and clotting of hemolymph, but not involved in transport of oxygen. An example of this process is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu, PMID:14602069] synonym: "larval lymph gland arthropod blood cell differentiation" EXACT [] is_a: GO:0042386 ! hemocyte differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000735 ! results in acquisition of features of lymph gland hemocyte relationship: BFO:0000050 GO:0035167 ! part of larval lymph gland hemopoiesis relationship: RO:0002315 CL:0000735 ! results in acquisition of features of lymph gland hemocyte [Term] id: GO:0035169 name: lymph gland plasmatocyte differentiation namespace: biological_process def: "The process in which a relatively unspecialized larval lymph gland-derived hemocyte precursor cell acquires the specialized features of the phagocytic blood-cell type, the plasmatocyte." [GOC:bf, PMID:11921077, PMID:8174791] synonym: "lymph gland plasmatocyte cell differentiation" EXACT [] is_a: GO:0035168 ! larval lymph gland hemocyte differentiation is_a: GO:0042387 ! plasmatocyte differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000733 ! results in acquisition of features of lymph gland plasmatocyte relationship: RO:0002315 CL:0000733 ! results in acquisition of features of lymph gland plasmatocyte [Term] id: GO:0035170 name: lymph gland crystal cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized larval lymph gland-derived hemocyte precursor cell acquires the specialized features of a crystal cell. Crystal cells are a class of cells that contain crystalline inclusions and are involved in the melanization of pathogenic material in the hemolymph." [GOC:bf, http://sdb.bio.purdue.edu/fly/gene/serpent3.htm] is_a: GO:0035168 ! larval lymph gland hemocyte differentiation is_a: GO:0042688 ! crystal cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000716 ! results in acquisition of features of lymph gland crystal cell relationship: RO:0002315 CL:0000716 ! results in acquisition of features of lymph gland crystal cell [Term] id: GO:0035171 name: lamellocyte differentiation namespace: biological_process def: "The process in which a relatively unspecialized hemocyte precursor cell acquires the specialized features of a lamellocyte. Lamellocytes are a hemocyte lineage that exists only in larvae, but are seldom observed in healthy animals. Lamellocytes differentiate massively in the lymph glands after parasitization and are large flat cells devoted to encapsulation of invaders too large to be phagocytosed by plasmatocytes." [GOC:bf, PMID:14734104] synonym: "lamellocyte cell differentiation" EXACT [] is_a: GO:0035168 ! larval lymph gland hemocyte differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000396 ! results in acquisition of features of lamellocyte relationship: RO:0002315 CL:0000396 ! results in acquisition of features of lamellocyte [Term] id: GO:0035172 name: hemocyte proliferation namespace: biological_process def: "The multiplication or reproduction of hemocytes, resulting in the expansion of the cell population. Hemocytes are blood cells associated with a hemocoel (the cavity containing most of the major organs of the arthropod body) which are involved in defense and clotting of hemolymph, but not involved in transport of oxygen." [GOC:bf, GOC:mtg_sensu] synonym: "arthropod blood cell proliferation" EXACT [] is_a: BFO:0000003 is_a: GO:0002376 ! immune system process is_a: GO:0008283 ! cell population proliferation intersection_of: GO:0008283 ! cell population proliferation intersection_of: RO:0012003 CL:0000387 ! acts on population of hemocyte (sensu Arthropoda) relationship: RO:0002162 NCBITaxon:6656 ! in taxon Arthropoda relationship: RO:0012003 CL:0000387 ! acts on population of hemocyte (sensu Arthropoda) [Term] id: GO:0035190 name: syncytial nuclear migration namespace: biological_process def: "The directed movement of nuclei within the syncytial embryo of insects. These precise temporal and spatial patterns of nuclear movement are coordinated with mitotic divisions and are required during blastoderm formation to reposition dividing nuclei from the interior of the syncytial embryo to the cortex." [GOC:bf, ISBN:0879694238, PMID:8314839] is_a: GO:0007097 ! nuclear migration intersection_of: GO:0007097 ! nuclear migration intersection_of: BFO:0000066 CL:0000228 ! occurs in multinucleate cell relationship: BFO:0000050 GO:0001700 ! part of embryonic development via the syncytial blastoderm relationship: BFO:0000066 CL:0000228 ! occurs in multinucleate cell [Term] id: GO:0035203 name: regulation of lamellocyte differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of lamellocyte differentiation. Lamellocytes differentiate massively in the lymph glands after parasitization and are large flat cells devoted to encapsulation of invaders too large to be phagocytosed by plasmatocytes." [PMID:14734104] is_a: GO:0045610 ! regulation of hemocyte differentiation is_a: GO:1903706 ! regulation of hemopoiesis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0035171 ! regulates lamellocyte differentiation relationship: RO:0002211 GO:0035171 ! regulates lamellocyte differentiation [Term] id: GO:0035204 name: negative regulation of lamellocyte differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of lamellocyte differentiation. Lamellocytes differentiate massively in the lymph glands after parasitization and are large flat cells devoted to encapsulation of invaders too large to be phagocytosed by plasmatocytes." [PMID:14734104] synonym: "down regulation of lamellocyte differentiation" EXACT [] synonym: "down-regulation of lamellocyte differentiation" EXACT [] synonym: "downregulation of lamellocyte differentiation" EXACT [] synonym: "inhibition of lamellocyte differentiation" NARROW [] is_a: GO:0035203 ! regulation of lamellocyte differentiation is_a: GO:0045611 ! negative regulation of hemocyte differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0035171 ! negatively regulates lamellocyte differentiation relationship: RO:0002212 GO:0035171 ! negatively regulates lamellocyte differentiation [Term] id: GO:0035205 name: positive regulation of lamellocyte differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of lamellocyte differentiation. Lamellocytes differentiate massively in the lymph glands after parasitization and are large flat cells devoted to encapsulation of invaders too large to be phagocytosed by plasmatocytes." [PMID:14734104] synonym: "activation of lamellocyte differentiation" NARROW [] synonym: "stimulation of lamellocyte differentiation" NARROW [] synonym: "up regulation of lamellocyte differentiation" EXACT [] synonym: "up-regulation of lamellocyte differentiation" EXACT [] synonym: "upregulation of lamellocyte differentiation" EXACT [] is_a: GO:0035203 ! regulation of lamellocyte differentiation is_a: GO:0045612 ! positive regulation of hemocyte differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0035171 ! positively regulates lamellocyte differentiation relationship: RO:0002213 GO:0035171 ! positively regulates lamellocyte differentiation [Term] id: GO:0035206 name: regulation of hemocyte proliferation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of hemocyte proliferation. Hemocytes are blood cells associated with a hemocoel (the cavity containing most of the major organs of the arthropod body) which are involved in defense and clotting of hemolymph, but not involved in transport of oxygen. An example of this is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu] synonym: "regulation of arthropod blood cell proliferation" EXACT [] is_a: GO:0002682 ! regulation of immune system process is_a: GO:0042127 ! regulation of cell population proliferation is_a: GO:0050793 ! regulation of developmental process is_a: GO:0051239 ! regulation of multicellular organismal process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0035172 ! regulates hemocyte proliferation relationship: RO:0002211 GO:0035172 ! regulates hemocyte proliferation [Term] id: GO:0035207 name: negative regulation of hemocyte proliferation namespace: biological_process def: "Any process that stops, prevents or reduces the rate or extent of hemocyte proliferation. Hemocytes are blood cells associated with a hemocoel (the cavity containing most of the major organs of the arthropod body) which are involved in defense and clotting of hemolymph, but not involved in transport of oxygen. An example of this is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu] synonym: "down regulation of hemocyte proliferation" EXACT [] synonym: "down-regulation of hemocyte proliferation" EXACT [] synonym: "downregulation of hemocyte proliferation" EXACT [] synonym: "inhibition of hemocyte proliferation" NARROW [] synonym: "negative regulation of arthropod blood cell proliferation" EXACT [] is_a: GO:0002683 ! negative regulation of immune system process is_a: GO:0008285 ! negative regulation of cell population proliferation is_a: GO:0035206 ! regulation of hemocyte proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0035172 ! negatively regulates hemocyte proliferation relationship: RO:0002212 GO:0035172 ! negatively regulates hemocyte proliferation [Term] id: GO:0035208 name: positive regulation of hemocyte proliferation namespace: biological_process def: "Any process that activates or increases the rate or extent of hemocyte proliferation. Hemocytes are blood cells associated with a hemocoel (the cavity containing most of the major organs of the arthropod body) that are involved in defense and clotting of hemolymph, but not involved in transport of oxygen. An example of this process is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu] synonym: "activation of hemocyte proliferation" NARROW [] synonym: "positive regulation of arthropod blood cell proliferation" EXACT [] synonym: "stimulation of hemocyte proliferation" NARROW [] synonym: "up regulation of hemocyte proliferation" EXACT [] synonym: "up-regulation of hemocyte proliferation" EXACT [] synonym: "upregulation of hemocyte proliferation" EXACT [] is_a: GO:0002684 ! positive regulation of immune system process is_a: GO:0008284 ! positive regulation of cell population proliferation is_a: GO:0035206 ! regulation of hemocyte proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0035172 ! positively regulates hemocyte proliferation relationship: RO:0002213 GO:0035172 ! positively regulates hemocyte proliferation [Term] id: GO:0035234 name: ectopic germ cell programmed cell death namespace: biological_process def: "Programmed cell death of an errant germ line cell that is outside the normal migratory path or ectopic to the gonad. This is an important mechanism of regulating germ cell survival within the embryo." [PMID:12814944] synonym: "programmed cell death of ectopic germ cells" EXACT [] synonym: "programmed cell death, ectopic germ cells" EXACT [] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0010623 ! programmed cell death involved in cell development intersection_of: GO:0012501 ! programmed cell death intersection_of: BFO:0000066 CL:0000586 ! occurs in germ cell relationship: BFO:0000066 CL:0000586 ! occurs in germ cell [Term] id: GO:0035235 name: ionotropic glutamate receptor signaling pathway namespace: biological_process def: "The series of molecular signals initiated by glutamate binding to a glutamate receptor on the surface of the target cell, followed by the movement of ions through a channel in the receptor complex, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:signaling, ISBN:0198506732] synonym: "ionotropic glutamate receptor signalling pathway" EXACT [] is_a: GO:0007215 ! glutamate receptor signaling pathway is_a: GO:1990806 ! ligand-gated ion channel signaling pathway intersection_of: GO:0007165 ! signal transduction intersection_of: RO:0002224 GO:0004970 ! starts with glutamate-gated receptor activity relationship: RO:0002224 GO:0004970 ! starts with glutamate-gated receptor activity [Term] id: GO:0035239 name: tube morphogenesis namespace: biological_process def: "The process in which the anatomical structures of a tube are generated and organized. Epithelial and endothelial tubes transport gases, liquids and cells from one site to another and form the basic structure of many organs and tissues, with tube shape and organization varying from the single-celled excretory organ in Caenorhabditis elegans to the branching trees of the mammalian kidney and insect tracheal system." [GOC:bf, PMID:14624839] is_a: BFO:0000003 is_a: GO:0009653 ! anatomical structure morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0000025 ! results in morphogenesis of tube relationship: BFO:0000050 GO:0035295 ! part of tube development relationship: RO:0002298 UBERON:0000025 ! results in morphogenesis of tube [Term] id: GO:0035240 name: dopamine binding namespace: molecular_function def: "Binding to dopamine, a catecholamine neurotransmitter formed by aromatic-L-amino-acid decarboxylase from 3,4-dihydroxy-L-phenylalanine." [ISBN:0198506732] is_a: GO:0043169 ! cation binding is_a: GO:1901338 ! catecholamine binding intersection_of: GO:0005488 ! binding intersection_of: RO:0004009 CHEBI:59905 ! has primary input relationship: RO:0004009 CHEBI:59905 ! has primary input [Term] id: GO:0035249 name: synaptic transmission, glutamatergic namespace: biological_process def: "The vesicular release of glutamate from a presynapse, across a chemical synapse, the subsequent activation of glutamate receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse." [GOC:dos] synonym: "glutamatergic synaptic transmission" EXACT [] is_a: GO:0007268 ! chemical synaptic transmission [Term] id: GO:0035260 name: internal genitalia morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the internal genitalia are generated and organized. The internal genitalia are the internal sex organs such as the uterine tube, the uterus and the vagina in female mammals, and the testis, seminal vesicle, ejaculatory duct and prostate in male mammals." [PMID:24793987, PMID:25247640] is_a: GO:0035112 ! genitalia morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0004175 ! results in morphogenesis of internal genitalia relationship: RO:0002298 UBERON:0004175 ! results in morphogenesis of internal genitalia [Term] id: GO:0035261 name: external genitalia morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the external genitalia are generated and organized. The external genitalia are the outer sex organs, such as the penis or vulva in mammals." [PMID:24793987, PMID:25247640] is_a: GO:0035112 ! genitalia morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0004176 ! results in morphogenesis of external genitalia relationship: RO:0002298 UBERON:0004176 ! results in morphogenesis of external genitalia [Term] id: GO:0035262 name: gonad morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the gonads are generated and organized. A gonad is an animal organ producing gametes, e.g. the testes or the ovary in mammals." [ISBN:0198612001] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0009887 ! animal organ morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0000991 ! results in morphogenesis of gonad relationship: BFO:0000050 GO:0008406 ! part of gonad development relationship: RO:0002298 UBERON:0000991 ! results in morphogenesis of gonad [Term] id: GO:0035264 name: multicellular organism growth namespace: biological_process def: "The increase in size or mass of an entire multicellular organism, as opposed to cell growth." [GOC:bf, GOC:curators, GOC:dph, GOC:tb] synonym: "body growth" RELATED [] is_a: BFO:0000003 is_a: GO:0032501 ! multicellular organismal process is_a: GO:0048589 ! developmental growth intersection_of: GO:0048589 ! developmental growth intersection_of: RO:0002343 UBERON:0000468 ! results in growth of multicellular organism relationship: RO:0002343 UBERON:0000468 ! results in growth of multicellular organism property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0035265 name: organ growth namespace: biological_process def: "The increase in size or mass of an organ. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that function together as to perform a specific function." [GOC:bf, ISBN:0471245208, ISBN:0721662544] is_a: BFO:0000003 is_a: GO:0032501 ! multicellular organismal process is_a: GO:0048589 ! developmental growth intersection_of: GO:0048589 ! developmental growth intersection_of: RO:0002343 UBERON:0000062 ! results in growth of organ relationship: RO:0002343 UBERON:0000062 ! results in growth of organ property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0035270 name: endocrine system development namespace: biological_process def: "Progression of the endocrine system over time, from its formation to a mature structure. The endocrine system is a system of hormones and ductless glands, where the glands release hormones directly into the blood, lymph or other intercellular fluid, and the hormones circulate within the body to affect distant organs. The major glands that make up the human endocrine system are the hypothalamus, pituitary, thyroid, parathryoids, adrenals, pineal body, and the reproductive glands which include the ovaries and testes." [GOC:bf, Wikipedia:Development_of_the_endocrine_system] is_a: GO:0048731 ! system development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0000949 ! results in development of endocrine system relationship: RO:0002296 UBERON:0000949 ! results in development of endocrine system [Term] id: GO:0035272 name: exocrine system development namespace: biological_process def: "Progression of the exocrine system over time, from its formation to a mature structure. The exocrine system is a system of hormones and glands, where the glands secrete straight to a target site via ducts or tubes. The human exocrine system includes the salivary glands, sweat glands and many glands of the digestive system." [GOC:bf, Wikipedia:Exocrine_gland] is_a: GO:0048731 ! system development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0002330 ! results in development of exocrine system relationship: RO:0002296 UBERON:0002330 ! results in development of exocrine system [Term] id: GO:0035282 name: segmentation namespace: biological_process def: "The regionalization process that divides an organism or part of an organism into a series of semi-repetitive parts, or segments, often arranged along a longitudinal axis." [PMID:10611687, PMID:9706689] xref: Wikipedia:Segmentation_(biology) is_a: GO:0003002 ! regionalization property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0035290 name: trunk segmentation namespace: biological_process def: "Partitioning of the blastoderm embryo into trunk segmental units. In Drosophila, the trunk segments include thoracic segments and abdominal segments A1 to A8." [PMID:1360402] is_a: GO:0035282 ! segmentation relationship: BFO:0000050 GO:0007350 ! part of blastoderm segmentation property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0035295 name: tube development namespace: biological_process def: "The process whose specific outcome is the progression of a tube over time, from its initial formation to a mature structure. Epithelial and endothelial tubes transport gases, liquids and cells from one site to another and form the basic structure of many organs and tissues including lung and trachea, kidney, the mammary gland, the vascular system and the gastrointestinal and urinary-genital tracts." [PMID:12526790] is_a: GO:0048856 ! anatomical structure development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0000025 ! results in development of tube relationship: BFO:0000050 GO:0007275 ! part of multicellular organism development relationship: RO:0002162 NCBITaxon:6072 ! in taxon Eumetazoa relationship: RO:0002296 UBERON:0000025 ! results in development of tube [Term] id: GO:0035315 name: hair cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a hair cell." [GOC:bf] is_a: GO:0009913 ! epidermal cell differentiation is_a: GO:0030182 ! neuron differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000855 ! results in acquisition of features of sensory hair cell relationship: RO:0002315 CL:0000855 ! results in acquisition of features of sensory hair cell [Term] id: GO:0035316 name: non-sensory hair organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of non-sensory hairs. These hairs are polarized cellular extensions that cover much of the insect epidermis." [GOC:mtg_sensu, PMID:11064425] comment: See also the fly_anatomy.ontology term 'trichome ; FBbt:00004979'. synonym: "non-sensory hair organization and biogenesis" RELATED [GOC:mah] synonym: "trichome organisation" BROAD [] synonym: "trichome organization and biogenesis" BROAD [] is_a: GO:0120036 ! plasma membrane bounded cell projection organization intersection_of: GO:0016043 ! cellular component organization intersection_of: RO:0002592 GO:0070451 ! results in organization of cell hair relationship: BFO:0000050 GO:0035315 ! part of hair cell differentiation relationship: RO:0002162 NCBITaxon:6656 ! in taxon Arthropoda relationship: RO:0002592 GO:0070451 ! results in organization of cell hair [Term] id: GO:0035322 name: mesenchymal cell migration involved in limb bud formation namespace: biological_process def: "The orderly movement of a mesenchymal cell from one site to another that will contribute to the formation of a limb bud." [GOC:dgh] is_a: GO:0090497 ! mesenchymal cell migration intersection_of: GO:0090497 ! mesenchymal cell migration intersection_of: BFO:0000050 GO:0060174 ! part of limb bud formation relationship: BFO:0000050 GO:0090496 ! part of mesenchyme migration involved in limb bud formation creation_date: 2010-02-24T02:05:14Z [Term] id: GO:0035369 name: pre-B cell receptor complex namespace: cellular_component def: "An immunoglobulin-like complex that is present in at least the plasma membrane of pre-B cells, and that is composed of two identical immunoglobulin heavy chains and two surrogate light chains, each composed of the lambda-5 and VpreB proteins, and a signaling subunit, a heterodimer of the Ig-alpha and Ig-beta proteins." [GOC:add, ISBN:0781765196, PMID:16464608, PMID:17306522] comment: Despite its name, the pre-BCR is not a receptor complex, as it appears to provide a low level of signal not dependent on a ligand, but rather simply on correct assembly of the complex as a measure for correct Ig heavy chain recombination and folding. A significant proportion of pre-BCR complexes fail to reach the cell surface, and in some cases may provide their signaling function from the trans-Golgi network or lysosome. synonym: "pre-BCR" EXACT [] is_a: GO:0098796 ! membrane protein complex creation_date: 2010-03-11T10:46:10Z [Term] id: GO:0035372 name: protein localization to microtubule namespace: biological_process def: "A process in which a protein is transported to, or maintained at, a microtubule." [GOC:bf, GOC:lb] synonym: "protein localisation to microtubule" EXACT [GOC:mah] is_a: GO:0072698 ! protein localization to microtubule cytoskeleton intersection_of: GO:0008104 ! intracellular protein localization intersection_of: RO:0002339 GO:0005874 ! has target end location microtubule relationship: RO:0002339 GO:0005874 ! has target end location microtubule creation_date: 2010-03-11T11:00:56Z [Term] id: GO:0035374 name: chondroitin sulfate binding namespace: molecular_function def: "Binding to chondroitin sulfate, a glycosaminoglycan made up of two alternating monosaccharides: D-glucuronic acid (GlcA) and N-acetyl-D-galactosamine (GalNAc)." [GOC:kmv, ISBN:0198506732] is_a: GO:0005539 ! glycosaminoglycan binding is_a: GO:1901681 ! sulfur compound binding intersection_of: GO:0005488 ! binding intersection_of: RO:0004009 CHEBI:37397 ! has primary input relationship: RO:0004009 CHEBI:37397 ! has primary input creation_date: 2010-03-12T10:25:34Z [Term] id: GO:0035377 name: transepithelial water transport namespace: biological_process def: "The directed movement of water (H2O) from one side of an epithelium to the other." [GOC:yaf] is_a: GO:0006833 ! water transport is_a: GO:0042045 ! epithelial fluid transport intersection_of: GO:0042044 ! fluid transport intersection_of: RO:0002342 UBERON:0000483 ! results in transport across epithelium intersection_of: RO:0004009 CHEBI:15377 ! has primary input creation_date: 2010-03-18T10:55:38Z [Term] id: GO:0035381 name: ATP-gated ion channel activity namespace: molecular_function def: "Enables the transmembrane transfer of an ion by a channel that opens when ATP has been bound by the channel complex or one of its constituent parts." [GOC:bf] is_a: GO:0022834 ! ligand-gated channel activity intersection_of: GO:0022834 ! ligand-gated channel activity intersection_of: RO:0004009 CHEBI:24870 ! has primary input intersection_of: RO:0012001 CHEBI:30616 ! has small molecule activator relationship: RO:0004009 CHEBI:24870 ! has primary input relationship: RO:0012001 CHEBI:30616 ! has small molecule activator creation_date: 2010-03-18T01:21:45Z [Term] id: GO:0035418 name: protein localization to synapse namespace: biological_process def: "Any process in which a protein is transported to, and/or maintained at the synapse, the junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell." [GOC:bf] synonym: "protein localisation to synapse" EXACT [GOC:mah] is_a: GO:1902414 ! protein localization to cell junction intersection_of: GO:0008104 ! intracellular protein localization intersection_of: RO:0002339 GO:0045202 ! has target end location synapse relationship: RO:0002339 GO:0045202 ! has target end location synapse creation_date: 2010-03-29T10:58:53Z [Term] id: GO:0035435 name: phosphate ion transmembrane transport namespace: biological_process def: "The process in which a phosphate is transported across a membrane." [GOC:vw] comment: Note that this term is not intended for use in annotating lateral movement within membranes. synonym: "phosphate ion membrane transport" EXACT [] is_a: GO:0006817 ! phosphate ion transport is_a: GO:0055085 ! transmembrane transport intersection_of: GO:0055085 ! transmembrane transport intersection_of: RO:0004009 CHEBI:43474 ! has primary input creation_date: 2010-04-08T11:24:06Z [Term] id: GO:0035441 name: cell migration involved in vasculogenesis namespace: biological_process def: "The orderly movement of a cell from one site to another that will contribute to the differentiation of an endothelial cell that will form de novo blood vessels and tubes." [GOC:dgh] is_a: GO:0016477 ! cell migration intersection_of: GO:0016477 ! cell migration intersection_of: BFO:0000050 GO:0001570 ! part of vasculogenesis relationship: BFO:0000050 GO:0001570 ! part of vasculogenesis creation_date: 2010-04-09T03:53:01Z [Term] id: GO:0035490 name: regulation of leukotriene production involved in inflammatory response namespace: biological_process def: "Any process that modulates the rate, frequency or extent of the synthesis or release of any leukotriene following a stimulus as part of an inflammatory response." [GOC:bf] is_a: GO:0051239 ! regulation of multicellular organismal process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0002540 ! regulates leukotriene production involved in inflammatory response relationship: RO:0002211 GO:0002540 ! regulates leukotriene production involved in inflammatory response creation_date: 2010-04-26T10:49:22Z [Term] id: GO:0035491 name: positive regulation of leukotriene production involved in inflammatory response namespace: biological_process def: "Any process that increases the rate, frequency or extent of the synthesis or release of any leukotriene following a stimulus as part of an inflammatory response." [GOC:bf] is_a: GO:0035490 ! regulation of leukotriene production involved in inflammatory response is_a: GO:0050729 ! positive regulation of inflammatory response is_a: GO:0051240 ! positive regulation of multicellular organismal process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0002540 ! positively regulates leukotriene production involved in inflammatory response relationship: RO:0002213 GO:0002540 ! positively regulates leukotriene production involved in inflammatory response creation_date: 2010-04-26T10:50:14Z [Term] id: GO:0035492 name: negative regulation of leukotriene production involved in inflammatory response namespace: biological_process def: "Any process that decreases the rate, frequency or extent of the synthesis or release of any leukotriene following a stimulus as part of an inflammatory response." [GOC:bf] is_a: GO:0035490 ! regulation of leukotriene production involved in inflammatory response is_a: GO:0050728 ! negative regulation of inflammatory response is_a: GO:0051241 ! negative regulation of multicellular organismal process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0002540 ! negatively regulates leukotriene production involved in inflammatory response relationship: RO:0002212 GO:0002540 ! negatively regulates leukotriene production involved in inflammatory response creation_date: 2010-04-26T10:50:55Z [Term] id: GO:0035493 name: SNARE complex assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form a SNARE complex, a protein complex involved in membrane fusion; a stable ternary complex consisting of a four-helix bundle, usually formed from one R-SNARE and three Q-SNAREs with an ionic layer sandwiched between hydrophobic layers." [GOC:rb, PMID:10872468] is_a: GO:0065003 ! protein-containing complex assembly intersection_of: GO:0022607 ! cellular component assembly intersection_of: RO:0002588 GO:0031201 ! results in assembly of SNARE complex relationship: BFO:0000050 GO:0006906 ! part of vesicle fusion relationship: RO:0002588 GO:0031201 ! results in assembly of SNARE complex creation_date: 2010-04-26T02:50:52Z [Term] id: GO:0035494 name: SNARE complex disassembly namespace: biological_process def: "The disaggregation of the SNARE protein complex into its constituent components. The SNARE complex is a protein complex involved in membrane fusion; a stable ternary complex consisting of a four-helix bundle, usually formed from one R-SNARE and three Q-SNAREs with an ionic layer sandwiched between hydrophobic layers." [GOC:rb, PMID:11697877] is_a: GO:0032984 ! protein-containing complex disassembly intersection_of: GO:0022411 ! cellular component disassembly intersection_of: RO:0002590 GO:0031201 ! results in disassembly of SNARE complex relationship: BFO:0000050 GO:0016192 ! part of vesicle-mediated transport relationship: RO:0002590 GO:0031201 ! results in disassembly of SNARE complex creation_date: 2010-04-26T02:54:17Z [Term] id: GO:0035495 name: regulation of SNARE complex disassembly namespace: biological_process def: "Any process that modulates the frequency, rate or extent of disassembly of the SNARE complex. The SNARE complex is a protein complex involved in membrane fusion; a stable ternary complex consisting of a four-helix bundle, usually formed from one R-SNARE and three Q-SNAREs with an ionic layer sandwiched between hydrophobic layers." [GOC:rb] is_a: GO:0043244 ! regulation of protein-containing complex disassembly intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0035494 ! regulates SNARE complex disassembly relationship: RO:0002211 GO:0035494 ! regulates SNARE complex disassembly creation_date: 2010-04-26T02:56:53Z [Term] id: GO:0035540 name: positive regulation of SNARE complex disassembly namespace: biological_process def: "Any process that increases the frequency, rate or extent of disassembly of the SNARE complex. The SNARE complex is a protein complex involved in membrane fusion; a stable ternary complex consisting of a four-helix bundle, usually formed from one R-SNARE and three Q-SNAREs with an ionic layer sandwiched between hydrophobic layers." [GOC:rb] is_a: GO:0035495 ! regulation of SNARE complex disassembly is_a: GO:0043243 ! positive regulation of protein-containing complex disassembly is_a: GO:0051050 ! positive regulation of transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0035494 ! positively regulates SNARE complex disassembly relationship: RO:0002213 GO:0035494 ! positively regulates SNARE complex disassembly creation_date: 2010-05-10T01:42:21Z [Term] id: GO:0035541 name: negative regulation of SNARE complex disassembly namespace: biological_process def: "Any process that decreases the frequency, rate or extent of disassembly of the SNARE complex. The SNARE complex is a protein complex involved in membrane fusion; a stable ternary complex consisting of a four-helix bundle, usually formed from one R-SNARE and three Q-SNAREs with an ionic layer sandwiched between hydrophobic layers." [GOC:rb] is_a: GO:0035495 ! regulation of SNARE complex disassembly is_a: GO:0043242 ! negative regulation of protein-containing complex disassembly is_a: GO:0051051 ! negative regulation of transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0035494 ! negatively regulates SNARE complex disassembly relationship: RO:0002212 GO:0035494 ! negatively regulates SNARE complex disassembly creation_date: 2010-05-10T01:42:47Z [Term] id: GO:0035542 name: regulation of SNARE complex assembly namespace: biological_process def: "Any process that modulates the frequency, rate or extent of assembly of the SNARE complex. The SNARE complex is a protein complex involved in membrane fusion; a stable ternary complex consisting of a four-helix bundle, usually formed from one R-SNARE and three Q-SNAREs with an ionic layer sandwiched between hydrophobic layers." [GOC:rb] is_a: GO:0043254 ! regulation of protein-containing complex assembly intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0035493 ! regulates SNARE complex assembly relationship: RO:0002211 GO:0035493 ! regulates SNARE complex assembly creation_date: 2010-05-10T01:49:35Z [Term] id: GO:0035543 name: positive regulation of SNARE complex assembly namespace: biological_process def: "Any process that increases the frequency, rate or extent of assembly of the SNARE complex. The SNARE complex is a protein complex involved in membrane fusion; a stable ternary complex consisting of a four-helix bundle, usually formed from one R-SNARE and three Q-SNAREs with an ionic layer sandwiched between hydrophobic layers." [GOC:rb] is_a: GO:0031334 ! positive regulation of protein-containing complex assembly is_a: GO:0031340 ! positive regulation of vesicle fusion is_a: GO:0035542 ! regulation of SNARE complex assembly intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0035493 ! positively regulates SNARE complex assembly relationship: RO:0002213 GO:0035493 ! positively regulates SNARE complex assembly creation_date: 2010-05-10T01:50:02Z [Term] id: GO:0035544 name: negative regulation of SNARE complex assembly namespace: biological_process def: "Any process that decreases the frequency, rate or extent of assembly of the SNARE complex. The SNARE complex is a protein complex involved in membrane fusion; a stable ternary complex consisting of a four-helix bundle, usually formed from one R-SNARE and three Q-SNAREs with an ionic layer sandwiched between hydrophobic layers." [GOC:rb] is_a: GO:0031333 ! negative regulation of protein-containing complex assembly is_a: GO:0031339 ! negative regulation of vesicle fusion is_a: GO:0035542 ! regulation of SNARE complex assembly intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0035493 ! negatively regulates SNARE complex assembly relationship: RO:0002212 GO:0035493 ! negatively regulates SNARE complex assembly creation_date: 2010-05-10T01:51:10Z [Term] id: GO:0035556 name: intracellular signal transduction namespace: biological_process def: "The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782] subset: goslim_drosophila synonym: "intracellular signal transduction pathway" NARROW [] synonym: "intracellular signaling cascade" RELATED [GOC:signaling] synonym: "intracellular signaling pathway" RELATED [] synonym: "signal transmission via intracellular cascade" NARROW [] is_a: GO:0007165 ! signal transduction intersection_of: GO:0007165 ! signal transduction intersection_of: BFO:0000066 GO:0005622 ! occurs in intracellular anatomical structure relationship: BFO:0000066 GO:0005622 ! occurs in intracellular anatomical structure creation_date: 2010-05-14T01:14:37Z [Term] id: GO:0035562 name: negative regulation of chromatin binding namespace: biological_process def: "Any process that stops or reduces the frequency, rate or extent of chromatin binding. Chromatin binding is the selective interaction with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase." [GOC:bf, PMID:20404130] subset: gocheck_do_not_annotate is_a: GO:0051100 ! negative regulation of binding intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0003682 ! negatively regulates chromatin binding relationship: RO:0002212 GO:0003682 ! negatively regulates chromatin binding creation_date: 2010-05-19T10:29:06Z [Term] id: GO:0035563 name: positive regulation of chromatin binding namespace: biological_process def: "Any process that increases the frequency, rate or extent of chromatin binding. Chromatin binding is the selective interaction with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase." [GOC:bf, PMID:20404130] subset: gocheck_do_not_annotate is_a: GO:0051099 ! positive regulation of binding intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0003682 ! positively regulates chromatin binding relationship: RO:0002213 GO:0003682 ! positively regulates chromatin binding creation_date: 2010-05-19T10:29:41Z [Term] id: GO:0035577 name: azurophil granule membrane namespace: cellular_component def: "The lipid bilayer surrounding an azurophil granule, a primary lysosomal granule found in neutrophil granulocytes that contains a wide range of hydrolytic enzymes and is released into the extracellular fluid." [GOC:bf, PMID:17152095] synonym: "primary granule membrane" EXACT [] is_a: GO:0005765 ! lysosomal membrane is_a: GO:0030667 ! secretory granule membrane intersection_of: GO:0016020 ! membrane intersection_of: RO:0002007 GO:0042582 ! bounding layer of azurophil granule relationship: RO:0002007 GO:0042582 ! bounding layer of azurophil granule property_value: RO:0002161 NCBITaxon:4751 creation_date: 2010-10-05T01:29:10Z [Term] id: GO:0035589 name: G protein-coupled purinergic nucleotide receptor signaling pathway namespace: biological_process def: "A G protein-coupled receptor signaling pathway initiated by an extracellular purine nucleotide binding to its receptor, and ending with the regulation of a downstream cellular process." [GOC:BHF, PMID:9755289] synonym: "G-protein coupled purinergic nucleotide receptor signaling pathway" EXACT [] synonym: "G-protein coupled purinergic nucleotide receptor signalling pathway" EXACT [GOC:mah] synonym: "P2Y receptor signaling pathway" EXACT [PMID:9755289] is_a: GO:0035590 ! purinergic nucleotide receptor signaling pathway creation_date: 2010-10-22T11:18:59Z [Term] id: GO:0035590 name: purinergic nucleotide receptor signaling pathway namespace: biological_process def: "The series of molecular signals initiated by an extracellular purine nucleotide binding to its receptor, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:BHF, PMID:9755289] synonym: "P2 receptor signaling pathway" RELATED [PMID:9755289] synonym: "purinergic nucleotide receptor signalling pathway" EXACT [GOC:mah] synonym: "purinergic receptor signaling pathway" RELATED [] synonym: "purinergic receptor signalling pathway" RELATED [GOC:mah] synonym: "purinoceptor signaling pathway" RELATED [PMID:9755289] xref: Reactome:R-HSA-9660826 "Purinergic signaling in leishmaniasis infection" is_a: GO:0007166 ! cell surface receptor signaling pathway creation_date: 2010-10-22T11:09:40Z [Term] id: GO:0035592 name: establishment of protein localization to extracellular region namespace: biological_process def: "The directed movement of a protein to a specific location within the extracellular region." [GOC:bf, GOC:BHF] synonym: "establishment of protein localisation in extracellular region" EXACT [GOC:mah] synonym: "establishment of protein localization in extracellular region" EXACT [] is_a: GO:0045184 ! establishment of protein localization intersection_of: GO:0045184 ! establishment of protein localization intersection_of: RO:0002339 GO:0005576 ! has target end location extracellular region relationship: RO:0002339 GO:0005576 ! has target end location extracellular region creation_date: 2010-11-09T10:25:08Z [Term] id: GO:0035622 name: intrahepatic bile duct development namespace: biological_process def: "The progression of the intrahepatic bile ducts over time, from their formation to the mature structure. Intrahepatic bile ducts (bile ducts within the liver) collect bile from bile canaliculi in the liver, and connect to the extrahepatic bile ducts (bile ducts outside the liver)." [GOC:bf, PMID:20614624] synonym: "IHBD development" EXACT [PMID:20614624] synonym: "intrahepatic biliary duct development" EXACT [PMID:20614624] is_a: GO:0061009 ! common bile duct development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0003704 ! results in development of intrahepatic bile duct relationship: BFO:0000050 GO:0001889 ! part of liver development relationship: RO:0002296 UBERON:0003704 ! results in development of intrahepatic bile duct creation_date: 2010-12-08T04:10:50Z [Term] id: GO:0035628 name: cystic duct development namespace: biological_process def: "The progression of the cystic duct over time, from its formation to the mature structure. The cystic duct runs from the gallbladder to the common bile duct." [PMID:20614624] is_a: GO:0061009 ! common bile duct development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0001152 ! results in development of cystic duct relationship: RO:0002296 UBERON:0001152 ! results in development of cystic duct creation_date: 2010-12-10T01:24:28Z [Term] id: GO:0035630 name: bone mineralization involved in bone maturation namespace: biological_process def: "The deposition of hydroxyapatite, involved in the progression of the skeleton from its formation to its mature state." [GOC:bf, GOC:BHF] comment: Bone mineralization can also occur after a fracture and as a response to stress; in these cases, consider using the term 'bone mineralization ; GO:0030282'. is_a: GO:0030282 ! bone mineralization intersection_of: GO:0030282 ! bone mineralization intersection_of: BFO:0000050 GO:0043931 ! part of ossification involved in bone maturation relationship: BFO:0000050 GO:0043931 ! part of ossification involved in bone maturation creation_date: 2010-12-20T01:57:31Z [Term] id: GO:0035639 name: purine ribonucleoside triphosphate binding namespace: molecular_function def: "Binding to a purine ribonucleoside triphosphate, a compound consisting of a purine base linked to a ribose sugar esterified with triphosphate on the sugar." [GOC:BHF, GOC:ebc, ISBN:0198506732] synonym: "purine NTP binding" BROAD [GOC:ebc] is_a: GO:0043168 ! anion binding is_a: GO:1901265 ! nucleoside phosphate binding is_a: GO:1901363 ! heterocyclic compound binding intersection_of: GO:0005488 ! binding intersection_of: RO:0004009 CHEBI:26398 ! has primary input relationship: RO:0004009 CHEBI:26398 ! has primary input creation_date: 2011-01-14T02:46:42Z [Term] id: GO:0035645 name: enteric smooth muscle cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a smooth muscle cell of the intestine." [CL:0002504, GOC:BHF] synonym: "intestinal smooth muscle cell differentiation" EXACT [CL:0002504] is_a: GO:0051145 ! smooth muscle cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0002504 ! results in acquisition of features of enteric smooth muscle cell relationship: BFO:0000050 GO:0048565 ! part of digestive tract development relationship: RO:0002315 CL:0002504 ! results in acquisition of features of enteric smooth muscle cell creation_date: 2011-01-21T02:58:58Z [Term] id: GO:0035675 name: neuromast hair cell development namespace: biological_process def: "The process whose specific outcome is the progression of a neuromast hair cell over time, from its formation to the mature structure. A neuromast hair cell is a hair cell that acts as a sensory receptor of the neuromast; it is morphologically polarized as a result of the relative position of the single kinocilium and the clusters of stereocilia on its apical surface. Cell development does not include the steps involved in committing a cell to a specific fate." [CL:0000856] is_a: GO:0048666 ! neuron development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 CL:0000856 ! results in development of neuromast hair cell relationship: BFO:0000050 GO:0048886 ! part of neuromast hair cell differentiation relationship: RO:0002296 CL:0000856 ! results in development of neuromast hair cell creation_date: 2011-02-14T11:01:42Z [Term] id: GO:0035676 name: anterior lateral line neuromast hair cell development namespace: biological_process def: "The process whose specific outcome is the progression of an anterior lateral line neuromast hair cell over time, from its formation to the mature structure. A neuromast hair cell is a hair cell that acts as a sensory receptor of the neuromast; it is morphologically polarized as a result of the relative position of the single kinocilium and the clusters of stereocilia on its apical surface. Cell development does not include the steps involved in committing a cell to a specific fate." [ISBN:0125296509, ISBN:0387968377] is_a: GO:0035675 ! neuromast hair cell development intersection_of: GO:0048468 ! cell development intersection_of: RO:0002296 CL:2000034 ! results in development of anterior lateral line neuromast hair cell relationship: BFO:0000050 GO:0048903 ! part of anterior lateral line neuromast hair cell differentiation relationship: RO:0002296 CL:2000034 ! results in development of anterior lateral line neuromast hair cell creation_date: 2011-02-14T11:03:57Z [Term] id: GO:0035677 name: posterior lateral line neuromast hair cell development namespace: biological_process def: "The process whose specific outcome is the progression of a posterior lateral line neuromast hair cell over time, from its formation to the mature structure. A neuromast hair cell is a hair cell that acts as a sensory receptor of the neuromast; it is morphologically polarized as a result of the relative position of the single kinocilium and the clusters of stereocilia on its apical surface. Cell development does not include the steps involved in committing a cell to a specific fate." [ISBN:0125296509] is_a: GO:0035675 ! neuromast hair cell development intersection_of: GO:0048468 ! cell development intersection_of: RO:0002296 CL:2000037 ! results in development of posterior lateral line neuromast hair cell relationship: BFO:0000050 GO:0048923 ! part of posterior lateral line neuromast hair cell differentiation relationship: RO:0002296 CL:2000037 ! results in development of posterior lateral line neuromast hair cell creation_date: 2011-02-14T11:04:57Z [Term] id: GO:0035678 name: neuromast hair cell morphogenesis namespace: biological_process def: "The change in form (cell shape and size) that occurs when a neuromast hair cell progresses from its initial formation to its mature state. A neuromast hair cell is a hair cell that acts as a sensory receptor of the neuromast; it is morphologically polarized as a result of the relative position of the single kinocilium and the clusters of stereocilia on its apical surface." [CL:0000856] is_a: GO:0048667 ! cell morphogenesis involved in neuron differentiation intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 CL:0000856 ! results in morphogenesis of neuromast hair cell relationship: BFO:0000050 GO:0035675 ! part of neuromast hair cell development relationship: RO:0002298 CL:0000856 ! results in morphogenesis of neuromast hair cell creation_date: 2011-02-14T11:06:15Z [Term] id: GO:0035694 name: mitochondrial protein catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of a mitochondrial protein. This process is necessary to maintain the healthy state of mitochondria and is thought to occur via the induction of an intramitochondrial lysosome-like organelle that acts to eliminate the damaged oxidised mitochondrial proteins without destroying the mitochondrial structure." [GOC:sp, PMID:21264221, PMID:21264228] synonym: "catabolism of mitochondrial protein" EXACT [GOC:bf] synonym: "degradation of damaged mitochondrial protein" EXACT [GOC:bf] xref: Reactome:R-HSA-9837999 "Mitochondrial protein degradation" is_a: GO:0030163 ! protein catabolic process intersection_of: GO:0030163 ! protein catabolic process intersection_of: BFO:0000066 GO:0005739 ! occurs in mitochondrion relationship: BFO:0000050 GO:0007005 ! part of mitochondrion organization relationship: BFO:0000066 GO:0005739 ! occurs in mitochondrion relationship: RO:0002162 NCBITaxon:2759 ! in taxon Eukaryota creation_date: 2011-02-28T11:06:40Z [Term] id: GO:0035700 name: astrocyte chemotaxis namespace: biological_process def: "The directed movement of an astrocyte guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis)." [CL:0000127, GOC:BHF, PMID:12271471] is_a: GO:0043615 ! astrocyte cell migration is_a: GO:0060326 ! cell chemotaxis intersection_of: GO:0006935 ! chemotaxis intersection_of: RO:0002565 CL:0000127 ! results in movement of astrocyte creation_date: 2011-02-28T03:17:52Z [Term] id: GO:0035701 name: hematopoietic stem cell migration namespace: biological_process def: "The orderly movement of a hematopoietic stem cell from one site to another. A hematopoietic stem cell is a cell from which all cells of the lymphoid and myeloid lineages develop, including blood cells and cells of the immune system." [CL:0000037, GOC:BHF, PMID:20234092] synonym: "hemopoietic stem cell migration" EXACT [CL:0000037] is_a: BFO:0000003 is_a: GO:0016477 ! cell migration intersection_of: GO:0016477 ! cell migration intersection_of: RO:0002565 CL:0000037 ! results in movement of hematopoietic stem cell relationship: RO:0002565 CL:0000037 ! results in movement of hematopoietic stem cell property_value: RO:0002161 NCBITaxon:4890 creation_date: 2011-02-28T03:20:36Z [Term] id: GO:0035702 name: monocyte homeostasis namespace: biological_process def: "The process of regulating the proliferation and elimination of monocytes such that the total number of monocytes within a whole or part of an organism is stable over time in the absence of an outside stimulus." [CL:0000576, GOC:BHF, PMID:18832716] is_a: GO:0001776 ! leukocyte homeostasis is_a: GO:0002262 ! myeloid cell homeostasis intersection_of: GO:0048872 ! homeostasis of number of cells intersection_of: RO:0012003 CL:0000576 ! acts on population of monocyte relationship: RO:0012003 CL:0000576 ! acts on population of monocyte creation_date: 2011-03-02T11:32:57Z [Term] id: GO:0035704 name: helper T cell chemotaxis namespace: biological_process def: "The directed movement of a helper T cell in response to an external stimulus." [CL:0000912, GOC:BHF] synonym: "T-helper cell chemotaxis" EXACT [CL:0000912] is_a: GO:0010818 ! T cell chemotaxis intersection_of: GO:0006935 ! chemotaxis intersection_of: RO:0002565 CL:0000912 ! results in movement of helper T cell relationship: RO:0002565 CL:0000912 ! results in movement of helper T cell creation_date: 2011-03-02T02:31:48Z [Term] id: GO:0035705 name: T-helper 17 cell chemotaxis namespace: biological_process def: "The directed movement of a T-helper 17 cell in response to an external stimulus." [CL:0000899, GOC:BHF] synonym: "Th17 cell chemotaxis" EXACT [CL:0000899] is_a: GO:0010818 ! T cell chemotaxis intersection_of: GO:0006935 ! chemotaxis intersection_of: RO:0002565 CL:0000899 ! results in movement of T-helper 17 cell relationship: RO:0002565 CL:0000899 ! results in movement of T-helper 17 cell creation_date: 2011-03-02T02:35:16Z [Term] id: GO:0035706 name: T-helper 1 cell chemotaxis namespace: biological_process def: "The directed movement of a T-helper 1 cell in response to an external stimulus." [CL:0000545, GOC:BHF] synonym: "Th1 cell chemotaxis" EXACT [CL:0000545] is_a: GO:0010818 ! T cell chemotaxis intersection_of: GO:0006935 ! chemotaxis intersection_of: RO:0002565 CL:0000545 ! results in movement of T-helper 1 cell relationship: RO:0002565 CL:0000545 ! results in movement of T-helper 1 cell creation_date: 2011-03-02T02:36:49Z [Term] id: GO:0035707 name: T-helper 2 cell chemotaxis namespace: biological_process def: "The directed movement of a T-helper 2 cell in response to an external stimulus." [CL:0000546, GOC:BHF] synonym: "Th2 cell chemotaxis" EXACT [CL:0000546] is_a: GO:0010818 ! T cell chemotaxis intersection_of: GO:0006935 ! chemotaxis intersection_of: RO:0002565 CL:0000546 ! results in movement of T-helper 2 cell relationship: RO:0002565 CL:0000546 ! results in movement of T-helper 2 cell creation_date: 2011-03-02T02:37:44Z [Term] id: GO:0035709 name: memory T cell activation namespace: biological_process def: "The change in morphology and behavior of a memory T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific." [CL:0000813, GOC:BHF] is_a: GO:0042110 ! T cell activation intersection_of: GO:0001775 ! cell activation intersection_of: RO:0004009 CL:0000813 ! has primary input memory T cell relationship: RO:0004009 CL:0000813 ! has primary input memory T cell creation_date: 2011-03-02T03:03:02Z [Term] id: GO:0035710 name: CD4-positive, alpha-beta T cell activation namespace: biological_process def: "The change in morphology and behavior of a CD4-positive, alpha-beta T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific." [CL:0000624, GOC:BHF] is_a: GO:0046631 ! alpha-beta T cell activation intersection_of: GO:0001775 ! cell activation intersection_of: RO:0004009 CL:0000624 ! has primary input CD4-positive, alpha-beta T cell relationship: RO:0004009 CL:0000624 ! has primary input CD4-positive, alpha-beta T cell creation_date: 2011-03-02T03:04:11Z [Term] id: GO:0035711 name: T-helper 1 cell activation namespace: biological_process def: "The change in morphology and behavior of a T-helper 1 cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific." [CL:0000545, GOC:BHF] synonym: "Th1 cell activation" EXACT [CL:0000545] is_a: GO:0035710 ! CD4-positive, alpha-beta T cell activation intersection_of: GO:0001775 ! cell activation intersection_of: RO:0004009 CL:0000545 ! has primary input T-helper 1 cell relationship: RO:0004009 CL:0000545 ! has primary input T-helper 1 cell creation_date: 2011-03-02T03:05:08Z [Term] id: GO:0035712 name: T-helper 2 cell activation namespace: biological_process def: "The change in morphology and behavior of a T helper 2 cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific." [CL:0000546, GOC:BHF] synonym: "Th2 cell activation" EXACT [CL:0000546] is_a: GO:0035710 ! CD4-positive, alpha-beta T cell activation intersection_of: GO:0001775 ! cell activation intersection_of: RO:0004009 CL:0000546 ! has primary input T-helper 2 cell relationship: RO:0004009 CL:0000546 ! has primary input T-helper 2 cell creation_date: 2011-03-02T03:05:59Z [Term] id: GO:0035719 name: tRNA import into nucleus namespace: biological_process def: "The directed movement of tRNA from the cytoplasm to the nucleus." [GOC:vw, PMID:20032305] synonym: "retrograde tRNA transport into nucleus" EXACT [GOC:vw, PMID:20032305] synonym: "tRNA nuclear import" EXACT [GOC:vw] is_a: GO:0006404 ! RNA import into nucleus is_a: GO:0051031 ! tRNA transport intersection_of: GO:0006810 ! transport intersection_of: RO:0002338 GO:0005829 ! has target start location cytosol intersection_of: RO:0002339 GO:0031981 ! has target end location nuclear lumen intersection_of: RO:0002342 GO:0005635 ! results in transport across nuclear envelope intersection_of: RO:0004009 CHEBI:17843 ! has primary input creation_date: 2011-03-03T04:32:35Z [Term] id: GO:0035725 name: sodium ion transmembrane transport namespace: biological_process def: "A process in which a sodium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:vw] comment: Note that this term is not intended for use in annotating lateral movement within membranes. synonym: "sodium ion membrane transport" EXACT [] is_a: GO:0006814 ! sodium ion transport is_a: GO:0098655 ! monoatomic cation transmembrane transport intersection_of: GO:0055085 ! transmembrane transport intersection_of: RO:0004009 CHEBI:29101 ! has primary input creation_date: 2011-03-10T02:52:36Z [Term] id: GO:0035733 name: hepatic stellate cell activation namespace: biological_process def: "A change in the morphology or behavior of a hepatic stellate cell resulting from exposure to a cytokine, chemokine, hormone, cellular ligand or soluble factor." [CL:0000632, GOC:bf] is_a: GO:0072537 ! fibroblast activation intersection_of: GO:0001775 ! cell activation intersection_of: RO:0004009 CL:0000632 ! has primary input hepatic stellate cell relationship: RO:0004009 CL:0000632 ! has primary input hepatic stellate cell creation_date: 2011-03-11T10:04:12Z [Term] id: GO:0035735 name: intraciliary transport involved in cilium assembly namespace: biological_process def: "The bidirectional movement of large protein complexes along microtubules within a cilium that contributes to cilium assembly." [GOC:bf, GOC:cilia] synonym: "intraciliary transport involved in cilium morphogenesis" RELATED [] synonym: "intraflagellar transport" BROAD [] synonym: "intraflagellar transport involved in cilium morphogenesis" RELATED [] xref: Reactome:R-HSA-5620924 "Intraflagellar transport" is_a: GO:0042073 ! intraciliary transport intersection_of: GO:0042073 ! intraciliary transport intersection_of: BFO:0000050 GO:0060271 ! part of cilium assembly relationship: BFO:0000050 GO:0060271 ! part of cilium assembly property_value: RO:0002161 NCBITaxon:3176 property_value: RO:0002161 NCBITaxon:3378 property_value: RO:0002161 NCBITaxon:3398 property_value: RO:0002161 NCBITaxon:4890 property_value: RO:0002161 NCBITaxon:5782 creation_date: 2011-03-17T10:55:42Z [Term] id: GO:0035736 name: cell proliferation involved in compound eye morphogenesis namespace: biological_process def: "The multiplication or reproduction of cells, resulting in the expansion of a cell population that contributes to compound eye morphogenesis." [GOC:bf, GOC:sart] is_a: GO:0008283 ! cell population proliferation intersection_of: GO:0008283 ! cell population proliferation intersection_of: BFO:0000050 GO:0001745 ! part of compound eye morphogenesis relationship: BFO:0000050 GO:0001745 ! part of compound eye morphogenesis creation_date: 2011-03-17T10:57:03Z [Term] id: GO:0035739 name: CD4-positive, alpha-beta T cell proliferation namespace: biological_process def: "The expansion of a CD4-positive, alpha-beta T cell population by cell division." [CL:0000624, GOC:BHF] is_a: GO:0035710 ! CD4-positive, alpha-beta T cell activation is_a: GO:0046633 ! alpha-beta T cell proliferation intersection_of: GO:0008283 ! cell population proliferation intersection_of: RO:0012003 CL:0000624 ! acts on population of CD4-positive, alpha-beta T cell relationship: RO:0012003 CL:0000624 ! acts on population of CD4-positive, alpha-beta T cell creation_date: 2011-03-17T02:12:48Z [Term] id: GO:0035740 name: CD8-positive, alpha-beta T cell proliferation namespace: biological_process def: "The expansion of a CD8-positive, alpha-beta T cell population by cell division." [CL:0000625, GOC:BHF] is_a: GO:0036037 ! CD8-positive, alpha-beta T cell activation is_a: GO:0046633 ! alpha-beta T cell proliferation intersection_of: GO:0008283 ! cell population proliferation intersection_of: RO:0012003 CL:0000625 ! acts on population of CD8-positive, alpha-beta T cell relationship: RO:0012003 CL:0000625 ! acts on population of CD8-positive, alpha-beta T cell creation_date: 2011-03-17T02:13:54Z [Term] id: GO:0035741 name: activated CD4-positive, alpha-beta T cell proliferation namespace: biological_process def: "The expansion of an activated CD4-positive, alpha-beta T cell population by cell division." [CL:0000896, GOC:BHF] is_a: GO:0035739 ! CD4-positive, alpha-beta T cell proliferation intersection_of: GO:0008283 ! cell population proliferation intersection_of: RO:0012003 CL:0000896 ! acts on population of activated CD4-positive, alpha-beta T cell relationship: RO:0012003 CL:0000896 ! acts on population of activated CD4-positive, alpha-beta T cell creation_date: 2011-03-17T02:18:39Z [Term] id: GO:0035742 name: activated CD8-positive, alpha-beta T cell proliferation namespace: biological_process def: "The expansion of an activated CD8-positive, alpha-beta T cell population by cell division." [CL:0000906, GOC:BHF] is_a: GO:0035740 ! CD8-positive, alpha-beta T cell proliferation intersection_of: GO:0008283 ! cell population proliferation intersection_of: RO:0012003 CL:0000906 ! acts on population of activated CD8-positive, alpha-beta T cell relationship: RO:0012003 CL:0000906 ! acts on population of activated CD8-positive, alpha-beta T cell creation_date: 2011-03-17T02:19:58Z [Term] id: GO:0035743 name: CD4-positive, alpha-beta T cell cytokine production namespace: biological_process def: "Any process that contributes to cytokine production by a CD4-positive, alpha-beta T cell." [CL:0000624, GOC:BHF] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms. subset: gocheck_do_not_annotate is_a: GO:0002369 ! T cell cytokine production intersection_of: GO:0001816 ! cytokine production intersection_of: RO:0002608 CL:0000624 ! process has causal agent CD4-positive, alpha-beta T cell relationship: RO:0002608 CL:0000624 ! process has causal agent CD4-positive, alpha-beta T cell creation_date: 2011-03-17T02:21:51Z [Term] id: GO:0035744 name: T-helper 1 cell cytokine production namespace: biological_process def: "Any process that contributes to cytokine production by a T-helper 1 cell." [CL:0000545, GOC:BHF] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms. subset: gocheck_do_not_annotate synonym: "Th1 cell cytokine production" EXACT [CL:0000545] is_a: GO:0035743 ! CD4-positive, alpha-beta T cell cytokine production intersection_of: GO:0001816 ! cytokine production intersection_of: RO:0002608 CL:0000545 ! process has causal agent T-helper 1 cell relationship: BFO:0000050 GO:0042088 ! part of T-helper 1 type immune response relationship: RO:0002608 CL:0000545 ! process has causal agent T-helper 1 cell creation_date: 2011-03-17T02:22:54Z [Term] id: GO:0035745 name: T-helper 2 cell cytokine production namespace: biological_process def: "Any process that contributes to cytokine production by a T-helper 2 cell." [CL:0000546, GOC:BHF] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms. subset: gocheck_do_not_annotate synonym: "Th2 cell cytokine production" EXACT [CL:0000546] is_a: GO:0035743 ! CD4-positive, alpha-beta T cell cytokine production intersection_of: GO:0001816 ! cytokine production intersection_of: RO:0002608 CL:0000546 ! process has causal agent T-helper 2 cell relationship: BFO:0000050 GO:0042092 ! part of type 2 immune response relationship: RO:0002608 CL:0000546 ! process has causal agent T-helper 2 cell creation_date: 2011-03-17T02:23:32Z [Term] id: GO:0035747 name: natural killer cell chemotaxis namespace: biological_process def: "The directed movement of a natural killer cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis)." [CL:0000623, GOC:BHF] is_a: GO:0048247 ! lymphocyte chemotaxis intersection_of: GO:0006935 ! chemotaxis intersection_of: RO:0002565 CL:0000623 ! results in movement of natural killer cell relationship: RO:0002565 CL:0000623 ! results in movement of natural killer cell creation_date: 2011-03-17T02:40:10Z [Term] id: GO:0035754 name: B cell chemotaxis namespace: biological_process def: "The directed movement of a B cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis)." [CL:0000236, GOC:BHF] is_a: GO:0048247 ! lymphocyte chemotaxis intersection_of: GO:0006935 ! chemotaxis intersection_of: RO:0002565 CL:0000236 ! results in movement of B cell relationship: RO:0002565 CL:0000236 ! results in movement of B cell creation_date: 2011-03-23T10:30:33Z [Term] id: GO:0035767 name: endothelial cell chemotaxis namespace: biological_process def: "The directed movement of an endothelial cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis)." [CL:0000115, GOC:BHF] is_a: GO:0043542 ! endothelial cell migration is_a: GO:0060326 ! cell chemotaxis intersection_of: GO:0006935 ! chemotaxis intersection_of: RO:0002565 CL:0000115 ! results in movement of endothelial cell property_value: RO:0002161 NCBITaxon:451864 creation_date: 2011-03-31T04:31:37Z [Term] id: GO:0035773 name: insulin secretion involved in cellular response to glucose stimulus namespace: biological_process def: "The regulated release of proinsulin from secretory granules (B granules) in the B cells of the pancreas; accompanied by cleavage of proinsulin to form mature insulin, in response to a glucose stimulus." [GOC:bf, GOC:yaf, PMID:8492079] synonym: "insulin secretion involved in cellular response to glucose" EXACT [GOC:bf] is_a: GO:0030073 ! insulin secretion is_a: GO:0051649 ! establishment of localization in cell intersection_of: GO:0030073 ! insulin secretion intersection_of: BFO:0000050 GO:0071333 ! part of cellular response to glucose stimulus relationship: BFO:0000050 GO:0071333 ! part of cellular response to glucose stimulus creation_date: 2011-04-01T01:14:40Z [Term] id: GO:0035774 name: positive regulation of insulin secretion involved in cellular response to glucose stimulus namespace: biological_process def: "Any process that increases the frequency, rate or extent of the regulated release of insulin that contributes to the response of a cell to glucose." [GOC:bf, GOC:yaf] synonym: "positive regulation of insulin secretion in response to glucose" EXACT [GOC:bf] is_a: GO:0032024 ! positive regulation of insulin secretion is_a: GO:0061178 ! regulation of insulin secretion involved in cellular response to glucose stimulus intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0035773 ! positively regulates insulin secretion involved in cellular response to glucose stimulus relationship: RO:0002213 GO:0035773 ! positively regulates insulin secretion involved in cellular response to glucose stimulus creation_date: 2011-04-01T01:49:09Z [Term] id: GO:0035775 name: pronephric glomerulus morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the pronephric glomerulus are generated and organized. The pronephric glomerulus is part of the pronephric nephron and is restricted to one body segment." [GOC:mtg_kidney_jan10, GOC:yaf, PMID:18787069] comment: This term is intended for annotation of fish and other organisms which contain a glomerulus as part of the pronephric nephron. It should not be used for annotation of Xenopus, which contains a pronephric glomus rather than a glomerulus. is_a: GO:0072102 ! glomerulus morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0004739 ! results in morphogenesis of pronephric glomerulus relationship: BFO:0000050 GO:0039021 ! part of pronephric glomerulus development relationship: RO:0002298 UBERON:0004739 ! results in morphogenesis of pronephric glomerulus creation_date: 2011-04-04T10:59:28Z [Term] id: GO:0035776 name: pronephric proximal tubule development namespace: biological_process def: "The progression of the pronephric proximal tubule over time, from its formation to the mature structure. A pronephric nephron tubule is an epithelial tube that is part of the pronephros." [GOC:mtg_kidney_jan10, GOC:yaf, PMID:18787069] is_a: GO:0039020 ! pronephric nephron tubule development is_a: GO:0072014 ! proximal tubule development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0006173 ! results in development of pronephric proximal tubule relationship: RO:0002296 UBERON:0006173 ! results in development of pronephric proximal tubule creation_date: 2011-04-04T11:02:54Z [Term] id: GO:0035777 name: pronephric distal tubule development namespace: biological_process def: "The process whose specific outcome is the progression of the pronephric distal tubule over time, from its formation to the mature structure. A pronephric nephron tubule is an epithelial tube that is part of the pronephros." [GOC:mtg_kidney_jan10, GOC:yaf, PMID:18787069] is_a: GO:0039020 ! pronephric nephron tubule development is_a: GO:0072017 ! distal tubule development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0006175 ! results in development of pronephric distal tubule relationship: RO:0002296 UBERON:0006175 ! results in development of pronephric distal tubule creation_date: 2011-04-04T11:06:01Z [Term] id: GO:0035778 name: pronephric nephron tubule epithelial cell differentiation namespace: biological_process def: "The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the cells of the pronephric nephron tubule as it progresses from its formation to the mature state." [GOC:mtg_kidney_jan10, GOC:yaf, PMID:18787069] is_a: GO:0039014 ! cell differentiation involved in pronephros development is_a: GO:0072160 ! nephron tubule epithelial cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:1000090 ! results in acquisition of features of pronephric nephron tubule epithelial cell relationship: BFO:0000050 GO:0039020 ! part of pronephric nephron tubule development relationship: RO:0002315 CL:1000090 ! results in acquisition of features of pronephric nephron tubule epithelial cell creation_date: 2011-04-04T11:07:47Z [Term] id: GO:0035779 name: angioblast cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of an angioblast cell. Angioblasts are one of the two products formed from hemangioblast cells (the other being pluripotent hemopoietic stem cells)." [CL:0000566, GOC:yaf] synonym: "angioblastic mesenchymal cell differentiation" EXACT [CL:0000566] is_a: GO:0048863 ! stem cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000566 ! results in acquisition of features of angioblastic mesenchymal cell relationship: BFO:0000050 GO:0001568 ! part of blood vessel development relationship: RO:0002315 CL:0000566 ! results in acquisition of features of angioblastic mesenchymal cell creation_date: 2011-04-04T11:10:38Z [Term] id: GO:0035787 name: cell migration involved in kidney development namespace: biological_process def: "The orderly movement of a cell from one site to another that will contribute to the progression of the kidney over time, from its formation to the mature organ." [GOC:bf, GOC:mtg_kidney_jan10, GOC:yaf] is_a: GO:0016477 ! cell migration intersection_of: GO:0016477 ! cell migration intersection_of: BFO:0000050 GO:0001822 ! part of kidney development relationship: BFO:0000050 GO:0001822 ! part of kidney development creation_date: 2011-04-06T10:39:52Z [Term] id: GO:0035788 name: cell migration involved in metanephros development namespace: biological_process def: "The orderly movement of a cell from one site to another that will contribute to the progression of the metanephric kidney over time, from its formation to the mature organ." [GOC:bf, GOC:mtg_kidney_jan10, GOC:yaf] synonym: "cell migration involved in metanephric kidney development" EXACT [GOC:bf] is_a: GO:0035787 ! cell migration involved in kidney development intersection_of: GO:0016477 ! cell migration intersection_of: BFO:0000050 GO:0001656 ! part of metanephros development relationship: BFO:0000050 GO:0001656 ! part of metanephros development creation_date: 2011-04-06T10:42:21Z [Term] id: GO:0035799 name: ureter maturation namespace: biological_process def: "A developmental process, independent of morphogenetic (shape) change, that is required for the ureter to attain its fully functional state. The ureter is a muscular tube that transports urine from the kidney to the urinary bladder or from the Malpighian tubule to the hindgut." [GOC:bf, GOC:mtg_kidney_jan10, GOC:yaf, PMID:17881463] is_a: GO:0048799 ! animal organ maturation intersection_of: GO:0071695 ! anatomical structure maturation intersection_of: RO:0002299 UBERON:0000056 ! results in maturation of ureter relationship: BFO:0000050 GO:0072189 ! part of ureter development relationship: RO:0002299 UBERON:0000056 ! results in maturation of ureter creation_date: 2011-04-14T01:13:39Z [Term] id: GO:0035801 name: adrenal cortex development namespace: biological_process def: "The process whose specific outcome is the progression of the adrenal cortex over time, from its formation to the mature structure. The adrenal cortex is located at the periphery of the adrenal gland and controls glucose and electrolyte metabolism, response to stress and sexual development through the production of different classes of steroid hormones (glucocorticoids, mineralocorticoids and androgens)." [PMID:12185666, PMID:21115154, Wikipedia:Adrenal_cortex] synonym: "adrenal gland cortex development" EXACT [MA:0000118] is_a: GO:0048856 ! anatomical structure development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0001235 ! results in development of adrenal cortex relationship: BFO:0000050 GO:0030325 ! part of adrenal gland development relationship: RO:0002296 UBERON:0001235 ! results in development of adrenal cortex creation_date: 2011-04-18T10:25:39Z [Term] id: GO:0035802 name: adrenal cortex formation namespace: biological_process def: "The process that gives rise to the adrenal cortex. This process pertains to the initial formation of a structure from unspecified parts. The adrenogonadal primordium from which the adrenal cortex is formed derives from a condensation of coelomic epithelial cells (the urogenital ridge; the same structure from which gonads and kidney also originate)." [PMID:12185666, PMID:21115154] synonym: "adrenal gland cortex formation" EXACT [MA:0000118] is_a: BFO:0000003 is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0001235 ! results in formation of anatomical entity adrenal cortex relationship: BFO:0000050 GO:0035801 ! part of adrenal cortex development relationship: RO:0002297 UBERON:0001235 ! results in formation of anatomical entity adrenal cortex creation_date: 2011-04-18T10:26:49Z [Term] id: GO:0035809 name: regulation of urine volume namespace: biological_process def: "Any process that modulates the amount of urine excreted from the body over a unit of time." [GOC:mtg_25march11, GOC:yaf] synonym: "regulation of urinary volume" EXACT [] synonym: "regulation of urine flow" EXACT [] is_a: GO:0003014 ! renal system process is_a: GO:0050878 ! regulation of body fluid levels property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 creation_date: 2011-04-20T01:17:38Z [Term] id: GO:0035844 name: cloaca development namespace: biological_process def: "The process whose specific outcome is the progression of the cloaca over time, from it's formation to the mature structure. The cloaca is the common chamber into which intestinal, genital and urinary canals open in vertebrates." [GOC:dgh, ISBN:0582227089] synonym: "cloacal development" EXACT [GOC:bf] is_a: GO:0048856 ! anatomical structure development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0000162 ! results in development of cloaca relationship: BFO:0000050 GO:0001655 ! part of urogenital system development relationship: BFO:0000050 GO:0048546 ! part of digestive tract morphogenesis relationship: RO:0002296 UBERON:0000162 ! results in development of cloaca creation_date: 2011-05-06T01:54:35Z [Term] id: GO:0035846 name: oviduct epithelium development namespace: biological_process def: "The progression of the oviduct epithelium over time from its initial formation to the mature structure. An oviduct is a tube through which an ova passes from the ovary to the uterus, or from the ovary to the outside of the organism. The oviduct epithelium is the specialized epithelium that lines the oviduct." [GOC:yaf, PMID:34496237] synonym: "fallopian tube epithelium development" NARROW [GOC:yaf] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0060429 ! epithelium development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0004804 ! results in development of oviduct epithelium relationship: BFO:0000050 GO:0060066 ! part of oviduct development relationship: RO:0002296 UBERON:0004804 ! results in development of oviduct epithelium creation_date: 2011-05-10T10:53:05Z [Term] id: GO:0035847 name: uterine epithelium development namespace: biological_process def: "The progression of an epithelium of the uterus over time from its initial formation to the mature structure. An epithelium is a tissue that covers the internal or external surfaces of an anatomical structure." [GOC:bf, GOC:yaf] synonym: "uterus epithelial development" EXACT [GOC:yaf] is_a: GO:0035846 ! oviduct epithelium development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0006955 ! results in development of uterine epithelium relationship: BFO:0000050 GO:0060065 ! part of uterus development relationship: RO:0002296 UBERON:0006955 ! results in development of uterine epithelium creation_date: 2011-05-10T10:57:45Z [Term] id: GO:0035848 name: oviduct morphogenesis namespace: biological_process def: "The process in which anatomical structures of the oviduct are generated and organized. An oviduct is a tube through which an ova passes from the ovary to the uterus, or from the ovary to the outside of the organism." [GOC:yaf, PMID:22918811] synonym: "fallopian tube morphogenesis" NARROW [GOC:yaf] is_a: GO:0009887 ! animal organ morphogenesis is_a: GO:0035239 ! tube morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0000993 ! results in morphogenesis of oviduct relationship: BFO:0000050 GO:0060066 ! part of oviduct development relationship: RO:0002298 UBERON:0000993 ! results in morphogenesis of oviduct creation_date: 2011-05-10T11:01:20Z [Term] id: GO:0035850 name: epithelial cell differentiation involved in kidney development namespace: biological_process def: "The process in which relatively unspecialized cells acquire specialized structural and/or functional features of an epithelial cell that characterize the cells of the kidney as it progresses from its formation to the mature state." [GOC:bf, GOC:mtg_kidney_jan10, GOC:yaf, PMID:16216236] is_a: GO:0030855 ! epithelial cell differentiation is_a: GO:0061005 ! cell differentiation involved in kidney development intersection_of: GO:0030855 ! epithelial cell differentiation intersection_of: BFO:0000050 GO:0001822 ! part of kidney development creation_date: 2011-05-11T11:34:21Z [Term] id: GO:0035855 name: megakaryocyte development namespace: biological_process def: "The process whose specific outcome is the progression of a megakaryocyte cell over time, from its formation to the mature structure. Megakaryocyte development does not include the steps involved in committing a cell to a megakaryocyte fate. A megakaryocyte is a giant cell 50 to 100 micron in diameter, with a greatly lobulated nucleus, found in the bone marrow." [CL:0000556, GOC:BHF, GOC:vk] synonym: "megakaryocyte cell development" EXACT [GOC:bf] is_a: GO:0061515 ! myeloid cell development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 CL:0000556 ! results in development of megakaryocyte relationship: BFO:0000050 GO:0030219 ! part of megakaryocyte differentiation relationship: RO:0002296 CL:0000556 ! results in development of megakaryocyte creation_date: 2011-05-13T01:28:06Z [Term] id: GO:0035864 name: response to potassium ion namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a potassium ion stimulus." [GOC:yaf] synonym: "response to K+ ion" EXACT [GOC:bf] synonym: "response to potassium" EXACT [GOC:bf] is_a: GO:0010038 ! response to metal ion intersection_of: GO:0050896 ! response to stimulus intersection_of: RO:0004009 CHEBI:29103 ! has primary input relationship: RO:0004009 CHEBI:29103 ! has primary input creation_date: 2011-05-25T02:58:45Z [Term] id: GO:0035865 name: cellular response to potassium ion namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a potassium ion stimulus." [GOC:yaf] synonym: "cellular response to K+ ion" EXACT [GOC:bf] synonym: "cellular response to potassium" EXACT [GOC:bf] is_a: GO:0035864 ! response to potassium ion is_a: GO:0071248 ! cellular response to metal ion intersection_of: GO:0070887 ! cellular response to chemical stimulus intersection_of: RO:0004009 CHEBI:29103 ! has primary input creation_date: 2011-05-25T02:59:11Z [Term] id: GO:0035869 name: ciliary transition zone namespace: cellular_component def: "A region of the cilium between the basal body and proximal segment that is characterized by Y-shaped assemblages that connect axonemal microtubules to the ciliary membrane. The ciliary transition zone appears to function as a gate that controls ciliary membrane composition and separates the cytosol from the ciliary plasm." [GOC:cilia, GOC:kmv, PMID:21422230] comment: Depending on the species, this region may have a distinct geometrically shaped electron-dense structure within the axonemal lumen visible in electron microscopy images; most animals don't display this inner structure. The axoneme extends through the ciliary transition zone, but only consists of the outer doublets. The central pair, axonemal spokes, and dynein complexes are not found in this part of the ciliary shaft. Note that the connecting cilium of the photoreceptor cells is thought to be equivalent to the transition zone. synonym: "cilial transition zone" EXACT [] synonym: "cilium transition zone" EXACT [] synonym: "connecting cilium" RELATED [] is_a: GO:0110165 ! cellular anatomical structure relationship: BFO:0000050 GO:0005929 ! part of cilium property_value: RO:0002161 NCBITaxon:3176 property_value: RO:0002161 NCBITaxon:3378 property_value: RO:0002161 NCBITaxon:3398 property_value: RO:0002161 NCBITaxon:4890 property_value: RO:0002161 NCBITaxon:5782 creation_date: 2011-05-25T03:09:58Z [Term] id: GO:0035878 name: nail development namespace: biological_process def: "The process whose specific outcome is the progression of a nail over time, from its formation to the mature structure. A nail is a horn-like envelope covering the outer end of a finger or toe, and consists of the nail plate, the nail matrix and the nail bed below it, and the grooves surrounding it." [GOC:bf, ISBN:0323025781, UBERON:0001705, Wikipedia:Nail_(anatomy)] is_a: GO:0048856 ! anatomical structure development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0001705 ! results in development of nail relationship: BFO:0000050 GO:0060173 ! part of limb development relationship: RO:0002162 NCBITaxon:32523 ! in taxon Tetrapoda relationship: RO:0002296 UBERON:0001705 ! results in development of nail creation_date: 2011-05-31T02:30:34Z [Term] id: GO:0035881 name: amacrine cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of an amacrine cell, an interneuron generated in the inner nuclear layer (INL) of the vertebrate retina. Amacrine cells integrate, modulate, and interpose a temporal domain in the visual message presented to the retinal ganglion cells, with which they synapse in the inner plexiform layer. Amacrine cells lack large axons." [CL:0000561, GOC:bf] synonym: "amacrine neuron differentiation" EXACT [CL:0000561] is_a: GO:0021953 ! central nervous system neuron differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000561 ! results in acquisition of features of amacrine cell relationship: BFO:0000050 GO:0003407 ! part of neural retina development relationship: RO:0002315 CL:0000561 ! results in acquisition of features of amacrine cell creation_date: 2011-06-06T11:32:50Z [Term] id: GO:0035883 name: enteroendocrine cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized structural and/or functional features of an enteroendocrine cell. Enteroendocrine cells are hormonally active epithelial cells in the gut that constitute the diffuse neuroendocrine system." [CL:0000164, GOC:bf] is_a: GO:0030855 ! epithelial cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000164 ! results in acquisition of features of enteroendocrine cell relationship: RO:0002315 CL:0000164 ! results in acquisition of features of enteroendocrine cell creation_date: 2011-06-06T11:48:51Z [Term] id: GO:0035886 name: vascular associated smooth muscle cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a vascular smooth muscle cell." [GOC:sl, PMID:16151017, PMID:18267954] synonym: "vascular smooth muscle cell differentiation" EXACT [] synonym: "VSMC differentiation" EXACT [PMID:16151017] is_a: GO:0051145 ! smooth muscle cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000359 ! results in acquisition of features of vascular associated smooth muscle cell relationship: BFO:0000050 GO:0001944 ! part of vasculature development relationship: RO:0002315 CL:0000359 ! results in acquisition of features of vascular associated smooth muscle cell creation_date: 2011-06-08T11:23:52Z [Term] id: GO:0035887 name: aortic smooth muscle cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a smooth muscle cell surrounding the aorta." [GOC:sl] is_a: GO:0035886 ! vascular associated smooth muscle cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0002539 ! results in acquisition of features of aortic smooth muscle cell relationship: RO:0002315 CL:0002539 ! results in acquisition of features of aortic smooth muscle cell creation_date: 2011-06-08T11:34:26Z [Term] id: GO:0035898 name: parathyroid hormone secretion namespace: biological_process def: "The regulated release of parathyroid hormone into the circulatory system." [GOC:cjm, PMID:12171519, PMID:21164021] synonym: "parathormone secretion" EXACT [PR:000013429] synonym: "parathyrin secretion" EXACT [PR:000013429] synonym: "PTH secretion" EXACT [PMID:12171519, PR:000013429] is_a: GO:0060986 ! endocrine hormone secretion property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 creation_date: 2011-06-22T09:28:54Z [Term] id: GO:0035904 name: aorta development namespace: biological_process def: "The progression of the aorta over time, from its initial formation to the mature structure. An aorta is an artery that carries blood from the heart to other parts of the body." [GOC:bf, GOC:dgh, MA:0000062, UBERON:0000947, Wikipedia:Aorta] is_a: GO:0060840 ! artery development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0000947 ! results in development of aorta relationship: RO:0002296 UBERON:0000947 ! results in development of aorta creation_date: 2011-06-24T11:00:07Z [Term] id: GO:0035905 name: ascending aorta development namespace: biological_process def: "The progression of the ascending aorta over time, from its initial formation to the mature structure. The ascending aorta is the portion of the aorta in a two-pass circulatory system that lies between the heart and the arch of aorta. In a two-pass circulatory system blood passes twice through the heart to supply the body once." [GOC:bf, GOC:dgh, MA:0002570, UBERON:0001496, Wikipedia:Ascending_aorta] is_a: GO:0048856 ! anatomical structure development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0001496 ! results in development of ascending aorta relationship: BFO:0000050 GO:0035904 ! part of aorta development relationship: RO:0002296 UBERON:0001496 ! results in development of ascending aorta creation_date: 2011-06-24T11:02:01Z [Term] id: GO:0035906 name: descending aorta development namespace: biological_process def: "The progression of the descending aorta over time, from its initial formation to the mature structure. The descending aorta is the portion of the aorta in a two-pass circulatory system from the arch of aorta to the point where it divides into the common iliac arteries. In a two-pass circulatory system blood passes twice through the heart to supply the body once." [GOC:bf, GOC:dgh, MA:0002571, UBERON:0001514, Wikipedia:Descending_aorta] is_a: GO:0048856 ! anatomical structure development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0001514 ! results in development of descending aorta relationship: BFO:0000050 GO:0035904 ! part of aorta development relationship: RO:0002296 UBERON:0001514 ! results in development of descending aorta creation_date: 2011-06-24T11:05:22Z [Term] id: GO:0035907 name: dorsal aorta development namespace: biological_process def: "The progression of the dorsal aorta over time, from its initial formation to the mature structure. The dorsal aorta is a blood vessel in a single-pass circulatory system that carries oxygenated blood from the gills to the rest of the body. In a single-pass circulatory system blood passes once through the heart to supply the body once." [GOC:bf, GOC:dgh, UBERON:0005805, Wikipedia:Aorta, ZFA:0000014] is_a: GO:0035904 ! aorta development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0005805 ! results in development of dorsal aorta relationship: RO:0002296 UBERON:0005805 ! results in development of dorsal aorta creation_date: 2011-06-24T11:07:01Z [Term] id: GO:0035909 name: aorta morphogenesis namespace: biological_process def: "The process in which the anatomical structures of an aorta are generated and organized. An aorta is an artery that carries blood from the heart to other parts of the body." [GOC:bf, GOC:dgh, MA:0000062, UBERON:0000947, Wikipedia:Aorta] is_a: GO:0048844 ! artery morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0000947 ! results in morphogenesis of aorta relationship: BFO:0000050 GO:0035904 ! part of aorta development relationship: RO:0002298 UBERON:0000947 ! results in morphogenesis of aorta creation_date: 2011-06-24T11:11:11Z [Term] id: GO:0035910 name: ascending aorta morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the ascending aorta are generated and organized. The ascending aorta is the portion of the aorta in a two-pass circulatory system that lies between the heart and the arch of aorta. In a two-pass circulatory system blood passes twice through the heart to supply the body once." [GOC:bf, GOC:dgh, MA:0002570, UBERON:0001496, Wikipedia:Ascending_aorta] is_a: BFO:0000003 is_a: GO:0009653 ! anatomical structure morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0001496 ! results in morphogenesis of ascending aorta relationship: BFO:0000050 GO:0035905 ! part of ascending aorta development relationship: BFO:0000050 GO:0035909 ! part of aorta morphogenesis relationship: RO:0002298 UBERON:0001496 ! results in morphogenesis of ascending aorta creation_date: 2011-06-24T11:14:52Z [Term] id: GO:0035911 name: descending aorta morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the descending aorta are generated and organized. The descending aorta is the portion of the aorta in a two-pass circulatory system from the arch of aorta to the point where it divides into the common iliac arteries. In a two-pass circulatory system blood passes twice through the heart to supply the body once." [GOC:bf, GOC:dgh, MA:0002571, UBERON:0001514, Wikipedia:Descending_aorta] is_a: BFO:0000003 is_a: GO:0009653 ! anatomical structure morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0001514 ! results in morphogenesis of descending aorta relationship: BFO:0000050 GO:0035906 ! part of descending aorta development relationship: BFO:0000050 GO:0035909 ! part of aorta morphogenesis relationship: RO:0002298 UBERON:0001514 ! results in morphogenesis of descending aorta creation_date: 2011-06-24T11:19:24Z [Term] id: GO:0035912 name: dorsal aorta morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the dorsal aorta are generated and organized. The dorsal aorta is a blood vessel in a single-pass circulatory system that carries oxygenated blood from the gills to the rest of the body. In a single-pass circulatory system blood passes once through the heart to supply the body once." [GOC:bf, GOC:dgh, UBERON:0005805, Wikipedia:Aorta, ZFA:0000014] is_a: GO:0035909 ! aorta morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0005805 ! results in morphogenesis of dorsal aorta relationship: BFO:0000050 GO:0035907 ! part of dorsal aorta development relationship: RO:0002298 UBERON:0005805 ! results in morphogenesis of dorsal aorta creation_date: 2011-06-24T11:22:14Z [Term] id: GO:0035914 name: skeletal muscle cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a skeletal muscle cell, a somatic cell located in skeletal muscle." [CL:0000188, GOC:BHF, GOC:vk] is_a: GO:0030154 ! cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000188 ! results in acquisition of features of cell of skeletal muscle relationship: BFO:0000050 GO:0007519 ! part of skeletal muscle tissue development relationship: RO:0002315 CL:0000188 ! results in acquisition of features of cell of skeletal muscle creation_date: 2011-06-24T02:36:19Z [Term] id: GO:0035921 name: desmosome disassembly namespace: biological_process def: "The controlled breakdown of a desmosome. A desmosome is a patch-like intercellular junction found in vertebrate tissues, consisting of parallel zones of two cell membranes, separated by an space of 25-35 nm, and having dense fibrillar plaques in the subjacent cytoplasm." [GOC:BHF, GOC:vk, ISBN:0198506732, PMID:9182671] synonym: "desmosome dissociation" EXACT [PMID:9182671] is_a: GO:0002934 ! desmosome organization is_a: GO:0150147 ! cell-cell junction disassembly intersection_of: GO:0022411 ! cellular component disassembly intersection_of: RO:0002590 GO:0030057 ! results in disassembly of desmosome relationship: RO:0002590 GO:0030057 ! results in disassembly of desmosome creation_date: 2011-07-05T01:33:25Z [Term] id: GO:0035927 name: RNA import into mitochondrion namespace: biological_process def: "The process in which a rRNA, ribosomal ribonucleic acid, is transported from the cytosol into the mitochondrial matrix." [GOC:ans, PMID:20691904] synonym: "cytoplasmic RNA import into mitochondrion" NARROW [GOC:ans] synonym: "nuclear-encoded RNA import into mitochondrion" NARROW [GOC:bf] is_a: GO:0050658 ! RNA transport is_a: GO:0055085 ! transmembrane transport intersection_of: GO:0006810 ! transport intersection_of: RO:0002338 GO:0005829 ! has target start location cytosol intersection_of: RO:0002339 GO:0005759 ! has target end location mitochondrial matrix intersection_of: RO:0002342 GO:0031966 ! results in transport across mitochondrial membrane intersection_of: RO:0004009 CHEBI:33697 ! has primary input relationship: RO:0002338 GO:0005829 ! has target start location cytosol relationship: RO:0002339 GO:0005759 ! has target end location mitochondrial matrix relationship: RO:0002342 GO:0031966 ! results in transport across mitochondrial membrane creation_date: 2011-07-19T09:39:37Z [Term] id: GO:0035929 name: steroid hormone secretion namespace: biological_process def: "The regulated release of any steroid that acts as a hormone into the circulatory system." [GOC:sl] is_a: GO:0060986 ! endocrine hormone secretion is_a: GO:0140353 ! lipid export from cell intersection_of: GO:0046903 ! secretion intersection_of: RO:0004009 CHEBI:26764 ! has primary input relationship: RO:0004009 CHEBI:26764 ! has primary input property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 creation_date: 2011-07-20T01:01:00Z [Term] id: GO:0035930 name: corticosteroid hormone secretion namespace: biological_process def: "The regulated release of any corticosteroid hormone into the circulatory system." [GOC:sl] synonym: "corticosteroid secretion" BROAD [GOC:bf] is_a: GO:0035929 ! steroid hormone secretion intersection_of: GO:0046903 ! secretion intersection_of: RO:0004009 CHEBI:36699 ! has primary input relationship: RO:0004009 CHEBI:36699 ! has primary input property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 creation_date: 2011-07-20T01:03:22Z [Term] id: GO:0035931 name: mineralocorticoid secretion namespace: biological_process def: "The regulated release of any mineralocorticoid into the circulatory system. Mineralocorticoids are a class of steroid hormones that regulate water and electrolyte metabolism." [GOC:sl] is_a: GO:0035930 ! corticosteroid hormone secretion intersection_of: GO:0046903 ! secretion intersection_of: RO:0004009 CHEBI:25354 ! has primary input relationship: RO:0004009 CHEBI:25354 ! has primary input property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 creation_date: 2011-07-20T01:04:59Z [Term] id: GO:0035932 name: aldosterone secretion namespace: biological_process def: "The regulated release of aldosterone into the circulatory system. Aldosterone is a pregnane-based steroid hormone produced by the outer-section (zona glomerulosa) of the adrenal cortex in the adrenal gland, and acts on the distal tubules and collecting ducts of the kidney to cause the conservation of sodium, secretion of potassium, increased water retention, and increased blood pressure. The overall effect of aldosterone is to increase reabsorption of ions and water in the kidney." [GOC:sl] is_a: GO:0015850 ! organic hydroxy compound transport is_a: GO:0035931 ! mineralocorticoid secretion intersection_of: GO:0046903 ! secretion intersection_of: RO:0004009 CHEBI:27584 ! has primary input relationship: RO:0004009 CHEBI:27584 ! has primary input property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 creation_date: 2011-07-20T01:06:24Z [Term] id: GO:0035933 name: glucocorticoid secretion namespace: biological_process def: "The regulated release of any glucocorticoid hormone into the circulatory system. Glucocorticoids are a class of steroid hormones that regulate a variety of physiological processes, in particular control of the concentration of glucose in blood." [GOC:sl] is_a: GO:0035930 ! corticosteroid hormone secretion intersection_of: GO:0046903 ! secretion intersection_of: RO:0004009 CHEBI:24261 ! has primary input relationship: RO:0004009 CHEBI:24261 ! has primary input property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 creation_date: 2011-07-20T01:08:37Z [Term] id: GO:0035935 name: androgen secretion namespace: biological_process def: "The regulated release of an androgen into the circulatory system. Androgens are steroid hormones that stimulate or control the development and maintenance of masculine characteristics in vertebrates." [GOC:sl] is_a: GO:0035929 ! steroid hormone secretion property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 creation_date: 2011-07-20T01:11:31Z [Term] id: GO:0035936 name: testosterone secretion namespace: biological_process def: "The regulated release of testosterone into the circulatory system. Testosterone is an androgen having 17beta-hydroxy and 3-oxo groups, together with unsaturation at C-4-C-5." [GOC:sl, PMID:12606499] is_a: GO:0015850 ! organic hydroxy compound transport is_a: GO:0046879 ! hormone secretion is_a: GO:0140353 ! lipid export from cell intersection_of: GO:0046903 ! secretion intersection_of: RO:0004009 CHEBI:17347 ! has primary input relationship: RO:0004009 CHEBI:17347 ! has primary input creation_date: 2011-07-20T01:13:13Z [Term] id: GO:0035938 name: estradiol secretion namespace: biological_process def: "The regulated release of estradiol into the circulatory system." [GOC:sl, PMID:21632818] synonym: "oestradiol secretion" EXACT [] is_a: GO:0015850 ! organic hydroxy compound transport is_a: GO:0035929 ! steroid hormone secretion intersection_of: GO:0046903 ! secretion intersection_of: RO:0004009 CHEBI:23965 ! has primary input relationship: RO:0004009 CHEBI:23965 ! has primary input property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 creation_date: 2011-07-20T01:16:45Z [Term] id: GO:0035981 name: tongue muscle cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a tongue muscle cell." [CL:0002673, GOC:yaf, PMID:3393851] is_a: GO:0098528 ! skeletal muscle fiber differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0002673 ! results in acquisition of features of tongue muscle cell relationship: RO:0002315 CL:0002673 ! results in acquisition of features of tongue muscle cell creation_date: 2011-08-22T01:35:16Z [Term] id: GO:0035987 name: endodermal cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires the specialized features of an endoderm cell, a cell of the inner of the three germ layers of the embryo." [CL:0000223, GOC:yaf, PMID:17624332] synonym: "endoderm cell differentiation" EXACT [CL:0000223] is_a: GO:0030154 ! cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000223 ! results in acquisition of features of endodermal cell relationship: BFO:0000050 GO:0001706 ! part of endoderm formation relationship: RO:0002315 CL:0000223 ! results in acquisition of features of endodermal cell creation_date: 2011-08-25T04:50:36Z [Term] id: GO:0035989 name: tendon development namespace: biological_process def: "The process whose specific outcome is the progression of a tendon over time, from its formation to the mature structure. A tendon is a fibrous, strong, connective tissue that connects muscle to bone or integument and is capable of withstanding tension. Tendons and muscles work together to exert a pulling force." [GOC:yaf, PMID:21412429, UBERON:0000043] synonym: "sinew development" RELATED [UBERON:0000043] is_a: GO:0061448 ! connective tissue development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0000043 ! results in development of tendon relationship: RO:0002162 NCBITaxon:7742 ! in taxon Vertebrata relationship: RO:0002296 UBERON:0000043 ! results in development of tendon creation_date: 2011-08-26T04:14:30Z [Term] id: GO:0035990 name: tendon cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires the specialized features of a tendon cell. Tendon cell are elongated fibrocytes in which the cytoplasm is stretched between the collagen fibres of the tendon. Tendon cells have a central cell nucleus with a prominent nucleolus, a well-developed rough endoplasmic reticulum, and are responsible for synthesis and turnover of tendon fibres and ground substance." [CL:0000388, GOC:yaf, PMID:21412429] synonym: "muscle attachment cell differentiation" EXACT [CL:0000388] synonym: "tenocyte differentiation" RELATED [CL:0000388] is_a: GO:0030154 ! cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000388 ! results in acquisition of features of tendon cell relationship: BFO:0000050 GO:0035992 ! part of tendon formation relationship: RO:0002315 CL:0000388 ! results in acquisition of features of tendon cell creation_date: 2011-08-26T04:16:06Z [Term] id: GO:0035992 name: tendon formation namespace: biological_process def: "The process that gives rise to a tendon. This process pertains to the initial formation of a tendon from unspecified parts." [GOC:yaf, PMID:17567668, UBERON:0000043] is_a: BFO:0000003 is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0000043 ! results in formation of anatomical entity tendon relationship: BFO:0000050 GO:0035989 ! part of tendon development relationship: RO:0002297 UBERON:0000043 ! results in formation of anatomical entity tendon creation_date: 2011-08-30T01:35:10Z [Term] id: GO:0035993 name: deltoid tuberosity development namespace: biological_process def: "The process whose specific outcome is the progression of the deltoid tuberosity over time, from its formation to the mature structure. The deltoid tuberosity is the region on the shaft of the humerus to which the deltoid muscle attaches. The deltoid tuberosity develops through endochondral ossification in a two-phase process; an initiating tendon-dependent phase, and a muscle-dependent growth phase." [GOC:yaf, PMID:17567668, UBERON:0002498, Wikipedia:Deltoid_tuberosity] is_a: GO:0048856 ! anatomical structure development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0002498 ! results in development of deltopectoral crest relationship: BFO:0000050 GO:0060173 ! part of limb development relationship: BFO:0000050 GO:0060348 ! part of bone development relationship: RO:0002162 NCBITaxon:32523 ! in taxon Tetrapoda relationship: RO:0002296 UBERON:0002498 ! results in development of deltopectoral crest creation_date: 2011-08-30T01:46:53Z [Term] id: GO:0036022 name: limb joint morphogenesis namespace: biological_process def: "The process in which the anatomical structures of a limb joint are generated and organized. A limb joint is a flexible region that separates the rigid sections of a limb to allow movement in a controlled manner." [GOC:bf] synonym: "knee morphogenesis" NARROW [GOC:bf] synonym: "leg joint morphogenesis" NARROW [GOC:bf] is_a: BFO:0000003 is_a: GO:0009653 ! anatomical structure morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0003657 ! results in morphogenesis of limb joint relationship: BFO:0000050 GO:0035108 ! part of limb morphogenesis relationship: RO:0002298 UBERON:0003657 ! results in morphogenesis of limb joint creation_date: 2011-10-13T04:52:59Z [Term] id: GO:0036035 name: osteoclast development namespace: biological_process def: "The process whose specific outcome is the progression of a osteoclast from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate. An osteoclast is a specialized phagocytic cell associated with the absorption and removal of the mineralized matrix of bone tissue." [CL:0000092, GOC:bf, GOC:yaf] synonym: "osteoclast cell development" EXACT [GOC:bf] is_a: GO:0061515 ! myeloid cell development is_a: GO:0098751 ! bone cell development intersection_of: GO:0048468 ! cell development intersection_of: RO:0002296 CL:0000092 ! results in development of osteoclast relationship: BFO:0000050 GO:0030316 ! part of osteoclast differentiation relationship: RO:0002296 CL:0000092 ! results in development of osteoclast creation_date: 2011-11-02T05:20:35Z [Term] id: GO:0036037 name: CD8-positive, alpha-beta T cell activation namespace: biological_process def: "The change in morphology and behavior of a CD8-positive, alpha-beta T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific." [CL:0000625, GOC:yaf] is_a: GO:0046631 ! alpha-beta T cell activation intersection_of: GO:0001775 ! cell activation intersection_of: RO:0004009 CL:0000625 ! has primary input CD8-positive, alpha-beta T cell relationship: RO:0004009 CL:0000625 ! has primary input CD8-positive, alpha-beta T cell creation_date: 2011-11-03T10:34:12Z [Term] id: GO:0036053 name: glomerular endothelium fenestra namespace: cellular_component def: "A large plasma membrane-lined circular pore that perforates the flattened glomerular endothelium and, unlike those of other fenestrated capillaries, is not spanned by diaphragms; the density and size of glomerular fenestrae account, at least in part, for the high permeability of the glomerular capillary wall to water and small solutes." [GOC:cjm, MP:0011454, PMID:19129259] synonym: "GEnC fenestration" EXACT [PMID:19129259] synonym: "glomerular endothelial cell fenestration" EXACT [PMID:19129259] is_a: GO:0046930 ! pore complex property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4751 creation_date: 2011-12-12T10:53:24Z [Term] id: GO:0036064 name: ciliary basal body namespace: cellular_component def: "A membrane-tethered, short cylindrical array of microtubules and associated proteins found at the base of a eukaryotic cilium (also called flagellum) that is similar in structure to a centriole and derives from it. The cilium basal body is the site of assembly and remodeling of the cilium and serves as a nucleation site for axoneme growth. As well as anchoring the cilium, it is thought to provide a selective gateway regulating the entry of ciliary proteins and vesicles by intraflagellar transport." [GOC:cilia, GOC:clt, PMID:21750193] comment: In most eukaryotic cells, 'ciliary basal body' (GO:0036064) and 'centriole' (GO:0005814) represent a common entity that cycles through its function in cell division, then ciliogenesis, then cell division again. However, these structures are modified extensively as they transition into each other, and may contain different proteins, specific to each component. synonym: "basal body" BROAD [] synonym: "cilial basal body" EXACT [] synonym: "cilium basal body" EXACT [GOC:bf] synonym: "kinetosome" EXACT [PMID:11125699] synonym: "microtubule basal body" EXACT [] xref: NIF_Subcellular:sao11978067 is_a: GO:0005815 ! microtubule organizing center intersection_of: GO:0005815 ! microtubule organizing center intersection_of: BFO:0000050 GO:0005929 ! part of cilium relationship: BFO:0000050 GO:0005929 ! part of cilium property_value: RO:0002161 NCBITaxon:3176 property_value: RO:0002161 NCBITaxon:3378 property_value: RO:0002161 NCBITaxon:3398 property_value: RO:0002161 NCBITaxon:4890 property_value: RO:0002161 NCBITaxon:5782 creation_date: 2011-12-15T10:40:20Z [Term] id: GO:0036072 name: direct ossification namespace: biological_process def: "The formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance, that does not require the replacement of preexisting tissues." [GO_REF:0000034] is_a: GO:0001503 ! ossification creation_date: 2011-12-19T01:47:22Z [Term] id: GO:0036075 name: replacement ossification namespace: biological_process def: "Ossification that requires the replacement of a preexisting tissue prior to bone tissue formation." [GO_REF:0000034] synonym: "indirect ossification" EXACT [GO_REF:0000034] is_a: GO:0001503 ! ossification creation_date: 2011-12-19T01:53:16Z [Term] id: GO:0036093 name: germ cell proliferation namespace: biological_process def: "The multiplication or reproduction of germ cells, reproductive cells in multicellular organisms, resulting in the expansion of a cell population." [CL:0000586, GOC:kmv] is_a: BFO:0000003 is_a: GO:0008283 ! cell population proliferation intersection_of: GO:0008283 ! cell population proliferation intersection_of: RO:0012003 CL:0000586 ! acts on population of germ cell relationship: BFO:0000050 GO:0007276 ! part of gamete generation relationship: RO:0012003 CL:0000586 ! acts on population of germ cell property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4751 creation_date: 2012-01-17T04:06:27Z [Term] id: GO:0036094 name: small molecule binding namespace: molecular_function def: "Binding to a small molecule, any low molecular weight, monomeric, non-encoded molecule." [GOC:curators, GOC:pde, GOC:pm] comment: Small molecules in GO include monosaccharides but exclude disaccharides and polysaccharides. subset: goslim_agr subset: goslim_euk_cellular_processes_ribbon subset: goslim_flybase_ribbon subset: goslim_plant_ribbon subset: goslim_prokaryote_ribbon is_a: GO:0005488 ! binding creation_date: 2012-01-17T04:20:34Z [Term] id: GO:0036098 name: male germ-line stem cell population maintenance namespace: biological_process def: "The process by which an organism or tissue maintains a population of male germ-line stem cells." [GOC:sart, PMID:21752937] is_a: GO:0030718 ! germ-line stem cell population maintenance intersection_of: GO:0098727 ! maintenance of cell number intersection_of: RO:0012003 CL:0000016 ! acts on population of male germ line stem cell relationship: RO:0012003 CL:0000016 ! acts on population of male germ line stem cell property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 creation_date: 2012-01-26T01:58:10Z [Term] id: GO:0036099 name: female germ-line stem cell population maintenance namespace: biological_process def: "The process by which an organism or tissue maintains a population of female germ-line stem cells." [GOC:sart] is_a: GO:0030718 ! germ-line stem cell population maintenance intersection_of: GO:0098727 ! maintenance of cell number intersection_of: RO:0012003 CL:0000022 ! acts on population of female germ line stem cell relationship: RO:0012003 CL:0000022 ! acts on population of female germ line stem cell property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 creation_date: 2012-01-26T01:58:10Z [Term] id: GO:0036135 name: Schwann cell migration namespace: biological_process def: "The orderly movement of a Schwann cell from one site to another. A Schwann cell is a glial cell that ensheathes axons of neuron in the peripheral nervous system and is necessary for their maintenance and function." [CL:0002573, PMID:20335460] is_a: GO:0008347 ! glial cell migration intersection_of: GO:0016477 ! cell migration intersection_of: RO:0002565 CL:0002573 ! results in movement of Schwann cell relationship: RO:0002565 CL:0002573 ! results in movement of Schwann cell creation_date: 2012-03-06T10:44:39Z [Term] id: GO:0036145 name: dendritic cell homeostasis namespace: biological_process def: "The process of regulating the proliferation and elimination of dendritic cells such that the total number of dendritic cells within a whole or part of an organism is stable over time in the absence of an outside stimulus." [CL:0000451, GOC:uh, PMID:12570827, PMID:19176316] synonym: "DC homeostasis" RELATED [PMID:19176316] is_a: GO:0001776 ! leukocyte homeostasis intersection_of: GO:0048872 ! homeostasis of number of cells intersection_of: RO:0012003 CL:0000451 ! acts on population of dendritic cell relationship: RO:0012003 CL:0000451 ! acts on population of dendritic cell creation_date: 2012-03-12T11:05:36Z [Term] id: GO:0036156 name: inner dynein arm namespace: cellular_component def: "Inner arm structure present on the outer doublet microtubules of ciliary and flagellar axonemes. The structure of inner dynein arms is complex and may vary within the axoneme. Inner dynein arms are heteromeric, comprising 8 different heavy chains and various subunits. Inner and outer dynein arms have different functions in the generation of microtubule-based motility." [GOC:BHF, GOC:vk, PMID:19347929, PMID:2557057, PMID:7962092] synonym: "inner dynein arm complex" EXACT [] is_a: GO:0005858 ! axonemal dynein complex property_value: RO:0002161 NCBITaxon:3176 property_value: RO:0002161 NCBITaxon:3378 property_value: RO:0002161 NCBITaxon:3398 property_value: RO:0002161 NCBITaxon:4890 property_value: RO:0002161 NCBITaxon:5782 creation_date: 2012-03-21T01:24:54Z [Term] id: GO:0036157 name: outer dynein arm namespace: cellular_component def: "Outer arm structure present on the outer doublet microtubules of ciliary and flagellar axonemes. Outer dynein arms contain 2-3 heavy chains, two or more intermediate chains and a cluster of 4-8 light chains. Inner and outer dynein arms have different functions in the generation of microtubule-based motility." [GOC:BHF, GOC:vk, PMID:2557057, PMID:6218174] synonym: "outer dynein arm complex" EXACT [] is_a: GO:0005858 ! axonemal dynein complex property_value: RO:0002161 NCBITaxon:3176 property_value: RO:0002161 NCBITaxon:3378 property_value: RO:0002161 NCBITaxon:3398 property_value: RO:0002161 NCBITaxon:4890 property_value: RO:0002161 NCBITaxon:5782 creation_date: 2012-03-21T01:25:03Z [Term] id: GO:0036158 name: outer dynein arm assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form an axonemal dynein outer arm, an outer arm structure present on the outer doublet microtubules of ciliary and flagellar axonemes." [GOC:BHF, GOC:vk, PMID:19944400] synonym: "ODA assembly" EXACT [PMID:19944400] is_a: GO:0070286 ! axonemal dynein complex assembly intersection_of: GO:0022607 ! cellular component assembly intersection_of: RO:0002588 GO:0036157 ! results in assembly of outer dynein arm relationship: RO:0002588 GO:0036157 ! results in assembly of outer dynein arm property_value: RO:0002161 NCBITaxon:3176 property_value: RO:0002161 NCBITaxon:3378 property_value: RO:0002161 NCBITaxon:3398 property_value: RO:0002161 NCBITaxon:4890 property_value: RO:0002161 NCBITaxon:5782 creation_date: 2012-03-21T02:25:01Z [Term] id: GO:0036159 name: inner dynein arm assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form an axonemal dynein inner arm, an inner arm structure present on the outer doublet microtubules of ciliary and flagellar axonemes." [GOC:BHF, GOC:vk, PMID:19944400] synonym: "IDA assembly" EXACT [PMID:19944400] is_a: GO:0070286 ! axonemal dynein complex assembly intersection_of: GO:0022607 ! cellular component assembly intersection_of: RO:0002588 GO:0036156 ! results in assembly of inner dynein arm relationship: RO:0002588 GO:0036156 ! results in assembly of inner dynein arm property_value: RO:0002161 NCBITaxon:3176 property_value: RO:0002161 NCBITaxon:3378 property_value: RO:0002161 NCBITaxon:3398 property_value: RO:0002161 NCBITaxon:4890 property_value: RO:0002161 NCBITaxon:5782 creation_date: 2012-03-21T02:25:01Z [Term] id: GO:0036160 name: melanocyte-stimulating hormone secretion namespace: biological_process def: "The regulated release of a melanocyte-stimulating hormone, any of a group of peptide hormones that are produced by cells in the intermediate lobe of the pituitary gland, and stimulate the production of melanin to increase pigmentation." [GOC:cjm, Wikipedia:Melanocyte-stimulating_hormone] synonym: "MSH secretion" EXACT [GOC:cjm] is_a: GO:0030072 ! peptide hormone secretion creation_date: 2012-03-26T01:16:55Z [Term] id: GO:0036161 name: calcitonin secretion namespace: biological_process def: "The regulated release of calcitonin, a peptide hormone that participates in calcium and phosphorus metabolism, from a cell." [GOC:cjm] is_a: GO:0030072 ! peptide hormone secretion intersection_of: GO:0046903 ! secretion intersection_of: RO:0004009 CHEBI:3306 ! has primary input relationship: RO:0004009 CHEBI:3306 ! has primary input creation_date: 2012-03-26T01:30:32Z [Term] id: GO:0036162 name: oxytocin production namespace: biological_process def: "The appearance of oxytocin, a cyclic nonapeptide hormone with amino acid sequence CYIQNCPLG, due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. Oxytocin is the principal uterine-contracting and milk-ejecting hormone of the posterior pituitary, and together with the neuropeptide vasopressin, is believed to influence social cognition and behavior. It also acts as a neurotransmitter in the brain." [GOC:cjm, Wikipedia:Oxytocin] comment: Note that this term is intended for use when a gene product is seen to cause apparent increases in intracellular or extracellular oxytocin levels, without specific regard as to whether the increase is due to increased biosynthesis, increased secretion of preexisting oxytocin molecules, or increased conversion from precursor molecules. synonym: "oxytocin biosynthesis" NARROW [] synonym: "oxytocin secretion" NARROW [] is_a: GO:0010467 ! gene expression relationship: BFO:0000051 GO:0030072 ! has part peptide hormone secretion property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/21535" xsd:anyURI property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/9542" xsd:anyURI creation_date: 2012-03-26T01:43:46Z [Term] id: GO:0036179 name: osteoclast maturation namespace: biological_process def: "A developmental process, independent of morphogenetic (shape) change, that is required for an osteoclast cell to attain its fully functional state. An osteoclast is a specialized phagocytic cell associated with the absorption and removal of the mineralized matrix of bone tissue, and which typically differentiates from monocytes." [CL:0000092, GOC:pg] synonym: "chondroclast maturation" RELATED [CL:0000092] is_a: GO:0048469 ! cell maturation intersection_of: GO:0021700 ! developmental maturation intersection_of: RO:0002299 CL:0000092 ! results in maturation of osteoclast relationship: BFO:0000050 GO:0036035 ! part of osteoclast development relationship: RO:0002299 CL:0000092 ! results in maturation of osteoclast creation_date: 2012-03-29T02:04:00Z [Term] id: GO:0036194 name: muscle cell projection namespace: cellular_component def: "A prolongation or process extending from a muscle cell. A muscle cell is a mature contractile cell, commonly known as a myocyte. This cell has as part of its cytoplasm myofibrils organized in various patterns." [CL:0000187, GOC:kmv, PMID:15930100, PMID:22464329] synonym: "muscle arm" NARROW [GOC:kmv] synonym: "myocyte projection" EXACT [CL:0000187] synonym: "myopodia" NARROW [GOC:kmv] is_a: GO:0120025 ! plasma membrane bounded cell projection intersection_of: GO:0120025 ! plasma membrane bounded cell projection intersection_of: BFO:0000050 CL:0000187 ! part of muscle cell relationship: BFO:0000050 CL:0000187 ! part of muscle cell creation_date: 2012-04-20T10:20:47Z [Term] id: GO:0036195 name: muscle cell projection membrane namespace: cellular_component def: "The portion of the plasma membrane surrounding a muscle cell projection." [CL:0000187, GOC:kmv, PMID:15930100, PMID:22464329] is_a: GO:0031253 ! cell projection membrane intersection_of: GO:0031253 ! cell projection membrane intersection_of: BFO:0000050 GO:0036194 ! part of muscle cell projection relationship: BFO:0000050 GO:0036194 ! part of muscle cell projection creation_date: 2012-04-20T10:21:51Z [Term] id: GO:0036211 name: protein modification process namespace: biological_process def: "The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications). Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification)." [GOC:bf, GOC:jl] subset: gocheck_do_not_annotate subset: goslim_candida subset: goslim_chembl subset: goslim_pir subset: goslim_plant subset: goslim_prokaryote synonym: "cellular protein modification process" EXACT [] synonym: "process resulting in protein modification" EXACT [] synonym: "protein modification" EXACT [GOC:bf] is_a: GO:0019538 ! protein metabolic process is_a: GO:0043412 ! macromolecule modification property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/23112" xsd:anyURI creation_date: 2012-04-26T01:47:12Z [Term] id: GO:0036230 name: granulocyte activation namespace: biological_process def: "The change in morphology and behavior of a granulocyte resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor." [CL:0000094, GOC:nhn] is_a: GO:0002274 ! myeloid leukocyte activation intersection_of: GO:0001775 ! cell activation intersection_of: RO:0004009 CL:0000094 ! has primary input granulocyte relationship: RO:0004009 CL:0000094 ! has primary input granulocyte creation_date: 2012-05-11T10:57:48Z [Term] id: GO:0036293 name: response to decreased oxygen levels namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting a decline in the level of oxygen." [GOC:al] comment: This term should be used when a decrease in oxygen levels is not considered a stress response. For a hypoxic stress response, consider instead 'response to hypoxia ; GO:0001666'. synonym: "response to lowered oxygen levels" EXACT [GOC:bf] is_a: GO:0070482 ! response to oxygen levels creation_date: 2012-07-20T01:05:46Z [Term] id: GO:0036303 name: lymph vessel morphogenesis namespace: biological_process def: "The process in which the anatomical structures of lymph vessels are generated and organized. The lymph vessel is the vasculature carrying lymph." [GOC:BHF, GOC:gr, PMID:18093989] is_a: BFO:0000003 is_a: GO:0009653 ! anatomical structure morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0001473 ! results in morphogenesis of lymphatic vessel relationship: BFO:0000050 GO:0001945 ! part of lymph vessel development relationship: RO:0002298 UBERON:0001473 ! results in morphogenesis of lymphatic vessel creation_date: 2012-08-08T10:08:47Z [Term] id: GO:0036304 name: umbilical cord morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the umbilical cord are generated and organized. The umbilical cord is an organ or embryonic origin consisting of the 2 umbilical arteries and the one umbilical vein. The umbilical cord connects the cardiovascular system of the fetus to the mother via the placenta." [GOC:BHF, GOC:gr, PMID:15107403] is_a: BFO:0000003 is_a: GO:0009653 ! anatomical structure morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0002331 ! results in morphogenesis of umbilical cord relationship: BFO:0000050 GO:0061027 ! part of umbilical cord development relationship: RO:0002298 UBERON:0002331 ! results in morphogenesis of umbilical cord creation_date: 2012-08-08T10:12:11Z [Term] id: GO:0036305 name: ameloblast differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of an ameloblast, a cylindrical epithelial cell in the innermost layer of the enamel organ." [CL:0000059] is_a: GO:0002065 ! columnar/cuboidal epithelial cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000059 ! results in acquisition of features of ameloblast relationship: RO:0002315 CL:0000059 ! results in acquisition of features of ameloblast property_value: RO:0002161 NCBITaxon:8782 creation_date: 2012-08-08T13:49:15Z [Term] id: GO:0036321 name: ghrelin secretion namespace: biological_process def: "The regulated release of ghrelin from a cell. Ghrelin is a 28 amino acid hunger-stimulating peptide hormone." [GOC:cjm, PMID:14610293, Wikipedia:Ghrelin] synonym: "pancreatic ghrelin secretion" NARROW [GOC:cjm] is_a: GO:0030072 ! peptide hormone secretion intersection_of: GO:0046903 ! secretion intersection_of: RO:0004009 CHEBI:75431 ! has primary input relationship: RO:0004009 CHEBI:75431 ! has primary input creation_date: 2012-09-04T14:16:43Z [Term] id: GO:0036322 name: pancreatic polypeptide secretion namespace: biological_process def: "The regulated release of pancreatic polypeptide (PP) from a cell. Pancreatic polypeptide is a 36 amino acid polypeptide secreted by islets of Langerhans cells in the pancreas." [GOC:cjm, PMID:12730894, Wikipedia:Pancreatic_polypeptide] synonym: "PP secretion" NARROW [GOC:cjm] is_a: GO:0030072 ! peptide hormone secretion creation_date: 2012-09-04T14:39:03Z [Term] id: GO:0036333 name: hepatocyte homeostasis namespace: biological_process def: "Any biological process involved in the maintenance of the steady-state number of hepatocytes within a population of cells. Hepatocytes are specialized epithelial cells of the liver that are organized into interconnected plates called lobules." [CL:0000182, GOC:nhn, PMID:19878874] is_a: BFO:0000003 is_a: GO:0048872 ! homeostasis of number of cells intersection_of: GO:0048872 ! homeostasis of number of cells intersection_of: RO:0012003 CL:0000182 ! acts on population of hepatocyte relationship: RO:0012003 CL:0000182 ! acts on population of hepatocyte property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 creation_date: 2012-09-05T10:17:07Z [Term] id: GO:0036334 name: epidermal stem cell homeostasis namespace: biological_process def: "Any biological process involved in the maintenance of the steady-state number of epidermal stem cells within a population of cells." [CL:1000428, GOC:nhn, PMID:17666529] is_a: BFO:0000003 is_a: GO:0048872 ! homeostasis of number of cells intersection_of: GO:0048872 ! homeostasis of number of cells intersection_of: RO:0012003 CL:1000428 ! acts on population of stem cell of epidermis relationship: RO:0012003 CL:1000428 ! acts on population of stem cell of epidermis property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 creation_date: 2012-09-05T10:21:23Z [Term] id: GO:0036336 name: dendritic cell migration namespace: biological_process def: "The movement of a dendritic cell within or between different tissues and organs of the body." [CL:0000451, GOC:nhn, PMID:19339990] is_a: GO:0071674 ! mononuclear cell migration intersection_of: GO:0016477 ! cell migration intersection_of: RO:0002565 CL:0000451 ! results in movement of dendritic cell relationship: RO:0002565 CL:0000451 ! results in movement of dendritic cell creation_date: 2012-09-05T10:24:46Z [Term] id: GO:0036342 name: post-anal tail morphogenesis namespace: biological_process def: "The process in which a post-anal tail is generated and organized. A post-anal tail is a muscular region of the body that extends posterior to the anus. The post-anal tail may aid locomotion and balance." [GOC:bf, GOC:kmv, Wikipedia:Chordate] is_a: BFO:0000003 is_a: GO:0009653 ! anatomical structure morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0007812 ! results in morphogenesis of post-anal tail relationship: RO:0002298 UBERON:0007812 ! results in morphogenesis of post-anal tail creation_date: 2012-09-11T13:54:49Z [Term] id: GO:0036344 name: platelet morphogenesis namespace: biological_process def: "Generation and organization of a platelet, a non-nucleated disk-shaped cell formed by extrusion from megakaryocytes, found in the blood of all mammals, and mainly involved in blood coagulation." [CL:0000233, GOC:BHF, GOC:vk] is_a: GO:0000902 ! cell morphogenesis creation_date: 2012-09-11T15:15:35Z [Term] id: GO:0036345 name: platelet maturation namespace: biological_process def: "A developmental process, independent of morphogenetic (shape) change, that is required for a platelet to attain its fully functional state. A platelet is a non-nucleated disk-shaped cell formed by extrusion from megakaryocytes, found in the blood of all mammals, and mainly involved in blood coagulation." [CL:0000233, GOC:BHF, GOC:vk] is_a: GO:0048469 ! cell maturation intersection_of: GO:0021700 ! developmental maturation intersection_of: RO:0002299 CL:0000233 ! results in maturation of platelet relationship: RO:0002299 CL:0000233 ! results in maturation of platelet creation_date: 2012-09-11T15:23:11Z [Term] id: GO:0036376 name: sodium ion export across plasma membrane namespace: biological_process def: "The directed movement of sodium ions from inside of a cell, across the plasma membrane and into the extracellular region." [GOC:vw, PMID:14674689] synonym: "sodium export" RELATED [GOC:mah] synonym: "sodium ion export" RELATED [] synonym: "sodium ion export from cell" EXACT [] is_a: GO:0035725 ! sodium ion transmembrane transport is_a: GO:0140115 ! export across plasma membrane intersection_of: GO:0006810 ! transport intersection_of: RO:0002338 GO:0005829 ! has target start location cytosol intersection_of: RO:0002339 GO:0005576 ! has target end location extracellular region intersection_of: RO:0002342 GO:0005886 ! results in transport across plasma membrane intersection_of: RO:0004009 CHEBI:29101 ! has primary input creation_date: 2009-12-16T11:13:55Z [Term] id: GO:0036379 name: myofilament namespace: cellular_component def: "Any of the smallest contractile units of a myofibril (striated muscle fiber)." [Wikipedia:Myofilament] synonym: "striated muscle filament" EXACT [GOC:bf] is_a: GO:0110165 ! cellular anatomical structure relationship: BFO:0000050 GO:0030016 ! part of myofibril creation_date: 2013-05-22T14:39:06Z [Term] id: GO:0036444 name: calcium import into the mitochondrion namespace: biological_process def: "A process in which a calcium ion (Ca2+) is transported from the cytosol into the mitochondrial matrix." [GOC:vw] synonym: "calcium ion import into mitochondrion" BROAD [] synonym: "calcium ion transmembrane import into mitochondrion" EXACT [] synonym: "mitochondrial calcium ion import" BROAD [GOC:vw] synonym: "mitochondrial calcium uptake" EXACT [] is_a: GO:0006851 ! mitochondrial calcium ion transmembrane transport intersection_of: GO:0006810 ! transport intersection_of: RO:0002338 GO:0005829 ! has target start location cytosol intersection_of: RO:0002339 GO:0005759 ! has target end location mitochondrial matrix intersection_of: RO:0002342 GO:0031966 ! results in transport across mitochondrial membrane intersection_of: RO:0004009 CHEBI:29108 ! has primary input relationship: RO:0002338 GO:0005829 ! has target start location cytosol relationship: RO:0002339 GO:0005759 ! has target end location mitochondrial matrix creation_date: 2013-10-28T09:32:39Z [Term] id: GO:0036446 name: myofibroblast differentiation namespace: biological_process def: "The process in which an undifferentiated cell acquires the features of a myofibroblast cell." [CL:0000186, GOC:nhn] synonym: "myofibroblast cell differentiation" EXACT [CL:0000186] is_a: GO:0030154 ! cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000186 ! results in acquisition of features of myofibroblast cell relationship: RO:0002315 CL:0000186 ! results in acquisition of features of myofibroblast cell creation_date: 2013-10-30T10:06:51Z [Term] id: GO:0036457 name: keratohyalin granule namespace: cellular_component def: "A cytoplasmic, non-membrane bound granule of, at least, keratinocyte. Associated to keratin intermediate filaments and partially crosslinked to the cell envelope." [GOC:krc, PMID:15854042] is_a: GO:0110165 ! cellular anatomical structure relationship: BFO:0000050 GO:0005737 ! part of cytoplasm relationship: RO:0002162 NCBITaxon:6072 ! in taxon Eumetazoa creation_date: 2013-12-09T13:04:09Z [Term] id: GO:0036477 name: somatodendritic compartment namespace: cellular_component def: "The region of a neuron that includes the cell body (cell soma) and dendrite(s), but excludes the axon." [GOC:pad, GOC:PARL] is_a: GO:0110165 ! cellular anatomical structure relationship: BFO:0000050 CL:0000540 ! part of neuron relationship: RO:0002162 NCBITaxon:6072 ! in taxon Eumetazoa property_value: skos:prefLabel "somatodendritic compartment" xsd:string creation_date: 2014-07-24T10:06:19Z [Term] id: GO:0036484 name: trunk neural crest cell migration namespace: biological_process def: "The characteristic movement of trunk neural crest cells from the neural tube to other locations in the vertebrate embryo." [GOC:bf, GOC:mat, GOC:PARL, PMID:2387238] synonym: "trunk NCC migration" EXACT [PMID:2387238] is_a: GO:0001755 ! neural crest cell migration intersection_of: GO:0016477 ! cell migration intersection_of: RO:0002565 CL:0000011 ! results in movement of migratory trunk neural crest cell relationship: BFO:0000050 GO:0035290 ! part of trunk segmentation relationship: RO:0002565 CL:0000011 ! results in movement of migratory trunk neural crest cell creation_date: 2014-08-26T15:27:44Z [Term] id: GO:0036504 name: Golgi membrane fusion namespace: biological_process def: "The joining of two lipid bilayers that surround the Golgi apparatus to form a single Golgi membrane." [GOC:bf, GOC:PARL, PMID:12473691] synonym: "Golgi apparatus membrane fusion" EXACT [] synonym: "membrane fusion involved in Golgi reassembly" EXACT [GOC:bf] synonym: "post-mitotic fusion of Golgi membranes" EXACT [PMID:10811609] is_a: GO:0090174 ! organelle membrane fusion intersection_of: GO:0061025 ! membrane fusion intersection_of: RO:0012008 GO:0000139 ! results in fusion of Golgi membrane relationship: BFO:0000050 GO:0090168 ! part of Golgi reassembly relationship: RO:0012008 GO:0000139 ! results in fusion of Golgi membrane creation_date: 2015-05-21T10:05:06Z [Term] id: GO:0036520 name: astrocyte-dopaminergic neuron signaling namespace: biological_process def: "Cell-cell signaling that mediates the transfer of information from an astrocyte to a dopaminergic neuron." [GOC:bf, GOC:PARL, PMID:12794311, PMID:21752258] synonym: "astrocyte-dopaminergic neuron cell signaling" EXACT [GOC:bf] synonym: "dopaminergic neuron-astrocyte crosstalk" RELATED [PMID:21752258] synonym: "mesencephalic dopaminergic neuron-astrocyte crosstalk" NARROW [PMID:21752258] synonym: "midbrain dopaminergic neuron-astrocyte crosstalk" NARROW [PMID:21752258] is_a: GO:0150098 ! glial cell-neuron signaling intersection_of: GO:0007267 ! cell-cell signaling intersection_of: RO:0002231 CL:0000127 ! has start location astrocyte intersection_of: RO:0002232 CL:0000700 ! has end location dopaminergic neuron relationship: RO:0002231 CL:0000127 ! has start location astrocyte relationship: RO:0002232 CL:0000700 ! has end location dopaminergic neuron creation_date: 2016-02-29T14:05:47Z [Term] id: GO:0038023 name: signaling receptor activity namespace: molecular_function def: "Receiving a signal and transmitting it in the cell to initiate a change in cell activity. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response." [GOC:bf, GOC:signaling] subset: goslim_agr subset: goslim_chembl subset: goslim_drosophila subset: goslim_flybase_ribbon subset: goslim_metagenomics subset: goslim_mouse subset: goslim_pir subset: goslim_plant subset: goslim_plant_ribbon synonym: "receptor activity" BROAD [] synonym: "receptor activity involved in signal transduction" EXACT [GOC:bf] synonym: "signalling receptor activity" EXACT [] is_a: GO:0060089 ! molecular transducer activity creation_date: 2011-08-01T02:45:27Z [Term] id: GO:0038024 name: cargo receptor activity namespace: molecular_function def: "Binding specifically to a substance (cargo) to deliver it to a transport vesicle. Cargo receptors span membranes (for instance the plasma membrane or the endoplasmic reticulum membrane), binding simultaneously to cargo molecules and coat adaptors, to efficiently recruit the cargo molecules to nascent vesicles." [PMID:15239958, PMID:27903609] comment: Notes: (1) For receptors binding a molecule but coupled to a signal transduction pathway, consider instead the term 'signaling receptor activity ; GO:0038023' and its children. (2) Cargo receptors transport substances by vesicular transport, not by transmembrane transport. For transmembrane transporters, consider instead the term 'transmembrane transporter activity ; GO:0022857'. subset: goslim_drosophila subset: goslim_generic synonym: "endocytic receptor activity" NARROW [GOC:signaling, ISBN:0123645387, PMID:12671190] synonym: "receptor activity" BROAD [] synonym: "receptor activity involved in receptor-mediated endocytosis" NARROW [GOC:bf] synonym: "transport receptor activity" BROAD [GOC:signaling] xref: Reactome:R-HSA-203716 "eNOS:Caveolin-1 complex binds to Nostrin" xref: Reactome:R-HSA-2160915 "Receptor-mediated uptake of HA" xref: Reactome:R-HSA-3000103 "CUBN:AMN binds CBLIF:RCbl" xref: Reactome:R-HSA-3000112 "CD320-mediated TCN2:RCbl uptake and delivery to lysosome" xref: Reactome:R-HSA-3000122 "CD320 binds extracellular TCN2:RCbl" xref: Reactome:R-HSA-3000137 "CUBN:AMN-mediated CBLIF:RCbl uptake and delivery to lysosome" xref: Reactome:R-HSA-350168 "LRP2-mediated uptake of extracellular CUBN:GC:25(OH)D" xref: Reactome:R-HSA-350186 "CUBN binds GC:25(OH)D" xref: Reactome:R-HSA-9759202 "LRP2-mediated TCN2:RCbl uptake and delivery to lysosome" xref: Reactome:R-HSA-9759209 "LRP2 binds extracellular TCN2:RCbl" is_a: GO:0003674 ! molecular_function relationship: BFO:0000050 GO:0016192 ! part of vesicle-mediated transport relationship: BFO:0000051 GO:0060090 ! has part molecular adaptor activity property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/26872" xsd:anyURI property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/30576" xsd:anyURI creation_date: 2011-08-01T02:50:45Z [Term] id: GO:0038161 name: prolactin signaling pathway namespace: biological_process def: "The series of molecular signals initiated by the binding of the peptide hormone prolactin to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:nhn, GOC:signaling, PMID:21664429] synonym: "PRL signaling pathway" EXACT [PMID:21664429, PR:000013246] synonym: "prolactin-mediated signaling pathway" EXACT [GOC:bf] is_a: GO:0009755 ! hormone-mediated signaling pathway is_a: GO:0019221 ! cytokine-mediated signaling pathway property_value: RO:0002161 NCBITaxon:4751 creation_date: 2012-05-14T01:52:59Z [Term] id: GO:0038169 name: somatostatin receptor signaling pathway namespace: biological_process def: "A G protein-coupled receptor signaling pathway initiated by somatostatin binding to the somatostatin receptor (SSTR) on the surface of a target cell, and ending with the regulation of a downstream cellular process." [GOC:jc, PMID:18006219, PMID:8769369] comment: In addition to somatostatin (SST), the somatostatin receptors (SSTRs) can also be activated by the agonist cortistatin (CST). For signal transduction specifically initiated by the ligand somatostatin, consider instead annotating to the child term 'somatostatin signaling pathway ; GO:0038170'. synonym: "SST receptor signaling pathway" EXACT [GOC:bf] synonym: "SSTR signaling pathway" RELATED [GOC:bf] is_a: GO:0007186 ! G protein-coupled receptor signaling pathway creation_date: 2012-06-12T10:30:01Z [Term] id: GO:0038170 name: somatostatin signaling pathway namespace: biological_process def: "A G protein-coupled receptor signaling pathway initiated by somatostatin binding to a somatostatin receptor (SSTR), and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:bf, GOC:nhn, GOC:signaling, PMID:18006219, Wikipedia:Somatostatin] synonym: "somatostatin signalling pathway" EXACT [GOC:bf] synonym: "somatostatin-activated somatostatin receptor signaling pathway" EXACT [GOC:bf] synonym: "somatostatin-mediated signaling pathway" EXACT [GOC:bf] synonym: "somatotrophin release inhibiting factor signaling pathway" EXACT [Wikipedia:Somatostatin] synonym: "SRIF signaling pathway" EXACT [Wikipedia:Somatostatin] synonym: "SST signaling pathway" EXACT [Wikipedia:Somatostatin] is_a: GO:0009755 ! hormone-mediated signaling pathway is_a: GO:0038169 ! somatostatin receptor signaling pathway relationship: RO:0004009 CHEBI:64628 ! has primary input property_value: RO:0002161 NCBITaxon:4751 creation_date: 2012-06-12T10:33:21Z [Term] id: GO:0038187 name: pattern recognition receptor activity namespace: molecular_function def: "Combining with a pathogen-associated molecular pattern (PAMP), a structure conserved among microbial species to initiate an innate immune response." [GOC:ar, GOC:bf] synonym: "macrophage receptor activity" RELATED [] synonym: "MAMP receptor activity" NARROW [] synonym: "microbe-associated molecular pattern receptor activity" NARROW [] synonym: "PAMP receptor activity" NARROW [] synonym: "pathogen associated molecular pattern receptor activity" NARROW [] synonym: "PRR" EXACT [] synonym: "PRR activity" EXACT [Wikipedia:Pattern_recognition_receptor] synonym: "signaling pattern recognition receptor activity" RELATED [] xref: Wikipedia:Pattern_recognition_receptor is_a: GO:0038023 ! signaling receptor activity property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/17995" xsd:anyURI property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/18588" xsd:anyURI creation_date: 2013-05-29T15:24:44Z [Term] id: GO:0038188 name: cholecystokinin signaling pathway namespace: biological_process def: "A G protein-coupled receptor signaling pathway initiated by cholecystokinin binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:jc, PMID:11181948] synonym: "CCK signaling" EXACT [PMID:11181948, Wikipedia:Cholecystokinin] synonym: "cholecystokinin receptor signaling pathway" RELATED [GOC:bf] xref: Wikipedia:Cholecystokinin is_a: GO:0007186 ! G protein-coupled receptor signaling pathway creation_date: 2013-07-01T13:05:46Z [Term] id: GO:0039006 name: pronephric nephron tubule formation namespace: biological_process def: "The developmental process pertaining to the initial formation of a pronephric nephron tubule from unspecified parts. A pronephric nephron tubule is an epithelial tube that is part of a nephron in the pronephros." [GOC:mtg_kidney_jan10] synonym: "pronephric tubule formation" EXACT [GOC:mtg_kidney_jan10] synonym: "pronephros tubule formation" EXACT [GOC:mtg_kidney_jan10] is_a: GO:0072079 ! nephron tubule formation intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0005310 ! results in formation of anatomical entity pronephric nephron tubule relationship: BFO:0000050 GO:0039008 ! part of pronephric nephron tubule morphogenesis relationship: BFO:0000050 GO:0072116 ! part of pronephros formation relationship: RO:0002297 UBERON:0005310 ! results in formation of anatomical entity pronephric nephron tubule creation_date: 2010-07-02T09:37:27Z [Term] id: GO:0039007 name: pronephric nephron morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the pronephric nephron are generated and organized. A pronephric nephron is the functional unit of the pronephros." [GOC:mtg_kidney_jan10] is_a: GO:0072028 ! nephron morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0005309 ! results in morphogenesis of pronephric nephron relationship: BFO:0000050 GO:0039019 ! part of pronephric nephron development relationship: BFO:0000050 GO:0072114 ! part of pronephros morphogenesis relationship: RO:0002298 UBERON:0005309 ! results in morphogenesis of pronephric nephron creation_date: 2010-07-02T09:38:53Z [Term] id: GO:0039008 name: pronephric nephron tubule morphogenesis namespace: biological_process def: "The process in which the anatomical structures of a pronephric nephron tubule are generated and organized from an epithelium. A pronephric nephron tubule is an epithelial tube that is part of the pronephric nephron." [GOC:mtg_kidney_jan10, ZFA:00001558] is_a: GO:0072078 ! nephron tubule morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0005310 ! results in morphogenesis of pronephric nephron tubule relationship: BFO:0000050 GO:0039007 ! part of pronephric nephron morphogenesis relationship: BFO:0000050 GO:0039020 ! part of pronephric nephron tubule development relationship: RO:0002298 UBERON:0005310 ! results in morphogenesis of pronephric nephron tubule creation_date: 2010-07-02T09:45:55Z [Term] id: GO:0039011 name: pronephric proximal tubule morphogenesis namespace: biological_process def: "The process in which the anatomical structures of a pronephric nephron proximal tubule are generated and organized. A pronephric nephron tubule is an epithelial tube that is part of the pronephros." [GOC:mtg_kidney_jan10] synonym: "pronephros proximal tubule morphogenesis" EXACT [GOC:mtg_kidney_jan10] is_a: GO:0039008 ! pronephric nephron tubule morphogenesis is_a: GO:0072158 ! proximal tubule morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0006173 ! results in morphogenesis of pronephric proximal tubule relationship: BFO:0000050 GO:0035776 ! part of pronephric proximal tubule development relationship: RO:0002298 UBERON:0006173 ! results in morphogenesis of pronephric proximal tubule creation_date: 2010-07-02T09:53:12Z [Term] id: GO:0039013 name: pronephric distal tubule morphogenesis namespace: biological_process def: "The process in which the anatomical structures of a pronephric nephron distal tubule are generated and organized. A pronephric nephron tubule is an epithelial tube that is part of the pronephros." [GOC:mtg_kidney_jan10] is_a: GO:0039008 ! pronephric nephron tubule morphogenesis is_a: GO:0072156 ! distal tubule morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0006175 ! results in morphogenesis of pronephric distal tubule relationship: BFO:0000050 GO:0035777 ! part of pronephric distal tubule development relationship: RO:0002298 UBERON:0006175 ! results in morphogenesis of pronephric distal tubule creation_date: 2010-07-02T09:58:03Z [Term] id: GO:0039014 name: cell differentiation involved in pronephros development namespace: biological_process def: "The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the cells of the pronephros as it progresses from its formation to the mature state." [GOC:mtg_kidney_jan10] synonym: "cell differentiation involved in pronephric kidney development" EXACT [GOC:mtg_kidney_jan10] is_a: GO:0061005 ! cell differentiation involved in kidney development intersection_of: GO:0030154 ! cell differentiation intersection_of: BFO:0000050 GO:0048793 ! part of pronephros development relationship: BFO:0000050 GO:0048793 ! part of pronephros development creation_date: 2010-07-02T09:59:25Z [Term] id: GO:0039015 name: cell proliferation involved in pronephros development namespace: biological_process def: "The multiplication or reproduction of cells, resulting in the expansion of the population in the pronephros." [GOC:mtg_kidney_jan10] synonym: "cell proliferation involved in pronephric kidney development" EXACT [GOC:mtg_kidney_jan10] is_a: GO:0072111 ! cell proliferation involved in kidney development intersection_of: GO:0008283 ! cell population proliferation intersection_of: BFO:0000050 GO:0048793 ! part of pronephros development relationship: BFO:0000050 GO:0048793 ! part of pronephros development creation_date: 2010-07-02T10:01:49Z [Term] id: GO:0039016 name: cell-cell signaling involved in pronephros development namespace: biological_process def: "Any process that mediates the transfer of information from one cell to another and contributes to the progression of the pronephros over time, from its formation to the mature organ." [GOC:mtg_kidney_jan10] synonym: "cell-cell signaling involved in pronephric kidney development" EXACT [GOC:mtg_kidney_jan10] synonym: "cell-cell signalling involved in pronephros development" EXACT [GOC:mah] is_a: GO:0060995 ! cell-cell signaling involved in kidney development intersection_of: GO:0007267 ! cell-cell signaling intersection_of: BFO:0000050 GO:0048793 ! part of pronephros development relationship: BFO:0000050 GO:0048793 ! part of pronephros development creation_date: 2010-07-02T10:03:16Z [Term] id: GO:0039017 name: pattern specification involved in pronephros development namespace: biological_process def: "Any developmental process that results in the creation of defined areas or spaces within the pronephros to which cells respond and eventually are instructed to differentiate." [GOC:mtg_kidney_jan10] synonym: "pattern specification involved in pronephric kidney development" EXACT [GOC:mtg_kidney_jan10] is_a: GO:0061004 ! pattern specification involved in kidney development intersection_of: GO:0007389 ! pattern specification process intersection_of: BFO:0000050 GO:0048793 ! part of pronephros development relationship: BFO:0000050 GO:0048793 ! part of pronephros development creation_date: 2010-07-02T10:04:39Z [Term] id: GO:0039019 name: pronephric nephron development namespace: biological_process def: "The process whose specific outcome is the progression of the pronephric nephron over time, from its formation to the mature structure. A pronephric nephron is the functional unit of the pronephros." [GOC:mtg_kidney_jan10, XAO:00002785] is_a: GO:0072006 ! nephron development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0005309 ! results in development of pronephric nephron relationship: BFO:0000050 GO:0048793 ! part of pronephros development relationship: RO:0002296 UBERON:0005309 ! results in development of pronephric nephron creation_date: 2010-07-02T10:10:20Z [Term] id: GO:0039020 name: pronephric nephron tubule development namespace: biological_process def: "The process whose specific outcome is the progression of a pronephric nephron tubule over time, from its formation to the mature structure. The pronephric nephron tubule is an epithelial tube that is part of the pronephric nephron and connects the filtration unit (glomerulus or glomus) of the pronephros to the pronephric duct." [GOC:mtg_kidney_jan10, PMID:19909807, PMID:9268568] is_a: GO:0072080 ! nephron tubule development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0005310 ! results in development of pronephric nephron tubule relationship: BFO:0000050 GO:0039019 ! part of pronephric nephron development relationship: RO:0002296 UBERON:0005310 ! results in development of pronephric nephron tubule creation_date: 2010-07-02T10:11:36Z [Term] id: GO:0039021 name: pronephric glomerulus development namespace: biological_process def: "The progression of the glomerulus of the pronephric kidney over time from its initial formation until its mature state. The pronephric glomerulus is part of the pronephric nephron and is restricted to one body segment." [GOC:dgh, GOC:mtg_kidney_jan10, ZFA:00001557] comment: This term is intended for annotation of fish and other organisms which contain a glomerulus as part of the pronephric nephron. It should not be used for annotation of Xenopus, which contains a pronephric glomus rather than a glomerulus. is_a: GO:0032835 ! glomerulus development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0004739 ! results in development of pronephric glomerulus relationship: BFO:0000050 GO:0039019 ! part of pronephric nephron development relationship: RO:0002296 UBERON:0004739 ! results in development of pronephric glomerulus creation_date: 2010-07-02T10:13:38Z [Term] id: GO:0039022 name: pronephric duct development namespace: biological_process def: "The process whose specific outcome is the progression of the pronephric duct over time, from its formation to the mature structure. The pronephric duct collects the filtrate from the pronephric tubules and opens to the exterior of the pronephric kidney." [GOC:mtg_kidney_jan10, PMID:15647339, XAO:0000063, ZFA:0000150] is_a: GO:0072176 ! nephric duct development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0003060 ! results in development of pronephric duct relationship: BFO:0000050 GO:0048793 ! part of pronephros development relationship: RO:0002296 UBERON:0003060 ! results in development of pronephric duct creation_date: 2010-07-02T10:15:03Z [Term] id: GO:0039023 name: pronephric duct morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the pronephric duct are generated and organized. The pronephric duct collects the filtrate from the pronephric tubules and opens to the exterior of the kidney." [GOC:mtg_kidney_jan10, XAO:0000063, ZFA:0000150] is_a: GO:0072178 ! nephric duct morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0003060 ! results in morphogenesis of pronephric duct relationship: BFO:0000050 GO:0039022 ! part of pronephric duct development relationship: BFO:0000050 GO:0072114 ! part of pronephros morphogenesis relationship: RO:0002298 UBERON:0003060 ! results in morphogenesis of pronephric duct creation_date: 2010-07-02T10:18:09Z [Term] id: GO:0040007 name: growth namespace: biological_process def: "The increase in size or mass of an entire organism, a part of an organism or a cell." [GOC:bf, GOC:ma] comment: See also the biological process term 'cell growth ; GO:0016049'. subset: gocheck_do_not_annotate subset: goslim_chembl subset: goslim_pir subset: goslim_plant synonym: "growth pattern" RELATED [] synonym: "non-developmental growth" RELATED [GOC:mah] is_a: GO:0008150 ! biological_process disjoint_from: GO:0044848 ! biological phase relationship: RO:0002162 NCBITaxon:131567 ! in taxon cellular organisms [Term] id: GO:0040008 name: regulation of growth namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the growth of all or part of an organism so that it occurs at its proper speed, either globally or in a specific part of the organism's development." [GOC:ems, GOC:mah] is_a: GO:0050789 ! regulation of biological process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0040007 ! regulates growth relationship: RO:0002211 GO:0040007 ! regulates growth [Term] id: GO:0040011 name: locomotion namespace: biological_process def: "Self-propelled movement of a cell or organism from one location to another." [GOC:dgh] subset: goslim_chembl subset: goslim_pir is_a: GO:0008150 ! biological_process disjoint_from: GO:0044848 ! biological phase property_value: RO:0002161 NCBITaxon:451864 [Term] id: GO:0040012 name: regulation of locomotion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of locomotion of a cell or organism." [GOC:ems] is_a: GO:0050789 ! regulation of biological process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0040011 ! regulates locomotion relationship: RO:0002211 GO:0040011 ! regulates locomotion property_value: RO:0002161 NCBITaxon:451864 [Term] id: GO:0040013 name: negative regulation of locomotion namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of locomotion of a cell or organism." [GOC:go_curators] synonym: "down regulation of locomotion" EXACT [] synonym: "down-regulation of locomotion" EXACT [] synonym: "downregulation of locomotion" EXACT [] synonym: "inhibition of locomotion" NARROW [] is_a: GO:0040012 ! regulation of locomotion is_a: GO:0048519 ! negative regulation of biological process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0040011 ! negatively regulates locomotion relationship: RO:0002212 GO:0040011 ! negatively regulates locomotion property_value: RO:0002161 NCBITaxon:451864 [Term] id: GO:0040014 name: regulation of multicellular organism growth namespace: biological_process def: "Any process that modulates the frequency, rate or extent of growth of the body of an organism so that it reaches its usual body size." [GOC:dph, GOC:ems, GOC:tb] synonym: "regulation of body growth" EXACT [GOC:dph, GOC:tb] synonym: "regulation of body size" EXACT [GOC:dph, GOC:tb] is_a: GO:0048638 ! regulation of developmental growth is_a: GO:0051239 ! regulation of multicellular organismal process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0035264 ! regulates multicellular organism growth relationship: RO:0002211 GO:0035264 ! regulates multicellular organism growth property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0040015 name: negative regulation of multicellular organism growth namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of growth of an organism to reach its usual body size." [GOC:dph, GOC:ems, GOC:tb] synonym: "negative regulation of body growth" EXACT [GOC:dph, GOC:tb] synonym: "negative regulation of body size" EXACT [GOC:dph, GOC:tb] is_a: GO:0040014 ! regulation of multicellular organism growth is_a: GO:0048640 ! negative regulation of developmental growth is_a: GO:0051241 ! negative regulation of multicellular organismal process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0035264 ! negatively regulates multicellular organism growth relationship: RO:0002212 GO:0035264 ! negatively regulates multicellular organism growth property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0040016 name: embryonic cleavage namespace: biological_process def: "The first few specialized divisions of an activated animal egg." [GOC:clt, ISBN:0070524300] is_a: GO:0051301 ! cell division relationship: BFO:0000050 GO:0009790 ! part of embryo development property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0040017 name: positive regulation of locomotion namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of locomotion of a cell or organism." [GOC:go_curators] synonym: "activation of locomotion" NARROW [] synonym: "stimulation of locomotion" NARROW [] synonym: "up regulation of locomotion" EXACT [] synonym: "up-regulation of locomotion" EXACT [] synonym: "upregulation of locomotion" EXACT [] is_a: GO:0040012 ! regulation of locomotion is_a: GO:0048518 ! positive regulation of biological process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0040011 ! positively regulates locomotion relationship: RO:0002213 GO:0040011 ! positively regulates locomotion property_value: RO:0002161 NCBITaxon:451864 [Term] id: GO:0040018 name: positive regulation of multicellular organism growth namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of growth of an organism to reach its usual body size." [GOC:dph, GOC:go_curators, GOC:tb] synonym: "positive regulation of body growth" EXACT [GOC:dph, GOC:tb] synonym: "positive regulation of body size" EXACT [GOC:dph, GOC:tb] is_a: GO:0040014 ! regulation of multicellular organism growth is_a: GO:0048639 ! positive regulation of developmental growth is_a: GO:0051240 ! positive regulation of multicellular organismal process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0035264 ! positively regulates multicellular organism growth relationship: RO:0002213 GO:0035264 ! positively regulates multicellular organism growth property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0040019 name: positive regulation of embryonic development namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of embryonic development." [GOC:go_curators] synonym: "activation of embryonic development" NARROW [] synonym: "stimulation of embryonic development" NARROW [] synonym: "up regulation of embryonic development" EXACT [] synonym: "up-regulation of embryonic development" EXACT [] synonym: "upregulation of embryonic development" EXACT [] is_a: GO:0045995 ! regulation of embryonic development is_a: GO:0051094 ! positive regulation of developmental process is_a: GO:0051240 ! positive regulation of multicellular organismal process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0009790 ! positively regulates embryo development relationship: RO:0002213 GO:0009790 ! positively regulates embryo development property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0040020 name: regulation of meiotic nuclear division namespace: biological_process def: "Any process that modulates the frequency, rate or extent of meiotic nuclear division, the process in which the nucleus of a diploid cell divides twice forming four haploid cells, one or more of which usually function as gametes." [GOC:ems, GOC:ma] synonym: "regulation of meiosis" BROAD [GOC:vw] is_a: GO:0010564 ! regulation of cell cycle process is_a: GO:0051445 ! regulation of meiotic cell cycle is_a: GO:0051783 ! regulation of nuclear division intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0140013 ! regulates meiotic nuclear division relationship: RO:0002211 GO:0140013 ! regulates meiotic nuclear division [Term] id: GO:0040029 name: epigenetic regulation of gene expression namespace: biological_process def: "A process that modulates the frequency, rate or extent of gene expression through chromatin remodeling either by modifying higher order chromatin fiber structure, nucleosomal histones, or cytosine methylation of DNA. Once established, this regulation may be maintained over many cell divisions. It can also be heritable in the absence of the instigating signal." [PMID:10521337, PMID:11498582, PMID:22243696, PMID:34414474] subset: goslim_plant synonym: "regulation of gene expression, epigenetic" EXACT [] xref: Reactome:R-HSA-212165 "Epigenetic regulation of gene expression" xref: Reactome:R-HSA-8986944 "Transcriptional Regulation by MECP2" is_a: GO:0006338 ! chromatin remodeling is_a: GO:0010468 ! regulation of gene expression property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/22201" xsd:anyURI property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/24794" xsd:anyURI [Term] id: GO:0040034 name: regulation of development, heterochronic namespace: biological_process def: "Any process that modulates the consistent predetermined time point at which an integrated living unit or organism progresses from an initial condition to a later condition and the rate at which this time point is reached." [PMID:9442909] synonym: "developmental timing" RELATED [] synonym: "heterochronic regulation of development" EXACT [] synonym: "temporal regulation of development" EXACT [] is_a: GO:0050793 ! regulation of developmental process [Term] id: GO:0042044 name: fluid transport namespace: biological_process def: "The directed movement of substances that are in liquid form in normal living conditions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] subset: goslim_pir is_a: GO:0006810 ! transport [Term] id: GO:0042045 name: epithelial fluid transport namespace: biological_process def: "The directed movement of fluid across epithelia." [GOC:jl, PMID:11390830] is_a: GO:0042044 ! fluid transport is_a: GO:0070633 ! transepithelial transport intersection_of: GO:0042044 ! fluid transport intersection_of: RO:0002342 UBERON:0000483 ! results in transport across epithelium [Term] id: GO:0042048 name: olfactory behavior namespace: biological_process def: "The behavior of an organism in response to an odor." [GOC:jid, GOC:pr] synonym: "behavioral response to scent" EXACT [] synonym: "behavioral response to smell" EXACT [] synonym: "behavioural response to odour" EXACT [] synonym: "behavioural response to scent" EXACT [] synonym: "behavioural response to smell" EXACT [] synonym: "olfactory behaviour" EXACT [] is_a: GO:0007635 ! chemosensory behavior [Term] id: GO:0042051 name: compound eye photoreceptor development namespace: biological_process def: "The process whose specific outcome is the progression of a light-responsive receptor in the compound eye over time, from its formation to the mature structure." [GOC:bf] synonym: "adult eye photoreceptor development" NARROW [] is_a: GO:0042462 ! eye photoreceptor cell development relationship: BFO:0000050 GO:0001751 ! part of compound eye photoreceptor cell differentiation [Term] id: GO:0042053 name: regulation of dopamine metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving dopamine." [GOC:go_curators] synonym: "regulation of dopamine metabolism" EXACT [] is_a: GO:0042069 ! regulation of catecholamine metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0042417 ! regulates dopamine metabolic process relationship: RO:0002211 GO:0042417 ! regulates dopamine metabolic process property_value: RO:0002161 NCBITaxon:4751 [Term] id: GO:0042060 name: wound healing namespace: biological_process def: "The series of events that restore integrity to a damaged tissue, following an injury." [GOC:bf, PMID:15269788] subset: goslim_generic xref: Wikipedia:Wound_healing is_a: BFO:0000003 is_a: GO:0009611 ! response to wounding relationship: BFO:0000051 GO:0042246 ! has part tissue regeneration property_value: RO:0002161 NCBITaxon:4751 [Term] id: GO:0042063 name: gliogenesis namespace: biological_process def: "The process that results in the generation of glial cells. This includes the production of glial progenitors and their differentiation into mature glia." [GOC:dgh, GOC:jid] synonym: "glial cell generation" EXACT systematic_synonym [] is_a: GO:0022008 ! neurogenesis intersection_of: GO:0008150 ! biological_process intersection_of: RO:0002297 CL:0000125 ! results in formation of anatomical entity glial cell relationship: RO:0002297 CL:0000125 ! results in formation of anatomical entity glial cell [Term] id: GO:0042065 name: glial cell growth namespace: biological_process def: "Growth of glial cells, non-neuronal cells that provide support and nutrition, maintain homeostasis, form myelin, and participate in signal transmission in the nervous system." [GOC:dph, GOC:isa_complete, GOC:jid] is_a: GO:0048588 ! developmental cell growth intersection_of: GO:0040007 ! growth intersection_of: RO:0002343 CL:0000125 ! results in growth of glial cell relationship: BFO:0000050 GO:0042063 ! part of gliogenesis relationship: RO:0002343 CL:0000125 ! results in growth of glial cell [Term] id: GO:0042069 name: regulation of catecholamine metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving catecholamines." [GOC:go_curators] synonym: "regulation of catecholamine metabolism" EXACT [] is_a: GO:0033238 ! regulation of amine metabolic process is_a: GO:0080090 ! regulation of primary metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0006584 ! regulates catecholamine metabolic process relationship: RO:0002211 GO:0006584 ! regulates catecholamine metabolic process [Term] id: GO:0042073 name: intraciliary transport namespace: biological_process def: "The bidirectional movement of large protein complexes along microtubules within a cilium, mediated by motor proteins." [GOC:cilia, GOC:kmv, PMID:17981739, PMID:18180368, PMID:22869374] comment: Note that we deem cilium and microtubule-based flagellum to be equivalent. synonym: "IFT" RELATED [] synonym: "intraflagellar transport" EXACT [] synonym: "intraflagellar transport involved in cilium organization" EXACT [] synonym: "intraflagellar transport involved in microtubule-based flagellum organisation" EXACT [] xref: Wikipedia:Intraflagellar_transport is_a: GO:0010970 ! transport along microtubule intersection_of: GO:0006810 ! transport intersection_of: BFO:0000066 GO:0005929 ! occurs in cilium intersection_of: RO:0002341 GO:0005874 ! results in transport along microtubule intersection_of: RO:0004009 GO:0032991 ! has primary input protein-containing complex relationship: BFO:0000050 GO:0044782 ! part of cilium organization relationship: BFO:0000066 GO:0005929 ! occurs in cilium relationship: RO:0004009 GO:0032991 ! has primary input protein-containing complex property_value: RO:0002161 NCBITaxon:3176 property_value: RO:0002161 NCBITaxon:3378 property_value: RO:0002161 NCBITaxon:3398 property_value: RO:0002161 NCBITaxon:4890 property_value: RO:0002161 NCBITaxon:5782 [Term] id: GO:0042074 name: cell migration involved in gastrulation namespace: biological_process def: "The migration of individual cells within the blastocyst to help establish the multi-layered body plan of the organism (gastrulation). For example, the migration of cells from the surface to the interior of the embryo (ingression)." [GOC:jl, PMID:16099638] is_a: GO:0001667 ! ameboidal-type cell migration intersection_of: GO:0016477 ! cell migration intersection_of: BFO:0000050 GO:0007369 ! part of gastrulation relationship: BFO:0000050 GO:0007369 ! part of gastrulation [Term] id: GO:0042078 name: germ-line stem cell division namespace: biological_process def: "The self-renewing division of a germline stem cell to produce a daughter stem cell and a daughter germ cell, which will divide to form the gametes." [GOC:jid, PMID:2279698] synonym: "germ-line stem cell renewal" EXACT [] is_a: GO:0017145 ! stem cell division intersection_of: GO:0051301 ! cell division intersection_of: RO:0004009 CL:0000014 ! has primary input germ line stem cell relationship: BFO:0000050 GO:0007281 ! part of germ cell development relationship: RO:0004009 CL:0000014 ! has primary input germ line stem cell property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4751 [Term] id: GO:0042088 name: T-helper 1 type immune response namespace: biological_process def: "An immune response which is associated with resistance to intracellular bacteria, fungi, and protozoa, and pathological conditions such as arthritis, and which is typically orchestrated by the production of particular cytokines by T-helper 1 cells, most notably interferon-gamma, IL-2, and lymphotoxin." [GOC:add, ISBN:0781735149] synonym: "Th1 immune response" EXACT [] is_a: BFO:0000003 is_a: GO:0002460 ! adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains relationship: has_participant CL:0000545 ! T-helper 1 cell [Term] id: GO:0042092 name: type 2 immune response namespace: biological_process def: "An immune response which is associated with resistance to extracellular organisms such as helminths and pathological conditions such as allergy, which is orchestrated by the production of particular cytokines, most notably IL-4, IL-5, IL-10, and IL-13, by any of a variety of cell types including T-helper 2 cells, eosinophils, basophils, mast cells, and nuocytes, resulting in enhanced production of certain antibody isotypes and other effects." [GOC:add, ISBN:0781735149, PMID:18000958, PMID:18007680, PMID:20065995, PMID:20200518] synonym: "T-helper 2 type immune response" NARROW [GOC:add] synonym: "Th2 immune response" NARROW [GOC:add] is_a: GO:0006955 ! immune response property_value: RO:0002161 NCBITaxon:4895 [Term] id: GO:0042093 name: T-helper cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized thymocyte acquires specialized features of a T-helper cell." [GOC:ebc] synonym: "helper T cell differentiation" EXACT [CL:0000912] synonym: "T-helper cell development" RELATED [GOC:add] is_a: GO:0002294 ! CD4-positive, alpha-beta T cell differentiation involved in immune response intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000492 ! results in acquisition of features of CD4-positive helper T cell relationship: RO:0002162 NCBITaxon:7776 ! in taxon Gnathostomata relationship: RO:0002315 CL:0000492 ! results in acquisition of features of CD4-positive helper T cell [Term] id: GO:0042098 name: T cell proliferation namespace: biological_process def: "The expansion of a T cell population by cell division. Follows T cell activation." [GOC:jl] synonym: "T lymphocyte proliferation" EXACT [] synonym: "T-cell proliferation" EXACT [] synonym: "T-lymphocyte proliferation" EXACT [] is_a: GO:0042110 ! T cell activation is_a: GO:0046651 ! lymphocyte proliferation intersection_of: GO:0008283 ! cell population proliferation intersection_of: RO:0012003 CL:0000084 ! acts on population of T cell relationship: RO:0012003 CL:0000084 ! acts on population of T cell [Term] id: GO:0042100 name: B cell proliferation namespace: biological_process def: "The expansion of a B cell population by cell division. Follows B cell activation." [GOC:jl] synonym: "B lymphocyte proliferation" EXACT [] synonym: "B-cell proliferation" EXACT [] synonym: "B-lymphocyte proliferation" EXACT [] is_a: GO:0042113 ! B cell activation is_a: GO:0046651 ! lymphocyte proliferation intersection_of: GO:0008283 ! cell population proliferation intersection_of: RO:0012003 CL:0000236 ! acts on population of B cell relationship: RO:0012003 CL:0000236 ! acts on population of B cell [Term] id: GO:0042101 name: T cell receptor complex namespace: cellular_component def: "A protein complex that contains a disulfide-linked heterodimer of T cell receptor (TCR) chains, which are members of the immunoglobulin superfamily, and mediates antigen recognition, ultimately resulting in T cell activation. The TCR heterodimer is associated with the CD3 complex, which consists of the nonpolymorphic polypeptides gamma, delta, epsilon, zeta, and, in some cases, eta (an RNA splice variant of zeta) or Fc epsilon chains." [GOC:mah, ISBN:0781735149] synonym: "T lymphocyte receptor complex" EXACT [] synonym: "T-cell receptor complex" EXACT [] synonym: "T-lymphocyte receptor complex" EXACT [] synonym: "TCR" RELATED [] synonym: "TCR complex" EXACT [GOC:bf] xref: Wikipedia:T_cell_receptor is_a: GO:0098802 ! plasma membrane signaling receptor complex [Term] id: GO:0042102 name: positive regulation of T cell proliferation namespace: biological_process def: "Any process that activates or increases the rate or extent of T cell proliferation." [GOC:ai] synonym: "activation of T cell proliferation" NARROW [] synonym: "positive regulation of T lymphocyte proliferation" EXACT [] synonym: "positive regulation of T-lymphocyte proliferation" EXACT [] synonym: "stimulation of T cell proliferation" NARROW [] synonym: "up regulation of T cell proliferation" EXACT [] synonym: "up-regulation of T cell proliferation" EXACT [] synonym: "upregulation of T cell proliferation" EXACT [] is_a: GO:0042129 ! regulation of T cell proliferation is_a: GO:0050671 ! positive regulation of lymphocyte proliferation is_a: GO:0050870 ! positive regulation of T cell activation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0042098 ! positively regulates T cell proliferation relationship: RO:0002213 GO:0042098 ! positively regulates T cell proliferation [Term] id: GO:0042103 name: positive regulation of T cell homeostatic proliferation namespace: biological_process def: "Any process that activates or increases the rate or extent of resting T cell proliferation." [GOC:jl] synonym: "activation of T cell homeostatic proliferation" NARROW [] synonym: "positive regulation of resting T cell proliferation" EXACT [] synonym: "positive regulation of T lymphocyte homeostatic proliferation" EXACT [] synonym: "positive regulation of T-cell homeostatic proliferation" EXACT [] synonym: "positive regulation of T-lymphocyte homeostatic proliferation" EXACT [] synonym: "stimulation of T cell homeostatic proliferation" NARROW [] synonym: "up regulation of T cell homeostatic proliferation" EXACT [] synonym: "up-regulation of T cell homeostatic proliferation" EXACT [] synonym: "upregulation of T cell homeostatic proliferation" EXACT [] is_a: GO:0042102 ! positive regulation of T cell proliferation is_a: GO:0046013 ! regulation of T cell homeostatic proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0001777 ! positively regulates T cell homeostatic proliferation relationship: RO:0002213 GO:0001777 ! positively regulates T cell homeostatic proliferation [Term] id: GO:0042105 name: alpha-beta T cell receptor complex namespace: cellular_component def: "A T cell receptor complex in which the TCR heterodimer comprises alpha and beta chains, associated with the CD3 complex; recognizes a complex consisting of an antigen-derived peptide bound to a class I or class II MHC protein." [GOC:mah, ISBN:0781735149] synonym: "alpha-beta T lymphocyte receptor complex" EXACT [] synonym: "alpha-beta T-cell receptor complex" EXACT [] synonym: "alpha-beta T-lymphocyte receptor complex" EXACT [] synonym: "alpha-beta TCR complex" EXACT [] is_a: GO:0042101 ! T cell receptor complex [Term] id: GO:0042106 name: gamma-delta T cell receptor complex namespace: cellular_component def: "A T cell receptor complex in which the TCR heterodimer comprises gamma and delta chains, associated with the CD3 complex; recognizes antigen directly, without a requirement for processing and presentation by an MHC protein." [GOC:mah, ISBN:0781735149] synonym: "gamma-delta T lymphocyte receptor complex" EXACT [] synonym: "gamma-delta T-cell receptor complex" EXACT [] synonym: "gamma-delta T-lymphocyte receptor complex" EXACT [] synonym: "gamma-delta TCR complex" EXACT [] is_a: GO:0042101 ! T cell receptor complex [Term] id: GO:0042110 name: T cell activation namespace: biological_process def: "The change in morphology and behavior of a mature or immature T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific." [GOC:mgi_curators, ISBN:0781735149] synonym: "T lymphocyte activation" EXACT [] synonym: "T-cell activation" EXACT [] synonym: "T-lymphocyte activation" EXACT [] is_a: GO:0046649 ! lymphocyte activation intersection_of: GO:0001775 ! cell activation intersection_of: RO:0004009 CL:0000084 ! has primary input T cell relationship: RO:0004009 CL:0000084 ! has primary input T cell [Term] id: GO:0042113 name: B cell activation namespace: biological_process def: "The change in morphology and behavior of a mature or immature B cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific." [GOC:mgi_curators, ISBN:0781735149] synonym: "B lymphocyte activation" EXACT [] synonym: "B-cell activation" EXACT [] synonym: "B-lymphocyte activation" EXACT [] is_a: GO:0046649 ! lymphocyte activation intersection_of: GO:0001775 ! cell activation intersection_of: RO:0004009 CL:0000236 ! has primary input B cell relationship: RO:0004009 CL:0000236 ! has primary input B cell [Term] id: GO:0042116 name: macrophage activation namespace: biological_process def: "A change in morphology and behavior of a macrophage resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor." [GOC:mgi_curators, ISBN:0781735149, PMID:14506301] synonym: "macrophage polarization" EXACT [] is_a: GO:0002274 ! myeloid leukocyte activation intersection_of: GO:0001775 ! cell activation intersection_of: RO:0004009 CL:0000235 ! has primary input macrophage relationship: RO:0004009 CL:0000235 ! has primary input macrophage [Term] id: GO:0042117 name: monocyte activation namespace: biological_process def: "The change in morphology and behavior of a monocyte resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor." [GOC:mgi_curators, ISBN:0781735149] is_a: GO:0002274 ! myeloid leukocyte activation intersection_of: GO:0001775 ! cell activation intersection_of: RO:0004009 CL:0000576 ! has primary input monocyte relationship: RO:0004009 CL:0000576 ! has primary input monocyte [Term] id: GO:0042118 name: endothelial cell activation namespace: biological_process def: "The change in morphology and behavior of an endothelial cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor." [GOC:mgi_curators, ISBN:0781735149, PMID:12851652, PMID:14581484] is_a: BFO:0000003 is_a: GO:0001775 ! cell activation intersection_of: GO:0001775 ! cell activation intersection_of: RO:0004009 CL:0000115 ! has primary input endothelial cell relationship: RO:0004009 CL:0000115 ! has primary input endothelial cell [Term] id: GO:0042119 name: neutrophil activation namespace: biological_process def: "The change in morphology and behavior of a neutrophil resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor." [GOC:mgi_curators, ISBN:0781735149] is_a: GO:0036230 ! granulocyte activation intersection_of: GO:0001775 ! cell activation intersection_of: RO:0004009 CL:0000775 ! has primary input neutrophil relationship: RO:0004009 CL:0000775 ! has primary input neutrophil [Term] id: GO:0042127 name: regulation of cell population proliferation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cell proliferation." [GOC:jl] synonym: "regulation of cell proliferation" RELATED [] is_a: GO:0050794 ! regulation of cellular process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0008283 ! regulates cell population proliferation relationship: RO:0002211 GO:0008283 ! regulates cell population proliferation property_value: RO:0002161 NCBITaxon:4751 [Term] id: GO:0042129 name: regulation of T cell proliferation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of T cell proliferation." [GOC:jl] synonym: "regulation of T lymphocyte proliferation" EXACT [] synonym: "regulation of T-cell proliferation" EXACT [] synonym: "regulation of T-lymphocyte proliferation" EXACT [] is_a: GO:0050670 ! regulation of lymphocyte proliferation is_a: GO:0050863 ! regulation of T cell activation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0042098 ! regulates T cell proliferation relationship: RO:0002211 GO:0042098 ! regulates T cell proliferation [Term] id: GO:0042130 name: negative regulation of T cell proliferation namespace: biological_process def: "Any process that stops, prevents or reduces the rate or extent of T cell proliferation." [GOC:jl] synonym: "down regulation of T cell proliferation" EXACT [] synonym: "down-regulation of T cell proliferation" EXACT [] synonym: "downregulation of T cell proliferation" EXACT [] synonym: "inhibition of T cell proliferation" NARROW [] synonym: "negative regulation of T lymphocyte proliferation" EXACT [] synonym: "negative regulation of T-cell proliferation" EXACT [] synonym: "negative regulation of T-lymphocyte proliferation" EXACT [] is_a: GO:0042129 ! regulation of T cell proliferation is_a: GO:0050672 ! negative regulation of lymphocyte proliferation is_a: GO:0050868 ! negative regulation of T cell activation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0042098 ! negatively regulates T cell proliferation relationship: RO:0002212 GO:0042098 ! negatively regulates T cell proliferation [Term] id: GO:0042151 name: nematocyst namespace: cellular_component def: "An organelle found in cnidoblast (nematoblast) cells. When matured, these stinging organelles store toxins and can deliver them when the cnidocil (a short extension of the cnidocyst) is stimulated by a prey or another stimulus." [DOI:10.1139/z02-135, GOC:jl] synonym: "cnidocyst" EXACT [] xref: Wikipedia:Cnidocyte is_a: GO:0043232 ! intracellular membraneless organelle relationship: BFO:0000050 GO:0005938 ! part of cell cortex relationship: RO:0002162 NCBITaxon:33208 ! in taxon Metazoa [Term] id: GO:0042157 name: lipoprotein metabolic process namespace: biological_process def: "The chemical reactions and pathways involving any conjugated, water-soluble protein in which the covalently attached nonprotein group consists of a lipid or lipids." [ISBN:0198506732] synonym: "lipoprotein metabolism" EXACT [] is_a: GO:0019538 ! protein metabolic process intersection_of: GO:0008152 ! metabolic process intersection_of: RO:0004007 CHEBI:6495 ! has primary input or output relationship: RO:0004007 CHEBI:6495 ! has primary input or output [Term] id: GO:0042158 name: lipoprotein biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of any conjugated, water-soluble protein in which the covalently attached nonprotein group consists of a lipid or lipids." [ISBN:0198506732] synonym: "lipoprotein anabolism" EXACT [] synonym: "lipoprotein biosynthesis" EXACT [] synonym: "lipoprotein formation" EXACT [] synonym: "lipoprotein synthesis" EXACT [] is_a: GO:0009059 ! macromolecule biosynthetic process is_a: GO:0042157 ! lipoprotein metabolic process intersection_of: GO:0009058 ! biosynthetic process intersection_of: RO:0004008 CHEBI:6495 ! has primary output relationship: RO:0004008 CHEBI:6495 ! has primary output [Term] id: GO:0042159 name: lipoprotein catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of any conjugated, water-soluble protein in which the covalently attached nonprotein group consists of a lipid or lipids." [ISBN:0198506732] synonym: "lipoprotein breakdown" EXACT [] synonym: "lipoprotein catabolism" EXACT [] synonym: "lipoprotein degradation" EXACT [] is_a: GO:0030163 ! protein catabolic process is_a: GO:0042157 ! lipoprotein metabolic process intersection_of: GO:0009056 ! catabolic process intersection_of: RO:0004009 CHEBI:6495 ! has primary input relationship: RO:0004009 CHEBI:6495 ! has primary input [Term] id: GO:0042166 name: acetylcholine binding namespace: molecular_function def: "Binding to acetylcholine, an acetic acid ester of the organic base choline that functions as a neurotransmitter, released at the synapses of parasympathetic nerves and at neuromuscular junctions." [GOC:ai] is_a: GO:0043169 ! cation binding intersection_of: GO:0005488 ! binding intersection_of: RO:0004009 CHEBI:15355 ! has primary input relationship: RO:0004009 CHEBI:15355 ! has primary input [Term] id: GO:0042170 name: plastid membrane namespace: cellular_component def: "Either of the lipid bilayers that surround a plastid and form the plastid envelope." [GOC:mah] is_a: GO:0031090 ! organelle membrane intersection_of: GO:0016020 ! membrane intersection_of: BFO:0000050 GO:0009536 ! part of plastid relationship: BFO:0000050 GO:0009526 ! part of plastid envelope property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:28009 property_value: RO:0002161 NCBITaxon:33208 property_value: RO:0002161 NCBITaxon:4751 property_value: RO:0002161 NCBITaxon:554915 [Term] id: GO:0042173 name: regulation of sporulation resulting in formation of a cellular spore namespace: biological_process def: "Any process that modulates the frequency, rate or extent of spore formation." [GOC:jl] is_a: GO:0043937 ! regulation of sporulation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0030435 ! regulates sporulation resulting in formation of a cellular spore relationship: RO:0002211 GO:0030435 ! regulates sporulation resulting in formation of a cellular spore [Term] id: GO:0042174 name: negative regulation of sporulation resulting in formation of a cellular spore namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of sporulation." [GOC:go_curators] synonym: "down regulation of sporulation" EXACT [] synonym: "down-regulation of sporulation" EXACT [] synonym: "downregulation of sporulation" EXACT [] synonym: "inhibition of sporulation" NARROW [] is_a: GO:0042173 ! regulation of sporulation resulting in formation of a cellular spore is_a: GO:0043939 ! negative regulation of sporulation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0030435 ! negatively regulates sporulation resulting in formation of a cellular spore relationship: RO:0002212 GO:0030435 ! negatively regulates sporulation resulting in formation of a cellular spore [Term] id: GO:0042175 name: nuclear outer membrane-endoplasmic reticulum membrane network namespace: cellular_component def: "The continuous network of membranes encompassing the nuclear outer membrane and the endoplasmic reticulum membrane." [GOC:bf, GOC:jl, GOC:mah, GOC:mcc, GOC:pr, GOC:vw] synonym: "NE-ER continuum" RELATED [] synonym: "NE-ER network" RELATED [] synonym: "nuclear envelope-endoplasmic reticulum continuum" RELATED [] synonym: "nuclear envelope-endoplasmic reticulum network" RELATED [GOC:mah] synonym: "nuclear envelope-ER network" RELATED [] synonym: "nuclear membrane-endoplasmic reticulum continuum" EXACT [GOC:mah] synonym: "nuclear membrane-ER network" EXACT [GOC:mah] is_a: GO:0016020 ! membrane relationship: BFO:0000050 GO:0012505 ! part of endomembrane system [Term] id: GO:0042176 name: regulation of protein catabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds." [GOC:go_curators, GOC:jl] synonym: "regulation of cellular protein breakdown" EXACT [GOC:TermGenie] synonym: "regulation of cellular protein catabolic process" EXACT [] synonym: "regulation of cellular protein catabolism" EXACT [GOC:TermGenie] synonym: "regulation of cellular protein degradation" EXACT [GOC:TermGenie] synonym: "regulation of cyclin breakdown" NARROW [GOC:obol] synonym: "regulation of cyclin catabolic process" NARROW [] synonym: "regulation of cyclin catabolism" NARROW [GOC:obol] synonym: "regulation of cyclin degradation" NARROW [GOC:obol] synonym: "regulation of degradation of cyclin" NARROW [GOC:obol] synonym: "regulation of protein breakdown" EXACT [] synonym: "regulation of protein catabolism" EXACT [] synonym: "regulation of protein degradation" EXACT [] is_a: GO:0009894 ! regulation of catabolic process is_a: GO:0051246 ! regulation of protein metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0030163 ! regulates protein catabolic process relationship: RO:0002211 GO:0030163 ! regulates protein catabolic process property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/23112" xsd:anyURI creation_date: 2014-08-21T15:05:45Z [Term] id: GO:0042177 name: negative regulation of protein catabolic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein catabolic process." [GO_REF:0000058, GOC:kmv, GOC:obol, GOC:TermGenie, PMID:24785082] synonym: "down regulation of cellular protein breakdown" EXACT [GOC:TermGenie] synonym: "down regulation of cellular protein catabolic process" EXACT [GOC:TermGenie] synonym: "down regulation of cellular protein catabolism" EXACT [GOC:TermGenie] synonym: "down regulation of cellular protein degradation" EXACT [GOC:TermGenie] synonym: "down regulation of protein catabolic process" EXACT [] synonym: "down-regulation of cellular protein breakdown" EXACT [GOC:TermGenie] synonym: "down-regulation of cellular protein catabolic process" EXACT [GOC:TermGenie] synonym: "down-regulation of cellular protein catabolism" EXACT [GOC:TermGenie] synonym: "down-regulation of cellular protein degradation" EXACT [GOC:TermGenie] synonym: "down-regulation of protein catabolic process" EXACT [] synonym: "downregulation of cellular protein breakdown" EXACT [GOC:TermGenie] synonym: "downregulation of cellular protein catabolic process" EXACT [GOC:TermGenie] synonym: "downregulation of cellular protein catabolism" EXACT [GOC:TermGenie] synonym: "downregulation of cellular protein degradation" EXACT [GOC:TermGenie] synonym: "downregulation of protein catabolic process" EXACT [] synonym: "inhibition of cellular protein breakdown" NARROW [GOC:TermGenie] synonym: "inhibition of cellular protein catabolic process" NARROW [GOC:TermGenie] synonym: "inhibition of cellular protein catabolism" NARROW [GOC:TermGenie] synonym: "inhibition of cellular protein degradation" NARROW [GOC:TermGenie] synonym: "inhibition of protein catabolic process" NARROW [] synonym: "negative regulation of cellular protein breakdown" EXACT [GOC:TermGenie] synonym: "negative regulation of cellular protein catabolic process" EXACT [] synonym: "negative regulation of cellular protein catabolism" EXACT [GOC:TermGenie] synonym: "negative regulation of cellular protein degradation" EXACT [GOC:TermGenie] synonym: "negative regulation of protein breakdown" EXACT [] synonym: "negative regulation of protein catabolism" EXACT [] synonym: "negative regulation of protein degradation" EXACT [] is_a: GO:0009895 ! negative regulation of catabolic process is_a: GO:0042176 ! regulation of protein catabolic process is_a: GO:0051248 ! negative regulation of protein metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0030163 ! negatively regulates protein catabolic process relationship: RO:0002212 GO:0030163 ! negatively regulates protein catabolic process property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/23112" xsd:anyURI [Term] id: GO:0042180 name: ketone metabolic process namespace: biological_process def: "The chemical reactions and pathways involving any of a class of organic compounds that contain the carbonyl group, CO, and in which the carbonyl group is bonded only to carbon atoms, as carried out by individual cells. The general formula for a ketone is RCOR, where R and R are alkyl or aryl groups." [GOC:jl, ISBN:0787650153] subset: goslim_pir synonym: "ketone metabolism" EXACT [] is_a: BFO:0000003 is_a: GO:0008152 ! metabolic process intersection_of: GO:0008152 ! metabolic process intersection_of: RO:0004007 CHEBI:17087 ! has primary input or output relationship: RO:0004007 CHEBI:17087 ! has primary input or output property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/28908" xsd:anyURI [Term] id: GO:0042181 name: ketone biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of ketones, a class of organic compounds that contain the carbonyl group, CO, and in which the carbonyl group is bonded only to carbon atoms. The general formula for a ketone is RCOR, where R and R are alkyl or aryl groups." [GOC:go_curators] synonym: "ketone anabolism" EXACT [] synonym: "ketone biosynthesis" EXACT [] synonym: "ketone formation" EXACT [] synonym: "ketone synthesis" EXACT [] is_a: GO:0042180 ! ketone metabolic process is_a: GO:0044283 ! small molecule biosynthetic process intersection_of: GO:0009058 ! biosynthetic process intersection_of: RO:0004008 CHEBI:17087 ! has primary output relationship: RO:0004008 CHEBI:17087 ! has primary output [Term] id: GO:0042182 name: ketone catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of ketones, a class of organic compounds that contain the carbonyl group, CO, and in which the carbonyl group is bonded only to carbon atoms. The general formula for a ketone is RCOR, where R and R are alkyl or aryl groups." [GOC:go_curators] synonym: "ketone breakdown" EXACT [] synonym: "ketone catabolism" EXACT [] synonym: "ketone degradation" EXACT [] is_a: GO:0042180 ! ketone metabolic process is_a: GO:0044282 ! small molecule catabolic process intersection_of: GO:0009056 ! catabolic process intersection_of: RO:0004009 CHEBI:17087 ! has primary input relationship: RO:0004009 CHEBI:17087 ! has primary input [Term] id: GO:0042219 name: modified amino acid catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of compounds derived from amino acids, organic acids containing one or more amino substituents." [GOC:ai] synonym: "amino acid derivative catabolic process" EXACT [] synonym: "cellular amino acid derivative breakdown" EXACT [] synonym: "cellular amino acid derivative catabolic process" EXACT [] synonym: "cellular amino acid derivative catabolism" EXACT [] synonym: "cellular amino acid derivative degradation" EXACT [] synonym: "cellular modified amino acid breakdown" EXACT [GOC:mah] synonym: "cellular modified amino acid catabolic process" EXACT [GOC:mah] synonym: "cellular modified amino acid catabolism" EXACT [GOC:mah] synonym: "cellular modified amino acid degradation" EXACT [GOC:mah] synonym: "modified amino acid catabolism" EXACT [GOC:mah] is_a: GO:0006575 ! modified amino acid metabolic process is_a: GO:0009056 ! catabolic process intersection_of: GO:0009056 ! catabolic process intersection_of: RO:0004009 CHEBI:83821 ! has primary input relationship: RO:0004009 CHEBI:83821 ! has primary input property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/28908" xsd:anyURI [Term] id: GO:0042221 name: response to chemical namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chemical stimulus." [GOC:jl] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_annotate subset: goslim_candida subset: goslim_drosophila subset: goslim_metagenomics subset: goslim_plant subset: goslim_plant_ribbon subset: goslim_yeast synonym: "response to chemical stimulus" EXACT [GOC:dos] synonym: "response to chemical substance" EXACT [] is_a: BFO:0000003 is_a: GO:0050896 ! response to stimulus intersection_of: GO:0050896 ! response to stimulus intersection_of: RO:0004009 CHEBI:24431 ! has primary input relationship: RO:0004009 CHEBI:24431 ! has primary input [Term] id: GO:0042246 name: tissue regeneration namespace: biological_process def: "The regrowth of lost or destroyed tissues." [GOC:curators] is_a: GO:0031099 ! regeneration is_a: GO:0048589 ! developmental growth intersection_of: GO:0031099 ! regeneration intersection_of: RO:0002299 UBERON:0000479 ! results in maturation of tissue relationship: RO:0002299 UBERON:0000479 ! results in maturation of tissue property_value: RO:0002161 NCBITaxon:4751 [Term] id: GO:0042254 name: ribosome biogenesis namespace: biological_process def: "A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of ribosome subunits; includes transport to the sites of protein synthesis." [GOC:ma, PMID:26404467, Wikipedia:Ribosome_biogenesis] subset: goslim_candida subset: goslim_chembl subset: goslim_drosophila subset: goslim_generic subset: goslim_pir subset: goslim_pombe subset: goslim_prokaryote subset: goslim_prokaryote_ribbon synonym: "ribosome biogenesis and assembly" EXACT [] is_a: GO:0022613 ! ribonucleoprotein complex biogenesis [Term] id: GO:0042255 name: ribosome assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of the mature ribosome and of its subunits." [GOC:ma, PMID:30467428] subset: goslim_yeast synonym: "ribosomal subunit assembly" NARROW [GOC:mah, GOC:vw] is_a: GO:0140694 ! membraneless organelle assembly intersection_of: GO:0022607 ! cellular component assembly intersection_of: RO:0002588 GO:0005840 ! results in assembly of ribosome relationship: BFO:0000050 GO:0042254 ! part of ribosome biogenesis relationship: RO:0002588 GO:0005840 ! results in assembly of ribosome [Term] id: GO:0042267 name: natural killer cell mediated cytotoxicity namespace: biological_process def: "The directed killing of a target cell by a natural killer cell through the release of granules containing cytotoxic mediators or through the engagement of death receptors." [GOC:add, GOC:pr] comment: Note that either or both mechanisms mentioned in the definition may be used in this process. Note that both granule release and the engagement of death receptors on target cells result in induction of apoptosis in the target cell. synonym: "killer activity" RELATED [] synonym: "natural killer cell mediated cell death" EXACT [] synonym: "natural killer cell mediated cell killing" EXACT [] synonym: "natural killer cell mediated cytolysis" RELATED [] synonym: "natural killer-cell mediated cytolysis" RELATED [] synonym: "NK cell mediated cell death" EXACT [] synonym: "NK cell mediated cell killing" EXACT [] synonym: "NK cell mediated cytolysis" RELATED [] synonym: "NK cell mediated cytotoxicity" EXACT [] is_a: GO:0001909 ! leukocyte mediated cytotoxicity is_a: GO:0002228 ! natural killer cell mediated immunity intersection_of: GO:0001906 ! cell killing intersection_of: RO:0002608 CL:0000623 ! process has causal agent natural killer cell [Term] id: GO:0042269 name: regulation of natural killer cell mediated cytotoxicity namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of natural killer cell mediated cytotoxicity." [GOC:add, ISBN:0781735149] synonym: "regulation of natural killer cell mediated cell death" EXACT [] synonym: "regulation of natural killer cell mediated cell killing" EXACT [] synonym: "regulation of natural killer cell mediated cytolysis" RELATED [] synonym: "regulation of natural killer-cell mediated cytolysis" RELATED [] synonym: "regulation of NK cell mediated cell death" EXACT [] synonym: "regulation of NK cell mediated cell killing" EXACT [] synonym: "regulation of NK cell mediated cytolysis" RELATED [] synonym: "regulation of NK cell mediated cytotoxicity" RELATED [] is_a: GO:0001910 ! regulation of leukocyte mediated cytotoxicity is_a: GO:0002715 ! regulation of natural killer cell mediated immunity intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0042267 ! regulates natural killer cell mediated cytotoxicity relationship: RO:0002211 GO:0042267 ! regulates natural killer cell mediated cytotoxicity [Term] id: GO:0042277 name: peptide binding namespace: molecular_function def: "Binding to a peptide, an organic compound comprising two or more amino acids linked by peptide bonds." [GOC:jl] subset: goslim_chembl subset: goslim_pir is_a: BFO:0000003 is_a: GO:0005488 ! binding intersection_of: GO:0005488 ! binding intersection_of: RO:0004009 CHEBI:60466 ! has primary input relationship: RO:0004009 CHEBI:60466 ! has primary input [Term] id: GO:0042287 name: MHC protein binding namespace: molecular_function def: "Binding to a major histocompatibility complex molecule; a set of molecules displayed on cell surfaces that are responsible for lymphocyte recognition and antigen presentation." [GOC:jl] comment: Note that this term does not include binding to the antigen peptide bound to the MHC protein, for this also annotate to 'peptide antigen binding ; GO:0042605' or one of its children. synonym: "major histocompatibility complex binding" EXACT [] synonym: "major histocompatibility complex ligand" NARROW [] is_a: GO:0005102 ! signaling receptor binding [Term] id: GO:0042301 name: phosphate ion binding namespace: molecular_function def: "Binding to a phosphate ion." [GOC:jl] is_a: GO:0043168 ! anion binding intersection_of: GO:0005488 ! binding intersection_of: RO:0004009 CHEBI:43474 ! has primary input relationship: RO:0004009 CHEBI:43474 ! has primary input [Term] id: GO:0042303 name: molting cycle namespace: biological_process def: "The periodic casting off and regeneration of an outer covering of cuticle, feathers, hair, horns, skin, etc." [GOC:jl, ISBN:0198506732] subset: goslim_drosophila subset: goslim_pir is_a: GO:0032501 ! multicellular organismal process property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0042304 name: regulation of fatty acid biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of fatty acids, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils." [GOC:go_curators, GOC:jl] synonym: "regulation of fatty acid anabolism" EXACT [] synonym: "regulation of fatty acid biosynthesis" EXACT [] synonym: "regulation of fatty acid formation" EXACT [] synonym: "regulation of fatty acid synthesis" EXACT [] xref: Reactome:R-HSA-163680 "AMPK inhibits chREBP transcriptional activation activity" is_a: GO:0019217 ! regulation of fatty acid metabolic process is_a: GO:0046890 ! regulation of lipid biosynthetic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0006633 ! regulates fatty acid biosynthetic process relationship: RO:0002211 GO:0006633 ! regulates fatty acid biosynthetic process [Term] id: GO:0042306 name: regulation of protein import into nucleus namespace: biological_process def: "Any process that modulates the frequency, rate or extent of movement of proteins from the cytoplasm to the nucleus." [GOC:jl] synonym: "regulation of protein import into cell nucleus" EXACT [] synonym: "regulation of protein transport from cytoplasm to nucleus" EXACT [] synonym: "regulation of protein-nucleus import" EXACT [] is_a: GO:0033157 ! regulation of intracellular protein transport is_a: GO:0046822 ! regulation of nucleocytoplasmic transport is_a: GO:1900180 ! regulation of protein localization to nucleus intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0006606 ! regulates protein import into nucleus relationship: RO:0002211 GO:0006606 ! regulates protein import into nucleus [Term] id: GO:0042307 name: positive regulation of protein import into nucleus namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of movement of proteins from the cytoplasm into the nucleus." [GOC:jl] synonym: "activation of protein import into nucleus" NARROW [] synonym: "positive regulation of protein import into cell nucleus" EXACT [] synonym: "positive regulation of protein transport from cytoplasm to nucleus" EXACT [] synonym: "positive regulation of protein-nucleus import" EXACT [] synonym: "stimulation of protein import into nucleus" NARROW [] synonym: "up regulation of protein import into nucleus" EXACT [] synonym: "up-regulation of protein import into nucleus" EXACT [] synonym: "upregulation of protein import into nucleus" EXACT [] is_a: GO:0042306 ! regulation of protein import into nucleus is_a: GO:0046824 ! positive regulation of nucleocytoplasmic transport is_a: GO:0090316 ! positive regulation of intracellular protein transport is_a: GO:1900182 ! positive regulation of protein localization to nucleus intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0006606 ! positively regulates protein import into nucleus relationship: RO:0002213 GO:0006606 ! positively regulates protein import into nucleus [Term] id: GO:0042308 name: negative regulation of protein import into nucleus namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the movement of proteins from the cytoplasm into the nucleus." [GOC:jl] synonym: "down regulation of protein import into nucleus" EXACT [] synonym: "down-regulation of protein import into nucleus" EXACT [] synonym: "downregulation of protein import into nucleus" EXACT [] synonym: "inhibition of protein import into nucleus" NARROW [] synonym: "negative regulation of protein import into cell nucleus" EXACT [] synonym: "negative regulation of protein transport from cytoplasm to nucleus" EXACT [] synonym: "negative regulation of protein-nucleus import" EXACT [] is_a: GO:0042306 ! regulation of protein import into nucleus is_a: GO:0046823 ! negative regulation of nucleocytoplasmic transport is_a: GO:0090317 ! negative regulation of intracellular protein transport is_a: GO:1900181 ! negative regulation of protein localization to nucleus intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0006606 ! negatively regulates protein import into nucleus relationship: RO:0002212 GO:0006606 ! negatively regulates protein import into nucleus [Term] id: GO:0042325 name: regulation of phosphorylation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of addition of phosphate groups into a molecule." [GOC:jl] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_obsoletion_candidate is_a: GO:0051174 ! regulation of phosphorus metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0016310 ! regulates phosphorylation relationship: RO:0002211 GO:0016310 ! regulates phosphorylation property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/27189" xsd:anyURI [Term] id: GO:0042326 name: negative regulation of phosphorylation namespace: biological_process def: "Any process that stops, prevents or decreases the rate of addition of phosphate groups to a molecule." [GOC:jl] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_obsoletion_candidate synonym: "down regulation of phosphorylation" EXACT [] synonym: "down-regulation of phosphorylation" EXACT [] synonym: "downregulation of phosphorylation" EXACT [] synonym: "inhibition of phosphorylation" NARROW [] is_a: GO:0042325 ! regulation of phosphorylation is_a: GO:0045936 ! negative regulation of phosphate metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0016310 ! negatively regulates phosphorylation relationship: RO:0002212 GO:0016310 ! negatively regulates phosphorylation property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/27189" xsd:anyURI [Term] id: GO:0042327 name: positive regulation of phosphorylation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to a molecule." [GOC:jl] synonym: "activation of phosphorylation" NARROW [] synonym: "stimulation of phosphorylation" NARROW [] synonym: "up regulation of phosphorylation" EXACT [] synonym: "up-regulation of phosphorylation" EXACT [] synonym: "upregulation of phosphorylation" EXACT [] is_a: GO:0042325 ! regulation of phosphorylation is_a: GO:0045937 ! positive regulation of phosphate metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0016310 ! positively regulates phosphorylation relationship: RO:0002213 GO:0016310 ! positively regulates phosphorylation [Term] id: GO:0042330 name: taxis namespace: biological_process def: "The directed movement of a motile cell or organism in response to an external stimulus." [GOC:jl, ISBN:0192801023] synonym: "directed movement in response to stimulus" EXACT [] xref: Wikipedia:Taxis is_a: GO:0040011 ! locomotion relationship: BFO:0000050 GO:0009605 ! part of response to external stimulus property_value: RO:0002161 NCBITaxon:451864 [Term] id: GO:0042379 name: chemokine receptor binding namespace: molecular_function def: "Binding to a chemokine receptor." [GOC:ai] synonym: "chemokine receptor ligand" NARROW [] is_a: GO:0001664 ! G protein-coupled receptor binding is_a: GO:0005126 ! cytokine receptor binding intersection_of: GO:0005488 ! binding intersection_of: RO:0004009 PR:000001128 ! has primary input chemokine receptor relationship: RO:0004009 PR:000001128 ! has primary input chemokine receptor [Term] id: GO:0042386 name: hemocyte differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires the characteristics of a mature hemocyte. Hemocytes are blood cells associated with a hemocoel (the cavity containing most of the major organs of the arthropod body) which are involved in defense and clotting of hemolymph, but not involved in transport of oxygen." [CL:0000387, GOC:jl, GOC:mtg_sensu, PMID:9550723] synonym: "arthropod blood cell differentiation" EXACT [] is_a: GO:0002376 ! immune system process is_a: GO:0030154 ! cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000387 ! results in acquisition of features of hemocyte (sensu Arthropoda) relationship: RO:0002315 CL:0000387 ! results in acquisition of features of hemocyte (sensu Arthropoda) [Term] id: GO:0042387 name: plasmatocyte differentiation namespace: biological_process def: "The process in which a hemocyte precursor cell acquires the characteristics of the phagocytic blood-cell type, the plasmatocyte. Plasmatocytes are a class of arthropod hemocytes important in the cellular defense response." [PMID:11921077, PMID:8174791] is_a: GO:0042386 ! hemocyte differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000394 ! results in acquisition of features of plasmatocyte relationship: RO:0002315 CL:0000394 ! results in acquisition of features of plasmatocyte [Term] id: GO:0042391 name: regulation of membrane potential namespace: biological_process def: "Any process that modulates the establishment or extent of a membrane potential, the electric potential existing across any membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane." [GOC:jl, GOC:mtg_cardio, GOC:tb, ISBN:0198506732] is_a: BFO:0000003 is_a: GO:0065008 ! regulation of biological quality relationship: BFO:0000051 GO:0034220 ! has part monoatomic ion transmembrane transport [Term] id: GO:0042398 name: modified amino acid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of compounds derived from amino acids, organic acids containing one or more amino substituents." [GOC:ai] synonym: "amino acid derivative biosynthetic process" EXACT [] synonym: "cellular amino acid derivative anabolism" EXACT [] synonym: "cellular amino acid derivative biosynthesis" EXACT [] synonym: "cellular amino acid derivative biosynthetic process" EXACT [] synonym: "cellular amino acid derivative formation" EXACT [] synonym: "cellular amino acid derivative synthesis" EXACT [] synonym: "cellular modified amino acid anabolism" EXACT [GOC:mah] synonym: "cellular modified amino acid biosynthesis" EXACT [GOC:mah] synonym: "cellular modified amino acid formation" EXACT [GOC:mah] synonym: "cellular modified amino acid synthesis" EXACT [GOC:mah] is_a: GO:0006575 ! modified amino acid metabolic process is_a: GO:0009058 ! biosynthetic process intersection_of: GO:0009058 ! biosynthetic process intersection_of: RO:0004008 CHEBI:83821 ! has primary output relationship: RO:0004008 CHEBI:83821 ! has primary output property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/28908" xsd:anyURI [Term] id: GO:0042401 name: biogenic amine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways occurring at the level of individual cells resulting in the formation of any of a group of naturally occurring, biologically active amines, such as norepinephrine, histamine, and serotonin, many of which act as neurotransmitters." [GOC:jl, ISBN:0395825172] synonym: "biogenic amine anabolism" EXACT [] synonym: "biogenic amine biosynthesis" EXACT [] synonym: "biogenic amine formation" EXACT [] synonym: "biogenic amine synthesis" EXACT [] synonym: "cellular biogenic amine biosynthetic process" EXACT [] is_a: GO:0006576 ! biogenic amine metabolic process is_a: GO:0009309 ! amine biosynthetic process [Term] id: GO:0042402 name: biogenic amine catabolic process namespace: biological_process def: "The chemical reactions and pathways occurring at the level of individual cells resulting in the breakdown of biogenic amines, any of a group of naturally occurring, biologically active amines, such as norepinephrine, histamine, and serotonin, many of which act as neurotransmitters." [GOC:go_curators, GOC:jl, ISBN:0198506732] synonym: "biogenic amine breakdown" EXACT [] synonym: "biogenic amine catabolism" EXACT [] synonym: "biogenic amine degradation" EXACT [] is_a: GO:0009310 ! amine catabolic process property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/28908" xsd:anyURI [Term] id: GO:0042403 name: thyroid hormone metabolic process namespace: biological_process def: "The chemical reactions and pathways involving any of the compounds secreted by the thyroid gland, largely thyroxine and triiodothyronine." [GOC:jl, ISBN:0198506732] synonym: "thyroid hormone metabolism" EXACT [] xref: Reactome:R-HSA-350864 "Regulation of thyroid hormone activity" is_a: GO:0006575 ! modified amino acid metabolic process is_a: GO:0018958 ! phenol-containing compound metabolic process is_a: GO:0042445 ! hormone metabolic process property_value: RO:0002161 NCBITaxon:4895 [Term] id: GO:0042414 name: epinephrine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving epinephrine, a hormone produced by the medulla of the adrenal glands that increases heart activity, improves the power and prolongs the action of muscles, and increases the rate and depth of breathing. It is synthesized by the methylation of norepinephrine." [GOC:jl, ISBN:0192801023, ISBN:0198506732] synonym: "adrenaline metabolic process" EXACT [] synonym: "adrenaline metabolism" EXACT [] synonym: "epinephrine metabolism" EXACT [] is_a: GO:0006584 ! catecholamine metabolic process intersection_of: GO:0008152 ! metabolic process intersection_of: RO:0004007 CHEBI:71406 ! has primary input or output relationship: RO:0004007 CHEBI:71406 ! has primary input or output [Term] id: GO:0042415 name: norepinephrine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving norepinephrine, a hormone secreted by the adrenal medulla, and a neurotransmitter in the sympathetic peripheral nervous system and in some tracts in the central nervous system. It is also the demethylated biosynthetic precursor of epinephrine." [GOC:jl, ISBN:0198506732] synonym: "levarterenol metabolic process" EXACT [] synonym: "levarterenol metabolism" EXACT [] synonym: "noradrenaline metabolic process" EXACT [] synonym: "noradrenaline metabolism" EXACT [] synonym: "norepinephrine metabolism" EXACT [] is_a: GO:0006584 ! catecholamine metabolic process intersection_of: GO:0008152 ! metabolic process intersection_of: RO:0004007 CHEBI:72587 ! has primary input or output relationship: RO:0004007 CHEBI:72587 ! has primary input or output [Term] id: GO:0042416 name: dopamine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of dopamine, a catecholamine neurotransmitter and a metabolic precursor of noradrenaline and adrenaline." [GOC:jl, ISBN:0198506732] synonym: "dopamine anabolism" EXACT [] synonym: "dopamine biosynthesis" EXACT [] synonym: "dopamine formation" EXACT [] synonym: "dopamine synthesis" EXACT [] is_a: GO:0042417 ! dopamine metabolic process is_a: GO:0042423 ! catecholamine biosynthetic process intersection_of: GO:0009058 ! biosynthetic process intersection_of: RO:0004008 CHEBI:59905 ! has primary output relationship: RO:0004008 CHEBI:59905 ! has primary output property_value: RO:0002161 NCBITaxon:4751 [Term] id: GO:0042417 name: dopamine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving dopamine, a catecholamine neurotransmitter and a metabolic precursor of noradrenaline and adrenaline." [GOC:jl, ISBN:0198506732] synonym: "dopamine metabolism" EXACT [] is_a: GO:0006584 ! catecholamine metabolic process intersection_of: GO:0008152 ! metabolic process intersection_of: RO:0004007 CHEBI:59905 ! has primary input or output relationship: RO:0004007 CHEBI:59905 ! has primary input or output property_value: RO:0002161 NCBITaxon:4751 [Term] id: GO:0042418 name: epinephrine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of epinephrine, a hormone produced by the medulla of the adrenal glands that increases heart activity, improves the power and prolongs the action of muscles, and increases the rate and depth of breathing. It is synthesized by the methylation of norepinephrine." [GOC:jl, ISBN:0192801023, ISBN:0198506732] synonym: "adrenaline biosynthesis" EXACT [] synonym: "adrenaline biosynthetic process" EXACT [] synonym: "epinephrine anabolism" EXACT [] synonym: "epinephrine biosynthesis" EXACT [] synonym: "epinephrine formation" EXACT [] synonym: "epinephrine synthesis" EXACT [] is_a: GO:0042414 ! epinephrine metabolic process is_a: GO:0042423 ! catecholamine biosynthetic process intersection_of: GO:0009058 ! biosynthetic process intersection_of: RO:0004008 CHEBI:71406 ! has primary output relationship: RO:0004008 CHEBI:71406 ! has primary output [Term] id: GO:0042419 name: epinephrine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of epinephrine, a hormone produced by the medulla of the adrenal glands that increases heart activity, improves the power and prolongs the action of muscles, and increases the rate and depth of breathing. It is synthesized by the methylation of norepinephrine." [GOC:jl, ISBN:0192801023, ISBN:0198506732] synonym: "adrenaline catabolic process" EXACT [] synonym: "adrenaline catabolism" EXACT [] synonym: "epinephrine breakdown" EXACT [] synonym: "epinephrine catabolism" EXACT [] synonym: "epinephrine degradation" EXACT [] is_a: GO:0042414 ! epinephrine metabolic process is_a: GO:0042424 ! catecholamine catabolic process intersection_of: GO:0009056 ! catabolic process intersection_of: RO:0004009 CHEBI:71406 ! has primary input relationship: RO:0004009 CHEBI:71406 ! has primary input [Term] id: GO:0042420 name: dopamine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of dopamine, a catecholamine neurotransmitter and a metabolic precursor of noradrenaline and adrenaline." [GOC:jl, ISBN:0198506732] synonym: "dopamine breakdown" EXACT [] synonym: "dopamine catabolism" EXACT [] synonym: "dopamine degradation" EXACT [] xref: Reactome:R-HSA-379397 "Enzymatic degradation of dopamine by COMT" xref: Reactome:R-HSA-379398 "Enzymatic degradation of Dopamine by monoamine oxidase" is_a: GO:0042417 ! dopamine metabolic process is_a: GO:0042424 ! catecholamine catabolic process intersection_of: GO:0009056 ! catabolic process intersection_of: RO:0004009 CHEBI:59905 ! has primary input relationship: RO:0004009 CHEBI:59905 ! has primary input property_value: RO:0002161 NCBITaxon:4751 [Term] id: GO:0042421 name: norepinephrine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of norepinephrine, a hormone secreted by the adrenal medulla, and a neurotransmitter in the sympathetic peripheral nervous system and in some tracts in the central nervous system. It is also the demethylated biosynthetic precursor of epinephrine." [GOC:jl, ISBN:0198506732] synonym: "levarterenol biosynthesis" EXACT [] synonym: "levarterenol biosynthetic process" EXACT [] synonym: "noradrenaline biosynthesis" EXACT [] synonym: "noradrenaline biosynthetic process" EXACT [] synonym: "norepinephrine anabolism" EXACT [] synonym: "norepinephrine biosynthesis" EXACT [] synonym: "norepinephrine formation" EXACT [] synonym: "norepinephrine synthesis" EXACT [] is_a: GO:0042415 ! norepinephrine metabolic process is_a: GO:0042423 ! catecholamine biosynthetic process intersection_of: GO:0009058 ! biosynthetic process intersection_of: RO:0004008 CHEBI:72587 ! has primary output relationship: RO:0004008 CHEBI:72587 ! has primary output [Term] id: GO:0042422 name: norepinephrine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of norepinephrine, a hormone secreted by the adrenal medulla, and a neurotransmitter in the sympathetic peripheral nervous system and in some tracts in the central nervous system. It is also the demethylated biosynthetic precursor of epinephrine." [GOC:jl, ISBN:0198506732] synonym: "levarterenol catabolic process" EXACT [] synonym: "levarterenol catabolism" EXACT [] synonym: "noradrenaline catabolic process" EXACT [] synonym: "noradrenaline catabolism" EXACT [] synonym: "norepinephrine breakdown" EXACT [] synonym: "norepinephrine catabolism" EXACT [] synonym: "norepinephrine degradation" EXACT [] xref: Wikipedia:Norepinephrine#Degradation is_a: GO:0042415 ! norepinephrine metabolic process is_a: GO:0042424 ! catecholamine catabolic process intersection_of: GO:0009056 ! catabolic process intersection_of: RO:0004009 CHEBI:72587 ! has primary input relationship: RO:0004009 CHEBI:72587 ! has primary input [Term] id: GO:0042423 name: catecholamine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of any of a group of physiologically important biogenic amines that possess a catechol (3,4-dihydroxyphenyl) nucleus and are derivatives of 3,4-dihydroxyphenylethylamine." [GOC:jl, ISBN:0198506732] synonym: "catecholamine anabolism" EXACT [] synonym: "catecholamine biosynthesis" EXACT [] synonym: "catecholamine formation" EXACT [] synonym: "catecholamine synthesis" EXACT [] xref: Reactome:R-HSA-209905 "Catecholamine biosynthesis" xref: Wikipedia:Catecholamines is_a: GO:0006584 ! catecholamine metabolic process is_a: GO:0009713 ! catechol-containing compound biosynthetic process is_a: GO:0042401 ! biogenic amine biosynthetic process intersection_of: GO:0009058 ! biosynthetic process intersection_of: RO:0004008 CHEBI:33567 ! has primary output relationship: RO:0004008 CHEBI:33567 ! has primary output [Term] id: GO:0042424 name: catecholamine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of any of a group of physiologically important biogenic amines that possess a catechol (3,4-dihydroxyphenyl) nucleus and are derivatives of 3,4-dihydroxyphenylethylamine." [GOC:jl, ISBN:0198506732] synonym: "catecholamine breakdown" EXACT [] synonym: "catecholamine catabolism" EXACT [] synonym: "catecholamine degradation" EXACT [] is_a: GO:0006584 ! catecholamine metabolic process is_a: GO:0019614 ! catechol-containing compound catabolic process is_a: GO:0042402 ! biogenic amine catabolic process intersection_of: GO:0009056 ! catabolic process intersection_of: RO:0004009 CHEBI:33567 ! has primary input relationship: RO:0004009 CHEBI:33567 ! has primary input [Term] id: GO:0042427 name: serotonin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of serotonin (5-hydroxytryptamine), a monoamine neurotransmitter occurring in the peripheral and central nervous systems, also having hormonal properties." [GOC:jl, ISBN:0198506732] synonym: "serotonin anabolism" EXACT [] synonym: "serotonin biosynthesis" EXACT [] synonym: "serotonin formation" EXACT [] synonym: "serotonin synthesis" EXACT [] xref: Wikipedia:Serotonin is_a: GO:0042428 ! serotonin metabolic process is_a: GO:0042435 ! indole-containing compound biosynthetic process is_a: GO:0046189 ! phenol-containing compound biosynthetic process is_a: GO:1901162 ! primary amino compound biosynthetic process intersection_of: GO:0009058 ! biosynthetic process intersection_of: RO:0004008 CHEBI:350546 ! has primary output relationship: RO:0004008 CHEBI:350546 ! has primary output [Term] id: GO:0042428 name: serotonin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving serotonin (5-hydroxytryptamine), a monoamine neurotransmitter occurring in the peripheral and central nervous systems, also having hormonal properties." [GOC:jl, ISBN:0198506732] synonym: "serotonin metabolism" EXACT [] is_a: GO:0018958 ! phenol-containing compound metabolic process is_a: GO:0042430 ! indole-containing compound metabolic process intersection_of: GO:0008152 ! metabolic process intersection_of: RO:0004007 CHEBI:350546 ! has primary input or output relationship: RO:0004007 CHEBI:350546 ! has primary input or output property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/30537" xsd:anyURI [Term] id: GO:0042429 name: serotonin catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of serotonin (5-hydroxytryptamine), a monoamine neurotransmitter occurring in the peripheral and central nervous systems, also having hormonal properties." [GOC:jl, ISBN:0198506732] synonym: "serotonin breakdown" EXACT [] synonym: "serotonin catabolism" EXACT [] synonym: "serotonin degradation" EXACT [] xref: Reactome:R-HSA-380612 "Metabolism of serotonin" is_a: GO:0019336 ! phenol-containing compound catabolic process is_a: GO:0042428 ! serotonin metabolic process is_a: GO:0042436 ! indole-containing compound catabolic process is_a: GO:1901161 ! primary amino compound catabolic process intersection_of: GO:0009056 ! catabolic process intersection_of: RO:0004009 CHEBI:350546 ! has primary input relationship: RO:0004009 CHEBI:350546 ! has primary input [Term] id: GO:0042430 name: indole-containing compound metabolic process namespace: biological_process def: "The chemical reactions and pathways involving compounds that contain an indole (2,3-benzopyrrole) skeleton." [GOC:jl, GOC:mah] synonym: "indole and derivative metabolic process" EXACT [] synonym: "indole and derivative metabolism" EXACT [] synonym: "indole derivative metabolic process" NARROW [] synonym: "indole derivative metabolism" NARROW [] synonym: "indole-containing compound metabolism" EXACT [] synonym: "ketole metabolic process" EXACT [] synonym: "ketole metabolism" EXACT [] is_a: BFO:0000003 is_a: GO:0008152 ! metabolic process intersection_of: GO:0008152 ! metabolic process intersection_of: RO:0004007 CHEBI:24828 ! has primary input or output relationship: RO:0004007 CHEBI:24828 ! has primary input or output [Term] id: GO:0042435 name: indole-containing compound biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of compounds that contain an indole (2,3-benzopyrrole) skeleton." [GOC:jl] synonym: "indole derivative biosynthesis" EXACT [] synonym: "indole derivative biosynthetic process" EXACT [] synonym: "indole-containing compound anabolism" EXACT [] synonym: "indole-containing compound biosynthesis" EXACT [] synonym: "indole-containing compound formation" EXACT [] synonym: "indole-containing compound synthesis" EXACT [] is_a: GO:0009058 ! biosynthetic process is_a: GO:0042430 ! indole-containing compound metabolic process intersection_of: GO:0009058 ! biosynthetic process intersection_of: RO:0004008 CHEBI:24828 ! has primary output relationship: RO:0004008 CHEBI:24828 ! has primary output [Term] id: GO:0042436 name: indole-containing compound catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of compounds that contain an indole (2,3-benzopyrrole) skeleton." [GOC:jl] synonym: "indole derivative catabolic process" EXACT [] synonym: "indole derivative catabolism" EXACT [] synonym: "indole-containing compound breakdown" EXACT [] synonym: "indole-containing compound catabolism" EXACT [] synonym: "indole-containing compound degradation" EXACT [] is_a: GO:0009056 ! catabolic process is_a: GO:0042430 ! indole-containing compound metabolic process intersection_of: GO:0009056 ! catabolic process intersection_of: RO:0004009 CHEBI:24828 ! has primary input relationship: RO:0004009 CHEBI:24828 ! has primary input [Term] id: GO:0042440 name: pigment metabolic process namespace: biological_process def: "The chemical reactions and pathways involving pigment, any general or particular coloring matter in living organisms, e.g. melanin." [GOC:jl, ISBN:0198506732] subset: goslim_drosophila subset: goslim_pir synonym: "pigment metabolism" EXACT [] is_a: GO:0008152 ! metabolic process [Term] id: GO:0042442 name: melatonin catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of melatonin (N-acetyl-5-methoxytryptamine)." [GOC:jl] synonym: "melatonin breakdown" EXACT [] synonym: "melatonin catabolism" EXACT [] synonym: "melatonin degradation" EXACT [] is_a: GO:0030186 ! melatonin metabolic process is_a: GO:0042436 ! indole-containing compound catabolic process is_a: GO:0042447 ! hormone catabolic process intersection_of: GO:0009056 ! catabolic process intersection_of: RO:0004009 CHEBI:16796 ! has primary input relationship: RO:0004009 CHEBI:16796 ! has primary input property_value: RO:0002161 NCBITaxon:4895 [Term] id: GO:0042445 name: hormone metabolic process namespace: biological_process def: "The chemical reactions and pathways involving any hormone, naturally occurring substances secreted by specialized cells that affects the metabolism or behavior of other cells possessing functional receptors for the hormone." [GOC:jl] subset: goslim_pir synonym: "cellular hormone metabolic process" RELATED [] synonym: "hormone metabolism" EXACT [] is_a: GO:0008152 ! metabolic process is_a: GO:0010817 ! regulation of hormone levels property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/23965" xsd:anyURI property_value: RO:0002161 NCBITaxon:4895 [Term] id: GO:0042446 name: hormone biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of any hormone, naturally occurring substances secreted by specialized cells that affects the metabolism or behavior of other cells possessing functional receptors for the hormone." [GOC:jl] synonym: "hormone anabolism" EXACT [] synonym: "hormone biosynthesis" EXACT [] synonym: "hormone formation" EXACT [] synonym: "hormone synthesis" EXACT [] is_a: GO:0009058 ! biosynthetic process is_a: GO:0042445 ! hormone metabolic process property_value: RO:0002161 NCBITaxon:4895 [Term] id: GO:0042447 name: hormone catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of any hormone, naturally occurring substances secreted by specialized cells that affects the metabolism or behavior of other cells possessing functional receptors for the hormone." [GOC:jl] synonym: "hormone breakdown" EXACT [] synonym: "hormone catabolism" EXACT [] synonym: "hormone degradation" EXACT [] is_a: GO:0009056 ! catabolic process is_a: GO:0042445 ! hormone metabolic process property_value: RO:0002161 NCBITaxon:4895 [Term] id: GO:0042448 name: progesterone metabolic process namespace: biological_process def: "The chemical reactions and pathways involving progesterone, a steroid hormone produced in the ovary which prepares and maintains the uterus for pregnancy. Also found in plants." [GOC:jl, PMID:11392024] synonym: "progesterone metabolism" EXACT [] is_a: GO:0008207 ! C21-steroid hormone metabolic process is_a: GO:0042180 ! ketone metabolic process is_a: GO:0120254 ! olefinic compound metabolic process intersection_of: GO:0008152 ! metabolic process intersection_of: RO:0004007 CHEBI:17026 ! has primary input or output relationship: RO:0004007 CHEBI:17026 ! has primary input or output property_value: RO:0002161 NCBITaxon:4895 [Term] id: GO:0042461 name: photoreceptor cell development namespace: biological_process def: "Development of a photoreceptor, a cell that responds to incident electromagnetic radiation, particularly visible light." [GOC:go_curators] synonym: "photoreceptor morphogenesis" EXACT [] is_a: GO:0048666 ! neuron development intersection_of: GO:0032502 ! developmental process intersection_of: RO:0002296 CL:0000210 ! results in development of photoreceptor cell relationship: BFO:0000050 GO:0046530 ! part of photoreceptor cell differentiation relationship: RO:0002296 CL:0000210 ! results in development of photoreceptor cell [Term] id: GO:0042462 name: eye photoreceptor cell development namespace: biological_process def: "Development of a photoreceptor, a sensory cell in the eye that reacts to the presence of light. They usually contain a pigment that undergoes a chemical change when light is absorbed, thus stimulating a nerve." [GOC:jl, ISBN:0192800981] is_a: GO:0042461 ! photoreceptor cell development intersection_of: GO:0032502 ! developmental process intersection_of: RO:0002296 CL:0000287 ! results in development of eye photoreceptor cell relationship: BFO:0000050 GO:0001754 ! part of eye photoreceptor cell differentiation relationship: RO:0002296 CL:0000287 ! results in development of eye photoreceptor cell [Term] id: GO:0042470 name: melanosome namespace: cellular_component def: "A tissue-specific, membrane-bounded cytoplasmic organelle within which melanin pigments are synthesized and stored. Melanosomes are synthesized in melanocyte cells." [GOC:jl, PMID:11584301] xref: Wikipedia:Melanosome is_a: GO:0048770 ! pigment granule relationship: BFO:0000050 CL:0000148 ! part of melanocyte [Term] id: GO:0042471 name: ear morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the ear are generated and organized. The ear is the sense organ in vertebrates that is specialized for the detection of sound, and the maintenance of balance. Includes the outer ear and middle ear, which collect and transmit sound waves; and the inner ear, which contains the organs of balance and (except in fish) hearing. Also includes the pinna, the visible part of the outer ear, present in some mammals." [GOC:jl, ISBN:0192801023] synonym: "hearing organ morphogenesis" EXACT [] is_a: GO:0048562 ! embryonic organ morphogenesis is_a: GO:0090596 ! sensory organ morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0001690 ! results in morphogenesis of ear relationship: BFO:0000050 GO:0043583 ! part of ear development relationship: RO:0002298 UBERON:0001690 ! results in morphogenesis of ear [Term] id: GO:0042472 name: inner ear morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the inner ear are generated and organized. The inner ear is the structure in vertebrates that contains the organs of balance and hearing. It consists of soft hollow sensory structures (the membranous labyrinth) containing fluid (endolymph) surrounded by fluid (perilymph) and encased in a bony cavity (the bony labyrinth). It consists of two chambers, the sacculus and utriculus, from which arise the cochlea and semicircular canals respectively." [GOC:jl, ISBN:0192801023] is_a: BFO:0000003 is_a: GO:0048598 ! embryonic morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0001846 ! results in morphogenesis of internal ear relationship: BFO:0000050 GO:0042471 ! part of ear morphogenesis relationship: BFO:0000050 GO:0048839 ! part of inner ear development relationship: RO:0002298 UBERON:0001846 ! results in morphogenesis of internal ear [Term] id: GO:0042473 name: outer ear morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the outer ear are generated and organized. The outer ear is the part of the ear external to the tympanum (eardrum). It consists of a tube (the external auditory meatus) that directs sound waves on to the tympanum, and may also include the external pinna, which extends beyond the skull." [GOC:jl, ISBN:0192801023] is_a: BFO:0000003 is_a: GO:0048598 ! embryonic morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0001691 ! results in morphogenesis of external ear relationship: BFO:0000050 GO:0042471 ! part of ear morphogenesis relationship: RO:0002298 UBERON:0001691 ! results in morphogenesis of external ear [Term] id: GO:0042474 name: middle ear morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the middle ear are generated and organized. The middle ear is the air-filled cavity within the skull of vertebrates that lies between the outer ear and the inner ear. It is linked to the pharynx (and therefore to outside air) via the Eustachian tube and in mammals contains the three ear ossicles, which transmit auditory vibrations from the outer ear (via the tympanum) to the inner ear (via the oval window)." [GOC:jl, ISBN:0192801023] is_a: BFO:0000003 is_a: GO:0048598 ! embryonic morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0001756 ! results in morphogenesis of middle ear relationship: BFO:0000050 GO:0042471 ! part of ear morphogenesis relationship: RO:0002298 UBERON:0001756 ! results in morphogenesis of middle ear [Term] id: GO:0042475 name: odontogenesis of dentin-containing tooth namespace: biological_process def: "The process whose specific outcome is the progression of a dentin-containing tooth over time, from its formation to the mature structure. A dentin-containing tooth is a hard, bony organ borne on the jaw or other bone of a vertebrate, and is composed mainly of dentin, a dense calcified substance, covered by a layer of enamel." [GOC:cjm, GOC:mah, GOC:mtg_sensu, PMID:10333884, PMID:15355794] comment: Note that placoid scales found in the cartilaginous fishes presumably develop through the same processes, but are found on the dermis, rather than in the mouth or pharynx. See Wikipedia:Placoid_scale#Placoid_scales. synonym: "odontogenesis of dentine-containing teeth" EXACT [] synonym: "odontogenesis of dentine-containing tooth" EXACT [GOC:mah] synonym: "odontogeny" BROAD [] synonym: "odontosis" BROAD [] synonym: "tooth development" BROAD [] is_a: GO:0042476 ! odontogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0001091 ! results in morphogenesis of calcareous tooth relationship: RO:0002298 UBERON:0001091 ! results in morphogenesis of calcareous tooth property_value: RO:0002161 NCBITaxon:8782 [Term] id: GO:0042476 name: odontogenesis namespace: biological_process def: "The process whose specific outcome is the progression of a tooth or teeth over time, from formation to the mature structure(s). A tooth is any hard bony, calcareous, or chitinous organ found in the mouth or pharynx of an animal and used in procuring or masticating food." [GOC:jl, GOC:mah] synonym: "odontogenesis of calcareous or chitinous tooth" NARROW [] synonym: "odontogeny" EXACT [] synonym: "odontosis" EXACT [] synonym: "tooth development" RELATED [] synonym: "tooth morphogenesis" EXACT [] xref: Wikipedia:Odontogenesis is_a: GO:0009887 ! animal organ morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0003913 ! results in morphogenesis of tooth-like structure relationship: RO:0002162 NCBITaxon:33213 ! in taxon Bilateria relationship: RO:0002298 UBERON:0003913 ! results in morphogenesis of tooth-like structure property_value: RO:0002161 NCBITaxon:8782 [Term] id: GO:0042478 name: regulation of eye photoreceptor cell development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of eye photoreceptor development." [GOC:jl] synonym: "regulation of eye photoreceptor development" EXACT [] is_a: GO:0046532 ! regulation of photoreceptor cell differentiation is_a: GO:0060284 ! regulation of cell development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0042462 ! regulates eye photoreceptor cell development relationship: RO:0002211 GO:0042462 ! regulates eye photoreceptor cell development [Term] id: GO:0042479 name: positive regulation of eye photoreceptor cell development namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of eye photoreceptor development." [GOC:jl] synonym: "activation of eye photoreceptor cell development" NARROW [] synonym: "positive regulation of eye photoreceptor development" EXACT [] synonym: "stimulation of eye photoreceptor cell development" NARROW [] synonym: "up regulation of eye photoreceptor cell development" EXACT [] synonym: "up-regulation of eye photoreceptor cell development" EXACT [] synonym: "upregulation of eye photoreceptor cell development" EXACT [] is_a: GO:0010720 ! positive regulation of cell development is_a: GO:0042478 ! regulation of eye photoreceptor cell development is_a: GO:0046534 ! positive regulation of photoreceptor cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0042462 ! positively regulates eye photoreceptor cell development relationship: RO:0002213 GO:0042462 ! positively regulates eye photoreceptor cell development [Term] id: GO:0042480 name: negative regulation of eye photoreceptor cell development namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of eye photoreceptor development." [GOC:jl] synonym: "down regulation of eye photoreceptor cell development" EXACT [] synonym: "down-regulation of eye photoreceptor cell development" EXACT [] synonym: "downregulation of eye photoreceptor cell development" EXACT [] synonym: "inhibition of eye photoreceptor cell development" NARROW [] synonym: "negative regulation of eye photoreceptor development" EXACT [] is_a: GO:0010721 ! negative regulation of cell development is_a: GO:0042478 ! regulation of eye photoreceptor cell development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0042462 ! negatively regulates eye photoreceptor cell development relationship: RO:0002212 GO:0042462 ! negatively regulates eye photoreceptor cell development [Term] id: GO:0042481 name: regulation of odontogenesis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the formation and development of a tooth or teeth." [GOC:jl] synonym: "regulation of odontogenesis of calcareous or chitinous tooth" NARROW [] synonym: "regulation of tooth development" EXACT [] is_a: GO:2000027 ! regulation of animal organ morphogenesis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0042476 ! regulates odontogenesis relationship: RO:0002211 GO:0042476 ! regulates odontogenesis property_value: RO:0002161 NCBITaxon:8782 [Term] id: GO:0042482 name: positive regulation of odontogenesis namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the formation and development of a tooth or teeth." [GOC:jl] synonym: "activation of odontogenesis" NARROW [] synonym: "positive regulation of odontogenesis of calcareous or chitinous tooth" NARROW [] synonym: "positive regulation of tooth development" EXACT [] synonym: "stimulation of odontogenesis" NARROW [] synonym: "up regulation of odontogenesis" EXACT [] synonym: "up-regulation of odontogenesis" EXACT [] synonym: "upregulation of odontogenesis" EXACT [] is_a: GO:0042481 ! regulation of odontogenesis is_a: GO:0110110 ! positive regulation of animal organ morphogenesis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0042476 ! positively regulates odontogenesis relationship: RO:0002213 GO:0042476 ! positively regulates odontogenesis property_value: RO:0002161 NCBITaxon:8782 [Term] id: GO:0042483 name: negative regulation of odontogenesis namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the formation and development of a tooth or teeth." [GOC:jl] synonym: "down regulation of odontogenesis" EXACT [] synonym: "down-regulation of odontogenesis" EXACT [] synonym: "downregulation of odontogenesis" EXACT [] synonym: "inhibition of odontogenesis" NARROW [] synonym: "negative regulation of odontogenesis of calcareous or chitinous tooth" NARROW [] synonym: "negative regulation of tooth development" EXACT [] is_a: GO:0042481 ! regulation of odontogenesis is_a: GO:0110111 ! negative regulation of animal organ morphogenesis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0042476 ! negatively regulates odontogenesis relationship: RO:0002212 GO:0042476 ! negatively regulates odontogenesis property_value: RO:0002161 NCBITaxon:8782 [Term] id: GO:0042487 name: regulation of odontogenesis of dentin-containing tooth namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the formation and development of teeth, the hard, bony appendages which are borne on the jaws, or on other bones in the walls of the mouth or pharynx of most vertebrates." [GOC:jl, GOC:mtg_sensu, PMID:15355794] synonym: "regulation of odontogenesis of dentine-containing teeth" EXACT [] synonym: "regulation of odontogenesis of dentine-containing tooth" EXACT [GOC:mah] is_a: GO:0042481 ! regulation of odontogenesis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0042475 ! regulates odontogenesis of dentin-containing tooth relationship: RO:0002211 GO:0042475 ! regulates odontogenesis of dentin-containing tooth property_value: RO:0002161 NCBITaxon:8782 [Term] id: GO:0042488 name: positive regulation of odontogenesis of dentin-containing tooth namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the formation and development of teeth, the hard, bony appendages that are borne on the jaws, or on other bones in the walls of the mouth or pharynx of most vertebrates." [GOC:jl, PMID:15355794] synonym: "activation of odontogenesis" BROAD [] synonym: "positive regulation of odontogenesis of dentine-containing teeth" EXACT [] synonym: "positive regulation of odontogenesis of dentine-containing tooth" RELATED [] synonym: "stimulation of odontogenesis" BROAD [] synonym: "up regulation of odontogenesis" BROAD [] synonym: "up-regulation of odontogenesis" BROAD [] synonym: "upregulation of odontogenesis" BROAD [] is_a: GO:0042482 ! positive regulation of odontogenesis is_a: GO:0042487 ! regulation of odontogenesis of dentin-containing tooth intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0042475 ! positively regulates odontogenesis of dentin-containing tooth relationship: RO:0002213 GO:0042475 ! positively regulates odontogenesis of dentin-containing tooth property_value: RO:0002161 NCBITaxon:8782 [Term] id: GO:0042489 name: negative regulation of odontogenesis of dentin-containing tooth namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the formation and development of teeth, the hard, bony appendages which are borne on the jaws, or on other bones in the walls of the mouth or pharynx." [GOC:jl, GOC:mtg_sensu, PMID:15355794] synonym: "down regulation of odontogenesis" BROAD [] synonym: "down-regulation of odontogenesis" BROAD [] synonym: "downregulation of odontogenesis" BROAD [] synonym: "inhibition of odontogenesis" BROAD [] synonym: "negative regulation of odontogenesis" BROAD [] synonym: "negative regulation of odontogenesis of dentine-containing teeth" EXACT [] synonym: "negative regulation of odontogenesis of dentine-containing tooth" RELATED [] is_a: GO:0042483 ! negative regulation of odontogenesis is_a: GO:0042487 ! regulation of odontogenesis of dentin-containing tooth intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0042475 ! negatively regulates odontogenesis of dentin-containing tooth relationship: RO:0002212 GO:0042475 ! negatively regulates odontogenesis of dentin-containing tooth property_value: RO:0002161 NCBITaxon:8782 [Term] id: GO:0042490 name: mechanoreceptor differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a mechanoreceptor, a cell specialized to transduce mechanical stimuli and relay that information centrally in the nervous system." [CL:0000199, GOC:jl] is_a: GO:0030182 ! neuron differentiation [Term] id: GO:0042491 name: inner ear auditory receptor cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized inner cell acquires specialized features of an auditory hair cell." [CL:0000201, GOC:jl] comment: Note that this term refers to the mechanosensory hair cells of the inner ear. synonym: "auditory hair cell differentiation" EXACT [] synonym: "auditory receptor cell differentiation" RELATED [] is_a: GO:0035315 ! hair cell differentiation is_a: GO:0060113 ! inner ear receptor cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000202 ! results in acquisition of features of auditory hair cell relationship: RO:0002315 CL:0000202 ! results in acquisition of features of auditory hair cell [Term] id: GO:0042492 name: gamma-delta T cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized hemopoietic cell acquires specialized features of a gamma-delta T cell. A gamma-delta T cell is a T cell that expresses a gamma-delta T cell receptor complex." [CL:0000798, GOC:jl] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "gamma-delta T cell development" RELATED [GOC:add] synonym: "gamma-delta T lymphocyte differentiation" EXACT [] synonym: "gamma-delta T-cell differentiation" EXACT [] synonym: "gamma-delta T-lymphocyte differentiation" EXACT [] is_a: GO:0030217 ! T cell differentiation is_a: GO:0046629 ! gamma-delta T cell activation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000798 ! results in acquisition of features of gamma-delta T cell relationship: RO:0002315 CL:0000798 ! results in acquisition of features of gamma-delta T cell [Term] id: GO:0042551 name: neuron maturation namespace: biological_process def: "A developmental process, independent of morphogenetic (shape) change, that is required for a neuron to attain its fully functional state." [GOC:dph, GOC:jl] is_a: GO:0048469 ! cell maturation intersection_of: GO:0021700 ! developmental maturation intersection_of: RO:0002299 CL:0000540 ! results in maturation of neuron relationship: BFO:0000050 GO:0048666 ! part of neuron development relationship: RO:0002299 CL:0000540 ! results in maturation of neuron [Term] id: GO:0042552 name: myelination namespace: biological_process def: "The process in which myelin sheaths are formed and maintained around neurons. Oligodendrocytes in the brain and spinal cord and Schwann cells in the peripheral nervous system wrap axons with compact layers of their plasma membrane. Adjacent myelin segments are separated by a non-myelinated stretch of axon called a node of Ranvier." [GOC:dgh, GOC:mah] synonym: "myelinogenesis" RELATED [GOC:cjm, HP:0003429] xref: Wikipedia:Myelin is_a: GO:0008366 ! axon ensheathment [Term] id: GO:0042554 name: superoxide anion generation namespace: biological_process def: "The enzymatic generation of superoxide, the superoxide anion O2- (superoxide free radical), or any compound containing this species, by a cell in response to environmental stress, thereby mediating the activation of various stress-inducible signaling pathways." [GOC:jl, PMID:12359750] synonym: "superoxide release" EXACT [GOC:hjd, GOC:mah] is_a: GO:0006801 ! superoxide metabolic process [Term] id: GO:0042562 name: hormone binding namespace: molecular_function def: "Binding to an hormone, a naturally occurring substance secreted by specialized cells that affect the metabolism or behavior of cells possessing functional receptors for the hormone. Hormones may be produced by the same, or different, cell as express the receptor." [GOC:jl] subset: goslim_chembl subset: goslim_pir is_a: GO:0005488 ! binding [Term] id: GO:0042571 name: immunoglobulin complex, circulating namespace: cellular_component def: "An immunoglobulin complex that is secreted into extracellular space and found in mucosal areas or other tissues or circulating in the blood or lymph. In its canonical form, a circulating immunoglobulin complex is composed of two identical heavy chains and two identical light chains, held together by disulfide bonds. Some forms of are polymers of the basic structure and contain additional components such as J-chain and the secretory component." [GOC:add, ISBN:0781735149] comment: Note that an immunoglobulin complex has the function of antigen binding if a suitable antigen is available. synonym: "antibody" EXACT [GOC:add] xref: Wikipedia:Antibody is_a: BFO:0000002 is_a: BFO:0000004 is_a: GO:0019814 ! immunoglobulin complex intersection_of: GO:0019814 ! immunoglobulin complex intersection_of: RO:0002353 GO:0032940 ! output of secretion by cell relationship: BFO:0000050 GO:0005615 ! part of extracellular space relationship: RO:0002353 GO:0032940 ! output of secretion by cell property_value: RO:0002161 NCBITaxon:4890 [Term] id: GO:0042582 name: azurophil granule namespace: cellular_component def: "Primary lysosomal granule readily stainable with a Romanowsky stain." [GOC:jl, PMID:17152095, PMID:28717070, PMID:5914694, WIKIPEDIA:Azurophilic_granule] synonym: "primary granule" EXACT [] is_a: GO:0005766 ! primary lysosome is_a: GO:0030141 ! secretory granule property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/27231" xsd:anyURI property_value: RO:0002161 NCBITaxon:4751 [Term] id: GO:0042585 name: germinal vesicle namespace: cellular_component def: "The enlarged, fluid filled nucleus of a primary oocyte, the development of which is suspended in prophase I of the first meiotic division between embryohood and sexual maturity." [GOC:jl, GOC:mtg_sensu, PMID:19019837] synonym: "primary oocyte nucleus" EXACT [] is_a: GO:0001674 ! female germ cell nucleus intersection_of: GO:0005634 ! nucleus intersection_of: BFO:0000050 CL:0000654 ! part of primary oocyte relationship: BFO:0000050 CL:0000654 ! part of primary oocyte [Term] id: GO:0042588 name: zymogen granule namespace: cellular_component def: "A membrane-bounded, cytoplasmic secretory granule found in enzyme-secreting cells and visible by light microscopy. Contain zymogen, an inactive enzyme precursor, often of a digestive enzyme." [GOC:jl, ISBN:0198506732] is_a: GO:0030141 ! secretory granule property_value: RO:0002161 NCBITaxon:4890 [Term] id: GO:0042589 name: zymogen granule membrane namespace: cellular_component def: "The lipid bilayer surrounding a zymogen granule." [GOC:jl] is_a: GO:0030667 ! secretory granule membrane intersection_of: GO:0016020 ! membrane intersection_of: RO:0002007 GO:0042588 ! bounding layer of zymogen granule relationship: RO:0002007 GO:0042588 ! bounding layer of zymogen granule property_value: RO:0002161 NCBITaxon:4890 [Term] id: GO:0042590 name: antigen processing and presentation of exogenous peptide antigen via MHC class I namespace: biological_process def: "The process in which an antigen-presenting cell expresses a peptide antigen of exogenous origin on its cell surface in association with an MHC class I protein complex. The peptide antigen is typically, but not always, processed from a whole protein. Class I here refers to classical class I molecules." [GOC:add, ISBN:0781735149, PMID:15771591] synonym: "antigen presentation, exogenous antigen via major histocompatibility complex class I" EXACT [] synonym: "antigen presentation, exogenous antigen via MHC class I" EXACT [] synonym: "cross presentation" BROAD [] synonym: "cross priming" BROAD [] synonym: "cross-presentation" BROAD [] synonym: "cross-priming" BROAD [] synonym: "exogenous peptide antigen processing and presentation via MHC class I" EXACT [] xref: Reactome:R-HSA-1236975 "Antigen processing-Cross presentation" is_a: GO:0002474 ! antigen processing and presentation of peptide antigen via MHC class I is_a: GO:0002478 ! antigen processing and presentation of exogenous peptide antigen property_value: RO:0002161 NCBITaxon:4895 [Term] id: GO:0042592 name: homeostatic process namespace: biological_process def: "Any biological process involved in the maintenance of an internal steady state." [GOC:jl, ISBN:0395825172] subset: goslim_agr subset: goslim_chembl subset: goslim_mouse synonym: "activation of homeostatic process" NARROW [] synonym: "homeostasis" EXACT [] synonym: "inhibition of homeostatic process" NARROW [] synonym: "negative regulation of homeostatic process" RELATED [] synonym: "positive regulation of homeostatic process" RELATED [] synonym: "regulation of homeostatic process" RELATED [] is_a: GO:0008150 ! biological_process [Term] id: GO:0042593 name: glucose homeostasis namespace: biological_process def: "Any process involved in the maintenance of an internal steady state of glucose within an organism or cell." [GOC:go_curators] is_a: GO:0033500 ! carbohydrate homeostasis intersection_of: GO:0048878 ! chemical homeostasis intersection_of: RO:0002332 CHEBI:4167 ! regulates levels of relationship: RO:0002332 CHEBI:4167 ! regulates levels of [Term] id: GO:0042599 name: lamellar body namespace: cellular_component def: "A membrane-bounded organelle, specialized for the storage and secretion of various substances (surfactant phospholipids, glycoproteins and acid phosphates) which are arranged in the form of tightly packed, concentric, membrane sheets or lamellae. Has some similar properties to, but is distinct from, a lysosome." [GOC:cjm, GOC:jl, PMID:12243725, Wikipedia:Lamellar_granule] synonym: "keratinosome" NARROW [] synonym: "lamellar granule" EXACT [] synonym: "membrane-coating granule" EXACT [] synonym: "Odland body" NARROW [] xref: NIF_Subcellular:sao1379604862 is_a: GO:0030141 ! secretory granule property_value: RO:0002161 NCBITaxon:4890 [Term] id: GO:0042608 name: T cell receptor binding namespace: molecular_function def: "Binding to a T cell receptor, the antigen-recognizing receptor on the surface of T cells." [GOC:jl] synonym: "T lymphocyte receptor binding" EXACT [] synonym: "T-cell receptor binding" EXACT [] synonym: "T-lymphocyte receptor binding" EXACT [] synonym: "TCR binding" EXACT [] is_a: GO:0005102 ! signaling receptor binding is_a: GO:0044877 ! protein-containing complex binding intersection_of: GO:0005488 ! binding intersection_of: RO:0004009 GO:0042101 ! has primary input T cell receptor complex relationship: RO:0004009 GO:0042101 ! has primary input T cell receptor complex [Term] id: GO:0042611 name: MHC protein complex namespace: cellular_component def: "A transmembrane protein complex composed of an MHC alpha chain and, in most cases, either an MHC class II beta chain or an invariant beta2-microglobin chain, and with or without a bound peptide, lipid, or polysaccharide antigen." [GOC:add, GOC:jl, ISBN:0781735149, PMID:15928678, PMID:16153240] subset: goslim_pir is_a: GO:0098797 ! plasma membrane protein complex [Term] id: GO:0042613 name: MHC class II protein complex namespace: cellular_component def: "A transmembrane protein complex composed of an MHC class II alpha and MHC class II beta chain, and with or without a bound peptide or polysaccharide antigen." [GOC:add, GOC:jl, ISBN:0120781859, PMID:15928678] is_a: GO:0042611 ! MHC protein complex [Term] id: GO:0042629 name: mast cell granule namespace: cellular_component def: "Coarse, bluish-black staining cytoplasmic granules, bounded by a plasma membrane and found in mast cells and basophils. Contents include histamine, heparin, chondroitin sulfates, chymase and tryptase." [GOC:jl, PMID:12360215] is_a: GO:0005764 ! lysosome property_value: RO:0002161 NCBITaxon:4751 [Term] id: GO:0042633 name: hair cycle namespace: biological_process def: "The cyclical phases of growth (anagen), regression (catagen), quiescence (telogen), and shedding (exogen) in the life of a hair; one of the collection or mass of filaments growing from the skin of an animal, and forming a covering for a part of the head or for any part or the whole of the body." [GOC:go_curators, PMID:12230507] is_a: GO:0042303 ! molting cycle relationship: RO:0002162 NCBITaxon:40674 ! in taxon Mammalia [Term] id: GO:0042634 name: regulation of hair cycle namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the cyclical phases of growth (anagen), regression (catagen), quiescence (telogen), and shedding (exogen) in the life of a hair." [GOC:go_curators, PMID:12230507] is_a: GO:0051239 ! regulation of multicellular organismal process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0042633 ! regulates hair cycle relationship: RO:0002211 GO:0042633 ! regulates hair cycle [Term] id: GO:0042635 name: positive regulation of hair cycle namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the cyclical phases of growth (anagen), regression (catagen), quiescence (telogen), and shedding (exogen) in the life of a hair." [GOC:go_curators, PMID:12230507] synonym: "activation of hair cycle" NARROW [] synonym: "stimulation of hair cycle" NARROW [] synonym: "up regulation of hair cycle" EXACT [] synonym: "up-regulation of hair cycle" EXACT [] synonym: "upregulation of hair cycle" EXACT [] is_a: GO:0042634 ! regulation of hair cycle is_a: GO:0051240 ! positive regulation of multicellular organismal process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0042633 ! positively regulates hair cycle relationship: RO:0002213 GO:0042633 ! positively regulates hair cycle [Term] id: GO:0042636 name: negative regulation of hair cycle namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the cyclical phases of growth (anagen), regression (catagen), quiescence (telogen), and shedding (exogen) in the life of a hair." [GOC:go_curators, PMID:12230507] synonym: "down regulation of hair cycle" EXACT [] synonym: "down-regulation of hair cycle" EXACT [] synonym: "downregulation of hair cycle" EXACT [] synonym: "inhibition of hair cycle" NARROW [] is_a: GO:0042634 ! regulation of hair cycle is_a: GO:0051241 ! negative regulation of multicellular organismal process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0042633 ! negatively regulates hair cycle relationship: RO:0002212 GO:0042633 ! negatively regulates hair cycle [Term] id: GO:0042641 name: actomyosin namespace: cellular_component def: "Any complex of actin, myosin, and accessory proteins." [GOC:go_curators] synonym: "actomyosin complex" EXACT [] synonym: "actomyosin structure" EXACT [] is_a: GO:0110165 ! cellular anatomical structure relationship: BFO:0000050 GO:0015629 ! part of actin cytoskeleton [Term] id: GO:0042644 name: chloroplast nucleoid namespace: cellular_component def: "The region of a chloroplast to which the DNA is confined." [GOC:jl] is_a: GO:0042646 ! plastid nucleoid intersection_of: GO:0009295 ! nucleoid intersection_of: BFO:0000050 GO:0009507 ! part of chloroplast relationship: BFO:0000050 GO:0009570 ! part of chloroplast stroma property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:28009 property_value: RO:0002161 NCBITaxon:33208 property_value: RO:0002161 NCBITaxon:4751 property_value: RO:0002161 NCBITaxon:554915 [Term] id: GO:0042645 name: mitochondrial nucleoid namespace: cellular_component def: "The region of a mitochondrion to which the DNA is confined." [GOC:jl] is_a: GO:0009295 ! nucleoid is_a: GO:0043232 ! intracellular membraneless organelle intersection_of: GO:0009295 ! nucleoid intersection_of: BFO:0000050 GO:0005739 ! part of mitochondrion relationship: BFO:0000050 GO:0005759 ! part of mitochondrial matrix [Term] id: GO:0042646 name: plastid nucleoid namespace: cellular_component def: "The region of a plastid to which the DNA is confined." [GOC:jl] is_a: GO:0009295 ! nucleoid is_a: GO:0043232 ! intracellular membraneless organelle intersection_of: GO:0009295 ! nucleoid intersection_of: BFO:0000050 GO:0009536 ! part of plastid relationship: BFO:0000050 GO:0009532 ! part of plastid stroma property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:28009 property_value: RO:0002161 NCBITaxon:33208 property_value: RO:0002161 NCBITaxon:4751 property_value: RO:0002161 NCBITaxon:554915 [Term] id: GO:0042648 name: chloroplast chromosome namespace: cellular_component def: "A circular DNA molecule containing chloroplast encoded genes." [GOC:jl] is_a: GO:0009508 ! plastid chromosome intersection_of: GO:0005694 ! chromosome intersection_of: BFO:0000050 GO:0009507 ! part of chloroplast relationship: BFO:0000050 GO:0042644 ! part of chloroplast nucleoid property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:28009 property_value: RO:0002161 NCBITaxon:33208 property_value: RO:0002161 NCBITaxon:4751 property_value: RO:0002161 NCBITaxon:554915 [Term] id: GO:0042670 name: retinal cone cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires the specialized features of a retinal cone cell." [GOC:go_curators] is_a: GO:0060219 ! camera-type eye photoreceptor cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000573 ! results in acquisition of features of retinal cone cell relationship: RO:0002315 CL:0000573 ! results in acquisition of features of retinal cone cell [Term] id: GO:0042675 name: compound eye cone cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires the specialized features of a compound eye cone cell, a cone-shaped cell, that focuses light in a compound eye." [GOC:mtg_sensu] is_a: GO:0030154 ! cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000718 ! results in acquisition of features of compound eye cone cell relationship: BFO:0000050 GO:0001745 ! part of compound eye morphogenesis relationship: RO:0002315 CL:0000718 ! results in acquisition of features of compound eye cone cell [Term] id: GO:0042688 name: crystal cell differentiation namespace: biological_process def: "The process in which a hemocyte precursor cell acquires the characteristics of a crystal cell, a class of cells that contain crystalline inclusions and are involved in the melanization of pathogenic material in the hemolymph." [GOC:bf, http://sdb.bio.purdue.edu/fly/gene/serpent3.htm] is_a: GO:0042386 ! hemocyte differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000392 ! results in acquisition of features of crystal cell relationship: RO:0002315 CL:0000392 ! results in acquisition of features of crystal cell [Term] id: GO:0042689 name: regulation of crystal cell differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of crystal cell differentiation." [GOC:go_curators] is_a: GO:0045610 ! regulation of hemocyte differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0042688 ! regulates crystal cell differentiation relationship: RO:0002211 GO:0042688 ! regulates crystal cell differentiation [Term] id: GO:0042690 name: negative regulation of crystal cell differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of crystal cell differentiation." [GOC:go_curators] synonym: "down regulation of crystal cell differentiation" EXACT [] synonym: "down-regulation of crystal cell differentiation" EXACT [] synonym: "downregulation of crystal cell differentiation" EXACT [] synonym: "inhibition of crystal cell differentiation" NARROW [] is_a: GO:0042689 ! regulation of crystal cell differentiation is_a: GO:0045611 ! negative regulation of hemocyte differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0042688 ! negatively regulates crystal cell differentiation relationship: RO:0002212 GO:0042688 ! negatively regulates crystal cell differentiation [Term] id: GO:0042691 name: positive regulation of crystal cell differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of crystal cell differentiation." [GOC:go_curators] synonym: "activation of crystal cell differentiation" NARROW [] synonym: "stimulation of crystal cell differentiation" NARROW [] synonym: "up regulation of crystal cell differentiation" EXACT [] synonym: "up-regulation of crystal cell differentiation" EXACT [] synonym: "upregulation of crystal cell differentiation" EXACT [] is_a: GO:0042689 ! regulation of crystal cell differentiation is_a: GO:0045612 ! positive regulation of hemocyte differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0042688 ! positively regulates crystal cell differentiation relationship: RO:0002213 GO:0042688 ! positively regulates crystal cell differentiation [Term] id: GO:0042692 name: muscle cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a muscle cell." [CL:0000187, GOC:go_curators] synonym: "myogenesis" RELATED [] is_a: GO:0030154 ! cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000187 ! results in acquisition of features of muscle cell relationship: BFO:0000050 GO:0061061 ! part of muscle structure development relationship: RO:0002315 CL:0000187 ! results in acquisition of features of muscle cell [Term] id: GO:0042698 name: ovulation cycle namespace: biological_process def: "The type of sexual cycle seen in females, often with physiologic changes in the endometrium that recur at regular intervals during the reproductive years." [ISBN:0721662544] is_a: GO:0048511 ! rhythmic process is_a: GO:0048609 ! multicellular organismal reproductive process relationship: RO:0002162 NCBITaxon:2759 ! in taxon Eukaryota [Term] id: GO:0042701 name: progesterone secretion namespace: biological_process def: "The regulated release of progesterone, a steroid hormone, by the corpus luteum of the ovary and by the placenta." [GOC:jl, ISBN:0395825172] is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism is_a: GO:0022602 ! ovulation cycle process is_a: GO:0035929 ! steroid hormone secretion intersection_of: GO:0046903 ! secretion intersection_of: RO:0004009 CHEBI:17026 ! has primary input relationship: BFO:0000050 GO:0001553 ! part of luteinization relationship: RO:0004009 CHEBI:17026 ! has primary input [Term] id: GO:0042702 name: uterine wall growth namespace: biological_process def: "The regrowth of the endometrium and blood vessels in the uterus following menstruation, resulting from a rise in progesterone levels." [GOC:jl] is_a: BFO:0000003 is_a: GO:0022602 ! ovulation cycle process is_a: GO:0048589 ! developmental growth intersection_of: GO:0040007 ! growth intersection_of: RO:0002343 UBERON:0000459 ! results in growth of uterine wall relationship: BFO:0000050 GO:0001553 ! part of luteinization relationship: RO:0002162 NCBITaxon:32525 ! in taxon Theria relationship: RO:0002343 UBERON:0000459 ! results in growth of uterine wall [Term] id: GO:0042713 name: sperm ejaculation namespace: biological_process def: "The expulsion of seminal fluid, thick white fluid containing spermatozoa, from the male genital tract." [GOC:jl, PMID:26385403] is_a: GO:0048609 ! multicellular organismal reproductive process relationship: BFO:0000050 GO:0007320 ! part of insemination [Term] id: GO:0042742 name: defense response to bacterium namespace: biological_process def: "Reactions triggered in response to the presence of a bacterium that act to protect the cell or organism." [GOC:jl] synonym: "antibacterial peptide activity" RELATED [] synonym: "defence response to bacteria" EXACT [] synonym: "defence response to bacterium" EXACT [] synonym: "defense response to bacteria" EXACT [] synonym: "defense response to bacterium, incompatible interaction" NARROW [] synonym: "resistance response to pathogenic bacteria" NARROW [] synonym: "resistance response to pathogenic bacterium" NARROW [] is_a: GO:0006952 ! defense response is_a: GO:0009617 ! response to bacterium intersection_of: GO:0006952 ! defense response intersection_of: RO:0004009 NCBITaxon:2 ! has primary input Bacteria property_value: RO:0002161 NCBITaxon:4895 [Term] id: GO:0042762 name: regulation of sulfur metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving sulfur, the nonmetallic element sulfur or compounds that contain sulfur." [GOC:go_curators] synonym: "regulation of sulfur metabolism" EXACT [] synonym: "regulation of sulphur metabolic process" EXACT [] synonym: "regulation of sulphur metabolism" EXACT [] is_a: GO:0019222 ! regulation of metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0006790 ! regulates sulfur compound metabolic process relationship: RO:0002211 GO:0006790 ! regulates sulfur compound metabolic process [Term] id: GO:0042886 name: amide transport namespace: biological_process def: "The directed movement of an amide, any compound containing one, two, or three acyl groups attached to a nitrogen atom, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl, ISBN:0198506732] subset: goslim_pir is_a: GO:0071705 ! nitrogen compound transport intersection_of: GO:0006810 ! transport intersection_of: RO:0004009 CHEBI:32988 ! has primary input relationship: RO:0004009 CHEBI:32988 ! has primary input [Term] id: GO:0042887 name: amide transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of an amide, any compound containing one, two, or three acyl groups attached to a nitrogen atom, from one side of a membrane to the other." [GOC:jl, ISBN:0198506732] synonym: "amine/amide/polyamine channel activity" NARROW [] is_a: GO:0022857 ! transmembrane transporter activity intersection_of: GO:0022857 ! transmembrane transporter activity intersection_of: RO:0004009 CHEBI:32988 ! has primary input relationship: BFO:0000050 GO:0042886 ! part of amide transport relationship: RO:0004009 CHEBI:32988 ! has primary input [Term] id: GO:0042923 name: neuropeptide binding namespace: molecular_function def: "Interacting selectively and non-covalently and stoichiometrically with neuropeptides, peptides with direct synaptic effects (peptide neurotransmitters) or indirect modulatory effects on the nervous system (peptide neuromodulators)." [PMID:10414961, PMID:38337033] is_a: GO:0042277 ! peptide binding [Term] id: GO:0042953 name: lipoprotein transport namespace: biological_process def: "The directed movement of any conjugated, water-soluble protein in which the nonprotein group consists of a lipid or lipids, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl, ISBN:0198506732] is_a: GO:0015031 ! protein transport is_a: GO:0044872 ! lipoprotein localization intersection_of: GO:0006810 ! transport intersection_of: RO:0004009 CHEBI:6495 ! has primary input [Term] id: GO:0042981 name: regulation of apoptotic process namespace: biological_process def: "Any process that modulates the occurrence or rate of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis] comment: This term should only be used when it is not possible to determine which phase or subtype of the apoptotic process is regulated by a gene product. Whenever detailed information is available, the more granular children terms should be used. synonym: "apoptosis regulator activity" RELATED [] synonym: "regulation of apoptosis" NARROW [] xref: Reactome:R-HSA-169911 "Regulation of Apoptosis" xref: Reactome:R-HSA-5633008 "TP53 Regulates Transcription of Cell Death Genes" is_a: GO:0043067 ! regulation of programmed cell death intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0006915 ! regulates apoptotic process relationship: RO:0002211 GO:0006915 ! regulates apoptotic process property_value: RO:0002161 NCBITaxon:4896 [Term] id: GO:0042995 name: cell projection namespace: cellular_component def: "A prolongation or process extending from a cell, e.g. a flagellum or axon." [GOC:jl, PMID:16318917] subset: goslim_agr subset: goslim_euk_cellular_processes_ribbon subset: goslim_flybase_ribbon subset: goslim_mouse subset: goslim_pir subset: goslim_prokaryote subset: goslim_prokaryote_ribbon synonym: "cell process" BROAD [] synonym: "cellular process" BROAD [] synonym: "cellular projection" EXACT [] is_a: GO:0110165 ! cellular anatomical structure relationship: BFO:0000050 CL:0000000 ! part of cell property_value: skos:prefLabel "cell projection" xsd:string [Term] id: GO:0042996 name: regulation of Golgi to plasma membrane protein transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the transport of proteins from the Golgi to the plasma membrane." [GOC:jl] is_a: GO:0051223 ! regulation of protein transport is_a: GO:0060627 ! regulation of vesicle-mediated transport is_a: GO:1903076 ! regulation of protein localization to plasma membrane intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0043001 ! regulates Golgi to plasma membrane protein transport relationship: RO:0002211 GO:0043001 ! regulates Golgi to plasma membrane protein transport [Term] id: GO:0042997 name: negative regulation of Golgi to plasma membrane protein transport namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the transport of proteins from the Golgi to the plasma membrane." [GOC:jl] synonym: "down regulation of Golgi to plasma membrane protein transport" EXACT [] synonym: "down-regulation of Golgi to plasma membrane protein transport" EXACT [] synonym: "downregulation of Golgi to plasma membrane protein transport" EXACT [] synonym: "inhibition of Golgi to plasma membrane protein transport" NARROW [] is_a: GO:0042996 ! regulation of Golgi to plasma membrane protein transport is_a: GO:0051224 ! negative regulation of protein transport is_a: GO:1903077 ! negative regulation of protein localization to plasma membrane intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0043001 ! negatively regulates Golgi to plasma membrane protein transport relationship: RO:0002212 GO:0043001 ! negatively regulates Golgi to plasma membrane protein transport [Term] id: GO:0042998 name: positive regulation of Golgi to plasma membrane protein transport namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the transport of proteins from the Golgi to the plasma membrane." [GOC:jl] synonym: "activation of Golgi to plasma membrane protein transport" NARROW [] synonym: "stimulation of Golgi to plasma membrane protein transport" NARROW [] synonym: "up regulation of Golgi to plasma membrane protein transport" EXACT [] synonym: "up-regulation of Golgi to plasma membrane protein transport" EXACT [] synonym: "upregulation of Golgi to plasma membrane protein transport" EXACT [] is_a: GO:0042996 ! regulation of Golgi to plasma membrane protein transport is_a: GO:0051222 ! positive regulation of protein transport is_a: GO:1903078 ! positive regulation of protein localization to plasma membrane intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0043001 ! positively regulates Golgi to plasma membrane protein transport relationship: RO:0002213 GO:0043001 ! positively regulates Golgi to plasma membrane protein transport [Term] id: GO:0043001 name: Golgi to plasma membrane protein transport namespace: biological_process def: "The directed movement of proteins from the Golgi to the plasma membrane in transport vesicles that move from the trans-Golgi network to the plasma membrane." [ISBN:0716731363] is_a: GO:0006893 ! Golgi to plasma membrane transport is_a: GO:0015031 ! protein transport is_a: GO:0061951 ! establishment of protein localization to plasma membrane is_a: GO:0072659 ! protein localization to plasma membrane intersection_of: GO:0015031 ! protein transport intersection_of: RO:0002338 GO:0005794 ! has target start location Golgi apparatus intersection_of: RO:0002339 GO:0005886 ! has target end location plasma membrane intersection_of: RO:0002608 GO:0031982 ! process has causal agent vesicle [Term] id: GO:0043005 name: neuron projection namespace: cellular_component def: "A prolongation or process extending from a nerve cell, e.g. an axon or dendrite." [GOC:jl, PMID:3077060] subset: goslim_pir synonym: "nerve fiber" RELATED [GOC:dph] synonym: "neurite" NARROW [] synonym: "neuron process" EXACT [] synonym: "neuron protrusion" EXACT [NIF_Subcellular:sao250931889] synonym: "neuronal cell projection" EXACT [] xref: NIF_Subcellular:sao867568886 is_a: GO:0120025 ! plasma membrane bounded cell projection intersection_of: GO:0120025 ! plasma membrane bounded cell projection intersection_of: BFO:0000050 CL:0000540 ! part of neuron relationship: BFO:0000050 CL:0000540 ! part of neuron relationship: RO:0002162 NCBITaxon:6072 ! in taxon Eumetazoa property_value: skos:prefLabel "neuron projection" xsd:string [Term] id: GO:0043009 name: chordate embryonic development namespace: biological_process def: "The process whose specific outcome is the progression of the embryo over time, from zygote formation through a stage including a notochord and neural tube until birth or egg hatching." [GOC:mtg_sensu] is_a: GO:0009792 ! embryo development ending in birth or egg hatching relationship: RO:0002162 NCBITaxon:7711 ! in taxon Chordata [Term] id: GO:0043010 name: camera-type eye development namespace: biological_process def: "The process whose specific outcome is the progression of the camera-type eye over time, from its formation to the mature structure. The camera-type eye is an organ of sight that receives light through an aperture and focuses it through a lens, projecting it on a photoreceptor field." [GOC:go_curators, GOC:mtg_sensu] is_a: GO:0001654 ! eye development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0000019 ! results in development of camera-type eye relationship: RO:0002296 UBERON:0000019 ! results in development of camera-type eye [Term] id: GO:0043011 name: myeloid dendritic cell differentiation namespace: biological_process def: "The process in which a monocyte acquires the specialized features of a dendritic cell, an immunocompetent cell of the lymphoid and hemopoietic systems and skin." [CL:0000782, GOC:jl] xref: Wikipedia:Dendritic_cell is_a: GO:0001773 ! myeloid dendritic cell activation is_a: GO:0002573 ! myeloid leukocyte differentiation is_a: GO:0097028 ! dendritic cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000782 ! results in acquisition of features of myeloid dendritic cell relationship: RO:0002315 CL:0000782 ! results in acquisition of features of myeloid dendritic cell [Term] id: GO:0043021 name: ribonucleoprotein complex binding namespace: molecular_function def: "Binding to a complex of RNA and protein." [GOC:bf, GOC:go_curators, GOC:vk] subset: goslim_pir synonym: "protein-RNA complex binding" EXACT [GOC:bf, GOC:vk] synonym: "ribonucleoprotein binding" EXACT [GOC:bf, GOC:vk] synonym: "RNP binding" EXACT [] is_a: GO:0044877 ! protein-containing complex binding intersection_of: GO:0005488 ! binding intersection_of: RO:0004009 GO:1990904 ! has primary input ribonucleoprotein complex relationship: RO:0004009 GO:1990904 ! has primary input ribonucleoprotein complex [Term] id: GO:0043022 name: ribosome binding namespace: molecular_function def: "Binding to a ribosome." [GOC:go_curators] synonym: "ribosome receptor activity" NARROW [] is_a: GO:0043021 ! ribonucleoprotein complex binding intersection_of: GO:0005488 ! binding intersection_of: RO:0004009 GO:0005840 ! has primary input ribosome relationship: RO:0004009 GO:0005840 ! has primary input ribosome [Term] id: GO:0043025 name: neuronal cell body namespace: cellular_component def: "The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites." [GOC:go_curators] comment: Note that 'cell body' and 'cell soma' are not used in the literature for cells that lack projections, nor for some cells (e.g. yeast with mating projections) that do have projections. subset: goslim_pir synonym: "neuron cell body" EXACT [] synonym: "neuronal cell soma" EXACT [] xref: NIF_Subcellular:sao1044911821 xref: Wikipedia:Soma_(biology) is_a: GO:0044297 ! cell body intersection_of: GO:0044297 ! cell body intersection_of: BFO:0000050 CL:0000540 ! part of neuron relationship: BFO:0000050 GO:0036477 ! part of somatodendritic compartment property_value: skos:prefLabel "neuronal cell body" xsd:string [Term] id: GO:0043029 name: T cell homeostasis namespace: biological_process def: "The process of regulating the proliferation and elimination of T cells such that the total number of T cells within a whole or part of an organism is stable over time in the absence of an outside stimulus." [GOC:mgi_curators, ISBN:0781735149] comment: Note that this term represents the return of T cell levels to stable numbers following an immune response as well as the proliferation and elimination of T cells required to maintain stable numbers in the absence of an outside stimulus. synonym: "T lymphocyte homeostasis" EXACT [] synonym: "T-cell homeostasis" EXACT [] synonym: "T-lymphocyte homeostasis" EXACT [] is_a: GO:0002260 ! lymphocyte homeostasis intersection_of: GO:0048872 ! homeostasis of number of cells intersection_of: RO:0012003 CL:0000084 ! acts on population of T cell relationship: RO:0012003 CL:0000084 ! acts on population of T cell [Term] id: GO:0043030 name: regulation of macrophage activation namespace: biological_process def: "Any process that modulates the frequency or rate of macrophage activation." [GOC:jl] synonym: "regulation of macrophage polarization" EXACT [] is_a: GO:0002694 ! regulation of leukocyte activation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0042116 ! regulates macrophage activation relationship: RO:0002211 GO:0042116 ! regulates macrophage activation [Term] id: GO:0043031 name: negative regulation of macrophage activation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of macrophage activation." [GOC:jl] synonym: "down regulation of macrophage activation" EXACT [] synonym: "down-regulation of macrophage activation" EXACT [] synonym: "downregulation of macrophage activation" EXACT [] synonym: "inhibition of macrophage activation" NARROW [] synonym: "negative regulation of macrophage polarization" EXACT [] is_a: GO:0002695 ! negative regulation of leukocyte activation is_a: GO:0043030 ! regulation of macrophage activation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0042116 ! negatively regulates macrophage activation relationship: RO:0002212 GO:0042116 ! negatively regulates macrophage activation [Term] id: GO:0043032 name: positive regulation of macrophage activation namespace: biological_process def: "Any process that stimulates, induces or increases the rate of macrophage activation." [GOC:jl] synonym: "activation of macrophage activation" NARROW [] synonym: "positive regulation of macrophage polarization" EXACT [] synonym: "stimulation of macrophage activation" NARROW [] synonym: "up regulation of macrophage activation" EXACT [] synonym: "up-regulation of macrophage activation" EXACT [] synonym: "upregulation of macrophage activation" EXACT [] is_a: GO:0002696 ! positive regulation of leukocyte activation is_a: GO:0043030 ! regulation of macrophage activation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0042116 ! positively regulates macrophage activation relationship: RO:0002213 GO:0042116 ! positively regulates macrophage activation [Term] id: GO:0043038 name: amino acid activation namespace: biological_process def: "The modification of an amino acid to an active form, for incorporation into a peptide, protein or other macromolecule." [GOC:jl] is_a: GO:0006520 ! amino acid metabolic process [Term] id: GO:0043039 name: tRNA aminoacylation namespace: biological_process def: "The chemical reactions and pathways by which the various amino acids become bonded to their corresponding tRNAs. The most common route for synthesis of aminoacyl tRNA is by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA and the alpha carboxylic acid group of an amino acid, usually catalyzed by the cognate aminoacyl-tRNA ligase. A given aminoacyl-tRNA ligase aminoacylates all species of an isoaccepting group of tRNA molecules." [GOC:ma, GOC:mah] synonym: "amino acid activation" RELATED [] synonym: "aminoacyl-tRNA biosynthesis" EXACT [GOC:mah] synonym: "aminoacyl-tRNA biosynthetic process" EXACT [GOC:mah] synonym: "tRNA charging" EXACT [] is_a: GO:0006399 ! tRNA metabolic process is_a: GO:0043038 ! amino acid activation property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/15375" xsd:anyURI [Term] id: GO:0043043 name: peptide biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of peptides, compounds of 2 or more (but usually less than 100) amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another. This may include the translation of a precursor protein and its subsequent processing into a functional peptide." [GOC:dph, GOC:jl] synonym: "peptide anabolism" EXACT [] synonym: "peptide biosynthesis" EXACT [] synonym: "peptide formation" EXACT [] synonym: "peptide synthesis" EXACT [] xref: Reactome:R-HSA-9037628 "Rhesus blood group biosynthesis" is_a: GO:0006518 ! peptide metabolic process is_a: GO:0009058 ! biosynthetic process intersection_of: GO:0009058 ! biosynthetic process intersection_of: RO:0004008 CHEBI:60466 ! has primary output relationship: RO:0004008 CHEBI:60466 ! has primary output [Term] id: GO:0043049 name: otic placode formation namespace: biological_process def: "The initial developmental process that will lead to the formation of the vertebrate inner ear. The otic placode forms as a thickening of the head ectoderm adjacent to the developing hindbrain." [GOC:go_curators, PMID:12668634] is_a: GO:0060788 ! ectodermal placode formation intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0003069 ! results in formation of anatomical entity otic placode relationship: BFO:0000050 GO:0030916 ! part of otic vesicle formation relationship: RO:0002297 UBERON:0003069 ! results in formation of anatomical entity otic placode [Term] id: GO:0043062 name: extracellular structure organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of structures in the space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane, and also covers the host cell environment outside an intracellular parasite." [GOC:ai, GOC:dph, GOC:jl, GOC:mah] subset: goslim_pir subset: goslim_prokaryote synonym: "extracellular structure organisation" EXACT [] synonym: "extracellular structure organization and biogenesis" EXACT [GOC:dph, GOC:jl, GOC:mah] is_a: GO:0016043 ! cellular component organization intersection_of: GO:0016043 ! cellular component organization intersection_of: RO:0002592 GO:0005576 ! results in organization of extracellular region relationship: RO:0002592 GO:0005576 ! results in organization of extracellular region [Term] id: GO:0043065 name: positive regulation of apoptotic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis] comment: This term should only be used when it is not possible to determine which phase or subtype of the apoptotic process is positively regulated by a gene product. Whenever detailed information is available, the more granular children terms should be used. subset: goslim_chembl synonym: "activation of apoptosis" NARROW [] synonym: "positive regulation of apoptosis" NARROW [] synonym: "pro-apoptosis" RELATED [] synonym: "stimulation of apoptosis" NARROW [] synonym: "up regulation of apoptosis" EXACT [] synonym: "up-regulation of apoptosis" EXACT [] synonym: "upregulation of apoptosis" EXACT [] xref: Reactome:R-HSA-193648 "NRAGE signals death through JNK" xref: Reactome:R-HSA-205043 "NRIF signals cell death from the nucleus" is_a: GO:0042981 ! regulation of apoptotic process is_a: GO:0043068 ! positive regulation of programmed cell death intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0006915 ! positively regulates apoptotic process relationship: RO:0002213 GO:0006915 ! positively regulates apoptotic process property_value: RO:0002161 NCBITaxon:4896 [Term] id: GO:0043066 name: negative regulation of apoptotic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis] comment: This term should only be used when it is not possible to determine which phase or subtype of the apoptotic process is negatively regulated by a gene product. Whenever detailed information is available, the more granular children terms should be used. synonym: "anti-apoptosis" EXACT [] synonym: "apoptosis inhibitor activity" RELATED [] synonym: "down regulation of apoptosis" EXACT [] synonym: "down-regulation of apoptosis" EXACT [] synonym: "downregulation of apoptosis" EXACT [] synonym: "inhibition of apoptosis" NARROW [] synonym: "negative regulation of apoptosis" NARROW [] synonym: "pro-survival" RELATED [] xref: Reactome:R-HSA-193639 "p75NTR signals via NF-kB" xref: Reactome:R-HSA-211728 "Regulation of PAK-2p34 activity by PS-GAP/RHG10" xref: Reactome:R-HSA-211733 "Regulation of activated PAK-2p34 by proteasome mediated degradation" is_a: GO:0042981 ! regulation of apoptotic process is_a: GO:0043069 ! negative regulation of programmed cell death intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0006915 ! negatively regulates apoptotic process relationship: RO:0002212 GO:0006915 ! negatively regulates apoptotic process property_value: RO:0002161 NCBITaxon:4896 [Term] id: GO:0043067 name: regulation of programmed cell death namespace: biological_process def: "Any process that modulates the frequency, rate or extent of programmed cell death, cell death resulting from activation of endogenous cellular processes." [GOC:jl] synonym: "regulation of non-apoptotic programmed cell death" NARROW [] is_a: GO:0050794 ! regulation of cellular process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0012501 ! regulates programmed cell death relationship: RO:0002211 GO:0012501 ! regulates programmed cell death [Term] id: GO:0043068 name: positive regulation of programmed cell death namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of programmed cell death, cell death resulting from activation of endogenous cellular processes." [GOC:jl] synonym: "activation of programmed cell death" NARROW [] synonym: "positive regulation of non-apoptotic programmed cell death" NARROW [] synonym: "stimulation of programmed cell death" NARROW [] synonym: "up regulation of programmed cell death" EXACT [] synonym: "up-regulation of programmed cell death" EXACT [] synonym: "upregulation of programmed cell death" EXACT [] is_a: GO:0043067 ! regulation of programmed cell death is_a: GO:0048522 ! positive regulation of cellular process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0012501 ! positively regulates programmed cell death relationship: RO:0002213 GO:0012501 ! positively regulates programmed cell death [Term] id: GO:0043069 name: negative regulation of programmed cell death namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of programmed cell death, cell death resulting from activation of endogenous cellular processes." [GOC:jl] synonym: "down regulation of programmed cell death" EXACT [] synonym: "down-regulation of programmed cell death" EXACT [] synonym: "downregulation of programmed cell death" EXACT [] synonym: "inhibition of programmed cell death" NARROW [] synonym: "negative regulation of non-apoptotic programmed cell death" NARROW [] is_a: GO:0043067 ! regulation of programmed cell death is_a: GO:0048523 ! negative regulation of cellular process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0012501 ! negatively regulates programmed cell death relationship: RO:0002212 GO:0012501 ! negatively regulates programmed cell death [Term] id: GO:0043073 name: germ cell nucleus namespace: cellular_component def: "The nucleus of a germ cell, a reproductive cell in multicellular organisms." [CL:0000586, GOC:go_curators] synonym: "germ-cell nucleus" EXACT [] is_a: GO:0005634 ! nucleus intersection_of: GO:0005634 ! nucleus intersection_of: BFO:0000050 CL:0000586 ! part of germ cell relationship: BFO:0000050 CL:0000586 ! part of germ cell [Term] id: GO:0043083 name: synaptic cleft namespace: cellular_component def: "The narrow gap that separates the presynaptic and postsynaptic membranes, into which neurotransmitter is released." [GOC:jl, PMID:30784960] subset: goslim_synapse xref: NIF_Subcellular:sao243541954 is_a: GO:0005576 ! extracellular region relationship: RO:0002220 GO:0045202 ! adjacent to synapse [Term] id: GO:0043085 name: positive regulation of catalytic activity namespace: biological_process def: "Any process that activates or increases the activity of an enzyme." [GOC:ebc, GOC:jl, GOC:tb, GOC:vw] subset: gocheck_obsoletion_candidate subset: goslim_chembl synonym: "activation of enzyme activity" NARROW [] synonym: "activation of metalloenzyme activity" NARROW [] synonym: "positive regulation of enzyme activity" EXACT [GOC:tb] synonym: "positive regulation of metalloenzyme activity" NARROW [] synonym: "stimulation of enzyme activity" NARROW [] synonym: "stimulation of metalloenzyme activity" NARROW [] synonym: "up regulation of enzyme activity" EXACT [] synonym: "up regulation of metalloenzyme activity" NARROW [] synonym: "up-regulation of enzyme activity" EXACT [] synonym: "up-regulation of metalloenzyme activity" NARROW [] synonym: "upregulation of enzyme activity" EXACT [] synonym: "upregulation of metalloenzyme activity" NARROW [] is_a: GO:0044093 ! positive regulation of molecular function is_a: GO:0050790 ! regulation of catalytic activity intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0003824 ! positively regulates catalytic activity relationship: RO:0002213 GO:0003824 ! positively regulates catalytic activity [Term] id: GO:0043086 name: negative regulation of catalytic activity namespace: biological_process def: "Any process that stops or reduces the activity of an enzyme." [GOC:ebc, GOC:jl, GOC:tb, GOC:vw] subset: gocheck_obsoletion_candidate synonym: "down regulation of enzyme activity" EXACT [] synonym: "down regulation of metalloenzyme activity" NARROW [] synonym: "down-regulation of enzyme activity" EXACT [] synonym: "down-regulation of metalloenzyme activity" EXACT [] synonym: "downregulation of enzyme activity" EXACT [] synonym: "downregulation of metalloenzyme activity" NARROW [] synonym: "inhibition of enzyme activity" NARROW [] synonym: "inhibition of metalloenzyme activity" NARROW [] synonym: "negative regulation of enzyme activity" EXACT [GOC:tb] synonym: "negative regulation of metalloenzyme activity" NARROW [] is_a: GO:0044092 ! negative regulation of molecular function is_a: GO:0050790 ! regulation of catalytic activity intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0003824 ! negatively regulates catalytic activity relationship: RO:0002212 GO:0003824 ! negatively regulates catalytic activity [Term] id: GO:0043114 name: regulation of vascular permeability namespace: biological_process def: "Any process that modulates the extent to which blood vessels can be pervaded by fluid." [GOC:jl] is_a: GO:0003018 ! vascular process in circulatory system is_a: GO:0065008 ! regulation of biological quality relationship: BFO:0000050 GO:0008015 ! part of blood circulation property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0043116 name: negative regulation of vascular permeability namespace: biological_process def: "Any process that reduces the extent to which blood vessels can be pervaded by fluid." [GOC:jl] synonym: "down regulation of vascular permeability" EXACT [] synonym: "down-regulation of vascular permeability" EXACT [] synonym: "downregulation of vascular permeability" EXACT [] synonym: "inhibition of vascular permeability" NARROW [] is_a: GO:0043114 ! regulation of vascular permeability property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0043117 name: positive regulation of vascular permeability namespace: biological_process def: "Any process that increases the extent to which blood vessels can be pervaded by fluid." [GOC:jl] synonym: "activation of vascular permeability" NARROW [] synonym: "stimulation of vascular permeability" NARROW [] synonym: "up regulation of vascular permeability" EXACT [] synonym: "up-regulation of vascular permeability" EXACT [] synonym: "upregulation of vascular permeability" EXACT [] is_a: GO:0043114 ! regulation of vascular permeability property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0043129 name: surfactant homeostasis namespace: biological_process def: "Any process involved in the maintenance of a steady-state level of a surface-active agent that maintains the surface tension of a liquid." [PMID:23708874, PMID:9751757] synonym: "regulation of liquid surface tension" RELATED [] synonym: "regulation of surface tension of a liquid" RELATED [] synonym: "surfactant activity" RELATED [] is_a: GO:0140962 ! multicellular organismal-level chemical homeostasis property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/24222" xsd:anyURI property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0043133 name: hindgut contraction namespace: biological_process def: "A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the hindgut. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The hindgut is the posterior part of the alimentary canal, including the rectum, and the large intestine." [GOC:jl, GOC:mtg_muscle, UBERON:0001046] is_a: GO:0006939 ! smooth muscle contraction is_a: GO:0022600 ! digestive system process intersection_of: GO:0006939 ! smooth muscle contraction intersection_of: BFO:0000066 UBERON:0001046 ! occurs in hindgut relationship: BFO:0000066 UBERON:0001046 ! occurs in hindgut property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0043134 name: regulation of hindgut contraction namespace: biological_process def: "Any process that modulates the frequency, rate or extent of muscle contraction of the hindgut, the posterior part of the alimentary canal, including the rectum, and the large intestine." [GOC:jl, UBERON:0001046] is_a: GO:0006940 ! regulation of smooth muscle contraction is_a: GO:0044058 ! regulation of digestive system process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0043133 ! regulates hindgut contraction relationship: RO:0002211 GO:0043133 ! regulates hindgut contraction property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0043143 name: regulation of translation by machinery localization namespace: biological_process def: "Any process in which proteins and protein complexes involved in translation are transported to, or maintained in, a specific location." [GOC:jl] synonym: "establishment and maintenance of translational machinery localization" EXACT [] synonym: "establishment and maintenance of translational protein localization" EXACT [] synonym: "regulation of translation by machinery localisation" EXACT [GOC:mah] synonym: "translational machinery localization" EXACT [GOC:dph, GOC:tb] synonym: "translational protein localization" EXACT [] is_a: GO:0006417 ! regulation of translation is_a: GO:0008104 ! intracellular protein localization intersection_of: GO:0008104 ! intracellular protein localization intersection_of: BFO:0000050 GO:0006412 ! part of translation relationship: BFO:0000050 GO:0006412 ! part of translation [Term] id: GO:0043158 name: heterocyst development namespace: biological_process def: "The cellular developmental process by which a cell becomes a heterocyst, a cell that carries out nitrogen fixation. This process involves changes to the cell wall, expression of nitrogenase and other proteins involved in nitrogen fixation, and degradation of photosystem II, which produces oxygen. This process is known to occur in some cyanobacteria." [PMID:11121783, PMID:35744626] synonym: "heterocyst cell differentiation" RELATED [] synonym: "heterocyst differentiation" RELATED [] synonym: "heterocyst formation" EXACT [] is_a: GO:0048869 ! cellular developmental process intersection_of: GO:0048869 ! cellular developmental process intersection_of: RO:0002295 CL:0000724 ! results in developmental progression of heterocyst relationship: RO:0002295 CL:0000724 ! results in developmental progression of heterocyst [Term] id: GO:0043167 name: ion binding namespace: molecular_function def: "Binding to an ion, a charged atoms or groups of atoms." [GOC:jl] subset: gocheck_do_not_annotate subset: goslim_chembl subset: goslim_metagenomics subset: goslim_pir subset: goslim_yeast synonym: "atom binding" RELATED [] is_a: BFO:0000003 is_a: GO:0036094 ! small molecule binding intersection_of: GO:0005488 ! binding intersection_of: RO:0004009 CHEBI:24870 ! has primary input relationship: RO:0004009 CHEBI:24870 ! has primary input property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/26424" xsd:anyURI [Term] id: GO:0043168 name: anion binding namespace: molecular_function def: "Binding to an anion, a charged atom or group of atoms with a net negative charge." [GOC:jl] is_a: GO:0043167 ! ion binding intersection_of: GO:0005488 ! binding intersection_of: RO:0004009 CHEBI:22563 ! has primary input relationship: RO:0004009 CHEBI:22563 ! has primary input [Term] id: GO:0043169 name: cation binding namespace: molecular_function def: "Binding to a cation, a charged atom or group of atoms with a net positive charge." [GOC:jl] is_a: GO:0043167 ! ion binding intersection_of: GO:0005488 ! binding intersection_of: RO:0004009 CHEBI:36916 ! has primary input relationship: RO:0004009 CHEBI:36916 ! has primary input [Term] id: GO:0043170 name: macromolecule metabolic process namespace: biological_process def: "The chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:mah] subset: gocheck_do_not_annotate subset: goslim_pir synonym: "biopolymer metabolic process" EXACT [GOC:mtg_chebi_dec09] synonym: "macromolecule metabolism" EXACT [] synonym: "multicellular organismal macromolecule metabolic process" NARROW [] synonym: "organismal macromolecule metabolism" EXACT [] is_a: BFO:0000003 is_a: GO:0008152 ! metabolic process intersection_of: GO:0008152 ! metabolic process intersection_of: RO:0004007 CHEBI:33694 ! has primary input or output relationship: RO:0004007 CHEBI:33694 ! has primary input or output property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/26424" xsd:anyURI [Term] id: GO:0043171 name: peptide catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of peptides, compounds of 2 or more (but usually less than 100) amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another." [GOC:jl] synonym: "peptide breakdown" EXACT [] synonym: "peptide catabolism" EXACT [] synonym: "peptide degradation" EXACT [] is_a: GO:0006518 ! peptide metabolic process is_a: GO:0009056 ! catabolic process intersection_of: GO:0009056 ! catabolic process intersection_of: RO:0004009 CHEBI:60466 ! has primary input relationship: RO:0004009 CHEBI:60466 ! has primary input [Term] id: GO:0043176 name: amine binding namespace: molecular_function def: "Binding to an amine, a weakly basic organic compound that contains an amino or a substituted amino group." [GOC:jl] subset: goslim_pir is_a: BFO:0000003 is_a: GO:0005488 ! binding intersection_of: GO:0005488 ! binding intersection_of: RO:0004009 CHEBI:32952 ! has primary input relationship: RO:0004009 CHEBI:32952 ! has primary input [Term] id: GO:0043177 name: organic acid binding namespace: molecular_function def: "Binding to an organic acid, any acidic compound containing carbon in covalent linkage." [GOC:jl, ISBN:0198506732] is_a: BFO:0000003 is_a: GO:0036094 ! small molecule binding intersection_of: GO:0005488 ! binding intersection_of: RO:0004009 CHEBI:64709 ! has primary input relationship: RO:0004009 CHEBI:64709 ! has primary input [Term] id: GO:0043178 name: alcohol binding namespace: molecular_function def: "Binding to an alcohol, any of a class of alkyl compounds containing a hydroxyl group." [GOC:jl, ISBN:0198506732] subset: goslim_pir is_a: BFO:0000003 is_a: GO:0036094 ! small molecule binding intersection_of: GO:0005488 ! binding intersection_of: RO:0004009 CHEBI:30879 ! has primary input relationship: RO:0004009 CHEBI:30879 ! has primary input [Term] id: GO:0043184 name: vascular endothelial growth factor receptor 2 binding namespace: molecular_function def: "Binding to a vascular endothelial growth factor receptor 2." [GOC:st] synonym: "Flk-1 binding" EXACT [] synonym: "KDR binding" BROAD [] synonym: "kinase domain region binding" EXACT [] synonym: "VEGF receptor 2 binding" EXACT [] synonym: "VEGFR 2 binding" EXACT [] is_a: GO:0005172 ! vascular endothelial growth factor receptor binding intersection_of: GO:0005488 ! binding intersection_of: RO:0004009 PR:000002112 ! has primary input vascular endothelial growth factor receptor 2 relationship: RO:0004009 PR:000002112 ! has primary input vascular endothelial growth factor receptor 2 [Term] id: GO:0043195 name: terminal bouton namespace: cellular_component def: "Terminal inflated portion of the axon, containing the specialized apparatus necessary to release neurotransmitters. The axon terminus is considered to be the whole region of thickening and the terminal bouton is a specialized region of it." [GOC:dph, GOC:mc, GOC:nln, PMID:10218156, PMID:8409967] synonym: "bouton" EXACT [] synonym: "presynaptic bouton" EXACT [] synonym: "synaptic bouton" EXACT [NIF_Subcellular:sao187426937] synonym: "terminal button" EXACT [] xref: NIF_Subcellular:sao187426937 is_a: GO:0098793 ! presynapse relationship: BFO:0000050 GO:0043679 ! part of axon terminus [Term] id: GO:0043200 name: response to amino acid namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amino acid stimulus. An amino acid is a carboxylic acids containing one or more amino groups." [GOC:ef, GOC:mlg] synonym: "response to amino acid stimulus" EXACT [GOC:dos] is_a: GO:0001101 ! response to acid chemical intersection_of: GO:0050896 ! response to stimulus intersection_of: RO:0004009 CHEBI:35238 ! has primary input relationship: RO:0004009 CHEBI:35238 ! has primary input [Term] id: GO:0043207 name: response to external biotic stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an external biotic stimulus, an external stimulus caused by, or produced by living things." [GOC:go_curators] is_a: GO:0009605 ! response to external stimulus is_a: GO:0009607 ! response to biotic stimulus [Term] id: GO:0043208 name: glycosphingolipid binding namespace: molecular_function def: "Binding to glycosphingolipid, a compound with residues of sphingoid and at least one monosaccharide." [GOC:jl] is_a: GO:0046625 ! sphingolipid binding is_a: GO:0051861 ! glycolipid binding intersection_of: GO:0005488 ! binding intersection_of: RO:0004009 CHEBI:24402 ! has primary input relationship: RO:0004009 CHEBI:24402 ! has primary input [Term] id: GO:0043209 name: myelin sheath namespace: cellular_component def: "An electrically insulating fatty layer that surrounds the axons of many neurons. It is an outgrowth of glial cells: Schwann cells supply the myelin for peripheral neurons while oligodendrocytes supply it to those of the central nervous system." [GOC:cjm, GOC:jl, NIF_Subcellular:sao593830697, Wikipedia:Myelin] synonym: "astrocyte sheath" NARROW [NIF_Subcellular:nlx_subcell_20090204] synonym: "oligodendrocyte myelin sheath" NARROW [NIF_Subcellular:sao1279474730] synonym: "Schwann cell myelin sheath" NARROW [] xref: FMA:62983 xref: NIF_Subcellular:sao593830697 xref: Wikipedia:Myelin is_a: GO:0110165 ! cellular anatomical structure relationship: BFO:0000050 CL:0000125 ! part of glial cell property_value: skos:prefLabel "myelin sheath" xsd:string [Term] id: GO:0043226 name: organelle namespace: cellular_component def: "Organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, and prokaryotic structures such as anammoxosomes and pirellulosomes. Excludes the plasma membrane." [GOC:go_curators] subset: goslim_chembl subset: goslim_generic subset: goslim_pir subset: goslim_prokaryote subset: goslim_prokaryote_ribbon xref: NIF_Subcellular:sao1539965131 xref: Wikipedia:Organelle is_a: GO:0110165 ! cellular anatomical structure disjoint_from: GO:0044423 ! virion component property_value: skos:prefLabel "organelle" xsd:string [Term] id: GO:0043227 name: membrane-bounded organelle namespace: cellular_component def: "Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane." [GOC:go_curators] subset: gocheck_do_not_annotate synonym: "membrane-enclosed organelle" EXACT [] xref: NIF_Subcellular:sao414196390 is_a: GO:0043226 ! organelle intersection_of: GO:0043226 ! organelle intersection_of: BFO:0000051 GO:0016020 ! has part membrane disjoint_from: GO:0043228 ! membraneless organelle relationship: BFO:0000051 GO:0016020 ! has part membrane property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/28153" xsd:anyURI property_value: skos:prefLabel "membrane-bounded organelle" xsd:string [Term] id: GO:0043228 name: membraneless organelle namespace: cellular_component def: "Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane. Includes ribosomes, the cytoskeleton and chromosomes." [GOC:go_curators] subset: gocheck_do_not_annotate subset: goslim_mouse synonym: "biological condensate" RELATED [] synonym: "membrane-less organelle" EXACT [] synonym: "non-membrane-bounded organelle" EXACT [] synonym: "non-membrane-enclosed organelle" EXACT [] xref: NIF_Subcellular:sao1456184038 is_a: GO:0043226 ! organelle property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/21881" xsd:anyURI property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/28153" xsd:anyURI property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/29106" xsd:anyURI property_value: skos:prefLabel "membraneless organelle" xsd:string [Term] id: GO:0043229 name: intracellular organelle namespace: cellular_component def: "Organized structure of distinctive morphology and function, occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane." [GOC:go_curators] subset: gocheck_do_not_annotate subset: goslim_pir is_a: GO:0043226 ! organelle intersection_of: GO:0043226 ! organelle intersection_of: BFO:0000050 GO:0005622 ! part of intracellular anatomical structure disjoint_from: GO:0043230 ! extracellular organelle relationship: BFO:0000050 GO:0005622 ! part of intracellular anatomical structure property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/28153" xsd:anyURI property_value: skos:prefLabel "intracellular organelle" xsd:string [Term] id: GO:0043230 name: extracellular organelle namespace: cellular_component def: "Organized structure of distinctive morphology and function, occurring outside the cell. Includes, for example, extracellular membrane vesicles (EMVs) and the cellulosomes of anaerobic bacteria and fungi." [GOC:jl, PMID:9914479] subset: goslim_pir is_a: GO:0043226 ! organelle intersection_of: GO:0043226 ! organelle intersection_of: BFO:0000050 GO:0005576 ! part of extracellular region relationship: BFO:0000050 GO:0005576 ! part of extracellular region [Term] id: GO:0043231 name: intracellular membrane-bounded organelle namespace: cellular_component def: "Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane." [GOC:go_curators] subset: gocheck_do_not_annotate subset: goslim_pir synonym: "intracellular membrane-enclosed organelle" EXACT [] is_a: GO:0043227 ! membrane-bounded organelle is_a: GO:0043229 ! intracellular organelle intersection_of: GO:0043227 ! membrane-bounded organelle intersection_of: BFO:0000050 GO:0005622 ! part of intracellular anatomical structure property_value: skos:prefLabel "intracellular membrane-bounded organelle" xsd:string [Term] id: GO:0043232 name: intracellular membraneless organelle namespace: cellular_component def: "Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane and occurring within the cell. Includes ribosomes, the cytoskeleton and chromosomes." [GOC:go_curators] subset: gocheck_do_not_annotate subset: goslim_pir synonym: "intracellular non-membrane-bounded organelle" EXACT [] synonym: "intracellular non-membrane-enclosed organelle" EXACT [] is_a: GO:0043228 ! membraneless organelle is_a: GO:0043229 ! intracellular organelle intersection_of: GO:0043228 ! membraneless organelle intersection_of: BFO:0000050 GO:0005622 ! part of intracellular anatomical structure property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/29106" xsd:anyURI property_value: skos:prefLabel "intracellular membraneless organelle" xsd:string [Term] id: GO:0043233 name: organelle lumen namespace: cellular_component def: "The internal volume enclosed by the membranes of a particular organelle; includes the volume enclosed by a single organelle membrane, e.g. endoplasmic reticulum lumen, or the volume enclosed by the innermost of the two lipid bilayers of an organelle envelope, e.g. nuclear lumen." [GOC:jl, GOC:mah] subset: goslim_mouse is_a: GO:0031974 ! membrane-enclosed lumen intersection_of: GO:0031974 ! membrane-enclosed lumen intersection_of: BFO:0000050 GO:0043226 ! part of organelle relationship: BFO:0000050 GO:0043226 ! part of organelle property_value: skos:prefLabel "organelle lumen" xsd:string [Term] id: GO:0043235 name: receptor complex namespace: cellular_component def: "Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function." [GOC:go_curators] subset: goslim_pir is_a: BFO:0000004 is_a: GO:0032991 ! protein-containing complex intersection_of: GO:0032991 ! protein-containing complex intersection_of: RO:0002215 GO:0038023 ! capable of signaling receptor activity relationship: RO:0002215 GO:0038023 ! capable of signaling receptor activity [Term] id: GO:0043242 name: negative regulation of protein-containing complex disassembly namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of protein complex disassembly, the disaggregation of a protein complex into its constituent components." [GOC:jl] synonym: "down regulation of protein complex disassembly" EXACT [] synonym: "down-regulation of protein complex disassembly" EXACT [] synonym: "downregulation of protein complex disassembly" EXACT [] synonym: "inhibition of protein complex disassembly" NARROW [] synonym: "negative regulation of protein complex disassembly" RELATED [] is_a: GO:0043244 ! regulation of protein-containing complex disassembly is_a: GO:0051129 ! negative regulation of cellular component organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0032984 ! negatively regulates protein-containing complex disassembly relationship: RO:0002212 GO:0032984 ! negatively regulates protein-containing complex disassembly [Term] id: GO:0043243 name: positive regulation of protein-containing complex disassembly namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of protein complex disassembly, the disaggregation of a protein complex into its constituent components." [GOC:jl] synonym: "activation of protein complex disassembly" NARROW [] synonym: "positive regulation of protein complex disassembly" RELATED [] synonym: "stimulation of protein complex disassembly" NARROW [] synonym: "up regulation of protein complex disassembly" EXACT [] synonym: "up-regulation of protein complex disassembly" EXACT [] synonym: "upregulation of protein complex disassembly" EXACT [] is_a: GO:0043244 ! regulation of protein-containing complex disassembly is_a: GO:0051130 ! positive regulation of cellular component organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0032984 ! positively regulates protein-containing complex disassembly relationship: RO:0002213 GO:0032984 ! positively regulates protein-containing complex disassembly [Term] id: GO:0043244 name: regulation of protein-containing complex disassembly namespace: biological_process def: "Any process that modulates the frequency, rate or extent of protein complex disassembly, the disaggregation of a protein complex into its constituent components." [GOC:jl] synonym: "regulation of protein complex disassembly" RELATED [] is_a: GO:0051128 ! regulation of cellular component organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0032984 ! regulates protein-containing complex disassembly relationship: RO:0002211 GO:0032984 ! regulates protein-containing complex disassembly [Term] id: GO:0043249 name: erythrocyte maturation namespace: biological_process def: "A developmental process, independent of morphogenetic (shape) change, that is required for an erythrocyte to attain its fully functional state." [GOC:devbiol, GOC:jl] synonym: "RBC maturation" EXACT [CL:0000232] synonym: "red blood cell maturation" EXACT [CL:0000232] is_a: GO:0048469 ! cell maturation intersection_of: GO:0021700 ! developmental maturation intersection_of: RO:0002299 CL:0000232 ! results in maturation of erythrocyte relationship: BFO:0000050 GO:0048821 ! part of erythrocyte development relationship: RO:0002299 CL:0000232 ! results in maturation of erythrocyte [Term] id: GO:0043253 name: chloroplast ribosome namespace: cellular_component def: "A ribosome contained within a chloroplast." [GOC:ecd] is_a: GO:0009547 ! plastid ribosome intersection_of: GO:0005840 ! ribosome intersection_of: BFO:0000050 GO:0009507 ! part of chloroplast relationship: BFO:0000050 GO:0009570 ! part of chloroplast stroma property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:28009 property_value: RO:0002161 NCBITaxon:33208 property_value: RO:0002161 NCBITaxon:4751 property_value: RO:0002161 NCBITaxon:554915 [Term] id: GO:0043254 name: regulation of protein-containing complex assembly namespace: biological_process def: "Any process that modulates the frequency, rate or extent of protein complex assembly." [GOC:jl] synonym: "regulation of protein complex assembly" RELATED [] is_a: GO:0044087 ! regulation of cellular component biogenesis is_a: GO:0051128 ! regulation of cellular component organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0065003 ! regulates protein-containing complex assembly relationship: RO:0002211 GO:0065003 ! regulates protein-containing complex assembly [Term] id: GO:0043255 name: regulation of carbohydrate biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of carbohydrates." [GOC:jl] synonym: "regulation of carbohydrate anabolism" EXACT [] synonym: "regulation of carbohydrate biosynthesis" EXACT [] synonym: "regulation of carbohydrate formation" EXACT [] synonym: "regulation of carbohydrate synthesis" EXACT [] is_a: GO:0006109 ! regulation of carbohydrate metabolic process is_a: GO:0009889 ! regulation of biosynthetic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0016051 ! regulates carbohydrate biosynthetic process relationship: RO:0002211 GO:0016051 ! regulates carbohydrate biosynthetic process [Term] id: GO:0043264 name: extracellular membraneless organelle namespace: cellular_component def: "Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane and occurring outside the cell." [GOC:jl] synonym: "extracellular non-membrane-bounded organelle" EXACT [] synonym: "extracellular non-membrane-enclosed organelle" EXACT [] is_a: GO:0043228 ! membraneless organelle is_a: GO:0043230 ! extracellular organelle intersection_of: GO:0043228 ! membraneless organelle intersection_of: BFO:0000050 GO:0005576 ! part of extracellular region property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/29106" xsd:anyURI [Term] id: GO:0043266 name: regulation of potassium ion transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the directed movement of potassium ions (K+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl] synonym: "regulation of K+ conductance" NARROW [] synonym: "regulation of K+ transport" EXACT [] synonym: "regulation of potassium conductance" NARROW [] synonym: "regulation of potassium ion conductance" NARROW [] synonym: "regulation of potassium transport" EXACT [] is_a: GO:0010959 ! regulation of metal ion transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0006813 ! regulates potassium ion transport relationship: RO:0002211 GO:0006813 ! regulates potassium ion transport [Term] id: GO:0043267 name: negative regulation of potassium ion transport namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of potassium ions (K+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl] synonym: "down regulation of potassium ion transport" EXACT [] synonym: "down-regulation of potassium ion transport" EXACT [] synonym: "downregulation of potassium ion transport" EXACT [] synonym: "inhibition of potassium ion transport" NARROW [] synonym: "negative regulation of K+ transport" EXACT [] synonym: "negative regulation of potassium ion conductance" NARROW [] synonym: "negative regulation of potassium transport" EXACT [] synonym: "regulation of K+ conductance" NARROW [] synonym: "regulation of potassium conductance" NARROW [] synonym: "transmembrane conductance regulator activity" RELATED [] is_a: GO:0043266 ! regulation of potassium ion transport is_a: GO:0043271 ! negative regulation of monoatomic ion transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0006813 ! negatively regulates potassium ion transport relationship: RO:0002212 GO:0006813 ! negatively regulates potassium ion transport [Term] id: GO:0043268 name: positive regulation of potassium ion transport namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the directed movement of potassium ions (K+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl] synonym: "activation of potassium ion transport" NARROW [] synonym: "positive regulation of K+ conductance" NARROW [] synonym: "positive regulation of K+ transport" EXACT [] synonym: "positive regulation of potassium conductance" NARROW [] synonym: "positive regulation of potassium ion conductance" NARROW [] synonym: "positive regulation of potassium transport" EXACT [] synonym: "stimulation of potassium ion transport" NARROW [] synonym: "up regulation of potassium ion transport" EXACT [] synonym: "up-regulation of potassium ion transport" EXACT [] synonym: "upregulation of potassium ion transport" EXACT [] is_a: GO:0043266 ! regulation of potassium ion transport is_a: GO:0043270 ! positive regulation of monoatomic ion transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0006813 ! positively regulates potassium ion transport relationship: RO:0002213 GO:0006813 ! positively regulates potassium ion transport [Term] id: GO:0043269 name: regulation of monoatomic ion transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl] synonym: "regulation of ion transport" BROAD [] is_a: GO:0051049 ! regulation of transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0006811 ! regulates monoatomic ion transport relationship: RO:0002211 GO:0006811 ! regulates monoatomic ion transport [Term] id: GO:0043270 name: positive regulation of monoatomic ion transport namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl] synonym: "activation of ion transport" NARROW [] synonym: "stimulation of ion transport" NARROW [] synonym: "up regulation of ion transport" EXACT [] synonym: "up-regulation of ion transport" EXACT [] synonym: "upregulation of ion transport" EXACT [] is_a: GO:0043269 ! regulation of monoatomic ion transport is_a: GO:0051050 ! positive regulation of transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0006811 ! positively regulates monoatomic ion transport relationship: RO:0002213 GO:0006811 ! positively regulates monoatomic ion transport [Term] id: GO:0043271 name: negative regulation of monoatomic ion transport namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl] synonym: "down regulation of ion transport" EXACT [] synonym: "down-regulation of ion transport" EXACT [] synonym: "downregulation of ion transport" EXACT [] synonym: "inhibition of ion transport" NARROW [] synonym: "negative regulation of ion transport" BROAD [] is_a: GO:0043269 ! regulation of monoatomic ion transport is_a: GO:0051051 ! negative regulation of transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0006811 ! negatively regulates monoatomic ion transport relationship: RO:0002212 GO:0006811 ! negatively regulates monoatomic ion transport [Term] id: GO:0043277 name: apoptotic cell clearance namespace: biological_process def: "The recognition and removal of an apoptotic cell by a neighboring cell or by a phagocyte." [GOC:rk, PMID:14685684] comment: Note that unlike mammals or Drosophila, C. elegans (and many lower organisms) do not have professional macrophages/phagocytes, instead cell corpses are engulfed by neighboring cells. Cell types that can function as engulfing cells include hypodermal cells, gonadal sheath cells, pharyngeal muscle cells, and intestinal cells. synonym: "apoptotic cell removal" EXACT [] synonym: "efferocytosis" EXACT [PMID:17548650] synonym: "programmed cell clearance" EXACT [] is_a: GO:0006909 ! phagocytosis property_value: RO:0002161 NCBITaxon:4751 [Term] id: GO:0043282 name: chordate pharyngeal muscle development namespace: biological_process def: "The process whose specific outcome is the progression of the pharyngeal muscle over time, from its formation to the mature structure. A pharyngeal muscle is any muscle that forms part of the pharynx." [GOC:go_curators] is_a: GO:0007517 ! muscle organ development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0000933 ! results in development of chordate pharyngeal muscle relationship: BFO:0000050 GO:0160093 ! part of chordate pharynx development relationship: RO:0002296 UBERON:0000933 ! results in development of chordate pharyngeal muscle property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/18285" xsd:anyURI [Term] id: GO:0043292 name: contractile muscle fiber namespace: cellular_component def: "Fibers, composed of actin, myosin, and associated proteins, found in cells of smooth or striated muscle." [GOC:go_curators, ISBN:0815316194] synonym: "contractile fibre" EXACT [] is_a: GO:0043232 ! intracellular membraneless organelle is_a: GO:0099512 ! supramolecular fiber relationship: BFO:0000050 CL:0000187 ! part of muscle cell relationship: BFO:0000050 GO:0005737 ! part of cytoplasm property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/27281" xsd:anyURI property_value: skos:prefLabel "contractile muscle fiber" xsd:string [Term] id: GO:0043296 name: apical junction complex namespace: cellular_component def: "A functional unit located near the cell apex at the points of contact between epithelial cells, which in vertebrates is composed of the tight junction, the zonula adherens, and desmosomes and in some invertebrates, such as Drosophila, is composed of the subapical complex (SAC), the zonula adherens and the septate junction. Functions in the regulation of cell polarity, tissue integrity and intercellular adhesion and permeability." [GOC:go_curators, GOC:kmv, PMID:12525486, PMID:15196556] synonym: "apical cell junction complex" EXACT [GOC:mah] synonym: "apical junction" EXACT [] is_a: GO:0005911 ! cell-cell junction property_value: RO:0002161 NCBITaxon:4751 [Term] id: GO:0043297 name: apical junction assembly namespace: biological_process def: "The formation of an apical junction, a functional unit located near the cell apex at the points of contact between epithelial cells composed of the tight junction, the zonula adherens junction and the desmosomes, by the aggregation, arrangement and bonding together of its constituents." [GOC:go_curators, PMID:10854689, PMID:14729475, PMID:15196556] synonym: "apical junction complex assembly" EXACT [GOC:mah] is_a: GO:0007043 ! cell-cell junction assembly intersection_of: GO:0022607 ! cellular component assembly intersection_of: RO:0002588 GO:0043296 ! results in assembly of apical junction complex relationship: RO:0002588 GO:0043296 ! results in assembly of apical junction complex property_value: RO:0002161 NCBITaxon:4751 [Term] id: GO:0043299 name: leukocyte degranulation namespace: biological_process def: "The regulated exocytosis of secretory granules by a leukocyte." [GO_REF:0000022, GOC:add, ISBN:0781735149] synonym: "immune cell degranulation" EXACT [] synonym: "immune cell granule exocytosis" EXACT [] synonym: "leucocyte degranulation" EXACT [] synonym: "leukocyte granule exocytosis" EXACT [] is_a: GO:0002252 ! immune effector process is_a: GO:0045055 ! regulated exocytosis is_a: GO:0051649 ! establishment of localization in cell intersection_of: GO:0045055 ! regulated exocytosis intersection_of: BFO:0000066 CL:0000738 ! occurs in leukocyte relationship: BFO:0000066 CL:0000738 ! occurs in leukocyte relationship: RO:0002162 NCBITaxon:7742 ! in taxon Vertebrata [Term] id: GO:0043300 name: regulation of leukocyte degranulation namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of leukocyte degranulation." [GOC:add, ISBN:0781735149] synonym: "regulation of immune cell degranulation" EXACT [] synonym: "regulation of immune cell granule exocytosis" EXACT [] synonym: "regulation of leucocyte degranulation" EXACT [] synonym: "regulation of leukocyte granule exocytosis" EXACT [] is_a: GO:0002697 ! regulation of immune effector process is_a: GO:1903305 ! regulation of regulated secretory pathway intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0043299 ! regulates leukocyte degranulation relationship: RO:0002211 GO:0043299 ! regulates leukocyte degranulation [Term] id: GO:0043301 name: negative regulation of leukocyte degranulation namespace: biological_process def: "Any process that stops, prevents, or reduces the rate of leukocyte degranulation." [GOC:add, ISBN:0781735149] synonym: "down regulation of leukocyte degranulation" EXACT [] synonym: "down-regulation of leukocyte degranulation" EXACT [] synonym: "downregulation of leukocyte degranulation" EXACT [] synonym: "inhibition of leukocyte degranulation" NARROW [] synonym: "negative regulation of immune cell degranulation" EXACT [] synonym: "negative regulation of leucocyte degranulation" EXACT [] is_a: GO:0002698 ! negative regulation of immune effector process is_a: GO:0043300 ! regulation of leukocyte degranulation is_a: GO:1903306 ! negative regulation of regulated secretory pathway intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0043299 ! negatively regulates leukocyte degranulation relationship: RO:0002212 GO:0043299 ! negatively regulates leukocyte degranulation [Term] id: GO:0043302 name: positive regulation of leukocyte degranulation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of leukocyte degranulation." [GOC:add, ISBN:0781735149] synonym: "activation of leukocyte degranulation" NARROW [] synonym: "positive regulation of immune cell degranulation" EXACT [] synonym: "positive regulation of leucocyte degranulation" EXACT [] synonym: "stimulation of leukocyte degranulation" NARROW [] synonym: "up regulation of leukocyte degranulation" EXACT [] synonym: "up-regulation of leukocyte degranulation" EXACT [] synonym: "upregulation of leukocyte degranulation" EXACT [] is_a: GO:0002699 ! positive regulation of immune effector process is_a: GO:0043300 ! regulation of leukocyte degranulation is_a: GO:1903307 ! positive regulation of regulated secretory pathway intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0043299 ! positively regulates leukocyte degranulation relationship: RO:0002213 GO:0043299 ! positively regulates leukocyte degranulation [Term] id: GO:0043303 name: mast cell degranulation namespace: biological_process def: "The regulated exocytosis of secretory granules containing preformed mediators such as histamine, serotonin, and neutral proteases by a mast cell." [ISBN:0781735149] synonym: "mast cell granule exocytosis" EXACT [] is_a: GO:0032418 ! lysosome localization is_a: GO:0043299 ! leukocyte degranulation is_a: GO:0051656 ! establishment of organelle localization intersection_of: GO:0045055 ! regulated exocytosis intersection_of: RO:0004009 GO:0042629 ! has primary input mast cell granule relationship: BFO:0000050 GO:0002279 ! part of mast cell activation involved in immune response relationship: BFO:0000050 GO:0002448 ! part of mast cell mediated immunity relationship: RO:0004009 GO:0042629 ! has primary input mast cell granule property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/15943" xsd:anyURI [Term] id: GO:0043304 name: regulation of mast cell degranulation namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of mast cell degranulation." [ISBN:0781735149] synonym: "regulation of mast cell granule exocytosis" EXACT [] is_a: GO:0002886 ! regulation of myeloid leukocyte mediated immunity is_a: GO:0043300 ! regulation of leukocyte degranulation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0043303 ! regulates mast cell degranulation relationship: RO:0002211 GO:0043303 ! regulates mast cell degranulation [Term] id: GO:0043305 name: negative regulation of mast cell degranulation namespace: biological_process def: "Any process that stops, prevents, or reduces the rate of mast cell degranulation." [ISBN:0781735149] synonym: "down regulation of mast cell degranulation" EXACT [] synonym: "down-regulation of mast cell degranulation" EXACT [] synonym: "downregulation of mast cell degranulation" EXACT [] synonym: "inhibition of mast cell degranulation" NARROW [] synonym: "negative regulation of mast cell granule exocytosis" EXACT [] is_a: GO:0002887 ! negative regulation of myeloid leukocyte mediated immunity is_a: GO:0043301 ! negative regulation of leukocyte degranulation is_a: GO:0043304 ! regulation of mast cell degranulation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0043303 ! negatively regulates mast cell degranulation relationship: RO:0002212 GO:0043303 ! negatively regulates mast cell degranulation [Term] id: GO:0043306 name: positive regulation of mast cell degranulation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of mast cell degranulation." [ISBN:0781735149] synonym: "activation of mast cell degranulation" NARROW [] synonym: "positive regulation of mast cell granule exocytosis" EXACT [] synonym: "stimulation of mast cell degranulation" NARROW [] synonym: "up regulation of mast cell degranulation" EXACT [] synonym: "up-regulation of mast cell degranulation" EXACT [] synonym: "upregulation of mast cell degranulation" EXACT [] is_a: GO:0043302 ! positive regulation of leukocyte degranulation is_a: GO:0043304 ! regulation of mast cell degranulation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0043303 ! positively regulates mast cell degranulation relationship: RO:0002213 GO:0043303 ! positively regulates mast cell degranulation [Term] id: GO:0043307 name: eosinophil activation namespace: biological_process def: "The change in morphology and behavior of a eosinophil resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor." [GOC:add, ISBN:0781735149] is_a: GO:0036230 ! granulocyte activation intersection_of: GO:0001775 ! cell activation intersection_of: RO:0004009 CL:0000771 ! has primary input eosinophil relationship: RO:0004009 CL:0000771 ! has primary input eosinophil [Term] id: GO:0043308 name: eosinophil degranulation namespace: biological_process def: "The regulated exocytosis of secretory granules containing preformed mediators such as major basic protein, eosinophil peroxidase, and eosinophil cationic protein by an eosinophil." [ISBN:0781735149] synonym: "eosinophil granule exocytosis" EXACT [] is_a: GO:0043299 ! leukocyte degranulation intersection_of: GO:0045055 ! regulated exocytosis intersection_of: BFO:0000066 CL:0000771 ! occurs in eosinophil relationship: BFO:0000050 GO:0002278 ! part of eosinophil activation involved in immune response relationship: BFO:0000050 GO:0002447 ! part of eosinophil mediated immunity relationship: BFO:0000066 CL:0000771 ! occurs in eosinophil [Term] id: GO:0043309 name: regulation of eosinophil degranulation namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of eosinophil degranulation." [ISBN:0781735149] synonym: "regulation of eosinophil granule exocytosis" EXACT [] is_a: GO:0002886 ! regulation of myeloid leukocyte mediated immunity is_a: GO:0043300 ! regulation of leukocyte degranulation is_a: GO:0050776 ! regulation of immune response intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0043308 ! regulates eosinophil degranulation relationship: RO:0002211 GO:0043308 ! regulates eosinophil degranulation [Term] id: GO:0043310 name: negative regulation of eosinophil degranulation namespace: biological_process def: "Any process that stops, prevents, or reduces the rate of eosinophil degranulation." [ISBN:0781735149] synonym: "down regulation of eosinophil degranulation" EXACT [] synonym: "down-regulation of eosinophil degranulation" EXACT [] synonym: "downregulation of eosinophil degranulation" EXACT [] synonym: "inhibition of eosinophil degranulation" NARROW [] synonym: "negative regulation of eosinophil granule exocytosis" EXACT [] is_a: GO:0002887 ! negative regulation of myeloid leukocyte mediated immunity is_a: GO:0043301 ! negative regulation of leukocyte degranulation is_a: GO:0043309 ! regulation of eosinophil degranulation is_a: GO:0050777 ! negative regulation of immune response intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0043308 ! negatively regulates eosinophil degranulation relationship: RO:0002212 GO:0043308 ! negatively regulates eosinophil degranulation [Term] id: GO:0043311 name: positive regulation of eosinophil degranulation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of eosinophil degranulation." [ISBN:0781735149] synonym: "activation of eosinophil degranulation" NARROW [] synonym: "positive regulation of eosinophil granule exocytosis" EXACT [] synonym: "stimulation of eosinophil degranulation" NARROW [] synonym: "up regulation of eosinophil degranulation" EXACT [] synonym: "up-regulation of eosinophil degranulation" EXACT [] synonym: "upregulation of eosinophil degranulation" EXACT [] is_a: GO:0002888 ! positive regulation of myeloid leukocyte mediated immunity is_a: GO:0043302 ! positive regulation of leukocyte degranulation is_a: GO:0043309 ! regulation of eosinophil degranulation is_a: GO:0050778 ! positive regulation of immune response intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0043308 ! positively regulates eosinophil degranulation relationship: RO:0002213 GO:0043308 ! positively regulates eosinophil degranulation [Term] id: GO:0043312 name: neutrophil degranulation namespace: biological_process def: "The regulated exocytosis of secretory granules containing preformed mediators such as proteases, lipases, and inflammatory mediators by a neutrophil." [ISBN:0781735149] synonym: "heterophil degranulation" RELATED [] synonym: "neutrophil granule exocytosis" EXACT [] xref: Reactome:R-HSA-6798695 "Neutrophil degranulation" is_a: GO:0043299 ! leukocyte degranulation intersection_of: GO:0045055 ! regulated exocytosis intersection_of: BFO:0000066 CL:0000775 ! occurs in neutrophil relationship: BFO:0000050 GO:0002283 ! part of neutrophil activation involved in immune response relationship: BFO:0000050 GO:0002446 ! part of neutrophil mediated immunity relationship: BFO:0000066 CL:0000775 ! occurs in neutrophil [Term] id: GO:0043313 name: regulation of neutrophil degranulation namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of neutrophil degranulation." [ISBN:0781735149] synonym: "regulation of neutrophil granule exocytosis" EXACT [] is_a: GO:0002886 ! regulation of myeloid leukocyte mediated immunity is_a: GO:0043300 ! regulation of leukocyte degranulation is_a: GO:0050776 ! regulation of immune response intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0043312 ! regulates neutrophil degranulation relationship: RO:0002211 GO:0043312 ! regulates neutrophil degranulation [Term] id: GO:0043314 name: negative regulation of neutrophil degranulation namespace: biological_process def: "Any process that stops, prevents, or reduces the rate of neutrophil degranulation." [ISBN:0781735149] synonym: "down regulation of neutrophil degranulation" EXACT [] synonym: "down-regulation of neutrophil degranulation" EXACT [] synonym: "downregulation of neutrophil degranulation" EXACT [] synonym: "inhibition of neutrophil degranulation" NARROW [] synonym: "negative regulation of neutrophil granule exocytosis" EXACT [] is_a: GO:0002887 ! negative regulation of myeloid leukocyte mediated immunity is_a: GO:0043301 ! negative regulation of leukocyte degranulation is_a: GO:0043313 ! regulation of neutrophil degranulation is_a: GO:0050777 ! negative regulation of immune response intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0043312 ! negatively regulates neutrophil degranulation relationship: RO:0002212 GO:0043312 ! negatively regulates neutrophil degranulation [Term] id: GO:0043315 name: positive regulation of neutrophil degranulation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of neutrophil degranulation." [ISBN:0781735149] synonym: "activation of neutrophil degranulation" NARROW [] synonym: "positive regulation of neutrophil granule exocytosis" EXACT [] synonym: "stimulation of neutrophil degranulation" NARROW [] synonym: "up regulation of neutrophil degranulation" EXACT [] synonym: "up-regulation of neutrophil degranulation" EXACT [] synonym: "upregulation of neutrophil degranulation" EXACT [] is_a: GO:0002888 ! positive regulation of myeloid leukocyte mediated immunity is_a: GO:0043302 ! positive regulation of leukocyte degranulation is_a: GO:0043313 ! regulation of neutrophil degranulation is_a: GO:0050778 ! positive regulation of immune response intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0043312 ! positively regulates neutrophil degranulation relationship: RO:0002213 GO:0043312 ! positively regulates neutrophil degranulation [Term] id: GO:0043316 name: cytotoxic T cell degranulation namespace: biological_process def: "The regulated exocytosis of secretory granules containing preformed mediators such as perforin and granzymes by a cytotoxic T cell." [ISBN:0781735149] synonym: "cytotoxic T cell granule exocytosis" EXACT [] synonym: "cytotoxic T lymphocyte degranulation" EXACT [] synonym: "cytotoxic T lymphocyte granule exocytosis" EXACT [] synonym: "cytotoxic T-cell degranulation" EXACT [] synonym: "cytotoxic T-cell granule exocytosis" EXACT [] synonym: "cytotoxic T-lymphocyte degranulation" EXACT [] synonym: "cytotoxic T-lymphocyte granule exocytosis" EXACT [] is_a: GO:0043299 ! leukocyte degranulation intersection_of: GO:0045055 ! regulated exocytosis intersection_of: BFO:0000066 CL:0000910 ! occurs in cytotoxic T cell relationship: BFO:0000050 GO:0001913 ! part of T cell mediated cytotoxicity relationship: BFO:0000050 GO:0002286 ! part of T cell activation involved in immune response relationship: BFO:0000066 CL:0000910 ! occurs in cytotoxic T cell [Term] id: GO:0043317 name: regulation of cytotoxic T cell degranulation namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of cytotoxic T cell degranulation." [ISBN:0781735149] synonym: "regulation of cytotoxic T cell granule exocytosis" EXACT [] synonym: "regulation of cytotoxic T lymphocyte degranulation" EXACT [] synonym: "regulation of cytotoxic T lymphocyte granule exocytosis" EXACT [] synonym: "regulation of cytotoxic T-cell degranulation" EXACT [] synonym: "regulation of cytotoxic T-cell granule exocytosis" EXACT [] synonym: "regulation of cytotoxic T-lymphocyte degranulation" EXACT [] synonym: "regulation of cytotoxic T-lymphocyte granule exocytosis" EXACT [] is_a: GO:0001914 ! regulation of T cell mediated cytotoxicity is_a: GO:0043300 ! regulation of leukocyte degranulation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0043316 ! regulates cytotoxic T cell degranulation relationship: RO:0002211 GO:0043316 ! regulates cytotoxic T cell degranulation [Term] id: GO:0043318 name: negative regulation of cytotoxic T cell degranulation namespace: biological_process def: "Any process that stops, prevents, or reduces the rate of cytotoxic T cell degranulation." [ISBN:0781735149] synonym: "down regulation of cytotoxic T cell degranulation" EXACT [] synonym: "down-regulation of cytotoxic T cell degranulation" EXACT [] synonym: "downregulation of cytotoxic T cell degranulation" EXACT [] synonym: "inhibition of cytotoxic T cell degranulation" NARROW [] synonym: "negative regulation of cytotoxic T cell granule exocytosis" EXACT [] synonym: "negative regulation of cytotoxic T lymphocyte degranulation" EXACT [] synonym: "negative regulation of cytotoxic T lymphocyte granule exocytosis" EXACT [] synonym: "negative regulation of cytotoxic T-cell degranulation" EXACT [] synonym: "negative regulation of cytotoxic T-cell granule exocytosis" EXACT [] synonym: "negative regulation of cytotoxic T-lymphocyte degranulation" EXACT [] synonym: "negative regulation of cytotoxic T-lymphocyte granule exocytosis" EXACT [] is_a: GO:0001915 ! negative regulation of T cell mediated cytotoxicity is_a: GO:0043301 ! negative regulation of leukocyte degranulation is_a: GO:0043317 ! regulation of cytotoxic T cell degranulation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0043316 ! negatively regulates cytotoxic T cell degranulation relationship: RO:0002212 GO:0043316 ! negatively regulates cytotoxic T cell degranulation [Term] id: GO:0043319 name: positive regulation of cytotoxic T cell degranulation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cytotoxic T cell degranulation." [ISBN:0781735149] synonym: "activation of cytotoxic T cell degranulation" NARROW [] synonym: "positive regulation of cytotoxic T cell granule exocytosis" EXACT [] synonym: "positive regulation of cytotoxic T lymphocyte degranulation" EXACT [] synonym: "positive regulation of cytotoxic T lymphocyte granule exocytosis" EXACT [] synonym: "positive regulation of cytotoxic T-cell degranulation" EXACT [] synonym: "positive regulation of cytotoxic T-cell granule exocytosis" EXACT [] synonym: "positive regulation of cytotoxic T-lymphocyte degranulation" EXACT [] synonym: "positive regulation of cytotoxic T-lymphocyte granule exocytosis" EXACT [] synonym: "stimulation of cytotoxic T cell degranulation" NARROW [] synonym: "up regulation of cytotoxic T cell degranulation" EXACT [] synonym: "up-regulation of cytotoxic T cell degranulation" EXACT [] synonym: "upregulation of cytotoxic T cell degranulation" EXACT [] is_a: GO:0001916 ! positive regulation of T cell mediated cytotoxicity is_a: GO:0043302 ! positive regulation of leukocyte degranulation is_a: GO:0043317 ! regulation of cytotoxic T cell degranulation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0043316 ! positively regulates cytotoxic T cell degranulation relationship: RO:0002213 GO:0043316 ! positively regulates cytotoxic T cell degranulation [Term] id: GO:0043320 name: natural killer cell degranulation namespace: biological_process def: "The regulated exocytosis of secretory granules containing preformed mediators such as perforin and granzymes by a natural killer cell." [ISBN:0781735149] synonym: "natural killer cell granule exocytosis" EXACT [] synonym: "NK cell degranulation" EXACT [] synonym: "NK cell granule exocytosis" EXACT [] is_a: GO:0043299 ! leukocyte degranulation intersection_of: GO:0045055 ! regulated exocytosis intersection_of: BFO:0000066 CL:0000623 ! occurs in natural killer cell relationship: BFO:0000050 GO:0002323 ! part of natural killer cell activation involved in immune response relationship: BFO:0000050 GO:0042267 ! part of natural killer cell mediated cytotoxicity relationship: BFO:0000066 CL:0000623 ! occurs in natural killer cell [Term] id: GO:0043321 name: regulation of natural killer cell degranulation namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of natural killer cell degranulation." [ISBN:0781735149] synonym: "regulation of natural killer cell granule exocytosis" EXACT [] synonym: "regulation of NK cell degranulation" EXACT [] synonym: "regulation of NK cell granule exocytosis" EXACT [] is_a: GO:0042269 ! regulation of natural killer cell mediated cytotoxicity is_a: GO:0043300 ! regulation of leukocyte degranulation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0043320 ! regulates natural killer cell degranulation relationship: RO:0002211 GO:0043320 ! regulates natural killer cell degranulation [Term] id: GO:0043322 name: negative regulation of natural killer cell degranulation namespace: biological_process def: "Any process that stops, prevents, or reduces the rate of natural killer cell degranulation." [ISBN:0781735149] synonym: "down regulation of natural killer cell degranulation" EXACT [] synonym: "down-regulation of natural killer cell degranulation" EXACT [] synonym: "downregulation of natural killer cell degranulation" EXACT [] synonym: "inhibition of natural killer cell degranulation" NARROW [] synonym: "negative regulation of natural killer cell granule exocytosis" EXACT [] synonym: "negative regulation of NK cell degranulation" EXACT [] synonym: "negative regulation of NK cell granule exocytosis" EXACT [] is_a: GO:0043301 ! negative regulation of leukocyte degranulation is_a: GO:0043321 ! regulation of natural killer cell degranulation is_a: GO:0045953 ! negative regulation of natural killer cell mediated cytotoxicity intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0043320 ! negatively regulates natural killer cell degranulation relationship: RO:0002212 GO:0043320 ! negatively regulates natural killer cell degranulation [Term] id: GO:0043323 name: positive regulation of natural killer cell degranulation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of natural killer cell degranulation." [ISBN:0781735149] synonym: "activation of natural killer cell degranulation" NARROW [] synonym: "positive regulation of natural killer cell granule exocytosis" EXACT [] synonym: "positive regulation of NK cell degranulation" EXACT [] synonym: "positive regulation of NK cell granule exocytosis" EXACT [] synonym: "stimulation of natural killer cell degranulation" NARROW [] synonym: "up regulation of natural killer cell degranulation" EXACT [] synonym: "up-regulation of natural killer cell degranulation" EXACT [] synonym: "upregulation of natural killer cell degranulation" EXACT [] is_a: GO:0043302 ! positive regulation of leukocyte degranulation is_a: GO:0043321 ! regulation of natural killer cell degranulation is_a: GO:0045954 ! positive regulation of natural killer cell mediated cytotoxicity intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0043320 ! positively regulates natural killer cell degranulation relationship: RO:0002213 GO:0043320 ! positively regulates natural killer cell degranulation [Term] id: GO:0043324 name: pigment metabolic process involved in developmental pigmentation namespace: biological_process def: "The chemical reactions and pathways involving biological pigments e.g. melanin, occurring as part of the development of an organ or organism." [GOC:jl, ISBN:0198506732] synonym: "pigment metabolic process during developmental pigmentation" RELATED [GOC:dph, GOC:tb] synonym: "pigment metabolism during developmental pigmentation" RELATED [GOC:dph, GOC:tb] is_a: GO:0043474 ! pigment metabolic process involved in pigmentation intersection_of: GO:0042440 ! pigment metabolic process intersection_of: BFO:0000050 GO:0048066 ! part of developmental pigmentation relationship: BFO:0000050 GO:0048066 ! part of developmental pigmentation [Term] id: GO:0043353 name: enucleate erythrocyte differentiation namespace: biological_process def: "The process in which a myeloid precursor cell acquires specialized features of an erythrocyte without a nucleus. An example of this process is found in Mus musculus." [GOC:go_curators] synonym: "enucleate RBC differentiation" EXACT [CL:0000232] synonym: "enucleate red blood cell differentiation" EXACT [CL:0000232] is_a: GO:0030218 ! erythrocyte differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000595 ! results in acquisition of features of enucleate erythrocyte relationship: RO:0002315 CL:0000595 ! results in acquisition of features of enucleate erythrocyte [Term] id: GO:0043354 name: enucleate erythrocyte maturation namespace: biological_process def: "A developmental process, independent of morphogenetic (shape) change, that is required for an enucleate erythrocyte to attain its fully functional state. An enucleate erythrocyte is an erythrocyte without a nucleus." [GOC:go_curators] synonym: "enucleate RBC maturation" EXACT [CL:0000232] synonym: "enucleate red blood cell maturation" EXACT [CL:0000232] is_a: GO:0043249 ! erythrocyte maturation intersection_of: GO:0021700 ! developmental maturation intersection_of: RO:0002299 CL:0000595 ! results in maturation of enucleate erythrocyte relationship: BFO:0000050 GO:0048822 ! part of enucleate erythrocyte development relationship: RO:0002299 CL:0000595 ! results in maturation of enucleate erythrocyte [Term] id: GO:0043362 name: nucleate erythrocyte maturation namespace: biological_process def: "A developmental process, independent of morphogenetic (shape) change, that is required for a nucleate erythrocyte to attain its fully functional state. A nucleate erythrocyte is an erythrocyte with a nucleus." [GOC:devbiol, GOC:jl] synonym: "nucleate RBC maturation" EXACT [CL:0000232] synonym: "nucleate red blood cell maturation" EXACT [CL:0000232] is_a: GO:0043249 ! erythrocyte maturation intersection_of: GO:0021700 ! developmental maturation intersection_of: RO:0002299 CL:0000562 ! results in maturation of nucleate erythrocyte relationship: BFO:0000050 GO:0048823 ! part of nucleate erythrocyte development relationship: RO:0002299 CL:0000562 ! results in maturation of nucleate erythrocyte [Term] id: GO:0043363 name: nucleate erythrocyte differentiation namespace: biological_process def: "The process in which a myeloid precursor cell acquires specializes features of an erythrocyte with a nucleus, as found in non-mammalian vertebrates such as birds." [GOC:jl] synonym: "nucleate RBC differentiation" EXACT [CL:0000232] synonym: "nucleate red blood cell differentiation" EXACT [CL:0000232] is_a: GO:0030218 ! erythrocyte differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000562 ! results in acquisition of features of nucleate erythrocyte relationship: RO:0002315 CL:0000562 ! results in acquisition of features of nucleate erythrocyte [Term] id: GO:0043367 name: CD4-positive, alpha-beta T cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized T cell acquires specialized features of a mature CD4-positive, alpha-beta T cell." [CL:0000624, ISBN:0781735149] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "CD4-positive, alpha beta T cell development" RELATED [GOC:add] synonym: "CD4-positive, alpha beta T cell differentiation" EXACT [GOC:bf] synonym: "CD4-positive, alpha-beta T lymphocyte differentiation" EXACT [] synonym: "CD4-positive, alpha-beta T-cell differentiation" EXACT [] synonym: "CD4-positive, alpha-beta T-lymphocyte differentiation" EXACT [] is_a: GO:0035710 ! CD4-positive, alpha-beta T cell activation is_a: GO:0046632 ! alpha-beta T cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000624 ! results in acquisition of features of CD4-positive, alpha-beta T cell relationship: RO:0002315 CL:0000624 ! results in acquisition of features of CD4-positive, alpha-beta T cell [Term] id: GO:0043368 name: positive T cell selection namespace: biological_process def: "The process of sparing immature T cells which react with self-MHC protein complexes with low affinity levels from apoptotic death." [ISBN:0781735149, PMID:12414722] synonym: "positive T lymphocyte selection" EXACT [] synonym: "positive T-cell selection" EXACT [] synonym: "positive T-lymphocyte selection" EXACT [] is_a: GO:0045058 ! T cell selection [Term] id: GO:0043370 name: regulation of CD4-positive, alpha-beta T cell differentiation namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of CD4-positive, alpha-beta T cell differentiation." [GOC:add, GOC:pr, ISBN:0781735149] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "regulation of CD4-positive T lymphocyte differentiation" EXACT [] synonym: "regulation of CD4-positive T-cell differentiation" EXACT [] synonym: "regulation of CD4-positive T-lymphocyte differentiation" EXACT [] synonym: "regulation of CD4-positive, alpha beta T cell development" RELATED [GOC:add] synonym: "regulation of CD4-positive, alpha beta T cell differentiation" EXACT [GOC:bf] synonym: "regulation of CD4-positive, alpha beta T lymphocyte differentiation" EXACT [] synonym: "regulation of CD4-positive, alpha beta T-cell differentiation" EXACT [] synonym: "regulation of CD4-positive, alpha beta T-lymphocyte differentiation" EXACT [] is_a: GO:0046637 ! regulation of alpha-beta T cell differentiation is_a: GO:2000514 ! regulation of CD4-positive, alpha-beta T cell activation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0043367 ! regulates CD4-positive, alpha-beta T cell differentiation relationship: RO:0002211 GO:0043367 ! regulates CD4-positive, alpha-beta T cell differentiation [Term] id: GO:0043371 name: negative regulation of CD4-positive, alpha-beta T cell differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of CD4-positive, alpha-beta T cell differentiation." [GOC:add, GOC:pr, ISBN:0781735149] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "down regulation of CD4-positive, alpha beta T cell differentiation" EXACT [] synonym: "down-regulation of CD4-positive, alpha beta T cell differentiation" EXACT [] synonym: "downregulation of CD4-positive, alpha beta T cell differentiation" EXACT [] synonym: "inhibition of CD4-positive, alpha beta T cell differentiation" NARROW [] synonym: "negative regulation of CD4-positive T-cell differentiation" EXACT [] synonym: "negative regulation of CD4-positive T-lymphocyte differentiation" EXACT [] synonym: "negative regulation of CD4-positive, alpha beta T cell development" RELATED [GOC:add] synonym: "negative regulation of CD4-positive, alpha beta T lymphocyte differentiation" EXACT [] synonym: "negative regulation of CD4-positive, alpha beta T-cell differentiation" EXACT [] synonym: "negative regulation of CD4-positive, alpha beta T-lymphocyte differentiation" EXACT [] is_a: GO:0043370 ! regulation of CD4-positive, alpha-beta T cell differentiation is_a: GO:0046639 ! negative regulation of alpha-beta T cell differentiation is_a: GO:2000515 ! negative regulation of CD4-positive, alpha-beta T cell activation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0043367 ! negatively regulates CD4-positive, alpha-beta T cell differentiation relationship: RO:0002212 GO:0043367 ! negatively regulates CD4-positive, alpha-beta T cell differentiation [Term] id: GO:0043372 name: positive regulation of CD4-positive, alpha-beta T cell differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of CD4-positive, alpha-beta T cell differentiation." [GOC:add, GOC:pr, ISBN:0781735149] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "activation of CD4-positive, alpha beta T cell differentiation" NARROW [] synonym: "positive regulation of CD4-positive T lymphocyte differentiation" EXACT [] synonym: "positive regulation of CD4-positive T-cell differentiation" EXACT [] synonym: "positive regulation of CD4-positive T-lymphocyte differentiation" EXACT [] synonym: "positive regulation of CD4-positive, alpha beta T cell development" RELATED [GOC:add] synonym: "positive regulation of CD4-positive, alpha beta T cell differentiation" EXACT [GOC:bf] synonym: "positive regulation of CD4-positive, alpha beta T lymphocyte differentiation" EXACT [] synonym: "positive regulation of CD4-positive, alpha beta T-cell differentiation" EXACT [] synonym: "positive regulation of CD4-positive, alpha beta T-lymphocyte differentiation" EXACT [] synonym: "stimulation of CD4-positive, alpha beta T cell differentiation" NARROW [] synonym: "up regulation of CD4-positive, alpha beta T cell differentiation" EXACT [] synonym: "up-regulation of CD4-positive, alpha beta T cell differentiation" EXACT [] synonym: "upregulation of CD4-positive, alpha beta T cell differentiation" EXACT [] is_a: GO:0043370 ! regulation of CD4-positive, alpha-beta T cell differentiation is_a: GO:0046638 ! positive regulation of alpha-beta T cell differentiation is_a: GO:2000516 ! positive regulation of CD4-positive, alpha-beta T cell activation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0043367 ! positively regulates CD4-positive, alpha-beta T cell differentiation relationship: RO:0002213 GO:0043367 ! positively regulates CD4-positive, alpha-beta T cell differentiation [Term] id: GO:0043374 name: CD8-positive, alpha-beta T cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized T cell acquires specialized features of a mature CD8-positive, alpha-beta T cell." [ISBN:0781735149] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "CD8-positive, alpha-beta T cell development" RELATED [GOC:add] synonym: "CD8-positive, alpha-beta T lymphocyte differentiation" EXACT [] synonym: "CD8-positive, alpha-beta T-cell differentiation" EXACT [] synonym: "CD8-positive, alpha-beta T-lymphocyte differentiation" EXACT [] is_a: GO:0036037 ! CD8-positive, alpha-beta T cell activation is_a: GO:0046632 ! alpha-beta T cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000625 ! results in acquisition of features of CD8-positive, alpha-beta T cell relationship: RO:0002315 CL:0000625 ! results in acquisition of features of CD8-positive, alpha-beta T cell [Term] id: GO:0043376 name: regulation of CD8-positive, alpha-beta T cell differentiation namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of CD8-positive, alpha-beta T cell differentiation." [GOC:add, ISBN:0781735149] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "regulation of CD8-positive T lymphocyte differentiation" EXACT [] synonym: "regulation of CD8-positive T-cell differentiation" EXACT [] synonym: "regulation of CD8-positive T-lymphocyte differentiation" EXACT [] synonym: "regulation of CD8-positive, alpha beta T lymphocyte differentiation" EXACT [] synonym: "regulation of CD8-positive, alpha beta T-cell differentiation" EXACT [] synonym: "regulation of CD8-positive, alpha beta T-lymphocyte differentiation" EXACT [] synonym: "regulation of CD8-positive, alpha-beta T cell development" RELATED [GOC:add] is_a: GO:0046637 ! regulation of alpha-beta T cell differentiation is_a: GO:2001185 ! regulation of CD8-positive, alpha-beta T cell activation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0043374 ! regulates CD8-positive, alpha-beta T cell differentiation relationship: RO:0002211 GO:0043374 ! regulates CD8-positive, alpha-beta T cell differentiation [Term] id: GO:0043377 name: negative regulation of CD8-positive, alpha-beta T cell differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the rate of CD8-positive, alpha-beta T cell differentiation." [GOC:add, ISBN:0781735149] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "down regulation of CD8-positive, alpha-beta T cell differentiation" EXACT [] synonym: "down-regulation of CD8-positive, alpha-beta T cell differentiation" EXACT [] synonym: "downregulation of CD8-positive, alpha-beta T cell differentiation" EXACT [] synonym: "inhibition of CD8-positive, alpha-beta T cell differentiation" NARROW [] synonym: "negative regulation of CD8-positive T lymphocyte differentiation" EXACT [] synonym: "negative regulation of CD8-positive T-cell differentiation" EXACT [] synonym: "negative regulation of CD8-positive T-lymphocyte differentiation" EXACT [] synonym: "negative regulation of CD8-positive, alpha beta T lymphocyte differentiation" EXACT [] synonym: "negative regulation of CD8-positive, alpha beta T-cell differentiation" EXACT [] synonym: "negative regulation of CD8-positive, alpha beta T-lymphocyte differentiation" EXACT [] synonym: "negative regulation of CD8-positive, alpha-beta T cell development" RELATED [GOC:add] is_a: GO:0043376 ! regulation of CD8-positive, alpha-beta T cell differentiation is_a: GO:0046639 ! negative regulation of alpha-beta T cell differentiation is_a: GO:2001186 ! negative regulation of CD8-positive, alpha-beta T cell activation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0043374 ! negatively regulates CD8-positive, alpha-beta T cell differentiation relationship: RO:0002212 GO:0043374 ! negatively regulates CD8-positive, alpha-beta T cell differentiation [Term] id: GO:0043378 name: positive regulation of CD8-positive, alpha-beta T cell differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of CD8-positive, alpha-beta T cell differentiation." [GOC:add, ISBN:0781735149] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "activation of CD8-positive, alpha-beta T cell differentiation" NARROW [] synonym: "positive regulation of CD8-positive T lymphocyte differentiation" EXACT [] synonym: "positive regulation of CD8-positive T-cell differentiation" EXACT [] synonym: "positive regulation of CD8-positive T-lymphocyte differentiation" EXACT [] synonym: "positive regulation of CD8-positive, alpha beta T lymphocyte differentiation" EXACT [] synonym: "positive regulation of CD8-positive, alpha beta T-cell differentiation" EXACT [] synonym: "positive regulation of CD8-positive, alpha beta T-lymphocyte differentiation" EXACT [] synonym: "positive regulation of CD8-positive, alpha-beta T cell development" RELATED [GOC:add] synonym: "stimulation of CD8-positive, alpha-beta T cell differentiation" NARROW [] synonym: "up regulation of CD8-positive, alpha-beta T cell differentiation" EXACT [] synonym: "up-regulation of CD8-positive, alpha-beta T cell differentiation" EXACT [] synonym: "upregulation of CD8-positive, alpha-beta T cell differentiation" EXACT [] is_a: GO:0043376 ! regulation of CD8-positive, alpha-beta T cell differentiation is_a: GO:0046638 ! positive regulation of alpha-beta T cell differentiation is_a: GO:2001187 ! positive regulation of CD8-positive, alpha-beta T cell activation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0043374 ! positively regulates CD8-positive, alpha-beta T cell differentiation relationship: RO:0002213 GO:0043374 ! positively regulates CD8-positive, alpha-beta T cell differentiation [Term] id: GO:0043379 name: memory T cell differentiation namespace: biological_process def: "The process in which a newly activated T cell acquires specialized features of a memory T cell." [ISBN:0781735149] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "memory T cell development" RELATED [GOC:add] synonym: "memory T lymphocyte differentiation" EXACT [] synonym: "memory T-cell differentiation" EXACT [] synonym: "memory T-lymphocyte differentiation" EXACT [] is_a: GO:0002292 ! T cell differentiation involved in immune response is_a: GO:0090715 ! immunological memory formation process intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000813 ! results in acquisition of features of memory T cell relationship: RO:0002315 CL:0000813 ! results in acquisition of features of memory T cell [Term] id: GO:0043380 name: regulation of memory T cell differentiation namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of memory T cell differentiation." [ISBN:0781735149] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "regulation of memory T cell development" RELATED [GOC:add] synonym: "regulation of memory T lymphocyte differentiation" EXACT [] synonym: "regulation of memory T-cell differentiation" EXACT [] synonym: "regulation of memory T-lymphocyte differentiation" EXACT [] is_a: GO:0002697 ! regulation of immune effector process is_a: GO:0045580 ! regulation of T cell differentiation is_a: GO:0050776 ! regulation of immune response intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0043379 ! regulates memory T cell differentiation relationship: RO:0002211 GO:0043379 ! regulates memory T cell differentiation [Term] id: GO:0043381 name: negative regulation of memory T cell differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the rate of memory T cell differentiation." [ISBN:0781735149] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "down regulation of memory T cell differentiation" EXACT [] synonym: "down-regulation of memory T cell differentiation" EXACT [] synonym: "downregulation of memory T cell differentiation" EXACT [] synonym: "inhibition of memory T cell differentiation" NARROW [] synonym: "negative regulation of memory T cell development" RELATED [GOC:add] synonym: "negative regulation of memory T lymphocyte differentiation" EXACT [] synonym: "negative regulation of memory T-cell differentiation" EXACT [] synonym: "negative regulation of memory T-lymphocyte differentiation" EXACT [] is_a: GO:0002698 ! negative regulation of immune effector process is_a: GO:0043380 ! regulation of memory T cell differentiation is_a: GO:0045581 ! negative regulation of T cell differentiation is_a: GO:0050777 ! negative regulation of immune response intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0043379 ! negatively regulates memory T cell differentiation relationship: RO:0002212 GO:0043379 ! negatively regulates memory T cell differentiation [Term] id: GO:0043382 name: positive regulation of memory T cell differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of memory T cell differentiation." [ISBN:0781735149] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "activation of memory T cell differentiation" NARROW [] synonym: "positive regulation of memory T cell development" RELATED [GOC:add] synonym: "positive regulation of memory T lymphocyte differentiation" EXACT [] synonym: "positive regulation of memory T-cell differentiation" EXACT [] synonym: "positive regulation of memory T-lymphocyte differentiation" EXACT [] synonym: "stimulation of memory T cell differentiation" NARROW [] synonym: "up regulation of memory T cell differentiation" EXACT [] synonym: "up-regulation of memory T cell differentiation" EXACT [] synonym: "upregulation of memory T cell differentiation" EXACT [] is_a: GO:0002699 ! positive regulation of immune effector process is_a: GO:0043380 ! regulation of memory T cell differentiation is_a: GO:0045582 ! positive regulation of T cell differentiation is_a: GO:0050778 ! positive regulation of immune response intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0043379 ! positively regulates memory T cell differentiation relationship: RO:0002213 GO:0043379 ! positively regulates memory T cell differentiation [Term] id: GO:0043384 name: pre-T cell receptor complex namespace: cellular_component def: "A receptor complex found on immature T cells consisting of a T cell receptor beta chain and the pre-TCR-alpha chain, along with additional signaling components including CD3 family members and additional signaling proteins." [ISBN:0781735149, PMID:12220932] synonym: "pre-T lymphocyte receptor complex" EXACT [] synonym: "pre-T-cell receptor complex" EXACT [] synonym: "pre-T-lymphocyte receptor complex" EXACT [] synonym: "pre-TCR complex" EXACT [] is_a: GO:0098802 ! plasma membrane signaling receptor complex [Term] id: GO:0043388 name: positive regulation of DNA binding namespace: biological_process def: "Any process that increases the frequency, rate or extent of DNA binding. DNA binding is any process in which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb] subset: gocheck_do_not_annotate synonym: "activation of DNA binding" NARROW [] synonym: "stimulation of DNA binding" NARROW [] synonym: "up regulation of DNA binding" EXACT [] synonym: "up-regulation of DNA binding" EXACT [] synonym: "upregulation of DNA binding" EXACT [] is_a: GO:0051099 ! positive regulation of binding is_a: GO:0051101 ! regulation of DNA binding intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0003677 ! positively regulates DNA binding relationship: RO:0002213 GO:0003677 ! positively regulates DNA binding [Term] id: GO:0043392 name: negative regulation of DNA binding namespace: biological_process def: "Any process that stops or reduces the frequency, rate or extent of DNA binding. DNA binding is any process in which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb] subset: gocheck_do_not_annotate synonym: "down regulation of DNA binding" EXACT [] synonym: "down-regulation of DNA binding" EXACT [] synonym: "downregulation of DNA binding" EXACT [] synonym: "inhibition of DNA binding" NARROW [] is_a: GO:0051100 ! negative regulation of binding is_a: GO:0051101 ! regulation of DNA binding intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0003677 ! negatively regulates DNA binding relationship: RO:0002212 GO:0003677 ! negatively regulates DNA binding [Term] id: GO:0043393 name: regulation of protein binding namespace: biological_process def: "Any process that modulates the frequency, rate or extent of protein binding." [GOC:go_curators] subset: gocheck_do_not_annotate is_a: GO:0051098 ! regulation of binding intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0005515 ! regulates protein binding relationship: RO:0002211 GO:0005515 ! regulates protein binding [Term] id: GO:0043394 name: proteoglycan binding namespace: molecular_function def: "Binding to a proteoglycan, any glycoprotein in which the carbohydrate units are glycosaminoglycans." [ISBN:0198506732] is_a: GO:0005515 ! protein binding is_a: GO:0097367 ! carbohydrate derivative binding intersection_of: GO:0005488 ! binding intersection_of: RO:0004009 CHEBI:37396 ! has primary input relationship: RO:0004009 CHEBI:37396 ! has primary input [Term] id: GO:0043403 name: skeletal muscle tissue regeneration namespace: biological_process def: "The regrowth of skeletal muscle tissue to repair injured or damaged muscle fibers in the postnatal stage." [GOC:ef, GOC:mtg_muscle, PMID:12021255, PMID:16607119] synonym: "myofiber turnover" RELATED [] is_a: GO:0042246 ! tissue regeneration intersection_of: GO:0031099 ! regeneration intersection_of: RO:0002299 UBERON:0001134 ! results in maturation of skeletal muscle tissue relationship: RO:0002162 NCBITaxon:7742 ! in taxon Vertebrata relationship: RO:0002299 UBERON:0001134 ! results in maturation of skeletal muscle tissue [Term] id: GO:0043412 name: macromolecule modification namespace: biological_process def: "The covalent alteration of one or more monomeric units in a polypeptide, polynucleotide, polysaccharide, or other biological macromolecule, resulting in a change in its properties." [GOC:go_curators] subset: gocheck_obsoletion_candidate subset: goslim_pir is_a: GO:0043170 ! macromolecule metabolic process property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/26424" xsd:anyURI [Term] id: GO:0043415 name: positive regulation of skeletal muscle tissue regeneration namespace: biological_process def: "Any process that activates or increase the rate of skeletal muscle regeneration." [GOC:jl] synonym: "activation of skeletal muscle regeneration" NARROW [] synonym: "stimulation of skeletal muscle regeneration" NARROW [] synonym: "up regulation of skeletal muscle regeneration" EXACT [] synonym: "up-regulation of skeletal muscle regeneration" EXACT [] synonym: "upregulation of skeletal muscle regeneration" EXACT [] is_a: GO:0043416 ! regulation of skeletal muscle tissue regeneration is_a: GO:0048639 ! positive regulation of developmental growth intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0043403 ! positively regulates skeletal muscle tissue regeneration relationship: RO:0002213 GO:0043403 ! positively regulates skeletal muscle tissue regeneration [Term] id: GO:0043416 name: regulation of skeletal muscle tissue regeneration namespace: biological_process def: "Any process that modulates the frequency, rate or extent of skeletal muscle." [GOC:jl] is_a: GO:0032101 ! regulation of response to external stimulus is_a: GO:0048638 ! regulation of developmental growth is_a: GO:2000026 ! regulation of multicellular organismal development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0043403 ! regulates skeletal muscle tissue regeneration relationship: RO:0002211 GO:0043403 ! regulates skeletal muscle tissue regeneration [Term] id: GO:0043417 name: negative regulation of skeletal muscle tissue regeneration namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of skeletal muscle regeneration." [GOC:jl] synonym: "down regulation of skeletal muscle regeneration" EXACT [] synonym: "down-regulation of skeletal muscle regeneration" EXACT [] synonym: "downregulation of skeletal muscle regeneration" EXACT [] synonym: "inhibition of skeletal muscle regeneration" NARROW [] is_a: GO:0043416 ! regulation of skeletal muscle tissue regeneration is_a: GO:0048640 ! negative regulation of developmental growth is_a: GO:0061045 ! negative regulation of wound healing intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0043403 ! negatively regulates skeletal muscle tissue regeneration relationship: RO:0002212 GO:0043403 ! negatively regulates skeletal muscle tissue regeneration [Term] id: GO:0043434 name: response to peptide hormone namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptide hormone stimulus. A peptide hormone is any of a class of peptides that are secreted into the blood stream and have endocrine functions in living animals." [PMID:11027914, PMID:15134857, Wikipedia:Peptide_hormone] synonym: "response to peptide hormone stimulus" EXACT [GOC:dos] synonym: "response to polypeptide hormone stimulus" EXACT [] is_a: GO:0009725 ! response to hormone is_a: GO:1901698 ! response to nitrogen compound is_a: GO:1901700 ! response to oxygen-containing compound intersection_of: GO:0050896 ! response to stimulus intersection_of: RO:0004009 CHEBI:25905 ! has primary input relationship: RO:0004009 CHEBI:25905 ! has primary input property_value: RO:0002161 NCBITaxon:4751 [Term] id: GO:0043436 name: oxoacid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving any oxoacid; an oxoacid is a compound which contains oxygen, at least one other element, and at least one hydrogen bound to oxygen, and which produces a conjugate base by loss of positive hydrogen ion(s) (hydrons)." [Wikipedia:Oxyacid] synonym: "keto acid metabolic process" EXACT [] synonym: "keto acid metabolism" EXACT [] synonym: "ketoacid metabolic process" EXACT [] synonym: "ketoacid metabolism" EXACT [] synonym: "oxo acid metabolic process" EXACT [] synonym: "oxo acid metabolism" EXACT [] synonym: "oxoacid metabolism" EXACT [] is_a: GO:0006082 ! organic acid metabolic process intersection_of: GO:0008152 ! metabolic process intersection_of: RO:0004007 CHEBI:35406 ! has primary input or output relationship: RO:0004007 CHEBI:35406 ! has primary input or output [Term] id: GO:0043462 name: regulation of ATP-dependent activity namespace: biological_process def: "Any process that modulates the rate of an ATP-dependent activity." [GOC:jl] subset: gocheck_obsoletion_candidate synonym: "regulation of adenosinetriphosphatase activity" EXACT [] synonym: "regulation of ATPase activity" EXACT [] is_a: GO:0065009 ! regulation of molecular function intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0140657 ! regulates ATP-dependent activity relationship: RO:0002211 GO:0140657 ! regulates ATP-dependent activity property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/22371" xsd:anyURI [Term] id: GO:0043467 name: regulation of generation of precursor metabolites and energy namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of precursor metabolites, substances from which energy is derived, and the processes involved in the liberation of energy from these substances." [GOC:jl] xref: Reactome:R-HSA-163685 "Integration of energy metabolism" is_a: GO:0019222 ! regulation of metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0006091 ! regulates generation of precursor metabolites and energy relationship: RO:0002211 GO:0006091 ! regulates generation of precursor metabolites and energy [Term] id: GO:0043470 name: regulation of carbohydrate catabolic process namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of carbohydrates." [GOC:mlg] is_a: GO:0006109 ! regulation of carbohydrate metabolic process is_a: GO:0009894 ! regulation of catabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0016052 ! regulates carbohydrate catabolic process relationship: RO:0002211 GO:0016052 ! regulates carbohydrate catabolic process [Term] id: GO:0043473 name: pigmentation namespace: biological_process def: "The accumulation of pigment in an organism, tissue or cell, either by increased deposition or by increased number of cells." [GOC:jl] subset: goslim_chembl subset: goslim_pir is_a: GO:0008150 ! biological_process relationship: RO:0002162 NCBITaxon:131567 ! in taxon cellular organisms [Term] id: GO:0043474 name: pigment metabolic process involved in pigmentation namespace: biological_process def: "The chemical reactions and pathways involving a pigment, any general or particular coloring matter in living organisms, resulting in the deposition or aggregation of pigment in an organism, tissue or cell." [GOC:dph, GOC:jl, GOC:tb] synonym: "pigment metabolic process during pigmentation" RELATED [GOC:dph, GOC:tb] synonym: "pigment metabolism during pigmentation" RELATED [] is_a: GO:0042440 ! pigment metabolic process intersection_of: GO:0042440 ! pigment metabolic process intersection_of: BFO:0000050 GO:0043473 ! part of pigmentation relationship: BFO:0000050 GO:0043473 ! part of pigmentation [Term] id: GO:0043500 name: muscle adaptation namespace: biological_process def: "A process in which muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors. These adaptive events occur in both muscle fibers and associated structures (motoneurons and capillaries), and they involve alterations in regulatory mechanisms, contractile properties and metabolic capacities." [GOC:mtg_muscle, PMID:11181628, PMID:11449884, PMID:12605307] subset: goslim_pir synonym: "muscle plasticity" RELATED [] is_a: BFO:0000003 is_a: GO:0003012 ! muscle system process is_a: GO:0050896 ! response to stimulus relationship: BFO:0000066 UBERON:0002385 ! occurs in muscle tissue property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0043501 name: skeletal muscle adaptation namespace: biological_process def: "Any process in which skeletal muscles change their phenotypic profiles in response to altered functional demands and a variety of signals." [GOC:mtg_muscle, PMID:11181628, PMID:11449884, PMID:12605307] synonym: "skeletal muscle plasticity" RELATED [] is_a: GO:0014888 ! striated muscle adaptation intersection_of: GO:0043500 ! muscle adaptation intersection_of: BFO:0000066 UBERON:0001134 ! occurs in skeletal muscle tissue relationship: BFO:0000066 UBERON:0001134 ! occurs in skeletal muscle tissue property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0043502 name: regulation of muscle adaptation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of muscle adaptation." [GOC:go_curators, GOC:mtg_muscle] synonym: "regulation of muscle plasticity" RELATED [] is_a: GO:0048583 ! regulation of response to stimulus is_a: GO:0090257 ! regulation of muscle system process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0043500 ! regulates muscle adaptation relationship: RO:0002211 GO:0043500 ! regulates muscle adaptation property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0043523 name: regulation of neuron apoptotic process namespace: biological_process def: "Any process that modulates the occurrence or rate of cell death by apoptotic process in neurons." [GOC:go_curators, GOC:mtg_apoptosis] synonym: "regulation of apoptosis of neuronal cells" EXACT [] synonym: "regulation of apoptosis of neurons" EXACT [] synonym: "regulation of neuron apoptosis" NARROW [] synonym: "regulation of neuron programmed cell death" EXACT [] synonym: "regulation of neuronal cell programmed cell death" EXACT [] synonym: "regulation of programmed cell death of neuronal cells" EXACT [] synonym: "regulation of programmed cell death, neurons" EXACT [] is_a: GO:0042981 ! regulation of apoptotic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0051402 ! regulates neuron apoptotic process relationship: RO:0002211 GO:0051402 ! regulates neuron apoptotic process property_value: RO:0002161 NCBITaxon:4896 [Term] id: GO:0043524 name: negative regulation of neuron apoptotic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process in neurons." [GOC:go_curators, GOC:mtg_apoptosis] synonym: "down regulation of neuron apoptosis" EXACT [] synonym: "down-regulation of neuron apoptosis" EXACT [] synonym: "downregulation of neuron apoptosis" EXACT [] synonym: "inhibition of neuron apoptosis" NARROW [] synonym: "negative regulation of neuron apoptosis" NARROW [] synonym: "negative regulation of programmed cell death, neurons" EXACT [] synonym: "neuron survival" NARROW [] is_a: GO:0043066 ! negative regulation of apoptotic process is_a: GO:0043523 ! regulation of neuron apoptotic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0051402 ! negatively regulates neuron apoptotic process relationship: RO:0002212 GO:0051402 ! negatively regulates neuron apoptotic process property_value: RO:0002161 NCBITaxon:4896 [Term] id: GO:0043525 name: positive regulation of neuron apoptotic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cell death of neurons by apoptotic process." [GOC:go_curators, GOC:mtg_apoptosis] synonym: "activation of neuron apoptosis" NARROW [] synonym: "positive regulation of neuron apoptosis" NARROW [] synonym: "positive regulation of programmed cell death, neurons" EXACT [] synonym: "stimulation of neuron apoptosis" NARROW [] synonym: "up regulation of neuron apoptosis" EXACT [] synonym: "up-regulation of neuron apoptosis" EXACT [] synonym: "upregulation of neuron apoptosis" EXACT [] is_a: GO:0043065 ! positive regulation of apoptotic process is_a: GO:0043523 ! regulation of neuron apoptotic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0051402 ! positively regulates neuron apoptotic process relationship: RO:0002213 GO:0051402 ! positively regulates neuron apoptotic process property_value: RO:0002161 NCBITaxon:4896 [Term] id: GO:0043531 name: ADP binding namespace: molecular_function def: "Binding to ADP, adenosine 5'-diphosphate." [GOC:jl] synonym: "adenosine 5'-diphosphate binding" EXACT [] synonym: "adenosine diphosphate binding" EXACT [] is_a: GO:0032559 ! adenyl ribonucleotide binding is_a: GO:0043168 ! anion binding intersection_of: GO:0005488 ! binding intersection_of: RO:0004009 CHEBI:456216 ! has primary input relationship: RO:0004009 CHEBI:456216 ! has primary input [Term] id: GO:0043534 name: blood vessel endothelial cell migration namespace: biological_process def: "The orderly movement of an endothelial cell into the extracellular matrix in order to form new blood vessels during angiogenesis." [PMID:11166264] is_a: GO:0043542 ! endothelial cell migration intersection_of: GO:0016477 ! cell migration intersection_of: RO:0002565 CL:0000071 ! results in movement of blood vessel endothelial cell relationship: RO:0002565 CL:0000071 ! results in movement of blood vessel endothelial cell property_value: RO:0002161 NCBITaxon:4890 [Term] id: GO:0043535 name: regulation of blood vessel endothelial cell migration namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the migration of the endothelial cells of blood vessels." [GOC:go_curators] is_a: GO:0010594 ! regulation of endothelial cell migration intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0043534 ! regulates blood vessel endothelial cell migration relationship: RO:0002211 GO:0043534 ! regulates blood vessel endothelial cell migration property_value: RO:0002161 NCBITaxon:451864 [Term] id: GO:0043536 name: positive regulation of blood vessel endothelial cell migration namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the migration of the endothelial cells of blood vessels." [GOC:go_curators] synonym: "activation of blood vessel endothelial cell migration" NARROW [] synonym: "stimulation of blood vessel endothelial cell migration" NARROW [] synonym: "up regulation of blood vessel endothelial cell migration" EXACT [] synonym: "up-regulation of blood vessel endothelial cell migration" EXACT [] synonym: "upregulation of blood vessel endothelial cell migration" EXACT [] is_a: GO:0010595 ! positive regulation of endothelial cell migration is_a: GO:0043535 ! regulation of blood vessel endothelial cell migration intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0043534 ! positively regulates blood vessel endothelial cell migration relationship: RO:0002213 GO:0043534 ! positively regulates blood vessel endothelial cell migration property_value: RO:0002161 NCBITaxon:451864 [Term] id: GO:0043537 name: negative regulation of blood vessel endothelial cell migration namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the migration of the endothelial cells of blood vessels." [GOC:go_curators] synonym: "down regulation of blood vessel endothelial cell migration" EXACT [] synonym: "down-regulation of blood vessel endothelial cell migration" EXACT [] synonym: "downregulation of blood vessel endothelial cell migration" EXACT [] synonym: "inhibition of blood vessel endothelial cell migration" NARROW [] is_a: GO:0010596 ! negative regulation of endothelial cell migration is_a: GO:0043535 ! regulation of blood vessel endothelial cell migration intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0043534 ! negatively regulates blood vessel endothelial cell migration relationship: RO:0002212 GO:0043534 ! negatively regulates blood vessel endothelial cell migration property_value: RO:0002161 NCBITaxon:451864 [Term] id: GO:0043542 name: endothelial cell migration namespace: biological_process def: "The orderly movement of an endothelial cell into the extracellular matrix to form an endothelium." [GOC:go_curators] is_a: BFO:0000003 is_a: GO:0016477 ! cell migration intersection_of: GO:0016477 ! cell migration intersection_of: RO:0002565 CL:0000115 ! results in movement of endothelial cell relationship: RO:0002565 CL:0000115 ! results in movement of endothelial cell property_value: RO:0002161 NCBITaxon:4890 [Term] id: GO:0043549 name: regulation of kinase activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [GOC:bf] subset: gocheck_obsoletion_candidate is_a: GO:0042325 ! regulation of phosphorylation is_a: GO:0051338 ! regulation of transferase activity intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0016301 ! regulates kinase activity relationship: RO:0002211 GO:0016301 ! regulates kinase activity [Term] id: GO:0043555 name: regulation of translation in response to stress namespace: biological_process def: "Modulation of the frequency, rate or extent of translation as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:jl] synonym: "translational stress response" EXACT [] is_a: GO:0006417 ! regulation of translation intersection_of: GO:0065007 ! biological regulation intersection_of: BFO:0000050 GO:0033554 ! part of cellular response to stress intersection_of: RO:0002211 GO:0006412 ! regulates translation relationship: BFO:0000050 GO:0033554 ! part of cellular response to stress [Term] id: GO:0043556 name: regulation of translation in response to oxidative stress namespace: biological_process def: "Any process that modulates the frequency, rate or extent of translation as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals." [GOC:jl] is_a: GO:0032055 ! negative regulation of translation in response to stress intersection_of: GO:0065007 ! biological regulation intersection_of: BFO:0000050 GO:0034599 ! part of cellular response to oxidative stress intersection_of: RO:0002212 GO:0006412 ! negatively regulates translation relationship: BFO:0000050 GO:0034599 ! part of cellular response to oxidative stress [Term] id: GO:0043558 name: regulation of translational initiation in response to stress namespace: biological_process def: "Any process that modulates the frequency, rate or extent of translation initiation, as a result of a stimulus indicating the organism is under stress." [GOC:jl] synonym: "regulation of translation initiation in response to stress" EXACT [GOC:dph, GOC:hjd, GOC:tb] is_a: GO:0006446 ! regulation of translational initiation is_a: GO:0043555 ! regulation of translation in response to stress intersection_of: GO:0065007 ! biological regulation intersection_of: BFO:0000050 GO:0033554 ! part of cellular response to stress intersection_of: RO:0002211 GO:0006413 ! regulates translational initiation [Term] id: GO:0043559 name: insulin binding namespace: molecular_function def: "Binding to insulin, a polypeptide hormone produced by the islets of Langerhans of the pancreas in mammals, and by the homologous organs of other organisms." [ISBN:0198506732] is_a: GO:0005515 ! protein binding is_a: GO:0017046 ! peptide hormone binding intersection_of: GO:0005488 ! binding intersection_of: RO:0004009 PR:000009054 ! has primary input preproinsulin relationship: RO:0004009 PR:000009054 ! has primary input preproinsulin property_value: RO:0002161 NCBITaxon:4751 [Term] id: GO:0043572 name: plastid fission namespace: biological_process def: "The creation of two or more plastids by division of one plastid. A plastid is any member of a family of organelles found in the cytoplasm of plants and some protists, which are membrane-bounded and contain DNA." [GOC:jl] is_a: GO:0048285 ! organelle fission intersection_of: GO:0048285 ! organelle fission intersection_of: results_in_fission_of GO:0009536 ! plastid relationship: results_in_fission_of GO:0009536 ! plastid [Term] id: GO:0043576 name: regulation of respiratory gaseous exchange namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the process of gaseous exchange between an organism and its environment." [GOC:jl] is_a: GO:0051239 ! regulation of multicellular organismal process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0007585 ! regulates respiratory gaseous exchange by respiratory system relationship: RO:0002211 GO:0007585 ! regulates respiratory gaseous exchange by respiratory system property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0043583 name: ear development namespace: biological_process def: "The process whose specific outcome is the progression of the ear over time, from its formation to the mature structure. The ear is the sense organ in vertebrates that is specialized for the detection of sound, and the maintenance of balance. Includes the outer ear and middle ear, which collect and transmit sound waves; and the inner ear, which contains the organs of balance and (except in fish) hearing. Also includes the pinna, the visible part of the outer ear, present in some mammals." [GOC:jl, ISBN:0192801023] synonym: "hearing organ development" EXACT [] is_a: GO:0007423 ! sensory organ development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0001690 ! results in development of ear relationship: RO:0002162 NCBITaxon:89593 ! in taxon Craniata relationship: RO:0002296 UBERON:0001690 ! results in development of ear [Term] id: GO:0043584 name: nose development namespace: biological_process def: "The process whose specific outcome is the progression of the nose over time, from its formation to the mature structure. The nose is the specialized structure of the face that serves as the organ of the sense of smell and as part of the respiratory system. Includes the nasi externus (external nose) and cavitas nasi (nasal cavity)." [GOC:jl] synonym: "nasus development" EXACT [] is_a: GO:0007423 ! sensory organ development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0000004 ! results in development of nose relationship: BFO:0000050 GO:0060541 ! part of respiratory system development relationship: RO:0002296 UBERON:0000004 ! results in development of nose [Term] id: GO:0043585 name: nose morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the nose are generated and organized. The nose is the specialized structure of the face that serves as the organ of the sense of smell and as part of the respiratory system. Includes the nasi externus (external nose) and cavitas nasi (nasal cavity)." [GOC:jl] synonym: "nasus morphogenesis" EXACT [] is_a: GO:0090596 ! sensory organ morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0000004 ! results in morphogenesis of nose relationship: BFO:0000050 GO:0043584 ! part of nose development relationship: RO:0002298 UBERON:0000004 ! results in morphogenesis of nose [Term] id: GO:0043586 name: tongue development namespace: biological_process def: "The process whose specific outcome is the progression of the tongue over time, from its formation to the mature structure. The tongue is the movable, muscular organ on the floor of the mouth of most vertebrates, in many other mammals is the principal organ of taste, aids in the prehension of food, in swallowing, and in modifying the voice as in speech." [GOC:jl, UBERON:0001723] synonym: "glossa development" NARROW [] synonym: "lingua development" NARROW [] is_a: GO:0007423 ! sensory organ development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0001723 ! results in development of tongue relationship: RO:0002162 NCBITaxon:89593 ! in taxon Craniata relationship: RO:0002296 UBERON:0001723 ! results in development of tongue [Term] id: GO:0043587 name: tongue morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the tongue are generated and organized. The tongue is the movable, muscular organ on the floor of the mouth of most vertebrates, in man other mammals is the principal organ of taste, aids in the prehension of food, in swallowing, and in modifying the voice as in speech." [GOC:jl, UBERON:0001723] synonym: "glossa morphogenesis" NARROW [] synonym: "lingua morphogenesis" EXACT [] is_a: GO:0090596 ! sensory organ morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0001723 ! results in morphogenesis of tongue relationship: BFO:0000050 GO:0043586 ! part of tongue development relationship: RO:0002298 UBERON:0001723 ! results in morphogenesis of tongue [Term] id: GO:0043588 name: skin development namespace: biological_process def: "The process whose specific outcome is the progression of the skin over time, from its formation to the mature structure. The skin is the external membranous integument of an animal. In vertebrates the skin generally consists of two layers, an outer nonsensitive and nonvascular epidermis (cuticle or skarfskin) composed of cells which are constantly growing and multiplying in the deeper, and being thrown off in the superficial layers, as well as an inner vascular dermis (cutis, corium or true skin) composed mostly of connective tissue." [GOC:jl, UBERON:0002097] synonym: "animal skin development" EXACT [] is_a: GO:0048513 ! animal organ development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0002097 ! results in development of skin of body relationship: RO:0002296 UBERON:0002097 ! results in development of skin of body [Term] id: GO:0043589 name: skin morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the skin are generated and organized. The skin is the external membranous integument of an animal. In vertebrates the skin generally consists of two layers, an outer nonsensitive and nonvascular epidermis (cuticle or skarfskin) composed of cells which are constantly growing and multiplying in the deeper, and being thrown off in the superficial layers, as well as an inner, sensitive and vascular dermis (cutis, corium or true skin) composed mostly of connective tissue." [GOC:jl, UBERON:0002097] is_a: GO:0009887 ! animal organ morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0002097 ! results in morphogenesis of skin of body relationship: BFO:0000050 GO:0043588 ! part of skin development relationship: RO:0002298 UBERON:0002097 ! results in morphogenesis of skin of body [Term] id: GO:0043603 name: amide metabolic process namespace: biological_process def: "The chemical reactions and pathways involving an amide, any derivative of an oxoacid in which an acidic hydroxy group has been replaced by an amino or substituted amino group, as carried out by individual cells." [GOC:curators] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_annotate subset: goslim_pir synonym: "amide metabolism" EXACT [] synonym: "cellular amide metabolic process" EXACT [] is_a: BFO:0000003 is_a: GO:0008152 ! metabolic process intersection_of: GO:0008152 ! metabolic process intersection_of: RO:0004007 CHEBI:32988 ! has primary input or output relationship: RO:0004007 CHEBI:32988 ! has primary input or output property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/27189" xsd:anyURI [Term] id: GO:0043604 name: amide biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of an amide, any derivative of an oxoacid in which an acidic hydroxy group has been replaced by an amino or substituted amino group." [GOC:curators] is_a: GO:0009058 ! biosynthetic process is_a: GO:0043603 ! amide metabolic process intersection_of: GO:0009058 ! biosynthetic process intersection_of: RO:0004008 CHEBI:32988 ! has primary output relationship: RO:0004008 CHEBI:32988 ! has primary output [Term] id: GO:0043605 name: amide catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of an amide, any derivative of an oxoacid in which an acidic hydroxy group has been replaced by an amino or substituted amino group." [GOC:curators] synonym: "cellular amide catabolic process" EXACT [] is_a: GO:0009056 ! catabolic process is_a: GO:0043603 ! amide metabolic process intersection_of: GO:0009056 ! catabolic process intersection_of: RO:0004008 CHEBI:32988 ! has primary output relationship: RO:0004008 CHEBI:32988 ! has primary output [Term] id: GO:0043615 name: astrocyte cell migration namespace: biological_process def: "The orderly movement of an astrocyte, a class of large neuroglial (macroglial) cells in the central nervous system, the largest and most numerous neuroglial cells in the brain and spinal cord." [CL:0000127, GOC:go_curators] synonym: "astrocyte migration" EXACT [] synonym: "astrocytic glial cell migration" EXACT [] is_a: GO:0008347 ! glial cell migration intersection_of: GO:0016477 ! cell migration intersection_of: RO:0002565 CL:0000127 ! results in movement of astrocyte relationship: RO:0002565 CL:0000127 ! results in movement of astrocyte [Term] id: GO:0043616 name: keratinocyte proliferation namespace: biological_process def: "The multiplication or reproduction of keratinocytes, resulting in the expansion of a cell population. Keratinocytes are epidermal cells which synthesize keratin and undergo a characteristic change as they move upward from the basal layers of the epidermis to the cornified (horny) layer of the skin." [CL:0000311] is_a: GO:0050673 ! epithelial cell proliferation intersection_of: GO:0008283 ! cell population proliferation intersection_of: RO:0012003 CL:0000312 ! acts on population of keratinocyte relationship: RO:0012003 CL:0000312 ! acts on population of keratinocyte property_value: RO:0002161 NCBITaxon:4751 property_value: RO:0002161 NCBITaxon:6656 [Term] id: GO:0043648 name: dicarboxylic acid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving dicarboxylic acids, any organic acid containing two carboxyl (COOH) groups or anions (COO-)." [ISBN:0198506732] synonym: "dicarboxylate metabolic process" EXACT [] synonym: "dicarboxylate metabolism" EXACT [] synonym: "dicarboxylic acid metabolism" EXACT [] is_a: GO:0019752 ! carboxylic acid metabolic process intersection_of: GO:0008152 ! metabolic process intersection_of: RO:0004007 CHEBI:35693 ! has primary input or output relationship: RO:0004007 CHEBI:35693 ! has primary input or output [Term] id: GO:0043649 name: dicarboxylic acid catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of dicarboxylic acids, any organic acid containing two carboxyl (-COOH) groups." [ISBN:0198506732] synonym: "dicarboxylate catabolic process" EXACT [] synonym: "dicarboxylate catabolism" EXACT [] synonym: "dicarboxylic acid breakdown" EXACT [] synonym: "dicarboxylic acid catabolism" EXACT [] synonym: "dicarboxylic acid degradation" EXACT [] is_a: GO:0043648 ! dicarboxylic acid metabolic process is_a: GO:0046395 ! carboxylic acid catabolic process intersection_of: GO:0009056 ! catabolic process intersection_of: RO:0004009 CHEBI:35693 ! has primary input relationship: RO:0004009 CHEBI:35693 ! has primary input [Term] id: GO:0043650 name: dicarboxylic acid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of dicarboxylic acids, any organic acid containing two carboxyl (-COOH) groups." [ISBN:0198506732] synonym: "dicarboxylate biosynthesis" EXACT [] synonym: "dicarboxylate biosynthetic process" EXACT [] synonym: "dicarboxylic acid anabolism" EXACT [] synonym: "dicarboxylic acid biosynthesis" EXACT [] synonym: "dicarboxylic acid formation" EXACT [] synonym: "dicarboxylic acid synthesis" EXACT [] is_a: GO:0043648 ! dicarboxylic acid metabolic process is_a: GO:0046394 ! carboxylic acid biosynthetic process intersection_of: GO:0009058 ! biosynthetic process intersection_of: RO:0004008 CHEBI:35693 ! has primary output relationship: RO:0004008 CHEBI:35693 ! has primary output [Term] id: GO:0043679 name: axon terminus namespace: cellular_component def: "Terminal inflated portion of the axon, containing the specialized apparatus necessary to release neurotransmitters. The axon terminus is considered to be the whole region of thickening and the terminal button is a specialized region of it." [GOC:dph, GOC:jl] synonym: "axon terminal" EXACT [NIF_Subcellular:sao2007137787] synonym: "axon terminal specialization" RELATED [] synonym: "nerve ending" EXACT [] xref: NIF_Subcellular:nlx_subcell_20090512 is_a: GO:0044306 ! neuron projection terminus is_a: GO:0098793 ! presynapse relationship: BFO:0000050 GO:0150034 ! part of distal axon [Term] id: GO:0043695 name: detection of pheromone namespace: biological_process def: "The series of events in which a pheromone stimulus is received by a cell and converted into a molecular signal." [GOC:mah] is_a: GO:0009593 ! detection of chemical stimulus is_a: GO:0019236 ! response to pheromone [Term] id: GO:0043931 name: ossification involved in bone maturation namespace: biological_process def: "The formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone, involved in the progression of the skeleton from its formation to its mature state." [GOC:dph, GOC:mah, GOC:mtg_mpo] synonym: "ossification involved in bone modeling" NARROW [GO_REF:0000034] synonym: "ossification involved in skeletal development" EXACT [GOC:dph] is_a: GO:0001503 ! ossification intersection_of: GO:0001503 ! ossification intersection_of: BFO:0000050 GO:0070977 ! part of bone maturation relationship: BFO:0000050 GO:0070977 ! part of bone maturation [Term] id: GO:0043932 name: ossification involved in bone remodeling namespace: biological_process def: "The formation or growth of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone, involved in response to injury or other physical, physiological or environmental stress stimuli." [GO_REF:0000034, GOC:mtg_mpo] synonym: "ossification involved in bone remodelling" EXACT [] is_a: GO:0001503 ! ossification intersection_of: GO:0001503 ! ossification intersection_of: BFO:0000050 GO:0046849 ! part of bone remodeling relationship: BFO:0000050 GO:0046849 ! part of bone remodeling [Term] id: GO:0043933 name: protein-containing complex organization namespace: biological_process def: "Any process in which macromolecules aggregate, disaggregate, or are modified, resulting in the formation, disassembly, or alteration of a protein complex." [GOC:mah] synonym: "cellular macromolecular complex organization" RELATED [] synonym: "cellular macromolecular complex subunit organisation" RELATED [] synonym: "cellular macromolecular complex subunit organization" RELATED [] synonym: "macromolecular complex organization" RELATED [] synonym: "macromolecular complex subunit organisation" RELATED [] synonym: "macromolecular complex subunit organization" RELATED [] synonym: "protein complex subunit organisation" EXACT [GOC:mah] synonym: "protein complex subunit organization" EXACT [] synonym: "protein-containing complex subunit organization" RELATED [] is_a: GO:0016043 ! cellular component organization intersection_of: GO:0016043 ! cellular component organization intersection_of: RO:0002592 GO:0032991 ! results in organization of protein-containing complex relationship: RO:0002592 GO:0032991 ! results in organization of protein-containing complex property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/22580" xsd:anyURI creation_date: 2010-09-08T10:01:42Z [Term] id: GO:0043934 name: sporulation namespace: biological_process def: "The process whose specific outcome is the progression of a spore over time, from its initiation to the mature structure. A spore is a structure that can be used for dissemination, for survival of adverse conditions because of its heat and desiccation resistance, and/or for reproduction." [GOC:pamgo_curators] subset: goslim_metagenomics subset: goslim_yeast xref: Wikipedia:Spore is_a: GO:0032502 ! developmental process [Term] id: GO:0043935 name: sexual sporulation resulting in formation of a cellular spore namespace: biological_process def: "The formation of spores derived from the products of meiosis. A cellular spore is a cell form that can be used for dissemination, for survival of adverse conditions because of its heat and desiccation resistance, and/or for reproduction." [GOC:pamgo_curators] is_a: GO:0030435 ! sporulation resulting in formation of a cellular spore is_a: GO:0034293 ! sexual sporulation intersection_of: GO:0030435 ! sporulation resulting in formation of a cellular spore intersection_of: BFO:0000050 GO:0051321 ! part of meiotic cell cycle property_value: RO:0002161 NCBITaxon:33083 [Term] id: GO:0043937 name: regulation of sporulation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of sporulation, the process whose specific outcome is the progression of a spore over time, from its initiation to the mature structure." [GOC:pamgo_curators] is_a: GO:0050793 ! regulation of developmental process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0043934 ! regulates sporulation relationship: RO:0002211 GO:0043934 ! regulates sporulation [Term] id: GO:0043938 name: positive regulation of sporulation namespace: biological_process def: "Any process that activates, maintains or increases the frequency, rate or extent of sporulation, the process whose specific outcome is the progression of a spore over time, from its initiation to the mature structure." [GOC:pamgo_curators] is_a: GO:0043937 ! regulation of sporulation is_a: GO:0051094 ! positive regulation of developmental process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0043934 ! positively regulates sporulation relationship: RO:0002213 GO:0043934 ! positively regulates sporulation [Term] id: GO:0043939 name: negative regulation of sporulation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of sporulation, the process whose specific outcome is the progression of a spore over time, from its initiation to the mature structure." [GOC:pamgo_curators] is_a: GO:0043937 ! regulation of sporulation is_a: GO:0051093 ! negative regulation of developmental process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0043934 ! negatively regulates sporulation relationship: RO:0002212 GO:0043934 ! negatively regulates sporulation [Term] id: GO:0043940 name: regulation of sexual sporulation resulting in formation of a cellular spore namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the formation of cellular spores derived from the products of meiosis." [GOC:pamgo_curators] is_a: GO:0034306 ! regulation of sexual sporulation is_a: GO:0042173 ! regulation of sporulation resulting in formation of a cellular spore intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0043935 ! regulates sexual sporulation resulting in formation of a cellular spore relationship: RO:0002211 GO:0043935 ! regulates sexual sporulation resulting in formation of a cellular spore [Term] id: GO:0043941 name: positive regulation of sexual sporulation resulting in formation of a cellular spore namespace: biological_process def: "Any process that activates, maintains or increases the frequency, rate or extent of the formation of cellular spores derived from the products of meiosis." [GOC:pamgo_curators] is_a: GO:0043940 ! regulation of sexual sporulation resulting in formation of a cellular spore is_a: GO:0045881 ! positive regulation of sporulation resulting in formation of a cellular spore is_a: GO:0051446 ! positive regulation of meiotic cell cycle intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0043935 ! positively regulates sexual sporulation resulting in formation of a cellular spore relationship: RO:0002213 GO:0043935 ! positively regulates sexual sporulation resulting in formation of a cellular spore [Term] id: GO:0043942 name: negative regulation of sexual sporulation resulting in formation of a cellular spore namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the formation of cellular spores derived from the products of meiosis." [GOC:pamgo_curators] is_a: GO:0042174 ! negative regulation of sporulation resulting in formation of a cellular spore is_a: GO:0043940 ! regulation of sexual sporulation resulting in formation of a cellular spore is_a: GO:0051447 ! negative regulation of meiotic cell cycle intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0043935 ! negatively regulates sexual sporulation resulting in formation of a cellular spore relationship: RO:0002212 GO:0043935 ! negatively regulates sexual sporulation resulting in formation of a cellular spore [Term] id: GO:0044042 name: glucan metabolic process namespace: biological_process def: "The chemical reactions and pathways involving glucans, polysaccharides consisting only of glucose residues." [GOC:jl] synonym: "glucan metabolism" EXACT [] is_a: GO:0005976 ! polysaccharide metabolic process intersection_of: GO:0008152 ! metabolic process intersection_of: RO:0004007 CHEBI:37163 ! has primary input or output relationship: RO:0004007 CHEBI:37163 ! has primary input or output [Term] id: GO:0044057 name: regulation of system process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of a system process, a multicellular organismal process carried out by any of the organs or tissues in an organ system." [GOC:jl] is_a: GO:0051239 ! regulation of multicellular organismal process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0003008 ! regulates system process relationship: RO:0002211 GO:0003008 ! regulates system process property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0044058 name: regulation of digestive system process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of a digestive system process, a physical, chemical, or biochemical process carried out by living organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism." [GOC:jl] is_a: GO:0044057 ! regulation of system process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0022600 ! regulates digestive system process relationship: RO:0002211 GO:0022600 ! regulates digestive system process property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0044060 name: regulation of endocrine process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of an endocrine process, a process involving the secretion of or response to endocrine hormones. An endocrine hormone is a hormone released into the circulatory system." [GOC:jl] synonym: "regulation of endocrine system process" EXACT [] is_a: GO:0044057 ! regulation of system process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0050886 ! regulates endocrine process relationship: RO:0002211 GO:0050886 ! regulates endocrine process property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0044062 name: regulation of excretion namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of excretion, the elimination by an organism of the waste products that arise as a result of metabolic activity." [GOC:jl] is_a: GO:0044057 ! regulation of system process is_a: GO:0051046 ! regulation of secretion intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0007588 ! regulates excretion relationship: RO:0002211 GO:0007588 ! regulates excretion property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0044065 name: regulation of respiratory system process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of a respiratory system process, an organ system process carried out by any of the organs or tissues of the respiratory system." [GOC:jl] is_a: GO:0043576 ! regulation of respiratory gaseous exchange is_a: GO:0044057 ! regulation of system process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0003016 ! regulates respiratory system process relationship: RO:0002211 GO:0003016 ! regulates respiratory system process property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0044085 name: cellular component biogenesis namespace: biological_process def: "A process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a cellular component. Includes biosynthesis of constituent macromolecules, and those macromolecular modifications that are involved in synthesis or assembly of the cellular component." [GOC:jl, GOC:mah] subset: gocheck_do_not_annotate subset: goslim_pir synonym: "cellular component biogenesis at cellular level" EXACT [] is_a: GO:0071840 ! cellular component organization or biogenesis property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/27194" xsd:anyURI [Term] id: GO:0044087 name: regulation of cellular component biogenesis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cellular component biogenesis, a process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a cellular component." [GOC:jl] subset: gocheck_do_not_annotate is_a: GO:0050794 ! regulation of cellular process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0044085 ! regulates cellular component biogenesis relationship: RO:0002211 GO:0044085 ! regulates cellular component biogenesis [Term] id: GO:0044088 name: regulation of vacuole organization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a vacuole." [GOC:jl, GOC:mah] synonym: "regulation of vacuole biogenesis" RELATED [GOC:mah] synonym: "regulation of vacuole organisation" EXACT [GOC:mah] is_a: GO:0033043 ! regulation of organelle organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0007033 ! regulates vacuole organization relationship: RO:0002211 GO:0007033 ! regulates vacuole organization [Term] id: GO:0044089 name: positive regulation of cellular component biogenesis namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cellular component biogenesis, a process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a cellular component." [GOC:jl] is_a: GO:0044087 ! regulation of cellular component biogenesis is_a: GO:0048522 ! positive regulation of cellular process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0044085 ! positively regulates cellular component biogenesis relationship: RO:0002213 GO:0044085 ! positively regulates cellular component biogenesis [Term] id: GO:0044090 name: positive regulation of vacuole organization namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a vacuole." [GOC:jl, GOC:mah] synonym: "positive regulation of vacuole biogenesis" RELATED [GOC:mah] synonym: "positive regulation of vacuole organisation" EXACT [GOC:mah] is_a: GO:0010638 ! positive regulation of organelle organization is_a: GO:0044088 ! regulation of vacuole organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0007033 ! positively regulates vacuole organization relationship: RO:0002213 GO:0007033 ! positively regulates vacuole organization [Term] id: GO:0044091 name: membrane biogenesis namespace: biological_process def: "A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a membrane." [GOC:jl] is_a: BFO:0000003 is_a: GO:0044085 ! cellular component biogenesis intersection_of: GO:0044085 ! cellular component biogenesis intersection_of: RO:0004008 GO:0016020 ! has primary output membrane relationship: RO:0004008 GO:0016020 ! has primary output membrane [Term] id: GO:0044092 name: negative regulation of molecular function namespace: biological_process def: "Any process that stops or reduces the rate or extent of a molecular function, an elemental biological activity occurring at the molecular level, such as catalysis or binding." [GO:jl] subset: gocheck_do_not_annotate is_a: GO:0065009 ! regulation of molecular function intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0003674 ! negatively regulates molecular_function relationship: RO:0002212 GO:0003674 ! negatively regulates molecular_function creation_date: 2009-04-21T04:07:27Z [Term] id: GO:0044093 name: positive regulation of molecular function namespace: biological_process def: "Any process that activates or increases the rate or extent of a molecular function, an elemental biological activity occurring at the molecular level, such as catalysis or binding." [GO:jl] subset: gocheck_obsoletion_candidate is_a: GO:0065009 ! regulation of molecular function intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0003674 ! positively regulates molecular_function relationship: RO:0002213 GO:0003674 ! positively regulates molecular_function creation_date: 2009-04-21T04:11:06Z [Term] id: GO:0044207 name: translation initiation ternary complex namespace: cellular_component def: "A ribonucleoprotein complex that contains aminoacylated initiator methionine tRNA, GTP, and initiation factor 2 (either eIF2 in eukaryotes, or IF2 in prokaryotes). In prokaryotes, fMet-tRNA (initiator) is used rather than Met-tRNA (initiator)." [GOC:jl] synonym: "Met-tRNA/eIF2.GTP ternary complex" NARROW [] synonym: "translation initiation (ternary) complex" EXACT [] is_a: BFO:0000004 is_a: GO:1990904 ! ribonucleoprotein complex relationship: BFO:0000050 GO:0005737 ! part of cytoplasm creation_date: 2009-10-22T02:38:55Z [Term] id: GO:0044237 name: obsolete cellular metabolic process namespace: biological_process def: "OBSOLETE. The chemical reactions and pathways by which individual cells transform chemical substances." [GOC:go_curators] comment: The reason for obsoletion is that this term is now redundant with GO:0008152, metabolic process synonym: "cellular metabolism" EXACT [] synonym: "intermediary metabolism" RELATED [GOC:mah] xref: Reactome:R-HSA-1428517 "Aerobic respiration and respiratory electron transport" property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/29021" xsd:anyURI is_obsolete: true replaced_by: GO:0008152 [Term] id: GO:0044238 name: primary metabolic process namespace: biological_process def: "The chemical reactions and pathways involving those compounds which are formed as a part of the normal anabolic and catabolic processes. These processes take place in most, if not all, cells of the organism." [GOC:go_curators] subset: gocheck_do_not_annotate subset: goslim_euk_cellular_processes_ribbon subset: goslim_pir subset: goslim_plant_ribbon subset: goslim_prokaryote_ribbon synonym: "primary metabolism" EXACT [] xref: Wikipedia:Primary_metabolite is_a: GO:0008152 ! metabolic process property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/26424" xsd:anyURI [Term] id: GO:0044258 name: intestinal lipid catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown into fatty acids and monoglycerides of lipids in the small intestine. Lipids are broken down by lipases released by the pancreas." [GOC:jl, PMID:7018485] synonym: "intestinal lipid breakdown" EXACT [] synonym: "intestinal lipid catabolism" EXACT [] synonym: "intestinal lipid degradation" EXACT [] is_a: GO:0016042 ! lipid catabolic process intersection_of: GO:0016042 ! lipid catabolic process intersection_of: BFO:0000066 UBERON:0000160 ! occurs in intestine relationship: BFO:0000066 UBERON:0000160 ! occurs in intestine [Term] id: GO:0044272 name: sulfur compound biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of compounds that contain sulfur, such as the amino acids methionine and cysteine or the tripeptide glutathione." [GOC:jl] synonym: "sulfur biosynthesis" NARROW [] synonym: "sulfur biosynthetic process" NARROW [] synonym: "sulfur compound anabolism" EXACT [] synonym: "sulfur compound biosynthesis" EXACT [] synonym: "sulfur compound formation" EXACT [] synonym: "sulfur compound synthesis" EXACT [] is_a: GO:0006790 ! sulfur compound metabolic process is_a: GO:0009058 ! biosynthetic process intersection_of: GO:0009058 ! biosynthetic process intersection_of: RO:0004008 CHEBI:26835 ! has primary output relationship: RO:0004008 CHEBI:26835 ! has primary output [Term] id: GO:0044273 name: sulfur compound catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of compounds that contain sulfur, such as the amino acids methionine and cysteine or the tripeptide glutathione." [GOC:jl] synonym: "sulfur catabolic process" NARROW [] synonym: "sulfur catabolism" NARROW [] synonym: "sulfur compound breakdown" EXACT [] synonym: "sulfur compound catabolism" EXACT [] synonym: "sulfur compound degradation" EXACT [] is_a: GO:0006790 ! sulfur compound metabolic process is_a: GO:0009056 ! catabolic process intersection_of: GO:0009056 ! catabolic process intersection_of: RO:0004009 CHEBI:26835 ! has primary input relationship: RO:0004009 CHEBI:26835 ! has primary input [Term] id: GO:0044281 name: small molecule metabolic process namespace: biological_process def: "The chemical reactions and pathways involving small molecules, any low molecular weight, monomeric, non-encoded molecule." [GOC:curators, GOC:pde, GOC:vw] comment: Small molecules in GO include monosaccharides but exclude disaccharides and polysaccharides. subset: goslim_chembl subset: goslim_flybase_ribbon subset: goslim_metagenomics synonym: "small molecule metabolism" EXACT [] is_a: GO:0008152 ! metabolic process creation_date: 2010-01-26T12:05:20Z [Term] id: GO:0044282 name: small molecule catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of small molecules, any low molecular weight, monomeric, non-encoded molecule." [GOC:curators, GOC:vw] comment: Small molecules in GO include monosaccharides but exclude disaccharides and polysaccharides. synonym: "small molecule catabolism" EXACT [] is_a: GO:0009056 ! catabolic process is_a: GO:0044281 ! small molecule metabolic process creation_date: 2010-01-26T12:06:10Z [Term] id: GO:0044283 name: small molecule biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of small molecules, any low molecular weight, monomeric, non-encoded molecule." [GOC:curators, GOC:pde, GOC:vw] comment: Small molecules in GO include monosaccharides but exclude disaccharides and polysaccharides. subset: goslim_prokaryote subset: goslim_prokaryote_ribbon synonym: "small molecule biosynthesis" EXACT [] is_a: GO:0009058 ! biosynthetic process is_a: GO:0044281 ! small molecule metabolic process creation_date: 2010-01-26T12:06:49Z [Term] id: GO:0044292 name: dendrite terminus namespace: cellular_component def: "A structure at the distal end of a dendrite adapted to carry out a specific function, e.g. dendriole." [GOC:jl, NIF_Subcellular:sao28175134] synonym: "dendrite terminal" EXACT [] synonym: "dendrite terminal specialization" RELATED [] synonym: "terminal specialization" RELATED [NIF_Subcellular:sao28175134] synonym: "terminal specialization of a dendrite" EXACT [] xref: NIF_Subcellular:sao28175134 is_a: GO:0110165 ! cellular anatomical structure relationship: BFO:0000050 GO:0030425 ! part of dendrite property_value: skos:prefLabel "dendrite terminus" xsd:string creation_date: 2010-02-04T03:14:37Z [Term] id: GO:0044293 name: dendriole namespace: cellular_component def: "Small dendrites that makes up a brush structure found as the terminal specialization of a dendrite of a unipolar brush cell (UBC)." [GOC:jl, NIF_Subcellular:sao28175134, NIF_Subcellular:sao295057932, PMID:8300904] xref: NIF_Subcellular:sao28175134 xref: NIF_Subcellular:sao295057932 is_a: GO:0044292 ! dendrite terminus property_value: skos:prefLabel "dendriole" xsd:string creation_date: 2010-02-04T03:32:02Z [Term] id: GO:0044297 name: cell body namespace: cellular_component def: "The portion of a cell bearing surface projections such as axons, dendrites, cilia, or flagella that includes the nucleus, but excludes all cell projections." [GOC:go_curators] comment: Note that 'cell body' and 'cell soma' are not used in the literature for cells that lack projections, nor for some cells (e.g. yeast with mating projections) that do have projections. synonym: "cell soma" EXACT [] xref: FBbt:00005107 xref: FMA:67301 xref: Wikipedia:Cell_body is_a: GO:0110165 ! cellular anatomical structure relationship: BFO:0000050 CL:0000000 ! part of cell property_value: RO:0002161 NCBITaxon:4890 property_value: skos:prefLabel "cell body" xsd:string creation_date: 2010-02-05T10:37:16Z [Term] id: GO:0044306 name: neuron projection terminus namespace: cellular_component def: "The specialized, terminal region of a neuron projection such as an axon or a dendrite." [GOC:jl] synonym: "nerve terminal" RELATED [PMID:25972809, PMID:9650842] synonym: "neuron projection terminal" EXACT [] synonym: "neuron terminal specialization" EXACT [] is_a: GO:0110165 ! cellular anatomical structure relationship: BFO:0000050 GO:0043005 ! part of neuron projection creation_date: 2010-02-05T02:44:04Z [Term] id: GO:0044316 name: cone cell pedicle namespace: cellular_component def: "A specialized axon terminus which is produced by retinal cone cells. Pedicles are large, conical, flat end-feet (8-10 micrometers diameter) of the retinal cone axon that lie more or less side by side on the same plane at the outer edge of the outer plexiform layer (OPL)." [PMID:10939333] synonym: "cone pedicle" EXACT [] is_a: GO:0043679 ! axon terminus creation_date: 2010-07-14T01:30:02Z [Term] id: GO:0044342 name: type B pancreatic cell proliferation namespace: biological_process def: "The multiplication or reproduction of pancreatic B cells, resulting in the expansion of an pancreatic B cell population. Pancreatic B cell are cells of the pancreas that secrete insulin." [GOC:jl, GOC:yaf] synonym: "pancreatic B cell proliferation" EXACT [GOC:mah] synonym: "pancreatic beta cell proliferation" EXACT [] is_a: GO:0050673 ! epithelial cell proliferation intersection_of: GO:0008283 ! cell population proliferation intersection_of: RO:0012003 CL:0000169 ! acts on population of type B pancreatic cell relationship: RO:0012003 CL:0000169 ! acts on population of type B pancreatic cell property_value: RO:0002161 NCBITaxon:4751 creation_date: 2010-08-25T01:44:51Z [Term] id: GO:0044346 name: fibroblast apoptotic process namespace: biological_process def: "Any apoptotic process in a fibroblast, a connective tissue cell which secretes an extracellular matrix rich in collagen and other macromolecules." [CL:0000057, GOC:jl, GOC:mtg_apoptosis, GOC:yaf] synonym: "fibroblast apoptosis" NARROW [] is_a: GO:0006915 ! apoptotic process intersection_of: GO:0006915 ! apoptotic process intersection_of: BFO:0000066 CL:0000057 ! occurs in fibroblast relationship: BFO:0000066 CL:0000057 ! occurs in fibroblast property_value: RO:0002161 NCBITaxon:4896 creation_date: 2010-09-23T11:33:38Z [Term] id: GO:0044380 name: protein localization to cytoskeleton namespace: biological_process def: "A process in which a protein is transported to, or maintained in, a location within the cytoskeleton." [GOC:jl] synonym: "protein localisation to cytoskeleton" EXACT [GOC:mah] is_a: GO:0033365 ! protein localization to organelle intersection_of: GO:0008104 ! intracellular protein localization intersection_of: RO:0002339 GO:0005856 ! has target end location cytoskeleton relationship: RO:0002339 GO:0005856 ! has target end location cytoskeleton creation_date: 2011-12-13T11:43:24Z [Term] id: GO:0044419 name: biological process involved in interspecies interaction between organisms namespace: biological_process def: "Any process evolved to enable an interaction with an organism of a different species." [GOC:cc] subset: gocheck_do_not_annotate subset: goslim_candida subset: goslim_pir synonym: "interaction with another species" EXACT [] synonym: "interspecies interaction" EXACT [] synonym: "interspecies interaction between organisms" EXACT [] synonym: "interspecies interaction with other organisms" EXACT [] xref: Reactome:R-HSA-9824443 "Parasitic Infection Pathways" is_a: GO:0008150 ! biological_process property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/20191" xsd:anyURI property_value: RO:0002161 NCBITaxon:4895 [Term] id: GO:0044423 name: virion component namespace: cellular_component def: "Any constituent part of a virion, a complete fully infectious extracellular virus particle." [GOC:jl] subset: goslim_chembl subset: goslim_metagenomics subset: goslim_pir synonym: "complete virus particle" RELATED [] synonym: "virion" RELATED [] synonym: "virion part" EXACT [] xref: Wikipedia:Virus is_a: GO:0005575 ! cellular_component disjoint_from: GO:0110165 ! cellular anatomical structure property_value: RO:0002161 NCBITaxon:131567 [Term] id: GO:0044458 name: motile cilium assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form a motile cilium." [GO_REF:0000079, GOC:cilia, GOC:krc, GOC:TermGenie, PMID:19776033, PMID:21129373, ZFIN:dsf] synonym: "motile primary cilia assembly" RELATED [GOC:TermGenie] synonym: "motile primary cilia formation" RELATED [GOC:TermGenie] synonym: "motile primary cilium assembly" RELATED [] synonym: "motile primary cilium formation" RELATED [GOC:TermGenie] synonym: "nodal cilium assembly" RELATED [GOC:TermGenie] synonym: "nodal cilium formation" RELATED [GOC:TermGenie] is_a: GO:0060271 ! cilium assembly intersection_of: GO:0022607 ! cellular component assembly intersection_of: RO:0002588 GO:0031514 ! results in assembly of motile cilium relationship: RO:0002588 GO:0031514 ! results in assembly of motile cilium property_value: RO:0002161 NCBITaxon:3176 property_value: RO:0002161 NCBITaxon:3378 property_value: RO:0002161 NCBITaxon:3398 property_value: RO:0002161 NCBITaxon:4890 property_value: RO:0002161 NCBITaxon:5782 creation_date: 2015-02-06T17:23:23Z [Term] id: GO:0044565 name: dendritic cell proliferation namespace: biological_process def: "The expansion of a dendritic cell population by cell division. A dendritic cell is a cell of hematopoietic origin, typically resident in particular tissues, specialized in the uptake, processing, and transport of antigens to lymph nodes for the purpose of stimulating an immune response via T cell activation." [CL:0000451, PMID:18469816] is_a: GO:0032943 ! mononuclear cell proliferation intersection_of: GO:0008283 ! cell population proliferation intersection_of: RO:0012003 CL:0000451 ! acts on population of dendritic cell relationship: RO:0012003 CL:0000451 ! acts on population of dendritic cell creation_date: 2012-04-05T04:31:39Z [Term] id: GO:0044566 name: chondrocyte activation namespace: biological_process def: "A change in the morphology or behavior of a chondrocyte resulting from exposure to an activating factor such as a cellular or soluble ligand. A chondrocyte is a polymorphic cell that forms cartilage." [CL:0000138, GOC:jl] is_a: BFO:0000003 is_a: GO:0001775 ! cell activation intersection_of: GO:0001775 ! cell activation intersection_of: RO:0004009 CL:0000138 ! has primary input chondrocyte relationship: RO:0004009 CL:0000138 ! has primary input chondrocyte creation_date: 2012-04-05T04:45:38Z [Term] id: GO:0044703 name: multi-organism reproductive process namespace: biological_process def: "A biological process that directly contributes to the process of producing new individuals, involving another organism." [GOC:jl] subset: gocheck_do_not_annotate subset: goslim_drosophila is_a: GO:0022414 ! reproductive process creation_date: 2012-09-19T15:56:30Z [Term] id: GO:0044706 name: multi-multicellular organism process namespace: biological_process def: "A multicellular organism process which involves another multicellular organism of the same or different species." [GOC:jl] is_a: GO:0032501 ! multicellular organismal process property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/21459" xsd:anyURI property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 creation_date: 2012-09-19T16:06:16Z [Term] id: GO:0044743 name: protein transmembrane import into intracellular organelle namespace: biological_process def: "The directed movement of proteins into an intracellular organelle, across a membrane." [GOC:jl] is_a: GO:0033365 ! protein localization to organelle is_a: GO:0065002 ! intracellular protein transmembrane transport is_a: GO:0072594 ! establishment of protein localization to organelle intersection_of: GO:0046907 ! intracellular transport intersection_of: RO:0002338 GO:0005829 ! has target start location cytosol intersection_of: RO:0002339 GO:0043229 ! has target end location intracellular organelle intersection_of: RO:0002342 GO:0031090 ! results in transport across organelle membrane intersection_of: RO:0004009 PR:000000001 ! has primary input protein relationship: RO:0002338 GO:0005829 ! has target start location cytosol relationship: RO:0002339 GO:0043229 ! has target end location intracellular organelle relationship: RO:0002342 GO:0031090 ! results in transport across organelle membrane property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/29962" xsd:anyURI creation_date: 2012-11-07T15:37:36Z [Term] id: GO:0044782 name: cilium organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole." [GOC:cilia, GOC:jl] comment: Note that we deem cilium and microtubule-based flagellum to be equivalent. subset: goslim_drosophila subset: goslim_generic synonym: "microtubule-based flagellum organization" EXACT [] is_a: GO:0006996 ! organelle organization is_a: GO:0120036 ! plasma membrane bounded cell projection organization intersection_of: GO:0016043 ! cellular component organization intersection_of: RO:0002592 GO:0005929 ! results in organization of cilium relationship: RO:0002162 NCBITaxon:2759 ! in taxon Eukaryota relationship: RO:0002592 GO:0005929 ! results in organization of cilium creation_date: 2013-03-27T15:09:58Z [Term] id: GO:0044848 name: biological phase namespace: biological_process def: "A distinct period or stage in a biological process or cycle." [GOC:jl] comment: Note that phases are is_a disjoint from other biological processes. happens_during relationships can operate between phases and other biological processes e.g. DNA replication happens_during S phase. subset: gocheck_do_not_annotate is_a: GO:0008150 ! biological_process disjoint_from: GO:0046879 ! hormone secretion disjoint_from: GO:0048511 ! rhythmic process disjoint_from: GO:0050896 ! response to stimulus disjoint_from: GO:0051179 ! localization disjoint_from: GO:0071840 ! cellular component organization or biogenesis creation_date: 2014-07-16T13:12:40Z [Term] id: GO:0044872 name: lipoprotein localization namespace: biological_process def: "Any process in which a lipoprotein is transported to, or maintained in, a specific location." [GOC:jl] is_a: BFO:0000003 is_a: GO:0033036 ! macromolecule localization intersection_of: GO:0051179 ! localization intersection_of: RO:0004009 CHEBI:6495 ! has primary input relationship: RO:0004009 CHEBI:6495 ! has primary input creation_date: 2014-11-25T16:27:06Z [Term] id: GO:0044873 name: lipoprotein localization to membrane namespace: biological_process def: "A process in which a lipoprotein is transported to, or maintained in, a specific location in a membrane." [GOC:jl] is_a: GO:0044872 ! lipoprotein localization is_a: GO:0051668 ! localization within membrane intersection_of: GO:0044872 ! lipoprotein localization intersection_of: RO:0002339 GO:0016020 ! has target end location membrane creation_date: 2014-11-25T16:28:43Z [Term] id: GO:0044874 name: lipoprotein localization to outer membrane namespace: biological_process def: "A process in which a lipoprotein is transported to, or maintained in, a specific location in an outer membrane." [GOC:jl] is_a: GO:0044873 ! lipoprotein localization to membrane intersection_of: GO:0044872 ! lipoprotein localization intersection_of: RO:0002339 GO:0019867 ! has target end location outer membrane relationship: RO:0002339 GO:0019867 ! has target end location outer membrane creation_date: 2014-11-25T16:30:30Z [Term] id: GO:0044877 name: protein-containing complex binding namespace: molecular_function def: "Binding to a macromolecular complex." [GOC:jl] subset: goslim_chembl synonym: "macromolecular complex binding" RELATED [] synonym: "protein complex binding" EXACT [] is_a: BFO:0000003 is_a: GO:0005488 ! binding intersection_of: GO:0005488 ! binding intersection_of: RO:0004009 GO:0032991 ! has primary input protein-containing complex relationship: RO:0004009 GO:0032991 ! has primary input protein-containing complex creation_date: 2014-12-16T11:38:58Z [Term] id: GO:0045009 name: chitosome namespace: cellular_component def: "An intracellular membrane-bounded particle found in fungi and containing chitin synthase; it synthesizes chitin microfibrils. Chitin synthase activity exists in chitosomes and they are proposed to act as a reservoir for regulated transport of chitin synthase enzymes to the division septum." [ISBN:0198506732, PMID:8970154] is_a: GO:0031410 ! cytoplasmic vesicle [Term] id: GO:0045019 name: negative regulation of nitric oxide biosynthetic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of nitric oxide." [GOC:go_curators] synonym: "down regulation of nitric oxide biosynthetic process" EXACT [] synonym: "down-regulation of nitric oxide biosynthetic process" EXACT [] synonym: "downregulation of nitric oxide biosynthetic process" EXACT [] synonym: "inhibition of nitric oxide biosynthetic process" NARROW [] synonym: "negative regulation of nitric oxide anabolism" EXACT [] synonym: "negative regulation of nitric oxide biosynthesis" EXACT [] synonym: "negative regulation of nitric oxide formation" EXACT [] synonym: "negative regulation of nitric oxide synthesis" EXACT [] is_a: GO:0009890 ! negative regulation of biosynthetic process is_a: GO:0045428 ! regulation of nitric oxide biosynthetic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0006809 ! negatively regulates nitric oxide biosynthetic process relationship: RO:0002212 GO:0006809 ! negatively regulates nitric oxide biosynthetic process [Term] id: GO:0045026 name: plasma membrane fusion namespace: biological_process def: "The joining of the lipid bilayer membrane that surround a cell with that of another cell, producing a single cell." [GOC:elh, GOC:mtg_muscle] synonym: "cell fusion" BROAD [] synonym: "cell-cell fusion" BROAD [] is_a: GO:0007009 ! plasma membrane organization is_a: GO:0061025 ! membrane fusion intersection_of: GO:0009987 ! cellular process intersection_of: RO:0012008 GO:0005886 ! results in fusion of plasma membrane relationship: RO:0012008 GO:0005886 ! results in fusion of plasma membrane [Term] id: GO:0045028 name: G protein-coupled purinergic nucleotide receptor activity namespace: molecular_function def: "Combining with a purine nucleotide and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:mah, PMID:9755289] synonym: "G protein coupled purinergic nucleotide receptor activity" EXACT [] synonym: "G-protein coupled purinergic nucleotide receptor activity" EXACT [] synonym: "P2Y" RELATED [] synonym: "P2Y receptor" RELATED [PMID:9755289] synonym: "purinergic nucleotide receptor activity, G protein coupled" EXACT [] synonym: "purinergic nucleotide receptor activity, G-protein coupled" EXACT [GOC:bf] is_a: GO:0001614 ! purinergic nucleotide receptor activity is_a: GO:0004930 ! G protein-coupled receptor activity intersection_of: GO:0004930 ! G protein-coupled receptor activity intersection_of: RO:0004009 CHEBI:26395 ! has primary input relationship: BFO:0000050 GO:0035589 ! part of G protein-coupled purinergic nucleotide receptor signaling pathway [Term] id: GO:0045031 name: G protein-coupled ATP receptor activity namespace: molecular_function def: "Combining with ATP and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:mah] synonym: "ATP-activated adenosine receptor activity" RELATED [] synonym: "ATP-activated nucleotide receptor activity" BROAD [] is_a: GO:0045028 ! G protein-coupled purinergic nucleotide receptor activity intersection_of: GO:0004930 ! G protein-coupled receptor activity intersection_of: RO:0004009 CHEBI:30616 ! has primary input relationship: RO:0004009 CHEBI:30616 ! has primary input [Term] id: GO:0045037 name: protein import into chloroplast stroma namespace: biological_process def: "The targeting and import of proteins into the chloroplast stroma. Import depends on ATP hydrolysis catalyzed by stromal chaperones. Chloroplast stromal proteins, such as the S subunit of rubisco, have a N-terminal stromal-import sequence of about 44 amino acids which is cleaved from the protein precursor after import." [ISBN:0716731363] synonym: "chloroplast stroma protein import" EXACT [] synonym: "protein transport into chloroplast stroma" EXACT [] is_a: GO:0071806 ! protein transmembrane transport is_a: GO:0072596 ! establishment of protein localization to chloroplast is_a: GO:0072598 ! protein localization to chloroplast intersection_of: GO:0055085 ! transmembrane transport intersection_of: RO:0002339 GO:0009570 ! has target end location chloroplast stroma intersection_of: RO:0004009 PR:000000001 ! has primary input protein relationship: RO:0002339 GO:0009570 ! has target end location chloroplast stroma [Term] id: GO:0045055 name: regulated exocytosis namespace: biological_process def: "A process of exocytosis in which soluble proteins and other substances are initially stored in secretory vesicles for later release. It is found mainly in cells that are specialized for secreting products such as hormones, neurotransmitters, or digestive enzymes rapidly on demand." [GOC:mah, ISBN:0716731363] synonym: "regulated secretory pathway" EXACT [] is_a: GO:0006887 ! exocytosis [Term] id: GO:0045058 name: T cell selection namespace: biological_process def: "The process in which T cells that express T cell receptors that are restricted by self MHC protein complexes and tolerant to self antigens are selected for further maturation." [ISBN:0781735149, PMID:12414722] synonym: "T lymphocyte selection" EXACT [] synonym: "T-cell selection" EXACT [] synonym: "T-lymphocyte selection" EXACT [] xref: Wikipedia:Thymocyte is_a: BFO:0000003 is_a: GO:0002376 ! immune system process relationship: BFO:0000050 GO:0030217 ! part of T cell differentiation relationship: has_participant CL:0000084 ! T cell [Term] id: GO:0045063 name: T-helper 1 cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized T cell acquires the specialized features of a T-helper 1 (Th1) cell. A Th1 cell is a CD4-positive, alpha-beta T cell that has the phenotype T-bet-positive and produces interferon-gamma." [CL:0000545, GOC:ebc] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "T-helper 1 cell development" RELATED [GOC:add] is_a: GO:0042093 ! T-helper cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000545 ! results in acquisition of features of T-helper 1 cell relationship: BFO:0000050 GO:0042088 ! part of T-helper 1 type immune response relationship: RO:0002315 CL:0000545 ! results in acquisition of features of T-helper 1 cell [Term] id: GO:0045064 name: T-helper 2 cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized T cell acquires specialized features of a T-helper 2 (Th2) cell. A Th2 cell is a CD4-positive, alpha-beta T cell that has the phenotype GATA-3-positive and produces interleukin-4." [CL:0000546, GOC:ebc] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "T-helper 2 cell development" RELATED [GOC:add] is_a: GO:0042093 ! T-helper cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000546 ! results in acquisition of features of T-helper 2 cell relationship: BFO:0000050 GO:0042092 ! part of type 2 immune response relationship: RO:0002315 CL:0000546 ! results in acquisition of features of T-helper 2 cell [Term] id: GO:0045065 name: cytotoxic T cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized T cell acquires specialized features of a cytotoxic T cell." [GOC:ai] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "cytotoxic T cell development" RELATED [GOC:add] synonym: "cytotoxic T lymphocyte selection" EXACT [] synonym: "cytotoxic T-cell selection" EXACT [] synonym: "cytotoxic T-lymphocyte selection" EXACT [] is_a: GO:0030217 ! T cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000910 ! results in acquisition of features of cytotoxic T cell relationship: RO:0002315 CL:0000910 ! results in acquisition of features of cytotoxic T cell [Term] id: GO:0045066 name: regulatory T cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized T cell acquires specialized features of a regulatory T cell. Regulatory T cells control or suppress immune responses through a variety of mechanisms and subsets include the CD4+CD25+ cell type as well as certain CD8+ cell types." [ISBN:0781735149] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "regulatory T cell development" RELATED [GOC:add] synonym: "regulatory T lymphocyte differentiation" EXACT [] synonym: "regulatory T-cell differentiation" EXACT [] synonym: "regulatory T-lymphocyte differentiation" EXACT [] synonym: "suppressor T cell differentiation" EXACT [] synonym: "suppressor T lymphocyte differentiation" EXACT [] synonym: "suppressor T-cell differentiation" EXACT [] synonym: "suppressor T-lymphocyte differentiation" EXACT [] is_a: GO:0030217 ! T cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000815 ! results in acquisition of features of regulatory T cell relationship: RO:0002315 CL:0000815 ! results in acquisition of features of regulatory T cell [Term] id: GO:0045087 name: innate immune response namespace: biological_process def: "Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens." [GO_REF:0000022, GOC:add, GOC:ebc, GOC:mtg_sensu] synonym: "innate immunity" EXACT [GOC:pg] synonym: "nonspecific immune response" EXACT [] xref: Reactome:R-HSA-168249 "Innate Immune System" xref: Wikipedia:Innate_immune_system is_a: GO:0006955 ! immune response is_a: GO:0140546 ! defense response to symbiont property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4751 [Term] id: GO:0045088 name: regulation of innate immune response namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the innate immune response, the organism's first line of defense against infection." [GOC:ebc] is_a: GO:0002831 ! regulation of response to biotic stimulus is_a: GO:0031347 ! regulation of defense response is_a: GO:0032101 ! regulation of response to external stimulus is_a: GO:0050776 ! regulation of immune response intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0045087 ! regulates innate immune response relationship: RO:0002211 GO:0045087 ! regulates innate immune response property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4751 [Term] id: GO:0045089 name: positive regulation of innate immune response namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the innate immune response, the organism's first line of defense against infection." [GOC:ebc] synonym: "stimulation of innate immune response" NARROW [] synonym: "up regulation of innate immune response" EXACT [] synonym: "up-regulation of innate immune response" EXACT [] synonym: "upregulation of innate immune response" EXACT [] is_a: GO:0002833 ! positive regulation of response to biotic stimulus is_a: GO:0031349 ! positive regulation of defense response is_a: GO:0032103 ! positive regulation of response to external stimulus is_a: GO:0045088 ! regulation of innate immune response is_a: GO:0050778 ! positive regulation of immune response intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0045087 ! positively regulates innate immune response relationship: RO:0002213 GO:0045087 ! positively regulates innate immune response property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4751 [Term] id: GO:0045095 name: keratin filament namespace: cellular_component def: "A filament composed of acidic and basic keratins (types I and II), typically expressed in epithelial cells. The keratins are the most diverse classes of IF proteins, with a large number of keratin isoforms being expressed. Each type of epithelium always expresses a characteristic combination of type I and type II keratins." [ISBN:0716731363] synonym: "acidic keratin" RELATED [] synonym: "basic/neutral keratin" RELATED [] is_a: GO:0005882 ! intermediate filament [Term] id: GO:0045103 name: intermediate filament-based process namespace: biological_process def: "Any cellular process that depends upon or alters the intermediate filament cytoskeleton, that part of the cytoskeleton comprising intermediate filaments and their associated proteins." [GOC:ai] is_a: GO:0009987 ! cellular process [Term] id: GO:0045104 name: intermediate filament cytoskeleton organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising intermediate filaments and their associated proteins." [GOC:ai] synonym: "intermediate filament cytoskeleton organisation" EXACT [] synonym: "intermediate filament cytoskeleton organization and biogenesis" RELATED [GOC:mah] is_a: GO:0007010 ! cytoskeleton organization is_a: GO:0045103 ! intermediate filament-based process intersection_of: GO:0016043 ! cellular component organization intersection_of: RO:0002592 GO:0045111 ! results in organization of intermediate filament cytoskeleton relationship: RO:0002592 GO:0045111 ! results in organization of intermediate filament cytoskeleton [Term] id: GO:0045109 name: intermediate filament organization namespace: biological_process def: "Control of the spatial distribution of intermediate filaments; includes organizing filaments into meshworks, bundles, or other structures, as by cross-linking." [GOC:ai] synonym: "intermediate filament organisation" EXACT [] is_a: GO:0045104 ! intermediate filament cytoskeleton organization is_a: GO:0097435 ! supramolecular fiber organization intersection_of: GO:0016043 ! cellular component organization intersection_of: RO:0002592 GO:0005882 ! results in organization of intermediate filament relationship: RO:0002592 GO:0005882 ! results in organization of intermediate filament [Term] id: GO:0045110 name: intermediate filament bundle assembly namespace: biological_process def: "The formation of the bundles of intermediate filaments. Intermediate filament-associated proteins (IFAPs) cross-link intermediate filaments with one another, forming a bundle or a network, and with other cell structures, including the plasma membrane. The organization of intermediate filaments and their supportive function in various cells types depends in large part on their linkage to other cell structures via IFAPs." [ISBN:0716731363] synonym: "tonofilament assembly" NARROW [] is_a: GO:0022607 ! cellular component assembly is_a: GO:0045109 ! intermediate filament organization intersection_of: GO:0022607 ! cellular component assembly intersection_of: RO:0002592 GO:0005882 ! results in organization of intermediate filament [Term] id: GO:0045111 name: intermediate filament cytoskeleton namespace: cellular_component def: "Cytoskeletal structure made from intermediate filaments, typically organized in the cytosol as an extended system that stretches from the nuclear envelope to the plasma membrane. Some intermediate filaments run parallel to the cell surface, while others traverse the cytosol; together they form an internal framework that helps support the shape and resilience of the cell." [ISBN:0716731363] is_a: GO:0005856 ! cytoskeleton [Term] id: GO:0045117 name: azole transmembrane transport namespace: biological_process def: "The directed movement of azoles, heterocyclic compounds found in many biologically important substances, across a lipid bilayer, across a membrane." [GOC:go_curators, ISBN:3527307206, Wikipedia:Azole] synonym: "azole transport" RELATED [] is_a: GO:0055085 ! transmembrane transport is_a: GO:0071705 ! nitrogen compound transport intersection_of: GO:0055085 ! transmembrane transport intersection_of: RO:0004009 CHEBI:68452 ! has primary input relationship: RO:0004009 CHEBI:68452 ! has primary input [Term] id: GO:0045120 name: pronucleus namespace: cellular_component def: "The nucleus of either the ovum or the spermatozoon following fertilization. Thus, in the fertilized ovum, there are two pronuclei, one originating from the ovum, the other from the spermatozoon that brought about fertilization; they approach each other, but do not fuse until just before the first cleavage, when each pronucleus loses its membrane to release its contents." [ISBN:0198506732] xref: Wikipedia:Pronucleus is_a: GO:0005634 ! nucleus relationship: RO:0002162 NCBITaxon:33208 ! in taxon Metazoa [Term] id: GO:0045124 name: regulation of bone resorption namespace: biological_process def: "Any process that modulates the frequency, rate or extent of bone tissue loss (resorption)." [GOC:ai] is_a: GO:0046850 ! regulation of bone remodeling intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0045453 ! regulates bone resorption relationship: RO:0002211 GO:0045453 ! regulates bone resorption [Term] id: GO:0045132 name: meiotic chromosome segregation namespace: biological_process def: "The process in which genetic material, in the form of chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets during M phase of the meiotic cell cycle." [GOC:ai, GOC:mah] is_a: GO:0098813 ! nuclear chromosome segregation is_a: GO:1903046 ! meiotic cell cycle process intersection_of: GO:0098813 ! nuclear chromosome segregation intersection_of: BFO:0000050 GO:0140013 ! part of meiotic nuclear division relationship: BFO:0000050 GO:0140013 ! part of meiotic nuclear division [Term] id: GO:0045137 name: development of primary sexual characteristics namespace: biological_process def: "The process whose specific outcome is the progression of the primary sexual characteristics over time, from their formation to the mature structures. The primary sexual characteristics are the testes in males and the ovaries in females and they develop in response to sex hormone secretion." [GOC:ai] is_a: GO:0003006 ! developmental process involved in reproduction relationship: BFO:0000050 GO:0007275 ! part of multicellular organism development relationship: BFO:0000050 GO:0007548 ! part of sex differentiation property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0045144 name: meiotic sister chromatid segregation namespace: biological_process def: "The cell cycle process in which sister chromatids are organized and then physically separated and randomly apportioned to two sets during the second division of the meiotic cell cycle." [GOC:ai, ISBN:0815316194] synonym: "meiosis II, chromosome segregation" EXACT [] is_a: GO:0000819 ! sister chromatid segregation is_a: GO:0045132 ! meiotic chromosome segregation is_a: GO:0070192 ! chromosome organization involved in meiotic cell cycle intersection_of: GO:0000819 ! sister chromatid segregation intersection_of: BFO:0000050 GO:0007135 ! part of meiosis II relationship: BFO:0000050 GO:0007135 ! part of meiosis II [Term] id: GO:0045165 name: cell fate commitment namespace: biological_process def: "The cellular developmental process by which a cell establishes the intrinsic character of a cell or tissue region irreversibly committing it to a particular fate." [ISBN:0716731185] comment: Note that this term was 'cell fate determination' but the term name was changed to better match its existing definition and the child term 'cell fate determination; GO:0001709' was also created. is_a: GO:0048869 ! cellular developmental process relationship: BFO:0000050 GO:0030154 ! part of cell differentiation property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/24390" xsd:anyURI [Term] id: GO:0045168 name: cell-cell signaling involved in cell fate commitment namespace: biological_process def: "Signaling at long or short range between cells that results in the commitment of a cell to a certain fate." [GOC:dph, GOC:go_curators, GOC:tb] synonym: "cell fate commitment, cell-cell signaling" EXACT [] synonym: "cell fate commitment, cell-cell signalling" EXACT [] synonym: "cell-cell signaling during in cell fate commitment" EXACT [] synonym: "cell-cell signaling resulting in cell fate commitment" EXACT [] synonym: "cell-cell signalling during cell fate commitment" EXACT [] synonym: "cell-cell signalling involved in cell fate specification" NARROW [GOC:dph, GOC:tb] synonym: "cell-cell signalling resulting in cell fate commitment" EXACT [] is_a: GO:0007267 ! cell-cell signaling intersection_of: GO:0007267 ! cell-cell signaling intersection_of: BFO:0000050 GO:0045165 ! part of cell fate commitment relationship: BFO:0000050 GO:0045165 ! part of cell fate commitment [Term] id: GO:0045177 name: apical part of cell namespace: cellular_component def: "The region of a polarized cell that forms a tip or is distal to a base. For example, in a polarized epithelial cell, the apical region has an exposed surface and lies opposite to the basal lamina that separates the epithelium from other tissue." [GOC:mah, ISBN:0815316194] subset: goslim_pir synonym: "apical region of cell" EXACT [GOC:krc] is_a: GO:0110165 ! cellular anatomical structure relationship: BFO:0000050 CL:0000000 ! part of cell [Term] id: GO:0045179 name: apical cortex namespace: cellular_component def: "The region that lies just beneath the plasma membrane on the apical edge of a cell." [GOC:bf] is_a: GO:0099738 ! cell cortex region intersection_of: GO:0099738 ! cell cortex region intersection_of: BFO:0000050 GO:0045177 ! part of apical part of cell relationship: BFO:0000050 GO:0045177 ! part of apical part of cell property_value: RO:0002161 NCBITaxon:4890 [Term] id: GO:0045184 name: establishment of protein localization namespace: biological_process def: "The directed movement of a protein to a specific location." [GOC:bf] synonym: "establishment of protein localisation" EXACT [GOC:mah] synonym: "protein positioning" EXACT [] synonym: "protein recruitment" EXACT [] is_a: BFO:0000003 is_a: GO:0051234 ! establishment of localization intersection_of: GO:0051234 ! establishment of localization intersection_of: RO:0004009 CHEBI:36080 ! has primary input relationship: RO:0004009 CHEBI:36080 ! has primary input [Term] id: GO:0045185 name: maintenance of protein location namespace: biological_process def: "Any process in which a protein is maintained in a location and prevented from moving elsewhere. These include sequestration, stabilization to prevent transport elsewhere and the active retrieval of proteins that do move away." [GOC:bf] synonym: "active protein retrieval" NARROW [] synonym: "maintenance of protein localization" RELATED [GOC:dph, GOC:tb] synonym: "protein retention" NARROW [] synonym: "protein sequestering" NARROW [] is_a: GO:0051235 ! maintenance of location relationship: BFO:0000050 GO:0008104 ! part of intracellular protein localization [Term] id: GO:0045190 name: isotype switching namespace: biological_process def: "The switching of activated B cells from IgM biosynthesis to biosynthesis of other isotypes of immunoglobulin, accomplished through a recombination process involving an intrachromosomal deletion involving switch regions that reside 5' of each constant region gene segment in the immunoglobulin heavy chain locus." [ISBN:0781735149] comment: Note that IgM and IgD can be coexpressed by B cells via an alternate splicing mechanism, but true recombinational isotype switching to IgD has been demonstrated as well. Note that this term is best used to annotate gene products which are involved in the mechanism of DNA recombination used in isotype switching, like the B cell specific Swap70 factor in the mouse, rather than gene products which promote isotype switching such as cytokines or co-stimulatory molecules, which should instead be annotated to 'regulation of isotype switching ; GO:0045191'. synonym: "class switch recombination" EXACT [] synonym: "class switching" EXACT [] synonym: "isotype switch recombination" EXACT [] xref: Wikipedia:Immunoglobulin_class_switching is_a: GO:0002204 ! somatic recombination of immunoglobulin genes involved in immune response is_a: GO:0002312 ! B cell activation involved in immune response [Term] id: GO:0045191 name: regulation of isotype switching namespace: biological_process def: "Any process that modulates the frequency, rate or extent of isotype switching." [GOC:ai] synonym: "regulation of class switch recombination" EXACT [] synonym: "regulation of class switching" EXACT [] synonym: "regulation of isotype switch recombination" EXACT [] is_a: GO:0000018 ! regulation of DNA recombination is_a: GO:0002637 ! regulation of immunoglobulin production is_a: GO:0002889 ! regulation of immunoglobulin mediated immune response is_a: GO:0050864 ! regulation of B cell activation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0045190 ! regulates isotype switching relationship: RO:0002211 GO:0045190 ! regulates isotype switching [Term] id: GO:0045196 name: establishment or maintenance of neuroblast polarity namespace: biological_process def: "Any cellular process that results in the specification, formation or maintenance of the apicobasal polarity of a neuroblast cell, a progenitor of the central nervous system." [GOC:bf, GOC:mah, GOC:mtg_sensu, PMID:19375318, PMID:20066083] synonym: "establishment and/or maintenance of neuroblast cell polarity" EXACT [] is_a: GO:0007163 ! establishment or maintenance of cell polarity relationship: BFO:0000050 GO:0055059 ! part of asymmetric neuroblast division [Term] id: GO:0045200 name: establishment of neuroblast polarity namespace: biological_process def: "The specification and formation of the apicobasal polarity of a neuroblast cell, a progenitor of the central nervous system." [GOC:bf, GOC:mtg_sensu] synonym: "establishment of neuroblast cell polarity" EXACT [] is_a: BFO:0000003 is_a: GO:0030010 ! establishment of cell polarity is_a: GO:0045196 ! establishment or maintenance of neuroblast polarity intersection_of: GO:0030010 ! establishment of cell polarity intersection_of: BFO:0000066 CL:0000031 ! occurs in neuroblast (sensu Vertebrata) relationship: BFO:0000066 CL:0000031 ! occurs in neuroblast (sensu Vertebrata) [Term] id: GO:0045202 name: synapse namespace: cellular_component def: "The junction between an axon of one neuron and a dendrite of another neuron, a muscle fiber or a glial cell. As the axon approaches the synapse it enlarges into a specialized structure, the presynaptic terminal bouton, which contains mitochondria and synaptic vesicles. At the tip of the terminal bouton is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic terminal bouton secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane." [GOC:aruk, ISBN:0198506732, PMID:24619342, PMID:29383328, PMID:31998110] subset: goslim_agr subset: goslim_drosophila subset: goslim_euk_cellular_processes_ribbon subset: goslim_flybase_ribbon subset: goslim_mouse subset: goslim_pir subset: goslim_synapse synonym: "electrotonic synapse" RELATED [NIF_Subcellular:sao1311109124] synonym: "mixed synapse" NARROW [NIF_Subcellular:sao1506103497] synonym: "synaptic junction" EXACT [] xref: NIF_Subcellular:sao914572699 xref: Wikipedia:Chemical_synapse is_a: GO:0030054 ! cell junction relationship: RO:0002162 NCBITaxon:33208 ! in taxon Metazoa [Term] id: GO:0045211 name: postsynaptic membrane namespace: cellular_component def: "A specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters cross the synaptic cleft and transmit the signal to the postsynaptic membrane." [ISBN:0198506732] subset: goslim_synapse synonym: "post-synaptic membrane" EXACT [] is_a: GO:0097060 ! synaptic membrane relationship: BFO:0000050 GO:0098794 ! part of postsynapse [Term] id: GO:0045214 name: sarcomere organization namespace: biological_process def: "The myofibril assembly process that results in the organization of muscle actomyosin into sarcomeres. The sarcomere is the repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs." [GOC:bf] synonym: "sarcomere alignment" EXACT [] synonym: "sarcomere organisation" EXACT [] is_a: GO:0031032 ! actomyosin structure organization intersection_of: GO:0016043 ! cellular component organization intersection_of: RO:0002592 GO:0030017 ! results in organization of sarcomere relationship: BFO:0000050 GO:0030239 ! part of myofibril assembly relationship: RO:0002592 GO:0030017 ! results in organization of sarcomere [Term] id: GO:0045216 name: cell-cell junction organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a cell-cell junction. A cell-cell junction is a specialized region of connection between two cells." [GOC:ai, GOC:dph, GOC:jl, GOC:mah] synonym: "cell-cell junction assembly and maintenance" EXACT [] synonym: "cell-cell junction biogenesis" RELATED [] synonym: "cell-cell junction organisation" EXACT [GOC:mah] synonym: "intercellular junction assembly and maintenance" EXACT [] xref: Reactome:R-HSA-421270 "Cell-cell junction organization" is_a: GO:0034330 ! cell junction organization intersection_of: GO:0034330 ! cell junction organization intersection_of: RO:0002592 GO:0005911 ! results in organization of cell-cell junction relationship: RO:0002592 GO:0005911 ! results in organization of cell-cell junction [Term] id: GO:0045229 name: external encapsulating structure organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of external structures that lie outside the plasma membrane and surround the entire cell." [GOC:ai, GOC:dph, GOC:jl, GOC:mah] subset: goslim_pir synonym: "external encapsulating structure organisation" EXACT [] synonym: "external encapsulating structure organization and biogenesis" EXACT [GOC:dph, GOC:jl, GOC:mah] is_a: GO:0016043 ! cellular component organization intersection_of: GO:0016043 ! cellular component organization intersection_of: RO:0002592 GO:0030312 ! results in organization of external encapsulating structure relationship: RO:0002592 GO:0030312 ! results in organization of external encapsulating structure [Term] id: GO:0045236 name: CXCR chemokine receptor binding namespace: molecular_function def: "Binding to a chemokine receptor in the CXCR family." [GOC:ceb, PMID:11910892] synonym: "alpha chemokine receptor binding" EXACT [] synonym: "alpha chemokine receptor ligand" NARROW [] synonym: "C-X-C chemokine receptor ligand" NARROW [] synonym: "CXC chemokine receptor ligand" NARROW [] is_a: GO:0042379 ! chemokine receptor binding [Term] id: GO:0045296 name: cadherin binding namespace: molecular_function def: "Binding to cadherin, a type I membrane protein involved in cell adhesion." [GOC:bf] is_a: GO:0050839 ! cell adhesion molecule binding intersection_of: GO:0005488 ! binding intersection_of: RO:0004009 PR:000001327 ! has primary input cadherin relationship: RO:0004009 PR:000001327 ! has primary input cadherin [Term] id: GO:0045314 name: regulation of compound eye photoreceptor development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of compound eye photoreceptor development." [GOC:bf] synonym: "regulation of eye photoreceptor development" BROAD [] is_a: GO:0042478 ! regulation of eye photoreceptor cell development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0042051 ! regulates compound eye photoreceptor development relationship: BFO:0000050 GO:0046532 ! part of regulation of photoreceptor cell differentiation relationship: RO:0002211 GO:0042051 ! regulates compound eye photoreceptor development [Term] id: GO:0045315 name: positive regulation of compound eye photoreceptor development namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of compound eye photoreceptor development." [GOC:bf] synonym: "activation of eye photoreceptor development" BROAD [] synonym: "positive regulation of eye photoreceptor development" BROAD [] synonym: "stimulation of eye photoreceptor development" BROAD [] synonym: "up regulation of eye photoreceptor development" BROAD [] synonym: "up-regulation of eye photoreceptor development" BROAD [] synonym: "upregulation of eye photoreceptor development" BROAD [] is_a: GO:0042479 ! positive regulation of eye photoreceptor cell development is_a: GO:0045314 ! regulation of compound eye photoreceptor development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0042051 ! positively regulates compound eye photoreceptor development relationship: RO:0002213 GO:0042051 ! positively regulates compound eye photoreceptor development [Term] id: GO:0045316 name: negative regulation of compound eye photoreceptor development namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of compound eye photoreceptor development." [GOC:bf] synonym: "down regulation of eye photoreceptor development" BROAD [] synonym: "down-regulation of eye photoreceptor development" BROAD [] synonym: "downregulation of eye photoreceptor development" BROAD [] synonym: "inhibition of eye photoreceptor development" BROAD [] synonym: "negative regulation of eye photoreceptor development" BROAD [] is_a: GO:0042480 ! negative regulation of eye photoreceptor cell development is_a: GO:0045314 ! regulation of compound eye photoreceptor development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0042051 ! negatively regulates compound eye photoreceptor development relationship: RO:0002212 GO:0042051 ! negatively regulates compound eye photoreceptor development [Term] id: GO:0045321 name: leukocyte activation namespace: biological_process def: "A change in morphology and behavior of a leukocyte resulting from exposure to a specific antigen, mitogen, cytokine, cellular ligand, or soluble factor." [GOC:add] synonym: "immune cell activation" EXACT [] synonym: "leucocyte activation" EXACT [] xref: Wikipedia:Immunologic_activation is_a: BFO:0000003 is_a: GO:0001775 ! cell activation is_a: GO:0002376 ! immune system process intersection_of: GO:0001775 ! cell activation intersection_of: RO:0004009 CL:0000738 ! has primary input leukocyte relationship: RO:0002162 NCBITaxon:7742 ! in taxon Vertebrata relationship: RO:0004009 CL:0000738 ! has primary input leukocyte [Term] id: GO:0045428 name: regulation of nitric oxide biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of nitric oxide." [GOC:go_curators] synonym: "regulation of nitric oxide anabolism" EXACT [] synonym: "regulation of nitric oxide biosynthesis" EXACT [] synonym: "regulation of nitric oxide formation" EXACT [] synonym: "regulation of nitric oxide synthesis" EXACT [] is_a: GO:0009889 ! regulation of biosynthetic process is_a: GO:0080164 ! regulation of nitric oxide metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0006809 ! regulates nitric oxide biosynthetic process relationship: RO:0002211 GO:0006809 ! regulates nitric oxide biosynthetic process [Term] id: GO:0045429 name: positive regulation of nitric oxide biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of nitric oxide." [GOC:go_curators] synonym: "activation of nitric oxide biosynthetic process" NARROW [] synonym: "positive regulation of nitric oxide anabolism" EXACT [] synonym: "positive regulation of nitric oxide biosynthesis" EXACT [] synonym: "positive regulation of nitric oxide formation" EXACT [] synonym: "positive regulation of nitric oxide synthesis" EXACT [] synonym: "stimulation of nitric oxide biosynthetic process" NARROW [] synonym: "up regulation of nitric oxide biosynthetic process" EXACT [] synonym: "up-regulation of nitric oxide biosynthetic process" EXACT [] synonym: "upregulation of nitric oxide biosynthetic process" EXACT [] is_a: GO:0009891 ! positive regulation of biosynthetic process is_a: GO:0045428 ! regulation of nitric oxide biosynthetic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0006809 ! positively regulates nitric oxide biosynthetic process relationship: RO:0002213 GO:0006809 ! positively regulates nitric oxide biosynthetic process [Term] id: GO:0045443 name: juvenile hormone secretion namespace: biological_process def: "The regulated release of juvenile hormones, the three sesquiterpenoid derivatives that function to maintain the larval state of insects at molting and that may be required for other processes, e.g. oogenesis." [GOC:go_curators, ISBN:0198547684] is_a: GO:0046865 ! terpenoid transport is_a: GO:0060986 ! endocrine hormone secretion is_a: GO:0140353 ! lipid export from cell intersection_of: GO:0046903 ! secretion intersection_of: RO:0004009 CHEBI:24943 ! has primary input relationship: RO:0004009 CHEBI:24943 ! has primary input property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0045444 name: fat cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of an adipocyte, an animal connective tissue cell specialized for the synthesis and storage of fat." [CL:0000136, GOC:go_curators] synonym: "adipocyte cell differentiation" EXACT [] synonym: "adipocyte differentiation" EXACT [] synonym: "adipogenesis" RELATED [] synonym: "adipose cell differentiation" EXACT [] is_a: GO:0030154 ! cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000136 ! results in acquisition of features of adipocyte relationship: RO:0002315 CL:0000136 ! results in acquisition of features of adipocyte [Term] id: GO:0045445 name: myoblast differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a myoblast. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into striated muscle fibers." [CL:0000056, GOC:go_curators, GOC:mtg_muscle] synonym: "myoblast cell differentiation" EXACT [] is_a: GO:0030154 ! cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000056 ! results in acquisition of features of myoblast relationship: BFO:0000050 GO:0061061 ! part of muscle structure development relationship: RO:0002315 CL:0000056 ! results in acquisition of features of myoblast [Term] id: GO:0045446 name: endothelial cell differentiation namespace: biological_process def: "The process in which a mesodermal, bone marrow or neural crest cell acquires specialized features of an endothelial cell, a thin flattened cell. A layer of such cells lines the inside surfaces of body cavities, blood vessels, and lymph vessels, making up the endothelium." [CL:0000115, GOC:go_curators] is_a: GO:0030855 ! epithelial cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000115 ! results in acquisition of features of endothelial cell relationship: BFO:0000050 GO:0003158 ! part of endothelium development relationship: RO:0002315 CL:0000115 ! results in acquisition of features of endothelial cell [Term] id: GO:0045453 name: bone resorption namespace: biological_process def: "The process in which specialized cells known as osteoclasts degrade the organic and inorganic portions of bone, and endocytose and transport the degradation products." [GOC:mah, PMID:10968780] xref: Wikipedia:Bone_resorption is_a: GO:0001894 ! tissue homeostasis relationship: BFO:0000050 GO:0046849 ! part of bone remodeling property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0045455 name: ecdysteroid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving ecdysteroids, a group of polyhydroxylated ketosteroids ubiquitous in insects and other arthropods, in which they initiate post-embryonic development, including the metamorphosis of immature forms and the development of the reproductive system and the maturation of oocytes in adult females." [ISBN:0198506732] synonym: "ecdysteroid metabolism" EXACT [] is_a: GO:0008202 ! steroid metabolic process is_a: GO:0042180 ! ketone metabolic process is_a: GO:0042445 ! hormone metabolic process intersection_of: GO:0008152 ! metabolic process intersection_of: RO:0004007 CHEBI:23897 ! has primary input or output relationship: BFO:0000050 GO:0002165 ! part of instar larval or pupal development relationship: RO:0004007 CHEBI:23897 ! has primary input or output [Term] id: GO:0045456 name: ecdysteroid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of ecdysteroids, a group of polyhydroxylated ketosteroids which initiate post-embryonic development." [GOC:go_curators] synonym: "ecdysteroid anabolism" EXACT [] synonym: "ecdysteroid biosynthesis" EXACT [] synonym: "ecdysteroid formation" EXACT [] synonym: "ecdysteroid synthesis" EXACT [] is_a: GO:0006694 ! steroid biosynthetic process is_a: GO:0042181 ! ketone biosynthetic process is_a: GO:0042446 ! hormone biosynthetic process is_a: GO:0045455 ! ecdysteroid metabolic process intersection_of: GO:0009058 ! biosynthetic process intersection_of: RO:0004008 CHEBI:23897 ! has primary output relationship: RO:0004008 CHEBI:23897 ! has primary output [Term] id: GO:0045457 name: ecdysteroid secretion namespace: biological_process def: "The regulated release of ecdysteroids, a group of polyhydroxylated ketosteroids which initiate post-embryonic development." [GOC:go_curators] is_a: GO:0035929 ! steroid hormone secretion intersection_of: GO:0046903 ! secretion intersection_of: RO:0004009 CHEBI:23897 ! has primary input relationship: RO:0004009 CHEBI:23897 ! has primary input property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0045463 name: R8 cell development namespace: biological_process def: "The process whose specific outcome is the progression of the R8 photoreceptor over time, from its formation to the mature structure. The R8 photoreceptor is the founding receptor of each ommatidium." [PMID:11880339] is_a: GO:0042051 ! compound eye photoreceptor development intersection_of: GO:0048468 ! cell development intersection_of: RO:0002296 CL:0000709 ! results in development of R8 photoreceptor cell relationship: BFO:0000050 GO:0045465 ! part of R8 cell differentiation relationship: RO:0002296 CL:0000709 ! results in development of R8 photoreceptor cell [Term] id: GO:0045465 name: R8 cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires the specialized features of the R8 photoreceptor." [PMID:11880339] is_a: GO:0001751 ! compound eye photoreceptor cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000709 ! results in acquisition of features of R8 photoreceptor cell relationship: RO:0002315 CL:0000709 ! results in acquisition of features of R8 photoreceptor cell [Term] id: GO:0045466 name: R7 cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires the specialized features of the R7 photoreceptor." [PMID:11880339] is_a: GO:0001751 ! compound eye photoreceptor cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000707 ! results in acquisition of features of R7 photoreceptor cell relationship: RO:0002315 CL:0000707 ! results in acquisition of features of R7 photoreceptor cell [Term] id: GO:0045467 name: R7 cell development namespace: biological_process def: "The process whose specific outcome is the progression of the R7 photoreceptor over time, from its formation to the mature structure. The R7 photoreceptor is the last photoreceptor to develop in the ommatidium." [PMID:11880339] is_a: GO:0042051 ! compound eye photoreceptor development intersection_of: GO:0048468 ! cell development intersection_of: RO:0002296 CL:0000707 ! results in development of R7 photoreceptor cell relationship: BFO:0000050 GO:0045466 ! part of R7 cell differentiation relationship: RO:0002296 CL:0000707 ! results in development of R7 photoreceptor cell [Term] id: GO:0045476 name: nurse cell apoptotic process namespace: biological_process def: "Any apoptotic process in a nurse cell. During late oogenesis, following the transfer of substances from the nurse cells to the oocyte, nurse cell remnants are cleared from the egg chamber by apoptotic process." [CL:0000026, GOC:mtg_apoptosis, PMID:11973306] synonym: "apoptosis of nurse cells" EXACT [] synonym: "invertebrate nurse cell apoptosis" NARROW [] synonym: "nurse cell apoptosis" NARROW [] synonym: "nurse cell programmed cell death by apoptosis" EXACT [] synonym: "programmed cell death of nurse cells by apoptosis" EXACT [] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0010623 ! programmed cell death involved in cell development is_a: GO:1902742 ! apoptotic process involved in development intersection_of: GO:0006915 ! apoptotic process intersection_of: BFO:0000050 GO:0048477 ! part of oogenesis intersection_of: BFO:0000066 CL:0000026 ! occurs in invertebrate nurse cell relationship: BFO:0000050 GO:0048477 ! part of oogenesis relationship: BFO:0000066 CL:0000026 ! occurs in invertebrate nurse cell [Term] id: GO:0045477 name: regulation of nurse cell apoptotic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of nurse cell apoptotic process." [GOC:mtg_apoptosis, PMID:11973306] synonym: "regulation of nurse cell apoptosis" NARROW [] is_a: GO:1904748 ! regulation of apoptotic process involved in development is_a: GO:2000241 ! regulation of reproductive process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0045476 ! regulates nurse cell apoptotic process relationship: RO:0002211 GO:0045476 ! regulates nurse cell apoptotic process [Term] id: GO:0045570 name: regulation of imaginal disc growth namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the growth of the imaginal disc." [GOC:go_curators] is_a: GO:0048638 ! regulation of developmental growth intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0007446 ! regulates imaginal disc growth relationship: RO:0002211 GO:0007446 ! regulates imaginal disc growth [Term] id: GO:0045571 name: negative regulation of imaginal disc growth namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of imaginal disc growth." [GOC:go_curators] synonym: "down regulation of imaginal disc growth" EXACT [] synonym: "down-regulation of imaginal disc growth" EXACT [] synonym: "downregulation of imaginal disc growth" EXACT [] synonym: "inhibition of imaginal disc growth" NARROW [] is_a: GO:0045570 ! regulation of imaginal disc growth is_a: GO:0048640 ! negative regulation of developmental growth intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0007446 ! negatively regulates imaginal disc growth relationship: RO:0002212 GO:0007446 ! negatively regulates imaginal disc growth [Term] id: GO:0045572 name: positive regulation of imaginal disc growth namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of imaginal disc growth." [GOC:go_curators] synonym: "activation of imaginal disc growth" NARROW [] synonym: "stimulation of imaginal disc growth" NARROW [] synonym: "up regulation of imaginal disc growth" EXACT [] synonym: "up-regulation of imaginal disc growth" EXACT [] synonym: "upregulation of imaginal disc growth" EXACT [] is_a: GO:0045570 ! regulation of imaginal disc growth is_a: GO:0048639 ! positive regulation of developmental growth intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0007446 ! positively regulates imaginal disc growth relationship: RO:0002213 GO:0007446 ! positively regulates imaginal disc growth [Term] id: GO:0045575 name: basophil activation namespace: biological_process def: "The change in morphology and behavior of a basophil resulting from exposure to a cytokine, chemokine, soluble factor, or to (at least in mammals) an antigen which the basophil has specifically bound via IgE bound to Fc-epsilonRI receptors." [GOC:mgi_curators, ISBN:0781735149] xref: Wikipedia:Basophil_activation is_a: GO:0036230 ! granulocyte activation intersection_of: GO:0001775 ! cell activation intersection_of: RO:0004009 CL:0000767 ! has primary input basophil relationship: RO:0004009 CL:0000767 ! has primary input basophil [Term] id: GO:0045576 name: mast cell activation namespace: biological_process def: "The change in morphology and behavior of a mast cell resulting from exposure to a cytokine, chemokine, soluble factor, or to (at least in mammals) an antigen which the mast cell has specifically bound via IgE bound to Fc-epsilonRI receptors." [GOC:mgi_curators, ISBN:0781735149] is_a: GO:0002274 ! myeloid leukocyte activation intersection_of: GO:0001775 ! cell activation intersection_of: RO:0004009 CL:0000097 ! has primary input mast cell relationship: RO:0004009 CL:0000097 ! has primary input mast cell [Term] id: GO:0045577 name: regulation of B cell differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of B cell differentiation." [GOC:go_curators] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "regulation of B cell development" RELATED [GOC:add] synonym: "regulation of B lymphocyte differentiation" EXACT [] synonym: "regulation of B-cell differentiation" EXACT [] synonym: "regulation of B-lymphocyte differentiation" EXACT [] is_a: GO:0045619 ! regulation of lymphocyte differentiation is_a: GO:0050864 ! regulation of B cell activation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0030183 ! regulates B cell differentiation relationship: RO:0002211 GO:0030183 ! regulates B cell differentiation [Term] id: GO:0045578 name: negative regulation of B cell differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of B cell differentiation." [GOC:go_curators] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "down regulation of B cell differentiation" EXACT [] synonym: "down-regulation of B cell differentiation" EXACT [] synonym: "downregulation of B cell differentiation" EXACT [] synonym: "inhibition of B cell differentiation" NARROW [] synonym: "negative regulation of B cell development" RELATED [GOC:add] synonym: "negative regulation of B lymphocyte differentiation" EXACT [] synonym: "negative regulation of B-cell differentiation" EXACT [] synonym: "negative regulation of B-lymphocyte differentiation" EXACT [] is_a: GO:0045577 ! regulation of B cell differentiation is_a: GO:0045620 ! negative regulation of lymphocyte differentiation is_a: GO:0050869 ! negative regulation of B cell activation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0030183 ! negatively regulates B cell differentiation relationship: RO:0002212 GO:0030183 ! negatively regulates B cell differentiation [Term] id: GO:0045579 name: positive regulation of B cell differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of B cell differentiation." [GOC:go_curators] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "activation of B cell differentiation" NARROW [] synonym: "positive regulation of B cell development" RELATED [GOC:add] synonym: "positive regulation of B lymphocyte differentiation" EXACT [] synonym: "positive regulation of B-cell differentiation" EXACT [] synonym: "positive regulation of B-lymphocyte differentiation" EXACT [] synonym: "stimulation of B cell differentiation" NARROW [] synonym: "up regulation of B cell differentiation" EXACT [] synonym: "up-regulation of B cell differentiation" EXACT [] synonym: "upregulation of B cell differentiation" EXACT [] is_a: GO:0045577 ! regulation of B cell differentiation is_a: GO:0045621 ! positive regulation of lymphocyte differentiation is_a: GO:0050871 ! positive regulation of B cell activation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0030183 ! positively regulates B cell differentiation relationship: RO:0002213 GO:0030183 ! positively regulates B cell differentiation [Term] id: GO:0045580 name: regulation of T cell differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of T cell differentiation." [GOC:go_curators] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "regulation of T cell development" RELATED [GOC:add] synonym: "regulation of T lymphocyte differentiation" EXACT [] synonym: "regulation of T-cell differentiation" EXACT [] synonym: "regulation of T-lymphocyte differentiation" EXACT [] is_a: GO:0045619 ! regulation of lymphocyte differentiation is_a: GO:0050863 ! regulation of T cell activation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0030217 ! regulates T cell differentiation relationship: RO:0002211 GO:0030217 ! regulates T cell differentiation [Term] id: GO:0045581 name: negative regulation of T cell differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of T cell differentiation." [GOC:go_curators] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "down regulation of T cell differentiation" EXACT [] synonym: "down-regulation of T cell differentiation" EXACT [] synonym: "downregulation of T cell differentiation" EXACT [] synonym: "inhibition of T cell differentiation" NARROW [] synonym: "negative regulation of T cell development" RELATED [GOC:add] synonym: "negative regulation of T lymphocyte differentiation" EXACT [] synonym: "negative regulation of T-cell differentiation" EXACT [] synonym: "negative regulation of T-lymphocyte differentiation" EXACT [] is_a: GO:0045580 ! regulation of T cell differentiation is_a: GO:0045620 ! negative regulation of lymphocyte differentiation is_a: GO:0050868 ! negative regulation of T cell activation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0030217 ! negatively regulates T cell differentiation relationship: RO:0002212 GO:0030217 ! negatively regulates T cell differentiation [Term] id: GO:0045582 name: positive regulation of T cell differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of T cell differentiation." [GOC:go_curators] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "activation of T cell differentiation" NARROW [] synonym: "positive regulation of T cell development" RELATED [GOC:add] synonym: "positive regulation of T lymphocyte differentiation" EXACT [] synonym: "positive regulation of T-cell differentiation" EXACT [] synonym: "positive regulation of T-lymphocyte differentiation" EXACT [] synonym: "stimulation of T cell differentiation" NARROW [] synonym: "up regulation of T cell differentiation" EXACT [] synonym: "up-regulation of T cell differentiation" EXACT [] synonym: "upregulation of T cell differentiation" EXACT [] is_a: GO:0045580 ! regulation of T cell differentiation is_a: GO:0045621 ! positive regulation of lymphocyte differentiation is_a: GO:0050870 ! positive regulation of T cell activation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0030217 ! positively regulates T cell differentiation relationship: RO:0002213 GO:0030217 ! positively regulates T cell differentiation [Term] id: GO:0045583 name: regulation of cytotoxic T cell differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cytotoxic T cell differentiation." [GOC:go_curators] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "regulation of cytotoxic T cell development" RELATED [GOC:add] synonym: "regulation of cytotoxic T lymphocyte differentiation" EXACT [] synonym: "regulation of cytotoxic T-cell differentiation" EXACT [] synonym: "regulation of cytotoxic T-lymphocyte differentiation" EXACT [] is_a: GO:0045580 ! regulation of T cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0045065 ! regulates cytotoxic T cell differentiation relationship: RO:0002211 GO:0045065 ! regulates cytotoxic T cell differentiation [Term] id: GO:0045584 name: negative regulation of cytotoxic T cell differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cytotoxic T cell differentiation." [GOC:go_curators] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "down regulation of cytotoxic T cell differentiation" EXACT [] synonym: "down-regulation of cytotoxic T cell differentiation" EXACT [] synonym: "downregulation of cytotoxic T cell differentiation" EXACT [] synonym: "inhibition of cytotoxic T cell differentiation" NARROW [] synonym: "negative regulation of cytotoxic T cell development" RELATED [GOC:add] synonym: "negative regulation of cytotoxic T lymphocyte differentiation" EXACT [] synonym: "negative regulation of cytotoxic T-cell differentiation" EXACT [] synonym: "negative regulation of cytotoxic T-lymphocyte differentiation" EXACT [] is_a: GO:0045581 ! negative regulation of T cell differentiation is_a: GO:0045583 ! regulation of cytotoxic T cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0045065 ! negatively regulates cytotoxic T cell differentiation relationship: RO:0002212 GO:0045065 ! negatively regulates cytotoxic T cell differentiation [Term] id: GO:0045585 name: positive regulation of cytotoxic T cell differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cytotoxic T cell differentiation." [GOC:go_curators] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "activation of cytotoxic T cell differentiation" NARROW [] synonym: "positive regulation of cytotoxic T cell development" RELATED [GOC:add] synonym: "positive regulation of cytotoxic T lymphocyte differentiation" EXACT [] synonym: "positive regulation of cytotoxic T-cell differentiation" EXACT [] synonym: "positive regulation of cytotoxic T-lymphocyte differentiation" EXACT [] synonym: "stimulation of cytotoxic T cell differentiation" NARROW [] synonym: "up regulation of cytotoxic T cell differentiation" EXACT [] synonym: "up-regulation of cytotoxic T cell differentiation" EXACT [] synonym: "upregulation of cytotoxic T cell differentiation" EXACT [] is_a: GO:0045582 ! positive regulation of T cell differentiation is_a: GO:0045583 ! regulation of cytotoxic T cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0045065 ! positively regulates cytotoxic T cell differentiation relationship: RO:0002213 GO:0045065 ! positively regulates cytotoxic T cell differentiation [Term] id: GO:0045586 name: regulation of gamma-delta T cell differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of gamma-delta T cell differentiation." [GOC:go_curators] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "regulation of gamma-delta T cell development" RELATED [GOC:add] synonym: "regulation of gamma-delta T lymphocyte differentiation" EXACT [] synonym: "regulation of gamma-delta T-cell differentiation" EXACT [] synonym: "regulation of gamma-delta T-lymphocyte differentiation" EXACT [] is_a: GO:0045580 ! regulation of T cell differentiation is_a: GO:0046643 ! regulation of gamma-delta T cell activation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0042492 ! regulates gamma-delta T cell differentiation relationship: RO:0002211 GO:0042492 ! regulates gamma-delta T cell differentiation [Term] id: GO:0045587 name: negative regulation of gamma-delta T cell differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of gamma-delta T cell differentiation." [GOC:go_curators] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "down regulation of gamma-delta T cell differentiation" EXACT [] synonym: "down-regulation of gamma-delta T cell differentiation" EXACT [] synonym: "downregulation of gamma-delta T cell differentiation" EXACT [] synonym: "inhibition of gamma-delta T cell differentiation" NARROW [] synonym: "negative regulation of gamma-delta T cell development" RELATED [GOC:add] synonym: "negative regulation of gamma-delta T lymphocyte differentiation" EXACT [] synonym: "negative regulation of gamma-delta T-cell differentiation" EXACT [] synonym: "negative regulation of gamma-delta T-lymphocyte differentiation" EXACT [] is_a: GO:0045581 ! negative regulation of T cell differentiation is_a: GO:0045586 ! regulation of gamma-delta T cell differentiation is_a: GO:0046644 ! negative regulation of gamma-delta T cell activation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0042492 ! negatively regulates gamma-delta T cell differentiation relationship: RO:0002212 GO:0042492 ! negatively regulates gamma-delta T cell differentiation [Term] id: GO:0045588 name: positive regulation of gamma-delta T cell differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of gamma-delta T cell differentiation." [GOC:go_curators] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "activation of gamma-delta T cell differentiation" NARROW [] synonym: "positive regulation of gamma-delta T cell development" RELATED [GOC:add] synonym: "positive regulation of gamma-delta T lymphocyte differentiation" EXACT [] synonym: "positive regulation of gamma-delta T-cell differentiation" EXACT [] synonym: "positive regulation of gamma-delta T-lymphocyte differentiation" EXACT [] synonym: "stimulation of gamma-delta T cell differentiation" NARROW [] synonym: "up regulation of gamma-delta T cell differentiation" EXACT [] synonym: "up-regulation of gamma-delta T cell differentiation" EXACT [] synonym: "upregulation of gamma-delta T cell differentiation" EXACT [] is_a: GO:0045582 ! positive regulation of T cell differentiation is_a: GO:0045586 ! regulation of gamma-delta T cell differentiation is_a: GO:0046645 ! positive regulation of gamma-delta T cell activation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0042492 ! positively regulates gamma-delta T cell differentiation relationship: RO:0002213 GO:0042492 ! positively regulates gamma-delta T cell differentiation [Term] id: GO:0045589 name: regulation of regulatory T cell differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of differentiation of regulatory T cells." [ISBN:0781735149] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "regulation of regulatory T cell development" RELATED [GOC:add] synonym: "regulation of regulatory T lymphocyte differentiation" EXACT [] synonym: "regulation of regulatory T-cell differentiation" EXACT [] synonym: "regulation of regulatory T-lymphocyte differentiation" EXACT [] synonym: "regulation of suppressor T cell differentiation" EXACT [] synonym: "regulation of suppressor T lymphocyte differentiation" EXACT [] synonym: "regulation of suppressor T-cell differentiation" EXACT [] synonym: "regulation of suppressor T-lymphocyte differentiation" EXACT [] xref: Reactome:R-HSA-8877330 "RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)" is_a: GO:0045580 ! regulation of T cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0045066 ! regulates regulatory T cell differentiation relationship: RO:0002211 GO:0045066 ! regulates regulatory T cell differentiation [Term] id: GO:0045590 name: negative regulation of regulatory T cell differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the rate of differentiation of regulatory T cells." [ISBN:0781735149] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "down regulation of regulatory T cell differentiation" EXACT [] synonym: "down-regulation of regulatory T cell differentiation" EXACT [] synonym: "downregulation of regulatory T cell differentiation" EXACT [] synonym: "inhibition of regulatory T cell differentiation" NARROW [] synonym: "negative regulation of regulatory T cell development" RELATED [GOC:add] synonym: "negative regulation of regulatory T lymphocyte differentiation" EXACT [] synonym: "negative regulation of regulatory T-cell differentiation" EXACT [] synonym: "negative regulation of regulatory T-lymphocyte differentiation" EXACT [] synonym: "negative regulation of suppressor T cell differentiation" EXACT [] synonym: "negative regulation of suppressor T-cell differentiation" EXACT [] is_a: GO:0045581 ! negative regulation of T cell differentiation is_a: GO:0045589 ! regulation of regulatory T cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0045066 ! negatively regulates regulatory T cell differentiation relationship: RO:0002212 GO:0045066 ! negatively regulates regulatory T cell differentiation [Term] id: GO:0045591 name: positive regulation of regulatory T cell differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of differentiation of regulatory T cells." [ISBN:0781735149] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "activation of regulatory T cell differentiation" NARROW [] synonym: "positive regulation of regulatory T cell development" RELATED [GOC:add] synonym: "positive regulation of regulatory T lymphocyte differentiation" EXACT [] synonym: "positive regulation of regulatory T-cell differentiation" EXACT [] synonym: "positive regulation of regulatory T-lymphocyte differentiation" EXACT [] synonym: "positive regulation of suppressor T cell differentiation" EXACT [] synonym: "positive regulation of suppressor T-cell differentiation" EXACT [] synonym: "stimulation of regulatory T cell differentiation" NARROW [] synonym: "up regulation of regulatory T cell differentiation" EXACT [] synonym: "up-regulation of regulatory T cell differentiation" EXACT [] synonym: "upregulation of regulatory T cell differentiation" EXACT [] is_a: GO:0045582 ! positive regulation of T cell differentiation is_a: GO:0045589 ! regulation of regulatory T cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0045066 ! positively regulates regulatory T cell differentiation relationship: RO:0002213 GO:0045066 ! positively regulates regulatory T cell differentiation [Term] id: GO:0045592 name: regulation of cumulus cell differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of ovarian cumulus cell differentiation." [GOC:go_curators] synonym: "regulation of ovarian cumulus cell differentiation" EXACT [] is_a: GO:0030856 ! regulation of epithelial cell differentiation is_a: GO:2000387 ! regulation of antral ovarian follicle growth intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0001549 ! regulates cumulus cell differentiation relationship: RO:0002211 GO:0001549 ! regulates cumulus cell differentiation [Term] id: GO:0045593 name: negative regulation of cumulus cell differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of ovarian cumulus cell differentiation." [GOC:go_curators] synonym: "down regulation of cumulus cell differentiation" EXACT [] synonym: "down-regulation of cumulus cell differentiation" EXACT [] synonym: "downregulation of cumulus cell differentiation" EXACT [] synonym: "inhibition of cumulus cell differentiation" NARROW [] synonym: "negative regulation of ovarian cumulus cell differentiation" EXACT [] is_a: GO:0030857 ! negative regulation of epithelial cell differentiation is_a: GO:0045592 ! regulation of cumulus cell differentiation is_a: GO:2000242 ! negative regulation of reproductive process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0001549 ! negatively regulates cumulus cell differentiation relationship: RO:0002212 GO:0001549 ! negatively regulates cumulus cell differentiation [Term] id: GO:0045594 name: positive regulation of cumulus cell differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of ovarian cumulus cell differentiation." [GOC:go_curators] synonym: "activation of cumulus cell differentiation" NARROW [] synonym: "positive regulation of ovarian cumulus cell differentiation" EXACT [] synonym: "stimulation of cumulus cell differentiation" NARROW [] synonym: "up regulation of cumulus cell differentiation" EXACT [] synonym: "up-regulation of cumulus cell differentiation" EXACT [] synonym: "upregulation of cumulus cell differentiation" EXACT [] is_a: GO:0030858 ! positive regulation of epithelial cell differentiation is_a: GO:0045592 ! regulation of cumulus cell differentiation is_a: GO:2000243 ! positive regulation of reproductive process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0001549 ! positively regulates cumulus cell differentiation relationship: RO:0002213 GO:0001549 ! positively regulates cumulus cell differentiation [Term] id: GO:0045595 name: regulation of cell differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cell differentiation, the process in which relatively unspecialized cells acquire specialized structural and functional features." [GOC:go_curators] is_a: GO:0050793 ! regulation of developmental process is_a: GO:0050794 ! regulation of cellular process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0030154 ! regulates cell differentiation relationship: RO:0002211 GO:0030154 ! regulates cell differentiation [Term] id: GO:0045596 name: negative regulation of cell differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cell differentiation." [GOC:go_curators] synonym: "down regulation of cell differentiation" EXACT [] synonym: "down-regulation of cell differentiation" EXACT [] synonym: "downregulation of cell differentiation" EXACT [] synonym: "inhibition of cell differentiation" NARROW [] is_a: GO:0045595 ! regulation of cell differentiation is_a: GO:0048523 ! negative regulation of cellular process is_a: GO:0051093 ! negative regulation of developmental process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0030154 ! negatively regulates cell differentiation relationship: RO:0002212 GO:0030154 ! negatively regulates cell differentiation [Term] id: GO:0045597 name: positive regulation of cell differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cell differentiation." [GOC:go_curators] synonym: "activation of cell differentiation" NARROW [] synonym: "stimulation of cell differentiation" NARROW [] synonym: "up regulation of cell differentiation" EXACT [] synonym: "up-regulation of cell differentiation" EXACT [] synonym: "upregulation of cell differentiation" EXACT [] is_a: GO:0045595 ! regulation of cell differentiation is_a: GO:0048522 ! positive regulation of cellular process is_a: GO:0051094 ! positive regulation of developmental process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0030154 ! positively regulates cell differentiation relationship: RO:0002213 GO:0030154 ! positively regulates cell differentiation [Term] id: GO:0045598 name: regulation of fat cell differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of adipocyte differentiation." [GOC:go_curators] synonym: "regulation of adipocyte cell differentiation" EXACT [] synonym: "regulation of adipocyte differentiation" EXACT [] is_a: GO:0045595 ! regulation of cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0045444 ! regulates fat cell differentiation relationship: RO:0002211 GO:0045444 ! regulates fat cell differentiation [Term] id: GO:0045599 name: negative regulation of fat cell differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of adipocyte differentiation." [GOC:go_curators] synonym: "down regulation of fat cell differentiation" EXACT [] synonym: "down-regulation of fat cell differentiation" EXACT [] synonym: "downregulation of fat cell differentiation" EXACT [] synonym: "inhibition of fat cell differentiation" NARROW [] synonym: "negative regulation of adipocyte cell differentiation" EXACT [] synonym: "negative regulation of adipocyte differentiation" EXACT [] is_a: GO:0045596 ! negative regulation of cell differentiation is_a: GO:0045598 ! regulation of fat cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0045444 ! negatively regulates fat cell differentiation relationship: RO:0002212 GO:0045444 ! negatively regulates fat cell differentiation [Term] id: GO:0045600 name: positive regulation of fat cell differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of adipocyte differentiation." [GOC:go_curators] synonym: "activation of fat cell differentiation" NARROW [] synonym: "positive regulation of adipocyte cell differentiation" EXACT [] synonym: "positive regulation of adipocyte differentiation" EXACT [] synonym: "stimulation of fat cell differentiation" NARROW [] synonym: "up regulation of fat cell differentiation" EXACT [] synonym: "up-regulation of fat cell differentiation" EXACT [] synonym: "upregulation of fat cell differentiation" EXACT [] is_a: GO:0045597 ! positive regulation of cell differentiation is_a: GO:0045598 ! regulation of fat cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0045444 ! positively regulates fat cell differentiation relationship: RO:0002213 GO:0045444 ! positively regulates fat cell differentiation [Term] id: GO:0045601 name: regulation of endothelial cell differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of endothelial cell differentiation." [GOC:go_curators] is_a: GO:0030856 ! regulation of epithelial cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0045446 ! regulates endothelial cell differentiation relationship: RO:0002211 GO:0045446 ! regulates endothelial cell differentiation [Term] id: GO:0045602 name: negative regulation of endothelial cell differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of endothelial cell differentiation." [GOC:go_curators] synonym: "down regulation of endothelial cell differentiation" EXACT [] synonym: "down-regulation of endothelial cell differentiation" EXACT [] synonym: "downregulation of endothelial cell differentiation" EXACT [] synonym: "inhibition of endothelial cell differentiation" NARROW [] is_a: GO:0030857 ! negative regulation of epithelial cell differentiation is_a: GO:0045601 ! regulation of endothelial cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0045446 ! negatively regulates endothelial cell differentiation relationship: RO:0002212 GO:0045446 ! negatively regulates endothelial cell differentiation [Term] id: GO:0045603 name: positive regulation of endothelial cell differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of endothelial cell differentiation." [GOC:go_curators] synonym: "activation of endothelial cell differentiation" NARROW [] synonym: "stimulation of endothelial cell differentiation" NARROW [] synonym: "up regulation of endothelial cell differentiation" EXACT [] synonym: "up-regulation of endothelial cell differentiation" EXACT [] synonym: "upregulation of endothelial cell differentiation" EXACT [] is_a: GO:0030858 ! positive regulation of epithelial cell differentiation is_a: GO:0045601 ! regulation of endothelial cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0045446 ! positively regulates endothelial cell differentiation relationship: RO:0002213 GO:0045446 ! positively regulates endothelial cell differentiation [Term] id: GO:0045604 name: regulation of epidermal cell differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of epidermal cell differentiation." [GOC:go_curators] synonym: "regulation of hypodermal cell differentiation" RELATED [GOC:kmv, GOC:rk] is_a: GO:0030856 ! regulation of epithelial cell differentiation is_a: GO:0045682 ! regulation of epidermis development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0009913 ! regulates epidermal cell differentiation relationship: RO:0002211 GO:0009913 ! regulates epidermal cell differentiation [Term] id: GO:0045605 name: negative regulation of epidermal cell differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of epidermal cell differentiation." [GOC:go_curators] synonym: "down regulation of epidermal cell differentiation" EXACT [] synonym: "down-regulation of epidermal cell differentiation" EXACT [] synonym: "downregulation of epidermal cell differentiation" EXACT [] synonym: "inhibition of epidermal cell differentiation" NARROW [] synonym: "negative regulation of hypodermal cell differentiation" RELATED [GOC:kmv, GOC:rk] is_a: GO:0030857 ! negative regulation of epithelial cell differentiation is_a: GO:0045604 ! regulation of epidermal cell differentiation is_a: GO:0045683 ! negative regulation of epidermis development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0009913 ! negatively regulates epidermal cell differentiation relationship: RO:0002212 GO:0009913 ! negatively regulates epidermal cell differentiation [Term] id: GO:0045606 name: positive regulation of epidermal cell differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of epidermal cell differentiation." [GOC:go_curators] synonym: "activation of epidermal cell differentiation" NARROW [] synonym: "positive regulation of hypodermal cell differentiation" RELATED [GOC:kmv, GOC:rk] synonym: "stimulation of epidermal cell differentiation" NARROW [] synonym: "up regulation of epidermal cell differentiation" EXACT [] synonym: "up-regulation of epidermal cell differentiation" EXACT [] synonym: "upregulation of epidermal cell differentiation" EXACT [] is_a: GO:0030858 ! positive regulation of epithelial cell differentiation is_a: GO:0045604 ! regulation of epidermal cell differentiation is_a: GO:0045684 ! positive regulation of epidermis development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0009913 ! positively regulates epidermal cell differentiation relationship: RO:0002213 GO:0009913 ! positively regulates epidermal cell differentiation [Term] id: GO:0045607 name: regulation of inner ear auditory receptor cell differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of auditory hair cell differentiation." [GOC:go_curators] synonym: "regulation of auditory hair cell differentiation" EXACT [] synonym: "regulation of auditory receptor cell differentiation" RELATED [] is_a: GO:0045604 ! regulation of epidermal cell differentiation is_a: GO:2000980 ! regulation of inner ear receptor cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0042491 ! regulates inner ear auditory receptor cell differentiation relationship: RO:0002211 GO:0042491 ! regulates inner ear auditory receptor cell differentiation [Term] id: GO:0045608 name: negative regulation of inner ear auditory receptor cell differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of auditory hair cell differentiation." [GOC:go_curators] synonym: "down regulation of auditory receptor cell differentiation" EXACT [] synonym: "down-regulation of auditory receptor cell differentiation" EXACT [] synonym: "downregulation of auditory receptor cell differentiation" EXACT [] synonym: "inhibition of auditory receptor cell differentiation" NARROW [] synonym: "negative regulation of auditory hair cell differentiation" EXACT [] synonym: "negative regulation of auditory receptor cell differentiation" RELATED [] is_a: GO:0045605 ! negative regulation of epidermal cell differentiation is_a: GO:0045607 ! regulation of inner ear auditory receptor cell differentiation is_a: GO:2000981 ! negative regulation of inner ear receptor cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0042491 ! negatively regulates inner ear auditory receptor cell differentiation relationship: RO:0002212 GO:0042491 ! negatively regulates inner ear auditory receptor cell differentiation [Term] id: GO:0045609 name: positive regulation of inner ear auditory receptor cell differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of auditory hair cell differentiation." [GOC:go_curators] synonym: "activation of auditory receptor cell differentiation" NARROW [] synonym: "positive regulation of auditory hair cell differentiation" EXACT [] synonym: "positive regulation of auditory receptor cell differentiation" RELATED [] synonym: "stimulation of auditory receptor cell differentiation" NARROW [] synonym: "up regulation of auditory receptor cell differentiation" EXACT [] synonym: "up-regulation of auditory receptor cell differentiation" EXACT [] synonym: "upregulation of auditory receptor cell differentiation" EXACT [] is_a: GO:0045606 ! positive regulation of epidermal cell differentiation is_a: GO:0045607 ! regulation of inner ear auditory receptor cell differentiation is_a: GO:2000982 ! positive regulation of inner ear receptor cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0042491 ! positively regulates inner ear auditory receptor cell differentiation relationship: RO:0002213 GO:0042491 ! positively regulates inner ear auditory receptor cell differentiation [Term] id: GO:0045610 name: regulation of hemocyte differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of hemocyte differentiation." [GOC:go_curators] synonym: "regulation of arthropod blood cell differentiation" EXACT [] is_a: GO:0002682 ! regulation of immune system process is_a: GO:0045595 ! regulation of cell differentiation is_a: GO:0051239 ! regulation of multicellular organismal process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0042386 ! regulates hemocyte differentiation relationship: RO:0002211 GO:0042386 ! regulates hemocyte differentiation [Term] id: GO:0045611 name: negative regulation of hemocyte differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of hemocyte differentiation." [GOC:go_curators] synonym: "down regulation of hemocyte differentiation" EXACT [] synonym: "down-regulation of hemocyte differentiation" EXACT [] synonym: "downregulation of hemocyte differentiation" EXACT [] synonym: "inhibition of hemocyte differentiation" NARROW [] synonym: "negative regulation of arthropod blood cell differentiation" EXACT [] is_a: GO:0002683 ! negative regulation of immune system process is_a: GO:0045596 ! negative regulation of cell differentiation is_a: GO:0045610 ! regulation of hemocyte differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0042386 ! negatively regulates hemocyte differentiation relationship: RO:0002212 GO:0042386 ! negatively regulates hemocyte differentiation [Term] id: GO:0045612 name: positive regulation of hemocyte differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of hemocyte differentiation." [GOC:go_curators] synonym: "activation of hemocyte differentiation" NARROW [] synonym: "positive regulation of arthropod blood cell differentiation" EXACT [] synonym: "stimulation of hemocyte differentiation" NARROW [] synonym: "up regulation of hemocyte differentiation" EXACT [] synonym: "up-regulation of hemocyte differentiation" EXACT [] synonym: "upregulation of hemocyte differentiation" EXACT [] is_a: GO:0002684 ! positive regulation of immune system process is_a: GO:0045597 ! positive regulation of cell differentiation is_a: GO:0045610 ! regulation of hemocyte differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0042386 ! positively regulates hemocyte differentiation relationship: RO:0002213 GO:0042386 ! positively regulates hemocyte differentiation [Term] id: GO:0045613 name: regulation of plasmatocyte differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of plasmatocyte differentiation." [GOC:go_curators] is_a: GO:0045610 ! regulation of hemocyte differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0042387 ! regulates plasmatocyte differentiation relationship: RO:0002211 GO:0042387 ! regulates plasmatocyte differentiation [Term] id: GO:0045614 name: negative regulation of plasmatocyte differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of plasmatocyte differentiation." [GOC:go_curators] synonym: "down regulation of plasmatocyte differentiation" EXACT [] synonym: "down-regulation of plasmatocyte differentiation" EXACT [] synonym: "downregulation of plasmatocyte differentiation" EXACT [] synonym: "inhibition of plasmatocyte differentiation" NARROW [] is_a: GO:0045611 ! negative regulation of hemocyte differentiation is_a: GO:0045613 ! regulation of plasmatocyte differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0042387 ! negatively regulates plasmatocyte differentiation relationship: RO:0002212 GO:0042387 ! negatively regulates plasmatocyte differentiation [Term] id: GO:0045615 name: positive regulation of plasmatocyte differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of plasmatocyte differentiation." [GOC:go_curators] synonym: "activation of plasmatocyte differentiation" NARROW [] synonym: "stimulation of plasmatocyte differentiation" NARROW [] synonym: "up regulation of plasmatocyte differentiation" EXACT [] synonym: "up-regulation of plasmatocyte differentiation" EXACT [] synonym: "upregulation of plasmatocyte differentiation" EXACT [] is_a: GO:0045612 ! positive regulation of hemocyte differentiation is_a: GO:0045613 ! regulation of plasmatocyte differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0042387 ! positively regulates plasmatocyte differentiation relationship: RO:0002213 GO:0042387 ! positively regulates plasmatocyte differentiation [Term] id: GO:0045616 name: regulation of keratinocyte differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of keratinocyte differentiation." [GOC:go_curators] xref: Reactome:R-HSA-8939242 "RUNX1 regulates transcription of genes involved in differentiation of keratinocytes" is_a: GO:0045604 ! regulation of epidermal cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0030216 ! regulates keratinocyte differentiation relationship: RO:0002211 GO:0030216 ! regulates keratinocyte differentiation [Term] id: GO:0045617 name: negative regulation of keratinocyte differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of keratinocyte differentiation." [GOC:go_curators] synonym: "down regulation of keratinocyte differentiation" EXACT [] synonym: "down-regulation of keratinocyte differentiation" EXACT [] synonym: "downregulation of keratinocyte differentiation" EXACT [] synonym: "inhibition of keratinocyte differentiation" NARROW [] is_a: GO:0045605 ! negative regulation of epidermal cell differentiation is_a: GO:0045616 ! regulation of keratinocyte differentiation is_a: GO:0051241 ! negative regulation of multicellular organismal process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0030216 ! negatively regulates keratinocyte differentiation relationship: RO:0002212 GO:0030216 ! negatively regulates keratinocyte differentiation [Term] id: GO:0045618 name: positive regulation of keratinocyte differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of keratinocyte differentiation." [GOC:go_curators] synonym: "activation of keratinocyte differentiation" NARROW [] synonym: "stimulation of keratinocyte differentiation" NARROW [] synonym: "up regulation of keratinocyte differentiation" EXACT [] synonym: "up-regulation of keratinocyte differentiation" EXACT [] synonym: "upregulation of keratinocyte differentiation" EXACT [] is_a: GO:0045606 ! positive regulation of epidermal cell differentiation is_a: GO:0045616 ! regulation of keratinocyte differentiation is_a: GO:0051240 ! positive regulation of multicellular organismal process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0030216 ! positively regulates keratinocyte differentiation relationship: RO:0002213 GO:0030216 ! positively regulates keratinocyte differentiation [Term] id: GO:0045619 name: regulation of lymphocyte differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of lymphocyte differentiation." [GOC:go_curators] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "regulation of lymphocyte development" RELATED [GOC:add] is_a: GO:0051249 ! regulation of lymphocyte activation is_a: GO:1902105 ! regulation of leukocyte differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0030098 ! regulates lymphocyte differentiation relationship: RO:0002211 GO:0030098 ! regulates lymphocyte differentiation [Term] id: GO:0045620 name: negative regulation of lymphocyte differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of lymphocyte differentiation." [GOC:go_curators] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "down regulation of lymphocyte differentiation" EXACT [] synonym: "down-regulation of lymphocyte differentiation" EXACT [] synonym: "downregulation of lymphocyte differentiation" EXACT [] synonym: "inhibition of lymphocyte differentiation" NARROW [] synonym: "negative regulation of lymphocyte development" RELATED [GOC:add] is_a: GO:0045619 ! regulation of lymphocyte differentiation is_a: GO:0051250 ! negative regulation of lymphocyte activation is_a: GO:1902106 ! negative regulation of leukocyte differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0030098 ! negatively regulates lymphocyte differentiation relationship: RO:0002212 GO:0030098 ! negatively regulates lymphocyte differentiation [Term] id: GO:0045621 name: positive regulation of lymphocyte differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of lymphocyte differentiation." [GOC:go_curators] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "activation of lymphocyte differentiation" NARROW [] synonym: "positive regulation of lymphocyte development" RELATED [GOC:add] synonym: "stimulation of lymphocyte differentiation" NARROW [] synonym: "up regulation of lymphocyte differentiation" EXACT [] synonym: "up-regulation of lymphocyte differentiation" EXACT [] synonym: "upregulation of lymphocyte differentiation" EXACT [] is_a: GO:0045619 ! regulation of lymphocyte differentiation is_a: GO:0051251 ! positive regulation of lymphocyte activation is_a: GO:1902107 ! positive regulation of leukocyte differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0030098 ! positively regulates lymphocyte differentiation relationship: RO:0002213 GO:0030098 ! positively regulates lymphocyte differentiation [Term] id: GO:0045622 name: regulation of T-helper cell differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of T-helper cell differentiation." [GOC:go_curators] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "regulation of T-helper cell development" RELATED [GOC:add] is_a: GO:0002697 ! regulation of immune effector process is_a: GO:0043370 ! regulation of CD4-positive, alpha-beta T cell differentiation is_a: GO:0050776 ! regulation of immune response intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0042093 ! regulates T-helper cell differentiation relationship: RO:0002211 GO:0042093 ! regulates T-helper cell differentiation [Term] id: GO:0045623 name: negative regulation of T-helper cell differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of T-helper cell differentiation." [GOC:go_curators] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "down regulation of T-helper cell differentiation" EXACT [] synonym: "down-regulation of T-helper cell differentiation" EXACT [] synonym: "downregulation of T-helper cell differentiation" EXACT [] synonym: "inhibition of T-helper cell differentiation" NARROW [] synonym: "negative regulation of T-helper cell development" RELATED [GOC:add] is_a: GO:0002698 ! negative regulation of immune effector process is_a: GO:0043371 ! negative regulation of CD4-positive, alpha-beta T cell differentiation is_a: GO:0045622 ! regulation of T-helper cell differentiation is_a: GO:0050777 ! negative regulation of immune response intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0042093 ! negatively regulates T-helper cell differentiation relationship: RO:0002212 GO:0042093 ! negatively regulates T-helper cell differentiation [Term] id: GO:0045624 name: positive regulation of T-helper cell differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of T-helper cell differentiation." [GOC:go_curators] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "activation of T-helper cell differentiation" NARROW [] synonym: "positive regulation of T-helper cell development" RELATED [GOC:add] synonym: "stimulation of T-helper cell differentiation" NARROW [] synonym: "up regulation of T-helper cell differentiation" EXACT [] synonym: "up-regulation of T-helper cell differentiation" EXACT [] synonym: "upregulation of T-helper cell differentiation" EXACT [] is_a: GO:0002699 ! positive regulation of immune effector process is_a: GO:0043372 ! positive regulation of CD4-positive, alpha-beta T cell differentiation is_a: GO:0045622 ! regulation of T-helper cell differentiation is_a: GO:0050778 ! positive regulation of immune response intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0042093 ! positively regulates T-helper cell differentiation relationship: RO:0002213 GO:0042093 ! positively regulates T-helper cell differentiation [Term] id: GO:0045625 name: regulation of T-helper 1 cell differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of T-helper 1 cell differentiation." [GOC:go_curators] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "regulation of T-helper 1 cell development" RELATED [GOC:add] is_a: GO:0002825 ! regulation of T-helper 1 type immune response is_a: GO:0045622 ! regulation of T-helper cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0045063 ! regulates T-helper 1 cell differentiation relationship: RO:0002211 GO:0045063 ! regulates T-helper 1 cell differentiation [Term] id: GO:0045626 name: negative regulation of T-helper 1 cell differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of T-helper 1 cell differentiation." [GOC:go_curators] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "down regulation of T-helper 1 cell differentiation" EXACT [] synonym: "down-regulation of T-helper 1 cell differentiation" EXACT [] synonym: "downregulation of T-helper 1 cell differentiation" EXACT [] synonym: "inhibition of T-helper 1 cell differentiation" NARROW [] synonym: "negative regulation of T-helper 1 cell development" RELATED [GOC:add] is_a: GO:0002826 ! negative regulation of T-helper 1 type immune response is_a: GO:0045623 ! negative regulation of T-helper cell differentiation is_a: GO:0045625 ! regulation of T-helper 1 cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0045063 ! negatively regulates T-helper 1 cell differentiation relationship: RO:0002212 GO:0045063 ! negatively regulates T-helper 1 cell differentiation [Term] id: GO:0045627 name: positive regulation of T-helper 1 cell differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of T-helper 1 cell differentiation." [GOC:go_curators] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "activation of T-helper 1 cell differentiation" NARROW [] synonym: "positive regulation of T-helper 1 cell development" RELATED [GOC:add] synonym: "stimulation of T-helper 1 cell differentiation" NARROW [] synonym: "up regulation of T-helper 1 cell differentiation" EXACT [] synonym: "up-regulation of T-helper 1 cell differentiation" EXACT [] synonym: "upregulation of T-helper 1 cell differentiation" EXACT [] is_a: GO:0045624 ! positive regulation of T-helper cell differentiation is_a: GO:0045625 ! regulation of T-helper 1 cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0045063 ! positively regulates T-helper 1 cell differentiation relationship: RO:0002213 GO:0045063 ! positively regulates T-helper 1 cell differentiation [Term] id: GO:0045628 name: regulation of T-helper 2 cell differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of T-helper 2 cell differentiation." [GOC:go_curators] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "regulation of T-helper 2 cell development" RELATED [GOC:add] is_a: GO:0002828 ! regulation of type 2 immune response is_a: GO:0045622 ! regulation of T-helper cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0045064 ! regulates T-helper 2 cell differentiation relationship: RO:0002211 GO:0045064 ! regulates T-helper 2 cell differentiation [Term] id: GO:0045629 name: negative regulation of T-helper 2 cell differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of T-helper 2 cell differentiation." [GOC:go_curators] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "down regulation of T-helper 2 cell differentiation" EXACT [] synonym: "down-regulation of T-helper 2 cell differentiation" EXACT [] synonym: "downregulation of T-helper 2 cell differentiation" EXACT [] synonym: "inhibition of T-helper 2 cell differentiation" NARROW [] synonym: "negative regulation of T-helper 2 cell development" RELATED [GOC:add] is_a: GO:0002829 ! negative regulation of type 2 immune response is_a: GO:0045623 ! negative regulation of T-helper cell differentiation is_a: GO:0045628 ! regulation of T-helper 2 cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0045064 ! negatively regulates T-helper 2 cell differentiation relationship: RO:0002212 GO:0045064 ! negatively regulates T-helper 2 cell differentiation [Term] id: GO:0045630 name: positive regulation of T-helper 2 cell differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of T-helper 2 cell differentiation." [GOC:go_curators] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "activation of T-helper 2 cell differentiation" NARROW [] synonym: "positive regulation of T-helper 2 cell development" RELATED [GOC:add] synonym: "stimulation of T-helper 2 cell differentiation" NARROW [] synonym: "up regulation of T-helper 2 cell differentiation" EXACT [] synonym: "up-regulation of T-helper 2 cell differentiation" EXACT [] synonym: "upregulation of T-helper 2 cell differentiation" EXACT [] is_a: GO:0002830 ! positive regulation of type 2 immune response is_a: GO:0045624 ! positive regulation of T-helper cell differentiation is_a: GO:0045628 ! regulation of T-helper 2 cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0045064 ! positively regulates T-helper 2 cell differentiation relationship: RO:0002213 GO:0045064 ! positively regulates T-helper 2 cell differentiation [Term] id: GO:0045631 name: regulation of mechanoreceptor differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of mechanoreceptor differentiation." [GOC:go_curators] is_a: GO:0045664 ! regulation of neuron differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0042490 ! regulates mechanoreceptor differentiation relationship: RO:0002211 GO:0042490 ! regulates mechanoreceptor differentiation [Term] id: GO:0045632 name: negative regulation of mechanoreceptor differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of mechanoreceptor differentiation." [GOC:go_curators] synonym: "down regulation of mechanoreceptor differentiation" EXACT [] synonym: "down-regulation of mechanoreceptor differentiation" EXACT [] synonym: "downregulation of mechanoreceptor differentiation" EXACT [] synonym: "inhibition of mechanoreceptor differentiation" NARROW [] is_a: GO:0045631 ! regulation of mechanoreceptor differentiation is_a: GO:0045665 ! negative regulation of neuron differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0042490 ! negatively regulates mechanoreceptor differentiation relationship: RO:0002212 GO:0042490 ! negatively regulates mechanoreceptor differentiation [Term] id: GO:0045633 name: positive regulation of mechanoreceptor differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of mechanoreceptor differentiation." [GOC:go_curators] synonym: "activation of mechanoreceptor differentiation" NARROW [] synonym: "stimulation of mechanoreceptor differentiation" NARROW [] synonym: "up regulation of mechanoreceptor differentiation" EXACT [] synonym: "up-regulation of mechanoreceptor differentiation" EXACT [] synonym: "upregulation of mechanoreceptor differentiation" EXACT [] is_a: GO:0045631 ! regulation of mechanoreceptor differentiation is_a: GO:0045666 ! positive regulation of neuron differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0042490 ! positively regulates mechanoreceptor differentiation relationship: RO:0002213 GO:0042490 ! positively regulates mechanoreceptor differentiation [Term] id: GO:0045634 name: regulation of melanocyte differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of melanocyte differentiation." [GOC:go_curators] synonym: "regulation of melanophore differentiation" EXACT [] is_a: GO:0050932 ! regulation of pigment cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0030318 ! regulates melanocyte differentiation relationship: RO:0002211 GO:0030318 ! regulates melanocyte differentiation [Term] id: GO:0045635 name: negative regulation of melanocyte differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of melanocyte differentiation." [GOC:go_curators] synonym: "down regulation of melanocyte differentiation" EXACT [] synonym: "down-regulation of melanocyte differentiation" EXACT [] synonym: "downregulation of melanocyte differentiation" EXACT [] synonym: "inhibition of melanocyte differentiation" NARROW [] synonym: "negative regulation of melanophore differentiation" EXACT [] is_a: GO:0045634 ! regulation of melanocyte differentiation is_a: GO:0050941 ! negative regulation of pigment cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0030318 ! negatively regulates melanocyte differentiation relationship: RO:0002212 GO:0030318 ! negatively regulates melanocyte differentiation [Term] id: GO:0045636 name: positive regulation of melanocyte differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of melanocyte differentiation." [GOC:go_curators] synonym: "activation of melanocyte differentiation" NARROW [] synonym: "positive regulation of melanophore differentiation" EXACT [] synonym: "stimulation of melanocyte differentiation" NARROW [] synonym: "up regulation of melanocyte differentiation" EXACT [] synonym: "up-regulation of melanocyte differentiation" EXACT [] synonym: "upregulation of melanocyte differentiation" EXACT [] is_a: GO:0045634 ! regulation of melanocyte differentiation is_a: GO:0050942 ! positive regulation of pigment cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0030318 ! positively regulates melanocyte differentiation relationship: RO:0002213 GO:0030318 ! positively regulates melanocyte differentiation [Term] id: GO:0045637 name: regulation of myeloid cell differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of myeloid cell differentiation." [GOC:go_curators] xref: Reactome:R-HSA-8939246 "RUNX1 regulates transcription of genes involved in differentiation of myeloid cells" is_a: GO:1903706 ! regulation of hemopoiesis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0030099 ! regulates myeloid cell differentiation relationship: RO:0002211 GO:0030099 ! regulates myeloid cell differentiation [Term] id: GO:0045638 name: negative regulation of myeloid cell differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of myeloid cell differentiation." [GOC:go_curators] synonym: "down regulation of myeloid cell differentiation" EXACT [] synonym: "down-regulation of myeloid cell differentiation" EXACT [] synonym: "downregulation of myeloid cell differentiation" EXACT [] synonym: "inhibition of myeloid cell differentiation" NARROW [] is_a: GO:0045596 ! negative regulation of cell differentiation is_a: GO:0045637 ! regulation of myeloid cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0030099 ! negatively regulates myeloid cell differentiation relationship: RO:0002212 GO:0030099 ! negatively regulates myeloid cell differentiation [Term] id: GO:0045639 name: positive regulation of myeloid cell differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of myeloid cell differentiation." [GOC:go_curators] synonym: "activation of myeloid cell differentiation" NARROW [] synonym: "stimulation of myeloid cell differentiation" NARROW [] synonym: "up regulation of myeloid cell differentiation" EXACT [] synonym: "up-regulation of myeloid cell differentiation" EXACT [] synonym: "upregulation of myeloid cell differentiation" EXACT [] is_a: GO:0045597 ! positive regulation of cell differentiation is_a: GO:0045637 ! regulation of myeloid cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0030099 ! positively regulates myeloid cell differentiation relationship: RO:0002213 GO:0030099 ! positively regulates myeloid cell differentiation [Term] id: GO:0045640 name: regulation of basophil differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of basophil differentiation." [GOC:go_curators] is_a: GO:0030852 ! regulation of granulocyte differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0030221 ! regulates basophil differentiation relationship: RO:0002211 GO:0030221 ! regulates basophil differentiation [Term] id: GO:0045641 name: negative regulation of basophil differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of basophil differentiation." [GOC:go_curators] synonym: "down regulation of basophil differentiation" EXACT [] synonym: "down-regulation of basophil differentiation" EXACT [] synonym: "downregulation of basophil differentiation" EXACT [] synonym: "inhibition of basophil differentiation" NARROW [] is_a: GO:0030853 ! negative regulation of granulocyte differentiation is_a: GO:0045640 ! regulation of basophil differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0030221 ! negatively regulates basophil differentiation relationship: RO:0002212 GO:0030221 ! negatively regulates basophil differentiation [Term] id: GO:0045642 name: positive regulation of basophil differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of basophil differentiation." [GOC:go_curators] synonym: "activation of basophil differentiation" NARROW [] synonym: "stimulation of basophil differentiation" NARROW [] synonym: "up regulation of basophil differentiation" EXACT [] synonym: "up-regulation of basophil differentiation" EXACT [] synonym: "upregulation of basophil differentiation" EXACT [] is_a: GO:0030854 ! positive regulation of granulocyte differentiation is_a: GO:0045640 ! regulation of basophil differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0030221 ! positively regulates basophil differentiation relationship: RO:0002213 GO:0030221 ! positively regulates basophil differentiation [Term] id: GO:0045643 name: regulation of eosinophil differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of eosinophil differentiation." [GOC:go_curators] is_a: GO:0030852 ! regulation of granulocyte differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0030222 ! regulates eosinophil differentiation relationship: RO:0002211 GO:0030222 ! regulates eosinophil differentiation [Term] id: GO:0045644 name: negative regulation of eosinophil differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of eosinophil differentiation." [GOC:go_curators] synonym: "down regulation of eosinophil differentiation" EXACT [] synonym: "down-regulation of eosinophil differentiation" EXACT [] synonym: "downregulation of eosinophil differentiation" EXACT [] synonym: "inhibition of eosinophil differentiation" NARROW [] is_a: GO:0030853 ! negative regulation of granulocyte differentiation is_a: GO:0045643 ! regulation of eosinophil differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0030222 ! negatively regulates eosinophil differentiation relationship: RO:0002212 GO:0030222 ! negatively regulates eosinophil differentiation [Term] id: GO:0045645 name: positive regulation of eosinophil differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of eosinophil differentiation." [GOC:go_curators] synonym: "activation of eosinophil differentiation" NARROW [] synonym: "stimulation of eosinophil differentiation" NARROW [] synonym: "up regulation of eosinophil differentiation" EXACT [] synonym: "up-regulation of eosinophil differentiation" EXACT [] synonym: "upregulation of eosinophil differentiation" EXACT [] is_a: GO:0030854 ! positive regulation of granulocyte differentiation is_a: GO:0045643 ! regulation of eosinophil differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0030222 ! positively regulates eosinophil differentiation relationship: RO:0002213 GO:0030222 ! positively regulates eosinophil differentiation [Term] id: GO:0045646 name: regulation of erythrocyte differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of erythrocyte differentiation." [GOC:go_curators] synonym: "regulation of RBC differentiation" EXACT [CL:0000232] synonym: "regulation of red blood cell differentiation" EXACT [CL:0000232] is_a: GO:0045637 ! regulation of myeloid cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0030218 ! regulates erythrocyte differentiation relationship: RO:0002211 GO:0030218 ! regulates erythrocyte differentiation [Term] id: GO:0045647 name: negative regulation of erythrocyte differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of erythrocyte differentiation." [GOC:go_curators] synonym: "down regulation of erythrocyte differentiation" EXACT [] synonym: "down-regulation of erythrocyte differentiation" EXACT [] synonym: "downregulation of erythrocyte differentiation" EXACT [] synonym: "inhibition of erythrocyte differentiation" NARROW [] synonym: "negative regulation of RBC differentiation" EXACT [CL:0000232] synonym: "negative regulation of red blood cell differentiation" EXACT [CL:0000232] is_a: GO:0045638 ! negative regulation of myeloid cell differentiation is_a: GO:0045646 ! regulation of erythrocyte differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0030218 ! negatively regulates erythrocyte differentiation relationship: RO:0002212 GO:0030218 ! negatively regulates erythrocyte differentiation [Term] id: GO:0045648 name: positive regulation of erythrocyte differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of erythrocyte differentiation." [GOC:go_curators] synonym: "activation of erythrocyte differentiation" NARROW [] synonym: "positive regulation of RBC differentiation" EXACT [CL:0000232] synonym: "positive regulation of red blood cell differentiation" EXACT [CL:0000232] synonym: "stimulation of erythrocyte differentiation" NARROW [] synonym: "up regulation of erythrocyte differentiation" EXACT [] synonym: "up-regulation of erythrocyte differentiation" EXACT [] synonym: "upregulation of erythrocyte differentiation" EXACT [] is_a: GO:0045639 ! positive regulation of myeloid cell differentiation is_a: GO:0045646 ! regulation of erythrocyte differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0030218 ! positively regulates erythrocyte differentiation relationship: RO:0002213 GO:0030218 ! positively regulates erythrocyte differentiation [Term] id: GO:0045649 name: regulation of macrophage differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of macrophage differentiation." [GOC:go_curators] is_a: GO:0002761 ! regulation of myeloid leukocyte differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0030225 ! regulates macrophage differentiation relationship: RO:0002211 GO:0030225 ! regulates macrophage differentiation [Term] id: GO:0045650 name: negative regulation of macrophage differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of macrophage differentiation." [GOC:go_curators] synonym: "down regulation of macrophage differentiation" EXACT [] synonym: "down-regulation of macrophage differentiation" EXACT [] synonym: "downregulation of macrophage differentiation" EXACT [] synonym: "inhibition of macrophage differentiation" NARROW [] is_a: GO:0002762 ! negative regulation of myeloid leukocyte differentiation is_a: GO:0045649 ! regulation of macrophage differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0030225 ! negatively regulates macrophage differentiation relationship: RO:0002212 GO:0030225 ! negatively regulates macrophage differentiation [Term] id: GO:0045651 name: positive regulation of macrophage differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of macrophage differentiation." [GOC:go_curators] synonym: "activation of macrophage differentiation" NARROW [] synonym: "stimulation of macrophage differentiation" NARROW [] synonym: "up regulation of macrophage differentiation" EXACT [] synonym: "up-regulation of macrophage differentiation" EXACT [] synonym: "upregulation of macrophage differentiation" EXACT [] is_a: GO:0002763 ! positive regulation of myeloid leukocyte differentiation is_a: GO:0045649 ! regulation of macrophage differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0030225 ! positively regulates macrophage differentiation relationship: RO:0002213 GO:0030225 ! positively regulates macrophage differentiation [Term] id: GO:0045652 name: regulation of megakaryocyte differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of megakaryocyte differentiation." [GOC:go_curators] xref: Reactome:R-HSA-8936459 "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function" is_a: GO:0045637 ! regulation of myeloid cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0030219 ! regulates megakaryocyte differentiation relationship: RO:0002211 GO:0030219 ! regulates megakaryocyte differentiation [Term] id: GO:0045653 name: negative regulation of megakaryocyte differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of megakaryocyte differentiation." [GOC:go_curators] synonym: "down regulation of megakaryocyte differentiation" EXACT [] synonym: "down-regulation of megakaryocyte differentiation" EXACT [] synonym: "downregulation of megakaryocyte differentiation" EXACT [] synonym: "inhibition of megakaryocyte differentiation" NARROW [] is_a: GO:0045638 ! negative regulation of myeloid cell differentiation is_a: GO:0045652 ! regulation of megakaryocyte differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0030219 ! negatively regulates megakaryocyte differentiation relationship: RO:0002212 GO:0030219 ! negatively regulates megakaryocyte differentiation [Term] id: GO:0045654 name: positive regulation of megakaryocyte differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of megakaryocyte differentiation." [GOC:go_curators] synonym: "activation of megakaryocyte differentiation" NARROW [] synonym: "stimulation of megakaryocyte differentiation" NARROW [] synonym: "up regulation of megakaryocyte differentiation" EXACT [] synonym: "up-regulation of megakaryocyte differentiation" EXACT [] synonym: "upregulation of megakaryocyte differentiation" EXACT [] is_a: GO:0045639 ! positive regulation of myeloid cell differentiation is_a: GO:0045652 ! regulation of megakaryocyte differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0030219 ! positively regulates megakaryocyte differentiation relationship: RO:0002213 GO:0030219 ! positively regulates megakaryocyte differentiation [Term] id: GO:0045655 name: regulation of monocyte differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of monocyte differentiation." [GOC:go_curators] is_a: GO:0002761 ! regulation of myeloid leukocyte differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0030224 ! regulates monocyte differentiation relationship: RO:0002211 GO:0030224 ! regulates monocyte differentiation [Term] id: GO:0045656 name: negative regulation of monocyte differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of monocyte differentiation." [GOC:go_curators] synonym: "down regulation of monocyte differentiation" EXACT [] synonym: "down-regulation of monocyte differentiation" EXACT [] synonym: "downregulation of monocyte differentiation" EXACT [] synonym: "inhibition of monocyte differentiation" NARROW [] is_a: GO:0002762 ! negative regulation of myeloid leukocyte differentiation is_a: GO:0045655 ! regulation of monocyte differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0030224 ! negatively regulates monocyte differentiation relationship: RO:0002212 GO:0030224 ! negatively regulates monocyte differentiation [Term] id: GO:0045657 name: positive regulation of monocyte differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of monocyte differentiation." [GOC:go_curators] synonym: "activation of monocyte differentiation" NARROW [] synonym: "stimulation of monocyte differentiation" NARROW [] synonym: "up regulation of monocyte differentiation" EXACT [] synonym: "up-regulation of monocyte differentiation" EXACT [] synonym: "upregulation of monocyte differentiation" EXACT [] is_a: GO:0002763 ! positive regulation of myeloid leukocyte differentiation is_a: GO:0045655 ! regulation of monocyte differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0030224 ! positively regulates monocyte differentiation relationship: RO:0002213 GO:0030224 ! positively regulates monocyte differentiation [Term] id: GO:0045658 name: regulation of neutrophil differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of neutrophil differentiation." [GOC:go_curators] is_a: GO:0030852 ! regulation of granulocyte differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0030223 ! regulates neutrophil differentiation relationship: RO:0002211 GO:0030223 ! regulates neutrophil differentiation [Term] id: GO:0045659 name: negative regulation of neutrophil differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of neutrophil differentiation." [GOC:go_curators] synonym: "down regulation of neutrophil differentiation" EXACT [] synonym: "down-regulation of neutrophil differentiation" EXACT [] synonym: "downregulation of neutrophil differentiation" EXACT [] synonym: "inhibition of neutrophil differentiation" NARROW [] is_a: GO:0030853 ! negative regulation of granulocyte differentiation is_a: GO:0045658 ! regulation of neutrophil differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0030223 ! negatively regulates neutrophil differentiation relationship: RO:0002212 GO:0030223 ! negatively regulates neutrophil differentiation [Term] id: GO:0045660 name: positive regulation of neutrophil differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of neutrophil differentiation." [GOC:go_curators] synonym: "activation of neutrophil differentiation" NARROW [] synonym: "stimulation of neutrophil differentiation" NARROW [] synonym: "up regulation of neutrophil differentiation" EXACT [] synonym: "up-regulation of neutrophil differentiation" EXACT [] synonym: "upregulation of neutrophil differentiation" EXACT [] is_a: GO:0030854 ! positive regulation of granulocyte differentiation is_a: GO:0045658 ! regulation of neutrophil differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0030223 ! positively regulates neutrophil differentiation relationship: RO:0002213 GO:0030223 ! positively regulates neutrophil differentiation [Term] id: GO:0045661 name: regulation of myoblast differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of myoblast differentiation. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers." [CL:0000056, GOC:go_curators, GOC:mtg_muscle] is_a: GO:0045595 ! regulation of cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0045445 ! regulates myoblast differentiation relationship: RO:0002211 GO:0045445 ! regulates myoblast differentiation [Term] id: GO:0045662 name: negative regulation of myoblast differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of myoblast differentiation. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers." [CL:0000056, GOC:go_curators, GOC:mtg_muscle] synonym: "down regulation of myoblast differentiation" EXACT [] synonym: "down-regulation of myoblast differentiation" EXACT [] synonym: "downregulation of myoblast differentiation" EXACT [] synonym: "inhibition of myoblast differentiation" NARROW [] is_a: GO:0045596 ! negative regulation of cell differentiation is_a: GO:0045661 ! regulation of myoblast differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0045445 ! negatively regulates myoblast differentiation relationship: RO:0002212 GO:0045445 ! negatively regulates myoblast differentiation [Term] id: GO:0045663 name: positive regulation of myoblast differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of myoblast differentiation. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers." [CL:0000056, GOC:go_curators, GOC:mtg_muscle] synonym: "activation of myoblast differentiation" NARROW [] synonym: "stimulation of myoblast differentiation" NARROW [] synonym: "up regulation of myoblast differentiation" EXACT [] synonym: "up-regulation of myoblast differentiation" EXACT [] synonym: "upregulation of myoblast differentiation" EXACT [] is_a: GO:0045597 ! positive regulation of cell differentiation is_a: GO:0045661 ! regulation of myoblast differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0045445 ! positively regulates myoblast differentiation relationship: RO:0002213 GO:0045445 ! positively regulates myoblast differentiation [Term] id: GO:0045664 name: regulation of neuron differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of neuron differentiation." [GOC:go_curators] is_a: GO:0045595 ! regulation of cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0030182 ! regulates neuron differentiation relationship: RO:0002211 GO:0030182 ! regulates neuron differentiation [Term] id: GO:0045665 name: negative regulation of neuron differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of neuron differentiation." [GOC:go_curators] synonym: "down regulation of neuron differentiation" EXACT [] synonym: "down-regulation of neuron differentiation" EXACT [] synonym: "downregulation of neuron differentiation" EXACT [] synonym: "inhibition of neuron differentiation" NARROW [] is_a: GO:0045596 ! negative regulation of cell differentiation is_a: GO:0045664 ! regulation of neuron differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0030182 ! negatively regulates neuron differentiation relationship: RO:0002212 GO:0030182 ! negatively regulates neuron differentiation [Term] id: GO:0045666 name: positive regulation of neuron differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of neuron differentiation." [GOC:go_curators] synonym: "activation of neuron differentiation" NARROW [] synonym: "stimulation of neuron differentiation" NARROW [] synonym: "up regulation of neuron differentiation" EXACT [] synonym: "up-regulation of neuron differentiation" EXACT [] synonym: "upregulation of neuron differentiation" EXACT [] is_a: GO:0045597 ! positive regulation of cell differentiation is_a: GO:0045664 ! regulation of neuron differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0030182 ! positively regulates neuron differentiation relationship: RO:0002213 GO:0030182 ! positively regulates neuron differentiation [Term] id: GO:0045667 name: regulation of osteoblast differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of osteoblast differentiation." [GOC:go_curators] is_a: GO:0045595 ! regulation of cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0001649 ! regulates osteoblast differentiation relationship: RO:0002211 GO:0001649 ! regulates osteoblast differentiation [Term] id: GO:0045668 name: negative regulation of osteoblast differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of osteoblast differentiation." [GOC:go_curators] synonym: "down regulation of osteoblast differentiation" EXACT [] synonym: "down-regulation of osteoblast differentiation" EXACT [] synonym: "downregulation of osteoblast differentiation" EXACT [] synonym: "inhibition of osteoblast differentiation" NARROW [] is_a: GO:0045596 ! negative regulation of cell differentiation is_a: GO:0045667 ! regulation of osteoblast differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0001649 ! negatively regulates osteoblast differentiation relationship: RO:0002212 GO:0001649 ! negatively regulates osteoblast differentiation [Term] id: GO:0045669 name: positive regulation of osteoblast differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of osteoblast differentiation." [GOC:go_curators] synonym: "activation of osteoblast differentiation" NARROW [] synonym: "stimulation of osteoblast differentiation" NARROW [] synonym: "up regulation of osteoblast differentiation" EXACT [] synonym: "up-regulation of osteoblast differentiation" EXACT [] synonym: "upregulation of osteoblast differentiation" EXACT [] is_a: GO:0045597 ! positive regulation of cell differentiation is_a: GO:0045667 ! regulation of osteoblast differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0001649 ! positively regulates osteoblast differentiation relationship: RO:0002213 GO:0001649 ! positively regulates osteoblast differentiation [Term] id: GO:0045670 name: regulation of osteoclast differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of osteoclast differentiation." [GOC:go_curators] is_a: GO:0002761 ! regulation of myeloid leukocyte differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0030316 ! regulates osteoclast differentiation relationship: RO:0002211 GO:0030316 ! regulates osteoclast differentiation [Term] id: GO:0045671 name: negative regulation of osteoclast differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of osteoclast differentiation." [GOC:go_curators] synonym: "down regulation of osteoclast differentiation" EXACT [] synonym: "down-regulation of osteoclast differentiation" EXACT [] synonym: "downregulation of osteoclast differentiation" EXACT [] synonym: "inhibition of osteoclast differentiation" NARROW [] is_a: GO:0002762 ! negative regulation of myeloid leukocyte differentiation is_a: GO:0045670 ! regulation of osteoclast differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0030316 ! negatively regulates osteoclast differentiation relationship: RO:0002212 GO:0030316 ! negatively regulates osteoclast differentiation [Term] id: GO:0045672 name: positive regulation of osteoclast differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of osteoclast differentiation." [GOC:go_curators] synonym: "activation of osteoclast differentiation" NARROW [] synonym: "stimulation of osteoclast differentiation" NARROW [] synonym: "up regulation of osteoclast differentiation" EXACT [] synonym: "up-regulation of osteoclast differentiation" EXACT [] synonym: "upregulation of osteoclast differentiation" EXACT [] is_a: GO:0002763 ! positive regulation of myeloid leukocyte differentiation is_a: GO:0045670 ! regulation of osteoclast differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0030316 ! positively regulates osteoclast differentiation relationship: RO:0002213 GO:0030316 ! positively regulates osteoclast differentiation [Term] id: GO:0045676 name: regulation of R7 cell differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of R7 differentiation." [GOC:go_curators] is_a: GO:0110116 ! regulation of compound eye photoreceptor cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0045466 ! regulates R7 cell differentiation relationship: RO:0002211 GO:0045466 ! regulates R7 cell differentiation [Term] id: GO:0045677 name: negative regulation of R7 cell differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of R7cell differentiation." [GOC:dph, GOC:go_curators, GOC:tb] synonym: "down regulation of R7 differentiation" EXACT [] synonym: "down-regulation of R7 differentiation" EXACT [] synonym: "downregulation of R7 differentiation" EXACT [] synonym: "inhibition of R7 differentiation" NARROW [] synonym: "negative regulation of R7 differentiation" EXACT [GOC:dph, GOC:tb] is_a: GO:0045676 ! regulation of R7 cell differentiation is_a: GO:0110118 ! negative regulation of compound eye photoreceptor cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0045466 ! negatively regulates R7 cell differentiation relationship: RO:0002212 GO:0045466 ! negatively regulates R7 cell differentiation [Term] id: GO:0045678 name: positive regulation of R7 cell differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of R7 cell differentiation." [GOC:dph, GOC:go_curators, GOC:tb] synonym: "activation of R7 differentiation" NARROW [] synonym: "positive regulation of R7 differentiation" EXACT [GOC:dph, GOC:tb] synonym: "stimulation of R7 differentiation" NARROW [] synonym: "up regulation of R7 differentiation" EXACT [] synonym: "up-regulation of R7 differentiation" EXACT [] synonym: "upregulation of R7 differentiation" EXACT [] is_a: GO:0045676 ! regulation of R7 cell differentiation is_a: GO:0110117 ! positive regulation of compound eye photoreceptor cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0045466 ! positively regulates R7 cell differentiation relationship: RO:0002213 GO:0045466 ! positively regulates R7 cell differentiation [Term] id: GO:0045679 name: regulation of R8 cell differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of R8 differentiation." [GOC:go_curators] is_a: GO:0110116 ! regulation of compound eye photoreceptor cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0045465 ! regulates R8 cell differentiation relationship: RO:0002211 GO:0045465 ! regulates R8 cell differentiation [Term] id: GO:0045680 name: negative regulation of R8 cell differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of R8 cell differentiation." [GOC:dph, GOC:go_curators, GOC:tb] synonym: "down regulation of R8 differentiation" EXACT [] synonym: "down-regulation of R8 differentiation" EXACT [] synonym: "downregulation of R8 differentiation" EXACT [] synonym: "inhibition of R8 differentiation" NARROW [] synonym: "negative regulation of R8 differentiation" EXACT [GOC:dph, GOC:tb] is_a: GO:0045679 ! regulation of R8 cell differentiation is_a: GO:0110118 ! negative regulation of compound eye photoreceptor cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0045465 ! negatively regulates R8 cell differentiation relationship: RO:0002212 GO:0045465 ! negatively regulates R8 cell differentiation [Term] id: GO:0045681 name: positive regulation of R8 cell differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of R8 cell differentiation." [GOC:dph, GOC:go_curators, GOC:tb] synonym: "activation of R8 differentiation" NARROW [] synonym: "positive regulation of R8 differentiation" EXACT [GOC:dph, GOC:tb] synonym: "stimulation of R8 differentiation" NARROW [] synonym: "up regulation of R8 differentiation" EXACT [] synonym: "up-regulation of R8 differentiation" EXACT [] synonym: "upregulation of R8 differentiation" EXACT [] is_a: GO:0045679 ! regulation of R8 cell differentiation is_a: GO:0110117 ! positive regulation of compound eye photoreceptor cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0045465 ! positively regulates R8 cell differentiation relationship: RO:0002213 GO:0045465 ! positively regulates R8 cell differentiation [Term] id: GO:0045682 name: regulation of epidermis development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of epidermis development." [GOC:go_curators] synonym: "regulation of epidermal development" EXACT [] synonym: "regulation of hypodermis development" RELATED [GOC:kmv, GOC:rk] is_a: GO:0050793 ! regulation of developmental process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0008544 ! regulates epidermis development relationship: RO:0002211 GO:0008544 ! regulates epidermis development property_value: RO:0002161 NCBITaxon:147554 property_value: RO:0002161 NCBITaxon:33090 property_value: RO:0002161 NCBITaxon:33630 property_value: RO:0002161 NCBITaxon:33682 property_value: RO:0002161 NCBITaxon:38254 property_value: RO:0002161 NCBITaxon:4891 [Term] id: GO:0045683 name: negative regulation of epidermis development namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of epidermis development." [GOC:go_curators] synonym: "down regulation of epidermis development" EXACT [] synonym: "down-regulation of epidermis development" EXACT [] synonym: "downregulation of epidermis development" EXACT [] synonym: "inhibition of epidermis development" NARROW [] synonym: "negative regulation of epidermal development" EXACT [] synonym: "negative regulation of hypodermis development" RELATED [GOC:kmv, GOC:rk] is_a: GO:0045682 ! regulation of epidermis development is_a: GO:0051093 ! negative regulation of developmental process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0008544 ! negatively regulates epidermis development relationship: RO:0002212 GO:0008544 ! negatively regulates epidermis development property_value: RO:0002161 NCBITaxon:147554 property_value: RO:0002161 NCBITaxon:33090 property_value: RO:0002161 NCBITaxon:33630 property_value: RO:0002161 NCBITaxon:33682 property_value: RO:0002161 NCBITaxon:38254 property_value: RO:0002161 NCBITaxon:4891 [Term] id: GO:0045684 name: positive regulation of epidermis development namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of epidermis development." [GOC:go_curators] synonym: "activation of epidermis development" NARROW [] synonym: "positive regulation of epidermal development" EXACT [] synonym: "positive regulation of hypodermis development" RELATED [GOC:kmv, GOC:rk] synonym: "stimulation of epidermis development" NARROW [] synonym: "up regulation of epidermis development" EXACT [] synonym: "up-regulation of epidermis development" EXACT [] synonym: "upregulation of epidermis development" EXACT [] is_a: GO:0045682 ! regulation of epidermis development is_a: GO:0051094 ! positive regulation of developmental process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0008544 ! positively regulates epidermis development relationship: RO:0002213 GO:0008544 ! positively regulates epidermis development property_value: RO:0002161 NCBITaxon:147554 property_value: RO:0002161 NCBITaxon:33090 property_value: RO:0002161 NCBITaxon:33630 property_value: RO:0002161 NCBITaxon:33682 property_value: RO:0002161 NCBITaxon:38254 property_value: RO:0002161 NCBITaxon:4891 [Term] id: GO:0045685 name: regulation of glial cell differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of glia cell differentiation." [GOC:go_curators] synonym: "regulation of glia cell differentiation" EXACT [] synonym: "regulation of neuroglia differentiation" EXACT [] is_a: GO:0045595 ! regulation of cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0010001 ! regulates glial cell differentiation relationship: RO:0002211 GO:0010001 ! regulates glial cell differentiation [Term] id: GO:0045686 name: negative regulation of glial cell differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of glia cell differentiation." [GOC:go_curators] synonym: "down regulation of glial cell differentiation" EXACT [] synonym: "down-regulation of glial cell differentiation" EXACT [] synonym: "downregulation of glial cell differentiation" EXACT [] synonym: "inhibition of glial cell differentiation" NARROW [] synonym: "negative regulation of glia cell differentiation" EXACT [] synonym: "negative regulation of neuroglia differentiation" EXACT [] is_a: GO:0014014 ! negative regulation of gliogenesis is_a: GO:0045685 ! regulation of glial cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0010001 ! negatively regulates glial cell differentiation relationship: RO:0002212 GO:0010001 ! negatively regulates glial cell differentiation [Term] id: GO:0045687 name: positive regulation of glial cell differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of glia cell differentiation." [GOC:go_curators] synonym: "activation of glial cell differentiation" NARROW [] synonym: "positive regulation of glia cell differentiation" EXACT [] synonym: "positive regulation of neuroglia differentiation" EXACT [] synonym: "stimulation of glial cell differentiation" NARROW [] synonym: "up regulation of glial cell differentiation" EXACT [] synonym: "up-regulation of glial cell differentiation" EXACT [] synonym: "upregulation of glial cell differentiation" EXACT [] is_a: GO:0014015 ! positive regulation of gliogenesis is_a: GO:0045685 ! regulation of glial cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0010001 ! positively regulates glial cell differentiation relationship: RO:0002213 GO:0010001 ! positively regulates glial cell differentiation [Term] id: GO:0045700 name: regulation of spermatid nuclear differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of spermatid nuclear differentiation." [GOC:go_curators] is_a: GO:0051239 ! regulation of multicellular organismal process is_a: GO:1903353 ! regulation of nucleus organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0007289 ! regulates spermatid nucleus differentiation relationship: RO:0002211 GO:0007289 ! regulates spermatid nucleus differentiation property_value: RO:0002161 NCBITaxon:3176 property_value: RO:0002161 NCBITaxon:3378 property_value: RO:0002161 NCBITaxon:3398 property_value: RO:0002161 NCBITaxon:4751 property_value: RO:0002161 NCBITaxon:5782 [Term] id: GO:0045701 name: negative regulation of spermatid nuclear differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of spermatid nuclear differentiation." [GOC:go_curators] synonym: "down regulation of spermatid nuclear differentiation" EXACT [] synonym: "down-regulation of spermatid nuclear differentiation" EXACT [] synonym: "downregulation of spermatid nuclear differentiation" EXACT [] synonym: "inhibition of spermatid nuclear differentiation" NARROW [] is_a: GO:0010639 ! negative regulation of organelle organization is_a: GO:0045596 ! negative regulation of cell differentiation is_a: GO:0045700 ! regulation of spermatid nuclear differentiation is_a: GO:0051241 ! negative regulation of multicellular organismal process is_a: GO:2000242 ! negative regulation of reproductive process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0007289 ! negatively regulates spermatid nucleus differentiation relationship: RO:0002212 GO:0007289 ! negatively regulates spermatid nucleus differentiation property_value: RO:0002161 NCBITaxon:3176 property_value: RO:0002161 NCBITaxon:3378 property_value: RO:0002161 NCBITaxon:3398 property_value: RO:0002161 NCBITaxon:4751 property_value: RO:0002161 NCBITaxon:5782 [Term] id: GO:0045702 name: positive regulation of spermatid nuclear differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of spermatid nuclear differentiation." [GOC:go_curators] synonym: "activation of spermatid nuclear differentiation" NARROW [] synonym: "stimulation of spermatid nuclear differentiation" NARROW [] synonym: "up regulation of spermatid nuclear differentiation" EXACT [] synonym: "up-regulation of spermatid nuclear differentiation" EXACT [] synonym: "upregulation of spermatid nuclear differentiation" EXACT [] is_a: GO:0010638 ! positive regulation of organelle organization is_a: GO:0045597 ! positive regulation of cell differentiation is_a: GO:0045700 ! regulation of spermatid nuclear differentiation is_a: GO:2000243 ! positive regulation of reproductive process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0007289 ! positively regulates spermatid nucleus differentiation relationship: RO:0002213 GO:0007289 ! positively regulates spermatid nucleus differentiation property_value: RO:0002161 NCBITaxon:3176 property_value: RO:0002161 NCBITaxon:3378 property_value: RO:0002161 NCBITaxon:3398 property_value: RO:0002161 NCBITaxon:4751 property_value: RO:0002161 NCBITaxon:5782 [Term] id: GO:0045717 name: negative regulation of fatty acid biosynthetic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of fatty acids." [GOC:go_curators] synonym: "down regulation of fatty acid biosynthetic process" EXACT [] synonym: "down-regulation of fatty acid biosynthetic process" EXACT [] synonym: "downregulation of fatty acid biosynthetic process" EXACT [] synonym: "inhibition of fatty acid biosynthetic process" NARROW [] synonym: "negative regulation of fatty acid anabolism" EXACT [] synonym: "negative regulation of fatty acid biosynthesis" EXACT [] synonym: "negative regulation of fatty acid formation" EXACT [] synonym: "negative regulation of fatty acid synthesis" EXACT [] is_a: GO:0042304 ! regulation of fatty acid biosynthetic process is_a: GO:0045922 ! negative regulation of fatty acid metabolic process is_a: GO:0051055 ! negative regulation of lipid biosynthetic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0006633 ! negatively regulates fatty acid biosynthetic process relationship: RO:0002212 GO:0006633 ! negatively regulates fatty acid biosynthetic process [Term] id: GO:0045719 name: negative regulation of glycogen biosynthetic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of glycogen." [GOC:go_curators] synonym: "down regulation of glycogen biosynthetic process" EXACT [] synonym: "down-regulation of glycogen biosynthetic process" EXACT [] synonym: "downregulation of glycogen biosynthetic process" EXACT [] synonym: "inhibition of glycogen biosynthetic process" NARROW [] synonym: "negative regulation of glycogen anabolism" EXACT [] synonym: "negative regulation of glycogen biosynthesis" EXACT [] synonym: "negative regulation of glycogen formation" EXACT [] synonym: "negative regulation of glycogen synthesis" EXACT [] is_a: GO:0005979 ! regulation of glycogen biosynthetic process is_a: GO:0010558 ! negative regulation of macromolecule biosynthetic process is_a: GO:0070874 ! negative regulation of glycogen metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0005978 ! negatively regulates glycogen biosynthetic process relationship: RO:0002212 GO:0005978 ! negatively regulates glycogen biosynthetic process [Term] id: GO:0045721 name: negative regulation of gluconeogenesis namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of gluconeogenesis." [GOC:go_curators] synonym: "down regulation of gluconeogenesis" EXACT [] synonym: "down-regulation of gluconeogenesis" EXACT [] synonym: "downregulation of gluconeogenesis" EXACT [] synonym: "inhibition of gluconeogenesis" NARROW [] is_a: GO:0006111 ! regulation of gluconeogenesis is_a: GO:0009890 ! negative regulation of biosynthetic process is_a: GO:0045912 ! negative regulation of carbohydrate metabolic process is_a: GO:0062014 ! negative regulation of small molecule metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0006094 ! negatively regulates gluconeogenesis relationship: RO:0002212 GO:0006094 ! negatively regulates gluconeogenesis [Term] id: GO:0045722 name: positive regulation of gluconeogenesis namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of gluconeogenesis." [GOC:go_curators] synonym: "activation of gluconeogenesis" NARROW [] synonym: "stimulation of gluconeogenesis" NARROW [] synonym: "up regulation of gluconeogenesis" EXACT [] synonym: "up-regulation of gluconeogenesis" EXACT [] synonym: "upregulation of gluconeogenesis" EXACT [] is_a: GO:0006111 ! regulation of gluconeogenesis is_a: GO:0009891 ! positive regulation of biosynthetic process is_a: GO:0010907 ! positive regulation of glucose metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0006094 ! positively regulates gluconeogenesis relationship: RO:0002213 GO:0006094 ! positively regulates gluconeogenesis [Term] id: GO:0045723 name: positive regulation of fatty acid biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of fatty acids." [GOC:go_curators] synonym: "activation of fatty acid biosynthetic process" NARROW [] synonym: "positive regulation of fatty acid anabolism" EXACT [] synonym: "positive regulation of fatty acid biosynthesis" EXACT [] synonym: "positive regulation of fatty acid formation" EXACT [] synonym: "positive regulation of fatty acid synthesis" EXACT [] synonym: "stimulation of fatty acid biosynthetic process" NARROW [] synonym: "up regulation of fatty acid biosynthetic process" EXACT [] synonym: "up-regulation of fatty acid biosynthetic process" EXACT [] synonym: "upregulation of fatty acid biosynthetic process" EXACT [] is_a: GO:0042304 ! regulation of fatty acid biosynthetic process is_a: GO:0045923 ! positive regulation of fatty acid metabolic process is_a: GO:0046889 ! positive regulation of lipid biosynthetic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0006633 ! positively regulates fatty acid biosynthetic process relationship: RO:0002213 GO:0006633 ! positively regulates fatty acid biosynthetic process [Term] id: GO:0045724 name: positive regulation of cilium assembly namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the formation of a cilium." [GOC:cilia, GOC:go_curators] synonym: "activation of cilium assembly" NARROW [] synonym: "positive regulation of flagellum assembly" BROAD [] synonym: "positive regulation of flagellum biogenesis" RELATED [GOC:mah] synonym: "stimulation of cilium assembly" NARROW [] synonym: "up regulation of cilium assembly" EXACT [] synonym: "up-regulation of cilium assembly" EXACT [] synonym: "upregulation of cilium assembly" EXACT [] is_a: GO:0120034 ! positive regulation of plasma membrane bounded cell projection assembly is_a: GO:1902017 ! regulation of cilium assembly is_a: GO:1902117 ! positive regulation of organelle assembly intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0060271 ! positively regulates cilium assembly relationship: RO:0002213 GO:0060271 ! positively regulates cilium assembly property_value: RO:0002161 NCBITaxon:3176 property_value: RO:0002161 NCBITaxon:3378 property_value: RO:0002161 NCBITaxon:3398 property_value: RO:0002161 NCBITaxon:4751 property_value: RO:0002161 NCBITaxon:5782 [Term] id: GO:0045725 name: positive regulation of glycogen biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of glycogen." [GOC:go_curators] synonym: "activation of glycogen biosynthetic process" NARROW [] synonym: "positive regulation of glycogen anabolism" EXACT [] synonym: "positive regulation of glycogen biosynthesis" EXACT [] synonym: "positive regulation of glycogen formation" EXACT [] synonym: "positive regulation of glycogen synthesis" EXACT [] synonym: "stimulation of glycogen biosynthetic process" NARROW [] synonym: "up regulation of glycogen biosynthetic process" EXACT [] synonym: "up-regulation of glycogen biosynthetic process" EXACT [] synonym: "upregulation of glycogen biosynthetic process" EXACT [] is_a: GO:0005979 ! regulation of glycogen biosynthetic process is_a: GO:0010557 ! positive regulation of macromolecule biosynthetic process is_a: GO:0070875 ! positive regulation of glycogen metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0005978 ! positively regulates glycogen biosynthetic process relationship: RO:0002213 GO:0005978 ! positively regulates glycogen biosynthetic process [Term] id: GO:0045727 name: positive regulation of translation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA." [GOC:dph, GOC:go_curators, GOC:tb] synonym: "activation of protein biosynthetic process" NARROW [] synonym: "positive regulation of protein anabolism" EXACT [] synonym: "positive regulation of protein biosynthesis" EXACT [] synonym: "positive regulation of protein biosynthetic process" EXACT [GOC:tb] synonym: "positive regulation of protein formation" EXACT [] synonym: "positive regulation of protein synthesis" EXACT [] synonym: "stimulation of protein biosynthetic process" NARROW [] synonym: "up regulation of protein biosynthetic process" EXACT [] synonym: "up-regulation of protein biosynthetic process" EXACT [] synonym: "upregulation of protein biosynthetic process" EXACT [] is_a: GO:0006417 ! regulation of translation is_a: GO:0010628 ! positive regulation of gene expression is_a: GO:0051247 ! positive regulation of protein metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0006412 ! positively regulates translation relationship: RO:0002213 GO:0006412 ! positively regulates translation [Term] id: GO:0045729 name: respiratory burst at fertilization namespace: biological_process def: "The phase of elevated metabolic activity, during which oxygen consumption increases, that occurs at fertilization. An enhanced uptake of oxygen leads to the production of hydrogen peroxide (H2O2), superoxide anions and hydroxyl radicals. Capacitation, a necessary prerequisite event to successful fertilization, can be induced by reactive oxygen species in vitro; hydrogen peroxide is used as an extracellular oxidant to cross-link the protective surface envelopes." [ISBN:0198506732, PMID:2537493, PMID:9013127] synonym: "metabolic burst at fertilization" EXACT [] synonym: "oxidative burst at fertilization" EXACT [] is_a: GO:0045730 ! respiratory burst intersection_of: GO:0045730 ! respiratory burst intersection_of: BFO:0000050 GO:0009566 ! part of fertilization relationship: BFO:0000050 GO:0007338 ! part of single fertilization property_value: RO:0002161 NCBITaxon:58024 [Term] id: GO:0045730 name: respiratory burst namespace: biological_process def: "A phase of elevated metabolic activity, during which oxygen consumption increases; this leads to the production, by an NADH dependent system, of hydrogen peroxide (H2O2), superoxide anions and hydroxyl radicals." [ISBN:0198506732] synonym: "metabolic burst" EXACT [] synonym: "oxidative burst" EXACT [] xref: Wikipedia:Respiratory_burst is_a: GO:0008152 ! metabolic process [Term] id: GO:0045732 name: positive regulation of protein catabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds." [GOC:go_curators] synonym: "activation of cellular protein breakdown" NARROW [GOC:TermGenie] synonym: "activation of cellular protein catabolic process" NARROW [GOC:TermGenie] synonym: "activation of cellular protein catabolism" NARROW [GOC:TermGenie] synonym: "activation of cellular protein degradation" NARROW [GOC:TermGenie] synonym: "activation of protein catabolic process" NARROW [] synonym: "positive regulation of cellular protein breakdown" EXACT [GOC:TermGenie] synonym: "positive regulation of cellular protein catabolic process" EXACT [] synonym: "positive regulation of cellular protein catabolism" EXACT [GOC:TermGenie] synonym: "positive regulation of cellular protein degradation" EXACT [GOC:TermGenie] synonym: "positive regulation of cyclin breakdown" NARROW [GOC:obol] synonym: "positive regulation of cyclin catabolic process" NARROW [] synonym: "positive regulation of cyclin catabolism" NARROW [GOC:obol] synonym: "positive regulation of cyclin degradation" NARROW [GOC:obol] synonym: "positive regulation of degradation of cyclin" NARROW [GOC:obol] synonym: "positive regulation of protein breakdown" EXACT [] synonym: "positive regulation of protein catabolism" EXACT [] synonym: "positive regulation of protein degradation" EXACT [] synonym: "stimulation of protein catabolic process" NARROW [] synonym: "up regulation of cellular protein breakdown" EXACT [GOC:TermGenie] synonym: "up regulation of cellular protein catabolic process" EXACT [GOC:TermGenie] synonym: "up regulation of cellular protein catabolism" EXACT [GOC:TermGenie] synonym: "up regulation of cellular protein degradation" EXACT [GOC:TermGenie] synonym: "up regulation of protein catabolic process" EXACT [] synonym: "up-regulation of cellular protein breakdown" EXACT [GOC:TermGenie] synonym: "up-regulation of cellular protein catabolic process" EXACT [GOC:TermGenie] synonym: "up-regulation of cellular protein catabolism" EXACT [GOC:TermGenie] synonym: "up-regulation of cellular protein degradation" EXACT [GOC:TermGenie] synonym: "up-regulation of protein catabolic process" EXACT [] synonym: "upregulation of cellular protein breakdown" EXACT [GOC:TermGenie] synonym: "upregulation of cellular protein catabolic process" EXACT [GOC:TermGenie] synonym: "upregulation of cellular protein catabolism" EXACT [GOC:TermGenie] synonym: "upregulation of cellular protein degradation" EXACT [GOC:TermGenie] synonym: "upregulation of protein catabolic process" EXACT [] is_a: GO:0009896 ! positive regulation of catabolic process is_a: GO:0042176 ! regulation of protein catabolic process is_a: GO:0051247 ! positive regulation of protein metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0030163 ! positively regulates protein catabolic process relationship: RO:0002213 GO:0030163 ! positively regulates protein catabolic process property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/23112" xsd:anyURI [Term] id: GO:0045744 name: negative regulation of G protein-coupled receptor signaling pathway namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of G protein-coupled receptor signaling pathway." [GOC:go_curators] synonym: "down regulation of G-protein coupled receptor protein signaling pathway" EXACT [] synonym: "down-regulation of G-protein coupled receptor protein signaling pathway" EXACT [] synonym: "downregulation of G-protein coupled receptor protein signaling pathway" EXACT [] synonym: "inhibition of G-protein coupled receptor protein signaling pathway" NARROW [] synonym: "negative regulation of G protein coupled receptor protein signaling pathway" EXACT [] synonym: "negative regulation of G protein coupled receptor protein signalling pathway" EXACT [] synonym: "negative regulation of G-protein coupled receptor protein signaling pathway" EXACT [] synonym: "negative regulation of G-protein coupled receptor protein signalling pathway" EXACT [] synonym: "negative regulation of G-protein-coupled receptor protein signalling pathway" EXACT [] synonym: "negative regulation of GPCR protein signaling pathway" EXACT [] synonym: "negative regulation of GPCR protein signalling pathway" EXACT [] is_a: GO:0008277 ! regulation of G protein-coupled receptor signaling pathway is_a: GO:0009968 ! negative regulation of signal transduction intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0007186 ! negatively regulates G protein-coupled receptor signaling pathway relationship: RO:0002212 GO:0007186 ! negatively regulates G protein-coupled receptor signaling pathway [Term] id: GO:0045745 name: positive regulation of G protein-coupled receptor signaling pathway namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of G protein-coupled receptor signaling pathway activity." [GOC:go_curators] synonym: "activation of G-protein coupled receptor protein signaling pathway" NARROW [] synonym: "positive regulation of G protein coupled receptor protein signaling pathway" EXACT [] synonym: "positive regulation of G protein coupled receptor protein signalling pathway" EXACT [] synonym: "positive regulation of G-protein coupled receptor protein signaling pathway" EXACT [] synonym: "positive regulation of G-protein coupled receptor protein signalling pathway" EXACT [] synonym: "positive regulation of G-protein-coupled receptor protein signaling pathway" EXACT [] synonym: "positive regulation of G-protein-coupled receptor protein signalling pathway" EXACT [] synonym: "positive regulation of GPCR protein signaling pathway" EXACT [] synonym: "positive regulation of GPCR protein signalling pathway" EXACT [] synonym: "stimulation of G-protein coupled receptor protein signaling pathway" NARROW [] synonym: "up regulation of G-protein coupled receptor protein signaling pathway" EXACT [] synonym: "up-regulation of G-protein coupled receptor protein signaling pathway" EXACT [] synonym: "upregulation of G-protein coupled receptor protein signaling pathway" EXACT [] is_a: GO:0008277 ! regulation of G protein-coupled receptor signaling pathway is_a: GO:0009967 ! positive regulation of signal transduction intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0007186 ! positively regulates G protein-coupled receptor signaling pathway relationship: RO:0002213 GO:0007186 ! positively regulates G protein-coupled receptor signaling pathway [Term] id: GO:0045759 name: negative regulation of action potential namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of action potential creation, propagation or termination. This typically occurs via modulation of the activity or expression of voltage-gated ion channels." [GOC:go_curators] synonym: "down regulation of action potential" EXACT [] synonym: "down-regulation of action potential" EXACT [] synonym: "downregulation of action potential" EXACT [] synonym: "inhibition of action potential" NARROW [] is_a: GO:0048519 ! negative regulation of biological process is_a: GO:0098900 ! regulation of action potential intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0001508 ! negatively regulates action potential relationship: RO:0002212 GO:0001508 ! negatively regulates action potential property_value: RO:0002161 NCBITaxon:4895 [Term] id: GO:0045760 name: positive regulation of action potential namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of action potential creation, propagation or termination. This typically occurs via modulation of the activity or expression of voltage-gated ion channels." [GOC:go_curators] synonym: "activation of action potential" NARROW [] synonym: "stimulation of action potential" NARROW [] synonym: "up regulation of action potential" EXACT [] synonym: "up-regulation of action potential" EXACT [] synonym: "upregulation of action potential" EXACT [] is_a: GO:0048518 ! positive regulation of biological process is_a: GO:0098900 ! regulation of action potential intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0001508 ! positively regulates action potential relationship: RO:0002213 GO:0001508 ! positively regulates action potential property_value: RO:0002161 NCBITaxon:4895 [Term] id: GO:0045763 name: negative regulation of amino acid metabolic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving amino acid." [GOC:go_curators] synonym: "down regulation of amino acid metabolic process" EXACT [] synonym: "down-regulation of amino acid metabolic process" EXACT [] synonym: "downregulation of amino acid metabolic process" EXACT [] synonym: "inhibition of amino acid metabolic process" NARROW [] synonym: "negative regulation of amino acid metabolism" EXACT [] is_a: GO:0006521 ! regulation of amino acid metabolic process is_a: GO:0009892 ! negative regulation of metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0006520 ! negatively regulates amino acid metabolic process relationship: RO:0002212 GO:0006520 ! negatively regulates amino acid metabolic process property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/28908" xsd:anyURI [Term] id: GO:0045764 name: positive regulation of amino acid metabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving amino acid." [GOC:go_curators] synonym: "activation of amino acid metabolic process" NARROW [] synonym: "positive regulation of amino acid metabolism" EXACT [] synonym: "positive regulation of cellular amino acid metabolic process" EXACT [] synonym: "stimulation of amino acid metabolic process" NARROW [] synonym: "up regulation of amino acid metabolic process" EXACT [] synonym: "up-regulation of amino acid metabolic process" EXACT [] synonym: "upregulation of amino acid metabolic process" EXACT [] is_a: GO:0006521 ! regulation of amino acid metabolic process is_a: GO:0009893 ! positive regulation of metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0006520 ! positively regulates amino acid metabolic process relationship: RO:0002213 GO:0006520 ! positively regulates amino acid metabolic process [Term] id: GO:0045765 name: regulation of angiogenesis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of angiogenesis." [GOC:go_curators] is_a: GO:0022603 ! regulation of anatomical structure morphogenesis is_a: GO:1901342 ! regulation of vasculature development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0001525 ! regulates angiogenesis relationship: RO:0002211 GO:0001525 ! regulates angiogenesis [Term] id: GO:0045766 name: positive regulation of angiogenesis namespace: biological_process def: "Any process that activates or increases angiogenesis." [GOC:go_curators] synonym: "activation of angiogenesis" NARROW [] synonym: "stimulation of angiogenesis" NARROW [] synonym: "up regulation of angiogenesis" EXACT [] synonym: "up-regulation of angiogenesis" EXACT [] synonym: "upregulation of angiogenesis" EXACT [] is_a: GO:0045765 ! regulation of angiogenesis is_a: GO:1904018 ! positive regulation of vasculature development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0001525 ! positively regulates angiogenesis relationship: RO:0002213 GO:0001525 ! positively regulates angiogenesis [Term] id: GO:0045769 name: negative regulation of asymmetric cell division namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of asymmetric cell division." [GOC:go_curators] synonym: "down regulation of asymmetric cell division" EXACT [] synonym: "down-regulation of asymmetric cell division" EXACT [] synonym: "downregulation of asymmetric cell division" EXACT [] synonym: "inhibition of asymmetric cell division" NARROW [] is_a: GO:0009786 ! regulation of asymmetric cell division is_a: GO:0051782 ! negative regulation of cell division intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0008356 ! negatively regulates asymmetric cell division relationship: RO:0002212 GO:0008356 ! negatively regulates asymmetric cell division [Term] id: GO:0045770 name: positive regulation of asymmetric cell division namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of asymmetric cell division." [GOC:go_curators] synonym: "activation of asymmetric cell division" NARROW [] synonym: "stimulation of asymmetric cell division" NARROW [] synonym: "up regulation of asymmetric cell division" EXACT [] synonym: "up-regulation of asymmetric cell division" EXACT [] synonym: "upregulation of asymmetric cell division" EXACT [] is_a: GO:0009786 ! regulation of asymmetric cell division is_a: GO:0051781 ! positive regulation of cell division intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0008356 ! positively regulates asymmetric cell division relationship: RO:0002213 GO:0008356 ! positively regulates asymmetric cell division [Term] id: GO:0045778 name: positive regulation of ossification namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of ossification, the formation of bone or of a bony substance or the conversion of fibrous tissue or of cartilage into bone or a bony substance." [GOC:go_curators] synonym: "activation of ossification" NARROW [] synonym: "positive regulation of bone biosynthesis" EXACT [] synonym: "positive regulation of bone formation" EXACT [] synonym: "stimulation of ossification" NARROW [] synonym: "up regulation of ossification" EXACT [] synonym: "up-regulation of ossification" EXACT [] synonym: "upregulation of ossification" EXACT [] is_a: GO:0030278 ! regulation of ossification is_a: GO:0051240 ! positive regulation of multicellular organismal process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0001503 ! positively regulates ossification relationship: RO:0002213 GO:0001503 ! positively regulates ossification [Term] id: GO:0045779 name: negative regulation of bone resorption namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of bone resorption." [GOC:go_curators] synonym: "down regulation of bone resorption" EXACT [] synonym: "down-regulation of bone resorption" EXACT [] synonym: "downregulation of bone resorption" EXACT [] synonym: "inhibition of bone resorption" NARROW [] is_a: GO:0045124 ! regulation of bone resorption is_a: GO:0046851 ! negative regulation of bone remodeling intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0045453 ! negatively regulates bone resorption relationship: RO:0002212 GO:0045453 ! negatively regulates bone resorption [Term] id: GO:0045780 name: positive regulation of bone resorption namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of bone resorption." [GOC:go_curators] synonym: "activation of bone resorption" NARROW [] synonym: "stimulation of bone resorption" NARROW [] synonym: "up regulation of bone resorption" EXACT [] synonym: "up-regulation of bone resorption" EXACT [] synonym: "upregulation of bone resorption" EXACT [] is_a: GO:0045124 ! regulation of bone resorption is_a: GO:0051240 ! positive regulation of multicellular organismal process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0045453 ! positively regulates bone resorption relationship: RO:0002213 GO:0045453 ! positively regulates bone resorption [Term] id: GO:0045785 name: positive regulation of cell adhesion namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cell adhesion." [GOC:go_curators] synonym: "activation of cell adhesion" NARROW [] synonym: "stimulation of cell adhesion" NARROW [] synonym: "up regulation of cell adhesion" EXACT [] synonym: "up-regulation of cell adhesion" EXACT [] synonym: "upregulation of cell adhesion" EXACT [] is_a: GO:0030155 ! regulation of cell adhesion is_a: GO:0048522 ! positive regulation of cellular process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0007155 ! positively regulates cell adhesion relationship: RO:0002213 GO:0007155 ! positively regulates cell adhesion [Term] id: GO:0045786 name: negative regulation of cell cycle namespace: biological_process def: "Any process that stops, prevents or reduces the rate or extent of progression through the cell cycle." [GOC:dph, GOC:go_curators, GOC:tb] synonym: "down regulation of progression through cell cycle" EXACT [] synonym: "down-regulation of progression through cell cycle" EXACT [] synonym: "downregulation of progression through cell cycle" EXACT [] synonym: "inhibition of progression through cell cycle" NARROW [] synonym: "negative regulation of cell cycle progression" EXACT [] synonym: "negative regulation of progression through cell cycle" EXACT [] xref: Reactome:R-HSA-193670 "p75NTR negatively regulates cell cycle via SC1" is_a: GO:0048523 ! negative regulation of cellular process is_a: GO:0051726 ! regulation of cell cycle intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0007049 ! negatively regulates cell cycle relationship: RO:0002212 GO:0007049 ! negatively regulates cell cycle [Term] id: GO:0045787 name: positive regulation of cell cycle namespace: biological_process def: "Any process that activates or increases the rate or extent of progression through the cell cycle." [GOC:go_curators] synonym: "activation of progression through cell cycle" NARROW [] synonym: "positive regulation of cell cycle progression" EXACT [] synonym: "positive regulation of progression through cell cycle" EXACT [GOC:dph, GOC:tb] synonym: "stimulation of progression through cell cycle" NARROW [] synonym: "up regulation of progression through cell cycle" EXACT [] synonym: "up-regulation of progression through cell cycle" EXACT [] synonym: "upregulation of progression through cell cycle" EXACT [] xref: Reactome:R-HSA-8849470 "PTK6 Regulates Cell Cycle" is_a: GO:0048522 ! positive regulation of cellular process is_a: GO:0051726 ! regulation of cell cycle intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0007049 ! positively regulates cell cycle relationship: RO:0002213 GO:0007049 ! positively regulates cell cycle [Term] id: GO:0045806 name: negative regulation of endocytosis namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of endocytosis." [GOC:go_curators] synonym: "down regulation of endocytosis" EXACT [] synonym: "down-regulation of endocytosis" EXACT [] synonym: "downregulation of endocytosis" EXACT [] synonym: "inhibition of endocytosis" NARROW [] is_a: GO:0030100 ! regulation of endocytosis is_a: GO:0051051 ! negative regulation of transport is_a: GO:0051129 ! negative regulation of cellular component organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0006897 ! negatively regulates endocytosis relationship: RO:0002212 GO:0006897 ! negatively regulates endocytosis [Term] id: GO:0045807 name: positive regulation of endocytosis namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of endocytosis." [GOC:go_curators] synonym: "activation of endocytosis" NARROW [] synonym: "stimulation of endocytosis" NARROW [] synonym: "up regulation of endocytosis" EXACT [] synonym: "up-regulation of endocytosis" EXACT [] synonym: "upregulation of endocytosis" EXACT [] is_a: GO:0030100 ! regulation of endocytosis is_a: GO:0051050 ! positive regulation of transport is_a: GO:0051130 ! positive regulation of cellular component organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0006897 ! positively regulates endocytosis relationship: RO:0002213 GO:0006897 ! positively regulates endocytosis [Term] id: GO:0045814 name: negative regulation of gene expression, epigenetic namespace: biological_process def: "An epigenetic process that silences gene expression at specific genomic regions through chromatin remodeling either by modifying higher order chromatin fiber structure, nucleosomal histones, or the cytosine DNA methylation." [PMID:22243696] synonym: "down regulation of gene expression, epigenetic" EXACT [] synonym: "down-regulation of gene expression, epigenetic" EXACT [] synonym: "downregulation of gene expression, epigenetic" EXACT [] synonym: "gene silencing" RELATED [] synonym: "inhibition of gene expression, epigenetic" NARROW [] xref: Reactome:R-HSA-212300 "PRC2 methylates histones and DNA" xref: Reactome:R-HSA-5250941 "Negative epigenetic regulation of rRNA expression" is_a: GO:0010629 ! negative regulation of gene expression is_a: GO:0040029 ! epigenetic regulation of gene expression property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/22201" xsd:anyURI property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/30601" xsd:anyURI [Term] id: GO:0045818 name: negative regulation of glycogen catabolic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of glycogen." [GOC:go_curators] synonym: "down regulation of glycogen catabolic process" EXACT [] synonym: "down-regulation of glycogen catabolic process" EXACT [] synonym: "downregulation of glycogen catabolic process" EXACT [] synonym: "inhibition of glycogen catabolic process" NARROW [] synonym: "negative regulation of glycogen breakdown" EXACT [] synonym: "negative regulation of glycogen catabolism" EXACT [] synonym: "negative regulation of glycogen degradation" EXACT [] synonym: "negative regulation of glycogenolysis" EXACT [GOC:sl] is_a: GO:0005981 ! regulation of glycogen catabolic process is_a: GO:0009895 ! negative regulation of catabolic process is_a: GO:0070874 ! negative regulation of glycogen metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0005980 ! negatively regulates glycogen catabolic process relationship: RO:0002212 GO:0005980 ! negatively regulates glycogen catabolic process property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/29024" xsd:anyURI [Term] id: GO:0045819 name: positive regulation of glycogen catabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of glycogen." [GOC:go_curators] synonym: "activation of glycogen catabolic process" NARROW [] synonym: "positive regulation of glycogen breakdown" EXACT [] synonym: "positive regulation of glycogen catabolism" EXACT [] synonym: "positive regulation of glycogen degradation" EXACT [] synonym: "positive regulation of glycogenolysis" EXACT [GOC:sl] synonym: "stimulation of glycogen catabolic process" NARROW [] synonym: "up regulation of glycogen catabolic process" EXACT [] synonym: "up-regulation of glycogen catabolic process" EXACT [] synonym: "upregulation of glycogen catabolic process" EXACT [] is_a: GO:0005981 ! regulation of glycogen catabolic process is_a: GO:0009896 ! positive regulation of catabolic process is_a: GO:0070875 ! positive regulation of glycogen metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0005980 ! positively regulates glycogen catabolic process relationship: RO:0002213 GO:0005980 ! positively regulates glycogen catabolic process property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/29024" xsd:anyURI [Term] id: GO:0045822 name: negative regulation of heart contraction namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of heart contraction." [GOC:go_curators] synonym: "down regulation of heart contraction" EXACT [] synonym: "down-regulation of heart contraction" EXACT [] synonym: "downregulation of heart contraction" EXACT [] synonym: "inhibition of heart contraction" NARROW [] synonym: "negative regulation of cardiac contraction" RELATED [] is_a: GO:0008016 ! regulation of heart contraction is_a: GO:1903523 ! negative regulation of blood circulation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0060047 ! negatively regulates heart contraction relationship: RO:0002212 GO:0060047 ! negatively regulates heart contraction property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0045823 name: positive regulation of heart contraction namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of heart contraction." [GOC:go_curators] synonym: "activation of heart contraction" NARROW [] synonym: "positive regulation of cardiac contraction" EXACT [] synonym: "stimulation of heart contraction" NARROW [] synonym: "up regulation of heart contraction" EXACT [] synonym: "up-regulation of heart contraction" EXACT [] synonym: "upregulation of heart contraction" EXACT [] is_a: GO:0008016 ! regulation of heart contraction is_a: GO:1903524 ! positive regulation of blood circulation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0060047 ! positively regulates heart contraction relationship: RO:0002213 GO:0060047 ! positively regulates heart contraction property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0045824 name: negative regulation of innate immune response namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the innate immune response." [GOC:go_curators] synonym: "down regulation of innate immune response" EXACT [] synonym: "down-regulation of innate immune response" EXACT [] synonym: "downregulation of innate immune response" EXACT [] synonym: "inhibition of innate immune response" NARROW [] is_a: GO:0002832 ! negative regulation of response to biotic stimulus is_a: GO:0031348 ! negative regulation of defense response is_a: GO:0032102 ! negative regulation of response to external stimulus is_a: GO:0045088 ! regulation of innate immune response is_a: GO:0050777 ! negative regulation of immune response intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0045087 ! negatively regulates innate immune response relationship: RO:0002212 GO:0045087 ! negatively regulates innate immune response property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4751 [Term] id: GO:0045827 name: negative regulation of isoprenoid metabolic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving isoprenoid." [GOC:go_curators] synonym: "down regulation of isoprenoid metabolic process" EXACT [] synonym: "down-regulation of isoprenoid metabolic process" EXACT [] synonym: "downregulation of isoprenoid metabolic process" EXACT [] synonym: "inhibition of isoprenoid metabolic process" NARROW [] synonym: "negative regulation of isoprenoid metabolism" EXACT [] is_a: GO:0019747 ! regulation of isoprenoid metabolic process is_a: GO:0045833 ! negative regulation of lipid metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0006720 ! negatively regulates isoprenoid metabolic process relationship: RO:0002212 GO:0006720 ! negatively regulates isoprenoid metabolic process [Term] id: GO:0045829 name: negative regulation of isotype switching namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of isotype switching." [GOC:go_curators] synonym: "down regulation of isotype switching" EXACT [] synonym: "down-regulation of isotype switching" EXACT [] synonym: "downregulation of isotype switching" EXACT [] synonym: "inhibition of isotype switching" NARROW [] synonym: "negative regulation of class switch recombination" EXACT [] synonym: "negative regulation of class switching" EXACT [] synonym: "negative regulation of isotype switch recombination" EXACT [] is_a: GO:0002638 ! negative regulation of immunoglobulin production is_a: GO:0002890 ! negative regulation of immunoglobulin mediated immune response is_a: GO:0045191 ! regulation of isotype switching is_a: GO:0045910 ! negative regulation of DNA recombination is_a: GO:0050869 ! negative regulation of B cell activation is_a: GO:0051093 ! negative regulation of developmental process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0045190 ! negatively regulates isotype switching relationship: RO:0002212 GO:0045190 ! negatively regulates isotype switching [Term] id: GO:0045830 name: positive regulation of isotype switching namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of isotype switching." [GOC:go_curators] synonym: "activation of isotype switching" NARROW [] synonym: "positive regulation of class switch recombination" EXACT [] synonym: "positive regulation of class switching" EXACT [] synonym: "positive regulation of isotype switch recombination" EXACT [] synonym: "stimulation of isotype switching" NARROW [] synonym: "up regulation of isotype switching" EXACT [] synonym: "up-regulation of isotype switching" EXACT [] synonym: "upregulation of isotype switching" EXACT [] is_a: GO:0002639 ! positive regulation of immunoglobulin production is_a: GO:0002891 ! positive regulation of immunoglobulin mediated immune response is_a: GO:0045191 ! regulation of isotype switching is_a: GO:0045911 ! positive regulation of DNA recombination is_a: GO:0050871 ! positive regulation of B cell activation is_a: GO:0051094 ! positive regulation of developmental process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0045190 ! positively regulates isotype switching relationship: RO:0002213 GO:0045190 ! positively regulates isotype switching [Term] id: GO:0045833 name: negative regulation of lipid metabolic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving lipids." [GOC:go_curators] synonym: "down regulation of lipid metabolic process" EXACT [] synonym: "down-regulation of lipid metabolic process" EXACT [] synonym: "downregulation of lipid metabolic process" EXACT [] synonym: "inhibition of lipid metabolic process" NARROW [] synonym: "negative regulation of lipid metabolism" EXACT [] is_a: GO:0009892 ! negative regulation of metabolic process is_a: GO:0019216 ! regulation of lipid metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0006629 ! negatively regulates lipid metabolic process relationship: RO:0002212 GO:0006629 ! negatively regulates lipid metabolic process [Term] id: GO:0045834 name: positive regulation of lipid metabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving lipids." [GOC:go_curators] synonym: "activation of lipid metabolic process" NARROW [] synonym: "positive regulation of lipid metabolism" EXACT [] synonym: "stimulation of lipid metabolic process" NARROW [] synonym: "up regulation of lipid metabolic process" EXACT [] synonym: "up-regulation of lipid metabolic process" EXACT [] synonym: "upregulation of lipid metabolic process" EXACT [] is_a: GO:0009893 ! positive regulation of metabolic process is_a: GO:0019216 ! regulation of lipid metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0006629 ! positively regulates lipid metabolic process relationship: RO:0002213 GO:0006629 ! positively regulates lipid metabolic process [Term] id: GO:0045835 name: negative regulation of meiotic nuclear division namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of meiosis." [GOC:go_curators] synonym: "down regulation of meiosis" EXACT [] synonym: "down-regulation of meiosis" EXACT [] synonym: "downregulation of meiosis" EXACT [] synonym: "inhibition of meiosis" NARROW [] synonym: "negative regulation of meiosis" EXACT [] is_a: GO:0010948 ! negative regulation of cell cycle process is_a: GO:0040020 ! regulation of meiotic nuclear division is_a: GO:0051447 ! negative regulation of meiotic cell cycle is_a: GO:0051784 ! negative regulation of nuclear division intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0140013 ! negatively regulates meiotic nuclear division relationship: RO:0002212 GO:0140013 ! negatively regulates meiotic nuclear division [Term] id: GO:0045836 name: positive regulation of meiotic nuclear division namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of meiosis." [GOC:go_curators] synonym: "activation of meiosis" NARROW [] synonym: "positive regulation of meiosis" EXACT [] synonym: "stimulation of meiosis" NARROW [] synonym: "up regulation of meiosis" EXACT [] synonym: "up-regulation of meiosis" EXACT [] synonym: "upregulation of meiosis" EXACT [] is_a: GO:0040020 ! regulation of meiotic nuclear division is_a: GO:0051446 ! positive regulation of meiotic cell cycle is_a: GO:0051785 ! positive regulation of nuclear division is_a: GO:0090068 ! positive regulation of cell cycle process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0140013 ! positively regulates meiotic nuclear division relationship: RO:0002213 GO:0140013 ! positively regulates meiotic nuclear division [Term] id: GO:0045839 name: negative regulation of mitotic nuclear division namespace: biological_process def: "Any process that stops, prevents or reduces the rate or extent of mitosis. Mitosis is the division of the eukaryotic cell nucleus to produce two daughter nuclei that, usually, contain the identical chromosome complement to their mother." [GOC:dph, GOC:go_curators, GOC:tb] synonym: "down regulation of mitosis" EXACT [] synonym: "down-regulation of mitosis" EXACT [] synonym: "downregulation of mitosis" EXACT [] synonym: "inhibition of mitosis" NARROW [] synonym: "negative regulation of mitosis" EXACT [] is_a: GO:0007088 ! regulation of mitotic nuclear division is_a: GO:0010948 ! negative regulation of cell cycle process is_a: GO:0045930 ! negative regulation of mitotic cell cycle is_a: GO:0051784 ! negative regulation of nuclear division intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0140014 ! negatively regulates mitotic nuclear division relationship: RO:0002212 GO:0140014 ! negatively regulates mitotic nuclear division [Term] id: GO:0045840 name: positive regulation of mitotic nuclear division namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of mitosis." [GOC:go_curators] synonym: "activation of mitosis" NARROW [] synonym: "mitogenic activity" NARROW [] synonym: "positive regulation of mitosis" EXACT [] synonym: "stimulation of mitosis" NARROW [] synonym: "up regulation of mitosis" EXACT [] synonym: "up-regulation of mitosis" EXACT [] synonym: "upregulation of mitosis" EXACT [] is_a: GO:0007088 ! regulation of mitotic nuclear division is_a: GO:0051785 ! positive regulation of nuclear division is_a: GO:0090068 ! positive regulation of cell cycle process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0140014 ! positively regulates mitotic nuclear division relationship: RO:0002213 GO:0140014 ! positively regulates mitotic nuclear division [Term] id: GO:0045843 name: negative regulation of striated muscle tissue development namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of striated muscle development." [GOC:go_curators] synonym: "down regulation of striated muscle development" EXACT [] synonym: "down-regulation of striated muscle development" EXACT [] synonym: "downregulation of striated muscle development" EXACT [] synonym: "inhibition of striated muscle development" NARROW [] is_a: GO:0016202 ! regulation of striated muscle tissue development is_a: GO:0048635 ! negative regulation of muscle organ development is_a: GO:1901862 ! negative regulation of muscle tissue development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0014706 ! negatively regulates striated muscle tissue development relationship: RO:0002212 GO:0014706 ! negatively regulates striated muscle tissue development [Term] id: GO:0045844 name: positive regulation of striated muscle tissue development namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of striated muscle development." [GOC:go_curators] synonym: "activation of striated muscle development" NARROW [] synonym: "stimulation of striated muscle development" NARROW [] synonym: "up regulation of striated muscle development" EXACT [] synonym: "up-regulation of striated muscle development" EXACT [] synonym: "upregulation of striated muscle development" EXACT [] is_a: GO:0016202 ! regulation of striated muscle tissue development is_a: GO:0048636 ! positive regulation of muscle organ development is_a: GO:1901863 ! positive regulation of muscle tissue development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0014706 ! positively regulates striated muscle tissue development relationship: RO:0002213 GO:0014706 ! positively regulates striated muscle tissue development [Term] id: GO:0045849 name: negative regulation of nurse cell apoptotic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of nurse cell apoptotic process." [GOC:go_curators, GOC:mtg_apoptosis] synonym: "down regulation of nurse cell apoptosis" EXACT [] synonym: "down-regulation of nurse cell apoptosis" EXACT [] synonym: "downregulation of nurse cell apoptosis" EXACT [] synonym: "inhibition of nurse cell apoptosis" NARROW [] synonym: "negative regulation of nurse cell apoptosis" NARROW [] is_a: GO:0045477 ! regulation of nurse cell apoptotic process is_a: GO:1904746 ! negative regulation of apoptotic process involved in development is_a: GO:2000242 ! negative regulation of reproductive process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0045476 ! negatively regulates nurse cell apoptotic process relationship: RO:0002212 GO:0045476 ! negatively regulates nurse cell apoptotic process [Term] id: GO:0045850 name: positive regulation of nurse cell apoptotic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of nurse cell apoptotic process." [GOC:go_curators, GOC:mtg_apoptosis] synonym: "activation of nurse cell apoptosis" NARROW [] synonym: "positive regulation of nurse cell apoptosis" NARROW [] synonym: "stimulation of nurse cell apoptosis" NARROW [] synonym: "up regulation of nurse cell apoptosis" EXACT [] synonym: "up-regulation of nurse cell apoptosis" EXACT [] synonym: "upregulation of nurse cell apoptosis" EXACT [] is_a: GO:0045477 ! regulation of nurse cell apoptotic process is_a: GO:1904747 ! positive regulation of apoptotic process involved in development is_a: GO:2000243 ! positive regulation of reproductive process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0045476 ! positively regulates nurse cell apoptotic process relationship: RO:0002213 GO:0045476 ! positively regulates nurse cell apoptotic process [Term] id: GO:0045859 name: regulation of protein kinase activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of protein kinase activity." [GOC:go_curators] subset: gocheck_obsoletion_candidate is_a: GO:0001932 ! regulation of protein phosphorylation is_a: GO:0043549 ! regulation of kinase activity intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0004672 ! regulates protein kinase activity relationship: RO:0002211 GO:0004672 ! regulates protein kinase activity [Term] id: GO:0045860 name: positive regulation of protein kinase activity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of protein kinase activity." [GOC:go_curators] subset: gocheck_obsoletion_candidate synonym: "stimulation of protein kinase activity" NARROW [] synonym: "up regulation of protein kinase activity" EXACT [] synonym: "up-regulation of protein kinase activity" EXACT [] synonym: "upregulation of protein kinase activity" EXACT [] is_a: GO:0001934 ! positive regulation of protein phosphorylation is_a: GO:0033674 ! positive regulation of kinase activity is_a: GO:0045859 ! regulation of protein kinase activity intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0004672 ! positively regulates protein kinase activity relationship: RO:0002213 GO:0004672 ! positively regulates protein kinase activity [Term] id: GO:0045861 name: negative regulation of proteolysis namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the hydrolysis of a peptide bond or bonds within a protein." [GOC:go_curators] synonym: "down regulation of proteolysis" EXACT [] synonym: "down-regulation of proteolysis" EXACT [] synonym: "downregulation of proteolysis" EXACT [] synonym: "inhibition of proteolysis" NARROW [] synonym: "negative regulation of peptidolysis" EXACT [] is_a: GO:0030162 ! regulation of proteolysis is_a: GO:0051248 ! negative regulation of protein metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0006508 ! negatively regulates proteolysis relationship: RO:0002212 GO:0006508 ! negatively regulates proteolysis [Term] id: GO:0045862 name: positive regulation of proteolysis namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the hydrolysis of a peptide bond or bonds within a protein." [GOC:go_curators] synonym: "activation of proteolysis" NARROW [] synonym: "positive regulation of peptidolysis" EXACT [] synonym: "stimulation of proteolysis" NARROW [] synonym: "up regulation of proteolysis" EXACT [] synonym: "up-regulation of proteolysis" EXACT [] synonym: "upregulation of proteolysis" EXACT [] is_a: GO:0030162 ! regulation of proteolysis is_a: GO:0051247 ! positive regulation of protein metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0006508 ! positively regulates proteolysis relationship: RO:0002213 GO:0006508 ! positively regulates proteolysis [Term] id: GO:0045881 name: positive regulation of sporulation resulting in formation of a cellular spore namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of sporulation." [GOC:go_curators] synonym: "activation of sporulation" NARROW [] synonym: "stimulation of sporulation" NARROW [] synonym: "up regulation of sporulation" EXACT [] synonym: "up-regulation of sporulation" EXACT [] synonym: "upregulation of sporulation" EXACT [] is_a: GO:0042173 ! regulation of sporulation resulting in formation of a cellular spore is_a: GO:0043938 ! positive regulation of sporulation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0030435 ! positively regulates sporulation resulting in formation of a cellular spore relationship: RO:0002213 GO:0030435 ! positively regulates sporulation resulting in formation of a cellular spore [Term] id: GO:0045900 name: negative regulation of translational elongation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of translational elongation." [GOC:go_curators] synonym: "down regulation of translational elongation" EXACT [] synonym: "down-regulation of translational elongation" EXACT [] synonym: "downregulation of translational elongation" EXACT [] synonym: "inhibition of translational elongation" NARROW [] is_a: GO:0006448 ! regulation of translational elongation is_a: GO:0017148 ! negative regulation of translation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0006414 ! negatively regulates translational elongation relationship: RO:0002212 GO:0006414 ! negatively regulates translational elongation [Term] id: GO:0045901 name: positive regulation of translational elongation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of translational elongation." [GOC:go_curators] synonym: "activation of translational elongation" NARROW [] synonym: "stimulation of translational elongation" NARROW [] synonym: "up regulation of translational elongation" EXACT [] synonym: "up-regulation of translational elongation" EXACT [] synonym: "upregulation of translational elongation" EXACT [] is_a: GO:0006448 ! regulation of translational elongation is_a: GO:0045727 ! positive regulation of translation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0006414 ! positively regulates translational elongation relationship: RO:0002213 GO:0006414 ! positively regulates translational elongation [Term] id: GO:0045904 name: negative regulation of translational termination namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of translational termination." [GOC:go_curators] synonym: "down regulation of translational termination" EXACT [] synonym: "down-regulation of translational termination" EXACT [] synonym: "downregulation of translational termination" EXACT [] synonym: "inhibition of translational termination" NARROW [] is_a: GO:0006449 ! regulation of translational termination is_a: GO:0017148 ! negative regulation of translation is_a: GO:0043242 ! negative regulation of protein-containing complex disassembly intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0006415 ! negatively regulates translational termination relationship: RO:0002212 GO:0006415 ! negatively regulates translational termination [Term] id: GO:0045905 name: positive regulation of translational termination namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of translational termination." [GOC:go_curators] synonym: "activation of translational termination" NARROW [] synonym: "stimulation of translational termination" NARROW [] synonym: "up regulation of translational termination" EXACT [] synonym: "up-regulation of translational termination" EXACT [] synonym: "upregulation of translational termination" EXACT [] is_a: GO:0006449 ! regulation of translational termination is_a: GO:0043243 ! positive regulation of protein-containing complex disassembly is_a: GO:0045727 ! positive regulation of translation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0006415 ! positively regulates translational termination relationship: RO:0002213 GO:0006415 ! positively regulates translational termination [Term] id: GO:0045910 name: negative regulation of DNA recombination namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of DNA recombination." [GOC:go_curators] synonym: "down regulation of DNA recombination" EXACT [] synonym: "down-regulation of DNA recombination" EXACT [] synonym: "downregulation of DNA recombination" EXACT [] synonym: "inhibition of DNA recombination" NARROW [] is_a: GO:0000018 ! regulation of DNA recombination is_a: GO:0051053 ! negative regulation of DNA metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0006310 ! negatively regulates DNA recombination relationship: RO:0002212 GO:0006310 ! negatively regulates DNA recombination [Term] id: GO:0045911 name: positive regulation of DNA recombination namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of DNA recombination." [GOC:go_curators] synonym: "activation of DNA recombination" NARROW [] synonym: "stimulation of DNA recombination" NARROW [] synonym: "up regulation of DNA recombination" EXACT [] synonym: "up-regulation of DNA recombination" EXACT [] synonym: "upregulation of DNA recombination" EXACT [] is_a: GO:0000018 ! regulation of DNA recombination is_a: GO:0051054 ! positive regulation of DNA metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0006310 ! positively regulates DNA recombination relationship: RO:0002213 GO:0006310 ! positively regulates DNA recombination [Term] id: GO:0045912 name: negative regulation of carbohydrate metabolic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving carbohydrate." [GOC:go_curators] synonym: "down regulation of carbohydrate metabolic process" EXACT [] synonym: "down-regulation of carbohydrate metabolic process" EXACT [] synonym: "downregulation of carbohydrate metabolic process" EXACT [] synonym: "inhibition of carbohydrate metabolic process" NARROW [] synonym: "negative regulation of carbohydrate metabolism" EXACT [] is_a: GO:0006109 ! regulation of carbohydrate metabolic process is_a: GO:0009892 ! negative regulation of metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0005975 ! negatively regulates carbohydrate metabolic process relationship: RO:0002212 GO:0005975 ! negatively regulates carbohydrate metabolic process [Term] id: GO:0045913 name: positive regulation of carbohydrate metabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving carbohydrate." [GOC:go_curators] synonym: "activation of carbohydrate metabolic process" NARROW [] synonym: "positive regulation of carbohydrate metabolism" EXACT [] synonym: "stimulation of carbohydrate metabolic process" NARROW [] synonym: "up regulation of carbohydrate metabolic process" EXACT [] synonym: "up-regulation of carbohydrate metabolic process" EXACT [] synonym: "upregulation of carbohydrate metabolic process" EXACT [] is_a: GO:0006109 ! regulation of carbohydrate metabolic process is_a: GO:0009893 ! positive regulation of metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0005975 ! positively regulates carbohydrate metabolic process relationship: RO:0002213 GO:0005975 ! positively regulates carbohydrate metabolic process [Term] id: GO:0045920 name: negative regulation of exocytosis namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of exocytosis." [GOC:go_curators] synonym: "down regulation of exocytosis" EXACT [] synonym: "down-regulation of exocytosis" EXACT [] synonym: "downregulation of exocytosis" EXACT [] synonym: "inhibition of exocytosis" NARROW [] is_a: GO:0017157 ! regulation of exocytosis is_a: GO:1903531 ! negative regulation of secretion by cell intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0006887 ! negatively regulates exocytosis relationship: RO:0002212 GO:0006887 ! negatively regulates exocytosis [Term] id: GO:0045921 name: positive regulation of exocytosis namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of exocytosis." [GOC:go_curators] synonym: "activation of exocytosis" NARROW [] synonym: "stimulation of exocytosis" NARROW [] synonym: "up regulation of exocytosis" EXACT [] synonym: "up-regulation of exocytosis" EXACT [] synonym: "upregulation of exocytosis" EXACT [] is_a: GO:0017157 ! regulation of exocytosis is_a: GO:1903532 ! positive regulation of secretion by cell intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0006887 ! positively regulates exocytosis relationship: RO:0002213 GO:0006887 ! positively regulates exocytosis [Term] id: GO:0045922 name: negative regulation of fatty acid metabolic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving fatty acids." [GOC:go_curators] synonym: "down regulation of fatty acid metabolic process" EXACT [] synonym: "down-regulation of fatty acid metabolic process" EXACT [] synonym: "downregulation of fatty acid metabolic process" EXACT [] synonym: "inhibition of fatty acid metabolic process" NARROW [] synonym: "negative regulation of fatty acid metabolism" EXACT [] is_a: GO:0019217 ! regulation of fatty acid metabolic process is_a: GO:0045833 ! negative regulation of lipid metabolic process is_a: GO:0062014 ! negative regulation of small molecule metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0006631 ! negatively regulates fatty acid metabolic process relationship: RO:0002212 GO:0006631 ! negatively regulates fatty acid metabolic process [Term] id: GO:0045923 name: positive regulation of fatty acid metabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving fatty acids." [GOC:go_curators] synonym: "activation of fatty acid metabolic process" NARROW [] synonym: "positive regulation of fatty acid metabolism" EXACT [] synonym: "stimulation of fatty acid metabolic process" NARROW [] synonym: "up regulation of fatty acid metabolic process" EXACT [] synonym: "up-regulation of fatty acid metabolic process" EXACT [] synonym: "upregulation of fatty acid metabolic process" EXACT [] is_a: GO:0019217 ! regulation of fatty acid metabolic process is_a: GO:0045834 ! positive regulation of lipid metabolic process is_a: GO:0062013 ! positive regulation of small molecule metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0006631 ! positively regulates fatty acid metabolic process relationship: RO:0002213 GO:0006631 ! positively regulates fatty acid metabolic process [Term] id: GO:0045926 name: negative regulation of growth namespace: biological_process def: "Any process that stops, prevents or reduces the rate or extent of growth, the increase in size or mass of all or part of an organism." [GOC:go_curators] synonym: "down regulation of growth" EXACT [] synonym: "down-regulation of growth" EXACT [] synonym: "downregulation of growth" EXACT [] synonym: "inhibition of growth" NARROW [] is_a: GO:0040008 ! regulation of growth is_a: GO:0048519 ! negative regulation of biological process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0040007 ! negatively regulates growth relationship: RO:0002212 GO:0040007 ! negatively regulates growth [Term] id: GO:0045927 name: positive regulation of growth namespace: biological_process def: "Any process that activates or increases the rate or extent of growth, the increase in size or mass of all or part of an organism." [GOC:go_curators] synonym: "activation of growth" NARROW [] synonym: "stimulation of growth" NARROW [] synonym: "up regulation of growth" EXACT [] synonym: "up-regulation of growth" EXACT [] synonym: "upregulation of growth" EXACT [] is_a: GO:0040008 ! regulation of growth is_a: GO:0048518 ! positive regulation of biological process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0040007 ! positively regulates growth relationship: RO:0002213 GO:0040007 ! positively regulates growth [Term] id: GO:0045928 name: negative regulation of juvenile hormone metabolic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving juvenile hormone." [GOC:go_curators] synonym: "down regulation of juvenile hormone metabolic process" EXACT [] synonym: "down-regulation of juvenile hormone metabolic process" EXACT [] synonym: "downregulation of juvenile hormone metabolic process" EXACT [] synonym: "inhibition of juvenile hormone metabolic process" NARROW [] synonym: "negative regulation of juvenile hormone metabolism" EXACT [] is_a: GO:0032351 ! negative regulation of hormone metabolic process is_a: GO:0045827 ! negative regulation of isoprenoid metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0006716 ! negatively regulates juvenile hormone metabolic process relationship: RO:0002212 GO:0006716 ! negatively regulates juvenile hormone metabolic process property_value: RO:0002161 NCBITaxon:4895 [Term] id: GO:0045930 name: negative regulation of mitotic cell cycle namespace: biological_process def: "Any process that stops, prevents or reduces the rate or extent of progression through the mitotic cell cycle." [GOC:dph, GOC:go_curators, GOC:tb] synonym: "down regulation of progression through mitotic cell cycle" EXACT [] synonym: "down-regulation of progression through mitotic cell cycle" EXACT [] synonym: "downregulation of progression through mitotic cell cycle" EXACT [] synonym: "inhibition of progression through mitotic cell cycle" NARROW [] synonym: "negative regulation of mitotic cell cycle progression" EXACT [] synonym: "negative regulation of progression through mitotic cell cycle" EXACT [GOC:dph, GOC:tb] xref: Reactome:R-HSA-8854050 "FBXL7 down-regulates AURKA during mitotic entry and in early mitosis" is_a: GO:0007346 ! regulation of mitotic cell cycle is_a: GO:0045786 ! negative regulation of cell cycle intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0000278 ! negatively regulates mitotic cell cycle relationship: RO:0002212 GO:0000278 ! negatively regulates mitotic cell cycle [Term] id: GO:0045931 name: positive regulation of mitotic cell cycle namespace: biological_process def: "Any process that activates or increases the rate or extent of progression through the mitotic cell cycle." [GOC:dph, GOC:go_curators, GOC:tb] synonym: "activation of progression through mitotic cell cycle" NARROW [] synonym: "positive regulation of mitotic cell cycle progression" EXACT [] synonym: "positive regulation of progression through mitotic cell cycle" EXACT [GOC:dph, GOC:tb] synonym: "stimulation of progression through mitotic cell cycle" NARROW [] synonym: "up regulation of progression through mitotic cell cycle" EXACT [] synonym: "up-regulation of progression through mitotic cell cycle" EXACT [] synonym: "upregulation of progression through mitotic cell cycle" EXACT [] is_a: GO:0007346 ! regulation of mitotic cell cycle is_a: GO:0045787 ! positive regulation of cell cycle intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0000278 ! positively regulates mitotic cell cycle relationship: RO:0002213 GO:0000278 ! positively regulates mitotic cell cycle [Term] id: GO:0045932 name: negative regulation of muscle contraction namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of muscle contraction." [GOC:go_curators] synonym: "down regulation of muscle contraction" EXACT [] synonym: "down-regulation of muscle contraction" EXACT [] synonym: "downregulation of muscle contraction" EXACT [] synonym: "inhibition of muscle contraction" NARROW [] is_a: GO:0006937 ! regulation of muscle contraction is_a: GO:0051241 ! negative regulation of multicellular organismal process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0006936 ! negatively regulates muscle contraction relationship: RO:0002212 GO:0006936 ! negatively regulates muscle contraction property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0045933 name: positive regulation of muscle contraction namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of muscle contraction." [GOC:go_curators] synonym: "activation of muscle contraction" NARROW [] synonym: "stimulation of muscle contraction" NARROW [] synonym: "up regulation of muscle contraction" EXACT [] synonym: "up-regulation of muscle contraction" EXACT [] synonym: "upregulation of muscle contraction" EXACT [] is_a: GO:0006937 ! regulation of muscle contraction is_a: GO:0051240 ! positive regulation of multicellular organismal process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0006936 ! positively regulates muscle contraction relationship: RO:0002213 GO:0006936 ! positively regulates muscle contraction property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0045934 name: negative regulation of nucleobase-containing compound metabolic process namespace: biological_process def: "Any cellular process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:go_curators] synonym: "down regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process" EXACT [] synonym: "down-regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process" EXACT [] synonym: "downregulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process" EXACT [] synonym: "inhibition of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process" NARROW [] synonym: "negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process" RELATED [GOC:dph, GOC:tb] synonym: "negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism" EXACT [] is_a: GO:0009892 ! negative regulation of metabolic process is_a: GO:0019219 ! regulation of nucleobase-containing compound metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0006139 ! negatively regulates nucleobase-containing compound metabolic process relationship: RO:0002212 GO:0006139 ! negatively regulates nucleobase-containing compound metabolic process [Term] id: GO:0045936 name: negative regulation of phosphate metabolic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving phosphates." [GOC:go_curators] synonym: "down regulation of phosphate metabolic process" EXACT [] synonym: "down-regulation of phosphate metabolic process" EXACT [] synonym: "downregulation of phosphate metabolic process" EXACT [] synonym: "inhibition of phosphate metabolic process" NARROW [] synonym: "negative regulation of phosphate metabolism" EXACT [] is_a: GO:0010563 ! negative regulation of phosphorus metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0006796 ! negatively regulates phosphate-containing compound metabolic process relationship: RO:0002212 GO:0006796 ! negatively regulates phosphate-containing compound metabolic process [Term] id: GO:0045937 name: positive regulation of phosphate metabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving phosphates." [GOC:go_curators] synonym: "activation of phosphate metabolic process" NARROW [] synonym: "positive regulation of phosphate metabolism" EXACT [] synonym: "stimulation of phosphate metabolic process" NARROW [] synonym: "up regulation of phosphate metabolic process" EXACT [] synonym: "up-regulation of phosphate metabolic process" EXACT [] synonym: "upregulation of phosphate metabolic process" EXACT [] is_a: GO:0010562 ! positive regulation of phosphorus metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0006796 ! positively regulates phosphate-containing compound metabolic process relationship: RO:0002213 GO:0006796 ! positively regulates phosphate-containing compound metabolic process [Term] id: GO:0045939 name: negative regulation of steroid metabolic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving steroids." [GOC:go_curators] synonym: "down regulation of steroid metabolic process" EXACT [] synonym: "down-regulation of steroid metabolic process" EXACT [] synonym: "downregulation of steroid metabolic process" EXACT [] synonym: "inhibition of steroid metabolic process" NARROW [] synonym: "negative regulation of steroid metabolism" EXACT [] is_a: GO:0019218 ! regulation of steroid metabolic process is_a: GO:0045833 ! negative regulation of lipid metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0008202 ! negatively regulates steroid metabolic process relationship: RO:0002212 GO:0008202 ! negatively regulates steroid metabolic process [Term] id: GO:0045940 name: positive regulation of steroid metabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving steroids." [GOC:go_curators] synonym: "activation of steroid metabolic process" NARROW [] synonym: "positive regulation of steroid metabolism" EXACT [] synonym: "stimulation of steroid metabolic process" NARROW [] synonym: "up regulation of steroid metabolic process" EXACT [] synonym: "up-regulation of steroid metabolic process" EXACT [] synonym: "upregulation of steroid metabolic process" EXACT [] is_a: GO:0019218 ! regulation of steroid metabolic process is_a: GO:0045834 ! positive regulation of lipid metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0008202 ! positively regulates steroid metabolic process relationship: RO:0002213 GO:0008202 ! positively regulates steroid metabolic process [Term] id: GO:0045947 name: negative regulation of translational initiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of translational initiation." [GOC:go_curators] synonym: "down regulation of translational initiation" EXACT [] synonym: "down-regulation of translational initiation" EXACT [] synonym: "downregulation of translational initiation" EXACT [] synonym: "inhibition of translational initiation" NARROW [] is_a: GO:0006446 ! regulation of translational initiation is_a: GO:0017148 ! negative regulation of translation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0006413 ! negatively regulates translational initiation relationship: RO:0002212 GO:0006413 ! negatively regulates translational initiation [Term] id: GO:0045948 name: positive regulation of translational initiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of translational initiation." [GOC:go_curators] synonym: "activation of translational initiation" NARROW [] synonym: "stimulation of translational initiation" NARROW [] synonym: "up regulation of translational initiation" EXACT [] synonym: "up-regulation of translational initiation" EXACT [] synonym: "upregulation of translational initiation" EXACT [] is_a: GO:0006446 ! regulation of translational initiation is_a: GO:0045727 ! positive regulation of translation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0006413 ! positively regulates translational initiation relationship: RO:0002213 GO:0006413 ! positively regulates translational initiation [Term] id: GO:0045952 name: regulation of juvenile hormone catabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of juvenile hormone." [GOC:go_curators] synonym: "regulation of juvenile hormone breakdown" EXACT [] synonym: "regulation of juvenile hormone catabolism" EXACT [] synonym: "regulation of juvenile hormone degradation" EXACT [] is_a: GO:0019747 ! regulation of isoprenoid metabolic process is_a: GO:0032350 ! regulation of hormone metabolic process is_a: GO:0050994 ! regulation of lipid catabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0006719 ! regulates juvenile hormone catabolic process relationship: RO:0002211 GO:0006719 ! regulates juvenile hormone catabolic process property_value: RO:0002161 NCBITaxon:4895 [Term] id: GO:0045953 name: negative regulation of natural killer cell mediated cytotoxicity namespace: biological_process def: "Any process that stops, prevents, or reduces the rate of natural killer mediated cytotoxicity." [GOC:add, ISBN:0781735149] synonym: "down regulation of natural killer cell mediated cytotoxicity" EXACT [] synonym: "down-regulation of natural killer cell mediated cytotoxicity" EXACT [] synonym: "downregulation of natural killer cell mediated cytotoxicity" EXACT [] synonym: "inhibition of natural killer cell mediated cytotoxicity" NARROW [] synonym: "negative regulation of natural killer cell mediated cell death" EXACT [] synonym: "negative regulation of natural killer cell mediated cell killing" EXACT [] synonym: "negative regulation of natural killer cell mediated cytolysis" RELATED [] synonym: "negative regulation of NK cell mediated cell death" EXACT [] synonym: "negative regulation of NK cell mediated cell killing" EXACT [] synonym: "negative regulation of NK cell mediated cytolysis" RELATED [] synonym: "negative regulation of NK cell mediated cytotoxicity" EXACT [] is_a: GO:0001911 ! negative regulation of leukocyte mediated cytotoxicity is_a: GO:0002716 ! negative regulation of natural killer cell mediated immunity is_a: GO:0042269 ! regulation of natural killer cell mediated cytotoxicity intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0042267 ! negatively regulates natural killer cell mediated cytotoxicity relationship: RO:0002212 GO:0042267 ! negatively regulates natural killer cell mediated cytotoxicity [Term] id: GO:0045954 name: positive regulation of natural killer cell mediated cytotoxicity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of natural killer cell mediated cytotoxicity." [GOC:add, ISBN:0781735149] synonym: "activation of natural killer cell mediated cytotoxicity" NARROW [] synonym: "positive regulation of natural killer cell mediated cell death" EXACT [] synonym: "positive regulation of natural killer cell mediated cell killing" EXACT [] synonym: "positive regulation of natural killer cell mediated cytolysis" RELATED [] synonym: "positive regulation of NK cell mediated cell death" EXACT [] synonym: "positive regulation of NK cell mediated cell killing" EXACT [] synonym: "positive regulation of NK cell mediated cytolysis" RELATED [] synonym: "positive regulation of NK cell mediated cytotoxicity" EXACT [] synonym: "stimulation of natural killer cell mediated cytotoxicity" NARROW [] synonym: "up regulation of natural killer cell mediated cytotoxicity" EXACT [] synonym: "up-regulation of natural killer cell mediated cytotoxicity" EXACT [] synonym: "upregulation of natural killer cell mediated cytotoxicity" EXACT [] is_a: GO:0001912 ! positive regulation of leukocyte mediated cytotoxicity is_a: GO:0002717 ! positive regulation of natural killer cell mediated immunity is_a: GO:0042269 ! regulation of natural killer cell mediated cytotoxicity intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0042267 ! positively regulates natural killer cell mediated cytotoxicity relationship: RO:0002213 GO:0042267 ! positively regulates natural killer cell mediated cytotoxicity [Term] id: GO:0045955 name: negative regulation of calcium ion-dependent exocytosis namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of calcium ion-dependent exocytosis." [GOC:go_curators] synonym: "down regulation of calcium ion-dependent exocytosis" EXACT [] synonym: "down-regulation of calcium ion-dependent exocytosis" EXACT [] synonym: "downregulation of calcium ion-dependent exocytosis" EXACT [] synonym: "inhibition of calcium ion-dependent exocytosis" NARROW [] is_a: GO:0017158 ! regulation of calcium ion-dependent exocytosis is_a: GO:1903306 ! negative regulation of regulated secretory pathway intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0017156 ! negatively regulates calcium-ion regulated exocytosis relationship: RO:0002212 GO:0017156 ! negatively regulates calcium-ion regulated exocytosis [Term] id: GO:0045956 name: positive regulation of calcium ion-dependent exocytosis namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of calcium ion-dependent exocytosis." [GOC:go_curators] synonym: "activation of calcium ion-dependent exocytosis" NARROW [] synonym: "stimulation of calcium ion-dependent exocytosis" NARROW [] synonym: "up regulation of calcium ion-dependent exocytosis" EXACT [] synonym: "up-regulation of calcium ion-dependent exocytosis" EXACT [] synonym: "upregulation of calcium ion-dependent exocytosis" EXACT [] is_a: GO:0017158 ! regulation of calcium ion-dependent exocytosis is_a: GO:1903307 ! positive regulation of regulated secretory pathway intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0017156 ! positively regulates calcium-ion regulated exocytosis relationship: RO:0002213 GO:0017156 ! positively regulates calcium-ion regulated exocytosis [Term] id: GO:0045963 name: negative regulation of dopamine metabolic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving dopamine." [GOC:go_curators] synonym: "down regulation of dopamine metabolic process" EXACT [] synonym: "down-regulation of dopamine metabolic process" EXACT [] synonym: "downregulation of dopamine metabolic process" EXACT [] synonym: "inhibition of dopamine metabolic process" NARROW [] synonym: "negative regulation of dopamine metabolism" EXACT [] is_a: GO:0033239 ! negative regulation of amine metabolic process is_a: GO:0042053 ! regulation of dopamine metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0042417 ! negatively regulates dopamine metabolic process relationship: RO:0002212 GO:0042417 ! negatively regulates dopamine metabolic process property_value: RO:0002161 NCBITaxon:4751 [Term] id: GO:0045964 name: positive regulation of dopamine metabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving dopamine." [GOC:go_curators] synonym: "activation of dopamine metabolic process" NARROW [] synonym: "positive regulation of dopamine metabolism" EXACT [] synonym: "stimulation of dopamine metabolic process" NARROW [] synonym: "up regulation of dopamine metabolic process" EXACT [] synonym: "up-regulation of dopamine metabolic process" EXACT [] synonym: "upregulation of dopamine metabolic process" EXACT [] is_a: GO:0033240 ! positive regulation of amine metabolic process is_a: GO:0042053 ! regulation of dopamine metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0042417 ! positively regulates dopamine metabolic process relationship: RO:0002213 GO:0042417 ! positively regulates dopamine metabolic process property_value: RO:0002161 NCBITaxon:4751 [Term] id: GO:0045968 name: negative regulation of juvenile hormone biosynthetic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of juvenile hormone." [GOC:go_curators] synonym: "down regulation of juvenile hormone biosynthetic process" EXACT [] synonym: "down-regulation of juvenile hormone biosynthetic process" EXACT [] synonym: "downregulation of juvenile hormone biosynthetic process" EXACT [] synonym: "inhibition of juvenile hormone biosynthetic process" NARROW [] synonym: "negative regulation of juvenile hormone anabolism" EXACT [] synonym: "negative regulation of juvenile hormone biosynthesis" EXACT [] synonym: "negative regulation of juvenile hormone formation" EXACT [] synonym: "negative regulation of juvenile hormone synthesis" EXACT [] is_a: GO:0007557 ! regulation of juvenile hormone biosynthetic process is_a: GO:0032353 ! negative regulation of hormone biosynthetic process is_a: GO:0045928 ! negative regulation of juvenile hormone metabolic process is_a: GO:0051055 ! negative regulation of lipid biosynthetic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0006718 ! negatively regulates juvenile hormone biosynthetic process relationship: RO:0002212 GO:0006718 ! negatively regulates juvenile hormone biosynthetic process property_value: RO:0002161 NCBITaxon:4895 [Term] id: GO:0045969 name: positive regulation of juvenile hormone biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of juvenile hormone." [GOC:go_curators] synonym: "activation of juvenile hormone biosynthetic process" NARROW [] synonym: "positive regulation of juvenile hormone anabolism" EXACT [] synonym: "positive regulation of juvenile hormone biosynthesis" EXACT [] synonym: "positive regulation of juvenile hormone formation" EXACT [] synonym: "positive regulation of juvenile hormone synthesis" EXACT [] synonym: "stimulation of juvenile hormone biosynthetic process" NARROW [] synonym: "up regulation of juvenile hormone biosynthetic process" EXACT [] synonym: "up-regulation of juvenile hormone biosynthetic process" EXACT [] synonym: "upregulation of juvenile hormone biosynthetic process" EXACT [] is_a: GO:0007557 ! regulation of juvenile hormone biosynthetic process is_a: GO:0046886 ! positive regulation of hormone biosynthetic process is_a: GO:0046889 ! positive regulation of lipid biosynthetic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0006718 ! positively regulates juvenile hormone biosynthetic process relationship: RO:0002213 GO:0006718 ! positively regulates juvenile hormone biosynthetic process property_value: RO:0002161 NCBITaxon:4895 [Term] id: GO:0045970 name: negative regulation of juvenile hormone catabolic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of juvenile hormone." [GOC:go_curators] synonym: "down regulation of juvenile hormone catabolic process" EXACT [] synonym: "down-regulation of juvenile hormone catabolic process" EXACT [] synonym: "downregulation of juvenile hormone catabolic process" EXACT [] synonym: "inhibition of juvenile hormone catabolic process" NARROW [] synonym: "negative regulation of juvenile hormone breakdown" EXACT [] synonym: "negative regulation of juvenile hormone catabolism" EXACT [] synonym: "negative regulation of juvenile hormone degradation" EXACT [] is_a: GO:0045928 ! negative regulation of juvenile hormone metabolic process is_a: GO:0045952 ! regulation of juvenile hormone catabolic process is_a: GO:0050995 ! negative regulation of lipid catabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0006719 ! negatively regulates juvenile hormone catabolic process relationship: RO:0002212 GO:0006719 ! negatively regulates juvenile hormone catabolic process property_value: RO:0002161 NCBITaxon:4895 [Term] id: GO:0045971 name: positive regulation of juvenile hormone catabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of juvenile hormone." [GOC:go_curators] synonym: "activation of juvenile hormone catabolic process" NARROW [] synonym: "positive regulation of juvenile hormone breakdown" EXACT [] synonym: "positive regulation of juvenile hormone catabolism" EXACT [] synonym: "positive regulation of juvenile hormone degradation" EXACT [] synonym: "stimulation of juvenile hormone catabolic process" NARROW [] synonym: "up regulation of juvenile hormone catabolic process" EXACT [] synonym: "up-regulation of juvenile hormone catabolic process" EXACT [] synonym: "upregulation of juvenile hormone catabolic process" EXACT [] is_a: GO:0032352 ! positive regulation of hormone metabolic process is_a: GO:0045952 ! regulation of juvenile hormone catabolic process is_a: GO:0050996 ! positive regulation of lipid catabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0006719 ! positively regulates juvenile hormone catabolic process relationship: RO:0002213 GO:0006719 ! positively regulates juvenile hormone catabolic process property_value: RO:0002161 NCBITaxon:4895 [Term] id: GO:0045972 name: negative regulation of juvenile hormone secretion namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of juvenile hormone." [GOC:go_curators] synonym: "down regulation of juvenile hormone secretion" EXACT [] synonym: "down-regulation of juvenile hormone secretion" EXACT [] synonym: "downregulation of juvenile hormone secretion" EXACT [] synonym: "inhibition of juvenile hormone secretion" NARROW [] is_a: GO:0007558 ! regulation of juvenile hormone secretion is_a: GO:0032369 ! negative regulation of lipid transport is_a: GO:0046888 ! negative regulation of hormone secretion is_a: GO:0051241 ! negative regulation of multicellular organismal process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0045443 ! negatively regulates juvenile hormone secretion relationship: RO:0002212 GO:0045443 ! negatively regulates juvenile hormone secretion property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0045973 name: positive regulation of juvenile hormone secretion namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the regulated release of juvenile hormone." [GOC:go_curators] synonym: "activation of juvenile hormone secretion" NARROW [] synonym: "stimulation of juvenile hormone secretion" NARROW [] synonym: "up regulation of juvenile hormone secretion" EXACT [] synonym: "up-regulation of juvenile hormone secretion" EXACT [] synonym: "upregulation of juvenile hormone secretion" EXACT [] is_a: GO:0007558 ! regulation of juvenile hormone secretion is_a: GO:0032370 ! positive regulation of lipid transport is_a: GO:0046887 ! positive regulation of hormone secretion intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0045443 ! positively regulates juvenile hormone secretion relationship: RO:0002213 GO:0045443 ! positively regulates juvenile hormone secretion property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0045980 name: negative regulation of nucleotide metabolic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving nucleotides." [GOC:go_curators] synonym: "down regulation of nucleotide metabolic process" EXACT [] synonym: "down-regulation of nucleotide metabolic process" EXACT [] synonym: "downregulation of nucleotide metabolic process" EXACT [] synonym: "inhibition of nucleotide metabolic process" NARROW [] synonym: "negative regulation of nucleotide metabolism" EXACT [] is_a: GO:0006140 ! regulation of nucleotide metabolic process is_a: GO:0045934 ! negative regulation of nucleobase-containing compound metabolic process is_a: GO:0045936 ! negative regulation of phosphate metabolic process is_a: GO:0062014 ! negative regulation of small molecule metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0009117 ! negatively regulates nucleotide metabolic process relationship: RO:0002212 GO:0009117 ! negatively regulates nucleotide metabolic process [Term] id: GO:0045981 name: positive regulation of nucleotide metabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving nucleotides." [GOC:go_curators] synonym: "activation of nucleotide metabolic process" NARROW [] synonym: "positive regulation of nucleotide metabolism" EXACT [] synonym: "stimulation of nucleotide metabolic process" NARROW [] synonym: "up regulation of nucleotide metabolic process" EXACT [] synonym: "up-regulation of nucleotide metabolic process" EXACT [] synonym: "upregulation of nucleotide metabolic process" EXACT [] is_a: GO:0006140 ! regulation of nucleotide metabolic process is_a: GO:0045937 ! positive regulation of phosphate metabolic process is_a: GO:0062013 ! positive regulation of small molecule metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0009117 ! positively regulates nucleotide metabolic process relationship: RO:0002213 GO:0009117 ! positively regulates nucleotide metabolic process [Term] id: GO:0045986 name: negative regulation of smooth muscle contraction namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of smooth muscle contraction." [GOC:go_curators] synonym: "down regulation of smooth muscle contraction" EXACT [] synonym: "down-regulation of smooth muscle contraction" EXACT [] synonym: "downregulation of smooth muscle contraction" EXACT [] synonym: "inhibition of smooth muscle contraction" NARROW [] synonym: "smooth muscle relaxation" RELATED [] is_a: GO:0006940 ! regulation of smooth muscle contraction is_a: GO:0045932 ! negative regulation of muscle contraction intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0006939 ! negatively regulates smooth muscle contraction relationship: RO:0002212 GO:0006939 ! negatively regulates smooth muscle contraction property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0045987 name: positive regulation of smooth muscle contraction namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of smooth muscle contraction." [GOC:go_curators] synonym: "activation of smooth muscle contraction" NARROW [] synonym: "stimulation of smooth muscle contraction" NARROW [] synonym: "up regulation of smooth muscle contraction" EXACT [] synonym: "up-regulation of smooth muscle contraction" EXACT [] synonym: "upregulation of smooth muscle contraction" EXACT [] is_a: GO:0006940 ! regulation of smooth muscle contraction is_a: GO:0045933 ! positive regulation of muscle contraction intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0006939 ! positively regulates smooth muscle contraction relationship: RO:0002213 GO:0006939 ! positively regulates smooth muscle contraction property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0045988 name: negative regulation of striated muscle contraction namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of striated muscle contraction." [GOC:go_curators] synonym: "down regulation of striated muscle contraction" EXACT [] synonym: "down-regulation of striated muscle contraction" EXACT [] synonym: "downregulation of striated muscle contraction" EXACT [] synonym: "inhibition of striated muscle contraction" NARROW [] is_a: GO:0006942 ! regulation of striated muscle contraction is_a: GO:0045932 ! negative regulation of muscle contraction intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0006941 ! negatively regulates striated muscle contraction relationship: RO:0002212 GO:0006941 ! negatively regulates striated muscle contraction property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0045989 name: positive regulation of striated muscle contraction namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of striated muscle contraction." [GOC:go_curators] synonym: "activation of striated muscle contraction" NARROW [] synonym: "stimulation of striated muscle contraction" NARROW [] synonym: "up regulation of striated muscle contraction" EXACT [] synonym: "up-regulation of striated muscle contraction" EXACT [] synonym: "upregulation of striated muscle contraction" EXACT [] is_a: GO:0006942 ! regulation of striated muscle contraction is_a: GO:0045933 ! positive regulation of muscle contraction intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0006941 ! positively regulates striated muscle contraction relationship: RO:0002213 GO:0006941 ! positively regulates striated muscle contraction property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0045992 name: negative regulation of embryonic development namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of embryonic development." [GOC:go_curators] synonym: "down regulation of embryonic development" EXACT [] synonym: "down-regulation of embryonic development" EXACT [] synonym: "downregulation of embryonic development" EXACT [] synonym: "inhibition of embryonic development" NARROW [] is_a: GO:0045995 ! regulation of embryonic development is_a: GO:0051093 ! negative regulation of developmental process is_a: GO:0051241 ! negative regulation of multicellular organismal process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0009790 ! negatively regulates embryo development relationship: RO:0002212 GO:0009790 ! negatively regulates embryo development property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0045995 name: regulation of embryonic development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of embryonic development." [GOC:go_curators] is_a: GO:2000026 ! regulation of multicellular organismal development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0009790 ! regulates embryo development relationship: RO:0002211 GO:0009790 ! regulates embryo development property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0045997 name: negative regulation of ecdysteroid biosynthetic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of ecdysteroids." [GOC:go_curators] synonym: "down regulation of ecdysteroid biosynthetic process" EXACT [] synonym: "down-regulation of ecdysteroid biosynthetic process" EXACT [] synonym: "downregulation of ecdysteroid biosynthetic process" EXACT [] synonym: "inhibition of ecdysteroid biosynthetic process" NARROW [] synonym: "negative regulation of ecdysteroid anabolism" EXACT [] synonym: "negative regulation of ecdysteroid biosynthesis" EXACT [] synonym: "negative regulation of ecdysteroid formation" EXACT [] synonym: "negative regulation of ecdysteroid synthesis" EXACT [] is_a: GO:0007554 ! regulation of ecdysteroid biosynthetic process is_a: GO:0062014 ! negative regulation of small molecule metabolic process is_a: GO:0090032 ! negative regulation of steroid hormone biosynthetic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0045456 ! negatively regulates ecdysteroid biosynthetic process relationship: RO:0002212 GO:0045456 ! negatively regulates ecdysteroid biosynthetic process [Term] id: GO:0045998 name: positive regulation of ecdysteroid biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of ecdysteroids." [GOC:go_curators] synonym: "activation of ecdysteroid biosynthetic process" NARROW [] synonym: "positive regulation of ecdysteroid anabolism" EXACT [] synonym: "positive regulation of ecdysteroid biosynthesis" EXACT [] synonym: "positive regulation of ecdysteroid formation" EXACT [] synonym: "positive regulation of ecdysteroid synthesis" EXACT [] synonym: "stimulation of ecdysteroid biosynthetic process" NARROW [] synonym: "up regulation of ecdysteroid biosynthetic process" EXACT [] synonym: "up-regulation of ecdysteroid biosynthetic process" EXACT [] synonym: "upregulation of ecdysteroid biosynthetic process" EXACT [] is_a: GO:0007554 ! regulation of ecdysteroid biosynthetic process is_a: GO:0062013 ! positive regulation of small molecule metabolic process is_a: GO:0090031 ! positive regulation of steroid hormone biosynthetic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0045456 ! positively regulates ecdysteroid biosynthetic process relationship: RO:0002213 GO:0045456 ! positively regulates ecdysteroid biosynthetic process [Term] id: GO:0045999 name: negative regulation of ecdysteroid secretion namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of ecdysteroid." [GOC:go_curators] synonym: "down regulation of ecdysteroid secretion" EXACT [] synonym: "down-regulation of ecdysteroid secretion" EXACT [] synonym: "downregulation of ecdysteroid secretion" EXACT [] synonym: "inhibition of ecdysteroid secretion" NARROW [] is_a: GO:0007555 ! regulation of ecdysteroid secretion is_a: GO:2000832 ! negative regulation of steroid hormone secretion intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0045457 ! negatively regulates ecdysteroid secretion relationship: RO:0002212 GO:0045457 ! negatively regulates ecdysteroid secretion property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0046000 name: positive regulation of ecdysteroid secretion namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the regulated release of ecdysteroid." [GOC:go_curators] synonym: "activation of ecdysteroid secretion" NARROW [] synonym: "stimulation of ecdysteroid secretion" NARROW [] synonym: "up regulation of ecdysteroid secretion" EXACT [] synonym: "up-regulation of ecdysteroid secretion" EXACT [] synonym: "upregulation of ecdysteroid secretion" EXACT [] is_a: GO:0007555 ! regulation of ecdysteroid secretion is_a: GO:2000833 ! positive regulation of steroid hormone secretion intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0045457 ! positively regulates ecdysteroid secretion relationship: RO:0002213 GO:0045457 ! positively regulates ecdysteroid secretion property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0046013 name: regulation of T cell homeostatic proliferation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of resting T cell proliferation." [GOC:go_curators] synonym: "regulation of resting T cell proliferation" EXACT [] synonym: "regulation of T lymphocyte homeostatic proliferation" EXACT [] synonym: "regulation of T-cell homeostatic proliferation" EXACT [] synonym: "regulation of T-lymphocyte homeostatic proliferation" EXACT [] is_a: GO:0042129 ! regulation of T cell proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0001777 ! regulates T cell homeostatic proliferation relationship: RO:0002211 GO:0001777 ! regulates T cell homeostatic proliferation [Term] id: GO:0046014 name: negative regulation of T cell homeostatic proliferation namespace: biological_process def: "Any process that stops, prevents or reduces the rate or extent of resting T cell proliferation." [GOC:go_curators] synonym: "down regulation of T cell homeostatic proliferation" EXACT [] synonym: "down-regulation of T cell homeostatic proliferation" EXACT [] synonym: "downregulation of T cell homeostatic proliferation" EXACT [] synonym: "inhibition of T cell homeostatic proliferation" NARROW [] synonym: "negative regulation of resting T cell proliferation" EXACT [] synonym: "negative regulation of T lymphocyte homeostatic proliferation" EXACT [] synonym: "negative regulation of T-cell homeostatic proliferation" EXACT [] synonym: "negative regulation of T-lymphocyte homeostatic proliferation" EXACT [] is_a: GO:0042130 ! negative regulation of T cell proliferation is_a: GO:0046013 ! regulation of T cell homeostatic proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0001777 ! negatively regulates T cell homeostatic proliferation relationship: RO:0002212 GO:0001777 ! negatively regulates T cell homeostatic proliferation [Term] id: GO:0046031 name: ADP metabolic process namespace: biological_process def: "The chemical reactions and pathways involving ADP, adenosine 5'-diphosphate." [GOC:go_curators] synonym: "ADP metabolism" EXACT [] is_a: GO:0009150 ! purine ribonucleotide metabolic process is_a: GO:0009179 ! purine ribonucleoside diphosphate metabolic process intersection_of: GO:0008152 ! metabolic process intersection_of: RO:0004007 CHEBI:456216 ! has primary input or output relationship: RO:0004007 CHEBI:456216 ! has primary input or output [Term] id: GO:0046032 name: ADP catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of ADP, adenosine 5'-diphosphate." [GOC:go_curators] synonym: "ADP breakdown" EXACT [] synonym: "ADP catabolism" EXACT [] synonym: "ADP degradation" EXACT [] is_a: GO:0009154 ! purine ribonucleotide catabolic process is_a: GO:0009181 ! purine ribonucleoside diphosphate catabolic process is_a: GO:0046031 ! ADP metabolic process intersection_of: GO:0009056 ! catabolic process intersection_of: RO:0004009 CHEBI:456216 ! has primary input relationship: RO:0004009 CHEBI:456216 ! has primary input [Term] id: GO:0046034 name: ATP metabolic process namespace: biological_process def: "The chemical reactions and pathways involving ATP, adenosine triphosphate, a universally important coenzyme and enzyme regulator." [GOC:go_curators] synonym: "ATP metabolism" EXACT [] is_a: GO:0009150 ! purine ribonucleotide metabolic process is_a: GO:0009205 ! purine ribonucleoside triphosphate metabolic process intersection_of: GO:0008152 ! metabolic process intersection_of: RO:0004007 CHEBI:30616 ! has primary input or output relationship: RO:0004007 CHEBI:30616 ! has primary input or output [Term] id: GO:0046148 name: pigment biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a pigment, any general or particular coloring matter in living organisms, e.g. melanin." [ISBN:0198506732] synonym: "pigment anabolism" EXACT [] synonym: "pigment biosynthesis" EXACT [] synonym: "pigment formation" EXACT [] synonym: "pigment synthesis" EXACT [] is_a: GO:0042440 ! pigment metabolic process [Term] id: GO:0046164 name: alcohol catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of alcohols, any of a class of compounds containing one or more hydroxyl groups attached to a saturated carbon atom." [GOC:ai] synonym: "alcohol breakdown" EXACT [] synonym: "alcohol catabolism" EXACT [] synonym: "alcohol degradation" EXACT [] is_a: GO:0006066 ! alcohol metabolic process is_a: GO:0044282 ! small molecule catabolic process intersection_of: GO:0009056 ! catabolic process intersection_of: RO:0004009 CHEBI:30879 ! has primary input relationship: RO:0004009 CHEBI:30879 ! has primary input [Term] id: GO:0046165 name: alcohol biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of alcohols, any of a class of compounds containing one or more hydroxyl groups attached to a saturated carbon atom." [GOC:ai] synonym: "alcohol anabolism" EXACT [] synonym: "alcohol biosynthesis" EXACT [] synonym: "alcohol formation" EXACT [] synonym: "alcohol synthesis" EXACT [] is_a: GO:0006066 ! alcohol metabolic process is_a: GO:0044283 ! small molecule biosynthetic process intersection_of: GO:0009058 ! biosynthetic process intersection_of: RO:0004008 CHEBI:30879 ! has primary output relationship: RO:0004008 CHEBI:30879 ! has primary output [Term] id: GO:0046184 name: aldehyde biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of aldehydes, any organic compound with the formula R-CH=O." [GOC:ai] synonym: "aldehyde anabolism" EXACT [] synonym: "aldehyde biosynthesis" EXACT [] synonym: "aldehyde formation" EXACT [] synonym: "aldehyde synthesis" EXACT [] is_a: GO:0006081 ! aldehyde metabolic process is_a: GO:0009058 ! biosynthetic process intersection_of: GO:0009058 ! biosynthetic process intersection_of: RO:0004008 CHEBI:17478 ! has primary output relationship: RO:0004008 CHEBI:17478 ! has primary output [Term] id: GO:0046185 name: aldehyde catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of aldehydes, any organic compound with the formula R-CH=O." [GOC:ai] synonym: "aldehyde breakdown" EXACT [] synonym: "aldehyde catabolism" EXACT [] synonym: "aldehyde degradation" EXACT [] is_a: GO:0006081 ! aldehyde metabolic process is_a: GO:0009056 ! catabolic process intersection_of: GO:0009056 ! catabolic process intersection_of: RO:0004009 CHEBI:17478 ! has primary input relationship: RO:0004009 CHEBI:17478 ! has primary input [Term] id: GO:0046189 name: phenol-containing compound biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a phenol, any compound containing one or more hydroxyl groups directly attached to an aromatic carbon ring." [GOC:ai] synonym: "phenol-containing compound anabolism" EXACT [] synonym: "phenol-containing compound biosynthesis" EXACT [] synonym: "phenol-containing compound formation" EXACT [] synonym: "phenol-containing compound synthesis" EXACT [] is_a: GO:0009058 ! biosynthetic process is_a: GO:0018958 ! phenol-containing compound metabolic process intersection_of: GO:0009058 ! biosynthetic process intersection_of: RO:0004008 CHEBI:33853 ! has primary output relationship: RO:0004008 CHEBI:33853 ! has primary output [Term] id: GO:0046209 name: nitric oxide metabolic process namespace: biological_process def: "The chemical reactions and pathways involving nitric oxide, nitrogen monoxide (NO), a colorless gas only slightly soluble in water." [GOC:ai] synonym: "nitric oxide metabolism" EXACT [] xref: Reactome:R-HSA-202131 "Metabolism of nitric oxide: NOS3 activation and regulation" is_a: GO:2001057 ! reactive nitrogen species metabolic process intersection_of: GO:0008152 ! metabolic process intersection_of: RO:0004007 CHEBI:16480 ! has primary input or output relationship: RO:0004007 CHEBI:16480 ! has primary input or output [Term] id: GO:0046210 name: nitric oxide catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of nitric oxide, nitrogen monoxide (NO), a colorless gas only slightly soluble in water." [GOC:ai] synonym: "nitric oxide breakdown" EXACT [] synonym: "nitric oxide catabolism" EXACT [] synonym: "nitric oxide degradation" EXACT [] is_a: GO:0009056 ! catabolic process is_a: GO:0046209 ! nitric oxide metabolic process intersection_of: GO:0009056 ! catabolic process intersection_of: RO:0004009 CHEBI:16480 ! has primary input relationship: RO:0004009 CHEBI:16480 ! has primary input [Term] id: GO:0046344 name: ecdysteroid catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of ecdysteroids, a group of polyhydroxylated ketosteroids which initiate post-embryonic development." [GOC:ai] synonym: "ecdysteroid breakdown" EXACT [] synonym: "ecdysteroid catabolism" EXACT [] synonym: "ecdysteroid degradation" EXACT [] is_a: GO:0006706 ! steroid catabolic process is_a: GO:0042182 ! ketone catabolic process is_a: GO:0042447 ! hormone catabolic process is_a: GO:0045455 ! ecdysteroid metabolic process intersection_of: GO:0009056 ! catabolic process intersection_of: RO:0004009 CHEBI:23897 ! has primary input relationship: RO:0004009 CHEBI:23897 ! has primary input [Term] id: GO:0046364 name: monosaccharide biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of monosaccharides, polyhydric alcohols containing either an aldehyde or a keto group and between three to ten or more carbon atoms." [ISBN:0198506732] synonym: "monosaccharide anabolism" EXACT [] synonym: "monosaccharide biosynthesis" EXACT [] synonym: "monosaccharide formation" EXACT [] synonym: "monosaccharide synthesis" EXACT [] is_a: GO:0005996 ! monosaccharide metabolic process is_a: GO:0016051 ! carbohydrate biosynthetic process is_a: GO:0044283 ! small molecule biosynthetic process intersection_of: GO:0009058 ! biosynthetic process intersection_of: RO:0004008 CHEBI:35381 ! has primary output relationship: RO:0004008 CHEBI:35381 ! has primary output [Term] id: GO:0046365 name: monosaccharide catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of monosaccharides, polyhydric alcohols containing either an aldehyde or a keto group and between three to ten or more carbon atoms." [ISBN:0198506732] synonym: "monosaccharide breakdown" EXACT [] synonym: "monosaccharide catabolism" EXACT [] synonym: "monosaccharide degradation" EXACT [] is_a: GO:0005996 ! monosaccharide metabolic process is_a: GO:0016052 ! carbohydrate catabolic process is_a: GO:0044282 ! small molecule catabolic process intersection_of: GO:0009056 ! catabolic process intersection_of: RO:0004009 CHEBI:35381 ! has primary input relationship: RO:0004009 CHEBI:35381 ! has primary input [Term] id: GO:0046390 name: ribose phosphate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of ribose phosphate, any phosphorylated ribose sugar." [GOC:ai] synonym: "ribose phosphate anabolism" EXACT [] synonym: "ribose phosphate biosynthesis" EXACT [] synonym: "ribose phosphate formation" EXACT [] synonym: "ribose phosphate synthesis" EXACT [] is_a: GO:0019693 ! ribose phosphate metabolic process is_a: GO:0090407 ! organophosphate biosynthetic process is_a: GO:1901137 ! carbohydrate derivative biosynthetic process intersection_of: GO:0009058 ! biosynthetic process intersection_of: RO:0004008 CHEBI:26562 ! has primary output relationship: RO:0004008 CHEBI:26562 ! has primary output [Term] id: GO:0046394 name: carboxylic acid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of carboxylic acids, any organic acid containing one or more carboxyl (-COOH) groups." [ISBN:0198506732] synonym: "carboxylic acid anabolism" EXACT [] synonym: "carboxylic acid biosynthesis" EXACT [] synonym: "carboxylic acid formation" EXACT [] synonym: "carboxylic acid synthesis" EXACT [] is_a: GO:0016053 ! organic acid biosynthetic process is_a: GO:0019752 ! carboxylic acid metabolic process intersection_of: GO:0009058 ! biosynthetic process intersection_of: RO:0004008 CHEBI:29067 ! has primary output relationship: RO:0004008 CHEBI:29067 ! has primary output [Term] id: GO:0046395 name: carboxylic acid catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of carboxylic acids, any organic acid containing one or more carboxyl (-COOH) groups." [ISBN:0198506732] synonym: "carboxylic acid breakdown" EXACT [] synonym: "carboxylic acid catabolism" EXACT [] synonym: "carboxylic acid degradation" EXACT [] is_a: GO:0016054 ! organic acid catabolic process is_a: GO:0019752 ! carboxylic acid metabolic process intersection_of: GO:0009056 ! catabolic process intersection_of: RO:0004009 CHEBI:29067 ! has primary input relationship: RO:0004009 CHEBI:29067 ! has primary input [Term] id: GO:0046434 name: organophosphate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of organophosphates, any phosphate-containing organic compound." [GOC:ai] synonym: "organophosphate breakdown" EXACT [] synonym: "organophosphate catabolism" EXACT [] synonym: "organophosphate degradation" EXACT [] is_a: GO:0009056 ! catabolic process is_a: GO:0019637 ! organophosphate metabolic process intersection_of: GO:0009056 ! catabolic process intersection_of: RO:0004009 CHEBI:25710 ! has primary input relationship: RO:0004009 CHEBI:25710 ! has primary input [Term] id: GO:0046459 name: short-chain fatty acid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a short-chain fatty acid. A short-chain fatty acid has an aliphatic tail containing fewer than 6 carbons." [Wikipedia:Fatty_acid_metabolism] comment: While there is not universal consensus on the lengths of short-, medium-, long- and very-long-chain fatty acids, the GO uses the definitions in ChEBI (see CHEBI:26666, CHEBI:59554, CHEBI:15904 and CHEBI:27283). synonym: "short-chain fatty acid metabolism" EXACT [] is_a: GO:0006631 ! fatty acid metabolic process intersection_of: GO:0008152 ! metabolic process intersection_of: RO:0004007 CHEBI:58951 ! has primary input or output relationship: RO:0004007 CHEBI:58951 ! has primary input or output property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/26445" xsd:anyURI [Term] id: GO:0046466 name: membrane lipid catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of membrane lipids, any lipid found in or associated with a biological membrane." [GOC:ai] synonym: "membrane lipid breakdown" EXACT [] synonym: "membrane lipid catabolism" EXACT [] synonym: "membrane lipid degradation" EXACT [] synonym: "membrane lipid peroxidation" BROAD [GOC:tb] is_a: GO:0006643 ! membrane lipid metabolic process is_a: GO:0016042 ! lipid catabolic process intersection_of: GO:0009056 ! catabolic process intersection_of: BFO:0000066 GO:0016020 ! occurs in membrane intersection_of: RO:0004009 CHEBI:18059 ! has primary input property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/28908" xsd:anyURI [Term] id: GO:0046467 name: membrane lipid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of membrane lipids, any lipid found in or associated with a biological membrane." [GOC:ai] synonym: "membrane lipid anabolism" EXACT [] synonym: "membrane lipid biosynthesis" EXACT [] synonym: "membrane lipid formation" EXACT [] synonym: "membrane lipid synthesis" EXACT [] is_a: GO:0006643 ! membrane lipid metabolic process is_a: GO:0008610 ! lipid biosynthetic process intersection_of: GO:0009058 ! biosynthetic process intersection_of: BFO:0000066 GO:0016020 ! occurs in membrane intersection_of: RO:0004008 CHEBI:18059 ! has primary output [Term] id: GO:0046479 name: glycosphingolipid catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of glycosphingolipid, a compound with residues of sphingoid and at least one monosaccharide." [ISBN:0198506732] synonym: "glycosphingolipid breakdown" EXACT [] synonym: "glycosphingolipid catabolism" EXACT [] synonym: "glycosphingolipid degradation" EXACT [] xref: Reactome:R-HSA-9840310 "Glycosphingolipid catabolism" is_a: GO:0006687 ! glycosphingolipid metabolic process is_a: GO:0019377 ! glycolipid catabolic process is_a: GO:0030149 ! sphingolipid catabolic process intersection_of: GO:0009056 ! catabolic process intersection_of: RO:0004009 CHEBI:24402 ! has primary input relationship: RO:0004009 CHEBI:24402 ! has primary input [Term] id: GO:0046530 name: photoreceptor cell differentiation namespace: biological_process def: "The specialization of organization of a photoreceptor, a cell that responds to incident electromagnetic radiation, particularly visible light. An example of this process is found in Drosophila melanogaster." [GOC:ai, ISBN:0198506732] is_a: GO:0030182 ! neuron differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000210 ! results in acquisition of features of photoreceptor cell relationship: RO:0002315 CL:0000210 ! results in acquisition of features of photoreceptor cell [Term] id: GO:0046532 name: regulation of photoreceptor cell differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of photoreceptor cell differentiation. An example of this process is found in Drosophila melanogaster." [GOC:go_curators] synonym: "regulation of photoreceptor differentiation" EXACT [] is_a: GO:0045664 ! regulation of neuron differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0046530 ! regulates photoreceptor cell differentiation relationship: RO:0002211 GO:0046530 ! regulates photoreceptor cell differentiation [Term] id: GO:0046533 name: negative regulation of photoreceptor cell differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of photoreceptor cell differentiation. An example of this process is found in Drosophila melanogaster." [GOC:go_curators] synonym: "down regulation of photoreceptor cell differentiation" EXACT [] synonym: "down regulation of photoreceptor differentiation" EXACT [] synonym: "down-regulation of photoreceptor cell differentiation" EXACT [] synonym: "down-regulation of photoreceptor differentiation" EXACT [] synonym: "downregulation of photoreceptor cell differentiation" EXACT [] synonym: "downregulation of photoreceptor differentiation" EXACT [] synonym: "inhibition of photoreceptor cell differentiation" NARROW [] synonym: "inhibition of photoreceptor differentiation" NARROW [] synonym: "negative regulation of photoreceptor differentiation" EXACT [] is_a: GO:0045665 ! negative regulation of neuron differentiation is_a: GO:0046532 ! regulation of photoreceptor cell differentiation is_a: GO:0051241 ! negative regulation of multicellular organismal process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0046530 ! negatively regulates photoreceptor cell differentiation relationship: RO:0002212 GO:0046530 ! negatively regulates photoreceptor cell differentiation [Term] id: GO:0046534 name: positive regulation of photoreceptor cell differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of photoreceptor cell differentiation. An example of this process is found in Drosophila melanogaster." [GOC:go_curators] synonym: "activation of photoreceptor cell differentiation" NARROW [] synonym: "activation of photoreceptor differentiation" NARROW [] synonym: "positive regulation of photoreceptor differentiation" EXACT [] synonym: "stimulation of photoreceptor cell differentiation" NARROW [] synonym: "stimulation of photoreceptor differentiation" NARROW [] synonym: "up regulation of photoreceptor cell differentiation" EXACT [] synonym: "up regulation of photoreceptor differentiation" EXACT [] synonym: "up-regulation of photoreceptor cell differentiation" EXACT [] synonym: "up-regulation of photoreceptor differentiation" EXACT [] synonym: "upregulation of photoreceptor cell differentiation" EXACT [] synonym: "upregulation of photoreceptor differentiation" EXACT [] is_a: GO:0045666 ! positive regulation of neuron differentiation is_a: GO:0046532 ! regulation of photoreceptor cell differentiation is_a: GO:0051240 ! positive regulation of multicellular organismal process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0046530 ! positively regulates photoreceptor cell differentiation relationship: RO:0002213 GO:0046530 ! positively regulates photoreceptor cell differentiation [Term] id: GO:0046541 name: saliva secretion namespace: biological_process def: "The regulated release of saliva from the salivary glands. In man, the saliva is a turbid and slightly viscous fluid, generally of an alkaline reaction, and is secreted by the parotid, submaxillary, and sublingual glands. In the mouth the saliva is mixed with the secretion from the buccal glands. In man and many animals, saliva is an important digestive fluid on account of the presence of the peculiar enzyme, ptyalin." [GOC:curators, UBERON:0001836] synonym: "salivation" EXACT [] xref: Wikipedia:Salivation is_a: GO:0007589 ! body fluid secretion is_a: GO:0022600 ! digestive system process is_a: GO:0032941 ! secretion by tissue property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0046545 name: development of primary female sexual characteristics namespace: biological_process def: "The process whose specific outcome is the progression of the primary female sexual characteristics over time, from their formation to the mature structure. The primary female sexual characteristics are the ovaries, and they develop in response to sex hormone secretion." [GOC:ai] is_a: GO:0045137 ! development of primary sexual characteristics relationship: BFO:0000050 GO:0046660 ! part of female sex differentiation property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0046546 name: development of primary male sexual characteristics namespace: biological_process def: "The process whose specific outcome is the progression of the primary male sexual characteristics over time, from their formation to the mature structures. The primary male sexual characteristics are the testes, and they develop in response to sex hormone secretion." [GOC:ai] is_a: GO:0045137 ! development of primary sexual characteristics relationship: BFO:0000050 GO:0046661 ! part of male sex differentiation property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0046548 name: retinal rod cell development namespace: biological_process def: "Development of a rod cell, one of the sensory cells in the eye that reacts to the presence of light. Rod cells contain the photopigment rhodopsin or porphyropsin and are responsible for vision in dim light." [ISBN:0198506732] is_a: GO:0042462 ! eye photoreceptor cell development intersection_of: GO:0032502 ! developmental process intersection_of: RO:0002296 CL:0000604 ! results in development of retinal rod cell relationship: BFO:0000050 GO:0060221 ! part of retinal rod cell differentiation relationship: RO:0002296 CL:0000604 ! results in development of retinal rod cell [Term] id: GO:0046549 name: retinal cone cell development namespace: biological_process def: "Development of a cone cell, one of the sensory cells in the eye that reacts to the presence of light. Cone cells contain the photopigment iodopsin or cyanopsin and are responsible for photopic (daylight) vision." [ISBN:0198506732] is_a: GO:0042462 ! eye photoreceptor cell development intersection_of: GO:0032502 ! developmental process intersection_of: RO:0002296 CL:0000573 ! results in development of retinal cone cell relationship: BFO:0000050 GO:0042670 ! part of retinal cone cell differentiation relationship: RO:0002296 CL:0000573 ! results in development of retinal cone cell [Term] id: GO:0046620 name: regulation of organ growth namespace: biological_process def: "Any process that modulates the frequency, rate or extent of growth of an organ of an organism." [GOC:bf, GOC:tb] is_a: GO:0048638 ! regulation of developmental growth is_a: GO:0051239 ! regulation of multicellular organismal process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0035265 ! regulates organ growth relationship: RO:0002211 GO:0035265 ! regulates organ growth property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0046621 name: negative regulation of organ growth namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of growth of an organ of an organism." [GOC:bf, GOC:tb] is_a: GO:0046620 ! regulation of organ growth is_a: GO:0048640 ! negative regulation of developmental growth is_a: GO:0051241 ! negative regulation of multicellular organismal process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0035265 ! negatively regulates organ growth relationship: RO:0002212 GO:0035265 ! negatively regulates organ growth property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0046622 name: positive regulation of organ growth namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of growth of an organ of an organism." [GOC:bf, GOC:tb] is_a: GO:0046620 ! regulation of organ growth is_a: GO:0048639 ! positive regulation of developmental growth is_a: GO:0051240 ! positive regulation of multicellular organismal process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0035265 ! positively regulates organ growth relationship: RO:0002213 GO:0035265 ! positively regulates organ growth property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0046624 name: sphingolipid transporter activity namespace: molecular_function def: "Enables the directed movement of sphingolipids into, out of or within a cell, or between cells. Sphingolipids are a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid)." [GOC:ai, ISBN:0198506732] xref: Reactome:R-HSA-9695890 "SPNS2,MFSD2B transport S1P from cytosol to extracellular region" xref: Reactome:R-HSA-9843721 "ABCC1,ABCG2 transport C18-S1P to extracellular region" is_a: GO:0005319 ! lipid transporter activity intersection_of: GO:0005215 ! transporter activity intersection_of: RO:0004009 CHEBI:26739 ! has primary input relationship: RO:0004009 CHEBI:26739 ! has primary input [Term] id: GO:0046625 name: sphingolipid binding namespace: molecular_function def: "Binding to a sphingolipid, a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid)." [ISBN:0198506732] is_a: GO:0008289 ! lipid binding intersection_of: GO:0005488 ! binding intersection_of: RO:0004009 CHEBI:26739 ! has primary input relationship: RO:0004009 CHEBI:26739 ! has primary input [Term] id: GO:0046626 name: regulation of insulin receptor signaling pathway namespace: biological_process def: "Any process that modulates the frequency, rate or extent of insulin receptor signaling." [GOC:bf] synonym: "regulation of insulin receptor signalling pathway" EXACT [] is_a: GO:0009966 ! regulation of signal transduction intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0008286 ! regulates insulin receptor signaling pathway relationship: RO:0002211 GO:0008286 ! regulates insulin receptor signaling pathway [Term] id: GO:0046627 name: negative regulation of insulin receptor signaling pathway namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of insulin receptor signaling." [GOC:bf] synonym: "down regulation of insulin receptor signaling pathway" EXACT [] synonym: "down-regulation of insulin receptor signaling pathway" EXACT [] synonym: "downregulation of insulin receptor signaling pathway" EXACT [] synonym: "inhibition of insulin receptor signaling pathway" NARROW [] synonym: "negative regulation of insulin receptor signalling pathway" EXACT [] is_a: GO:0009968 ! negative regulation of signal transduction is_a: GO:0046626 ! regulation of insulin receptor signaling pathway is_a: GO:1900077 ! negative regulation of cellular response to insulin stimulus intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0008286 ! negatively regulates insulin receptor signaling pathway relationship: RO:0002212 GO:0008286 ! negatively regulates insulin receptor signaling pathway [Term] id: GO:0046628 name: positive regulation of insulin receptor signaling pathway namespace: biological_process def: "Any process that increases the frequency, rate or extent of insulin receptor signaling." [GOC:bf] synonym: "activation of insulin receptor signaling pathway" NARROW [] synonym: "positive regulation of insulin receptor signalling pathway" EXACT [] synonym: "stimulation of insulin receptor signaling pathway" NARROW [] synonym: "up regulation of insulin receptor signaling pathway" EXACT [] synonym: "up-regulation of insulin receptor signaling pathway" EXACT [] synonym: "upregulation of insulin receptor signaling pathway" EXACT [] is_a: GO:0009967 ! positive regulation of signal transduction is_a: GO:0046626 ! regulation of insulin receptor signaling pathway is_a: GO:1900078 ! positive regulation of cellular response to insulin stimulus intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0008286 ! positively regulates insulin receptor signaling pathway relationship: RO:0002213 GO:0008286 ! positively regulates insulin receptor signaling pathway [Term] id: GO:0046629 name: gamma-delta T cell activation namespace: biological_process def: "The change in morphology and behavior of a gamma-delta T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific." [GOC:add] synonym: "gamma-delta T lymphocyte activation" EXACT [] synonym: "gamma-delta T-cell activation" EXACT [] synonym: "gamma-delta T-lymphocyte activation" EXACT [] is_a: GO:0042110 ! T cell activation intersection_of: GO:0001775 ! cell activation intersection_of: RO:0004009 CL:0000798 ! has primary input gamma-delta T cell relationship: RO:0004009 CL:0000798 ! has primary input gamma-delta T cell [Term] id: GO:0046630 name: gamma-delta T cell proliferation namespace: biological_process def: "The expansion of a gamma-delta T cell population by cell division." [GOC:ai] synonym: "gamma-delta T lymphocyte proliferation" EXACT [] synonym: "gamma-delta T-cell proliferation" EXACT [] synonym: "gamma-delta T-lymphocyte proliferation" EXACT [] is_a: GO:0042098 ! T cell proliferation is_a: GO:0046629 ! gamma-delta T cell activation intersection_of: GO:0008283 ! cell population proliferation intersection_of: RO:0012003 CL:0000798 ! acts on population of gamma-delta T cell relationship: RO:0012003 CL:0000798 ! acts on population of gamma-delta T cell [Term] id: GO:0046631 name: alpha-beta T cell activation namespace: biological_process def: "The change in morphology and behavior of an alpha-beta T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific." [GOC:add] synonym: "alpha-beta T lymphocyte activation" EXACT [] synonym: "alpha-beta T-cell activation" EXACT [] synonym: "alpha-beta T-lymphocyte activation" EXACT [] is_a: GO:0042110 ! T cell activation intersection_of: GO:0001775 ! cell activation intersection_of: RO:0004009 CL:0000789 ! has primary input alpha-beta T cell relationship: RO:0004009 CL:0000789 ! has primary input alpha-beta T cell [Term] id: GO:0046632 name: alpha-beta T cell differentiation namespace: biological_process def: "The process in which a precursor cell type acquires the specialized features of an alpha-beta T cell. An alpha-beta T cell is a T cell that expresses an alpha-beta T cell receptor complex." [CL:0000789, GOC:ai] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "alpha-beta T cell development" RELATED [GOC:add] synonym: "alpha-beta T lymphocyte differentiation" EXACT [] synonym: "alpha-beta T-cell differentiation" EXACT [] synonym: "alpha-beta T-lymphocyte differentiation" EXACT [] is_a: GO:0030217 ! T cell differentiation is_a: GO:0046631 ! alpha-beta T cell activation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000789 ! results in acquisition of features of alpha-beta T cell relationship: RO:0002315 CL:0000789 ! results in acquisition of features of alpha-beta T cell [Term] id: GO:0046633 name: alpha-beta T cell proliferation namespace: biological_process def: "The expansion of an alpha-beta T cell population by cell division." [GOC:ai] synonym: "alpha-beta T lymphocyte proliferation" EXACT [] synonym: "alpha-beta T-cell proliferation" EXACT [] synonym: "alpha-beta T-lymphocyte proliferation" EXACT [] is_a: GO:0042098 ! T cell proliferation is_a: GO:0046631 ! alpha-beta T cell activation intersection_of: GO:0008283 ! cell population proliferation intersection_of: RO:0012003 CL:0000789 ! acts on population of alpha-beta T cell relationship: RO:0012003 CL:0000789 ! acts on population of alpha-beta T cell [Term] id: GO:0046634 name: regulation of alpha-beta T cell activation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of alpha-beta T cell activation." [GOC:ai] synonym: "regulation of alpha-beta T lymphocyte activation" EXACT [] synonym: "regulation of alpha-beta T-cell activation" EXACT [] synonym: "regulation of alpha-beta T-lymphocyte activation" EXACT [] is_a: GO:0050863 ! regulation of T cell activation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0046631 ! regulates alpha-beta T cell activation relationship: RO:0002211 GO:0046631 ! regulates alpha-beta T cell activation [Term] id: GO:0046635 name: positive regulation of alpha-beta T cell activation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of alpha-beta T cell activation." [GOC:ai] synonym: "activation of alpha-beta T cell activation" NARROW [] synonym: "positive regulation of alpha-beta T lymphocyte activation" EXACT [] synonym: "positive regulation of alpha-beta T-cell activation" EXACT [] synonym: "positive regulation of alpha-beta T-lymphocyte activation" EXACT [] synonym: "stimulation of alpha-beta T cell activation" NARROW [] synonym: "up regulation of alpha-beta T cell activation" EXACT [] synonym: "up-regulation of alpha-beta T cell activation" EXACT [] synonym: "upregulation of alpha-beta T cell activation" EXACT [] is_a: GO:0046634 ! regulation of alpha-beta T cell activation is_a: GO:0050870 ! positive regulation of T cell activation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0046631 ! positively regulates alpha-beta T cell activation relationship: RO:0002213 GO:0046631 ! positively regulates alpha-beta T cell activation [Term] id: GO:0046636 name: negative regulation of alpha-beta T cell activation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of alpha-beta T cell activation." [GOC:ai] synonym: "down regulation of alpha-beta T cell activation" EXACT [] synonym: "down-regulation of alpha-beta T cell activation" EXACT [] synonym: "downregulation of alpha-beta T cell activation" EXACT [] synonym: "inhibition of alpha-beta T cell activation" NARROW [] synonym: "negative regulation of alpha-beta T lymphocyte activation" EXACT [] synonym: "negative regulation of alpha-beta T-cell activation" EXACT [] synonym: "negative regulation of alpha-beta T-lymphocyte activation" EXACT [] is_a: GO:0046634 ! regulation of alpha-beta T cell activation is_a: GO:0050868 ! negative regulation of T cell activation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0046631 ! negatively regulates alpha-beta T cell activation relationship: RO:0002212 GO:0046631 ! negatively regulates alpha-beta T cell activation [Term] id: GO:0046637 name: regulation of alpha-beta T cell differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of alpha-beta T cell differentiation." [GOC:ai] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "regulation of alpha-beta T cell development" RELATED [GOC:add] synonym: "regulation of alpha-beta T lymphocyte differentiation" EXACT [] synonym: "regulation of alpha-beta T-cell differentiation" EXACT [] synonym: "regulation of alpha-beta T-lymphocyte differentiation" EXACT [] is_a: GO:0045580 ! regulation of T cell differentiation is_a: GO:0046634 ! regulation of alpha-beta T cell activation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0046632 ! regulates alpha-beta T cell differentiation relationship: RO:0002211 GO:0046632 ! regulates alpha-beta T cell differentiation [Term] id: GO:0046638 name: positive regulation of alpha-beta T cell differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of alpha-beta T cell differentiation." [GOC:ai] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "activation of alpha-beta T cell differentiation" NARROW [] synonym: "positive regulation of alpha-beta T cell development" RELATED [GOC:add] synonym: "positive regulation of alpha-beta T lymphocyte differentiation" EXACT [] synonym: "positive regulation of alpha-beta T-cell differentiation" EXACT [] synonym: "positive regulation of alpha-beta T-lymphocyte differentiation" EXACT [] synonym: "stimulation of alpha-beta T cell differentiation" NARROW [] synonym: "up regulation of alpha-beta T cell differentiation" EXACT [] synonym: "up-regulation of alpha-beta T cell differentiation" EXACT [] synonym: "upregulation of alpha-beta T cell differentiation" EXACT [] is_a: GO:0045582 ! positive regulation of T cell differentiation is_a: GO:0046635 ! positive regulation of alpha-beta T cell activation is_a: GO:0046637 ! regulation of alpha-beta T cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0046632 ! positively regulates alpha-beta T cell differentiation relationship: RO:0002213 GO:0046632 ! positively regulates alpha-beta T cell differentiation [Term] id: GO:0046639 name: negative regulation of alpha-beta T cell differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of alpha-beta T cell differentiation." [GOC:ai] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "down regulation of alpha-beta T cell differentiation" EXACT [] synonym: "down-regulation of alpha-beta T cell differentiation" EXACT [] synonym: "downregulation of alpha-beta T cell differentiation" EXACT [] synonym: "inhibition of alpha-beta T cell differentiation" NARROW [] synonym: "negative regulation of alpha-beta T cell development" RELATED [GOC:add] synonym: "negative regulation of alpha-beta T lymphocyte differentiation" EXACT [] synonym: "negative regulation of alpha-beta T-cell differentiation" EXACT [] synonym: "negative regulation of alpha-beta T-lymphocyte differentiation" EXACT [] is_a: GO:0045581 ! negative regulation of T cell differentiation is_a: GO:0046636 ! negative regulation of alpha-beta T cell activation is_a: GO:0046637 ! regulation of alpha-beta T cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0046632 ! negatively regulates alpha-beta T cell differentiation relationship: RO:0002212 GO:0046632 ! negatively regulates alpha-beta T cell differentiation [Term] id: GO:0046640 name: regulation of alpha-beta T cell proliferation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of alpha-beta T cell proliferation." [GOC:ai] synonym: "regulation of alpha-beta T lymphocyte proliferation" EXACT [] synonym: "regulation of alpha-beta T-cell proliferation" EXACT [] synonym: "regulation of alpha-beta T-lymphocyte proliferation" EXACT [] is_a: GO:0042129 ! regulation of T cell proliferation is_a: GO:0046634 ! regulation of alpha-beta T cell activation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0046633 ! regulates alpha-beta T cell proliferation relationship: RO:0002211 GO:0046633 ! regulates alpha-beta T cell proliferation [Term] id: GO:0046641 name: positive regulation of alpha-beta T cell proliferation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of alpha-beta T cell proliferation." [GOC:ai] synonym: "activation of alpha-beta T cell proliferation" NARROW [] synonym: "positive regulation of alpha-beta T lymphocyte proliferation" EXACT [] synonym: "positive regulation of alpha-beta T-cell proliferation" EXACT [] synonym: "positive regulation of alpha-beta T-lymphocyte proliferation" EXACT [] synonym: "stimulation of alpha-beta T cell proliferation" NARROW [] synonym: "up regulation of alpha-beta T cell proliferation" EXACT [] synonym: "up-regulation of alpha-beta T cell proliferation" EXACT [] synonym: "upregulation of alpha-beta T cell proliferation" EXACT [] is_a: GO:0042102 ! positive regulation of T cell proliferation is_a: GO:0046635 ! positive regulation of alpha-beta T cell activation is_a: GO:0046640 ! regulation of alpha-beta T cell proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0046633 ! positively regulates alpha-beta T cell proliferation relationship: RO:0002213 GO:0046633 ! positively regulates alpha-beta T cell proliferation [Term] id: GO:0046642 name: negative regulation of alpha-beta T cell proliferation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of alpha-beta T cell proliferation." [GOC:ai] synonym: "down regulation of alpha-beta T cell proliferation" EXACT [] synonym: "down-regulation of alpha-beta T cell proliferation" EXACT [] synonym: "downregulation of alpha-beta T cell proliferation" EXACT [] synonym: "inhibition of alpha-beta T cell proliferation" NARROW [] synonym: "negative regulation of alpha-beta T lymphocyte proliferation" EXACT [] synonym: "negative regulation of alpha-beta T-cell proliferation" EXACT [] synonym: "negative regulation of alpha-beta T-lymphocyte proliferation" EXACT [] is_a: GO:0042130 ! negative regulation of T cell proliferation is_a: GO:0046636 ! negative regulation of alpha-beta T cell activation is_a: GO:0046640 ! regulation of alpha-beta T cell proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0046633 ! negatively regulates alpha-beta T cell proliferation relationship: RO:0002212 GO:0046633 ! negatively regulates alpha-beta T cell proliferation [Term] id: GO:0046643 name: regulation of gamma-delta T cell activation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of gamma-delta T cell activation." [GOC:ai] synonym: "regulation of gamma-delta T lymphocyte activation" EXACT [] synonym: "regulation of gamma-delta T-cell activation" EXACT [] synonym: "regulation of gamma-delta T-lymphocyte activation" EXACT [] is_a: GO:0050863 ! regulation of T cell activation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0046629 ! regulates gamma-delta T cell activation relationship: RO:0002211 GO:0046629 ! regulates gamma-delta T cell activation [Term] id: GO:0046644 name: negative regulation of gamma-delta T cell activation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of gamma-delta T cell activation." [GOC:ai] synonym: "down regulation of gamma-delta T cell activation" EXACT [] synonym: "down-regulation of gamma-delta T cell activation" EXACT [] synonym: "downregulation of gamma-delta T cell activation" EXACT [] synonym: "inhibition of gamma-delta T cell activation" NARROW [] synonym: "negative regulation of gamma-delta T lymphocyte activation" EXACT [] synonym: "negative regulation of gamma-delta T-cell activation" EXACT [] synonym: "negative regulation of gamma-delta T-lymphocyte activation" EXACT [] is_a: GO:0046643 ! regulation of gamma-delta T cell activation is_a: GO:0050868 ! negative regulation of T cell activation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0046629 ! negatively regulates gamma-delta T cell activation relationship: RO:0002212 GO:0046629 ! negatively regulates gamma-delta T cell activation [Term] id: GO:0046645 name: positive regulation of gamma-delta T cell activation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of gamma-delta T cell activation." [GOC:ai] synonym: "activation of gamma-delta T cell activation" NARROW [] synonym: "positive regulation of gamma-delta T lymphocyte activation" EXACT [] synonym: "positive regulation of gamma-delta T-cell activation" EXACT [] synonym: "positive regulation of gamma-delta T-lymphocyte activation" EXACT [] synonym: "stimulation of gamma-delta T cell activation" NARROW [] synonym: "up regulation of gamma-delta T cell activation" EXACT [] synonym: "up-regulation of gamma-delta T cell activation" EXACT [] synonym: "upregulation of gamma-delta T cell activation" EXACT [] is_a: GO:0046643 ! regulation of gamma-delta T cell activation is_a: GO:0050870 ! positive regulation of T cell activation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0046629 ! positively regulates gamma-delta T cell activation relationship: RO:0002213 GO:0046629 ! positively regulates gamma-delta T cell activation [Term] id: GO:0046646 name: regulation of gamma-delta T cell proliferation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of gamma-delta T cell proliferation." [GOC:ai] synonym: "regulation of gamma-delta T lymphocyte proliferation" EXACT [] synonym: "regulation of gamma-delta T-cell proliferation" EXACT [] synonym: "regulation of gamma-delta T-lymphocyte proliferation" EXACT [] is_a: GO:0042129 ! regulation of T cell proliferation is_a: GO:0046643 ! regulation of gamma-delta T cell activation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0046630 ! regulates gamma-delta T cell proliferation relationship: RO:0002211 GO:0046630 ! regulates gamma-delta T cell proliferation [Term] id: GO:0046647 name: negative regulation of gamma-delta T cell proliferation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of gamma-delta T cell proliferation." [GOC:ai] synonym: "down regulation of gamma-delta T cell proliferation" EXACT [] synonym: "down-regulation of gamma-delta T cell proliferation" EXACT [] synonym: "downregulation of gamma-delta T cell proliferation" EXACT [] synonym: "inhibition of gamma-delta T cell proliferation" NARROW [] synonym: "negative regulation of gamma-delta T lymphocyte proliferation" EXACT [] synonym: "negative regulation of gamma-delta T-cell proliferation" EXACT [] synonym: "negative regulation of gamma-delta T-lymphocyte proliferation" EXACT [] is_a: GO:0042130 ! negative regulation of T cell proliferation is_a: GO:0046644 ! negative regulation of gamma-delta T cell activation is_a: GO:0046646 ! regulation of gamma-delta T cell proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0046630 ! negatively regulates gamma-delta T cell proliferation relationship: RO:0002212 GO:0046630 ! negatively regulates gamma-delta T cell proliferation [Term] id: GO:0046648 name: positive regulation of gamma-delta T cell proliferation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of gamma-delta T cell proliferation." [GOC:ai] synonym: "activation of gamma-delta T cell proliferation" NARROW [] synonym: "positive regulation of gamma-delta T lymphocyte proliferation" EXACT [] synonym: "positive regulation of gamma-delta T-cell proliferation" EXACT [] synonym: "positive regulation of gamma-delta T-lymphocyte proliferation" EXACT [] synonym: "stimulation of gamma-delta T cell proliferation" NARROW [] synonym: "up regulation of gamma-delta T cell proliferation" EXACT [] synonym: "up-regulation of gamma-delta T cell proliferation" EXACT [] synonym: "upregulation of gamma-delta T cell proliferation" EXACT [] is_a: GO:0042102 ! positive regulation of T cell proliferation is_a: GO:0046645 ! positive regulation of gamma-delta T cell activation is_a: GO:0046646 ! regulation of gamma-delta T cell proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0046630 ! positively regulates gamma-delta T cell proliferation relationship: RO:0002213 GO:0046630 ! positively regulates gamma-delta T cell proliferation [Term] id: GO:0046649 name: lymphocyte activation namespace: biological_process def: "A change in morphology and behavior of a lymphocyte resulting from exposure to a specific antigen, mitogen, cytokine, chemokine, cellular ligand, or soluble factor." [GOC:mgi_curators, ISBN:0781735149] is_a: GO:0045321 ! leukocyte activation intersection_of: GO:0001775 ! cell activation intersection_of: RO:0004009 CL:0000542 ! has primary input lymphocyte relationship: RO:0004009 CL:0000542 ! has primary input lymphocyte [Term] id: GO:0046651 name: lymphocyte proliferation namespace: biological_process def: "The expansion of a lymphocyte population by cell division." [GOC:ai] is_a: GO:0032943 ! mononuclear cell proliferation is_a: GO:0046649 ! lymphocyte activation intersection_of: GO:0008283 ! cell population proliferation intersection_of: RO:0012003 CL:0000542 ! acts on population of lymphocyte relationship: RO:0012003 CL:0000542 ! acts on population of lymphocyte [Term] id: GO:0046660 name: female sex differentiation namespace: biological_process def: "The establishment of the sex of a female organism by physical differentiation." [GOC:bf] is_a: GO:0007548 ! sex differentiation relationship: BFO:0000050 GO:0007275 ! part of multicellular organism development property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0046661 name: male sex differentiation namespace: biological_process def: "The establishment of the sex of a male organism by physical differentiation." [GOC:bf] is_a: GO:0007548 ! sex differentiation relationship: BFO:0000050 GO:0007275 ! part of multicellular organism development property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0046666 name: retinal cell programmed cell death namespace: biological_process def: "Programmed cell death that occurs in the developing retina." [GOC:bf] synonym: "programmed cell death, retina cells" EXACT [] synonym: "programmed cell death, retinal cells" EXACT [] synonym: "retina cell programmed cell death" EXACT [] synonym: "retina programmed cell death" EXACT [] synonym: "retinal programmed cell death" EXACT [] is_a: GO:0010623 ! programmed cell death involved in cell development relationship: BFO:0000050 GO:0048592 ! part of eye morphogenesis [Term] id: GO:0046667 name: compound eye retinal cell programmed cell death namespace: biological_process def: "Programmed cell death that occurs in the retina to remove excess cells between ommatidia, thus resulting in a hexagonal lattice, precise with respect to cell number and position surrounding each ommatidium." [PMID:12006672] is_a: GO:0046666 ! retinal cell programmed cell death intersection_of: GO:0046666 ! retinal cell programmed cell death intersection_of: RO:0002299 UBERON:0000018 ! results in maturation of compound eye relationship: BFO:0000050 GO:0001745 ! part of compound eye morphogenesis relationship: RO:0002299 UBERON:0000018 ! results in maturation of compound eye [Term] id: GO:0046668 name: regulation of retinal cell programmed cell death namespace: biological_process def: "Any process that modulates the frequency, rate or extent of programmed cell death that occurs in the retina." [GOC:ai, GOC:tb] synonym: "regulation of retinal programmed cell death" EXACT [GOC:tb] is_a: GO:0043067 ! regulation of programmed cell death is_a: GO:0050793 ! regulation of developmental process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0046666 ! regulates retinal cell programmed cell death relationship: RO:0002211 GO:0046666 ! regulates retinal cell programmed cell death [Term] id: GO:0046669 name: regulation of compound eye retinal cell programmed cell death namespace: biological_process def: "Any process that modulates the frequency, rate or extent of programmed cell death that occurs in the compound eye retina." [GOC:ai] synonym: "regulation of retinal cell programmed cell death" BROAD [] is_a: GO:0046668 ! regulation of retinal cell programmed cell death intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0046667 ! regulates compound eye retinal cell programmed cell death relationship: RO:0002211 GO:0046667 ! regulates compound eye retinal cell programmed cell death [Term] id: GO:0046670 name: positive regulation of retinal cell programmed cell death namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of programmed cell death that occurs in the retina." [GOC:ai, GOC:tb] synonym: "activation of retinal programmed cell death" NARROW [] synonym: "positive regulation of retinal programmed cell death" EXACT [GOC:tb] synonym: "stimulation of retinal programmed cell death" NARROW [] synonym: "up regulation of retinal programmed cell death" EXACT [] synonym: "up-regulation of retinal programmed cell death" EXACT [] synonym: "upregulation of retinal programmed cell death" EXACT [] is_a: GO:0043068 ! positive regulation of programmed cell death is_a: GO:0046668 ! regulation of retinal cell programmed cell death is_a: GO:0051094 ! positive regulation of developmental process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0046666 ! positively regulates retinal cell programmed cell death relationship: RO:0002213 GO:0046666 ! positively regulates retinal cell programmed cell death [Term] id: GO:0046671 name: negative regulation of retinal cell programmed cell death namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of programmed cell death that occurs in the retina." [GOC:ai, GOC:tb] synonym: "down regulation of retinal programmed cell death" EXACT [] synonym: "down-regulation of retinal programmed cell death" EXACT [] synonym: "downregulation of retinal programmed cell death" EXACT [] synonym: "inhibition of retinal programmed cell death" NARROW [] synonym: "negative regulation of retinal programmed cell death" EXACT [GOC:tb] is_a: GO:0043069 ! negative regulation of programmed cell death is_a: GO:0046668 ! regulation of retinal cell programmed cell death is_a: GO:0051093 ! negative regulation of developmental process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0046666 ! negatively regulates retinal cell programmed cell death relationship: RO:0002212 GO:0046666 ! negatively regulates retinal cell programmed cell death [Term] id: GO:0046672 name: positive regulation of compound eye retinal cell programmed cell death namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of programmed cell death that occurs in the compound eye retina." [GOC:ai] synonym: "activation of retinal cell programmed cell death" BROAD [] synonym: "positive regulation of retinal cell programmed cell death" BROAD [] synonym: "stimulation of retinal cell programmed cell death" BROAD [] synonym: "up regulation of retinal cell programmed cell death" BROAD [] synonym: "up-regulation of retinal cell programmed cell death" BROAD [] synonym: "upregulation of retinal cell programmed cell death" BROAD [] is_a: GO:0046669 ! regulation of compound eye retinal cell programmed cell death is_a: GO:0046670 ! positive regulation of retinal cell programmed cell death intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0046667 ! positively regulates compound eye retinal cell programmed cell death relationship: RO:0002213 GO:0046667 ! positively regulates compound eye retinal cell programmed cell death [Term] id: GO:0046673 name: negative regulation of compound eye retinal cell programmed cell death namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of programmed cell death that occurs in the compound eye retina." [GOC:ai] synonym: "down regulation of retinal cell programmed cell death" BROAD [] synonym: "down-regulation of retinal cell programmed cell death" BROAD [] synonym: "downregulation of retinal cell programmed cell death" BROAD [] synonym: "inhibition of retinal cell programmed cell death" BROAD [] synonym: "negative regulation of retina cell programmed cell death" BROAD [] synonym: "negative regulation of retinal cell programmed cell death" BROAD [] is_a: GO:0046669 ! regulation of compound eye retinal cell programmed cell death is_a: GO:0046671 ! negative regulation of retinal cell programmed cell death intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0046667 ! negatively regulates compound eye retinal cell programmed cell death relationship: RO:0002212 GO:0046667 ! negatively regulates compound eye retinal cell programmed cell death [Term] id: GO:0046676 name: negative regulation of insulin secretion namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of insulin." [GOC:ai] synonym: "down regulation of insulin secretion" EXACT [] synonym: "down-regulation of insulin secretion" EXACT [] synonym: "downregulation of insulin secretion" EXACT [] synonym: "inhibition of insulin secretion" NARROW [] xref: Reactome:R-HSA-400042 "Adrenaline,noradrenaline inhibits insulin secretion" is_a: GO:0050709 ! negative regulation of protein secretion is_a: GO:0050796 ! regulation of insulin secretion is_a: GO:0090278 ! negative regulation of peptide hormone secretion intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0030073 ! negatively regulates insulin secretion relationship: RO:0002212 GO:0030073 ! negatively regulates insulin secretion [Term] id: GO:0046683 name: response to organophosphorus namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organophosphorus stimulus. Organophosphorus is a compound containing phosphorus bound to an organic molecule; several organophosphorus compounds are used as insecticides, and they are highly toxic cholinesterase inhibitors." [ISBN:0721662544] synonym: "organophosphorus resistance" RELATED [] synonym: "organophosphorus susceptibility/resistance" RELATED [] is_a: GO:0042221 ! response to chemical intersection_of: GO:0050896 ! response to stimulus intersection_of: RO:0004009 CHEBI:25710 ! has primary input relationship: RO:0004009 CHEBI:25710 ! has primary input [Term] id: GO:0046697 name: decidualization namespace: biological_process def: "The cellular and vascular changes occurring in the endometrium of the pregnant uterus just after the onset of blastocyst implantation. This process involves the proliferation and differentiation of the fibroblast-like endometrial stromal cells into large, polyploid decidual cells that eventually form the maternal component of the placenta." [ISBN:0721662544, PMID:11133685] synonym: "decidual cell reaction" EXACT [] xref: Wikipedia:Decidualization is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0009888 ! tissue development relationship: BFO:0000050 GO:0001893 ! part of maternal placenta development [Term] id: GO:0046716 name: muscle cell cellular homeostasis namespace: biological_process def: "The cellular homeostatic process that preserves a muscle cell in a stable functional or structural state." [GOC:mah, PMID:3091429, PMID:7781901] synonym: "muscle fiber maintenance" NARROW [GOC:dph, GOC:tb] synonym: "muscle homeostasis" RELATED [GOC:dph] is_a: GO:0019725 ! cellular homeostasis intersection_of: GO:0019725 ! cellular homeostasis intersection_of: BFO:0000066 CL:0000187 ! occurs in muscle cell relationship: BFO:0000066 CL:0000187 ! occurs in muscle cell property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/24218" xsd:anyURI property_value: RO:0002161 NCBITaxon:4751 [Term] id: GO:0046717 name: acid secretion namespace: biological_process def: "The controlled release of acid by a cell or a tissue." [GOC:ai] is_a: GO:0046903 ! secretion [Term] id: GO:0046785 name: microtubule polymerization namespace: biological_process def: "The addition of tubulin heterodimers to one or both ends of a microtubule." [GOC:ai, GOC:go_curators] synonym: "microtubule assembly" EXACT [] synonym: "microtubule formation" RELATED [] is_a: GO:0031109 ! microtubule polymerization or depolymerization is_a: GO:0051258 ! protein polymerization is_a: GO:0097435 ! supramolecular fiber organization intersection_of: GO:0022607 ! cellular component assembly intersection_of: RO:0002588 GO:0005874 ! results in assembly of microtubule relationship: RO:0002224 GO:0007020 ! starts with microtubule nucleation relationship: RO:0002588 GO:0005874 ! results in assembly of microtubule [Term] id: GO:0046822 name: regulation of nucleocytoplasmic transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the directed movement of substances between the nucleus and the cytoplasm." [GOC:bf] is_a: GO:0032386 ! regulation of intracellular transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0006913 ! regulates nucleocytoplasmic transport relationship: RO:0002211 GO:0006913 ! regulates nucleocytoplasmic transport [Term] id: GO:0046823 name: negative regulation of nucleocytoplasmic transport namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of substances between the cytoplasm and the nucleus." [GOC:bf] synonym: "down regulation of nucleocytoplasmic transport" EXACT [] synonym: "down-regulation of nucleocytoplasmic transport" EXACT [] synonym: "downregulation of nucleocytoplasmic transport" EXACT [] synonym: "inhibition of nucleocytoplasmic transport" NARROW [] is_a: GO:0032387 ! negative regulation of intracellular transport is_a: GO:0046822 ! regulation of nucleocytoplasmic transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0006913 ! negatively regulates nucleocytoplasmic transport relationship: RO:0002212 GO:0006913 ! negatively regulates nucleocytoplasmic transport [Term] id: GO:0046824 name: positive regulation of nucleocytoplasmic transport namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the directed movement of substances between the nucleus and the cytoplasm." [GOC:bf] synonym: "activation of nucleocytoplasmic transport" NARROW [] synonym: "stimulation of nucleocytoplasmic transport" NARROW [] synonym: "up regulation of nucleocytoplasmic transport" EXACT [] synonym: "up-regulation of nucleocytoplasmic transport" EXACT [] synonym: "upregulation of nucleocytoplasmic transport" EXACT [] is_a: GO:0032388 ! positive regulation of intracellular transport is_a: GO:0046822 ! regulation of nucleocytoplasmic transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0006913 ! positively regulates nucleocytoplasmic transport relationship: RO:0002213 GO:0006913 ! positively regulates nucleocytoplasmic transport [Term] id: GO:0046825 name: regulation of protein export from nucleus namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the directed movement of proteins from the nucleus to the cytoplasm." [GOC:bf] synonym: "regulation of protein export from cell nucleus" EXACT [] synonym: "regulation of protein export out of nucleus" EXACT [] synonym: "regulation of protein transport from nucleus to cytoplasm" EXACT [] synonym: "regulation of protein-nucleus export" EXACT [] is_a: GO:0033157 ! regulation of intracellular protein transport is_a: GO:0046822 ! regulation of nucleocytoplasmic transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0006611 ! regulates protein export from nucleus relationship: RO:0002211 GO:0006611 ! regulates protein export from nucleus [Term] id: GO:0046826 name: negative regulation of protein export from nucleus namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of proteins from the nucleus into the cytoplasm." [GOC:bf] synonym: "down regulation of protein export from nucleus" EXACT [] synonym: "down-regulation of protein export from nucleus" EXACT [] synonym: "downregulation of protein export from nucleus" EXACT [] synonym: "inhibition of protein export from nucleus" NARROW [] synonym: "negative regulation of protein export from cell nucleus" EXACT [] synonym: "negative regulation of protein export out of nucleus" EXACT [] synonym: "negative regulation of protein transport from nucleus to cytoplasm" EXACT [] synonym: "negative regulation of protein-nucleus export" EXACT [] is_a: GO:0046823 ! negative regulation of nucleocytoplasmic transport is_a: GO:0046825 ! regulation of protein export from nucleus is_a: GO:0051457 ! maintenance of protein location in nucleus is_a: GO:0090317 ! negative regulation of intracellular protein transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0006611 ! negatively regulates protein export from nucleus relationship: RO:0002212 GO:0006611 ! negatively regulates protein export from nucleus [Term] id: GO:0046827 name: positive regulation of protein export from nucleus namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of directed movement of proteins from the nucleus into the cytoplasm." [GOC:bf] synonym: "activation of protein export from nucleus" NARROW [] synonym: "positive regulation of protein export from cell nucleus" EXACT [] synonym: "positive regulation of protein export out of nucleus" EXACT [] synonym: "positive regulation of protein transport from nucleus to cytoplasm" EXACT [] synonym: "positive regulation of protein-nucleus export" EXACT [] synonym: "stimulation of protein export from nucleus" NARROW [] synonym: "up regulation of protein export from nucleus" EXACT [] synonym: "up-regulation of protein export from nucleus" EXACT [] synonym: "upregulation of protein export from nucleus" EXACT [] is_a: GO:0046824 ! positive regulation of nucleocytoplasmic transport is_a: GO:0046825 ! regulation of protein export from nucleus is_a: GO:0090316 ! positive regulation of intracellular protein transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0006611 ! positively regulates protein export from nucleus relationship: RO:0002213 GO:0006611 ! positively regulates protein export from nucleus [Term] id: GO:0046828 name: regulation of RNA import into nucleus namespace: biological_process def: "Any process that modulates the frequency, rate or extent of movement of RNA from the cytoplasm to the nucleus." [GOC:bf] synonym: "regulation of RNA import into cell nucleus" EXACT [] synonym: "regulation of RNA transport from cytoplasm to nucleus" EXACT [] synonym: "regulation of RNA-nucleus import" EXACT [] is_a: GO:0032239 ! regulation of nucleobase-containing compound transport is_a: GO:0046822 ! regulation of nucleocytoplasmic transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0006404 ! regulates RNA import into nucleus relationship: RO:0002211 GO:0006404 ! regulates RNA import into nucleus [Term] id: GO:0046829 name: negative regulation of RNA import into nucleus namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the movement of RNA from the cytoplasm into the nucleus." [GOC:bf] synonym: "down regulation of RNA import into nucleus" EXACT [] synonym: "down-regulation of RNA import into nucleus" EXACT [] synonym: "downregulation of RNA import into nucleus" EXACT [] synonym: "inhibition of RNA import into nucleus" NARROW [] synonym: "negative regulation of RNA import into cell nucleus" EXACT [] synonym: "negative regulation of RNA transport from cytoplasm to nucleus" EXACT [] synonym: "negative regulation of RNA-nucleus import" EXACT [] is_a: GO:0032240 ! negative regulation of nucleobase-containing compound transport is_a: GO:0046823 ! negative regulation of nucleocytoplasmic transport is_a: GO:0046828 ! regulation of RNA import into nucleus intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0006404 ! negatively regulates RNA import into nucleus relationship: RO:0002212 GO:0006404 ! negatively regulates RNA import into nucleus [Term] id: GO:0046830 name: positive regulation of RNA import into nucleus namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of movement of RNA from the cytoplasm into the nucleus." [GOC:bf] synonym: "activation of RNA import into nucleus" NARROW [] synonym: "positive regulation of RNA import into cell nucleus" EXACT [] synonym: "positive regulation of RNA transport from cytoplasm to nucleus" EXACT [] synonym: "positive regulation of RNA-nucleus import" EXACT [] synonym: "stimulation of RNA import into nucleus" NARROW [] synonym: "up regulation of RNA import into nucleus" EXACT [] synonym: "up-regulation of RNA import into nucleus" EXACT [] synonym: "upregulation of RNA import into nucleus" EXACT [] is_a: GO:0032241 ! positive regulation of nucleobase-containing compound transport is_a: GO:0046824 ! positive regulation of nucleocytoplasmic transport is_a: GO:0046828 ! regulation of RNA import into nucleus intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0006404 ! positively regulates RNA import into nucleus relationship: RO:0002213 GO:0006404 ! positively regulates RNA import into nucleus [Term] id: GO:0046831 name: regulation of RNA export from nucleus namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the directed movement of RNA from the nucleus to the cytoplasm." [GOC:bf] synonym: "regulation of RNA export from cell nucleus" EXACT [] synonym: "regulation of RNA export out of nucleus" EXACT [] synonym: "regulation of RNA transport from nucleus to cytoplasm" EXACT [] synonym: "regulation of RNA-nucleus export" EXACT [] is_a: GO:0032239 ! regulation of nucleobase-containing compound transport is_a: GO:0046822 ! regulation of nucleocytoplasmic transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0006405 ! regulates RNA export from nucleus relationship: RO:0002211 GO:0006405 ! regulates RNA export from nucleus [Term] id: GO:0046832 name: negative regulation of RNA export from nucleus namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of RNA from the nucleus into the cytoplasm." [GOC:bf] synonym: "down regulation of RNA export from nucleus" EXACT [] synonym: "down-regulation of RNA export from nucleus" EXACT [] synonym: "downregulation of RNA export from nucleus" EXACT [] synonym: "inhibition of RNA export from nucleus" NARROW [] synonym: "negative regulation of RNA export from cell nucleus" EXACT [] synonym: "negative regulation of RNA export out of nucleus" EXACT [] synonym: "negative regulation of RNA transport from nucleus to cytoplasm" EXACT [] synonym: "negative regulation of RNA-nucleus export" EXACT [] is_a: GO:0032240 ! negative regulation of nucleobase-containing compound transport is_a: GO:0046823 ! negative regulation of nucleocytoplasmic transport is_a: GO:0046831 ! regulation of RNA export from nucleus intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0006405 ! negatively regulates RNA export from nucleus relationship: RO:0002212 GO:0006405 ! negatively regulates RNA export from nucleus [Term] id: GO:0046833 name: positive regulation of RNA export from nucleus namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of directed movement of RNA from the nucleus into the cytoplasm." [GOC:bf] synonym: "activation of RNA export from nucleus" NARROW [] synonym: "positive regulation of RNA export from cell nucleus" EXACT [] synonym: "positive regulation of RNA export out of nucleus" EXACT [] synonym: "positive regulation of RNA transport from nucleus to cytoplasm" EXACT [] synonym: "positive regulation of RNA-nucleus export" EXACT [] synonym: "stimulation of RNA export from nucleus" NARROW [] synonym: "up regulation of RNA export from nucleus" EXACT [] synonym: "up-regulation of RNA export from nucleus" EXACT [] synonym: "upregulation of RNA export from nucleus" EXACT [] is_a: GO:0032241 ! positive regulation of nucleobase-containing compound transport is_a: GO:0046824 ! positive regulation of nucleocytoplasmic transport is_a: GO:0046831 ! regulation of RNA export from nucleus intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0006405 ! positively regulates RNA export from nucleus relationship: RO:0002213 GO:0006405 ! positively regulates RNA export from nucleus [Term] id: GO:0046836 name: glycolipid transport namespace: biological_process def: "The directed movement of glycolipids, compounds containing (usually) 1-4 linked monosaccharide residues joined by a glycosyl linkage to a lipid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] is_a: GO:0006869 ! lipid transport is_a: GO:1901264 ! carbohydrate derivative transport intersection_of: GO:0006810 ! transport intersection_of: RO:0004009 CHEBI:33563 ! has primary input relationship: RO:0004009 CHEBI:33563 ! has primary input [Term] id: GO:0046848 name: hydroxyapatite binding namespace: molecular_function def: "Binding to hydroxyapatite, the calcium phosphate mineral of formula Ca10(PO4)6(OH)2 found both in rocks of nonorganic origin and as a component of bone and dentin." [PMID:2438276] synonym: "hydroxylapatite binding" EXACT [GOC:vk] is_a: BFO:0000003 is_a: GO:0036094 ! small molecule binding intersection_of: GO:0005488 ! binding intersection_of: RO:0004009 CHEBI:52255 ! has primary input relationship: RO:0004009 CHEBI:52255 ! has primary input property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/21211" xsd:anyURI [Term] id: GO:0046849 name: bone remodeling namespace: biological_process def: "The continuous turnover of bone matrix and mineral that involves first, an increase in resorption (osteoclastic activity) and later, reactive bone formation (osteoblastic activity). The process of bone remodeling takes place in the adult skeleton at discrete foci. The process ensures the mechanical integrity of the skeleton throughout life and plays an important role in calcium homeostasis. An imbalance in the regulation of bone resorption and bone formation results in many of the metabolic bone diseases, such as osteoporosis." [GOC:curators] synonym: "bone remodelling" EXACT [] xref: Wikipedia:Bone_remodeling is_a: GO:0048771 ! tissue remodeling property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0046850 name: regulation of bone remodeling namespace: biological_process def: "Any process that modulates the frequency, rate or extent of bone remodeling, the processes of bone formation and resorption that combine to maintain skeletal integrity." [GOC:ai] synonym: "regulation of bone remodelling" EXACT [] is_a: GO:0034103 ! regulation of tissue remodeling intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0046849 ! regulates bone remodeling relationship: RO:0002162 NCBITaxon:7742 ! in taxon Vertebrata relationship: RO:0002211 GO:0046849 ! regulates bone remodeling [Term] id: GO:0046851 name: negative regulation of bone remodeling namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of bone remodeling." [GOC:ai] synonym: "down regulation of bone remodeling" EXACT [] synonym: "down-regulation of bone remodeling" EXACT [] synonym: "downregulation of bone remodeling" EXACT [] synonym: "inhibition of bone remodeling" NARROW [] synonym: "negative regulation of bone remodelling" EXACT [] is_a: GO:0034104 ! negative regulation of tissue remodeling is_a: GO:0046850 ! regulation of bone remodeling intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0046849 ! negatively regulates bone remodeling relationship: RO:0002212 GO:0046849 ! negatively regulates bone remodeling [Term] id: GO:0046852 name: positive regulation of bone remodeling namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of bone remodeling." [GOC:ai] synonym: "activation of bone remodeling" NARROW [] synonym: "positive regulation of bone remodelling" EXACT [] synonym: "stimulation of bone remodeling" NARROW [] synonym: "up regulation of bone remodeling" EXACT [] synonym: "up-regulation of bone remodeling" EXACT [] synonym: "upregulation of bone remodeling" EXACT [] is_a: GO:0034105 ! positive regulation of tissue remodeling is_a: GO:0046850 ! regulation of bone remodeling intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0046849 ! positively regulates bone remodeling relationship: RO:0002213 GO:0046849 ! positively regulates bone remodeling [Term] id: GO:0046864 name: isoprenoid transport namespace: biological_process def: "The directed movement of isoprenoids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Isoprenoids comprise a group of compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues." [GOC:ai] subset: goslim_pir is_a: GO:0006869 ! lipid transport intersection_of: GO:0006810 ! transport intersection_of: RO:0004009 CHEBI:24913 ! has primary input relationship: RO:0004009 CHEBI:24913 ! has primary input [Term] id: GO:0046865 name: terpenoid transport namespace: biological_process def: "The directed movement of terpenoids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Terpenoids are a class of compounds characterized by an isoprenoid chemical structure and include derivatives with various functional groups." [GOC:ai] is_a: GO:0046864 ! isoprenoid transport intersection_of: GO:0006810 ! transport intersection_of: RO:0004009 CHEBI:26873 ! has primary input relationship: RO:0004009 CHEBI:26873 ! has primary input [Term] id: GO:0046866 name: tetraterpenoid transport namespace: biological_process def: "The directed movement of tetraterpenoids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Tetraterpenoids are terpenoids with eight isoprene units." [GOC:ai] is_a: GO:0046865 ! terpenoid transport intersection_of: GO:0006810 ! transport intersection_of: RO:0004009 CHEBI:26935 ! has primary input relationship: RO:0004009 CHEBI:26935 ! has primary input [Term] id: GO:0046867 name: carotenoid transport namespace: biological_process def: "The directed movement of carotenoids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Carotenoids are tetraterpenoid compounds in which two units of 4 isoprenoid residues joined head-to-tail are themselves joined tail-to-tail." [GOC:ai] is_a: GO:0046866 ! tetraterpenoid transport intersection_of: GO:0006810 ! transport intersection_of: RO:0004009 CHEBI:23044 ! has primary input relationship: RO:0004009 CHEBI:23044 ! has primary input [Term] id: GO:0046872 name: metal ion binding namespace: molecular_function def: "Binding to a metal ion." [GOC:ai] subset: goslim_agr subset: goslim_drosophila subset: goslim_flybase_ribbon subset: goslim_metagenomics synonym: "heavy metal binding" NARROW [] synonym: "metal binding" EXACT [] is_a: GO:0043169 ! cation binding intersection_of: GO:0005488 ! binding intersection_of: RO:0004009 CHEBI:25213 ! has primary input relationship: RO:0004009 CHEBI:25213 ! has primary input [Term] id: GO:0046873 name: metal ion transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of metal ions from one side of a membrane to the other." [GOC:ai] synonym: "heavy metal ion porter activity" NARROW [] synonym: "heavy metal ion transporter activity" NARROW [] synonym: "heavy metal ion:hydrogen symporter activity" NARROW [] synonym: "heavy metal-exporting ATPase activity" NARROW [] synonym: "high affinity metal ion uptake transporter activity" NARROW [] synonym: "low affinity metal ion uptake transporter activity" NARROW [] is_a: GO:0008324 ! monoatomic cation transmembrane transporter activity intersection_of: GO:0022857 ! transmembrane transporter activity intersection_of: RO:0004009 CHEBI:25213 ! has primary input relationship: BFO:0000050 GO:0030001 ! part of metal ion transport relationship: RO:0004009 CHEBI:25213 ! has primary input [Term] id: GO:0046877 name: regulation of saliva secretion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the regulated release of saliva from a cell or a tissue." [GOC:ai] is_a: GO:0044058 ! regulation of digestive system process is_a: GO:0050878 ! regulation of body fluid levels is_a: GO:0051046 ! regulation of secretion intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0046541 ! regulates saliva secretion relationship: RO:0002211 GO:0046541 ! regulates saliva secretion property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0046878 name: positive regulation of saliva secretion namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the regulated release of saliva." [GOC:ai] synonym: "activation of saliva secretion" NARROW [] synonym: "stimulation of saliva secretion" NARROW [] synonym: "up regulation of saliva secretion" EXACT [] synonym: "up-regulation of saliva secretion" EXACT [] synonym: "upregulation of saliva secretion" EXACT [] is_a: GO:0046877 ! regulation of saliva secretion is_a: GO:0051047 ! positive regulation of secretion is_a: GO:0060456 ! positive regulation of digestive system process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0046541 ! positively regulates saliva secretion relationship: RO:0002213 GO:0046541 ! positively regulates saliva secretion property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0046879 name: hormone secretion namespace: biological_process def: "The regulated release of hormones, substances with a specific regulatory effect on a particular organ or group of cells." [ISBN:0198506732] is_a: GO:0009914 ! hormone transport is_a: GO:0023061 ! signal release [Term] id: GO:0046883 name: regulation of hormone secretion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the regulated release of a hormone from a cell." [GOC:ai] is_a: GO:0010646 ! regulation of cell communication is_a: GO:0010817 ! regulation of hormone levels is_a: GO:0023051 ! regulation of signaling is_a: GO:1903530 ! regulation of secretion by cell intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0046879 ! regulates hormone secretion relationship: RO:0002211 GO:0046879 ! regulates hormone secretion [Term] id: GO:0046885 name: regulation of hormone biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of hormones." [GOC:ai] synonym: "regulation of hormone anabolism" EXACT [] synonym: "regulation of hormone biosynthesis" EXACT [] synonym: "regulation of hormone formation" EXACT [] synonym: "regulation of hormone synthesis" EXACT [] is_a: GO:0009889 ! regulation of biosynthetic process is_a: GO:0032350 ! regulation of hormone metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0042446 ! regulates hormone biosynthetic process relationship: RO:0002211 GO:0042446 ! regulates hormone biosynthetic process property_value: RO:0002161 NCBITaxon:4895 [Term] id: GO:0046886 name: positive regulation of hormone biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of hormones." [GOC:ai] synonym: "activation of hormone biosynthetic process" NARROW [] synonym: "positive regulation of hormone anabolism" EXACT [] synonym: "positive regulation of hormone biosynthesis" EXACT [] synonym: "positive regulation of hormone formation" EXACT [] synonym: "positive regulation of hormone synthesis" EXACT [] synonym: "stimulation of hormone biosynthetic process" NARROW [] synonym: "up regulation of hormone biosynthetic process" EXACT [] synonym: "up-regulation of hormone biosynthetic process" EXACT [] synonym: "upregulation of hormone biosynthetic process" EXACT [] is_a: GO:0009891 ! positive regulation of biosynthetic process is_a: GO:0032352 ! positive regulation of hormone metabolic process is_a: GO:0046885 ! regulation of hormone biosynthetic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0042446 ! positively regulates hormone biosynthetic process relationship: RO:0002213 GO:0042446 ! positively regulates hormone biosynthetic process property_value: RO:0002161 NCBITaxon:4895 [Term] id: GO:0046887 name: positive regulation of hormone secretion namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the regulated release of a hormone from a cell." [GOC:ai] synonym: "activation of hormone secretion" NARROW [] synonym: "stimulation of hormone secretion" NARROW [] synonym: "up regulation of hormone secretion" EXACT [] synonym: "up-regulation of hormone secretion" EXACT [] synonym: "upregulation of hormone secretion" EXACT [] is_a: GO:0010647 ! positive regulation of cell communication is_a: GO:0023056 ! positive regulation of signaling is_a: GO:0046883 ! regulation of hormone secretion is_a: GO:1903532 ! positive regulation of secretion by cell intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0046879 ! positively regulates hormone secretion relationship: RO:0002213 GO:0046879 ! positively regulates hormone secretion [Term] id: GO:0046888 name: negative regulation of hormone secretion namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of a hormone from a cell." [GOC:ai] synonym: "down regulation of hormone secretion" EXACT [] synonym: "down-regulation of hormone secretion" EXACT [] synonym: "downregulation of hormone secretion" EXACT [] synonym: "inhibition of hormone secretion" NARROW [] is_a: GO:0010648 ! negative regulation of cell communication is_a: GO:0023057 ! negative regulation of signaling is_a: GO:0046883 ! regulation of hormone secretion is_a: GO:1903531 ! negative regulation of secretion by cell intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0046879 ! negatively regulates hormone secretion relationship: RO:0002212 GO:0046879 ! negatively regulates hormone secretion [Term] id: GO:0046889 name: positive regulation of lipid biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of lipids." [GOC:ai] synonym: "activation of lipid biosynthetic process" NARROW [] synonym: "positive regulation of lipid anabolism" EXACT [] synonym: "positive regulation of lipid biosynthesis" EXACT [] synonym: "positive regulation of lipid formation" EXACT [] synonym: "positive regulation of lipid synthesis" EXACT [] synonym: "positive regulation of lipogenesis" EXACT [GOC:sl] synonym: "stimulation of lipid biosynthetic process" NARROW [] synonym: "up regulation of lipid biosynthetic process" EXACT [] synonym: "up-regulation of lipid biosynthetic process" EXACT [] synonym: "upregulation of lipid biosynthetic process" EXACT [] is_a: GO:0009891 ! positive regulation of biosynthetic process is_a: GO:0045834 ! positive regulation of lipid metabolic process is_a: GO:0046890 ! regulation of lipid biosynthetic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0008610 ! positively regulates lipid biosynthetic process relationship: RO:0002213 GO:0008610 ! positively regulates lipid biosynthetic process [Term] id: GO:0046890 name: regulation of lipid biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of lipids." [GOC:ai] synonym: "regulation of lipid anabolism" EXACT [] synonym: "regulation of lipid biosynthesis" EXACT [] synonym: "regulation of lipid formation" EXACT [] synonym: "regulation of lipid synthesis" EXACT [] synonym: "regulation of lipogenesis" EXACT [GOC:sl] is_a: GO:0009889 ! regulation of biosynthetic process is_a: GO:0019216 ! regulation of lipid metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0008610 ! regulates lipid biosynthetic process relationship: RO:0002211 GO:0008610 ! regulates lipid biosynthetic process [Term] id: GO:0046903 name: secretion namespace: biological_process def: "The controlled release of a substance by a cell or a tissue." [GOC:ai] subset: goslim_pir is_a: GO:0006810 ! transport [Term] id: GO:0046907 name: intracellular transport namespace: biological_process def: "The directed movement of substances within a cell." [GOC:ai] subset: gocheck_do_not_annotate synonym: "single organism intracellular transport" RELATED [GOC:TermGenie] synonym: "single-organism intracellular transport" RELATED [] is_a: GO:0006810 ! transport is_a: GO:0051641 ! cellular localization is_a: GO:0051649 ! establishment of localization in cell intersection_of: GO:0006810 ! transport intersection_of: BFO:0000066 GO:0005622 ! occurs in intracellular anatomical structure relationship: BFO:0000066 GO:0005622 ! occurs in intracellular anatomical structure creation_date: 2013-12-18T14:04:50Z [Term] id: GO:0046914 name: transition metal ion binding namespace: molecular_function def: "Binding to a transition metal ions; a transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver." [ISBN:0198506732] is_a: GO:0046872 ! metal ion binding intersection_of: GO:0005488 ! binding intersection_of: RO:0004009 CHEBI:33515 ! has primary input relationship: RO:0004009 CHEBI:33515 ! has primary input [Term] id: GO:0046915 name: transition metal ion transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of transition metal ions from one side of a membrane to the other. A transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver." [ISBN:0198506732] is_a: GO:0046873 ! metal ion transmembrane transporter activity intersection_of: GO:0022857 ! transmembrane transporter activity intersection_of: RO:0004009 CHEBI:33515 ! has primary input relationship: BFO:0000050 GO:0000041 ! part of transition metal ion transport relationship: RO:0004009 CHEBI:33515 ! has primary input [Term] id: GO:0046928 name: regulation of neurotransmitter secretion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the regulated release of a neurotransmitter from a cell." [GOC:ai] is_a: GO:0050804 ! modulation of chemical synaptic transmission is_a: GO:0051588 ! regulation of neurotransmitter transport is_a: GO:1903530 ! regulation of secretion by cell intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0007269 ! regulates neurotransmitter secretion relationship: RO:0002211 GO:0007269 ! regulates neurotransmitter secretion [Term] id: GO:0046929 name: negative regulation of neurotransmitter secretion namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of a neurotransmitter." [GOC:ai] synonym: "conotoxin activity" NARROW [] synonym: "down regulation of neurotransmitter secretion" EXACT [] synonym: "down-regulation of neurotransmitter secretion" EXACT [] synonym: "downregulation of neurotransmitter secretion" EXACT [] synonym: "inhibition of neurotransmitter secretion" NARROW [] is_a: GO:0046928 ! regulation of neurotransmitter secretion is_a: GO:0051589 ! negative regulation of neurotransmitter transport is_a: GO:1903531 ! negative regulation of secretion by cell intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0007269 ! negatively regulates neurotransmitter secretion relationship: RO:0002212 GO:0007269 ! negatively regulates neurotransmitter secretion [Term] id: GO:0046930 name: pore complex namespace: cellular_component def: "A protein complex providing a discrete opening in a membrane that allows the passage of gases and/or liquids." [ISBN:0198506732] synonym: "channel-forming toxin activity" RELATED [] synonym: "pore" EXACT [] synonym: "pore-forming toxin activity" RELATED [] is_a: GO:0098796 ! membrane protein complex property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/20452" xsd:anyURI [Term] id: GO:0046931 name: pore complex assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form a pore complex. A pore complex is a small opening in a membrane that allows the passage of liquids and/or gases." [GOC:jl, GOC:mah] comment: See also the cellular component term 'pore complex ; GO:0046930'. synonym: "pore biosynthesis" EXACT [] synonym: "pore complex biogenesis" RELATED [GOC:mah] synonym: "pore formation" EXACT [] synonym: "pore-forming toxin activity" RELATED [] is_a: GO:0065003 ! protein-containing complex assembly intersection_of: GO:0022607 ! cellular component assembly intersection_of: RO:0002588 GO:0046930 ! results in assembly of pore complex relationship: RO:0002588 GO:0046930 ! results in assembly of pore complex [Term] id: GO:0046942 name: carboxylic acid transport namespace: biological_process def: "The directed movement of carboxylic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Carboxylic acids are organic acids containing one or more carboxyl (COOH) groups or anions (COO-)." [GOC:ai] is_a: GO:0015711 ! organic anion transport is_a: GO:0015849 ! organic acid transport intersection_of: GO:0006810 ! transport intersection_of: RO:0004009 CHEBI:29067 ! has primary input relationship: RO:0004009 CHEBI:29067 ! has primary input [Term] id: GO:0046943 name: carboxylic acid transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of carboxylic acids from one side of a membrane to the other. Carboxylic acids are organic acids containing one or more carboxyl (COOH) groups or anions (COO-)." [GOC:ai] xref: Reactome:R-HSA-390347 "Exchange of isocitrate and 2-oxoglutarate across the peroxisomal membrane" is_a: GO:0022857 ! transmembrane transporter activity intersection_of: GO:0022857 ! transmembrane transporter activity intersection_of: RO:0004009 CHEBI:29067 ! has primary input relationship: BFO:0000050 GO:1905039 ! part of carboxylic acid transmembrane transport relationship: RO:0004009 CHEBI:29067 ! has primary input [Term] id: GO:0047496 name: vesicle transport along microtubule namespace: biological_process def: "The directed movement of a vesicle along a microtubule, mediated by motor proteins. This process begins with the attachment of a vesicle to a microtubule, and ends when the vesicle reaches its final destination." [GOC:ecd, GOC:rl] synonym: "microtubule-based vesicle localization" EXACT [GOC:rl] is_a: GO:0072384 ! organelle transport along microtubule is_a: GO:0099518 ! vesicle cytoskeletal trafficking intersection_of: GO:0006810 ! transport intersection_of: RO:0002341 GO:0005874 ! results in transport along microtubule intersection_of: RO:0004009 GO:0031982 ! has primary input vesicle [Term] id: GO:0047497 name: mitochondrion transport along microtubule namespace: biological_process def: "The directed movement of a mitochondrion along a microtubule, mediated by motor proteins." [GOC:ecd] synonym: "mitochondrial migration along microtubule" EXACT [] synonym: "mitochondrial transport along microtubule" EXACT [] is_a: GO:0034643 ! establishment of mitochondrion localization, microtubule-mediated is_a: GO:0072384 ! organelle transport along microtubule intersection_of: GO:0006810 ! transport intersection_of: RO:0002341 GO:0005874 ! results in transport along microtubule intersection_of: RO:0004009 GO:0005739 ! has primary input mitochondrion [Term] id: GO:0048002 name: antigen processing and presentation of peptide antigen namespace: biological_process def: "The process in which an antigen-presenting cell expresses peptide antigen in association with an MHC protein complex on its cell surface, including proteolysis and transport steps for the peptide antigen both prior to and following assembly with the MHC protein complex. The peptide antigen is typically, but not always, processed from an endogenous or exogenous protein." [GOC:add, ISBN:0781735149, PMID:15771591] synonym: "antigen presentation, peptide antigen" EXACT [] synonym: "peptide antigen processing and presentation" EXACT [] is_a: GO:0019882 ! antigen processing and presentation property_value: RO:0002161 NCBITaxon:4895 [Term] id: GO:0048020 name: CCR chemokine receptor binding namespace: molecular_function def: "Binding to a CCR chemokine receptor." [GOC:ai] synonym: "beta chemokine receptor binding" EXACT [] synonym: "beta chemokine receptor ligand" NARROW [] synonym: "CCR chemokine receptor ligand" NARROW [] is_a: GO:0042379 ! chemokine receptor binding [Term] id: GO:0048029 name: monosaccharide binding namespace: molecular_function def: "Binding to a monosaccharide. Monosaccharides are the simplest carbohydrates; they are polyhydroxy aldehydes H[CH(OH)]nC(=O)H or polyhydroxy ketones H[CHOH]nC(=O)[CHOH]mH with three or more carbon atoms. They form the constitutional repeating units of oligo- and polysaccharides." [GOC:jid] is_a: GO:0030246 ! carbohydrate binding is_a: GO:0036094 ! small molecule binding intersection_of: GO:0005488 ! binding intersection_of: RO:0004009 CHEBI:35381 ! has primary input relationship: RO:0004009 CHEBI:35381 ! has primary input [Term] id: GO:0048048 name: embryonic eye morphogenesis namespace: biological_process def: "The process occurring in the embryo by which the anatomical structures of the post-embryonic eye are generated and organized." [GOC:jid] is_a: GO:0048562 ! embryonic organ morphogenesis is_a: GO:0048592 ! eye morphogenesis [Term] id: GO:0048066 name: developmental pigmentation namespace: biological_process def: "The developmental process that results in the deposition of coloring matter in an organism, tissue or cell." [ISBN:0582227089] synonym: "pigmentation during development" RELATED [] is_a: GO:0043473 ! pigmentation [Term] id: GO:0048070 name: regulation of developmental pigmentation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the developmental process that results in the deposition of coloring matter in an organism." [GOC:dph, GOC:jid, GOC:tb] synonym: "regulation of pigmentation during development" EXACT [GOC:dph, GOC:tb] is_a: GO:0120305 ! regulation of pigmentation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0048066 ! regulates developmental pigmentation relationship: RO:0002211 GO:0048066 ! regulates developmental pigmentation [Term] id: GO:0048086 name: negative regulation of developmental pigmentation namespace: biological_process def: "Any process that decreases the frequency, rate or extent of the developmental process that results in the deposition of coloring matter in an organism." [GOC:dph, GOC:jid, GOC:tb] synonym: "down regulation of developmental pigmentation" EXACT [GOC:dph, GOC:tb] synonym: "down-regulation of developmental pigmentation" EXACT [GOC:dph, GOC:tb] synonym: "downregulation of developmental pigmentation" EXACT [GOC:dph, GOC:tb] synonym: "inhibition of pigmentation" NARROW [] is_a: GO:0048070 ! regulation of developmental pigmentation is_a: GO:0048519 ! negative regulation of biological process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0048066 ! negatively regulates developmental pigmentation relationship: RO:0002212 GO:0048066 ! negatively regulates developmental pigmentation [Term] id: GO:0048087 name: positive regulation of developmental pigmentation namespace: biological_process def: "Any process that increases the frequency, rate or extent of the developmental process that results in the deposition of coloring matter in an organism." [GOC:dph, GOC:jid, GOC:tb] synonym: "activation of developmental pigmentation" NARROW [GOC:dph, GOC:tb] synonym: "stimulation of developmental pigmentation" NARROW [GOC:dph, GOC:tb] synonym: "up regulation of developmental pigmentation" EXACT [GOC:dph] synonym: "up-regulation of developmental pigmentation" EXACT [GOC:dph, GOC:tb] synonym: "upregulation of developmental pigmentation" EXACT [GOC:dph, GOC:tb] is_a: GO:0048070 ! regulation of developmental pigmentation is_a: GO:0048518 ! positive regulation of biological process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0048066 ! positively regulates developmental pigmentation relationship: RO:0002213 GO:0048066 ! positively regulates developmental pigmentation [Term] id: GO:0048103 name: somatic stem cell division namespace: biological_process def: "The self-renewing division of a somatic stem cell, a stem cell that can give rise to cell types of the body other than those of the germ-line." [GOC:jid, ISBN:0582227089] synonym: "somatic stem cell renewal" EXACT [] is_a: GO:0017145 ! stem cell division intersection_of: GO:0051301 ! cell division intersection_of: RO:0004009 CL:0000723 ! has primary input somatic stem cell relationship: RO:0004009 CL:0000723 ! has primary input somatic stem cell property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4751 [Term] id: GO:0048132 name: female germ-line stem cell asymmetric division namespace: biological_process def: "The self-renewing division of a germline stem cell in the female gonad, to produce a daughter stem cell and a daughter germ cell, which will divide to form the female gametes." [GOC:jid, GOC:mtg_sensu] synonym: "female germ-line stem cell renewal" EXACT [] is_a: GO:0098728 ! germline stem cell asymmetric division intersection_of: GO:0008356 ! asymmetric cell division intersection_of: RO:0004009 CL:0000022 ! has primary input female germ line stem cell relationship: BFO:0000050 GO:0048477 ! part of oogenesis relationship: RO:0002162 NCBITaxon:6656 ! in taxon Arthropoda relationship: RO:0004009 CL:0000022 ! has primary input female germ line stem cell [Term] id: GO:0048133 name: male germ-line stem cell asymmetric division namespace: biological_process def: "The self-renewing division of a germline stem cell in the male gonad, to produce a daughter stem cell and a daughter germ cell, which will divide to form the male gametes." [GOC:jid] synonym: "male germ-line stem cell renewal" EXACT [] is_a: GO:0098728 ! germline stem cell asymmetric division intersection_of: GO:0008356 ! asymmetric cell division intersection_of: RO:0004009 CL:0000016 ! has primary input male germ line stem cell relationship: BFO:0000050 GO:0007283 ! part of spermatogenesis relationship: RO:0004009 CL:0000016 ! has primary input male germ line stem cell property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4751 [Term] id: GO:0048137 name: spermatocyte division namespace: biological_process def: "The meiotic divisions undergone by the primary and secondary spermatocytes to produce haploid spermatids." [GOC:jid, GOC:pr, ISBN:0879694238] synonym: "spermatocyte cell division" EXACT [] is_a: BFO:0000003 is_a: GO:0051301 ! cell division intersection_of: GO:0051301 ! cell division intersection_of: RO:0004009 CL:0000017 ! has primary input spermatocyte relationship: BFO:0000050 GO:0007283 ! part of spermatogenesis relationship: RO:0004009 CL:0000017 ! has primary input spermatocyte property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4751 [Term] id: GO:0048143 name: astrocyte activation namespace: biological_process def: "A change in morphology and behavior of an astrocyte resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor." [GOC:mgi_curators, PMID:10526094, PMID:10695728, PMID:12529254, PMID:12580336, PMID:9585813] is_a: GO:0061900 ! glial cell activation intersection_of: GO:0001775 ! cell activation intersection_of: RO:0004009 CL:0000127 ! has primary input astrocyte relationship: BFO:0000050 GO:0014002 ! part of astrocyte development relationship: RO:0004009 CL:0000127 ! has primary input astrocyte [Term] id: GO:0048144 name: fibroblast proliferation namespace: biological_process def: "The multiplication or reproduction of fibroblast cells, resulting in the expansion of the fibroblast population." [GOC:jid] is_a: BFO:0000003 is_a: GO:0008283 ! cell population proliferation intersection_of: GO:0008283 ! cell population proliferation intersection_of: RO:0012003 CL:0000057 ! acts on population of fibroblast relationship: RO:0012003 CL:0000057 ! acts on population of fibroblast property_value: RO:0002161 NCBITaxon:4751 [Term] id: GO:0048145 name: regulation of fibroblast proliferation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of multiplication or reproduction of fibroblast cells." [GOC:jid] is_a: GO:0042127 ! regulation of cell population proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0048144 ! regulates fibroblast proliferation relationship: RO:0002211 GO:0048144 ! regulates fibroblast proliferation property_value: RO:0002161 NCBITaxon:4751 [Term] id: GO:0048146 name: positive regulation of fibroblast proliferation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of multiplication or reproduction of fibroblast cells." [GOC:jid] synonym: "activation of fibroblast proliferation" NARROW [] synonym: "stimulation of fibroblast proliferation" NARROW [] synonym: "up regulation of fibroblast proliferation" EXACT [] synonym: "up-regulation of fibroblast proliferation" EXACT [] synonym: "upregulation of fibroblast proliferation" EXACT [] is_a: GO:0008284 ! positive regulation of cell population proliferation is_a: GO:0048145 ! regulation of fibroblast proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0048144 ! positively regulates fibroblast proliferation relationship: RO:0002213 GO:0048144 ! positively regulates fibroblast proliferation property_value: RO:0002161 NCBITaxon:4751 [Term] id: GO:0048147 name: negative regulation of fibroblast proliferation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of multiplication or reproduction of fibroblast cells." [GOC:jid] synonym: "down regulation of fibroblast proliferation" EXACT [] synonym: "down-regulation of fibroblast proliferation" EXACT [] synonym: "downregulation of fibroblast proliferation" EXACT [] synonym: "inhibition of fibroblast proliferation" NARROW [] is_a: GO:0008285 ! negative regulation of cell population proliferation is_a: GO:0048145 ! regulation of fibroblast proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0048144 ! negatively regulates fibroblast proliferation relationship: RO:0002212 GO:0048144 ! negatively regulates fibroblast proliferation property_value: RO:0002161 NCBITaxon:4751 [Term] id: GO:0048162 name: multi-layer follicle stage namespace: biological_process def: "The stage in oogenesis when many layers of follicle cells surround the oocyte. There is a yolk nucleus (Balbiani's Body) near the germinal vesicle." [GOC:jid, GOC:mtg_sensu, ISBN:0198542771] synonym: "mammalian oogenesis stage 5" EXACT [] is_a: GO:0022605 ! mammalian oogenesis stage relationship: RO:0002162 NCBITaxon:40674 ! in taxon Mammalia [Term] id: GO:0048165 name: fused antrum stage namespace: biological_process def: "The stage in oogenesis when the antral spaces fuse to form a single antral space. The oocyte is suspended in the cumulus oophorous and the first polar body in the perivitelline space." [GOC:jid, GOC:mtg_sensu, ISBN:0198542771] synonym: "mammalian oogenesis stage 8" EXACT [] is_a: GO:0022605 ! mammalian oogenesis stage relationship: RO:0002162 NCBITaxon:40674 ! in taxon Mammalia [Term] id: GO:0048193 name: Golgi vesicle transport namespace: biological_process def: "The directed movement of substances into, out of or within the Golgi apparatus, mediated by vesicles." [GOC:jid, ISBN:0716731363, PMID:10219233] subset: goslim_yeast synonym: "Golgi-derived vesicle transport" RELATED [] is_a: GO:0016192 ! vesicle-mediated transport intersection_of: GO:0016192 ! vesicle-mediated transport intersection_of: RO:0002344 GO:0005798 ! results in transport to from or in Golgi-associated vesicle relationship: RO:0002344 GO:0005798 ! results in transport to from or in Golgi-associated vesicle [Term] id: GO:0048194 name: Golgi vesicle budding namespace: biological_process def: "The evagination of the Golgi membrane, resulting in formation of a vesicle." [GOC:jid, ISBN:0716731363, PMID:10219233] synonym: "dictyosome vesicle budding" NARROW [] synonym: "Golgi-derived vesicle budding" EXACT [] is_a: GO:0006900 ! vesicle budding from membrane intersection_of: GO:0006900 ! vesicle budding from membrane intersection_of: BFO:0000066 GO:0000139 ! occurs in Golgi membrane intersection_of: RO:0004008 GO:0005798 ! has primary output Golgi-associated vesicle relationship: BFO:0000050 GO:0048193 ! part of Golgi vesicle transport relationship: BFO:0000066 GO:0000139 ! occurs in Golgi membrane relationship: RO:0004008 GO:0005798 ! has primary output Golgi-associated vesicle [Term] id: GO:0048199 name: vesicle targeting, to, from or within Golgi namespace: biological_process def: "The process in which vesicles are directed to specific destination membranes during transport to, from or within the Golgi apparatus; mediated by the addition of specific coat proteins, including COPI and COPII proteins and clathrin, to the membrane during vesicle formation." [GOC:jid, GOC:mah, ISBN:0716731363, PMID:10219233] synonym: "dictyosome vesicle targeting" NARROW [] synonym: "Golgi vesicle targeting" EXACT [] synonym: "vesicle targeting, to, from or within dictyosome" NARROW [] is_a: GO:0006903 ! vesicle targeting intersection_of: GO:0006903 ! vesicle targeting intersection_of: RO:0002344 GO:0005794 ! results in transport to from or in Golgi apparatus intersection_of: RO:0004009 GO:0005798 ! has primary input Golgi-associated vesicle relationship: BFO:0000050 GO:0048193 ! part of Golgi vesicle transport relationship: RO:0002344 GO:0005794 ! results in transport to from or in Golgi apparatus relationship: RO:0004009 GO:0005798 ! has primary input Golgi-associated vesicle [Term] id: GO:0048209 name: regulation of vesicle targeting, to, from or within Golgi namespace: biological_process def: "Any process that modulates the frequency, rate, or destination of vesicle-mediated transport to, from or within the Golgi apparatus." [GOC:jid, GOC:mah, ISBN:0716731363, PMID:10219233] synonym: "regulation of Golgi vesicle targeting" EXACT [] is_a: GO:0060341 ! regulation of cellular localization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0048199 ! regulates vesicle targeting, to, from or within Golgi relationship: RO:0002211 GO:0048199 ! regulates vesicle targeting, to, from or within Golgi [Term] id: GO:0048232 name: male gamete generation namespace: biological_process def: "Generation of the male gamete; specialised haploid cells produced by meiosis and along with a female gamete takes part in sexual reproduction." [GOC:dph, GOC:jid] is_a: GO:0007276 ! gamete generation property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4751 [Term] id: GO:0048240 name: sperm capacitation namespace: biological_process def: "A process required for sperm to reach fertilization competence. Sperm undergo an incompletely understood series of morphological and molecular maturational processes, termed capacitation, involving, among other processes, protein tyrosine phosphorylation and increased intracellular calcium." [GOC:jid, ISBN:978-3-642-58301-8, PMID:11820818] comment: Avian spermatozoa do not require a period of capacitation, since they are competent to fertilize the egg without a prolonged sojourn in the oviduct or in a capacitation medium in vitro. Therefore, sperm capacitation can only be applied to Aves to refer to gene products involved in processes that occur prior to sperm being deposited from the avian male. The term cannot apply to processes occurring in the avian female reproductive tract. synonym: "sperm activation" RELATED [PMID:23180860] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism is_a: GO:0048469 ! cell maturation relationship: BFO:0000050 GO:0007286 ! part of spermatid development property_value: RO:0002161 NCBITaxon:3176 property_value: RO:0002161 NCBITaxon:3378 property_value: RO:0002161 NCBITaxon:3398 property_value: RO:0002161 NCBITaxon:4751 property_value: RO:0002161 NCBITaxon:5782 [Term] id: GO:0048241 name: epinephrine transport namespace: biological_process def: "The directed movement of epinephrine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jid] synonym: "adrenaline transport" EXACT [] is_a: GO:0015695 ! organic cation transport is_a: GO:0051937 ! catecholamine transport intersection_of: GO:0006810 ! transport intersection_of: RO:0004009 CHEBI:71406 ! has primary input relationship: RO:0004009 CHEBI:71406 ! has primary input [Term] id: GO:0048242 name: epinephrine secretion namespace: biological_process def: "The regulated release of epinephrine by a cell. Epinephrine is a catecholamine hormone secreted by the adrenal medulla and a neurotransmitter, released by certain neurons and active in the central nervous system." [GOC:ef, GOC:jid] synonym: "adrenaline secretion" EXACT [] is_a: GO:0048241 ! epinephrine transport is_a: GO:0050432 ! catecholamine secretion intersection_of: GO:0046903 ! secretion intersection_of: RO:0004009 CHEBI:71406 ! has primary input [Term] id: GO:0048243 name: norepinephrine secretion namespace: biological_process def: "The regulated release of norepinephrine by a cell. Norepinephrine is a catecholamine and it acts as a hormone and as a neurotransmitter of most of the sympathetic nervous system." [GOC:ef, GOC:jid] synonym: "noradrenaline secretion" EXACT [] is_a: GO:0015874 ! norepinephrine transport is_a: GO:0023061 ! signal release is_a: GO:0050432 ! catecholamine secretion intersection_of: GO:0046903 ! secretion intersection_of: RO:0004009 CHEBI:72587 ! has primary input [Term] id: GO:0048245 name: eosinophil chemotaxis namespace: biological_process def: "The movement of an eosinophil in response to an external stimulus." [GOC:jid, PMID:11292027, PMID:12391252] is_a: GO:0071621 ! granulocyte chemotaxis is_a: GO:0072677 ! eosinophil migration intersection_of: GO:0006935 ! chemotaxis intersection_of: RO:0002565 CL:0000771 ! results in movement of eosinophil [Term] id: GO:0048246 name: macrophage chemotaxis namespace: biological_process def: "The movement of a macrophage in response to an external stimulus." [GOC:jid] is_a: GO:0030595 ! leukocyte chemotaxis is_a: GO:1905517 ! macrophage migration intersection_of: GO:0006935 ! chemotaxis intersection_of: RO:0002565 CL:0000235 ! results in movement of macrophage [Term] id: GO:0048247 name: lymphocyte chemotaxis namespace: biological_process def: "The directed movement of a lymphocyte in response to an external stimulus." [GOC:hjd, GOC:jid, PMID:12391252] is_a: GO:0030595 ! leukocyte chemotaxis is_a: GO:0072676 ! lymphocyte migration intersection_of: GO:0006935 ! chemotaxis intersection_of: RO:0002565 CL:0000542 ! results in movement of lymphocyte [Term] id: GO:0048250 name: iron import into the mitochondrion namespace: biological_process def: "The process in which iron is transported from the cytosol into the mitochondrial matrix." [GOC:jid, PMID:12006577] synonym: "mitochondrial iron cation transmembrane transport" EXACT [] synonym: "mitochondrial iron ion transmembrane transport" RELATED [] synonym: "mitochondrial iron ion transport" RELATED [] synonym: "mitochondrial iron transport" EXACT [] is_a: GO:0034755 ! iron ion transmembrane transport intersection_of: GO:0006810 ! transport intersection_of: RO:0002338 GO:0005829 ! has target start location cytosol intersection_of: RO:0002339 GO:0005759 ! has target end location mitochondrial matrix intersection_of: RO:0002342 GO:0031966 ! results in transport across mitochondrial membrane intersection_of: RO:0004009 CHEBI:24875 ! has primary input relationship: RO:0002338 GO:0005829 ! has target start location cytosol relationship: RO:0002339 GO:0005759 ! has target end location mitochondrial matrix relationship: RO:0002342 GO:0031966 ! results in transport across mitochondrial membrane creation_date: 2016-02-10T11:24:22Z [Term] id: GO:0048251 name: elastic fiber assembly namespace: biological_process def: "Assembly of the extracellular matrix fibers that enables the matrix to recoil after transient stretching." [GOC:jid, PMID:10841810, PMID:12615674] synonym: "elastic fibre assembly" EXACT [] synonym: "elastin fiber assembly" EXACT [GOC:BHF] synonym: "elastin fibre assembly" EXACT [GOC:BHF] is_a: GO:0085029 ! extracellular matrix assembly is_a: GO:0097435 ! supramolecular fiber organization intersection_of: GO:0022607 ! cellular component assembly intersection_of: RO:0002588 GO:0071953 ! results in assembly of elastic fiber relationship: RO:0002588 GO:0071953 ! results in assembly of elastic fiber [Term] id: GO:0048280 name: vesicle fusion with Golgi apparatus namespace: biological_process def: "The joining of the lipid bilayer membrane around a vesicle to the lipid bilayer membrane around the Golgi." [GOC:jid] is_a: GO:0006906 ! vesicle fusion is_a: GO:0007030 ! Golgi organization intersection_of: GO:0009987 ! cellular process intersection_of: RO:0012008 GO:0005794 ! results in fusion of Golgi apparatus intersection_of: RO:0012008 GO:0031982 ! results in fusion of vesicle relationship: BFO:0000050 GO:0048193 ! part of Golgi vesicle transport relationship: RO:0012008 GO:0005794 ! results in fusion of Golgi apparatus relationship: RO:0012008 GO:0031982 ! results in fusion of vesicle [Term] id: GO:0048284 name: organelle fusion namespace: biological_process def: "The creation of a single organelle from two or more organelles." [GOC:jid] subset: goslim_pir subset: goslim_yeast is_a: GO:0006996 ! organelle organization intersection_of: GO:0009987 ! cellular process intersection_of: RO:0012008 GO:0043226 ! results in fusion of organelle relationship: RO:0012008 GO:0043226 ! results in fusion of organelle [Term] id: GO:0048285 name: organelle fission namespace: biological_process def: "The creation of two or more organelles by division of one organelle." [GOC:jid] subset: goslim_pir subset: goslim_yeast is_a: GO:0006996 ! organelle organization intersection_of: GO:0009987 ! cellular process intersection_of: results_in_fission_of GO:0043226 ! organelle relationship: results_in_fission_of GO:0043226 ! organelle [Term] id: GO:0048286 name: lung alveolus development namespace: biological_process def: "The process whose specific outcome is the progression of the alveolus over time, from its formation to the mature structure. The alveolus is a sac for holding air in the lungs; formed by the terminal dilation of air passageways." [GOC:mtg_lung, PMID:9751757] synonym: "alveolarization" EXACT [PMID:17911382] synonym: "alveologenesis" EXACT [GOC:17911382] is_a: GO:0048856 ! anatomical structure development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0002299 ! results in development of alveolus of lung relationship: BFO:0000050 GO:0030324 ! part of lung development relationship: RO:0002296 UBERON:0002299 ! results in development of alveolus of lung [Term] id: GO:0048288 name: nuclear membrane fusion involved in karyogamy namespace: biological_process def: "The joining of 2 or more lipid bilayer membranes that surround the nucleus during the creation of a single nucleus from multiple nuclei." [GOC:jid] synonym: "nuclear membrane fusion during karyogamy" RELATED [GOC:dph, GOC:tb] is_a: GO:0000740 ! nuclear membrane fusion intersection_of: GO:0000740 ! nuclear membrane fusion intersection_of: BFO:0000050 GO:0000741 ! part of karyogamy relationship: BFO:0000050 GO:0000741 ! part of karyogamy [Term] id: GO:0048289 name: isotype switching to IgE isotypes namespace: biological_process def: "The switching of activated B cells from IgM biosynthesis to IgE biosynthesis, accomplished through a recombination process involving an intrachromosomal deletion between switch regions that reside 5' of the IgM and IgE constant region gene segments in the immunoglobulin heavy chain locus." [ISBN:0781735149, PMID:12370374, PMID:2113175, PMID:9186655] synonym: "class switch recombination to IgE isotypes" EXACT [] synonym: "class switching to IgE isotypes" EXACT [] synonym: "isotype switch recombination to IgE isotypes" EXACT [] is_a: GO:0045190 ! isotype switching [Term] id: GO:0048293 name: regulation of isotype switching to IgE isotypes namespace: biological_process def: "Any process that modulates the frequency, rate or extent of isotype switching to IgE isotypes." [GOC:jid] synonym: "regulation of class switch recombination to IgE isotypes" EXACT [] synonym: "regulation of class switching to IgE isotypes" EXACT [] synonym: "regulation of isotype switch recombination to IgE isotypes" EXACT [] is_a: GO:0045191 ! regulation of isotype switching intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0048289 ! regulates isotype switching to IgE isotypes relationship: RO:0002211 GO:0048289 ! regulates isotype switching to IgE isotypes [Term] id: GO:0048294 name: negative regulation of isotype switching to IgE isotypes namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of isotype switching to IgE isotypes." [GOC:jid] synonym: "down regulation of isotype switching to IgE isotypes" EXACT [] synonym: "down-regulation of isotype switching to IgE isotypes" EXACT [] synonym: "downregulation of isotype switching to IgE isotypes" EXACT [] synonym: "inhibition of isotype switching to IgE isotypes" NARROW [] synonym: "negative regulation of class switch recombination to IgE isotypes" EXACT [] synonym: "negative regulation of class switching to IgE isotypes" EXACT [] synonym: "negative regulation of isotype switch recombination to IgE isotypes" EXACT [] is_a: GO:0045829 ! negative regulation of isotype switching is_a: GO:0048293 ! regulation of isotype switching to IgE isotypes intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0048289 ! negatively regulates isotype switching to IgE isotypes relationship: RO:0002212 GO:0048289 ! negatively regulates isotype switching to IgE isotypes [Term] id: GO:0048295 name: positive regulation of isotype switching to IgE isotypes namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of isotype switching to IgE isotypes." [GOC:jid] synonym: "activation of isotype switching to IgE isotypes" NARROW [] synonym: "positive regulation of class switch recombination to IgE isotypes" EXACT [] synonym: "positive regulation of class switching to IgE isotypes" EXACT [] synonym: "positive regulation of isotype switch recombination to IgE isotypes" EXACT [] synonym: "stimulation of isotype switching to IgE isotypes" NARROW [] synonym: "up regulation of isotype switching to IgE isotypes" EXACT [] synonym: "up-regulation of isotype switching to IgE isotypes" EXACT [] synonym: "upregulation of isotype switching to IgE isotypes" EXACT [] is_a: GO:0045830 ! positive regulation of isotype switching is_a: GO:0048293 ! regulation of isotype switching to IgE isotypes intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0048289 ! positively regulates isotype switching to IgE isotypes relationship: RO:0002213 GO:0048289 ! positively regulates isotype switching to IgE isotypes [Term] id: GO:0048306 name: calcium-dependent protein binding namespace: molecular_function def: "Binding to a protein or protein complex in the presence of calcium." [GOC:jid, PMID:10485905] is_a: GO:0005515 ! protein binding intersection_of: GO:0005515 ! protein binding intersection_of: BFO:0000051 GO:0005509 ! has part calcium ion binding relationship: BFO:0000051 GO:0005509 ! has part calcium ion binding [Term] id: GO:0048308 name: organelle inheritance namespace: biological_process def: "The partitioning of organelles between daughter cells at cell division." [GOC:jid] subset: goslim_pir subset: goslim_yeast is_a: GO:0006996 ! organelle organization [Term] id: GO:0048311 name: mitochondrion distribution namespace: biological_process def: "Any process that establishes the spatial arrangement of mitochondria between and within cells." [GOC:jid] synonym: "distribution of mitochondria" EXACT [] synonym: "mitochondrial distribution" EXACT [] synonym: "positioning of mitochondria" RELATED [] is_a: GO:0051646 ! mitochondrion localization property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/28919" xsd:anyURI [Term] id: GO:0048313 name: Golgi inheritance namespace: biological_process def: "The partitioning of Golgi apparatus between daughter cells at cell division." [GOC:jid, PMID:12851069] synonym: "Golgi apparatus inheritance" EXACT [] synonym: "Golgi division" EXACT [GOC:ascb_2009, GOC:dph, GOC:tb] synonym: "Golgi partitioning" EXACT [] xref: Reactome:R-HSA-162658 "Golgi Cisternae Pericentriolar Stack Reorganization" is_a: GO:0007030 ! Golgi organization is_a: GO:0048308 ! organelle inheritance intersection_of: GO:0048308 ! organelle inheritance intersection_of: results_in_distribution_of GO:0005794 ! Golgi apparatus relationship: results_in_distribution_of GO:0005794 ! Golgi apparatus [Term] id: GO:0048318 name: axial mesoderm development namespace: biological_process def: "The process whose specific outcome is the progression of the axial mesoderm over time, from its formation to the mature structure. The axial mesoderm includes the prechordal mesoderm and the chordamesoderm. It gives rise to the prechordal plate and to the notochord." [GOC:dgh] is_a: GO:0007498 ! mesoderm development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0003068 ! results in development of axial mesoderm relationship: RO:0002296 UBERON:0003068 ! results in development of axial mesoderm [Term] id: GO:0048319 name: axial mesoderm morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the axial mesoderm are generated and organized." [GOC:go_curators] is_a: GO:0048332 ! mesoderm morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0003068 ! results in morphogenesis of axial mesoderm relationship: BFO:0000050 GO:0048318 ! part of axial mesoderm development relationship: RO:0002298 UBERON:0003068 ! results in morphogenesis of axial mesoderm [Term] id: GO:0048320 name: axial mesoderm formation namespace: biological_process def: "The process that gives rise to the axial mesoderm. This process pertains to the initial formation of the structure from unspecified parts." [GOC:dgh] xref: Reactome:R-HSA-9796292 "Formation of axial mesoderm" is_a: GO:0001707 ! mesoderm formation intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0003068 ! results in formation of anatomical entity axial mesoderm relationship: BFO:0000050 GO:0048319 ! part of axial mesoderm morphogenesis relationship: RO:0002297 UBERON:0003068 ! results in formation of anatomical entity axial mesoderm [Term] id: GO:0048332 name: mesoderm morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the mesoderm are generated and organized." [GOC:go_curators] is_a: GO:0048729 ! tissue morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0000926 ! results in morphogenesis of mesoderm relationship: BFO:0000050 GO:0007498 ! part of mesoderm development relationship: RO:0002298 UBERON:0000926 ! results in morphogenesis of mesoderm [Term] id: GO:0048333 name: mesodermal cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires the specialized features of a mesoderm cell." [GOC:dgh] synonym: "mesoderm cell differentiation" EXACT [] is_a: GO:0030154 ! cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000222 ! results in acquisition of features of mesodermal cell relationship: BFO:0000050 GO:0001707 ! part of mesoderm formation relationship: RO:0002315 CL:0000222 ! results in acquisition of features of mesodermal cell [Term] id: GO:0048339 name: paraxial mesoderm development namespace: biological_process def: "The process whose specific outcome is the progression of the paraxial mesoderm over time, from its formation to the mature structure. The paraxial mesoderm is the mesoderm located bilaterally adjacent to the notochord and neural tube." [GOC:dgh] is_a: GO:0007498 ! mesoderm development is_a: GO:0060485 ! mesenchyme development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0003077 ! results in development of paraxial mesoderm relationship: RO:0002296 UBERON:0003077 ! results in development of paraxial mesoderm [Term] id: GO:0048340 name: paraxial mesoderm morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the paraxial mesoderm are generated and organized." [GOC:go_curators] is_a: GO:0048332 ! mesoderm morphogenesis is_a: GO:0072132 ! mesenchyme morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0003077 ! results in morphogenesis of paraxial mesoderm relationship: BFO:0000050 GO:0048339 ! part of paraxial mesoderm development relationship: RO:0002298 UBERON:0003077 ! results in morphogenesis of paraxial mesoderm [Term] id: GO:0048341 name: paraxial mesoderm formation namespace: biological_process def: "The process that gives rise to the paraxial mesoderm. This process pertains to the initial formation of the structure from unspecified parts." [GOC:dgh] xref: Reactome:R-HSA-9793380 "Formation of paraxial mesoderm" is_a: GO:0001707 ! mesoderm formation intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0003077 ! results in formation of anatomical entity paraxial mesoderm relationship: BFO:0000050 GO:0048340 ! part of paraxial mesoderm morphogenesis relationship: RO:0002297 UBERON:0003077 ! results in formation of anatomical entity paraxial mesoderm [Term] id: GO:0048368 name: lateral mesoderm development namespace: biological_process def: "The process whose specific outcome is the progression of the lateral mesoderm over time, from its formation to the mature structure." [GOC:go_curators] synonym: "lateral plate mesoderm development" EXACT [] is_a: GO:0007498 ! mesoderm development is_a: GO:0060485 ! mesenchyme development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0003081 ! results in development of lateral plate mesoderm relationship: RO:0002296 UBERON:0003081 ! results in development of lateral plate mesoderm [Term] id: GO:0048369 name: lateral mesoderm morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the lateral mesoderm are generated and organized." [GOC:go_curators] synonym: "lateral plate mesoderm morphogenesis" EXACT [] is_a: GO:0048332 ! mesoderm morphogenesis is_a: GO:0072132 ! mesenchyme morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0003081 ! results in morphogenesis of lateral plate mesoderm relationship: BFO:0000050 GO:0048368 ! part of lateral mesoderm development relationship: RO:0002298 UBERON:0003081 ! results in morphogenesis of lateral plate mesoderm [Term] id: GO:0048370 name: lateral mesoderm formation namespace: biological_process def: "The process that gives rise to the lateral mesoderm. This process pertains to the initial formation of the structure from unspecified parts." [GOC:jid] synonym: "lateral plate mesoderm biosynthesis" EXACT [] synonym: "lateral plate mesoderm formation" EXACT [] xref: Reactome:R-HSA-9758920 "Formation of lateral plate mesoderm" is_a: GO:0001707 ! mesoderm formation intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002298 UBERON:0003081 ! results in morphogenesis of lateral plate mesoderm relationship: BFO:0000050 GO:0048369 ! part of lateral mesoderm morphogenesis relationship: RO:0002298 UBERON:0003081 ! results in morphogenesis of lateral plate mesoderm [Term] id: GO:0048389 name: intermediate mesoderm development namespace: biological_process def: "The process whose specific outcome is the progression of the intermediate mesoderm over time, from its formation to the mature structure. The intermediate mesoderm is located between the lateral mesoderm and the paraxial mesoderm. It develops into the kidney and gonads." [GOC:dgh] is_a: GO:0007498 ! mesoderm development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0003064 ! results in development of intermediate mesoderm relationship: RO:0002296 UBERON:0003064 ! results in development of intermediate mesoderm [Term] id: GO:0048390 name: intermediate mesoderm morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the intermediate mesoderm are generated and organized." [GOC:go_curators] is_a: GO:0048332 ! mesoderm morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0003064 ! results in morphogenesis of intermediate mesoderm relationship: BFO:0000050 GO:0048389 ! part of intermediate mesoderm development relationship: RO:0002298 UBERON:0003064 ! results in morphogenesis of intermediate mesoderm [Term] id: GO:0048391 name: intermediate mesoderm formation namespace: biological_process def: "The process that gives rise to the intermediate mesoderm. This process pertains to the initial formation of the structure from unspecified parts." [GOC:dgh] xref: Reactome:R-HSA-9761174 "Formation of intermediate mesoderm" is_a: GO:0001707 ! mesoderm formation intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0003064 ! results in formation of anatomical entity intermediate mesoderm relationship: BFO:0000050 GO:0048390 ! part of intermediate mesoderm morphogenesis relationship: RO:0002297 UBERON:0003064 ! results in formation of anatomical entity intermediate mesoderm [Term] id: GO:0048468 name: cell development namespace: biological_process def: "The cellular developmental process in which a specific cell progresses from an immature to a mature state. Cell development start once cell commitment has taken place." [GOC:go_curators] subset: goslim_candida synonym: "terminal differentiation" RELATED [GOC:dph, GOC:tb] is_a: GO:0048856 ! anatomical structure development is_a: GO:0048869 ! cellular developmental process intersection_of: GO:0008150 ! biological_process intersection_of: RO:0002296 CL:0000000 ! results in development of cell relationship: BFO:0000050 GO:0030154 ! part of cell differentiation relationship: RO:0002296 CL:0000000 ! results in development of cell property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/24390" xsd:anyURI [Term] id: GO:0048469 name: cell maturation namespace: biological_process def: "The cellular developmental process, independent of morphogenetic (shape) change, that is required for a specific cell to attain its fully functional state." [GOC:go_curators] subset: goslim_pir synonym: "functional differentiation" RELATED [GOC:dph] is_a: GO:0048869 ! cellular developmental process is_a: GO:0071695 ! anatomical structure maturation intersection_of: GO:0021700 ! developmental maturation intersection_of: RO:0002299 CL:0000000 ! results in maturation of cell relationship: BFO:0000050 GO:0048468 ! part of cell development relationship: RO:0002299 CL:0000000 ! results in maturation of cell property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/24390" xsd:anyURI [Term] id: GO:0048477 name: oogenesis namespace: biological_process def: "The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster." [GOC:kmv, GOC:mtg_sensu, GOC:pr] synonym: "ovum development" EXACT systematic_synonym [] xref: Wikipedia:Oogenesis is_a: GO:0007281 ! germ cell development is_a: GO:0007292 ! female gamete generation intersection_of: GO:0048468 ! cell development intersection_of: RO:0002296 CL:0000025 ! results in development of egg cell relationship: RO:0002296 CL:0000025 ! results in development of egg cell [Term] id: GO:0048483 name: autonomic nervous system development namespace: biological_process def: "The process whose specific outcome is the progression of the autonomic nervous system over time, from its formation to the mature structure. The autonomic nervous system is composed of neurons that are not under conscious control, and is comprised of two antagonistic components, the sympathetic and parasympathetic nervous systems. The autonomic nervous system regulates key functions including the activity of the cardiac (heart) muscle, smooth muscles (e.g. of the gut), and glands." [FMA:9905, GOC:jid, GOC:sr] is_a: GO:0048731 ! system development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0002410 ! results in development of autonomic nervous system relationship: BFO:0000050 GO:0007399 ! part of nervous system development relationship: RO:0002296 UBERON:0002410 ! results in development of autonomic nervous system [Term] id: GO:0048484 name: enteric nervous system development namespace: biological_process def: "The process whose specific outcome is the progression of the enteric nervous system over time, from its formation to the mature structure. The enteric nervous system is composed of two ganglionated neural plexuses in the gut wall which form one of the three major divisions of the autonomic nervous system. The enteric nervous system innervates the gastrointestinal tract, the pancreas, and the gallbladder. It contains sensory neurons, interneurons, and motor neurons. Thus the circuitry can autonomously sense the tension and the chemical environment in the gut and regulate blood vessel tone, motility, secretions, and fluid transport. The system is itself governed by the central nervous system and receives both parasympathetic and sympathetic innervation." [FMA:66070, GOC:jid, GOC:sr] is_a: GO:0048731 ! system development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0002005 ! results in development of enteric nervous system relationship: BFO:0000050 GO:0048483 ! part of autonomic nervous system development relationship: RO:0002296 UBERON:0002005 ! results in development of enteric nervous system [Term] id: GO:0048485 name: sympathetic nervous system development namespace: biological_process def: "The process whose specific outcome is the progression of the sympathetic nervous system over time, from its formation to the mature structure. The sympathetic nervous system is one of the two divisions of the vertebrate autonomic nervous system (the other being the parasympathetic nervous system). The sympathetic preganglionic neurons have their cell bodies in the thoracic and lumbar regions of the spinal cord and connect to the paravertebral chain of sympathetic ganglia. Innervate heart and blood vessels, sweat glands, viscera and the adrenal medulla. Most sympathetic neurons, but not all, use noradrenaline as a post-ganglionic neurotransmitter." [FMA:9906, GOC:jid, GOC:sr] is_a: GO:0048731 ! system development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0000013 ! results in development of sympathetic nervous system relationship: BFO:0000050 GO:0048483 ! part of autonomic nervous system development relationship: RO:0002296 UBERON:0000013 ! results in development of sympathetic nervous system [Term] id: GO:0048486 name: parasympathetic nervous system development namespace: biological_process def: "The process whose specific outcome is the progression of the parasympathetic nervous system over time, from its formation to the mature structure. The parasympathetic nervous system is one of the two divisions of the vertebrate autonomic nervous system. Parasympathetic nerves emerge cranially as pre ganglionic fibers from oculomotor, facial, glossopharyngeal and vagus and from the sacral region of the spinal cord. Most neurons are cholinergic and responses are mediated by muscarinic receptors. The parasympathetic system innervates, for example: salivary glands, thoracic and abdominal viscera, bladder and genitalia." [FMA:9907, GOC:jid, GOC:sr] is_a: GO:0048731 ! system development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0000011 ! results in development of parasympathetic nervous system relationship: BFO:0000050 GO:0048483 ! part of autonomic nervous system development relationship: RO:0002296 UBERON:0000011 ! results in development of parasympathetic nervous system [Term] id: GO:0048505 name: regulation of timing of cell differentiation namespace: biological_process def: "The process controlling the activation and/or rate at which relatively unspecialized cells acquire specialized features. Any process that modulates the rate, frequency or extent of the XXX at a consistent predetermined time point during its development." [GOC:bf, GOC:dph, GOC:jid, GOC:tb] synonym: "timing of cell differentiation" RELATED [] is_a: GO:0040034 ! regulation of development, heterochronic is_a: GO:0045595 ! regulation of cell differentiation [Term] id: GO:0048511 name: rhythmic process namespace: biological_process def: "Any process pertinent to the generation and maintenance of rhythms in the physiology of an organism." [GOC:jid] subset: goslim_pir synonym: "rhythm" RELATED [] is_a: GO:0008150 ! biological_process relationship: RO:0002162 NCBITaxon:131567 ! in taxon cellular organisms [Term] id: GO:0048513 name: animal organ development namespace: biological_process def: "Development of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions." [GOC:dph, GOC:jid] synonym: "development of an organ" EXACT [] synonym: "organogenesis" EXACT [] xref: Wikipedia:Organogenesis is_a: GO:0048856 ! anatomical structure development property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/25943" xsd:anyURI [Term] id: GO:0048514 name: blood vessel morphogenesis namespace: biological_process def: "The process in which the anatomical structures of blood vessels are generated and organized. The blood vessel is the vasculature carrying blood." [GOC:jid] is_a: GO:0035239 ! tube morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0001981 ! results in morphogenesis of blood vessel relationship: BFO:0000050 GO:0001568 ! part of blood vessel development relationship: RO:0002298 UBERON:0001981 ! results in morphogenesis of blood vessel [Term] id: GO:0048515 name: spermatid differentiation namespace: biological_process def: "The process whose specific outcome is the progression of a spermatid over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell." [GOC:dph, GOC:jid] synonym: "spermatid cell differentiation" EXACT [] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism is_a: GO:0030154 ! cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000018 ! results in acquisition of features of spermatid relationship: BFO:0000050 GO:0007283 ! part of spermatogenesis relationship: RO:0002315 CL:0000018 ! results in acquisition of features of spermatid property_value: RO:0002161 NCBITaxon:3176 property_value: RO:0002161 NCBITaxon:3378 property_value: RO:0002161 NCBITaxon:3398 property_value: RO:0002161 NCBITaxon:4751 property_value: RO:0002161 NCBITaxon:5782 [Term] id: GO:0048518 name: positive regulation of biological process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule." [GOC:jid] subset: gocheck_do_not_annotate synonym: "activation of biological process" NARROW [] synonym: "positive regulation of physiological process" EXACT [] synonym: "stimulation of biological process" NARROW [] synonym: "up regulation of biological process" EXACT [] synonym: "up-regulation of biological process" EXACT [] synonym: "upregulation of biological process" EXACT [] is_a: GO:0050789 ! regulation of biological process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0008150 ! positively regulates biological_process relationship: RO:0002213 GO:0008150 ! positively regulates biological_process [Term] id: GO:0048519 name: negative regulation of biological process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule." [GOC:jid] subset: gocheck_do_not_annotate synonym: "down regulation of biological process" EXACT [] synonym: "down-regulation of biological process" EXACT [] synonym: "downregulation of biological process" EXACT [] synonym: "inhibition of biological process" NARROW [] synonym: "negative regulation of physiological process" EXACT [] is_a: GO:0050789 ! regulation of biological process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0008150 ! negatively regulates biological_process relationship: RO:0002212 GO:0008150 ! negatively regulates biological_process [Term] id: GO:0048520 name: positive regulation of behavior namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of behavior, the internally coordinated responses (actions or inactions) of whole living organisms (individuals or groups) to internal or external stimuli." [GOC:jid, GOC:pr] synonym: "activation of behavior" NARROW [] synonym: "stimulation of behavior" NARROW [] synonym: "up regulation of behavior" EXACT [] synonym: "up-regulation of behavior" EXACT [] synonym: "upregulation of behavior" EXACT [] is_a: GO:0050795 ! regulation of behavior is_a: GO:0051240 ! positive regulation of multicellular organismal process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0007610 ! positively regulates behavior relationship: RO:0002213 GO:0007610 ! positively regulates behavior [Term] id: GO:0048521 name: negative regulation of behavior namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of behavior, the internally coordinated responses (actions or inactions) of whole living organisms (individuals or groups) to internal or external stimuli." [GOC:jid, GOC:pr] synonym: "down regulation of behavior" EXACT [] synonym: "down-regulation of behavior" EXACT [] synonym: "downregulation of behavior" EXACT [] synonym: "inhibition of behavior" NARROW [] is_a: GO:0050795 ! regulation of behavior is_a: GO:0051241 ! negative regulation of multicellular organismal process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0007610 ! negatively regulates behavior relationship: RO:0002212 GO:0007610 ! negatively regulates behavior [Term] id: GO:0048522 name: positive regulation of cellular process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:jid] subset: gocheck_do_not_annotate synonym: "activation of cellular process" NARROW [] synonym: "positive regulation of cellular physiological process" EXACT [] synonym: "stimulation of cellular process" NARROW [] synonym: "up regulation of cellular process" EXACT [] synonym: "up-regulation of cellular process" EXACT [] synonym: "upregulation of cellular process" EXACT [] is_a: GO:0048518 ! positive regulation of biological process is_a: GO:0050794 ! regulation of cellular process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0009987 ! positively regulates cellular process relationship: RO:0002213 GO:0009987 ! positively regulates cellular process [Term] id: GO:0048523 name: negative regulation of cellular process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:jid] subset: gocheck_do_not_annotate synonym: "down regulation of cellular process" EXACT [] synonym: "down-regulation of cellular process" EXACT [] synonym: "downregulation of cellular process" EXACT [] synonym: "inhibition of cellular process" NARROW [] synonym: "negative regulation of cellular physiological process" EXACT [] is_a: GO:0048519 ! negative regulation of biological process is_a: GO:0050794 ! regulation of cellular process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0009987 ! negatively regulates cellular process relationship: RO:0002212 GO:0009987 ! negatively regulates cellular process [Term] id: GO:0048534 name: hematopoietic or lymphoid organ development namespace: biological_process def: "The process whose specific outcome is the progression of any organ involved in hematopoiesis (also known as hemopoiesis) or lymphoid cell activation over time, from its formation to the mature structure. Such development includes differentiation of resident cell types (stromal cells) and of migratory cell types dependent on the unique microenvironment afforded by the organ for their proper differentiation." [GOC:add, GOC:rl, ISBN:0781735149] synonym: "haematopoietic or lymphoid organ development" EXACT [] synonym: "haemopoietic or lymphoid organ development" EXACT [] synonym: "hemopoietic or lymphoid organ development" EXACT [] is_a: GO:0048513 ! animal organ development relationship: BFO:0000050 GO:0002520 ! part of immune system development property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4895 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0048535 name: lymph node development namespace: biological_process def: "The process whose specific outcome is the progression of lymph nodes over time, from their formation to the mature structure. A lymph node is a round, oval, or bean shaped structure localized in clusters along the lymphatic vessels, with a distinct internal structure including specialized vasculature and B- and T-zones for the activation of lymphocytes." [GOC:add, ISBN:068340007X, ISBN:0781735149] synonym: "lymph gland development" BROAD [] is_a: GO:0048534 ! hematopoietic or lymphoid organ development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0000029 ! results in development of lymph node relationship: RO:0002162 NCBITaxon:40674 ! in taxon Mammalia relationship: RO:0002296 UBERON:0000029 ! results in development of lymph node [Term] id: GO:0048536 name: spleen development namespace: biological_process def: "The process whose specific outcome is the progression of the spleen over time, from its formation to the mature structure. The spleen is a large vascular lymphatic organ composed of white and red pulp, involved both in hemopoietic and immune system functions." [GOC:add, ISBN:0781735149] is_a: GO:0048534 ! hematopoietic or lymphoid organ development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0002106 ! results in development of spleen relationship: RO:0002296 UBERON:0002106 ! results in development of spleen [Term] id: GO:0048537 name: mucosa-associated lymphoid tissue development namespace: biological_process def: "The process whose specific outcome is the progression of mucosal-associated lymphoid tissue over time, from its formation to the mature structure. Mucosal-associated lymphoid tissue is typically found as nodules associated with mucosal epithelia with distinct internal structures including B- and T-zones for the activation of lymphocytes." [GOC:add, ISBN:0781735149] synonym: "BALT development" NARROW [] synonym: "bronchial-associated lymphoid tissue development" NARROW [] synonym: "GALT development" NARROW [] synonym: "gut-associated lymphoid tissue development" NARROW [] synonym: "mucosal-associated lymphoid tissue development" EXACT [] synonym: "NALT development" NARROW [] synonym: "nasopharyngeal-associated lymphoid tissue development" NARROW [] is_a: GO:0009888 ! tissue development is_a: GO:0048534 ! hematopoietic or lymphoid organ development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0001961 ! results in development of mucosa-associated lymphoid tissue relationship: RO:0002296 UBERON:0001961 ! results in development of mucosa-associated lymphoid tissue property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/19918" xsd:anyURI [Term] id: GO:0048538 name: thymus development namespace: biological_process def: "The process whose specific outcome is the progression of the thymus over time, from its formation to the mature structure. The thymus is a symmetric bi-lobed organ involved primarily in the differentiation of immature to mature T cells, with unique vascular, nervous, epithelial, and lymphoid cell components." [GOC:add, ISBN:0781735149] comment: Note that this term is reserved for annotation of gene products involved in the formation of the thymus itself, not for gene products involved in T cell differentiation in the thymus or elsewhere. is_a: GO:0048534 ! hematopoietic or lymphoid organ development is_a: GO:0048732 ! gland development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0002370 ! results in development of thymus relationship: RO:0002162 NCBITaxon:7776 ! in taxon Gnathostomata relationship: RO:0002296 UBERON:0002370 ! results in development of thymus [Term] id: GO:0048539 name: bone marrow development namespace: biological_process def: "The process whose specific outcome is the progression of the bone marrow over time, from its formation to the mature structure." [GOC:add, ISBN:0781735149] is_a: GO:0009888 ! tissue development is_a: GO:0048534 ! hematopoietic or lymphoid organ development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0002371 ! results in development of bone marrow relationship: BFO:0000050 GO:0060348 ! part of bone development relationship: RO:0002296 UBERON:0002371 ! results in development of bone marrow [Term] id: GO:0048541 name: Peyer's patch development namespace: biological_process def: "The process whose specific outcome is the progression of Peyer's patches over time, from their formation to the mature structure. Peyer's patches are typically found as nodules associated with gut epithelium with distinct internal structures including B- and T-zones for the activation of lymphocytes." [GOC:add, ISBN:0781735149] synonym: "GALT development" RELATED [] synonym: "gut-associated lymphoid tissue development" RELATED [] is_a: GO:0048537 ! mucosa-associated lymphoid tissue development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0001211 ! results in development of Peyer's patch relationship: RO:0002296 UBERON:0001211 ! results in development of Peyer's patch [Term] id: GO:0048542 name: lymph gland development namespace: biological_process def: "The process whose specific outcome is the progression of the lymph gland over time, from its formation to the mature structure. The lymph gland is one of the sites of hemocyte differentiation. It consists of three to six bilaterally paired lobes that are attached to the cardioblasts during larval stages, and it degenerates during pupal stages." [GOC:mtg_sensu, GOC:rc] synonym: "haematopoietic organ development" BROAD [] synonym: "haemopoietic organ development" BROAD [] synonym: "hematopoietic organ development" BROAD [] synonym: "hemopoietic organ development" BROAD [] is_a: GO:0048534 ! hematopoietic or lymphoid organ development is_a: GO:0048732 ! gland development relationship: RO:0002162 NCBITaxon:6656 ! in taxon Arthropoda [Term] id: GO:0048545 name: response to steroid hormone namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a steroid hormone stimulus." [GOC:go_curators] synonym: "response to steroid hormone stimulus" EXACT [GOC:dos] is_a: GO:0009725 ! response to hormone is_a: GO:0033993 ! response to lipid intersection_of: GO:0050896 ! response to stimulus intersection_of: RO:0004009 CHEBI:26764 ! has primary input relationship: RO:0004009 CHEBI:26764 ! has primary input property_value: RO:0002161 NCBITaxon:4751 [Term] id: GO:0048546 name: digestive tract morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the digestive tract are generated and organized. The digestive tract is the anatomical structure through which food passes and is processed." [GOC:dph, GOC:go_curators, PMID:12618131] synonym: "alimentary canal morphogenesis" EXACT [] synonym: "digestive tube morphogenesis" EXACT [] synonym: "gastrointestinal tract morphogenesis" EXACT [] synonym: "gut morphogenesis" BROAD [GOC:dph] synonym: "intestinal morphogenesis" NARROW [] is_a: GO:0035239 ! tube morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0001555 ! results in morphogenesis of digestive tract relationship: BFO:0000050 GO:0048565 ! part of digestive tract development relationship: RO:0002298 UBERON:0001555 ! results in morphogenesis of digestive tract [Term] id: GO:0048562 name: embryonic organ morphogenesis namespace: biological_process def: "Morphogenesis, during the embryonic phase, of a tissue or tissues that work together to perform a specific function or functions. Morphogenesis is the process in which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions." [GOC:jid] is_a: GO:0009887 ! animal organ morphogenesis is_a: GO:0048598 ! embryonic morphogenesis relationship: BFO:0000050 GO:0048568 ! part of embryonic organ development [Term] id: GO:0048565 name: digestive tract development namespace: biological_process def: "The process whose specific outcome is the progression of the digestive tract over time, from its formation to the mature structure. The digestive tract is the anatomical structure through which food passes and is processed." [GOC:go_curators] synonym: "gut development" BROAD [GOC:dph] synonym: "intestinal development" NARROW [] synonym: "intestine development" NARROW [] is_a: GO:0035295 ! tube development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0001555 ! results in development of digestive tract relationship: BFO:0000050 GO:0055123 ! part of digestive system development relationship: RO:0002296 UBERON:0001555 ! results in development of digestive tract [Term] id: GO:0048568 name: embryonic organ development namespace: biological_process def: "Development, taking place during the embryonic phase, of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions." [GOC:jid] synonym: "embryonic organogenesis" EXACT [] is_a: GO:0048513 ! animal organ development intersection_of: GO:0048856 ! anatomical structure development intersection_of: BFO:0000050 GO:0009790 ! part of embryo development intersection_of: RO:0002296 UBERON:0000062 ! results in development of organ relationship: BFO:0000050 GO:0009790 ! part of embryo development relationship: RO:0002296 UBERON:0000062 ! results in development of organ property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0048570 name: notochord morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the notochord are generated and organized. The notochord is a mesoderm-derived structure located ventral of the developing nerve cord. In vertebrates, the notochord serves as a core around which other mesodermal cells form the vertebrae. In the most primitive chordates, which lack vertebrae, the notochord persists as a substitute for a vertebral column." [GOC:jid] is_a: GO:0048562 ! embryonic organ morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0002328 ! results in morphogenesis of notochord relationship: BFO:0000050 GO:0030903 ! part of notochord development relationship: RO:0002298 UBERON:0002328 ! results in morphogenesis of notochord [Term] id: GO:0048580 name: regulation of post-embryonic development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of post-embryonic development. Post-embryonic development is defined as the process whose specific outcome is the progression of the organism over time, from the completion of embryonic development to the mature structure." [GOC:jid] is_a: GO:2000026 ! regulation of multicellular organismal development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0009791 ! regulates post-embryonic development relationship: RO:0002211 GO:0009791 ! regulates post-embryonic development property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0048581 name: negative regulation of post-embryonic development namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of post-embryonic development. Post-embryonic development is defined as the process whose specific outcome is the progression of the organism over time, from the completion of embryonic development to the mature structure." [GOC:jid] synonym: "down regulation of post-embryonic development" EXACT [] synonym: "down-regulation of post-embryonic development" EXACT [] synonym: "downregulation of post-embryonic development" EXACT [] synonym: "inhibition of post-embryonic development" NARROW [] is_a: GO:0048580 ! regulation of post-embryonic development is_a: GO:0051093 ! negative regulation of developmental process is_a: GO:0051241 ! negative regulation of multicellular organismal process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0009791 ! negatively regulates post-embryonic development relationship: RO:0002212 GO:0009791 ! negatively regulates post-embryonic development property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0048582 name: positive regulation of post-embryonic development namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of post-embryonic development. Post-embryonic development is defined as the process whose specific outcome is the progression of the organism over time, from the completion of embryonic development to the mature structure." [GOC:jid] synonym: "activation of post-embryonic development" NARROW [] synonym: "stimulation of post-embryonic development" NARROW [] synonym: "up regulation of post-embryonic development" EXACT [] synonym: "up-regulation of post-embryonic development" EXACT [] synonym: "upregulation of post-embryonic development" EXACT [] is_a: GO:0048580 ! regulation of post-embryonic development is_a: GO:0051094 ! positive regulation of developmental process is_a: GO:0051240 ! positive regulation of multicellular organismal process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0009791 ! positively regulates post-embryonic development relationship: RO:0002213 GO:0009791 ! positively regulates post-embryonic development property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0048583 name: regulation of response to stimulus namespace: biological_process def: "Any process that modulates the frequency, rate or extent of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus." [GOC:jid] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_annotate is_a: GO:0050789 ! regulation of biological process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0050896 ! regulates response to stimulus relationship: RO:0002211 GO:0050896 ! regulates response to stimulus [Term] id: GO:0048584 name: positive regulation of response to stimulus namespace: biological_process def: "Any process that activates, maintains or increases the rate of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus." [GOC:jid] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_annotate synonym: "activation of response to stimulus" NARROW [] synonym: "stimulation of response to stimulus" NARROW [] synonym: "up regulation of response to stimulus" EXACT [] synonym: "up-regulation of response to stimulus" EXACT [] synonym: "upregulation of response to stimulus" EXACT [] is_a: GO:0048518 ! positive regulation of biological process is_a: GO:0048583 ! regulation of response to stimulus intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0050896 ! positively regulates response to stimulus relationship: RO:0002213 GO:0050896 ! positively regulates response to stimulus [Term] id: GO:0048585 name: negative regulation of response to stimulus namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus." [GOC:jid] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_annotate synonym: "down regulation of response to stimulus" EXACT [] synonym: "down-regulation of response to stimulus" EXACT [] synonym: "downregulation of response to stimulus" EXACT [] synonym: "inhibition of response to stimulus" NARROW [] is_a: GO:0048519 ! negative regulation of biological process is_a: GO:0048583 ! regulation of response to stimulus intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0050896 ! negatively regulates response to stimulus relationship: RO:0002212 GO:0050896 ! negatively regulates response to stimulus [Term] id: GO:0048588 name: developmental cell growth namespace: biological_process def: "The growth of a cell, where growth contributes to the progression of the cell over time from one condition to another." [GOC:go_curators, GOC:isa_complete] subset: gocheck_do_not_annotate synonym: "developmental growth of a unicellular organism" EXACT [] is_a: GO:0016049 ! cell growth is_a: GO:0048589 ! developmental growth relationship: BFO:0000050 GO:0048468 ! part of cell development property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/26424" xsd:anyURI [Term] id: GO:0048589 name: developmental growth namespace: biological_process def: "The increase in size or mass of an entire organism, a part of an organism or a cell, where the increase in size or mass has the specific outcome of the progression of the organism over time from one condition to another." [GOC:go_curators] is_a: GO:0040007 ! growth intersection_of: GO:0040007 ! growth intersection_of: BFO:0000050 GO:0032502 ! part of developmental process relationship: BFO:0000050 GO:0032502 ! part of developmental process [Term] id: GO:0048592 name: eye morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the eye are generated and organized." [GOC:jid, GOC:mtg_sensu] is_a: GO:0090596 ! sensory organ morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0000970 ! results in morphogenesis of eye relationship: BFO:0000050 GO:0001654 ! part of eye development relationship: RO:0002298 UBERON:0000970 ! results in morphogenesis of eye [Term] id: GO:0048593 name: camera-type eye morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the eye are generated and organized. The camera-type eye is an organ of sight that receives light through an aperture and focuses it through a lens, projecting it on a photoreceptor field." [GOC:jid, GOC:mtg_sensu] synonym: "camera-style eye morphogenesis" EXACT [GOC:dph] is_a: GO:0048592 ! eye morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0000019 ! results in morphogenesis of camera-type eye relationship: BFO:0000050 GO:0043010 ! part of camera-type eye development relationship: RO:0002298 UBERON:0000019 ! results in morphogenesis of camera-type eye [Term] id: GO:0048596 name: embryonic camera-type eye morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the eye are generated and organized during embryonic development." [GOC:jid, GOC:mtg_sensu] synonym: "embryonic eye morphogenesis" BROAD [] is_a: GO:0048048 ! embryonic eye morphogenesis relationship: BFO:0000050 GO:0031076 ! part of embryonic camera-type eye development relationship: BFO:0000050 GO:0048593 ! part of camera-type eye morphogenesis [Term] id: GO:0048598 name: embryonic morphogenesis namespace: biological_process def: "The process in which anatomical structures are generated and organized during the embryonic phase. The embryonic phase begins with zygote formation. The end of the embryonic phase is organism-specific. For example, it would be at birth for mammals, larval hatching for insects and seed dormancy in plants." [GOC:jid, GOC:mtg_sensu] synonym: "embryonic anatomical structure morphogenesis" EXACT [GOC:dph, GOC:tb] is_a: GO:0009653 ! anatomical structure morphogenesis relationship: BFO:0000050 GO:0009790 ! part of embryo development property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0048599 name: oocyte development namespace: biological_process def: "The process whose specific outcome is the progression of an oocyte over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell." [GOC:go_curators] is_a: GO:0007281 ! germ cell development intersection_of: GO:0032502 ! developmental process intersection_of: RO:0002296 CL:0000023 ! results in development of oocyte relationship: BFO:0000050 GO:0009994 ! part of oocyte differentiation relationship: RO:0002296 CL:0000023 ! results in development of oocyte [Term] id: GO:0048601 name: oocyte morphogenesis namespace: biological_process def: "The process in which the structures of an oocyte are generated and organized. This process occurs while the initially relatively unspecialized cell is acquiring the specialized features of an oocyte." [GOC:go_curators] synonym: "oocyte morphogenesis during differentiation" EXACT [] is_a: GO:0000902 ! cell morphogenesis is_a: GO:0003006 ! developmental process involved in reproduction intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 CL:0000023 ! results in morphogenesis of oocyte relationship: BFO:0000050 GO:0048599 ! part of oocyte development relationship: RO:0002298 CL:0000023 ! results in morphogenesis of oocyte [Term] id: GO:0048608 name: reproductive structure development namespace: biological_process def: "The reproductive developmental process whose specific outcome is the progression of somatic structures that will be used in the process of creating new individuals from one or more parents, from their formation to the mature structures." [GOC:dph, GOC:isa_complete, GOC:jid] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0048856 ! anatomical structure development relationship: BFO:0000050 GO:0061458 ! part of reproductive system development property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/23445" xsd:anyURI property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0048609 name: multicellular organismal reproductive process namespace: biological_process def: "The process, occurring above the cellular level, that is pertinent to the reproductive function of a multicellular organism. This includes the integrated processes at the level of tissues and organs." [GOC:dph, GOC:jid, GOC:tb] subset: gocheck_do_not_annotate subset: goslim_drosophila synonym: "organismal reproductive process" BROAD [] synonym: "reproductive process in a multicellular organism" EXACT [] xref: Reactome:R-HSA-1474165 "Reproduction" is_a: GO:0022414 ! reproductive process property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/27054" xsd:anyURI [Term] id: GO:0048619 name: embryonic hindgut morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the hindgut are generated and organized, during the embryonic phase." [GOC:jid, GOC:rc] is_a: GO:0048598 ! embryonic morphogenesis relationship: BFO:0000050 GO:0007442 ! part of hindgut morphogenesis [Term] id: GO:0048627 name: myoblast development namespace: biological_process def: "The process whose specific outcome is the progression of the myoblast over time, from its formation to the mature structure. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers." [CL:0000056, GOC:dph, GOC:mtg_muscle] is_a: GO:0048468 ! cell development intersection_of: GO:0032502 ! developmental process intersection_of: RO:0002296 CL:0000056 ! results in development of myoblast relationship: BFO:0000050 GO:0045445 ! part of myoblast differentiation relationship: RO:0002296 CL:0000056 ! results in development of myoblast [Term] id: GO:0048628 name: myoblast maturation namespace: biological_process def: "A developmental process, independent of morphogenetic (shape) change, that is required for a myoblast to attain its fully functional state. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers." [CL:0000056, GOC:dph, GOC:mtg_muscle] is_a: GO:0048469 ! cell maturation intersection_of: GO:0021700 ! developmental maturation intersection_of: RO:0002299 CL:0000056 ! results in maturation of myoblast relationship: BFO:0000050 GO:0048627 ! part of myoblast development relationship: RO:0002299 CL:0000056 ! results in maturation of myoblast [Term] id: GO:0048630 name: skeletal muscle tissue growth namespace: biological_process def: "The increase in size or mass of a skeletal muscle. This may be due to a change in the fiber number or size." [GOC:lm, PMID:15726494, PMID:15907921] is_a: BFO:0000003 is_a: GO:0048589 ! developmental growth intersection_of: GO:0048589 ! developmental growth intersection_of: RO:0002343 UBERON:0001134 ! results in growth of skeletal muscle tissue relationship: BFO:0000050 GO:0007519 ! part of skeletal muscle tissue development relationship: RO:0002343 UBERON:0001134 ! results in growth of skeletal muscle tissue [Term] id: GO:0048631 name: regulation of skeletal muscle tissue growth namespace: biological_process def: "Any process that modulates the frequency, rate or extent of skeletal muscle growth." [GOC:lm, PMID:15726494, PMID:15907921] is_a: GO:0048638 ! regulation of developmental growth intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0048630 ! regulates skeletal muscle tissue growth relationship: RO:0002211 GO:0048630 ! regulates skeletal muscle tissue growth [Term] id: GO:0048632 name: negative regulation of skeletal muscle tissue growth namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of skeletal muscle growth." [GOC:lm, PMID:15726494, PMID:15907921] synonym: "down regulation of skeletal muscle growth" EXACT [] synonym: "down-regulation of skeletal muscle growth" EXACT [] synonym: "downregulation of skeletal muscle growth" EXACT [] synonym: "inhibition of skeletal muscle growth" NARROW [] is_a: GO:0048631 ! regulation of skeletal muscle tissue growth is_a: GO:0048640 ! negative regulation of developmental growth intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0048630 ! negatively regulates skeletal muscle tissue growth relationship: RO:0002212 GO:0048630 ! negatively regulates skeletal muscle tissue growth [Term] id: GO:0048633 name: positive regulation of skeletal muscle tissue growth namespace: biological_process def: "Any process that activates, maintains or increases the rate of skeletal muscle growth." [GOC:lm, PMID:15726494, PMID:15907921] synonym: "activation of skeletal muscle growth" NARROW [] synonym: "stimulation of skeletal muscle growth" NARROW [] synonym: "up regulation of skeletal muscle growth" EXACT [] synonym: "up-regulation of skeletal muscle growth" EXACT [] synonym: "upregulation of skeletal muscle growth" EXACT [] is_a: GO:0048631 ! regulation of skeletal muscle tissue growth is_a: GO:0048639 ! positive regulation of developmental growth is_a: GO:0048643 ! positive regulation of skeletal muscle tissue development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0048630 ! positively regulates skeletal muscle tissue growth relationship: RO:0002213 GO:0048630 ! positively regulates skeletal muscle tissue growth [Term] id: GO:0048634 name: regulation of muscle organ development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of muscle development." [GOC:go_curators] is_a: GO:0050793 ! regulation of developmental process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0007517 ! regulates muscle organ development relationship: RO:0002211 GO:0007517 ! regulates muscle organ development [Term] id: GO:0048635 name: negative regulation of muscle organ development namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of muscle development." [GOC:go_curators] synonym: "down regulation of muscle development" EXACT [] synonym: "down-regulation of muscle development" EXACT [] synonym: "downregulation of muscle development" EXACT [] synonym: "inhibition of muscle development" NARROW [] is_a: GO:0048634 ! regulation of muscle organ development is_a: GO:0051093 ! negative regulation of developmental process is_a: GO:0051241 ! negative regulation of multicellular organismal process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0007517 ! negatively regulates muscle organ development relationship: RO:0002212 GO:0007517 ! negatively regulates muscle organ development [Term] id: GO:0048636 name: positive regulation of muscle organ development namespace: biological_process def: "Any process that activates, maintains or increases the rate of muscle development." [GOC:go_curators] synonym: "activation of muscle development" NARROW [] synonym: "stimulation of muscle development" NARROW [] synonym: "up regulation of muscle development" EXACT [] synonym: "up-regulation of muscle development" EXACT [] synonym: "upregulation of muscle development" EXACT [] is_a: GO:0048634 ! regulation of muscle organ development is_a: GO:0051094 ! positive regulation of developmental process is_a: GO:0051240 ! positive regulation of multicellular organismal process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0007517 ! positively regulates muscle organ development relationship: RO:0002213 GO:0007517 ! positively regulates muscle organ development [Term] id: GO:0048638 name: regulation of developmental growth namespace: biological_process def: "Any process that modulates the frequency, rate or extent of developmental growth." [GOC:go_curators] is_a: GO:0040008 ! regulation of growth is_a: GO:0050793 ! regulation of developmental process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0048589 ! regulates developmental growth relationship: RO:0002211 GO:0048589 ! regulates developmental growth [Term] id: GO:0048639 name: positive regulation of developmental growth namespace: biological_process def: "Any process that activates, maintains or increases the rate of developmental growth." [GOC:go_curators] synonym: "activation of developmental growth" NARROW [] synonym: "stimulation of developmental growth" NARROW [] synonym: "up regulation of developmental growth" EXACT [] synonym: "up-regulation of developmental growth" EXACT [] synonym: "upregulation of developmental growth" EXACT [] is_a: GO:0045927 ! positive regulation of growth is_a: GO:0048638 ! regulation of developmental growth is_a: GO:0051094 ! positive regulation of developmental process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0048589 ! positively regulates developmental growth relationship: RO:0002213 GO:0048589 ! positively regulates developmental growth [Term] id: GO:0048640 name: negative regulation of developmental growth namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of developmental growth." [GOC:go_curators] synonym: "down regulation of developmental growth" EXACT [] synonym: "down-regulation of developmental growth" EXACT [] synonym: "downregulation of developmental growth" EXACT [] synonym: "inhibition of developmental growth" NARROW [] is_a: GO:0045926 ! negative regulation of growth is_a: GO:0048638 ! regulation of developmental growth is_a: GO:0051093 ! negative regulation of developmental process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0048589 ! negatively regulates developmental growth relationship: RO:0002212 GO:0048589 ! negatively regulates developmental growth [Term] id: GO:0048641 name: regulation of skeletal muscle tissue development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of skeletal muscle tissue development." [GOC:go_curators] is_a: GO:0016202 ! regulation of striated muscle tissue development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0007519 ! regulates skeletal muscle tissue development relationship: RO:0002211 GO:0007519 ! regulates skeletal muscle tissue development [Term] id: GO:0048642 name: negative regulation of skeletal muscle tissue development namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of skeletal muscle tissue development." [GOC:go_curators] synonym: "down regulation of skeletal muscle development" EXACT [] synonym: "down-regulation of skeletal muscle development" EXACT [] synonym: "downregulation of skeletal muscle development" EXACT [] synonym: "inhibition of skeletal muscle development" NARROW [] is_a: GO:0045843 ! negative regulation of striated muscle tissue development is_a: GO:0048641 ! regulation of skeletal muscle tissue development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0007519 ! negatively regulates skeletal muscle tissue development relationship: RO:0002212 GO:0007519 ! negatively regulates skeletal muscle tissue development [Term] id: GO:0048643 name: positive regulation of skeletal muscle tissue development namespace: biological_process def: "Any process that activates, maintains or increases the rate of skeletal muscle tissue development." [GOC:go_curators] synonym: "activation of skeletal muscle development" NARROW [] synonym: "stimulation of skeletal muscle development" NARROW [] synonym: "up regulation of skeletal muscle development" EXACT [] synonym: "up-regulation of skeletal muscle development" EXACT [] synonym: "upregulation of skeletal muscle development" EXACT [] is_a: GO:0045844 ! positive regulation of striated muscle tissue development is_a: GO:0048641 ! regulation of skeletal muscle tissue development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0007519 ! positively regulates skeletal muscle tissue development relationship: RO:0002213 GO:0007519 ! positively regulates skeletal muscle tissue development [Term] id: GO:0048644 name: muscle organ morphogenesis namespace: biological_process def: "The process in which the anatomical structures of muscle are generated and organized." [GOC:jid] is_a: GO:0009887 ! animal organ morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0001630 ! results in morphogenesis of muscle organ relationship: BFO:0000050 GO:0007517 ! part of muscle organ development relationship: RO:0002298 UBERON:0001630 ! results in morphogenesis of muscle organ [Term] id: GO:0048645 name: animal organ formation namespace: biological_process def: "The process pertaining to the initial formation of an animal organ from unspecified parts. The process begins with the specific processes that contribute to the appearance of the discrete structure, such as inductive events, and ends when the structural rudiment of the organ is recognizable, such as a condensation of mesenchymal cells into the organ rudiment. Organs are a natural part or structure in an animal or a plant, capable of performing some special action (termed its function), which is essential to the life or well-being of the whole. The heart and lungs are organs of animals, and the petal and leaf are organs of plants. In animals the organs are generally made up of several tissues, one of which usually predominates, and determines the principal function of the organ." [GOC:dph, GOC:jid] synonym: "animal organ primordium initiation" NARROW [] synonym: "initiation of an animal organ primordium" NARROW [] is_a: BFO:0000003 is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0003103 ! results in formation of anatomical entity compound organ relationship: BFO:0000050 GO:0009887 ! part of animal organ morphogenesis relationship: RO:0002297 UBERON:0003103 ! results in formation of anatomical entity compound organ [Term] id: GO:0048646 name: anatomical structure formation involved in morphogenesis namespace: biological_process def: "The developmental process pertaining to the initial formation of an anatomical structure from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome." [GOC:dph, GOC:jid, GOC:tb] comment: Note that, for example, the formation of a pseudopod in an amoeba would not be considered formation involved in morphogenesis because it would not be thought of as the formation of an anatomical structure that was part of the shaping of the amoeba during its development. The formation of an axon from a neuron would be considered the formation of an anatomical structure involved in morphogenesis because it contributes to the creation of the form of the neuron in a developmental sense. subset: goslim_chembl synonym: "formation of an anatomical structure involved in morphogenesis" EXACT [GOC:dph, GOC:tb] is_a: GO:0032502 ! developmental process relationship: BFO:0000050 GO:0009653 ! part of anatomical structure morphogenesis [Term] id: GO:0048659 name: smooth muscle cell proliferation namespace: biological_process def: "The multiplication or reproduction of smooth muscle cells, resulting in the expansion of a cell population." [CL:0000192, GOC:ebc, PMID:1840698] synonym: "SMC proliferation" EXACT [] is_a: GO:0033002 ! muscle cell proliferation intersection_of: GO:0008283 ! cell population proliferation intersection_of: RO:0012003 CL:0000192 ! acts on population of smooth muscle cell relationship: RO:0012003 CL:0000192 ! acts on population of smooth muscle cell property_value: RO:0002161 NCBITaxon:4751 [Term] id: GO:0048660 name: regulation of smooth muscle cell proliferation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of smooth muscle cell proliferation." [CL:0000192, GOC:ebc] synonym: "regulation of SMC proliferation" EXACT [] is_a: GO:0042127 ! regulation of cell population proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0048659 ! regulates smooth muscle cell proliferation relationship: RO:0002211 GO:0048659 ! regulates smooth muscle cell proliferation property_value: RO:0002161 NCBITaxon:4751 [Term] id: GO:0048661 name: positive regulation of smooth muscle cell proliferation namespace: biological_process def: "Any process that activates or increases the rate or extent of smooth muscle cell proliferation." [CL:0000192, GOC:ebc] synonym: "activation of smooth muscle cell proliferation" NARROW [] synonym: "positive regulation of SMC proliferation" EXACT [] synonym: "stimulation of smooth muscle cell proliferation" NARROW [] synonym: "up regulation of smooth muscle cell proliferation" EXACT [] synonym: "up-regulation of smooth muscle cell proliferation" EXACT [] synonym: "upregulation of smooth muscle cell proliferation" EXACT [] is_a: GO:0008284 ! positive regulation of cell population proliferation is_a: GO:0048660 ! regulation of smooth muscle cell proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0048659 ! positively regulates smooth muscle cell proliferation relationship: RO:0002213 GO:0048659 ! positively regulates smooth muscle cell proliferation property_value: RO:0002161 NCBITaxon:4751 [Term] id: GO:0048662 name: negative regulation of smooth muscle cell proliferation namespace: biological_process def: "Any process that stops, prevents or reduces the rate or extent of smooth muscle cell proliferation." [CL:0000192, GOC:ebc] synonym: "down regulation of smooth muscle cell proliferation" EXACT [] synonym: "down-regulation of smooth muscle cell proliferation" EXACT [] synonym: "downregulation of smooth muscle cell proliferation" EXACT [] synonym: "inhibition of smooth muscle cell proliferation" NARROW [] synonym: "negative regulation of SMC proliferation" EXACT [] is_a: GO:0008285 ! negative regulation of cell population proliferation is_a: GO:0048660 ! regulation of smooth muscle cell proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0048659 ! negatively regulates smooth muscle cell proliferation relationship: RO:0002212 GO:0048659 ! negatively regulates smooth muscle cell proliferation property_value: RO:0002161 NCBITaxon:4751 [Term] id: GO:0048666 name: neuron development namespace: biological_process def: "The process whose specific outcome is the progression of a neuron over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell." [GOC:dph] is_a: GO:0048468 ! cell development intersection_of: GO:0032502 ! developmental process intersection_of: RO:0002296 CL:0000540 ! results in development of neuron relationship: BFO:0000050 GO:0030182 ! part of neuron differentiation relationship: RO:0002296 CL:0000540 ! results in development of neuron [Term] id: GO:0048667 name: cell morphogenesis involved in neuron differentiation namespace: biological_process def: "The process in which the structures of a neuron are generated and organized. This process occurs while the initially relatively unspecialized cell is acquiring the specialized features of a neuron." [GOC:dph, GOC:tb] synonym: "neuron morphogenesis involved in differentiation" EXACT [GOC:dph, GOC:tb] is_a: GO:0000902 ! cell morphogenesis intersection_of: GO:0000902 ! cell morphogenesis intersection_of: BFO:0000050 GO:0030182 ! part of neuron differentiation relationship: BFO:0000050 GO:0048666 ! part of neuron development [Term] id: GO:0048699 name: generation of neurons namespace: biological_process def: "The process in which nerve cells are generated. This includes the production of neuroblasts and their differentiation into neurons." [GOC:nln] synonym: "neuron generation" EXACT [] is_a: GO:0022008 ! neurogenesis [Term] id: GO:0048705 name: skeletal system morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the skeleton are generated and organized." [GOC:dph, GOC:dsf, GOC:jid, GOC:tb] synonym: "skeletal morphogenesis" EXACT [GOC:dph, GOC:tb] is_a: GO:0009887 ! animal organ morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0001434 ! results in morphogenesis of skeletal system relationship: BFO:0000050 GO:0001501 ! part of skeletal system development relationship: RO:0002298 UBERON:0001434 ! results in morphogenesis of skeletal system [Term] id: GO:0048707 name: instar larval or pupal morphogenesis namespace: biological_process def: "The process, occurring during instar larval or pupal development, by which anatomical structures are generated and organized." [GOC:mtg_sensu, GOC:rc] is_a: GO:0009886 ! post-embryonic animal morphogenesis relationship: BFO:0000050 GO:0002165 ! part of instar larval or pupal development [Term] id: GO:0048708 name: astrocyte differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires the specialized features of an astrocyte. An astrocyte is the most abundant type of glial cell. Astrocytes provide support for neurons and regulate the environment in which they function." [GOC:vp, PMID:15139015] is_a: GO:0010001 ! glial cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000127 ! results in acquisition of features of astrocyte relationship: BFO:0000050 GO:0007417 ! part of central nervous system development relationship: RO:0002315 CL:0000127 ! results in acquisition of features of astrocyte [Term] id: GO:0048709 name: oligodendrocyte differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires the specialized features of an oligodendrocyte. An oligodendrocyte is a type of glial cell involved in myelinating the axons of neurons in the central nervous system." [GOC:vp, PMID:15139015] is_a: GO:0010001 ! glial cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000128 ! results in acquisition of features of oligodendrocyte relationship: BFO:0000050 GO:0007417 ! part of central nervous system development relationship: RO:0002315 CL:0000128 ! results in acquisition of features of oligodendrocyte [Term] id: GO:0048710 name: regulation of astrocyte differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of astrocyte differentiation." [GOC:vp, PMID:15139015] is_a: GO:0045685 ! regulation of glial cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0048708 ! regulates astrocyte differentiation relationship: RO:0002211 GO:0048708 ! regulates astrocyte differentiation [Term] id: GO:0048711 name: positive regulation of astrocyte differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of astrocyte differentiation." [GOC:vp, PMID:15139015] synonym: "activation of astrocyte differentiation" NARROW [] synonym: "stimulation of astrocyte differentiation" NARROW [] synonym: "up regulation of astrocyte differentiation" EXACT [] synonym: "up-regulation of astrocyte differentiation" EXACT [] synonym: "upregulation of astrocyte differentiation" EXACT [] is_a: GO:0045687 ! positive regulation of glial cell differentiation is_a: GO:0048710 ! regulation of astrocyte differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0048708 ! positively regulates astrocyte differentiation relationship: RO:0002213 GO:0048708 ! positively regulates astrocyte differentiation [Term] id: GO:0048712 name: negative regulation of astrocyte differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of astrocyte differentiation." [GOC:vp, PMID:15139015] synonym: "down regulation of astrocyte differentiation" EXACT [] synonym: "down-regulation of astrocyte differentiation" EXACT [] synonym: "downregulation of astrocyte differentiation" EXACT [] synonym: "inhibition of astrocyte differentiation" NARROW [] is_a: GO:0045686 ! negative regulation of glial cell differentiation is_a: GO:0048710 ! regulation of astrocyte differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0048708 ! negatively regulates astrocyte differentiation relationship: RO:0002212 GO:0048708 ! negatively regulates astrocyte differentiation [Term] id: GO:0048713 name: regulation of oligodendrocyte differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of oligodendrocyte differentiation." [GOC:vp, PMID:15139015] is_a: GO:0045685 ! regulation of glial cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0048709 ! regulates oligodendrocyte differentiation relationship: RO:0002211 GO:0048709 ! regulates oligodendrocyte differentiation [Term] id: GO:0048714 name: positive regulation of oligodendrocyte differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of oligodendrocyte differentiation." [GOC:vp, PMID:15139015] synonym: "activation of oligodendrocyte differentiation" NARROW [] synonym: "stimulation of oligodendrocyte differentiation" NARROW [] synonym: "up regulation of oligodendrocyte differentiation" EXACT [] synonym: "up-regulation of oligodendrocyte differentiation" EXACT [] synonym: "upregulation of oligodendrocyte differentiation" EXACT [] is_a: GO:0045687 ! positive regulation of glial cell differentiation is_a: GO:0048713 ! regulation of oligodendrocyte differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0048709 ! positively regulates oligodendrocyte differentiation relationship: RO:0002213 GO:0048709 ! positively regulates oligodendrocyte differentiation [Term] id: GO:0048715 name: negative regulation of oligodendrocyte differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of oligodendrocyte differentiation." [GOC:vp, PMID:15139015] synonym: "down regulation of oligodendrocyte differentiation" EXACT [] synonym: "down-regulation of oligodendrocyte differentiation" EXACT [] synonym: "downregulation of oligodendrocyte differentiation" EXACT [] synonym: "inhibition of oligodendrocyte differentiation" NARROW [] is_a: GO:0045686 ! negative regulation of glial cell differentiation is_a: GO:0048713 ! regulation of oligodendrocyte differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0048709 ! negatively regulates oligodendrocyte differentiation relationship: RO:0002212 GO:0048709 ! negatively regulates oligodendrocyte differentiation [Term] id: GO:0048729 name: tissue morphogenesis namespace: biological_process def: "The process in which the anatomical structures of a tissue are generated and organized." [GOC:dph, GOC:jid] is_a: BFO:0000003 is_a: GO:0009653 ! anatomical structure morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0000479 ! results in morphogenesis of tissue relationship: BFO:0000050 GO:0009888 ! part of tissue development relationship: RO:0002298 UBERON:0000479 ! results in morphogenesis of tissue property_value: RO:0002161 NCBITaxon:147554 property_value: RO:0002161 NCBITaxon:33630 property_value: RO:0002161 NCBITaxon:33682 property_value: RO:0002161 NCBITaxon:38254 property_value: RO:0002161 NCBITaxon:4891 [Term] id: GO:0048730 name: epidermis morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the epidermis are generated and organized. The epidermis is the outer epithelial layer of an animal, it may be a single layer that produces an extracellular material (e.g. the cuticle of arthropods) or a complex stratified squamous epithelium, as in the case of many vertebrate species." [GOC:jid, UBERON:0001003] synonym: "hypodermis morphogenesis" RELATED [GOC:kmv, GOC:rk] is_a: GO:0002009 ! morphogenesis of an epithelium intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0007376 ! results in morphogenesis of outer epithelium relationship: BFO:0000050 GO:0008544 ! part of epidermis development relationship: RO:0002298 UBERON:0007376 ! results in morphogenesis of outer epithelium [Term] id: GO:0048731 name: system development namespace: biological_process def: "The process whose specific outcome is the progression of an organismal system over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process." [GOC:dph, GOC:jid] subset: goslim_mouse is_a: GO:0048856 ! anatomical structure development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0000467 ! results in development of anatomical system relationship: BFO:0000050 GO:0007275 ! part of multicellular organism development relationship: RO:0002296 UBERON:0000467 ! results in development of anatomical system property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0048732 name: gland development namespace: biological_process def: "The process whose specific outcome is the progression of a gland over time, from its formation to the mature structure. A gland is an organ specialised for secretion." [GOC:jid] is_a: GO:0048513 ! animal organ development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0002530 ! results in development of gland relationship: RO:0002296 UBERON:0002530 ! results in development of gland [Term] id: GO:0048733 name: sebaceous gland development namespace: biological_process def: "The process whose specific outcome is the progression of the sebaceous gland over time, from its formation to the mature structure." [GOC:jid] is_a: GO:0048732 ! gland development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0001821 ! results in development of sebaceous gland relationship: BFO:0000050 GO:0043588 ! part of skin development relationship: RO:0002162 NCBITaxon:40674 ! in taxon Mammalia relationship: RO:0002296 UBERON:0001821 ! results in development of sebaceous gland [Term] id: GO:0048736 name: appendage development namespace: biological_process def: "The process whose specific outcome is the progression of an appendage over time, from its formation to the mature structure. An appendage is an organ or part that is attached to the trunk of an organism, such as a limb or a branch." [GOC:jid, GOC:rc] is_a: GO:0048856 ! anatomical structure development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0000026 ! results in development of appendage relationship: BFO:0000050 GO:0007275 ! part of multicellular organism development relationship: RO:0002296 UBERON:0000026 ! results in development of appendage [Term] id: GO:0048738 name: cardiac muscle tissue development namespace: biological_process def: "The process whose specific outcome is the progression of cardiac muscle over time, from its formation to the mature structure." [GOC:dph, GOC:jid, GOC:lm] synonym: "heart muscle development" EXACT [] is_a: GO:0014706 ! striated muscle tissue development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0001133 ! results in development of cardiac muscle tissue relationship: BFO:0000050 GO:0007507 ! part of heart development relationship: RO:0002296 UBERON:0001133 ! results in development of cardiac muscle tissue [Term] id: GO:0048741 name: skeletal muscle fiber development namespace: biological_process def: "The process whose specific outcome is the progression of the skeletal muscle fiber over time, from its formation to the mature structure. Muscle fibers are formed by the maturation of myotubes. They can be classed as slow, intermediate/fast or fast." [GOC:dph, GOC:ef, GOC:jid, GOC:lm, GOC:mtg_muscle] synonym: "skeletal muscle fibre development" EXACT [] synonym: "skeletal myofiber development" EXACT [] synonym: "skeletal myofibre development" EXACT [] is_a: GO:0014904 ! myotube cell development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 CL:0008002 ! results in development of skeletal muscle fiber relationship: BFO:0000050 GO:0007519 ! part of skeletal muscle tissue development relationship: RO:0002296 CL:0008002 ! results in development of skeletal muscle fiber [Term] id: GO:0048742 name: regulation of skeletal muscle fiber development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of skeletal muscle fiber development. Muscle fibers are formed by the maturation of myotubes. They can be classed as slow, intermediate/fast or fast." [GOC:dph, GOC:jid, GOC:mtg_muscle, GOC:sm] synonym: "regulation of skeletal muscle fibre development" EXACT [] synonym: "regulation of skeletal myofiber development" EXACT [] synonym: "regulation of skeletal myofibre development" EXACT [] is_a: GO:0010830 ! regulation of myotube differentiation is_a: GO:0060284 ! regulation of cell development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0048741 ! regulates skeletal muscle fiber development relationship: RO:0002211 GO:0048741 ! regulates skeletal muscle fiber development [Term] id: GO:0048743 name: positive regulation of skeletal muscle fiber development namespace: biological_process def: "Any process that activates, maintains or increases the rate of skeletal muscle fiber development. Muscle fibers are formed by the maturation of myotubes. They can be classed as slow, intermediate/fast or fast." [GOC:dph, GOC:jid, GOC:lm, GOC:mtg_muscle] synonym: "activation of skeletal muscle fiber development" NARROW [] synonym: "positive regulation of skeletal muscle fibre development" EXACT [] synonym: "positive regulation of skeletal myofiber development" EXACT [] synonym: "positive regulation of skeletal myofibre development" EXACT [] synonym: "stimulation of skeletal muscle fiber development" NARROW [] synonym: "up regulation of skeletal muscle fiber development" EXACT [] synonym: "up-regulation of skeletal muscle fiber development" EXACT [] synonym: "upregulation of skeletal muscle fiber development" EXACT [] is_a: GO:0010720 ! positive regulation of cell development is_a: GO:0048643 ! positive regulation of skeletal muscle tissue development is_a: GO:0048742 ! regulation of skeletal muscle fiber development is_a: GO:0051155 ! positive regulation of striated muscle cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0048741 ! positively regulates skeletal muscle fiber development relationship: RO:0002213 GO:0048741 ! positively regulates skeletal muscle fiber development [Term] id: GO:0048744 name: negative regulation of skeletal muscle fiber development namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of skeletal muscle fiber development. Muscle fibers are formed by the maturation of myotubes. They can be classed as slow, intermediate/fast or fast." [GOC:dph, GOC:jid, GOC:lm, GOC:mtg_muscle] synonym: "down regulation of skeletal muscle fiber development" EXACT [] synonym: "down-regulation of skeletal muscle fiber development" EXACT [] synonym: "downregulation of skeletal muscle fiber development" EXACT [] synonym: "inhibition of skeletal muscle fiber development" NARROW [] synonym: "negative regulation of skeletal muscle fibre development" EXACT [] synonym: "negative regulation of skeletal myofiber development" EXACT [] synonym: "negative regulation of skeletal myofibre development" EXACT [] is_a: GO:0010721 ! negative regulation of cell development is_a: GO:0048742 ! regulation of skeletal muscle fiber development is_a: GO:0051154 ! negative regulation of striated muscle cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0048741 ! negatively regulates skeletal muscle fiber development relationship: RO:0002212 GO:0048741 ! negatively regulates skeletal muscle fiber development [Term] id: GO:0048745 name: smooth muscle tissue development namespace: biological_process def: "The process whose specific outcome is the progression of smooth muscle over time, from its formation to the mature structure." [GOC:dph, GOC:jid, GOC:lm] is_a: GO:0060537 ! muscle tissue development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0001135 ! results in development of smooth muscle tissue relationship: RO:0002296 UBERON:0001135 ! results in development of smooth muscle tissue [Term] id: GO:0048749 name: compound eye development namespace: biological_process def: "The process whose specific outcome is the progression of the compound eye over time, from its formation to the mature structure. The compound eye is an organ of sight that contains multiple repeating units, often arranged hexagonally. Each unit has its own lens and photoreceptor cell(s) and can generate either a single pixelated image or multiple images, per eye." [GOC:jid, GOC:mtg_sensu, Wikipedia:Eye] synonym: "insect-type retina development" EXACT [PMID:11735386] is_a: GO:0001654 ! eye development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0000018 ! results in development of compound eye relationship: RO:0002296 UBERON:0000018 ! results in development of compound eye [Term] id: GO:0048752 name: semicircular canal morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the semicircular canals are generated and organized." [GOC:dgh, GOC:dph, GOC:jid] synonym: "embryonic semicircular canal morphogenesis" EXACT [] is_a: GO:0035239 ! tube morphogenesis is_a: GO:0048598 ! embryonic morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0001840 ! results in morphogenesis of semicircular canal relationship: BFO:0000050 GO:0042472 ! part of inner ear morphogenesis relationship: BFO:0000050 GO:0060872 ! part of semicircular canal development relationship: RO:0002298 UBERON:0001840 ! results in morphogenesis of semicircular canal [Term] id: GO:0048753 name: pigment granule organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a pigment granule." [GOC:rc] subset: goslim_pir synonym: "pigment granule organisation" EXACT [] synonym: "pigment granule organization and biogenesis" RELATED [GOC:mah] is_a: GO:0016050 ! vesicle organization intersection_of: GO:0016043 ! cellular component organization intersection_of: RO:0002592 GO:0048770 ! results in organization of pigment granule relationship: BFO:0000050 GO:0033059 ! part of cellular pigmentation relationship: RO:0002592 GO:0048770 ! results in organization of pigment granule [Term] id: GO:0048754 name: branching morphogenesis of an epithelial tube namespace: biological_process def: "The process in which the anatomical structures of branches in an epithelial tube are generated and organized. A tube is a long hollow cylinder." [GOC:dgh, GOC:dph, GOC:jid] synonym: "tubulogenesis" RELATED [GOC:dph, GOC:tb] is_a: GO:0035239 ! tube morphogenesis is_a: GO:0061138 ! morphogenesis of a branching epithelium intersection_of: GO:0001763 ! morphogenesis of a branching structure intersection_of: RO:0002298 UBERON:0000025 ! results in morphogenesis of tube relationship: BFO:0000050 GO:0060562 ! part of epithelial tube morphogenesis [Term] id: GO:0048755 name: branching morphogenesis of a nerve namespace: biological_process def: "The process in which the anatomical structures of branches in a nerve are generated and organized. This term refers to an anatomical structure (nerve) not a cell (neuron)." [GOC:dgh, GOC:dph, GOC:jid] is_a: BFO:0000003 is_a: GO:0001763 ! morphogenesis of a branching structure intersection_of: GO:0001763 ! morphogenesis of a branching structure intersection_of: RO:0002298 UBERON:0001021 ! results in morphogenesis of nerve relationship: BFO:0000050 GO:0007399 ! part of nervous system development relationship: RO:0002298 UBERON:0001021 ! results in morphogenesis of nerve [Term] id: GO:0048762 name: mesenchymal cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a mesenchymal cell. A mesenchymal cell is a loosely associated cell that is part of the connective tissue in an organism. Mesenchymal cells give rise to more mature connective tissue cell types." [GOC:dph, GOC:jid] is_a: GO:0030154 ! cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0008019 ! results in acquisition of features of mesenchymal cell relationship: BFO:0000050 GO:0060485 ! part of mesenchyme development relationship: RO:0002315 CL:0008019 ! results in acquisition of features of mesenchymal cell [Term] id: GO:0048770 name: pigment granule namespace: cellular_component def: "A small, subcellular membrane-bounded vesicle containing pigment and/or pigment precursor molecules. Pigment granule biogenesis is poorly understood, as pigment granules are derived from multiple sources including the endoplasmic reticulum, coated vesicles, lysosomes, and endosomes." [GOC:jid, GOC:mh] is_a: GO:0031410 ! cytoplasmic vesicle [Term] id: GO:0048771 name: tissue remodeling namespace: biological_process def: "The reorganization or renovation of existing tissues. This process can either change the characteristics of a tissue such as in blood vessel remodeling, or result in the dynamic equilibrium of a tissue such as in bone remodeling." [GOC:ebc] subset: goslim_pir synonym: "tissue remodelling" EXACT [] is_a: GO:0032501 ! multicellular organismal process property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0048772 name: leucophore differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires the specialized features of a leucophore cell. Leucophores are pigment cells derived from the neural crest. They contain uric acid or other purine crystals, deposited in stacks called leucosomes. This gives them a white appearance." [GOC:jid, GOC:mh] synonym: "leucophore cell differentiation" EXACT [] is_a: GO:0050931 ! pigment cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000571 ! results in acquisition of features of leucophore relationship: RO:0002162 NCBITaxon:89593 ! in taxon Craniata relationship: RO:0002315 CL:0000571 ! results in acquisition of features of leucophore [Term] id: GO:0048773 name: erythrophore differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires the specialized features of an erythrophore cell. Erythrophores are pigment cells derived from the neural crest. They contain pteridine and/or carotenoid pigments in structures called pterinosomes or erythrosomes. This gives them an orange to red appearance." [GOC:jid, GOC:mh] synonym: "erythrophore cell differentiation" EXACT [] is_a: GO:0050931 ! pigment cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000574 ! results in acquisition of features of erythrophore relationship: RO:0002162 NCBITaxon:89593 ! in taxon Craniata relationship: RO:0002315 CL:0000574 ! results in acquisition of features of erythrophore [Term] id: GO:0048774 name: cyanophore differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires the specialized features of a cyanophore cell. Cyanophores are pigment cells derived from the neural crest. They contain a blue pigment of unknown chemical composition. The pigment is stored in fibrous organelles termed cyanosomes." [GOC:jid, GOC:mh] synonym: "cyanophore cell differentiation" EXACT [] is_a: GO:0050931 ! pigment cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000747 ! results in acquisition of features of cyanophore relationship: RO:0002162 NCBITaxon:89593 ! in taxon Craniata relationship: RO:0002315 CL:0000747 ! results in acquisition of features of cyanophore [Term] id: GO:0048775 name: regulation of leucophore differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of leucophore differentiation." [GOC:mh] is_a: GO:0050932 ! regulation of pigment cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0048772 ! regulates leucophore differentiation relationship: RO:0002211 GO:0048772 ! regulates leucophore differentiation [Term] id: GO:0048776 name: negative regulation of leucophore differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of leucophore differentiation." [GOC:mh] synonym: "down regulation of leucophore differentiation" EXACT [] synonym: "down-regulation of leucophore differentiation" EXACT [] synonym: "downregulation of leucophore differentiation" EXACT [] synonym: "inhibition of leucophore differentiation" NARROW [] is_a: GO:0048775 ! regulation of leucophore differentiation is_a: GO:0050941 ! negative regulation of pigment cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0048772 ! negatively regulates leucophore differentiation relationship: RO:0002212 GO:0048772 ! negatively regulates leucophore differentiation [Term] id: GO:0048777 name: positive regulation of leucophore differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of leucophore differentiation." [GOC:mh] synonym: "activation of leucophore differentiation" NARROW [] synonym: "stimulation of leucophore differentiation" NARROW [] synonym: "up regulation of leucophore differentiation" EXACT [] synonym: "up-regulation of leucophore differentiation" EXACT [] synonym: "upregulation of leucophore differentiation" EXACT [] is_a: GO:0048775 ! regulation of leucophore differentiation is_a: GO:0050942 ! positive regulation of pigment cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0048772 ! positively regulates leucophore differentiation relationship: RO:0002213 GO:0048772 ! positively regulates leucophore differentiation [Term] id: GO:0048778 name: regulation of erythrophore differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of erythrophore differentiation." [GOC:mh] is_a: GO:0050932 ! regulation of pigment cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0048773 ! regulates erythrophore differentiation relationship: RO:0002211 GO:0048773 ! regulates erythrophore differentiation [Term] id: GO:0048779 name: negative regulation of erythrophore differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of erythrophore differentiation." [GOC:mh] synonym: "down regulation of erythrophore differentiation" EXACT [] synonym: "down-regulation of erythrophore differentiation" EXACT [] synonym: "downregulation of erythrophore differentiation" EXACT [] synonym: "inhibition of erythrophore differentiation" NARROW [] is_a: GO:0048778 ! regulation of erythrophore differentiation is_a: GO:0050941 ! negative regulation of pigment cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0048773 ! negatively regulates erythrophore differentiation relationship: RO:0002212 GO:0048773 ! negatively regulates erythrophore differentiation [Term] id: GO:0048780 name: positive regulation of erythrophore differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of erythrophore differentiation." [GOC:mh] synonym: "activation of erythrophore differentiation" NARROW [] synonym: "stimulation of erythrophore differentiation" NARROW [] synonym: "up regulation of erythrophore differentiation" EXACT [] synonym: "up-regulation of erythrophore differentiation" EXACT [] synonym: "upregulation of erythrophore differentiation" EXACT [] is_a: GO:0048778 ! regulation of erythrophore differentiation is_a: GO:0050942 ! positive regulation of pigment cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0048773 ! positively regulates erythrophore differentiation relationship: RO:0002213 GO:0048773 ! positively regulates erythrophore differentiation [Term] id: GO:0048781 name: regulation of cyanophore differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cyanophore differentiation." [GOC:mh] is_a: GO:0050932 ! regulation of pigment cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0048774 ! regulates cyanophore differentiation relationship: RO:0002211 GO:0048774 ! regulates cyanophore differentiation [Term] id: GO:0048782 name: negative regulation of cyanophore differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cyanophore differentiation." [GOC:mh] synonym: "down regulation of cyanophore differentiation" EXACT [] synonym: "down-regulation of cyanophore differentiation" EXACT [] synonym: "downregulation of cyanophore differentiation" EXACT [] synonym: "inhibition of cyanophore differentiation" NARROW [] is_a: GO:0048781 ! regulation of cyanophore differentiation is_a: GO:0050941 ! negative regulation of pigment cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0048774 ! negatively regulates cyanophore differentiation relationship: RO:0002212 GO:0048774 ! negatively regulates cyanophore differentiation [Term] id: GO:0048783 name: positive regulation of cyanophore differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cyanophore differentiation." [GOC:mh] synonym: "activation of cyanophore differentiation" NARROW [] synonym: "stimulation of cyanophore differentiation" NARROW [] synonym: "up regulation of cyanophore differentiation" EXACT [] synonym: "up-regulation of cyanophore differentiation" EXACT [] synonym: "upregulation of cyanophore differentiation" EXACT [] is_a: GO:0048781 ! regulation of cyanophore differentiation is_a: GO:0050942 ! positive regulation of pigment cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0048774 ! positively regulates cyanophore differentiation relationship: RO:0002213 GO:0048774 ! positively regulates cyanophore differentiation [Term] id: GO:0048791 name: calcium ion-regulated exocytosis of neurotransmitter namespace: biological_process def: "The release of a neurotransmitter into the synaptic cleft by exocytosis of synaptic vesicles, where the release step is dependent on a rise in cytosolic calcium ion levels." [GOC:curators] is_a: GO:0016079 ! synaptic vesicle exocytosis is_a: GO:0017156 ! calcium-ion regulated exocytosis intersection_of: GO:0016079 ! synaptic vesicle exocytosis intersection_of: RO:0002334 GO:0007204 ! regulated by positive regulation of cytosolic calcium ion concentration [Term] id: GO:0048793 name: pronephros development namespace: biological_process def: "The process whose specific outcome is the progression of the pronephros over time, from its formation to the mature structure. In mammals, the pronephros is the first of the three embryonic kidneys to be established and exists only transiently. In lower vertebrates such as fish and amphibia, the pronephros is the fully functional embryonic kidney and is indispensable for larval life." [GOC:bf, GOC:mtg_kidney_jan10, PMID:10535314, PMID:15968585, PMID:18322540, XAO:00002000, ZFA:0000151] synonym: "pronephric kidney development" EXACT [GOC:mtg_kidney_jan10] is_a: GO:0001822 ! kidney development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0002120 ! results in development of pronephros relationship: RO:0002296 UBERON:0002120 ! results in development of pronephros [Term] id: GO:0048799 name: animal organ maturation namespace: biological_process def: "A developmental process, independent of morphogenetic (shape) change, that is required for an animal organ to attain its fully functional state. An organ is a tissue or set of tissues that work together to perform a specific function or functions." [GOC:curators] is_a: GO:0071695 ! anatomical structure maturation intersection_of: GO:0021700 ! developmental maturation intersection_of: RO:0002299 UBERON:0000062 ! results in maturation of organ relationship: BFO:0000050 GO:0048513 ! part of animal organ development relationship: RO:0002299 UBERON:0000062 ! results in maturation of organ [Term] id: GO:0048806 name: genitalia development namespace: biological_process def: "The process whose specific outcome is the progression of the genitalia over time, from its formation to the mature structure." [GOC:jid] synonym: "genital development" EXACT [] is_a: GO:0048513 ! animal organ development is_a: GO:0048608 ! reproductive structure development relationship: BFO:0000050 GO:0007548 ! part of sex differentiation property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0048808 name: male genitalia morphogenesis namespace: biological_process def: "The process in which the anatomical structures of male genitalia are generated and organized." [GOC:ems, ISBN:0140512888] synonym: "male genital morphogenesis" RELATED [] is_a: GO:0035112 ! genitalia morphogenesis is_a: GO:0090598 ! male anatomical structure morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0000079 ! results in morphogenesis of male reproductive system relationship: BFO:0000050 GO:0030539 ! part of male genitalia development relationship: RO:0002298 UBERON:0000079 ! results in morphogenesis of male reproductive system [Term] id: GO:0048812 name: neuron projection morphogenesis namespace: biological_process def: "The process in which the anatomical structures of a neuron projection are generated and organized. A neuron projection is any process extending from a neural cell, such as axons or dendrites." [GOC:mah] synonym: "neurite biosynthesis" NARROW [] synonym: "neurite formation" NARROW [] synonym: "neurite growth" NARROW [] synonym: "neurite morphogenesis" RELATED [GOC:dph, GOC:tb] is_a: GO:0120039 ! plasma membrane bounded cell projection morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 GO:0043005 ! results in morphogenesis of neuron projection relationship: BFO:0000050 GO:0031175 ! part of neuron projection development relationship: RO:0002298 GO:0043005 ! results in morphogenesis of neuron projection [Term] id: GO:0048813 name: dendrite morphogenesis namespace: biological_process def: "The process in which the anatomical structures of a dendrite are generated and organized." [GOC:aruk, GOC:bc, GOC:jl, ISBN:0198506732, PMID:22683681] is_a: GO:0048812 ! neuron projection morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 GO:0030425 ! results in morphogenesis of dendrite relationship: BFO:0000050 GO:0016358 ! part of dendrite development relationship: BFO:0000050 GO:0048667 ! part of cell morphogenesis involved in neuron differentiation relationship: RO:0002298 GO:0030425 ! results in morphogenesis of dendrite [Term] id: GO:0048814 name: regulation of dendrite morphogenesis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of dendrite morphogenesis." [GOC:ai] is_a: GO:0022603 ! regulation of anatomical structure morphogenesis is_a: GO:0050773 ! regulation of dendrite development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0048813 ! regulates dendrite morphogenesis relationship: RO:0002211 GO:0048813 ! regulates dendrite morphogenesis [Term] id: GO:0048817 name: negative regulation of hair follicle maturation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of hair follicle maturation." [GOC:devbiol] synonym: "down regulation of hair follicle maturation" EXACT [] synonym: "down-regulation of hair follicle maturation" EXACT [] synonym: "downregulation of hair follicle maturation" EXACT [] synonym: "inhibition of hair follicle maturation" NARROW [] is_a: GO:0048819 ! regulation of hair follicle maturation is_a: GO:0051799 ! negative regulation of hair follicle development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0048820 ! negatively regulates hair follicle maturation relationship: RO:0002212 GO:0048820 ! negatively regulates hair follicle maturation [Term] id: GO:0048818 name: positive regulation of hair follicle maturation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of hair follicle maturation." [GOC:devbiol] synonym: "activation of hair follicle maturation" NARROW [] synonym: "stimulation of hair follicle maturation" NARROW [] synonym: "up regulation of hair follicle maturation" EXACT [] synonym: "up-regulation of hair follicle maturation" EXACT [] synonym: "upregulation of hair follicle maturation" EXACT [] is_a: GO:0048819 ! regulation of hair follicle maturation is_a: GO:0051798 ! positive regulation of hair follicle development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0048820 ! positively regulates hair follicle maturation relationship: RO:0002213 GO:0048820 ! positively regulates hair follicle maturation [Term] id: GO:0048819 name: regulation of hair follicle maturation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of hair follicle maturation." [GOC:devbiol] is_a: GO:0050793 ! regulation of developmental process is_a: GO:0051239 ! regulation of multicellular organismal process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0048820 ! regulates hair follicle maturation relationship: RO:0002211 GO:0048820 ! regulates hair follicle maturation [Term] id: GO:0048820 name: hair follicle maturation namespace: biological_process def: "A developmental process, independent of morphogenetic (shape) change, that is required for a hair follicle to attain its fully functional state." [GOC:devbiol] is_a: GO:0022405 ! hair cycle process is_a: GO:0071695 ! anatomical structure maturation intersection_of: GO:0021700 ! developmental maturation intersection_of: RO:0002299 UBERON:0002073 ! results in maturation of hair follicle relationship: BFO:0000050 GO:0001942 ! part of hair follicle development relationship: RO:0002299 UBERON:0002073 ! results in maturation of hair follicle [Term] id: GO:0048821 name: erythrocyte development namespace: biological_process def: "The process whose specific outcome is the progression of an erythrocyte over time, from its formation to the mature structure." [GOC:devbiol] synonym: "RBC development" EXACT [CL:0000232] synonym: "red blood cell development" EXACT [CL:0000232] is_a: GO:0061515 ! myeloid cell development intersection_of: GO:0032502 ! developmental process intersection_of: RO:0002296 CL:0000232 ! results in development of erythrocyte relationship: BFO:0000050 GO:0030218 ! part of erythrocyte differentiation relationship: RO:0002296 CL:0000232 ! results in development of erythrocyte [Term] id: GO:0048822 name: enucleate erythrocyte development namespace: biological_process def: "The process aimed at the progression of an enucleate erythrocyte over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell." [GOC:devbiol] synonym: "enucleate RBC development" EXACT [CL:0000232] synonym: "enucleate red blood cell development" EXACT [CL:0000232] is_a: GO:0048821 ! erythrocyte development intersection_of: GO:0032502 ! developmental process intersection_of: RO:0002296 CL:0000595 ! results in development of enucleate erythrocyte relationship: BFO:0000050 GO:0043353 ! part of enucleate erythrocyte differentiation relationship: RO:0002296 CL:0000595 ! results in development of enucleate erythrocyte [Term] id: GO:0048823 name: nucleate erythrocyte development namespace: biological_process def: "The process aimed at the progression of a nucleate erythrocyte over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell." [GOC:devbiol] synonym: "nucleate RBC development" EXACT [CL:0000232] synonym: "nucleate red blood cell development" EXACT [CL:0000232] is_a: GO:0048821 ! erythrocyte development intersection_of: GO:0032502 ! developmental process intersection_of: RO:0002296 CL:0000562 ! results in development of nucleate erythrocyte relationship: BFO:0000050 GO:0043363 ! part of nucleate erythrocyte differentiation relationship: RO:0002296 CL:0000562 ! results in development of nucleate erythrocyte [Term] id: GO:0048839 name: inner ear development namespace: biological_process def: "The process whose specific outcome is the progression of the inner ear over time, from its formation to the mature structure." [GOC:sr] is_a: GO:0048856 ! anatomical structure development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0001846 ! results in development of internal ear relationship: BFO:0000050 GO:0043583 ! part of ear development relationship: RO:0002296 UBERON:0001846 ! results in development of internal ear [Term] id: GO:0048844 name: artery morphogenesis namespace: biological_process def: "The process in which the anatomical structures of arterial blood vessels are generated and organized. Arteries are blood vessels that transport blood from the heart to the body and its organs." [GOC:dsf, PMID:16740480] synonym: "arterial morphogenesis" EXACT [] synonym: "arteriogenesis" EXACT [GOC:mtg_heart] is_a: GO:0048514 ! blood vessel morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0001637 ! results in morphogenesis of artery relationship: BFO:0000050 GO:0060840 ! part of artery development relationship: RO:0002298 UBERON:0001637 ! results in morphogenesis of artery [Term] id: GO:0048845 name: venous blood vessel morphogenesis namespace: biological_process def: "The process in which the anatomical structures of venous blood vessels are generated and organized. Veins are blood vessels that transport blood from the body and its organs to the heart." [GOC:dsf, PMID:16740480] synonym: "vein morphogenesis" BROAD [] synonym: "venous morphogenesis" EXACT [] is_a: GO:0048514 ! blood vessel morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0001638 ! results in morphogenesis of vein relationship: BFO:0000050 GO:0060841 ! part of venous blood vessel development relationship: RO:0002298 UBERON:0001638 ! results in morphogenesis of vein [Term] id: GO:0048847 name: adenohypophysis formation namespace: biological_process def: "The process that gives rise to adenohypophysis. This process pertains to the initial formation of a structure from unspecified parts. The adenohypophysis is the anterior part of the pituitary. It secretes a variety of hormones and its function is regulated by the hypothalamus." [GOC:cvs, GOC:dgh, GOC:dph, GOC:jid] synonym: "adenophysis biosynthesis" EXACT [] synonym: "adenophysis formation" EXACT [] synonym: "anterior pituitary biosynthesis" EXACT [] synonym: "anterior pituitary formation" EXACT [] synonym: "anterior pituitary gland biosynthesis" EXACT [] synonym: "anterior pituitary gland formation" EXACT [] is_a: BFO:0000003 is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0002196 ! results in formation of anatomical entity adenohypophysis relationship: BFO:0000050 GO:0048855 ! part of adenohypophysis morphogenesis relationship: RO:0002297 UBERON:0002196 ! results in formation of anatomical entity adenohypophysis [Term] id: GO:0048848 name: neurohypophysis morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the neurohypophysis are generated and organized. The neurohypophysis is the part of the pituitary gland that secretes hormones involved in blood pressure regulation." [GOC:cls, GOC:dgh, GOC:dph, GOC:jid] synonym: "neurophysis morphogenesis" EXACT [] synonym: "posterior pituitary gland morphogenesis" EXACT [] synonym: "posterior pituitary morphogenesis" EXACT [] is_a: GO:0022612 ! gland morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0002198 ! results in morphogenesis of neurohypophysis relationship: BFO:0000050 GO:0021985 ! part of neurohypophysis development relationship: BFO:0000050 GO:0048850 ! part of hypophysis morphogenesis relationship: RO:0002298 UBERON:0002198 ! results in morphogenesis of neurohypophysis [Term] id: GO:0048849 name: neurohypophysis formation namespace: biological_process def: "The process that gives rise to neurohypophysis. This process pertains to the initial formation of a structure from unspecified parts. The neurohypophysis is the part of the pituitary gland that secretes hormones involved in blood pressure regulation." [GOC:cls, GOC:dgh, GOC:dph, GOC:jid] synonym: "neurophysis biosynthesis" EXACT [] synonym: "neurophysis formation" EXACT [] synonym: "posterior pituitary biosynthesis" EXACT [] synonym: "posterior pituitary formation" EXACT [] synonym: "posterior pituitary gland biosynthesis" EXACT [] synonym: "posterior pituitary gland formation" EXACT [] is_a: BFO:0000003 is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0002198 ! results in formation of anatomical entity neurohypophysis relationship: BFO:0000050 GO:0048848 ! part of neurohypophysis morphogenesis relationship: RO:0002297 UBERON:0002198 ! results in formation of anatomical entity neurohypophysis [Term] id: GO:0048850 name: hypophysis morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the hypophysis are generated and organized. The pituitary gland is an endocrine gland that secretes hormones that regulate many other glands." [GOC:cls, GOC:dgh, GOC:dph, GOC:jid] synonym: "pituitary gland morphogenesis" EXACT [] is_a: GO:0022612 ! gland morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0000007 ! results in morphogenesis of pituitary gland relationship: BFO:0000050 GO:0021983 ! part of pituitary gland development relationship: BFO:0000050 GO:0048852 ! part of diencephalon morphogenesis relationship: RO:0002298 UBERON:0000007 ! results in morphogenesis of pituitary gland [Term] id: GO:0048851 name: hypophysis formation namespace: biological_process def: "The process in which the anatomical structures of the hypophysis are generated and organized. The hypophysis is an endocrine gland that secretes hormones that regulate many other glands." [GOC:cls, GOC:dgh, GOC:dph, GOC:jid] synonym: "hypophysis biosynthesis" EXACT [] synonym: "pituitary gland biosynthesis" EXACT [] synonym: "pituitary gland formation" EXACT [] is_a: BFO:0000003 is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0000007 ! results in formation of anatomical entity pituitary gland relationship: BFO:0000050 GO:0048850 ! part of hypophysis morphogenesis relationship: RO:0002297 UBERON:0000007 ! results in formation of anatomical entity pituitary gland [Term] id: GO:0048852 name: diencephalon morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the diencephalon are generated and organized. The diencephalon is the paired caudal parts of the prosencephalon from which the thalamus, hypothalamus, epithalamus and subthalamus are derived; these regions regulate autonomic, visceral and endocrine function, and process information directed to the cerebral cortex." [GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] is_a: BFO:0000003 is_a: GO:0009653 ! anatomical structure morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0001894 ! results in morphogenesis of diencephalon relationship: BFO:0000050 GO:0021536 ! part of diencephalon development relationship: BFO:0000050 GO:0048853 ! part of forebrain morphogenesis relationship: RO:0002298 UBERON:0001894 ! results in morphogenesis of diencephalon [Term] id: GO:0048853 name: forebrain morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the forebrain are generated and organized. The forebrain is the anterior of the three primary divisions of the developing chordate brain or the corresponding part of the adult brain (in vertebrates, includes especially the cerebral hemispheres, the thalamus, and the hypothalamus and especially in higher vertebrates is the main control center for sensory and associative information processing, visceral functions, and voluntary motor functions)." [GOC:cvs, GOC:dgh, GOC:dph, GOC:jid] synonym: "prosencephalon morphogenesis" EXACT [] is_a: BFO:0000003 is_a: GO:0009653 ! anatomical structure morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0001890 ! results in morphogenesis of forebrain relationship: BFO:0000050 GO:0030900 ! part of forebrain development relationship: BFO:0000050 GO:0048854 ! part of brain morphogenesis relationship: RO:0002298 UBERON:0001890 ! results in morphogenesis of forebrain [Term] id: GO:0048854 name: brain morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the brain are generated and organized. The brain is one of the two components of the central nervous system and is the center of thought and emotion. It is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)." [GOC:dgh, GOC:jid] is_a: GO:0009887 ! animal organ morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0000955 ! results in morphogenesis of brain relationship: BFO:0000050 GO:0007420 ! part of brain development relationship: RO:0002298 UBERON:0000955 ! results in morphogenesis of brain [Term] id: GO:0048855 name: adenohypophysis morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the adenohypophysis are generated and organized. The adenohypophysis is the anterior part of the pituitary. It secretes a variety of hormones and its function is regulated by the hypothalamus." [GOC:cvs, GOC:dgh, GOC:dph, GOC:jid] synonym: "adenophysis morphogenesis" EXACT [] synonym: "anterior pituitary gland morphogenesis" EXACT [] synonym: "anterior pituitary morphogenesis" EXACT [] is_a: BFO:0000003 is_a: GO:0009653 ! anatomical structure morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0002196 ! results in morphogenesis of adenohypophysis relationship: BFO:0000050 GO:0021984 ! part of adenohypophysis development relationship: BFO:0000050 GO:0048850 ! part of hypophysis morphogenesis relationship: RO:0002298 UBERON:0002196 ! results in morphogenesis of adenohypophysis [Term] id: GO:0048856 name: anatomical structure development namespace: biological_process def: "The biological process whose specific outcome is the progression of an anatomical structure from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure, whatever form that may be including its natural destruction. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome." [GO_REF:0000021] subset: gocheck_do_not_annotate subset: goslim_chembl subset: goslim_generic subset: goslim_plant subset: goslim_plant_ribbon synonym: "development of an anatomical structure" EXACT [] is_a: BFO:0000003 is_a: GO:0032502 ! developmental process intersection_of: GO:0032502 ! developmental process intersection_of: RO:0002296 UBERON:0000061 ! results in development of anatomical structure relationship: RO:0002296 UBERON:0000061 ! results in development of anatomical structure property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/26424" xsd:anyURI [Term] id: GO:0048857 name: neural nucleus development namespace: biological_process def: "The biological process whose specific outcome is the progression of a neural nucleus from its initial condition to its mature state. A neural nucleus is an anatomical structure consisting of a discrete aggregate of neuronal soma." [GO_REF:0000021] is_a: GO:0048856 ! anatomical structure development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0000125 ! results in development of neural nucleus relationship: RO:0002296 UBERON:0000125 ! results in development of neural nucleus [Term] id: GO:0048858 name: cell projection morphogenesis namespace: biological_process def: "The process in which the anatomical structures of a cell projection are generated and organized." [GO_REF:0000021] is_a: GO:0009653 ! anatomical structure morphogenesis is_a: GO:0030030 ! cell projection organization intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 GO:0042995 ! results in morphogenesis of cell projection relationship: BFO:0000050 GO:0000902 ! part of cell morphogenesis relationship: RO:0002298 GO:0042995 ! results in morphogenesis of cell projection [Term] id: GO:0048859 name: formation of anatomical boundary namespace: biological_process def: "The process in which the limits of an anatomical structure are generated. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome." [GO_REF:0000021] is_a: BFO:0000003 is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0007651 ! results in formation of anatomical entity anatomical junction relationship: RO:0002297 UBERON:0007651 ! results in formation of anatomical entity anatomical junction [Term] id: GO:0048860 name: glioblast division namespace: biological_process def: "The process resulting in the physical partitioning and separation of a glioblast into daughter cells." [GOC:devbiol] is_a: BFO:0000003 is_a: GO:0051301 ! cell division intersection_of: GO:0051301 ! cell division intersection_of: RO:0004009 CL:0000030 ! has primary input glioblast relationship: RO:0004009 CL:0000030 ! has primary input glioblast [Term] id: GO:0048863 name: stem cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a stem cell. A stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells." [CL:0000034, GOC:isa_complete] xref: Wikipedia:Stem_cell_differentiation is_a: GO:0030154 ! cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000034 ! results in acquisition of features of stem cell relationship: RO:0002315 CL:0000034 ! results in acquisition of features of stem cell [Term] id: GO:0048864 name: stem cell development namespace: biological_process def: "The process whose specific outcome is the progression of the stem cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to its specific fate." [CL:0000034, GOC:isa_complete] is_a: GO:0048468 ! cell development intersection_of: GO:0032502 ! developmental process intersection_of: RO:0002296 CL:0000034 ! results in development of stem cell relationship: BFO:0000050 GO:0048863 ! part of stem cell differentiation relationship: RO:0002296 CL:0000034 ! results in development of stem cell [Term] id: GO:0048869 name: cellular developmental process namespace: biological_process def: "A biological process whose specific outcome is the progression of a cell over time from an initial condition to a later condition." [GOC:isa_complete] is_a: GO:0009987 ! cellular process is_a: GO:0032502 ! developmental process [Term] id: GO:0048870 name: cell motility namespace: biological_process def: "Any process involved in the controlled self-propelled movement of a cell that results in translocation of the cell from one place to another." [GOC:dgh, GOC:dph, GOC:isa_complete, GOC:mlg] subset: goslim_chembl subset: goslim_drosophila subset: goslim_euk_cellular_processes_ribbon subset: goslim_generic subset: goslim_prokaryote synonym: "cell locomotion" EXACT [] synonym: "cell movement" RELATED [] synonym: "movement of a cell" EXACT [] is_a: GO:0009987 ! cellular process property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/19809" xsd:anyURI property_value: RO:0002161 NCBITaxon:4890 [Term] id: GO:0048871 name: multicellular organismal-level homeostasis namespace: biological_process def: "Any process involved in the maintenance of an internal steady state at the level of the multicellular organism." [GOC:isa_complete] is_a: GO:0032501 ! multicellular organismal process is_a: GO:0042592 ! homeostatic process property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0048872 name: homeostasis of number of cells namespace: biological_process def: "Any biological process involved in the maintenance of the steady-state number of cells within a population of cells." [GOC:isa_complete] synonym: "cell population homeostasis" EXACT [] synonym: "homeostasis of cell number" EXACT [GOC:dph] is_a: GO:0048871 ! multicellular organismal-level homeostasis property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/24218" xsd:anyURI property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0048873 name: homeostasis of number of cells within a tissue namespace: biological_process def: "Any biological process involved in the maintenance of the steady-state number of cells within a population of cells in a tissue." [GOC:isa_complete] is_a: GO:0001894 ! tissue homeostasis is_a: GO:0048872 ! homeostasis of number of cells property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0048878 name: chemical homeostasis namespace: biological_process def: "Any biological process involved in the maintenance of an internal steady state of a chemical." [GOC:isa_complete] subset: goslim_drosophila is_a: GO:0042592 ! homeostatic process intersection_of: GO:0042592 ! homeostatic process intersection_of: RO:0002332 CHEBI:24431 ! regulates levels of relationship: RO:0002332 CHEBI:24431 ! regulates levels of [Term] id: GO:0048880 name: sensory system development namespace: biological_process def: "The process whose specific outcome is the progression of a sensory system over time from its formation to the mature structure." [GOC:dgh] is_a: GO:0048731 ! system development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0001032 ! results in development of sensory system relationship: RO:0002162 NCBITaxon:6072 ! in taxon Eumetazoa relationship: RO:0002296 UBERON:0001032 ! results in development of sensory system [Term] id: GO:0048881 name: mechanosensory lateral line system development namespace: biological_process def: "The process whose specific outcome is the progression of the mechanosensory lateral line system over time, from its formation to the mature structure. The mechanosensory lateral line system consists of small sensory patches (neuromasts) located superficially on the skin or just under the skin in fluid-filled canals on the head and body of all fishes and most amphibians. The neuromasts are innervated by several lateral line nerves, which project primarily to the hindbrain. The mechanosensory lateral line system is stimulated by local water displacements and vibrations, and detects propulsion of the fish through the water, as well as facilitating shoaling, prey capture, and predator and obstacle avoidance." [ISBN:0125296509] synonym: "LL system development" EXACT [ISBN:0125296509] is_a: GO:0048925 ! lateral line system development [Term] id: GO:0048882 name: lateral line development namespace: biological_process def: "The process whose specific outcome is the progression of the lateral line over time, from its formation to the mature structure. The lateral line consists of small sensory patches (neuromasts) located superficially on the skin or just under the skin in fluid-filled canals on the head and body of all fishes and most amphibians. The lateral line develops from cranial ectodermal placodes situated behind the ear and between the eye and ear." [ISBN:0125296509] synonym: "LL development" EXACT [] is_a: GO:0009888 ! tissue development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0010202 ! results in development of lateral line relationship: BFO:0000050 GO:0048925 ! part of lateral line system development relationship: RO:0002296 UBERON:0010202 ! results in development of lateral line [Term] id: GO:0048884 name: neuromast development namespace: biological_process def: "The process whose specific outcome is the progression of the neuromast over time, from its formation to the mature structure. The neuromast is the sensory organ of the lateral line and is composed of a population of sensory hair cells, and nonsensory supporting cells and mantle cells. Neuromasts are located superficially on the epithelium or in lateral line canals." [ISBN:0125296509] is_a: GO:0007423 ! sensory organ development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0008904 ! results in development of neuromast relationship: BFO:0000050 GO:0048882 ! part of lateral line development relationship: RO:0002296 UBERON:0008904 ! results in development of neuromast [Term] id: GO:0048886 name: neuromast hair cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a neuromast hair cell. Hair cells are the sensory receptors of the neuromast and are located in a portion of the neuromast called the sensory strip. Each hair cell of the neuromast is morphologically polarized as a result of the relative position of the single kinocilium and the clusters of stereocilia on its apical surface. There are approximately seven hair cells within each neuromast, with each hair cell innervated by afferent and efferent neurons." [CL:0000856, ISBN:0125296509] is_a: GO:0035315 ! hair cell differentiation is_a: GO:0042490 ! mechanoreceptor differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000856 ! results in acquisition of features of neuromast hair cell relationship: BFO:0000050 GO:0048884 ! part of neuromast development relationship: RO:0002315 CL:0000856 ! results in acquisition of features of neuromast hair cell [Term] id: GO:0048888 name: neuromast mantle cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a neuromast mantle cell. Mantle cells are non-sensory cells that surround the sensory strip, separating the neuromast from the epidermis. Mantle cells secrete the cupula in which the ciliary bundles of all of the hair cells are embedded." [ISBN:0125296509] is_a: GO:0030154 ! cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000851 ! results in acquisition of features of neuromast mantle cell relationship: BFO:0000050 GO:0048884 ! part of neuromast development relationship: RO:0002315 CL:0000851 ! results in acquisition of features of neuromast mantle cell [Term] id: GO:0048889 name: neuromast support cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a neuromast support cell. Support cells are non-sensory cells of the neuromast that extend between the sensory hair cells from the basement membrane to the apical surface; they are surrounded by mantle cells." [ISBN:0125296509] is_a: GO:0030154 ! cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000852 ! results in acquisition of features of neuromast supporting cell relationship: BFO:0000050 GO:0048884 ! part of neuromast development relationship: RO:0002315 CL:0000852 ! results in acquisition of features of neuromast supporting cell [Term] id: GO:0048890 name: lateral line ganglion development namespace: biological_process def: "The process whose specific outcome is the progression of the lateral line ganglion over time, from its formation to the mature structure. The lateral line ganglion develops from cranial ectodermal placodes situated between the eye and ear and behind the ear." [ISBN:0125296509, ISBN:0387968377] synonym: "gLL ganglion development" EXACT [] is_a: GO:0061550 ! cranial ganglion development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:2000120 ! results in development of lateral line ganglion relationship: BFO:0000050 GO:0007422 ! part of peripheral nervous system development relationship: BFO:0000050 GO:0048925 ! part of lateral line system development relationship: RO:0002296 UBERON:2000120 ! results in development of lateral line ganglion [Term] id: GO:0048891 name: lateral line ganglion neuron differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a lateral line ganglion neuron." [PMID:15018940] synonym: "gLL neuron differentiation" EXACT [] is_a: GO:0048934 ! peripheral nervous system neuron differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:2000031 ! results in acquisition of features of lateral line ganglion neuron relationship: BFO:0000050 GO:0048890 ! part of lateral line ganglion development relationship: RO:0002315 CL:2000031 ! results in acquisition of features of lateral line ganglion neuron [Term] id: GO:0048892 name: lateral line nerve development namespace: biological_process def: "The process whose specific outcome is the progression of the lateral line nerve over time, form its formation to the mature structure. Lateral line nerves project primarily to an octavolateralis column in the hindbrain that consists of the medial octavolateralis nucleus (MON), the caudal octavolateralis nucleus, and the magnocellular nucleus." [ISBN:0125296509] synonym: "nLL development" EXACT [] is_a: GO:0021545 ! cranial nerve development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0008906 ! results in development of lateral line nerve relationship: BFO:0000050 GO:0048925 ! part of lateral line system development relationship: RO:0002296 UBERON:0008906 ! results in development of lateral line nerve [Term] id: GO:0048895 name: lateral line nerve glial cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a glial cell in a lateral line nerve." [PMID:12062041] is_a: GO:0010001 ! glial cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:1000050 ! results in acquisition of features of lateral line nerve glial cell relationship: BFO:0000050 GO:0048892 ! part of lateral line nerve development relationship: RO:0002315 CL:1000050 ! results in acquisition of features of lateral line nerve glial cell [Term] id: GO:0048896 name: lateral line nerve glial cell migration namespace: biological_process def: "The movement of a glial cell along the axons in a lateral line nerve." [PMID:12062041] synonym: "glial cell migration in lateral line nerve" EXACT [] is_a: GO:0008347 ! glial cell migration intersection_of: GO:0016477 ! cell migration intersection_of: RO:0002565 CL:1000050 ! results in movement of lateral line nerve glial cell relationship: BFO:0000050 GO:0048892 ! part of lateral line nerve development relationship: RO:0002565 CL:1000050 ! results in movement of lateral line nerve glial cell [Term] id: GO:0048898 name: anterior lateral line system development namespace: biological_process def: "The process whose specific outcome is the progression of the anterior lateral line system over time, from its formation to the mature structure. The anterior lateral line system develops from cranial ectodermal placodes, situated between the eye and the ear, that give rise to both the neuromasts and the anterior lateral line sensory nerves that innervate the neuromasts. The anterior lateral line system consists of small sensory patches (neuromasts) located superficially on the skin or just under the skin in fluid-filled canals on the head of all fishes and most amphibians and are innervated by several lateral line nerves, which project to the hindbrain. The anterior lateral line system is stimulated by local water displacements and vibrations, and detects propulsion of the fish through the water, as well as facilitating shoaling, prey capture, and predator and obstacle avoidance." [ISBN:0125296509, PMID:15018940] synonym: "ALL system development" RELATED [] is_a: GO:0048925 ! lateral line system development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:2001468 ! results in development of anterior lateral line system relationship: BFO:0000050 GO:0048881 ! part of mechanosensory lateral line system development relationship: RO:0002296 UBERON:2001468 ! results in development of anterior lateral line system [Term] id: GO:0048899 name: anterior lateral line development namespace: biological_process def: "The process whose specific outcome is the progression of the anterior lateral line over time, from its formation to the mature structure. The anterior lateral line consists of small sensory patches (neuromasts) located superficially on the skin or just under the skin in fluid-filled canals on the head of all fishes and most amphibians. The anterior lateral line develops from cranial ectodermal placodes situated between the eye and ear." [ISBN:0125296509] synonym: "anterior LL development" EXACT [] is_a: GO:0048882 ! lateral line development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:2001470 ! results in development of anterior lateral line relationship: BFO:0000050 GO:0048898 ! part of anterior lateral line system development relationship: RO:0002296 UBERON:2001470 ! results in development of anterior lateral line [Term] id: GO:0048901 name: anterior lateral line neuromast development namespace: biological_process def: "The process whose specific outcome is the progression of the anterior lateral line neuromast over time, from its formation to the mature structure. The neuromast is the sensory receptor of the anterior lateral line system and is composed of a population of sensory hair cells, and nonsensory supporting cells and mantle cells. Neuromast are located superficially on the epithelium or in lateral line canals." [ISBN:0125296509] is_a: GO:0048884 ! neuromast development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:2001472 ! results in development of anterior lateral line neuromast relationship: BFO:0000050 GO:0048899 ! part of anterior lateral line development relationship: RO:0002296 UBERON:2001472 ! results in development of anterior lateral line neuromast [Term] id: GO:0048903 name: anterior lateral line neuromast hair cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of an anterior lateral line neuromast hair cell. Neuromast hair cells are the sensory receptors of the neuromast and are located in a portion of the neuromast called the sensory strip. Each hair cell of the neuromast is morphologically polarized as a result of the relative position of the single kinocilium and the clusters of stereocilia on its apical surface. There are approximately seven hair cells within each neuromast, with each hair cell innervated by afferent and efferent neurons." [ISBN:0125296509, ISBN:0387968377] is_a: GO:0048886 ! neuromast hair cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:2000034 ! results in acquisition of features of anterior lateral line neuromast hair cell relationship: BFO:0000050 GO:0048901 ! part of anterior lateral line neuromast development relationship: RO:0002315 CL:2000034 ! results in acquisition of features of anterior lateral line neuromast hair cell [Term] id: GO:0048905 name: anterior lateral line neuromast mantle cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of an anterior lateral line neuromast mantle cell. Mantle cells are non-sensory cells that surround the sensory strip, separating the neuromast from the epidermis. Mantle cells secrete the cupula in which the ciliary bundles of all of the hair cells are embedded." [ISBN:0125296509] is_a: GO:0048888 ! neuromast mantle cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:2000035 ! results in acquisition of features of anterior lateral line neuromast mantle cell relationship: BFO:0000050 GO:0048901 ! part of anterior lateral line neuromast development relationship: RO:0002315 CL:2000035 ! results in acquisition of features of anterior lateral line neuromast mantle cell [Term] id: GO:0048906 name: anterior lateral line neuromast support cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of an anterior lateral line neuromast support cell. Support cells are non-sensory cells of the neuromast that extend between the sensory hair cells from the basement membrane to the apical surface; they are surrounded by mantle cells." [ISBN:0387968377] is_a: GO:0048889 ! neuromast support cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:2000036 ! results in acquisition of features of anterior lateral line neuromast supporting cell relationship: BFO:0000050 GO:0048901 ! part of anterior lateral line neuromast development relationship: RO:0002315 CL:2000036 ! results in acquisition of features of anterior lateral line neuromast supporting cell [Term] id: GO:0048907 name: anterior lateral line ganglion development namespace: biological_process def: "The process whose specific outcome is the progression of the anterior lateral line ganglion over time, from its formation to the mature structure. The anterior lateral line ganglion develops from cranial ectodermal placodes situated between the eye and ear." [ISBN:0125296509] synonym: "gALL development" EXACT [] is_a: GO:0048890 ! lateral line ganglion development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:2001391 ! results in development of anterior lateral line ganglion relationship: BFO:0000050 GO:0048898 ! part of anterior lateral line system development relationship: RO:0002296 UBERON:2001391 ! results in development of anterior lateral line ganglion [Term] id: GO:0048909 name: anterior lateral line nerve development namespace: biological_process def: "The process whose specific outcome is the progression of the anterior lateral line nerve over time, form its formation to the mature structure. The anterior lateral line nerve contains efferent axons that innervate hair cells of the ALL and afferent axons that project to an octavolateralis column in the hindbrain. The octavolateralis column consists of the medial octavolateralis nucleus (MON), the caudal octavolateralis nucleus, and the magnocellular nucleus." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0125296509] synonym: "ALLN development" EXACT [] synonym: "nALL development" EXACT [] synonym: "rostral lateral line nerve development" EXACT [] is_a: GO:0048892 ! lateral line nerve development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:2000425 ! results in development of anterior lateral line nerve relationship: BFO:0000050 GO:0048898 ! part of anterior lateral line system development relationship: RO:0002296 UBERON:2000425 ! results in development of anterior lateral line nerve [Term] id: GO:0048913 name: anterior lateral line nerve glial cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a glial cell in the anterior lateral line nerve." [PMID:15832385] is_a: GO:0048895 ! lateral line nerve glial cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:1000239 ! results in acquisition of features of anterior lateral line nerve glial cell relationship: BFO:0000050 GO:0048909 ! part of anterior lateral line nerve development relationship: RO:0002315 CL:1000239 ! results in acquisition of features of anterior lateral line nerve glial cell [Term] id: GO:0048915 name: posterior lateral line system development namespace: biological_process def: "The process whose specific outcome is the progression of the posterior lateral line system over time, from its formation to the mature structure. The posterior lateral line system develops from cranial ectodermal placodes, situated behind the ear, that give rise to both the neuromasts and the posterior lateral line sensory nerves that innervate the neuromasts. The posterior lateral line system consists of small sensory patches (neuromasts) located superficially on the skin or just under the skin in fluid-filled canals on the head of all fishes and most amphibians. The neuromasts are innervated by several lateral line nerves, which project primarily to the hindbrain. The posterior mechanosensory lateral line system is stimulated by local water displacements and vibrations, and detects propulsion of the fish through the water, as well as facilitating shoaling, prey capture, and predator and obstacle avoidance." [ISBN:0125296509, PMID:15018940] synonym: "PLL" RELATED [] is_a: GO:0048925 ! lateral line system development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:2001471 ! results in development of posterior lateral line system relationship: BFO:0000050 GO:0048881 ! part of mechanosensory lateral line system development relationship: RO:0002296 UBERON:2001471 ! results in development of posterior lateral line system [Term] id: GO:0048916 name: posterior lateral line development namespace: biological_process def: "The process whose specific outcome is the progression of the posterior lateral line over time, from its formation to the mature structure. The posterior lateral line consists of small sensory patches (neuromasts) located superficially on the skin or just under the skin in fluid-filled canals on the body and trunk of all fishes and most amphibians. The posterior lateral line develops from cranial ectodermal placodes situated behind the ear." [ISBN:0125296509] synonym: "PLL development" EXACT [] is_a: GO:0048882 ! lateral line development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0006334 ! results in development of posterior lateral line relationship: BFO:0000050 GO:0048915 ! part of posterior lateral line system development relationship: RO:0002296 UBERON:0006334 ! results in development of posterior lateral line [Term] id: GO:0048917 name: posterior lateral line ganglion development namespace: biological_process def: "The process whose specific outcome is the progression of the posterior lateral line ganglion over time, from its formation to the mature structure. The posterior lateral line ganglion develops from cranial ectodermal placodes situated behind the ear." [ISBN:0125296509, ISBN:0387968377] synonym: "gPLL development" EXACT [] is_a: GO:0048890 ! lateral line ganglion development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:2001314 ! results in development of posterior lateral line ganglion relationship: BFO:0000050 GO:0048915 ! part of posterior lateral line system development relationship: RO:0002296 UBERON:2001314 ! results in development of posterior lateral line ganglion [Term] id: GO:0048918 name: posterior lateral line nerve development namespace: biological_process def: "The process whose specific outcome is the progression of the posterior lateral line nerve over time, from its formation to the mature structure. The posterior lateral line nerve innervates hair cells of the PLL and projects to an octavolateralis column in the hindbrain that consists of the medial octavolateralis nucleus (MON), the caudal octavolateralis nucleus, and the magnocellular nucleus." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0125296509] synonym: "caudal lateral line nerve development" EXACT [] synonym: "PLLN development" EXACT [] is_a: GO:0048892 ! lateral line nerve development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:2000175 ! results in development of posterior lateral line nerve relationship: BFO:0000050 GO:0048915 ! part of posterior lateral line system development relationship: RO:0002296 UBERON:2000175 ! results in development of posterior lateral line nerve [Term] id: GO:0048919 name: posterior lateral line neuromast development namespace: biological_process def: "The process whose specific outcome is the progression of the posterior lateral line neuromast over time, from its formation to the mature structure. The neuromast is the sensory receptor of the anterior lateral line system and is composed of a population of sensory hair cells, and nonsensory supporting cells and mantle cells. Neuromast are located superficially on the epithelium or in lateral line canals." [ISBN:0125296509] is_a: GO:0048884 ! neuromast development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:2000940 ! results in development of posterior lateral line neuromast relationship: BFO:0000050 GO:0048916 ! part of posterior lateral line development relationship: RO:0002296 UBERON:2000940 ! results in development of posterior lateral line neuromast [Term] id: GO:0048923 name: posterior lateral line neuromast hair cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a posterior lateral line neuromast hair cell. (N.B. This may be development of neuromast hair cell type or a set of cell of neuromast hair cell type. This will involve the change of a cell or set of cells from one cell identity to another). Hair cells are the sensory receptors of the neuromast and are located in a portion of the neuromast called the sensory strip. Each hair cell of the neuromast is morphologically polarized as a result of the relative position of the single kinocilium and the clusters of stereocilia on its apical surface. There are approximately seven hair cells within each neuromast, with each hair cell innervated by afferent and efferent neurons." [ISBN:0125296509] is_a: GO:0048886 ! neuromast hair cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:2000037 ! results in acquisition of features of posterior lateral line neuromast hair cell relationship: BFO:0000050 GO:0048919 ! part of posterior lateral line neuromast development relationship: RO:0002315 CL:2000037 ! results in acquisition of features of posterior lateral line neuromast hair cell [Term] id: GO:0048924 name: posterior lateral line neuromast mantle cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a posterior lateral line neuromast mantle cell. (N.B. This may be development of neuromast mantle cell type or a set of cells of neuromast mantle cell type. This will involve the change of a cell or set of cells from one cell identity to another). Mantle cells are non-sensory cells that surround the sensory strip, separating the neuromast from the epidermis. Mantle cells secrete the cupula in which the ciliary bundles of all of the hair cells are embedded." [ISBN:0125296509] is_a: GO:0048888 ! neuromast mantle cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:2000038 ! results in acquisition of features of posterior lateral line neuromast mantle cell relationship: BFO:0000050 GO:0048919 ! part of posterior lateral line neuromast development relationship: RO:0002315 CL:2000038 ! results in acquisition of features of posterior lateral line neuromast mantle cell [Term] id: GO:0048925 name: lateral line system development namespace: biological_process def: "The process whose specific outcome is the progression of the lateral line system over time, from its formation to the mature structure. The lateral line system is a network of sensory organs (neuromasts) and lateral line nerves located superficially on the skin or just under the skin in fluid-filled canals on the head and body of all fishes and most amphibians. The lateral line system develops from cranial ectodermal placodes situated between the eye and ear." [GOC:dgh, ISBN:0125296509] is_a: GO:0048880 ! sensory system development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0002540 ! results in development of lateral line system relationship: RO:0002162 NCBITaxon:7742 ! in taxon Vertebrata relationship: RO:0002296 UBERON:0002540 ! results in development of lateral line system [Term] id: GO:0048927 name: posterior lateral line neuromast support cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a posterior lateral line neuromast support cell. Support cells are non-sensory cells of the neuromast that extend between the sensory hair cells from the basement membrane to the apical surface; they are surrounded by mantle cells." [ISBN:0387968377] is_a: GO:0048889 ! neuromast support cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:2000039 ! results in acquisition of features of posterior lateral line neuromast supporting cell relationship: BFO:0000050 GO:0048919 ! part of posterior lateral line neuromast development relationship: RO:0002315 CL:2000039 ! results in acquisition of features of posterior lateral line neuromast supporting cell [Term] id: GO:0048928 name: posterior lateral line ganglion neuron differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a neuron of the posterior lateral line ganglion." [PMID:15018940] is_a: GO:0048891 ! lateral line ganglion neuron differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:1000245 ! results in acquisition of features of posterior lateral line ganglion neuron relationship: BFO:0000050 GO:0048917 ! part of posterior lateral line ganglion development relationship: RO:0002315 CL:1000245 ! results in acquisition of features of posterior lateral line ganglion neuron [Term] id: GO:0048931 name: posterior lateral line nerve glial cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a glial cell in the posterior lateral line nerve." [PMID:15832385] is_a: GO:0048895 ! lateral line nerve glial cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:1000236 ! results in acquisition of features of posterior lateral line nerve glial cell relationship: BFO:0000050 GO:0048918 ! part of posterior lateral line nerve development relationship: RO:0002315 CL:1000236 ! results in acquisition of features of posterior lateral line nerve glial cell [Term] id: GO:0048934 name: peripheral nervous system neuron differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a neuron whose cell body resides in the peripheral nervous system." [GOC:dgh] is_a: GO:0030182 ! neuron differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:2000032 ! results in acquisition of features of peripheral nervous system neuron relationship: BFO:0000050 GO:0007422 ! part of peripheral nervous system development relationship: RO:0002315 CL:2000032 ! results in acquisition of features of peripheral nervous system neuron [Term] id: GO:0048935 name: peripheral nervous system neuron development namespace: biological_process def: "The process whose specific outcome is the progression of a neuron whose cell body is located in the peripheral nervous system, from initial commitment of the cell to a neuronal fate, to the fully functional differentiated neuron." [GOC:dgh] is_a: GO:0048666 ! neuron development intersection_of: GO:0048468 ! cell development intersection_of: RO:0002296 CL:2000032 ! results in development of peripheral nervous system neuron relationship: BFO:0000050 GO:0048934 ! part of peripheral nervous system neuron differentiation relationship: RO:0002296 CL:2000032 ! results in development of peripheral nervous system neuron [Term] id: GO:0048937 name: lateral line nerve glial cell development namespace: biological_process def: "The process aimed at the progression of a lateral line glial cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell." [GOC:dgh] is_a: GO:0021782 ! glial cell development intersection_of: GO:0048468 ! cell development intersection_of: RO:0002296 CL:1000050 ! results in development of lateral line nerve glial cell relationship: BFO:0000050 GO:0048895 ! part of lateral line nerve glial cell differentiation relationship: RO:0002296 CL:1000050 ! results in development of lateral line nerve glial cell [Term] id: GO:0048938 name: lateral line nerve glial cell morphogenesis involved in differentiation namespace: biological_process def: "The process in which the structure of a glial cell in a lateral line nerve is generated and organized. This process occurs while the initially relatively unspecialized cell is acquiring the specialized features of a glial cell in a lateral line nerve." [GOC:dgh] is_a: GO:0000902 ! cell morphogenesis intersection_of: GO:0000902 ! cell morphogenesis intersection_of: BFO:0000050 GO:0048937 ! part of lateral line nerve glial cell development relationship: BFO:0000050 GO:0048937 ! part of lateral line nerve glial cell development relationship: RO:0002298 CL:1000050 ! results in morphogenesis of lateral line nerve glial cell [Term] id: GO:0048939 name: anterior lateral line nerve glial cell development namespace: biological_process def: "The process aimed at the progression of a glial cell in the anterior lateral line nerve over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell." [GOC:dgh] is_a: GO:0048937 ! lateral line nerve glial cell development intersection_of: GO:0048468 ! cell development intersection_of: RO:0002296 CL:1000239 ! results in development of anterior lateral line nerve glial cell relationship: BFO:0000050 GO:0048913 ! part of anterior lateral line nerve glial cell differentiation relationship: RO:0002296 CL:1000239 ! results in development of anterior lateral line nerve glial cell [Term] id: GO:0048940 name: anterior lateral line nerve glial cell morphogenesis involved in differentiation namespace: biological_process def: "The process in which the structures of a glial cell in the anterior lateral line nerve are generated and organized. This process occurs while the initially relatively unspecialized cell is acquiring the specialized features of a glial cell in the anterior lateral line nerve." [GOC:dgh] is_a: GO:0048938 ! lateral line nerve glial cell morphogenesis involved in differentiation intersection_of: GO:0000902 ! cell morphogenesis intersection_of: BFO:0000050 GO:0048939 ! part of anterior lateral line nerve glial cell development relationship: BFO:0000050 GO:0048939 ! part of anterior lateral line nerve glial cell development [Term] id: GO:0048941 name: posterior lateral line nerve glial cell development namespace: biological_process def: "The process aimed at the progression of a glial cell in the posterior lateral line nerve over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell." [GOC:dgh] is_a: GO:0048937 ! lateral line nerve glial cell development intersection_of: GO:0048468 ! cell development intersection_of: RO:0002296 CL:1000236 ! results in development of posterior lateral line nerve glial cell relationship: BFO:0000050 GO:0048931 ! part of posterior lateral line nerve glial cell differentiation relationship: RO:0002296 CL:1000236 ! results in development of posterior lateral line nerve glial cell [Term] id: GO:0048942 name: posterior lateral line nerve glial cell morphogenesis involved in differentiation namespace: biological_process def: "The process in which the structures of a glial cell in the posterior lateral line nerve are generated and organized. This process occurs while the initially relatively unspecialized cell is acquiring the specialized features of a glial cell in the posterior lateral line nerve." [GOC:dgh] is_a: GO:0048938 ! lateral line nerve glial cell morphogenesis involved in differentiation intersection_of: GO:0000902 ! cell morphogenesis intersection_of: BFO:0000050 GO:0048941 ! part of posterior lateral line nerve glial cell development relationship: BFO:0000050 GO:0048941 ! part of posterior lateral line nerve glial cell development [Term] id: GO:0050000 name: chromosome localization namespace: biological_process def: "Any process in which a chromosome is transported to, or maintained in, a specific location." [GOC:ai] synonym: "chromosome localisation" EXACT [GOC:mah] synonym: "establishment and maintenance of chromosome localization" EXACT [] synonym: "establishment and maintenance of chromosome position" EXACT [] is_a: GO:0051640 ! organelle localization intersection_of: GO:0051179 ! localization intersection_of: RO:0004009 GO:0005694 ! has primary input chromosome relationship: RO:0004009 GO:0005694 ! has primary input chromosome [Term] id: GO:0050432 name: catecholamine secretion namespace: biological_process def: "The regulated release of catecholamines by a cell. The catecholamines are a group of physiologically important biogenic amines that possess a catechol (3,4-dihydroxyphenyl) nucleus and are derivatives of 3,4-dihydroxyphenylethylamine." [GOC:ai, GOC:ef] is_a: GO:0032940 ! secretion by cell is_a: GO:0051937 ! catecholamine transport intersection_of: GO:0046903 ! secretion intersection_of: RO:0004009 CHEBI:33567 ! has primary input [Term] id: GO:0050433 name: regulation of catecholamine secretion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the regulated release of catecholamines." [GOC:ai] is_a: GO:0051952 ! regulation of amine transport is_a: GO:1903530 ! regulation of secretion by cell intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0050432 ! regulates catecholamine secretion relationship: RO:0002211 GO:0050432 ! regulates catecholamine secretion [Term] id: GO:0050657 name: nucleic acid transport namespace: biological_process def: "The directed movement of nucleic acids, single or double-stranded polynucleotides involved in the storage, transmission and transfer of genetic information, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai, ISBN:0198506732] is_a: GO:0015931 ! nucleobase-containing compound transport intersection_of: GO:0006810 ! transport intersection_of: RO:0004009 CHEBI:33696 ! has primary input relationship: RO:0004009 CHEBI:33696 ! has primary input [Term] id: GO:0050658 name: RNA transport namespace: biological_process def: "The directed movement of RNA, ribonucleic acids, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] is_a: GO:0050657 ! nucleic acid transport is_a: GO:0051236 ! establishment of RNA localization intersection_of: GO:0006810 ! transport intersection_of: RO:0004009 CHEBI:33697 ! has primary input relationship: RO:0004009 CHEBI:33697 ! has primary input [Term] id: GO:0050670 name: regulation of lymphocyte proliferation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of lymphocyte proliferation." [GOC:ai] is_a: GO:0032944 ! regulation of mononuclear cell proliferation is_a: GO:0051249 ! regulation of lymphocyte activation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0046651 ! regulates lymphocyte proliferation relationship: RO:0002211 GO:0046651 ! regulates lymphocyte proliferation [Term] id: GO:0050671 name: positive regulation of lymphocyte proliferation namespace: biological_process def: "Any process that activates or increases the rate or extent of lymphocyte proliferation." [GOC:ai] synonym: "activation of lymphocyte proliferation" NARROW [] synonym: "stimulation of lymphocyte proliferation" NARROW [] synonym: "up regulation of lymphocyte proliferation" EXACT [] synonym: "up-regulation of lymphocyte proliferation" EXACT [] synonym: "upregulation of lymphocyte proliferation" EXACT [] is_a: GO:0032946 ! positive regulation of mononuclear cell proliferation is_a: GO:0050670 ! regulation of lymphocyte proliferation is_a: GO:0051251 ! positive regulation of lymphocyte activation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0046651 ! positively regulates lymphocyte proliferation relationship: RO:0002213 GO:0046651 ! positively regulates lymphocyte proliferation [Term] id: GO:0050672 name: negative regulation of lymphocyte proliferation namespace: biological_process def: "Any process that stops, prevents or reduces the rate or extent of lymphocyte proliferation." [GOC:ai] synonym: "down regulation of lymphocyte proliferation" EXACT [] synonym: "down-regulation of lymphocyte proliferation" EXACT [] synonym: "downregulation of lymphocyte proliferation" EXACT [] synonym: "inhibition of lymphocyte proliferation" NARROW [] is_a: GO:0032945 ! negative regulation of mononuclear cell proliferation is_a: GO:0050670 ! regulation of lymphocyte proliferation is_a: GO:0051250 ! negative regulation of lymphocyte activation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0046651 ! negatively regulates lymphocyte proliferation relationship: RO:0002212 GO:0046651 ! negatively regulates lymphocyte proliferation [Term] id: GO:0050673 name: epithelial cell proliferation namespace: biological_process def: "The multiplication or reproduction of epithelial cells, resulting in the expansion of a cell population. Epithelial cells make up the epithelium, the covering of internal and external surfaces of the body, including the lining of vessels and other small cavities. It consists of cells joined by small amounts of cementing substances." [ISBN:0721662544] is_a: BFO:0000003 is_a: GO:0008283 ! cell population proliferation intersection_of: GO:0008283 ! cell population proliferation intersection_of: RO:0012003 CL:0000066 ! acts on population of epithelial cell relationship: RO:0012003 CL:0000066 ! acts on population of epithelial cell property_value: RO:0002161 NCBITaxon:4751 [Term] id: GO:0050674 name: urothelial cell proliferation namespace: biological_process def: "The multiplication or reproduction of urothelial cells, resulting in the expansion of a cell population. Urothelial cells make up a layer of transitional epithelium in the wall of the bladder, ureter, and renal pelvis, external to the lamina propria." [ISBN:0721662544] is_a: GO:0050673 ! epithelial cell proliferation intersection_of: GO:0008283 ! cell population proliferation intersection_of: RO:0012003 CL:0000731 ! acts on population of urothelial cell relationship: RO:0012003 CL:0000731 ! acts on population of urothelial cell property_value: RO:0002161 NCBITaxon:4751 [Term] id: GO:0050675 name: regulation of urothelial cell proliferation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of urothelial cell proliferation." [GOC:ai] is_a: GO:0050678 ! regulation of epithelial cell proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0050674 ! regulates urothelial cell proliferation relationship: RO:0002211 GO:0050674 ! regulates urothelial cell proliferation property_value: RO:0002161 NCBITaxon:4751 [Term] id: GO:0050676 name: negative regulation of urothelial cell proliferation namespace: biological_process def: "Any process that stops, prevents or reduces the rate or extent of urothelial cell proliferation." [GOC:ai] synonym: "down regulation of urothelial cell proliferation" EXACT [] synonym: "down-regulation of urothelial cell proliferation" EXACT [] synonym: "downregulation of urothelial cell proliferation" EXACT [] synonym: "inhibition of urothelial cell proliferation" NARROW [] is_a: GO:0050675 ! regulation of urothelial cell proliferation is_a: GO:0050680 ! negative regulation of epithelial cell proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0050674 ! negatively regulates urothelial cell proliferation relationship: RO:0002212 GO:0050674 ! negatively regulates urothelial cell proliferation property_value: RO:0002161 NCBITaxon:4751 [Term] id: GO:0050677 name: positive regulation of urothelial cell proliferation namespace: biological_process def: "Any process that activates or increases the rate or extent of urothelial cell proliferation." [GOC:ai] synonym: "activation of urothelial cell proliferation" NARROW [] synonym: "stimulation of urothelial cell proliferation" NARROW [] synonym: "up regulation of urothelial cell proliferation" EXACT [] synonym: "up-regulation of urothelial cell proliferation" EXACT [] synonym: "upregulation of urothelial cell proliferation" EXACT [] is_a: GO:0050675 ! regulation of urothelial cell proliferation is_a: GO:0050679 ! positive regulation of epithelial cell proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0050674 ! positively regulates urothelial cell proliferation relationship: RO:0002213 GO:0050674 ! positively regulates urothelial cell proliferation property_value: RO:0002161 NCBITaxon:4751 [Term] id: GO:0050678 name: regulation of epithelial cell proliferation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of epithelial cell proliferation." [GOC:ai] is_a: GO:0042127 ! regulation of cell population proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0050673 ! regulates epithelial cell proliferation relationship: RO:0002211 GO:0050673 ! regulates epithelial cell proliferation property_value: RO:0002161 NCBITaxon:4751 [Term] id: GO:0050679 name: positive regulation of epithelial cell proliferation namespace: biological_process def: "Any process that activates or increases the rate or extent of epithelial cell proliferation." [GOC:ai] synonym: "activation of epithelial cell proliferation" NARROW [] synonym: "stimulation of epithelial cell proliferation" NARROW [] synonym: "up regulation of epithelial cell proliferation" EXACT [] synonym: "up-regulation of epithelial cell proliferation" EXACT [] synonym: "upregulation of epithelial cell proliferation" EXACT [] is_a: GO:0008284 ! positive regulation of cell population proliferation is_a: GO:0050678 ! regulation of epithelial cell proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0050673 ! positively regulates epithelial cell proliferation relationship: RO:0002213 GO:0050673 ! positively regulates epithelial cell proliferation property_value: RO:0002161 NCBITaxon:4751 [Term] id: GO:0050680 name: negative regulation of epithelial cell proliferation namespace: biological_process def: "Any process that stops, prevents or reduces the rate or extent of epithelial cell proliferation." [GOC:ai] synonym: "down regulation of epithelial cell proliferation" EXACT [] synonym: "down-regulation of epithelial cell proliferation" EXACT [] synonym: "downregulation of epithelial cell proliferation" EXACT [] synonym: "inhibition of epithelial cell proliferation" NARROW [] is_a: GO:0008285 ! negative regulation of cell population proliferation is_a: GO:0050678 ! regulation of epithelial cell proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0050673 ! negatively regulates epithelial cell proliferation relationship: RO:0002212 GO:0050673 ! negatively regulates epithelial cell proliferation property_value: RO:0002161 NCBITaxon:4751 [Term] id: GO:0050708 name: regulation of protein secretion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the controlled release of a protein from a cell." [GOC:ai] is_a: GO:0051223 ! regulation of protein transport is_a: GO:1903530 ! regulation of secretion by cell intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0009306 ! regulates protein secretion relationship: RO:0002211 GO:0009306 ! regulates protein secretion [Term] id: GO:0050709 name: negative regulation of protein secretion namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the controlled release of a protein from a cell." [GOC:ai] synonym: "down regulation of protein secretion" EXACT [] synonym: "down-regulation of protein secretion" EXACT [] synonym: "downregulation of protein secretion" EXACT [] synonym: "inhibition of protein secretion" NARROW [] is_a: GO:0050708 ! regulation of protein secretion is_a: GO:0051224 ! negative regulation of protein transport is_a: GO:1903531 ! negative regulation of secretion by cell intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0009306 ! negatively regulates protein secretion relationship: RO:0002212 GO:0009306 ! negatively regulates protein secretion [Term] id: GO:0050714 name: positive regulation of protein secretion namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the controlled release of a protein from a cell." [GOC:ai] synonym: "activation of protein secretion" NARROW [] synonym: "stimulation of protein secretion" NARROW [] synonym: "up regulation of protein secretion" EXACT [] synonym: "up-regulation of protein secretion" EXACT [] synonym: "upregulation of protein secretion" EXACT [] is_a: GO:0050708 ! regulation of protein secretion is_a: GO:0051222 ! positive regulation of protein transport is_a: GO:1903532 ! positive regulation of secretion by cell intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0009306 ! positively regulates protein secretion relationship: RO:0002213 GO:0009306 ! positively regulates protein secretion [Term] id: GO:0050727 name: regulation of inflammatory response namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the inflammatory response, the immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents." [GOC:ai] is_a: GO:0031347 ! regulation of defense response is_a: GO:0032101 ! regulation of response to external stimulus intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0006954 ! regulates inflammatory response relationship: RO:0002211 GO:0006954 ! regulates inflammatory response [Term] id: GO:0050728 name: negative regulation of inflammatory response namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the inflammatory response." [GOC:ai] synonym: "anti-inflammatory response" EXACT [] synonym: "down regulation of inflammatory response" EXACT [] synonym: "down-regulation of inflammatory response" EXACT [] synonym: "downregulation of inflammatory response" EXACT [] synonym: "inhibition of inflammatory response" NARROW [] xref: Reactome:R-HSA-9018678 "Biosynthesis of specialized proresolving mediators (SPMs)" is_a: GO:0031348 ! negative regulation of defense response is_a: GO:0032102 ! negative regulation of response to external stimulus is_a: GO:0050727 ! regulation of inflammatory response intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0006954 ! negatively regulates inflammatory response relationship: RO:0002212 GO:0006954 ! negatively regulates inflammatory response [Term] id: GO:0050729 name: positive regulation of inflammatory response namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the inflammatory response." [GOC:ai] synonym: "activation of inflammatory response" NARROW [] synonym: "stimulation of inflammatory response" NARROW [] synonym: "up regulation of inflammatory response" EXACT [] synonym: "up-regulation of inflammatory response" EXACT [] synonym: "upregulation of inflammatory response" EXACT [] is_a: GO:0031349 ! positive regulation of defense response is_a: GO:0032103 ! positive regulation of response to external stimulus is_a: GO:0050727 ! regulation of inflammatory response intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0006954 ! positively regulates inflammatory response relationship: RO:0002213 GO:0006954 ! positively regulates inflammatory response [Term] id: GO:0050730 name: regulation of peptidyl-tyrosine phosphorylation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the phosphorylation of peptidyl-tyrosine." [GOC:ai] subset: gocheck_obsoletion_candidate is_a: GO:0001932 ! regulation of protein phosphorylation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0018108 ! regulates peptidyl-tyrosine phosphorylation relationship: RO:0002211 GO:0018108 ! regulates peptidyl-tyrosine phosphorylation property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/28278" xsd:anyURI [Term] id: GO:0050731 name: positive regulation of peptidyl-tyrosine phosphorylation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the phosphorylation of peptidyl-tyrosine." [GOC:ai] subset: gocheck_obsoletion_candidate synonym: "activation of peptidyl-tyrosine phosphorylation" NARROW [] synonym: "stimulation of peptidyl-tyrosine phosphorylation" NARROW [] synonym: "up regulation of peptidyl-tyrosine phosphorylation" EXACT [] synonym: "up-regulation of peptidyl-tyrosine phosphorylation" EXACT [] synonym: "upregulation of peptidyl-tyrosine phosphorylation" EXACT [] is_a: GO:0001934 ! positive regulation of protein phosphorylation is_a: GO:0050730 ! regulation of peptidyl-tyrosine phosphorylation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0018108 ! positively regulates peptidyl-tyrosine phosphorylation relationship: RO:0002213 GO:0018108 ! positively regulates peptidyl-tyrosine phosphorylation [Term] id: GO:0050732 name: negative regulation of peptidyl-tyrosine phosphorylation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the phosphorylation of peptidyl-tyrosine." [GOC:ai] subset: gocheck_obsoletion_candidate synonym: "down regulation of peptidyl-tyrosine phosphorylation" EXACT [] synonym: "down-regulation of peptidyl-tyrosine phosphorylation" EXACT [] synonym: "downregulation of peptidyl-tyrosine phosphorylation" EXACT [] synonym: "inhibition of peptidyl-tyrosine phosphorylation" NARROW [] is_a: GO:0001933 ! negative regulation of protein phosphorylation is_a: GO:0050730 ! regulation of peptidyl-tyrosine phosphorylation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0018108 ! negatively regulates peptidyl-tyrosine phosphorylation relationship: RO:0002212 GO:0018108 ! negatively regulates peptidyl-tyrosine phosphorylation property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/28278" xsd:anyURI [Term] id: GO:0050746 name: regulation of lipoprotein metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving lipoproteins, any conjugated, water-soluble protein in which the nonprotein group consists of a lipid or lipids." [GOC:ai] synonym: "regulation of lipoprotein metabolism" EXACT [] is_a: GO:0051246 ! regulation of protein metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0042157 ! regulates lipoprotein metabolic process relationship: RO:0002211 GO:0042157 ! regulates lipoprotein metabolic process [Term] id: GO:0050747 name: positive regulation of lipoprotein metabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving lipoproteins, any conjugated, water-soluble protein in which the nonprotein group consists of a lipid or lipids." [GOC:ai] synonym: "activation of lipoprotein metabolic process" NARROW [] synonym: "positive regulation of lipoprotein metabolism" EXACT [] synonym: "stimulation of lipoprotein metabolic process" NARROW [] synonym: "up regulation of lipoprotein metabolic process" EXACT [] synonym: "up-regulation of lipoprotein metabolic process" EXACT [] synonym: "upregulation of lipoprotein metabolic process" EXACT [] is_a: GO:0009891 ! positive regulation of biosynthetic process is_a: GO:0050746 ! regulation of lipoprotein metabolic process is_a: GO:0051247 ! positive regulation of protein metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0042157 ! positively regulates lipoprotein metabolic process relationship: RO:0002213 GO:0042157 ! positively regulates lipoprotein metabolic process [Term] id: GO:0050748 name: negative regulation of lipoprotein metabolic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving lipoproteins, any conjugated, water-soluble protein in which the nonprotein group consists of a lipid or lipids." [GOC:ai] synonym: "down regulation of lipoprotein metabolic process" EXACT [] synonym: "down-regulation of lipoprotein metabolic process" EXACT [] synonym: "downregulation of lipoprotein metabolic process" EXACT [] synonym: "inhibition of lipoprotein metabolic process" NARROW [] synonym: "negative regulation of lipoprotein metabolism" EXACT [] is_a: GO:0050746 ! regulation of lipoprotein metabolic process is_a: GO:0051248 ! negative regulation of protein metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0042157 ! negatively regulates lipoprotein metabolic process relationship: RO:0002212 GO:0042157 ! negatively regulates lipoprotein metabolic process [Term] id: GO:0050764 name: regulation of phagocytosis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of phagocytosis, the process in which phagocytes engulf external particulate material." [GOC:ai] is_a: GO:0030100 ! regulation of endocytosis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0006909 ! regulates phagocytosis relationship: RO:0002211 GO:0006909 ! regulates phagocytosis property_value: RO:0002161 NCBITaxon:4751 [Term] id: GO:0050765 name: negative regulation of phagocytosis namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of phagocytosis." [GOC:ai] synonym: "down regulation of phagocytosis" EXACT [] synonym: "down-regulation of phagocytosis" EXACT [] synonym: "downregulation of phagocytosis" EXACT [] synonym: "inhibition of phagocytosis" NARROW [] is_a: GO:0045806 ! negative regulation of endocytosis is_a: GO:0050764 ! regulation of phagocytosis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0006909 ! negatively regulates phagocytosis relationship: RO:0002212 GO:0006909 ! negatively regulates phagocytosis property_value: RO:0002161 NCBITaxon:4751 [Term] id: GO:0050766 name: positive regulation of phagocytosis namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of phagocytosis." [GOC:ai] synonym: "activation of phagocytosis" NARROW [] synonym: "stimulation of phagocytosis" NARROW [] synonym: "up regulation of phagocytosis" EXACT [] synonym: "up-regulation of phagocytosis" EXACT [] synonym: "upregulation of phagocytosis" EXACT [] is_a: GO:0045807 ! positive regulation of endocytosis is_a: GO:0050764 ! regulation of phagocytosis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0006909 ! positively regulates phagocytosis relationship: RO:0002213 GO:0006909 ! positively regulates phagocytosis property_value: RO:0002161 NCBITaxon:4751 [Term] id: GO:0050767 name: regulation of neurogenesis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of neurogenesis, the generation of cells in the nervous system." [GOC:ai] is_a: GO:0051960 ! regulation of nervous system development is_a: GO:0060284 ! regulation of cell development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0022008 ! regulates neurogenesis relationship: RO:0002211 GO:0022008 ! regulates neurogenesis [Term] id: GO:0050768 name: negative regulation of neurogenesis namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of neurogenesis, the generation of cells within the nervous system." [GOC:ai] synonym: "down regulation of neurogenesis" EXACT [] synonym: "down-regulation of neurogenesis" EXACT [] synonym: "downregulation of neurogenesis" EXACT [] synonym: "inhibition of neurogenesis" NARROW [] is_a: GO:0010721 ! negative regulation of cell development is_a: GO:0050767 ! regulation of neurogenesis is_a: GO:0051961 ! negative regulation of nervous system development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0022008 ! negatively regulates neurogenesis relationship: RO:0002212 GO:0022008 ! negatively regulates neurogenesis [Term] id: GO:0050769 name: positive regulation of neurogenesis namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of neurogenesis, the generation of cells within the nervous system." [GOC:ai] synonym: "activation of neurogenesis" NARROW [] synonym: "stimulation of neurogenesis" NARROW [] synonym: "up regulation of neurogenesis" EXACT [] synonym: "up-regulation of neurogenesis" EXACT [] synonym: "upregulation of neurogenesis" EXACT [] is_a: GO:0010720 ! positive regulation of cell development is_a: GO:0050767 ! regulation of neurogenesis is_a: GO:0051962 ! positive regulation of nervous system development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0022008 ! positively regulates neurogenesis relationship: RO:0002213 GO:0022008 ! positively regulates neurogenesis [Term] id: GO:0050770 name: regulation of axonogenesis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of axonogenesis, the generation of an axon, the long process of a neuron." [GOC:ai] xref: Reactome:R-HSA-193697 "p75NTR regulates axonogenesis" is_a: GO:0010975 ! regulation of neuron projection development is_a: GO:0022603 ! regulation of anatomical structure morphogenesis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0007409 ! regulates axonogenesis relationship: RO:0002211 GO:0007409 ! regulates axonogenesis [Term] id: GO:0050771 name: negative regulation of axonogenesis namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of axonogenesis." [GOC:ai] synonym: "down regulation of axonogenesis" EXACT [] synonym: "down-regulation of axonogenesis" EXACT [] synonym: "downregulation of axonogenesis" EXACT [] synonym: "inhibition of axonogenesis" NARROW [] xref: Reactome:R-HSA-193634 "Axonal growth inhibition (RHOA activation)" is_a: GO:0010977 ! negative regulation of neuron projection development is_a: GO:0050768 ! negative regulation of neurogenesis is_a: GO:0050770 ! regulation of axonogenesis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0007409 ! negatively regulates axonogenesis relationship: RO:0002212 GO:0007409 ! negatively regulates axonogenesis [Term] id: GO:0050772 name: positive regulation of axonogenesis namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of axonogenesis." [GOC:ai] synonym: "activation of axonogenesis" NARROW [] synonym: "stimulation of axonogenesis" NARROW [] synonym: "up regulation of axonogenesis" EXACT [] synonym: "up-regulation of axonogenesis" EXACT [] synonym: "upregulation of axonogenesis" EXACT [] xref: Reactome:R-HSA-209563 "Axonal growth stimulation" is_a: GO:0031346 ! positive regulation of cell projection organization is_a: GO:0050769 ! positive regulation of neurogenesis is_a: GO:0050770 ! regulation of axonogenesis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0007409 ! positively regulates axonogenesis relationship: RO:0002213 GO:0007409 ! positively regulates axonogenesis [Term] id: GO:0050773 name: regulation of dendrite development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of dendrite development." [GOC:ai] is_a: GO:0010975 ! regulation of neuron projection development is_a: GO:0050793 ! regulation of developmental process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0016358 ! regulates dendrite development relationship: RO:0002211 GO:0016358 ! regulates dendrite development [Term] id: GO:0050774 name: negative regulation of dendrite morphogenesis namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of dendrite morphogenesis." [GOC:ai] synonym: "down regulation of dendrite morphogenesis" EXACT [] synonym: "down-regulation of dendrite morphogenesis" EXACT [] synonym: "downregulation of dendrite morphogenesis" EXACT [] synonym: "inhibition of dendrite morphogenesis" NARROW [] is_a: GO:0031345 ! negative regulation of cell projection organization is_a: GO:0048814 ! regulation of dendrite morphogenesis is_a: GO:0050768 ! negative regulation of neurogenesis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0048813 ! negatively regulates dendrite morphogenesis relationship: RO:0002212 GO:0048813 ! negatively regulates dendrite morphogenesis [Term] id: GO:0050775 name: positive regulation of dendrite morphogenesis namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of dendrite morphogenesis." [GOC:ai] synonym: "activation of dendrite morphogenesis" NARROW [] synonym: "stimulation of dendrite morphogenesis" NARROW [] synonym: "up regulation of dendrite morphogenesis" EXACT [] synonym: "up-regulation of dendrite morphogenesis" EXACT [] synonym: "upregulation of dendrite morphogenesis" EXACT [] is_a: GO:0010770 ! positive regulation of cell morphogenesis is_a: GO:0031346 ! positive regulation of cell projection organization is_a: GO:0048814 ! regulation of dendrite morphogenesis is_a: GO:0050769 ! positive regulation of neurogenesis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0048813 ! positively regulates dendrite morphogenesis relationship: RO:0002213 GO:0048813 ! positively regulates dendrite morphogenesis [Term] id: GO:0050776 name: regulation of immune response namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus." [GOC:ai] xref: Reactome:R-HSA-198933 "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell" is_a: GO:0002682 ! regulation of immune system process is_a: GO:0048583 ! regulation of response to stimulus intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0006955 ! regulates immune response relationship: RO:0002211 GO:0006955 ! regulates immune response property_value: RO:0002161 NCBITaxon:4895 [Term] id: GO:0050777 name: negative regulation of immune response namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus." [GOC:ai] synonym: "down regulation of immune response" EXACT [] synonym: "down-regulation of immune response" EXACT [] synonym: "downregulation of immune response" EXACT [] synonym: "inhibition of immune response" NARROW [] is_a: GO:0002683 ! negative regulation of immune system process is_a: GO:0048585 ! negative regulation of response to stimulus is_a: GO:0050776 ! regulation of immune response intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0006955 ! negatively regulates immune response relationship: RO:0002212 GO:0006955 ! negatively regulates immune response property_value: RO:0002161 NCBITaxon:4895 [Term] id: GO:0050778 name: positive regulation of immune response namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus." [GOC:ai] synonym: "stimulation of immune response" NARROW [] synonym: "up regulation of immune response" EXACT [] synonym: "up-regulation of immune response" EXACT [] synonym: "upregulation of immune response" EXACT [] is_a: GO:0002684 ! positive regulation of immune system process is_a: GO:0048584 ! positive regulation of response to stimulus is_a: GO:0050776 ! regulation of immune response intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0006955 ! positively regulates immune response relationship: RO:0002213 GO:0006955 ! positively regulates immune response property_value: RO:0002161 NCBITaxon:4895 [Term] id: GO:0050789 name: regulation of biological process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule." [GOC:ai, GOC:go_curators] subset: gocheck_do_not_annotate subset: goslim_candida subset: goslim_pir synonym: "regulation of physiological process" EXACT [] is_a: BFO:0000003 is_a: GO:0065007 ! biological regulation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0008150 ! regulates biological_process relationship: RO:0002211 GO:0008150 ! regulates biological_process [Term] id: GO:0050790 name: regulation of catalytic activity namespace: biological_process def: "Any process that modulates the activity of an enzyme." [GOC:ai, GOC:ebc, GOC:vw] subset: gocheck_obsoletion_candidate subset: goslim_chembl synonym: "regulation of enzyme activity" EXACT [] synonym: "regulation of metalloenzyme activity" NARROW [] is_a: GO:0065009 ! regulation of molecular function intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0003824 ! regulates catalytic activity relationship: RO:0002211 GO:0003824 ! regulates catalytic activity [Term] id: GO:0050793 name: regulation of developmental process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of development, the biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:go_curators] is_a: GO:0050789 ! regulation of biological process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0032502 ! regulates developmental process relationship: RO:0002211 GO:0032502 ! regulates developmental process [Term] id: GO:0050794 name: regulation of cellular process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:go_curators] subset: gocheck_do_not_annotate synonym: "regulation of cellular physiological process" EXACT [] is_a: GO:0050789 ! regulation of biological process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0009987 ! regulates cellular process relationship: RO:0002211 GO:0009987 ! regulates cellular process [Term] id: GO:0050795 name: regulation of behavior namespace: biological_process def: "Any process that modulates the frequency, rate or extent of behavior, the internally coordinated responses (actions or inactions) of whole living organisms (individuals or groups) to internal or external stimuli." [GOC:go_curators, GOC:pr] synonym: "regulation of behaviour" EXACT [] is_a: GO:0051239 ! regulation of multicellular organismal process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0007610 ! regulates behavior relationship: RO:0002211 GO:0007610 ! regulates behavior [Term] id: GO:0050796 name: regulation of insulin secretion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the regulated release of insulin." [GOC:ai] xref: Reactome:R-HSA-422356 "Regulation of insulin secretion" is_a: GO:0050708 ! regulation of protein secretion is_a: GO:0090276 ! regulation of peptide hormone secretion intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0030073 ! regulates insulin secretion relationship: RO:0002211 GO:0030073 ! regulates insulin secretion [Term] id: GO:0050801 name: monoatomic ion homeostasis namespace: biological_process def: "Any process involved in the maintenance of an internal steady state of monoatomic ions within an organism or cell. Monatomic ions (also called simple ions) are ions consisting of exactly one atom." [GOC:ai] synonym: "electrolyte homeostasis" RELATED [] synonym: "ion homeostasis" BROAD [] synonym: "negative regulation of crystal formation" RELATED [] synonym: "regulation of ion homeostasis" RELATED [] is_a: GO:0048878 ! chemical homeostasis intersection_of: GO:0048878 ! chemical homeostasis intersection_of: RO:0002332 CHEBI:24867 ! regulates levels of relationship: RO:0002332 CHEBI:24867 ! regulates levels of property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/24455" xsd:anyURI [Term] id: GO:0050803 name: regulation of synapse structure or activity namespace: biological_process def: "Any process that modulates the physical form or the activity of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell)." [GOC:ai] is_a: GO:0065008 ! regulation of biological quality relationship: RO:0002162 NCBITaxon:6072 ! in taxon Eumetazoa [Term] id: GO:0050804 name: modulation of chemical synaptic transmission namespace: biological_process def: "Any process that modulates the frequency or amplitude of synaptic transmission, the process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse. Amplitude, in this case, refers to the change in postsynaptic membrane potential due to a single instance of synaptic transmission." [GOC:ai] subset: goslim_synapse synonym: "modulation of synaptic transmission" BROAD [] synonym: "regulation of chemical synaptic transmission" EXACT [] synonym: "regulation of synaptic transmission" EXACT [] is_a: GO:0099177 ! regulation of trans-synaptic signaling intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0007268 ! regulates chemical synaptic transmission relationship: RO:0002211 GO:0007268 ! regulates chemical synaptic transmission [Term] id: GO:0050805 name: negative regulation of synaptic transmission namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of synaptic transmission, the process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse." [GOC:ai] synonym: "down regulation of synaptic transmission" EXACT [] synonym: "down-regulation of synaptic transmission" EXACT [] synonym: "downregulation of synaptic transmission" EXACT [] synonym: "inhibition of synaptic transmission" NARROW [] is_a: GO:0010648 ! negative regulation of cell communication is_a: GO:0023057 ! negative regulation of signaling is_a: GO:0050804 ! modulation of chemical synaptic transmission intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0007268 ! negatively regulates chemical synaptic transmission relationship: RO:0002212 GO:0007268 ! negatively regulates chemical synaptic transmission [Term] id: GO:0050806 name: positive regulation of synaptic transmission namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of synaptic transmission, the process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse." [GOC:ai] synonym: "activation of synaptic transmission" NARROW [] synonym: "stimulation of synaptic transmission" NARROW [] synonym: "up regulation of synaptic transmission" EXACT [] synonym: "up-regulation of synaptic transmission" EXACT [] synonym: "upregulation of synaptic transmission" EXACT [] is_a: GO:0010647 ! positive regulation of cell communication is_a: GO:0023056 ! positive regulation of signaling is_a: GO:0050804 ! modulation of chemical synaptic transmission intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0007268 ! positively regulates chemical synaptic transmission relationship: RO:0002213 GO:0007268 ! positively regulates chemical synaptic transmission [Term] id: GO:0050807 name: regulation of synapse organization namespace: biological_process def: "Any process that modulates the physical form of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell)." [GOC:ai, GOC:dph, GOC:tb] subset: goslim_synapse synonym: "regulation of synapse organisation" EXACT [GOC:mah] synonym: "regulation of synapse organization and biogenesis" RELATED [GOC:mah] synonym: "regulation of synapse structure" EXACT [] is_a: GO:0051128 ! regulation of cellular component organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0050808 ! regulates synapse organization relationship: BFO:0000050 GO:0050803 ! part of regulation of synapse structure or activity relationship: RO:0002211 GO:0050808 ! regulates synapse organization [Term] id: GO:0050808 name: synapse organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell)." [GOC:ai, GOC:pr] subset: goslim_drosophila subset: goslim_synapse synonym: "synapse development" RELATED [GOC:aruk] synonym: "synapse morphogenesis" RELATED [GOC:BHF] synonym: "synapse organisation" EXACT [] synonym: "synapse organization and biogenesis" RELATED [GOC:mah] is_a: GO:0034330 ! cell junction organization intersection_of: GO:0009987 ! cellular process intersection_of: RO:0002592 GO:0045202 ! results in organization of synapse relationship: RO:0002592 GO:0045202 ! results in organization of synapse [Term] id: GO:0050810 name: regulation of steroid biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus." [GOC:ai] synonym: "regulation of steroid anabolism" EXACT [] synonym: "regulation of steroid biosynthesis" EXACT [] synonym: "regulation of steroid formation" EXACT [] synonym: "regulation of steroid synthesis" EXACT [] synonym: "regulation of steroidogenesis" EXACT [] is_a: GO:0019218 ! regulation of steroid metabolic process is_a: GO:0046890 ! regulation of lipid biosynthetic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0006694 ! regulates steroid biosynthetic process relationship: RO:0002211 GO:0006694 ! regulates steroid biosynthetic process [Term] id: GO:0050817 name: coagulation namespace: biological_process def: "The process in which a fluid solution, or part of it, changes into a solid or semisolid mass." [ISBN:0198506732] subset: goslim_pir synonym: "clotting" EXACT [] is_a: GO:0032501 ! multicellular organismal process property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0050818 name: regulation of coagulation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of coagulation, the process in which a fluid solution, or part of it, changes into a solid or semisolid mass." [GOC:ai] synonym: "regulation of clotting" EXACT [] is_a: GO:0051239 ! regulation of multicellular organismal process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0050817 ! regulates coagulation relationship: RO:0002211 GO:0050817 ! regulates coagulation property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0050819 name: negative regulation of coagulation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of coagulation." [GOC:ai] synonym: "anticoagulant activity" RELATED [] synonym: "down regulation of coagulation" EXACT [] synonym: "down-regulation of coagulation" EXACT [] synonym: "downregulation of coagulation" EXACT [] synonym: "inhibition of coagulation" NARROW [] synonym: "negative regulation of clotting" EXACT [] is_a: GO:0050818 ! regulation of coagulation is_a: GO:0051241 ! negative regulation of multicellular organismal process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0050817 ! negatively regulates coagulation relationship: RO:0002212 GO:0050817 ! negatively regulates coagulation property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0050820 name: positive regulation of coagulation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of coagulation." [GOC:ai] synonym: "activation of coagulation" NARROW [] synonym: "positive regulation of clotting" EXACT [] synonym: "stimulation of coagulation" NARROW [] synonym: "up regulation of coagulation" EXACT [] synonym: "up-regulation of coagulation" EXACT [] synonym: "upregulation of coagulation" EXACT [] is_a: GO:0050818 ! regulation of coagulation is_a: GO:0051240 ! positive regulation of multicellular organismal process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0050817 ! positively regulates coagulation relationship: RO:0002213 GO:0050817 ! positively regulates coagulation property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0050825 name: ice binding namespace: molecular_function def: "Binding to ice, water reduced to the solid state by cold temperature. It is a white or transparent colorless substance, crystalline, brittle, and viscoidal." [GOC:curators] synonym: "ice crystal binding" EXACT [] synonym: "ice nucleation inhibitor activity" RELATED [] is_a: BFO:0000003 is_a: GO:0036094 ! small molecule binding intersection_of: GO:0036094 ! small molecule binding intersection_of: RO:0004009 CHEBI:15377 ! has primary input relationship: RO:0004009 CHEBI:15377 ! has primary input [Term] id: GO:0050832 name: defense response to fungus namespace: biological_process def: "Reactions triggered in response to the presence of a fungus that act to protect the cell or organism." [GOC:ai] synonym: "defence response to fungi" EXACT [] synonym: "defence response to fungus" EXACT [] synonym: "defense response to fungi" EXACT [] synonym: "defense response to fungus, incompatible interaction" NARROW [] synonym: "resistance response to pathogenic fungi" NARROW [] synonym: "resistance response to pathogenic fungus" NARROW [] synonym: "response to parasitic fungi" NARROW [] synonym: "response to parasitic fungus" NARROW [] is_a: GO:0006952 ! defense response is_a: GO:0009620 ! response to fungus intersection_of: GO:0006952 ! defense response intersection_of: RO:0004009 NCBITaxon:4751 ! has primary input Fungi property_value: RO:0002161 NCBITaxon:4895 [Term] id: GO:0050839 name: cell adhesion molecule binding namespace: molecular_function def: "Binding to a cell adhesion molecule." [GOC:ai] synonym: "adhesive extracellular matrix constituent" RELATED [] synonym: "CAM binding" EXACT [] synonym: "cell adhesion molecule activity" RELATED [] synonym: "cell adhesion receptor activity" RELATED [] is_a: GO:0005515 ! protein binding [Term] id: GO:0050840 name: extracellular matrix binding namespace: molecular_function def: "Binding to a component of the extracellular matrix." [GOC:ai] subset: goslim_chembl subset: goslim_pir synonym: "adhesive extracellular matrix constituent" RELATED [] synonym: "extracellular matrix constituent binding" EXACT [] is_a: BFO:0000003 is_a: GO:0005488 ! binding intersection_of: GO:0005488 ! binding intersection_of: RO:0004009 GO:0031012 ! has primary input extracellular matrix relationship: RO:0004009 GO:0031012 ! has primary input extracellular matrix [Term] id: GO:0050848 name: regulation of calcium-mediated signaling namespace: biological_process def: "Any process that modulates the frequency, rate or extent of calcium-mediated signaling, the process in which a cell uses calcium ions to convert an extracellular signal into a response." [GOC:ai] synonym: "regulation of calcium-mediated signalling" EXACT [] is_a: GO:1902531 ! regulation of intracellular signal transduction intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0019722 ! regulates calcium-mediated signaling relationship: RO:0002211 GO:0019722 ! regulates calcium-mediated signaling [Term] id: GO:0050849 name: negative regulation of calcium-mediated signaling namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of calcium-mediated signaling." [GOC:ai, PMID:11696592] synonym: "down regulation of calcium-mediated signaling" EXACT [] synonym: "down-regulation of calcium-mediated signaling" EXACT [] synonym: "downregulation of calcium-mediated signaling" EXACT [] synonym: "inhibition of calcium-mediated signaling" NARROW [] synonym: "negative regulation of calcium-mediated signalling" EXACT [] is_a: GO:0050848 ! regulation of calcium-mediated signaling is_a: GO:1902532 ! negative regulation of intracellular signal transduction intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0019722 ! negatively regulates calcium-mediated signaling relationship: RO:0002212 GO:0019722 ! negatively regulates calcium-mediated signaling [Term] id: GO:0050850 name: positive regulation of calcium-mediated signaling namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of calcium-mediated signaling." [GOC:ai] synonym: "activation of calcium-mediated signaling" NARROW [] synonym: "positive regulation of calcium-mediated signalling" EXACT [] synonym: "stimulation of calcium-mediated signaling" NARROW [] synonym: "up regulation of calcium-mediated signaling" EXACT [] synonym: "up-regulation of calcium-mediated signaling" EXACT [] synonym: "upregulation of calcium-mediated signaling" EXACT [] is_a: GO:0050848 ! regulation of calcium-mediated signaling is_a: GO:1902533 ! positive regulation of intracellular signal transduction intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0019722 ! positively regulates calcium-mediated signaling relationship: RO:0002213 GO:0019722 ! positively regulates calcium-mediated signaling [Term] id: GO:0050863 name: regulation of T cell activation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of T cell activation." [GOC:ai] synonym: "regulation of T lymphocyte activation" EXACT [] synonym: "regulation of T-cell activation" EXACT [] synonym: "regulation of T-lymphocyte activation" EXACT [] is_a: GO:0051249 ! regulation of lymphocyte activation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0042110 ! regulates T cell activation relationship: RO:0002211 GO:0042110 ! regulates T cell activation [Term] id: GO:0050864 name: regulation of B cell activation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of B cell activation." [GOC:ai] synonym: "regulation of B lymphocyte activation" EXACT [] synonym: "regulation of B-cell activation" EXACT [] synonym: "regulation of B-lymphocyte activation" EXACT [] is_a: GO:0051249 ! regulation of lymphocyte activation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0042113 ! regulates B cell activation relationship: RO:0002211 GO:0042113 ! regulates B cell activation [Term] id: GO:0050865 name: regulation of cell activation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cell activation, the change in the morphology or behavior of a cell resulting from exposure to an activating factor such as a cellular or soluble ligand." [GOC:ai] is_a: GO:0050794 ! regulation of cellular process is_a: GO:0051239 ! regulation of multicellular organismal process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0001775 ! regulates cell activation relationship: RO:0002211 GO:0001775 ! regulates cell activation [Term] id: GO:0050866 name: negative regulation of cell activation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cell activation." [GOC:ai] synonym: "down regulation of cell activation" EXACT [] synonym: "down-regulation of cell activation" EXACT [] synonym: "downregulation of cell activation" EXACT [] synonym: "inhibition of cell activation" NARROW [] is_a: GO:0048523 ! negative regulation of cellular process is_a: GO:0050865 ! regulation of cell activation is_a: GO:0051241 ! negative regulation of multicellular organismal process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0001775 ! negatively regulates cell activation relationship: RO:0002212 GO:0001775 ! negatively regulates cell activation [Term] id: GO:0050867 name: positive regulation of cell activation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of activation." [GOC:ai] synonym: "activation of cell activation" NARROW [] synonym: "stimulation of cell activation" NARROW [] synonym: "up regulation of cell activation" EXACT [] synonym: "up-regulation of cell activation" EXACT [] synonym: "upregulation of cell activation" EXACT [] is_a: GO:0048522 ! positive regulation of cellular process is_a: GO:0050865 ! regulation of cell activation is_a: GO:0051240 ! positive regulation of multicellular organismal process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0001775 ! positively regulates cell activation relationship: RO:0002213 GO:0001775 ! positively regulates cell activation [Term] id: GO:0050868 name: negative regulation of T cell activation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of T cell activation." [GOC:ai] synonym: "down regulation of T cell activation" EXACT [] synonym: "down-regulation of T cell activation" EXACT [] synonym: "downregulation of T cell activation" EXACT [] synonym: "inhibition of T cell activation" NARROW [] synonym: "negative regulation of T lymphocyte activation" EXACT [] synonym: "negative regulation of T-cell activation" EXACT [] synonym: "negative regulation of T-lymphocyte activation" EXACT [] is_a: GO:0050863 ! regulation of T cell activation is_a: GO:0051250 ! negative regulation of lymphocyte activation is_a: GO:1903038 ! negative regulation of leukocyte cell-cell adhesion intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0042110 ! negatively regulates T cell activation relationship: RO:0002212 GO:0042110 ! negatively regulates T cell activation [Term] id: GO:0050869 name: negative regulation of B cell activation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of B cell activation." [GOC:ai] synonym: "down regulation of B cell activation" EXACT [] synonym: "down-regulation of B cell activation" EXACT [] synonym: "downregulation of B cell activation" EXACT [] synonym: "inhibition of B cell activation" NARROW [] synonym: "negative regulation of B lymphocyte activation" EXACT [] synonym: "negative regulation of B-cell activation" EXACT [] synonym: "negative regulation of B-lymphocyte activation" EXACT [] is_a: GO:0050864 ! regulation of B cell activation is_a: GO:0051250 ! negative regulation of lymphocyte activation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0042113 ! negatively regulates B cell activation relationship: RO:0002212 GO:0042113 ! negatively regulates B cell activation [Term] id: GO:0050870 name: positive regulation of T cell activation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of T cell activation." [GOC:ai] synonym: "activation of T cell activation" NARROW [] synonym: "positive regulation of T lymphocyte activation" EXACT [] synonym: "positive regulation of T-cell activation" EXACT [] synonym: "positive regulation of T-lymphocyte activation" EXACT [] synonym: "stimulation of T cell activation" NARROW [] synonym: "up regulation of T cell activation" EXACT [] synonym: "up-regulation of T cell activation" EXACT [] synonym: "upregulation of T cell activation" EXACT [] is_a: GO:0050863 ! regulation of T cell activation is_a: GO:0051251 ! positive regulation of lymphocyte activation is_a: GO:1903039 ! positive regulation of leukocyte cell-cell adhesion intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0042110 ! positively regulates T cell activation relationship: RO:0002213 GO:0042110 ! positively regulates T cell activation [Term] id: GO:0050871 name: positive regulation of B cell activation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of B cell activation." [GOC:ai] synonym: "activation of B cell activation" NARROW [] synonym: "positive regulation of B lymphocyte activation" EXACT [] synonym: "positive regulation of B-cell activation" EXACT [] synonym: "positive regulation of B-lymphocyte activation" EXACT [] synonym: "stimulation of B cell activation" NARROW [] synonym: "up regulation of B cell activation" EXACT [] synonym: "up-regulation of B cell activation" EXACT [] synonym: "upregulation of B cell activation" EXACT [] is_a: GO:0050864 ! regulation of B cell activation is_a: GO:0051251 ! positive regulation of lymphocyte activation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0042113 ! positively regulates B cell activation relationship: RO:0002213 GO:0042113 ! positively regulates B cell activation [Term] id: GO:0050872 name: white fat cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a white adipocyte, an animal connective tissue cell involved in energy storage. White adipocytes have cytoplasmic lipids arranged in a unique vacuole." [PMID:12508945] synonym: "white adipocyte cell differentiation" EXACT [] synonym: "white adipocyte differentiation" EXACT [] xref: Reactome:R-HSA-381340 "Transcriptional regulation of white adipocyte differentiation" is_a: GO:0045444 ! fat cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000448 ! results in acquisition of features of white adipocyte relationship: RO:0002315 CL:0000448 ! results in acquisition of features of white adipocyte [Term] id: GO:0050873 name: brown fat cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a brown adipocyte, an animal connective tissue cell involved in adaptive thermogenesis. Brown adipocytes contain multiple small droplets of triglycerides and a high number of mitochondria." [PMID:12588810] synonym: "brown adipocyte cell differentiation" EXACT [] synonym: "brown adipocyte differentiation" EXACT [] is_a: GO:0045444 ! fat cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000449 ! results in acquisition of features of brown adipocyte relationship: RO:0002315 CL:0000449 ! results in acquisition of features of brown adipocyte property_value: RO:0002161 NCBITaxon:8782 [Term] id: GO:0050877 name: nervous system process namespace: biological_process def: "An organ system process carried out by any of the organs or tissues of the neurological system." [GOC:ai, GOC:mtg_cardio] subset: goslim_agr subset: goslim_chembl subset: goslim_flybase_ribbon subset: goslim_generic subset: goslim_pir synonym: "neurological system process" EXACT [] synonym: "neurophysiological process" EXACT [] synonym: "pan-neural process" RELATED [] is_a: BFO:0000003 is_a: GO:0003008 ! system process intersection_of: GO:0003008 ! system process intersection_of: has_participant UBERON:0001016 ! nervous system relationship: has_participant UBERON:0001016 ! nervous system relationship: RO:0002162 NCBITaxon:33208 ! in taxon Metazoa property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/13824" xsd:anyURI [Term] id: GO:0050878 name: regulation of body fluid levels namespace: biological_process def: "Any process that modulates the levels of body fluids." [GOC:ai, GOC:dph, GOC:tb] subset: goslim_pir is_a: GO:0065008 ! regulation of biological quality [Term] id: GO:0050879 name: multicellular organismal movement namespace: biological_process def: "Any physiological process involved in changing the position of a multicellular organism or an anatomical part of a multicellular organism." [GOC:dph, GOC:mtg_muscle, GOC:tb] subset: goslim_pir is_a: GO:0032501 ! multicellular organismal process property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0050881 name: musculoskeletal movement namespace: biological_process def: "The movement of an organism or part of an organism using mechanoreceptors, the nervous system, striated muscle and/or the skeletal system." [GOC:dph] is_a: GO:0050879 ! multicellular organismal movement is_a: GO:0050905 ! neuromuscular process [Term] id: GO:0050884 name: neuromuscular process controlling posture namespace: biological_process def: "Any process in which an organism voluntarily modulates its posture, the alignment of its anatomical parts." [GOC:dph, GOC:tb] synonym: "regulation of posture" EXACT [] is_a: GO:0050905 ! neuromuscular process relationship: BFO:0000051 GO:0050881 ! has part musculoskeletal movement [Term] id: GO:0050885 name: neuromuscular process controlling balance namespace: biological_process def: "Any process that an organism uses to control its balance, the orientation of the organism (or the head of the organism) in relation to the source of gravity. In humans and animals, balance is perceived through visual cues, the labyrinth system of the inner ears and information from skin pressure receptors and muscle and joint receptors." [GOC:ai, GOC:dph] synonym: "regulation of balance" RELATED [] is_a: GO:0050905 ! neuromuscular process relationship: BFO:0000051 GO:0050881 ! has part musculoskeletal movement [Term] id: GO:0050886 name: endocrine process namespace: biological_process def: "The process that involves the secretion of or response to endocrine hormones. An endocrine hormone is a hormone released into the circulatory system." [ISBN:0721662544] subset: goslim_generic subset: goslim_pir synonym: "endocrine physiological process" EXACT [] synonym: "endocrine physiology" EXACT [] is_a: GO:0003008 ! system process property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0050890 name: cognition namespace: biological_process def: "The operation of the mind by which an organism becomes aware of objects of thought or perception; it includes the mental activities associated with thinking, learning, and memory." [ISBN:0721619908] subset: goslim_drosophila xref: Wikipedia:Cognition is_a: GO:0050877 ! nervous system process [Term] id: GO:0050891 name: multicellular organismal-level water homeostasis namespace: biological_process def: "A chemical homeostatic process involved in the maintenance of a steady state level of water within extracellular body fluids, such as blood, xylem or phloem, of a multicellular organism. This is distinct from maintenance of cellular homeostasis, which occurs within a cell." [GOC:dph, GOC:tb] synonym: "body fluid osmoregulation" RELATED [GOC:dph, GOC:tb] synonym: "multicellular organismal water homeostasis" EXACT [] is_a: GO:0050878 ! regulation of body fluid levels is_a: GO:0140962 ! multicellular organismal-level chemical homeostasis intersection_of: GO:0048871 ! multicellular organismal-level homeostasis intersection_of: RO:0002332 CHEBI:15377 ! regulates levels of relationship: RO:0002332 CHEBI:15377 ! regulates levels of property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/24554" xsd:anyURI property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0050893 name: sensory processing namespace: biological_process def: "Any neural process required for an organism to sense and interpret the dimensions of a sensory experience: modality, location, intensity and affect." [GOC:dph, ISBN:0721662544] is_a: GO:0050890 ! cognition relationship: BFO:0000050 GO:0007600 ! part of sensory perception [Term] id: GO:0050896 name: response to stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. The process begins with detection of the stimulus and ends with a change in state or activity or the cell or organism." [GOC:ai, GOC:bf] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_annotate subset: goslim_agr subset: goslim_flybase_ribbon subset: goslim_mouse subset: goslim_pir subset: goslim_prokaryote subset: goslim_prokaryote_ribbon synonym: "physiological response to stimulus" EXACT [] is_a: GO:0008150 ! biological_process [Term] id: GO:0050900 name: leukocyte migration namespace: biological_process def: "The movement of a leukocyte within or between different tissues and organs of the body." [GOC:add, ISBN:0781735149, PMID:14680625, PMID:14708592, PMID:7507411, PMID:8600538] synonym: "immune cell migration" EXACT [] synonym: "immune cell trafficking" EXACT [] synonym: "leucocyte migration" EXACT [] synonym: "leucocyte trafficking" EXACT [] synonym: "leukocyte trafficking" EXACT [] xref: Reactome:R-HSA-202733 "Cell surface interactions at the vascular wall" is_a: BFO:0000003 is_a: GO:0002376 ! immune system process is_a: GO:0016477 ! cell migration intersection_of: GO:0016477 ! cell migration intersection_of: RO:0002565 CL:0000738 ! results in movement of leukocyte relationship: RO:0002162 NCBITaxon:7742 ! in taxon Vertebrata relationship: RO:0002565 CL:0000738 ! results in movement of leukocyte [Term] id: GO:0050905 name: neuromuscular process namespace: biological_process def: "Any process pertaining to the functions of the nervous and muscular systems of an organism." [GOC:ai] synonym: "neuromotor process" EXACT [] synonym: "neuromuscular physiological process" EXACT [] is_a: GO:0050877 ! nervous system process [Term] id: GO:0050906 name: detection of stimulus involved in sensory perception namespace: biological_process def: "The series of events involved in sensory perception in which a sensory stimulus is received and converted into a molecular signal." [GOC:ai, GOC:dos, GOC:dph] synonym: "sensory detection of stimulus" EXACT [] synonym: "sensory perception, sensory transduction of stimulus" EXACT [] synonym: "sensory perception, stimulus detection" EXACT [] synonym: "sensory transduction" EXACT [] xref: Wikipedia:Transduction_(physiology) is_a: GO:0051606 ! detection of stimulus intersection_of: GO:0051606 ! detection of stimulus intersection_of: BFO:0000050 GO:0007600 ! part of sensory perception relationship: BFO:0000050 GO:0007600 ! part of sensory perception [Term] id: GO:0050907 name: detection of chemical stimulus involved in sensory perception namespace: biological_process def: "The series of events in which a chemical stimulus is received and converted into a molecular signal as part of sensory perception." [GOC:ai, GOC:dos] synonym: "sensory detection of chemical stimulus" EXACT [] synonym: "sensory detection of chemical stimulus during sensory perception" EXACT [] synonym: "sensory perception, sensory detection of chemical stimulus" EXACT [] synonym: "sensory perception, sensory transduction of chemical stimulus" EXACT [] synonym: "sensory transduction of chemical stimulus" EXACT [] synonym: "sensory transduction of chemical stimulus during sensory perception" EXACT [] is_a: GO:0009593 ! detection of chemical stimulus is_a: GO:0050906 ! detection of stimulus involved in sensory perception intersection_of: GO:0009593 ! detection of chemical stimulus intersection_of: BFO:0000050 GO:0007600 ! part of sensory perception relationship: BFO:0000050 GO:0007606 ! part of sensory perception of chemical stimulus [Term] id: GO:0050908 name: detection of light stimulus involved in visual perception namespace: biological_process def: "The series of events involved in visual perception in which a light stimulus is received and converted into a molecular signal." [GOC:ai, GOC:dos] synonym: "sensory detection of light during visual perception" EXACT [] synonym: "sensory detection of light stimulus during visual perception" EXACT [] synonym: "sensory transduction of light during visual perception" EXACT [] synonym: "sensory transduction of light stimulus during visual perception" EXACT [] synonym: "visual perception, detection of light stimulus" EXACT [] synonym: "visual perception, sensory transduction during perception of light" EXACT [] synonym: "visual perception, sensory transduction of light stimulus" EXACT [] is_a: GO:0050962 ! detection of light stimulus involved in sensory perception intersection_of: GO:0009583 ! detection of light stimulus intersection_of: BFO:0000050 GO:0007601 ! part of visual perception relationship: BFO:0000050 GO:0007601 ! part of visual perception [Term] id: GO:0050909 name: sensory perception of taste namespace: biological_process def: "The series of events required for an organism to receive a gustatory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Gustation involves the direct detection of chemical composition, usually through contact with chemoreceptor cells. This is a neurological process." [GOC:ai] synonym: "gustation" EXACT [] synonym: "sense of taste" EXACT [] synonym: "taste" EXACT [] synonym: "taste perception" EXACT [] xref: Reactome:R-HSA-9717189 "Sensory perception of taste" xref: Wikipedia:Taste is_a: GO:0007606 ! sensory perception of chemical stimulus [Term] id: GO:0050910 name: detection of mechanical stimulus involved in sensory perception of sound namespace: biological_process def: "The series of events involved in the perception of sound vibration in which the vibration is received and converted into a molecular signal." [GOC:ai] synonym: "detection of sound" EXACT [] synonym: "hearing, sensory transduction of sound" EXACT [] synonym: "perception of sound, detection of mechanical stimulus" EXACT [] synonym: "perception of sound, sensory detection of mechanical stimulus" EXACT [] synonym: "perception of sound, sensory transduction of mechanical stimulus" EXACT [] synonym: "sensory detection of mechanical stimulus during perception of sound" EXACT [] synonym: "sensory transduction of mechanical stimulus during perception of sound" EXACT [] synonym: "sensory transduction of sound" EXACT [] is_a: GO:0050877 ! nervous system process is_a: GO:0050974 ! detection of mechanical stimulus involved in sensory perception intersection_of: GO:0050982 ! detection of mechanical stimulus intersection_of: BFO:0000050 GO:0007605 ! part of sensory perception of sound relationship: BFO:0000050 GO:0007605 ! part of sensory perception of sound [Term] id: GO:0050911 name: detection of chemical stimulus involved in sensory perception of smell namespace: biological_process def: "The series of events involved in the perception of smell in which an olfactory chemical stimulus is received and converted into a molecular signal." [GOC:ai] synonym: "perception of smell, detection of chemical stimulus" EXACT [] synonym: "perception of smell, sensory detection of chemical stimulus" EXACT [] synonym: "perception of smell, sensory transduction of chemical stimulus" EXACT [] synonym: "sensory detection of chemical stimulus during perception of smell" EXACT [] synonym: "sensory detection of scent" EXACT [] synonym: "sensory detection of smell" EXACT [] synonym: "sensory transduction of chemical stimulus during perception of smell" EXACT [] synonym: "sensory transduction of scent" EXACT [] synonym: "sensory transduction of smell" EXACT [] is_a: GO:0050907 ! detection of chemical stimulus involved in sensory perception intersection_of: GO:0009593 ! detection of chemical stimulus intersection_of: BFO:0000050 GO:0007608 ! part of sensory perception of smell relationship: BFO:0000050 GO:0007608 ! part of sensory perception of smell [Term] id: GO:0050912 name: detection of chemical stimulus involved in sensory perception of taste namespace: biological_process def: "The series of events involved in the perception of taste in which a gustatory chemical stimulus is received and converted into a molecular signal." [GOC:ai] synonym: "perception of taste, detection of chemical stimulus" EXACT [] synonym: "perception of taste, sensory detection of chemical stimulus" EXACT [] synonym: "perception of taste, sensory transduction of chemical stimulus" EXACT [] synonym: "sensory detection of chemical stimulus during perception of taste" EXACT [] synonym: "sensory detection of taste" EXACT [] synonym: "sensory transduction of chemical stimulus during perception of taste" EXACT [] synonym: "sensory transduction of taste" EXACT [] synonym: "taste perception" BROAD [] is_a: GO:0050907 ! detection of chemical stimulus involved in sensory perception intersection_of: GO:0009593 ! detection of chemical stimulus intersection_of: BFO:0000050 GO:0050909 ! part of sensory perception of taste relationship: BFO:0000050 GO:0050909 ! part of sensory perception of taste [Term] id: GO:0050920 name: regulation of chemotaxis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the directed movement of a motile cell or organism in response to a specific chemical concentration gradient." [GOC:ai] is_a: GO:0032101 ! regulation of response to external stimulus is_a: GO:0040012 ! regulation of locomotion intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0006935 ! regulates chemotaxis relationship: RO:0002211 GO:0006935 ! regulates chemotaxis property_value: RO:0002161 NCBITaxon:451864 [Term] id: GO:0050921 name: positive regulation of chemotaxis namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the directed movement of a motile cell or organism in response to a specific chemical concentration gradient." [GOC:ai] synonym: "activation of chemotaxis" NARROW [] synonym: "stimulation of chemotaxis" NARROW [] synonym: "up regulation of chemotaxis" EXACT [] synonym: "up-regulation of chemotaxis" EXACT [] synonym: "upregulation of chemotaxis" EXACT [] is_a: GO:0032103 ! positive regulation of response to external stimulus is_a: GO:0040017 ! positive regulation of locomotion is_a: GO:0050920 ! regulation of chemotaxis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0006935 ! positively regulates chemotaxis relationship: RO:0002213 GO:0006935 ! positively regulates chemotaxis property_value: RO:0002161 NCBITaxon:451864 [Term] id: GO:0050922 name: negative regulation of chemotaxis namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of a motile cell or organism in response to a specific chemical concentration gradient." [GOC:ai] synonym: "down regulation of chemotaxis" EXACT [] synonym: "down-regulation of chemotaxis" EXACT [] synonym: "downregulation of chemotaxis" EXACT [] synonym: "inhibition of chemotaxis" NARROW [] is_a: GO:0032102 ! negative regulation of response to external stimulus is_a: GO:0040013 ! negative regulation of locomotion is_a: GO:0050920 ! regulation of chemotaxis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0006935 ! negatively regulates chemotaxis relationship: RO:0002212 GO:0006935 ! negatively regulates chemotaxis property_value: RO:0002161 NCBITaxon:451864 [Term] id: GO:0050931 name: pigment cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires the specialized features of a pigmented cell, such as a melanocyte." [GOC:dgh] comment: Note that the chromatophore mentioned here is distinct from the pigment bearing structure found in certain photosynthetic bacteria and cyanobacteria. It is also different from the plant chromoplast, which is also sometimes called a chromatophore. synonym: "chromatophore differentiation" EXACT [] synonym: "pigmented cell differentiation" EXACT [] is_a: GO:0030154 ! cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000147 ! results in acquisition of features of pigment cell relationship: BFO:0000050 GO:0048066 ! part of developmental pigmentation relationship: RO:0002315 CL:0000147 ! results in acquisition of features of pigment cell [Term] id: GO:0050932 name: regulation of pigment cell differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of pigmented cell differentiation." [GOC:ai] is_a: GO:0045595 ! regulation of cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0050931 ! regulates pigment cell differentiation relationship: RO:0002211 GO:0050931 ! regulates pigment cell differentiation [Term] id: GO:0050935 name: iridophore differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires the specialized features of an iridophore. Iridophores are pigment cells derived from the neural crest. They contain guanidine or other purine crystals deposited in stacks called reflecting platets or iridisomes. This gives them a silver, gold, or iridescent appearance." [GOC:jid, GOC:mh, PMID:11858836] synonym: "iridophore cell differentiation" EXACT [] is_a: GO:0050931 ! pigment cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000431 ! results in acquisition of features of iridophore relationship: RO:0002162 NCBITaxon:89593 ! in taxon Craniata relationship: RO:0002315 CL:0000431 ! results in acquisition of features of iridophore [Term] id: GO:0050936 name: xanthophore differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires the specialized features of a xanthophore cell. Xanthophores are pigment cells derived from the neural crest. They contain pteridine and/or carotenoid pigments in structures called pterinosomes or xanthosomes. This makes them yellow to orange in appearance." [GOC:jid, GOC:mh, PMID:11858836] comment: Note that this term refers to xanthophores in the sense of specialized pigment-producing cells, and should not be confused with the cellular component term 'xanthophore ; GO:0031633', which refers to a subcellular structure. synonym: "xanthophore cell differentiation" EXACT [] is_a: GO:0050931 ! pigment cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000430 ! results in acquisition of features of xanthophore cell relationship: RO:0002162 NCBITaxon:89593 ! in taxon Craniata relationship: RO:0002315 CL:0000430 ! results in acquisition of features of xanthophore cell [Term] id: GO:0050937 name: regulation of iridophore differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of iridophore differentiation." [GOC:ai] is_a: GO:0050932 ! regulation of pigment cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0050935 ! regulates iridophore differentiation relationship: RO:0002211 GO:0050935 ! regulates iridophore differentiation [Term] id: GO:0050938 name: regulation of xanthophore differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of xanthophore differentiation." [GOC:ai] comment: Note that this term refers to xanthophores in the sense of specialized pigment-producing cells, and should not be confused with the cellular component term 'xanthophore ; GO:0031633', which refers to a subcellular structure. is_a: GO:0050932 ! regulation of pigment cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0050936 ! regulates xanthophore differentiation relationship: RO:0002211 GO:0050936 ! regulates xanthophore differentiation [Term] id: GO:0050941 name: negative regulation of pigment cell differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of pigment cell differentiation." [GOC:ai] synonym: "down regulation of pigment cell differentiation" EXACT [] synonym: "down-regulation of pigment cell differentiation" EXACT [] synonym: "downregulation of pigment cell differentiation" EXACT [] synonym: "inhibition of pigment cell differentiation" NARROW [] is_a: GO:0045596 ! negative regulation of cell differentiation is_a: GO:0048086 ! negative regulation of developmental pigmentation is_a: GO:0050932 ! regulation of pigment cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0050931 ! negatively regulates pigment cell differentiation relationship: RO:0002212 GO:0050931 ! negatively regulates pigment cell differentiation [Term] id: GO:0050942 name: positive regulation of pigment cell differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of pigment cell differentiation." [GOC:ai] synonym: "activation of pigment cell differentiation" NARROW [] synonym: "stimulation of pigment cell differentiation" NARROW [] synonym: "up regulation of pigment cell differentiation" EXACT [] synonym: "up-regulation of pigment cell differentiation" EXACT [] synonym: "upregulation of pigment cell differentiation" EXACT [] is_a: GO:0045597 ! positive regulation of cell differentiation is_a: GO:0048087 ! positive regulation of developmental pigmentation is_a: GO:0050932 ! regulation of pigment cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0050931 ! positively regulates pigment cell differentiation relationship: RO:0002213 GO:0050931 ! positively regulates pigment cell differentiation [Term] id: GO:0050943 name: negative regulation of iridophore differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of iridophore differentiation." [GOC:ai] synonym: "down regulation of iridophore differentiation" EXACT [] synonym: "down-regulation of iridophore differentiation" EXACT [] synonym: "downregulation of iridophore differentiation" EXACT [] synonym: "inhibition of iridophore differentiation" NARROW [] is_a: GO:0050937 ! regulation of iridophore differentiation is_a: GO:0050941 ! negative regulation of pigment cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0050935 ! negatively regulates iridophore differentiation relationship: RO:0002212 GO:0050935 ! negatively regulates iridophore differentiation [Term] id: GO:0050944 name: negative regulation of xanthophore differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of xanthophore differentiation." [GOC:ai] comment: Note that this term refers to xanthophores in the sense of specialized pigment-producing cells, and should not be confused with the cellular component term 'xanthophore ; GO:0031633', which refers to a subcellular structure. synonym: "down regulation of xanthophore differentiation" EXACT [] synonym: "down-regulation of xanthophore differentiation" EXACT [] synonym: "downregulation of xanthophore differentiation" EXACT [] synonym: "inhibition of xanthophore differentiation" NARROW [] is_a: GO:0050938 ! regulation of xanthophore differentiation is_a: GO:0050941 ! negative regulation of pigment cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0050936 ! negatively regulates xanthophore differentiation relationship: RO:0002212 GO:0050936 ! negatively regulates xanthophore differentiation [Term] id: GO:0050945 name: positive regulation of iridophore differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of iridophore differentiation." [GOC:ai] synonym: "activation of iridophore differentiation" NARROW [] synonym: "stimulation of iridophore differentiation" NARROW [] synonym: "up regulation of iridophore differentiation" EXACT [] synonym: "up-regulation of iridophore differentiation" EXACT [] synonym: "upregulation of iridophore differentiation" EXACT [] is_a: GO:0050937 ! regulation of iridophore differentiation is_a: GO:0050942 ! positive regulation of pigment cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0050935 ! positively regulates iridophore differentiation relationship: RO:0002213 GO:0050935 ! positively regulates iridophore differentiation [Term] id: GO:0050946 name: positive regulation of xanthophore differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of xanthophore differentiation." [GOC:ai] comment: Note that this term refers to xanthophores in the sense of specialized pigment-producing cells, and should not be confused with the cellular component term 'xanthophore ; GO:0031633', which refers to a subcellular structure. synonym: "activation of xanthophore differentiation" NARROW [] synonym: "stimulation of xanthophore differentiation" NARROW [] synonym: "up regulation of xanthophore differentiation" EXACT [] synonym: "up-regulation of xanthophore differentiation" EXACT [] synonym: "upregulation of xanthophore differentiation" EXACT [] is_a: GO:0050938 ! regulation of xanthophore differentiation is_a: GO:0050942 ! positive regulation of pigment cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0050936 ! positively regulates xanthophore differentiation relationship: RO:0002213 GO:0050936 ! positively regulates xanthophore differentiation [Term] id: GO:0050951 name: sensory perception of temperature stimulus namespace: biological_process def: "The series of events required for an organism to receive a sensory temperature stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process." [GOC:ai] synonym: "sensory perception of thermal stimulus" EXACT [] is_a: GO:0007600 ! sensory perception [Term] id: GO:0050952 name: sensory perception of electrical stimulus namespace: biological_process def: "The series of events required for an organism to receive a sensory electrical stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process." [GOC:ai] is_a: GO:0007600 ! sensory perception [Term] id: GO:0050953 name: sensory perception of light stimulus namespace: biological_process def: "The series of events required for an organism to receive a sensory light stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process." [GOC:ai] is_a: GO:0007600 ! sensory perception [Term] id: GO:0050954 name: sensory perception of mechanical stimulus namespace: biological_process def: "The series of events required for an organism to receive a sensory mechanical stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process." [GOC:ai] synonym: "chemi-mechanical coupling" RELATED [] synonym: "mechanosensory perception" EXACT [] synonym: "perception of mechanical stimulus" EXACT [] is_a: GO:0007600 ! sensory perception [Term] id: GO:0050955 name: thermoception namespace: biological_process def: "The series of events required for an organism to receive a temperature stimulus, convert it to a molecular signal, and recognize and characterize the signal. Thermoception in larger animals is mainly done in the skin; mammals have at least two types of sensor, for detecting heat (temperatures above body temperature) and cold (temperatures below body temperature)." [GOC:ai, Wikipedia:Thermoception] synonym: "thermoreception" EXACT [] xref: Wikipedia:Thermoception is_a: GO:0050951 ! sensory perception of temperature stimulus [Term] id: GO:0050956 name: electroception namespace: biological_process def: "The series of events required for an organism to receive an electrical stimulus, convert it to a molecular signal, and recognize and characterize the signal. Many fish possess an electroception sense; for example, the electric eel uses low voltage pulses of electricity for navigation and prey location." [GOC:ai, PMID:10210663, Wikipedia:Electroreception] synonym: "electroception sense" EXACT [] synonym: "electroceptive sense" EXACT [] xref: Wikipedia:Electroreception is_a: GO:0050952 ! sensory perception of electrical stimulus [Term] id: GO:0050957 name: equilibrioception namespace: biological_process def: "The series of events required for an organism to receive an orientational stimulus, convert it to a molecular signal, and recognize and characterize the signal. Equilibrioception refers to a combination of processes by which an organism can perceive its orientation with respect to gravity. In animals, stimuli come from labyrinth system of the inner ears, monitoring the direction of motion; visual stimuli, with information on orientation and motion; pressure receptors, which tell the organism which body surfaces are in contact with the ground; and proprioceptive cues, which report which parts of the body are in motion." [PMID:29303967] synonym: "sensory perception of orientation with respect to gravity" EXACT [] xref: Wikipedia:Equilibrioception is_a: GO:0007600 ! sensory perception relationship: BFO:0000050 GO:0050885 ! part of neuromuscular process controlling balance [Term] id: GO:0050960 name: detection of temperature stimulus involved in thermoception namespace: biological_process def: "The series of events in which a temperature stimulus is received and converted into a molecular signal as part of thermoception." [GOC:ai, GOC:dos] synonym: "sensory detection of temperature stimulus during thermoception" EXACT [] synonym: "sensory detection of thermal stimulus during thermoception" EXACT [] synonym: "sensory transduction of temperature stimulus during thermoception" EXACT [] synonym: "sensory transduction of thermal stimulus during thermoception" EXACT [] synonym: "thermoception, sensory detection of temperature stimulus" EXACT [] synonym: "thermoception, sensory detection of thermal stimulus" EXACT [] synonym: "thermoception, sensory transduction of temperature stimulus" EXACT [] synonym: "thermoception, sensory transduction of thermal stimulus" EXACT [] is_a: GO:0050961 ! detection of temperature stimulus involved in sensory perception intersection_of: GO:0016048 ! detection of temperature stimulus intersection_of: BFO:0000050 GO:0050955 ! part of thermoception relationship: BFO:0000050 GO:0050955 ! part of thermoception [Term] id: GO:0050961 name: detection of temperature stimulus involved in sensory perception namespace: biological_process def: "The series of events in which a temperature stimulus is received and converted into a molecular signal as part of sensory perception." [GOC:ai, GOC:dos] synonym: "sensory detection of heat stimulus during sensory perception" NARROW [] synonym: "sensory detection of temperature stimulus" EXACT [] synonym: "sensory detection of temperature stimulus during sensory perception" EXACT [] synonym: "sensory detection of thermal stimulus during sensory perception" EXACT [] synonym: "sensory perception, sensory detection of heat stimulus" NARROW [] synonym: "sensory perception, sensory detection of temperature stimulus" EXACT [] synonym: "sensory perception, sensory detection of thermal stimulus" EXACT [] synonym: "sensory perception, sensory transduction of heat stimulus" NARROW [] synonym: "sensory perception, sensory transduction of temperature stimulus" EXACT [] synonym: "sensory perception, sensory transduction of thermal stimulus" EXACT [] synonym: "sensory transduction of heat stimulus during sensory perception" NARROW [] synonym: "sensory transduction of temperature stimulus" EXACT [] synonym: "sensory transduction of temperature stimulus during sensory perception" EXACT [] synonym: "sensory transduction of thermal stimulus during sensory perception" EXACT [] is_a: GO:0016048 ! detection of temperature stimulus is_a: GO:0050906 ! detection of stimulus involved in sensory perception intersection_of: GO:0016048 ! detection of temperature stimulus intersection_of: BFO:0000050 GO:0007600 ! part of sensory perception relationship: BFO:0000050 GO:0050951 ! part of sensory perception of temperature stimulus [Term] id: GO:0050962 name: detection of light stimulus involved in sensory perception namespace: biological_process def: "The series of events in which a light stimulus is received by a cell and converted into a molecular signal as part of the sensory perception of light." [GOC:ai, GOC:dos] synonym: "sensory detection of light stimulus" EXACT [] synonym: "sensory detection of light stimulus during sensory perception" EXACT [] synonym: "sensory perception, sensory detection of light stimulus" EXACT [] synonym: "sensory perception, sensory transduction of light stimulus" EXACT [] synonym: "sensory transduction of light stimulus" EXACT [] synonym: "sensory transduction of light stimulus during sensory perception" EXACT [] is_a: GO:0009583 ! detection of light stimulus is_a: GO:0050906 ! detection of stimulus involved in sensory perception intersection_of: GO:0009583 ! detection of light stimulus intersection_of: BFO:0000050 GO:0007600 ! part of sensory perception relationship: BFO:0000050 GO:0050953 ! part of sensory perception of light stimulus [Term] id: GO:0050963 name: detection of electrical stimulus involved in sensory perception namespace: biological_process def: "The series of events in which an electrical stimulus is received by a cell and converted into a molecular signal as part of sensory perception." [GOC:ai, GOC:dos] synonym: "sensory detection of electrical stimulus" EXACT [] synonym: "sensory detection of electrical stimulus during sensory perception" EXACT [] synonym: "sensory perception, sensory detection of electrical stimulus" EXACT [] synonym: "sensory perception, sensory transduction of electrical stimulus" EXACT [] synonym: "sensory transduction of electrical stimulus" EXACT [] synonym: "sensory transduction of electrical stimulus during sensory perception" EXACT [] is_a: GO:0050906 ! detection of stimulus involved in sensory perception is_a: GO:0050981 ! detection of electrical stimulus intersection_of: GO:0050981 ! detection of electrical stimulus intersection_of: BFO:0000050 GO:0007600 ! part of sensory perception relationship: BFO:0000050 GO:0050952 ! part of sensory perception of electrical stimulus [Term] id: GO:0050964 name: detection of electrical stimulus involved in electroception namespace: biological_process def: "The series of events that contribute to electroception in which an electrical stimulus is received and converted into a molecular signal." [GOC:ai, GOC:dos] synonym: "detection of electrical stimulus during electroreception" RELATED [GOC:dph, GOC:tb] synonym: "electroception, detection of electrical stimulus" EXACT [] synonym: "electroception, sensory detection of electrical stimulus" EXACT [] synonym: "electroception, sensory transduction" EXACT [] synonym: "electroception, sensory transduction of electrical stimulus" EXACT [] synonym: "sensory detection of electrical stimulus during electroception" RELATED [] synonym: "sensory transduction of electrical stimulus during electroception" RELATED [] is_a: GO:0050963 ! detection of electrical stimulus involved in sensory perception intersection_of: GO:0050981 ! detection of electrical stimulus intersection_of: BFO:0000050 GO:0050956 ! part of electroception relationship: BFO:0000050 GO:0050956 ! part of electroception [Term] id: GO:0050965 name: detection of temperature stimulus involved in sensory perception of pain namespace: biological_process def: "The series of events involved in the perception of pain in which a temperature stimulus is received and converted into a molecular signal." [GOC:ai, GOC:dos] synonym: "perception of pain, detection of temperature stimulus" EXACT [] synonym: "perception of pain, sensory detection of temperature stimulus" EXACT [] synonym: "perception of pain, sensory transduction of temperature stimulus" EXACT [] synonym: "sensory detection of temperature stimulus during perception of pain" EXACT [] synonym: "sensory detection of thermal stimulus during sensory perception of pain" EXACT [] synonym: "sensory perception of pain, sensory detection of thermal stimulus" EXACT [] synonym: "sensory perception of pain, sensory transduction of thermal stimulus" EXACT [] synonym: "sensory transduction of temperature stimulus during perception of pain" EXACT [] synonym: "sensory transduction of thermal stimulus during sensory perception of pain" EXACT [] synonym: "thermal nociception" RELATED [GOC:pr] is_a: GO:0050961 ! detection of temperature stimulus involved in sensory perception is_a: GO:0062149 ! detection of stimulus involved in sensory perception of pain intersection_of: GO:0016048 ! detection of temperature stimulus intersection_of: BFO:0000050 GO:0019233 ! part of sensory perception of pain [Term] id: GO:0050966 name: detection of mechanical stimulus involved in sensory perception of pain namespace: biological_process def: "The series of events involved in the perception of pain in which a mechanical stimulus is received and converted into a molecular signal." [GOC:ai, GOC:dos] synonym: "mechanical nociception" RELATED [GOC:pr] synonym: "perception of pain, detection of mechanical stimulus" EXACT [] synonym: "perception of pain, sensory detection of mechanical stimulus" EXACT [] synonym: "perception of pain, sensory transduction of mechanical stimulus" EXACT [] synonym: "sensory detection of mechanical stimulus during perception of pain" EXACT [] synonym: "sensory transduction of mechanical stimulus during perception of pain" EXACT [] is_a: GO:0050974 ! detection of mechanical stimulus involved in sensory perception is_a: GO:0062149 ! detection of stimulus involved in sensory perception of pain intersection_of: GO:0050982 ! detection of mechanical stimulus intersection_of: BFO:0000050 GO:0019233 ! part of sensory perception of pain [Term] id: GO:0050967 name: detection of electrical stimulus involved in sensory perception of pain namespace: biological_process def: "The series of events that contribute to the perception of pain in which an electrical stimulus is received and converted into a molecular signal." [GOC:ai, GOC:dos, GOC:dph, GOC:tb] synonym: "detection of electrical stimulus during sensory perception of pain" RELATED [GOC:dph, GOC:tb] synonym: "perception of pain, detection of electrical stimulus" EXACT [] synonym: "perception of pain, sensory detection of electrical stimulus" EXACT [] synonym: "perception of pain, sensory transduction of electrical stimulus" EXACT [] synonym: "sensory detection of electrical stimulus during perception of pain" RELATED [] synonym: "sensory transduction of electrical stimulus during perception of pain" RELATED [] is_a: GO:0050963 ! detection of electrical stimulus involved in sensory perception is_a: GO:0062149 ! detection of stimulus involved in sensory perception of pain intersection_of: GO:0050981 ! detection of electrical stimulus intersection_of: BFO:0000050 GO:0019233 ! part of sensory perception of pain [Term] id: GO:0050968 name: detection of chemical stimulus involved in sensory perception of pain namespace: biological_process def: "The series of events involved in the perception of pain in which a chemical stimulus is received and converted into a molecular signal." [GOC:ai] synonym: "chemical nociception" RELATED [GOC:pr] synonym: "perception of pain, detection of chemical stimulus" EXACT [] synonym: "perception of pain, sensory detection of chemical stimulus" EXACT [] synonym: "perception of pain, sensory transduction of chemical stimulus" EXACT [] synonym: "sensory detection of chemical stimulus during perception of pain" EXACT [] synonym: "sensory transduction of chemical stimulus during perception of pain" EXACT [] is_a: GO:0050907 ! detection of chemical stimulus involved in sensory perception is_a: GO:0062149 ! detection of stimulus involved in sensory perception of pain intersection_of: GO:0009593 ! detection of chemical stimulus intersection_of: BFO:0000050 GO:0019233 ! part of sensory perception of pain [Term] id: GO:0050973 name: detection of mechanical stimulus involved in equilibrioception namespace: biological_process def: "The series of events involved in equilibrioception in which a mechanical stimulus is received and converted into a molecular signal. During equilibrioception, mechanical stimuli may be in the form of input from pressure receptors or from the labyrinth system of the inner ears." [GOC:ai, GOC:dos] synonym: "equilibrioception, detection of mechanical stimulus" EXACT [] synonym: "equilibrioception, sensory detection of mechanical stimulus" EXACT [] synonym: "equilibrioception, sensory transduction of mechanical stimulus" EXACT [] synonym: "sensory detection of mechanical stimulus during equilibrioception" EXACT [] synonym: "sensory transduction of mechanical stimulus during equilibrioception" EXACT [] is_a: GO:0050974 ! detection of mechanical stimulus involved in sensory perception intersection_of: GO:0050982 ! detection of mechanical stimulus intersection_of: BFO:0000050 GO:0050957 ! part of equilibrioception relationship: BFO:0000050 GO:0050957 ! part of equilibrioception [Term] id: GO:0050974 name: detection of mechanical stimulus involved in sensory perception namespace: biological_process def: "The series of events in which a mechanical stimulus is received and converted into a molecular signal as part of sensory perception." [GOC:ai, GOC:dos] synonym: "sensory detection of mechanical stimulus" EXACT [] synonym: "sensory detection of mechanical stimulus during sensory perception" EXACT [] synonym: "sensory perception, sensory detection of mechanical stimulus" EXACT [] synonym: "sensory perception, sensory transduction of mechanical stimulus" EXACT [] synonym: "sensory transduction of mechanical stimulus" EXACT [] synonym: "sensory transduction of mechanical stimulus during sensory perception" EXACT [] is_a: GO:0050906 ! detection of stimulus involved in sensory perception is_a: GO:0050982 ! detection of mechanical stimulus intersection_of: GO:0050982 ! detection of mechanical stimulus intersection_of: BFO:0000050 GO:0007600 ! part of sensory perception relationship: BFO:0000050 GO:0050954 ! part of sensory perception of mechanical stimulus [Term] id: GO:0050975 name: sensory perception of touch namespace: biological_process def: "The series of events required for an organism to receive a touch stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process. The perception of touch in animals is mediated by mechanoreceptors in the skin and mucous membranes and is the sense by which contact with objects gives evidence as to certain of their qualities. Different types of touch can be perceived (for example, light, coarse, pressure and tickling) and the stimulus may be external or internal (e.g. the feeling of a full stomach)." [GOC:ai] synonym: "perception of touch" EXACT [] synonym: "tactile sense" EXACT [] synonym: "taction" EXACT [] synonym: "tactition" EXACT [] xref: Wikipedia:Touch is_a: GO:0050954 ! sensory perception of mechanical stimulus [Term] id: GO:0050976 name: detection of mechanical stimulus involved in sensory perception of touch namespace: biological_process def: "The series of events involved in the perception of touch in which a mechanical stimulus is received and converted into a molecular signal." [GOC:ai, GOC:dos] synonym: "perception of touch, detection of mechanical stimulus" EXACT [] synonym: "perception of touch, sensory detection of mechanical stimulus" EXACT [] synonym: "perception of touch, sensory transduction of mechanical stimulus" EXACT [] synonym: "sensory detection of mechanical stimulus during perception of touch" EXACT [] synonym: "sensory transduction of mechanical stimulus during perception of touch" EXACT [] synonym: "tactition, sensory detection of mechanical stimulus" EXACT [] is_a: GO:0050974 ! detection of mechanical stimulus involved in sensory perception intersection_of: GO:0050982 ! detection of mechanical stimulus intersection_of: BFO:0000050 GO:0050975 ! part of sensory perception of touch relationship: BFO:0000050 GO:0050975 ! part of sensory perception of touch [Term] id: GO:0050981 name: detection of electrical stimulus namespace: biological_process def: "The series of events by which an electrical stimulus is received and converted into a molecular signal." [GOC:ai, GOC:dos] is_a: GO:0009582 ! detection of abiotic stimulus is_a: GO:0051602 ! response to electrical stimulus [Term] id: GO:0050982 name: detection of mechanical stimulus namespace: biological_process def: "The series of events by which a mechanical stimulus is received and converted into a molecular signal." [GOC:ai, GOC:dos] is_a: GO:0009581 ! detection of external stimulus is_a: GO:0009582 ! detection of abiotic stimulus is_a: GO:0009612 ! response to mechanical stimulus [Term] id: GO:0050994 name: regulation of lipid catabolic process namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of lipids." [GOC:ai] synonym: "regulation of lipid breakdown" EXACT [] synonym: "regulation of lipid catabolism" EXACT [] synonym: "regulation of lipid degradation" EXACT [] is_a: GO:0009894 ! regulation of catabolic process is_a: GO:0019216 ! regulation of lipid metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0016042 ! regulates lipid catabolic process relationship: RO:0002211 GO:0016042 ! regulates lipid catabolic process [Term] id: GO:0050995 name: negative regulation of lipid catabolic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of lipids." [GOC:ai] synonym: "down regulation of lipid catabolic process" EXACT [] synonym: "down-regulation of lipid catabolic process" EXACT [] synonym: "downregulation of lipid catabolic process" EXACT [] synonym: "inhibition of lipid catabolic process" NARROW [] synonym: "negative regulation of lipid breakdown" EXACT [] synonym: "negative regulation of lipid catabolism" EXACT [] synonym: "negative regulation of lipid degradation" EXACT [] is_a: GO:0009895 ! negative regulation of catabolic process is_a: GO:0045833 ! negative regulation of lipid metabolic process is_a: GO:0050994 ! regulation of lipid catabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0016042 ! negatively regulates lipid catabolic process relationship: RO:0002212 GO:0016042 ! negatively regulates lipid catabolic process [Term] id: GO:0050996 name: positive regulation of lipid catabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of lipids." [GOC:ai] synonym: "activation of lipid catabolic process" NARROW [] synonym: "positive regulation of lipid breakdown" EXACT [] synonym: "positive regulation of lipid catabolism" EXACT [] synonym: "positive regulation of lipid degradation" EXACT [] synonym: "stimulation of lipid catabolic process" NARROW [] synonym: "up regulation of lipid catabolic process" EXACT [] synonym: "up-regulation of lipid catabolic process" EXACT [] synonym: "upregulation of lipid catabolic process" EXACT [] is_a: GO:0009896 ! positive regulation of catabolic process is_a: GO:0045834 ! positive regulation of lipid metabolic process is_a: GO:0050994 ! regulation of lipid catabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0016042 ! positively regulates lipid catabolic process relationship: RO:0002213 GO:0016042 ! positively regulates lipid catabolic process [Term] id: GO:0051017 name: actin filament bundle assembly namespace: biological_process def: "The assembly of actin filament bundles; actin filaments are on the same axis but may be oriented with the same or opposite polarities and may be packed with different levels of tightness." [GOC:ai] synonym: "actin bundling activity" RELATED [] synonym: "actin cable assembly" RELATED [GOC:mah] synonym: "actin cable formation" RELATED [GOC:mah] is_a: GO:0022607 ! cellular component assembly is_a: GO:0061572 ! actin filament bundle organization intersection_of: GO:0022607 ! cellular component assembly intersection_of: RO:0002588 GO:0032432 ! results in assembly of actin filament bundle relationship: RO:0002588 GO:0032432 ! results in assembly of actin filament bundle [Term] id: GO:0051027 name: DNA transport namespace: biological_process def: "The directed movement of RNA, deoxyribonucleic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] is_a: GO:0050657 ! nucleic acid transport intersection_of: GO:0006810 ! transport intersection_of: RO:0004009 CHEBI:16991 ! has primary input relationship: RO:0004009 CHEBI:16991 ! has primary input [Term] id: GO:0051031 name: tRNA transport namespace: biological_process def: "The directed movement of tRNA, transfer ribonucleic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] is_a: GO:0050658 ! RNA transport intersection_of: GO:0006810 ! transport intersection_of: RO:0004009 CHEBI:17843 ! has primary input relationship: RO:0004009 CHEBI:17843 ! has primary input [Term] id: GO:0051032 name: nucleic acid transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of nucleic acids from one side of a membrane to the other. Nucleic acids are single or double-stranded polynucleotides involved in the storage, transmission and transfer of genetic information." [GOC:ai] is_a: GO:0015932 ! nucleobase-containing compound transmembrane transporter activity is_a: GO:0022884 ! macromolecule transmembrane transporter activity intersection_of: GO:0022857 ! transmembrane transporter activity intersection_of: RO:0004009 CHEBI:33696 ! has primary input relationship: BFO:0000050 GO:0050657 ! part of nucleic acid transport relationship: RO:0004009 CHEBI:33696 ! has primary input [Term] id: GO:0051033 name: RNA transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of RNA, ribonucleic acid, from one side of a membrane to the other." [GOC:ai] xref: Reactome:R-HSA-203906 "Exportin complex translocates pre-miRNA to cytosol" is_a: GO:0051032 ! nucleic acid transmembrane transporter activity intersection_of: GO:0022857 ! transmembrane transporter activity intersection_of: RO:0004009 CHEBI:33697 ! has primary input relationship: BFO:0000050 GO:0050658 ! part of RNA transport relationship: RO:0004009 CHEBI:33697 ! has primary input [Term] id: GO:0051034 name: tRNA transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of tRNA, transfer ribonucleic acid, from one side of a membrane to the other." [GOC:ai] is_a: GO:0051033 ! RNA transmembrane transporter activity intersection_of: GO:0022857 ! transmembrane transporter activity intersection_of: RO:0004009 CHEBI:17843 ! has primary input relationship: BFO:0000050 GO:0051031 ! part of tRNA transport relationship: RO:0004009 CHEBI:17843 ! has primary input [Term] id: GO:0051035 name: DNA transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of DNA, deoxyribonucleic acid, from one side of a membrane to the other." [GOC:ai] is_a: GO:0051032 ! nucleic acid transmembrane transporter activity intersection_of: GO:0022857 ! transmembrane transporter activity intersection_of: RO:0004009 CHEBI:16991 ! has primary input relationship: BFO:0000050 GO:0051027 ! part of DNA transport relationship: RO:0004009 CHEBI:16991 ! has primary input [Term] id: GO:0051046 name: regulation of secretion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the controlled release of a substance from a cell or a tissue." [GOC:ai] is_a: GO:0051049 ! regulation of transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0046903 ! regulates secretion relationship: RO:0002211 GO:0046903 ! regulates secretion [Term] id: GO:0051047 name: positive regulation of secretion namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the controlled release of a substance from a cell or a tissue." [GOC:ai] synonym: "activation of secretion" NARROW [] synonym: "stimulation of secretion" NARROW [] synonym: "up regulation of secretion" EXACT [] synonym: "up-regulation of secretion" EXACT [] synonym: "upregulation of secretion" EXACT [] is_a: GO:0051046 ! regulation of secretion is_a: GO:0051050 ! positive regulation of transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0046903 ! positively regulates secretion relationship: RO:0002213 GO:0046903 ! positively regulates secretion [Term] id: GO:0051048 name: negative regulation of secretion namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the controlled release of a substance from a cell or a tissue." [GOC:ai] synonym: "down regulation of secretion" EXACT [] synonym: "down-regulation of secretion" EXACT [] synonym: "downregulation of secretion" EXACT [] synonym: "inhibition of secretion" NARROW [] is_a: GO:0051046 ! regulation of secretion is_a: GO:0051051 ! negative regulation of transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0046903 ! negatively regulates secretion relationship: RO:0002212 GO:0046903 ! negatively regulates secretion [Term] id: GO:0051049 name: regulation of transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] subset: goslim_yeast is_a: GO:0032879 ! regulation of localization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0006810 ! regulates transport relationship: RO:0002211 GO:0006810 ! regulates transport [Term] id: GO:0051050 name: positive regulation of transport namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] synonym: "activation of transport" NARROW [] synonym: "stimulation of transport" NARROW [] synonym: "up regulation of transport" EXACT [] synonym: "up-regulation of transport" EXACT [] synonym: "upregulation of transport" EXACT [] is_a: GO:0048518 ! positive regulation of biological process is_a: GO:0051049 ! regulation of transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0006810 ! positively regulates transport relationship: RO:0002213 GO:0006810 ! positively regulates transport [Term] id: GO:0051051 name: negative regulation of transport namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] synonym: "down regulation of transport" EXACT [] synonym: "down-regulation of transport" EXACT [] synonym: "downregulation of transport" EXACT [] synonym: "inhibition of transport" NARROW [] is_a: GO:0048519 ! negative regulation of biological process is_a: GO:0051049 ! regulation of transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0006810 ! negatively regulates transport relationship: RO:0002212 GO:0006810 ! negatively regulates transport [Term] id: GO:0051052 name: regulation of DNA metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving DNA." [GOC:ai] subset: goslim_yeast synonym: "regulation of DNA metabolism" EXACT [] is_a: GO:0019219 ! regulation of nucleobase-containing compound metabolic process is_a: GO:0060255 ! regulation of macromolecule metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0006259 ! regulates DNA metabolic process relationship: RO:0002211 GO:0006259 ! regulates DNA metabolic process [Term] id: GO:0051053 name: negative regulation of DNA metabolic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving DNA." [GOC:ai] synonym: "down regulation of DNA metabolic process" EXACT [] synonym: "down-regulation of DNA metabolic process" EXACT [] synonym: "downregulation of DNA metabolic process" EXACT [] synonym: "inhibition of DNA metabolic process" NARROW [] synonym: "negative regulation of DNA metabolism" EXACT [] is_a: GO:0010605 ! negative regulation of macromolecule metabolic process is_a: GO:0045934 ! negative regulation of nucleobase-containing compound metabolic process is_a: GO:0051052 ! regulation of DNA metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0006259 ! negatively regulates DNA metabolic process relationship: RO:0002212 GO:0006259 ! negatively regulates DNA metabolic process [Term] id: GO:0051054 name: positive regulation of DNA metabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving DNA." [GOC:ai] synonym: "activation of DNA metabolic process" NARROW [] synonym: "positive regulation of DNA metabolism" EXACT [] synonym: "stimulation of DNA metabolic process" NARROW [] synonym: "up regulation of DNA metabolic process" EXACT [] synonym: "up-regulation of DNA metabolic process" EXACT [] synonym: "upregulation of DNA metabolic process" EXACT [] is_a: GO:0010604 ! positive regulation of macromolecule metabolic process is_a: GO:0051052 ! regulation of DNA metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0006259 ! positively regulates DNA metabolic process relationship: RO:0002213 GO:0006259 ! positively regulates DNA metabolic process [Term] id: GO:0051055 name: negative regulation of lipid biosynthetic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of lipids." [GOC:ai] synonym: "down regulation of lipid biosynthetic process" EXACT [] synonym: "down-regulation of lipid biosynthetic process" EXACT [] synonym: "downregulation of lipid biosynthetic process" EXACT [] synonym: "inhibition of lipid biosynthetic process" NARROW [] synonym: "negative regulation of lipid anabolism" EXACT [] synonym: "negative regulation of lipid biosynthesis" EXACT [] synonym: "negative regulation of lipid formation" EXACT [] synonym: "negative regulation of lipid synthesis" EXACT [] synonym: "negative regulation of lipogenesis" EXACT [GOC:sl] is_a: GO:0009890 ! negative regulation of biosynthetic process is_a: GO:0045833 ! negative regulation of lipid metabolic process is_a: GO:0046890 ! regulation of lipid biosynthetic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0008610 ! negatively regulates lipid biosynthetic process relationship: RO:0002212 GO:0008610 ! negatively regulates lipid biosynthetic process [Term] id: GO:0051059 name: NF-kappaB binding namespace: molecular_function def: "Binding to NF-kappaB, a transcription factor for eukaryotic RNA polymerase II promoters." [GOC:ai] is_a: GO:0061629 ! RNA polymerase II-specific DNA-binding transcription factor binding intersection_of: GO:0005488 ! binding intersection_of: RO:0004009 PR:000001753 ! has primary input transcription factor NF-kappa-B subunit relationship: RO:0004009 PR:000001753 ! has primary input transcription factor NF-kappa-B subunit [Term] id: GO:0051078 name: meiotic nuclear membrane disassembly namespace: biological_process def: "The cell cycle process in which the controlled breakdown of the nuclear membranes during meiotic cell division occurs." [GOC:bf] synonym: "meiotic nuclear envelope breakdown" RELATED [] synonym: "meiotic nuclear envelope catabolism" RELATED [] synonym: "meiotic nuclear envelope degradation" RELATED [] synonym: "meiotic nuclear envelope disassembly" RELATED [] is_a: GO:0051081 ! nuclear membrane disassembly is_a: GO:1903046 ! meiotic cell cycle process intersection_of: GO:0051081 ! nuclear membrane disassembly intersection_of: BFO:0000050 GO:0051321 ! part of meiotic cell cycle [Term] id: GO:0051080 name: meiosis II nuclear membrane disassembly namespace: biological_process def: "The controlled breakdown of the nuclear membranes during the second division of meiosis." [GOC:bf] synonym: "meiosis II nuclear envelope breakdown" RELATED [] synonym: "meiosis II nuclear envelope catabolism" RELATED [] synonym: "meiosis II nuclear envelope degradation" RELATED [] synonym: "meiosis II nuclear envelope disassembly" RELATED [] is_a: GO:0051078 ! meiotic nuclear membrane disassembly intersection_of: GO:0051081 ! nuclear membrane disassembly intersection_of: BFO:0000050 GO:0007135 ! part of meiosis II relationship: BFO:0000050 GO:0007135 ! part of meiosis II [Term] id: GO:0051081 name: nuclear membrane disassembly namespace: biological_process def: "The controlled breakdown of the nuclear membranes, for example during cellular division." [GOC:ai] synonym: "nuclear envelope breakdown" RELATED [] synonym: "nuclear envelope catabolism" RELATED [] synonym: "nuclear envelope degradation" RELATED [] synonym: "nuclear envelope disassembly" RELATED [] is_a: GO:0030397 ! membrane disassembly is_a: GO:0071763 ! nuclear membrane organization intersection_of: GO:0022411 ! cellular component disassembly intersection_of: RO:0002590 GO:0031965 ! results in disassembly of nuclear membrane relationship: RO:0002590 GO:0031965 ! results in disassembly of nuclear membrane [Term] id: GO:0051093 name: negative regulation of developmental process namespace: biological_process def: "Any process that stops, prevents or reduces the rate or extent of development, the biological process whose specific outcome is the progression of an organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:ai] synonym: "down regulation of developmental process" EXACT [] synonym: "down-regulation of developmental process" EXACT [] synonym: "downregulation of developmental process" EXACT [] synonym: "inhibition of developmental process" NARROW [] is_a: GO:0048519 ! negative regulation of biological process is_a: GO:0050793 ! regulation of developmental process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0032502 ! negatively regulates developmental process relationship: RO:0002212 GO:0032502 ! negatively regulates developmental process [Term] id: GO:0051094 name: positive regulation of developmental process namespace: biological_process def: "Any process that activates or increases the rate or extent of development, the biological process whose specific outcome is the progression of an organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:ai] synonym: "activation of developmental process" NARROW [] synonym: "stimulation of developmental process" NARROW [] synonym: "up regulation of developmental process" EXACT [] synonym: "up-regulation of developmental process" EXACT [] synonym: "upregulation of developmental process" EXACT [] is_a: GO:0048518 ! positive regulation of biological process is_a: GO:0050793 ! regulation of developmental process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0032502 ! positively regulates developmental process relationship: RO:0002213 GO:0032502 ! positively regulates developmental process [Term] id: GO:0051098 name: regulation of binding namespace: biological_process def: "Any process that modulates the frequency, rate or extent of binding, the selective interaction of a molecule with one or more specific sites on another molecule." [GOC:ai] subset: gocheck_do_not_annotate is_a: GO:0065009 ! regulation of molecular function intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0005488 ! regulates binding relationship: RO:0002211 GO:0005488 ! regulates binding [Term] id: GO:0051099 name: positive regulation of binding namespace: biological_process def: "Any process that activates or increases the rate or extent of binding, the selective interaction of a molecule with one or more specific sites on another molecule." [GOC:ai] subset: gocheck_do_not_annotate synonym: "activation of binding" NARROW [] synonym: "stimulation of binding" NARROW [] synonym: "up regulation of binding" EXACT [] synonym: "up-regulation of binding" EXACT [] synonym: "upregulation of binding" EXACT [] is_a: GO:0044093 ! positive regulation of molecular function is_a: GO:0051098 ! regulation of binding intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0005488 ! positively regulates binding relationship: RO:0002213 GO:0005488 ! positively regulates binding [Term] id: GO:0051100 name: negative regulation of binding namespace: biological_process def: "Any process that stops or reduces the rate or extent of binding, the selective interaction of a molecule with one or more specific sites on another molecule." [GOC:ai] subset: gocheck_do_not_annotate synonym: "down regulation of binding" EXACT [] synonym: "down-regulation of binding" EXACT [] synonym: "downregulation of binding" EXACT [] synonym: "inhibition of binding" NARROW [] is_a: GO:0044092 ! negative regulation of molecular function is_a: GO:0051098 ! regulation of binding intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0005488 ! negatively regulates binding relationship: RO:0002212 GO:0005488 ! negatively regulates binding [Term] id: GO:0051101 name: regulation of DNA binding namespace: biological_process def: "Any process that modulates the frequency, rate or extent of DNA binding. DNA binding is any process in which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:ai, GOC:dph, GOC:tb] subset: gocheck_do_not_annotate is_a: GO:0051098 ! regulation of binding intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0003677 ! regulates DNA binding relationship: RO:0002211 GO:0003677 ! regulates DNA binding [Term] id: GO:0051119 name: sugar transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of a sugar from one side of a membrane to the other. A sugar is any member of a class of sweet, water-soluble, crystallizable carbohydrates, which are the monosaccharides and smaller oligosaccharides." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] synonym: "sugar/polyol channel activity" NARROW [] xref: Reactome:R-HSA-428779 "GLUT7 and GLUT11 transport glucose and fructose" xref: Reactome:R-HSA-8875902 "SLC45A3 transports Glc from extracellular region to cytosol" xref: Reactome:R-HSA-8876319 "SLC50A1 transports Glc from cytosol to extracellular region" is_a: GO:0015144 ! carbohydrate transmembrane transporter activity [Term] id: GO:0051128 name: regulation of cellular component organization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell structures, including the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope." [GOC:ai] subset: gocheck_do_not_annotate synonym: "regulation of cell organisation" RELATED [GOC:mah] synonym: "regulation of cell organization" RELATED [GOC:mah] synonym: "regulation of cellular component organisation" EXACT [] synonym: "regulation of cellular component organization and biogenesis" RELATED [GOC:mah] is_a: GO:0050794 ! regulation of cellular process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0016043 ! regulates cellular component organization relationship: RO:0002211 GO:0016043 ! regulates cellular component organization [Term] id: GO:0051129 name: negative regulation of cellular component organization namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell structures, including the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope." [GOC:ai] synonym: "down regulation of cell organization" EXACT [] synonym: "down-regulation of cell organization" EXACT [] synonym: "downregulation of cell organization" EXACT [] synonym: "inhibition of cell organization" NARROW [] synonym: "negative regulation of cell organisation" RELATED [GOC:mah] synonym: "negative regulation of cellular component organization and biogenesis" RELATED [GOC:mah] is_a: GO:0048523 ! negative regulation of cellular process is_a: GO:0051128 ! regulation of cellular component organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0016043 ! negatively regulates cellular component organization relationship: RO:0002212 GO:0016043 ! negatively regulates cellular component organization [Term] id: GO:0051130 name: positive regulation of cellular component organization namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell structures, including the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope." [GOC:ai] synonym: "activation of cell organization" NARROW [] synonym: "positive regulation of cell organisation" EXACT [] synonym: "positive regulation of cellular component organization and biogenesis" RELATED [GOC:mah] synonym: "stimulation of cell organization" NARROW [] synonym: "up regulation of cell organization" EXACT [] synonym: "up-regulation of cell organization" EXACT [] synonym: "upregulation of cell organization" EXACT [] is_a: GO:0048522 ! positive regulation of cellular process is_a: GO:0051128 ! regulation of cellular component organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0016043 ! positively regulates cellular component organization relationship: RO:0002213 GO:0016043 ! positively regulates cellular component organization [Term] id: GO:0051132 name: NK T cell activation namespace: biological_process def: "The change in morphology and behavior of a mature or immature natural killer T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific." [ISBN:0781735149, PMID:12154375, PMID:9133426] comment: Note that NK T cells are a distinct lineage of T cells expressing natural killer cell markers and having T cell receptors characterized by the usage of a restricted repertoire of variable region gene segments. synonym: "natural killer T cell activation" EXACT [] synonym: "natural T cell activation" EXACT [] synonym: "NK T lymphocyte activation" EXACT [] synonym: "NK T-cell activation" EXACT [] synonym: "NK T-lymphocyte activation" EXACT [] synonym: "NKT cell activation" EXACT [] synonym: "NT cell activation" EXACT [] is_a: GO:0046631 ! alpha-beta T cell activation intersection_of: GO:0001775 ! cell activation intersection_of: RO:0004009 CL:0000814 ! has primary input mature NK T cell relationship: RO:0004009 CL:0000814 ! has primary input mature NK T cell [Term] id: GO:0051133 name: regulation of NK T cell activation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of natural killer T cell activation." [ISBN:0781735149, PMID:12154375, PMID:9133426] synonym: "regulation of natural killer T cell activation" EXACT [] synonym: "regulation of natural T cell activation" EXACT [] synonym: "regulation of NK T lymphocyte activation" EXACT [] synonym: "regulation of NK T-cell activation" EXACT [] synonym: "regulation of NK T-lymphocyte activation" EXACT [] synonym: "regulation of NKT cell activation" EXACT [] synonym: "regulation of NT cell activation" EXACT [] is_a: GO:0046634 ! regulation of alpha-beta T cell activation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0051132 ! regulates NK T cell activation relationship: RO:0002211 GO:0051132 ! regulates NK T cell activation [Term] id: GO:0051134 name: negative regulation of NK T cell activation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of natural killer T cell activation." [ISBN:0781735149, PMID:12154375, PMID:9133426] synonym: "down regulation of NK T cell activation" EXACT [] synonym: "down-regulation of NK T cell activation" EXACT [] synonym: "downregulation of NK T cell activation" EXACT [] synonym: "inhibition of NK T cell activation" NARROW [] synonym: "negative regulation of natural killer T cell activation" EXACT [] synonym: "negative regulation of natural T cell activation" EXACT [] synonym: "negative regulation of NK T lymphocyte activation" EXACT [] synonym: "negative regulation of NK T-cell activation" EXACT [] synonym: "negative regulation of NK T-lymphocyte activation" EXACT [] synonym: "negative regulation of NKT cell activation" EXACT [] synonym: "negative regulation of NT cell activation" EXACT [] is_a: GO:0046636 ! negative regulation of alpha-beta T cell activation is_a: GO:0051133 ! regulation of NK T cell activation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0051132 ! negatively regulates NK T cell activation relationship: RO:0002212 GO:0051132 ! negatively regulates NK T cell activation [Term] id: GO:0051135 name: positive regulation of NK T cell activation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of natural killer T cell activation." [ISBN:0781735149, PMID:12154375, PMID:9133426] synonym: "activation of NK T cell activation" NARROW [] synonym: "positive regulation of natural killer T cell activation" EXACT [] synonym: "positive regulation of natural T cell activation" EXACT [] synonym: "positive regulation of NK T lymphocyte activation" EXACT [] synonym: "positive regulation of NK T-cell activation" EXACT [] synonym: "positive regulation of NK T-lymphocyte activation" EXACT [] synonym: "positive regulation of NKT cell activation" EXACT [] synonym: "positive regulation of NT cell activation" EXACT [] synonym: "stimulation of NK T cell activation" NARROW [] synonym: "up regulation of NK T cell activation" EXACT [] synonym: "up-regulation of NK T cell activation" EXACT [] synonym: "upregulation of NK T cell activation" EXACT [] is_a: GO:0046635 ! positive regulation of alpha-beta T cell activation is_a: GO:0051133 ! regulation of NK T cell activation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0051132 ! positively regulates NK T cell activation relationship: RO:0002213 GO:0051132 ! positively regulates NK T cell activation [Term] id: GO:0051136 name: regulation of NK T cell differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of natural killer T cell differentiation." [ISBN:0781735149, PMID:12154375, PMID:9133426] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "regulation of natural killer T cell differentiation" EXACT [] synonym: "regulation of natural T cell differentiation" EXACT [] synonym: "regulation of NK T cell development" RELATED [GOC:add] synonym: "regulation of NK T lymphocyte differentiation" EXACT [] synonym: "regulation of NK T-cell differentiation" EXACT [] synonym: "regulation of NK T-lymphocyte differentiation" EXACT [] synonym: "regulation of NKT cell differentiation" EXACT [] synonym: "regulation of NT cell differentiation" EXACT [] is_a: GO:0046637 ! regulation of alpha-beta T cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0001865 ! regulates NK T cell differentiation relationship: RO:0002211 GO:0001865 ! regulates NK T cell differentiation [Term] id: GO:0051137 name: negative regulation of NK T cell differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of natural killer T cell differentiation." [ISBN:0781735149, PMID:12154375, PMID:9133426] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "down regulation of NK T cell differentiation" EXACT [] synonym: "down-regulation of NK T cell differentiation" EXACT [] synonym: "downregulation of NK T cell differentiation" EXACT [] synonym: "inhibition of NK T cell differentiation" NARROW [] synonym: "negative regulation of natural killer T cell differentiation" EXACT [] synonym: "negative regulation of natural T cell differentiation" EXACT [] synonym: "negative regulation of NK T cell development" RELATED [GOC:add] synonym: "negative regulation of NK T lymphocyte differentiation" EXACT [] synonym: "negative regulation of NK T-cell differentiation" EXACT [] synonym: "negative regulation of NK T-lymphocyte differentiation" EXACT [] synonym: "negative regulation of NKT cell differentiation" EXACT [] synonym: "negative regulation of NT cell differentiation" EXACT [] is_a: GO:0046639 ! negative regulation of alpha-beta T cell differentiation is_a: GO:0051136 ! regulation of NK T cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0001865 ! negatively regulates NK T cell differentiation relationship: RO:0002212 GO:0001865 ! negatively regulates NK T cell differentiation [Term] id: GO:0051138 name: positive regulation of NK T cell differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of natural killer T cell differentiation." [ISBN:0781735149, PMID:12154375, PMID:9133426] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "activation of NK T cell differentiation" NARROW [] synonym: "positive regulation of natural killer T cell differentiation" EXACT [] synonym: "positive regulation of natural T cell differentiation" EXACT [] synonym: "positive regulation of NK T cell development" RELATED [GOC:add] synonym: "positive regulation of NK T lymphocyte differentiation" EXACT [] synonym: "positive regulation of NK T-cell differentiation" EXACT [] synonym: "positive regulation of NK T-lymphocyte differentiation" EXACT [] synonym: "positive regulation of NKT cell differentiation" EXACT [] synonym: "positive regulation of NT cell differentiation" EXACT [] synonym: "stimulation of NK T cell differentiation" NARROW [] synonym: "up regulation of NK T cell differentiation" EXACT [] synonym: "up-regulation of NK T cell differentiation" EXACT [] synonym: "upregulation of NK T cell differentiation" EXACT [] is_a: GO:0046638 ! positive regulation of alpha-beta T cell differentiation is_a: GO:0051136 ! regulation of NK T cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0001865 ! positively regulates NK T cell differentiation relationship: RO:0002213 GO:0001865 ! positively regulates NK T cell differentiation [Term] id: GO:0051140 name: regulation of NK T cell proliferation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of natural killer T cell proliferation." [ISBN:0781735149, PMID:12154375, PMID:9133426] synonym: "regulation of natural killer T cell proliferation" EXACT [] synonym: "regulation of natural T cell proliferation" EXACT [] synonym: "regulation of NK T lymphocyte proliferation" EXACT [] synonym: "regulation of NK T-cell proliferation" EXACT [] synonym: "regulation of NK T-lymphocyte proliferation" EXACT [] synonym: "regulation of NKT cell proliferation" EXACT [] synonym: "regulation of NT cell proliferation" EXACT [] is_a: GO:0046640 ! regulation of alpha-beta T cell proliferation is_a: GO:0051133 ! regulation of NK T cell activation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0001866 ! regulates NK T cell proliferation relationship: RO:0002211 GO:0001866 ! regulates NK T cell proliferation [Term] id: GO:0051141 name: negative regulation of NK T cell proliferation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of natural killer T cell proliferation." [ISBN:0781735149, PMID:12154375, PMID:9133426] synonym: "down regulation of NK T cell proliferation" EXACT [] synonym: "down-regulation of NK T cell proliferation" EXACT [] synonym: "downregulation of NK T cell proliferation" EXACT [] synonym: "inhibition of NK T cell proliferation" NARROW [] synonym: "negative regulation of natural killer T cell proliferation" EXACT [] synonym: "negative regulation of natural T cell proliferation" EXACT [] synonym: "negative regulation of NK T lymphocyte proliferation" EXACT [] synonym: "negative regulation of NK T-cell proliferation" EXACT [] synonym: "negative regulation of NK T-lymphocyte proliferation" EXACT [] synonym: "negative regulation of NKT cell proliferation" EXACT [] synonym: "negative regulation of NT cell proliferation" EXACT [] is_a: GO:0046642 ! negative regulation of alpha-beta T cell proliferation is_a: GO:0051134 ! negative regulation of NK T cell activation is_a: GO:0051140 ! regulation of NK T cell proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0001866 ! negatively regulates NK T cell proliferation relationship: RO:0002212 GO:0001866 ! negatively regulates NK T cell proliferation [Term] id: GO:0051142 name: positive regulation of NK T cell proliferation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of natural killer T cell proliferation." [ISBN:0781735149, PMID:12154375, PMID:9133426] synonym: "activation of NK T cell proliferation" NARROW [] synonym: "positive regulation of natural killer T cell proliferation" EXACT [] synonym: "positive regulation of natural T cell proliferation" EXACT [] synonym: "positive regulation of NK T lymphocyte proliferation" EXACT [] synonym: "positive regulation of NK T-cell proliferation" EXACT [] synonym: "positive regulation of NK T-lymphocyte proliferation" EXACT [] synonym: "positive regulation of NKT cell proliferation" EXACT [] synonym: "positive regulation of NT cell proliferation" EXACT [] synonym: "stimulation of NK T cell proliferation" NARROW [] synonym: "up regulation of NK T cell proliferation" EXACT [] synonym: "up-regulation of NK T cell proliferation" EXACT [] synonym: "upregulation of NK T cell proliferation" EXACT [] is_a: GO:0046641 ! positive regulation of alpha-beta T cell proliferation is_a: GO:0051135 ! positive regulation of NK T cell activation is_a: GO:0051140 ! regulation of NK T cell proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0001866 ! positively regulates NK T cell proliferation relationship: RO:0002213 GO:0001866 ! positively regulates NK T cell proliferation [Term] id: GO:0051145 name: smooth muscle cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a smooth muscle cell; smooth muscle lacks transverse striations in its constituent fibers and are almost always involuntary." [CL:0000192, GOC:ai] synonym: "nonstriated muscle cell differentiation" EXACT [] is_a: GO:0042692 ! muscle cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000192 ! results in acquisition of features of smooth muscle cell relationship: RO:0002315 CL:0000192 ! results in acquisition of features of smooth muscle cell [Term] id: GO:0051146 name: striated muscle cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a striated muscle cell; striated muscle fibers are divided by transverse bands into striations, and cardiac and voluntary muscle are types of striated muscle." [CL:0000737, GOC:ai] synonym: "voluntary muscle cell differentiation" NARROW [] is_a: GO:0042692 ! muscle cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000737 ! results in acquisition of features of striated muscle cell relationship: RO:0002315 CL:0000737 ! results in acquisition of features of striated muscle cell [Term] id: GO:0051147 name: regulation of muscle cell differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of muscle cell differentiation." [CL:0000187, GOC:ai] is_a: GO:0045595 ! regulation of cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0042692 ! regulates muscle cell differentiation relationship: RO:0002211 GO:0042692 ! regulates muscle cell differentiation [Term] id: GO:0051148 name: negative regulation of muscle cell differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of muscle cell differentiation." [CL:0000187, GOC:ai] synonym: "down regulation of muscle cell differentiation" EXACT [] synonym: "down-regulation of muscle cell differentiation" EXACT [] synonym: "downregulation of muscle cell differentiation" EXACT [] synonym: "inhibition of muscle cell differentiation" NARROW [] is_a: GO:0045596 ! negative regulation of cell differentiation is_a: GO:0051147 ! regulation of muscle cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0042692 ! negatively regulates muscle cell differentiation relationship: RO:0002212 GO:0042692 ! negatively regulates muscle cell differentiation [Term] id: GO:0051149 name: positive regulation of muscle cell differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of muscle cell differentiation." [CL:0000187, GOC:ai] synonym: "activation of muscle cell differentiation" NARROW [] synonym: "stimulation of muscle cell differentiation" NARROW [] synonym: "up regulation of muscle cell differentiation" EXACT [] synonym: "up-regulation of muscle cell differentiation" EXACT [] synonym: "upregulation of muscle cell differentiation" EXACT [] xref: Reactome:R-HSA-525793 "Myogenesis" is_a: GO:0045597 ! positive regulation of cell differentiation is_a: GO:0051147 ! regulation of muscle cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0042692 ! positively regulates muscle cell differentiation relationship: RO:0002213 GO:0042692 ! positively regulates muscle cell differentiation [Term] id: GO:0051150 name: regulation of smooth muscle cell differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of smooth muscle cell differentiation." [CL:0000192, GOC:ai] is_a: GO:0051147 ! regulation of muscle cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0051145 ! regulates smooth muscle cell differentiation relationship: RO:0002211 GO:0051145 ! regulates smooth muscle cell differentiation [Term] id: GO:0051151 name: negative regulation of smooth muscle cell differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of smooth muscle cell differentiation." [CL:0000192, GOC:ai] synonym: "down regulation of smooth muscle cell differentiation" EXACT [] synonym: "down-regulation of smooth muscle cell differentiation" EXACT [] synonym: "downregulation of smooth muscle cell differentiation" EXACT [] synonym: "inhibition of smooth muscle cell differentiation" NARROW [] is_a: GO:0051148 ! negative regulation of muscle cell differentiation is_a: GO:0051150 ! regulation of smooth muscle cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0051145 ! negatively regulates smooth muscle cell differentiation relationship: RO:0002212 GO:0051145 ! negatively regulates smooth muscle cell differentiation [Term] id: GO:0051152 name: positive regulation of smooth muscle cell differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of smooth muscle cell differentiation." [CL:0000192, GOC:ai] synonym: "activation of smooth muscle cell differentiation" NARROW [] synonym: "stimulation of smooth muscle cell differentiation" NARROW [] synonym: "up regulation of smooth muscle cell differentiation" EXACT [] synonym: "up-regulation of smooth muscle cell differentiation" EXACT [] synonym: "upregulation of smooth muscle cell differentiation" EXACT [] is_a: GO:0051149 ! positive regulation of muscle cell differentiation is_a: GO:0051150 ! regulation of smooth muscle cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0051145 ! positively regulates smooth muscle cell differentiation relationship: RO:0002213 GO:0051145 ! positively regulates smooth muscle cell differentiation [Term] id: GO:0051153 name: regulation of striated muscle cell differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of striated muscle cell differentiation." [CL:0000737, GOC:ai] is_a: GO:0051147 ! regulation of muscle cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0051146 ! regulates striated muscle cell differentiation relationship: RO:0002211 GO:0051146 ! regulates striated muscle cell differentiation [Term] id: GO:0051154 name: negative regulation of striated muscle cell differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of striated muscle cell differentiation." [CL:0000737, GOC:ai] synonym: "down regulation of striated muscle cell differentiation" EXACT [] synonym: "down-regulation of striated muscle cell differentiation" EXACT [] synonym: "downregulation of striated muscle cell differentiation" EXACT [] synonym: "inhibition of striated muscle cell differentiation" NARROW [] is_a: GO:0051148 ! negative regulation of muscle cell differentiation is_a: GO:0051153 ! regulation of striated muscle cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0051146 ! negatively regulates striated muscle cell differentiation relationship: RO:0002212 GO:0051146 ! negatively regulates striated muscle cell differentiation [Term] id: GO:0051155 name: positive regulation of striated muscle cell differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of striated muscle cell differentiation." [CL:0000737, GOC:ai] synonym: "activation of striated muscle cell differentiation" NARROW [] synonym: "stimulation of striated muscle cell differentiation" NARROW [] synonym: "up regulation of striated muscle cell differentiation" EXACT [] synonym: "up-regulation of striated muscle cell differentiation" EXACT [] synonym: "upregulation of striated muscle cell differentiation" EXACT [] is_a: GO:0051149 ! positive regulation of muscle cell differentiation is_a: GO:0051153 ! regulation of striated muscle cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0051146 ! positively regulates striated muscle cell differentiation relationship: RO:0002213 GO:0051146 ! positively regulates striated muscle cell differentiation [Term] id: GO:0051168 name: nuclear export namespace: biological_process def: "The directed movement of substances out of the nucleus." [GOC:ai] synonym: "export from nucleus" EXACT [] synonym: "nucleus export" EXACT [] synonym: "substance nuclear export" EXACT [] is_a: GO:0006913 ! nucleocytoplasmic transport intersection_of: GO:0006810 ! transport intersection_of: RO:0002338 GO:0031981 ! has target start location nuclear lumen intersection_of: RO:0002339 GO:0005829 ! has target end location cytosol intersection_of: RO:0002342 GO:0005635 ! results in transport across nuclear envelope relationship: RO:0002338 GO:0031981 ! has target start location nuclear lumen relationship: RO:0002339 GO:0005829 ! has target end location cytosol [Term] id: GO:0051169 name: nuclear transport namespace: biological_process def: "The directed movement of substances into, out of, or within the nucleus." [GOC:ai] subset: goslim_yeast synonym: "nucleus transport" EXACT [] xref: Wikipedia:Nuclear_transport is_a: GO:0046907 ! intracellular transport intersection_of: GO:0046907 ! intracellular transport intersection_of: RO:0002344 GO:0005634 ! results in transport to from or in nucleus relationship: RO:0002344 GO:0005634 ! results in transport to from or in nucleus [Term] id: GO:0051170 name: import into nucleus namespace: biological_process def: "The directed movement of substances into the nucleus." [GOC:ai] synonym: "nuclear import" EXACT [] synonym: "nuclear translocation" EXACT [] is_a: GO:0006913 ! nucleocytoplasmic transport intersection_of: GO:0006810 ! transport intersection_of: RO:0002338 GO:0005829 ! has target start location cytosol intersection_of: RO:0002339 GO:0031981 ! has target end location nuclear lumen intersection_of: RO:0002342 GO:0005635 ! results in transport across nuclear envelope relationship: RO:0002338 GO:0005829 ! has target start location cytosol relationship: RO:0002339 GO:0031981 ! has target end location nuclear lumen creation_date: 2013-12-19T15:26:34Z [Term] id: GO:0051174 name: regulation of phosphorus metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving phosphorus or compounds containing phosphorus." [GOC:ai] synonym: "regulation of phosphorus metabolism" EXACT [] is_a: GO:0019222 ! regulation of metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0006793 ! regulates phosphorus metabolic process relationship: RO:0002211 GO:0006793 ! regulates phosphorus metabolic process [Term] id: GO:0051179 name: localization namespace: biological_process def: "Any process in which a cell, a substance, or a cellular entity, such as a protein complex or organelle, is transported, tethered to or otherwise maintained in a specific location. In the case of substances, localization may also be achieved via selective degradation." [GOC:ai, GOC:dos] subset: gocheck_do_not_annotate subset: goslim_pir synonym: "establishment and maintenance of cellular component location" NARROW [] synonym: "establishment and maintenance of localization" EXACT [] synonym: "establishment and maintenance of position" EXACT [] synonym: "establishment and maintenance of substance location" NARROW [] synonym: "establishment and maintenance of substrate location" NARROW [] synonym: "localisation" EXACT [GOC:mah] synonym: "single organism localization" RELATED [GOC:TermGenie] synonym: "single-organism localization" RELATED [] is_a: GO:0008150 ! biological_process property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/27052" xsd:anyURI creation_date: 2013-12-18T13:51:04Z [Term] id: GO:0051208 name: sequestering of calcium ion namespace: biological_process def: "The process of binding or confining calcium ions such that they are separated from other components of a biological system." [GOC:ai] synonym: "calcium ion (Ca2+) retention" EXACT [] synonym: "calcium ion (Ca2+) sequestering" EXACT [] synonym: "calcium ion (Ca2+) sequestration" EXACT [] synonym: "calcium ion (Ca2+) storage" EXACT [] synonym: "calcium ion storage activity" RELATED [] synonym: "negative regulation of calcium ion (Ca2+) transport" RELATED [] synonym: "retention of calcium ion (Ca2+)" EXACT [] synonym: "sequestering of calcium ion (Ca2+)" EXACT [] synonym: "sequestration of calcium ion (Ca2+)" EXACT [] synonym: "storage of calcium ion (Ca2+)" EXACT [] is_a: GO:0051651 ! maintenance of location in cell intersection_of: GO:0051235 ! maintenance of location intersection_of: RO:0004009 CHEBI:29108 ! has primary input relationship: BFO:0000050 GO:0006874 ! part of intracellular calcium ion homeostasis relationship: RO:0004009 CHEBI:29108 ! has primary input [Term] id: GO:0051209 name: release of sequestered calcium ion into cytosol namespace: biological_process def: "The process in which calcium ions sequestered in the endoplasmic reticulum, Golgi apparatus or mitochondria are released into the cytosolic compartment." [GOC:dph, GOC:hjd, GOC:mtg_lung, PMID:1814929] synonym: "calcium ion (Ca2+) mobilization" BROAD [] synonym: "calcium mobilization" BROAD [] synonym: "cytoplasmic release of sequestered calcium ion (Ca2+)" BROAD [] synonym: "cytoplasmic release of stored calcium ion (Ca2+)" BROAD [] synonym: "cytosolic release of sequestered calcium ion (Ca2+)" EXACT [] synonym: "cytosolic release of stored calcium ion (Ca2+)" EXACT [] synonym: "release of sequestered calcium ion (Ca2+)" BROAD [] synonym: "release of sequestered calcium ion into cytoplasm" BROAD [] synonym: "release of stored calcium ion (Ca2+)" BROAD [] synonym: "release of stored calcium ion (Ca2+) into cytoplasm" BROAD [] synonym: "release of stored calcium ion (Ca2+) into cytosol" EXACT [] is_a: GO:0051283 ! negative regulation of sequestering of calcium ion is_a: GO:0097553 ! calcium ion transmembrane import into cytosol intersection_of: GO:0055085 ! transmembrane transport intersection_of: RO:0002338 GO:0043231 ! has target start location intracellular membrane-bounded organelle intersection_of: RO:0002339 GO:0005829 ! has target end location cytosol intersection_of: RO:0004009 CHEBI:29108 ! has primary input relationship: RO:0002338 GO:0043231 ! has target start location intracellular membrane-bounded organelle [Term] id: GO:0051216 name: cartilage development namespace: biological_process def: "The process whose specific outcome is the progression of a cartilage element over time, from its formation to the mature structure. Cartilage elements are skeletal elements that consist of connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate." [GOC:cjm, PMID:23251424] synonym: "cartilage biogenesis" EXACT [] synonym: "cartilage biosynthesis" EXACT [] synonym: "cartilage element development" EXACT [] synonym: "cartilage formation" EXACT [] synonym: "cartilage organ development" EXACT [] synonym: "chondrogenesis" EXACT [] xref: Wikipedia:Chondrogenesis is_a: GO:0048513 ! animal organ development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0007844 ! results in development of cartilage element relationship: BFO:0000050 GO:0001501 ! part of skeletal system development relationship: BFO:0000050 GO:0061448 ! part of connective tissue development relationship: RO:0002296 UBERON:0007844 ! results in development of cartilage element [Term] id: GO:0051222 name: positive regulation of protein transport namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the directed movement of a protein into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] synonym: "activation of protein transport" NARROW [] synonym: "stimulation of protein transport" NARROW [] synonym: "up regulation of protein transport" EXACT [] synonym: "up-regulation of protein transport" EXACT [] synonym: "upregulation of protein transport" EXACT [] is_a: GO:0051050 ! positive regulation of transport is_a: GO:0051223 ! regulation of protein transport is_a: GO:1903829 ! positive regulation of protein localization is_a: GO:1904951 ! positive regulation of establishment of protein localization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0015031 ! positively regulates protein transport relationship: RO:0002213 GO:0015031 ! positively regulates protein transport [Term] id: GO:0051223 name: regulation of protein transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the directed movement of a protein into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] is_a: GO:0051049 ! regulation of transport is_a: GO:0070201 ! regulation of establishment of protein localization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0015031 ! regulates protein transport relationship: RO:0002211 GO:0015031 ! regulates protein transport [Term] id: GO:0051224 name: negative regulation of protein transport namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of a protein into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] synonym: "down regulation of protein transport" EXACT [] synonym: "down-regulation of protein transport" EXACT [] synonym: "downregulation of protein transport" EXACT [] synonym: "inhibition of protein transport" NARROW [] is_a: GO:0051051 ! negative regulation of transport is_a: GO:0051223 ! regulation of protein transport is_a: GO:1903828 ! negative regulation of protein localization is_a: GO:1904950 ! negative regulation of establishment of protein localization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0015031 ! negatively regulates protein transport relationship: RO:0002212 GO:0015031 ! negatively regulates protein transport [Term] id: GO:0051234 name: establishment of localization namespace: biological_process def: "Any process that localizes a substance or cellular component. This may occur via movement, tethering or selective degradation." [GOC:ai, GOC:dos] subset: gocheck_do_not_annotate subset: goslim_agr subset: goslim_flybase_ribbon subset: goslim_mouse subset: goslim_pir synonym: "establishment of localisation" EXACT [GOC:mah] is_a: GO:0051179 ! localization property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/24200" xsd:anyURI [Term] id: GO:0051235 name: maintenance of location namespace: biological_process def: "Any process in which a cell, substance or cellular entity, such as a protein complex or organelle, is maintained in a location and prevented from moving elsewhere." [GOC:ai, GOC:dph, GOC:tb] synonym: "maintenance of localization" EXACT [] synonym: "retention" NARROW [] synonym: "sequestering" NARROW [] synonym: "storage" NARROW [] is_a: GO:0051179 ! localization [Term] id: GO:0051236 name: establishment of RNA localization namespace: biological_process def: "The directed movement of RNA to a specific location." [GOC:ai] synonym: "establishment of RNA localisation" EXACT [GOC:mah] synonym: "RNA positioning" EXACT [] synonym: "RNA recruitment" EXACT [] is_a: GO:0051234 ! establishment of localization relationship: BFO:0000050 GO:0006403 ! part of RNA localization [Term] id: GO:0051239 name: regulation of multicellular organismal process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of a multicellular organismal process, the processes pertinent to the function of a multicellular organism above the cellular level; includes the integrated processes of tissues and organs." [GOC:ai, GOC:dph, GOC:tb] is_a: GO:0050789 ! regulation of biological process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0032501 ! regulates multicellular organismal process relationship: RO:0002211 GO:0032501 ! regulates multicellular organismal process property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0051240 name: positive regulation of multicellular organismal process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of an organismal process, any of the processes pertinent to the function of an organism above the cellular level; includes the integrated processes of tissues and organs." [GOC:ai] synonym: "activation of multicellular organismal process" NARROW [] synonym: "stimulation of multicellular organismal process" NARROW [] synonym: "up regulation of multicellular organismal process" EXACT [] synonym: "up-regulation of multicellular organismal process" EXACT [] synonym: "upregulation of multicellular organismal process" EXACT [] is_a: GO:0048518 ! positive regulation of biological process is_a: GO:0051239 ! regulation of multicellular organismal process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0032501 ! positively regulates multicellular organismal process relationship: RO:0002213 GO:0032501 ! positively regulates multicellular organismal process property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0051241 name: negative regulation of multicellular organismal process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of an organismal process, the processes pertinent to the function of an organism above the cellular level; includes the integrated processes of tissues and organs." [GOC:ai] synonym: "down regulation of multicellular organismal process" EXACT [] synonym: "down-regulation of multicellular organismal process" EXACT [] synonym: "downregulation of multicellular organismal process" EXACT [] synonym: "inhibition of multicellular organismal process" NARROW [] is_a: GO:0048519 ! negative regulation of biological process is_a: GO:0051239 ! regulation of multicellular organismal process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0032501 ! negatively regulates multicellular organismal process relationship: RO:0002212 GO:0032501 ! negatively regulates multicellular organismal process property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0051246 name: regulation of protein metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a protein." [GOC:ai] synonym: "regulation of cellular protein metabolic process" RELATED [] synonym: "regulation of cellular protein metabolism" RELATED [] synonym: "regulation of protein metabolism" EXACT [] is_a: GO:0060255 ! regulation of macromolecule metabolic process is_a: GO:0080090 ! regulation of primary metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0019538 ! regulates protein metabolic process relationship: RO:0002211 GO:0019538 ! regulates protein metabolic process property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/23112" xsd:anyURI [Term] id: GO:0051247 name: positive regulation of protein metabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving a protein." [GOC:ai] synonym: "activation of cellular protein metabolic process" NARROW [] synonym: "activation of protein metabolic process" NARROW [] synonym: "positive regulation of cellular protein metabolic process" EXACT [] synonym: "positive regulation of cellular protein metabolism" EXACT [] synonym: "positive regulation of protein metabolism" EXACT [] synonym: "stimulation of cellular protein metabolic process" NARROW [] synonym: "stimulation of protein metabolic process" NARROW [] synonym: "up regulation of cellular protein metabolic process" EXACT [] synonym: "up regulation of protein metabolic process" EXACT [] synonym: "up-regulation of cellular protein metabolic process" EXACT [] synonym: "up-regulation of protein metabolic process" EXACT [] synonym: "upregulation of cellular protein metabolic process" EXACT [] synonym: "upregulation of protein metabolic process" EXACT [] is_a: GO:0010604 ! positive regulation of macromolecule metabolic process is_a: GO:0051246 ! regulation of protein metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0019538 ! positively regulates protein metabolic process relationship: RO:0002213 GO:0019538 ! positively regulates protein metabolic process property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/23112" xsd:anyURI [Term] id: GO:0051248 name: negative regulation of protein metabolic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of chemical reactions and pathways involving a protein." [GOC:ai] synonym: "down regulation of cellular protein metabolic process" EXACT [] synonym: "down regulation of protein metabolic process" EXACT [] synonym: "down-regulation of cellular protein metabolic process" EXACT [] synonym: "down-regulation of protein metabolic process" EXACT [] synonym: "downregulation of cellular protein metabolic process" EXACT [] synonym: "downregulation of protein metabolic process" EXACT [] synonym: "inhibition of cellular protein metabolic process" NARROW [] synonym: "inhibition of protein metabolic process" NARROW [] synonym: "negative regulation of cellular protein metabolic process" EXACT [] synonym: "negative regulation of cellular protein metabolism" EXACT [] synonym: "negative regulation of protein metabolism" EXACT [] is_a: GO:0010605 ! negative regulation of macromolecule metabolic process is_a: GO:0051246 ! regulation of protein metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0019538 ! negatively regulates protein metabolic process relationship: RO:0002212 GO:0019538 ! negatively regulates protein metabolic process property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/23112" xsd:anyURI [Term] id: GO:0051249 name: regulation of lymphocyte activation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of lymphocyte activation." [GOC:ai] is_a: GO:0002694 ! regulation of leukocyte activation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0046649 ! regulates lymphocyte activation relationship: RO:0002211 GO:0046649 ! regulates lymphocyte activation [Term] id: GO:0051250 name: negative regulation of lymphocyte activation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of lymphocyte activation." [GOC:ai] synonym: "down regulation of lymphocyte activation" EXACT [] synonym: "down-regulation of lymphocyte activation" EXACT [] synonym: "downregulation of lymphocyte activation" EXACT [] synonym: "inhibition of lymphocyte activation" NARROW [] is_a: GO:0002695 ! negative regulation of leukocyte activation is_a: GO:0051249 ! regulation of lymphocyte activation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0046649 ! negatively regulates lymphocyte activation relationship: RO:0002212 GO:0046649 ! negatively regulates lymphocyte activation [Term] id: GO:0051251 name: positive regulation of lymphocyte activation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of lymphocyte activation." [GOC:ai] synonym: "activation of lymphocyte activation" NARROW [] synonym: "stimulation of lymphocyte activation" NARROW [] synonym: "up regulation of lymphocyte activation" EXACT [] synonym: "up-regulation of lymphocyte activation" EXACT [] synonym: "upregulation of lymphocyte activation" EXACT [] is_a: GO:0002696 ! positive regulation of leukocyte activation is_a: GO:0051249 ! regulation of lymphocyte activation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0046649 ! positively regulates lymphocyte activation relationship: RO:0002213 GO:0046649 ! positively regulates lymphocyte activation [Term] id: GO:0051252 name: regulation of RNA metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving RNA." [GOC:ai] synonym: "regulation of RNA metabolism" EXACT [] is_a: GO:0019219 ! regulation of nucleobase-containing compound metabolic process is_a: GO:0060255 ! regulation of macromolecule metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0016070 ! regulates RNA metabolic process relationship: RO:0002211 GO:0016070 ! regulates RNA metabolic process [Term] id: GO:0051253 name: negative regulation of RNA metabolic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving RNA." [GOC:ai] subset: gocheck_do_not_annotate synonym: "down regulation of RNA metabolic process" EXACT [] synonym: "down-regulation of RNA metabolic process" EXACT [] synonym: "downregulation of RNA metabolic process" EXACT [] synonym: "inhibition of RNA metabolic process" NARROW [] synonym: "negative regulation of RNA metabolism" EXACT [] is_a: GO:0010605 ! negative regulation of macromolecule metabolic process is_a: GO:0045934 ! negative regulation of nucleobase-containing compound metabolic process is_a: GO:0051252 ! regulation of RNA metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0016070 ! negatively regulates RNA metabolic process relationship: RO:0002212 GO:0016070 ! negatively regulates RNA metabolic process property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/30771" xsd:anyURI [Term] id: GO:0051254 name: positive regulation of RNA metabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving RNA." [GOC:ai] synonym: "activation of RNA metabolic process" NARROW [] synonym: "positive regulation of RNA metabolism" EXACT [] synonym: "stimulation of RNA metabolic process" NARROW [] synonym: "up regulation of RNA metabolic process" EXACT [] synonym: "up-regulation of RNA metabolic process" EXACT [] synonym: "upregulation of RNA metabolic process" EXACT [] is_a: GO:0010604 ! positive regulation of macromolecule metabolic process is_a: GO:0051252 ! regulation of RNA metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0016070 ! positively regulates RNA metabolic process relationship: RO:0002213 GO:0016070 ! positively regulates RNA metabolic process [Term] id: GO:0051258 name: protein polymerization namespace: biological_process def: "The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein." [GOC:ai] subset: goslim_pir synonym: "protein polymer biosynthesis" EXACT [] synonym: "protein polymer biosynthetic process" EXACT [] synonym: "protein polymer formation" EXACT [] is_a: GO:0065003 ! protein-containing complex assembly [Term] id: GO:0051261 name: protein depolymerization namespace: biological_process def: "The process in which protein polymers, compounds composed of a large number of component monomers, are broken down. Depolymerization occurs by the successive removal of monomers from an existing poly- or oligomeric protein." [GOC:ai] subset: goslim_pir synonym: "protein polymer breakdown" EXACT [] synonym: "protein polymer catabolic process" EXACT [] synonym: "protein polymer catabolism" EXACT [] synonym: "protein polymer degradation" EXACT [] is_a: GO:0032984 ! protein-containing complex disassembly [Term] id: GO:0051276 name: chromosome organization namespace: biological_process def: "A process that is carried out at the cellular level that results in the assembly, arrangement of constituent parts, or disassembly of chromosomes, structures composed of a very long molecule of DNA and associated proteins that carries hereditary information. This term covers covalent modifications at the molecular level as well as spatial relationships among the major components of a chromosome." [GOC:ai, GOC:dph, GOC:jl, GOC:mah] subset: goslim_chembl subset: goslim_drosophila subset: goslim_pir synonym: "chromosome organisation" EXACT [] synonym: "chromosome organization and biogenesis" RELATED [GOC:mah] synonym: "DNA condensation" EXACT [] synonym: "DNA packaging" NARROW [] synonym: "maintenance of genome integrity" RELATED [] synonym: "nuclear genome maintenance" RELATED [] is_a: GO:0006996 ! organelle organization intersection_of: GO:0016043 ! cellular component organization intersection_of: RO:0002592 GO:0005694 ! results in organization of chromosome relationship: RO:0002592 GO:0005694 ! results in organization of chromosome property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/22811" xsd:anyURI property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/4585" xsd:anyURI [Term] id: GO:0051279 name: regulation of release of sequestered calcium ion into cytosol namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the release into the cytosolic compartment of calcium ions sequestered in the endoplasmic reticulum or mitochondria." [GOC:ai, GOC:tb] synonym: "regulation of calcium ion (Ca2+) mobilization" EXACT [] synonym: "regulation of calcium mobilization" EXACT [] synonym: "regulation of cytoplasmic release of sequestered calcium ion (Ca2+)" EXACT [] synonym: "regulation of cytoplasmic release of stored calcium ion (Ca2+)" EXACT [] synonym: "regulation of release of sequestered calcium ion (Ca2+)" BROAD [] synonym: "regulation of release of stored calcium ion (Ca2+)" BROAD [] synonym: "regulation of release of stored calcium ion (Ca2+) into cytoplasm" EXACT [] synonym: "regulation of release of stored calcium ion (Ca2+) into cytosol" EXACT [] is_a: GO:0051282 ! regulation of sequestering of calcium ion is_a: GO:1903169 ! regulation of calcium ion transmembrane transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0051209 ! regulates release of sequestered calcium ion into cytosol relationship: RO:0002211 GO:0051209 ! regulates release of sequestered calcium ion into cytosol [Term] id: GO:0051280 name: negative regulation of release of sequestered calcium ion into cytosol namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the release into the cytosolic compartment of calcium ions sequestered in the endoplasmic reticulum or mitochondria." [GOC:ai] synonym: "down regulation of release of sequestered calcium ion into cytosol" EXACT [] synonym: "down-regulation of release of sequestered calcium ion into cytosol" EXACT [] synonym: "downregulation of release of sequestered calcium ion into cytosol" EXACT [] synonym: "inhibition of release of sequestered calcium ion into cytosol" NARROW [] synonym: "negative regulation of calcium ion (Ca2+) mobilization" BROAD [] synonym: "negative regulation of calcium mobilization" BROAD [] synonym: "negative regulation of cytoplasmic release of sequestered calcium ion (Ca2+)" BROAD [] synonym: "negative regulation of cytoplasmic release of stored calcium ion (Ca2+)" BROAD [] synonym: "negative regulation of cytosolic release of sequestered calcium ion (Ca2+)" EXACT [] synonym: "negative regulation of cytosolic release of stored calcium ion (Ca2+)" EXACT [] synonym: "negative regulation of release of sequestered calcium ion (Ca2+)" BROAD [] synonym: "negative regulation of release of sequestered calcium ion into cytoplasm" BROAD [] synonym: "negative regulation of release of stored calcium ion (Ca2+)" BROAD [] synonym: "negative regulation of release of stored calcium ion (Ca2+) into cytoplasm" BROAD [] synonym: "negative regulation of release of stored calcium ion (Ca2+) into cytosol" EXACT [] is_a: GO:0051279 ! regulation of release of sequestered calcium ion into cytosol is_a: GO:0051284 ! positive regulation of sequestering of calcium ion is_a: GO:1903170 ! negative regulation of calcium ion transmembrane transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0051209 ! negatively regulates release of sequestered calcium ion into cytosol relationship: RO:0002212 GO:0051209 ! negatively regulates release of sequestered calcium ion into cytosol [Term] id: GO:0051281 name: positive regulation of release of sequestered calcium ion into cytosol namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the release into the cytosolic compartment of calcium ions sequestered in the endoplasmic reticulum or mitochondria." [GOC:ai] synonym: "activation of release of sequestered calcium ion into cytosol" NARROW [] synonym: "positive regulation of calcium ion (Ca2+) mobilization" BROAD [] synonym: "positive regulation of calcium mobilization" BROAD [] synonym: "positive regulation of cytoplasmic release of sequestered calcium ion (Ca2+)" BROAD [] synonym: "positive regulation of cytoplasmic release of stored calcium ion (Ca2+)" BROAD [] synonym: "positive regulation of cytosolic release of sequestered calcium ion (Ca2+)" EXACT [] synonym: "positive regulation of cytosolic release of stored calcium ion (Ca2+)" EXACT [] synonym: "positive regulation of release of sequestered calcium ion (Ca2+)" BROAD [] synonym: "positive regulation of release of sequestered calcium ion into cytoplasm" BROAD [] synonym: "positive regulation of release of stored calcium ion (Ca2+)" BROAD [] synonym: "positive regulation of release of stored calcium ion (Ca2+) into cytoplasm" BROAD [] synonym: "positive regulation of release of stored calcium ion (Ca2+) into cytosol" EXACT [] synonym: "stimulation of release of sequestered calcium ion into cytosol" NARROW [] synonym: "up regulation of release of sequestered calcium ion into cytosol" EXACT [] synonym: "up-regulation of release of sequestered calcium ion into cytosol" EXACT [] synonym: "upregulation of release of sequestered calcium ion into cytosol" EXACT [] is_a: GO:0051279 ! regulation of release of sequestered calcium ion into cytosol is_a: GO:1904427 ! positive regulation of calcium ion transmembrane transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0051209 ! positively regulates release of sequestered calcium ion into cytosol relationship: RO:0002213 GO:0051209 ! positively regulates release of sequestered calcium ion into cytosol [Term] id: GO:0051282 name: regulation of sequestering of calcium ion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the binding or confining calcium ions such that they are separated from other components of a biological system." [GOC:ai] synonym: "regulation of calcium ion (Ca2+) retention" EXACT [] synonym: "regulation of calcium ion (Ca2+) sequestering" EXACT [] synonym: "regulation of calcium ion (Ca2+) sequestration" EXACT [] synonym: "regulation of calcium ion (Ca2+) storage" EXACT [] synonym: "regulation of retention of calcium ion (Ca2+)" EXACT [] synonym: "regulation of sequestering of calcium ion (Ca2+)" EXACT [] synonym: "regulation of sequestration of calcium ion (Ca2+)" EXACT [] synonym: "regulation of storage of calcium ion (Ca2+)" EXACT [] is_a: GO:0032879 ! regulation of localization is_a: GO:0050794 ! regulation of cellular process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0051208 ! regulates sequestering of calcium ion relationship: RO:0002211 GO:0051208 ! regulates sequestering of calcium ion [Term] id: GO:0051283 name: negative regulation of sequestering of calcium ion namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the binding or confining calcium ions such that they are separated from other components of a biological system." [GOC:ai] synonym: "down regulation of sequestering of calcium ion" EXACT [] synonym: "down-regulation of sequestering of calcium ion" EXACT [] synonym: "downregulation of sequestering of calcium ion" EXACT [] synonym: "inhibition of sequestering of calcium ion" NARROW [] synonym: "negative regulation of calcium ion (Ca2+) retention" EXACT [] synonym: "negative regulation of calcium ion (Ca2+) sequestering" EXACT [] synonym: "negative regulation of calcium ion (Ca2+) sequestration" EXACT [] synonym: "negative regulation of calcium ion (Ca2+) storage" EXACT [] synonym: "negative regulation of retention of calcium ion (Ca2+)" EXACT [] synonym: "negative regulation of sequestering of calcium ion (Ca2+)" EXACT [] synonym: "negative regulation of sequestration of calcium ion (Ca2+)" EXACT [] synonym: "negative regulation of storage of calcium ion (Ca2+)" EXACT [] is_a: GO:0048523 ! negative regulation of cellular process is_a: GO:0051282 ! regulation of sequestering of calcium ion intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0051208 ! negatively regulates sequestering of calcium ion relationship: RO:0002212 GO:0051208 ! negatively regulates sequestering of calcium ion [Term] id: GO:0051284 name: positive regulation of sequestering of calcium ion namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the binding or confining calcium ions such that they are separated from other components of a biological system." [GOC:ai] synonym: "activation of sequestering of calcium ion" NARROW [] synonym: "positive regulation of calcium ion (Ca2+) retention" EXACT [] synonym: "positive regulation of calcium ion (Ca2+) sequestering" EXACT [] synonym: "positive regulation of calcium ion (Ca2+) sequestration" EXACT [] synonym: "positive regulation of calcium ion (Ca2+) storage" EXACT [] synonym: "positive regulation of retention of calcium ion (Ca2+)" EXACT [] synonym: "positive regulation of sequestering of calcium ion (Ca2+)" EXACT [] synonym: "positive regulation of sequestration of calcium ion (Ca2+)" EXACT [] synonym: "positive regulation of storage of calcium ion (Ca2+)" EXACT [] synonym: "stimulation of sequestering of calcium ion" NARROW [] synonym: "up regulation of sequestering of calcium ion" EXACT [] synonym: "up-regulation of sequestering of calcium ion" EXACT [] synonym: "upregulation of sequestering of calcium ion" EXACT [] is_a: GO:0048522 ! positive regulation of cellular process is_a: GO:0051282 ! regulation of sequestering of calcium ion intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0051208 ! positively regulates sequestering of calcium ion relationship: RO:0002213 GO:0051208 ! positively regulates sequestering of calcium ion [Term] id: GO:0051301 name: cell division namespace: biological_process def: "The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells." [GOC:di, GOC:go_curators, GOC:pr] comment: Note that this term differs from 'cytokinesis ; GO:0000910' in that cytokinesis does not include nuclear division. subset: goslim_chembl subset: goslim_drosophila subset: goslim_pir xref: Wikipedia:Cell_division is_a: GO:0009987 ! cellular process [Term] id: GO:0051302 name: regulation of cell division namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the physical partitioning and separation of a cell into daughter cells." [GOC:go_curators] is_a: GO:0050794 ! regulation of cellular process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0051301 ! regulates cell division relationship: RO:0002211 GO:0051301 ! regulates cell division [Term] id: GO:0051321 name: meiotic cell cycle namespace: biological_process def: "Progression through the phases of the meiotic cell cycle, in which canonically a cell replicates to produce four offspring with half the chromosomal content of the progenitor cell via two nuclear divisions." [GOC:ai] comment: Note that this term should not be confused with 'GO:0140013 ; meiotic nuclear division'. 'GO:0051321 ; meiotic cell cycle represents the entire mitotic cell cycle, while 'GO:0140013 meiotic nuclear division' specifically represents the actual nuclear division step of the mitotic cell cycle. subset: goslim_drosophila subset: goslim_yeast synonym: "meiosis" RELATED [] xref: Wikipedia:Meiosis is_a: BFO:0000003 is_a: GO:0007049 ! cell cycle is_a: GO:0022414 ! reproductive process intersection_of: GO:0007049 ! cell cycle intersection_of: BFO:0000051 GO:0140013 ! has part meiotic nuclear division relationship: BFO:0000050 GO:0019953 ! part of sexual reproduction relationship: BFO:0000051 GO:0140013 ! has part meiotic nuclear division property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/24599" xsd:anyURI [Term] id: GO:0051336 name: regulation of hydrolase activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of hydrolase activity, the catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [GOC:ai] subset: gocheck_obsoletion_candidate synonym: "hydrolase regulator" EXACT [] is_a: GO:0050790 ! regulation of catalytic activity intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0016787 ! regulates hydrolase activity relationship: RO:0002211 GO:0016787 ! regulates hydrolase activity [Term] id: GO:0051338 name: regulation of transferase activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of transferase activity, the catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [GOC:ai] comment: This term is useful for grouping, but is too general for manual annotation. Please use a child term instead. subset: gocheck_obsoletion_candidate synonym: "transferase regulator" EXACT [] is_a: GO:0050790 ! regulation of catalytic activity intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0016740 ! regulates transferase activity relationship: RO:0002211 GO:0016740 ! regulates transferase activity [Term] id: GO:0051345 name: positive regulation of hydrolase activity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of hydrolase activity, the catalysis of the hydrolysis of various bonds." [GOC:ai] subset: gocheck_obsoletion_candidate synonym: "activation of hydrolase activity" NARROW [] synonym: "hydrolase activator" EXACT [] synonym: "stimulation of hydrolase activity" NARROW [] synonym: "up regulation of hydrolase activity" EXACT [] synonym: "up-regulation of hydrolase activity" EXACT [] synonym: "upregulation of hydrolase activity" EXACT [] is_a: GO:0043085 ! positive regulation of catalytic activity is_a: GO:0051336 ! regulation of hydrolase activity intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0016787 ! positively regulates hydrolase activity relationship: RO:0002213 GO:0016787 ! positively regulates hydrolase activity [Term] id: GO:0051346 name: negative regulation of hydrolase activity namespace: biological_process def: "Any process that stops or reduces the rate of hydrolase activity, the catalysis of the hydrolysis of various bonds." [GOC:ai] subset: gocheck_obsoletion_candidate synonym: "down regulation of hydrolase activity" EXACT [] synonym: "down-regulation of hydrolase activity" EXACT [] synonym: "downregulation of hydrolase activity" EXACT [] synonym: "hydrolase inhibitor" EXACT [] synonym: "inhibition of hydrolase activity" NARROW [] is_a: GO:0043086 ! negative regulation of catalytic activity is_a: GO:0051336 ! regulation of hydrolase activity intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0016787 ! negatively regulates hydrolase activity relationship: RO:0002212 GO:0016787 ! negatively regulates hydrolase activity [Term] id: GO:0051355 name: proprioception involved in equilibrioception namespace: biological_process def: "The series of events contributing to equilibrioception by which an organism senses the position, location, orientation, and movement of the body and its parts. Proprioception plays an important role in the ability of an organism to perceive its orientation with respect to gravity." [GOC:ai] synonym: "equilibrioception by proprioception" EXACT [] synonym: "perception of orientation with respect to gravity by proprioception" EXACT [] synonym: "proprioception during equilibrioception" RELATED [GOC:dph, GOC:tb] is_a: GO:0019230 ! proprioception intersection_of: GO:0019230 ! proprioception intersection_of: BFO:0000050 GO:0050957 ! part of equilibrioception relationship: BFO:0000050 GO:0050957 ! part of equilibrioception [Term] id: GO:0051356 name: visual perception involved in equilibrioception namespace: biological_process def: "The series of events during equilibrioception required for an organism to receive a visual stimulus, convert it to a molecular signal, and recognize and characterize the signal. Visual input plays an important role in the ability of an organism to perceive its orientation with respect to gravity." [GOC:ai] synonym: "equilibrioception by visual perception" NARROW [] synonym: "perception of orientation with respect to gravity by visual perception" EXACT [] synonym: "visual perception during equilibrioception" RELATED [GOC:dph, GOC:tb] is_a: GO:0007601 ! visual perception intersection_of: GO:0007601 ! visual perception intersection_of: BFO:0000050 GO:0050957 ! part of equilibrioception relationship: BFO:0000050 GO:0050957 ! part of equilibrioception [Term] id: GO:0051378 name: serotonin binding namespace: molecular_function def: "Binding to serotonin (5-hydroxytryptamine), a monoamine neurotransmitter occurring in the peripheral and central nervous systems, also having hormonal properties." [GOC:ai] synonym: "5-hydroxytryptamine binding" EXACT [] is_a: GO:0043169 ! cation binding is_a: GO:0043176 ! amine binding is_a: GO:1901363 ! heterocyclic compound binding intersection_of: GO:0005488 ! binding intersection_of: RO:0004009 CHEBI:350546 ! has primary input relationship: RO:0004009 CHEBI:350546 ! has primary input [Term] id: GO:0051379 name: epinephrine binding namespace: molecular_function def: "Binding to epinephrine, a hormone produced by the medulla of the adrenal glands that increases heart activity, improves the power and prolongs the action of muscles, and increases the rate and depth of breathing. It is synthesized by the methylation of norepinephrine." [GOC:ai] synonym: "adrenaline binding" EXACT [] is_a: GO:0042562 ! hormone binding is_a: GO:0043169 ! cation binding is_a: GO:1901338 ! catecholamine binding intersection_of: GO:0005488 ! binding intersection_of: RO:0004009 CHEBI:71406 ! has primary input relationship: RO:0004009 CHEBI:71406 ! has primary input property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/21211" xsd:anyURI [Term] id: GO:0051380 name: norepinephrine binding namespace: molecular_function def: "Binding to norepinephrine, (3,4-dihydroxyphenyl-2-aminoethanol), a hormone secreted by the adrenal medulla and a neurotransmitter in the sympathetic peripheral nervous system and in some tracts of the CNS. It is also the biosynthetic precursor of epinephrine." [GOC:ai] synonym: "noradrenaline binding" EXACT [] is_a: GO:0043169 ! cation binding is_a: GO:1901338 ! catecholamine binding intersection_of: GO:0005488 ! binding intersection_of: RO:0004009 CHEBI:72587 ! has primary input relationship: RO:0004009 CHEBI:72587 ! has primary input [Term] id: GO:0051381 name: histamine binding namespace: molecular_function def: "Binding to histamine, a physiologically active amine, found in plant and animal tissue and released from mast cells as part of an allergic reaction in humans." [GOC:ai] is_a: GO:0043169 ! cation binding is_a: GO:1901363 ! heterocyclic compound binding intersection_of: GO:0005488 ! binding intersection_of: RO:0004009 CHEBI:58432 ! has primary input relationship: RO:0004009 CHEBI:58432 ! has primary input [Term] id: GO:0051384 name: response to glucocorticoid namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucocorticoid stimulus. Glucocorticoids are hormonal C21 corticosteroids synthesized from cholesterol with the ability to bind with the cortisol receptor and trigger similar effects. Glucocorticoids act primarily on carbohydrate and protein metabolism, and have anti-inflammatory effects." [GOC:ai, PMID:9884123] synonym: "response to glucocorticoid stimulus" EXACT [GOC:dos] is_a: GO:0031960 ! response to corticosteroid intersection_of: GO:0050896 ! response to stimulus intersection_of: RO:0004009 CHEBI:24261 ! has primary input relationship: RO:0004009 CHEBI:24261 ! has primary input property_value: RO:0002161 NCBITaxon:4751 [Term] id: GO:0051385 name: response to mineralocorticoid namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mineralocorticoid stimulus. Mineralocorticoids are hormonal C21 corticosteroids synthesized from cholesterol and characterized by their similarity to aldosterone. Mineralocorticoids act primarily on water and electrolyte balance." [GOC:ai, PMID:9884123] synonym: "response to mineralocorticoid stimulus" EXACT [GOC:dos] is_a: GO:0031960 ! response to corticosteroid intersection_of: GO:0050896 ! response to stimulus intersection_of: RO:0004009 CHEBI:25354 ! has primary input relationship: RO:0004009 CHEBI:25354 ! has primary input property_value: RO:0002161 NCBITaxon:4751 [Term] id: GO:0051402 name: neuron apoptotic process namespace: biological_process def: "Any apoptotic process in a neuron, the basic cellular unit of nervous tissue. Each neuron consists of a body, an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the nervous system." [CL:0000540, GOC:mtg_apoptosis] synonym: "apoptosis of neuronal cells" EXACT [] synonym: "apoptosis of neurons" EXACT [] synonym: "neuron apoptosis" NARROW [] synonym: "neuron programmed cell death by apoptosis" EXACT [] synonym: "neuronal cell apoptosis" EXACT [] synonym: "neuronal cell programmed cell death by apoptosis" EXACT [] synonym: "programmed cell death of neuronal cells by apoptosis" EXACT [] synonym: "programmed cell death of neurons by apoptosis" EXACT [] synonym: "programmed cell death, neuronal cells" EXACT [] synonym: "programmed cell death, neurons" EXACT [] is_a: GO:0006915 ! apoptotic process intersection_of: GO:0006915 ! apoptotic process intersection_of: BFO:0000066 CL:0000540 ! occurs in neuron relationship: BFO:0000066 CL:0000540 ! occurs in neuron property_value: RO:0002161 NCBITaxon:4896 [Term] id: GO:0051410 name: detoxification of nitrogen compound namespace: biological_process def: "Any process that reduces or removes the toxicity of nitrogenous compounds which are dangerous or toxic. This includes the aerobic conversion of toxic compounds to harmless substances." [GOC:ai] synonym: "detoxification of nitrogenous compound" EXACT [] synonym: "nitric oxide (NO) detoxification" NARROW [] is_a: BFO:0000003 is_a: GO:0098754 ! detoxification intersection_of: GO:0098754 ! detoxification intersection_of: RO:0004009 CHEBI:51143 ! has primary input relationship: BFO:0000050 GO:1901698 ! part of response to nitrogen compound relationship: RO:0004009 CHEBI:51143 ! has primary input [Term] id: GO:0051418 name: microtubule nucleation by microtubule organizing center namespace: biological_process def: "The 'de novo' formation of a microtubule, mediated by the microtubule organizing center." [GOC:ai] synonym: "microtubule nucleation by microtubule organising centre" EXACT [] synonym: "microtubule nucleation by MTOC" EXACT [] synonym: "microtubule organizing center-mediated microtubule nucleation" EXACT [] synonym: "MTOC-mediated microtubule nucleation" EXACT [] is_a: GO:0007020 ! microtubule nucleation intersection_of: GO:0007020 ! microtubule nucleation intersection_of: RO:0002608 GO:0005815 ! process has causal agent microtubule organizing center relationship: RO:0002608 GO:0005815 ! process has causal agent microtubule organizing center [Term] id: GO:0051445 name: regulation of meiotic cell cycle namespace: biological_process def: "Any process that modulates the rate or extent of progression through the meiotic cell cycle." [GOC:ai, GOC:dph, GOC:tb] synonym: "meiotic cell cycle modulation" EXACT [] synonym: "meiotic cell cycle regulation" EXACT [] synonym: "meiotic cell cycle regulator" RELATED [] synonym: "modulation of meiotic cell cycle progression" EXACT [] synonym: "regulation of meiotic cell cycle progression" EXACT [] synonym: "regulation of progression through meiotic cell cycle" EXACT [GOC:dph, GOC:tb] is_a: GO:0051726 ! regulation of cell cycle is_a: GO:2000241 ! regulation of reproductive process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0051321 ! regulates meiotic cell cycle relationship: RO:0002211 GO:0051321 ! regulates meiotic cell cycle [Term] id: GO:0051446 name: positive regulation of meiotic cell cycle namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of progression through the meiotic cell cycle." [GOC:ai, GOC:dph, GOC:tb] synonym: "activation of progression through meiotic cell cycle" NARROW [] synonym: "positive regulation of meiotic cell cycle progression" EXACT [] synonym: "positive regulation of progression through meiotic cell cycle" EXACT [GOC:dph, GOC:tb] synonym: "stimulation of progression through meiotic cell cycle" NARROW [] synonym: "up regulation of progression through meiotic cell cycle" EXACT [] synonym: "up-regulation of progression through meiotic cell cycle" EXACT [] synonym: "upregulation of progression through meiotic cell cycle" EXACT [] is_a: GO:0045787 ! positive regulation of cell cycle is_a: GO:0051445 ! regulation of meiotic cell cycle is_a: GO:2000243 ! positive regulation of reproductive process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0051321 ! positively regulates meiotic cell cycle relationship: RO:0002213 GO:0051321 ! positively regulates meiotic cell cycle [Term] id: GO:0051447 name: negative regulation of meiotic cell cycle namespace: biological_process def: "Any process that stops, prevents or reduces the rate or extent of progression through the meiotic cell cycle." [GOC:ai, GOC:dph, GOC:tb] synonym: "down regulation of progression through meiotic cell cycle" EXACT [] synonym: "down-regulation of progression through meiotic cell cycle" EXACT [] synonym: "downregulation of progression through meiotic cell cycle" EXACT [] synonym: "inhibition of progression through meiotic cell cycle" NARROW [] synonym: "negative regulation of meiotic cell cycle progression" EXACT [] synonym: "negative regulation of progression through meiotic cell cycle" EXACT [GOC:dph, GOC:tb] is_a: GO:0045786 ! negative regulation of cell cycle is_a: GO:0051445 ! regulation of meiotic cell cycle is_a: GO:2000242 ! negative regulation of reproductive process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0051321 ! negatively regulates meiotic cell cycle relationship: RO:0002212 GO:0051321 ! negatively regulates meiotic cell cycle [Term] id: GO:0051450 name: myoblast proliferation namespace: biological_process def: "The multiplication or reproduction of myoblasts, resulting in the expansion of a myoblast cell population. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers." [CL:0000056, GOC:ai, GOC:mtg_muscle] is_a: BFO:0000003 is_a: GO:0008283 ! cell population proliferation intersection_of: GO:0008283 ! cell population proliferation intersection_of: RO:0012003 CL:0000056 ! acts on population of myoblast relationship: RO:0012003 CL:0000056 ! acts on population of myoblast property_value: RO:0002161 NCBITaxon:4751 [Term] id: GO:0051451 name: myoblast migration namespace: biological_process def: "The orderly movement of a myoblast from one site to another, often during the development of a multicellular organism. A myoblast is a cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers." [CL:0000056, GOC:ai, GOC:mtg_muscle] is_a: GO:0014812 ! muscle cell migration intersection_of: GO:0016477 ! cell migration intersection_of: RO:0002565 CL:0000056 ! results in movement of myoblast relationship: RO:0002565 CL:0000056 ! results in movement of myoblast property_value: RO:0002161 NCBITaxon:4890 [Term] id: GO:0051457 name: maintenance of protein location in nucleus namespace: biological_process def: "Any process in which a protein is maintained in the nucleus and prevented from moving elsewhere. These include sequestration within the nucleus, protein stabilization to prevent transport elsewhere and the active retrieval of proteins that escape the nucleus." [GOC:ai] synonym: "maintenance of nuclear protein localization" EXACT [] synonym: "maintenance of protein localization in nucleus" RELATED [GOC:dph, GOC:tb] synonym: "maintenance of protein location in cell nucleus" EXACT [] synonym: "nuclear protein retention" NARROW [] synonym: "nuclear protein sequestering" NARROW [] synonym: "nuclear protein sequestration" NARROW [] synonym: "protein retention in nucleus" NARROW [] synonym: "protein sequestration in nucleus" NARROW [] synonym: "protein storage in nucleus" NARROW [] synonym: "protein-nuclear retention" NARROW [] synonym: "sequestration of protein in nucleus" NARROW [] synonym: "storage of protein in nucleus" NARROW [] is_a: GO:0072595 ! maintenance of protein localization in organelle intersection_of: GO:0045185 ! maintenance of protein location intersection_of: BFO:0000066 GO:0005634 ! occurs in nucleus relationship: BFO:0000050 GO:0034504 ! part of protein localization to nucleus relationship: BFO:0000066 GO:0005634 ! occurs in nucleus relationship: RO:0002162 NCBITaxon:2759 ! in taxon Eukaryota [Term] id: GO:0051458 name: corticotropin secretion namespace: biological_process def: "The regulated release of corticotropin by a cell. Corticotropin hormone is a polypeptide hormone synthesized and secreted from corticotropes in the anterior lobe of the pituitary gland in response to corticotropin-releasing hormone (CRH) released by the hypothalamus." [GOC:cjm, PMID:11027914] synonym: "ACTH secretion" EXACT [] synonym: "adrenocorticotropic hormone secretion" EXACT [] synonym: "adrenocorticotropin secretion" RELATED [GOC:dph, GOC:tb] synonym: "adrenotropic hormone secretion" EXACT [] synonym: "adrenotropin secretion" EXACT [] synonym: "corticotropic hormone secretion" EXACT [] is_a: GO:0030072 ! peptide hormone secretion is_a: GO:0060986 ! endocrine hormone secretion intersection_of: GO:0046903 ! secretion intersection_of: RO:0004009 CHEBI:3892 ! has primary input relationship: RO:0004009 CHEBI:3892 ! has primary input property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0051459 name: regulation of corticotropin secretion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the regulated release of corticotropic hormone from a cell." [GOC:ai, GOC:dph] synonym: "regulation of ACTH secretion" EXACT [] synonym: "regulation of adrenocorticotropic hormone secretion" EXACT [GOC:dph] synonym: "regulation of adrenocorticotropin secretion" EXACT [] synonym: "regulation of adrenotropin hormone secretion" EXACT [] synonym: "regulation of adrenotropin secretion" EXACT [] synonym: "regulation of corticotropic hormone secretion" EXACT [] is_a: GO:0044060 ! regulation of endocrine process is_a: GO:0090276 ! regulation of peptide hormone secretion intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0051458 ! regulates corticotropin secretion relationship: RO:0002211 GO:0051458 ! regulates corticotropin secretion property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0051460 name: negative regulation of corticotropin secretion namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of corticotropic hormone from a cell." [GOC:ai] synonym: "down regulation of adrenocorticotropin secretion" EXACT [] synonym: "down-regulation of adrenocorticotropin secretion" EXACT [] synonym: "downregulation of adrenocorticotropin secretion" EXACT [] synonym: "inhibition of adrenocorticotropin secretion" NARROW [] synonym: "negative regulation of ACTH secretion" EXACT [] synonym: "negative regulation of adrenocorticotropic hormone secretion" EXACT [] synonym: "negative regulation of adrenocorticotropin secretion" EXACT [] synonym: "negative regulation of adrenotropic hormone secretion" EXACT [] synonym: "negative regulation of adrenotropin secretion" EXACT [] synonym: "negative regulation of corticotropic hormone secretion" EXACT [] is_a: GO:0051241 ! negative regulation of multicellular organismal process is_a: GO:0051459 ! regulation of corticotropin secretion is_a: GO:0090278 ! negative regulation of peptide hormone secretion intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0051458 ! negatively regulates corticotropin secretion relationship: RO:0002212 GO:0051458 ! negatively regulates corticotropin secretion property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0051461 name: positive regulation of corticotropin secretion namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the regulated release of corticotropin hormone from a cell." [GOC:ai] synonym: "activation of adrenocorticotropin secretion" NARROW [] synonym: "positive regulation of ACTH secretion" EXACT [] synonym: "positive regulation of adrenocorticotropic hormone secretion" EXACT [] synonym: "positive regulation of adrenocorticotropin secretion" EXACT [GOC:dph, GOC:tb] synonym: "positive regulation of adrenotropic hormone secretion" EXACT [] synonym: "positive regulation of adrenotropin secretion" EXACT [] synonym: "positive regulation of corticotropic hormone secretion" EXACT [] synonym: "stimulation of adrenocorticotropin secretion" NARROW [] synonym: "up regulation of adrenocorticotropin secretion" EXACT [] synonym: "up-regulation of adrenocorticotropin secretion" EXACT [] synonym: "upregulation of adrenocorticotropin secretion" EXACT [] is_a: GO:0051240 ! positive regulation of multicellular organismal process is_a: GO:0051459 ! regulation of corticotropin secretion is_a: GO:0090277 ! positive regulation of peptide hormone secretion intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0051458 ! positively regulates corticotropin secretion relationship: RO:0002213 GO:0051458 ! positively regulates corticotropin secretion property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0051469 name: vesicle fusion with vacuole namespace: biological_process def: "The joining of the lipid bilayer membrane around a vesicle with the lipid bilayer membrane around the vacuole." [GOC:ai] synonym: "heterotypic vacuole fusion (non-autophagic)" RELATED [] synonym: "heterotypic vacuole fusion, non-autophagic" RELATED [] is_a: GO:0006906 ! vesicle fusion is_a: GO:0097576 ! vacuole fusion intersection_of: GO:0009987 ! cellular process intersection_of: RO:0012008 GO:0005773 ! results in fusion of vacuole intersection_of: RO:0012008 GO:0031982 ! results in fusion of vesicle relationship: RO:0012008 GO:0031982 ! results in fusion of vesicle [Term] id: GO:0051493 name: regulation of cytoskeleton organization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures." [GOC:ai] synonym: "regulation of cytoskeleton organisation" EXACT [GOC:mah] synonym: "regulation of cytoskeleton organization and biogenesis" RELATED [GOC:mah] is_a: GO:0033043 ! regulation of organelle organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0007010 ! regulates cytoskeleton organization relationship: RO:0002211 GO:0007010 ! regulates cytoskeleton organization [Term] id: GO:0051494 name: negative regulation of cytoskeleton organization namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures." [GOC:ai] synonym: "down regulation of cytoskeleton organization" EXACT [] synonym: "down-regulation of cytoskeleton organization" EXACT [] synonym: "downregulation of cytoskeleton organization" EXACT [] synonym: "inhibition of cytoskeleton organization" NARROW [] synonym: "negative regulation of cytoskeleton organisation" EXACT [GOC:mah] synonym: "negative regulation of cytoskeleton organization and biogenesis" RELATED [GOC:mah] is_a: GO:0010639 ! negative regulation of organelle organization is_a: GO:0051493 ! regulation of cytoskeleton organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0007010 ! negatively regulates cytoskeleton organization relationship: RO:0002212 GO:0007010 ! negatively regulates cytoskeleton organization [Term] id: GO:0051495 name: positive regulation of cytoskeleton organization namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures." [GOC:ai] synonym: "activation of cytoskeleton organization" NARROW [] synonym: "positive regulation of cytoskeleton organisation" EXACT [GOC:mah] synonym: "positive regulation of cytoskeleton organization and biogenesis" RELATED [GOC:mah] synonym: "stimulation of cytoskeleton organization" NARROW [] synonym: "up regulation of cytoskeleton organization" EXACT [] synonym: "up-regulation of cytoskeleton organization" EXACT [] synonym: "upregulation of cytoskeleton organization" EXACT [] is_a: GO:0010638 ! positive regulation of organelle organization is_a: GO:0051493 ! regulation of cytoskeleton organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0007010 ! positively regulates cytoskeleton organization relationship: RO:0002213 GO:0007010 ! positively regulates cytoskeleton organization [Term] id: GO:0051503 name: adenine nucleotide transport namespace: biological_process def: "The directed movement of adenine nucleotides, ATP, ADP, and/or AMP, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] is_a: GO:0015865 ! purine nucleotide transport intersection_of: GO:0006810 ! transport intersection_of: RO:0004009 CHEBI:61293 ! has primary input relationship: RO:0004009 CHEBI:61293 ! has primary input [Term] id: GO:0051546 name: keratinocyte migration namespace: biological_process def: "The directed movement of a keratinocyte, epidermal cells which synthesize keratin, from one site to another." [ISBN:0721662544] is_a: GO:0010631 ! epithelial cell migration intersection_of: GO:0016477 ! cell migration intersection_of: RO:0002565 CL:0000312 ! results in movement of keratinocyte relationship: RO:0002565 CL:0000312 ! results in movement of keratinocyte property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4890 property_value: RO:0002161 NCBITaxon:6656 [Term] id: GO:0051547 name: regulation of keratinocyte migration namespace: biological_process def: "Any process that modulates the frequency, rate or extent of keratinocyte migration." [GOC:ai] is_a: GO:0010632 ! regulation of epithelial cell migration intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0051546 ! regulates keratinocyte migration relationship: RO:0002211 GO:0051546 ! regulates keratinocyte migration property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:451864 property_value: RO:0002161 NCBITaxon:6656 [Term] id: GO:0051548 name: negative regulation of keratinocyte migration namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of keratinocyte migration." [GOC:ai] synonym: "down regulation of keratinocyte migration" EXACT [] synonym: "down-regulation of keratinocyte migration" EXACT [] synonym: "downregulation of keratinocyte migration" EXACT [] synonym: "inhibition of keratinocyte migration" NARROW [] is_a: GO:0010633 ! negative regulation of epithelial cell migration is_a: GO:0051547 ! regulation of keratinocyte migration intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0051546 ! negatively regulates keratinocyte migration relationship: RO:0002212 GO:0051546 ! negatively regulates keratinocyte migration property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:451864 property_value: RO:0002161 NCBITaxon:6656 [Term] id: GO:0051549 name: positive regulation of keratinocyte migration namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of keratinocyte migration." [GOC:ai] synonym: "activation of keratinocyte migration" NARROW [] synonym: "stimulation of keratinocyte migration" NARROW [] synonym: "up regulation of keratinocyte migration" EXACT [] synonym: "up-regulation of keratinocyte migration" EXACT [] synonym: "upregulation of keratinocyte migration" EXACT [] is_a: GO:0010634 ! positive regulation of epithelial cell migration is_a: GO:0051547 ! regulation of keratinocyte migration intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0051546 ! positively regulates keratinocyte migration relationship: RO:0002213 GO:0051546 ! positively regulates keratinocyte migration property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:451864 property_value: RO:0002161 NCBITaxon:6656 [Term] id: GO:0051560 name: mitochondrial calcium ion homeostasis namespace: biological_process def: "Any process involved in the maintenance of an internal steady state of calcium ions within the cytoplasm of a cell or between mitochondria and their surroundings." [GOC:ai, GOC:mah] synonym: "calcium ion homeostasis in mitochondria" EXACT [] synonym: "calcium ion homeostasis in mitochondrion" EXACT [] synonym: "mitochondrial calcium ion concentration regulation" EXACT [] synonym: "regulation of calcium ion concentration in mitochondria" EXACT [] synonym: "regulation of calcium ion concentration in mitochondrion" EXACT [] synonym: "regulation of mitochondrial calcium ion concentration" EXACT [] is_a: GO:0006874 ! intracellular calcium ion homeostasis intersection_of: GO:0055074 ! calcium ion homeostasis intersection_of: BFO:0000066 GO:0005739 ! occurs in mitochondrion relationship: BFO:0000066 GO:0005739 ! occurs in mitochondrion relationship: RO:0002162 NCBITaxon:2759 ! in taxon Eukaryota [Term] id: GO:0051580 name: regulation of neurotransmitter uptake namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the directed movement of a neurotransmitter into a neuron or glial cell." [GOC:ai] subset: goslim_synapse synonym: "regulation of neurotransmitter import" EXACT [GOC:dph, GOC:tb] synonym: "regulation of neurotransmitter reuptake" EXACT [] is_a: GO:0051588 ! regulation of neurotransmitter transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0001504 ! regulates neurotransmitter uptake relationship: RO:0002211 GO:0001504 ! regulates neurotransmitter uptake [Term] id: GO:0051581 name: negative regulation of neurotransmitter uptake namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of a neurotransmitter into a neuron or glial cell." [GOC:ai] synonym: "down regulation of neurotransmitter uptake" EXACT [] synonym: "down-regulation of neurotransmitter uptake" EXACT [] synonym: "downregulation of neurotransmitter uptake" EXACT [] synonym: "negative regulation of neurotransmitter import" EXACT [GOC:dph, GOC:tb] is_a: GO:0051580 ! regulation of neurotransmitter uptake is_a: GO:0051589 ! negative regulation of neurotransmitter transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0001504 ! negatively regulates neurotransmitter uptake relationship: RO:0002212 GO:0001504 ! negatively regulates neurotransmitter uptake [Term] id: GO:0051582 name: positive regulation of neurotransmitter uptake namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the directed movement of a neurotransmitter into a neuron or glial cell." [GOC:ai] synonym: "activation of neurotransmitter uptake" NARROW [] synonym: "positive regulation of neurotransmitter import" EXACT [GOC:dph, GOC:tb] synonym: "stimulation of neurotransmitter uptake" NARROW [] synonym: "up regulation of neurotransmitter uptake" EXACT [] synonym: "up-regulation of neurotransmitter uptake" EXACT [] synonym: "upregulation of neurotransmitter uptake" EXACT [] is_a: GO:0051580 ! regulation of neurotransmitter uptake is_a: GO:0051590 ! positive regulation of neurotransmitter transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0001504 ! positively regulates neurotransmitter uptake relationship: RO:0002213 GO:0001504 ! positively regulates neurotransmitter uptake [Term] id: GO:0051588 name: regulation of neurotransmitter transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the directed movement of a neurotransmitter into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] is_a: GO:0051049 ! regulation of transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0006836 ! regulates neurotransmitter transport relationship: RO:0002211 GO:0006836 ! regulates neurotransmitter transport [Term] id: GO:0051589 name: negative regulation of neurotransmitter transport namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of a neurotransmitter into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] synonym: "down regulation of neurotransmitter transport" EXACT [] synonym: "down-regulation of neurotransmitter transport" EXACT [] synonym: "downregulation of neurotransmitter transport" EXACT [] synonym: "inhibition of neurotransmitter transport" NARROW [] is_a: GO:0051051 ! negative regulation of transport is_a: GO:0051588 ! regulation of neurotransmitter transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0006836 ! negatively regulates neurotransmitter transport relationship: RO:0002212 GO:0006836 ! negatively regulates neurotransmitter transport [Term] id: GO:0051590 name: positive regulation of neurotransmitter transport namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the directed movement of a neurotransmitter into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] synonym: "activation of neurotransmitter transport" NARROW [] synonym: "stimulation of neurotransmitter transport" NARROW [] synonym: "up regulation of neurotransmitter transport" EXACT [] synonym: "up-regulation of neurotransmitter transport" EXACT [] synonym: "upregulation of neurotransmitter transport" EXACT [] is_a: GO:0051050 ! positive regulation of transport is_a: GO:0051588 ! regulation of neurotransmitter transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0006836 ! positively regulates neurotransmitter transport relationship: RO:0002213 GO:0006836 ! positively regulates neurotransmitter transport [Term] id: GO:0051592 name: response to calcium ion namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a calcium ion stimulus." [GOC:ai] synonym: "response to Ca2+ ion" EXACT [] is_a: GO:0010038 ! response to metal ion intersection_of: GO:0050896 ! response to stimulus intersection_of: RO:0004009 CHEBI:29108 ! has primary input relationship: RO:0004009 CHEBI:29108 ! has primary input [Term] id: GO:0051602 name: response to electrical stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an electrical stimulus." [GOC:ai] synonym: "response to electricity" RELATED [] is_a: GO:0009628 ! response to abiotic stimulus [Term] id: GO:0051603 name: proteolysis involved in protein catabolic process namespace: biological_process def: "The hydrolysis of a peptide bond or bonds within a protein as part of the chemical reactions and pathways resulting in the breakdown of a protein by individual cells." [GOC:ai, GOC:dph, GOC:tb] subset: goslim_yeast synonym: "peptidolysis during cellular protein catabolic process" RELATED [] synonym: "peptidolysis during cellular protein catabolism" RELATED [] synonym: "peptidolysis involved in cellular protein catabolic process" EXACT [] synonym: "peptidolysis involved in cellular protein catabolism" EXACT [] synonym: "proteolysis during cellular protein catabolic process" RELATED [] synonym: "proteolysis during cellular protein catabolism" RELATED [] synonym: "proteolysis involved in cellular protein catabolic process" EXACT [] is_a: GO:0006508 ! proteolysis intersection_of: GO:0006508 ! proteolysis intersection_of: BFO:0000050 GO:0030163 ! part of protein catabolic process relationship: BFO:0000050 GO:0030163 ! part of protein catabolic process property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/23112" xsd:anyURI [Term] id: GO:0051604 name: protein maturation namespace: biological_process def: "Any process leading to the attainment of the full functional capacity of a protein." [GOC:ai] subset: goslim_chembl subset: goslim_drosophila subset: goslim_generic subset: goslim_pir subset: goslim_pombe subset: goslim_prokaryote subset: goslim_yeast is_a: GO:0019538 ! protein metabolic process relationship: BFO:0000050 GO:0010467 ! part of gene expression [Term] id: GO:0051606 name: detection of stimulus namespace: biological_process def: "The series of events in which a stimulus is received by a cell or organism and converted into a molecular signal." [GOC:add, GOC:ai, GOC:dph, GOC:mah] subset: goslim_pir synonym: "perception of stimulus" RELATED [] synonym: "stimulus detection" EXACT [] synonym: "stimulus sensing" RELATED [] is_a: GO:0050896 ! response to stimulus [Term] id: GO:0051608 name: histamine transport namespace: biological_process def: "The directed movement of histamine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Histamine is a physiologically active amine, found in plant and animal tissue and released from mast cells as part of an allergic reaction in humans." [GOC:ai] is_a: GO:0071705 ! nitrogen compound transport intersection_of: GO:0006810 ! transport intersection_of: RO:0004009 CHEBI:58432 ! has primary input relationship: RO:0004009 CHEBI:58432 ! has primary input [Term] id: GO:0051615 name: histamine uptake namespace: biological_process def: "The directed movement of histamine into a cell, typically presynaptic neurons or glial cells. Histamine is a physiologically active amine, found in plant and animal tissue and released from mast cells as part of an allergic reaction in humans." [GOC:ai] synonym: "histamine import" EXACT [GOC:dph, GOC:tb] is_a: GO:0001504 ! neurotransmitter uptake is_a: GO:0051608 ! histamine transport intersection_of: GO:0006810 ! transport intersection_of: RO:0002338 GO:0005576 ! has target start location extracellular region intersection_of: RO:0002339 GO:0005829 ! has target end location cytosol intersection_of: RO:0004009 CHEBI:58432 ! has primary input [Term] id: GO:0051616 name: regulation of histamine uptake namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the directed movement of the neurotransmitter histamine into a cell." [GOC:ai] synonym: "regulation of histamine import" EXACT [GOC:dph, GOC:tb] is_a: GO:0051580 ! regulation of neurotransmitter uptake intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0051615 ! regulates histamine uptake relationship: RO:0002211 GO:0051615 ! regulates histamine uptake [Term] id: GO:0051617 name: negative regulation of histamine uptake namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of histamine into a cell." [GOC:ai] synonym: "down regulation of histamine uptake" EXACT [] synonym: "down-regulation of histamine uptake" EXACT [] synonym: "downregulation of histamine uptake" EXACT [] synonym: "negative regulation of histamine import" EXACT [GOC:dph, GOC:tb] is_a: GO:0051581 ! negative regulation of neurotransmitter uptake is_a: GO:0051616 ! regulation of histamine uptake intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0051615 ! negatively regulates histamine uptake relationship: RO:0002212 GO:0051615 ! negatively regulates histamine uptake [Term] id: GO:0051618 name: positive regulation of histamine uptake namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the directed movement of histamine into a cell." [GOC:ai] synonym: "activation of histamine uptake" NARROW [] synonym: "positive regulation of histamine import" EXACT [GOC:dph, GOC:tb] synonym: "stimulation of histamine uptake" NARROW [] synonym: "up regulation of histamine uptake" EXACT [] synonym: "up-regulation of histamine uptake" EXACT [] synonym: "upregulation of histamine uptake" EXACT [] is_a: GO:0051582 ! positive regulation of neurotransmitter uptake is_a: GO:0051616 ! regulation of histamine uptake intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0051615 ! positively regulates histamine uptake relationship: RO:0002213 GO:0051615 ! positively regulates histamine uptake [Term] id: GO:0051620 name: norepinephrine uptake namespace: biological_process def: "The directed movement of norepinephrine into a cell, typically presynaptic neurons or glial cells. Norepinephrine (3,4-dihydroxyphenyl-2-aminoethanol) is a hormone secreted by the adrenal medulla and a neurotransmitter in the sympathetic peripheral nervous system and in some tracts of the CNS. It is also the biosynthetic precursor of epinephrine." [GOC:ai] synonym: "levarterenol reuptake" EXACT [] synonym: "levarterenol uptake" EXACT [] synonym: "noradrenaline reuptake" EXACT [] synonym: "noradrenaline uptake" EXACT [] synonym: "norepinephrine import" EXACT [GOC:dph, GOC:tb] synonym: "norepinephrine reuptake" EXACT [] is_a: GO:0015874 ! norepinephrine transport is_a: GO:0090493 ! catecholamine uptake intersection_of: GO:0006810 ! transport intersection_of: RO:0002338 GO:0005576 ! has target start location extracellular region intersection_of: RO:0002339 GO:0005622 ! has target end location intracellular anatomical structure intersection_of: RO:0004009 CHEBI:72587 ! has primary input [Term] id: GO:0051621 name: regulation of norepinephrine uptake namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the directed movement of the neurotransmitter norepinephrine into a cell." [GOC:ai] synonym: "regulation of levarterenol uptake" EXACT [] synonym: "regulation of noradrenaline uptake" EXACT [] synonym: "regulation of norepinephrine import" EXACT [GOC:dph, GOC:tb] is_a: GO:0051049 ! regulation of transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0051620 ! regulates norepinephrine uptake relationship: RO:0002211 GO:0051620 ! regulates norepinephrine uptake [Term] id: GO:0051622 name: negative regulation of norepinephrine uptake namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of norepinephrine into a cell." [GOC:ai] synonym: "down regulation of norepinephrine uptake" EXACT [] synonym: "down-regulation of norepinephrine uptake" EXACT [] synonym: "downregulation of norepinephrine uptake" EXACT [] synonym: "negative regulation of levarterenol uptake" EXACT [] synonym: "negative regulation of noradrenaline uptake" EXACT [] synonym: "negative regulation of norepinephrine import" EXACT [GOC:dph, GOC:tb] is_a: GO:0051051 ! negative regulation of transport is_a: GO:0051621 ! regulation of norepinephrine uptake intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0051620 ! negatively regulates norepinephrine uptake relationship: RO:0002212 GO:0051620 ! negatively regulates norepinephrine uptake [Term] id: GO:0051623 name: positive regulation of norepinephrine uptake namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the directed movement of norepinephrine into a cell." [GOC:ai] synonym: "activation of norepinephrine uptake" NARROW [] synonym: "positive regulation of levarterenol uptake" EXACT [] synonym: "positive regulation of noradrenaline uptake" EXACT [] synonym: "positive regulation of norepinephrine import" EXACT [GOC:dph, GOC:tb] synonym: "stimulation of norepinephrine uptake" NARROW [] synonym: "up regulation of norepinephrine uptake" EXACT [] synonym: "up-regulation of norepinephrine uptake" EXACT [] synonym: "upregulation of norepinephrine uptake" EXACT [] is_a: GO:0051050 ! positive regulation of transport is_a: GO:0051621 ! regulation of norepinephrine uptake intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0051620 ! positively regulates norepinephrine uptake relationship: RO:0002213 GO:0051620 ! positively regulates norepinephrine uptake [Term] id: GO:0051630 name: acetylcholine uptake namespace: biological_process def: "The directed movement of acetylcholine into a cell, typically presynaptic neurons or glial cells. Acetylcholine is a major neurotransmitter and neuromodulator both in the central and peripheral nervous systems. It also acts as a paracrine signal in various non-neural tissues." [GOC:ai] synonym: "acetylcholine import" EXACT [GOC:dph, GOC:tb] is_a: GO:0015870 ! acetylcholine transport intersection_of: GO:0006810 ! transport intersection_of: RO:0002338 GO:0005576 ! has target start location extracellular region intersection_of: RO:0002339 GO:0005622 ! has target end location intracellular anatomical structure intersection_of: RO:0004009 CHEBI:15355 ! has primary input relationship: RO:0002338 GO:0005576 ! has target start location extracellular region relationship: RO:0002339 GO:0005622 ! has target end location intracellular anatomical structure [Term] id: GO:0051631 name: regulation of acetylcholine uptake namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the directed movement of the neurotransmitter acetylcholine into a cell." [GOC:ai] synonym: "regulation of acetylcholine import" EXACT [GOC:dph, GOC:tb] is_a: GO:0051952 ! regulation of amine transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0051630 ! regulates acetylcholine uptake relationship: RO:0002211 GO:0051630 ! regulates acetylcholine uptake [Term] id: GO:0051632 name: negative regulation of acetylcholine uptake namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of acetylcholine into a cell." [GOC:ai] synonym: "down regulation of acetylcholine uptake" EXACT [] synonym: "down-regulation of acetylcholine uptake" EXACT [] synonym: "downregulation of acetylcholine uptake" EXACT [] synonym: "negative regulation of acetylcholine import" EXACT [GOC:dph, GOC:tb] is_a: GO:0051631 ! regulation of acetylcholine uptake is_a: GO:0051953 ! negative regulation of amine transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0051630 ! negatively regulates acetylcholine uptake relationship: RO:0002212 GO:0051630 ! negatively regulates acetylcholine uptake [Term] id: GO:0051633 name: positive regulation of acetylcholine uptake namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the directed movement of acetylcholine into a cell." [GOC:ai] synonym: "activation of acetylcholine uptake" NARROW [] synonym: "positive regulation of acetylcholine import" EXACT [GOC:dph, GOC:tb] synonym: "stimulation of acetylcholine uptake" NARROW [] synonym: "up regulation of acetylcholine uptake" EXACT [] synonym: "up-regulation of acetylcholine uptake" EXACT [] synonym: "upregulation of acetylcholine uptake" EXACT [] is_a: GO:0051631 ! regulation of acetylcholine uptake is_a: GO:0051954 ! positive regulation of amine transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0051630 ! positively regulates acetylcholine uptake relationship: RO:0002213 GO:0051630 ! positively regulates acetylcholine uptake [Term] id: GO:0051640 name: organelle localization namespace: biological_process def: "Any process in which an organelle is transported to, and/or maintained in, a specific location." [GOC:ai] subset: gocheck_do_not_annotate subset: goslim_pir synonym: "establishment and maintenance of organelle localization" EXACT [] synonym: "organelle localisation" EXACT [GOC:mah] is_a: BFO:0000003 is_a: GO:0051179 ! localization intersection_of: GO:0051179 ! localization intersection_of: RO:0004009 GO:0043226 ! has primary input organelle relationship: RO:0002162 NCBITaxon:2759 ! in taxon Eukaryota relationship: RO:0004009 GO:0043226 ! has primary input organelle property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/19809" xsd:anyURI [Term] id: GO:0051641 name: cellular localization namespace: biological_process def: "A cellular localization process whereby a substance or cellular entity, such as a protein complex or organelle, is transported to, and/or maintained in, a specific location within a cell including the localization of substances or cellular entities to the cell membrane." [GOC:tb, GOC:vw] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_annotate subset: goslim_pir synonym: "cellular localisation" EXACT [GOC:mah] synonym: "establishment and maintenance of cellular localization" EXACT [] synonym: "establishment and maintenance of localization in cell or cell membrane" EXACT [] synonym: "intracellular localization" NARROW [] synonym: "localization within cell" NARROW [] synonym: "single organism cellular localization" EXACT [GOC:TermGenie] synonym: "single-organism cellular localization" RELATED [] is_a: GO:0009987 ! cellular process is_a: GO:0051179 ! localization property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/27189" xsd:anyURI creation_date: 2013-12-18T14:04:32Z [Term] id: GO:0051644 name: plastid localization namespace: biological_process def: "Any process in which a plastid is transported to, and/or maintained in, a specific location within the cell." [GOC:ai] synonym: "establishment and maintenance of plastid localization" EXACT [] synonym: "plastid localisation" EXACT [GOC:mah] is_a: GO:0051640 ! organelle localization intersection_of: GO:0051179 ! localization intersection_of: RO:0004009 GO:0009536 ! has primary input plastid relationship: RO:0004009 GO:0009536 ! has primary input plastid property_value: RO:0002161 NCBITaxon:28009 property_value: RO:0002161 NCBITaxon:33208 property_value: RO:0002161 NCBITaxon:4751 property_value: RO:0002161 NCBITaxon:554915 [Term] id: GO:0051645 name: Golgi localization namespace: biological_process def: "Any process in which the Golgi is transported to, and/or maintained in, a specific location within the cell." [GOC:ai] synonym: "establishment and maintenance of Golgi localization" EXACT [] synonym: "Golgi apparatus localization" EXACT [] synonym: "Golgi body localization" EXACT [] synonym: "Golgi localisation" EXACT [GOC:mah] is_a: GO:0051640 ! organelle localization intersection_of: GO:0051179 ! localization intersection_of: RO:0004009 GO:0005794 ! has primary input Golgi apparatus relationship: RO:0004009 GO:0005794 ! has primary input Golgi apparatus [Term] id: GO:0051646 name: mitochondrion localization namespace: biological_process def: "Any process in which a mitochondrion or mitochondria are transported to, and/or maintained in, a specific location within the cell." [GOC:ai] synonym: "establishment and maintenance of mitochondria localization" EXACT [] synonym: "establishment and maintenance of mitochondrion localization" EXACT [] synonym: "localization of mitochondria" EXACT [] synonym: "localization of mitochondrion" EXACT [] synonym: "mitochondria localization" EXACT [] synonym: "mitochondrial localization" EXACT [] synonym: "mitochondrion localisation" EXACT [GOC:mah] is_a: GO:0051640 ! organelle localization intersection_of: GO:0051179 ! localization intersection_of: RO:0004009 GO:0005739 ! has primary input mitochondrion relationship: RO:0004009 GO:0005739 ! has primary input mitochondrion [Term] id: GO:0051647 name: nucleus localization namespace: biological_process def: "Any process in which the nucleus is transported to, and/or maintained in, a specific location within the cell." [GOC:ai] synonym: "cell nucleus localization" EXACT [] synonym: "establishment and maintenance of nucleus localization" EXACT [] synonym: "localization of nucleus" EXACT [] synonym: "nucleus localisation" EXACT [GOC:mah] is_a: GO:0051640 ! organelle localization intersection_of: GO:0051179 ! localization intersection_of: RO:0004009 GO:0005634 ! has primary input nucleus relationship: RO:0004009 GO:0005634 ! has primary input nucleus [Term] id: GO:0051648 name: vesicle localization namespace: biological_process def: "Any process in which a vesicle or vesicles are transported to, and/or maintained in, a specific location." [GOC:ai] synonym: "cytoplasmic vesicle localization" EXACT [] synonym: "establishment and maintenance of vesicle localization" EXACT [] synonym: "vesicle localisation" EXACT [GOC:mah] is_a: GO:0051640 ! organelle localization intersection_of: GO:0051179 ! localization intersection_of: RO:0004009 GO:0031982 ! has primary input vesicle relationship: RO:0004009 GO:0031982 ! has primary input vesicle [Term] id: GO:0051649 name: establishment of localization in cell namespace: biological_process def: "Any process, occurring in a cell, that localizes a substance or cellular component. This may occur via movement, tethering or selective degradation." [GOC:ai, GOC:dos, GOC:dph, GOC:tb] synonym: "establishment of cellular localization" RELATED [GOC:dph, GOC:tb] synonym: "establishment of intracellular localization" NARROW [] synonym: "establishment of localisation in cell" EXACT [GOC:mah] synonym: "establishment of localization within cell" NARROW [] synonym: "positioning within cell" NARROW [] is_a: BFO:0000003 is_a: GO:0051234 ! establishment of localization intersection_of: GO:0051234 ! establishment of localization intersection_of: BFO:0000066 CL:0000000 ! occurs in cell relationship: BFO:0000050 GO:0051641 ! part of cellular localization relationship: BFO:0000066 CL:0000000 ! occurs in cell relationship: RO:0002162 NCBITaxon:131567 ! in taxon cellular organisms [Term] id: GO:0051650 name: establishment of vesicle localization namespace: biological_process def: "The directed movement of a vesicle to a specific location." [GOC:ai] synonym: "establishment of vesicle localisation" EXACT [GOC:mah] is_a: GO:0051648 ! vesicle localization is_a: GO:0051649 ! establishment of localization in cell is_a: GO:0051656 ! establishment of organelle localization intersection_of: GO:0051234 ! establishment of localization intersection_of: RO:0004009 GO:0031982 ! has primary input vesicle [Term] id: GO:0051651 name: maintenance of location in cell namespace: biological_process def: "Any process in which a substance or cellular entity, such as a protein complex or organelle, is maintained in a specific location within, or in the membrane of, a cell, and is prevented from moving elsewhere." [GOC:ai] synonym: "cellular retention" NARROW [] synonym: "cellular sequestering" NARROW [] synonym: "cellular storage" NARROW [] synonym: "intracellular retention" NARROW [] synonym: "intracellular sequestering" NARROW [] synonym: "intracellular storage" NARROW [] synonym: "maintenance of cellular localization" RELATED [GOC:dph, GOC:tb] synonym: "maintenance of intracellular localization" NARROW [] synonym: "maintenance of localization in cell" RELATED [GOC:dph, GOC:tb] synonym: "maintenance of localization within cell" NARROW [] synonym: "retention within cell" NARROW [] synonym: "sequestering within cell" NARROW [] synonym: "storage within cell" NARROW [] is_a: BFO:0000003 is_a: GO:0009987 ! cellular process is_a: GO:0051235 ! maintenance of location intersection_of: GO:0051235 ! maintenance of location intersection_of: BFO:0000066 CL:0000000 ! occurs in cell relationship: BFO:0000050 GO:0051641 ! part of cellular localization relationship: BFO:0000066 CL:0000000 ! occurs in cell [Term] id: GO:0051654 name: establishment of mitochondrion localization namespace: biological_process def: "The directed movement of the mitochondrion to a specific location." [GOC:ai] synonym: "establishment of mitochondria localization" EXACT [] synonym: "establishment of mitochondrion localisation" EXACT [GOC:mah] synonym: "mitochondria positioning" EXACT [] synonym: "mitochondrial migration" EXACT [] synonym: "mitochondrion positioning" EXACT [] is_a: GO:0051646 ! mitochondrion localization is_a: GO:0051656 ! establishment of organelle localization intersection_of: GO:0051234 ! establishment of localization intersection_of: RO:0004009 GO:0005739 ! has primary input mitochondrion [Term] id: GO:0051655 name: maintenance of vesicle location namespace: biological_process def: "Any process in which a vesicle is maintained in a specific location within a cell and prevented from moving elsewhere." [GOC:ai, GOC:dph, GOC:tb] synonym: "maintenance of vesicle localization" RELATED [GOC:dph, GOC:tb] is_a: GO:0051648 ! vesicle localization is_a: GO:0051657 ! maintenance of organelle location intersection_of: GO:0051651 ! maintenance of location in cell intersection_of: RO:0004009 GO:0031982 ! has primary input vesicle [Term] id: GO:0051656 name: establishment of organelle localization namespace: biological_process def: "The directed movement of an organelle to a specific location." [GOC:ai] synonym: "establishment of organelle localisation" EXACT [GOC:mah] is_a: GO:0051234 ! establishment of localization is_a: GO:0051640 ! organelle localization intersection_of: GO:0051234 ! establishment of localization intersection_of: RO:0004009 GO:0043226 ! has primary input organelle [Term] id: GO:0051657 name: maintenance of organelle location namespace: biological_process def: "Any process in which an organelle is maintained in a specific location within a cell and prevented from moving elsewhere." [GOC:ai, GOC:dph, GOC:tb] synonym: "maintenance of organelle localization" RELATED [GOC:dph, GOC:tb] is_a: GO:0051651 ! maintenance of location in cell relationship: BFO:0000050 GO:0051640 ! part of organelle localization [Term] id: GO:0051658 name: maintenance of nucleus location namespace: biological_process def: "Any process in which the nucleus is maintained in a specific location within a cell and prevented from moving elsewhere." [GOC:ai, GOC:dph, GOC:tb] synonym: "maintenance of cell nucleus location" EXACT [] synonym: "maintenance of nucleus localization" RELATED [GOC:dph, GOC:tb] is_a: GO:0051647 ! nucleus localization is_a: GO:0051657 ! maintenance of organelle location intersection_of: GO:0051651 ! maintenance of location in cell intersection_of: RO:0004009 GO:0005634 ! has primary input nucleus [Term] id: GO:0051659 name: maintenance of mitochondrion location namespace: biological_process def: "Any process in which a mitochondrion is maintained in a specific location within a cell and prevented from moving elsewhere." [GOC:ai, GOC:dph, GOC:tb] synonym: "maintenance of mitochondria localization" EXACT [] synonym: "maintenance of mitochondrion localization" RELATED [GOC:dph, GOC:tb] is_a: GO:0051646 ! mitochondrion localization is_a: GO:0051657 ! maintenance of organelle location intersection_of: GO:0051651 ! maintenance of location in cell intersection_of: RO:0004009 GO:0005739 ! has primary input mitochondrion [Term] id: GO:0051667 name: establishment of plastid localization namespace: biological_process def: "The directed movement of a plastid to a specific location in the cell." [GOC:ai] synonym: "establishment of plastid localisation" EXACT [GOC:mah] is_a: GO:0051644 ! plastid localization is_a: GO:0051649 ! establishment of localization in cell is_a: GO:0051656 ! establishment of organelle localization intersection_of: GO:0051234 ! establishment of localization intersection_of: RO:0004009 GO:0009536 ! has primary input plastid property_value: RO:0002161 NCBITaxon:28009 property_value: RO:0002161 NCBITaxon:33208 property_value: RO:0002161 NCBITaxon:4751 property_value: RO:0002161 NCBITaxon:554915 [Term] id: GO:0051668 name: localization within membrane namespace: biological_process def: "Any process in which a substance or cellular entity, such as a protein complex or organelle, is transported to, and/or maintained in, a specific location within a membrane." [GOC:ai] synonym: "establishment and maintenance of localization in membrane" EXACT [] synonym: "establishment and maintenance of position in membrane" EXACT [] synonym: "localisation within membrane" EXACT [GOC:mah] synonym: "localization to membrane" EXACT [] synonym: "positioning within membrane" NARROW [] is_a: GO:0051641 ! cellular localization intersection_of: GO:0051179 ! localization intersection_of: RO:0002339 GO:0016020 ! has target end location membrane relationship: RO:0002339 GO:0016020 ! has target end location membrane [Term] id: GO:0051674 name: localization of cell namespace: biological_process def: "Any process in which a cell is transported to, and/or maintained in, a specific location." [GOC:ai] synonym: "cell localization" EXACT [] synonym: "establishment and maintenance of cell localization" EXACT [] synonym: "establishment and maintenance of localization of cell" EXACT [] synonym: "localisation of cell" EXACT [GOC:mah] is_a: BFO:0000003 is_a: GO:0009987 ! cellular process is_a: GO:0051179 ! localization intersection_of: GO:0051179 ! localization intersection_of: RO:0004009 CL:0000000 ! has primary input cell relationship: RO:0004009 CL:0000000 ! has primary input cell [Term] id: GO:0051683 name: establishment of Golgi localization namespace: biological_process def: "The directed movement of the Golgi to a specific location." [GOC:ai] synonym: "establishment of Golgi apparatus localization" EXACT [] synonym: "establishment of Golgi body localization" EXACT [] synonym: "establishment of Golgi localisation" EXACT [GOC:mah] is_a: GO:0051645 ! Golgi localization is_a: GO:0051649 ! establishment of localization in cell is_a: GO:0051656 ! establishment of organelle localization intersection_of: GO:0051234 ! establishment of localization intersection_of: RO:0004009 GO:0005794 ! has primary input Golgi apparatus [Term] id: GO:0051684 name: maintenance of Golgi location namespace: biological_process def: "Any process in which the Golgi is maintained in a specific location within a cell and prevented from moving elsewhere." [GOC:ai, GOC:dph, GOC:tb] synonym: "maintenance of Golgi apparatus localization" EXACT [] synonym: "maintenance of Golgi body localization" EXACT [] synonym: "maintenance of Golgi localization" RELATED [GOC:dph, GOC:tb] is_a: GO:0051645 ! Golgi localization is_a: GO:0051657 ! maintenance of organelle location intersection_of: GO:0051651 ! maintenance of location in cell intersection_of: RO:0004009 GO:0005794 ! has primary input Golgi apparatus [Term] id: GO:0051688 name: maintenance of plastid location namespace: biological_process def: "Any process in which a plastid is maintained in a specific location within a cell and prevented from moving elsewhere." [GOC:ai, GOC:dph, GOC:tb] synonym: "maintenance of plastid localization" RELATED [GOC:dph, GOC:tb] is_a: GO:0051644 ! plastid localization is_a: GO:0051657 ! maintenance of organelle location intersection_of: GO:0051651 ! maintenance of location in cell intersection_of: RO:0004009 GO:0009536 ! has primary input plastid property_value: RO:0002161 NCBITaxon:28009 property_value: RO:0002161 NCBITaxon:33208 property_value: RO:0002161 NCBITaxon:4751 property_value: RO:0002161 NCBITaxon:554915 [Term] id: GO:0051707 name: response to other organism namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from another living organism." [GOC:ai] is_a: GO:0043207 ! response to external biotic stimulus is_a: GO:0044419 ! biological process involved in interspecies interaction between organisms property_value: RO:0002161 NCBITaxon:4895 [Term] id: GO:0051716 name: cellular response to stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. The process begins with detection of the stimulus by a cell and ends with a change in state or activity or the cell." [GOC:bf, GOC:jl] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_annotate xref: Reactome:R-HSA-8953897 "Cellular responses to stimuli" is_a: GO:0009987 ! cellular process is_a: GO:0050896 ! response to stimulus [Term] id: GO:0051726 name: regulation of cell cycle namespace: biological_process def: "Any process that modulates the rate or extent of progression through the cell cycle." [GOC:ai, GOC:dph, GOC:tb] subset: goslim_yeast synonym: "arrest of mitotic cell cycle progression" NARROW [GOC:mah] synonym: "cell cycle arrest" NARROW [] synonym: "cell cycle modulation" EXACT [] synonym: "cell cycle regulation" EXACT [] synonym: "cell cycle regulator" RELATED [] synonym: "control of cell cycle progression" EXACT [] synonym: "mitotic cell cycle arrest" NARROW [] synonym: "modulation of cell cycle progression" EXACT [] synonym: "negative regulation of cell cycle arrest" NARROW [] synonym: "positive regulation of cell cycle arrest" NARROW [] synonym: "regulation of cell cycle arrest" NARROW [] synonym: "regulation of cell cycle progression" EXACT [] synonym: "regulation of progression through cell cycle" EXACT [] synonym: "tumor suppressor" RELATED [] xref: Reactome:R-HSA-156711 "Polo-like kinase mediated events" xref: Reactome:R-HSA-380972 "Energy dependent regulation of mTOR by LKB1-AMPK" is_a: GO:0050794 ! regulation of cellular process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0007049 ! regulates cell cycle relationship: RO:0002211 GO:0007049 ! regulates cell cycle [Term] id: GO:0051738 name: xanthophyll binding namespace: molecular_function def: "Binding to xanthophylls, any of several neutral yellow to orange carotenoid pigments containing oxygen." [ISBN:0122146743] is_a: GO:0019840 ! isoprenoid binding is_a: GO:0031409 ! pigment binding intersection_of: GO:0005488 ! binding intersection_of: RO:0004009 CHEBI:27325 ! has primary input relationship: RO:0004009 CHEBI:27325 ! has primary input [Term] id: GO:0051781 name: positive regulation of cell division namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cell division." [GOC:ai] synonym: "activation of cell division" NARROW [] synonym: "stimulation of cell division" NARROW [] synonym: "up regulation of cell division" EXACT [] synonym: "up-regulation of cell division" EXACT [] synonym: "upregulation of cell division" EXACT [] is_a: GO:0048522 ! positive regulation of cellular process is_a: GO:0051302 ! regulation of cell division intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0051301 ! positively regulates cell division relationship: RO:0002213 GO:0051301 ! positively regulates cell division [Term] id: GO:0051782 name: negative regulation of cell division namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cell division." [GOC:ai] synonym: "down regulation of cell division" EXACT [] synonym: "down-regulation of cell division" EXACT [] synonym: "downregulation of cell division" EXACT [] synonym: "inhibition of cell division" NARROW [] is_a: GO:0048523 ! negative regulation of cellular process is_a: GO:0051302 ! regulation of cell division intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0051301 ! negatively regulates cell division relationship: RO:0002212 GO:0051301 ! negatively regulates cell division [Term] id: GO:0051783 name: regulation of nuclear division namespace: biological_process def: "Any process that modulates the frequency, rate or extent of nuclear division, the partitioning of the nucleus and its genetic information." [GOC:ai] is_a: GO:0033043 ! regulation of organelle organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0000280 ! regulates nuclear division relationship: RO:0002211 GO:0000280 ! regulates nuclear division [Term] id: GO:0051784 name: negative regulation of nuclear division namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of nuclear division, the partitioning of the nucleus and its genetic information." [GOC:ai] synonym: "down regulation of nuclear division" EXACT [] synonym: "down-regulation of nuclear division" EXACT [] synonym: "downregulation of nuclear division" EXACT [] synonym: "inhibition of nuclear division" NARROW [] is_a: GO:0010639 ! negative regulation of organelle organization is_a: GO:0051783 ! regulation of nuclear division intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0000280 ! negatively regulates nuclear division relationship: RO:0002212 GO:0000280 ! negatively regulates nuclear division [Term] id: GO:0051785 name: positive regulation of nuclear division namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of nuclear division, the partitioning of the nucleus and its genetic information." [GOC:ai] synonym: "activation of nuclear division" NARROW [] synonym: "stimulation of nuclear division" NARROW [] synonym: "up regulation of nuclear division" EXACT [] synonym: "up-regulation of nuclear division" EXACT [] synonym: "upregulation of nuclear division" EXACT [] is_a: GO:0010638 ! positive regulation of organelle organization is_a: GO:0051783 ! regulation of nuclear division intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0000280 ! positively regulates nuclear division relationship: RO:0002213 GO:0000280 ! positively regulates nuclear division [Term] id: GO:0051790 name: short-chain fatty acid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a short-chain fatty acid. A short-chain fatty acid has an aliphatic tail containing fewer than 6 carbons." [Wikipedia:Fatty_acid_metabolism] comment: While there is not universal consensus on the lengths of short-, medium-, long- and very-long-chain fatty acids, the GO uses the definitions in ChEBI (see CHEBI:26666, CHEBI:59554, CHEBI:15904 and CHEBI:27283). synonym: "short chain fatty acid biosynthesis" EXACT [] synonym: "short chain fatty acid biosynthetic process" EXACT [] synonym: "short-chain fatty acid anabolism" EXACT [] synonym: "short-chain fatty acid biosynthesis" EXACT [] synonym: "short-chain fatty acid formation" EXACT [] synonym: "short-chain fatty acid synthesis" EXACT [] is_a: GO:0006633 ! fatty acid biosynthetic process is_a: GO:0046459 ! short-chain fatty acid metabolic process intersection_of: GO:0009058 ! biosynthetic process intersection_of: RO:0004008 CHEBI:58951 ! has primary output relationship: RO:0004008 CHEBI:58951 ! has primary output property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/26445" xsd:anyURI [Term] id: GO:0051797 name: regulation of hair follicle development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of hair follicle development." [GOC:ai] is_a: GO:0042634 ! regulation of hair cycle is_a: GO:2000026 ! regulation of multicellular organismal development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0001942 ! regulates hair follicle development relationship: RO:0002211 GO:0001942 ! regulates hair follicle development [Term] id: GO:0051798 name: positive regulation of hair follicle development namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of hair follicle development." [GOC:ai] synonym: "activation of hair follicle development" NARROW [] synonym: "stimulation of hair follicle development" NARROW [] synonym: "up regulation of hair follicle development" EXACT [] synonym: "up-regulation of hair follicle development" EXACT [] synonym: "upregulation of hair follicle development" EXACT [] is_a: GO:0051094 ! positive regulation of developmental process is_a: GO:0051240 ! positive regulation of multicellular organismal process is_a: GO:0051797 ! regulation of hair follicle development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0001942 ! positively regulates hair follicle development relationship: RO:0002213 GO:0001942 ! positively regulates hair follicle development [Term] id: GO:0051799 name: negative regulation of hair follicle development namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of hair follicle development." [GOC:ai] synonym: "down regulation of hair follicle development" EXACT [] synonym: "down-regulation of hair follicle development" EXACT [] synonym: "downregulation of hair follicle development" EXACT [] synonym: "inhibition of hair follicle development" NARROW [] is_a: GO:0051093 ! negative regulation of developmental process is_a: GO:0051241 ! negative regulation of multicellular organismal process is_a: GO:0051797 ! regulation of hair follicle development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0001942 ! negatively regulates hair follicle development relationship: RO:0002212 GO:0001942 ! negatively regulates hair follicle development [Term] id: GO:0051861 name: glycolipid binding namespace: molecular_function def: "Binding to a glycolipid, any compound containing one or more monosaccharide residues bound by a glycosidic linkage to a hydrophobic group such as an acylglycerol, a sphingoid, a ceramide (N-acylsphingoid) or a prenyl phosphate." [PMID:19635802] is_a: GO:0008289 ! lipid binding is_a: GO:0097367 ! carbohydrate derivative binding intersection_of: GO:0005488 ! binding intersection_of: RO:0004009 CHEBI:33563 ! has primary input relationship: RO:0004009 CHEBI:33563 ! has primary input [Term] id: GO:0051875 name: pigment granule localization namespace: biological_process def: "Any process in which a pigment granule is transported to, and/or maintained in, a specific location within the cell." [GOC:ai] synonym: "pigment granule localisation" EXACT [GOC:mah] is_a: GO:0051648 ! vesicle localization intersection_of: GO:0051179 ! localization intersection_of: RO:0004009 GO:0048770 ! has primary input pigment granule relationship: BFO:0000050 GO:0033059 ! part of cellular pigmentation relationship: RO:0004009 GO:0048770 ! has primary input pigment granule [Term] id: GO:0051881 name: regulation of mitochondrial membrane potential namespace: biological_process def: "Any process that modulates the establishment or extent of the mitochondrial membrane potential, the electric potential existing across the mitochondrial membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane." [GOC:ai] is_a: GO:0042391 ! regulation of membrane potential [Term] id: GO:0051882 name: mitochondrial depolarization namespace: biological_process def: "The process in which the potential difference across the mitochondrial membrane is reduced from its steady state level." [Wikipedia:Depolarization, Wikipedia:Mitochondrion] synonym: "mitochondria depolarization" EXACT [] synonym: "mitochondrial depolarisation" EXACT [] synonym: "mitochondrial membrane depolarization" EXACT [] synonym: "mitochondrion depolarization" EXACT [] is_a: GO:0051881 ! regulation of mitochondrial membrane potential is_a: GO:0051899 ! membrane depolarization intersection_of: GO:0051899 ! membrane depolarization intersection_of: BFO:0000066 GO:0005739 ! occurs in mitochondrion relationship: BFO:0000066 GO:0005739 ! occurs in mitochondrion relationship: RO:0002162 NCBITaxon:2759 ! in taxon Eukaryota [Term] id: GO:0051890 name: regulation of cardioblast differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cardioblast differentiation, the process in which a relatively unspecialized mesodermal cell acquires the specialized structural and/or functional features of a cardioblast. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating." [GOC:ai] is_a: GO:1905207 ! regulation of cardiocyte differentiation is_a: GO:2000736 ! regulation of stem cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0010002 ! regulates cardioblast differentiation relationship: RO:0002211 GO:0010002 ! regulates cardioblast differentiation [Term] id: GO:0051891 name: positive regulation of cardioblast differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cardioblast differentiation, the process in which a relatively unspecialized mesodermal cell acquires the specialized structural and/or functional features of a cardioblast. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating." [GOC:ai] synonym: "activation of cardioblast differentiation" NARROW [] synonym: "stimulation of cardioblast differentiation" NARROW [] synonym: "up regulation of cardioblast differentiation" EXACT [] synonym: "up-regulation of cardioblast differentiation" EXACT [] synonym: "upregulation of cardioblast differentiation" EXACT [] is_a: GO:0051890 ! regulation of cardioblast differentiation is_a: GO:1905209 ! positive regulation of cardiocyte differentiation is_a: GO:2000738 ! positive regulation of stem cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0010002 ! positively regulates cardioblast differentiation relationship: RO:0002213 GO:0010002 ! positively regulates cardioblast differentiation [Term] id: GO:0051892 name: negative regulation of cardioblast differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cardioblast differentiation, the process in which a relatively unspecialized mesodermal cell acquires the specialized structural and/or functional features of a cardioblast. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating." [GOC:ai] synonym: "down regulation of cardioblast differentiation" EXACT [] synonym: "down-regulation of cardioblast differentiation" EXACT [] synonym: "downregulation of cardioblast differentiation" EXACT [] synonym: "inhibition of cardioblast differentiation" NARROW [] is_a: GO:0051890 ! regulation of cardioblast differentiation is_a: GO:1905208 ! negative regulation of cardiocyte differentiation is_a: GO:2000737 ! negative regulation of stem cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0010002 ! negatively regulates cardioblast differentiation relationship: RO:0002212 GO:0010002 ! negatively regulates cardioblast differentiation [Term] id: GO:0051899 name: membrane depolarization namespace: biological_process def: "The process in which membrane potential decreases with respect to its steady-state potential, usually from negative potential to a more positive potential. For example, the initial depolarization during the rising phase of an action potential is in the direction from the negative steady-state resting potential towards the positive membrane potential that will be the peak of the action potential." [GOC:dh, Wikipedia:Depolarization] xref: Reactome:R-HSA-112308 "Presynaptic depolarization and calcium channel opening" is_a: GO:0042391 ! regulation of membrane potential [Term] id: GO:0051900 name: regulation of mitochondrial depolarization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the change in the membrane potential of the mitochondria from negative to positive." [GOC:ai] is_a: GO:0003254 ! regulation of membrane depolarization is_a: GO:0051881 ! regulation of mitochondrial membrane potential intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0051882 ! regulates mitochondrial depolarization relationship: RO:0002211 GO:0051882 ! regulates mitochondrial depolarization [Term] id: GO:0051901 name: positive regulation of mitochondrial depolarization namespace: biological_process def: "Any process that activates, maintains or increases the frequency, rate or extent of the change in the membrane potential of the mitochondria from negative to positive." [GOC:ai] synonym: "activation of mitochondrial depolarization" NARROW [] synonym: "stimulation of mitochondrial depolarization" NARROW [] synonym: "up regulation of mitochondrial depolarization" EXACT [] synonym: "up-regulation of mitochondrial depolarization" EXACT [] synonym: "upregulation of mitochondrial depolarization" EXACT [] is_a: GO:0051900 ! regulation of mitochondrial depolarization is_a: GO:1904181 ! positive regulation of membrane depolarization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0051882 ! positively regulates mitochondrial depolarization relationship: RO:0002213 GO:0051882 ! positively regulates mitochondrial depolarization [Term] id: GO:0051902 name: negative regulation of mitochondrial depolarization namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the change in the membrane potential of the mitochondria from negative to positive." [GOC:ai] synonym: "down regulation of mitochondrial depolarization" EXACT [] synonym: "down-regulation of mitochondrial depolarization" EXACT [] synonym: "downregulation of mitochondrial depolarization" EXACT [] synonym: "inhibition of mitochondrial depolarization" NARROW [] is_a: GO:0051900 ! regulation of mitochondrial depolarization is_a: GO:1904180 ! negative regulation of membrane depolarization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0051882 ! negatively regulates mitochondrial depolarization relationship: RO:0002212 GO:0051882 ! negatively regulates mitochondrial depolarization [Term] id: GO:0051904 name: pigment granule transport namespace: biological_process def: "The directed movement of pigment granules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] synonym: "pigment granule translocation" EXACT [] is_a: GO:0006810 ! transport is_a: GO:0051875 ! pigment granule localization is_a: GO:0051905 ! establishment of pigment granule localization intersection_of: GO:0006810 ! transport intersection_of: RO:0004009 GO:0048770 ! has primary input pigment granule [Term] id: GO:0051905 name: establishment of pigment granule localization namespace: biological_process def: "The directed movement of a pigment granule to a specific location." [GOC:ai] synonym: "establishment of pigment granule localisation" EXACT [GOC:mah] is_a: GO:0051650 ! establishment of vesicle localization relationship: BFO:0000050 GO:0051875 ! part of pigment granule localization [Term] id: GO:0051924 name: regulation of calcium ion transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the directed movement of calcium ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] synonym: "regulation of calcium transport" EXACT [] is_a: GO:0010959 ! regulation of metal ion transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0006816 ! regulates calcium ion transport relationship: RO:0002211 GO:0006816 ! regulates calcium ion transport [Term] id: GO:0051926 name: negative regulation of calcium ion transport namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of calcium ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] synonym: "down regulation of calcium ion transport" EXACT [] synonym: "down-regulation of calcium ion transport" EXACT [] synonym: "downregulation of calcium ion transport" EXACT [] synonym: "inhibition of calcium ion transport" NARROW [] synonym: "negative regulation of calcium transport" EXACT [] is_a: GO:0043271 ! negative regulation of monoatomic ion transport is_a: GO:0051924 ! regulation of calcium ion transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0006816 ! negatively regulates calcium ion transport relationship: RO:0002212 GO:0006816 ! negatively regulates calcium ion transport [Term] id: GO:0051928 name: positive regulation of calcium ion transport namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the directed movement of calcium ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] synonym: "activation of calcium ion transport" NARROW [] synonym: "positive regulation of calcium transport" EXACT [] synonym: "stimulation of calcium ion transport" NARROW [] synonym: "up regulation of calcium ion transport" EXACT [] synonym: "up-regulation of calcium ion transport" EXACT [] synonym: "upregulation of calcium ion transport" EXACT [] is_a: GO:0043270 ! positive regulation of monoatomic ion transport is_a: GO:0051924 ! regulation of calcium ion transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0006816 ! positively regulates calcium ion transport relationship: RO:0002213 GO:0006816 ! positively regulates calcium ion transport [Term] id: GO:0051930 name: regulation of sensory perception of pain namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the sensory perception of pain, the series of events required for an organism to receive a painful stimulus, convert it to a molecular signal, and recognize and characterize the signal." [GOC:ai] is_a: GO:0051931 ! regulation of sensory perception intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0019233 ! regulates sensory perception of pain relationship: RO:0002211 GO:0019233 ! regulates sensory perception of pain [Term] id: GO:0051931 name: regulation of sensory perception namespace: biological_process def: "Any process that modulates the frequency, rate or extent of sensory perception, the series of events required for an organism to receive a sensory stimulus, convert it to a molecular signal, and recognize and characterize the signal." [GOC:ai] is_a: GO:0031644 ! regulation of nervous system process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0007600 ! regulates sensory perception relationship: RO:0002211 GO:0007600 ! regulates sensory perception [Term] id: GO:0051932 name: synaptic transmission, GABAergic namespace: biological_process def: "The vesicular release of gamma-aminobutyric acid (GABA). from a presynapse, across a chemical synapse, the subsequent activation of GABA receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse." [GOC:dos, ISBN:0126603030] synonym: "GABAergic synaptic transmission" EXACT [] synonym: "synaptic transmission, GABA mediated" EXACT [] synonym: "synaptic transmission, gamma-aminobutyric acid mediated" EXACT [] synonym: "synaptic transmission, gamma-aminobutyric acid-ergic" EXACT [] is_a: GO:0007268 ! chemical synaptic transmission intersection_of: GO:0007268 ! chemical synaptic transmission intersection_of: has_participant CHEBI:59888 intersection_of: has_participant CL:0000617 ! GABAergic neuron relationship: has_participant CHEBI:59888 relationship: has_participant CL:0000617 ! GABAergic neuron [Term] id: GO:0051937 name: catecholamine transport namespace: biological_process def: "The directed movement of catecholamines, a group of physiologically important biogenic amines that possess a catechol (3,4-dihydroxyphenyl) nucleus and are derivatives of 3,4-dihydroxyphenylethylamine." [GOC:ai, ISBN:0198506732] is_a: GO:0015844 ! monoamine transport is_a: GO:0015850 ! organic hydroxy compound transport intersection_of: GO:0006810 ! transport intersection_of: RO:0004009 CHEBI:33567 ! has primary input relationship: RO:0004009 CHEBI:33567 ! has primary input [Term] id: GO:0051938 name: L-glutamate import namespace: biological_process def: "The directed movement of L-glutamate, the L-enantiomer of the anion of 2-aminopentanedioic acid, into a cell or organelle." [GOC:ai, GOC:jsg, GOC:mah] synonym: "L-glutamate uptake" EXACT [GOC:dph, GOC:tb] is_a: GO:0006835 ! dicarboxylic acid transport is_a: GO:0015800 ! acidic amino acid transport is_a: GO:0015807 ! L-amino acid transport intersection_of: GO:0006810 ! transport intersection_of: RO:0004009 CHEBI:29985 ! has primary input relationship: RO:0004009 CHEBI:29985 ! has primary input [Term] id: GO:0051939 name: gamma-aminobutyric acid import namespace: biological_process def: "The directed movement of gamma-aminobutyric acid (GABA, 4-aminobutyrate) into a cell or organelle." [GOC:ai] synonym: "4-aminobutyrate import" EXACT [] synonym: "GABA import" EXACT [] synonym: "gamma-aminobutyrate import" EXACT [] synonym: "gamma-aminobutyric acid uptake" EXACT [GOC:dph, GOC:tb] is_a: GO:0015800 ! acidic amino acid transport is_a: GO:0015812 ! gamma-aminobutyric acid transport intersection_of: GO:0015800 ! acidic amino acid transport intersection_of: RO:0004009 CHEBI:59888 ! has primary input [Term] id: GO:0051952 name: regulation of amine transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the directed movement of amines into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] is_a: GO:0051049 ! regulation of transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0015837 ! regulates amine transport relationship: RO:0002211 GO:0015837 ! regulates amine transport [Term] id: GO:0051953 name: negative regulation of amine transport namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of amines into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] synonym: "down regulation of amine transport" EXACT [] synonym: "down-regulation of amine transport" EXACT [] synonym: "downregulation of amine transport" EXACT [] synonym: "inhibition of amine transport" NARROW [] is_a: GO:0051051 ! negative regulation of transport is_a: GO:0051952 ! regulation of amine transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0015837 ! negatively regulates amine transport relationship: RO:0002212 GO:0015837 ! negatively regulates amine transport [Term] id: GO:0051954 name: positive regulation of amine transport namespace: biological_process def: "Any process that activates, maintains or increases the frequency, rate or extent of the directed movement of amines into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] synonym: "activation of amine transport" NARROW [] synonym: "stimulation of amine transport" NARROW [] synonym: "up regulation of amine transport" EXACT [] synonym: "up-regulation of amine transport" EXACT [] synonym: "upregulation of amine transport" EXACT [] is_a: GO:0051050 ! positive regulation of transport is_a: GO:0051952 ! regulation of amine transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0015837 ! positively regulates amine transport relationship: RO:0002213 GO:0015837 ! positively regulates amine transport [Term] id: GO:0051955 name: regulation of amino acid transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the directed movement of amino acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] is_a: GO:0051952 ! regulation of amine transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0006865 ! regulates amino acid transport relationship: RO:0002211 GO:0006865 ! regulates amino acid transport [Term] id: GO:0051956 name: negative regulation of amino acid transport namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of amino acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] synonym: "down regulation of amino acid transport" EXACT [] synonym: "down-regulation of amino acid transport" EXACT [] synonym: "downregulation of amino acid transport" EXACT [] synonym: "inhibition of amino acid transport" NARROW [] synonym: "negative regulation of amino acid transmembrane transport" EXACT [GOC:mah] is_a: GO:0051953 ! negative regulation of amine transport is_a: GO:0051955 ! regulation of amino acid transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0006865 ! negatively regulates amino acid transport relationship: RO:0002212 GO:0006865 ! negatively regulates amino acid transport [Term] id: GO:0051957 name: positive regulation of amino acid transport namespace: biological_process def: "Any process that activates, maintains or increases the frequency, rate or extent of the directed movement of amino acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] synonym: "activation of amino acid transport" NARROW [] synonym: "positive regulation of amino acid transmembrane transport" EXACT [GOC:mah] synonym: "stimulation of amino acid transport" NARROW [] synonym: "up regulation of amino acid transport" EXACT [] synonym: "up-regulation of amino acid transport" EXACT [] synonym: "upregulation of amino acid transport" EXACT [] is_a: GO:0051954 ! positive regulation of amine transport is_a: GO:0051955 ! regulation of amino acid transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0006865 ! positively regulates amino acid transport relationship: RO:0002213 GO:0006865 ! positively regulates amino acid transport [Term] id: GO:0051960 name: regulation of nervous system development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of nervous system development, the origin and formation of nervous tissue." [GOC:ai] is_a: GO:2000026 ! regulation of multicellular organismal development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0007399 ! regulates nervous system development relationship: RO:0002211 GO:0007399 ! regulates nervous system development [Term] id: GO:0051961 name: negative regulation of nervous system development namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of nervous system development, the origin and formation of nervous tissue." [GOC:ai] synonym: "down regulation of nervous system development" EXACT [] synonym: "down-regulation of nervous system development" EXACT [] synonym: "downregulation of nervous system development" EXACT [] synonym: "inhibition of nervous system development" NARROW [] is_a: GO:0051093 ! negative regulation of developmental process is_a: GO:0051241 ! negative regulation of multicellular organismal process is_a: GO:0051960 ! regulation of nervous system development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0007399 ! negatively regulates nervous system development relationship: RO:0002212 GO:0007399 ! negatively regulates nervous system development [Term] id: GO:0051962 name: positive regulation of nervous system development namespace: biological_process def: "Any process that activates, maintains or increases the frequency, rate or extent of nervous system development, the origin and formation of nervous tissue." [GOC:ai] synonym: "activation of nervous system development" NARROW [] synonym: "stimulation of nervous system development" NARROW [] synonym: "up regulation of nervous system development" EXACT [] synonym: "up-regulation of nervous system development" EXACT [] synonym: "upregulation of nervous system development" EXACT [] is_a: GO:0051094 ! positive regulation of developmental process is_a: GO:0051240 ! positive regulation of multicellular organismal process is_a: GO:0051960 ! regulation of nervous system development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0007399 ! positively regulates nervous system development relationship: RO:0002213 GO:0007399 ! positively regulates nervous system development [Term] id: GO:0051963 name: regulation of synapse assembly namespace: biological_process def: "Any process that modulates the frequency, rate or extent of synapse assembly, the aggregation, arrangement and bonding together of a set of components to form a synapse." [GOC:ai, GOC:pr] subset: goslim_synapse synonym: "regulation of synapse biogenesis" EXACT [] synonym: "regulation of synaptogenesis" EXACT [] is_a: GO:0050807 ! regulation of synapse organization is_a: GO:1901888 ! regulation of cell junction assembly intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0007416 ! regulates synapse assembly relationship: RO:0002211 GO:0007416 ! regulates synapse assembly [Term] id: GO:0051964 name: negative regulation of synapse assembly namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of synapse assembly, the aggregation, arrangement and bonding together of a set of components to form a synapse." [GOC:ai, GOC:pr] synonym: "down regulation of synapse assembly" EXACT [] synonym: "down-regulation of synapse assembly" EXACT [] synonym: "downregulation of synapse assembly" EXACT [] synonym: "inhibition of synapse assembly" NARROW [] synonym: "negative regulation of synapse biogenesis" EXACT [] synonym: "negative regulation of synaptogenesis" EXACT [] is_a: GO:0051961 ! negative regulation of nervous system development is_a: GO:0051963 ! regulation of synapse assembly is_a: GO:1901889 ! negative regulation of cell junction assembly is_a: GO:1905809 ! negative regulation of synapse organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0007416 ! negatively regulates synapse assembly relationship: RO:0002212 GO:0007416 ! negatively regulates synapse assembly [Term] id: GO:0051965 name: positive regulation of synapse assembly namespace: biological_process def: "Any process that activates, maintains or increases the frequency, rate or extent of synapse assembly, the aggregation, arrangement and bonding together of a set of components to form a synapse." [GOC:ai, GOC:pr] synonym: "activation of synapse assembly" NARROW [] synonym: "positive regulation of synapse biogenesis" EXACT [] synonym: "positive regulation of synaptogenesis" EXACT [] synonym: "stimulation of synapse assembly" NARROW [] synonym: "up regulation of synapse assembly" EXACT [] synonym: "up-regulation of synapse assembly" EXACT [] synonym: "upregulation of synapse assembly" EXACT [] is_a: GO:0051962 ! positive regulation of nervous system development is_a: GO:0051963 ! regulation of synapse assembly is_a: GO:1901890 ! positive regulation of cell junction assembly intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0007416 ! positively regulates synapse assembly relationship: RO:0002213 GO:0007416 ! positively regulates synapse assembly [Term] id: GO:0051966 name: regulation of synaptic transmission, glutamatergic namespace: biological_process def: "Any process that modulates the frequency, rate or extent of glutamatergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter glutamate." [GOC:ai] is_a: GO:0050804 ! modulation of chemical synaptic transmission intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0035249 ! regulates synaptic transmission, glutamatergic relationship: RO:0002211 GO:0035249 ! regulates synaptic transmission, glutamatergic [Term] id: GO:0051967 name: negative regulation of synaptic transmission, glutamatergic namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of glutamatergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter glutamate." [GOC:ai] synonym: "down regulation of synaptic transmission, glutamatergic" EXACT [] synonym: "down-regulation of synaptic transmission, glutamatergic" EXACT [] synonym: "downregulation of synaptic transmission, glutamatergic" EXACT [] synonym: "inhibition of synaptic transmission, glutamatergic" NARROW [] is_a: GO:0050805 ! negative regulation of synaptic transmission is_a: GO:0051966 ! regulation of synaptic transmission, glutamatergic intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0035249 ! negatively regulates synaptic transmission, glutamatergic relationship: RO:0002212 GO:0035249 ! negatively regulates synaptic transmission, glutamatergic [Term] id: GO:0051968 name: positive regulation of synaptic transmission, glutamatergic namespace: biological_process def: "Any process that activates, maintains or increases the frequency, rate or extent of glutamatergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter glutamate." [GOC:ai] synonym: "activation of synaptic transmission, glutamatergic" NARROW [] synonym: "stimulation of synaptic transmission, glutamatergic" NARROW [] synonym: "up regulation of synaptic transmission, glutamatergic" EXACT [] synonym: "up-regulation of synaptic transmission, glutamatergic" EXACT [] synonym: "upregulation of synaptic transmission, glutamatergic" EXACT [] is_a: GO:0050806 ! positive regulation of synaptic transmission is_a: GO:0051966 ! regulation of synaptic transmission, glutamatergic intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0035249 ! positively regulates synaptic transmission, glutamatergic relationship: RO:0002213 GO:0035249 ! positively regulates synaptic transmission, glutamatergic [Term] id: GO:0051969 name: regulation of transmission of nerve impulse namespace: biological_process def: "Any process that modulates the frequency, rate or extent of transmission of a nerve impulse, the sequential electrochemical polarization and depolarization that travels across the membrane of a neuron in response to stimulation." [GOC:ai] synonym: "regulation of conduction of nerve impulse" EXACT [GOC:dph] is_a: GO:0010646 ! regulation of cell communication is_a: GO:0031644 ! regulation of nervous system process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0019226 ! regulates transmission of nerve impulse relationship: RO:0002211 GO:0019226 ! regulates transmission of nerve impulse [Term] id: GO:0051970 name: negative regulation of transmission of nerve impulse namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of transmission of a nerve impulse, the sequential electrochemical polarization and depolarization that travels across the membrane of a neuron in response to stimulation." [GOC:ai] synonym: "down regulation of transmission of nerve impulse" EXACT [] synonym: "down-regulation of transmission of nerve impulse" EXACT [] synonym: "downregulation of transmission of nerve impulse" EXACT [] synonym: "inhibition of transmission of nerve impulse" NARROW [] synonym: "negative regulation of conduction of nerve impulse" EXACT [GOC:dph] is_a: GO:0010648 ! negative regulation of cell communication is_a: GO:0031645 ! negative regulation of nervous system process is_a: GO:0051969 ! regulation of transmission of nerve impulse intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0019226 ! negatively regulates transmission of nerve impulse relationship: RO:0002212 GO:0019226 ! negatively regulates transmission of nerve impulse [Term] id: GO:0051971 name: positive regulation of transmission of nerve impulse namespace: biological_process def: "Any process that activates, maintains or increases the frequency, rate or extent of transmission of a nerve impulse, the sequential electrochemical polarization and depolarization that travels across the membrane of a neuron in response to stimulation." [GOC:ai] synonym: "activation of transmission of nerve impulse" NARROW [] synonym: "positive regulation of conduction of nerve impulse" EXACT [GOC:dph] synonym: "stimulation of transmission of nerve impulse" NARROW [] synonym: "up regulation of transmission of nerve impulse" EXACT [] synonym: "up-regulation of transmission of nerve impulse" EXACT [] synonym: "upregulation of transmission of nerve impulse" EXACT [] is_a: GO:0010647 ! positive regulation of cell communication is_a: GO:0031646 ! positive regulation of nervous system process is_a: GO:0051969 ! regulation of transmission of nerve impulse intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0019226 ! positively regulates transmission of nerve impulse relationship: RO:0002213 GO:0019226 ! positively regulates transmission of nerve impulse [Term] id: GO:0051983 name: regulation of chromosome segregation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of chromosome segregation, the process in which genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets." [GOC:ai] is_a: GO:0010564 ! regulation of cell cycle process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0007059 ! regulates chromosome segregation relationship: RO:0002211 GO:0007059 ! regulates chromosome segregation [Term] id: GO:0051984 name: positive regulation of chromosome segregation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of chromosome segregation, the process in which genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets." [GOC:ai] synonym: "activation of chromosome segregation" NARROW [] synonym: "stimulation of chromosome segregation" NARROW [] synonym: "up regulation of chromosome segregation" EXACT [] synonym: "up-regulation of chromosome segregation" EXACT [] synonym: "upregulation of chromosome segregation" EXACT [] is_a: GO:0051983 ! regulation of chromosome segregation is_a: GO:0090068 ! positive regulation of cell cycle process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0007059 ! positively regulates chromosome segregation relationship: RO:0002213 GO:0007059 ! positively regulates chromosome segregation [Term] id: GO:0051985 name: negative regulation of chromosome segregation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of chromosome segregation, the process in which genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets." [GOC:ai] synonym: "down regulation of chromosome segregation" EXACT [] synonym: "down-regulation of chromosome segregation" EXACT [] synonym: "downregulation of chromosome segregation" EXACT [] synonym: "inhibition of chromosome segregation" NARROW [] is_a: GO:0010948 ! negative regulation of cell cycle process is_a: GO:0051983 ! regulation of chromosome segregation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0007059 ! negatively regulates chromosome segregation relationship: RO:0002212 GO:0007059 ! negatively regulates chromosome segregation [Term] id: GO:0052803 name: imidazole-containing compound metabolic process namespace: biological_process def: "The chemical reactions and pathways involving imidazoles, five-membered organic heterocycle containing two nitrogen atoms at positions 1 and 3, or any of its derivatives; compounds containing an imidazole skeleton." [GOC:curators] synonym: "imidazole metabolism" EXACT [] is_a: BFO:0000003 is_a: GO:0008152 ! metabolic process intersection_of: GO:0008152 ! metabolic process intersection_of: RO:0004007 CHEBI:24780 ! has primary input or output relationship: RO:0004007 CHEBI:24780 ! has primary input or output [Term] id: GO:0052805 name: imidazole-containing compound catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of imidazoles, five-membered organic heterocycle containing two nitrogen atoms at positions 1 and 3, or any of its derivatives; compounds containing an imidazole skeleton." [GOC:curators] synonym: "imidazole breakdown" EXACT [] synonym: "imidazole catabolism" EXACT [] synonym: "imidazole degradation" EXACT [] is_a: GO:0009056 ! catabolic process is_a: GO:0052803 ! imidazole-containing compound metabolic process intersection_of: GO:0009056 ! catabolic process intersection_of: RO:0004009 CHEBI:24780 ! has primary input relationship: RO:0004009 CHEBI:24780 ! has primary input [Term] id: GO:0055001 name: muscle cell development namespace: biological_process def: "The process whose specific outcome is the progression of a muscle cell over time, from its formation to the mature structure. Muscle cell development does not include the steps involved in committing an unspecified cell to the muscle cell fate." [CL:0000187, GOC:devbiol] synonym: "muscle fiber development" EXACT [] synonym: "muscle fibre development" EXACT [] synonym: "myofiber development" EXACT [] synonym: "myofibre development" EXACT [] is_a: GO:0048468 ! cell development intersection_of: GO:0032502 ! developmental process intersection_of: RO:0002296 CL:0000187 ! results in development of muscle cell relationship: BFO:0000050 GO:0042692 ! part of muscle cell differentiation relationship: RO:0002296 CL:0000187 ! results in development of muscle cell [Term] id: GO:0055002 name: striated muscle cell development namespace: biological_process def: "The process whose specific outcome is the progression of a striated muscle cell over time, from its formation to the mature structure. Striated muscle cells contain fibers that are divided by transverse bands into striations, and cardiac and skeletal muscle are types of striated muscle." [CL:0000737, GOC:devbiol] is_a: GO:0055001 ! muscle cell development intersection_of: GO:0032502 ! developmental process intersection_of: RO:0002296 CL:0000737 ! results in development of striated muscle cell relationship: BFO:0000050 GO:0051146 ! part of striated muscle cell differentiation relationship: RO:0002296 CL:0000737 ! results in development of striated muscle cell [Term] id: GO:0055003 name: cardiac myofibril assembly namespace: biological_process def: "The process whose specific outcome is the progression of the cardiac myofibril over time, from its formation to the mature structure. A cardiac myofibril is a myofibril specific to cardiac muscle cells." [GOC:devbiol] synonym: "cardiac myofibril development" EXACT [] synonym: "cardiac myofibril morphogenesis" EXACT [] synonym: "heart myofibril assembly" RELATED [] is_a: GO:0030239 ! myofibril assembly intersection_of: GO:0022607 ! cellular component assembly intersection_of: RO:0002588 GO:0097512 ! results in assembly of cardiac myofibril relationship: BFO:0000050 GO:0055013 ! part of cardiac muscle cell development relationship: RO:0002588 GO:0097512 ! results in assembly of cardiac myofibril [Term] id: GO:0055006 name: cardiac cell development namespace: biological_process def: "The process whose specific outcome is the progression of a cardiac cell over time, from its formation to the mature state. A cardiac cell is a cell that will form part of the cardiac organ of an individual." [GOC:devbiol] synonym: "cardiocyte development" EXACT [GOC:dph] synonym: "heart cell development" RELATED [] is_a: GO:0048468 ! cell development intersection_of: GO:0032502 ! developmental process intersection_of: RO:0002296 CL:0002494 ! results in development of cardiocyte relationship: BFO:0000050 GO:0035051 ! part of cardiocyte differentiation relationship: RO:0002296 CL:0002494 ! results in development of cardiocyte [Term] id: GO:0055007 name: cardiac muscle cell differentiation namespace: biological_process def: "The process in which a cardiac muscle precursor cell acquires specialized features of a cardiac muscle cell. Cardiac muscle cells are striated muscle cells that are responsible for heart contraction." [GOC:devbiol, GOC:mtg_heart] synonym: "cardiomyocyte differentiation" EXACT [] synonym: "heart muscle cell differentiation" RELATED [] is_a: GO:0035051 ! cardiocyte differentiation is_a: GO:0051146 ! striated muscle cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000746 ! results in acquisition of features of cardiac muscle cell relationship: BFO:0000050 GO:0048738 ! part of cardiac muscle tissue development relationship: RO:0002315 CL:0000746 ! results in acquisition of features of cardiac muscle cell [Term] id: GO:0055008 name: cardiac muscle tissue morphogenesis namespace: biological_process def: "The process in which the anatomical structures of cardiac muscle tissue are generated and organized." [GOC:devbiol] synonym: "heart muscle morphogenesis" EXACT [] synonym: "myocardium morphogenesis" BROAD [GOC:mtg_heart] is_a: GO:0060415 ! muscle tissue morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0001133 ! results in morphogenesis of cardiac muscle tissue relationship: BFO:0000050 GO:0003007 ! part of heart morphogenesis relationship: BFO:0000050 GO:0048738 ! part of cardiac muscle tissue development relationship: RO:0002298 UBERON:0001133 ! results in morphogenesis of cardiac muscle tissue [Term] id: GO:0055009 name: atrial cardiac muscle tissue morphogenesis namespace: biological_process def: "The process in which the anatomical structure of cardiac atrium muscle is generated and organized." [GOC:devbiol] synonym: "atrial heart muscle morphogenesis" EXACT [] synonym: "atrial myocardium morphogenesis" EXACT [GOC:mtg_heart] synonym: "cardiac atrium muscle morphogenesis" EXACT [] is_a: GO:0055008 ! cardiac muscle tissue morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0004490 ! results in morphogenesis of cardiac muscle tissue of atrium relationship: BFO:0000050 GO:0003209 ! part of cardiac atrium morphogenesis relationship: BFO:0000050 GO:0003228 ! part of atrial cardiac muscle tissue development relationship: RO:0002298 UBERON:0004490 ! results in morphogenesis of cardiac muscle tissue of atrium [Term] id: GO:0055010 name: ventricular cardiac muscle tissue morphogenesis namespace: biological_process def: "The process in which the anatomical structures of cardiac ventricle muscle is generated and organized." [GOC:devbiol] synonym: "cardiac ventricle muscle morphogenesis" EXACT [] synonym: "ventricular heart muscle morphogenesis" EXACT [] is_a: GO:0055008 ! cardiac muscle tissue morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0018649 ! results in morphogenesis of cardiac muscle tissue of ventricle relationship: BFO:0000050 GO:0003208 ! part of cardiac ventricle morphogenesis relationship: BFO:0000050 GO:0003229 ! part of ventricular cardiac muscle tissue development relationship: RO:0002298 UBERON:0018649 ! results in morphogenesis of cardiac muscle tissue of ventricle [Term] id: GO:0055011 name: atrial cardiac muscle cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a cardiac muscle cell in the atrium. Cardiac muscle cells are striated muscle cells that are responsible for heart contraction. The atrium is the part of the heart that receives blood into the organ." [GOC:devbiol, GOC:mtg_heart] synonym: "atrial cardiomyocyte differentiation" EXACT [] synonym: "atrial heart muscle cell differentiation" EXACT [] is_a: GO:0055007 ! cardiac muscle cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0002129 ! results in acquisition of features of regular atrial cardiac myocyte relationship: RO:0002315 CL:0002129 ! results in acquisition of features of regular atrial cardiac myocyte [Term] id: GO:0055013 name: cardiac muscle cell development namespace: biological_process def: "The process whose specific outcome is the progression of a cardiac muscle cell over time, from its formation to the mature state." [GOC:devbiol, GOC:mtg_heart] synonym: "cardiac muscle fiber development" EXACT [] synonym: "cardiac muscle fibre development" EXACT [] synonym: "cardiomyocyte cell development" EXACT [GOC:mtg_muscle] synonym: "heart muscle cell development" EXACT [] synonym: "heart muscle fiber development" RELATED [] is_a: GO:0055002 ! striated muscle cell development is_a: GO:0055006 ! cardiac cell development intersection_of: GO:0032502 ! developmental process intersection_of: RO:0002296 CL:0000746 ! results in development of cardiac muscle cell relationship: BFO:0000050 GO:0055007 ! part of cardiac muscle cell differentiation relationship: RO:0002296 CL:0000746 ! results in development of cardiac muscle cell [Term] id: GO:0055014 name: atrial cardiac muscle cell development namespace: biological_process def: "The process whose specific outcome is the progression of an atrial cardiac muscle cell over time, from its formation to the mature state. Cardiac muscle cells are striated muscle cells that are responsible for heart contraction. The atrium is the part of the heart that receives blood into the organ." [GOC:devbiol] synonym: "atrial cardiomyocyte development" EXACT [] synonym: "atrial heart muscle development" EXACT [] is_a: GO:0055013 ! cardiac muscle cell development intersection_of: GO:0048468 ! cell development intersection_of: RO:0002296 CL:0002129 ! results in development of regular atrial cardiac myocyte relationship: BFO:0000050 GO:0055011 ! part of atrial cardiac muscle cell differentiation relationship: RO:0002296 CL:0002129 ! results in development of regular atrial cardiac myocyte [Term] id: GO:0055017 name: cardiac muscle tissue growth namespace: biological_process def: "The increase in size or mass of a cardiac muscle, where the increase in size or mass has the specific outcome of the progression of the organism over time from one condition to another." [GOC:devbiol] synonym: "heart muscle growth" EXACT [] is_a: BFO:0000003 is_a: GO:0048589 ! developmental growth intersection_of: GO:0048589 ! developmental growth intersection_of: RO:0002343 UBERON:0001133 ! results in growth of cardiac muscle tissue relationship: BFO:0000050 GO:0048738 ! part of cardiac muscle tissue development relationship: BFO:0000050 GO:0060419 ! part of heart growth relationship: RO:0002343 UBERON:0001133 ! results in growth of cardiac muscle tissue [Term] id: GO:0055018 name: regulation of cardiac muscle fiber development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cardiac muscle fiber development." [GOC:vk] synonym: "regulation of cardiac muscle fibre development" EXACT [] synonym: "regulation of heart muscle fiber development" EXACT [] is_a: GO:0060284 ! regulation of cell development is_a: GO:2000725 ! regulation of cardiac muscle cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0055013 ! regulates cardiac muscle cell development relationship: RO:0002211 GO:0055013 ! regulates cardiac muscle cell development [Term] id: GO:0055019 name: negative regulation of cardiac muscle fiber development namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cardiac muscle fiber development." [GOC:vk] synonym: "down regulation of cardiac muscle fiber development" EXACT [] synonym: "down-regulation of cardiac muscle fiber development" EXACT [] synonym: "downregulation of cardiac muscle fiber development" EXACT [] synonym: "inhibition of cardiac muscle fiber development" NARROW [] synonym: "negative regulation of cardiac muscle fibre development" EXACT [] synonym: "negative regulation of heart muscle fiber development" RELATED [] is_a: GO:0010721 ! negative regulation of cell development is_a: GO:0051154 ! negative regulation of striated muscle cell differentiation is_a: GO:0055018 ! regulation of cardiac muscle fiber development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0055013 ! negatively regulates cardiac muscle cell development relationship: RO:0002212 GO:0055013 ! negatively regulates cardiac muscle cell development [Term] id: GO:0055020 name: positive regulation of cardiac muscle fiber development namespace: biological_process def: "Any process that activates, maintains or increases the frequency, rate or extent of cardiac muscle fiber development." [GOC:vk] synonym: "activation of cardiac muscle fiber development" NARROW [] synonym: "positive regulation of cardiac muscle fibre development" EXACT [] synonym: "positive regulation of heart muscle fiber development" EXACT [] synonym: "stimulation of cardiac muscle fiber development" NARROW [] synonym: "up regulation of cardiac muscle fiber development" EXACT [] synonym: "up-regulation of cardiac muscle fiber development" EXACT [] synonym: "upregulation of cardiac muscle fiber development" EXACT [] is_a: GO:0010720 ! positive regulation of cell development is_a: GO:0055018 ! regulation of cardiac muscle fiber development is_a: GO:2000727 ! positive regulation of cardiac muscle cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0055013 ! positively regulates cardiac muscle cell development relationship: RO:0002213 GO:0055013 ! positively regulates cardiac muscle cell development [Term] id: GO:0055021 name: regulation of cardiac muscle tissue growth namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cardiac muscle growth." [GOC:vk] is_a: GO:0060420 ! regulation of heart growth intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0055017 ! regulates cardiac muscle tissue growth relationship: RO:0002211 GO:0055017 ! regulates cardiac muscle tissue growth [Term] id: GO:0055022 name: negative regulation of cardiac muscle tissue growth namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cardiac muscle growth." [GOC:vk] synonym: "down regulation of cardiac muscle growth" EXACT [] synonym: "down-regulation of cardiac muscle growth" EXACT [] synonym: "downregulation of cardiac muscle growth" EXACT [] synonym: "inhibition of cardiac muscle growth" NARROW [] synonym: "negative regulation of heart muscle growth" RELATED [] is_a: GO:0055021 ! regulation of cardiac muscle tissue growth is_a: GO:0061117 ! negative regulation of heart growth intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0055017 ! negatively regulates cardiac muscle tissue growth relationship: RO:0002212 GO:0055017 ! negatively regulates cardiac muscle tissue growth [Term] id: GO:0055023 name: positive regulation of cardiac muscle tissue growth namespace: biological_process def: "Any process that activates, maintains or increases the frequency, rate or extent of cardiac muscle growth." [GOC:vk] synonym: "activation of cardiac muscle growth" NARROW [] synonym: "positive regulation of heart muscle growth" EXACT [] synonym: "stimulation of cardiac muscle growth" NARROW [] synonym: "up regulation of cardiac muscle growth" EXACT [] synonym: "up-regulation of cardiac muscle growth" EXACT [] synonym: "upregulation of cardiac muscle growth" EXACT [] is_a: GO:0055021 ! regulation of cardiac muscle tissue growth is_a: GO:0060421 ! positive regulation of heart growth intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0055017 ! positively regulates cardiac muscle tissue growth relationship: RO:0002213 GO:0055017 ! positively regulates cardiac muscle tissue growth [Term] id: GO:0055024 name: regulation of cardiac muscle tissue development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cardiac muscle tissue development." [GOC:vk] synonym: "regulation of heart muscle development" EXACT [] is_a: GO:0016202 ! regulation of striated muscle tissue development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0048738 ! regulates cardiac muscle tissue development relationship: RO:0002211 GO:0048738 ! regulates cardiac muscle tissue development [Term] id: GO:0055025 name: positive regulation of cardiac muscle tissue development namespace: biological_process def: "Any process that activates, maintains or increases the frequency, rate or extent of cardiac muscle tissue development." [GOC:vk] synonym: "activation of cardiac muscle development" NARROW [] synonym: "positive regulation of heart muscle development" EXACT [] synonym: "stimulation of cardiac muscle development" NARROW [] synonym: "up regulation of cardiac muscle development" EXACT [] synonym: "up-regulation of cardiac muscle development" EXACT [] synonym: "upregulation of cardiac muscle development" EXACT [] is_a: GO:0045844 ! positive regulation of striated muscle tissue development is_a: GO:0055024 ! regulation of cardiac muscle tissue development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0048738 ! positively regulates cardiac muscle tissue development relationship: RO:0002213 GO:0048738 ! positively regulates cardiac muscle tissue development [Term] id: GO:0055026 name: negative regulation of cardiac muscle tissue development namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cardiac muscle tissue development." [GOC:vk] synonym: "down regulation of cardiac muscle development" EXACT [] synonym: "down-regulation of cardiac muscle development" EXACT [] synonym: "downregulation of cardiac muscle development" EXACT [] synonym: "inhibition of cardiac muscle development" NARROW [] synonym: "negative regulation of heart muscle development" EXACT [] is_a: GO:0045843 ! negative regulation of striated muscle tissue development is_a: GO:0055024 ! regulation of cardiac muscle tissue development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0048738 ! negatively regulates cardiac muscle tissue development relationship: RO:0002212 GO:0048738 ! negatively regulates cardiac muscle tissue development [Term] id: GO:0055056 name: D-glucose transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of the D-enantiomer of the hexose monosaccharide glucose from one side of a membrane to the other." [GOC:jid, GOC:jsg, GOC:mah] xref: Reactome:R-HSA-429094 "SLC2A6,8,10,12 transport Glc from extracellular region to cytosol" xref: Reactome:R-HSA-450095 "GLUT2 (SLC2A2) transports Glc from cytosol to extracellular region" xref: Reactome:R-HSA-499981 "Transport of Extracellular Glucose to the Cytosol by GLUT1 and GLUT2" xref: Reactome:R-HSA-5339524 "GLUT1 (SLC2A1) tetramer transports Glc from extracellular region to cytosol" xref: Reactome:R-HSA-5632804 "SLC2A1 tetramer does not transport Glc from extracellular region to cytosol" xref: Reactome:R-HSA-5632871 "Defective SLC2A10 does not transport Glc from extracellular region to cytosol" xref: Reactome:R-HSA-5653873 "SLC2A1 tetramer transports Glc from cytosol to Golgi lumen" xref: Reactome:R-HSA-8981553 "GLUT14 (SLC2A14) tetramer transports Glc from extracellular region to cytosol" xref: Reactome:R-HSA-8981564 "GLUT3 (SLC2A3) tetramer transports Glc from extracellular region to cytosol" xref: Reactome:R-HSA-8981570 "GLUT4 (SLC2A4) tetramer transports Glc from extracellular region to cytosol" xref: Reactome:R-HSA-8981574 "GLUT2 (SLC2A2) tetramer transports Glc from extracellular region to cytosol" is_a: GO:0015149 ! hexose transmembrane transporter activity intersection_of: GO:0022857 ! transmembrane transporter activity intersection_of: RO:0004009 CHEBI:4167 ! has primary input relationship: RO:0004009 CHEBI:4167 ! has primary input property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/27326" xsd:anyURI [Term] id: GO:0055057 name: neuroblast division namespace: biological_process def: "The process resulting in the physical partitioning and separation of a neuroblast into daughter cells. A neuroblast is any cell that will divide and give rise to a neuron." [PMID:11163136, PMID:11250167] synonym: "neuroblast cell division" EXACT [] is_a: BFO:0000003 is_a: GO:0051301 ! cell division intersection_of: GO:0051301 ! cell division intersection_of: RO:0004009 CL:0000031 ! has primary input neuroblast (sensu Vertebrata) relationship: BFO:0000050 GO:0007405 ! part of neuroblast proliferation relationship: RO:0004009 CL:0000031 ! has primary input neuroblast (sensu Vertebrata) [Term] id: GO:0055059 name: asymmetric neuroblast division namespace: biological_process def: "The process resulting in the physical partitioning and separation of a neuroblast into two daughter cells with different developmental potentials." [GOC:dph] is_a: GO:0008356 ! asymmetric cell division is_a: GO:0045165 ! cell fate commitment is_a: GO:0055057 ! neuroblast division intersection_of: GO:0008356 ! asymmetric cell division intersection_of: RO:0004009 CL:0000031 ! has primary input neuroblast (sensu Vertebrata) [Term] id: GO:0055062 name: phosphate ion homeostasis namespace: biological_process def: "Any process involved in the maintenance of an internal steady state of phosphate ions within an organism or cell." [GOC:jid, GOC:mah] synonym: "phosphate homeostasis" BROAD [] synonym: "Pi homeostasis" EXACT [] is_a: GO:0098771 ! inorganic ion homeostasis intersection_of: GO:0048878 ! chemical homeostasis intersection_of: RO:0002332 CHEBI:43474 ! regulates levels of relationship: RO:0002332 CHEBI:43474 ! regulates levels of property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/26429" xsd:anyURI [Term] id: GO:0055074 name: calcium ion homeostasis namespace: biological_process def: "Any process involved in the maintenance of an internal steady state of calcium ions within an organism or cell." [GOC:ceb, GOC:jid, GOC:mah] synonym: "regulation of calcium ion concentration" EXACT [] is_a: GO:0055080 ! monoatomic cation homeostasis is_a: GO:0098771 ! inorganic ion homeostasis intersection_of: GO:0048878 ! chemical homeostasis intersection_of: RO:0002332 CHEBI:29108 ! regulates levels of relationship: RO:0002332 CHEBI:29108 ! regulates levels of [Term] id: GO:0055075 name: potassium ion homeostasis namespace: biological_process def: "Any process involved in the maintenance of an internal steady state of potassium ions within an organism or cell." [GOC:jid, GOC:mah] is_a: GO:0055080 ! monoatomic cation homeostasis is_a: GO:0098771 ! inorganic ion homeostasis intersection_of: GO:0048878 ! chemical homeostasis intersection_of: RO:0002332 CHEBI:29103 ! regulates levels of relationship: RO:0002332 CHEBI:29103 ! regulates levels of [Term] id: GO:0055078 name: sodium ion homeostasis namespace: biological_process def: "Any process involved in the maintenance of an internal steady state of sodium ions within an organism or cell." [GOC:ai, GOC:jid, GOC:mah] is_a: GO:0055080 ! monoatomic cation homeostasis is_a: GO:0098771 ! inorganic ion homeostasis intersection_of: GO:0048878 ! chemical homeostasis intersection_of: RO:0002332 CHEBI:29101 ! regulates levels of relationship: RO:0002332 CHEBI:29101 ! regulates levels of [Term] id: GO:0055080 name: monoatomic cation homeostasis namespace: biological_process def: "Any process involved in the maintenance of an internal steady state of monoatomic cations within an organism or cell. Monatomic cations (also called simple cations) are cations consisting of exactly one atom." [GOC:ceb, GOC:jid, GOC:mah] synonym: "cation homeostasis" BROAD [] is_a: GO:0050801 ! monoatomic ion homeostasis intersection_of: GO:0048878 ! chemical homeostasis intersection_of: RO:0002332 CHEBI:23906 ! regulates levels of relationship: RO:0002332 CHEBI:23906 ! regulates levels of property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/24455" xsd:anyURI [Term] id: GO:0055082 name: intracellular chemical homeostasis namespace: biological_process def: "A homeostatic process involved in the maintenance of a steady state level of a chemical within a cell." [GOC:isa_complete, GOC:jid] synonym: "cellular chemical homeostasis" EXACT [] is_a: GO:0019725 ! cellular homeostasis is_a: GO:0048878 ! chemical homeostasis intersection_of: GO:0019725 ! cellular homeostasis intersection_of: RO:0002332 CHEBI:24431 ! regulates levels of property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/24514" xsd:anyURI [Term] id: GO:0055085 name: transmembrane transport namespace: biological_process def: "The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid] comment: Transmembrane transport is the transport of a solute across a lipid bilayer. Note that transport through the nuclear pore complex is not transmembrane because the nuclear membrane is a double membrane and is not traversed. For transport through the nuclear pore, consider instead the term 'nucleocytoplasmic transport ; GO:0006913' and its children. Note also that this term is not intended for use in annotating lateral movement within membranes. subset: goslim_chembl subset: goslim_drosophila subset: goslim_euk_cellular_processes_ribbon subset: goslim_generic subset: goslim_pombe subset: goslim_yeast synonym: "ATP hydrolysis coupled transmembrane transport" NARROW [] synonym: "membrane transport" EXACT [] xref: Reactome:R-HSA-382556 "ABC-family proteins mediated transport" xref: Reactome:R-HSA-425407 "SLC-mediated transmembrane transport" xref: Reactome:R-HSA-5223345 "Miscellaneous transport and binding events" is_a: BFO:0000003 is_a: GO:0006810 ! transport is_a: GO:0009987 ! cellular process intersection_of: GO:0006810 ! transport intersection_of: RO:0002342 GO:0016020 ! results in transport across membrane relationship: RO:0002342 GO:0016020 ! results in transport across membrane creation_date: 2015-10-21T13:22:47Z [Term] id: GO:0055086 name: nucleobase-containing small molecule metabolic process namespace: biological_process def: "The cellular chemical reactions and pathways involving a nucleobase-containing small molecule: a nucleobase, a nucleoside, or a nucleotide." [GOC:vw] subset: goslim_drosophila subset: goslim_generic subset: goslim_pombe subset: goslim_prokaryote subset: goslim_yeast synonym: "nucleobase, nucleoside and nucleotide metabolic process" RELATED [] synonym: "nucleobase, nucleoside and nucleotide metabolism" EXACT [] xref: Reactome:R-HSA-15869 "Metabolism of nucleotides" xref: Reactome:R-HSA-2393930 "Phosphate bond hydrolysis by NUDT proteins" is_a: GO:0006139 ! nucleobase-containing compound metabolic process is_a: GO:0044281 ! small molecule metabolic process [Term] id: GO:0055088 name: lipid homeostasis namespace: biological_process def: "Any process involved in the maintenance of an internal steady state of lipid within an organism or cell." [GOC:BHF, GOC:rl] is_a: GO:0048878 ! chemical homeostasis intersection_of: GO:0048878 ! chemical homeostasis intersection_of: RO:0002332 CHEBI:18059 ! regulates levels of relationship: RO:0002332 CHEBI:18059 ! regulates levels of [Term] id: GO:0055089 name: fatty acid homeostasis namespace: biological_process def: "Any process involved in the maintenance of an internal steady state of fatty acid within an organism or cell." [GOC:BHF, GOC:rl] is_a: GO:0055088 ! lipid homeostasis intersection_of: GO:0048878 ! chemical homeostasis intersection_of: RO:0002332 CHEBI:28868 ! regulates levels of relationship: RO:0002332 CHEBI:28868 ! regulates levels of [Term] id: GO:0055094 name: response to lipoprotein particle namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipoprotein particle stimulus." [GOC:BHF, GOC:rl] synonym: "response to lipoprotein particle stimulus" EXACT [GOC:dos] is_a: GO:0009719 ! response to endogenous stimulus is_a: GO:1901698 ! response to nitrogen compound intersection_of: GO:0050896 ! response to stimulus intersection_of: RO:0004009 CHEBI:6495 ! has primary input relationship: RO:0004009 CHEBI:6495 ! has primary input [Term] id: GO:0055107 name: Golgi to secretory granule transport namespace: biological_process def: "The directed movement of proteins from the Golgi to a secretory granule. The secretory granule is a membrane-bounded particle, usually protein, formed in the granular endoplasmic reticulum and the Golgi complex." [GOC:curators] is_a: GO:0046907 ! intracellular transport intersection_of: GO:0046907 ! intracellular transport intersection_of: RO:0002338 GO:0005794 ! has target start location Golgi apparatus intersection_of: RO:0002339 GO:0030141 ! has target end location secretory granule relationship: RO:0002338 GO:0005794 ! has target start location Golgi apparatus relationship: RO:0002339 GO:0030141 ! has target end location secretory granule [Term] id: GO:0055108 name: Golgi to transport vesicle transport namespace: biological_process def: "The directed movement of proteins from the Golgi to a transport vesicle. Continuously secreted proteins are sorted into transport vesicles that fuse with the plasma membrane, releasing their contents by exocytosis." [GOC:jid] is_a: GO:0046907 ! intracellular transport intersection_of: GO:0046907 ! intracellular transport intersection_of: RO:0002338 GO:0005794 ! has target start location Golgi apparatus intersection_of: RO:0002339 GO:0030133 ! has target end location transport vesicle relationship: BFO:0000050 GO:0048193 ! part of Golgi vesicle transport relationship: RO:0002338 GO:0005794 ! has target start location Golgi apparatus relationship: RO:0002339 GO:0030133 ! has target end location transport vesicle [Term] id: GO:0055111 name: ingression involved in gastrulation with mouth forming second namespace: biological_process def: "The migration of individual cells into the embryo involved in deuterostomic gastrulation." [ISBN:0878932437] is_a: GO:0042074 ! cell migration involved in gastrulation intersection_of: GO:0001667 ! ameboidal-type cell migration intersection_of: BFO:0000050 GO:0001702 ! part of gastrulation with mouth forming second relationship: BFO:0000050 GO:0001702 ! part of gastrulation with mouth forming second [Term] id: GO:0055117 name: regulation of cardiac muscle contraction namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cardiac muscle contraction." [GOC:ecd] is_a: GO:0006942 ! regulation of striated muscle contraction is_a: GO:0008016 ! regulation of heart contraction intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0060048 ! regulates cardiac muscle contraction relationship: RO:0002211 GO:0060048 ! regulates cardiac muscle contraction property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0055118 name: negative regulation of cardiac muscle contraction namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cardiac muscle contraction." [GOC:ecd] is_a: GO:0045822 ! negative regulation of heart contraction is_a: GO:0045988 ! negative regulation of striated muscle contraction is_a: GO:0055117 ! regulation of cardiac muscle contraction intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0060048 ! negatively regulates cardiac muscle contraction relationship: RO:0002212 GO:0060048 ! negatively regulates cardiac muscle contraction property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0055123 name: digestive system development namespace: biological_process def: "The process whose specific outcome is the progression of the digestive system over time, from its formation to the mature structure. The digestive system is the entire structure in which digestion takes place. Digestion is all of the physical, chemical, and biochemical processes carried out by multicellular organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism." [GOC:jid] is_a: GO:0048731 ! system development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0001007 ! results in development of digestive system relationship: RO:0002296 UBERON:0001007 ! results in development of digestive system property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0055127 name: vibrational conductance of sound to the inner ear namespace: biological_process def: "The transmission of vibrations via ossicles to the inner ear." [GOC:mh] is_a: GO:0032501 ! multicellular organismal process relationship: BFO:0000050 GO:0007605 ! part of sensory perception of sound creation_date: 2009-10-13T10:59:39Z [Term] id: GO:0060004 name: reflex namespace: biological_process def: "An automatic response to a stimulus beginning with a nerve impulse from a receptor and ending with the action of an effector such as a gland or a muscle. Signaling never reaches a level of consciousness." [GOC:dph, ISBN:0877797099] xref: Wikipedia:Reflex is_a: GO:0009605 ! response to external stimulus [Term] id: GO:0060005 name: vestibular reflex namespace: biological_process def: "A reflex process in which a response to an angular or linear acceleration stimulus begins with an afferent nerve impulse from a receptor in the inner ear and ends with the compensatory action of eye muscles. Signaling never reaches a level of consciousness." [PMID:11784757] is_a: GO:0060004 ! reflex [Term] id: GO:0060007 name: linear vestibuloocular reflex namespace: biological_process def: "A vestibular reflex by which a response to a linear acceleration stimulus begins with an afferent nerve impulse from a receptor in the otolith and ends with the compensatory action of eye muscles. Signaling never reaches a level of consciousness." [GOC:dph, PMID:11784757] is_a: GO:0060005 ! vestibular reflex [Term] id: GO:0060008 name: Sertoli cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized structural and/or functional features of a Sertoli cell. A Sertoli cell is a supporting cell projecting inward from the basement membrane of seminiferous tubules." [GOC:dph] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0030855 ! epithelial cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000216 ! results in acquisition of features of Sertoli cell relationship: BFO:0000050 GO:0008584 ! part of male gonad development relationship: RO:0002315 CL:0000216 ! results in acquisition of features of Sertoli cell [Term] id: GO:0060009 name: Sertoli cell development namespace: biological_process def: "The process whose specific outcome is the progression of a Sertoli cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a Sertoli cell fate." [GOC:dph] is_a: GO:0002064 ! epithelial cell development is_a: GO:0003006 ! developmental process involved in reproduction intersection_of: GO:0032502 ! developmental process intersection_of: RO:0002296 CL:0000216 ! results in development of Sertoli cell relationship: BFO:0000050 GO:0060008 ! part of Sertoli cell differentiation relationship: RO:0002296 CL:0000216 ! results in development of Sertoli cell [Term] id: GO:0060011 name: Sertoli cell proliferation namespace: biological_process def: "The multiplication or reproduction of Sertoli cells, resulting in the expansion of the Sertoli cell population. A Sertoli cell is a supporting cell projecting inward from the basement membrane of seminiferous tubules." [GOC:dph] is_a: GO:0050673 ! epithelial cell proliferation intersection_of: GO:0008283 ! cell population proliferation intersection_of: RO:0012003 CL:0000216 ! acts on population of Sertoli cell relationship: BFO:0000050 GO:0008584 ! part of male gonad development relationship: RO:0012003 CL:0000216 ! acts on population of Sertoli cell property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4751 [Term] id: GO:0060012 name: synaptic transmission, glycinergic namespace: biological_process def: "The vesicular release of glycine from a presynapse, across a chemical synapse, the subsequent activation of glycine receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse." [GOC:dos] synonym: "glycinergic synaptic transmission" EXACT [] is_a: GO:0007268 ! chemical synaptic transmission relationship: has_participant CHEBI:57305 [Term] id: GO:0060014 name: granulosa cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires the specialized features of a granulosa cell, a supporting cell for the developing female gamete in the ovary of mammals." [GOC:dph] is_a: GO:0030855 ! epithelial cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000501 ! results in acquisition of features of granulosa cell relationship: RO:0002315 CL:0000501 ! results in acquisition of features of granulosa cell [Term] id: GO:0060016 name: granulosa cell development namespace: biological_process def: "The process whose specific outcome is the progression of a granulosa cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a granulosa cell fate." [GOC:dph] is_a: GO:0002064 ! epithelial cell development intersection_of: GO:0032502 ! developmental process intersection_of: RO:0002296 CL:0000501 ! results in development of granulosa cell relationship: BFO:0000050 GO:0060014 ! part of granulosa cell differentiation relationship: RO:0002296 CL:0000501 ! results in development of granulosa cell [Term] id: GO:0060017 name: parathyroid gland development namespace: biological_process def: "The process whose specific outcome is the progression of the parathyroid gland over time, from its formation to the mature structure. The parathyroid gland is an organ specialised for secretion of parathyroid hormone." [GOC:dph, ISBN:0721662544] is_a: GO:0048732 ! gland development intersection_of: GO:0048732 ! gland development intersection_of: RO:0002296 UBERON:0001132 ! results in development of parathyroid gland relationship: BFO:0000050 GO:0035270 ! part of endocrine system development relationship: RO:0002296 UBERON:0001132 ! results in development of parathyroid gland [Term] id: GO:0060019 name: radial glial cell differentiation namespace: biological_process def: "The process in which neuroepithelial cells of the neural tube give rise to radial glial cells, specialized bipotential progenitors cells of the brain. Differentiation includes the processes involved in commitment of a cell to a specific fate." [GOC:dph] is_a: GO:0010001 ! glial cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000681 ! results in acquisition of features of radial glial cell relationship: RO:0002315 CL:0000681 ! results in acquisition of features of radial glial cell [Term] id: GO:0060020 name: Bergmann glial cell differentiation namespace: biological_process def: "The process in which neuroepithelial cells of the neural tube give rise to Brgmann glial cells, specialized bipotential progenitors cells of the cerebellum. Differentiation includes the processes involved in commitment of a cell to a specific fate." [GOC:dph, PMID:10375501] is_a: GO:0048708 ! astrocyte differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000644 ! results in acquisition of features of Bergmann glial cell relationship: RO:0002315 CL:0000644 ! results in acquisition of features of Bergmann glial cell [Term] id: GO:0060021 name: roof of mouth development namespace: biological_process def: "The biological process whose specific outcome is the progression of the roof of the mouth from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure. The roof of the mouth is the partition that separates the nasal and oral cavities." [GOC:dph, ISBN:0721662544] synonym: "palatum development" EXACT [ISBN:0721662544] is_a: GO:0048856 ! anatomical structure development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0007375 ! results in development of roof of mouth relationship: RO:0002296 UBERON:0007375 ! results in development of roof of mouth [Term] id: GO:0060034 name: notochord cell differentiation namespace: biological_process def: "The process in which relatively unspecialized cells acquire specialized structural and/or functional features cells that make up the notochord. Differentiation includes the processes involved in commitment of a cell to a notochord cell fate." [GOC:dph] is_a: GO:0030154 ! cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0007005 ! results in acquisition of features of notochordal cell relationship: BFO:0000050 GO:0030903 ! part of notochord development relationship: RO:0002315 CL:0007005 ! results in acquisition of features of notochordal cell [Term] id: GO:0060037 name: pharyngeal system development namespace: biological_process def: "The process whose specific outcome is the progression of the pharyngeal system over time, from its formation to the mature structure. The pharyngeal system is a transient embryonic complex that is specific to vertebrates. It comprises the pharyngeal arches, bulges of tissues of mesoderm and neural crest derivation through which pass nerves and pharyngeal arch arteries. The arches are separated internally by pharyngeal pouches, evaginations of foregut endoderm, and externally by pharyngeal clefts, invaginations of surface ectoderm. The development of the system ends when the structure it contributes to are forming: the thymus, thyroid, parathyroids, maxilla, mandible, aortic arch, cardiac outflow tract, external and middle ear." [GOC:dph] is_a: GO:0048731 ! system development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0008814 ! results in development of pharyngeal arch system relationship: BFO:0000050 GO:0043009 ! part of chordate embryonic development relationship: RO:0002296 UBERON:0008814 ! results in development of pharyngeal arch system [Term] id: GO:0060038 name: cardiac muscle cell proliferation namespace: biological_process def: "The expansion of a cardiac muscle cell population by cell division." [GOC:dph, GOC:rph, PMID:11161571] synonym: "cardiac myocyte proliferation" EXACT [] synonym: "cardiomyocyte proliferation" RELATED [GOC:dph, PMID:10074473] synonym: "heart muscle cell proliferation" EXACT [] is_a: GO:0014855 ! striated muscle cell proliferation intersection_of: GO:0008283 ! cell population proliferation intersection_of: RO:0012003 CL:0000746 ! acts on population of cardiac muscle cell relationship: BFO:0000050 GO:0055017 ! part of cardiac muscle tissue growth relationship: RO:0012003 CL:0000746 ! acts on population of cardiac muscle cell [Term] id: GO:0060039 name: pericardium development namespace: biological_process def: "The process whose specific outcome is the progression of the pericardium over time, from its formation to the mature structure. The pericardium is a double-walled sac that contains the heart and the roots of the aorta, vena cava and the pulmonary artery." [GOC:dph, GOC:rph, PMID:15138308, PMID:16376438] is_a: GO:0060429 ! epithelium development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0002407 ! results in development of pericardium relationship: BFO:0000050 GO:0007507 ! part of heart development relationship: RO:0002296 UBERON:0002407 ! results in development of pericardium [Term] id: GO:0060040 name: retinal bipolar neuron differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a bipolar cell, the last neuron to be generated in the retina." [GOC:ascb_2009, GOC:bf, GOC:dph, GOC:tb] is_a: GO:1905962 ! glutamatergic neuron differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000748 ! results in acquisition of features of retinal bipolar neuron relationship: BFO:0000050 GO:0003407 ! part of neural retina development relationship: BFO:0000050 GO:0060042 ! part of retina morphogenesis in camera-type eye relationship: RO:0002315 CL:0000748 ! results in acquisition of features of retinal bipolar neuron [Term] id: GO:0060041 name: retina development in camera-type eye namespace: biological_process def: "The process whose specific outcome is the progression of the retina over time, from its formation to the mature structure. The retina is the innermost layer or coating at the back of the eyeball, which is sensitive to light and in which the optic nerve terminates." [GOC:bf, GOC:dph, ISBN:0815340729] synonym: "retina development in camera-style eye" EXACT [] synonym: "retinal development" RELATED [GOC:dph, GOC:tb] is_a: GO:0048856 ! anatomical structure development intersection_of: GO:0048856 ! anatomical structure development intersection_of: BFO:0000050 GO:0043010 ! part of camera-type eye development intersection_of: RO:0002296 UBERON:0000966 ! results in development of retina relationship: BFO:0000050 GO:0043010 ! part of camera-type eye development relationship: RO:0002296 UBERON:0000966 ! results in development of retina [Term] id: GO:0060042 name: retina morphogenesis in camera-type eye namespace: biological_process def: "The process in which the anatomical structure of the retina is generated and organized." [GOC:bf, GOC:dph, GOC:mtg_sensu] synonym: "retina morphogenesis in camera-style eye" EXACT [] synonym: "retinogenesis" EXACT [] is_a: BFO:0000003 is_a: GO:0009653 ! anatomical structure morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0000966 ! results in morphogenesis of retina relationship: BFO:0000050 GO:0048593 ! part of camera-type eye morphogenesis relationship: BFO:0000050 GO:0060041 ! part of retina development in camera-type eye relationship: RO:0002298 UBERON:0000966 ! results in morphogenesis of retina [Term] id: GO:0060043 name: regulation of cardiac muscle cell proliferation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cardiac muscle cell proliferation." [GOC:dph, GOC:rph] synonym: "regulation of cardiomyocyte proliferation" RELATED [GOC:dph] synonym: "regulation of heart muscle cell proliferation" EXACT [] is_a: GO:0042127 ! regulation of cell population proliferation is_a: GO:0055021 ! regulation of cardiac muscle tissue growth intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0060038 ! regulates cardiac muscle cell proliferation relationship: RO:0002211 GO:0060038 ! regulates cardiac muscle cell proliferation [Term] id: GO:0060044 name: negative regulation of cardiac muscle cell proliferation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cardiac muscle cell proliferation." [GOC:dph, GOC:rph] synonym: "negative regulation of heart muscle cell proliferation" EXACT [] is_a: GO:0008285 ! negative regulation of cell population proliferation is_a: GO:0055022 ! negative regulation of cardiac muscle tissue growth is_a: GO:0060043 ! regulation of cardiac muscle cell proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0060038 ! negatively regulates cardiac muscle cell proliferation relationship: RO:0002212 GO:0060038 ! negatively regulates cardiac muscle cell proliferation [Term] id: GO:0060045 name: positive regulation of cardiac muscle cell proliferation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cardiac muscle cell proliferation." [GOC:dph, GOC:rph] synonym: "positive regulation of heart muscle cell proliferation" RELATED [] is_a: GO:0008284 ! positive regulation of cell population proliferation is_a: GO:0055023 ! positive regulation of cardiac muscle tissue growth is_a: GO:0060043 ! regulation of cardiac muscle cell proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0060038 ! positively regulates cardiac muscle cell proliferation relationship: RO:0002213 GO:0060038 ! positively regulates cardiac muscle cell proliferation [Term] id: GO:0060047 name: heart contraction namespace: biological_process def: "The multicellular organismal process in which the heart decreases in volume in a characteristic way to propel blood through the body." [GOC:dph] synonym: "cardiac contraction" RELATED [] synonym: "heart beating" EXACT [] synonym: "hemolymph circulation" RELATED [] is_a: GO:0003015 ! heart process relationship: BFO:0000050 GO:0008015 ! part of blood circulation property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0060048 name: cardiac muscle contraction namespace: biological_process def: "Muscle contraction of cardiac muscle tissue." [GOC:dph] synonym: "heart muscle contraction" EXACT [] is_a: GO:0006941 ! striated muscle contraction intersection_of: GO:0006936 ! muscle contraction intersection_of: BFO:0000066 UBERON:0001133 ! occurs in cardiac muscle tissue relationship: BFO:0000050 GO:0060047 ! part of heart contraction relationship: BFO:0000066 UBERON:0001133 ! occurs in cardiac muscle tissue property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0060054 name: positive regulation of epithelial cell proliferation involved in wound healing namespace: biological_process def: "Any process that activates or increases the rate or extent of epithelial cell proliferation, contributing to the restoration of integrity to a damaged tissue following an injury." [GOC:dph] is_a: GO:0050679 ! positive regulation of epithelial cell proliferation intersection_of: GO:0050679 ! positive regulation of epithelial cell proliferation intersection_of: BFO:0000050 GO:0042060 ! part of wound healing relationship: BFO:0000050 GO:0042060 ! part of wound healing property_value: RO:0002161 NCBITaxon:4751 [Term] id: GO:0060055 name: angiogenesis involved in wound healing namespace: biological_process def: "Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels and contribute to the series of events that restore integrity to a damaged tissue, following an injury." [GOC:dph, PMID:15039218] is_a: GO:0001525 ! angiogenesis intersection_of: GO:0001525 ! angiogenesis intersection_of: BFO:0000050 GO:0042060 ! part of wound healing relationship: BFO:0000050 GO:0042060 ! part of wound healing [Term] id: GO:0060065 name: uterus development namespace: biological_process def: "The reproductive developmental process whose specific outcome is the progression of the uterus over time, from its formation to the mature structure." [GOC:dph, GOC:ebc] synonym: "Mullerian tract development" RELATED [] is_a: GO:0048513 ! animal organ development is_a: GO:0048608 ! reproductive structure development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0000995 ! results in development of uterus relationship: RO:0002162 NCBITaxon:32525 ! in taxon Theria relationship: RO:0002296 UBERON:0000995 ! results in development of uterus [Term] id: GO:0060066 name: oviduct development namespace: biological_process def: "The reproductive developmental process whose specific outcome is the progression of an oviduct over time, from its formation to the mature structure. An oviduct is a tube through which an ova passes from the ovary to the uterus, or from the ovary to the outside of the organism." [GOC:dph, GOC:ebc, PMID:22918811, PMID:27875265] synonym: "fallopian tube development" NARROW [GOC:bf] synonym: "Mullerian tract development" RELATED [] is_a: GO:0035295 ! tube development is_a: GO:0048608 ! reproductive structure development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0003889 ! results in development of fallopian tube relationship: RO:0002162 NCBITaxon:40674 ! in taxon Mammalia relationship: RO:0002296 UBERON:0003889 ! results in development of fallopian tube [Term] id: GO:0060067 name: cervix development namespace: biological_process def: "The reproductive developmental process whose specific outcome is the progression of the cervix over time, from its formation to the mature structure." [GOC:dph, GOC:ebc] synonym: "Mullerian tract development" RELATED [] is_a: GO:0048608 ! reproductive structure development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0000002 ! results in development of uterine cervix relationship: RO:0002162 NCBITaxon:32525 ! in taxon Theria relationship: RO:0002296 UBERON:0000002 ! results in development of uterine cervix [Term] id: GO:0060068 name: vagina development namespace: biological_process def: "The reproductive developmental process whose specific outcome is the progression of the vagina over time, from its formation to the mature structure." [GOC:dph, GOC:ebc] is_a: GO:0030540 ! female genitalia development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0000996 ! results in development of vagina relationship: RO:0002296 UBERON:0000996 ! results in development of vagina [Term] id: GO:0060073 name: micturition namespace: biological_process def: "The regulation of body fluids process in which parasympathetic nerves stimulate the bladder wall muscle to contract and expel urine from the body." [GOC:dph] synonym: "urination" EXACT [] synonym: "urine voiding" EXACT [] xref: Wikipedia:Urination is_a: GO:0003014 ! renal system process is_a: GO:0007588 ! excretion property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0060076 name: excitatory synapse namespace: cellular_component def: "A synapse in which an action potential in the presynaptic cell increases the probability of an action potential occurring in the postsynaptic cell." [GOC:dph, GOC:ef] xref: Wikipedia:Excitatory_synapse is_a: GO:0045202 ! synapse intersection_of: GO:0045202 ! synapse intersection_of: RO:0002215 GO:0098976 ! capable of excitatory chemical synaptic transmission relationship: RO:0002215 GO:0098976 ! capable of excitatory chemical synaptic transmission [Term] id: GO:0060078 name: regulation of postsynaptic membrane potential namespace: biological_process def: "Any process that modulates the potential difference across a post-synaptic membrane." [GOC:dph, GOC:ef] subset: goslim_synapse synonym: "regulation of post-synaptic membrane potential" EXACT [] is_a: GO:0042391 ! regulation of membrane potential [Term] id: GO:0060079 name: excitatory postsynaptic potential namespace: biological_process def: "A process that leads to a temporary increase in postsynaptic potential due to the flow of positively charged ions into the postsynaptic cell. The flow of ions that causes an EPSP is an excitatory postsynaptic current (EPSC) and makes it easier for the neuron to fire an action potential." [GOC:dph, GOC:ef] synonym: "regulation of EPSP" RELATED [] synonym: "regulation of excitatory post-synaptic membrane potential" EXACT [] is_a: GO:0060078 ! regulation of postsynaptic membrane potential relationship: BFO:0000050 GO:0099565 ! part of chemical synaptic transmission, postsynaptic [Term] id: GO:0060082 name: eye blink reflex namespace: biological_process def: "The reflex process in which a mechanical stimulus applied to the eye elicits a response of the eyelid closing." [GOC:dph, PMID:2913208] synonym: "nictitating membrane reflex" EXACT [] is_a: GO:0060004 ! reflex [Term] id: GO:0060083 name: smooth muscle contraction involved in micturition namespace: biological_process def: "The process leading to shortening and/or development of tension in the urinary bladder smooth muscle tissue involved in the expulsion urine from the body." [GOC:dph, PMID:15827347] synonym: "smooth muscle contraction involved in urination" RELATED [] synonym: "urinary bladder smooth muscle contraction involved in micturition" RELATED [GOC:dph] is_a: GO:0014832 ! urinary bladder smooth muscle contraction intersection_of: GO:0006939 ! smooth muscle contraction intersection_of: BFO:0000050 GO:0060073 ! part of micturition relationship: BFO:0000050 GO:0060073 ! part of micturition property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 property_value: RO:0002161 NCBITaxon:8782 [Term] id: GO:0060084 name: synaptic transmission involved in micturition namespace: biological_process def: "The process of communication from a neuron to a smooth muscle in the bladder that contributes to the expulsion of urine from the body." [GOC:dph, PMID:15827347] synonym: "synaptic transmission involved in urination" RELATED [] is_a: GO:0007274 ! neuromuscular synaptic transmission intersection_of: GO:0007268 ! chemical synaptic transmission intersection_of: BFO:0000050 GO:0060073 ! part of micturition relationship: BFO:0000050 GO:0060073 ! part of micturition [Term] id: GO:0060089 name: molecular transducer activity namespace: molecular_function def: "A compound molecular function in which an effector function is controlled by one or more regulatory components." [GOC:dos, GOC:pdt] subset: gocheck_do_not_annotate subset: goslim_generic subset: goslim_pir subset: goslim_prokaryote is_a: GO:0003674 ! molecular_function [Term] id: GO:0060090 name: molecular adaptor activity namespace: molecular_function def: "The binding activity of a molecule that brings together two or more molecules through a selective, non-covalent, often stoichiometric interaction, permitting those molecules to function in a coordinated way." [GOC:mtg_MIT_16mar07, GOC:vw] subset: goslim_drosophila subset: goslim_euk_cellular_processes_ribbon subset: goslim_generic subset: goslim_pir subset: goslim_plant_ribbon subset: goslim_prokaryote subset: goslim_prokaryote_ribbon synonym: "binding, bridging" EXACT [] synonym: "protein complex scaffold activity" BROAD [] synonym: "protein-containing complex scaffold activity" BROAD [] xref: Reactome:R-HSA-2564826 "4Fe-4S cluster assembles on NUBP2:NUBP1 scaffold" is_a: GO:0003674 ! molecular_function relationship: BFO:0000051 GO:0005488 ! has part binding [Term] id: GO:0060092 name: regulation of synaptic transmission, glycinergic namespace: biological_process def: "Any process that modulates the frequency, rate or extent of glycinergic synaptic transmission. Glycinergic synaptic transmission is the process of communication from a neuron to another neuron across a synapse using the neurotransmitter glycine." [GOC:dms, GOC:dph] is_a: GO:0050804 ! modulation of chemical synaptic transmission intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0060012 ! regulates synaptic transmission, glycinergic relationship: RO:0002211 GO:0060012 ! regulates synaptic transmission, glycinergic [Term] id: GO:0060093 name: negative regulation of synaptic transmission, glycinergic namespace: biological_process def: "Any process that stops or decreases the frequency, rate or extent of glycinergic synaptic transmission. Glycinergic synaptic transmission is the process of communication from a neuron to another neuron across a synapse using the neurotransmitter glycine." [GOC:dms, GOC:dph] synonym: "negative regulation of glycinergic synaptic transmission" EXACT [] is_a: GO:0050805 ! negative regulation of synaptic transmission is_a: GO:0060092 ! regulation of synaptic transmission, glycinergic intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0060012 ! negatively regulates synaptic transmission, glycinergic relationship: RO:0002212 GO:0060012 ! negatively regulates synaptic transmission, glycinergic [Term] id: GO:0060094 name: positive regulation of synaptic transmission, glycinergic namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of glycinergic synaptic transmission. Glycinergic synaptic transmission is the process of communication from a neuron to another neuron across a synapse using the neurotransmitter glycine." [GOC:dms, GOC:dph] synonym: "positive regulation of glycinergic synaptic transmission" EXACT [] is_a: GO:0050806 ! positive regulation of synaptic transmission is_a: GO:0060092 ! regulation of synaptic transmission, glycinergic intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0060012 ! positively regulates synaptic transmission, glycinergic relationship: RO:0002213 GO:0060012 ! positively regulates synaptic transmission, glycinergic [Term] id: GO:0060096 name: serotonin secretion, neurotransmission namespace: biological_process def: "The regulated release of serotonin by a cell, in which released serotonin acts as a neurotransmitter." [GOC:dph] synonym: "serotonin release, neurotransmission" RELATED [GOC:tb] is_a: GO:0001820 ! serotonin secretion is_a: GO:0007269 ! neurotransmitter secretion intersection_of: GO:0007269 ! neurotransmitter secretion intersection_of: RO:0004009 CHEBI:350546 ! has primary input [Term] id: GO:0060113 name: inner ear receptor cell differentiation namespace: biological_process def: "The process in which relatively unspecialized cells, acquire specialized structural and/or functional features of inner ear receptor cells. Inner ear receptor cells are mechanorecptors found in the inner ear responsible for transducing signals involved in balance and sensory perception of sound." [GOC:dph] synonym: "inner ear hair cell differentiation" EXACT [] is_a: GO:0042490 ! mechanoreceptor differentiation relationship: BFO:0000050 GO:0048839 ! part of inner ear development [Term] id: GO:0060114 name: vestibular receptor cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a vestibular hair cell." [GOC:dph] synonym: "vestibular hair cell differentiation" EXACT [] is_a: GO:0035315 ! hair cell differentiation is_a: GO:0060113 ! inner ear receptor cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000609 ! results in acquisition of features of vestibular hair cell relationship: RO:0002315 CL:0000609 ! results in acquisition of features of vestibular hair cell [Term] id: GO:0060116 name: vestibular receptor cell morphogenesis namespace: biological_process def: "Any process that alters the size or shape of a vestibular receptor cell." [GOC:dph, GOC:tb] synonym: "vestibular hair cell morphogenesis" EXACT [] is_a: GO:0048598 ! embryonic morphogenesis is_a: GO:0048667 ! cell morphogenesis involved in neuron differentiation intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 CL:0000609 ! results in morphogenesis of vestibular hair cell relationship: BFO:0000050 GO:0042472 ! part of inner ear morphogenesis relationship: BFO:0000050 GO:0060118 ! part of vestibular receptor cell development relationship: RO:0002298 CL:0000609 ! results in morphogenesis of vestibular hair cell [Term] id: GO:0060117 name: auditory receptor cell development namespace: biological_process def: "The process whose specific outcome is the progression of an auditory receptor cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate." [GOC:dph] synonym: "auditory hair cell development" EXACT [] is_a: GO:0060119 ! inner ear receptor cell development intersection_of: GO:0032502 ! developmental process intersection_of: RO:0002296 CL:0000202 ! results in development of auditory hair cell relationship: BFO:0000050 GO:0042491 ! part of inner ear auditory receptor cell differentiation relationship: RO:0002296 CL:0000202 ! results in development of auditory hair cell [Term] id: GO:0060118 name: vestibular receptor cell development namespace: biological_process def: "The process whose specific outcome is the progression of a vestibular receptor cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate." [GOC:dph] synonym: "vestibular hair cell development" EXACT [] is_a: GO:0060119 ! inner ear receptor cell development intersection_of: GO:0032502 ! developmental process intersection_of: RO:0002296 CL:0000609 ! results in development of vestibular hair cell relationship: BFO:0000050 GO:0060114 ! part of vestibular receptor cell differentiation relationship: RO:0002296 CL:0000609 ! results in development of vestibular hair cell [Term] id: GO:0060119 name: inner ear receptor cell development namespace: biological_process def: "The process whose specific outcome is the progression of an inner ear receptor cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate." [GOC:dph] synonym: "inner ear hair cell development" EXACT [] is_a: GO:0048666 ! neuron development relationship: BFO:0000050 GO:0060113 ! part of inner ear receptor cell differentiation [Term] id: GO:0060123 name: regulation of growth hormone secretion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the regulated release of growth hormone from a cell." [GOC:dph] is_a: GO:0090276 ! regulation of peptide hormone secretion intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0030252 ! regulates growth hormone secretion relationship: RO:0002211 GO:0030252 ! regulates growth hormone secretion [Term] id: GO:0060124 name: positive regulation of growth hormone secretion namespace: biological_process def: "Any process that increases the frequency, rate or extent of the regulated release of growth hormone from a cell." [GOC:dph] is_a: GO:0060123 ! regulation of growth hormone secretion is_a: GO:0090277 ! positive regulation of peptide hormone secretion intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0030252 ! positively regulates growth hormone secretion relationship: RO:0002213 GO:0030252 ! positively regulates growth hormone secretion [Term] id: GO:0060125 name: negative regulation of growth hormone secretion namespace: biological_process def: "Any process that decreases or stops the frequency, rate or extent of the regulated release of growth hormone from a cell." [GOC:dph] is_a: GO:0060123 ! regulation of growth hormone secretion is_a: GO:0090278 ! negative regulation of peptide hormone secretion intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0030252 ! negatively regulates growth hormone secretion relationship: RO:0002212 GO:0030252 ! negatively regulates growth hormone secretion [Term] id: GO:0060126 name: somatotropin secreting cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized structural and/or functional features of a somatotropin secreting cell. A somatotropin secreting cell is an acidophilic cell of the anterior pituitary that produces growth hormone, somatotropin." [GOC:dph] synonym: "growth hormone secreting cell differentiation" EXACT [] synonym: "somatotrope differentiation" RELATED [] synonym: "somatotroph differentiation" RELATED [] synonym: "somatotrophin secreting cell differentiation" EXACT [] synonym: "somatotropic cell differentiation" RELATED [] synonym: "somatrophic cell differentiation" RELATED [] is_a: GO:0030154 ! cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000295 ! results in acquisition of features of somatotropin secreting cell relationship: BFO:0000050 GO:0021984 ! part of adenohypophysis development relationship: RO:0002315 CL:0000295 ! results in acquisition of features of somatotropin secreting cell [Term] id: GO:0060127 name: prolactin secreting cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized structural and/or functional features of a prolactin secreting cell. A prolactin secreting cell is an acidophilic cell of the anterior pituitary that produces prolactin." [GOC:dph] synonym: "epsilon-acidophil differentiation" EXACT [] synonym: "lactotrope differentiation" EXACT [] synonym: "lactotroph differentiation" EXACT [] synonym: "lactotropic cell differentiation" EXACT [] synonym: "mammotrope differentiation" EXACT [] synonym: "mammotroph differentiation" EXACT [] synonym: "mammotrophic cell differentiation" EXACT [] synonym: "mammotropic cell differentiation" EXACT [] is_a: GO:0030154 ! cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000439 ! results in acquisition of features of prolactin secreting cell relationship: BFO:0000050 GO:0021984 ! part of adenohypophysis development relationship: RO:0002315 CL:0000439 ! results in acquisition of features of prolactin secreting cell [Term] id: GO:0060128 name: corticotropin hormone secreting cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized structural and/or functional features of a corticotropic hormone secreting cell. An corticotropic hormone secreting cell is a basophil cell of the anterior pituitary that produces corticotropin." [GOC:dph] synonym: "adrenocorticotrophic hormone secreting cell differentiation" EXACT [] synonym: "adrenocorticotropic hormone secreting cell differentiation" EXACT [GOC:dph] synonym: "corticotrope differentiation" EXACT [] synonym: "corticotroph differentiation" EXACT [] synonym: "corticotrophin hormone secreting cell differentiation" RELATED [] is_a: GO:0030154 ! cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000467 ! results in acquisition of features of adrenocorticotropic hormone secreting cell relationship: BFO:0000050 GO:0021984 ! part of adenohypophysis development relationship: RO:0002315 CL:0000467 ! results in acquisition of features of adrenocorticotropic hormone secreting cell [Term] id: GO:0060129 name: thyroid-stimulating hormone-secreting cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized structural and/or functional features of a thyroid-stimulating hormone-secreting cell. A thyroid-stimulating hormone-secreting cell is a basophil cell of the anterior pituitary that produces thyroid-stimulating hormone, thyrotrophin." [GOC:dph] synonym: "beta-basophil differentiation" EXACT [] synonym: "thyroid stimulating hormone secreting cell differentiation" EXACT [] synonym: "thyrotrope differentiation" EXACT [] synonym: "thyrotroph differentiation" EXACT [] synonym: "TSH-secreting cell differentiation" EXACT [] is_a: GO:0002067 ! glandular epithelial cell differentiation is_a: GO:0021879 ! forebrain neuron differentiation is_a: GO:0061101 ! neuroendocrine cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000476 ! results in acquisition of features of thyrotroph relationship: BFO:0000050 GO:0021984 ! part of adenohypophysis development relationship: RO:0002315 CL:0000476 ! results in acquisition of features of thyrotroph [Term] id: GO:0060130 name: thyroid-stimulating hormone-secreting cell development namespace: biological_process def: "The process whose specific outcome is the progression of a thyroid-stimulating hormone-secreting cell over time, from its formation to the mature structure. A thyroid-stimulating hormone-secreting cell is a basophil cell of the anterior pituitary that produces thyroid stimulating hormone, thyrotrophin." [GOC:dph] synonym: "beta-basophil development" EXACT [] synonym: "thyroid stimulating hormone secreting cell development" EXACT [] synonym: "thyrotrope development" EXACT [] synonym: "thyrotroph development" EXACT [] synonym: "TSH-secreting cell development" EXACT [] is_a: GO:0002068 ! glandular epithelial cell development is_a: GO:0021884 ! forebrain neuron development intersection_of: GO:0032502 ! developmental process intersection_of: RO:0002296 CL:0000476 ! results in development of thyrotroph relationship: BFO:0000050 GO:0060129 ! part of thyroid-stimulating hormone-secreting cell differentiation relationship: RO:0002296 CL:0000476 ! results in development of thyrotroph [Term] id: GO:0060131 name: corticotropin hormone secreting cell development namespace: biological_process def: "The process whose specific outcome is the progression of a corticotropic hormone secreting cell over time, from its formation to the mature structure. An corticotropic hormone secreting cell is a basophil cell of the anterior pituitary that produces corticotropin." [GOC:dph] synonym: "adrenocorticotrophic hormone secreting cell development" EXACT [] synonym: "adrenocorticotropic hormone secreting cell development" EXACT [GOC:dph] synonym: "corticotrope development" EXACT [] synonym: "corticotroph development" RELATED [] synonym: "corticotrophin hormone secreting cell development" RELATED [] is_a: GO:0048468 ! cell development intersection_of: GO:0032502 ! developmental process intersection_of: RO:0002296 CL:0000467 ! results in development of adrenocorticotropic hormone secreting cell relationship: BFO:0000050 GO:0060128 ! part of corticotropin hormone secreting cell differentiation relationship: RO:0002296 CL:0000467 ! results in development of adrenocorticotropic hormone secreting cell [Term] id: GO:0060132 name: prolactin secreting cell development namespace: biological_process def: "The process whose specific outcome is the progression of a prolactin secreting cell over time, from its formation to the mature structure. A prolactin secreting cell is an acidophilic cell of the anterior pituitary that produces prolactin." [GOC:dph] synonym: "epsilon-acidophil development" EXACT [] synonym: "lactotrope development" EXACT [] synonym: "lactotroph development" EXACT [] synonym: "lactotropic cell development" EXACT [] synonym: "mammotrope development" EXACT [] synonym: "mammotroph development" EXACT [] synonym: "mammotrophic cell development" EXACT [] synonym: "mammotropic cell development" EXACT [] is_a: GO:0048468 ! cell development intersection_of: GO:0032502 ! developmental process intersection_of: RO:0002296 CL:0000439 ! results in development of prolactin secreting cell relationship: BFO:0000050 GO:0060127 ! part of prolactin secreting cell differentiation relationship: RO:0002296 CL:0000439 ! results in development of prolactin secreting cell [Term] id: GO:0060133 name: somatotropin secreting cell development namespace: biological_process def: "The process whose specific outcome is the progression of a somatotropin secreting cell over time, from its formation to the mature structure. A somatotropin secreting cell is an acidophilic cell of the anterior pituitary that produces growth hormone, somatotropin." [GOC:dph] synonym: "growth hormone secreting cell development" EXACT [] synonym: "somatotrope development" RELATED [] synonym: "somatotroph development" RELATED [] synonym: "somatotrophin secreting cell development" EXACT [] synonym: "somatotropic cell development" EXACT [] synonym: "somatrophic cell development" RELATED [] is_a: GO:0048468 ! cell development intersection_of: GO:0032502 ! developmental process intersection_of: RO:0002296 CL:0000295 ! results in development of somatotropin secreting cell relationship: BFO:0000050 GO:0060126 ! part of somatotropin secreting cell differentiation relationship: RO:0002296 CL:0000295 ! results in development of somatotropin secreting cell [Term] id: GO:0060135 name: maternal process involved in female pregnancy namespace: biological_process def: "A reproductive process occurring in the mother that allows an embryo or fetus to develop within it." [GOC:dph] is_a: GO:0048609 ! multicellular organismal reproductive process relationship: BFO:0000050 GO:0007565 ! part of female pregnancy [Term] id: GO:0060136 name: embryonic process involved in female pregnancy namespace: biological_process def: "A reproductive process occurring in the embryo or fetus that allows the embryo or fetus to develop within the mother." [GOC:dph] is_a: GO:0048609 ! multicellular organismal reproductive process intersection_of: GO:0022414 ! reproductive process intersection_of: BFO:0000050 GO:0007565 ! part of female pregnancy intersection_of: BFO:0000050 GO:0009790 ! part of embryo development relationship: BFO:0000050 GO:0007565 ! part of female pregnancy relationship: BFO:0000050 GO:0009792 ! part of embryo development ending in birth or egg hatching [Term] id: GO:0060142 name: regulation of syncytium formation by plasma membrane fusion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the formation of a syncytium, a mass of cytoplasm containing several nuclei enclosed within a single plasma membrane, by the fusion of the plasma membranes of two or more individual cells." [GOC:dph] is_a: GO:0050793 ! regulation of developmental process is_a: GO:0051128 ! regulation of cellular component organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0000768 ! regulates syncytium formation by plasma membrane fusion relationship: RO:0002211 GO:0000768 ! regulates syncytium formation by plasma membrane fusion [Term] id: GO:0060143 name: positive regulation of syncytium formation by plasma membrane fusion namespace: biological_process def: "Any process that increases the frequency, rate or extent of the formation of a syncytium, a mass of cytoplasm containing several nuclei enclosed within a single plasma membrane, by the fusion of the plasma membranes of two or more individual cells." [GOC:dph] is_a: GO:0051094 ! positive regulation of developmental process is_a: GO:0051130 ! positive regulation of cellular component organization is_a: GO:0060142 ! regulation of syncytium formation by plasma membrane fusion intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0000768 ! positively regulates syncytium formation by plasma membrane fusion relationship: RO:0002213 GO:0000768 ! positively regulates syncytium formation by plasma membrane fusion [Term] id: GO:0060156 name: milk ejection reflex namespace: biological_process def: "A reflex that occurs in response to suckling, beginning with a nerve impulse from a receptor in the mammary gland and ending with the ejection of milk from the gland. Signaling never reaches a level of consciousness." [GOC:cjm, GOC:dph, GOC:mr, GOC:st] synonym: "milk ejection" EXACT [] is_a: GO:0007589 ! body fluid secretion is_a: GO:0032941 ! secretion by tissue is_a: GO:0060004 ! reflex relationship: BFO:0000050 GO:0007595 ! part of lactation [Term] id: GO:0060157 name: urinary bladder development namespace: biological_process def: "The process whose specific outcome is the progression of the urinary bladder over time, from its formation to the mature structure. The urinary bladder is an elastic, muscular sac situated in the anterior part of the pelvic cavity in which urine collects before excretion." [GOC:dph, GOC:ln, GOC:mr, PMID:11768524, PMID:18276178, PMID:538956] is_a: GO:0048513 ! animal organ development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0001255 ! results in development of urinary bladder relationship: BFO:0000050 GO:0072001 ! part of renal system development relationship: RO:0002296 UBERON:0001255 ! results in development of urinary bladder property_value: RO:0002161 NCBITaxon:8782 [Term] id: GO:0060166 name: olfactory pit development namespace: biological_process def: "The biological process whose specific outcome is the progression of the olfactory pit from an initial condition to its mature state. This process begins with the formation of the olfactory pit, which is an indentation of the olfactory placode, and ends when the pits hollows out to form the nasopharynx." [GOC:dph, ISBN:0124020607] is_a: GO:0048856 ! anatomical structure development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0005870 ! results in development of olfactory pit relationship: BFO:0000050 GO:0043584 ! part of nose development relationship: RO:0002296 UBERON:0005870 ! results in development of olfactory pit property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/22589" xsd:anyURI [Term] id: GO:0060170 name: ciliary membrane namespace: cellular_component def: "The portion of the plasma membrane surrounding a cilium." [GOC:cilia, GOC:dph, GOC:rph] comment: Note that cilia and eukaryotic flagella are deemed to be equivalent. synonym: "cilial membrane" EXACT [] synonym: "cilium membrane" EXACT [] synonym: "flagellar membrane" NARROW [] synonym: "flagellum membrane" NARROW [] is_a: GO:0031253 ! cell projection membrane is_a: GO:0098588 ! bounding membrane of organelle intersection_of: GO:0016020 ! membrane intersection_of: RO:0002007 GO:0005929 ! bounding layer of cilium relationship: RO:0002007 GO:0005929 ! bounding layer of cilium property_value: RO:0002161 NCBITaxon:3176 property_value: RO:0002161 NCBITaxon:3378 property_value: RO:0002161 NCBITaxon:3398 property_value: RO:0002161 NCBITaxon:4890 property_value: RO:0002161 NCBITaxon:5782 [Term] id: GO:0060173 name: limb development namespace: biological_process def: "The process whose specific outcome is the progression of a limb over time, from its formation to the mature structure. A limb is an appendage of an animal used for locomotion or grasping. Examples include legs, arms or some types of fin." [GOC:dgh, GOC:dph, PMID:11487378] synonym: "limb bud development" NARROW [GOC:dph] synonym: "paired limb/fin development" EXACT [] xref: Wikipedia:Limb_development is_a: GO:0048736 ! appendage development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0004708 ! results in development of paired limb/fin relationship: RO:0002296 UBERON:0004708 ! results in development of paired limb/fin [Term] id: GO:0060174 name: limb bud formation namespace: biological_process def: "The process pertaining to the initial formation of a limb bud from unspecified parts. This process begins with the formation of a local condensation of mesenchyme cells within the prospective limb field, and ends when a limb bud is recognizable." [GOC:dgh, GOC:dph] synonym: "limb formation" EXACT [] synonym: "limbbud formation" EXACT [] is_a: BFO:0000003 is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0002101 ! results in formation of anatomical entity limb relationship: BFO:0000050 GO:0035108 ! part of limb morphogenesis relationship: RO:0002297 UBERON:0002101 ! results in formation of anatomical entity limb [Term] id: GO:0060214 name: endocardium formation namespace: biological_process def: "Formation of the endocardium of the heart. The endocardium is an anatomical structure comprised of an endothelium and an extracellular matrix that forms the innermost layer of tissue of the heart, and lines the heart chambers." [GOC:bf, GOC:dph, PMID:17722983] is_a: BFO:0000003 is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0002165 ! results in formation of anatomical entity endocardium relationship: BFO:0000050 GO:0003160 ! part of endocardium morphogenesis relationship: RO:0002297 UBERON:0002165 ! results in formation of anatomical entity endocardium [Term] id: GO:0060215 name: primitive hemopoiesis namespace: biological_process def: "A first transient wave of blood cell production that, in vertebrates, gives rise to erythrocytes (red blood cells) and myeloid cells." [GOC:bf, GOC:dph, PMID:15378083, PMID:15617691] synonym: "primitive haematopoiesis" EXACT [] synonym: "primitive haemopoiesis" EXACT [] synonym: "primitive hematopoiesis" RELATED [] is_a: GO:0035162 ! embryonic hemopoiesis [Term] id: GO:0060217 name: hemangioblast cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires the characteristics of a mature hemangioblast. Hemangioblasts are the proposed common precursor of blood and endothelial lineages." [GOC:bf, GOC:dph, PMID:15378083, PMID:9670018] is_a: GO:0048333 ! mesodermal cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0002418 ! results in acquisition of features of hemangioblast relationship: BFO:0000050 GO:0060215 ! part of primitive hemopoiesis relationship: RO:0002315 CL:0002418 ! results in acquisition of features of hemangioblast [Term] id: GO:0060218 name: hematopoietic stem cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a hematopoietic stem cell. A stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells." [GOC:bf, GOC:BHF, GOC:dph, GOC:rl, PMID:15378083] synonym: "haematopoietic stem cell differentiation" EXACT [] synonym: "haemopoietic stem cell differentiation" EXACT [] synonym: "hemopoietic stem cell differentiation" EXACT [] is_a: GO:0002244 ! hematopoietic progenitor cell differentiation is_a: GO:0048863 ! stem cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000037 ! results in acquisition of features of hematopoietic stem cell relationship: RO:0002315 CL:0000037 ! results in acquisition of features of hematopoietic stem cell [Term] id: GO:0060219 name: camera-type eye photoreceptor cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires the specialized features of a photoreceptor cell in a camera-type eye." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0001754 ! eye photoreceptor cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0010009 ! results in acquisition of features of camera-type eye photoreceptor cell relationship: BFO:0000050 GO:0003407 ! part of neural retina development relationship: BFO:0000050 GO:0060042 ! part of retina morphogenesis in camera-type eye relationship: RO:0002315 CL:0010009 ! results in acquisition of features of camera-type eye photoreceptor cell [Term] id: GO:0060221 name: retinal rod cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires the specialized features of a retinal rod cell." [GOC:dph] is_a: GO:0060219 ! camera-type eye photoreceptor cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000604 ! results in acquisition of features of retinal rod cell relationship: RO:0002315 CL:0000604 ! results in acquisition of features of retinal rod cell [Term] id: GO:0060231 name: mesenchymal to epithelial transition namespace: biological_process def: "A transition where a mesenchymal cell establishes apical/basolateral polarity, forms intercellular adhesive junctions, synthesizes basement membrane components and becomes an epithelial cell." [GOC:ascb_2009, GOC:dph, GOC:tb] synonym: "epithelial cell differentiation from mesenchymal cell" EXACT [GOC:BHF, GOC:dph, GOC:rl] synonym: "mesenchymal-epithelial transition" EXACT [GOC:dph] is_a: GO:0030855 ! epithelial cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000066 ! results in acquisition of features of epithelial cell intersection_of: RO:0004009 CL:0008019 ! has primary input mesenchymal cell relationship: RO:0004009 CL:0008019 ! has primary input mesenchymal cell [Term] id: GO:0060249 name: anatomical structure homeostasis namespace: biological_process def: "A homeostatic process involved in the maintenance of an internal steady state within a defined anatomical structure of an organism, including control of cellular proliferation and death and control of metabolic function. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome." [GOC:dph] synonym: "anatomical structure maintenance" EXACT [GOC:dph] is_a: GO:0048871 ! multicellular organismal-level homeostasis property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0060251 name: regulation of glial cell proliferation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of glial cell proliferation." [GOC:dph, GOC:tb] is_a: GO:0042127 ! regulation of cell population proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0014009 ! regulates glial cell proliferation relationship: RO:0002211 GO:0014009 ! regulates glial cell proliferation [Term] id: GO:0060252 name: positive regulation of glial cell proliferation namespace: biological_process def: "Any process that activates or increases the rate or extent of glial cell proliferation." [GOC:dph, GOC:sl, GOC:tb] is_a: GO:0008284 ! positive regulation of cell population proliferation is_a: GO:0014015 ! positive regulation of gliogenesis is_a: GO:0060251 ! regulation of glial cell proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0014009 ! positively regulates glial cell proliferation relationship: RO:0002213 GO:0014009 ! positively regulates glial cell proliferation [Term] id: GO:0060253 name: negative regulation of glial cell proliferation namespace: biological_process def: "Any process that stops or decreases the rate or extent of glial cell proliferation." [GOC:dph, GOC:sl, GOC:tb] is_a: GO:0008285 ! negative regulation of cell population proliferation is_a: GO:0014014 ! negative regulation of gliogenesis is_a: GO:0060251 ! regulation of glial cell proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0014009 ! negatively regulates glial cell proliferation relationship: RO:0002212 GO:0014009 ! negatively regulates glial cell proliferation [Term] id: GO:0060255 name: regulation of macromolecule metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:dph, GOC:tb] is_a: GO:0019222 ! regulation of metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0043170 ! regulates macromolecule metabolic process relationship: RO:0002211 GO:0043170 ! regulates macromolecule metabolic process [Term] id: GO:0060263 name: regulation of respiratory burst namespace: biological_process def: "Any process that modulates the rate frequency or extent of a phase of elevated metabolic activity, during which oxygen consumption increases; this leads to the production, by an NADH dependent system, of hydrogen peroxide (H2O2), superoxide anions and hydroxyl radicals." [GOC:dph, GOC:tb] is_a: GO:0019222 ! regulation of metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0045730 ! regulates respiratory burst relationship: RO:0002211 GO:0045730 ! regulates respiratory burst [Term] id: GO:0060264 name: regulation of respiratory burst involved in inflammatory response namespace: biological_process def: "Any process that modulates the rate, frequency or extent of a phase of elevated metabolic activity, during which oxygen consumption increases made as a defense response ; this leads to the production, by an NADH dependent system, of hydrogen peroxide (H2O2), superoxide anions and hydroxyl radicals." [GOC:BHF, GOC:dph, GOC:rl, GOC:tb] synonym: "regulation of respiratory burst involved in acute inflammatory response" BROAD [] is_a: GO:0002697 ! regulation of immune effector process is_a: GO:0045088 ! regulation of innate immune response is_a: GO:0050727 ! regulation of inflammatory response is_a: GO:0051239 ! regulation of multicellular organismal process is_a: GO:0060263 ! regulation of respiratory burst intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0002536 ! regulates respiratory burst involved in inflammatory response relationship: RO:0002211 GO:0002536 ! regulates respiratory burst involved in inflammatory response [Term] id: GO:0060265 name: positive regulation of respiratory burst involved in inflammatory response namespace: biological_process def: "Any process that increases the rate, frequency or extent of a phase of elevated metabolic activity, during which oxygen consumption increases made as a defense response ; this leads to the production, by an NADH dependent system, of hydrogen peroxide (H2O2), superoxide anions and hydroxyl radicals." [GOC:BHF, GOC:dph, GOC:tb] synonym: "positive regulation of respiratory burst involved in acute inflammatory response" BROAD [] is_a: GO:0002699 ! positive regulation of immune effector process is_a: GO:0045089 ! positive regulation of innate immune response is_a: GO:0050729 ! positive regulation of inflammatory response is_a: GO:0051240 ! positive regulation of multicellular organismal process is_a: GO:0060264 ! regulation of respiratory burst involved in inflammatory response is_a: GO:0060267 ! positive regulation of respiratory burst intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0002536 ! positively regulates respiratory burst involved in inflammatory response relationship: RO:0002213 GO:0002536 ! positively regulates respiratory burst involved in inflammatory response [Term] id: GO:0060266 name: negative regulation of respiratory burst involved in inflammatory response namespace: biological_process def: "Any process that decreases the rate, frequency or extent of a phase of elevated metabolic activity, during which oxygen consumption increases made as a defense response ; this leads to the production, by an NADH dependent system, of hydrogen peroxide (H2O2), superoxide anions and hydroxyl radicals." [GOC:BHF, GOC:dph, GOC:tb] synonym: "negative regulation of respiratory burst involved in acute inflammatory response" BROAD [] is_a: GO:0002698 ! negative regulation of immune effector process is_a: GO:0045824 ! negative regulation of innate immune response is_a: GO:0050728 ! negative regulation of inflammatory response is_a: GO:0051241 ! negative regulation of multicellular organismal process is_a: GO:0060264 ! regulation of respiratory burst involved in inflammatory response is_a: GO:0060268 ! negative regulation of respiratory burst is_a: GO:0060284 ! regulation of cell development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0002536 ! negatively regulates respiratory burst involved in inflammatory response relationship: RO:0002212 GO:0002536 ! negatively regulates respiratory burst involved in inflammatory response [Term] id: GO:0060267 name: positive regulation of respiratory burst namespace: biological_process def: "Any process that increases the rate frequency or extent of a phase of elevated metabolic activity, during which oxygen consumption increases; this leads to the production, by an NADH dependent system, of hydrogen peroxide (H2O2), superoxide anions and hydroxyl radicals." [GOC:dph, GOC:tb] is_a: GO:0009893 ! positive regulation of metabolic process is_a: GO:0060263 ! regulation of respiratory burst intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0045730 ! positively regulates respiratory burst relationship: RO:0002213 GO:0045730 ! positively regulates respiratory burst [Term] id: GO:0060268 name: negative regulation of respiratory burst namespace: biological_process def: "Any process that decreases the rate frequency or extent of a phase of elevated metabolic activity, during which oxygen consumption increases; this leads to the production, by an NADH dependent system, of hydrogen peroxide (H2O2), superoxide anions and hydroxyl radicals." [GOC:dph, GOC:tb] is_a: GO:0009892 ! negative regulation of metabolic process is_a: GO:0060263 ! regulation of respiratory burst intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0045730 ! negatively regulates respiratory burst relationship: RO:0002212 GO:0045730 ! negatively regulates respiratory burst [Term] id: GO:0060269 name: centripetally migrating follicle cell migration namespace: biological_process def: "The cell migration process in which a follicle cell migrates as part of an epithelial sheet between the nurse cells and the oocyte. At the end of migration, they cover the anterior of the oocyte." [GOC:dph] is_a: GO:0007297 ! follicle cell of egg chamber migration intersection_of: GO:0016477 ! cell migration intersection_of: RO:0002565 CL:0000671 ! results in movement of centripetally migrating follicle cell relationship: RO:0002565 CL:0000671 ! results in movement of centripetally migrating follicle cell [Term] id: GO:0060271 name: cilium assembly namespace: biological_process def: "The assembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole." [GOC:BHF, GOC:cilia, GOC:dph, GOC:kmv, GOC:pr, GOC:vw, ISBN:0198506732, PMID:13978319, PMID:27350441] comment: Note that we deem cilium and microtubule-based flagellum to be equivalent. synonym: "ciliogenesis" EXACT [] synonym: "cilium biogenesis" RELATED [GOC:mah] synonym: "cilium formation" EXACT [] synonym: "cilium morphogenesis" RELATED [] synonym: "cilium organization" RELATED [GOC:dph] synonym: "microtubule-based flagellum assembly" EXACT [] xref: Reactome:R-HSA-5617833 "Cilium Assembly" is_a: GO:0044782 ! cilium organization is_a: GO:0070925 ! organelle assembly is_a: GO:0120031 ! plasma membrane bounded cell projection assembly intersection_of: GO:0022607 ! cellular component assembly intersection_of: RO:0002588 GO:0005929 ! results in assembly of cilium relationship: BFO:0000051 GO:0035082 ! has part axoneme assembly relationship: BFO:0000051 GO:0035735 ! has part intraciliary transport involved in cilium assembly relationship: BFO:0000051 GO:0061512 ! has part protein localization to cilium relationship: BFO:0000051 GO:0097712 ! has part vesicle targeting, trans-Golgi to periciliary membrane compartment relationship: BFO:0000051 GO:1905349 ! has part ciliary transition zone assembly relationship: RO:0002224 GO:0097711 ! starts with ciliary basal body-plasma membrane docking relationship: RO:0002588 GO:0005929 ! results in assembly of cilium property_value: RO:0002161 NCBITaxon:3176 property_value: RO:0002161 NCBITaxon:3378 property_value: RO:0002161 NCBITaxon:3398 property_value: RO:0002161 NCBITaxon:4890 property_value: RO:0002161 NCBITaxon:5782 [Term] id: GO:0060281 name: regulation of oocyte development namespace: biological_process def: "Any process that modulates the rate or extent of the process whose specific outcome is the progression of an oocyte over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell." [GOC:dph, GOC:tb, PMID:2394318] is_a: GO:1905879 ! regulation of oogenesis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0048599 ! regulates oocyte development relationship: RO:0002211 GO:0048599 ! regulates oocyte development [Term] id: GO:0060282 name: positive regulation of oocyte development namespace: biological_process def: "Any process that increases the rate or extent of the process whose specific outcome is the progression of an oocyte over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell." [GOC:dph, GOC:tb] is_a: GO:0010720 ! positive regulation of cell development is_a: GO:0060281 ! regulation of oocyte development is_a: GO:2000243 ! positive regulation of reproductive process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0048599 ! positively regulates oocyte development relationship: RO:0002213 GO:0048599 ! positively regulates oocyte development [Term] id: GO:0060283 name: negative regulation of oocyte development namespace: biological_process def: "Any process that decreases the rate or extent of the process whose specific outcome is the progression of an oocyte over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell." [GOC:dph, GOC:tb] is_a: GO:0010721 ! negative regulation of cell development is_a: GO:0060281 ! regulation of oocyte development is_a: GO:2000242 ! negative regulation of reproductive process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0048599 ! negatively regulates oocyte development relationship: RO:0002212 GO:0048599 ! negatively regulates oocyte development [Term] id: GO:0060284 name: regulation of cell development namespace: biological_process def: "Any process that modulates the rate, frequency or extent of the progression of the cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate." [GOC:dph, GOC:tb] is_a: GO:0045595 ! regulation of cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0048468 ! regulates cell development relationship: RO:0002211 GO:0048468 ! regulates cell development [Term] id: GO:0060285 name: cilium-dependent cell motility namespace: biological_process def: "Cell motility due to the motion of one or more eukaryotic cilia. A eukaryotic cilium is a specialized organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole." [GOC:cilia, GOC:dgh, GOC:dph, GOC:krc, GOC:mlg, GOC:mtg_cambridge_2013] comment: Note that we deem eukaryotic cilia and microtubule-based flagella to be equivalent. synonym: "ciliary cell motility" RELATED [] synonym: "cilium cell motility" EXACT [] synonym: "microtubule-based flagellar cell motility" EXACT [] is_a: BFO:0000003 is_a: GO:0001539 ! cilium or flagellum-dependent cell motility relationship: BFO:0000051 GO:0003341 ! has part cilium movement property_value: RO:0002161 NCBITaxon:3176 property_value: RO:0002161 NCBITaxon:3378 property_value: RO:0002161 NCBITaxon:3398 property_value: RO:0002161 NCBITaxon:4890 property_value: RO:0002161 NCBITaxon:5782 [Term] id: GO:0060294 name: cilium movement involved in cell motility namespace: biological_process def: "Movement of cilia mediated by motor proteins that contributes to the movement of a cell." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0003341 ! cilium movement intersection_of: GO:0003341 ! cilium movement intersection_of: BFO:0000050 GO:0048870 ! part of cell motility relationship: BFO:0000050 GO:0060285 ! part of cilium-dependent cell motility property_value: RO:0002161 NCBITaxon:3176 property_value: RO:0002161 NCBITaxon:3378 property_value: RO:0002161 NCBITaxon:3398 property_value: RO:0002161 NCBITaxon:4890 property_value: RO:0002161 NCBITaxon:5782 [Term] id: GO:0060295 name: regulation of cilium movement involved in cell motility namespace: biological_process def: "Any process that modulates the rate frequency or extent of cilium movement involved in ciliary motility." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0003352 ! regulation of cilium movement is_a: GO:1902019 ! regulation of cilium-dependent cell motility intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0060294 ! regulates cilium movement involved in cell motility relationship: RO:0002211 GO:0060294 ! regulates cilium movement involved in cell motility property_value: RO:0002161 NCBITaxon:3176 property_value: RO:0002161 NCBITaxon:3378 property_value: RO:0002161 NCBITaxon:3398 property_value: RO:0002161 NCBITaxon:451864 property_value: RO:0002161 NCBITaxon:5782 [Term] id: GO:0060297 name: regulation of sarcomere organization namespace: biological_process def: "Any process that modulates the rate, frequency or extent of myofibril assembly by organization of muscle actomyosin into sarcomeres. The sarcomere is the repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs." [GOC:BHF, GOC:dph, GOC:tb] synonym: "regulation of sarcomere organisation" EXACT [GOC:mah] is_a: GO:0110020 ! regulation of actomyosin structure organization is_a: GO:1902903 ! regulation of supramolecular fiber organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0045214 ! regulates sarcomere organization relationship: RO:0002211 GO:0045214 ! regulates sarcomere organization [Term] id: GO:0060298 name: positive regulation of sarcomere organization namespace: biological_process def: "Any process that increases the rate, frequency or extent of myofibril assembly by organization of muscle actomyosin into sarcomeres. The sarcomere is the repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs." [GOC:BHF, GOC:dph, GOC:tb] synonym: "positive regulation of sarcomere organisation" EXACT [GOC:mah] is_a: GO:0051155 ! positive regulation of striated muscle cell differentiation is_a: GO:0051495 ! positive regulation of cytoskeleton organization is_a: GO:0060297 ! regulation of sarcomere organization is_a: GO:1902905 ! positive regulation of supramolecular fiber organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0045214 ! positively regulates sarcomere organization relationship: RO:0002213 GO:0045214 ! positively regulates sarcomere organization [Term] id: GO:0060299 name: negative regulation of sarcomere organization namespace: biological_process def: "Any process that decreases the rate, frequency or extent of myofibril assembly by organization of muscle actomyosin into sarcomeres. The sarcomere is the repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs." [GOC:BHF, GOC:dph, GOC:tb] synonym: "negative regulation of sarcomere organisation" EXACT [GOC:mah] is_a: GO:0010721 ! negative regulation of cell development is_a: GO:0051494 ! negative regulation of cytoskeleton organization is_a: GO:0060297 ! regulation of sarcomere organization is_a: GO:1902116 ! negative regulation of organelle assembly is_a: GO:1902904 ! negative regulation of supramolecular fiber organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0045214 ! negatively regulates sarcomere organization relationship: RO:0002212 GO:0045214 ! negatively regulates sarcomere organization [Term] id: GO:0060306 name: regulation of membrane repolarization namespace: biological_process def: "Any process that modulates the establishment or extent of a membrane potential in the polarizing direction towards the resting potential, usually from positive to negative." [GOC:BHF, GOC:dph, GOC:mtg_cardiac_conduct_nov11, GOC:tb] is_a: GO:0042391 ! regulation of membrane potential is_a: GO:0050789 ! regulation of biological process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0086009 ! regulates membrane repolarization relationship: RO:0002211 GO:0086009 ! regulates membrane repolarization [Term] id: GO:0060307 name: regulation of ventricular cardiac muscle cell membrane repolarization namespace: biological_process def: "Any process that modulates the establishment or extent of a membrane potential in the polarizing direction towards the resting potential in a ventricular cardiomyocyte." [GOC:BHF, GOC:dph, GOC:mtg_cardiac_conduct_nov11, GOC:tb] synonym: "electrocardiogram T wave" RELATED [GOC:dph, GOC:tb] synonym: "regulation of ventricular cardiac muscle cell repolarization" EXACT [GOC:dph, GOC:tb] synonym: "regulation of ventricular cardiac muscle repolarization" RELATED [GOC:dph, GOC:tb] synonym: "regulation of ventricular cardiomyocyte membrane repolarization" EXACT [] synonym: "ventricular repolarization" RELATED [GOC:dph, GOC:tb] is_a: GO:0099623 ! regulation of cardiac muscle cell membrane repolarization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0099625 ! regulates ventricular cardiac muscle cell membrane repolarization relationship: RO:0002211 GO:0099625 ! regulates ventricular cardiac muscle cell membrane repolarization [Term] id: GO:0060312 name: regulation of blood vessel remodeling namespace: biological_process def: "Any process that modulates the rate, frequency or extent of blood vessel remodeling, the reorganization or renovation of existing blood vessels." [GOC:BHF, GOC:dph, GOC:tb] synonym: "regulation of blood vessel remodelling" EXACT [] is_a: GO:0022603 ! regulation of anatomical structure morphogenesis is_a: GO:0034103 ! regulation of tissue remodeling intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0001974 ! regulates blood vessel remodeling relationship: RO:0002211 GO:0001974 ! regulates blood vessel remodeling property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0060313 name: negative regulation of blood vessel remodeling namespace: biological_process def: "Any process that decreases the rate, frequency or extent of blood vessel remodeling, the reorganization or renovation of existing blood vessels." [GOC:BHF, GOC:dph, GOC:tb] synonym: "down-regulation of blood vessel remodeling" EXACT [GOC:dph, GOC:tb] synonym: "inhibition of blood vessel remodeling" NARROW [GOC:dph, GOC:tb] synonym: "negative regulation of blood vessel remodelling" EXACT [] is_a: GO:0034104 ! negative regulation of tissue remodeling is_a: GO:0051093 ! negative regulation of developmental process is_a: GO:0060312 ! regulation of blood vessel remodeling intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0001974 ! negatively regulates blood vessel remodeling relationship: RO:0002212 GO:0001974 ! negatively regulates blood vessel remodeling property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0060319 name: primitive erythrocyte differentiation namespace: biological_process def: "Erythrocyte differentiation which occurs as part of the process of primitive hemopoiesis." [GOC:add, GOC:BHF, GOC:dph] synonym: "primitive erythropoiesis" EXACT [GOC:add, GOC:dph] synonym: "primitive RBC differentiation" EXACT [CL:0000232] synonym: "primitive red blood cell differentiation" EXACT [CL:0000232] is_a: GO:0030218 ! erythrocyte differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0002355 ! results in acquisition of features of primitive red blood cell relationship: BFO:0000050 GO:0060215 ! part of primitive hemopoiesis relationship: RO:0002315 CL:0002355 ! results in acquisition of features of primitive red blood cell [Term] id: GO:0060322 name: head development namespace: biological_process def: "The biological process whose specific outcome is the progression of a head from an initial condition to its mature state. The head is the anterior-most division of the body." [GOC:dph] is_a: GO:0048856 ! anatomical structure development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0000033 ! results in development of head relationship: RO:0002296 UBERON:0000033 ! results in development of head [Term] id: GO:0060323 name: head morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the head are generated and organized. The head is the anterior-most division of the body." [GOC:dph] is_a: BFO:0000003 is_a: GO:0009653 ! anatomical structure morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0000033 ! results in morphogenesis of head relationship: BFO:0000050 GO:0010171 ! part of body morphogenesis relationship: BFO:0000050 GO:0060322 ! part of head development relationship: RO:0002298 UBERON:0000033 ! results in morphogenesis of head [Term] id: GO:0060324 name: face development namespace: biological_process def: "The biological process whose specific outcome is the progression of a face from an initial condition to its mature state. The face is the ventral division of the head." [GOC:dph] is_a: GO:0048856 ! anatomical structure development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0001456 ! results in development of face relationship: BFO:0000050 GO:0060322 ! part of head development relationship: RO:0002296 UBERON:0001456 ! results in development of face [Term] id: GO:0060325 name: face morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the face are generated and organized. The face is the ventral division of the head." [GOC:dph] is_a: BFO:0000003 is_a: GO:0009653 ! anatomical structure morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0001456 ! results in morphogenesis of face relationship: BFO:0000050 GO:0060323 ! part of head morphogenesis relationship: BFO:0000050 GO:0060324 ! part of face development relationship: RO:0002298 UBERON:0001456 ! results in morphogenesis of face [Term] id: GO:0060326 name: cell chemotaxis namespace: biological_process def: "The directed movement of a motile cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis)." [GOC:dph] xref: Reactome:R-HSA-9664424 "Cell recruitment (pro-inflammatory response)" is_a: BFO:0000003 is_a: GO:0006935 ! chemotaxis is_a: GO:0016477 ! cell migration intersection_of: GO:0006935 ! chemotaxis intersection_of: RO:0002565 CL:0000000 ! results in movement of cell relationship: BFO:0000050 GO:0070887 ! part of cellular response to chemical stimulus relationship: RO:0002565 CL:0000000 ! results in movement of cell property_value: RO:0002161 NCBITaxon:451864 [Term] id: GO:0060327 name: cytoplasmic actin-based contraction involved in cell motility namespace: biological_process def: "The actin filament-based movement by which cytoplasmic actin filaments slide past one another resulting in a contraction that propels the cell from one place to another." [GOC:dph] is_a: GO:0070252 ! actin-mediated cell contraction intersection_of: GO:0070252 ! actin-mediated cell contraction intersection_of: BFO:0000050 GO:0048870 ! part of cell motility relationship: BFO:0000050 GO:0048870 ! part of cell motility property_value: RO:0002161 NCBITaxon:4890 [Term] id: GO:0060341 name: regulation of cellular localization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of a process in which a cell, a substance, or a cellular entity is transported to, or maintained in a specific location within or in the membrane of a cell." [GOC:dph, GOC:tb] synonym: "regulation of cellular localisation" EXACT [GOC:mah] is_a: GO:0032879 ! regulation of localization is_a: GO:0050794 ! regulation of cellular process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0051641 ! regulates cellular localization relationship: RO:0002211 GO:0051641 ! regulates cellular localization [Term] id: GO:0060343 name: trabecula formation namespace: biological_process def: "The process of creating a trabecula in an organ. A trabecula is a small, often microscopic, tissue element in the form of a small beam, strut or rod, which generally has a mechanical function. Trabecula are usually but not necessarily, composed of dense collagenous tissue." [GOC:dph] synonym: "trabecula biogenesis" RELATED [GOC:dph] synonym: "trabeculation" EXACT [GOC:dph] is_a: BFO:0000003 is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0000440 ! results in formation of anatomical entity trabecula relationship: BFO:0000050 GO:0009887 ! part of animal organ morphogenesis relationship: BFO:0000050 GO:0061383 ! part of trabecula morphogenesis relationship: RO:0002297 UBERON:0000440 ! results in formation of anatomical entity trabecula [Term] id: GO:0060344 name: liver trabecula formation namespace: biological_process def: "The process of creating a trabecula in the liver. A trabecula is a tissue element in the form of a small beam, strut or rod." [GOC:dph] synonym: "liver trabecula biogenesis" RELATED [] synonym: "liver trabeculation" EXACT [GOC:dph] is_a: GO:0060343 ! trabecula formation intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0010183 ! results in formation of anatomical entity liver trabecula relationship: BFO:0000050 GO:0001889 ! part of liver development relationship: RO:0002297 UBERON:0010183 ! results in formation of anatomical entity liver trabecula [Term] id: GO:0060345 name: spleen trabecula formation namespace: biological_process def: "The process of creating a trabecula in the spleen. A trabecula is a tissue element in the form of a small beam, strut or rod." [GOC:dph] synonym: "spleen trabecula biogenesis" RELATED [GOC:dph] synonym: "spleen trabeculation" EXACT [GOC:dph] is_a: GO:0060343 ! trabecula formation intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0001265 ! results in formation of anatomical entity trabecula of spleen relationship: BFO:0000050 GO:0048536 ! part of spleen development relationship: RO:0002297 UBERON:0001265 ! results in formation of anatomical entity trabecula of spleen [Term] id: GO:0060347 name: heart trabecula formation namespace: biological_process def: "The process of creating a trabecula in the heart. A trabecula is a tissue element in the form of a small beam, strut or rod." [GOC:dph] synonym: "cardiac trabecula formation" EXACT [GOC:dph] synonym: "cardiac trabeculation" EXACT [GOC:dph] synonym: "heart trabecula biogenesis" RELATED [GOC:dph] synonym: "heart trabeculation" EXACT [GOC:dph] is_a: GO:0060343 ! trabecula formation intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0002511 ! results in formation of anatomical entity trabecula carnea relationship: BFO:0000050 GO:0003206 ! part of cardiac chamber morphogenesis relationship: BFO:0000050 GO:0061384 ! part of heart trabecula morphogenesis relationship: RO:0002297 UBERON:0002511 ! results in formation of anatomical entity trabecula carnea [Term] id: GO:0060348 name: bone development namespace: biological_process def: "The process whose specific outcome is the progression of bone over time, from its formation to the mature structure. Bone is the hard skeletal connective tissue consisting of both mineral and cellular components." [GOC:dph] is_a: GO:0048513 ! animal organ development intersection_of: GO:0048513 ! animal organ development intersection_of: RO:0002296 UBERON:0001474 ! results in development of bone element relationship: BFO:0000050 GO:0001501 ! part of skeletal system development relationship: RO:0002162 NCBITaxon:7742 ! in taxon Vertebrata relationship: RO:0002296 UBERON:0001474 ! results in development of bone element [Term] id: GO:0060349 name: bone morphogenesis namespace: biological_process def: "The process in which bones are generated and organized." [GOC:dph] is_a: GO:0009887 ! animal organ morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0001474 ! results in morphogenesis of bone element relationship: BFO:0000050 GO:0048705 ! part of skeletal system morphogenesis relationship: BFO:0000050 GO:0060348 ! part of bone development relationship: RO:0002298 UBERON:0001474 ! results in morphogenesis of bone element [Term] id: GO:0060350 name: endochondral bone morphogenesis namespace: biological_process def: "The process in which bones are generated and organized as a result of the conversion of initial cartilaginous anlage into bone." [GOC:dph, PMID:11680679] is_a: GO:0060349 ! bone morphogenesis intersection_of: GO:0060349 ! bone morphogenesis intersection_of: RO:0002298 UBERON:0002513 ! results in morphogenesis of endochondral bone relationship: RO:0002298 UBERON:0002513 ! results in morphogenesis of endochondral bone [Term] id: GO:0060351 name: cartilage development involved in endochondral bone morphogenesis namespace: biological_process def: "The process whose specific outcome is the progression of the cartilage that will provide a scaffold for mineralization of endochondral bones." [GOC:dph] is_a: GO:0051216 ! cartilage development intersection_of: GO:0051216 ! cartilage development intersection_of: BFO:0000050 GO:0060350 ! part of endochondral bone morphogenesis relationship: BFO:0000050 GO:0060350 ! part of endochondral bone morphogenesis [Term] id: GO:0060359 name: response to ammonium ion namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ammonium stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:23509267] synonym: "response to ammonia" EXACT [] is_a: GO:1901698 ! response to nitrogen compound intersection_of: GO:0050896 ! response to stimulus intersection_of: RO:0004009 CHEBI:28938 ! has primary input relationship: RO:0004009 CHEBI:28938 ! has primary input [Term] id: GO:0060363 name: cranial suture morphogenesis namespace: biological_process def: "The process in which any suture between cranial bones is generated and organized." [GOC:dph, GOC:pr, GOC:sl] is_a: GO:0097094 ! craniofacial suture morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0003685 ! results in morphogenesis of cranial suture relationship: RO:0002298 UBERON:0003685 ! results in morphogenesis of cranial suture [Term] id: GO:0060364 name: frontal suture morphogenesis namespace: biological_process def: "The process in which the frontal suture is generated and organized." [GOC:dph, GOC:sl] synonym: "interfrontal suture morphogenesis" EXACT [] is_a: GO:0060363 ! cranial suture morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0002490 ! results in morphogenesis of frontal suture relationship: RO:0002298 UBERON:0002490 ! results in morphogenesis of frontal suture [Term] id: GO:0060372 name: regulation of atrial cardiac muscle cell membrane repolarization namespace: biological_process def: "Any process that modulates the establishment or extent of a membrane potential in the polarizing direction towards the resting potential in an atrial cardiomyocyte." [GOC:dph, GOC:tb] synonym: "atrial repolarization" RELATED [GOC:dph, GOC:tb] synonym: "electrocardiogram QRS complex" RELATED [GOC:dph, GOC:tb] synonym: "regulation of atrial cardiac muscle cell repolarization" EXACT [GOC:dph, GOC:tb] synonym: "regulation of atrial cardiomyocyte membrane repolarization" EXACT [] is_a: GO:0099623 ! regulation of cardiac muscle cell membrane repolarization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0099624 ! regulates atrial cardiac muscle cell membrane repolarization relationship: RO:0002211 GO:0099624 ! regulates atrial cardiac muscle cell membrane repolarization [Term] id: GO:0060374 name: mast cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized myeloid precursor cell acquires the specialized features of a mast cell. A mast cell is a cell that is found in almost all tissues containing numerous basophilic granules and capable of releasing large amounts of histamine and heparin upon activation." [GOC:dph, GOC:tb] is_a: GO:0002573 ! myeloid leukocyte differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000097 ! results in acquisition of features of mast cell relationship: RO:0002315 CL:0000097 ! results in acquisition of features of mast cell [Term] id: GO:0060375 name: regulation of mast cell differentiation namespace: biological_process def: "Any process that modulates the rate, frequency or extent of mast cell differentiation, the process in which a relatively unspecialized myeloid precursor cell acquires the specialized features of a mast cell. A mast cell is a cell that is found in almost all tissues containing numerous basophilic granules and capable of releasing large amounts of histamine and heparin upon activation." [GOC:dph, GOC:tb] is_a: GO:0002761 ! regulation of myeloid leukocyte differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0060374 ! regulates mast cell differentiation relationship: RO:0002211 GO:0060374 ! regulates mast cell differentiation [Term] id: GO:0060376 name: positive regulation of mast cell differentiation namespace: biological_process def: "Any process that increases the rate, frequency or extent of mast cell differentiation, the process in which a relatively unspecialized myeloid precursor cell acquires the specialized features of a mast cell. A mast cell is a cell that is found in almost all tissues containing numerous basophilic granules and capable of releasing large amounts of histamine and heparin upon activation." [GOC:dph, GOC:tb] is_a: GO:0002763 ! positive regulation of myeloid leukocyte differentiation is_a: GO:0060375 ! regulation of mast cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0060374 ! positively regulates mast cell differentiation relationship: RO:0002213 GO:0060374 ! positively regulates mast cell differentiation [Term] id: GO:0060377 name: negative regulation of mast cell differentiation namespace: biological_process def: "Any process that decreases the rate, frequency or extent of mast cell differentiation, the process in which a relatively unspecialized myeloid precursor cell acquires the specialized features of a mast cell. A mast cell is a cell that is found in almost all tissues containing numerous basophilic granules and capable of releasing large amounts of histamine and heparin upon activation." [GOC:dph, GOC:tb] is_a: GO:0002762 ! negative regulation of myeloid leukocyte differentiation is_a: GO:0060375 ! regulation of mast cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0060374 ! negatively regulates mast cell differentiation relationship: RO:0002212 GO:0060374 ! negatively regulates mast cell differentiation [Term] id: GO:0060379 name: cardiac muscle cell myoblast differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a cardiac myoblast. A cardiac myoblast is a precursor cell that has been committed to a cardiac muscle cell fate but retains the ability to divide and proliferate throughout life." [GOC:dph, GOC:tb] synonym: "cardiac myoblast differentiation" RELATED [GOC:dph, GOC:tb] synonym: "myocardial precursor cell differentiation" EXACT [GOC:mtg_heart] is_a: GO:0010002 ! cardioblast differentiation is_a: GO:0045445 ! myoblast differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000513 ! results in acquisition of features of cardiac muscle myoblast relationship: RO:0002315 CL:0000513 ! results in acquisition of features of cardiac muscle myoblast [Term] id: GO:0060404 name: axonemal microtubule depolymerization namespace: biological_process def: "The removal of tubulin heterodimers from one or both ends of an axonemal microtubule. An axonemal microtubule is a microtubule in the axoneme of a cilium or flagellum; an axoneme contains nine modified doublet microtubules surrounding a pair of single microtubules." [GOC:cilia, GOC:dph, GOC:krc, GOC:tb] is_a: GO:0010938 ! cytoplasmic microtubule depolymerization is_a: GO:0061523 ! cilium disassembly intersection_of: GO:0007019 ! microtubule depolymerization intersection_of: BFO:0000066 GO:0005930 ! occurs in axoneme relationship: BFO:0000066 GO:0005930 ! occurs in axoneme [Term] id: GO:0060408 name: regulation of acetylcholine metabolic process namespace: biological_process def: "Any process that modulates the rate, frequency or extent of the chemical reactions and pathways involving acetylcholine, the acetic acid ester of the organic base choline. Acetylcholine is a major neurotransmitter and neuromodulator both in the central and peripheral nervous systems. It also acts as a paracrine signal in various non-neural tissues." [GOC:dph, GOC:tb] is_a: GO:0033238 ! regulation of amine metabolic process is_a: GO:0080090 ! regulation of primary metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0008291 ! regulates acetylcholine metabolic process relationship: RO:0002211 GO:0008291 ! regulates acetylcholine metabolic process [Term] id: GO:0060409 name: positive regulation of acetylcholine metabolic process namespace: biological_process def: "Any process that increases the rate, frequency or extent of the chemical reactions and pathways involving acetylcholine, the acetic acid ester of the organic base choline. Acetylcholine is a major neurotransmitter and neuromodulator both in the central and peripheral nervous systems. It also acts as a paracrine signal in various non-neural tissues." [GOC:dph, GOC:tb] is_a: GO:0033240 ! positive regulation of amine metabolic process is_a: GO:0060408 ! regulation of acetylcholine metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0008291 ! positively regulates acetylcholine metabolic process relationship: RO:0002213 GO:0008291 ! positively regulates acetylcholine metabolic process [Term] id: GO:0060411 name: cardiac septum morphogenesis namespace: biological_process def: "The process in which the anatomical structure of a cardiac septum is generated and organized. A cardiac septum is a partition that separates parts of the heart." [GOC:dph, GOC:mtg_heart] synonym: "heart septum morphogenesis" EXACT [] is_a: BFO:0000003 is_a: GO:0009653 ! anatomical structure morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0002099 ! results in morphogenesis of cardiac septum relationship: BFO:0000050 GO:0003206 ! part of cardiac chamber morphogenesis relationship: BFO:0000050 GO:0003279 ! part of cardiac septum development relationship: RO:0002298 UBERON:0002099 ! results in morphogenesis of cardiac septum [Term] id: GO:0060412 name: ventricular septum morphogenesis namespace: biological_process def: "The developmental process in which a ventricular septum is generated and organized. A ventricular septum is an anatomical structure that separates the lower chambers (ventricles) of the heart from one another." [GOC:dph] synonym: "interventricular septum morphogenesis" EXACT [GOC:dph] is_a: GO:0060411 ! cardiac septum morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0002094 ! results in morphogenesis of interventricular septum relationship: BFO:0000050 GO:0003281 ! part of ventricular septum development relationship: RO:0002298 UBERON:0002094 ! results in morphogenesis of interventricular septum [Term] id: GO:0060413 name: atrial septum morphogenesis namespace: biological_process def: "The developmental process in which atrial septum is generated and organized. The atrial septum separates the upper chambers (the atria) of the heart from one another." [GOC:dph, GOC:mtg_heart] synonym: "interatrial septum morphogenesis" EXACT [GOC:dph] is_a: GO:0060411 ! cardiac septum morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0002085 ! results in morphogenesis of interatrial septum relationship: BFO:0000050 GO:0003209 ! part of cardiac atrium morphogenesis relationship: BFO:0000050 GO:0003283 ! part of atrial septum development relationship: RO:0002298 UBERON:0002085 ! results in morphogenesis of interatrial septum [Term] id: GO:0060414 name: aorta smooth muscle tissue morphogenesis namespace: biological_process def: "The process in which the structure of the smooth muscle tissue surrounding the aorta is generated and organized. An aorta is an artery that carries blood from the heart to other parts of the body." [GOC:bf, GOC:dgh, GOC:dph, Wikipedia:Aorta] is_a: GO:0060415 ! muscle tissue morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0004178 ! results in morphogenesis of aorta smooth muscle tissue relationship: BFO:0000050 GO:0035909 ! part of aorta morphogenesis relationship: BFO:0000050 GO:0048745 ! part of smooth muscle tissue development relationship: RO:0002298 UBERON:0004178 ! results in morphogenesis of aorta smooth muscle tissue [Term] id: GO:0060415 name: muscle tissue morphogenesis namespace: biological_process def: "The process in which the anatomical structures of muscle tissue are generated and organized. Muscle tissue consists of a set of cells that are part of an organ and carry out a contractive function." [GOC:dph] is_a: GO:0048729 ! tissue morphogenesis intersection_of: GO:0048729 ! tissue morphogenesis intersection_of: RO:0002298 UBERON:0002385 ! results in morphogenesis of muscle tissue relationship: BFO:0000050 GO:0048644 ! part of muscle organ morphogenesis relationship: RO:0002298 UBERON:0002385 ! results in morphogenesis of muscle tissue [Term] id: GO:0060419 name: heart growth namespace: biological_process def: "The increase in size or mass of the heart." [GOC:dph, GOC:tb] is_a: GO:0035265 ! organ growth intersection_of: GO:0048589 ! developmental growth intersection_of: RO:0002343 UBERON:0000948 ! results in growth of heart relationship: BFO:0000050 GO:0007507 ! part of heart development relationship: RO:0002343 UBERON:0000948 ! results in growth of heart [Term] id: GO:0060420 name: regulation of heart growth namespace: biological_process def: "Any process that modulates the rate or extent of heart growth. Heart growth is the increase in size or mass of the heart." [GOC:dph, GOC:tb] is_a: GO:0046620 ! regulation of organ growth is_a: GO:2000026 ! regulation of multicellular organismal development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0060419 ! regulates heart growth relationship: RO:0002211 GO:0060419 ! regulates heart growth [Term] id: GO:0060421 name: positive regulation of heart growth namespace: biological_process def: "Any process that increases the rate or extent of heart growth. Heart growth is the increase in size or mass of the heart." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0046622 ! positive regulation of organ growth is_a: GO:0060420 ! regulation of heart growth intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0060419 ! positively regulates heart growth relationship: RO:0002213 GO:0060419 ! positively regulates heart growth [Term] id: GO:0060425 name: lung morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the lung are generated and organized." [GOC:dph] is_a: GO:0009887 ! animal organ morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0002048 ! results in morphogenesis of lung relationship: BFO:0000050 GO:0030324 ! part of lung development relationship: RO:0002298 UBERON:0002048 ! results in morphogenesis of lung [Term] id: GO:0060426 name: lung vasculature development namespace: biological_process def: "The biological process whose specific outcome is the progression of a lung vasculature from an initial condition to its mature state. This process begins with the formation of the lung vasculature and ends with the mature structure. The lung vasculature is composed of the tubule structures that carry blood or lymph in the lungs." [GOC:dph, GOC:mtg_lung] synonym: "pulmonary vasculature development" EXACT [GOC:dph, GOC:mtg_lung] is_a: GO:0001944 ! vasculature development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0000102 ! results in development of lung vasculature relationship: BFO:0000050 GO:0030324 ! part of lung development relationship: RO:0002296 UBERON:0000102 ! results in development of lung vasculature [Term] id: GO:0060427 name: lung connective tissue development namespace: biological_process def: "The biological process whose specific outcome is the progression of lung connective tissue from an initial condition to its mature state. This process begins with the formation of lung connective tissue and ends with the mature structure. The lung connective tissue is a material made up of fibers forming a framework and support structure for the lungs." [GOC:dph, GOC:mtg_lung] synonym: "pulmonary connective tissue development" EXACT [] is_a: GO:0061448 ! connective tissue development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0000114 ! results in development of lung connective tissue relationship: BFO:0000050 GO:0030324 ! part of lung development relationship: RO:0002296 UBERON:0000114 ! results in development of lung connective tissue [Term] id: GO:0060428 name: lung epithelium development namespace: biological_process def: "The biological process whose specific outcome is the progression of the lung epithelium from an initial condition to its mature state. This process begins with the formation of lung epithelium and ends with the mature structure. The lung epithelium is the specialized epithelium that lines the inside of the lung." [GOC:dph, GOC:mtg_lung] synonym: "pulmonary epithelium development" EXACT [GOC:dph, GOC:mtg_lung] is_a: GO:0060429 ! epithelium development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0000115 ! results in development of lung epithelium relationship: BFO:0000050 GO:0030324 ! part of lung development relationship: RO:0002296 UBERON:0000115 ! results in development of lung epithelium [Term] id: GO:0060429 name: epithelium development namespace: biological_process def: "The process whose specific outcome is the progression of an epithelium over time, from its formation to the mature structure. An epithelium is a tissue that covers the internal or external surfaces of an anatomical structure." [GOC:dph, GOC:mtg_lung] subset: goslim_drosophila is_a: GO:0009888 ! tissue development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0000483 ! results in development of epithelium relationship: RO:0002296 UBERON:0000483 ! results in development of epithelium [Term] id: GO:0060431 name: primary lung bud formation namespace: biological_process def: "The morphogenetic process in which the foregut region specified to become the lung forms the initial left and right buds." [GOC:dph, GOC:mtg_lung] synonym: "lung formation" EXACT [GOC:dph] is_a: GO:0016331 ! morphogenesis of embryonic epithelium is_a: GO:0048645 ! animal organ formation is_a: GO:0060441 ! epithelial tube branching involved in lung morphogenesis is_a: GO:0060572 ! morphogenesis of an epithelial bud intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0002048 ! results in formation of anatomical entity lung relationship: RO:0002297 UBERON:0002048 ! results in formation of anatomical entity lung [Term] id: GO:0060433 name: bronchus development namespace: biological_process def: "The biological process whose specific outcome is the progression of a bronchus from an initial condition to its mature state. This process begins with the formation of the bronchus and ends with the mature structure. The bronchus is the portion of the airway that connects to the lungs." [GOC:dph] is_a: GO:0030323 ! respiratory tube development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0002185 ! results in development of bronchus relationship: BFO:0000050 GO:0060541 ! part of respiratory system development relationship: RO:0002296 UBERON:0002185 ! results in development of bronchus [Term] id: GO:0060434 name: bronchus morphogenesis namespace: biological_process def: "The process in which the bronchus is generated and organized. The bronchus is the portion of the airway that connects to the lungs." [GOC:dph] is_a: GO:0009887 ! animal organ morphogenesis is_a: GO:0035239 ! tube morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0002185 ! results in morphogenesis of bronchus relationship: BFO:0000050 GO:0060433 ! part of bronchus development relationship: RO:0002298 UBERON:0002185 ! results in morphogenesis of bronchus [Term] id: GO:0060435 name: bronchiole development namespace: biological_process def: "The biological process whose specific outcome is the progression of a bronchiole from an initial condition to its mature state. This process begins with the formation of the bronchiole and ends with the mature structure. A bronchiole is the first airway branch that no longer contains cartilage; it is a branch of the bronchi." [GOC:dph, GOC:mtg_lung] is_a: GO:0030323 ! respiratory tube development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0002186 ! results in development of bronchiole relationship: BFO:0000050 GO:0030324 ! part of lung development relationship: RO:0002296 UBERON:0002186 ! results in development of bronchiole [Term] id: GO:0060436 name: bronchiole morphogenesis namespace: biological_process def: "The process in which a bronchiole is generated and organized. A bronchiole is the first airway branch that no longer contains cartilage; it is a branch of the bronchi." [GOC:dph] is_a: GO:0035239 ! tube morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0002186 ! results in morphogenesis of bronchiole relationship: BFO:0000050 GO:0060435 ! part of bronchiole development relationship: RO:0002298 UBERON:0002186 ! results in morphogenesis of bronchiole [Term] id: GO:0060437 name: lung growth namespace: biological_process def: "The increase in size or mass of a lung. In all air-breathing vertebrates the lungs are developed from the ventral wall of the oesophagus as a pouch which divides into two sacs. In amphibians and many reptiles the lungs retain very nearly this primitive sac-like character, but in the higher forms the connection with the esophagus becomes elongated into the windpipe and the inner walls of the sacs become more and more divided, until, in the mammals, the air spaces become minutely divided into tubes ending in small air cells, in the walls of which the blood circulates in a fine network of capillaries. In mammals the lungs are more or less divided into lobes, and each lung occupies a separate cavity in the thorax." [GOC:dph] is_a: GO:0035265 ! organ growth intersection_of: GO:0048589 ! developmental growth intersection_of: RO:0002343 UBERON:0002048 ! results in growth of lung relationship: BFO:0000050 GO:0030324 ! part of lung development relationship: RO:0002343 UBERON:0002048 ! results in growth of lung [Term] id: GO:0060438 name: trachea development namespace: biological_process def: "The process whose specific outcome is the progression of a trachea over time, from its formation to the mature structure. The trachea is the portion of the airway that attaches to the bronchi as it branches." [GOC:dph] is_a: GO:0048513 ! animal organ development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0001005 ! results in development of respiratory airway relationship: BFO:0000050 GO:0060541 ! part of respiratory system development relationship: RO:0002296 UBERON:0001005 ! results in development of respiratory airway [Term] id: GO:0060439 name: trachea morphogenesis namespace: biological_process def: "The process in which a trachea is generated and organized. The trachea is the portion of the airway that attaches to the bronchi as it branches." [GOC:dph] is_a: GO:0009887 ! animal organ morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0001005 ! results in morphogenesis of respiratory airway relationship: BFO:0000050 GO:0060438 ! part of trachea development relationship: RO:0002298 UBERON:0001005 ! results in morphogenesis of respiratory airway [Term] id: GO:0060440 name: trachea formation namespace: biological_process def: "The process pertaining to the initial formation of a trachea from unspecified parts. The process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the trachea is recognizable. The trachea is the portion of the airway that attaches to the bronchi as it branches." [GOC:dph] is_a: GO:0048645 ! animal organ formation intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0001005 ! results in formation of anatomical entity respiratory airway relationship: BFO:0000050 GO:0060439 ! part of trachea morphogenesis relationship: RO:0002297 UBERON:0001005 ! results in formation of anatomical entity respiratory airway [Term] id: GO:0060441 name: epithelial tube branching involved in lung morphogenesis namespace: biological_process def: "The process in which a highly ordered sequence of patterning events generates the branched epithelial tubes of the lung, consisting of reiterated combinations of bud outgrowth, elongation, and dichotomous subdivision of terminal units." [GOC:dph, GOC:mtg_lung] synonym: "lung branching morphogenesis" EXACT [GOC:dph] is_a: GO:0048754 ! branching morphogenesis of an epithelial tube intersection_of: GO:0048754 ! branching morphogenesis of an epithelial tube intersection_of: BFO:0000050 GO:0060425 ! part of lung morphogenesis relationship: BFO:0000050 GO:0060425 ! part of lung morphogenesis [Term] id: GO:0060442 name: branching involved in prostate gland morphogenesis namespace: biological_process def: "The process in which the branching structure of the prostate gland is generated and organized. A branch is a division or offshoot from a main stem." [GOC:dph] synonym: "prostate branching" RELATED [GOC:dph] synonym: "prostate gland branching morphogenesis" EXACT [GOC:dph] is_a: GO:0060740 ! prostate gland epithelium morphogenesis is_a: GO:0061138 ! morphogenesis of a branching epithelium intersection_of: GO:0061138 ! morphogenesis of a branching epithelium intersection_of: BFO:0000050 GO:0060512 ! part of prostate gland morphogenesis [Term] id: GO:0060443 name: mammary gland morphogenesis namespace: biological_process def: "The process in which anatomical structures of the mammary gland are generated and organized. Morphogenesis refers to the creation of shape. The mammary gland is a large compound sebaceous gland that in female mammals is modified to secrete milk." [GOC:dph] is_a: GO:0022612 ! gland morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0001911 ! results in morphogenesis of mammary gland relationship: BFO:0000050 GO:0030879 ! part of mammary gland development relationship: RO:0002298 UBERON:0001911 ! results in morphogenesis of mammary gland [Term] id: GO:0060444 name: branching involved in mammary gland duct morphogenesis namespace: biological_process def: "The process in which the branching structure of the mammary gland duct is generated and organized. The mammary gland is a large compound sebaceous gland that in female mammals is modified to secrete milk." [GOC:dph] synonym: "mammary gland branching morphogenesis" EXACT [GOC:dph] is_a: GO:0048754 ! branching morphogenesis of an epithelial tube intersection_of: GO:0061138 ! morphogenesis of a branching epithelium intersection_of: BFO:0000050 GO:0060603 ! part of mammary gland duct morphogenesis relationship: BFO:0000050 GO:0060603 ! part of mammary gland duct morphogenesis [Term] id: GO:0060445 name: branching involved in salivary gland morphogenesis namespace: biological_process def: "The process in which the branching structure of the salivary gland is generated and organized." [GOC:dph] is_a: GO:0061138 ! morphogenesis of a branching epithelium intersection_of: GO:0061138 ! morphogenesis of a branching epithelium intersection_of: BFO:0000050 GO:0007435 ! part of salivary gland morphogenesis relationship: BFO:0000050 GO:0007435 ! part of salivary gland morphogenesis [Term] id: GO:0060446 name: branching involved in open tracheal system development namespace: biological_process def: "The process in which the anatomical structures of branches in the open tracheal system are generated and organized." [GOC:dph] is_a: GO:0048754 ! branching morphogenesis of an epithelial tube intersection_of: GO:0048754 ! branching morphogenesis of an epithelial tube intersection_of: BFO:0000050 GO:0007424 ! part of open tracheal system development relationship: BFO:0000050 GO:0007424 ! part of open tracheal system development [Term] id: GO:0060450 name: positive regulation of hindgut contraction namespace: biological_process def: "Any process that increases the frequency, rate or extent of muscle contraction of the hindgut, the posterior part of the alimentary canal, including the rectum, and the large intestine." [GOC:dph, GOC:tb] is_a: GO:0043134 ! regulation of hindgut contraction is_a: GO:0045987 ! positive regulation of smooth muscle contraction is_a: GO:0060456 ! positive regulation of digestive system process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0043133 ! positively regulates hindgut contraction relationship: RO:0002213 GO:0043133 ! positively regulates hindgut contraction property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0060451 name: negative regulation of hindgut contraction namespace: biological_process def: "Any process that decreases the frequency, rate or extent of muscle contraction of the hindgut, the posterior part of the alimentary canal, including the rectum, and the large intestine." [GOC:dph, GOC:tb] is_a: GO:0043134 ! regulation of hindgut contraction is_a: GO:0045986 ! negative regulation of smooth muscle contraction is_a: GO:0060457 ! negative regulation of digestive system process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0043133 ! negatively regulates hindgut contraction relationship: RO:0002212 GO:0043133 ! negatively regulates hindgut contraction property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0060452 name: positive regulation of cardiac muscle contraction namespace: biological_process def: "Any process that increases the frequency, rate or extent of cardiac muscle contraction." [GOC:dph, GOC:tb] is_a: GO:0045823 ! positive regulation of heart contraction is_a: GO:0045989 ! positive regulation of striated muscle contraction is_a: GO:0055117 ! regulation of cardiac muscle contraction intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0060048 ! positively regulates cardiac muscle contraction relationship: RO:0002213 GO:0060048 ! positively regulates cardiac muscle contraction property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0060453 name: regulation of gastric acid secretion namespace: biological_process def: "Any process that modulates the rate frequency or extent of gastric secretion. Gastric secretion is the regulated release of gastric acid (hydrochloric acid) by parietal or oxyntic cells during digestion." [GOC:dph, GOC:tb] is_a: GO:0044058 ! regulation of digestive system process is_a: GO:0051046 ! regulation of secretion intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0001696 ! regulates gastric acid secretion relationship: RO:0002211 GO:0001696 ! regulates gastric acid secretion property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0060454 name: positive regulation of gastric acid secretion namespace: biological_process def: "Any process that increases the rate frequency or extent of gastric secretion. Gastric secretion is the regulated release of gastric acid (hydrochloric acid) by parietal or oxyntic cells during digestion." [GOC:dph, GOC:tb] is_a: GO:0051047 ! positive regulation of secretion is_a: GO:0060453 ! regulation of gastric acid secretion is_a: GO:0060456 ! positive regulation of digestive system process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0001696 ! positively regulates gastric acid secretion relationship: RO:0002213 GO:0001696 ! positively regulates gastric acid secretion property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0060455 name: negative regulation of gastric acid secretion namespace: biological_process def: "Any process that decreases the rate frequency or extent of gastric secretion. Gastric secretion is the regulated release of gastric acid (hydrochloric acid) by parietal or oxyntic cells during digestion." [GOC:dph, GOC:tb] is_a: GO:0051048 ! negative regulation of secretion is_a: GO:0060453 ! regulation of gastric acid secretion is_a: GO:0060457 ! negative regulation of digestive system process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0001696 ! negatively regulates gastric acid secretion relationship: RO:0002212 GO:0001696 ! negatively regulates gastric acid secretion property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0060456 name: positive regulation of digestive system process namespace: biological_process def: "Any process that increases the frequency, rate or extent of a digestive system process, a physical, chemical, or biochemical process carried out by living organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism." [GOC:dph, GOC:tb] is_a: GO:0044058 ! regulation of digestive system process is_a: GO:0051240 ! positive regulation of multicellular organismal process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0022600 ! positively regulates digestive system process relationship: RO:0002213 GO:0022600 ! positively regulates digestive system process property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0060457 name: negative regulation of digestive system process namespace: biological_process def: "Any process that decreases the frequency, rate or extent of a digestive system process, a physical, chemical, or biochemical process carried out by living organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism." [GOC:dph, GOC:tb] is_a: GO:0044058 ! regulation of digestive system process is_a: GO:0051241 ! negative regulation of multicellular organismal process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0022600 ! negatively regulates digestive system process relationship: RO:0002212 GO:0022600 ! negatively regulates digestive system process property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0060458 name: right lung development namespace: biological_process def: "The biological process whose specific outcome is the progression of a right lung from an initial condition to its mature state. This process begins with the formation of the right lung and ends with the mature structure. The right lung is the lung which is on the right side of the anterior posterior axis looking from a dorsal to ventral aspect." [GOC:dph, GOC:mtg_lung] synonym: "right pulmonary development" EXACT [GOC:dph, GOC:mtg_lung] is_a: GO:0030324 ! lung development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0002167 ! results in development of right lung relationship: RO:0002296 UBERON:0002167 ! results in development of right lung [Term] id: GO:0060459 name: left lung development namespace: biological_process def: "The biological process whose specific outcome is the progression of a left lung from an initial condition to its mature state. This process begins with the formation of the left lung and ends with the mature structure. The left lung is the lung which is on the left side of the anterior posterior axis looking from a dorsal to ventral aspect." [GOC:dph, GOC:mtg_lung] synonym: "left pulmonary development" EXACT [GOC:dph] is_a: GO:0030324 ! lung development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0002168 ! results in development of left lung relationship: RO:0002296 UBERON:0002168 ! results in development of left lung [Term] id: GO:0060460 name: left lung morphogenesis namespace: biological_process def: "The process in which anatomical structures of the left lung are generated and organized." [GOC:dph] is_a: GO:0060425 ! lung morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0002168 ! results in morphogenesis of left lung relationship: BFO:0000050 GO:0060459 ! part of left lung development relationship: RO:0002298 UBERON:0002168 ! results in morphogenesis of left lung [Term] id: GO:0060461 name: right lung morphogenesis namespace: biological_process def: "The process in which anatomical structures of the right lung are generated and organized." [GOC:dph, GOC:mtg_lung] is_a: GO:0060425 ! lung morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0002167 ! results in morphogenesis of right lung relationship: BFO:0000050 GO:0060458 ! part of right lung development relationship: RO:0002298 UBERON:0002167 ! results in morphogenesis of right lung [Term] id: GO:0060462 name: lung lobe development namespace: biological_process def: "The biological process whose specific outcome is the progression of a lung lobe from an initial condition to its mature state. This process begins with the formation of a lung lobe by branching morphogenesis and ends with the mature structure. A lung lobe is one of the rounded projections that compose the lung." [GOC:dph] is_a: GO:0048856 ! anatomical structure development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0000101 ! results in development of lobe of lung relationship: BFO:0000050 GO:0030324 ! part of lung development relationship: RO:0002296 UBERON:0000101 ! results in development of lobe of lung [Term] id: GO:0060463 name: lung lobe morphogenesis namespace: biological_process def: "The process in which the anatomical structures of a lung lobe are generated and organized. A lung lobe is a projection that extends from the lung." [GOC:dph] is_a: BFO:0000003 is_a: GO:0009653 ! anatomical structure morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0000101 ! results in morphogenesis of lobe of lung relationship: BFO:0000050 GO:0060425 ! part of lung morphogenesis relationship: BFO:0000050 GO:0060462 ! part of lung lobe development relationship: RO:0002298 UBERON:0000101 ! results in morphogenesis of lobe of lung [Term] id: GO:0060464 name: lung lobe formation namespace: biological_process def: "The developmental process pertaining to the initial formation of a lung lobe from unspecified parts. This process begins with the specific processes that contribute to the appearance of the lobe and ends when the structural rudiment is recognizable. A lung lobe is a projection that extends from the lung." [GOC:dph] is_a: BFO:0000003 is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0000101 ! results in formation of anatomical entity lobe of lung relationship: BFO:0000050 GO:0060463 ! part of lung lobe morphogenesis relationship: RO:0002297 UBERON:0000101 ! results in formation of anatomical entity lobe of lung [Term] id: GO:0060465 name: pharynx development namespace: biological_process def: "The biological process whose specific outcome is the progression of a pharynx from an initial condition to its mature state. The pharynx is the part of the digestive system immediately posterior to the mouth." [GOC:dph, GOC:rk] synonym: "pharyngeal development" RELATED [] is_a: GO:0048856 ! anatomical structure development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0006562 ! results in development of pharynx relationship: BFO:0000050 GO:0048565 ! part of digestive tract development relationship: RO:0002296 UBERON:0006562 ! results in development of pharynx [Term] id: GO:0060467 name: negative regulation of fertilization namespace: biological_process def: "Any process that decreases the rate, frequency or extent of fertilization. Fertilization is the union of gametes of opposite sexes during the process of sexual reproduction to form a zygote. It involves the fusion of the gametic nuclei (karyogamy) and cytoplasm (plasmogamy)." [GOC:dph] is_a: GO:0080154 ! regulation of fertilization is_a: GO:2000242 ! negative regulation of reproductive process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0009566 ! negatively regulates fertilization relationship: RO:0002212 GO:0009566 ! negatively regulates fertilization [Term] id: GO:0060468 name: prevention of polyspermy namespace: biological_process def: "The negative regulation of fertilization process that takes place as part of egg activation, ensuring that only a single sperm fertilizes the egg." [GOC:dph] synonym: "negative regulation of fertilization involved in egg activation" EXACT [GOC:dph] synonym: "polyspermy block" EXACT [GOC:dph] is_a: GO:0060467 ! negative regulation of fertilization intersection_of: GO:0060467 ! negative regulation of fertilization intersection_of: BFO:0000050 GO:0007343 ! part of egg activation relationship: BFO:0000050 GO:0007343 ! part of egg activation [Term] id: GO:0060470 name: positive regulation of cytosolic calcium ion concentration involved in egg activation namespace: biological_process def: "The process that increases the concentration of calcium ions in the cytosol after fertilization or the physiological activation of an egg." [GOC:dph] synonym: "elevation of cytosolic calcium ion concentration involved in egg activation" EXACT [] is_a: GO:0007204 ! positive regulation of cytosolic calcium ion concentration intersection_of: GO:0007204 ! positive regulation of cytosolic calcium ion concentration intersection_of: BFO:0000050 GO:0007343 ! part of egg activation relationship: BFO:0000050 GO:0007343 ! part of egg activation [Term] id: GO:0060474 name: positive regulation of flagellated sperm motility involved in capacitation namespace: biological_process def: "The process in which the controlled movement of a flagellated sperm cell is initiated as part of the process required for flagellated sperm to reach fertilization competence." [GOC:cilia, GOC:dph, GOC:krc] synonym: "positive regulation of sperm motility involved in capacitation" RELATED [] is_a: GO:0022414 ! reproductive process is_a: GO:1902093 ! positive regulation of flagellated sperm motility intersection_of: GO:1902093 ! positive regulation of flagellated sperm motility intersection_of: BFO:0000050 GO:0048240 ! part of sperm capacitation relationship: BFO:0000050 GO:0048240 ! part of sperm capacitation property_value: RO:0002161 NCBITaxon:3176 property_value: RO:0002161 NCBITaxon:3378 property_value: RO:0002161 NCBITaxon:3398 property_value: RO:0002161 NCBITaxon:4751 property_value: RO:0002161 NCBITaxon:5782 [Term] id: GO:0060479 name: lung cell differentiation namespace: biological_process def: "The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features of a mature cell found in the lung. Differentiation includes the processes involved in commitment of a cell to a specific fate." [GOC:dph, GOC:mtg_lung] synonym: "pulmonary cell differentiation" EXACT [GOC:dph] is_a: GO:0030154 ! cell differentiation relationship: BFO:0000050 GO:0030324 ! part of lung development [Term] id: GO:0060480 name: lung goblet cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a lung goblet cell. A goblet cell is a cell of the epithelial lining that produces and secretes mucins." [GOC:dph, GOC:mtg_lung] synonym: "pulmonary goblet cell differentiation" EXACT [] is_a: GO:0061140 ! lung secretory cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:1000143 ! results in acquisition of features of lung goblet cell relationship: BFO:0000050 GO:0060481 ! part of lobar bronchus epithelium development relationship: RO:0002315 CL:1000143 ! results in acquisition of features of lung goblet cell [Term] id: GO:0060481 name: lobar bronchus epithelium development namespace: biological_process def: "The biological process whose specific outcome is the progression of a lobar bronchus epithelium from an initial condition to its mature state. This process begins with the formation of the lobar bronchus epithelium and ends with the mature structure. The lobar bronchus epithelium is the tissue made up of epithelial cells that lines the inside of the lobar bronchus." [GOC:dph, GOC:mtg_lung] is_a: GO:0060428 ! lung epithelium development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0002339 ! results in development of epithelium of lobar bronchus relationship: BFO:0000050 GO:0060482 ! part of lobar bronchus development relationship: RO:0002296 UBERON:0002339 ! results in development of epithelium of lobar bronchus [Term] id: GO:0060482 name: lobar bronchus development namespace: biological_process def: "The biological process whose specific outcome is the progression of a lobar bronchus from an initial condition to its mature state. This process begins with the formation of the lobar bronchus and ends with the mature structure. The lobar bronchus is the major airway within the respiratory tree that starts by division of the principal bronchi on both sides and ends at the point of its own subdivision into tertiary or segmental bronchi." [GOC:dph, GOC:mtg_lung] is_a: GO:0060433 ! bronchus development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0002183 ! results in development of lobar bronchus relationship: RO:0002162 NCBITaxon:7776 ! in taxon Gnathostomata relationship: RO:0002296 UBERON:0002183 ! results in development of lobar bronchus [Term] id: GO:0060483 name: lobar bronchus mesenchyme development namespace: biological_process def: "The biological process whose specific outcome is the progression of a lobar bronchus mesenchyme from an initial condition to its mature state. This process begins with the formation of the lobar bronchus mesenchyme and ends with the mature structure. The lobar bronchus mesenchyme is the mass of tissue composed of mesenchymal cells in the lobar bronchus." [GOC:dph, GOC:mtg_lung] is_a: GO:0060484 ! lung-associated mesenchyme development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0004884 ! results in development of lobar bronchus mesenchyme relationship: BFO:0000050 GO:0060482 ! part of lobar bronchus development relationship: RO:0002296 UBERON:0004884 ! results in development of lobar bronchus mesenchyme [Term] id: GO:0060484 name: lung-associated mesenchyme development namespace: biological_process def: "The biological process whose specific outcome is the progression of a lung-associated mesenchyme from an initial condition to its mature state. This process begins with the formation of lung-associated mesenchyme and ends with the mature structure. Lung-associated mesenchyme is the tissue made up of loosely connected mesenchymal cells in the lung." [GOC:dph, GOC:mtg_lung] synonym: "lung mesenchyme development" EXACT [GOC:dph] synonym: "pulmonary mesenchyme development" EXACT [GOC:dph] is_a: GO:0060485 ! mesenchyme development relationship: BFO:0000050 GO:0030324 ! part of lung development [Term] id: GO:0060485 name: mesenchyme development namespace: biological_process def: "The process whose specific outcome is the progression of a mesenchymal tissue over time, from its formation to the mature structure. A mesenchymal tissue is made up of loosely packed stellate cells." [GOC:dph] synonym: "mesenchymal development" EXACT [GOC:dph] is_a: GO:0009888 ! tissue development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0003104 ! results in development of mesenchyme relationship: BFO:0000050 GO:0048513 ! part of animal organ development relationship: RO:0002162 NCBITaxon:6072 ! in taxon Eumetazoa relationship: RO:0002296 UBERON:0003104 ! results in development of mesenchyme [Term] id: GO:0060486 name: club cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a club cell. A club cell is an unciliated epithelial cell found in the respiratory and terminal bronchioles." [GOC:dph, GOC:mtg_lung, PMID:28144783] synonym: "Clara cell differentiation" EXACT [PMID:28144783] is_a: GO:0060487 ! lung epithelial cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000158 ! results in acquisition of features of club cell relationship: RO:0002315 CL:0000158 ! results in acquisition of features of club cell [Term] id: GO:0060487 name: lung epithelial cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of an epithelial cell that contributes to the epithelium of the lung." [GOC:dph] synonym: "pulmonary epithelial cell differentiation" RELATED [GOC:dph] is_a: GO:0030855 ! epithelial cell differentiation is_a: GO:0060479 ! lung cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000082 ! results in acquisition of features of epithelial cell of lung relationship: BFO:0000050 GO:0060428 ! part of lung epithelium development relationship: RO:0002315 CL:0000082 ! results in acquisition of features of epithelial cell of lung [Term] id: GO:0060490 name: lateral sprouting involved in lung morphogenesis namespace: biological_process def: "The process in which a branch forms along the side of the lung epithelial tube." [GOC:dph, GOC:mtg_lung] is_a: GO:0060601 ! lateral sprouting from an epithelium intersection_of: GO:0060601 ! lateral sprouting from an epithelium intersection_of: BFO:0000050 GO:0060441 ! part of epithelial tube branching involved in lung morphogenesis relationship: BFO:0000050 GO:0060441 ! part of epithelial tube branching involved in lung morphogenesis [Term] id: GO:0060491 name: regulation of cell projection assembly namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of cell projection assembly." [GOC:dph, GOC:tb] synonym: "regulation of cell projection formation" RELATED [GOC:dph, GOC:tb] is_a: GO:0031344 ! regulation of cell projection organization is_a: GO:0044087 ! regulation of cellular component biogenesis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0030031 ! regulates cell projection assembly relationship: RO:0002211 GO:0030031 ! regulates cell projection assembly [Term] id: GO:0060495 name: cell-cell signaling involved in lung development namespace: biological_process def: "Any process that mediates the transfer of information from one cell to another and contributes to the progression of the lung, from its initial state to the mature structure." [GOC:dph, GOC:mtg_lung] synonym: "cell-cell signalling involved in lung development" EXACT [GOC:mah] is_a: GO:0007267 ! cell-cell signaling intersection_of: GO:0007267 ! cell-cell signaling intersection_of: BFO:0000050 GO:0030324 ! part of lung development relationship: BFO:0000050 GO:0030324 ! part of lung development [Term] id: GO:0060496 name: mesenchymal-epithelial cell signaling involved in lung development namespace: biological_process def: "Any process that mediates the transfer of information from a mesenchymal cell to an epithelial cell and contributes to the development of the lung." [GOC:dph, GOC:mtg_lung] synonym: "mesenchymal-epithelial cell signalling involved in lung development" EXACT [GOC:mah] is_a: GO:0060495 ! cell-cell signaling involved in lung development is_a: GO:0060638 ! mesenchymal-epithelial cell signaling intersection_of: GO:0060638 ! mesenchymal-epithelial cell signaling intersection_of: BFO:0000050 GO:0030324 ! part of lung development [Term] id: GO:0060497 name: mesenchymal-endodermal cell signaling namespace: biological_process def: "Any process that mediates the transfer of information between a mesenchymal cell and an endodermal cell." [GOC:dph] synonym: "mesenchymal-endodermal cell signalling" EXACT [GOC:mah] is_a: GO:0007267 ! cell-cell signaling intersection_of: GO:0007267 ! cell-cell signaling intersection_of: RO:0002231 CL:0008019 ! has start location mesenchymal cell intersection_of: RO:0002232 CL:0000223 ! has end location endodermal cell relationship: RO:0002231 CL:0008019 ! has start location mesenchymal cell relationship: RO:0002232 CL:0000223 ! has end location endodermal cell [Term] id: GO:0060501 name: positive regulation of epithelial cell proliferation involved in lung morphogenesis namespace: biological_process def: "Any process that increases the rate or frequency of epithelial cell proliferation that results in the lung attaining its shape." [GOC:dph] is_a: GO:0050679 ! positive regulation of epithelial cell proliferation is_a: GO:2000794 ! regulation of epithelial cell proliferation involved in lung morphogenesis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0060502 ! positively regulates epithelial cell proliferation involved in lung morphogenesis relationship: RO:0002213 GO:0060502 ! positively regulates epithelial cell proliferation involved in lung morphogenesis [Term] id: GO:0060502 name: epithelial cell proliferation involved in lung morphogenesis namespace: biological_process def: "The multiplication or reproduction of epithelial cells, resulting in the expansion of a cell population that contributes to the shaping of the lung." [GOC:dph] is_a: GO:0050673 ! epithelial cell proliferation intersection_of: GO:0050673 ! epithelial cell proliferation intersection_of: BFO:0000050 GO:0060425 ! part of lung morphogenesis relationship: BFO:0000050 GO:0060425 ! part of lung morphogenesis relationship: BFO:0000050 GO:0060428 ! part of lung epithelium development [Term] id: GO:0060509 name: type I pneumocyte differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a type I pneumocyte. A type I pneumocyte is a flattened cell with greatly attenuated cytoplasm and a paucity of organelles." [GOC:dph, GOC:mtg_lung, ISBN:0721662544] synonym: "membranous pneumocyte differentiation" EXACT [GOC:dph, ISBN:0721662544] synonym: "small alveolar cell differentiation" RELATED [GOC:dph, ISBN:0721662544] synonym: "squamous alveolar cell differentiation" RELATED [GOC:dph, ISBN:0721662544] is_a: GO:0060487 ! lung epithelial cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0002062 ! results in acquisition of features of pulmonary alveolar type 1 cell relationship: RO:0002315 CL:0002062 ! results in acquisition of features of pulmonary alveolar type 1 cell [Term] id: GO:0060510 name: type II pneumocyte differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a type II pneumocyte. A type II pneumocyte is a surfactant secreting cell that contains abundant cytoplasm containing numerous lipid-rich multilamellar bodies." [GOC:dph, GOC:mtg_lung, ISBN:0721662544] synonym: "granular pneumocyte differentiation" RELATED [GOC:dph, ISBN:0721662544] synonym: "great alveolar cell differentiation" EXACT [GOC:dph, ISBN:0721662544] synonym: "large alveolar cell differentiation" RELATED [GOC:dph, ISBN:0721662544] is_a: GO:0061140 ! lung secretory cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0002063 ! results in acquisition of features of pulmonary alveolar type 2 cell relationship: RO:0002315 CL:0002063 ! results in acquisition of features of pulmonary alveolar type 2 cell [Term] id: GO:0060512 name: prostate gland morphogenesis namespace: biological_process def: "The process in which the anatomical structures of a prostate gland are generated and organized." [GOC:dph, PMID:18977204] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0022612 ! gland morphogenesis intersection_of: GO:0022612 ! gland morphogenesis intersection_of: RO:0002298 UBERON:0002367 ! results in morphogenesis of prostate gland relationship: BFO:0000050 GO:0030850 ! part of prostate gland development relationship: RO:0002298 UBERON:0002367 ! results in morphogenesis of prostate gland [Term] id: GO:0060513 name: prostatic bud formation namespace: biological_process def: "The morphogenetic process in which a region of the fetal urogenital sinus epithelium is specified to become the prostate, resulting in prostate bud outgrowth." [GOC:dph, PMID:18977204] synonym: "primary prostate bud formation" EXACT [GOC:dph] synonym: "prostate ductal budding" EXACT [GOC:dph, PMID:11401393] synonym: "prostate gland formation" EXACT [GOC:dph] is_a: GO:0016331 ! morphogenesis of embryonic epithelium is_a: GO:0048645 ! animal organ formation is_a: GO:0060572 ! morphogenesis of an epithelial bud is_a: GO:0060601 ! lateral sprouting from an epithelium is_a: GO:0060740 ! prostate gland epithelium morphogenesis intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0003820 ! results in formation of anatomical entity prostate bud relationship: RO:0002297 UBERON:0003820 ! results in formation of anatomical entity prostate bud [Term] id: GO:0060525 name: prostate glandular acinus development namespace: biological_process def: "The progression of a glandular acinus of the prostate gland over time, from its initial formation to the mature structure. The glandular acini are the saclike structures of the gland." [GOC:dph, PMID:18977204] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0048856 ! anatomical structure development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0004179 ! results in development of prostate glandular acinus relationship: BFO:0000050 GO:0030850 ! part of prostate gland development relationship: RO:0002296 UBERON:0004179 ! results in development of prostate glandular acinus [Term] id: GO:0060526 name: prostate glandular acinus morphogenesis namespace: biological_process def: "The process in which the prostate glandular acini are generated and organized. The glandular acini are the saclike structures of the gland." [GOC:dph] is_a: GO:0060740 ! prostate gland epithelium morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0004179 ! results in morphogenesis of prostate glandular acinus relationship: BFO:0000050 GO:0060525 ! part of prostate glandular acinus development relationship: RO:0002298 UBERON:0004179 ! results in morphogenesis of prostate glandular acinus [Term] id: GO:0060530 name: smooth muscle cell differentiation involved in prostate glandular acinus development namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a smooth muscle cell of the prostate glandular acinus." [GOC:dph, PMID:18977204] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0051145 ! smooth muscle cell differentiation intersection_of: GO:0051145 ! smooth muscle cell differentiation intersection_of: BFO:0000050 GO:0060525 ! part of prostate glandular acinus development relationship: BFO:0000050 GO:0060525 ! part of prostate glandular acinus development [Term] id: GO:0060531 name: neuroendocrine cell differentiation involved in prostate gland acinus development namespace: biological_process def: "The process in which relatively unspecialized cells acquires specialized structural and functions of a neuroendocrine cell of the prostate gland acinus." [GOC:dph, PMID:18977204] is_a: GO:0060742 ! epithelial cell differentiation involved in prostate gland development is_a: GO:0061101 ! neuroendocrine cell differentiation intersection_of: GO:0061101 ! neuroendocrine cell differentiation intersection_of: BFO:0000050 GO:0060525 ! part of prostate glandular acinus development relationship: BFO:0000050 GO:0060525 ! part of prostate glandular acinus development [Term] id: GO:0060532 name: bronchus cartilage development namespace: biological_process def: "The process whose specific outcome is the progression of lung cartilage over time, from its formation to the mature structure. Cartilage is a connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate." [GOC:dph, GOC:mtg_lung] synonym: "pulmonary cartilage development" EXACT [] is_a: GO:0051216 ! cartilage development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0001956 ! results in development of cartilage of bronchus relationship: BFO:0000050 GO:0060433 ! part of bronchus development relationship: RO:0002296 UBERON:0001956 ! results in development of cartilage of bronchus creation_date: 2009-04-10T08:12:06Z [Term] id: GO:0060533 name: bronchus cartilage morphogenesis namespace: biological_process def: "The process in which the bronchus cartilage is generated and organized. The bronchus cartilage is the connective tissue of the portion of the airway that connects to the lungs." [GOC:dph] is_a: GO:0060536 ! cartilage morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0001956 ! results in morphogenesis of cartilage of bronchus relationship: BFO:0000050 GO:0060434 ! part of bronchus morphogenesis relationship: BFO:0000050 GO:0060532 ! part of bronchus cartilage development relationship: RO:0002298 UBERON:0001956 ! results in morphogenesis of cartilage of bronchus creation_date: 2009-04-10T08:47:41Z [Term] id: GO:0060534 name: trachea cartilage development namespace: biological_process def: "The process whose specific outcome is the progression of the tracheal cartilage over time, from its formation to the mature structure. Cartilage is a connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate." [GOC:dph] is_a: GO:0051216 ! cartilage development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0003604 ! results in development of trachea cartilage relationship: BFO:0000050 GO:0060438 ! part of trachea development relationship: RO:0002296 UBERON:0003604 ! results in development of trachea cartilage creation_date: 2009-04-10T09:00:18Z [Term] id: GO:0060535 name: trachea cartilage morphogenesis namespace: biological_process def: "The process in which the anatomical structures of cartilage in the trachea are generated and organized." [GOC:dph] is_a: GO:0060536 ! cartilage morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0003604 ! results in morphogenesis of trachea cartilage relationship: BFO:0000050 GO:0060439 ! part of trachea morphogenesis relationship: BFO:0000050 GO:0060534 ! part of trachea cartilage development relationship: RO:0002298 UBERON:0003604 ! results in morphogenesis of trachea cartilage creation_date: 2009-04-10T09:07:48Z [Term] id: GO:0060536 name: cartilage morphogenesis namespace: biological_process def: "The process in which the anatomical structures of cartilage are generated and organized." [GOC:dph] is_a: GO:0009887 ! animal organ morphogenesis is_a: GO:0048729 ! tissue morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0007844 ! results in morphogenesis of cartilage element relationship: BFO:0000050 GO:0051216 ! part of cartilage development relationship: RO:0002298 UBERON:0007844 ! results in morphogenesis of cartilage element creation_date: 2009-04-10T09:13:27Z [Term] id: GO:0060537 name: muscle tissue development namespace: biological_process def: "The progression of muscle tissue over time, from its initial formation to its mature state. Muscle tissue is a contractile tissue made up of actin and myosin fibers." [GOC:dph] is_a: GO:0009888 ! tissue development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0002385 ! results in development of muscle tissue relationship: RO:0002296 UBERON:0002385 ! results in development of muscle tissue creation_date: 2009-04-10T08:05:37Z [Term] id: GO:0060538 name: skeletal muscle organ development namespace: biological_process def: "The progression of a skeletal muscle organ over time from its initial formation to its mature state. A skeletal muscle organ includes the skeletal muscle tissue and its associated connective tissue." [GOC:dph] is_a: GO:0007517 ! muscle organ development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0014892 ! results in development of skeletal muscle organ, vertebrate relationship: RO:0002162 NCBITaxon:7742 ! in taxon Vertebrata relationship: RO:0002296 UBERON:0014892 ! results in development of skeletal muscle organ, vertebrate creation_date: 2009-04-10T08:25:12Z [Term] id: GO:0060539 name: diaphragm development namespace: biological_process def: "The progression of the diaphragm over time from its initial formation to the mature structure. The diaphragm is a skeletal muscle that is responsible for contraction and expansion of the lungs." [GOC:dph] is_a: GO:0060538 ! skeletal muscle organ development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0001103 ! results in development of diaphragm relationship: BFO:0000050 GO:0060541 ! part of respiratory system development relationship: RO:0002162 NCBITaxon:40674 ! in taxon Mammalia relationship: RO:0002296 UBERON:0001103 ! results in development of diaphragm creation_date: 2009-04-10T08:44:56Z [Term] id: GO:0060540 name: diaphragm morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the diaphragm are generated and organized." [GOC:dph] is_a: GO:0048644 ! muscle organ morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0001103 ! results in morphogenesis of diaphragm relationship: BFO:0000050 GO:0060539 ! part of diaphragm development relationship: RO:0002298 UBERON:0001103 ! results in morphogenesis of diaphragm creation_date: 2009-04-10T08:47:51Z [Term] id: GO:0060541 name: respiratory system development namespace: biological_process def: "The progression of the respiratory system over time from its formation to its mature structure. The respiratory system carries out respiratory gaseous exchange." [GOC:dph] subset: goslim_drosophila is_a: GO:0048731 ! system development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0001004 ! results in development of respiratory system relationship: RO:0002296 UBERON:0001004 ! results in development of respiratory system creation_date: 2009-04-10T08:55:42Z [Term] id: GO:0060560 name: developmental growth involved in morphogenesis namespace: biological_process def: "The increase in size or mass of an anatomical structure that contributes to the structure attaining its shape." [GOC:dph] synonym: "differential growth" EXACT [GOC:dph] is_a: GO:0048589 ! developmental growth intersection_of: GO:0048589 ! developmental growth intersection_of: BFO:0000050 GO:0009653 ! part of anatomical structure morphogenesis relationship: BFO:0000050 GO:0009653 ! part of anatomical structure morphogenesis creation_date: 2009-04-28T08:42:53Z [Term] id: GO:0060561 name: apoptotic process involved in morphogenesis namespace: biological_process def: "Any apoptotic process that contributes to the shaping of an anatomical structure." [GOC:dph, GOC:mtg_apoptosis] synonym: "apoptosis involved in development" RELATED [] synonym: "apoptosis involved in morphogenesis" NARROW [] synonym: "morphogenetic apoptosis" RELATED [GOC:dph] is_a: GO:1902742 ! apoptotic process involved in development intersection_of: GO:0006915 ! apoptotic process intersection_of: BFO:0000050 GO:0009653 ! part of anatomical structure morphogenesis relationship: BFO:0000050 GO:0009653 ! part of anatomical structure morphogenesis property_value: RO:0002161 NCBITaxon:4896 creation_date: 2009-04-28T09:17:27Z [Term] id: GO:0060562 name: epithelial tube morphogenesis namespace: biological_process def: "The process in which the anatomical structures of a tube are generated and organized from an epithelium. Epithelial tubes transport gases, liquids and cells from one site to another and form the basic structure of many organs and tissues, with tube shape and organization varying from the single-celled excretory organ in Caenorhabditis elegans to the branching trees of the mammalian kidney and insect tracheal system." [GOC:dph] is_a: GO:0002009 ! morphogenesis of an epithelium is_a: GO:0035239 ! tube morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0003914 ! results in morphogenesis of epithelial tube relationship: RO:0002298 UBERON:0003914 ! results in morphogenesis of epithelial tube creation_date: 2009-04-28T09:33:36Z [Term] id: GO:0060563 name: neuroepithelial cell differentiation namespace: biological_process def: "The process in which epiblast cells acquire specialized features of neuroepithelial cells." [GOC:dph, GOC:tb] is_a: GO:0002065 ! columnar/cuboidal epithelial cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000710 ! results in acquisition of features of neurecto-epithelial cell relationship: RO:0002315 CL:0000710 ! results in acquisition of features of neurecto-epithelial cell creation_date: 2009-04-29T01:50:05Z [Term] id: GO:0060568 name: regulation of peptide hormone processing namespace: biological_process def: "Any process that modulates the rate, frequency or extent of peptide hormone processing. Peptide hormone processing is the generation of a mature peptide hormone by posttranslational processing of a prohormone." [GOC:dph, GOC:tb] is_a: GO:0032350 ! regulation of hormone metabolic process is_a: GO:0034248 ! regulation of amide metabolic process is_a: GO:0070613 ! regulation of protein processing intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0016486 ! regulates peptide hormone processing relationship: RO:0002211 GO:0016486 ! regulates peptide hormone processing property_value: RO:0002161 NCBITaxon:4895 creation_date: 2009-04-29T03:16:05Z [Term] id: GO:0060569 name: positive regulation of peptide hormone processing namespace: biological_process def: "Any process that increases the rate, frequency or extent of peptide hormone processing. Peptide hormone processing is the generation of a mature peptide hormone by posttranslational processing of a prohormone." [GOC:dph, GOC:tb] is_a: GO:0010954 ! positive regulation of protein processing is_a: GO:0032352 ! positive regulation of hormone metabolic process is_a: GO:0034250 ! positive regulation of amide metabolic process is_a: GO:0060568 ! regulation of peptide hormone processing intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0016486 ! positively regulates peptide hormone processing relationship: RO:0002213 GO:0016486 ! positively regulates peptide hormone processing property_value: RO:0002161 NCBITaxon:4895 creation_date: 2009-04-29T03:22:05Z [Term] id: GO:0060570 name: negative regulation of peptide hormone processing namespace: biological_process def: "Any process that decreases the rate, frequency or extent of peptide hormone processing. Peptide hormone processing is the generation of a mature peptide hormone by posttranslational processing of a prohormone." [GOC:dph, GOC:tb] is_a: GO:0010955 ! negative regulation of protein processing is_a: GO:0032351 ! negative regulation of hormone metabolic process is_a: GO:0034249 ! negative regulation of amide metabolic process is_a: GO:0060568 ! regulation of peptide hormone processing intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0016486 ! negatively regulates peptide hormone processing relationship: RO:0002212 GO:0016486 ! negatively regulates peptide hormone processing property_value: RO:0002161 NCBITaxon:4895 creation_date: 2009-04-29T03:24:55Z [Term] id: GO:0060571 name: morphogenesis of an epithelial fold namespace: biological_process def: "The morphogenetic process in which an epithelial sheet bends along a linear axis." [GOC:dph] synonym: "epithelial folding" EXACT [GOC:dph] synonym: "folding of an epithelial sheet" RELATED [GOC:dph] is_a: GO:0002009 ! morphogenesis of an epithelium intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0005157 ! results in morphogenesis of epithelial fold relationship: RO:0002298 UBERON:0005157 ! results in morphogenesis of epithelial fold creation_date: 2009-04-30T09:27:17Z [Term] id: GO:0060572 name: morphogenesis of an epithelial bud namespace: biological_process def: "The morphogenetic process in which a bud forms from an epithelial sheet. A bud is a protrusion that forms form the sheet by localized folding." [GOC:dph] is_a: GO:0060571 ! morphogenesis of an epithelial fold intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0005153 ! results in morphogenesis of epithelial bud relationship: RO:0002298 UBERON:0005153 ! results in morphogenesis of epithelial bud creation_date: 2009-04-30T09:38:35Z [Term] id: GO:0060574 name: intestinal epithelial cell maturation namespace: biological_process def: "The developmental process, independent of morphogenetic (shape) change, that is required for a columna/cuboidal epithelial cell of the intestine to attain its fully functional state. A columnar/cuboidal epithelial cell of the intestine mature as they migrate from the intestinal crypt to the villus." [GOC:dph, PMID:18824147] is_a: GO:0002069 ! columnar/cuboidal epithelial cell maturation intersection_of: GO:0021700 ! developmental maturation intersection_of: RO:0002299 CL:0002563 ! results in maturation of intestinal epithelial cell relationship: BFO:0000050 GO:0060576 ! part of intestinal epithelial cell development relationship: RO:0002299 CL:0002563 ! results in maturation of intestinal epithelial cell creation_date: 2009-05-06T08:10:41Z [Term] id: GO:0060575 name: intestinal epithelial cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a columnar/cuboidal epithelial cell of the intestine." [GOC:dph] is_a: GO:0002065 ! columnar/cuboidal epithelial cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0002563 ! results in acquisition of features of intestinal epithelial cell relationship: BFO:0000050 GO:0048565 ! part of digestive tract development relationship: RO:0002315 CL:0002563 ! results in acquisition of features of intestinal epithelial cell creation_date: 2009-05-06T08:17:56Z [Term] id: GO:0060576 name: intestinal epithelial cell development namespace: biological_process def: "The process whose specific outcome is the progression of a columnar/cuboidal epithelial cell of the intestine over time, from its formation to the mature structure." [GOC:dph] is_a: GO:0002066 ! columnar/cuboidal epithelial cell development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 CL:0002563 ! results in development of intestinal epithelial cell relationship: BFO:0000050 GO:0060575 ! part of intestinal epithelial cell differentiation relationship: RO:0002296 CL:0002563 ! results in development of intestinal epithelial cell creation_date: 2009-05-06T08:20:24Z [Term] id: GO:0060577 name: pulmonary vein morphogenesis namespace: biological_process def: "The process in which the anatomical structure of the pulmonary venous blood vessels are generated and organized. Pulmonary veins are blood vessels that transport blood from the lungs to the heart." [GOC:dph] synonym: "pulmonary venous blood vessel morphogenesis" RELATED [GOC:dph] is_a: GO:0048845 ! venous blood vessel morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0002016 ! results in morphogenesis of pulmonary vein relationship: RO:0002298 UBERON:0002016 ! results in morphogenesis of pulmonary vein creation_date: 2009-05-06T08:44:04Z [Term] id: GO:0060578 name: superior vena cava morphogenesis namespace: biological_process def: "The process in which the anatomical structure of superior vena cava generated and organized. The superior vena cava is a blood vessel that transports blood from the upper body to the heart." [GOC:dph] is_a: GO:0048845 ! venous blood vessel morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0001585 ! results in morphogenesis of anterior vena cava relationship: RO:0002298 UBERON:0001585 ! results in morphogenesis of anterior vena cava creation_date: 2009-05-06T08:47:21Z [Term] id: GO:0060581 name: cell fate commitment involved in pattern specification namespace: biological_process def: "The commitment of cells to specific cell fates and their capacity to differentiate into particular kinds of cells within a field of cells that will exhibit a certain pattern of differentiation. Positional information is established through protein signals that emanate from a localized source within a developmental field resulting in specification of a cell type. Those signals are then interpreted in a cell-autonomous manner resulting in the determination of the cell type." [GOC:dph] is_a: GO:0045165 ! cell fate commitment intersection_of: GO:0045165 ! cell fate commitment intersection_of: BFO:0000050 GO:0007389 ! part of pattern specification process relationship: BFO:0000050 GO:0007389 ! part of pattern specification process property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 creation_date: 2009-05-07T12:40:55Z [Term] id: GO:0060586 name: multicellular organismal-level iron ion homeostasis namespace: biological_process def: "A chemical homeostatic process involved in the maintenance of a steady state level of iron within extracellular body fluids, such as blood, xylem or phloem, of a multicellular organism. This is distinct from maintenance of cellular homeostasis, which occurs within a cell." [PMID:31431773] synonym: "multicellular organismal iron ion homeostasis" EXACT [] is_a: GO:0055080 ! monoatomic cation homeostasis is_a: GO:0098771 ! inorganic ion homeostasis is_a: GO:0140962 ! multicellular organismal-level chemical homeostasis intersection_of: GO:0048871 ! multicellular organismal-level homeostasis intersection_of: RO:0002332 CHEBI:24875 ! regulates levels of relationship: RO:0002332 CHEBI:24875 ! regulates levels of property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/24554" xsd:anyURI property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 creation_date: 2009-05-08T02:18:21Z [Term] id: GO:0060591 name: chondroblast differentiation namespace: biological_process def: "The process in which a mesenchymal cell, acquires specialized structural and/or functional features of a chondroblast. Differentiation includes the processes involved in commitment of a cell to a chondroblast fate. A chondroblast is a precursor cell to chondrocytes." [GOC:dph] synonym: "chondrocyte progenitor cell differentiation" RELATED [GOC:dph] is_a: GO:0030154 ! cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000058 ! results in acquisition of features of chondroblast relationship: BFO:0000050 GO:0051216 ! part of cartilage development relationship: RO:0002315 CL:0000058 ! results in acquisition of features of chondroblast creation_date: 2009-05-11T07:47:36Z [Term] id: GO:0060592 name: mammary gland formation namespace: biological_process def: "The process pertaining to the initial formation of the mammary gland from unspecified parts. The process begins with formation of the mammary line and ends when the solid mammary bud invades the primary mammary mesenchyme." [GOC:dph, PMID:16168142, PMID:17120154] synonym: "mammary bud formation" RELATED [GOC:dph] synonym: "mammary line formation" NARROW [GOC:dph] synonym: "mammary placode formation" NARROW [GOC:dph] synonym: "mammary sprout formation" RELATED [GOC:dph] is_a: BFO:0000003 is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0001911 ! results in formation of anatomical entity mammary gland relationship: BFO:0000050 GO:0060443 ! part of mammary gland morphogenesis relationship: RO:0002297 UBERON:0001911 ! results in formation of anatomical entity mammary gland creation_date: 2009-05-13T08:47:52Z [Term] id: GO:0060596 name: mammary placode formation namespace: biological_process def: "The developmental process in which the mammary placode forms. The mammary placode is a transient lens shaped structure that will give rise to the mammary bud proper." [GOC:dph, PMID:16168142] is_a: GO:0060788 ! ectodermal placode formation intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0005311 ! results in formation of anatomical entity mammary placode relationship: BFO:0000050 GO:0060592 ! part of mammary gland formation relationship: RO:0002297 UBERON:0005311 ! results in formation of anatomical entity mammary placode creation_date: 2009-05-13T11:55:20Z [Term] id: GO:0060599 name: lateral sprouting involved in mammary gland duct morphogenesis namespace: biological_process def: "The process in which a branch forms along the side of a mammary duct." [GOC:dph, PMID:17120154] synonym: "mammary gland duct secondary branching" EXACT [GOC:dph] is_a: GO:0060601 ! lateral sprouting from an epithelium intersection_of: GO:0060601 ! lateral sprouting from an epithelium intersection_of: BFO:0000050 GO:0060444 ! part of branching involved in mammary gland duct morphogenesis relationship: BFO:0000050 GO:0060444 ! part of branching involved in mammary gland duct morphogenesis creation_date: 2009-05-13T12:38:06Z [Term] id: GO:0060601 name: lateral sprouting from an epithelium namespace: biological_process def: "The process in which a branch forms along the side of an epithelium." [GOC:dph] is_a: GO:0002009 ! morphogenesis of an epithelium relationship: BFO:0000050 GO:0061138 ! part of morphogenesis of a branching epithelium creation_date: 2009-05-14T02:33:01Z [Term] id: GO:0060603 name: mammary gland duct morphogenesis namespace: biological_process def: "The process in which anatomical structures of the mammary ducts are generated and organized. Mammary ducts are epithelial tubes that transport milk." [GOC:dph, PMID:17120154] is_a: GO:0060562 ! epithelial tube morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0001765 ! results in morphogenesis of mammary duct relationship: BFO:0000050 GO:0060443 ! part of mammary gland morphogenesis relationship: BFO:0000050 GO:0061180 ! part of mammary gland epithelium development relationship: RO:0002298 UBERON:0001765 ! results in morphogenesis of mammary duct creation_date: 2009-05-15T09:22:25Z [Term] id: GO:0060610 name: mesenchymal cell differentiation involved in mammary gland development namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a mammary gland mesenchymal cell. Mammary gland mesenchymal cells form a loosely connected network of cells that surround the mammary ducts." [GOC:dph] synonym: "mammary gland mesenchymal cell differentiation" EXACT [GOC:dph] is_a: GO:0048762 ! mesenchymal cell differentiation intersection_of: GO:0048762 ! mesenchymal cell differentiation intersection_of: BFO:0000050 GO:0030879 ! part of mammary gland development relationship: BFO:0000050 GO:0030879 ! part of mammary gland development creation_date: 2009-05-15T12:17:06Z [Term] id: GO:0060611 name: mammary gland fat development namespace: biological_process def: "The progression of the mammary gland fat over time, from its formation to the mature structure. The mammary fat is an adipose structure in the gland that is invaded by the mammary ducts." [GOC:dph] is_a: GO:0060612 ! adipose tissue development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0004180 ! results in development of mammary gland fat relationship: BFO:0000050 GO:0030879 ! part of mammary gland development relationship: RO:0002296 UBERON:0004180 ! results in development of mammary gland fat creation_date: 2009-05-15T12:27:57Z [Term] id: GO:0060612 name: adipose tissue development namespace: biological_process def: "The process whose specific outcome is the progression of adipose tissue over time, from its formation to the mature structure. Adipose tissue is specialized tissue that is used to store fat." [GOC:dph] synonym: "adipogenesis" RELATED [GOC:mah, GOC:sl] is_a: GO:0061448 ! connective tissue development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0001013 ! results in development of adipose tissue relationship: BFO:0000050 GO:0048513 ! part of animal organ development relationship: RO:0002296 UBERON:0001013 ! results in development of adipose tissue creation_date: 2009-05-15T12:36:28Z [Term] id: GO:0060615 name: mammary gland bud formation namespace: biological_process def: "The morphogenetic process in which a bud forms from the mammary placode. A mammary bud is bulb of epithelial cells that is distinct from the surrounding epidermis." [GOC:dph, PMID:12558599] is_a: GO:0016331 ! morphogenesis of embryonic epithelium is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0005333 ! results in formation of anatomical entity mammary bud relationship: BFO:0000050 GO:0060648 ! part of mammary gland bud morphogenesis relationship: RO:0002297 UBERON:0005333 ! results in formation of anatomical entity mammary bud creation_date: 2009-05-18T08:43:14Z [Term] id: GO:0060616 name: mammary gland cord formation namespace: biological_process def: "The process in which the mammary gland cord forms by elongation of the mammary bud. The cord is formed once the elongating bud breaks through the mesenchyme and reaches the fat pad." [GOC:dph, PMID:12558599] synonym: "mammary gland sprout formation" EXACT [GOC:dph] is_a: GO:0016331 ! morphogenesis of embryonic epithelium is_a: GO:0072175 ! epithelial tube formation intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0004182 ! results in formation of anatomical entity mammary gland cord relationship: BFO:0000050 GO:0060652 ! part of mammary gland cord morphogenesis relationship: RO:0002297 UBERON:0004182 ! results in formation of anatomical entity mammary gland cord creation_date: 2009-05-18T08:57:58Z [Term] id: GO:0060618 name: nipple development namespace: biological_process def: "The progression of the nipple over time, from its formation to the mature structure. The nipple is a part of the mammary gland that protrudes from the surface ectoderm." [GOC:dph] is_a: GO:0048856 ! anatomical structure development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0002030 ! results in development of nipple relationship: BFO:0000050 GO:0030879 ! part of mammary gland development relationship: RO:0002296 UBERON:0002030 ! results in development of nipple creation_date: 2009-05-18T09:29:38Z [Term] id: GO:0060619 name: cell migration involved in mammary placode formation namespace: biological_process def: "The orderly movement of epithelial cells within the mammary line that contributes to the formation of the mammary placode." [GOC:dph, PMID:12558599] is_a: GO:0010631 ! epithelial cell migration intersection_of: GO:0016477 ! cell migration intersection_of: BFO:0000050 GO:0060596 ! part of mammary placode formation relationship: BFO:0000050 GO:0060596 ! part of mammary placode formation creation_date: 2009-05-18T09:41:49Z [Term] id: GO:0060623 name: regulation of chromosome condensation namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of chromosome condensation, the progressive compaction of dispersed interphase chromatin into threadlike chromosomes prior to mitotic or meiotic nuclear division, or during apoptosis, in eukaryotic cells." [GOC:dph, GOC:tb] is_a: GO:0033044 ! regulation of chromosome organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0030261 ! regulates chromosome condensation relationship: RO:0002211 GO:0030261 ! regulates chromosome condensation creation_date: 2009-05-18T02:12:13Z [Term] id: GO:0060627 name: regulation of vesicle-mediated transport namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of vesicle-mediated transport, the directed movement of substances, either within a vesicle or in the vesicle membrane, into, out of or within a cell." [GOC:dph, GOC:tb] is_a: GO:0050794 ! regulation of cellular process is_a: GO:0051049 ! regulation of transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0016192 ! regulates vesicle-mediated transport relationship: RO:0002211 GO:0016192 ! regulates vesicle-mediated transport creation_date: 2009-05-18T02:29:43Z [Term] id: GO:0060632 name: regulation of microtubule-based movement namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of microtubule-based movement, the movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins." [GOC:dph, GOC:tb] is_a: GO:0032886 ! regulation of microtubule-based process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0007018 ! regulates microtubule-based movement relationship: RO:0002211 GO:0007018 ! regulates microtubule-based movement creation_date: 2009-05-18T03:07:02Z [Term] id: GO:0060638 name: mesenchymal-epithelial cell signaling namespace: biological_process def: "Any process that mediates the transfer of information from a mesenchymal cell to an epithelial cell where it is received and interpreted." [GOC:dph] synonym: "mesenchymal-epithelial cell signalling" EXACT [GOC:mah] is_a: GO:0007267 ! cell-cell signaling intersection_of: GO:0007267 ! cell-cell signaling intersection_of: RO:0002231 CL:0008019 ! has start location mesenchymal cell intersection_of: RO:0002232 CL:0000066 ! has end location epithelial cell relationship: RO:0002231 CL:0008019 ! has start location mesenchymal cell relationship: RO:0002232 CL:0000066 ! has end location epithelial cell creation_date: 2009-05-19T03:59:05Z [Term] id: GO:0060642 name: white fat cell differentiation involved in mammary gland fat development namespace: biological_process def: "The process in which a preadipocyte acquires specialized features of a white adipocyte of the mammary gland. White adipocytes have cytoplasmic lipids arranged in a unique vacuole." [GOC:dph, PMID:12558599] is_a: GO:0050872 ! white fat cell differentiation intersection_of: GO:0050872 ! white fat cell differentiation intersection_of: BFO:0000050 GO:0060611 ! part of mammary gland fat development relationship: BFO:0000050 GO:0060611 ! part of mammary gland fat development creation_date: 2009-05-27T05:50:56Z [Term] id: GO:0060643 name: epithelial cell differentiation involved in mammary gland bud morphogenesis namespace: biological_process def: "The process in which a cell of the mammary placode becomes a cell of the mammary gland bud." [GOC:dph] is_a: GO:0060644 ! mammary gland epithelial cell differentiation intersection_of: GO:0030855 ! epithelial cell differentiation intersection_of: BFO:0000050 GO:0060648 ! part of mammary gland bud morphogenesis relationship: BFO:0000050 GO:0060615 ! part of mammary gland bud formation creation_date: 2009-05-29T07:58:13Z [Term] id: GO:0060644 name: mammary gland epithelial cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized epithelial cell becomes a more specialized epithelial cell of the mammary gland." [GOC:dph] is_a: GO:0030855 ! epithelial cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0002327 ! results in acquisition of features of mammary gland epithelial cell relationship: BFO:0000050 GO:0061180 ! part of mammary gland epithelium development relationship: RO:0002315 CL:0002327 ! results in acquisition of features of mammary gland epithelial cell creation_date: 2009-05-29T08:03:07Z [Term] id: GO:0060647 name: mesenchymal cell condensation involved in mammary fat development namespace: biological_process def: "The cell adhesion process in which mammary mesenchyme cells adhere to one another in the initial stages of the formation of mammary fat development." [GOC:dph, PMID:12558599] is_a: GO:0098609 ! cell-cell adhesion intersection_of: GO:0098609 ! cell-cell adhesion intersection_of: BFO:0000050 GO:0060611 ! part of mammary gland fat development relationship: BFO:0000050 GO:0060611 ! part of mammary gland fat development creation_date: 2009-05-29T08:33:29Z [Term] id: GO:0060648 name: mammary gland bud morphogenesis namespace: biological_process def: "The process in which anatomical structures of the mammary gland buds are generated and organized. Mammary gland buds form by an outpocketing of the mammary placodes and grow to invade the mammary fat, when they form the mammary cord." [GOC:dph, PMID:12558599] is_a: GO:0060572 ! morphogenesis of an epithelial bud intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0005333 ! results in morphogenesis of mammary bud relationship: BFO:0000050 GO:0060603 ! part of mammary gland duct morphogenesis relationship: RO:0002298 UBERON:0005333 ! results in morphogenesis of mammary bud creation_date: 2009-05-29T08:42:22Z [Term] id: GO:0060652 name: mammary gland cord morphogenesis namespace: biological_process def: "The process in which anatomical structures of the mammary gland cord are generated and organized. Mammary gland cords form when the mammary gland bud invades the mammary fat." [GOC:dph, PMID:12558599] synonym: "mammary gland sprout morphogenesis" EXACT [GOC:dph] is_a: GO:0060562 ! epithelial tube morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0004182 ! results in morphogenesis of mammary gland cord relationship: BFO:0000050 GO:0060603 ! part of mammary gland duct morphogenesis relationship: RO:0002298 UBERON:0004182 ! results in morphogenesis of mammary gland cord creation_date: 2009-05-29T09:06:56Z [Term] id: GO:0060653 name: epithelial cell differentiation involved in mammary gland cord morphogenesis namespace: biological_process def: "The process in which a relatively unspecialized epithelial cell becomes a more specialized epithelial cell of the mammary gland cord. Epithelial cells of the mammary cord give it its funnel-like shape and some are cornified." [GOC:dph, PMID:12558599] synonym: "epithelial cell differentiation involved in mammary gland sprout morphogenesis" RELATED [GOC:dph] is_a: GO:0060644 ! mammary gland epithelial cell differentiation intersection_of: GO:0030855 ! epithelial cell differentiation intersection_of: BFO:0000050 GO:0060652 ! part of mammary gland cord morphogenesis relationship: BFO:0000050 GO:0060652 ! part of mammary gland cord morphogenesis creation_date: 2009-05-29T09:17:16Z [Term] id: GO:0060655 name: branching involved in mammary gland cord morphogenesis namespace: biological_process def: "The process in which the branching structure of the mammary gland cord is generated and organized. The mammary gland cord is a solid epithelial structure that will hollow out, forming the mammary duct." [GOC:dph, PMID:12558599] is_a: GO:0060444 ! branching involved in mammary gland duct morphogenesis intersection_of: GO:0061138 ! morphogenesis of a branching epithelium intersection_of: BFO:0000050 GO:0060652 ! part of mammary gland cord morphogenesis relationship: BFO:0000050 GO:0060652 ! part of mammary gland cord morphogenesis creation_date: 2009-05-29T09:29:32Z [Term] id: GO:0060658 name: nipple morphogenesis namespace: biological_process def: "The process in which the nipple is generated and organized." [GOC:dph] is_a: BFO:0000003 is_a: GO:0009653 ! anatomical structure morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0002030 ! results in morphogenesis of nipple relationship: BFO:0000050 GO:0060443 ! part of mammary gland morphogenesis relationship: BFO:0000050 GO:0060618 ! part of nipple development relationship: RO:0002298 UBERON:0002030 ! results in morphogenesis of nipple creation_date: 2009-05-29T10:45:44Z [Term] id: GO:0060660 name: epidermis morphogenesis involved in nipple formation namespace: biological_process def: "The process in which the epidermis of the nipple sheath is uplifted to form an umbrella-like projection." [GOC:dph, PMID:12558599] is_a: GO:0048730 ! epidermis morphogenesis intersection_of: GO:0048730 ! epidermis morphogenesis intersection_of: BFO:0000050 GO:0060658 ! part of nipple morphogenesis relationship: BFO:0000050 GO:0060658 ! part of nipple morphogenesis creation_date: 2009-05-29T11:04:04Z [Term] id: GO:0060661 name: submandibular salivary gland formation namespace: biological_process def: "The developmental process pertaining to the initial formation of a submandibular salivary gland. This process begins with a thickening of the epithelium next to the tongue and ends when a bud linked to the oral surface is formed." [GOC:dph, PMID:17336109] is_a: BFO:0000003 is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0001736 ! results in formation of anatomical entity submandibular gland relationship: BFO:0000050 GO:0007435 ! part of salivary gland morphogenesis relationship: RO:0002162 NCBITaxon:32524 ! in taxon Amniota relationship: RO:0002297 UBERON:0001736 ! results in formation of anatomical entity submandibular gland creation_date: 2009-06-01T08:07:16Z [Term] id: GO:0060664 name: epithelial cell proliferation involved in salivary gland morphogenesis namespace: biological_process def: "The multiplication or reproduction of epithelial cells of the submandibular salivary gland, resulting in the expansion of a cell population and the shaping of the gland." [GOC:dph, PMID:17336109] is_a: GO:0050673 ! epithelial cell proliferation intersection_of: GO:0050673 ! epithelial cell proliferation intersection_of: BFO:0000050 GO:0007435 ! part of salivary gland morphogenesis relationship: BFO:0000050 GO:0007435 ! part of salivary gland morphogenesis creation_date: 2009-06-01T08:36:13Z [Term] id: GO:0060669 name: embryonic placenta morphogenesis namespace: biological_process def: "The process in which the embryonic placenta is generated and organized." [GOC:dph] is_a: BFO:0000003 is_a: GO:0048598 ! embryonic morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0007106 ! results in morphogenesis of chorionic villus relationship: BFO:0000050 GO:0001892 ! part of embryonic placenta development relationship: RO:0002298 UBERON:0007106 ! results in morphogenesis of chorionic villus creation_date: 2009-06-02T09:33:37Z [Term] id: GO:0060670 name: branching involved in labyrinthine layer morphogenesis namespace: biological_process def: "The process in which the branches of the fetal placental villi are generated and organized. The villous part of the placenta is called the labyrinth layer." [GOC:dph, PMID:16916377] is_a: GO:0048598 ! embryonic morphogenesis is_a: GO:0061138 ! morphogenesis of a branching epithelium intersection_of: GO:0061138 ! morphogenesis of a branching epithelium intersection_of: BFO:0000050 GO:0060713 ! part of labyrinthine layer morphogenesis relationship: BFO:0000050 GO:0060713 ! part of labyrinthine layer morphogenesis creation_date: 2009-06-02T10:40:40Z [Term] id: GO:0060671 name: epithelial cell differentiation involved in embryonic placenta development namespace: biological_process def: "The process in which a trophoblast cell acquires specialized features of an epithelial cell of the placental labyrinthine layer." [GOC:dph, PMID:16916377] is_a: GO:0030855 ! epithelial cell differentiation is_a: GO:0060706 ! cell differentiation involved in embryonic placenta development intersection_of: GO:0030855 ! epithelial cell differentiation intersection_of: BFO:0000050 GO:0001892 ! part of embryonic placenta development relationship: BFO:0000050 GO:0060711 ! part of labyrinthine layer development creation_date: 2009-06-02T11:40:52Z [Term] id: GO:0060673 name: cell-cell signaling involved in placenta development namespace: biological_process def: "Any process that mediates the transfer of information from one cell to another." [GOC:dph, PMID:16916377] synonym: "cell-cell signalling involved in placenta development" EXACT [GOC:mah] is_a: GO:0007267 ! cell-cell signaling intersection_of: GO:0007267 ! cell-cell signaling intersection_of: BFO:0000050 GO:0001890 ! part of placenta development relationship: BFO:0000050 GO:0001892 ! part of embryonic placenta development creation_date: 2009-06-02T12:58:03Z [Term] id: GO:0060674 name: placenta blood vessel development namespace: biological_process def: "The process whose specific outcome is the progression of a blood vessel of the placenta over time, from its formation to the mature structure." [GOC:dph, PMID:16916377] is_a: GO:0001568 ! blood vessel development relationship: BFO:0000050 GO:0001890 ! part of placenta development creation_date: 2009-06-02T01:09:43Z [Term] id: GO:0060675 name: ureteric bud morphogenesis namespace: biological_process def: "The process in which the ureteric bud is generated and organized." [GOC:dph, GOC:mtg_kidney_jan10] is_a: GO:0072171 ! mesonephric tubule morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0000084 ! results in morphogenesis of ureteric bud relationship: BFO:0000050 GO:0001657 ! part of ureteric bud development relationship: RO:0002298 UBERON:0000084 ! results in morphogenesis of ureteric bud creation_date: 2009-06-02T01:31:41Z [Term] id: GO:0060676 name: ureteric bud formation namespace: biological_process def: "The developmental process pertaining to the initial formation of the ureteric bud from the Wolffian duct. This process begins when the bud protrudes from the duct and ends when it is a recognizable bud." [GOC:dph, PMID:16916378] xref: Reactome:R-HSA-9830674 "Formation of the ureteric bud" is_a: GO:0072172 ! mesonephric tubule formation intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0000084 ! results in formation of anatomical entity ureteric bud relationship: BFO:0000050 GO:0060675 ! part of ureteric bud morphogenesis relationship: RO:0002297 UBERON:0000084 ! results in formation of anatomical entity ureteric bud creation_date: 2009-06-02T01:47:23Z [Term] id: GO:0060680 name: lateral sprouting involved in ureteric bud morphogenesis namespace: biological_process def: "The process in which a branch forms along the side of a ureteric bud." [GOC:dph, PMID:16916378] is_a: GO:0060601 ! lateral sprouting from an epithelium intersection_of: GO:0060601 ! lateral sprouting from an epithelium intersection_of: BFO:0000050 GO:0001658 ! part of branching involved in ureteric bud morphogenesis relationship: BFO:0000050 GO:0001658 ! part of branching involved in ureteric bud morphogenesis creation_date: 2009-06-02T02:44:27Z [Term] id: GO:0060684 name: epithelial-mesenchymal cell signaling namespace: biological_process def: "Any process that results in the transfer of information from an epithelial cell to a mesenchymal cell where it is interpreted." [GOC:dph] synonym: "epithelial-mesenchymal cell signalling" EXACT [GOC:mah] is_a: GO:0007267 ! cell-cell signaling intersection_of: GO:0007267 ! cell-cell signaling intersection_of: RO:0002231 CL:0000066 ! has start location epithelial cell intersection_of: RO:0002232 CL:0008019 ! has end location mesenchymal cell relationship: RO:0002231 CL:0000066 ! has start location epithelial cell relationship: RO:0002232 CL:0008019 ! has end location mesenchymal cell creation_date: 2009-06-03T06:36:46Z [Term] id: GO:0060685 name: regulation of prostatic bud formation namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of prostatic bud formation, the morphogenetic process in which a region of the fetal urogenital sinus epithelium is specified to become the prostate, resulting in prostate bud outgrowth." [GOC:dph] is_a: GO:0003156 ! regulation of animal organ formation is_a: GO:0060688 ! regulation of morphogenesis of a branching structure is_a: GO:1905330 ! regulation of morphogenesis of an epithelium is_a: GO:2000241 ! regulation of reproductive process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0060513 ! regulates prostatic bud formation relationship: RO:0002211 GO:0060513 ! regulates prostatic bud formation creation_date: 2009-06-05T12:29:26Z [Term] id: GO:0060686 name: negative regulation of prostatic bud formation namespace: biological_process def: "Any process that decreases the rate, frequency, or extent of prostatic bud formation, the morphogenetic process in which a region of the fetal urogenital sinus epithelium is specified to become the prostate, resulting in prostate bud outgrowth." [GOC:dph] is_a: GO:0060685 ! regulation of prostatic bud formation is_a: GO:1905331 ! negative regulation of morphogenesis of an epithelium is_a: GO:2000242 ! negative regulation of reproductive process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0060513 ! negatively regulates prostatic bud formation relationship: RO:0002212 GO:0060513 ! negatively regulates prostatic bud formation creation_date: 2009-06-05T12:35:25Z [Term] id: GO:0060687 name: regulation of branching involved in prostate gland morphogenesis namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of prostate gland branching, the process in which the branching structure of the prostate gland is generated and organized. A branch is a division or offshoot from a main stem." [GOC:dph] is_a: GO:0060688 ! regulation of morphogenesis of a branching structure is_a: GO:1905330 ! regulation of morphogenesis of an epithelium is_a: GO:2000241 ! regulation of reproductive process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0060442 ! regulates branching involved in prostate gland morphogenesis relationship: RO:0002211 GO:0060442 ! regulates branching involved in prostate gland morphogenesis creation_date: 2009-06-05T12:37:14Z [Term] id: GO:0060688 name: regulation of morphogenesis of a branching structure namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of branching morphogenesis, the process in which the anatomical structures of branches are generated and organized." [GOC:dph] is_a: GO:0022603 ! regulation of anatomical structure morphogenesis is_a: GO:0051239 ! regulation of multicellular organismal process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0001763 ! regulates morphogenesis of a branching structure relationship: RO:0002211 GO:0001763 ! regulates morphogenesis of a branching structure property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 creation_date: 2009-06-05T12:41:44Z [Term] id: GO:0060689 name: cell differentiation involved in salivary gland development namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized structural and/or functional features that characterize the cells of the salivary gland." [GOC:dph] is_a: GO:0030154 ! cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: BFO:0000050 GO:0007431 ! part of salivary gland development relationship: BFO:0000050 GO:0007431 ! part of salivary gland development creation_date: 2009-06-08T01:01:35Z [Term] id: GO:0060690 name: epithelial cell differentiation involved in salivary gland development namespace: biological_process def: "The process in which a relatively unspecialized cell acquire specialized structural and/or functional features of an epithelial cell of the salivary gland." [GOC:dph] is_a: GO:0030855 ! epithelial cell differentiation is_a: GO:0060689 ! cell differentiation involved in salivary gland development intersection_of: GO:0030855 ! epithelial cell differentiation intersection_of: BFO:0000050 GO:0007431 ! part of salivary gland development creation_date: 2009-06-08T01:04:19Z [Term] id: GO:0060691 name: epithelial cell maturation involved in salivary gland development namespace: biological_process def: "The developmental process, independent of morphogenetic (shape) change, that is required for an epithelial cell of the salivary gland to attain its fully functional state." [GOC:dph] is_a: GO:0002070 ! epithelial cell maturation intersection_of: GO:0002070 ! epithelial cell maturation intersection_of: BFO:0000050 GO:0007431 ! part of salivary gland development relationship: BFO:0000050 GO:0060690 ! part of epithelial cell differentiation involved in salivary gland development creation_date: 2009-06-08T01:06:00Z [Term] id: GO:0060692 name: mesenchymal cell differentiation involved in salivary gland development namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a mesenchymal cell of the salivary gland. A mesenchymal cell is a loosely associated cell that is part of the connective tissue in an organism. Mesenchymal cells give rise to more mature connective tissue cell types." [GOC:dph] is_a: GO:0048762 ! mesenchymal cell differentiation is_a: GO:0060689 ! cell differentiation involved in salivary gland development intersection_of: GO:0048762 ! mesenchymal cell differentiation intersection_of: BFO:0000050 GO:0007431 ! part of salivary gland development creation_date: 2009-06-08T01:08:44Z [Term] id: GO:0060693 name: regulation of branching involved in salivary gland morphogenesis namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of branching morphogenesis in the salivary gland epithelium." [GOC:dph] is_a: GO:0060688 ! regulation of morphogenesis of a branching structure is_a: GO:1905330 ! regulation of morphogenesis of an epithelium is_a: GO:2000027 ! regulation of animal organ morphogenesis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0060445 ! regulates branching involved in salivary gland morphogenesis relationship: RO:0002211 GO:0060445 ! regulates branching involved in salivary gland morphogenesis creation_date: 2009-06-08T01:14:44Z [Term] id: GO:0060704 name: acinar cell differentiation involved in salivary gland development namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized structural and/or functional features that characterize an acinar cell of the salivary gland. Acinar cells are protein-secreting cells in the gland." [GOC:dph, GOC:tb] is_a: GO:0060690 ! epithelial cell differentiation involved in salivary gland development is_a: GO:0090425 ! acinar cell differentiation intersection_of: GO:0090425 ! acinar cell differentiation intersection_of: BFO:0000050 GO:0007431 ! part of salivary gland development creation_date: 2009-06-09T09:32:46Z [Term] id: GO:0060705 name: neuron differentiation involved in salivary gland development namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized structural and/or functional features that characterize the neurons of the salivary gland." [GOC:dph] is_a: GO:0030182 ! neuron differentiation is_a: GO:0060689 ! cell differentiation involved in salivary gland development intersection_of: GO:0030182 ! neuron differentiation intersection_of: BFO:0000050 GO:0007431 ! part of salivary gland development creation_date: 2009-06-09T09:35:52Z [Term] id: GO:0060706 name: cell differentiation involved in embryonic placenta development namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of the embryonic placenta." [GOC:dph] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0030154 ! cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: BFO:0000050 GO:0001892 ! part of embryonic placenta development relationship: BFO:0000050 GO:0001892 ! part of embryonic placenta development creation_date: 2009-06-09T10:26:42Z [Term] id: GO:0060707 name: trophoblast giant cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a trophoblast giant cell of the placenta. Trophoblast giant cells are the cell of the placenta that line the maternal decidua." [GOC:dph, PMID:16269175] is_a: GO:0060706 ! cell differentiation involved in embryonic placenta development intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0002488 ! results in acquisition of features of trophoblast giant cell relationship: RO:0002315 CL:0002488 ! results in acquisition of features of trophoblast giant cell creation_date: 2009-06-09T10:32:12Z [Term] id: GO:0060708 name: spongiotrophoblast differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell of the ectoplacental cone acquires specialized features of a spongiotrophoblast of the placenta. A spongiotrophoblast cell is a basophilic cell." [GOC:dph, PMID:16269175] synonym: "spongiotrophoblast cell differentiation" EXACT [GOC:cjm] is_a: GO:0060706 ! cell differentiation involved in embryonic placenta development intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0002499 ! results in acquisition of features of spongiotrophoblast cell relationship: BFO:0000050 GO:0060712 ! part of spongiotrophoblast layer development relationship: RO:0002315 CL:0002499 ! results in acquisition of features of spongiotrophoblast cell creation_date: 2009-06-09T10:38:10Z [Term] id: GO:0060711 name: labyrinthine layer development namespace: biological_process def: "The process in which the labyrinthine layer of the placenta progresses, from its formation to its mature state." [GOC:dph] is_a: GO:0048856 ! anatomical structure development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0003946 ! results in development of placenta labyrinth relationship: BFO:0000050 GO:0001892 ! part of embryonic placenta development relationship: RO:0002296 UBERON:0003946 ! results in development of placenta labyrinth creation_date: 2009-06-09T03:27:43Z [Term] id: GO:0060712 name: spongiotrophoblast layer development namespace: biological_process def: "The process in which the spongiotrophoblast layer of the placenta progresses from its formation to its mature state." [GOC:dph] is_a: GO:0009888 ! tissue development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0004021 ! results in development of spongiotrophoblast layer relationship: BFO:0000050 GO:0001892 ! part of embryonic placenta development relationship: RO:0002162 NCBITaxon:9989 ! in taxon Rodentia relationship: RO:0002296 UBERON:0004021 ! results in development of spongiotrophoblast layer creation_date: 2009-06-09T03:33:40Z [Term] id: GO:0060713 name: labyrinthine layer morphogenesis namespace: biological_process def: "The process in which the labyrinthine layer of the placenta is generated and organized." [GOC:dph] is_a: BFO:0000003 is_a: GO:0048598 ! embryonic morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0003946 ! results in morphogenesis of placenta labyrinth relationship: BFO:0000050 GO:0060669 ! part of embryonic placenta morphogenesis relationship: BFO:0000050 GO:0060711 ! part of labyrinthine layer development relationship: RO:0002298 UBERON:0003946 ! results in morphogenesis of placenta labyrinth creation_date: 2009-06-10T08:10:19Z [Term] id: GO:0060714 name: labyrinthine layer formation namespace: biological_process def: "The developmental process pertaining to the initial formation of the labyrinthine layer of the placenta." [GOC:dph] is_a: BFO:0000003 is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0003946 ! results in formation of anatomical entity placenta labyrinth relationship: BFO:0000050 GO:0060713 ! part of labyrinthine layer morphogenesis relationship: RO:0002297 UBERON:0003946 ! results in formation of anatomical entity placenta labyrinth creation_date: 2009-06-10T08:13:14Z [Term] id: GO:0060716 name: labyrinthine layer blood vessel development namespace: biological_process def: "The process whose specific outcome is the progression of a blood vessel of the labyrinthine layer of the placenta over time, from its formation to the mature structure. The embryonic vessels grow through the layer to come in close contact with the maternal blood supply." [GOC:dph] is_a: GO:0048568 ! embryonic organ development is_a: GO:0060674 ! placenta blood vessel development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0004183 ! results in development of placental labyrinth blood vessel relationship: BFO:0000050 GO:0060711 ! part of labyrinthine layer development relationship: RO:0002296 UBERON:0004183 ! results in development of placental labyrinth blood vessel creation_date: 2009-06-11T09:04:38Z [Term] id: GO:0060717 name: chorion development namespace: biological_process def: "The biological process whose specific outcome is the progression of a chorion from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure. The chorion is an extraembryonic membrane." [GOC:dph] is_a: GO:1903867 ! extraembryonic membrane development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0003124 ! results in development of chorion membrane relationship: RO:0002162 NCBITaxon:32525 ! in taxon Theria relationship: RO:0002296 UBERON:0003124 ! results in development of chorion membrane creation_date: 2009-06-11T02:37:50Z [Term] id: GO:0060718 name: chorionic trophoblast cell differentiation namespace: biological_process def: "The process in which relatively unspecialized cells of the ectoplacental cone acquire specialized structural and/or functional features that characterize chorionic trophoblasts. These cells will migrate towards the spongiotrophoblast layer and give rise to syncytiotrophoblasts of the labyrinthine layer." [CL:0011101, GOC:dph, PMID:16983341] is_a: GO:0030154 ! cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0011101 ! results in acquisition of features of chorionic trophoblast cell relationship: BFO:0000050 GO:0060717 ! part of chorion development relationship: RO:0002315 CL:0011101 ! results in acquisition of features of chorionic trophoblast cell creation_date: 2009-06-11T02:48:27Z [Term] id: GO:0060719 name: chorionic trophoblast cell development namespace: biological_process def: "The process whose specific outcome is the progression of the chorionic trophoblast over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate." [CL:0011101, GOC:16983341, GOC:dph] is_a: GO:0048468 ! cell development intersection_of: GO:0048468 ! cell development intersection_of: RO:0002296 CL:0011101 ! results in development of chorionic trophoblast cell relationship: BFO:0000050 GO:0060718 ! part of chorionic trophoblast cell differentiation relationship: RO:0002296 CL:0011101 ! results in development of chorionic trophoblast cell creation_date: 2009-06-11T02:58:45Z [Term] id: GO:0060722 name: cell proliferation involved in embryonic placenta development namespace: biological_process def: "The multiplication or reproduction of cells, resulting in the expansion of the population in the embryonic placenta." [GOC:dph] is_a: GO:0008283 ! cell population proliferation intersection_of: GO:0008283 ! cell population proliferation intersection_of: BFO:0000050 GO:0001892 ! part of embryonic placenta development relationship: BFO:0000050 GO:0001892 ! part of embryonic placenta development creation_date: 2009-06-12T12:46:04Z [Term] id: GO:0060723 name: regulation of cell proliferation involved in embryonic placenta development namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of cell proliferation involved in embryonic placenta development." [GOC:dph] is_a: GO:0042127 ! regulation of cell population proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0060722 ! regulates cell proliferation involved in embryonic placenta development relationship: RO:0002211 GO:0060722 ! regulates cell proliferation involved in embryonic placenta development creation_date: 2009-06-12T12:50:23Z [Term] id: GO:0060736 name: prostate gland growth namespace: biological_process def: "The increase in size or mass of the prostate gland where the increase in size or mass has the specific outcome of the progression of the gland, from its formation to its mature state." [GOC:dph] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0035265 ! organ growth intersection_of: GO:0048589 ! developmental growth intersection_of: RO:0002343 UBERON:0002367 ! results in growth of prostate gland relationship: BFO:0000050 GO:0030850 ! part of prostate gland development relationship: RO:0002343 UBERON:0002367 ! results in growth of prostate gland creation_date: 2009-06-15T09:21:52Z [Term] id: GO:0060737 name: prostate gland morphogenetic growth namespace: biological_process def: "The differential increase in size or mass of the prostate gland that contributes to the gland attaining its form." [GOC:dph] synonym: "prostate gland growth involved in morphogenesis" EXACT [GOC:dph] is_a: GO:0060560 ! developmental growth involved in morphogenesis is_a: GO:0060736 ! prostate gland growth intersection_of: GO:0060736 ! prostate gland growth intersection_of: BFO:0000050 GO:0009653 ! part of anatomical structure morphogenesis relationship: BFO:0000050 GO:0060512 ! part of prostate gland morphogenesis creation_date: 2009-06-15T09:24:40Z [Term] id: GO:0060738 name: epithelial-mesenchymal signaling involved in prostate gland development namespace: biological_process def: "Any process that results in the transfer of information from an epithelial cell to a mesenchymal cell where it is interpreted and contributes to the progression of the prostate gland over time." [GOC:dph] synonym: "epithelial-mesenchymal signalling involved in prostate gland development" EXACT [GOC:mah] is_a: GO:0060684 ! epithelial-mesenchymal cell signaling intersection_of: GO:0060684 ! epithelial-mesenchymal cell signaling intersection_of: BFO:0000050 GO:0030850 ! part of prostate gland development relationship: BFO:0000050 GO:0030850 ! part of prostate gland development creation_date: 2009-06-15T09:31:31Z [Term] id: GO:0060739 name: mesenchymal-epithelial cell signaling involved in prostate gland development namespace: biological_process def: "Any process that mediates the transfer of information from a mesenchymal cell to an epithelial cell where it is received and interpreted contributing to the progression of the prostate gland over time." [GOC:dph] synonym: "mesenchymal-epithelial cell signalling involved in prostate gland development" EXACT [GOC:mah] is_a: GO:0060638 ! mesenchymal-epithelial cell signaling intersection_of: GO:0060638 ! mesenchymal-epithelial cell signaling intersection_of: BFO:0000050 GO:0030850 ! part of prostate gland development relationship: BFO:0000050 GO:0030850 ! part of prostate gland development creation_date: 2009-06-15T09:35:08Z [Term] id: GO:0060740 name: prostate gland epithelium morphogenesis namespace: biological_process def: "The process in which the anatomical structures of epithelia of the prostate gland are generated and organized. An epithelium consists of closely packed cells arranged in one or more layers, that covers the outer surfaces of the body or lines any internal cavity or tube." [GOC:dph] is_a: GO:0002009 ! morphogenesis of an epithelium is_a: GO:0003006 ! developmental process involved in reproduction intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0000428 ! results in morphogenesis of prostate epithelium relationship: BFO:0000050 GO:0060512 ! part of prostate gland morphogenesis relationship: RO:0002298 UBERON:0000428 ! results in morphogenesis of prostate epithelium creation_date: 2009-06-16T09:23:22Z [Term] id: GO:0060741 name: prostate gland stromal morphogenesis namespace: biological_process def: "The process in which the prostate gland stroma is generated and organized. The prostate gland stroma is made up of the mesenchymal or fibroblast cells of the prostate gland." [GOC:dph] is_a: BFO:0000003 is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0009653 ! anatomical structure morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0004184 ! results in morphogenesis of prostate gland stroma relationship: BFO:0000050 GO:0060512 ! part of prostate gland morphogenesis relationship: BFO:0000050 GO:0061448 ! part of connective tissue development relationship: RO:0002298 UBERON:0004184 ! results in morphogenesis of prostate gland stroma creation_date: 2009-06-16T09:27:01Z [Term] id: GO:0060742 name: epithelial cell differentiation involved in prostate gland development namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of an epithelial cell of the prostate gland." [GOC:dph] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0030855 ! epithelial cell differentiation intersection_of: GO:0030855 ! epithelial cell differentiation intersection_of: BFO:0000050 GO:0030850 ! part of prostate gland development relationship: BFO:0000050 GO:0030850 ! part of prostate gland development creation_date: 2009-06-16T09:32:34Z [Term] id: GO:0060743 name: epithelial cell maturation involved in prostate gland development namespace: biological_process def: "The developmental process, independent of morphogenetic (shape) change, that is required for an epithelial cell of the prostate gland to attain its fully functional state. An epithelial cell is a cell usually found in a two-dimensional sheet with a free surface." [GOC:dph] synonym: "prostate gland epithelial cell development" EXACT [GOC:dph] is_a: GO:0002070 ! epithelial cell maturation intersection_of: GO:0002070 ! epithelial cell maturation intersection_of: BFO:0000050 GO:0030850 ! part of prostate gland development relationship: BFO:0000050 GO:0060742 ! part of epithelial cell differentiation involved in prostate gland development creation_date: 2009-06-16T09:34:42Z [Term] id: GO:0060749 name: mammary gland alveolus development namespace: biological_process def: "The progression of the mammary gland alveolus over time, from its formation to its mature state. The mammary gland alveolus is a sac-like structure that is found in the mature gland." [GOC:dph] is_a: GO:0048856 ! anatomical structure development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0003214 ! results in development of mammary gland alveolus relationship: BFO:0000050 GO:0061377 ! part of mammary gland lobule development relationship: RO:0002296 UBERON:0003214 ! results in development of mammary gland alveolus creation_date: 2009-06-22T10:52:12Z [Term] id: GO:0060753 name: regulation of mast cell chemotaxis namespace: biological_process def: "Any process that modulates the rate, frequency or extent of mast cell chemotaxis. Mast cell chemotaxis is the movement of a mast cell in response to an external stimulus." [GOC:dph, GOC:tb] is_a: GO:0002688 ! regulation of leukocyte chemotaxis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0002551 ! regulates mast cell chemotaxis relationship: RO:0002211 GO:0002551 ! regulates mast cell chemotaxis creation_date: 2009-06-22T02:36:06Z [Term] id: GO:0060754 name: positive regulation of mast cell chemotaxis namespace: biological_process def: "Any process that increases the rate, frequency or extent of mast cell chemotaxis. Mast cell chemotaxis is the movement of a mast cell in response to an external stimulus." [GOC:dph, GOC:tb] is_a: GO:0002690 ! positive regulation of leukocyte chemotaxis is_a: GO:0060753 ! regulation of mast cell chemotaxis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0002551 ! positively regulates mast cell chemotaxis relationship: RO:0002213 GO:0002551 ! positively regulates mast cell chemotaxis creation_date: 2009-06-22T02:38:19Z [Term] id: GO:0060755 name: negative regulation of mast cell chemotaxis namespace: biological_process def: "Any process that decreases the rate, frequency or extent of mast cell chemotaxis. Mast cell chemotaxis is the movement of a mast cell in response to an external stimulus." [GOC:dph, GOC:tb] is_a: GO:0002689 ! negative regulation of leukocyte chemotaxis is_a: GO:0060753 ! regulation of mast cell chemotaxis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0002551 ! negatively regulates mast cell chemotaxis relationship: RO:0002212 GO:0002551 ! negatively regulates mast cell chemotaxis creation_date: 2009-06-22T02:40:58Z [Term] id: GO:0060759 name: regulation of response to cytokine stimulus namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of a response to cytokine stimulus." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0048583 ! regulation of response to stimulus intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0034097 ! regulates response to cytokine relationship: RO:0002211 GO:0034097 ! regulates response to cytokine creation_date: 2009-06-22T02:56:12Z [Term] id: GO:0060760 name: positive regulation of response to cytokine stimulus namespace: biological_process def: "Any process that increases the rate, frequency, or extent of a response to cytokine stimulus." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0048584 ! positive regulation of response to stimulus is_a: GO:0060759 ! regulation of response to cytokine stimulus intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0034097 ! positively regulates response to cytokine relationship: RO:0002213 GO:0034097 ! positively regulates response to cytokine creation_date: 2009-06-22T02:58:04Z [Term] id: GO:0060761 name: negative regulation of response to cytokine stimulus namespace: biological_process def: "Any process that decreases the rate, frequency, or extent of a response to cytokine stimulus." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0048585 ! negative regulation of response to stimulus is_a: GO:0060759 ! regulation of response to cytokine stimulus intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0034097 ! negatively regulates response to cytokine relationship: RO:0002212 GO:0034097 ! negatively regulates response to cytokine creation_date: 2009-06-22T02:59:57Z [Term] id: GO:0060762 name: regulation of branching involved in mammary gland duct morphogenesis namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of branching involved in mammary gland duct morphogenesis." [GOC:dph] is_a: GO:0060688 ! regulation of morphogenesis of a branching structure is_a: GO:1905330 ! regulation of morphogenesis of an epithelium is_a: GO:2000027 ! regulation of animal organ morphogenesis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0060444 ! regulates branching involved in mammary gland duct morphogenesis relationship: RO:0002211 GO:0060444 ! regulates branching involved in mammary gland duct morphogenesis creation_date: 2009-06-22T05:20:33Z [Term] id: GO:0060764 name: cell-cell signaling involved in mammary gland development namespace: biological_process def: "Any process that mediates the transfer of information from one cell to another and contributes to the progression of the mammary gland, from its initial state to the mature structure." [GOC:dph] synonym: "cell-cell signalling involved in mammary gland development" EXACT [GOC:mah] is_a: GO:0007267 ! cell-cell signaling intersection_of: GO:0007267 ! cell-cell signaling intersection_of: BFO:0000050 GO:0030879 ! part of mammary gland development relationship: BFO:0000050 GO:0030879 ! part of mammary gland development creation_date: 2009-07-06T09:24:53Z [Term] id: GO:0060767 name: epithelial cell proliferation involved in prostate gland development namespace: biological_process def: "The multiplication or reproduction of epithelial cells, resulting in the expansion of a cell population that contributes to the progression of the prostate gland over time." [GOC:dph] is_a: GO:0050673 ! epithelial cell proliferation intersection_of: GO:0050673 ! epithelial cell proliferation intersection_of: BFO:0000050 GO:0030850 ! part of prostate gland development relationship: BFO:0000050 GO:0030850 ! part of prostate gland development creation_date: 2009-07-08T07:32:34Z [Term] id: GO:0060768 name: regulation of epithelial cell proliferation involved in prostate gland development namespace: biological_process def: "Any process that modulates the rate, frequency or extent of epithelial cell proliferation that contributes to the progression of the prostate gland over time." [GOC:dph] is_a: GO:0050678 ! regulation of epithelial cell proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0060767 ! regulates epithelial cell proliferation involved in prostate gland development relationship: RO:0002211 GO:0060767 ! regulates epithelial cell proliferation involved in prostate gland development creation_date: 2009-07-08T07:34:56Z [Term] id: GO:0060769 name: positive regulation of epithelial cell proliferation involved in prostate gland development namespace: biological_process def: "Any process that increases the rate, frequency or extent of epithelial cell proliferation that contributes to the progression of the prostate gland over time." [GOC:dph] is_a: GO:0050679 ! positive regulation of epithelial cell proliferation is_a: GO:0051094 ! positive regulation of developmental process is_a: GO:0060768 ! regulation of epithelial cell proliferation involved in prostate gland development is_a: GO:2000243 ! positive regulation of reproductive process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0060767 ! positively regulates epithelial cell proliferation involved in prostate gland development relationship: RO:0002213 GO:0060767 ! positively regulates epithelial cell proliferation involved in prostate gland development creation_date: 2009-07-08T07:38:02Z [Term] id: GO:0060770 name: negative regulation of epithelial cell proliferation involved in prostate gland development namespace: biological_process def: "Any process that decreases the rate, frequency or extent of epithelial cell proliferation that contributes to the progression of the prostate gland over time." [GOC:dph] is_a: GO:0050680 ! negative regulation of epithelial cell proliferation is_a: GO:0051093 ! negative regulation of developmental process is_a: GO:0051241 ! negative regulation of multicellular organismal process is_a: GO:0060768 ! regulation of epithelial cell proliferation involved in prostate gland development is_a: GO:2000242 ! negative regulation of reproductive process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0060767 ! negatively regulates epithelial cell proliferation involved in prostate gland development relationship: RO:0002212 GO:0060767 ! negatively regulates epithelial cell proliferation involved in prostate gland development creation_date: 2009-07-08T07:40:27Z [Term] id: GO:0060781 name: mesenchymal cell proliferation involved in prostate gland development namespace: biological_process def: "The multiplication or reproduction of mesenchymal cells, resulting in the expansion of a cell population that contributes to the progression of the prostate gland over time." [GOC:dph, PMID:12221011] is_a: GO:0010463 ! mesenchymal cell proliferation intersection_of: GO:0010463 ! mesenchymal cell proliferation intersection_of: BFO:0000050 GO:0030850 ! part of prostate gland development relationship: BFO:0000050 GO:0030850 ! part of prostate gland development creation_date: 2009-07-28T11:50:56Z [Term] id: GO:0060782 name: regulation of mesenchymal cell proliferation involved in prostate gland development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of mesenchymal cell proliferation that contributes to the progression of the prostate gland over time. A mesenchymal cell is a cell that normally gives rise to other cells that are organized as three-dimensional masses, rather than sheets." [GOC:dph, PMID:12221011] is_a: GO:0010464 ! regulation of mesenchymal cell proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0060781 ! regulates mesenchymal cell proliferation involved in prostate gland development relationship: RO:0002211 GO:0060781 ! regulates mesenchymal cell proliferation involved in prostate gland development creation_date: 2009-07-28T11:54:20Z [Term] id: GO:0060784 name: regulation of cell proliferation involved in tissue homeostasis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cell proliferation resulting in the maintenance of a steady-state number of cells within a tissue." [GOC:dph] is_a: GO:0042127 ! regulation of cell population proliferation intersection_of: GO:0042127 ! regulation of cell population proliferation intersection_of: BFO:0000050 GO:0001894 ! part of tissue homeostasis relationship: BFO:0000050 GO:0048873 ! part of homeostasis of number of cells within a tissue property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4751 creation_date: 2009-07-31T01:46:28Z [Term] id: GO:0060785 name: regulation of apoptosis involved in tissue homeostasis namespace: biological_process def: "Any process that modulates the occurrence or rate of cell death by apoptosis that results in the maintenance of the steady-state number of cells within a tissue." [GOC:dph] is_a: GO:0042981 ! regulation of apoptotic process intersection_of: GO:0042981 ! regulation of apoptotic process intersection_of: BFO:0000050 GO:0001894 ! part of tissue homeostasis relationship: BFO:0000050 GO:0048873 ! part of homeostasis of number of cells within a tissue property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 creation_date: 2009-07-31T01:49:54Z [Term] id: GO:0060786 name: regulation of cell differentiation involved in tissue homeostasis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cell differentiation that contributes to the maintenance of a steady state of a cell type within a tissue." [GOC:dph] is_a: GO:0045595 ! regulation of cell differentiation intersection_of: GO:0045595 ! regulation of cell differentiation intersection_of: BFO:0000050 GO:0001894 ! part of tissue homeostasis relationship: BFO:0000050 GO:0048873 ! part of homeostasis of number of cells within a tissue property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 creation_date: 2009-07-31T01:55:19Z [Term] id: GO:0060788 name: ectodermal placode formation namespace: biological_process def: "The developmental process in which an ectodermal placode forms. An ectodermal placode is a thickening of the ectoderm that is the primordium of many structures derived from the ectoderm." [GOC:dph, GOC:sdb_2009, GOC:tb] is_a: BFO:0000003 is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0005085 ! results in formation of anatomical entity ectodermal placode relationship: BFO:0000050 GO:0071697 ! part of ectodermal placode morphogenesis relationship: RO:0002297 UBERON:0005085 ! results in formation of anatomical entity ectodermal placode creation_date: 2009-08-04T12:15:57Z [Term] id: GO:0060789 name: hair follicle placode formation namespace: biological_process def: "The developmental process in which a hair placode forms. An hair follicle placode is a thickening of the ectoderm that will give rise to the hair follicle bud." [GOC:dph, GOC:sdb_2009, GOC:tb] is_a: GO:0060788 ! ectodermal placode formation intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0005086 ! results in formation of anatomical entity hair follicle placode relationship: BFO:0000050 GO:0001942 ! part of hair follicle development relationship: RO:0002297 UBERON:0005086 ! results in formation of anatomical entity hair follicle placode creation_date: 2009-08-04T12:18:26Z [Term] id: GO:0060790 name: tooth placode formation namespace: biological_process def: "The developmental process in which the tooth placode forms. A tooth placode is a thickening of the ectoderm that will give rise to the tooth bud." [GOC:dph, GOC:sdb_2009, GOC:tb] is_a: GO:0060788 ! ectodermal placode formation intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0005087 ! results in formation of anatomical entity tooth placode relationship: BFO:0000050 GO:0042475 ! part of odontogenesis of dentin-containing tooth relationship: RO:0002297 UBERON:0005087 ! results in formation of anatomical entity tooth placode property_value: RO:0002161 NCBITaxon:8782 creation_date: 2009-08-04T12:21:47Z [Term] id: GO:0060791 name: sebaceous gland placode formation namespace: biological_process def: "The developmental process in which a sebaceous gland placode forms. A sebaceous gland placode is a thickening of the ectoderm that will give rise to the sebaceous gland bud." [GOC:dph, GOC:sdb_2009, GOC:tb] is_a: GO:0060788 ! ectodermal placode formation intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0005088 ! results in formation of anatomical entity sebaceous gland placode relationship: BFO:0000050 GO:0048733 ! part of sebaceous gland development relationship: RO:0002297 UBERON:0005088 ! results in formation of anatomical entity sebaceous gland placode creation_date: 2009-08-04T12:23:09Z [Term] id: GO:0060792 name: sweat gland development namespace: biological_process def: "The progression of the sweat gland over time, from its formation to the mature structure. Sweat glands secrete an aqueous solution that is used in thermoregulation." [GOC:dph, GOC:sdb_2009, GOC:tb] is_a: GO:0048732 ! gland development intersection_of: GO:0048732 ! gland development intersection_of: RO:0002296 UBERON:0001820 ! results in development of sweat gland relationship: RO:0002162 NCBITaxon:40674 ! in taxon Mammalia relationship: RO:0002296 UBERON:0001820 ! results in development of sweat gland creation_date: 2009-08-04T12:35:12Z [Term] id: GO:0060793 name: sweat gland placode formation namespace: biological_process def: "The developmental process in which the sweat gland placode forms. An sweat gland placode is a thickening of the ectoderm that will give rise to the sweat gland bud." [GOC:dph, GOC:sdb_2009, GOC:tb] is_a: GO:0060788 ! ectodermal placode formation intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0005089 ! results in formation of anatomical entity sweat gland placode relationship: BFO:0000050 GO:0060792 ! part of sweat gland development relationship: RO:0002297 UBERON:0005089 ! results in formation of anatomical entity sweat gland placode creation_date: 2009-08-04T12:38:10Z [Term] id: GO:0060795 name: cell fate commitment involved in formation of primary germ layer namespace: biological_process def: "The commitment of cells to specific cell fates of the endoderm, ectoderm, or mesoderm as a part of gastrulation." [GOC:dph, GOC:sdb_2009, GOC:tb] is_a: GO:0045165 ! cell fate commitment intersection_of: GO:0045165 ! cell fate commitment intersection_of: BFO:0000050 GO:0001704 ! part of formation of primary germ layer relationship: BFO:0000050 GO:0001704 ! part of formation of primary germ layer creation_date: 2009-08-04T03:11:22Z [Term] id: GO:0060800 name: regulation of cell differentiation involved in embryonic placenta development namespace: biological_process def: "Any process that modulates the rate, frequency or extent of cell differentiation that contributes to the progression of the placenta over time, from its initial condition to its mature state." [GOC:dph, GOC:sdb_2009, GOC:tb] is_a: GO:0045595 ! regulation of cell differentiation is_a: GO:2000241 ! regulation of reproductive process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0060706 ! regulates cell differentiation involved in embryonic placenta development relationship: RO:0002211 GO:0060706 ! regulates cell differentiation involved in embryonic placenta development creation_date: 2009-08-06T01:20:25Z [Term] id: GO:0060806 name: negative regulation of cell differentiation involved in embryonic placenta development namespace: biological_process def: "Any process that decreases the rate, frequency or extent of cell differentiation that contributes to the progression of the placenta over time, from its initial condition to its mature state." [GOC:dph, GOC:sdb_2009, GOC:tb] is_a: GO:0045596 ! negative regulation of cell differentiation is_a: GO:0060800 ! regulation of cell differentiation involved in embryonic placenta development is_a: GO:2000242 ! negative regulation of reproductive process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0060706 ! negatively regulates cell differentiation involved in embryonic placenta development relationship: RO:0002212 GO:0060706 ! negatively regulates cell differentiation involved in embryonic placenta development creation_date: 2009-08-06T02:02:18Z [Term] id: GO:0060815 name: regulation of translation involved in anterior/posterior axis specification namespace: biological_process def: "Any process that modulates the frequency, rate or extent of translation of mRNAs that contribute to the specification of the anterior/posterior axis." [GOC:dph, GOC:sdb_2009, GOC:tb] is_a: GO:0006417 ! regulation of translation intersection_of: GO:0006417 ! regulation of translation intersection_of: BFO:0000050 GO:0009948 ! part of anterior/posterior axis specification relationship: BFO:0000050 GO:0009948 ! part of anterior/posterior axis specification property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 creation_date: 2009-08-07T10:02:31Z [Term] id: GO:0060836 name: lymphatic endothelial cell differentiation namespace: biological_process def: "The process in which a venous blood vessel endothelial cell acquires specialized features of a lymphatic vessel endothelial cell, a thin flattened cell that lines the inside surfaces of lymph vessels." [GOC:dph, GOC:sdb_2009, GOC:tb] is_a: GO:0045446 ! endothelial cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0002138 ! results in acquisition of features of endothelial cell of lymphatic vessel relationship: BFO:0000050 GO:0001945 ! part of lymph vessel development relationship: RO:0002315 CL:0002138 ! results in acquisition of features of endothelial cell of lymphatic vessel creation_date: 2009-08-11T03:45:20Z [Term] id: GO:0060837 name: blood vessel endothelial cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a blood vessel endothelial cell, a thin flattened cell that lines the inside surfaces of blood vessels." [GOC:dph, GOC:sdb_2009, GOC:tb] is_a: GO:0045446 ! endothelial cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000071 ! results in acquisition of features of blood vessel endothelial cell relationship: BFO:0000050 GO:0001568 ! part of blood vessel development relationship: RO:0002315 CL:0000071 ! results in acquisition of features of blood vessel endothelial cell creation_date: 2009-08-11T03:47:36Z [Term] id: GO:0060840 name: artery development namespace: biological_process def: "The progression of the artery over time, from its initial formation to the mature structure. An artery is a blood vessel that carries blood away from the heart to a capillary bed." [GOC:dph, GOC:sdb_2009, GOC:tb] is_a: GO:0001568 ! blood vessel development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0001637 ! results in development of artery relationship: RO:0002296 UBERON:0001637 ! results in development of artery creation_date: 2009-08-12T10:10:51Z [Term] id: GO:0060841 name: venous blood vessel development namespace: biological_process def: "The progression of the venous blood vessel over time from its initial formation to the mature structure. Venous blood vessels carry blood back to the heart after the capillary bed." [GOC:dph, GOC:sdb_2009, GOC:tb] is_a: GO:0001568 ! blood vessel development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0001638 ! results in development of vein relationship: RO:0002296 UBERON:0001638 ! results in development of vein creation_date: 2009-08-12T10:14:07Z [Term] id: GO:0060842 name: arterial endothelial cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized endothelial cell acquires specialized features of an arterial endothelial cell, a thin flattened cell that lines the inside surfaces of arteries." [GOC:dph, GOC:sdb_2009, GOC:tb] is_a: GO:0060837 ! blood vessel endothelial cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:1000413 ! results in acquisition of features of endothelial cell of artery relationship: RO:0002315 CL:1000413 ! results in acquisition of features of endothelial cell of artery creation_date: 2009-08-12T10:41:34Z [Term] id: GO:0060843 name: venous endothelial cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized endothelial cell acquires specialized features of a venous endothelial cell, a thin flattened cell that lines the inside surfaces of veins." [GOC:dph, GOC:sdb_2009, GOC:tb] is_a: GO:0060837 ! blood vessel endothelial cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0002543 ! results in acquisition of features of vein endothelial cell relationship: RO:0002315 CL:0002543 ! results in acquisition of features of vein endothelial cell creation_date: 2009-08-12T10:43:40Z [Term] id: GO:0060854 name: branching involved in lymph vessel morphogenesis namespace: biological_process def: "The process of the coordinated growth and sprouting of lymph vessels giving rise to the organized lymphatic system." [GOC:dph, GOC:sdb_2009, GOC:tb] synonym: "patterning of lymph vessels" BROAD [GOC:dph] is_a: GO:0048754 ! branching morphogenesis of an epithelial tube intersection_of: GO:0048754 ! branching morphogenesis of an epithelial tube intersection_of: BFO:0000050 GO:0036303 ! part of lymph vessel morphogenesis relationship: BFO:0000050 GO:0001946 ! part of lymphangiogenesis creation_date: 2009-08-12T12:00:48Z [Term] id: GO:0060872 name: semicircular canal development namespace: biological_process def: "The progression of the semicircular canal from its initial formation to the mature structure." [GOC:dph, GOC:sdb_2009, GOC:tb] is_a: GO:0035295 ! tube development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0001840 ! results in development of semicircular canal relationship: BFO:0000050 GO:0048839 ! part of inner ear development relationship: RO:0002296 UBERON:0001840 ! results in development of semicircular canal creation_date: 2009-08-13T09:36:37Z [Term] id: GO:0060876 name: semicircular canal formation namespace: biological_process def: "The developmental process pertaining to the initial formation of the semicircular canal from the otic vesicle. This process begins with the regionalization of the vesicle that specifies the area where the vesicles will form and continues through the process of fusion which forms the initial tubes." [GOC:dph, GOC:sdb_2009, GOC:tb] is_a: GO:0035148 ! tube formation intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0001840 ! results in formation of anatomical entity semicircular canal relationship: BFO:0000050 GO:0048752 ! part of semicircular canal morphogenesis relationship: RO:0002297 UBERON:0001840 ! results in formation of anatomical entity semicircular canal creation_date: 2009-08-13T09:45:07Z [Term] id: GO:0060877 name: regionalization involved in semicircular canal formation namespace: biological_process def: "The pattern specification process that results in the subdivision of the otic epithelium in space to define an area or volume in which cells will differentiate to give rise to the semicircular canals." [GOC:dph, GOC:sdb_2009, GOC:tb] is_a: GO:0003002 ! regionalization intersection_of: GO:0003002 ! regionalization intersection_of: BFO:0000050 GO:0060876 ! part of semicircular canal formation relationship: BFO:0000050 GO:0060876 ! part of semicircular canal formation creation_date: 2009-08-13T09:56:45Z [Term] id: GO:0060878 name: pouch outgrowth involved in semicircular canal formation namespace: biological_process def: "The morphogenetic process in which an epithelial sheet bends along a linear axis and gives rise to a pouch that will form a semicircular canal." [GOC:dph, GOC:sdb_2009, GOC:tb] is_a: GO:0048598 ! embryonic morphogenesis is_a: GO:0060571 ! morphogenesis of an epithelial fold intersection_of: GO:0060571 ! morphogenesis of an epithelial fold intersection_of: BFO:0000050 GO:0060876 ! part of semicircular canal formation relationship: BFO:0000050 GO:0060876 ! part of semicircular canal formation creation_date: 2009-08-13T10:01:01Z [Term] id: GO:0060887 name: limb epidermis development namespace: biological_process def: "The process whose specific outcome is the progression of the epidermis of the limb over time, from its formation to the mature structure. The limb epidermis is the outer epithelial layer of the limb, it is a complex stratified squamous epithelium." [GOC:dph, GOC:sdb_2009, GOC:tb] is_a: GO:0098773 ! skin epidermis development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0009200 ! results in development of limb epidermis relationship: BFO:0000050 GO:0060173 ! part of limb development relationship: RO:0002162 NCBITaxon:32523 ! in taxon Tetrapoda relationship: RO:0002296 UBERON:0009200 ! results in development of limb epidermis creation_date: 2009-08-13T12:39:39Z [Term] id: GO:0060896 name: neural plate pattern specification namespace: biological_process def: "The developmental process that results in the creation of defined areas or spaces within the neural plate to which cells respond and eventually are instructed to differentiate." [GOC:dph, GOC:sdb_2009, GOC:tb] xref: Reactome:R-HSA-9834899 "Specification of the neural plate border" is_a: GO:0007389 ! pattern specification process property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 creation_date: 2009-08-13T02:06:27Z [Term] id: GO:0060897 name: neural plate regionalization namespace: biological_process def: "The pattern specification process that results in the subdivision of an axis or axes of the neural plate in space to define an area or volume in which specific patterns of cell differentiation will take place or in which cells interpret a specific environment." [GOC:dph, GOC:sdb_2009, GOC:tb] is_a: GO:0003002 ! regionalization is_a: GO:0060896 ! neural plate pattern specification property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 creation_date: 2009-08-13T02:09:04Z [Term] id: GO:0060900 name: embryonic camera-type eye formation namespace: biological_process def: "The developmental process pertaining to the initial formation of a camera-type eye from unspecified neurectoderm. This process begins with the differentiation of cells that form the optic field and ends when the optic cup has attained its shape." [GOC:dph, GOC:sdb_2009, GOC:tb] is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis relationship: BFO:0000050 GO:0048596 ! part of embryonic camera-type eye morphogenesis creation_date: 2009-08-13T02:26:54Z [Term] id: GO:0060907 name: positive regulation of macrophage cytokine production namespace: biological_process def: "Any process that increases the rate, frequency or extent of macrophage cytokine production. Macrophage cytokine production is the appearance of a chemokine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:dph, GOC:tb] is_a: GO:0010935 ! regulation of macrophage cytokine production is_a: GO:0061081 ! positive regulation of myeloid leukocyte cytokine production involved in immune response intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0010934 ! positively regulates macrophage cytokine production relationship: RO:0002213 GO:0010934 ! positively regulates macrophage cytokine production property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4895 property_value: RO:0002161 NCBITaxon:4932 creation_date: 2009-09-04T02:32:18Z [Term] id: GO:0060914 name: heart formation namespace: biological_process def: "The developmental process pertaining to the initial formation of the heart from unspecified parts. This process begins with the specific processes that contribute to the appearance of the heart field and the arrival of cardiac neural crest to the heart region. The process ends when the structural rudiment is recognizable." [GOC:mtg_heart] synonym: "cardiogenesis" RELATED [GOC:mtg_heart] xref: Reactome:R-HSA-9733709 "Cardiogenesis" is_a: GO:0048645 ! animal organ formation intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0000948 ! results in formation of anatomical entity heart relationship: BFO:0000050 GO:0003007 ! part of heart morphogenesis relationship: RO:0002297 UBERON:0000948 ! results in formation of anatomical entity heart creation_date: 2009-09-17T09:02:13Z [Term] id: GO:0060915 name: mesenchymal cell differentiation involved in lung development namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a mesenchymal cell of the lung. A mesenchymal cell is a loosely associated cell that is part of the connective tissue in an organism. Mesenchymal cells give rise to more mature connective tissue cell types." [GOC:dph] is_a: GO:0048762 ! mesenchymal cell differentiation intersection_of: GO:0048762 ! mesenchymal cell differentiation intersection_of: BFO:0000050 GO:0030324 ! part of lung development relationship: BFO:0000050 GO:0030324 ! part of lung development creation_date: 2009-09-18T11:45:33Z [Term] id: GO:0060916 name: mesenchymal cell proliferation involved in lung development namespace: biological_process def: "The multiplication or reproduction of cells, resulting in the expansion of a mesenchymal cell population that contributes to the progression of the lung over time. A mesenchymal cell is a cell that normally gives rise to other cells that are organized as three-dimensional masses, rather than sheets." [GOC:dph] is_a: GO:0010463 ! mesenchymal cell proliferation intersection_of: GO:0010463 ! mesenchymal cell proliferation intersection_of: BFO:0000050 GO:0030324 ! part of lung development relationship: BFO:0000050 GO:0030324 ! part of lung development creation_date: 2009-09-18T11:50:17Z [Term] id: GO:0060920 name: cardiac pacemaker cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a pacemaker cell. Pacemaker cells are specialized cardiomyocytes that are responsible for regulating the timing of heart contractions." [GOC:mtg_cardiac_conduct_nov11, GOC:mtg_heart] synonym: "pacemaker cell differentiation" BROAD [] is_a: GO:0055007 ! cardiac muscle cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0002072 ! results in acquisition of features of nodal myocyte relationship: RO:0002315 CL:0002072 ! results in acquisition of features of nodal myocyte creation_date: 2009-09-29T11:01:31Z [Term] id: GO:0060921 name: sinoatrial node cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a sinoatrial (SA) node cell. SA node cells are pacemaker cells that are found in the sinoatrial node." [GOC:mtg_heart] synonym: "SA node cell differentiation" EXACT [GOC:mtg_heart] synonym: "SAN cell differentiation" EXACT [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] synonym: "sinus node cell differentiation" NARROW [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] is_a: GO:0060920 ! cardiac pacemaker cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:1000409 ! results in acquisition of features of myocyte of sinoatrial node relationship: BFO:0000050 GO:0003163 ! part of sinoatrial node development relationship: RO:0002315 CL:1000409 ! results in acquisition of features of myocyte of sinoatrial node creation_date: 2009-09-29T11:03:30Z [Term] id: GO:0060922 name: atrioventricular node cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of an atrioventricular (AV) node cell. AV node cells are pacemaker cells that are found in the atrioventricular node." [GOC:mtg_heart] synonym: "AV node cell differentiation" RELATED [GOC:mtg_heart] is_a: GO:0003292 ! cardiac septum cell differentiation is_a: GO:0060920 ! cardiac pacemaker cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:1000410 ! results in acquisition of features of myocyte of atrioventricular node relationship: BFO:0000050 GO:0003162 ! part of atrioventricular node development relationship: RO:0002315 CL:1000410 ! results in acquisition of features of myocyte of atrioventricular node creation_date: 2009-09-29T11:07:06Z [Term] id: GO:0060926 name: cardiac pacemaker cell development namespace: biological_process def: "The process whose specific outcome is the progression of a pacemaker cell over time, from its formation to the mature state. Pacemaker cells are specialized cardiomyocytes that are responsible for regulating the timing of heart contractions." [GOC:mtg_cardiac_conduct_nov11, GOC:mtg_heart] synonym: "pacemaker cell development" BROAD [] is_a: GO:0055013 ! cardiac muscle cell development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 CL:0002072 ! results in development of nodal myocyte relationship: BFO:0000050 GO:0060920 ! part of cardiac pacemaker cell differentiation relationship: RO:0002296 CL:0002072 ! results in development of nodal myocyte creation_date: 2009-09-29T11:51:55Z [Term] id: GO:0060928 name: atrioventricular node cell development namespace: biological_process def: "The process whose specific outcome is the progression of an atrioventricular (AV) node cell over time, from its formation to the mature state." [GOC:mtg_heart] synonym: "AV node cell development" EXACT [GOC:mtg_heart] is_a: GO:0060926 ! cardiac pacemaker cell development intersection_of: GO:0048468 ! cell development intersection_of: RO:0002296 CL:1000410 ! results in development of myocyte of atrioventricular node relationship: BFO:0000050 GO:0060922 ! part of atrioventricular node cell differentiation relationship: RO:0002296 CL:1000410 ! results in development of myocyte of atrioventricular node creation_date: 2009-09-29T11:59:26Z [Term] id: GO:0060931 name: sinoatrial node cell development namespace: biological_process def: "The process whose specific outcome is the progression of a sinoatrial (SA) node cell over time, from its formation to the mature state. SA node cells are pacemaker cells that are found in the sinoatrial node." [GOC:mtg_heart] synonym: "SA node cell development" EXACT [GOC:mtg_heart] synonym: "SAN cell development" EXACT [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] synonym: "sinus node cell development" NARROW [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] is_a: GO:0060926 ! cardiac pacemaker cell development intersection_of: GO:0048468 ! cell development intersection_of: RO:0002296 CL:1000409 ! results in development of myocyte of sinoatrial node relationship: BFO:0000050 GO:0060921 ! part of sinoatrial node cell differentiation relationship: RO:0002296 CL:1000409 ! results in development of myocyte of sinoatrial node creation_date: 2009-09-29T12:05:47Z [Term] id: GO:0060932 name: His-Purkinje system cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of a cell of the His-Purkinje system. These cells form the fibers regulate cardiac muscle contraction in the ventricles." [GOC:mtg_heart] is_a: GO:0055007 ! cardiac muscle cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0010007 ! results in acquisition of features of His-Purkinje system cell relationship: BFO:0000050 GO:0003164 ! part of His-Purkinje system development relationship: RO:0002315 CL:0010007 ! results in acquisition of features of His-Purkinje system cell creation_date: 2009-09-29T01:10:32Z [Term] id: GO:0060933 name: His-Purkinje system cell development namespace: biological_process def: "The process whose specific outcome is the progression of a His-Purkinje cell over time, from its formation to the mature state. These cells form the fibers that regulate cardiac muscle contraction in the ventricles." [GOC:mtg_heart] is_a: GO:0055006 ! cardiac cell development intersection_of: GO:0048468 ! cell development intersection_of: RO:0002296 CL:0010007 ! results in development of His-Purkinje system cell relationship: BFO:0000050 GO:0060932 ! part of His-Purkinje system cell differentiation relationship: RO:0002296 CL:0010007 ! results in development of His-Purkinje system cell creation_date: 2009-09-29T01:15:02Z [Term] id: GO:0060935 name: cardiac fibroblast cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of a cardiac fibroblast. A cardiac fibroblast is a connective tissue cell in the heart which secretes an extracellular matrix rich in collagen and other macromolecules." [GOC:mtg_heart] is_a: GO:0035051 ! cardiocyte differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0002548 ! results in acquisition of features of fibroblast of cardiac tissue relationship: RO:0002315 CL:0002548 ! results in acquisition of features of fibroblast of cardiac tissue creation_date: 2009-09-29T01:20:04Z [Term] id: GO:0060936 name: cardiac fibroblast cell development namespace: biological_process def: "The process whose specific outcome is the progression of a cardiac fibroblast over time, from its formation to the mature state. A cardiac fibroblast is a connective tissue cell of the heart which secretes an extracellular matrix rich in collagen and other macromolecules." [GOC:mtg_heart] is_a: GO:0055006 ! cardiac cell development intersection_of: GO:0048468 ! cell development intersection_of: RO:0002296 CL:0002548 ! results in development of fibroblast of cardiac tissue relationship: BFO:0000050 GO:0060935 ! part of cardiac fibroblast cell differentiation relationship: RO:0002296 CL:0002548 ! results in development of fibroblast of cardiac tissue creation_date: 2009-09-29T01:23:03Z [Term] id: GO:0060945 name: cardiac neuron differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a neuron of the heart." [GOC:mtg_heart] synonym: "heart neuron differentiation" EXACT [GOC:mtg_heart] is_a: GO:0035051 ! cardiocyte differentiation is_a: GO:0048934 ! peripheral nervous system neuron differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0010022 ! results in acquisition of features of cardiac neuron relationship: BFO:0000050 GO:0048483 ! part of autonomic nervous system development relationship: RO:0002315 CL:0010022 ! results in acquisition of features of cardiac neuron creation_date: 2009-09-29T02:45:33Z [Term] id: GO:0060946 name: cardiac blood vessel endothelial cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a blood vessel endothelial cell of the heart. Blood vessel endothelial cells are thin flattened cells that line the inside surfaces of blood vessels." [GOC:mtg_heart] is_a: GO:0003348 ! cardiac endothelial cell differentiation is_a: GO:0060837 ! blood vessel endothelial cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0010006 ! results in acquisition of features of cardiac blood vessel endothelial cell relationship: RO:0002315 CL:0010006 ! results in acquisition of features of cardiac blood vessel endothelial cell creation_date: 2009-09-29T02:48:55Z [Term] id: GO:0060950 name: cardiac glial cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires the specialized features of a glial cell of the heart." [GOC:mtg_heart] is_a: GO:0010001 ! glial cell differentiation is_a: GO:0035051 ! cardiocyte differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0010020 ! results in acquisition of features of cardiac glial cell relationship: RO:0002315 CL:0010020 ! results in acquisition of features of cardiac glial cell creation_date: 2009-09-29T03:06:37Z [Term] id: GO:0060952 name: cardiac glial cell development namespace: biological_process def: "The process aimed at the progression of a cardiac glial cell over time, from its formation to the fully functional mature cell." [GOC:mtg_heart] is_a: GO:0021782 ! glial cell development is_a: GO:0055006 ! cardiac cell development intersection_of: GO:0048468 ! cell development intersection_of: RO:0002296 CL:0010020 ! results in development of cardiac glial cell relationship: BFO:0000050 GO:0060950 ! part of cardiac glial cell differentiation relationship: RO:0002296 CL:0010020 ! results in development of cardiac glial cell creation_date: 2009-09-29T03:09:24Z [Term] id: GO:0060956 name: endocardial cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of an endocardial cell. An endocardial cell is a specialized endothelial cell that makes up the endocardium portion of the heart. The endocardium is the innermost layer of tissue of the heart, and lines the heart chambers." [GOC:mtg_heart] is_a: GO:0003348 ! cardiac endothelial cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0002350 ! results in acquisition of features of endocardial cell relationship: BFO:0000050 GO:0003157 ! part of endocardium development relationship: RO:0002315 CL:0002350 ! results in acquisition of features of endocardial cell creation_date: 2009-09-29T03:20:39Z [Term] id: GO:0060958 name: endocardial cell development namespace: biological_process def: "The progression of an endocardial cell over time, from its formation to the mature cell. An endocardial cell is a specialized endothelial cell that makes up the endocardium portion of the heart." [GOC:mtg_heart] is_a: GO:0001885 ! endothelial cell development is_a: GO:0055006 ! cardiac cell development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 CL:0002350 ! results in development of endocardial cell relationship: BFO:0000050 GO:0060956 ! part of endocardial cell differentiation relationship: RO:0002296 CL:0002350 ! results in development of endocardial cell creation_date: 2009-09-29T03:26:59Z [Term] id: GO:0060959 name: cardiac neuron development namespace: biological_process def: "The process whose specific outcome is the progression of a cardiac neuron over time, from its formation to the mature state." [GOC:mtg_heart] synonym: "heart neuron development" EXACT [GOC:mtg_heart] is_a: GO:0048935 ! peripheral nervous system neuron development is_a: GO:0055006 ! cardiac cell development intersection_of: GO:0048468 ! cell development intersection_of: RO:0002296 CL:0010022 ! results in development of cardiac neuron relationship: BFO:0000050 GO:0060945 ! part of cardiac neuron differentiation relationship: RO:0002296 CL:0010022 ! results in development of cardiac neuron creation_date: 2009-09-30T10:14:56Z [Term] id: GO:0060973 name: cell migration involved in heart development namespace: biological_process def: "The orderly movement of a cell from one site to another that will contribute to the progression of the heart over time, from its initial formation, to the mature organ." [GOC:mtg_heart] is_a: GO:0016477 ! cell migration intersection_of: GO:0016477 ! cell migration intersection_of: BFO:0000050 GO:0007507 ! part of heart development relationship: BFO:0000050 GO:0007507 ! part of heart development creation_date: 2009-10-06T10:53:49Z [Term] id: GO:0060974 name: cell migration involved in heart formation namespace: biological_process def: "The orderly movement of a cell from one site to another that contribute to the formation of the heart. The initial heart structure is made up of mesoderm-derived heart progenitor cells and neural crest-derived cells." [GOC:mtg_heart] is_a: GO:0060973 ! cell migration involved in heart development intersection_of: GO:0016477 ! cell migration intersection_of: BFO:0000050 GO:0060914 ! part of heart formation relationship: BFO:0000050 GO:0060914 ! part of heart formation creation_date: 2009-10-06T10:56:33Z [Term] id: GO:0060976 name: coronary vasculature development namespace: biological_process def: "The process whose specific outcome is the progression of the blood vessels of the heart over time, from its formation to the mature structure." [GOC:mtg_heart] synonym: "cardiac blood vessel development" EXACT [GOC:mtg_heart] synonym: "cardiac vasculature development" EXACT [GOC:mtg_heart] synonym: "coronary blood vessel development" EXACT [GOC:mtg_heart] synonym: "heart blood vessel development" EXACT [GOC:mtg_heart] synonym: "heart vasculature development" EXACT [GOC:mtg_heart] is_a: GO:0001568 ! blood vessel development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0003498 ! results in development of heart blood vessel relationship: BFO:0000050 GO:0007507 ! part of heart development relationship: RO:0002296 UBERON:0003498 ! results in development of heart blood vessel creation_date: 2009-10-06T12:15:23Z [Term] id: GO:0060977 name: coronary vasculature morphogenesis namespace: biological_process def: "The process in which the anatomical structures of blood vessels of the heart are generated and organized. The blood vessel is the vasculature carrying blood." [GOC:mtg_heart] synonym: "cardiac blood vessel morphogenesis" EXACT [GOC:mtg_heart] synonym: "cardiac vasculature morphogenesis" EXACT [GOC:mtg_heart] synonym: "coronary blood vessel morphogenesis" EXACT [GOC:mtg_heart] synonym: "heart blood vessel morphogenesis" EXACT [GOC:mtg_heart] synonym: "heart vasculature morphogenesis" EXACT [GOC:mtg_heart] is_a: GO:0048514 ! blood vessel morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0003498 ! results in morphogenesis of heart blood vessel relationship: BFO:0000050 GO:0060976 ! part of coronary vasculature development relationship: RO:0002298 UBERON:0003498 ! results in morphogenesis of heart blood vessel creation_date: 2009-10-06T12:28:23Z [Term] id: GO:0060978 name: angiogenesis involved in coronary vascular morphogenesis namespace: biological_process def: "Blood vessel formation in the heart when new vessels emerge from the proliferation of pre-existing blood vessels." [GOC:mtg_heart] synonym: "angiogenesis involved in cardiac vascular morphogenesis" EXACT [GOC:mtg_heart] synonym: "angiogenesis involved in heart vascular morphogenesis" EXACT [GOC:mtg_heart] synonym: "coronary blood vessel angiogenesis" EXACT [GOC:mtg_heart] synonym: "coronary vasculature angiogenesis" EXACT [GOC:mtg_heart] is_a: GO:0001525 ! angiogenesis intersection_of: GO:0001525 ! angiogenesis intersection_of: BFO:0000050 GO:0060976 ! part of coronary vasculature development relationship: BFO:0000050 GO:0060977 ! part of coronary vasculature morphogenesis creation_date: 2009-10-06T02:02:12Z [Term] id: GO:0060979 name: vasculogenesis involved in coronary vascular morphogenesis namespace: biological_process def: "The differentiation of endothelial cells from progenitor cells that contributes to blood vessel development in the heart, and the de novo formation of blood vessels and tubes." [GOC:mtg_heart] synonym: "coronary vasculogenesis" EXACT [GOC:mtg_heart] synonym: "vasculogenesis involved in coronary blood vessel morphogenesis" EXACT [GOC:mtg_heart] is_a: GO:0001570 ! vasculogenesis intersection_of: GO:0001570 ! vasculogenesis intersection_of: BFO:0000050 GO:0060977 ! part of coronary vasculature morphogenesis relationship: BFO:0000050 GO:0060977 ! part of coronary vasculature morphogenesis creation_date: 2009-10-06T02:19:42Z [Term] id: GO:0060980 name: cell migration involved in coronary vasculogenesis namespace: biological_process def: "The orderly movement of a cell from one site to another that will contribute to the differentiation of an endothelial cell that will form the blood vessels of the heart." [GOC:mtg_heart] is_a: GO:0035441 ! cell migration involved in vasculogenesis is_a: GO:0060973 ! cell migration involved in heart development intersection_of: GO:0016477 ! cell migration intersection_of: BFO:0000050 GO:0060979 ! part of vasculogenesis involved in coronary vascular morphogenesis relationship: BFO:0000050 GO:0060979 ! part of vasculogenesis involved in coronary vascular morphogenesis creation_date: 2009-10-06T02:33:06Z [Term] id: GO:0060981 name: cell migration involved in coronary angiogenesis namespace: biological_process def: "The orderly movement of a cell from one site to another that will contribute to the formation of new blood vessels in the heart from pre-existing blood vessels." [GOC:mtg_heart] is_a: GO:0060973 ! cell migration involved in heart development intersection_of: GO:0016477 ! cell migration intersection_of: BFO:0000050 GO:0060978 ! part of angiogenesis involved in coronary vascular morphogenesis relationship: BFO:0000050 GO:0060978 ! part of angiogenesis involved in coronary vascular morphogenesis creation_date: 2009-10-06T02:49:12Z [Term] id: GO:0060982 name: coronary artery morphogenesis namespace: biological_process def: "The process in which the anatomical structures of coronary arteries are generated and organized. Coronary arteries are blood vessels that transport blood to the heart muscle." [GOC:mtg_heart] is_a: GO:0048844 ! artery morphogenesis is_a: GO:0060977 ! coronary vasculature morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0001621 ! results in morphogenesis of coronary artery relationship: RO:0002298 UBERON:0001621 ! results in morphogenesis of coronary artery creation_date: 2009-10-06T02:58:52Z [Term] id: GO:0060986 name: endocrine hormone secretion namespace: biological_process def: "The regulated release of a hormone into the circulatory system." [GOC:dph] is_a: GO:0046879 ! hormone secretion relationship: BFO:0000050 GO:0050886 ! part of endocrine process property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 creation_date: 2010-01-11T09:03:48Z [Term] id: GO:0060993 name: kidney morphogenesis namespace: biological_process def: "Morphogenesis of a kidney. A kidney is an organ that filters the blood and excretes the end products of body metabolism in the form of urine." [GOC:dph, GOC:mtg_kidney_jan10] is_a: GO:0009887 ! animal organ morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0002113 ! results in morphogenesis of kidney relationship: BFO:0000050 GO:0001822 ! part of kidney development relationship: RO:0002298 UBERON:0002113 ! results in morphogenesis of kidney creation_date: 2010-01-19T08:16:55Z [Term] id: GO:0060995 name: cell-cell signaling involved in kidney development namespace: biological_process def: "Any process that mediates the transfer of information from one cell to another and contributes to the progression of the kidney over time, from its formation to the mature organ." [GOC:dph, GOC:mtg_kidney_jan10] synonym: "cell-cell signalling involved in kidney development" EXACT [GOC:mah] is_a: GO:0007267 ! cell-cell signaling intersection_of: GO:0007267 ! cell-cell signaling intersection_of: BFO:0000050 GO:0001822 ! part of kidney development relationship: BFO:0000050 GO:0001822 ! part of kidney development creation_date: 2010-01-19T08:33:40Z [Term] id: GO:0061004 name: pattern specification involved in kidney development namespace: biological_process def: "Any developmental process that results in the creation of defined areas or spaces within the kidney to which cells respond and eventually are instructed to differentiate." [GOC:dph, GOC:mtg_kidney_jan10] synonym: "kidney pattern formation" RELATED [GOC:mtg_kidney_jan10] synonym: "kidney pattern specification" EXACT [GOC:mtg_kidney_jan10] synonym: "pattern formation involved in kidney development" RELATED [GOC:mtg_kidney_jan10] is_a: GO:0007389 ! pattern specification process intersection_of: GO:0007389 ! pattern specification process intersection_of: BFO:0000050 GO:0001822 ! part of kidney development relationship: BFO:0000050 GO:0001822 ! part of kidney development relationship: BFO:0000050 GO:0072048 ! part of renal system pattern specification creation_date: 2010-01-21T09:05:54Z [Term] id: GO:0061005 name: cell differentiation involved in kidney development namespace: biological_process def: "The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the cells of the kidney as it progresses from its formation to the mature state." [GOC:mtg_kidney_jan10] is_a: GO:0030154 ! cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: BFO:0000050 GO:0001822 ! part of kidney development relationship: BFO:0000050 GO:0001822 ! part of kidney development creation_date: 2010-01-21T09:13:55Z [Term] id: GO:0061006 name: regulation of cell proliferation involved in kidney morphogenesis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cell proliferation that contributes to the shaping of the kidney." [GOC:dph, GOC:mtg_kidney_jan10] is_a: GO:0042127 ! regulation of cell population proliferation intersection_of: GO:0042127 ! regulation of cell population proliferation intersection_of: BFO:0000050 GO:0060993 ! part of kidney morphogenesis relationship: BFO:0000050 GO:0060993 ! part of kidney morphogenesis creation_date: 2010-01-21T11:25:23Z [Term] id: GO:0061007 name: hepaticobiliary system process namespace: biological_process def: "A system process carried out by any of the organs or tissues of the hepaticobiliary system. The hepaticobiliary system is responsible for metabolic and catabolic processing of small molecules absorbed from the blood or gut, hormones and serum proteins, detoxification, storage of glycogen, triglycerides, metals and lipid soluble vitamins and excretion of bile. Included are the synthesis of albumin, blood coagulation factors, complement, and specific binding proteins." [GOC:dph] subset: goslim_generic synonym: "hepatobiliary system process" EXACT [GOC:dph] is_a: GO:0003008 ! system process property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 creation_date: 2010-01-22T09:09:10Z [Term] id: GO:0061008 name: hepaticobiliary system development namespace: biological_process def: "The progression of the hepaticobiliary system over time, from its formation to the mature structure. The hepaticobiliary system is responsible for metabolic and catabolic processing of small molecules absorbed from the blood or gut, hormones and serum proteins, detoxification, storage of glycogen, triglycerides, metals and lipid soluble vitamins and excretion of bile. Included are the synthesis of albumin, blood coagulation factors, complement, and specific binding proteins." [GOC:dph] synonym: "hepatobiliary system development" EXACT [GOC:dph] is_a: GO:0048731 ! system development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0002423 ! results in development of hepatobiliary system relationship: RO:0002296 UBERON:0002423 ! results in development of hepatobiliary system creation_date: 2010-01-22T09:11:59Z [Term] id: GO:0061009 name: common bile duct development namespace: biological_process def: "The progression of the common bile duct over time, from its formation to the mature structure. The common bile duct is formed from the joining of the common hepatic duct running from the liver, and the cystic duct running from the gallbladder. The common bile duct transports bile from the liver and gallbladder to the intestine." [PMID:20614624] synonym: "bile duct development" EXACT [GOC:dph] synonym: "CBD development" EXACT [PMID:20614624] synonym: "EHBD development" BROAD [PMID:20614624] synonym: "extrahepatic bile duct development" BROAD [PMID:20614624] is_a: GO:0035295 ! tube development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0002394 ! results in development of bile duct relationship: BFO:0000050 GO:0061008 ! part of hepaticobiliary system development relationship: RO:0002296 UBERON:0002394 ! results in development of bile duct creation_date: 2010-01-22T09:17:13Z [Term] id: GO:0061010 name: gallbladder development namespace: biological_process def: "The progression of the gallbladder over time, from its initial formation to the mature structure. The gallbladder is a cavitated organ that stores bile." [GOC:dph] is_a: GO:0048513 ! animal organ development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0002110 ! results in development of gallbladder relationship: BFO:0000050 GO:0061008 ! part of hepaticobiliary system development relationship: RO:0002296 UBERON:0002110 ! results in development of gallbladder creation_date: 2010-01-22T09:38:44Z [Term] id: GO:0061011 name: hepatic duct development namespace: biological_process def: "The progression of the hepatic duct over time, from its formation to the mature structure. The hepatic duct is the duct that leads from the liver to the common bile duct." [GOC:dph, PMID:20614624] is_a: GO:0061009 ! common bile duct development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0001175 ! results in development of common hepatic duct relationship: RO:0002296 UBERON:0001175 ! results in development of common hepatic duct creation_date: 2010-01-22T09:44:39Z [Term] id: GO:0061017 name: hepatoblast differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a hepatoblast. A hepatoblast is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into hepatocytes and cholangiocytes." [GOC:dph, PMID:15226394] is_a: GO:0030855 ! epithelial cell differentiation is_a: GO:0048863 ! stem cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:1000488 ! results in acquisition of features of cholangiocyte relationship: BFO:0000050 GO:0001889 ! part of liver development relationship: RO:0002315 CL:1000488 ! results in acquisition of features of cholangiocyte creation_date: 2010-02-02T09:08:03Z [Term] id: GO:0061024 name: membrane organization namespace: biological_process def: "A process which results in the assembly, arrangement of constituent parts, or disassembly of a membrane. A membrane is a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:dph, GOC:tb] subset: goslim_chembl subset: goslim_drosophila subset: goslim_generic subset: goslim_pir subset: goslim_pombe subset: goslim_prokaryote synonym: "cellular membrane organisation" EXACT [] synonym: "cellular membrane organization" EXACT [] synonym: "membrane organisation" EXACT [GOC:mah] synonym: "membrane organization and biogenesis" RELATED [GOC:mah] synonym: "single-organism membrane organization" RELATED [] xref: Reactome:R-HSA-199991 "Membrane Trafficking" is_a: GO:0016043 ! cellular component organization intersection_of: GO:0016043 ! cellular component organization intersection_of: RO:0002592 GO:0016020 ! results in organization of membrane relationship: RO:0002592 GO:0016020 ! results in organization of membrane creation_date: 2010-02-08T02:43:11Z [Term] id: GO:0061025 name: membrane fusion namespace: biological_process def: "The membrane organization process that joins two lipid bilayers to form a single membrane." [GOC:dph, GOC:tb] subset: goslim_yeast synonym: "cellular membrane fusion" EXACT [] synonym: "single-organism membrane fusion" RELATED [] xref: Wikipedia:Lipid_bilayer_fusion is_a: GO:0061024 ! membrane organization intersection_of: GO:0061024 ! membrane organization intersection_of: RO:0012008 GO:0016020 ! results in fusion of membrane relationship: RO:0012008 GO:0016020 ! results in fusion of membrane creation_date: 2010-02-08T02:48:06Z [Term] id: GO:0061027 name: umbilical cord development namespace: biological_process def: "The process whose specific outcome is the development of the umbilical cord, from its formation to the mature structure. The umbilical cord is an organ or embryonic origin consisting of the 2 umbilical arteries and the one umbilical vein. The umbilical cord connects the cardiovascular system of the fetus to the mother via the placenta." [GOC:BHF, GOC:dph] is_a: GO:0048856 ! anatomical structure development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0002331 ! results in development of umbilical cord relationship: RO:0002162 NCBITaxon:32525 ! in taxon Theria relationship: RO:0002296 UBERON:0002331 ! results in development of umbilical cord creation_date: 2010-02-09T09:09:22Z [Term] id: GO:0061029 name: eyelid development in camera-type eye namespace: biological_process def: "The progression of the eyelid in a camera-type eye from its formation to the mature state. The eyelid is a membranous cover that helps protect and lubricate the eye." [GOC:dph, GOC:yaf] is_a: GO:0048856 ! anatomical structure development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0001711 ! results in development of eyelid relationship: BFO:0000050 GO:0043010 ! part of camera-type eye development relationship: RO:0002296 UBERON:0001711 ! results in development of eyelid creation_date: 2010-02-09T09:36:11Z [Term] id: GO:0061030 name: epithelial cell differentiation involved in mammary gland alveolus development namespace: biological_process def: "The process in which a relatively unspecialized epithelial cell becomes a more specialized epithelial cell of the mammary gland alveolus." [GOC:dph, GOC:yaf] is_a: GO:0060644 ! mammary gland epithelial cell differentiation intersection_of: GO:0030855 ! epithelial cell differentiation intersection_of: BFO:0000050 GO:0060749 ! part of mammary gland alveolus development relationship: BFO:0000050 GO:0060749 ! part of mammary gland alveolus development creation_date: 2010-02-09T09:43:00Z [Term] id: GO:0061032 name: visceral serous pericardium development namespace: biological_process def: "The progression of the visceral serous pericardium from its formation to the mature structure. The visceral serous pericardium is the inner layer of the pericardium." [GOC:dph, GOC:yaf] synonym: "epicardium development" EXACT [GOC:dph] is_a: GO:0048856 ! anatomical structure development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0002425 ! results in development of visceral serous pericardium relationship: BFO:0000050 GO:0060039 ! part of pericardium development relationship: RO:0002296 UBERON:0002425 ! results in development of visceral serous pericardium creation_date: 2010-02-09T09:52:49Z [Term] id: GO:0061034 name: olfactory bulb mitral cell layer development namespace: biological_process def: "The progression of the olfactory bulb mitral cell layer over time from its initial formation until its mature state. The mitral cell layer is composed of pyramidal neurons whose cell bodies are located between the granule cell layer and the plexiform layer." [GOC:dph] is_a: GO:0048856 ! anatomical structure development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0004186 ! results in development of olfactory bulb mitral cell layer relationship: BFO:0000050 GO:0021772 ! part of olfactory bulb development relationship: RO:0002296 UBERON:0004186 ! results in development of olfactory bulb mitral cell layer creation_date: 2010-02-09T03:30:23Z [Term] id: GO:0061035 name: regulation of cartilage development namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of cartilage development, the process whose specific outcome is the progression of the cartilage over time, from its formation to the mature structure. Cartilage is a connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate." [GOC:dph] is_a: GO:2000026 ! regulation of multicellular organismal development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0051216 ! regulates cartilage development relationship: RO:0002211 GO:0051216 ! regulates cartilage development creation_date: 2010-02-09T03:41:35Z [Term] id: GO:0061036 name: positive regulation of cartilage development namespace: biological_process def: "Any process that increases the rate, frequency, or extent of cartilage development, the process whose specific outcome is the progression of the cartilage over time, from its formation to the mature structure. Cartilage is a connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate." [GOC:dph] is_a: GO:0051094 ! positive regulation of developmental process is_a: GO:0051240 ! positive regulation of multicellular organismal process is_a: GO:0061035 ! regulation of cartilage development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0051216 ! positively regulates cartilage development relationship: RO:0002213 GO:0051216 ! positively regulates cartilage development creation_date: 2010-02-09T03:41:35Z [Term] id: GO:0061037 name: negative regulation of cartilage development namespace: biological_process def: "Any process that decreases the rate, frequency, or extent of cartilage development, the process whose specific outcome is the progression of the cartilage over time, from its formation to the mature structure. Cartilage is a connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate." [GOC:dph] is_a: GO:0051093 ! negative regulation of developmental process is_a: GO:0051241 ! negative regulation of multicellular organismal process is_a: GO:0061035 ! regulation of cartilage development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0051216 ! negatively regulates cartilage development relationship: RO:0002212 GO:0051216 ! negatively regulates cartilage development creation_date: 2010-02-09T03:41:35Z [Term] id: GO:0061038 name: uterus morphogenesis namespace: biological_process def: "The process in which anatomical structures of the uterus are generated and organized." [GOC:BHF, GOC:dph] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0009887 ! animal organ morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0000995 ! results in morphogenesis of uterus relationship: BFO:0000050 GO:0060065 ! part of uterus development relationship: RO:0002298 UBERON:0000995 ! results in morphogenesis of uterus creation_date: 2010-02-22T11:12:35Z [Term] id: GO:0061040 name: female gonad morphogenesis namespace: biological_process def: "The process in which a female gonad is generated and organized." [GOC:BHF, GOC:dph] synonym: "ovary morphogenesis" RELATED [GOC:dph, GOC:tb] is_a: GO:0035262 ! gonad morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0000992 ! results in morphogenesis of ovary relationship: BFO:0000050 GO:0008585 ! part of female gonad development relationship: RO:0002298 UBERON:0000992 ! results in morphogenesis of ovary creation_date: 2010-02-22T11:29:28Z [Term] id: GO:0061041 name: regulation of wound healing namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of the series of events that restore integrity to a damaged tissue, following an injury." [GOC:BHF, GOC:dph] is_a: GO:1903034 ! regulation of response to wounding intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0042060 ! regulates wound healing relationship: RO:0002211 GO:0042060 ! regulates wound healing property_value: RO:0002161 NCBITaxon:4751 creation_date: 2010-02-25T10:14:37Z [Term] id: GO:0061045 name: negative regulation of wound healing namespace: biological_process def: "Any process that decreases the rate, frequency, or extent of the series of events that restore integrity to a damaged tissue, following an injury." [GOC:dph] is_a: GO:0032102 ! negative regulation of response to external stimulus is_a: GO:0061041 ! regulation of wound healing is_a: GO:1903035 ! negative regulation of response to wounding intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0042060 ! negatively regulates wound healing relationship: RO:0002212 GO:0042060 ! negatively regulates wound healing property_value: RO:0002161 NCBITaxon:4751 creation_date: 2010-02-25T10:33:30Z [Term] id: GO:0061046 name: regulation of branching involved in lung morphogenesis namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of the process in which a highly ordered sequence of patterning events generates the branched structures of the lung, consisting of reiterated combinations of bud outgrowth, elongation, and dichotomous subdivision of terminal units." [GOC:dph, GOC:yaf] is_a: GO:0060688 ! regulation of morphogenesis of a branching structure is_a: GO:1905330 ! regulation of morphogenesis of an epithelium intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0060441 ! regulates epithelial tube branching involved in lung morphogenesis relationship: RO:0002211 GO:0060441 ! regulates epithelial tube branching involved in lung morphogenesis creation_date: 2010-02-25T10:41:38Z [Term] id: GO:0061047 name: positive regulation of branching involved in lung morphogenesis namespace: biological_process def: "Any process that increases the rate, frequency, or extent of the process in which a highly ordered sequence of patterning events generates the branched structures of the lung, consisting of reiterated combinations of bud outgrowth, elongation, and dichotomous subdivision of terminal units." [GOC:dph, GOC:yaf] is_a: GO:0051240 ! positive regulation of multicellular organismal process is_a: GO:0061046 ! regulation of branching involved in lung morphogenesis is_a: GO:1905332 ! positive regulation of morphogenesis of an epithelium intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0060441 ! positively regulates epithelial tube branching involved in lung morphogenesis relationship: RO:0002213 GO:0060441 ! positively regulates epithelial tube branching involved in lung morphogenesis creation_date: 2010-02-25T10:50:01Z [Term] id: GO:0061048 name: negative regulation of branching involved in lung morphogenesis namespace: biological_process def: "Any process that decreases the rate, frequency, or extent of the process in which a highly ordered sequence of patterning events generates the branched structures of the lung, consisting of reiterated combinations of bud outgrowth, elongation, and dichotomous subdivision of terminal units." [GOC:dph, GOC:yaf] is_a: GO:0051241 ! negative regulation of multicellular organismal process is_a: GO:0061046 ! regulation of branching involved in lung morphogenesis is_a: GO:1905331 ! negative regulation of morphogenesis of an epithelium intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0060441 ! negatively regulates epithelial tube branching involved in lung morphogenesis relationship: RO:0002212 GO:0060441 ! negatively regulates epithelial tube branching involved in lung morphogenesis creation_date: 2010-02-25T10:51:31Z [Term] id: GO:0061049 name: cell growth involved in cardiac muscle cell development namespace: biological_process def: "The growth of a cardiac muscle cell, where growth contributes to the progression of the cell over time from its initial formation to its mature state." [GOC:dph] synonym: "cardiac muscle cell hypertrophy" RELATED [GOC:dph] synonym: "cardiomyocyte growth" RELATED [GOC:dph] synonym: "heart muscle cell growth" RELATED [GOC:dph] is_a: GO:0048588 ! developmental cell growth intersection_of: GO:0016049 ! cell growth intersection_of: BFO:0000050 GO:0055013 ! part of cardiac muscle cell development relationship: BFO:0000050 GO:0003301 ! part of physiological cardiac muscle hypertrophy relationship: BFO:0000050 GO:0055013 ! part of cardiac muscle cell development creation_date: 2010-02-25T12:56:07Z [Term] id: GO:0061050 name: regulation of cell growth involved in cardiac muscle cell development namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of the growth of a cardiac muscle cell, where growth contributes to the progression of the cell over time from its initial formation to its mature state." [GOC:dph] is_a: GO:0001558 ! regulation of cell growth is_a: GO:0055021 ! regulation of cardiac muscle tissue growth intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0061049 ! regulates cell growth involved in cardiac muscle cell development relationship: RO:0002211 GO:0061049 ! regulates cell growth involved in cardiac muscle cell development creation_date: 2010-02-25T01:05:16Z [Term] id: GO:0061051 name: positive regulation of cell growth involved in cardiac muscle cell development namespace: biological_process def: "Any process that increases the rate, frequency, or extent of the growth of a cardiac muscle cell, where growth contributes to the progression of the cell over time from its initial formation to its mature state." [GOC:dph] is_a: GO:0010613 ! positive regulation of cardiac muscle hypertrophy is_a: GO:0030307 ! positive regulation of cell growth is_a: GO:0051155 ! positive regulation of striated muscle cell differentiation is_a: GO:0055023 ! positive regulation of cardiac muscle tissue growth is_a: GO:0061050 ! regulation of cell growth involved in cardiac muscle cell development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0061049 ! positively regulates cell growth involved in cardiac muscle cell development relationship: RO:0002213 GO:0061049 ! positively regulates cell growth involved in cardiac muscle cell development creation_date: 2010-02-25T01:08:08Z [Term] id: GO:0061052 name: negative regulation of cell growth involved in cardiac muscle cell development namespace: biological_process def: "Any process that decreases the rate, frequency, or extent of the growth of a cardiac muscle cell, where growth contributes to the progression of the cell over time from its initial formation to its mature state." [GOC:dph] is_a: GO:0010614 ! negative regulation of cardiac muscle hypertrophy is_a: GO:0030308 ! negative regulation of cell growth is_a: GO:0051154 ! negative regulation of striated muscle cell differentiation is_a: GO:0055022 ! negative regulation of cardiac muscle tissue growth is_a: GO:0061050 ! regulation of cell growth involved in cardiac muscle cell development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0061049 ! negatively regulates cell growth involved in cardiac muscle cell development relationship: RO:0002212 GO:0061049 ! negatively regulates cell growth involved in cardiac muscle cell development creation_date: 2010-02-25T01:11:30Z [Term] id: GO:0061053 name: somite development namespace: biological_process def: "The progression of a somite from its initial formation to the mature structure. Somites are mesodermal clusters that are arranged segmentally along the anterior posterior axis of an embryo." [GOC:dph] is_a: GO:0060429 ! epithelium development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0002329 ! results in development of somite relationship: BFO:0000050 GO:0009790 ! part of embryo development relationship: RO:0002162 NCBITaxon:7711 ! in taxon Chordata relationship: RO:0002296 UBERON:0002329 ! results in development of somite creation_date: 2010-03-02T12:05:13Z [Term] id: GO:0061054 name: dermatome development namespace: biological_process def: "The progression of the dermatome over time, from its initial formation to the mature structure. The dermatome is the portion of a somite that will form skin." [GOC:dph] is_a: GO:0048856 ! anatomical structure development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0004016 ! results in development of dermatome relationship: BFO:0000050 GO:0061053 ! part of somite development relationship: RO:0002296 UBERON:0004016 ! results in development of dermatome creation_date: 2010-03-02T12:07:37Z [Term] id: GO:0061055 name: myotome development namespace: biological_process def: "The progression of the myotome over time, from its formation to the mature structure. The myotome is the portion of the somite that will give rise to muscle." [GOC:dph] is_a: GO:0048856 ! anatomical structure development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0003082 ! results in development of myotome relationship: BFO:0000050 GO:0061053 ! part of somite development relationship: RO:0002296 UBERON:0003082 ! results in development of myotome creation_date: 2010-03-02T12:11:01Z [Term] id: GO:0061056 name: sclerotome development namespace: biological_process def: "The progression of the sclerotome over time, from its initial formation to the mature structure. The sclerotome is the portion of the somite that will give rise to a vertebra." [GOC:dph] is_a: GO:0060485 ! mesenchyme development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0003089 ! results in development of sclerotome relationship: BFO:0000050 GO:0061053 ! part of somite development relationship: RO:0002296 UBERON:0003089 ! results in development of sclerotome creation_date: 2010-03-02T12:12:40Z [Term] id: GO:0061061 name: muscle structure development namespace: biological_process def: "The progression of a muscle structure over time, from its formation to its mature state. Muscle structures are contractile cells, tissues or organs that are found in multicellular organisms." [GOC:dph] subset: goslim_drosophila is_a: GO:0048856 ! anatomical structure development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0005090 ! results in development of muscle structure relationship: RO:0002296 UBERON:0005090 ! results in development of muscle structure creation_date: 2010-03-09T08:55:14Z [Term] id: GO:0061068 name: urethra development namespace: biological_process def: "The progression of the urethra over time from its initial formation to the mature structure. The urethra is a renal system organ that carries urine from the bladder to outside the body." [GOC:dph] is_a: GO:0048513 ! animal organ development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0000057 ! results in development of urethra relationship: BFO:0000050 GO:0072001 ! part of renal system development relationship: RO:0002296 UBERON:0000057 ! results in development of urethra creation_date: 2010-03-12T08:24:52Z [Term] id: GO:0061069 name: male urethra development namespace: biological_process def: "The progression of the male urethra over time from its initial formation to the mature structure. The male urethra is a renal system organ that carries urine from the bladder through the penis to outside the body." [GOC:dph] is_a: GO:0061068 ! urethra development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0001333 ! results in development of male urethra relationship: RO:0002296 UBERON:0001333 ! results in development of male urethra creation_date: 2010-03-12T08:28:19Z [Term] id: GO:0061070 name: female urethra development namespace: biological_process def: "The progression of the female urethra over time from its initial formation to the mature structure. The female urethra is a renal system organ that carries urine from the bladder to outside the body, exiting above the vaginal opening." [GOC:dph] is_a: GO:0061068 ! urethra development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0001334 ! results in development of female urethra relationship: RO:0002296 UBERON:0001334 ! results in development of female urethra creation_date: 2010-03-12T08:29:43Z [Term] id: GO:0061071 name: urethra epithelium development namespace: biological_process def: "The progression of the urethra epithelium over time from its initial formation to the mature structure. The urethra is a renal system organ that carries urine from the bladder to outside the body. The epithelium is the tubular, planar layer of cells through which the urine passes." [GOC:dph] is_a: GO:0035295 ! tube development is_a: GO:0060429 ! epithelium development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0002325 ! results in development of epithelium of urethra relationship: BFO:0000050 GO:0061068 ! part of urethra development relationship: RO:0002296 UBERON:0002325 ! results in development of epithelium of urethra creation_date: 2010-03-12T08:36:53Z [Term] id: GO:0061072 name: iris morphogenesis namespace: biological_process def: "The process in which the iris is generated and organized. The iris is an anatomical structure in the eye whose opening forms the pupil. The iris is responsible for controlling the diameter and size of the pupil and the amount of light reaching the retina." [GOC:dph] is_a: BFO:0000003 is_a: GO:0009653 ! anatomical structure morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0001769 ! results in morphogenesis of iris relationship: BFO:0000050 GO:0048593 ! part of camera-type eye morphogenesis relationship: RO:0002298 UBERON:0001769 ! results in morphogenesis of iris creation_date: 2010-03-16T10:48:42Z [Term] id: GO:0061073 name: ciliary body morphogenesis namespace: biological_process def: "The process in which the ciliary body generated and organized. The ciliary body is the circumferential tissue inside the eye composed of the ciliary muscle and ciliary processes." [GOC:dph] is_a: BFO:0000003 is_a: GO:0009653 ! anatomical structure morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0001775 ! results in morphogenesis of ciliary body relationship: BFO:0000050 GO:0048593 ! part of camera-type eye morphogenesis relationship: RO:0002298 UBERON:0001775 ! results in morphogenesis of ciliary body creation_date: 2010-03-16T10:55:19Z [Term] id: GO:0061074 name: regulation of neural retina development namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of neural retina development, the progression of the neural retina over time from its initial formation to the mature structure. The neural retina is the part of the retina that contains neurons and photoreceptor cells." [GOC:dph] is_a: GO:0050793 ! regulation of developmental process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0003407 ! regulates neural retina development relationship: RO:0002211 GO:0003407 ! regulates neural retina development creation_date: 2010-03-16T11:47:05Z [Term] id: GO:0061075 name: positive regulation of neural retina development namespace: biological_process def: "Any process that increases the rate, frequency, or extent of neural retina development, the progression of the neural retina over time from its initial formation to the mature structure. The neural retina is the part of the retina that contains neurons and photoreceptor cells." [GOC:dph] is_a: GO:0061074 ! regulation of neural retina development is_a: GO:1902868 ! positive regulation of retina development in camera-type eye intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0003407 ! positively regulates neural retina development relationship: RO:0002213 GO:0003407 ! positively regulates neural retina development creation_date: 2010-03-16T11:59:48Z [Term] id: GO:0061076 name: negative regulation of neural retina development namespace: biological_process def: "Any process that decreases the rate, frequency, or extent of neural retina development, the progression of the neural retina over time from its initial formation to the mature structure. The neural retina is the part of the retina that contains neurons and photoreceptor cells." [GOC:dph] is_a: GO:0061074 ! regulation of neural retina development is_a: GO:1902867 ! negative regulation of retina development in camera-type eye intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0003407 ! negatively regulates neural retina development relationship: RO:0002212 GO:0003407 ! negatively regulates neural retina development creation_date: 2010-03-16T12:46:11Z [Term] id: GO:0061080 name: right horn of sinus venosus development namespace: biological_process def: "The progression of the right horn of the sinus venosus from its formation to the mature structure." [GOC:dph] is_a: GO:0048856 ! anatomical structure development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0005092 ! results in development of right horn of sinus venosus relationship: BFO:0000050 GO:0003235 ! part of sinus venosus development relationship: RO:0002296 UBERON:0005092 ! results in development of right horn of sinus venosus creation_date: 2010-04-08T02:45:10Z [Term] id: GO:0061081 name: positive regulation of myeloid leukocyte cytokine production involved in immune response namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of the production of a cytokine that contributes to the immune response." [GOC:BHF, GOC:dph] synonym: "positive regulation of myeloid cell cytokine production involved in immune response" RELATED [GOC:dph] is_a: GO:0002720 ! positive regulation of cytokine production involved in immune response intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0061082 ! positively regulates myeloid leukocyte cytokine production relationship: RO:0002213 GO:0061082 ! positively regulates myeloid leukocyte cytokine production property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4895 property_value: RO:0002161 NCBITaxon:4932 creation_date: 2010-04-13T11:26:41Z [Term] id: GO:0061082 name: myeloid leukocyte cytokine production namespace: biological_process def: "Any process that contributes to cytokine production by a myeloid cell." [GOC:dph] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms. subset: gocheck_do_not_annotate is_a: GO:0002367 ! cytokine production involved in immune response property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4895 property_value: RO:0002161 NCBITaxon:4932 creation_date: 2010-04-13T11:29:42Z [Term] id: GO:0061097 name: regulation of protein tyrosine kinase activity namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of protein tyrosine kinase activity." [GOC:dph, GOC:tb] subset: gocheck_obsoletion_candidate is_a: GO:0045859 ! regulation of protein kinase activity is_a: GO:0050730 ! regulation of peptidyl-tyrosine phosphorylation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0004713 ! regulates protein tyrosine kinase activity relationship: RO:0002211 GO:0004713 ! regulates protein tyrosine kinase activity creation_date: 2010-04-26T02:34:53Z [Term] id: GO:0061098 name: positive regulation of protein tyrosine kinase activity namespace: biological_process def: "Any process that increases the rate, frequency, or extent of protein tyrosine kinase activity." [GOC:dph, GOC:tb] subset: gocheck_obsoletion_candidate is_a: GO:0045860 ! positive regulation of protein kinase activity is_a: GO:0050731 ! positive regulation of peptidyl-tyrosine phosphorylation is_a: GO:0061097 ! regulation of protein tyrosine kinase activity intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0004713 ! positively regulates protein tyrosine kinase activity relationship: RO:0002213 GO:0004713 ! positively regulates protein tyrosine kinase activity creation_date: 2010-04-26T02:34:53Z [Term] id: GO:0061099 name: negative regulation of protein tyrosine kinase activity namespace: biological_process def: "Any process that decreases the rate, frequency, or extent of protein tyrosine kinase activity." [GOC:dph, GOC:tb] subset: gocheck_obsoletion_candidate is_a: GO:0006469 ! negative regulation of protein kinase activity is_a: GO:0050732 ! negative regulation of peptidyl-tyrosine phosphorylation is_a: GO:0061097 ! regulation of protein tyrosine kinase activity intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0004713 ! negatively regulates protein tyrosine kinase activity relationship: RO:0002212 GO:0004713 ! negatively regulates protein tyrosine kinase activity creation_date: 2010-04-26T02:34:53Z [Term] id: GO:0061100 name: lung neuroendocrine cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a neuroendocrine cell of the lung epithelium." [GOC:dph, PMID:9126746] is_a: GO:0061101 ! neuroendocrine cell differentiation is_a: GO:0061140 ! lung secretory cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:1000223 ! results in acquisition of features of pulmonary neuroendocrine cell relationship: RO:0002315 CL:1000223 ! results in acquisition of features of pulmonary neuroendocrine cell creation_date: 2010-04-27T03:28:46Z [Term] id: GO:0061101 name: neuroendocrine cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized structural and/or functional features of a neuroendocrine cell. A neuroendocrine cell is a cell that receives input form a neuron which controls the secretion of an endocrine substance." [GOC:dph] is_a: GO:0030182 ! neuron differentiation is_a: GO:0060563 ! neuroepithelial cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000165 ! results in acquisition of features of neuroendocrine cell relationship: RO:0002315 CL:0000165 ! results in acquisition of features of neuroendocrine cell creation_date: 2010-04-28T09:42:20Z [Term] id: GO:0061102 name: stomach neuroendocrine cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a neuroendocrine cell of the stomach epithelium." [GOC:dph, PMID:18173746] synonym: "gastric neuroendocrine cell differentiation" RELATED [GOC:dph] is_a: GO:0035883 ! enteroendocrine cell differentiation is_a: GO:0061101 ! neuroendocrine cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:1000222 ! results in acquisition of features of stomach neuroendocrine cell relationship: BFO:0000050 GO:0062094 ! part of stomach development relationship: RO:0002315 CL:1000222 ! results in acquisition of features of stomach neuroendocrine cell creation_date: 2010-04-28T09:47:07Z [Term] id: GO:0061104 name: adrenal chromaffin cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized structural and/or functional features of an adrenal chromaffin cell. An adrenal chromaffin cell is a neuroendocrine cell that stores epinephrine secretory vesicles." [GOC:dph] is_a: GO:0002067 ! glandular epithelial cell differentiation is_a: GO:0061101 ! neuroendocrine cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:1000426 ! results in acquisition of features of chromaffin cell of adrenal gland relationship: BFO:0000050 GO:0030325 ! part of adrenal gland development relationship: RO:0002315 CL:1000426 ! results in acquisition of features of chromaffin cell of adrenal gland creation_date: 2010-04-29T08:27:53Z [Term] id: GO:0061105 name: regulation of stomach neuroendocrine cell differentiation namespace: biological_process def: "Any process that modulates the rate, frequency or extent of the differentiation of a neuroendocrine cell in the stomach." [GOC:dph] is_a: GO:0030856 ! regulation of epithelial cell differentiation is_a: GO:0045664 ! regulation of neuron differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0061102 ! regulates stomach neuroendocrine cell differentiation relationship: RO:0002211 GO:0061102 ! regulates stomach neuroendocrine cell differentiation creation_date: 2010-04-29T12:19:37Z [Term] id: GO:0061106 name: negative regulation of stomach neuroendocrine cell differentiation namespace: biological_process def: "Any process that decreases the rate, frequency or extent of the differentiation of a neuroendocrine cell in the stomach." [GOC:dph] is_a: GO:0002085 ! inhibition of neuroepithelial cell differentiation is_a: GO:0045665 ! negative regulation of neuron differentiation is_a: GO:0061105 ! regulation of stomach neuroendocrine cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0061102 ! negatively regulates stomach neuroendocrine cell differentiation relationship: RO:0002212 GO:0061102 ! negatively regulates stomach neuroendocrine cell differentiation creation_date: 2010-04-29T12:23:05Z [Term] id: GO:0061107 name: seminal vesicle development namespace: biological_process def: "The progression of the seminal vesicle over time, from its formation to the mature structure. The seminal vesicle is a gland that contributes to the production of semen." [GOC:dph] is_a: GO:0048608 ! reproductive structure development is_a: GO:0048732 ! gland development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0000998 ! results in development of seminal vesicle relationship: RO:0002162 NCBITaxon:7776 ! in taxon Gnathostomata relationship: RO:0002296 UBERON:0000998 ! results in development of seminal vesicle creation_date: 2010-04-30T10:17:30Z [Term] id: GO:0061108 name: seminal vesicle epithelium development namespace: biological_process def: "The progression of the seminal vesicle epithelium over time, from its formation to the mature structure." [GOC:dph] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0035295 ! tube development is_a: GO:0060429 ! epithelium development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0004805 ! results in development of seminal vesicle epithelium relationship: BFO:0000050 GO:0061107 ! part of seminal vesicle development relationship: RO:0002296 UBERON:0004805 ! results in development of seminal vesicle epithelium creation_date: 2010-04-30T10:19:54Z [Term] id: GO:0061109 name: dense core granule organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a dense core granule. A dense core granule is a secretory organelle found in endocrine cells." [GOC:dph] synonym: "dense core granule organisation" EXACT [GOC:mah] is_a: GO:0033363 ! secretory granule organization intersection_of: GO:0016043 ! cellular component organization intersection_of: RO:0002592 GO:0031045 ! results in organization of dense core granule relationship: RO:0002592 GO:0031045 ! results in organization of dense core granule creation_date: 2010-05-01T09:34:37Z [Term] id: GO:0061111 name: epithelial-mesenchymal cell signaling involved in lung development namespace: biological_process def: "Any process that results in the transfer of information from an epithelial cell to a mesenchymal cell and contributes to the progression of the lung over time from its initial formation to the mature organ." [GOC:dph] synonym: "epithelial-mesenchymal cell signalling involved in lung development" EXACT [GOC:mah] is_a: GO:0060495 ! cell-cell signaling involved in lung development is_a: GO:0060684 ! epithelial-mesenchymal cell signaling intersection_of: GO:0060684 ! epithelial-mesenchymal cell signaling intersection_of: BFO:0000050 GO:0030324 ! part of lung development creation_date: 2010-05-05T11:14:38Z [Term] id: GO:0061113 name: pancreas morphogenesis namespace: biological_process def: "Morphogenesis of the pancreas. Morphogenesis is the process in which anatomical structures are generated and organized." [GOC:dph] is_a: GO:0009887 ! animal organ morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0001264 ! results in morphogenesis of pancreas relationship: BFO:0000050 GO:0031016 ! part of pancreas development relationship: RO:0002298 UBERON:0001264 ! results in morphogenesis of pancreas creation_date: 2010-05-05T11:55:30Z [Term] id: GO:0061114 name: branching involved in pancreas morphogenesis namespace: biological_process def: "The process in which the branches of the pancreas are generated and organized." [GOC:dph] is_a: GO:0061138 ! morphogenesis of a branching epithelium intersection_of: GO:0061138 ! morphogenesis of a branching epithelium intersection_of: BFO:0000050 GO:0061113 ! part of pancreas morphogenesis relationship: BFO:0000050 GO:0061113 ! part of pancreas morphogenesis creation_date: 2010-05-05T12:03:04Z [Term] id: GO:0061117 name: negative regulation of heart growth namespace: biological_process def: "Any process that decreases the rate or extent of heart growth. Heart growth is the increase in size or mass of the heart." [GOC:dph, GOC:hjd] is_a: GO:0046621 ! negative regulation of organ growth is_a: GO:0060420 ! regulation of heart growth intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0060419 ! negatively regulates heart growth relationship: RO:0002212 GO:0060419 ! negatively regulates heart growth creation_date: 2010-05-17T07:31:28Z [Term] id: GO:0061130 name: pancreatic bud formation namespace: biological_process def: "The morphogenetic process in which the foregut region specified to become the pancreas forms a bud." [GOC:dph] is_a: GO:0048645 ! animal organ formation is_a: GO:0061114 ! branching involved in pancreas morphogenesis is_a: GO:0072175 ! epithelial tube formation intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0003922 ! results in formation of anatomical entity pancreatic epithelial bud relationship: RO:0002297 UBERON:0003922 ! results in formation of anatomical entity pancreatic epithelial bud creation_date: 2010-05-17T09:33:40Z [Term] id: GO:0061138 name: morphogenesis of a branching epithelium namespace: biological_process def: "The process in which the anatomical structures of a branched epithelium are generated and organized." [GOC:dph] is_a: GO:0001763 ! morphogenesis of a branching structure is_a: GO:0002009 ! morphogenesis of an epithelium creation_date: 2010-05-25T09:05:34Z [Term] id: GO:0061140 name: lung secretory cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a lung secretory cell. A lung secretory cell is a specialized epithelial cell of the lung that contains large secretory granules in its apical part." [GOC:dph] is_a: GO:0060487 ! lung epithelial cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:1000272 ! results in acquisition of features of lung secretory cell relationship: RO:0002315 CL:1000272 ! results in acquisition of features of lung secretory cell creation_date: 2010-05-25T09:28:53Z [Term] id: GO:0061141 name: lung ciliated cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a lung ciliated cell. A lung ciliated cell is a specialized lung epithelial cell that contains cilia for moving substances released from lung secretory cells." [GOC:cilia, GOC:dph, GOC:krc] is_a: GO:0060487 ! lung epithelial cell differentiation is_a: GO:1903251 ! multi-ciliated epithelial cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:1000271 ! results in acquisition of features of lung multiciliated epithelial cell relationship: RO:0002315 CL:1000271 ! results in acquisition of features of lung multiciliated epithelial cell creation_date: 2010-05-25T09:31:14Z [Term] id: GO:0061146 name: Peyer's patch morphogenesis namespace: biological_process def: "The process in which a Peyer's patch is generated and organized. Peyer's patches are typically found as nodules associated with gut epithelium with distinct internal structures including B- and T-zones for the activation of lymphocytes." [GOC:dph] is_a: GO:0048729 ! tissue morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0001211 ! results in morphogenesis of Peyer's patch relationship: BFO:0000050 GO:0048541 ! part of Peyer's patch development relationship: RO:0002298 UBERON:0001211 ! results in morphogenesis of Peyer's patch creation_date: 2010-05-26T06:46:23Z [Term] id: GO:0061147 name: endocardial endothelium development namespace: biological_process def: "The progression of the endocardial endothelium over time, from its initial formation to the mature structure. The endocardium is an anatomical structure comprised of an endothelium and an extracellular matrix that forms the innermost layer of tissue of the heart, and lines the heart chambers." [GOC:dph] is_a: GO:0003158 ! endothelium development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0005316 ! results in development of endocardial endothelium relationship: BFO:0000050 GO:0003157 ! part of endocardium development relationship: RO:0002296 UBERON:0005316 ! results in development of endocardial endothelium creation_date: 2010-06-03T09:15:31Z [Term] id: GO:0061148 name: extracellular matrix organization involved in endocardium development namespace: biological_process def: "A process which results in the assembly, arrangement of constituent parts, or disassembly of an extracellular matrix of the endocardium. The endocardium is an anatomical structure comprised of an endothelium and an extracellular matrix that forms the innermost layer of tissue of the heart, and lines the heart chambers." [GOC:dph] synonym: "extracellular matrix organisation involved in endocardium development" EXACT [GOC:mah] is_a: GO:0030198 ! extracellular matrix organization intersection_of: GO:0030198 ! extracellular matrix organization intersection_of: BFO:0000050 GO:0003157 ! part of endocardium development relationship: BFO:0000050 GO:0003157 ! part of endocardium development creation_date: 2010-06-03T09:18:02Z [Term] id: GO:0061152 name: trachea submucosa development namespace: biological_process def: "The progression of the trachea submucosa over time from its formation to the mature structure. The trachea submucosa is made up of the glands and elastic tissue that lie under the mucosa in the trachea." [GOC:dph, GOC:yaf] is_a: GO:0048856 ! anatomical structure development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0002202 ! results in development of submucosa of trachea relationship: BFO:0000050 GO:0060438 ! part of trachea development relationship: RO:0002296 UBERON:0002202 ! results in development of submucosa of trachea creation_date: 2010-06-07T09:58:40Z [Term] id: GO:0061153 name: trachea gland development namespace: biological_process def: "The progression of a trachea gland over time, from its formation to the mature structure. Trachea glands are found under the mucus of the trachea and secrete mucus, and agents that help protect the lung from injury and infection." [GOC:dph] is_a: GO:0048732 ! gland development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0005203 ! results in development of trachea gland relationship: BFO:0000050 GO:0061152 ! part of trachea submucosa development relationship: RO:0002296 UBERON:0005203 ! results in development of trachea gland creation_date: 2010-06-07T10:10:51Z [Term] id: GO:0061154 name: endothelial tube morphogenesis namespace: biological_process def: "The process in which the anatomical structures of a tube are generated and organized from an endothelium. Endothelium refers to the layer of cells lining blood vessels, lymphatics, the heart, and serous cavities, and is derived from bone marrow or mesoderm. Corneal endothelium is a special case, derived from neural crest cells." [GOC:dph, GOC:yaf] is_a: GO:0003159 ! morphogenesis of an endothelium is_a: GO:0060562 ! epithelial tube morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0003915 ! results in morphogenesis of endothelial tube relationship: RO:0002298 UBERON:0003915 ! results in morphogenesis of endothelial tube creation_date: 2010-06-15T09:05:00Z [Term] id: GO:0061155 name: pulmonary artery endothelial tube morphogenesis namespace: biological_process def: "The process in which the anatomical structures of a tube are generated and organized from the pulmonary artery endothelium. An pulmonary artery endothelium is an epithelium that lines the pulmonary artery." [GOC:dph, GOC:yaf] is_a: GO:0061154 ! endothelial tube morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0005317 ! results in morphogenesis of pulmonary artery endothelium relationship: BFO:0000050 GO:0061156 ! part of pulmonary artery morphogenesis relationship: RO:0002298 UBERON:0005317 ! results in morphogenesis of pulmonary artery endothelium creation_date: 2010-06-15T09:09:04Z [Term] id: GO:0061156 name: pulmonary artery morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the pulmonary artery are generated and organized. The pulmonary artery is the artery that carries blood from the heart to the lungs." [GOC:dph, GOC:yaf] is_a: GO:0048844 ! artery morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0002012 ! results in morphogenesis of pulmonary artery relationship: RO:0002298 UBERON:0002012 ! results in morphogenesis of pulmonary artery creation_date: 2010-06-15T09:13:47Z [Term] id: GO:0061168 name: regulation of hair follicle placode formation namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of hair follicle placode formation, the developmental process in which a hair placode forms. An hair follicle placode is a thickening of the ectoderm that will give rise to the hair follicle bud." [GOC:dph] is_a: GO:0022603 ! regulation of anatomical structure morphogenesis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0060789 ! regulates hair follicle placode formation relationship: RO:0002211 GO:0060789 ! regulates hair follicle placode formation creation_date: 2010-06-25T01:03:29Z [Term] id: GO:0061169 name: positive regulation of hair placode formation namespace: biological_process def: "Any process that increases the rate, frequency, or extent of hair follicle placode formation, the developmental process in which a hair placode forms. An hair follicle placode is a thickening of the ectoderm that will give rise to the hair follicle bud." [GOC:dph] is_a: GO:0051094 ! positive regulation of developmental process is_a: GO:0061168 ! regulation of hair follicle placode formation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0060789 ! positively regulates hair follicle placode formation relationship: RO:0002213 GO:0060789 ! positively regulates hair follicle placode formation creation_date: 2010-06-25T01:08:50Z [Term] id: GO:0061170 name: negative regulation of hair follicle placode formation namespace: biological_process def: "Any process that decreases the rate, frequency, or extent of hair follicle placode formation, the developmental process in which a hair placode forms. An hair follicle placode is a thickening of the ectoderm that will give rise to the hair follicle bud." [GOC:dph] is_a: GO:0051799 ! negative regulation of hair follicle development is_a: GO:0061168 ! regulation of hair follicle placode formation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0060789 ! negatively regulates hair follicle placode formation relationship: RO:0002212 GO:0060789 ! negatively regulates hair follicle placode formation creation_date: 2010-06-25T01:10:48Z [Term] id: GO:0061178 name: regulation of insulin secretion involved in cellular response to glucose stimulus namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the regulated release of insulin that contributes to the response of a cell to glucose." [GOC:BHF, GOC:dph] synonym: "regulation of insulin secretion in response to glucose" EXACT [GOC:dph] is_a: GO:0050796 ! regulation of insulin secretion is_a: GO:0060341 ! regulation of cellular localization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0035773 ! regulates insulin secretion involved in cellular response to glucose stimulus relationship: RO:0002211 GO:0035773 ! regulates insulin secretion involved in cellular response to glucose stimulus creation_date: 2010-07-13T09:38:42Z [Term] id: GO:0061179 name: negative regulation of insulin secretion involved in cellular response to glucose stimulus namespace: biological_process def: "Any process that decreases the frequency, rate or extent of the regulated release of insulin that contributes to the response of a cell to glucose." [GOC:BHF, GOC:dph] synonym: "negative regulation of insulin secretion in response to glucose" RELATED [GOC:dph] synonym: "negative regulation of insulin secretion involved in cellular response to glucose" EXACT [GOC:bf] is_a: GO:0046676 ! negative regulation of insulin secretion is_a: GO:0048585 ! negative regulation of response to stimulus is_a: GO:0061178 ! regulation of insulin secretion involved in cellular response to glucose stimulus intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0035773 ! negatively regulates insulin secretion involved in cellular response to glucose stimulus relationship: RO:0002212 GO:0035773 ! negatively regulates insulin secretion involved in cellular response to glucose stimulus creation_date: 2010-07-13T09:41:46Z [Term] id: GO:0061180 name: mammary gland epithelium development namespace: biological_process def: "The process whose specific outcome is the progression of the mammary gland epithelium over time, from its formation to the mature structure. The mammary gland is a large compound sebaceous gland that in female mammals is modified to secrete milk." [GOC:dph, GOC:yaf] synonym: "breast epithelium development" EXACT [GOC:dph] is_a: GO:0060429 ! epithelium development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0008367 ! results in development of breast epithelium relationship: BFO:0000050 GO:0030879 ! part of mammary gland development relationship: RO:0002296 UBERON:0008367 ! results in development of breast epithelium creation_date: 2010-07-14T08:18:24Z [Term] id: GO:0061181 name: regulation of chondrocyte development namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of the process whose specific outcome is the progression of a chondrocyte over time, from its commitment to its mature state. Chondrocyte development does not include the steps involved in committing a chondroblast to a chondrocyte fate." [GOC:BHF, GOC:dph] is_a: GO:0032330 ! regulation of chondrocyte differentiation is_a: GO:0060284 ! regulation of cell development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0002063 ! regulates chondrocyte development relationship: RO:0002211 GO:0002063 ! regulates chondrocyte development creation_date: 2010-07-14T08:28:52Z [Term] id: GO:0061182 name: negative regulation of chondrocyte development namespace: biological_process def: "Any process that decreases the rate, frequency, or extent of the process whose specific outcome is the progression of a chondrocyte over time, from its commitment to its mature state. Chondrocyte development does not include the steps involved in committing a chondroblast to a chondrocyte fate." [GOC:BHF, GOC:dph] is_a: GO:0010721 ! negative regulation of cell development is_a: GO:0032331 ! negative regulation of chondrocyte differentiation is_a: GO:0061181 ! regulation of chondrocyte development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0002063 ! negatively regulates chondrocyte development relationship: RO:0002212 GO:0002063 ! negatively regulates chondrocyte development creation_date: 2010-07-14T08:33:05Z [Term] id: GO:0061183 name: regulation of dermatome development namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of the progression of the dermatome over time, from its initial formation to the mature structure. The dermatome is the portion of a somite that will form skin." [GOC:BHF, GOC:dph] is_a: GO:0050793 ! regulation of developmental process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0061054 ! regulates dermatome development relationship: RO:0002211 GO:0061054 ! regulates dermatome development creation_date: 2010-07-14T08:40:26Z [Term] id: GO:0061184 name: positive regulation of dermatome development namespace: biological_process def: "Any process that increases the rate, frequency, or extent of the progression of the dermatome over time, from its initial formation to the mature structure. The dermatome is the portion of a somite that will form skin." [GOC:BHF, GOC:dph] is_a: GO:0040019 ! positive regulation of embryonic development is_a: GO:0061183 ! regulation of dermatome development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0061054 ! positively regulates dermatome development relationship: RO:0002213 GO:0061054 ! positively regulates dermatome development creation_date: 2010-07-14T08:42:03Z [Term] id: GO:0061185 name: negative regulation of dermatome development namespace: biological_process def: "Any process that decreases the rate, frequency, or extent of the progression of the dermatome over time, from its initial formation to the mature structure. The dermatome is the portion of a somite that will form skin." [GOC:BHF, GOC:dph] is_a: GO:0045992 ! negative regulation of embryonic development is_a: GO:0061183 ! regulation of dermatome development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0061054 ! negatively regulates dermatome development relationship: RO:0002212 GO:0061054 ! negatively regulates dermatome development creation_date: 2010-07-14T08:43:08Z [Term] id: GO:0061189 name: positive regulation of sclerotome development namespace: biological_process def: "Any process that increases the rate, frequency, or extent of the progression of the sclerotome over time, from its initial formation to the mature structure. The sclerotome is the portion of the somite that will give rise to a vertebra." [GOC:BHF, GOC:dph] is_a: GO:0051094 ! positive regulation of developmental process is_a: GO:0061190 ! regulation of sclerotome development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0061056 ! positively regulates sclerotome development relationship: RO:0002213 GO:0061056 ! positively regulates sclerotome development creation_date: 2010-07-14T09:17:23Z [Term] id: GO:0061190 name: regulation of sclerotome development namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of the progression of the sclerotome over time, from its initial formation to the mature structure. The sclerotome is the portion of the somite that will give rise to a vertebra." [GOC:dph] is_a: GO:0050793 ! regulation of developmental process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0061056 ! regulates sclerotome development relationship: RO:0002211 GO:0061056 ! regulates sclerotome development creation_date: 2010-07-14T09:19:47Z [Term] id: GO:0061193 name: taste bud development namespace: biological_process def: "The progression of the taste bud over time, from its formation to the mature state. The taste bud is a specialized area of the tongue that contains taste receptors." [GOC:dph] is_a: GO:0007423 ! sensory organ development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0001727 ! results in development of taste bud relationship: BFO:0000050 GO:0043586 ! part of tongue development relationship: RO:0002296 UBERON:0001727 ! results in development of taste bud creation_date: 2010-07-27T10:55:08Z [Term] id: GO:0061194 name: taste bud morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the taste bud are generated and organized. The taste bud is a specialized area of the tongue that contains taste receptors." [GOC:dph] is_a: GO:0090596 ! sensory organ morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0001727 ! results in morphogenesis of taste bud relationship: BFO:0000050 GO:0043587 ! part of tongue morphogenesis relationship: BFO:0000050 GO:0061193 ! part of taste bud development relationship: RO:0002298 UBERON:0001727 ! results in morphogenesis of taste bud creation_date: 2010-07-27T11:01:31Z [Term] id: GO:0061195 name: taste bud formation namespace: biological_process def: "The developmental process pertaining to the initial formation of the taste bud from unspecified parts. The taste bud is a specialized area of the tongue that contains taste receptors." [GOC:dph] is_a: BFO:0000003 is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0001727 ! results in formation of anatomical entity taste bud relationship: BFO:0000050 GO:0061194 ! part of taste bud morphogenesis relationship: RO:0002297 UBERON:0001727 ! results in formation of anatomical entity taste bud creation_date: 2010-07-27T12:22:26Z [Term] id: GO:0061205 name: paramesonephric duct development namespace: biological_process def: "The process whose specific outcome is the progression of the paramesonephric duct over time, from its formation to the mature structure. Mullerian ducts (or paramesonephric ducts) are paired ducts of the embryo that run down the lateral sides of the urogenital ridge and terminate at the mullerian eminence in the primitive urogenital sinus. In the female, they will develop to form the fallopian tubes, uterus, cervix, and the upper portion of the vagina; in the male, they are lost. These ducts are made of tissue of mesodermal origin." [GOC:dph, GOC:yaf] synonym: "Mullerian duct development" EXACT [GOC:dph] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0035295 ! tube development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0003890 ! results in development of Mullerian duct relationship: RO:0002296 UBERON:0003890 ! results in development of Mullerian duct creation_date: 2010-07-30T10:54:47Z [Term] id: GO:0061206 name: mesonephros morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the mesonephros are generated and organized." [GOC:mtg_kidney_jan10] synonym: "Wolffian body morphogenesis" EXACT [GOC:dph] is_a: GO:0060993 ! kidney morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0000080 ! results in morphogenesis of mesonephros relationship: BFO:0000050 GO:0001823 ! part of mesonephros development relationship: RO:0002298 UBERON:0000080 ! results in morphogenesis of mesonephros creation_date: 2010-08-17T03:11:10Z [Term] id: GO:0061208 name: cell differentiation involved in mesonephros development namespace: biological_process def: "The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the cells of the mesonephros as it progresses from its formation to the mature state." [GOC:mtg_kidney_jan10] is_a: GO:0061005 ! cell differentiation involved in kidney development intersection_of: GO:0030154 ! cell differentiation intersection_of: BFO:0000050 GO:0001823 ! part of mesonephros development relationship: BFO:0000050 GO:0001823 ! part of mesonephros development creation_date: 2010-08-17T03:21:23Z [Term] id: GO:0061209 name: cell proliferation involved in mesonephros development namespace: biological_process def: "The multiplication or reproduction of cells, resulting in the expansion of the population in the mesonephros." [GOC:mtg_kidney_jan10] is_a: GO:0072111 ! cell proliferation involved in kidney development intersection_of: GO:0008283 ! cell population proliferation intersection_of: BFO:0000050 GO:0001823 ! part of mesonephros development relationship: BFO:0000050 GO:0001823 ! part of mesonephros development creation_date: 2010-08-17T03:22:46Z [Term] id: GO:0061210 name: cell-cell signaling involved in mesonephros development namespace: biological_process def: "Any process that mediates the transfer of information from one cell to another and contributes to the progression of the mesonephros over time, from its formation to the mature organ." [GOC:mtg_kidney_jan10] synonym: "cell-cell signalling involved in mesonephros development" EXACT [GOC:mah] is_a: GO:0060995 ! cell-cell signaling involved in kidney development intersection_of: GO:0007267 ! cell-cell signaling intersection_of: BFO:0000050 GO:0001823 ! part of mesonephros development relationship: BFO:0000050 GO:0001823 ! part of mesonephros development creation_date: 2010-08-17T03:24:08Z [Term] id: GO:0061211 name: mesonephric collecting duct development namespace: biological_process def: "The process whose specific outcome is the progression of a collecting duct in the mesonephros over time, from its formation to the mature structure. The collecting duct regulates water, electrolyte and acid-base balance. The collecting duct is the final common path through which urine flows before entering the ureter and then emptying into the bladder." [GOC:mtg_kidney_jan10] is_a: GO:0072044 ! collecting duct development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0005319 ! results in development of mesonephric collecting duct relationship: BFO:0000050 GO:0001823 ! part of mesonephros development relationship: RO:0002296 UBERON:0005319 ! results in development of mesonephric collecting duct creation_date: 2010-08-17T03:25:51Z [Term] id: GO:0061212 name: mesonephric juxtaglomerular apparatus development namespace: biological_process def: "The process whose specific outcome is the progression of the juxtaglomerular apparatus in the mesonephros over time, from its formation to the mature structure. The juxtaglomerular apparatus is an anatomical structure which consists of juxtaglomerular cells, extraglomerular mesangial cells and the macula densa. The juxtaglomerular apparatus lies adjacent to the glomerulus and regulates kidney function by maintaining the blood flow to the kidney and the filtration rate." [GOC:mtg_kidney_jan10] is_a: GO:0072051 ! juxtaglomerular apparatus development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0005320 ! results in development of mesonephric juxtaglomerular apparatus relationship: BFO:0000050 GO:0001823 ! part of mesonephros development relationship: RO:0002296 UBERON:0005320 ! results in development of mesonephric juxtaglomerular apparatus creation_date: 2010-08-17T03:27:36Z [Term] id: GO:0061213 name: positive regulation of mesonephros development namespace: biological_process def: "Any process that increases the rate, frequency or extent of mesonephros development. Mesonephros development is the process whose specific outcome is the progression of the mesonephros over time, from its formation to the mature structure. The mesonephros is an organ that filters the blood and excretes the end products of body metabolism in the form of urine." [GOC:mtg_kidney_jan10] is_a: GO:0061217 ! regulation of mesonephros development is_a: GO:0090184 ! positive regulation of kidney development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0001823 ! positively regulates mesonephros development relationship: RO:0002213 GO:0001823 ! positively regulates mesonephros development creation_date: 2010-08-17T03:39:35Z [Term] id: GO:0061214 name: mesonephric smooth muscle tissue development namespace: biological_process def: "The process whose specific outcome is the progression of smooth muscle in the mesonephros over time, from its formation to the mature structure." [GOC:mtg_kidney_jan10] is_a: GO:0072194 ! kidney smooth muscle tissue development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0005321 ! results in development of mesonephric smooth muscle tissue relationship: BFO:0000050 GO:0001823 ! part of mesonephros development relationship: RO:0002296 UBERON:0005321 ! results in development of mesonephric smooth muscle tissue creation_date: 2010-08-17T03:29:54Z [Term] id: GO:0061215 name: mesonephric nephron development namespace: biological_process def: "The process whose specific outcome is the progression of a nephron in the mesonephros over time, from its formation to the mature structure. A nephron is the functional unit of the kidney." [GOC:mtg_kidney_jan10] is_a: GO:0072006 ! nephron development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0005322 ! results in development of mesonephric nephron relationship: BFO:0000050 GO:0001823 ! part of mesonephros development relationship: RO:0002296 UBERON:0005322 ! results in development of mesonephric nephron creation_date: 2010-08-17T03:31:08Z [Term] id: GO:0061217 name: regulation of mesonephros development namespace: biological_process def: "Any process that modulates the rate, frequency or extent of mesonephros development. Mesonephros development is the process whose specific outcome is the progression of the mesonephros over time, from its formation to the mature structure. The mesonephros is an endocrine and metabolic organ that filters the blood and excretes the end products of body metabolism in the form of urine." [GOC:mtg_kidney_jan10] is_a: GO:0090183 ! regulation of kidney development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0001823 ! regulates mesonephros development relationship: RO:0002211 GO:0001823 ! regulates mesonephros development creation_date: 2010-08-17T03:35:31Z [Term] id: GO:0061218 name: negative regulation of mesonephros development namespace: biological_process def: "Any process that decreases the rate, frequency or extent of mesonephros development. Mesonephros development is the process whose specific outcome is the progression of the mesonephros over time, from its formation to the mature structure. The mesonephros is an organ that filters the blood and excretes the end products of body metabolism in the form of urine." [GOC:mtg_kidney_jan10] is_a: GO:0061217 ! regulation of mesonephros development is_a: GO:0090185 ! negative regulation of kidney development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0001823 ! negatively regulates mesonephros development relationship: RO:0002212 GO:0001823 ! negatively regulates mesonephros development creation_date: 2010-08-17T03:43:06Z [Term] id: GO:0061219 name: mesonephric mesenchyme development namespace: biological_process def: "The biological process whose specific outcome is the progression of a mesonephric mesenchyme from an initial condition to its mature state. This process begins with the formation of mesonephric mesenchyme and ends with the mature structure. Mesonephric mesenchyme is the tissue made up of loosely connected mesenchymal cells in the mesonephros." [GOC:mtg_kidney_jan10] is_a: GO:0072074 ! kidney mesenchyme development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0005323 ! results in development of mesonephric mesenchyme relationship: BFO:0000050 GO:0001823 ! part of mesonephros development relationship: RO:0002296 UBERON:0005323 ! results in development of mesonephric mesenchyme creation_date: 2010-08-17T03:45:44Z [Term] id: GO:0061220 name: mesonephric macula densa development namespace: biological_process def: "The process whose specific outcome is the progression of the mesonephric macula densa over time, from its formation to the mature structure. The mesonephric macula densa is an area of specialized cells in the distal tubule of the mesonephros that makes contact with the vascular pole of the glomerulus." [GOC:mtg_kidney_jan10] is_a: GO:0061241 ! mesonephric nephron epithelium development is_a: GO:0072024 ! macula densa development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0005324 ! results in development of mesonephric macula densa relationship: BFO:0000050 GO:0061212 ! part of mesonephric juxtaglomerular apparatus development relationship: RO:0002296 UBERON:0005324 ! results in development of mesonephric macula densa creation_date: 2010-08-19T01:11:41Z [Term] id: GO:0061221 name: mesonephric mesenchyme morphogenesis namespace: biological_process def: "The process in which the anatomical structures of a mesonephric mesenchymal tissue are generated and organized. Mesonephric mesenchyme is the tissue made up of loosely connected mesenchymal cells in the mesonephros." [GOC:mtg_kidney_jan10] is_a: GO:0072131 ! kidney mesenchyme morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0005323 ! results in morphogenesis of mesonephric mesenchyme relationship: BFO:0000050 GO:0061219 ! part of mesonephric mesenchyme development relationship: RO:0002298 UBERON:0005323 ! results in morphogenesis of mesonephric mesenchyme creation_date: 2010-08-19T01:17:38Z [Term] id: GO:0061224 name: mesonephric glomerulus development namespace: biological_process def: "The progression of the mesonephric glomerulus over time from its initial formation until its mature state. The mesonephric glomerulus is a capillary tuft which forms a close network with the visceral epithelium (podocytes) and the mesangium to form the filtration barrier and is surrounded by Bowman's capsule in nephrons of the mature vertebrate kidney, or mesonephros." [GOC:mtg_kidney_jan10] is_a: GO:0032835 ! glomerulus development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0005325 ! results in development of mesonephric glomerulus relationship: BFO:0000050 GO:0061215 ! part of mesonephric nephron development relationship: RO:0002296 UBERON:0005325 ! results in development of mesonephric glomerulus creation_date: 2010-08-19T01:26:00Z [Term] id: GO:0061227 name: pattern specification involved in mesonephros development namespace: biological_process def: "Any developmental process that results in the creation of defined areas or spaces within the mesonephros to which cells respond and eventually are instructed to differentiate." [GOC:mtg_kidney_jan10] synonym: "mesonephros pattern formation" RELATED [GOC:mtg_kidney_jan10] synonym: "mesonephros pattern specification" EXACT [GOC:mtg_kidney_jan10] is_a: GO:0061004 ! pattern specification involved in kidney development intersection_of: GO:0007389 ! pattern specification process intersection_of: BFO:0000050 GO:0001823 ! part of mesonephros development relationship: BFO:0000050 GO:0001823 ! part of mesonephros development creation_date: 2010-08-19T02:22:22Z [Term] id: GO:0061228 name: mesonephric nephron morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the mesonephric nephron are generated and organized. A mesonephric nephron is the functional unit of the mesonephros." [GOC:mtg_kidney_jan10] is_a: GO:0072028 ! nephron morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0005322 ! results in morphogenesis of mesonephric nephron relationship: BFO:0000050 GO:0061206 ! part of mesonephros morphogenesis relationship: BFO:0000050 GO:0061215 ! part of mesonephric nephron development relationship: RO:0002298 UBERON:0005322 ! results in morphogenesis of mesonephric nephron creation_date: 2010-08-19T02:26:24Z [Term] id: GO:0061231 name: mesonephric glomerulus vasculature development namespace: biological_process def: "The biological process whose specific outcome is the progression of a mesonephric glomerulus vasculature from an initial condition to its mature state. This process begins with the formation of the mesonephric glomerulus vasculature and ends with the mature structure. The mesonephric glomerulus vasculature is composed of the tubule structures that carry blood or lymph in the mesonephric glomerulus." [GOC:mtg_kidney_jan10] is_a: GO:0072012 ! glomerulus vasculature development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0005326 ! results in development of mesonephric glomerulus vasculature relationship: BFO:0000050 GO:0061224 ! part of mesonephric glomerulus development relationship: RO:0002296 UBERON:0005326 ! results in development of mesonephric glomerulus vasculature creation_date: 2010-08-19T02:47:06Z [Term] id: GO:0061232 name: mesonephric glomerular epithelium development namespace: biological_process def: "The process whose specific outcome is the progression of the mesonephric glomerular epithelium over time, from its formation to the mature structure. The mesonephric glomerular epithelium is an epithelial tissue that covers the outer surfaces of the glomerulus in the mesonephros. The mesonephric glomerular epithelium consists of both parietal and visceral epithelium. Mesonephric glomerular parietal epithelial cells are specialized epithelial cells that form tight junctions as a barrier to protein transport. A mesonephric glomerular visceral epithelial cell is a specialized epithelial cell that contains 'feet' that interdigitate with the 'feet' of other glomerular epithelial cells in the mesonephros." [GOC:mtg_kidney_jan10] is_a: GO:0061241 ! mesonephric nephron epithelium development is_a: GO:0072010 ! glomerular epithelium development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0005327 ! results in development of mesonephric glomerular epithelium relationship: BFO:0000050 GO:0061224 ! part of mesonephric glomerulus development relationship: RO:0002296 UBERON:0005327 ! results in development of mesonephric glomerular epithelium creation_date: 2010-08-19T02:49:46Z [Term] id: GO:0061234 name: mesonephric glomerulus morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the mesonephric glomerulus are generated and organized. The mesonephric glomerulus is a capillary tuft surrounded by Bowman's capsule in nephrons of the vertebrate mesonephros." [GOC:mtg_kidney_jan10] is_a: GO:0072102 ! glomerulus morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0005325 ! results in morphogenesis of mesonephric glomerulus relationship: BFO:0000050 GO:0061224 ! part of mesonephric glomerulus development relationship: BFO:0000050 GO:0061228 ! part of mesonephric nephron morphogenesis relationship: RO:0002298 UBERON:0005325 ! results in morphogenesis of mesonephric glomerulus creation_date: 2010-08-19T02:53:35Z [Term] id: GO:0061235 name: mesenchymal stem cell maintenance involved in mesonephric nephron morphogenesis namespace: biological_process def: "The process in which an organism retains a population of mesenchymal stem cells that contributes to the shaping of a nephron in the mesonephros. A mesenchymal stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized mesenchymal cells." [GOC:mtg_kidney_jan10] is_a: GO:0072038 ! mesenchymal stem cell maintenance involved in nephron morphogenesis relationship: BFO:0000050 GO:0061228 ! part of mesonephric nephron morphogenesis creation_date: 2010-08-19T02:57:11Z [Term] id: GO:0061236 name: mesonephric comma-shaped body morphogenesis namespace: biological_process def: "The process in which the mesonephric comma-shaped body is generated and organized. The mesonephric comma-shaped body is the precursor structure to the mesonephric S-shaped body that contributes to the morphogenesis of a nephron in the mesonephros." [GOC:mtg_kidney_jan10] is_a: GO:0072049 ! comma-shaped body morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0005328 ! results in morphogenesis of mesonephric comma-shaped body relationship: BFO:0000050 GO:0061228 ! part of mesonephric nephron morphogenesis relationship: RO:0002298 UBERON:0005328 ! results in morphogenesis of mesonephric comma-shaped body creation_date: 2010-08-19T03:00:21Z [Term] id: GO:0061240 name: mesonephric nephron tubule morphogenesis namespace: biological_process def: "The process in which the anatomical structures of a mesonephric nephron tubule are generated and organized. A mesonephric nephron tubule is an epithelial tube that is part of the mesonephric nephron, the functional part of the mesonephros." [GOC:mtg_kidney_jan10] is_a: GO:0072171 ! mesonephric tubule morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0005329 ! results in morphogenesis of mesonephric nephron tubule relationship: BFO:0000050 GO:0061228 ! part of mesonephric nephron morphogenesis relationship: BFO:0000050 GO:0061242 ! part of mesonephric nephron tubule development relationship: RO:0002298 UBERON:0005329 ! results in morphogenesis of mesonephric nephron tubule creation_date: 2010-08-19T03:09:26Z [Term] id: GO:0061241 name: mesonephric nephron epithelium development namespace: biological_process def: "The process whose specific outcome is the progression of the mesonephric nephron epithelium over time, from its formation to the mature structure. An epithelium is a tissue that covers the internal or external surfaces of an anatomical structure. The mesonephric nephron epithelium is a tissue that covers the surface of a nephron in the mesonephros." [GOC:mtg_kidney_jan10] is_a: GO:0072009 ! nephron epithelium development is_a: GO:0072163 ! mesonephric epithelium development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0005330 ! results in development of mesonephric nephron epithelium relationship: BFO:0000050 GO:0061215 ! part of mesonephric nephron development relationship: RO:0002296 UBERON:0005330 ! results in development of mesonephric nephron epithelium creation_date: 2010-08-19T03:11:59Z [Term] id: GO:0061242 name: mesonephric nephron tubule development namespace: biological_process def: "The progression of a mesonephric nephron tubule over time, from its initial formation to the mature structure. A mesonephric nephron tubule is an epithelial tube that is part of the mesonephric nephron, the functional part of the mesonephros." [GOC:mtg_kidney_jan10] is_a: GO:0061241 ! mesonephric nephron epithelium development is_a: GO:0072080 ! nephron tubule development is_a: GO:0072164 ! mesonephric tubule development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0005329 ! results in development of mesonephric nephron tubule relationship: RO:0002296 UBERON:0005329 ! results in development of mesonephric nephron tubule creation_date: 2010-08-19T03:17:00Z [Term] id: GO:0061243 name: mesonephric renal vesicle morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the mesonephric renal vesicle are generated and organized. The renal vesicle is the primordial structure of the mesonephric nephron epithelium, and is formed by the condensation of mesenchymal cells." [GOC:mtg_kidney_jan10] is_a: GO:0072077 ! renal vesicle morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0005331 ! results in morphogenesis of mesonephric renal vesicle relationship: BFO:0000050 GO:0061228 ! part of mesonephric nephron morphogenesis relationship: RO:0002298 UBERON:0005331 ! results in morphogenesis of mesonephric renal vesicle creation_date: 2010-08-19T03:20:21Z [Term] id: GO:0061244 name: mesonephric S-shaped body morphogenesis namespace: biological_process def: "The process in which the mesonephric S-shaped body is generated and organized. The mesonephric S-shaped body is the successor of the mesonephric comma-shaped body that contributes to the morphogenesis of a nephron in the mesonephros." [GOC:mtg_kidney_jan10] is_a: GO:0072050 ! S-shaped body morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0005332 ! results in morphogenesis of mesonephric S-shaped body relationship: BFO:0000050 GO:0061228 ! part of mesonephric nephron morphogenesis relationship: RO:0002298 UBERON:0005332 ! results in morphogenesis of mesonephric S-shaped body creation_date: 2010-08-19T03:23:55Z [Term] id: GO:0061247 name: mesonephric glomerular mesangium development namespace: biological_process def: "The process whose specific outcome is the progression of the mesonephric glomerular mesangium over time, from its formation to the mature structure. The mesonephric glomerular mesangium is the thin membrane connective tissue composed of mesangial cells in the mesonephros, which helps to support the capillary loops in a renal glomerulus." [GOC:mtg_kidney_jan10] is_a: GO:0072109 ! glomerular mesangium development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0006182 ! results in development of mesonephric glomerular mesangium relationship: BFO:0000050 GO:0061231 ! part of mesonephric glomerulus vasculature development relationship: RO:0002296 UBERON:0006182 ! results in development of mesonephric glomerular mesangium creation_date: 2010-08-30T12:59:25Z [Term] id: GO:0061248 name: mesonephric glomerulus vasculature morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the mesonephric glomerulus vasculature are generated and organized. The mesonephric glomerulus vasculature is composed of the tubule structures that carry blood or lymph in the mesonephric glomerulus." [GOC:mtg_kidney_jan10] is_a: GO:0072103 ! glomerulus vasculature morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0005326 ! results in morphogenesis of mesonephric glomerulus vasculature relationship: BFO:0000050 GO:0061231 ! part of mesonephric glomerulus vasculature development relationship: BFO:0000050 GO:0061234 ! part of mesonephric glomerulus morphogenesis relationship: RO:0002298 UBERON:0005326 ! results in morphogenesis of mesonephric glomerulus vasculature creation_date: 2010-08-30T01:11:34Z [Term] id: GO:0061249 name: mesonephric glomerular capillary formation namespace: biological_process def: "The process that gives rise to a mesonephric glomerular capillary. This process pertains to the initial formation of a structure from unspecified parts." [GOC:mtg_kidney_jan10] is_a: GO:0072104 ! glomerular capillary formation intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0006183 ! results in formation of anatomical entity mesonephric glomerular capillary relationship: BFO:0000050 GO:0061248 ! part of mesonephric glomerulus vasculature morphogenesis relationship: RO:0002297 UBERON:0006183 ! results in formation of anatomical entity mesonephric glomerular capillary creation_date: 2010-08-30T01:17:08Z [Term] id: GO:0061250 name: mesonephric glomerular epithelial cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a mesonephric glomerular epithelial cell. Mesonephric glomerular epithelial cells are specialized epithelial cells that form part of the mesonephric glomerulus; there are two types, mesonephric glomerular parietal epithelial cells and mesonephric glomerular visceral epithelial cells." [GOC:mtg_kidney_jan10] is_a: GO:0061208 ! cell differentiation involved in mesonephros development is_a: GO:0072311 ! glomerular epithelial cell differentiation relationship: BFO:0000050 GO:0061232 ! part of mesonephric glomerular epithelium development creation_date: 2010-08-30T01:20:03Z [Term] id: GO:0061251 name: mesonephric glomerular epithelial cell development namespace: biological_process def: "The process whose specific outcome is the progression of a mesonephric glomerular epithelial cell over time, from its formation to the mature structure. Mesonephric glomerular epithelial cells are specialized epithelial cells that form part of the mesonephric glomerulus; there are two types, mesonephric glomerular parietal epithelial cells and mesonephric glomerular visceral epithelial cells." [GOC:mtg_kidney_jan10] is_a: GO:0072310 ! glomerular epithelial cell development relationship: BFO:0000050 GO:0061250 ! part of mesonephric glomerular epithelial cell differentiation creation_date: 2010-08-30T01:20:45Z [Term] id: GO:0061256 name: mesonephric podocyte differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a mesonephric glomerular visceral epithelial cell. A mesonephric glomerular visceral epithelial cell is a specialized epithelial cell that contains 'feet' that interdigitate with the 'feet' of other glomerular epithelial cells in the mesonephros." [GOC:mtg_kidney_jan10] synonym: "mesonephric glomerular visceral epithelial cell differentiation" EXACT [] is_a: GO:0061250 ! mesonephric glomerular epithelial cell differentiation is_a: GO:0072112 ! podocyte differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0002523 ! results in acquisition of features of mesonephric podocyte relationship: RO:0002315 CL:0002523 ! results in acquisition of features of mesonephric podocyte property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/23000" xsd:anyURI creation_date: 2010-08-30T02:03:38Z [Term] id: GO:0061257 name: mesonephric podocyte development namespace: biological_process def: "The process whose specific outcome is the progression of a mesonephric glomerular visceral epithelial cell over time, from its formation to the mature structure. A mesonephric glomerular visceral epithelial cell is a specialized epithelial cell that contains 'feet' that interdigitate with the 'feet' of other glomerular epithelial cells in the mesonephros." [GOC:mtg_kidney_jan10] synonym: "mesonephric glomerular visceral epithelial cell development" EXACT [] is_a: GO:0061251 ! mesonephric glomerular epithelial cell development is_a: GO:0072015 ! podocyte development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 CL:0002523 ! results in development of mesonephric podocyte relationship: BFO:0000050 GO:0061256 ! part of mesonephric podocyte differentiation relationship: RO:0002296 CL:0002523 ! results in development of mesonephric podocyte property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/23000" xsd:anyURI creation_date: 2010-08-30T02:10:40Z [Term] id: GO:0061261 name: mesenchymal to epithelial transition involved in mesonephros morphogenesis namespace: biological_process def: "A transition where a mesenchymal cell establishes apical/basolateral polarity, forms intercellular adhesive junctions, synthesizes basement membrane components and becomes an epithelial cell that will contribute to the shaping of the mesonephros." [GOC:mtg_kidney_jan10] synonym: "mesonephric mesenchyme to epithelial transition" RELATED [GOC:mtg_kidney_jan10] is_a: GO:0035850 ! epithelial cell differentiation involved in kidney development is_a: GO:0060231 ! mesenchymal to epithelial transition is_a: GO:0061208 ! cell differentiation involved in mesonephros development intersection_of: GO:0060231 ! mesenchymal to epithelial transition intersection_of: BFO:0000050 GO:0061206 ! part of mesonephros morphogenesis relationship: BFO:0000050 GO:0061206 ! part of mesonephros morphogenesis creation_date: 2010-08-30T02:35:15Z [Term] id: GO:0061262 name: mesonephric renal vesicle formation namespace: biological_process def: "The developmental process pertaining to the initial formation of the mesonephros." [GOC:mtg_kidney_jan10] synonym: "mesonephros formation" EXACT [GOC:mtg_kidney_jan10] is_a: GO:0072033 ! renal vesicle formation intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0005331 ! results in formation of anatomical entity mesonephric renal vesicle relationship: BFO:0000050 GO:0061243 ! part of mesonephric renal vesicle morphogenesis relationship: RO:0002297 UBERON:0005331 ! results in formation of anatomical entity mesonephric renal vesicle creation_date: 2010-08-30T02:41:20Z [Term] id: GO:0061265 name: mesonephric nephron tubule epithelial cell differentiation namespace: biological_process def: "The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the cells of the mesonephric nephron tubule as it progresses from its formation to the mature state." [GOC:mtg_kidney_jan10] is_a: GO:0061208 ! cell differentiation involved in mesonephros development is_a: GO:0072160 ! nephron tubule epithelial cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:1000022 ! results in acquisition of features of mesonephric nephron tubule epithelial cell relationship: BFO:0000050 GO:0061242 ! part of mesonephric nephron tubule development relationship: RO:0002315 CL:1000022 ! results in acquisition of features of mesonephric nephron tubule epithelial cell creation_date: 2010-08-30T03:02:09Z [Term] id: GO:0061271 name: mesenchymal to epithelial transition involved in mesonephric renal vesicle formation namespace: biological_process def: "A transition where a mesenchymal cell establishes apical/basolateral polarity,forms intercellular adhesive junctions, synthesizes basement membrane components and becomes an epithelial cell that will contribute to the shaping of the mesonephric renal vesicle." [GOC:mtg_kidney_jan10] is_a: GO:0061261 ! mesenchymal to epithelial transition involved in mesonephros morphogenesis is_a: GO:0072036 ! mesenchymal to epithelial transition involved in renal vesicle formation intersection_of: GO:0060231 ! mesenchymal to epithelial transition intersection_of: BFO:0000050 GO:0061262 ! part of mesonephric renal vesicle formation relationship: BFO:0000050 GO:0061262 ! part of mesonephric renal vesicle formation creation_date: 2010-08-30T03:26:30Z [Term] id: GO:0061272 name: mesonephric connecting tubule development namespace: biological_process def: "The process whose specific outcome is the progression of the mesonephric connecting tubule over time, from its formation to the mature structure. The mesonephric connecting tubule is a tubular segment of the mesonephric nephron; it connects the distal tubule to the collecting duct in the mesonephros." [GOC:mtg_kidney_jan10] synonym: "mesonephric collecting tubule development" EXACT [GOC:dph] synonym: "mesonephric connecting duct development" RELATED [GOC:mtg_kidney_jan10] is_a: GO:0061242 ! mesonephric nephron tubule development is_a: GO:0072027 ! connecting tubule development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0006189 ! results in development of mesonephric connecting tubule relationship: RO:0002296 UBERON:0006189 ! results in development of mesonephric connecting tubule creation_date: 2010-09-02T12:00:56Z [Term] id: GO:0061273 name: mesonephric distal tubule morphogenesis namespace: biological_process def: "The process in which the anatomical structures of a mesonephric distal tubule are generated and organized. The mesonephric distal tubule is a mesonephric nephron tubule that begins at the macula densa and extends to the mesonephric connecting tubule." [GOC:mtg_kidney_jan10] is_a: GO:0061240 ! mesonephric nephron tubule morphogenesis is_a: GO:0072156 ! distal tubule morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0006190 ! results in morphogenesis of mesonephric distal tubule relationship: BFO:0000050 GO:0061274 ! part of mesonephric distal tubule development relationship: RO:0002298 UBERON:0006190 ! results in morphogenesis of mesonephric distal tubule creation_date: 2010-09-02T12:12:00Z [Term] id: GO:0061274 name: mesonephric distal tubule development namespace: biological_process def: "The process whose specific outcome is the progression of the mesonephric distal tubule over time, from its formation to the mature structure. The mesonephric distal tubule is a mesonephric nephron tubule that begins at the terminal segment of the proximal tubule and ends at the mesonephric connecting tubule." [GOC:mtg_kidney_jan10] is_a: GO:0061242 ! mesonephric nephron tubule development is_a: GO:0072017 ! distal tubule development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0006190 ! results in development of mesonephric distal tubule relationship: RO:0002296 UBERON:0006190 ! results in development of mesonephric distal tubule creation_date: 2010-09-02T12:16:25Z [Term] id: GO:0061275 name: mesonephric proximal tubule development namespace: biological_process def: "The progression of the mesonephric proximal tubule over time, from its formation to the mature structure. The mesonephric proximal tubule extends from the capsule to the distal tubule." [GOC:mtg_kidney_jan10] is_a: GO:0061242 ! mesonephric nephron tubule development is_a: GO:0072014 ! proximal tubule development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0006192 ! results in development of mesonephric proximal tubule relationship: RO:0002296 UBERON:0006192 ! results in development of mesonephric proximal tubule creation_date: 2010-09-02T01:08:05Z [Term] id: GO:0061276 name: mesonephric proximal tubule morphogenesis namespace: biological_process def: "The process in which the anatomical structures of a mesonephric proximal tubule are generated and organized. The mesonephric proximal tubule extends from the capsule to the distal tubule." [GOC:mtg_kidney_jan10] is_a: GO:0061240 ! mesonephric nephron tubule morphogenesis is_a: GO:0072158 ! proximal tubule morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0006192 ! results in morphogenesis of mesonephric proximal tubule relationship: BFO:0000050 GO:0061275 ! part of mesonephric proximal tubule development relationship: RO:0002298 UBERON:0006192 ! results in morphogenesis of mesonephric proximal tubule creation_date: 2010-09-02T01:11:02Z [Term] id: GO:0061277 name: mesonephric nephron tubule formation namespace: biological_process def: "The developmental process pertaining to the initial formation of a mesonephric nephron tubule from unspecified parts. A mesonephric nephron tubule is an epithelial tube that is part of a nephron in the mesonephros." [GOC:mtg_kidney_jan10] is_a: GO:0072172 ! mesonephric tubule formation intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0005329 ! results in formation of anatomical entity mesonephric nephron tubule relationship: BFO:0000050 GO:0061240 ! part of mesonephric nephron tubule morphogenesis relationship: RO:0002297 UBERON:0005329 ! results in formation of anatomical entity mesonephric nephron tubule creation_date: 2010-09-02T01:16:21Z [Term] id: GO:0061278 name: epithelial cell migration involved in mesonephric nephron tubule morphogenesis namespace: biological_process def: "The orderly movement of epithelial cells within a renal tubule that contributes to mesonephric nephron tubule morphogenesis." [GOC:mtg_kidney_jan10] is_a: GO:0072155 ! epithelial cell migration involved in nephron tubule morphogenesis intersection_of: GO:0010631 ! epithelial cell migration intersection_of: BFO:0000050 GO:0061240 ! part of mesonephric nephron tubule morphogenesis relationship: BFO:0000050 GO:0061240 ! part of mesonephric nephron tubule morphogenesis creation_date: 2010-09-02T01:18:53Z [Term] id: GO:0061279 name: epithelial cell migration involved in mesonephric distal tubule morphogenesis namespace: biological_process def: "The orderly movement of epithelial cells within a renal tubule that contributes to mesonephric distal tubule morphogenesis." [GOC:mtg_kidney_jan10] is_a: GO:0061278 ! epithelial cell migration involved in mesonephric nephron tubule morphogenesis is_a: GO:0072157 ! epithelial cell migration involved in distal tubule morphogenesis intersection_of: GO:0010631 ! epithelial cell migration intersection_of: BFO:0000050 GO:0061273 ! part of mesonephric distal tubule morphogenesis relationship: BFO:0000050 GO:0061273 ! part of mesonephric distal tubule morphogenesis creation_date: 2010-09-02T01:20:56Z [Term] id: GO:0061280 name: epithelial cell migration involved in mesonephric proximal tubule morphogenesis namespace: biological_process def: "The orderly movement of epithelial cells within a renal tubule that contributes to mesonephric proximal tubule morphogenesis." [GOC:mtg_kidney_jan10] is_a: GO:0061278 ! epithelial cell migration involved in mesonephric nephron tubule morphogenesis is_a: GO:0072159 ! epithelial cell migration involved in proximal tubule morphogenesis intersection_of: GO:0010631 ! epithelial cell migration intersection_of: BFO:0000050 GO:0061276 ! part of mesonephric proximal tubule morphogenesis relationship: BFO:0000050 GO:0061276 ! part of mesonephric proximal tubule morphogenesis creation_date: 2010-09-02T01:23:43Z [Term] id: GO:0061285 name: mesonephric capsule development namespace: biological_process def: "The progression of the mesonephric capsule over time, from its formation to the mature structure. The mesonephric capsule is the tough fibrous layer surrounding the mesonephros, covered in a thick layer of perinephric adipose tissue." [GOC:mtg_kidney_jan10] is_a: GO:0072127 ! renal capsule development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0006170 ! results in development of mesonephric capsule relationship: BFO:0000050 GO:0001823 ! part of mesonephros development relationship: RO:0002296 UBERON:0006170 ! results in development of mesonephric capsule creation_date: 2010-09-02T01:50:06Z [Term] id: GO:0061286 name: mesonephric capsule morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the mesonephric capsule are generated and organized. The mesonephric capsule is the tough fibrous layer surrounding the mesonephros, covered in a thick layer of perinephric adipose tissue. It provides some protection from trauma and damage." [GOC:mtg_kidney_jan10] is_a: GO:0072128 ! renal capsule morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0006170 ! results in morphogenesis of mesonephric capsule relationship: BFO:0000050 GO:0061285 ! part of mesonephric capsule development relationship: RO:0002298 UBERON:0006170 ! results in morphogenesis of mesonephric capsule creation_date: 2010-09-02T01:53:31Z [Term] id: GO:0061287 name: mesonephric capsule formation namespace: biological_process def: "The developmental process pertaining to the initial formation of a mesonephric capsule from unspecified parts. The mesonephric capsule is the tough fibrous layer surrounding the mesonephros, covered in a thick layer of perinephric adipose tissue. It provides some protection from trauma and damage." [GOC:mtg_kidney_jan10] is_a: GO:0072129 ! renal capsule formation intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0006170 ! results in formation of anatomical entity mesonephric capsule relationship: BFO:0000050 GO:0061286 ! part of mesonephric capsule morphogenesis relationship: RO:0002297 UBERON:0006170 ! results in formation of anatomical entity mesonephric capsule creation_date: 2010-09-02T01:55:03Z [Term] id: GO:0061295 name: regulation of mesenchymal cell apoptotic process involved in mesonephric nephron morphogenesis namespace: biological_process def: "Any process that modulates the occurrence or rate of mesenchymal stem cell death by apoptotic process that contributes to the shaping of the nephron in the mesonephros." [GOC:mtg_apoptosis, GOC:mtg_kidney_jan10] synonym: "regulation of mesenchymal stem cell apoptosis involved in mesonephric nephron morphogenesis" NARROW [] synonym: "regulation of mesenchymal stem cell apoptotic process involved in mesonephric nephron morphogenesis" EXACT [] is_a: GO:0072039 ! regulation of mesenchymal cell apoptotic process involved in nephron morphogenesis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:1901146 ! regulates mesenchymal cell apoptotic process involved in mesonephric nephron morphogenesis relationship: RO:0002211 GO:0061235 ! regulates mesenchymal stem cell maintenance involved in mesonephric nephron morphogenesis relationship: RO:0002211 GO:1901146 ! regulates mesenchymal cell apoptotic process involved in mesonephric nephron morphogenesis creation_date: 2010-09-06T09:48:56Z [Term] id: GO:0061296 name: negative regulation of mesenchymal cell apoptotic process involved in mesonephric nephron morphogenesis namespace: biological_process def: "Any process that reduces the occurrence or rate of mesenchymal stem cell death by apoptotic process that contributes to the shaping of the nephron in the mesonephros." [GOC:mtg_apoptosis, GOC:mtg_kidney_jan10] synonym: "negative regulation of mesenchymal stem cell apoptosis involved in mesonephric nephron morphogenesis" NARROW [] synonym: "negative regulation of mesenchymal stem cell apoptotic process involved in mesonephric nephron morphogenesis" EXACT [] is_a: GO:0061218 ! negative regulation of mesonephros development is_a: GO:0061295 ! regulation of mesenchymal cell apoptotic process involved in mesonephric nephron morphogenesis is_a: GO:0072040 ! negative regulation of mesenchymal cell apoptotic process involved in nephron morphogenesis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:1901146 ! negatively regulates mesenchymal cell apoptotic process involved in mesonephric nephron morphogenesis relationship: RO:0002212 GO:0061235 ! negatively regulates mesenchymal stem cell maintenance involved in mesonephric nephron morphogenesis relationship: RO:0002212 GO:1901146 ! negatively regulates mesenchymal cell apoptotic process involved in mesonephric nephron morphogenesis creation_date: 2010-09-06T09:54:49Z [Term] id: GO:0061297 name: positive regulation of mesenchymal cell apoptotic process involved in mesonephric nephron morphogenesis namespace: biological_process def: "Any process that increases the occurrence or rate of mesenchymal stem cell death by apoptotic process that contributes to the shaping of the nephron in the mesonephros." [GOC:mtg_apoptosis, GOC:mtg_kidney_jan10] synonym: "positive regulation of mesenchymal stem cell apoptosis involved in mesonephric nephron morphogenesis" NARROW [] synonym: "positive regulation of mesenchymal stem cell apoptotic process involved in mesonephric nephron morphogenesis" EXACT [] is_a: GO:0061213 ! positive regulation of mesonephros development is_a: GO:0061295 ! regulation of mesenchymal cell apoptotic process involved in mesonephric nephron morphogenesis is_a: GO:0072041 ! positive regulation of mesenchymal cell apoptotic process involved in nephron morphogenesis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:1901146 ! positively regulates mesenchymal cell apoptotic process involved in mesonephric nephron morphogenesis relationship: RO:0002213 GO:0061235 ! positively regulates mesenchymal stem cell maintenance involved in mesonephric nephron morphogenesis relationship: RO:0002213 GO:1901146 ! positively regulates mesenchymal cell apoptotic process involved in mesonephric nephron morphogenesis creation_date: 2010-09-06T09:58:59Z [Term] id: GO:0061298 name: retina vasculature development in camera-type eye namespace: biological_process def: "The process whose specific outcome is the progression of the vasculature of the retina over time, from its formation to the mature structure." [GOC:BHF, GOC:dph] synonym: "retinal vasculature development" EXACT [GOC:dph] is_a: GO:0001944 ! vasculature development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0004864 ! results in development of vasculature of retina relationship: BFO:0000050 GO:0060041 ! part of retina development in camera-type eye relationship: RO:0002296 UBERON:0004864 ! results in development of vasculature of retina creation_date: 2010-09-06T03:27:06Z [Term] id: GO:0061299 name: retina vasculature morphogenesis in camera-type eye namespace: biological_process def: "The process in which the vasculature of the retina is generated and organized." [GOC:BHF, GOC:dph] synonym: "retinal vasculature morphogenesis" EXACT [GOC:dph] is_a: BFO:0000003 is_a: GO:0009653 ! anatomical structure morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0004864 ! results in morphogenesis of vasculature of retina relationship: BFO:0000050 GO:0061298 ! part of retina vasculature development in camera-type eye relationship: RO:0002298 UBERON:0004864 ! results in morphogenesis of vasculature of retina creation_date: 2010-09-06T03:28:25Z [Term] id: GO:0061300 name: cerebellum vasculature development namespace: biological_process def: "The process whose specific outcome is the progression of the vasculature of the cerebellum over time, from its formation to the mature structure." [GOC:dph] is_a: GO:0001944 ! vasculature development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0006694 ! results in development of cerebellum vasculature relationship: RO:0002296 UBERON:0006694 ! results in development of cerebellum vasculature creation_date: 2010-09-06T03:36:40Z [Term] id: GO:0061301 name: cerebellum vasculature morphogenesis namespace: biological_process def: "The process in which the vasculature of the cerebellum is generated and organized." [GOC:BHF, GOC:dph] is_a: BFO:0000003 is_a: GO:0009653 ! anatomical structure morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0006694 ! results in morphogenesis of cerebellum vasculature relationship: BFO:0000050 GO:0021549 ! part of cerebellum development relationship: BFO:0000050 GO:0061300 ! part of cerebellum vasculature development relationship: RO:0002298 UBERON:0006694 ! results in morphogenesis of cerebellum vasculature creation_date: 2010-09-06T03:38:05Z [Term] id: GO:0061303 name: cornea development in camera-type eye namespace: biological_process def: "The progression of the cornea over time, from its formation to the mature structure. The cornea is the transparent structure that covers the anterior of the eye." [GOC:dph] is_a: GO:0048856 ! anatomical structure development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0000964 ! results in development of cornea relationship: BFO:0000050 GO:0043010 ! part of camera-type eye development relationship: RO:0002296 UBERON:0000964 ! results in development of cornea creation_date: 2010-09-14T02:09:08Z [Term] id: GO:0061304 name: retinal blood vessel morphogenesis namespace: biological_process def: "The process whose specific outcome is the progression of a blood vessel of the retina over time, from its formation to the mature structure." [GOC:BHF, GOC:dph] is_a: GO:0048514 ! blood vessel morphogenesis is_a: GO:0061299 ! retina vasculature morphogenesis in camera-type eye intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0003501 ! results in morphogenesis of retina blood vessel relationship: RO:0002298 UBERON:0003501 ! results in morphogenesis of retina blood vessel creation_date: 2010-09-16T09:02:59Z [Term] id: GO:0061307 name: cardiac neural crest cell differentiation involved in heart development namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a cardiac neural crest cell that will migrate to the heart and contribute to its development. Cardiac neural crest cells are specialized cells that migrate toward the heart from the third, fourth and sixth pharyngeal arches." [GOC:dph, GOC:mtg_heart, PMID:19705442] is_a: GO:0014033 ! neural crest cell differentiation is_a: GO:0035051 ! cardiocyte differentiation intersection_of: GO:0014033 ! neural crest cell differentiation intersection_of: BFO:0000050 GO:0007507 ! part of heart development creation_date: 2010-09-23T08:50:56Z [Term] id: GO:0061308 name: cardiac neural crest cell development involved in heart development namespace: biological_process def: "The process aimed at the progression of a cardiac neural crest cell over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell that contributes to the development of the heart." [GOC:dph, GOC:mtg_heart] is_a: GO:0014032 ! neural crest cell development intersection_of: GO:0014032 ! neural crest cell development intersection_of: BFO:0000050 GO:0007507 ! part of heart development relationship: BFO:0000050 GO:0061307 ! part of cardiac neural crest cell differentiation involved in heart development creation_date: 2010-09-23T09:01:49Z [Term] id: GO:0061309 name: cardiac neural crest cell development involved in outflow tract morphogenesis namespace: biological_process def: "The process aimed at the progression of a cardiac neural crest cell over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell that contributes to the shaping of the outflow tract." [GOC:dph, GOC:mtg_heart] is_a: GO:0061308 ! cardiac neural crest cell development involved in heart development intersection_of: GO:0014032 ! neural crest cell development intersection_of: BFO:0000050 GO:0003151 ! part of outflow tract morphogenesis relationship: BFO:0000050 GO:0003151 ! part of outflow tract morphogenesis creation_date: 2010-09-23T09:08:37Z [Term] id: GO:0061311 name: cell surface receptor signaling pathway involved in heart development namespace: biological_process def: "The series of molecular signals initiated by a ligand the binding to its receptor on the surface of a cell, which contributes to the progression of the heart over time." [GOC:dph, GOC:mtg_heart, GOC:signaling] synonym: "cell surface receptor linked signaling pathway involved in heart development" EXACT [GOC:bf] synonym: "cell surface receptor linked signalling pathway involved in heart development" EXACT [GOC:mah] is_a: GO:0007166 ! cell surface receptor signaling pathway intersection_of: GO:0007166 ! cell surface receptor signaling pathway intersection_of: BFO:0000050 GO:0007507 ! part of heart development relationship: BFO:0000050 GO:0007507 ! part of heart development creation_date: 2010-09-23T09:18:32Z [Term] id: GO:0061318 name: renal filtration cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized structural and/or functional features of a renal filtration cell. Renal filtration cells are specialized cells of the renal system that filter fluids by charge, size or both. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [GOC:dph, GOC:mtg_kidney_jan10] is_a: GO:0030154 ! cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0002522 ! results in acquisition of features of renal filtration cell relationship: BFO:0000050 GO:0072001 ! part of renal system development relationship: RO:0002315 CL:0002522 ! results in acquisition of features of renal filtration cell creation_date: 2010-09-24T12:18:35Z [Term] id: GO:0061319 name: nephrocyte differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of a nephrocyte. A nephrocyte is an insect renal cell that filters hemolymph. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [CL:0002520, GOC:dph, GOC:mtg_kidney_jan10, PMID:19783135] is_a: GO:0061318 ! renal filtration cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0002520 ! results in acquisition of features of nephrocyte relationship: RO:0002315 CL:0002520 ! results in acquisition of features of nephrocyte creation_date: 2010-09-24T12:23:29Z [Term] id: GO:0061320 name: pericardial nephrocyte differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of a pericardial nephrocyte. A pericardial nephrocyte is an insect renal cell that filters hemolymph and is found with other pericardial nephrocytes in two rows flanking the dorsal vessel. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [CL:0000474, GOC:dph, GOC:mtg_kidney_jan10, GOC:sart, PMID:19783135] synonym: "pericardial cell differentiation" NARROW [] is_a: GO:0061319 ! nephrocyte differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000474 ! results in acquisition of features of pericardial nephrocyte relationship: RO:0002315 CL:0000474 ! results in acquisition of features of pericardial nephrocyte creation_date: 2010-09-24T12:25:53Z [Term] id: GO:0061321 name: garland nephrocyte differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of a garland nephrocyte. A garland nephrocyte is an insect renal cell that filters hemolymph and forms a ring with other garland nephrocytes around the esophagus. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [CL:0000486, GOC:dph, GOC:mtg_kidney_jan10, GOC:sart, PMID:19783135] synonym: "garland cell differentiation" EXACT [] is_a: GO:0061319 ! nephrocyte differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000486 ! results in acquisition of features of garland cell relationship: BFO:0000050 GO:0001700 ! part of embryonic development via the syncytial blastoderm relationship: RO:0002315 CL:0000486 ! results in acquisition of features of garland cell creation_date: 2010-09-24T12:28:16Z [Term] id: GO:0061322 name: disseminated nephrocyte differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of a disseminated nephrocyte. A disseminated nephrocyte is an insect renal cell that filters hemolymph and is found at scattered locations in the fat body or other tissues. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [CL:0002524, GOC:19783135, GOC:dph, GOC:mtg_kidney_jan10] is_a: GO:0061319 ! nephrocyte differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0002524 ! results in acquisition of features of disseminated nephrocyte relationship: RO:0002315 CL:0002524 ! results in acquisition of features of disseminated nephrocyte creation_date: 2010-09-24T12:30:46Z [Term] id: GO:0061323 name: cell proliferation involved in heart morphogenesis namespace: biological_process def: "The multiplication or reproduction of cells, resulting in the expansion of a cell population that contributes to the shaping of the heart." [GOC:dph, GOC:mtg_heart] is_a: GO:0008283 ! cell population proliferation intersection_of: GO:0008283 ! cell population proliferation intersection_of: BFO:0000050 GO:0003007 ! part of heart morphogenesis relationship: BFO:0000050 GO:0003007 ! part of heart morphogenesis creation_date: 2010-09-28T09:05:26Z [Term] id: GO:0061325 name: cell proliferation involved in outflow tract morphogenesis namespace: biological_process def: "The multiplication or reproduction of cells, resulting in the expansion of a cell population that contributes to the shaping of the outflow tract." [GOC:dph, GOC:mtg_heart] is_a: GO:0061323 ! cell proliferation involved in heart morphogenesis intersection_of: GO:0008283 ! cell population proliferation intersection_of: BFO:0000050 GO:0003151 ! part of outflow tract morphogenesis relationship: BFO:0000050 GO:0003151 ! part of outflow tract morphogenesis creation_date: 2010-09-28T09:29:30Z [Term] id: GO:0061326 name: renal tubule development namespace: biological_process def: "The progression of the renal tubule over time from its formation to the mature form. A renal tubule is a tube that filters, re-absorbs and secretes substances to rid an organism of waste and to play a role in fluid homeostasis." [GOC:dph, GOC:mtg_kidney_jan10] is_a: GO:0035295 ! tube development is_a: GO:0060429 ! epithelium development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0009773 ! results in development of renal tubule relationship: BFO:0000050 GO:0072001 ! part of renal system development relationship: RO:0002296 UBERON:0009773 ! results in development of renal tubule creation_date: 2010-09-28T12:50:43Z [Term] id: GO:0061330 name: Malpighian tubule stellate cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a Malpighian tubule stellate cell. A Malpighian tubule stellate cell is a specialized epithelial secretory cell that moves chloride ions and water across the tubule epithelium." [GOC:dph, GOC:mtg_kidney_jan10, PMID:19783135] is_a: GO:0030855 ! epithelial cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:1000155 ! results in acquisition of features of Malpighian tubule stellate cell relationship: BFO:0000050 GO:0072002 ! part of Malpighian tubule development relationship: RO:0002315 CL:1000155 ! results in acquisition of features of Malpighian tubule stellate cell creation_date: 2010-09-28T01:32:55Z [Term] id: GO:0061331 name: epithelial cell proliferation involved in Malpighian tubule morphogenesis namespace: biological_process def: "The multiplication or reproduction of epithelial cells, resulting in the expansion of a cell population and contributing to the shaping of a Malpighian tubule." [GOC:dph, GOC:mtg_kidney_jan10, PMID:19783135] is_a: GO:2001013 ! epithelial cell proliferation involved in renal tubule morphogenesis intersection_of: GO:0050673 ! epithelial cell proliferation intersection_of: BFO:0000050 GO:0007443 ! part of Malpighian tubule morphogenesis relationship: BFO:0000050 GO:0007443 ! part of Malpighian tubule morphogenesis creation_date: 2010-09-28T02:01:02Z [Term] id: GO:0061332 name: Malpighian tubule bud morphogenesis namespace: biological_process def: "The morphogenetic process in which a bud forms from the embryonic hindgut tube to form the Malpighian tubule. A bud is a protrusion that forms from the tube by localized changes in cell shape and position." [GOC:dph, GOC:mtg_kidney_jan10, PMID:19783135] synonym: "Malpighian tubule formation" EXACT [GOC:dph] is_a: GO:0060572 ! morphogenesis of an epithelial bud is_a: GO:0072175 ! epithelial tube formation intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0001054 ! results in formation of anatomical entity Malpighian tubule relationship: BFO:0000050 GO:0007443 ! part of Malpighian tubule morphogenesis relationship: RO:0002297 UBERON:0001054 ! results in formation of anatomical entity Malpighian tubule creation_date: 2010-09-28T01:39:32Z [Term] id: GO:0061333 name: renal tubule morphogenesis namespace: biological_process def: "The process in which the renal tubule is generated by specification of cell fate, through the maintenance of cell polarity, regulated cell proliferation and morphogenetic cell rearrangements, shape changes and growth. A renal tubule is a tube that filters, re-absorbs and secretes substances to rid an organism of waste and to play a role in fluid homeostasis." [GOC:dph, GOC:mtg_kidney_jan10] is_a: GO:0060562 ! epithelial tube morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0009773 ! results in morphogenesis of renal tubule relationship: BFO:0000050 GO:0061326 ! part of renal tubule development relationship: RO:0002298 UBERON:0009773 ! results in morphogenesis of renal tubule creation_date: 2010-09-28T01:43:04Z [Term] id: GO:0061334 name: cell rearrangement involved in Malpighian tubule morphogenesis namespace: biological_process def: "The movement of an epithelial cell with respect to other epithelial cells that contributes to the shaping of the Malpighian tubule." [GOC:dph, GOC:mtg_kidney_jan10] synonym: "cell migration involved in Malpighian tubule morphogenesis" EXACT [] is_a: GO:0016477 ! cell migration intersection_of: GO:0016477 ! cell migration intersection_of: BFO:0000050 GO:0007443 ! part of Malpighian tubule morphogenesis relationship: BFO:0000050 GO:0007443 ! part of Malpighian tubule morphogenesis creation_date: 2010-09-28T02:04:05Z [Term] id: GO:0061335 name: cell growth involved in Malpighian tubule morphogenesis namespace: biological_process def: "The growth of an epithelial cell dependent on cycles of endoreplication, where growth contributes to the shaping of the Malpighian tubule." [GOC:dph, GOC:mtg_kidney_jan10, PMID:19783135] is_a: GO:0048588 ! developmental cell growth is_a: GO:0060560 ! developmental growth involved in morphogenesis intersection_of: GO:0048588 ! developmental cell growth intersection_of: BFO:0000050 GO:0007443 ! part of Malpighian tubule morphogenesis relationship: BFO:0000050 GO:0007443 ! part of Malpighian tubule morphogenesis creation_date: 2010-09-28T02:08:25Z [Term] id: GO:0061336 name: cell morphogenesis involved in Malpighian tubule morphogenesis namespace: biological_process def: "The shape change of an epithelial cell from a columnar to squamous cell morphology that contributes to the shaping of the Malpighian tubule." [GOC:dph, GOC:mtg_kidney_jan10, PMID:19783135] is_a: GO:0000902 ! cell morphogenesis intersection_of: GO:0000902 ! cell morphogenesis intersection_of: BFO:0000050 GO:0007443 ! part of Malpighian tubule morphogenesis relationship: BFO:0000050 GO:0007443 ! part of Malpighian tubule morphogenesis creation_date: 2010-09-28T02:11:47Z [Term] id: GO:0061337 name: cardiac conduction namespace: biological_process def: "Transfer of an organized electrical impulse across the heart to coordinate the contraction of cardiac muscles. The process begins with generation of an action potential (in the sinoatrial node (SA) in humans) and ends with a change in the rate, frequency, or extent of the contraction of the heart muscles." [GOC:dph] xref: Reactome:R-HSA-5576891 "Cardiac conduction" is_a: GO:0008016 ! regulation of heart contraction property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 creation_date: 2010-09-29T08:46:05Z [Term] id: GO:0061343 name: cell adhesion involved in heart morphogenesis namespace: biological_process def: "The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules that contributes to the shaping of the heart." [GOC:dph, GOC:mtg_heart, PMID:16860783] is_a: GO:0007155 ! cell adhesion intersection_of: GO:0007155 ! cell adhesion intersection_of: BFO:0000050 GO:0003007 ! part of heart morphogenesis relationship: BFO:0000050 GO:0003007 ! part of heart morphogenesis creation_date: 2010-09-29T11:34:06Z [Term] id: GO:0061344 name: regulation of cell adhesion involved in heart morphogenesis namespace: biological_process def: "Any process that modulates the extent of cell adhesion contributing to the shaping of the heart." [GOC:dph, GOC:mtg_heart, PMID:16860783] is_a: GO:0030155 ! regulation of cell adhesion intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0061343 ! regulates cell adhesion involved in heart morphogenesis relationship: RO:0002211 GO:0061343 ! regulates cell adhesion involved in heart morphogenesis creation_date: 2010-09-29T11:35:27Z [Term] id: GO:0061351 name: neural precursor cell proliferation namespace: biological_process def: "The multiplication or reproduction of neural precursor cells, resulting in the expansion of a cell population. A neural precursor cell is either a nervous system stem cell or a nervous system progenitor cell." [GOC:dph, GOC:yaf] is_a: GO:0008283 ! cell population proliferation property_value: RO:0002161 NCBITaxon:4751 creation_date: 2010-10-01T11:06:04Z [Term] id: GO:0061352 name: cell chemotaxis involved in Malpighian tubule morphogenesis namespace: biological_process def: "The directed movement of the outgrowing Malpighian tubule guided by specific chemical cues/signals. Movement may be towards a guidance cue (positive chemotaxis) or away from it (negative chemotaxis). Guidance contributes to the final positioning of the tubule." [GOC:dph, GOC:mtg_kidney_jan10] is_a: GO:0060326 ! cell chemotaxis is_a: GO:0061334 ! cell rearrangement involved in Malpighian tubule morphogenesis intersection_of: GO:0060326 ! cell chemotaxis intersection_of: BFO:0000050 GO:0007443 ! part of Malpighian tubule morphogenesis creation_date: 2010-10-01T11:57:28Z [Term] id: GO:0061360 name: optic chiasma development namespace: biological_process def: "The developmental process pertaining to the progression of the optic chiasm from its initial formation to the mature structure. The process begins when the pathfinding of the axons of the developing optic nerve cause some axons to cross at the midline of the brain and ends when the axons are mature." [GOC:dph] synonym: "optic chiasm development" EXACT [GOC:dph] is_a: GO:0048856 ! anatomical structure development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0000959 ! results in development of optic chiasma relationship: BFO:0000050 GO:0021554 ! part of optic nerve development relationship: RO:0002296 UBERON:0000959 ! results in development of optic chiasma creation_date: 2010-10-13T08:00:29Z [Term] id: GO:0061370 name: testosterone biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of testosterone, an androgen having 17beta-hydroxy and 3-oxo groups, together with unsaturation at C-4 C-5." [GOC:dph, GOC:yaf] is_a: GO:0006694 ! steroid biosynthetic process is_a: GO:0042181 ! ketone biosynthetic process is_a: GO:0120255 ! olefinic compound biosynthetic process intersection_of: GO:0009058 ! biosynthetic process intersection_of: RO:0004008 CHEBI:17347 ! has primary output relationship: RO:0004008 CHEBI:17347 ! has primary output creation_date: 2010-10-27T02:50:48Z [Term] id: GO:0061377 name: mammary gland lobule development namespace: biological_process def: "The progression of the mammary gland lobule over time, from its formation to the mature structure. A mammary gland lobule is a small rounded projection of the mammary gland." [GOC:dph, GOC:yaf] is_a: GO:0048856 ! anatomical structure development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0001912 ! results in development of lobule of mammary gland relationship: BFO:0000050 GO:0030879 ! part of mammary gland development relationship: RO:0002296 UBERON:0001912 ! results in development of lobule of mammary gland creation_date: 2010-11-09T09:36:29Z [Term] id: GO:0061382 name: Malpighian tubule tip cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a Malpighian tubule tip cell. A Malpighian tubule tip cell is a mitogenic signaling cell that controls the proliferation of its neighboring cells." [GOC:dph, GOC:mtg_kidney_jan10, PMID:7821213] is_a: GO:0030154 ! cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:1000182 ! results in acquisition of features of malpighian tubule tip cell relationship: BFO:0000050 GO:0072002 ! part of Malpighian tubule development relationship: RO:0002315 CL:1000182 ! results in acquisition of features of malpighian tubule tip cell creation_date: 2010-11-23T09:52:44Z [Term] id: GO:0061383 name: trabecula morphogenesis namespace: biological_process def: "The process of shaping a trabecula in an organ. A trabecula is a small, often microscopic, tissue element in the form of a small beam, strut or rod, which generally has a mechanical function. Trabecula are usually but not necessarily, composed of dense collagenous tissue." [GOC:dph] is_a: BFO:0000003 is_a: GO:0009653 ! anatomical structure morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0000440 ! results in morphogenesis of trabecula relationship: RO:0002298 UBERON:0000440 ! results in morphogenesis of trabecula creation_date: 2010-12-02T08:51:45Z [Term] id: GO:0061384 name: heart trabecula morphogenesis namespace: biological_process def: "The process of shaping a trabecula in the heart. A trabecula is a small, often microscopic, tissue element in the form of a small beam, strut or rod, which generally has a mechanical function. Trabecula are usually but not necessarily, composed of dense collagenous tissue." [GOC:dph] is_a: GO:0061383 ! trabecula morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0002511 ! results in morphogenesis of trabecula carnea relationship: RO:0002298 UBERON:0002511 ! results in morphogenesis of trabecula carnea creation_date: 2010-12-02T08:54:20Z [Term] id: GO:0061385 name: fibroblast proliferation involved in heart morphogenesis namespace: biological_process def: "The multiplication or reproduction of fibroblasts, resulting in the expansion of a fibroblast population that contributes to the shaping of the heart." [GOC:dph] is_a: GO:0048144 ! fibroblast proliferation is_a: GO:0061323 ! cell proliferation involved in heart morphogenesis intersection_of: GO:0048144 ! fibroblast proliferation intersection_of: BFO:0000050 GO:0003007 ! part of heart morphogenesis creation_date: 2011-02-10T01:41:59Z [Term] id: GO:0061437 name: renal system vasculature development namespace: biological_process def: "The process whose specific outcome is the progression of vasculature of the renal system over time, from its formation to the mature structure." [GOC:dph, GOC:mtg_kidney_jan10, PMID:11891195] is_a: GO:0001944 ! vasculature development relationship: BFO:0000050 GO:0072001 ! part of renal system development creation_date: 2012-03-08T12:16:24Z [Term] id: GO:0061438 name: renal system vasculature morphogenesis namespace: biological_process def: "The process in which the renal system vasculature is generated and organized. Morphogenesis pertains to the creation of form." [GOC:dph, GOC:mtg_kidney_jan10, PMID:11891195] is_a: GO:0009653 ! anatomical structure morphogenesis relationship: BFO:0000050 GO:0061437 ! part of renal system vasculature development creation_date: 2012-03-08T12:21:56Z [Term] id: GO:0061439 name: kidney vasculature morphogenesis namespace: biological_process def: "The process in which the kidney vasculature is generated and organized. Morphogenesis pertains to the creation of form." [GOC:dph, GOC:mtg_kidney_jan10] is_a: BFO:0000003 is_a: GO:0009653 ! anatomical structure morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0006544 ! results in morphogenesis of kidney vasculature relationship: BFO:0000050 GO:0061438 ! part of renal system vasculature morphogenesis relationship: BFO:0000050 GO:0061440 ! part of kidney vasculature development relationship: RO:0002298 UBERON:0006544 ! results in morphogenesis of kidney vasculature creation_date: 2012-03-08T12:30:11Z [Term] id: GO:0061440 name: kidney vasculature development namespace: biological_process def: "The process whose specific outcome is the progression of the vasculature of the kidney over time, from its formation to the mature structure." [GOC:dph, GOC:mtg_kidney_jan10, PMID:11891195] is_a: GO:0061437 ! renal system vasculature development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0006544 ! results in development of kidney vasculature relationship: BFO:0000050 GO:0001822 ! part of kidney development relationship: RO:0002296 UBERON:0006544 ! results in development of kidney vasculature creation_date: 2012-03-08T12:39:09Z [Term] id: GO:0061441 name: renal artery morphogenesis namespace: biological_process def: "The process in which the anatomical structure of a renal artery is generated and organized. Renal arteries supply the kidneys with blood." [GOC:mtg_kidney_jan10, PMID:11891195] is_a: GO:0048844 ! artery morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0001184 ! results in morphogenesis of renal artery relationship: BFO:0000050 GO:0061439 ! part of kidney vasculature morphogenesis relationship: RO:0002298 UBERON:0001184 ! results in morphogenesis of renal artery creation_date: 2012-03-08T12:42:09Z [Term] id: GO:0061448 name: connective tissue development namespace: biological_process def: "The progression of a connective tissue over time, from its formation to the mature structure." [GOC:BHF] is_a: GO:0009888 ! tissue development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0002384 ! results in development of connective tissue relationship: RO:0002296 UBERON:0002384 ! results in development of connective tissue creation_date: 2012-03-22T12:53:41Z [Term] id: GO:0061449 name: olfactory bulb tufted cell development namespace: biological_process def: "The process whose specific outcome is the progression of an olfactory bulb tufted cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell." [GOC:dph] is_a: GO:0021884 ! forebrain neuron development intersection_of: GO:0048468 ! cell development intersection_of: RO:0002296 CL:1001503 ! results in development of olfactory bulb tufted cell relationship: BFO:0000050 GO:0021772 ! part of olfactory bulb development relationship: RO:0002296 CL:1001503 ! results in development of olfactory bulb tufted cell creation_date: 2012-05-15T12:30:21Z [Term] id: GO:0061450 name: trophoblast cell migration namespace: biological_process def: "Trophoblast cell migration that is accomplished by extension and retraction of a pseudopodium. Trophoblast cells line the outside of the blastocyst." [GOC:dph] is_a: BFO:0000003 is_a: GO:0001667 ! ameboidal-type cell migration intersection_of: GO:0016477 ! cell migration intersection_of: RO:0002565 CL:0000351 ! results in movement of trophoblast cell relationship: BFO:0000050 GO:0007566 ! part of embryo implantation relationship: RO:0002565 CL:0000351 ! results in movement of trophoblast cell creation_date: 2012-07-10T08:38:37Z [Term] id: GO:0061451 name: retrotrapezoid nucleus development namespace: biological_process def: "The progression of the retrotrapezoid nucleus (RTN) over time from it's initial formation to its mature state. The retrotrapezoid nucleus is a group of neurons in the rostral medulla, which are responsible regulating respiration." [GOC:dph] is_a: GO:0048857 ! neural nucleus development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0009918 ! results in development of retrotrapezoid nucleus relationship: BFO:0000050 GO:0021550 ! part of medulla oblongata development relationship: RO:0002296 UBERON:0009918 ! results in development of retrotrapezoid nucleus creation_date: 2012-07-19T12:38:30Z [Term] id: GO:0061452 name: retrotrapezoid nucleus neuron differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a neuron whose cell body resides in the retrotrapezoid nucleus." [GOC:dph] is_a: GO:0021953 ! central nervous system neuron differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:1000001 ! results in acquisition of features of retrotrapezoid nucleus neuron relationship: BFO:0000050 GO:0061451 ! part of retrotrapezoid nucleus development relationship: RO:0002315 CL:1000001 ! results in acquisition of features of retrotrapezoid nucleus neuron creation_date: 2012-07-19T12:43:18Z [Term] id: GO:0061453 name: interstitial cell of Cajal differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of an interstitial cell of Cajal. An interstitial cell of Cajal is an intestinal neuroepithelial cell that serves as a pacemaker to trigger gut contraction." [GOC:dph] synonym: "ICC differentiation" RELATED [GOC:dph] is_a: GO:0060563 ! neuroepithelial cell differentiation is_a: GO:0060575 ! intestinal epithelial cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0002088 ! results in acquisition of features of interstitial cell of Cajal relationship: RO:0002315 CL:0002088 ! results in acquisition of features of interstitial cell of Cajal creation_date: 2012-07-20T08:20:50Z [Term] id: GO:0061454 name: release of sequestered calcium ion into cytosol by Golgi namespace: biological_process def: "The directed movement of calcium ions (Ca2+) out of the Golgi apparatus into the cytosol." [GOC:dph, GOC:tb] synonym: "Golgi calcium ion export" BROAD [] is_a: GO:0051209 ! release of sequestered calcium ion into cytosol is_a: GO:0061856 ! Golgi calcium ion transmembrane transport intersection_of: GO:0055085 ! transmembrane transport intersection_of: RO:0002338 GO:0005794 ! has target start location Golgi apparatus intersection_of: RO:0002339 GO:0005829 ! has target end location cytosol intersection_of: RO:0004009 CHEBI:29108 ! has primary input relationship: RO:0002338 GO:0005794 ! has target start location Golgi apparatus creation_date: 2012-07-27T02:29:43Z [Term] id: GO:0061458 name: reproductive system development namespace: biological_process def: "The progression of the reproductive system over time from its formation to the mature structure. The reproductive system consists of the organs that function in reproduction." [GOC:dph] is_a: GO:0048731 ! system development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0000990 ! results in development of reproductive system relationship: RO:0002296 UBERON:0000990 ! results in development of reproductive system property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 creation_date: 2012-08-22T17:47:53Z [Term] id: GO:0061462 name: protein localization to lysosome namespace: biological_process def: "A process in which a protein is transported to, or maintained in, a location within a lysosome." [GOC:dph] is_a: GO:0072665 ! protein localization to vacuole intersection_of: GO:0008104 ! intracellular protein localization intersection_of: RO:0002339 GO:0005764 ! has target end location lysosome relationship: RO:0002339 GO:0005764 ! has target end location lysosome creation_date: 2012-10-05T10:50:51Z [Term] id: GO:0061469 name: regulation of type B pancreatic cell proliferation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of type B pancreatic cell proliferation." [GOC:dph] is_a: GO:0050678 ! regulation of epithelial cell proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0044342 ! regulates type B pancreatic cell proliferation relationship: RO:0002211 GO:0044342 ! regulates type B pancreatic cell proliferation property_value: RO:0002161 NCBITaxon:4751 creation_date: 2012-11-01T13:16:23Z [Term] id: GO:0061470 name: T follicular helper cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized T cell acquires specialized features of a mature T follicular helper cell." [GOC:dph, PMID:21572431] synonym: "T-helper follicular cell differentiation" EXACT [GOC:dph] is_a: GO:0042093 ! T-helper cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0002038 ! results in acquisition of features of T follicular helper cell relationship: RO:0002315 CL:0002038 ! results in acquisition of features of T follicular helper cell creation_date: 2012-11-02T09:01:48Z [Term] id: GO:0061484 name: hematopoietic stem cell homeostasis namespace: biological_process def: "Any biological process involved in the maintenance of the steady-state number of hematopoietic stem cells within a population of cells." [GOC:dph, PMID:21508411] is_a: BFO:0000003 is_a: GO:0048872 ! homeostasis of number of cells intersection_of: GO:0048872 ! homeostasis of number of cells intersection_of: RO:0012003 CL:0000037 ! acts on population of hematopoietic stem cell relationship: RO:0012003 CL:0000037 ! acts on population of hematopoietic stem cell property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 creation_date: 2012-12-04T09:41:02Z [Term] id: GO:0061485 name: memory T cell proliferation namespace: biological_process def: "The expansion of a memory T cell population by cell division." [GOC:dph, PMID:14647273] is_a: GO:0042098 ! T cell proliferation intersection_of: GO:0008283 ! cell population proliferation intersection_of: RO:0012003 CL:0000813 ! acts on population of memory T cell relationship: RO:0012003 CL:0000813 ! acts on population of memory T cell creation_date: 2012-12-04T09:52:54Z [Term] id: GO:0061512 name: protein localization to cilium namespace: biological_process def: "A process in which a protein is transported to, or maintained in, a location within a cilium." [GOC:dph] is_a: GO:0033365 ! protein localization to organelle intersection_of: GO:0008104 ! intracellular protein localization intersection_of: RO:0002339 GO:0005929 ! has target end location cilium relationship: RO:0002162 NCBITaxon:2759 ! in taxon Eukaryota relationship: RO:0002339 GO:0005929 ! has target end location cilium property_value: RO:0002161 NCBITaxon:3176 property_value: RO:0002161 NCBITaxon:3378 property_value: RO:0002161 NCBITaxon:3398 property_value: RO:0002161 NCBITaxon:4890 property_value: RO:0002161 NCBITaxon:5782 creation_date: 2013-03-22T15:41:44Z [Term] id: GO:0061515 name: myeloid cell development namespace: biological_process def: "The process whose specific outcome is the progression of a myeloid cell over time, from its formation to the mature structure." [GOC:dph] is_a: GO:0030097 ! hemopoiesis intersection_of: GO:0048468 ! cell development intersection_of: RO:0002296 CL:0000763 ! results in development of myeloid cell relationship: BFO:0000050 GO:0030099 ! part of myeloid cell differentiation relationship: RO:0002296 CL:0000763 ! results in development of myeloid cell creation_date: 2013-04-18T13:03:16Z [Term] id: GO:0061519 name: macrophage homeostasis namespace: biological_process def: "The process of regulating the proliferation and elimination of macrophage cells such that the total number of myeloid cells within a whole or part of an organism is stable over time in the absence of an outside stimulus." [GOC:dph, PMID:21727904] is_a: GO:0001776 ! leukocyte homeostasis is_a: GO:0002262 ! myeloid cell homeostasis intersection_of: GO:0048872 ! homeostasis of number of cells intersection_of: RO:0012003 CL:0000235 ! acts on population of macrophage relationship: RO:0012003 CL:0000235 ! acts on population of macrophage creation_date: 2013-04-18T13:25:33Z [Term] id: GO:0061520 name: Langerhans cell differentiation namespace: biological_process def: "The process in which a precursor cell type acquires the specialized features of a Langerhans cell." [GOC:dph, PMID:22729249] is_a: GO:0043011 ! myeloid dendritic cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000453 ! results in acquisition of features of Langerhans cell relationship: RO:0002315 CL:0000453 ! results in acquisition of features of Langerhans cell creation_date: 2013-04-18T13:29:07Z [Term] id: GO:0061521 name: hepatic stellate cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of a hepatic stellate cell." [GOC:dph, PMID:9407545] is_a: GO:0030154 ! cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000632 ! results in acquisition of features of hepatic stellate cell relationship: RO:0002315 CL:0000632 ! results in acquisition of features of hepatic stellate cell creation_date: 2013-04-18T13:36:08Z [Term] id: GO:0061523 name: cilium disassembly namespace: biological_process def: "A cellular process that results in the breakdown of a cilium." [GOC:cilia, GOC:dph, PMID:17604723, PMID:27350441] comment: Note that we deem cilium and microtubule-based flagellum to be equivalent. synonym: "cilium resorption" EXACT [GOC:dph] is_a: GO:0044782 ! cilium organization is_a: GO:1903008 ! organelle disassembly intersection_of: GO:0022411 ! cellular component disassembly intersection_of: RO:0002590 GO:0005929 ! results in disassembly of cilium relationship: RO:0002590 GO:0005929 ! results in disassembly of cilium creation_date: 2013-04-18T14:59:59Z [Term] id: GO:0061524 name: central canal development namespace: biological_process def: "The process whose specific outcome is the formation of the central canal of the spinal cord from its formation to the mature structure. The central canal is a spinal cord structure that is part of the ventricular system and is filled with cerebral-spinal fluid and runs the length of the spinal cord." [GOC:cvs, GOC:dph, PMID:23409159] is_a: GO:0048856 ! anatomical structure development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0002291 ! results in development of central canal of spinal cord relationship: BFO:0000050 GO:0021510 ! part of spinal cord development relationship: RO:0002296 UBERON:0002291 ! results in development of central canal of spinal cord creation_date: 2013-04-20T08:18:31Z [Term] id: GO:0061525 name: hindgut development namespace: biological_process def: "The process whose specific outcome is the progression of the hindgut over time, from its formation to the mature structure. The hindgut is part of the alimentary canal that lies posterior to the midgut." [GOC:dph] is_a: GO:0048565 ! digestive tract development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0001046 ! results in development of hindgut relationship: RO:0002296 UBERON:0001046 ! results in development of hindgut creation_date: 2013-06-14T11:22:21Z [Term] id: GO:0061526 name: acetylcholine secretion namespace: biological_process def: "The regulated release of acetylcholine by a cell." [GOC:dph] is_a: GO:0015870 ! acetylcholine transport is_a: GO:0023061 ! signal release intersection_of: GO:0046903 ! secretion intersection_of: RO:0004009 CHEBI:15355 ! has primary input creation_date: 2013-06-21T15:40:39Z [Term] id: GO:0061527 name: dopamine secretion, neurotransmission namespace: biological_process def: "The regulated release of dopamine by a cell in which the dopamine acts as a neurotransmitter." [GOC:dph] is_a: GO:0099124 ! axonal dopamine secretion is_a: GO:0160043 ! catecholamine secretion, neurotransmission intersection_of: GO:0007269 ! neurotransmitter secretion intersection_of: RO:0004009 CHEBI:59905 ! has primary input relationship: BFO:0000050 GO:0001963 ! part of synaptic transmission, dopaminergic creation_date: 2013-06-21T15:43:15Z [Term] id: GO:0061533 name: norepinephrine secretion, neurotransmission namespace: biological_process def: "The regulated release of norepinephrine by a cell, in which the norepinephrine acts as a neurotransmitter." [GOC:dph] synonym: "noradrenaline secretion, neurotransmission" EXACT [GOC:dph] is_a: GO:0048243 ! norepinephrine secretion is_a: GO:0160043 ! catecholamine secretion, neurotransmission intersection_of: GO:0007269 ! neurotransmitter secretion intersection_of: RO:0004009 CHEBI:72587 ! has primary input creation_date: 2013-06-21T16:05:08Z [Term] id: GO:0061534 name: gamma-aminobutyric acid secretion, neurotransmission namespace: biological_process def: "The regulated release of gamma-aminobutyric acid by a cell, in which the gamma-aminobutyric acid acts as a neurotransmitter." [GOC:dph] is_a: GO:0007269 ! neurotransmitter secretion is_a: GO:0014051 ! gamma-aminobutyric acid secretion intersection_of: GO:0007269 ! neurotransmitter secretion intersection_of: RO:0004009 CHEBI:59888 ! has primary input relationship: BFO:0000050 GO:0051932 ! part of synaptic transmission, GABAergic creation_date: 2013-06-21T16:10:50Z [Term] id: GO:0061535 name: glutamate secretion, neurotransmission namespace: biological_process def: "The controlled release of glutamate by a cell, in which the glutamate acts as a neurotransmitter." [GOC:dph] is_a: GO:0007269 ! neurotransmitter secretion is_a: GO:0014047 ! glutamate secretion is_a: GO:0051938 ! L-glutamate import intersection_of: GO:0007269 ! neurotransmitter secretion intersection_of: RO:0004009 CHEBI:29985 ! has primary input relationship: BFO:0000050 GO:0035249 ! part of synaptic transmission, glutamatergic creation_date: 2013-06-21T16:14:47Z [Term] id: GO:0061536 name: glycine secretion namespace: biological_process def: "The controlled release of glycine by a cell." [GOC:dph] is_a: GO:0015816 ! glycine transport is_a: GO:0032940 ! secretion by cell intersection_of: GO:0046903 ! secretion intersection_of: RO:0004009 CHEBI:57305 ! has primary input creation_date: 2013-06-21T16:18:23Z [Term] id: GO:0061537 name: glycine secretion, neurotransmission namespace: biological_process def: "The controlled release of glycine by a cell, in which glycine acts as a neurotransmitter." [GOC:dph] is_a: GO:0007269 ! neurotransmitter secretion is_a: GO:0061536 ! glycine secretion intersection_of: GO:0007269 ! neurotransmitter secretion intersection_of: RO:0004009 CHEBI:57305 ! has primary input relationship: BFO:0000050 GO:0060012 ! part of synaptic transmission, glycinergic creation_date: 2013-06-21T16:19:02Z [Term] id: GO:0061538 name: histamine secretion, neurotransmission namespace: biological_process def: "The controlled release of histamine by a cell, in which the histamine acts as a neurotransmitter." [GOC:dph] is_a: GO:0001821 ! histamine secretion is_a: GO:0007269 ! neurotransmitter secretion is_a: GO:0015695 ! organic cation transport is_a: GO:0015801 ! aromatic amino acid transport is_a: GO:0015807 ! L-amino acid transport intersection_of: GO:0007269 ! neurotransmitter secretion intersection_of: RO:0004009 CHEBI:57595 ! has primary input relationship: RO:0004009 CHEBI:57595 ! has primary input creation_date: 2013-06-21T16:21:21Z [Term] id: GO:0061544 name: peptide secretion, neurotransmission namespace: biological_process def: "The controlled release of a peptide from a cell in which the peptide acts as a neurotransmitter." [GOC:dph] is_a: GO:0002790 ! peptide secretion is_a: GO:0007269 ! neurotransmitter secretion creation_date: 2013-06-25T09:10:10Z [Term] id: GO:0061548 name: ganglion development namespace: biological_process def: "The process whose specific outcome is the progression of a ganglion over time, from its formation to the mature structure." [GOC:dph] synonym: "ganglia development" RELATED [GOC:dph] synonym: "gangliogenesis" NARROW [GOC:BHF, GOC:rl] is_a: GO:0009888 ! tissue development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0000045 ! results in development of ganglion relationship: BFO:0000050 GO:0007399 ! part of nervous system development relationship: RO:0002296 UBERON:0000045 ! results in development of ganglion creation_date: 2013-07-10T08:36:12Z [Term] id: GO:0061549 name: sympathetic ganglion development namespace: biological_process def: "The process whose specific outcome is the progression of a sympathetic ganglion over time, from its formation to the mature structure." [GOC:BHF, GOC:rl] synonym: "sympathetic ganglia development" RELATED [GOC:dph] is_a: GO:0061548 ! ganglion development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0001806 ! results in development of sympathetic ganglion relationship: BFO:0000050 GO:0048485 ! part of sympathetic nervous system development relationship: RO:0002296 UBERON:0001806 ! results in development of sympathetic ganglion creation_date: 2013-07-10T08:38:01Z [Term] id: GO:0061550 name: cranial ganglion development namespace: biological_process def: "The process whose specific outcome is the progression of a cranial ganglion over time, from its formation to the mature structure." [GOC:dph] synonym: "cranial ganglia development" RELATED [GOC:dph] is_a: GO:0061548 ! ganglion development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0001714 ! results in development of cranial ganglion relationship: BFO:0000050 GO:0021545 ! part of cranial nerve development relationship: RO:0002296 UBERON:0001714 ! results in development of cranial ganglion creation_date: 2013-07-10T08:40:14Z [Term] id: GO:0061551 name: trigeminal ganglion development namespace: biological_process def: "The process whose specific outcome is the progression of a trigeminal ganglion over time, from its formation to the mature structure." [GOC:dph] synonym: "trigeminal ganglia development" RELATED [GOC:dph] is_a: GO:0061550 ! cranial ganglion development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0001675 ! results in development of trigeminal ganglion relationship: RO:0002296 UBERON:0001675 ! results in development of trigeminal ganglion creation_date: 2013-07-10T08:42:19Z [Term] id: GO:0061552 name: ganglion morphogenesis namespace: biological_process def: "The process in which the anatomical structures of ganglion are generated and organized." [GOC:dph] synonym: "ganglia morphogenesis" RELATED [GOC:dph] is_a: GO:0048729 ! tissue morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0000045 ! results in morphogenesis of ganglion relationship: BFO:0000050 GO:0061548 ! part of ganglion development relationship: RO:0002298 UBERON:0000045 ! results in morphogenesis of ganglion creation_date: 2013-07-10T08:44:57Z [Term] id: GO:0061553 name: ganglion maturation namespace: biological_process def: "A developmental process, independent of morphogenetic (shape) change, that is required for ganglion to attain its fully functional state." [GOC:dph] synonym: "ganglia maturation" RELATED [GOC:dph] is_a: GO:0071695 ! anatomical structure maturation intersection_of: GO:0071695 ! anatomical structure maturation intersection_of: RO:0002299 UBERON:0000045 ! results in maturation of ganglion relationship: BFO:0000050 GO:0061548 ! part of ganglion development relationship: RO:0002299 UBERON:0000045 ! results in maturation of ganglion creation_date: 2013-07-10T08:45:59Z [Term] id: GO:0061554 name: ganglion formation namespace: biological_process def: "The process that gives rise to ganglion. This process pertains to the initial formation of a structure from unspecified parts." [GOC:dph] synonym: "ganglia formation" RELATED [GOC:dph] is_a: BFO:0000003 is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0000045 ! results in formation of anatomical entity ganglion relationship: BFO:0000050 GO:0061552 ! part of ganglion morphogenesis relationship: RO:0002297 UBERON:0000045 ! results in formation of anatomical entity ganglion creation_date: 2013-07-10T08:51:50Z [Term] id: GO:0061556 name: trigeminal ganglion morphogenesis namespace: biological_process def: "The process in which the anatomical structure of a trigeminal ganglion is generated and organized." [GOC:dph] synonym: "trigeminal ganglia morphogenesis" RELATED [GOC:dph] is_a: GO:0061559 ! cranial ganglion morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0001675 ! results in morphogenesis of trigeminal ganglion relationship: BFO:0000050 GO:0021636 ! part of trigeminal nerve morphogenesis relationship: BFO:0000050 GO:0061551 ! part of trigeminal ganglion development relationship: RO:0002298 UBERON:0001675 ! results in morphogenesis of trigeminal ganglion creation_date: 2013-07-10T08:57:12Z [Term] id: GO:0061557 name: trigeminal ganglion maturation namespace: biological_process def: "A developmental process, independent of morphogenetic (shape) change, that is required for a trigeminal ganglion to attain its fully functional state." [GOC:dph] synonym: "trigeminal ganglia maturation" RELATED [GOC:dph] is_a: GO:0061558 ! cranial ganglion maturation intersection_of: GO:0071695 ! anatomical structure maturation intersection_of: RO:0002299 UBERON:0001675 ! results in maturation of trigeminal ganglion relationship: BFO:0000050 GO:0021635 ! part of trigeminal nerve maturation relationship: BFO:0000050 GO:0061551 ! part of trigeminal ganglion development relationship: RO:0002299 UBERON:0001675 ! results in maturation of trigeminal ganglion creation_date: 2013-07-10T08:58:24Z [Term] id: GO:0061558 name: cranial ganglion maturation namespace: biological_process def: "A developmental process, independent of morphogenetic (shape) change, that is required for a cranial ganglion to attain its fully functional state." [GOC:dph] synonym: "cranial ganglia maturation" RELATED [GOC:dph] is_a: GO:0061553 ! ganglion maturation intersection_of: GO:0071695 ! anatomical structure maturation intersection_of: RO:0002299 UBERON:0001714 ! results in maturation of cranial ganglion relationship: BFO:0000050 GO:0021605 ! part of cranial nerve maturation relationship: BFO:0000050 GO:0061550 ! part of cranial ganglion development relationship: RO:0002299 UBERON:0001714 ! results in maturation of cranial ganglion creation_date: 2013-07-10T08:59:52Z [Term] id: GO:0061559 name: cranial ganglion morphogenesis namespace: biological_process def: "The process in which the anatomical structure of a cranial ganglion is generated and organized." [GOC:dph] synonym: "cranial ganglia morphogenesis" RELATED [GOC:dph] is_a: GO:0061552 ! ganglion morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0001714 ! results in morphogenesis of cranial ganglion relationship: BFO:0000050 GO:0021602 ! part of cranial nerve morphogenesis relationship: BFO:0000050 GO:0061550 ! part of cranial ganglion development relationship: RO:0002298 UBERON:0001714 ! results in morphogenesis of cranial ganglion creation_date: 2013-07-10T09:02:15Z [Term] id: GO:0061560 name: cranial ganglion formation namespace: biological_process def: "The process that gives rise to a cranial ganglion. This process pertains to the initial formation of a structure from unspecified parts." [GOC:dph] synonym: "cranial ganglia formation" RELATED [GOC:dph] is_a: GO:0061554 ! ganglion formation intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0001714 ! results in formation of anatomical entity cranial ganglion relationship: BFO:0000050 GO:0061559 ! part of cranial ganglion morphogenesis relationship: RO:0002297 UBERON:0001714 ! results in formation of anatomical entity cranial ganglion creation_date: 2013-07-10T09:07:27Z [Term] id: GO:0061561 name: trigeminal ganglion formation namespace: biological_process def: "The process that gives rise to the trigeminal ganglion. This process pertains to the initial formation of a structure from unspecified parts." [GOC:dph] synonym: "trigeminal ganglia formation" RELATED [GOC:dph] is_a: GO:0061560 ! cranial ganglion formation intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0001675 ! results in formation of anatomical entity trigeminal ganglion relationship: BFO:0000050 GO:0061556 ! part of trigeminal ganglion morphogenesis relationship: RO:0002297 UBERON:0001675 ! results in formation of anatomical entity trigeminal ganglion creation_date: 2013-07-10T09:08:13Z [Term] id: GO:0061564 name: axon development namespace: biological_process def: "The progression of an axon over time. Covers axonogenesis (de novo generation of an axon) and axon regeneration (regrowth), as well as processes pertaining to the progression of the axon over time (fasciculation and defasciculation)." [GOC:dph, GOC:pg, GOC:pr] is_a: GO:0031175 ! neuron projection development creation_date: 2013-07-18T14:43:01Z [Term] id: GO:0061572 name: actin filament bundle organization namespace: biological_process def: "A process that results in the assembly, arrangement of constituent parts, or disassembly of an actin filament bundle." [GOC:dph] synonym: "actin filament cable organization" RELATED [GOC:dph] is_a: GO:0007015 ! actin filament organization intersection_of: GO:0016043 ! cellular component organization intersection_of: RO:0002592 GO:0032432 ! results in organization of actin filament bundle relationship: RO:0002592 GO:0032432 ! results in organization of actin filament bundle creation_date: 2013-08-02T11:24:11Z [Term] id: GO:0061580 name: colon epithelial cell migration namespace: biological_process def: "The orderly movement of a colonic epithelial cell from one site to another, often during the development of a multicellular organism." [GOC:dph] is_a: GO:0061582 ! intestinal epithelial cell migration intersection_of: GO:0016477 ! cell migration intersection_of: RO:0002565 CL:0011108 ! results in movement of colon epithelial cell relationship: RO:0002565 CL:0011108 ! results in movement of colon epithelial cell property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4890 creation_date: 2013-12-23T07:26:54Z [Term] id: GO:0061581 name: corneal epithelial cell migration namespace: biological_process def: "The orderly movement of a corneal epithelial cell from one site to another, often during the development of a multicellular organism." [GOC:dph] is_a: GO:0010631 ! epithelial cell migration intersection_of: GO:0016477 ! cell migration intersection_of: RO:0002565 CL:0000575 ! results in movement of corneal epithelial cell relationship: RO:0002565 CL:0000575 ! results in movement of corneal epithelial cell property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4890 creation_date: 2013-12-23T07:28:29Z [Term] id: GO:0061582 name: intestinal epithelial cell migration namespace: biological_process def: "The orderly movement of an intestinal epithelial cell from one site to another, often during the development of a multicellular organism." [GOC:dph] is_a: GO:0010631 ! epithelial cell migration intersection_of: GO:0016477 ! cell migration intersection_of: RO:0002565 CL:0002563 ! results in movement of intestinal epithelial cell relationship: RO:0002565 CL:0002563 ! results in movement of intestinal epithelial cell property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4890 creation_date: 2013-12-23T07:30:55Z [Term] id: GO:0061584 name: orexin secretion namespace: biological_process def: "The controlled release of orexin from a cell or a tissue." [GOC:dph] synonym: "hypocretin secretion" EXACT [] is_a: GO:0002790 ! peptide secretion property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/23504" xsd:anyURI creation_date: 2013-12-26T10:07:38Z [Term] id: GO:0061585 name: orexin secretion, neurotransmission namespace: biological_process def: "The controlled release of orexin from a cell in which orexin acts as a neurotransmitter." [GOC:dph] synonym: "hypocretin secretion, neurotransmission" EXACT [] is_a: GO:0061544 ! peptide secretion, neurotransmission is_a: GO:0061584 ! orexin secretion property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/23504" xsd:anyURI creation_date: 2013-12-26T10:09:37Z [Term] id: GO:0061626 name: pharyngeal arch artery morphogenesis namespace: biological_process def: "The process in which the anatomical structures of a pharyngeal arch artery is generated and organized. The pharyngeal arch arteries are a series of six paired embryological vascular structures, the development of which give rise to several major arteries, such as the stapedial artery, the middle meningeal artery, the internal carotid artery and the pulmonary artery." [GOC:BHF, GOC:dph, PMID:20122914] synonym: "aortic arch artery morphogenesis" BROAD [GOC:dph] is_a: GO:0048844 ! artery morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0004363 ! results in morphogenesis of pharyngeal arch artery relationship: BFO:0000050 GO:0060037 ! part of pharyngeal system development relationship: RO:0002298 UBERON:0004363 ! results in morphogenesis of pharyngeal arch artery creation_date: 2014-05-09T15:34:06Z [Term] id: GO:0061629 name: RNA polymerase II-specific DNA-binding transcription factor binding namespace: molecular_function def: "Binding to a sequence-specific DNA binding RNA polymerase II transcription factor, any of the factors that interact selectively and non-covalently with a specific DNA sequence in order to modulate transcription." [GOC:dph, GOC:vw] synonym: "RNA polymerase II activating transcription factor binding" RELATED [] synonym: "RNA polymerase II repressing transcription factor binding" RELATED [] synonym: "RNA polymerase II sequence-specific DNA binding transcription factor binding" EXACT [] synonym: "RNA polymerase II sequence-specific DNA-binding transcription factor binding" EXACT [] synonym: "RNA polymerase II transcription factor binding" RELATED [] is_a: GO:0140297 ! DNA-binding transcription factor binding property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/19354" xsd:anyURI creation_date: 2014-05-15T09:12:24Z [Term] id: GO:0061668 name: mitochondrial ribosome assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of the mitochondrial ribosome and of its subunits." [GOC:dph] is_a: GO:0042255 ! ribosome assembly intersection_of: GO:0022607 ! cellular component assembly intersection_of: RO:0002588 GO:0005761 ! results in assembly of mitochondrial ribosome relationship: RO:0002588 GO:0005761 ! results in assembly of mitochondrial ribosome creation_date: 2014-11-07T15:32:20Z [Term] id: GO:0061682 name: seminal vesicle morphogenesis namespace: biological_process def: "The process in which the anatomical structures of a seminal vesicle are generated and organized." [GOC:dph] is_a: GO:0022612 ! gland morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0000998 ! results in morphogenesis of seminal vesicle relationship: BFO:0000050 GO:0061107 ! part of seminal vesicle development relationship: RO:0002298 UBERON:0000998 ! results in morphogenesis of seminal vesicle creation_date: 2015-03-04T13:33:49Z [Term] id: GO:0061683 name: branching involved in seminal vesicle morphogenesis namespace: biological_process def: "The process in which the branching structure of the seminal vesicle is generated and organized. A branch is a division or offshoot from a main stem." [GOC:dph, PMID:16916376] synonym: "gonecyst branching morphogenesis" EXACT [GOC:dph] synonym: "seminal gland branching morphogenesis" EXACT [GOC:dph] synonym: "seminal vesicle branching" EXACT [GOC:dph] synonym: "seminal vesicle branching morphogenesis" EXACT [GOC:dph] is_a: GO:0061138 ! morphogenesis of a branching epithelium intersection_of: GO:0061138 ! morphogenesis of a branching epithelium intersection_of: BFO:0000050 GO:0061682 ! part of seminal vesicle morphogenesis relationship: BFO:0000050 GO:0061108 ! part of seminal vesicle epithelium development relationship: BFO:0000050 GO:0061682 ! part of seminal vesicle morphogenesis creation_date: 2015-03-04T13:39:47Z [Term] id: GO:0061687 name: detoxification of inorganic compound namespace: biological_process def: "Any process that reduces or removes the toxicity of inorganic compounds. These include transport of such compounds away from sensitive areas and to compartments or complexes whose purpose is sequestration of inorganic compounds." [GOC:vw] is_a: BFO:0000003 is_a: GO:0098754 ! detoxification intersection_of: GO:0098754 ! detoxification intersection_of: RO:0004009 CHEBI:24835 ! has primary input relationship: RO:0004009 CHEBI:24835 ! has primary input creation_date: 2015-03-09T09:16:23Z [Term] id: GO:0061695 name: transferase complex, transferring phosphorus-containing groups namespace: cellular_component def: "A transferase complex capable of catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:bhm, GOC:dph] is_a: GO:1990234 ! transferase complex intersection_of: GO:0032991 ! protein-containing complex intersection_of: RO:0002215 GO:0016772 ! capable of transferase activity, transferring phosphorus-containing groups relationship: RO:0002215 GO:0016772 ! capable of transferase activity, transferring phosphorus-containing groups creation_date: 2015-05-06T11:22:38Z [Term] id: GO:0061725 name: cytosolic lipolysis namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of lipid droplets and hydrolysis of stored triglycerides occurring through the orchestrated activation of cytosolic lipases." [GOC:autophagy] is_a: GO:0016042 ! lipid catabolic process intersection_of: GO:0009056 ! catabolic process intersection_of: BFO:0000066 GO:0005829 ! occurs in cytosol intersection_of: RO:0004009 CHEBI:18059 ! has primary input relationship: BFO:0000066 GO:0005829 ! occurs in cytosol property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/28908" xsd:anyURI creation_date: 2015-07-08T13:42:15Z [Term] id: GO:0061792 name: secretory granule maturation namespace: biological_process def: "Steps required to transform an immature secretory vesicle into a mature secretory vesicle. Typically proceeds through homotypic membrane fusion and membrane remodeling." [GOC:bf, GOC:dph, GOC:PARL, PMID:16618809] is_a: GO:0033363 ! secretory granule organization is_a: GO:0071695 ! anatomical structure maturation intersection_of: GO:0021700 ! developmental maturation intersection_of: RO:0002299 GO:0030141 ! results in maturation of secretory granule relationship: RO:0002299 GO:0030141 ! results in maturation of secretory granule property_value: RO:0002161 NCBITaxon:4890 creation_date: 2016-09-09T13:24:34Z [Term] id: GO:0061842 name: microtubule organizing center localization namespace: biological_process def: "Any process in which the microtubule organizing center is transported to, and/or maintained in, a specific location within the cell." [PMID:21281821] synonym: "microtubule organizing center polarity" NARROW [] synonym: "MTOC localization" EXACT [] synonym: "MTOC polarity" NARROW [] is_a: BFO:0000003 is_a: GO:0009987 ! cellular process is_a: GO:0051179 ! localization intersection_of: GO:0051179 ! localization intersection_of: RO:0004009 GO:0005815 ! has primary input microtubule organizing center relationship: RO:0004009 GO:0005815 ! has primary input microtubule organizing center [Term] id: GO:0061844 name: antimicrobial humoral immune response mediated by antimicrobial peptide namespace: biological_process def: "An immune response against microbes mediated by anti-microbial peptides in body fluid." [PMID:15761415, PMID:24287494] synonym: "antimicrobial peptide-mediated antimicrobial humoral response" EXACT [] synonym: "peptide-mediated antimicrobial humoral response" BROAD [] is_a: GO:0019730 ! antimicrobial humoral response property_value: RO:0002161 NCBITaxon:4895 [Term] id: GO:0061847 name: response to cholecystokinin namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cholecystokinin stimulus." [PMID:14622258] is_a: GO:0043434 ! response to peptide hormone intersection_of: GO:0050896 ! response to stimulus intersection_of: RO:0004009 PR:000005110 ! has primary input cholecystokinin relationship: RO:0004009 PR:000005110 ! has primary input cholecystokinin property_value: RO:0002161 NCBITaxon:4751 [Term] id: GO:0061848 name: cellular response to cholecystokinin namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cholecystokinin stimulus." [PMID:14622258] is_a: GO:0061847 ! response to cholecystokinin is_a: GO:0071375 ! cellular response to peptide hormone stimulus intersection_of: GO:0051716 ! cellular response to stimulus intersection_of: RO:0004009 PR:000005110 ! has primary input cholecystokinin property_value: RO:0002161 NCBITaxon:4751 [Term] id: GO:0061853 name: regulation of neuroblast migration namespace: biological_process def: "Any process that modulates the frequency, rate or extent of neuroblast migration." [PMID:23149556] is_a: GO:0030334 ! regulation of cell migration intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0097402 ! regulates neuroblast migration relationship: RO:0002211 GO:0097402 ! regulates neuroblast migration property_value: RO:0002161 NCBITaxon:451864 creation_date: 2017-03-08T18:17:07Z [Term] id: GO:0061854 name: positive regulation of neuroblast migration namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of neuroblast migration." [PMID:23149556] is_a: GO:0030335 ! positive regulation of cell migration is_a: GO:0061853 ! regulation of neuroblast migration intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0097402 ! positively regulates neuroblast migration relationship: RO:0002213 GO:0097402 ! positively regulates neuroblast migration property_value: RO:0002161 NCBITaxon:451864 creation_date: 2017-03-08T18:22:30Z [Term] id: GO:0061855 name: negative regulation of neuroblast migration namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of neuroblast migration." [PMID:23149556] is_a: GO:0030336 ! negative regulation of cell migration is_a: GO:0061853 ! regulation of neuroblast migration intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0097402 ! negatively regulates neuroblast migration relationship: RO:0002212 GO:0097402 ! negatively regulates neuroblast migration property_value: RO:0002161 NCBITaxon:451864 creation_date: 2017-03-08T18:26:21Z [Term] id: GO:0061856 name: Golgi calcium ion transmembrane transport namespace: biological_process def: "A process in which a calcium ion is transported from one side of a Golgi membrane to the other by means of some agent such as a transporter or pore." [PMID:21811607] is_a: GO:0032472 ! Golgi calcium ion transport is_a: GO:0070588 ! calcium ion transmembrane transport intersection_of: GO:0055085 ! transmembrane transport intersection_of: RO:0002344 GO:0005794 ! results in transport to from or in Golgi apparatus intersection_of: RO:0004009 CHEBI:29108 ! has primary input creation_date: 2017-03-14T16:08:23Z [Term] id: GO:0061868 name: hepatic stellate cell migration namespace: biological_process def: "The orderly movement of a hepatic stellate cell from one site to another." [PMID:24204762] is_a: GO:0010761 ! fibroblast migration intersection_of: GO:0016477 ! cell migration intersection_of: RO:0002565 CL:0000632 ! results in movement of hepatic stellate cell relationship: RO:0002565 CL:0000632 ! results in movement of hepatic stellate cell property_value: RO:0002161 NCBITaxon:4890 creation_date: 2017-05-01T13:01:40Z [Term] id: GO:0061869 name: regulation of hepatic stellate cell migration namespace: biological_process def: "Any process that modulates the frequency, rate or extent of hepatic stellate cell migration." [PMID:24204762] is_a: GO:0010762 ! regulation of fibroblast migration intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0061868 ! regulates hepatic stellate cell migration relationship: RO:0002211 GO:0061868 ! regulates hepatic stellate cell migration property_value: RO:0002161 NCBITaxon:451864 creation_date: 2017-05-01T13:04:20Z [Term] id: GO:0061870 name: positive regulation of hepatic stellate cell migration namespace: biological_process def: "Any process that increases the frequency, rate or extent of hepatic stellate cell migration." [PMID:24204762] is_a: GO:0010763 ! positive regulation of fibroblast migration is_a: GO:0061869 ! regulation of hepatic stellate cell migration intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0061868 ! positively regulates hepatic stellate cell migration relationship: RO:0002213 GO:0061868 ! positively regulates hepatic stellate cell migration property_value: RO:0002161 NCBITaxon:451864 creation_date: 2017-05-01T13:17:23Z [Term] id: GO:0061871 name: negative regulation of hepatic stellate cell migration namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of hepatic stellate cell migration." [PMID:24204762] is_a: GO:0010764 ! negative regulation of fibroblast migration is_a: GO:0061869 ! regulation of hepatic stellate cell migration intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0061868 ! negatively regulates hepatic stellate cell migration relationship: RO:0002212 GO:0061868 ! negatively regulates hepatic stellate cell migration property_value: RO:0002161 NCBITaxon:451864 creation_date: 2017-05-01T13:20:51Z [Term] id: GO:0061880 name: regulation of anterograde axonal transport of mitochondrion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the directed movement of mitochondria along microtubules in axons away from the cell body and towards the presynapse." [PMID:24302729] synonym: "regulation of anterograde axon transport of mitochondria" EXACT [] is_a: GO:1902513 ! regulation of organelle transport along microtubule intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0098957 ! regulates anterograde axonal transport of mitochondrion relationship: RO:0002211 GO:0098957 ! regulates anterograde axonal transport of mitochondrion creation_date: 2017-05-30T14:15:46Z [Term] id: GO:0061881 name: positive regulation of anterograde axonal transport of mitochondrion namespace: biological_process def: "Any process that activates or increasesthe frequency, rate or extent of the directed movement of mitochondria along microtubules in axons away from the cell body and towards the presynapse." [PMID:24302729] synonym: "positive regulation of anterograde axon transport of mitochondria" EXACT [] is_a: GO:0032388 ! positive regulation of intracellular transport is_a: GO:0061880 ! regulation of anterograde axonal transport of mitochondrion intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0098957 ! positively regulates anterograde axonal transport of mitochondrion relationship: RO:0002213 GO:0098957 ! positively regulates anterograde axonal transport of mitochondrion creation_date: 2017-05-30T14:21:08Z [Term] id: GO:0061882 name: negative regulation of anterograde axonal transport of mitochondrion namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of mitochondria along microtubules in axons away from the cell body and towards the presynapse." [PMID:24302729] synonym: "negative regulation of anterograde axon transport of mitochondria" EXACT [] is_a: GO:0032387 ! negative regulation of intracellular transport is_a: GO:0061880 ! regulation of anterograde axonal transport of mitochondrion intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0098957 ! negatively regulates anterograde axonal transport of mitochondrion relationship: RO:0002212 GO:0098957 ! negatively regulates anterograde axonal transport of mitochondrion creation_date: 2017-05-30T14:25:16Z [Term] id: GO:0061888 name: regulation of astrocyte activation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of astrocyte activation." [GOC:aruk, GOC:bc, PMID:20005821] is_a: GO:0048710 ! regulation of astrocyte differentiation is_a: GO:0050865 ! regulation of cell activation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0048143 ! regulates astrocyte activation relationship: RO:0002211 GO:0048143 ! regulates astrocyte activation creation_date: 2017-06-01T22:26:29Z [Term] id: GO:0061889 name: negative regulation of astrocyte activation namespace: biological_process def: "Any process that decreases the frequency, rate or extent of astrocyte activation." [GOC:aruk, GOC:bc, PMID:20005821] is_a: GO:0048712 ! negative regulation of astrocyte differentiation is_a: GO:0050866 ! negative regulation of cell activation is_a: GO:0061888 ! regulation of astrocyte activation is_a: GO:0150079 ! negative regulation of neuroinflammatory response intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0048143 ! negatively regulates astrocyte activation relationship: RO:0002212 GO:0048143 ! negatively regulates astrocyte activation creation_date: 2017-06-01T22:29:43Z [Term] id: GO:0061890 name: positive regulation of astrocyte activation namespace: biological_process def: "Any process that increases the frequency, rate or extent of astrocyte activation." [GOC:aruk, GOC:bc, PMID:20005821] is_a: GO:0048711 ! positive regulation of astrocyte differentiation is_a: GO:0050867 ! positive regulation of cell activation is_a: GO:0061888 ! regulation of astrocyte activation is_a: GO:0150078 ! positive regulation of neuroinflammatory response intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0048143 ! positively regulates astrocyte activation relationship: RO:0002213 GO:0048143 ! positively regulates astrocyte activation creation_date: 2017-06-01T22:31:50Z [Term] id: GO:0061900 name: glial cell activation namespace: biological_process def: "A change in morphology and behavior of a glial cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor." [GOC:aruk, GOC:bc, PMID:18723082] is_a: BFO:0000003 is_a: GO:0001775 ! cell activation intersection_of: GO:0001775 ! cell activation intersection_of: RO:0004009 CL:0000125 ! has primary input glial cell relationship: BFO:0000050 GO:0150076 ! part of neuroinflammatory response relationship: RO:0004009 CL:0000125 ! has primary input glial cell creation_date: 2017-06-13T13:06:23Z [Term] id: GO:0061938 name: protein localization to somatodendritic compartment namespace: biological_process def: "A process in which a protein is transported to or maintained in a location within the somatodendritic compartment." [PMID:18341993] synonym: "somatodendritic protein localization" EXACT [] is_a: GO:0008104 ! intracellular protein localization intersection_of: GO:0008104 ! intracellular protein localization intersection_of: RO:0002339 GO:0036477 ! has target end location somatodendritic compartment relationship: RO:0002339 GO:0036477 ! has target end location somatodendritic compartment creation_date: 2017-09-08T13:22:26Z [Term] id: GO:0061951 name: establishment of protein localization to plasma membrane namespace: biological_process def: "The directed movement of a protein to a specific location in a plasma membrane." [GOC:dph, GOC:vw] is_a: GO:0090150 ! establishment of protein localization to membrane intersection_of: GO:0045184 ! establishment of protein localization intersection_of: RO:0002338 GO:0005622 ! has target start location intracellular anatomical structure intersection_of: RO:0002339 GO:0005886 ! has target end location plasma membrane relationship: RO:0002338 GO:0005622 ! has target start location intracellular anatomical structure relationship: RO:0002339 GO:0005886 ! has target end location plasma membrane creation_date: 2017-10-26T12:55:15Z [Term] id: GO:0061971 name: replacement bone morphogenesis namespace: biological_process def: "The process in which bones are generated and organized as a result of the conversion of another structural tissue into bone." [PMID:29852585] is_a: GO:0060349 ! bone morphogenesis intersection_of: GO:0060349 ! bone morphogenesis intersection_of: RO:0002298 UBERON:0012075 ! results in morphogenesis of replacement bone relationship: RO:0002298 UBERON:0012075 ! results in morphogenesis of replacement bone creation_date: 2018-02-12T18:10:59Z [Term] id: GO:0061972 name: dermal bone morphogenesis namespace: biological_process def: "The process in which bone which forms superficially in the organism are generated and organized." [PMID:12588850, PMID:15003632] is_a: GO:0061973 ! membrane bone morphogenesis intersection_of: GO:0060349 ! bone morphogenesis intersection_of: RO:0002298 UBERON:0008907 ! results in morphogenesis of dermal bone relationship: RO:0002298 UBERON:0008907 ! results in morphogenesis of dermal bone creation_date: 2018-02-12T18:16:21Z [Term] id: GO:0061973 name: membrane bone morphogenesis namespace: biological_process def: "The process in which bone which forms deep in the organism are generated and organized." [PMID:14579374] is_a: GO:0060349 ! bone morphogenesis intersection_of: GO:0060349 ! bone morphogenesis intersection_of: RO:0002298 UBERON:0007842 ! results in morphogenesis of membrane bone relationship: RO:0002298 UBERON:0007842 ! results in morphogenesis of membrane bone creation_date: 2018-02-12T18:21:09Z [Term] id: GO:0061983 name: meiosis II cell cycle process namespace: biological_process def: "A process that coontributes to the second meiotic division. The second meiotic division separates chromatids resulting in a haploid number of chromosomes." [PMID:29385397] synonym: "second meiotic division" EXACT [PMID:29385397] is_a: GO:1903046 ! meiotic cell cycle process creation_date: 2018-02-14T22:37:44Z [Term] id: GO:0062012 name: regulation of small molecule metabolic process namespace: biological_process def: "Any process that modulates the rate, frequency or extent of a small molecule metabolic process." [GOC:vw] synonym: "regulation of small molecule metabolism" EXACT [] xref: Reactome:R-HSA-9861718 "Regulation of pyruvate metabolism" is_a: GO:0019222 ! regulation of metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0044281 ! regulates small molecule metabolic process relationship: RO:0002211 GO:0044281 ! regulates small molecule metabolic process creation_date: 2018-03-19T14:11:54Z [Term] id: GO:0062013 name: positive regulation of small molecule metabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of a small molecule metabolic process." [GOC:vw] synonym: "positive regulation of small molecule metabolism" EXACT [] is_a: GO:0009893 ! positive regulation of metabolic process is_a: GO:0062012 ! regulation of small molecule metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0044281 ! positively regulates small molecule metabolic process relationship: RO:0002213 GO:0044281 ! positively regulates small molecule metabolic process creation_date: 2018-03-19T14:25:10Z [Term] id: GO:0062014 name: negative regulation of small molecule metabolic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of a small molecule metabolic process." [GOC:vw] synonym: "negative regulation of small molecule metabolism" EXACT [] is_a: GO:0009892 ! negative regulation of metabolic process is_a: GO:0062012 ! regulation of small molecule metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0044281 ! negatively regulates small molecule metabolic process relationship: RO:0002212 GO:0044281 ! negatively regulates small molecule metabolic process creation_date: 2018-03-19T14:27:23Z [Term] id: GO:0062033 name: positive regulation of mitotic sister chromatid segregation namespace: biological_process def: "Any process that starts or increases the frequency, rate or extent of sister chromatid segregation during mitosis." [PMID:12773390] is_a: GO:0033047 ! regulation of mitotic sister chromatid segregation is_a: GO:0051984 ! positive regulation of chromosome segregation is_a: GO:2001252 ! positive regulation of chromosome organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0000070 ! positively regulates mitotic sister chromatid segregation relationship: RO:0002213 GO:0000070 ! positively regulates mitotic sister chromatid segregation creation_date: 2018-04-23T14:32:23Z [Term] id: GO:0062056 name: compound eye pigment cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires the specialized features of a compound eye pigment cell, a cell of the retina containing screening pigments that functions to screen photoreceptors from light leaking from adjacent ommatidia." [GOC:ha, PMID:8929534] is_a: GO:0050931 ! pigment cell differentiation intersection_of: GO:0048869 ! cellular developmental process intersection_of: RO:0002315 CL:0001658 ! results in acquisition of features of visual pigment cell (sensu Nematoda and Protostomia) relationship: BFO:0000050 GO:0001745 ! part of compound eye morphogenesis relationship: RO:0002315 CL:0001658 ! results in acquisition of features of visual pigment cell (sensu Nematoda and Protostomia) creation_date: 2018-08-01T12:59:42Z [Term] id: GO:0062094 name: stomach development namespace: biological_process def: "The process whose specific outcome is the progression of the stomach over time, from its formation to the mature structure. The stomach is an expanded region of the vertebrate alimentary tract that serves as a food storage compartment and digestive organ." [PMID:11967278] is_a: GO:0048856 ! anatomical structure development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0000945 ! results in development of stomach relationship: BFO:0000050 GO:0048565 ! part of digestive tract development relationship: RO:0002296 UBERON:0000945 ! results in development of stomach creation_date: 2018-11-20T18:15:45Z [Term] id: GO:0062125 name: regulation of mitochondrial gene expression namespace: biological_process def: "Any process that modulates the frequency, rate or extent of mitochondrial gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA)." [PMID:28285835] is_a: GO:0010468 ! regulation of gene expression intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0140053 ! regulates mitochondrial gene expression relationship: RO:0002211 GO:0140053 ! regulates mitochondrial gene expression creation_date: 2019-05-30T16:45:04Z [Term] id: GO:0062137 name: cargo receptor complex namespace: cellular_component def: "Any protein complex that is part of a membrane and which functions as a cargo receptor." [PMID:27903609] is_a: GO:0098796 ! membrane protein complex intersection_of: GO:0032991 ! protein-containing complex intersection_of: BFO:0000050 GO:0016020 ! part of membrane intersection_of: RO:0002215 GO:0038024 ! capable of cargo receptor activity relationship: RO:0002215 GO:0038024 ! capable of cargo receptor activity creation_date: 2019-07-08T18:09:01Z [Term] id: GO:0062149 name: detection of stimulus involved in sensory perception of pain namespace: biological_process def: "The series of events involved in the perception of pain in which a stimulus is received and converted into a molecular signal." [PMID:19837031] is_a: GO:0050906 ! detection of stimulus involved in sensory perception intersection_of: GO:0051606 ! detection of stimulus intersection_of: BFO:0000050 GO:0019233 ! part of sensory perception of pain relationship: BFO:0000050 GO:0019233 ! part of sensory perception of pain creation_date: 2019-09-13T13:48:47Z [Term] id: GO:0062171 name: lutein biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of lutein." [PMID:24397433] synonym: "lutein anabolism" EXACT [] synonym: "lutein biosynthesis" EXACT [] synonym: "lutein formation" EXACT [] is_a: GO:0016123 ! xanthophyll biosynthetic process intersection_of: GO:0009058 ! biosynthetic process intersection_of: RO:0004008 CHEBI:28838 ! has primary output relationship: RO:0004008 CHEBI:28838 ! has primary output property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 creation_date: 2019-11-18T16:01:00Z [Term] id: GO:0062172 name: lutein catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of lutein." [PMID:24397433] synonym: "lutein breakdown" EXACT [] synonym: "lutein catabolism" EXACT [] synonym: "lutein degradation" EXACT [] is_a: GO:0016124 ! xanthophyll catabolic process intersection_of: GO:0009056 ! catabolic process intersection_of: RO:0004009 CHEBI:28838 ! has primary input relationship: RO:0004009 CHEBI:28838 ! has primary input property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 creation_date: 2019-11-18T16:06:07Z [Term] id: GO:0062177 name: radial spoke assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form the radial spoke, a protein complex that links the outer microtubule doublet of the ciliary or flagellum axoneme with the sheath that surrounds the central pair of microtubules." [PMID:21613541, PMID:21692193, PMID:24124175, PMID:27940518, PMID:8408197] is_a: GO:0065003 ! protein-containing complex assembly intersection_of: GO:0009987 ! cellular process intersection_of: RO:0002588 GO:0001534 ! results in assembly of radial spoke relationship: BFO:0000050 GO:0035082 ! part of axoneme assembly relationship: RO:0002588 GO:0001534 ! results in assembly of radial spoke property_value: RO:0002161 NCBITaxon:3176 property_value: RO:0002161 NCBITaxon:3378 property_value: RO:0002161 NCBITaxon:3398 property_value: RO:0002161 NCBITaxon:4890 property_value: RO:0002161 NCBITaxon:5782 creation_date: 2019-11-20T17:50:08Z [Term] id: GO:0062197 name: cellular response to chemical stress namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chemical stimulus indicating the organism is under stress." [PMID:26653712] xref: Reactome:R-HSA-9711123 "Cellular response to chemical stress" is_a: GO:0033554 ! cellular response to stress is_a: GO:0070887 ! cellular response to chemical stimulus creation_date: 2019-12-10T14:42:03Z [Term] id: GO:0062236 name: ionocyte differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized structural and/or functional features of an ionocyte. Ionocytes are specialized epithelial cells that contribute to osmotic homeostasis." [PMID:17555741] is_a: GO:0030855 ! epithelial cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0005006 ! results in acquisition of features of ionocyte relationship: RO:0002315 CL:0005006 ! results in acquisition of features of ionocyte creation_date: 2020-04-20T12:30:35Z [Term] id: GO:0062237 name: protein localization to postsynapse namespace: biological_process def: "Any process in which a protein is transported to, and/or maintained at the postsynapse, the part of a synapse that is part of the post-synaptic cell." [PMID:31189538] is_a: GO:0035418 ! protein localization to synapse intersection_of: GO:0008104 ! intracellular protein localization intersection_of: RO:0002339 GO:0098794 ! has target end location postsynapse relationship: RO:0002339 GO:0098794 ! has target end location postsynapse creation_date: 2020-04-20T13:58:43Z [Term] id: GO:0062247 name: chloroplast vesicle namespace: cellular_component def: "A intracellular vesicle that is part of a chloroplast." [PMID:32245810] is_a: GO:0031410 ! cytoplasmic vesicle intersection_of: GO:0097708 ! intracellular vesicle intersection_of: BFO:0000050 GO:0009507 ! part of chloroplast relationship: BFO:0000050 GO:0009507 ! part of chloroplast property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:28009 property_value: RO:0002161 NCBITaxon:33208 property_value: RO:0002161 NCBITaxon:4751 property_value: RO:0002161 NCBITaxon:554915 creation_date: 2020-05-01T12:10:16Z [Term] id: GO:0065002 name: intracellular protein transmembrane transport namespace: biological_process def: "The directed movement of proteins in a cell, from one side of a membrane to another by means of some agent such as a transporter or pore." [GOC:isa_complete] comment: Note that this term is not intended for use in annotating lateral movement within membranes. synonym: "intracellular membrane translocation of a protein" EXACT [] synonym: "intracellular protein membrane transport" EXACT [] synonym: "intracellular protein transport across a membrane" EXACT [] is_a: GO:0006886 ! intracellular protein transport is_a: GO:0071806 ! protein transmembrane transport intersection_of: GO:0055085 ! transmembrane transport intersection_of: BFO:0000066 GO:0005622 ! occurs in intracellular anatomical structure intersection_of: RO:0004009 PR:000000001 ! has primary input protein [Term] id: GO:0065003 name: protein-containing complex assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of macromolecules to form a protein-containing complex." [GOC:jl] subset: goslim_chembl subset: goslim_drosophila subset: goslim_generic subset: goslim_metagenomics subset: goslim_pir subset: goslim_pombe subset: goslim_prokaryote synonym: "cellular macromolecule complex assembly" RELATED [] synonym: "cellular protein complex assembly" EXACT [] synonym: "cellular protein-containing complex assembly" RELATED [] synonym: "chaperone activity" RELATED [] synonym: "macromolecular complex assembly" RELATED [] synonym: "macromolecule complex assembly" RELATED [] synonym: "protein complex assembly" RELATED [] synonym: "protein complex formation" RELATED [] is_a: GO:0022607 ! cellular component assembly is_a: GO:0043933 ! protein-containing complex organization intersection_of: GO:0022607 ! cellular component assembly intersection_of: RO:0002588 GO:0032991 ! results in assembly of protein-containing complex relationship: RO:0002588 GO:0032991 ! results in assembly of protein-containing complex property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/22580" xsd:anyURI [Term] id: GO:0065005 name: protein-lipid complex assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of proteins and lipids to form a protein-lipid complex." [GOC:jl] is_a: GO:0065003 ! protein-containing complex assembly is_a: GO:0071825 ! protein-lipid complex organization intersection_of: GO:0022607 ! cellular component assembly intersection_of: RO:0002588 GO:0032994 ! results in assembly of protein-lipid complex relationship: RO:0002588 GO:0032994 ! results in assembly of protein-lipid complex [Term] id: GO:0065007 name: biological regulation namespace: biological_process def: "Any process that modulates a measurable attribute of any biological process, quality or function." [GOC:dph, GOC:isa_complete, GOC:mah, GOC:pr, GOC:vw] subset: gocheck_do_not_annotate subset: goslim_pir synonym: "regulation" BROAD [] is_a: GO:0008150 ! biological_process [Term] id: GO:0065008 name: regulation of biological quality namespace: biological_process def: "Any process that modulates a qualitative or quantitative trait of a biological quality. A biological quality is a measurable attribute of an organism or part of an organism, such as size, mass, shape, color, etc." [GOC:dph, GOC:isa_complete, GOC:mah, GOC:pr, GOC:vw] subset: gocheck_do_not_annotate subset: goslim_pir synonym: "regulation of biological attribute" EXACT [] synonym: "regulation of biological characteristic" EXACT [] is_a: GO:0065007 ! biological regulation property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/30599" xsd:anyURI [Term] id: GO:0065009 name: regulation of molecular function namespace: biological_process def: "Any process that modulates the frequency, rate or extent of a molecular function, an elemental biological activity occurring at the molecular level, such as catalysis or binding." [GOC:isa_complete] subset: gocheck_obsoletion_candidate subset: goslim_pir subset: goslim_plant synonym: "regulation of a molecular function" EXACT [] is_a: BFO:0000003 is_a: GO:0065007 ! biological regulation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0003674 ! regulates molecular_function relationship: RO:0002211 GO:0003674 ! regulates molecular_function [Term] id: GO:0065010 name: extracellular membrane-bounded organelle namespace: cellular_component def: "Organized structure of distinctive morphology and function, bounded by a lipid bilayer membrane and occurring outside the cell." [GOC:isa_complete] synonym: "extracellular membrane-enclosed organelle" EXACT [] is_a: GO:0043227 ! membrane-bounded organelle is_a: GO:0043230 ! extracellular organelle intersection_of: GO:0043227 ! membrane-bounded organelle intersection_of: BFO:0000050 GO:0005576 ! part of extracellular region [Term] id: GO:0070013 name: intracellular organelle lumen namespace: cellular_component def: "An organelle lumen that is part of an intracellular organelle." [GOC:mah] is_a: GO:0043233 ! organelle lumen intersection_of: GO:0031974 ! membrane-enclosed lumen intersection_of: BFO:0000050 GO:0043229 ! part of intracellular organelle relationship: BFO:0000050 GO:0043229 ! part of intracellular organelle property_value: skos:prefLabel "intracellular organelle lumen" xsd:string [Term] id: GO:0070050 name: neuron cellular homeostasis namespace: biological_process def: "The cellular homeostatic process that preserves a neuron in a stable, differentiated functional and structural state." [GOC:BHF, GOC:mah] synonym: "neuron maintenance" EXACT [] is_a: GO:0019725 ! cellular homeostasis intersection_of: GO:0019725 ! cellular homeostasis intersection_of: BFO:0000066 CL:0000540 ! occurs in neuron relationship: BFO:0000066 CL:0000540 ! occurs in neuron property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/24218" xsd:anyURI [Term] id: GO:0070051 name: fibrinogen binding namespace: molecular_function def: "Binding to fibrinogen, a highly soluble hexameric glycoprotein complex that is found in blood plasma and is converted to fibrin by thrombin in the coagulation cascade." [GOC:BHF, GOC:mah, GOC:vk] is_a: GO:0044877 ! protein-containing complex binding intersection_of: GO:0005488 ! binding intersection_of: RO:0004009 GO:0005577 ! has primary input fibrinogen complex relationship: RO:0004009 GO:0005577 ! has primary input fibrinogen complex [Term] id: GO:0070062 name: extracellular exosome namespace: cellular_component def: "A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm." [GOC:BHF, GOC:mah, GOC:vesicles, PMID:15908444, PMID:17641064, PMID:19442504, PMID:19498381, PMID:22418571, PMID:24009894] synonym: "exosome" EXACT [GOC:pr] synonym: "extracellular vesicular exosome" EXACT [GOC:vesicles] is_a: GO:1903561 ! extracellular vesicle relationship: BFO:0000050 GO:0005615 ! part of extracellular space property_value: RO:0002161 NCBITaxon:4890 [Term] id: GO:0070091 name: glucagon secretion namespace: biological_process def: "The regulated release of glucagon from secretory granules in the A (alpha) cells of the pancreas (islets of Langerhans)." [GOC:BHF, GOC:rl] is_a: GO:0030072 ! peptide hormone secretion intersection_of: GO:0046903 ! secretion intersection_of: RO:0004009 CHEBI:5391 ! has primary input relationship: RO:0004009 CHEBI:5391 ! has primary input [Term] id: GO:0070092 name: regulation of glucagon secretion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the regulated release of glucagon." [GOC:BHF, GOC:mah] is_a: GO:0090276 ! regulation of peptide hormone secretion intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0070091 ! regulates glucagon secretion relationship: RO:0002211 GO:0070091 ! regulates glucagon secretion [Term] id: GO:0070093 name: negative regulation of glucagon secretion namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of glucagon." [GOC:BHF, GOC:mah] synonym: "down regulation of glucagon secretion" EXACT [] synonym: "down-regulation of glucagon secretion" EXACT [] synonym: "downregulation of glucagon secretion" EXACT [] synonym: "inhibition of glucagon secretion" NARROW [] is_a: GO:0070092 ! regulation of glucagon secretion is_a: GO:0090278 ! negative regulation of peptide hormone secretion intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0070091 ! negatively regulates glucagon secretion relationship: RO:0002212 GO:0070091 ! negatively regulates glucagon secretion [Term] id: GO:0070094 name: positive regulation of glucagon secretion namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the regulated release of glucagon." [GOC:BHF, GOC:mah] synonym: "activation of glucagon secretion" NARROW [] synonym: "stimulation of glucagon secretion" NARROW [] synonym: "up regulation of glucagon secretion" EXACT [] synonym: "up-regulation of glucagon secretion" EXACT [] synonym: "upregulation of glucagon secretion" EXACT [] is_a: GO:0070092 ! regulation of glucagon secretion is_a: GO:0090277 ! positive regulation of peptide hormone secretion intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0070091 ! positively regulates glucagon secretion relationship: RO:0002213 GO:0070091 ! positively regulates glucagon secretion [Term] id: GO:0070124 name: mitochondrial translational initiation namespace: biological_process def: "The process preceding formation of the peptide bond between the first two amino acids of a protein in a mitochondrion. This includes the formation of a complex of the ribosome, mRNA, and an initiation complex that contains the first aminoacyl-tRNA." [GOC:mah] synonym: "mitochondrial translation initiation" EXACT [GOC:mah] xref: Reactome:R-HSA-5368286 "Mitochondrial translation initiation" is_a: GO:0006413 ! translational initiation intersection_of: GO:0006413 ! translational initiation intersection_of: BFO:0000066 GO:0005739 ! occurs in mitochondrion relationship: BFO:0000050 GO:0032543 ! part of mitochondrial translation [Term] id: GO:0070125 name: mitochondrial translational elongation namespace: biological_process def: "The successive addition of amino acid residues to a nascent polypeptide chain during protein biosynthesis in a mitochondrion." [GOC:mah] synonym: "mitochondrial translation elongation" EXACT [GOC:mah] xref: Reactome:R-HSA-5389840 "Mitochondrial translation elongation" is_a: GO:0006414 ! translational elongation intersection_of: GO:0006414 ! translational elongation intersection_of: BFO:0000066 GO:0005739 ! occurs in mitochondrion relationship: BFO:0000050 GO:0032543 ! part of mitochondrial translation [Term] id: GO:0070126 name: mitochondrial translational termination namespace: biological_process def: "The process resulting in the release of a polypeptide chain from the ribosome in a mitochondrion, usually in response to a termination codon (note that mitochondria use variants of the universal genetic code that differ between different taxa)." [GOC:mah, http://mitogenome.org/index.php/Genetic_Code_of_mitochondria] synonym: "mitochondrial translation termination" EXACT [GOC:mah] xref: Reactome:R-HSA-5419276 "Mitochondrial translation termination" is_a: GO:0006415 ! translational termination intersection_of: GO:0006415 ! translational termination intersection_of: BFO:0000066 GO:0005739 ! occurs in mitochondrion relationship: BFO:0000050 GO:0032543 ! part of mitochondrial translation [Term] id: GO:0070129 name: regulation of mitochondrial translation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA in a mitochondrion." [GOC:mah] synonym: "regulation of mitochondrial protein anabolism" EXACT [GOC:mah] synonym: "regulation of mitochondrial protein biosynthesis" EXACT [GOC:mah] synonym: "regulation of mitochondrial protein formation" EXACT [GOC:mah] synonym: "regulation of mitochondrial protein synthesis" EXACT [GOC:mah] is_a: GO:0006417 ! regulation of translation is_a: GO:0062125 ! regulation of mitochondrial gene expression intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0032543 ! regulates mitochondrial translation relationship: RO:0002211 GO:0032543 ! regulates mitochondrial translation [Term] id: GO:0070130 name: negative regulation of mitochondrial translation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA in a mitochondrion." [GOC:mah] synonym: "negative regulation of mitochondrial protein anabolism" EXACT [GOC:mah] synonym: "negative regulation of mitochondrial protein biosynthesis" EXACT [GOC:mah] synonym: "negative regulation of mitochondrial protein formation" EXACT [GOC:mah] synonym: "negative regulation of mitochondrial protein synthesis" EXACT [GOC:mah] is_a: GO:0017148 ! negative regulation of translation is_a: GO:0070129 ! regulation of mitochondrial translation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0032543 ! negatively regulates mitochondrial translation relationship: RO:0002212 GO:0032543 ! negatively regulates mitochondrial translation [Term] id: GO:0070131 name: positive regulation of mitochondrial translation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA in a mitochondrion." [GOC:mah] synonym: "positive regulation of mitochondrial protein anabolism" EXACT [GOC:mah] synonym: "positive regulation of mitochondrial protein biosynthesis" EXACT [GOC:mah] synonym: "positive regulation of mitochondrial protein formation" EXACT [GOC:mah] synonym: "positive regulation of mitochondrial protein synthesis" EXACT [GOC:mah] is_a: GO:0045727 ! positive regulation of translation is_a: GO:0070129 ! regulation of mitochondrial translation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0032543 ! positively regulates mitochondrial translation relationship: RO:0002213 GO:0032543 ! positively regulates mitochondrial translation [Term] id: GO:0070132 name: regulation of mitochondrial translational initiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the process preceding formation of the peptide bond between the first two amino acids of a protein in a mitochondrion." [GOC:mah] synonym: "regulation of mitochondrial translation initiation" EXACT [GOC:mah] is_a: GO:0006446 ! regulation of translational initiation is_a: GO:0070129 ! regulation of mitochondrial translation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0070124 ! regulates mitochondrial translational initiation relationship: RO:0002211 GO:0070124 ! regulates mitochondrial translational initiation [Term] id: GO:0070133 name: negative regulation of mitochondrial translational initiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the process preceding formation of the peptide bond between the first two amino acids of a protein in a mitochondrion." [GOC:mah] synonym: "negative regulation of mitochondrial translation initiation" EXACT [GOC:mah] is_a: GO:0045947 ! negative regulation of translational initiation is_a: GO:0070132 ! regulation of mitochondrial translational initiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0070124 ! negatively regulates mitochondrial translational initiation relationship: RO:0002212 GO:0070124 ! negatively regulates mitochondrial translational initiation [Term] id: GO:0070134 name: positive regulation of mitochondrial translational initiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the process preceding formation of the peptide bond between the first two amino acids of a protein in a mitochondrion." [GOC:mah] synonym: "positive regulation of mitochondrial translation initiation" EXACT [GOC:mah] is_a: GO:0045948 ! positive regulation of translational initiation is_a: GO:0070131 ! positive regulation of mitochondrial translation is_a: GO:0070132 ! regulation of mitochondrial translational initiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0070124 ! positively regulates mitochondrial translational initiation relationship: RO:0002213 GO:0070124 ! positively regulates mitochondrial translational initiation [Term] id: GO:0070160 name: tight junction namespace: cellular_component def: "A cell-cell junction that seals cells together in an epithelium in a way that prevents even small molecules from leaking from one side of the sheet to the other." [ISBN:0815332181] synonym: "occluding cell junction" EXACT [GOC:mah] synonym: "occluding junction" EXACT [GOC:mah] xref: Wikipedia:Tight_junction is_a: GO:0005911 ! cell-cell junction property_value: RO:0002161 NCBITaxon:4751 [Term] id: GO:0070161 name: anchoring junction namespace: cellular_component def: "A cell junction that mechanically attaches a cell (and its cytoskeleton) to neighboring cells or to the extracellular matrix." [ISBN:0815332181] synonym: "anchoring cell junction" EXACT [GOC:mah] is_a: GO:0030054 ! cell junction property_value: RO:0002161 NCBITaxon:4751 property_value: skos:prefLabel "anchoring junction" xsd:string [Term] id: GO:0070167 name: regulation of biomineral tissue development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of biomineral tissue development, the formation of hard tissues that consist mainly of inorganic compounds." [GOC:mah] is_a: GO:2000026 ! regulation of multicellular organismal development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0031214 ! regulates biomineral tissue development relationship: RO:0002211 GO:0031214 ! regulates biomineral tissue development property_value: RO:0002161 NCBITaxon:147554 property_value: RO:0002161 NCBITaxon:33630 property_value: RO:0002161 NCBITaxon:33682 property_value: RO:0002161 NCBITaxon:38254 property_value: RO:0002161 NCBITaxon:4891 [Term] id: GO:0070168 name: negative regulation of biomineral tissue development namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of biomineral tissue development, the formation of hard tissues that consist mainly of inorganic compounds." [GOC:mah] is_a: GO:0051093 ! negative regulation of developmental process is_a: GO:0070167 ! regulation of biomineral tissue development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0031214 ! negatively regulates biomineral tissue development relationship: RO:0002212 GO:0031214 ! negatively regulates biomineral tissue development property_value: RO:0002161 NCBITaxon:147554 property_value: RO:0002161 NCBITaxon:33630 property_value: RO:0002161 NCBITaxon:33682 property_value: RO:0002161 NCBITaxon:38254 property_value: RO:0002161 NCBITaxon:4891 [Term] id: GO:0070169 name: positive regulation of biomineral tissue development namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of biomineral tissue development, the formation of hard tissues that consist mainly of inorganic compounds." [GOC:mah] is_a: GO:0051094 ! positive regulation of developmental process is_a: GO:0070167 ! regulation of biomineral tissue development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0031214 ! positively regulates biomineral tissue development relationship: RO:0002213 GO:0031214 ! positively regulates biomineral tissue development property_value: RO:0002161 NCBITaxon:147554 property_value: RO:0002161 NCBITaxon:33630 property_value: RO:0002161 NCBITaxon:33682 property_value: RO:0002161 NCBITaxon:38254 property_value: RO:0002161 NCBITaxon:4891 [Term] id: GO:0070170 name: regulation of tooth mineralization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of tooth mineralization, the deposition of calcium salts in tooth structures." [GOC:BHF, GOC:mah] is_a: GO:0070167 ! regulation of biomineral tissue development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0034505 ! regulates tooth mineralization relationship: RO:0002211 GO:0034505 ! regulates tooth mineralization property_value: RO:0002161 NCBITaxon:8782 [Term] id: GO:0070171 name: negative regulation of tooth mineralization namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of tooth mineralization, the deposition of calcium salts in tooth structures." [GOC:BHF, GOC:mah] is_a: GO:0070168 ! negative regulation of biomineral tissue development is_a: GO:0070170 ! regulation of tooth mineralization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0034505 ! negatively regulates tooth mineralization relationship: RO:0002212 GO:0034505 ! negatively regulates tooth mineralization property_value: RO:0002161 NCBITaxon:8782 [Term] id: GO:0070172 name: positive regulation of tooth mineralization namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of tooth mineralization, the deposition of calcium salts in tooth structures." [GOC:BHF, GOC:mah] is_a: GO:0070169 ! positive regulation of biomineral tissue development is_a: GO:0070170 ! regulation of tooth mineralization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0034505 ! positively regulates tooth mineralization relationship: RO:0002213 GO:0034505 ! positively regulates tooth mineralization property_value: RO:0002161 NCBITaxon:8782 [Term] id: GO:0070192 name: chromosome organization involved in meiotic cell cycle namespace: biological_process def: "A process of chromosome organization that is involved in a meiotic cell cycle." [GOC:mah] synonym: "chromosome organisation involved in meiosis" EXACT [GOC:mah] synonym: "meiotic chromosome organization" EXACT [GOC:mah] is_a: GO:0051276 ! chromosome organization is_a: GO:1903046 ! meiotic cell cycle process intersection_of: GO:0051276 ! chromosome organization intersection_of: BFO:0000050 GO:0051321 ! part of meiotic cell cycle [Term] id: GO:0070199 name: establishment of protein localization to chromosome namespace: biological_process def: "The directed movement of a protein to a specific location on a chromosome." [GOC:BHF, GOC:mah] synonym: "establishment of protein localisation to chromosome" EXACT [GOC:mah] is_a: GO:0072594 ! establishment of protein localization to organelle intersection_of: GO:0045184 ! establishment of protein localization intersection_of: RO:0002339 GO:0005694 ! has target end location chromosome relationship: RO:0002339 GO:0005694 ! has target end location chromosome [Term] id: GO:0070201 name: regulation of establishment of protein localization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the directed movement of a protein to a specific location." [GOC:BHF, GOC:mah] synonym: "regulation of establishment of protein localisation" EXACT [GOC:mah] is_a: GO:0032880 ! regulation of protein localization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0045184 ! regulates establishment of protein localization relationship: RO:0002211 GO:0045184 ! regulates establishment of protein localization [Term] id: GO:0070202 name: regulation of establishment of protein localization to chromosome namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the directed movement of a protein to a specific location on a chromosome." [GOC:BHF, GOC:mah] synonym: "regulation of establishment of protein localisation to chromosome" EXACT [GOC:mah] is_a: GO:0070201 ! regulation of establishment of protein localization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0070199 ! regulates establishment of protein localization to chromosome relationship: RO:0002211 GO:0070199 ! regulates establishment of protein localization to chromosome [Term] id: GO:0070227 name: lymphocyte apoptotic process namespace: biological_process def: "Any apoptotic process in a lymphocyte, a leukocyte commonly found in the blood and lymph that has the characteristics of a large nucleus, a neutral staining cytoplasm, and prominent heterochromatin." [CL:0000542, GOC:add, GOC:mtg_apoptosis, ISBN:0781765196] comment: Note that a lymphocyte is a cell of the B cell, T cell, or natural killer cell lineage (CL:0000542). synonym: "lymphocyte apoptosis" NARROW [] is_a: GO:0071887 ! leukocyte apoptotic process intersection_of: GO:0006915 ! apoptotic process intersection_of: BFO:0000066 CL:0000542 ! occurs in lymphocyte relationship: BFO:0000066 CL:0000542 ! occurs in lymphocyte [Term] id: GO:0070228 name: regulation of lymphocyte apoptotic process namespace: biological_process def: "Any process that modulates the occurrence or rate of lymphocyte death by apoptotic process." [GOC:add, GOC:mtg_apoptosis, ISBN:0781765196] comment: Note that a lymphocyte is a cell of the B cell, T cell, or natural killer cell lineage (CL:0000542). synonym: "regulation of lymphocyte apoptosis" NARROW [] is_a: GO:2000106 ! regulation of leukocyte apoptotic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0070227 ! regulates lymphocyte apoptotic process relationship: RO:0002211 GO:0070227 ! regulates lymphocyte apoptotic process [Term] id: GO:0070229 name: negative regulation of lymphocyte apoptotic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of lymphocyte death by apoptotic process." [GOC:add, GOC:mtg_apoptosis, ISBN:0781765196] comment: Note that a lymphocyte is a cell of the B cell, T cell, or natural killer cell lineage (CL:0000542). synonym: "down regulation of lymphocyte apoptosis" EXACT [GOC:add] synonym: "down-regulation of lymphocyte apoptosis" EXACT [GOC:add] synonym: "downregulation of lymphocyte apoptosis" EXACT [GOC:add] synonym: "inhibition of lymphocyte apoptosis" NARROW [GOC:add] synonym: "negative regulation of lymphocyte apoptosis" NARROW [] is_a: GO:0070228 ! regulation of lymphocyte apoptotic process is_a: GO:2000107 ! negative regulation of leukocyte apoptotic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0070227 ! negatively regulates lymphocyte apoptotic process relationship: RO:0002212 GO:0070227 ! negatively regulates lymphocyte apoptotic process [Term] id: GO:0070230 name: positive regulation of lymphocyte apoptotic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of lymphocyte death by apoptotic process." [GOC:add, GOC:mtg_apoptosis, ISBN:0781765196] comment: Note that a lymphocyte is a cell of the B cell, T cell, or natural killer cell lineage (CL:0000542). synonym: "activation of lymphocyte apoptosis" NARROW [GOC:add] synonym: "positive regulation of lymphocyte apoptosis" NARROW [] synonym: "stimulation of lymphocyte apoptosis" NARROW [GOC:add] synonym: "up regulation of lymphocyte apoptosis" EXACT [GOC:add] synonym: "up-regulation of lymphocyte apoptosis" EXACT [GOC:add] synonym: "upregulation of lymphocyte apoptosis" EXACT [GOC:add] is_a: GO:0070228 ! regulation of lymphocyte apoptotic process is_a: GO:2000108 ! positive regulation of leukocyte apoptotic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0070227 ! positively regulates lymphocyte apoptotic process relationship: RO:0002213 GO:0070227 ! positively regulates lymphocyte apoptotic process [Term] id: GO:0070231 name: T cell apoptotic process namespace: biological_process def: "Any apoptotic process in a T cell, a type of lymphocyte whose defining characteristic is the expression of a T cell receptor complex." [CL:0000084, GOC:add, GOC:mtg_apoptosis, ISBN:0781765196] synonym: "programmed cell death of T cells by apoptosis" EXACT [GOC:add] synonym: "T cell apoptosis" NARROW [] synonym: "T lymphocyte apoptosis" EXACT [GOC:add] synonym: "T-cell apoptosis" EXACT [GOC:add] synonym: "T-lymphocyte apoptosis" EXACT [GOC:add] is_a: GO:0070227 ! lymphocyte apoptotic process intersection_of: GO:0006915 ! apoptotic process intersection_of: BFO:0000066 CL:0000084 ! occurs in T cell relationship: BFO:0000066 CL:0000084 ! occurs in T cell [Term] id: GO:0070232 name: regulation of T cell apoptotic process namespace: biological_process def: "Any process that modulates the occurrence or rate of T cell death by apoptotic process." [GOC:add, GOC:mtg_apoptosis, ISBN:0781765196] synonym: "regulation of programmed cell death of T cells by apoptosis" EXACT [GOC:add] synonym: "regulation of T cell apoptosis" NARROW [] synonym: "regulation of T lymphocyte apoptosis" EXACT [GOC:add] synonym: "regulation of T-cell apoptosis" EXACT [GOC:add] synonym: "regulation of T-lymphocyte apoptosis" EXACT [GOC:add] is_a: GO:0070228 ! regulation of lymphocyte apoptotic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0070231 ! regulates T cell apoptotic process relationship: RO:0002211 GO:0070231 ! regulates T cell apoptotic process [Term] id: GO:0070233 name: negative regulation of T cell apoptotic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of T cell death by apoptotic process." [GOC:add, GOC:mtg_apoptosis, ISBN:0781765196] synonym: "down regulation of T cell apoptosis" EXACT [GOC:add] synonym: "down-regulation of T cell apoptosis" EXACT [GOC:add] synonym: "downregulation of T cell apoptosis" EXACT [GOC:add] synonym: "inhibition of T cell apoptosis" NARROW [GOC:add] synonym: "negative regulation of programmed cell death of T cells by apoptosis" EXACT [GOC:add] synonym: "negative regulation of T cell apoptosis" NARROW [] synonym: "negative regulation of T lymphocyte apoptosis" EXACT [GOC:add] synonym: "negative regulation of T-cell apoptosis" EXACT [GOC:add] synonym: "negative regulation of T-lymphocyte apoptosis" EXACT [GOC:add] is_a: GO:0070229 ! negative regulation of lymphocyte apoptotic process is_a: GO:0070232 ! regulation of T cell apoptotic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0070231 ! negatively regulates T cell apoptotic process relationship: RO:0002212 GO:0070231 ! negatively regulates T cell apoptotic process [Term] id: GO:0070234 name: positive regulation of T cell apoptotic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of T cell death by apoptotic process." [GOC:add, GOC:mtg_apoptosis, ISBN:0781765196] synonym: "activation of T cell apoptosis" NARROW [GOC:add] synonym: "positive regulation of programmed cell death of T cells by apoptosis" EXACT [GOC:add] synonym: "positive regulation of T cell apoptosis" NARROW [] synonym: "positive regulation of T lymphocyte apoptosis" EXACT [GOC:add] synonym: "positive regulation of T-cell apoptosis" EXACT [GOC:add] synonym: "positive regulation of T-lymphocyte apoptosis" EXACT [GOC:add] synonym: "stimulation of T cell apoptosis" NARROW [GOC:add] synonym: "up regulation of T cell apoptosis" EXACT [GOC:add] synonym: "up-regulation of T cell apoptosis" EXACT [GOC:add] synonym: "upregulation of T cell apoptosis" EXACT [GOC:add] is_a: GO:0070230 ! positive regulation of lymphocyte apoptotic process is_a: GO:0070232 ! regulation of T cell apoptotic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0070231 ! positively regulates T cell apoptotic process relationship: RO:0002213 GO:0070231 ! positively regulates T cell apoptotic process [Term] id: GO:0070242 name: thymocyte apoptotic process namespace: biological_process def: "Any apoptotic process in a thymocyte, an immature T cell located in the thymus." [CL:0000893, GOC:add, GOC:mtg_apoptosis, ISBN:0781765196] comment: Note that a thymocyte is an immature T cell located in the thymus (CL:0000893). synonym: "immature T cell apoptosis" RELATED [GOC:add] synonym: "thymocyte apoptosis" NARROW [] is_a: GO:0070231 ! T cell apoptotic process intersection_of: GO:0006915 ! apoptotic process intersection_of: BFO:0000066 CL:0000893 ! occurs in thymocyte relationship: BFO:0000066 CL:0000893 ! occurs in thymocyte [Term] id: GO:0070243 name: regulation of thymocyte apoptotic process namespace: biological_process def: "Any process that modulates the occurrence or rate of thymocyte death by apoptotic process." [GOC:add, GOC:mtg_apoptosis, ISBN:0781765196] comment: Note that a thymocyte is an immature T cell located in the thymus (CL:0000893). synonym: "regulation of immature T cell apoptosis" RELATED [GOC:add] synonym: "regulation of thymocyte apoptosis" NARROW [] is_a: GO:0070232 ! regulation of T cell apoptotic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0070242 ! regulates thymocyte apoptotic process relationship: RO:0002211 GO:0070242 ! regulates thymocyte apoptotic process [Term] id: GO:0070244 name: negative regulation of thymocyte apoptotic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of thymocyte death by apoptotic process." [GOC:add, GOC:mtg_apoptosis, ISBN:0781765196] comment: Note that a thymocyte is an immature T cell located in the thymus (CL:0000893). synonym: "down regulation of thymocyte apoptosis" EXACT [GOC:add] synonym: "down-regulation of thymocyte apoptosis" EXACT [GOC:add] synonym: "downregulation of thymocyte apoptosis" EXACT [GOC:add] synonym: "inhibition of thymocyte apoptosis" NARROW [GOC:add] synonym: "negative regulation of immature T cell apoptosis" RELATED [GOC:add] synonym: "negative regulation of thymocyte apoptosis" NARROW [] is_a: GO:0070233 ! negative regulation of T cell apoptotic process is_a: GO:0070243 ! regulation of thymocyte apoptotic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0070242 ! negatively regulates thymocyte apoptotic process relationship: RO:0002212 GO:0070242 ! negatively regulates thymocyte apoptotic process [Term] id: GO:0070245 name: positive regulation of thymocyte apoptotic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of thymocyte death by apoptotic process." [GOC:add, GOC:mtg_apoptosis, ISBN:0781765196] comment: Note that a thymocyte is an immature T cell located in the thymus (CL:0000893). synonym: "activation of thymocyte apoptosis" NARROW [GOC:add] synonym: "positive regulation of immature T cell apoptosis" RELATED [GOC:add] synonym: "positive regulation of thymocyte apoptosis" NARROW [] synonym: "stimulation of thymocyte apoptosis" NARROW [GOC:add] synonym: "up regulation of thymocyte apoptosis" EXACT [GOC:add] synonym: "up-regulation of thymocyte apoptosis" EXACT [GOC:add] synonym: "upregulation of thymocyte apoptosis" EXACT [GOC:add] is_a: GO:0070234 ! positive regulation of T cell apoptotic process is_a: GO:0070243 ! regulation of thymocyte apoptotic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0070242 ! positively regulates thymocyte apoptotic process relationship: RO:0002213 GO:0070242 ! positively regulates thymocyte apoptotic process [Term] id: GO:0070246 name: natural killer cell apoptotic process namespace: biological_process def: "Any apoptotic process in a natural killer cell, a lymphocyte that can spontaneously kill a variety of target cells without prior antigenic activation." [CL:0000623, GOC:add, GOC:mtg_apoptosis, PMID:15728472] synonym: "natural killer cell apoptosis" NARROW [] synonym: "NK cell apoptosis" EXACT [GOC:add] is_a: GO:0070227 ! lymphocyte apoptotic process intersection_of: GO:0006915 ! apoptotic process intersection_of: BFO:0000066 CL:0000623 ! occurs in natural killer cell relationship: BFO:0000066 CL:0000623 ! occurs in natural killer cell [Term] id: GO:0070247 name: regulation of natural killer cell apoptotic process namespace: biological_process def: "Any process that modulates the occurrence or rate of natural killer cell death by apoptotic process." [GOC:add, GOC:mtg_apoptosis, ISBN:0781765196] synonym: "regulation of natural killer cell apoptosis" NARROW [] synonym: "regulation of NK cell apoptosis" EXACT [GOC:add] is_a: GO:0070228 ! regulation of lymphocyte apoptotic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0070246 ! regulates natural killer cell apoptotic process relationship: RO:0002211 GO:0070246 ! regulates natural killer cell apoptotic process [Term] id: GO:0070248 name: negative regulation of natural killer cell apoptotic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of natural killer cell death by apoptotic process." [GOC:add, GOC:mtg_apoptosis, ISBN:0781765196] synonym: "down regulation of natural killer cell apoptosis" EXACT [GOC:add] synonym: "down-regulation of natural killer cell apoptosis" EXACT [GOC:add] synonym: "downregulation of natural killer cell apoptosis" EXACT [GOC:add] synonym: "inhibition of natural killer cell apoptosis" NARROW [GOC:add] synonym: "negative regulation of natural killer cell apoptosis" NARROW [] synonym: "negative regulation of NK cell apoptosis" EXACT [GOC:add] is_a: GO:0070229 ! negative regulation of lymphocyte apoptotic process is_a: GO:0070247 ! regulation of natural killer cell apoptotic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0070246 ! negatively regulates natural killer cell apoptotic process relationship: RO:0002212 GO:0070246 ! negatively regulates natural killer cell apoptotic process [Term] id: GO:0070249 name: positive regulation of natural killer cell apoptotic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of natural killer cell death by apoptotic process." [GOC:add, GOC:mtg_apoptosis, ISBN:0781765196] synonym: "activation of natural killer cell apoptosis" NARROW [GOC:add] synonym: "positive regulation of natural killer cell apoptosis" NARROW [] synonym: "positive regulation of NK cell apoptosis" EXACT [GOC:add] synonym: "stimulation of natural killer cell apoptosis" NARROW [GOC:add] synonym: "up regulation of natural killer cell apoptosis" EXACT [GOC:add] synonym: "up-regulation of natural killer cell apoptosis" EXACT [GOC:add] synonym: "upregulation of natural killer cell apoptosis" EXACT [GOC:add] is_a: GO:0070230 ! positive regulation of lymphocyte apoptotic process is_a: GO:0070247 ! regulation of natural killer cell apoptotic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0070246 ! positively regulates natural killer cell apoptotic process relationship: RO:0002213 GO:0070246 ! positively regulates natural killer cell apoptotic process [Term] id: GO:0070252 name: actin-mediated cell contraction namespace: biological_process def: "The actin filament-based process in which cytoplasmic actin filaments slide past one another resulting in contraction of all or part of the cell body." [GOC:mah] is_a: GO:0030048 ! actin filament-based movement [Term] id: GO:0070253 name: somatostatin secretion namespace: biological_process def: "The regulated release of somatostatin from secretory granules in the D cells of the pancreas." [GOC:mah] is_a: GO:0030072 ! peptide hormone secretion intersection_of: GO:0046903 ! secretion intersection_of: RO:0004009 CHEBI:64628 ! has primary input relationship: RO:0004009 CHEBI:64628 ! has primary input [Term] id: GO:0070254 name: mucus secretion namespace: biological_process def: "The regulated release of mucus by the mucosa. Mucus is a viscous slimy secretion consisting of mucins and various inorganic salts dissolved in water, with suspended epithelial cells and leukocytes. The mucosa, or mucous membrane, is the membrane covered with epithelium that lines the tubular organs of the body. Mucins are carbohydrate-rich glycoproteins that have a lubricating and protective function." [GOC:add, ISBN:068340007X, ISBN:0721662544] synonym: "mucus production" EXACT [GOC:add] is_a: BFO:0000003 is_a: GO:0007589 ! body fluid secretion is_a: GO:0032941 ! secretion by tissue intersection_of: GO:0046903 ! secretion intersection_of: RO:0004009 UBERON:0000912 ! has primary input mucus relationship: RO:0004009 UBERON:0000912 ! has primary input mucus property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0070255 name: regulation of mucus secretion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the regulated release of mucus from a cell or a tissue." [GOC:add] synonym: "regulation of mucus production" EXACT [GOC:add] is_a: GO:0050878 ! regulation of body fluid levels is_a: GO:0051046 ! regulation of secretion is_a: GO:0051239 ! regulation of multicellular organismal process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0070254 ! regulates mucus secretion relationship: RO:0002211 GO:0070254 ! regulates mucus secretion property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0070256 name: negative regulation of mucus secretion namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of mucus from a cell or a tissue." [GOC:add] synonym: "negative regulation of mucus production" EXACT [GOC:add] is_a: GO:0051048 ! negative regulation of secretion is_a: GO:0051241 ! negative regulation of multicellular organismal process is_a: GO:0070255 ! regulation of mucus secretion intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0070254 ! negatively regulates mucus secretion relationship: RO:0002212 GO:0070254 ! negatively regulates mucus secretion property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0070257 name: positive regulation of mucus secretion namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the regulated release of mucus from a cell or a tissue." [GOC:add] synonym: "positive regulation of mucus production" EXACT [GOC:add] is_a: GO:0051047 ! positive regulation of secretion is_a: GO:0051240 ! positive regulation of multicellular organismal process is_a: GO:0070255 ! regulation of mucus secretion intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0070254 ! positively regulates mucus secretion relationship: RO:0002213 GO:0070254 ! positively regulates mucus secretion property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0070278 name: extracellular matrix constituent secretion namespace: biological_process def: "The controlled release of molecules that form the extracellular matrix, including carbohydrates and glycoproteins by a cell." [GOC:mah] synonym: "ECM constituent secretion" EXACT [GOC:mah] synonym: "ECM secretion" EXACT [GOC:mah] is_a: GO:0032940 ! secretion by cell relationship: BFO:0000050 GO:0030198 ! part of extracellular matrix organization [Term] id: GO:0070285 name: pigment cell development namespace: biological_process def: "The process whose specific outcome is the progression of a pigment cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a pigment cell fate." [GOC:cvs] is_a: GO:0048468 ! cell development intersection_of: GO:0032502 ! developmental process intersection_of: RO:0002296 CL:0000147 ! results in development of pigment cell relationship: BFO:0000050 GO:0050931 ! part of pigment cell differentiation relationship: RO:0002296 CL:0000147 ! results in development of pigment cell [Term] id: GO:0070286 name: axonemal dynein complex assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form an axonemal dynein complex, a dynein complex found in eukaryotic cilia and flagella, in which the motor domain heads interact with adjacent microtubules to generate a sliding force which is converted to a bending motion." [GOC:cilia, GOC:mah, PMID:19052621] synonym: "dynein arm assembly" EXACT [GOC:vk, PMID:19944405] is_a: GO:0065003 ! protein-containing complex assembly intersection_of: GO:0022607 ! cellular component assembly intersection_of: RO:0002588 GO:0005858 ! results in assembly of axonemal dynein complex relationship: BFO:0000050 GO:0035082 ! part of axoneme assembly relationship: RO:0002588 GO:0005858 ! results in assembly of axonemal dynein complex property_value: RO:0002161 NCBITaxon:3176 property_value: RO:0002161 NCBITaxon:3378 property_value: RO:0002161 NCBITaxon:3398 property_value: RO:0002161 NCBITaxon:4890 property_value: RO:0002161 NCBITaxon:5782 [Term] id: GO:0070293 name: renal absorption namespace: biological_process def: "A renal system process in which water, ions, glucose and proteins are taken up from the collecting ducts, glomerulus and proximal and distal loops of the nephron. In non-mammalian species, absorption may occur in related structures (e.g. protein absorption is observed in nephrocytes in Drosophila, see PMID:23264686)." [GOC:dph, GOC:mah, GOC:yaf] synonym: "nephron absorption" EXACT [GOC:mah] synonym: "renal reabsorption" EXACT [GOC:dph] is_a: GO:0003014 ! renal system process property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0070295 name: renal water absorption namespace: biological_process def: "A renal system process in which water is taken up from the collecting ducts and proximal and distal loops of the nephron. In non-mammalian species, absorption may occur in related structures." [GOC:dph, GOC:mah] synonym: "nephron water absorption" EXACT [GOC:mah] synonym: "renal water reabsorption" EXACT [GOC:dph] is_a: GO:0003097 ! renal water transport is_a: GO:0070293 ! renal absorption property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0070306 name: lens fiber cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a lens fiber cell, any of the elongated, tightly packed cells that make up the bulk of the mature lens in the camera-type eye. The cytoplasm of a lens fiber cell is devoid of most intracellular organelles including the cell nucleus, and contains primarily crystallins, a group of water-soluble proteins expressed in vary large quantities." [GOC:mah, PMID:7693735] synonym: "lens fibre cell differentiation" EXACT [GOC:mah] is_a: GO:0030855 ! epithelial cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0011004 ! results in acquisition of features of lens fiber cell relationship: BFO:0000050 GO:0002088 ! part of lens development in camera-type eye relationship: RO:0002315 CL:0011004 ! results in acquisition of features of lens fiber cell [Term] id: GO:0070307 name: lens fiber cell development namespace: biological_process def: "The process whose specific outcome is the progression of a lens fiber cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a lens fiber cell fate. A lens fiber cell is any of the elongated, tightly packed cells that make up the bulk of the mature lens in a camera-type eye." [GOC:mah, PMID:7693735] synonym: "lens fibre cell development" EXACT [GOC:mah] is_a: GO:0002064 ! epithelial cell development intersection_of: GO:0048468 ! cell development intersection_of: RO:0002296 CL:0011004 ! results in development of lens fiber cell relationship: BFO:0000050 GO:0070306 ! part of lens fiber cell differentiation relationship: RO:0002296 CL:0011004 ! results in development of lens fiber cell [Term] id: GO:0070341 name: fat cell proliferation namespace: biological_process def: "The multiplication or reproduction of fat cells by cell division, resulting in the expansion of their population. A fat cell is an animal connective tissue cell specialized for the synthesis and storage of fat." [GOC:mah, GOC:sl] synonym: "adipocyte proliferation" EXACT [GOC:sl] synonym: "adipose cell proliferation" EXACT [GOC:sl] is_a: BFO:0000003 is_a: GO:0008283 ! cell population proliferation intersection_of: GO:0008283 ! cell population proliferation intersection_of: RO:0012003 CL:0000136 ! acts on population of adipocyte relationship: RO:0012003 CL:0000136 ! acts on population of adipocyte property_value: RO:0002161 NCBITaxon:4751 [Term] id: GO:0070342 name: brown fat cell proliferation namespace: biological_process def: "The multiplication or reproduction of brown fat cells by cell division, resulting in the expansion of their population. A brown fat cell is a fat cell found the thermogenic form of adipose tissue found in newborns of many species." [CL:0000449, GOC:mah, GOC:sl] synonym: "brown adipocyte proliferation" EXACT [GOC:sl] synonym: "brown adipose cell proliferation" EXACT [GOC:sl] is_a: GO:0070341 ! fat cell proliferation intersection_of: GO:0008283 ! cell population proliferation intersection_of: RO:0012003 CL:0000449 ! acts on population of brown adipocyte relationship: RO:0012003 CL:0000449 ! acts on population of brown adipocyte property_value: RO:0002161 NCBITaxon:4751 property_value: RO:0002161 NCBITaxon:8782 [Term] id: GO:0070343 name: white fat cell proliferation namespace: biological_process def: "The multiplication or reproduction of white fat cells by cell division, resulting in the expansion of their population." [CL:0000448, GOC:mah, GOC:sl] synonym: "white adipocyte proliferation" EXACT [GOC:sl] synonym: "white adipose cell proliferation" EXACT [GOC:sl] is_a: GO:0070341 ! fat cell proliferation intersection_of: GO:0008283 ! cell population proliferation intersection_of: RO:0012003 CL:0000448 ! acts on population of white adipocyte relationship: RO:0012003 CL:0000448 ! acts on population of white adipocyte property_value: RO:0002161 NCBITaxon:4751 [Term] id: GO:0070344 name: regulation of fat cell proliferation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of fat cell proliferation." [GOC:mah, GOC:sl] synonym: "regulation of adipocyte proliferation" EXACT [GOC:sl] synonym: "regulation of adipose cell proliferation" EXACT [GOC:sl] is_a: GO:0042127 ! regulation of cell population proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0070341 ! regulates fat cell proliferation relationship: RO:0002211 GO:0070341 ! regulates fat cell proliferation property_value: RO:0002161 NCBITaxon:4751 [Term] id: GO:0070345 name: negative regulation of fat cell proliferation namespace: biological_process def: "Any process that stops or decreases the rate or extent of fat cell proliferation." [GOC:mah, GOC:sl] synonym: "down regulation of fat cell proliferation" EXACT [GOC:mah] synonym: "down-regulation of fat cell proliferation" EXACT [GOC:mah] synonym: "downregulation of fat cell proliferation" EXACT [GOC:mah] synonym: "inhibition of fat cell proliferation" NARROW [GOC:mah] synonym: "negative regulation of adipocyte proliferation" EXACT [GOC:sl] synonym: "negative regulation of adipose cell proliferation" EXACT [GOC:sl] is_a: GO:0008285 ! negative regulation of cell population proliferation is_a: GO:0070344 ! regulation of fat cell proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0070341 ! negatively regulates fat cell proliferation relationship: RO:0002212 GO:0070341 ! negatively regulates fat cell proliferation property_value: RO:0002161 NCBITaxon:4751 [Term] id: GO:0070346 name: positive regulation of fat cell proliferation namespace: biological_process def: "Any process that activates or increases the rate or extent of fat cell proliferation." [GOC:mah, GOC:sl] synonym: "activation of fat cell proliferation" NARROW [GOC:mah] synonym: "positive regulation of adipocyte proliferation" EXACT [GOC:sl] synonym: "positive regulation of adipose cell proliferation" EXACT [GOC:sl] synonym: "stimulation of fat cell proliferation" NARROW [GOC:mah] synonym: "up regulation of fat cell proliferation" EXACT [GOC:mah] synonym: "up-regulation of fat cell proliferation" EXACT [GOC:mah] synonym: "upregulation of fat cell proliferation" EXACT [GOC:mah] is_a: GO:0008284 ! positive regulation of cell population proliferation is_a: GO:0070344 ! regulation of fat cell proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0070341 ! positively regulates fat cell proliferation relationship: RO:0002213 GO:0070341 ! positively regulates fat cell proliferation property_value: RO:0002161 NCBITaxon:4751 [Term] id: GO:0070347 name: regulation of brown fat cell proliferation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of brown fat cell proliferation." [GOC:mah, GOC:sl] synonym: "regulation of brown adipocyte proliferation" EXACT [GOC:sl] synonym: "regulation of brown adipose cell proliferation" EXACT [GOC:sl] is_a: GO:0070344 ! regulation of fat cell proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0070342 ! regulates brown fat cell proliferation relationship: RO:0002211 GO:0070342 ! regulates brown fat cell proliferation property_value: RO:0002161 NCBITaxon:4751 property_value: RO:0002161 NCBITaxon:8782 [Term] id: GO:0070348 name: negative regulation of brown fat cell proliferation namespace: biological_process def: "Any process that stops or decreases the rate or extent of brown fat cell proliferation." [GOC:mah, GOC:sl] synonym: "down regulation of brown fat cell proliferation" EXACT [GOC:mah] synonym: "down-regulation of brown fat cell proliferation" EXACT [GOC:mah] synonym: "downregulation of brown fat cell proliferation" EXACT [GOC:mah] synonym: "inhibition of brown fat cell proliferation" NARROW [GOC:mah] synonym: "negative regulation of brown adipocyte proliferation" EXACT [GOC:sl] synonym: "negative regulation of brown adipose cell proliferation" EXACT [GOC:sl] is_a: GO:0070345 ! negative regulation of fat cell proliferation is_a: GO:0070347 ! regulation of brown fat cell proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0070342 ! negatively regulates brown fat cell proliferation relationship: RO:0002212 GO:0070342 ! negatively regulates brown fat cell proliferation property_value: RO:0002161 NCBITaxon:4751 property_value: RO:0002161 NCBITaxon:8782 [Term] id: GO:0070349 name: positive regulation of brown fat cell proliferation namespace: biological_process def: "Any process that activates or increases the rate or extent of brown fat cell proliferation." [GOC:mah, GOC:sl] synonym: "activation of brown fat cell proliferation" NARROW [GOC:mah] synonym: "positive regulation of brown adipocyte proliferation" EXACT [GOC:sl] synonym: "positive regulation of brown adipose cell proliferation" EXACT [GOC:sl] synonym: "stimulation of brown fat cell proliferation" NARROW [GOC:mah] synonym: "up regulation of brown fat cell proliferation" EXACT [GOC:mah] synonym: "up-regulation of brown fat cell proliferation" EXACT [GOC:mah] synonym: "upregulation of brown fat cell proliferation" EXACT [GOC:mah] is_a: GO:0070346 ! positive regulation of fat cell proliferation is_a: GO:0070347 ! regulation of brown fat cell proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0070342 ! positively regulates brown fat cell proliferation relationship: RO:0002213 GO:0070342 ! positively regulates brown fat cell proliferation property_value: RO:0002161 NCBITaxon:4751 property_value: RO:0002161 NCBITaxon:8782 [Term] id: GO:0070350 name: regulation of white fat cell proliferation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of white fat cell proliferation." [GOC:mah, GOC:sl] synonym: "regulation of white adipocyte proliferation" EXACT [GOC:sl] synonym: "regulation of white adipose cell proliferation" EXACT [GOC:sl] is_a: GO:0070344 ! regulation of fat cell proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0070343 ! regulates white fat cell proliferation relationship: RO:0002211 GO:0070343 ! regulates white fat cell proliferation property_value: RO:0002161 NCBITaxon:4751 [Term] id: GO:0070351 name: negative regulation of white fat cell proliferation namespace: biological_process def: "Any process that stops or decreases the rate or extent of white fat cell proliferation." [GOC:mah, GOC:sl] synonym: "down regulation of white fat cell proliferation" EXACT [GOC:mah] synonym: "down-regulation of white fat cell proliferation" EXACT [GOC:mah] synonym: "downregulation of white fat cell proliferation" EXACT [GOC:mah] synonym: "inhibition of white fat cell proliferation" NARROW [GOC:mah] synonym: "negative regulation of white adipocyte proliferation" EXACT [GOC:sl] synonym: "negative regulation of white adipose cell proliferation" EXACT [GOC:sl] is_a: GO:0070345 ! negative regulation of fat cell proliferation is_a: GO:0070350 ! regulation of white fat cell proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0070343 ! negatively regulates white fat cell proliferation relationship: RO:0002212 GO:0070343 ! negatively regulates white fat cell proliferation property_value: RO:0002161 NCBITaxon:4751 [Term] id: GO:0070352 name: positive regulation of white fat cell proliferation namespace: biological_process def: "Any process that activates or increases the rate or extent of white fat cell proliferation." [GOC:mah, GOC:sl] synonym: "activation of white fat cell proliferation" NARROW [GOC:mah] synonym: "positive regulation of white adipocyte proliferation" EXACT [GOC:sl] synonym: "positive regulation of white adipose cell proliferation" EXACT [GOC:sl] synonym: "stimulation of white fat cell proliferation" NARROW [GOC:mah] synonym: "up regulation of white fat cell proliferation" EXACT [GOC:mah] synonym: "up-regulation of white fat cell proliferation" EXACT [GOC:mah] synonym: "upregulation of white fat cell proliferation" EXACT [GOC:mah] is_a: GO:0070346 ! positive regulation of fat cell proliferation is_a: GO:0070350 ! regulation of white fat cell proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0070343 ! positively regulates white fat cell proliferation relationship: RO:0002213 GO:0070343 ! positively regulates white fat cell proliferation property_value: RO:0002161 NCBITaxon:4751 [Term] id: GO:0070365 name: hepatocyte differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires the specialized features of a hepatocyte. A hepatocyte is specialized epithelial cell that is organized into interconnected plates called lobules, and is the main structural component of the liver." [CL:0000182, PMID:7588884] synonym: "liver cell differentiation" EXACT [GOC:mah] is_a: GO:0030855 ! epithelial cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000182 ! results in acquisition of features of hepatocyte relationship: BFO:0000050 GO:0001889 ! part of liver development relationship: RO:0002315 CL:0000182 ! results in acquisition of features of hepatocyte [Term] id: GO:0070366 name: regulation of hepatocyte differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of hepatocyte differentiation." [GOC:mah, GOC:sl] synonym: "regulation of liver cell differentiation" EXACT [GOC:sl] is_a: GO:0030856 ! regulation of epithelial cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0070365 ! regulates hepatocyte differentiation relationship: RO:0002211 GO:0070365 ! regulates hepatocyte differentiation [Term] id: GO:0070367 name: negative regulation of hepatocyte differentiation namespace: biological_process def: "Any process that stops or decreases the rate or extent of hepatocyte differentiation." [GOC:mah, GOC:sl] synonym: "down regulation of hepatocyte differentiation" EXACT [GOC:mah] synonym: "down-regulation of hepatocyte differentiation" EXACT [GOC:mah] synonym: "downregulation of hepatocyte differentiation" EXACT [GOC:mah] synonym: "inhibition of hepatocyte differentiation" NARROW [GOC:mah] synonym: "negative regulation of liver cell differentiation" EXACT [GOC:sl] is_a: GO:0030857 ! negative regulation of epithelial cell differentiation is_a: GO:0051241 ! negative regulation of multicellular organismal process is_a: GO:0070366 ! regulation of hepatocyte differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0070365 ! negatively regulates hepatocyte differentiation relationship: RO:0002212 GO:0070365 ! negatively regulates hepatocyte differentiation [Term] id: GO:0070368 name: positive regulation of hepatocyte differentiation namespace: biological_process def: "Any process that activates or increases the rate or extent of hepatocyte differentiation." [GOC:mah, GOC:sl] synonym: "activation of hepatocyte differentiation" NARROW [GOC:mah] synonym: "positive regulation of liver cell differentiation" EXACT [GOC:sl] synonym: "stimulation of hepatocyte differentiation" NARROW [GOC:mah] synonym: "up regulation of hepatocyte differentiation" EXACT [GOC:mah] synonym: "up-regulation of hepatocyte differentiation" EXACT [GOC:mah] synonym: "upregulation of hepatocyte differentiation" EXACT [GOC:mah] is_a: GO:0030858 ! positive regulation of epithelial cell differentiation is_a: GO:0051240 ! positive regulation of multicellular organismal process is_a: GO:0070366 ! regulation of hepatocyte differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0070365 ! positively regulates hepatocyte differentiation relationship: RO:0002213 GO:0070365 ! positively regulates hepatocyte differentiation [Term] id: GO:0070382 name: exocytic vesicle namespace: cellular_component def: "A transport vesicle that mediates transport from an intracellular compartment to the plasma membrane, and fuses with the plasma membrane to release various cargo molecules, such as proteins or hormones, by exocytosis." [GOC:kad, GOC:mah] synonym: "exocytic constitutive secretory pathway transport vesicle" EXACT [] synonym: "exocytotic vesicle" EXACT [GOC:kad] is_a: GO:0030133 ! transport vesicle is_a: GO:0099503 ! secretory vesicle intersection_of: GO:0030133 ! transport vesicle intersection_of: RO:0002215 GO:0099500 ! capable of vesicle fusion to plasma membrane [Term] id: GO:0070405 name: ammonium ion binding namespace: molecular_function def: "Binding to ammonium ions (NH4+)." [CHEBI:28938, GOC:ecd] synonym: "ammonium binding" RELATED [] is_a: GO:0043169 ! cation binding intersection_of: GO:0005488 ! binding intersection_of: RO:0004009 CHEBI:28938 ! has primary input relationship: RO:0004009 CHEBI:28938 ! has primary input [Term] id: GO:0070444 name: oligodendrocyte progenitor proliferation namespace: biological_process def: "The multiplication or reproduction of oligodendrocyte progenitor cells by cell division, resulting in the expansion of their population. Oligodendrocyte progenitors give rise to oligodendrocytes, which form the insulating myelin sheath of axons in the central nervous system." [GOC:mah, GOC:sl, PMID:15504915] synonym: "oligodendrocyte precursor proliferation" EXACT [GOC:mah] is_a: BFO:0000003 is_a: GO:0061351 ! neural precursor cell proliferation intersection_of: GO:0008283 ! cell population proliferation intersection_of: RO:0012003 CL:0002453 ! acts on population of oligodendrocyte precursor cell relationship: BFO:0000050 GO:0042063 ! part of gliogenesis relationship: RO:0012003 CL:0002453 ! acts on population of oligodendrocyte precursor cell [Term] id: GO:0070445 name: regulation of oligodendrocyte progenitor proliferation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of oligodendrocyte progenitor proliferation." [GOC:mah, GOC:sl] synonym: "regulation of oligodendrocyte precursor proliferation" EXACT [GOC:mah] is_a: GO:2000177 ! regulation of neural precursor cell proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0070444 ! regulates oligodendrocyte progenitor proliferation relationship: RO:0002211 GO:0070444 ! regulates oligodendrocyte progenitor proliferation [Term] id: GO:0070446 name: negative regulation of oligodendrocyte progenitor proliferation namespace: biological_process def: "Any process that stops or decreases the rate or extent of oligodendrocyte progenitor proliferation." [GOC:mah, GOC:sl] synonym: "negative regulation of oligodendrocyte precursor proliferation" EXACT [GOC:mah] is_a: GO:0014014 ! negative regulation of gliogenesis is_a: GO:0070445 ! regulation of oligodendrocyte progenitor proliferation is_a: GO:2000178 ! negative regulation of neural precursor cell proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0070444 ! negatively regulates oligodendrocyte progenitor proliferation relationship: RO:0002212 GO:0070444 ! negatively regulates oligodendrocyte progenitor proliferation [Term] id: GO:0070447 name: positive regulation of oligodendrocyte progenitor proliferation namespace: biological_process def: "Any process that activates or increases the rate or extent of oligodendrocyte progenitor proliferation." [GOC:mah, GOC:sl] synonym: "positive regulation of oligodendrocyte precursor proliferation" EXACT [GOC:mah] is_a: GO:0014015 ! positive regulation of gliogenesis is_a: GO:0070445 ! regulation of oligodendrocyte progenitor proliferation is_a: GO:2000179 ! positive regulation of neural precursor cell proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0070444 ! positively regulates oligodendrocyte progenitor proliferation relationship: RO:0002213 GO:0070444 ! positively regulates oligodendrocyte progenitor proliferation [Term] id: GO:0070451 name: cell hair namespace: cellular_component def: "A long, thin cell projection that contains F-actin and tubulin, with microtubules centrally located and F-actin peripherally located." [PMID:11526084] synonym: "imaginal disc-derived wing hair" NARROW [GOC:mah] synonym: "non-sensory hair" EXACT [GOC:bf] xref: Wikipedia:Membrane_nanotube is_a: GO:0120025 ! plasma membrane bounded cell projection [Term] id: GO:0070459 name: prolactin secretion namespace: biological_process def: "The regulated release of prolactin, a peptide hormone that stimulates lactation, from secretory granules in the anterior pituitary." [GOC:mah, ISBN:0198506732] is_a: GO:0009306 ! protein secretion is_a: GO:0030072 ! peptide hormone secretion intersection_of: GO:0046903 ! secretion intersection_of: RO:0004009 PR:000013246 ! has primary input prolactin relationship: RO:0004009 PR:000013246 ! has primary input prolactin [Term] id: GO:0070460 name: thyroid-stimulating hormone secretion namespace: biological_process def: "The regulated release of thyroid-stimulating hormone, a peptide hormone that stimulates the activity of the thyroid gland, from secretory granules in the anterior pituitary." [GOC:mah, ISBN:0198506732] synonym: "thyroid stimulating hormone secretion" EXACT [GOC:mah] synonym: "TSH secretion" EXACT [] is_a: GO:0030072 ! peptide hormone secretion [Term] id: GO:0070482 name: response to oxygen levels namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of oxygen." [GOC:BHF, GOC:mah] is_a: GO:0009628 ! response to abiotic stimulus [Term] id: GO:0070483 name: detection of hypoxia namespace: biological_process def: "The series of events in which a stimulus indicating lowered oxygen tension is received by a cell and converted into a molecular signal. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level." [GOC:BHF, GOC:mah] synonym: "detection of reduced oxygen levels" EXACT [GOC:vk] is_a: GO:0001666 ! response to hypoxia is_a: GO:0003032 ! detection of oxygen [Term] id: GO:0070507 name: regulation of microtubule cytoskeleton organization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins." [GOC:mah] synonym: "regulation of microtubule cytoskeleton organisation" EXACT [GOC:mah] synonym: "regulation of microtubule dynamics" EXACT [GOC:dph, GOC:tb] is_a: GO:0032886 ! regulation of microtubule-based process is_a: GO:0051493 ! regulation of cytoskeleton organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0000226 ! regulates microtubule cytoskeleton organization relationship: RO:0002211 GO:0000226 ! regulates microtubule cytoskeleton organization [Term] id: GO:0070509 name: calcium ion import namespace: biological_process def: "The directed movement of calcium ions into a cell or organelle." [GOC:mah] synonym: "calcium ion uptake" EXACT [GOC:mah] synonym: "transmembrane calcium influx" RELATED [GOC:tb] is_a: GO:0006816 ! calcium ion transport property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/23015" xsd:anyURI [Term] id: GO:0070542 name: response to fatty acid namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a fatty acid stimulus." [GOC:lp] is_a: GO:0033993 ! response to lipid is_a: GO:1901700 ! response to oxygen-containing compound intersection_of: GO:0050896 ! response to stimulus intersection_of: RO:0004009 CHEBI:28868 ! has primary input relationship: RO:0004009 CHEBI:28868 ! has primary input [Term] id: GO:0070560 name: protein secretion by platelet namespace: biological_process def: "The regulated release of proteins by a platelet or group of platelets." [GOC:BHF, GOC:mah] is_a: GO:0009306 ! protein secretion is_a: GO:0051649 ! establishment of localization in cell is_a: GO:0140029 ! exocytic process intersection_of: GO:0009306 ! protein secretion intersection_of: RO:0002608 CL:0000233 ! process has causal agent platelet relationship: BFO:0000050 GO:0002576 ! part of platelet degranulation relationship: RO:0002608 CL:0000233 ! process has causal agent platelet creation_date: 2009-04-09T02:38:05Z [Term] id: GO:0070585 name: protein localization to mitochondrion namespace: biological_process def: "A process in which a protein is transported to, or maintained in, a location within the mitochondrion." [GOC:ecd] synonym: "protein localisation in mitochondrion" EXACT [GOC:mah] synonym: "protein localization in mitochondrion" EXACT [] is_a: GO:0033365 ! protein localization to organelle intersection_of: GO:0008104 ! intracellular protein localization intersection_of: RO:0002339 GO:0005739 ! has target end location mitochondrion relationship: RO:0002339 GO:0005739 ! has target end location mitochondrion creation_date: 2009-04-24T02:31:18Z [Term] id: GO:0070586 name: cell-cell adhesion involved in gastrulation namespace: biological_process def: "The attachment of one cell to another cell affecting gastrulation." [GOC:dsf, PMID:19091770] is_a: GO:0098609 ! cell-cell adhesion intersection_of: GO:0098609 ! cell-cell adhesion intersection_of: BFO:0000050 GO:0007369 ! part of gastrulation relationship: BFO:0000050 GO:0007369 ! part of gastrulation creation_date: 2009-04-24T02:48:23Z [Term] id: GO:0070587 name: regulation of cell-cell adhesion involved in gastrulation namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of attachment of a cell to another cell affecting gastrulation." [GOC:dsf, PMID:19091770] is_a: GO:0022407 ! regulation of cell-cell adhesion intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0070586 ! regulates cell-cell adhesion involved in gastrulation relationship: RO:0002211 GO:0070586 ! regulates cell-cell adhesion involved in gastrulation creation_date: 2009-04-24T02:51:07Z [Term] id: GO:0070588 name: calcium ion transmembrane transport namespace: biological_process def: "A process in which a calcium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:mah] comment: Note that this term is not intended for use in annotating lateral movement within membranes. synonym: "calcium ion membrane transport" EXACT [] synonym: "transmembrane calcium transport" EXACT [GOC:mah] xref: Reactome:R-HSA-3295583 "TRP channels" is_a: GO:0006816 ! calcium ion transport is_a: GO:0098655 ! monoatomic cation transmembrane transport intersection_of: GO:0055085 ! transmembrane transport intersection_of: RO:0004009 CHEBI:29108 ! has primary input creation_date: 2009-04-28T10:44:09Z [Term] id: GO:0070613 name: regulation of protein processing namespace: biological_process def: "Any process that modulates the frequency, rate or extent of protein processing, a protein maturation process achieved by the cleavage of a peptide bond or bonds within a protein." [GOC:mah] synonym: "regulation of protein maturation by peptide bond cleavage" EXACT [] is_a: GO:0030162 ! regulation of proteolysis is_a: GO:1903317 ! regulation of protein maturation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0016485 ! regulates protein processing relationship: RO:0002211 GO:0016485 ! regulates protein processing creation_date: 2009-04-29T02:49:14Z [Term] id: GO:0070633 name: transepithelial transport namespace: biological_process def: "The directed movement of a substance from one side of an epithelium to the other." [GOC:mah, GOC:yaf, ISBN:0716731363] is_a: BFO:0000003 is_a: GO:0006810 ! transport intersection_of: GO:0006810 ! transport intersection_of: RO:0002342 UBERON:0000483 ! results in transport across epithelium relationship: RO:0002342 UBERON:0000483 ! results in transport across epithelium creation_date: 2009-05-06T03:31:02Z [Term] id: GO:0070634 name: transepithelial ammonium transport namespace: biological_process def: "The directed movement of ammonium ions from one side of an epithelium to the other." [GOC:mah, GOC:yaf] is_a: GO:0070633 ! transepithelial transport is_a: GO:0071705 ! nitrogen compound transport intersection_of: GO:0070633 ! transepithelial transport intersection_of: RO:0004009 CHEBI:28938 ! has primary input relationship: RO:0004009 CHEBI:28938 ! has primary input creation_date: 2009-05-06T03:34:43Z [Term] id: GO:0070661 name: leukocyte proliferation namespace: biological_process def: "The expansion of a leukocyte population by cell division." [GOC:add] is_a: BFO:0000003 is_a: GO:0008283 ! cell population proliferation intersection_of: GO:0008283 ! cell population proliferation intersection_of: RO:0012003 CL:0000738 ! acts on population of leukocyte relationship: RO:0002162 NCBITaxon:7742 ! in taxon Vertebrata relationship: RO:0012003 CL:0000738 ! acts on population of leukocyte creation_date: 2009-05-28T05:25:28Z [Term] id: GO:0070662 name: mast cell proliferation namespace: biological_process def: "The expansion of a mast cell population by cell division." [GOC:add] is_a: GO:0070661 ! leukocyte proliferation intersection_of: GO:0008283 ! cell population proliferation intersection_of: RO:0012003 CL:0000097 ! acts on population of mast cell relationship: RO:0012003 CL:0000097 ! acts on population of mast cell creation_date: 2009-05-28T05:27:51Z [Term] id: GO:0070663 name: regulation of leukocyte proliferation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of leukocyte proliferation." [GOC:add, GOC:mah] is_a: GO:0042127 ! regulation of cell population proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0070661 ! regulates leukocyte proliferation relationship: RO:0002211 GO:0070661 ! regulates leukocyte proliferation creation_date: 2009-05-28T05:30:39Z [Term] id: GO:0070664 name: negative regulation of leukocyte proliferation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of leukocyte proliferation." [GOC:add, GOC:mah] synonym: "down regulation of leukocyte proliferation" EXACT [GOC:mah] synonym: "down-regulation of leukocyte proliferation" EXACT [GOC:mah] synonym: "downregulation of leukocyte proliferation" EXACT [GOC:mah] synonym: "inhibition of leukocyte proliferation" NARROW [GOC:mah] is_a: GO:0008285 ! negative regulation of cell population proliferation is_a: GO:0070663 ! regulation of leukocyte proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0070661 ! negatively regulates leukocyte proliferation relationship: RO:0002212 GO:0070661 ! negatively regulates leukocyte proliferation creation_date: 2009-05-28T05:34:50Z [Term] id: GO:0070665 name: positive regulation of leukocyte proliferation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of leukocyte proliferation." [GOC:add, GOC:mah] synonym: "activation of leukocyte proliferation" NARROW [GOC:mah] synonym: "stimulation of leukocyte proliferation" NARROW [GOC:mah] synonym: "up regulation of leukocyte proliferation" EXACT [GOC:mah] synonym: "up-regulation of leukocyte proliferation" EXACT [GOC:mah] synonym: "upregulation of leukocyte proliferation" EXACT [GOC:mah] is_a: GO:0008284 ! positive regulation of cell population proliferation is_a: GO:0070663 ! regulation of leukocyte proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0070661 ! positively regulates leukocyte proliferation relationship: RO:0002213 GO:0070661 ! positively regulates leukocyte proliferation creation_date: 2009-05-28T05:36:46Z [Term] id: GO:0070666 name: regulation of mast cell proliferation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of mast cell proliferation." [GOC:add, GOC:mah] is_a: GO:0070663 ! regulation of leukocyte proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0070662 ! regulates mast cell proliferation relationship: RO:0002211 GO:0070662 ! regulates mast cell proliferation creation_date: 2009-05-28T05:40:43Z [Term] id: GO:0070667 name: negative regulation of mast cell proliferation namespace: biological_process def: "Any process that stops, prevents or reduces the rate or extent of mast cell proliferation." [GOC:add, GOC:mah] synonym: "down regulation of mast cell proliferation" EXACT [GOC:mah] synonym: "down-regulation of mast cell proliferation" EXACT [GOC:mah] synonym: "downregulation of mast cell proliferation" EXACT [GOC:mah] synonym: "inhibition of mast cell proliferation" NARROW [GOC:mah] is_a: GO:0070664 ! negative regulation of leukocyte proliferation is_a: GO:0070666 ! regulation of mast cell proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0070662 ! negatively regulates mast cell proliferation relationship: RO:0002212 GO:0070662 ! negatively regulates mast cell proliferation creation_date: 2009-05-28T05:45:11Z [Term] id: GO:0070668 name: positive regulation of mast cell proliferation namespace: biological_process def: "Any process that activates or increases the rate or extent of mast cell proliferation." [GOC:add, GOC:mah] synonym: "activation of mast cell proliferation" NARROW [GOC:mah] synonym: "stimulation of mast cell proliferation" NARROW [GOC:mah] synonym: "up regulation of mast cell proliferation" EXACT [GOC:mah] synonym: "up-regulation of mast cell proliferation" EXACT [GOC:mah] synonym: "upregulation of mast cell proliferation" EXACT [GOC:mah] is_a: GO:0070665 ! positive regulation of leukocyte proliferation is_a: GO:0070666 ! regulation of mast cell proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0070662 ! positively regulates mast cell proliferation relationship: RO:0002213 GO:0070662 ! positively regulates mast cell proliferation creation_date: 2009-05-28T05:48:30Z [Term] id: GO:0070820 name: tertiary granule namespace: cellular_component def: "A secretory granule that contains cathepsin and gelatinase and is readily exocytosed upon cell activation; found primarily in mature neutrophil cells." [GOC:BHF, GOC:mah, GOC:rl, PMID:12070036] synonym: "gelatinase granule" EXACT [PMID:23650620] is_a: GO:0030141 ! secretory granule property_value: RO:0002161 NCBITaxon:4890 creation_date: 2009-07-20T03:57:00Z [Term] id: GO:0070821 name: tertiary granule membrane namespace: cellular_component def: "The lipid bilayer surrounding a tertiary granule." [GOC:BHF, GOC:mah, GOC:rl, PMID:12070036] is_a: GO:0030667 ! secretory granule membrane intersection_of: GO:0016020 ! membrane intersection_of: RO:0002007 GO:0070820 ! bounding layer of tertiary granule relationship: RO:0002007 GO:0070820 ! bounding layer of tertiary granule property_value: RO:0002161 NCBITaxon:4890 creation_date: 2009-07-20T03:59:41Z [Term] id: GO:0070828 name: heterochromatin organization namespace: biological_process def: "Any process that results in the specification, formation or maintenance of the physical structure of eukaryotic heterochromatin, a compact and highly condensed form of chromatin." [GOC:mah] synonym: "heterochromatin organisation" EXACT [GOC:mah] is_a: GO:0006325 ! chromatin organization intersection_of: GO:0016043 ! cellular component organization intersection_of: RO:0002592 GO:0000792 ! results in organization of heterochromatin relationship: RO:0002592 GO:0000792 ! results in organization of heterochromatin property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/26702" xsd:anyURI creation_date: 2009-07-23T04:12:48Z [Term] id: GO:0070830 name: bicellular tight junction assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form a tight junction, an occluding cell-cell junction that is composed of a branching network of sealing strands that completely encircles the apical end of each cell in an epithelial sheet." [GOC:mah] synonym: "tight junction formation" EXACT [GOC:mah] xref: Reactome:R-HSA-420029 "Tight junction interactions" is_a: GO:0120192 ! tight junction assembly intersection_of: GO:0022607 ! cellular component assembly intersection_of: RO:0002588 GO:0005923 ! results in assembly of bicellular tight junction relationship: BFO:0000050 GO:0043297 ! part of apical junction assembly relationship: RO:0002588 GO:0005923 ! results in assembly of bicellular tight junction property_value: RO:0002161 NCBITaxon:4751 creation_date: 2009-07-23T04:32:38Z [Term] id: GO:0070831 name: basement membrane assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form a basement membrane, a part of the extracellular region that consists of a thin layer of dense material found in various animal tissues interposed between the cells and the adjacent connective tissue." [GOC:mah] comment: Note that this term has no relationship to 'membrane assembly ; GO:0071709' because the basement membrane is not a lipid bilayer. is_a: GO:0071711 ! basement membrane organization is_a: GO:0085029 ! extracellular matrix assembly intersection_of: GO:0022607 ! cellular component assembly intersection_of: RO:0002588 GO:0005604 ! results in assembly of basement membrane relationship: RO:0002588 GO:0005604 ! results in assembly of basement membrane creation_date: 2009-07-23T05:01:51Z [Term] id: GO:0070840 name: dynein complex binding namespace: molecular_function def: "Binding to a dynein complex, a protein complex that contains two or three dynein heavy chains and several light chains, and has microtubule motor activity." [GOC:bf, GOC:BHF, GOC:mah] synonym: "dynein binding" RELATED [] is_a: GO:0044877 ! protein-containing complex binding intersection_of: GO:0005488 ! binding intersection_of: RO:0004009 GO:0030286 ! has primary input dynein complex relationship: RO:0004009 GO:0030286 ! has primary input dynein complex creation_date: 2009-07-31T01:22:47Z [Term] id: GO:0070851 name: growth factor receptor binding namespace: molecular_function def: "Binding to a growth factor receptor." [GOC:mah, GOC:vw] is_a: GO:0005102 ! signaling receptor binding creation_date: 2009-08-07T11:23:02Z [Term] id: GO:0070857 name: regulation of bile acid biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of bile acids." [GOC:BHF, GOC:mah] synonym: "regulation of bile acid anabolism" EXACT [GOC:mah] synonym: "regulation of bile acid biosynthesis" EXACT [GOC:mah] synonym: "regulation of bile acid formation" EXACT [GOC:mah] synonym: "regulation of bile acid synthesis" EXACT [GOC:mah] is_a: GO:0010565 ! regulation of ketone metabolic process is_a: GO:0050810 ! regulation of steroid biosynthetic process is_a: GO:0062012 ! regulation of small molecule metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0006699 ! regulates bile acid biosynthetic process relationship: RO:0002211 GO:0006699 ! regulates bile acid biosynthetic process creation_date: 2009-08-14T03:09:02Z [Term] id: GO:0070858 name: negative regulation of bile acid biosynthetic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of bile acids." [GOC:BHF, GOC:mah] synonym: "down regulation of bile acid biosynthetic process" EXACT [GOC:mah] synonym: "down-regulation of bile acid biosynthetic process" EXACT [GOC:mah] synonym: "downregulation of bile acid biosynthetic process" EXACT [GOC:mah] synonym: "inhibition of bile acid biosynthetic process" NARROW [GOC:mah] synonym: "negative regulation of bile acid anabolism" EXACT [GOC:mah] synonym: "negative regulation of bile acid biosynthesis" EXACT [GOC:mah] synonym: "negative regulation of bile acid formation" EXACT [GOC:mah] synonym: "negative regulation of bile acid synthesis" EXACT [GOC:mah] is_a: GO:0010894 ! negative regulation of steroid biosynthetic process is_a: GO:0062014 ! negative regulation of small molecule metabolic process is_a: GO:0070857 ! regulation of bile acid biosynthetic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0006699 ! negatively regulates bile acid biosynthetic process relationship: RO:0002212 GO:0006699 ! negatively regulates bile acid biosynthetic process creation_date: 2009-08-14T03:16:40Z [Term] id: GO:0070859 name: positive regulation of bile acid biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of bile acids." [GOC:BHF, GOC:mah] synonym: "activation of bile acid biosynthetic process" NARROW [GOC:mah] synonym: "positive regulation of bile acid anabolism" EXACT [GOC:mah] synonym: "positive regulation of bile acid biosynthesis" EXACT [GOC:mah] synonym: "positive regulation of bile acid formation" EXACT [GOC:mah] synonym: "positive regulation of bile acid synthesis" EXACT [GOC:mah] synonym: "stimulation of bile acid biosynthetic process" NARROW [GOC:mah] synonym: "up regulation of bile acid biosynthetic process" EXACT [GOC:mah] synonym: "up-regulation of bile acid biosynthetic process" EXACT [GOC:mah] synonym: "upregulation of bile acid biosynthetic process" EXACT [GOC:mah] is_a: GO:0010893 ! positive regulation of steroid biosynthetic process is_a: GO:0062013 ! positive regulation of small molecule metabolic process is_a: GO:0070857 ! regulation of bile acid biosynthetic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0006699 ! positively regulates bile acid biosynthetic process relationship: RO:0002213 GO:0006699 ! positively regulates bile acid biosynthetic process creation_date: 2009-08-14T03:22:58Z [Term] id: GO:0070873 name: regulation of glycogen metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving glycogen." [GOC:mah] synonym: "regulation of glycogen metabolism" EXACT [GOC:mah] is_a: GO:0032881 ! regulation of polysaccharide metabolic process is_a: GO:0043467 ! regulation of generation of precursor metabolites and energy intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0005977 ! regulates glycogen metabolic process relationship: RO:0002211 GO:0005977 ! regulates glycogen metabolic process creation_date: 2009-08-20T02:44:53Z [Term] id: GO:0070874 name: negative regulation of glycogen metabolic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving glycogen." [GOC:mah] synonym: "negative regulation of glycogen metabolism" EXACT [GOC:mah] is_a: GO:0010605 ! negative regulation of macromolecule metabolic process is_a: GO:0045912 ! negative regulation of carbohydrate metabolic process is_a: GO:0070873 ! regulation of glycogen metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0005977 ! negatively regulates glycogen metabolic process relationship: RO:0002212 GO:0005977 ! negatively regulates glycogen metabolic process creation_date: 2009-08-20T02:50:41Z [Term] id: GO:0070875 name: positive regulation of glycogen metabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving glycogen." [GOC:mah] synonym: "positive regulation of glycogen metabolism" EXACT [GOC:mah] is_a: GO:0010604 ! positive regulation of macromolecule metabolic process is_a: GO:0010907 ! positive regulation of glucose metabolic process is_a: GO:0070873 ! regulation of glycogen metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0005977 ! positively regulates glycogen metabolic process relationship: RO:0002213 GO:0005977 ! positively regulates glycogen metabolic process creation_date: 2009-08-20T02:53:55Z [Term] id: GO:0070887 name: cellular response to chemical stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chemical stimulus." [GOC:mah] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_annotate is_a: GO:0042221 ! response to chemical is_a: GO:0051716 ! cellular response to stimulus creation_date: 2009-08-27T04:41:45Z [Term] id: GO:0070925 name: organelle assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form an organelle. An organelle is an organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane." [GOC:mah] subset: gocheck_do_not_annotate subset: goslim_yeast is_a: GO:0006996 ! organelle organization is_a: GO:0022607 ! cellular component assembly intersection_of: GO:0022607 ! cellular component assembly intersection_of: RO:0002588 GO:0043226 ! results in assembly of organelle relationship: RO:0002588 GO:0043226 ! results in assembly of organelle creation_date: 2009-09-15T03:00:51Z [Term] id: GO:0070942 name: neutrophil mediated cytotoxicity namespace: biological_process def: "The directed killing of a target cell by a neutrophil." [GOC:add, ISBN:0781765196] synonym: "neutrophil mediated cell killing" EXACT [GOC:add] is_a: GO:0001909 ! leukocyte mediated cytotoxicity is_a: GO:0002446 ! neutrophil mediated immunity intersection_of: GO:0001906 ! cell killing intersection_of: RO:0002608 CL:0000775 ! process has causal agent neutrophil creation_date: 2009-10-01T01:49:30Z [Term] id: GO:0070948 name: regulation of neutrophil mediated cytotoxicity namespace: biological_process def: "Any process that modulates the rate, frequency or extent of neutrophil mediated killing of a target cell, the directed killing of a target cell by a neutrophil." [GOC:add, GOC:mah] synonym: "regulation of neutrophil mediated cell killing" EXACT [GOC:add] is_a: GO:0001910 ! regulation of leukocyte mediated cytotoxicity is_a: GO:0002886 ! regulation of myeloid leukocyte mediated immunity intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0070942 ! regulates neutrophil mediated cytotoxicity relationship: RO:0002211 GO:0070942 ! regulates neutrophil mediated cytotoxicity creation_date: 2009-10-01T02:14:36Z [Term] id: GO:0070954 name: negative regulation of neutrophil mediated cytotoxicity namespace: biological_process def: "Any process that decreases the frequency, rate or extent of the directed killing of a target cell by a neutrophil." [GOC:add, GOC:mah] synonym: "down regulation of neutrophil mediated cytotoxicity" EXACT [GOC:mah] synonym: "down-regulation of neutrophil mediated cytotoxicity" EXACT [GOC:mah] synonym: "downregulation of neutrophil mediated cytotoxicity" EXACT [GOC:mah] synonym: "inhibition of neutrophil mediated cytotoxicity" NARROW [GOC:mah] synonym: "negative regulation of neutrophil mediated cell killing" EXACT [GOC:add] is_a: GO:0001911 ! negative regulation of leukocyte mediated cytotoxicity is_a: GO:0002887 ! negative regulation of myeloid leukocyte mediated immunity is_a: GO:0070948 ! regulation of neutrophil mediated cytotoxicity intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0070942 ! negatively regulates neutrophil mediated cytotoxicity relationship: RO:0002212 GO:0070942 ! negatively regulates neutrophil mediated cytotoxicity creation_date: 2009-10-01T02:20:17Z [Term] id: GO:0070960 name: positive regulation of neutrophil mediated cytotoxicity namespace: biological_process def: "Any process that increases the frequency, rate or extent of the directed killing of a target cell by a neutrophil." [GOC:add, GOC:mah] synonym: "activation of neutrophil mediated cytotoxicity" NARROW [GOC:mah] synonym: "positive regulation of neutrophil mediated cell killing" EXACT [GOC:add] synonym: "stimulation of neutrophil mediated cytotoxicity" NARROW [GOC:mah] synonym: "up regulation of neutrophil mediated cytotoxicity" EXACT [GOC:mah] synonym: "up-regulation of neutrophil mediated cytotoxicity" EXACT [GOC:mah] synonym: "upregulation of neutrophil mediated cytotoxicity" EXACT [GOC:mah] is_a: GO:0001912 ! positive regulation of leukocyte mediated cytotoxicity is_a: GO:0002888 ! positive regulation of myeloid leukocyte mediated immunity is_a: GO:0070948 ! regulation of neutrophil mediated cytotoxicity intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0070942 ! positively regulates neutrophil mediated cytotoxicity relationship: RO:0002213 GO:0070942 ! positively regulates neutrophil mediated cytotoxicity creation_date: 2009-10-01T02:28:49Z [Term] id: GO:0070977 name: bone maturation namespace: biological_process def: "A developmental process, independent of morphogenetic (shape) change, that is required for bone to attain its fully functional state." [GOC:dph, GOC:mah] is_a: GO:0048799 ! animal organ maturation intersection_of: GO:0021700 ! developmental maturation intersection_of: RO:0002299 UBERON:0001474 ! results in maturation of bone element relationship: BFO:0000050 GO:0060348 ! part of bone development relationship: RO:0002299 UBERON:0001474 ! results in maturation of bone element creation_date: 2009-10-05T04:35:31Z [Term] id: GO:0070978 name: voltage-gated calcium channel complex assembly namespace: biological_process def: "Cellular protein complex assembly that results in the formation of a voltage-gated calcium channel complex." [GOC:mh] is_a: GO:0065003 ! protein-containing complex assembly intersection_of: GO:0022607 ! cellular component assembly intersection_of: RO:0002588 GO:0005891 ! results in assembly of voltage-gated calcium channel complex relationship: RO:0002588 GO:0005891 ! results in assembly of voltage-gated calcium channel complex creation_date: 2009-10-06T04:51:13Z [Term] id: GO:0070998 name: sensory perception of gravity namespace: biological_process def: "The series of events required for an organism to receive a gravitational stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process." [GOC:mah] is_a: GO:0007600 ! sensory perception creation_date: 2009-11-03T03:25:12Z [Term] id: GO:0070999 name: detection of mechanical stimulus involved in sensory perception of gravity namespace: biological_process def: "The series of events involved in the perception of gravity in which a sensory mechanical stimulus is received and converted into a molecular signal." [GOC:dos, GOC:mah] is_a: GO:0009590 ! detection of gravity is_a: GO:0050974 ! detection of mechanical stimulus involved in sensory perception intersection_of: GO:0050982 ! detection of mechanical stimulus intersection_of: BFO:0000050 GO:0070998 ! part of sensory perception of gravity relationship: BFO:0000050 GO:0070998 ! part of sensory perception of gravity creation_date: 2009-11-03T03:27:30Z [Term] id: GO:0071166 name: ribonucleoprotein complex localization namespace: biological_process def: "Any process in which a ribonucleoprotein complex is transported to, or maintained in, a specific location within a cell." [GOC:mah] synonym: "cellular ribonucleoprotein complex localization" EXACT [GOC:mah] synonym: "establishment and maintenance of ribonucleoprotein complex localization" EXACT [GOC:mah] synonym: "ribonucleoprotein complex localisation" EXACT [GOC:mah] synonym: "RNP localization" EXACT [GOC:mah] is_a: GO:0051641 ! cellular localization creation_date: 2009-11-19T04:46:05Z [Term] id: GO:0071168 name: protein localization to chromatin namespace: biological_process def: "Any process in which a protein is transported to, or maintained at, a part of a chromosome that is organized into chromatin." [GOC:mah] synonym: "protein localisation to chromatin" EXACT [GOC:mah] is_a: GO:0034502 ! protein localization to chromosome intersection_of: GO:0008104 ! intracellular protein localization intersection_of: RO:0002339 GO:0000785 ! has target end location chromatin relationship: RO:0002339 GO:0000785 ! has target end location chromatin creation_date: 2009-11-20T11:51:20Z [Term] id: GO:0071169 name: establishment of protein localization to chromatin namespace: biological_process def: "The directed movement of a protein to a part of a chromosome that is organized into chromatin." [GOC:mah] synonym: "establishment of protein localisation to chromatin" EXACT [GOC:mah] is_a: GO:0070199 ! establishment of protein localization to chromosome intersection_of: GO:0045184 ! establishment of protein localization intersection_of: RO:0002339 GO:0000785 ! has target end location chromatin relationship: RO:0002339 GO:0000785 ! has target end location chromatin creation_date: 2009-11-20T11:52:43Z [Term] id: GO:0071214 name: cellular response to abiotic stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an abiotic (non-living) stimulus." [GOC:mah] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_annotate synonym: "cellular response to abiotic stress" NARROW [GOC:mah] is_a: GO:0009628 ! response to abiotic stimulus is_a: GO:0104004 ! cellular response to environmental stimulus creation_date: 2009-12-03T01:02:11Z [Term] id: GO:0071229 name: cellular response to acid chemical namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus by the chemical structure of the anion portion of the dissociated acid (rather than the acid acting as a proton donor). The acid chemical may be in gaseous, liquid or solid form." [GOC:go_curators, GOC:mah, Wikipedia:Acid] comment: This term should be used to describe a response to a specific acid as a chemical. E.g., if a cell were responding to glutamate, then the response would be glutamate-specific; the cell is actually responding to the chemical structure of the anion portion of the dissociated acid. Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. If annotating experiments where an acid is playing a role as a proton donor, please annotate to GO:0071468 'cellular response to acidic pH' instead. subset: gocheck_do_not_annotate synonym: "cellular response to acid" BROAD [] synonym: "cellular response to acid anion" RELATED [] synonym: "cellular response to oxoanion" RELATED [] is_a: GO:0001101 ! response to acid chemical is_a: GO:0070887 ! cellular response to chemical stimulus creation_date: 2009-12-03T02:07:23Z [Term] id: GO:0071230 name: cellular response to amino acid stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amino acid stimulus. An amino acid is a carboxylic acids containing one or more amino groups." [GOC:mah] synonym: "cellular response to amino acid" EXACT [GOC:mah] is_a: GO:0043200 ! response to amino acid is_a: GO:0071229 ! cellular response to acid chemical intersection_of: GO:0070887 ! cellular response to chemical stimulus intersection_of: RO:0004009 CHEBI:35238 ! has primary input creation_date: 2009-12-03T02:08:11Z [Term] id: GO:0071242 name: cellular response to ammonium ion namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ammonium stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:23509267] synonym: "cellular response to ammonia" EXACT [] is_a: GO:0060359 ! response to ammonium ion is_a: GO:1901699 ! cellular response to nitrogen compound intersection_of: GO:0070887 ! cellular response to chemical stimulus intersection_of: RO:0004009 CHEBI:28938 ! has primary input creation_date: 2009-12-03T02:39:40Z [Term] id: GO:0071248 name: cellular response to metal ion namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a metal ion stimulus." [GOC:mah] synonym: "cellular response to heavy metal" NARROW [GOC:mah] synonym: "cellular response to metal" EXACT [GOC:mah] is_a: GO:0010038 ! response to metal ion is_a: GO:0070887 ! cellular response to chemical stimulus intersection_of: GO:0070887 ! cellular response to chemical stimulus intersection_of: RO:0004009 CHEBI:25213 ! has primary input creation_date: 2009-12-03T02:46:31Z [Term] id: GO:0071277 name: cellular response to calcium ion namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a calcium ion stimulus." [GOC:mah] synonym: "cellular response to Ca2+ ion" EXACT [GOC:mah] is_a: GO:0051592 ! response to calcium ion is_a: GO:0071248 ! cellular response to metal ion intersection_of: GO:0070887 ! cellular response to chemical stimulus intersection_of: RO:0004009 CHEBI:29108 ! has primary input creation_date: 2009-12-10T03:55:01Z [Term] id: GO:0071281 name: cellular response to iron ion namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an iron ion stimulus." [GOC:mah] synonym: "cellular response to iron" EXACT [GOC:mah] is_a: GO:0010039 ! response to iron ion is_a: GO:0071248 ! cellular response to metal ion intersection_of: GO:0070887 ! cellular response to chemical stimulus intersection_of: RO:0004009 CHEBI:24875 ! has primary input creation_date: 2009-12-10T03:57:22Z [Term] id: GO:0071318 name: cellular response to ATP namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ATP (adenosine 5'-triphosphate) stimulus." [GOC:mah] synonym: "cellular response to adenosine 5'-triphosphate" EXACT [GOC:mah] synonym: "cellular response to adenosine triphosphate" EXACT [GOC:mah] is_a: GO:0033198 ! response to ATP is_a: GO:1901699 ! cellular response to nitrogen compound is_a: GO:1901701 ! cellular response to oxygen-containing compound intersection_of: GO:0070887 ! cellular response to chemical stimulus intersection_of: RO:0004009 CHEBI:30616 ! has primary input creation_date: 2009-12-10T05:09:47Z [Term] id: GO:0071322 name: cellular response to carbohydrate stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a carbohydrate stimulus." [GOC:mah] is_a: GO:0009743 ! response to carbohydrate is_a: GO:1901701 ! cellular response to oxygen-containing compound intersection_of: GO:0070887 ! cellular response to chemical stimulus intersection_of: RO:0004009 CHEBI:16646 ! has primary input creation_date: 2009-12-10T05:13:33Z [Term] id: GO:0071326 name: cellular response to monosaccharide stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a monosaccharide stimulus." [GOC:mah] is_a: GO:0034284 ! response to monosaccharide is_a: GO:0071322 ! cellular response to carbohydrate stimulus intersection_of: GO:0070887 ! cellular response to chemical stimulus intersection_of: RO:0004009 CHEBI:35381 ! has primary input creation_date: 2009-12-10T05:27:18Z [Term] id: GO:0071331 name: cellular response to hexose stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hexose stimulus." [GOC:mah] is_a: GO:0009746 ! response to hexose is_a: GO:0071326 ! cellular response to monosaccharide stimulus intersection_of: GO:0070887 ! cellular response to chemical stimulus intersection_of: RO:0004009 CHEBI:18133 ! has primary input creation_date: 2009-12-10T05:37:00Z [Term] id: GO:0071333 name: cellular response to glucose stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucose stimulus." [GOC:mah] is_a: GO:0001678 ! intracellular glucose homeostasis is_a: GO:0009749 ! response to glucose is_a: GO:0071331 ! cellular response to hexose stimulus intersection_of: GO:0070887 ! cellular response to chemical stimulus intersection_of: RO:0004009 CHEBI:4167 ! has primary input creation_date: 2009-12-10T05:38:03Z [Term] id: GO:0071345 name: cellular response to cytokine stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cytokine stimulus." [GOC:mah] xref: Reactome:R-HSA-9007892 "Interleukin-38 signaling" xref: Reactome:R-HSA-9008059 "Interleukin-37 signaling" is_a: GO:0034097 ! response to cytokine creation_date: 2009-12-11T02:41:12Z [Term] id: GO:0071375 name: cellular response to peptide hormone stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptide hormone stimulus. A peptide hormone is any of a class of peptides that are secreted into the blood stream and have endocrine functions in living animals." [GOC:mah] synonym: "cellular response to polypeptide hormone stimulus" EXACT [GOC:mah] is_a: GO:0032870 ! cellular response to hormone stimulus is_a: GO:0043434 ! response to peptide hormone is_a: GO:1901699 ! cellular response to nitrogen compound is_a: GO:1901701 ! cellular response to oxygen-containing compound intersection_of: GO:0070887 ! cellular response to chemical stimulus intersection_of: RO:0004009 CHEBI:25905 ! has primary input property_value: RO:0002161 NCBITaxon:4751 creation_date: 2009-12-11T03:24:18Z [Term] id: GO:0071377 name: cellular response to glucagon stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucagon stimulus." [GOC:mah] xref: Reactome:R-HSA-163359 "Glucagon signaling in metabolic regulation" is_a: GO:0033762 ! response to glucagon is_a: GO:0071375 ! cellular response to peptide hormone stimulus intersection_of: GO:0070887 ! cellular response to chemical stimulus intersection_of: RO:0004009 CHEBI:5391 ! has primary input property_value: RO:0002161 NCBITaxon:4751 creation_date: 2009-12-11T03:25:07Z [Term] id: GO:0071383 name: cellular response to steroid hormone stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a steroid hormone stimulus." [GOC:mah] xref: Reactome:R-HSA-3371497 "HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand" is_a: GO:0032870 ! cellular response to hormone stimulus is_a: GO:0048545 ! response to steroid hormone is_a: GO:0071396 ! cellular response to lipid intersection_of: GO:0070887 ! cellular response to chemical stimulus intersection_of: RO:0004009 CHEBI:26764 ! has primary input property_value: RO:0002161 NCBITaxon:4751 creation_date: 2009-12-11T03:49:02Z [Term] id: GO:0071384 name: cellular response to corticosteroid stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a corticosteroid hormone stimulus. A corticosteroid is a steroid hormone that is produced in the adrenal cortex. Corticosteroids are involved in a wide range of physiologic systems such as stress response, immune response and regulation of inflammation, carbohydrate metabolism, protein catabolism, blood electrolyte levels, and behavior. They include glucocorticoids and mineralocorticoids." [GOC:mah] is_a: GO:0031960 ! response to corticosteroid is_a: GO:0071383 ! cellular response to steroid hormone stimulus intersection_of: GO:0070887 ! cellular response to chemical stimulus intersection_of: RO:0004009 CHEBI:36699 ! has primary input relationship: RO:0004009 CHEBI:36699 ! has primary input property_value: RO:0002161 NCBITaxon:4751 creation_date: 2009-12-11T03:52:07Z [Term] id: GO:0071385 name: cellular response to glucocorticoid stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucocorticoid stimulus. Glucocorticoids are hormonal C21 corticosteroids synthesized from cholesterol with the ability to bind with the cortisol receptor and trigger similar effects. Glucocorticoids act primarily on carbohydrate and protein metabolism, and have anti-inflammatory effects." [GOC:mah] is_a: GO:0051384 ! response to glucocorticoid is_a: GO:0071384 ! cellular response to corticosteroid stimulus intersection_of: GO:0070887 ! cellular response to chemical stimulus intersection_of: RO:0004009 CHEBI:24261 ! has primary input property_value: RO:0002161 NCBITaxon:4751 creation_date: 2009-12-11T03:53:56Z [Term] id: GO:0071389 name: cellular response to mineralocorticoid stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mineralocorticoid stimulus. Mineralocorticoids are hormonal C21 corticosteroids synthesized from cholesterol and characterized by their similarity to aldosterone. Mineralocorticoids act primarily on water and electrolyte balance." [GOC:mah] is_a: GO:0051385 ! response to mineralocorticoid is_a: GO:0071384 ! cellular response to corticosteroid stimulus intersection_of: GO:0070887 ! cellular response to chemical stimulus intersection_of: RO:0004009 CHEBI:25354 ! has primary input property_value: RO:0002161 NCBITaxon:4751 creation_date: 2009-12-11T03:59:02Z [Term] id: GO:0071392 name: cellular response to estradiol stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of stimulus by estradiol, a C18 steroid hormone hydroxylated at C3 and C17 that acts as a potent estrogen." [GOC:mah] synonym: "cellular response to E2 stimulus" EXACT [GOC:mah] is_a: GO:0032355 ! response to estradiol is_a: GO:0071396 ! cellular response to lipid is_a: GO:1901701 ! cellular response to oxygen-containing compound intersection_of: GO:0070887 ! cellular response to chemical stimulus intersection_of: RO:0004009 CHEBI:23965 ! has primary input creation_date: 2009-12-11T04:10:31Z [Term] id: GO:0071393 name: cellular response to progesterone stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a progesterone stimulus." [GOC:mah] is_a: GO:0032570 ! response to progesterone is_a: GO:0071383 ! cellular response to steroid hormone stimulus is_a: GO:1901655 ! cellular response to ketone intersection_of: GO:0070887 ! cellular response to chemical stimulus intersection_of: RO:0004009 CHEBI:17026 ! has primary input property_value: RO:0002161 NCBITaxon:4751 creation_date: 2009-12-11T04:11:13Z [Term] id: GO:0071394 name: cellular response to testosterone stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a testosterone stimulus." [GOC:mah] is_a: GO:0033574 ! response to testosterone is_a: GO:0071396 ! cellular response to lipid is_a: GO:1901655 ! cellular response to ketone intersection_of: GO:0070887 ! cellular response to chemical stimulus intersection_of: RO:0004009 CHEBI:17347 ! has primary input creation_date: 2009-12-11T04:11:29Z [Term] id: GO:0071396 name: cellular response to lipid namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipid stimulus." [GOC:mah] is_a: GO:0033993 ! response to lipid is_a: GO:0070887 ! cellular response to chemical stimulus intersection_of: GO:0070887 ! cellular response to chemical stimulus intersection_of: RO:0004009 CHEBI:18059 ! has primary input creation_date: 2009-12-11T04:37:10Z [Term] id: GO:0071398 name: cellular response to fatty acid namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a fatty acid stimulus." [GOC:mah] is_a: GO:0070542 ! response to fatty acid is_a: GO:0071396 ! cellular response to lipid is_a: GO:1901701 ! cellular response to oxygen-containing compound intersection_of: GO:0070887 ! cellular response to chemical stimulus intersection_of: RO:0004009 CHEBI:28868 ! has primary input creation_date: 2009-12-11T04:39:56Z [Term] id: GO:0071402 name: cellular response to lipoprotein particle stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipoprotein particle stimulus." [GOC:mah] is_a: BFO:0000003 is_a: GO:0051716 ! cellular response to stimulus intersection_of: GO:0051716 ! cellular response to stimulus intersection_of: RO:0004009 GO:1990777 ! has primary input lipoprotein particle relationship: RO:0004009 GO:1990777 ! has primary input lipoprotein particle creation_date: 2009-12-14T02:48:51Z [Term] id: GO:0071418 name: cellular response to amine stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amine stimulus. An amine is a compound formally derived from ammonia by replacing one, two or three hydrogen atoms by hydrocarbyl groups." [GOC:mah] is_a: GO:0014075 ! response to amine is_a: GO:1901699 ! cellular response to nitrogen compound intersection_of: GO:0070887 ! cellular response to chemical stimulus intersection_of: RO:0004009 CHEBI:32952 ! has primary input creation_date: 2009-12-14T04:08:17Z [Term] id: GO:0071420 name: cellular response to histamine namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a histamine stimulus. Histamine, the biogenic amine 2-(1H-imidazol-4-yl)ethanamine, is involved in local immune responses as well as regulating physiological function in the gut and acting as a neurotransmitter." [GOC:mah] synonym: "cellular response to histamine stimulus" EXACT [GOC:mah] is_a: GO:0034776 ! response to histamine is_a: GO:1901699 ! cellular response to nitrogen compound intersection_of: GO:0070887 ! cellular response to chemical stimulus intersection_of: RO:0004009 CHEBI:58432 ! has primary input creation_date: 2009-12-14T04:09:25Z [Term] id: GO:0071425 name: hematopoietic stem cell proliferation namespace: biological_process def: "The expansion of a hematopoietic stem cell population by cell division. A hematopoietic stem cell is a stem cell from which all cells of the lymphoid and myeloid lineages develop." [CL:0000037, GOC:add, GOC:BHF, GOC:mah, GOC:rl] synonym: "hemopoietic stem cell proliferation" EXACT [] is_a: GO:0072089 ! stem cell proliferation intersection_of: GO:0008283 ! cell population proliferation intersection_of: RO:0012003 CL:0000037 ! acts on population of hematopoietic stem cell relationship: BFO:0000050 GO:0030097 ! part of hemopoiesis relationship: RO:0012003 CL:0000037 ! acts on population of hematopoietic stem cell creation_date: 2009-12-16T10:22:52Z [Term] id: GO:0071450 name: cellular response to oxygen radical namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an oxygen radical stimulus. An oxygen radical is any oxygen species that carries a free electron; examples include hydroxyl radicals and the superoxide anion." [GOC:mah] is_a: GO:0000305 ! response to oxygen radical is_a: GO:0034614 ! cellular response to reactive oxygen species intersection_of: GO:0070887 ! cellular response to chemical stimulus intersection_of: RO:0004009 CHEBI:61073 ! has primary input creation_date: 2009-12-16T04:38:52Z [Term] id: GO:0071451 name: cellular response to superoxide namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a superoxide stimulus. Superoxide is the anion, oxygen-, formed by addition of one electron to dioxygen (O2) or any compound containing the superoxide anion." [GOC:mah] is_a: GO:0000303 ! response to superoxide is_a: GO:0071450 ! cellular response to oxygen radical intersection_of: GO:0070887 ! cellular response to chemical stimulus intersection_of: RO:0004009 CHEBI:18421 ! has primary input creation_date: 2009-12-16T04:39:14Z [Term] id: GO:0071462 name: cellular response to water stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of water." [GOC:mah] is_a: GO:0009415 ! response to water is_a: GO:0071214 ! cellular response to abiotic stimulus is_a: GO:0071229 ! cellular response to acid chemical is_a: GO:1901701 ! cellular response to oxygen-containing compound intersection_of: GO:0070887 ! cellular response to chemical stimulus intersection_of: RO:0004009 CHEBI:15377 ! has primary input creation_date: 2009-12-18T11:32:44Z [Term] id: GO:0071495 name: cellular response to endogenous stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus arising within the organism." [GOC:mah] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_annotate xref: Reactome:R-HSA-9860931 "Response of endothelial cells to shear stress" is_a: GO:0009719 ! response to endogenous stimulus creation_date: 2009-12-18T02:25:40Z [Term] id: GO:0071542 name: dopaminergic neuron differentiation namespace: biological_process def: "The process in which a neuroblast acquires the specialized structural and functional features of a dopaminergic neuron, a neuron that secretes dopamine." [GOC:rph] is_a: GO:0030182 ! neuron differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000700 ! results in acquisition of features of dopaminergic neuron relationship: RO:0002315 CL:0000700 ! results in acquisition of features of dopaminergic neuron creation_date: 2010-01-12T02:28:44Z [Term] id: GO:0071599 name: otic vesicle development namespace: biological_process def: "The process whose specific outcome is the progression of the otic vesicle over time, from its formation to the mature structure. The otic vesicle is a transient embryonic structure formed during development of the vertebrate inner ear." [GOC:mah] is_a: GO:0007423 ! sensory organ development is_a: GO:0035295 ! tube development is_a: GO:0048839 ! inner ear development is_a: GO:0060429 ! epithelium development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0003051 ! results in development of ear vesicle relationship: RO:0002296 UBERON:0003051 ! results in development of ear vesicle creation_date: 2010-02-04T04:07:17Z [Term] id: GO:0071600 name: otic vesicle morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the otic vesicle are generated and organized. The otic vesicle is a transient embryonic structure formed during development of the vertebrate inner ear." [GOC:mah] is_a: GO:0042472 ! inner ear morphogenesis is_a: GO:0048562 ! embryonic organ morphogenesis is_a: GO:0060562 ! epithelial tube morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0003051 ! results in morphogenesis of ear vesicle relationship: BFO:0000050 GO:0071599 ! part of otic vesicle development relationship: RO:0002298 UBERON:0003051 ! results in morphogenesis of ear vesicle creation_date: 2010-02-04T04:07:27Z [Term] id: GO:0071621 name: granulocyte chemotaxis namespace: biological_process def: "The movement of a granulocyte in response to an external stimulus." [GOC:rph] is_a: GO:0030595 ! leukocyte chemotaxis is_a: GO:0097530 ! granulocyte migration intersection_of: GO:0006935 ! chemotaxis intersection_of: RO:0002565 CL:0000094 ! results in movement of granulocyte creation_date: 2010-02-09T04:08:17Z [Term] id: GO:0071622 name: regulation of granulocyte chemotaxis namespace: biological_process def: "Any process that modulates the rate, frequency or extent of granulocyte chemotaxis. Granulocyte chemotaxis is the movement of a granulocyte in response to an external stimulus." [GOC:mah] is_a: GO:0002688 ! regulation of leukocyte chemotaxis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0071621 ! regulates granulocyte chemotaxis relationship: RO:0002211 GO:0071621 ! regulates granulocyte chemotaxis creation_date: 2010-02-09T04:09:24Z [Term] id: GO:0071623 name: negative regulation of granulocyte chemotaxis namespace: biological_process def: "Any process that decreases the rate, frequency or extent of granulocyte chemotaxis. Granulocyte chemotaxis is the movement of a granulocyte in response to an external stimulus." [GOC:mah] is_a: GO:0002689 ! negative regulation of leukocyte chemotaxis is_a: GO:0071622 ! regulation of granulocyte chemotaxis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0071621 ! negatively regulates granulocyte chemotaxis relationship: RO:0002212 GO:0071621 ! negatively regulates granulocyte chemotaxis creation_date: 2010-02-09T04:13:19Z [Term] id: GO:0071624 name: positive regulation of granulocyte chemotaxis namespace: biological_process def: "Any process that increases the rate, frequency or extent of granulocyte chemotaxis. Granulocyte chemotaxis is the movement of a granulocyte in response to an external stimulus." [GOC:mah] is_a: GO:0002690 ! positive regulation of leukocyte chemotaxis is_a: GO:0071622 ! regulation of granulocyte chemotaxis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0071621 ! positively regulates granulocyte chemotaxis relationship: RO:0002213 GO:0071621 ! positively regulates granulocyte chemotaxis creation_date: 2010-02-09T04:15:36Z [Term] id: GO:0071626 name: mastication namespace: biological_process def: "The process of biting and mashing food with the teeth prior to swallowing." [GOC:gvg] synonym: "chewing" EXACT [GOC:mah] is_a: GO:0022600 ! digestive system process property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 creation_date: 2010-02-10T11:19:48Z [Term] id: GO:0071670 name: smooth muscle cell chemotaxis namespace: biological_process def: "The directed movement of a smooth muscle cell in response to an external stimulus." [GOC:mah] is_a: GO:0014909 ! smooth muscle cell migration is_a: GO:0060326 ! cell chemotaxis intersection_of: GO:0006935 ! chemotaxis intersection_of: RO:0002565 CL:0000192 ! results in movement of smooth muscle cell property_value: RO:0002161 NCBITaxon:451864 creation_date: 2010-02-16T01:32:59Z [Term] id: GO:0071671 name: regulation of smooth muscle cell chemotaxis namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of smooth muscle cell chemotaxis." [GOC:mah] is_a: GO:0014910 ! regulation of smooth muscle cell migration is_a: GO:0050920 ! regulation of chemotaxis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0071670 ! regulates smooth muscle cell chemotaxis relationship: RO:0002211 GO:0071670 ! regulates smooth muscle cell chemotaxis property_value: RO:0002161 NCBITaxon:451864 creation_date: 2010-02-16T01:42:03Z [Term] id: GO:0071672 name: negative regulation of smooth muscle cell chemotaxis namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of smooth muscle cell chemotaxis." [GOC:mah] synonym: "down regulation of smooth muscle cell chemotaxis" EXACT [GOC:mah] synonym: "down-regulation of smooth muscle cell chemotaxis" EXACT [GOC:mah] synonym: "downregulation of smooth muscle cell chemotaxis" EXACT [GOC:mah] synonym: "inhibition of smooth muscle cell chemotaxis" NARROW [GOC:mah] is_a: GO:0014912 ! negative regulation of smooth muscle cell migration is_a: GO:0050922 ! negative regulation of chemotaxis is_a: GO:0071671 ! regulation of smooth muscle cell chemotaxis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0071670 ! negatively regulates smooth muscle cell chemotaxis relationship: RO:0002212 GO:0071670 ! negatively regulates smooth muscle cell chemotaxis property_value: RO:0002161 NCBITaxon:451864 creation_date: 2010-02-16T01:44:28Z [Term] id: GO:0071673 name: positive regulation of smooth muscle cell chemotaxis namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of smooth muscle cell chemotaxis." [GOC:mah] synonym: "activation of smooth muscle cell chemotaxis" NARROW [GOC:mah] synonym: "stimulation of smooth muscle cell chemotaxis" NARROW [GOC:mah] synonym: "up regulation of smooth muscle cell chemotaxis" EXACT [GOC:mah] synonym: "up-regulation of smooth muscle cell chemotaxis" EXACT [GOC:mah] synonym: "upregulation of smooth muscle cell chemotaxis" EXACT [GOC:mah] is_a: GO:0014911 ! positive regulation of smooth muscle cell migration is_a: GO:0050921 ! positive regulation of chemotaxis is_a: GO:0071671 ! regulation of smooth muscle cell chemotaxis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0071670 ! positively regulates smooth muscle cell chemotaxis relationship: RO:0002213 GO:0071670 ! positively regulates smooth muscle cell chemotaxis property_value: RO:0002161 NCBITaxon:451864 creation_date: 2010-02-16T01:48:14Z [Term] id: GO:0071674 name: mononuclear cell migration namespace: biological_process def: "The movement of a mononuclear cell within or between different tissues and organs of the body." [GOC:mah] is_a: GO:0050900 ! leukocyte migration intersection_of: GO:0016477 ! cell migration intersection_of: RO:0002565 CL:0000842 ! results in movement of mononuclear leukocyte relationship: RO:0002565 CL:0000842 ! results in movement of mononuclear leukocyte creation_date: 2010-02-16T02:11:00Z [Term] id: GO:0071675 name: regulation of mononuclear cell migration namespace: biological_process def: "Any process that modulates the rate, frequency or extent of mononuclear cell migration. Mononuclear cell migration is the movement of a mononuclear cell within or between different tissues and organs of the body." [GOC:mah] is_a: GO:0002685 ! regulation of leukocyte migration intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0071674 ! regulates mononuclear cell migration relationship: RO:0002211 GO:0071674 ! regulates mononuclear cell migration creation_date: 2010-02-16T02:11:53Z [Term] id: GO:0071676 name: negative regulation of mononuclear cell migration namespace: biological_process def: "Any process that decreases the rate, frequency or extent of mononuclear cell migration. Mononuclear cell migration is the movement of a mononuclear cell within or between different tissues and organs of the body." [GOC:mah] synonym: "down regulation of mononuclear cell migration" EXACT [GOC:mah] synonym: "down-regulation of mononuclear cell migration" EXACT [GOC:mah] synonym: "downregulation of mononuclear cell migration" EXACT [GOC:mah] synonym: "inhibition of mononuclear cell migration" NARROW [GOC:mah] is_a: GO:0002686 ! negative regulation of leukocyte migration is_a: GO:0071675 ! regulation of mononuclear cell migration intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0071674 ! negatively regulates mononuclear cell migration relationship: RO:0002212 GO:0071674 ! negatively regulates mononuclear cell migration creation_date: 2010-02-16T02:13:55Z [Term] id: GO:0071677 name: positive regulation of mononuclear cell migration namespace: biological_process def: "Any process that increases the rate, frequency or extent of mononuclear cell migration. Mononuclear cell migration is the movement of a mononuclear cell within or between different tissues and organs of the body." [GOC:mah] synonym: "activation of mononuclear cell migration" NARROW [GOC:mah] synonym: "stimulation of mononuclear cell migration" NARROW [GOC:mah] synonym: "up regulation of mononuclear cell migration" EXACT [GOC:mah] synonym: "up-regulation of mononuclear cell migration" EXACT [GOC:mah] synonym: "upregulation of mononuclear cell migration" EXACT [GOC:mah] is_a: GO:0002687 ! positive regulation of leukocyte migration is_a: GO:0071675 ! regulation of mononuclear cell migration intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0071674 ! positively regulates mononuclear cell migration relationship: RO:0002213 GO:0071674 ! positively regulates mononuclear cell migration creation_date: 2010-02-16T02:15:29Z [Term] id: GO:0071692 name: protein localization to extracellular region namespace: biological_process def: "Any process in which a protein is transported from one specific location in the extracellular region to another, or maintained in a specific extracellular location." [GOC:mah] synonym: "protein localisation in extracellular region" EXACT [GOC:mah] synonym: "protein localization in extracellular region" EXACT [] is_a: BFO:0000003 is_a: GO:0033036 ! macromolecule localization intersection_of: GO:0033036 ! macromolecule localization intersection_of: RO:0002339 GO:0005576 ! has target end location extracellular region intersection_of: RO:0004009 PR:000000001 ! has primary input protein relationship: RO:0002339 GO:0005576 ! has target end location extracellular region relationship: RO:0004009 PR:000000001 ! has primary input protein creation_date: 2010-02-25T04:00:13Z [Term] id: GO:0071695 name: anatomical structure maturation namespace: biological_process def: "A developmental process, independent of morphogenetic (shape) change, that is required for an anatomical structure to attain its fully functional state." [GOC:mah] is_a: BFO:0000003 is_a: GO:0021700 ! developmental maturation intersection_of: GO:0021700 ! developmental maturation intersection_of: RO:0002299 UBERON:0000061 ! results in maturation of anatomical structure relationship: BFO:0000050 GO:0048856 ! part of anatomical structure development relationship: RO:0002299 UBERON:0000061 ! results in maturation of anatomical structure creation_date: 2010-03-02T11:43:38Z [Term] id: GO:0071696 name: ectodermal placode development namespace: biological_process def: "The progression of an ectodermal placode over time from its initial formation until its mature state. An ectodermal placode is a thickening of the ectoderm that is the primordium of many structures derived from the ectoderm." [GOC:mah] is_a: GO:0048856 ! anatomical structure development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0005085 ! results in development of ectodermal placode relationship: RO:0002296 UBERON:0005085 ! results in development of ectodermal placode creation_date: 2010-03-02T11:48:01Z [Term] id: GO:0071697 name: ectodermal placode morphogenesis namespace: biological_process def: "The process in which the anatomical structures of an ectodermal placode are generated and organized. An ectodermal placode is a thickening of the ectoderm that is the primordium of many structures derived from the ectoderm." [GOC:mah] is_a: BFO:0000003 is_a: GO:0009653 ! anatomical structure morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0005085 ! results in morphogenesis of ectodermal placode relationship: BFO:0000050 GO:0071696 ! part of ectodermal placode development relationship: RO:0002298 UBERON:0005085 ! results in morphogenesis of ectodermal placode creation_date: 2010-03-02T11:49:51Z [Term] id: GO:0071698 name: olfactory placode development namespace: biological_process def: "The progression of the olfactory placode over time from its initial formation until its mature state. The olfactory placode is a thickening of the neural ectoderm in the head region of the vertebrate embryo which develops into the olfactory region of the nasal cavity." [GOC:mah] is_a: GO:0071696 ! ectodermal placode development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0003050 ! results in development of olfactory placode relationship: RO:0002296 UBERON:0003050 ! results in development of olfactory placode creation_date: 2010-03-02T12:45:14Z [Term] id: GO:0071699 name: olfactory placode morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the olfactory placode are generated and organized. The olfactory placode is a thickening of the neural ectoderm in the head region of the vertebrate embryo which develops into the olfactory region of the nasal cavity." [GOC:mah] is_a: GO:0048598 ! embryonic morphogenesis is_a: GO:0071697 ! ectodermal placode morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0003050 ! results in morphogenesis of olfactory placode relationship: BFO:0000050 GO:0071698 ! part of olfactory placode development relationship: RO:0002298 UBERON:0003050 ! results in morphogenesis of olfactory placode creation_date: 2010-03-02T12:45:45Z [Term] id: GO:0071700 name: olfactory placode maturation namespace: biological_process def: "A developmental process, independent of morphogenetic (shape) change, that is required for the olfactory placode to attain its fully functional state. The olfactory placode is a thickening of the neural ectoderm in the head region of the vertebrate embryo which develops into the olfactory region of the nasal cavity." [GOC:mah] is_a: GO:0071695 ! anatomical structure maturation intersection_of: GO:0021700 ! developmental maturation intersection_of: RO:0002299 UBERON:0003050 ! results in maturation of olfactory placode relationship: BFO:0000050 GO:0071698 ! part of olfactory placode development relationship: RO:0002299 UBERON:0003050 ! results in maturation of olfactory placode creation_date: 2010-03-02T01:10:54Z [Term] id: GO:0071705 name: nitrogen compound transport namespace: biological_process def: "The directed movement of nitrogen-containing compounds into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah] subset: gocheck_obsoletion_candidate is_a: BFO:0000003 is_a: GO:0006810 ! transport intersection_of: GO:0006810 ! transport intersection_of: RO:0004009 CHEBI:51143 ! has primary input relationship: RO:0004009 CHEBI:51143 ! has primary input creation_date: 2010-03-08T03:56:28Z [Term] id: GO:0071706 name: tumor necrosis factor superfamily cytokine production namespace: biological_process def: "The appearance of any member of the TNF superfamily due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:add] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms. subset: gocheck_do_not_annotate synonym: "TNF superfamily production" RELATED [GOC:rv] synonym: "TNFSF cytokine production" EXACT [GOC:add] is_a: GO:0001816 ! cytokine production property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 creation_date: 2010-03-09T02:40:35Z [Term] id: GO:0071707 name: immunoglobulin heavy chain V-D-J recombination namespace: biological_process def: "The process in which immunoglobulin heavy chain V, D, and J gene segments are recombined within a single locus utilizing the conserved heptamer and nonomer recombination signal sequences (RSS)." [GOC:add, ISBN:0781735149] synonym: "immunoglobulin V(D)J joining" BROAD [GOC:add] synonym: "immunoglobulin V(D)J recombination" BROAD [GOC:add] synonym: "immunoglobulin V-D-J joining" EXACT [GOC:add] is_a: GO:0033152 ! immunoglobulin V(D)J recombination property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4751 creation_date: 2010-03-09T04:20:31Z [Term] id: GO:0071708 name: immunoglobulin light chain V-J recombination namespace: biological_process def: "The process in which immunoglobulin light chain V and J gene segments are recombined within a single locus utilizing the conserved heptamer and nonomer recombination signal sequences (RSS)." [GOC:add, ISBN:0781735149] synonym: "immunoglobulin V(D)J joining" BROAD [GOC:add] synonym: "immunoglobulin V(D)J recombination" BROAD [GOC:add] synonym: "immunoglobulin V-J joining" EXACT [GOC:add] is_a: GO:0033152 ! immunoglobulin V(D)J recombination property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4751 creation_date: 2010-03-09T04:22:29Z [Term] id: GO:0071709 name: membrane assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form a membrane." [GOC:mah] is_a: GO:0022607 ! cellular component assembly is_a: GO:0061024 ! membrane organization intersection_of: GO:0022607 ! cellular component assembly intersection_of: RO:0002588 GO:0016020 ! results in assembly of membrane relationship: BFO:0000050 GO:0044091 ! part of membrane biogenesis relationship: RO:0002588 GO:0016020 ! results in assembly of membrane creation_date: 2010-03-10T11:19:17Z [Term] id: GO:0071711 name: basement membrane organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the basement membrane." [GOC:mah] comment: Note that this term has no relationship to 'membrane organization ; GO:0061024' because the basement membrane is not a lipid bilayer. synonym: "basement membrane organisation" EXACT [GOC:mah] is_a: GO:0030198 ! extracellular matrix organization intersection_of: GO:0016043 ! cellular component organization intersection_of: RO:0002592 GO:0005604 ! results in organization of basement membrane relationship: RO:0002592 GO:0005604 ! results in organization of basement membrane creation_date: 2010-03-10T11:57:10Z [Term] id: GO:0071731 name: response to nitric oxide namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitric oxide stimulus." [GOC:mah, GOC:yaf] is_a: GO:1901698 ! response to nitrogen compound is_a: GO:1901700 ! response to oxygen-containing compound intersection_of: GO:0050896 ! response to stimulus intersection_of: RO:0004009 CHEBI:16480 ! has primary input relationship: RO:0004009 CHEBI:16480 ! has primary input creation_date: 2010-03-17T04:03:38Z [Term] id: GO:0071732 name: cellular response to nitric oxide namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitric oxide stimulus." [GOC:mah, GOC:yaf] is_a: GO:0071731 ! response to nitric oxide is_a: GO:1901701 ! cellular response to oxygen-containing compound is_a: GO:1902170 ! cellular response to reactive nitrogen species intersection_of: GO:0070887 ! cellular response to chemical stimulus intersection_of: RO:0004009 CHEBI:16480 ! has primary input creation_date: 2010-03-17T04:12:52Z [Term] id: GO:0071735 name: IgG immunoglobulin complex namespace: cellular_component def: "A protein complex composed of two identical immunoglobulin heavy chains of an IgG isotype and two identical immunoglobulin light chains, held together by disulfide bonds. An IgG immunoglobulin complex may be embedded in the plasma membrane or present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph." [GOC:add, ISBN:0781765196] comment: Note that an IgG immunoglobulin complex has the function of antigen binding if a suitable antigen is available. Also, IgG isotypes vary by species. synonym: "IgG1" NARROW [GOC:add] synonym: "IgG2" NARROW [GOC:add] synonym: "IgG2a" NARROW [GOC:add] synonym: "IgG2b" NARROW [GOC:add] synonym: "IgG2c" NARROW [GOC:add] synonym: "IgG3" NARROW [GOC:add] synonym: "IgG4" NARROW [GOC:add] is_a: GO:0019814 ! immunoglobulin complex creation_date: 2010-03-24T01:44:53Z [Term] id: GO:0071736 name: IgG immunoglobulin complex, circulating namespace: cellular_component def: "A protein complex composed of two identical immunoglobulin heavy chains of an IgG isotype and two identical immunoglobulin light chains, held together by disulfide bonds, and present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph." [GOC:add, ISBN:0781765196] comment: Note that an IgG immunoglobulin complex has the function of antigen binding if a suitable antigen is available. Also, IgG isotypes vary by species. synonym: "IgG antibody" NARROW [GOC:add] synonym: "IgG1 antibody" NARROW [GOC:add] synonym: "IgG2 antibody" NARROW [GOC:add] synonym: "IgG2a antibody" NARROW [GOC:add] synonym: "IgG2b antibody" NARROW [GOC:add] synonym: "IgG2c antibody" NARROW [GOC:add] synonym: "IgG3 antibody" NARROW [GOC:add] synonym: "IgG4 antibody" NARROW [GOC:add] is_a: GO:0042571 ! immunoglobulin complex, circulating is_a: GO:0071735 ! IgG immunoglobulin complex property_value: RO:0002161 NCBITaxon:4890 creation_date: 2010-03-24T01:44:53Z [Term] id: GO:0071738 name: IgD immunoglobulin complex namespace: cellular_component def: "A protein complex composed of two identical immunoglobulin heavy chains of the IgD isotype and two identical immunoglobulin light chains, held together by disulfide bonds. An IgD immunoglobulin complex may be embedded in the plasma membrane or present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph." [GOC:add, ISBN:0781765196, PMID:11282392] comment: Note that an IgD immunoglobulin complex has the function of antigen binding if a suitable antigen is available. is_a: GO:0019814 ! immunoglobulin complex creation_date: 2010-03-24T01:44:53Z [Term] id: GO:0071739 name: IgD immunoglobulin complex, circulating namespace: cellular_component def: "A protein complex composed of two identical immunoglobulin heavy chains of the IgD isotype and two identical immunoglobulin light chains, held together by disulfide bonds, and present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph." [GOC:add, ISBN:0781765196, PMID:11282392] comment: Note that an IgD immunoglobulin complex has the function of antigen binding if a suitable antigen is available. synonym: "IgD antibody" EXACT [GOC:add] is_a: GO:0042571 ! immunoglobulin complex, circulating is_a: GO:0071738 ! IgD immunoglobulin complex property_value: RO:0002161 NCBITaxon:4890 creation_date: 2010-03-24T01:44:53Z [Term] id: GO:0071742 name: IgE immunoglobulin complex namespace: cellular_component def: "A protein complex composed of two identical immunoglobulin heavy chains of the IgE isotype and two identical immunoglobulin light chains, held together by disulfide bonds. An IgE immunoglobulin complex may be embedded in the plasma membrane or present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph." [GOC:add, ISBN:0781765196] comment: Note that an IgE immunoglobulin complex has the function of antigen binding if a suitable antigen is available. is_a: GO:0019814 ! immunoglobulin complex creation_date: 2010-03-24T01:44:53Z [Term] id: GO:0071743 name: IgE immunoglobulin complex, circulating namespace: cellular_component def: "A protein complex composed of two identical immunoglobulin heavy chains of the IgE isotype and two identical immunoglobulin light chains, held together by disulfide bonds, and present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph." [GOC:add, ISBN:0781765196] comment: Note that an IgE immunoglobulin complex has the function of antigen binding if a suitable antigen is available. synonym: "IgE antibody" EXACT [GOC:add] is_a: GO:0042571 ! immunoglobulin complex, circulating is_a: GO:0071742 ! IgE immunoglobulin complex property_value: RO:0002161 NCBITaxon:4890 creation_date: 2010-03-24T01:44:53Z [Term] id: GO:0071745 name: IgA immunoglobulin complex namespace: cellular_component def: "A protein complex composed of two identical immunoglobulin heavy chains of the IgA isotype and two identical immunoglobulin light chains, held together by disulfide bonds, and sometimes complexed with J chain or J chain and secretory component. An IgA immunoglobulin complex may be embedded in the plasma membrane or present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph." [GOC:add, ISBN:0781765196, PMID:16362985] comment: Note that an IgA immunoglobulin complex has the function of antigen binding if a suitable antigen is available. synonym: "IgA1 antibody" NARROW [GOC:add] synonym: "IgA2 antibody" NARROW [GOC:add] is_a: GO:0019814 ! immunoglobulin complex creation_date: 2010-03-24T01:44:53Z [Term] id: GO:0071746 name: IgA immunoglobulin complex, circulating namespace: cellular_component def: "A protein complex composed of two identical immunoglobulin heavy chains of an IgA isotype and two identical immunoglobulin light chains, held together by disulfide bonds, sometimes complexed with J chain or J chain and secretory component, and present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph." [GOC:add, ISBN:0781765196, PMID:16362985] comment: Note that an IgA immunoglobulin complex has the function of antigen binding if a suitable antigen is available. synonym: "IgA antibody" EXACT [GOC:add] synonym: "IgA1 antibody" NARROW [GOC:add] synonym: "IgA2 antibody" NARROW [GOC:add] is_a: GO:0042571 ! immunoglobulin complex, circulating is_a: GO:0071745 ! IgA immunoglobulin complex property_value: RO:0002161 NCBITaxon:4890 creation_date: 2010-03-24T01:44:53Z [Term] id: GO:0071753 name: IgM immunoglobulin complex namespace: cellular_component def: "A protein complex composed of two identical immunoglobulin heavy chains of the IgM isotype and two identical immunoglobulin light chains, held together by disulfide bonds, and in its circulating form complexed with J chain in polymeric forms. An IgM immunoglobulin complex may be embedded in the plasma membrane or present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph." [GOC:add, ISBN:0781765196, PMID:20176268] comment: Note that an IgM immunoglobulin complex has the function of antigen binding if a suitable antigen is available. is_a: GO:0019814 ! immunoglobulin complex creation_date: 2010-03-24T01:44:53Z [Term] id: GO:0071754 name: IgM immunoglobulin complex, circulating namespace: cellular_component def: "A polymer of five or six IgM core units each composed of two identical immunoglobulin heavy chains of the IgM isotype and two identical immunoglobulin light chains, held together by disulfide bonds; the individual IgM core units are held together via disulfide bonds with a single J chain polypeptide acting as a bridge between two of the polymeric units. Circulating IgM is present in the extracellular space, in mucosal areas or other tissues, or in the blood or lymph." [GOC:add, ISBN:0781765196, PMID:20176268] comment: Note that an IgM immunoglobulin complex has the function of antigen binding if a suitable antigen is available. synonym: "IgM antibody" EXACT [GOC:add] is_a: GO:0042571 ! immunoglobulin complex, circulating is_a: GO:0071753 ! IgM immunoglobulin complex property_value: RO:0002161 NCBITaxon:4890 creation_date: 2010-03-24T01:44:53Z [Term] id: GO:0071763 name: nuclear membrane organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nuclear inner or outer membrane." [GOC:mah] synonym: "nuclear membrane organisation" EXACT [GOC:mah] synonym: "nuclear membrane organization and biogenesis" RELATED [GOC:mah] is_a: GO:0061024 ! membrane organization intersection_of: GO:0016043 ! cellular component organization intersection_of: RO:0002592 GO:0031965 ! results in organization of nuclear membrane relationship: BFO:0000050 GO:0006998 ! part of nuclear envelope organization relationship: RO:0002592 GO:0031965 ! results in organization of nuclear membrane creation_date: 2010-03-29T03:59:35Z [Term] id: GO:0071764 name: nuclear outer membrane organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nuclear outer membrane." [GOC:mah] synonym: "nuclear outer membrane organisation" EXACT [GOC:mah] synonym: "nuclear outer membrane organization and biogenesis" RELATED [GOC:mah] is_a: GO:0071763 ! nuclear membrane organization intersection_of: GO:0016043 ! cellular component organization intersection_of: RO:0002592 GO:0005640 ! results in organization of nuclear outer membrane relationship: RO:0002592 GO:0005640 ! results in organization of nuclear outer membrane creation_date: 2010-03-29T04:03:37Z [Term] id: GO:0071805 name: potassium ion transmembrane transport namespace: biological_process def: "A process in which a potassium ion is transported from one side of a membrane to the other." [GOC:mah] comment: Note that this term is not intended for use in annotating lateral movement within membranes. synonym: "high affinity potassium ion import" NARROW [] synonym: "high affinity potassium ion uptake" NARROW [GOC:dph, GOC:tb] synonym: "high-affinity potassium ion import" NARROW [] synonym: "high-affinity potassium ion uptake" NARROW [GOC:dph, GOC:tb] synonym: "potassium ion membrane transport" EXACT [] xref: Reactome:R-HSA-1296071 "Potassium Channels" is_a: GO:0006813 ! potassium ion transport is_a: GO:0098655 ! monoatomic cation transmembrane transport intersection_of: GO:0055085 ! transmembrane transport intersection_of: RO:0004009 CHEBI:29103 ! has primary input creation_date: 2010-09-03T02:43:49Z [Term] id: GO:0071806 name: protein transmembrane transport namespace: biological_process def: "The process in which a protein is transported across a membrane." [GOC:mah, GOC:vw] comment: Note that this term is not intended for use in annotating lateral movement within membranes. synonym: "protein membrane transport" EXACT [] is_a: GO:0015031 ! protein transport is_a: GO:0055085 ! transmembrane transport intersection_of: GO:0055085 ! transmembrane transport intersection_of: RO:0004009 CHEBI:36080 ! has primary input creation_date: 2010-09-03T02:54:26Z [Term] id: GO:0071813 name: lipoprotein particle binding namespace: molecular_function def: "Binding to a lipoprotein particle. A lipoprotein particle, also known as a lipoprotein, is a clathrate complex consisting of a lipid enwrapped in a protein host without covalent binding in such a way that the complex has a hydrophilic outer surface consisting of all the protein and the polar ends of any phospholipids." [GOC:BHF, GOC:mah] synonym: "lipoprotein binding" RELATED [GOC:mah] synonym: "plasma lipoprotein binding" RELATED [GOC:mah] synonym: "plasma lipoprotein particle binding" EXACT [GOC:mah] is_a: GO:0071814 ! protein-lipid complex binding intersection_of: GO:0005488 ! binding intersection_of: RO:0004009 GO:1990777 ! has primary input lipoprotein particle relationship: RO:0004009 GO:1990777 ! has primary input lipoprotein particle creation_date: 2010-09-06T03:16:01Z [Term] id: GO:0071814 name: protein-lipid complex binding namespace: molecular_function def: "Binding to a protein-lipid complex, any macromolecular complex that contains both protein and lipid molecules." [GOC:BHF, GOC:mah] is_a: GO:0044877 ! protein-containing complex binding intersection_of: GO:0005488 ! binding intersection_of: RO:0004009 GO:0032994 ! has primary input protein-lipid complex relationship: RO:0004009 GO:0032994 ! has primary input protein-lipid complex creation_date: 2010-09-06T04:26:27Z [Term] id: GO:0071825 name: protein-lipid complex organization namespace: biological_process def: "Any process in which macromolecules aggregate, disaggregate, or are modified, resulting in the formation, disassembly, or alteration of a protein-lipid complex." [GOC:mah] synonym: "protein-lipid complex subunit organisation" EXACT [GOC:mah] synonym: "protein-lipid complex subunit organization" EXACT [] is_a: GO:0043933 ! protein-containing complex organization intersection_of: GO:0016043 ! cellular component organization intersection_of: RO:0002592 GO:0032994 ! results in organization of protein-lipid complex relationship: RO:0002592 GO:0032994 ! results in organization of protein-lipid complex property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/25143" xsd:anyURI creation_date: 2010-09-08T10:04:36Z [Term] id: GO:0071826 name: protein-RNA complex organization namespace: biological_process def: "Any process in which macromolecules aggregate, disaggregate, or are modified, resulting in the formation, disassembly, or alteration of a ribonucleoprotein complex." [GOC:mah] synonym: "protein-RNA complex subunit organization" EXACT [GOC:mah] synonym: "ribonucleoprotein complex subunit organisation" EXACT [GOC:mah] synonym: "ribonucleoprotein complex subunit organization" EXACT [] synonym: "RNA-protein complex subunit organization" EXACT [GOC:mah] is_a: GO:0043933 ! protein-containing complex organization intersection_of: GO:0016043 ! cellular component organization intersection_of: RO:0002592 GO:1990904 ! results in organization of ribonucleoprotein complex relationship: RO:0002592 GO:1990904 ! results in organization of ribonucleoprotein complex property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/25143" xsd:anyURI creation_date: 2010-09-08T10:10:35Z [Term] id: GO:0071840 name: cellular component organization or biogenesis namespace: biological_process def: "A process that results in the biosynthesis of constituent macromolecules, assembly, arrangement of constituent parts, or disassembly of a cellular component." [GOC:mah] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_annotate subset: goslim_flybase_ribbon subset: goslim_metagenomics synonym: "cellular component organisation or biogenesis" EXACT [GOC:mah] synonym: "cellular component organisation or biogenesis at cellular level" EXACT [GOC:mah] synonym: "cellular component organization or biogenesis at cellular level" EXACT [] is_a: GO:0009987 ! cellular process property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/27189" xsd:anyURI creation_date: 2010-09-10T01:39:16Z [Term] id: GO:0071867 name: response to monoamine namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a monoamine stimulus. A monoamine is any of a group of molecular messengers that contain one amino group that is connected to an aromatic ring by ethylene group (-CH2-CH2-). Monoamines are derived from the aromatic amino acids phenylalanine, tyrosine, histidine and tryptophan." [GOC:mah] synonym: "response to monoamine stimulus" EXACT [GOC:dos] is_a: GO:1901698 ! response to nitrogen compound intersection_of: GO:0050896 ! response to stimulus intersection_of: RO:0004009 CHEBI:63534 ! has primary input relationship: RO:0004009 CHEBI:63534 ! has primary input creation_date: 2010-09-13T02:36:37Z [Term] id: GO:0071868 name: cellular response to monoamine stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a monoamine stimulus. A monoamine is any of a group of molecular messengers that contain one amino group that is connected to an aromatic ring by ethylene group (-CH2-CH2-). Monoamines are derived from the aromatic amino acids phenylalanine, tyrosine, histidine and tryptophan." [GOC:mah] is_a: GO:0071867 ! response to monoamine is_a: GO:1901699 ! cellular response to nitrogen compound intersection_of: GO:0070887 ! cellular response to chemical stimulus intersection_of: RO:0004009 CHEBI:63534 ! has primary input creation_date: 2010-09-13T02:38:52Z [Term] id: GO:0071869 name: response to catecholamine namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a catecholamine stimulus. A catecholamine is any of a group of biogenic amines that includes 4-(2-aminoethyl)pyrocatechol [4-(2-aminoethyl)benzene-1,2-diol] and derivatives formed by substitution." [GOC:BHF, GOC:mah] synonym: "response to catecholamine stimulus" EXACT [GOC:dos] is_a: GO:0071867 ! response to monoamine is_a: GO:1901700 ! response to oxygen-containing compound intersection_of: GO:0050896 ! response to stimulus intersection_of: RO:0004009 CHEBI:33567 ! has primary input relationship: RO:0004009 CHEBI:33567 ! has primary input creation_date: 2010-09-13T02:51:13Z [Term] id: GO:0071870 name: cellular response to catecholamine stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a catecholamine stimulus. A catecholamine is any of a group of biogenic amines that includes 4-(2-aminoethyl)pyrocatechol [4-(2-aminoethyl)benzene-1,2-diol] and derivatives formed by substitution." [GOC:BHF, GOC:mah] is_a: GO:0071868 ! cellular response to monoamine stimulus is_a: GO:0071869 ! response to catecholamine is_a: GO:1901701 ! cellular response to oxygen-containing compound intersection_of: GO:0070887 ! cellular response to chemical stimulus intersection_of: RO:0004009 CHEBI:33567 ! has primary input creation_date: 2010-09-13T02:54:50Z [Term] id: GO:0071873 name: response to norepinephrine namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a norepinephrine stimulus. Norepinephrine is a catecholamine that has the formula C8H11NO3; it acts as a hormone, and as a neurotransmitter in most of the sympathetic nervous system." [GOC:BHF, GOC:mah] comment: Note that epinephrine and norepinephrine are ligands for the same receptors, and there are multiple adrenergic receptors. synonym: "response to noradrenaline stimulus" EXACT [GOC:mah] synonym: "response to norepinephrine stimulus" EXACT [GOC:dos] is_a: GO:0071869 ! response to catecholamine intersection_of: GO:0050896 ! response to stimulus intersection_of: RO:0004009 CHEBI:72587 ! has primary input relationship: RO:0004009 CHEBI:72587 ! has primary input creation_date: 2010-09-13T03:31:53Z [Term] id: GO:0071874 name: cellular response to norepinephrine stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a norepinephrine stimulus. Norepinephrine is a catecholamine that has the formula C8H11NO3; it acts as a hormone, and as a neurotransmitter in most of the sympathetic nervous system." [GOC:BHF, GOC:mah] comment: Note that epinephrine and norepinephrine are ligands for the same receptors, and there are multiple adrenergic receptors. synonym: "cellular response to noradrenaline stimulus" EXACT [GOC:mah] is_a: GO:0071870 ! cellular response to catecholamine stimulus is_a: GO:0071873 ! response to norepinephrine intersection_of: GO:0070887 ! cellular response to chemical stimulus intersection_of: RO:0004009 CHEBI:72587 ! has primary input creation_date: 2010-09-13T03:33:32Z [Term] id: GO:0071887 name: leukocyte apoptotic process namespace: biological_process def: "Any apoptotic process in a leukocyte, an achromatic cell of the myeloid or lymphoid lineages capable of ameboid movement, found in blood or other tissue." [CL:0000738, GOC:BHF, GOC:mah, GOC:mtg_apoptosis] comment: Note that a lymphocyte is a cell of the B cell, T cell, or natural killer cell lineage (CL:0000542). synonym: "leukocyte apoptosis" NARROW [] is_a: GO:0006915 ! apoptotic process intersection_of: GO:0006915 ! apoptotic process intersection_of: BFO:0000066 CL:0000738 ! occurs in leukocyte relationship: BFO:0000066 CL:0000738 ! occurs in leukocyte relationship: RO:0002162 NCBITaxon:7742 ! in taxon Vertebrata creation_date: 2010-09-14T12:44:09Z [Term] id: GO:0071888 name: macrophage apoptotic process namespace: biological_process def: "Any apoptotic process in a macrophage, a mononuclear phagocyte present in a variety of tissues." [CL:0000235, GOC:BHF, GOC:mah, GOC:mtg_apoptosis] comment: Note that a lymphocyte is a cell of the B cell, T cell, or natural killer cell lineage (CL:0000542). synonym: "activation-induced cell death" RELATED [GOC:yaf] synonym: "AICD" RELATED [GOC:yaf] synonym: "macrophage apoptosis" NARROW [] is_a: GO:0006925 ! inflammatory cell apoptotic process is_a: GO:0033028 ! myeloid cell apoptotic process is_a: GO:0071887 ! leukocyte apoptotic process intersection_of: GO:0006915 ! apoptotic process intersection_of: BFO:0000066 CL:0000235 ! occurs in macrophage relationship: BFO:0000066 CL:0000235 ! occurs in macrophage creation_date: 2010-09-14T12:50:40Z [Term] id: GO:0071890 name: bicarbonate binding namespace: molecular_function def: "Binding to bicarbonate ions (CHO3-)." [GOC:curators] synonym: "CHO3- ion binding binding" EXACT [] synonym: "hydrogencarbonate binding" EXACT [CHEBI:17544] is_a: GO:0043168 ! anion binding intersection_of: GO:0005488 ! binding intersection_of: RO:0004009 CHEBI:17544 ! has primary input relationship: RO:0004009 CHEBI:17544 ! has primary input creation_date: 2010-09-14T01:47:43Z [Term] id: GO:0071895 name: odontoblast differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell of neural crest origin acquires the specialized features of an odontoblast, a cell on the outer surface of the dental pulp whose biological function is the creation of dentin." [GOC:sl, PMID:20425127] is_a: GO:0060563 ! neuroepithelial cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000060 ! results in acquisition of features of odontoblast relationship: RO:0002315 CL:0000060 ! results in acquisition of features of odontoblast creation_date: 2010-09-14T04:00:40Z [Term] id: GO:0071897 name: DNA biosynthetic process namespace: biological_process def: "The biosynthetic process resulting in the formation of DNA." [GOC:mah] synonym: "DNA anabolism" EXACT [GOC:mah] synonym: "DNA biosynthesis" EXACT [GOC:mah] synonym: "DNA formation" EXACT [GOC:mah] synonym: "DNA synthesis" EXACT [GOC:mah] is_a: GO:0006259 ! DNA metabolic process is_a: GO:0141187 ! nucleic acid biosynthetic process intersection_of: GO:0009058 ! biosynthetic process intersection_of: RO:0004008 CHEBI:16991 ! has primary output relationship: RO:0004008 CHEBI:16991 ! has primary output creation_date: 2010-09-15T02:14:33Z [Term] id: GO:0071941 name: nitrogen cycle metabolic process namespace: biological_process def: "A nitrogen compound metabolic process that contributes to the nitrogen cycle. The nitrogen cycle is a series of metabolic pathways by which nitrogen is converted between various forms and redox states; it encompasses pathways in which nitrogen is acted upon directly, such as nitrification, denitrification, nitrogen fixation, and mineralization." [GOC:mah, PMID:16675690, Wikipedia:Nitrogen_cycle] subset: goslim_chembl subset: goslim_generic subset: goslim_pombe subset: goslim_prokaryote xref: Wikipedia:Nitrogen_cycle is_a: GO:0008152 ! metabolic process creation_date: 2010-09-30T05:21:03Z [Term] id: GO:0071944 name: cell periphery namespace: cellular_component def: "The broad region around and including the plasma membrane of a cell, encompassing the cell cortex (inside the cell), the plasma membrane, and any external encapsulating structures." [GOC:pdt] subset: goslim_flybase_ribbon is_a: GO:0110165 ! cellular anatomical structure property_value: skos:prefLabel "cell periphery" xsd:string creation_date: 2010-10-04T01:51:47Z [Term] id: GO:0071953 name: elastic fiber namespace: cellular_component def: "An supramolecular fiber that consists of an insoluble core of polymerized tropoelastin monomers and a surrounding mantle of microfibrils. Elastic fibers provide elasticity and recoiling to tissues and organs, and maintain structural integrity against mechanical strain." [GOC:BHF, GOC:mah, PMID:20236620] synonym: "elastic fibre" EXACT [GOC:mah] synonym: "elastin fiber" EXACT [GOC:BHF] is_a: GO:0099512 ! supramolecular fiber relationship: BFO:0000050 GO:0031012 ! part of extracellular matrix property_value: skos:prefLabel "elastic fiber" xsd:string creation_date: 2010-10-11T11:44:57Z [Term] id: GO:0071971 name: extracellular exosome assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form an extracellular vesicular exosome, a membrane-bounded vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Exosomes are defined by their size, which generally ranges from 30 nm to 100 nm." [GOC:mah, GOC:tfm, PMID:19442504, PMID:27462458] synonym: "extracellular vesicular exosome assembly" EXACT [GOC:vesicles] is_a: GO:0016050 ! vesicle organization is_a: GO:0070925 ! organelle assembly intersection_of: GO:0022607 ! cellular component assembly intersection_of: RO:0002588 GO:0070062 ! results in assembly of extracellular exosome relationship: BFO:0000050 GO:0097734 ! part of extracellular exosome biogenesis relationship: RO:0002588 GO:0070062 ! results in assembly of extracellular exosome property_value: RO:0002161 NCBITaxon:4890 creation_date: 2010-10-18T03:44:18Z [Term] id: GO:0072001 name: renal system development namespace: biological_process def: "The process whose specific outcome is the progression of the renal system over time, from its formation to the mature structure. The renal system maintains fluid balance and contributes to electrolyte balance, acid/base balance, and disposal of nitrogenous waste products. In humans, the renal system comprises a pair of kidneys, a pair of ureters, urinary bladder, urethra, sphincter muscle and associated blood vessels." [GOC:mtg_kidney_jan10, GOC:yaf, PMID:6996269] subset: gocheck_do_not_annotate synonym: "urinary system development" BROAD [GOC:yaf] synonym: "urinary tract development" BROAD [GOC:yaf, PMID:17881463] is_a: GO:0048731 ! system development intersection_of: GO:0048731 ! system development intersection_of: RO:0002296 UBERON:0001008 ! results in development of renal system relationship: RO:0002296 UBERON:0001008 ! results in development of renal system creation_date: 2010-01-25T10:31:00Z [Term] id: GO:0072002 name: Malpighian tubule development namespace: biological_process def: "The process whose specific outcome is the progression of the Malpighian tubule over time, from its formation to the mature structure. A Malpighian tubule is a fine, thin-walled excretory tubule in insects which leads into the posterior part of the gut." [FBbt:00005786, GOC:mtg_kidney_jan10, PMID:19783135] is_a: GO:0048513 ! animal organ development is_a: GO:0061326 ! renal tubule development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0001054 ! results in development of Malpighian tubule relationship: RO:0002162 NCBITaxon:50557 ! in taxon Insecta relationship: RO:0002296 UBERON:0001054 ! results in development of Malpighian tubule creation_date: 2010-01-25T10:54:30Z [Term] id: GO:0072003 name: kidney rudiment formation namespace: biological_process def: "The developmental process pertaining to the initial formation of a kidney rudiment from unspecified parts. A kidney is an organ that filters the blood and excretes the end products of body metabolism in the form of urine." [GOC:mtg_kidney_jan10] synonym: "kidney anlage formation" RELATED [GOC:mtg_kidney_jan10] is_a: BFO:0000003 is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0005095 ! results in formation of anatomical entity kidney rudiment relationship: BFO:0000050 GO:0060993 ! part of kidney morphogenesis relationship: RO:0002297 UBERON:0005095 ! results in formation of anatomical entity kidney rudiment creation_date: 2010-01-25T11:18:58Z [Term] id: GO:0072006 name: nephron development namespace: biological_process def: "The process whose specific outcome is the progression of the nephron over time, from its formation to the mature structure. A nephron is the functional unit of the kidney." [GOC:mtg_kidney_jan10] synonym: "nephrogenesis" RELATED [GOC:rph] is_a: GO:0048856 ! anatomical structure development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0001285 ! results in development of nephron relationship: BFO:0000050 GO:0001822 ! part of kidney development relationship: RO:0002296 UBERON:0001285 ! results in development of nephron creation_date: 2010-01-25T01:37:16Z [Term] id: GO:0072007 name: mesangial cell differentiation namespace: biological_process def: "The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the mesangial cells of the kidney as it progresses from its formation to the mature state." [GOC:mtg_kidney_jan10] is_a: GO:0061005 ! cell differentiation involved in kidney development is_a: GO:1904238 ! pericyte cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000650 ! results in acquisition of features of mesangial cell relationship: RO:0002315 CL:0000650 ! results in acquisition of features of mesangial cell creation_date: 2010-01-25T01:59:09Z [Term] id: GO:0072008 name: glomerular mesangial cell differentiation namespace: biological_process def: "The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the glomerular mesangial cells of the kidney as it progresses from its formation to the mature state." [GOC:mtg_kidney_jan10] is_a: GO:0035850 ! epithelial cell differentiation involved in kidney development is_a: GO:0072007 ! mesangial cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:1000742 ! results in acquisition of features of glomerular mesangial cell relationship: BFO:0000050 GO:0072109 ! part of glomerular mesangium development relationship: RO:0002315 CL:1000742 ! results in acquisition of features of glomerular mesangial cell creation_date: 2010-01-25T01:59:33Z [Term] id: GO:0072009 name: nephron epithelium development namespace: biological_process def: "The process whose specific outcome is the progression of the nephron epithelium over time, from its formation to the mature structure. An epithelium is a tissue that covers the internal or external surfaces of an anatomical structure. The nephron epithelium is a tissue that covers the surface of a nephron." [GOC:mtg_kidney_jan10] is_a: GO:0072073 ! kidney epithelium development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0004211 ! results in development of nephron epithelium relationship: BFO:0000050 GO:0072006 ! part of nephron development relationship: RO:0002296 UBERON:0004211 ! results in development of nephron epithelium creation_date: 2010-01-25T02:01:39Z [Term] id: GO:0072010 name: glomerular epithelium development namespace: biological_process def: "The process whose specific outcome is the progression of the glomerular epithelium over time, from its formation to the mature structure. The glomerular epithelium is an epithelial tissue that covers the outer surfaces of the glomerulus. The glomerular epithelium consists of both parietal and visceral epithelium. Metanephric glomerular parietal epithelial cells are specialized epithelial cells that form tight junctions as a barrier to protein transport. A metanephric glomerular visceral epithelial cell is a specialized epithelial cell that contains 'feet' that interdigitate with the 'feet' of other glomerular epithelial cells in the metanephros." [GOC:mtg_kidney_jan10] is_a: GO:0072009 ! nephron epithelium development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0004188 ! results in development of glomerular epithelium relationship: BFO:0000050 GO:0032835 ! part of glomerulus development relationship: RO:0002296 UBERON:0004188 ! results in development of glomerular epithelium creation_date: 2010-01-25T02:02:14Z [Term] id: GO:0072011 name: glomerular endothelium development namespace: biological_process def: "The process whose specific outcome is the progression of the glomerular endothelium over time, from its formation to the mature structure. The glomerular endothelium is an epithelial tissue that covers the internal surfaces of the glomerulus." [GOC:mtg_kidney_jan10] is_a: GO:0003158 ! endothelium development is_a: GO:0072010 ! glomerular epithelium development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0004189 ! results in development of glomerular endothelium relationship: BFO:0000050 GO:0072012 ! part of glomerulus vasculature development relationship: RO:0002296 UBERON:0004189 ! results in development of glomerular endothelium creation_date: 2010-01-25T02:02:57Z [Term] id: GO:0072012 name: glomerulus vasculature development namespace: biological_process def: "The biological process whose specific outcome is the progression of a glomerulus vasculature from an initial condition to its mature state. This process begins with the formation of the glomerulus vasculature and ends with the mature structure. The glomerulus vasculature is composed of the tubule structures that carry blood or lymph in the glomerulus." [GOC:mtg_kidney_jan10] synonym: "glomerulus capillary development" RELATED [GOC:mtg_kidney_jan10] is_a: GO:0001568 ! blood vessel development is_a: GO:0061440 ! kidney vasculature development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0004190 ! results in development of renal glomerulus vasculature relationship: BFO:0000050 GO:0032835 ! part of glomerulus development relationship: RO:0002296 UBERON:0004190 ! results in development of renal glomerulus vasculature creation_date: 2010-01-25T02:05:04Z [Term] id: GO:0072014 name: proximal tubule development namespace: biological_process def: "The process whose specific outcome is the progression of the proximal tubule over time, from its formation to the mature structure. In mammals, the proximal tubule is a nephron tubule that connects Bowman's capsule to the descending thin limb of the loop of Henle. It has a brush border epithelial morphology." [GOC:mtg_kidney_jan10] is_a: GO:0072080 ! nephron tubule development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0004134 ! results in development of proximal tubule relationship: RO:0002296 UBERON:0004134 ! results in development of proximal tubule creation_date: 2010-01-25T02:33:46Z [Term] id: GO:0072015 name: podocyte development namespace: biological_process def: "The process whose specific outcome is the progression of a glomerular visceral epithelial cell over time, from its formation to the mature structure. A glomerular visceral epithelial cell is a specialized epithelial cell that contains 'feet' that interdigitate with the 'feet' of other glomerular epithelial cells." [GOC:mtg_kidney_jan10] synonym: "glomerular visceral epithelial cell development" EXACT [] is_a: GO:0072310 ! glomerular epithelial cell development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 CL:0000653 ! results in development of podocyte relationship: BFO:0000050 GO:0072112 ! part of podocyte differentiation relationship: RO:0002296 CL:0000653 ! results in development of podocyte property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/23000" xsd:anyURI creation_date: 2010-01-25T02:12:45Z [Term] id: GO:0072016 name: glomerular parietal epithelial cell development namespace: biological_process def: "The process whose specific outcome is the progression of a glomerular parietal epithelial cell over time, from its formation to the mature structure. Glomerular parietal epithelial cells are specialized epithelial cells that form tight junctions as a barrier to protein transport." [GOC:mtg_kidney_jan10] synonym: "Bowman's capsule development" EXACT [GOC:mtg_kidney_jan10] is_a: GO:0072310 ! glomerular epithelial cell development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0001230 ! results in development of glomerular capsule relationship: BFO:0000050 GO:0072139 ! part of glomerular parietal epithelial cell differentiation relationship: RO:0002296 UBERON:0001230 ! results in development of glomerular capsule creation_date: 2010-01-25T02:13:16Z [Term] id: GO:0072017 name: distal tubule development namespace: biological_process def: "The process whose specific outcome is the progression of the distal tubule over time, from its formation to the mature structure. In mammals, the distal tubule is a nephron tubule that begins at the macula densa and extends to the connecting tubule." [GOC:mtg_kidney_jan10] is_a: GO:0072080 ! nephron tubule development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0004135 ! results in development of distal tubule relationship: RO:0002296 UBERON:0004135 ! results in development of distal tubule creation_date: 2010-01-25T02:34:19Z [Term] id: GO:0072019 name: proximal convoluted tubule development namespace: biological_process def: "The process whose specific outcome is the progression of the proximal convoluted tubule over time, from its formation to the mature structure. The proximal convoluted tubule is the most proximal portion of the proximal tubule and extends from the glomerular capsule to the proximal straight tubule." [GOC:mtg_kidney_jan10] is_a: GO:0072080 ! nephron tubule development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0001287 ! results in development of proximal convoluted tubule relationship: BFO:0000050 GO:0072014 ! part of proximal tubule development relationship: RO:0002296 UBERON:0001287 ! results in development of proximal convoluted tubule creation_date: 2010-01-25T02:35:35Z [Term] id: GO:0072020 name: proximal straight tubule development namespace: biological_process def: "The process whose specific outcome is the progression of the proximal straight tubule over time, from its formation to the mature structure. The proximal straight tubule is the part of the descending limb that extends from the proximal convoluted tubule to the descending thin tubule." [GOC:mtg_kidney_jan10] synonym: "S3 development" EXACT [GOC:mtg_kidney_jan10] is_a: GO:0072080 ! nephron tubule development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0001290 ! results in development of proximal straight tubule relationship: BFO:0000050 GO:0072014 ! part of proximal tubule development relationship: RO:0002296 UBERON:0001290 ! results in development of proximal straight tubule creation_date: 2010-01-25T02:36:14Z [Term] id: GO:0072021 name: ascending thin limb development namespace: biological_process def: "The process whose specific outcome is the progression of an ascending thin limb over time, from its formation to the mature structure. The ascending thin limb is a segment of a nephron tubule lying in the inner medulla that is permeable to ions but not to water and has a simple epithelium; active transepithelial solute transport is absent." [GOC:mtg_kidney_jan10] is_a: GO:0072080 ! nephron tubule development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0004193 ! results in development of loop of Henle ascending limb thin segment relationship: BFO:0000050 GO:0072070 ! part of loop of Henle development relationship: RO:0002296 UBERON:0004193 ! results in development of loop of Henle ascending limb thin segment creation_date: 2010-01-25T02:37:13Z [Term] id: GO:0072022 name: descending thin limb development namespace: biological_process def: "The process whose specific outcome is the progression of the descending thin limb over time, from its formation to the mature structure. The descending thin limb is a part of the loop of Henle situated just after the proximal straight tubule (S3). It extends to the tip of the loop of Henle." [GOC:mtg_kidney_jan10] is_a: GO:0048856 ! anatomical structure development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0005096 ! results in development of descending thin limb relationship: BFO:0000050 GO:0072070 ! part of loop of Henle development relationship: RO:0002296 UBERON:0005096 ! results in development of descending thin limb creation_date: 2010-01-25T02:37:47Z [Term] id: GO:0072023 name: thick ascending limb development namespace: biological_process def: "The process whose specific outcome is the progression of the thick ascending limb over time, from its formation to the mature structure. The thick ascending limb is the last part of the loop of Henle. Its thick, mitochondria-rich epithelium characterizes the outer medulla, and is responsible for very avid active salt transport. At the macula densa, the thick ascending limb connects to the distal convoluted tubule." [GOC:mtg_kidney_jan10] synonym: "TAL development" EXACT [GOC:mtg_kidney_jan10] is_a: GO:0072080 ! nephron tubule development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0001291 ! results in development of thick ascending limb of loop of Henle relationship: BFO:0000050 GO:0072017 ! part of distal tubule development relationship: RO:0002296 UBERON:0001291 ! results in development of thick ascending limb of loop of Henle creation_date: 2010-01-25T02:39:51Z [Term] id: GO:0072024 name: macula densa development namespace: biological_process def: "The process whose specific outcome is the progression of the macula densa over time, from its formation to the mature structure. The macula densa is an area of specialized cells in the distal tubule that makes contact with the vascular pole of the glomerulus." [GOC:mtg_kidney_jan10] is_a: GO:0072009 ! nephron epithelium development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0002335 ! results in development of macula densa relationship: BFO:0000050 GO:0072051 ! part of juxtaglomerular apparatus development relationship: RO:0002296 UBERON:0002335 ! results in development of macula densa creation_date: 2010-01-25T02:40:15Z [Term] id: GO:0072025 name: distal convoluted tubule development namespace: biological_process def: "The process whose specific outcome is the progression of the distal convoluted tubule over time, from its formation to the mature structure. The distal convoluted tubule is the first segment of the nephron lying just downstream from the loop of Henle, immediately after the macula densa. Among other functions, in humans it is responsible for the reabsorption of about 5% of filtered sodium via the thiazide-sensitive Na-Cl symporter." [GOC:mtg_kidney_jan10] is_a: GO:0072080 ! nephron tubule development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0001292 ! results in development of distal convoluted tubule relationship: BFO:0000050 GO:0072017 ! part of distal tubule development relationship: RO:0002296 UBERON:0001292 ! results in development of distal convoluted tubule creation_date: 2010-01-25T02:40:45Z [Term] id: GO:0072027 name: connecting tubule development namespace: biological_process def: "The process whose specific outcome is the progression of the connecting tubule over time, from its formation to the mature structure. The connecting tubule is a tubular segment of the nephron; it connects the distal convoluted tubule to the collecting duct." [GOC:mtg_kidney_jan10] synonym: "connecting duct development" EXACT [GOC:mtg_kidney_jan10] is_a: GO:0072080 ! nephron tubule development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0005097 ! results in development of renal connecting tubule relationship: RO:0002296 UBERON:0005097 ! results in development of renal connecting tubule creation_date: 2010-01-25T02:42:05Z [Term] id: GO:0072028 name: nephron morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the nephron are generated and organized. A nephron is the functional unit of the kidney." [GOC:mtg_kidney_jan10] is_a: BFO:0000003 is_a: GO:0009653 ! anatomical structure morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0001285 ! results in morphogenesis of nephron relationship: BFO:0000050 GO:0060993 ! part of kidney morphogenesis relationship: BFO:0000050 GO:0072006 ! part of nephron development relationship: RO:0002298 UBERON:0001285 ! results in morphogenesis of nephron creation_date: 2010-01-25T02:45:52Z [Term] id: GO:0072029 name: long nephron development namespace: biological_process def: "The process whose specific outcome is the progression of a long nephron over time, from its formation to the mature structure. Long nephrons are associated with juxtamedullary glomeruli and extend into the inner medulla." [GOC:mtg_kidney_jan10] synonym: "juxtamedullary nephron development" RELATED [GOC:mtg_kidney_jan10] is_a: GO:0072006 ! nephron development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0004194 ! results in development of long nephron relationship: RO:0002296 UBERON:0004194 ! results in development of long nephron creation_date: 2010-01-25T02:49:08Z [Term] id: GO:0072030 name: short nephron development namespace: biological_process def: "The process whose specific outcome is the progression of a short nephron over time, from its formation to the mature structure. Short nephrons are associated with mid-cortical and superficial glomeruli, are situated entirely in the outer medulla, and have no thin ascending limb." [GOC:mtg_kidney_jan10] is_a: GO:0072006 ! nephron development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0004195 ! results in development of short nephron relationship: RO:0002296 UBERON:0004195 ! results in development of short nephron creation_date: 2010-01-25T02:49:32Z [Term] id: GO:0072031 name: proximal convoluted tubule segment 1 development namespace: biological_process def: "The process whose specific outcome is the progression of the S1 portion of the proximal convoluted tubule over time, from its formation to the mature structure. The S1 portion is the initial portion of the proximal convoluted tubule and is responsible for avid reabsorption of water and solutes." [GOC:mtg_kidney_jan10, MA:0002612] synonym: "S1 development" EXACT [GOC:mtg_kidney_jan10] is_a: GO:0035295 ! tube development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0004196 ! results in development of proximal convoluted tubule segment 1 relationship: BFO:0000050 GO:0072019 ! part of proximal convoluted tubule development relationship: RO:0002296 UBERON:0004196 ! results in development of proximal convoluted tubule segment 1 creation_date: 2010-01-25T02:55:57Z [Term] id: GO:0072032 name: proximal convoluted tubule segment 2 development namespace: biological_process def: "The process whose specific outcome is the progression of the S2 portion of the proximal convoluted tubule over time, from its formation to the mature structure. The S2 portion of the tubule is involved in reabsorption of water and sodium chloride." [GOC:mtg_kidney_jan10, MA:0002613] synonym: "S2 development" EXACT [GOC:mtg_kidney_jan10] is_a: GO:0035295 ! tube development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0004197 ! results in development of proximal convoluted tubule segment 2 relationship: BFO:0000050 GO:0072019 ! part of proximal convoluted tubule development relationship: RO:0002296 UBERON:0004197 ! results in development of proximal convoluted tubule segment 2 creation_date: 2010-01-25T02:56:36Z [Term] id: GO:0072033 name: renal vesicle formation namespace: biological_process def: "The developmental process pertaining to the initial formation of the renal vesicle from condensed mesenchymal cells. The renal vesicle is the primordial structure of the nephron epithelium, and is formed by the condensation of mesenchymal cells." [GOC:mtg_kidney_jan10] synonym: "nephron epithelium formation" RELATED [GOC:mtg_kidney_jan10] is_a: BFO:0000003 is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0004209 ! results in formation of anatomical entity renal vesicle relationship: BFO:0000050 GO:0072077 ! part of renal vesicle morphogenesis relationship: RO:0002297 UBERON:0004209 ! results in formation of anatomical entity renal vesicle creation_date: 2010-01-25T02:57:03Z [Term] id: GO:0072036 name: mesenchymal to epithelial transition involved in renal vesicle formation namespace: biological_process def: "A transition where a mesenchymal cell establishes apical/basolateral polarity,forms intercellular adhesive junctions, synthesizes basement membrane components and becomes an epithelial cell that will contribute to the shaping of the renal vesicle." [GOC:mtg_kidney_jan10] is_a: GO:0035850 ! epithelial cell differentiation involved in kidney development is_a: GO:0060231 ! mesenchymal to epithelial transition intersection_of: GO:0060231 ! mesenchymal to epithelial transition intersection_of: BFO:0000050 GO:0072033 ! part of renal vesicle formation relationship: BFO:0000050 GO:0072033 ! part of renal vesicle formation creation_date: 2010-01-25T03:04:24Z [Term] id: GO:0072037 name: mesenchymal stem cell differentiation involved in nephron morphogenesis namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a mesenchymal stem cell that contributes to the shaping of a nephron. A mesenchymal stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized mesenchymal cells." [GOC:mtg_kidney_jan10] is_a: GO:0061005 ! cell differentiation involved in kidney development is_a: GO:0072497 ! mesenchymal stem cell differentiation intersection_of: GO:0072497 ! mesenchymal stem cell differentiation intersection_of: BFO:0000050 GO:0072028 ! part of nephron morphogenesis relationship: BFO:0000050 GO:0072028 ! part of nephron morphogenesis creation_date: 2010-01-25T03:07:39Z [Term] id: GO:0072038 name: mesenchymal stem cell maintenance involved in nephron morphogenesis namespace: biological_process def: "The process in which an organism retains a population of mesenchymal stem cells that contributes to the shaping of a nephron. A mesenchymal stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized mesenchymal cells." [GOC:mtg_kidney_jan10] is_a: GO:0035019 ! somatic stem cell population maintenance relationship: BFO:0000050 GO:0072028 ! part of nephron morphogenesis creation_date: 2010-01-25T03:08:05Z [Term] id: GO:0072039 name: regulation of mesenchymal cell apoptotic process involved in nephron morphogenesis namespace: biological_process def: "Any process that modulates the occurrence or rate of mesenchymal stem cell death by apoptotic process that contributes to the shaping of the nephron." [GOC:mtg_apoptosis, GOC:mtg_kidney_jan10] synonym: "regulation of mesenchymal stem cell apoptosis involved in nephron morphogenesis" NARROW [] synonym: "regulation of mesenchymal stem cell apoptotic process involved in nephron morphogenesis" EXACT [] is_a: GO:1902337 ! regulation of apoptotic process involved in morphogenesis is_a: GO:1904672 ! regulation of somatic stem cell population maintenance is_a: GO:2001053 ! regulation of mesenchymal cell apoptotic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:1901145 ! regulates mesenchymal cell apoptotic process involved in nephron morphogenesis relationship: RO:0002211 GO:0072038 ! regulates mesenchymal stem cell maintenance involved in nephron morphogenesis relationship: RO:0002211 GO:1901145 ! regulates mesenchymal cell apoptotic process involved in nephron morphogenesis creation_date: 2010-01-25T03:08:34Z [Term] id: GO:0072040 name: negative regulation of mesenchymal cell apoptotic process involved in nephron morphogenesis namespace: biological_process def: "Any process that reduces the occurrence or rate of mesenchymal stem cell death by apoptotic process that contributes to the shaping of the nephron." [GOC:mtg_apoptosis, GOC:mtg_kidney_jan10] synonym: "negative regulation of mesenchymal stem cell apoptosis involved in nephron morphogenesis" NARROW [] synonym: "negative regulation of mesenchymal stem cell apoptotic process involved in nephron morphogenesis" EXACT [] is_a: GO:0072039 ! regulation of mesenchymal cell apoptotic process involved in nephron morphogenesis is_a: GO:1902338 ! negative regulation of apoptotic process involved in morphogenesis is_a: GO:1904673 ! negative regulation of somatic stem cell population maintenance is_a: GO:2001054 ! negative regulation of mesenchymal cell apoptotic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:1901145 ! negatively regulates mesenchymal cell apoptotic process involved in nephron morphogenesis relationship: RO:0002212 GO:0072038 ! negatively regulates mesenchymal stem cell maintenance involved in nephron morphogenesis relationship: RO:0002212 GO:1901145 ! negatively regulates mesenchymal cell apoptotic process involved in nephron morphogenesis creation_date: 2010-01-25T03:09:30Z [Term] id: GO:0072041 name: positive regulation of mesenchymal cell apoptotic process involved in nephron morphogenesis namespace: biological_process def: "Any process that increases the occurrence or rate of mesenchymal stem cell death by apoptotic process that contributes to the shaping of the nephron." [GOC:mtg_apoptosis, GOC:mtg_kidney_jan10] synonym: "positive regulation of mesenchymal stem cell apoptosis involved in nephron morphogenesis" NARROW [] synonym: "positive regulation of mesenchymal stem cell apoptotic process involved in nephron morphogenesis" EXACT [] is_a: GO:0072039 ! regulation of mesenchymal cell apoptotic process involved in nephron morphogenesis is_a: GO:1902339 ! positive regulation of apoptotic process involved in morphogenesis is_a: GO:1904674 ! positive regulation of somatic stem cell population maintenance is_a: GO:2001055 ! positive regulation of mesenchymal cell apoptotic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:1901145 ! positively regulates mesenchymal cell apoptotic process involved in nephron morphogenesis relationship: RO:0002213 GO:0072038 ! positively regulates mesenchymal stem cell maintenance involved in nephron morphogenesis relationship: RO:0002213 GO:1901145 ! positively regulates mesenchymal cell apoptotic process involved in nephron morphogenesis creation_date: 2010-01-25T03:10:32Z [Term] id: GO:0072044 name: collecting duct development namespace: biological_process def: "The process whose specific outcome is the progression of a collecting duct over time, from its formation to the mature structure. The collecting duct responds to vasopressin and aldosterone to regulate water, electrolyte and acid-base balance. It is the final common path through which urine flows before entering the ureter and then emptying into the bladder." [GOC:mtg_kidney_jan10] is_a: GO:0035295 ! tube development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0001232 ! results in development of collecting duct of renal tubule relationship: BFO:0000050 GO:0001822 ! part of kidney development relationship: RO:0002296 UBERON:0001232 ! results in development of collecting duct of renal tubule creation_date: 2010-01-25T03:18:06Z [Term] id: GO:0072048 name: renal system pattern specification namespace: biological_process def: "Any developmental process that results in the creation of defined areas or spaces within an organism to which cells respond and eventually are instructed to differentiate into the anatomical structures of the renal system." [GOC:mtg_kidney_jan10] subset: gocheck_do_not_annotate synonym: "renal system pattern formation" RELATED [GOC:mtg_kidney_jan10] is_a: GO:0007389 ! pattern specification process relationship: BFO:0000050 GO:0072001 ! part of renal system development creation_date: 2010-01-25T03:31:51Z [Term] id: GO:0072049 name: comma-shaped body morphogenesis namespace: biological_process def: "The process in which the comma-shaped body is generated and organized. The comma-shaped body is the precursor structure to the S-shaped body that contributes to the morphogenesis of the nephron." [GOC:mtg_kidney_jan10] is_a: BFO:0000003 is_a: GO:0009653 ! anatomical structure morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0004198 ! results in morphogenesis of comma-shaped body relationship: BFO:0000050 GO:0072028 ! part of nephron morphogenesis relationship: RO:0002298 UBERON:0004198 ! results in morphogenesis of comma-shaped body creation_date: 2010-01-25T03:44:48Z [Term] id: GO:0072050 name: S-shaped body morphogenesis namespace: biological_process def: "The process in which the S-shaped body is generated and organized. The S-shaped body is the successor of the comma-shaped body that contributes to the morphogenesis of the nephron." [GOC:mtg_kidney_jan10] is_a: BFO:0000003 is_a: GO:0009653 ! anatomical structure morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0004199 ! results in morphogenesis of S-shaped body relationship: BFO:0000050 GO:0072028 ! part of nephron morphogenesis relationship: RO:0002298 UBERON:0004199 ! results in morphogenesis of S-shaped body creation_date: 2010-01-25T03:45:19Z [Term] id: GO:0072051 name: juxtaglomerular apparatus development namespace: biological_process def: "The process whose specific outcome is the progression of the juxtaglomerular apparatus over time, from its formation to the mature structure. The juxtaglomerular apparatus is an anatomical structure that lies adjacent to the glomerulus and regulates kidney function." [GOC:mtg_kidney_jan10] is_a: GO:0048856 ! anatomical structure development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0002303 ! results in development of juxtaglomerular apparatus relationship: BFO:0000050 GO:0001822 ! part of kidney development relationship: RO:0002296 UBERON:0002303 ! results in development of juxtaglomerular apparatus creation_date: 2010-01-25T03:52:23Z [Term] id: GO:0072052 name: juxtaglomerulus cell differentiation namespace: biological_process def: "The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the juxtaglomerulus cells of the kidney as it progresses from its formation to the mature state." [GOC:mtg_kidney_jan10] is_a: GO:0061005 ! cell differentiation involved in kidney development intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:1000618 ! results in acquisition of features of juxtaglomerular complex cell relationship: BFO:0000050 GO:0072051 ! part of juxtaglomerular apparatus development relationship: RO:0002315 CL:1000618 ! results in acquisition of features of juxtaglomerular complex cell creation_date: 2010-01-25T03:58:01Z [Term] id: GO:0072053 name: renal inner medulla development namespace: biological_process def: "The process whose specific outcome is the progression of the renal inner medulla over time, from its formation to the mature structure. The renal inner medulla is unique to mammalian kidneys and is the innermost region of the mammalian kidney." [GOC:mtg_kidney_jan10] synonym: "inner renal medulla development" EXACT [GOC:mtg_kidney_jan10] is_a: GO:0048856 ! anatomical structure development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0001294 ! results in development of inner medulla of kidney relationship: BFO:0000050 GO:0001822 ! part of kidney development relationship: RO:0002296 UBERON:0001294 ! results in development of inner medulla of kidney creation_date: 2010-01-25T03:59:37Z [Term] id: GO:0072054 name: renal outer medulla development namespace: biological_process def: "The process whose specific outcome is the progression of the renal outer medulla over time, from its formation to the mature structure. The renal outer medulla is the region of the kidney that lies between the renal cortex and the renal inner medulla." [GOC:mtg_kidney_jan10] synonym: "outer renal medulla development" EXACT [GOC:mtg_kidney_jan10] is_a: GO:0048856 ! anatomical structure development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0001293 ! results in development of outer medulla of kidney relationship: BFO:0000050 GO:0001822 ! part of kidney development relationship: RO:0002296 UBERON:0001293 ! results in development of outer medulla of kidney creation_date: 2010-01-25T04:00:42Z [Term] id: GO:0072055 name: renal cortex development namespace: biological_process def: "The process whose specific outcome is the progression of the renal cortex over time, from its formation to the mature structure. The renal cortex is the outer region of the kidney." [GOC:mtg_kidney_jan10] is_a: GO:0048856 ! anatomical structure development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0001225 ! results in development of cortex of kidney relationship: BFO:0000050 GO:0001822 ! part of kidney development relationship: RO:0002296 UBERON:0001225 ! results in development of cortex of kidney creation_date: 2010-01-25T04:01:12Z [Term] id: GO:0072056 name: pyramid development namespace: biological_process def: "The process whose specific outcome is the progression of the kidney pyramids over time, from its formation to the mature structure. Kidney pyramids are the conical masses that constitute the renal medulla in a multi-lobed mammalian kidney; they contain the loops of Henle and the medullary collecting ducts." [GOC:mtg_kidney_jan10] synonym: "kidney pyramid development" EXACT [GOC:mah] synonym: "pyramids development" EXACT [GOC:mah] synonym: "renal medulla development" EXACT [GOC:mah] synonym: "renal pyramid development" EXACT [GOC:mah] is_a: GO:0048856 ! anatomical structure development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0004200 ! results in development of kidney pyramid relationship: BFO:0000050 GO:0001822 ! part of kidney development relationship: RO:0002296 UBERON:0004200 ! results in development of kidney pyramid creation_date: 2010-01-25T04:01:36Z [Term] id: GO:0072057 name: inner stripe development namespace: biological_process def: "The process whose specific outcome is the progression of the inner stripe over time, from its formation to the mature structure. The inner stripe is a deep, centrally located portion of the renal outer medulla and is traversed by thin descending and thick ascending portions of the loops of Henle." [GOC:mtg_kidney_jan10] is_a: GO:0048856 ! anatomical structure development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0004201 ! results in development of kidney outer medulla inner stripe relationship: BFO:0000050 GO:0072054 ! part of renal outer medulla development relationship: RO:0002296 UBERON:0004201 ! results in development of kidney outer medulla inner stripe creation_date: 2010-01-25T04:01:58Z [Term] id: GO:0072058 name: outer stripe development namespace: biological_process def: "The process whose specific outcome is the progression of the outer stripe over time, from its formation to the mature structure. The outer stripe is the region of the kidney outer medulla that lies just below the cortex. The proximal straight tubules (S3) characterize this region." [GOC:mtg_kidney_jan10] is_a: GO:0048856 ! anatomical structure development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0004202 ! results in development of kidney outer medulla outer stripe relationship: BFO:0000050 GO:0072054 ! part of renal outer medulla development relationship: RO:0002296 UBERON:0004202 ! results in development of kidney outer medulla outer stripe creation_date: 2010-01-25T04:02:56Z [Term] id: GO:0072059 name: cortical collecting duct development namespace: biological_process def: "The process whose specific outcome is the progression of the cortical collecting duct over time, from its formation to the mature structure. The cortical collecting duct is the portion of the collecting duct that resides in the renal cortex." [GOC:mtg_kidney_jan10] is_a: GO:0048856 ! anatomical structure development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0004203 ! results in development of cortical collecting duct relationship: RO:0002162 NCBITaxon:7776 ! in taxon Gnathostomata relationship: RO:0002296 UBERON:0004203 ! results in development of cortical collecting duct creation_date: 2010-01-25T04:07:07Z [Term] id: GO:0072060 name: outer medullary collecting duct development namespace: biological_process def: "The process whose specific outcome is the progression of the outer medullary collecting duct over time, from its formation to the mature structure. The outer medullary collecting duct is the portion of the collecting duct that lies in the renal outer medulla." [GOC:mtg_kidney_jan10] is_a: GO:0072044 ! collecting duct development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0004204 ! results in development of outer medullary collecting duct relationship: RO:0002296 UBERON:0004204 ! results in development of outer medullary collecting duct creation_date: 2010-01-25T04:08:18Z [Term] id: GO:0072061 name: inner medullary collecting duct development namespace: biological_process def: "The process whose specific outcome is the progression of the inner medullary collecting duct over time, from its formation to the mature structure. The inner medullary collecting duct is the portion of the collecting duct that lies in the renal inner medulla." [GOC:mtg_kidney_jan10] is_a: GO:0072044 ! collecting duct development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0004205 ! results in development of inner medullary collecting duct relationship: RO:0002296 UBERON:0004205 ! results in development of inner medullary collecting duct creation_date: 2010-01-25T04:08:45Z [Term] id: GO:0072063 name: short descending thin limb development namespace: biological_process def: "The process whose specific outcome is the progression of the short descending thin limb over time, from its formation to the mature structure. The short descending thin limb is the descending thin limb of a short nephron that has a squamous epithelial morphology." [GOC:mtg_kidney_jan10] is_a: GO:0072009 ! nephron epithelium development is_a: GO:0072022 ! descending thin limb development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0005099 ! results in development of short descending thin limb relationship: BFO:0000050 GO:0072030 ! part of short nephron development relationship: RO:0002296 UBERON:0005099 ! results in development of short descending thin limb creation_date: 2010-01-25T04:12:39Z [Term] id: GO:0072064 name: long descending thin limb development namespace: biological_process def: "The process whose specific outcome is the progression of the long descending thin limb over time, from its formation to the mature structure. The long descending thin limb is the descending thin limb of a long nephron that has a squamous epithelial morphology. The long descending limb starts in the inner stripe of the outer medulla and extends into the inner medulla." [GOC:mtg_kidney_jan10] is_a: GO:0072009 ! nephron epithelium development is_a: GO:0072022 ! descending thin limb development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0005100 ! results in development of long descending thin limb relationship: BFO:0000050 GO:0072029 ! part of long nephron development relationship: RO:0002296 UBERON:0005100 ! results in development of long descending thin limb creation_date: 2010-01-25T04:13:17Z [Term] id: GO:0072067 name: early distal convoluted tubule development namespace: biological_process def: "The process whose specific outcome is the progression of the early distal convoluted tubule over time, from its formation to the mature structure. The early distal convoluted tubule contains DCT cells and is vasopressin-insensitive." [GOC:mtg_kidney_jan10] is_a: GO:0072009 ! nephron epithelium development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0005101 ! results in development of early distal convoluted tubule relationship: BFO:0000050 GO:0072025 ! part of distal convoluted tubule development relationship: RO:0002296 UBERON:0005101 ! results in development of early distal convoluted tubule creation_date: 2010-01-25T04:15:17Z [Term] id: GO:0072068 name: late distal convoluted tubule development namespace: biological_process def: "The process whose specific outcome is the progression of the late distal convoluted tubule over time, from its formation to the mature structure. The late distal convoluted tubule contains DCT cells and intercalated (IC) alpha and beta cells and is vasopressin-sensitive." [GOC:mtg_kidney_jan10] is_a: GO:0072009 ! nephron epithelium development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0005102 ! results in development of late distal convoluted tubule relationship: BFO:0000050 GO:0072025 ! part of distal convoluted tubule development relationship: RO:0002296 UBERON:0005102 ! results in development of late distal convoluted tubule creation_date: 2010-01-25T04:15:50Z [Term] id: GO:0072070 name: loop of Henle development namespace: biological_process def: "The process whose specific outcome is the progression of the loop of Henle over time, from its formation to the mature structure. The loop of Henle is a nephron tubule that connects the proximal convoluted tubule to the distal convoluted tubule." [GOC:mtg_kidney_jan10] synonym: "intermediate tubule development" EXACT [] is_a: GO:0072080 ! nephron tubule development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0001288 ! results in development of loop of Henle relationship: RO:0002296 UBERON:0001288 ! results in development of loop of Henle creation_date: 2010-01-25T04:20:27Z [Term] id: GO:0072071 name: kidney interstitial fibroblast differentiation namespace: biological_process def: "The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the interstitial fibroblast of the kidney as it progresses from its formation to the mature state." [GOC:mtg_kidney_jan10] synonym: "kidney interstitial cell differentiation" EXACT [GOC:mtg_kidney_jan10] is_a: GO:0061005 ! cell differentiation involved in kidney development intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:1000692 ! results in acquisition of features of kidney interstitial fibroblast relationship: RO:0002315 CL:1000692 ! results in acquisition of features of kidney interstitial fibroblast creation_date: 2010-01-25T04:34:31Z [Term] id: GO:0072073 name: kidney epithelium development namespace: biological_process def: "The process whose specific outcome is the progression of an epithelium in the kidney over time, from its formation to the mature structure. An epithelium is a tissue that covers the internal or external surfaces of an anatomical structure." [GOC:mtg_kidney_jan10] is_a: GO:0060429 ! epithelium development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0004819 ! results in development of kidney epithelium relationship: BFO:0000050 GO:0001822 ! part of kidney development relationship: RO:0002296 UBERON:0004819 ! results in development of kidney epithelium creation_date: 2010-01-25T04:37:42Z [Term] id: GO:0072074 name: kidney mesenchyme development namespace: biological_process def: "The biological process whose specific outcome is the progression of a kidney mesenchyme from an initial condition to its mature state. This process begins with the formation of kidney mesenchyme and ends with the mature structure. Kidney mesenchyme is the tissue made up of loosely connected mesenchymal cells in the kidney." [GOC:mtg_kidney_jan10] is_a: GO:0060485 ! mesenchyme development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0003918 ! results in development of kidney mesenchyme relationship: BFO:0000050 GO:0001822 ! part of kidney development relationship: RO:0002296 UBERON:0003918 ! results in development of kidney mesenchyme creation_date: 2010-01-25T04:39:04Z [Term] id: GO:0072075 name: metanephric mesenchyme development namespace: biological_process def: "The biological process whose specific outcome is the progression of a metanephric mesenchyme from an initial condition to its mature state. This process begins with the formation of metanephric mesenchyme and ends with the mature structure. Metanephric mesenchyme is the tissue made up of loosely connected mesenchymal cells in the metanephros." [GOC:mtg_kidney_jan10] is_a: GO:0072074 ! kidney mesenchyme development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0003220 ! results in development of metanephric mesenchyme relationship: BFO:0000050 GO:0001656 ! part of metanephros development relationship: RO:0002296 UBERON:0003220 ! results in development of metanephric mesenchyme creation_date: 2010-01-25T04:40:11Z [Term] id: GO:0072076 name: nephrogenic mesenchyme development namespace: biological_process def: "The biological process whose specific outcome is the progression of a nephrogenic mesenchyme from an initial condition to its mature state. This process begins with the formation of nephrogenic mesenchyme and ends with the mature structure. Nephrogenic mesenchyme is the tissue made up of loosely connected mesenchymal cells in the nephron." [GOC:mtg_kidney_jan10] is_a: GO:0072074 ! kidney mesenchyme development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0004208 ! results in development of nephrogenic mesenchyme relationship: BFO:0000050 GO:0072006 ! part of nephron development relationship: RO:0002296 UBERON:0004208 ! results in development of nephrogenic mesenchyme creation_date: 2010-01-25T04:40:44Z [Term] id: GO:0072077 name: renal vesicle morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the renal vesicle are generated and organized. The renal vesicle is the primordial structure of the nephron epithelium, and is formed by the condensation of mesenchymal cells." [GOC:mtg_kidney_jan10] is_a: GO:0002009 ! morphogenesis of an epithelium intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0004209 ! results in morphogenesis of renal vesicle relationship: BFO:0000050 GO:0072087 ! part of renal vesicle development relationship: BFO:0000050 GO:0072088 ! part of nephron epithelium morphogenesis relationship: RO:0002298 UBERON:0004209 ! results in morphogenesis of renal vesicle creation_date: 2010-02-01T02:21:06Z [Term] id: GO:0072078 name: nephron tubule morphogenesis namespace: biological_process def: "The process in which the anatomical structures of a nephron tubule are generated and organized. A nephron tubule is an epithelial tube that is part of the nephron, the functional part of the kidney." [GOC:mtg_kidney_jan10] is_a: GO:0061333 ! renal tubule morphogenesis is_a: GO:0072088 ! nephron epithelium morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0001231 ! results in morphogenesis of nephron tubule relationship: BFO:0000050 GO:0072080 ! part of nephron tubule development relationship: RO:0002298 UBERON:0001231 ! results in morphogenesis of nephron tubule creation_date: 2010-02-01T02:25:14Z [Term] id: GO:0072079 name: nephron tubule formation namespace: biological_process def: "The developmental process pertaining to the initial formation of a nephron tubule from unspecified parts. A nephron tubule is an epithelial tube that is part of the nephron, the functional part of the kidney." [GOC:mtg_kidney_jan10] is_a: GO:0001838 ! embryonic epithelial tube formation intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0001231 ! results in formation of anatomical entity nephron tubule relationship: BFO:0000050 GO:0072078 ! part of nephron tubule morphogenesis relationship: RO:0002297 UBERON:0001231 ! results in formation of anatomical entity nephron tubule creation_date: 2010-02-01T02:29:26Z [Term] id: GO:0072080 name: nephron tubule development namespace: biological_process def: "The progression of a nephron tubule over time, from its initial formation to the mature structure. A nephron tubule is an epithelial tube that is part of the nephron, the functional part of the kidney." [GOC:mtg_kidney_jan10] is_a: GO:0061326 ! renal tubule development is_a: GO:0072009 ! nephron epithelium development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0001231 ! results in development of nephron tubule relationship: RO:0002296 UBERON:0001231 ! results in development of nephron tubule creation_date: 2010-02-01T02:32:12Z [Term] id: GO:0072087 name: renal vesicle development namespace: biological_process def: "The process whose specific outcome is the progression of the renal vesicle over time, from its formation to the mature structure. An epithelium is a tissue that covers the internal or external surfaces of an anatomical structure. The renal vesicle is the primordial structure of the nephron epithelium, and is formed by the condensation of mesenchymal cells." [GOC:mtg_kidney_jan10] is_a: GO:0072073 ! kidney epithelium development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0004209 ! results in development of renal vesicle relationship: BFO:0000050 GO:0072009 ! part of nephron epithelium development relationship: RO:0002296 UBERON:0004209 ! results in development of renal vesicle creation_date: 2010-02-08T01:18:31Z [Term] id: GO:0072088 name: nephron epithelium morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the nephron epithelium are generated and organized. The nephron epithelium is a tissue that covers the surface of a nephron." [GOC:mtg_kidney_jan10] is_a: GO:0002009 ! morphogenesis of an epithelium intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0004211 ! results in morphogenesis of nephron epithelium relationship: BFO:0000050 GO:0072009 ! part of nephron epithelium development relationship: BFO:0000050 GO:0072028 ! part of nephron morphogenesis relationship: RO:0002298 UBERON:0004211 ! results in morphogenesis of nephron epithelium creation_date: 2010-02-08T01:19:06Z [Term] id: GO:0072089 name: stem cell proliferation namespace: biological_process def: "The multiplication or reproduction of stem cells, resulting in the expansion of a stem cell population. A stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells." [GOC:mtg_kidney_jan10] is_a: BFO:0000003 is_a: GO:0008283 ! cell population proliferation intersection_of: GO:0008283 ! cell population proliferation intersection_of: RO:0012003 CL:0000034 ! acts on population of stem cell relationship: BFO:0000051 GO:0017145 ! has part stem cell division relationship: RO:0012003 CL:0000034 ! acts on population of stem cell property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4751 creation_date: 2010-02-08T02:03:36Z [Term] id: GO:0072091 name: regulation of stem cell proliferation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of stem cell proliferation. A stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells." [GOC:mtg_kidney_jan10] is_a: GO:0042127 ! regulation of cell population proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0072089 ! regulates stem cell proliferation relationship: RO:0002211 GO:0072089 ! regulates stem cell proliferation property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4751 creation_date: 2010-02-08T02:09:03Z [Term] id: GO:0072093 name: metanephric renal vesicle formation namespace: biological_process def: "The developmental process pertaining to the initial formation of the metanephros." [GOC:mtg_kidney_jan10] synonym: "metanephros formation" EXACT [GOC:mtg_kidney_jan10] is_a: GO:0072033 ! renal vesicle formation intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0005147 ! results in formation of anatomical entity metanephric renal vesicle relationship: BFO:0000050 GO:0072283 ! part of metanephric renal vesicle morphogenesis relationship: RO:0002297 UBERON:0005147 ! results in formation of anatomical entity metanephric renal vesicle creation_date: 2010-02-10T01:17:11Z [Term] id: GO:0072098 name: anterior/posterior pattern specification involved in kidney development namespace: biological_process def: "The developmental process that results in the creation of defined areas or spaces within the kidney along the anterior/posterior axis to which cells respond and eventually are instructed to differentiate." [GOC:mtg_kidney_jan10] synonym: "anterior/posterior pattern formation involved in kidney development" RELATED [GOC:mtg_kidney_jan10] synonym: "kidney anterior/posterior pattern formation" RELATED [GOC:mtg_kidney_jan10] synonym: "kidney anterior/posterior pattern specification" EXACT [GOC:mtg_kidney_jan10] is_a: GO:0009952 ! anterior/posterior pattern specification is_a: GO:0061004 ! pattern specification involved in kidney development intersection_of: GO:0009952 ! anterior/posterior pattern specification intersection_of: BFO:0000050 GO:0001822 ! part of kidney development creation_date: 2010-02-10T02:06:24Z [Term] id: GO:0072099 name: anterior/posterior pattern specification involved in ureteric bud development namespace: biological_process def: "The developmental process that results in the creation of defined areas or spaces within the ureteric bud along the anterior/posterior axis to which cells respond and eventually are instructed to differentiate." [GOC:mtg_kidney_jan10] synonym: "ureteric bud anterior/posterior pattern formation" RELATED [GOC:mtg_kidney_jan10] is_a: GO:0061227 ! pattern specification involved in mesonephros development is_a: GO:0072098 ! anterior/posterior pattern specification involved in kidney development intersection_of: GO:0009952 ! anterior/posterior pattern specification intersection_of: BFO:0000050 GO:0001657 ! part of ureteric bud development relationship: BFO:0000050 GO:0001657 ! part of ureteric bud development creation_date: 2010-02-10T02:12:09Z [Term] id: GO:0072102 name: glomerulus morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the glomerulus are generated and organized. The glomerulus is a capillary tuft surrounded by Bowman's capsule in nephrons of the vertebrate kidney." [GOC:mtg_kidney_jan10] is_a: BFO:0000003 is_a: GO:0009653 ! anatomical structure morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0000074 ! results in morphogenesis of renal glomerulus relationship: BFO:0000050 GO:0032835 ! part of glomerulus development relationship: RO:0002298 UBERON:0000074 ! results in morphogenesis of renal glomerulus creation_date: 2010-02-10T02:32:09Z [Term] id: GO:0072103 name: glomerulus vasculature morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the glomerulus vasculature are generated and organized. The glomerulus vasculature is composed of the tubule structures that carry blood or lymph in the glomerulus." [GOC:mtg_kidney_jan10] is_a: GO:0048514 ! blood vessel morphogenesis is_a: GO:0061439 ! kidney vasculature morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0004190 ! results in morphogenesis of renal glomerulus vasculature relationship: BFO:0000050 GO:0072012 ! part of glomerulus vasculature development relationship: BFO:0000050 GO:0072102 ! part of glomerulus morphogenesis relationship: RO:0002298 UBERON:0004190 ! results in morphogenesis of renal glomerulus vasculature creation_date: 2010-02-10T02:34:54Z [Term] id: GO:0072104 name: glomerular capillary formation namespace: biological_process def: "The process that gives rise to a glomerular capillary. This process pertains to the initial formation of a structure from unspecified parts." [GOC:mtg_kidney_jan10] is_a: GO:0001525 ! angiogenesis intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0004212 ! results in formation of anatomical entity glomerular capillary relationship: BFO:0000050 GO:0072103 ! part of glomerulus vasculature morphogenesis relationship: RO:0002297 UBERON:0004212 ! results in formation of anatomical entity glomerular capillary creation_date: 2010-02-10T02:40:40Z [Term] id: GO:0072105 name: ureteric peristalsis namespace: biological_process def: "A wavelike sequence of involuntary muscular contraction and relaxation that passes along the ureter, impelling the contents onwards. The ureter is one of a pair of thick-walled tubes that transports urine from the kidney pelvis to the urinary bladder." [GOC:mtg_kidney_jan10] is_a: GO:0014849 ! ureter smooth muscle contraction is_a: GO:0030432 ! peristalsis intersection_of: GO:0030432 ! peristalsis intersection_of: BFO:0000066 UBERON:0000056 ! occurs in ureter relationship: BFO:0000066 UBERON:0000056 ! occurs in ureter property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 creation_date: 2010-02-10T03:07:54Z [Term] id: GO:0072106 name: regulation of ureteric bud formation namespace: biological_process def: "Any process that modulates the developmental process pertaining to the initial formation of the ureteric bud from the Wolffian duct." [GOC:mtg_kidney_jan10] is_a: GO:0061217 ! regulation of mesonephros development is_a: GO:1905276 ! regulation of epithelial tube formation is_a: GO:2000027 ! regulation of animal organ morphogenesis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0060676 ! regulates ureteric bud formation relationship: RO:0002211 GO:0060676 ! regulates ureteric bud formation creation_date: 2010-02-12T02:34:40Z [Term] id: GO:0072107 name: positive regulation of ureteric bud formation namespace: biological_process def: "Any process that increases the rate or extent of the developmental process pertaining to the initial formation of the ureteric bud from the Wolffian duct." [GOC:mtg_kidney_jan10] is_a: GO:0072106 ! regulation of ureteric bud formation is_a: GO:0110110 ! positive regulation of animal organ morphogenesis is_a: GO:1905278 ! positive regulation of epithelial tube formation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0060676 ! positively regulates ureteric bud formation relationship: RO:0002213 GO:0060676 ! positively regulates ureteric bud formation creation_date: 2010-02-12T02:37:28Z [Term] id: GO:0072108 name: positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis namespace: biological_process def: "Any process that increases the rate, frequency or extent of the transition where a mesenchymal cell establishes apical/basolateral polarity, forms intercellular adhesive junctions, synthesizes basement membrane components and becomes an epithelial cell that will contribute to the shaping of the metanephros." [GOC:mtg_kidney_jan10] is_a: GO:0003339 ! regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis is_a: GO:1905332 ! positive regulation of morphogenesis of an epithelium is_a: GO:2000698 ! positive regulation of epithelial cell differentiation involved in kidney development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0003337 ! positively regulates mesenchymal to epithelial transition involved in metanephros morphogenesis relationship: RO:0002213 GO:0003337 ! positively regulates mesenchymal to epithelial transition involved in metanephros morphogenesis creation_date: 2010-02-12T02:45:57Z [Term] id: GO:0072109 name: glomerular mesangium development namespace: biological_process def: "The process whose specific outcome is the progression of the glomerular mesangium over time, from its formation to the mature structure. The glomerular mesangium is the thin membrane connective tissue composed of mesangial cells, which helps to support the capillary loops in a renal glomerulus." [GOC:mtg_kidney_jan10] is_a: GO:0061448 ! connective tissue development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0002320 ! results in development of glomerular mesangium relationship: BFO:0000050 GO:0072012 ! part of glomerulus vasculature development relationship: RO:0002296 UBERON:0002320 ! results in development of glomerular mesangium creation_date: 2010-02-22T10:35:24Z [Term] id: GO:0072111 name: cell proliferation involved in kidney development namespace: biological_process def: "The multiplication or reproduction of cells, resulting in the expansion of the population in the kidney." [GOC:mtg_kidney_jan10] is_a: GO:0008283 ! cell population proliferation intersection_of: GO:0008283 ! cell population proliferation intersection_of: BFO:0000050 GO:0001822 ! part of kidney development relationship: BFO:0000050 GO:0001822 ! part of kidney development creation_date: 2010-02-22T10:48:45Z [Term] id: GO:0072112 name: podocyte differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a glomerular visceral epithelial cell. A glomerular visceral epithelial cell is a specialized epithelial cell that contains 'feet' that interdigitate with the 'feet' of other glomerular epithelial cells." [GOC:mtg_kidney_jan10] synonym: "glomerular visceral epithelial cell differentiation" EXACT [] is_a: GO:0061318 ! renal filtration cell differentiation is_a: GO:0072311 ! glomerular epithelial cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000653 ! results in acquisition of features of podocyte relationship: RO:0002315 CL:0000653 ! results in acquisition of features of podocyte property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/23000" xsd:anyURI creation_date: 2010-02-22T10:52:11Z [Term] id: GO:0072114 name: pronephros morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the pronephros are generated and organized. In mammals, the pronephros is the first of the three embryonic kidneys to be established and exists only transiently. In lower vertebrates such as fish and amphibia, the pronephros is the fully functional embryonic kidney and is indispensable for larval life." [GOC:mtg_kidney_jan10] synonym: "pronephric kidney morphogenesis" EXACT [GOC:mtg_kidney_jan10] is_a: GO:0060993 ! kidney morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0002120 ! results in morphogenesis of pronephros relationship: BFO:0000050 GO:0048793 ! part of pronephros development relationship: RO:0002298 UBERON:0002120 ! results in morphogenesis of pronephros creation_date: 2010-02-22T11:12:15Z [Term] id: GO:0072116 name: pronephros formation namespace: biological_process def: "The developmental process pertaining to the initial formation of the pronephros. In mammals, the pronephros is the first of the three embryonic kidneys to be established and exists only transiently. In lower vertebrates such as fish and amphibia, the pronephros is the fully functional embryonic kidney and is indispensable for larval life." [GOC:mtg_kidney_jan10] synonym: "pronephric kidney formation" EXACT [GOC:mtg_kidney_jan10] is_a: GO:0048645 ! animal organ formation is_a: GO:0072003 ! kidney rudiment formation intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0002120 ! results in formation of anatomical entity pronephros relationship: BFO:0000050 GO:0072114 ! part of pronephros morphogenesis relationship: RO:0002297 UBERON:0002120 ! results in formation of anatomical entity pronephros creation_date: 2010-02-22T11:16:26Z [Term] id: GO:0072120 name: pronephros maturation namespace: biological_process def: "A developmental process, independent of morphogenetic (shape) change, that is required for the pronephros to attain its fully functional state. In mammals, the pronephros is the first of the three embryonic kidneys to be established and exists only transiently. In lower vertebrates such as fish and amphibia, the pronephros is the fully functional embryonic kidney and is indispensable for larval life." [GOC:mtg_kidney_jan10] synonym: "pronephric kidney maturation" EXACT [GOC:mtg_kidney_jan10] is_a: GO:0048799 ! animal organ maturation intersection_of: GO:0021700 ! developmental maturation intersection_of: RO:0002299 UBERON:0002120 ! results in maturation of pronephros relationship: BFO:0000050 GO:0048793 ! part of pronephros development relationship: RO:0002299 UBERON:0002120 ! results in maturation of pronephros creation_date: 2010-02-22T11:25:48Z [Term] id: GO:0072127 name: renal capsule development namespace: biological_process def: "The process whose specific outcome is the progression of the renal capsule over time, from its formation to the mature structure. The renal capsule is the tough fibrous layer surrounding the kidney, covered in a thick layer of perinephric adipose tissue. It provides some protection from trauma and damage. During development, it comprises a single layer of flattened cells that lie just above the cortical stroma and the condensed mesenchyme of the nephrogenic zone. It is in this region that the early stages of nephron induction and formation of new generations ureteric bud branches occur, as the kidney expands." [GOC:mtg_kidney_jan10] is_a: GO:0061448 ! connective tissue development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0002015 ! results in development of kidney capsule relationship: BFO:0000050 GO:0001822 ! part of kidney development relationship: RO:0002296 UBERON:0002015 ! results in development of kidney capsule creation_date: 2010-02-22T02:02:55Z [Term] id: GO:0072128 name: renal capsule morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the renal capsule are generated and organized. The renal capsule is the tough fibrous layer surrounding the kidney, covered in a thick layer of perinephric adipose tissue. It provides some protection from trauma and damage. During development, it comprises a single layer of flattened cells that lie just above the cortical stroma and the condensed mesenchyme of the nephrogenic zone. It is in this region that the early stages of nephron induction and formation of new generations ureteric bud branches occur, as the kidney expands." [GOC:mtg_kidney_jan10] is_a: GO:0048729 ! tissue morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0002015 ! results in morphogenesis of kidney capsule relationship: BFO:0000050 GO:0072127 ! part of renal capsule development relationship: RO:0002298 UBERON:0002015 ! results in morphogenesis of kidney capsule creation_date: 2010-02-22T02:06:19Z [Term] id: GO:0072129 name: renal capsule formation namespace: biological_process def: "The developmental process pertaining to the initial formation of a renal capsule from unspecified parts. The renal capsule is the tough fibrous layer surrounding the kidney, covered in a thick layer of perinephric adipose tissue. It provides some protection from trauma and damage. During development, it comprises a single layer of flattened cells that lie just above the cortical stroma and the condensed mesenchyme of the nephrogenic zone. It is in this region that the early stages of nephron induction and formation of new generations ureteric bud branches occur, as the kidney expands." [GOC:mtg_kidney_jan10] is_a: BFO:0000003 is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0002015 ! results in formation of anatomical entity kidney capsule relationship: BFO:0000050 GO:0072128 ! part of renal capsule morphogenesis relationship: RO:0002297 UBERON:0002015 ! results in formation of anatomical entity kidney capsule creation_date: 2010-02-22T02:08:14Z [Term] id: GO:0072131 name: kidney mesenchyme morphogenesis namespace: biological_process def: "The process in which the anatomical structures of a kidney mesenchymal tissue are generated and organized. Kidney mesenchyme is the tissue made up of loosely connected mesenchymal cells in the kidney." [GOC:mtg_kidney_jan10] is_a: GO:0072132 ! mesenchyme morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0003918 ! results in morphogenesis of kidney mesenchyme relationship: BFO:0000050 GO:0072074 ! part of kidney mesenchyme development relationship: RO:0002298 UBERON:0003918 ! results in morphogenesis of kidney mesenchyme creation_date: 2010-02-22T02:16:43Z [Term] id: GO:0072132 name: mesenchyme morphogenesis namespace: biological_process def: "The process in which the anatomical structures of a mesenchymal tissue are generated and organized. A mesenchymal tissue is made up of loosely packed stellate cells." [GOC:mtg_kidney_jan10] is_a: GO:0048729 ! tissue morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0003104 ! results in morphogenesis of mesenchyme relationship: BFO:0000050 GO:0009887 ! part of animal organ morphogenesis relationship: BFO:0000050 GO:0060485 ! part of mesenchyme development relationship: RO:0002298 UBERON:0003104 ! results in morphogenesis of mesenchyme creation_date: 2010-02-22T02:17:15Z [Term] id: GO:0072133 name: metanephric mesenchyme morphogenesis namespace: biological_process def: "The process in which the anatomical structures of a metanephric mesenchymal tissue are generated and organized. Metanephric mesenchyme is the tissue made up of loosely connected mesenchymal cells in the metanephros." [GOC:mtg_kidney_jan10] is_a: GO:0072131 ! kidney mesenchyme morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0003220 ! results in morphogenesis of metanephric mesenchyme relationship: BFO:0000050 GO:0072075 ! part of metanephric mesenchyme development relationship: RO:0002298 UBERON:0003220 ! results in morphogenesis of metanephric mesenchyme creation_date: 2010-02-22T02:20:14Z [Term] id: GO:0072134 name: nephrogenic mesenchyme morphogenesis namespace: biological_process def: "The process in which the anatomical structures of a nephrogenic mesenchymal tissue are generated and organized. Nephrogenic mesenchyme is the tissue made up of loosely connected mesenchymal cells in the nephron." [GOC:mtg_kidney_jan10] is_a: GO:0072131 ! kidney mesenchyme morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0004208 ! results in morphogenesis of nephrogenic mesenchyme relationship: BFO:0000050 GO:0072076 ! part of nephrogenic mesenchyme development relationship: RO:0002298 UBERON:0004208 ! results in morphogenesis of nephrogenic mesenchyme creation_date: 2010-02-22T02:21:16Z [Term] id: GO:0072138 name: mesenchymal cell proliferation involved in ureteric bud development namespace: biological_process def: "The multiplication or reproduction of cells, resulting in the expansion of a mesenchymal cell population of the ureteric bud, that contributes to ureteric bud development." [GOC:mtg_kidney_jan10] synonym: "ureteric bud mesenchymal cell proliferation" BROAD [GOC:mtg_kidney_jan10] is_a: GO:0010463 ! mesenchymal cell proliferation is_a: GO:0061209 ! cell proliferation involved in mesonephros development intersection_of: GO:0010463 ! mesenchymal cell proliferation intersection_of: BFO:0000050 GO:0001657 ! part of ureteric bud development relationship: BFO:0000050 GO:0001657 ! part of ureteric bud development creation_date: 2010-02-22T02:40:38Z [Term] id: GO:0072139 name: glomerular parietal epithelial cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a glomerular parietal epithelial cell. Glomerular parietal epithelial cells are specialized epithelial cells that form tight junctions as a barrier to protein transport." [GOC:mtg_kidney_jan10] is_a: GO:0072311 ! glomerular epithelial cell differentiation creation_date: 2010-02-24T01:33:05Z [Term] id: GO:0072141 name: renal interstitial fibroblast development namespace: biological_process def: "The process whose specific outcome is the progression of a renal interstitial fibroblast over time, from its formation to the mature structure." [GOC:mtg_kidney_jan10] synonym: "kidney interstitial cell development" EXACT [GOC:mtg_kidney_jan10] is_a: GO:0048468 ! cell development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 CL:1000692 ! results in development of kidney interstitial fibroblast relationship: BFO:0000050 GO:0072071 ! part of kidney interstitial fibroblast differentiation relationship: RO:0002296 CL:1000692 ! results in development of kidney interstitial fibroblast creation_date: 2010-02-24T01:39:05Z [Term] id: GO:0072142 name: juxtaglomerulus cell development namespace: biological_process def: "The process whose specific outcome is the progression of a juxtaglomerulus cell over time, from its formation to the mature structure." [GOC:mtg_kidney_jan10] is_a: GO:0048468 ! cell development intersection_of: GO:0048468 ! cell development intersection_of: RO:0002296 CL:1000618 ! results in development of juxtaglomerular complex cell relationship: BFO:0000050 GO:0072052 ! part of juxtaglomerulus cell differentiation relationship: RO:0002296 CL:1000618 ! results in development of juxtaglomerular complex cell creation_date: 2010-02-24T01:42:53Z [Term] id: GO:0072143 name: mesangial cell development namespace: biological_process def: "The process whose specific outcome is the progression of a mesangial cell in the kidney over time, from its formation to the mature structure." [GOC:mtg_kidney_jan10] is_a: GO:0048468 ! cell development intersection_of: GO:0032502 ! developmental process intersection_of: RO:0002296 CL:0000650 ! results in development of mesangial cell relationship: BFO:0000050 GO:0072007 ! part of mesangial cell differentiation relationship: RO:0002296 CL:0000650 ! results in development of mesangial cell creation_date: 2010-02-24T01:44:28Z [Term] id: GO:0072144 name: glomerular mesangial cell development namespace: biological_process def: "The process whose specific outcome is the progression of a glomerular mesangial cell in the kidney over time, from its formation to the mature structure." [GOC:mtg_kidney_jan10] is_a: GO:0002064 ! epithelial cell development is_a: GO:0072143 ! mesangial cell development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 CL:1000742 ! results in development of glomerular mesangial cell relationship: BFO:0000050 GO:0072008 ! part of glomerular mesangial cell differentiation relationship: RO:0002296 CL:1000742 ! results in development of glomerular mesangial cell creation_date: 2010-02-24T01:53:13Z [Term] id: GO:0072155 name: epithelial cell migration involved in nephron tubule morphogenesis namespace: biological_process def: "The orderly movement of epithelial cells within a renal tubule that contributes to nephron tubule morphogenesis." [GOC:mtg_kidney_jan10] is_a: GO:0010631 ! epithelial cell migration is_a: GO:0035787 ! cell migration involved in kidney development intersection_of: GO:0010631 ! epithelial cell migration intersection_of: BFO:0000050 GO:0072078 ! part of nephron tubule morphogenesis relationship: BFO:0000050 GO:0072078 ! part of nephron tubule morphogenesis creation_date: 2010-02-24T02:21:25Z [Term] id: GO:0072156 name: distal tubule morphogenesis namespace: biological_process def: "The process in which the anatomical structures of a distal tubule are generated and organized. The distal tubule is a nephron tubule that begins at the macula densa and extends to the connecting tubule." [GOC:mtg_kidney_jan10] is_a: GO:0072078 ! nephron tubule morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0004135 ! results in morphogenesis of distal tubule relationship: BFO:0000050 GO:0072017 ! part of distal tubule development relationship: RO:0002298 UBERON:0004135 ! results in morphogenesis of distal tubule creation_date: 2010-02-24T02:32:03Z [Term] id: GO:0072157 name: epithelial cell migration involved in distal tubule morphogenesis namespace: biological_process def: "The orderly movement of epithelial cells within a renal tubule that contributes to distal tubule morphogenesis." [GOC:mtg_kidney_jan10] is_a: GO:0072155 ! epithelial cell migration involved in nephron tubule morphogenesis intersection_of: GO:0010631 ! epithelial cell migration intersection_of: BFO:0000050 GO:0072156 ! part of distal tubule morphogenesis relationship: BFO:0000050 GO:0072156 ! part of distal tubule morphogenesis creation_date: 2010-02-24T02:33:33Z [Term] id: GO:0072158 name: proximal tubule morphogenesis namespace: biological_process def: "The process in which the anatomical structures of a proximal tubule are generated and organized. The proximal tubule is a nephron tubule that connects Bowman's capsule to the descending thin limb of the loop of Henle. It has a brush border epithelial morphology." [GOC:mtg_kidney_jan10] is_a: GO:0072078 ! nephron tubule morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0004134 ! results in morphogenesis of proximal tubule relationship: BFO:0000050 GO:0072014 ! part of proximal tubule development relationship: RO:0002298 UBERON:0004134 ! results in morphogenesis of proximal tubule creation_date: 2010-02-24T02:35:36Z [Term] id: GO:0072159 name: epithelial cell migration involved in proximal tubule morphogenesis namespace: biological_process def: "The orderly movement of epithelial cells within a renal tubule that contributes to proximal tubule morphogenesis." [GOC:mtg_kidney_jan10] is_a: GO:0072155 ! epithelial cell migration involved in nephron tubule morphogenesis intersection_of: GO:0010631 ! epithelial cell migration intersection_of: BFO:0000050 GO:0072158 ! part of proximal tubule morphogenesis relationship: BFO:0000050 GO:0072158 ! part of proximal tubule morphogenesis creation_date: 2010-02-24T02:37:08Z [Term] id: GO:0072160 name: nephron tubule epithelial cell differentiation namespace: biological_process def: "The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the cells of the nephron tubule as it progresses from its formation to the mature state." [GOC:mtg_kidney_jan10] is_a: GO:0035850 ! epithelial cell differentiation involved in kidney development intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:1000494 ! results in acquisition of features of nephron tubule epithelial cell relationship: BFO:0000050 GO:0072080 ! part of nephron tubule development relationship: RO:0002315 CL:1000494 ! results in acquisition of features of nephron tubule epithelial cell creation_date: 2010-02-24T02:40:11Z [Term] id: GO:0072161 name: mesenchymal cell differentiation involved in kidney development namespace: biological_process def: "The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the mesenchymal cells of the kidney as it progresses from its formation to the mature state." [GOC:mtg_kidney_jan10] is_a: GO:0061005 ! cell differentiation involved in kidney development is_a: GO:2001012 ! mesenchymal cell differentiation involved in renal system development intersection_of: GO:0048762 ! mesenchymal cell differentiation intersection_of: BFO:0000050 GO:0001822 ! part of kidney development relationship: BFO:0000050 GO:0072074 ! part of kidney mesenchyme development creation_date: 2010-02-26T01:31:49Z [Term] id: GO:0072163 name: mesonephric epithelium development namespace: biological_process def: "The process whose specific outcome is the progression of an epithelium in the mesonephros over time, from its formation to the mature structure. An epithelium is a tissue that covers the internal or external surfaces of an anatomical structure." [GOC:mtg_kidney_jan10] is_a: GO:0072073 ! kidney epithelium development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0005103 ! results in development of mesonephric epithelium relationship: BFO:0000050 GO:0001823 ! part of mesonephros development relationship: RO:0002296 UBERON:0005103 ! results in development of mesonephric epithelium creation_date: 2010-02-26T01:40:43Z [Term] id: GO:0072164 name: mesonephric tubule development namespace: biological_process def: "The progression of a mesonephric tubule over time, from its initial formation to the mature structure. A mesonephric tubule is an epithelial tube that is part of the mesonephros." [GOC:mtg_kidney_jan10] is_a: GO:0035295 ! tube development is_a: GO:0072163 ! mesonephric epithelium development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0000083 ! results in development of mesonephric tubule relationship: RO:0002296 UBERON:0000083 ! results in development of mesonephric tubule creation_date: 2010-02-26T01:45:58Z [Term] id: GO:0072170 name: metanephric tubule development namespace: biological_process def: "The progression of a metanephric tubule over time, from its initial formation to the mature structure. A metanephric tubule is an epithelial tube that is part of the metanephros." [GOC:mtg_kidney_jan10] is_a: GO:0035295 ! tube development is_a: GO:0072207 ! metanephric epithelium development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0005106 ! results in development of metanephric tubule relationship: RO:0002296 UBERON:0005106 ! results in development of metanephric tubule creation_date: 2010-02-26T01:58:18Z [Term] id: GO:0072171 name: mesonephric tubule morphogenesis namespace: biological_process def: "The process in which the anatomical structures of a mesonephric tubule are generated and organized. A mesonephric tubule is an epithelial tube that is part of the mesonephros." [GOC:mtg_kidney_jan10] is_a: GO:0072078 ! nephron tubule morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0000083 ! results in morphogenesis of mesonephric tubule relationship: BFO:0000050 GO:0072164 ! part of mesonephric tubule development relationship: RO:0002298 UBERON:0000083 ! results in morphogenesis of mesonephric tubule creation_date: 2010-02-26T02:02:13Z [Term] id: GO:0072172 name: mesonephric tubule formation namespace: biological_process def: "The developmental process pertaining to the initial formation of a mesonephric tubule from unspecified parts. A mesonephric tubule is an epithelial tube that is part of the mesonephros." [GOC:mtg_kidney_jan10] is_a: GO:0072079 ! nephron tubule formation intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0000083 ! results in formation of anatomical entity mesonephric tubule relationship: BFO:0000050 GO:0072171 ! part of mesonephric tubule morphogenesis relationship: RO:0002297 UBERON:0000083 ! results in formation of anatomical entity mesonephric tubule creation_date: 2010-02-26T02:02:37Z [Term] id: GO:0072173 name: metanephric tubule morphogenesis namespace: biological_process def: "The process in which the anatomical structures of a metanephric tubule are generated and organized from an epithelium. A metanephric tubule is an epithelial tube that is part of the metanephros." [GOC:mtg_kidney_jan10] is_a: GO:0060562 ! epithelial tube morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0005106 ! results in morphogenesis of metanephric tubule relationship: BFO:0000050 GO:0072170 ! part of metanephric tubule development relationship: RO:0002298 UBERON:0005106 ! results in morphogenesis of metanephric tubule creation_date: 2010-02-26T02:06:42Z [Term] id: GO:0072174 name: metanephric tubule formation namespace: biological_process def: "The developmental process pertaining to the initial formation of a metanephric tubule." [GOC:mtg_kidney_jan10] is_a: GO:0072175 ! epithelial tube formation intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0005106 ! results in formation of anatomical entity metanephric tubule relationship: BFO:0000050 GO:0072173 ! part of metanephric tubule morphogenesis relationship: RO:0002297 UBERON:0005106 ! results in formation of anatomical entity metanephric tubule creation_date: 2010-02-26T02:07:41Z [Term] id: GO:0072175 name: epithelial tube formation namespace: biological_process def: "The developmental process pertaining to the initial formation of an epithelial tube." [GOC:mtg_kidney_jan10] is_a: GO:0035148 ! tube formation intersection_of: GO:0035148 ! tube formation intersection_of: RO:0002297 UBERON:0003914 ! results in formation of anatomical entity epithelial tube relationship: BFO:0000050 GO:0060562 ! part of epithelial tube morphogenesis relationship: RO:0002297 UBERON:0003914 ! results in formation of anatomical entity epithelial tube property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/22302" xsd:anyURI creation_date: 2010-02-26T02:15:40Z [Term] id: GO:0072176 name: nephric duct development namespace: biological_process def: "The process whose specific outcome is the progression of a nephric duct over time, from its initial formation to a mature structure. A nephric duct is a tube that drains a primitive kidney." [GOC:mtg_kidney_jan10] is_a: GO:0035295 ! tube development is_a: GO:0072073 ! kidney epithelium development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0009201 ! results in development of nephric duct relationship: RO:0002296 UBERON:0009201 ! results in development of nephric duct creation_date: 2010-02-26T02:27:31Z [Term] id: GO:0072177 name: mesonephric duct development namespace: biological_process def: "The process whose specific outcome is the progression of a mesonephric duct over time, from its initial formation to a mature structure. A mesonephric duct is a tube drains the mesonephros." [GOC:mtg_kidney_jan10] synonym: "Wolffian duct development" EXACT [GOC:dph] is_a: GO:0072164 ! mesonephric tubule development is_a: GO:0072176 ! nephric duct development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0003074 ! results in development of mesonephric duct relationship: RO:0002296 UBERON:0003074 ! results in development of mesonephric duct creation_date: 2010-02-26T02:32:22Z [Term] id: GO:0072178 name: nephric duct morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the nephric duct are generated and organized. A nephric duct is a tube that drains a primitive kidney." [GOC:mtg_kidney_jan10] is_a: GO:0060562 ! epithelial tube morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0009201 ! results in morphogenesis of nephric duct relationship: BFO:0000050 GO:0072176 ! part of nephric duct development relationship: RO:0002298 UBERON:0009201 ! results in morphogenesis of nephric duct creation_date: 2010-02-26T02:35:29Z [Term] id: GO:0072179 name: nephric duct formation namespace: biological_process def: "The developmental process pertaining to the initial formation of a nephric duct. A nephric duct is a tube that drains a primitive kidney." [GOC:mtg_kidney_jan10] xref: Reactome:R-HSA-9830364 "Formation of the nephric duct" is_a: GO:0072175 ! epithelial tube formation intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0009201 ! results in formation of anatomical entity nephric duct relationship: BFO:0000050 GO:0072178 ! part of nephric duct morphogenesis relationship: RO:0002297 UBERON:0009201 ! results in formation of anatomical entity nephric duct creation_date: 2010-02-26T02:35:55Z [Term] id: GO:0072180 name: mesonephric duct morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the mesonephric duct are generated and organized. A mesonephric duct is a tube drains the mesonephros." [GOC:mtg_kidney_jan10] synonym: "Wolffian duct morphogenesis" RELATED [GOC:dph] is_a: GO:0072171 ! mesonephric tubule morphogenesis is_a: GO:0072178 ! nephric duct morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0003074 ! results in morphogenesis of mesonephric duct relationship: BFO:0000050 GO:0072177 ! part of mesonephric duct development relationship: RO:0002298 UBERON:0003074 ! results in morphogenesis of mesonephric duct creation_date: 2010-02-26T02:37:13Z [Term] id: GO:0072181 name: mesonephric duct formation namespace: biological_process def: "The developmental process pertaining to the initial formation of a mesonephric duct. A mesonephric duct is a tube that drains the mesonephros." [GOC:mtg_kidney_jan10] synonym: "Wolffian duct formation" EXACT [GOC:dph] is_a: GO:0072172 ! mesonephric tubule formation is_a: GO:0072179 ! nephric duct formation is_a: GO:0072180 ! mesonephric duct morphogenesis intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0003074 ! results in formation of anatomical entity mesonephric duct relationship: RO:0002297 UBERON:0003074 ! results in formation of anatomical entity mesonephric duct creation_date: 2010-02-26T02:38:03Z [Term] id: GO:0072182 name: regulation of nephron tubule epithelial cell differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of nephron tubule epithelial cell differentiation." [GOC:mtg_kidney_jan10] is_a: GO:2000696 ! regulation of epithelial cell differentiation involved in kidney development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0072160 ! regulates nephron tubule epithelial cell differentiation relationship: RO:0002211 GO:0072160 ! regulates nephron tubule epithelial cell differentiation creation_date: 2010-02-26T02:45:09Z [Term] id: GO:0072183 name: negative regulation of nephron tubule epithelial cell differentiation namespace: biological_process def: "Any process that decreases the frequency, rate or extent of nephron tubule epithelial cell differentiation." [GOC:mtg_kidney_jan10] is_a: GO:0072182 ! regulation of nephron tubule epithelial cell differentiation is_a: GO:0090185 ! negative regulation of kidney development is_a: GO:2000697 ! negative regulation of epithelial cell differentiation involved in kidney development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0072160 ! negatively regulates nephron tubule epithelial cell differentiation relationship: RO:0002212 GO:0072160 ! negatively regulates nephron tubule epithelial cell differentiation creation_date: 2010-02-26T02:47:25Z [Term] id: GO:0072189 name: ureter development namespace: biological_process def: "The process whose specific outcome is the progression of the ureter over time, from its formation to the mature structure. The ureter is a muscular tube that transports urine from the kidney to the urinary bladder or from the Malpighian tubule to the hindgut." [GOC:mtg_kidney_jan10] is_a: GO:0035295 ! tube development is_a: GO:0048513 ! animal organ development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0000056 ! results in development of ureter relationship: BFO:0000050 GO:0072001 ! part of renal system development relationship: RO:0002162 NCBITaxon:7776 ! in taxon Gnathostomata relationship: RO:0002296 UBERON:0000056 ! results in development of ureter creation_date: 2010-03-01T01:44:14Z [Term] id: GO:0072190 name: ureter urothelium development namespace: biological_process def: "The process whose specific outcome is the progression of the urothelium of the ureter over time, from its formation to the mature structure. The urothelium is an epithelium that makes up the epithelial tube of the ureter." [GOC:mtg_kidney_jan10] synonym: "ureter epithelium development" EXACT [GOC:mtg_kidney_jan10] is_a: GO:0060429 ! epithelium development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0001254 ! results in development of urothelium of ureter relationship: BFO:0000050 GO:0072189 ! part of ureter development relationship: RO:0002296 UBERON:0001254 ! results in development of urothelium of ureter creation_date: 2010-03-01T01:46:31Z [Term] id: GO:0072191 name: ureter smooth muscle development namespace: biological_process def: "The process whose specific outcome is the progression of smooth muscle in the ureter over time, from its formation to the mature structure." [GOC:mtg_kidney_jan10] is_a: GO:0048745 ! smooth muscle tissue development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0009919 ! results in development of ureter smooth muscle relationship: BFO:0000050 GO:0072189 ! part of ureter development relationship: RO:0002296 UBERON:0009919 ! results in development of ureter smooth muscle creation_date: 2010-03-01T01:48:53Z [Term] id: GO:0072193 name: ureter smooth muscle cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a smooth muscle cell in the ureter." [GOC:mtg_kidney_jan10] is_a: GO:0051145 ! smooth muscle cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:1000979 ! results in acquisition of features of ureter smooth muscle cell relationship: BFO:0000050 GO:0072191 ! part of ureter smooth muscle development relationship: RO:0002315 CL:1000979 ! results in acquisition of features of ureter smooth muscle cell creation_date: 2010-03-01T01:55:01Z [Term] id: GO:0072194 name: kidney smooth muscle tissue development namespace: biological_process def: "The process whose specific outcome is the progression of smooth muscle in the kidney over time, from its formation to the mature structure." [GOC:mtg_kidney_jan10] is_a: GO:0048745 ! smooth muscle tissue development relationship: BFO:0000050 GO:0001822 ! part of kidney development creation_date: 2010-03-01T02:05:30Z [Term] id: GO:0072197 name: ureter morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the ureter are generated and organized. The ureter is a muscular tube that transports urine from the kidney to the urinary bladder." [GOC:mtg_kidney_jan10] is_a: GO:0009887 ! animal organ morphogenesis is_a: GO:0035239 ! tube morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0000056 ! results in morphogenesis of ureter relationship: BFO:0000050 GO:0072189 ! part of ureter development relationship: RO:0002298 UBERON:0000056 ! results in morphogenesis of ureter creation_date: 2010-03-01T02:24:55Z [Term] id: GO:0072198 name: mesenchymal cell proliferation involved in ureter development namespace: biological_process def: "The multiplication or reproduction of cells, resulting in the expansion of a mesenchymal cell population of the ureter, that contributes to ureter development." [GOC:mtg_kidney_jan10] synonym: "ureter mesenchymal cell proliferation" RELATED [GOC:mtg_kidney_jan10] synonym: "ureteral mesenchymal cell proliferation" RELATED [GOC:mtg_kidney_jan10] is_a: GO:0010463 ! mesenchymal cell proliferation intersection_of: GO:0010463 ! mesenchymal cell proliferation intersection_of: BFO:0000050 GO:0072189 ! part of ureter development relationship: BFO:0000050 GO:0072189 ! part of ureter development creation_date: 2010-03-01T03:24:41Z [Term] id: GO:0072199 name: regulation of mesenchymal cell proliferation involved in ureter development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of mesenchymal cell proliferation that contributes to the progression of the ureter gland over time. A mesenchymal cell is a cell that normally gives rise to other cells that are organized as three-dimensional masses, rather than sheets." [GOC:mtg_kidney_jan10] synonym: "regulation of ureter mesenchymal cell proliferation" RELATED [GOC:mtg_kidney_jan10] synonym: "regulation of ureteral mesenchymal cell proliferation" RELATED [GOC:mtg_kidney_jan10] is_a: GO:0010464 ! regulation of mesenchymal cell proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0072198 ! regulates mesenchymal cell proliferation involved in ureter development relationship: RO:0002211 GO:0072198 ! regulates mesenchymal cell proliferation involved in ureter development creation_date: 2010-03-01T03:38:13Z [Term] id: GO:0072200 name: negative regulation of mesenchymal cell proliferation involved in ureter development namespace: biological_process def: "Any process that decreases the frequency, rate or extent of mesenchymal cell proliferation that contributes to the progression of the ureter gland over time. A mesenchymal cell is a cell that normally gives rise to other cells that are organized as three-dimensional masses, rather than sheets." [GOC:mtg_kidney_jan10] synonym: "negative regulation of ureter mesenchymal cell proliferation" RELATED [GOC:mtg_kidney_jan10] synonym: "negative regulation of ureteral mesenchymal cell proliferation" RELATED [GOC:mtg_kidney_jan10] is_a: GO:0051093 ! negative regulation of developmental process is_a: GO:0051241 ! negative regulation of multicellular organismal process is_a: GO:0072199 ! regulation of mesenchymal cell proliferation involved in ureter development is_a: GO:0072201 ! negative regulation of mesenchymal cell proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0072198 ! negatively regulates mesenchymal cell proliferation involved in ureter development relationship: RO:0002212 GO:0072198 ! negatively regulates mesenchymal cell proliferation involved in ureter development creation_date: 2010-03-01T03:42:31Z [Term] id: GO:0072201 name: negative regulation of mesenchymal cell proliferation namespace: biological_process def: "Any process that decreases the frequency, rate or extent of mesenchymal cell proliferation. A mesenchymal cell is a cell that normally gives rise to other cells that are organized as three-dimensional masses, rather than sheets." [GOC:mtg_kidney_jan10] is_a: GO:0008285 ! negative regulation of cell population proliferation is_a: GO:0010464 ! regulation of mesenchymal cell proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0010463 ! negatively regulates mesenchymal cell proliferation relationship: RO:0002212 GO:0010463 ! negatively regulates mesenchymal cell proliferation property_value: RO:0002161 NCBITaxon:4751 creation_date: 2010-03-01T03:43:29Z [Term] id: GO:0072202 name: cell differentiation involved in metanephros development namespace: biological_process def: "The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the cells of the metanephros as it progresses from its formation to the mature state." [GOC:mah, GOC:mtg_kidney_jan10] is_a: GO:0061005 ! cell differentiation involved in kidney development intersection_of: GO:0030154 ! cell differentiation intersection_of: BFO:0000050 GO:0001656 ! part of metanephros development relationship: BFO:0000050 GO:0001656 ! part of metanephros development creation_date: 2010-03-18T10:40:14Z [Term] id: GO:0072203 name: cell proliferation involved in metanephros development namespace: biological_process def: "The multiplication or reproduction of cells, resulting in the expansion of the population in the metanephros." [GOC:mtg_kidney_jan10] is_a: GO:0072111 ! cell proliferation involved in kidney development intersection_of: GO:0008283 ! cell population proliferation intersection_of: BFO:0000050 GO:0001656 ! part of metanephros development relationship: BFO:0000050 GO:0001656 ! part of metanephros development creation_date: 2010-03-18T10:42:27Z [Term] id: GO:0072204 name: cell-cell signaling involved in metanephros development namespace: biological_process def: "Any process that mediates the transfer of information from one cell to another and contributes to the progression of the metanephros over time, from its formation to the mature organ." [GOC:mtg_kidney_jan10] synonym: "cell-cell signalling involved in metanephros development" EXACT [GOC:mah] is_a: GO:0060995 ! cell-cell signaling involved in kidney development intersection_of: GO:0007267 ! cell-cell signaling intersection_of: BFO:0000050 GO:0001656 ! part of metanephros development relationship: BFO:0000050 GO:0001656 ! part of metanephros development creation_date: 2010-03-18T10:54:36Z [Term] id: GO:0072205 name: metanephric collecting duct development namespace: biological_process def: "The process whose specific outcome is the progression of a collecting duct in the metanephros over time, from its formation to the mature structure. The collecting duct responds to vasopressin and aldosterone to regulate water, electrolyte and acid-base balance. The collecting duct is the final common path through which urine flows before entering the ureter and then emptying into the bladder." [GOC:mtg_kidney_jan10] is_a: GO:0072044 ! collecting duct development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0004737 ! results in development of metanephric collecting duct relationship: BFO:0000050 GO:0001656 ! part of metanephros development relationship: RO:0002296 UBERON:0004737 ! results in development of metanephric collecting duct creation_date: 2010-03-18T11:15:37Z [Term] id: GO:0072206 name: metanephric juxtaglomerular apparatus development namespace: biological_process def: "The process whose specific outcome is the progression of the juxtaglomerular apparatus in the metanephros over time, from its formation to the mature structure. The juxtaglomerular apparatus is an anatomical structure which consists of juxtaglomerular cells, extraglomerular mesangial cells and the macula densa. The juxtaglomerular apparatus lies adjacent to the glomerulus and regulates kidney function by maintaining the blood flow to the kidney and the filtration rate." [GOC:mtg_kidney_jan10] is_a: GO:0072051 ! juxtaglomerular apparatus development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0004738 ! results in development of metanephric juxtaglomerular apparatus relationship: BFO:0000050 GO:0001656 ! part of metanephros development relationship: RO:0002296 UBERON:0004738 ! results in development of metanephric juxtaglomerular apparatus creation_date: 2010-03-18T11:17:47Z [Term] id: GO:0072207 name: metanephric epithelium development namespace: biological_process def: "The process whose specific outcome is the progression of an epithelium in the metanephros over time, from its formation to the mature structure. An epithelium is a tissue that covers the internal or external surfaces of an anatomical structure." [GOC:mtg_kidney_jan10] is_a: GO:0072073 ! kidney epithelium development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0005108 ! results in development of metanephric epithelium relationship: BFO:0000050 GO:0001656 ! part of metanephros development relationship: RO:0002296 UBERON:0005108 ! results in development of metanephric epithelium creation_date: 2010-03-18T11:50:37Z [Term] id: GO:0072208 name: metanephric smooth muscle tissue development namespace: biological_process def: "The process whose specific outcome is the progression of smooth muscle in the metanephros over time, from its formation to the mature structure." [GOC:mtg_kidney_jan10] is_a: GO:0072194 ! kidney smooth muscle tissue development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0005109 ! results in development of metanephric smooth muscle tissue relationship: BFO:0000050 GO:0001656 ! part of metanephros development relationship: RO:0002296 UBERON:0005109 ! results in development of metanephric smooth muscle tissue creation_date: 2010-03-18T11:51:59Z [Term] id: GO:0072210 name: metanephric nephron development namespace: biological_process def: "The process whose specific outcome is the progression of a nephron in the metanephros over time, from its formation to the mature structure. A nephron is the functional unit of the kidney." [GOC:mtg_kidney_jan10] xref: Reactome:R-HSA-9831926 "Nephron development" is_a: GO:0072006 ! nephron development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0005110 ! results in development of metanephric nephron relationship: BFO:0000050 GO:0001656 ! part of metanephros development relationship: RO:0002296 UBERON:0005110 ! results in development of metanephric nephron creation_date: 2010-03-18T12:52:57Z [Term] id: GO:0072211 name: metanephric pyramids development namespace: biological_process def: "The process whose specific outcome is the progression of the metanephric pyramids over time, from their formation to the mature structures. Metanephric pyramids are the conical masses that constitute the renal medulla in a metanephros; they contain the loops of Henle and the medullary collecting ducts." [GOC:mtg_kidney_jan10] synonym: "metanephric kidney pyramid development" EXACT [GOC:mah] synonym: "metanephric pyramid development" EXACT [GOC:mah] synonym: "metanephric renal medulla development" EXACT [GOC:mah] synonym: "metanephric renal pyramid development" EXACT [GOC:mah] is_a: GO:0072056 ! pyramid development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0005111 ! results in development of metanephric pyramid relationship: BFO:0000050 GO:0001656 ! part of metanephros development relationship: RO:0002296 UBERON:0005111 ! results in development of metanephric pyramid creation_date: 2010-03-18T01:04:51Z [Term] id: GO:0072213 name: metanephric capsule development namespace: biological_process def: "The process whose specific outcome is the progression of the metanephric capsule over time, from its formation to the mature structure. The metanephric capsule is the tough fibrous layer surrounding the metanephros, covered in a thick layer of perinephric adipose tissue. It provides some protection from trauma and damage." [GOC:mtg_kidney_jan10] is_a: GO:0072127 ! renal capsule development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0005137 ! results in development of metanephric capsule relationship: BFO:0000050 GO:0001656 ! part of metanephros development relationship: RO:0002296 UBERON:0005137 ! results in development of metanephric capsule creation_date: 2010-03-18T01:25:19Z [Term] id: GO:0072214 name: metanephric cortex development namespace: biological_process def: "The process whose specific outcome is the progression of the metanephric cortex over time, from its formation to the mature structure. The metanephric cortex is the outer region of the metanephros." [GOC:mtg_kidney_jan10] is_a: GO:0060485 ! mesenchyme development is_a: GO:0072055 ! renal cortex development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0005113 ! results in development of metanephric cortex mesenchyme relationship: BFO:0000050 GO:0001656 ! part of metanephros development relationship: RO:0002296 UBERON:0005113 ! results in development of metanephric cortex mesenchyme creation_date: 2010-03-18T01:29:49Z [Term] id: GO:0072215 name: regulation of metanephros development namespace: biological_process def: "Any process that modulates the rate, frequency or extent of metanephros development. Metanephros development is the process whose specific outcome is the progression of the metanephros over time, from its formation to the mature structure. The metanephros is an endocrine and metabolic organ that filters the blood and excretes the end products of body metabolism in the form of urine." [GOC:mtg_kidney_jan10] is_a: GO:0090183 ! regulation of kidney development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0001656 ! regulates metanephros development relationship: RO:0002211 GO:0001656 ! regulates metanephros development [Term] id: GO:0072216 name: positive regulation of metanephros development namespace: biological_process def: "Any process that increases the rate, frequency or extent of metanephros development. Metanephros development is the process whose specific outcome is the progression of the metanephros over time, from its formation to the mature structure. The metanephros is an organ that filters the blood and excretes the end products of body metabolism in the form of urine." [GOC:mtg_kidney_jan10] is_a: GO:0072215 ! regulation of metanephros development is_a: GO:0090184 ! positive regulation of kidney development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0001656 ! positively regulates metanephros development relationship: RO:0002213 GO:0001656 ! positively regulates metanephros development creation_date: 2010-03-18T01:40:12Z [Term] id: GO:0072217 name: negative regulation of metanephros development namespace: biological_process def: "Any process that decreases the rate, frequency or extent of metanephros development. Metanephros development is the process whose specific outcome is the progression of the metanephros over time, from its formation to the mature structure. The metanephros is an organ that filters the blood and excretes the end products of body metabolism in the form of urine." [GOC:mtg_kidney_jan10] is_a: GO:0072215 ! regulation of metanephros development is_a: GO:0090185 ! negative regulation of kidney development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0001656 ! negatively regulates metanephros development relationship: RO:0002212 GO:0001656 ! negatively regulates metanephros development creation_date: 2010-03-18T01:45:48Z [Term] id: GO:0072218 name: metanephric ascending thin limb development namespace: biological_process def: "The process whose specific outcome is the progression of a metanephric ascending thin limb over time, from its formation to the mature structure. The metanephric ascending thin limb is a segment of a nephron tubule in the metanephros lying in the inner medulla that is permeable to ions but not to water and has a simple epithelium; active transepithelial solute transport is absent." [GOC:mtg_kidney_jan10] is_a: GO:0072021 ! ascending thin limb development is_a: GO:0072234 ! metanephric nephron tubule development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0005114 ! results in development of metanephric ascending thin limb relationship: BFO:0000050 GO:0072236 ! part of metanephric loop of Henle development relationship: RO:0002296 UBERON:0005114 ! results in development of metanephric ascending thin limb creation_date: 2010-03-18T03:34:42Z [Term] id: GO:0072219 name: metanephric cortical collecting duct development namespace: biological_process def: "The process whose specific outcome is the progression of the metanephric cortical collecting duct over time, from its formation to the mature structure. The metanephric cortical collecting duct is the portion of the metanephric collecting duct that resides in the renal cortex." [GOC:mtg_kidney_jan10] is_a: GO:0072059 ! cortical collecting duct development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0005115 ! results in development of metanephric cortical collecting duct relationship: RO:0002296 UBERON:0005115 ! results in development of metanephric cortical collecting duct creation_date: 2010-03-18T03:34:52Z [Term] id: GO:0072220 name: metanephric descending thin limb development namespace: biological_process def: "The process whose specific outcome is the progression of the metanephric descending thin limb over time, from its formation to the mature structure. The metanephric descending thin limb is a part of the metanephric loop of Henle situated just after the proximal straight tubule (S3). It extends to the tip of the metanephric loop of Henle." [GOC:mtg_kidney_jan10] is_a: GO:0072022 ! descending thin limb development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0005116 ! results in development of metanephric descending thin limb relationship: BFO:0000050 GO:0072236 ! part of metanephric loop of Henle development relationship: RO:0002296 UBERON:0005116 ! results in development of metanephric descending thin limb creation_date: 2010-03-18T03:35:05Z [Term] id: GO:0072221 name: metanephric distal convoluted tubule development namespace: biological_process def: "The process whose specific outcome is the progression of the metanephric distal convoluted tubule over time, from its formation to the mature structure. The metanephric distal convoluted tubule is the first segment of the metanephric nephron lying just downstream from the loop of Henle, immediately after the macula densa. Among other functions, in humans it is responsible for the reabsorption of about 5% of filtered sodium via the thiazide-sensitive Na-Cl symporter." [GOC:mtg_kidney_jan10] is_a: GO:0072025 ! distal convoluted tubule development is_a: GO:0072234 ! metanephric nephron tubule development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0005117 ! results in development of metanephric distal convoluted tubule relationship: BFO:0000050 GO:0072235 ! part of metanephric distal tubule development relationship: RO:0002296 UBERON:0005117 ! results in development of metanephric distal convoluted tubule creation_date: 2010-03-18T03:35:27Z [Term] id: GO:0072222 name: metanephric early distal convoluted tubule development namespace: biological_process def: "The process whose specific outcome is the progression of the metanephric early distal convoluted tubule over time, from its formation to the mature structure. The metanephric early distal convoluted tubule contains metanephric DCT cells and is vasopressin-insensitive." [GOC:mtg_kidney_jan10] is_a: GO:0072067 ! early distal convoluted tubule development is_a: GO:0072243 ! metanephric nephron epithelium development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0005118 ! results in development of metanephric early distal convoluted tubule relationship: BFO:0000050 GO:0072221 ! part of metanephric distal convoluted tubule development relationship: RO:0002296 UBERON:0005118 ! results in development of metanephric early distal convoluted tubule creation_date: 2010-03-18T03:35:46Z [Term] id: GO:0072223 name: metanephric glomerular mesangium development namespace: biological_process def: "The process whose specific outcome is the progression of the metanephric glomerular mesangium over time, from its formation to the mature structure. The metanephric glomerular mesangium is the thin membrane connective tissue composed of mesangial cells in the metanephros, which helps to support the capillary loops in a renal glomerulus." [GOC:mtg_kidney_jan10] is_a: GO:0072109 ! glomerular mesangium development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0005119 ! results in development of metanephric glomerular mesangium relationship: BFO:0000050 GO:0072239 ! part of metanephric glomerulus vasculature development relationship: RO:0002296 UBERON:0005119 ! results in development of metanephric glomerular mesangium creation_date: 2010-03-18T03:35:56Z [Term] id: GO:0072224 name: metanephric glomerulus development namespace: biological_process def: "The progression of the metanephric glomerulus over time from its initial formation until its mature state. The metanephric glomerulus is a capillary tuft which forms a close network with the visceral epithelium (podocytes) and the mesangium to form the filtration barrier and is surrounded by Bowman's capsule in nephrons of the mature vertebrate kidney, or metanephros." [GOC:mah] synonym: "metanephric glomerular development" EXACT [GOC:mtg_kidney_jan10] is_a: GO:0032835 ! glomerulus development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0004736 ! results in development of metanephric glomerulus relationship: BFO:0000050 GO:0072210 ! part of metanephric nephron development relationship: RO:0002296 UBERON:0004736 ! results in development of metanephric glomerulus creation_date: 2010-03-18T03:36:20Z [Term] id: GO:0072225 name: metanephric late distal convoluted tubule development namespace: biological_process def: "The process whose specific outcome is the progression of the metanephric late distal convoluted tubule over time, from its formation to the mature structure. The metanephric late distal convoluted tubule contains metanephric DCT cells and intercalated (IC) alpha and beta cells and is vasopressin-sensitive." [GOC:mtg_kidney_jan10] is_a: GO:0072068 ! late distal convoluted tubule development is_a: GO:0072243 ! metanephric nephron epithelium development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0005120 ! results in development of metanephric late distal convoluted tubule relationship: BFO:0000050 GO:0072221 ! part of metanephric distal convoluted tubule development relationship: RO:0002296 UBERON:0005120 ! results in development of metanephric late distal convoluted tubule creation_date: 2010-03-18T03:37:04Z [Term] id: GO:0072227 name: metanephric macula densa development namespace: biological_process def: "The process whose specific outcome is the progression of the metanephric macula densa over time, from its formation to the mature structure. The metanephric macula densa is an area of specialized cells in the distal tubule of the metanephros that makes contact with the vascular pole of the glomerulus." [GOC:mtg_kidney_jan10] is_a: GO:0072024 ! macula densa development is_a: GO:0072243 ! metanephric nephron epithelium development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0005122 ! results in development of metanephric macula densa relationship: BFO:0000050 GO:0072206 ! part of metanephric juxtaglomerular apparatus development relationship: RO:0002296 UBERON:0005122 ! results in development of metanephric macula densa creation_date: 2010-03-18T03:37:26Z [Term] id: GO:0072229 name: metanephric proximal convoluted tubule development namespace: biological_process def: "The process whose specific outcome is the progression of the metanephric proximal convoluted tubule over time, from its formation to the mature structure. The metanephric proximal convoluted tubule is the most proximal portion of the metanephric proximal tubule and extends from the metanephric glomerular capsule to the metanephric proximal straight tubule." [GOC:mtg_kidney_jan10] is_a: GO:0072019 ! proximal convoluted tubule development is_a: GO:0072234 ! metanephric nephron tubule development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0005124 ! results in development of metanephric proximal convoluted tubule relationship: BFO:0000050 GO:0072237 ! part of metanephric proximal tubule development relationship: RO:0002296 UBERON:0005124 ! results in development of metanephric proximal convoluted tubule creation_date: 2010-03-18T03:37:56Z [Term] id: GO:0072230 name: metanephric proximal straight tubule development namespace: biological_process def: "The process whose specific outcome is the progression of the metanephric proximal straight tubule over time, from its formation to the mature structure. The metanephric proximal straight tubule is the part of the metanephric descending limb that extends from the metanephric proximal convoluted tubule to the metanephric descending thin tubule." [GOC:mtg_kidney_jan10] synonym: "metanephric S3 development" EXACT [GOC:mtg_kidney_jan10] is_a: GO:0072020 ! proximal straight tubule development is_a: GO:0072234 ! metanephric nephron tubule development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0005125 ! results in development of metanephric proximal straight tubule relationship: BFO:0000050 GO:0072237 ! part of metanephric proximal tubule development relationship: RO:0002296 UBERON:0005125 ! results in development of metanephric proximal straight tubule creation_date: 2010-03-18T03:38:53Z [Term] id: GO:0072231 name: metanephric proximal convoluted tubule segment 1 development namespace: biological_process def: "The process whose specific outcome is the progression of the S1 portion of the metanephric proximal convoluted tubule over time, from its formation to the mature structure. The S1 portion is the initial portion of the metanephric proximal convoluted tubule and is responsible for avid reabsorption of water and solutes." [GOC:bf, GOC:mtg_kidney_jan10] synonym: "metanephric S1 development" EXACT [GOC:mtg_kidney_jan10] is_a: GO:0072031 ! proximal convoluted tubule segment 1 development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0005126 ! results in development of metanephric S1 relationship: BFO:0000050 GO:0072229 ! part of metanephric proximal convoluted tubule development relationship: RO:0002296 UBERON:0005126 ! results in development of metanephric S1 creation_date: 2010-03-18T03:39:10Z [Term] id: GO:0072233 name: metanephric thick ascending limb development namespace: biological_process def: "The process whose specific outcome is the progression of the metanephric thick ascending limb over time, from its formation to the mature structure. The metanephric thick ascending limb is the last part of the metanephric loop of Henle. Its thick, mitochondria-rich epithelium characterizes the outer medulla, and is responsible for very avid active salt transport. At the macula densa, the thick ascending limb connects to the distal convoluted tubule." [GOC:mtg_kidney_jan10] synonym: "metanephric TAL development" EXACT [GOC:mtg_kidney_jan10] is_a: GO:0072023 ! thick ascending limb development is_a: GO:0072234 ! metanephric nephron tubule development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0005127 ! results in development of metanephric thick ascending limb relationship: BFO:0000050 GO:0072235 ! part of metanephric distal tubule development relationship: RO:0002296 UBERON:0005127 ! results in development of metanephric thick ascending limb creation_date: 2010-03-18T03:39:36Z [Term] id: GO:0072234 name: metanephric nephron tubule development namespace: biological_process def: "The progression of a metanephric nephron tubule over time, from its initial formation to the mature structure. A metanephric nephron tubule is an epithelial tube that is part of the metanephric nephron, the functional part of the metanephros." [GOC:mtg_kidney_jan10] is_a: GO:0072080 ! nephron tubule development is_a: GO:0072170 ! metanephric tubule development is_a: GO:0072243 ! metanephric nephron epithelium development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0005146 ! results in development of metanephric nephron tubule relationship: RO:0002296 UBERON:0005146 ! results in development of metanephric nephron tubule creation_date: 2010-03-18T03:41:23Z [Term] id: GO:0072235 name: metanephric distal tubule development namespace: biological_process def: "The process whose specific outcome is the progression of the metanephric distal tubule over time, from its formation to the mature structure. The metanephric distal tubule is a metanephric nephron tubule that begins at the metanephric macula densa and extends to the metanephric connecting tubule." [GOC:mtg_kidney_jan10] is_a: GO:0072017 ! distal tubule development is_a: GO:0072234 ! metanephric nephron tubule development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0005129 ! results in development of metanephric distal tubule relationship: RO:0002296 UBERON:0005129 ! results in development of metanephric distal tubule creation_date: 2010-03-18T03:45:37Z [Term] id: GO:0072236 name: metanephric loop of Henle development namespace: biological_process def: "The process whose specific outcome is the progression of the metanephric loop of Henle over time, from its formation to the mature structure. The metanephric loop of Henle is a metanephric nephron tubule that connects the proximal convoluted tubule to the distal convoluted tubule in the metanephros." [GOC:mtg_kidney_jan10] synonym: "metanephric intermediate tubule development" EXACT [] is_a: GO:0072070 ! loop of Henle development is_a: GO:0072234 ! metanephric nephron tubule development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0005130 ! results in development of metanephric loop of Henle relationship: RO:0002296 UBERON:0005130 ! results in development of metanephric loop of Henle creation_date: 2010-03-18T03:46:18Z [Term] id: GO:0072237 name: metanephric proximal tubule development namespace: biological_process def: "The process whose specific outcome is the progression of the metanephric proximal tubule over time, from its formation to the mature structure. The metanephric proximal tubule is a metanephric nephron tubule that connects Bowman's capsule to the descending thin limb of the loop of Henle in the metanephros. It has a brush border epithelial morphology." [GOC:mtg_kidney_jan10] is_a: GO:0072014 ! proximal tubule development is_a: GO:0072234 ! metanephric nephron tubule development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0005151 ! results in development of metanephric proximal tubule relationship: RO:0002296 UBERON:0005151 ! results in development of metanephric proximal tubule creation_date: 2010-03-18T03:46:54Z [Term] id: GO:0072238 name: metanephric long nephron development namespace: biological_process def: "The process whose specific outcome is the progression of a metanephric long nephron over time, from its formation to the mature structure. Long nephrons are associated with juxtamedullary glomeruli and extend into the inner medulla in the metanephros." [GOC:mtg_kidney_jan10] synonym: "metanephric juxtamedullary nephron development" RELATED [GOC:mtg_kidney_jan10] is_a: GO:0072029 ! long nephron development is_a: GO:0072210 ! metanephric nephron development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0005132 ! results in development of metanephric long nephron relationship: RO:0002296 UBERON:0005132 ! results in development of metanephric long nephron creation_date: 2010-03-18T03:48:23Z [Term] id: GO:0072239 name: metanephric glomerulus vasculature development namespace: biological_process def: "The biological process whose specific outcome is the progression of a metanephric glomerulus vasculature from an initial condition to its mature state. This process begins with the formation of the metanephric glomerulus vasculature and ends with the mature structure. The metanephric glomerulus vasculature is composed of the tubule structures that carry blood or lymph in the metanephric glomerulus." [GOC:mtg_kidney_jan10] synonym: "glomerulus capillary development" RELATED [GOC:mtg_kidney_jan10] is_a: GO:0072012 ! glomerulus vasculature development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0005133 ! results in development of metanephric glomerulus vasculature relationship: BFO:0000050 GO:0072224 ! part of metanephric glomerulus development relationship: RO:0002296 UBERON:0005133 ! results in development of metanephric glomerulus vasculature creation_date: 2010-03-18T03:50:29Z [Term] id: GO:0072243 name: metanephric nephron epithelium development namespace: biological_process def: "The process whose specific outcome is the progression of the metanephric nephron epithelium over time, from its formation to the mature structure. An epithelium is a tissue that covers the internal or external surfaces of an anatomical structure. The metanephric nephron epithelium is a tissue that covers the surface of a nephron in the metanephros." [GOC:mtg_kidney_jan10] is_a: GO:0072009 ! nephron epithelium development is_a: GO:0072207 ! metanephric epithelium development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0005134 ! results in development of metanephric nephron epithelium relationship: RO:0002296 UBERON:0005134 ! results in development of metanephric nephron epithelium creation_date: 2010-03-19T03:29:49Z [Term] id: GO:0072244 name: metanephric glomerular epithelium development namespace: biological_process def: "The process whose specific outcome is the progression of the metanephric glomerular epithelium over time, from its formation to the mature structure. The metanephric glomerular epithelium is an epithelial tissue that covers the outer surfaces of the glomerulus in the metanephros. The metanephric glomerular epithelium consists of both parietal and visceral epithelium. Metanephric glomerular parietal epithelial cells are specialized epithelial cells that form tight junctions as a barrier to protein transport. A metanephric glomerular visceral epithelial cell is a specialized epithelial cell that contains 'feet' that interdigitate with the 'feet' of other glomerular epithelial cells in the metanephros." [GOC:mtg_kidney_jan10] is_a: GO:0072010 ! glomerular epithelium development is_a: GO:0072243 ! metanephric nephron epithelium development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0005135 ! results in development of metanephric glomerular epithelium relationship: BFO:0000050 GO:0072224 ! part of metanephric glomerulus development relationship: RO:0002296 UBERON:0005135 ! results in development of metanephric glomerular epithelium creation_date: 2010-03-19T03:38:47Z [Term] id: GO:0072248 name: metanephric podocyte differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a metanephric glomerular visceral epithelial cell. A metanephric glomerular visceral epithelial cell is a specialized epithelial cell that contains 'feet' that interdigitate with the 'feet' of other glomerular epithelial cells in the metanephros." [GOC:mtg_kidney_jan10] synonym: "metanephric glomerular visceral epithelial cell differentiation" EXACT [] is_a: GO:0072112 ! podocyte differentiation is_a: GO:0072312 ! metanephric glomerular epithelial cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0002525 ! results in acquisition of features of metanephric podocyte relationship: RO:0002315 CL:0002525 ! results in acquisition of features of metanephric podocyte property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/23000" xsd:anyURI creation_date: 2010-03-19T03:44:57Z [Term] id: GO:0072249 name: metanephric podocyte development namespace: biological_process def: "The process whose specific outcome is the progression of a metanephric glomerular visceral epithelial cell over time, from its formation to the mature structure. A metanephric glomerular visceral epithelial cell is a specialized epithelial cell that contains 'feet' that interdigitate with the 'feet' of other glomerular epithelial cells in the metanephros." [GOC:mtg_kidney_jan10] synonym: "metanephric glomerular visceral epithelial cell development" EXACT [] is_a: GO:0072015 ! podocyte development is_a: GO:0072313 ! metanephric glomerular epithelial cell development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 CL:0002525 ! results in development of metanephric podocyte relationship: BFO:0000050 GO:0072248 ! part of metanephric podocyte differentiation relationship: RO:0002296 CL:0002525 ! results in development of metanephric podocyte property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/23000" xsd:anyURI creation_date: 2010-03-19T03:46:26Z [Term] id: GO:0072257 name: metanephric nephron tubule epithelial cell differentiation namespace: biological_process def: "The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the cells of the metanephric nephron tubule as it progresses from its formation to the mature state." [GOC:mtg_kidney_jan10] is_a: GO:0072160 ! nephron tubule epithelial cell differentiation is_a: GO:0072202 ! cell differentiation involved in metanephros development intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:1000123 ! results in acquisition of features of metanephric nephron tubule epithelial cell relationship: BFO:0000050 GO:0072234 ! part of metanephric nephron tubule development relationship: RO:0002315 CL:1000123 ! results in acquisition of features of metanephric nephron tubule epithelial cell creation_date: 2010-03-19T04:11:02Z [Term] id: GO:0072264 name: metanephric glomerular endothelium development namespace: biological_process def: "The process whose specific outcome is the progression of the metanephric glomerular endothelium over time, from its formation to the mature structure. The metanephric glomerular endothelium is an epithelial tissue that covers the internal surfaces of the glomerulus of the metanephros." [GOC:mtg_kidney_jan10] is_a: GO:0072011 ! glomerular endothelium development is_a: GO:0072244 ! metanephric glomerular epithelium development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0005136 ! results in development of metanephric glomerular endothelium relationship: BFO:0000050 GO:0072239 ! part of metanephric glomerulus vasculature development relationship: RO:0002296 UBERON:0005136 ! results in development of metanephric glomerular endothelium creation_date: 2010-03-30T02:42:26Z [Term] id: GO:0072265 name: metanephric capsule morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the metanephric capsule are generated and organized. The metanephric capsule is the tough fibrous layer surrounding the metanephros, covered in a thick layer of perinephric adipose tissue. It provides some protection from trauma and damage." [GOC:mtg_kidney_jan10] is_a: GO:0072128 ! renal capsule morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0005137 ! results in morphogenesis of metanephric capsule relationship: BFO:0000050 GO:0072213 ! part of metanephric capsule development relationship: RO:0002298 UBERON:0005137 ! results in morphogenesis of metanephric capsule creation_date: 2010-03-30T02:54:49Z [Term] id: GO:0072266 name: metanephric capsule formation namespace: biological_process def: "The developmental process pertaining to the initial formation of a metanephric capsule from unspecified parts. The metanephric capsule is the tough fibrous layer surrounding the metanephros, covered in a thick layer of perinephric adipose tissue. It provides some protection from trauma and damage." [GOC:mtg_kidney_jan10] is_a: GO:0072129 ! renal capsule formation intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0005137 ! results in formation of anatomical entity metanephric capsule relationship: BFO:0000050 GO:0072265 ! part of metanephric capsule morphogenesis relationship: RO:0002297 UBERON:0005137 ! results in formation of anatomical entity metanephric capsule creation_date: 2010-03-30T02:56:35Z [Term] id: GO:0072268 name: pattern specification involved in metanephros development namespace: biological_process def: "Any developmental process that results in the creation of defined areas or spaces within the metanephros to which cells respond and eventually are instructed to differentiate." [GOC:mtg_kidney_jan10] synonym: "metanephros pattern formation" RELATED [GOC:mtg_kidney_jan10] synonym: "metanephros pattern specification" EXACT [GOC:mtg_kidney_jan10] synonym: "pattern formation involved in metanephros development" RELATED [GOC:mtg_kidney_jan10] is_a: GO:0061004 ! pattern specification involved in kidney development intersection_of: GO:0007389 ! pattern specification process intersection_of: BFO:0000050 GO:0001656 ! part of metanephros development relationship: BFO:0000050 GO:0001656 ! part of metanephros development creation_date: 2010-03-30T03:06:30Z [Term] id: GO:0072269 name: metanephric long descending thin limb development namespace: biological_process def: "The process whose specific outcome is the progression of the metanephric long descending thin limb over time, from its formation to the mature structure. The metanephric long descending thin limb is the descending thin limb of a long nephron in the metanephros that has a squamous epithelial morphology. The long descending limb starts in the inner stripe of the outer medulla and extends into the inner medulla." [GOC:mtg_kidney_jan10] is_a: GO:0072064 ! long descending thin limb development is_a: GO:0072243 ! metanephric nephron epithelium development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0005139 ! results in development of metanephric long descending thin limb relationship: BFO:0000050 GO:0072238 ! part of metanephric long nephron development relationship: RO:0002296 UBERON:0005139 ! results in development of metanephric long descending thin limb creation_date: 2010-03-30T03:12:05Z [Term] id: GO:0072270 name: metanephric short nephron development namespace: biological_process def: "The process whose specific outcome is the progression of a short nephron in the metanephros over time, from its formation to the mature structure. Short nephrons are associated with mid-cortical and superficial glomeruli, are situated entirely in the outer medulla, and have no thin ascending limb." [GOC:mtg_kidney_jan10] is_a: GO:0072030 ! short nephron development is_a: GO:0072210 ! metanephric nephron development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0005140 ! results in development of metanephric short nephron relationship: RO:0002296 UBERON:0005140 ! results in development of metanephric short nephron creation_date: 2010-03-30T03:15:18Z [Term] id: GO:0072271 name: metanephric short descending thin limb development namespace: biological_process def: "The process whose specific outcome is the progression of the metanephric short descending thin limb over time, from its formation to the mature structure. The metanephric short descending thin limb is the descending thin limb of a short nephron in the metanephros that has a squamous epithelial morphology." [GOC:mtg_kidney_jan10] is_a: GO:0072063 ! short descending thin limb development is_a: GO:0072243 ! metanephric nephron epithelium development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0005141 ! results in development of metanephric short descending thin limb relationship: BFO:0000050 GO:0072270 ! part of metanephric short nephron development relationship: RO:0002296 UBERON:0005141 ! results in development of metanephric short descending thin limb creation_date: 2010-03-30T03:16:25Z [Term] id: GO:0072273 name: metanephric nephron morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the metanephric nephron are generated and organized. A metanephric nephron is the functional unit of the metanephros." [GOC:mtg_kidney_jan10] is_a: GO:0072028 ! nephron morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0005110 ! results in morphogenesis of metanephric nephron relationship: BFO:0000050 GO:0003338 ! part of metanephros morphogenesis relationship: BFO:0000050 GO:0072210 ! part of metanephric nephron development relationship: RO:0002298 UBERON:0005110 ! results in morphogenesis of metanephric nephron creation_date: 2010-03-30T03:33:19Z [Term] id: GO:0072275 name: metanephric glomerulus morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the metanephric glomerulus are generated and organized. The metanephric glomerulus is a capillary tuft surrounded by Bowman's capsule in nephrons of the vertebrate kidney, or metanephros." [GOC:mtg_kidney_jan10] is_a: GO:0072102 ! glomerulus morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0004736 ! results in morphogenesis of metanephric glomerulus relationship: BFO:0000050 GO:0072224 ! part of metanephric glomerulus development relationship: RO:0002298 UBERON:0004736 ! results in morphogenesis of metanephric glomerulus creation_date: 2010-04-01T02:46:58Z [Term] id: GO:0072276 name: metanephric glomerulus vasculature morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the metanephric glomerulus vasculature are generated and organized. The metanephric glomerulus vasculature is composed of the tubule structures that carry blood or lymph in the metanephric glomerulus." [GOC:mtg_kidney_jan10] is_a: GO:0072103 ! glomerulus vasculature morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0005133 ! results in morphogenesis of metanephric glomerulus vasculature relationship: BFO:0000050 GO:0072239 ! part of metanephric glomerulus vasculature development relationship: BFO:0000050 GO:0072275 ! part of metanephric glomerulus morphogenesis relationship: RO:0002298 UBERON:0005133 ! results in morphogenesis of metanephric glomerulus vasculature creation_date: 2010-04-01T02:47:32Z [Term] id: GO:0072277 name: metanephric glomerular capillary formation namespace: biological_process def: "The process that gives rise to a metanephric glomerular capillary. This process pertains to the initial formation of a structure from unspecified parts." [GOC:mtg_kidney_jan10] is_a: GO:0072104 ! glomerular capillary formation intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0005144 ! results in formation of anatomical entity metanephric glomerular capillary relationship: BFO:0000050 GO:0072276 ! part of metanephric glomerulus vasculature morphogenesis relationship: RO:0002297 UBERON:0005144 ! results in formation of anatomical entity metanephric glomerular capillary creation_date: 2010-04-01T02:47:56Z [Term] id: GO:0072278 name: metanephric comma-shaped body morphogenesis namespace: biological_process def: "The process in which the metanephric comma-shaped body is generated and organized. The metanephric comma-shaped body is the precursor structure to the metanephric S-shaped body that contributes to the morphogenesis of a nephron in the metanephros." [GOC:mtg_kidney_jan10] is_a: GO:0072049 ! comma-shaped body morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0005145 ! results in morphogenesis of metanephric comma-shaped body relationship: BFO:0000050 GO:0072273 ! part of metanephric nephron morphogenesis relationship: RO:0002298 UBERON:0005145 ! results in morphogenesis of metanephric comma-shaped body creation_date: 2010-04-01T03:14:42Z [Term] id: GO:0072281 name: mesenchymal stem cell differentiation involved in metanephric nephron morphogenesis namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a mesenchymal stem cell that contributes to the shaping of a nephronin the metanephros. A mesenchymal stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized mesenchymal cells." [GOC:mtg_kidney_jan10] is_a: GO:0061208 ! cell differentiation involved in mesonephros development is_a: GO:0072037 ! mesenchymal stem cell differentiation involved in nephron morphogenesis is_a: GO:0072202 ! cell differentiation involved in metanephros development intersection_of: GO:0072497 ! mesenchymal stem cell differentiation intersection_of: BFO:0000050 GO:0072273 ! part of metanephric nephron morphogenesis relationship: BFO:0000050 GO:0072273 ! part of metanephric nephron morphogenesis creation_date: 2010-04-01T03:22:06Z [Term] id: GO:0072282 name: metanephric nephron tubule morphogenesis namespace: biological_process def: "The process in which the anatomical structures of a metanephric nephron tubule are generated and organized. A metanephric nephron tubule is an epithelial tube that is part of the metanephric nephron, the functional part of the metanephros." [GOC:mtg_kidney_jan10] is_a: GO:0072078 ! nephron tubule morphogenesis is_a: GO:0072173 ! metanephric tubule morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0005146 ! results in morphogenesis of metanephric nephron tubule relationship: BFO:0000050 GO:0072234 ! part of metanephric nephron tubule development relationship: BFO:0000050 GO:0072273 ! part of metanephric nephron morphogenesis relationship: RO:0002298 UBERON:0005146 ! results in morphogenesis of metanephric nephron tubule creation_date: 2010-04-01T03:25:11Z [Term] id: GO:0072283 name: metanephric renal vesicle morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the metanephric renal vesicle are generated and organized. The renal vesicle is the primordial structure of the metanephric nephron epithelium, and is formed by the condensation of mesenchymal cells." [GOC:mtg_kidney_jan10] is_a: GO:0072077 ! renal vesicle morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0005147 ! results in morphogenesis of metanephric renal vesicle relationship: BFO:0000050 GO:0072273 ! part of metanephric nephron morphogenesis relationship: RO:0002298 UBERON:0005147 ! results in morphogenesis of metanephric renal vesicle creation_date: 2010-04-01T03:28:00Z [Term] id: GO:0072284 name: metanephric S-shaped body morphogenesis namespace: biological_process def: "The process in which the metanephric S-shaped body is generated and organized. The metanephric S-shaped body is the successor of the metanephric comma-shaped body that contributes to the morphogenesis of a nephron in the metanephros." [GOC:mtg_kidney_jan10] is_a: GO:0072050 ! S-shaped body morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0005148 ! results in morphogenesis of metanephric S-shaped body relationship: BFO:0000050 GO:0072273 ! part of metanephric nephron morphogenesis relationship: RO:0002298 UBERON:0005148 ! results in morphogenesis of metanephric S-shaped body creation_date: 2010-04-01T03:41:36Z [Term] id: GO:0072285 name: mesenchymal to epithelial transition involved in metanephric renal vesicle formation namespace: biological_process def: "A transition where a mesenchymal cell establishes apical/basolateral polarity,forms intercellular adhesive junctions, synthesizes basement membrane components and becomes an epithelial cell that will contribute to the shaping of the metanephric renal vesicle." [GOC:mtg_kidney_jan10] is_a: GO:0003337 ! mesenchymal to epithelial transition involved in metanephros morphogenesis is_a: GO:0072036 ! mesenchymal to epithelial transition involved in renal vesicle formation intersection_of: GO:0060231 ! mesenchymal to epithelial transition intersection_of: BFO:0000050 GO:0072093 ! part of metanephric renal vesicle formation relationship: BFO:0000050 GO:0072093 ! part of metanephric renal vesicle formation creation_date: 2010-04-01T03:43:31Z [Term] id: GO:0072286 name: metanephric connecting tubule development namespace: biological_process def: "The process whose specific outcome is the progression of the metanephric connecting tubule over time, from its formation to the mature structure. The metanephric connecting tubule is a tubular segment of the metanephric nephron; it connects the distal convoluted tubule to the collecting duct in the metanephros." [GOC:mtg_kidney_jan10] synonym: "metanephric connecting duct development" EXACT [GOC:mtg_kidney_jan10] is_a: GO:0072027 ! connecting tubule development is_a: GO:0072234 ! metanephric nephron tubule development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0005149 ! results in development of metanephric connecting tubule relationship: RO:0002296 UBERON:0005149 ! results in development of metanephric connecting tubule creation_date: 2010-04-09T03:30:09Z [Term] id: GO:0072287 name: metanephric distal tubule morphogenesis namespace: biological_process def: "The process in which the anatomical structures of a metanephric distal tubule are generated and organized. The metanephric distal tubule is a metanephric nephron tubule that begins at the macula densa and extends to the metanephric connecting tubule." [GOC:mtg_kidney_jan10] is_a: GO:0072156 ! distal tubule morphogenesis is_a: GO:0072282 ! metanephric nephron tubule morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0005129 ! results in morphogenesis of metanephric distal tubule relationship: BFO:0000050 GO:0072235 ! part of metanephric distal tubule development relationship: RO:0002298 UBERON:0005129 ! results in morphogenesis of metanephric distal tubule creation_date: 2010-04-09T03:41:47Z [Term] id: GO:0072288 name: metanephric proximal tubule morphogenesis namespace: biological_process def: "The process in which the anatomical structures of a metanephric proximal tubule are generated and organized. The metanephric proximal tubule is a metanephric nephron tubule that connects Bowman's capsule to the descending thin limb of the loop of Henle in the metanephros. It has a brush border epithelial morphology." [GOC:mtg_kidney_jan10] is_a: GO:0072158 ! proximal tubule morphogenesis is_a: GO:0072282 ! metanephric nephron tubule morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0005151 ! results in morphogenesis of metanephric proximal tubule relationship: BFO:0000050 GO:0072237 ! part of metanephric proximal tubule development relationship: RO:0002298 UBERON:0005151 ! results in morphogenesis of metanephric proximal tubule creation_date: 2010-04-09T03:42:03Z [Term] id: GO:0072289 name: metanephric nephron tubule formation namespace: biological_process def: "The developmental process pertaining to the initial formation of a metanephric nephron tubule from unspecified parts. A metanephric nephron tubule is an epithelial tube that is part of a nephron in the metanephros." [GOC:mtg_kidney_jan10] is_a: GO:0072079 ! nephron tubule formation is_a: GO:0072174 ! metanephric tubule formation intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0005146 ! results in formation of anatomical entity metanephric nephron tubule relationship: BFO:0000050 GO:0072282 ! part of metanephric nephron tubule morphogenesis relationship: RO:0002297 UBERON:0005146 ! results in formation of anatomical entity metanephric nephron tubule creation_date: 2010-04-09T03:47:44Z [Term] id: GO:0072290 name: epithelial cell migration involved in metanephric nephron tubule morphogenesis namespace: biological_process def: "The orderly movement of epithelial cells within a renal tubule that contributes to metanephric nephron tubule morphogenesis." [GOC:mtg_kidney_jan10] is_a: GO:0035788 ! cell migration involved in metanephros development is_a: GO:0072155 ! epithelial cell migration involved in nephron tubule morphogenesis intersection_of: GO:0010631 ! epithelial cell migration intersection_of: BFO:0000050 GO:0072282 ! part of metanephric nephron tubule morphogenesis relationship: BFO:0000050 GO:0072282 ! part of metanephric nephron tubule morphogenesis creation_date: 2010-04-09T03:52:29Z [Term] id: GO:0072291 name: epithelial cell migration involved in metanephric distal tubule morphogenesis namespace: biological_process def: "The orderly movement of epithelial cells within a renal tubule that contributes to metanephric distal tubule morphogenesis." [GOC:mtg_kidney_jan10] is_a: GO:0072157 ! epithelial cell migration involved in distal tubule morphogenesis is_a: GO:0072290 ! epithelial cell migration involved in metanephric nephron tubule morphogenesis intersection_of: GO:0010631 ! epithelial cell migration intersection_of: BFO:0000050 GO:0072287 ! part of metanephric distal tubule morphogenesis relationship: BFO:0000050 GO:0072287 ! part of metanephric distal tubule morphogenesis creation_date: 2010-04-09T03:53:37Z [Term] id: GO:0072292 name: epithelial cell migration involved in metanephric proximal tubule morphogenesis namespace: biological_process def: "The orderly movement of epithelial cells within a renal tubule that contributes to metanephric proximal tubule morphogenesis." [GOC:mtg_kidney_jan10] is_a: GO:0072159 ! epithelial cell migration involved in proximal tubule morphogenesis is_a: GO:0072290 ! epithelial cell migration involved in metanephric nephron tubule morphogenesis intersection_of: GO:0010631 ! epithelial cell migration intersection_of: BFO:0000050 GO:0072288 ! part of metanephric proximal tubule morphogenesis relationship: BFO:0000050 GO:0072288 ! part of metanephric proximal tubule morphogenesis creation_date: 2010-04-09T03:54:28Z [Term] id: GO:0072298 name: regulation of metanephric glomerulus development namespace: biological_process def: "Any process that modulates the rate, frequency or extent of metanephric glomerulus development, the progression of the metanephric glomerulus over time from its initial formation until its mature state. The metanephric glomerulus is a capillary tuft surrounded by Bowman's capsule in nephrons of the vertebrate kidney, or metanephros." [GOC:mtg_kidney_jan10] is_a: GO:0001656 ! metanephros development is_a: GO:0090192 ! regulation of glomerulus development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0072224 ! regulates metanephric glomerulus development relationship: RO:0002211 GO:0072224 ! regulates metanephric glomerulus development creation_date: 2010-04-09T05:03:14Z [Term] id: GO:0072299 name: negative regulation of metanephric glomerulus development namespace: biological_process def: "Any process that decreases the rate, frequency or extent of metanephric glomerulus development, the progression of the metanephric glomerulus over time from its initial formation until its mature state. The metanephric glomerulus is a capillary tuft surrounded by Bowman's capsule in nephrons of the vertebrate kidney, or metanephros." [GOC:mtg_kidney_jan10] is_a: GO:0072217 ! negative regulation of metanephros development is_a: GO:0072298 ! regulation of metanephric glomerulus development is_a: GO:0090194 ! negative regulation of glomerulus development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0072224 ! negatively regulates metanephric glomerulus development relationship: RO:0002212 GO:0072224 ! negatively regulates metanephric glomerulus development creation_date: 2010-04-09T05:03:41Z [Term] id: GO:0072300 name: positive regulation of metanephric glomerulus development namespace: biological_process def: "Any process that increases the rate, frequency or extent of metanephric glomerulus development, the progression of the metanephric glomerulus over time from its initial formation until its mature state. The metanephric glomerulus is a capillary tuft surrounded by Bowman's capsule in nephrons of the vertebrate kidney, or metanephros." [GOC:mtg_kidney_jan10] is_a: GO:0072216 ! positive regulation of metanephros development is_a: GO:0072298 ! regulation of metanephric glomerulus development is_a: GO:0090193 ! positive regulation of glomerulus development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0072224 ! positively regulates metanephric glomerulus development relationship: RO:0002213 GO:0072224 ! positively regulates metanephric glomerulus development creation_date: 2010-04-09T05:03:41Z [Term] id: GO:0072304 name: regulation of mesenchymal cell apoptotic process involved in metanephric nephron morphogenesis namespace: biological_process def: "Any process that modulates the occurrence or rate of mesenchymal stem cell death by apoptotic process that contributes to the shaping of the nephron in the metanephros." [GOC:mtg_apoptosis, GOC:mtg_kidney_jan10] synonym: "regulation of mesenchymal stem cell apoptosis involved in metanephric nephron morphogenesis" NARROW [] synonym: "regulation of mesenchymal stem cell apoptotic process involved in metanephric nephron morphogenesis" EXACT [] is_a: GO:0072039 ! regulation of mesenchymal cell apoptotic process involved in nephron morphogenesis is_a: GO:1900211 ! regulation of mesenchymal cell apoptotic process involved in metanephros development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:1901147 ! regulates mesenchymal cell apoptotic process involved in metanephric nephron morphogenesis relationship: RO:0002211 GO:0072309 ! regulates mesenchymal stem cell maintenance involved in metanephric nephron morphogenesis relationship: RO:0002211 GO:1901147 ! regulates mesenchymal cell apoptotic process involved in metanephric nephron morphogenesis creation_date: 2010-04-09T05:03:41Z [Term] id: GO:0072305 name: negative regulation of mesenchymal cell apoptotic process involved in metanephric nephron morphogenesis namespace: biological_process def: "Any process that reduces the occurrence or rate of mesenchymal stem cell death by apoptotic process that contributes to the shaping of the nephron in the metanephros." [GOC:mtg_apoptosis, GOC:mtg_kidney_jan10] synonym: "negative regulation of mesenchymal stem cell apoptosis involved in metanephric nephron morphogenesis" NARROW [] synonym: "negative regulation of mesenchymal stem cell apoptotic process involved in metanephric nephron morphogenesis" EXACT [] is_a: GO:0072040 ! negative regulation of mesenchymal cell apoptotic process involved in nephron morphogenesis is_a: GO:0072304 ! regulation of mesenchymal cell apoptotic process involved in metanephric nephron morphogenesis is_a: GO:1900212 ! negative regulation of mesenchymal cell apoptotic process involved in metanephros development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:1901147 ! negatively regulates mesenchymal cell apoptotic process involved in metanephric nephron morphogenesis relationship: RO:0002212 GO:0072309 ! negatively regulates mesenchymal stem cell maintenance involved in metanephric nephron morphogenesis relationship: RO:0002212 GO:1901147 ! negatively regulates mesenchymal cell apoptotic process involved in metanephric nephron morphogenesis creation_date: 2010-04-09T05:03:41Z [Term] id: GO:0072306 name: positive regulation of mesenchymal cell apoptotic process involved in metanephric nephron morphogenesis namespace: biological_process def: "Any process that increases the occurrence or rate of mesenchymal stem cell death by apoptotic process that contributes to the shaping of the nephron in the metanephros." [GOC:mtg_apoptosis, GOC:mtg_kidney_jan10] synonym: "positive regulation of mesenchymal stem cell apoptosis involved in metanephric nephron morphogenesis" NARROW [] synonym: "positive regulation of mesenchymal stem cell apoptotic process involved in metanephric nephron morphogenesis" EXACT [] is_a: GO:0072041 ! positive regulation of mesenchymal cell apoptotic process involved in nephron morphogenesis is_a: GO:0072304 ! regulation of mesenchymal cell apoptotic process involved in metanephric nephron morphogenesis is_a: GO:1900213 ! positive regulation of mesenchymal cell apoptotic process involved in metanephros development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:1901147 ! positively regulates mesenchymal cell apoptotic process involved in metanephric nephron morphogenesis relationship: RO:0002213 GO:0072309 ! positively regulates mesenchymal stem cell maintenance involved in metanephric nephron morphogenesis relationship: RO:0002213 GO:1901147 ! positively regulates mesenchymal cell apoptotic process involved in metanephric nephron morphogenesis creation_date: 2010-04-09T05:03:41Z [Term] id: GO:0072307 name: regulation of metanephric nephron tubule epithelial cell differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of metanephric nephron tubule epithelial cell differentiation." [GOC:mtg_kidney_jan10] is_a: GO:0072182 ! regulation of nephron tubule epithelial cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0072257 ! regulates metanephric nephron tubule epithelial cell differentiation relationship: RO:0002211 GO:0072257 ! regulates metanephric nephron tubule epithelial cell differentiation creation_date: 2010-04-09T05:03:41Z [Term] id: GO:0072308 name: negative regulation of metanephric nephron tubule epithelial cell differentiation namespace: biological_process def: "Any process that decreases the frequency, rate or extent of metanephric nephron tubule epithelial cell differentiation." [GOC:mtg_kidney_jan10] is_a: GO:0072183 ! negative regulation of nephron tubule epithelial cell differentiation is_a: GO:0072307 ! regulation of metanephric nephron tubule epithelial cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0072257 ! negatively regulates metanephric nephron tubule epithelial cell differentiation relationship: RO:0002212 GO:0072257 ! negatively regulates metanephric nephron tubule epithelial cell differentiation creation_date: 2010-04-09T05:03:41Z [Term] id: GO:0072309 name: mesenchymal stem cell maintenance involved in metanephric nephron morphogenesis namespace: biological_process def: "The process in which an organism retains a population of mesenchymal stem cells that contributes to the shaping of a nephron in the metanephros. A mesenchymal stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized mesenchymal cells." [GOC:mtg_kidney_jan10] is_a: GO:0072038 ! mesenchymal stem cell maintenance involved in nephron morphogenesis relationship: BFO:0000050 GO:0072273 ! part of metanephric nephron morphogenesis creation_date: 2010-04-09T05:03:41Z [Term] id: GO:0072310 name: glomerular epithelial cell development namespace: biological_process def: "The process whose specific outcome is the progression of a glomerular epithelial cell over time, from its formation to the mature structure. Glomerular epithelial cells are specialized epithelial cells that form part of the glomerulus; there are two types, glomerular parietal epithelial cells and glomerular visceral epithelial cells." [GOC:mtg_kidney_jan10] is_a: GO:0002064 ! epithelial cell development relationship: BFO:0000050 GO:0072311 ! part of glomerular epithelial cell differentiation creation_date: 2010-04-09T06:47:31Z [Term] id: GO:0072311 name: glomerular epithelial cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a glomerular epithelial cell. Glomerular epithelial cells are specialized epithelial cells that form part of the glomerulus; there are two types, glomerular parietal epithelial cells and glomerular visceral epithelial cells." [GOC:mtg_kidney_jan10] is_a: GO:0035850 ! epithelial cell differentiation involved in kidney development relationship: BFO:0000050 GO:0072010 ! part of glomerular epithelium development creation_date: 2010-04-09T06:49:21Z [Term] id: GO:0072312 name: metanephric glomerular epithelial cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a metanephric glomerular epithelial cell. Metanephric glomerular epithelial cells are specialized epithelial cells that form part of the metanephric glomerulus; there are two types, metanephric glomerular parietal epithelial cells and metanephric glomerular visceral epithelial cells." [GOC:mtg_kidney_jan10] is_a: GO:0072202 ! cell differentiation involved in metanephros development is_a: GO:0072311 ! glomerular epithelial cell differentiation relationship: BFO:0000050 GO:0072244 ! part of metanephric glomerular epithelium development creation_date: 2010-04-09T06:54:15Z [Term] id: GO:0072313 name: metanephric glomerular epithelial cell development namespace: biological_process def: "The process whose specific outcome is the progression of a metanephric glomerular epithelial cell over time, from its formation to the mature structure. Metanephric glomerular epithelial cells are specialized epithelial cells that form part of the metanephric glomerulus; there are two types, metanephric glomerular parietal epithelial cells and metanephric glomerular visceral epithelial cells." [GOC:mtg_kidney_jan10] is_a: GO:0072310 ! glomerular epithelial cell development relationship: BFO:0000050 GO:0072312 ! part of metanephric glomerular epithelial cell differentiation creation_date: 2010-04-09T06:57:26Z [Term] id: GO:0072329 name: monocarboxylic acid catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of monocarboxylic acids, any organic acid containing one carboxyl (-COOH) group." [GOC:mah] is_a: GO:0032787 ! monocarboxylic acid metabolic process is_a: GO:0046395 ! carboxylic acid catabolic process intersection_of: GO:0009056 ! catabolic process intersection_of: RO:0004009 CHEBI:35757 ! has primary input relationship: RO:0004009 CHEBI:35757 ! has primary input creation_date: 2010-11-02T04:41:55Z [Term] id: GO:0072330 name: monocarboxylic acid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of monocarboxylic acids, any organic acid containing one carboxyl (-COOH) group." [GOC:mah] synonym: "monocarboxylic acid anabolism" EXACT [GOC:mah] synonym: "monocarboxylic acid biosynthesis" EXACT [GOC:mah] synonym: "monocarboxylic acid formation" EXACT [GOC:mah] synonym: "monocarboxylic acid synthesis" EXACT [GOC:mah] is_a: GO:0032787 ! monocarboxylic acid metabolic process is_a: GO:0046394 ! carboxylic acid biosynthetic process intersection_of: GO:0009058 ! biosynthetic process intersection_of: RO:0004008 CHEBI:35757 ! has primary output relationship: RO:0004008 CHEBI:35757 ! has primary output creation_date: 2010-11-02T04:51:32Z [Term] id: GO:0072337 name: modified amino acid transport namespace: biological_process def: "The directed movement of modified amino acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah] subset: gocheck_do_not_annotate synonym: "amino acid derivative transport" EXACT [] is_a: GO:0071705 ! nitrogen compound transport intersection_of: GO:0006810 ! transport intersection_of: RO:0004009 CHEBI:83821 ! has primary input relationship: RO:0004009 CHEBI:83821 ! has primary input creation_date: 2010-11-04T12:18:23Z [Term] id: GO:0072341 name: modified amino acid binding namespace: molecular_function def: "Binding to a modified amino acid." [GOC:mah] synonym: "amino acid derivative binding" EXACT [] is_a: BFO:0000003 is_a: GO:0005488 ! binding intersection_of: GO:0005488 ! binding intersection_of: RO:0004009 CHEBI:83821 ! has primary input relationship: RO:0004009 CHEBI:83821 ! has primary input creation_date: 2010-11-04T05:45:32Z [Term] id: GO:0072343 name: pancreatic stellate cell proliferation namespace: biological_process def: "The multiplication or reproduction of pancreatic stellate cells, resulting in the expansion of a pancreatic stellate cell population. Pancreatic stellate cells are found in the periacinar space of the exocrine pancreas and in perivascular and periductal regions of the pancreas, and have long cytoplasmic processes that encircle the base of the acinus." [CL:0002410, GOC:mah, PMID:17200706] is_a: GO:0048144 ! fibroblast proliferation intersection_of: GO:0008283 ! cell population proliferation intersection_of: RO:0012003 CL:0002410 ! acts on population of pancreatic stellate cell relationship: RO:0012003 CL:0002410 ! acts on population of pancreatic stellate cell property_value: RO:0002161 NCBITaxon:4751 creation_date: 2010-11-05T03:04:50Z [Term] id: GO:0072348 name: sulfur compound transport namespace: biological_process def: "The directed movement of compounds that contain sulfur, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah] synonym: "sulfur-containing compound transport" EXACT [GOC:mah] is_a: BFO:0000003 is_a: GO:0006810 ! transport intersection_of: GO:0006810 ! transport intersection_of: RO:0004009 CHEBI:26835 ! has primary input relationship: RO:0004009 CHEBI:26835 ! has primary input creation_date: 2010-11-11T11:43:56Z [Term] id: GO:0072349 name: modified amino acid transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of modified amino acids from one side of a membrane to the other." [GOC:mah] synonym: "amino acid derivative transmembrane transporter activity" EXACT [] synonym: "modified amino acid transporter activity" BROAD [GOC:mah] is_a: GO:0022857 ! transmembrane transporter activity intersection_of: GO:0022857 ! transmembrane transporter activity intersection_of: RO:0004009 CHEBI:83821 ! has primary input relationship: BFO:0000050 GO:0072337 ! part of modified amino acid transport relationship: RO:0004009 CHEBI:83821 ! has primary input creation_date: 2010-11-11T11:50:31Z [Term] id: GO:0072359 name: circulatory system development namespace: biological_process def: "The process whose specific outcome is the progression of the circulatory system over time, from its formation to the mature structure. The circulatory system is the organ system that passes nutrients (such as amino acids and electrolytes), gases, hormones, blood cells, etc. to and from cells in the body to help fight diseases and help stabilize body temperature and pH to maintain homeostasis." [GOC:mah, UBERON:0001009] subset: goslim_drosophila synonym: "cardiovascular system development" NARROW [] is_a: GO:0048731 ! system development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0001009 ! results in development of circulatory system relationship: RO:0002296 UBERON:0001009 ! results in development of circulatory system creation_date: 2010-11-16T11:27:39Z [Term] id: GO:0072360 name: vascular cord development namespace: biological_process def: "The progression of the vascular cord over time from its initial formation until its mature state. The vascular cord is the primordial vasculature that will develop into blood vessels by the process of tubulogenesis." [GOC:mah, PMID:7084422, ZFA:0005077] is_a: GO:0048856 ! anatomical structure development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0006965 ! results in development of vascular cord relationship: BFO:0000050 GO:0072359 ! part of circulatory system development relationship: RO:0002296 UBERON:0006965 ! results in development of vascular cord creation_date: 2010-11-16T11:46:55Z [Term] id: GO:0072384 name: organelle transport along microtubule namespace: biological_process def: "The directed movement of an organelle along a microtubule, mediated by motor proteins. This process begins with the attachment of an organelle to a microtubule, and ends when the organelle reaches its final destination." [GOC:mah] synonym: "microtubule-based organelle localization" EXACT [GOC:rl] is_a: GO:0010970 ! transport along microtubule is_a: GO:0051656 ! establishment of organelle localization intersection_of: GO:0046907 ! intracellular transport intersection_of: RO:0002341 GO:0005874 ! results in transport along microtubule intersection_of: RO:0004009 GO:0043226 ! has primary input organelle creation_date: 2010-12-01T04:59:11Z [Term] id: GO:0072488 name: ammonium transmembrane transport namespace: biological_process def: "The process in which ammonium is transported across a membrane. Ammonium is the cation NH4+." [GOC:mah] comment: Note that this term is not intended for use in annotating lateral movement within membranes. synonym: "ammonia transport" BROAD [] synonym: "ammonium membrane transport" EXACT [] synonym: "ammonium transport" BROAD [] is_a: GO:0055085 ! transmembrane transport is_a: GO:0071705 ! nitrogen compound transport intersection_of: GO:0055085 ! transmembrane transport intersection_of: RO:0004009 CHEBI:28938 ! has primary input relationship: RO:0004009 CHEBI:28938 ! has primary input property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/22228" xsd:anyURI creation_date: 2010-12-10T10:29:57Z [Term] id: GO:0072497 name: mesenchymal stem cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a mesenchymal stem cell. A mesenchymal stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized mesenchymal cells." [CL:0002452, GOC:BHF] is_a: GO:0048863 ! stem cell differentiation creation_date: 2010-12-15T12:59:30Z [Term] id: GO:0072520 name: seminiferous tubule development namespace: biological_process def: "The reproductive developmental process whose specific outcome is the progression of the seminiferous tubule over time, from its formation to the mature structure. Seminiferous tubules are ducts located in the testicles, and are the specific location of meiosis, and the subsequent creation of gametes, namely spermatozoa." [GOC:BHF, GOC:mah, UBERON:0001343] is_a: GO:0035295 ! tube development is_a: GO:0048608 ! reproductive structure development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0001343 ! results in development of seminiferous tubule of testis relationship: BFO:0000050 GO:0008584 ! part of male gonad development relationship: RO:0002296 UBERON:0001343 ! results in development of seminiferous tubule of testis creation_date: 2011-01-04T12:50:36Z [Term] id: GO:0072521 name: purine-containing compound metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a purine-containing compound, i.e. any compound that contains purine or a formal derivative thereof." [GOC:mah] synonym: "purine and derivative metabolic process" EXACT [] synonym: "purine-containing compound metabolism" EXACT [GOC:mah] is_a: BFO:0000003 is_a: GO:0008152 ! metabolic process intersection_of: GO:0008152 ! metabolic process intersection_of: RO:0004007 CHEBI:26401 ! has primary input or output relationship: RO:0004007 CHEBI:26401 ! has primary input or output creation_date: 2011-01-04T03:03:59Z [Term] id: GO:0072522 name: purine-containing compound biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a purine-containing compound, i.e. any compound that contains purine or a formal derivative thereof." [GOC:mah] synonym: "purine and derivative biosynthetic process" EXACT [] synonym: "purine-containing compound anabolism" EXACT [GOC:mah] synonym: "purine-containing compound biosynthesis" EXACT [GOC:mah] synonym: "purine-containing compound formation" EXACT [GOC:mah] synonym: "purine-containing compound synthesis" EXACT [GOC:mah] is_a: GO:0009058 ! biosynthetic process is_a: GO:0072521 ! purine-containing compound metabolic process intersection_of: GO:0009058 ! biosynthetic process intersection_of: RO:0004008 CHEBI:26401 ! has primary output relationship: RO:0004008 CHEBI:26401 ! has primary output creation_date: 2011-01-04T03:15:29Z [Term] id: GO:0072523 name: purine-containing compound catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of a purine-containing compound, i.e. any compound that contains purine or a formal derivative thereof." [GOC:mah] synonym: "purine and derivative catabolic process" EXACT [] synonym: "purine-containing compound breakdown" EXACT [GOC:mah] synonym: "purine-containing compound catabolism" EXACT [GOC:mah] synonym: "purine-containing compound degradation" EXACT [GOC:mah] is_a: GO:0009056 ! catabolic process is_a: GO:0072521 ! purine-containing compound metabolic process intersection_of: GO:0009056 ! catabolic process intersection_of: RO:0004009 CHEBI:26401 ! has primary input relationship: RO:0004009 CHEBI:26401 ! has primary input creation_date: 2011-01-04T03:17:20Z [Term] id: GO:0072530 name: purine-containing compound transmembrane transport namespace: biological_process def: "The process in which a purine-containing compound is transported across a membrane. A purine-containing compound is any compound that contains purine or a formal derivative thereof." [GOC:mah] comment: Note that this term is not intended for use in annotating lateral movement within membranes. synonym: "purine-containing compound membrane transport" EXACT [] xref: Reactome:R-HSA-2161517 "Abacavir transmembrane transport" is_a: GO:0055085 ! transmembrane transport is_a: GO:0071705 ! nitrogen compound transport intersection_of: GO:0055085 ! transmembrane transport intersection_of: RO:0004009 CHEBI:26401 ! has primary input relationship: RO:0004009 CHEBI:26401 ! has primary input creation_date: 2011-01-05T01:45:14Z [Term] id: GO:0072537 name: fibroblast activation namespace: biological_process def: "A change in the morphology or behavior of a fibroblast resulting from exposure to an activating factor such as a cellular or soluble ligand." [CL:0000057, GOC:BHF, GOC:mah] is_a: BFO:0000003 is_a: GO:0001775 ! cell activation intersection_of: GO:0001775 ! cell activation intersection_of: RO:0004009 CL:0000057 ! has primary input fibroblast relationship: RO:0004009 CL:0000057 ! has primary input fibroblast creation_date: 2011-01-14T04:35:08Z [Term] id: GO:0072538 name: T-helper 17 type immune response namespace: biological_process def: "An immune response which is associated with resistance to intracellular bacteria with a key role in inflammation and tissue injury. This immune response is associated with pathological autoimmune conditions such as multiple sclerosis, arthritis and psoriasis which is typically orchestrated by the production of particular cytokines by T-helper 17 cells, most notably interleukin-17, IL-21 and IL-22." [GOC:BHF, GOC:ebc] synonym: "Th17 immune response" EXACT [GOC:mah] is_a: BFO:0000003 is_a: GO:0002460 ! adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains relationship: has_participant CL:0000899 ! T-helper 17 cell creation_date: 2011-01-17T11:13:53Z [Term] id: GO:0072539 name: T-helper 17 cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized T cell acquires the specialized features of a T-helper 17 (Th17) cell. A Th17 cell is a CD4-positive, alpha-beta T cell with the phenotype RORgamma-t-positive that produces IL-17." [CL:0000899, GOC:BHF, GOC:ebc] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "T-helper 17 cell development" RELATED [GOC:mah] is_a: GO:0042093 ! T-helper cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000899 ! results in acquisition of features of T-helper 17 cell relationship: BFO:0000050 GO:0072538 ! part of T-helper 17 type immune response relationship: RO:0002315 CL:0000899 ! results in acquisition of features of T-helper 17 cell creation_date: 2011-01-17T11:18:47Z [Term] id: GO:0072553 name: terminal button organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a terminal button. A terminal button is the terminal inflated portion of the axon, containing the specialized apparatus necessary to release neurotransmitters." [GOC:BHF, GOC:mah] synonym: "bouton organization" EXACT [GOC:mah] synonym: "presynaptic bouton organization" EXACT [GOC:mah] synonym: "synaptic bouton organization" EXACT [GOC:mah] synonym: "terminal bouton organization" EXACT [GOC:mah] synonym: "terminal button organisation" EXACT [GOC:mah] is_a: GO:0099172 ! presynapse organization intersection_of: GO:0016043 ! cellular component organization intersection_of: RO:0002592 GO:0043195 ! results in organization of terminal bouton relationship: RO:0002592 GO:0043195 ! results in organization of terminal bouton creation_date: 2011-01-25T04:09:35Z [Term] id: GO:0072560 name: type B pancreatic cell maturation namespace: biological_process def: "A developmental process, independent of morphogenetic (shape) change, that is required for a type B pancreatic cell to attain its fully functional state. A type B pancreatic cell is a cell located towards center of the islets of Langerhans that secretes insulin." [CL:0000169, GOC:BHF] comment: These processes continue to 60 DPA in Gossypium spp. synonym: "pancreatic B cell maturation" EXACT [CL:0000169, GOC:mah] synonym: "pancreatic beta cell maturation" EXACT [CL:0000169, GOC:mah] is_a: GO:0002070 ! epithelial cell maturation intersection_of: GO:0021700 ! developmental maturation intersection_of: RO:0002299 CL:0000169 ! results in maturation of type B pancreatic cell relationship: BFO:0000050 GO:0003323 ! part of type B pancreatic cell development relationship: RO:0002299 CL:0000169 ! results in maturation of type B pancreatic cell creation_date: 2011-01-27T01:57:14Z [Term] id: GO:0072575 name: epithelial cell proliferation involved in liver morphogenesis namespace: biological_process def: "The multiplication or reproduction of epithelial cells, resulting in the expansion of a cell population that contributes to the shaping of the liver." [GOC:BHF, GOC:mah] is_a: GO:0050673 ! epithelial cell proliferation intersection_of: GO:0050673 ! epithelial cell proliferation intersection_of: BFO:0000050 GO:0072576 ! part of liver morphogenesis relationship: BFO:0000050 GO:0072576 ! part of liver morphogenesis creation_date: 2011-02-02T03:37:50Z [Term] id: GO:0072576 name: liver morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the liver are generated and organized." [GOC:mah] is_a: GO:0022612 ! gland morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0002107 ! results in morphogenesis of liver relationship: BFO:0000050 GO:0001889 ! part of liver development relationship: RO:0002298 UBERON:0002107 ! results in morphogenesis of liver creation_date: 2011-02-02T03:41:30Z [Term] id: GO:0072577 name: endothelial cell apoptotic process namespace: biological_process def: "Any apoptotic process in an endothelial cell. An endothelial cell comprises the outermost layer or lining of anatomical structures and can be squamous or cuboidal." [CL:0000115, GOC:BHF, GOC:mah, GOC:mtg_apoptosis] synonym: "apoptosis of endothelial cells" EXACT [GOC:mah] synonym: "endothelial cell apoptosis" NARROW [] synonym: "endothelial cell programmed cell death by apoptosis" EXACT [GOC:mah] synonym: "killing of endothelial cells" EXACT [GOC:mah] synonym: "programmed cell death of endothelial cells by apoptosis" EXACT [GOC:mah] synonym: "programmed cell death, endothelial cells" EXACT [GOC:mah] is_a: GO:0006915 ! apoptotic process intersection_of: GO:0006915 ! apoptotic process intersection_of: BFO:0000066 CL:0000115 ! occurs in endothelial cell relationship: BFO:0000066 CL:0000115 ! occurs in endothelial cell property_value: RO:0002161 NCBITaxon:4896 creation_date: 2011-02-02T03:56:24Z [Term] id: GO:0072592 name: oxygen metabolic process namespace: biological_process def: "The chemical reactions and pathways involving diatomic oxygen (O2)." [GOC:mah] synonym: "diatomic oxygen metabolic process" EXACT [CHEBI:33263] synonym: "oxygen metabolism" EXACT [GOC:mah] is_a: BFO:0000003 is_a: GO:0008152 ! metabolic process intersection_of: GO:0008152 ! metabolic process intersection_of: RO:0004007 CHEBI:15379 ! has primary input or output relationship: RO:0004007 CHEBI:15379 ! has primary input or output creation_date: 2011-02-11T10:46:51Z [Term] id: GO:0072593 name: reactive oxygen species metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a reactive oxygen species, any molecules or ions formed by the incomplete one-electron reduction of oxygen. They contribute to the microbicidal activity of phagocytes, regulation of signal transduction and gene expression, and the oxidative damage to biopolymers." [GOC:mah] synonym: "reactive oxygen species metabolism" EXACT [GOC:mah] synonym: "ROS metabolic process" EXACT [CHEBI:26523, GOC:mah] is_a: BFO:0000003 is_a: GO:0008152 ! metabolic process intersection_of: GO:0008152 ! metabolic process intersection_of: RO:0004007 CHEBI:26523 ! has primary input or output relationship: RO:0004007 CHEBI:26523 ! has primary input or output creation_date: 2011-02-11T10:50:06Z [Term] id: GO:0072594 name: establishment of protein localization to organelle namespace: biological_process def: "The directed movement of a protein to a specific location on or in an organelle. Encompasses establishment of localization in the membrane or lumen of a membrane-bounded organelle." [GOC:mah] synonym: "establishment of protein localisation to organelle" EXACT [GOC:mah] is_a: GO:0045184 ! establishment of protein localization intersection_of: GO:0045184 ! establishment of protein localization intersection_of: RO:0002339 GO:0043226 ! has target end location organelle relationship: RO:0002339 GO:0043226 ! has target end location organelle creation_date: 2011-02-14T01:56:51Z [Term] id: GO:0072595 name: maintenance of protein localization in organelle namespace: biological_process def: "Any process in which a protein is maintained in a specific location a specific location on or in an organelle, and is prevented from moving elsewhere. Encompasses establishment of localization in the membrane or lumen of a membrane-bounded organelle." [GOC:mah] synonym: "maintenance of protein localisation to organelle" EXACT [GOC:mah] synonym: "maintenance of protein localization to organelle" EXACT [] is_a: GO:0032507 ! maintenance of protein location in cell intersection_of: GO:0045185 ! maintenance of protein location intersection_of: BFO:0000066 GO:0043226 ! occurs in organelle relationship: BFO:0000050 GO:0033365 ! part of protein localization to organelle relationship: BFO:0000066 GO:0043226 ! occurs in organelle creation_date: 2011-02-14T02:09:13Z [Term] id: GO:0072596 name: establishment of protein localization to chloroplast namespace: biological_process def: "The directed movement of a protein to a specific location in a chloroplast." [GOC:mah] synonym: "establishment of protein localisation to chloroplast" EXACT [GOC:mah] is_a: GO:0072594 ! establishment of protein localization to organelle intersection_of: GO:0045184 ! establishment of protein localization intersection_of: RO:0002339 GO:0009507 ! has target end location chloroplast relationship: RO:0002339 GO:0009507 ! has target end location chloroplast creation_date: 2011-02-14T02:16:13Z [Term] id: GO:0072597 name: maintenance of protein location in chloroplast namespace: biological_process def: "Any process in which a protein is maintained in a specific location in a chloroplast, and is prevented from moving elsewhere." [GOC:mah] is_a: GO:0072595 ! maintenance of protein localization in organelle intersection_of: GO:0045185 ! maintenance of protein location intersection_of: BFO:0000066 GO:0009507 ! occurs in chloroplast relationship: BFO:0000050 GO:0072598 ! part of protein localization to chloroplast relationship: BFO:0000066 GO:0009507 ! occurs in chloroplast property_value: RO:0002161 NCBITaxon:28009 property_value: RO:0002161 NCBITaxon:33208 property_value: RO:0002161 NCBITaxon:4751 property_value: RO:0002161 NCBITaxon:554915 creation_date: 2011-02-14T02:17:48Z [Term] id: GO:0072598 name: protein localization to chloroplast namespace: biological_process def: "A process in which a protein is transported to, or maintained at, a location in a chloroplast." [GOC:ecd] synonym: "protein localisation to chloroplast" EXACT [GOC:mah] is_a: GO:0033365 ! protein localization to organelle intersection_of: GO:0008104 ! intracellular protein localization intersection_of: RO:0002339 GO:0009507 ! has target end location chloroplast relationship: RO:0002339 GO:0009507 ! has target end location chloroplast creation_date: 2011-02-14T02:20:30Z [Term] id: GO:0072655 name: establishment of protein localization to mitochondrion namespace: biological_process def: "The directed movement of a protein to the mitochondrion or a part of the mitochondrion." [GOC:mah] synonym: "establishment of protein localisation to mitochondrion" EXACT [GOC:mah] synonym: "establishment of protein localization in mitochondrion" EXACT [] is_a: GO:0072594 ! establishment of protein localization to organelle intersection_of: GO:0045184 ! establishment of protein localization intersection_of: RO:0002339 GO:0005739 ! has target end location mitochondrion relationship: RO:0002339 GO:0005739 ! has target end location mitochondrion creation_date: 2011-02-14T02:28:54Z [Term] id: GO:0072656 name: maintenance of protein location in mitochondrion namespace: biological_process def: "Any process in which a protein is maintained in a specific location in a mitochondrion, and is prevented from moving elsewhere." [GOC:mah] is_a: GO:0072595 ! maintenance of protein localization in organelle intersection_of: GO:0045185 ! maintenance of protein location intersection_of: BFO:0000066 GO:0005739 ! occurs in mitochondrion relationship: BFO:0000050 GO:0070585 ! part of protein localization to mitochondrion relationship: BFO:0000066 GO:0005739 ! occurs in mitochondrion relationship: RO:0002162 NCBITaxon:2759 ! in taxon Eukaryota creation_date: 2011-02-14T02:30:43Z [Term] id: GO:0072657 name: protein localization to membrane namespace: biological_process def: "A process in which a protein is transported to, or maintained in, a specific location in a membrane." [GOC:mah] subset: goslim_prokaryote synonym: "protein localisation in membrane" EXACT [GOC:mah] synonym: "protein localization in membrane" EXACT [] is_a: GO:0008104 ! intracellular protein localization is_a: GO:0051668 ! localization within membrane intersection_of: GO:0008104 ! intracellular protein localization intersection_of: RO:0002339 GO:0016020 ! has target end location membrane creation_date: 2011-02-14T02:35:18Z [Term] id: GO:0072659 name: protein localization to plasma membrane namespace: biological_process def: "A process in which a protein is transported to, or maintained in, a specific location in the plasma membrane." [GOC:mah] subset: goslim_generic subset: goslim_pombe synonym: "protein localisation in plasma membrane" RELATED [GOC:mah] synonym: "protein localization in plasma membrane" RELATED [] synonym: "protein targeting to plasma membrane" RELATED [] synonym: "protein-plasma membrane targeting" RELATED [GOC:mah] is_a: GO:0072657 ! protein localization to membrane is_a: GO:1990778 ! protein localization to cell periphery intersection_of: GO:0008104 ! intracellular protein localization intersection_of: RO:0002338 GO:0005622 ! has target start location intracellular anatomical structure intersection_of: RO:0002339 GO:0005886 ! has target end location plasma membrane relationship: RO:0002338 GO:0005622 ! has target start location intracellular anatomical structure relationship: RO:0002339 GO:0005886 ! has target end location plasma membrane creation_date: 2009-07-10T10:29:23Z [Term] id: GO:0072665 name: protein localization to vacuole namespace: biological_process def: "A process in which a protein is transported to, or maintained at, a location in a vacuole." [GOC:ecd] synonym: "protein localisation to vacuole" EXACT [GOC:mah] is_a: GO:0033365 ! protein localization to organelle intersection_of: GO:0008104 ! intracellular protein localization intersection_of: RO:0002339 GO:0005773 ! has target end location vacuole relationship: RO:0002339 GO:0005773 ! has target end location vacuole creation_date: 2011-02-14T02:55:35Z [Term] id: GO:0072666 name: establishment of protein localization to vacuole namespace: biological_process def: "The directed movement of a protein to a specific location in a vacuole." [GOC:mah] synonym: "establishment of protein localisation to vacuole" EXACT [GOC:mah] is_a: GO:0072594 ! establishment of protein localization to organelle intersection_of: GO:0045184 ! establishment of protein localization intersection_of: RO:0002339 GO:0005773 ! has target end location vacuole relationship: RO:0002339 GO:0005773 ! has target end location vacuole creation_date: 2011-02-14T02:56:29Z [Term] id: GO:0072667 name: maintenance of protein location in vacuole namespace: biological_process def: "Any process in which a protein is maintained in a specific location in a vacuole, and is prevented from moving elsewhere." [GOC:mah] is_a: GO:0072595 ! maintenance of protein localization in organelle intersection_of: GO:0045185 ! maintenance of protein location intersection_of: BFO:0000066 GO:0005773 ! occurs in vacuole relationship: BFO:0000050 GO:0072665 ! part of protein localization to vacuole relationship: BFO:0000066 GO:0005773 ! occurs in vacuole creation_date: 2011-02-14T02:56:57Z [Term] id: GO:0072674 name: multinuclear osteoclast differentiation namespace: biological_process def: "The process in which a relatively unspecialized monocyte acquires the specialized features of a multinuclear osteoclast. An osteoclast is a specialized phagocytic cell associated with the absorption and removal of the mineralized matrix of bone tissue." [CL:0000779, GOC:mah, PMID:12713016] synonym: "multinuclear osteoclast formation" RELATED [GOC:BHF, GOC:mah] synonym: "multinuclear osteoclast morphogenesis" RELATED [GOC:BHF, GOC:mah] is_a: GO:0030316 ! osteoclast differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000779 ! results in acquisition of features of multinuclear osteoclast relationship: RO:0002315 CL:0000779 ! results in acquisition of features of multinuclear osteoclast creation_date: 2011-02-22T02:10:38Z [Term] id: GO:0072676 name: lymphocyte migration namespace: biological_process def: "The movement of a lymphocyte within or between different tissues and organs of the body." [CL:0000542, GOC:BHF, GOC:mah] is_a: GO:0071674 ! mononuclear cell migration intersection_of: GO:0016477 ! cell migration intersection_of: RO:0002565 CL:0000542 ! results in movement of lymphocyte relationship: RO:0002565 CL:0000542 ! results in movement of lymphocyte creation_date: 2011-02-22T03:38:12Z [Term] id: GO:0072677 name: eosinophil migration namespace: biological_process def: "The movement of an eosinophil within or between different tissues and organs of the body." [CL:0000771, GOC:BHF, GOC:mah] is_a: GO:0097530 ! granulocyte migration intersection_of: GO:0016477 ! cell migration intersection_of: RO:0002565 CL:0000771 ! results in movement of eosinophil relationship: RO:0002565 CL:0000771 ! results in movement of eosinophil creation_date: 2011-02-22T03:39:31Z [Term] id: GO:0072678 name: T cell migration namespace: biological_process def: "The movement of a T cell within or between different tissues and organs of the body." [CL:0000084, GOC:BHF, GOC:mah] synonym: "T lymphocyte migration" EXACT [CL:0000084] synonym: "T-cell migration" EXACT [CL:0000084] synonym: "T-lymphocyte migration" EXACT [CL:0000084] is_a: GO:0072676 ! lymphocyte migration intersection_of: GO:0016477 ! cell migration intersection_of: RO:0002565 CL:0000084 ! results in movement of T cell relationship: RO:0002565 CL:0000084 ! results in movement of T cell creation_date: 2011-02-22T03:40:40Z [Term] id: GO:0072679 name: thymocyte migration namespace: biological_process def: "The movement of a thymocyte through distinct intrathymic niches (e.g. medulla, cortex), where it receives a unique set of developmental cues required for T-cell development." [CL:0000893, GOC:BHF, GOC:mah] synonym: "immature T cell migration" RELATED [CL:0000893] synonym: "immature T lymphocyte migration" RELATED [CL:0000893] synonym: "immature T-cell migration" RELATED [CL:0000893] synonym: "immature T-lymphocyte migration" RELATED [CL:0000893] synonym: "thymic lymphocyte migration" EXACT [CL:0000893] is_a: GO:0072678 ! T cell migration intersection_of: GO:0016477 ! cell migration intersection_of: RO:0002565 CL:0000893 ! results in movement of thymocyte relationship: RO:0002565 CL:0000893 ! results in movement of thymocyte creation_date: 2011-02-22T03:47:51Z [Term] id: GO:0072697 name: protein localization to cell cortex namespace: biological_process def: "A process in which a protein is transported to, or maintained in, the cell cortex." [GOC:mah] synonym: "protein localisation to cell cortex" EXACT [GOC:mah] is_a: GO:1990778 ! protein localization to cell periphery intersection_of: GO:0008104 ! intracellular protein localization intersection_of: RO:0002339 GO:0005938 ! has target end location cell cortex relationship: RO:0002339 GO:0005938 ! has target end location cell cortex creation_date: 2012-04-11T01:16:33Z [Term] id: GO:0072698 name: protein localization to microtubule cytoskeleton namespace: biological_process def: "A cellular protein localization process in which a protein is transported to, or maintained at, a location within the microtubule cytoskeleton." [GOC:mah] synonym: "protein localisation to microtubule cytoskeleton" EXACT [GOC:mah] is_a: GO:0044380 ! protein localization to cytoskeleton intersection_of: GO:0008104 ! intracellular protein localization intersection_of: RO:0002339 GO:0015630 ! has target end location microtubule cytoskeleton relationship: RO:0002339 GO:0015630 ! has target end location microtubule cytoskeleton creation_date: 2012-04-11T01:19:35Z [Term] id: GO:0075296 name: positive regulation of ascospore formation namespace: biological_process def: "Any process that activates, maintains or increases the frequency, rate or extent of ascospore formation, a process in which a sexual spore, named ascospore, from Ascomycete fungi was produced inside an ascus." [GOC:pamgo_curators] is_a: GO:0010720 ! positive regulation of cell development is_a: GO:0034307 ! regulation of ascospore formation is_a: GO:0043941 ! positive regulation of sexual sporulation resulting in formation of a cellular spore is_a: GO:0090068 ! positive regulation of cell cycle process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0030437 ! positively regulates ascospore formation relationship: RO:0002213 GO:0030437 ! positively regulates ascospore formation [Term] id: GO:0075297 name: negative regulation of ascospore formation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of ascospore formation, a process in which a sexual spore, named ascospore, from Ascomycete fungi was produced inside an ascus." [GOC:pamgo_curators] is_a: GO:0010721 ! negative regulation of cell development is_a: GO:0010948 ! negative regulation of cell cycle process is_a: GO:0034307 ! regulation of ascospore formation is_a: GO:0043942 ! negative regulation of sexual sporulation resulting in formation of a cellular spore intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0030437 ! negatively regulates ascospore formation relationship: RO:0002212 GO:0030437 ! negatively regulates ascospore formation [Term] id: GO:0075298 name: regulation of zygospore formation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of zygospore formation, a process in which a thick-walled spore of some algae and fungi is formed by union of two similar sexual cells, usually serves as a resting spore, and produces the sporophytic phase." [GOC:pamgo_curators] is_a: GO:0043940 ! regulation of sexual sporulation resulting in formation of a cellular spore intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0034296 ! regulates zygospore formation relationship: RO:0002211 GO:0034296 ! regulates zygospore formation [Term] id: GO:0075299 name: positive regulation of zygospore formation namespace: biological_process def: "Any process that activates, maintains or increases the frequency, rate or extent of frequency, rate or extent of zygospore formation, a process in which a thick-walled spore of some algae and fungi is formed by union of two similar sexual cells, usually serves as a resting spore, and produces the sporophytic phase." [GOC:pamgo_curators] is_a: GO:0043941 ! positive regulation of sexual sporulation resulting in formation of a cellular spore is_a: GO:0075298 ! regulation of zygospore formation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0034296 ! positively regulates zygospore formation relationship: RO:0002213 GO:0034296 ! positively regulates zygospore formation [Term] id: GO:0075300 name: negative regulation of zygospore formation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of zygospore formation, a process in which a thick-walled spore of some algae and fungi is formed by union of two similar sexual cells, usually serves as a resting spore, and produces the sporophytic phase." [GOC:pamgo_curators] is_a: GO:0043942 ! negative regulation of sexual sporulation resulting in formation of a cellular spore is_a: GO:0075298 ! regulation of zygospore formation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0034296 ! negatively regulates zygospore formation relationship: RO:0002212 GO:0034296 ! negatively regulates zygospore formation [Term] id: GO:0075302 name: regulation of basidiospore formation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of basidiospore formation, a process in which a sexually produced fungal spore is formed on a basidium in the fungi Basidiomycetes." [GOC:pamgo_curators] is_a: GO:0043940 ! regulation of sexual sporulation resulting in formation of a cellular spore intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0034295 ! regulates basidiospore formation relationship: RO:0002211 GO:0034295 ! regulates basidiospore formation [Term] id: GO:0075303 name: positive regulation of basidiospore formation namespace: biological_process def: "Any process that activates, maintains or increases the frequency, rate or extent of frequency, rate or extent of basidiospore formation, a process in which a sexually produced fungal spore is formed on a basidium in the fungi basidiomycetes." [GOC:pamgo_curators] is_a: GO:0043941 ! positive regulation of sexual sporulation resulting in formation of a cellular spore is_a: GO:0075302 ! regulation of basidiospore formation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0034295 ! positively regulates basidiospore formation relationship: RO:0002213 GO:0034295 ! positively regulates basidiospore formation [Term] id: GO:0075304 name: negative regulation of basidiospore formation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of basidiospore formation, a process in which a sexually produced fungal spore is formed on a basidium in the fungi basidiomycetes." [GOC:pamgo_curators] is_a: GO:0043942 ! negative regulation of sexual sporulation resulting in formation of a cellular spore is_a: GO:0075302 ! regulation of basidiospore formation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0034295 ! negatively regulates basidiospore formation relationship: RO:0002212 GO:0034295 ! negatively regulates basidiospore formation [Term] id: GO:0080090 name: regulation of primary metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism involving those compounds formed as a part of the normal anabolic and catabolic processes. These processes take place in most, if not all, cells of the organism." [PMID:19211694] is_a: GO:0019222 ! regulation of metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0044238 ! regulates primary metabolic process relationship: RO:0002211 GO:0044238 ! regulates primary metabolic process creation_date: 2009-04-22T04:30:52Z [Term] id: GO:0080134 name: regulation of response to stress namespace: biological_process def: "Any process that modulates the frequency, rate or extent of a response to stress. Response to stress is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:dhl] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_annotate is_a: GO:0048583 ! regulation of response to stimulus intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0006950 ! regulates response to stress relationship: RO:0002211 GO:0006950 ! regulates response to stress creation_date: 2009-05-06T04:51:28Z [Term] id: GO:0080135 name: regulation of cellular response to stress namespace: biological_process def: "Any process that modulates the frequency, rate or extent of a cellular response to stress. Cellular response to stress is a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:dhl] is_a: GO:0050794 ! regulation of cellular process is_a: GO:0080134 ! regulation of response to stress intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0033554 ! regulates cellular response to stress relationship: RO:0002211 GO:0033554 ! regulates cellular response to stress creation_date: 2009-05-06T05:02:52Z [Term] id: GO:0080144 name: intracellular amino acid homeostasis namespace: biological_process def: "A homeostatic process involved in the maintenance of a steady state level of amino acids within a cell." [PMID:19955263] synonym: "amino acid homeostasis" BROAD [] synonym: "cellular amino acid homeostasis" EXACT [] is_a: GO:0055082 ! intracellular chemical homeostasis intersection_of: GO:0055082 ! intracellular chemical homeostasis intersection_of: RO:0002332 CHEBI:35238 ! regulates levels of relationship: RO:0002332 CHEBI:35238 ! regulates levels of creation_date: 2010-01-27T04:47:27Z [Term] id: GO:0080154 name: regulation of fertilization namespace: biological_process def: "Any process that modulates the rate, frequency or extent of fertilization. Fertilization is the union of gametes of opposite sexes during the process of sexual reproduction to form a zygote. It involves the fusion of the gametic nuclei (karyogamy) and cytoplasm (plasmogamy)." [GOC:DHL, PMID:20478994] is_a: GO:2000241 ! regulation of reproductive process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0009566 ! regulates fertilization relationship: RO:0002211 GO:0009566 ! regulates fertilization creation_date: 2010-09-01T03:44:27Z [Term] id: GO:0080164 name: regulation of nitric oxide metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving nitric oxide, nitrogen monoxide (NO), a colorless gas only slightly soluble in water." [GOC:DHL] is_a: GO:0019222 ! regulation of metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0046209 ! regulates nitric oxide metabolic process relationship: RO:0002211 GO:0046209 ! regulates nitric oxide metabolic process creation_date: 2010-09-23T04:02:50Z [Term] id: GO:0080171 name: lytic vacuole organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a lytic vacuole." [PMID:20729380] synonym: "lytic vacuolar assembly" NARROW [] synonym: "lytic vacuole biogenesis" RELATED [] synonym: "lytic vacuole organisation" EXACT [] synonym: "lytic vacuole organization and biogenesis" RELATED [] is_a: GO:0007033 ! vacuole organization intersection_of: GO:0016043 ! cellular component organization intersection_of: RO:0002592 GO:0000323 ! results in organization of lytic vacuole relationship: RO:0002592 GO:0000323 ! results in organization of lytic vacuole creation_date: 2011-04-25T04:40:46Z [Term] id: GO:0085029 name: extracellular matrix assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of the extracellular matrix." [GOC:jl] is_a: GO:0022607 ! cellular component assembly is_a: GO:0030198 ! extracellular matrix organization intersection_of: GO:0022607 ! cellular component assembly intersection_of: RO:0002588 GO:0031012 ! results in assembly of extracellular matrix relationship: RO:0002588 GO:0031012 ! results in assembly of extracellular matrix creation_date: 2010-07-14T12:52:49Z [Term] id: GO:0086001 name: cardiac muscle cell action potential namespace: biological_process def: "An action potential that occurs in a cardiac muscle cell." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] is_a: GO:0001508 ! action potential intersection_of: GO:0001508 ! action potential intersection_of: BFO:0000066 CL:0000746 ! occurs in cardiac muscle cell relationship: BFO:0000066 CL:0000746 ! occurs in cardiac muscle cell property_value: RO:0002161 NCBITaxon:4895 creation_date: 2011-11-10T07:45:11Z [Term] id: GO:0086002 name: cardiac muscle cell action potential involved in contraction namespace: biological_process def: "An action potential that occurs in a cardiac muscle cell and is involved in its contraction." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] is_a: GO:0086001 ! cardiac muscle cell action potential intersection_of: GO:0086001 ! cardiac muscle cell action potential intersection_of: BFO:0000050 GO:0086003 ! part of cardiac muscle cell contraction relationship: BFO:0000050 GO:0086003 ! part of cardiac muscle cell contraction property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4895 property_value: RO:0002161 NCBITaxon:4932 creation_date: 2011-11-10T07:45:11Z [Term] id: GO:0086003 name: cardiac muscle cell contraction namespace: biological_process def: "The actin filament-based process in which cytoplasmic actin filaments slide past one another resulting in contraction of a cardiac muscle cell." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] is_a: BFO:0000003 is_a: GO:0070252 ! actin-mediated cell contraction relationship: BFO:0000050 GO:0060048 ! part of cardiac muscle contraction property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 creation_date: 2011-11-10T07:48:15Z [Term] id: GO:0086004 name: regulation of cardiac muscle cell contraction namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cardiac muscle cell contraction." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] is_a: GO:0055117 ! regulation of cardiac muscle contraction is_a: GO:1903115 ! regulation of actin filament-based movement intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0086003 ! regulates cardiac muscle cell contraction relationship: RO:0002211 GO:0086003 ! regulates cardiac muscle cell contraction property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 creation_date: 2011-11-10T07:49:10Z [Term] id: GO:0086005 name: ventricular cardiac muscle cell action potential namespace: biological_process def: "An action potential that occurs in a ventricular cardiac muscle cell." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] is_a: GO:0086002 ! cardiac muscle cell action potential involved in contraction intersection_of: GO:0001508 ! action potential intersection_of: BFO:0000066 CL:0002131 ! occurs in regular ventricular cardiac myocyte relationship: BFO:0000066 CL:0002131 ! occurs in regular ventricular cardiac myocyte property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4895 property_value: RO:0002161 NCBITaxon:4932 creation_date: 2011-11-10T07:59:36Z [Term] id: GO:0086006 name: voltage-gated sodium channel activity involved in cardiac muscle cell action potential namespace: molecular_function def: "Enables the transmembrane transfer of a sodium ion by a voltage-gated channel through the plasma membrane of a cardiac muscle cell contributing to the depolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] is_a: GO:0005248 ! voltage-gated sodium channel activity intersection_of: GO:0005248 ! voltage-gated sodium channel activity intersection_of: BFO:0000050 GO:0086012 ! part of membrane depolarization during cardiac muscle cell action potential relationship: BFO:0000050 GO:0086012 ! part of membrane depolarization during cardiac muscle cell action potential property_value: RO:0002161 NCBITaxon:4895 creation_date: 2011-11-10T08:34:49Z [Term] id: GO:0086007 name: voltage-gated calcium channel activity involved in cardiac muscle cell action potential namespace: molecular_function def: "Enables the transmembrane transfer of a calcium ion by a voltage-gated channel across the plasma membrane of a cardiac muscle cell that contributes to the depolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] is_a: GO:0005245 ! voltage-gated calcium channel activity intersection_of: GO:0005245 ! voltage-gated calcium channel activity intersection_of: BFO:0000050 GO:0086012 ! part of membrane depolarization during cardiac muscle cell action potential relationship: BFO:0000050 GO:0086012 ! part of membrane depolarization during cardiac muscle cell action potential property_value: RO:0002161 NCBITaxon:4895 creation_date: 2011-11-10T08:04:42Z [Term] id: GO:0086008 name: voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization namespace: molecular_function def: "Enables the transmembrane transfer of a potassium ion by a voltage-gated channel through the plasma membrane of a cardiac muscle cell contributing to the repolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] is_a: GO:0005249 ! voltage-gated potassium channel activity intersection_of: GO:0005249 ! voltage-gated potassium channel activity intersection_of: BFO:0000050 GO:0086013 ! part of membrane repolarization during cardiac muscle cell action potential relationship: BFO:0000050 GO:0086013 ! part of membrane repolarization during cardiac muscle cell action potential creation_date: 2011-11-10T08:38:09Z [Term] id: GO:0086009 name: membrane repolarization namespace: biological_process def: "The process in which ions are transported across a membrane such that the membrane potential changes in the repolarizing direction, toward the steady state potential. For example, the repolarization during an action potential is from a positive membrane potential towards a negative resting potential." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] is_a: GO:0042391 ! regulation of membrane potential creation_date: 2011-11-10T08:13:18Z [Term] id: GO:0086010 name: membrane depolarization during action potential namespace: biological_process def: "The process in which membrane potential changes in the depolarizing direction from the negative resting potential towards the positive membrane potential that will be the peak of the action potential." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] is_a: GO:0051899 ! membrane depolarization intersection_of: GO:0051899 ! membrane depolarization intersection_of: BFO:0000050 GO:0001508 ! part of action potential relationship: BFO:0000050 GO:0001508 ! part of action potential property_value: RO:0002161 NCBITaxon:4895 creation_date: 2011-11-10T08:15:05Z [Term] id: GO:0086011 name: membrane repolarization during action potential namespace: biological_process def: "The process in which ions are transported across a membrane such that the membrane potential changes in the direction from the positive membrane potential at the peak of the action potential towards the negative resting potential." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] is_a: GO:0086009 ! membrane repolarization intersection_of: GO:0086009 ! membrane repolarization intersection_of: BFO:0000050 GO:0001508 ! part of action potential relationship: BFO:0000050 GO:0001508 ! part of action potential property_value: RO:0002161 NCBITaxon:4895 creation_date: 2011-11-10T08:15:05Z [Term] id: GO:0086012 name: membrane depolarization during cardiac muscle cell action potential namespace: biological_process def: "The process in which cardiac muscle cell membrane potential changes in the depolarizing direction from the negative resting potential towards the positive membrane potential that will be the peak of the action potential." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] is_a: GO:0086010 ! membrane depolarization during action potential intersection_of: GO:0051899 ! membrane depolarization intersection_of: BFO:0000050 GO:0086001 ! part of cardiac muscle cell action potential relationship: BFO:0000050 GO:0086001 ! part of cardiac muscle cell action potential property_value: RO:0002161 NCBITaxon:4895 creation_date: 2011-11-10T08:20:33Z [Term] id: GO:0086013 name: membrane repolarization during cardiac muscle cell action potential namespace: biological_process def: "The process in which ions are transported across a membrane such that the cardiac muscle cell plasma membrane potential changes in the direction from the positive membrane potential at the peak of the action potential towards the negative resting potential." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] is_a: GO:0086011 ! membrane repolarization during action potential is_a: GO:0099622 ! cardiac muscle cell membrane repolarization intersection_of: GO:0086009 ! membrane repolarization intersection_of: BFO:0000050 GO:0086001 ! part of cardiac muscle cell action potential relationship: BFO:0000050 GO:0086001 ! part of cardiac muscle cell action potential creation_date: 2011-11-10T08:23:25Z [Term] id: GO:0086014 name: atrial cardiac muscle cell action potential namespace: biological_process def: "An action potential that occurs in an atrial cardiac muscle cell." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] is_a: GO:0086002 ! cardiac muscle cell action potential involved in contraction intersection_of: GO:0001508 ! action potential intersection_of: BFO:0000066 CL:0002129 ! occurs in regular atrial cardiac myocyte relationship: BFO:0000050 GO:0086026 ! part of atrial cardiac muscle cell to AV node cell signaling relationship: BFO:0000066 CL:0002129 ! occurs in regular atrial cardiac myocyte property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4895 property_value: RO:0002161 NCBITaxon:4932 creation_date: 2011-11-10T08:49:13Z [Term] id: GO:0086015 name: SA node cell action potential namespace: biological_process def: "An action potential that occurs in a sinoatrial node cardiac muscle cell." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] synonym: "SA node cardiac muscle cell action potential" EXACT [] synonym: "SAN cardiac muscle cell action potential" EXACT [] synonym: "sinoatrial node cardiac muscle cell action potential" EXACT [] synonym: "sinus node cardiac muscle cell action potential" NARROW [] is_a: GO:0086001 ! cardiac muscle cell action potential intersection_of: GO:0001508 ! action potential intersection_of: BFO:0000066 CL:1000409 ! occurs in myocyte of sinoatrial node relationship: BFO:0000050 GO:0086018 ! part of SA node cell to atrial cardiac muscle cell signaling relationship: BFO:0000066 CL:1000409 ! occurs in myocyte of sinoatrial node property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4895 property_value: RO:0002161 NCBITaxon:4932 creation_date: 2011-11-10T08:50:15Z [Term] id: GO:0086016 name: AV node cell action potential namespace: biological_process def: "An action potential that occurs in an atrioventricular node cardiac muscle cell." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] synonym: "atrioventricular node cardiac muscle cell action potential" EXACT [] synonym: "AV node cardiac muscle cell action potential" EXACT [] is_a: GO:0086001 ! cardiac muscle cell action potential intersection_of: GO:0001508 ! action potential intersection_of: BFO:0000066 CL:1000410 ! occurs in myocyte of atrioventricular node relationship: BFO:0000050 GO:0086027 ! part of AV node cell to bundle of His cell signaling relationship: BFO:0000066 CL:1000410 ! occurs in myocyte of atrioventricular node property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4895 property_value: RO:0002161 NCBITaxon:4932 creation_date: 2011-11-10T08:58:56Z [Term] id: GO:0086017 name: Purkinje myocyte action potential namespace: biological_process def: "An action potential that occurs in a Purkinje myocyte." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] is_a: GO:0086001 ! cardiac muscle cell action potential intersection_of: GO:0001508 ! action potential intersection_of: BFO:0000066 CL:0002068 ! occurs in Purkinje myocyte relationship: BFO:0000050 GO:0086029 ! part of Purkinje myocyte to ventricular cardiac muscle cell signaling relationship: BFO:0000066 CL:0002068 ! occurs in Purkinje myocyte property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4895 property_value: RO:0002161 NCBITaxon:4932 creation_date: 2011-11-10T08:58:56Z [Term] id: GO:0086018 name: SA node cell to atrial cardiac muscle cell signaling namespace: biological_process def: "Any process that mediates the transfer of information from an SA node cardiomyocyte to an atrial cardiomyocyte." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] synonym: "SA node cardiac muscle cell to atrial cardiac muscle cell signalling" EXACT [] synonym: "SA node cardiomyocyte to atrial cardiomyocyte signalling" EXACT [] synonym: "SAN cardiomyocyte to atrial cardiomyocyte signalling" EXACT [] synonym: "sinoatrial node cardiomyocyte to atrial cardiomyocyte signalling" EXACT [] synonym: "sinus node cardiomyocyte to atrial cardiomyocyte signalling" NARROW [] is_a: GO:0086019 ! cell-cell signaling involved in cardiac conduction is_a: GO:0086070 ! SA node cell to atrial cardiac muscle cell communication property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 creation_date: 2011-11-10T09:15:01Z [Term] id: GO:0086019 name: cell-cell signaling involved in cardiac conduction namespace: biological_process def: "Any process that mediates the transfer of information from one cell to another and contributes to the heart process that regulates cardiac muscle contraction; beginning with the generation of an action potential in the sinoatrial node and ending with regulation of contraction of the myocardium." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] synonym: "cell-cell signalling involved in cardiac conduction" EXACT [GOC:mah] is_a: GO:0007267 ! cell-cell signaling is_a: GO:0086065 ! cell communication involved in cardiac conduction intersection_of: GO:0007267 ! cell-cell signaling intersection_of: BFO:0000050 GO:0061337 ! part of cardiac conduction property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 creation_date: 2011-11-16T03:43:52Z [Term] id: GO:0086026 name: atrial cardiac muscle cell to AV node cell signaling namespace: biological_process def: "Any process that mediates the transfer of information from an atrial cardiomyocyte to an AV node cell." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] synonym: "atrial cardiomyocyte to atrioventricular node cell signaling" EXACT [] synonym: "atrial cardiomyocyte to AV node cell signaling" EXACT [] synonym: "atrial cardiomyocyte to AV node cell signalling" EXACT [GOC:mah] is_a: GO:0086019 ! cell-cell signaling involved in cardiac conduction is_a: GO:0086066 ! atrial cardiac muscle cell to AV node cell communication property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 creation_date: 2011-11-11T02:02:14Z [Term] id: GO:0086027 name: AV node cell to bundle of His cell signaling namespace: biological_process def: "Any process that mediates the transfer of information from an AV node cardiac muscle cell to a bundle of His cardiomyocyte." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] synonym: "atrioventricular node to bundle of His cell signaling" EXACT [] synonym: "AV node cell to bundle of His cell signalling" EXACT [GOC:mah] is_a: GO:0086019 ! cell-cell signaling involved in cardiac conduction is_a: GO:0086067 ! AV node cell to bundle of His cell communication property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 creation_date: 2011-11-11T02:02:14Z [Term] id: GO:0086028 name: bundle of His cell to Purkinje myocyte signaling namespace: biological_process def: "Any process that mediates the transfer of information from a bundle of His cardiomyocyte to a Purkinje myocyte." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] synonym: "bundle of His cardiac muscle cell to Purkinje myocyte signaling" EXACT [] synonym: "bundle of His cardiac muscle cell to Purkinje myocyte signalling" EXACT [GOC:mah] is_a: GO:0086019 ! cell-cell signaling involved in cardiac conduction is_a: GO:0086069 ! bundle of His cell to Purkinje myocyte communication property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 creation_date: 2011-11-11T02:02:14Z [Term] id: GO:0086029 name: Purkinje myocyte to ventricular cardiac muscle cell signaling namespace: biological_process def: "Any process that mediates the transfer of information from a Purkinje myocyte to a ventricular cardiac muscle cell." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] synonym: "Purkinje myocyte to ventricular cardiac muscle cell signalling" EXACT [GOC:mah] is_a: GO:0086019 ! cell-cell signaling involved in cardiac conduction is_a: GO:0086068 ! Purkinje myocyte to ventricular cardiac muscle cell communication intersection_of: GO:0007267 ! cell-cell signaling intersection_of: RO:0002231 CL:0002068 ! has start location Purkinje myocyte intersection_of: RO:0002232 CL:2000046 ! has end location ventricular cardiac muscle cell relationship: RO:0002231 CL:0002068 ! has start location Purkinje myocyte relationship: RO:0002232 CL:2000046 ! has end location ventricular cardiac muscle cell property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 creation_date: 2011-11-11T02:02:14Z [Term] id: GO:0086041 name: voltage-gated potassium channel activity involved in SA node cell action potential depolarization namespace: molecular_function def: "Enables the transmembrane transfer of a potassium ion by a voltage-gated channel through the plasma membrane of an SA node cardiac muscle cell contributing to the depolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] synonym: "voltage-gated potassium channel activity involved in SAN cell action potential depolarization" EXACT [] synonym: "voltage-gated potassium channel activity involved in sinoatrial node cell action potential depolarization" EXACT [] synonym: "voltage-gated potassium channel activity involved in sinus node cell action potential depolarization" NARROW [] is_a: GO:0005249 ! voltage-gated potassium channel activity intersection_of: GO:0005267 ! potassium channel activity intersection_of: BFO:0000050 GO:0086046 ! part of membrane depolarization during SA node cell action potential relationship: BFO:0000050 GO:0086046 ! part of membrane depolarization during SA node cell action potential property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4895 property_value: RO:0002161 NCBITaxon:4932 creation_date: 2011-11-11T03:37:42Z [Term] id: GO:0086043 name: bundle of His cell action potential namespace: biological_process def: "An action potential that occurs in a bundle of His cell." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] synonym: "bundle of His cardiac muscle cell action potential" EXACT [] is_a: GO:0086001 ! cardiac muscle cell action potential intersection_of: GO:0001508 ! action potential intersection_of: BFO:0000066 CL:0010005 ! occurs in atrioventricular bundle cell relationship: BFO:0000050 GO:0086028 ! part of bundle of His cell to Purkinje myocyte signaling relationship: BFO:0000066 CL:0010005 ! occurs in atrioventricular bundle cell property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4895 property_value: RO:0002161 NCBITaxon:4932 creation_date: 2011-11-15T12:01:18Z [Term] id: GO:0086045 name: membrane depolarization during AV node cell action potential namespace: biological_process def: "The process in which AV node cardiac muscle cell membrane potential changes in the depolarizing direction from the negative resting potential towards the positive membrane potential that will be the peak of the action potential." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] synonym: "membrane depolarization during atrioventricular node cardiac muscle cell action potential" EXACT [] synonym: "membrane depolarization during AV node cardiac muscle cell action potential" EXACT [] is_a: GO:0086012 ! membrane depolarization during cardiac muscle cell action potential intersection_of: GO:0051899 ! membrane depolarization intersection_of: BFO:0000050 GO:0086016 ! part of AV node cell action potential relationship: BFO:0000050 GO:0086016 ! part of AV node cell action potential property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4895 property_value: RO:0002161 NCBITaxon:4932 creation_date: 2011-11-16T10:45:18Z [Term] id: GO:0086046 name: membrane depolarization during SA node cell action potential namespace: biological_process def: "The process in which SA node cardiac muscle cell membrane potential changes in the depolarizing direction from the negative resting potential towards the positive membrane potential that will be the peak of the action potential." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] synonym: "membrane depolarization involved in regulation of SA node cardiac muscle cell action potential" EXACT [] synonym: "membrane depolarization involved in regulation of SAN cardiac muscle cell action potential" EXACT [] synonym: "membrane depolarization involved in regulation of sinoatrial node cardiac muscle cell action potential" EXACT [] synonym: "membrane depolarization involved in regulation of sinus node cardiac muscle cell action potential" NARROW [] is_a: GO:0086012 ! membrane depolarization during cardiac muscle cell action potential intersection_of: GO:0051899 ! membrane depolarization intersection_of: BFO:0000050 GO:0086015 ! part of SA node cell action potential relationship: BFO:0000050 GO:0086015 ! part of SA node cell action potential property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4895 property_value: RO:0002161 NCBITaxon:4932 creation_date: 2011-11-16T10:52:57Z [Term] id: GO:0086047 name: membrane depolarization during Purkinje myocyte cell action potential namespace: biological_process def: "The process in which Purkinje myocyte membrane potential changes in the depolarizing direction from the negative resting potential towards the positive membrane potential that will be the peak of the action potential." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] is_a: GO:0086012 ! membrane depolarization during cardiac muscle cell action potential intersection_of: GO:0051899 ! membrane depolarization intersection_of: BFO:0000050 GO:0086017 ! part of Purkinje myocyte action potential relationship: BFO:0000050 GO:0086017 ! part of Purkinje myocyte action potential property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4895 property_value: RO:0002161 NCBITaxon:4932 creation_date: 2011-11-16T10:54:47Z [Term] id: GO:0086048 name: membrane depolarization during bundle of His cell action potential namespace: biological_process def: "The process in which bundle of His cardiac muscle cell membrane potential changes in the depolarizing direction from the negative resting potential towards the positive membrane potential that will be the peak of the action potential." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] synonym: "membrane depolarization during bundle of His cardiac muscle cell action potential" EXACT [] is_a: GO:0086012 ! membrane depolarization during cardiac muscle cell action potential intersection_of: GO:0051899 ! membrane depolarization intersection_of: BFO:0000050 GO:0086043 ! part of bundle of His cell action potential relationship: BFO:0000050 GO:0086043 ! part of bundle of His cell action potential property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4895 property_value: RO:0002161 NCBITaxon:4932 creation_date: 2011-11-16T10:56:26Z [Term] id: GO:0086049 name: membrane repolarization during AV node cell action potential namespace: biological_process def: "The process in which ions are transported across a membrane such that the AV node cardiac muscle cell membrane potential changes in the direction from the positive membrane potential at the peak of the action potential towards the negative resting potential." [GOC:BHF, GOC:dph, GOC:mtg_cardiac_conduct_nov11] synonym: "membrane repolarization involved in regulation of atrioventricular node cardiac muscle cell action potential" EXACT [] synonym: "membrane repolarization involved in regulation of AV node cardiac muscle cell action potential" EXACT [] is_a: GO:0086013 ! membrane repolarization during cardiac muscle cell action potential intersection_of: GO:0086009 ! membrane repolarization intersection_of: BFO:0000050 GO:0086016 ! part of AV node cell action potential relationship: BFO:0000050 GO:0086016 ! part of AV node cell action potential creation_date: 2011-11-16T11:43:38Z [Term] id: GO:0086050 name: membrane repolarization during bundle of His cell action potential namespace: biological_process def: "The process in which ions are transported across a membrane such that the bundle of His cardiac muscle cell membrane potential changes in the direction from the positive membrane potential at the peak of the action potential towards the negative resting potential." [GOC:BHF, GOC:dph, GOC:mtg_cardiac_conduct_nov11] synonym: "membrane repolarization during bundle of His cardiac muscle cell action potential" EXACT [] is_a: GO:0086013 ! membrane repolarization during cardiac muscle cell action potential intersection_of: GO:0086009 ! membrane repolarization intersection_of: BFO:0000050 GO:0086043 ! part of bundle of His cell action potential relationship: BFO:0000050 GO:0086043 ! part of bundle of His cell action potential creation_date: 2011-11-16T11:50:41Z [Term] id: GO:0086051 name: membrane repolarization during Purkinje myocyte action potential namespace: biological_process def: "The process in which ions are transported across a membrane such that the Purkinje myocyte membrane potential changes in the direction from the positive membrane potential at the peak of the action potential towards the negative resting potential." [GOC:BHF, GOC:dph, GOC:mtg_cardiac_conduct_nov11] is_a: GO:0086013 ! membrane repolarization during cardiac muscle cell action potential intersection_of: GO:0086009 ! membrane repolarization intersection_of: BFO:0000050 GO:0086017 ! part of Purkinje myocyte action potential relationship: BFO:0000050 GO:0086017 ! part of Purkinje myocyte action potential creation_date: 2011-11-16T11:51:56Z [Term] id: GO:0086052 name: membrane repolarization during SA node cell action potential namespace: biological_process def: "The process in which an SA node cardiac muscle cell membrane potential changes in the direction from the positive membrane potential at the peak of the action potential towards the negative resting potential." [GOC:BHF, GOC:dph, GOC:mtg_cardiac_conduct_nov11] synonym: "membrane repolarization involved in regulation of SA node cardiac muscle cell action potential" EXACT [] synonym: "membrane repolarization involved in regulation of SAN cardiac muscle cell action potential" EXACT [] synonym: "membrane repolarization involved in regulation of sinoatrial node cardiac muscle cell action potential" EXACT [] synonym: "membrane repolarization involved in regulation of sinus node cardiac muscle cell action potential" NARROW [] is_a: GO:0086013 ! membrane repolarization during cardiac muscle cell action potential intersection_of: GO:0086009 ! membrane repolarization intersection_of: BFO:0000050 GO:0086015 ! part of SA node cell action potential relationship: BFO:0000050 GO:0086015 ! part of SA node cell action potential creation_date: 2011-11-16T11:54:12Z [Term] id: GO:0086056 name: voltage-gated calcium channel activity involved in AV node cell action potential namespace: molecular_function def: "Enables the transmembrane transfer of a calcium ion by a voltage-gated channel across the plasma membrane of an AV node cardiac muscle cell that contributes to the depolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] synonym: "voltage-gated calcium channel activity involved in atrioventricular node cardiac muscle cell action potential" EXACT [] synonym: "voltage-gated calcium channel activity involved in AV node cardiac muscle cell action potential" EXACT [] is_a: GO:0086007 ! voltage-gated calcium channel activity involved in cardiac muscle cell action potential intersection_of: GO:0005245 ! voltage-gated calcium channel activity intersection_of: BFO:0000050 GO:0086016 ! part of AV node cell action potential relationship: BFO:0000050 GO:0086045 ! part of membrane depolarization during AV node cell action potential property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4895 property_value: RO:0002161 NCBITaxon:4932 creation_date: 2011-11-17T12:24:22Z [Term] id: GO:0086057 name: voltage-gated calcium channel activity involved in bundle of His cell action potential namespace: molecular_function def: "Enables the transmembrane transfer of a calcium ion by a voltage-gated channel across the plasma membrane of a bundle of His cardiac muscle cell that contributes to the depolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] synonym: "voltage-gated calcium channel activity involved in bundle of His cardiac muscle cell action potential" EXACT [] is_a: GO:0086007 ! voltage-gated calcium channel activity involved in cardiac muscle cell action potential intersection_of: GO:0005245 ! voltage-gated calcium channel activity intersection_of: BFO:0000050 GO:0086043 ! part of bundle of His cell action potential relationship: BFO:0000050 GO:0086048 ! part of membrane depolarization during bundle of His cell action potential property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4895 property_value: RO:0002161 NCBITaxon:4932 creation_date: 2011-11-17T12:32:51Z [Term] id: GO:0086058 name: voltage-gated calcium channel activity involved in Purkinje myocyte cell action potential namespace: molecular_function def: "Enables the transmembrane transfer of a calcium ion by a voltage-gated channel across the plasma membrane of an Purkinje myocyte cell that contributes to the depolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] is_a: GO:0086007 ! voltage-gated calcium channel activity involved in cardiac muscle cell action potential intersection_of: GO:0005245 ! voltage-gated calcium channel activity intersection_of: BFO:0000050 GO:0086017 ! part of Purkinje myocyte action potential relationship: BFO:0000050 GO:0086047 ! part of membrane depolarization during Purkinje myocyte cell action potential property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4895 property_value: RO:0002161 NCBITaxon:4932 creation_date: 2011-11-17T12:35:02Z [Term] id: GO:0086059 name: voltage-gated calcium channel activity involved SA node cell action potential namespace: molecular_function def: "Enables the transmembrane transfer of a calcium ion by a voltage-gated channel across the plasma membrane of an SA node cardiac muscle cell that contributes to the depolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] synonym: "voltage-gated calcium channel activity involved in SA node cardiac muscle cell action potential" EXACT [] synonym: "voltage-gated calcium channel activity involved in SAN cardiac muscle cell action potential" EXACT [] synonym: "voltage-gated calcium channel activity involved in sinoatrial node cardiac muscle cell action potential" EXACT [] synonym: "voltage-gated calcium channel activity involved in sinus node cardiac muscle cell action potential" NARROW [] is_a: GO:0086007 ! voltage-gated calcium channel activity involved in cardiac muscle cell action potential intersection_of: GO:0005245 ! voltage-gated calcium channel activity intersection_of: BFO:0000050 GO:0086015 ! part of SA node cell action potential relationship: BFO:0000050 GO:0086046 ! part of membrane depolarization during SA node cell action potential property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4895 property_value: RO:0002161 NCBITaxon:4932 creation_date: 2011-11-17T12:39:27Z [Term] id: GO:0086060 name: voltage-gated sodium channel activity involved in AV node cell action potential namespace: molecular_function def: "Enables the transmembrane transfer of a sodium ion by a voltage-gated channel through the plasma membrane of an AV node cardiac muscle cell contributing to the depolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] synonym: "voltage-gated sodium channel activity involved in atrioventricular node cardiac muscle cell action potential" EXACT [] synonym: "voltage-gated sodium channel activity involved in AV node cardiac muscle cell action potential" EXACT [] is_a: GO:0086006 ! voltage-gated sodium channel activity involved in cardiac muscle cell action potential intersection_of: GO:0005248 ! voltage-gated sodium channel activity intersection_of: BFO:0000050 GO:0086016 ! part of AV node cell action potential relationship: BFO:0000050 GO:0086045 ! part of membrane depolarization during AV node cell action potential property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4895 property_value: RO:0002161 NCBITaxon:4932 creation_date: 2011-11-17T12:52:48Z [Term] id: GO:0086061 name: voltage-gated sodium channel activity involved in bundle of His cell action potential namespace: molecular_function def: "Enables the transmembrane transfer of a sodium ion by a voltage-gated channel through the plasma membrane of a bundle of His cardiac muscle cell contributing to the depolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] synonym: "voltage-gated sodium channel activity involved in bundle of His cardiac muscle cell action potential" EXACT [] is_a: GO:0086006 ! voltage-gated sodium channel activity involved in cardiac muscle cell action potential intersection_of: GO:0005248 ! voltage-gated sodium channel activity intersection_of: BFO:0000050 GO:0086043 ! part of bundle of His cell action potential relationship: BFO:0000050 GO:0086048 ! part of membrane depolarization during bundle of His cell action potential property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4895 property_value: RO:0002161 NCBITaxon:4932 creation_date: 2011-11-17T12:58:13Z [Term] id: GO:0086062 name: voltage-gated sodium channel activity involved in Purkinje myocyte action potential namespace: molecular_function def: "Enables the transmembrane transfer of a sodium ion by a voltage-gated channel through the plasma membrane of a Purkinje myocyte contributing to the depolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] is_a: GO:0086006 ! voltage-gated sodium channel activity involved in cardiac muscle cell action potential intersection_of: GO:0005248 ! voltage-gated sodium channel activity intersection_of: BFO:0000050 GO:0086017 ! part of Purkinje myocyte action potential relationship: BFO:0000050 GO:0086047 ! part of membrane depolarization during Purkinje myocyte cell action potential property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4895 property_value: RO:0002161 NCBITaxon:4932 creation_date: 2011-11-17T01:50:43Z [Term] id: GO:0086063 name: voltage-gated sodium channel activity involved in SA node cell action potential namespace: molecular_function def: "Enables the transmembrane transfer of a sodium ion by a voltage-gated channel through the plasma membrane of an SA node cardiac muscle cell contributing to the depolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] synonym: "voltage-gated sodium channel activity involved in SA node cardiac muscle cell action potential" EXACT [] synonym: "voltage-gated sodium channel activity involved in SAN cardiac muscle cell action potential" EXACT [] synonym: "voltage-gated sodium channel activity involved in sinoatrial node cardiac muscle cell action potential" EXACT [] synonym: "voltage-gated sodium channel activity involved in sinus node cardiac muscle cell action potential" NARROW [] is_a: GO:0086006 ! voltage-gated sodium channel activity involved in cardiac muscle cell action potential intersection_of: GO:0005248 ! voltage-gated sodium channel activity intersection_of: BFO:0000050 GO:0086015 ! part of SA node cell action potential relationship: BFO:0000050 GO:0086046 ! part of membrane depolarization during SA node cell action potential property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4895 property_value: RO:0002161 NCBITaxon:4932 creation_date: 2011-11-17T01:53:08Z [Term] id: GO:0086065 name: cell communication involved in cardiac conduction namespace: biological_process def: "Any process that mediates interactions between a cell and its surroundings that contributes to the process of cardiac conduction. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] is_a: BFO:0000003 is_a: GO:0007154 ! cell communication intersection_of: GO:0007154 ! cell communication intersection_of: BFO:0000050 GO:0061337 ! part of cardiac conduction relationship: BFO:0000050 GO:0061337 ! part of cardiac conduction property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 creation_date: 2011-11-22T08:57:02Z [Term] id: GO:0086066 name: atrial cardiac muscle cell to AV node cell communication namespace: biological_process def: "The process that mediates interactions between an atrial cardiomyocyte and its surroundings that contributes to the process of the atrial cardiomyocyte communicating with an AV node cell in cardiac conduction. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] synonym: "atrial cardiomyocyte to atrioventricular node cell communication" EXACT [] synonym: "atrial cardiomyocyte to AV node cell communication" EXACT [] is_a: GO:0086065 ! cell communication involved in cardiac conduction property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 creation_date: 2011-11-22T09:05:09Z [Term] id: GO:0086067 name: AV node cell to bundle of His cell communication namespace: biological_process def: "The process that mediates interactions between an AV node cell and its surroundings that contributes to the process of the AV node cell communicating with a bundle of His cell in cardiac conduction. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] synonym: "atrioventricular node cell to bundle of His cell communication" EXACT [] is_a: GO:0086065 ! cell communication involved in cardiac conduction property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 creation_date: 2011-11-22T09:11:44Z [Term] id: GO:0086068 name: Purkinje myocyte to ventricular cardiac muscle cell communication namespace: biological_process def: "The process that mediates interactions between a Purkinje myocyte and its surroundings that contributes to the process of the Purkinje myocyte communicating with a ventricular cardiac muscle cell in cardiac conduction. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] is_a: GO:0086065 ! cell communication involved in cardiac conduction property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 creation_date: 2011-11-22T09:14:49Z [Term] id: GO:0086069 name: bundle of His cell to Purkinje myocyte communication namespace: biological_process def: "The process that mediates interactions between a bundle of His cell and its surroundings that contributes to the process of the bundle of His cell communicating with a Purkinje myocyte in cardiac conduction. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] synonym: "atrioventricular junction myocyte to bundle branch myocyte" NARROW [] synonym: "bundle branch myocyte to Purkinje myocyte communication" NARROW [] synonym: "bundle of His cardiac muscle cell to Purkinje myocyte communication" EXACT [] synonym: "bundle of His myocyte to atrioventricular junction myocyte" NARROW [] synonym: "ventricular conduction system cell to cell communication" EXACT [] is_a: GO:0086065 ! cell communication involved in cardiac conduction property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/20731" xsd:anyURI property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 creation_date: 2011-11-22T09:18:49Z [Term] id: GO:0086070 name: SA node cell to atrial cardiac muscle cell communication namespace: biological_process def: "The process that mediates interactions between an SA node cardiomyocyte and its surroundings that contributes to the process of the SA node cardiomyocyte communicating with an atrial cardiomyocyte in cardiac conduction. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] synonym: "SA node cardiac muscle cell to atrial cardiac muscle cell communication" EXACT [] synonym: "SA node cardiomyocyte to atrial cardiomyocyte communication" EXACT [] synonym: "SAN cardiomyocyte to atrial cardiomyocyte communication" EXACT [] synonym: "sinoatrial node cardiomyocyte to atrial cardiomyocyte communication" EXACT [] synonym: "sinus node cardiomyocyte to atrial cardiomyocyte communication" NARROW [] is_a: GO:0086065 ! cell communication involved in cardiac conduction property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 creation_date: 2011-11-22T09:32:45Z [Term] id: GO:0086086 name: voltage-gated potassium channel activity involved in AV node cell action potential repolarization namespace: molecular_function def: "Catalysis of the transmembrane transfer of a potassium ion by a voltage-gated channel through the plasma membrane of an AV node cardiac muscle cell contributing to the repolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] synonym: "voltage-gated potassium channel activity involved in atrioventricular node cardiac muscle cell action potential" EXACT [] synonym: "voltage-gated potassium channel activity involved in AV node cardiac muscle cell action potential repolarization" EXACT [] is_a: GO:0086008 ! voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization intersection_of: GO:0005249 ! voltage-gated potassium channel activity intersection_of: BFO:0000050 GO:0086016 ! part of AV node cell action potential intersection_of: RO:0004009 CHEBI:29103 ! has primary input relationship: BFO:0000050 GO:0086049 ! part of membrane repolarization during AV node cell action potential creation_date: 2011-11-22T01:26:32Z [Term] id: GO:0086087 name: voltage-gated potassium channel activity involved in bundle of His cell action potential repolarization namespace: molecular_function def: "Enables the transmembrane transfer of a potassium ion by a voltage-gated channel through the plasma membrane of a bundle of His cell contributing to the repolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] is_a: GO:0086008 ! voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization intersection_of: GO:0022832 ! voltage-gated channel activity intersection_of: BFO:0000050 GO:0086043 ! part of bundle of His cell action potential intersection_of: RO:0004009 CHEBI:29103 ! has primary input relationship: BFO:0000050 GO:0086050 ! part of membrane repolarization during bundle of His cell action potential creation_date: 2011-11-22T01:30:20Z [Term] id: GO:0086088 name: voltage-gated potassium channel activity involved in Purkinje myocyte action potential repolarization namespace: molecular_function def: "Enables the transmembrane transfer of a potassium ion by a voltage-gated channel through the plasma membrane of a Purkinje myocyte contributing to the repolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] is_a: GO:0086008 ! voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization intersection_of: GO:0022832 ! voltage-gated channel activity intersection_of: BFO:0000050 GO:0086017 ! part of Purkinje myocyte action potential intersection_of: RO:0004009 CHEBI:29103 ! has primary input relationship: BFO:0000050 GO:0086051 ! part of membrane repolarization during Purkinje myocyte action potential creation_date: 2011-11-22T01:32:02Z [Term] id: GO:0086089 name: voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization namespace: molecular_function def: "Enables the transmembrane transfer of a potassium ion by a voltage-gated channel through the plasma membrane of an atrial cardiomyocyte contributing to the repolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] synonym: "voltage-gated potassium channel activity involved in atrial cardiomyocyte action potential repolarization" EXACT [] is_a: GO:0086008 ! voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization intersection_of: GO:0022832 ! voltage-gated channel activity intersection_of: BFO:0000050 GO:0086014 ! part of atrial cardiac muscle cell action potential intersection_of: RO:0004009 CHEBI:29103 ! has primary input relationship: BFO:0000050 GO:0086014 ! part of atrial cardiac muscle cell action potential creation_date: 2011-11-22T01:33:01Z [Term] id: GO:0086090 name: voltage-gated potassium channel activity involved in SA node cell action potential repolarization namespace: molecular_function def: "Enables the transmembrane transfer of a potassium ion by a voltage-gated channel through the plasma membrane of an SA node cell contributing to the repolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] synonym: "voltage-gated potassium channel activity involved in SAN cell action potential" EXACT [] synonym: "voltage-gated potassium channel activity involved in sinoatrial node cell action potential" EXACT [] synonym: "voltage-gated potassium channel activity involved in sinus node cell action potential" NARROW [] is_a: GO:0086008 ! voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization intersection_of: GO:0022832 ! voltage-gated channel activity intersection_of: BFO:0000050 GO:0086052 ! part of membrane repolarization during SA node cell action potential intersection_of: RO:0004009 CHEBI:29103 ! has primary input relationship: BFO:0000050 GO:0086052 ! part of membrane repolarization during SA node cell action potential creation_date: 2011-11-22T01:38:08Z [Term] id: GO:0086093 name: G protein-coupled acetylcholine receptor signaling pathway involved in heart process namespace: biological_process def: "A G protein-coupled acetylcholine receptor signaling pathway, which contributes to a circulatory system process carried out by the heart." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] synonym: "G-protein coupled acetylcholine receptor signaling pathway involved in heart process" EXACT [] synonym: "G-protein coupled acetylcholine receptor signalling pathway involved in heart process" EXACT [GOC:bf] synonym: "M2 receptor signaling pathway involved in heart process" NARROW [GOC:mtg_cardiac_conduct_nov11] synonym: "muscarinic receptor signaling pathway involved in heart process" RELATED [GOC:mtg_cardiac_conduct_nov11] is_a: GO:0007213 ! G protein-coupled acetylcholine receptor signaling pathway is_a: GO:0086103 ! G protein-coupled receptor signaling pathway involved in heart process intersection_of: GO:0007213 ! G protein-coupled acetylcholine receptor signaling pathway intersection_of: BFO:0000050 GO:0003015 ! part of heart process [Term] id: GO:0086103 name: G protein-coupled receptor signaling pathway involved in heart process namespace: biological_process def: "An G protein-coupled receptor signaling pathway which contributes to a circulatory system process carried out by the heart." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11, PMID:17376402] synonym: "G-protein coupled receptor signaling pathway involved in heart process" EXACT [GOC:bf] synonym: "G-protein coupled receptor signalling pathway involved in heart process" EXACT [GOC:bf] synonym: "GPCR signaling pathway involved in cardiac process" EXACT [GOC:bf] synonym: "GPCR signaling pathway involved in heart process" EXACT [GOC:bf] is_a: GO:0007186 ! G protein-coupled receptor signaling pathway intersection_of: GO:0007186 ! G protein-coupled receptor signaling pathway intersection_of: BFO:0000050 GO:0003015 ! part of heart process relationship: BFO:0000050 GO:0003015 ! part of heart process property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 creation_date: 2012-03-19T01:28:23Z [Term] id: GO:0089704 name: L-glutamate transmembrane export from vacuole namespace: biological_process def: "The directed movement of L-glutamate out of the vacuole, across the vacuolar membrane." [PMID:21307582] is_a: GO:0015813 ! L-glutamate transmembrane transport is_a: GO:0032974 ! amino acid transmembrane export from vacuole intersection_of: GO:0055085 ! transmembrane transport intersection_of: RO:0002338 GO:0005775 ! has target start location vacuolar lumen intersection_of: RO:0002339 GO:0005829 ! has target end location cytosol intersection_of: RO:0004009 CHEBI:29985 ! has primary input [Term] id: GO:0089708 name: L-histidine transmembrane export from vacuole namespace: biological_process def: "The directed movement of L-histidine out of the vacuole, across the vacuolar membrane." [PMID:21307582] is_a: GO:0032974 ! amino acid transmembrane export from vacuole is_a: GO:0089709 ! L-histidine transmembrane transport is_a: GO:1902024 ! L-histidine transport is_a: GO:1990822 ! basic amino acid transmembrane transport intersection_of: GO:0015802 ! basic amino acid transport intersection_of: RO:0002338 GO:0005775 ! has target start location vacuolar lumen intersection_of: RO:0002339 GO:0005829 ! has target end location cytosol intersection_of: RO:0002342 GO:0016020 ! results in transport across membrane intersection_of: RO:0004009 CHEBI:57595 ! has primary input [Term] id: GO:0089709 name: L-histidine transmembrane transport namespace: biological_process def: "The directed movement of L-histidine across a membrane." [PMID:21307582] is_a: GO:0015695 ! organic cation transport is_a: GO:0015801 ! aromatic amino acid transport is_a: GO:0045117 ! azole transmembrane transport is_a: GO:1902475 ! L-alpha-amino acid transmembrane transport intersection_of: GO:0055085 ! transmembrane transport intersection_of: RO:0004009 CHEBI:57595 ! has primary input relationship: RO:0004009 CHEBI:57595 ! has primary input [Term] id: GO:0089718 name: amino acid import across plasma membrane namespace: biological_process def: "The directed movement of an amino acid from outside of a cell, across the plasma membrane and into the cytosol." [GOC:krc, PMID:8195186] synonym: "amino acid import into cell" EXACT [] synonym: "amino acid transmembrane import" BROAD [] synonym: "L-amino acid import" BROAD [] synonym: "L-amino acid uptake" NARROW [] is_a: GO:0003333 ! amino acid transmembrane transport is_a: GO:0098739 ! import across plasma membrane intersection_of: GO:0006810 ! transport intersection_of: RO:0002338 GO:0005576 ! has target start location extracellular region intersection_of: RO:0002339 GO:0005829 ! has target end location cytosol intersection_of: RO:0002342 GO:0005886 ! results in transport across plasma membrane intersection_of: RO:0004009 CHEBI:35238 ! has primary input creation_date: 2012-11-14T14:21:41Z [Term] id: GO:0090009 name: primitive streak formation namespace: biological_process def: "The developmental process pertaining to the initial formation of the primitive streak from unspecified parts. The primitive streak is a ridge of cells running along the midline of the embryo where the mesoderm ingresses. It defines the anterior-posterior axis." [GOC:dph, GOC:sdb_2009, GOC:tb] xref: Reactome:R-HSA-9754189 "Germ layer formation at gastrulation" is_a: BFO:0000003 is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0004341 ! results in formation of anatomical entity primitive streak relationship: BFO:0000050 GO:0001702 ! part of gastrulation with mouth forming second relationship: BFO:0000050 GO:0009948 ! part of anterior/posterior axis specification relationship: RO:0002297 UBERON:0004341 ! results in formation of anatomical entity primitive streak creation_date: 2009-07-29T10:31:31Z [Term] id: GO:0090022 name: regulation of neutrophil chemotaxis namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of neutrophil chemotaxis. Neutrophil chemotaxis is the directed movement of a neutrophil cell, the most numerous polymorphonuclear leukocyte found in the blood, in response to an external stimulus, usually an infection or wounding." [GOC:dph, GOC:tb] is_a: GO:0071622 ! regulation of granulocyte chemotaxis is_a: GO:1902622 ! regulation of neutrophil migration intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0030593 ! regulates neutrophil chemotaxis relationship: RO:0002211 GO:0030593 ! regulates neutrophil chemotaxis creation_date: 2009-08-03T10:09:34Z [Term] id: GO:0090023 name: positive regulation of neutrophil chemotaxis namespace: biological_process def: "Any process that increases the frequency, rate, or extent of neutrophil chemotaxis. Neutrophil chemotaxis is the directed movement of a neutrophil cell, the most numerous polymorphonuclear leukocyte found in the blood, in response to an external stimulus, usually an infection or wounding." [GOC:dph, GOC:tb] is_a: GO:0071624 ! positive regulation of granulocyte chemotaxis is_a: GO:0090022 ! regulation of neutrophil chemotaxis is_a: GO:1902624 ! positive regulation of neutrophil migration intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0030593 ! positively regulates neutrophil chemotaxis relationship: RO:0002213 GO:0030593 ! positively regulates neutrophil chemotaxis creation_date: 2009-08-03T10:12:23Z [Term] id: GO:0090024 name: negative regulation of neutrophil chemotaxis namespace: biological_process def: "Any process that decreases the frequency, rate, or extent of neutrophil chemotaxis. Neutrophil chemotaxis is the directed movement of a neutrophil cell, the most numerous polymorphonuclear leukocyte found in the blood, in response to an external stimulus, usually an infection or wounding." [GOC:dph, GOC:tb] is_a: GO:0071623 ! negative regulation of granulocyte chemotaxis is_a: GO:0090022 ! regulation of neutrophil chemotaxis is_a: GO:1902623 ! negative regulation of neutrophil migration intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0030593 ! negatively regulates neutrophil chemotaxis relationship: RO:0002212 GO:0030593 ! negatively regulates neutrophil chemotaxis creation_date: 2009-08-03T10:13:09Z [Term] id: GO:0090025 name: regulation of monocyte chemotaxis namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of monocyte chemotaxis." [GOC:dph, GOC:tb] is_a: GO:0002688 ! regulation of leukocyte chemotaxis is_a: GO:0071675 ! regulation of mononuclear cell migration intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0002548 ! regulates monocyte chemotaxis relationship: RO:0002211 GO:0002548 ! regulates monocyte chemotaxis creation_date: 2009-08-03T10:17:03Z [Term] id: GO:0090026 name: positive regulation of monocyte chemotaxis namespace: biological_process def: "Any process that increases the frequency, rate, or extent of monocyte chemotaxis." [GOC:dph, GOC:tb] is_a: GO:0002690 ! positive regulation of leukocyte chemotaxis is_a: GO:0071677 ! positive regulation of mononuclear cell migration is_a: GO:0090025 ! regulation of monocyte chemotaxis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0002548 ! positively regulates monocyte chemotaxis relationship: RO:0002213 GO:0002548 ! positively regulates monocyte chemotaxis creation_date: 2009-08-03T10:18:54Z [Term] id: GO:0090027 name: negative regulation of monocyte chemotaxis namespace: biological_process def: "Any process that decreases the frequency, rate, or extent of monocyte chemotaxis." [GOC:dph, GOC:tb] is_a: GO:0002689 ! negative regulation of leukocyte chemotaxis is_a: GO:0071676 ! negative regulation of mononuclear cell migration is_a: GO:0090025 ! regulation of monocyte chemotaxis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0002548 ! negatively regulates monocyte chemotaxis relationship: RO:0002212 GO:0002548 ! negatively regulates monocyte chemotaxis creation_date: 2009-08-03T10:19:40Z [Term] id: GO:0090030 name: regulation of steroid hormone biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of steroid hormones,compounds with a 1, 2, cyclopentanoperhydrophenanthrene nucleus that act as hormones." [GOC:dph, GOC:tb] is_a: GO:0046885 ! regulation of hormone biosynthetic process is_a: GO:0050810 ! regulation of steroid biosynthetic process property_value: RO:0002161 NCBITaxon:4895 creation_date: 2009-08-03T10:38:27Z [Term] id: GO:0090031 name: positive regulation of steroid hormone biosynthetic process namespace: biological_process def: "Any process that increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of steroid hormones,compounds with a 1, 2, cyclopentanoperhydrophenanthrene nucleus that act as hormones." [GOC:dph, GOC:tb] is_a: GO:0010893 ! positive regulation of steroid biosynthetic process is_a: GO:0046886 ! positive regulation of hormone biosynthetic process is_a: GO:0090030 ! regulation of steroid hormone biosynthetic process property_value: RO:0002161 NCBITaxon:4895 creation_date: 2009-08-03T10:40:32Z [Term] id: GO:0090032 name: negative regulation of steroid hormone biosynthetic process namespace: biological_process def: "Any process that decreases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of steroid hormones,compounds with a 1, 2, cyclopentanoperhydrophenanthrene nucleus that act as hormones." [GOC:dph, GOC:tb] is_a: GO:0010894 ! negative regulation of steroid biosynthetic process is_a: GO:0032353 ! negative regulation of hormone biosynthetic process is_a: GO:0090030 ! regulation of steroid hormone biosynthetic process property_value: RO:0002161 NCBITaxon:4895 creation_date: 2009-08-03T10:41:35Z [Term] id: GO:0090063 name: positive regulation of microtubule nucleation namespace: biological_process def: "Any process that increases the rate, frequency or extent of microtubule nucleation. Microtubule nucleation is the 'de novo' formation of a microtubule, in which tubulin heterodimers form metastable oligomeric aggregates, some of which go on to support formation of a complete microtubule. Microtubule nucleation usually occurs from a specific site within a cell." [GOC:dph, GOC:tb] is_a: GO:0010968 ! regulation of microtubule nucleation is_a: GO:0031116 ! positive regulation of microtubule polymerization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0007020 ! positively regulates microtubule nucleation relationship: RO:0002213 GO:0007020 ! positively regulates microtubule nucleation creation_date: 2009-08-12T11:33:09Z [Term] id: GO:0090066 name: regulation of anatomical structure size namespace: biological_process def: "Any process that modulates the size of an anatomical structure." [GOC:dph, GOC:tb] is_a: GO:0065008 ! regulation of biological quality creation_date: 2009-09-02T11:00:08Z [Term] id: GO:0090068 name: positive regulation of cell cycle process namespace: biological_process def: "Any process that increases the rate, frequency or extent of a cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events." [GOC:dph, GOC:tb] is_a: GO:0010564 ! regulation of cell cycle process is_a: GO:0045787 ! positive regulation of cell cycle intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0022402 ! positively regulates cell cycle process relationship: RO:0002213 GO:0022402 ! positively regulates cell cycle process creation_date: 2009-09-09T11:39:52Z [Term] id: GO:0090069 name: regulation of ribosome biogenesis namespace: biological_process def: "Any process that modulates the rate, frequency or extent of ribosome biogenesis. Ribosome biogenesis is the cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of ribosome subunits." [GOC:dph, GOC:tb] is_a: GO:0044087 ! regulation of cellular component biogenesis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0042254 ! regulates ribosome biogenesis relationship: RO:0002211 GO:0042254 ! regulates ribosome biogenesis creation_date: 2009-09-11T10:32:17Z [Term] id: GO:0090070 name: positive regulation of ribosome biogenesis namespace: biological_process def: "Any process that increases the rate, frequency or extent of ribosome biogenesis. Ribosome biogenesis is the cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of ribosome subunits." [GOC:dph, GOC:tb] is_a: GO:0044089 ! positive regulation of cellular component biogenesis is_a: GO:0090069 ! regulation of ribosome biogenesis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0042254 ! positively regulates ribosome biogenesis relationship: RO:0002213 GO:0042254 ! positively regulates ribosome biogenesis creation_date: 2009-09-11T10:32:17Z [Term] id: GO:0090071 name: negative regulation of ribosome biogenesis namespace: biological_process def: "Any process that decreases the rate, frequency or extent of ribosome biogenesis. Ribosome biogenesis is the cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of ribosome subunits." [GOC:dph, GOC:tb] is_a: GO:0048523 ! negative regulation of cellular process is_a: GO:0090069 ! regulation of ribosome biogenesis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0042254 ! negatively regulates ribosome biogenesis relationship: RO:0002212 GO:0042254 ! negatively regulates ribosome biogenesis creation_date: 2009-09-11T10:32:17Z [Term] id: GO:0090077 name: foam cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires the specialized features of a foam cell. A foam cell is a type of cell containing lipids in small vacuoles and typically seen in atherosclerotic lesions, as well as other conditions." [GOC:add, GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0030154 ! cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000891 ! results in acquisition of features of foam cell relationship: RO:0002315 CL:0000891 ! results in acquisition of features of foam cell creation_date: 2009-09-15T03:46:30Z [Term] id: GO:0090078 name: smooth muscle derived foam cell differentiation namespace: biological_process def: "The process in which a smooth muscle cell acquires the specialized features of a foam cell. A foam cell is a type of cell containing lipids in small vacuoles and typically seen in atherosclerotic lesions, as well as other conditions." [GOC:add, GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0090077 ! foam cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000892 ! results in acquisition of features of smooth muscle cell derived foam cell relationship: RO:0002315 CL:0000892 ! results in acquisition of features of smooth muscle cell derived foam cell creation_date: 2009-09-15T03:48:10Z [Term] id: GO:0090087 name: regulation of peptide transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the directed movement of peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:dph, GOC:tb] is_a: GO:0051049 ! regulation of transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0015833 ! regulates peptide transport relationship: RO:0002211 GO:0015833 ! regulates peptide transport creation_date: 2009-10-23T11:21:38Z [Term] id: GO:0090091 name: positive regulation of extracellular matrix disassembly namespace: biological_process def: "Any process that increases the rate, frequency or extent of extracellular matrix disassembly. Extracellular matrix disassembly is a process that results in the breakdown of the extracellular matrix." [GOC:dph, GOC:tb] is_a: GO:0010715 ! regulation of extracellular matrix disassembly is_a: GO:1903055 ! positive regulation of extracellular matrix organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0022617 ! positively regulates extracellular matrix disassembly relationship: RO:0002213 GO:0022617 ! positively regulates extracellular matrix disassembly creation_date: 2009-11-04T10:03:25Z [Term] id: GO:0090102 name: cochlea development namespace: biological_process def: "The progression of the cochlea over time from its formation to the mature structure. The cochlea is the snail-shaped portion of the inner ear that is responsible for the detection of sound." [GOC:dph, GOC:tb] is_a: GO:0048856 ! anatomical structure development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0001844 ! results in development of cochlea relationship: BFO:0000050 GO:0048839 ! part of inner ear development relationship: RO:0002162 NCBITaxon:7776 ! in taxon Gnathostomata relationship: RO:0002296 UBERON:0001844 ! results in development of cochlea creation_date: 2009-11-18T11:42:15Z [Term] id: GO:0090103 name: cochlea morphogenesis namespace: biological_process def: "The process in which the cochlea is generated and organized." [GOC:dph, GOC:tb] is_a: BFO:0000003 is_a: GO:0048598 ! embryonic morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0001844 ! results in morphogenesis of cochlea relationship: BFO:0000050 GO:0042472 ! part of inner ear morphogenesis relationship: BFO:0000050 GO:0090102 ! part of cochlea development relationship: RO:0002298 UBERON:0001844 ! results in morphogenesis of cochlea creation_date: 2009-11-18T11:45:11Z [Term] id: GO:0090104 name: pancreatic epsilon cell differentiation namespace: biological_process def: "The process in which relatively unspecialized cells acquire specialized structural and functional features of a pancreatic epsilon cell. A pancreatic epsilon cell is a cell in the pancreas that secretes ghrelin." [GOC:dph, GOC:tb] synonym: "pancreatic E cell differentiation" EXACT [] is_a: GO:0035883 ! enteroendocrine cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0005019 ! results in acquisition of features of pancreatic epsilon cell relationship: BFO:0000050 GO:0031018 ! part of endocrine pancreas development relationship: RO:0002315 CL:0005019 ! results in acquisition of features of pancreatic epsilon cell creation_date: 2009-11-18T11:48:52Z [Term] id: GO:0090105 name: pancreatic E cell development namespace: biological_process def: "The process whose specific outcome is the progression of a pancreatic E cell over time, from its formation to the mature structure." [GOC:dph, GOC:tb] is_a: GO:0002064 ! epithelial cell development intersection_of: GO:0048468 ! cell development intersection_of: RO:0002296 CL:0005019 ! results in development of pancreatic epsilon cell relationship: BFO:0000050 GO:0090104 ! part of pancreatic epsilon cell differentiation relationship: RO:0002296 CL:0005019 ! results in development of pancreatic epsilon cell creation_date: 2009-11-18T11:51:00Z [Term] id: GO:0090109 name: regulation of cell-substrate junction assembly namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of cell-substrate junction assembly. Cell-substrate junction assembly is the aggregation, arrangement and bonding together of a set of components to form a junction between a cell and its substrate." [GOC:dph, GOC:tb] is_a: GO:0150116 ! regulation of cell-substrate junction organization is_a: GO:1901888 ! regulation of cell junction assembly intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0007044 ! regulates cell-substrate junction assembly relationship: RO:0002211 GO:0007044 ! regulates cell-substrate junction assembly property_value: RO:0002161 NCBITaxon:4751 creation_date: 2009-11-25T11:00:58Z [Term] id: GO:0090130 name: tissue migration namespace: biological_process def: "The process in which the population of cells that make up a tissue undergo directed movement." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0032501 ! multicellular organismal process property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 creation_date: 2009-12-07T03:13:55Z [Term] id: GO:0090131 name: mesenchyme migration namespace: biological_process def: "The process in which the population of cells that make up a mesenchyme undergo directed movement." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0090130 ! tissue migration relationship: BFO:0000050 GO:0072132 ! part of mesenchyme morphogenesis creation_date: 2009-12-07T03:15:17Z [Term] id: GO:0090132 name: epithelium migration namespace: biological_process def: "The process in which the population of cells that make up an epithelium undergo directed movement." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0090130 ! tissue migration property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 creation_date: 2009-12-07T03:19:34Z [Term] id: GO:0090138 name: regulation of actin cytoskeleton organization by cell-cell adhesion namespace: biological_process def: "Any cell-cell adhesion process that modulates the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins." [GOC:ascb_2009, GOC:dph, GOC:tb] synonym: "regulation of actin cytoskeleton organisation by cell-cell adhesion" EXACT [GOC:mah] is_a: GO:0032956 ! regulation of actin cytoskeleton organization is_a: GO:0098609 ! cell-cell adhesion intersection_of: GO:0098609 ! cell-cell adhesion intersection_of: RO:0002211 GO:0030036 ! regulates actin cytoskeleton organization creation_date: 2009-12-08T02:05:00Z [Term] id: GO:0090139 name: mitochondrial chromosome packaging namespace: biological_process def: "A process in which mitochondrial chromosomal DNA and associated proteins organize into a compact, orderly structure." [GOC:ascb_2009, GOC:dph, GOC:tb] synonym: "mitochondrial DNA packaging" EXACT [] is_a: GO:0051276 ! chromosome organization intersection_of: GO:0051276 ! chromosome organization intersection_of: BFO:0000066 GO:0005739 ! occurs in mitochondrion relationship: BFO:0000066 GO:0005739 ! occurs in mitochondrion relationship: RO:0002162 NCBITaxon:2759 ! in taxon Eukaryota creation_date: 2009-12-08T02:12:19Z [Term] id: GO:0090140 name: regulation of mitochondrial fission namespace: biological_process def: "Any process that modulates the rate, frequency or extent of mitochondrial fission. Mitochondrial fission is the division of a mitochondrion within a cell to form two or more separate mitochondrial compartments." [GOC:ascb_2009, GOC:dph, GOC:tb] synonym: "regulation of mitochondrial division" EXACT [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0010821 ! regulation of mitochondrion organization is_a: GO:0022603 ! regulation of anatomical structure morphogenesis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0000266 ! regulates mitochondrial fission relationship: RO:0002211 GO:0000266 ! regulates mitochondrial fission creation_date: 2009-12-08T02:20:48Z [Term] id: GO:0090141 name: positive regulation of mitochondrial fission namespace: biological_process def: "Any process that increases the rate, frequency or extent of mitochondrial fission. Mitochondrial fission is the division of a mitochondrion within a cell to form two or more separate mitochondrial compartments." [GOC:ascb_2009, GOC:dph, GOC:tb] synonym: "positive regulation of mitochondrial division" EXACT [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0010638 ! positive regulation of organelle organization is_a: GO:0051094 ! positive regulation of developmental process is_a: GO:0090140 ! regulation of mitochondrial fission intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0000266 ! positively regulates mitochondrial fission relationship: RO:0002213 GO:0000266 ! positively regulates mitochondrial fission creation_date: 2009-12-08T02:20:48Z [Term] id: GO:0090150 name: establishment of protein localization to membrane namespace: biological_process def: "The directed movement of a protein to a specific location in a membrane." [GOC:ascb_2009, GOC:dph, GOC:tb] synonym: "establishment of protein localisation in membrane" EXACT [GOC:mah] synonym: "establishment of protein localization in membrane" EXACT [] is_a: GO:0045184 ! establishment of protein localization is_a: GO:0051668 ! localization within membrane intersection_of: GO:0045184 ! establishment of protein localization intersection_of: RO:0002339 GO:0016020 ! has target end location membrane creation_date: 2009-12-08T03:18:51Z [Term] id: GO:0090151 name: establishment of protein localization to mitochondrial membrane namespace: biological_process def: "The directed movement of a protein to a specific location in the mitochondrial membrane." [GOC:ascb_2009, GOC:dph, GOC:tb] synonym: "establishment of protein localisation in mitochondrial membrane" EXACT [GOC:mah] synonym: "establishment of protein localization in mitochondrial membrane" EXACT [] is_a: GO:0007006 ! mitochondrial membrane organization is_a: GO:0051649 ! establishment of localization in cell is_a: GO:0072655 ! establishment of protein localization to mitochondrion is_a: GO:0090150 ! establishment of protein localization to membrane intersection_of: GO:0045184 ! establishment of protein localization intersection_of: RO:0002339 GO:0031966 ! has target end location mitochondrial membrane relationship: RO:0002339 GO:0031966 ! has target end location mitochondrial membrane creation_date: 2009-12-08T03:18:51Z [Term] id: GO:0090152 name: establishment of protein localization to mitochondrial membrane involved in mitochondrial fission namespace: biological_process def: "The directed movement of a protein to a specific location in the mitochondrial membrane that contributes to mitochondrial fission." [GOC:ascb_2009, GOC:dph, GOC:tb] synonym: "establishment of protein localisation in mitochondrial membrane involved in mitochondrial fission" EXACT [GOC:mah] synonym: "establishment of protein localization in mitochondrial membrane involved in mitochondrial fission" EXACT [] is_a: GO:0090151 ! establishment of protein localization to mitochondrial membrane intersection_of: GO:0090151 ! establishment of protein localization to mitochondrial membrane intersection_of: BFO:0000050 GO:0000266 ! part of mitochondrial fission relationship: BFO:0000050 GO:0000266 ! part of mitochondrial fission creation_date: 2009-12-08T03:18:51Z [Term] id: GO:0090153 name: regulation of sphingolipid biosynthetic process namespace: biological_process def: "Any process that modulates the rate, frequency or extent of sphingolipid biosynthesis. Sphingolipid biosynthesis is the chemical reactions and pathways resulting in the formation of sphingolipids, any of a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid)." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0010556 ! regulation of macromolecule biosynthetic process is_a: GO:0044087 ! regulation of cellular component biogenesis is_a: GO:0046890 ! regulation of lipid biosynthetic process is_a: GO:1905038 ! regulation of membrane lipid metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0030148 ! regulates sphingolipid biosynthetic process relationship: RO:0002211 GO:0030148 ! regulates sphingolipid biosynthetic process creation_date: 2009-12-08T03:25:49Z [Term] id: GO:0090154 name: positive regulation of sphingolipid biosynthetic process namespace: biological_process def: "Any process that increases the rate, frequency or extent of sphingolipid biosynthesis. Sphingolipid biosynthesis is the chemical reactions and pathways resulting in the formation of sphingolipids, any of a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid)." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0046889 ! positive regulation of lipid biosynthetic process is_a: GO:0090153 ! regulation of sphingolipid biosynthetic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0030148 ! positively regulates sphingolipid biosynthetic process relationship: RO:0002213 GO:0030148 ! positively regulates sphingolipid biosynthetic process creation_date: 2009-12-08T03:27:33Z [Term] id: GO:0090155 name: negative regulation of sphingolipid biosynthetic process namespace: biological_process def: "Any process that decreases the rate, frequency or extent of sphingolipid biosynthesis. Sphingolipid biosynthesis is the chemical reactions and pathways resulting in the formation of sphingolipids, any of a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid)." [GOC:ascb_2009, GOC:dph, GOC:tb] synonym: "negative regulation of sphingolipid biosynthesis involved in cellular sphingolipid homeostasis" RELATED [] is_a: GO:0051055 ! negative regulation of lipid biosynthetic process is_a: GO:0090153 ! regulation of sphingolipid biosynthetic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0030148 ! negatively regulates sphingolipid biosynthetic process relationship: RO:0002212 GO:0030148 ! negatively regulates sphingolipid biosynthetic process creation_date: 2009-12-08T03:33:39Z [Term] id: GO:0090156 name: intracellular sphingolipid homeostasis namespace: biological_process def: "A homeostatic process involved in the maintenance of a steady state level of sphingolipids within a cell." [GOC:ascb_2009, GOC:dph, GOC:tb] synonym: "cellular sphingolipid homeostasis" EXACT [] is_a: GO:0055082 ! intracellular chemical homeostasis is_a: GO:0055088 ! lipid homeostasis intersection_of: GO:0019725 ! cellular homeostasis intersection_of: RO:0002332 CHEBI:26739 ! regulates levels of relationship: RO:0002332 CHEBI:26739 ! regulates levels of creation_date: 2009-12-08T08:21:36Z [Term] id: GO:0090160 name: Golgi to lysosome transport namespace: biological_process def: "The directed movement of substances from the Golgi to lysosomes." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0006896 ! Golgi to vacuole transport is_a: GO:0007041 ! lysosomal transport is_a: GO:0016482 ! cytosolic transport intersection_of: GO:0016192 ! vesicle-mediated transport intersection_of: BFO:0000066 GO:0005829 ! occurs in cytosol intersection_of: RO:0002338 GO:0005794 ! has target start location Golgi apparatus intersection_of: RO:0002339 GO:0005764 ! has target end location lysosome relationship: RO:0002339 GO:0005764 ! has target end location lysosome property_value: RO:0002161 NCBITaxon:4751 creation_date: 2009-12-08T08:35:13Z [Term] id: GO:0090162 name: establishment of epithelial cell polarity namespace: biological_process def: "The specification and formation of anisotropic intracellular organization of an epithelial cell." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: BFO:0000003 is_a: GO:0030010 ! establishment of cell polarity intersection_of: GO:0030010 ! establishment of cell polarity intersection_of: BFO:0000066 CL:0000066 ! occurs in epithelial cell relationship: BFO:0000066 CL:0000066 ! occurs in epithelial cell creation_date: 2009-12-08T08:58:27Z [Term] id: GO:0090166 name: Golgi disassembly namespace: biological_process def: "A cellular process that results in the breakdown of a Golgi apparatus that contributes to Golgi inheritance." [GOC:ascb_2009, GOC:dph, GOC:tb] synonym: "Golgi apparatus disassembly" EXACT [] is_a: GO:0007030 ! Golgi organization is_a: GO:1903008 ! organelle disassembly intersection_of: GO:0022411 ! cellular component disassembly intersection_of: RO:0002590 GO:0005794 ! results in disassembly of Golgi apparatus relationship: BFO:0000050 GO:0048313 ! part of Golgi inheritance relationship: RO:0002590 GO:0005794 ! results in disassembly of Golgi apparatus creation_date: 2009-12-08T09:15:11Z [Term] id: GO:0090168 name: Golgi reassembly namespace: biological_process def: "The reformation of the Golgi following its breakdown and partitioning contributing to Golgi inheritance." [GOC:ascb_2009, GOC:dph, GOC:tb] synonym: "Golgi apparatus reassembly" EXACT [] is_a: GO:0007030 ! Golgi organization is_a: GO:0022607 ! cellular component assembly relationship: BFO:0000050 GO:0048313 ! part of Golgi inheritance creation_date: 2009-12-08T09:15:11Z [Term] id: GO:0090170 name: regulation of Golgi inheritance namespace: biological_process def: "Any process that modulates the rate, frequency or extent of Golgi inheritance. Golgi inheritance is the partitioning of Golgi apparatus between daughter cells at cell division." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:1903358 ! regulation of Golgi organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0048313 ! regulates Golgi inheritance relationship: RO:0002211 GO:0048313 ! regulates Golgi inheritance creation_date: 2009-12-11T10:21:59Z [Term] id: GO:0090171 name: chondrocyte morphogenesis namespace: biological_process def: "The process in which the structures of a chondrocyte are generated and organized. This process occurs while the initially relatively unspecialized cell is acquiring the specialized features of a chondrocyte." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0000902 ! cell morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002299 CL:0000138 ! results in maturation of chondrocyte relationship: BFO:0000050 GO:0002063 ! part of chondrocyte development relationship: RO:0002299 CL:0000138 ! results in maturation of chondrocyte creation_date: 2009-12-11T10:36:02Z [Term] id: GO:0090174 name: organelle membrane fusion namespace: biological_process def: "The joining of two lipid bilayers to form a single organelle membrane." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0048284 ! organelle fusion is_a: GO:0061025 ! membrane fusion intersection_of: GO:0061025 ! membrane fusion intersection_of: RO:0012008 GO:0031090 ! results in fusion of organelle membrane relationship: RO:0012008 GO:0031090 ! results in fusion of organelle membrane creation_date: 2009-12-11T11:44:58Z [Term] id: GO:0090183 name: regulation of kidney development namespace: biological_process def: "Any process that modulates the rate, frequency or extent of kidney development. Kidney development is the process whose specific outcome is the progression of the kidney over time, from its formation to the mature structure. The kidney is an organ that filters the blood and excretes the end products of body metabolism in the form of urine." [GOC:dph, GOC:tb, GOC:yaf] synonym: "regulation of nephrogenesis" RELATED [GOC:dph, GOC:tb] is_a: GO:0050793 ! regulation of developmental process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0001822 ! regulates kidney development relationship: RO:0002211 GO:0001822 ! regulates kidney development creation_date: 2009-12-18T10:50:56Z [Term] id: GO:0090184 name: positive regulation of kidney development namespace: biological_process def: "Any process that increases the rate, frequency or extent of kidney development. Kidney development is the process whose specific outcome is the progression of the kidney over time, from its formation to the mature structure. The kidney is an organ that filters the blood and excretes the end products of body metabolism in the form of urine." [GOC:dph, GOC:tb, GOC:yaf] synonym: "positive regulation of nephrogenesis" RELATED [GOC:dph, GOC:tb] is_a: GO:0051094 ! positive regulation of developmental process is_a: GO:0051240 ! positive regulation of multicellular organismal process is_a: GO:0090183 ! regulation of kidney development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0001822 ! positively regulates kidney development relationship: RO:0002213 GO:0001822 ! positively regulates kidney development creation_date: 2009-12-18T10:52:01Z [Term] id: GO:0090185 name: negative regulation of kidney development namespace: biological_process def: "Any process that decreases the rate, frequency or extent of kidney development. Kidney development is the process whose specific outcome is the progression of the kidney over time, from its formation to the mature structure. The kidney is an organ that filters the blood and excretes the end products of body metabolism in the form of urine." [GOC:dph, GOC:tb, GOC:yaf] synonym: "negative regulation of nephrogenesis" RELATED [GOC:dph, GOC:tb] is_a: GO:0051093 ! negative regulation of developmental process is_a: GO:0051241 ! negative regulation of multicellular organismal process is_a: GO:0090183 ! regulation of kidney development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0001822 ! negatively regulates kidney development relationship: RO:0002212 GO:0001822 ! negatively regulates kidney development creation_date: 2009-12-18T10:58:45Z [Term] id: GO:0090189 name: regulation of branching involved in ureteric bud morphogenesis namespace: biological_process def: "Any process that modulates the rate, frequency or extent of branching involved in ureteric bud morphogenesis, the process in which the branching structure of the ureteric bud is generated and organized. The ureteric bud is an epithelial tube that grows out from the metanephric duct. The bud elongates and branches to give rise to the ureter and kidney collecting tubules." [GOC:dph, GOC:tb, GOC:yaf] is_a: GO:0060688 ! regulation of morphogenesis of a branching structure is_a: GO:0090183 ! regulation of kidney development is_a: GO:1905330 ! regulation of morphogenesis of an epithelium is_a: GO:2000027 ! regulation of animal organ morphogenesis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0001658 ! regulates branching involved in ureteric bud morphogenesis relationship: RO:0002211 GO:0001658 ! regulates branching involved in ureteric bud morphogenesis creation_date: 2009-12-18T11:11:17Z [Term] id: GO:0090190 name: positive regulation of branching involved in ureteric bud morphogenesis namespace: biological_process def: "Any process that increases the rate, frequency or extent of branching involved in ureteric bud morphogenesis, the process in which the branching structure of the ureteric bud is generated and organized. The ureteric bud is an epithelial tube that grows out from the metanephric duct. The bud elongates and branches to give rise to the ureter and kidney collecting tubules." [GOC:dph, GOC:tb, GOC:yaf] is_a: GO:0051240 ! positive regulation of multicellular organismal process is_a: GO:0090189 ! regulation of branching involved in ureteric bud morphogenesis is_a: GO:1905332 ! positive regulation of morphogenesis of an epithelium intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0001658 ! positively regulates branching involved in ureteric bud morphogenesis relationship: RO:0002213 GO:0001658 ! positively regulates branching involved in ureteric bud morphogenesis creation_date: 2009-12-18T11:11:17Z [Term] id: GO:0090191 name: negative regulation of branching involved in ureteric bud morphogenesis namespace: biological_process def: "Any process that decreases the rate, frequency or extent of branching involved in ureteric bud morphogenesis, the process in which the branching structure of the ureteric bud is generated and organized. The ureteric bud is an epithelial tube that grows out from the metanephric duct. The bud elongates and branches to give rise to the ureter and kidney collecting tubules." [GOC:dph, GOC:tb, GOC:yaf] is_a: GO:0051241 ! negative regulation of multicellular organismal process is_a: GO:0090189 ! regulation of branching involved in ureteric bud morphogenesis is_a: GO:1905331 ! negative regulation of morphogenesis of an epithelium intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0001658 ! negatively regulates branching involved in ureteric bud morphogenesis relationship: RO:0002212 GO:0001658 ! negatively regulates branching involved in ureteric bud morphogenesis creation_date: 2009-12-18T11:11:17Z [Term] id: GO:0090192 name: regulation of glomerulus development namespace: biological_process def: "Any process that modulates the rate, frequency or extent of glomerulus development, the progression of the glomerulus over time from its initial formation until its mature state. The glomerulus is a capillary tuft surrounded by Bowman's capsule in nephrons of the vertebrate kidney." [GOC:dph, GOC:tb, GOC:yaf] is_a: GO:0090183 ! regulation of kidney development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0032835 ! regulates glomerulus development relationship: RO:0002211 GO:0032835 ! regulates glomerulus development creation_date: 2009-12-18T11:17:13Z [Term] id: GO:0090193 name: positive regulation of glomerulus development namespace: biological_process def: "Any process that increases the rate, frequency or extent of glomerulus development, the progression of the glomerulus over time from its initial formation until its mature state. The glomerulus is a capillary tuft surrounded by Bowman's capsule in nephrons of the vertebrate kidney." [GOC:dph, GOC:tb, GOC:yaf] is_a: GO:0090184 ! positive regulation of kidney development is_a: GO:0090192 ! regulation of glomerulus development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0032835 ! positively regulates glomerulus development relationship: RO:0002213 GO:0032835 ! positively regulates glomerulus development creation_date: 2009-12-18T11:17:13Z [Term] id: GO:0090194 name: negative regulation of glomerulus development namespace: biological_process def: "Any process that decreases the rate, frequency or extent of glomerulus development, the progression of the glomerulus over time from its initial formation until its mature state. The glomerulus is a capillary tuft surrounded by Bowman's capsule in nephrons of the vertebrate kidney." [GOC:dph, GOC:tb, GOC:yaf] is_a: GO:0090185 ! negative regulation of kidney development is_a: GO:0090192 ! regulation of glomerulus development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0032835 ! negatively regulates glomerulus development relationship: RO:0002212 GO:0032835 ! negatively regulates glomerulus development creation_date: 2009-12-18T11:17:13Z [Term] id: GO:0090214 name: spongiotrophoblast layer developmental growth namespace: biological_process def: "The increase in size or mass of the spongiotrophoblast layer of the placenta where the increase in size or mass contributes to the progression of that layer over time from its formation to its mature state." [GOC:dph, GOC:tb] is_a: BFO:0000003 is_a: GO:0048589 ! developmental growth intersection_of: GO:0048589 ! developmental growth intersection_of: RO:0002298 UBERON:0004021 ! results in morphogenesis of spongiotrophoblast layer relationship: BFO:0000050 GO:0060712 ! part of spongiotrophoblast layer development relationship: RO:0002298 UBERON:0004021 ! results in morphogenesis of spongiotrophoblast layer creation_date: 2010-01-08T12:10:44Z [Term] id: GO:0090257 name: regulation of muscle system process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of a muscle system process, a multicellular organismal process carried out by any of the organs or tissues in a muscle system." [GOC:dph, GOC:tb] is_a: GO:0044057 ! regulation of system process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0003012 ! regulates muscle system process relationship: RO:0002211 GO:0003012 ! regulates muscle system process property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 creation_date: 2010-02-03T11:48:13Z [Term] id: GO:0090258 name: negative regulation of mitochondrial fission namespace: biological_process def: "Any process that decreases the rate, frequency or extent of mitochondrial fission. Mitochondrial fission is the division of a mitochondrion within a cell to form two or more separate mitochondrial compartments." [GOC:sl, GOC:tb] synonym: "negative regulation of mitochondrial division" EXACT [GOC:dph, GOC:tb] is_a: GO:0010639 ! negative regulation of organelle organization is_a: GO:0051093 ! negative regulation of developmental process is_a: GO:0090140 ! regulation of mitochondrial fission intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0000266 ! negatively regulates mitochondrial fission relationship: RO:0002212 GO:0000266 ! negatively regulates mitochondrial fission creation_date: 2010-02-03T04:05:32Z [Term] id: GO:0090273 name: regulation of somatostatin secretion namespace: biological_process def: "Any process that modulates the rate, frequency, extent of the regulated release of somatostatin from secretory granules in the D cells of the pancreas." [GOC:BHF] is_a: GO:0090276 ! regulation of peptide hormone secretion intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0070253 ! regulates somatostatin secretion relationship: RO:0002211 GO:0070253 ! regulates somatostatin secretion creation_date: 2010-02-05T02:54:14Z [Term] id: GO:0090274 name: positive regulation of somatostatin secretion namespace: biological_process def: "Any process that increases the rate, frequency, extent of the regulated release of somatostatin from secretory granules in the D cells of the pancreas." [GOC:BHF] is_a: GO:0090273 ! regulation of somatostatin secretion is_a: GO:0090277 ! positive regulation of peptide hormone secretion intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0070253 ! positively regulates somatostatin secretion relationship: RO:0002213 GO:0070253 ! positively regulates somatostatin secretion creation_date: 2010-02-05T02:54:14Z [Term] id: GO:0090275 name: negative regulation of somatostatin secretion namespace: biological_process def: "Any process that decreases the rate, frequency, extent of the regulated release of somatostatin from secretory granules in the D cells of the pancreas." [GOC:BHF] is_a: GO:0090273 ! regulation of somatostatin secretion is_a: GO:0090278 ! negative regulation of peptide hormone secretion intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0070253 ! negatively regulates somatostatin secretion relationship: RO:0002212 GO:0070253 ! negatively regulates somatostatin secretion creation_date: 2010-02-05T02:54:14Z [Term] id: GO:0090276 name: regulation of peptide hormone secretion namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of the regulated release of a peptide hormone from secretory granules." [GOC:tb] is_a: GO:0002791 ! regulation of peptide secretion is_a: GO:0046883 ! regulation of hormone secretion intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0030072 ! regulates peptide hormone secretion relationship: RO:0002211 GO:0030072 ! regulates peptide hormone secretion creation_date: 2010-02-05T02:56:39Z [Term] id: GO:0090277 name: positive regulation of peptide hormone secretion namespace: biological_process def: "Any process that increases the rate, frequency, or extent of the regulated release of a peptide hormone from secretory granules." [GOC:tb] is_a: GO:0002793 ! positive regulation of peptide secretion is_a: GO:0046887 ! positive regulation of hormone secretion is_a: GO:0090276 ! regulation of peptide hormone secretion intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0030072 ! positively regulates peptide hormone secretion relationship: RO:0002213 GO:0030072 ! positively regulates peptide hormone secretion creation_date: 2010-02-05T02:56:39Z [Term] id: GO:0090278 name: negative regulation of peptide hormone secretion namespace: biological_process def: "Any process that decreases the rate, frequency, or extent of the regulated release of a peptide hormone from secretory granules." [GOC:tb] is_a: GO:0002792 ! negative regulation of peptide secretion is_a: GO:0046888 ! negative regulation of hormone secretion is_a: GO:0090276 ! regulation of peptide hormone secretion intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0030072 ! negatively regulates peptide hormone secretion relationship: RO:0002212 GO:0030072 ! negatively regulates peptide hormone secretion creation_date: 2010-02-05T02:56:39Z [Term] id: GO:0090279 name: regulation of calcium ion import namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of the directed movement of calcium ions into a cell or organelle." [GOC:BHF] synonym: "regulation of transmembrane calcium influx" RELATED [GOC:tb] is_a: GO:0051924 ! regulation of calcium ion transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0070509 ! regulates calcium ion import relationship: RO:0002211 GO:0070509 ! regulates calcium ion import creation_date: 2010-02-08T05:11:20Z [Term] id: GO:0090280 name: positive regulation of calcium ion import namespace: biological_process def: "Any process that increases the rate, frequency, or extent of the directed movement of calcium ions into a cell or organelle." [GOC:BHF] synonym: "positive regulation of transmembrane calcium influx" RELATED [GOC:tb] is_a: GO:0051928 ! positive regulation of calcium ion transport is_a: GO:0090279 ! regulation of calcium ion import intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0070509 ! positively regulates calcium ion import relationship: RO:0002213 GO:0070509 ! positively regulates calcium ion import creation_date: 2010-02-08T05:11:20Z [Term] id: GO:0090281 name: negative regulation of calcium ion import namespace: biological_process def: "Any process that decreases the rate, frequency, or extent of the directed movement of calcium ions into a cell or organelle." [GOC:BHF] synonym: "negative regulation of transmembrane calcium influx" RELATED [GOC:tb] is_a: GO:0051926 ! negative regulation of calcium ion transport is_a: GO:0090279 ! regulation of calcium ion import intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0070509 ! negatively regulates calcium ion import relationship: RO:0002212 GO:0070509 ! negatively regulates calcium ion import creation_date: 2010-02-08T05:11:20Z [Term] id: GO:0090289 name: regulation of osteoclast proliferation namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of the multiplication or reproduction of osteoclasts, resulting in the expansion of an osteoclast cell population." [GOC:tb] is_a: GO:0070663 ! regulation of leukocyte proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0002158 ! regulates osteoclast proliferation relationship: RO:0002211 GO:0002158 ! regulates osteoclast proliferation creation_date: 2010-02-18T03:11:03Z [Term] id: GO:0090290 name: positive regulation of osteoclast proliferation namespace: biological_process def: "Any process that increases the rate, frequency, or extent of the multiplication or reproduction of osteoclasts, resulting in the expansion of an osteoclast cell population." [GOC:tb] is_a: GO:0070665 ! positive regulation of leukocyte proliferation is_a: GO:0090289 ! regulation of osteoclast proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0002158 ! positively regulates osteoclast proliferation relationship: RO:0002213 GO:0002158 ! positively regulates osteoclast proliferation creation_date: 2010-02-18T03:11:03Z [Term] id: GO:0090291 name: negative regulation of osteoclast proliferation namespace: biological_process def: "Any process that decreases the rate, frequency, or extent of the multiplication or reproduction of osteoclasts, resulting in the expansion of an osteoclast cell population." [GOC:tb] is_a: GO:0070664 ! negative regulation of leukocyte proliferation is_a: GO:0090289 ! regulation of osteoclast proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0002158 ! negatively regulates osteoclast proliferation relationship: RO:0002212 GO:0002158 ! negatively regulates osteoclast proliferation creation_date: 2010-02-18T03:11:03Z [Term] id: GO:0090299 name: regulation of neural crest formation namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of neural crest formation. Neural crest formation is the formation of the specialized region of ectoderm between the neural ectoderm (neural plate) and non-neural ectoderm. The neural crest gives rise to the neural crest cells that migrate away from this region as neural tube formation proceeds." [GOC:tb] is_a: GO:0010717 ! regulation of epithelial to mesenchymal transition is_a: GO:0022603 ! regulation of anatomical structure morphogenesis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0014029 ! regulates neural crest formation relationship: RO:0002211 GO:0014029 ! regulates neural crest formation creation_date: 2010-03-12T04:08:26Z [Term] id: GO:0090300 name: positive regulation of neural crest formation namespace: biological_process def: "Any process that increases the rate, frequency, or extent of neural crest formation. Neural crest formation is the formation of the specialized region of ectoderm between the neural ectoderm (neural plate) and non-neural ectoderm. The neural crest gives rise to the neural crest cells that migrate away from this region as neural tube formation proceeds." [GOC:tb] is_a: GO:0010718 ! positive regulation of epithelial to mesenchymal transition is_a: GO:0090299 ! regulation of neural crest formation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0014029 ! positively regulates neural crest formation relationship: RO:0002213 GO:0014029 ! positively regulates neural crest formation creation_date: 2010-03-12T04:08:26Z [Term] id: GO:0090301 name: negative regulation of neural crest formation namespace: biological_process def: "Any process that decreases the rate, frequency, or extent of neural crest formation. Neural crest formation is the formation of the specialized region of ectoderm between the neural ectoderm (neural plate) and non-neural ectoderm. The neural crest gives rise to the neural crest cells that migrate away from this region as neural tube formation proceeds." [GOC:tb] is_a: GO:0010719 ! negative regulation of epithelial to mesenchymal transition is_a: GO:0090299 ! regulation of neural crest formation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0014029 ! negatively regulates neural crest formation relationship: RO:0002212 GO:0014029 ! negatively regulates neural crest formation creation_date: 2010-03-12T04:08:26Z [Term] id: GO:0090303 name: positive regulation of wound healing namespace: biological_process def: "Any process that increases the rate, frequency, or extent of the series of events that restore integrity to a damaged tissue, following an injury." [GOC:BHF] is_a: GO:0061041 ! regulation of wound healing is_a: GO:1903036 ! positive regulation of response to wounding intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0042060 ! positively regulates wound healing relationship: RO:0002213 GO:0042060 ! positively regulates wound healing property_value: RO:0002161 NCBITaxon:4751 creation_date: 2010-03-22T02:12:03Z [Term] id: GO:0090304 name: nucleic acid metabolic process namespace: biological_process def: "Any cellular metabolic process involving nucleic acids." [GOC:dph, GOC:tb] comment: This term should not be used for direct annotation. It should be possible to make a more specific annotation to one of the children of this term. subset: gocheck_do_not_annotate is_a: GO:0006139 ! nucleobase-containing compound metabolic process is_a: GO:0043170 ! macromolecule metabolic process intersection_of: GO:0008152 ! metabolic process intersection_of: RO:0004007 CHEBI:33696 ! has primary input or output relationship: RO:0004007 CHEBI:33696 ! has primary input or output property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/26133" xsd:anyURI property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/27052" xsd:anyURI creation_date: 2010-04-07T10:18:47Z [Term] id: GO:0090316 name: positive regulation of intracellular protein transport namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the directed movement of proteins within cells." [GOC:tb] is_a: GO:0032388 ! positive regulation of intracellular transport is_a: GO:0033157 ! regulation of intracellular protein transport is_a: GO:0051222 ! positive regulation of protein transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0006886 ! positively regulates intracellular protein transport relationship: RO:0002213 GO:0006886 ! positively regulates intracellular protein transport creation_date: 2010-04-16T03:45:07Z [Term] id: GO:0090317 name: negative regulation of intracellular protein transport namespace: biological_process def: "Any process that decreases the frequency, rate or extent of the directed movement of proteins within cells." [GOC:tb] is_a: GO:0032387 ! negative regulation of intracellular transport is_a: GO:0033157 ! regulation of intracellular protein transport is_a: GO:0051224 ! negative regulation of protein transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0006886 ! negatively regulates intracellular protein transport relationship: RO:0002212 GO:0006886 ! negatively regulates intracellular protein transport creation_date: 2010-04-16T03:45:07Z [Term] id: GO:0090322 name: regulation of superoxide metabolic process namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of superoxide metabolism, the chemical reactions and pathways involving superoxide, the superoxide anion O2- (superoxide free radical), or any compound containing this species." [GOC:tb] synonym: "regulation of superoxide metabolism" EXACT [GOC:tb] is_a: GO:2000377 ! regulation of reactive oxygen species metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0006801 ! regulates superoxide metabolic process relationship: RO:0002211 GO:0006801 ! regulates superoxide metabolic process creation_date: 2010-05-06T02:29:05Z [Term] id: GO:0090325 name: regulation of locomotion involved in locomotory behavior namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of the self-propelled movement of a cell or organism from one location to another in a behavioral context; the aspect of locomotory behavior having to do with movement." [GOC:dph, GOC:kmv, GOC:tb] is_a: GO:0040012 ! regulation of locomotion is_a: GO:0050795 ! regulation of behavior intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0031987 ! regulates locomotion involved in locomotory behavior relationship: RO:0002211 GO:0031987 ! regulates locomotion involved in locomotory behavior creation_date: 2010-05-14T10:24:29Z [Term] id: GO:0090326 name: positive regulation of locomotion involved in locomotory behavior namespace: biological_process def: "Any process that increases the frequency, rate, or extent of the self-propelled movement of a cell or organism from one location to another in a behavioral context; the aspect of locomotory behavior having to do with movement." [GOC:dph, GOC:kmv, GOC:tb] is_a: GO:0040017 ! positive regulation of locomotion is_a: GO:0048520 ! positive regulation of behavior is_a: GO:0090325 ! regulation of locomotion involved in locomotory behavior intersection_of: GO:0050789 ! regulation of biological process intersection_of: RO:0002213 GO:0031987 ! positively regulates locomotion involved in locomotory behavior relationship: RO:0002213 GO:0031987 ! positively regulates locomotion involved in locomotory behavior creation_date: 2010-05-14T10:26:58Z [Term] id: GO:0090327 name: negative regulation of locomotion involved in locomotory behavior namespace: biological_process def: "Any process that decreases the frequency, rate, or extent of the self-propelled movement of a cell or organism from one location to another in a behavioral context; the aspect of locomotory behavior having to do with movement." [GOC:dph, GOC:kmv, GOC:tb] is_a: GO:0040013 ! negative regulation of locomotion is_a: GO:0048521 ! negative regulation of behavior is_a: GO:0090325 ! regulation of locomotion involved in locomotory behavior intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0031987 ! negatively regulates locomotion involved in locomotory behavior relationship: RO:0002212 GO:0031987 ! negatively regulates locomotion involved in locomotory behavior creation_date: 2010-05-14T10:26:58Z [Term] id: GO:0090328 name: regulation of olfactory learning namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of olfactory learning. Olfactory learning is any process in an organism in which a relatively long-lasting adaptive behavioral change occurs in response to (repeated) exposure to an olfactory cue." [GOC:dph, GOC:tb] is_a: GO:0031644 ! regulation of nervous system process is_a: GO:0048583 ! regulation of response to stimulus is_a: GO:0050795 ! regulation of behavior intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0008355 ! regulates olfactory learning relationship: RO:0002211 GO:0008355 ! regulates olfactory learning creation_date: 2010-05-14T10:37:22Z [Term] id: GO:0090335 name: regulation of brown fat cell differentiation namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of brown fat cell differentiation. Brown fat cell differentiation is the process in which a relatively unspecialized cell acquires specialized features of a brown adipocyte, an animal connective tissue cell involved in adaptive thermogenesis. Brown adipocytes contain multiple small droplets of triglycerides and a high number of mitochondria." [GOC:tb] xref: Reactome:R-HSA-9843743 "Transcriptional regulation of brown and beige adipocyte differentiation" is_a: GO:0045598 ! regulation of fat cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0050873 ! regulates brown fat cell differentiation relationship: RO:0002211 GO:0050873 ! regulates brown fat cell differentiation property_value: RO:0002161 NCBITaxon:8782 creation_date: 2010-06-01T03:16:57Z [Term] id: GO:0090336 name: positive regulation of brown fat cell differentiation namespace: biological_process def: "Any process that increases the rate, frequency, or extent of brown fat cell differentiation. Brown fat cell differentiation is the process in which a relatively unspecialized cell acquires specialized features of a brown adipocyte, an animal connective tissue cell involved in adaptive thermogenesis. Brown adipocytes contain multiple small droplets of triglycerides and a high number of mitochondria." [GOC:BHF] is_a: GO:0045600 ! positive regulation of fat cell differentiation is_a: GO:0090335 ! regulation of brown fat cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0050873 ! positively regulates brown fat cell differentiation relationship: RO:0002213 GO:0050873 ! positively regulates brown fat cell differentiation property_value: RO:0002161 NCBITaxon:8782 creation_date: 2010-06-01T03:19:26Z [Term] id: GO:0090394 name: negative regulation of excitatory postsynaptic potential namespace: biological_process def: "Any process that prevents the establishment or decreases the extent of the excitatory postsynaptic potential (EPSP) which is a temporary increase in postsynaptic potential due to the flow of positively charged ions into the postsynaptic cell. The flow of ions that causes an EPSP is an excitatory postsynaptic current (EPSC) and makes it easier for the neuron to fire an action potential." [GOC:BHF] synonym: "negative regulation of EPSP" RELATED [] synonym: "negative regulation of excitatory post-synaptic membrane potential" EXACT [] synonym: "reduction of excitatory postsynaptic membrane potential" EXACT [GOC:bf] is_a: GO:0048519 ! negative regulation of biological process is_a: GO:0098815 ! modulation of excitatory postsynaptic potential intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0060079 ! negatively regulates excitatory postsynaptic potential relationship: RO:0002212 GO:0060079 ! negatively regulates excitatory postsynaptic potential creation_date: 2010-12-15T01:43:12Z [Term] id: GO:0090407 name: organophosphate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the biosynthesis of deoxyribose phosphate, the phosphorylated sugar 2-deoxy-erythro-pentose." [GOC:chem_mtg] is_a: GO:0009058 ! biosynthetic process is_a: GO:0019637 ! organophosphate metabolic process intersection_of: GO:0009058 ! biosynthetic process intersection_of: RO:0004008 CHEBI:25710 ! has primary output relationship: RO:0004008 CHEBI:25710 ! has primary output creation_date: 2011-02-26T02:22:41Z [Term] id: GO:0090425 name: acinar cell differentiation namespace: biological_process def: "The epithelial cell differentiation process in which a relatively unspecialized cell acquires specialized features of an acinar cell, a secretory cell that is grouped together with other cells of the same type to form grape-shaped clusters known as acini." [GOC:dph, GOC:tb] is_a: GO:0002067 ! glandular epithelial cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000622 ! results in acquisition of features of acinar cell relationship: RO:0002315 CL:0000622 ! results in acquisition of features of acinar cell creation_date: 2012-05-04T09:24:48Z [Term] id: GO:0090435 name: protein localization to nuclear envelope namespace: biological_process def: "A process in which a protein is transported to, or maintained at, a location within a nuclear envelope." [GOC:tb] synonym: "protein localization in nuclear envelope" EXACT [] is_a: GO:0034504 ! protein localization to nucleus intersection_of: GO:0008104 ! intracellular protein localization intersection_of: RO:0002339 GO:0005635 ! has target end location nuclear envelope relationship: RO:0002339 GO:0005635 ! has target end location nuclear envelope creation_date: 2012-07-30T01:50:41Z [Term] id: GO:0090454 name: glutamate transmembrane import into vacuole namespace: biological_process def: "The directed movement of glutamate into the vacuole across the vacuolar membrane." [GOC:tb] synonym: "vacuolar glutamate import" RELATED [GOC:tb] is_a: GO:0006835 ! dicarboxylic acid transport is_a: GO:0015800 ! acidic amino acid transport is_a: GO:0032975 ! amino acid transmembrane import into vacuole is_a: GO:0071705 ! nitrogen compound transport is_a: GO:1905039 ! carboxylic acid transmembrane transport intersection_of: GO:0015800 ! acidic amino acid transport intersection_of: RO:0002338 GO:0005829 ! has target start location cytosol intersection_of: RO:0002339 GO:0005775 ! has target end location vacuolar lumen intersection_of: RO:0002342 GO:0016020 ! results in transport across membrane intersection_of: RO:0004009 CHEBI:14321 ! has primary input relationship: RO:0004009 CHEBI:14321 ! has primary input creation_date: 2012-09-24T14:12:46Z [Term] id: GO:0090461 name: intracellular glutamate homeostasis namespace: biological_process def: "A homeostatic process involved in the maintenance of a steady state level of glutamate within a cell." [GOC:tb] synonym: "cellular glutamate homeostasis" EXACT [] synonym: "glutamate homeostasis" EXACT [] is_a: GO:0080144 ! intracellular amino acid homeostasis intersection_of: GO:0019725 ! cellular homeostasis intersection_of: RO:0002332 CHEBI:14321 ! regulates levels of relationship: RO:0002332 CHEBI:14321 ! regulates levels of property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/24220" xsd:anyURI creation_date: 2012-09-24T14:22:02Z [Term] id: GO:0090493 name: catecholamine uptake namespace: biological_process def: "The directed movement of catecholamine into a cell." [GOC:dph, GOC:tb] is_a: GO:0051937 ! catecholamine transport intersection_of: GO:0006810 ! transport intersection_of: RO:0002338 GO:0005576 ! has target start location extracellular region intersection_of: RO:0002339 GO:0005622 ! has target end location intracellular anatomical structure intersection_of: RO:0004009 CHEBI:33567 ! has primary input relationship: RO:0002338 GO:0005576 ! has target start location extracellular region relationship: RO:0002339 GO:0005622 ! has target end location intracellular anatomical structure creation_date: 2012-10-17T11:06:17Z [Term] id: GO:0090494 name: dopamine uptake namespace: biological_process def: "The directed movement of dopamine into a cell." [GOC:dph, GOC:tb] is_a: GO:0015872 ! dopamine transport is_a: GO:0090493 ! catecholamine uptake intersection_of: GO:0006810 ! transport intersection_of: RO:0002338 GO:0005576 ! has target start location extracellular region intersection_of: RO:0002339 GO:0005622 ! has target end location intracellular anatomical structure intersection_of: RO:0004009 CHEBI:59905 ! has primary input creation_date: 2012-10-17T11:12:09Z [Term] id: GO:0090496 name: mesenchyme migration involved in limb bud formation namespace: biological_process def: "The migration of mesenchymal tissue that contributes to the formation of a limb bud." [GOC:dph, GOC:tb] is_a: GO:0090131 ! mesenchyme migration intersection_of: GO:0090131 ! mesenchyme migration intersection_of: BFO:0000050 GO:0060174 ! part of limb bud formation relationship: BFO:0000050 GO:0060174 ! part of limb bud formation creation_date: 2012-10-17T12:04:20Z [Term] id: GO:0090497 name: mesenchymal cell migration namespace: biological_process def: "The orderly movement of a mesenchymal cell from one site to another, often during the development of a multicellular organism." [GOC:dph, GOC:tb] is_a: BFO:0000003 is_a: GO:0001667 ! ameboidal-type cell migration intersection_of: GO:0016477 ! cell migration intersection_of: RO:0002565 CL:0008019 ! results in movement of mesenchymal cell relationship: RO:0002565 CL:0008019 ! results in movement of mesenchymal cell property_value: RO:0002161 NCBITaxon:4890 creation_date: 2012-10-17T12:08:17Z [Term] id: GO:0090513 name: L-histidine transmembrane import into vacuole namespace: biological_process def: "The directed movement of L-histidine into the vacuole across the vacuolar membrane." [GOC:al] synonym: "histidine transmembrane import into vacuole" BROAD [] synonym: "vacuolar histidine import" BROAD [GOC:tb] is_a: GO:0034490 ! basic amino acid transmembrane import into vacuole is_a: GO:0089709 ! L-histidine transmembrane transport is_a: GO:1902024 ! L-histidine transport intersection_of: GO:0015802 ! basic amino acid transport intersection_of: RO:0002338 GO:0005829 ! has target start location cytosol intersection_of: RO:0002339 GO:0005775 ! has target end location vacuolar lumen intersection_of: RO:0002342 GO:0016020 ! results in transport across membrane intersection_of: RO:0004009 CHEBI:57595 ! has primary input creation_date: 2012-12-14T11:25:52Z [Term] id: GO:0090515 name: L-glutamate transmembrane import into vacuole namespace: biological_process def: "The directed movement of L-glutamate into the vacuole across the vacuolar membrane." [GOC:al] is_a: GO:0015813 ! L-glutamate transmembrane transport is_a: GO:0090454 ! glutamate transmembrane import into vacuole intersection_of: GO:0015800 ! acidic amino acid transport intersection_of: RO:0002338 GO:0005829 ! has target start location cytosol intersection_of: RO:0002339 GO:0005775 ! has target end location vacuolar lumen intersection_of: RO:0002342 GO:0016020 ! results in transport across membrane intersection_of: RO:0004009 CHEBI:29985 ! has primary input creation_date: 2012-12-14T11:25:52Z [Term] id: GO:0090521 name: podocyte cell migration namespace: biological_process def: "The orderly movement of a podocyte from one site to another, often during the development of a multicellular organism or multicellular structure. A podocyte is a specialized kidney epithelial cell." [GOC:pm, PMID:21402783] synonym: "glomerular visceral epithelial cell migration" EXACT [] is_a: GO:0010631 ! epithelial cell migration intersection_of: GO:0016477 ! cell migration intersection_of: RO:0002565 CL:0000653 ! results in movement of podocyte relationship: RO:0002565 CL:0000653 ! results in movement of podocyte property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/23000" xsd:anyURI property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4890 creation_date: 2013-01-08T11:08:57Z [Term] id: GO:0090594 name: inflammatory response to wounding namespace: biological_process def: "The immediate defensive reaction by vertebrate tissue to injury caused by chemical or physical agents." [GOC:add] is_a: GO:0006954 ! inflammatory response is_a: GO:0009611 ! response to wounding creation_date: 2014-08-12T12:13:53Z [Term] id: GO:0090596 name: sensory organ morphogenesis namespace: biological_process def: "Morphogenesis of a sensory organ. A sensory organ is defined as a tissue or set of tissues that work together to receive and transmit signals from external or internal stimuli. Morphogenesis is the process in which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions." [GOC:kmv, ISBN:978-0199210893] is_a: GO:0009887 ! animal organ morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0000020 ! results in morphogenesis of sense organ relationship: BFO:0000050 GO:0007423 ! part of sensory organ development relationship: RO:0002298 UBERON:0000020 ! results in morphogenesis of sense organ creation_date: 2014-08-22T13:23:20Z [Term] id: GO:0090598 name: male anatomical structure morphogenesis namespace: biological_process def: "The processes by which anatomical structures that are only present in the male organism are generated and organized." [GOC:kmv, GOC:tb] is_a: BFO:0000003 is_a: GO:0009653 ! anatomical structure morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0014403 ! results in morphogenesis of male anatomical structure relationship: BFO:0000050 GO:0046661 ! part of male sex differentiation relationship: RO:0002298 UBERON:0014403 ! results in morphogenesis of male anatomical structure property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 creation_date: 2014-08-22T13:29:45Z [Term] id: GO:0090634 name: microglial cell mediated cytotoxicity namespace: biological_process def: "The directed killing of a target cell by a microglial cell." [GOC:BHF, GOC:nc, PMID:19100238] is_a: GO:0001909 ! leukocyte mediated cytotoxicity is_a: GO:0002444 ! myeloid leukocyte mediated immunity intersection_of: GO:0001906 ! cell killing intersection_of: RO:0002608 CL:0000129 ! process has causal agent microglial cell relationship: RO:0002608 CL:0000129 ! process has causal agent microglial cell creation_date: 2015-04-14T14:04:54Z [Term] id: GO:0090685 name: RNA localization to nucleus namespace: biological_process def: "A macromolecular localization process in which RNA is transported to and maintained in a location within the nucleus." [GOC:mah, PMID:26305931] synonym: "RNA localisation to nucleus" EXACT [GOC:mah] is_a: GO:0006403 ! RNA localization intersection_of: GO:0006403 ! RNA localization intersection_of: RO:0002339 GO:0005634 ! has target end location nucleus relationship: RO:0002339 GO:0005634 ! has target end location nucleus creation_date: 2016-07-19T17:00:49Z [Term] id: GO:0090713 name: immunological memory process namespace: biological_process def: "Any process of the immune system that can contribute to the formation of immunological memory or an immune response based upon activation of immunological memory." [GOC:add, PMID:26086132, PMID:26831526] is_a: GO:0002376 ! immune system process relationship: BFO:0000050 GO:0006955 ! part of immune response property_value: RO:0002161 NCBITaxon:4895 creation_date: 2016-11-11T12:20:30Z [Term] id: GO:0090715 name: immunological memory formation process namespace: biological_process def: "Any immunological memory process that can contribute to the formation of immunological memory." [GOC:add, PMID:26086132, PMID:26831526] is_a: GO:0090713 ! immunological memory process property_value: RO:0002161 NCBITaxon:4895 creation_date: 2016-11-11T12:25:47Z [Term] id: GO:0090741 name: pigment granule membrane namespace: cellular_component def: "Any membrane that is part of a pigment granule." [PMID:11294610] is_a: GO:0030659 ! cytoplasmic vesicle membrane is_a: GO:0098588 ! bounding membrane of organelle intersection_of: GO:0016020 ! membrane intersection_of: RO:0002007 GO:0048770 ! bounding layer of pigment granule relationship: RO:0002007 GO:0048770 ! bounding layer of pigment granule creation_date: 2017-05-16T22:33:39Z [Term] id: GO:0095500 name: acetylcholine receptor signaling pathway namespace: biological_process def: "The series of molecular signals generated as a consequence of an acetylcholine receptor binding to one of its physiological ligands." [GOC:mah] synonym: "acetylcholine receptor signalling pathway" EXACT [] is_a: GO:0098926 ! postsynaptic signal transduction intersection_of: GO:0007165 ! signal transduction intersection_of: RO:0002224 GO:0015464 ! starts with acetylcholine receptor activity relationship: BFO:0000050 GO:1905145 ! part of cellular response to acetylcholine relationship: RO:0002224 GO:0015464 ! starts with acetylcholine receptor activity [Term] id: GO:0097014 name: ciliary plasm namespace: cellular_component def: "All of the contents of a cilium, excluding the plasma membrane surrounding the cilium." [GOC:BHF, GOC:cilia, GOC:dos, PMID:17895364] comment: Note that we deem cilium and microtubule-based flagellum to be equivalent. Also, researchers consider the composition of both the plasm and the membrane of the cilium to be detectably different from that in the non-ciliary cytosol and plasma membrane (e.g. in terms of calcium ion concentration, membrane lipid composition, and more). For this reason, the term "ciliary plasm" is not linked to "cytoplasm". synonym: "cilial cytoplasm" RELATED [] synonym: "ciliary cytoplasm" RELATED [] synonym: "cilium cytoplasm" RELATED [] synonym: "cilium plasm" EXACT [] synonym: "microtubule-based flagellar cytoplasm" RELATED [] synonym: "microtubule-based flagellar matrix" NARROW [] synonym: "microtubule-based flagellum cytoplasm" RELATED [] synonym: "microtubule-based flagellum matrix" NARROW [] is_a: GO:0032838 ! plasma membrane bounded cell projection cytoplasm intersection_of: GO:0005737 ! cytoplasm intersection_of: BFO:0000050 GO:0005929 ! part of cilium relationship: BFO:0000050 GO:0005929 ! part of cilium property_value: RO:0002161 NCBITaxon:3176 property_value: RO:0002161 NCBITaxon:3378 property_value: RO:0002161 NCBITaxon:3398 property_value: RO:0002161 NCBITaxon:4890 property_value: RO:0002161 NCBITaxon:5782 creation_date: 2011-03-23T01:52:31Z [Term] id: GO:0097026 name: dendritic cell dendrite assembly namespace: biological_process def: "Formation of dendrites, branched cellular projections (or cytoplasmic extension) that are extended from the surface of a dendritic immune cell, and which enable the cell to sample luminal pathogens and increase the surface area for antigen presentation to T cells." [CL:0000451, GOC:BHF, PMID:12200351] comment: Note that dendrites of dendritic cells should not be confused with neuronal cell dendrites, which process electrical signals. synonym: "dendritic extension" BROAD [] is_a: GO:0120031 ! plasma membrane bounded cell projection assembly intersection_of: GO:0022607 ! cellular component assembly intersection_of: RO:0002588 GO:0097511 ! results in assembly of dendritic cell dendrite relationship: RO:0002588 GO:0097511 ! results in assembly of dendritic cell dendrite creation_date: 2011-03-31T04:52:53Z [Term] id: GO:0097028 name: dendritic cell differentiation namespace: biological_process def: "The process in which a precursor cell type acquires the specialized features of a dendritic cell. A dendritic cell is a leukocyte of dendritic lineage specialized in the uptake, processing, and transport of antigens to lymph nodes for the purpose of stimulating an immune response via T cell activation." [CL:0000451, GOC:pr] comment: Note that immunologists typically use the word 'maturation' to refer to dendritic cells undergoing the process that GO describes as 'cell differentiation'. is_a: GO:1903131 ! mononuclear cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000451 ! results in acquisition of features of dendritic cell relationship: RO:0002315 CL:0000451 ! results in acquisition of features of dendritic cell creation_date: 2011-04-01T10:08:42Z [Term] id: GO:0097029 name: mature conventional dendritic cell differentiation namespace: biological_process def: "The process in which antigen-activated dendritic cells acquire the specialized features of a mature conventional dendritic cell. Mature conventional dendritic cells upregulate the surface expression of MHC molecules, chemokine receptors and adhesion molecules, and increase the number of dendrites (cytoplasmic protrusions) in preparation for migration to lymphoid organs where they present antigen to T cells." [GOC:BHF, PMID:15845453] comment: Note that immunologists typically use the word 'maturation' to refer to dendritic cells undergoing the process that GO describes as 'cell differentiation'. is_a: GO:0002573 ! myeloid leukocyte differentiation is_a: GO:0097028 ! dendritic cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000841 ! results in acquisition of features of mature conventional dendritic cell relationship: RO:0002315 CL:0000841 ! results in acquisition of features of mature conventional dendritic cell creation_date: 2011-04-01T10:10:22Z [Term] id: GO:0097048 name: dendritic cell apoptotic process namespace: biological_process def: "Any apoptotic process in a dendritic cell, a cell of hematopoietic origin, typically resident in particular tissues, specialized in the uptake, processing, and transport of antigens to lymph nodes for the purpose of stimulating an immune response via T cell activation." [CL:0000451, GOC:BHF, GOC:mtg_apoptosis, PMID:15059845] synonym: "dendritic cell apoptosis" NARROW [] is_a: GO:0071887 ! leukocyte apoptotic process intersection_of: GO:0006915 ! apoptotic process intersection_of: BFO:0000066 CL:0000451 ! occurs in dendritic cell relationship: BFO:0000066 CL:0000451 ! occurs in dendritic cell creation_date: 2011-05-04T02:18:59Z [Term] id: GO:0097049 name: motor neuron apoptotic process namespace: biological_process def: "Any apoptotic process in a motor neuron, an efferent neuron that passes from the central nervous system or a ganglion toward or to a muscle and conducts an impulse that causes movement." [CL:0000100, GOC:BHF, GOC:mtg_apoptosis, PMID:14523086] synonym: "motoneuron apoptosis" EXACT [] synonym: "motor neuron apoptosis" NARROW [] is_a: GO:0051402 ! neuron apoptotic process intersection_of: GO:0006915 ! apoptotic process intersection_of: BFO:0000066 CL:0000100 ! occurs in motor neuron relationship: BFO:0000066 CL:0000100 ! occurs in motor neuron property_value: RO:0002161 NCBITaxon:4896 creation_date: 2011-05-04T02:21:43Z [Term] id: GO:0097050 name: type B pancreatic cell apoptotic process namespace: biological_process def: "Any apoptotic process in a type B pancreatic cell, a cell located towards center of the islets of Langerhans that secretes insulin." [CL:0000169, GOC:BHF, GOC:mtg_apoptosis, PMID:16087305] synonym: "pancreatic B cell apoptosis" EXACT [] synonym: "pancreatic beta cell apoptosis" EXACT [] synonym: "type B pancreatic cell apoptosis" NARROW [] is_a: GO:1904019 ! epithelial cell apoptotic process intersection_of: GO:0006915 ! apoptotic process intersection_of: BFO:0000066 CL:0000169 ! occurs in type B pancreatic cell relationship: BFO:0000066 CL:0000169 ! occurs in type B pancreatic cell property_value: RO:0002161 NCBITaxon:4751 creation_date: 2011-05-04T02:24:38Z [Term] id: GO:0097054 name: L-glutamate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of L-glutamate, the L enantiomer anion of 2-aminopentanedioic acid." [GOC:yaf] synonym: "L-glutamate anabolism" EXACT [] synonym: "L-glutamate biosynthesis" EXACT [] synonym: "L-glutamate formation" EXACT [] synonym: "L-glutamate synthesis" EXACT [] is_a: GO:0006537 ! glutamate biosynthetic process intersection_of: GO:0009058 ! biosynthetic process intersection_of: RO:0004008 CHEBI:29985 ! has primary output relationship: RO:0004008 CHEBI:29985 ! has primary output creation_date: 2011-05-24T04:30:38Z [Term] id: GO:0097060 name: synaptic membrane namespace: cellular_component def: "A specialized area of membrane on either the presynaptic or the postsynaptic side of a synapse, the junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell." [GOC:BHF, PMID:20410104] subset: goslim_synapse is_a: GO:0098590 ! plasma membrane region intersection_of: GO:0098590 ! plasma membrane region intersection_of: BFO:0000050 GO:0045202 ! part of synapse relationship: BFO:0000050 GO:0045202 ! part of synapse creation_date: 2011-06-07T11:22:09Z [Term] id: GO:0097084 name: vascular associated smooth muscle cell development namespace: biological_process def: "The process aimed at the progression of a vascular smooth muscle cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. A vascular smooth muscle cell is a non-striated, elongated, spindle-shaped cell found lining the blood vessels." [GOC:BHF] synonym: "vascular smooth muscle cell development" EXACT [] is_a: GO:0055001 ! muscle cell development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 CL:0000359 ! results in development of vascular associated smooth muscle cell relationship: BFO:0000050 GO:0035886 ! part of vascular associated smooth muscle cell differentiation relationship: RO:0002296 CL:0000359 ! results in development of vascular associated smooth muscle cell creation_date: 2011-06-20T04:03:08Z [Term] id: GO:0097086 name: amniotic stem cell differentiation namespace: biological_process def: "The process whereby a relatively unspecialized cell acquires specialized features of an amniotic stem cell. An amniotic stem cell is a mesenchymal stem cell extracted from amniotic fluid. Amniotic stem cells are able to differentiate into various tissue types such as skin, cartilage, cardiac tissue, nerves, muscle, and bone." [CL:0002639, GOC:yaf, PMID:20942606, Wikipedia:Amniotic_stem_cells] is_a: GO:0072497 ! mesenchymal stem cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0002639 ! results in acquisition of features of amniotic stem cell relationship: RO:0002315 CL:0002639 ! results in acquisition of features of amniotic stem cell creation_date: 2011-06-22T11:17:52Z [Term] id: GO:0097094 name: craniofacial suture morphogenesis namespace: biological_process def: "The process in which any suture between cranial and/or facial bones is generated and organized." [GOC:pr, GOC:sl, Wikipedia:Cranial_sutures, Wikipedia:Head_and_neck_anatomy#Musculoskeletal_system] is_a: BFO:0000003 is_a: GO:0009653 ! anatomical structure morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0009198 ! results in morphogenesis of craniofacial suture relationship: BFO:0000050 GO:0060349 ! part of bone morphogenesis relationship: BFO:0000050 GO:1904888 ! part of cranial skeletal system development relationship: RO:0002298 UBERON:0009198 ! results in morphogenesis of craniofacial suture creation_date: 2011-07-05T02:51:54Z [Term] id: GO:0097096 name: facial suture morphogenesis namespace: biological_process def: "The process in which any suture between facial bones is generated and organized." [GOC:pr, GOC:sl, Wikipedia:Cranial_sutures, Wikipedia:Head_and_neck_anatomy#Musculoskeletal_system] is_a: GO:0097094 ! craniofacial suture morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0009199 ! results in morphogenesis of facial suture relationship: RO:0002162 NCBITaxon:7776 ! in taxon Gnathostomata relationship: RO:0002298 UBERON:0009199 ! results in morphogenesis of facial suture creation_date: 2011-07-05T03:06:27Z [Term] id: GO:0097104 name: postsynaptic membrane assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form a postsynaptic membrane, a specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft)." [GOC:BHF, GOC:sjp, PMID:21424692] subset: goslim_synapse synonym: "post-synaptic membrane assembly" EXACT [] is_a: GO:0001941 ! postsynaptic membrane organization is_a: GO:0071709 ! membrane assembly intersection_of: GO:0009987 ! cellular process intersection_of: RO:0002588 GO:0045211 ! results in assembly of postsynaptic membrane relationship: BFO:0000050 GO:0099068 ! part of postsynapse assembly relationship: RO:0002588 GO:0045211 ! results in assembly of postsynaptic membrane creation_date: 2011-07-27T01:26:49Z [Term] id: GO:0097120 name: receptor localization to synapse namespace: biological_process def: "Any process in which a receptor is transported to, and/or maintained at the synapse, the junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell." [GOC:BHF, GOC:sjp, PMID:21525273] synonym: "receptor localisation to synapse" EXACT [] is_a: BFO:0000003 is_a: GO:0051179 ! localization intersection_of: GO:0051179 ! localization intersection_of: RO:0002339 GO:0045202 ! has target end location synapse intersection_of: RO:0004009 GO:0098802 ! has primary input plasma membrane signaling receptor complex relationship: RO:0002339 GO:0045202 ! has target end location synapse relationship: RO:0004009 GO:0098802 ! has primary input plasma membrane signaling receptor complex creation_date: 2011-07-31T09:20:30Z [Term] id: GO:0097152 name: mesenchymal cell apoptotic process namespace: biological_process def: "Any apoptotic process in a mesenchymal cell. A mesenchymal cell is a loosely associated cell that is part of the connective tissue in an organism. Mesenchymal cells give rise to more mature connective tissue cell types." [CL:0000134, GOC:mtg_apoptosis, GOC:yaf, PMID:18231833] synonym: "mesenchymal cell apoptosis" NARROW [] is_a: GO:0006915 ! apoptotic process intersection_of: GO:0006915 ! apoptotic process intersection_of: BFO:0000066 CL:0008019 ! occurs in mesenchymal cell relationship: BFO:0000066 CL:0008019 ! occurs in mesenchymal cell property_value: RO:0002161 NCBITaxon:4896 creation_date: 2011-09-06T02:31:59Z [Term] id: GO:0097154 name: GABAergic neuron differentiation namespace: biological_process def: "The process in which a neuroblast acquires the specialized structural and functional features of a GABAergic neuron." [GOC:kmv, PMID:11517269] is_a: GO:0030182 ! neuron differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000617 ! results in acquisition of features of GABAergic neuron relationship: RO:0002315 CL:0000617 ! results in acquisition of features of GABAergic neuron creation_date: 2011-09-14T09:39:11Z [Term] id: GO:0097177 name: mitochondrial ribosome binding namespace: molecular_function def: "Binding to a mitochondrial ribosome." [GOC:ans, PMID:20739282] is_a: GO:0043022 ! ribosome binding intersection_of: GO:0005488 ! binding intersection_of: RO:0004009 GO:0005761 ! has primary input mitochondrial ribosome relationship: RO:0004009 GO:0005761 ! has primary input mitochondrial ribosome creation_date: 2011-10-11T03:03:03Z [Term] id: GO:0097186 name: amelogenesis namespace: biological_process def: "The process whose specific outcome is the formation of tooth enamel, occurring in two stages: secretory stage and maturation stage." [GOC:cjm, GOC:sl, PMID:10206335, PMID:21196346] synonym: "enamel development" EXACT [] is_a: GO:0042475 ! odontogenesis of dentin-containing tooth is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0001752 ! results in formation of anatomical entity enamel relationship: RO:0002297 UBERON:0001752 ! results in formation of anatomical entity enamel property_value: RO:0002161 NCBITaxon:8782 creation_date: 2011-11-21T09:01:24Z [Term] id: GO:0097187 name: dentinogenesis namespace: biological_process def: "The process whose specific outcome is the formation of dentin, the mineralized tissue that constitutes the major bulk of teeth. Dentin may be one of three types: primary dentin, secondary dentin, and tertiary dentin." [GOC:cjm, GOC:sl, PMID:10206335, PMID:21196346] synonym: "dentin development" EXACT [] synonym: "dentine development" EXACT [] is_a: GO:0042475 ! odontogenesis of dentin-containing tooth is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0001751 ! results in formation of anatomical entity dentine relationship: RO:0002297 UBERON:0001751 ! results in formation of anatomical entity dentine property_value: RO:0002161 NCBITaxon:8782 creation_date: 2011-11-21T09:04:17Z [Term] id: GO:0097190 name: apoptotic signaling pathway namespace: biological_process def: "The series of molecular signals which triggers the apoptotic death of a cell. The pathway starts with reception of a signal, and ends when the execution phase of apoptosis is triggered." [GOC:mtg_apoptosis] comment: This term can be used to annotate gene products involved in apoptotic events happening downstream of the cross-talk point between the extrinsic and intrinsic apoptotic pathways. The cross-talk starts when caspase-8 cleaves Bid and truncated Bid interacts with mitochondria. From this point on it is not possible to distinguish between extrinsic and intrinsic pathways. synonym: "apoptotic signalling pathway" EXACT [GOC:mah] synonym: "induction of apoptosis by extracellular signals" EXACT [] xref: Reactome:R-HSA-193681 "Ceramide signalling" xref: Reactome:R-HSA-204998 "Cell death signalling via NRAGE, NRIF and NADE" xref: Reactome:R-HSA-75157 "FasL/ CD95L signaling" is_a: GO:0007165 ! signal transduction relationship: BFO:0000050 GO:0006915 ! part of apoptotic process property_value: RO:0002161 NCBITaxon:4896 creation_date: 2011-11-23T09:30:23Z [Term] id: GO:0097191 name: extrinsic apoptotic signaling pathway namespace: biological_process def: "The series of molecular signals in which a signal is conveyed from the cell surface to trigger the apoptotic death of a cell. The pathway starts with either a ligand binding to a cell surface receptor, or a ligand being withdrawn from a cell surface receptor (e.g. in the case of signaling by dependence receptors), and ends when the execution phase of apoptosis is triggered." [GOC:mtg_apoptosis, GOC:yaf, PMID:17340152] comment: Fas acts as a death receptor with a role in apoptosis, but can also act as a non-apoptotic signal transducer. synonym: "death receptor-mediated apoptosis" NARROW [] synonym: "extrinsic apoptosis" NARROW [] synonym: "extrinsic apoptotic pathway" EXACT [] synonym: "extrinsic apoptotic signaling pathway in presence of ligand" NARROW [] synonym: "extrinsic apoptotic signalling pathway" EXACT [GOC:mah] xref: Reactome:R-HSA-5357769 "Caspase activation via extrinsic apoptotic signalling pathway" is_a: GO:0007166 ! cell surface receptor signaling pathway is_a: GO:0097190 ! apoptotic signaling pathway property_value: RO:0002161 NCBITaxon:4896 creation_date: 2011-11-23T09:34:28Z [Term] id: GO:0097194 name: execution phase of apoptosis namespace: biological_process def: "A stage of the apoptotic process that starts with the controlled breakdown of the cell through the action of effector caspases or other effector molecules (e.g. cathepsins, calpains etc.). Key steps of the execution phase are rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died." [GOC:mtg_apoptosis, PMID:21760595] synonym: "apoptosis" NARROW [] synonym: "execution phase of apoptotic process" EXACT [] xref: Reactome:R-HSA-75153 "Apoptotic execution phase" is_a: BFO:0000003 is_a: GO:0009987 ! cellular process relationship: BFO:0000050 GO:0006915 ! part of apoptotic process relationship: BFO:0000051 GO:0032060 ! has part bleb assembly property_value: RO:0002161 NCBITaxon:4896 creation_date: 2011-11-23T09:45:24Z [Term] id: GO:0097205 name: renal filtration namespace: biological_process def: "A renal system process in which fluid circulating through the body is filtered through a barrier system." [GOC:pr, GOC:sart] is_a: GO:0003014 ! renal system process property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 creation_date: 2012-01-03T03:10:17Z [Term] id: GO:0097208 name: alveolar lamellar body namespace: cellular_component def: "A specialized secretory organelle found in type II pneumocytes and involved in the synthesis, secretion, and reutilization of pulmonary surfactant." [GOC:cjm, Wikipedia:Lamellar_granule] is_a: GO:0042599 ! lamellar body relationship: BFO:0000050 CL:0002063 ! part of pulmonary alveolar type 2 cell creation_date: 2012-01-04T02:33:04Z [Term] id: GO:0097209 name: epidermal lamellar body namespace: cellular_component def: "A specialized secretory organelle found in keratinocytes and involved in the formation of an impermeable, lipid-containing membrane that serves as a water barrier and is required for correct skin barrier function." [GOC:cjm, Wikipedia:Lamellar_granule] is_a: GO:0042599 ! lamellar body relationship: BFO:0000050 CL:0000312 ! part of keratinocyte relationship: RO:0002162 NCBITaxon:7742 ! in taxon Vertebrata creation_date: 2012-01-04T02:34:27Z [Term] id: GO:0097212 name: lysosomal membrane organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a lysosomal membrane. A lysosomal membrane is the lipid bilayer surrounding the lysosome and separating its contents from the cell cytoplasm." [GOC:yaf, PMID:20544854] synonym: "lysosomal membrane organisation" EXACT [GOC:mah] synonym: "lysosome membrane organization" EXACT [] is_a: GO:0061024 ! membrane organization intersection_of: GO:0016043 ! cellular component organization intersection_of: RO:0002592 GO:0005765 ! results in organization of lysosomal membrane relationship: BFO:0000050 GO:0007040 ! part of lysosome organization relationship: RO:0002592 GO:0005765 ! results in organization of lysosomal membrane property_value: RO:0002161 NCBITaxon:4751 creation_date: 2012-01-12T10:16:15Z [Term] id: GO:0097232 name: lamellar body membrane namespace: cellular_component def: "The lipid bilayer surrounding a lamellar body. A lamellar body is a membrane-bounded organelle, specialized for the storage and secretion of various substances (surfactant phospholipids, glycoproteins and acid phosphates) which are arranged in the form of tightly packed, concentric, membrane sheets or lamellae. Has some similar properties to, but is distinct from, a lysosome." [GOC:sl, PMID:11940594] is_a: GO:0030667 ! secretory granule membrane intersection_of: GO:0016020 ! membrane intersection_of: RO:0002007 GO:0042599 ! bounding layer of lamellar body relationship: RO:0002007 GO:0042599 ! bounding layer of lamellar body property_value: RO:0002161 NCBITaxon:4890 creation_date: 2012-01-26T10:28:42Z [Term] id: GO:0097233 name: alveolar lamellar body membrane namespace: cellular_component def: "The lipid bilayer surrounding an alveolar lamellar body, a specialized secretory organelle found in type II pneumocytes and involved in the synthesis, secretion, and reutilization of pulmonary surfactant." [GOC:sl, PMID:11940594] is_a: GO:0097232 ! lamellar body membrane intersection_of: GO:0016020 ! membrane intersection_of: RO:0002007 GO:0097208 ! bounding layer of alveolar lamellar body relationship: RO:0002007 GO:0097208 ! bounding layer of alveolar lamellar body creation_date: 2012-01-26T10:30:24Z [Term] id: GO:0097234 name: epidermal lamellar body membrane namespace: cellular_component def: "The lipid bilayer surrounding an epidermal lamellar body, a specialized secretory organelle found in keratinocytes and involved in the formation of an impermeable, lipid-containing membrane that serves as a water barrier and is required for correct skin barrier function." [GOC:sl, PMID:11940594] is_a: GO:0097232 ! lamellar body membrane intersection_of: GO:0016020 ! membrane intersection_of: RO:0002007 GO:0097209 ! bounding layer of epidermal lamellar body relationship: RO:0002007 GO:0097209 ! bounding layer of epidermal lamellar body creation_date: 2012-01-26T10:32:13Z [Term] id: GO:0097237 name: cellular response to toxic substance namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a toxic stimulus." [GOC:pr] is_a: GO:0009636 ! response to toxic substance is_a: GO:0070887 ! cellular response to chemical stimulus creation_date: 2012-02-02T12:23:31Z [Term] id: GO:0097252 name: oligodendrocyte apoptotic process namespace: biological_process def: "Any apoptotic process in an oligodendrocyte. Oligodendrocytes belong to a class of large neuroglial (macroglial) cells in the central nervous system, where they form the insulating myelin sheath of axons." [CL:0000128, GOC:mtg_apoptosis, GOC:yaf, PMID:16723520] synonym: "oligodendrocyte apoptosis" NARROW [] is_a: GO:0034349 ! glial cell apoptotic process intersection_of: GO:0006915 ! apoptotic process intersection_of: BFO:0000066 CL:0000128 ! occurs in oligodendrocyte relationship: BFO:0000066 CL:0000128 ! occurs in oligodendrocyte property_value: RO:0002161 NCBITaxon:4896 creation_date: 2012-03-05T10:51:15Z [Term] id: GO:0097254 name: renal tubular secretion namespace: biological_process def: "The elimination of substances from peritubular capillaries (or surrounding hemolymph in invertebrates) into the renal tubules to be incorporated subsequently into the urine. Substances that are secreted include organic anions, ammonia, potassium and drugs." [GOC:rph, PMID:25287933, Wikipedia:Renal_secretion#Secretion] is_a: GO:0003014 ! renal system process is_a: GO:0007588 ! excretion property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/22368" xsd:anyURI property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 creation_date: 2012-03-05T02:03:58Z [Term] id: GO:0097272 name: ammonium homeostasis namespace: biological_process def: "Any biological process involved in the maintenance of an internal steady state of ammonium." [GOC:yaf, PMID:12695560] synonym: "ammonia homeostasis" EXACT [] is_a: GO:0098771 ! inorganic ion homeostasis intersection_of: GO:0048878 ! chemical homeostasis intersection_of: RO:0002332 CHEBI:28938 ! regulates levels of relationship: RO:0002332 CHEBI:28938 ! regulates levels of creation_date: 2012-03-22T02:51:22Z [Term] id: GO:0097275 name: intracellular ammonium homeostasis namespace: biological_process def: "A homeostatic process involved in the maintenance of a steady state level of ammonium within a cell." [GOC:yaf, PMID:12695560] synonym: "cellular ammonia homeostasis" EXACT [] synonym: "cellular ammonium homeostasis" EXACT [] is_a: GO:0055082 ! intracellular chemical homeostasis is_a: GO:0097272 ! ammonium homeostasis intersection_of: GO:0055082 ! intracellular chemical homeostasis intersection_of: RO:0002332 CHEBI:28938 ! regulates levels of creation_date: 2012-03-22T02:54:38Z [Term] id: GO:0097283 name: keratinocyte apoptotic process namespace: biological_process def: "Any apoptotic process in a keratinocyte. A keratinocyte is an epidermal cell which synthesizes keratin and undergoes a characteristic change as it moves upward from the basal layers of the epidermis to the cornified (horny) layer of the skin." [CL:0000312, GOC:jc, GOC:mtg_apoptosis, PMID:10201527] synonym: "keratinocyte apoptosis" NARROW [] is_a: GO:1904019 ! epithelial cell apoptotic process intersection_of: GO:0006915 ! apoptotic process intersection_of: BFO:0000066 CL:0000312 ! occurs in keratinocyte relationship: BFO:0000066 CL:0000312 ! occurs in keratinocyte property_value: RO:0002161 NCBITaxon:4751 property_value: RO:0002161 NCBITaxon:6656 creation_date: 2012-03-29T10:20:51Z [Term] id: GO:0097284 name: hepatocyte apoptotic process namespace: biological_process def: "Any apoptotic process in a hepatocyte, the main structural component of the liver." [CL:0000182, GOC:jc, GOC:mtg_apoptosis, PMID:15856020] synonym: "hepatocyte apoptosis" NARROW [] is_a: GO:1904019 ! epithelial cell apoptotic process intersection_of: GO:0006915 ! apoptotic process intersection_of: BFO:0000066 CL:0000182 ! occurs in hepatocyte relationship: BFO:0000066 CL:0000182 ! occurs in hepatocyte property_value: RO:0002161 NCBITaxon:4751 creation_date: 2012-03-29T10:23:21Z [Term] id: GO:0097305 name: response to alcohol namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an alcohol stimulus." [GOC:pr, PMID:24014527] synonym: "process resulting in tolerance to alcohol" NARROW [] is_a: GO:1901700 ! response to oxygen-containing compound intersection_of: GO:0050896 ! response to stimulus intersection_of: RO:0004009 CHEBI:30879 ! has primary input relationship: RO:0004009 CHEBI:30879 ! has primary input creation_date: 2012-05-15T03:48:45Z [Term] id: GO:0097306 name: cellular response to alcohol namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an alcohol stimulus." [GOC:pr] is_a: GO:0097305 ! response to alcohol is_a: GO:1901701 ! cellular response to oxygen-containing compound intersection_of: GO:0070887 ! cellular response to chemical stimulus intersection_of: RO:0004009 CHEBI:30879 ! has primary input creation_date: 2012-05-15T03:49:51Z [Term] id: GO:0097324 name: melanocyte migration namespace: biological_process def: "The orderly movement of melanocytes from one site to another, often during the development of a multicellular organism. A melanocyte is a pigment cell derived from the neural crest. It contains melanin-filled pigment granules, which give a brown to black appearance." [CL:0000148, GOC:uh, PMID:22637532] is_a: GO:0010631 ! epithelial cell migration intersection_of: GO:0016477 ! cell migration intersection_of: RO:0002565 CL:0000148 ! results in movement of melanocyte relationship: RO:0002565 CL:0000148 ! results in movement of melanocyte property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4890 creation_date: 2012-06-08T10:08:18Z [Term] id: GO:0097355 name: protein localization to heterochromatin namespace: biological_process def: "Any process in which a protein is transported to, or maintained at, a part of a chromosome that is organized into heterochromatin." [GOC:mah] synonym: "protein localisation to heterochromatin" EXACT [GOC:mah] is_a: GO:0071168 ! protein localization to chromatin intersection_of: GO:0008104 ! intracellular protein localization intersection_of: RO:0002339 GO:0000792 ! has target end location heterochromatin relationship: RO:0002339 GO:0000792 ! has target end location heterochromatin creation_date: 2012-07-03T03:19:07Z [Term] id: GO:0097360 name: chorionic trophoblast cell proliferation namespace: biological_process def: "The multiplication or reproduction of chorionic trophoblast cells, resulting in the expansion of their population." [CL:0011101, GOC:BHF, PMID:15150278] is_a: BFO:0000003 is_a: GO:0008283 ! cell population proliferation intersection_of: GO:0008283 ! cell population proliferation intersection_of: RO:0012003 CL:0011101 ! acts on population of chorionic trophoblast cell relationship: RO:0012003 CL:0011101 ! acts on population of chorionic trophoblast cell property_value: RO:0002161 NCBITaxon:4751 creation_date: 2012-07-19T10:17:37Z [Term] id: GO:0097367 name: carbohydrate derivative binding namespace: molecular_function def: "Binding to a carbohydrate derivative." [GOC:pr] subset: goslim_agr subset: goslim_mouse is_a: BFO:0000003 is_a: GO:0005488 ! binding intersection_of: GO:0005488 ! binding intersection_of: RO:0004009 CHEBI:63299 ! has primary input relationship: RO:0004009 CHEBI:63299 ! has primary input creation_date: 2012-08-02T13:03:39Z [Term] id: GO:0097386 name: glial cell projection namespace: cellular_component def: "A prolongation or process extending from a glial cell." [GOC:mc] synonym: "glial process" RELATED [] synonym: "glial projection" RELATED [] is_a: GO:0120025 ! plasma membrane bounded cell projection intersection_of: GO:0120025 ! plasma membrane bounded cell projection intersection_of: BFO:0000050 CL:0000125 ! part of glial cell relationship: BFO:0000050 CL:0000125 ! part of glial cell creation_date: 2012-10-22T13:55:54Z [Term] id: GO:0097402 name: neuroblast migration namespace: biological_process def: "The orderly movement of a neuroblast from one site to another, often during the development of a multicellular organism or multicellular structure. A neuroblast is any cell that will divide and give rise to a neuron." [CL:0000031, GOC:jc, PMID:15543145] is_a: BFO:0000003 is_a: GO:0016477 ! cell migration intersection_of: GO:0016477 ! cell migration intersection_of: RO:0002565 CL:0000031 ! results in movement of neuroblast (sensu Vertebrata) relationship: RO:0002565 CL:0000031 ! results in movement of neuroblast (sensu Vertebrata) property_value: RO:0002161 NCBITaxon:4890 creation_date: 2012-10-29T08:24:37Z [Term] id: GO:0097410 name: hippocampal interneuron differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a hippocampal interneuron." [CL:1001569, GOC:jc, PMID:19655320] is_a: GO:0021895 ! cerebral cortex neuron differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:1001569 ! results in acquisition of features of hippocampal interneuron relationship: BFO:0000050 GO:0021766 ! part of hippocampus development relationship: RO:0002315 CL:1001569 ! results in acquisition of features of hippocampal interneuron creation_date: 2012-11-04T10:58:28Z [Term] id: GO:0097427 name: microtubule bundle namespace: cellular_component def: "An arrangement of closely apposed microtubules running parallel to each other." [NIF_Subcellular:sao1872343973] synonym: "microtubule fascicle" EXACT [] xref: NIF_Subcellular:sao1872343973 is_a: GO:0110165 ! cellular anatomical structure relationship: BFO:0000050 GO:0005856 ! part of cytoskeleton relationship: BFO:0000051 GO:0005874 ! has part microtubule creation_date: 2012-11-07T15:01:27Z [Term] id: GO:0097432 name: hippocampal pyramidal neuron differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a hippocampal pyramidal neuron, a pyramidal cell of the hippocampus." [CL:1001571, GOC:jc, PMID:19342486] is_a: GO:0021859 ! pyramidal neuron differentiation is_a: GO:0021895 ! cerebral cortex neuron differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:1001571 ! results in acquisition of features of hippocampal pyramidal neuron relationship: RO:0002315 CL:1001571 ! results in acquisition of features of hippocampal pyramidal neuron creation_date: 2012-11-22T09:33:31Z [Term] id: GO:0097435 name: supramolecular fiber organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a supramolecular fiber, a polymer consisting of an indefinite number of protein or protein complex subunits that have polymerised to form a fiber-shaped structure." [GOC:pr] synonym: "extracellular fibril organisation" NARROW [] synonym: "extracellular fibril organization" NARROW [] synonym: "extracellular fibril organization and biogenesis" NARROW [GOC:mah] synonym: "fibril organisation" RELATED [] synonym: "fibril organization" RELATED [] is_a: GO:0016043 ! cellular component organization intersection_of: GO:0016043 ! cellular component organization intersection_of: RO:0002592 GO:0099512 ! results in organization of supramolecular fiber relationship: RO:0002592 GO:0099512 ! results in organization of supramolecular fiber creation_date: 2012-11-27T15:46:25Z [Term] id: GO:0097447 name: dendritic tree namespace: cellular_component def: "The entire complement of dendrites for a neuron, consisting of each primary dendrite and all its branches." [GOC:aruk, GOC:bc, NIF_Subcellular:sao172297168] xref: NIF_Subcellular:sao172297168 is_a: GO:0043005 ! neuron projection relationship: BFO:0000050 GO:0036477 ! part of somatodendritic compartment relationship: BFO:0000051 GO:0030425 ! has part dendrite property_value: skos:prefLabel "dendritic tree" xsd:string creation_date: 2012-12-17T12:31:49Z [Term] id: GO:0097449 name: astrocyte projection namespace: cellular_component def: "A prolongation or process extending from the soma of an astrocyte and wrapping around neurons." [NIF_Subcellular:sao1630537580] synonym: "astrocyte process" EXACT [] synonym: "peripheral astrocyte process" RELATED [NIF_Subcellular:sao1573004591, PMID:12445894] synonym: "vellous process" RELATED [NIF_Subcellular:sao1189060993] xref: NIF_Subcellular:sao1630537580 is_a: GO:0097386 ! glial cell projection intersection_of: GO:0120025 ! plasma membrane bounded cell projection intersection_of: BFO:0000050 CL:0000127 ! part of astrocyte relationship: BFO:0000050 CL:0000127 ! part of astrocyte creation_date: 2012-12-17T13:29:55Z [Term] id: GO:0097454 name: Schwann cell microvillus namespace: cellular_component def: "Small finger-like extension of a Schwann cell that contacts the nodal membrane." [NIF_Subcellular:sao1890444066, PMID:15988042] xref: NIF_Subcellular:sao1890444066 is_a: GO:0005902 ! microvillus is_a: GO:0097386 ! glial cell projection intersection_of: GO:0005902 ! microvillus intersection_of: BFO:0000050 CL:0002573 ! part of Schwann cell relationship: BFO:0000050 CL:0002573 ! part of Schwann cell creation_date: 2012-12-19T13:01:02Z [Term] id: GO:0097457 name: hippocampal mossy fiber namespace: cellular_component def: "An axon of a hippocampal granule cell, including dentate gyrus granule cell and CA3 granule cell, characterized by expansions (mossy fiber expansions) giving the fibers a mossy appearance. These unmyelinated axons were first described by Ramon y Cajal." [NIF_Subcellular:nlx_subcell_100312, PMID:17765709, PMID:20554881, PMID:24336151] xref: NIF_Subcellular:nlx_subcell_100312 is_a: GO:0030424 ! axon relationship: BFO:0000050 CL:0001033 ! part of hippocampal granule cell property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/25796" xsd:anyURI property_value: skos:prefLabel "hippocampal mossy fiber" xsd:string creation_date: 2012-12-19T16:51:57Z [Term] id: GO:0097473 name: retinal rod cell apoptotic process namespace: biological_process def: "Any apoptotic process in a retinal rod cell, one of the two photoreceptor cell types of the vertebrate retina." [CL:0000604, GOC:jc, PMID:17202487] synonym: "rod photoreceptor apoptotic process" EXACT [] is_a: GO:0051402 ! neuron apoptotic process is_a: GO:1990009 ! retinal cell apoptotic process intersection_of: GO:0006915 ! apoptotic process intersection_of: BFO:0000066 CL:0000604 ! occurs in retinal rod cell relationship: BFO:0000066 CL:0000604 ! occurs in retinal rod cell property_value: RO:0002161 NCBITaxon:4896 creation_date: 2013-03-21T09:44:45Z [Term] id: GO:0097474 name: retinal cone cell apoptotic process namespace: biological_process def: "Any apoptotic process in a retinal cone cell, one of the two photoreceptor cell types of the vertebrate retina." [CL:0000573, GOC:jc] synonym: "cone photoreceptor apoptotic process" EXACT [] is_a: GO:0051402 ! neuron apoptotic process is_a: GO:1990009 ! retinal cell apoptotic process intersection_of: GO:0006915 ! apoptotic process intersection_of: BFO:0000066 CL:0000573 ! occurs in retinal cone cell relationship: BFO:0000066 CL:0000573 ! occurs in retinal cone cell property_value: RO:0002161 NCBITaxon:4896 creation_date: 2013-03-21T09:46:22Z [Term] id: GO:0097475 name: motor neuron migration namespace: biological_process def: "The orderly movement of a motor neuron from one site to another. A motor neuron is an efferent neuron that passes from the central nervous system or a ganglion toward or to a muscle and conducts an impulse that causes movement." [CL:0000100, GOC:yaf, PMID:20711475] is_a: GO:0001764 ! neuron migration intersection_of: GO:0016477 ! cell migration intersection_of: RO:0002565 CL:0000100 ! results in movement of motor neuron relationship: RO:0002565 CL:0000100 ! results in movement of motor neuron creation_date: 2013-04-23T13:00:46Z [Term] id: GO:0097476 name: spinal cord motor neuron migration namespace: biological_process def: "The orderly movement of a spinal cord motor neuron from one site to another. A spinal cord motor neuron is a motor neuron that passes from the spinal cord toward or to a muscle and conducts an impulse that causes movement." [CL:0011001, GOC:yaf, PMID:20711475] is_a: GO:0097475 ! motor neuron migration intersection_of: GO:0016477 ! cell migration intersection_of: RO:0002565 CL:0011001 ! results in movement of spinal cord motor neuron relationship: RO:0002565 CL:0011001 ! results in movement of spinal cord motor neuron creation_date: 2013-04-23T13:03:46Z [Term] id: GO:0097477 name: lateral motor column neuron migration namespace: biological_process def: "The orderly movement of a lateral motor column neuron from one site to another. A lateral motor column neuron is a motor neuron that is generated only on limb levels and send axons into the limb mesenchyme." [CL:0011002, GOC:yaf, PMID:20711475] is_a: GO:0097476 ! spinal cord motor neuron migration intersection_of: GO:0016477 ! cell migration intersection_of: RO:0002565 CL:0011002 ! results in movement of lateral motor column neuron relationship: RO:0002565 CL:0011002 ! results in movement of lateral motor column neuron creation_date: 2013-04-23T13:05:32Z [Term] id: GO:0097499 name: protein localization to non-motile cilium namespace: biological_process def: "A process in which a protein is transported to, or maintained in, a location within a non-motile cilium." [GOC:cilia, GOC:kmv, PMID:23128241] synonym: "protein localization to nonmotile primary cilium" RELATED [] is_a: GO:0061512 ! protein localization to cilium intersection_of: GO:0008104 ! intracellular protein localization intersection_of: RO:0002339 GO:0097730 ! has target end location non-motile cilium relationship: RO:0002339 GO:0097730 ! has target end location non-motile cilium property_value: RO:0002161 NCBITaxon:3176 property_value: RO:0002161 NCBITaxon:3378 property_value: RO:0002161 NCBITaxon:3398 property_value: RO:0002161 NCBITaxon:4890 property_value: RO:0002161 NCBITaxon:5782 creation_date: 2013-08-13T12:16:26Z [Term] id: GO:0097511 name: dendritic cell dendrite namespace: cellular_component def: "A branched cellular projection (or cytoplasmic extension) that is extended from the surface of a dendritic immune cell, and which enables the cell to sample luminal pathogens and increase the surface area for antigen presentation to T cells." [CL:0000451, GOC:BHF, GOC:cjm, PMID:12200351] is_a: GO:0120025 ! plasma membrane bounded cell projection intersection_of: GO:0120025 ! plasma membrane bounded cell projection intersection_of: BFO:0000050 CL:0000451 ! part of dendritic cell relationship: BFO:0000050 CL:0000451 ! part of dendritic cell creation_date: 2013-10-16T13:02:25Z [Term] id: GO:0097512 name: cardiac myofibril namespace: cellular_component def: "A cardiac myofibril is a myofibril specific to cardiac muscle cells." [GOC:cjm, GOC:devbiol] is_a: GO:0030016 ! myofibril intersection_of: GO:0030016 ! myofibril intersection_of: BFO:0000050 CL:0000746 ! part of cardiac muscle cell relationship: BFO:0000050 CL:0000746 ! part of cardiac muscle cell creation_date: 2013-10-16T13:04:58Z [Term] id: GO:0097524 name: sperm plasma membrane namespace: cellular_component def: "A plasma membrane that is part of a sperm cell." [GOC:cjm] is_a: GO:0005886 ! plasma membrane intersection_of: GO:0005886 ! plasma membrane intersection_of: BFO:0000050 CL:0000019 ! part of sperm relationship: BFO:0000050 CL:0000019 ! part of sperm property_value: RO:0002161 NCBITaxon:3176 property_value: RO:0002161 NCBITaxon:3378 property_value: RO:0002161 NCBITaxon:3398 property_value: RO:0002161 NCBITaxon:4751 property_value: RO:0002161 NCBITaxon:5782 creation_date: 2013-10-18T11:31:17Z [Term] id: GO:0097529 name: myeloid leukocyte migration namespace: biological_process def: "The movement of a myeloid leukocyte within or between different tissues and organs of the body." [GOC:cvs, PMID:22342843, PMID:24157461] is_a: GO:0050900 ! leukocyte migration intersection_of: GO:0016477 ! cell migration intersection_of: RO:0002565 CL:0000766 ! results in movement of myeloid leukocyte relationship: RO:0002565 CL:0000766 ! results in movement of myeloid leukocyte creation_date: 2013-11-11T13:59:43Z [Term] id: GO:0097530 name: granulocyte migration namespace: biological_process def: "The movement of a granulocyte within or between different tissues and organs of the body." [GOC:cvs, PMID:24163421, PMID:24193336] is_a: GO:0097529 ! myeloid leukocyte migration intersection_of: GO:0016477 ! cell migration intersection_of: RO:0002565 CL:0000094 ! results in movement of granulocyte relationship: RO:0002565 CL:0000094 ! results in movement of granulocyte creation_date: 2013-11-11T14:00:44Z [Term] id: GO:0097531 name: mast cell migration namespace: biological_process def: "The movement of a mast cell within or between different tissues and organs of the body." [GOC:cvs, PMID:24152847] is_a: GO:0097529 ! myeloid leukocyte migration intersection_of: GO:0016477 ! cell migration intersection_of: RO:0002565 CL:0000097 ! results in movement of mast cell relationship: RO:0002565 CL:0000097 ! results in movement of mast cell creation_date: 2013-11-11T14:01:41Z [Term] id: GO:0097534 name: lymphoid lineage cell migration namespace: biological_process def: "The orderly movement of a lymphoid lineage cell from one site to another. A lymphoid lineage cell, also called a lymphoid lineage restricted progenitor cell, is a progenitor cell restricted to the lymphoid lineage." [GOC:pr, PMID:22342843] synonym: "lymphoid lineage restricted progenitor cell migration" EXACT [] is_a: BFO:0000003 is_a: GO:0016477 ! cell migration intersection_of: GO:0016477 ! cell migration intersection_of: RO:0002565 CL:0000838 ! results in movement of lymphoid lineage restricted progenitor cell relationship: RO:0002565 CL:0000838 ! results in movement of lymphoid lineage restricted progenitor cell property_value: RO:0002161 NCBITaxon:4890 creation_date: 2013-11-28T10:47:15Z [Term] id: GO:0097536 name: thymus epithelium morphogenesis namespace: biological_process def: "The process in which the thymus epithelium is generated and organized." [GOC:pr, PMID:22342843] synonym: "thymic epithelium morphogenesis" EXACT [] is_a: GO:0002009 ! morphogenesis of an epithelium intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0003846 ! results in morphogenesis of thymus epithelium relationship: BFO:0000050 GO:0048538 ! part of thymus development relationship: RO:0002298 UBERON:0003846 ! results in morphogenesis of thymus epithelium creation_date: 2013-11-28T10:51:03Z [Term] id: GO:0097540 name: axonemal central pair namespace: cellular_component def: "Part of the axoneme consisting of the inner two microtubule doublets of the 9+2 axoneme occurring in most motile cilia." [GOC:cilia, GOC:krc, PMID:24283352] synonym: "axonemal microtubule central pair" EXACT [] synonym: "axoneme central pair" EXACT [] synonym: "axoneme microtubule central pair" EXACT [] synonym: "central pair" BROAD [] synonym: "central-pair microtubules" RELATED [] is_a: GO:0110165 ! cellular anatomical structure relationship: BFO:0000050 GO:1990716 ! part of axonemal central apparatus relationship: BFO:0000051 GO:1990719 ! has part C1 axonemal microtubule relationship: BFO:0000051 GO:1990720 ! has part C2 axonemal microtubule property_value: RO:0002161 NCBITaxon:3176 property_value: RO:0002161 NCBITaxon:3378 property_value: RO:0002161 NCBITaxon:3398 property_value: RO:0002161 NCBITaxon:4890 property_value: RO:0002161 NCBITaxon:5782 creation_date: 2013-12-12T11:07:09Z [Term] id: GO:0097545 name: axonemal doublet microtubule namespace: cellular_component def: "A cellular anatomical entity that is part of an axoneme consisting of a doublet microtubule." [GOC:cilia, GOC:krc, GOC:pr, https://github.com/geneontology/go-ontology/issues/26128, PMID:5044758, PMID:5664206, Wikipedia:Axoneme] synonym: "axonemal outer doublet" EXACT [] synonym: "axoneme outer doublet" EXACT [] synonym: "DMT" RELATED [] synonym: "outer doublet" BROAD [] synonym: "outer-doublet microtubules" RELATED [] is_a: GO:0110165 ! cellular anatomical structure relationship: BFO:0000050 GO:0005930 ! part of axoneme relationship: BFO:0000051 GO:0097649 ! has part A axonemal microtubule relationship: BFO:0000051 GO:0097650 ! has part B axonemal microtubule property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/26128" xsd:anyURI property_value: RO:0002161 NCBITaxon:3176 property_value: RO:0002161 NCBITaxon:3378 property_value: RO:0002161 NCBITaxon:3398 property_value: RO:0002161 NCBITaxon:4890 property_value: RO:0002161 NCBITaxon:5782 creation_date: 2013-12-12T11:19:29Z [Term] id: GO:0097553 name: calcium ion transmembrane import into cytosol namespace: biological_process def: "A process in which a calcium ion is transported from one side of a membrane to the other into the cytosol by means of some agent such as a transporter or pore." [GOC:vw] synonym: "calcium transmembrane import into cytosol" BROAD [] synonym: "cytosolic calcium ion transport" BROAD [] is_a: GO:0070588 ! calcium ion transmembrane transport intersection_of: GO:0055085 ! transmembrane transport intersection_of: RO:0002339 GO:0005829 ! has target end location cytosol intersection_of: RO:0004009 CHEBI:29108 ! has primary input relationship: RO:0002339 GO:0005829 ! has target end location cytosol property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/23015" xsd:anyURI creation_date: 2014-01-23T11:05:13Z [Term] id: GO:0097576 name: vacuole fusion namespace: biological_process def: "Merging of two or more vacuoles, or of vacuoles and vesicles within a cell to form a single larger vacuole." [GOC:pr, GOC:vw, Wikipedia:Vacuole] is_a: GO:0007033 ! vacuole organization is_a: GO:0048284 ! organelle fusion intersection_of: GO:0009987 ! cellular process intersection_of: RO:0012008 GO:0005773 ! results in fusion of vacuole relationship: RO:0012008 GO:0005773 ! results in fusion of vacuole creation_date: 2014-02-28T09:49:31Z [Term] id: GO:0097623 name: potassium ion export across plasma membrane namespace: biological_process def: "The directed movement of potassium ions from inside of a cell, across the plasma membrane and into the extracellular region." [GOC:vw, PMID:11932440] synonym: "potassium export" BROAD [GOC:mah] synonym: "potassium export across plasma membrane" EXACT [] synonym: "potassium ion export" BROAD [] synonym: "potassium ion export from cell" EXACT [] is_a: GO:0071805 ! potassium ion transmembrane transport is_a: GO:0140115 ! export across plasma membrane intersection_of: GO:0006810 ! transport intersection_of: RO:0002338 GO:0005829 ! has target start location cytosol intersection_of: RO:0002339 GO:0005576 ! has target end location extracellular region intersection_of: RO:0002342 GO:0005886 ! results in transport across plasma membrane intersection_of: RO:0004009 CHEBI:29103 ! has primary input property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/14265" xsd:anyURI creation_date: 2009-12-16T11:10:45Z [Term] id: GO:0097628 name: distal tip cell migration namespace: biological_process def: "The orderly movement of a distal tip cell." [CL:0000661, GOC:mm2, PMID:24968003] is_a: BFO:0000003 is_a: GO:0016477 ! cell migration intersection_of: GO:0016477 ! cell migration intersection_of: RO:0002565 CL:0000661 ! results in movement of distal tip cell (sensu Nematoda) relationship: RO:0002565 CL:0000661 ! results in movement of distal tip cell (sensu Nematoda) property_value: RO:0002161 NCBITaxon:4890 creation_date: 2014-08-20T16:06:53Z [Term] id: GO:0097642 name: calcitonin family receptor activity namespace: molecular_function def: "Combining with any member of the calcitonin family (e.g. adrenomedullin, adrenomedullin 2 (intermedin), amylin, calcitonin and calcitonin gene-related peptides (CGRPs)) to initiate a change in cell activity." [GOC:bhm, InterPro:IPR003287, PMID:10871296, PMID:12037140, PMID:18687416] is_a: GO:0008528 ! G protein-coupled peptide receptor activity creation_date: 2014-09-08T15:32:19Z [Term] id: GO:0097644 name: calcitonin family binding namespace: molecular_function def: "Binding to a member of the calcitonin family (e.g. adrenomedullin, adrenomedullin 2 (intermedin), amylin, calcitonin and calcitonin gene-related peptides (CGRPs))." [GOC:bhm, InterPro:IPR021116, PMID:10871296, PMID:12037140, PMID:18687416] is_a: GO:0017046 ! peptide hormone binding creation_date: 2014-09-08T20:50:52Z [Term] id: GO:0097648 name: G protein-coupled receptor complex namespace: cellular_component def: "A protein complex that contains G protein-coupled receptors." [GOC:bhm] synonym: "G-protein coupled receptor complex" EXACT [] is_a: GO:0098802 ! plasma membrane signaling receptor complex creation_date: 2014-09-10T09:14:30Z [Term] id: GO:0097649 name: A axonemal microtubule namespace: cellular_component def: "A complete microtubule with 13 protofilaments that fuses with an incomplete microtubule called B tubule (containing 10 protofilaments only) to form an axonemal outer doublet. Inner and outer dynein arms, as well as the radial spoke, are attached to the A tubule." [GOC:cilia, ISBN:0716731363] synonym: "A tubule" BROAD [] is_a: GO:0005879 ! axonemal microtubule relationship: BFO:0000050 GO:0097545 ! part of axonemal doublet microtubule property_value: RO:0002161 NCBITaxon:3176 property_value: RO:0002161 NCBITaxon:3378 property_value: RO:0002161 NCBITaxon:3398 property_value: RO:0002161 NCBITaxon:4890 property_value: RO:0002161 NCBITaxon:5782 creation_date: 2014-09-10T20:41:28Z [Term] id: GO:0097650 name: B axonemal microtubule namespace: cellular_component def: "An incomplete microtubule containing 10 protofilaments that fuses with a complete microtubule called A tubule (containing 13 protofilaments) to form an axonemal outer doublet." [GOC:cilia, ISBN:0716731363] synonym: "B tubule" BROAD [] is_a: GO:0005879 ! axonemal microtubule relationship: BFO:0000050 GO:0097545 ! part of axonemal doublet microtubule property_value: RO:0002161 NCBITaxon:3176 property_value: RO:0002161 NCBITaxon:3378 property_value: RO:0002161 NCBITaxon:3398 property_value: RO:0002161 NCBITaxon:4890 property_value: RO:0002161 NCBITaxon:5782 creation_date: 2014-09-10T20:43:18Z [Term] id: GO:0097708 name: intracellular vesicle namespace: cellular_component def: "Any vesicle that is part of the intracellular region." [GOC:vesicles] is_a: GO:0031982 ! vesicle is_a: GO:0043231 ! intracellular membrane-bounded organelle intersection_of: GO:0031982 ! vesicle intersection_of: BFO:0000050 GO:0005622 ! part of intracellular anatomical structure creation_date: 2016-03-29T17:39:45Z [Term] id: GO:0097711 name: ciliary basal body-plasma membrane docking namespace: biological_process def: "The docking of a cytosolic centriole/basal body to the plasma membrane via the ciliary transition fibers. In some species this may happen via an intermediate step, by first docking to the ciliary vesicle via the ciliary transition fibers. The basal body-ciliary vesicle then relocates to the plasma membrane, followed by the ciliary vesicle fusing with the plasma membrane, effectively attaching the basal body to the plasma membrane." [GOC:cilia, PMID:13978319, PMID:23348840, PMID:23530209, PMID:25686250, PMID:26981235] comment: Basal bodies in jawed vertebrates appear to first attach to a ciliary vesicle. It is unclear how specific this is to jawed vertebrates or if other organisms also employ this sequence. Some species like Giardia intestinalis do not relocate their basal bodies to the plasma membrane, but have their axonemes extend through the cytosol to then protrude out of the cell to form flagella. synonym: "anchoring of the basal body to the plasma membrane" RELATED [] synonym: "ciliary basal body docking" EXACT [] xref: Reactome:R-HSA-5620912 "Anchoring of the basal body to the plasma membrane" is_a: GO:0140056 ! organelle localization by membrane tethering relationship: BFO:0000050 GO:0060271 ! part of cilium assembly property_value: RO:0002161 NCBITaxon:3176 property_value: RO:0002161 NCBITaxon:3378 property_value: RO:0002161 NCBITaxon:3398 property_value: RO:0002161 NCBITaxon:4890 property_value: RO:0002161 NCBITaxon:5782 creation_date: 2016-08-05T16:12:33Z [Term] id: GO:0097712 name: vesicle targeting, trans-Golgi to periciliary membrane compartment namespace: biological_process def: "The process in which vesicles formed at the trans-Golgi network are directed to the plasma membrane surrounding the base of the cilium, including the ciliary pocket, mediated by molecules at the vesicle membrane and target membrane surfaces." [GOC:cilia, PMID:20106869, PMID:23351793, PMID:24814148, PMID:26485645] is_a: GO:0048199 ! vesicle targeting, to, from or within Golgi relationship: BFO:0000050 GO:0060271 ! part of cilium assembly property_value: RO:0002161 NCBITaxon:3176 property_value: RO:0002161 NCBITaxon:3378 property_value: RO:0002161 NCBITaxon:3398 property_value: RO:0002161 NCBITaxon:4890 property_value: RO:0002161 NCBITaxon:5782 creation_date: 2016-08-05T16:16:28Z [Term] id: GO:0097719 name: neural tissue regeneration namespace: biological_process def: "The regrowth of neural tissue following its loss or destruction." [Wikipedia:Neuroregeneration] synonym: "neuroregeneration" RELATED [] is_a: GO:0042246 ! tissue regeneration intersection_of: GO:0031099 ! regeneration intersection_of: RO:0002299 UBERON:0003714 ! results in maturation of neural tissue relationship: RO:0002299 UBERON:0003714 ! results in maturation of neural tissue creation_date: 2016-08-25T13:14:27Z [Term] id: GO:0097722 name: sperm motility namespace: biological_process def: "Any process involved in the controlled movement of a sperm cell." [GOC:cilia, GOC:krc] subset: gocheck_do_not_annotate synonym: "sperm movement" EXACT [] is_a: BFO:0000003 is_a: GO:0022414 ! reproductive process is_a: GO:0048870 ! cell motility intersection_of: GO:0048870 ! cell motility intersection_of: RO:0002565 CL:0000019 ! results in movement of sperm relationship: RO:0002565 CL:0000019 ! results in movement of sperm property_value: RO:0002161 NCBITaxon:4890 creation_date: 2016-09-01T12:00:45Z [Term] id: GO:0097729 name: 9+2 motile cilium namespace: cellular_component def: "A motile cilium where the axoneme has a ring of nine outer microtubule doublets plus two central microtubules (and is therefore called a 9+2 axoneme)." [GOC:cilia, PMID:22118931] comment: This type of cilia may be present in solitary (so-called flagella, e.g. in sperm) or in multiple copies (so-called conventional motile cilia, e.g. in tracheal epithelium, ependyma or oviduct epithelium). synonym: "conventional motile cilium" NARROW [] synonym: "motile 9+2 cilium" EXACT [] synonym: "sperm flagellum" NARROW [] is_a: GO:0031514 ! motile cilium relationship: BFO:0000051 GO:0001534 ! has part radial spoke relationship: BFO:0000051 GO:0036156 ! has part inner dynein arm relationship: BFO:0000051 GO:0036157 ! has part outer dynein arm relationship: BFO:0000051 GO:0097540 ! has part axonemal central pair relationship: BFO:0000051 GO:0097545 ! has part axonemal doublet microtubule property_value: RO:0002161 NCBITaxon:3176 property_value: RO:0002161 NCBITaxon:3378 property_value: RO:0002161 NCBITaxon:3398 property_value: RO:0002161 NCBITaxon:4890 property_value: RO:0002161 NCBITaxon:5782 creation_date: 2016-09-27T15:26:34Z [Term] id: GO:0097730 name: non-motile cilium namespace: cellular_component def: "A cilium which may have a variable array of axonemal microtubules but does not contain molecular motors." [GOC:cilia, GOC:dgh, GOC:kmv, PMID:17009929, PMID:20144998, PMID:22118931] synonym: "immotile cilium" EXACT [] synonym: "immotile primary cilium" RELATED [] synonym: "nonmotile cilium" EXACT [] synonym: "nonmotile primary cilia" RELATED [] synonym: "nonmotile primary cilium" RELATED [] synonym: "sensory cilium" RELATED [] is_a: GO:0005929 ! cilium property_value: RO:0002161 NCBITaxon:3176 property_value: RO:0002161 NCBITaxon:3378 property_value: RO:0002161 NCBITaxon:3398 property_value: RO:0002161 NCBITaxon:4890 property_value: RO:0002161 NCBITaxon:5782 creation_date: 2016-09-29T14:02:11Z [Term] id: GO:0097734 name: extracellular exosome biogenesis namespace: biological_process def: "The assembly and secretion of an extracellular exosome, a membrane-bounded vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane." [GOC:bf, GOC:PARL, PMID:19442504, PMID:25392495] synonym: "exosome assembly or secretion" EXACT [] synonym: "exosome biogenesis" EXACT [] synonym: "exosome production" EXACT [] synonym: "ILV assembly" RELATED [] synonym: "intraluminal vesicle assembly" RELATED [] is_a: GO:0140112 ! extracellular vesicle biogenesis creation_date: 2016-10-03T14:35:25Z [Term] id: GO:0097742 name: de novo centriole assembly namespace: biological_process def: "Centriole assembly in which a centriole arises de novo, rather than by replication from an existing centriole. This process may occur via different mechanisms. Examples include the deuterosome pathway in multicilated epithelial animal cells and formation of centrioles during parthenogenesis in some insects." [GOC:cilia, PMID:25047614, PMID:25291643] synonym: "acentriolar basal body biogenesis" RELATED [] synonym: "de novo basal body amplification" RELATED [] synonym: "de novo basal body assembly" RELATED [] synonym: "de novo basal body biogenesis" RELATED [] synonym: "de novo basal body generation" RELATED [] synonym: "de novo centriole amplification" RELATED [] synonym: "de novo ciliary basal body assembly" RELATED [] synonym: "multiciliation" RELATED [] synonym: "multiciliogenesis" RELATED [] is_a: GO:0098534 ! centriole assembly creation_date: 2016-10-19T15:13:50Z [Term] id: GO:0098520 name: excitatory neuromuscular junction namespace: cellular_component def: "The junction between the axon of a motor neuron and a muscle fiber. In response to the arrival of action potentials, the presynaptic button releases molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane of the muscle fiber, leading to a post-synaptic potential responsible for muscle contraction." [GOC:dos] is_a: GO:0031594 ! neuromuscular junction is_a: GO:0060076 ! excitatory synapse intersection_of: GO:0060076 ! excitatory synapse intersection_of: RO:0002131 CL:0000100 ! overlaps motor neuron intersection_of: RO:0002131 CL:0000187 ! overlaps muscle cell creation_date: 2013-10-14T12:02:51Z [Term] id: GO:0098522 name: neuromuscular junction of skeletal muscle fiber namespace: cellular_component def: "A neuromuscular junction in which the target muscle cell is a skeletal muscle fiber." [GOC:dos] comment: In vertebrates, the term 'neuromuscular junction' is limited to synapses targeting skeletal muscle fibers - all of which are cholinergic and excitatory. Both inhibitory and excitatory neuromuscular junctions exist in invertebrates, utilizing a range of neurotransmitters including glutamate, GABA and 5-HT. is_a: GO:0098520 ! excitatory neuromuscular junction is_a: GO:0098523 ! neuromuscular junction of myotube is_a: GO:0098981 ! cholinergic synapse intersection_of: GO:0060076 ! excitatory synapse intersection_of: RO:0002131 CL:0000100 ! overlaps motor neuron intersection_of: RO:0002131 CL:0008002 ! overlaps skeletal muscle fiber relationship: RO:0002131 CL:0008002 ! overlaps skeletal muscle fiber relationship: RO:0002162 NCBITaxon:7742 ! in taxon Vertebrata creation_date: 2013-10-14T12:04:32Z [Term] id: GO:0098523 name: neuromuscular junction of myotube namespace: cellular_component def: "A neuromuscular junction in which the target muscle cell is a myotube." [GOC:dos] comment: In vertebrates, the term 'neuromuscular junction' is limited to synapses targeting the myotubes of skeletal muscle (AKA skeletal muscle fibers). Neuromuscular junctions targeting other muscle cell types exist in invertebrates such as the mononucleate somatic muscles of nematodes. is_a: GO:0031594 ! neuromuscular junction intersection_of: GO:0045202 ! synapse intersection_of: RO:0002131 CL:0000100 ! overlaps motor neuron intersection_of: RO:0002131 CL:0002372 ! overlaps myotube relationship: RO:0002131 CL:0002372 ! overlaps myotube creation_date: 2013-10-14T12:05:12Z [Term] id: GO:0098524 name: neuromuscular junction of somatic muscle myotube namespace: cellular_component def: "A neuromuscular junction in which the target muscle cell is a somatic muscle myotube, such as an arthropod somatic muscle cell." [GOC:dos] is_a: GO:0098523 ! neuromuscular junction of myotube is_a: GO:0098527 ! neuromuscular junction of somatic muscle intersection_of: GO:0045202 ! synapse intersection_of: RO:0002131 CL:0000100 ! overlaps motor neuron intersection_of: RO:0002131 CL:0008003 ! overlaps somatic muscle myotube relationship: RO:0002131 CL:0008003 ! overlaps somatic muscle myotube creation_date: 2013-10-14T12:05:43Z [Term] id: GO:0098525 name: excitatory neuromuscular junction of somatic myotube namespace: cellular_component def: "A neuromuscular junction that functions in the excitation of somatic muscle myotubes, such as an arthropod somatic muscle cells." [GOC:dos] is_a: GO:0098520 ! excitatory neuromuscular junction is_a: GO:0098524 ! neuromuscular junction of somatic muscle myotube intersection_of: GO:0060076 ! excitatory synapse intersection_of: RO:0002131 CL:0000100 ! overlaps motor neuron intersection_of: RO:0002131 CL:0008003 ! overlaps somatic muscle myotube creation_date: 2013-10-14T12:06:08Z [Term] id: GO:0098527 name: neuromuscular junction of somatic muscle namespace: cellular_component def: "A neuromuscular junction in which the target muscle cell is a somatic muscle cell, such as those found in nematodes and arthropods." [GOC:dos] is_a: GO:0031594 ! neuromuscular junction intersection_of: GO:0045202 ! synapse intersection_of: RO:0002131 CL:0000100 ! overlaps motor neuron intersection_of: RO:0002131 CL:0008004 ! overlaps somatic muscle cell relationship: RO:0002131 CL:0008004 ! overlaps somatic muscle cell creation_date: 2013-10-14T12:07:05Z [Term] id: GO:0098528 name: skeletal muscle fiber differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a skeletal muscle fiber cell. Skeletal muscle fiber differentiation starts with myoblast fusion and the appearance of specific cell markers (this is the cell development step). Then individual skeletal muscle fibers fuse to form bigger myotubes and start to contract." [GOC:dos] is_a: GO:0014902 ! myotube differentiation is_a: GO:0035914 ! skeletal muscle cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0008002 ! results in acquisition of features of skeletal muscle fiber relationship: RO:0002315 CL:0008002 ! results in acquisition of features of skeletal muscle fiber creation_date: 2013-10-15T14:00:34Z [Term] id: GO:0098529 name: neuromuscular junction development, skeletal muscle fiber namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a neuromuscular junction that targets a skeletal muscle fiber." [GOC:mtg_OBO2OWL_2013] is_a: GO:0007528 ! neuromuscular junction development intersection_of: GO:0016043 ! cellular component organization intersection_of: RO:0002592 GO:0098522 ! results in organization of neuromuscular junction of skeletal muscle fiber relationship: BFO:0000050 GO:0048741 ! part of skeletal muscle fiber development relationship: RO:0002592 GO:0098522 ! results in organization of neuromuscular junction of skeletal muscle fiber [Term] id: GO:0098534 name: centriole assembly namespace: biological_process def: "A cellular process that results in the assembly of one or more centrioles." [GOC:dos, PMID:24075808] is_a: GO:0031023 ! microtubule organizing center organization is_a: GO:0140694 ! membraneless organelle assembly intersection_of: GO:0022607 ! cellular component assembly intersection_of: RO:0002588 GO:0005814 ! results in assembly of centriole relationship: RO:0002588 GO:0005814 ! results in assembly of centriole creation_date: 2013-10-22T15:55:22Z [Term] id: GO:0098535 name: de novo centriole assembly involved in multi-ciliated epithelial cell differentiation namespace: biological_process def: "Centriole assembly in which a centriole arises de novo by a process involving an electron-dense structure known as a deuterosome, rather than by duplication of an existing centriole, and occurring as part of multi-ciliated epithelial cell differentiation." [GOC:cilia, GOC:dos, PMID:24075808, PMID:5111878, PMID:5661997] comment: In most eukaryotic cells, 'centriole' (GO:0005814) and 'ciliary basal body' (GO:0036064) represent a common entity that cycles through its function in cell division, then ciliogenesis, then cell division again. However, these structures are modified extensively as they transition into each other, and may contain different proteins, specific to each component. synonym: "centriole amplification" RELATED [PMID:24075808] synonym: "de novo centriole assembly" BROAD [] synonym: "de novo centriole assembly via deuterosome" EXACT [] synonym: "deuterosomal basal body biogenesis" RELATED [] synonym: "deuterosome pathway" RELATED [PMID:25047614] synonym: "deuterosome-mediated centriole biogenesis" RELATED [PMID:24075808] synonym: "multiciliation" RELATED [] synonym: "multiciliogenesis" RELATED [] is_a: GO:0097742 ! de novo centriole assembly intersection_of: GO:0097742 ! de novo centriole assembly intersection_of: BFO:0000050 GO:1903251 ! part of multi-ciliated epithelial cell differentiation relationship: BFO:0000050 GO:1903251 ! part of multi-ciliated epithelial cell differentiation relationship: has_participant GO:0098536 ! deuterosome creation_date: 2013-10-22T16:03:13Z [Term] id: GO:0098536 name: deuterosome namespace: cellular_component def: "A spherical, electron dense, cytoplasmic structure that is involved in de novo assembly of centrioles." [GOC:cilia, GOC:dos, PMID:24075808, PMID:25047614, PMID:5661997] is_a: GO:0043232 ! intracellular membraneless organelle relationship: RO:0002162 NCBITaxon:33208 ! in taxon Metazoa creation_date: 2013-10-22T16:21:19Z [Term] id: GO:0098537 name: obsolete lobed nucleus namespace: cellular_component def: "OBSOLETE. Nucleus with two or more lobes connected by a thin filament that contains no internal chromatin. Examples include the nuclei of mature basophils, eosinophils and neutrophils in mice and humans." [GOC:dos, GOC:tfm] comment: This term was obsoleted because it does not correspond to a specific type of nucleus, it is a morphologically different nucleus present in certain cell types. property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/20764" xsd:anyURI is_obsolete: true creation_date: 2013-10-22T18:31:36Z [Term] id: GO:0098542 name: defense response to other organism namespace: biological_process def: "Reactions triggered in response to the presence of another organism that act to protect the cell or organism from damage caused by that organism." [GOC:dos] subset: goslim_generic subset: goslim_prokaryote synonym: "defence response incompatible interaction" NARROW [] synonym: "defence response to pathogen, incompatible interaction" NARROW [] synonym: "defense response, incompatible interaction" NARROW [] synonym: "resistance response to pathogen" NARROW [] is_a: GO:0006952 ! defense response is_a: GO:0051707 ! response to other organism property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/22173" xsd:anyURI property_value: RO:0002161 NCBITaxon:4895 creation_date: 2013-11-11T12:59:11Z [Term] id: GO:0098544 name: maintenance of protein complex location namespace: biological_process def: "Any process in which a protein complex is maintained in a location and prevented from moving elsewhere. These include sequestration, stabilization to prevent transport elsewhere and the active retrieval of protein complexes that move away." [GOC:dos] is_a: BFO:0000003 is_a: GO:0051235 ! maintenance of location intersection_of: GO:0051235 ! maintenance of location intersection_of: RO:0004009 GO:0032991 ! has primary input protein-containing complex relationship: RO:0004009 GO:0032991 ! has primary input protein-containing complex creation_date: 2013-11-15T18:20:16Z [Term] id: GO:0098545 name: maintenance of protein complex location in cytoplasm namespace: biological_process def: "Any process in which a protein complex is maintained in a specific location within the cytoplasm and is prevented from moving elsewhere." [GOC:dos] is_a: GO:0051651 ! maintenance of location in cell is_a: GO:0098544 ! maintenance of protein complex location intersection_of: GO:0098544 ! maintenance of protein complex location intersection_of: BFO:0000066 GO:0005737 ! occurs in cytoplasm intersection_of: RO:0004009 GO:0032991 ! has primary input protein-containing complex relationship: BFO:0000066 GO:0005737 ! occurs in cytoplasm creation_date: 2013-11-15T20:49:15Z [Term] id: GO:0098588 name: bounding membrane of organelle namespace: cellular_component def: "The lipid bilayer that forms the outer-most layer of an organelle." [GOC:dos] comment: Examples include the outer membranes of double membrane bound organelles such as mitochondria as well as the bounding membranes of single-membrane bound organelles such as lysosomes. is_a: GO:0031090 ! organelle membrane intersection_of: GO:0016020 ! membrane intersection_of: RO:0002007 GO:0043226 ! bounding layer of organelle relationship: RO:0002007 GO:0043226 ! bounding layer of organelle creation_date: 2014-02-26T13:41:31Z [Term] id: GO:0098590 name: plasma membrane region namespace: cellular_component def: "A membrane that is a (regional) part of the plasma membrane." [GOC:dos] comment: Note that this term should not be used for direct manual annotation as it should always be possible to choose a more specific subclass. subset: gocheck_do_not_annotate synonym: "region of plasma membrane" EXACT [] is_a: GO:0016020 ! membrane intersection_of: GO:0016020 ! membrane intersection_of: BFO:0000050 GO:0005886 ! part of plasma membrane relationship: BFO:0000050 GO:0005886 ! part of plasma membrane property_value: skos:prefLabel "plasma membrane region" xsd:string creation_date: 2014-03-06T11:55:32Z [Term] id: GO:0098594 name: mucin granule namespace: cellular_component def: "A secretory granule that contains mucin." [PMID:16377632] is_a: GO:0030141 ! secretory granule property_value: RO:0002161 NCBITaxon:4890 creation_date: 2014-03-11T15:59:11Z [Term] id: GO:0098609 name: cell-cell adhesion namespace: biological_process def: "The attachment of one cell to another cell via adhesion molecules." [GOC:dos] synonym: "single organismal cell-cell adhesion" RELATED [] is_a: GO:0007155 ! cell adhesion creation_date: 2014-04-16T13:40:03Z [Term] id: GO:0098631 name: cell adhesion mediator activity namespace: molecular_function def: "The binding by a cell-adhesion protein on a cell surface to an adhesion molecule on another cell surface or an external substrate, to mediate adhesion of the cell to the external substrate or to another cell." [GOC:vw, Wikipedia:Cell_adhesion] subset: goslim_generic subset: goslim_prokaryote synonym: "cell adhesion molecule" EXACT [] synonym: "protein binding involved in cell adhesion" EXACT [] is_a: GO:0050839 ! cell adhesion molecule binding intersection_of: GO:0005488 ! binding intersection_of: BFO:0000050 GO:0007155 ! part of cell adhesion relationship: BFO:0000050 GO:0007155 ! part of cell adhesion property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/22959" xsd:anyURI [Term] id: GO:0098632 name: cell-cell adhesion mediator activity namespace: molecular_function def: "The binding by a cell-adhesion protein on the cell surface to an extracellular matrix component, to mediate adhesion of the cell to another cell." [Wikipedia:Cell_adhesion] synonym: "cell-cell adhesion molecule" EXACT [] synonym: "protein binding involved in cell-cell adhesion" EXACT [] is_a: GO:0098631 ! cell adhesion mediator activity intersection_of: GO:0005515 ! protein binding intersection_of: BFO:0000050 GO:0098609 ! part of cell-cell adhesion relationship: BFO:0000050 GO:0098609 ! part of cell-cell adhesion [Term] id: GO:0098633 name: collagen fibril binding namespace: molecular_function def: "Binding to a collagen fibril." [GOC:dos, PMID:21421911] is_a: GO:0050840 ! extracellular matrix binding intersection_of: GO:0005488 ! binding intersection_of: RO:0004009 GO:0098643 ! has primary input fibrillar collagen relationship: RO:0004009 GO:0098643 ! has primary input fibrillar collagen property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/21211" xsd:anyURI [Term] id: GO:0098635 name: protein complex involved in cell-cell adhesion namespace: cellular_component def: "Any protein complex that is capable of carrying out some part of the process of cell-cell adhesion." [GOC:dos] is_a: GO:0098636 ! protein complex involved in cell adhesion intersection_of: GO:0032991 ! protein-containing complex intersection_of: RO:0002216 GO:0098609 ! capable of part of cell-cell adhesion relationship: RO:0002216 GO:0098609 ! capable of part of cell-cell adhesion [Term] id: GO:0098636 name: protein complex involved in cell adhesion namespace: cellular_component def: "Any protein complex that is capable of carrying out some part of the process of cell adhesion to the cell matrix or to another cell." [GOC:dos] synonym: "cell adhesion complex" RELATED [] is_a: GO:0032991 ! protein-containing complex intersection_of: GO:0032991 ! protein-containing complex intersection_of: RO:0002216 GO:0007155 ! capable of part of cell adhesion relationship: RO:0002216 GO:0007155 ! capable of part of cell adhesion [Term] id: GO:0098641 name: cadherin binding involved in cell-cell adhesion namespace: molecular_function def: "Any cadherin binding that occurs as part of the process of cell-cell adhesion." [GOC:dos] is_a: GO:0045296 ! cadherin binding is_a: GO:0098632 ! cell-cell adhesion mediator activity intersection_of: GO:0045296 ! cadherin binding intersection_of: BFO:0000050 GO:0098609 ! part of cell-cell adhesion [Term] id: GO:0098642 name: network-forming collagen trimer namespace: cellular_component def: "A collagen trimer that forms networks." [PMID:21421911] is_a: BFO:0000004 is_a: GO:0005581 ! collagen trimer intersection_of: GO:0005581 ! collagen trimer intersection_of: BFO:0000050 GO:0098645 ! part of collagen network relationship: BFO:0000050 GO:0098645 ! part of collagen network [Term] id: GO:0098643 name: fibrillar collagen namespace: cellular_component def: "A supramolecular assembly of fibrillar collagen complexes in the form of a long fiber (fibril) with transverse striations (bands)." [GOC:dos, PMID:20386646, PMID:21421911, PMID:29853175] synonym: "banded collagen fibril" EXACT [] is_a: GO:0098644 ! complex of collagen trimers relationship: BFO:0000050 GO:0140152 ! part of collagenous component of interstitial matrix property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/29474" xsd:anyURI property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/30146" xsd:anyURI property_value: skos:prefLabel "fibrillar collagen" xsd:string [Term] id: GO:0098644 name: complex of collagen trimers namespace: cellular_component def: "A complex of collagen trimers such as a fibril or collagen network." [GOC:dos] synonym: "Supramolecular aggregate of collagen" EXACT [PMID:19693541] synonym: "Supramolecular collagen assembly" EXACT [PMID:21421911] is_a: GO:0099080 ! supramolecular complex relationship: BFO:0000050 GO:0031012 ! part of extracellular matrix relationship: BFO:0000051 GO:0005581 ! has part collagen trimer property_value: skos:prefLabel "complex of collagen trimers" xsd:string [Term] id: GO:0098645 name: collagen network namespace: cellular_component def: "A supramolecular complex that consists of collagen triple helices associated to form a network." [GOC:dos, PMID:21421911] is_a: GO:0098644 ! complex of collagen trimers [Term] id: GO:0098655 name: monoatomic cation transmembrane transport namespace: biological_process def: "The process in which a monoatomic cation is transported across a membrane. Monatomic cations (also called simple cations) are positively charged ions consisting of exactly one atom." [GOC:dos, GOC:vw] synonym: "ATP hydrolysis coupled cation transmembrane transport" NARROW [] synonym: "cation transmembrane transport" BROAD [] is_a: GO:0006812 ! monoatomic cation transport is_a: GO:0034220 ! monoatomic ion transmembrane transport intersection_of: GO:0055085 ! transmembrane transport intersection_of: RO:0004009 CHEBI:23906 ! has primary input [Term] id: GO:0098657 name: import into cell namespace: biological_process def: "The directed movement of some substance from outside of a cell into a cell. This may occur via transport across the plasma membrane or via endocytosis." [GOC:dos] synonym: "uptake" BROAD [] is_a: BFO:0000003 is_a: GO:0006810 ! transport intersection_of: GO:0006810 ! transport intersection_of: RO:0002338 GO:0005576 ! has target start location extracellular region intersection_of: RO:0002339 GO:0005737 ! has target end location cytoplasm intersection_of: RO:0004009 CHEBI:24431 ! has primary input relationship: RO:0002338 GO:0005576 ! has target start location extracellular region relationship: RO:0002339 GO:0005737 ! has target end location cytoplasm relationship: RO:0004009 CHEBI:24431 ! has primary input [Term] id: GO:0098658 name: inorganic anion import across plasma membrane namespace: biological_process def: "The directed movement of inorganic anions from outside of a cell, across the plasma membrane and into the cytosol." [GOC:dos] synonym: "inorganic anion import into cell" EXACT [] is_a: GO:0015698 ! inorganic anion transport is_a: GO:0099587 ! inorganic ion import across plasma membrane intersection_of: GO:0006810 ! transport intersection_of: RO:0002338 GO:0005576 ! has target start location extracellular region intersection_of: RO:0002339 GO:0005829 ! has target end location cytosol intersection_of: RO:0002342 GO:0005886 ! results in transport across plasma membrane intersection_of: RO:0004009 CHEBI:24834 ! has primary input [Term] id: GO:0098659 name: inorganic cation import across plasma membrane namespace: biological_process def: "The directed movement of inorganic cations from outside of a cell, across the plasma membrane and into the cytosol." [GOC:dos] synonym: "inorganic cation import into cell" EXACT [] is_a: GO:0099587 ! inorganic ion import across plasma membrane intersection_of: GO:0006810 ! transport intersection_of: RO:0002338 GO:0005576 ! has target start location extracellular region intersection_of: RO:0002339 GO:0005829 ! has target end location cytosol intersection_of: RO:0002342 GO:0005886 ! results in transport across plasma membrane intersection_of: RO:0004009 CHEBI:36915 ! has primary input relationship: RO:0004009 CHEBI:36915 ! has primary input [Term] id: GO:0098664 name: G protein-coupled serotonin receptor signaling pathway namespace: biological_process def: "The series of molecular signals generated as a consequence of a G protein-coupled serotonin receptor binding to one of its physiological ligands." [GOC:mah] synonym: "G-protein coupled serotonin receptor signaling pathway" EXACT [] is_a: GO:0007186 ! G protein-coupled receptor signaling pathway intersection_of: GO:0007165 ! signal transduction intersection_of: RO:0002224 GO:0004993 ! starts with G protein-coupled serotonin receptor activity relationship: RO:0002224 GO:0004993 ! starts with G protein-coupled serotonin receptor activity creation_date: 2016-12-21T12:07:58Z [Term] id: GO:0098665 name: serotonin receptor complex namespace: cellular_component def: "A protein complex that is capable of serotonin receptor activity." [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:16116092] synonym: "5-HT receptor complex" EXACT [] synonym: "5-hydroxytryptamine receptor complex" EXACT [] synonym: "5HT receptor complex" EXACT [] is_a: GO:0043235 ! receptor complex intersection_of: GO:0032991 ! protein-containing complex intersection_of: RO:0002215 GO:0099589 ! capable of serotonin receptor activity relationship: RO:0002215 GO:0099589 ! capable of serotonin receptor activity creation_date: 2016-12-21T12:24:56Z [Term] id: GO:0098666 name: G protein-coupled serotonin receptor complex namespace: cellular_component def: "A protein complex that is capable of G protein-coupled serotonin receptor activity." [GO_REF:0000088, GOC:bhm, GOC:TermGenie] synonym: "G-protein coupled serotonin receptor complex" EXACT [] is_a: GO:0043235 ! receptor complex intersection_of: GO:0032991 ! protein-containing complex intersection_of: RO:0002215 GO:0004993 ! capable of G protein-coupled serotonin receptor activity relationship: RO:0002215 GO:0004993 ! capable of G protein-coupled serotonin receptor activity relationship: RO:0002216 GO:0098664 ! capable of part of G protein-coupled serotonin receptor signaling pathway property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/12942" xsd:anyURI creation_date: 2016-12-21T12:28:12Z [Term] id: GO:0098690 name: glycinergic synapse namespace: cellular_component def: "A synapse that uses glycine as a neurotransmitter." [GOC:dos] subset: goslim_synapse is_a: GO:0045202 ! synapse intersection_of: GO:0045202 ! synapse intersection_of: RO:0002215 GO:0060012 ! capable of synaptic transmission, glycinergic relationship: RO:0002215 GO:0060012 ! capable of synaptic transmission, glycinergic creation_date: 2017-03-07T14:50:33Z [Term] id: GO:0098691 name: dopaminergic synapse namespace: cellular_component def: "A synapse that uses dopamine as a neurotransmitter." [GOC:dos] subset: goslim_synapse is_a: GO:0045202 ! synapse intersection_of: GO:0045202 ! synapse intersection_of: RO:0002215 GO:0001963 ! capable of synaptic transmission, dopaminergic relationship: RO:0002215 GO:0001963 ! capable of synaptic transmission, dopaminergic creation_date: 2017-03-07T14:51:52Z [Term] id: GO:0098693 name: regulation of synaptic vesicle cycle namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the synaptic vesicle cycle." [GOC:dos] subset: goslim_synapse is_a: GO:0060627 ! regulation of vesicle-mediated transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0099504 ! regulates synaptic vesicle cycle relationship: RO:0002211 GO:0099504 ! regulates synaptic vesicle cycle creation_date: 2017-03-21T16:06:48Z [Term] id: GO:0098703 name: calcium ion import across plasma membrane namespace: biological_process def: "The directed movement of calcium ions from outside of a cell, across the plasma membrane and into the cytosol." [GOC:dos] synonym: "calcium ion import into cell" EXACT [] synonym: "calcium ion uptake into cell" EXACT [GOC:vw] is_a: GO:0070509 ! calcium ion import is_a: GO:0097553 ! calcium ion transmembrane import into cytosol is_a: GO:0098659 ! inorganic cation import across plasma membrane is_a: GO:1902656 ! calcium ion import into cytosol intersection_of: GO:0006810 ! transport intersection_of: RO:0002338 GO:0005576 ! has target start location extracellular region intersection_of: RO:0002339 GO:0005829 ! has target end location cytosol intersection_of: RO:0002342 GO:0005886 ! results in transport across plasma membrane intersection_of: RO:0004009 CHEBI:29108 ! has primary input property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/24965" xsd:anyURI creation_date: 2013-02-07T13:07:59Z [Term] id: GO:0098704 name: carbohydrate import across plasma membrane namespace: biological_process def: "The directed movement of a carbohydrate from outside of a cell, across the plasma membrane and into the cytosol." [GOC:dos] synonym: "carbohydrate import into cell" EXACT [] is_a: GO:0034219 ! carbohydrate transmembrane transport is_a: GO:0098739 ! import across plasma membrane intersection_of: GO:0006810 ! transport intersection_of: RO:0002338 GO:0005576 ! has target start location extracellular region intersection_of: RO:0002339 GO:0005829 ! has target end location cytosol intersection_of: RO:0002342 GO:0005886 ! results in transport across plasma membrane intersection_of: RO:0004009 CHEBI:16646 ! has primary input creation_date: 2012-05-31T02:45:02Z [Term] id: GO:0098708 name: D-glucose import across plasma membrane namespace: biological_process def: "The directed movement of D-glucose from outside of a cell, across the plasma membrane and into the cytosol." [GOC:dos] synonym: "glucose import across plasma membrane" EXACT [] synonym: "glucose import into cell" EXACT [] synonym: "high affinity glucose import" NARROW [] is_a: GO:0140271 ! hexose import across plasma membrane is_a: GO:1904659 ! D-glucose transmembrane transport intersection_of: GO:0006810 ! transport intersection_of: RO:0002338 GO:0005576 ! has target start location extracellular region intersection_of: RO:0002339 GO:0005829 ! has target end location cytosol intersection_of: RO:0002342 GO:0005886 ! results in transport across plasma membrane intersection_of: RO:0004009 CHEBI:4167 ! has primary input creation_date: 2012-12-06T14:54:07Z [Term] id: GO:0098711 name: iron ion import across plasma membrane namespace: biological_process def: "The directed movement of iron ions from outside of a cell, across the plasma membrane and into the cytosol." [GOC:mah, PMID:8321236] synonym: "ferrous ion import into cell" RELATED [GOC:mah] synonym: "ferrous iron import across plasma membrane" RELATED [] synonym: "ferrous iron import into cell" RELATED [] synonym: "iron import into cell" RELATED [GOC:mah] synonym: "iron ion import into cell" EXACT [] is_a: GO:0033212 ! iron import into cell is_a: GO:0034755 ! iron ion transmembrane transport is_a: GO:0098659 ! inorganic cation import across plasma membrane intersection_of: GO:0006810 ! transport intersection_of: RO:0002338 GO:0005576 ! has target start location extracellular region intersection_of: RO:0002339 GO:0005829 ! has target end location cytosol intersection_of: RO:0002342 GO:0005886 ! results in transport across plasma membrane intersection_of: RO:0004009 CHEBI:24875 ! has primary input creation_date: 2012-12-20T08:29:00Z [Term] id: GO:0098712 name: L-glutamate import across plasma membrane namespace: biological_process def: "The directed movement of L-glutamate from outside of a cell, across the plasma membrane and into the cytosol." [GOC:dos] synonym: "L-glutamate import into cell" EXACT [] synonym: "L-glutamate(1-) import across plasma membrane" BROAD [] synonym: "L-glutamate(1-) import into cell" EXACT [] is_a: GO:0015813 ! L-glutamate transmembrane transport is_a: GO:0089718 ! amino acid import across plasma membrane intersection_of: GO:0006810 ! transport intersection_of: RO:0002338 GO:0005576 ! has target start location extracellular region intersection_of: RO:0002339 GO:0005829 ! has target end location cytosol intersection_of: RO:0002342 GO:0005886 ! results in transport across plasma membrane intersection_of: RO:0004009 CHEBI:29985 ! has primary input creation_date: 2013-06-12T12:32:47Z [Term] id: GO:0098719 name: sodium ion import across plasma membrane namespace: biological_process def: "The directed movement of sodium ions from outside of a cell, across the plasma membrane and into the cytosol." [GOC:dos] synonym: "sodium import" EXACT [] synonym: "sodium ion import" RELATED [] synonym: "sodium ion import into cell" EXACT [] is_a: GO:0035725 ! sodium ion transmembrane transport is_a: GO:0098659 ! inorganic cation import across plasma membrane intersection_of: GO:0006810 ! transport intersection_of: RO:0002338 GO:0005576 ! has target start location extracellular region intersection_of: RO:0002339 GO:0005829 ! has target end location cytosol intersection_of: RO:0002342 GO:0005886 ! results in transport across plasma membrane intersection_of: RO:0004009 CHEBI:29101 ! has primary input creation_date: 2012-08-03T16:55:52Z [Term] id: GO:0098722 name: asymmetric stem cell division namespace: biological_process def: "Division of a stem cell during which it retains its identity and buds off a daughter cell with a new identity." [GOC:dos, PMID:18513950] is_a: GO:0008356 ! asymmetric cell division is_a: GO:0017145 ! stem cell division intersection_of: GO:0008356 ! asymmetric cell division intersection_of: RO:0004009 CL:0000034 ! has primary input stem cell property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4751 [Term] id: GO:0098723 name: skeletal muscle myofibril namespace: cellular_component def: "A myofibril of a skeletal muscle fiber." [GOC:dos] is_a: GO:0030016 ! myofibril intersection_of: GO:0030016 ! myofibril intersection_of: BFO:0000050 CL:0008002 ! part of skeletal muscle fiber relationship: BFO:0000050 CL:0008002 ! part of skeletal muscle fiber relationship: RO:0002162 NCBITaxon:7742 ! in taxon Vertebrata [Term] id: GO:0098727 name: maintenance of cell number namespace: biological_process def: "Any process by which the numbers of cells of a particular type or in a tissue are maintained." [GOC:dos] is_a: GO:0032502 ! developmental process [Term] id: GO:0098728 name: germline stem cell asymmetric division namespace: biological_process def: "The self-renewing division of a germline stem cell, to produce a daughter stem cell and a daughter germ cell which will divide to form one or more gametes." [GOC:dos] is_a: GO:0042078 ! germ-line stem cell division is_a: GO:0098722 ! asymmetric stem cell division intersection_of: GO:0008356 ! asymmetric cell division intersection_of: RO:0004009 CL:0000014 ! has primary input germ line stem cell property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4751 [Term] id: GO:0098731 name: skeletal muscle satellite stem cell maintenance involved in skeletal muscle regeneration namespace: biological_process def: "Any process by which the number of skeletal muscle satellite stem cells in a skeletal muscle is maintained during skeletal muscle regeneration. There are at least two mechanisms by which this is achieved. Skeletal muscle satellite stem cell asymmetric division ensures satellite stem cell numbers are kept constant. Symmetric division of these cells amplifies the number of skeletal muscle satellite stem cells." [PMID:23303905] is_a: GO:0014834 ! skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration is_a: GO:0035019 ! somatic stem cell population maintenance intersection_of: GO:0098727 ! maintenance of cell number intersection_of: BFO:0000050 GO:0043403 ! part of skeletal muscle tissue regeneration intersection_of: RO:0012003 CL:0008011 ! acts on population of skeletal muscle satellite stem cell relationship: RO:0012003 CL:0008011 ! acts on population of skeletal muscle satellite stem cell [Term] id: GO:0098739 name: import across plasma membrane namespace: biological_process def: "The directed movement of some substance from outside of a cell, across the plasma membrane and into the cytosol." [GOC:dos] synonym: "uptake" BROAD [] is_a: GO:0055085 ! transmembrane transport is_a: GO:0098657 ! import into cell intersection_of: GO:0006810 ! transport intersection_of: RO:0002338 GO:0005576 ! has target start location extracellular region intersection_of: RO:0002339 GO:0005829 ! has target end location cytosol intersection_of: RO:0002342 GO:0005886 ! results in transport across plasma membrane relationship: RO:0002339 GO:0005829 ! has target end location cytosol relationship: RO:0002342 GO:0005886 ! results in transport across plasma membrane [Term] id: GO:0098749 name: cerebellar neuron development namespace: biological_process def: "The process whose specific outcome is the progression of a cerebellar neuron over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell." [GOC:dos] is_a: GO:0021954 ! central nervous system neuron development intersection_of: GO:0032502 ! developmental process intersection_of: RO:0002296 CL:1001611 ! results in development of cerebellar neuron relationship: BFO:0000050 GO:0021549 ! part of cerebellum development relationship: RO:0002296 CL:1001611 ! results in development of cerebellar neuron [Term] id: GO:0098751 name: bone cell development namespace: biological_process def: "The process whose specific outcome is the progression of a bone cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell." [GOC:dos] comment: Not to be used for manual annotation. Please choose a more specific cell development term or if not possible, bone or bone tissue development. subset: gocheck_do_not_annotate is_a: GO:0048468 ! cell development intersection_of: GO:0032502 ! developmental process intersection_of: RO:0002296 CL:0001035 ! results in development of bone cell relationship: BFO:0000050 GO:0060348 ! part of bone development relationship: RO:0002296 CL:0001035 ! results in development of bone cell [Term] id: GO:0098754 name: detoxification namespace: biological_process def: "Any process that reduces or removes the toxicity of a toxic substance. These may include transport of the toxic substance away from sensitive areas and to compartments or complexes whose purpose is sequestration of the toxic substance." [GOC:dos] subset: goslim_euk_cellular_processes_ribbon subset: goslim_generic subset: goslim_pombe subset: goslim_prokaryote subset: goslim_prokaryote_ribbon is_a: GO:0008150 ! biological_process relationship: BFO:0000050 GO:0009636 ! part of response to toxic substance [Term] id: GO:0098771 name: inorganic ion homeostasis namespace: biological_process def: "Any process involved in the maintenance of an internal steady state of inorganic ions within an organism or cell." [GOC:dos] subset: goslim_pombe is_a: GO:0048878 ! chemical homeostasis intersection_of: GO:0042592 ! homeostatic process intersection_of: RO:0002332 CHEBI:36914 ! regulates levels of relationship: RO:0002332 CHEBI:36914 ! regulates levels of property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/24455" xsd:anyURI [Term] id: GO:0098773 name: skin epidermis development namespace: biological_process def: "The process whose specific outcome is the progression of the skin epidermis over time, from its formation to the mature structure." [GOC:dos] is_a: GO:0008544 ! epidermis development is_a: GO:0060429 ! epithelium development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0001003 ! results in development of skin epidermis relationship: BFO:0000050 GO:0043588 ! part of skin development relationship: RO:0002296 UBERON:0001003 ! results in development of skin epidermis [Term] id: GO:0098793 name: presynapse namespace: cellular_component def: "The part of a synapse that is part of the presynaptic cell." [GOC:dos] subset: goslim_synapse synonym: "presynaptic terminal" EXACT [] is_a: GO:0110165 ! cellular anatomical structure relationship: BFO:0000050 CL:0000540 ! part of neuron relationship: BFO:0000050 GO:0045202 ! part of synapse relationship: RO:0002162 NCBITaxon:6072 ! in taxon Eumetazoa [Term] id: GO:0098794 name: postsynapse namespace: cellular_component def: "The part of a synapse that is part of the post-synaptic cell." [GOC:dos] subset: goslim_synapse is_a: GO:0110165 ! cellular anatomical structure relationship: BFO:0000050 CL:0000000 ! part of cell relationship: BFO:0000050 GO:0045202 ! part of synapse [Term] id: GO:0098796 name: membrane protein complex namespace: cellular_component def: "Any protein complex that is part of a membrane." [GOC:dos] subset: goslim_metagenomics is_a: BFO:0000004 is_a: GO:0032991 ! protein-containing complex intersection_of: GO:0032991 ! protein-containing complex intersection_of: BFO:0000050 GO:0016020 ! part of membrane relationship: BFO:0000050 GO:0016020 ! part of membrane [Term] id: GO:0098797 name: plasma membrane protein complex namespace: cellular_component def: "Any protein complex that is part of the plasma membrane." [GOC:dos] is_a: GO:0098796 ! membrane protein complex intersection_of: GO:0032991 ! protein-containing complex intersection_of: BFO:0000050 GO:0005886 ! part of plasma membrane relationship: BFO:0000050 GO:0005886 ! part of plasma membrane [Term] id: GO:0098798 name: mitochondrial protein-containing complex namespace: cellular_component def: "A protein complex that is part of a mitochondrion." [GOC:dos] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_annotate synonym: "mitochondrial protein complex" RELATED [] is_a: BFO:0000004 is_a: GO:0032991 ! protein-containing complex intersection_of: GO:0032991 ! protein-containing complex intersection_of: BFO:0000050 GO:0005739 ! part of mitochondrion relationship: BFO:0000050 GO:0005739 ! part of mitochondrion [Term] id: GO:0098799 name: outer mitochondrial membrane protein complex namespace: cellular_component def: "Any protein complex that is part of the outer mitochondrial membrane." [GOC:dos] is_a: GO:0098796 ! membrane protein complex is_a: GO:0098798 ! mitochondrial protein-containing complex intersection_of: GO:0032991 ! protein-containing complex intersection_of: BFO:0000050 GO:0005741 ! part of mitochondrial outer membrane relationship: BFO:0000050 GO:0005741 ! part of mitochondrial outer membrane [Term] id: GO:0098801 name: regulation of renal system process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of a system process, a multicellular organismal process carried out by the renal system." [GOC:dos] is_a: GO:0044057 ! regulation of system process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0003014 ! regulates renal system process relationship: RO:0002211 GO:0003014 ! regulates renal system process property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0098802 name: plasma membrane signaling receptor complex namespace: cellular_component def: "Any protein complex that is part of the plasma membrane and which functions as a signaling receptor." [GOC:dos] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_annotate is_a: GO:0043235 ! receptor complex is_a: GO:0098797 ! plasma membrane protein complex intersection_of: GO:0032991 ! protein-containing complex intersection_of: BFO:0000050 GO:0005886 ! part of plasma membrane intersection_of: RO:0002215 GO:0038023 ! capable of signaling receptor activity [Term] id: GO:0098804 name: non-motile cilium membrane namespace: cellular_component def: "The portion of the plasma membrane surrounding a non-motile cilium." [GOC:cilia, GOC:dos] synonym: "nonmotile primary cilium membrane" RELATED [] is_a: GO:0060170 ! ciliary membrane intersection_of: GO:0016020 ! membrane intersection_of: RO:0002007 GO:0097730 ! bounding layer of non-motile cilium relationship: RO:0002007 GO:0097730 ! bounding layer of non-motile cilium property_value: RO:0002161 NCBITaxon:3176 property_value: RO:0002161 NCBITaxon:3378 property_value: RO:0002161 NCBITaxon:3398 property_value: RO:0002161 NCBITaxon:4890 property_value: RO:0002161 NCBITaxon:5782 [Term] id: GO:0098813 name: nuclear chromosome segregation namespace: biological_process def: "The process in which genetic material, in the form of nuclear chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets. Nuclear chromosome segregation begins with the condensation of chromosomes, includes chromosome separation, and ends when chromosomes have completed movement to the spindle poles." [GOC:dos] is_a: GO:0007059 ! chromosome segregation [Term] id: GO:0098815 name: modulation of excitatory postsynaptic potential namespace: biological_process def: "Any process that modulates the frequency, rate or extent of excitatory postsynaptic potential (EPSP). EPSP is a process that leads to a temporary increase in postsynaptic potential due to the flow of positively charged ions into the postsynaptic cell. The flow of ions that causes an EPSP is an excitatory postsynaptic current (EPSC) and makes it easier for the neuron to fire an action potential." [GOC:dos] is_a: GO:0009966 ! regulation of signal transduction is_a: GO:0031644 ! regulation of nervous system process is_a: GO:0042391 ! regulation of membrane potential is_a: GO:0050804 ! modulation of chemical synaptic transmission intersection_of: GO:0050789 ! regulation of biological process intersection_of: RO:0002211 GO:0060079 ! regulates excitatory postsynaptic potential relationship: RO:0002211 GO:0060079 ! regulates excitatory postsynaptic potential [Term] id: GO:0098840 name: protein transport along microtubule namespace: biological_process def: "The directed movement of a protein along a microtubule, mediated by motor proteins." [PMID:25987607] synonym: "microtubule-based protein transport" BROAD [] is_a: GO:0006886 ! intracellular protein transport is_a: GO:0010970 ! transport along microtubule is_a: GO:0099118 ! microtubule-based protein transport intersection_of: GO:0046907 ! intracellular transport intersection_of: RO:0002341 GO:0005874 ! results in transport along microtubule intersection_of: RO:0004009 PR:000000001 ! has primary input protein [Term] id: GO:0098852 name: lytic vacuole membrane namespace: cellular_component def: "The lipid bilayer surrounding a lytic vacuole and separating its contents from the cytoplasm of the cell." [GOC:dos] is_a: GO:0005774 ! vacuolar membrane intersection_of: GO:0016020 ! membrane intersection_of: RO:0002007 GO:0000323 ! bounding layer of lytic vacuole relationship: RO:0002007 GO:0000323 ! bounding layer of lytic vacuole [Term] id: GO:0098858 name: actin-based cell projection namespace: cellular_component def: "A cell projection supported by an assembly of actin filaments, and which lacks microtubules." [PMID:15661519] is_a: GO:0120025 ! plasma membrane bounded cell projection relationship: BFO:0000051 GO:0005884 ! has part actin filament [Term] id: GO:0098862 name: cluster of actin-based cell projections namespace: cellular_component def: "A cell part consisting of multiple, closely packed actin-based cell projections." [GOC:dos] is_a: GO:0110165 ! cellular anatomical structure relationship: BFO:0000050 CL:0000000 ! part of cell relationship: BFO:0000051 GO:0098858 ! has part actin-based cell projection [Term] id: GO:0098867 name: intramembranous bone growth namespace: biological_process def: "The increase in size or mass of an intramembranous bone that contributes to the shaping of the bone." [PMID:26399686] is_a: GO:0098868 ! bone growth intersection_of: GO:0048589 ! developmental growth intersection_of: RO:0002343 UBERON:0002514 ! results in growth of intramembranous bone relationship: RO:0002343 UBERON:0002514 ! results in growth of intramembranous bone [Term] id: GO:0098868 name: bone growth namespace: biological_process def: "The increase in size or mass of a bone that contributes to the shaping of that bone." [GOC:dos] is_a: GO:0035265 ! organ growth intersection_of: GO:0048589 ! developmental growth intersection_of: RO:0002343 UBERON:0001474 ! results in growth of bone element relationship: BFO:0000050 GO:0060348 ! part of bone development relationship: RO:0002343 UBERON:0001474 ! results in growth of bone element [Term] id: GO:0098871 name: postsynaptic actin cytoskeleton namespace: cellular_component def: "The actin cytoskeleton that is part of a postsynapse." [GOC:dos] subset: goslim_synapse is_a: GO:0015629 ! actin cytoskeleton is_a: GO:0099571 ! postsynaptic cytoskeleton intersection_of: GO:0015629 ! actin cytoskeleton intersection_of: BFO:0000050 GO:0098794 ! part of postsynapse [Term] id: GO:0098876 name: vesicle-mediated transport to the plasma membrane namespace: biological_process def: "The directed movement of substances to the plasma membrane in transport vesicles that fuse with the plasma membrane by exocytosis." [GOC:dos] is_a: BFO:0000003 is_a: GO:0016192 ! vesicle-mediated transport is_a: GO:0051668 ! localization within membrane intersection_of: GO:0006810 ! transport intersection_of: RO:0002339 GO:0005886 ! has target end location plasma membrane intersection_of: RO:0002608 GO:0031982 ! process has causal agent vesicle relationship: RO:0002230 GO:0006887 ! ends with exocytosis relationship: RO:0002339 GO:0005886 ! has target end location plasma membrane [Term] id: GO:0098877 name: neurotransmitter receptor transport to plasma membrane namespace: biological_process def: "The directed movement of neurotransmitter receptor to the plasma membrane in transport vesicles." [GOC:dos] subset: goslim_synapse is_a: GO:0072657 ! protein localization to membrane is_a: GO:0090150 ! establishment of protein localization to membrane is_a: GO:0098876 ! vesicle-mediated transport to the plasma membrane is_a: GO:0099637 ! neurotransmitter receptor transport is_a: GO:1990778 ! protein localization to cell periphery intersection_of: GO:0015031 ! protein transport intersection_of: RO:0002339 GO:0005886 ! has target end location plasma membrane intersection_of: RO:0004009 GO:0098878 ! has primary input neurotransmitter receptor complex [Term] id: GO:0098878 name: neurotransmitter receptor complex namespace: cellular_component def: "Any protein complex that is capable of functioning as a neurotransmitter receptor." [GOC:dos] is_a: GO:0098802 ! plasma membrane signaling receptor complex intersection_of: GO:0032991 ! protein-containing complex intersection_of: RO:0002215 GO:0030594 ! capable of neurotransmitter receptor activity relationship: RO:0002215 GO:0030594 ! capable of neurotransmitter receptor activity [Term] id: GO:0098883 name: synapse pruning namespace: biological_process def: "A cellular process that results in the controlled breakdown of synapse. After it starts the process is continuous until the synapse has disappeared." [GOC:dos, PMID:12062020, PMID:18083105, PMID:22632716, PMID:29844190] subset: goslim_synapse synonym: "synapse clearance" EXACT [GOC:aruk, GOC:bc, PMID:22632716] synonym: "synapse disassembly" EXACT syngo_official_label [PMID:12062020] synonym: "synapse elimination" EXACT [GOC:aruk, GOC:bc, PMID:18083105, PMID:29844190] synonym: "synapse removal" EXACT [GOC:aruk, GOC:bc, PMID:22632716] is_a: GO:0050808 ! synapse organization is_a: GO:0150146 ! cell junction disassembly intersection_of: GO:0022411 ! cellular component disassembly intersection_of: RO:0002590 GO:0045202 ! results in disassembly of synapse relationship: RO:0002590 GO:0045202 ! results in disassembly of synapse [Term] id: GO:0098900 name: regulation of action potential namespace: biological_process def: "Any process that modulates the frequency, rate or extent of action potential creation, propagation or termination. This typically occurs via modulation of the activity or expression of voltage-gated ion channels." [GOC:dos, GOC:dph, GOC:go_curators, GOC:tb, ISBN:978-0-07-139011-8] comment: The ion channels through which current flows during an action potential should be annotated to the process 'action potential'. Gene products involved in modulating the characteristics of an action potential via changing the expression levels or the activity of these channels (e.g. modulating their kinetics or voltage sensitivity) should be annotated to this regulation term. is_a: GO:0042391 ! regulation of membrane potential is_a: GO:0050789 ! regulation of biological process intersection_of: GO:0050789 ! regulation of biological process intersection_of: RO:0002211 GO:0001508 ! regulates action potential relationship: RO:0002211 GO:0001508 ! regulates action potential property_value: RO:0002161 NCBITaxon:4895 [Term] id: GO:0098901 name: regulation of cardiac muscle cell action potential namespace: biological_process def: "Any process that modulates the frequency, rate or extent of action potential creation, propagation or termination in a cardiac muscle cell. This typically occurs via modulation of the activity or expression of voltage-gated ion channels." [GOC:dos, GOC:mtg_cardiac_conduct_nov11] is_a: GO:0098900 ! regulation of action potential intersection_of: GO:0050789 ! regulation of biological process intersection_of: RO:0002211 GO:0086001 ! regulates cardiac muscle cell action potential relationship: RO:0002211 GO:0086001 ! regulates cardiac muscle cell action potential property_value: RO:0002161 NCBITaxon:4895 [Term] id: GO:0098902 name: regulation of membrane depolarization during action potential namespace: biological_process def: "Any process that modulates the rate, frequency or extent of membrane depolarization during an action potential. Membrane depolarization is the process in which membrane potential changes in the depolarizing direction from the resting potential." [GOC:dos, GOC:dph, GOC:tb, ISBN:978-0-07-139011-8] is_a: GO:0003254 ! regulation of membrane depolarization intersection_of: GO:0050789 ! regulation of biological process intersection_of: RO:0002211 GO:0086010 ! regulates membrane depolarization during action potential relationship: RO:0002211 GO:0086010 ! regulates membrane depolarization during action potential property_value: RO:0002161 NCBITaxon:4895 [Term] id: GO:0098903 name: regulation of membrane repolarization during action potential namespace: biological_process def: "Any process that modulates the rate, frequency or extent of membrane repolarization during an action potential. Membrane repolarization is the process in which membrane potential changes in the repolarizing direction, towards the resting potential." [GOC:dos, GOC:dph, GOC:tb, ISBN:978-0-07-139011-8] is_a: GO:0060306 ! regulation of membrane repolarization is_a: GO:0098900 ! regulation of action potential intersection_of: GO:0050789 ! regulation of biological process intersection_of: RO:0002211 GO:0086011 ! regulates membrane repolarization during action potential relationship: RO:0002211 GO:0086011 ! regulates membrane repolarization during action potential property_value: RO:0002161 NCBITaxon:4895 [Term] id: GO:0098904 name: regulation of AV node cell action potential namespace: biological_process def: "Any process that modulates the frequency, rate or extent of action potential creation, propagation or termination in an atrioventricular node myocyte. This typically occurs via modulation of the activity or expression of voltage-gated ion channels." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] synonym: "regulation of atrioventricular node cardiac muscle cell action potential" EXACT [] synonym: "regulation of AV node cardiac muscle cell action potential" EXACT [] is_a: GO:0010646 ! regulation of cell communication is_a: GO:0098901 ! regulation of cardiac muscle cell action potential intersection_of: GO:0050789 ! regulation of biological process intersection_of: RO:0002211 GO:0086016 ! regulates AV node cell action potential relationship: RO:0002211 GO:0086016 ! regulates AV node cell action potential property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4895 property_value: RO:0002161 NCBITaxon:4932 creation_date: 2011-11-10T08:58:56Z [Term] id: GO:0098905 name: regulation of bundle of His cell action potential namespace: biological_process def: "Any process that modulates the frequency, rate or extent of action potential creation, propagation or termination in a cardiac muscle cell of the bundle of His. This typically occurs via modulation of the activity or expression of voltage-gated ion channels." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] synonym: "regulation of bundle of His cardiac muscle cell action potential" EXACT [] is_a: GO:0098901 ! regulation of cardiac muscle cell action potential intersection_of: GO:0050789 ! regulation of biological process intersection_of: RO:0002211 GO:0086043 ! regulates bundle of His cell action potential relationship: RO:0002211 GO:0086043 ! regulates bundle of His cell action potential property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4895 property_value: RO:0002161 NCBITaxon:4932 creation_date: 2011-11-15T12:01:18Z [Term] id: GO:0098906 name: regulation of Purkinje myocyte action potential namespace: biological_process def: "Any process that modulates the frequency, rate or extent of action potential creation, propagation or termination in a Purkinje myocyte. This typically occurs via modulation of the activity or expression of voltage-gated ion channels." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] is_a: GO:0010646 ! regulation of cell communication is_a: GO:0098901 ! regulation of cardiac muscle cell action potential intersection_of: GO:0050789 ! regulation of biological process intersection_of: RO:0002211 GO:0086017 ! regulates Purkinje myocyte action potential relationship: RO:0002211 GO:0086017 ! regulates Purkinje myocyte action potential property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4895 property_value: RO:0002161 NCBITaxon:4932 creation_date: 2011-11-10T08:58:56Z [Term] id: GO:0098907 name: regulation of SA node cell action potential namespace: biological_process def: "Any process that modulates the frequency, rate or extent of action potential creation, propagation or termination in an SA node cardiac myocyte. This typically occurs via modulation of the activity or expression of voltage-gated ion channels." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] synonym: "regulation of SA node cardiac muscle cell action potential" EXACT [] synonym: "regulation of SAN cardiac muscle cell action potential" EXACT [] synonym: "regulation of sinoatrial node cardiac muscle cell action potential" EXACT [] synonym: "regulation of sinus node cardiac muscle cell action potential" NARROW [] is_a: GO:0010646 ! regulation of cell communication is_a: GO:0098901 ! regulation of cardiac muscle cell action potential intersection_of: GO:0050789 ! regulation of biological process intersection_of: RO:0002211 GO:0086015 ! regulates SA node cell action potential relationship: RO:0002211 GO:0086015 ! regulates SA node cell action potential property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4895 property_value: RO:0002161 NCBITaxon:4932 creation_date: 2011-11-10T08:50:15Z [Term] id: GO:0098908 name: regulation of neuronal action potential namespace: biological_process def: "Any process that modulates the frequency, rate or extent of action potential creation, propagation or termination in a neuron. This typically occurs via modulation of the activity or expression of voltage-gated ion channels." [GOC:dph, GOC:isa_complete, GOC:tb] synonym: "generation of action potential" RELATED [GOC:dph, GOC:tb] is_a: GO:0051969 ! regulation of transmission of nerve impulse is_a: GO:0098900 ! regulation of action potential intersection_of: GO:0050789 ! regulation of biological process intersection_of: RO:0002211 GO:0019228 ! regulates neuronal action potential relationship: RO:0002211 GO:0019228 ! regulates neuronal action potential [Term] id: GO:0098909 name: regulation of cardiac muscle cell action potential involved in regulation of contraction namespace: biological_process def: "Any process that modulates the frequency, rate or extent of action potential creation, propagation or termination in a cardiac muscle cell contributing to the regulation of its contraction." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] is_a: GO:0098901 ! regulation of cardiac muscle cell action potential intersection_of: GO:0065007 ! biological regulation intersection_of: BFO:0000050 GO:0086004 ! part of regulation of cardiac muscle cell contraction intersection_of: RO:0002211 GO:0086001 ! regulates cardiac muscle cell action potential relationship: BFO:0000050 GO:0086004 ! part of regulation of cardiac muscle cell contraction property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4895 property_value: RO:0002161 NCBITaxon:4932 creation_date: 2011-11-10T07:45:11Z [Term] id: GO:0098910 name: regulation of atrial cardiac muscle cell action potential namespace: biological_process def: "Any process that modulates the frequency, rate or extent of action potential creation, propagation or termination in an atrial cardiac muscle cell contributing to the regulation of its contraction. This typically occurs via modulation of the activity or expression of voltage-gated ion channels." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] is_a: GO:0086004 ! regulation of cardiac muscle cell contraction is_a: GO:0098901 ! regulation of cardiac muscle cell action potential is_a: GO:1903779 ! regulation of cardiac conduction intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0086014 ! regulates atrial cardiac muscle cell action potential relationship: RO:0002211 GO:0086014 ! regulates atrial cardiac muscle cell action potential property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4895 property_value: RO:0002161 NCBITaxon:4932 creation_date: 2011-11-10T08:49:13Z [Term] id: GO:0098911 name: regulation of ventricular cardiac muscle cell action potential namespace: biological_process def: "Any process that modulates the frequency, rate or extent of action potential creation, propagation or termination in a ventricular cardiac muscle cell contributing to the regulation of its contraction. This typically occurs via modulation of the activity or expression of voltage-gated ion channels." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] is_a: GO:0086004 ! regulation of cardiac muscle cell contraction is_a: GO:0098901 ! regulation of cardiac muscle cell action potential intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0086005 ! regulates ventricular cardiac muscle cell action potential relationship: RO:0002211 GO:0086005 ! regulates ventricular cardiac muscle cell action potential property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4895 property_value: RO:0002161 NCBITaxon:4932 creation_date: 2011-11-10T07:59:36Z [Term] id: GO:0098912 name: membrane depolarization during atrial cardiac muscle cell action potential namespace: biological_process def: "The process in which atrial cardiac muscle cell membrane potential changes in the depolarizing direction from the negative resting potential towards the positive membrane potential that will be the peak of the action potential." [GOC:dph, GOC:mtg_cardiac_conduct_nov11, GOC:tb] synonym: "atrial cardiac muscle cell depolarization" BROAD [GOC:dph, GOC:tb] synonym: "atrial depolarization" RELATED [GOC:dph, GOC:tb] synonym: "electrocardiogram PR interval" RELATED [GOC:dph, GOC:tb] is_a: GO:0086012 ! membrane depolarization during cardiac muscle cell action potential intersection_of: GO:0051899 ! membrane depolarization intersection_of: BFO:0000050 GO:0086014 ! part of atrial cardiac muscle cell action potential relationship: BFO:0000050 GO:0086014 ! part of atrial cardiac muscle cell action potential property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4895 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0098913 name: membrane depolarization during ventricular cardiac muscle cell action potential namespace: biological_process def: "The process in which ventricular cardiac muscle cell membrane potential changes in the depolarizing direction from the negative resting potential towards the positive membrane potential that will be the peak of the action potential." [GOC:dph, GOC:mtg_cardiac_conduct_nov11, GOC:tb] synonym: "electrocardiogram QRS complex" RELATED [GOC:dph, GOC:tb] synonym: "ventricular depolarization" RELATED [GOC:dph, GOC:tb] is_a: GO:0086012 ! membrane depolarization during cardiac muscle cell action potential intersection_of: GO:0051899 ! membrane depolarization intersection_of: BFO:0000050 GO:0086005 ! part of ventricular cardiac muscle cell action potential relationship: BFO:0000050 GO:0086005 ! part of ventricular cardiac muscle cell action potential property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4895 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0098914 name: membrane repolarization during atrial cardiac muscle cell action potential namespace: biological_process def: "The process in which ions are transported across a membrane such that the atrial cardiomyocyte membrane potential changes in the direction from the positive membrane potential at the peak of the action potential towards the negative resting potential." [GOC:dph, GOC:mtg_cardiac_conduct_nov11, GOC:tb] synonym: "atrial repolarization" RELATED [GOC:dph, GOC:tb] synonym: "electrocardiogram QRS complex" RELATED [GOC:dph, GOC:tb] is_a: GO:0086013 ! membrane repolarization during cardiac muscle cell action potential is_a: GO:0099624 ! atrial cardiac muscle cell membrane repolarization intersection_of: GO:0086009 ! membrane repolarization intersection_of: BFO:0000050 GO:0086014 ! part of atrial cardiac muscle cell action potential relationship: BFO:0000050 GO:0086014 ! part of atrial cardiac muscle cell action potential [Term] id: GO:0098915 name: membrane repolarization during ventricular cardiac muscle cell action potential namespace: biological_process def: "The process in which ions are transported across a membrane such that the ventricular cardiomyocyte membrane potential changes in the direction from the positive membrane potential at the peak of the action potential towards the negative resting potential." [GOC:BHF, GOC:dph, GOC:mtg_cardiac_conduct_nov11, GOC:tb] synonym: "electrocardiogram T wave" RELATED [GOC:dph, GOC:tb] synonym: "regulation of ventricular cardiac muscle repolarization" RELATED [GOC:dph, GOC:tb] synonym: "ventricular repolarization" RELATED [GOC:dph, GOC:tb] is_a: GO:0086013 ! membrane repolarization during cardiac muscle cell action potential is_a: GO:0099625 ! ventricular cardiac muscle cell membrane repolarization intersection_of: GO:0086009 ! membrane repolarization intersection_of: BFO:0000050 GO:0086005 ! part of ventricular cardiac muscle cell action potential relationship: BFO:0000050 GO:0086005 ! part of ventricular cardiac muscle cell action potential [Term] id: GO:0098916 name: anterograde trans-synaptic signaling namespace: biological_process def: "Cell-cell signaling from pre to post-synapse, across the synaptic cleft." [GOC:dos] is_a: GO:0099537 ! trans-synaptic signaling intersection_of: GO:0099537 ! trans-synaptic signaling intersection_of: RO:0002231 GO:0098793 ! has start location presynapse intersection_of: RO:0002232 GO:0098794 ! has end location postsynapse relationship: RO:0002231 GO:0098793 ! has start location presynapse relationship: RO:0002232 GO:0098794 ! has end location postsynapse [Term] id: GO:0098917 name: retrograde trans-synaptic signaling namespace: biological_process def: "Cell-cell signaling from post to pre-synapse, across the synaptic cleft." [GOC:dos] is_a: GO:0099537 ! trans-synaptic signaling intersection_of: GO:0099537 ! trans-synaptic signaling intersection_of: RO:0002231 GO:0098794 ! has start location postsynapse intersection_of: RO:0002232 GO:0098793 ! has end location presynapse relationship: RO:0002231 GO:0098794 ! has start location postsynapse relationship: RO:0002232 GO:0098793 ! has end location presynapse [Term] id: GO:0098920 name: retrograde trans-synaptic signaling by lipid namespace: biological_process def: "Cell-cell signaling from postsynapse to presynapse, across the synaptic cleft, mediated by a lipid ligand." [GOC:dos] subset: goslim_synapse is_a: GO:0098917 ! retrograde trans-synaptic signaling is_a: GO:0099541 ! trans-synaptic signaling by lipid intersection_of: GO:0099537 ! trans-synaptic signaling intersection_of: RO:0002231 GO:0098794 ! has start location postsynapse intersection_of: RO:0002232 GO:0098793 ! has end location presynapse intersection_of: RO:0002608 CHEBI:18059 ! process has causal agent [Term] id: GO:0098923 name: retrograde trans-synaptic signaling by soluble gas namespace: biological_process def: "Cell-cell signaling from postsynapse to presynapse, across the synaptic cleft, mediated by an soluble gas ligand." [GOC:dos] subset: goslim_synapse is_a: GO:0098917 ! retrograde trans-synaptic signaling is_a: GO:0099543 ! trans-synaptic signaling by soluble gas intersection_of: GO:0099543 ! trans-synaptic signaling by soluble gas intersection_of: RO:0002231 GO:0098794 ! has start location postsynapse intersection_of: RO:0002232 GO:0098793 ! has end location presynapse [Term] id: GO:0098924 name: retrograde trans-synaptic signaling by nitric oxide namespace: biological_process def: "Cell-cell signaling from postsynapse to presynapse, across the synaptic cleft, mediated by nitric oxide." [GOC:dos] subset: goslim_synapse is_a: GO:0098923 ! retrograde trans-synaptic signaling by soluble gas is_a: GO:0099548 ! trans-synaptic signaling by nitric oxide intersection_of: GO:0099537 ! trans-synaptic signaling intersection_of: RO:0002231 GO:0098794 ! has start location postsynapse intersection_of: RO:0002232 GO:0098793 ! has end location presynapse intersection_of: RO:0002608 CHEBI:16480 ! process has causal agent [Term] id: GO:0098925 name: retrograde trans-synaptic signaling by nitric oxide, modulating synaptic transmission namespace: biological_process def: "Modulation of synaptic transmission by cell-cell signaling from postsynapse to presynapse, across the synaptic cleft, mediated by nitric oxide." [GOC:dos] comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. subset: goslim_synapse is_a: GO:0098924 ! retrograde trans-synaptic signaling by nitric oxide is_a: GO:0099555 ! trans-synaptic signaling by nitric oxide, modulating synaptic transmission intersection_of: GO:0099537 ! trans-synaptic signaling intersection_of: RO:0002211 GO:0007268 ! regulates chemical synaptic transmission intersection_of: RO:0002231 GO:0098794 ! has start location postsynapse intersection_of: RO:0002232 GO:0098793 ! has end location presynapse intersection_of: RO:0002608 CHEBI:16480 ! process has causal agent [Term] id: GO:0098926 name: postsynaptic signal transduction namespace: biological_process def: "Signal transduction in which the initial step occurs in a postsynapse." [GOC:dos] subset: goslim_synapse synonym: "postsynaptic signaling pathway" EXACT syngo_official_label [] is_a: GO:0007165 ! signal transduction intersection_of: GO:0007165 ! signal transduction intersection_of: RO:0002231 GO:0098794 ! has start location postsynapse relationship: BFO:0000050 GO:0099536 ! part of synaptic signaling relationship: RO:0002231 GO:0098794 ! has start location postsynapse [Term] id: GO:0098928 name: presynaptic signal transduction namespace: biological_process def: "Signal transduction in which the initial step occurs in a presynapse." [GOC:dos] subset: goslim_synapse synonym: "presynaptic signaling pathway" EXACT syngo_official_label [] is_a: GO:0007165 ! signal transduction intersection_of: GO:0007165 ! signal transduction intersection_of: RO:0002231 GO:0098793 ! has start location presynapse relationship: RO:0002231 GO:0098793 ! has start location presynapse [Term] id: GO:0098930 name: axonal transport namespace: biological_process def: "The directed movement of organelles or molecules along microtubules in axons." [ISBN:0815316194] subset: goslim_synapse synonym: "axon cargo transport" EXACT [] synonym: "axoplasmic transport" EXACT [] xref: Wikipedia:Axoplasmic_transport is_a: GO:0008088 ! axo-dendritic transport intersection_of: GO:0046907 ! intracellular transport intersection_of: BFO:0000066 GO:0030424 ! occurs in axon intersection_of: RO:0002341 GO:0005874 ! results in transport along microtubule relationship: BFO:0000066 GO:0030424 ! occurs in axon [Term] id: GO:0098934 name: retrograde dendritic transport namespace: biological_process def: "The directed movement of organelles or molecules along microtubules in a dendrite from the postsynapse towards the cell body." [GOC:dos] subset: goslim_synapse is_a: GO:0098935 ! dendritic transport intersection_of: GO:0006810 ! transport intersection_of: BFO:0000066 GO:0032839 ! occurs in dendrite cytoplasm intersection_of: RO:0002338 GO:0098793 ! has target start location presynapse intersection_of: RO:0002341 GO:0005874 ! results in transport along microtubule relationship: BFO:0000066 GO:0032839 ! occurs in dendrite cytoplasm relationship: RO:0002338 GO:0098793 ! has target start location presynapse [Term] id: GO:0098935 name: dendritic transport namespace: biological_process def: "The directed movement of organelles or molecules along microtubules in dendrites." [ISBN:0815316194] subset: goslim_synapse synonym: "dendrite cargo transport" EXACT [] is_a: GO:0008088 ! axo-dendritic transport intersection_of: GO:0046907 ! intracellular transport intersection_of: BFO:0000066 GO:0030425 ! occurs in dendrite intersection_of: RO:0002341 GO:0005874 ! results in transport along microtubule relationship: BFO:0000066 GO:0030425 ! occurs in dendrite [Term] id: GO:0098937 name: anterograde dendritic transport namespace: biological_process def: "The directed movement of organelles or molecules along microtubules from the cell body toward the postsynapse in dendrites." [ISBN:0815316194] subset: goslim_synapse is_a: GO:0098935 ! dendritic transport intersection_of: GO:0006810 ! transport intersection_of: BFO:0000066 GO:0032839 ! occurs in dendrite cytoplasm intersection_of: RO:0002339 GO:0098794 ! has target end location postsynapse intersection_of: RO:0002341 GO:0005874 ! results in transport along microtubule relationship: BFO:0000066 GO:0032839 ! occurs in dendrite cytoplasm relationship: RO:0002339 GO:0098794 ! has target end location postsynapse [Term] id: GO:0098939 name: dendritic transport of mitochondrion namespace: biological_process def: "The directed movement of mitochondria along microtubules in nerve cell dendrites." [GOC:ai] subset: goslim_synapse is_a: GO:0047497 ! mitochondrion transport along microtubule is_a: GO:0098935 ! dendritic transport intersection_of: GO:0006810 ! transport intersection_of: BFO:0000066 GO:0032839 ! occurs in dendrite cytoplasm intersection_of: RO:0002341 GO:0005874 ! results in transport along microtubule intersection_of: RO:0004009 GO:0005739 ! has primary input mitochondrion relationship: BFO:0000066 GO:0032839 ! occurs in dendrite cytoplasm [Term] id: GO:0098940 name: anterograde trans-synaptic signaling by nitric oxide namespace: biological_process def: "Cell-cell signaling from presynapse to postynapse, across the synaptic cleft, mediated by nitric oxide." [GOC:dos] subset: goslim_synapse is_a: GO:0098916 ! anterograde trans-synaptic signaling is_a: GO:0099548 ! trans-synaptic signaling by nitric oxide intersection_of: GO:0099537 ! trans-synaptic signaling intersection_of: RO:0002231 GO:0098793 ! has start location presynapse intersection_of: RO:0002232 GO:0098794 ! has end location postsynapse intersection_of: RO:0002608 CHEBI:16480 ! process has causal agent [Term] id: GO:0098957 name: anterograde axonal transport of mitochondrion namespace: biological_process def: "The directed movement of mitochondria along microtubules in axons away from the cell body and towards the presynapse." [GOC:dos] subset: goslim_synapse synonym: "anterograde axon transport of mitochondria" EXACT [] is_a: GO:0008089 ! anterograde axonal transport is_a: GO:0019896 ! axonal transport of mitochondrion intersection_of: GO:0006810 ! transport intersection_of: BFO:0000066 GO:1904115 ! occurs in axon cytoplasm intersection_of: RO:0002339 GO:0098793 ! has target end location presynapse intersection_of: RO:0002341 GO:0005874 ! results in transport along microtubule intersection_of: RO:0004009 GO:0005739 ! has primary input mitochondrion [Term] id: GO:0098958 name: retrograde axonal transport of mitochondrion namespace: biological_process def: "The directed movement of mitochondria along microtubules in axons towards the cell body and away from the presynapse." [GOC:dos] subset: goslim_synapse synonym: "retrograde axon transport of mitochondria" EXACT [] is_a: GO:0008090 ! retrograde axonal transport is_a: GO:0019896 ! axonal transport of mitochondrion intersection_of: GO:0006810 ! transport intersection_of: BFO:0000066 GO:1904115 ! occurs in axon cytoplasm intersection_of: RO:0002338 GO:0098793 ! has target start location presynapse intersection_of: RO:0002341 GO:0005874 ! results in transport along microtubule intersection_of: RO:0004009 GO:0005739 ! has primary input mitochondrion [Term] id: GO:0098959 name: retrograde dendritic transport of mitochondrion namespace: biological_process def: "The directed movement of mitochondria along microtubules in dendrites towards the cell body and away from the postsynapse." [GOC:dos] subset: goslim_synapse synonym: "retrograde dendrite transport of mitochondria" EXACT [] is_a: GO:0098939 ! dendritic transport of mitochondrion intersection_of: GO:0006810 ! transport intersection_of: BFO:0000066 GO:0032839 ! occurs in dendrite cytoplasm intersection_of: RO:0002338 GO:0098794 ! has target start location postsynapse intersection_of: RO:0002341 GO:0005874 ! results in transport along microtubule intersection_of: RO:0004009 GO:0005739 ! has primary input mitochondrion relationship: RO:0002338 GO:0098794 ! has target start location postsynapse [Term] id: GO:0098960 name: postsynaptic neurotransmitter receptor activity namespace: molecular_function def: "Neurotransmitter receptor activity occurring in the postsynaptic membrane during synaptic transmission." [GOC:dos, GOC:signaling] synonym: "neurotransmitter receptor activity involved in chemical synaptic transmission" EXACT [] is_a: BFO:0000003 is_a: GO:0030594 ! neurotransmitter receptor activity intersection_of: GO:0030594 ! neurotransmitter receptor activity intersection_of: BFO:0000050 GO:0007268 ! part of chemical synaptic transmission relationship: BFO:0000050 GO:0099565 ! part of chemical synaptic transmission, postsynaptic relationship: BFO:0000066 GO:0045211 ! occurs in postsynaptic membrane [Term] id: GO:0098961 name: dendritic transport of ribonucleoprotein complex namespace: biological_process def: "The directed movement of a ribonucleoprotein complex along microtubules in nerve cell dendrites." [GOC:dos] subset: goslim_synapse synonym: "dendritic transport of RNP complex" EXACT [] is_a: GO:0098935 ! dendritic transport intersection_of: GO:0006810 ! transport intersection_of: BFO:0000066 GO:0032839 ! occurs in dendrite cytoplasm intersection_of: RO:0002341 GO:0005874 ! results in transport along microtubule intersection_of: RO:0004009 GO:1990904 ! has primary input ribonucleoprotein complex relationship: BFO:0000066 GO:0032839 ! occurs in dendrite cytoplasm relationship: RO:0004009 GO:1990904 ! has primary input ribonucleoprotein complex [Term] id: GO:0098967 name: exocytic insertion of neurotransmitter receptor to postsynaptic membrane namespace: biological_process def: "The exocytic fusion of neurotransmitter receptor containing vesicles with the postsynaptic membrane resulting in the integration of NT receptors, enabling them to participate in neurotransmitter reception. This process includes tethering and docking steps that prepare vesicles for fusion." [PMID:19503082] subset: goslim_synapse is_a: GO:0006887 ! exocytosis is_a: GO:0099072 ! regulation of postsynaptic membrane neurotransmitter receptor levels intersection_of: GO:0006887 ! exocytosis intersection_of: BFO:0000050 GO:0098969 ! part of neurotransmitter receptor transport to postsynaptic membrane relationship: BFO:0000050 GO:0098969 ! part of neurotransmitter receptor transport to postsynaptic membrane [Term] id: GO:0098969 name: neurotransmitter receptor transport to postsynaptic membrane namespace: biological_process def: "The directed movement of neurotransmitter receptor to the postsynaptic membrane in transport vesicles." [GOC:dos] subset: goslim_synapse is_a: GO:0097120 ! receptor localization to synapse is_a: GO:0098877 ! neurotransmitter receptor transport to plasma membrane is_a: GO:0099072 ! regulation of postsynaptic membrane neurotransmitter receptor levels is_a: GO:1903539 ! protein localization to postsynaptic membrane is_a: GO:1903540 ! establishment of protein localization to postsynaptic membrane intersection_of: GO:0015031 ! protein transport intersection_of: RO:0002339 GO:0045211 ! has target end location postsynaptic membrane intersection_of: RO:0004009 GO:0098878 ! has primary input neurotransmitter receptor complex [Term] id: GO:0098971 name: anterograde dendritic transport of neurotransmitter receptor complex namespace: biological_process def: "The directed movement of a neurotransmitter receptor complex along microtubules in nerve cell dendrites towards the postsynapse." [GOC:dos] subset: goslim_synapse is_a: GO:0097120 ! receptor localization to synapse is_a: GO:0098937 ! anterograde dendritic transport intersection_of: GO:0006810 ! transport intersection_of: BFO:0000066 GO:0032839 ! occurs in dendrite cytoplasm intersection_of: RO:0002339 GO:0098794 ! has target end location postsynapse intersection_of: RO:0002341 GO:0005874 ! results in transport along microtubule intersection_of: RO:0004009 GO:0098878 ! has primary input neurotransmitter receptor complex relationship: RO:0004009 GO:0098878 ! has primary input neurotransmitter receptor complex [Term] id: GO:0098972 name: anterograde dendritic transport of mitochondrion namespace: biological_process def: "The directed movement of mitochondria along microtubules in dendrites towards the postsynapse and away from the cell body." [GOC:dos] subset: goslim_synapse is_a: GO:0098937 ! anterograde dendritic transport is_a: GO:0098939 ! dendritic transport of mitochondrion intersection_of: GO:0006810 ! transport intersection_of: BFO:0000066 GO:0032839 ! occurs in dendrite cytoplasm intersection_of: RO:0002339 GO:0098794 ! has target end location postsynapse intersection_of: RO:0002341 GO:0005874 ! results in transport along microtubule intersection_of: RO:0004009 GO:0005739 ! has primary input mitochondrion [Term] id: GO:0098974 name: postsynaptic actin cytoskeleton organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins in the postsynaptic actin cytoskeleton." [GOC:dos] subset: goslim_synapse is_a: GO:0030036 ! actin cytoskeleton organization is_a: GO:0099188 ! postsynaptic cytoskeleton organization intersection_of: GO:0016043 ! cellular component organization intersection_of: RO:0002592 GO:0098871 ! results in organization of postsynaptic actin cytoskeleton relationship: RO:0002592 GO:0098871 ! results in organization of postsynaptic actin cytoskeleton [Term] id: GO:0098975 name: postsynapse of neuromuscular junction namespace: cellular_component def: "The postsynapse of a neuromuscular junction. In vertebrate muscles this includes the motor end-plate, consisting of postjunctional folds of the sarcolemma." [GOC:dos, Wikipedia:Neuromuscular_junction&oldid=723623502] is_a: GO:0098794 ! postsynapse intersection_of: GO:0098794 ! postsynapse intersection_of: BFO:0000050 CL:0000187 ! part of muscle cell intersection_of: BFO:0000050 GO:0031594 ! part of neuromuscular junction relationship: BFO:0000050 CL:0000187 ! part of muscle cell relationship: BFO:0000050 GO:0031594 ! part of neuromuscular junction [Term] id: GO:0098976 name: excitatory chemical synaptic transmission namespace: biological_process def: "Synaptic transmission that results in an excitatory postsynaptic potential." [GOC:dos] is_a: GO:0007268 ! chemical synaptic transmission intersection_of: GO:0007268 ! chemical synaptic transmission intersection_of: BFO:0000051 GO:0060079 ! has part excitatory postsynaptic potential relationship: BFO:0000051 GO:0060079 ! has part excitatory postsynaptic potential [Term] id: GO:0098978 name: glutamatergic synapse namespace: cellular_component def: "A synapse that uses glutamate as a neurotransmitter." [GOC:dos] subset: goslim_synapse is_a: GO:0045202 ! synapse intersection_of: GO:0045202 ! synapse intersection_of: RO:0002215 GO:0035249 ! capable of synaptic transmission, glutamatergic relationship: RO:0002215 GO:0035249 ! capable of synaptic transmission, glutamatergic [Term] id: GO:0098981 name: cholinergic synapse namespace: cellular_component def: "A synapse that uses acetylcholine as a neurotransmitter." [GOC:dos] subset: goslim_synapse is_a: GO:0045202 ! synapse intersection_of: GO:0045202 ! synapse intersection_of: RO:0002215 GO:0007271 ! capable of synaptic transmission, cholinergic relationship: RO:0002215 GO:0007271 ! capable of synaptic transmission, cholinergic [Term] id: GO:0098982 name: GABA-ergic synapse namespace: cellular_component def: "A synapse that uses GABA as a neurotransmitter. These synapses are typically inhibitory." [GOC:dos] subset: goslim_synapse is_a: GO:0045202 ! synapse intersection_of: GO:0045202 ! synapse intersection_of: RO:0002215 GO:0051932 ! capable of synaptic transmission, GABAergic relationship: RO:0002215 GO:0051932 ! capable of synaptic transmission, GABAergic [Term] id: GO:0098988 name: G protein-coupled glutamate receptor activity namespace: molecular_function def: "Combining with glutamate and transmitting a signal from one side of the membrane to the other by activating an associated G-protein, initiating a change in cell activity." [GOC:dos] synonym: "G-protein coupled glutamate receptor activity" EXACT [] is_a: GO:0004930 ! G protein-coupled receptor activity is_a: GO:0008066 ! glutamate receptor activity intersection_of: GO:0004930 ! G protein-coupled receptor activity intersection_of: RO:0004009 CHEBI:14321 ! has primary input [Term] id: GO:0098991 name: kainate selective glutamate receptor signaling pathway namespace: biological_process def: "The series of molecular signals initiated by glutamate binding to an kainate-selective glutamate receptor on the surface of the target cell, followed by the movement of ions through a channel in the receptor complex, ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:signaling, ISBN:9780071120005] subset: goslim_synapse is_a: GO:0035235 ! ionotropic glutamate receptor signaling pathway intersection_of: GO:0007165 ! signal transduction intersection_of: RO:0002224 GO:0015277 ! starts with kainate selective glutamate receptor activity relationship: RO:0002224 GO:0015277 ! starts with kainate selective glutamate receptor activity [Term] id: GO:0098992 name: neuronal dense core vesicle namespace: cellular_component def: "A dense core vesicle (granule) that is part of a neuron. These vesicles typically contain neuropeptides. They can be found in all parts of neurons, including the soma, dendrites, axonal swellings (varicosities) and synaptic terminals." [GOC:dos, ISBN:978-0-07-181001-2, Wikipedia:Neuropeptide&oldid=713905176] subset: goslim_synapse is_a: GO:0031045 ! dense core granule intersection_of: GO:0031045 ! dense core granule intersection_of: BFO:0000050 CL:0000540 ! part of neuron relationship: BFO:0000050 CL:0000540 ! part of neuron relationship: RO:0002162 NCBITaxon:6072 ! in taxon Eumetazoa [Term] id: GO:0099003 name: vesicle-mediated transport in synapse namespace: biological_process def: "Any vesicle-mediated transport that occurs in a synapse." [GOC:dos] subset: goslim_synapse is_a: BFO:0000003 is_a: GO:0016192 ! vesicle-mediated transport intersection_of: GO:0016192 ! vesicle-mediated transport intersection_of: BFO:0000066 GO:0045202 ! occurs in synapse relationship: BFO:0000066 GO:0045202 ! occurs in synapse relationship: RO:0002162 NCBITaxon:33208 ! in taxon Metazoa [Term] id: GO:0099011 name: neuronal dense core vesicle exocytosis namespace: biological_process def: "The secretion of molecules (e.g. neuropeptides, insulin-related peptides or neuromodulators such as serotonin and dopamine) contained within a neuronal dense core vesicle by fusion of the granule with the plasma membrane of a neuron in response to increased cytosolic calcium levels." [GOC:kmv, PMID:17553987, PMID:24653208] is_a: GO:1990504 ! dense core granule exocytosis intersection_of: GO:0045055 ! regulated exocytosis intersection_of: RO:0002334 GO:0007204 ! regulated by positive regulation of cytosolic calcium ion concentration intersection_of: RO:0004009 GO:0098992 ! has primary input neuronal dense core vesicle relationship: RO:0004009 GO:0098992 ! has primary input neuronal dense core vesicle [Term] id: GO:0099012 name: neuronal dense core vesicle membrane namespace: cellular_component def: "The lipid bilayer surrounding a neuronal dense core vesicle." [GOC:dos] subset: goslim_synapse is_a: GO:0032127 ! dense core granule membrane intersection_of: GO:0016020 ! membrane intersection_of: RO:0002007 GO:0098992 ! bounding layer of neuronal dense core vesicle relationship: RO:0002007 GO:0098992 ! bounding layer of neuronal dense core vesicle [Term] id: GO:0099014 name: neuronal dense core vesicle organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a neuronal dense core vesicle." [GOC:dos] is_a: GO:0061109 ! dense core granule organization intersection_of: GO:0016043 ! cellular component organization intersection_of: RO:0002592 GO:0098992 ! results in organization of neuronal dense core vesicle relationship: RO:0002592 GO:0098992 ! results in organization of neuronal dense core vesicle [Term] id: GO:0099054 name: presynapse assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form a presynapse." [GOC:bf, GOC:dos, GOC:PARL, PMID:24449494] subset: goslim_synapse synonym: "presynapse biogenesis" EXACT [GOC:mah] synonym: "presynaptic terminal assembly" EXACT [PMID:24449494] is_a: GO:0022607 ! cellular component assembly is_a: GO:0099172 ! presynapse organization intersection_of: GO:0009987 ! cellular process intersection_of: RO:0002588 GO:0098793 ! results in assembly of presynapse relationship: BFO:0000050 GO:0007416 ! part of synapse assembly relationship: RO:0002588 GO:0098793 ! results in assembly of presynapse [Term] id: GO:0099068 name: postsynapse assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form a postsynapse." [GOC:bf, GOC:dos, GOCL:PARL] synonym: "postsynapse biogenesis" EXACT [GOC:mah] is_a: GO:0022607 ! cellular component assembly is_a: GO:0099173 ! postsynapse organization intersection_of: GO:0009987 ! cellular process intersection_of: RO:0002588 GO:0098794 ! results in assembly of postsynapse relationship: BFO:0000050 GO:0007416 ! part of synapse assembly relationship: RO:0002588 GO:0098794 ! results in assembly of postsynapse [Term] id: GO:0099072 name: regulation of postsynaptic membrane neurotransmitter receptor levels namespace: biological_process def: "Any process that regulates the the local concentration of neurotransmitter receptor at the postsynaptic membrane." [GOC:dos] subset: goslim_synapse is_a: GO:0065008 ! regulation of biological quality [Term] id: GO:0099074 name: mitochondrion to lysosome vesicle-mediated transport namespace: biological_process def: "Vesicle-mediated transport of cargo from the mitochondrion to the lysosome, mediated by a mitochondrion-derived vesicle." [GOC:bc, GOC:pad, GOC:PARL-UCL, PMID:20619655] synonym: "mitochondrion to lysosome transport" EXACT [] is_a: GO:0006839 ! mitochondrial transport is_a: GO:0007041 ! lysosomal transport is_a: GO:0099075 ! mitochondrion-derived vesicle mediated transport intersection_of: GO:0016192 ! vesicle-mediated transport intersection_of: RO:0002338 GO:0005739 ! has target start location mitochondrion intersection_of: RO:0002339 GO:0005764 ! has target end location lysosome relationship: RO:0002339 GO:0005764 ! has target end location lysosome property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/26246" xsd:anyURI property_value: RO:0002161 NCBITaxon:4751 [Term] id: GO:0099075 name: mitochondrion-derived vesicle mediated transport namespace: biological_process def: "Vesicle-mediated transport of cargo from the mitochondrion by a mitochondrion-derived vesicle." [GOC:bc, GOC:pad, GOC:PARL-UCL, PMID:20619655, PMID:37131163] is_a: GO:0016192 ! vesicle-mediated transport intersection_of: GO:0016192 ! vesicle-mediated transport intersection_of: RO:0002338 GO:0005739 ! has target start location mitochondrion relationship: RO:0002338 GO:0005739 ! has target start location mitochondrion property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/26246" xsd:anyURI [Term] id: GO:0099080 name: supramolecular complex namespace: cellular_component def: "A cellular component that consists of an indeterminate number of proteins or macromolecular complexes, organized into a regular, higher-order structure such as a polymer, sheet, network or a fiber." [GOC:dos] subset: gocheck_do_not_annotate is_a: GO:0110165 ! cellular anatomical structure property_value: skos:prefLabel "supramolecular complex" xsd:string [Term] id: GO:0099081 name: supramolecular polymer namespace: cellular_component def: "A polymeric supramolecular structure." [GOC:dos] is_a: GO:0099080 ! supramolecular complex intersection_of: GO:0099080 ! supramolecular complex intersection_of: RO:0000053 PATO:0015006 ! has characteristic polymeric relationship: RO:0000053 PATO:0015006 ! has characteristic polymeric property_value: skos:prefLabel "supramolecular polymer" xsd:string [Term] id: GO:0099082 name: retrograde trans-synaptic signaling by neuropeptide namespace: biological_process def: "Cell-cell signaling from postsynapse to presynapse, across the synaptic cleft, mediated by a neuropeptide." [GOC:bf, GOC:dos, GOC:PARL, PMID:19448629] subset: goslim_synapse is_a: GO:0098917 ! retrograde trans-synaptic signaling is_a: GO:0099540 ! trans-synaptic signaling by neuropeptide intersection_of: GO:0099537 ! trans-synaptic signaling intersection_of: RO:0002231 GO:0098794 ! has start location postsynapse intersection_of: RO:0002232 GO:0098793 ! has end location presynapse intersection_of: RO:0002608 CHEBI:60466 ! process has causal agent [Term] id: GO:0099083 name: retrograde trans-synaptic signaling by neuropeptide, modulating synaptic transmission namespace: biological_process def: "Modulation of synaptic transmission by cell-cell signaling across the synaptic cleft from postsynapse to presynapse, mediated by a neuropeptide." [GOC:bf, GOC:dos, GOC:PARL, PMID:19448629] comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. subset: goslim_synapse is_a: GO:0099082 ! retrograde trans-synaptic signaling by neuropeptide is_a: GO:0099551 ! trans-synaptic signaling by neuropeptide, modulating synaptic transmission intersection_of: GO:0099537 ! trans-synaptic signaling intersection_of: RO:0002211 GO:0007268 ! regulates chemical synaptic transmission intersection_of: RO:0002231 GO:0098794 ! has start location postsynapse intersection_of: RO:0002232 GO:0098793 ! has end location presynapse intersection_of: RO:0002608 CHEBI:60466 ! process has causal agent [Term] id: GO:0099093 name: calcium export from the mitochondrion namespace: biological_process def: "A process in which a calcium ion (Ca2+) is transported out of the mitochondrial matrix, and into the cytosol." [GOC:dos, GOC:vw] synonym: "calcium ion transmembrane export from mitochondrion" EXACT [] synonym: "mitochondrial calcium ion export" BROAD [GOC:vw] synonym: "mitochondrial calcium release" EXACT [] is_a: GO:0006851 ! mitochondrial calcium ion transmembrane transport is_a: GO:0051209 ! release of sequestered calcium ion into cytosol intersection_of: GO:0006810 ! transport intersection_of: RO:0002338 GO:0005759 ! has target start location mitochondrial matrix intersection_of: RO:0002339 GO:0005829 ! has target end location cytosol intersection_of: RO:0002342 GO:0031966 ! results in transport across mitochondrial membrane intersection_of: RO:0004009 CHEBI:29108 ! has primary input relationship: RO:0002338 GO:0005759 ! has target start location mitochondrial matrix [Term] id: GO:0099094 name: ligand-gated monoatomic cation channel activity namespace: molecular_function def: "Enables the transmembrane transfer of an inorganic cation by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729] synonym: "ligand-gated cation channel activity" BROAD [] is_a: GO:0005261 ! monoatomic cation channel activity is_a: GO:0015276 ! ligand-gated monoatomic ion channel activity intersection_of: GO:0022836 ! gated channel activity intersection_of: RO:0004009 CHEBI:23906 ! has primary input intersection_of: RO:0012001 CHEBI:24431 ! has small molecule activator [Term] id: GO:0099096 name: vestibular calyx terminal namespace: cellular_component def: "The giant, cup-shaped axon terminal of a vestibular afferent neuron, serving as a post-synaptic contact to a type I hair cell." [PMID:10706428, PMID:25355208] is_a: GO:0043679 ! axon terminus [Term] id: GO:0099098 name: microtubule polymerization based movement namespace: biological_process def: "The movement of a cellular component as a result of microtubule polymerization." [GOC:cjm, ISBN:0815316194] is_a: BFO:0000003 is_a: GO:0007018 ! microtubule-based movement intersection_of: GO:0007018 ! microtubule-based movement intersection_of: BFO:0000051 GO:0046785 ! has part microtubule polymerization relationship: BFO:0000051 GO:0046785 ! has part microtubule polymerization [Term] id: GO:0099111 name: microtubule-based transport namespace: biological_process def: "A microtubule-based process that results in the transport of organelles, other microtubules, or other cellular components. Examples include motor-driven movement along microtubules and movement driven by polymerization or depolymerization of microtubules." [GOC:cjm, ISBN:0815316194] is_a: GO:0006810 ! transport intersection_of: GO:0006810 ! transport intersection_of: RO:0002608 GO:0005874 ! process has causal agent microtubule relationship: RO:0002608 GO:0005874 ! process has causal agent microtubule [Term] id: GO:0099112 name: microtubule polymerization based protein transport namespace: biological_process def: "The transport of a protein driven by polymerization of a microtubule to which it is attached." [GOC:dos, GOC:vw, PMID:11018050] is_a: GO:0006886 ! intracellular protein transport is_a: GO:0007017 ! microtubule-based process is_a: GO:0099118 ! microtubule-based protein transport intersection_of: GO:0046907 ! intracellular transport intersection_of: BFO:0000051 GO:0046785 ! has part microtubule polymerization intersection_of: RO:0002608 GO:0005874 ! process has causal agent microtubule intersection_of: RO:0004009 CHEBI:36080 ! has primary input relationship: BFO:0000051 GO:0046785 ! has part microtubule polymerization [Term] id: GO:0099118 name: microtubule-based protein transport namespace: biological_process def: "A microtubule-based process that results in the transport of proteins." [GOC:vw] is_a: GO:0015031 ! protein transport is_a: GO:0099111 ! microtubule-based transport intersection_of: GO:0006810 ! transport intersection_of: RO:0002608 GO:0005874 ! process has causal agent microtubule intersection_of: RO:0004009 PR:000000001 ! has primary input protein [Term] id: GO:0099123 name: somato-dendritic dopamine secretion namespace: biological_process def: "The regulated release of dopamine from the somatodendritic compartment (cell body or dendrites) of a neuron." [GOC:bf, GOC:PARL, PMID:21576241] synonym: "somatodendritic dopamine release" EXACT [PMID:21576241] synonym: "STD DA release" EXACT [PMID:21576241] synonym: "STD dopamine release" EXACT [PMID:21576241] is_a: GO:0014046 ! dopamine secretion is_a: GO:0051649 ! establishment of localization in cell intersection_of: GO:0014046 ! dopamine secretion intersection_of: BFO:0000066 GO:0036477 ! occurs in somatodendritic compartment relationship: BFO:0000066 GO:0036477 ! occurs in somatodendritic compartment [Term] id: GO:0099124 name: axonal dopamine secretion namespace: biological_process def: "The regulated release of dopamine from an axon." [GOC:bf, GOC:PARL, PMID:21576241] synonym: "axonal DA release" EXACT [PMID:21576241] synonym: "axonal dopamine release" EXACT [PMID:21576241] is_a: GO:0014046 ! dopamine secretion is_a: GO:0051649 ! establishment of localization in cell intersection_of: GO:0014046 ! dopamine secretion intersection_of: BFO:0000066 GO:0030424 ! occurs in axon relationship: BFO:0000066 GO:0030424 ! occurs in axon [Term] id: GO:0099140 name: presynaptic actin cytoskeleton organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins in the presynaptic actin cytoskeleton." [GOC:dos] subset: goslim_synapse is_a: GO:0030036 ! actin cytoskeleton organization is_a: GO:0099187 ! presynaptic cytoskeleton organization intersection_of: GO:0016043 ! cellular component organization intersection_of: RO:0002592 GO:0099143 ! results in organization of presynaptic actin cytoskeleton relationship: RO:0002592 GO:0099143 ! results in organization of presynaptic actin cytoskeleton creation_date: 2017-06-09T18:34:19Z [Term] id: GO:0099143 name: presynaptic actin cytoskeleton namespace: cellular_component def: "The actin cytoskeleton that is part of a presynapse." [GOC:dos] subset: goslim_synapse is_a: GO:0015629 ! actin cytoskeleton is_a: GO:0099569 ! presynaptic cytoskeleton intersection_of: GO:0015629 ! actin cytoskeleton intersection_of: BFO:0000050 GO:0098793 ! part of presynapse creation_date: 2017-06-09T18:36:19Z [Term] id: GO:0099145 name: regulation of exocytic insertion of neurotransmitter receptor to postsynaptic membrane namespace: biological_process def: "Any process that modulates the frequency, rate or extent of exocytic fusion of neurotransmitter receptor containing vesicles into the postsynaptic membrane." [GOC:dos] subset: goslim_synapse is_a: GO:0017157 ! regulation of exocytosis is_a: GO:0051223 ! regulation of protein transport is_a: GO:0065008 ! regulation of biological quality is_a: GO:1902683 ! regulation of receptor localization to synapse is_a: GO:1904375 ! regulation of protein localization to cell periphery is_a: GO:1905475 ! regulation of protein localization to membrane intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0098967 ! regulates exocytic insertion of neurotransmitter receptor to postsynaptic membrane relationship: RO:0002211 GO:0098967 ! regulates exocytic insertion of neurotransmitter receptor to postsynaptic membrane creation_date: 2017-06-09T18:49:26Z [Term] id: GO:0099156 name: cell-cell signaling via exosome namespace: biological_process def: "Cell-cell signaling in which the ligand is carried between cells by an exosome." [GOC:dos, PMID:19837038] synonym: "exosome mediated" EXACT [] is_a: GO:0007267 ! cell-cell signaling intersection_of: GO:0007267 ! cell-cell signaling intersection_of: RO:0002608 GO:0070062 ! process has causal agent extracellular exosome relationship: RO:0002608 GO:0070062 ! process has causal agent extracellular exosome creation_date: 2017-07-05T16:40:45Z [Term] id: GO:0099157 name: trans-synaptic signaling via exosome namespace: biological_process def: "Transynaptic signaling in which the ligand is carried across the synapse by an exosome." [GOC:dos, PMID:19837038] subset: goslim_synapse synonym: "exosome mediated transynaptic signalling" EXACT [] synonym: "trans-synaptic signalling via exosome" EXACT [] is_a: GO:0099156 ! cell-cell signaling via exosome is_a: GO:0099537 ! trans-synaptic signaling intersection_of: GO:0099537 ! trans-synaptic signaling intersection_of: RO:0002608 GO:0070062 ! process has causal agent extracellular exosome creation_date: 2017-07-05T16:49:44Z [Term] id: GO:0099160 name: postsynaptic intermediate filament cytoskeleton namespace: cellular_component def: "The intermediate filament cytoskeleton that is part of a postsynapse." [GOC:dos, PMID:25869803] subset: goslim_synapse is_a: GO:0045111 ! intermediate filament cytoskeleton is_a: GO:0099571 ! postsynaptic cytoskeleton intersection_of: GO:0045111 ! intermediate filament cytoskeleton intersection_of: BFO:0000050 GO:0098794 ! part of postsynapse creation_date: 2017-08-28T15:26:08Z [Term] id: GO:0099161 name: regulation of presynaptic dense core granule exocytosis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of presynaptic dense core granule exocytosis." [GOC:dos, PMID:17881523] subset: goslim_synapse synonym: "regulation of presynaptic dense core vesicle exocytosis" EXACT syngo_official_label [] is_a: GO:0099171 ! presynaptic modulation of chemical synaptic transmission is_a: GO:1903233 ! regulation of calcium ion-dependent exocytosis of neurotransmitter is_a: GO:1905413 ! regulation of dense core granule exocytosis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0099525 ! regulates presynaptic dense core vesicle exocytosis relationship: RO:0002211 GO:0099525 ! regulates presynaptic dense core vesicle exocytosis creation_date: 2017-09-10T10:59:08Z [Term] id: GO:0099163 name: synaptic signaling by nitric oxide namespace: biological_process def: "Cell-cell signaling to or from a synapse, mediated by nitric oxide." [GOC:dos, PMID:19038221] subset: goslim_synapse is_a: GO:0099536 ! synaptic signaling intersection_of: GO:0099536 ! synaptic signaling intersection_of: RO:0002608 CHEBI:16480 ! process has causal agent relationship: RO:0002608 CHEBI:16480 ! process has causal agent [Term] id: GO:0099170 name: postsynaptic modulation of chemical synaptic transmission namespace: biological_process def: "Any process, acting in the postsynapse that results in modulation of chemical synaptic transmission." [GOC:dos] subset: goslim_synapse is_a: GO:0050804 ! modulation of chemical synaptic transmission intersection_of: GO:0050804 ! modulation of chemical synaptic transmission intersection_of: BFO:0000066 GO:0098794 ! occurs in postsynapse relationship: BFO:0000066 GO:0098794 ! occurs in postsynapse creation_date: 2017-09-11T17:09:17Z [Term] id: GO:0099171 name: presynaptic modulation of chemical synaptic transmission namespace: biological_process def: "Any process, acting in the presynapse that results in modulation of chemical synaptic transmission." [GOC:dos] subset: goslim_synapse is_a: GO:0050804 ! modulation of chemical synaptic transmission intersection_of: GO:0050804 ! modulation of chemical synaptic transmission intersection_of: BFO:0000066 GO:0098793 ! occurs in presynapse relationship: BFO:0000066 GO:0098793 ! occurs in presynapse creation_date: 2017-09-11T17:09:31Z [Term] id: GO:0099172 name: presynapse organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a presynapse." [GOC:dos] subset: goslim_synapse synonym: "presynapse development" EXACT [] synonym: "presynapse morphogenesis" RELATED [GOC:BHF] synonym: "presynapse organisation" EXACT [] synonym: "presynapse organization and biogenesis" RELATED [GOC:mah] is_a: GO:0016043 ! cellular component organization intersection_of: GO:0009987 ! cellular process intersection_of: RO:0002592 GO:0098793 ! results in organization of presynapse relationship: BFO:0000050 GO:0050808 ! part of synapse organization relationship: RO:0002592 GO:0098793 ! results in organization of presynapse [Term] id: GO:0099173 name: postsynapse organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a postsynapse." [GOC:dos] subset: goslim_synapse synonym: "postsynapse development" EXACT [] synonym: "postsynapse morphogenesis" RELATED [GOC:BHF] synonym: "postsynapse organisation" EXACT [] synonym: "postsynapse organization and biogenesis" RELATED [GOC:mah] is_a: GO:0016043 ! cellular component organization intersection_of: GO:0009987 ! cellular process intersection_of: RO:0002592 GO:0098794 ! results in organization of postsynapse relationship: BFO:0000050 GO:0050808 ! part of synapse organization relationship: RO:0002592 GO:0098794 ! results in organization of postsynapse [Term] id: GO:0099174 name: regulation of presynapse organization namespace: biological_process def: "Any process that modulates the physical form of a presynapse." [GOC:ai, GOC:dph, GOC:tb] subset: goslim_synapse synonym: "regulation of presynapse organisation" EXACT [GOC:mah] synonym: "regulation of presynapse organization and biogenesis" RELATED [GOC:mah] synonym: "regulation of presynapse structure" EXACT [] is_a: GO:0050807 ! regulation of synapse organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0099172 ! regulates presynapse organization relationship: RO:0002211 GO:0099172 ! regulates presynapse organization [Term] id: GO:0099175 name: regulation of postsynapse organization namespace: biological_process def: "Any process that modulates the physical form of a postsynapse." [GOC:ai, GOC:dph, GOC:tb] subset: goslim_synapse synonym: "regulation of postsynapse organisation" EXACT [GOC:mah] synonym: "regulation of postsynapse organization and biogenesis" RELATED [GOC:mah] synonym: "regulation of postsynapse structure" EXACT [] is_a: GO:0050807 ! regulation of synapse organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0099173 ! regulates postsynapse organization relationship: RO:0002211 GO:0099173 ! regulates postsynapse organization [Term] id: GO:0099177 name: regulation of trans-synaptic signaling namespace: biological_process def: "Any process that modulates the frequency, rate or extent of trans-synaptic signaling." [GOC:dos] is_a: GO:0010646 ! regulation of cell communication is_a: GO:0023051 ! regulation of signaling intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0099537 ! regulates trans-synaptic signaling relationship: RO:0002211 GO:0099537 ! regulates trans-synaptic signaling [Term] id: GO:0099182 name: presynaptic intermediate filament cytoskeleton namespace: cellular_component def: "The intermediate filament cytoskeleton that is part of a presynapse." [GOC:dos] subset: goslim_synapse is_a: GO:0045111 ! intermediate filament cytoskeleton is_a: GO:0099569 ! presynaptic cytoskeleton intersection_of: GO:0045111 ! intermediate filament cytoskeleton intersection_of: BFO:0000050 GO:0098793 ! part of presynapse creation_date: 2017-12-01T18:10:21Z [Term] id: GO:0099185 name: postsynaptic intermediate filament cytoskeleton organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprised of intermediate filament and their associated proteins in the postsynaptic cytoskeleton." [GOC:dos] subset: goslim_synapse is_a: GO:0045104 ! intermediate filament cytoskeleton organization is_a: GO:0099188 ! postsynaptic cytoskeleton organization intersection_of: GO:0016043 ! cellular component organization intersection_of: RO:0002592 GO:0099160 ! results in organization of postsynaptic intermediate filament cytoskeleton relationship: RO:0002592 GO:0099160 ! results in organization of postsynaptic intermediate filament cytoskeleton creation_date: 2017-12-20T13:47:30Z [Term] id: GO:0099187 name: presynaptic cytoskeleton organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures and their associated proteins in the presynaptic cytoskeleton." [GOC:dos] is_a: GO:0007010 ! cytoskeleton organization intersection_of: GO:0009987 ! cellular process intersection_of: RO:0002592 GO:0099569 ! results in organization of presynaptic cytoskeleton relationship: BFO:0000050 GO:0099172 ! part of presynapse organization relationship: RO:0002592 GO:0099569 ! results in organization of presynaptic cytoskeleton creation_date: 2017-12-20T15:05:34Z [Term] id: GO:0099188 name: postsynaptic cytoskeleton organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising cytoskeletal filaments and their associated proteins in the postsynaptic cytoskeleton." [GOC:dos] subset: goslim_synapse is_a: GO:0007010 ! cytoskeleton organization intersection_of: GO:0016043 ! cellular component organization intersection_of: RO:0002592 GO:0099571 ! results in organization of postsynaptic cytoskeleton relationship: BFO:0000050 GO:0099173 ! part of postsynapse organization relationship: RO:0002592 GO:0099571 ! results in organization of postsynaptic cytoskeleton creation_date: 2017-12-20T15:06:57Z [Term] id: GO:0099500 name: vesicle fusion to plasma membrane namespace: biological_process def: "Fusion of the membrane of a vesicle with the plasma membrane, thereby releasing its contents into the extracellular space." [GOC:aruk, GOC:bc, ISBN:0071120009, PMID:18618940] is_a: GO:0006906 ! vesicle fusion is_a: GO:0140029 ! exocytic process intersection_of: GO:0061025 ! membrane fusion intersection_of: BFO:0000050 GO:0006887 ! part of exocytosis intersection_of: RO:0012008 GO:0012506 ! results in fusion of vesicle membrane intersection_of: RO:0012008 GO:0098590 ! results in fusion of plasma membrane region relationship: RO:0012008 GO:0098590 ! results in fusion of plasma membrane region [Term] id: GO:0099501 name: exocytic vesicle membrane namespace: cellular_component def: "The lipid bilayer surrounding an exocytic vesicle." [GOC:dos] synonym: "secretory vesicle membrane" BROAD [] is_a: GO:0030658 ! transport vesicle membrane intersection_of: GO:0016020 ! membrane intersection_of: RO:0002007 GO:0070382 ! bounding layer of exocytic vesicle relationship: RO:0002007 GO:0070382 ! bounding layer of exocytic vesicle [Term] id: GO:0099503 name: secretory vesicle namespace: cellular_component def: "A cytoplasmic, membrane bound vesicle that is capable of fusing to the plasma membrane to release its contents into the extracellular space." [GOC:dos] subset: goslim_drosophila is_a: GO:0031410 ! cytoplasmic vesicle intersection_of: GO:0031982 ! vesicle intersection_of: RO:0002215 GO:0099500 ! capable of vesicle fusion to plasma membrane relationship: RO:0002215 GO:0099500 ! capable of vesicle fusion to plasma membrane [Term] id: GO:0099504 name: synaptic vesicle cycle namespace: biological_process def: "A biological process in which synaptic vesicles are loaded with neurotransmitters, move to the active zone, exocytose and are then recycled via endocytosis, ultimately leading to reloading with neurotransmitters." [GOC:aruk, GOC:bc, PMID:15217342] subset: goslim_synapse is_a: GO:0051649 ! establishment of localization in cell is_a: GO:0099003 ! vesicle-mediated transport in synapse relationship: BFO:0000066 GO:0098793 ! occurs in presynapse [Term] id: GO:0099512 name: supramolecular fiber namespace: cellular_component def: "A polymer consisting of an indefinite number of protein or protein complex subunits that have polymerised to form a fiber-shaped structure." [GOC:dos] synonym: "fibril" RELATED [] is_a: GO:0099081 ! supramolecular polymer intersection_of: GO:0099080 ! supramolecular complex intersection_of: RO:0000053 PATO:0002309 ! has characteristic fiber shaped intersection_of: RO:0000053 PATO:0015006 ! has characteristic polymeric relationship: RO:0000053 PATO:0002309 ! has characteristic fiber shaped property_value: skos:prefLabel "supramolecular fiber" xsd:string [Term] id: GO:0099513 name: polymeric cytoskeletal fiber namespace: cellular_component def: "A component of the cytoskeleton consisting of a homo or heteropolymeric fiber constructed from an indeterminate number of protein subunits." [GOC:dos] is_a: GO:0099512 ! supramolecular fiber intersection_of: GO:0099512 ! supramolecular fiber intersection_of: BFO:0000050 GO:0005856 ! part of cytoskeleton intersection_of: RO:0000053 PATO:0015006 ! has characteristic polymeric relationship: BFO:0000050 GO:0005856 ! part of cytoskeleton [Term] id: GO:0099515 name: actin filament-based transport namespace: biological_process def: "The transport of organelles or other particles from one location in the cell to another along actin filaments." [GOC:dos, GOC:dph, GOC:mah, GOC:tb] is_a: GO:0030705 ! cytoskeleton-dependent intracellular transport intersection_of: GO:0046907 ! intracellular transport intersection_of: RO:0002341 GO:0005884 ! results in transport along actin filament relationship: RO:0002341 GO:0005884 ! results in transport along actin filament creation_date: 2009-05-27T10:56:08Z [Term] id: GO:0099518 name: vesicle cytoskeletal trafficking namespace: biological_process def: "The directed movement of a vesicle along a cytoskeletal fiber such as a microtubule or and actin filament, mediated by motor proteins." [GOC:ecd, GOC:rl] synonym: "cytoskeletal fiber-based vesicle localization" EXACT [GOC:rl] synonym: "vesicle cytoskeletal transport" EXACT [] is_a: GO:0030705 ! cytoskeleton-dependent intracellular transport is_a: GO:0051650 ! establishment of vesicle localization intersection_of: GO:0046907 ! intracellular transport intersection_of: RO:0002341 GO:0099513 ! results in transport along polymeric cytoskeletal fiber intersection_of: RO:0004009 GO:0031982 ! has primary input vesicle [Term] id: GO:0099519 name: dense core granule cytoskeletal transport namespace: biological_process def: "The directed movement of dense core granules along cytoskeletal fibers, such as microtubules or actin filaments." [GOC:kmv, PMID:23358451] synonym: "dense core vesicle cytoskeletal trafficking" EXACT [] is_a: GO:0099518 ! vesicle cytoskeletal trafficking is_a: GO:1901950 ! dense core granule transport intersection_of: GO:0046907 ! intracellular transport intersection_of: BFO:0000066 GO:0030424 ! occurs in axon intersection_of: RO:0002341 GO:0099513 ! results in transport along polymeric cytoskeletal fiber intersection_of: RO:0004009 GO:0031045 ! has primary input dense core granule relationship: BFO:0000066 GO:0030424 ! occurs in axon [Term] id: GO:0099522 name: cytosolic region namespace: cellular_component def: "Any (proper) part of the cytosol of a single cell of sufficient size to still be considered cytosol." [GOC:dos] subset: gocheck_do_not_annotate synonym: "region of cytosol" EXACT [] is_a: GO:0005829 ! cytosol intersection_of: GO:0005829 ! cytosol intersection_of: BFO:0000050 GO:0005829 ! part of cytosol relationship: BFO:0000050 GO:0005829 ! part of cytosol [Term] id: GO:0099523 name: presynaptic cytosol namespace: cellular_component def: "The region of the cytosol consisting of all cytosol that is part of the presynapse." [GOC:dos] subset: goslim_synapse is_a: GO:0099522 ! cytosolic region intersection_of: GO:0005829 ! cytosol intersection_of: BFO:0000050 GO:0005829 ! part of cytosol intersection_of: BFO:0000050 GO:0098793 ! part of presynapse relationship: BFO:0000050 GO:0098793 ! part of presynapse [Term] id: GO:0099524 name: postsynaptic cytosol namespace: cellular_component def: "The region of the cytosol consisting of all cytosol that is part of the postsynapse." [GOC:dos] subset: goslim_synapse is_a: GO:0099522 ! cytosolic region intersection_of: GO:0005829 ! cytosol intersection_of: BFO:0000050 GO:0005829 ! part of cytosol intersection_of: BFO:0000050 GO:0098794 ! part of postsynapse relationship: BFO:0000050 GO:0098794 ! part of postsynapse [Term] id: GO:0099525 name: presynaptic dense core vesicle exocytosis namespace: biological_process def: "The secretion of molecules (e.g. neuropeptides and neuromodulators such as serotonin and dopamine) contained within a membrane-bounced dense in response to increased presynaptic cytosolic calcium levels." [PMID:17553987, PMID:24653208] subset: goslim_synapse is_a: GO:0048791 ! calcium ion-regulated exocytosis of neurotransmitter is_a: GO:0099011 ! neuronal dense core vesicle exocytosis intersection_of: GO:0045055 ! regulated exocytosis intersection_of: BFO:0000066 GO:0098793 ! occurs in presynapse intersection_of: RO:0002334 GO:0007204 ! regulated by positive regulation of cytosolic calcium ion concentration intersection_of: RO:0004009 GO:0098992 ! has primary input neuronal dense core vesicle [Term] id: GO:0099528 name: G protein-coupled neurotransmitter receptor activity namespace: molecular_function def: "Combining with a neurotransmitter and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, GOC:fj, GOC:mah] synonym: "G-protein coupled neurotransmitter receptor activity" EXACT [] is_a: GO:0004930 ! G protein-coupled receptor activity is_a: GO:0030594 ! neurotransmitter receptor activity [Term] id: GO:0099529 name: neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential namespace: molecular_function def: "Neurotransmitter receptor activity occurring in the postsynaptic membrane that is involved in regulating postsynaptic membrane potential, either directly (ionotropic receptors) or indirectly (e.g. via GPCR activation of an ion channel)." [GOC:dos] subset: goslim_synapse is_a: GO:0098960 ! postsynaptic neurotransmitter receptor activity intersection_of: GO:0030594 ! neurotransmitter receptor activity intersection_of: BFO:0000050 GO:0060078 ! part of regulation of postsynaptic membrane potential relationship: BFO:0000050 GO:0060078 ! part of regulation of postsynaptic membrane potential [Term] id: GO:0099530 name: G protein-coupled receptor activity involved in regulation of postsynaptic membrane potential namespace: molecular_function def: "A G protein-coupled receptor activity occurring in the postsynaptic membrane that is part of a GPCR signaling pathway that positively regulates ion channel activity in the postsynaptic membrane." [GOC:dos] subset: goslim_synapse synonym: "G-protein coupled receptor activity involved in regulation of postsynaptic membrane potential" EXACT [] is_a: GO:0004930 ! G protein-coupled receptor activity intersection_of: GO:0004930 ! G protein-coupled receptor activity intersection_of: BFO:0000050 GO:0060078 ! part of regulation of postsynaptic membrane potential relationship: BFO:0000050 GO:0060078 ! part of regulation of postsynaptic membrane potential relationship: BFO:0000066 GO:0045211 ! occurs in postsynaptic membrane [Term] id: GO:0099531 name: presynaptic process involved in chemical synaptic transmission namespace: biological_process def: "The pathway leading to secretion of a neurotransmitter from the presynapse as part of synaptic transmission." [GOC:dos] subset: gocheck_obsoletion_candidate subset: goslim_synapse is_a: GO:0050877 ! nervous system process intersection_of: GO:0050877 ! nervous system process intersection_of: BFO:0000050 GO:0007268 ! part of chemical synaptic transmission intersection_of: BFO:0000066 GO:0098793 ! occurs in presynapse relationship: BFO:0000050 GO:0007268 ! part of chemical synaptic transmission relationship: BFO:0000066 GO:0098793 ! occurs in presynapse [Term] id: GO:0099533 name: positive regulation of presynaptic cytosolic calcium concentration namespace: biological_process def: "Any process that increases the concentration of calcium ions in the presynaptic cytosol." [GOC:dos] subset: goslim_synapse is_a: BFO:0000003 is_a: GO:0007204 ! positive regulation of cytosolic calcium ion concentration intersection_of: GO:0007204 ! positive regulation of cytosolic calcium ion concentration intersection_of: BFO:0000066 GO:0098793 ! occurs in presynapse relationship: BFO:0000066 GO:0098793 ! occurs in presynapse [Term] id: GO:0099536 name: synaptic signaling namespace: biological_process def: "Cell-cell signaling to, from or within a synapse." [GOC:dos] subset: goslim_drosophila subset: goslim_synapse is_a: GO:0007267 ! cell-cell signaling intersection_of: GO:0007267 ! cell-cell signaling intersection_of: BFO:0000066 GO:0045202 ! occurs in synapse relationship: BFO:0000066 GO:0045202 ! occurs in synapse relationship: RO:0002162 NCBITaxon:33208 ! in taxon Metazoa [Term] id: GO:0099537 name: trans-synaptic signaling namespace: biological_process def: "Cell-cell signaling in either direction across the synaptic cleft." [GOC:dos] subset: goslim_synapse is_a: GO:0099536 ! synaptic signaling [Term] id: GO:0099538 name: synaptic signaling via neuropeptide namespace: biological_process def: "Cell-cell signaling to or from a synapse, mediated by a peptide." [GOC:dos] subset: goslim_synapse is_a: GO:0099536 ! synaptic signaling intersection_of: GO:0099536 ! synaptic signaling intersection_of: RO:0002608 CHEBI:60466 ! process has causal agent relationship: RO:0002608 CHEBI:60466 ! process has causal agent [Term] id: GO:0099539 name: neuropeptide secretion from presynapse namespace: biological_process def: "The secretion of neuropeptides contained within a dense core vesicle by fusion of the granule with the presynaptic membrane, stimulated by a rise in cytosolic calcium ion concentration." [PMID:17553987, PMID:24653208] subset: goslim_synapse synonym: "neuropeptide secretion from presynapse via dense core granule exocytosis" EXACT [] is_a: GO:0002790 ! peptide secretion is_a: GO:0099525 ! presynaptic dense core vesicle exocytosis intersection_of: GO:0045055 ! regulated exocytosis intersection_of: BFO:0000066 GO:0098793 ! occurs in presynapse intersection_of: RO:0002334 GO:0007204 ! regulated by positive regulation of cytosolic calcium ion concentration intersection_of: RO:0004009 CHEBI:60466 ! has primary input intersection_of: RO:0004009 GO:0098992 ! has primary input neuronal dense core vesicle relationship: BFO:0000050 GO:0099538 ! part of synaptic signaling via neuropeptide [Term] id: GO:0099540 name: trans-synaptic signaling by neuropeptide namespace: biological_process def: "Cell-cell signaling between presynapse and postsynapse mediated by a peptide ligand crossing the synaptic cleft." [GOC:dos] subset: goslim_synapse is_a: GO:0099537 ! trans-synaptic signaling is_a: GO:0099538 ! synaptic signaling via neuropeptide intersection_of: GO:0099537 ! trans-synaptic signaling intersection_of: RO:0002608 CHEBI:60466 ! process has causal agent [Term] id: GO:0099541 name: trans-synaptic signaling by lipid namespace: biological_process def: "Cell-cell signaling from post to pre-synapse, across the synaptic cleft, mediated by a lipid." [GOC:dos] subset: goslim_synapse is_a: GO:0099537 ! trans-synaptic signaling intersection_of: GO:0099537 ! trans-synaptic signaling intersection_of: RO:0002608 CHEBI:18059 ! process has causal agent relationship: RO:0002608 CHEBI:18059 ! process has causal agent [Term] id: GO:0099543 name: trans-synaptic signaling by soluble gas namespace: biological_process def: "Cell-cell signaling between presynapse and postsynapse mediated by a soluble gas ligand crossing the synaptic cleft." [GOC:dos] subset: goslim_synapse is_a: GO:0099537 ! trans-synaptic signaling [Term] id: GO:0099546 name: protein catabolic process, modulating synaptic transmission namespace: biological_process def: "Any protein degradation process, occurring at a presynapse, that regulates synaptic transmission." [GOC:dos, PMID:23083742] comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. subset: goslim_synapse is_a: GO:0140246 ! protein catabolic process at synapse intersection_of: GO:0009056 ! catabolic process intersection_of: BFO:0000066 GO:0045202 ! occurs in synapse intersection_of: RO:0002211 GO:0007268 ! regulates chemical synaptic transmission intersection_of: RO:0004009 CHEBI:36080 ! has primary input relationship: RO:0002211 GO:0007268 ! regulates chemical synaptic transmission [Term] id: GO:0099547 name: regulation of translation at synapse, modulating synaptic transmission namespace: biological_process def: "Any process that modulates synaptic transmission by regulating translation occurring at the synapse." [GOC:dos] comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. subset: goslim_synapse is_a: GO:0050804 ! modulation of chemical synaptic transmission is_a: GO:0140243 ! regulation of translation at synapse intersection_of: GO:0065007 ! biological regulation intersection_of: BFO:0000066 GO:0045202 ! occurs in synapse intersection_of: RO:0002211 GO:0006412 ! regulates translation intersection_of: RO:0002211 GO:0007268 ! regulates chemical synaptic transmission [Term] id: GO:0099548 name: trans-synaptic signaling by nitric oxide namespace: biological_process def: "Cell-cell signaling between presynapse and postsynapse mediated by nitric oxide." [GOC:dos] subset: goslim_synapse is_a: GO:0099163 ! synaptic signaling by nitric oxide is_a: GO:0099543 ! trans-synaptic signaling by soluble gas intersection_of: GO:0099537 ! trans-synaptic signaling intersection_of: RO:0002608 CHEBI:16480 ! process has causal agent [Term] id: GO:0099550 name: trans-synaptic signaling, modulating synaptic transmission namespace: biological_process def: "Cell-cell signaling between presynapse and postsynapse, across the synaptic cleft, that modulates the synaptic transmission properties of the synapse." [GOC:dos] comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. subset: goslim_synapse is_a: GO:0050804 ! modulation of chemical synaptic transmission is_a: GO:0099537 ! trans-synaptic signaling intersection_of: GO:0099537 ! trans-synaptic signaling intersection_of: RO:0002211 GO:0007268 ! regulates chemical synaptic transmission [Term] id: GO:0099551 name: trans-synaptic signaling by neuropeptide, modulating synaptic transmission namespace: biological_process def: "Cell-cell signaling between presynapse and postsynapse, via the vesicular release and reception of neuropeptide molecules, that modulates the synaptic transmission properties of the synapse." [GOC:dos] comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. subset: goslim_synapse is_a: GO:0099540 ! trans-synaptic signaling by neuropeptide is_a: GO:0099550 ! trans-synaptic signaling, modulating synaptic transmission intersection_of: GO:0099537 ! trans-synaptic signaling intersection_of: RO:0002211 GO:0007268 ! regulates chemical synaptic transmission intersection_of: RO:0002608 CHEBI:60466 ! process has causal agent [Term] id: GO:0099552 name: trans-synaptic signaling by lipid, modulating synaptic transmission namespace: biological_process def: "Cell-cell signaling between presynapse and postsynapse, via the release and reception of lipid molecules, that modulates the synaptic transmission properties of the synapse." [GOC:dos, PMID:21531987] comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. subset: goslim_synapse is_a: GO:0099541 ! trans-synaptic signaling by lipid is_a: GO:0099550 ! trans-synaptic signaling, modulating synaptic transmission intersection_of: GO:0099537 ! trans-synaptic signaling intersection_of: RO:0002211 GO:0007268 ! regulates chemical synaptic transmission intersection_of: RO:0002608 CHEBI:18059 ! process has causal agent [Term] id: GO:0099554 name: trans-synaptic signaling by soluble gas, modulating synaptic transmission namespace: biological_process def: "Cell-cell signaling between presynapse and postsynapse, via the release and reception of gaseous molecules, that modulates the synaptic transmission properties of the synapse." [GOC:dos] comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. subset: goslim_synapse is_a: GO:0099543 ! trans-synaptic signaling by soluble gas is_a: GO:0099550 ! trans-synaptic signaling, modulating synaptic transmission [Term] id: GO:0099555 name: trans-synaptic signaling by nitric oxide, modulating synaptic transmission namespace: biological_process def: "Cell-cell signaling between presynapse and postsynapse, via the release and reception of nitric oxide molecules, that modulates the synaptic transmission properties of the synapse." [GOC:dos] comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. subset: goslim_synapse is_a: GO:0099548 ! trans-synaptic signaling by nitric oxide is_a: GO:0099554 ! trans-synaptic signaling by soluble gas, modulating synaptic transmission intersection_of: GO:0099537 ! trans-synaptic signaling intersection_of: RO:0002211 GO:0007268 ! regulates chemical synaptic transmission intersection_of: RO:0002608 CHEBI:16480 ! process has causal agent [Term] id: GO:0099565 name: chemical synaptic transmission, postsynaptic namespace: biological_process def: "The part of synaptic transmission occurring in the post-synapse: a signal transduction pathway consisting of neurotransmitter receptor activation and its effects on postsynaptic membrane potential and the ionic composition of the postsynaptic cytosol." [GOC:dos] subset: goslim_synapse synonym: "postsynaptic process involved in chemical synaptic transmission" EXACT syngo_official_label [] is_a: GO:0007166 ! cell surface receptor signaling pathway is_a: GO:0050877 ! nervous system process intersection_of: GO:0007166 ! cell surface receptor signaling pathway intersection_of: BFO:0000050 GO:0007268 ! part of chemical synaptic transmission intersection_of: BFO:0000066 GO:0098794 ! occurs in postsynapse relationship: BFO:0000050 GO:0007268 ! part of chemical synaptic transmission relationship: BFO:0000066 GO:0098794 ! occurs in postsynapse [Term] id: GO:0099568 name: cytoplasmic region namespace: cellular_component def: "Any (proper) part of the cytoplasm of a single cell of sufficient size to still be considered cytoplasm." [GOC:dos] subset: gocheck_do_not_annotate is_a: GO:0005737 ! cytoplasm intersection_of: GO:0005737 ! cytoplasm intersection_of: BFO:0000050 GO:0005737 ! part of cytoplasm relationship: BFO:0000050 GO:0005737 ! part of cytoplasm [Term] id: GO:0099569 name: presynaptic cytoskeleton namespace: cellular_component def: "The portion of the cytoskeleton contained within the presynapse." [GOC:dos] subset: goslim_synapse is_a: GO:0005856 ! cytoskeleton intersection_of: GO:0005856 ! cytoskeleton intersection_of: BFO:0000050 GO:0098793 ! part of presynapse relationship: BFO:0000050 GO:0098793 ! part of presynapse [Term] id: GO:0099571 name: postsynaptic cytoskeleton namespace: cellular_component def: "The portion of the cytoskeleton contained within the postsynapse." [GOC:dos, PMID:19889835] subset: goslim_synapse is_a: GO:0005856 ! cytoskeleton intersection_of: GO:0005856 ! cytoskeleton intersection_of: BFO:0000050 GO:0098794 ! part of postsynapse relationship: BFO:0000050 GO:0098794 ! part of postsynapse [Term] id: GO:0099574 name: regulation of protein catabolic process at synapse, modulating synaptic transmission namespace: biological_process def: "Any process that modulates synaptic transmission by regulating protein degradation at the synapse." [GOC:dos] comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. subset: goslim_synapse is_a: GO:0050804 ! modulation of chemical synaptic transmission is_a: GO:0140250 ! regulation protein catabolic process at synapse intersection_of: GO:0065007 ! biological regulation intersection_of: BFO:0000066 GO:0045202 ! occurs in synapse intersection_of: RO:0002211 GO:0007268 ! regulates chemical synaptic transmission intersection_of: RO:0002211 GO:0009056 ! regulates catabolic process intersection_of: RO:0004009 CHEBI:36080 ! has primary input [Term] id: GO:0099575 name: regulation of protein catabolic process at presynapse, modulating synaptic transmission namespace: biological_process def: "Any process that modulates synaptic transmission by regulating a catabolic process occurring at a presynapse." [GOC:dos] comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. subset: goslim_synapse is_a: GO:0042176 ! regulation of protein catabolic process is_a: GO:0099171 ! presynaptic modulation of chemical synaptic transmission intersection_of: GO:0042176 ! regulation of protein catabolic process intersection_of: BFO:0000066 GO:0098793 ! occurs in presynapse intersection_of: RO:0002211 GO:0007268 ! regulates chemical synaptic transmission [Term] id: GO:0099576 name: regulation of protein catabolic process at postsynapse, modulating synaptic transmission namespace: biological_process def: "Any process that modulates synaptic transmission by regulating a catabolic process occurring at a postsynapse." [GOC:dos] comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. subset: goslim_synapse is_a: GO:0042176 ! regulation of protein catabolic process is_a: GO:0099170 ! postsynaptic modulation of chemical synaptic transmission intersection_of: GO:0042176 ! regulation of protein catabolic process intersection_of: BFO:0000066 GO:0098794 ! occurs in postsynapse intersection_of: RO:0002211 GO:0007268 ! regulates chemical synaptic transmission [Term] id: GO:0099577 name: regulation of translation at presynapse, modulating synaptic transmission namespace: biological_process def: "Any process that modulates synaptic transmission by regulating translation occurring at the presynapse." [GOC:dos] comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. subset: goslim_synapse is_a: GO:0099171 ! presynaptic modulation of chemical synaptic transmission is_a: GO:0099547 ! regulation of translation at synapse, modulating synaptic transmission is_a: GO:0140244 ! regulation of translation at presynapse intersection_of: GO:0065007 ! biological regulation intersection_of: BFO:0000066 GO:0098793 ! occurs in presynapse intersection_of: RO:0002211 GO:0006412 ! regulates translation intersection_of: RO:0002211 GO:0007268 ! regulates chemical synaptic transmission [Term] id: GO:0099578 name: regulation of translation at postsynapse, modulating synaptic transmission namespace: biological_process def: "Any process that modulates synaptic transmission by regulating translation occurring at the postsynapse." [GOC:dos] comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. subset: goslim_synapse is_a: GO:0099170 ! postsynaptic modulation of chemical synaptic transmission is_a: GO:0099547 ! regulation of translation at synapse, modulating synaptic transmission is_a: GO:0140245 ! regulation of translation at postsynapse intersection_of: GO:0065007 ! biological regulation intersection_of: BFO:0000066 GO:0098794 ! occurs in postsynapse intersection_of: RO:0002211 GO:0006412 ! regulates translation intersection_of: RO:0002211 GO:0007268 ! regulates chemical synaptic transmission [Term] id: GO:0099579 name: G protein-coupled neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential namespace: molecular_function def: "A G protein-coupled neurotransmitter receptor activity, occurring in the postsynaptic membrane, involved in regulation of postsynaptic membrane potential." [GOC:dos] subset: goslim_synapse synonym: "G-protein coupled neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential" EXACT [] is_a: GO:0099528 ! G protein-coupled neurotransmitter receptor activity is_a: GO:0099529 ! neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential is_a: GO:0099530 ! G protein-coupled receptor activity involved in regulation of postsynaptic membrane potential intersection_of: GO:0099528 ! G protein-coupled neurotransmitter receptor activity intersection_of: BFO:0000050 GO:0060078 ! part of regulation of postsynaptic membrane potential [Term] id: GO:0099585 name: release of sequestered calcium ion into presynaptic cytosol namespace: biological_process def: "The process in which calcium ions sequestered in the endoplasmic reticulum, Golgi apparatus or mitochondria are released into the presynaptic cytosol." [GOC:dos] subset: goslim_synapse is_a: GO:0051209 ! release of sequestered calcium ion into cytosol is_a: GO:0051649 ! establishment of localization in cell intersection_of: GO:0006810 ! transport intersection_of: RO:0002338 GO:0043231 ! has target start location intracellular membrane-bounded organelle intersection_of: RO:0002339 GO:0099523 ! has target end location presynaptic cytosol intersection_of: RO:0002342 GO:0031090 ! results in transport across organelle membrane intersection_of: RO:0004009 CHEBI:29108 ! has primary input relationship: BFO:0000066 GO:0098793 ! occurs in presynapse relationship: RO:0002339 GO:0099523 ! has target end location presynaptic cytosol relationship: RO:0002342 GO:0031090 ! results in transport across organelle membrane [Term] id: GO:0099586 name: release of sequestered calcium ion into postsynaptic cytosol namespace: biological_process def: "The process in which calcium ions sequestered in the endoplasmic reticulum, Golgi apparatus or mitochondria are released into the postsynaptic cytosol." [GOC:dos] subset: goslim_synapse is_a: GO:0051209 ! release of sequestered calcium ion into cytosol is_a: GO:0051649 ! establishment of localization in cell intersection_of: GO:0006810 ! transport intersection_of: RO:0002338 GO:0043231 ! has target start location intracellular membrane-bounded organelle intersection_of: RO:0002339 GO:0099524 ! has target end location postsynaptic cytosol intersection_of: RO:0002342 GO:0031090 ! results in transport across organelle membrane intersection_of: RO:0004009 CHEBI:29108 ! has primary input relationship: BFO:0000066 GO:0098794 ! occurs in postsynapse relationship: RO:0002339 GO:0099524 ! has target end location postsynaptic cytosol relationship: RO:0002342 GO:0031090 ! results in transport across organelle membrane [Term] id: GO:0099587 name: inorganic ion import across plasma membrane namespace: biological_process def: "The directed movement of inorganic ions from outside of a cell, across the plasma membrane and into the cytosol." [GOC:dos] synonym: "inorganic ion import into cell" EXACT [] is_a: GO:0098739 ! import across plasma membrane intersection_of: GO:0006810 ! transport intersection_of: RO:0002338 GO:0005576 ! has target start location extracellular region intersection_of: RO:0002339 GO:0005829 ! has target end location cytosol intersection_of: RO:0002342 GO:0005886 ! results in transport across plasma membrane intersection_of: RO:0004009 CHEBI:36914 ! has primary input relationship: RO:0004009 CHEBI:36914 ! has primary input [Term] id: GO:0099588 name: positive regulation of postsynaptic cytosolic calcium concentration namespace: biological_process def: "Any process that increases the concentration of calcium ions in the postsynaptic cytosol." [GOC:dos] subset: goslim_synapse is_a: BFO:0000003 is_a: GO:0007204 ! positive regulation of cytosolic calcium ion concentration intersection_of: GO:0007204 ! positive regulation of cytosolic calcium ion concentration intersection_of: BFO:0000066 GO:0098794 ! occurs in postsynapse relationship: BFO:0000066 GO:0098794 ! occurs in postsynapse [Term] id: GO:0099589 name: serotonin receptor activity namespace: molecular_function def: "Combining with the biogenic amine serotonin and transmitting a signal across a membrane by activating some effector activity. Serotonin (5-hydroxytryptamine) is a neurotransmitter and hormone found in vertebrates and invertebrates." [GOC:dos] is_a: BFO:0000003 is_a: GO:0004888 ! transmembrane signaling receptor activity intersection_of: GO:0004888 ! transmembrane signaling receptor activity intersection_of: RO:0012001 CHEBI:350546 ! has small molecule activator relationship: RO:0012001 CHEBI:350546 ! has small molecule activator [Term] id: GO:0099601 name: regulation of neurotransmitter receptor activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of neurotransmitter receptor activity. Modulation may be via an effect on ligand affinity, or effector function such as ion selectivity or pore opening/closing in ionotropic receptors." [GOC:dos] subset: gocheck_obsoletion_candidate subset: goslim_synapse is_a: GO:0010469 ! regulation of signaling receptor activity intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0030594 ! regulates neurotransmitter receptor activity relationship: RO:0002211 GO:0030594 ! regulates neurotransmitter receptor activity [Term] id: GO:0099604 name: ligand-gated calcium channel activity namespace: molecular_function def: "Enables the transmembrane transfer of a calcium ions by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts." [GOC:dos] xref: Reactome:R-HSA-1168376 "STIM1 oligomerizes" xref: Reactome:R-HSA-169680 "IP3 binds to the IP3 receptor, opening the endoplasmic reticulum Ca2+ channel" xref: Reactome:R-HSA-169683 "IP3R:I(1,4,5)P3 tetramer transports Ca2+ from ER lumen to cytosol" xref: Reactome:R-HSA-4420052 "Decreasing cGMP concentration promotes intracellular Ca2+ release in response to WNT" is_a: GO:0005262 ! calcium channel activity is_a: GO:0099094 ! ligand-gated monoatomic cation channel activity intersection_of: GO:0022836 ! gated channel activity intersection_of: RO:0004009 CHEBI:29108 ! has primary input intersection_of: RO:0012001 CHEBI:24431 ! has small molecule activator relationship: BFO:0000050 GO:0019722 ! part of calcium-mediated signaling [Term] id: GO:0099612 name: protein localization to axon namespace: biological_process def: "A process in which a protein is transported to or maintained in a location within an axon." [GOC:dos, PMID:26157139] is_a: GO:0008104 ! intracellular protein localization intersection_of: GO:0008104 ! intracellular protein localization intersection_of: RO:0002339 GO:0030424 ! has target end location axon relationship: RO:0002339 GO:0030424 ! has target end location axon [Term] id: GO:0099622 name: cardiac muscle cell membrane repolarization namespace: biological_process def: "The process in which ions are transported across the plasma membrane of a cardiac muscle cell such that the membrane potential changes in the repolarizing direction, toward the steady state potential. For example, the repolarization during an action potential is from a positive membrane potential towards a negative resting potential." [GOC:BHF] is_a: GO:0086009 ! membrane repolarization intersection_of: GO:0086009 ! membrane repolarization intersection_of: BFO:0000066 CL:0000746 ! occurs in cardiac muscle cell relationship: BFO:0000066 CL:0000746 ! occurs in cardiac muscle cell relationship: RO:0002162 NCBITaxon:33208 ! in taxon Metazoa [Term] id: GO:0099623 name: regulation of cardiac muscle cell membrane repolarization namespace: biological_process def: "Any process that modulates the establishment or extent of a change in membrane potential in the polarizing direction towards the resting potential in a cardiomyocyte." [GOC:BHF, GOC:dos, GOC:rl] synonym: "heart repolarization" RELATED [] synonym: "regulation of cardiac muscle cell repolarization" EXACT [] synonym: "regulation of cardiomyocyte membrane repolarization" EXACT [] is_a: GO:0060306 ! regulation of membrane repolarization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0099622 ! regulates cardiac muscle cell membrane repolarization relationship: RO:0002211 GO:0099622 ! regulates cardiac muscle cell membrane repolarization [Term] id: GO:0099624 name: atrial cardiac muscle cell membrane repolarization namespace: biological_process def: "The process in which ions are transported across the plasma membrane of an atrial cardiac muscle cell such that the membrane potential changes in the repolarizing direction, toward the steady state potential. For example, the repolarization during an action potential is from a positive membrane potential towards a negative resting potential." [GOC:BHF] is_a: GO:0099622 ! cardiac muscle cell membrane repolarization intersection_of: GO:0086009 ! membrane repolarization intersection_of: BFO:0000066 CL:0002129 ! occurs in regular atrial cardiac myocyte relationship: BFO:0000066 CL:0002129 ! occurs in regular atrial cardiac myocyte [Term] id: GO:0099625 name: ventricular cardiac muscle cell membrane repolarization namespace: biological_process def: "The process in which ions are transported across the plasma membrane of a ventricular cardiac muscle cell such that the membrane potential changes in the repolarizing direction, toward the steady state potential. For example, the repolarization during an action potential is from a positive membrane potential towards a negative resting potential." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] is_a: GO:0099622 ! cardiac muscle cell membrane repolarization intersection_of: GO:0086009 ! membrane repolarization intersection_of: BFO:0000066 CL:0002131 ! occurs in regular ventricular cardiac myocyte relationship: BFO:0000066 CL:0002131 ! occurs in regular ventricular cardiac myocyte [Term] id: GO:0099632 name: protein transport within plasma membrane namespace: biological_process def: "A process in which protein is transported from one region of the plasma membrane to another." [GOC:dos] is_a: GO:0032594 ! protein transport within lipid bilayer intersection_of: GO:0006810 ! transport intersection_of: BFO:0000066 GO:0005886 ! occurs in plasma membrane intersection_of: RO:0004009 PR:000000001 ! has primary input protein relationship: BFO:0000066 GO:0005886 ! occurs in plasma membrane [Term] id: GO:0099635 name: voltage-gated calcium channel activity involved in positive regulation of presynaptic cytosolic calcium levels namespace: molecular_function def: "Positive regulation of presynaptic cytosolic calcium ion concentrations via the directed movement of calcium ions across the plasma-membrane into the cytosol via the action of voltage-gated calcium ion channels. This is the first step in synaptic transmission." [GOC:dos] subset: goslim_synapse xref: Reactome:R-HSA-9659515 "CACNA1D:CACNA2D2:CACNB2 (Cav1.3 channel) transports Ca2+ into the cytosol of an inner hair cell" is_a: GO:0005245 ! voltage-gated calcium channel activity intersection_of: GO:0005245 ! voltage-gated calcium channel activity intersection_of: BFO:0000050 GO:0099533 ! part of positive regulation of presynaptic cytosolic calcium concentration relationship: BFO:0000050 GO:0099703 ! part of induction of synaptic vesicle exocytosis by positive regulation of presynaptic cytosolic calcium ion concentration [Term] id: GO:0099637 name: neurotransmitter receptor transport namespace: biological_process def: "The directed movement of neurotransmitter receptors." [GOC:dos] subset: goslim_synapse is_a: GO:0015031 ! protein transport is_a: GO:0031503 ! protein-containing complex localization intersection_of: GO:0015031 ! protein transport intersection_of: RO:0004009 GO:0098878 ! has primary input neurotransmitter receptor complex relationship: RO:0004009 GO:0098878 ! has primary input neurotransmitter receptor complex [Term] id: GO:0099640 name: axo-dendritic protein transport namespace: biological_process def: "The directed movement of proteins along microtubules in neuron projections." [ISBN:0815316194] subset: goslim_synapse synonym: "axonal protein transport" NARROW [] is_a: GO:0008088 ! axo-dendritic transport is_a: GO:0098840 ! protein transport along microtubule intersection_of: GO:0046907 ! intracellular transport intersection_of: BFO:0000066 GO:0043005 ! occurs in neuron projection intersection_of: RO:0002341 GO:0005874 ! results in transport along microtubule intersection_of: RO:0004009 PR:000000001 ! has primary input protein [Term] id: GO:0099641 name: anterograde axonal protein transport namespace: biological_process def: "The directed movement of proteins along microtubules from the cell body toward the cell periphery in nerve cell axons." [GOC:dos] subset: goslim_synapse synonym: "anterograde axon cargo transport" BROAD [] is_a: GO:0008089 ! anterograde axonal transport is_a: GO:0099640 ! axo-dendritic protein transport is_a: GO:1905383 ! protein localization to presynapse intersection_of: GO:0006810 ! transport intersection_of: BFO:0000066 GO:1904115 ! occurs in axon cytoplasm intersection_of: RO:0002339 GO:0098793 ! has target end location presynapse intersection_of: RO:0002341 GO:0005874 ! results in transport along microtubule intersection_of: RO:0004009 PR:000000001 ! has primary input protein [Term] id: GO:0099642 name: retrograde axonal protein transport namespace: biological_process def: "The directed movement of proteins along microtubules from the cell periphery toward the cell body in nerve cell axons." [ISBN:0815316194] subset: goslim_synapse synonym: "retrograde axon cargo transport" BROAD [] is_a: GO:0008090 ! retrograde axonal transport is_a: GO:0099640 ! axo-dendritic protein transport intersection_of: GO:0006810 ! transport intersection_of: BFO:0000066 GO:1904115 ! occurs in axon cytoplasm intersection_of: RO:0002338 GO:0098793 ! has target start location presynapse intersection_of: RO:0002341 GO:0005874 ! results in transport along microtubule intersection_of: RO:0004009 PR:000000001 ! has primary input protein [Term] id: GO:0099643 name: signal release from synapse namespace: biological_process def: "Any signal release from a synapse." [GOC:dos] subset: goslim_synapse is_a: GO:0023061 ! signal release intersection_of: GO:0023061 ! signal release intersection_of: BFO:0000066 GO:0045202 ! occurs in synapse relationship: BFO:0000050 GO:0099536 ! part of synaptic signaling [Term] id: GO:0099703 name: induction of synaptic vesicle exocytosis by positive regulation of presynaptic cytosolic calcium ion concentration namespace: biological_process def: "The induction of synaptic vesicle release by any process that leads to a rise in intracellular calcium ion concentration at the presynapse. This is the first step in synaptic transmission." [GOC:dos, ISBN:9780071120005] subset: goslim_synapse is_a: GO:0099171 ! presynaptic modulation of chemical synaptic transmission is_a: GO:0099533 ! positive regulation of presynaptic cytosolic calcium concentration is_a: GO:2000302 ! positive regulation of synaptic vesicle exocytosis intersection_of: GO:0099533 ! positive regulation of presynaptic cytosolic calcium concentration intersection_of: RO:0002213 GO:0016079 ! positively regulates synaptic vesicle exocytosis relationship: BFO:0000050 GO:0007268 ! part of chemical synaptic transmission [Term] id: GO:0099738 name: cell cortex region namespace: cellular_component def: "The complete extent of cell cortex that underlies some some region of the plasma membrane." [GOC:dos] subset: gocheck_do_not_annotate synonym: "perimembrane region" EXACT [] is_a: GO:0005938 ! cell cortex is_a: GO:0099568 ! cytoplasmic region intersection_of: GO:0005938 ! cell cortex intersection_of: BFO:0000050 GO:0005938 ! part of cell cortex relationship: BFO:0000050 GO:0005938 ! part of cell cortex [Term] id: GO:0100001 name: regulation of skeletal muscle contraction by action potential namespace: biological_process def: "Any action potential process that regulates skeletal muscle contraction." [GOC:cjm, GOC:obol] is_a: GO:0001508 ! action potential is_a: GO:0014819 ! regulation of skeletal muscle contraction intersection_of: GO:0001508 ! action potential intersection_of: RO:0002211 GO:0003009 ! regulates skeletal muscle contraction creation_date: 2015-04-02T04:13:19Z [Term] id: GO:0101010 name: pulmonary blood vessel remodeling namespace: biological_process def: "The reorganization or renovation of existing pulmonary blood vessels." [GOC:mec] synonym: "pulmonary blood vessel remodelling" EXACT [] is_a: BFO:0000003 is_a: GO:0001974 ! blood vessel remodeling intersection_of: GO:0001974 ! blood vessel remodeling intersection_of: BFO:0000066 UBERON:0008886 ! occurs in pulmonary vascular system relationship: BFO:0000066 UBERON:0008886 ! occurs in pulmonary vascular system property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 [Term] id: GO:0101023 name: vascular endothelial cell proliferation namespace: biological_process def: "The multiplication or reproduction of blood vessel endothelial cells, resulting in the expansion of a cell population." [GOC:BHF, GOC:BHF_telomere, GOC:nc, PMID:23201774] is_a: GO:0001935 ! endothelial cell proliferation intersection_of: GO:0008283 ! cell population proliferation intersection_of: RO:0012003 CL:0000071 ! acts on population of blood vessel endothelial cell relationship: RO:0012003 CL:0000071 ! acts on population of blood vessel endothelial cell property_value: RO:0002161 NCBITaxon:4751 [Term] id: GO:0101024 name: mitotic nuclear membrane organization namespace: biological_process def: "A mitotic cell cycle process which results in the assembly, arrangement, or disassembly of the nuclear inner or outer membrane during mitosis." [GOC:vw, PMID:15147872] comment: This process only occurs in organisms which undergo 'closed mitosis' without nuclear breakdown. synonym: "nuclear membrane organization involved in mitotic nuclear division" EXACT [] is_a: GO:0071763 ! nuclear membrane organization is_a: GO:1903047 ! mitotic cell cycle process intersection_of: GO:0071763 ! nuclear membrane organization intersection_of: BFO:0000050 GO:0140014 ! part of mitotic nuclear division relationship: BFO:0000050 GO:0140014 ! part of mitotic nuclear division property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/19949" xsd:anyURI [Term] id: GO:0101025 name: nuclear membrane biogenesis namespace: biological_process def: "The process in which a nuclear membrane is synthesized, aggregates, and bonds together." [GOC:vw] is_a: GO:0044091 ! membrane biogenesis intersection_of: GO:0044085 ! cellular component biogenesis intersection_of: RO:0004008 GO:0031965 ! has primary output nuclear membrane relationship: BFO:0000050 GO:0071763 ! part of nuclear membrane organization relationship: RO:0004008 GO:0031965 ! has primary output nuclear membrane [Term] id: GO:0104004 name: cellular response to environmental stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an environmental stimulus." [GOC:dos] is_a: GO:0051716 ! cellular response to stimulus creation_date: 2017-02-17T16:02:42Z [Term] id: GO:0106014 name: regulation of inflammatory response to wounding namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the inflammatory response to wounding." [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:26022821] is_a: GO:0050727 ! regulation of inflammatory response is_a: GO:1903034 ! regulation of response to wounding intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0090594 ! regulates inflammatory response to wounding relationship: RO:0002211 GO:0090594 ! regulates inflammatory response to wounding creation_date: 2017-04-28T20:03:14Z [Term] id: GO:0106015 name: negative regulation of inflammatory response to wounding namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the inflammatory response to wounding." [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:26022821] is_a: GO:0050728 ! negative regulation of inflammatory response is_a: GO:0106014 ! regulation of inflammatory response to wounding is_a: GO:1903035 ! negative regulation of response to wounding intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0090594 ! negatively regulates inflammatory response to wounding relationship: RO:0002212 GO:0090594 ! negatively regulates inflammatory response to wounding creation_date: 2017-04-28T20:09:46Z [Term] id: GO:0106016 name: positive regulation of inflammatory response to wounding namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the inflammatory response to wounding." [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:26022821] is_a: GO:0050729 ! positive regulation of inflammatory response is_a: GO:0106014 ! regulation of inflammatory response to wounding is_a: GO:1903036 ! positive regulation of response to wounding intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0090594 ! positively regulates inflammatory response to wounding relationship: RO:0002213 GO:0090594 ! positively regulates inflammatory response to wounding creation_date: 2017-04-28T20:16:31Z [Term] id: GO:0106027 name: neuron projection organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a prolongation or process extending from a neuron, e.g. an axon, or a dendrite." [GOC:aruk, GOC:bc, PMID:11585923] is_a: GO:0120036 ! plasma membrane bounded cell projection organization intersection_of: GO:0016043 ! cellular component organization intersection_of: RO:0002592 GO:0043005 ! results in organization of neuron projection relationship: RO:0002592 GO:0043005 ! results in organization of neuron projection creation_date: 2017-06-23T18:30:18Z [Term] id: GO:0106134 name: positive regulation of cardiac muscle cell contraction namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cardiac muscle cell contraction." [PMID:19525381] is_a: GO:0086004 ! regulation of cardiac muscle cell contraction is_a: GO:1903116 ! positive regulation of actin filament-based movement intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0086003 ! positively regulates cardiac muscle cell contraction relationship: RO:0002213 GO:0086003 ! positively regulates cardiac muscle cell contraction property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 creation_date: 2018-07-26T16:05:16Z [Term] id: GO:0106135 name: negative regulation of cardiac muscle cell contraction namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cardiac muscle cell contraction." [PMID:19525381] is_a: GO:0048523 ! negative regulation of cellular process is_a: GO:0055118 ! negative regulation of cardiac muscle contraction is_a: GO:0086004 ! regulation of cardiac muscle cell contraction intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0086003 ! negatively regulates cardiac muscle cell contraction relationship: RO:0002212 GO:0086003 ! negatively regulates cardiac muscle cell contraction property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 creation_date: 2018-07-26T16:10:17Z [Term] id: GO:0106214 name: regulation of vesicle fusion with Golgi apparatus namespace: biological_process def: "Any process that modulates the frequency, rate or extent of vesicle fusion with Golgi apparatus." [GOC:se, PMID:26195667] is_a: GO:0031338 ! regulation of vesicle fusion is_a: GO:1903358 ! regulation of Golgi organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0048280 ! regulates vesicle fusion with Golgi apparatus relationship: RO:0002211 GO:0048280 ! regulates vesicle fusion with Golgi apparatus creation_date: 2019-06-27T15:12:22Z [Term] id: GO:0106215 name: negative regulation of vesicle fusion with Golgi apparatus namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of vesicle fustion with Golgi apparatus." [GOC:se, PMID:26195667] is_a: GO:0031339 ! negative regulation of vesicle fusion is_a: GO:0106214 ! regulation of vesicle fusion with Golgi apparatus intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0048280 ! negatively regulates vesicle fusion with Golgi apparatus relationship: RO:0002212 GO:0048280 ! negatively regulates vesicle fusion with Golgi apparatus creation_date: 2019-06-27T15:17:17Z [Term] id: GO:0106216 name: positive regulation of vesicle fusion with Golgi apparatus namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of vesicle fusion with Golgi apparatus." [GOC:se, PMID:26195667] is_a: GO:0031340 ! positive regulation of vesicle fusion is_a: GO:0106214 ! regulation of vesicle fusion with Golgi apparatus intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0048280 ! positively regulates vesicle fusion with Golgi apparatus relationship: RO:0002213 GO:0048280 ! positively regulates vesicle fusion with Golgi apparatus creation_date: 2019-06-27T15:20:59Z [Term] id: GO:0106426 name: regulation of kainate selective glutamate receptor signaling pathway namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the kainate selective glutamate receptor signaling pathway." [PMID:12597860] is_a: GO:1900449 ! regulation of glutamate receptor signaling pathway intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0098991 ! regulates kainate selective glutamate receptor signaling pathway relationship: RO:0002211 GO:0098991 ! regulates kainate selective glutamate receptor signaling pathway creation_date: 2022-07-06T18:26:41Z [Term] id: GO:0106427 name: negative regulation of kainate selective glutamate receptor signaling pathway namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of the kainate selective glutamate receptor signaling pathway." [PMID:12597860] is_a: GO:0048519 ! negative regulation of biological process is_a: GO:0106426 ! regulation of kainate selective glutamate receptor signaling pathway intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0106426 ! negatively regulates regulation of kainate selective glutamate receptor signaling pathway relationship: RO:0002212 GO:0106426 ! negatively regulates regulation of kainate selective glutamate receptor signaling pathway creation_date: 2022-07-06T18:32:46Z [Term] id: GO:0106428 name: positive regulation of kainate selective glutamate receptor signaling pathway namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the kainate selective glutamate receptor signaling pathway." [PMID:12597860] is_a: GO:0048518 ! positive regulation of biological process is_a: GO:0106426 ! regulation of kainate selective glutamate receptor signaling pathway intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0106426 ! positively regulates regulation of kainate selective glutamate receptor signaling pathway relationship: RO:0002213 GO:0106426 ! positively regulates regulation of kainate selective glutamate receptor signaling pathway property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/23558" xsd:anyURI creation_date: 2022-07-06T18:36:50Z [Term] id: GO:0110011 name: regulation of basement membrane organization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the assembly, disassembly or arrangement of constituent parts of the basement membrane." [GOC:ha, PMID:27404358] is_a: GO:1903053 ! regulation of extracellular matrix organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0071711 ! regulates basement membrane organization relationship: RO:0002211 GO:0071711 ! regulates basement membrane organization [Term] id: GO:0110020 name: regulation of actomyosin structure organization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures containing both actin and myosin or paramyosin." [GOC:lf, PMID:22790195] is_a: GO:0032956 ! regulation of actin cytoskeleton organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0031032 ! regulates actomyosin structure organization relationship: RO:0002211 GO:0031032 ! regulates actomyosin structure organization creation_date: 2017-06-20T19:28:58Z [Term] id: GO:0110021 name: cardiac muscle myoblast proliferation namespace: biological_process def: "The multiplication or reproduction of cardiac muscle myoblasts, resulting in the expansion of a cardiac muscle myoblast cell population. A cardiac myoblast is a precursor cell that has been committed to a cardiac muscle cell fate but retains the ability to divide and proliferate throughout life." [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:26512644] is_a: GO:0051450 ! myoblast proliferation intersection_of: GO:0008283 ! cell population proliferation intersection_of: RO:0012003 CL:0000513 ! acts on population of cardiac muscle myoblast relationship: RO:0012003 CL:0000513 ! acts on population of cardiac muscle myoblast property_value: RO:0002161 NCBITaxon:4751 creation_date: 2017-06-29T14:35:24Z [Term] id: GO:0110022 name: regulation of cardiac muscle myoblast proliferation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cardiac muscle myoblast proliferation." [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:26512644] is_a: GO:2000291 ! regulation of myoblast proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0110021 ! regulates cardiac muscle myoblast proliferation relationship: RO:0002211 GO:0110021 ! regulates cardiac muscle myoblast proliferation property_value: RO:0002161 NCBITaxon:4751 creation_date: 2017-06-29T15:11:47Z [Term] id: GO:0110023 name: negative regulation of cardiac muscle myoblast proliferation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cardiac muscle myoblast proliferation." [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:26512644] is_a: GO:0110022 ! regulation of cardiac muscle myoblast proliferation is_a: GO:2000818 ! negative regulation of myoblast proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0110021 ! negatively regulates cardiac muscle myoblast proliferation relationship: RO:0002212 GO:0110021 ! negatively regulates cardiac muscle myoblast proliferation property_value: RO:0002161 NCBITaxon:4751 creation_date: 2017-06-29T15:18:30Z [Term] id: GO:0110024 name: positive regulation of cardiac muscle myoblast proliferation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cardiac muscle myoblast proliferation." [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:26512644] is_a: GO:0110022 ! regulation of cardiac muscle myoblast proliferation is_a: GO:2000288 ! positive regulation of myoblast proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0110021 ! positively regulates cardiac muscle myoblast proliferation relationship: RO:0002213 GO:0110021 ! positively regulates cardiac muscle myoblast proliferation property_value: RO:0002161 NCBITaxon:4751 creation_date: 2017-06-29T15:24:16Z [Term] id: GO:0110053 name: regulation of actin filament organization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of actin filament organization." [GOC:kmv] is_a: GO:0032956 ! regulation of actin cytoskeleton organization is_a: GO:1902903 ! regulation of supramolecular fiber organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0007015 ! regulates actin filament organization relationship: RO:0002211 GO:0007015 ! regulates actin filament organization creation_date: 2017-09-20T19:52:57Z [Term] id: GO:0110057 name: regulation of blood vessel endothelial cell differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of blood vessel endothelial cell differentiation." [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:23072816] is_a: GO:0045601 ! regulation of endothelial cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0060837 ! regulates blood vessel endothelial cell differentiation relationship: RO:0002211 GO:0060837 ! regulates blood vessel endothelial cell differentiation creation_date: 2017-10-23T14:32:09Z [Term] id: GO:0110058 name: positive regulation of blood vessel endothelial cell differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of blood vessel endothelial cell differentiation." [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:23072816] is_a: GO:0045603 ! positive regulation of endothelial cell differentiation is_a: GO:0110057 ! regulation of blood vessel endothelial cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0060837 ! positively regulates blood vessel endothelial cell differentiation relationship: RO:0002213 GO:0060837 ! positively regulates blood vessel endothelial cell differentiation creation_date: 2017-10-23T14:38:19Z [Term] id: GO:0110059 name: negative regulation of blood vessel endothelial cell differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of blood vessel endothelial cell differentiation." [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:23072816] is_a: GO:0045602 ! negative regulation of endothelial cell differentiation is_a: GO:0110057 ! regulation of blood vessel endothelial cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0060837 ! negatively regulates blood vessel endothelial cell differentiation relationship: RO:0002212 GO:0060837 ! negatively regulates blood vessel endothelial cell differentiation creation_date: 2017-10-23T14:47:29Z [Term] id: GO:0110067 name: ammonium transmembrane transporter complex namespace: cellular_component def: "High affinity ammonium transporter complex that enables the transfer of ammonium from one side of a membrane to the other." [GOC:bhm, PMID:17026539, PMID:23463773] synonym: "AMT1 complex" NARROW [GOC:bhm] is_a: GO:1902495 ! transmembrane transporter complex intersection_of: GO:0032991 ! protein-containing complex intersection_of: RO:0002215 GO:0008519 ! capable of ammonium channel activity relationship: RO:0002215 GO:0008519 ! capable of ammonium channel activity relationship: RO:0002216 GO:0072488 ! capable of part of ammonium transmembrane transport creation_date: 2017-11-20T15:21:10Z [Term] id: GO:0110077 name: vesicle-mediated intercellular transport namespace: biological_process def: "A cellular transport process in which transported substances are moved in extracellular vesicles between cells; transported substances are enclosed in the vesicle lumen or located in the extracellular vesicle membrane." [GOC:sp, PMID:29328915, PMID:29328916] synonym: "endosomal trafficking" RELATED [] is_a: GO:0010496 ! intercellular transport is_a: GO:0016192 ! vesicle-mediated transport intersection_of: GO:0010496 ! intercellular transport intersection_of: RO:0002608 GO:1903561 ! process has causal agent extracellular vesicle relationship: RO:0002608 GO:1903561 ! process has causal agent extracellular vesicle creation_date: 2018-01-29T14:46:52Z [Term] id: GO:0110079 name: regulation of placenta blood vessel development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of placenta blood vessel development." [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:27748453] is_a: GO:1901342 ! regulation of vasculature development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0060674 ! regulates placenta blood vessel development relationship: RO:0002211 GO:0060674 ! regulates placenta blood vessel development creation_date: 2018-02-01T14:49:12Z [Term] id: GO:0110080 name: positive regulation of placenta blood vessel development namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of placenta blood vessel development." [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:27748453] is_a: GO:0051094 ! positive regulation of developmental process is_a: GO:0110079 ! regulation of placenta blood vessel development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0060674 ! positively regulates placenta blood vessel development relationship: RO:0002213 GO:0060674 ! positively regulates placenta blood vessel development creation_date: 2018-02-01T14:55:30Z [Term] id: GO:0110081 name: negative regulation of placenta blood vessel development namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of placenta blood vessel development." [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:27748453] is_a: GO:0051093 ! negative regulation of developmental process is_a: GO:0110079 ! regulation of placenta blood vessel development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0060674 ! negatively regulates placenta blood vessel development relationship: RO:0002212 GO:0060674 ! negatively regulates placenta blood vessel development creation_date: 2018-02-01T15:01:11Z [Term] id: GO:0110088 name: hippocampal neuron apoptotic process namespace: biological_process def: "Any apoptotic process that occurs in a hippocampal neuron." [GOC:sl, PMID:18940801] is_a: GO:0051402 ! neuron apoptotic process intersection_of: GO:0006915 ! apoptotic process intersection_of: BFO:0000066 CL:0002608 ! occurs in hippocampal neuron relationship: BFO:0000066 CL:0002608 ! occurs in hippocampal neuron property_value: RO:0002161 NCBITaxon:4896 creation_date: 2018-02-13T21:06:23Z [Term] id: GO:0110089 name: regulation of hippocampal neuron apoptotic process namespace: biological_process def: "Any process that modulates the occurrence or rate of cell death by apoptotic process in hippocampal neurons." [GOC:sl, PMID:18940801] is_a: GO:0043523 ! regulation of neuron apoptotic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0110088 ! regulates hippocampal neuron apoptotic process relationship: RO:0002211 GO:0110088 ! regulates hippocampal neuron apoptotic process property_value: RO:0002161 NCBITaxon:4896 creation_date: 2018-02-13T21:18:29Z [Term] id: GO:0110090 name: positive regulation of hippocampal neuron apoptotic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process in hippocampal neurons." [GOC:sl, PMID:18940801] is_a: GO:0043525 ! positive regulation of neuron apoptotic process is_a: GO:0110089 ! regulation of hippocampal neuron apoptotic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0110088 ! positively regulates hippocampal neuron apoptotic process relationship: RO:0002213 GO:0110088 ! positively regulates hippocampal neuron apoptotic process property_value: RO:0002161 NCBITaxon:4896 creation_date: 2018-02-13T21:22:18Z [Term] id: GO:0110091 name: negative regulation of hippocampal neuron apoptotic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process in hippocampal neurons." [GOC:sl, PMID:18940801] is_a: GO:0043524 ! negative regulation of neuron apoptotic process is_a: GO:0110089 ! regulation of hippocampal neuron apoptotic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0110088 ! negatively regulates hippocampal neuron apoptotic process relationship: RO:0002212 GO:0110088 ! negatively regulates hippocampal neuron apoptotic process property_value: RO:0002161 NCBITaxon:4896 creation_date: 2018-02-13T21:25:01Z [Term] id: GO:0110095 name: cellular detoxification of aldehyde namespace: biological_process def: "Any process carried out at the cellular level that reduces or removes the toxicity of an aldehyde. These may include transport of aldehydes away from sensitive areas and to compartments or complexes whose purpose is sequestration of the toxic substance." [GOC:vw, PMID:25656103] is_a: GO:1990748 ! cellular detoxification intersection_of: GO:1990748 ! cellular detoxification intersection_of: RO:0004009 CHEBI:17478 ! has primary input relationship: BFO:0000050 GO:0110096 ! part of cellular response to aldehyde relationship: RO:0004009 CHEBI:17478 ! has primary input creation_date: 2018-02-16T21:19:20Z [Term] id: GO:0110096 name: cellular response to aldehyde namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an aldehyde stimulus." [GOC:vw, PMID:25656103] is_a: GO:1901701 ! cellular response to oxygen-containing compound intersection_of: GO:0070887 ! cellular response to chemical stimulus intersection_of: RO:0004009 CHEBI:17478 ! has primary input relationship: RO:0004009 CHEBI:17478 ! has primary input creation_date: 2018-02-16T21:29:18Z [Term] id: GO:0110097 name: regulation of calcium import into the mitochondrion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of calcium import into the mitochondrion." [GOC:sl, PMID:24085037] is_a: GO:1903169 ! regulation of calcium ion transmembrane transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0036444 ! regulates calcium import into the mitochondrion relationship: RO:0002211 GO:0036444 ! regulates calcium import into the mitochondrion creation_date: 2018-02-28T00:33:51Z [Term] id: GO:0110098 name: positive regulation of calcium import into the mitochondrion namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of calcium import into the mitochondrion." [GOC:sl, PMID:24085037] is_a: GO:0110097 ! regulation of calcium import into the mitochondrion is_a: GO:1904427 ! positive regulation of calcium ion transmembrane transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0036444 ! positively regulates calcium import into the mitochondrion relationship: RO:0002213 GO:0036444 ! positively regulates calcium import into the mitochondrion creation_date: 2018-02-28T00:39:13Z [Term] id: GO:0110099 name: negative regulation of calcium import into the mitochondrion namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of calcium ion import into the mitochondrion." [GOC:sl, PMID:24085037] is_a: GO:0110097 ! regulation of calcium import into the mitochondrion is_a: GO:1903170 ! negative regulation of calcium ion transmembrane transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0036444 ! negatively regulates calcium import into the mitochondrion relationship: RO:0002212 GO:0036444 ! negatively regulates calcium import into the mitochondrion creation_date: 2018-02-28T00:42:06Z [Term] id: GO:0110110 name: positive regulation of animal organ morphogenesis namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of animal organ morphogenesis." [GOC:kmv] is_a: GO:0051094 ! positive regulation of developmental process is_a: GO:0051240 ! positive regulation of multicellular organismal process is_a: GO:2000027 ! regulation of animal organ morphogenesis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0009887 ! positively regulates animal organ morphogenesis relationship: RO:0002213 GO:0009887 ! positively regulates animal organ morphogenesis creation_date: 2018-07-05T14:10:14Z [Term] id: GO:0110111 name: negative regulation of animal organ morphogenesis namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of animal organ morphogenesis." [GOC:kmv] is_a: GO:0051093 ! negative regulation of developmental process is_a: GO:0051241 ! negative regulation of multicellular organismal process is_a: GO:2000027 ! regulation of animal organ morphogenesis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0009887 ! negatively regulates animal organ morphogenesis relationship: RO:0002212 GO:0009887 ! negatively regulates animal organ morphogenesis creation_date: 2018-07-05T14:25:21Z [Term] id: GO:0110116 name: regulation of compound eye photoreceptor cell differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of compound eye photoreceptor cell differentiation." [GOC:ha, PMID:16377567] is_a: GO:0046532 ! regulation of photoreceptor cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0001751 ! regulates compound eye photoreceptor cell differentiation relationship: RO:0002211 GO:0001751 ! regulates compound eye photoreceptor cell differentiation creation_date: 2018-07-16T18:08:49Z [Term] id: GO:0110117 name: positive regulation of compound eye photoreceptor cell differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of compound eye photoreceptor cell differentiation." [GOC:ha, PMID:16377567] is_a: GO:0046534 ! positive regulation of photoreceptor cell differentiation is_a: GO:0110116 ! regulation of compound eye photoreceptor cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0001751 ! positively regulates compound eye photoreceptor cell differentiation relationship: RO:0002213 GO:0001751 ! positively regulates compound eye photoreceptor cell differentiation creation_date: 2018-07-16T18:13:28Z [Term] id: GO:0110118 name: negative regulation of compound eye photoreceptor cell differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of compound eye photoreceptor cell differentiation." [GOC:ha, PMID:16377567] is_a: GO:0046533 ! negative regulation of photoreceptor cell differentiation is_a: GO:0110116 ! regulation of compound eye photoreceptor cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0001751 ! negatively regulates compound eye photoreceptor cell differentiation relationship: RO:0002212 GO:0001751 ! negatively regulates compound eye photoreceptor cell differentiation creation_date: 2018-07-16T18:15:52Z [Term] id: GO:0110122 name: myotube cell migration namespace: biological_process def: "The orderly movement of a myotube cell from one site to another, often during the development of a multicellular organism. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate, and fuse." [GOC:ha, PMID:29122742] is_a: GO:0014812 ! muscle cell migration intersection_of: GO:0016477 ! cell migration intersection_of: RO:0002565 CL:0002372 ! results in movement of myotube relationship: RO:0002565 CL:0002372 ! results in movement of myotube property_value: RO:0002161 NCBITaxon:4890 creation_date: 2018-08-22T20:58:09Z [Term] id: GO:0110123 name: regulation of myotube cell migration namespace: biological_process def: "Any process that modulates the frequency, rate or extent of myotube cell migration." [GOC:ha, PMID:29122742] is_a: GO:0030334 ! regulation of cell migration intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0110122 ! regulates myotube cell migration relationship: RO:0002211 GO:0110122 ! regulates myotube cell migration property_value: RO:0002161 NCBITaxon:451864 creation_date: 2018-08-22T21:06:53Z [Term] id: GO:0110124 name: positive regulation of myotube cell migration namespace: biological_process def: "Any process that activates, maintains or increases the frequency, rate or extent of myotube cell migration." [GOC:ha, PMID:29122742] is_a: GO:0030335 ! positive regulation of cell migration is_a: GO:0110123 ! regulation of myotube cell migration intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0110122 ! positively regulates myotube cell migration relationship: RO:0002213 GO:0110122 ! positively regulates myotube cell migration property_value: RO:0002161 NCBITaxon:451864 creation_date: 2018-08-22T21:09:38Z [Term] id: GO:0110125 name: negative regulation of myotube cell migration namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of myotube cell migration." [GOC:ha, PMID:29122742] is_a: GO:0030336 ! negative regulation of cell migration is_a: GO:0110123 ! regulation of myotube cell migration intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0110122 ! negatively regulates myotube cell migration relationship: RO:0002212 GO:0110122 ! negatively regulates myotube cell migration property_value: RO:0002161 NCBITaxon:451864 creation_date: 2018-08-22T21:12:47Z [Term] id: GO:0110141 name: L-glutamate import into mitochondrion namespace: biological_process def: "The process in which L-glutamate is transported from the cytosol into the mitochondrial matrix." [GOC:vw, PMID:30297026] is_a: GO:0015813 ! L-glutamate transmembrane transport intersection_of: GO:0006810 ! transport intersection_of: RO:0002338 GO:0005829 ! has target start location cytosol intersection_of: RO:0002339 GO:0005759 ! has target end location mitochondrial matrix intersection_of: RO:0002342 GO:0031966 ! results in transport across mitochondrial membrane intersection_of: RO:0004009 CHEBI:29985 ! has primary input relationship: RO:0002338 GO:0005829 ! has target start location cytosol relationship: RO:0002339 GO:0005759 ! has target end location mitochondrial matrix relationship: RO:0002342 GO:0031966 ! results in transport across mitochondrial membrane creation_date: 2019-04-24T19:13:46Z [Term] id: GO:0110165 name: cellular anatomical structure namespace: cellular_component def: "A part of a cellular organism consisting of a material entity with granularity above the level of a protein complex but below that of an anatomical system. Note that cellular organisms exclude viruses." [GOC:kmv] subset: gocheck_do_not_annotate subset: goslim_pir synonym: "cellular anatomical entity" EXACT [] is_a: CARO:0000000 is_a: GO:0005575 ! cellular_component is_a: UBERON:0000061 ! anatomical structure property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/24200" xsd:anyURI property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/26424" xsd:anyURI property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/28978" xsd:anyURI property_value: skos:prefLabel "cellular anatomical structure" xsd:string creation_date: 2019-08-12T18:01:37Z [Term] id: GO:0120006 name: regulation of glutamatergic neuron differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of glutamatergic neuron differentiation." [PMID:24030726] is_a: GO:0045664 ! regulation of neuron differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:1905962 ! regulates glutamatergic neuron differentiation relationship: RO:0002211 GO:1905962 ! regulates glutamatergic neuron differentiation property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/13107" xsd:anyURI creation_date: 2017-03-01T16:10:27Z [Term] id: GO:0120007 name: negative regulation of glutamatergic neuron differentiation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of glutamatergic neuron differentiation." [PMID:24030726] is_a: GO:0045665 ! negative regulation of neuron differentiation is_a: GO:0120006 ! regulation of glutamatergic neuron differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:1905962 ! negatively regulates glutamatergic neuron differentiation relationship: RO:0002212 GO:1905962 ! negatively regulates glutamatergic neuron differentiation property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/13107" xsd:anyURI creation_date: 2017-03-01T16:25:50Z [Term] id: GO:0120008 name: positive regulation of glutamatergic neuron differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of glutamatergic neuron differentiation." [PMID:24030726] is_a: GO:0045666 ! positive regulation of neuron differentiation is_a: GO:0120006 ! regulation of glutamatergic neuron differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:1905962 ! positively regulates glutamatergic neuron differentiation relationship: RO:0002213 GO:1905962 ! positively regulates glutamatergic neuron differentiation property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/13107" xsd:anyURI creation_date: 2017-03-01T16:35:45Z [Term] id: GO:0120023 name: somatostatin binding namespace: molecular_function def: "Binding to somatostatin, a polypeptide hormone involved in regulating pancreatic alpha and pancreatic beta cells and controlling growth hormone secretion as well as many other functions. Somatostatin is produced by several cell types including pancreatic delta cells. There are several different mature forms of somatostatin." [GOC:cvs, PMID:20472043] is_a: GO:0017046 ! peptide hormone binding intersection_of: GO:0005488 ! binding intersection_of: RO:0004009 CHEBI:64628 ! has primary input relationship: RO:0004009 CHEBI:64628 ! has primary input property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/13143" xsd:anyURI creation_date: 2017-03-17T14:54:21Z [Term] id: GO:0120025 name: plasma membrane bounded cell projection namespace: cellular_component def: "A prolongation or process extending from a cell and that is bounded by plasma membrane, e.g. a cilium, lamellipodium, or axon." [GOC:krc] is_a: GO:0042995 ! cell projection intersection_of: GO:0042995 ! cell projection intersection_of: BFO:0000051 GO:0098590 ! has part plasma membrane region relationship: BFO:0000051 GO:0098590 ! has part plasma membrane region property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/13193" xsd:anyURI property_value: skos:prefLabel "plasma membrane bounded cell projection" xsd:string creation_date: 2017-03-21T17:26:07Z [Term] id: GO:0120029 name: proton export across plasma membrane namespace: biological_process def: "The directed movement of hydrogen ions (protons) from inside a cell, across the plasma membrane and into the extracellular region." [GOC:mah, PMID:9762918] synonym: "hydrogen ion export across plasma membrane" EXACT [] synonym: "hydrogen ion export from cell" BROAD [] synonym: "proton export from cell" BROAD [] is_a: GO:0140115 ! export across plasma membrane is_a: GO:1902600 ! proton transmembrane transport intersection_of: GO:0006810 ! transport intersection_of: RO:0002338 GO:0005829 ! has target start location cytosol intersection_of: RO:0002339 GO:0005576 ! has target end location extracellular region intersection_of: RO:0002342 GO:0005886 ! results in transport across plasma membrane intersection_of: RO:0004009 CHEBI:15378 ! has primary input property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/13271" xsd:anyURI creation_date: 2017-03-31T17:39:03Z [Term] id: GO:0120031 name: plasma membrane bounded cell projection assembly namespace: biological_process def: "Formation of a prolongation or process extending and that is bounded by plasma membrane, e.g. a cilium, lamellipodium, or axon." [GOC:krc] synonym: "eupodium" NARROW [GOC:krc, GOC:rjd, PMID:10328951, PMID:9096956] is_a: GO:0030031 ! cell projection assembly is_a: GO:0120036 ! plasma membrane bounded cell projection organization intersection_of: GO:0022607 ! cellular component assembly intersection_of: RO:0002588 GO:0120025 ! results in assembly of plasma membrane bounded cell projection relationship: RO:0002588 GO:0120025 ! results in assembly of plasma membrane bounded cell projection property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/13298" xsd:anyURI creation_date: 2017-04-24T23:56:08Z [Term] id: GO:0120032 name: regulation of plasma membrane bounded cell projection assembly namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of plasma membrane bounded cell projection assembly." [GOC:krc] is_a: GO:0060491 ! regulation of cell projection assembly is_a: GO:0120035 ! regulation of plasma membrane bounded cell projection organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0120031 ! regulates plasma membrane bounded cell projection assembly relationship: RO:0002211 GO:0120031 ! regulates plasma membrane bounded cell projection assembly property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/13298" xsd:anyURI creation_date: 2017-04-26T04:27:04Z [Term] id: GO:0120033 name: negative regulation of plasma membrane bounded cell projection assembly namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of plasma membrane bounded cell projection assembly." [GOC:krc] is_a: GO:0031345 ! negative regulation of cell projection organization is_a: GO:0120032 ! regulation of plasma membrane bounded cell projection assembly intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0120031 ! negatively regulates plasma membrane bounded cell projection assembly relationship: RO:0002212 GO:0120031 ! negatively regulates plasma membrane bounded cell projection assembly property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/13298" xsd:anyURI creation_date: 2017-04-26T04:34:31Z [Term] id: GO:0120034 name: positive regulation of plasma membrane bounded cell projection assembly namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of plasma membrane bounded cell projection assembly." [GOC:krc] is_a: GO:0031346 ! positive regulation of cell projection organization is_a: GO:0044089 ! positive regulation of cellular component biogenesis is_a: GO:0120032 ! regulation of plasma membrane bounded cell projection assembly intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0120031 ! positively regulates plasma membrane bounded cell projection assembly relationship: RO:0002213 GO:0120031 ! positively regulates plasma membrane bounded cell projection assembly property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/13298" xsd:anyURI creation_date: 2017-04-26T04:34:45Z [Term] id: GO:0120035 name: regulation of plasma membrane bounded cell projection organization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of plasma membrane bounded cell projections." [GOC:krc] is_a: GO:0031344 ! regulation of cell projection organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0120036 ! regulates plasma membrane bounded cell projection organization relationship: RO:0002211 GO:0120036 ! regulates plasma membrane bounded cell projection organization property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/13298" xsd:anyURI creation_date: 2017-04-26T16:02:06Z [Term] id: GO:0120036 name: plasma membrane bounded cell projection organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a plasma membrane bounded prolongation or process extending from a cell, e.g. a cilium or axon." [GOC:krc] is_a: GO:0030030 ! cell projection organization intersection_of: GO:0016043 ! cellular component organization intersection_of: RO:0002592 GO:0120025 ! results in organization of plasma membrane bounded cell projection relationship: RO:0002592 GO:0120025 ! results in organization of plasma membrane bounded cell projection property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/13298" xsd:anyURI creation_date: 2017-04-26T16:07:02Z [Term] id: GO:0120039 name: plasma membrane bounded cell projection morphogenesis namespace: biological_process def: "The process in which the anatomical structures of a plasma membrane bounded cell projection are generated and organized." [GOC:krc] is_a: GO:0048858 ! cell projection morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 GO:0120025 ! results in morphogenesis of plasma membrane bounded cell projection relationship: RO:0002298 GO:0120025 ! results in morphogenesis of plasma membrane bounded cell projection property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/13298" xsd:anyURI creation_date: 2017-04-28T23:39:37Z [Term] id: GO:0120111 name: neuron projection cytoplasm namespace: cellular_component def: "All of the contents of a plasma membrane bounded neuron projection, excluding the plasma membrane surrounding the projection." [GOC:ha] is_a: GO:0032838 ! plasma membrane bounded cell projection cytoplasm intersection_of: GO:0005737 ! cytoplasm intersection_of: BFO:0000050 GO:0043005 ! part of neuron projection relationship: BFO:0000050 GO:0043005 ! part of neuron projection property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/14472" xsd:anyURI creation_date: 2017-11-01T18:58:12Z [Term] id: GO:0120116 name: glucagon processing namespace: biological_process def: "The formation of mature glucagon by proteolysis of the precursor proglucagon." [PMID:28719828] xref: Reactome:R-HSA-381771 "Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)" is_a: GO:0016486 ! peptide hormone processing intersection_of: GO:0016485 ! protein processing intersection_of: RO:0004007 CHEBI:5391 ! has primary input or output relationship: RO:0004007 CHEBI:5391 ! has primary input or output property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/14505" xsd:anyURI property_value: RO:0002161 NCBITaxon:4895 creation_date: 2017-11-08T19:31:42Z [Term] id: GO:0120158 name: positive regulation of collagen catabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of collagen catabolism. Collagen catabolism is the proteolytic chemical reactions and pathways resulting in the breakdown of collagen in the extracellular matrix." [GOC:dph, GOC:tb] synonym: "activation of collagen catabolic process" NARROW [GOC:dph, GOC:tb] synonym: "positive regulation of collagen breakdown" EXACT [GOC:dph, GOC:tb] synonym: "positive regulation of collagen catabolism" EXACT [GOC:dph, GOC:tb] synonym: "positive regulation of collagen degradation" EXACT [GOC:dph, GOC:tb] synonym: "up regulation of collagen catabolic process" EXACT [GOC:dph, GOC:tb] synonym: "up-regulation of collagen catabolic process" EXACT [GOC:dph, GOC:tb] synonym: "upregulation of collagen catabolic process" EXACT [GOC:dph, GOC:tb] is_a: GO:0009896 ! positive regulation of catabolic process is_a: GO:0010710 ! regulation of collagen catabolic process is_a: GO:0010714 ! positive regulation of collagen metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0030574 ! positively regulates collagen catabolic process relationship: RO:0002213 GO:0030574 ! positively regulates collagen catabolic process property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/15720" xsd:anyURI creation_date: 2018-05-11T16:31:42Z [Term] id: GO:0120178 name: steroid hormone biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of any steroid hormone, naturally occurring substances secreted by specialized cells that affects the metabolism or behavior of other cells possessing functional receptors for the hormone." [GOC:krc, GOC:nln] is_a: GO:0006694 ! steroid biosynthetic process intersection_of: GO:0006694 ! steroid biosynthetic process intersection_of: RO:0004008 CHEBI:26764 ! has primary output relationship: RO:0004008 CHEBI:26764 ! has primary output property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/16000" xsd:anyURI creation_date: 2019-05-20T22:34:00Z [Term] id: GO:0120180 name: cell-substrate junction disassembly namespace: biological_process def: "The disaggregation of a cell-substrate junction into its constituent components." [GOC:aruk, GOC:bc, PMID:25490267] is_a: GO:0150115 ! cell-substrate junction organization is_a: GO:0150146 ! cell junction disassembly intersection_of: GO:0022411 ! cellular component disassembly intersection_of: RO:0002590 GO:0030055 ! results in disassembly of cell-substrate junction relationship: RO:0002590 GO:0030055 ! results in disassembly of cell-substrate junction property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/15964" xsd:anyURI creation_date: 2018-07-12T17:33:35Z [Term] id: GO:0120186 name: negative regulation of protein localization to chromatin namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of protein localization to chromatin." [PMID:20889714, PMID:29899453] synonym: "negative regulation of protein localisation to chromatin" EXACT [GOC:krc] is_a: GO:1903828 ! negative regulation of protein localization is_a: GO:1905634 ! regulation of protein localization to chromatin intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0071168 ! negatively regulates protein localization to chromatin relationship: RO:0002212 GO:0071168 ! negatively regulates protein localization to chromatin property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/16012" xsd:anyURI creation_date: 2018-07-14T00:19:32Z [Term] id: GO:0120187 name: positive regulation of protein localization to chromatin namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of protein localization to chromatin." [PMID:20889714, PMID:29899453] synonym: "positive regulation of protein localisation to chromatin" EXACT [GOC:krc] is_a: GO:1903829 ! positive regulation of protein localization is_a: GO:1905634 ! regulation of protein localization to chromatin intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0071168 ! positively regulates protein localization to chromatin relationship: RO:0002213 GO:0071168 ! positively regulates protein localization to chromatin property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/16012" xsd:anyURI creation_date: 2018-07-14T00:21:28Z [Term] id: GO:0120188 name: regulation of bile acid secretion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the controlled release of bile acid from a cell or a tissue." [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:22767443] is_a: GO:0032890 ! regulation of organic acid transport is_a: GO:0051046 ! regulation of secretion intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0032782 ! regulates bile acid secretion relationship: RO:0002211 GO:0032782 ! regulates bile acid secretion property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/16040" xsd:anyURI creation_date: 2018-07-16T22:28:58Z [Term] id: GO:0120189 name: positive regulation of bile acid secretion namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the controlled release of bile acid from a cell or a tissue." [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:22767443] is_a: GO:0032892 ! positive regulation of organic acid transport is_a: GO:0051047 ! positive regulation of secretion is_a: GO:0120188 ! regulation of bile acid secretion intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0032782 ! positively regulates bile acid secretion relationship: RO:0002213 GO:0032782 ! positively regulates bile acid secretion property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/16040" xsd:anyURI creation_date: 2018-07-16T22:36:17Z [Term] id: GO:0120190 name: negative regulation of bile acid secretion namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of the controlled release of bile acid from a cell or a tissue." [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:22767443] is_a: GO:0032891 ! negative regulation of organic acid transport is_a: GO:0051048 ! negative regulation of secretion is_a: GO:0120188 ! regulation of bile acid secretion intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0032782 ! negatively regulates bile acid secretion relationship: RO:0002212 GO:0032782 ! negatively regulates bile acid secretion property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/16040" xsd:anyURI creation_date: 2018-07-16T22:38:34Z [Term] id: GO:0120192 name: tight junction assembly namespace: biological_process def: "A cellular process that results in the aggregation, arrangement and bonding together of a set of components to form a tight junction. A tight junction seals cells together in an epithelium in a way that prevents even small molecules from leaking from one side of the sheet to the other." [GOC:rl] synonym: "occluding cell junction assembly" EXACT [GOC:rl] synonym: "occluding junction assembly" EXACT [GOC:rl] is_a: GO:0007043 ! cell-cell junction assembly is_a: GO:0120193 ! tight junction organization intersection_of: GO:0022607 ! cellular component assembly intersection_of: RO:0002588 GO:0070160 ! results in assembly of tight junction relationship: RO:0002588 GO:0070160 ! results in assembly of tight junction property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/16187" xsd:anyURI property_value: RO:0002161 NCBITaxon:4751 creation_date: 2018-08-14T22:48:05Z [Term] id: GO:0120193 name: tight junction organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a tight junction. A tight junction seals cells together in an epithelium in a way that prevents even small molecules from leaking from one side of the sheet to the other." [GOC:krc, GOC:rl] synonym: "occluding cell junction organization" EXACT [GOC:rl] synonym: "occluding junction organization" EXACT [] is_a: GO:0045216 ! cell-cell junction organization intersection_of: GO:0016043 ! cellular component organization intersection_of: RO:0002592 GO:0070160 ! results in organization of tight junction relationship: RO:0002592 GO:0070160 ! results in organization of tight junction property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/16187" xsd:anyURI creation_date: 2018-08-14T23:05:40Z [Term] id: GO:0120213 name: regulation of histidine biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of histidine biosynthetic process." [GOC:krc] synonym: "regulation of histidine anabolism" EXACT [GOC:krc] synonym: "regulation of histidine biosynthesis" EXACT [GOC:krc] synonym: "regulation of histidine formation" EXACT [GOC:krc] synonym: "regulation of histidine synthesis" EXACT [GOC:krc] is_a: GO:0062012 ! regulation of small molecule metabolic process is_a: GO:2000282 ! regulation of amino acid biosynthetic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0000105 ! regulates L-histidine biosynthetic process relationship: RO:0002211 GO:0000105 ! regulates L-histidine biosynthetic process property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/17537" xsd:anyURI property_value: RO:0002161 NCBITaxon:7742 creation_date: 2019-06-27T20:55:42Z [Term] id: GO:0120214 name: negative regulation of histidine biosynthetic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of histidine biosynthetic process." [GOC:krc] synonym: "down regulation of histidine anabolism" EXACT [GOC:krc] synonym: "down regulation of histidine biosynthesis" EXACT [GOC:krc] synonym: "down regulation of histidine biosynthetic process" EXACT [GOC:krc] synonym: "down regulation of histidine formation" EXACT [GOC:krc] synonym: "down regulation of histidine synthesis" EXACT [GOC:krc] synonym: "down-regulation of histidine anabolism" EXACT [GOC:krc] synonym: "down-regulation of histidine biosynthesis" EXACT [GOC:krc] synonym: "down-regulation of histidine biosynthetic process" EXACT [GOC:krc] synonym: "down-regulation of histidine formation" EXACT [GOC:krc] synonym: "down-regulation of histidine synthesis" EXACT [GOC:krc] synonym: "downregulation of histidine anabolism" EXACT [GOC:krc] synonym: "downregulation of histidine biosynthesis" EXACT [GOC:krc] synonym: "downregulation of histidine biosynthetic process" EXACT [GOC:krc] synonym: "downregulation of histidine formation" EXACT [GOC:krc] synonym: "downregulation of histidine synthesis" EXACT [GOC:krc] synonym: "inhibition of histidine anabolism" NARROW [GOC:krc] synonym: "inhibition of histidine biosynthesis" NARROW [GOC:krc] synonym: "inhibition of histidine biosynthetic process" NARROW [GOC:krc] synonym: "inhibition of histidine formation" NARROW [GOC:krc] synonym: "inhibition of histidine synthesis" NARROW [GOC:krc] synonym: "negative regulation of histidine anabolism" EXACT [GOC:krc] synonym: "negative regulation of histidine biosynthesis" EXACT [GOC:krc] synonym: "negative regulation of histidine formation" EXACT [GOC:krc] synonym: "negative regulation of histidine synthesis" EXACT [GOC:krc] is_a: GO:0062014 ! negative regulation of small molecule metabolic process is_a: GO:0120213 ! regulation of histidine biosynthetic process is_a: GO:2000283 ! negative regulation of amino acid biosynthetic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0000105 ! negatively regulates L-histidine biosynthetic process relationship: RO:0002212 GO:0000105 ! negatively regulates L-histidine biosynthetic process property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/17537" xsd:anyURI property_value: RO:0002161 NCBITaxon:7742 creation_date: 2019-06-27T20:56:35Z [Term] id: GO:0120215 name: positive regulation of histidine biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of histidine biosynthetic process." [GOC:krc] synonym: "activation of histidine anabolism" NARROW [GOC:krc] synonym: "activation of histidine biosynthesis" NARROW [GOC:krc] synonym: "activation of histidine biosynthetic process" NARROW [GOC:krc] synonym: "activation of histidine formation" NARROW [GOC:krc] synonym: "activation of histidine synthesis" NARROW [GOC:krc] synonym: "positive regulation of histidine anabolism" EXACT [GOC:krc] synonym: "positive regulation of histidine biosynthesis" EXACT [GOC:krc] synonym: "positive regulation of histidine formation" EXACT [GOC:krc] synonym: "positive regulation of histidine synthesis" EXACT [GOC:krc] synonym: "up regulation of histidine anabolism" EXACT [GOC:krc] synonym: "up regulation of histidine biosynthesis" EXACT [GOC:krc] synonym: "up regulation of histidine biosynthetic process" EXACT [GOC:krc] synonym: "up regulation of histidine formation" EXACT [GOC:krc] synonym: "up regulation of histidine synthesis" EXACT [GOC:krc] synonym: "up-regulation of histidine anabolism" EXACT [GOC:krc] synonym: "up-regulation of histidine biosynthesis" EXACT [GOC:krc] synonym: "up-regulation of histidine biosynthetic process" EXACT [GOC:krc] synonym: "up-regulation of histidine formation" EXACT [GOC:krc] synonym: "up-regulation of histidine synthesis" EXACT [GOC:krc] synonym: "upregulation of histidine anabolism" EXACT [GOC:krc] synonym: "upregulation of histidine biosynthesis" EXACT [GOC:krc] synonym: "upregulation of histidine biosynthetic process" EXACT [GOC:krc] synonym: "upregulation of histidine formation" EXACT [GOC:krc] synonym: "upregulation of histidine synthesis" EXACT [GOC:krc] is_a: GO:0062013 ! positive regulation of small molecule metabolic process is_a: GO:0120213 ! regulation of histidine biosynthetic process is_a: GO:2000284 ! positive regulation of amino acid biosynthetic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0000105 ! positively regulates L-histidine biosynthetic process relationship: RO:0002213 GO:0000105 ! positively regulates L-histidine biosynthetic process property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/17537" xsd:anyURI property_value: RO:0002161 NCBITaxon:7742 creation_date: 2019-06-27T20:57:28Z [Term] id: GO:0120222 name: regulation of blastocyst development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of blastocyst development." [GOC:krc, PMID:29593216] is_a: GO:0050793 ! regulation of developmental process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0001824 ! regulates blastocyst development relationship: RO:0002211 GO:0001824 ! regulates blastocyst development property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/18871" xsd:anyURI creation_date: 2020-02-17T19:59:20Z [Term] id: GO:0120223 name: larynx morphogenesis namespace: biological_process def: "The process in which the larynx is generated and organized. The larynx is a continuation of the pharynx that is involved in breathing, sound production, and protecting the trachea against food aspiration." [GOC:krc, PMID:28177282] synonym: "laryngeal morphogenesis" EXACT [GOC:krc, PMID:28177282] is_a: GO:0009887 ! animal organ morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0001737 ! results in morphogenesis of larynx relationship: BFO:0000050 GO:0120224 ! part of larynx development relationship: RO:0002298 UBERON:0001737 ! results in morphogenesis of larynx property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/18924" xsd:anyURI creation_date: 2020-02-22T01:42:04Z [Term] id: GO:0120224 name: larynx development namespace: biological_process def: "The biological process whose specific outcome is the progression of a larynx from an initial condition to its mature state. This process begins with the formation of the larynx and ends with the mature structure. A larynx is a continuation of the pharynx that is involved in breathing, sound production, and protecting the trachea against food aspiration." [GOC:krc, PMID:28177282] is_a: GO:0048513 ! animal organ development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0001737 ! results in development of larynx relationship: BFO:0000050 GO:0060541 ! part of respiratory system development relationship: RO:0002296 UBERON:0001737 ! results in development of larynx property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/18924" xsd:anyURI creation_date: 2020-02-24T17:13:10Z [Term] id: GO:0120229 name: protein localization to motile cilium namespace: biological_process def: "A process in which a protein is transported to, or maintained in, a location within a motile cilium." [GOC:krc, PMID:27486780] synonym: "protein localization to nonmotile primary cilium" RELATED [] is_a: GO:0061512 ! protein localization to cilium intersection_of: GO:0008104 ! intracellular protein localization intersection_of: RO:0002339 GO:0031514 ! has target end location motile cilium relationship: RO:0002339 GO:0031514 ! has target end location motile cilium property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/19588" xsd:anyURI property_value: RO:0002161 NCBITaxon:3176 property_value: RO:0002161 NCBITaxon:3378 property_value: RO:0002161 NCBITaxon:3398 property_value: RO:0002161 NCBITaxon:4890 property_value: RO:0002161 NCBITaxon:5782 creation_date: 2020-06-05T23:43:04Z [Term] id: GO:0120254 name: olefinic compound metabolic process namespace: biological_process def: "The chemical reactions and pathways involving an olefinic compound, any compound which contains a carbon-carbon double bond (aka C=C)." [GOC:krc] synonym: "alkene substituted compound metabolic process" EXACT [] synonym: "alkene substituted compound metabolism" EXACT [] is_a: BFO:0000003 is_a: GO:0008152 ! metabolic process intersection_of: GO:0008152 ! metabolic process intersection_of: RO:0004007 CHEBI:78840 ! has primary input or output relationship: RO:0004007 CHEBI:78840 ! has primary input or output property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/19936" xsd:anyURI creation_date: 2020-09-02T23:13:44Z [Term] id: GO:0120255 name: olefinic compound biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of an olefinic compound, any compound which contains a carbon-carbon double bond (aka C=C)." [GOC:krc] synonym: "alkene substituted compound anabolic process" EXACT [GOC:krc] synonym: "alkene substituted compound anabolism" EXACT [GOC:krc] synonym: "alkene substituted compound biosynthesis" EXACT [GOC:krc] synonym: "alkene substituted compound biosynthetic process" EXACT [GOC:krc] synonym: "alkene substituted compound synthesis" EXACT [GOC:krc] is_a: GO:0009058 ! biosynthetic process is_a: GO:0120254 ! olefinic compound metabolic process intersection_of: GO:0009058 ! biosynthetic process intersection_of: RO:0004008 CHEBI:78840 ! has primary output relationship: RO:0004008 CHEBI:78840 ! has primary output property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/19936" xsd:anyURI creation_date: 2020-09-02T23:30:20Z [Term] id: GO:0120256 name: olefinic compound catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of an olefinic compound, any compound which contains a carbon-carbon double bond (aka C=C)." [GOC:krc] synonym: "alkene substituted compound breakdown" EXACT [GOC:krc] synonym: "alkene substituted compound catabolic process" EXACT [GOC:krc] synonym: "alkene substituted compound catabolism" EXACT [GOC:krc] synonym: "alkene substituted compound degradation" EXACT [GOC:krc] is_a: GO:0009056 ! catabolic process is_a: GO:0120254 ! olefinic compound metabolic process intersection_of: GO:0009056 ! catabolic process intersection_of: RO:0004009 CHEBI:78840 ! has primary input relationship: RO:0004009 CHEBI:78840 ! has primary input property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/19936" xsd:anyURI creation_date: 2020-09-02T23:30:41Z [Term] id: GO:0120261 name: regulation of heterochromatin organization namespace: biological_process def: "Any process that modulates the frequency, rate, extent or location of heterochromatin organization." [GOC:krc] is_a: GO:1902275 ! regulation of chromatin organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0070828 ! regulates heterochromatin organization relationship: RO:0002211 GO:0070828 ! regulates heterochromatin organization property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/20020" xsd:anyURI creation_date: 2020-09-29T20:00:04Z [Term] id: GO:0120262 name: negative regulation of heterochromatin organization namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of heterochromatin organization." [GOC:krc] synonym: "down regulation of heterochromatin organization" EXACT [] synonym: "down-regulation of heterochromatin organization" EXACT [] synonym: "downregulation of heterochromatin organization" EXACT [] synonym: "inhibition of heterochromatin organization" NARROW [] is_a: GO:0120261 ! regulation of heterochromatin organization is_a: GO:1905268 ! negative regulation of chromatin organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0070828 ! negatively regulates heterochromatin organization relationship: RO:0002212 GO:0070828 ! negatively regulates heterochromatin organization property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/20020" xsd:anyURI creation_date: 2020-09-29T20:12:30Z [Term] id: GO:0120263 name: positive regulation of heterochromatin organization namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of heterochromatin organization." [GOC:krc] synonym: "activation of heterochromatin organization" NARROW [] synonym: "stimulation of heterochromatin organization" NARROW [] synonym: "up regulation of heterochromatin organization" EXACT [] synonym: "up-regulation of heterochromatin organization" EXACT [] synonym: "upregulation of heterochromatin organization" EXACT [] is_a: GO:0120261 ! regulation of heterochromatin organization is_a: GO:1905269 ! positive regulation of chromatin organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0070828 ! positively regulates heterochromatin organization relationship: RO:0002213 GO:0070828 ! positively regulates heterochromatin organization property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/20020" xsd:anyURI creation_date: 2020-09-29T20:19:19Z [Term] id: GO:0120275 name: cerebral blood circulation namespace: biological_process def: "The flow of blood through the network of arteries and veins supplying the cerebrum, enabling the transport of nutrients to the tissues and the removal of waste products." [GOC:krc, PMID:25397684] synonym: "cerebrum blood circulation" EXACT [] synonym: "telencephelon blood circulation" EXACT [] is_a: BFO:0000003 is_a: GO:0008015 ! blood circulation intersection_of: GO:0008015 ! blood circulation intersection_of: BFO:0000066 UBERON:0001893 ! occurs in telencephalon relationship: BFO:0000066 UBERON:0001893 ! occurs in telencephalon property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/20107" xsd:anyURI property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 creation_date: 2020-10-20T19:13:51Z [Term] id: GO:0120276 name: regulation of cerebral blood circulation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cerebral blood circulation." [GOC:krc, PMID:25397684] synonym: "regulation of cerebrum blood circulation" EXACT [] synonym: "regulation of telencephalon blood circulation" EXACT [] is_a: GO:1903522 ! regulation of blood circulation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0120275 ! regulates cerebral blood circulation relationship: RO:0002211 GO:0120275 ! regulates cerebral blood circulation property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/20107" xsd:anyURI property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 creation_date: 2020-10-21T06:52:22Z [Term] id: GO:0120277 name: positive regulation of cerebral blood circulation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cerebral blood circulation." [GOC:krc, PMID:25397684] synonym: "activation of cerebral blood circulation" NARROW [] synonym: "positive regulation of cerebrum blood circulation" EXACT [] synonym: "positive regulation of telencephalon blood circulation" EXACT [] synonym: "up regulation of cerebral blood circulation" EXACT [] synonym: "up-regulation of cerebral blood circulation" EXACT [] synonym: "upregulation of cerebral blood circulation" EXACT [] is_a: GO:0120276 ! regulation of cerebral blood circulation is_a: GO:1903524 ! positive regulation of blood circulation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0120275 ! positively regulates cerebral blood circulation relationship: RO:0002213 GO:0120275 ! positively regulates cerebral blood circulation property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/20107" xsd:anyURI property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 creation_date: 2020-10-21T06:55:42Z [Term] id: GO:0120278 name: negative regulation of cerebral blood circulation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of cerebral blood circulation." [GOC:krc, PMID:25397684] synonym: "down regulation of cerebral blood circulation" EXACT [] synonym: "down-regulation of cerebral blood circulation" EXACT [] synonym: "downregulation of cerebral blood circulation" EXACT [] synonym: "inhibition of cerebral blood circulation" NARROW [] synonym: "negative regulation of cerebrum blood circulation" EXACT [] synonym: "negative regulation of telencephalon blood circulation" EXACT [] is_a: GO:0120276 ! regulation of cerebral blood circulation is_a: GO:1903523 ! negative regulation of blood circulation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0120275 ! negatively regulates cerebral blood circulation relationship: RO:0002212 GO:0120275 ! negatively regulates cerebral blood circulation property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/20107" xsd:anyURI property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 creation_date: 2020-10-21T07:02:05Z [Term] id: GO:0120305 name: regulation of pigmentation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the deposition or modulates the distribution of coloring matter in an organism." [GOC:krc] is_a: GO:0050789 ! regulation of biological process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0043473 ! regulates pigmentation relationship: RO:0002211 GO:0043473 ! regulates pigmentation property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/20524" xsd:anyURI creation_date: 2021-02-09T19:37:35Z [Term] id: GO:0120308 name: axonemal outer doublet assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form an axonemal outer doublet, a part of an axoneme consisting of a doublet microtubule." [GOC:ach, GOC:krc, PMID:16278296] synonym: "axonemal outer doublet biogenesis" EXACT [] synonym: "axonemal outer doublet formation" EXACT [] synonym: "axonemal outer doublet morphogenesis" EXACT [] synonym: "axoneme outer doublet assembly" EXACT [] synonym: "outer doublet assembly" BROAD [] synonym: "outer-doublet microtubule assembly" BROAD [] is_a: GO:0022607 ! cellular component assembly intersection_of: GO:0009987 ! cellular process intersection_of: RO:0002588 GO:0097545 ! results in assembly of axonemal doublet microtubule relationship: BFO:0000050 GO:0035082 ! part of axoneme assembly relationship: RO:0002588 GO:0097545 ! results in assembly of axonemal doublet microtubule property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/21154" xsd:anyURI property_value: RO:0002161 NCBITaxon:3176 property_value: RO:0002161 NCBITaxon:3378 property_value: RO:0002161 NCBITaxon:3398 property_value: RO:0002161 NCBITaxon:4890 property_value: RO:0002161 NCBITaxon:5782 creation_date: 2021-03-23T16:28:18Z [Term] id: GO:0120316 name: sperm flagellum assembly namespace: biological_process def: "The assembly and organization of the sperm flagellum, the microtubule-based axoneme and associated structures that are part of a sperm flagellum (or cilium)." [GOC:krc, PMID:32791035] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0044458 ! motile cilium assembly intersection_of: GO:0044458 ! motile cilium assembly intersection_of: BFO:0000066 CL:0000019 ! occurs in sperm relationship: BFO:0000050 GO:0007286 ! part of spermatid development relationship: BFO:0000050 GO:0030317 ! part of flagellated sperm motility relationship: BFO:0000066 CL:0000019 ! occurs in sperm property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/21361" xsd:anyURI property_value: RO:0002161 NCBITaxon:3176 property_value: RO:0002161 NCBITaxon:3378 property_value: RO:0002161 NCBITaxon:3398 property_value: RO:0002161 NCBITaxon:4751 property_value: RO:0002161 NCBITaxon:5782 creation_date: 2021-04-29T01:27:27Z [Term] id: GO:0120327 name: telopode namespace: cellular_component def: "A telopode is a plasma membrane bounded cell projection that is present on a telocyte and is tens to hundreds of microns long. Telopodes form a labyrinthine system communicating through gap junctions." [GOC:krc, MESH:D000067617, PMID:20367664] is_a: GO:0120025 ! plasma membrane bounded cell projection property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/21973" xsd:anyURI creation_date: 2021-08-16T16:45:21Z [Term] id: GO:0120331 name: endothelial tube formation namespace: biological_process def: "The developmental process pertaining to the initial formation of an endothelial tube." [GOC:sl, PMID:23239824] is_a: GO:0072175 ! epithelial tube formation intersection_of: GO:0035148 ! tube formation intersection_of: RO:0002297 UBERON:0003915 ! results in formation of anatomical entity endothelial tube relationship: BFO:0000050 GO:0061154 ! part of endothelial tube morphogenesis relationship: RO:0002297 UBERON:0003915 ! results in formation of anatomical entity endothelial tube property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/22302" xsd:anyURI creation_date: 2022-05-25T16:17:59Z [Term] id: GO:0120543 name: macromolecular conformation isomerase activity namespace: molecular_function def: "Catalysis of a reaction that alters the macromolecular conformation of a molecule." [EC:5.6.-.-] xref: EC:5.6.-.- is_a: GO:0016853 ! isomerase activity property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/29690" xsd:anyURI creation_date: 2025-02-11T09:46:30Z [Term] id: GO:0120544 name: polypeptide conformation or assembly isomerase activity namespace: molecular_function def: "Catalysis of a reaction that alters the conformation or assembly of a polypeptide." [EC:5.6.1.-] xref: EC:5.6.1.- is_a: GO:0120543 ! macromolecular conformation isomerase activity property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/29690" xsd:anyURI creation_date: 2025-02-11T09:51:11Z [Term] id: GO:0140001 name: morula formation namespace: biological_process def: "The initial formation of a spherical embryonic mass of blastomeres formed before the blastula and resulting from cleavage of the fertilized ovum." [PMID:37935903, PMID:38386558, PMID:39361745] is_a: BFO:0000003 is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0000085 ! results in formation of anatomical entity morula relationship: RO:0002297 UBERON:0000085 ! results in formation of anatomical entity morula property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/29162" xsd:anyURI creation_date: 2024-11-12T09:29:56Z [Term] id: GO:0140013 name: meiotic nuclear division namespace: biological_process def: "One of the two nuclear divisions that occur as part of the meiotic cell cycle." [PMID:9334324] subset: goslim_generic synonym: "meiosis" EXACT [] is_a: GO:0000280 ! nuclear division is_a: GO:1903046 ! meiotic cell cycle process intersection_of: GO:0000280 ! nuclear division intersection_of: BFO:0000050 GO:0051321 ! part of meiotic cell cycle property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/19910" xsd:anyURI creation_date: 2017-03-23T09:40:00Z [Term] id: GO:0140014 name: mitotic nuclear division namespace: biological_process def: "A mitotic cell cycle process comprising the steps by which the nucleus of a eukaryotic cell divides; the process involves condensation of chromosomal DNA into a highly compacted form. Canonically, mitosis produces two daughter nuclei whose chromosome complement is identical to that of the mother cell." [ISBN:0198547684] subset: goslim_chembl subset: goslim_generic synonym: "mitosis" EXACT [] is_a: GO:0000280 ! nuclear division is_a: GO:1903047 ! mitotic cell cycle process intersection_of: GO:0000280 ! nuclear division intersection_of: BFO:0000050 GO:0000278 ! part of mitotic cell cycle property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/19910" xsd:anyURI creation_date: 2017-03-23T14:44:23Z [Term] id: GO:0140021 name: mitochondrial ADP transmembrane transport namespace: biological_process def: "The process in which ADP is transported across a mitochondrial membrane, into or out of the mitochondrion." [PMID:2541251] is_a: GO:0015866 ! ADP transport is_a: GO:0072530 ! purine-containing compound transmembrane transport is_a: GO:1901679 ! nucleotide transmembrane transport intersection_of: GO:0006810 ! transport intersection_of: RO:0002342 GO:0031966 ! results in transport across mitochondrial membrane intersection_of: RO:0004009 CHEBI:456216 ! has primary input relationship: RO:0002342 GO:0031966 ! results in transport across mitochondrial membrane creation_date: 2017-04-10T15:14:34Z [Term] id: GO:0140029 name: exocytic process namespace: biological_process def: "The cellular processes that contribute to exocytosis." [Wikipedia:Exocytosis] subset: gocheck_do_not_annotate is_a: GO:0009987 ! cellular process intersection_of: GO:0009987 ! cellular process intersection_of: BFO:0000050 GO:0006887 ! part of exocytosis relationship: BFO:0000050 GO:0006887 ! part of exocytosis creation_date: 2017-05-15T13:20:45Z [Term] id: GO:0140039 name: cell-cell adhesion in response to extracellular stimulus namespace: biological_process def: "The attachment of one cell to another cell via adhesion molecules as a result of an extracellular stimulus." [PMID:14996911] is_a: GO:0098609 ! cell-cell adhesion intersection_of: GO:0098609 ! cell-cell adhesion intersection_of: BFO:0000050 GO:0051716 ! part of cellular response to stimulus relationship: BFO:0000050 GO:0051716 ! part of cellular response to stimulus creation_date: 2017-05-24T11:37:30Z [Term] id: GO:0140053 name: mitochondrial gene expression namespace: biological_process def: "The process in which a mitochondrial gene's sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form." [PMID:27058308] subset: goslim_generic subset: goslim_pombe is_a: GO:0010467 ! gene expression intersection_of: GO:0010467 ! gene expression intersection_of: BFO:0000066 GO:0005739 ! occurs in mitochondrion relationship: BFO:0000066 GO:0005739 ! occurs in mitochondrion relationship: RO:0002162 NCBITaxon:2759 ! in taxon Eukaryota creation_date: 2017-06-26T10:57:45Z [Term] id: GO:0140056 name: organelle localization by membrane tethering namespace: biological_process def: "The process by which an organelle membrane interacts with another membrane via molecular tethers that physically bridge the two membranes and attach them to each other." [PMID:27875684] subset: goslim_pombe is_a: GO:0022406 ! membrane docking is_a: GO:0051640 ! organelle localization creation_date: 2017-06-27T09:58:51Z [Term] id: GO:0140075 name: regulation of lipoprotein transport namespace: biological_process def: "Any process that controls lipoprotein transport." [GOC:BHF, GOC:BHF_miRNA, GOC:RPH, PMID:26501192] is_a: GO:0051223 ! regulation of protein transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0042953 ! regulates lipoprotein transport relationship: RO:0002211 GO:0042953 ! regulates lipoprotein transport creation_date: 2017-07-21T15:35:47Z [Term] id: GO:0140076 name: negative regulation of lipoprotein transport namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of lipoprotein transport." [GOC:BHF, GOC:BHF_miRNA, GOC:RPH, PMID:26501192] is_a: GO:0051224 ! negative regulation of protein transport is_a: GO:0140075 ! regulation of lipoprotein transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0042953 ! negatively regulates lipoprotein transport relationship: RO:0002212 GO:0042953 ! negatively regulates lipoprotein transport creation_date: 2017-07-21T15:39:50Z [Term] id: GO:0140077 name: positive regulation of lipoprotein transport namespace: biological_process def: "Any process that activates or increases the rate or extent of lipoprotein transport." [GOC:BHF, GOC:BHF_miRNA, GOC:RPH, PMID:26501192] is_a: GO:0051222 ! positive regulation of protein transport is_a: GO:0140075 ! regulation of lipoprotein transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0042953 ! positively regulates lipoprotein transport relationship: RO:0002213 GO:0042953 ! positively regulates lipoprotein transport creation_date: 2017-07-21T15:41:54Z [Term] id: GO:0140096 name: catalytic activity, acting on a protein namespace: molecular_function def: "Catalytic activity that acts to modify a protein." [GOC:molecular_function_refactoring, GOC:pdt] subset: goslim_generic subset: goslim_prokaryote is_a: BFO:0000003 is_a: GO:0003824 ! catalytic activity intersection_of: GO:0003824 ! catalytic activity intersection_of: RO:0004009 PR:000000001 ! has primary input protein relationship: RO:0004009 PR:000000001 ! has primary input protein property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/14225" xsd:anyURI creation_date: 2017-09-14T10:32:59Z [Term] id: GO:0140097 name: catalytic activity, acting on DNA namespace: molecular_function def: "Catalytic activity that acts to modify DNA." [GOC:molecular_function_refactoring, GOC:pdt] subset: goslim_generic subset: goslim_prokaryote is_a: GO:0140640 ! catalytic activity, acting on a nucleic acid intersection_of: GO:0003824 ! catalytic activity intersection_of: RO:0004009 CHEBI:16991 ! has primary input relationship: RO:0004009 CHEBI:16991 ! has primary input property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/14225" xsd:anyURI creation_date: 2017-09-14T12:03:51Z [Term] id: GO:0140098 name: catalytic activity, acting on RNA namespace: molecular_function def: "Catalytic activity that acts to modify RNA." [GOC:molecular_function_refactoring, GOC:pdt] subset: goslim_generic subset: goslim_prokaryote is_a: GO:0140640 ! catalytic activity, acting on a nucleic acid intersection_of: GO:0003824 ! catalytic activity intersection_of: RO:0004009 CHEBI:33697 ! has primary input relationship: RO:0004009 CHEBI:33697 ! has primary input property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/14208" xsd:anyURI property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/14225" xsd:anyURI property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/21612" xsd:anyURI creation_date: 2017-09-14T12:05:21Z [Term] id: GO:0140101 name: catalytic activity, acting on a tRNA namespace: molecular_function def: "Catalytic activity that acts to modify a tRNA." [GOC:molecular_function_refactoring, GOC:pdt] comment: Note that this term excludes activities for which a charged tRNA acts as an amino acid donor. is_a: GO:0140098 ! catalytic activity, acting on RNA intersection_of: GO:0003824 ! catalytic activity intersection_of: RO:0004009 CHEBI:17843 ! has primary input relationship: RO:0004009 CHEBI:17843 ! has primary input property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/14225" xsd:anyURI property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/25516" xsd:anyURI creation_date: 2017-09-15T18:41:41Z [Term] id: GO:0140103 name: catalytic activity, acting on a glycoprotein namespace: molecular_function def: "Catalysis of a biochemical reaction in which one of the substrates is a glycoprotein." [GOC:molecular_function_refactoring, GOC:pdt] is_a: GO:0140096 ! catalytic activity, acting on a protein intersection_of: GO:0003824 ! catalytic activity intersection_of: RO:0004009 CHEBI:17089 ! has primary input relationship: RO:0004009 CHEBI:17089 ! has primary input property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/14225" xsd:anyURI creation_date: 2017-09-15T19:27:54Z [Term] id: GO:0140112 name: extracellular vesicle biogenesis namespace: biological_process def: "The assembly and secretion a set of components to form an extracellular vesicule, a membrane-bounded vesicle that is released into the extracellular region. Extracellular vesicles include exosomes, microvesicles and apoptotic bodies, based on the mechanism by which they are released from cells and differentiated based on their size and content." [PMID:28736435] synonym: "extracellular vesicle assembly" EXACT [] is_a: GO:0044085 ! cellular component biogenesis property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/14256" xsd:anyURI creation_date: 2017-10-23T11:53:42Z [Term] id: GO:0140115 name: export across plasma membrane namespace: biological_process def: "The directed movement of some substance from inside of a cell, across the plasma membrane and into the extracellular region." [GOC:pg] synonym: "efflux" BROAD [] is_a: GO:0055085 ! transmembrane transport is_a: GO:0140352 ! export from cell intersection_of: GO:0006810 ! transport intersection_of: RO:0002338 GO:0005829 ! has target start location cytosol intersection_of: RO:0002339 GO:0005576 ! has target end location extracellular region intersection_of: RO:0002342 GO:0005886 ! results in transport across plasma membrane relationship: RO:0002338 GO:0005829 ! has target start location cytosol relationship: RO:0002342 GO:0005886 ! results in transport across plasma membrane creation_date: 2017-10-24T14:38:16Z [Term] id: GO:0140131 name: positive regulation of lymphocyte chemotaxis namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of lymphocyte chemotaxis." [PMID:19255442] is_a: GO:0002690 ! positive regulation of leukocyte chemotaxis is_a: GO:1901623 ! regulation of lymphocyte chemotaxis is_a: GO:2000403 ! positive regulation of lymphocyte migration intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0048247 ! positively regulates lymphocyte chemotaxis relationship: RO:0002213 GO:0048247 ! positively regulates lymphocyte chemotaxis creation_date: 2017-11-02T10:26:40Z [Term] id: GO:0140139 name: solid phase of basement membrane namespace: cellular_component def: "The solid compartment of the basement membrane ECM, including a specific subset of basement membrane collagens and basement membrane glycoproteins like laminins or nidogens." [PMID:33972551] is_a: GO:0030312 ! external encapsulating structure relationship: BFO:0000050 GO:0005604 ! part of basement membrane property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/29504" xsd:anyURI creation_date: 2025-03-20T11:44:22Z [Term] id: GO:0140141 name: mitochondrial potassium ion transmembrane transport namespace: biological_process def: "The process in which a potassium ion is transported across a mitochondrial membrane, into or out of the mitochondrion." [GOC:vw, PMID:20197279] is_a: GO:0071805 ! potassium ion transmembrane transport intersection_of: GO:0006810 ! transport intersection_of: RO:0002342 GO:0031966 ! results in transport across mitochondrial membrane intersection_of: RO:0004009 CHEBI:29103 ! has primary input relationship: RO:0002342 GO:0031966 ! results in transport across mitochondrial membrane creation_date: 2017-11-24T13:26:42Z [Term] id: GO:0140143 name: collagenous component of basement membrane namespace: cellular_component def: "Collagenous component of basement membrane ECMs, including collagen IV and other types of collagen specifically expressed in basement membrane." [PMID:21123617, PMID:21421915, PMID:28040522, PMID:28324731, PMID:31387942, PMID:39223427] is_a: GO:0030312 ! external encapsulating structure relationship: BFO:0000050 GO:0140139 ! part of solid phase of basement membrane property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/29472" xsd:anyURI creation_date: 2025-03-20T11:47:59Z [Term] id: GO:0140146 name: calcium ion import into vacuole namespace: biological_process def: "The directed movement of calcium cations into the vacuole across the vacuolar membrane." [GOC:vw, PMID:8628289] is_a: GO:0034486 ! vacuolar transmembrane transport is_a: GO:0070588 ! calcium ion transmembrane transport intersection_of: GO:0006810 ! transport intersection_of: RO:0002338 GO:0005829 ! has target start location cytosol intersection_of: RO:0002339 GO:0005775 ! has target end location vacuolar lumen intersection_of: RO:0002342 GO:0005774 ! results in transport across vacuolar membrane intersection_of: RO:0004009 CHEBI:29108 ! has primary input relationship: RO:0002338 GO:0005829 ! has target start location cytosol relationship: RO:0002339 GO:0005775 ! has target end location vacuolar lumen relationship: RO:0002342 GO:0005774 ! results in transport across vacuolar membrane creation_date: 2017-12-13T15:15:29Z [Term] id: GO:0140151 name: solid phase of interstitial matrix namespace: cellular_component def: "The solid compartment of the interstitial matrix, including interstitial collagens such as fibrillar and fibril-associated collagens and non-collagenous glycoproteins like fibronectin and elastin." [PMID:3284468, PMID:34807416] is_a: GO:0030312 ! external encapsulating structure relationship: BFO:0000050 GO:0005614 ! part of interstitial matrix property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/29505" xsd:anyURI creation_date: 2025-03-20T11:44:22Z [Term] id: GO:0140152 name: collagenous component of interstitial matrix namespace: cellular_component def: "Main components of the interstitial matrix solid phase, including fibrillar and fibril-associated collagens." [PMID:12064927, PMID:17550969, PMID:21421911, PMID:28101870, PMID:39223427] is_a: GO:0030312 ! external encapsulating structure relationship: BFO:0000050 GO:0140151 ! part of solid phase of interstitial matrix property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/29473" xsd:anyURI creation_date: 2025-03-20T11:47:59Z [Term] id: GO:0140154 name: chicken-wire-like collagen network namespace: cellular_component def: "Network-forming collagens can either form a chicken-wire-like network or a hexagonal network. Collagen type IV forms a chicken-wire-like structure and is found in the basement membrane." [PMID:21421911, PMID:21421915, PMID:31387942] is_a: GO:0098645 ! collagen network relationship: BFO:0000050 GO:0140143 ! part of collagenous component of basement membrane property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/29401" xsd:anyURI property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/30149" xsd:anyURI creation_date: 2025-03-26T06:42:53Z [Term] id: GO:0140157 name: ammonium import across plasma membrane namespace: biological_process def: "The directed movement of an ammonium ion from outside of a cell, across the plasma membrane and into the cytosol." [GOC:vw, PMID:16999738] is_a: GO:0072488 ! ammonium transmembrane transport is_a: GO:0098659 ! inorganic cation import across plasma membrane intersection_of: GO:0006810 ! transport intersection_of: RO:0002338 GO:0005576 ! has target start location extracellular region intersection_of: RO:0002339 GO:0005829 ! has target end location cytosol intersection_of: RO:0002342 GO:0005886 ! results in transport across plasma membrane intersection_of: RO:0004009 CHEBI:28938 ! has primary input creation_date: 2018-01-26T12:39:56Z [Term] id: GO:0140227 name: serotonin-gated cation-selective signaling pathway namespace: biological_process def: "The series of molecular signals initiated by serotonin binding to a seratonin receptor on the surface of the target cell, followed by the movement of ions through a channel in the receptor complex. Ends with regulation of a downstream cellular process, e.g. transcription." [GOC:bhm, PMID:25392484, PMID:27764665] synonym: "5-HT-gated cation-selective signaling pathway" EXACT [] synonym: "5-HT-gated cation-selective signalling pathway" EXACT [] synonym: "5-hydroxytryptamine-gated cation-selective signaling pathway" EXACT [] synonym: "5-hydroxytryptamine-gated cation-selective signalling pathway" EXACT [] synonym: "serotonin-gated cation-selective signalling pathway" EXACT [] is_a: GO:0007210 ! serotonin receptor signaling pathway is_a: GO:1990806 ! ligand-gated ion channel signaling pathway intersection_of: GO:0007165 ! signal transduction intersection_of: BFO:0000051 GO:0022850 ! has part serotonin-gated monoatomic cation channel activity intersection_of: RO:0002224 GO:0099589 ! starts with serotonin receptor activity relationship: BFO:0000051 GO:0022850 ! has part serotonin-gated monoatomic cation channel activity creation_date: 2018-06-02T13:34:51Z [Term] id: GO:0140231 name: anterograde axonal transport of neurotransmitter receptor complex namespace: biological_process def: "The directed movement of a neurotransmitter receptor complex along microtubules from the cell body toward the cell periphery in nerve cell axons." [PMID:28680963] subset: goslim_synapse is_a: GO:0097120 ! receptor localization to synapse is_a: GO:0099637 ! neurotransmitter receptor transport is_a: GO:0099641 ! anterograde axonal protein transport intersection_of: GO:0006810 ! transport intersection_of: BFO:0000066 GO:1904115 ! occurs in axon cytoplasm intersection_of: RO:0002339 GO:0098793 ! has target end location presynapse intersection_of: RO:0002341 GO:0005874 ! results in transport along microtubule intersection_of: RO:0004009 GO:0098878 ! has primary input neurotransmitter receptor complex creation_date: 2018-07-09T09:41:37Z [Term] id: GO:0140236 name: translation at presynapse namespace: biological_process def: "Translation that occurs at the presynapse." [PMID:27321671] comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. subset: goslim_synapse is_a: GO:0140241 ! translation at synapse intersection_of: GO:0006412 ! translation intersection_of: BFO:0000066 GO:0098793 ! occurs in presynapse relationship: BFO:0000066 GO:0098793 ! occurs in presynapse property_value: IAO:0000233 "https://github.com/geneontology/synapse/issues/216" xsd:anyURI creation_date: 2018-07-13T13:00:33Z [Term] id: GO:0140237 name: translation at presynapse, modulating chemical synaptic transmission namespace: biological_process def: "Translation that occurs at the presynapse, and that modulates chemical synaptic transmission." [PMID:27321671] comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. subset: goslim_synapse is_a: GO:0140236 ! translation at presynapse intersection_of: GO:0006412 ! translation intersection_of: BFO:0000066 GO:0098793 ! occurs in presynapse intersection_of: RO:0002211 GO:0007268 ! regulates chemical synaptic transmission relationship: RO:0002211 GO:0007268 ! regulates chemical synaptic transmission property_value: IAO:0000233 "https://github.com/geneontology/synapse/issues/216" xsd:anyURI creation_date: 2018-07-13T13:07:23Z [Term] id: GO:0140238 name: presynaptic endocytosis namespace: biological_process def: "A vesicle-mediated transport process in which the presynapse take up external materials or membrane constituents by the invagination of a small region of the plasma membrane to form a new membrane-bounded vesicle." [PMID:24719103] comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. subset: goslim_synapse is_a: GO:0006897 ! endocytosis is_a: GO:0051649 ! establishment of localization in cell is_a: GO:0099003 ! vesicle-mediated transport in synapse intersection_of: GO:0006897 ! endocytosis intersection_of: BFO:0000066 GO:0098793 ! occurs in presynapse relationship: BFO:0000066 GO:0098793 ! occurs in presynapse property_value: IAO:0000233 "https://github.com/geneontology/synapse/issues/230" xsd:anyURI creation_date: 2018-07-15T07:33:55Z [Term] id: GO:0140239 name: postsynaptic endocytosis namespace: biological_process def: "A vesicle-mediated transport process in which the postsynapse take up external materials or membrane constituents by the invagination of a small region of the plasma membrane to form a new membrane-bounded vesicle." [PMID:12839988] comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. subset: goslim_synapse is_a: GO:0006897 ! endocytosis is_a: GO:0051649 ! establishment of localization in cell is_a: GO:0099003 ! vesicle-mediated transport in synapse intersection_of: GO:0006897 ! endocytosis intersection_of: BFO:0000066 GO:0098794 ! occurs in postsynapse relationship: BFO:0000066 GO:0098794 ! occurs in postsynapse property_value: IAO:0000233 "https://github.com/geneontology/synapse/issues/230" xsd:anyURI creation_date: 2018-07-15T07:38:27Z [Term] id: GO:0140241 name: translation at synapse namespace: biological_process def: "Translation that occurs at the synapse." [PMID:23083742] comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. subset: goslim_synapse is_a: GO:0006412 ! translation intersection_of: GO:0006412 ! translation intersection_of: BFO:0000066 GO:0045202 ! occurs in synapse relationship: BFO:0000066 GO:0045202 ! occurs in synapse relationship: RO:0002162 NCBITaxon:33208 ! in taxon Metazoa property_value: IAO:0000233 "https://github.com/geneontology/synapse/issues/210" xsd:anyURI creation_date: 2018-07-15T09:23:12Z [Term] id: GO:0140242 name: translation at postsynapse namespace: biological_process def: "Translation that occurs at the postsynapse." [PMID:20427644] comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. subset: goslim_synapse is_a: GO:0140241 ! translation at synapse intersection_of: GO:0006412 ! translation intersection_of: BFO:0000066 GO:0098794 ! occurs in postsynapse relationship: BFO:0000066 GO:0098794 ! occurs in postsynapse property_value: IAO:0000233 "https://github.com/geneontology/synapse/issues/210" xsd:anyURI creation_date: 2018-07-15T09:26:27Z [Term] id: GO:0140243 name: regulation of translation at synapse namespace: biological_process def: "Any process that regulates translation occurring at the synapse." [PMID:20427644] comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. subset: goslim_synapse is_a: GO:0006417 ! regulation of translation intersection_of: GO:0065007 ! biological regulation intersection_of: BFO:0000066 GO:0045202 ! occurs in synapse intersection_of: RO:0002211 GO:0006412 ! regulates translation relationship: BFO:0000066 GO:0045202 ! occurs in synapse relationship: RO:0002162 NCBITaxon:33208 ! in taxon Metazoa property_value: IAO:0000233 "https://github.com/geneontology/synapse/issues/210" xsd:anyURI creation_date: 2018-07-15T09:38:26Z [Term] id: GO:0140244 name: regulation of translation at presynapse namespace: biological_process def: "Any process that regulates translation occurring at the presynapse." [PMID:20427644] comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. subset: goslim_synapse is_a: GO:0140243 ! regulation of translation at synapse intersection_of: GO:0065007 ! biological regulation intersection_of: BFO:0000066 GO:0098793 ! occurs in presynapse intersection_of: RO:0002211 GO:0006412 ! regulates translation relationship: BFO:0000066 GO:0098793 ! occurs in presynapse property_value: IAO:0000233 "https://github.com/geneontology/synapse/issues/210" xsd:anyURI creation_date: 2018-07-15T09:38:33Z [Term] id: GO:0140245 name: regulation of translation at postsynapse namespace: biological_process def: "Any process that regulates translation occurring at the postsynapse." [PMID:20427644] comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. subset: goslim_synapse is_a: GO:0140243 ! regulation of translation at synapse intersection_of: GO:0065007 ! biological regulation intersection_of: BFO:0000066 GO:0098794 ! occurs in postsynapse intersection_of: RO:0002211 GO:0006412 ! regulates translation relationship: BFO:0000066 GO:0098794 ! occurs in postsynapse property_value: IAO:0000233 "https://github.com/geneontology/synapse/issues/210" xsd:anyURI creation_date: 2018-07-15T09:38:54Z [Term] id: GO:0140246 name: protein catabolic process at synapse namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of a protein at a synapse." [PMID:17062563] comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. subset: goslim_synapse is_a: GO:0030163 ! protein catabolic process intersection_of: GO:0009056 ! catabolic process intersection_of: BFO:0000066 GO:0045202 ! occurs in synapse intersection_of: RO:0004009 CHEBI:36080 ! has primary input relationship: BFO:0000066 GO:0045202 ! occurs in synapse relationship: RO:0002162 NCBITaxon:33208 ! in taxon Metazoa relationship: RO:0004009 CHEBI:36080 ! has primary input property_value: IAO:0000233 "https://github.com/geneontology/synapse/issues/210" xsd:anyURI creation_date: 2018-07-15T10:12:51Z [Term] id: GO:0140247 name: protein catabolic process at presynapse namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of a protein at a presynapse." [PMID:27764673] comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. subset: goslim_synapse is_a: GO:0140246 ! protein catabolic process at synapse intersection_of: GO:0009056 ! catabolic process intersection_of: BFO:0000066 GO:0098793 ! occurs in presynapse intersection_of: RO:0004009 CHEBI:36080 ! has primary input relationship: BFO:0000066 GO:0098793 ! occurs in presynapse property_value: IAO:0000233 "https://github.com/geneontology/synapse/issues/204" xsd:anyURI creation_date: 2018-07-15T10:23:49Z [Term] id: GO:0140249 name: protein catabolic process at postsynapse namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of a protein at a postsynapse." [PMID:17062563] comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. subset: goslim_synapse is_a: GO:0140246 ! protein catabolic process at synapse intersection_of: GO:0009056 ! catabolic process intersection_of: BFO:0000066 GO:0098794 ! occurs in postsynapse intersection_of: RO:0004009 CHEBI:36080 ! has primary input relationship: BFO:0000066 GO:0098794 ! occurs in postsynapse property_value: IAO:0000233 "https://github.com/geneontology/synapse/issues/204" xsd:anyURI creation_date: 2018-07-15T10:25:04Z [Term] id: GO:0140250 name: regulation protein catabolic process at synapse namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein at the synapse." [PMID:23083742] comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. subset: goslim_synapse is_a: GO:0009894 ! regulation of catabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: BFO:0000066 GO:0045202 ! occurs in synapse intersection_of: RO:0002211 GO:0009056 ! regulates catabolic process intersection_of: RO:0004009 CHEBI:36080 ! has primary input relationship: BFO:0000066 GO:0045202 ! occurs in synapse relationship: RO:0002162 NCBITaxon:33208 ! in taxon Metazoa relationship: RO:0004009 CHEBI:36080 ! has primary input property_value: IAO:0000233 "https://github.com/geneontology/synapse/issues/204" xsd:anyURI creation_date: 2018-07-15T10:34:56Z [Term] id: GO:0140251 name: regulation protein catabolic process at presynapse namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein at the presynapse." [PMID:27764673] comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. subset: goslim_synapse is_a: GO:0140250 ! regulation protein catabolic process at synapse intersection_of: GO:0065007 ! biological regulation intersection_of: BFO:0000066 GO:0098793 ! occurs in presynapse intersection_of: RO:0002211 GO:0009056 ! regulates catabolic process intersection_of: RO:0004009 CHEBI:36080 ! has primary input relationship: BFO:0000066 GO:0098793 ! occurs in presynapse property_value: IAO:0000233 "https://github.com/geneontology/synapse/issues/204" xsd:anyURI creation_date: 2018-07-15T10:35:39Z [Term] id: GO:0140252 name: regulation protein catabolic process at postsynapse namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein at the postsynapse." [PMID:17062563] comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. subset: goslim_synapse is_a: GO:0140250 ! regulation protein catabolic process at synapse intersection_of: GO:0065007 ! biological regulation intersection_of: BFO:0000066 GO:0098794 ! occurs in postsynapse intersection_of: RO:0002211 GO:0009056 ! regulates catabolic process intersection_of: RO:0004009 CHEBI:36080 ! has primary input relationship: BFO:0000066 GO:0098794 ! occurs in postsynapse property_value: IAO:0000233 "https://github.com/geneontology/synapse/issues/204" xsd:anyURI creation_date: 2018-07-15T10:35:56Z [Term] id: GO:0140253 name: cell-cell fusion namespace: biological_process def: "A cellular process in which two or more cells combine together, their plasma membrane fusing, producing a single cell. In some cases, nuclei fuse, producing a polyploid cell, while in other cases, nuclei remain separate, producing a syncytium." [Wikipedia:Cell_fusion] synonym: "cell cell fusion" EXACT [] synonym: "cell fusion" BROAD [] is_a: BFO:0000003 is_a: GO:0009987 ! cellular process relationship: BFO:0000051 GO:0045026 ! has part plasma membrane fusion property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/15939" xsd:anyURI creation_date: 2018-08-13T18:38:18Z [Term] id: GO:0140271 name: hexose import across plasma membrane namespace: biological_process def: "The directed movement of hexose from outside of a cell, across the plasma membrane and into the cytosol." [PMID:10735857] is_a: GO:0008645 ! hexose transmembrane transport is_a: GO:0098704 ! carbohydrate import across plasma membrane intersection_of: GO:0006810 ! transport intersection_of: RO:0002338 GO:0005576 ! has target start location extracellular region intersection_of: RO:0002339 GO:0005829 ! has target end location cytosol intersection_of: RO:0002342 GO:0005886 ! results in transport across plasma membrane intersection_of: RO:0004009 CHEBI:18133 ! has primary input creation_date: 2018-10-01T08:49:49Z [Term] id: GO:0140297 name: DNA-binding transcription factor binding namespace: molecular_function def: "Binding to a DNA-binding transcription factor, a protein that interacts with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription." [GOC:txnOH-2018] synonym: "activating transcription factor binding" RELATED [] synonym: "repressing transcription factor binding" RELATED [] synonym: "transcription activator binding" RELATED [] is_a: GO:0008134 ! transcription factor binding property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/19354" xsd:anyURI creation_date: 2018-11-28T12:48:20Z [Term] id: GO:0140318 name: protein transporter activity namespace: molecular_function def: "Directly binding to a specific protein and delivering it to a specific cellular location." [PMID:18706423] comment: Examples of protein carriers include the soluble TIM chaperone complexes of S. cerevisiae Tim9-Tim10 and Tim8-Tim13, that provide a shuttle system between TOM and the membrane insertases TIM22 and SAM and, thus, ensure that precursors are kept in a translocation-competent conformation. synonym: "protein carrier activity" RELATED [] synonym: "protein transport chaperone" RELATED [] xref: Reactome:R-HSA-2248891 "M6PR transports activated ARSA to the lysosome" xref: Reactome:R-HSA-9662747 "iRHOM2 transports ADAM17 from ER to the Golgi-network" xref: Reactome:R-HSA-9662818 "iRHOM2 transports ADAM17:Zn2+ from Golgi to the plasma membrane" is_a: BFO:0000003 is_a: GO:0005215 ! transporter activity intersection_of: GO:0005215 ! transporter activity intersection_of: RO:0004009 PR:000000001 ! has primary input protein relationship: RO:0004009 PR:000000001 ! has primary input protein property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/17073" xsd:anyURI creation_date: 2019-04-01T10:41:38Z [Term] id: GO:0140352 name: export from cell namespace: biological_process def: "The directed movement of some substance from a cell, into the extracellular region. This may occur via transport across the plasma membrane or via exocytosis." [GOC:pg] synonym: "efflux" BROAD [] is_a: GO:0006810 ! transport is_a: GO:0009987 ! cellular process intersection_of: GO:0006810 ! transport intersection_of: RO:0002338 GO:0005622 ! has target start location intracellular anatomical structure intersection_of: RO:0002339 GO:0005576 ! has target end location extracellular region relationship: RO:0002338 GO:0005622 ! has target start location intracellular anatomical structure relationship: RO:0002339 GO:0005576 ! has target end location extracellular region creation_date: 2019-05-22T11:20:45Z [Term] id: GO:0140353 name: lipid export from cell namespace: biological_process def: "The directed movement of a lipid from a cell, into the extracellular region." [GOC:pg] synonym: "lipid efflux" BROAD [] is_a: GO:0006869 ! lipid transport is_a: GO:0140352 ! export from cell intersection_of: GO:0006810 ! transport intersection_of: RO:0002338 GO:0005622 ! has target start location intracellular anatomical structure intersection_of: RO:0002339 GO:0005576 ! has target end location extracellular region intersection_of: RO:0004009 CHEBI:18059 ! has primary input creation_date: 2019-05-22T11:33:07Z [Term] id: GO:0140354 name: lipid import into cell namespace: biological_process def: "The directed movement of a lipid from outside of a cell into a cell. This may occur via transport across the plasma membrane or via endocytosis." [GOC:pg] synonym: "lipid uptake" BROAD [] is_a: GO:0006869 ! lipid transport intersection_of: GO:0006810 ! transport intersection_of: RO:0002338 GO:0005576 ! has target start location extracellular region intersection_of: RO:0002339 GO:0005622 ! has target end location intracellular anatomical structure intersection_of: RO:0004009 CHEBI:18059 ! has primary input relationship: RO:0002338 GO:0005576 ! has target start location extracellular region relationship: RO:0002339 GO:0005622 ! has target end location intracellular anatomical structure creation_date: 2019-05-22T11:38:15Z [Term] id: GO:0140375 name: immune receptor activity namespace: molecular_function def: "Receiving a signal and transmitting it in a cell to initiate an immune response." [PMID:31415752, Wikipedia:Immune_receptor] is_a: GO:0038023 ! signaling receptor activity creation_date: 2019-10-18T14:11:15Z [Term] id: GO:0140448 name: signaling receptor ligand precursor processing namespace: biological_process def: "The cleavage of a peptide bond in a precursor form of a signaling receptor ligand, resulting in the mature (active) form of the ligand." [PMID:29247995] synonym: "ligand maturation" NARROW [GOC:bf] synonym: "signal maturation" RELATED [] is_a: GO:0016485 ! protein processing property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/19216" xsd:anyURI creation_date: 2020-04-03T13:30:04Z [Term] id: GO:0140513 name: nuclear protein-containing complex namespace: cellular_component def: "A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together in the nucleus." [GOC:pg] subset: gocheck_do_not_annotate synonym: "nuclear complex" EXACT [] is_a: BFO:0000004 is_a: GO:0032991 ! protein-containing complex intersection_of: GO:0032991 ! protein-containing complex intersection_of: BFO:0000050 GO:0005634 ! part of nucleus relationship: BFO:0000050 GO:0005634 ! part of nucleus creation_date: 2020-09-09T05:12:38Z [Term] id: GO:0140546 name: defense response to symbiont namespace: biological_process def: "Reactions triggered in response to the presence of a symbiont that act to protect or prevent damage to the host." [GOC:pg] is_a: GO:0098542 ! defense response to other organism property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/20261" xsd:anyURI property_value: RO:0002161 NCBITaxon:4895 creation_date: 2020-11-11T17:19:06Z [Term] id: GO:0140572 name: vacuole fission namespace: biological_process def: "The division of a vacuole within a cell to form two or more separate vacuoles." [PMID:19643199] is_a: GO:0048285 ! organelle fission intersection_of: GO:0048285 ! organelle fission intersection_of: results_in_fission_of GO:0005773 ! vacuole relationship: results_in_fission_of GO:0005773 ! vacuole property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/20639" xsd:anyURI creation_date: 2021-01-04T10:17:58Z [Term] id: GO:0140640 name: catalytic activity, acting on a nucleic acid namespace: molecular_function def: "Catalytic activity that acts to modify a nucleic acid." [GOC:pg] is_a: BFO:0000003 is_a: GO:0003824 ! catalytic activity intersection_of: GO:0003824 ! catalytic activity intersection_of: RO:0004009 CHEBI:33696 ! has primary input relationship: RO:0004009 CHEBI:33696 ! has primary input property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/21402" xsd:anyURI creation_date: 2021-05-11T06:31:07Z [Term] id: GO:0140650 name: radial glia-guided pyramidal neuron migration namespace: biological_process def: "The radial migration of a pyramidal neuron along radial glial cells." [PMID:3760547] synonym: "radial glia-dependent neuronal migration" EXACT [] is_a: GO:0001764 ! neuron migration intersection_of: GO:0016477 ! cell migration intersection_of: RO:0002565 CL:0000598 ! results in movement of pyramidal neuron relationship: RO:0002565 CL:0000598 ! results in movement of pyramidal neuron property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/21476" xsd:anyURI creation_date: 2021-05-25T12:48:12Z [Term] id: GO:0140657 name: ATP-dependent activity namespace: molecular_function def: "A molecular function characterized by the coupling of ATP hydrolysis to other steps of a reaction mechanism to make the reaction energetically favorable, for example to catalyze a reaction or drive transport against a concentration gradient." [PMID:24878343, PMID:25750732, PMID:32933017, PMID:33818025, PMID:33873056, PMID:33988324] comment: Note that this term represents a grouping class that includes all proteins that use ATP hydrolysis to drive a reaction; it is not meant to capture the ATP hydrolysis reaction itself. To annotate ATP hydrolysis, please use 'ATP hydrolysis activity ; GO:0016887'. subset: gocheck_do_not_annotate subset: goslim_chembl subset: goslim_drosophila subset: goslim_generic subset: goslim_prokaryote subset: goslim_yeast synonym: "ATP hydrolysis-dependent activity" EXACT [] synonym: "ATPase activity" EXACT [] synonym: "ATPase activity, coupled" EXACT [] synonym: "ATPase-dependent activity" EXACT [] is_a: BFO:0000003 is_a: GO:0003674 ! molecular_function intersection_of: GO:0003674 ! molecular_function intersection_of: BFO:0000051 GO:0016887 ! has part ATP hydrolysis activity relationship: BFO:0000051 GO:0016887 ! has part ATP hydrolysis activity property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/21612" xsd:anyURI property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/22371" xsd:anyURI creation_date: 2021-06-15T07:35:06Z [Term] id: GO:0140667 name: regulation of oxytocin production namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of production of oxytocin." [PMID:25096581] is_a: GO:0010468 ! regulation of gene expression intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0036162 ! regulates oxytocin production relationship: RO:0002211 GO:0036162 ! regulates oxytocin production property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/21535" xsd:anyURI creation_date: 2021-06-24T11:28:07Z [Term] id: GO:0140668 name: positive regulation of oxytocin production namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of production of oxytocin." [PMID:25096581] is_a: GO:0010628 ! positive regulation of gene expression is_a: GO:0140667 ! regulation of oxytocin production intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0036162 ! positively regulates oxytocin production relationship: RO:0002213 GO:0036162 ! positively regulates oxytocin production property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/21535" xsd:anyURI creation_date: 2021-06-24T11:31:26Z [Term] id: GO:0140669 name: negative regulation of oxytocin production namespace: biological_process def: "Any process that stops, prevents, or reduces the rate of production of oxytocin." [PMID:25096581] is_a: GO:0010629 ! negative regulation of gene expression is_a: GO:0140667 ! regulation of oxytocin production intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0036162 ! negatively regulates oxytocin production relationship: RO:0002212 GO:0036162 ! negatively regulates oxytocin production property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/21535" xsd:anyURI creation_date: 2021-06-24T11:31:45Z [Term] id: GO:0140694 name: membraneless organelle assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form a non-membrane-bounded organelle." [PMID:28225081] synonym: "non-membrane-bounded organelle assembly" EXACT [] synonym: "non-membrane-bounded organelle formation" EXACT [] synonym: "non-membrane-enclosed organelle assembly" EXACT [] synonym: "non-membrane-enclosed organelle formation" EXACT [] is_a: GO:0070925 ! organelle assembly intersection_of: GO:0022607 ! cellular component assembly intersection_of: RO:0002588 GO:0043228 ! results in assembly of membraneless organelle relationship: RO:0002588 GO:0043228 ! results in assembly of membraneless organelle property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/21939" xsd:anyURI property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/29106" xsd:anyURI creation_date: 2021-08-09T15:30:06Z [Term] id: GO:0140734 name: ammonium excretion namespace: biological_process def: "The elimination of ammonium ions from an excretory cell." [PMID:25740900] synonym: "ammonia excretion" RELATED [] is_a: BFO:0000003 is_a: GO:0007588 ! excretion intersection_of: GO:0007588 ! excretion intersection_of: RO:0004009 CHEBI:28938 ! has primary input relationship: RO:0004009 CHEBI:28938 ! has primary input property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/22368" xsd:anyURI property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 creation_date: 2021-11-24T17:55:51Z [Term] id: GO:0140820 name: cytosol to Golgi apparatus transport namespace: biological_process def: "The directed movement of substances from the cytosol into the Golgi apparatus of a cell." [PMID:28373556] is_a: GO:0055085 ! transmembrane transport intersection_of: GO:0055085 ! transmembrane transport intersection_of: RO:0002338 GO:0005829 ! has target start location cytosol intersection_of: RO:0002339 GO:0005794 ! has target end location Golgi apparatus intersection_of: RO:0002342 GO:0016020 ! results in transport across membrane relationship: RO:0002338 GO:0005829 ! has target start location cytosol relationship: RO:0002339 GO:0005794 ! has target end location Golgi apparatus property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/21524" xsd:anyURI creation_date: 2022-05-16T06:59:22Z [Term] id: GO:0140899 name: plastid gene expression namespace: biological_process def: "The process in which a plastid gene's sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form." [PMID:28377785] is_a: GO:0010467 ! gene expression intersection_of: GO:0010467 ! gene expression intersection_of: BFO:0000066 GO:0009536 ! occurs in plastid relationship: BFO:0000066 GO:0009536 ! occurs in plastid property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/23083" xsd:anyURI creation_date: 2022-08-17T10:34:35Z [Term] id: GO:0140961 name: cellular detoxification of metal ion namespace: biological_process def: "Any process carried out at the cellular level that reduces or removes the toxicity of a metal ion." [PMID:26729300, PMID:33046888, PMID:34442707] synonym: "cellular detoxification of metal cation" EXACT [] is_a: GO:0061687 ! detoxification of inorganic compound is_a: GO:1990748 ! cellular detoxification intersection_of: GO:1990748 ! cellular detoxification intersection_of: RO:0004009 CHEBI:25213 ! has primary input relationship: RO:0004009 CHEBI:25213 ! has primary input creation_date: 2022-12-07T15:35:18Z [Term] id: GO:0140962 name: multicellular organismal-level chemical homeostasis namespace: biological_process def: "A homeostatic process involved in the maintenance of a steady state level of a chemical within extracellular body fluids, such as blood, xylem or phloem, of a multicellular organism. This is distinct from maintenance of cellular homeostasis, which occurs within a cell." [GOC:curators] synonym: "multicellular organism level chemical homeostasis" EXACT [] synonym: "organismal level chemical homeostasis" EXACT [] is_a: GO:0048871 ! multicellular organismal-level homeostasis is_a: GO:0048878 ! chemical homeostasis intersection_of: GO:0048871 ! multicellular organismal-level homeostasis intersection_of: RO:0002332 CHEBI:24431 ! regulates levels of property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/24554" xsd:anyURI property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 creation_date: 2022-12-12T09:11:06Z [Term] id: GO:0140979 name: intracellular nucleotide homeostasis namespace: biological_process def: "A homeostatic process involved in the maintenance of a steady state level of nucleotides within a cell." [PMID:23416111, PMID:34880500] is_a: GO:0055082 ! intracellular chemical homeostasis intersection_of: GO:0019725 ! cellular homeostasis intersection_of: RO:0002332 CHEBI:36976 ! regulates levels of relationship: RO:0002332 CHEBI:36976 ! regulates levels of property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/24665" xsd:anyURI creation_date: 2023-01-10T14:13:19Z [Term] id: GO:0141067 name: intracellular nitrogen homeostasis namespace: biological_process def: "A homeostatic process involved in the maintenance of a steady state level of nitrogen within a cell." [GOC:tb] synonym: "cellular nitrogen homeostasis" EXACT [] synonym: "nitrogen homeostasis" EXACT [] is_a: GO:0055082 ! intracellular chemical homeostasis intersection_of: GO:0019725 ! cellular homeostasis intersection_of: RO:0002332 CHEBI:17997 ! regulates levels of relationship: RO:0002332 CHEBI:17997 ! regulates levels of property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/25558" xsd:anyURI creation_date: 2023-06-15T08:56:16Z [Term] id: GO:0141124 name: intracellular signaling cassette namespace: biological_process def: "An intracellular signaling module that is part of larger signaling pathways that can be initiated either intracellularly or by cell surface receptors. Intracellular signaling cassettes are discrete signaling units that are often shared by multiple signaling pathways." [GOC:ha, GOC:pg] synonym: "intracellular signaling cascade" EXACT [] synonym: "intracellular signaling module" EXACT [] is_a: GO:0035556 ! intracellular signal transduction property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/26557" xsd:anyURI creation_date: 2023-12-04T14:13:20Z [Term] id: GO:0141187 name: nucleic acid biosynthetic process namespace: biological_process def: "The biosynthetic process resulting in the formation of a nucleic acid." [GOC:dph, GOC:tb] comment: This term should not be used for direct annotation. It should be possible to make a more specific annotation to one of the children of this term. subset: gocheck_do_not_annotate is_a: GO:0009059 ! macromolecule biosynthetic process is_a: GO:0034654 ! nucleobase-containing compound biosynthetic process is_a: GO:0090304 ! nucleic acid metabolic process intersection_of: GO:0009058 ! biosynthetic process intersection_of: RO:0004008 CHEBI:33696 ! has primary output relationship: RO:0004008 CHEBI:33696 ! has primary output property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/27408" xsd:anyURI property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/27633" xsd:anyURI creation_date: 2024-03-25T07:33:40Z [Term] id: GO:0141188 name: nucleic acid catabolic process namespace: biological_process def: "The cellular DNA metabolic process resulting in the breakdown of a nucleic acid." [GOC:curators] comment: This term should not be used for direct annotation. It should be possible to make a more specific annotation to one of the children of this term. subset: gocheck_do_not_annotate is_a: GO:0009057 ! macromolecule catabolic process is_a: GO:0034655 ! nucleobase-containing compound catabolic process is_a: GO:0090304 ! nucleic acid metabolic process intersection_of: GO:0009056 ! catabolic process intersection_of: RO:0004009 CHEBI:33696 ! has primary input relationship: RO:0004009 CHEBI:33696 ! has primary input property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/27408" xsd:anyURI property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/27633" xsd:anyURI creation_date: 2024-03-25T07:35:06Z [Term] id: GO:0150031 name: regulation of protein localization to lysosome namespace: biological_process def: "Any process that modulates the frequency, rate or extent of protein localization to lysosome." [GOC:aruk, GOC:bc, PMID:24305806] is_a: GO:0032880 ! regulation of protein localization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0061462 ! regulates protein localization to lysosome relationship: RO:0002211 GO:0061462 ! regulates protein localization to lysosome creation_date: 2018-02-06T17:07:03Z [Term] id: GO:0150032 name: positive regulation of protein localization to lysosome namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of protein localization to lysosome." [GOC:aruk, GOC:bc] is_a: GO:0150031 ! regulation of protein localization to lysosome is_a: GO:1903829 ! positive regulation of protein localization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0061462 ! positively regulates protein localization to lysosome relationship: RO:0002213 GO:0061462 ! positively regulates protein localization to lysosome creation_date: 2018-02-06T17:11:02Z [Term] id: GO:0150033 name: negative regulation of protein localization to lysosome namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to lysosome." [GOC:aruk, GOC:bc, PMID:24305806] is_a: GO:0150031 ! regulation of protein localization to lysosome is_a: GO:1903828 ! negative regulation of protein localization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0061462 ! negatively regulates protein localization to lysosome relationship: RO:0002212 GO:0061462 ! negatively regulates protein localization to lysosome creation_date: 2018-02-06T17:14:16Z [Term] id: GO:0150034 name: distal axon namespace: cellular_component def: "That part of an axon close to and including the growth cone or the axon terminus." [GOC:aruk, GOC:bc, PMID:17202468] synonym: "distal part of axon" EXACT [] synonym: "distal part of the axon" EXACT [PMID:17202468] is_a: GO:0110165 ! cellular anatomical structure relationship: BFO:0000050 GO:0030424 ! part of axon creation_date: 2018-02-19T15:04:24Z [Term] id: GO:0150038 name: postsynaptic dense core vesicle exocytosis namespace: biological_process def: "The secretion of molecules (e.g. neuropeptides, insulin-related peptides or neuromodulators such as serotonin and dopamine) contained within a postsynaptic dense core vesicle by fusion of the granule with the plasma membrane of the postsynapse in response to increased cytosolic calcium levels." [GOC:aruk, GOC:bc, PMID:19448629] subset: goslim_synapse is_a: GO:0099003 ! vesicle-mediated transport in synapse is_a: GO:0099011 ! neuronal dense core vesicle exocytosis intersection_of: GO:0099011 ! neuronal dense core vesicle exocytosis intersection_of: BFO:0000066 GO:0098794 ! occurs in postsynapse relationship: BFO:0000066 GO:0098794 ! occurs in postsynapse creation_date: 2018-04-18T14:32:16Z [Term] id: GO:0150044 name: regulation of postsynaptic dense core vesicle exocytosis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of postsynaptic dense core vesicle exocytosis." [GOC:aruk, GOC:bc, PMID:19448629] subset: goslim_synapse is_a: GO:1905413 ! regulation of dense core granule exocytosis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0150038 ! regulates postsynaptic dense core vesicle exocytosis relationship: RO:0002211 GO:0150038 ! regulates postsynaptic dense core vesicle exocytosis creation_date: 2018-04-20T13:34:32Z [Term] id: GO:0150045 name: regulation of synaptic signaling by nitric oxide namespace: biological_process def: "Any process that modulates the frequency, rate or extent of synaptic signaling by nitric oxide." [GOC:aruk, GOC:bc, PMID:26311509] subset: goslim_synapse is_a: GO:0010646 ! regulation of cell communication is_a: GO:0023051 ! regulation of signaling intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0099163 ! regulates synaptic signaling by nitric oxide relationship: RO:0002211 GO:0099163 ! regulates synaptic signaling by nitric oxide creation_date: 2018-04-23T09:42:25Z [Term] id: GO:0150052 name: regulation of postsynapse assembly namespace: biological_process def: "Any process that modulates the frequency, rate or extent of postsynapse assembly, the aggregation, arrangement and bonding together of a set of components to form a postsynapse." [GOC:aruk, GOC:bc, PMID:16394100, PMID:16672654, PMID:28185854] subset: goslim_synapse is_a: GO:0051963 ! regulation of synapse assembly is_a: GO:0099175 ! regulation of postsynapse organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0099068 ! regulates postsynapse assembly relationship: RO:0002211 GO:0099068 ! regulates postsynapse assembly creation_date: 2018-05-08T16:38:55Z [Term] id: GO:0150063 name: visual system development namespace: biological_process def: "The process whose specific outcome is the progression of the visual system over time, from its formation to the mature structure, including the eye, parts of the central nervous system (CNS) involved in processing of visual inputs, and connecting nerve pathways." [GOC:aruk, GOC:bc, GOC:krc, PMID:15004427, PMID:20647017, PMID:22632727] synonym: "optic pathway development" RELATED [] synonym: "visual pathway development" RELATED [] is_a: GO:0048880 ! sensory system development creation_date: 2018-07-23T10:31:58Z [Term] id: GO:0150076 name: neuroinflammatory response namespace: biological_process def: "The immediate defensive reaction by neural vertebrate tissue to infection or injury caused by chemical or physical agents." [GOC:aruk, GOC:bc, PMID:10981966, PMID:11099416, PMID:18164423] synonym: "nerve tissue inflammatory response" EXACT [] synonym: "nervous tissue inflammatory response" EXACT [] synonym: "neural tissue inflammatory response" EXACT [] is_a: GO:0006954 ! inflammatory response creation_date: 2018-07-26T12:25:34Z [Term] id: GO:0150077 name: regulation of neuroinflammatory response namespace: biological_process def: "Any process that modulates the frequency, rate or extent of neuroinflammatory response." [GOC:aruk, GOC:bc, PMID:10981966, PMID:11099416, PMID:18164423] is_a: GO:0050727 ! regulation of inflammatory response intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0150076 ! regulates neuroinflammatory response relationship: RO:0002211 GO:0150076 ! regulates neuroinflammatory response creation_date: 2018-07-26T12:32:18Z [Term] id: GO:0150078 name: positive regulation of neuroinflammatory response namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of neuroinflammatory response." [GOC:aruk, GOC:bc] is_a: GO:0050729 ! positive regulation of inflammatory response is_a: GO:0150077 ! regulation of neuroinflammatory response intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0150076 ! positively regulates neuroinflammatory response relationship: RO:0002213 GO:0150076 ! positively regulates neuroinflammatory response creation_date: 2018-07-26T12:35:50Z [Term] id: GO:0150079 name: negative regulation of neuroinflammatory response namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of neuroinflammatory response." [GOC:aruk, GOC:bc, PMID:11099416, PMID:18164423] is_a: GO:0050728 ! negative regulation of inflammatory response is_a: GO:0150077 ! regulation of neuroinflammatory response intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0150076 ! negatively regulates neuroinflammatory response relationship: RO:0002212 GO:0150076 ! negatively regulates neuroinflammatory response creation_date: 2018-07-26T12:38:08Z [Term] id: GO:0150098 name: glial cell-neuron signaling namespace: biological_process def: "Cell-cell signaling that mediates the transfer of information from a glial cell to a neuron. This signaling has been shown to be mediated by various molecules, depending on which glial cells release them, and in which tissues the signaling occurs, e.g. microglial cell-derived nerve growth factor (NGF) in the retina, or microglial cell-derived superoxide ions in the cerebellum." [GOC:aruk, GOC:bc, PMID:14980203, PMID:16144764, PMID:16547515, PMID:18685038, PMID:27788368, PMID:9459440] synonym: "glia-neuron signaling" EXACT [] synonym: "glia-neuron signalling" EXACT [] synonym: "glia-neurone signaling" EXACT [] synonym: "glia-neurone signalling" EXACT [] synonym: "glial cell- neuron signalling" EXACT [] synonym: "glial cell-neurone signalling" EXACT [] synonym: "glial cell-neurone singaling" EXACT [] is_a: GO:0007267 ! cell-cell signaling intersection_of: GO:0007267 ! cell-cell signaling intersection_of: RO:0002231 CL:0000125 ! has start location glial cell intersection_of: RO:0002232 CL:0000540 ! has end location neuron relationship: RO:0002231 CL:0000125 ! has start location glial cell relationship: RO:0002232 CL:0000540 ! has end location neuron creation_date: 2018-12-17T12:28:09Z [Term] id: GO:0150099 name: neuron-glial cell signaling namespace: biological_process def: "Cell-cell signaling that mediates the transfer of information from a neuron to a glial cell. This signaling has been shown to be mediated by various molecules released by different types of neurons, e.g. glutamate, gamma-amino butyric acid (GABA), noradrenaline, acetylcholine, dopamine and adenosine." [GOC:aruk, GOC:bc, PMID:10195197, PMID:10196584, PMID:10377338, PMID:10493741, PMID:11356870, PMID:11399439, PMID:15252819, PMID:27788368] synonym: "neuron-glia signaling" EXACT [] synonym: "neuron-glia signalling" EXACT [] synonym: "neuron-glial cell signalling" EXACT [] synonym: "neurone-glia signaling" EXACT [] synonym: "neurone-glia signalling" EXACT [] synonym: "neurone-glial cell signaling" EXACT [] synonym: "neurone-glial cell signalling" EXACT [] is_a: GO:0007267 ! cell-cell signaling intersection_of: GO:0007267 ! cell-cell signaling intersection_of: RO:0002231 CL:0000540 ! has start location neuron intersection_of: RO:0002232 CL:0000125 ! has end location glial cell relationship: RO:0002231 CL:0000540 ! has start location neuron relationship: RO:0002232 CL:0000125 ! has end location glial cell creation_date: 2018-12-17T12:30:12Z [Term] id: GO:0150102 name: negative regulation of monocyte activation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of monocyte activation." [GOC:aruk, PMID:15597323] synonym: "repression of monocyte activation" EXACT [] is_a: GO:0002695 ! negative regulation of leukocyte activation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0042117 ! negatively regulates monocyte activation relationship: RO:0002212 GO:0042117 ! negatively regulates monocyte activation creation_date: 2019-04-26T20:01:24Z [Term] id: GO:0150104 name: transport across blood-brain barrier namespace: biological_process def: "The directed movement of substances (e.g. macromolecules, small molecules, ions) through the blood-brain barrier." [GOC:aruk, GOC:bc, PMID:29377008] synonym: "transport across BBB" EXACT [] synonym: "transport across blood brain barrier" EXACT [] is_a: BFO:0000003 is_a: GO:0010232 ! vascular transport intersection_of: GO:0010232 ! vascular transport intersection_of: RO:0002342 UBERON:0000120 ! results in transport across blood brain barrier relationship: RO:0002162 NCBITaxon:6072 ! in taxon Eumetazoa relationship: RO:0002342 UBERON:0000120 ! results in transport across blood brain barrier creation_date: 2019-05-27T09:12:03Z [Term] id: GO:0150105 name: protein localization to cell-cell junction namespace: biological_process def: "A process in which a protein is transported to, or maintained, in a location within a cell-cell junction." [GOC:aruk, GOC:bc, PMID:26706435] is_a: GO:1902414 ! protein localization to cell junction intersection_of: GO:0008104 ! intracellular protein localization intersection_of: RO:0002339 GO:0005911 ! has target end location cell-cell junction relationship: RO:0002339 GO:0005911 ! has target end location cell-cell junction creation_date: 2019-06-11T11:00:18Z [Term] id: GO:0150106 name: regulation of protein localization to cell-cell junction namespace: biological_process def: "Any process that modulates the frequency, rate or extent of protein localization to cell-cell junction." [GOC:aruk, GOC:bc, PMID:26706435] is_a: GO:0032880 ! regulation of protein localization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0150105 ! regulates protein localization to cell-cell junction relationship: RO:0002211 GO:0150105 ! regulates protein localization to cell-cell junction creation_date: 2019-06-11T11:17:15Z [Term] id: GO:0150107 name: positive regulation of protein localization to cell-cell junction namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of protein localization to cell-cell junction." [GOC:aruk, GOC:bc, PMID:26706435] is_a: GO:0150106 ! regulation of protein localization to cell-cell junction is_a: GO:1903829 ! positive regulation of protein localization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0150105 ! positively regulates protein localization to cell-cell junction relationship: RO:0002213 GO:0150105 ! positively regulates protein localization to cell-cell junction creation_date: 2019-06-11T11:23:58Z [Term] id: GO:0150111 name: regulation of transepithelial transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of transepithelial transport." [GOC:aruk, PMID:27593915] is_a: GO:0051049 ! regulation of transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0070633 ! regulates transepithelial transport relationship: RO:0002211 GO:0070633 ! regulates transepithelial transport creation_date: 2019-09-15T07:16:49Z [Term] id: GO:0150115 name: cell-substrate junction organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a cell-substrate junction. A cell-substrate junction is a specialized region of connection between a cell and the extracellular matrix." [GOC:aruk, GOC:bc, PMID:10419689, PMID:1643657, PMID:16805308, PMID:26923917, PMID:8314002] is_a: GO:0034330 ! cell junction organization intersection_of: GO:0034330 ! cell junction organization intersection_of: RO:0002592 GO:0030055 ! results in organization of cell-substrate junction relationship: RO:0002592 GO:0030055 ! results in organization of cell-substrate junction creation_date: 2019-11-14T11:06:29Z [Term] id: GO:0150116 name: regulation of cell-substrate junction organization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cell-substrate junction organization." [GOC:aruk] is_a: GO:0051128 ! regulation of cellular component organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0150115 ! regulates cell-substrate junction organization relationship: RO:0002211 GO:0150115 ! regulates cell-substrate junction organization creation_date: 2019-11-14T12:12:27Z [Term] id: GO:0150117 name: positive regulation of cell-substrate junction organization namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cell-substrate junction organization." [GOC:aruk] is_a: GO:0051130 ! positive regulation of cellular component organization is_a: GO:0150116 ! regulation of cell-substrate junction organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0150115 ! positively regulates cell-substrate junction organization relationship: RO:0002213 GO:0150115 ! positively regulates cell-substrate junction organization creation_date: 2019-11-14T12:15:07Z [Term] id: GO:0150118 name: negative regulation of cell-substrate junction organization namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of cell-substrate junction organization." [GOC:aruk] is_a: GO:0051129 ! negative regulation of cellular component organization is_a: GO:0150116 ! regulation of cell-substrate junction organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0150115 ! negatively regulates cell-substrate junction organization relationship: RO:0002212 GO:0150115 ! negatively regulates cell-substrate junction organization creation_date: 2019-11-14T12:16:32Z [Term] id: GO:0150119 name: negative regulation of protein localization to cell-cell junction namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to cell-cell junction." [GOC:aruk, GOC:bc] synonym: "negative regulation of protein localisation to cell-cell junction" EXACT [] is_a: GO:0150106 ! regulation of protein localization to cell-cell junction is_a: GO:1903828 ! negative regulation of protein localization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0150105 ! negatively regulates protein localization to cell-cell junction relationship: RO:0002212 GO:0150105 ! negatively regulates protein localization to cell-cell junction creation_date: 2019-11-21T13:53:34Z [Term] id: GO:0150146 name: cell junction disassembly namespace: biological_process def: "The disaggregation of a cell junction into its constituent components." [GOC:aruk, PMID:25490267] is_a: GO:0022411 ! cellular component disassembly is_a: GO:0034330 ! cell junction organization intersection_of: GO:0022411 ! cellular component disassembly intersection_of: RO:0002590 GO:0030054 ! results in disassembly of cell junction relationship: RO:0002590 GO:0030054 ! results in disassembly of cell junction creation_date: 2019-12-08T11:12:13Z [Term] id: GO:0150147 name: cell-cell junction disassembly namespace: biological_process def: "The disaggregation of a cell-cell junction into its constituent components." [GOC:aruk, PMID:25490267] is_a: GO:0045216 ! cell-cell junction organization is_a: GO:0150146 ! cell junction disassembly intersection_of: GO:0022411 ! cellular component disassembly intersection_of: RO:0002590 GO:0005911 ! results in disassembly of cell-cell junction relationship: RO:0002590 GO:0005911 ! results in disassembly of cell-cell junction creation_date: 2019-12-08T11:16:14Z [Term] id: GO:0150195 name: transport across blood-cerebrospinal fluid barrier namespace: biological_process def: "The directed movement of substances (e.g. macromolecules, small molecules, ions) through the blood-cerebrospinal fluid barrier." [GOC:aruk, GOC:bc, PMID:21349151] synonym: "transport across BCSFB" EXACT [] synonym: "transport across blood-CSF barrier" EXACT [] synonym: "transport across blood/cerebrospinal fluid barrier" EXACT [] synonym: "transport across blood/CSF barrier" EXACT [] is_a: BFO:0000003 is_a: GO:0010232 ! vascular transport intersection_of: GO:0006810 ! transport intersection_of: RO:0002342 UBERON:0003210 ! results in transport across blood-cerebrospinal fluid barrier relationship: RO:0002342 UBERON:0003210 ! results in transport across blood-cerebrospinal fluid barrier property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 creation_date: 2020-03-26T14:43:04Z [Term] id: GO:0150200 name: regulation of transport across blood-brain barrier namespace: biological_process def: "Any process that modulates the frequency, rate or extent of transport across the blood-brain barrier." [GOC:aruk, GOC:bc, PMID:29377008, PMID:30280653] is_a: GO:0044057 ! regulation of system process is_a: GO:0051049 ! regulation of transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0150104 ! regulates transport across blood-brain barrier relationship: BFO:0000050 GO:0043114 ! part of regulation of vascular permeability relationship: RO:0002211 GO:0150104 ! regulates transport across blood-brain barrier creation_date: 2020-03-26T19:22:26Z [Term] id: GO:0150201 name: positive regulation of transport across blood-brain barrier namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of transport across blood-brain barrier." [GOC:aruk, GOC:bc, PMID:29377008, PMID:30280653] is_a: GO:0051050 ! positive regulation of transport is_a: GO:0051240 ! positive regulation of multicellular organismal process is_a: GO:0150200 ! regulation of transport across blood-brain barrier intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0150104 ! positively regulates transport across blood-brain barrier relationship: BFO:0000050 GO:0043117 ! part of positive regulation of vascular permeability relationship: RO:0002213 GO:0150104 ! positively regulates transport across blood-brain barrier creation_date: 2020-03-26T19:26:38Z [Term] id: GO:0150202 name: negative regulation of transport across blood-brain barrier namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of transport across blood-brain barrier." [GOC:aruk, GOC:bc, PMID:29377008, PMID:30280653] is_a: GO:0051051 ! negative regulation of transport is_a: GO:0051241 ! negative regulation of multicellular organismal process is_a: GO:0150200 ! regulation of transport across blood-brain barrier intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0150104 ! negatively regulates transport across blood-brain barrier relationship: BFO:0000050 GO:0043116 ! part of negative regulation of vascular permeability relationship: RO:0002212 GO:0150104 ! negatively regulates transport across blood-brain barrier creation_date: 2020-03-26T19:28:51Z [Term] id: GO:0151001 name: tuft namespace: cellular_component def: "A dense cluster of elongated, thick microvilli on the apical surface of tuft cells in epithelial tissues, such as the intestine and respiratory tract. The apical tuft extends further into the lumen than typical microvilli, featuring larger, more compact projections with unique actin cores that penetrate deep into the cytoplasm, often reaching the perinuclear region. This distinctive structure, rich in microfilaments and microtubules, supports the chemosensory functions of the cell." [PMID:15817800, PMID:35237268] is_a: GO:0098862 ! cluster of actin-based cell projections relationship: BFO:0000050 CL:0002204 ! part of tuft cell relationship: BFO:0000051 GO:0005902 ! has part microvillus creation_date: 2024-11-14T11:13:07Z [Term] id: GO:0160024 name: Leydig cell proliferation namespace: biological_process def: "The multiplication or reproduction of Leydig cells, resulting in the expansion of a cell population. Leydig cells are interstitial cells located adjacent to the seminiferous tubules in the testis which produce testosterone." [PMID:29632025] is_a: BFO:0000003 is_a: GO:0008283 ! cell population proliferation intersection_of: GO:0008283 ! cell population proliferation intersection_of: RO:0012003 CL:0000178 ! acts on population of Leydig cell relationship: RO:0012003 CL:0000178 ! acts on population of Leydig cell property_value: RO:0002161 NCBITaxon:4751 creation_date: 2022-02-08T20:09:53Z [Term] id: GO:0160038 name: somatic sensory system development namespace: biological_process def: "The process whose specific outcome is the progression of a somatic sensory system over time from its formation to the mature structure. Somatic sensory system is the sensory system for the sense of touch and pain." [PMID:25832476, PMID:31399790] synonym: "somatosensory system development" EXACT [] is_a: GO:0048880 ! sensory system development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0003942 ! results in development of somatosensory system relationship: RO:0002296 UBERON:0003942 ! results in development of somatosensory system creation_date: 2022-07-07T16:49:26Z [Term] id: GO:0160043 name: catecholamine secretion, neurotransmission namespace: biological_process def: "The regulated release of catecholamine by a cell in which the catecholamine acts as a neurotransmitter." [PMID:10191060] is_a: GO:0007269 ! neurotransmitter secretion is_a: GO:0050432 ! catecholamine secretion intersection_of: GO:0007269 ! neurotransmitter secretion intersection_of: RO:0004009 CHEBI:33567 ! has primary input property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/23804" xsd:anyURI creation_date: 2022-08-17T00:36:44Z [Term] id: GO:0160048 name: craniofacial suture closure namespace: biological_process def: "The process of fusing together the edges of a craniofacial suture." [PMID:33842480] is_a: GO:0060349 ! bone morphogenesis intersection_of: GO:0060349 ! bone morphogenesis intersection_of: RO:0012008 UBERON:0009198 ! results in fusion of craniofacial suture relationship: RO:0012008 UBERON:0009198 ! results in fusion of craniofacial suture property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/23213" xsd:anyURI creation_date: 2022-08-19T23:18:54Z [Term] id: GO:0160083 name: exhausted T cell differentiation namespace: biological_process def: "The process in which an activated T cell acquires specialized features of an exhausted T cell." [PMID:21739672, PMID:31570879] synonym: "T cell dysfuction" RELATED [] synonym: "T cell exhaustion" EXACT [] is_a: GO:0030217 ! T cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0011025 ! results in acquisition of features of exhausted T cell relationship: RO:0002315 CL:0011025 ! results in acquisition of features of exhausted T cell property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/25698" xsd:anyURI creation_date: 2023-07-14T22:56:05Z [Term] id: GO:0160093 name: chordate pharynx development namespace: biological_process def: "The process whose specific outcome is the progression of cordate pharynx over time, from its formation to the mature structure." [PMID:23020903] is_a: GO:0060465 ! pharynx development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0001042 ! results in development of chordate pharynx relationship: RO:0002296 UBERON:0001042 ! results in development of chordate pharynx property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/18285" xsd:anyURI creation_date: 2023-08-29T21:05:28Z [Term] id: GO:0160133 name: bicarbonate channel activity namespace: molecular_function def: "Enables the energy-independent facilitated diffusion of bicarbonate through a transmembrane aqueous pore or channel." [PMID:18400985] synonym: "hydrogencarbonate channel activity" EXACT [] xref: RHEA:28695 {source="skos:broadMatch"} is_a: GO:0015106 ! bicarbonate transmembrane transporter activity is_a: GO:0015267 ! channel activity intersection_of: GO:0015267 ! channel activity intersection_of: RO:0004009 CHEBI:17544 ! has primary input property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/26601" xsd:anyURI property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/26780" xsd:anyURI property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/27521" xsd:anyURI creation_date: 2023-12-13T00:09:44Z [Term] id: GO:0160165 name: CD8-positive, alpha-beta T cell homeostasis namespace: biological_process def: "The process of regulating the proliferation and elimination of CD8-positive alpha-beta T cells such that the total number of CD8-positive alpha-beta T cells within a whole or part of an organism is stable over time in the absence of an outside stimulus." [PMID:30650357, PMID:33815406] synonym: "CD8+ T cell homeostasis" BROAD [] synonym: "CD8-positive T cell homeostasis" BROAD [] is_a: GO:0043029 ! T cell homeostasis intersection_of: GO:0048872 ! homeostasis of number of cells intersection_of: RO:0012003 CL:0000625 ! acts on population of CD8-positive, alpha-beta T cell relationship: RO:0012003 CL:0000625 ! acts on population of CD8-positive, alpha-beta T cell property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/27184" xsd:anyURI creation_date: 2024-03-04T23:49:25Z [Term] id: GO:0160173 name: histamine transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of histamine from one side of a membrane to the other." [PMID:36288320] is_a: GO:1901474 ! azole transmembrane transporter activity intersection_of: GO:0022857 ! transmembrane transporter activity intersection_of: RO:0004009 CHEBI:58432 ! has primary input relationship: RO:0004009 CHEBI:58432 ! has primary input property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/27277" xsd:anyURI creation_date: 2024-03-15T16:40:36Z [Term] id: GO:0160212 name: glycine-gated cation channel activity namespace: molecular_function def: "Enables the transmembrane transfer of a cation by a channel that opens when glycine is bound by the channel complex or one of its constituent parts on the extracellular side of the plasma membrane." [PMID:11823786] is_a: GO:0022824 ! transmitter-gated monoatomic ion channel activity is_a: GO:0099094 ! ligand-gated monoatomic cation channel activity intersection_of: GO:0022836 ! gated channel activity intersection_of: RO:0004009 CHEBI:23906 ! has primary input intersection_of: RO:0012001 CHEBI:57305 ! has small molecule activator relationship: RO:0012001 CHEBI:57305 ! has small molecule activator property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/28887" xsd:anyURI creation_date: 2024-09-10T16:55:41Z [Term] id: GO:0160231 name: cytospinule namespace: cellular_component def: "An actin-based cell projection extending laterally from the basolateral membrane of tuft cells in epithelial tissues, including the intestinal epithelium. These thin projections, typically 3-4 per cell and up to 3 micron long, directly contact the nuclei of adjacent epithelial cells, potentially facilitating intercellular communication and molecular exchange." [PMID:28490731, PMID:37863104] is_a: GO:0098858 ! actin-based cell projection property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/29509" xsd:anyURI creation_date: 2025-01-06T19:59:47Z [Term] id: GO:0160274 name: beige fat cell differentiation namespace: biological_process def: "The process in which a white fat cell acquires specialized features of a beige adipocyte. Beige adipocytes reside within white adipose tissue and can be induced to produce heat in response to cold exposure or certain stimuli, resembling brown adipocytes." [PMID:24439384] synonym: "brite fat cell differentiation" EXACT [] synonym: "brown-in white fat cell differentiation" EXACT [] is_a: GO:0045444 ! fat cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0001070 ! results in acquisition of features of beige adipocyte relationship: RO:0002315 CL:0001070 ! results in acquisition of features of beige adipocyte property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/30350" xsd:anyURI creation_date: 2025-06-02T23:06:17Z [Term] id: GO:0160275 name: negative regulation of white fat cell differentiation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of white fat cell differentiation." [PMID:24703692] is_a: GO:0045599 ! negative regulation of fat cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0050872 ! negatively regulates white fat cell differentiation relationship: RO:0002212 GO:0050872 ! negatively regulates white fat cell differentiation property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/30350" xsd:anyURI creation_date: 2025-06-02T23:14:39Z [Term] id: GO:0160276 name: negative regulation of beige fat cell differentiation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of beige fat cell differentiation." [PMID:35978186] is_a: GO:0045599 ! negative regulation of fat cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0160274 ! negatively regulates beige fat cell differentiation relationship: RO:0002212 GO:0160274 ! negatively regulates beige fat cell differentiation property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/30350" xsd:anyURI creation_date: 2025-06-04T16:07:37Z [Term] id: GO:0160307 name: protein biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of protein." [Wikipedia:Protein_biosynthesis] synonym: "protein biosynthesis" EXACT [] synonym: "protein synthesis" EXACT [] is_a: GO:0009059 ! macromolecule biosynthetic process is_a: GO:0019538 ! protein metabolic process intersection_of: GO:0009059 ! macromolecule biosynthetic process intersection_of: BFO:0000051 GO:0043039 ! has part tRNA aminoacylation intersection_of: RO:0004008 PR:000000001 ! has primary output protein relationship: BFO:0000050 GO:0010467 ! part of gene expression relationship: BFO:0000051 GO:0043039 ! has part tRNA aminoacylation relationship: RO:0004008 PR:000000001 ! has primary output protein property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/15375" xsd:anyURI creation_date: 2025-09-29T23:16:32Z [Term] id: GO:0170033 name: L-amino acid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving an L-amino acid." [GOC:edw] synonym: "L-alpha-amino acid metabolism" EXACT [] synonym: "L-amino acid metabolism" EXACT [] is_a: GO:1901605 ! alpha-amino acid metabolic process intersection_of: GO:0008152 ! metabolic process intersection_of: RO:0004007 CHEBI:59869 ! has primary input or output relationship: RO:0004007 CHEBI:59869 ! has primary input or output property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/23268" xsd:anyURI creation_date: 2023-11-20T23:41:23Z [Term] id: GO:0170034 name: L-amino acid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of L-amino acids, the L-enantiomers of amino acids." [GOC:edw] synonym: "L-amino acid anabolism" EXACT [] synonym: "L-amino acid biosynthesis" EXACT [] synonym: "L-amino acid formation" EXACT [] synonym: "L-amino acid synthesis" EXACT [] is_a: GO:0170033 ! L-amino acid metabolic process is_a: GO:1901607 ! alpha-amino acid biosynthetic process intersection_of: GO:0009058 ! biosynthetic process intersection_of: RO:0004008 CHEBI:59869 ! has primary output relationship: RO:0004008 CHEBI:59869 ! has primary output property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/23268" xsd:anyURI creation_date: 2023-11-20T23:42:06Z [Term] id: GO:0170035 name: L-amino acid catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of an L-amino acid." [GOC:edw] synonym: "L-amino acid breakdown" EXACT [] synonym: "L-amino acid catabolism" EXACT [] synonym: "L-amino acid degradation" EXACT [] is_a: GO:0170033 ! L-amino acid metabolic process is_a: GO:1901606 ! alpha-amino acid catabolic process intersection_of: GO:0009056 ! catabolic process intersection_of: RO:0004009 CHEBI:59869 ! has primary input relationship: RO:0004009 CHEBI:59869 ! has primary input property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/23268" xsd:anyURI creation_date: 2023-11-21T00:55:07Z [Term] id: GO:0170036 name: import into the mitochondrion namespace: biological_process def: "The directed movement of substances from the cytosol into the mitochondrion." [GOC:ew] is_a: GO:1990542 ! mitochondrial transmembrane transport intersection_of: GO:0046907 ! intracellular transport intersection_of: RO:0002338 GO:0005829 ! has target start location cytosol intersection_of: RO:0002339 GO:0005759 ! has target end location mitochondrial matrix intersection_of: RO:0002342 GO:0031966 ! results in transport across mitochondrial membrane relationship: RO:0002338 GO:0005829 ! has target start location cytosol relationship: RO:0002339 GO:0005759 ! has target end location mitochondrial matrix property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/26201" xsd:anyURI creation_date: 2023-11-30T20:56:49Z [Term] id: GO:0170037 name: export from the mitochondrion namespace: biological_process def: "The directed movement of substances from the mitochondrion to the cytosol." [GOC:ew] is_a: GO:1990542 ! mitochondrial transmembrane transport intersection_of: GO:0046907 ! intracellular transport intersection_of: RO:0002338 GO:0005759 ! has target start location mitochondrial matrix intersection_of: RO:0002339 GO:0005829 ! has target end location cytosol intersection_of: RO:0002342 GO:0031966 ! results in transport across mitochondrial membrane relationship: RO:0002338 GO:0005759 ! has target start location mitochondrial matrix relationship: RO:0002339 GO:0005829 ! has target end location cytosol property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/26201" xsd:anyURI creation_date: 2023-11-30T21:03:28Z [Term] id: GO:0170038 name: proteinogenic amino acid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of any amino acid that is incorporated into protein naturally by ribosomal translation of mRNA, and that has a specific codon for translation from mRNA to protein." [GOC:ew] synonym: "proteinogenic amino acid anabolism" EXACT [] synonym: "proteinogenic amino acid biosynthesis" EXACT [] synonym: "proteinogenic amino acid formation" EXACT [] synonym: "proteinogenic amino acid synthesis" EXACT [] is_a: GO:0046394 ! carboxylic acid biosynthetic process is_a: GO:0170039 ! proteinogenic amino acid metabolic process intersection_of: GO:0009058 ! biosynthetic process intersection_of: RO:0004008 CHEBI:83813 ! has primary output relationship: RO:0004008 CHEBI:83813 ! has primary output property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/23268" xsd:anyURI creation_date: 2023-12-18T16:28:19Z [Term] id: GO:0170039 name: proteinogenic amino acid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving any amino acid that is incorporated into protein naturally by ribosomal translation of mRNA, and that has a specific codon for translation from mRNA to protein." [GOC:ew] synonym: "proteinogenic amino acid metabolism" EXACT [] is_a: GO:0006520 ! amino acid metabolic process is_a: GO:0019752 ! carboxylic acid metabolic process intersection_of: GO:0008152 ! metabolic process intersection_of: RO:0004007 CHEBI:83813 ! has primary input or output relationship: RO:0004007 CHEBI:83813 ! has primary input or output property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/23268" xsd:anyURI creation_date: 2023-12-18T17:31:08Z [Term] id: GO:0170040 name: proteinogenic amino acid catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of any amino acid that is incorporated into protein naturally by ribosomal translation of mRNA, and that has a specific codon for translation from mRNA to protein." [GOC:ew] synonym: "proteinogenic amino acid breakdown" EXACT [] synonym: "proteinogenic amino acid catabolism" EXACT [] synonym: "proteinogenic amino acid degradation" EXACT [] is_a: GO:0046395 ! carboxylic acid catabolic process is_a: GO:0170039 ! proteinogenic amino acid metabolic process intersection_of: GO:0009056 ! catabolic process intersection_of: RO:0004009 CHEBI:83813 ! has primary input relationship: RO:0004009 CHEBI:83813 ! has primary input property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/23268" xsd:anyURI creation_date: 2023-12-18T17:41:14Z [Term] id: GO:0170041 name: non-proteinogenic amino acid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving non-proteingenic amino acids." [GOC:ew] synonym: "non-proteinogenic amino acid metabolism" EXACT [] is_a: GO:0006520 ! amino acid metabolic process is_a: GO:0019752 ! carboxylic acid metabolic process intersection_of: GO:0008152 ! metabolic process intersection_of: RO:0004007 CHEBI:83820 ! has primary input or output relationship: RO:0004007 CHEBI:83820 ! has primary input or output property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/23269" xsd:anyURI creation_date: 2023-12-18T17:57:55Z [Term] id: GO:0170043 name: non-proteinogenic amino acid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of non-proteinogenic amino acids." [GOC:ew] synonym: "non-proteinogenic amino acid anabolism" EXACT [] synonym: "non-proteinogenic amino acid formation" EXACT [] synonym: "non-proteinogenic amino acid synthesis" EXACT [] synonym: "non-proteinogenic biosynthesis" EXACT [] is_a: GO:0046394 ! carboxylic acid biosynthetic process is_a: GO:0170041 ! non-proteinogenic amino acid metabolic process intersection_of: GO:0009058 ! biosynthetic process intersection_of: RO:0004008 CHEBI:83820 ! has primary output relationship: RO:0004008 CHEBI:83820 ! has primary output property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/23269" xsd:anyURI creation_date: 2023-12-18T19:03:08Z [Term] id: GO:0170044 name: non-proteinogenic amino acid catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of non-proteinogenic amino acids." [GOC:ew] synonym: "non-proteinogenic amino acid breakdown" EXACT [] synonym: "non-proteinogenic amino acid catabolism" EXACT [] synonym: "non-proteinogenic amino acid degradation" EXACT [] is_a: GO:0046395 ! carboxylic acid catabolic process is_a: GO:0170041 ! non-proteinogenic amino acid metabolic process intersection_of: GO:0009056 ! catabolic process intersection_of: RO:0004009 CHEBI:83820 ! has primary input relationship: RO:0004009 CHEBI:83820 ! has primary input property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/23269" xsd:anyURI creation_date: 2023-12-18T19:27:05Z [Term] id: GO:0170055 name: lipid transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of a lipid from one side of a membrane to the other." [GOC:curators] subset: gocheck_do_not_annotate is_a: GO:0005319 ! lipid transporter activity is_a: GO:0022857 ! transmembrane transporter activity intersection_of: GO:0022857 ! transmembrane transporter activity intersection_of: RO:0004009 CHEBI:18059 ! has primary input property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/27252" xsd:anyURI creation_date: 2024-03-15T18:47:58Z [Term] id: GO:0180064 name: protein O-linked glycosylation via xylose namespace: biological_process def: "A glycoprotein biosynthetic process starting with the covalent linkage of a xylose via a beta-glycosidic bond to the oxygen atom of a serine or a threonine side chain in a protein, which can be further elongated with the sequential addition of sugar units resulting in the formation of a protein O-linked glycan." [PMID:22117070] synonym: "protein O-linked xylosylation" RELATED [] is_a: GO:0006493 ! protein O-linked glycosylation property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/30362" xsd:anyURI property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/30592" xsd:anyURI creation_date: 2025-06-03T13:29:21Z [Term] id: GO:1900006 name: positive regulation of dendrite development namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of dendrite development." [GOC:TermGenie] synonym: "up regulation of dendrite development" RELATED [GOC:TermGenie] is_a: GO:0010976 ! positive regulation of neuron projection development is_a: GO:0050773 ! regulation of dendrite development is_a: GO:0051094 ! positive regulation of developmental process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0016358 ! positively regulates dendrite development relationship: RO:0002213 GO:0016358 ! positively regulates dendrite development creation_date: 2012-01-09T10:41:31Z [Term] id: GO:1900015 name: regulation of cytokine production involved in inflammatory response namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cytokine production involved in inflammatory response." [GOC:TermGenie] synonym: "regulation of cytokine production involved in acute inflammatory response" NARROW [GOC:TermGenie] is_a: GO:0001817 ! regulation of cytokine production intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0002534 ! regulates cytokine production involved in inflammatory response relationship: RO:0002211 GO:0002534 ! regulates cytokine production involved in inflammatory response creation_date: 2012-01-11T09:34:27Z [Term] id: GO:1900016 name: negative regulation of cytokine production involved in inflammatory response namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of cytokine production involved in inflammatory response." [GOC:TermGenie] synonym: "down regulation of cytokine production involved in acute inflammatory response" BROAD [GOC:TermGenie] synonym: "down regulation of cytokine production involved in inflammatory response" RELATED [GOC:TermGenie] synonym: "negative regulation of cytokine production involved in acute inflammatory response" NARROW [GOC:TermGenie] is_a: GO:0001818 ! negative regulation of cytokine production is_a: GO:1900015 ! regulation of cytokine production involved in inflammatory response intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0002534 ! negatively regulates cytokine production involved in inflammatory response relationship: RO:0002212 GO:0002534 ! negatively regulates cytokine production involved in inflammatory response creation_date: 2012-01-11T09:34:31Z [Term] id: GO:1900017 name: positive regulation of cytokine production involved in inflammatory response namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cytokine production involved in inflammatory response." [GOC:TermGenie] synonym: "positive regulation of cytokine production involved in acute inflammatory response" NARROW [GOC:TermGenie] synonym: "up regulation of cytokine production involved in acute inflammatory response" BROAD [GOC:TermGenie] synonym: "up regulation of cytokine production involved in inflammatory response" RELATED [GOC:TermGenie] is_a: GO:0001819 ! positive regulation of cytokine production is_a: GO:1900015 ! regulation of cytokine production involved in inflammatory response intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0002534 ! positively regulates cytokine production involved in inflammatory response relationship: RO:0002213 GO:0002534 ! positively regulates cytokine production involved in inflammatory response creation_date: 2012-01-11T09:34:35Z [Term] id: GO:1900046 name: regulation of hemostasis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of hemostasis." [GOC:TermGenie] is_a: GO:0050789 ! regulation of biological process is_a: GO:0050878 ! regulation of body fluid levels intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0007599 ! regulates hemostasis relationship: RO:0002211 GO:0007599 ! regulates hemostasis creation_date: 2012-01-19T03:23:38Z [Term] id: GO:1900047 name: negative regulation of hemostasis namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of hemostasis." [GOC:TermGenie] synonym: "down regulation of hemostasis" EXACT [GOC:TermGenie] synonym: "down-regulation of hemostasis" EXACT [GOC:TermGenie] synonym: "downregulation of hemostasis" EXACT [GOC:TermGenie] synonym: "inhibition of hemostasis" NARROW [GOC:TermGenie] is_a: GO:0048519 ! negative regulation of biological process is_a: GO:1900046 ! regulation of hemostasis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0007599 ! negatively regulates hemostasis relationship: RO:0002212 GO:0007599 ! negatively regulates hemostasis creation_date: 2012-01-19T03:23:42Z [Term] id: GO:1900048 name: positive regulation of hemostasis namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of hemostasis." [GOC:TermGenie] synonym: "activation of hemostasis" NARROW [GOC:TermGenie] synonym: "up regulation of hemostasis" EXACT [GOC:TermGenie] synonym: "up-regulation of hemostasis" EXACT [GOC:TermGenie] synonym: "upregulation of hemostasis" EXACT [GOC:TermGenie] is_a: GO:0048518 ! positive regulation of biological process is_a: GO:1900046 ! regulation of hemostasis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0007599 ! positively regulates hemostasis relationship: RO:0002213 GO:0007599 ! positively regulates hemostasis creation_date: 2012-01-19T03:23:45Z [Term] id: GO:1900073 name: regulation of neuromuscular synaptic transmission namespace: biological_process def: "Any process that modulates the frequency, rate or extent of neuromuscular synaptic transmission." [GOC:kmv, GOC:TermGenie] is_a: GO:0050804 ! modulation of chemical synaptic transmission intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0007274 ! regulates neuromuscular synaptic transmission relationship: RO:0002211 GO:0007274 ! regulates neuromuscular synaptic transmission creation_date: 2012-01-26T10:14:10Z [Term] id: GO:1900074 name: negative regulation of neuromuscular synaptic transmission namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of neuromuscular synaptic transmission." [GOC:kmv, GOC:TermGenie] synonym: "down regulation of neuromuscular synaptic transmission" RELATED [GOC:TermGenie] synonym: "down-regulation of neuromuscular synaptic transmission" RELATED [GOC:TermGenie] synonym: "downregulation of neuromuscular synaptic transmission" RELATED [GOC:TermGenie] synonym: "inhibition of neuromuscular synaptic transmission" RELATED [GOC:TermGenie] is_a: GO:0050805 ! negative regulation of synaptic transmission is_a: GO:1900073 ! regulation of neuromuscular synaptic transmission intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0007274 ! negatively regulates neuromuscular synaptic transmission relationship: RO:0002212 GO:0007274 ! negatively regulates neuromuscular synaptic transmission creation_date: 2012-01-26T10:14:18Z [Term] id: GO:1900075 name: positive regulation of neuromuscular synaptic transmission namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of neuromuscular synaptic transmission." [GOC:kmv, GOC:TermGenie] synonym: "activation of neuromuscular synaptic transmission" RELATED [GOC:TermGenie] synonym: "up regulation of neuromuscular synaptic transmission" RELATED [GOC:TermGenie] synonym: "up-regulation of neuromuscular synaptic transmission" RELATED [GOC:TermGenie] synonym: "upregulation of neuromuscular synaptic transmission" RELATED [GOC:TermGenie] is_a: GO:0050806 ! positive regulation of synaptic transmission is_a: GO:1900073 ! regulation of neuromuscular synaptic transmission intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0007274 ! positively regulates neuromuscular synaptic transmission relationship: RO:0002213 GO:0007274 ! positively regulates neuromuscular synaptic transmission creation_date: 2012-01-26T10:14:22Z [Term] id: GO:1900076 name: regulation of cellular response to insulin stimulus namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cellular response to insulin stimulus." [GOC:TermGenie, GOC:yaf] is_a: GO:0048583 ! regulation of response to stimulus is_a: GO:0050794 ! regulation of cellular process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0032869 ! regulates cellular response to insulin stimulus relationship: RO:0002211 GO:0032869 ! regulates cellular response to insulin stimulus property_value: RO:0002161 NCBITaxon:4751 creation_date: 2012-01-31T11:22:22Z [Term] id: GO:1900077 name: negative regulation of cellular response to insulin stimulus namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of cellular response to insulin stimulus." [GOC:TermGenie, GOC:yaf] synonym: "down regulation of cellular response to insulin stimulus" EXACT [GOC:TermGenie] synonym: "down-regulation of cellular response to insulin stimulus" EXACT [GOC:TermGenie] synonym: "downregulation of cellular response to insulin stimulus" EXACT [GOC:TermGenie] synonym: "inhibition of cellular response to insulin stimulus" NARROW [GOC:TermGenie] is_a: GO:0048523 ! negative regulation of cellular process is_a: GO:0048585 ! negative regulation of response to stimulus is_a: GO:1900076 ! regulation of cellular response to insulin stimulus intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0032869 ! negatively regulates cellular response to insulin stimulus relationship: RO:0002212 GO:0032869 ! negatively regulates cellular response to insulin stimulus property_value: RO:0002161 NCBITaxon:4751 creation_date: 2012-01-31T11:23:15Z [Term] id: GO:1900078 name: positive regulation of cellular response to insulin stimulus namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cellular response to insulin stimulus." [GOC:TermGenie, GOC:yaf] synonym: "activation of cellular response to insulin stimulus" NARROW [GOC:TermGenie] synonym: "up regulation of cellular response to insulin stimulus" EXACT [GOC:TermGenie] synonym: "up-regulation of cellular response to insulin stimulus" EXACT [GOC:TermGenie] synonym: "upregulation of cellular response to insulin stimulus" EXACT [GOC:TermGenie] is_a: GO:0048522 ! positive regulation of cellular process is_a: GO:0048584 ! positive regulation of response to stimulus is_a: GO:1900076 ! regulation of cellular response to insulin stimulus intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0032869 ! positively regulates cellular response to insulin stimulus relationship: RO:0002213 GO:0032869 ! positively regulates cellular response to insulin stimulus property_value: RO:0002161 NCBITaxon:4751 creation_date: 2012-01-31T11:24:30Z [Term] id: GO:1900098 name: regulation of plasma cell differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of plasma cell differentiation." [GOC:TermGenie] synonym: "regulation of plasma cell development" RELATED [GOC:TermGenie] is_a: GO:0002697 ! regulation of immune effector process is_a: GO:0045577 ! regulation of B cell differentiation is_a: GO:0050776 ! regulation of immune response intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0002317 ! regulates plasma cell differentiation relationship: RO:0002211 GO:0002317 ! regulates plasma cell differentiation creation_date: 2012-02-15T10:46:00Z [Term] id: GO:1900099 name: negative regulation of plasma cell differentiation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of plasma cell differentiation." [GOC:TermGenie] synonym: "down regulation of plasma cell development" RELATED [GOC:TermGenie] synonym: "down regulation of plasma cell differentiation" EXACT [GOC:TermGenie] synonym: "down-regulation of plasma cell development" RELATED [GOC:TermGenie] synonym: "down-regulation of plasma cell differentiation" EXACT [GOC:TermGenie] synonym: "downregulation of plasma cell development" RELATED [GOC:TermGenie] synonym: "downregulation of plasma cell differentiation" EXACT [GOC:TermGenie] synonym: "inhibition of plasma cell development" RELATED [GOC:TermGenie] synonym: "inhibition of plasma cell differentiation" NARROW [GOC:TermGenie] synonym: "negative regulation of plasma cell development" RELATED [GOC:TermGenie] is_a: GO:0002698 ! negative regulation of immune effector process is_a: GO:0045578 ! negative regulation of B cell differentiation is_a: GO:0050777 ! negative regulation of immune response is_a: GO:1900098 ! regulation of plasma cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0002317 ! negatively regulates plasma cell differentiation relationship: RO:0002212 GO:0002317 ! negatively regulates plasma cell differentiation creation_date: 2012-02-15T10:46:05Z [Term] id: GO:1900100 name: positive regulation of plasma cell differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of plasma cell differentiation." [GOC:TermGenie] synonym: "activation of plasma cell development" RELATED [GOC:TermGenie] synonym: "activation of plasma cell differentiation" NARROW [GOC:TermGenie] synonym: "positive regulation of plasma cell development" RELATED [GOC:TermGenie] synonym: "up regulation of plasma cell development" RELATED [GOC:TermGenie] synonym: "up regulation of plasma cell differentiation" EXACT [GOC:TermGenie] synonym: "up-regulation of plasma cell development" RELATED [GOC:TermGenie] synonym: "up-regulation of plasma cell differentiation" EXACT [GOC:TermGenie] synonym: "upregulation of plasma cell development" RELATED [GOC:TermGenie] synonym: "upregulation of plasma cell differentiation" EXACT [GOC:TermGenie] is_a: GO:0002699 ! positive regulation of immune effector process is_a: GO:0045579 ! positive regulation of B cell differentiation is_a: GO:0050778 ! positive regulation of immune response is_a: GO:1900098 ! regulation of plasma cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0002317 ! positively regulates plasma cell differentiation relationship: RO:0002213 GO:0002317 ! positively regulates plasma cell differentiation creation_date: 2012-02-15T10:46:08Z [Term] id: GO:1900115 name: extracellular regulation of signal transduction namespace: biological_process def: "Any regulation of signal transduction that takes place in the extracellular region." [GOC:signaling, GOC:TermGenie] synonym: "regulation of signaling pathway in extracellular region" EXACT [GOC:TermGenie] synonym: "regulation of signalling pathway in extracellular region" EXACT [GOC:TermGenie] is_a: GO:0009966 ! regulation of signal transduction intersection_of: GO:0009966 ! regulation of signal transduction intersection_of: BFO:0000066 GO:0005576 ! occurs in extracellular region relationship: BFO:0000066 GO:0005576 ! occurs in extracellular region creation_date: 2012-02-22T10:21:48Z [Term] id: GO:1900116 name: extracellular negative regulation of signal transduction namespace: biological_process def: "Any negative regulation of signal transduction that takes place in extracellular region." [GOC:signaling, GOC:TermGenie] synonym: "down regulation of signal transduction in extracellular region" EXACT [GOC:TermGenie] synonym: "down-regulation of signal transduction in extracellular region" EXACT [GOC:TermGenie] synonym: "downregulation of signal transduction in extracellular region" EXACT [GOC:TermGenie] synonym: "extracellular inhibition of signaling pathway" NARROW [GOC:bf] synonym: "inhibition of signal transduction in extracellular region" NARROW [GOC:TermGenie] synonym: "negative regulation of signaling pathway in extracellular region" EXACT [GOC:TermGenie] synonym: "negative regulation of signalling pathway in extracellular region" EXACT [GOC:TermGenie] is_a: GO:0009968 ! negative regulation of signal transduction is_a: GO:1900115 ! extracellular regulation of signal transduction intersection_of: GO:0009968 ! negative regulation of signal transduction intersection_of: BFO:0000066 GO:0005576 ! occurs in extracellular region creation_date: 2012-02-22T10:27:56Z [Term] id: GO:1900117 name: regulation of execution phase of apoptosis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of execution phase of apoptosis." [GOC:mtg_apoptosis, GOC:TermGenie] is_a: GO:0050794 ! regulation of cellular process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0097194 ! regulates execution phase of apoptosis relationship: RO:0002211 GO:0097194 ! regulates execution phase of apoptosis property_value: RO:0002161 NCBITaxon:4896 creation_date: 2012-02-22T11:26:20Z [Term] id: GO:1900118 name: negative regulation of execution phase of apoptosis namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of execution phase of apoptosis." [GOC:mtg_apoptosis, GOC:TermGenie] synonym: "down regulation of execution phase of apoptosis" EXACT [GOC:TermGenie] synonym: "down-regulation of execution phase of apoptosis" EXACT [GOC:TermGenie] synonym: "downregulation of execution phase of apoptosis" EXACT [GOC:TermGenie] synonym: "inhibition of execution phase of apoptosis" NARROW [GOC:TermGenie] is_a: GO:0043066 ! negative regulation of apoptotic process is_a: GO:1900117 ! regulation of execution phase of apoptosis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0097194 ! negatively regulates execution phase of apoptosis relationship: RO:0002212 GO:0097194 ! negatively regulates execution phase of apoptosis property_value: RO:0002161 NCBITaxon:4896 creation_date: 2012-02-22T11:26:24Z [Term] id: GO:1900119 name: positive regulation of execution phase of apoptosis namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of execution phase of apoptosis." [GOC:mtg_apoptosis, GOC:TermGenie] synonym: "activation of execution phase of apoptosis" NARROW [GOC:TermGenie] synonym: "up regulation of execution phase of apoptosis" EXACT [GOC:TermGenie] synonym: "up-regulation of execution phase of apoptosis" EXACT [GOC:TermGenie] synonym: "upregulation of execution phase of apoptosis" EXACT [GOC:TermGenie] is_a: GO:0043065 ! positive regulation of apoptotic process is_a: GO:1900117 ! regulation of execution phase of apoptosis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0097194 ! positively regulates execution phase of apoptosis relationship: RO:0002213 GO:0097194 ! positively regulates execution phase of apoptosis property_value: RO:0002161 NCBITaxon:4896 creation_date: 2012-02-22T11:26:27Z [Term] id: GO:1900120 name: regulation of receptor binding namespace: biological_process def: "Any process that modulates the frequency, rate or extent of a protein or other molecule binding to a receptor." [GOC:signaling, GOC:TermGenie] subset: gocheck_do_not_annotate synonym: "regulation of receptor ligand" NARROW [GOC:TermGenie] is_a: GO:0043393 ! regulation of protein binding intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0005102 ! regulates signaling receptor binding relationship: RO:0002211 GO:0005102 ! regulates signaling receptor binding creation_date: 2012-02-22T11:40:53Z [Term] id: GO:1900121 name: negative regulation of receptor binding namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of a protein or other molecule binding to a receptor." [GOC:signaling, GOC:TermGenie] subset: gocheck_do_not_annotate synonym: "down regulation of receptor binding" EXACT [GOC:TermGenie] synonym: "down regulation of receptor-associated protein activity" RELATED [GOC:TermGenie] synonym: "down-regulation of receptor binding" EXACT [GOC:TermGenie] synonym: "downregulation of receptor binding" EXACT [GOC:TermGenie] synonym: "inhibition of receptor binding" NARROW [GOC:TermGenie] synonym: "inhibition of receptor ligand" NARROW [GOC:TermGenie] is_a: GO:0032091 ! negative regulation of protein binding is_a: GO:1900120 ! regulation of receptor binding intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0005102 ! negatively regulates signaling receptor binding relationship: RO:0002212 GO:0005102 ! negatively regulates signaling receptor binding creation_date: 2012-02-22T11:40:57Z [Term] id: GO:1900125 name: regulation of hyaluronan biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of hyaluronan biosynthetic process." [GOC:TermGenie, GOC:yaf] synonym: "regulation of hyaluronan anabolism" EXACT [GOC:TermGenie] synonym: "regulation of hyaluronan biosynthesis" EXACT [GOC:TermGenie] synonym: "regulation of hyaluronan formation" EXACT [GOC:TermGenie] synonym: "regulation of hyaluronan synthesis" EXACT [GOC:TermGenie] is_a: GO:0032885 ! regulation of polysaccharide biosynthetic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0030213 ! regulates hyaluronan biosynthetic process relationship: RO:0002211 GO:0030213 ! regulates hyaluronan biosynthetic process creation_date: 2012-02-23T01:09:21Z [Term] id: GO:1900126 name: negative regulation of hyaluronan biosynthetic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of hyaluronan biosynthetic process." [GOC:TermGenie, GOC:yaf] synonym: "down regulation of hyaluronan anabolism" EXACT [GOC:TermGenie] synonym: "down regulation of hyaluronan biosynthesis" EXACT [GOC:TermGenie] synonym: "down regulation of hyaluronan biosynthetic process" EXACT [GOC:TermGenie] synonym: "down regulation of hyaluronan formation" EXACT [GOC:TermGenie] synonym: "down regulation of hyaluronan synthesis" EXACT [GOC:TermGenie] synonym: "down-regulation of hyaluronan anabolism" EXACT [GOC:TermGenie] synonym: "down-regulation of hyaluronan biosynthesis" EXACT [GOC:TermGenie] synonym: "down-regulation of hyaluronan biosynthetic process" EXACT [GOC:TermGenie] synonym: "down-regulation of hyaluronan formation" EXACT [GOC:TermGenie] synonym: "down-regulation of hyaluronan synthesis" EXACT [GOC:TermGenie] synonym: "downregulation of hyaluronan anabolism" EXACT [GOC:TermGenie] synonym: "downregulation of hyaluronan biosynthesis" EXACT [GOC:TermGenie] synonym: "downregulation of hyaluronan biosynthetic process" EXACT [GOC:TermGenie] synonym: "downregulation of hyaluronan formation" EXACT [GOC:TermGenie] synonym: "downregulation of hyaluronan synthesis" EXACT [GOC:TermGenie] synonym: "inhibition of hyaluronan anabolism" EXACT [GOC:TermGenie] synonym: "inhibition of hyaluronan biosynthesis" EXACT [GOC:TermGenie] synonym: "inhibition of hyaluronan biosynthetic process" NARROW [GOC:TermGenie] synonym: "inhibition of hyaluronan formation" EXACT [GOC:TermGenie] synonym: "inhibition of hyaluronan synthesis" EXACT [GOC:TermGenie] synonym: "negative regulation of hyaluronan anabolism" EXACT [GOC:TermGenie] synonym: "negative regulation of hyaluronan biosynthesis" EXACT [GOC:TermGenie] synonym: "negative regulation of hyaluronan formation" EXACT [GOC:TermGenie] synonym: "negative regulation of hyaluronan synthesis" EXACT [GOC:TermGenie] is_a: GO:0010558 ! negative regulation of macromolecule biosynthetic process is_a: GO:0045912 ! negative regulation of carbohydrate metabolic process is_a: GO:1900125 ! regulation of hyaluronan biosynthetic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0030213 ! negatively regulates hyaluronan biosynthetic process relationship: RO:0002212 GO:0030213 ! negatively regulates hyaluronan biosynthetic process creation_date: 2012-02-23T01:09:29Z [Term] id: GO:1900127 name: positive regulation of hyaluronan biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of hyaluronan biosynthetic process." [GOC:TermGenie, GOC:yaf] synonym: "activation of hyaluronan anabolism" EXACT [GOC:TermGenie] synonym: "activation of hyaluronan biosynthesis" EXACT [GOC:TermGenie] synonym: "activation of hyaluronan biosynthetic process" NARROW [GOC:TermGenie] synonym: "activation of hyaluronan formation" EXACT [GOC:TermGenie] synonym: "activation of hyaluronan synthesis" EXACT [GOC:TermGenie] synonym: "positive regulation of hyaluronan anabolism" EXACT [GOC:TermGenie] synonym: "positive regulation of hyaluronan biosynthesis" EXACT [GOC:TermGenie] synonym: "positive regulation of hyaluronan formation" EXACT [GOC:TermGenie] synonym: "positive regulation of hyaluronan synthesis" EXACT [GOC:TermGenie] synonym: "up regulation of hyaluronan anabolism" EXACT [GOC:TermGenie] synonym: "up regulation of hyaluronan biosynthesis" EXACT [GOC:TermGenie] synonym: "up regulation of hyaluronan biosynthetic process" EXACT [GOC:TermGenie] synonym: "up regulation of hyaluronan formation" EXACT [GOC:TermGenie] synonym: "up regulation of hyaluronan synthesis" EXACT [GOC:TermGenie] synonym: "up-regulation of hyaluronan anabolism" EXACT [GOC:TermGenie] synonym: "up-regulation of hyaluronan biosynthesis" EXACT [GOC:TermGenie] synonym: "up-regulation of hyaluronan biosynthetic process" EXACT [GOC:TermGenie] synonym: "up-regulation of hyaluronan formation" EXACT [GOC:TermGenie] synonym: "up-regulation of hyaluronan synthesis" EXACT [GOC:TermGenie] synonym: "upregulation of hyaluronan anabolism" EXACT [GOC:TermGenie] synonym: "upregulation of hyaluronan biosynthesis" EXACT [GOC:TermGenie] synonym: "upregulation of hyaluronan biosynthetic process" EXACT [GOC:TermGenie] synonym: "upregulation of hyaluronan formation" EXACT [GOC:TermGenie] synonym: "upregulation of hyaluronan synthesis" EXACT [GOC:TermGenie] is_a: GO:0010557 ! positive regulation of macromolecule biosynthetic process is_a: GO:0045913 ! positive regulation of carbohydrate metabolic process is_a: GO:1900125 ! regulation of hyaluronan biosynthetic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0030213 ! positively regulates hyaluronan biosynthetic process relationship: RO:0002213 GO:0030213 ! positively regulates hyaluronan biosynthetic process creation_date: 2012-02-23T01:09:33Z [Term] id: GO:1900131 name: negative regulation of lipid binding namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of lipid binding." [GOC:pm, GOC:TermGenie] subset: gocheck_do_not_annotate synonym: "down regulation of lipid binding" EXACT [GOC:TermGenie] synonym: "down-regulation of lipid binding" EXACT [GOC:TermGenie] synonym: "downregulation of lipid binding" EXACT [GOC:TermGenie] synonym: "inhibition of lipid binding" NARROW [GOC:TermGenie] is_a: GO:0051100 ! negative regulation of binding intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0008289 ! negatively regulates lipid binding relationship: RO:0002212 GO:0008289 ! negatively regulates lipid binding creation_date: 2012-02-23T04:05:07Z [Term] id: GO:1900133 name: regulation of renin secretion into blood stream namespace: biological_process def: "Any process that modulates the frequency, rate or extent of renin secretion into blood stream." [GOC:TermGenie] synonym: "regulation of renin release into blood stream" EXACT [GOC:TermGenie] is_a: GO:0003073 ! regulation of systemic arterial blood pressure is_a: GO:0044060 ! regulation of endocrine process is_a: GO:0050708 ! regulation of protein secretion is_a: GO:0098801 ! regulation of renal system process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0002001 ! regulates renin secretion into blood stream relationship: RO:0002211 GO:0002001 ! regulates renin secretion into blood stream property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 creation_date: 2012-02-27T10:32:01Z [Term] id: GO:1900134 name: negative regulation of renin secretion into blood stream namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of renin secretion into blood stream." [GOC:TermGenie] synonym: "down regulation of renin release into blood stream" EXACT [GOC:TermGenie] synonym: "down regulation of renin secretion into blood stream" EXACT [GOC:TermGenie] synonym: "down-regulation of renin release into blood stream" EXACT [GOC:TermGenie] synonym: "down-regulation of renin secretion into blood stream" EXACT [GOC:TermGenie] synonym: "downregulation of renin release into blood stream" EXACT [GOC:TermGenie] synonym: "downregulation of renin secretion into blood stream" EXACT [GOC:TermGenie] synonym: "inhibition of renin release into blood stream" NARROW [GOC:TermGenie] synonym: "inhibition of renin secretion into blood stream" NARROW [GOC:TermGenie] synonym: "negative regulation of renin release into blood stream" EXACT [GOC:TermGenie] is_a: GO:0050709 ! negative regulation of protein secretion is_a: GO:1900133 ! regulation of renin secretion into blood stream intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0002001 ! negatively regulates renin secretion into blood stream relationship: RO:0002212 GO:0002001 ! negatively regulates renin secretion into blood stream property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 creation_date: 2012-02-27T10:32:05Z [Term] id: GO:1900135 name: positive regulation of renin secretion into blood stream namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of renin secretion into blood stream." [GOC:TermGenie] synonym: "activation of renin release into blood stream" NARROW [GOC:TermGenie] synonym: "activation of renin secretion into blood stream" NARROW [GOC:TermGenie] synonym: "positive regulation of renin release into blood stream" EXACT [GOC:TermGenie] synonym: "up regulation of renin release into blood stream" EXACT [GOC:TermGenie] synonym: "up regulation of renin secretion into blood stream" EXACT [GOC:TermGenie] synonym: "up-regulation of renin release into blood stream" EXACT [GOC:TermGenie] synonym: "up-regulation of renin secretion into blood stream" EXACT [GOC:TermGenie] synonym: "upregulation of renin release into blood stream" EXACT [GOC:TermGenie] synonym: "upregulation of renin secretion into blood stream" EXACT [GOC:TermGenie] is_a: GO:0050714 ! positive regulation of protein secretion is_a: GO:1900133 ! regulation of renin secretion into blood stream intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0002001 ! positively regulates renin secretion into blood stream relationship: RO:0002213 GO:0002001 ! positively regulates renin secretion into blood stream property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 creation_date: 2012-02-27T10:32:08Z [Term] id: GO:1900141 name: regulation of oligodendrocyte apoptotic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of oligodendrocyte apoptotic process." [GOC:TermGenie, GOC:yaf] synonym: "regulation of oligodendrocyte apoptosis" NARROW [GOC:TermGenie] is_a: GO:0034350 ! regulation of glial cell apoptotic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0097252 ! regulates oligodendrocyte apoptotic process relationship: RO:0002211 GO:0097252 ! regulates oligodendrocyte apoptotic process property_value: RO:0002161 NCBITaxon:4896 creation_date: 2012-03-06T10:22:45Z [Term] id: GO:1900142 name: negative regulation of oligodendrocyte apoptotic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of oligodendrocyte apoptotic process." [GOC:TermGenie, GOC:yaf] synonym: "down regulation of oligodendrocyte apoptosis" NARROW [GOC:TermGenie] synonym: "down regulation of oligodendrocyte apoptotic process" EXACT [GOC:TermGenie] synonym: "down-regulation of oligodendrocyte apoptosis" NARROW [GOC:TermGenie] synonym: "down-regulation of oligodendrocyte apoptotic process" EXACT [GOC:TermGenie] synonym: "downregulation of oligodendrocyte apoptosis" NARROW [GOC:TermGenie] synonym: "downregulation of oligodendrocyte apoptotic process" EXACT [GOC:TermGenie] synonym: "inhibition of oligodendrocyte apoptosis" NARROW [GOC:TermGenie] synonym: "inhibition of oligodendrocyte apoptotic process" NARROW [GOC:TermGenie] synonym: "negative regulation of oligodendrocyte apoptosis" NARROW [GOC:TermGenie] is_a: GO:0034351 ! negative regulation of glial cell apoptotic process is_a: GO:1900141 ! regulation of oligodendrocyte apoptotic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0097252 ! negatively regulates oligodendrocyte apoptotic process relationship: RO:0002212 GO:0097252 ! negatively regulates oligodendrocyte apoptotic process property_value: RO:0002161 NCBITaxon:4896 creation_date: 2012-03-06T10:22:50Z [Term] id: GO:1900143 name: positive regulation of oligodendrocyte apoptotic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of oligodendrocyte apoptotic process." [GOC:TermGenie, GOC:yaf] synonym: "activation of oligodendrocyte apoptosis" NARROW [GOC:TermGenie] synonym: "activation of oligodendrocyte apoptotic process" NARROW [GOC:TermGenie] synonym: "positive regulation of oligodendrocyte apoptosis" NARROW [GOC:TermGenie] synonym: "up regulation of oligodendrocyte apoptosis" NARROW [GOC:TermGenie] synonym: "up regulation of oligodendrocyte apoptotic process" EXACT [GOC:TermGenie] synonym: "up-regulation of oligodendrocyte apoptosis" NARROW [GOC:TermGenie] synonym: "up-regulation of oligodendrocyte apoptotic process" EXACT [GOC:TermGenie] synonym: "upregulation of oligodendrocyte apoptosis" NARROW [GOC:TermGenie] synonym: "upregulation of oligodendrocyte apoptotic process" EXACT [GOC:TermGenie] is_a: GO:0034352 ! positive regulation of glial cell apoptotic process is_a: GO:1900141 ! regulation of oligodendrocyte apoptotic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0097252 ! positively regulates oligodendrocyte apoptotic process relationship: RO:0002213 GO:0097252 ! positively regulates oligodendrocyte apoptotic process property_value: RO:0002161 NCBITaxon:4896 creation_date: 2012-03-06T10:22:54Z [Term] id: GO:1900147 name: regulation of Schwann cell migration namespace: biological_process def: "Any process that modulates the frequency, rate or extent of Schwann cell migration." [GOC:sjw, GOC:TermGenie] is_a: GO:1903975 ! regulation of glial cell migration intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0036135 ! regulates Schwann cell migration relationship: RO:0002211 GO:0036135 ! regulates Schwann cell migration creation_date: 2012-03-06T04:14:50Z [Term] id: GO:1900148 name: negative regulation of Schwann cell migration namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of Schwann cell migration." [GOC:sjw, GOC:TermGenie] synonym: "down regulation of Schwann cell migration" EXACT [GOC:TermGenie] synonym: "down-regulation of Schwann cell migration" EXACT [GOC:TermGenie] synonym: "downregulation of Schwann cell migration" EXACT [GOC:TermGenie] synonym: "inhibition of Schwann cell migration" NARROW [GOC:TermGenie] is_a: GO:1900147 ! regulation of Schwann cell migration is_a: GO:1903976 ! negative regulation of glial cell migration intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0036135 ! negatively regulates Schwann cell migration relationship: RO:0002212 GO:0036135 ! negatively regulates Schwann cell migration creation_date: 2012-03-06T04:14:55Z [Term] id: GO:1900149 name: positive regulation of Schwann cell migration namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of Schwann cell migration." [GOC:sjw, GOC:TermGenie] synonym: "activation of Schwann cell migration" NARROW [GOC:TermGenie] synonym: "up regulation of Schwann cell migration" EXACT [GOC:TermGenie] synonym: "up-regulation of Schwann cell migration" EXACT [GOC:TermGenie] synonym: "upregulation of Schwann cell migration" EXACT [GOC:TermGenie] is_a: GO:1900147 ! regulation of Schwann cell migration is_a: GO:1903977 ! positive regulation of glial cell migration intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0036135 ! positively regulates Schwann cell migration relationship: RO:0002213 GO:0036135 ! positively regulates Schwann cell migration creation_date: 2012-03-06T04:14:58Z [Term] id: GO:1900150 name: regulation of defense response to fungus namespace: biological_process def: "Any process that modulates the frequency, rate or extent of defense response to fungus." [GOC:dhl, GOC:TermGenie, PMID:22242006] synonym: "regulation of defence response to fungi" EXACT [GOC:TermGenie] synonym: "regulation of defence response to fungus" EXACT [GOC:TermGenie] synonym: "regulation of defense response to fungi" EXACT [GOC:TermGenie] synonym: "regulation of defense response to fungi, incompatible interaction" NARROW [GOC:obol] synonym: "regulation of defense response to fungus, incompatible interaction" NARROW [] synonym: "regulation of resistance response to pathogenic fungi" NARROW [GOC:obol] synonym: "regulation of resistance response to pathogenic fungus" NARROW [GOC:obol] synonym: "regulation of response to pathogenic fungus (incompatible interaction)" NARROW [GOC:obol] is_a: GO:0002831 ! regulation of response to biotic stimulus is_a: GO:0031347 ! regulation of defense response is_a: GO:0032101 ! regulation of response to external stimulus intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0050832 ! regulates defense response to fungus relationship: RO:0002211 GO:0050832 ! regulates defense response to fungus property_value: RO:0002161 NCBITaxon:4895 creation_date: 2012-03-06T10:00:16Z [Term] id: GO:1900157 name: regulation of bone mineralization involved in bone maturation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of bone mineralization involved in bone maturation." [GOC:BHF, GOC:TermGenie] is_a: GO:0030500 ! regulation of bone mineralization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0035630 ! regulates bone mineralization involved in bone maturation relationship: RO:0002211 GO:0035630 ! regulates bone mineralization involved in bone maturation creation_date: 2012-03-07T08:55:07Z [Term] id: GO:1900158 name: negative regulation of bone mineralization involved in bone maturation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of bone mineralization involved in bone maturation." [GOC:BHF, GOC:TermGenie] synonym: "down regulation of bone mineralization involved in bone maturation" EXACT [GOC:TermGenie] synonym: "down-regulation of bone mineralization involved in bone maturation" EXACT [GOC:TermGenie] synonym: "downregulation of bone mineralization involved in bone maturation" EXACT [GOC:TermGenie] synonym: "inhibition of bone mineralization involved in bone maturation" NARROW [GOC:TermGenie] is_a: GO:0030502 ! negative regulation of bone mineralization is_a: GO:1900157 ! regulation of bone mineralization involved in bone maturation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0035630 ! negatively regulates bone mineralization involved in bone maturation relationship: RO:0002212 GO:0035630 ! negatively regulates bone mineralization involved in bone maturation creation_date: 2012-03-07T08:55:12Z [Term] id: GO:1900159 name: positive regulation of bone mineralization involved in bone maturation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of bone mineralization involved in bone maturation." [GOC:BHF, GOC:TermGenie] synonym: "activation of bone mineralization involved in bone maturation" NARROW [GOC:TermGenie] synonym: "up regulation of bone mineralization involved in bone maturation" EXACT [GOC:TermGenie] synonym: "up-regulation of bone mineralization involved in bone maturation" EXACT [GOC:TermGenie] synonym: "upregulation of bone mineralization involved in bone maturation" EXACT [GOC:TermGenie] is_a: GO:0030501 ! positive regulation of bone mineralization is_a: GO:1900157 ! regulation of bone mineralization involved in bone maturation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0035630 ! positively regulates bone mineralization involved in bone maturation relationship: RO:0002213 GO:0035630 ! positively regulates bone mineralization involved in bone maturation creation_date: 2012-03-07T08:55:16Z [Term] id: GO:1900160 name: plastid chromosome packaging namespace: biological_process def: "A process in which plastidial DNA and associated proteins organize into a compact, orderly structure." [GOC:emb, GOC:TermGenie, PMID:12081370] synonym: "DNA organisation in plastid" EXACT [GOC:TermGenie] synonym: "DNA organization in plastid" EXACT [GOC:TermGenie] synonym: "plastid DNA packaging" EXACT [] synonym: "plastidial DNA packaging" EXACT [GOC:emb] is_a: GO:0051276 ! chromosome organization intersection_of: GO:0051276 ! chromosome organization intersection_of: BFO:0000066 GO:0009536 ! occurs in plastid relationship: BFO:0000066 GO:0009536 ! occurs in plastid property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:28009 property_value: RO:0002161 NCBITaxon:33208 property_value: RO:0002161 NCBITaxon:4751 property_value: RO:0002161 NCBITaxon:554915 creation_date: 2012-03-08T10:51:50Z [Term] id: GO:1900180 name: regulation of protein localization to nucleus namespace: biological_process def: "Any process that modulates the frequency, rate or extent of protein localization to nucleus." [GOC:TermGenie] synonym: "regulation of protein localisation to nucleus" EXACT [GOC:TermGenie] synonym: "regulation of protein localization in cell nucleus" EXACT [GOC:TermGenie] synonym: "regulation of protein localization in nucleus" EXACT [GOC:TermGenie] is_a: GO:0032880 ! regulation of protein localization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0034504 ! regulates protein localization to nucleus relationship: RO:0002211 GO:0034504 ! regulates protein localization to nucleus creation_date: 2012-03-12T01:23:44Z [Term] id: GO:1900181 name: negative regulation of protein localization to nucleus namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to nucleus." [GOC:TermGenie] synonym: "down regulation of protein localisation to nucleus" EXACT [GOC:TermGenie] synonym: "down regulation of protein localization in cell nucleus" EXACT [GOC:TermGenie] synonym: "down regulation of protein localization in nucleus" EXACT [GOC:TermGenie] synonym: "down regulation of protein localization to nucleus" EXACT [GOC:TermGenie] synonym: "down-regulation of protein localisation to nucleus" EXACT [GOC:TermGenie] synonym: "down-regulation of protein localization in cell nucleus" EXACT [GOC:TermGenie] synonym: "down-regulation of protein localization in nucleus" EXACT [GOC:TermGenie] synonym: "down-regulation of protein localization to nucleus" EXACT [GOC:TermGenie] synonym: "downregulation of protein localisation to nucleus" EXACT [GOC:TermGenie] synonym: "downregulation of protein localization in cell nucleus" EXACT [GOC:TermGenie] synonym: "downregulation of protein localization in nucleus" EXACT [GOC:TermGenie] synonym: "downregulation of protein localization to nucleus" EXACT [GOC:TermGenie] synonym: "inhibition of protein localisation to nucleus" NARROW [GOC:TermGenie] synonym: "inhibition of protein localization in cell nucleus" NARROW [GOC:TermGenie] synonym: "inhibition of protein localization in nucleus" NARROW [GOC:TermGenie] synonym: "inhibition of protein localization to nucleus" NARROW [GOC:TermGenie] synonym: "negative regulation of protein localisation to nucleus" EXACT [GOC:TermGenie] synonym: "negative regulation of protein localization in cell nucleus" EXACT [GOC:TermGenie] synonym: "negative regulation of protein localization in nucleus" EXACT [GOC:TermGenie] is_a: GO:1900180 ! regulation of protein localization to nucleus is_a: GO:1903828 ! negative regulation of protein localization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0034504 ! negatively regulates protein localization to nucleus relationship: RO:0002212 GO:0034504 ! negatively regulates protein localization to nucleus creation_date: 2012-03-12T01:23:48Z [Term] id: GO:1900182 name: positive regulation of protein localization to nucleus namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of protein localization to nucleus." [GOC:TermGenie] synonym: "activation of protein localisation to nucleus" NARROW [GOC:TermGenie] synonym: "activation of protein localization in cell nucleus" NARROW [GOC:TermGenie] synonym: "activation of protein localization in nucleus" EXACT [GOC:TermGenie] synonym: "activation of protein localization to nucleus" NARROW [GOC:TermGenie] synonym: "positive regulation of protein localisation to nucleus" EXACT [GOC:TermGenie] synonym: "positive regulation of protein localization in cell nucleus" EXACT [GOC:TermGenie] synonym: "positive regulation of protein localization in nucleus" EXACT [GOC:TermGenie] synonym: "up regulation of protein localisation to nucleus" EXACT [GOC:TermGenie] synonym: "up regulation of protein localization in cell nucleus" EXACT [GOC:TermGenie] synonym: "up regulation of protein localization in nucleus" EXACT [GOC:TermGenie] synonym: "up regulation of protein localization to nucleus" EXACT [GOC:TermGenie] synonym: "up-regulation of protein localisation to nucleus" EXACT [GOC:TermGenie] synonym: "up-regulation of protein localization in cell nucleus" EXACT [GOC:TermGenie] synonym: "up-regulation of protein localization in nucleus" EXACT [GOC:TermGenie] synonym: "up-regulation of protein localization to nucleus" EXACT [GOC:TermGenie] synonym: "upregulation of protein localisation to nucleus" EXACT [GOC:TermGenie] synonym: "upregulation of protein localization in cell nucleus" EXACT [GOC:TermGenie] synonym: "upregulation of protein localization in nucleus" EXACT [GOC:TermGenie] synonym: "upregulation of protein localization to nucleus" EXACT [GOC:TermGenie] is_a: GO:1900180 ! regulation of protein localization to nucleus is_a: GO:1903829 ! positive regulation of protein localization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0034504 ! positively regulates protein localization to nucleus relationship: RO:0002213 GO:0034504 ! positively regulates protein localization to nucleus creation_date: 2012-03-12T01:23:52Z [Term] id: GO:1900193 name: regulation of oocyte maturation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of oocyte maturation." [GOC:kmv, GOC:TermGenie] is_a: GO:1903429 ! regulation of cell maturation is_a: GO:2000241 ! regulation of reproductive process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0001556 ! regulates oocyte maturation relationship: RO:0002211 GO:0001556 ! regulates oocyte maturation creation_date: 2012-03-19T09:41:18Z [Term] id: GO:1900194 name: negative regulation of oocyte maturation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of oocyte maturation." [GOC:kmv, GOC:TermGenie] synonym: "down regulation of oocyte maturation" EXACT [GOC:TermGenie] synonym: "down-regulation of oocyte maturation" EXACT [GOC:TermGenie] synonym: "downregulation of oocyte maturation" EXACT [GOC:TermGenie] synonym: "inhibition of oocyte maturation" NARROW [GOC:TermGenie] is_a: GO:1900193 ! regulation of oocyte maturation is_a: GO:1903430 ! negative regulation of cell maturation is_a: GO:2000242 ! negative regulation of reproductive process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0001556 ! negatively regulates oocyte maturation relationship: RO:0002212 GO:0001556 ! negatively regulates oocyte maturation creation_date: 2012-03-19T09:41:27Z [Term] id: GO:1900195 name: positive regulation of oocyte maturation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of oocyte maturation." [GOC:kmv, GOC:TermGenie] synonym: "activation of oocyte maturation" NARROW [GOC:TermGenie] synonym: "up regulation of oocyte maturation" EXACT [GOC:TermGenie] synonym: "up-regulation of oocyte maturation" EXACT [GOC:TermGenie] synonym: "upregulation of oocyte maturation" EXACT [GOC:TermGenie] is_a: GO:1900193 ! regulation of oocyte maturation is_a: GO:1903431 ! positive regulation of cell maturation is_a: GO:2000243 ! positive regulation of reproductive process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0001556 ! positively regulates oocyte maturation relationship: RO:0002213 GO:0001556 ! positively regulates oocyte maturation creation_date: 2012-03-19T09:41:35Z [Term] id: GO:1900200 name: mesenchymal cell apoptotic process involved in metanephros development namespace: biological_process def: "Any mesenchymal cell apoptotic process that is involved in metanephros development." [GOC:mtg_apoptosis, GOC:mtg_kidney_jan10, GOC:TermGenie, GOC:yaf, PMID:17314325] synonym: "mesenchymal cell apoptosis involved in metanephros development" NARROW [] is_a: GO:0097152 ! mesenchymal cell apoptotic process is_a: GO:1902742 ! apoptotic process involved in development intersection_of: GO:0097152 ! mesenchymal cell apoptotic process intersection_of: BFO:0000050 GO:0001656 ! part of metanephros development relationship: BFO:0000050 GO:0001656 ! part of metanephros development creation_date: 2012-03-21T11:58:05Z [Term] id: GO:1900204 name: apoptotic process involved in metanephric collecting duct development namespace: biological_process def: "Any apoptotic process that is involved in metanephric collecting duct development." [GOC:mtg_kidney_jan10, GOC:TermGenie, GOC:yaf, PMID:17314325] synonym: "apoptosis of metanephric collecting duct development" NARROW [GOC:TermGenie] synonym: "apoptotic cell death of metanephric collecting duct development" EXACT [GOC:TermGenie] synonym: "apoptotic process of metanephric collecting duct development" EXACT [GOC:TermGenie] synonym: "apoptotic program of metanephric collecting duct development" NARROW [GOC:TermGenie] synonym: "apoptotic programmed cell death of metanephric collecting duct development" EXACT [GOC:TermGenie] synonym: "programmed cell death by apoptosis of metanephric collecting duct development" EXACT [GOC:TermGenie] synonym: "signaling (initiator) caspase activity of metanephric collecting duct development" RELATED [GOC:TermGenie] synonym: "type I programmed cell death of metanephric collecting duct development" NARROW [GOC:TermGenie] is_a: GO:1902742 ! apoptotic process involved in development intersection_of: GO:0006915 ! apoptotic process intersection_of: BFO:0000050 GO:0072205 ! part of metanephric collecting duct development relationship: BFO:0000050 GO:0072205 ! part of metanephric collecting duct development creation_date: 2012-03-21T01:21:32Z [Term] id: GO:1900205 name: apoptotic process involved in metanephric nephron tubule development namespace: biological_process def: "Any apoptotic process that is involved in metanephric nephron tubule development." [GOC:mtg_kidney_jan10, GOC:TermGenie, GOC:yaf, PMID:17314325] synonym: "apoptosis of metanephric nephron tubule development" NARROW [GOC:TermGenie] synonym: "apoptotic cell death of metanephric nephron tubule development" EXACT [GOC:TermGenie] synonym: "apoptotic process of metanephric nephron tubule development" EXACT [GOC:TermGenie] synonym: "apoptotic program of metanephric nephron tubule development" NARROW [GOC:TermGenie] synonym: "apoptotic programmed cell death of metanephric nephron tubule development" EXACT [GOC:TermGenie] synonym: "programmed cell death by apoptosis of metanephric nephron tubule development" EXACT [GOC:TermGenie] synonym: "signaling (initiator) caspase activity of metanephric nephron tubule development" RELATED [GOC:TermGenie] synonym: "type I programmed cell death of metanephric nephron tubule development" NARROW [GOC:TermGenie] is_a: GO:1902742 ! apoptotic process involved in development intersection_of: GO:0006915 ! apoptotic process intersection_of: BFO:0000050 GO:0072234 ! part of metanephric nephron tubule development relationship: BFO:0000050 GO:0072234 ! part of metanephric nephron tubule development creation_date: 2012-03-21T01:21:45Z [Term] id: GO:1900206 name: regulation of pronephric nephron tubule development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of pronephric nephron tubule development." [GOC:TermGenie] is_a: GO:0050793 ! regulation of developmental process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0039020 ! regulates pronephric nephron tubule development relationship: RO:0002211 GO:0039020 ! regulates pronephric nephron tubule development creation_date: 2012-03-22T09:23:13Z [Term] id: GO:1900207 name: negative regulation of pronephric nephron tubule development namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of pronephric nephron tubule development." [GOC:bf, GOC:TermGenie, PMID:9758706] synonym: "down regulation of pronephric nephron tubule development" EXACT [GOC:TermGenie] synonym: "down-regulation of pronephric nephron tubule development" EXACT [GOC:TermGenie] synonym: "downregulation of pronephric nephron tubule development" EXACT [GOC:TermGenie] synonym: "inhibition of pronephric nephron tubule development" NARROW [GOC:TermGenie] is_a: GO:0051093 ! negative regulation of developmental process is_a: GO:1900206 ! regulation of pronephric nephron tubule development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0039020 ! negatively regulates pronephric nephron tubule development relationship: RO:0002212 GO:0039020 ! negatively regulates pronephric nephron tubule development creation_date: 2012-03-22T09:23:23Z [Term] id: GO:1900211 name: regulation of mesenchymal cell apoptotic process involved in metanephros development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of mesenchymal cell apoptotic process involved in metanephros development." [GOC:mtg_apoptosis, GOC:mtg_kidney_jan10, GOC:TermGenie, GOC:yaf, PMID:17314325] synonym: "regulation of mesenchymal cell apoptosis involved in metanephros development" NARROW [] is_a: GO:1904748 ! regulation of apoptotic process involved in development is_a: GO:2001053 ! regulation of mesenchymal cell apoptotic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:1900200 ! regulates mesenchymal cell apoptotic process involved in metanephros development relationship: RO:0002211 GO:1900200 ! regulates mesenchymal cell apoptotic process involved in metanephros development creation_date: 2012-03-22T10:52:50Z [Term] id: GO:1900212 name: negative regulation of mesenchymal cell apoptotic process involved in metanephros development namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of mesenchymal cell apoptotic process involved in metanephros development." [GOC:mtg_apoptosis, GOC:mtg_kidney_jan10, GOC:TermGenie, GOC:yaf, PMID:17314325] synonym: "down regulation of mesenchymal cell apoptosis involved in metanephros development" EXACT [GOC:TermGenie] synonym: "down-regulation of mesenchymal cell apoptosis involved in metanephros development" EXACT [GOC:TermGenie] synonym: "downregulation of mesenchymal cell apoptosis involved in metanephros development" EXACT [GOC:TermGenie] synonym: "inhibition of mesenchymal cell apoptosis involved in metanephros development" NARROW [GOC:TermGenie] synonym: "negative regulation of mesenchymal cell apoptosis involved in metanephros development" NARROW [] is_a: GO:1900211 ! regulation of mesenchymal cell apoptotic process involved in metanephros development is_a: GO:1904746 ! negative regulation of apoptotic process involved in development is_a: GO:2001054 ! negative regulation of mesenchymal cell apoptotic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:1900200 ! negatively regulates mesenchymal cell apoptotic process involved in metanephros development relationship: RO:0002212 GO:1900200 ! negatively regulates mesenchymal cell apoptotic process involved in metanephros development creation_date: 2012-03-22T10:53:00Z [Term] id: GO:1900213 name: positive regulation of mesenchymal cell apoptotic process involved in metanephros development namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of mesenchymal cell apoptotic process involved in metanephros development." [GOC:mtg_apoptosis, GOC:mtg_kidney_jan10, GOC:TermGenie, GOC:yaf, PMID:17314325] synonym: "activation of mesenchymal cell apoptosis involved in metanephros development" NARROW [GOC:TermGenie] synonym: "positive regulation of mesenchymal cell apoptosis involved in metanephros development" NARROW [] synonym: "up regulation of mesenchymal cell apoptosis involved in metanephros development" EXACT [GOC:TermGenie] synonym: "up-regulation of mesenchymal cell apoptosis involved in metanephros development" EXACT [GOC:TermGenie] synonym: "upregulation of mesenchymal cell apoptosis involved in metanephros development" EXACT [GOC:TermGenie] is_a: GO:1900211 ! regulation of mesenchymal cell apoptotic process involved in metanephros development is_a: GO:1904747 ! positive regulation of apoptotic process involved in development is_a: GO:2001055 ! positive regulation of mesenchymal cell apoptotic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:1900200 ! positively regulates mesenchymal cell apoptotic process involved in metanephros development relationship: RO:0002213 GO:1900200 ! positively regulates mesenchymal cell apoptotic process involved in metanephros development creation_date: 2012-03-22T10:53:09Z [Term] id: GO:1900214 name: regulation of apoptotic process involved in metanephric collecting duct development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of apoptotic process involved in metanephric collecting duct development." [GOC:mtg_kidney_jan10, GOC:TermGenie, GOC:yaf, PMID:17314325] synonym: "regulation of apoptosis of metanephric collecting duct development" NARROW [GOC:TermGenie] synonym: "regulation of apoptotic cell death of metanephric collecting duct development" EXACT [GOC:TermGenie] synonym: "regulation of apoptotic process of metanephric collecting duct development" EXACT [GOC:TermGenie] synonym: "regulation of apoptotic program of metanephric collecting duct development" NARROW [GOC:TermGenie] synonym: "regulation of apoptotic programmed cell death of metanephric collecting duct development" EXACT [GOC:TermGenie] synonym: "regulation of programmed cell death by apoptosis of metanephric collecting duct development" EXACT [GOC:TermGenie] synonym: "regulation of signaling (initiator) caspase activity of metanephric collecting duct development" RELATED [GOC:TermGenie] synonym: "regulation of type I programmed cell death of metanephric collecting duct development" NARROW [GOC:TermGenie] is_a: GO:1904748 ! regulation of apoptotic process involved in development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:1900204 ! regulates apoptotic process involved in metanephric collecting duct development relationship: RO:0002211 GO:1900204 ! regulates apoptotic process involved in metanephric collecting duct development creation_date: 2012-03-22T10:53:21Z [Term] id: GO:1900215 name: negative regulation of apoptotic process involved in metanephric collecting duct development namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of apoptotic process involved in metanephric collecting duct development." [GOC:mtg_kidney_jan10, GOC:TermGenie, GOC:yaf, PMID:17314325] synonym: "down regulation of apoptosis of metanephric collecting duct development" NARROW [GOC:TermGenie] synonym: "down regulation of apoptotic cell death of metanephric collecting duct development" EXACT [GOC:TermGenie] synonym: "down regulation of apoptotic process involved in metanephric collecting duct development" EXACT [GOC:TermGenie] synonym: "down regulation of apoptotic process of metanephric collecting duct development" EXACT [GOC:TermGenie] synonym: "down regulation of apoptotic program of metanephric collecting duct development" NARROW [GOC:TermGenie] synonym: "down regulation of apoptotic programmed cell death of metanephric collecting duct development" EXACT [GOC:TermGenie] synonym: "down regulation of programmed cell death by apoptosis of metanephric collecting duct development" EXACT [GOC:TermGenie] synonym: "down regulation of signaling (initiator) caspase activity of metanephric collecting duct development" RELATED [GOC:TermGenie] synonym: "down regulation of type I programmed cell death of metanephric collecting duct development" NARROW [GOC:TermGenie] synonym: "down-regulation of apoptosis of metanephric collecting duct development" NARROW [GOC:TermGenie] synonym: "down-regulation of apoptotic cell death of metanephric collecting duct development" EXACT [GOC:TermGenie] synonym: "down-regulation of apoptotic process involved in metanephric collecting duct development" EXACT [GOC:TermGenie] synonym: "down-regulation of apoptotic process of metanephric collecting duct development" EXACT [GOC:TermGenie] synonym: "down-regulation of apoptotic program of metanephric collecting duct development" NARROW [GOC:TermGenie] synonym: "down-regulation of apoptotic programmed cell death of metanephric collecting duct development" EXACT [GOC:TermGenie] synonym: "down-regulation of programmed cell death by apoptosis of metanephric collecting duct development" EXACT [GOC:TermGenie] synonym: "down-regulation of signaling (initiator) caspase activity of metanephric collecting duct development" RELATED [GOC:TermGenie] synonym: "down-regulation of type I programmed cell death of metanephric collecting duct development" NARROW [GOC:TermGenie] synonym: "downregulation of apoptosis of metanephric collecting duct development" NARROW [GOC:TermGenie] synonym: "downregulation of apoptotic cell death of metanephric collecting duct development" EXACT [GOC:TermGenie] synonym: "downregulation of apoptotic process involved in metanephric collecting duct development" EXACT [GOC:TermGenie] synonym: "downregulation of apoptotic process of metanephric collecting duct development" EXACT [GOC:TermGenie] synonym: "downregulation of apoptotic program of metanephric collecting duct development" NARROW [GOC:TermGenie] synonym: "downregulation of apoptotic programmed cell death of metanephric collecting duct development" EXACT [GOC:TermGenie] synonym: "downregulation of programmed cell death by apoptosis of metanephric collecting duct development" EXACT [GOC:TermGenie] synonym: "downregulation of signaling (initiator) caspase activity of metanephric collecting duct development" RELATED [GOC:TermGenie] synonym: "downregulation of type I programmed cell death of metanephric collecting duct development" NARROW [GOC:TermGenie] synonym: "inhibition of apoptosis of metanephric collecting duct development" NARROW [GOC:TermGenie] synonym: "inhibition of apoptotic cell death of metanephric collecting duct development" EXACT [GOC:TermGenie] synonym: "inhibition of apoptotic process involved in metanephric collecting duct development" NARROW [GOC:TermGenie] synonym: "inhibition of apoptotic process of metanephric collecting duct development" EXACT [GOC:TermGenie] synonym: "inhibition of apoptotic program of metanephric collecting duct development" NARROW [GOC:TermGenie] synonym: "inhibition of apoptotic programmed cell death of metanephric collecting duct development" EXACT [GOC:TermGenie] synonym: "inhibition of programmed cell death by apoptosis of metanephric collecting duct development" EXACT [GOC:TermGenie] synonym: "inhibition of signaling (initiator) caspase activity of metanephric collecting duct development" RELATED [GOC:TermGenie] synonym: "inhibition of type I programmed cell death of metanephric collecting duct development" NARROW [GOC:TermGenie] synonym: "negative regulation of apoptosis of metanephric collecting duct development" NARROW [GOC:TermGenie] synonym: "negative regulation of apoptotic cell death of metanephric collecting duct development" EXACT [GOC:TermGenie] synonym: "negative regulation of apoptotic process of metanephric collecting duct development" EXACT [GOC:TermGenie] synonym: "negative regulation of apoptotic program of metanephric collecting duct development" NARROW [GOC:TermGenie] synonym: "negative regulation of apoptotic programmed cell death of metanephric collecting duct development" EXACT [GOC:TermGenie] synonym: "negative regulation of programmed cell death by apoptosis of metanephric collecting duct development" EXACT [GOC:TermGenie] synonym: "negative regulation of signaling (initiator) caspase activity of metanephric collecting duct development" RELATED [GOC:TermGenie] synonym: "negative regulation of type I programmed cell death of metanephric collecting duct development" NARROW [GOC:TermGenie] is_a: GO:1900214 ! regulation of apoptotic process involved in metanephric collecting duct development is_a: GO:1904746 ! negative regulation of apoptotic process involved in development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:1900204 ! negatively regulates apoptotic process involved in metanephric collecting duct development relationship: RO:0002212 GO:1900204 ! negatively regulates apoptotic process involved in metanephric collecting duct development creation_date: 2012-03-22T10:53:31Z [Term] id: GO:1900216 name: positive regulation of apoptotic process involved in metanephric collecting duct development namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of apoptotic process involved in metanephric collecting duct development." [GOC:mtg_kidney_jan10, GOC:TermGenie, GOC:yaf, PMID:17314325] synonym: "activation of apoptosis of metanephric collecting duct development" NARROW [GOC:TermGenie] synonym: "activation of apoptotic cell death of metanephric collecting duct development" EXACT [GOC:TermGenie] synonym: "activation of apoptotic process involved in metanephric collecting duct development" NARROW [GOC:TermGenie] synonym: "activation of apoptotic process of metanephric collecting duct development" EXACT [GOC:TermGenie] synonym: "activation of apoptotic program of metanephric collecting duct development" NARROW [GOC:TermGenie] synonym: "activation of apoptotic programmed cell death of metanephric collecting duct development" EXACT [GOC:TermGenie] synonym: "activation of programmed cell death by apoptosis of metanephric collecting duct development" EXACT [GOC:TermGenie] synonym: "activation of signaling (initiator) caspase activity of metanephric collecting duct development" RELATED [GOC:TermGenie] synonym: "activation of type I programmed cell death of metanephric collecting duct development" NARROW [GOC:TermGenie] synonym: "positive regulation of apoptosis of metanephric collecting duct development" NARROW [GOC:TermGenie] synonym: "positive regulation of apoptotic cell death of metanephric collecting duct development" EXACT [GOC:TermGenie] synonym: "positive regulation of apoptotic process of metanephric collecting duct development" EXACT [GOC:TermGenie] synonym: "positive regulation of apoptotic program of metanephric collecting duct development" NARROW [GOC:TermGenie] synonym: "positive regulation of apoptotic programmed cell death of metanephric collecting duct development" EXACT [GOC:TermGenie] synonym: "positive regulation of programmed cell death by apoptosis of metanephric collecting duct development" EXACT [GOC:TermGenie] synonym: "positive regulation of signaling (initiator) caspase activity of metanephric collecting duct development" RELATED [GOC:TermGenie] synonym: "positive regulation of type I programmed cell death of metanephric collecting duct development" NARROW [GOC:TermGenie] synonym: "up regulation of apoptosis of metanephric collecting duct development" NARROW [GOC:TermGenie] synonym: "up regulation of apoptotic cell death of metanephric collecting duct development" EXACT [GOC:TermGenie] synonym: "up regulation of apoptotic process involved in metanephric collecting duct development" EXACT [GOC:TermGenie] synonym: "up regulation of apoptotic process of metanephric collecting duct development" EXACT [GOC:TermGenie] synonym: "up regulation of apoptotic program of metanephric collecting duct development" NARROW [GOC:TermGenie] synonym: "up regulation of apoptotic programmed cell death of metanephric collecting duct development" EXACT [GOC:TermGenie] synonym: "up regulation of programmed cell death by apoptosis of metanephric collecting duct development" EXACT [GOC:TermGenie] synonym: "up regulation of signaling (initiator) caspase activity of metanephric collecting duct development" RELATED [GOC:TermGenie] synonym: "up regulation of type I programmed cell death of metanephric collecting duct development" NARROW [GOC:TermGenie] synonym: "up-regulation of apoptosis of metanephric collecting duct development" NARROW [GOC:TermGenie] synonym: "up-regulation of apoptotic cell death of metanephric collecting duct development" EXACT [GOC:TermGenie] synonym: "up-regulation of apoptotic process involved in metanephric collecting duct development" EXACT [GOC:TermGenie] synonym: "up-regulation of apoptotic process of metanephric collecting duct development" EXACT [GOC:TermGenie] synonym: "up-regulation of apoptotic program of metanephric collecting duct development" NARROW [GOC:TermGenie] synonym: "up-regulation of apoptotic programmed cell death of metanephric collecting duct development" EXACT [GOC:TermGenie] synonym: "up-regulation of programmed cell death by apoptosis of metanephric collecting duct development" EXACT [GOC:TermGenie] synonym: "up-regulation of signaling (initiator) caspase activity of metanephric collecting duct development" RELATED [GOC:TermGenie] synonym: "up-regulation of type I programmed cell death of metanephric collecting duct development" NARROW [GOC:TermGenie] synonym: "upregulation of apoptosis of metanephric collecting duct development" NARROW [GOC:TermGenie] synonym: "upregulation of apoptotic cell death of metanephric collecting duct development" EXACT [GOC:TermGenie] synonym: "upregulation of apoptotic process involved in metanephric collecting duct development" EXACT [GOC:TermGenie] synonym: "upregulation of apoptotic process of metanephric collecting duct development" EXACT [GOC:TermGenie] synonym: "upregulation of apoptotic program of metanephric collecting duct development" NARROW [GOC:TermGenie] synonym: "upregulation of apoptotic programmed cell death of metanephric collecting duct development" EXACT [GOC:TermGenie] synonym: "upregulation of programmed cell death by apoptosis of metanephric collecting duct development" EXACT [GOC:TermGenie] synonym: "upregulation of signaling (initiator) caspase activity of metanephric collecting duct development" RELATED [GOC:TermGenie] synonym: "upregulation of type I programmed cell death of metanephric collecting duct development" NARROW [GOC:TermGenie] is_a: GO:1900214 ! regulation of apoptotic process involved in metanephric collecting duct development is_a: GO:1904747 ! positive regulation of apoptotic process involved in development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:1900204 ! positively regulates apoptotic process involved in metanephric collecting duct development relationship: RO:0002213 GO:1900204 ! positively regulates apoptotic process involved in metanephric collecting duct development creation_date: 2012-03-22T10:53:39Z [Term] id: GO:1900217 name: regulation of apoptotic process involved in metanephric nephron tubule development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of apoptotic process involved in metanephric nephron tubule development." [GOC:mtg_kidney_jan10, GOC:TermGenie, GOC:yaf, PMID:17314325] synonym: "regulation of apoptosis of metanephric nephron tubule development" NARROW [GOC:TermGenie] synonym: "regulation of apoptotic cell death of metanephric nephron tubule development" EXACT [GOC:TermGenie] synonym: "regulation of apoptotic process of metanephric nephron tubule development" EXACT [GOC:TermGenie] synonym: "regulation of apoptotic program of metanephric nephron tubule development" NARROW [GOC:TermGenie] synonym: "regulation of apoptotic programmed cell death of metanephric nephron tubule development" EXACT [GOC:TermGenie] synonym: "regulation of programmed cell death by apoptosis of metanephric nephron tubule development" EXACT [GOC:TermGenie] synonym: "regulation of signaling (initiator) caspase activity of metanephric nephron tubule development" RELATED [GOC:TermGenie] synonym: "regulation of type I programmed cell death of metanephric nephron tubule development" NARROW [GOC:TermGenie] is_a: GO:1904748 ! regulation of apoptotic process involved in development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:1900205 ! regulates apoptotic process involved in metanephric nephron tubule development relationship: RO:0002211 GO:1900205 ! regulates apoptotic process involved in metanephric nephron tubule development creation_date: 2012-03-22T10:53:51Z [Term] id: GO:1900218 name: negative regulation of apoptotic process involved in metanephric nephron tubule development namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of apoptotic process involved in metanephric nephron tubule development." [GOC:mtg_kidney_jan10, GOC:TermGenie, GOC:yaf, PMID:17314325] synonym: "down regulation of apoptosis of metanephric nephron tubule development" NARROW [GOC:TermGenie] synonym: "down regulation of apoptotic cell death of metanephric nephron tubule development" EXACT [GOC:TermGenie] synonym: "down regulation of apoptotic process involved in metanephric nephron tubule development" EXACT [GOC:TermGenie] synonym: "down regulation of apoptotic process of metanephric nephron tubule development" EXACT [GOC:TermGenie] synonym: "down regulation of apoptotic program of metanephric nephron tubule development" NARROW [GOC:TermGenie] synonym: "down regulation of apoptotic programmed cell death of metanephric nephron tubule development" EXACT [GOC:TermGenie] synonym: "down regulation of programmed cell death by apoptosis of metanephric nephron tubule development" EXACT [GOC:TermGenie] synonym: "down regulation of signaling (initiator) caspase activity of metanephric nephron tubule development" RELATED [GOC:TermGenie] synonym: "down regulation of type I programmed cell death of metanephric nephron tubule development" NARROW [GOC:TermGenie] synonym: "down-regulation of apoptosis of metanephric nephron tubule development" NARROW [GOC:TermGenie] synonym: "down-regulation of apoptotic cell death of metanephric nephron tubule development" EXACT [GOC:TermGenie] synonym: "down-regulation of apoptotic process involved in metanephric nephron tubule development" EXACT [GOC:TermGenie] synonym: "down-regulation of apoptotic process of metanephric nephron tubule development" EXACT [GOC:TermGenie] synonym: "down-regulation of apoptotic program of metanephric nephron tubule development" NARROW [GOC:TermGenie] synonym: "down-regulation of apoptotic programmed cell death of metanephric nephron tubule development" EXACT [GOC:TermGenie] synonym: "down-regulation of programmed cell death by apoptosis of metanephric nephron tubule development" EXACT [GOC:TermGenie] synonym: "down-regulation of signaling (initiator) caspase activity of metanephric nephron tubule development" RELATED [GOC:TermGenie] synonym: "down-regulation of type I programmed cell death of metanephric nephron tubule development" NARROW [GOC:TermGenie] synonym: "downregulation of apoptosis of metanephric nephron tubule development" NARROW [GOC:TermGenie] synonym: "downregulation of apoptotic cell death of metanephric nephron tubule development" EXACT [GOC:TermGenie] synonym: "downregulation of apoptotic process involved in metanephric nephron tubule development" EXACT [GOC:TermGenie] synonym: "downregulation of apoptotic process of metanephric nephron tubule development" EXACT [GOC:TermGenie] synonym: "downregulation of apoptotic program of metanephric nephron tubule development" NARROW [GOC:TermGenie] synonym: "downregulation of apoptotic programmed cell death of metanephric nephron tubule development" EXACT [GOC:TermGenie] synonym: "downregulation of programmed cell death by apoptosis of metanephric nephron tubule development" EXACT [GOC:TermGenie] synonym: "downregulation of signaling (initiator) caspase activity of metanephric nephron tubule development" RELATED [GOC:TermGenie] synonym: "downregulation of type I programmed cell death of metanephric nephron tubule development" NARROW [GOC:TermGenie] synonym: "inhibition of apoptosis of metanephric nephron tubule development" NARROW [GOC:TermGenie] synonym: "inhibition of apoptotic cell death of metanephric nephron tubule development" EXACT [GOC:TermGenie] synonym: "inhibition of apoptotic process involved in metanephric nephron tubule development" NARROW [GOC:TermGenie] synonym: "inhibition of apoptotic process of metanephric nephron tubule development" EXACT [GOC:TermGenie] synonym: "inhibition of apoptotic program of metanephric nephron tubule development" NARROW [GOC:TermGenie] synonym: "inhibition of apoptotic programmed cell death of metanephric nephron tubule development" EXACT [GOC:TermGenie] synonym: "inhibition of programmed cell death by apoptosis of metanephric nephron tubule development" EXACT [GOC:TermGenie] synonym: "inhibition of signaling (initiator) caspase activity of metanephric nephron tubule development" RELATED [GOC:TermGenie] synonym: "inhibition of type I programmed cell death of metanephric nephron tubule development" NARROW [GOC:TermGenie] synonym: "negative regulation of apoptosis of metanephric nephron tubule development" NARROW [GOC:TermGenie] synonym: "negative regulation of apoptotic cell death of metanephric nephron tubule development" EXACT [GOC:TermGenie] synonym: "negative regulation of apoptotic process of metanephric nephron tubule development" EXACT [GOC:TermGenie] synonym: "negative regulation of apoptotic program of metanephric nephron tubule development" NARROW [GOC:TermGenie] synonym: "negative regulation of apoptotic programmed cell death of metanephric nephron tubule development" EXACT [GOC:TermGenie] synonym: "negative regulation of programmed cell death by apoptosis of metanephric nephron tubule development" EXACT [GOC:TermGenie] synonym: "negative regulation of signaling (initiator) caspase activity of metanephric nephron tubule development" RELATED [GOC:TermGenie] synonym: "negative regulation of type I programmed cell death of metanephric nephron tubule development" NARROW [GOC:TermGenie] is_a: GO:1900217 ! regulation of apoptotic process involved in metanephric nephron tubule development is_a: GO:1904746 ! negative regulation of apoptotic process involved in development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:1900205 ! negatively regulates apoptotic process involved in metanephric nephron tubule development relationship: RO:0002212 GO:1900205 ! negatively regulates apoptotic process involved in metanephric nephron tubule development creation_date: 2012-03-22T10:54:01Z [Term] id: GO:1900219 name: positive regulation of apoptotic process involved in metanephric nephron tubule development namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of apoptotic process involved in metanephric nephron tubule development." [GOC:mtg_kidney_jan10, GOC:TermGenie, GOC:yaf, PMID:17314325] synonym: "activation of apoptosis of metanephric nephron tubule development" NARROW [GOC:TermGenie] synonym: "activation of apoptotic cell death of metanephric nephron tubule development" EXACT [GOC:TermGenie] synonym: "activation of apoptotic process involved in metanephric nephron tubule development" NARROW [GOC:TermGenie] synonym: "activation of apoptotic process of metanephric nephron tubule development" EXACT [GOC:TermGenie] synonym: "activation of apoptotic program of metanephric nephron tubule development" NARROW [GOC:TermGenie] synonym: "activation of apoptotic programmed cell death of metanephric nephron tubule development" EXACT [GOC:TermGenie] synonym: "activation of programmed cell death by apoptosis of metanephric nephron tubule development" EXACT [GOC:TermGenie] synonym: "activation of signaling (initiator) caspase activity of metanephric nephron tubule development" RELATED [GOC:TermGenie] synonym: "activation of type I programmed cell death of metanephric nephron tubule development" NARROW [GOC:TermGenie] synonym: "positive regulation of apoptosis of metanephric nephron tubule development" NARROW [GOC:TermGenie] synonym: "positive regulation of apoptotic cell death of metanephric nephron tubule development" EXACT [GOC:TermGenie] synonym: "positive regulation of apoptotic process of metanephric nephron tubule development" EXACT [GOC:TermGenie] synonym: "positive regulation of apoptotic program of metanephric nephron tubule development" NARROW [GOC:TermGenie] synonym: "positive regulation of apoptotic programmed cell death of metanephric nephron tubule development" EXACT [GOC:TermGenie] synonym: "positive regulation of programmed cell death by apoptosis of metanephric nephron tubule development" EXACT [GOC:TermGenie] synonym: "positive regulation of signaling (initiator) caspase activity of metanephric nephron tubule development" RELATED [GOC:TermGenie] synonym: "positive regulation of type I programmed cell death of metanephric nephron tubule development" NARROW [GOC:TermGenie] synonym: "up regulation of apoptosis of metanephric nephron tubule development" NARROW [GOC:TermGenie] synonym: "up regulation of apoptotic cell death of metanephric nephron tubule development" EXACT [GOC:TermGenie] synonym: "up regulation of apoptotic process involved in metanephric nephron tubule development" EXACT [GOC:TermGenie] synonym: "up regulation of apoptotic process of metanephric nephron tubule development" EXACT [GOC:TermGenie] synonym: "up regulation of apoptotic program of metanephric nephron tubule development" NARROW [GOC:TermGenie] synonym: "up regulation of apoptotic programmed cell death of metanephric nephron tubule development" EXACT [GOC:TermGenie] synonym: "up regulation of programmed cell death by apoptosis of metanephric nephron tubule development" EXACT [GOC:TermGenie] synonym: "up regulation of signaling (initiator) caspase activity of metanephric nephron tubule development" RELATED [GOC:TermGenie] synonym: "up regulation of type I programmed cell death of metanephric nephron tubule development" NARROW [GOC:TermGenie] synonym: "up-regulation of apoptosis of metanephric nephron tubule development" NARROW [GOC:TermGenie] synonym: "up-regulation of apoptotic cell death of metanephric nephron tubule development" EXACT [GOC:TermGenie] synonym: "up-regulation of apoptotic process involved in metanephric nephron tubule development" EXACT [GOC:TermGenie] synonym: "up-regulation of apoptotic process of metanephric nephron tubule development" EXACT [GOC:TermGenie] synonym: "up-regulation of apoptotic program of metanephric nephron tubule development" NARROW [GOC:TermGenie] synonym: "up-regulation of apoptotic programmed cell death of metanephric nephron tubule development" EXACT [GOC:TermGenie] synonym: "up-regulation of programmed cell death by apoptosis of metanephric nephron tubule development" EXACT [GOC:TermGenie] synonym: "up-regulation of signaling (initiator) caspase activity of metanephric nephron tubule development" RELATED [GOC:TermGenie] synonym: "up-regulation of type I programmed cell death of metanephric nephron tubule development" NARROW [GOC:TermGenie] synonym: "upregulation of apoptosis of metanephric nephron tubule development" NARROW [GOC:TermGenie] synonym: "upregulation of apoptotic cell death of metanephric nephron tubule development" EXACT [GOC:TermGenie] synonym: "upregulation of apoptotic process involved in metanephric nephron tubule development" EXACT [GOC:TermGenie] synonym: "upregulation of apoptotic process of metanephric nephron tubule development" EXACT [GOC:TermGenie] synonym: "upregulation of apoptotic program of metanephric nephron tubule development" NARROW [GOC:TermGenie] synonym: "upregulation of apoptotic programmed cell death of metanephric nephron tubule development" EXACT [GOC:TermGenie] synonym: "upregulation of programmed cell death by apoptosis of metanephric nephron tubule development" EXACT [GOC:TermGenie] synonym: "upregulation of signaling (initiator) caspase activity of metanephric nephron tubule development" RELATED [GOC:TermGenie] synonym: "upregulation of type I programmed cell death of metanephric nephron tubule development" NARROW [GOC:TermGenie] is_a: GO:1900217 ! regulation of apoptotic process involved in metanephric nephron tubule development is_a: GO:1904747 ! positive regulation of apoptotic process involved in development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:1900205 ! positively regulates apoptotic process involved in metanephric nephron tubule development relationship: RO:0002213 GO:1900205 ! positively regulates apoptotic process involved in metanephric nephron tubule development creation_date: 2012-03-22T10:54:09Z [Term] id: GO:1900247 name: regulation of cytoplasmic translational elongation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cytoplasmic translational elongation." [GOC:TermGenie] is_a: GO:0006448 ! regulation of translational elongation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0002182 ! regulates cytoplasmic translational elongation relationship: RO:0002211 GO:0002182 ! regulates cytoplasmic translational elongation creation_date: 2012-04-03T05:07:02Z [Term] id: GO:1900248 name: negative regulation of cytoplasmic translational elongation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of cytoplasmic translational elongation." [GOC:TermGenie] synonym: "down regulation of cytoplasmic translational elongation" EXACT [GOC:TermGenie] synonym: "down-regulation of cytoplasmic translational elongation" EXACT [GOC:TermGenie] synonym: "downregulation of cytoplasmic translational elongation" EXACT [GOC:TermGenie] synonym: "inhibition of cytoplasmic translational elongation" NARROW [GOC:TermGenie] is_a: GO:0045900 ! negative regulation of translational elongation is_a: GO:1900247 ! regulation of cytoplasmic translational elongation is_a: GO:2000766 ! negative regulation of cytoplasmic translation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0002182 ! negatively regulates cytoplasmic translational elongation relationship: RO:0002212 GO:0002182 ! negatively regulates cytoplasmic translational elongation creation_date: 2012-04-03T05:07:14Z [Term] id: GO:1900249 name: positive regulation of cytoplasmic translational elongation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cytoplasmic translational elongation." [GOC:TermGenie] synonym: "activation of cytoplasmic translational elongation" NARROW [GOC:TermGenie] synonym: "up regulation of cytoplasmic translational elongation" EXACT [GOC:TermGenie] synonym: "up-regulation of cytoplasmic translational elongation" EXACT [GOC:TermGenie] synonym: "upregulation of cytoplasmic translational elongation" EXACT [GOC:TermGenie] is_a: GO:0045901 ! positive regulation of translational elongation is_a: GO:1900247 ! regulation of cytoplasmic translational elongation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0002182 ! positively regulates cytoplasmic translational elongation relationship: RO:0002213 GO:0002182 ! positively regulates cytoplasmic translational elongation creation_date: 2012-04-03T05:07:24Z [Term] id: GO:1900366 name: negative regulation of defense response to insect namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of defense response to insect." [GOC:TermGenie, PMID:22474183] synonym: "down regulation of defense response to insect" EXACT [GOC:TermGenie] synonym: "down regulation of physiological defense response to insect" EXACT [GOC:TermGenie] synonym: "down-regulation of defense response to insect" EXACT [GOC:TermGenie] synonym: "down-regulation of physiological defense response to insect" EXACT [GOC:TermGenie] synonym: "downregulation of defense response to insect" EXACT [GOC:TermGenie] synonym: "downregulation of physiological defense response to insect" EXACT [GOC:TermGenie] synonym: "inhibition of defense response to insect" NARROW [GOC:TermGenie] synonym: "inhibition of physiological defense response to insect" NARROW [GOC:TermGenie] synonym: "negative regulation of physiological defense response to insect" EXACT [GOC:TermGenie] synonym: "susceptibility to insect" RELATED [] is_a: GO:0002832 ! negative regulation of response to biotic stimulus is_a: GO:0031348 ! negative regulation of defense response is_a: GO:0032102 ! negative regulation of response to external stimulus is_a: GO:2000068 ! regulation of defense response to insect intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0002213 ! negatively regulates defense response to insect relationship: RO:0002212 GO:0002213 ! negatively regulates defense response to insect property_value: RO:0002161 NCBITaxon:4895 creation_date: 2012-04-12T04:44:00Z [Term] id: GO:1900367 name: positive regulation of defense response to insect namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of defense response to insect." [GOC:TermGenie, PMID:22474183] synonym: "activation of defense response to insect" NARROW [GOC:TermGenie] synonym: "activation of physiological defense response to insect" NARROW [GOC:TermGenie] synonym: "positive regulation of physiological defense response to insect" EXACT [GOC:TermGenie] synonym: "up regulation of defense response to insect" EXACT [GOC:TermGenie] synonym: "up regulation of physiological defense response to insect" EXACT [GOC:TermGenie] synonym: "up-regulation of defense response to insect" EXACT [GOC:TermGenie] synonym: "up-regulation of physiological defense response to insect" EXACT [GOC:TermGenie] synonym: "upregulation of defense response to insect" EXACT [GOC:TermGenie] synonym: "upregulation of physiological defense response to insect" EXACT [GOC:TermGenie] is_a: GO:0002833 ! positive regulation of response to biotic stimulus is_a: GO:0031349 ! positive regulation of defense response is_a: GO:0032103 ! positive regulation of response to external stimulus is_a: GO:2000068 ! regulation of defense response to insect intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0002213 ! positively regulates defense response to insect relationship: RO:0002213 GO:0002213 ! positively regulates defense response to insect property_value: RO:0002161 NCBITaxon:4895 creation_date: 2012-04-12T04:44:10Z [Term] id: GO:1900371 name: regulation of purine nucleotide biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of purine nucleotide biosynthetic processes." [GOC:go_curators, GOC:TermGenie] synonym: "regulation of purine nucleotide anabolism" EXACT [GOC:TermGenie] synonym: "regulation of purine nucleotide biosynthesis" EXACT [GOC:TermGenie] synonym: "regulation of purine nucleotide formation" EXACT [GOC:TermGenie] synonym: "regulation of purine nucleotide synthesis" EXACT [GOC:TermGenie] is_a: GO:0030808 ! regulation of nucleotide biosynthetic process is_a: GO:1900542 ! regulation of purine nucleotide metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0006164 ! regulates purine nucleotide biosynthetic process relationship: RO:0002211 GO:0006164 ! regulates purine nucleotide biosynthetic process creation_date: 2012-04-17T12:32:07Z [Term] id: GO:1900372 name: negative regulation of purine nucleotide biosynthetic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of purine nucleotide biosynthetic processes." [GOC:go_curators, GOC:TermGenie] synonym: "down regulation of purine nucleotide anabolism" EXACT [GOC:TermGenie] synonym: "down regulation of purine nucleotide biosynthesis" EXACT [GOC:TermGenie] synonym: "down regulation of purine nucleotide biosynthetic process" EXACT [GOC:TermGenie] synonym: "down regulation of purine nucleotide formation" EXACT [GOC:TermGenie] synonym: "down regulation of purine nucleotide synthesis" EXACT [GOC:TermGenie] synonym: "down-regulation of purine nucleotide anabolism" EXACT [GOC:TermGenie] synonym: "down-regulation of purine nucleotide biosynthesis" EXACT [GOC:TermGenie] synonym: "down-regulation of purine nucleotide biosynthetic process" EXACT [GOC:TermGenie] synonym: "down-regulation of purine nucleotide formation" EXACT [GOC:TermGenie] synonym: "down-regulation of purine nucleotide synthesis" EXACT [GOC:TermGenie] synonym: "downregulation of purine nucleotide anabolism" EXACT [GOC:TermGenie] synonym: "downregulation of purine nucleotide biosynthesis" EXACT [GOC:TermGenie] synonym: "downregulation of purine nucleotide biosynthetic process" EXACT [GOC:TermGenie] synonym: "downregulation of purine nucleotide formation" EXACT [GOC:TermGenie] synonym: "downregulation of purine nucleotide synthesis" EXACT [GOC:TermGenie] synonym: "inhibition of purine nucleotide anabolism" EXACT [GOC:TermGenie] synonym: "inhibition of purine nucleotide biosynthesis" EXACT [GOC:TermGenie] synonym: "inhibition of purine nucleotide biosynthetic process" NARROW [GOC:TermGenie] synonym: "inhibition of purine nucleotide formation" EXACT [GOC:TermGenie] synonym: "inhibition of purine nucleotide synthesis" EXACT [GOC:TermGenie] synonym: "negative regulation of purine nucleotide anabolism" EXACT [GOC:TermGenie] synonym: "negative regulation of purine nucleotide biosynthesis" EXACT [GOC:TermGenie] synonym: "negative regulation of purine nucleotide formation" EXACT [GOC:TermGenie] synonym: "negative regulation of purine nucleotide synthesis" EXACT [GOC:TermGenie] is_a: GO:0030809 ! negative regulation of nucleotide biosynthetic process is_a: GO:1900371 ! regulation of purine nucleotide biosynthetic process is_a: GO:1900543 ! negative regulation of purine nucleotide metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0006164 ! negatively regulates purine nucleotide biosynthetic process relationship: RO:0002212 GO:0006164 ! negatively regulates purine nucleotide biosynthetic process creation_date: 2012-04-17T12:32:27Z [Term] id: GO:1900373 name: positive regulation of purine nucleotide biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of purine nucleotide biosynthetic processes." [GOC:go_curators, GOC:TermGenie] synonym: "activation of purine nucleotide anabolism" EXACT [GOC:TermGenie] synonym: "activation of purine nucleotide biosynthesis" EXACT [GOC:TermGenie] synonym: "activation of purine nucleotide biosynthetic process" NARROW [GOC:TermGenie] synonym: "activation of purine nucleotide formation" EXACT [GOC:TermGenie] synonym: "activation of purine nucleotide synthesis" EXACT [GOC:TermGenie] synonym: "positive regulation of purine nucleotide anabolism" EXACT [GOC:TermGenie] synonym: "positive regulation of purine nucleotide biosynthesis" EXACT [GOC:TermGenie] synonym: "positive regulation of purine nucleotide formation" EXACT [GOC:TermGenie] synonym: "positive regulation of purine nucleotide synthesis" EXACT [GOC:TermGenie] synonym: "up regulation of purine nucleotide anabolism" EXACT [GOC:TermGenie] synonym: "up regulation of purine nucleotide biosynthesis" EXACT [GOC:TermGenie] synonym: "up regulation of purine nucleotide biosynthetic process" EXACT [GOC:TermGenie] synonym: "up regulation of purine nucleotide formation" EXACT [GOC:TermGenie] synonym: "up regulation of purine nucleotide synthesis" EXACT [GOC:TermGenie] synonym: "up-regulation of purine nucleotide anabolism" EXACT [GOC:TermGenie] synonym: "up-regulation of purine nucleotide biosynthesis" EXACT [GOC:TermGenie] synonym: "up-regulation of purine nucleotide biosynthetic process" EXACT [GOC:TermGenie] synonym: "up-regulation of purine nucleotide formation" EXACT [GOC:TermGenie] synonym: "up-regulation of purine nucleotide synthesis" EXACT [GOC:TermGenie] synonym: "upregulation of purine nucleotide anabolism" EXACT [GOC:TermGenie] synonym: "upregulation of purine nucleotide biosynthesis" EXACT [GOC:TermGenie] synonym: "upregulation of purine nucleotide biosynthetic process" EXACT [GOC:TermGenie] synonym: "upregulation of purine nucleotide formation" EXACT [GOC:TermGenie] synonym: "upregulation of purine nucleotide synthesis" EXACT [GOC:TermGenie] is_a: GO:0030810 ! positive regulation of nucleotide biosynthetic process is_a: GO:1900371 ! regulation of purine nucleotide biosynthetic process is_a: GO:1900544 ! positive regulation of purine nucleotide metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0006164 ! positively regulates purine nucleotide biosynthetic process relationship: RO:0002213 GO:0006164 ! positively regulates purine nucleotide biosynthetic process creation_date: 2012-04-17T12:32:37Z [Term] id: GO:1900407 name: regulation of cellular response to oxidative stress namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cellular response to oxidative stress." [GOC:mah, GOC:TermGenie] synonym: "regulation of adaptive response to oxidative stress" NARROW [GOC:TermGenie] is_a: GO:0080135 ! regulation of cellular response to stress is_a: GO:1902882 ! regulation of response to oxidative stress intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0034599 ! regulates cellular response to oxidative stress relationship: RO:0002211 GO:0034599 ! regulates cellular response to oxidative stress creation_date: 2012-04-20T03:30:52Z [Term] id: GO:1900408 name: negative regulation of cellular response to oxidative stress namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of cellular response to oxidative stress." [GOC:mah, GOC:TermGenie] synonym: "down regulation of adaptive response to oxidative stress" NARROW [GOC:TermGenie] synonym: "down regulation of cellular response to oxidative stress" EXACT [GOC:TermGenie] synonym: "down-regulation of adaptive response to oxidative stress" NARROW [GOC:TermGenie] synonym: "down-regulation of cellular response to oxidative stress" EXACT [GOC:TermGenie] synonym: "downregulation of adaptive response to oxidative stress" NARROW [GOC:TermGenie] synonym: "downregulation of cellular response to oxidative stress" EXACT [GOC:TermGenie] synonym: "inhibition of adaptive response to oxidative stress" NARROW [GOC:TermGenie] synonym: "inhibition of cellular response to oxidative stress" NARROW [GOC:TermGenie] synonym: "negative regulation of adaptive response to oxidative stress" NARROW [GOC:TermGenie] is_a: GO:0048523 ! negative regulation of cellular process is_a: GO:1900407 ! regulation of cellular response to oxidative stress is_a: GO:1902883 ! negative regulation of response to oxidative stress intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0034599 ! negatively regulates cellular response to oxidative stress relationship: RO:0002212 GO:0034599 ! negatively regulates cellular response to oxidative stress creation_date: 2012-04-20T03:31:05Z [Term] id: GO:1900409 name: positive regulation of cellular response to oxidative stress namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cellular response to oxidative stress." [GOC:mah, GOC:TermGenie] synonym: "activation of adaptive response to oxidative stress" NARROW [GOC:TermGenie] synonym: "activation of cellular response to oxidative stress" NARROW [GOC:TermGenie] synonym: "positive regulation of adaptive response to oxidative stress" NARROW [GOC:TermGenie] synonym: "up regulation of adaptive response to oxidative stress" NARROW [GOC:TermGenie] synonym: "up regulation of cellular response to oxidative stress" EXACT [GOC:TermGenie] synonym: "up-regulation of adaptive response to oxidative stress" NARROW [GOC:TermGenie] synonym: "up-regulation of cellular response to oxidative stress" EXACT [GOC:TermGenie] synonym: "upregulation of adaptive response to oxidative stress" NARROW [GOC:TermGenie] synonym: "upregulation of cellular response to oxidative stress" EXACT [GOC:TermGenie] is_a: GO:0048522 ! positive regulation of cellular process is_a: GO:1900407 ! regulation of cellular response to oxidative stress is_a: GO:1902884 ! positive regulation of response to oxidative stress intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0034599 ! positively regulates cellular response to oxidative stress relationship: RO:0002213 GO:0034599 ! positively regulates cellular response to oxidative stress creation_date: 2012-04-20T03:31:16Z [Term] id: GO:1900419 name: regulation of alcohol catabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of alcohol catabolic process within a cell." [GOC:TermGenie] is_a: GO:0009894 ! regulation of catabolic process is_a: GO:0062012 ! regulation of small molecule metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0046164 ! regulates alcohol catabolic process relationship: RO:0002211 GO:0046164 ! regulates alcohol catabolic process property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/28908" xsd:anyURI creation_date: 2012-04-20T10:21:18Z [Term] id: GO:1900420 name: negative regulation of alcohol catabolic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of alcohol catabolic process within a cell." [GOC:TermGenie] synonym: "down regulation of cellular alcohol catabolic process" EXACT [GOC:TermGenie] synonym: "down-regulation of cellular alcohol catabolic process" EXACT [GOC:TermGenie] synonym: "downregulation of cellular alcohol catabolic process" EXACT [GOC:TermGenie] synonym: "inhibition of cellular alcohol catabolic process" NARROW [GOC:TermGenie] is_a: GO:0009895 ! negative regulation of catabolic process is_a: GO:0062014 ! negative regulation of small molecule metabolic process is_a: GO:1900419 ! regulation of alcohol catabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0046164 ! negatively regulates alcohol catabolic process relationship: RO:0002212 GO:0046164 ! negatively regulates alcohol catabolic process creation_date: 2012-04-20T10:21:28Z [Term] id: GO:1900421 name: positive regulation of alcohol catabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of alcohol catabolic process within a cell." [GOC:TermGenie] synonym: "activation of cellular alcohol catabolic process" NARROW [GOC:TermGenie] synonym: "up regulation of cellular alcohol catabolic process" EXACT [GOC:TermGenie] synonym: "up-regulation of cellular alcohol catabolic process" EXACT [GOC:TermGenie] synonym: "upregulation of cellular alcohol catabolic process" EXACT [GOC:TermGenie] is_a: GO:0009896 ! positive regulation of catabolic process is_a: GO:0062013 ! positive regulation of small molecule metabolic process is_a: GO:1900419 ! regulation of alcohol catabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0046164 ! positively regulates alcohol catabolic process relationship: RO:0002213 GO:0046164 ! positively regulates alcohol catabolic process property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/28908" xsd:anyURI creation_date: 2012-04-20T10:21:46Z [Term] id: GO:1900424 name: regulation of defense response to bacterium namespace: biological_process def: "Any process that modulates the frequency, rate or extent of defense response to bacterium." [GOC:TermGenie, PMID:22346749] synonym: "regulation of antibacterial peptide activity" RELATED [GOC:TermGenie] synonym: "regulation of defence response to bacteria" EXACT [GOC:TermGenie] synonym: "regulation of defence response to bacterium" EXACT [GOC:TermGenie] synonym: "regulation of defence response to bacterium, incompatible interaction" NARROW [GOC:TermGenie] synonym: "regulation of defence response to pathogenic bacteria, incompatible interaction" NARROW [GOC:TermGenie] synonym: "regulation of defence response to pathogenic bacterium, incompatible interaction" NARROW [GOC:TermGenie] synonym: "regulation of defense response to bacteria" EXACT [GOC:TermGenie] synonym: "regulation of defense response to bacterium, incompatible interaction" NARROW [] synonym: "regulation of resistance response to pathogenic bacteria" NARROW [GOC:TermGenie] synonym: "regulation of resistance response to pathogenic bacterium" NARROW [GOC:TermGenie] is_a: GO:0002831 ! regulation of response to biotic stimulus is_a: GO:0031347 ! regulation of defense response is_a: GO:0032101 ! regulation of response to external stimulus intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0042742 ! regulates defense response to bacterium relationship: RO:0002211 GO:0042742 ! regulates defense response to bacterium property_value: RO:0002161 NCBITaxon:4895 creation_date: 2012-04-24T10:12:43Z [Term] id: GO:1900425 name: negative regulation of defense response to bacterium namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of defense response to bacterium." [GOC:TermGenie, PMID:22346749] synonym: "down regulation of antibacterial peptide activity" RELATED [GOC:TermGenie] synonym: "down regulation of defence response to bacteria" EXACT [GOC:TermGenie] synonym: "down regulation of defence response to bacterium" EXACT [GOC:TermGenie] synonym: "down regulation of defense response to bacteria" EXACT [GOC:TermGenie] synonym: "down regulation of defense response to bacterium" EXACT [GOC:TermGenie] synonym: "down-regulation of antibacterial peptide activity" RELATED [GOC:TermGenie] synonym: "down-regulation of defence response to bacteria" EXACT [GOC:TermGenie] synonym: "down-regulation of defence response to bacterium" EXACT [GOC:TermGenie] synonym: "down-regulation of defense response to bacteria" EXACT [GOC:TermGenie] synonym: "down-regulation of defense response to bacterium" EXACT [GOC:TermGenie] synonym: "downregulation of antibacterial peptide activity" RELATED [GOC:TermGenie] synonym: "downregulation of defence response to bacteria" EXACT [GOC:TermGenie] synonym: "downregulation of defence response to bacterium" EXACT [GOC:TermGenie] synonym: "downregulation of defense response to bacteria" EXACT [GOC:TermGenie] synonym: "downregulation of defense response to bacterium" EXACT [GOC:TermGenie] synonym: "inhibition of antibacterial peptide activity" RELATED [GOC:TermGenie] synonym: "inhibition of defence response to bacteria" EXACT [GOC:TermGenie] synonym: "inhibition of defence response to bacterium" EXACT [GOC:TermGenie] synonym: "inhibition of defence response to pathogenic bacteria, incompatible interaction" NARROW [GOC:TermGenie] synonym: "inhibition of defence response to pathogenic bacterium, incompatible interaction" NARROW [GOC:TermGenie] synonym: "inhibition of defense response to bacteria" EXACT [GOC:TermGenie] synonym: "inhibition of defense response to bacterium" NARROW [GOC:TermGenie] synonym: "inhibition of defense response to bacterium, incompatible interaction" NARROW [GOC:TermGenie] synonym: "inhibition of resistance response to pathogenic bacteria" NARROW [GOC:TermGenie] synonym: "inhibition of resistance response to pathogenic bacterium" NARROW [GOC:TermGenie] synonym: "inhibition of response to pathogenic bacteria (incompatible interaction)" NARROW [GOC:TermGenie] synonym: "inhibition of response to pathogenic bacterium (incompatible interaction)" NARROW [GOC:TermGenie] synonym: "negative regulation of antibacterial peptide activity" RELATED [GOC:TermGenie] synonym: "negative regulation of defence response to bacteria" EXACT [GOC:TermGenie] synonym: "negative regulation of defence response to bacterium" EXACT [GOC:TermGenie] synonym: "negative regulation of defense response to bacteria" EXACT [GOC:TermGenie] synonym: "negative regulation of defense response to bacterium, incompatible interaction" NARROW [] is_a: GO:0002832 ! negative regulation of response to biotic stimulus is_a: GO:0031348 ! negative regulation of defense response is_a: GO:0032102 ! negative regulation of response to external stimulus is_a: GO:1900424 ! regulation of defense response to bacterium intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0042742 ! negatively regulates defense response to bacterium relationship: RO:0002212 GO:0042742 ! negatively regulates defense response to bacterium property_value: RO:0002161 NCBITaxon:4895 creation_date: 2012-04-24T10:12:54Z [Term] id: GO:1900426 name: positive regulation of defense response to bacterium namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of defense response to bacterium." [GOC:TermGenie, PMID:22346749] synonym: "activation of antibacterial peptide activity" RELATED [GOC:TermGenie] synonym: "activation of defence response to bacteria" EXACT [GOC:TermGenie] synonym: "activation of defence response to bacterium" EXACT [GOC:TermGenie] synonym: "activation of defense response to bacteria" EXACT [GOC:TermGenie] synonym: "activation of defense response to bacterium" NARROW [GOC:TermGenie] synonym: "activation of resistance response to pathogenic bacteria" NARROW [GOC:TermGenie] synonym: "activation of resistance response to pathogenic bacterium" NARROW [GOC:TermGenie] synonym: "positive regulation of antibacterial peptide activity" RELATED [GOC:TermGenie] synonym: "positive regulation of defence response to bacteria" EXACT [GOC:TermGenie] synonym: "positive regulation of defence response to bacterium" EXACT [GOC:TermGenie] synonym: "positive regulation of defense response to bacteria" EXACT [GOC:TermGenie] synonym: "positive regulation of defense response to bacterium, incompatible interaction" NARROW [] synonym: "up regulation of antibacterial peptide activity" RELATED [GOC:TermGenie] synonym: "up regulation of defence response to bacteria" EXACT [GOC:TermGenie] synonym: "up regulation of defence response to bacterium" EXACT [GOC:TermGenie] synonym: "up regulation of defense response to bacteria" EXACT [GOC:TermGenie] synonym: "up regulation of defense response to bacterium" EXACT [GOC:TermGenie] synonym: "up-regulation of antibacterial peptide activity" RELATED [GOC:TermGenie] synonym: "up-regulation of defence response to bacteria" EXACT [GOC:TermGenie] synonym: "up-regulation of defence response to bacterium" EXACT [GOC:TermGenie] synonym: "up-regulation of defense response to bacteria" EXACT [GOC:TermGenie] synonym: "up-regulation of defense response to bacterium" EXACT [GOC:TermGenie] synonym: "upregulation of antibacterial peptide activity" RELATED [GOC:TermGenie] synonym: "upregulation of defence response to bacteria" EXACT [GOC:TermGenie] synonym: "upregulation of defence response to bacterium" EXACT [GOC:TermGenie] synonym: "upregulation of defense response to bacteria" EXACT [GOC:TermGenie] synonym: "upregulation of defense response to bacterium" EXACT [GOC:TermGenie] is_a: GO:0002833 ! positive regulation of response to biotic stimulus is_a: GO:0031349 ! positive regulation of defense response is_a: GO:0032103 ! positive regulation of response to external stimulus is_a: GO:1900424 ! regulation of defense response to bacterium intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0042742 ! positively regulates defense response to bacterium relationship: RO:0002213 GO:0042742 ! positively regulates defense response to bacterium property_value: RO:0002161 NCBITaxon:4895 creation_date: 2012-04-24T10:13:13Z [Term] id: GO:1900449 name: regulation of glutamate receptor signaling pathway namespace: biological_process def: "Any process that modulates the frequency, rate or extent of glutamate receptor signaling pathway." [GOC:BHF, GOC:TermGenie] synonym: "regulation of glutamate signaling pathway" EXACT [GOC:TermGenie] synonym: "regulation of glutamate signalling pathway" EXACT [GOC:TermGenie] is_a: GO:0009966 ! regulation of signal transduction intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0007215 ! regulates glutamate receptor signaling pathway relationship: RO:0002211 GO:0007215 ! regulates glutamate receptor signaling pathway creation_date: 2012-04-27T03:45:43Z [Term] id: GO:1900450 name: negative regulation of glutamate receptor signaling pathway namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of glutamate receptor signaling pathway." [GOC:BHF, GOC:TermGenie] synonym: "down regulation of glutamate receptor signaling pathway" EXACT [GOC:TermGenie] synonym: "down regulation of glutamate signaling pathway" EXACT [GOC:TermGenie] synonym: "down regulation of glutamate signalling pathway" EXACT [GOC:TermGenie] synonym: "down-regulation of glutamate receptor signaling pathway" EXACT [GOC:TermGenie] synonym: "down-regulation of glutamate signaling pathway" EXACT [GOC:TermGenie] synonym: "down-regulation of glutamate signalling pathway" EXACT [GOC:TermGenie] synonym: "downregulation of glutamate receptor signaling pathway" EXACT [GOC:TermGenie] synonym: "downregulation of glutamate signaling pathway" EXACT [GOC:TermGenie] synonym: "downregulation of glutamate signalling pathway" EXACT [GOC:TermGenie] synonym: "inhibition of glutamate receptor signaling pathway" NARROW [GOC:TermGenie] synonym: "inhibition of glutamate signaling pathway" EXACT [GOC:TermGenie] synonym: "inhibition of glutamate signalling pathway" EXACT [GOC:TermGenie] synonym: "negative regulation of glutamate signaling pathway" EXACT [GOC:TermGenie] synonym: "negative regulation of glutamate signalling pathway" EXACT [GOC:TermGenie] is_a: GO:0009968 ! negative regulation of signal transduction is_a: GO:1900449 ! regulation of glutamate receptor signaling pathway intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0007215 ! negatively regulates glutamate receptor signaling pathway relationship: RO:0002212 GO:0007215 ! negatively regulates glutamate receptor signaling pathway creation_date: 2012-04-27T03:45:53Z [Term] id: GO:1900451 name: positive regulation of glutamate receptor signaling pathway namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of glutamate receptor signaling pathway." [GOC:BHF, GOC:TermGenie] synonym: "activation of glutamate receptor signaling pathway" NARROW [GOC:TermGenie] synonym: "activation of glutamate signaling pathway" EXACT [GOC:TermGenie] synonym: "activation of glutamate signalling pathway" EXACT [GOC:TermGenie] synonym: "positive regulation of glutamate signaling pathway" EXACT [GOC:TermGenie] synonym: "positive regulation of glutamate signalling pathway" EXACT [GOC:TermGenie] synonym: "up regulation of glutamate receptor signaling pathway" EXACT [GOC:TermGenie] synonym: "up regulation of glutamate signaling pathway" EXACT [GOC:TermGenie] synonym: "up regulation of glutamate signalling pathway" EXACT [GOC:TermGenie] synonym: "up-regulation of glutamate receptor signaling pathway" EXACT [GOC:TermGenie] synonym: "up-regulation of glutamate signaling pathway" EXACT [GOC:TermGenie] synonym: "up-regulation of glutamate signalling pathway" EXACT [GOC:TermGenie] synonym: "upregulation of glutamate receptor signaling pathway" EXACT [GOC:TermGenie] synonym: "upregulation of glutamate signaling pathway" EXACT [GOC:TermGenie] synonym: "upregulation of glutamate signalling pathway" EXACT [GOC:TermGenie] is_a: GO:0009967 ! positive regulation of signal transduction is_a: GO:1900449 ! regulation of glutamate receptor signaling pathway intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0007215 ! positively regulates glutamate receptor signaling pathway relationship: RO:0002213 GO:0007215 ! positively regulates glutamate receptor signaling pathway creation_date: 2012-04-27T03:46:03Z [Term] id: GO:1900542 name: regulation of purine nucleotide metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of purine nucleotide metabolic process." [GOC:TermGenie] synonym: "regulation of purine metabolic process" NARROW [GOC:TermGenie] synonym: "regulation of purine metabolism" NARROW [GOC:TermGenie] synonym: "regulation of purine nucleotide metabolism" EXACT [GOC:TermGenie] is_a: GO:0006140 ! regulation of nucleotide metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0006163 ! regulates purine nucleotide metabolic process relationship: RO:0002211 GO:0006163 ! regulates purine nucleotide metabolic process creation_date: 2012-05-11T05:43:15Z [Term] id: GO:1900543 name: negative regulation of purine nucleotide metabolic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of purine nucleotide metabolic process." [GOC:TermGenie] synonym: "down regulation of purine metabolic process" NARROW [GOC:TermGenie] synonym: "down regulation of purine metabolism" NARROW [GOC:TermGenie] synonym: "down regulation of purine nucleotide metabolic process" EXACT [GOC:TermGenie] synonym: "down regulation of purine nucleotide metabolism" EXACT [GOC:TermGenie] synonym: "down-regulation of purine metabolic process" NARROW [GOC:TermGenie] synonym: "down-regulation of purine metabolism" NARROW [GOC:TermGenie] synonym: "down-regulation of purine nucleotide metabolic process" EXACT [GOC:TermGenie] synonym: "down-regulation of purine nucleotide metabolism" EXACT [GOC:TermGenie] synonym: "downregulation of purine metabolic process" NARROW [GOC:TermGenie] synonym: "downregulation of purine metabolism" NARROW [GOC:TermGenie] synonym: "downregulation of purine nucleotide metabolic process" EXACT [GOC:TermGenie] synonym: "downregulation of purine nucleotide metabolism" EXACT [GOC:TermGenie] synonym: "inhibition of purine metabolic process" NARROW [GOC:TermGenie] synonym: "inhibition of purine metabolism" NARROW [GOC:TermGenie] synonym: "inhibition of purine nucleotide metabolic process" NARROW [GOC:TermGenie] synonym: "inhibition of purine nucleotide metabolism" NARROW [GOC:TermGenie] synonym: "negative regulation of purine metabolic process" NARROW [GOC:TermGenie] synonym: "negative regulation of purine metabolism" NARROW [GOC:TermGenie] synonym: "negative regulation of purine nucleotide metabolism" EXACT [GOC:TermGenie] is_a: GO:0045980 ! negative regulation of nucleotide metabolic process is_a: GO:1900542 ! regulation of purine nucleotide metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0006163 ! negatively regulates purine nucleotide metabolic process relationship: RO:0002212 GO:0006163 ! negatively regulates purine nucleotide metabolic process creation_date: 2012-05-11T05:44:21Z [Term] id: GO:1900544 name: positive regulation of purine nucleotide metabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of purine nucleotide metabolic process." [GOC:TermGenie] synonym: "activation of purine metabolic process" NARROW [GOC:TermGenie] synonym: "activation of purine metabolism" NARROW [GOC:TermGenie] synonym: "activation of purine nucleotide metabolic process" NARROW [GOC:TermGenie] synonym: "activation of purine nucleotide metabolism" NARROW [GOC:TermGenie] synonym: "positive regulation of purine metabolic process" NARROW [GOC:TermGenie] synonym: "positive regulation of purine metabolism" NARROW [GOC:TermGenie] synonym: "positive regulation of purine nucleotide metabolism" EXACT [GOC:TermGenie] synonym: "up regulation of purine metabolic process" NARROW [GOC:TermGenie] synonym: "up regulation of purine metabolism" NARROW [GOC:TermGenie] synonym: "up regulation of purine nucleotide metabolic process" EXACT [GOC:TermGenie] synonym: "up regulation of purine nucleotide metabolism" EXACT [GOC:TermGenie] synonym: "up-regulation of purine metabolic process" NARROW [GOC:TermGenie] synonym: "up-regulation of purine metabolism" NARROW [GOC:TermGenie] synonym: "up-regulation of purine nucleotide metabolic process" EXACT [GOC:TermGenie] synonym: "up-regulation of purine nucleotide metabolism" EXACT [GOC:TermGenie] synonym: "upregulation of purine metabolic process" NARROW [GOC:TermGenie] synonym: "upregulation of purine metabolism" NARROW [GOC:TermGenie] synonym: "upregulation of purine nucleotide metabolic process" EXACT [GOC:TermGenie] synonym: "upregulation of purine nucleotide metabolism" EXACT [GOC:TermGenie] is_a: GO:0045981 ! positive regulation of nucleotide metabolic process is_a: GO:1900542 ! regulation of purine nucleotide metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0006163 ! positively regulates purine nucleotide metabolic process relationship: RO:0002213 GO:0006163 ! positively regulates purine nucleotide metabolic process creation_date: 2012-05-11T05:44:43Z [Term] id: GO:1900825 name: regulation of membrane depolarization during cardiac muscle cell action potential namespace: biological_process def: "Any process that modulates the frequency, rate or extent of membrane depolarization during a cardiac muscle cell action potential." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:TermGenie] is_a: GO:0098902 ! regulation of membrane depolarization during action potential intersection_of: GO:0050789 ! regulation of biological process intersection_of: RO:0002211 GO:0086012 ! regulates membrane depolarization during cardiac muscle cell action potential relationship: RO:0002211 GO:0086012 ! regulates membrane depolarization during cardiac muscle cell action potential property_value: RO:0002161 NCBITaxon:4895 creation_date: 2012-06-06T04:15:20Z [Term] id: GO:1900826 name: negative regulation of membrane depolarization during cardiac muscle cell action potential namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of membrane depolarization during a cardiac muscle cell action potential." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:TermGenie] synonym: "down regulation of membrane depolarization during cardiac muscle cell action potential" EXACT [GOC:TermGenie] synonym: "down-regulation of membrane depolarization during of cardiac muscle cell action potential" EXACT [GOC:TermGenie] synonym: "downregulation of membrane depolarization during cardiac muscle cell action potential" EXACT [GOC:TermGenie] synonym: "inhibition of membrane depolarization during cardiac muscle cell action potential" NARROW [GOC:TermGenie] is_a: GO:1900825 ! regulation of membrane depolarization during cardiac muscle cell action potential is_a: GO:1904180 ! negative regulation of membrane depolarization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0086012 ! negatively regulates membrane depolarization during cardiac muscle cell action potential relationship: RO:0002212 GO:0086012 ! negatively regulates membrane depolarization during cardiac muscle cell action potential property_value: RO:0002161 NCBITaxon:4895 creation_date: 2012-06-06T04:15:40Z [Term] id: GO:1900827 name: positive regulation of membrane depolarization during cardiac muscle cell action potential namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of membrane depolarization during a cardiac muscle cell action potential." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:TermGenie] synonym: "activation of membrane depolarization during cardiac muscle cell action potential" NARROW [GOC:TermGenie] synonym: "up regulation of membrane depolarization during cardiac muscle cell action potential" EXACT [GOC:TermGenie] synonym: "up-regulation of membrane depolarization during cardiac muscle cell action potential" EXACT [GOC:TermGenie] synonym: "upregulation of membrane depolarization during cardiac muscle cell action potential" EXACT [GOC:TermGenie] is_a: GO:1900825 ! regulation of membrane depolarization during cardiac muscle cell action potential is_a: GO:1904181 ! positive regulation of membrane depolarization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0086012 ! positively regulates membrane depolarization during cardiac muscle cell action potential relationship: RO:0002213 GO:0086012 ! positively regulates membrane depolarization during cardiac muscle cell action potential property_value: RO:0002161 NCBITaxon:4895 creation_date: 2012-06-06T04:15:48Z [Term] id: GO:1900923 name: regulation of glycine import across plasma membrane namespace: biological_process def: "Any process that modulates the frequency, rate or extent of glycine import into a cell." [GOC:TermGenie] synonym: "regulation of glycine import" BROAD [] is_a: GO:0010958 ! regulation of amino acid import across plasma membrane is_a: GO:0032890 ! regulation of organic acid transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:1903804 ! regulates glycine import across plasma membrane relationship: RO:0002211 GO:1903804 ! regulates glycine import across plasma membrane creation_date: 2012-06-13T07:40:11Z [Term] id: GO:1900924 name: negative regulation of glycine import across plasma membrane namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of glycine import into a cell." [GOC:TermGenie] synonym: "down regulation of glycine import" EXACT [GOC:TermGenie] synonym: "down-regulation of glycine import" EXACT [GOC:TermGenie] synonym: "downregulation of glycine import" EXACT [GOC:TermGenie] synonym: "inhibition of glycine import" NARROW [GOC:TermGenie] synonym: "negative regulation of glycine import" BROAD [] is_a: GO:0032891 ! negative regulation of organic acid transport is_a: GO:0034763 ! negative regulation of transmembrane transport is_a: GO:0051956 ! negative regulation of amino acid transport is_a: GO:1900923 ! regulation of glycine import across plasma membrane intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:1903804 ! negatively regulates glycine import across plasma membrane relationship: RO:0002212 GO:1903804 ! negatively regulates glycine import across plasma membrane creation_date: 2012-06-13T07:40:32Z [Term] id: GO:1900925 name: positive regulation of glycine import across plasma membrane namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of glycine import." [GOC:TermGenie] synonym: "activation of glycine import" NARROW [GOC:TermGenie] synonym: "positive regulation of glycine import" BROAD [] synonym: "up regulation of glycine import" EXACT [GOC:TermGenie] synonym: "up-regulation of glycine import" EXACT [GOC:TermGenie] synonym: "upregulation of glycine import" EXACT [GOC:TermGenie] is_a: GO:0032892 ! positive regulation of organic acid transport is_a: GO:0034764 ! positive regulation of transmembrane transport is_a: GO:0051957 ! positive regulation of amino acid transport is_a: GO:1900923 ! regulation of glycine import across plasma membrane intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:1903804 ! positively regulates glycine import across plasma membrane relationship: RO:0002213 GO:1903804 ! positively regulates glycine import across plasma membrane creation_date: 2012-06-13T07:40:40Z [Term] id: GO:1901017 name: negative regulation of potassium ion transmembrane transporter activity namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of potassium ion transmembrane transporter activity." [GOC:BHF, GOC:TermGenie] subset: gocheck_obsoletion_candidate synonym: "down regulation of potassium ion transmembrane transporter activity" EXACT [GOC:TermGenie] synonym: "down regulation of potassium transporter activity" EXACT [GOC:TermGenie] synonym: "down-regulation of potassium ion transmembrane transporter activity" EXACT [GOC:TermGenie] synonym: "down-regulation of potassium transporter activity" EXACT [GOC:TermGenie] synonym: "downregulation of potassium ion transmembrane transporter activity" EXACT [GOC:TermGenie] synonym: "downregulation of potassium transporter activity" EXACT [GOC:TermGenie] synonym: "inhibition of potassium ion transmembrane transporter activity" NARROW [GOC:TermGenie] synonym: "inhibition of potassium transporter activity" EXACT [GOC:TermGenie] synonym: "negative regulation of potassium transporter activity" EXACT [GOC:TermGenie] is_a: GO:0032413 ! negative regulation of ion transmembrane transporter activity is_a: GO:1901380 ! negative regulation of potassium ion transmembrane transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0015079 ! negatively regulates potassium ion transmembrane transporter activity relationship: RO:0002212 GO:0015079 ! negatively regulates potassium ion transmembrane transporter activity creation_date: 2012-06-15T01:14:10Z [Term] id: GO:1901020 name: negative regulation of calcium ion transmembrane transporter activity namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of calcium ion transmembrane transporter activity." [GOC:BHF, GOC:TermGenie] subset: gocheck_obsoletion_candidate synonym: "down regulation of calcium ion transmembrane transporter activity" EXACT [GOC:TermGenie] synonym: "down-regulation of calcium ion transmembrane transporter activity" EXACT [GOC:TermGenie] synonym: "downregulation of calcium ion transmembrane transporter activity" EXACT [GOC:TermGenie] synonym: "inhibition of calcium ion transmembrane transporter activity" NARROW [GOC:TermGenie] is_a: GO:0032413 ! negative regulation of ion transmembrane transporter activity is_a: GO:1903170 ! negative regulation of calcium ion transmembrane transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0015085 ! negatively regulates calcium ion transmembrane transporter activity relationship: RO:0002212 GO:0015085 ! negatively regulates calcium ion transmembrane transporter activity creation_date: 2012-06-15T07:54:32Z [Term] id: GO:1901031 name: regulation of response to reactive oxygen species namespace: biological_process def: "Any process that modulates the frequency, rate or extent of response to reactive oxygen species." [GOC:kmv, GOC:TermGenie] synonym: "regulation of response to active oxygen species" EXACT [GOC:TermGenie] synonym: "regulation of response to AOS" EXACT [GOC:TermGenie] synonym: "regulation of response to reactive oxidative species" EXACT [GOC:TermGenie] synonym: "regulation of response to reactive oxygen intermediate" EXACT [GOC:TermGenie] synonym: "regulation of response to ROI" EXACT [GOC:TermGenie] synonym: "regulation of response to ROS" EXACT [GOC:TermGenie] is_a: GO:1902882 ! regulation of response to oxidative stress intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0000302 ! regulates response to reactive oxygen species relationship: RO:0002211 GO:0000302 ! regulates response to reactive oxygen species creation_date: 2012-06-20T07:47:06Z [Term] id: GO:1901032 name: negative regulation of response to reactive oxygen species namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of response to reactive oxygen species." [GOC:kmv, GOC:TermGenie] synonym: "down regulation of response to active oxygen species" EXACT [GOC:TermGenie] synonym: "down regulation of response to AOS" EXACT [GOC:TermGenie] synonym: "down regulation of response to reactive oxidative species" EXACT [GOC:TermGenie] synonym: "down regulation of response to reactive oxygen intermediate" EXACT [GOC:TermGenie] synonym: "down regulation of response to reactive oxygen species" EXACT [GOC:TermGenie] synonym: "down regulation of response to ROI" EXACT [GOC:TermGenie] synonym: "down regulation of response to ROS" EXACT [GOC:TermGenie] synonym: "down-regulation of response to active oxygen species" EXACT [GOC:TermGenie] synonym: "down-regulation of response to AOS" EXACT [GOC:TermGenie] synonym: "down-regulation of response to reactive oxidative species" EXACT [GOC:TermGenie] synonym: "down-regulation of response to reactive oxygen intermediate" EXACT [GOC:TermGenie] synonym: "down-regulation of response to reactive oxygen species" EXACT [GOC:TermGenie] synonym: "down-regulation of response to ROI" EXACT [GOC:TermGenie] synonym: "down-regulation of response to ROS" EXACT [GOC:TermGenie] synonym: "downregulation of response to active oxygen species" EXACT [GOC:TermGenie] synonym: "downregulation of response to AOS" EXACT [GOC:TermGenie] synonym: "downregulation of response to reactive oxidative species" EXACT [GOC:TermGenie] synonym: "downregulation of response to reactive oxygen intermediate" EXACT [GOC:TermGenie] synonym: "downregulation of response to reactive oxygen species" EXACT [GOC:TermGenie] synonym: "downregulation of response to ROI" EXACT [GOC:TermGenie] synonym: "downregulation of response to ROS" EXACT [GOC:TermGenie] synonym: "inhibition of response to active oxygen species" EXACT [GOC:TermGenie] synonym: "inhibition of response to AOS" EXACT [GOC:TermGenie] synonym: "inhibition of response to reactive oxidative species" EXACT [GOC:TermGenie] synonym: "inhibition of response to reactive oxygen intermediate" EXACT [GOC:TermGenie] synonym: "inhibition of response to reactive oxygen species" NARROW [GOC:TermGenie] synonym: "inhibition of response to ROI" EXACT [GOC:TermGenie] synonym: "inhibition of response to ROS" EXACT [GOC:TermGenie] synonym: "negative regulation of response to active oxygen species" EXACT [GOC:TermGenie] synonym: "negative regulation of response to AOS" EXACT [GOC:TermGenie] synonym: "negative regulation of response to reactive oxidative species" EXACT [GOC:TermGenie] synonym: "negative regulation of response to reactive oxygen intermediate" EXACT [GOC:TermGenie] synonym: "negative regulation of response to ROI" EXACT [GOC:TermGenie] synonym: "negative regulation of response to ROS" EXACT [GOC:TermGenie] is_a: GO:1901031 ! regulation of response to reactive oxygen species is_a: GO:1902883 ! negative regulation of response to oxidative stress intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0000302 ! negatively regulates response to reactive oxygen species relationship: RO:0002212 GO:0000302 ! negatively regulates response to reactive oxygen species creation_date: 2012-06-20T07:47:28Z [Term] id: GO:1901033 name: positive regulation of response to reactive oxygen species namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of response to reactive oxygen species." [GOC:kmv, GOC:TermGenie] synonym: "activation of response to active oxygen species" EXACT [GOC:TermGenie] synonym: "activation of response to AOS" EXACT [GOC:TermGenie] synonym: "activation of response to reactive oxidative species" EXACT [GOC:TermGenie] synonym: "activation of response to reactive oxygen intermediate" EXACT [GOC:TermGenie] synonym: "activation of response to reactive oxygen species" NARROW [GOC:TermGenie] synonym: "activation of response to ROI" EXACT [GOC:TermGenie] synonym: "activation of response to ROS" EXACT [GOC:TermGenie] synonym: "positive regulation of response to active oxygen species" EXACT [GOC:TermGenie] synonym: "positive regulation of response to AOS" EXACT [GOC:TermGenie] synonym: "positive regulation of response to reactive oxidative species" EXACT [GOC:TermGenie] synonym: "positive regulation of response to reactive oxygen intermediate" EXACT [GOC:TermGenie] synonym: "positive regulation of response to ROI" EXACT [GOC:TermGenie] synonym: "positive regulation of response to ROS" EXACT [GOC:TermGenie] synonym: "up regulation of response to active oxygen species" EXACT [GOC:TermGenie] synonym: "up regulation of response to AOS" EXACT [GOC:TermGenie] synonym: "up regulation of response to reactive oxidative species" EXACT [GOC:TermGenie] synonym: "up regulation of response to reactive oxygen intermediate" EXACT [GOC:TermGenie] synonym: "up regulation of response to reactive oxygen species" EXACT [GOC:TermGenie] synonym: "up regulation of response to ROI" EXACT [GOC:TermGenie] synonym: "up regulation of response to ROS" EXACT [GOC:TermGenie] synonym: "up-regulation of response to active oxygen species" EXACT [GOC:TermGenie] synonym: "up-regulation of response to AOS" EXACT [GOC:TermGenie] synonym: "up-regulation of response to reactive oxidative species" EXACT [GOC:TermGenie] synonym: "up-regulation of response to reactive oxygen intermediate" EXACT [GOC:TermGenie] synonym: "up-regulation of response to reactive oxygen species" EXACT [GOC:TermGenie] synonym: "up-regulation of response to ROI" EXACT [GOC:TermGenie] synonym: "up-regulation of response to ROS" EXACT [GOC:TermGenie] synonym: "upregulation of response to active oxygen species" EXACT [GOC:TermGenie] synonym: "upregulation of response to AOS" EXACT [GOC:TermGenie] synonym: "upregulation of response to reactive oxidative species" EXACT [GOC:TermGenie] synonym: "upregulation of response to reactive oxygen intermediate" EXACT [GOC:TermGenie] synonym: "upregulation of response to reactive oxygen species" EXACT [GOC:TermGenie] synonym: "upregulation of response to ROI" EXACT [GOC:TermGenie] synonym: "upregulation of response to ROS" EXACT [GOC:TermGenie] is_a: GO:1901031 ! regulation of response to reactive oxygen species is_a: GO:1902884 ! positive regulation of response to oxidative stress intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0000302 ! positively regulates response to reactive oxygen species relationship: RO:0002213 GO:0000302 ! positively regulates response to reactive oxygen species creation_date: 2012-06-20T07:47:35Z [Term] id: GO:1901135 name: carbohydrate derivative metabolic process namespace: biological_process def: "The chemical reactions and pathways involving carbohydrate derivative." [GOC:TermGenie] subset: goslim_agr subset: goslim_generic subset: goslim_mouse subset: goslim_prokaryote synonym: "carbohydrate derivative metabolism" EXACT [GOC:TermGenie] is_a: BFO:0000003 is_a: GO:0008152 ! metabolic process intersection_of: GO:0008152 ! metabolic process intersection_of: RO:0004007 CHEBI:63299 ! has primary input or output relationship: RO:0004007 CHEBI:63299 ! has primary input or output creation_date: 2012-07-12T04:05:09Z [Term] id: GO:1901136 name: carbohydrate derivative catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of carbohydrate derivative." [GOC:TermGenie] synonym: "carbohydrate derivative breakdown" EXACT [GOC:TermGenie] synonym: "carbohydrate derivative catabolism" EXACT [GOC:TermGenie] synonym: "carbohydrate derivative degradation" EXACT [GOC:TermGenie] is_a: GO:0009056 ! catabolic process is_a: GO:1901135 ! carbohydrate derivative metabolic process intersection_of: GO:0009056 ! catabolic process intersection_of: RO:0004009 CHEBI:63299 ! has primary input relationship: RO:0004009 CHEBI:63299 ! has primary input creation_date: 2012-07-12T04:05:31Z [Term] id: GO:1901137 name: carbohydrate derivative biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of carbohydrate derivative." [GOC:TermGenie] synonym: "carbohydrate derivative anabolism" EXACT [GOC:TermGenie] synonym: "carbohydrate derivative biosynthesis" EXACT [GOC:TermGenie] synonym: "carbohydrate derivative formation" EXACT [GOC:TermGenie] synonym: "carbohydrate derivative synthesis" EXACT [GOC:TermGenie] is_a: GO:0009058 ! biosynthetic process is_a: GO:1901135 ! carbohydrate derivative metabolic process intersection_of: GO:0009058 ! biosynthetic process intersection_of: RO:0004008 CHEBI:63299 ! has primary output relationship: RO:0004008 CHEBI:63299 ! has primary output creation_date: 2012-07-12T04:05:39Z [Term] id: GO:1901142 name: insulin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving insulin." [GOC:TermGenie] synonym: "insulin metabolism" EXACT [GOC:TermGenie] is_a: GO:0019538 ! protein metabolic process intersection_of: GO:0008152 ! metabolic process intersection_of: RO:0004007 PR:000009054 ! has primary input or output preproinsulin relationship: RO:0004007 PR:000009054 ! has primary input or output preproinsulin property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:33090 property_value: RO:0002161 NCBITaxon:4751 creation_date: 2012-07-13T12:32:40Z [Term] id: GO:1901143 name: insulin catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of insulin." [GOC:TermGenie] synonym: "insulin breakdown" EXACT [GOC:TermGenie] synonym: "insulin catabolism" EXACT [GOC:TermGenie] synonym: "insulin degradation" EXACT [GOC:TermGenie] is_a: GO:0030163 ! protein catabolic process is_a: GO:1901142 ! insulin metabolic process intersection_of: GO:0009056 ! catabolic process intersection_of: RO:0004009 PR:000009054 ! has primary input preproinsulin relationship: RO:0004009 PR:000009054 ! has primary input preproinsulin property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:33090 property_value: RO:0002161 NCBITaxon:4751 creation_date: 2012-07-13T12:33:03Z [Term] id: GO:1901145 name: mesenchymal cell apoptotic process involved in nephron morphogenesis namespace: biological_process def: "Any mesenchymal cell apoptotic process that is involved in nephron morphogenesis." [GOC:mtg_apoptosis, GOC:TermGenie] is_a: GO:0060561 ! apoptotic process involved in morphogenesis is_a: GO:0097152 ! mesenchymal cell apoptotic process intersection_of: GO:0097152 ! mesenchymal cell apoptotic process intersection_of: BFO:0000050 GO:0072028 ! part of nephron morphogenesis relationship: BFO:0000050 GO:0072028 ! part of nephron morphogenesis creation_date: 2012-07-13T01:43:51Z [Term] id: GO:1901146 name: mesenchymal cell apoptotic process involved in mesonephric nephron morphogenesis namespace: biological_process def: "Any mesenchymal cell apoptotic process that is involved in mesonephric nephron morphogenesis." [GOC:mtg_apoptosis, GOC:TermGenie] is_a: GO:1901145 ! mesenchymal cell apoptotic process involved in nephron morphogenesis intersection_of: GO:0097152 ! mesenchymal cell apoptotic process intersection_of: BFO:0000050 GO:0061228 ! part of mesonephric nephron morphogenesis relationship: BFO:0000050 GO:0061228 ! part of mesonephric nephron morphogenesis creation_date: 2012-07-13T02:40:43Z [Term] id: GO:1901147 name: mesenchymal cell apoptotic process involved in metanephric nephron morphogenesis namespace: biological_process def: "Any mesenchymal cell apoptotic process that is involved in metanephric nephron morphogenesis." [GOC:mtg_apoptosis, GOC:TermGenie] is_a: GO:1900200 ! mesenchymal cell apoptotic process involved in metanephros development is_a: GO:1901145 ! mesenchymal cell apoptotic process involved in nephron morphogenesis intersection_of: GO:0097152 ! mesenchymal cell apoptotic process intersection_of: BFO:0000050 GO:0072273 ! part of metanephric nephron morphogenesis relationship: BFO:0000050 GO:0072273 ! part of metanephric nephron morphogenesis creation_date: 2012-07-13T02:41:12Z [Term] id: GO:1901148 name: gene expression involved in extracellular matrix organization namespace: biological_process def: "Any gene expression that is involved in extracellular matrix organization. Gene expression includes both transcription to produce an RNA transcript, and the translation of that mRNA into protein. Protein maturation is included in gene expression when required to form an active form of a product from an inactive precursor form." [GOC:pg, GOC:TermGenie, PMID:18668558] synonym: "expression of extracellular matrix proteins" EXACT [GOC:bf] synonym: "extracellular matrix protein production" RELATED [GOC:pg] is_a: GO:0010467 ! gene expression intersection_of: GO:0010467 ! gene expression intersection_of: BFO:0000050 GO:0030198 ! part of extracellular matrix organization relationship: BFO:0000050 GO:0030198 ! part of extracellular matrix organization creation_date: 2012-07-16T03:29:30Z [Term] id: GO:1901161 name: primary amino compound catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of primary amino compound." [GOC:TermGenie] synonym: "primary amino compound breakdown" EXACT [GOC:TermGenie] synonym: "primary amino compound catabolism" EXACT [GOC:TermGenie] synonym: "primary amino compound degradation" EXACT [GOC:TermGenie] is_a: BFO:0000003 is_a: GO:0009056 ! catabolic process intersection_of: GO:0009056 ! catabolic process intersection_of: RO:0004009 CHEBI:50994 ! has primary input relationship: RO:0004009 CHEBI:50994 ! has primary input creation_date: 2012-07-18T04:45:06Z [Term] id: GO:1901162 name: primary amino compound biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of primary amino compound." [GOC:TermGenie] synonym: "primary amino compound anabolism" EXACT [GOC:TermGenie] synonym: "primary amino compound biosynthesis" EXACT [GOC:TermGenie] synonym: "primary amino compound formation" EXACT [GOC:TermGenie] synonym: "primary amino compound synthesis" EXACT [GOC:TermGenie] is_a: BFO:0000003 is_a: GO:0009058 ! biosynthetic process intersection_of: GO:0009058 ! biosynthetic process intersection_of: RO:0004008 CHEBI:50994 ! has primary output relationship: RO:0004008 CHEBI:50994 ! has primary output creation_date: 2012-07-18T04:45:14Z [Term] id: GO:1901163 name: regulation of trophoblast cell migration namespace: biological_process def: "Any process that modulates the frequency, rate or extent of trophoblast cell migration." [GOC:BHF, GOC:TermGenie] is_a: GO:0030334 ! regulation of cell migration intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0061450 ! regulates trophoblast cell migration relationship: RO:0002211 GO:0061450 ! regulates trophoblast cell migration creation_date: 2012-07-19T07:53:06Z [Term] id: GO:1901164 name: negative regulation of trophoblast cell migration namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of trophoblast cell migration." [GOC:BHF, GOC:TermGenie] synonym: "down regulation of trophoblast cell migration" EXACT [GOC:TermGenie] synonym: "down-regulation of trophoblast cell migration" EXACT [GOC:TermGenie] synonym: "downregulation of trophoblast cell migration" EXACT [GOC:TermGenie] synonym: "inhibition of trophoblast cell migration" NARROW [GOC:TermGenie] is_a: GO:0030336 ! negative regulation of cell migration is_a: GO:0051241 ! negative regulation of multicellular organismal process is_a: GO:1901163 ! regulation of trophoblast cell migration is_a: GO:2000242 ! negative regulation of reproductive process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0061450 ! negatively regulates trophoblast cell migration relationship: RO:0002212 GO:0061450 ! negatively regulates trophoblast cell migration creation_date: 2012-07-19T07:53:28Z [Term] id: GO:1901165 name: positive regulation of trophoblast cell migration namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of trophoblast cell migration." [GOC:BHF, GOC:TermGenie] synonym: "activation of trophoblast cell migration" NARROW [GOC:TermGenie] synonym: "up regulation of trophoblast cell migration" EXACT [GOC:TermGenie] synonym: "up-regulation of trophoblast cell migration" EXACT [GOC:TermGenie] synonym: "upregulation of trophoblast cell migration" EXACT [GOC:TermGenie] is_a: GO:0030335 ! positive regulation of cell migration is_a: GO:0051094 ! positive regulation of developmental process is_a: GO:0051240 ! positive regulation of multicellular organismal process is_a: GO:1901163 ! regulation of trophoblast cell migration is_a: GO:2000243 ! positive regulation of reproductive process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0061450 ! positively regulates trophoblast cell migration relationship: RO:0002213 GO:0061450 ! positively regulates trophoblast cell migration creation_date: 2012-07-19T07:53:35Z [Term] id: GO:1901166 name: neural crest cell migration involved in autonomic nervous system development namespace: biological_process def: "Any neural crest cell migration that is involved in autonomic nervous system development." [GOC:BHF, GOC:TermGenie] is_a: GO:0001755 ! neural crest cell migration intersection_of: GO:0001755 ! neural crest cell migration intersection_of: BFO:0000050 GO:0048483 ! part of autonomic nervous system development relationship: BFO:0000050 GO:0048483 ! part of autonomic nervous system development creation_date: 2012-07-19T08:39:56Z [Term] id: GO:1901190 name: regulation of formation of translation initiation ternary complex namespace: biological_process def: "Any process that modulates the frequency, rate or extent of formation of translation initiation ternary complex." [GOC:TermGenie] synonym: "regulation of translation initiation ternary complex assembly" EXACT [GOC:TermGenie] is_a: GO:0043254 ! regulation of protein-containing complex assembly intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0001677 ! regulates formation of translation initiation ternary complex relationship: RO:0002211 GO:0001677 ! regulates formation of translation initiation ternary complex creation_date: 2012-07-25T02:26:58Z [Term] id: GO:1901191 name: negative regulation of formation of translation initiation ternary complex namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of formation of translation initiation ternary complex." [GOC:TermGenie] synonym: "down regulation of formation of translation initiation ternary complex" EXACT [GOC:TermGenie] synonym: "down regulation of translation initiation ternary complex assembly" EXACT [GOC:TermGenie] synonym: "down-regulation of formation of translation initiation ternary complex" EXACT [GOC:TermGenie] synonym: "down-regulation of translation initiation ternary complex assembly" EXACT [GOC:TermGenie] synonym: "downregulation of formation of translation initiation ternary complex" EXACT [GOC:TermGenie] synonym: "downregulation of translation initiation ternary complex assembly" EXACT [GOC:TermGenie] synonym: "inhibition of formation of translation initiation ternary complex" NARROW [GOC:TermGenie] synonym: "inhibition of translation initiation ternary complex assembly" EXACT [GOC:TermGenie] synonym: "negative regulation of translation initiation ternary complex assembly" EXACT [GOC:TermGenie] is_a: GO:0031333 ! negative regulation of protein-containing complex assembly is_a: GO:0045947 ! negative regulation of translational initiation is_a: GO:1901190 ! regulation of formation of translation initiation ternary complex intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0001677 ! negatively regulates formation of translation initiation ternary complex relationship: RO:0002212 GO:0001677 ! negatively regulates formation of translation initiation ternary complex creation_date: 2012-07-25T02:27:21Z [Term] id: GO:1901192 name: positive regulation of formation of translation initiation ternary complex namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of formation of translation initiation ternary complex." [GOC:TermGenie] synonym: "activation of formation of translation initiation ternary complex" NARROW [GOC:TermGenie] synonym: "activation of translation initiation ternary complex assembly" EXACT [GOC:TermGenie] synonym: "positive regulation of translation initiation ternary complex assembly" EXACT [GOC:TermGenie] synonym: "up regulation of formation of translation initiation ternary complex" EXACT [GOC:TermGenie] synonym: "up regulation of translation initiation ternary complex assembly" EXACT [GOC:TermGenie] synonym: "up-regulation of formation of translation initiation ternary complex" EXACT [GOC:TermGenie] synonym: "up-regulation of translation initiation ternary complex assembly" EXACT [GOC:TermGenie] synonym: "upregulation of formation of translation initiation ternary complex" EXACT [GOC:TermGenie] synonym: "upregulation of translation initiation ternary complex assembly" EXACT [GOC:TermGenie] is_a: GO:0031334 ! positive regulation of protein-containing complex assembly is_a: GO:1901190 ! regulation of formation of translation initiation ternary complex intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0001677 ! positively regulates formation of translation initiation ternary complex relationship: RO:0002213 GO:0001677 ! positively regulates formation of translation initiation ternary complex creation_date: 2012-07-25T02:27:29Z [Term] id: GO:1901197 name: positive regulation of calcium-mediated signaling involved in cellular response to calcium ion namespace: biological_process def: "Any positive regulation of calcium-mediated signaling that is involved in cellular response to calcium ion." [GOC:TermGenie] synonym: "activation of calcium-mediated signaling involved in cellular response to Ca2+ ion" NARROW [GOC:TermGenie] synonym: "activation of calcium-mediated signaling involved in cellular response to calcium ion" NARROW [GOC:TermGenie] synonym: "positive regulation of calcium-mediated signaling involved in cellular response to Ca2+ ion" EXACT [GOC:TermGenie] synonym: "positive regulation of calcium-mediated signalling involved in cellular response to Ca2+ ion" EXACT [GOC:TermGenie] synonym: "positive regulation of calcium-mediated signalling involved in cellular response to calcium ion" EXACT [GOC:TermGenie] synonym: "stimulation of calcium-mediated signaling involved in cellular response to Ca2+ ion" NARROW [GOC:TermGenie] synonym: "stimulation of calcium-mediated signaling involved in cellular response to calcium ion" NARROW [GOC:TermGenie] synonym: "up regulation of calcium-mediated signaling involved in cellular response to Ca2+ ion" EXACT [GOC:TermGenie] synonym: "up regulation of calcium-mediated signaling involved in cellular response to calcium ion" EXACT [GOC:TermGenie] synonym: "up-regulation of calcium-mediated signaling involved in cellular response to Ca2+ ion" EXACT [GOC:TermGenie] synonym: "up-regulation of calcium-mediated signaling involved in response to calcium ion" EXACT [GOC:TermGenie] synonym: "upregulation of calcium-mediated signaling involved in cellular response to Ca2+ ion" EXACT [GOC:TermGenie] synonym: "upregulation of calcium-mediated signaling involved in cellular response to calcium ion" EXACT [GOC:TermGenie] is_a: GO:0050850 ! positive regulation of calcium-mediated signaling intersection_of: GO:0050850 ! positive regulation of calcium-mediated signaling intersection_of: BFO:0000050 GO:0071277 ! part of cellular response to calcium ion relationship: BFO:0000050 GO:0071277 ! part of cellular response to calcium ion creation_date: 2012-07-27T10:57:56Z [Term] id: GO:1901201 name: regulation of extracellular matrix assembly namespace: biological_process def: "Any process that modulates the frequency, rate or extent of extracellular matrix assembly." [GOC:BHF, GOC:TermGenie] is_a: GO:0044087 ! regulation of cellular component biogenesis is_a: GO:1903053 ! regulation of extracellular matrix organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0085029 ! regulates extracellular matrix assembly relationship: RO:0002211 GO:0085029 ! regulates extracellular matrix assembly creation_date: 2012-07-27T04:04:00Z [Term] id: GO:1901202 name: negative regulation of extracellular matrix assembly namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of extracellular matrix assembly." [GOC:BHF, GOC:TermGenie] synonym: "down regulation of extracellular matrix assembly" EXACT [GOC:TermGenie] synonym: "down-regulation of extracellular matrix assembly" EXACT [GOC:TermGenie] synonym: "downregulation of extracellular matrix assembly" EXACT [GOC:TermGenie] synonym: "inhibition of extracellular matrix assembly" NARROW [GOC:TermGenie] is_a: GO:1901201 ! regulation of extracellular matrix assembly is_a: GO:1903054 ! negative regulation of extracellular matrix organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0085029 ! negatively regulates extracellular matrix assembly relationship: RO:0002212 GO:0085029 ! negatively regulates extracellular matrix assembly creation_date: 2012-07-27T04:04:24Z [Term] id: GO:1901203 name: positive regulation of extracellular matrix assembly namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of extracellular matrix assembly." [GOC:BHF, GOC:TermGenie] synonym: "activation of extracellular matrix assembly" NARROW [GOC:TermGenie] synonym: "up regulation of extracellular matrix assembly" EXACT [GOC:TermGenie] synonym: "up-regulation of extracellular matrix assembly" EXACT [GOC:TermGenie] synonym: "upregulation of extracellular matrix assembly" EXACT [GOC:TermGenie] is_a: GO:0044089 ! positive regulation of cellular component biogenesis is_a: GO:1901201 ! regulation of extracellular matrix assembly is_a: GO:1903055 ! positive regulation of extracellular matrix organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0085029 ! positively regulates extracellular matrix assembly relationship: RO:0002213 GO:0085029 ! positively regulates extracellular matrix assembly creation_date: 2012-07-27T04:04:32Z [Term] id: GO:1901210 name: regulation of cardiac chamber formation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cardiac chamber formation." [GOC:BHF, GOC:TermGenie] synonym: "regulation of heart chamber formation" EXACT [GOC:TermGenie] is_a: GO:0050793 ! regulation of developmental process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0003207 ! regulates cardiac chamber formation relationship: RO:0002211 GO:0003207 ! regulates cardiac chamber formation creation_date: 2012-07-31T07:18:35Z [Term] id: GO:1901211 name: negative regulation of cardiac chamber formation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of cardiac chamber formation." [GOC:BHF, GOC:TermGenie] synonym: "down regulation of cardiac chamber formation" EXACT [GOC:TermGenie] synonym: "down regulation of heart chamber formation" EXACT [GOC:TermGenie] synonym: "down-regulation of cardiac chamber formation" EXACT [GOC:TermGenie] synonym: "down-regulation of heart chamber formation" EXACT [GOC:TermGenie] synonym: "downregulation of cardiac chamber formation" EXACT [GOC:TermGenie] synonym: "downregulation of heart chamber formation" EXACT [GOC:TermGenie] synonym: "inhibition of cardiac chamber formation" NARROW [GOC:TermGenie] synonym: "inhibition of heart chamber formation" EXACT [GOC:TermGenie] synonym: "negative regulation of heart chamber formation" EXACT [GOC:TermGenie] is_a: GO:0051093 ! negative regulation of developmental process is_a: GO:1901210 ! regulation of cardiac chamber formation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0003207 ! negatively regulates cardiac chamber formation relationship: RO:0002212 GO:0003207 ! negatively regulates cardiac chamber formation creation_date: 2012-07-31T07:18:57Z [Term] id: GO:1901212 name: positive regulation of cardiac chamber formation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cardiac chamber formation." [GOC:BHF, GOC:TermGenie] synonym: "activation of cardiac chamber formation" NARROW [GOC:TermGenie] synonym: "activation of heart chamber formation" EXACT [GOC:TermGenie] synonym: "positive regulation of heart chamber formation" EXACT [GOC:TermGenie] synonym: "up regulation of cardiac chamber formation" EXACT [GOC:TermGenie] synonym: "up regulation of heart chamber formation" EXACT [GOC:TermGenie] synonym: "up-regulation of cardiac chamber formation" EXACT [GOC:TermGenie] synonym: "up-regulation of heart chamber formation" EXACT [GOC:TermGenie] synonym: "upregulation of cardiac chamber formation" EXACT [GOC:TermGenie] synonym: "upregulation of heart chamber formation" EXACT [GOC:TermGenie] is_a: GO:1901210 ! regulation of cardiac chamber formation is_a: GO:1901221 ! positive regulation of cardiac chamber morphogenesis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0003207 ! positively regulates cardiac chamber formation relationship: RO:0002213 GO:0003207 ! positively regulates cardiac chamber formation creation_date: 2012-07-31T07:19:05Z [Term] id: GO:1901219 name: regulation of cardiac chamber morphogenesis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cardiac chamber morphogenesis." [GOC:BHF, GOC:TermGenie] synonym: "regulation of heart chamber morphogenesis" EXACT [GOC:TermGenie] is_a: GO:2000826 ! regulation of heart morphogenesis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0003206 ! regulates cardiac chamber morphogenesis relationship: RO:0002211 GO:0003206 ! regulates cardiac chamber morphogenesis creation_date: 2012-08-06T17:59:11Z [Term] id: GO:1901220 name: negative regulation of cardiac chamber morphogenesis namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of cardiac chamber morphogenesis." [GOC:BHF, GOC:TermGenie] synonym: "down regulation of cardiac chamber morphogenesis" EXACT [GOC:TermGenie] synonym: "down regulation of heart chamber morphogenesis" EXACT [GOC:TermGenie] synonym: "down-regulation of cardiac chamber morphogenesis" EXACT [GOC:TermGenie] synonym: "down-regulation of heart chamber morphogenesis" EXACT [GOC:TermGenie] synonym: "downregulation of cardiac chamber morphogenesis" EXACT [GOC:TermGenie] synonym: "downregulation of heart chamber morphogenesis" EXACT [GOC:TermGenie] synonym: "inhibition of cardiac chamber morphogenesis" NARROW [GOC:TermGenie] synonym: "inhibition of heart chamber morphogenesis" NARROW [GOC:TermGenie] synonym: "negative regulation of heart chamber morphogenesis" EXACT [GOC:TermGenie] is_a: GO:0051093 ! negative regulation of developmental process is_a: GO:1901219 ! regulation of cardiac chamber morphogenesis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0003206 ! negatively regulates cardiac chamber morphogenesis relationship: RO:0002212 GO:0003206 ! negatively regulates cardiac chamber morphogenesis creation_date: 2012-08-06T17:59:34Z [Term] id: GO:1901221 name: positive regulation of cardiac chamber morphogenesis namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cardiac chamber morphogenesis." [GOC:BHF, GOC:TermGenie] synonym: "activation of cardiac chamber morphogenesis" NARROW [GOC:TermGenie] synonym: "activation of heart chamber morphogenesis" NARROW [GOC:TermGenie] synonym: "positive regulation of heart chamber morphogenesis" EXACT [GOC:TermGenie] synonym: "up regulation of cardiac chamber morphogenesis" EXACT [GOC:TermGenie] synonym: "up regulation of heart chamber morphogenesis" EXACT [GOC:TermGenie] synonym: "up-regulation of cardiac chamber morphogenesis" EXACT [GOC:TermGenie] synonym: "up-regulation of heart chamber morphogenesis" EXACT [GOC:TermGenie] synonym: "upregulation of cardiac chamber morphogenesis" EXACT [GOC:TermGenie] synonym: "upregulation of heart chamber morphogenesis" EXACT [GOC:TermGenie] is_a: GO:0051094 ! positive regulation of developmental process is_a: GO:1901219 ! regulation of cardiac chamber morphogenesis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0003206 ! positively regulates cardiac chamber morphogenesis relationship: RO:0002213 GO:0003206 ! positively regulates cardiac chamber morphogenesis creation_date: 2012-08-06T17:59:42Z [Term] id: GO:1901246 name: regulation of lung ciliated cell differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of lung ciliated cell differentiation." [GOC:BHF, GOC:TermGenie] is_a: GO:0030856 ! regulation of epithelial cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0061141 ! regulates lung ciliated cell differentiation relationship: RO:0002211 GO:0061141 ! regulates lung ciliated cell differentiation creation_date: 2012-08-08T08:58:34Z [Term] id: GO:1901247 name: negative regulation of lung ciliated cell differentiation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of lung ciliated cell differentiation." [GOC:BHF, GOC:TermGenie] synonym: "down regulation of lung ciliated cell differentiation" EXACT [GOC:TermGenie] synonym: "down-regulation of lung ciliated cell differentiation" EXACT [GOC:TermGenie] synonym: "downregulation of lung ciliated cell differentiation" EXACT [GOC:TermGenie] synonym: "inhibition of lung ciliated cell differentiation" NARROW [GOC:TermGenie] is_a: GO:0030857 ! negative regulation of epithelial cell differentiation is_a: GO:0051241 ! negative regulation of multicellular organismal process is_a: GO:1901246 ! regulation of lung ciliated cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0061141 ! negatively regulates lung ciliated cell differentiation relationship: RO:0002212 GO:0061141 ! negatively regulates lung ciliated cell differentiation creation_date: 2012-08-08T08:58:58Z [Term] id: GO:1901248 name: positive regulation of lung ciliated cell differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of lung ciliated cell differentiation." [GOC:BHF, GOC:TermGenie] synonym: "activation of lung ciliated cell differentiation" NARROW [GOC:TermGenie] synonym: "up regulation of lung ciliated cell differentiation" EXACT [GOC:TermGenie] synonym: "up-regulation of lung ciliated cell differentiation" EXACT [GOC:TermGenie] synonym: "upregulation of lung ciliated cell differentiation" EXACT [GOC:TermGenie] is_a: GO:0030858 ! positive regulation of epithelial cell differentiation is_a: GO:0051240 ! positive regulation of multicellular organismal process is_a: GO:1901246 ! regulation of lung ciliated cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0061141 ! positively regulates lung ciliated cell differentiation relationship: RO:0002213 GO:0061141 ! positively regulates lung ciliated cell differentiation creation_date: 2012-08-08T08:59:05Z [Term] id: GO:1901249 name: regulation of lung goblet cell differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of lung goblet cell differentiation." [GOC:BHF, GOC:TermGenie] synonym: "regulation of pulmonary goblet cell differentiation" EXACT [GOC:TermGenie] is_a: GO:0030856 ! regulation of epithelial cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0060480 ! regulates lung goblet cell differentiation relationship: RO:0002211 GO:0060480 ! regulates lung goblet cell differentiation creation_date: 2012-08-08T08:59:12Z [Term] id: GO:1901250 name: negative regulation of lung goblet cell differentiation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of lung goblet cell differentiation." [GOC:BHF, GOC:TermGenie] synonym: "down regulation of lung goblet cell differentiation" EXACT [GOC:TermGenie] synonym: "down regulation of pulmonary goblet cell differentiation" EXACT [GOC:TermGenie] synonym: "down-regulation of lung goblet cell differentiation" EXACT [GOC:TermGenie] synonym: "down-regulation of pulmonary goblet cell differentiation" EXACT [GOC:TermGenie] synonym: "downregulation of lung goblet cell differentiation" EXACT [GOC:TermGenie] synonym: "downregulation of pulmonary goblet cell differentiation" EXACT [GOC:TermGenie] synonym: "inhibition of lung goblet cell differentiation" NARROW [GOC:TermGenie] synonym: "inhibition of pulmonary goblet cell differentiation" NARROW [GOC:TermGenie] synonym: "negative regulation of pulmonary goblet cell differentiation" EXACT [GOC:TermGenie] is_a: GO:0030857 ! negative regulation of epithelial cell differentiation is_a: GO:0051241 ! negative regulation of multicellular organismal process is_a: GO:1901249 ! regulation of lung goblet cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0060480 ! negatively regulates lung goblet cell differentiation relationship: RO:0002212 GO:0060480 ! negatively regulates lung goblet cell differentiation creation_date: 2012-08-08T08:59:36Z [Term] id: GO:1901251 name: positive regulation of lung goblet cell differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of lung goblet cell differentiation." [GOC:BHF, GOC:TermGenie] synonym: "activation of lung goblet cell differentiation" NARROW [GOC:TermGenie] synonym: "activation of pulmonary goblet cell differentiation" NARROW [GOC:TermGenie] synonym: "positive regulation of pulmonary goblet cell differentiation" EXACT [GOC:TermGenie] synonym: "up regulation of lung goblet cell differentiation" EXACT [GOC:TermGenie] synonym: "up regulation of pulmonary goblet cell differentiation" EXACT [GOC:TermGenie] synonym: "up-regulation of lung goblet cell differentiation" EXACT [GOC:TermGenie] synonym: "up-regulation of pulmonary goblet cell differentiation" EXACT [GOC:TermGenie] synonym: "upregulation of lung goblet cell differentiation" EXACT [GOC:TermGenie] synonym: "upregulation of pulmonary goblet cell differentiation" EXACT [GOC:TermGenie] is_a: GO:0030858 ! positive regulation of epithelial cell differentiation is_a: GO:0051240 ! positive regulation of multicellular organismal process is_a: GO:1901249 ! regulation of lung goblet cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0060480 ! positively regulates lung goblet cell differentiation relationship: RO:0002213 GO:0060480 ! positively regulates lung goblet cell differentiation creation_date: 2012-08-08T08:59:44Z [Term] id: GO:1901264 name: carbohydrate derivative transport namespace: biological_process def: "The directed movement of a carbohydrate derivative into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:bf, GOC:jl, GOC:TermGenie] is_a: BFO:0000003 is_a: GO:0006810 ! transport intersection_of: GO:0006810 ! transport intersection_of: RO:0004009 CHEBI:63299 ! has primary input relationship: RO:0004009 CHEBI:63299 ! has primary input creation_date: 2012-08-16T14:51:22Z [Term] id: GO:1901265 name: nucleoside phosphate binding namespace: molecular_function def: "Binding to nucleoside phosphate." [GOC:TermGenie] is_a: BFO:0000003 is_a: GO:0005488 ! binding intersection_of: GO:0005488 ! binding intersection_of: RO:0004009 CHEBI:25608 ! has primary input relationship: RO:0004009 CHEBI:25608 ! has primary input creation_date: 2012-08-17T12:59:58Z [Term] id: GO:1901292 name: nucleoside phosphate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of a nucleoside phosphate." [GOC:TermGenie] synonym: "nucleoside phosphate breakdown" EXACT [GOC:TermGenie] synonym: "nucleoside phosphate catabolism" EXACT [GOC:TermGenie] synonym: "nucleoside phosphate degradation" EXACT [GOC:TermGenie] is_a: GO:0006753 ! nucleoside phosphate metabolic process is_a: GO:0034655 ! nucleobase-containing compound catabolic process is_a: GO:0046434 ! organophosphate catabolic process intersection_of: GO:0009056 ! catabolic process intersection_of: RO:0004009 CHEBI:25608 ! has primary input relationship: RO:0004009 CHEBI:25608 ! has primary input creation_date: 2012-08-20T12:33:25Z [Term] id: GO:1901293 name: nucleoside phosphate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a nucleoside phosphate." [GOC:TermGenie] synonym: "nucleoside phosphate anabolism" EXACT [GOC:TermGenie] synonym: "nucleoside phosphate biosynthesis" EXACT [GOC:TermGenie] synonym: "nucleoside phosphate formation" EXACT [GOC:TermGenie] synonym: "nucleoside phosphate synthesis" EXACT [GOC:TermGenie] is_a: GO:0006753 ! nucleoside phosphate metabolic process is_a: GO:0034654 ! nucleobase-containing compound biosynthetic process is_a: GO:0090407 ! organophosphate biosynthetic process intersection_of: GO:0009058 ! biosynthetic process intersection_of: RO:0004008 CHEBI:25608 ! has primary output relationship: RO:0004008 CHEBI:25608 ! has primary output creation_date: 2012-08-20T12:33:45Z [Term] id: GO:1901317 name: regulation of flagellated sperm motility namespace: biological_process def: "Any process that modulates the frequency, rate or extent of flagellated sperm motility." [GOC:cilia, GOC:krc, GOC:TermGenie] synonym: "regulation of sperm motility" BROAD [] synonym: "regulation of sperm movement" BROAD [GOC:TermGenie] is_a: GO:0060295 ! regulation of cilium movement involved in cell motility is_a: GO:2000241 ! regulation of reproductive process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0030317 ! regulates flagellated sperm motility relationship: RO:0002211 GO:0030317 ! regulates flagellated sperm motility property_value: RO:0002161 NCBITaxon:3176 property_value: RO:0002161 NCBITaxon:3378 property_value: RO:0002161 NCBITaxon:3398 property_value: RO:0002161 NCBITaxon:451864 property_value: RO:0002161 NCBITaxon:5782 creation_date: 2012-08-22T20:50:14Z [Term] id: GO:1901318 name: negative regulation of flagellated sperm motility namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of flagellated sperm motility." [GOC:cilia, GOC:krc, GOC:TermGenie] synonym: "down regulation of sperm motility" BROAD [GOC:TermGenie] synonym: "down regulation of sperm movement" BROAD [GOC:TermGenie] synonym: "down-regulation of sperm motility" BROAD [GOC:TermGenie] synonym: "down-regulation of sperm movement" BROAD [GOC:TermGenie] synonym: "downregulation of sperm motility" BROAD [GOC:TermGenie] synonym: "downregulation of sperm movement" BROAD [GOC:TermGenie] synonym: "inhibition of sperm motility" NARROW [GOC:TermGenie] synonym: "inhibition of sperm movement" BROAD [GOC:TermGenie] synonym: "negative regulation of sperm motility" BROAD [] synonym: "negative regulation of sperm movement" BROAD [GOC:TermGenie] is_a: GO:0003354 ! negative regulation of cilium movement is_a: GO:1901317 ! regulation of flagellated sperm motility is_a: GO:1902020 ! negative regulation of cilium-dependent cell motility is_a: GO:2000242 ! negative regulation of reproductive process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0030317 ! negatively regulates flagellated sperm motility relationship: RO:0002212 GO:0030317 ! negatively regulates flagellated sperm motility property_value: RO:0002161 NCBITaxon:3176 property_value: RO:0002161 NCBITaxon:3378 property_value: RO:0002161 NCBITaxon:3398 property_value: RO:0002161 NCBITaxon:451864 property_value: RO:0002161 NCBITaxon:5782 creation_date: 2012-08-22T20:50:35Z [Term] id: GO:1901329 name: regulation of odontoblast differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of odontoblast differentiation." [GOC:TermGenie] is_a: GO:0030856 ! regulation of epithelial cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0071895 ! regulates odontoblast differentiation relationship: RO:0002211 GO:0071895 ! regulates odontoblast differentiation creation_date: 2012-08-31T16:50:05Z [Term] id: GO:1901330 name: negative regulation of odontoblast differentiation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of odontoblast differentiation." [GOC:TermGenie] synonym: "down regulation of odontoblast differentiation" EXACT [GOC:TermGenie] synonym: "down-regulation of odontoblast differentiation" EXACT [GOC:TermGenie] synonym: "downregulation of odontoblast differentiation" EXACT [GOC:TermGenie] synonym: "inhibition of odontoblast differentiation" NARROW [GOC:TermGenie] is_a: GO:0002085 ! inhibition of neuroepithelial cell differentiation is_a: GO:1901329 ! regulation of odontoblast differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0071895 ! negatively regulates odontoblast differentiation relationship: RO:0002212 GO:0071895 ! negatively regulates odontoblast differentiation creation_date: 2012-08-31T16:50:27Z [Term] id: GO:1901331 name: positive regulation of odontoblast differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of odontoblast differentiation." [GOC:TermGenie] synonym: "activation of odontoblast differentiation" NARROW [GOC:TermGenie] synonym: "up regulation of odontoblast differentiation" EXACT [GOC:TermGenie] synonym: "up-regulation of odontoblast differentiation" EXACT [GOC:TermGenie] synonym: "upregulation of odontoblast differentiation" EXACT [GOC:TermGenie] is_a: GO:1901329 ! regulation of odontoblast differentiation is_a: GO:1902913 ! positive regulation of neuroepithelial cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0071895 ! positively regulates odontoblast differentiation relationship: RO:0002213 GO:0071895 ! positively regulates odontoblast differentiation creation_date: 2012-08-31T16:50:35Z [Term] id: GO:1901338 name: catecholamine binding namespace: molecular_function def: "Binding to catecholamine." [GOC:TermGenie] is_a: BFO:0000003 is_a: GO:0005488 ! binding intersection_of: GO:0005488 ! binding intersection_of: RO:0004009 CHEBI:33567 ! has primary input relationship: RO:0004009 CHEBI:33567 ! has primary input creation_date: 2012-09-03T14:08:44Z [Term] id: GO:1901342 name: regulation of vasculature development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of vasculature development." [GOC:TermGenie] synonym: "regulation of vascular system development" RELATED [GOC:TermGenie] is_a: GO:2000026 ! regulation of multicellular organismal development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0001944 ! regulates vasculature development relationship: RO:0002211 GO:0001944 ! regulates vasculature development creation_date: 2012-09-06T09:16:15Z [Term] id: GO:1901343 name: negative regulation of vasculature development namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of vasculature development." [GOC:TermGenie] synonym: "down regulation of vascular system development" RELATED [GOC:TermGenie] synonym: "down regulation of vasculature development" EXACT [GOC:TermGenie] synonym: "down-regulation of vascular system development" RELATED [GOC:TermGenie] synonym: "down-regulation of vasculature development" EXACT [GOC:TermGenie] synonym: "downregulation of vascular system development" RELATED [GOC:TermGenie] synonym: "downregulation of vasculature development" EXACT [GOC:TermGenie] synonym: "inhibition of vascular system development" RELATED [GOC:TermGenie] synonym: "inhibition of vasculature development" NARROW [GOC:TermGenie] synonym: "negative regulation of vascular system development" RELATED [GOC:TermGenie] is_a: GO:0051093 ! negative regulation of developmental process is_a: GO:0051241 ! negative regulation of multicellular organismal process is_a: GO:1901342 ! regulation of vasculature development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0001944 ! negatively regulates vasculature development relationship: RO:0002212 GO:0001944 ! negatively regulates vasculature development creation_date: 2012-09-06T09:17:24Z [Term] id: GO:1901363 name: heterocyclic compound binding namespace: molecular_function def: "Binding to heterocyclic compound." [GOC:TermGenie] is_a: BFO:0000003 is_a: GO:0036094 ! small molecule binding intersection_of: GO:0036094 ! small molecule binding intersection_of: RO:0004009 CHEBI:5686 ! has primary input relationship: RO:0004009 CHEBI:5686 ! has primary input creation_date: 2012-09-14T13:53:50Z [Term] id: GO:1901374 name: acetate ester transport namespace: biological_process def: "The directed movement of an acetate ester into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:TermGenie] is_a: BFO:0000003 is_a: GO:0006810 ! transport intersection_of: GO:0006810 ! transport intersection_of: RO:0004009 CHEBI:47622 ! has primary input relationship: RO:0004009 CHEBI:47622 ! has primary input creation_date: 2012-09-28T10:42:13Z [Term] id: GO:1901375 name: acetate ester transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of an acetate ester from one side of a membrane to the other." [GOC:TermGenie] is_a: GO:0022857 ! transmembrane transporter activity intersection_of: GO:0022857 ! transmembrane transporter activity intersection_of: RO:0004009 CHEBI:47622 ! has primary input relationship: BFO:0000050 GO:1901374 ! part of acetate ester transport relationship: RO:0004009 CHEBI:47622 ! has primary input creation_date: 2012-09-28T10:47:08Z [Term] id: GO:1901379 name: regulation of potassium ion transmembrane transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of potassium ion transmembrane transport." [GOC:BHF, GOC:TermGenie] synonym: "regulation of potassium ion membrane transport" EXACT [] is_a: GO:0043266 ! regulation of potassium ion transport is_a: GO:1904062 ! regulation of monoatomic cation transmembrane transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0071805 ! regulates potassium ion transmembrane transport relationship: RO:0002211 GO:0071805 ! regulates potassium ion transmembrane transport creation_date: 2012-09-28T15:58:00Z [Term] id: GO:1901380 name: negative regulation of potassium ion transmembrane transport namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of potassium ion transmembrane transport." [GOC:BHF, GOC:TermGenie] synonym: "down regulation of potassium ion transmembrane transport" EXACT [GOC:TermGenie] synonym: "down-regulation of potassium ion transmembrane transport" EXACT [GOC:TermGenie] synonym: "downregulation of potassium ion transmembrane transport" EXACT [GOC:TermGenie] synonym: "inhibition of potassium ion transmembrane transport" NARROW [GOC:TermGenie] synonym: "negative regulation of potassium ion membrane transport" EXACT [] is_a: GO:0043267 ! negative regulation of potassium ion transport is_a: GO:1901379 ! regulation of potassium ion transmembrane transport is_a: GO:1904063 ! negative regulation of cation transmembrane transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0071805 ! negatively regulates potassium ion transmembrane transport relationship: RO:0002212 GO:0071805 ! negatively regulates potassium ion transmembrane transport creation_date: 2012-09-28T15:59:08Z [Term] id: GO:1901381 name: positive regulation of potassium ion transmembrane transport namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of potassium ion transmembrane transport." [GOC:BHF, GOC:TermGenie] synonym: "activation of potassium ion transmembrane transport" NARROW [GOC:TermGenie] synonym: "positive regulation of potassium ion membrane transport" EXACT [] synonym: "up regulation of potassium ion transmembrane transport" EXACT [GOC:TermGenie] synonym: "up-regulation of potassium ion transmembrane transport" EXACT [GOC:TermGenie] synonym: "upregulation of potassium ion transmembrane transport" EXACT [GOC:TermGenie] xref: Reactome:R-HSA-1296041 "Activation of G protein gated Potassium channels" xref: Reactome:R-HSA-1296052 "Ca2+ activated K+ channels" is_a: GO:0043268 ! positive regulation of potassium ion transport is_a: GO:1901379 ! regulation of potassium ion transmembrane transport is_a: GO:1904064 ! positive regulation of cation transmembrane transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0071805 ! positively regulates potassium ion transmembrane transport relationship: RO:0002213 GO:0071805 ! positively regulates potassium ion transmembrane transport creation_date: 2012-09-28T15:59:25Z [Term] id: GO:1901382 name: regulation of chorionic trophoblast cell proliferation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of chorionic trophoblast cell proliferation." [GOC:BHF, GOC:TermGenie] is_a: GO:0042127 ! regulation of cell population proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0097360 ! regulates chorionic trophoblast cell proliferation relationship: RO:0002211 GO:0097360 ! regulates chorionic trophoblast cell proliferation property_value: RO:0002161 NCBITaxon:4751 creation_date: 2012-10-01T10:03:13Z [Term] id: GO:1901383 name: negative regulation of chorionic trophoblast cell proliferation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of chorionic trophoblast cell proliferation." [GOC:BHF, GOC:TermGenie] synonym: "down regulation of chorionic trophoblast cell proliferation" EXACT [GOC:TermGenie] synonym: "down-regulation of chorionic trophoblast cell proliferation" EXACT [GOC:TermGenie] synonym: "downregulation of chorionic trophoblast cell proliferation" EXACT [GOC:TermGenie] synonym: "inhibition of chorionic trophoblast cell proliferation" NARROW [GOC:TermGenie] is_a: GO:0008285 ! negative regulation of cell population proliferation is_a: GO:1901382 ! regulation of chorionic trophoblast cell proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0097360 ! negatively regulates chorionic trophoblast cell proliferation relationship: RO:0002212 GO:0097360 ! negatively regulates chorionic trophoblast cell proliferation property_value: RO:0002161 NCBITaxon:4751 creation_date: 2012-10-01T10:04:23Z [Term] id: GO:1901384 name: positive regulation of chorionic trophoblast cell proliferation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of chorionic trophoblast cell proliferation." [GOC:BHF, GOC:TermGenie] synonym: "activation of chorionic trophoblast cell proliferation" NARROW [GOC:TermGenie] synonym: "up regulation of chorionic trophoblast cell proliferation" EXACT [GOC:TermGenie] synonym: "up-regulation of chorionic trophoblast cell proliferation" EXACT [GOC:TermGenie] synonym: "upregulation of chorionic trophoblast cell proliferation" EXACT [GOC:TermGenie] is_a: GO:0008284 ! positive regulation of cell population proliferation is_a: GO:1901382 ! regulation of chorionic trophoblast cell proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0097360 ! positively regulates chorionic trophoblast cell proliferation relationship: RO:0002213 GO:0097360 ! positively regulates chorionic trophoblast cell proliferation property_value: RO:0002161 NCBITaxon:4751 creation_date: 2012-10-01T10:04:41Z [Term] id: GO:1901385 name: regulation of voltage-gated calcium channel activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of voltage-gated calcium channel activity." [GOC:BHF, GOC:TermGenie] subset: gocheck_obsoletion_candidate synonym: "regulation of depolarization-activated calcium channel" BROAD [GOC:TermGenie] synonym: "regulation of depolarization-activated voltage gated calcium channel activity" EXACT [GOC:TermGenie] synonym: "regulation of depolarization-activated voltage-gated calcium channel" EXACT [GOC:TermGenie] synonym: "regulation of depolarization-activated voltage-gated calcium channel activity" EXACT [GOC:TermGenie] synonym: "regulation of dihydropyridine-sensitive calcium channel activity" NARROW [GOC:TermGenie] synonym: "regulation of voltage gated calcium channel activity" EXACT [GOC:TermGenie] synonym: "regulation of voltage-dependent calcium channel activity" EXACT [GOC:TermGenie] synonym: "regulation of voltage-gated calcium ion channel activity" EXACT [GOC:TermGenie] synonym: "regulation of voltage-sensitive calcium channel" EXACT [GOC:TermGenie] is_a: GO:0022898 ! regulation of transmembrane transporter activity intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0005245 ! regulates voltage-gated calcium channel activity relationship: RO:0002211 GO:0005245 ! regulates voltage-gated calcium channel activity creation_date: 2012-10-01T10:34:08Z [Term] id: GO:1901386 name: negative regulation of voltage-gated calcium channel activity namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of voltage-gated calcium channel activity." [GOC:BHF, GOC:TermGenie] subset: gocheck_obsoletion_candidate synonym: "down regulation of depolarization-activated calcium channel" BROAD [GOC:TermGenie] synonym: "down regulation of depolarization-activated voltage gated calcium channel activity" EXACT [GOC:TermGenie] synonym: "down regulation of depolarization-activated voltage-gated calcium channel" EXACT [GOC:TermGenie] synonym: "down regulation of depolarization-activated voltage-gated calcium channel activity" EXACT [GOC:TermGenie] synonym: "down regulation of dihydropyridine-sensitive calcium channel activity" NARROW [GOC:TermGenie] synonym: "down regulation of voltage gated calcium channel activity" EXACT [GOC:TermGenie] synonym: "down regulation of voltage-dependent calcium channel activity" EXACT [GOC:TermGenie] synonym: "down regulation of voltage-gated calcium channel activity" EXACT [GOC:TermGenie] synonym: "down regulation of voltage-gated calcium ion channel activity" EXACT [GOC:TermGenie] synonym: "down regulation of voltage-sensitive calcium channel" EXACT [GOC:TermGenie] synonym: "down-regulation of depolarization-activated calcium channel" BROAD [GOC:TermGenie] synonym: "down-regulation of depolarization-activated voltage gated calcium channel activity" EXACT [GOC:TermGenie] synonym: "down-regulation of depolarization-activated voltage-gated calcium channel" EXACT [GOC:TermGenie] synonym: "down-regulation of depolarization-activated voltage-gated calcium channel activity" EXACT [GOC:TermGenie] synonym: "down-regulation of dihydropyridine-sensitive calcium channel activity" NARROW [GOC:TermGenie] synonym: "down-regulation of voltage gated calcium channel activity" EXACT [GOC:TermGenie] synonym: "down-regulation of voltage-dependent calcium channel activity" EXACT [GOC:TermGenie] synonym: "down-regulation of voltage-gated calcium channel activity" EXACT [GOC:TermGenie] synonym: "down-regulation of voltage-gated calcium ion channel activity" EXACT [GOC:TermGenie] synonym: "down-regulation of voltage-sensitive calcium channel" EXACT [GOC:TermGenie] synonym: "downregulation of depolarization-activated calcium channel" BROAD [GOC:TermGenie] synonym: "downregulation of depolarization-activated voltage gated calcium channel activity" EXACT [GOC:TermGenie] synonym: "downregulation of depolarization-activated voltage-gated calcium channel" EXACT [GOC:TermGenie] synonym: "downregulation of depolarization-activated voltage-gated calcium channel activity" EXACT [GOC:TermGenie] synonym: "downregulation of dihydropyridine-sensitive calcium channel activity" NARROW [GOC:TermGenie] synonym: "downregulation of voltage gated calcium channel activity" EXACT [GOC:TermGenie] synonym: "downregulation of voltage-dependent calcium channel activity" EXACT [GOC:TermGenie] synonym: "downregulation of voltage-gated calcium channel activity" EXACT [GOC:TermGenie] synonym: "downregulation of voltage-gated calcium ion channel activity" EXACT [GOC:TermGenie] synonym: "downregulation of voltage-sensitive calcium channel" EXACT [GOC:TermGenie] synonym: "inhibition of depolarization-activated calcium channel" BROAD [GOC:TermGenie] synonym: "inhibition of depolarization-activated voltage gated calcium channel activity" EXACT [GOC:TermGenie] synonym: "inhibition of depolarization-activated voltage-gated calcium channel" EXACT [GOC:TermGenie] synonym: "inhibition of depolarization-activated voltage-gated calcium channel activity" EXACT [GOC:TermGenie] synonym: "inhibition of dihydropyridine-sensitive calcium channel activity" NARROW [GOC:TermGenie] synonym: "inhibition of voltage gated calcium channel activity" EXACT [GOC:TermGenie] synonym: "inhibition of voltage-dependent calcium channel activity" EXACT [GOC:TermGenie] synonym: "inhibition of voltage-gated calcium channel activity" NARROW [GOC:TermGenie] synonym: "inhibition of voltage-gated calcium ion channel activity" EXACT [GOC:TermGenie] synonym: "inhibition of voltage-sensitive calcium channel" EXACT [GOC:TermGenie] synonym: "negative regulation of depolarization-activated calcium channel" BROAD [GOC:TermGenie] synonym: "negative regulation of depolarization-activated voltage gated calcium channel activity" EXACT [GOC:TermGenie] synonym: "negative regulation of depolarization-activated voltage-gated calcium channel" EXACT [GOC:TermGenie] synonym: "negative regulation of depolarization-activated voltage-gated calcium channel activity" EXACT [GOC:TermGenie] synonym: "negative regulation of dihydropyridine-sensitive calcium channel activity" NARROW [GOC:TermGenie] synonym: "negative regulation of voltage gated calcium channel activity" EXACT [GOC:TermGenie] synonym: "negative regulation of voltage-dependent calcium channel activity" EXACT [GOC:TermGenie] synonym: "negative regulation of voltage-gated calcium ion channel activity" EXACT [GOC:TermGenie] synonym: "negative regulation of voltage-sensitive calcium channel" EXACT [GOC:TermGenie] is_a: GO:1901020 ! negative regulation of calcium ion transmembrane transporter activity is_a: GO:1901385 ! regulation of voltage-gated calcium channel activity intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0005245 ! negatively regulates voltage-gated calcium channel activity relationship: RO:0002212 GO:0005245 ! negatively regulates voltage-gated calcium channel activity creation_date: 2012-10-01T10:35:15Z [Term] id: GO:1901387 name: positive regulation of voltage-gated calcium channel activity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of voltage-gated calcium channel activity." [GOC:BHF, GOC:TermGenie] subset: gocheck_obsoletion_candidate synonym: "activation of depolarization-activated calcium channel" BROAD [GOC:TermGenie] synonym: "activation of depolarization-activated voltage gated calcium channel activity" EXACT [GOC:TermGenie] synonym: "activation of depolarization-activated voltage-gated calcium channel" EXACT [GOC:TermGenie] synonym: "activation of depolarization-activated voltage-gated calcium channel activity" EXACT [GOC:TermGenie] synonym: "activation of dihydropyridine-sensitive calcium channel activity" NARROW [GOC:TermGenie] synonym: "activation of voltage gated calcium channel activity" EXACT [GOC:TermGenie] synonym: "activation of voltage-dependent calcium channel activity" EXACT [GOC:TermGenie] synonym: "activation of voltage-gated calcium channel activity" NARROW [GOC:TermGenie] synonym: "activation of voltage-gated calcium ion channel activity" EXACT [GOC:TermGenie] synonym: "activation of voltage-sensitive calcium channel" EXACT [GOC:TermGenie] synonym: "positive regulation of depolarization-activated calcium channel" BROAD [GOC:TermGenie] synonym: "positive regulation of depolarization-activated voltage gated calcium channel activity" EXACT [GOC:TermGenie] synonym: "positive regulation of depolarization-activated voltage-gated calcium channel" EXACT [GOC:TermGenie] synonym: "positive regulation of depolarization-activated voltage-gated calcium channel activity" EXACT [GOC:TermGenie] synonym: "positive regulation of dihydropyridine-sensitive calcium channel activity" NARROW [GOC:TermGenie] synonym: "positive regulation of voltage gated calcium channel activity" EXACT [GOC:TermGenie] synonym: "positive regulation of voltage-dependent calcium channel activity" EXACT [GOC:TermGenie] synonym: "positive regulation of voltage-gated calcium ion channel activity" EXACT [GOC:TermGenie] synonym: "positive regulation of voltage-sensitive calcium channel" EXACT [GOC:TermGenie] synonym: "up regulation of depolarization-activated calcium channel" BROAD [GOC:TermGenie] synonym: "up regulation of depolarization-activated voltage gated calcium channel activity" EXACT [GOC:TermGenie] synonym: "up regulation of depolarization-activated voltage-gated calcium channel" EXACT [GOC:TermGenie] synonym: "up regulation of depolarization-activated voltage-gated calcium channel activity" EXACT [GOC:TermGenie] synonym: "up regulation of dihydropyridine-sensitive calcium channel activity" NARROW [GOC:TermGenie] synonym: "up regulation of voltage gated calcium channel activity" EXACT [GOC:TermGenie] synonym: "up regulation of voltage-dependent calcium channel activity" EXACT [GOC:TermGenie] synonym: "up regulation of voltage-gated calcium channel activity" EXACT [GOC:TermGenie] synonym: "up regulation of voltage-gated calcium ion channel activity" EXACT [GOC:TermGenie] synonym: "up regulation of voltage-sensitive calcium channel" EXACT [GOC:TermGenie] synonym: "up-regulation of depolarization-activated calcium channel" BROAD [GOC:TermGenie] synonym: "up-regulation of depolarization-activated voltage gated calcium channel activity" EXACT [GOC:TermGenie] synonym: "up-regulation of depolarization-activated voltage-gated calcium channel" EXACT [GOC:TermGenie] synonym: "up-regulation of depolarization-activated voltage-gated calcium channel activity" EXACT [GOC:TermGenie] synonym: "up-regulation of dihydropyridine-sensitive calcium channel activity" NARROW [GOC:TermGenie] synonym: "up-regulation of voltage gated calcium channel activity" EXACT [GOC:TermGenie] synonym: "up-regulation of voltage-dependent calcium channel activity" EXACT [GOC:TermGenie] synonym: "up-regulation of voltage-gated calcium channel activity" EXACT [GOC:TermGenie] synonym: "up-regulation of voltage-gated calcium ion channel activity" EXACT [GOC:TermGenie] synonym: "up-regulation of voltage-sensitive calcium channel" EXACT [GOC:TermGenie] synonym: "upregulation of depolarization-activated calcium channel" BROAD [GOC:TermGenie] synonym: "upregulation of depolarization-activated voltage gated calcium channel activity" EXACT [GOC:TermGenie] synonym: "upregulation of depolarization-activated voltage-gated calcium channel" EXACT [GOC:TermGenie] synonym: "upregulation of depolarization-activated voltage-gated calcium channel activity" EXACT [GOC:TermGenie] synonym: "upregulation of dihydropyridine-sensitive calcium channel activity" NARROW [GOC:TermGenie] synonym: "upregulation of voltage gated calcium channel activity" EXACT [GOC:TermGenie] synonym: "upregulation of voltage-dependent calcium channel activity" EXACT [GOC:TermGenie] synonym: "upregulation of voltage-gated calcium channel activity" EXACT [GOC:TermGenie] synonym: "upregulation of voltage-gated calcium ion channel activity" EXACT [GOC:TermGenie] synonym: "upregulation of voltage-sensitive calcium channel" EXACT [GOC:TermGenie] is_a: GO:1901385 ! regulation of voltage-gated calcium channel activity is_a: GO:2001259 ! positive regulation of cation channel activity intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0005245 ! positively regulates voltage-gated calcium channel activity relationship: RO:0002213 GO:0005245 ! positively regulates voltage-gated calcium channel activity creation_date: 2012-10-01T10:35:32Z [Term] id: GO:1901419 name: regulation of response to alcohol namespace: biological_process def: "Any process that modulates the frequency, rate or extent of response to alcohol." [GOC:mengo_curators, GOC:TermGenie] is_a: GO:0048583 ! regulation of response to stimulus intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0097305 ! regulates response to alcohol relationship: RO:0002211 GO:0097305 ! regulates response to alcohol creation_date: 2012-10-01T16:52:13Z [Term] id: GO:1901420 name: negative regulation of response to alcohol namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of response to alcohol." [GOC:mengo_curators, GOC:TermGenie] synonym: "down regulation of response to alcohol" EXACT [GOC:TermGenie] synonym: "down-regulation of response to alcohol" EXACT [GOC:TermGenie] synonym: "downregulation of response to alcohol" EXACT [GOC:TermGenie] synonym: "inhibition of response to alcohol" NARROW [GOC:TermGenie] is_a: GO:0048585 ! negative regulation of response to stimulus is_a: GO:1901419 ! regulation of response to alcohol intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0097305 ! negatively regulates response to alcohol relationship: RO:0002212 GO:0097305 ! negatively regulates response to alcohol creation_date: 2012-10-01T16:53:25Z [Term] id: GO:1901421 name: positive regulation of response to alcohol namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of response to alcohol." [GOC:mengo_curators, GOC:TermGenie] synonym: "activation of response to alcohol" NARROW [GOC:TermGenie] synonym: "up regulation of response to alcohol" EXACT [GOC:TermGenie] synonym: "up-regulation of response to alcohol" EXACT [GOC:TermGenie] synonym: "upregulation of response to alcohol" EXACT [GOC:TermGenie] is_a: GO:0048584 ! positive regulation of response to stimulus is_a: GO:1901419 ! regulation of response to alcohol intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0097305 ! positively regulates response to alcohol relationship: RO:0002213 GO:0097305 ! positively regulates response to alcohol creation_date: 2012-10-01T16:53:42Z [Term] id: GO:1901472 name: regulation of Golgi calcium ion export namespace: biological_process def: "Any process that modulates the frequency, rate or extent of Golgi calcium ion export." [GOC:TermGenie] is_a: GO:0051279 ! regulation of release of sequestered calcium ion into cytosol intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0061454 ! regulates release of sequestered calcium ion into cytosol by Golgi relationship: RO:0002211 GO:0061454 ! regulates release of sequestered calcium ion into cytosol by Golgi creation_date: 2012-10-03T07:26:03Z [Term] id: GO:1901474 name: azole transmembrane transporter activity namespace: molecular_function def: "Enables the directed movement of azoles, heterocyclic compound found in many biologically important substances, from one side of a membrane to the other." [GOC:go_curators, ISBN:3527307206, Wikipedia:Azole] synonym: "azole transporter activity" RELATED [] is_a: GO:0022857 ! transmembrane transporter activity intersection_of: GO:0022857 ! transmembrane transporter activity intersection_of: RO:0004009 CHEBI:68452 ! has primary input relationship: BFO:0000050 GO:0045117 ! part of azole transmembrane transport relationship: RO:0004009 CHEBI:68452 ! has primary input creation_date: 2012-10-04T20:00:27Z [Term] id: GO:1901490 name: regulation of lymphangiogenesis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of lymphangiogenesis." [GOC:dph, GOC:TermGenie, PMID:20133819] synonym: "regulation of lymph vessel formation" EXACT [GOC:TermGenie] is_a: GO:0022603 ! regulation of anatomical structure morphogenesis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0001946 ! regulates lymphangiogenesis relationship: RO:0002211 GO:0001946 ! regulates lymphangiogenesis creation_date: 2012-10-15T13:08:17Z [Term] id: GO:1901491 name: negative regulation of lymphangiogenesis namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of lymphangiogenesis." [GOC:dph, GOC:TermGenie, PMID:20133819] synonym: "down regulation of lymph vessel formation" EXACT [GOC:TermGenie] synonym: "down regulation of lymphangiogenesis" EXACT [GOC:TermGenie] synonym: "down-regulation of lymph vessel formation" EXACT [GOC:TermGenie] synonym: "down-regulation of lymphangiogenesis" EXACT [GOC:TermGenie] synonym: "downregulation of lymph vessel formation" EXACT [GOC:TermGenie] synonym: "downregulation of lymphangiogenesis" EXACT [GOC:TermGenie] synonym: "inhibition of lymph vessel formation" NARROW [GOC:TermGenie] synonym: "inhibition of lymphangiogenesis" NARROW [GOC:TermGenie] synonym: "negative regulation of lymph vessel formation" EXACT [GOC:TermGenie] is_a: GO:0051093 ! negative regulation of developmental process is_a: GO:1901490 ! regulation of lymphangiogenesis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0001946 ! negatively regulates lymphangiogenesis relationship: RO:0002212 GO:0001946 ! negatively regulates lymphangiogenesis creation_date: 2012-10-15T13:08:21Z [Term] id: GO:1901492 name: positive regulation of lymphangiogenesis namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of lymphangiogenesis." [GOC:dph, GOC:TermGenie, PMID:20133819] synonym: "activation of lymph vessel formation" NARROW [GOC:TermGenie] synonym: "activation of lymphangiogenesis" NARROW [GOC:TermGenie] synonym: "positive regulation of lymph vessel formation" EXACT [GOC:TermGenie] synonym: "up regulation of lymph vessel formation" EXACT [GOC:TermGenie] synonym: "up regulation of lymphangiogenesis" EXACT [GOC:TermGenie] synonym: "up-regulation of lymph vessel formation" EXACT [GOC:TermGenie] synonym: "up-regulation of lymphangiogenesis" EXACT [GOC:TermGenie] synonym: "upregulation of lymph vessel formation" EXACT [GOC:TermGenie] synonym: "upregulation of lymphangiogenesis" EXACT [GOC:TermGenie] is_a: GO:0051094 ! positive regulation of developmental process is_a: GO:1901490 ! regulation of lymphangiogenesis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0001946 ! positively regulates lymphangiogenesis relationship: RO:0002213 GO:0001946 ! positively regulates lymphangiogenesis creation_date: 2012-10-15T13:08:25Z [Term] id: GO:1901505 name: carbohydrate derivative transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of carbohydrate derivative from one side of a membrane to the other." [GOC:pr, GOC:TermGenie] synonym: "carbohydrate derivative transporter activity" RELATED [] is_a: GO:0022857 ! transmembrane transporter activity intersection_of: GO:0022857 ! transmembrane transporter activity intersection_of: RO:0004009 CHEBI:63299 ! has primary input relationship: BFO:0000050 GO:1901264 {source="GO_REF:0000090"} ! part of carbohydrate derivative transport relationship: RO:0004009 CHEBI:63299 ! has primary input creation_date: 2012-10-17T10:31:22Z [Term] id: GO:1901509 name: regulation of endothelial tube morphogenesis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of endothelial tube morphogenesis." [GOC:dph, GOC:TermGenie] is_a: GO:1905330 ! regulation of morphogenesis of an epithelium intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0061154 ! regulates endothelial tube morphogenesis relationship: RO:0002211 GO:0061154 ! regulates endothelial tube morphogenesis creation_date: 2012-10-17T14:30:40Z [Term] id: GO:1901532 name: regulation of hematopoietic progenitor cell differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of hematopoietic progenitor cell differentiation." [GOC:BHF, GOC:rl, GOC:TermGenie] synonym: "regulation of haematopoietic progenitor cell differentiation" EXACT [GOC:TermGenie] synonym: "regulation of haemopoietic progenitor cell differentiation" EXACT [GOC:TermGenie] synonym: "regulation of hemopoietic progenitor cell differentiation" EXACT [] is_a: GO:0045595 ! regulation of cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0002244 ! regulates hematopoietic progenitor cell differentiation relationship: RO:0002211 GO:0002244 ! regulates hematopoietic progenitor cell differentiation creation_date: 2012-10-24T11:23:01Z [Term] id: GO:1901533 name: negative regulation of hematopoietic progenitor cell differentiation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of hematopoietic progenitor cell differentiation." [GOC:BHF, GOC:rl, GOC:TermGenie] synonym: "down regulation of haematopoietic progenitor cell differentiation" EXACT [GOC:TermGenie] synonym: "down regulation of haemopoietic progenitor cell differentiation" EXACT [GOC:TermGenie] synonym: "down regulation of hematopoietic progenitor cell differentiation" RELATED [GOC:TermGenie] synonym: "down regulation of hemopoietic progenitor cell differentiation" EXACT [GOC:TermGenie] synonym: "down-regulation of haematopoietic progenitor cell differentiation" EXACT [GOC:TermGenie] synonym: "down-regulation of haemopoietic progenitor cell differentiation" EXACT [GOC:TermGenie] synonym: "down-regulation of hematopoietic progenitor cell differentiation" RELATED [GOC:TermGenie] synonym: "down-regulation of hemopoietic progenitor cell differentiation" EXACT [GOC:TermGenie] synonym: "downregulation of haematopoietic progenitor cell differentiation" EXACT [GOC:TermGenie] synonym: "downregulation of haemopoietic progenitor cell differentiation" EXACT [GOC:TermGenie] synonym: "downregulation of hematopoietic progenitor cell differentiation" RELATED [GOC:TermGenie] synonym: "downregulation of hemopoietic progenitor cell differentiation" EXACT [GOC:TermGenie] synonym: "inhibition of haematopoietic progenitor cell differentiation" EXACT [GOC:TermGenie] synonym: "inhibition of haemopoietic progenitor cell differentiation" EXACT [GOC:TermGenie] synonym: "inhibition of hematopoietic progenitor cell differentiation" RELATED [GOC:TermGenie] synonym: "inhibition of hemopoietic progenitor cell differentiation" NARROW [GOC:TermGenie] synonym: "negative regulation of haematopoietic progenitor cell differentiation" EXACT [GOC:TermGenie] synonym: "negative regulation of haemopoietic progenitor cell differentiation" EXACT [GOC:TermGenie] synonym: "negative regulation of hemopoietic progenitor cell differentiation" EXACT [] is_a: GO:0045596 ! negative regulation of cell differentiation is_a: GO:1901532 ! regulation of hematopoietic progenitor cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0002244 ! negatively regulates hematopoietic progenitor cell differentiation relationship: RO:0002212 GO:0002244 ! negatively regulates hematopoietic progenitor cell differentiation creation_date: 2012-10-24T11:23:06Z [Term] id: GO:1901534 name: positive regulation of hematopoietic progenitor cell differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of hematopoietic progenitor cell differentiation." [GOC:BHF, GOC:rl, GOC:TermGenie] synonym: "activation of haematopoietic progenitor cell differentiation" EXACT [GOC:TermGenie] synonym: "activation of haemopoietic progenitor cell differentiation" EXACT [GOC:TermGenie] synonym: "activation of hematopoietic progenitor cell differentiation" RELATED [GOC:TermGenie] synonym: "activation of hemopoietic progenitor cell differentiation" NARROW [GOC:TermGenie] synonym: "positive regulation of haematopoietic progenitor cell differentiation" EXACT [GOC:TermGenie] synonym: "positive regulation of haemopoietic progenitor cell differentiation" EXACT [GOC:TermGenie] synonym: "positive regulation of hemopoietic progenitor cell differentiation" EXACT [] synonym: "up regulation of haematopoietic progenitor cell differentiation" EXACT [GOC:TermGenie] synonym: "up regulation of haemopoietic progenitor cell differentiation" EXACT [GOC:TermGenie] synonym: "up regulation of hematopoietic progenitor cell differentiation" RELATED [GOC:TermGenie] synonym: "up regulation of hemopoietic progenitor cell differentiation" EXACT [GOC:TermGenie] synonym: "up-regulation of haematopoietic progenitor cell differentiation" EXACT [GOC:TermGenie] synonym: "up-regulation of haemopoietic progenitor cell differentiation" EXACT [GOC:TermGenie] synonym: "up-regulation of hematopoietic progenitor cell differentiation" RELATED [GOC:TermGenie] synonym: "up-regulation of hemopoietic progenitor cell differentiation" EXACT [GOC:TermGenie] synonym: "upregulation of haematopoietic progenitor cell differentiation" EXACT [GOC:TermGenie] synonym: "upregulation of haemopoietic progenitor cell differentiation" EXACT [GOC:TermGenie] synonym: "upregulation of hematopoietic progenitor cell differentiation" RELATED [GOC:TermGenie] synonym: "upregulation of hemopoietic progenitor cell differentiation" EXACT [GOC:TermGenie] is_a: GO:0045597 ! positive regulation of cell differentiation is_a: GO:1901532 ! regulation of hematopoietic progenitor cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0002244 ! positively regulates hematopoietic progenitor cell differentiation relationship: RO:0002213 GO:0002244 ! positively regulates hematopoietic progenitor cell differentiation creation_date: 2012-10-24T11:23:14Z [Term] id: GO:1901550 name: regulation of endothelial cell development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of endothelial cell development." [GOC:pr, GOC:TermGenie, PMID:19470579] is_a: GO:0045601 ! regulation of endothelial cell differentiation is_a: GO:0060284 ! regulation of cell development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0001885 ! regulates endothelial cell development relationship: RO:0002211 GO:0001885 ! regulates endothelial cell development creation_date: 2012-10-30T12:59:50Z [Term] id: GO:1901551 name: negative regulation of endothelial cell development namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of endothelial cell development." [GOC:pr, GOC:TermGenie, PMID:19470579] synonym: "down regulation of endothelial cell development" EXACT [GOC:TermGenie] synonym: "down-regulation of endothelial cell development" EXACT [GOC:TermGenie] synonym: "downregulation of endothelial cell development" EXACT [GOC:TermGenie] synonym: "inhibition of endothelial cell development" NARROW [GOC:TermGenie] is_a: GO:0010721 ! negative regulation of cell development is_a: GO:0045602 ! negative regulation of endothelial cell differentiation is_a: GO:1901550 ! regulation of endothelial cell development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0001885 ! negatively regulates endothelial cell development relationship: RO:0002212 GO:0001885 ! negatively regulates endothelial cell development creation_date: 2012-10-30T12:59:54Z [Term] id: GO:1901552 name: positive regulation of endothelial cell development namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of endothelial cell development." [GOC:pr, GOC:TermGenie, PMID:19470579] synonym: "activation of endothelial cell development" NARROW [GOC:TermGenie] synonym: "up regulation of endothelial cell development" EXACT [GOC:TermGenie] synonym: "up-regulation of endothelial cell development" EXACT [GOC:TermGenie] synonym: "upregulation of endothelial cell development" EXACT [GOC:TermGenie] is_a: GO:0010720 ! positive regulation of cell development is_a: GO:1901550 ! regulation of endothelial cell development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0001885 ! positively regulates endothelial cell development relationship: RO:0002213 GO:0001885 ! positively regulates endothelial cell development creation_date: 2012-10-30T12:59:58Z [Term] id: GO:1901588 name: dendritic microtubule namespace: cellular_component def: "Any microtubule in a dendrite, a neuron projection." [GOC:TermGenie, NIF_Subcellular:sao110773650] synonym: "microtubule of dendrite" EXACT [GOC:TermGenie] synonym: "microtubulus of dendrite" EXACT [GOC:TermGenie] xref: NIF_Subcellular:sao110773650 is_a: GO:0005874 ! microtubule intersection_of: GO:0005874 ! microtubule intersection_of: BFO:0000050 GO:0030425 ! part of dendrite relationship: BFO:0000050 GO:0030425 ! part of dendrite creation_date: 2012-11-07T14:37:30Z [Term] id: GO:1901589 name: axon microtubule bundle namespace: cellular_component def: "An arrangement of closely apposed microtubules running parallel to each other in the axon hillock and initial segment." [GOC:TermGenie, NIF_Subcellular:sao707332678] synonym: "axon microtubule fascicle" EXACT [] synonym: "microtubule bundle of axon" EXACT [GOC:TermGenie] synonym: "microtubule fascicle of axon" EXACT [GOC:TermGenie] xref: NIF_Subcellular:sao707332678 is_a: GO:0097427 ! microtubule bundle intersection_of: GO:0097427 ! microtubule bundle intersection_of: BFO:0000050 GO:0030424 ! part of axon relationship: BFO:0000050 GO:0030424 ! part of axon creation_date: 2012-11-07T15:37:12Z [Term] id: GO:1901605 name: alpha-amino acid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving an alpha-amino acid." [GOC:TermGenie] synonym: "alpha-amino acid metabolism" EXACT [GOC:TermGenie] is_a: GO:0006520 ! amino acid metabolic process is_a: GO:0019752 ! carboxylic acid metabolic process intersection_of: GO:0008152 ! metabolic process intersection_of: RO:0004007 CHEBI:78608 ! has primary input or output relationship: RO:0004007 CHEBI:78608 ! has primary input or output creation_date: 2012-11-08T17:39:50Z [Term] id: GO:1901606 name: alpha-amino acid catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of an alpha-amino acid." [GOC:TermGenie] synonym: "alpha-amino acid breakdown" EXACT [GOC:TermGenie] synonym: "alpha-amino acid catabolism" EXACT [GOC:TermGenie] synonym: "alpha-amino acid degradation" EXACT [GOC:TermGenie] is_a: GO:0009063 ! amino acid catabolic process is_a: GO:0046395 ! carboxylic acid catabolic process is_a: GO:1901605 ! alpha-amino acid metabolic process intersection_of: GO:0009056 ! catabolic process intersection_of: RO:0004009 CHEBI:78608 ! has primary input relationship: RO:0004009 CHEBI:78608 ! has primary input creation_date: 2012-11-08T17:39:54Z [Term] id: GO:1901607 name: alpha-amino acid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of an alpha-amino acid." [GOC:TermGenie] synonym: "alpha-amino acid anabolism" EXACT [GOC:TermGenie] synonym: "alpha-amino acid biosynthesis" EXACT [GOC:TermGenie] synonym: "alpha-amino acid formation" EXACT [GOC:TermGenie] synonym: "alpha-amino acid synthesis" EXACT [GOC:TermGenie] is_a: GO:0008652 ! amino acid biosynthetic process is_a: GO:0046394 ! carboxylic acid biosynthetic process is_a: GO:1901605 ! alpha-amino acid metabolic process intersection_of: GO:0009058 ! biosynthetic process intersection_of: RO:0004008 CHEBI:78608 ! has primary output relationship: RO:0004008 CHEBI:78608 ! has primary output creation_date: 2012-11-08T17:39:58Z [Term] id: GO:1901608 name: regulation of vesicle transport along microtubule namespace: biological_process def: "Any process that modulates the frequency, rate or extent of vesicle transport along microtubule." [GOC:TermGenie] synonym: "regulation of microtubule-based vesicle localization" EXACT [GOC:TermGenie] is_a: GO:1902513 ! regulation of organelle transport along microtubule intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0047496 ! regulates vesicle transport along microtubule relationship: RO:0002211 GO:0047496 ! regulates vesicle transport along microtubule creation_date: 2012-11-08T21:49:44Z [Term] id: GO:1901609 name: negative regulation of vesicle transport along microtubule namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of vesicle transport along microtubule." [GOC:TermGenie] synonym: "down regulation of microtubule-based vesicle localization" EXACT [GOC:TermGenie] synonym: "down regulation of vesicle transport along microtubule" EXACT [GOC:TermGenie] synonym: "down-regulation of microtubule-based vesicle localization" EXACT [GOC:TermGenie] synonym: "down-regulation of vesicle transport along microtubule" EXACT [GOC:TermGenie] synonym: "downregulation of microtubule-based vesicle localization" EXACT [GOC:TermGenie] synonym: "downregulation of vesicle transport along microtubule" EXACT [GOC:TermGenie] synonym: "inhibition of microtubule-based vesicle localization" EXACT [GOC:TermGenie] synonym: "inhibition of vesicle transport along microtubule" NARROW [GOC:TermGenie] synonym: "negative regulation of microtubule-based vesicle localization" EXACT [GOC:TermGenie] is_a: GO:0032387 ! negative regulation of intracellular transport is_a: GO:1901608 ! regulation of vesicle transport along microtubule intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0047496 ! negatively regulates vesicle transport along microtubule relationship: RO:0002212 GO:0047496 ! negatively regulates vesicle transport along microtubule creation_date: 2012-11-08T21:49:48Z [Term] id: GO:1901610 name: positive regulation of vesicle transport along microtubule namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of vesicle transport along microtubule." [GOC:TermGenie] synonym: "activation of microtubule-based vesicle localization" EXACT [GOC:TermGenie] synonym: "activation of vesicle transport along microtubule" NARROW [GOC:TermGenie] synonym: "positive regulation of microtubule-based vesicle localization" EXACT [GOC:TermGenie] synonym: "up regulation of microtubule-based vesicle localization" EXACT [GOC:TermGenie] synonym: "up regulation of vesicle transport along microtubule" EXACT [GOC:TermGenie] synonym: "up-regulation of microtubule-based vesicle localization" EXACT [GOC:TermGenie] synonym: "up-regulation of vesicle transport along microtubule" EXACT [GOC:TermGenie] synonym: "upregulation of microtubule-based vesicle localization" EXACT [GOC:TermGenie] synonym: "upregulation of vesicle transport along microtubule" EXACT [GOC:TermGenie] is_a: GO:0032388 ! positive regulation of intracellular transport is_a: GO:1901608 ! regulation of vesicle transport along microtubule intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0047496 ! positively regulates vesicle transport along microtubule relationship: RO:0002213 GO:0047496 ! positively regulates vesicle transport along microtubule creation_date: 2012-11-08T21:49:53Z [Term] id: GO:1901613 name: negative regulation of terminal button organization namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of terminal button organization." [GOC:TermGenie, PMID:22426000] synonym: "down regulation of bouton organization" EXACT [GOC:TermGenie] synonym: "down regulation of presynaptic bouton organization" EXACT [GOC:TermGenie] synonym: "down regulation of synaptic bouton organization" EXACT [GOC:TermGenie] synonym: "down regulation of terminal bouton organization" EXACT [GOC:TermGenie] synonym: "down regulation of terminal button organisation" EXACT [GOC:TermGenie] synonym: "down regulation of terminal button organization" EXACT [GOC:TermGenie] synonym: "down-regulation of bouton organization" EXACT [GOC:TermGenie] synonym: "down-regulation of presynaptic bouton organization" EXACT [GOC:TermGenie] synonym: "down-regulation of synaptic bouton organization" EXACT [GOC:TermGenie] synonym: "down-regulation of terminal bouton organization" EXACT [GOC:TermGenie] synonym: "down-regulation of terminal button organisation" EXACT [GOC:TermGenie] synonym: "down-regulation of terminal button organization" EXACT [GOC:TermGenie] synonym: "downregulation of bouton organization" EXACT [GOC:TermGenie] synonym: "downregulation of presynaptic bouton organization" EXACT [GOC:TermGenie] synonym: "downregulation of synaptic bouton organization" EXACT [GOC:TermGenie] synonym: "downregulation of terminal bouton organization" EXACT [GOC:TermGenie] synonym: "downregulation of terminal button organisation" EXACT [GOC:TermGenie] synonym: "downregulation of terminal button organization" EXACT [GOC:TermGenie] synonym: "inhibition of bouton organization" NARROW [GOC:TermGenie] synonym: "inhibition of presynaptic bouton organization" NARROW [GOC:TermGenie] synonym: "inhibition of synaptic bouton organization" NARROW [GOC:TermGenie] synonym: "inhibition of terminal bouton organization" NARROW [GOC:TermGenie] synonym: "inhibition of terminal button organisation" NARROW [GOC:TermGenie] synonym: "inhibition of terminal button organization" NARROW [GOC:TermGenie] synonym: "negative regulation of bouton organization" EXACT [GOC:TermGenie] synonym: "negative regulation of presynaptic bouton organization" EXACT [GOC:TermGenie] synonym: "negative regulation of synaptic bouton organization" EXACT [GOC:TermGenie] synonym: "negative regulation of terminal bouton organization" EXACT [GOC:TermGenie] synonym: "negative regulation of terminal button organisation" EXACT [GOC:TermGenie] is_a: GO:0051129 ! negative regulation of cellular component organization is_a: GO:2000331 ! regulation of terminal button organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0072553 ! negatively regulates terminal button organization relationship: RO:0002212 GO:0072553 ! negatively regulates terminal button organization creation_date: 2012-11-13T10:40:51Z [Term] id: GO:1901614 name: positive regulation of terminal button organization namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of terminal button organization." [GOC:TermGenie, PMID:22426000] synonym: "activation of bouton organization" NARROW [GOC:TermGenie] synonym: "activation of presynaptic bouton organization" NARROW [GOC:TermGenie] synonym: "activation of synaptic bouton organization" NARROW [GOC:TermGenie] synonym: "activation of terminal bouton organization" NARROW [GOC:TermGenie] synonym: "activation of terminal button organisation" NARROW [GOC:TermGenie] synonym: "activation of terminal button organization" NARROW [GOC:TermGenie] synonym: "positive regulation of bouton organization" EXACT [GOC:TermGenie] synonym: "positive regulation of presynaptic bouton organization" EXACT [GOC:TermGenie] synonym: "positive regulation of synaptic bouton organization" EXACT [GOC:TermGenie] synonym: "positive regulation of terminal bouton organization" EXACT [GOC:TermGenie] synonym: "positive regulation of terminal button organisation" EXACT [GOC:TermGenie] synonym: "up regulation of bouton organization" EXACT [GOC:TermGenie] synonym: "up regulation of presynaptic bouton organization" EXACT [GOC:TermGenie] synonym: "up regulation of synaptic bouton organization" EXACT [GOC:TermGenie] synonym: "up regulation of terminal bouton organization" EXACT [GOC:TermGenie] synonym: "up regulation of terminal button organisation" EXACT [GOC:TermGenie] synonym: "up regulation of terminal button organization" EXACT [GOC:TermGenie] synonym: "up-regulation of bouton organization" EXACT [GOC:TermGenie] synonym: "up-regulation of presynaptic bouton organization" EXACT [GOC:TermGenie] synonym: "up-regulation of synaptic bouton organization" EXACT [GOC:TermGenie] synonym: "up-regulation of terminal bouton organization" EXACT [GOC:TermGenie] synonym: "up-regulation of terminal button organisation" EXACT [GOC:TermGenie] synonym: "up-regulation of terminal button organization" EXACT [GOC:TermGenie] synonym: "upregulation of bouton organization" EXACT [GOC:TermGenie] synonym: "upregulation of presynaptic bouton organization" EXACT [GOC:TermGenie] synonym: "upregulation of synaptic bouton organization" EXACT [GOC:TermGenie] synonym: "upregulation of terminal bouton organization" EXACT [GOC:TermGenie] synonym: "upregulation of terminal button organisation" EXACT [GOC:TermGenie] synonym: "upregulation of terminal button organization" EXACT [GOC:TermGenie] is_a: GO:0051130 ! positive regulation of cellular component organization is_a: GO:2000331 ! regulation of terminal button organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0072553 ! positively regulates terminal button organization relationship: RO:0002213 GO:0072553 ! positively regulates terminal button organization creation_date: 2012-11-13T10:40:58Z [Term] id: GO:1901623 name: regulation of lymphocyte chemotaxis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of lymphocyte chemotaxis." [GOC:TermGenie] is_a: GO:0002688 ! regulation of leukocyte chemotaxis is_a: GO:2000401 ! regulation of lymphocyte migration intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0048247 ! regulates lymphocyte chemotaxis relationship: RO:0002211 GO:0048247 ! regulates lymphocyte chemotaxis creation_date: 2012-11-13T23:03:23Z [Term] id: GO:1901624 name: negative regulation of lymphocyte chemotaxis namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of lymphocyte chemotaxis." [GOC:TermGenie] synonym: "down regulation of lymphocyte chemotaxis" EXACT [GOC:TermGenie] synonym: "down-regulation of lymphocyte chemotaxis" EXACT [GOC:TermGenie] synonym: "downregulation of lymphocyte chemotaxis" EXACT [GOC:TermGenie] synonym: "inhibition of lymphocyte chemotaxis" NARROW [GOC:TermGenie] is_a: GO:0002689 ! negative regulation of leukocyte chemotaxis is_a: GO:1901623 ! regulation of lymphocyte chemotaxis is_a: GO:2000402 ! negative regulation of lymphocyte migration intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0048247 ! negatively regulates lymphocyte chemotaxis relationship: RO:0002212 GO:0048247 ! negatively regulates lymphocyte chemotaxis creation_date: 2012-11-13T23:03:28Z [Term] id: GO:1901626 name: regulation of postsynaptic membrane organization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of postsynaptic membrane organization." [GOC:TermGenie, PMID:22426000] synonym: "regulation of post-synaptic membrane organization" EXACT [] synonym: "regulation of postsynaptic membrane organisation" EXACT [GOC:TermGenie] is_a: GO:0051128 ! regulation of cellular component organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0001941 ! regulates postsynaptic membrane organization relationship: RO:0002211 GO:0001941 ! regulates postsynaptic membrane organization creation_date: 2012-11-15T11:40:15Z [Term] id: GO:1901627 name: negative regulation of postsynaptic membrane organization namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of postsynaptic membrane organization." [GOC:TermGenie, PMID:22426000] synonym: "down regulation of postsynaptic membrane organisation" EXACT [GOC:TermGenie] synonym: "down regulation of postsynaptic membrane organization" EXACT [GOC:TermGenie] synonym: "down-regulation of postsynaptic membrane organisation" EXACT [GOC:TermGenie] synonym: "down-regulation of postsynaptic membrane organization" EXACT [GOC:TermGenie] synonym: "downregulation of postsynaptic membrane organisation" EXACT [GOC:TermGenie] synonym: "downregulation of postsynaptic membrane organization" EXACT [GOC:TermGenie] synonym: "inhibition of postsynaptic membrane organisation" NARROW [GOC:TermGenie] synonym: "inhibition of postsynaptic membrane organization" NARROW [GOC:TermGenie] synonym: "negative regulation of post-synaptic membrane organization" EXACT [] synonym: "negative regulation of postsynaptic membrane organisation" EXACT [GOC:TermGenie] is_a: GO:1901626 ! regulation of postsynaptic membrane organization is_a: GO:1905809 ! negative regulation of synapse organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0001941 ! negatively regulates postsynaptic membrane organization relationship: RO:0002212 GO:0001941 ! negatively regulates postsynaptic membrane organization creation_date: 2012-11-15T11:40:20Z [Term] id: GO:1901628 name: positive regulation of postsynaptic membrane organization namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of postsynaptic membrane organization." [GOC:TermGenie, PMID:22426000] synonym: "activation of postsynaptic membrane organisation" NARROW [GOC:TermGenie] synonym: "activation of postsynaptic membrane organization" NARROW [GOC:TermGenie] synonym: "positive regulation of post-synaptic membrane organization" EXACT [] synonym: "positive regulation of postsynaptic membrane organisation" EXACT [GOC:TermGenie] synonym: "up regulation of postsynaptic membrane organisation" EXACT [GOC:TermGenie] synonym: "up regulation of postsynaptic membrane organization" EXACT [GOC:TermGenie] synonym: "up-regulation of postsynaptic membrane organisation" EXACT [GOC:TermGenie] synonym: "up-regulation of postsynaptic membrane organization" EXACT [GOC:TermGenie] synonym: "upregulation of postsynaptic membrane organisation" EXACT [GOC:TermGenie] synonym: "upregulation of postsynaptic membrane organization" EXACT [GOC:TermGenie] is_a: GO:0051130 ! positive regulation of cellular component organization is_a: GO:1901626 ! regulation of postsynaptic membrane organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0001941 ! positively regulates postsynaptic membrane organization relationship: RO:0002213 GO:0001941 ! positively regulates postsynaptic membrane organization creation_date: 2012-11-15T11:40:24Z [Term] id: GO:1901645 name: regulation of synoviocyte proliferation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of synoviocyte proliferation." [GOC:TermGenie] is_a: GO:0050678 ! regulation of epithelial cell proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0002941 ! regulates synoviocyte proliferation relationship: RO:0002211 GO:0002941 ! regulates synoviocyte proliferation property_value: RO:0002161 NCBITaxon:4751 creation_date: 2012-11-16T20:16:23Z [Term] id: GO:1901646 name: negative regulation of synoviocyte proliferation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of synoviocyte proliferation." [GOC:TermGenie] synonym: "down regulation of synoviocyte proliferation" EXACT [GOC:TermGenie] synonym: "down-regulation of synoviocyte proliferation" EXACT [GOC:TermGenie] synonym: "downregulation of synoviocyte proliferation" EXACT [GOC:TermGenie] synonym: "inhibition of synoviocyte proliferation" NARROW [GOC:TermGenie] is_a: GO:0050680 ! negative regulation of epithelial cell proliferation is_a: GO:1901645 ! regulation of synoviocyte proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0002941 ! negatively regulates synoviocyte proliferation relationship: RO:0002212 GO:0002941 ! negatively regulates synoviocyte proliferation property_value: RO:0002161 NCBITaxon:4751 creation_date: 2012-11-16T20:16:27Z [Term] id: GO:1901647 name: positive regulation of synoviocyte proliferation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of synoviocyte proliferation." [GOC:TermGenie] synonym: "activation of synoviocyte proliferation" NARROW [GOC:TermGenie] synonym: "up regulation of synoviocyte proliferation" EXACT [GOC:TermGenie] synonym: "up-regulation of synoviocyte proliferation" EXACT [GOC:TermGenie] synonym: "upregulation of synoviocyte proliferation" EXACT [GOC:TermGenie] is_a: GO:0050679 ! positive regulation of epithelial cell proliferation is_a: GO:1901645 ! regulation of synoviocyte proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0002941 ! positively regulates synoviocyte proliferation relationship: RO:0002213 GO:0002941 ! positively regulates synoviocyte proliferation property_value: RO:0002161 NCBITaxon:4751 creation_date: 2012-11-16T20:16:32Z [Term] id: GO:1901652 name: response to peptide namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptide stimulus." [GOC:pr, GOC:TermGenie] is_a: GO:0042221 ! response to chemical intersection_of: GO:0050896 ! response to stimulus intersection_of: RO:0004009 CHEBI:60466 ! has primary input relationship: RO:0004009 CHEBI:60466 ! has primary input creation_date: 2012-11-20T09:45:15Z [Term] id: GO:1901653 name: cellular response to peptide namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptide stimulus." [GOC:pr, GOC:TermGenie] is_a: GO:0070887 ! cellular response to chemical stimulus is_a: GO:1901652 ! response to peptide intersection_of: GO:0070887 ! cellular response to chemical stimulus intersection_of: RO:0004009 CHEBI:60466 ! has primary input creation_date: 2012-11-20T09:45:19Z [Term] id: GO:1901654 name: response to ketone namespace: biological_process def: "A response that results in a state of tolerance to ketone." [GOC:mengo_curators, PMID:23356676] synonym: "process resulting in tolerance to ketone" NARROW [] is_a: GO:1901700 ! response to oxygen-containing compound intersection_of: GO:0050896 ! response to stimulus intersection_of: RO:0004009 CHEBI:17087 ! has primary input relationship: RO:0004009 CHEBI:17087 ! has primary input creation_date: 2012-11-20T10:55:47Z [Term] id: GO:1901655 name: cellular response to ketone namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ketone stimulus." [GOC:pr, GOC:TermGenie] is_a: GO:1901654 ! response to ketone is_a: GO:1901701 ! cellular response to oxygen-containing compound intersection_of: GO:0070887 ! cellular response to chemical stimulus intersection_of: RO:0004009 CHEBI:17087 ! has primary input creation_date: 2012-11-20T10:55:51Z [Term] id: GO:1901667 name: negative regulation of skeletal muscle satellite cell activation involved in skeletal muscle regeneration namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of satellite cell activation involved in skeletal muscle regeneration." [GOC:dph, GOC:TermGenie, PMID:21272575] synonym: "down regulation of satellite cell activation involved in skeletal muscle regeneration" EXACT [GOC:TermGenie] synonym: "down-regulation of satellite cell activation involved in skeletal muscle regeneration" EXACT [GOC:TermGenie] synonym: "downregulation of satellite cell activation involved in skeletal muscle regeneration" EXACT [GOC:TermGenie] synonym: "inhibition of satellite cell activation involved in skeletal muscle regeneration" NARROW [GOC:TermGenie] is_a: GO:0014717 ! regulation of satellite cell activation involved in skeletal muscle regeneration is_a: GO:0043417 ! negative regulation of skeletal muscle tissue regeneration is_a: GO:0050866 ! negative regulation of cell activation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0014901 ! negatively regulates satellite cell activation involved in skeletal muscle regeneration relationship: RO:0002212 GO:0014901 ! negatively regulates satellite cell activation involved in skeletal muscle regeneration creation_date: 2012-11-21T16:21:11Z [Term] id: GO:1901679 name: nucleotide transmembrane transport namespace: biological_process def: "The directed movement of nucleotide across a membrane." [GOC:pr, GOC:TermGenie] comment: Note that this term is not intended for use in annotating lateral movement within membranes. synonym: "nucleotide membrane transport" EXACT [] is_a: GO:0006862 ! nucleotide transport is_a: GO:0055085 ! transmembrane transport intersection_of: GO:0055085 ! transmembrane transport intersection_of: RO:0004009 CHEBI:36976 ! has primary input creation_date: 2012-11-22T15:43:23Z [Term] id: GO:1901681 name: sulfur compound binding namespace: molecular_function def: "Binding to a sulfur compound." [GOC:pr, GOC:TermGenie] synonym: "sulfur molecular entity binding" EXACT [] is_a: BFO:0000003 is_a: GO:0005488 ! binding intersection_of: GO:0005488 ! binding intersection_of: RO:0004009 CHEBI:26835 ! has primary input relationship: RO:0004009 CHEBI:26835 ! has primary input creation_date: 2012-11-26T20:45:23Z [Term] id: GO:1901682 name: sulfur compound transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of a sulfur compound from one side of a membrane to the other." [GOC:pr, GOC:TermGenie] synonym: "sulfur molecular entity transmembrane transporter activity" EXACT [] is_a: GO:0022857 ! transmembrane transporter activity intersection_of: GO:0022857 ! transmembrane transporter activity intersection_of: RO:0004009 CHEBI:26835 ! has primary input relationship: RO:0004009 CHEBI:26835 ! has primary input creation_date: 2012-11-26T20:45:29Z [Term] id: GO:1901691 name: proton binding namespace: molecular_function def: "Binding to proton." [GOC:TermGenie] synonym: "hydrogen ion binding" EXACT [GOC:bm] is_a: GO:0043169 ! cation binding intersection_of: GO:0005488 ! binding intersection_of: RO:0004009 CHEBI:15378 ! has primary input relationship: RO:0004009 CHEBI:15378 ! has primary input creation_date: 2012-12-07T13:50:53Z [Term] id: GO:1901692 name: regulation of compound eye retinal cell apoptotic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of compound eye retinal cell apoptotic process." [GOC:mtg_apoptosis, GOC:TermGenie, PMID:12021768] is_a: GO:0042981 ! regulation of apoptotic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:1990010 ! regulates compound eye retinal cell apoptotic process relationship: RO:0002211 GO:1990010 ! regulates compound eye retinal cell apoptotic process property_value: RO:0002161 NCBITaxon:4896 creation_date: 2012-12-12T10:28:35Z [Term] id: GO:1901693 name: negative regulation of compound eye retinal cell apoptotic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of compound eye retinal cell apoptotic process." [GOC:mtg_apoptosis, GOC:TermGenie, PMID:12021768] synonym: "down regulation of compound eye retinal cell apoptotic process" EXACT [GOC:TermGenie] synonym: "down-regulation of compound eye retinal cell apoptotic process" EXACT [GOC:TermGenie] synonym: "downregulation of compound eye retinal cell apoptotic process" EXACT [GOC:TermGenie] synonym: "inhibition of compound eye retinal cell apoptotic process" NARROW [GOC:TermGenie] is_a: GO:0043066 ! negative regulation of apoptotic process is_a: GO:1901692 ! regulation of compound eye retinal cell apoptotic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:1990010 ! negatively regulates compound eye retinal cell apoptotic process relationship: RO:0002212 GO:1990010 ! negatively regulates compound eye retinal cell apoptotic process property_value: RO:0002161 NCBITaxon:4896 creation_date: 2012-12-12T10:28:40Z [Term] id: GO:1901694 name: positive regulation of compound eye retinal cell apoptotic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of compound eye retinal cell apoptotic process." [GOC:mtg_apoptosis, GOC:TermGenie, PMID:12021768] synonym: "activation of compound eye retinal cell apoptotic process" NARROW [GOC:TermGenie] synonym: "induction of compound eye retinal cell programmed cell death" RELATED [] synonym: "up regulation of compound eye retinal cell apoptotic process" EXACT [GOC:TermGenie] synonym: "up-regulation of compound eye retinal cell apoptotic process" EXACT [GOC:TermGenie] synonym: "upregulation of compound eye retinal cell apoptotic process" EXACT [GOC:TermGenie] is_a: GO:0043065 ! positive regulation of apoptotic process is_a: GO:0046672 ! positive regulation of compound eye retinal cell programmed cell death is_a: GO:1901692 ! regulation of compound eye retinal cell apoptotic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:1990010 ! positively regulates compound eye retinal cell apoptotic process relationship: RO:0002213 GO:1990010 ! positively regulates compound eye retinal cell apoptotic process creation_date: 2012-12-12T10:28:45Z [Term] id: GO:1901698 name: response to nitrogen compound namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitrogen compound stimulus." [GOC:pr, GOC:TermGenie] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_annotate synonym: "response to nitrogen molecular entity" EXACT [] is_a: GO:0042221 ! response to chemical intersection_of: GO:0050896 ! response to stimulus intersection_of: RO:0004009 CHEBI:51143 ! has primary input relationship: RO:0004009 CHEBI:51143 ! has primary input property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/27194" xsd:anyURI creation_date: 2012-12-13T15:06:08Z [Term] id: GO:1901699 name: cellular response to nitrogen compound namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitrogen compound stimulus." [GOC:pr, GOC:TermGenie] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_annotate synonym: "cellular response to nitrogen molecular entity" EXACT [] is_a: GO:0070887 ! cellular response to chemical stimulus is_a: GO:1901698 ! response to nitrogen compound intersection_of: GO:0070887 ! cellular response to chemical stimulus intersection_of: RO:0004009 CHEBI:51143 ! has primary input property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/27194" xsd:anyURI creation_date: 2012-12-13T15:06:13Z [Term] id: GO:1901700 name: response to oxygen-containing compound namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an oxygen-containing compound stimulus." [GOC:pr, GOC:TermGenie] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_annotate synonym: "response to oxygen molecular entity" EXACT [] is_a: GO:0042221 ! response to chemical intersection_of: GO:0050896 ! response to stimulus intersection_of: RO:0004009 CHEBI:25806 ! has primary input relationship: RO:0004009 CHEBI:25806 ! has primary input property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/27194" xsd:anyURI creation_date: 2012-12-13T15:11:37Z [Term] id: GO:1901701 name: cellular response to oxygen-containing compound namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an oxygen-containing compound stimulus." [GOC:pr, GOC:TermGenie] synonym: "cellular response to oxygen molecular entity" EXACT [] is_a: GO:0070887 ! cellular response to chemical stimulus is_a: GO:1901700 ! response to oxygen-containing compound intersection_of: GO:0070887 ! cellular response to chemical stimulus intersection_of: RO:0004009 CHEBI:25806 ! has primary input creation_date: 2012-12-13T15:11:42Z [Term] id: GO:1901706 name: mesenchymal cell differentiation involved in bone development namespace: biological_process def: "The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the mesenchymal cells of bone as it progresses from its formation to the mature state." [GOC:hjd, GOC:TermGenie, PMID:21571217] is_a: GO:0048762 ! mesenchymal cell differentiation intersection_of: GO:0048762 ! mesenchymal cell differentiation intersection_of: BFO:0000050 GO:0060348 ! part of bone development relationship: BFO:0000050 GO:0060348 ! part of bone development creation_date: 2012-12-14T16:04:16Z [Term] id: GO:1901715 name: regulation of gamma-aminobutyric acid catabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of gamma-aminobutyric acid catabolic process." [GOC:TermGenie] synonym: "regulation of 4-aminobutanoate catabolic process" EXACT [GOC:TermGenie] synonym: "regulation of 4-aminobutanoate catabolism" EXACT [GOC:TermGenie] synonym: "regulation of 4-aminobutyrate catabolic process" EXACT [GOC:TermGenie] synonym: "regulation of 4-aminobutyrate catabolism" EXACT [GOC:TermGenie] synonym: "regulation of GABA catabolic process" EXACT [GOC:TermGenie] synonym: "regulation of GABA catabolism" EXACT [GOC:TermGenie] synonym: "regulation of gamma-aminobutyric acid breakdown" EXACT [GOC:TermGenie] synonym: "regulation of gamma-aminobutyric acid catabolism" EXACT [GOC:TermGenie] synonym: "regulation of gamma-aminobutyric acid degradation" EXACT [GOC:TermGenie] is_a: GO:0006521 ! regulation of amino acid metabolic process is_a: GO:0009894 ! regulation of catabolic process is_a: GO:0062012 ! regulation of small molecule metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0009450 ! regulates gamma-aminobutyric acid catabolic process relationship: RO:0002211 GO:0009450 ! regulates gamma-aminobutyric acid catabolic process creation_date: 2012-12-19T16:13:24Z [Term] id: GO:1901716 name: negative regulation of gamma-aminobutyric acid catabolic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of gamma-aminobutyric acid catabolic process." [GOC:TermGenie] synonym: "down regulation of 4-aminobutanoate catabolic process" EXACT [GOC:TermGenie] synonym: "down regulation of 4-aminobutanoate catabolism" EXACT [GOC:TermGenie] synonym: "down regulation of 4-aminobutyrate catabolic process" EXACT [GOC:TermGenie] synonym: "down regulation of 4-aminobutyrate catabolism" EXACT [GOC:TermGenie] synonym: "down regulation of GABA catabolic process" EXACT [GOC:TermGenie] synonym: "down regulation of GABA catabolism" EXACT [GOC:TermGenie] synonym: "down regulation of gamma-aminobutyric acid breakdown" EXACT [GOC:TermGenie] synonym: "down regulation of gamma-aminobutyric acid catabolic process" EXACT [GOC:TermGenie] synonym: "down regulation of gamma-aminobutyric acid catabolism" EXACT [GOC:TermGenie] synonym: "down regulation of gamma-aminobutyric acid degradation" EXACT [GOC:TermGenie] synonym: "down-regulation of 4-aminobutanoate catabolic process" EXACT [GOC:TermGenie] synonym: "down-regulation of 4-aminobutanoate catabolism" EXACT [GOC:TermGenie] synonym: "down-regulation of 4-aminobutyrate catabolic process" EXACT [GOC:TermGenie] synonym: "down-regulation of 4-aminobutyrate catabolism" EXACT [GOC:TermGenie] synonym: "down-regulation of GABA catabolic process" EXACT [GOC:TermGenie] synonym: "down-regulation of GABA catabolism" EXACT [GOC:TermGenie] synonym: "down-regulation of gamma-aminobutyric acid breakdown" EXACT [GOC:TermGenie] synonym: "down-regulation of gamma-aminobutyric acid catabolic process" EXACT [GOC:TermGenie] synonym: "down-regulation of gamma-aminobutyric acid catabolism" EXACT [GOC:TermGenie] synonym: "down-regulation of gamma-aminobutyric acid degradation" EXACT [GOC:TermGenie] synonym: "downregulation of 4-aminobutanoate catabolic process" EXACT [GOC:TermGenie] synonym: "downregulation of 4-aminobutanoate catabolism" EXACT [GOC:TermGenie] synonym: "downregulation of 4-aminobutyrate catabolic process" EXACT [GOC:TermGenie] synonym: "downregulation of 4-aminobutyrate catabolism" EXACT [GOC:TermGenie] synonym: "downregulation of GABA catabolic process" EXACT [GOC:TermGenie] synonym: "downregulation of GABA catabolism" EXACT [GOC:TermGenie] synonym: "downregulation of gamma-aminobutyric acid breakdown" EXACT [GOC:TermGenie] synonym: "downregulation of gamma-aminobutyric acid catabolic process" EXACT [GOC:TermGenie] synonym: "downregulation of gamma-aminobutyric acid catabolism" EXACT [GOC:TermGenie] synonym: "downregulation of gamma-aminobutyric acid degradation" EXACT [GOC:TermGenie] synonym: "inhibition of 4-aminobutanoate catabolic process" EXACT [GOC:TermGenie] synonym: "inhibition of 4-aminobutanoate catabolism" EXACT [GOC:TermGenie] synonym: "inhibition of 4-aminobutyrate catabolic process" EXACT [GOC:TermGenie] synonym: "inhibition of 4-aminobutyrate catabolism" EXACT [GOC:TermGenie] synonym: "inhibition of GABA catabolic process" EXACT [GOC:TermGenie] synonym: "inhibition of GABA catabolism" EXACT [GOC:TermGenie] synonym: "inhibition of gamma-aminobutyric acid breakdown" EXACT [GOC:TermGenie] synonym: "inhibition of gamma-aminobutyric acid catabolic process" NARROW [GOC:TermGenie] synonym: "inhibition of gamma-aminobutyric acid catabolism" EXACT [GOC:TermGenie] synonym: "inhibition of gamma-aminobutyric acid degradation" EXACT [GOC:TermGenie] synonym: "negative regulation of 4-aminobutanoate catabolic process" EXACT [GOC:TermGenie] synonym: "negative regulation of 4-aminobutanoate catabolism" EXACT [GOC:TermGenie] synonym: "negative regulation of 4-aminobutyrate catabolic process" EXACT [GOC:TermGenie] synonym: "negative regulation of 4-aminobutyrate catabolism" EXACT [GOC:TermGenie] synonym: "negative regulation of GABA catabolic process" EXACT [GOC:TermGenie] synonym: "negative regulation of GABA catabolism" EXACT [GOC:TermGenie] synonym: "negative regulation of gamma-aminobutyric acid breakdown" EXACT [GOC:TermGenie] synonym: "negative regulation of gamma-aminobutyric acid catabolism" EXACT [GOC:TermGenie] synonym: "negative regulation of gamma-aminobutyric acid degradation" EXACT [GOC:TermGenie] is_a: GO:0009895 ! negative regulation of catabolic process is_a: GO:0045763 ! negative regulation of amino acid metabolic process is_a: GO:0062014 ! negative regulation of small molecule metabolic process is_a: GO:1901715 ! regulation of gamma-aminobutyric acid catabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0009450 ! negatively regulates gamma-aminobutyric acid catabolic process relationship: RO:0002212 GO:0009450 ! negatively regulates gamma-aminobutyric acid catabolic process creation_date: 2012-12-19T16:13:31Z [Term] id: GO:1901717 name: positive regulation of gamma-aminobutyric acid catabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of gamma-aminobutyric acid catabolic process." [GOC:TermGenie] synonym: "activation of 4-aminobutanoate catabolic process" EXACT [GOC:TermGenie] synonym: "activation of 4-aminobutanoate catabolism" EXACT [GOC:TermGenie] synonym: "activation of 4-aminobutyrate catabolic process" EXACT [GOC:TermGenie] synonym: "activation of 4-aminobutyrate catabolism" EXACT [GOC:TermGenie] synonym: "activation of GABA catabolic process" EXACT [GOC:TermGenie] synonym: "activation of GABA catabolism" EXACT [GOC:TermGenie] synonym: "activation of gamma-aminobutyric acid breakdown" EXACT [GOC:TermGenie] synonym: "activation of gamma-aminobutyric acid catabolic process" NARROW [GOC:TermGenie] synonym: "activation of gamma-aminobutyric acid catabolism" EXACT [GOC:TermGenie] synonym: "activation of gamma-aminobutyric acid degradation" EXACT [GOC:TermGenie] synonym: "positive regulation of 4-aminobutanoate catabolic process" EXACT [GOC:TermGenie] synonym: "positive regulation of 4-aminobutanoate catabolism" EXACT [GOC:TermGenie] synonym: "positive regulation of 4-aminobutyrate catabolic process" EXACT [GOC:TermGenie] synonym: "positive regulation of 4-aminobutyrate catabolism" EXACT [GOC:TermGenie] synonym: "positive regulation of GABA catabolic process" EXACT [GOC:TermGenie] synonym: "positive regulation of GABA catabolism" EXACT [GOC:TermGenie] synonym: "positive regulation of gamma-aminobutyric acid breakdown" EXACT [GOC:TermGenie] synonym: "positive regulation of gamma-aminobutyric acid catabolism" EXACT [GOC:TermGenie] synonym: "positive regulation of gamma-aminobutyric acid degradation" EXACT [GOC:TermGenie] synonym: "up regulation of 4-aminobutanoate catabolic process" EXACT [GOC:TermGenie] synonym: "up regulation of 4-aminobutanoate catabolism" EXACT [GOC:TermGenie] synonym: "up regulation of 4-aminobutyrate catabolic process" EXACT [GOC:TermGenie] synonym: "up regulation of 4-aminobutyrate catabolism" EXACT [GOC:TermGenie] synonym: "up regulation of GABA catabolic process" EXACT [GOC:TermGenie] synonym: "up regulation of GABA catabolism" EXACT [GOC:TermGenie] synonym: "up regulation of gamma-aminobutyric acid breakdown" EXACT [GOC:TermGenie] synonym: "up regulation of gamma-aminobutyric acid catabolic process" EXACT [GOC:TermGenie] synonym: "up regulation of gamma-aminobutyric acid catabolism" EXACT [GOC:TermGenie] synonym: "up regulation of gamma-aminobutyric acid degradation" EXACT [GOC:TermGenie] synonym: "up-regulation of 4-aminobutanoate catabolic process" EXACT [GOC:TermGenie] synonym: "up-regulation of 4-aminobutanoate catabolism" EXACT [GOC:TermGenie] synonym: "up-regulation of 4-aminobutyrate catabolic process" EXACT [GOC:TermGenie] synonym: "up-regulation of 4-aminobutyrate catabolism" EXACT [GOC:TermGenie] synonym: "up-regulation of GABA catabolic process" EXACT [GOC:TermGenie] synonym: "up-regulation of GABA catabolism" EXACT [GOC:TermGenie] synonym: "up-regulation of gamma-aminobutyric acid breakdown" EXACT [GOC:TermGenie] synonym: "up-regulation of gamma-aminobutyric acid catabolic process" EXACT [GOC:TermGenie] synonym: "up-regulation of gamma-aminobutyric acid catabolism" EXACT [GOC:TermGenie] synonym: "up-regulation of gamma-aminobutyric acid degradation" EXACT [GOC:TermGenie] synonym: "upregulation of 4-aminobutanoate catabolic process" EXACT [GOC:TermGenie] synonym: "upregulation of 4-aminobutanoate catabolism" EXACT [GOC:TermGenie] synonym: "upregulation of 4-aminobutyrate catabolic process" EXACT [GOC:TermGenie] synonym: "upregulation of 4-aminobutyrate catabolism" EXACT [GOC:TermGenie] synonym: "upregulation of GABA catabolic process" EXACT [GOC:TermGenie] synonym: "upregulation of GABA catabolism" EXACT [GOC:TermGenie] synonym: "upregulation of gamma-aminobutyric acid breakdown" EXACT [GOC:TermGenie] synonym: "upregulation of gamma-aminobutyric acid catabolic process" EXACT [GOC:TermGenie] synonym: "upregulation of gamma-aminobutyric acid catabolism" EXACT [GOC:TermGenie] synonym: "upregulation of gamma-aminobutyric acid degradation" EXACT [GOC:TermGenie] is_a: GO:0009896 ! positive regulation of catabolic process is_a: GO:0045764 ! positive regulation of amino acid metabolic process is_a: GO:0062013 ! positive regulation of small molecule metabolic process is_a: GO:1901715 ! regulation of gamma-aminobutyric acid catabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0009450 ! positively regulates gamma-aminobutyric acid catabolic process relationship: RO:0002213 GO:0009450 ! positively regulates gamma-aminobutyric acid catabolic process creation_date: 2012-12-19T16:13:36Z [Term] id: GO:1901722 name: regulation of cell proliferation involved in kidney development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cell proliferation involved in kidney development." [GOC:TermGenie, PMID:18182616] is_a: GO:0042127 ! regulation of cell population proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0072111 ! regulates cell proliferation involved in kidney development relationship: RO:0002211 GO:0072111 ! regulates cell proliferation involved in kidney development creation_date: 2012-12-27T19:30:31Z [Term] id: GO:1901723 name: negative regulation of cell proliferation involved in kidney development namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of cell proliferation involved in kidney development." [GOC:TermGenie, PMID:18182616] synonym: "down regulation of cell proliferation involved in kidney development" EXACT [GOC:TermGenie] synonym: "down-regulation of cell proliferation involved in kidney development" EXACT [GOC:TermGenie] synonym: "downregulation of cell proliferation involved in kidney development" EXACT [GOC:TermGenie] synonym: "inhibition of cell proliferation involved in kidney development" NARROW [GOC:TermGenie] is_a: GO:0008285 ! negative regulation of cell population proliferation is_a: GO:1901722 ! regulation of cell proliferation involved in kidney development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0072111 ! negatively regulates cell proliferation involved in kidney development relationship: RO:0002212 GO:0072111 ! negatively regulates cell proliferation involved in kidney development creation_date: 2012-12-27T19:30:35Z [Term] id: GO:1901724 name: positive regulation of cell proliferation involved in kidney development namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cell proliferation involved in kidney development." [GOC:TermGenie, PMID:18182616] synonym: "activation of cell proliferation involved in kidney development" NARROW [GOC:TermGenie] synonym: "up regulation of cell proliferation involved in kidney development" EXACT [GOC:TermGenie] synonym: "up-regulation of cell proliferation involved in kidney development" EXACT [GOC:TermGenie] synonym: "upregulation of cell proliferation involved in kidney development" EXACT [GOC:TermGenie] is_a: GO:0008284 ! positive regulation of cell population proliferation is_a: GO:1901722 ! regulation of cell proliferation involved in kidney development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0072111 ! positively regulates cell proliferation involved in kidney development relationship: RO:0002213 GO:0072111 ! positively regulates cell proliferation involved in kidney development creation_date: 2012-12-27T19:30:40Z [Term] id: GO:1901826 name: zeaxanthin catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of zeaxanthin." [GOC:TermGenie, GOC:yaf, MetaCyc:PWY-5944, UniPathway:UPA00843] synonym: "zeaxanthin breakdown" EXACT [GOC:TermGenie] synonym: "zeaxanthin catabolism" EXACT [GOC:TermGenie] synonym: "zeaxanthin degradation" EXACT [GOC:TermGenie] is_a: GO:0016124 ! xanthophyll catabolic process intersection_of: GO:0009056 ! catabolic process intersection_of: RO:0004009 CHEBI:27547 ! has primary input relationship: RO:0004009 CHEBI:27547 ! has primary input property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 creation_date: 2013-01-22T11:37:00Z [Term] id: GO:1901827 name: zeaxanthin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of zeaxanthin." [GOC:TermGenie, GOC:yaf, MetaCyc:PWY-5944, UniPathway:UPA00843] synonym: "zeaxanthin anabolism" EXACT [GOC:TermGenie] synonym: "zeaxanthin biosynthesis" EXACT [GOC:TermGenie] synonym: "zeaxanthin formation" EXACT [GOC:TermGenie] synonym: "zeaxanthin synthesis" EXACT [GOC:TermGenie] xref: MetaCyc:PWY-5944 is_a: GO:0016123 ! xanthophyll biosynthetic process intersection_of: GO:0009058 ! biosynthetic process intersection_of: RO:0004008 CHEBI:27547 ! has primary output relationship: RO:0004008 CHEBI:27547 ! has primary output property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/28523" xsd:anyURI property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 creation_date: 2013-01-22T11:37:07Z [Term] id: GO:1901858 name: regulation of mitochondrial DNA metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of mitochondrial DNA metabolic process." [GOC:TermGenie, GOC:yaf, PMID:23150719] synonym: "regulation of mitochondrial DNA metabolism" EXACT [GOC:TermGenie] synonym: "regulation of mtDNA metabolic process" EXACT [GOC:TermGenie] synonym: "regulation of mtDNA metabolism" EXACT [GOC:TermGenie] is_a: GO:0051052 ! regulation of DNA metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0032042 ! regulates mitochondrial DNA metabolic process relationship: RO:0002211 GO:0032042 ! regulates mitochondrial DNA metabolic process creation_date: 2013-02-01T10:05:04Z [Term] id: GO:1901859 name: negative regulation of mitochondrial DNA metabolic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of mitochondrial DNA metabolic process." [GOC:TermGenie, GOC:yaf, PMID:23150719] synonym: "down regulation of mitochondrial DNA metabolic process" EXACT [GOC:TermGenie] synonym: "down regulation of mitochondrial DNA metabolism" EXACT [GOC:TermGenie] synonym: "down regulation of mtDNA metabolic process" EXACT [GOC:TermGenie] synonym: "down regulation of mtDNA metabolism" EXACT [GOC:TermGenie] synonym: "down-regulation of mitochondrial DNA metabolic process" EXACT [GOC:TermGenie] synonym: "down-regulation of mitochondrial DNA metabolism" EXACT [GOC:TermGenie] synonym: "down-regulation of mtDNA metabolic process" EXACT [GOC:TermGenie] synonym: "down-regulation of mtDNA metabolism" EXACT [GOC:TermGenie] synonym: "downregulation of mitochondrial DNA metabolic process" EXACT [GOC:TermGenie] synonym: "downregulation of mitochondrial DNA metabolism" EXACT [GOC:TermGenie] synonym: "downregulation of mtDNA metabolic process" EXACT [GOC:TermGenie] synonym: "downregulation of mtDNA metabolism" EXACT [GOC:TermGenie] synonym: "inhibition of mitochondrial DNA metabolic process" NARROW [GOC:TermGenie] synonym: "inhibition of mitochondrial DNA metabolism" EXACT [GOC:TermGenie] synonym: "inhibition of mtDNA metabolic process" EXACT [GOC:TermGenie] synonym: "inhibition of mtDNA metabolism" EXACT [GOC:TermGenie] synonym: "negative regulation of mitochondrial DNA metabolism" EXACT [GOC:TermGenie] synonym: "negative regulation of mtDNA metabolic process" EXACT [GOC:TermGenie] synonym: "negative regulation of mtDNA metabolism" EXACT [GOC:TermGenie] is_a: GO:0051053 ! negative regulation of DNA metabolic process is_a: GO:1901858 ! regulation of mitochondrial DNA metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0032042 ! negatively regulates mitochondrial DNA metabolic process relationship: RO:0002212 GO:0032042 ! negatively regulates mitochondrial DNA metabolic process creation_date: 2013-02-01T10:05:09Z [Term] id: GO:1901860 name: positive regulation of mitochondrial DNA metabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of mitochondrial DNA metabolic process." [GOC:TermGenie, GOC:yaf, PMID:23150719] synonym: "activation of mitochondrial DNA metabolic process" NARROW [GOC:TermGenie] synonym: "activation of mitochondrial DNA metabolism" EXACT [GOC:TermGenie] synonym: "activation of mtDNA metabolic process" EXACT [GOC:TermGenie] synonym: "activation of mtDNA metabolism" EXACT [GOC:TermGenie] synonym: "positive regulation of mitochondrial DNA metabolism" EXACT [GOC:TermGenie] synonym: "positive regulation of mtDNA metabolic process" EXACT [GOC:TermGenie] synonym: "positive regulation of mtDNA metabolism" EXACT [GOC:TermGenie] synonym: "up regulation of mitochondrial DNA metabolic process" EXACT [GOC:TermGenie] synonym: "up regulation of mitochondrial DNA metabolism" EXACT [GOC:TermGenie] synonym: "up regulation of mtDNA metabolic process" EXACT [GOC:TermGenie] synonym: "up regulation of mtDNA metabolism" EXACT [GOC:TermGenie] synonym: "up-regulation of mitochondrial DNA metabolic process" EXACT [GOC:TermGenie] synonym: "up-regulation of mitochondrial DNA metabolism" EXACT [GOC:TermGenie] synonym: "up-regulation of mtDNA metabolic process" EXACT [GOC:TermGenie] synonym: "up-regulation of mtDNA metabolism" EXACT [GOC:TermGenie] synonym: "upregulation of mitochondrial DNA metabolic process" EXACT [GOC:TermGenie] synonym: "upregulation of mitochondrial DNA metabolism" EXACT [GOC:TermGenie] synonym: "upregulation of mtDNA metabolic process" EXACT [GOC:TermGenie] synonym: "upregulation of mtDNA metabolism" EXACT [GOC:TermGenie] is_a: GO:0010638 ! positive regulation of organelle organization is_a: GO:0010821 ! regulation of mitochondrion organization is_a: GO:0051054 ! positive regulation of DNA metabolic process is_a: GO:1901858 ! regulation of mitochondrial DNA metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0032042 ! positively regulates mitochondrial DNA metabolic process relationship: RO:0002213 GO:0007005 {IAO:0000233="https://github.com/geneontology/go-ontology/issues/13926"} ! positively regulates mitochondrion organization relationship: RO:0002213 GO:0032042 ! positively regulates mitochondrial DNA metabolic process creation_date: 2013-02-01T10:05:14Z [Term] id: GO:1901861 name: regulation of muscle tissue development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of muscle tissue development." [GOC:TermGenie, GOC:yaf, PMID:23150719] is_a: GO:0050793 ! regulation of developmental process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0060537 ! regulates muscle tissue development relationship: RO:0002211 GO:0060537 ! regulates muscle tissue development creation_date: 2013-02-01T10:30:47Z [Term] id: GO:1901862 name: negative regulation of muscle tissue development namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of muscle tissue development." [GOC:TermGenie, GOC:yaf, PMID:23150719] synonym: "down regulation of muscle tissue development" EXACT [GOC:TermGenie] synonym: "down-regulation of muscle tissue development" EXACT [GOC:TermGenie] synonym: "downregulation of muscle tissue development" EXACT [GOC:TermGenie] synonym: "inhibition of muscle tissue development" NARROW [GOC:TermGenie] is_a: GO:0051093 ! negative regulation of developmental process is_a: GO:1901861 ! regulation of muscle tissue development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0060537 ! negatively regulates muscle tissue development relationship: RO:0002212 GO:0060537 ! negatively regulates muscle tissue development creation_date: 2013-02-01T10:30:52Z [Term] id: GO:1901863 name: positive regulation of muscle tissue development namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of muscle tissue development." [GOC:TermGenie, GOC:yaf, PMID:23150719] synonym: "activation of muscle tissue development" NARROW [GOC:TermGenie] synonym: "up regulation of muscle tissue development" EXACT [GOC:TermGenie] synonym: "up-regulation of muscle tissue development" EXACT [GOC:TermGenie] synonym: "upregulation of muscle tissue development" EXACT [GOC:TermGenie] is_a: GO:0051094 ! positive regulation of developmental process is_a: GO:1901861 ! regulation of muscle tissue development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0060537 ! positively regulates muscle tissue development relationship: RO:0002213 GO:0060537 ! positively regulates muscle tissue development creation_date: 2013-02-01T10:30:57Z [Term] id: GO:1901876 name: regulation of calcium ion binding namespace: biological_process def: "Any process that modulates the frequency, rate or extent of calcium ion binding." [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:16432188] subset: gocheck_do_not_annotate synonym: "regulation of calcium ion storage activity" RELATED [GOC:TermGenie] is_a: GO:0051098 ! regulation of binding intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0005509 ! regulates calcium ion binding relationship: RO:0002211 GO:0005509 ! regulates calcium ion binding creation_date: 2013-02-06T12:38:12Z [Term] id: GO:1901879 name: regulation of protein depolymerization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of protein depolymerization." [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:12032137] synonym: "regulation of protein polymer breakdown" EXACT [GOC:TermGenie] synonym: "regulation of protein polymer catabolic process" EXACT [GOC:TermGenie] synonym: "regulation of protein polymer catabolism" EXACT [GOC:TermGenie] synonym: "regulation of protein polymer degradation" EXACT [GOC:TermGenie] is_a: GO:0043244 ! regulation of protein-containing complex disassembly intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0051261 ! regulates protein depolymerization relationship: RO:0002211 GO:0051261 ! regulates protein depolymerization creation_date: 2013-02-06T13:57:23Z [Term] id: GO:1901880 name: negative regulation of protein depolymerization namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein depolymerization." [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:12032137] synonym: "down regulation of protein depolymerization" EXACT [GOC:TermGenie] synonym: "down regulation of protein polymer breakdown" EXACT [GOC:TermGenie] synonym: "down regulation of protein polymer catabolic process" EXACT [GOC:TermGenie] synonym: "down regulation of protein polymer catabolism" EXACT [GOC:TermGenie] synonym: "down regulation of protein polymer degradation" EXACT [GOC:TermGenie] synonym: "down-regulation of protein depolymerization" EXACT [GOC:TermGenie] synonym: "down-regulation of protein polymer breakdown" EXACT [GOC:TermGenie] synonym: "down-regulation of protein polymer catabolic process" EXACT [GOC:TermGenie] synonym: "down-regulation of protein polymer catabolism" EXACT [GOC:TermGenie] synonym: "down-regulation of protein polymer degradation" EXACT [GOC:TermGenie] synonym: "downregulation of protein depolymerization" EXACT [GOC:TermGenie] synonym: "downregulation of protein polymer breakdown" EXACT [GOC:TermGenie] synonym: "downregulation of protein polymer catabolic process" EXACT [GOC:TermGenie] synonym: "downregulation of protein polymer catabolism" EXACT [GOC:TermGenie] synonym: "downregulation of protein polymer degradation" EXACT [GOC:TermGenie] synonym: "inhibition of protein depolymerization" NARROW [GOC:TermGenie] synonym: "inhibition of protein polymer breakdown" EXACT [GOC:TermGenie] synonym: "inhibition of protein polymer catabolic process" EXACT [GOC:TermGenie] synonym: "inhibition of protein polymer catabolism" EXACT [GOC:TermGenie] synonym: "inhibition of protein polymer degradation" EXACT [GOC:TermGenie] synonym: "negative regulation of protein polymer breakdown" EXACT [GOC:TermGenie] synonym: "negative regulation of protein polymer catabolic process" EXACT [GOC:TermGenie] synonym: "negative regulation of protein polymer catabolism" EXACT [GOC:TermGenie] synonym: "negative regulation of protein polymer degradation" EXACT [GOC:TermGenie] is_a: GO:0043242 ! negative regulation of protein-containing complex disassembly is_a: GO:1901879 ! regulation of protein depolymerization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0051261 ! negatively regulates protein depolymerization relationship: RO:0002212 GO:0051261 ! negatively regulates protein depolymerization creation_date: 2013-02-06T13:57:28Z [Term] id: GO:1901881 name: positive regulation of protein depolymerization namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of protein depolymerization." [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:12032137] synonym: "activation of protein depolymerization" NARROW [GOC:TermGenie] synonym: "activation of protein polymer breakdown" EXACT [GOC:TermGenie] synonym: "activation of protein polymer catabolic process" EXACT [GOC:TermGenie] synonym: "activation of protein polymer catabolism" EXACT [GOC:TermGenie] synonym: "activation of protein polymer degradation" EXACT [GOC:TermGenie] synonym: "positive regulation of protein polymer breakdown" EXACT [GOC:TermGenie] synonym: "positive regulation of protein polymer catabolic process" EXACT [GOC:TermGenie] synonym: "positive regulation of protein polymer catabolism" EXACT [GOC:TermGenie] synonym: "positive regulation of protein polymer degradation" EXACT [GOC:TermGenie] synonym: "up regulation of protein depolymerization" EXACT [GOC:TermGenie] synonym: "up regulation of protein polymer breakdown" EXACT [GOC:TermGenie] synonym: "up regulation of protein polymer catabolic process" EXACT [GOC:TermGenie] synonym: "up regulation of protein polymer catabolism" EXACT [GOC:TermGenie] synonym: "up regulation of protein polymer degradation" EXACT [GOC:TermGenie] synonym: "up-regulation of protein depolymerization" EXACT [GOC:TermGenie] synonym: "up-regulation of protein polymer breakdown" EXACT [GOC:TermGenie] synonym: "up-regulation of protein polymer catabolic process" EXACT [GOC:TermGenie] synonym: "up-regulation of protein polymer catabolism" EXACT [GOC:TermGenie] synonym: "up-regulation of protein polymer degradation" EXACT [GOC:TermGenie] synonym: "upregulation of protein depolymerization" EXACT [GOC:TermGenie] synonym: "upregulation of protein polymer breakdown" EXACT [GOC:TermGenie] synonym: "upregulation of protein polymer catabolic process" EXACT [GOC:TermGenie] synonym: "upregulation of protein polymer catabolism" EXACT [GOC:TermGenie] synonym: "upregulation of protein polymer degradation" EXACT [GOC:TermGenie] is_a: GO:0043243 ! positive regulation of protein-containing complex disassembly is_a: GO:1901879 ! regulation of protein depolymerization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0051261 ! positively regulates protein depolymerization relationship: RO:0002213 GO:0051261 ! positively regulates protein depolymerization creation_date: 2013-02-06T13:57:32Z [Term] id: GO:1901888 name: regulation of cell junction assembly namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cell junction assembly." [GOC:TermGenie] is_a: GO:0044087 ! regulation of cellular component biogenesis is_a: GO:0051128 ! regulation of cellular component organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0034329 ! regulates cell junction assembly relationship: RO:0002211 GO:0034329 ! regulates cell junction assembly property_value: RO:0002161 NCBITaxon:4751 creation_date: 2013-02-06T19:40:32Z [Term] id: GO:1901889 name: negative regulation of cell junction assembly namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of cell junction assembly." [GOC:TermGenie] synonym: "down regulation of cell junction assembly" EXACT [GOC:TermGenie] synonym: "down-regulation of cell junction assembly" EXACT [GOC:TermGenie] synonym: "downregulation of cell junction assembly" EXACT [GOC:TermGenie] synonym: "inhibition of cell junction assembly" NARROW [GOC:TermGenie] is_a: GO:0051129 ! negative regulation of cellular component organization is_a: GO:1901888 ! regulation of cell junction assembly intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0034329 ! negatively regulates cell junction assembly relationship: RO:0002212 GO:0034329 ! negatively regulates cell junction assembly property_value: RO:0002161 NCBITaxon:4751 creation_date: 2013-02-06T19:40:41Z [Term] id: GO:1901890 name: positive regulation of cell junction assembly namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cell junction assembly." [GOC:TermGenie] synonym: "activation of cell junction assembly" NARROW [GOC:TermGenie] synonym: "up regulation of cell junction assembly" EXACT [GOC:TermGenie] synonym: "up-regulation of cell junction assembly" EXACT [GOC:TermGenie] synonym: "upregulation of cell junction assembly" EXACT [GOC:TermGenie] is_a: GO:0044089 ! positive regulation of cellular component biogenesis is_a: GO:0051130 ! positive regulation of cellular component organization is_a: GO:1901888 ! regulation of cell junction assembly intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0034329 ! positively regulates cell junction assembly relationship: RO:0002213 GO:0034329 ! positively regulates cell junction assembly property_value: RO:0002161 NCBITaxon:4751 creation_date: 2013-02-06T19:40:46Z [Term] id: GO:1901950 name: dense core granule transport namespace: biological_process def: "The directed movement a dense core granule within a cell." [GOC:kmv, GOC:TermGenie, PMID:23358451] comment: goslim_synapse synonym: "dense core vesicle transport" EXACT [GOC:TermGenie] is_a: GO:0016482 ! cytosolic transport is_a: GO:0032253 ! dense core granule localization is_a: GO:0051650 ! establishment of vesicle localization intersection_of: GO:0006810 ! transport intersection_of: BFO:0000066 GO:0005829 ! occurs in cytosol intersection_of: RO:0004009 GO:0031045 ! has primary input dense core granule creation_date: 2013-02-19T13:00:52Z [Term] id: GO:1901951 name: regulation of anterograde dense core granule transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of anterograde dense core granule transport." [GOC:kmv, GOC:TermGenie, PMID:23358451] is_a: GO:1901608 ! regulation of vesicle transport along microtubule is_a: GO:1904809 ! regulation of dense core granule transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:1990048 ! regulates anterograde neuronal dense core vesicle transport relationship: RO:0002211 GO:1990048 ! regulates anterograde neuronal dense core vesicle transport creation_date: 2013-02-19T13:36:21Z [Term] id: GO:1901952 name: negative regulation of anterograde dense core granule transport namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of anterograde dense core granule transport." [GOC:kmv, GOC:TermGenie, PMID:23358451] synonym: "down regulation of anterograde dense core granule transport" EXACT [GOC:TermGenie] synonym: "down-regulation of anterograde dense core granule transport" EXACT [GOC:TermGenie] synonym: "downregulation of anterograde dense core granule transport" EXACT [GOC:TermGenie] synonym: "inhibition of anterograde dense core granule transport" NARROW [GOC:TermGenie] is_a: GO:1901609 ! negative regulation of vesicle transport along microtubule is_a: GO:1901951 ! regulation of anterograde dense core granule transport is_a: GO:1904810 ! negative regulation of dense core granule transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:1990048 ! negatively regulates anterograde neuronal dense core vesicle transport relationship: RO:0002212 GO:1990048 ! negatively regulates anterograde neuronal dense core vesicle transport creation_date: 2013-02-19T13:36:30Z [Term] id: GO:1901953 name: positive regulation of anterograde dense core granule transport namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of anterograde dense core granule transport." [GOC:kmv, GOC:TermGenie, PMID:23358451] synonym: "activation of anterograde dense core granule transport" NARROW [GOC:TermGenie] synonym: "up regulation of anterograde dense core granule transport" EXACT [GOC:TermGenie] synonym: "up-regulation of anterograde dense core granule transport" EXACT [GOC:TermGenie] synonym: "upregulation of anterograde dense core granule transport" EXACT [GOC:TermGenie] is_a: GO:1901610 ! positive regulation of vesicle transport along microtubule is_a: GO:1901951 ! regulation of anterograde dense core granule transport is_a: GO:1904811 ! positive regulation of dense core granule transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:1990048 ! positively regulates anterograde neuronal dense core vesicle transport relationship: RO:0002213 GO:1990048 ! positively regulates anterograde neuronal dense core vesicle transport creation_date: 2013-02-19T13:36:35Z [Term] id: GO:1901954 name: regulation of retrograde dense core granule transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of retrograde dense core granule transport." [GOC:kmv, GOC:TermGenie, PMID:23358451] is_a: GO:1901608 ! regulation of vesicle transport along microtubule is_a: GO:1904809 ! regulation of dense core granule transport is_a: GO:2001017 ! regulation of retrograde axon cargo transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:1990049 ! regulates retrograde neuronal dense core vesicle transport relationship: RO:0002211 GO:1990049 ! regulates retrograde neuronal dense core vesicle transport creation_date: 2013-02-19T13:36:43Z [Term] id: GO:1901955 name: negative regulation of retrograde dense core granule transport namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of retrograde dense core granule transport." [GOC:kmv, GOC:TermGenie, PMID:23358451] synonym: "down regulation of retrograde dense core granule transport" EXACT [GOC:TermGenie] synonym: "down-regulation of retrograde dense core granule transport" EXACT [GOC:TermGenie] synonym: "downregulation of retrograde dense core granule transport" EXACT [GOC:TermGenie] synonym: "inhibition of retrograde dense core granule transport" NARROW [GOC:TermGenie] is_a: GO:1901609 ! negative regulation of vesicle transport along microtubule is_a: GO:1901954 ! regulation of retrograde dense core granule transport is_a: GO:1904810 ! negative regulation of dense core granule transport is_a: GO:2001018 ! negative regulation of retrograde axon cargo transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:1990049 ! negatively regulates retrograde neuronal dense core vesicle transport relationship: RO:0002212 GO:1990049 ! negatively regulates retrograde neuronal dense core vesicle transport creation_date: 2013-02-19T13:36:47Z [Term] id: GO:1901956 name: positive regulation of retrograde dense core granule transport namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of retrograde dense core granule transport." [GOC:kmv, GOC:TermGenie, PMID:23358451] synonym: "activation of retrograde dense core granule transport" NARROW [GOC:TermGenie] synonym: "up regulation of retrograde dense core granule transport" EXACT [GOC:TermGenie] synonym: "up-regulation of retrograde dense core granule transport" EXACT [GOC:TermGenie] synonym: "upregulation of retrograde dense core granule transport" EXACT [GOC:TermGenie] is_a: GO:1901610 ! positive regulation of vesicle transport along microtubule is_a: GO:1901954 ! regulation of retrograde dense core granule transport is_a: GO:1904811 ! positive regulation of dense core granule transport is_a: GO:2001019 ! positive regulation of retrograde axon cargo transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:1990049 ! positively regulates retrograde neuronal dense core vesicle transport relationship: RO:0002213 GO:1990049 ! positively regulates retrograde neuronal dense core vesicle transport creation_date: 2013-02-19T13:36:52Z [Term] id: GO:1901963 name: regulation of cell proliferation involved in outflow tract morphogenesis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cell proliferation involved in outflow tract morphogenesis." [GOC:dph, GOC:mtg_heart, GOC:TermGenie, PMID:21419760] is_a: GO:2000136 ! regulation of cell proliferation involved in heart morphogenesis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0061325 ! regulates cell proliferation involved in outflow tract morphogenesis relationship: RO:0002211 GO:0061325 ! regulates cell proliferation involved in outflow tract morphogenesis creation_date: 2013-02-20T20:30:26Z [Term] id: GO:1901964 name: positive regulation of cell proliferation involved in outflow tract morphogenesis namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cell proliferation involved in outflow tract morphogenesis." [GOC:dph, GOC:mtg_heart, GOC:TermGenie, PMID:21419760] synonym: "activation of cell proliferation involved in outflow tract morphogenesis" NARROW [GOC:TermGenie] synonym: "up regulation of cell proliferation involved in outflow tract morphogenesis" EXACT [GOC:TermGenie] synonym: "up-regulation of cell proliferation involved in outflow tract morphogenesis" EXACT [GOC:TermGenie] synonym: "upregulation of cell proliferation involved in outflow tract morphogenesis" EXACT [GOC:TermGenie] is_a: GO:1901963 ! regulation of cell proliferation involved in outflow tract morphogenesis is_a: GO:2000138 ! positive regulation of cell proliferation involved in heart morphogenesis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0061325 ! positively regulates cell proliferation involved in outflow tract morphogenesis relationship: RO:0002213 GO:0061325 ! positively regulates cell proliferation involved in outflow tract morphogenesis creation_date: 2013-02-20T20:30:31Z [Term] id: GO:1902001 name: fatty acid transmembrane transport namespace: biological_process def: "The process in which a fatty acid is transported across a membrane." [GOC:rb, GOC:TermGenie, PMID:9395310] is_a: GO:0015908 ! fatty acid transport is_a: GO:1905039 ! carboxylic acid transmembrane transport intersection_of: GO:0055085 ! transmembrane transport intersection_of: RO:0004009 CHEBI:28868 ! has primary input creation_date: 2013-03-21T09:57:00Z [Term] id: GO:1902017 name: regulation of cilium assembly namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cilium assembly." [GOC:cilia, GOC:dph, GOC:TermGenie, PMID:17719545] synonym: "regulation of ciliogenesis" EXACT [GOC:TermGenie] synonym: "regulation of cilium biogenesis" RELATED [GOC:TermGenie] is_a: GO:0120032 ! regulation of plasma membrane bounded cell projection assembly is_a: GO:1902115 ! regulation of organelle assembly intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0060271 ! regulates cilium assembly relationship: RO:0002211 GO:0060271 ! regulates cilium assembly property_value: RO:0002161 NCBITaxon:3176 property_value: RO:0002161 NCBITaxon:3378 property_value: RO:0002161 NCBITaxon:3398 property_value: RO:0002161 NCBITaxon:4751 property_value: RO:0002161 NCBITaxon:5782 creation_date: 2013-03-26T18:10:51Z [Term] id: GO:1902018 name: negative regulation of cilium assembly namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of cilium assembly." [GOC:cilia, GOC:dph, GOC:TermGenie, PMID:17719545] synonym: "down regulation of ciliogenesis" EXACT [GOC:TermGenie] synonym: "down regulation of cilium assembly" EXACT [GOC:TermGenie] synonym: "down regulation of cilium biogenesis" RELATED [GOC:TermGenie] synonym: "down-regulation of ciliogenesis" EXACT [GOC:TermGenie] synonym: "down-regulation of cilium assembly" EXACT [GOC:TermGenie] synonym: "down-regulation of cilium biogenesis" RELATED [GOC:TermGenie] synonym: "downregulation of ciliogenesis" EXACT [GOC:TermGenie] synonym: "downregulation of cilium assembly" EXACT [GOC:TermGenie] synonym: "downregulation of cilium biogenesis" RELATED [GOC:TermGenie] synonym: "inhibition of ciliogenesis" EXACT [GOC:TermGenie] synonym: "inhibition of cilium assembly" NARROW [GOC:TermGenie] synonym: "inhibition of cilium biogenesis" RELATED [GOC:TermGenie] synonym: "negative regulation of ciliogenesis" EXACT [GOC:TermGenie] synonym: "negative regulation of cilium biogenesis" RELATED [GOC:TermGenie] is_a: GO:0120033 ! negative regulation of plasma membrane bounded cell projection assembly is_a: GO:1902017 ! regulation of cilium assembly is_a: GO:1902116 ! negative regulation of organelle assembly intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0060271 ! negatively regulates cilium assembly relationship: RO:0002212 GO:0060271 ! negatively regulates cilium assembly property_value: RO:0002161 NCBITaxon:3176 property_value: RO:0002161 NCBITaxon:3378 property_value: RO:0002161 NCBITaxon:3398 property_value: RO:0002161 NCBITaxon:4751 property_value: RO:0002161 NCBITaxon:5782 creation_date: 2013-03-26T18:10:56Z [Term] id: GO:1902019 name: regulation of cilium-dependent cell motility namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cilium-dependent cell motility." [GOC:cilia, GOC:jl, GOC:TermGenie] synonym: "regulation of ciliary cell motility" RELATED [] synonym: "regulation of cilium cell motility" EXACT [] is_a: GO:2000145 ! regulation of cell motility intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0060285 ! regulates cilium-dependent cell motility relationship: RO:0002211 GO:0060285 ! regulates cilium-dependent cell motility property_value: RO:0002161 NCBITaxon:3176 property_value: RO:0002161 NCBITaxon:3378 property_value: RO:0002161 NCBITaxon:3398 property_value: RO:0002161 NCBITaxon:451864 property_value: RO:0002161 NCBITaxon:5782 creation_date: 2013-03-27T14:42:38Z [Term] id: GO:1902020 name: negative regulation of cilium-dependent cell motility namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of cilium-dependent cell motility." [GOC:cilia, GOC:jl, GOC:TermGenie] synonym: "down regulation of ciliary cell motility" EXACT [GOC:TermGenie] synonym: "down-regulation of ciliary cell motility" EXACT [GOC:TermGenie] synonym: "downregulation of ciliary cell motility" EXACT [GOC:TermGenie] synonym: "inhibition of ciliary cell motility" NARROW [GOC:TermGenie] synonym: "negative regulation of ciliary cell motility" RELATED [] synonym: "negative regulation of cilium cell motility" EXACT [] is_a: GO:1902019 ! regulation of cilium-dependent cell motility is_a: GO:2000146 ! negative regulation of cell motility intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0060285 ! negatively regulates cilium-dependent cell motility relationship: RO:0002212 GO:0060285 ! negatively regulates cilium-dependent cell motility property_value: RO:0002161 NCBITaxon:3176 property_value: RO:0002161 NCBITaxon:3378 property_value: RO:0002161 NCBITaxon:3398 property_value: RO:0002161 NCBITaxon:451864 property_value: RO:0002161 NCBITaxon:5782 creation_date: 2013-03-27T14:42:42Z [Term] id: GO:1902024 name: L-histidine transport namespace: biological_process def: "The directed movement of a L-histidine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:kmv, GOC:TermGenie, PMID:22822152] is_a: GO:0015695 ! organic cation transport is_a: GO:0015801 ! aromatic amino acid transport is_a: GO:0015802 ! basic amino acid transport is_a: GO:0015807 ! L-amino acid transport intersection_of: GO:0015802 ! basic amino acid transport intersection_of: RO:0004009 CHEBI:57595 ! has primary input relationship: RO:0004009 CHEBI:57595 ! has primary input creation_date: 2013-03-27T16:09:15Z [Term] id: GO:1902033 name: regulation of hematopoietic stem cell proliferation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of hematopoietic stem cell proliferation." [GOC:TermGenie, PMID:23403623] synonym: "regulation of hemopoietic stem cell proliferation" EXACT [GOC:TermGenie] is_a: GO:0072091 ! regulation of stem cell proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0071425 ! regulates hematopoietic stem cell proliferation relationship: RO:0002211 GO:0071425 ! regulates hematopoietic stem cell proliferation creation_date: 2013-04-02T05:13:19Z [Term] id: GO:1902034 name: negative regulation of hematopoietic stem cell proliferation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of hematopoietic stem cell proliferation." [GOC:TermGenie, PMID:23403623] synonym: "down regulation of hematopoietic stem cell proliferation" EXACT [GOC:TermGenie] synonym: "down regulation of hemopoietic stem cell proliferation" EXACT [GOC:TermGenie] synonym: "down-regulation of hematopoietic stem cell proliferation" EXACT [GOC:TermGenie] synonym: "down-regulation of hemopoietic stem cell proliferation" EXACT [GOC:TermGenie] synonym: "downregulation of hematopoietic stem cell proliferation" EXACT [GOC:TermGenie] synonym: "downregulation of hemopoietic stem cell proliferation" EXACT [GOC:TermGenie] synonym: "inhibition of hematopoietic stem cell proliferation" NARROW [GOC:TermGenie] synonym: "inhibition of hemopoietic stem cell proliferation" NARROW [GOC:TermGenie] synonym: "negative regulation of hemopoietic stem cell proliferation" EXACT [GOC:TermGenie] is_a: GO:1902033 ! regulation of hematopoietic stem cell proliferation is_a: GO:1903707 ! negative regulation of hemopoiesis is_a: GO:2000647 ! negative regulation of stem cell proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0071425 ! negatively regulates hematopoietic stem cell proliferation relationship: RO:0002212 GO:0071425 ! negatively regulates hematopoietic stem cell proliferation creation_date: 2013-04-02T05:13:24Z [Term] id: GO:1902035 name: positive regulation of hematopoietic stem cell proliferation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of hematopoietic stem cell proliferation." [GOC:TermGenie, PMID:23403623] synonym: "activation of hematopoietic stem cell proliferation" NARROW [GOC:TermGenie] synonym: "activation of hemopoietic stem cell proliferation" NARROW [GOC:TermGenie] synonym: "positive regulation of hemopoietic stem cell proliferation" EXACT [GOC:TermGenie] synonym: "up regulation of hematopoietic stem cell proliferation" EXACT [GOC:TermGenie] synonym: "up regulation of hemopoietic stem cell proliferation" EXACT [GOC:TermGenie] synonym: "up-regulation of hematopoietic stem cell proliferation" EXACT [GOC:TermGenie] synonym: "up-regulation of hemopoietic stem cell proliferation" EXACT [GOC:TermGenie] synonym: "upregulation of hematopoietic stem cell proliferation" EXACT [GOC:TermGenie] synonym: "upregulation of hemopoietic stem cell proliferation" EXACT [GOC:TermGenie] is_a: GO:1902033 ! regulation of hematopoietic stem cell proliferation is_a: GO:2000648 ! positive regulation of stem cell proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0071425 ! positively regulates hematopoietic stem cell proliferation relationship: RO:0002213 GO:0071425 ! positively regulates hematopoietic stem cell proliferation creation_date: 2013-04-02T05:13:31Z [Term] id: GO:1902036 name: regulation of hematopoietic stem cell differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of hematopoietic stem cell differentiation." [GOC:TermGenie, PMID:23403623] synonym: "regulation of haematopoietic stem cell differentiation" EXACT [GOC:TermGenie] synonym: "regulation of haemopoietic stem cell differentiation" EXACT [GOC:TermGenie] synonym: "regulation of hemopoietic stem cell differentiation" EXACT [GOC:TermGenie] xref: Reactome:R-HSA-8939236 "RUNX1 regulates transcription of genes involved in differentiation of HSCs" is_a: GO:1901532 ! regulation of hematopoietic progenitor cell differentiation is_a: GO:2000736 ! regulation of stem cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0060218 ! regulates hematopoietic stem cell differentiation relationship: RO:0002211 GO:0060218 ! regulates hematopoietic stem cell differentiation creation_date: 2013-04-02T05:19:09Z [Term] id: GO:1902037 name: negative regulation of hematopoietic stem cell differentiation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of hematopoietic stem cell differentiation." [GOC:TermGenie, PMID:23403623] synonym: "down regulation of haematopoietic stem cell differentiation" EXACT [GOC:TermGenie] synonym: "down regulation of haemopoietic stem cell differentiation" EXACT [GOC:TermGenie] synonym: "down regulation of hematopoietic stem cell differentiation" EXACT [GOC:TermGenie] synonym: "down regulation of hemopoietic stem cell differentiation" EXACT [GOC:TermGenie] synonym: "down-regulation of haematopoietic stem cell differentiation" EXACT [GOC:TermGenie] synonym: "down-regulation of haemopoietic stem cell differentiation" EXACT [GOC:TermGenie] synonym: "down-regulation of hematopoietic stem cell differentiation" EXACT [GOC:TermGenie] synonym: "down-regulation of hemopoietic stem cell differentiation" EXACT [GOC:TermGenie] synonym: "downregulation of haematopoietic stem cell differentiation" EXACT [GOC:TermGenie] synonym: "downregulation of haemopoietic stem cell differentiation" EXACT [GOC:TermGenie] synonym: "downregulation of hematopoietic stem cell differentiation" EXACT [GOC:TermGenie] synonym: "downregulation of hemopoietic stem cell differentiation" EXACT [GOC:TermGenie] synonym: "inhibition of haematopoietic stem cell differentiation" NARROW [GOC:TermGenie] synonym: "inhibition of haemopoietic stem cell differentiation" NARROW [GOC:TermGenie] synonym: "inhibition of hematopoietic stem cell differentiation" NARROW [GOC:TermGenie] synonym: "inhibition of hemopoietic stem cell differentiation" NARROW [GOC:TermGenie] synonym: "negative regulation of haematopoietic stem cell differentiation" EXACT [GOC:TermGenie] synonym: "negative regulation of haemopoietic stem cell differentiation" EXACT [GOC:TermGenie] synonym: "negative regulation of hemopoietic stem cell differentiation" EXACT [GOC:TermGenie] is_a: GO:1901533 ! negative regulation of hematopoietic progenitor cell differentiation is_a: GO:1902036 ! regulation of hematopoietic stem cell differentiation is_a: GO:2000737 ! negative regulation of stem cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0060218 ! negatively regulates hematopoietic stem cell differentiation relationship: RO:0002212 GO:0060218 ! negatively regulates hematopoietic stem cell differentiation creation_date: 2013-04-02T05:19:14Z [Term] id: GO:1902038 name: positive regulation of hematopoietic stem cell differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of hematopoietic stem cell differentiation." [GOC:TermGenie, PMID:23403623] synonym: "activation of haematopoietic stem cell differentiation" NARROW [GOC:TermGenie] synonym: "activation of haemopoietic stem cell differentiation" NARROW [GOC:TermGenie] synonym: "activation of hematopoietic stem cell differentiation" NARROW [GOC:TermGenie] synonym: "activation of hemopoietic stem cell differentiation" NARROW [GOC:TermGenie] synonym: "positive regulation of haematopoietic stem cell differentiation" EXACT [GOC:TermGenie] synonym: "positive regulation of haemopoietic stem cell differentiation" EXACT [GOC:TermGenie] synonym: "positive regulation of hemopoietic stem cell differentiation" EXACT [GOC:TermGenie] synonym: "up regulation of haematopoietic stem cell differentiation" EXACT [GOC:TermGenie] synonym: "up regulation of haemopoietic stem cell differentiation" EXACT [GOC:TermGenie] synonym: "up regulation of hematopoietic stem cell differentiation" EXACT [GOC:TermGenie] synonym: "up regulation of hemopoietic stem cell differentiation" EXACT [GOC:TermGenie] synonym: "up-regulation of haematopoietic stem cell differentiation" EXACT [GOC:TermGenie] synonym: "up-regulation of haemopoietic stem cell differentiation" EXACT [GOC:TermGenie] synonym: "up-regulation of hematopoietic stem cell differentiation" EXACT [GOC:TermGenie] synonym: "up-regulation of hemopoietic stem cell differentiation" EXACT [GOC:TermGenie] synonym: "upregulation of haematopoietic stem cell differentiation" EXACT [GOC:TermGenie] synonym: "upregulation of haemopoietic stem cell differentiation" EXACT [GOC:TermGenie] synonym: "upregulation of hematopoietic stem cell differentiation" EXACT [GOC:TermGenie] synonym: "upregulation of hemopoietic stem cell differentiation" EXACT [GOC:TermGenie] is_a: GO:1901534 ! positive regulation of hematopoietic progenitor cell differentiation is_a: GO:1902036 ! regulation of hematopoietic stem cell differentiation is_a: GO:2000738 ! positive regulation of stem cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0060218 ! positively regulates hematopoietic stem cell differentiation relationship: RO:0002213 GO:0060218 ! positively regulates hematopoietic stem cell differentiation creation_date: 2013-04-02T05:19:19Z [Term] id: GO:1902065 name: response to L-glutamate namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an L-glutamate stimulus." [GOC:TermGenie, PMID:23574009] is_a: GO:0043200 ! response to amino acid is_a: GO:1901698 ! response to nitrogen compound is_a: GO:1901700 ! response to oxygen-containing compound intersection_of: GO:0050896 ! response to stimulus intersection_of: RO:0004009 CHEBI:29985 ! has primary input relationship: RO:0004009 CHEBI:29985 ! has primary input creation_date: 2013-04-16T21:21:14Z [Term] id: GO:1902076 name: regulation of lateral motor column neuron migration namespace: biological_process def: "Any process that modulates the frequency, rate or extent of lateral motor column neuron migration." [GOC:TermGenie, GOC:yaf, PMID:20711475] is_a: GO:1905483 ! regulation of motor neuron migration intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0097477 ! regulates lateral motor column neuron migration relationship: RO:0002211 GO:0097477 ! regulates lateral motor column neuron migration creation_date: 2013-04-23T14:42:18Z [Term] id: GO:1902077 name: negative regulation of lateral motor column neuron migration namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of lateral motor column neuron migration." [GOC:TermGenie, GOC:yaf, PMID:20711475] synonym: "down regulation of lateral motor column neuron migration" EXACT [GOC:TermGenie] synonym: "down-regulation of lateral motor column neuron migration" EXACT [GOC:TermGenie] synonym: "downregulation of lateral motor column neuron migration" EXACT [GOC:TermGenie] synonym: "inhibition of lateral motor column neuron migration" NARROW [GOC:TermGenie] is_a: GO:1902076 ! regulation of lateral motor column neuron migration is_a: GO:1905484 ! negative regulation of motor neuron migration intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0097477 ! negatively regulates lateral motor column neuron migration relationship: RO:0002212 GO:0097477 ! negatively regulates lateral motor column neuron migration creation_date: 2013-04-23T14:42:23Z [Term] id: GO:1902078 name: positive regulation of lateral motor column neuron migration namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of lateral motor column neuron migration." [GOC:TermGenie, GOC:yaf, PMID:20711475] synonym: "activation of lateral motor column neuron migration" NARROW [GOC:TermGenie] synonym: "up regulation of lateral motor column neuron migration" EXACT [GOC:TermGenie] synonym: "up-regulation of lateral motor column neuron migration" EXACT [GOC:TermGenie] synonym: "upregulation of lateral motor column neuron migration" EXACT [GOC:TermGenie] is_a: GO:1902076 ! regulation of lateral motor column neuron migration is_a: GO:1905485 ! positive regulation of motor neuron migration intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0097477 ! positively regulates lateral motor column neuron migration relationship: RO:0002213 GO:0097477 ! positively regulates lateral motor column neuron migration creation_date: 2013-04-23T14:42:28Z [Term] id: GO:1902093 name: positive regulation of flagellated sperm motility namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of flagellated sperm motility." [GOC:cilia, GOC:jh2, GOC:krc, GOC:TermGenie, PMID:7513657] synonym: "activation of sperm motility" NARROW [GOC:TermGenie] synonym: "activation of sperm movement" BROAD [GOC:TermGenie] synonym: "positive regulation of sperm motility" BROAD [] synonym: "positive regulation of sperm movement" BROAD [GOC:TermGenie] synonym: "up regulation of sperm motility" BROAD [GOC:TermGenie] synonym: "up regulation of sperm movement" BROAD [GOC:TermGenie] synonym: "up-regulation of sperm motility" BROAD [GOC:TermGenie] synonym: "up-regulation of sperm movement" BROAD [GOC:TermGenie] synonym: "upregulation of sperm motility" BROAD [GOC:TermGenie] synonym: "upregulation of sperm movement" BROAD [GOC:TermGenie] is_a: GO:0003353 ! positive regulation of cilium movement is_a: GO:1901317 ! regulation of flagellated sperm motility is_a: GO:2000155 ! positive regulation of cilium-dependent cell motility is_a: GO:2000243 ! positive regulation of reproductive process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0030317 ! positively regulates flagellated sperm motility relationship: RO:0002213 GO:0030317 ! positively regulates flagellated sperm motility property_value: RO:0002161 NCBITaxon:3176 property_value: RO:0002161 NCBITaxon:3378 property_value: RO:0002161 NCBITaxon:3398 property_value: RO:0002161 NCBITaxon:451864 property_value: RO:0002161 NCBITaxon:5782 creation_date: 2013-04-29T09:15:25Z [Term] id: GO:1902105 name: regulation of leukocyte differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of leukocyte differentiation." [GOC:add, GOC:TermGenie] synonym: "regulation of immune cell differentiation" EXACT [GOC:TermGenie] synonym: "regulation of leucocyte differentiation" EXACT [GOC:TermGenie] is_a: GO:1903706 ! regulation of hemopoiesis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0002521 ! regulates leukocyte differentiation relationship: RO:0002211 GO:0002521 ! regulates leukocyte differentiation creation_date: 2013-05-02T17:32:42Z [Term] id: GO:1902106 name: negative regulation of leukocyte differentiation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of leukocyte differentiation." [GOC:add, GOC:TermGenie] synonym: "down regulation of immune cell differentiation" EXACT [GOC:TermGenie] synonym: "down regulation of leucocyte differentiation" EXACT [GOC:TermGenie] synonym: "down regulation of leukocyte differentiation" EXACT [GOC:TermGenie] synonym: "down-regulation of immune cell differentiation" EXACT [GOC:TermGenie] synonym: "down-regulation of leucocyte differentiation" EXACT [GOC:TermGenie] synonym: "down-regulation of leukocyte differentiation" EXACT [GOC:TermGenie] synonym: "downregulation of immune cell differentiation" EXACT [GOC:TermGenie] synonym: "downregulation of leucocyte differentiation" EXACT [GOC:TermGenie] synonym: "downregulation of leukocyte differentiation" EXACT [GOC:TermGenie] synonym: "inhibition of immune cell differentiation" NARROW [GOC:TermGenie] synonym: "inhibition of leucocyte differentiation" NARROW [GOC:TermGenie] synonym: "inhibition of leukocyte differentiation" NARROW [GOC:TermGenie] synonym: "negative regulation of immune cell differentiation" EXACT [GOC:TermGenie] synonym: "negative regulation of leucocyte differentiation" EXACT [GOC:TermGenie] is_a: GO:1902105 ! regulation of leukocyte differentiation is_a: GO:1903707 ! negative regulation of hemopoiesis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0002521 ! negatively regulates leukocyte differentiation relationship: RO:0002212 GO:0002521 ! negatively regulates leukocyte differentiation creation_date: 2013-05-02T17:32:47Z [Term] id: GO:1902107 name: positive regulation of leukocyte differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of leukocyte differentiation." [GOC:add, GOC:TermGenie] synonym: "activation of immune cell differentiation" NARROW [GOC:TermGenie] synonym: "activation of leucocyte differentiation" NARROW [GOC:TermGenie] synonym: "activation of leukocyte differentiation" NARROW [GOC:TermGenie] synonym: "positive regulation of immune cell differentiation" EXACT [GOC:TermGenie] synonym: "positive regulation of leucocyte differentiation" EXACT [GOC:TermGenie] synonym: "up regulation of immune cell differentiation" EXACT [GOC:TermGenie] synonym: "up regulation of leucocyte differentiation" EXACT [GOC:TermGenie] synonym: "up regulation of leukocyte differentiation" EXACT [GOC:TermGenie] synonym: "up-regulation of immune cell differentiation" EXACT [GOC:TermGenie] synonym: "up-regulation of leucocyte differentiation" EXACT [GOC:TermGenie] synonym: "up-regulation of leukocyte differentiation" EXACT [GOC:TermGenie] synonym: "upregulation of immune cell differentiation" EXACT [GOC:TermGenie] synonym: "upregulation of leucocyte differentiation" EXACT [GOC:TermGenie] synonym: "upregulation of leukocyte differentiation" EXACT [GOC:TermGenie] is_a: GO:1902105 ! regulation of leukocyte differentiation is_a: GO:1903708 ! positive regulation of hemopoiesis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0002521 ! positively regulates leukocyte differentiation relationship: RO:0002213 GO:0002521 ! positively regulates leukocyte differentiation creation_date: 2013-05-02T17:32:52Z [Term] id: GO:1902115 name: regulation of organelle assembly namespace: biological_process def: "Any process that modulates the frequency, rate or extent of organelle assembly." [GOC:pr, GOC:TermGenie] is_a: GO:0033043 ! regulation of organelle organization is_a: GO:0044087 ! regulation of cellular component biogenesis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0070925 ! regulates organelle assembly relationship: RO:0002211 GO:0070925 ! regulates organelle assembly creation_date: 2013-05-14T09:43:21Z [Term] id: GO:1902116 name: negative regulation of organelle assembly namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of organelle assembly." [GOC:pr, GOC:TermGenie] synonym: "down regulation of organelle assembly" EXACT [GOC:TermGenie] synonym: "down-regulation of organelle assembly" EXACT [GOC:TermGenie] synonym: "downregulation of organelle assembly" EXACT [GOC:TermGenie] synonym: "inhibition of organelle assembly" NARROW [GOC:TermGenie] is_a: GO:0010639 ! negative regulation of organelle organization is_a: GO:1902115 ! regulation of organelle assembly intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0070925 ! negatively regulates organelle assembly relationship: RO:0002212 GO:0070925 ! negatively regulates organelle assembly creation_date: 2013-05-14T09:43:31Z [Term] id: GO:1902117 name: positive regulation of organelle assembly namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of organelle assembly." [GOC:pr, GOC:TermGenie] synonym: "activation of organelle assembly" NARROW [GOC:TermGenie] synonym: "up regulation of organelle assembly" EXACT [GOC:TermGenie] synonym: "up-regulation of organelle assembly" EXACT [GOC:TermGenie] synonym: "upregulation of organelle assembly" EXACT [GOC:TermGenie] is_a: GO:0010638 ! positive regulation of organelle organization is_a: GO:0044089 ! positive regulation of cellular component biogenesis is_a: GO:1902115 ! regulation of organelle assembly intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0070925 ! positively regulates organelle assembly relationship: RO:0002213 GO:0070925 ! positively regulates organelle assembly creation_date: 2013-05-14T09:43:36Z [Term] id: GO:1902170 name: cellular response to reactive nitrogen species namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a reactive nitrogen species stimulus." [GOC:sl, GOC:TermGenie, PMID:22504638] is_a: GO:1901699 ! cellular response to nitrogen compound intersection_of: GO:0070887 ! cellular response to chemical stimulus intersection_of: RO:0004009 CHEBI:62764 ! has primary input relationship: RO:0004009 CHEBI:62764 ! has primary input creation_date: 2013-05-23T00:23:59Z [Term] id: GO:1902172 name: regulation of keratinocyte apoptotic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of keratinocyte apoptotic process." [GOC:BHF, GOC:mtg_apoptosis, GOC:rl, GOC:TermGenie, PMID:18938133] synonym: "regulation of keratinocyte apoptosis" NARROW [GOC:TermGenie] is_a: GO:1904035 ! regulation of epithelial cell apoptotic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0097283 ! regulates keratinocyte apoptotic process relationship: RO:0002211 GO:0097283 ! regulates keratinocyte apoptotic process property_value: RO:0002161 NCBITaxon:4751 property_value: RO:0002161 NCBITaxon:6656 creation_date: 2013-05-29T14:36:11Z [Term] id: GO:1902173 name: negative regulation of keratinocyte apoptotic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of keratinocyte apoptotic process." [GOC:BHF, GOC:mtg_apoptosis, GOC:rl, GOC:TermGenie, PMID:18938133] synonym: "down regulation of keratinocyte apoptosis" NARROW [GOC:TermGenie] synonym: "down regulation of keratinocyte apoptotic process" EXACT [GOC:TermGenie] synonym: "down-regulation of keratinocyte apoptosis" NARROW [GOC:TermGenie] synonym: "down-regulation of keratinocyte apoptotic process" EXACT [GOC:TermGenie] synonym: "downregulation of keratinocyte apoptosis" NARROW [GOC:TermGenie] synonym: "downregulation of keratinocyte apoptotic process" EXACT [GOC:TermGenie] synonym: "inhibition of keratinocyte apoptosis" NARROW [GOC:TermGenie] synonym: "inhibition of keratinocyte apoptotic process" NARROW [GOC:TermGenie] synonym: "negative regulation of keratinocyte apoptosis" NARROW [GOC:TermGenie] is_a: GO:1902172 ! regulation of keratinocyte apoptotic process is_a: GO:1904036 ! negative regulation of epithelial cell apoptotic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0097283 ! negatively regulates keratinocyte apoptotic process relationship: RO:0002212 GO:0097283 ! negatively regulates keratinocyte apoptotic process property_value: RO:0002161 NCBITaxon:4751 property_value: RO:0002161 NCBITaxon:6656 creation_date: 2013-05-29T14:36:15Z [Term] id: GO:1902174 name: positive regulation of keratinocyte apoptotic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of keratinocyte apoptotic process." [GOC:BHF, GOC:mtg_apoptosis, GOC:rl, GOC:TermGenie, PMID:18938133] synonym: "activation of keratinocyte apoptosis" NARROW [GOC:TermGenie] synonym: "activation of keratinocyte apoptotic process" NARROW [GOC:TermGenie] synonym: "positive regulation of keratinocyte apoptosis" NARROW [GOC:TermGenie] synonym: "up regulation of keratinocyte apoptosis" NARROW [GOC:TermGenie] synonym: "up regulation of keratinocyte apoptotic process" EXACT [GOC:TermGenie] synonym: "up-regulation of keratinocyte apoptosis" NARROW [GOC:TermGenie] synonym: "up-regulation of keratinocyte apoptotic process" EXACT [GOC:TermGenie] synonym: "upregulation of keratinocyte apoptosis" NARROW [GOC:TermGenie] synonym: "upregulation of keratinocyte apoptotic process" EXACT [GOC:TermGenie] is_a: GO:1902172 ! regulation of keratinocyte apoptotic process is_a: GO:1904037 ! positive regulation of epithelial cell apoptotic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0097283 ! positively regulates keratinocyte apoptotic process relationship: RO:0002213 GO:0097283 ! positively regulates keratinocyte apoptotic process property_value: RO:0002161 NCBITaxon:4751 property_value: RO:0002161 NCBITaxon:6656 creation_date: 2013-05-29T14:36:21Z [Term] id: GO:1902211 name: regulation of prolactin signaling pathway namespace: biological_process def: "Any process that modulates the frequency, rate or extent of prolactin signaling pathway." [GOC:TermGenie, PMID:11773439] synonym: "regulation of PRL signaling pathway" EXACT [GOC:TermGenie] synonym: "regulation of prolactin-mediated signaling pathway" EXACT [GOC:TermGenie] is_a: GO:0001959 ! regulation of cytokine-mediated signaling pathway intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0038161 ! regulates prolactin signaling pathway relationship: RO:0002211 GO:0038161 ! regulates prolactin signaling pathway property_value: RO:0002161 NCBITaxon:4751 creation_date: 2013-06-12T10:10:07Z [Term] id: GO:1902212 name: negative regulation of prolactin signaling pathway namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of prolactin signaling pathway." [GOC:TermGenie, PMID:11773439] synonym: "down regulation of PRL signaling pathway" EXACT [GOC:TermGenie] synonym: "down regulation of prolactin signaling pathway" EXACT [GOC:TermGenie] synonym: "down regulation of prolactin-mediated signaling pathway" EXACT [GOC:TermGenie] synonym: "down-regulation of PRL signaling pathway" EXACT [GOC:TermGenie] synonym: "down-regulation of prolactin signaling pathway" EXACT [GOC:TermGenie] synonym: "down-regulation of prolactin-mediated signaling pathway" EXACT [GOC:TermGenie] synonym: "downregulation of PRL signaling pathway" EXACT [GOC:TermGenie] synonym: "downregulation of prolactin signaling pathway" EXACT [GOC:TermGenie] synonym: "downregulation of prolactin-mediated signaling pathway" EXACT [GOC:TermGenie] synonym: "inhibition of PRL signaling pathway" NARROW [GOC:TermGenie] synonym: "inhibition of prolactin signaling pathway" NARROW [GOC:TermGenie] synonym: "inhibition of prolactin-mediated signaling pathway" NARROW [GOC:TermGenie] synonym: "negative regulation of PRL signaling pathway" EXACT [GOC:TermGenie] synonym: "negative regulation of prolactin-mediated signaling pathway" EXACT [GOC:TermGenie] is_a: GO:0001960 ! negative regulation of cytokine-mediated signaling pathway is_a: GO:1902211 ! regulation of prolactin signaling pathway intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0038161 ! negatively regulates prolactin signaling pathway relationship: RO:0002212 GO:0038161 ! negatively regulates prolactin signaling pathway property_value: RO:0002161 NCBITaxon:4751 creation_date: 2013-06-12T10:10:12Z [Term] id: GO:1902213 name: positive regulation of prolactin signaling pathway namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of prolactin signaling pathway." [GOC:TermGenie, PMID:11773439] synonym: "activation of PRL signaling pathway" NARROW [GOC:TermGenie] synonym: "activation of prolactin signaling pathway" NARROW [GOC:TermGenie] synonym: "activation of prolactin-mediated signaling pathway" NARROW [GOC:TermGenie] synonym: "positive regulation of PRL signaling pathway" EXACT [GOC:TermGenie] synonym: "positive regulation of prolactin-mediated signaling pathway" EXACT [GOC:TermGenie] synonym: "up regulation of PRL signaling pathway" EXACT [GOC:TermGenie] synonym: "up regulation of prolactin signaling pathway" EXACT [GOC:TermGenie] synonym: "up regulation of prolactin-mediated signaling pathway" EXACT [GOC:TermGenie] synonym: "up-regulation of PRL signaling pathway" EXACT [GOC:TermGenie] synonym: "up-regulation of prolactin signaling pathway" EXACT [GOC:TermGenie] synonym: "up-regulation of prolactin-mediated signaling pathway" EXACT [GOC:TermGenie] synonym: "upregulation of PRL signaling pathway" EXACT [GOC:TermGenie] synonym: "upregulation of prolactin signaling pathway" EXACT [GOC:TermGenie] synonym: "upregulation of prolactin-mediated signaling pathway" EXACT [GOC:TermGenie] is_a: GO:0001961 ! positive regulation of cytokine-mediated signaling pathway is_a: GO:1902211 ! regulation of prolactin signaling pathway intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0038161 ! positively regulates prolactin signaling pathway relationship: RO:0002213 GO:0038161 ! positively regulates prolactin signaling pathway property_value: RO:0002161 NCBITaxon:4751 creation_date: 2013-06-12T10:10:18Z [Term] id: GO:1902217 name: erythrocyte apoptotic process namespace: biological_process def: "Any apoptotic process in an erythrocyte." [GOC:BHF, GOC:mtg_apoptosis, GOC:rl, GOC:TermGenie, PMID:14569084] synonym: "erythrocyte apoptosis" NARROW [GOC:TermGenie] synonym: "RBC apoptosis" NARROW [GOC:TermGenie] synonym: "RBC apoptotic process" EXACT [GOC:TermGenie] synonym: "red blood cell apoptosis" NARROW [GOC:TermGenie] synonym: "red blood cell apoptotic process" EXACT [GOC:TermGenie] is_a: GO:0033028 ! myeloid cell apoptotic process intersection_of: GO:0006915 ! apoptotic process intersection_of: BFO:0000066 CL:0000232 ! occurs in erythrocyte relationship: BFO:0000066 CL:0000232 ! occurs in erythrocyte property_value: RO:0002161 NCBITaxon:4751 creation_date: 2013-06-13T10:02:29Z [Term] id: GO:1902250 name: regulation of erythrocyte apoptotic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of erythrocyte apoptotic process." [GOC:BHF, GOC:mtg_apoptosis, GOC:rl, GOC:TermGenie, PMID:14569084] synonym: "regulation of erythrocyte apoptosis" NARROW [GOC:TermGenie] synonym: "regulation of RBC apoptosis" NARROW [GOC:TermGenie] synonym: "regulation of RBC apoptotic process" EXACT [GOC:TermGenie] synonym: "regulation of red blood cell apoptosis" NARROW [GOC:TermGenie] synonym: "regulation of red blood cell apoptotic process" EXACT [GOC:TermGenie] is_a: GO:0033032 ! regulation of myeloid cell apoptotic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:1902217 ! regulates erythrocyte apoptotic process relationship: RO:0002211 GO:1902217 ! regulates erythrocyte apoptotic process property_value: RO:0002161 NCBITaxon:4751 creation_date: 2013-06-20T19:30:53Z [Term] id: GO:1902251 name: negative regulation of erythrocyte apoptotic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of erythrocyte apoptotic process." [GOC:BHF, GOC:mtg_apoptosis, GOC:rl, GOC:TermGenie, PMID:14569084] synonym: "down regulation of erythrocyte apoptosis" NARROW [GOC:TermGenie] synonym: "down regulation of erythrocyte apoptotic process" EXACT [GOC:TermGenie] synonym: "down regulation of RBC apoptosis" NARROW [GOC:TermGenie] synonym: "down regulation of RBC apoptotic process" EXACT [GOC:TermGenie] synonym: "down regulation of red blood cell apoptosis" NARROW [GOC:TermGenie] synonym: "down regulation of red blood cell apoptotic process" EXACT [GOC:TermGenie] synonym: "down-regulation of erythrocyte apoptosis" NARROW [GOC:TermGenie] synonym: "down-regulation of erythrocyte apoptotic process" EXACT [GOC:TermGenie] synonym: "down-regulation of RBC apoptosis" NARROW [GOC:TermGenie] synonym: "down-regulation of RBC apoptotic process" EXACT [GOC:TermGenie] synonym: "down-regulation of red blood cell apoptosis" NARROW [GOC:TermGenie] synonym: "down-regulation of red blood cell apoptotic process" EXACT [GOC:TermGenie] synonym: "downregulation of erythrocyte apoptosis" NARROW [GOC:TermGenie] synonym: "downregulation of erythrocyte apoptotic process" EXACT [GOC:TermGenie] synonym: "downregulation of RBC apoptosis" NARROW [GOC:TermGenie] synonym: "downregulation of RBC apoptotic process" EXACT [GOC:TermGenie] synonym: "downregulation of red blood cell apoptosis" NARROW [GOC:TermGenie] synonym: "downregulation of red blood cell apoptotic process" EXACT [GOC:TermGenie] synonym: "inhibition of erythrocyte apoptosis" NARROW [GOC:TermGenie] synonym: "inhibition of erythrocyte apoptotic process" NARROW [GOC:TermGenie] synonym: "inhibition of RBC apoptosis" NARROW [GOC:TermGenie] synonym: "inhibition of RBC apoptotic process" NARROW [GOC:TermGenie] synonym: "inhibition of red blood cell apoptosis" NARROW [GOC:TermGenie] synonym: "inhibition of red blood cell apoptotic process" NARROW [GOC:TermGenie] synonym: "negative regulation of erythrocyte apoptosis" NARROW [GOC:TermGenie] synonym: "negative regulation of RBC apoptosis" NARROW [GOC:TermGenie] synonym: "negative regulation of RBC apoptotic process" EXACT [GOC:TermGenie] synonym: "negative regulation of red blood cell apoptosis" NARROW [GOC:TermGenie] synonym: "negative regulation of red blood cell apoptotic process" EXACT [GOC:TermGenie] is_a: GO:0033033 ! negative regulation of myeloid cell apoptotic process is_a: GO:1902250 ! regulation of erythrocyte apoptotic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:1902217 ! negatively regulates erythrocyte apoptotic process relationship: RO:0002212 GO:1902217 ! negatively regulates erythrocyte apoptotic process property_value: RO:0002161 NCBITaxon:4751 creation_date: 2013-06-20T19:30:59Z [Term] id: GO:1902252 name: positive regulation of erythrocyte apoptotic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of erythrocyte apoptotic process." [GOC:BHF, GOC:mtg_apoptosis, GOC:rl, GOC:TermGenie, PMID:14569084] synonym: "activation of erythrocyte apoptosis" NARROW [GOC:TermGenie] synonym: "activation of erythrocyte apoptotic process" NARROW [GOC:TermGenie] synonym: "activation of RBC apoptosis" NARROW [GOC:TermGenie] synonym: "activation of RBC apoptotic process" NARROW [GOC:TermGenie] synonym: "activation of red blood cell apoptosis" NARROW [GOC:TermGenie] synonym: "activation of red blood cell apoptotic process" NARROW [GOC:TermGenie] synonym: "positive regulation of erythrocyte apoptosis" NARROW [GOC:TermGenie] synonym: "positive regulation of RBC apoptosis" NARROW [GOC:TermGenie] synonym: "positive regulation of RBC apoptotic process" EXACT [GOC:TermGenie] synonym: "positive regulation of red blood cell apoptosis" NARROW [GOC:TermGenie] synonym: "positive regulation of red blood cell apoptotic process" EXACT [GOC:TermGenie] synonym: "up regulation of erythrocyte apoptosis" NARROW [GOC:TermGenie] synonym: "up regulation of erythrocyte apoptotic process" EXACT [GOC:TermGenie] synonym: "up regulation of RBC apoptosis" NARROW [GOC:TermGenie] synonym: "up regulation of RBC apoptotic process" EXACT [GOC:TermGenie] synonym: "up regulation of red blood cell apoptosis" NARROW [GOC:TermGenie] synonym: "up regulation of red blood cell apoptotic process" EXACT [GOC:TermGenie] synonym: "up-regulation of erythrocyte apoptosis" NARROW [GOC:TermGenie] synonym: "up-regulation of erythrocyte apoptotic process" EXACT [GOC:TermGenie] synonym: "up-regulation of RBC apoptosis" NARROW [GOC:TermGenie] synonym: "up-regulation of RBC apoptotic process" EXACT [GOC:TermGenie] synonym: "up-regulation of red blood cell apoptosis" NARROW [GOC:TermGenie] synonym: "up-regulation of red blood cell apoptotic process" EXACT [GOC:TermGenie] synonym: "upregulation of erythrocyte apoptosis" NARROW [GOC:TermGenie] synonym: "upregulation of erythrocyte apoptotic process" EXACT [GOC:TermGenie] synonym: "upregulation of RBC apoptosis" NARROW [GOC:TermGenie] synonym: "upregulation of RBC apoptotic process" EXACT [GOC:TermGenie] synonym: "upregulation of red blood cell apoptosis" NARROW [GOC:TermGenie] synonym: "upregulation of red blood cell apoptotic process" EXACT [GOC:TermGenie] is_a: GO:0033034 ! positive regulation of myeloid cell apoptotic process is_a: GO:1902250 ! regulation of erythrocyte apoptotic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:1902217 ! positively regulates erythrocyte apoptotic process relationship: RO:0002213 GO:1902217 ! positively regulates erythrocyte apoptotic process property_value: RO:0002161 NCBITaxon:4751 creation_date: 2013-06-20T19:31:04Z [Term] id: GO:1902256 name: regulation of apoptotic process involved in outflow tract morphogenesis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of apoptotic process involved in outflow tract morphogenesis." [GOC:dph, GOC:mtg_apoptosis, GOC:TermGenie, PMID:16839542] synonym: "regulation of apoptosis involved in outflow tract morphogenesis" NARROW [GOC:TermGenie] is_a: GO:1902337 ! regulation of apoptotic process involved in morphogenesis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0003275 ! regulates apoptotic process involved in outflow tract morphogenesis relationship: RO:0002211 GO:0003275 ! regulates apoptotic process involved in outflow tract morphogenesis creation_date: 2013-06-24T19:12:24Z [Term] id: GO:1902257 name: negative regulation of apoptotic process involved in outflow tract morphogenesis namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of apoptotic process involved in outflow tract morphogenesis." [GOC:dph, GOC:mtg_apoptosis, GOC:TermGenie, PMID:16839542] synonym: "down regulation of apoptosis involved in outflow tract morphogenesis" NARROW [GOC:TermGenie] synonym: "down regulation of apoptotic process involved in outflow tract morphogenesis" EXACT [GOC:TermGenie] synonym: "down-regulation of apoptosis involved in outflow tract morphogenesis" NARROW [GOC:TermGenie] synonym: "down-regulation of apoptotic process involved in outflow tract morphogenesis" EXACT [GOC:TermGenie] synonym: "downregulation of apoptosis involved in outflow tract morphogenesis" NARROW [GOC:TermGenie] synonym: "downregulation of apoptotic process involved in outflow tract morphogenesis" EXACT [GOC:TermGenie] synonym: "inhibition of apoptosis involved in outflow tract morphogenesis" NARROW [GOC:TermGenie] synonym: "inhibition of apoptotic process involved in outflow tract morphogenesis" NARROW [GOC:TermGenie] synonym: "negative regulation of apoptosis involved in outflow tract morphogenesis" NARROW [GOC:TermGenie] is_a: GO:1902256 ! regulation of apoptotic process involved in outflow tract morphogenesis is_a: GO:1902338 ! negative regulation of apoptotic process involved in morphogenesis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0003275 ! negatively regulates apoptotic process involved in outflow tract morphogenesis relationship: RO:0002212 GO:0003275 ! negatively regulates apoptotic process involved in outflow tract morphogenesis creation_date: 2013-06-24T19:12:30Z [Term] id: GO:1902258 name: positive regulation of apoptotic process involved in outflow tract morphogenesis namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of apoptotic process involved in outflow tract morphogenesis." [GOC:dph, GOC:mtg_apoptosis, GOC:TermGenie, PMID:16839542] synonym: "activation of apoptosis involved in outflow tract morphogenesis" NARROW [GOC:TermGenie] synonym: "activation of apoptotic process involved in outflow tract morphogenesis" NARROW [GOC:TermGenie] synonym: "positive regulation of apoptosis involved in outflow tract morphogenesis" NARROW [GOC:TermGenie] synonym: "up regulation of apoptosis involved in outflow tract morphogenesis" NARROW [GOC:TermGenie] synonym: "up regulation of apoptotic process involved in outflow tract morphogenesis" EXACT [GOC:TermGenie] synonym: "up-regulation of apoptosis involved in outflow tract morphogenesis" NARROW [GOC:TermGenie] synonym: "up-regulation of apoptotic process involved in outflow tract morphogenesis" EXACT [GOC:TermGenie] synonym: "upregulation of apoptosis involved in outflow tract morphogenesis" NARROW [GOC:TermGenie] synonym: "upregulation of apoptotic process involved in outflow tract morphogenesis" EXACT [GOC:TermGenie] is_a: GO:1902256 ! regulation of apoptotic process involved in outflow tract morphogenesis is_a: GO:1902339 ! positive regulation of apoptotic process involved in morphogenesis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0003275 ! positively regulates apoptotic process involved in outflow tract morphogenesis relationship: RO:0002213 GO:0003275 ! positively regulates apoptotic process involved in outflow tract morphogenesis creation_date: 2013-06-24T19:12:42Z [Term] id: GO:1902262 name: apoptotic process involved in blood vessel morphogenesis namespace: biological_process def: "Any apoptotic process that is involved in blood vessel morphogenesis." [GOC:dph, GOC:mtg_apoptosis, GOC:TermGenie, PMID:16163358] synonym: "apoptosis involved in patterning of blood vessels" NARROW [GOC:TermGenie] synonym: "apoptotic cell death involved in patterning of blood vessels" EXACT [GOC:TermGenie] synonym: "apoptotic program involved in patterning of blood vessels" NARROW [GOC:TermGenie] synonym: "apoptotic programmed cell death involved in patterning of blood vessels" EXACT [GOC:TermGenie] synonym: "programmed cell death by apoptosis involved in patterning of blood vessels" EXACT [GOC:TermGenie] synonym: "signaling (initiator) caspase activity involved in patterning of blood vessels" RELATED [GOC:TermGenie] synonym: "type I programmed cell death involved in patterning of blood vessels" NARROW [GOC:TermGenie] is_a: GO:0060561 ! apoptotic process involved in morphogenesis intersection_of: GO:0006915 ! apoptotic process intersection_of: BFO:0000050 GO:0048514 ! part of blood vessel morphogenesis relationship: BFO:0000050 GO:0048514 ! part of blood vessel morphogenesis creation_date: 2013-06-25T16:16:00Z [Term] id: GO:1902275 name: regulation of chromatin organization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of chromatin organization." [GO_REF:0000058, GOC:bf, GOC:TermGenie, GOC:vw, PMID:18314879] synonym: "regulation of chromatin assembly or disassembly" RELATED [] synonym: "regulation of chromatin assembly/disassembly" RELATED [] synonym: "regulation of chromatin modification" RELATED [] synonym: "regulation of chromatin organisation" EXACT [GOC:TermGenie] synonym: "regulation of establishment or maintenance of chromatin architecture" EXACT [GOC:TermGenie] is_a: GO:0051128 ! regulation of cellular component organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0006325 ! regulates chromatin organization relationship: RO:0002211 GO:0006325 ! regulates chromatin organization creation_date: 2013-07-01T13:21:52Z [Term] id: GO:1902282 name: voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization namespace: molecular_function def: "Enables the transmembrane transfer of a potassium ion by a voltage-gated channel through the plasma membrane of a ventricular cardiomyocyte contributing to the repolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:rl, GOC:TermGenie, PMID:8528244] synonym: "voltage gated potassium channel activity involved in ventricular cardiac muscle cell action potential" NARROW [GOC:TermGenie] synonym: "voltage-dependent potassium channel activity involved in ventricular cardiac muscle cell action potential" EXACT [GOC:TermGenie] synonym: "voltage-gated potassium ion channel activity involved in ventricular cardiac muscle cell action potential" EXACT [GOC:TermGenie] synonym: "voltage-sensitive potassium channel involved in ventricular cardiac muscle cell action potential" EXACT [GOC:TermGenie] is_a: GO:0086008 ! voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization intersection_of: GO:0022832 ! voltage-gated channel activity intersection_of: BFO:0000050 GO:0098915 ! part of membrane repolarization during ventricular cardiac muscle cell action potential intersection_of: RO:0004009 CHEBI:29103 ! has primary input relationship: BFO:0000050 GO:0098915 ! part of membrane repolarization during ventricular cardiac muscle cell action potential creation_date: 2013-07-05T20:12:22Z [Term] id: GO:1902305 name: regulation of sodium ion transmembrane transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of sodium ion transmembrane transport." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:rl, GOC:TermGenie, PMID:18591664] synonym: "regulation of sodium ion membrane transport" EXACT [GOC:TermGenie] is_a: GO:0002028 ! regulation of sodium ion transport is_a: GO:1904062 ! regulation of monoatomic cation transmembrane transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0035725 ! regulates sodium ion transmembrane transport relationship: RO:0002211 GO:0035725 ! regulates sodium ion transmembrane transport creation_date: 2013-07-18T13:33:53Z [Term] id: GO:1902306 name: negative regulation of sodium ion transmembrane transport namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of sodium ion transmembrane transport." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:rl, GOC:TermGenie, PMID:18591664] synonym: "down regulation of sodium ion membrane transport" EXACT [GOC:TermGenie] synonym: "down regulation of sodium ion transmembrane transport" EXACT [GOC:TermGenie] synonym: "down-regulation of sodium ion membrane transport" EXACT [GOC:TermGenie] synonym: "down-regulation of sodium ion transmembrane transport" EXACT [GOC:TermGenie] synonym: "downregulation of sodium ion membrane transport" EXACT [GOC:TermGenie] synonym: "downregulation of sodium ion transmembrane transport" EXACT [GOC:TermGenie] synonym: "inhibition of sodium ion membrane transport" NARROW [GOC:TermGenie] synonym: "inhibition of sodium ion transmembrane transport" NARROW [GOC:TermGenie] synonym: "negative regulation of sodium ion membrane transport" EXACT [GOC:TermGenie] is_a: GO:0010766 ! negative regulation of sodium ion transport is_a: GO:1902305 ! regulation of sodium ion transmembrane transport is_a: GO:1904063 ! negative regulation of cation transmembrane transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0035725 ! negatively regulates sodium ion transmembrane transport relationship: RO:0002212 GO:0035725 ! negatively regulates sodium ion transmembrane transport creation_date: 2013-07-18T13:34:01Z [Term] id: GO:1902307 name: positive regulation of sodium ion transmembrane transport namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of sodium ion transmembrane transport." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:rl, GOC:TermGenie, PMID:18591664] synonym: "activation of sodium ion membrane transport" NARROW [GOC:TermGenie] synonym: "activation of sodium ion transmembrane transport" NARROW [GOC:TermGenie] synonym: "positive regulation of sodium ion membrane transport" EXACT [GOC:TermGenie] synonym: "up regulation of sodium ion membrane transport" EXACT [GOC:TermGenie] synonym: "up regulation of sodium ion transmembrane transport" EXACT [GOC:TermGenie] synonym: "up-regulation of sodium ion membrane transport" EXACT [GOC:TermGenie] synonym: "up-regulation of sodium ion transmembrane transport" EXACT [GOC:TermGenie] synonym: "upregulation of sodium ion membrane transport" EXACT [GOC:TermGenie] synonym: "upregulation of sodium ion transmembrane transport" EXACT [GOC:TermGenie] is_a: GO:0010765 ! positive regulation of sodium ion transport is_a: GO:1902305 ! regulation of sodium ion transmembrane transport is_a: GO:1904064 ! positive regulation of cation transmembrane transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0035725 ! positively regulates sodium ion transmembrane transport relationship: RO:0002213 GO:0035725 ! positively regulates sodium ion transmembrane transport creation_date: 2013-07-18T13:34:18Z [Term] id: GO:1902337 name: regulation of apoptotic process involved in morphogenesis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of apoptotic process involved in morphogenesis." [GOC:sart, GOC:TermGenie, PMID:12202035] synonym: "regulation of apoptosis involved in development" RELATED [GOC:TermGenie] synonym: "regulation of apoptosis involved in morphogenesis" NARROW [GOC:TermGenie] synonym: "regulation of morphogenetic apoptosis" RELATED [GOC:TermGenie] is_a: GO:1904748 ! regulation of apoptotic process involved in development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0060561 ! regulates apoptotic process involved in morphogenesis relationship: RO:0002211 GO:0060561 ! regulates apoptotic process involved in morphogenesis property_value: RO:0002161 NCBITaxon:4896 creation_date: 2013-07-29T15:03:16Z [Term] id: GO:1902338 name: negative regulation of apoptotic process involved in morphogenesis namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of apoptotic process involved in morphogenesis." [GOC:sart, GOC:TermGenie, PMID:12202035] synonym: "down regulation of apoptosis involved in development" RELATED [GOC:TermGenie] synonym: "down regulation of apoptosis involved in morphogenesis" NARROW [GOC:TermGenie] synonym: "down regulation of apoptotic process involved in morphogenesis" EXACT [GOC:TermGenie] synonym: "down regulation of morphogenetic apoptosis" RELATED [GOC:TermGenie] synonym: "down-regulation of apoptosis involved in development" RELATED [GOC:TermGenie] synonym: "down-regulation of apoptosis involved in morphogenesis" NARROW [GOC:TermGenie] synonym: "down-regulation of apoptotic process involved in morphogenesis" EXACT [GOC:TermGenie] synonym: "down-regulation of morphogenetic apoptosis" RELATED [GOC:TermGenie] synonym: "downregulation of apoptosis involved in development" RELATED [GOC:TermGenie] synonym: "downregulation of apoptosis involved in morphogenesis" NARROW [GOC:TermGenie] synonym: "downregulation of apoptotic process involved in morphogenesis" EXACT [GOC:TermGenie] synonym: "downregulation of morphogenetic apoptosis" RELATED [GOC:TermGenie] synonym: "inhibition of apoptosis involved in development" RELATED [GOC:TermGenie] synonym: "inhibition of apoptosis involved in morphogenesis" NARROW [GOC:TermGenie] synonym: "inhibition of apoptotic process involved in morphogenesis" NARROW [GOC:TermGenie] synonym: "inhibition of morphogenetic apoptosis" RELATED [GOC:TermGenie] synonym: "negative regulation of apoptosis involved in development" RELATED [GOC:TermGenie] synonym: "negative regulation of apoptosis involved in morphogenesis" NARROW [GOC:TermGenie] synonym: "negative regulation of morphogenetic apoptosis" RELATED [GOC:TermGenie] is_a: GO:1902337 ! regulation of apoptotic process involved in morphogenesis is_a: GO:1904746 ! negative regulation of apoptotic process involved in development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0060561 ! negatively regulates apoptotic process involved in morphogenesis relationship: RO:0002212 GO:0060561 ! negatively regulates apoptotic process involved in morphogenesis property_value: RO:0002161 NCBITaxon:4896 creation_date: 2013-07-29T15:03:25Z [Term] id: GO:1902339 name: positive regulation of apoptotic process involved in morphogenesis namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of apoptotic process involved in morphogenesis." [GOC:sart, GOC:TermGenie, PMID:12202035] synonym: "activation of apoptosis involved in development" RELATED [GOC:TermGenie] synonym: "activation of apoptosis involved in morphogenesis" NARROW [GOC:TermGenie] synonym: "activation of apoptotic process involved in morphogenesis" NARROW [GOC:TermGenie] synonym: "activation of morphogenetic apoptosis" RELATED [GOC:TermGenie] synonym: "positive regulation of apoptosis involved in development" RELATED [GOC:TermGenie] synonym: "positive regulation of apoptosis involved in morphogenesis" NARROW [GOC:TermGenie] synonym: "positive regulation of morphogenetic apoptosis" RELATED [GOC:TermGenie] synonym: "up regulation of apoptosis involved in development" RELATED [GOC:TermGenie] synonym: "up regulation of apoptosis involved in morphogenesis" NARROW [GOC:TermGenie] synonym: "up regulation of apoptotic process involved in morphogenesis" EXACT [GOC:TermGenie] synonym: "up regulation of morphogenetic apoptosis" RELATED [GOC:TermGenie] synonym: "up-regulation of apoptosis involved in development" RELATED [GOC:TermGenie] synonym: "up-regulation of apoptosis involved in morphogenesis" NARROW [GOC:TermGenie] synonym: "up-regulation of apoptotic process involved in morphogenesis" EXACT [GOC:TermGenie] synonym: "up-regulation of morphogenetic apoptosis" RELATED [GOC:TermGenie] synonym: "upregulation of apoptosis involved in development" RELATED [GOC:TermGenie] synonym: "upregulation of apoptosis involved in morphogenesis" NARROW [GOC:TermGenie] synonym: "upregulation of apoptotic process involved in morphogenesis" EXACT [GOC:TermGenie] synonym: "upregulation of morphogenetic apoptosis" RELATED [GOC:TermGenie] is_a: GO:1902337 ! regulation of apoptotic process involved in morphogenesis is_a: GO:1904747 ! positive regulation of apoptotic process involved in development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0060561 ! positively regulates apoptotic process involved in morphogenesis relationship: RO:0002213 GO:0060561 ! positively regulates apoptotic process involved in morphogenesis property_value: RO:0002161 NCBITaxon:4896 creation_date: 2013-07-29T15:03:33Z [Term] id: GO:1902340 name: negative regulation of chromosome condensation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of chromosome condensation." [GOC:TermGenie, PMID:23219725] synonym: "down regulation of chromosome condensation" EXACT [GOC:TermGenie] synonym: "down regulation of eukaryotic chromosome condensation" EXACT [GOC:TermGenie] synonym: "down regulation of nuclear chromosome condensation" EXACT [GOC:TermGenie] synonym: "down-regulation of chromosome condensation" EXACT [GOC:TermGenie] synonym: "down-regulation of eukaryotic chromosome condensation" EXACT [GOC:TermGenie] synonym: "down-regulation of nuclear chromosome condensation" EXACT [GOC:TermGenie] synonym: "downregulation of chromosome condensation" EXACT [GOC:TermGenie] synonym: "downregulation of eukaryotic chromosome condensation" EXACT [GOC:TermGenie] synonym: "downregulation of nuclear chromosome condensation" EXACT [GOC:TermGenie] synonym: "inhibition of chromosome condensation" NARROW [GOC:TermGenie] synonym: "inhibition of eukaryotic chromosome condensation" NARROW [GOC:TermGenie] synonym: "inhibition of nuclear chromosome condensation" NARROW [GOC:TermGenie] synonym: "negative regulation of eukaryotic chromosome condensation" EXACT [GOC:TermGenie] synonym: "negative regulation of nuclear chromosome condensation" EXACT [GOC:TermGenie] is_a: GO:0060623 ! regulation of chromosome condensation is_a: GO:2001251 ! negative regulation of chromosome organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0030261 ! negatively regulates chromosome condensation relationship: RO:0002212 GO:0030261 ! negatively regulates chromosome condensation creation_date: 2013-07-29T20:54:14Z [Term] id: GO:1902362 name: melanocyte apoptotic process namespace: biological_process def: "Any apoptotic process in a melanocyte, the main structural component of the epidermis." [GOC:ic, GOC:TermGenie, PMID:20530876] synonym: "melanocyte apoptosis" NARROW [GOC:TermGenie] synonym: "melanophore apoptosis" NARROW [GOC:TermGenie] synonym: "melanophore apoptotic process" NARROW [GOC:TermGenie] is_a: GO:0006915 ! apoptotic process intersection_of: GO:0006915 ! apoptotic process intersection_of: BFO:0000066 CL:0000148 ! occurs in melanocyte relationship: BFO:0000066 CL:0000148 ! occurs in melanocyte property_value: RO:0002161 NCBITaxon:4896 creation_date: 2013-08-15T16:35:45Z [Term] id: GO:1902369 name: negative regulation of RNA catabolic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of RNA catabolic process." [GOC:bf, GOC:TermGenie, PMID:16640457] synonym: "down regulation of RNA breakdown" EXACT [GOC:TermGenie] synonym: "down regulation of RNA catabolic process" EXACT [GOC:TermGenie] synonym: "down regulation of RNA catabolism" EXACT [GOC:TermGenie] synonym: "down regulation of RNA degradation" EXACT [GOC:TermGenie] synonym: "down-regulation of RNA breakdown" EXACT [GOC:TermGenie] synonym: "down-regulation of RNA catabolic process" EXACT [GOC:TermGenie] synonym: "down-regulation of RNA catabolism" EXACT [GOC:TermGenie] synonym: "down-regulation of RNA degradation" EXACT [GOC:TermGenie] synonym: "downregulation of RNA breakdown" EXACT [GOC:TermGenie] synonym: "downregulation of RNA catabolic process" EXACT [GOC:TermGenie] synonym: "downregulation of RNA catabolism" EXACT [GOC:TermGenie] synonym: "downregulation of RNA degradation" EXACT [GOC:TermGenie] synonym: "inhibition of RNA breakdown" NARROW [GOC:TermGenie] synonym: "inhibition of RNA catabolic process" NARROW [GOC:TermGenie] synonym: "inhibition of RNA catabolism" NARROW [GOC:TermGenie] synonym: "inhibition of RNA degradation" NARROW [GOC:TermGenie] synonym: "negative regulation of RNA breakdown" EXACT [GOC:TermGenie] synonym: "negative regulation of RNA catabolism" EXACT [GOC:TermGenie] synonym: "negative regulation of RNA degradation" EXACT [GOC:TermGenie] is_a: GO:0009895 ! negative regulation of catabolic process is_a: GO:0051253 ! negative regulation of RNA metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0006401 ! negatively regulates RNA catabolic process relationship: RO:0002212 GO:0006401 ! negatively regulates RNA catabolic process creation_date: 2013-08-22T14:59:39Z [Term] id: GO:1902396 name: protein localization to bicellular tight junction namespace: biological_process def: "A process in which a protein is transported to, or maintained in, a location within a bicellular tight junction." [GOC:TermGenie, PMID:18332111] synonym: "protein localisation in tight junction" EXACT [GOC:TermGenie] synonym: "protein localisation to tight junction" EXACT [GOC:TermGenie] synonym: "protein localization in tight junction" EXACT [GOC:TermGenie] is_a: GO:0150105 ! protein localization to cell-cell junction intersection_of: GO:0008104 ! intracellular protein localization intersection_of: RO:0002339 GO:0005923 ! has target end location bicellular tight junction relationship: RO:0002339 GO:0005923 ! has target end location bicellular tight junction creation_date: 2013-09-11T21:43:13Z [Term] id: GO:1902414 name: protein localization to cell junction namespace: biological_process def: "A process in which a protein is transported to, or maintained in, a location within a cell junction." [GOC:TermGenie, PMID:18332111] synonym: "protein localisation in cell junction" EXACT [GOC:TermGenie] synonym: "protein localisation to cell junction" EXACT [GOC:TermGenie] synonym: "protein localization in cell junction" EXACT [GOC:TermGenie] is_a: GO:0008104 ! intracellular protein localization intersection_of: GO:0008104 ! intracellular protein localization intersection_of: RO:0002339 GO:0030054 ! has target end location cell junction relationship: RO:0002339 GO:0030054 ! has target end location cell junction creation_date: 2013-09-13T16:55:57Z [Term] id: GO:1902427 name: regulation of water channel activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of water channel activity." [GOC:nhn, GOC:TermGenie, PMID:22095752] subset: gocheck_obsoletion_candidate synonym: "regulation of aquaporin" NARROW [GOC:TermGenie] synonym: "regulation of aquaporin permeability" NARROW [PMID:22095752] is_a: GO:0022898 ! regulation of transmembrane transporter activity intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0015250 ! regulates water channel activity relationship: RO:0002211 GO:0015250 ! regulates water channel activity creation_date: 2013-09-23T12:56:31Z [Term] id: GO:1902455 name: negative regulation of stem cell population maintenance namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of stem cell population maintenance." [GOC:hjd, GOC:TermGenie, PMID:22969033] synonym: "down regulation of maintenance of pluripotency" RELATED [GOC:TermGenie] synonym: "down regulation of stem cell maintenance" EXACT [GOC:TermGenie] synonym: "down-regulation of maintenance of pluripotency" RELATED [GOC:TermGenie] synonym: "down-regulation of stem cell maintenance" EXACT [GOC:TermGenie] synonym: "downregulation of maintenance of pluripotency" RELATED [GOC:TermGenie] synonym: "downregulation of stem cell maintenance" EXACT [GOC:TermGenie] synonym: "inhibition of maintenance of pluripotency" RELATED [GOC:TermGenie] synonym: "inhibition of stem cell maintenance" NARROW [GOC:TermGenie] synonym: "negative regulation of maintenance of pluripotency" RELATED [GOC:TermGenie] is_a: GO:0051093 ! negative regulation of developmental process is_a: GO:0051241 ! negative regulation of multicellular organismal process is_a: GO:2000036 ! regulation of stem cell population maintenance intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0019827 ! negatively regulates stem cell population maintenance relationship: RO:0002212 GO:0019827 ! negatively regulates stem cell population maintenance property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4751 creation_date: 2013-10-16T22:19:17Z [Term] id: GO:1902459 name: positive regulation of stem cell population maintenance namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of stem cell population maintenance." [GOC:hjd, GOC:TermGenie, PMID:22969033] synonym: "activation of maintenance of pluripotency" RELATED [GOC:TermGenie] synonym: "activation of stem cell maintenance" NARROW [GOC:TermGenie] synonym: "positive regulation of maintenance of pluripotency" RELATED [GOC:TermGenie] synonym: "up regulation of maintenance of pluripotency" RELATED [GOC:TermGenie] synonym: "up regulation of stem cell maintenance" EXACT [GOC:TermGenie] synonym: "up-regulation of maintenance of pluripotency" RELATED [GOC:TermGenie] synonym: "up-regulation of stem cell maintenance" EXACT [GOC:TermGenie] synonym: "upregulation of maintenance of pluripotency" RELATED [GOC:TermGenie] synonym: "upregulation of stem cell maintenance" EXACT [GOC:TermGenie] is_a: GO:0051094 ! positive regulation of developmental process is_a: GO:0051240 ! positive regulation of multicellular organismal process is_a: GO:2000036 ! regulation of stem cell population maintenance intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0019827 ! positively regulates stem cell population maintenance relationship: RO:0002213 GO:0019827 ! positively regulates stem cell population maintenance property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4751 creation_date: 2013-10-16T22:27:47Z [Term] id: GO:1902463 name: protein localization to cell leading edge namespace: biological_process def: "A process in which a protein is transported to, or maintained in, a location within a cell leading edge." [GOC:lb, GOC:TermGenie, PMID:21543326] synonym: "protein localisation in cell leading edge" EXACT [GOC:TermGenie] synonym: "protein localisation to cell leading edge" EXACT [GOC:TermGenie] synonym: "protein localization in cell leading edge" EXACT [GOC:TermGenie] is_a: GO:0008104 ! intracellular protein localization intersection_of: GO:0008104 ! intracellular protein localization intersection_of: RO:0002339 GO:0031252 ! has target end location cell leading edge relationship: RO:0002339 GO:0031252 ! has target end location cell leading edge creation_date: 2013-10-22T12:36:07Z [Term] id: GO:1902473 name: regulation of protein localization to synapse namespace: biological_process def: "Any process that modulates the frequency, rate or extent of protein localization to synapse." [GOC:kmv, GOC:TermGenie, PMID:22588719] synonym: "regulation of protein localisation to synapse" EXACT [GOC:TermGenie] is_a: GO:0032880 ! regulation of protein localization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0035418 ! regulates protein localization to synapse relationship: RO:0002211 GO:0035418 ! regulates protein localization to synapse creation_date: 2013-10-25T15:09:09Z [Term] id: GO:1902474 name: positive regulation of protein localization to synapse namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of protein localization to synapse." [GOC:kmv, GOC:TermGenie, PMID:22588719] synonym: "activation of protein localisation to synapse" NARROW [GOC:TermGenie] synonym: "activation of protein localization to synapse" NARROW [GOC:TermGenie] synonym: "positive regulation of protein localisation to synapse" EXACT [GOC:TermGenie] synonym: "up regulation of protein localisation to synapse" EXACT [GOC:TermGenie] synonym: "up regulation of protein localization to synapse" EXACT [GOC:TermGenie] synonym: "up-regulation of protein localisation to synapse" EXACT [GOC:TermGenie] synonym: "up-regulation of protein localization to synapse" EXACT [GOC:TermGenie] synonym: "upregulation of protein localisation to synapse" EXACT [GOC:TermGenie] synonym: "upregulation of protein localization to synapse" EXACT [GOC:TermGenie] is_a: GO:1902473 ! regulation of protein localization to synapse is_a: GO:1903829 ! positive regulation of protein localization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0035418 ! positively regulates protein localization to synapse relationship: RO:0002213 GO:0035418 ! positively regulates protein localization to synapse creation_date: 2013-10-25T15:09:18Z [Term] id: GO:1902475 name: L-alpha-amino acid transmembrane transport namespace: biological_process def: "The directed movement of L-alpha-amino acid across a membrane by means of some agent such as a transporter or a pore." [GOC:kmv, GOC:TermGenie, PMID:14668347] is_a: GO:0003333 ! amino acid transmembrane transport is_a: GO:0015807 ! L-amino acid transport is_a: GO:1905039 ! carboxylic acid transmembrane transport intersection_of: GO:0055085 ! transmembrane transport intersection_of: RO:0004009 CHEBI:59869 ! has primary input creation_date: 2013-10-25T15:17:39Z [Term] id: GO:1902482 name: regulatory T cell apoptotic process namespace: biological_process def: "Any apoptotic process in a regulatory T cell." [GOC:nhn, GOC:TermGenie, PMID:20471291] synonym: "regulatory T cell apoptosis" NARROW [GOC:TermGenie] synonym: "regulatory T lymphocyte apoptosis" NARROW [GOC:TermGenie] synonym: "regulatory T lymphocyte apoptotic process" EXACT [GOC:TermGenie] synonym: "regulatory T-cell apoptosis" NARROW [GOC:TermGenie] synonym: "regulatory T-cell apoptotic process" EXACT [GOC:TermGenie] synonym: "regulatory T-lymphocyte apoptosis" NARROW [GOC:TermGenie] synonym: "regulatory T-lymphocyte apoptotic process" EXACT [GOC:TermGenie] is_a: GO:0070231 ! T cell apoptotic process intersection_of: GO:0006915 ! apoptotic process intersection_of: BFO:0000066 CL:0000815 ! occurs in regulatory T cell relationship: BFO:0000066 CL:0000815 ! occurs in regulatory T cell creation_date: 2013-11-04T17:18:09Z [Term] id: GO:1902484 name: Sertoli cell apoptotic process namespace: biological_process def: "Any apoptotic process in a Sertoli cell." [GOC:ic, GOC:TermGenie, PMID:17761895] synonym: "Sertoli cell apoptosis" NARROW [GOC:TermGenie] is_a: GO:1904019 ! epithelial cell apoptotic process intersection_of: GO:0006915 ! apoptotic process intersection_of: BFO:0000066 CL:0000216 ! occurs in Sertoli cell relationship: BFO:0000066 CL:0000216 ! occurs in Sertoli cell property_value: RO:0002161 NCBITaxon:4751 creation_date: 2013-11-06T11:27:34Z [Term] id: GO:1902488 name: cholangiocyte apoptotic process namespace: biological_process def: "Any apoptotic process in a cholangiocyte." [GOC:TermGenie, PMID:22961800] synonym: "cholangiocyte apoptosis" NARROW [GOC:TermGenie] synonym: "epithelial cell of bile duct apoptosis" NARROW [GOC:TermGenie] synonym: "epithelial cell of bile duct apoptotic process" EXACT [GOC:TermGenie] is_a: GO:1904019 ! epithelial cell apoptotic process intersection_of: GO:0006915 ! apoptotic process intersection_of: BFO:0000066 CL:1000488 ! occurs in cholangiocyte relationship: BFO:0000066 CL:1000488 ! occurs in cholangiocyte property_value: RO:0002161 NCBITaxon:4751 creation_date: 2013-11-12T15:30:08Z [Term] id: GO:1902489 name: hepatoblast apoptotic process namespace: biological_process def: "Any apoptotic process in a hepatoblast." [GOC:TermGenie, PMID:22412967] synonym: "hepatoblast apoptosis" NARROW [GOC:TermGenie] is_a: GO:0006915 ! apoptotic process intersection_of: GO:0006915 ! apoptotic process intersection_of: BFO:0000066 CL:0005026 ! occurs in hepatoblast relationship: BFO:0000066 CL:0005026 ! occurs in hepatoblast property_value: RO:0002161 NCBITaxon:4896 creation_date: 2013-11-12T17:02:52Z [Term] id: GO:1902490 name: regulation of sperm capacitation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of sperm capacitation." [GOC:hjd, GOC:TermGenie, PMID:22539676] synonym: "regulation of sperm activation" RELATED [GOC:TermGenie] is_a: GO:0051239 ! regulation of multicellular organismal process is_a: GO:1903429 ! regulation of cell maturation is_a: GO:2000241 ! regulation of reproductive process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0048240 ! regulates sperm capacitation relationship: RO:0002211 GO:0048240 ! regulates sperm capacitation property_value: RO:0002161 NCBITaxon:3176 property_value: RO:0002161 NCBITaxon:3378 property_value: RO:0002161 NCBITaxon:3398 property_value: RO:0002161 NCBITaxon:4751 property_value: RO:0002161 NCBITaxon:5782 creation_date: 2013-11-12T21:17:03Z [Term] id: GO:1902491 name: negative regulation of sperm capacitation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of sperm capacitation." [GOC:hjd, GOC:TermGenie, PMID:22539676] synonym: "down regulation of sperm activation" RELATED [GOC:TermGenie] synonym: "down regulation of sperm capacitation" EXACT [GOC:TermGenie] synonym: "down-regulation of sperm activation" RELATED [GOC:TermGenie] synonym: "down-regulation of sperm capacitation" EXACT [GOC:TermGenie] synonym: "downregulation of sperm activation" RELATED [GOC:TermGenie] synonym: "downregulation of sperm capacitation" EXACT [GOC:TermGenie] synonym: "inhibition of sperm activation" RELATED [GOC:TermGenie] synonym: "inhibition of sperm capacitation" NARROW [GOC:TermGenie] synonym: "negative regulation of sperm activation" RELATED [GOC:TermGenie] is_a: GO:0051241 ! negative regulation of multicellular organismal process is_a: GO:1902490 ! regulation of sperm capacitation is_a: GO:1903430 ! negative regulation of cell maturation is_a: GO:2000242 ! negative regulation of reproductive process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0048240 ! negatively regulates sperm capacitation relationship: RO:0002212 GO:0048240 ! negatively regulates sperm capacitation property_value: RO:0002161 NCBITaxon:3176 property_value: RO:0002161 NCBITaxon:3378 property_value: RO:0002161 NCBITaxon:3398 property_value: RO:0002161 NCBITaxon:4751 property_value: RO:0002161 NCBITaxon:5782 creation_date: 2013-11-12T21:17:12Z [Term] id: GO:1902492 name: positive regulation of sperm capacitation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of sperm capacitation." [GOC:hjd, GOC:TermGenie, PMID:22539676] synonym: "activation of sperm activation" RELATED [GOC:TermGenie] synonym: "activation of sperm capacitation" NARROW [GOC:TermGenie] synonym: "positive regulation of sperm activation" RELATED [GOC:TermGenie] synonym: "up regulation of sperm activation" RELATED [GOC:TermGenie] synonym: "up regulation of sperm capacitation" EXACT [GOC:TermGenie] synonym: "up-regulation of sperm activation" RELATED [GOC:TermGenie] synonym: "up-regulation of sperm capacitation" EXACT [GOC:TermGenie] synonym: "upregulation of sperm activation" RELATED [GOC:TermGenie] synonym: "upregulation of sperm capacitation" EXACT [GOC:TermGenie] is_a: GO:0051240 ! positive regulation of multicellular organismal process is_a: GO:1902490 ! regulation of sperm capacitation is_a: GO:1903431 ! positive regulation of cell maturation is_a: GO:2000243 ! positive regulation of reproductive process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0048240 ! positively regulates sperm capacitation relationship: RO:0002213 GO:0048240 ! positively regulates sperm capacitation property_value: RO:0002161 NCBITaxon:3176 property_value: RO:0002161 NCBITaxon:3378 property_value: RO:0002161 NCBITaxon:3398 property_value: RO:0002161 NCBITaxon:4751 property_value: RO:0002161 NCBITaxon:5782 creation_date: 2013-11-12T21:17:21Z [Term] id: GO:1902494 name: catalytic complex namespace: cellular_component def: "A protein complex which is capable of catalytic activity." [GOC:bhm, GOC:TermGenie, PMID:8077207] subset: goslim_metagenomics synonym: "enzyme complex" EXACT [GOC:bhm, GOC:jl] is_a: BFO:0000004 is_a: GO:0032991 ! protein-containing complex intersection_of: GO:0032991 ! protein-containing complex intersection_of: RO:0002215 GO:0003824 ! capable of catalytic activity relationship: RO:0002215 GO:0003824 ! capable of catalytic activity property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/19980" xsd:anyURI creation_date: 2013-11-13T16:18:47Z [Term] id: GO:1902495 name: transmembrane transporter complex namespace: cellular_component def: "A transmembrane protein complex which enables the transfer of a substance from one side of a membrane to the other." [GOC:bhm, GOC:TermGenie, PMID:18024586] is_a: GO:0098796 ! membrane protein complex is_a: GO:1990351 ! transporter complex intersection_of: GO:0032991 ! protein-containing complex intersection_of: RO:0002215 GO:0022857 ! capable of transmembrane transporter activity relationship: RO:0002215 GO:0022857 ! capable of transmembrane transporter activity creation_date: 2013-11-13T16:23:04Z [Term] id: GO:1902510 name: regulation of apoptotic DNA fragmentation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of apoptotic DNA fragmentation." [GOC:hjd, GOC:TermGenie, PMID:15572351, PMID:15723341] comment: DNA fragmentation in response to apoptotic signals is achieved through the activity of apoptotic nucleases (see GO:0006309 'apoptotic DNA fragmentation'). Gene products involved in compartmentalization of such nucleases and in activation or repression of their enzymatic activity should be annotated to the regulation term GO:1902510 'regulation of apoptotic DNA fragmentation' or to one of its children (see PMID:15723341). synonym: "regulation of chromatinolysis" BROAD [GOC:TermGenie] synonym: "regulation of DNA catabolic process during apoptosis" EXACT [GOC:TermGenie] synonym: "regulation of DNA catabolism during apoptosis" EXACT [GOC:TermGenie] synonym: "regulation of DNA fragmentation" BROAD [GOC:TermGenie] synonym: "regulation of DNA fragmentation involved in apoptotic nuclear change" EXACT [GOC:TermGenie] synonym: "regulation of endonucleolytic DNA catabolic process involved in apoptosis" EXACT [GOC:TermGenie] is_a: GO:1903624 ! regulation of DNA catabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0006309 ! regulates apoptotic DNA fragmentation relationship: RO:0002211 GO:0006309 ! regulates apoptotic DNA fragmentation property_value: RO:0002161 NCBITaxon:4896 creation_date: 2013-11-15T18:28:32Z [Term] id: GO:1902511 name: negative regulation of apoptotic DNA fragmentation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of apoptotic DNA fragmentation." [GOC:hjd, GOC:TermGenie, PMID:15572351] synonym: "down regulation of apoptotic DNA fragmentation" EXACT [GOC:TermGenie] synonym: "down regulation of DNA catabolic process during apoptosis" EXACT [GOC:TermGenie] synonym: "down regulation of DNA catabolism during apoptosis" EXACT [GOC:TermGenie] synonym: "down regulation of DNA fragmentation involved in apoptotic nuclear change" EXACT [GOC:TermGenie] synonym: "down regulation of endonucleolytic DNA catabolic process involved in apoptosis" EXACT [GOC:TermGenie] synonym: "down-regulation of apoptotic DNA fragmentation" EXACT [GOC:TermGenie] synonym: "down-regulation of DNA catabolic process during apoptosis" EXACT [GOC:TermGenie] synonym: "down-regulation of DNA catabolism during apoptosis" EXACT [GOC:TermGenie] synonym: "down-regulation of DNA fragmentation involved in apoptotic nuclear change" EXACT [GOC:TermGenie] synonym: "down-regulation of endonucleolytic DNA catabolic process involved in apoptosis" EXACT [GOC:TermGenie] synonym: "downregulation of apoptotic DNA fragmentation" EXACT [GOC:TermGenie] synonym: "downregulation of DNA catabolic process during apoptosis" EXACT [GOC:TermGenie] synonym: "downregulation of DNA catabolism during apoptosis" EXACT [GOC:TermGenie] synonym: "downregulation of DNA fragmentation involved in apoptotic nuclear change" EXACT [GOC:TermGenie] synonym: "downregulation of endonucleolytic DNA catabolic process involved in apoptosis" EXACT [GOC:TermGenie] synonym: "inhibition of apoptotic DNA fragmentation" NARROW [GOC:TermGenie] synonym: "inhibition of DNA catabolic process during apoptosis" NARROW [GOC:TermGenie] synonym: "inhibition of DNA catabolism during apoptosis" NARROW [GOC:TermGenie] synonym: "inhibition of DNA fragmentation involved in apoptotic nuclear change" NARROW [GOC:TermGenie] synonym: "inhibition of endonucleolytic DNA catabolic process involved in apoptosis" NARROW [GOC:TermGenie] synonym: "negative regulation of DNA catabolic process during apoptosis" EXACT [GOC:TermGenie] synonym: "negative regulation of DNA catabolism during apoptosis" EXACT [GOC:TermGenie] synonym: "negative regulation of DNA fragmentation involved in apoptotic nuclear change" EXACT [GOC:TermGenie] synonym: "negative regulation of endonucleolytic DNA catabolic process involved in apoptosis" EXACT [GOC:TermGenie] is_a: GO:1902510 ! regulation of apoptotic DNA fragmentation is_a: GO:1903625 ! negative regulation of DNA catabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0006309 ! negatively regulates apoptotic DNA fragmentation relationship: RO:0002212 GO:0006309 ! negatively regulates apoptotic DNA fragmentation property_value: RO:0002161 NCBITaxon:4896 creation_date: 2013-11-15T18:28:41Z [Term] id: GO:1902512 name: positive regulation of apoptotic DNA fragmentation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of apoptotic DNA fragmentation." [GOC:hjd, GOC:TermGenie, PMID:15572351] synonym: "activation of apoptotic DNA fragmentation" NARROW [GOC:TermGenie] synonym: "activation of DNA catabolic process during apoptosis" NARROW [GOC:TermGenie] synonym: "activation of DNA catabolism during apoptosis" NARROW [GOC:TermGenie] synonym: "activation of DNA fragmentation involved in apoptotic nuclear change" NARROW [GOC:TermGenie] synonym: "activation of endonucleolytic DNA catabolic process involved in apoptosis" NARROW [GOC:TermGenie] synonym: "positive regulation of DNA catabolic process during apoptosis" EXACT [GOC:TermGenie] synonym: "positive regulation of DNA catabolism during apoptosis" EXACT [GOC:TermGenie] synonym: "positive regulation of DNA fragmentation involved in apoptotic nuclear change" EXACT [GOC:TermGenie] synonym: "positive regulation of endonucleolytic DNA catabolic process involved in apoptosis" EXACT [GOC:TermGenie] synonym: "up regulation of apoptotic DNA fragmentation" EXACT [GOC:TermGenie] synonym: "up regulation of DNA catabolic process during apoptosis" EXACT [GOC:TermGenie] synonym: "up regulation of DNA catabolism during apoptosis" EXACT [GOC:TermGenie] synonym: "up regulation of DNA fragmentation involved in apoptotic nuclear change" EXACT [GOC:TermGenie] synonym: "up regulation of endonucleolytic DNA catabolic process involved in apoptosis" EXACT [GOC:TermGenie] synonym: "up-regulation of apoptotic DNA fragmentation" EXACT [GOC:TermGenie] synonym: "up-regulation of DNA catabolic process during apoptosis" EXACT [GOC:TermGenie] synonym: "up-regulation of DNA catabolism during apoptosis" EXACT [GOC:TermGenie] synonym: "up-regulation of DNA fragmentation involved in apoptotic nuclear change" EXACT [GOC:TermGenie] synonym: "up-regulation of endonucleolytic DNA catabolic process involved in apoptosis" EXACT [GOC:TermGenie] synonym: "upregulation of apoptotic DNA fragmentation" EXACT [GOC:TermGenie] synonym: "upregulation of DNA catabolic process during apoptosis" EXACT [GOC:TermGenie] synonym: "upregulation of DNA catabolism during apoptosis" EXACT [GOC:TermGenie] synonym: "upregulation of DNA fragmentation involved in apoptotic nuclear change" EXACT [GOC:TermGenie] synonym: "upregulation of endonucleolytic DNA catabolic process involved in apoptosis" EXACT [GOC:TermGenie] is_a: GO:1902510 ! regulation of apoptotic DNA fragmentation is_a: GO:1903626 ! positive regulation of DNA catabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0006309 ! positively regulates apoptotic DNA fragmentation relationship: RO:0002213 GO:0006309 ! positively regulates apoptotic DNA fragmentation property_value: RO:0002161 NCBITaxon:4896 creation_date: 2013-11-15T18:28:50Z [Term] id: GO:1902513 name: regulation of organelle transport along microtubule namespace: biological_process def: "Any process that modulates the frequency, rate or extent of organelle transport along microtubule." [GOC:dph, GOC:TermGenie, PMID:21147087] synonym: "regulation of microtubule-based organelle localization" EXACT [GOC:TermGenie] is_a: GO:0032386 ! regulation of intracellular transport is_a: GO:0060632 ! regulation of microtubule-based movement intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0072384 ! regulates organelle transport along microtubule relationship: RO:0002211 GO:0072384 ! regulates organelle transport along microtubule creation_date: 2013-11-15T20:15:17Z [Term] id: GO:1902531 name: regulation of intracellular signal transduction namespace: biological_process def: "Any process that modulates the frequency, rate or extent of intracellular signal transduction." [GOC:dph, GOC:signaling, GOC:tb, GOC:TermGenie] synonym: "regulation of intracellular protein kinase cascade" NARROW [] synonym: "regulation of intracellular signal transduction pathway" NARROW [GOC:TermGenie] synonym: "regulation of intracellular signaling cascade" EXACT [GOC:TermGenie] synonym: "regulation of intracellular signaling chain" EXACT [GOC:TermGenie] synonym: "regulation of intracellular signaling pathway" RELATED [GOC:TermGenie] synonym: "regulation of signal transduction via intracellular signaling cascade" RELATED [GOC:TermGenie] synonym: "regulation of signal transmission via intracellular cascade" NARROW [GOC:TermGenie] is_a: GO:0009966 ! regulation of signal transduction intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0035556 ! regulates intracellular signal transduction relationship: RO:0002211 GO:0035556 ! regulates intracellular signal transduction creation_date: 2013-12-02T11:32:52Z [Term] id: GO:1902532 name: negative regulation of intracellular signal transduction namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of intracellular signal transduction." [GOC:dph, GOC:signaling, GOC:tb, GOC:TermGenie] synonym: "down regulation of intracellular signal transduction" EXACT [GOC:TermGenie] synonym: "down regulation of intracellular signal transduction pathway" NARROW [GOC:TermGenie] synonym: "down regulation of intracellular signaling cascade" NARROW [GOC:TermGenie] synonym: "down regulation of intracellular signaling chain" EXACT [GOC:TermGenie] synonym: "down regulation of intracellular signaling pathway" RELATED [GOC:TermGenie] synonym: "down regulation of signal transduction via intracellular signaling cascade" RELATED [GOC:TermGenie] synonym: "down regulation of signal transmission via intracellular cascade" NARROW [GOC:TermGenie] synonym: "down-regulation of intracellular signal transduction" EXACT [GOC:TermGenie] synonym: "down-regulation of intracellular signal transduction pathway" NARROW [GOC:TermGenie] synonym: "down-regulation of intracellular signaling cascade" RELATED [GOC:TermGenie] synonym: "down-regulation of intracellular signaling chain" EXACT [GOC:TermGenie] synonym: "down-regulation of intracellular signaling pathway" RELATED [GOC:TermGenie] synonym: "down-regulation of signal transduction via intracellular signaling cascade" RELATED [GOC:TermGenie] synonym: "down-regulation of signal transmission via intracellular cascade" RELATED [GOC:TermGenie] synonym: "downregulation of intracellular signal transduction" EXACT [GOC:TermGenie] synonym: "downregulation of intracellular signal transduction pathway" NARROW [GOC:TermGenie] synonym: "downregulation of intracellular signaling cascade" NARROW [GOC:TermGenie] synonym: "downregulation of intracellular signaling chain" EXACT [GOC:TermGenie] synonym: "downregulation of intracellular signaling pathway" RELATED [GOC:TermGenie] synonym: "downregulation of signal transduction via intracellular signaling cascade" RELATED [GOC:TermGenie] synonym: "downregulation of signal transmission via intracellular cascade" NARROW [GOC:TermGenie] synonym: "inhibition of intracellular signal transduction" NARROW [GOC:TermGenie] synonym: "inhibition of intracellular signal transduction pathway" NARROW [GOC:TermGenie] synonym: "inhibition of intracellular signaling cascade" NARROW [GOC:TermGenie] synonym: "inhibition of intracellular signaling chain" NARROW [GOC:TermGenie] synonym: "inhibition of intracellular signaling pathway" RELATED [GOC:TermGenie] synonym: "inhibition of signal transduction via intracellular signaling cascade" RELATED [GOC:TermGenie] synonym: "inhibition of signal transmission via intracellular cascade" NARROW [GOC:TermGenie] synonym: "negative regulation of intracellular protein kinase cascade" EXACT [] synonym: "negative regulation of intracellular signal transduction pathway" NARROW [GOC:TermGenie] synonym: "negative regulation of intracellular signaling cascade" EXACT [GOC:TermGenie] synonym: "negative regulation of intracellular signaling chain" EXACT [GOC:TermGenie] synonym: "negative regulation of intracellular signaling pathway" RELATED [GOC:TermGenie] synonym: "negative regulation of signal transduction via intracellular signaling cascade" RELATED [GOC:TermGenie] synonym: "negative regulation of signal transmission via intracellular cascade" NARROW [GOC:TermGenie] is_a: GO:0009968 ! negative regulation of signal transduction is_a: GO:1902531 ! regulation of intracellular signal transduction intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0035556 ! negatively regulates intracellular signal transduction relationship: RO:0002212 GO:0035556 ! negatively regulates intracellular signal transduction creation_date: 2013-12-02T11:33:01Z [Term] id: GO:1902533 name: positive regulation of intracellular signal transduction namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of intracellular signal transduction." [GOC:BHF, GOC:dph, GOC:signaling, GOC:tb, GOC:TermGenie] synonym: "activation of intracellular signal transduction" NARROW [GOC:TermGenie] synonym: "activation of intracellular signal transduction pathway" NARROW [GOC:TermGenie] synonym: "activation of intracellular signaling cascade" NARROW [GOC:TermGenie] synonym: "activation of intracellular signaling chain" NARROW [GOC:TermGenie] synonym: "activation of intracellular signaling pathway" RELATED [GOC:TermGenie] synonym: "activation of signal transduction via intracellular signaling cascade" RELATED [GOC:TermGenie] synonym: "activation of signal transmission via intracellular cascade" NARROW [GOC:TermGenie] synonym: "positive regulation of intracellular protein kinase cascade" NARROW [] synonym: "positive regulation of intracellular signal transduction pathway" NARROW [GOC:TermGenie] synonym: "positive regulation of intracellular signaling cascade" RELATED [GOC:TermGenie] synonym: "positive regulation of intracellular signaling chain" EXACT [GOC:TermGenie] synonym: "positive regulation of intracellular signaling pathway" RELATED [GOC:TermGenie] synonym: "positive regulation of signal transduction via intracellular signaling cascade" RELATED [GOC:TermGenie] synonym: "positive regulation of signal transmission via intracellular cascade" NARROW [GOC:TermGenie] synonym: "up regulation of intracellular signal transduction" EXACT [GOC:TermGenie] synonym: "up regulation of intracellular signal transduction pathway" NARROW [GOC:TermGenie] synonym: "up regulation of intracellular signaling cascade" RELATED [GOC:TermGenie] synonym: "up regulation of intracellular signaling chain" EXACT [GOC:TermGenie] synonym: "up regulation of intracellular signaling pathway" RELATED [GOC:TermGenie] synonym: "up regulation of signal transduction via intracellular signaling cascade" RELATED [GOC:TermGenie] synonym: "up regulation of signal transmission via intracellular cascade" NARROW [GOC:TermGenie] synonym: "up-regulation of intracellular signal transduction" EXACT [GOC:TermGenie] synonym: "up-regulation of intracellular signal transduction pathway" NARROW [GOC:TermGenie] synonym: "up-regulation of intracellular signaling cascade" RELATED [GOC:TermGenie] synonym: "up-regulation of intracellular signaling chain" EXACT [GOC:TermGenie] synonym: "up-regulation of intracellular signaling pathway" RELATED [GOC:TermGenie] synonym: "up-regulation of signal transduction via intracellular signaling cascade" RELATED [GOC:TermGenie] synonym: "up-regulation of signal transmission via intracellular cascade" NARROW [GOC:TermGenie] synonym: "upregulation of intracellular signal transduction" EXACT [GOC:TermGenie] synonym: "upregulation of intracellular signal transduction pathway" NARROW [GOC:TermGenie] synonym: "upregulation of intracellular signaling cascade" RELATED [GOC:TermGenie] synonym: "upregulation of intracellular signaling chain" EXACT [GOC:TermGenie] synonym: "upregulation of intracellular signaling pathway" RELATED [GOC:TermGenie] synonym: "upregulation of signal transduction via intracellular signaling cascade" RELATED [GOC:TermGenie] synonym: "upregulation of signal transmission via intracellular cascade" NARROW [GOC:TermGenie] is_a: GO:0009967 ! positive regulation of signal transduction is_a: GO:1902531 ! regulation of intracellular signal transduction intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0035556 ! positively regulates intracellular signal transduction relationship: RO:0002213 GO:0035556 ! positively regulates intracellular signal transduction creation_date: 2013-12-02T11:33:10Z [Term] id: GO:1902563 name: regulation of neutrophil activation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of neutrophil activation." [GOC:TermGenie, PMID:17588661] is_a: GO:0002694 ! regulation of leukocyte activation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0042119 ! regulates neutrophil activation relationship: RO:0002211 GO:0042119 ! regulates neutrophil activation creation_date: 2013-12-10T15:33:08Z [Term] id: GO:1902564 name: negative regulation of neutrophil activation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of neutrophil activation." [GOC:TermGenie, PMID:17588661] synonym: "down regulation of neutrophil activation" EXACT [GOC:TermGenie] synonym: "down-regulation of neutrophil activation" EXACT [GOC:TermGenie] synonym: "downregulation of neutrophil activation" EXACT [GOC:TermGenie] synonym: "inhibition of neutrophil activation" NARROW [GOC:TermGenie] is_a: GO:0002695 ! negative regulation of leukocyte activation is_a: GO:1902563 ! regulation of neutrophil activation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0042119 ! negatively regulates neutrophil activation relationship: RO:0002212 GO:0042119 ! negatively regulates neutrophil activation creation_date: 2013-12-10T15:33:16Z [Term] id: GO:1902565 name: positive regulation of neutrophil activation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of neutrophil activation." [GOC:TermGenie, PMID:17588661] synonym: "activation of neutrophil activation" NARROW [GOC:TermGenie] synonym: "up regulation of neutrophil activation" EXACT [GOC:TermGenie] synonym: "up-regulation of neutrophil activation" EXACT [GOC:TermGenie] synonym: "upregulation of neutrophil activation" EXACT [GOC:TermGenie] is_a: GO:0002696 ! positive regulation of leukocyte activation is_a: GO:1902563 ! regulation of neutrophil activation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0042119 ! positively regulates neutrophil activation relationship: RO:0002213 GO:0042119 ! positively regulates neutrophil activation creation_date: 2013-12-10T15:33:26Z [Term] id: GO:1902566 name: regulation of eosinophil activation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of eosinophil activation." [GOC:TermGenie, PMID:16254138] is_a: GO:0002694 ! regulation of leukocyte activation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0043307 ! regulates eosinophil activation relationship: RO:0002211 GO:0043307 ! regulates eosinophil activation creation_date: 2013-12-10T15:54:35Z [Term] id: GO:1902567 name: negative regulation of eosinophil activation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of eosinophil activation." [GOC:TermGenie, PMID:16254138] synonym: "down regulation of eosinophil activation" EXACT [GOC:TermGenie] synonym: "down-regulation of eosinophil activation" EXACT [GOC:TermGenie] synonym: "downregulation of eosinophil activation" EXACT [GOC:TermGenie] synonym: "inhibition of eosinophil activation" NARROW [GOC:TermGenie] is_a: GO:0002695 ! negative regulation of leukocyte activation is_a: GO:1902566 ! regulation of eosinophil activation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0043307 ! negatively regulates eosinophil activation relationship: RO:0002212 GO:0043307 ! negatively regulates eosinophil activation creation_date: 2013-12-10T15:54:43Z [Term] id: GO:1902568 name: positive regulation of eosinophil activation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of eosinophil activation." [GOC:TermGenie, PMID:16254138] synonym: "activation of eosinophil activation" NARROW [GOC:TermGenie] synonym: "up regulation of eosinophil activation" EXACT [GOC:TermGenie] synonym: "up-regulation of eosinophil activation" EXACT [GOC:TermGenie] synonym: "upregulation of eosinophil activation" EXACT [GOC:TermGenie] is_a: GO:0002696 ! positive regulation of leukocyte activation is_a: GO:1902566 ! regulation of eosinophil activation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0043307 ! positively regulates eosinophil activation relationship: RO:0002213 GO:0043307 ! positively regulates eosinophil activation creation_date: 2013-12-10T15:54:52Z [Term] id: GO:1902570 name: protein localization to nucleolus namespace: biological_process def: "A process in which a protein is transported to, or maintained in, a location within a nucleolus." [GOC:TermGenie, PMID:22809626] synonym: "protein localisation in nucleolus" EXACT [GOC:TermGenie] synonym: "protein localisation to nucleolus" EXACT [GOC:TermGenie] synonym: "protein localization in nucleolus" EXACT [GOC:TermGenie] is_a: GO:0034504 ! protein localization to nucleus intersection_of: GO:0008104 ! intracellular protein localization intersection_of: RO:0002339 GO:0005730 ! has target end location nucleolus relationship: RO:0002339 GO:0005730 ! has target end location nucleolus creation_date: 2013-12-10T16:25:28Z [Term] id: GO:1902584 name: positive regulation of response to water deprivation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of response to water deprivation." [GO_REF:0000058, GOC:TermGenie, PMID:24198318] synonym: "activation of drought tolerance" RELATED [GOC:TermGenie] synonym: "activation of response to dehydration" NARROW [GOC:TermGenie] synonym: "activation of response to drought" NARROW [GOC:TermGenie] synonym: "activation of response to thirst" NARROW [GOC:TermGenie] synonym: "activation of response to water deprivation" NARROW [GOC:TermGenie] synonym: "positive regulation of drought tolerance" RELATED [GOC:TermGenie] synonym: "positive regulation of response to dehydration" EXACT [GOC:TermGenie] synonym: "positive regulation of response to drought" EXACT [GOC:TermGenie] synonym: "positive regulation of response to thirst" EXACT [GOC:TermGenie] synonym: "up regulation of drought tolerance" RELATED [GOC:TermGenie] synonym: "up regulation of response to dehydration" EXACT [GOC:TermGenie] synonym: "up regulation of response to drought" EXACT [GOC:TermGenie] synonym: "up regulation of response to thirst" EXACT [GOC:TermGenie] synonym: "up regulation of response to water deprivation" EXACT [GOC:TermGenie] synonym: "up-regulation of drought tolerance" RELATED [GOC:TermGenie] synonym: "up-regulation of response to dehydration" EXACT [GOC:TermGenie] synonym: "up-regulation of response to drought" EXACT [GOC:TermGenie] synonym: "up-regulation of response to thirst" EXACT [GOC:TermGenie] synonym: "up-regulation of response to water deprivation" EXACT [GOC:TermGenie] synonym: "upregulation of drought tolerance" RELATED [GOC:TermGenie] synonym: "upregulation of response to dehydration" EXACT [GOC:TermGenie] synonym: "upregulation of response to drought" EXACT [GOC:TermGenie] synonym: "upregulation of response to thirst" EXACT [GOC:TermGenie] synonym: "upregulation of response to water deprivation" EXACT [GOC:TermGenie] is_a: GO:0048584 ! positive regulation of response to stimulus is_a: GO:2000070 ! regulation of response to water deprivation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0009414 ! positively regulates response to water deprivation relationship: RO:0002213 GO:0009414 ! positively regulates response to water deprivation creation_date: 2013-12-19T00:31:58Z [Term] id: GO:1902600 name: proton transmembrane transport namespace: biological_process def: "The directed movement of a proton across a membrane." [GO_REF:0000069, GOC:pr, GOC:TermGenie] subset: goslim_pir synonym: "ATP hydrolysis coupled proton transport" NARROW [] synonym: "hydrogen ion transmembrane transport" EXACT [] synonym: "hydrogen ion transport" RELATED [] synonym: "hydrogen transmembrane transport" EXACT [] synonym: "hydrogen transport" BROAD [] synonym: "passive proton transport, down the electrochemical gradient" NARROW [] synonym: "proton transport" BROAD [] xref: Reactome:R-HSA-167826 "The fatty acid cycling model" is_a: GO:0098655 ! monoatomic cation transmembrane transport intersection_of: GO:0055085 ! transmembrane transport intersection_of: RO:0004009 CHEBI:15378 ! has primary input relationship: RO:0004009 CHEBI:15378 ! has primary input creation_date: 2013-12-20T11:08:37Z [Term] id: GO:1902622 name: regulation of neutrophil migration namespace: biological_process def: "Any process that modulates the frequency, rate or extent of neutrophil migration." [GO_REF:0000058, GOC:TermGenie, PMID:1826836] is_a: GO:0002685 ! regulation of leukocyte migration intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:1990266 ! regulates neutrophil migration relationship: RO:0002211 GO:1990266 ! regulates neutrophil migration creation_date: 2014-01-15T18:58:39Z [Term] id: GO:1902623 name: negative regulation of neutrophil migration namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of neutrophil migration." [GO_REF:0000058, GOC:TermGenie, PMID:1826836] synonym: "down regulation of neutrophil migration" EXACT [GOC:TermGenie] synonym: "down-regulation of neutrophil migration" EXACT [GOC:TermGenie] synonym: "downregulation of neutrophil migration" EXACT [GOC:TermGenie] synonym: "inhibition of neutrophil migration" NARROW [GOC:TermGenie] is_a: GO:0002686 ! negative regulation of leukocyte migration is_a: GO:1902622 ! regulation of neutrophil migration intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:1990266 ! negatively regulates neutrophil migration relationship: RO:0002212 GO:1990266 ! negatively regulates neutrophil migration creation_date: 2014-01-15T18:58:49Z [Term] id: GO:1902624 name: positive regulation of neutrophil migration namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of neutrophil migration." [GO_REF:0000058, GOC:TermGenie, PMID:1826836] synonym: "activation of neutrophil migration" NARROW [GOC:TermGenie] synonym: "up regulation of neutrophil migration" EXACT [GOC:TermGenie] synonym: "up-regulation of neutrophil migration" EXACT [GOC:TermGenie] synonym: "upregulation of neutrophil migration" EXACT [GOC:TermGenie] is_a: GO:0002687 ! positive regulation of leukocyte migration is_a: GO:1902622 ! regulation of neutrophil migration intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:1990266 ! positively regulates neutrophil migration relationship: RO:0002213 GO:1990266 ! positively regulates neutrophil migration creation_date: 2014-01-15T18:58:58Z [Term] id: GO:1902637 name: neural crest cell differentiation involved in thymus development namespace: biological_process def: "Any neural crest cell differentiation that is involved in thymus development." [GO_REF:0000060, GOC:nhn, GOC:TermGenie, PMID:15741317, PMID:18292542] is_a: GO:0014033 ! neural crest cell differentiation intersection_of: GO:0014033 ! neural crest cell differentiation intersection_of: BFO:0000050 GO:0048538 ! part of thymus development relationship: BFO:0000050 GO:0048538 ! part of thymus development creation_date: 2014-01-21T10:03:20Z [Term] id: GO:1902638 name: neural crest cell differentiation involved in parathyroid gland development namespace: biological_process def: "Any neural crest cell differentiation that is involved in parathyroid gland development." [GO_REF:0000060, GOC:nhn, GOC:TermGenie, PMID:15741317] is_a: GO:0014033 ! neural crest cell differentiation intersection_of: GO:0014033 ! neural crest cell differentiation intersection_of: BFO:0000050 GO:0060017 ! part of parathyroid gland development relationship: BFO:0000050 GO:0060017 ! part of parathyroid gland development creation_date: 2014-01-21T10:03:29Z [Term] id: GO:1902656 name: calcium ion import into cytosol namespace: biological_process def: "The directed movement of calcium ion into a cytosol." [GO_REF:0000075, GOC:TermGenie, GOC:vw] synonym: "calcium import into cytosol" BROAD [] is_a: GO:0006816 ! calcium ion transport relationship: RO:0002339 GO:0005829 ! has target end location cytosol creation_date: 2014-01-22T13:41:11Z [Term] id: GO:1902679 name: negative regulation of RNA biosynthetic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of RNA biosynthetic process." [GO:jl, GO_REF:0000058, GOC:TermGenie] synonym: "down regulation of RNA anabolism" EXACT [GOC:TermGenie] synonym: "down regulation of RNA biosynthesis" EXACT [GOC:TermGenie] synonym: "down regulation of RNA biosynthetic process" EXACT [GOC:TermGenie] synonym: "down regulation of RNA formation" EXACT [GOC:TermGenie] synonym: "down regulation of RNA synthesis" EXACT [GOC:TermGenie] synonym: "down-regulation of RNA anabolism" EXACT [GOC:TermGenie] synonym: "down-regulation of RNA biosynthesis" EXACT [GOC:TermGenie] synonym: "down-regulation of RNA biosynthetic process" EXACT [GOC:TermGenie] synonym: "down-regulation of RNA formation" EXACT [GOC:TermGenie] synonym: "down-regulation of RNA synthesis" EXACT [GOC:TermGenie] synonym: "downregulation of RNA anabolism" EXACT [GOC:TermGenie] synonym: "downregulation of RNA biosynthesis" EXACT [GOC:TermGenie] synonym: "downregulation of RNA biosynthetic process" EXACT [GOC:TermGenie] synonym: "downregulation of RNA formation" EXACT [GOC:TermGenie] synonym: "downregulation of RNA synthesis" EXACT [GOC:TermGenie] synonym: "inhibition of RNA anabolism" NARROW [GOC:TermGenie] synonym: "inhibition of RNA biosynthesis" NARROW [GOC:TermGenie] synonym: "inhibition of RNA biosynthetic process" NARROW [GOC:TermGenie] synonym: "inhibition of RNA formation" NARROW [GOC:TermGenie] synonym: "inhibition of RNA synthesis" NARROW [GOC:TermGenie] synonym: "negative regulation of RNA anabolism" EXACT [GOC:TermGenie] synonym: "negative regulation of RNA biosynthesis" EXACT [GOC:TermGenie] synonym: "negative regulation of RNA formation" EXACT [GOC:TermGenie] synonym: "negative regulation of RNA synthesis" EXACT [GOC:TermGenie] is_a: GO:0010558 ! negative regulation of macromolecule biosynthetic process is_a: GO:0051253 ! negative regulation of RNA metabolic process is_a: GO:2001141 ! regulation of RNA biosynthetic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0032774 ! negatively regulates RNA biosynthetic process relationship: RO:0002212 GO:0032774 ! negatively regulates RNA biosynthetic process creation_date: 2014-02-05T16:32:01Z [Term] id: GO:1902680 name: positive regulation of RNA biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of RNA biosynthetic process." [GO:jl, GO_REF:0000058, GOC:TermGenie] synonym: "activation of RNA anabolism" NARROW [GOC:TermGenie] synonym: "activation of RNA biosynthesis" NARROW [GOC:TermGenie] synonym: "activation of RNA biosynthetic process" NARROW [GOC:TermGenie] synonym: "activation of RNA formation" NARROW [GOC:TermGenie] synonym: "activation of RNA synthesis" NARROW [GOC:TermGenie] synonym: "positive regulation of RNA anabolism" EXACT [GOC:TermGenie] synonym: "positive regulation of RNA biosynthesis" EXACT [GOC:TermGenie] synonym: "positive regulation of RNA formation" EXACT [GOC:TermGenie] synonym: "positive regulation of RNA synthesis" EXACT [GOC:TermGenie] synonym: "up regulation of RNA anabolism" EXACT [GOC:TermGenie] synonym: "up regulation of RNA biosynthesis" EXACT [GOC:TermGenie] synonym: "up regulation of RNA biosynthetic process" EXACT [GOC:TermGenie] synonym: "up regulation of RNA formation" EXACT [GOC:TermGenie] synonym: "up regulation of RNA synthesis" EXACT [GOC:TermGenie] synonym: "up-regulation of RNA anabolism" EXACT [GOC:TermGenie] synonym: "up-regulation of RNA biosynthesis" EXACT [GOC:TermGenie] synonym: "up-regulation of RNA biosynthetic process" EXACT [GOC:TermGenie] synonym: "up-regulation of RNA formation" EXACT [GOC:TermGenie] synonym: "up-regulation of RNA synthesis" EXACT [GOC:TermGenie] synonym: "upregulation of RNA anabolism" EXACT [GOC:TermGenie] synonym: "upregulation of RNA biosynthesis" EXACT [GOC:TermGenie] synonym: "upregulation of RNA biosynthetic process" EXACT [GOC:TermGenie] synonym: "upregulation of RNA formation" EXACT [GOC:TermGenie] synonym: "upregulation of RNA synthesis" EXACT [GOC:TermGenie] is_a: GO:0010557 ! positive regulation of macromolecule biosynthetic process is_a: GO:0051254 ! positive regulation of RNA metabolic process is_a: GO:2001141 ! regulation of RNA biosynthetic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0032774 ! positively regulates RNA biosynthetic process relationship: RO:0002213 GO:0032774 ! positively regulates RNA biosynthetic process creation_date: 2014-02-05T16:32:10Z [Term] id: GO:1902683 name: regulation of receptor localization to synapse namespace: biological_process def: "Any process that modulates the frequency, rate or extent of receptor localization to synapse." [GO_REF:0000058, GOC:kmv, GOC:TermGenie, PMID:22252129] synonym: "regulation of receptor localisation to synapse" EXACT [GOC:TermGenie] is_a: GO:0032879 ! regulation of localization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0097120 ! regulates receptor localization to synapse relationship: RO:0002211 GO:0097120 ! regulates receptor localization to synapse creation_date: 2014-02-07T17:38:31Z [Term] id: GO:1902684 name: negative regulation of receptor localization to synapse namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of receptor localization to synapse." [GO_REF:0000058, GOC:kmv, GOC:TermGenie, PMID:22252129] synonym: "down regulation of receptor localisation to synapse" EXACT [GOC:TermGenie] synonym: "down regulation of receptor localization to synapse" EXACT [GOC:TermGenie] synonym: "down-regulation of receptor localisation to synapse" EXACT [GOC:TermGenie] synonym: "down-regulation of receptor localization to synapse" EXACT [GOC:TermGenie] synonym: "downregulation of receptor localisation to synapse" EXACT [GOC:TermGenie] synonym: "downregulation of receptor localization to synapse" EXACT [GOC:TermGenie] synonym: "inhibition of receptor localisation to synapse" NARROW [GOC:TermGenie] synonym: "inhibition of receptor localization to synapse" NARROW [GOC:TermGenie] synonym: "negative regulation of receptor localisation to synapse" EXACT [GOC:TermGenie] is_a: GO:0048519 ! negative regulation of biological process is_a: GO:1902683 ! regulation of receptor localization to synapse intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0097120 ! negatively regulates receptor localization to synapse relationship: RO:0002212 GO:0097120 ! negatively regulates receptor localization to synapse creation_date: 2014-02-07T17:38:41Z [Term] id: GO:1902685 name: positive regulation of receptor localization to synapse namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of receptor localization to synapse." [GO_REF:0000058, GOC:kmv, GOC:TermGenie, PMID:22252129] synonym: "activation of receptor localisation to synapse" NARROW [GOC:TermGenie] synonym: "activation of receptor localization to synapse" NARROW [GOC:TermGenie] synonym: "positive regulation of receptor localisation to synapse" EXACT [GOC:TermGenie] synonym: "up regulation of receptor localisation to synapse" EXACT [GOC:TermGenie] synonym: "up regulation of receptor localization to synapse" EXACT [GOC:TermGenie] synonym: "up-regulation of receptor localisation to synapse" EXACT [GOC:TermGenie] synonym: "up-regulation of receptor localization to synapse" EXACT [GOC:TermGenie] synonym: "upregulation of receptor localisation to synapse" EXACT [GOC:TermGenie] synonym: "upregulation of receptor localization to synapse" EXACT [GOC:TermGenie] is_a: GO:0048518 ! positive regulation of biological process is_a: GO:1902683 ! regulation of receptor localization to synapse intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0097120 ! positively regulates receptor localization to synapse relationship: RO:0002213 GO:0097120 ! positively regulates receptor localization to synapse creation_date: 2014-02-07T17:38:51Z [Term] id: GO:1902691 name: respiratory basal cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires the specialized features of a respiratory basal cell." [GO_REF:0000086, GOC:TermGenie, MP:0011114, PMID:17909629] comment: Changes in the lineage choice of ABCs or their undifferentiated daughters might contribute to the mucous cell hyperplasia, metaplasia or squamous metaplasia seen in many respiratory disorders synonym: "airway basal cell differentiation" EXACT [MP:0011114] is_a: GO:0048863 ! stem cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0002633 ! results in acquisition of features of respiratory basal cell relationship: RO:0002315 CL:0002633 ! results in acquisition of features of respiratory basal cell creation_date: 2014-02-13T23:41:24Z [Term] id: GO:1902692 name: regulation of neuroblast proliferation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of neuroblast proliferation." [GO_REF:0000058, GOC:PARL, GOC:rl, GOC:TermGenie, PMID:21168496] is_a: GO:2000177 ! regulation of neural precursor cell proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0007405 ! regulates neuroblast proliferation relationship: RO:0002211 GO:0007405 ! regulates neuroblast proliferation creation_date: 2014-02-18T10:03:31Z [Term] id: GO:1902710 name: GABA receptor complex namespace: cellular_component def: "A protein complex which is capable of GABA receptor activity. Upon binding of gamma-aminobutyric acid (GABA) it transmits the signal from one side of the membrane to the other to initiate a change in cell activity. Major inhibitory receptor in vertebrate brain. Also found in other vertebrate tissues, invertebrates and possibly in plants. Effective benzodiazepine receptor." [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:18790874] synonym: "gamma-aminobutyric acid receptor complex" EXACT [] is_a: GO:0043235 ! receptor complex intersection_of: GO:0032991 ! protein-containing complex intersection_of: RO:0002215 GO:0016917 ! capable of GABA receptor activity relationship: RO:0002215 GO:0016917 ! capable of GABA receptor activity creation_date: 2014-02-20T16:07:48Z [Term] id: GO:1902721 name: negative regulation of prolactin secretion namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of prolactin secretion." [GO_REF:0000058, GOC:TermGenie, PMID:16159377] synonym: "down regulation of prolactin secretion" EXACT [GOC:TermGenie] synonym: "down-regulation of prolactin secretion" EXACT [GOC:TermGenie] synonym: "downregulation of prolactin secretion" EXACT [GOC:TermGenie] synonym: "inhibition of prolactin secretion" NARROW [GOC:TermGenie] is_a: GO:0050709 ! negative regulation of protein secretion is_a: GO:0090278 ! negative regulation of peptide hormone secretion intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0070459 ! negatively regulates prolactin secretion relationship: RO:0002212 GO:0070459 ! negatively regulates prolactin secretion creation_date: 2014-02-24T16:09:28Z [Term] id: GO:1902722 name: positive regulation of prolactin secretion namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of prolactin secretion." [GO_REF:0000058, GOC:TermGenie, PMID:16159377] synonym: "activation of prolactin secretion" NARROW [GOC:TermGenie] synonym: "up regulation of prolactin secretion" EXACT [GOC:TermGenie] synonym: "up-regulation of prolactin secretion" EXACT [GOC:TermGenie] synonym: "upregulation of prolactin secretion" EXACT [GOC:TermGenie] is_a: GO:0050714 ! positive regulation of protein secretion is_a: GO:0090277 ! positive regulation of peptide hormone secretion intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0070459 ! positively regulates prolactin secretion relationship: RO:0002213 GO:0070459 ! positively regulates prolactin secretion creation_date: 2014-02-24T16:09:37Z [Term] id: GO:1902723 name: negative regulation of skeletal muscle satellite cell proliferation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of satellite cell proliferation." [GO_REF:0000058, GOC:TermGenie, PMID:23212449] synonym: "down regulation of satellite cell proliferation" EXACT [GOC:TermGenie] synonym: "down-regulation of satellite cell proliferation" EXACT [GOC:TermGenie] synonym: "downregulation of satellite cell proliferation" EXACT [GOC:TermGenie] synonym: "inhibition of satellite cell proliferation" NARROW [GOC:TermGenie] is_a: GO:0014842 ! regulation of skeletal muscle satellite cell proliferation is_a: GO:0014859 ! negative regulation of skeletal muscle cell proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0014841 ! negatively regulates skeletal muscle satellite cell proliferation relationship: RO:0002212 GO:0014841 ! negatively regulates skeletal muscle satellite cell proliferation property_value: RO:0002161 NCBITaxon:4751 creation_date: 2014-02-24T16:09:46Z [Term] id: GO:1902724 name: positive regulation of skeletal muscle satellite cell proliferation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of skeletal muscle satellite cell proliferation." [GO_REF:0000058, GOC:TermGenie, PMID:23212449] synonym: "activation of satellite cell proliferation" NARROW [GOC:TermGenie] synonym: "up regulation of satellite cell proliferation" EXACT [GOC:TermGenie] synonym: "up-regulation of satellite cell proliferation" EXACT [GOC:TermGenie] synonym: "upregulation of satellite cell proliferation" EXACT [GOC:TermGenie] is_a: GO:0014842 ! regulation of skeletal muscle satellite cell proliferation is_a: GO:0014858 ! positive regulation of skeletal muscle cell proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0014841 ! positively regulates skeletal muscle satellite cell proliferation relationship: RO:0002213 GO:0014841 ! positively regulates skeletal muscle satellite cell proliferation property_value: RO:0002161 NCBITaxon:4751 creation_date: 2014-02-24T16:09:56Z [Term] id: GO:1902725 name: negative regulation of satellite cell differentiation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of satellite cell differentiation." [GO_REF:0000058, GOC:TermGenie, PMID:23212449] synonym: "down regulation of satellite cell differentiation" EXACT [GOC:TermGenie] synonym: "down-regulation of satellite cell differentiation" EXACT [GOC:TermGenie] synonym: "downregulation of satellite cell differentiation" EXACT [GOC:TermGenie] synonym: "inhibition of satellite cell differentiation" NARROW [GOC:TermGenie] is_a: GO:2001015 ! negative regulation of skeletal muscle cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0014816 ! negatively regulates skeletal muscle satellite cell differentiation relationship: RO:0002212 GO:0014816 ! negatively regulates skeletal muscle satellite cell differentiation creation_date: 2014-02-24T16:10:05Z [Term] id: GO:1902726 name: positive regulation of skeletal muscle satellite cell differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of satellite cell differentiation." [GO_REF:0000058, GOC:TermGenie, PMID:23212449] synonym: "activation of satellite cell differentiation" NARROW [GOC:TermGenie] synonym: "up regulation of satellite cell differentiation" EXACT [GOC:TermGenie] synonym: "up-regulation of satellite cell differentiation" EXACT [GOC:TermGenie] synonym: "upregulation of satellite cell differentiation" EXACT [GOC:TermGenie] is_a: GO:2001016 ! positive regulation of skeletal muscle cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0014816 ! positively regulates skeletal muscle satellite cell differentiation relationship: RO:0002213 GO:0014816 ! positively regulates skeletal muscle satellite cell differentiation creation_date: 2014-02-24T16:10:14Z [Term] id: GO:1902729 name: negative regulation of proteoglycan biosynthetic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteoglycans, any glycoprotein in which the carbohydrate units are glycosaminoglycans." [GO_REF:0000058, GOC:TermGenie, PMID:23212449] synonym: "down regulation of proteoglycan anabolism" EXACT [GOC:TermGenie] synonym: "down regulation of proteoglycan biosynthesis" EXACT [GOC:TermGenie] synonym: "down regulation of proteoglycan biosynthetic process" EXACT [GOC:TermGenie] synonym: "down regulation of proteoglycan formation" EXACT [GOC:TermGenie] synonym: "down regulation of proteoglycan synthesis" EXACT [GOC:TermGenie] synonym: "down-regulation of proteoglycan anabolism" EXACT [GOC:TermGenie] synonym: "down-regulation of proteoglycan biosynthesis" EXACT [GOC:TermGenie] synonym: "down-regulation of proteoglycan biosynthetic process" EXACT [GOC:TermGenie] synonym: "down-regulation of proteoglycan formation" EXACT [GOC:TermGenie] synonym: "down-regulation of proteoglycan synthesis" EXACT [GOC:TermGenie] synonym: "downregulation of proteoglycan anabolism" EXACT [GOC:TermGenie] synonym: "downregulation of proteoglycan biosynthesis" EXACT [GOC:TermGenie] synonym: "downregulation of proteoglycan biosynthetic process" EXACT [GOC:TermGenie] synonym: "downregulation of proteoglycan formation" EXACT [GOC:TermGenie] synonym: "downregulation of proteoglycan synthesis" EXACT [GOC:TermGenie] synonym: "inhibition of proteoglycan anabolism" NARROW [GOC:TermGenie] synonym: "inhibition of proteoglycan biosynthesis" NARROW [GOC:TermGenie] synonym: "inhibition of proteoglycan biosynthetic process" NARROW [GOC:TermGenie] synonym: "inhibition of proteoglycan formation" NARROW [GOC:TermGenie] synonym: "inhibition of proteoglycan synthesis" NARROW [GOC:TermGenie] synonym: "negative regulation of proteoglycan anabolism" EXACT [GOC:TermGenie] synonym: "negative regulation of proteoglycan biosynthesis" EXACT [GOC:TermGenie] synonym: "negative regulation of proteoglycan formation" EXACT [GOC:TermGenie] synonym: "negative regulation of proteoglycan synthesis" EXACT [GOC:TermGenie] is_a: GO:0010561 ! negative regulation of glycoprotein biosynthetic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0030166 ! negatively regulates proteoglycan biosynthetic process relationship: RO:0002212 GO:0030166 ! negatively regulates proteoglycan biosynthetic process creation_date: 2014-02-24T16:10:43Z [Term] id: GO:1902730 name: positive regulation of proteoglycan biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteoglycans, any glycoprotein in which the carbohydrate units are glycosaminoglycans." [GO_REF:0000058, GOC:TermGenie, PMID:23212449] synonym: "activation of proteoglycan anabolism" NARROW [GOC:TermGenie] synonym: "activation of proteoglycan biosynthesis" NARROW [GOC:TermGenie] synonym: "activation of proteoglycan biosynthetic process" NARROW [GOC:TermGenie] synonym: "activation of proteoglycan formation" NARROW [GOC:TermGenie] synonym: "activation of proteoglycan synthesis" NARROW [GOC:TermGenie] synonym: "positive regulation of proteoglycan anabolism" EXACT [GOC:TermGenie] synonym: "positive regulation of proteoglycan biosynthesis" EXACT [GOC:TermGenie] synonym: "positive regulation of proteoglycan formation" EXACT [GOC:TermGenie] synonym: "positive regulation of proteoglycan synthesis" EXACT [GOC:TermGenie] synonym: "up regulation of proteoglycan anabolism" EXACT [GOC:TermGenie] synonym: "up regulation of proteoglycan biosynthesis" EXACT [GOC:TermGenie] synonym: "up regulation of proteoglycan biosynthetic process" EXACT [GOC:TermGenie] synonym: "up regulation of proteoglycan formation" EXACT [GOC:TermGenie] synonym: "up regulation of proteoglycan synthesis" EXACT [GOC:TermGenie] synonym: "up-regulation of proteoglycan anabolism" EXACT [GOC:TermGenie] synonym: "up-regulation of proteoglycan biosynthesis" EXACT [GOC:TermGenie] synonym: "up-regulation of proteoglycan biosynthetic process" EXACT [GOC:TermGenie] synonym: "up-regulation of proteoglycan formation" EXACT [GOC:TermGenie] synonym: "up-regulation of proteoglycan synthesis" EXACT [GOC:TermGenie] synonym: "upregulation of proteoglycan anabolism" EXACT [GOC:TermGenie] synonym: "upregulation of proteoglycan biosynthesis" EXACT [GOC:TermGenie] synonym: "upregulation of proteoglycan biosynthetic process" EXACT [GOC:TermGenie] synonym: "upregulation of proteoglycan formation" EXACT [GOC:TermGenie] synonym: "upregulation of proteoglycan synthesis" EXACT [GOC:TermGenie] is_a: GO:0010560 ! positive regulation of glycoprotein biosynthetic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0030166 ! positively regulates proteoglycan biosynthetic process relationship: RO:0002213 GO:0030166 ! positively regulates proteoglycan biosynthetic process creation_date: 2014-02-24T16:10:52Z [Term] id: GO:1902733 name: regulation of growth plate cartilage chondrocyte differentiation namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of the process in which a chondroblast acquires specialized structural and/or functional features of a chondrocyte that will contribute to the growth of a bone. A chondrocyte is a polymorphic cell that forms cartilage." [GO_REF:0000058, GOC:TermGenie, PMID:23212449] is_a: GO:1902738 ! regulation of chondrocyte differentiation involved in endochondral bone morphogenesis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0003418 ! regulates growth plate cartilage chondrocyte differentiation relationship: RO:0002211 GO:0003418 ! regulates growth plate cartilage chondrocyte differentiation creation_date: 2014-02-24T16:11:28Z [Term] id: GO:1902738 name: regulation of chondrocyte differentiation involved in endochondral bone morphogenesis namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of the process in which a chondroblast acquires specialized structural and/or functional features of a chondrocyte that will contribute to the development of a bone. A chondrocyte is a polymorphic cell that forms cartilage." [GO_REF:0000058, GOC:TermGenie, PMID:8662546] is_a: GO:0032330 ! regulation of chondrocyte differentiation is_a: GO:1903010 ! regulation of bone development is_a: GO:2000027 ! regulation of animal organ morphogenesis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0003413 ! regulates chondrocyte differentiation involved in endochondral bone morphogenesis relationship: RO:0002211 GO:0003413 ! regulates chondrocyte differentiation involved in endochondral bone morphogenesis creation_date: 2014-02-26T15:36:15Z [Term] id: GO:1902742 name: apoptotic process involved in development namespace: biological_process def: "Any apoptotic process that is involved in anatomical structure development." [GO_REF:0000060, GOC:mtg_apoptosis, GOC:pg, GOC:TermGenie] synonym: "activation of apoptosis involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "activation of apoptosis involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "apoptosis activator activity involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "apoptosis activator activity involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "apoptosis involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "apoptosis involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "apoptosis signaling involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "apoptosis signaling involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "apoptotic cell death involved in anatomical structure development" EXACT [GOC:TermGenie] synonym: "apoptotic cell death involved in development of an anatomical structure" EXACT [GOC:TermGenie] synonym: "apoptotic process involved in anatomical structure development" EXACT [] synonym: "apoptotic process involved in development of an anatomical structure" EXACT [GOC:TermGenie] synonym: "apoptotic program involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "apoptotic program involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "apoptotic programmed cell death involved in anatomical structure development" EXACT [GOC:TermGenie] synonym: "apoptotic programmed cell death involved in development of an anatomical structure" EXACT [GOC:TermGenie] synonym: "commitment to apoptosis involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "commitment to apoptosis involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "induction of apoptosis by p53 involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "induction of apoptosis by p53 involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "induction of apoptosis involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "induction of apoptosis involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "programmed cell death by apoptosis involved in anatomical structure development" EXACT [GOC:TermGenie] synonym: "programmed cell death by apoptosis involved in development of an anatomical structure" EXACT [GOC:TermGenie] synonym: "signaling (initiator) caspase activity involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "signaling (initiator) caspase activity involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "type I programmed cell death involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "type I programmed cell death involved in development of an anatomical structure" NARROW [GOC:TermGenie] is_a: GO:0006915 ! apoptotic process intersection_of: GO:0006915 ! apoptotic process intersection_of: BFO:0000050 GO:0048856 ! part of anatomical structure development relationship: BFO:0000050 GO:0048856 ! part of anatomical structure development property_value: RO:0002161 NCBITaxon:4896 creation_date: 2014-02-28T13:09:43Z [Term] id: GO:1902746 name: regulation of lens fiber cell differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of lens fiber cell differentiation." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:17592637] synonym: "regulation of lens fibre cell differentiation" EXACT [GOC:TermGenie] is_a: GO:0030856 ! regulation of epithelial cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0070306 ! regulates lens fiber cell differentiation relationship: RO:0002211 GO:0070306 ! regulates lens fiber cell differentiation creation_date: 2014-03-03T23:18:50Z [Term] id: GO:1902747 name: negative regulation of lens fiber cell differentiation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of lens fiber cell differentiation." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:17592637] synonym: "down regulation of lens fiber cell differentiation" EXACT [GOC:TermGenie] synonym: "down regulation of lens fibre cell differentiation" EXACT [GOC:TermGenie] synonym: "down-regulation of lens fiber cell differentiation" EXACT [GOC:TermGenie] synonym: "down-regulation of lens fibre cell differentiation" EXACT [GOC:TermGenie] synonym: "downregulation of lens fiber cell differentiation" EXACT [GOC:TermGenie] synonym: "downregulation of lens fibre cell differentiation" EXACT [GOC:TermGenie] synonym: "inhibition of lens fiber cell differentiation" NARROW [GOC:TermGenie] synonym: "inhibition of lens fibre cell differentiation" NARROW [GOC:TermGenie] synonym: "negative regulation of lens fibre cell differentiation" EXACT [GOC:TermGenie] is_a: GO:0030857 ! negative regulation of epithelial cell differentiation is_a: GO:0051241 ! negative regulation of multicellular organismal process is_a: GO:1902746 ! regulation of lens fiber cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0070306 ! negatively regulates lens fiber cell differentiation relationship: RO:0002212 GO:0070306 ! negatively regulates lens fiber cell differentiation creation_date: 2014-03-03T23:19:32Z [Term] id: GO:1902748 name: positive regulation of lens fiber cell differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of lens fiber cell differentiation." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:17592637] synonym: "activation of lens fiber cell differentiation" NARROW [GOC:TermGenie] synonym: "activation of lens fibre cell differentiation" NARROW [GOC:TermGenie] synonym: "positive regulation of lens fibre cell differentiation" EXACT [GOC:TermGenie] synonym: "up regulation of lens fiber cell differentiation" EXACT [GOC:TermGenie] synonym: "up regulation of lens fibre cell differentiation" EXACT [GOC:TermGenie] synonym: "up-regulation of lens fiber cell differentiation" EXACT [GOC:TermGenie] synonym: "up-regulation of lens fibre cell differentiation" EXACT [GOC:TermGenie] synonym: "upregulation of lens fiber cell differentiation" EXACT [GOC:TermGenie] synonym: "upregulation of lens fibre cell differentiation" EXACT [GOC:TermGenie] is_a: GO:0030858 ! positive regulation of epithelial cell differentiation is_a: GO:0051240 ! positive regulation of multicellular organismal process is_a: GO:1902746 ! regulation of lens fiber cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0070306 ! positively regulates lens fiber cell differentiation relationship: RO:0002213 GO:0070306 ! positively regulates lens fiber cell differentiation creation_date: 2014-03-03T23:20:12Z [Term] id: GO:1902761 name: positive regulation of chondrocyte development namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of chondrocyte development." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:16575901] synonym: "activation of chondrocyte development" NARROW [GOC:TermGenie] synonym: "up regulation of chondrocyte development" EXACT [GOC:TermGenie] synonym: "up-regulation of chondrocyte development" EXACT [GOC:TermGenie] synonym: "upregulation of chondrocyte development" EXACT [GOC:TermGenie] is_a: GO:0010720 ! positive regulation of cell development is_a: GO:0032332 ! positive regulation of chondrocyte differentiation is_a: GO:0061181 ! regulation of chondrocyte development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0002063 ! positively regulates chondrocyte development relationship: RO:0002213 GO:0002063 ! positively regulates chondrocyte development creation_date: 2014-03-07T17:45:55Z [Term] id: GO:1902766 name: skeletal muscle satellite cell migration namespace: biological_process def: "The orderly movement of a skeletal muscle satellite cell from one site to another. Migration of these cells is a key step in the process of growth and repair of skeletal muscle cells." [GO_REF:0000091, GOC:mr, GOC:TermGenie, PMID:17996437, PMID:19609936] is_a: BFO:0000003 is_a: GO:0016477 ! cell migration intersection_of: GO:0016477 ! cell migration intersection_of: RO:0002565 CL:0000594 ! results in movement of skeletal muscle satellite cell relationship: RO:0002565 CL:0000594 ! results in movement of skeletal muscle satellite cell property_value: RO:0002161 NCBITaxon:4890 creation_date: 2014-03-10T15:20:28Z [Term] id: GO:1902809 name: regulation of skeletal muscle fiber differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of skeletal muscle fiber differentiation." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:17879321] is_a: GO:0010830 ! regulation of myotube differentiation is_a: GO:2001014 ! regulation of skeletal muscle cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0098528 ! regulates skeletal muscle fiber differentiation relationship: RO:0002211 GO:0098528 ! regulates skeletal muscle fiber differentiation creation_date: 2014-03-26T21:18:26Z [Term] id: GO:1902810 name: negative regulation of skeletal muscle fiber differentiation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of skeletal muscle fiber differentiation." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:17879321] synonym: "down regulation of skeletal muscle fiber differentiation" EXACT [GOC:TermGenie] synonym: "down-regulation of skeletal muscle fiber differentiation" EXACT [GOC:TermGenie] synonym: "downregulation of skeletal muscle fiber differentiation" EXACT [GOC:TermGenie] synonym: "inhibition of skeletal muscle fiber differentiation" NARROW [GOC:TermGenie] is_a: GO:0010832 ! negative regulation of myotube differentiation is_a: GO:1902809 ! regulation of skeletal muscle fiber differentiation is_a: GO:2001015 ! negative regulation of skeletal muscle cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0098528 ! negatively regulates skeletal muscle fiber differentiation relationship: RO:0002212 GO:0098528 ! negatively regulates skeletal muscle fiber differentiation creation_date: 2014-03-26T21:18:32Z [Term] id: GO:1902811 name: positive regulation of skeletal muscle fiber differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of skeletal muscle fiber differentiation." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:17879321] synonym: "activation of skeletal muscle fiber differentiation" NARROW [GOC:TermGenie] synonym: "up regulation of skeletal muscle fiber differentiation" EXACT [GOC:TermGenie] synonym: "up-regulation of skeletal muscle fiber differentiation" EXACT [GOC:TermGenie] synonym: "upregulation of skeletal muscle fiber differentiation" EXACT [GOC:TermGenie] is_a: GO:0010831 ! positive regulation of myotube differentiation is_a: GO:1902809 ! regulation of skeletal muscle fiber differentiation is_a: GO:2001016 ! positive regulation of skeletal muscle cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0098528 ! positively regulates skeletal muscle fiber differentiation relationship: RO:0002213 GO:0098528 ! positively regulates skeletal muscle fiber differentiation creation_date: 2014-03-26T21:18:38Z [Term] id: GO:1902816 name: regulation of protein localization to microtubule namespace: biological_process def: "Any process that modulates the frequency, rate or extent of protein localization to microtubule." [GO_REF:0000058, GOC:TermGenie, GOC:vw, PMID:23087209] synonym: "regulation of protein localisation to microtubule" EXACT [GOC:TermGenie] is_a: GO:0032880 ! regulation of protein localization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0035372 ! regulates protein localization to microtubule relationship: RO:0002211 GO:0035372 ! regulates protein localization to microtubule creation_date: 2014-03-27T22:07:12Z [Term] id: GO:1902817 name: negative regulation of protein localization to microtubule namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to microtubule." [GO_REF:0000058, GOC:TermGenie, GOC:vw, PMID:23087209] synonym: "down regulation of protein localisation to microtubule" EXACT [GOC:TermGenie] synonym: "down regulation of protein localization to microtubule" EXACT [GOC:TermGenie] synonym: "down-regulation of protein localisation to microtubule" EXACT [GOC:TermGenie] synonym: "down-regulation of protein localization to microtubule" EXACT [GOC:TermGenie] synonym: "downregulation of protein localisation to microtubule" EXACT [GOC:TermGenie] synonym: "downregulation of protein localization to microtubule" EXACT [GOC:TermGenie] synonym: "inhibition of protein localisation to microtubule" NARROW [GOC:TermGenie] synonym: "inhibition of protein localization to microtubule" NARROW [GOC:TermGenie] synonym: "negative regulation of protein localisation to microtubule" EXACT [GOC:TermGenie] is_a: GO:1902816 ! regulation of protein localization to microtubule is_a: GO:1903828 ! negative regulation of protein localization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0035372 ! negatively regulates protein localization to microtubule relationship: RO:0002212 GO:0035372 ! negatively regulates protein localization to microtubule creation_date: 2014-03-27T22:07:18Z [Term] id: GO:1902832 name: negative regulation of cell proliferation in dorsal spinal cord namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of cell proliferation in dorsal spinal cord." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:21730158] synonym: "down regulation of cell proliferation in dorsal spinal cord" EXACT [GOC:TermGenie] synonym: "down-regulation of cell proliferation in dorsal spinal cord" EXACT [GOC:TermGenie] synonym: "downregulation of cell proliferation in dorsal spinal cord" EXACT [GOC:TermGenie] synonym: "inhibition of cell proliferation in dorsal spinal cord" NARROW [GOC:TermGenie] is_a: GO:0021921 ! regulation of cell proliferation in dorsal spinal cord is_a: GO:2000178 ! negative regulation of neural precursor cell proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0010456 ! negatively regulates cell proliferation in dorsal spinal cord relationship: RO:0002212 GO:0010456 ! negatively regulates cell proliferation in dorsal spinal cord creation_date: 2014-03-31T17:42:50Z [Term] id: GO:1902833 name: positive regulation of cell proliferation in dorsal spinal cord namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cell proliferation in dorsal spinal cord." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:21730158] synonym: "activation of cell proliferation in dorsal spinal cord" NARROW [GOC:TermGenie] synonym: "up regulation of cell proliferation in dorsal spinal cord" EXACT [GOC:TermGenie] synonym: "up-regulation of cell proliferation in dorsal spinal cord" EXACT [GOC:TermGenie] synonym: "upregulation of cell proliferation in dorsal spinal cord" EXACT [GOC:TermGenie] is_a: GO:0021921 ! regulation of cell proliferation in dorsal spinal cord is_a: GO:2000179 ! positive regulation of neural precursor cell proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0010456 ! positively regulates cell proliferation in dorsal spinal cord relationship: RO:0002213 GO:0010456 ! positively regulates cell proliferation in dorsal spinal cord creation_date: 2014-03-31T17:43:33Z [Term] id: GO:1902838 name: regulation of nuclear migration along microtubule namespace: biological_process def: "Any process that modulates the frequency, rate or extent of nuclear migration along microtubule." [GO_REF:0000058, GOC:TermGenie, PMID:23087209] synonym: "regulation of microtubule cytoskeleton-dependent nuclear positioning" EXACT [GOC:TermGenie] synonym: "regulation of microtubule cytoskeleton-dependent nucleus positioning" EXACT [GOC:TermGenie] synonym: "regulation of microtubule-dependent nuclear positioning" EXACT [GOC:TermGenie] synonym: "regulation of microtubule-dependent nucleus positioning" EXACT [GOC:TermGenie] synonym: "regulation of microtubule-mediated nuclear migration" EXACT [GOC:TermGenie] synonym: "regulation of nuclear migration, microtubule-mediated" EXACT [GOC:TermGenie] synonym: "regulation of nuclear movement, microtubule-mediated" BROAD [GOC:TermGenie] synonym: "regulation of nucleus migration" BROAD [GOC:TermGenie] synonym: "regulation of transport of nucleus by microtubules" EXACT [GOC:TermGenie] synonym: "regulation of transport of nucleus, microtubule-mediated" EXACT [GOC:TermGenie] is_a: GO:1902513 ! regulation of organelle transport along microtubule intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0030473 ! regulates nuclear migration along microtubule relationship: RO:0002211 GO:0030473 ! regulates nuclear migration along microtubule creation_date: 2014-04-01T13:50:23Z [Term] id: GO:1902839 name: negative regulation of nuclear migration along microtubule namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of nuclear migration along microtubule." [GO_REF:0000058, GOC:TermGenie, PMID:23087209] synonym: "down regulation of microtubule cytoskeleton-dependent nuclear positioning" EXACT [GOC:TermGenie] synonym: "down regulation of microtubule cytoskeleton-dependent nucleus positioning" EXACT [GOC:TermGenie] synonym: "down regulation of microtubule-dependent nuclear positioning" EXACT [GOC:TermGenie] synonym: "down regulation of microtubule-dependent nucleus positioning" EXACT [GOC:TermGenie] synonym: "down regulation of microtubule-mediated nuclear migration" EXACT [GOC:TermGenie] synonym: "down regulation of nuclear migration along microtubule" EXACT [GOC:TermGenie] synonym: "down regulation of nuclear migration, microtubule-mediated" EXACT [GOC:TermGenie] synonym: "down regulation of transport of nucleus by microtubules" EXACT [GOC:TermGenie] synonym: "down regulation of transport of nucleus, microtubule-mediated" EXACT [GOC:TermGenie] synonym: "down-regulation of microtubule cytoskeleton-dependent nuclear positioning" EXACT [GOC:TermGenie] synonym: "down-regulation of microtubule cytoskeleton-dependent nucleus positioning" EXACT [GOC:TermGenie] synonym: "down-regulation of microtubule-dependent nuclear positioning" EXACT [GOC:TermGenie] synonym: "down-regulation of microtubule-dependent nucleus positioning" EXACT [GOC:TermGenie] synonym: "down-regulation of microtubule-mediated nuclear migration" EXACT [GOC:TermGenie] synonym: "down-regulation of nuclear migration along microtubule" EXACT [GOC:TermGenie] synonym: "down-regulation of nuclear migration, microtubule-mediated" EXACT [GOC:TermGenie] synonym: "down-regulation of transport of nucleus by microtubules" EXACT [GOC:TermGenie] synonym: "down-regulation of transport of nucleus, microtubule-mediated" EXACT [GOC:TermGenie] synonym: "downregulation of microtubule cytoskeleton-dependent nuclear positioning" EXACT [GOC:TermGenie] synonym: "downregulation of microtubule cytoskeleton-dependent nucleus positioning" EXACT [GOC:TermGenie] synonym: "downregulation of microtubule-dependent nuclear positioning" EXACT [GOC:TermGenie] synonym: "downregulation of microtubule-dependent nucleus positioning" EXACT [GOC:TermGenie] synonym: "downregulation of microtubule-mediated nuclear migration" EXACT [GOC:TermGenie] synonym: "downregulation of nuclear migration along microtubule" EXACT [GOC:TermGenie] synonym: "downregulation of nuclear migration, microtubule-mediated" EXACT [GOC:TermGenie] synonym: "downregulation of transport of nucleus by microtubules" EXACT [GOC:TermGenie] synonym: "downregulation of transport of nucleus, microtubule-mediated" EXACT [GOC:TermGenie] synonym: "inhibition of microtubule cytoskeleton-dependent nuclear positioning" NARROW [GOC:TermGenie] synonym: "inhibition of microtubule cytoskeleton-dependent nucleus positioning" NARROW [GOC:TermGenie] synonym: "inhibition of microtubule-dependent nuclear positioning" NARROW [GOC:TermGenie] synonym: "inhibition of microtubule-dependent nucleus positioning" NARROW [GOC:TermGenie] synonym: "inhibition of microtubule-mediated nuclear migration" NARROW [GOC:TermGenie] synonym: "inhibition of nuclear migration along microtubule" NARROW [GOC:TermGenie] synonym: "inhibition of nuclear migration, microtubule-mediated" NARROW [GOC:TermGenie] synonym: "inhibition of transport of nucleus by microtubules" NARROW [GOC:TermGenie] synonym: "inhibition of transport of nucleus, microtubule-mediated" NARROW [GOC:TermGenie] synonym: "negative regulation of microtubule cytoskeleton-dependent nuclear positioning" EXACT [GOC:TermGenie] synonym: "negative regulation of microtubule cytoskeleton-dependent nucleus positioning" EXACT [GOC:TermGenie] synonym: "negative regulation of microtubule-dependent nuclear positioning" EXACT [GOC:TermGenie] synonym: "negative regulation of microtubule-dependent nucleus positioning" EXACT [GOC:TermGenie] synonym: "negative regulation of microtubule-mediated nuclear migration" EXACT [GOC:TermGenie] synonym: "negative regulation of nuclear migration, microtubule-mediated" EXACT [GOC:TermGenie] synonym: "negative regulation of transport of nucleus by microtubules" EXACT [GOC:TermGenie] synonym: "negative regulation of transport of nucleus, microtubule-mediated" EXACT [GOC:TermGenie] is_a: GO:0032387 ! negative regulation of intracellular transport is_a: GO:1902838 ! regulation of nuclear migration along microtubule intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0030473 ! negatively regulates nuclear migration along microtubule relationship: RO:0002212 GO:0030473 ! negatively regulates nuclear migration along microtubule creation_date: 2014-04-01T13:50:29Z [Term] id: GO:1902840 name: positive regulation of nuclear migration along microtubule namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of nuclear migration along microtubule." [GO_REF:0000058, GOC:TermGenie, PMID:23087209] synonym: "activation of microtubule cytoskeleton-dependent nuclear positioning" NARROW [GOC:TermGenie] synonym: "activation of microtubule cytoskeleton-dependent nucleus positioning" NARROW [GOC:TermGenie] synonym: "activation of microtubule-dependent nuclear positioning" NARROW [GOC:TermGenie] synonym: "activation of microtubule-dependent nucleus positioning" NARROW [GOC:TermGenie] synonym: "activation of microtubule-mediated nuclear migration" NARROW [GOC:TermGenie] synonym: "activation of nuclear migration along microtubule" NARROW [GOC:TermGenie] synonym: "activation of nuclear migration, microtubule-mediated" NARROW [GOC:TermGenie] synonym: "activation of transport of nucleus by microtubules" NARROW [GOC:TermGenie] synonym: "activation of transport of nucleus, microtubule-mediated" NARROW [GOC:TermGenie] synonym: "positive regulation of microtubule cytoskeleton-dependent nuclear positioning" EXACT [GOC:TermGenie] synonym: "positive regulation of microtubule cytoskeleton-dependent nucleus positioning" EXACT [GOC:TermGenie] synonym: "positive regulation of microtubule-dependent nuclear positioning" EXACT [GOC:TermGenie] synonym: "positive regulation of microtubule-dependent nucleus positioning" EXACT [GOC:TermGenie] synonym: "positive regulation of microtubule-mediated nuclear migration" EXACT [GOC:TermGenie] synonym: "positive regulation of nuclear migration, microtubule-mediated" EXACT [GOC:TermGenie] synonym: "positive regulation of transport of nucleus by microtubules" EXACT [GOC:TermGenie] synonym: "positive regulation of transport of nucleus, microtubule-mediated" EXACT [GOC:TermGenie] synonym: "up regulation of microtubule cytoskeleton-dependent nuclear positioning" EXACT [GOC:TermGenie] synonym: "up regulation of microtubule cytoskeleton-dependent nucleus positioning" EXACT [GOC:TermGenie] synonym: "up regulation of microtubule-dependent nuclear positioning" EXACT [GOC:TermGenie] synonym: "up regulation of microtubule-dependent nucleus positioning" EXACT [GOC:TermGenie] synonym: "up regulation of microtubule-mediated nuclear migration" EXACT [GOC:TermGenie] synonym: "up regulation of nuclear migration along microtubule" EXACT [GOC:TermGenie] synonym: "up regulation of nuclear migration, microtubule-mediated" EXACT [GOC:TermGenie] synonym: "up regulation of transport of nucleus by microtubules" EXACT [GOC:TermGenie] synonym: "up regulation of transport of nucleus, microtubule-mediated" EXACT [GOC:TermGenie] synonym: "up-regulation of microtubule cytoskeleton-dependent nuclear positioning" EXACT [GOC:TermGenie] synonym: "up-regulation of microtubule cytoskeleton-dependent nucleus positioning" EXACT [GOC:TermGenie] synonym: "up-regulation of microtubule-dependent nuclear positioning" EXACT [GOC:TermGenie] synonym: "up-regulation of microtubule-dependent nucleus positioning" EXACT [GOC:TermGenie] synonym: "up-regulation of microtubule-mediated nuclear migration" EXACT [GOC:TermGenie] synonym: "up-regulation of nuclear migration along microtubule" EXACT [GOC:TermGenie] synonym: "up-regulation of nuclear migration, microtubule-mediated" EXACT [GOC:TermGenie] synonym: "up-regulation of transport of nucleus by microtubules" EXACT [GOC:TermGenie] synonym: "up-regulation of transport of nucleus, microtubule-mediated" EXACT [GOC:TermGenie] synonym: "upregulation of microtubule cytoskeleton-dependent nuclear positioning" EXACT [GOC:TermGenie] synonym: "upregulation of microtubule cytoskeleton-dependent nucleus positioning" EXACT [GOC:TermGenie] synonym: "upregulation of microtubule-dependent nuclear positioning" EXACT [GOC:TermGenie] synonym: "upregulation of microtubule-dependent nucleus positioning" EXACT [GOC:TermGenie] synonym: "upregulation of microtubule-mediated nuclear migration" EXACT [GOC:TermGenie] synonym: "upregulation of nuclear migration along microtubule" EXACT [GOC:TermGenie] synonym: "upregulation of nuclear migration, microtubule-mediated" EXACT [GOC:TermGenie] synonym: "upregulation of transport of nucleus by microtubules" EXACT [GOC:TermGenie] synonym: "upregulation of transport of nucleus, microtubule-mediated" EXACT [GOC:TermGenie] is_a: GO:0032388 ! positive regulation of intracellular transport is_a: GO:1902838 ! regulation of nuclear migration along microtubule intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0030473 ! positively regulates nuclear migration along microtubule relationship: RO:0002213 GO:0030473 ! positively regulates nuclear migration along microtubule creation_date: 2014-04-01T13:50:35Z [Term] id: GO:1902850 name: microtubule cytoskeleton organization involved in mitosis namespace: biological_process def: "Any microtubule cytoskeleton organization that is involved in mitosis." [GO_REF:0000060, GOC:TermGenie, PMID:18799626] synonym: "microtubule cytoskeleton organisation involved in mitosis" EXACT [GOC:TermGenie] synonym: "microtubule cytoskeleton organization and biogenesis involved in mitosis" RELATED [GOC:TermGenie] synonym: "microtubule dynamics involved in mitosis" EXACT [GOC:TermGenie] is_a: GO:0000226 ! microtubule cytoskeleton organization is_a: GO:1903047 ! mitotic cell cycle process intersection_of: GO:0000226 ! microtubule cytoskeleton organization intersection_of: BFO:0000050 GO:0000278 ! part of mitotic cell cycle creation_date: 2014-04-02T14:19:38Z [Term] id: GO:1902855 name: regulation of non-motile cilium assembly namespace: biological_process def: "Any process that modulates the frequency, rate or extent of non-motile cilium assembly." [GO_REF:0000058, GOC:cilia, GOC:kmv, GOC:TermGenie, PMID:23807208] synonym: "regulation of immotile primary cilium assembly" RELATED [GOC:TermGenie] synonym: "regulation of nonmotile primary cilia assembly" RELATED [GOC:TermGenie] synonym: "regulation of nonmotile primary cilium assembly" RELATED [] synonym: "regulation of sensory cilium assembly" RELATED [GOC:TermGenie] synonym: "regulation of sensory cilium biogenesis" RELATED [GOC:TermGenie] is_a: GO:1902017 ! regulation of cilium assembly intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:1905515 ! regulates non-motile cilium assembly relationship: RO:0002211 GO:1905515 ! regulates non-motile cilium assembly property_value: RO:0002161 NCBITaxon:3176 property_value: RO:0002161 NCBITaxon:3378 property_value: RO:0002161 NCBITaxon:3398 property_value: RO:0002161 NCBITaxon:4751 property_value: RO:0002161 NCBITaxon:5782 creation_date: 2014-04-02T15:41:57Z [Term] id: GO:1902856 name: negative regulation of non-motile cilium assembly namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of non-motile cilium assembly." [GO_REF:0000058, GOC:cilia, GOC:kmv, GOC:TermGenie, PMID:23807208] synonym: "down regulation of immotile primary cilium assembly" RELATED [GOC:TermGenie] synonym: "down regulation of nonmotile primary cilia assembly" RELATED [GOC:TermGenie] synonym: "down regulation of nonmotile primary cilium assembly" RELATED [GOC:TermGenie] synonym: "down regulation of sensory cilium assembly" RELATED [GOC:TermGenie] synonym: "down regulation of sensory cilium biogenesis" RELATED [GOC:TermGenie] synonym: "down-regulation of immotile primary cilium assembly" RELATED [GOC:TermGenie] synonym: "down-regulation of nonmotile primary cilia assembly" RELATED [GOC:TermGenie] synonym: "down-regulation of nonmotile primary cilium assembly" RELATED [GOC:TermGenie] synonym: "down-regulation of sensory cilium assembly" RELATED [GOC:TermGenie] synonym: "down-regulation of sensory cilium biogenesis" RELATED [GOC:TermGenie] synonym: "downregulation of immotile primary cilium assembly" RELATED [GOC:TermGenie] synonym: "downregulation of nonmotile primary cilia assembly" RELATED [GOC:TermGenie] synonym: "downregulation of nonmotile primary cilium assembly" RELATED [GOC:TermGenie] synonym: "downregulation of sensory cilium assembly" RELATED [GOC:TermGenie] synonym: "downregulation of sensory cilium biogenesis" RELATED [GOC:TermGenie] synonym: "inhibition of immotile primary cilium assembly" NARROW [GOC:TermGenie] synonym: "inhibition of nonmotile primary cilia assembly" RELATED [GOC:TermGenie] synonym: "inhibition of nonmotile primary cilium assembly" NARROW [GOC:TermGenie] synonym: "inhibition of sensory cilium assembly" NARROW [GOC:TermGenie] synonym: "inhibition of sensory cilium biogenesis" RELATED [GOC:TermGenie] synonym: "negative regulation of immotile primary cilium assembly" RELATED [GOC:TermGenie] synonym: "negative regulation of nonmotile primary cilia assembly" RELATED [GOC:TermGenie] synonym: "negative regulation of nonmotile primary cilium assembly" RELATED [] synonym: "negative regulation of sensory cilium assembly" RELATED [GOC:TermGenie] synonym: "negative regulation of sensory cilium biogenesis" RELATED [GOC:TermGenie] is_a: GO:1902018 ! negative regulation of cilium assembly is_a: GO:1902855 ! regulation of non-motile cilium assembly intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:1905515 ! negatively regulates non-motile cilium assembly relationship: RO:0002212 GO:1905515 ! negatively regulates non-motile cilium assembly property_value: RO:0002161 NCBITaxon:3176 property_value: RO:0002161 NCBITaxon:3378 property_value: RO:0002161 NCBITaxon:3398 property_value: RO:0002161 NCBITaxon:4751 property_value: RO:0002161 NCBITaxon:5782 creation_date: 2014-04-02T15:42:17Z [Term] id: GO:1902857 name: positive regulation of non-motile cilium assembly namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of non-motile cilium assembly." [GO_REF:0000058, GOC:cilia, GOC:kmv, GOC:TermGenie, PMID:23807208] synonym: "activation of immotile primary cilium assembly" NARROW [GOC:TermGenie] synonym: "activation of nonmotile primary cilia assembly" RELATED [GOC:TermGenie] synonym: "activation of nonmotile primary cilium assembly" NARROW [GOC:TermGenie] synonym: "activation of sensory cilium assembly" NARROW [GOC:TermGenie] synonym: "activation of sensory cilium biogenesis" RELATED [GOC:TermGenie] synonym: "positive regulation of immotile primary cilium assembly" RELATED [GOC:TermGenie] synonym: "positive regulation of nonmotile primary cilia assembly" RELATED [GOC:TermGenie] synonym: "positive regulation of nonmotile primary cilium assembly" RELATED [] synonym: "positive regulation of sensory cilium assembly" RELATED [GOC:TermGenie] synonym: "positive regulation of sensory cilium biogenesis" RELATED [GOC:TermGenie] synonym: "up regulation of immotile primary cilium assembly" RELATED [GOC:TermGenie] synonym: "up regulation of nonmotile primary cilia assembly" RELATED [GOC:TermGenie] synonym: "up regulation of nonmotile primary cilium assembly" RELATED [GOC:TermGenie] synonym: "up regulation of sensory cilium assembly" RELATED [GOC:TermGenie] synonym: "up regulation of sensory cilium biogenesis" RELATED [GOC:TermGenie] synonym: "up-regulation of immotile primary cilium assembly" RELATED [GOC:TermGenie] synonym: "up-regulation of nonmotile primary cilia assembly" RELATED [GOC:TermGenie] synonym: "up-regulation of nonmotile primary cilium assembly" RELATED [GOC:TermGenie] synonym: "up-regulation of sensory cilium assembly" RELATED [GOC:TermGenie] synonym: "up-regulation of sensory cilium biogenesis" RELATED [GOC:TermGenie] synonym: "upregulation of immotile primary cilium assembly" RELATED [GOC:TermGenie] synonym: "upregulation of nonmotile primary cilia assembly" RELATED [GOC:TermGenie] synonym: "upregulation of nonmotile primary cilium assembly" RELATED [GOC:TermGenie] synonym: "upregulation of sensory cilium assembly" RELATED [GOC:TermGenie] synonym: "upregulation of sensory cilium biogenesis" RELATED [GOC:TermGenie] is_a: GO:0045724 ! positive regulation of cilium assembly is_a: GO:1902855 ! regulation of non-motile cilium assembly intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:1905515 ! positively regulates non-motile cilium assembly relationship: RO:0002213 GO:1905515 ! positively regulates non-motile cilium assembly property_value: RO:0002161 NCBITaxon:3176 property_value: RO:0002161 NCBITaxon:3378 property_value: RO:0002161 NCBITaxon:3398 property_value: RO:0002161 NCBITaxon:4751 property_value: RO:0002161 NCBITaxon:5782 creation_date: 2014-04-02T15:42:31Z [Term] id: GO:1902863 name: regulation of embryonic camera-type eye development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of embryonic camera-type eye development." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:16872597] synonym: "regulation of embryonic eye development" EXACT [GOC:TermGenie] is_a: GO:0050793 ! regulation of developmental process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0031076 ! regulates embryonic camera-type eye development relationship: RO:0002211 GO:0031076 ! regulates embryonic camera-type eye development creation_date: 2014-04-03T15:24:00Z [Term] id: GO:1902864 name: negative regulation of embryonic camera-type eye development namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of embryonic camera-type eye development." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:16872597] synonym: "down regulation of embryonic camera-type eye development" EXACT [GOC:TermGenie] synonym: "down regulation of embryonic eye development" EXACT [GOC:TermGenie] synonym: "down-regulation of embryonic camera-type eye development" EXACT [GOC:TermGenie] synonym: "down-regulation of embryonic eye development" EXACT [GOC:TermGenie] synonym: "downregulation of embryonic camera-type eye development" EXACT [GOC:TermGenie] synonym: "downregulation of embryonic eye development" EXACT [GOC:TermGenie] synonym: "inhibition of embryonic camera-type eye development" NARROW [GOC:TermGenie] synonym: "inhibition of embryonic eye development" NARROW [GOC:TermGenie] synonym: "negative regulation of embryonic eye development" EXACT [GOC:TermGenie] is_a: GO:0051093 ! negative regulation of developmental process is_a: GO:1902863 ! regulation of embryonic camera-type eye development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0031076 ! negatively regulates embryonic camera-type eye development relationship: RO:0002212 GO:0031076 ! negatively regulates embryonic camera-type eye development creation_date: 2014-04-03T15:24:06Z [Term] id: GO:1902865 name: positive regulation of embryonic camera-type eye development namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of embryonic camera-type eye development." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:16872597] synonym: "activation of embryonic camera-type eye development" NARROW [GOC:TermGenie] synonym: "activation of embryonic eye development" NARROW [GOC:TermGenie] synonym: "positive regulation of embryonic eye development" EXACT [GOC:TermGenie] synonym: "up regulation of embryonic camera-type eye development" EXACT [GOC:TermGenie] synonym: "up regulation of embryonic eye development" EXACT [GOC:TermGenie] synonym: "up-regulation of embryonic camera-type eye development" EXACT [GOC:TermGenie] synonym: "up-regulation of embryonic eye development" EXACT [GOC:TermGenie] synonym: "upregulation of embryonic camera-type eye development" EXACT [GOC:TermGenie] synonym: "upregulation of embryonic eye development" EXACT [GOC:TermGenie] is_a: GO:0051094 ! positive regulation of developmental process is_a: GO:1902863 ! regulation of embryonic camera-type eye development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0031076 ! positively regulates embryonic camera-type eye development relationship: RO:0002213 GO:0031076 ! positively regulates embryonic camera-type eye development creation_date: 2014-04-03T15:24:12Z [Term] id: GO:1902866 name: regulation of retina development in camera-type eye namespace: biological_process def: "Any process that modulates the frequency, rate or extent of retina development in camera-type eye." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:16872597] synonym: "regulation of retina development in camera-style eye" EXACT [GOC:TermGenie] synonym: "regulation of retinal development" RELATED [GOC:TermGenie] is_a: GO:0050793 ! regulation of developmental process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0060041 ! regulates retina development in camera-type eye relationship: RO:0002211 GO:0060041 ! regulates retina development in camera-type eye creation_date: 2014-04-03T15:24:17Z [Term] id: GO:1902867 name: negative regulation of retina development in camera-type eye namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of retina development in camera-type eye." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:16872597] synonym: "down regulation of retina development in camera-style eye" EXACT [GOC:TermGenie] synonym: "down regulation of retina development in camera-type eye" EXACT [GOC:TermGenie] synonym: "down regulation of retinal development" RELATED [GOC:TermGenie] synonym: "down-regulation of retina development in camera-style eye" EXACT [GOC:TermGenie] synonym: "down-regulation of retina development in camera-type eye" EXACT [GOC:TermGenie] synonym: "down-regulation of retinal development" RELATED [GOC:TermGenie] synonym: "downregulation of retina development in camera-style eye" EXACT [GOC:TermGenie] synonym: "downregulation of retina development in camera-type eye" EXACT [GOC:TermGenie] synonym: "downregulation of retinal development" RELATED [GOC:TermGenie] synonym: "inhibition of retina development in camera-style eye" NARROW [GOC:TermGenie] synonym: "inhibition of retina development in camera-type eye" NARROW [GOC:TermGenie] synonym: "inhibition of retinal development" RELATED [GOC:TermGenie] synonym: "negative regulation of retina development in camera-style eye" EXACT [GOC:TermGenie] synonym: "negative regulation of retinal development" RELATED [GOC:TermGenie] is_a: GO:0051093 ! negative regulation of developmental process is_a: GO:0051241 ! negative regulation of multicellular organismal process is_a: GO:1902866 ! regulation of retina development in camera-type eye intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0060041 ! negatively regulates retina development in camera-type eye relationship: RO:0002212 GO:0060041 ! negatively regulates retina development in camera-type eye creation_date: 2014-04-03T15:24:23Z [Term] id: GO:1902868 name: positive regulation of retina development in camera-type eye namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of retina development in camera-type eye." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:16872597] synonym: "activation of retina development in camera-style eye" NARROW [GOC:TermGenie] synonym: "activation of retina development in camera-type eye" NARROW [GOC:TermGenie] synonym: "activation of retinal development" RELATED [GOC:TermGenie] synonym: "positive regulation of retina development in camera-style eye" EXACT [GOC:TermGenie] synonym: "positive regulation of retinal development" RELATED [GOC:TermGenie] synonym: "up regulation of retina development in camera-style eye" EXACT [GOC:TermGenie] synonym: "up regulation of retina development in camera-type eye" EXACT [GOC:TermGenie] synonym: "up regulation of retinal development" RELATED [GOC:TermGenie] synonym: "up-regulation of retina development in camera-style eye" EXACT [GOC:TermGenie] synonym: "up-regulation of retina development in camera-type eye" EXACT [GOC:TermGenie] synonym: "up-regulation of retinal development" RELATED [GOC:TermGenie] synonym: "upregulation of retina development in camera-style eye" EXACT [GOC:TermGenie] synonym: "upregulation of retina development in camera-type eye" EXACT [GOC:TermGenie] synonym: "upregulation of retinal development" RELATED [GOC:TermGenie] is_a: GO:0051094 ! positive regulation of developmental process is_a: GO:0051240 ! positive regulation of multicellular organismal process is_a: GO:1902866 ! regulation of retina development in camera-type eye intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0060041 ! positively regulates retina development in camera-type eye relationship: RO:0002213 GO:0060041 ! positively regulates retina development in camera-type eye creation_date: 2014-04-03T15:24:29Z [Term] id: GO:1902869 name: regulation of amacrine cell differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of amacrine cell differentiation." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:16872597] synonym: "regulation of amacrine neuron differentiation" EXACT [GOC:TermGenie] is_a: GO:0045664 ! regulation of neuron differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0035881 ! regulates amacrine cell differentiation relationship: RO:0002211 GO:0035881 ! regulates amacrine cell differentiation creation_date: 2014-04-03T15:24:35Z [Term] id: GO:1902870 name: negative regulation of amacrine cell differentiation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of amacrine cell differentiation." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:16872597] synonym: "down regulation of amacrine cell differentiation" EXACT [GOC:TermGenie] synonym: "down regulation of amacrine neuron differentiation" EXACT [GOC:TermGenie] synonym: "down-regulation of amacrine cell differentiation" EXACT [GOC:TermGenie] synonym: "down-regulation of amacrine neuron differentiation" EXACT [GOC:TermGenie] synonym: "downregulation of amacrine cell differentiation" EXACT [GOC:TermGenie] synonym: "downregulation of amacrine neuron differentiation" EXACT [GOC:TermGenie] synonym: "inhibition of amacrine cell differentiation" NARROW [GOC:TermGenie] synonym: "inhibition of amacrine neuron differentiation" NARROW [GOC:TermGenie] synonym: "negative regulation of amacrine neuron differentiation" EXACT [GOC:TermGenie] is_a: GO:0045665 ! negative regulation of neuron differentiation is_a: GO:1902869 ! regulation of amacrine cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0035881 ! negatively regulates amacrine cell differentiation relationship: RO:0002212 GO:0035881 ! negatively regulates amacrine cell differentiation creation_date: 2014-04-03T15:24:40Z [Term] id: GO:1902871 name: positive regulation of amacrine cell differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of amacrine cell differentiation." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:16872597] synonym: "activation of amacrine cell differentiation" NARROW [GOC:TermGenie] synonym: "activation of amacrine neuron differentiation" NARROW [GOC:TermGenie] synonym: "positive regulation of amacrine neuron differentiation" EXACT [GOC:TermGenie] synonym: "up regulation of amacrine cell differentiation" EXACT [GOC:TermGenie] synonym: "up regulation of amacrine neuron differentiation" EXACT [GOC:TermGenie] synonym: "up-regulation of amacrine cell differentiation" EXACT [GOC:TermGenie] synonym: "up-regulation of amacrine neuron differentiation" EXACT [GOC:TermGenie] synonym: "upregulation of amacrine cell differentiation" EXACT [GOC:TermGenie] synonym: "upregulation of amacrine neuron differentiation" EXACT [GOC:TermGenie] is_a: GO:0045666 ! positive regulation of neuron differentiation is_a: GO:1902869 ! regulation of amacrine cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0035881 ! positively regulates amacrine cell differentiation relationship: RO:0002213 GO:0035881 ! positively regulates amacrine cell differentiation creation_date: 2014-04-03T15:24:46Z [Term] id: GO:1902875 name: regulation of embryonic pattern specification namespace: biological_process def: "Any process that modulates the frequency, rate or extent of embryonic pattern specification." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:16872597] synonym: "regulation of embryonic pattern biosynthesis" BROAD [GOC:TermGenie] synonym: "regulation of embryonic pattern formation" BROAD [GOC:TermGenie] synonym: "regulation of ventral/lateral system" RELATED [GOC:TermGenie] is_a: GO:0051239 ! regulation of multicellular organismal process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0009880 ! regulates embryonic pattern specification relationship: RO:0002211 GO:0009880 ! regulates embryonic pattern specification property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 creation_date: 2014-04-03T15:25:15Z [Term] id: GO:1902876 name: negative regulation of embryonic pattern specification namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of embryonic pattern specification." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:16872597] synonym: "down regulation of embryonic pattern specification" EXACT [GOC:TermGenie] synonym: "down regulation of ventral/lateral system" RELATED [GOC:TermGenie] synonym: "down-regulation of embryonic pattern specification" EXACT [GOC:TermGenie] synonym: "down-regulation of ventral/lateral system" RELATED [GOC:TermGenie] synonym: "downregulation of embryonic pattern specification" EXACT [GOC:TermGenie] synonym: "downregulation of ventral/lateral system" RELATED [GOC:TermGenie] synonym: "inhibition of embryonic pattern specification" NARROW [GOC:TermGenie] synonym: "inhibition of ventral/lateral system" RELATED [GOC:TermGenie] synonym: "negative regulation of ventral/lateral system" RELATED [GOC:TermGenie] is_a: GO:0051241 ! negative regulation of multicellular organismal process is_a: GO:1902875 ! regulation of embryonic pattern specification intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0009880 ! negatively regulates embryonic pattern specification relationship: RO:0002212 GO:0009880 ! negatively regulates embryonic pattern specification property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 creation_date: 2014-04-03T15:25:20Z [Term] id: GO:1902877 name: positive regulation of embryonic pattern specification namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of embryonic pattern specification." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:16872597] synonym: "activation of embryonic pattern specification" NARROW [GOC:TermGenie] synonym: "activation of ventral/lateral system" RELATED [GOC:TermGenie] synonym: "positive regulation of ventral/lateral system" RELATED [GOC:TermGenie] synonym: "up regulation of embryonic pattern specification" EXACT [GOC:TermGenie] synonym: "up regulation of ventral/lateral system" RELATED [GOC:TermGenie] synonym: "up-regulation of embryonic pattern specification" EXACT [GOC:TermGenie] synonym: "up-regulation of ventral/lateral system" RELATED [GOC:TermGenie] synonym: "upregulation of embryonic pattern specification" EXACT [GOC:TermGenie] synonym: "upregulation of ventral/lateral system" RELATED [GOC:TermGenie] is_a: GO:0051240 ! positive regulation of multicellular organismal process is_a: GO:1902875 ! regulation of embryonic pattern specification intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0009880 ! positively regulates embryonic pattern specification relationship: RO:0002213 GO:0009880 ! positively regulates embryonic pattern specification property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 creation_date: 2014-04-03T15:25:26Z [Term] id: GO:1902882 name: regulation of response to oxidative stress namespace: biological_process def: "Any process that modulates the frequency, rate or extent of response to oxidative stress." [GO_REF:0000058, GOC:kmv, GOC:TermGenie, PMID:16899554] is_a: GO:0080134 ! regulation of response to stress intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0006979 ! regulates response to oxidative stress relationship: RO:0002211 GO:0006979 ! regulates response to oxidative stress creation_date: 2014-04-03T20:29:52Z [Term] id: GO:1902883 name: negative regulation of response to oxidative stress namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of response to oxidative stress." [GO_REF:0000058, GOC:kmv, GOC:TermGenie, PMID:16899554] synonym: "down regulation of response to oxidative stress" EXACT [GOC:TermGenie] synonym: "down-regulation of response to oxidative stress" EXACT [GOC:TermGenie] synonym: "downregulation of response to oxidative stress" EXACT [GOC:TermGenie] synonym: "inhibition of response to oxidative stress" NARROW [GOC:TermGenie] is_a: GO:0048585 ! negative regulation of response to stimulus is_a: GO:1902882 ! regulation of response to oxidative stress intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0006979 ! negatively regulates response to oxidative stress relationship: RO:0002212 GO:0006979 ! negatively regulates response to oxidative stress creation_date: 2014-04-03T20:30:20Z [Term] id: GO:1902884 name: positive regulation of response to oxidative stress namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of response to oxidative stress." [GO_REF:0000058, GOC:kmv, GOC:TermGenie, PMID:16899554] synonym: "activation of response to oxidative stress" NARROW [GOC:TermGenie] synonym: "up regulation of response to oxidative stress" EXACT [GOC:TermGenie] synonym: "up-regulation of response to oxidative stress" EXACT [GOC:TermGenie] synonym: "upregulation of response to oxidative stress" EXACT [GOC:TermGenie] is_a: GO:0048584 ! positive regulation of response to stimulus is_a: GO:1902882 ! regulation of response to oxidative stress intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0006979 ! positively regulates response to oxidative stress relationship: RO:0002213 GO:0006979 ! positively regulates response to oxidative stress creation_date: 2014-04-03T20:30:47Z [Term] id: GO:1902903 name: regulation of supramolecular fiber organization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of supramolecular fiber organization." [GO_REF:0000058, GOC:PARL, GOC:rl, GOC:TermGenie, PMID:23921388] comment: HSPA8, human, P11142 in PMID:23921388 inferred from direct assay to negatively regulate fibrillation of alpha-Syn in vitro synonym: "regulation of fibril organisation" RELATED [GOC:TermGenie] is_a: GO:0051128 ! regulation of cellular component organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0097435 ! regulates supramolecular fiber organization relationship: RO:0002211 GO:0097435 ! regulates supramolecular fiber organization creation_date: 2014-04-15T16:46:36Z [Term] id: GO:1902904 name: negative regulation of supramolecular fiber organization namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of fibril organization." [GO_REF:0000058, GOC:PARL, GOC:rl, GOC:TermGenie, PMID:23921388] comment: HSPA8, human, P11142 in PMID:23921388 inferred from direct assay to negatively regulate fibrillation of alpha-Syn in vitro synonym: "down regulation of fibril organisation" RELATED [GOC:TermGenie] synonym: "down regulation of fibril organization" RELATED [GOC:TermGenie] synonym: "down-regulation of fibril organisation" RELATED [GOC:TermGenie] synonym: "down-regulation of fibril organization" RELATED [GOC:TermGenie] synonym: "downregulation of fibril organisation" RELATED [GOC:TermGenie] synonym: "downregulation of fibril organization" RELATED [GOC:TermGenie] synonym: "inhibition of fibril organisation" NARROW [GOC:TermGenie] synonym: "inhibition of fibril organization" NARROW [GOC:TermGenie] synonym: "negative regulation of fibril organisation" RELATED [GOC:TermGenie] is_a: GO:0051129 ! negative regulation of cellular component organization is_a: GO:1902903 ! regulation of supramolecular fiber organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0097435 ! negatively regulates supramolecular fiber organization relationship: RO:0002212 GO:0097435 ! negatively regulates supramolecular fiber organization creation_date: 2014-04-15T16:46:42Z [Term] id: GO:1902905 name: positive regulation of supramolecular fiber organization namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of supramolecular fiber organization." [GO_REF:0000058, GOC:PARL, GOC:rl, GOC:TermGenie, PMID:23921388] comment: HSPA8, human, P11142 in PMID:23921388 inferred from direct assay to negatively regulate fibrillation of alpha-Syn in vitro synonym: "activation of fibril organisation" NARROW [GOC:TermGenie] synonym: "activation of fibril organization" NARROW [GOC:TermGenie] synonym: "positive regulation of fibril organisation" RELATED [GOC:TermGenie] synonym: "up regulation of fibril organisation" RELATED [GOC:TermGenie] synonym: "up regulation of fibril organization" RELATED [GOC:TermGenie] synonym: "up-regulation of fibril organisation" RELATED [GOC:TermGenie] synonym: "up-regulation of fibril organization" RELATED [GOC:TermGenie] synonym: "upregulation of fibril organisation" RELATED [GOC:TermGenie] synonym: "upregulation of fibril organization" RELATED [GOC:TermGenie] is_a: GO:0051130 ! positive regulation of cellular component organization is_a: GO:1902903 ! regulation of supramolecular fiber organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0097435 ! positively regulates supramolecular fiber organization relationship: RO:0002213 GO:0097435 ! positively regulates supramolecular fiber organization creation_date: 2014-04-15T16:46:48Z [Term] id: GO:1902908 name: regulation of melanosome transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of melanosome transport." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:23334344] is_a: GO:0050794 ! regulation of cellular process is_a: GO:0051049 ! regulation of transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0032402 ! regulates melanosome transport relationship: RO:0002211 GO:0032402 ! regulates melanosome transport creation_date: 2014-04-17T11:40:16Z [Term] id: GO:1902909 name: negative regulation of melanosome transport namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of melanosome transport." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:23334344] synonym: "down regulation of melanosome transport" EXACT [GOC:TermGenie] synonym: "down-regulation of melanosome transport" EXACT [GOC:TermGenie] synonym: "downregulation of melanosome transport" EXACT [GOC:TermGenie] synonym: "inhibition of melanosome transport" NARROW [GOC:TermGenie] is_a: GO:0048523 ! negative regulation of cellular process is_a: GO:0051051 ! negative regulation of transport is_a: GO:1902908 ! regulation of melanosome transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0032402 ! negatively regulates melanosome transport relationship: RO:0002212 GO:0032402 ! negatively regulates melanosome transport creation_date: 2014-04-17T11:40:28Z [Term] id: GO:1902910 name: positive regulation of melanosome transport namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of melanosome transport." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:23334344] synonym: "activation of melanosome transport" NARROW [GOC:TermGenie] synonym: "up regulation of melanosome transport" EXACT [GOC:TermGenie] synonym: "up-regulation of melanosome transport" EXACT [GOC:TermGenie] synonym: "upregulation of melanosome transport" EXACT [GOC:TermGenie] is_a: GO:0048522 ! positive regulation of cellular process is_a: GO:0051050 ! positive regulation of transport is_a: GO:1902908 ! regulation of melanosome transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0032402 ! positively regulates melanosome transport relationship: RO:0002213 GO:0032402 ! positively regulates melanosome transport creation_date: 2014-04-17T11:40:34Z [Term] id: GO:1902911 name: protein kinase complex namespace: cellular_component def: "A protein complex which is capable of protein kinase activity." [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:24606918] comment: An example of this is PKM2 in human (P14618) in PMID:24606918 (inferred from direct assay). is_a: GO:0061695 ! transferase complex, transferring phosphorus-containing groups intersection_of: GO:0032991 ! protein-containing complex intersection_of: RO:0002215 GO:0004672 ! capable of protein kinase activity relationship: RO:0002215 GO:0004672 ! capable of protein kinase activity creation_date: 2014-04-17T13:52:40Z [Term] id: GO:1902913 name: positive regulation of neuroepithelial cell differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of neuroepithelial cell differentiation." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:16916506] synonym: "activation of neuroepithelial cell differentiation" NARROW [GOC:TermGenie] synonym: "up regulation of neuroepithelial cell differentiation" EXACT [GOC:TermGenie] synonym: "up-regulation of neuroepithelial cell differentiation" EXACT [GOC:TermGenie] synonym: "upregulation of neuroepithelial cell differentiation" EXACT [GOC:TermGenie] is_a: GO:0030858 ! positive regulation of epithelial cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0060563 ! positively regulates neuroepithelial cell differentiation relationship: RO:0002213 GO:0060563 ! positively regulates neuroepithelial cell differentiation creation_date: 2014-04-18T21:06:42Z [Term] id: GO:1902930 name: regulation of alcohol biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of alcohol biosynthetic process." [GO_REF:0000058, GOC:mengo_curators, GOC:TermGenie, PMID:23332010] synonym: "regulation of alcohol anabolism" EXACT [GOC:TermGenie] synonym: "regulation of alcohol biosynthesis" EXACT [GOC:TermGenie] synonym: "regulation of alcohol formation" EXACT [GOC:TermGenie] synonym: "regulation of alcohol synthesis" EXACT [GOC:TermGenie] synonym: "regulation of solventogenesis" BROAD [] is_a: GO:0009889 ! regulation of biosynthetic process is_a: GO:0062012 ! regulation of small molecule metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0046165 ! regulates alcohol biosynthetic process relationship: RO:0002211 GO:0046165 ! regulates alcohol biosynthetic process creation_date: 2014-04-22T21:55:03Z [Term] id: GO:1902931 name: negative regulation of alcohol biosynthetic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of alcohol biosynthetic process." [GO_REF:0000058, GOC:mengo_curators, GOC:TermGenie, PMID:23332010] synonym: "down regulation of alcohol anabolism" EXACT [GOC:TermGenie] synonym: "down regulation of alcohol biosynthesis" EXACT [GOC:TermGenie] synonym: "down regulation of alcohol biosynthetic process" EXACT [GOC:TermGenie] synonym: "down regulation of alcohol formation" EXACT [GOC:TermGenie] synonym: "down regulation of alcohol synthesis" EXACT [GOC:TermGenie] synonym: "down-regulation of alcohol anabolism" EXACT [GOC:TermGenie] synonym: "down-regulation of alcohol biosynthesis" EXACT [GOC:TermGenie] synonym: "down-regulation of alcohol biosynthetic process" EXACT [GOC:TermGenie] synonym: "down-regulation of alcohol formation" EXACT [GOC:TermGenie] synonym: "down-regulation of alcohol synthesis" EXACT [GOC:TermGenie] synonym: "downregulation of alcohol anabolism" EXACT [GOC:TermGenie] synonym: "downregulation of alcohol biosynthesis" EXACT [GOC:TermGenie] synonym: "downregulation of alcohol biosynthetic process" EXACT [GOC:TermGenie] synonym: "downregulation of alcohol formation" EXACT [GOC:TermGenie] synonym: "downregulation of alcohol synthesis" EXACT [GOC:TermGenie] synonym: "inhibition of alcohol anabolism" NARROW [GOC:TermGenie] synonym: "inhibition of alcohol biosynthesis" NARROW [GOC:TermGenie] synonym: "inhibition of alcohol biosynthetic process" NARROW [GOC:TermGenie] synonym: "inhibition of alcohol formation" NARROW [GOC:TermGenie] synonym: "inhibition of alcohol synthesis" NARROW [GOC:TermGenie] synonym: "negative regulation of alcohol anabolism" EXACT [GOC:TermGenie] synonym: "negative regulation of alcohol biosynthesis" EXACT [GOC:TermGenie] synonym: "negative regulation of alcohol formation" EXACT [GOC:TermGenie] synonym: "negative regulation of alcohol synthesis" EXACT [GOC:TermGenie] synonym: "negative regulation of solventogenesis" BROAD [] is_a: GO:0009890 ! negative regulation of biosynthetic process is_a: GO:0062014 ! negative regulation of small molecule metabolic process is_a: GO:1902930 ! regulation of alcohol biosynthetic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0046165 ! negatively regulates alcohol biosynthetic process relationship: RO:0002212 GO:0046165 ! negatively regulates alcohol biosynthetic process creation_date: 2014-04-22T21:55:13Z [Term] id: GO:1902932 name: positive regulation of alcohol biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of alcohol biosynthetic process." [GO_REF:0000058, GOC:mengo_curators, GOC:TermGenie, PMID:23332010] synonym: "activation of alcohol anabolism" NARROW [GOC:TermGenie] synonym: "activation of alcohol biosynthesis" NARROW [GOC:TermGenie] synonym: "activation of alcohol biosynthetic process" NARROW [GOC:TermGenie] synonym: "activation of alcohol formation" NARROW [GOC:TermGenie] synonym: "activation of alcohol synthesis" NARROW [GOC:TermGenie] synonym: "positive regulation of alcohol anabolism" EXACT [GOC:TermGenie] synonym: "positive regulation of alcohol biosynthesis" EXACT [GOC:TermGenie] synonym: "positive regulation of alcohol formation" EXACT [GOC:TermGenie] synonym: "positive regulation of alcohol synthesis" EXACT [GOC:TermGenie] synonym: "positive regulation of solventogenesis" BROAD [] synonym: "up regulation of alcohol anabolism" EXACT [GOC:TermGenie] synonym: "up regulation of alcohol biosynthesis" EXACT [GOC:TermGenie] synonym: "up regulation of alcohol biosynthetic process" EXACT [GOC:TermGenie] synonym: "up regulation of alcohol formation" EXACT [GOC:TermGenie] synonym: "up regulation of alcohol synthesis" EXACT [GOC:TermGenie] synonym: "up-regulation of alcohol anabolism" EXACT [GOC:TermGenie] synonym: "up-regulation of alcohol biosynthesis" EXACT [GOC:TermGenie] synonym: "up-regulation of alcohol biosynthetic process" EXACT [GOC:TermGenie] synonym: "up-regulation of alcohol formation" EXACT [GOC:TermGenie] synonym: "up-regulation of alcohol synthesis" EXACT [GOC:TermGenie] synonym: "upregulation of alcohol anabolism" EXACT [GOC:TermGenie] synonym: "upregulation of alcohol biosynthesis" EXACT [GOC:TermGenie] synonym: "upregulation of alcohol biosynthetic process" EXACT [GOC:TermGenie] synonym: "upregulation of alcohol formation" EXACT [GOC:TermGenie] synonym: "upregulation of alcohol synthesis" EXACT [GOC:TermGenie] is_a: GO:0009891 ! positive regulation of biosynthetic process is_a: GO:0062013 ! positive regulation of small molecule metabolic process is_a: GO:1902930 ! regulation of alcohol biosynthetic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0046165 ! positively regulates alcohol biosynthetic process relationship: RO:0002213 GO:0046165 ! positively regulates alcohol biosynthetic process creation_date: 2014-04-22T21:55:19Z [Term] id: GO:1903000 name: regulation of lipid transport across blood-brain barrier namespace: biological_process def: "Any process that modulates the frequency, rate or extent of lipid transport across blood-brain barrier." [GO_REF:0000058, GOC:sjp, GOC:TermGenie, PMID:24345162] synonym: "regulation of lipid transport across blood brain barrier" EXACT [] is_a: GO:0032368 ! regulation of lipid transport is_a: GO:0150200 ! regulation of transport across blood-brain barrier intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:1990379 ! regulates lipid transport across blood-brain barrier relationship: RO:0002211 GO:1990379 ! regulates lipid transport across blood-brain barrier creation_date: 2014-05-09T09:30:04Z [Term] id: GO:1903001 name: negative regulation of lipid transport across blood-brain barrier namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of lipid transport across blood-brain barrier." [GO_REF:0000058, GOC:sjp, GOC:TermGenie, PMID:24345162] synonym: "down regulation of lipid transport across blood brain barrier" EXACT [GOC:TermGenie] synonym: "down-regulation of lipid transport across blood brain barrier" EXACT [GOC:TermGenie] synonym: "downregulation of lipid transport across blood brain barrier" EXACT [GOC:TermGenie] synonym: "inhibition of lipid transport across blood brain barrier" NARROW [GOC:TermGenie] synonym: "negative regulation of lipid transport across blood brain barrier" EXACT [] is_a: GO:0032369 ! negative regulation of lipid transport is_a: GO:0150202 ! negative regulation of transport across blood-brain barrier is_a: GO:1903000 ! regulation of lipid transport across blood-brain barrier intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:1990379 ! negatively regulates lipid transport across blood-brain barrier relationship: RO:0002212 GO:1990379 ! negatively regulates lipid transport across blood-brain barrier creation_date: 2014-05-09T09:30:10Z [Term] id: GO:1903002 name: positive regulation of lipid transport across blood-brain barrier namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of lipid transport across blood-brain barrier." [GO_REF:0000058, GOC:sjp, GOC:TermGenie, PMID:24345162] synonym: "activation of lipid transport across blood brain barrier" NARROW [GOC:TermGenie] synonym: "positive regulation of lipid transport across blood brain barrier" EXACT [] synonym: "up regulation of lipid transport across blood brain barrier" EXACT [GOC:TermGenie] synonym: "up-regulation of lipid transport across blood brain barrier" EXACT [GOC:TermGenie] synonym: "upregulation of lipid transport across blood brain barrier" EXACT [GOC:TermGenie] is_a: GO:0032370 ! positive regulation of lipid transport is_a: GO:0150201 ! positive regulation of transport across blood-brain barrier is_a: GO:1903000 ! regulation of lipid transport across blood-brain barrier intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:1990379 ! positively regulates lipid transport across blood-brain barrier relationship: RO:0002213 GO:1990379 ! positively regulates lipid transport across blood-brain barrier creation_date: 2014-05-09T09:30:16Z [Term] id: GO:1903008 name: organelle disassembly namespace: biological_process def: "The disaggregation of an organelle into its constituent components." [GO_REF:0000079, GOC:TermGenie] synonym: "organelle degradation" EXACT [] is_a: GO:0006996 ! organelle organization is_a: GO:0022411 ! cellular component disassembly intersection_of: GO:0022411 ! cellular component disassembly intersection_of: RO:0002590 GO:0043226 ! results in disassembly of organelle relationship: RO:0002590 GO:0043226 ! results in disassembly of organelle creation_date: 2014-05-13T12:36:03Z [Term] id: GO:1903010 name: regulation of bone development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of bone development." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:22510437] is_a: GO:2000026 ! regulation of multicellular organismal development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0060348 ! regulates bone development relationship: RO:0002211 GO:0060348 ! regulates bone development creation_date: 2014-05-13T22:41:53Z [Term] id: GO:1903011 name: negative regulation of bone development namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of bone development." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:22510437] synonym: "down regulation of bone development" EXACT [GOC:TermGenie] synonym: "down-regulation of bone development" EXACT [GOC:TermGenie] synonym: "downregulation of bone development" EXACT [GOC:TermGenie] synonym: "inhibition of bone development" NARROW [GOC:TermGenie] is_a: GO:0051093 ! negative regulation of developmental process is_a: GO:0051241 ! negative regulation of multicellular organismal process is_a: GO:1903010 ! regulation of bone development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0060348 ! negatively regulates bone development relationship: RO:0002212 GO:0060348 ! negatively regulates bone development creation_date: 2014-05-13T22:42:00Z [Term] id: GO:1903012 name: positive regulation of bone development namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of bone development." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:22510437] synonym: "activation of bone development" NARROW [GOC:TermGenie] synonym: "up regulation of bone development" EXACT [GOC:TermGenie] synonym: "up-regulation of bone development" EXACT [GOC:TermGenie] synonym: "upregulation of bone development" EXACT [GOC:TermGenie] is_a: GO:0051094 ! positive regulation of developmental process is_a: GO:0051240 ! positive regulation of multicellular organismal process is_a: GO:1903010 ! regulation of bone development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0060348 ! positively regulates bone development relationship: RO:0002213 GO:0060348 ! positively regulates bone development creation_date: 2014-05-13T22:42:06Z [Term] id: GO:1903018 name: regulation of glycoprotein metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of glycoprotein metabolic process." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:23544079] comment: human serum amyloid P component (SAP) P02743 inhibits viral neuraminidase, NA (exo-alpha-sialidase activity) and thus the metabolism of glycoproteins, demonstrated in Figure 4A PMID:23544079, (IDA), the negative regulation term would be applied to this protein synonym: "regulation of glycoprotein metabolism" EXACT [GOC:TermGenie] is_a: GO:0051246 ! regulation of protein metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0009100 ! regulates glycoprotein metabolic process relationship: RO:0002211 GO:0009100 ! regulates glycoprotein metabolic process creation_date: 2014-05-14T18:44:19Z [Term] id: GO:1903019 name: negative regulation of glycoprotein metabolic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of glycoprotein metabolic process." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:23544079] comment: human serum amyloid P component (SAP) P02743 inhibits viral neuraminidase, NA (exo-alpha-sialidase activity) and thus the metabolism of glycoproteins, demonstrated in Figure 4A PMID:23544079, (IDA), the negative regulation term would be applied to this protein synonym: "down regulation of glycoprotein metabolic process" EXACT [GOC:TermGenie] synonym: "down regulation of glycoprotein metabolism" EXACT [GOC:TermGenie] synonym: "down-regulation of glycoprotein metabolic process" EXACT [GOC:TermGenie] synonym: "down-regulation of glycoprotein metabolism" EXACT [GOC:TermGenie] synonym: "downregulation of glycoprotein metabolic process" EXACT [GOC:TermGenie] synonym: "downregulation of glycoprotein metabolism" EXACT [GOC:TermGenie] synonym: "inhibition of glycoprotein metabolic process" NARROW [GOC:TermGenie] synonym: "inhibition of glycoprotein metabolism" NARROW [GOC:TermGenie] synonym: "negative regulation of glycoprotein metabolism" EXACT [GOC:TermGenie] is_a: GO:0051248 ! negative regulation of protein metabolic process is_a: GO:1903018 ! regulation of glycoprotein metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0009100 ! negatively regulates glycoprotein metabolic process relationship: RO:0002212 GO:0009100 ! negatively regulates glycoprotein metabolic process creation_date: 2014-05-14T18:44:25Z [Term] id: GO:1903020 name: positive regulation of glycoprotein metabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of glycoprotein metabolic process." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:23544079] comment: human serum amyloid P component (SAP) P02743 inhibits viral neuraminidase, NA (exo-alpha-sialidase activity) and thus the metabolism of glycoproteins, demonstrated in Figure 4A PMID:23544079, (IDA), the negative regulation term would be applied to this protein synonym: "activation of glycoprotein metabolic process" NARROW [GOC:TermGenie] synonym: "activation of glycoprotein metabolism" NARROW [GOC:TermGenie] synonym: "positive regulation of glycoprotein metabolism" EXACT [GOC:TermGenie] synonym: "up regulation of glycoprotein metabolic process" EXACT [GOC:TermGenie] synonym: "up regulation of glycoprotein metabolism" EXACT [GOC:TermGenie] synonym: "up-regulation of glycoprotein metabolic process" EXACT [GOC:TermGenie] synonym: "up-regulation of glycoprotein metabolism" EXACT [GOC:TermGenie] synonym: "upregulation of glycoprotein metabolic process" EXACT [GOC:TermGenie] synonym: "upregulation of glycoprotein metabolism" EXACT [GOC:TermGenie] is_a: GO:0051247 ! positive regulation of protein metabolic process is_a: GO:1903018 ! regulation of glycoprotein metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0009100 ! positively regulates glycoprotein metabolic process relationship: RO:0002213 GO:0009100 ! positively regulates glycoprotein metabolic process creation_date: 2014-05-14T18:44:31Z [Term] id: GO:1903034 name: regulation of response to wounding namespace: biological_process def: "Any process that modulates the frequency, rate or extent of response to wounding." [GO_REF:0000058, GOC:kmv, GOC:TermGenie, PMID:19164535] synonym: "regulation of physiological response to wounding" EXACT [GOC:TermGenie] is_a: GO:0080134 ! regulation of response to stress intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0009611 ! regulates response to wounding relationship: RO:0002211 GO:0009611 ! regulates response to wounding creation_date: 2014-05-18T01:28:46Z [Term] id: GO:1903035 name: negative regulation of response to wounding namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of response to wounding." [GO_REF:0000058, GOC:kmv, GOC:TermGenie, PMID:19164535] synonym: "down regulation of physiological response to wounding" EXACT [GOC:TermGenie] synonym: "down regulation of response to wounding" EXACT [GOC:TermGenie] synonym: "down-regulation of physiological response to wounding" EXACT [GOC:TermGenie] synonym: "down-regulation of response to wounding" EXACT [GOC:TermGenie] synonym: "downregulation of physiological response to wounding" EXACT [GOC:TermGenie] synonym: "downregulation of response to wounding" EXACT [GOC:TermGenie] synonym: "inhibition of physiological response to wounding" NARROW [GOC:TermGenie] synonym: "inhibition of response to wounding" NARROW [GOC:TermGenie] synonym: "negative regulation of physiological response to wounding" EXACT [GOC:TermGenie] is_a: GO:0048585 ! negative regulation of response to stimulus is_a: GO:1903034 ! regulation of response to wounding intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0009611 ! negatively regulates response to wounding relationship: RO:0002212 GO:0009611 ! negatively regulates response to wounding creation_date: 2014-05-18T01:28:52Z [Term] id: GO:1903036 name: positive regulation of response to wounding namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of response to wounding." [GO_REF:0000058, GOC:kmv, GOC:TermGenie, PMID:19164535] synonym: "activation of physiological response to wounding" NARROW [GOC:TermGenie] synonym: "activation of response to wounding" NARROW [GOC:TermGenie] synonym: "positive regulation of physiological response to wounding" EXACT [GOC:TermGenie] synonym: "up regulation of physiological response to wounding" EXACT [GOC:TermGenie] synonym: "up regulation of response to wounding" EXACT [GOC:TermGenie] synonym: "up-regulation of physiological response to wounding" EXACT [GOC:TermGenie] synonym: "up-regulation of response to wounding" EXACT [GOC:TermGenie] synonym: "upregulation of physiological response to wounding" EXACT [GOC:TermGenie] synonym: "upregulation of response to wounding" EXACT [GOC:TermGenie] is_a: GO:0048584 ! positive regulation of response to stimulus is_a: GO:1903034 ! regulation of response to wounding intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0009611 ! positively regulates response to wounding relationship: RO:0002213 GO:0009611 ! positively regulates response to wounding creation_date: 2014-05-18T01:28:58Z [Term] id: GO:1903037 name: regulation of leukocyte cell-cell adhesion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of leukocyte cell-cell adhesion." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:21106532] comment: Exogenous expression of ASS1 or NOS3 in HUVECs enhances NO production and inhibits monocyte adhesion synonym: "regulation of leukocyte adhesion" EXACT [GOC:TermGenie] synonym: "regulation of leukocyte cell adhesion" EXACT [GOC:TermGenie] is_a: GO:0022407 ! regulation of cell-cell adhesion intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0007159 ! regulates leukocyte cell-cell adhesion relationship: RO:0002211 GO:0007159 ! regulates leukocyte cell-cell adhesion creation_date: 2014-05-19T15:29:58Z [Term] id: GO:1903038 name: negative regulation of leukocyte cell-cell adhesion namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of leukocyte cell-cell adhesion." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:21106532] comment: Exogenous expression of ASS1 or NOS3 in HUVECs enhances NO production and inhibits monocyte adhesion synonym: "down regulation of leukocyte adhesion" EXACT [GOC:TermGenie] synonym: "down regulation of leukocyte cell adhesion" EXACT [GOC:TermGenie] synonym: "down regulation of leukocyte cell-cell adhesion" EXACT [GOC:TermGenie] synonym: "down-regulation of leukocyte adhesion" EXACT [GOC:TermGenie] synonym: "down-regulation of leukocyte cell adhesion" EXACT [GOC:TermGenie] synonym: "down-regulation of leukocyte cell-cell adhesion" EXACT [GOC:TermGenie] synonym: "downregulation of leukocyte adhesion" EXACT [GOC:TermGenie] synonym: "downregulation of leukocyte cell adhesion" EXACT [GOC:TermGenie] synonym: "downregulation of leukocyte cell-cell adhesion" EXACT [GOC:TermGenie] synonym: "inhibition of leukocyte adhesion" NARROW [GOC:TermGenie] synonym: "inhibition of leukocyte cell adhesion" NARROW [GOC:TermGenie] synonym: "inhibition of leukocyte cell-cell adhesion" NARROW [GOC:TermGenie] synonym: "negative regulation of leukocyte adhesion" EXACT [GOC:TermGenie] synonym: "negative regulation of leukocyte cell adhesion" EXACT [GOC:TermGenie] is_a: GO:0022408 ! negative regulation of cell-cell adhesion is_a: GO:1903037 ! regulation of leukocyte cell-cell adhesion intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0007159 ! negatively regulates leukocyte cell-cell adhesion relationship: RO:0002212 GO:0007159 ! negatively regulates leukocyte cell-cell adhesion creation_date: 2014-05-19T15:30:05Z [Term] id: GO:1903039 name: positive regulation of leukocyte cell-cell adhesion namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of leukocyte cell-cell adhesion." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:21106532] comment: Exogenous expression of ASS1 or NOS3 in HUVECs enhances NO production and inhibits monocyte adhesion synonym: "activation of leukocyte adhesion" NARROW [GOC:TermGenie] synonym: "activation of leukocyte cell adhesion" NARROW [GOC:TermGenie] synonym: "activation of leukocyte cell-cell adhesion" NARROW [GOC:TermGenie] synonym: "positive regulation of leukocyte adhesion" EXACT [GOC:TermGenie] synonym: "positive regulation of leukocyte cell adhesion" EXACT [GOC:TermGenie] synonym: "up regulation of leukocyte adhesion" EXACT [GOC:TermGenie] synonym: "up regulation of leukocyte cell adhesion" EXACT [GOC:TermGenie] synonym: "up regulation of leukocyte cell-cell adhesion" EXACT [GOC:TermGenie] synonym: "up-regulation of leukocyte adhesion" EXACT [GOC:TermGenie] synonym: "up-regulation of leukocyte cell adhesion" EXACT [GOC:TermGenie] synonym: "up-regulation of leukocyte cell-cell adhesion" EXACT [GOC:TermGenie] synonym: "upregulation of leukocyte adhesion" EXACT [GOC:TermGenie] synonym: "upregulation of leukocyte cell adhesion" EXACT [GOC:TermGenie] synonym: "upregulation of leukocyte cell-cell adhesion" EXACT [GOC:TermGenie] is_a: GO:0022409 ! positive regulation of cell-cell adhesion is_a: GO:1903037 ! regulation of leukocyte cell-cell adhesion intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0007159 ! positively regulates leukocyte cell-cell adhesion relationship: RO:0002213 GO:0007159 ! positively regulates leukocyte cell-cell adhesion creation_date: 2014-05-19T15:30:15Z [Term] id: GO:1903041 name: regulation of chondrocyte hypertrophy namespace: biological_process def: "Any process that modulates the frequency, rate or extent of chondrocyte hypertrophy." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:23928032] is_a: GO:0001558 ! regulation of cell growth is_a: GO:0048638 ! regulation of developmental growth is_a: GO:0061181 ! regulation of chondrocyte development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0003415 ! regulates chondrocyte hypertrophy relationship: RO:0002211 GO:0003415 ! regulates chondrocyte hypertrophy creation_date: 2014-05-20T21:23:13Z [Term] id: GO:1903042 name: negative regulation of chondrocyte hypertrophy namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of chondrocyte hypertrophy." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:23928032] synonym: "down regulation of chondrocyte hypertrophy" EXACT [GOC:TermGenie] synonym: "down-regulation of chondrocyte hypertrophy" EXACT [GOC:TermGenie] synonym: "downregulation of chondrocyte hypertrophy" EXACT [GOC:TermGenie] synonym: "inhibition of chondrocyte hypertrophy" NARROW [GOC:TermGenie] is_a: GO:0030308 ! negative regulation of cell growth is_a: GO:0048640 ! negative regulation of developmental growth is_a: GO:0061182 ! negative regulation of chondrocyte development is_a: GO:1903041 ! regulation of chondrocyte hypertrophy intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0003415 ! negatively regulates chondrocyte hypertrophy relationship: RO:0002212 GO:0003415 ! negatively regulates chondrocyte hypertrophy creation_date: 2014-05-20T21:23:19Z [Term] id: GO:1903043 name: positive regulation of chondrocyte hypertrophy namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of chondrocyte hypertrophy." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:23928032] synonym: "activation of chondrocyte hypertrophy" NARROW [GOC:TermGenie] synonym: "up regulation of chondrocyte hypertrophy" EXACT [GOC:TermGenie] synonym: "up-regulation of chondrocyte hypertrophy" EXACT [GOC:TermGenie] synonym: "upregulation of chondrocyte hypertrophy" EXACT [GOC:TermGenie] is_a: GO:0030307 ! positive regulation of cell growth is_a: GO:0048639 ! positive regulation of developmental growth is_a: GO:1902761 ! positive regulation of chondrocyte development is_a: GO:1903041 ! regulation of chondrocyte hypertrophy intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0003415 ! positively regulates chondrocyte hypertrophy relationship: RO:0002213 GO:0003415 ! positively regulates chondrocyte hypertrophy creation_date: 2014-05-20T21:23:25Z [Term] id: GO:1903045 name: neural crest cell migration involved in sympathetic nervous system development namespace: biological_process def: "Any neural crest cell migration that is involved in sympathetic nervous system development." [GO_REF:0000060, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:19325129] comment: Sema3a (O08665, mouse) is involved in neural crest cell migration involved in sympathetic nervous system development is_a: GO:1901166 ! neural crest cell migration involved in autonomic nervous system development intersection_of: GO:0001755 ! neural crest cell migration intersection_of: BFO:0000050 GO:0048485 ! part of sympathetic nervous system development relationship: BFO:0000050 GO:0048485 ! part of sympathetic nervous system development creation_date: 2014-05-22T07:06:02Z [Term] id: GO:1903046 name: meiotic cell cycle process namespace: biological_process def: "A process that is part of the meiotic cell cycle." [GO_REF:0000060, GOC:mtg_cell_cycle, GOC:TermGenie] subset: gocheck_do_not_annotate subset: goslim_pombe is_a: GO:0022402 ! cell cycle process is_a: GO:0022414 ! reproductive process intersection_of: GO:0009987 ! cellular process intersection_of: BFO:0000050 GO:0051321 ! part of meiotic cell cycle disjoint_from: GO:1903047 ! mitotic cell cycle process relationship: BFO:0000050 GO:0051321 ! part of meiotic cell cycle creation_date: 2014-05-22T14:22:28Z [Term] id: GO:1903047 name: mitotic cell cycle process namespace: biological_process def: "A process that is part of the mitotic cell cycle." [GO_REF:0000060, GOC:mtg_cell_cycle, GOC:TermGenie] subset: gocheck_do_not_annotate is_a: GO:0022402 ! cell cycle process intersection_of: GO:0009987 ! cellular process intersection_of: BFO:0000050 GO:0000278 ! part of mitotic cell cycle relationship: BFO:0000050 GO:0000278 ! part of mitotic cell cycle creation_date: 2014-05-22T14:22:34Z [Term] id: GO:1903050 name: regulation of proteolysis involved in protein catabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of proteolysis involved in cellular catabolic process." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:18307834] comment: overexpression of cathepsin C propeptide significantly increased the degradation of intestinal alkaline phosphatase (IAP) synonym: "regulation of peptidolysis during cellular protein catabolic process" RELATED [GOC:TermGenie] synonym: "regulation of peptidolysis during cellular protein catabolism" RELATED [GOC:TermGenie] synonym: "regulation of peptidolysis involved in cellular protein catabolic process" EXACT [GOC:TermGenie] synonym: "regulation of peptidolysis involved in cellular protein catabolism" EXACT [GOC:TermGenie] synonym: "regulation of proteolysis during cellular protein catabolic process" RELATED [GOC:TermGenie] synonym: "regulation of proteolysis during cellular protein catabolism" RELATED [GOC:TermGenie] synonym: "regulation of proteolysis involved in cellular protein catabolic process" EXACT [] is_a: GO:0030162 ! regulation of proteolysis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0051603 ! regulates proteolysis involved in protein catabolic process relationship: RO:0002211 GO:0051603 ! regulates proteolysis involved in protein catabolic process property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/23112" xsd:anyURI creation_date: 2014-05-22T18:00:45Z [Term] id: GO:1903051 name: negative regulation of proteolysis involved in protein catabolic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of proteolysis involved in protein catabolic process." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:18307834] comment: Overexpression of cathepsin C propeptide significantly increased the degradation of intestinal alkaline phosphatase (IAP). synonym: "down regulation of peptidolysis during cellular protein catabolic process" RELATED [GOC:TermGenie] synonym: "down regulation of peptidolysis during cellular protein catabolism" RELATED [GOC:TermGenie] synonym: "down regulation of peptidolysis involved in cellular protein catabolic process" EXACT [GOC:TermGenie] synonym: "down regulation of peptidolysis involved in cellular protein catabolism" EXACT [GOC:TermGenie] synonym: "down regulation of proteolysis during cellular protein catabolic process" RELATED [GOC:TermGenie] synonym: "down regulation of proteolysis during cellular protein catabolism" RELATED [GOC:TermGenie] synonym: "down regulation of proteolysis involved in cellular protein catabolic process" EXACT [GOC:TermGenie] synonym: "down-regulation of peptidolysis during cellular protein catabolic process" RELATED [GOC:TermGenie] synonym: "down-regulation of peptidolysis during cellular protein catabolism" RELATED [GOC:TermGenie] synonym: "down-regulation of peptidolysis involved in cellular protein catabolic process" EXACT [GOC:TermGenie] synonym: "down-regulation of peptidolysis involved in cellular protein catabolism" EXACT [GOC:TermGenie] synonym: "down-regulation of proteolysis during cellular protein catabolic process" RELATED [GOC:TermGenie] synonym: "down-regulation of proteolysis during cellular protein catabolism" RELATED [GOC:TermGenie] synonym: "down-regulation of proteolysis involved in cellular protein catabolic process" EXACT [GOC:TermGenie] synonym: "downregulation of peptidolysis during cellular protein catabolic process" RELATED [GOC:TermGenie] synonym: "downregulation of peptidolysis during cellular protein catabolism" RELATED [GOC:TermGenie] synonym: "downregulation of peptidolysis involved in cellular protein catabolic process" EXACT [GOC:TermGenie] synonym: "downregulation of peptidolysis involved in cellular protein catabolism" EXACT [GOC:TermGenie] synonym: "downregulation of proteolysis during cellular protein catabolic process" RELATED [GOC:TermGenie] synonym: "downregulation of proteolysis during cellular protein catabolism" RELATED [GOC:TermGenie] synonym: "downregulation of proteolysis involved in cellular protein catabolic process" EXACT [GOC:TermGenie] synonym: "inhibition of peptidolysis during cellular protein catabolic process" RELATED [GOC:TermGenie] synonym: "inhibition of peptidolysis during cellular protein catabolism" RELATED [GOC:TermGenie] synonym: "inhibition of peptidolysis involved in cellular protein catabolic process" NARROW [GOC:TermGenie] synonym: "inhibition of peptidolysis involved in cellular protein catabolism" NARROW [GOC:TermGenie] synonym: "inhibition of proteolysis during cellular protein catabolic process" RELATED [GOC:TermGenie] synonym: "inhibition of proteolysis during cellular protein catabolism" RELATED [GOC:TermGenie] synonym: "inhibition of proteolysis involved in cellular protein catabolic process" NARROW [GOC:TermGenie] synonym: "negative regulation of peptidolysis during cellular protein catabolic process" RELATED [GOC:TermGenie] synonym: "negative regulation of peptidolysis during cellular protein catabolism" RELATED [GOC:TermGenie] synonym: "negative regulation of peptidolysis involved in cellular protein catabolic process" EXACT [GOC:TermGenie] synonym: "negative regulation of peptidolysis involved in cellular protein catabolism" EXACT [GOC:TermGenie] synonym: "negative regulation of proteolysis during cellular protein catabolic process" RELATED [GOC:TermGenie] synonym: "negative regulation of proteolysis during cellular protein catabolism" RELATED [GOC:TermGenie] synonym: "negative regulation of proteolysis involved in cellular protein catabolic process" EXACT [] is_a: GO:0045861 ! negative regulation of proteolysis is_a: GO:1903050 ! regulation of proteolysis involved in protein catabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0051603 ! negatively regulates proteolysis involved in protein catabolic process relationship: RO:0002212 GO:0051603 ! negatively regulates proteolysis involved in protein catabolic process property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/23112" xsd:anyURI creation_date: 2014-05-22T18:00:51Z [Term] id: GO:1903052 name: positive regulation of proteolysis involved in protein catabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of proteolysis involved in protein catabolic process." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:18307834] comment: overexpression of cathepsin C propeptide significantly increased the degradation of intestinal alkaline phosphatase (IAP) synonym: "activation of peptidolysis during cellular protein catabolic process" RELATED [GOC:TermGenie] synonym: "activation of peptidolysis during cellular protein catabolism" RELATED [GOC:TermGenie] synonym: "activation of peptidolysis involved in cellular protein catabolic process" NARROW [GOC:TermGenie] synonym: "activation of peptidolysis involved in cellular protein catabolism" NARROW [GOC:TermGenie] synonym: "activation of proteolysis during cellular protein catabolic process" RELATED [GOC:TermGenie] synonym: "activation of proteolysis during cellular protein catabolism" RELATED [GOC:TermGenie] synonym: "activation of proteolysis involved in cellular protein catabolic process" NARROW [GOC:TermGenie] synonym: "positive regulation of peptidolysis during cellular protein catabolic process" RELATED [GOC:TermGenie] synonym: "positive regulation of peptidolysis during cellular protein catabolism" RELATED [GOC:TermGenie] synonym: "positive regulation of peptidolysis involved in cellular protein catabolic process" EXACT [GOC:TermGenie] synonym: "positive regulation of peptidolysis involved in cellular protein catabolism" EXACT [GOC:TermGenie] synonym: "positive regulation of proteolysis during cellular protein catabolic process" RELATED [GOC:TermGenie] synonym: "positive regulation of proteolysis during cellular protein catabolism" RELATED [GOC:TermGenie] synonym: "positive regulation of proteolysis involved in cellular protein catabolic process" EXACT [] synonym: "up regulation of peptidolysis during cellular protein catabolic process" RELATED [GOC:TermGenie] synonym: "up regulation of peptidolysis during cellular protein catabolism" RELATED [GOC:TermGenie] synonym: "up regulation of peptidolysis involved in cellular protein catabolic process" EXACT [GOC:TermGenie] synonym: "up regulation of peptidolysis involved in cellular protein catabolism" EXACT [GOC:TermGenie] synonym: "up regulation of proteolysis during cellular protein catabolic process" RELATED [GOC:TermGenie] synonym: "up regulation of proteolysis during cellular protein catabolism" RELATED [GOC:TermGenie] synonym: "up regulation of proteolysis involved in cellular protein catabolic process" EXACT [GOC:TermGenie] synonym: "up-regulation of peptidolysis during cellular protein catabolic process" RELATED [GOC:TermGenie] synonym: "up-regulation of peptidolysis during cellular protein catabolism" RELATED [GOC:TermGenie] synonym: "up-regulation of peptidolysis involved in cellular protein catabolic process" EXACT [GOC:TermGenie] synonym: "up-regulation of peptidolysis involved in cellular protein catabolism" EXACT [GOC:TermGenie] synonym: "up-regulation of proteolysis during cellular protein catabolic process" RELATED [GOC:TermGenie] synonym: "up-regulation of proteolysis during cellular protein catabolism" RELATED [GOC:TermGenie] synonym: "up-regulation of proteolysis involved in cellular protein catabolic process" EXACT [GOC:TermGenie] synonym: "upregulation of peptidolysis during cellular protein catabolic process" RELATED [GOC:TermGenie] synonym: "upregulation of peptidolysis during cellular protein catabolism" RELATED [GOC:TermGenie] synonym: "upregulation of peptidolysis involved in cellular protein catabolic process" EXACT [GOC:TermGenie] synonym: "upregulation of peptidolysis involved in cellular protein catabolism" EXACT [GOC:TermGenie] synonym: "upregulation of proteolysis during cellular protein catabolic process" RELATED [GOC:TermGenie] synonym: "upregulation of proteolysis during cellular protein catabolism" RELATED [GOC:TermGenie] synonym: "upregulation of proteolysis involved in cellular protein catabolic process" EXACT [GOC:TermGenie] is_a: GO:0045862 ! positive regulation of proteolysis is_a: GO:1903050 ! regulation of proteolysis involved in protein catabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0051603 ! positively regulates proteolysis involved in protein catabolic process relationship: RO:0002213 GO:0051603 ! positively regulates proteolysis involved in protein catabolic process property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/23112" xsd:anyURI creation_date: 2014-05-22T18:00:57Z [Term] id: GO:1903053 name: regulation of extracellular matrix organization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of extracellular matrix organization." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:22357537] synonym: "regulation of extracellular matrix organisation" EXACT [GOC:TermGenie] synonym: "regulation of extracellular matrix organization and biogenesis" RELATED [GOC:TermGenie] is_a: GO:0051128 ! regulation of cellular component organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0030198 ! regulates extracellular matrix organization relationship: RO:0002211 GO:0030198 ! regulates extracellular matrix organization creation_date: 2014-05-23T17:15:41Z [Term] id: GO:1903054 name: negative regulation of extracellular matrix organization namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of extracellular matrix organization." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:22357537] synonym: "down regulation of extracellular matrix organisation" EXACT [GOC:TermGenie] synonym: "down regulation of extracellular matrix organization" EXACT [GOC:TermGenie] synonym: "down regulation of extracellular matrix organization and biogenesis" RELATED [GOC:TermGenie] synonym: "down-regulation of extracellular matrix organisation" EXACT [GOC:TermGenie] synonym: "down-regulation of extracellular matrix organization" EXACT [GOC:TermGenie] synonym: "down-regulation of extracellular matrix organization and biogenesis" RELATED [GOC:TermGenie] synonym: "downregulation of extracellular matrix organisation" EXACT [GOC:TermGenie] synonym: "downregulation of extracellular matrix organization" EXACT [GOC:TermGenie] synonym: "downregulation of extracellular matrix organization and biogenesis" RELATED [GOC:TermGenie] synonym: "inhibition of extracellular matrix organisation" NARROW [GOC:TermGenie] synonym: "inhibition of extracellular matrix organization" NARROW [GOC:TermGenie] synonym: "inhibition of extracellular matrix organization and biogenesis" RELATED [GOC:TermGenie] synonym: "negative regulation of extracellular matrix organisation" EXACT [GOC:TermGenie] synonym: "negative regulation of extracellular matrix organization and biogenesis" RELATED [GOC:TermGenie] is_a: GO:0051129 ! negative regulation of cellular component organization is_a: GO:1903053 ! regulation of extracellular matrix organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0030198 ! negatively regulates extracellular matrix organization relationship: RO:0002212 GO:0030198 ! negatively regulates extracellular matrix organization creation_date: 2014-05-23T17:15:47Z [Term] id: GO:1903055 name: positive regulation of extracellular matrix organization namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of extracellular matrix organization." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:22357537] synonym: "activation of extracellular matrix organisation" NARROW [GOC:TermGenie] synonym: "activation of extracellular matrix organization" NARROW [GOC:TermGenie] synonym: "activation of extracellular matrix organization and biogenesis" RELATED [GOC:TermGenie] synonym: "positive regulation of extracellular matrix organisation" EXACT [GOC:TermGenie] synonym: "positive regulation of extracellular matrix organization and biogenesis" RELATED [GOC:TermGenie] synonym: "up regulation of extracellular matrix organisation" EXACT [GOC:TermGenie] synonym: "up regulation of extracellular matrix organization" EXACT [GOC:TermGenie] synonym: "up regulation of extracellular matrix organization and biogenesis" RELATED [GOC:TermGenie] synonym: "up-regulation of extracellular matrix organisation" EXACT [GOC:TermGenie] synonym: "up-regulation of extracellular matrix organization" EXACT [GOC:TermGenie] synonym: "up-regulation of extracellular matrix organization and biogenesis" RELATED [GOC:TermGenie] synonym: "upregulation of extracellular matrix organisation" EXACT [GOC:TermGenie] synonym: "upregulation of extracellular matrix organization" EXACT [GOC:TermGenie] synonym: "upregulation of extracellular matrix organization and biogenesis" RELATED [GOC:TermGenie] is_a: GO:0051130 ! positive regulation of cellular component organization is_a: GO:1903053 ! regulation of extracellular matrix organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0030198 ! positively regulates extracellular matrix organization relationship: RO:0002213 GO:0030198 ! positively regulates extracellular matrix organization creation_date: 2014-05-23T17:15:53Z [Term] id: GO:1903056 name: regulation of melanosome organization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of melanosome organization." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:24769727] comment: Lack of the transcription factor Zeb2 Q9R0G7 leads to spherical melanosomes with irregular borders, in contrast to the rod-shaped melanosomes of ZEB2MCWT hair follicles synonym: "regulation of melanosome organisation" EXACT [GOC:TermGenie] synonym: "regulation of melanosome organization and biogenesis" RELATED [GOC:TermGenie] is_a: GO:0033043 ! regulation of organelle organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0032438 ! regulates melanosome organization relationship: RO:0002211 GO:0032438 ! regulates melanosome organization creation_date: 2014-05-27T13:27:49Z [Term] id: GO:1903057 name: negative regulation of melanosome organization namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of melanosome organization." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:24769727] comment: Lack of the transcription factor Zeb2 Q9R0G7 leads to spherical melanosomes with irregular borders, in contrast to the rod-shaped melanosomes of ZEB2MCWT hair follicles. synonym: "down regulation of melanosome organisation" EXACT [GOC:TermGenie] synonym: "down regulation of melanosome organization" EXACT [GOC:TermGenie] synonym: "down regulation of melanosome organization and biogenesis" RELATED [GOC:TermGenie] synonym: "down-regulation of melanosome organisation" EXACT [GOC:TermGenie] synonym: "down-regulation of melanosome organization" EXACT [GOC:TermGenie] synonym: "down-regulation of melanosome organization and biogenesis" RELATED [GOC:TermGenie] synonym: "downregulation of melanosome organisation" EXACT [GOC:TermGenie] synonym: "downregulation of melanosome organization" EXACT [GOC:TermGenie] synonym: "downregulation of melanosome organization and biogenesis" RELATED [GOC:TermGenie] synonym: "inhibition of melanosome organisation" NARROW [GOC:TermGenie] synonym: "inhibition of melanosome organization" NARROW [GOC:TermGenie] synonym: "inhibition of melanosome organization and biogenesis" RELATED [GOC:TermGenie] synonym: "negative regulation of melanosome organisation" EXACT [GOC:TermGenie] synonym: "negative regulation of melanosome organization and biogenesis" RELATED [GOC:TermGenie] is_a: GO:0010639 ! negative regulation of organelle organization is_a: GO:1903056 ! regulation of melanosome organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0032438 ! negatively regulates melanosome organization relationship: RO:0002212 GO:0032438 ! negatively regulates melanosome organization creation_date: 2014-05-27T13:27:55Z [Term] id: GO:1903058 name: positive regulation of melanosome organization namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of melanosome organization." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:24769727] comment: Lack of the transcription factor Zeb2 Q9R0G7 leads to spherical melanosomes with irregular borders, in contrast to the rod-shaped melanosomes of ZEB2MCWT hair follicles. synonym: "activation of melanosome organisation" NARROW [GOC:TermGenie] synonym: "activation of melanosome organization" NARROW [GOC:TermGenie] synonym: "activation of melanosome organization and biogenesis" RELATED [GOC:TermGenie] synonym: "positive regulation of melanosome organisation" EXACT [GOC:TermGenie] synonym: "positive regulation of melanosome organization and biogenesis" RELATED [GOC:TermGenie] synonym: "up regulation of melanosome organisation" EXACT [GOC:TermGenie] synonym: "up regulation of melanosome organization" EXACT [GOC:TermGenie] synonym: "up regulation of melanosome organization and biogenesis" RELATED [GOC:TermGenie] synonym: "up-regulation of melanosome organisation" EXACT [GOC:TermGenie] synonym: "up-regulation of melanosome organization" EXACT [GOC:TermGenie] synonym: "up-regulation of melanosome organization and biogenesis" RELATED [GOC:TermGenie] synonym: "upregulation of melanosome organisation" EXACT [GOC:TermGenie] synonym: "upregulation of melanosome organization" EXACT [GOC:TermGenie] synonym: "upregulation of melanosome organization and biogenesis" RELATED [GOC:TermGenie] is_a: GO:0010638 ! positive regulation of organelle organization is_a: GO:1903056 ! regulation of melanosome organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0032438 ! positively regulates melanosome organization relationship: RO:0002213 GO:0032438 ! positively regulates melanosome organization creation_date: 2014-05-27T13:28:01Z [Term] id: GO:1903076 name: regulation of protein localization to plasma membrane namespace: biological_process def: "Any process that modulates the frequency, rate or extent of protein localization to plasma membrane." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:11602640] synonym: "regulation of establishment of protein localisation in plasma membrane" RELATED [GOC:mah] synonym: "regulation of establishment of protein localization in plasma membrane" RELATED [] synonym: "regulation of establishment of protein localization to plasma membrane" RELATED [] synonym: "regulation of protein localisation in plasma membrane" RELATED [GOC:TermGenie] synonym: "regulation of protein localization in plasma membrane" EXACT [GOC:TermGenie] synonym: "regulation of protein targeting to plasma membrane" RELATED [] synonym: "regulation of protein-plasma membrane targeting" RELATED [GOC:TermGenie] is_a: GO:1904375 ! regulation of protein localization to cell periphery is_a: GO:1905475 ! regulation of protein localization to membrane intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0072659 ! regulates protein localization to plasma membrane relationship: RO:0002211 GO:0072659 ! regulates protein localization to plasma membrane creation_date: 2009-07-10T10:32:44Z [Term] id: GO:1903077 name: negative regulation of protein localization to plasma membrane namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to plasma membrane." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:11602640] synonym: "down regulation of protein localisation in plasma membrane" EXACT [GOC:TermGenie] synonym: "down regulation of protein localization in plasma membrane" EXACT [GOC:TermGenie] synonym: "down regulation of protein localization to plasma membrane" EXACT [GOC:TermGenie] synonym: "down regulation of protein targeting to plasma membrane" RELATED [GOC:TermGenie] synonym: "down regulation of protein-plasma membrane targeting" RELATED [GOC:TermGenie] synonym: "down-regulation of protein localisation in plasma membrane" EXACT [GOC:TermGenie] synonym: "down-regulation of protein localization in plasma membrane" EXACT [GOC:TermGenie] synonym: "down-regulation of protein localization to plasma membrane" EXACT [GOC:TermGenie] synonym: "down-regulation of protein targeting to plasma membrane" RELATED [GOC:TermGenie] synonym: "down-regulation of protein-plasma membrane targeting" RELATED [GOC:TermGenie] synonym: "downregulation of protein localisation in plasma membrane" EXACT [GOC:TermGenie] synonym: "downregulation of protein localization in plasma membrane" EXACT [GOC:TermGenie] synonym: "downregulation of protein localization to plasma membrane" EXACT [GOC:TermGenie] synonym: "downregulation of protein targeting to plasma membrane" RELATED [GOC:TermGenie] synonym: "downregulation of protein-plasma membrane targeting" RELATED [GOC:TermGenie] synonym: "inhibition of protein localisation in plasma membrane" NARROW [GOC:TermGenie] synonym: "inhibition of protein localization in plasma membrane" NARROW [GOC:TermGenie] synonym: "inhibition of protein localization to plasma membrane" NARROW [GOC:TermGenie] synonym: "inhibition of protein targeting to plasma membrane" NARROW [GOC:TermGenie] synonym: "inhibition of protein-plasma membrane targeting" NARROW [GOC:TermGenie] synonym: "negative regulation of establishment of protein localisation in plasma membrane" RELATED [GOC:mah] synonym: "negative regulation of establishment of protein localization in plasma membrane" RELATED [] synonym: "negative regulation of establishment of protein localization to plasma membrane" RELATED [] synonym: "negative regulation of protein localisation in plasma membrane" RELATED [GOC:TermGenie] synonym: "negative regulation of protein localization in plasma membrane" EXACT [GOC:TermGenie] synonym: "negative regulation of protein targeting to plasma membrane" RELATED [] synonym: "negative regulation of protein-plasma membrane targeting" RELATED [GOC:TermGenie] is_a: GO:1903076 ! regulation of protein localization to plasma membrane is_a: GO:1904376 ! negative regulation of protein localization to cell periphery is_a: GO:1905476 ! negative regulation of protein localization to membrane intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0072659 ! negatively regulates protein localization to plasma membrane relationship: RO:0002212 GO:0072659 ! negatively regulates protein localization to plasma membrane creation_date: 2014-05-29T17:10:16Z [Term] id: GO:1903078 name: positive regulation of protein localization to plasma membrane namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of protein localization to plasma membrane." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:11602640] synonym: "activation of protein localisation in plasma membrane" NARROW [GOC:TermGenie] synonym: "activation of protein localization in plasma membrane" NARROW [GOC:TermGenie] synonym: "activation of protein localization to plasma membrane" NARROW [GOC:TermGenie] synonym: "activation of protein targeting to plasma membrane" NARROW [GOC:TermGenie] synonym: "activation of protein-plasma membrane targeting" NARROW [GOC:TermGenie] synonym: "positive regulation of establishment of protein localisation in plasma membrane" RELATED [GOC:mah] synonym: "positive regulation of establishment of protein localization to plasma membrane" RELATED [] synonym: "positive regulation of protein localisation in plasma membrane" EXACT [GOC:TermGenie] synonym: "positive regulation of protein localization in plasma membrane" EXACT [GOC:TermGenie] synonym: "positive regulation of protein targeting to plasma membrane" RELATED [] synonym: "positive regulation of protein-plasma membrane targeting" RELATED [GOC:TermGenie] synonym: "up regulation of protein localisation in plasma membrane" EXACT [GOC:TermGenie] synonym: "up regulation of protein localization in plasma membrane" EXACT [GOC:TermGenie] synonym: "up regulation of protein localization to plasma membrane" EXACT [GOC:TermGenie] synonym: "up regulation of protein targeting to plasma membrane" RELATED [GOC:TermGenie] synonym: "up regulation of protein-plasma membrane targeting" RELATED [GOC:TermGenie] synonym: "up-regulation of protein localisation in plasma membrane" EXACT [GOC:TermGenie] synonym: "up-regulation of protein localization in plasma membrane" EXACT [GOC:TermGenie] synonym: "up-regulation of protein localization to plasma membrane" EXACT [GOC:TermGenie] synonym: "up-regulation of protein targeting to plasma membrane" RELATED [GOC:TermGenie] synonym: "up-regulation of protein-plasma membrane targeting" RELATED [GOC:TermGenie] synonym: "upregulation of protein localisation in plasma membrane" EXACT [GOC:TermGenie] synonym: "upregulation of protein localization in plasma membrane" EXACT [GOC:TermGenie] synonym: "upregulation of protein localization to plasma membrane" EXACT [GOC:TermGenie] synonym: "upregulation of protein targeting to plasma membrane" RELATED [GOC:TermGenie] synonym: "upregulation of protein-plasma membrane targeting" RELATED [GOC:TermGenie] is_a: GO:1903076 ! regulation of protein localization to plasma membrane is_a: GO:1904377 ! positive regulation of protein localization to cell periphery is_a: GO:1905477 ! positive regulation of protein localization to membrane intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0072659 ! positively regulates protein localization to plasma membrane relationship: RO:0002213 GO:0072659 ! positively regulates protein localization to plasma membrane creation_date: 2009-07-10T10:34:17Z [Term] id: GO:1903115 name: regulation of actin filament-based movement namespace: biological_process def: "Any process that modulates the frequency, rate or extent of actin filament-based movement." [GO_REF:0000058, GOC:TermGenie, PMID:24798735] is_a: GO:0032970 ! regulation of actin filament-based process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0030048 ! regulates actin filament-based movement relationship: RO:0002211 GO:0030048 ! regulates actin filament-based movement creation_date: 2014-06-12T16:55:57Z [Term] id: GO:1903116 name: positive regulation of actin filament-based movement namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of actin filament-based movement." [GO_REF:0000058, GOC:TermGenie, PMID:24798735] synonym: "activation of actin filament-based movement" NARROW [GOC:TermGenie] synonym: "up regulation of actin filament-based movement" EXACT [GOC:TermGenie] synonym: "up-regulation of actin filament-based movement" EXACT [GOC:TermGenie] synonym: "upregulation of actin filament-based movement" EXACT [GOC:TermGenie] is_a: GO:0048522 ! positive regulation of cellular process is_a: GO:1903115 ! regulation of actin filament-based movement intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0030048 ! positively regulates actin filament-based movement relationship: RO:0002213 GO:0030048 ! positively regulates actin filament-based movement creation_date: 2014-06-12T16:56:04Z [Term] id: GO:1903119 name: protein localization to actin cytoskeleton namespace: biological_process def: "A process in which a protein is transported to, or maintained in, the location of an actin cytoskeleton." [GO_REF:0000087, GOC:TermGenie, PMID:24798735] synonym: "protein localisation in actin cytoskeleton" EXACT [GOC:TermGenie] synonym: "protein localisation to actin cytoskeleton" EXACT [GOC:TermGenie] synonym: "protein localization in actin cytoskeleton" EXACT [GOC:TermGenie] is_a: GO:0044380 ! protein localization to cytoskeleton intersection_of: GO:0008104 ! intracellular protein localization intersection_of: RO:0002339 GO:0015629 ! has target end location actin cytoskeleton relationship: RO:0002339 GO:0015629 ! has target end location actin cytoskeleton creation_date: 2014-06-16T11:27:09Z [Term] id: GO:1903120 name: protein localization to actin filament bundle namespace: biological_process def: "A process in which a protein is transported to, or maintained in, the location of an actin filament bundle." [GO_REF:0000087, GOC:TermGenie, PMID:24798735] synonym: "protein localisation in actin filament bundle" EXACT [GOC:TermGenie] synonym: "protein localisation to actin filament bundle" EXACT [GOC:TermGenie] synonym: "protein localization in actin filament bundle" EXACT [GOC:TermGenie] synonym: "protein localization to actin cable" RELATED [GOC:mah] is_a: GO:1903119 ! protein localization to actin cytoskeleton intersection_of: GO:0008104 ! intracellular protein localization intersection_of: RO:0002339 GO:0032432 ! has target end location actin filament bundle relationship: RO:0002339 GO:0032432 ! has target end location actin filament bundle creation_date: 2014-06-16T11:27:16Z [Term] id: GO:1903131 name: mononuclear cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires the specialized features of a mononuclear cell." [CL:0000842, GO_REF:0000086, GOC:TermGenie, PMID:24759906] is_a: GO:0002521 ! leukocyte differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000842 ! results in acquisition of features of mononuclear leukocyte relationship: RO:0002315 CL:0000842 ! results in acquisition of features of mononuclear leukocyte creation_date: 2014-06-25T15:47:09Z [Term] id: GO:1903169 name: regulation of calcium ion transmembrane transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of calcium ion transmembrane transport." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:24125847] comment: human HRC regulates RYR2 and thus regulates transmembrane transport of calcium from SR to cytosol synonym: "regulation of calcium ion membrane transport" EXACT [GOC:TermGenie] synonym: "regulation of transmembrane calcium transport" EXACT [GOC:TermGenie] is_a: GO:0051924 ! regulation of calcium ion transport is_a: GO:1904062 ! regulation of monoatomic cation transmembrane transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0070588 ! regulates calcium ion transmembrane transport relationship: RO:0002211 GO:0070588 ! regulates calcium ion transmembrane transport creation_date: 2014-07-11T17:09:26Z [Term] id: GO:1903170 name: negative regulation of calcium ion transmembrane transport namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of calcium ion transmembrane transport." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:24125847] comment: human HRC regulates RYR2 and thus regulates transmembrane transport of calcium from SR to cytosol synonym: "down regulation of calcium ion membrane transport" EXACT [GOC:TermGenie] synonym: "down regulation of calcium ion transmembrane transport" EXACT [GOC:TermGenie] synonym: "down regulation of transmembrane calcium transport" EXACT [GOC:TermGenie] synonym: "down-regulation of calcium ion membrane transport" EXACT [GOC:TermGenie] synonym: "down-regulation of calcium ion transmembrane transport" EXACT [GOC:TermGenie] synonym: "down-regulation of transmembrane calcium transport" EXACT [GOC:TermGenie] synonym: "downregulation of calcium ion membrane transport" EXACT [GOC:TermGenie] synonym: "downregulation of calcium ion transmembrane transport" EXACT [GOC:TermGenie] synonym: "downregulation of transmembrane calcium transport" EXACT [GOC:TermGenie] synonym: "inhibition of calcium ion membrane transport" NARROW [GOC:TermGenie] synonym: "inhibition of calcium ion transmembrane transport" NARROW [GOC:TermGenie] synonym: "inhibition of transmembrane calcium transport" NARROW [GOC:TermGenie] synonym: "negative regulation of calcium ion membrane transport" EXACT [GOC:TermGenie] synonym: "negative regulation of transmembrane calcium transport" EXACT [GOC:TermGenie] is_a: GO:0051926 ! negative regulation of calcium ion transport is_a: GO:1903169 ! regulation of calcium ion transmembrane transport is_a: GO:1904063 ! negative regulation of cation transmembrane transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0070588 ! negatively regulates calcium ion transmembrane transport relationship: RO:0002212 GO:0070588 ! negatively regulates calcium ion transmembrane transport creation_date: 2014-07-11T17:09:32Z [Term] id: GO:1903179 name: regulation of dopamine biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of dopamine biosynthetic process." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie] synonym: "regulation of dopamine anabolism" EXACT [GOC:TermGenie] synonym: "regulation of dopamine biosynthesis" EXACT [GOC:TermGenie] synonym: "regulation of dopamine formation" EXACT [GOC:TermGenie] synonym: "regulation of dopamine synthesis" EXACT [GOC:TermGenie] is_a: GO:0009889 ! regulation of biosynthetic process is_a: GO:0042053 ! regulation of dopamine metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0042416 ! regulates dopamine biosynthetic process relationship: RO:0002211 GO:0042416 ! regulates dopamine biosynthetic process property_value: RO:0002161 NCBITaxon:4751 creation_date: 2014-07-14T12:17:41Z [Term] id: GO:1903180 name: negative regulation of dopamine biosynthetic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of dopamine biosynthetic process." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie] synonym: "down regulation of dopamine anabolism" EXACT [GOC:TermGenie] synonym: "down regulation of dopamine biosynthesis" EXACT [GOC:TermGenie] synonym: "down regulation of dopamine biosynthetic process" EXACT [GOC:TermGenie] synonym: "down regulation of dopamine formation" EXACT [GOC:TermGenie] synonym: "down regulation of dopamine synthesis" EXACT [GOC:TermGenie] synonym: "down-regulation of dopamine anabolism" EXACT [GOC:TermGenie] synonym: "down-regulation of dopamine biosynthesis" EXACT [GOC:TermGenie] synonym: "down-regulation of dopamine biosynthetic process" EXACT [GOC:TermGenie] synonym: "down-regulation of dopamine formation" EXACT [GOC:TermGenie] synonym: "down-regulation of dopamine synthesis" EXACT [GOC:TermGenie] synonym: "downregulation of dopamine anabolism" EXACT [GOC:TermGenie] synonym: "downregulation of dopamine biosynthesis" EXACT [GOC:TermGenie] synonym: "downregulation of dopamine biosynthetic process" EXACT [GOC:TermGenie] synonym: "downregulation of dopamine formation" EXACT [GOC:TermGenie] synonym: "downregulation of dopamine synthesis" EXACT [GOC:TermGenie] synonym: "inhibition of dopamine anabolism" NARROW [GOC:TermGenie] synonym: "inhibition of dopamine biosynthesis" NARROW [GOC:TermGenie] synonym: "inhibition of dopamine biosynthetic process" NARROW [GOC:TermGenie] synonym: "inhibition of dopamine formation" NARROW [GOC:TermGenie] synonym: "inhibition of dopamine synthesis" NARROW [GOC:TermGenie] synonym: "negative regulation of dopamine anabolism" EXACT [GOC:TermGenie] synonym: "negative regulation of dopamine biosynthesis" EXACT [GOC:TermGenie] synonym: "negative regulation of dopamine formation" EXACT [GOC:TermGenie] synonym: "negative regulation of dopamine synthesis" EXACT [GOC:TermGenie] is_a: GO:0009890 ! negative regulation of biosynthetic process is_a: GO:0045963 ! negative regulation of dopamine metabolic process is_a: GO:1903179 ! regulation of dopamine biosynthetic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0042416 ! negatively regulates dopamine biosynthetic process relationship: RO:0002212 GO:0042416 ! negatively regulates dopamine biosynthetic process property_value: RO:0002161 NCBITaxon:4751 creation_date: 2014-07-14T12:17:47Z [Term] id: GO:1903181 name: positive regulation of dopamine biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of dopamine biosynthetic process." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:19703902] synonym: "activation of dopamine anabolism" NARROW [GOC:TermGenie] synonym: "activation of dopamine biosynthesis" NARROW [GOC:TermGenie] synonym: "activation of dopamine biosynthetic process" NARROW [GOC:TermGenie] synonym: "activation of dopamine formation" NARROW [GOC:TermGenie] synonym: "activation of dopamine synthesis" NARROW [GOC:TermGenie] synonym: "positive regulation of dopamine anabolism" EXACT [GOC:TermGenie] synonym: "positive regulation of dopamine biosynthesis" EXACT [GOC:TermGenie] synonym: "positive regulation of dopamine formation" EXACT [GOC:TermGenie] synonym: "positive regulation of dopamine synthesis" EXACT [GOC:TermGenie] synonym: "up regulation of dopamine anabolism" EXACT [GOC:TermGenie] synonym: "up regulation of dopamine biosynthesis" EXACT [GOC:TermGenie] synonym: "up regulation of dopamine biosynthetic process" EXACT [GOC:TermGenie] synonym: "up regulation of dopamine formation" EXACT [GOC:TermGenie] synonym: "up regulation of dopamine synthesis" EXACT [GOC:TermGenie] synonym: "up-regulation of dopamine anabolism" EXACT [GOC:TermGenie] synonym: "up-regulation of dopamine biosynthesis" EXACT [GOC:TermGenie] synonym: "up-regulation of dopamine biosynthetic process" EXACT [GOC:TermGenie] synonym: "up-regulation of dopamine formation" EXACT [GOC:TermGenie] synonym: "up-regulation of dopamine synthesis" EXACT [GOC:TermGenie] synonym: "upregulation of dopamine anabolism" EXACT [GOC:TermGenie] synonym: "upregulation of dopamine biosynthesis" EXACT [GOC:TermGenie] synonym: "upregulation of dopamine biosynthetic process" EXACT [GOC:TermGenie] synonym: "upregulation of dopamine formation" EXACT [GOC:TermGenie] synonym: "upregulation of dopamine synthesis" EXACT [GOC:TermGenie] is_a: GO:0009891 ! positive regulation of biosynthetic process is_a: GO:0045964 ! positive regulation of dopamine metabolic process is_a: GO:1903179 ! regulation of dopamine biosynthetic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0042416 ! positively regulates dopamine biosynthetic process relationship: RO:0002213 GO:0042416 ! positively regulates dopamine biosynthetic process property_value: RO:0002161 NCBITaxon:4751 creation_date: 2014-07-14T12:17:53Z [Term] id: GO:1903210 name: podocyte apoptotic process namespace: biological_process def: "Any apoptotic process in a glomerular visceral epithelial cell." [GO_REF:0000085, GOC:TermGenie, PMID:23515840] synonym: "glomerular podocyte apoptosis" NARROW [GOC:TermGenie] synonym: "glomerular podocyte apoptotic process" EXACT [GOC:TermGenie] synonym: "glomerular visceral epithelial cell apoptosis" NARROW [GOC:TermGenie] synonym: "glomerular visceral epithelial cell apoptotic process" EXACT [] synonym: "podocyte apoptosis" NARROW [GOC:TermGenie] is_a: GO:1904019 ! epithelial cell apoptotic process intersection_of: GO:0006915 ! apoptotic process intersection_of: BFO:0000066 CL:0000653 ! occurs in podocyte relationship: BFO:0000066 CL:0000653 ! occurs in podocyte property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/23000" xsd:anyURI property_value: RO:0002161 NCBITaxon:4751 creation_date: 2014-07-23T17:07:55Z [Term] id: GO:1903224 name: regulation of endodermal cell differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of endodermal cell differentiation." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:23154389] synonym: "regulation of endoderm cell differentiation" EXACT [GOC:TermGenie] is_a: GO:0045595 ! regulation of cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0035987 ! regulates endodermal cell differentiation relationship: RO:0002211 GO:0035987 ! regulates endodermal cell differentiation creation_date: 2014-07-29T13:22:35Z [Term] id: GO:1903225 name: negative regulation of endodermal cell differentiation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of endodermal cell differentiation." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:23154389] synonym: "down regulation of endoderm cell differentiation" EXACT [GOC:TermGenie] synonym: "down regulation of endodermal cell differentiation" EXACT [GOC:TermGenie] synonym: "down-regulation of endoderm cell differentiation" EXACT [GOC:TermGenie] synonym: "down-regulation of endodermal cell differentiation" EXACT [GOC:TermGenie] synonym: "downregulation of endoderm cell differentiation" EXACT [GOC:TermGenie] synonym: "downregulation of endodermal cell differentiation" EXACT [GOC:TermGenie] synonym: "inhibition of endoderm cell differentiation" NARROW [GOC:TermGenie] synonym: "inhibition of endodermal cell differentiation" NARROW [GOC:TermGenie] synonym: "negative regulation of endoderm cell differentiation" EXACT [GOC:TermGenie] is_a: GO:0045596 ! negative regulation of cell differentiation is_a: GO:1903224 ! regulation of endodermal cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0035987 ! negatively regulates endodermal cell differentiation relationship: RO:0002212 GO:0035987 ! negatively regulates endodermal cell differentiation creation_date: 2014-07-29T13:22:41Z [Term] id: GO:1903226 name: positive regulation of endodermal cell differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of endodermal cell differentiation." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:23154389] synonym: "activation of endoderm cell differentiation" NARROW [GOC:TermGenie] synonym: "activation of endodermal cell differentiation" NARROW [GOC:TermGenie] synonym: "positive regulation of endoderm cell differentiation" EXACT [GOC:TermGenie] synonym: "up regulation of endoderm cell differentiation" EXACT [GOC:TermGenie] synonym: "up regulation of endodermal cell differentiation" EXACT [GOC:TermGenie] synonym: "up-regulation of endoderm cell differentiation" EXACT [GOC:TermGenie] synonym: "up-regulation of endodermal cell differentiation" EXACT [GOC:TermGenie] synonym: "upregulation of endoderm cell differentiation" EXACT [GOC:TermGenie] synonym: "upregulation of endodermal cell differentiation" EXACT [GOC:TermGenie] is_a: GO:0045597 ! positive regulation of cell differentiation is_a: GO:1903224 ! regulation of endodermal cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0035987 ! positively regulates endodermal cell differentiation relationship: RO:0002213 GO:0035987 ! positively regulates endodermal cell differentiation creation_date: 2014-07-29T13:22:47Z [Term] id: GO:1903232 name: melanosome assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form a melanosome, a tissue-specific, membrane-bounded cytoplasmic organelle within which melanin pigments are synthesized and stored." [GO_REF:0000079, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:22511774] synonym: "melanosome formation" EXACT [GOC:TermGenie] is_a: GO:0032438 ! melanosome organization is_a: GO:0070925 ! organelle assembly intersection_of: GO:0022607 ! cellular component assembly intersection_of: RO:0002588 GO:0042470 ! results in assembly of melanosome relationship: RO:0002588 GO:0042470 ! results in assembly of melanosome creation_date: 2014-07-31T10:41:38Z [Term] id: GO:1903233 name: regulation of calcium ion-dependent exocytosis of neurotransmitter namespace: biological_process def: "Any process that modulates the frequency, rate or extent of calcium ion-dependent exocytosis of neurotransmitter." [GO_REF:0000058, GOC:TermGenie, PMID:16782817] comment: An example of this is Rab3gap1 in mouse (Q80UJ7) in PMID:16782817 (IMP) is_a: GO:0017158 ! regulation of calcium ion-dependent exocytosis is_a: GO:2000300 ! regulation of synaptic vesicle exocytosis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0048791 ! regulates calcium ion-regulated exocytosis of neurotransmitter relationship: RO:0002211 GO:0048791 ! regulates calcium ion-regulated exocytosis of neurotransmitter creation_date: 2014-07-31T11:54:33Z [Term] id: GO:1903234 name: negative regulation of calcium ion-dependent exocytosis of neurotransmitter namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of calcium ion-dependent exocytosis of neurotransmitter." [GO_REF:0000058, GOC:TermGenie, PMID:16782817] comment: An example of this is Rab3gap1 in mouse (Q80UJ7) in PMID:16782817 (IMP) synonym: "down regulation of calcium ion-dependent exocytosis of neurotransmitter" EXACT [GOC:TermGenie] synonym: "down-regulation of calcium ion-dependent exocytosis of neurotransmitter" EXACT [GOC:TermGenie] synonym: "downregulation of calcium ion-dependent exocytosis of neurotransmitter" EXACT [GOC:TermGenie] synonym: "inhibition of calcium ion-dependent exocytosis of neurotransmitter" NARROW [GOC:TermGenie] is_a: GO:0045955 ! negative regulation of calcium ion-dependent exocytosis is_a: GO:1903233 ! regulation of calcium ion-dependent exocytosis of neurotransmitter is_a: GO:2000301 ! negative regulation of synaptic vesicle exocytosis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0048791 ! negatively regulates calcium ion-regulated exocytosis of neurotransmitter relationship: RO:0002212 GO:0048791 ! negatively regulates calcium ion-regulated exocytosis of neurotransmitter creation_date: 2014-07-31T11:54:40Z [Term] id: GO:1903235 name: positive regulation of calcium ion-dependent exocytosis of neurotransmitter namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of calcium ion-dependent exocytosis of neurotransmitter." [GO_REF:0000058, GOC:TermGenie, PMID:16782817] comment: An example of this is Rab3gap1 in mouse (Q80UJ7) in PMID:16782817 (IMP) synonym: "activation of calcium ion-dependent exocytosis of neurotransmitter" NARROW [GOC:TermGenie] synonym: "up regulation of calcium ion-dependent exocytosis of neurotransmitter" EXACT [GOC:TermGenie] synonym: "up-regulation of calcium ion-dependent exocytosis of neurotransmitter" EXACT [GOC:TermGenie] synonym: "upregulation of calcium ion-dependent exocytosis of neurotransmitter" EXACT [GOC:TermGenie] is_a: GO:0045956 ! positive regulation of calcium ion-dependent exocytosis is_a: GO:1903233 ! regulation of calcium ion-dependent exocytosis of neurotransmitter is_a: GO:2000302 ! positive regulation of synaptic vesicle exocytosis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0048791 ! positively regulates calcium ion-regulated exocytosis of neurotransmitter relationship: RO:0002213 GO:0048791 ! positively regulates calcium ion-regulated exocytosis of neurotransmitter creation_date: 2014-07-31T11:54:46Z [Term] id: GO:1903251 name: multi-ciliated epithelial cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires the specialized features of a multi-ciliated epithelial cell." [GO_REF:0000086, GOC:sp, GOC:TermGenie, PMID:22231168, PMID:24934224] synonym: "multiciliate cell differentiation" BROAD [] is_a: GO:0002065 ! columnar/cuboidal epithelial cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0005012 ! results in acquisition of features of multiciliated epithelial cell relationship: RO:0002315 CL:0005012 ! results in acquisition of features of multiciliated epithelial cell creation_date: 2014-08-05T19:21:21Z [Term] id: GO:1903276 name: regulation of sodium ion export across plasma membrane namespace: biological_process def: "Any process that modulates the frequency, rate or extent of sodium ion export across the plasma membrane." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:17095720] synonym: "regulation of sodium export" RELATED [GOC:TermGenie] synonym: "regulation of sodium ion export" RELATED [] synonym: "regulation of sodium ion export from cell" EXACT [] is_a: GO:1902305 ! regulation of sodium ion transmembrane transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0036376 ! regulates sodium ion export across plasma membrane relationship: RO:0002211 GO:0036376 ! regulates sodium ion export across plasma membrane creation_date: 2014-08-08T17:06:46Z [Term] id: GO:1903277 name: negative regulation of sodium ion export across plasma membrane namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of sodium ion export across the plasma membrane." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:17095720] synonym: "down regulation of sodium export" RELATED [GOC:TermGenie] synonym: "down regulation of sodium ion export" RELATED [GOC:TermGenie] synonym: "down regulation of sodium ion export from cell" EXACT [GOC:TermGenie] synonym: "down-regulation of sodium export" RELATED [GOC:TermGenie] synonym: "down-regulation of sodium ion export" RELATED [GOC:TermGenie] synonym: "down-regulation of sodium ion export from cell" EXACT [GOC:TermGenie] synonym: "downregulation of sodium export" RELATED [GOC:TermGenie] synonym: "downregulation of sodium ion export" RELATED [GOC:TermGenie] synonym: "downregulation of sodium ion export from cell" EXACT [GOC:TermGenie] synonym: "inhibition of sodium export" NARROW [GOC:TermGenie] synonym: "inhibition of sodium ion export" NARROW [GOC:TermGenie] synonym: "inhibition of sodium ion export from cell" NARROW [GOC:TermGenie] synonym: "negative regulation of sodium export" RELATED [GOC:TermGenie] synonym: "negative regulation of sodium ion export" RELATED [] synonym: "negative regulation of sodium ion export from cell" EXACT [] is_a: GO:1902306 ! negative regulation of sodium ion transmembrane transport is_a: GO:1903276 ! regulation of sodium ion export across plasma membrane intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0036376 ! negatively regulates sodium ion export across plasma membrane relationship: RO:0002212 GO:0036376 ! negatively regulates sodium ion export across plasma membrane creation_date: 2014-08-08T17:10:22Z [Term] id: GO:1903278 name: positive regulation of sodium ion export across plasma membrane namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of sodium ion export across the plasma membrane." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:17095720] synonym: "activation of sodium export" NARROW [GOC:TermGenie] synonym: "activation of sodium ion export" NARROW [GOC:TermGenie] synonym: "activation of sodium ion export from cell" NARROW [GOC:TermGenie] synonym: "positive regulation of sodium export" RELATED [GOC:TermGenie] synonym: "positive regulation of sodium ion export" RELATED [] synonym: "positive regulation of sodium ion export from cell" EXACT [] synonym: "up regulation of sodium export" RELATED [GOC:TermGenie] synonym: "up regulation of sodium ion export" RELATED [GOC:TermGenie] synonym: "up regulation of sodium ion export from cell" EXACT [GOC:TermGenie] synonym: "up-regulation of sodium export" RELATED [GOC:TermGenie] synonym: "up-regulation of sodium ion export" RELATED [GOC:TermGenie] synonym: "up-regulation of sodium ion export from cell" EXACT [GOC:TermGenie] synonym: "upregulation of sodium export" RELATED [GOC:TermGenie] synonym: "upregulation of sodium ion export" RELATED [GOC:TermGenie] synonym: "upregulation of sodium ion export from cell" EXACT [GOC:TermGenie] is_a: GO:1902307 ! positive regulation of sodium ion transmembrane transport is_a: GO:1903276 ! regulation of sodium ion export across plasma membrane intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0036376 ! positively regulates sodium ion export across plasma membrane relationship: RO:0002213 GO:0036376 ! positively regulates sodium ion export across plasma membrane creation_date: 2014-08-08T17:10:30Z [Term] id: GO:1903286 name: regulation of potassium ion import namespace: biological_process def: "Any process that modulates the frequency, rate or extent of potassium ion import." [GO_REF:0000058, GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:rl, GOC:TermGenie, PMID:10636900] synonym: "regulation of potassium import" EXACT [GOC:TermGenie] synonym: "regulation of potassium ion uptake" EXACT [GOC:TermGenie] is_a: GO:1901379 ! regulation of potassium ion transmembrane transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:1990573 ! regulates potassium ion import across plasma membrane relationship: RO:0002211 GO:1990573 ! regulates potassium ion import across plasma membrane creation_date: 2014-08-11T14:26:16Z [Term] id: GO:1903287 name: negative regulation of potassium ion import across plasma membrane namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of potassium ion import across the plasma membrane." [GO_REF:0000058, GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:rl, GOC:TermGenie, PMID:10636900] synonym: "down regulation of potassium import" BROAD [GOC:TermGenie] synonym: "down regulation of potassium ion import" BROAD [GOC:TermGenie] synonym: "down regulation of potassium ion uptake" BROAD [GOC:TermGenie] synonym: "down-regulation of potassium import" BROAD [GOC:TermGenie] synonym: "down-regulation of potassium ion import" BROAD [GOC:TermGenie] synonym: "down-regulation of potassium ion uptake" BROAD [GOC:TermGenie] synonym: "downregulation of potassium import" BROAD [GOC:TermGenie] synonym: "downregulation of potassium ion import" BROAD [GOC:TermGenie] synonym: "downregulation of potassium ion uptake" BROAD [GOC:TermGenie] synonym: "inhibition of potassium import" NARROW [GOC:TermGenie] synonym: "inhibition of potassium ion import" NARROW [GOC:TermGenie] synonym: "inhibition of potassium ion uptake" NARROW [GOC:TermGenie] synonym: "negative regulation of potassium import" BROAD [GOC:TermGenie] synonym: "negative regulation of potassium ion import" BROAD [] synonym: "negative regulation of potassium ion uptake" BROAD [GOC:TermGenie] is_a: GO:1901380 ! negative regulation of potassium ion transmembrane transport is_a: GO:1903286 ! regulation of potassium ion import intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:1990573 ! negatively regulates potassium ion import across plasma membrane relationship: RO:0002212 GO:1990573 ! negatively regulates potassium ion import across plasma membrane creation_date: 2014-08-11T14:26:24Z [Term] id: GO:1903288 name: positive regulation of potassium ion import across plasma membrane namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of potassium ion import across the plasma membrane." [GO_REF:0000058, GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:rl, GOC:TermGenie, PMID:10636900] synonym: "activation of potassium import" NARROW [GOC:TermGenie] synonym: "activation of potassium ion import" NARROW [GOC:TermGenie] synonym: "activation of potassium ion uptake" NARROW [GOC:TermGenie] synonym: "positive regulation of potassium import" EXACT [GOC:TermGenie] synonym: "positive regulation of potassium ion import" BROAD [] synonym: "positive regulation of potassium ion uptake" EXACT [GOC:TermGenie] synonym: "up regulation of potassium import" EXACT [GOC:TermGenie] synonym: "up regulation of potassium ion import" EXACT [GOC:TermGenie] synonym: "up regulation of potassium ion uptake" EXACT [GOC:TermGenie] synonym: "up-regulation of potassium import" EXACT [GOC:TermGenie] synonym: "up-regulation of potassium ion import" EXACT [GOC:TermGenie] synonym: "up-regulation of potassium ion uptake" EXACT [GOC:TermGenie] synonym: "upregulation of potassium import" EXACT [GOC:TermGenie] synonym: "upregulation of potassium ion import" EXACT [GOC:TermGenie] synonym: "upregulation of potassium ion uptake" EXACT [GOC:TermGenie] is_a: GO:1901381 ! positive regulation of potassium ion transmembrane transport is_a: GO:1903286 ! regulation of potassium ion import intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:1990573 ! positively regulates potassium ion import across plasma membrane relationship: RO:0002213 GO:1990573 ! positively regulates potassium ion import across plasma membrane creation_date: 2014-08-11T14:26:32Z [Term] id: GO:1903292 name: protein localization to Golgi membrane namespace: biological_process def: "A process in which a protein is transported to, or maintained in, a location within a Golgi membrane." [GO_REF:0000087, GOC:TermGenie, PMID:11378902] synonym: "protein localisation in Golgi membrane" EXACT [GOC:TermGenie] synonym: "protein localisation to Golgi membrane" EXACT [GOC:TermGenie] synonym: "protein localization in Golgi membrane" EXACT [GOC:TermGenie] is_a: GO:0034067 ! protein localization to Golgi apparatus is_a: GO:0072657 ! protein localization to membrane intersection_of: GO:0008104 ! intracellular protein localization intersection_of: RO:0002339 GO:0000139 ! has target end location Golgi membrane relationship: RO:0002339 GO:0000139 ! has target end location Golgi membrane creation_date: 2014-08-12T14:22:31Z [Term] id: GO:1903294 name: regulation of glutamate secretion, neurotransmission namespace: biological_process def: "Any process that modulates the frequency, rate or extent of glutamate secretion, neurotransmission." [GO_REF:0000058, GOC:TermGenie, PMID:16782817] comment: An example of this is Rab3gap1 in mouse (Q80UJ7) in PMID:16782817 inferred from mutant phenotype is_a: GO:0014048 ! regulation of glutamate secretion is_a: GO:0046928 ! regulation of neurotransmitter secretion is_a: GO:0051966 ! regulation of synaptic transmission, glutamatergic intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0061535 ! regulates glutamate secretion, neurotransmission relationship: RO:0002211 GO:0061535 ! regulates glutamate secretion, neurotransmission creation_date: 2014-08-13T13:54:15Z [Term] id: GO:1903295 name: negative regulation of glutamate secretion, neurotransmission namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of glutamate secretion, neurotransmission." [GO_REF:0000058, GOC:TermGenie, PMID:16782817] comment: An example of this is Rab3gap1 in mouse (Q80UJ7) in PMID:16782817 inferred from mutant phenotype synonym: "down regulation of glutamate secretion, neurotransmission" EXACT [GOC:TermGenie] synonym: "down-regulation of glutamate secretion, neurotransmission" EXACT [GOC:TermGenie] synonym: "downregulation of glutamate secretion, neurotransmission" EXACT [GOC:TermGenie] synonym: "inhibition of glutamate secretion, neurotransmission" NARROW [GOC:TermGenie] is_a: GO:0014050 ! negative regulation of glutamate secretion is_a: GO:0046929 ! negative regulation of neurotransmitter secretion is_a: GO:0051967 ! negative regulation of synaptic transmission, glutamatergic is_a: GO:1903294 ! regulation of glutamate secretion, neurotransmission intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0061535 ! negatively regulates glutamate secretion, neurotransmission relationship: RO:0002212 GO:0061535 ! negatively regulates glutamate secretion, neurotransmission creation_date: 2014-08-13T13:54:23Z [Term] id: GO:1903296 name: positive regulation of glutamate secretion, neurotransmission namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of glutamate secretion, where glutamate acts as a neurotransmitter." [GO_REF:0000058, GOC:TermGenie, PMID:16782817] comment: An example of this is Rab3gap1 in mouse (Q80UJ7) in PMID:16782817 inferred from mutant phenotype synonym: "activation of glutamate secretion, neurotransmission" NARROW [GOC:TermGenie] synonym: "up regulation of glutamate secretion, neurotransmission" EXACT [GOC:TermGenie] synonym: "up-regulation of glutamate secretion, neurotransmission" EXACT [GOC:TermGenie] synonym: "upregulation of glutamate secretion, neurotransmission" EXACT [GOC:TermGenie] is_a: GO:0001956 ! positive regulation of neurotransmitter secretion is_a: GO:0014049 ! positive regulation of glutamate secretion is_a: GO:0051968 ! positive regulation of synaptic transmission, glutamatergic is_a: GO:1903294 ! regulation of glutamate secretion, neurotransmission intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0061535 ! positively regulates glutamate secretion, neurotransmission relationship: RO:0002213 GO:0061535 ! positively regulates glutamate secretion, neurotransmission creation_date: 2014-08-13T13:54:31Z [Term] id: GO:1903305 name: regulation of regulated secretory pathway namespace: biological_process def: "Any process that modulates the frequency, rate or extent of regulated secretory pathway." [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:12526776] comment: An example of this is protein domain-specific expression of Synaptotagmin 1 in rat (P21707) in PMID:12526776 inferred from mutant phenotype. is_a: GO:0017157 ! regulation of exocytosis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0045055 ! regulates regulated exocytosis relationship: RO:0002211 GO:0045055 ! regulates regulated exocytosis creation_date: 2014-08-18T10:04:53Z [Term] id: GO:1903306 name: negative regulation of regulated secretory pathway namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of regulated secretory pathway." [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:12526776] comment: An example of this is protein domain-specific expression of Synaptotagmin 1 in rat (P21707) in PMID:12526776 inferred from mutant phenotype. synonym: "down regulation of regulated secretory pathway" EXACT [GOC:TermGenie] synonym: "down-regulation of regulated secretory pathway" EXACT [GOC:TermGenie] synonym: "downregulation of regulated secretory pathway" EXACT [GOC:TermGenie] synonym: "inhibition of regulated secretory pathway" NARROW [GOC:TermGenie] is_a: GO:0045920 ! negative regulation of exocytosis is_a: GO:1903305 ! regulation of regulated secretory pathway intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0045055 ! negatively regulates regulated exocytosis relationship: RO:0002212 GO:0045055 ! negatively regulates regulated exocytosis creation_date: 2014-08-18T10:05:02Z [Term] id: GO:1903307 name: positive regulation of regulated secretory pathway namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of regulated secretory pathway." [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:12526776] comment: An example of this is protein domain-specific expression of Synaptotagmin 1 in rat (P21707) in PMID:12526776 inferred from mutant phenotype. synonym: "activation of regulated secretory pathway" NARROW [GOC:TermGenie] synonym: "up regulation of regulated secretory pathway" EXACT [GOC:TermGenie] synonym: "up-regulation of regulated secretory pathway" EXACT [GOC:TermGenie] synonym: "upregulation of regulated secretory pathway" EXACT [GOC:TermGenie] is_a: GO:0045921 ! positive regulation of exocytosis is_a: GO:1903305 ! regulation of regulated secretory pathway intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0045055 ! positively regulates regulated exocytosis relationship: RO:0002213 GO:0045055 ! positively regulates regulated exocytosis creation_date: 2014-08-18T10:05:10Z [Term] id: GO:1903314 name: regulation of nitrogen cycle metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of nitrogen cycle metabolic process." [GO_REF:0000058, GOC:TermGenie, GOC:vw] is_a: GO:0019222 ! regulation of metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0071941 ! regulates nitrogen cycle metabolic process relationship: RO:0002211 GO:0071941 ! regulates nitrogen cycle metabolic process creation_date: 2014-08-18T12:57:34Z [Term] id: GO:1903315 name: negative regulation of nitrogen cycle metabolic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of nitrogen cycle metabolic process." [GO_REF:0000058, GOC:TermGenie, GOC:vw] synonym: "down regulation of nitrogen cycle metabolic process" EXACT [GOC:TermGenie] synonym: "down-regulation of nitrogen cycle metabolic process" EXACT [GOC:TermGenie] synonym: "downregulation of nitrogen cycle metabolic process" EXACT [GOC:TermGenie] synonym: "inhibition of nitrogen cycle metabolic process" NARROW [GOC:TermGenie] is_a: GO:0009892 ! negative regulation of metabolic process is_a: GO:1903314 ! regulation of nitrogen cycle metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0071941 ! negatively regulates nitrogen cycle metabolic process relationship: RO:0002212 GO:0071941 ! negatively regulates nitrogen cycle metabolic process creation_date: 2014-08-18T12:57:42Z [Term] id: GO:1903316 name: positive regulation of nitrogen cycle metabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of nitrogen cycle metabolic process." [GO_REF:0000058, GOC:TermGenie, GOC:vw] synonym: "activation of nitrogen cycle metabolic process" NARROW [GOC:TermGenie] synonym: "up regulation of nitrogen cycle metabolic process" EXACT [GOC:TermGenie] synonym: "up-regulation of nitrogen cycle metabolic process" EXACT [GOC:TermGenie] synonym: "upregulation of nitrogen cycle metabolic process" EXACT [GOC:TermGenie] is_a: GO:0009893 ! positive regulation of metabolic process is_a: GO:1903314 ! regulation of nitrogen cycle metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0071941 ! positively regulates nitrogen cycle metabolic process relationship: RO:0002213 GO:0071941 ! positively regulates nitrogen cycle metabolic process creation_date: 2014-08-18T12:57:50Z [Term] id: GO:1903317 name: regulation of protein maturation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of protein maturation." [GO_REF:0000058, GOC:TermGenie, GOC:vw] is_a: GO:0010468 ! regulation of gene expression is_a: GO:0051246 ! regulation of protein metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0051604 ! regulates protein maturation relationship: RO:0002211 GO:0051604 ! regulates protein maturation creation_date: 2014-08-18T12:59:07Z [Term] id: GO:1903318 name: negative regulation of protein maturation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein maturation." [GO_REF:0000058, GOC:TermGenie, GOC:vw] synonym: "down regulation of protein maturation" EXACT [GOC:TermGenie] synonym: "down-regulation of protein maturation" EXACT [GOC:TermGenie] synonym: "downregulation of protein maturation" EXACT [GOC:TermGenie] synonym: "inhibition of protein maturation" NARROW [GOC:TermGenie] is_a: GO:0010629 ! negative regulation of gene expression is_a: GO:0051248 ! negative regulation of protein metabolic process is_a: GO:1903317 ! regulation of protein maturation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0051604 ! negatively regulates protein maturation relationship: RO:0002212 GO:0051604 ! negatively regulates protein maturation creation_date: 2014-08-18T12:59:15Z [Term] id: GO:1903319 name: positive regulation of protein maturation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of protein maturation." [GO_REF:0000058, GOC:TermGenie, GOC:vw] synonym: "activation of protein maturation" NARROW [GOC:TermGenie] synonym: "up regulation of protein maturation" EXACT [GOC:TermGenie] synonym: "up-regulation of protein maturation" EXACT [GOC:TermGenie] synonym: "upregulation of protein maturation" EXACT [GOC:TermGenie] is_a: GO:0010628 ! positive regulation of gene expression is_a: GO:0051247 ! positive regulation of protein metabolic process is_a: GO:1903317 ! regulation of protein maturation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0051604 ! positively regulates protein maturation relationship: RO:0002213 GO:0051604 ! positively regulates protein maturation creation_date: 2014-08-18T12:59:23Z [Term] id: GO:1903326 name: regulation of tRNA metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of tRNA metabolic process." [GO_REF:0000058, GOC:TermGenie, GOC:vw] synonym: "regulation of tRNA metabolism" EXACT [GOC:TermGenie] is_a: GO:0051252 ! regulation of RNA metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0006399 ! regulates tRNA metabolic process relationship: RO:0002211 GO:0006399 ! regulates tRNA metabolic process creation_date: 2014-08-18T13:08:50Z [Term] id: GO:1903327 name: negative regulation of tRNA metabolic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of tRNA metabolic process." [GO_REF:0000058, GOC:TermGenie, GOC:vw] synonym: "down regulation of tRNA metabolic process" EXACT [GOC:TermGenie] synonym: "down regulation of tRNA metabolism" EXACT [GOC:TermGenie] synonym: "down-regulation of tRNA metabolic process" EXACT [GOC:TermGenie] synonym: "down-regulation of tRNA metabolism" EXACT [GOC:TermGenie] synonym: "downregulation of tRNA metabolic process" EXACT [GOC:TermGenie] synonym: "downregulation of tRNA metabolism" EXACT [GOC:TermGenie] synonym: "inhibition of tRNA metabolic process" NARROW [GOC:TermGenie] synonym: "inhibition of tRNA metabolism" NARROW [GOC:TermGenie] synonym: "negative regulation of tRNA metabolism" EXACT [GOC:TermGenie] is_a: GO:0051253 ! negative regulation of RNA metabolic process is_a: GO:1903326 ! regulation of tRNA metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0006399 ! negatively regulates tRNA metabolic process relationship: RO:0002212 GO:0006399 ! negatively regulates tRNA metabolic process creation_date: 2014-08-18T13:08:58Z [Term] id: GO:1903328 name: positive regulation of tRNA metabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of tRNA metabolic process." [GO_REF:0000058, GOC:TermGenie, GOC:vw] synonym: "activation of tRNA metabolic process" NARROW [GOC:TermGenie] synonym: "activation of tRNA metabolism" NARROW [GOC:TermGenie] synonym: "positive regulation of tRNA metabolism" EXACT [GOC:TermGenie] synonym: "up regulation of tRNA metabolic process" EXACT [GOC:TermGenie] synonym: "up regulation of tRNA metabolism" EXACT [GOC:TermGenie] synonym: "up-regulation of tRNA metabolic process" EXACT [GOC:TermGenie] synonym: "up-regulation of tRNA metabolism" EXACT [GOC:TermGenie] synonym: "upregulation of tRNA metabolic process" EXACT [GOC:TermGenie] synonym: "upregulation of tRNA metabolism" EXACT [GOC:TermGenie] is_a: GO:0051254 ! positive regulation of RNA metabolic process is_a: GO:1903326 ! regulation of tRNA metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0006399 ! positively regulates tRNA metabolic process relationship: RO:0002213 GO:0006399 ! positively regulates tRNA metabolic process creation_date: 2014-08-18T13:09:06Z [Term] id: GO:1903335 name: regulation of vacuolar transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of vacuolar transport." [GO_REF:0000058, GOC:TermGenie, GOC:vw] is_a: GO:0032386 ! regulation of intracellular transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0007034 ! regulates vacuolar transport relationship: RO:0002211 GO:0007034 ! regulates vacuolar transport creation_date: 2014-08-18T13:16:04Z [Term] id: GO:1903336 name: negative regulation of vacuolar transport namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of vacuolar transport." [GO_REF:0000058, GOC:TermGenie, GOC:vw] synonym: "down regulation of vacuolar transport" EXACT [GOC:TermGenie] synonym: "down-regulation of vacuolar transport" EXACT [GOC:TermGenie] synonym: "downregulation of vacuolar transport" EXACT [GOC:TermGenie] synonym: "inhibition of vacuolar transport" NARROW [GOC:TermGenie] is_a: GO:0032387 ! negative regulation of intracellular transport is_a: GO:1903335 ! regulation of vacuolar transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0007034 ! negatively regulates vacuolar transport relationship: RO:0002212 GO:0007034 ! negatively regulates vacuolar transport creation_date: 2014-08-18T13:16:11Z [Term] id: GO:1903337 name: positive regulation of vacuolar transport namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of vacuolar transport." [GO_REF:0000058, GOC:TermGenie, GOC:vw] synonym: "activation of vacuolar transport" NARROW [GOC:TermGenie] synonym: "up regulation of vacuolar transport" EXACT [GOC:TermGenie] synonym: "up-regulation of vacuolar transport" EXACT [GOC:TermGenie] synonym: "upregulation of vacuolar transport" EXACT [GOC:TermGenie] is_a: GO:0032388 ! positive regulation of intracellular transport is_a: GO:1903335 ! regulation of vacuolar transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0007034 ! positively regulates vacuolar transport relationship: RO:0002213 GO:0007034 ! positively regulates vacuolar transport creation_date: 2014-08-18T13:16:19Z [Term] id: GO:1903347 name: negative regulation of bicellular tight junction assembly namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of tight junction assembly." [GO_REF:0000058, GOC:jz, GOC:TermGenie, PMID:25050009] synonym: "down regulation of tight junction assembly" EXACT [GOC:TermGenie] synonym: "down regulation of tight junction formation" EXACT [GOC:TermGenie] synonym: "down-regulation of tight junction assembly" EXACT [GOC:TermGenie] synonym: "down-regulation of tight junction formation" EXACT [GOC:TermGenie] synonym: "downregulation of tight junction assembly" EXACT [GOC:TermGenie] synonym: "downregulation of tight junction formation" EXACT [GOC:TermGenie] synonym: "inhibition of tight junction assembly" NARROW [GOC:TermGenie] synonym: "inhibition of tight junction formation" NARROW [GOC:TermGenie] synonym: "negative regulation of tight junction formation" EXACT [GOC:TermGenie] is_a: GO:1901889 ! negative regulation of cell junction assembly is_a: GO:2000810 ! regulation of bicellular tight junction assembly intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0070830 ! negatively regulates bicellular tight junction assembly relationship: RO:0002212 GO:0070830 ! negatively regulates bicellular tight junction assembly property_value: RO:0002161 NCBITaxon:4751 creation_date: 2014-08-19T11:02:14Z [Term] id: GO:1903348 name: positive regulation of bicellular tight junction assembly namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of tight junction assembly." [GO_REF:0000058, GOC:jz, GOC:TermGenie, PMID:25050009] synonym: "activation of tight junction assembly" NARROW [GOC:TermGenie] synonym: "activation of tight junction formation" NARROW [GOC:TermGenie] synonym: "positive regulation of tight junction formation" EXACT [GOC:TermGenie] synonym: "up regulation of tight junction assembly" EXACT [GOC:TermGenie] synonym: "up regulation of tight junction formation" EXACT [GOC:TermGenie] synonym: "up-regulation of tight junction assembly" EXACT [GOC:TermGenie] synonym: "up-regulation of tight junction formation" EXACT [GOC:TermGenie] synonym: "upregulation of tight junction assembly" EXACT [GOC:TermGenie] synonym: "upregulation of tight junction formation" EXACT [GOC:TermGenie] is_a: GO:1901890 ! positive regulation of cell junction assembly is_a: GO:2000810 ! regulation of bicellular tight junction assembly intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0070830 ! positively regulates bicellular tight junction assembly relationship: RO:0002213 GO:0070830 ! positively regulates bicellular tight junction assembly property_value: RO:0002161 NCBITaxon:4751 creation_date: 2014-08-19T11:05:06Z [Term] id: GO:1903350 name: response to dopamine namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a dopamine stimulus." [GO_REF:0000071, GOC:mr, GOC:TermGenie, PMID:11118945] is_a: GO:0071869 ! response to catecholamine intersection_of: GO:0050896 ! response to stimulus intersection_of: RO:0004009 CHEBI:59905 ! has primary input relationship: RO:0004009 CHEBI:59905 ! has primary input creation_date: 2014-08-19T19:33:26Z [Term] id: GO:1903351 name: cellular response to dopamine namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a dopamine stimulus." [GO_REF:0000071, GOC:mr, GOC:TermGenie, PMID:11118945] is_a: GO:0071870 ! cellular response to catecholamine stimulus is_a: GO:1903350 ! response to dopamine intersection_of: GO:0070887 ! cellular response to chemical stimulus intersection_of: RO:0004009 CHEBI:59905 ! has primary input creation_date: 2014-08-19T19:33:35Z [Term] id: GO:1903353 name: regulation of nucleus organization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of nucleus organization." [GO_REF:0000058, GOC:TermGenie, PMID:16943282] synonym: "regulation of nuclear morphology" RELATED [GOC:TermGenie] synonym: "regulation of nuclear organisation" EXACT [GOC:TermGenie] synonym: "regulation of nuclear organization" EXACT [GOC:TermGenie] synonym: "regulation of nuclear organization and biogenesis" RELATED [GOC:TermGenie] synonym: "regulation of nucleus organization and biogenesis" RELATED [GOC:TermGenie] is_a: GO:0033043 ! regulation of organelle organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0006997 ! regulates nucleus organization relationship: RO:0002211 GO:0006997 ! regulates nucleus organization creation_date: 2014-08-20T19:36:16Z [Term] id: GO:1903354 name: regulation of distal tip cell migration namespace: biological_process def: "Any process that modulates the frequency, rate or extent of distal tip cell migration." [GO_REF:0000058, GOC:mm2, GOC:TermGenie, PMID:24968003] is_a: GO:0030334 ! regulation of cell migration intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0097628 ! regulates distal tip cell migration relationship: RO:0002211 GO:0097628 ! regulates distal tip cell migration property_value: RO:0002161 NCBITaxon:451864 creation_date: 2014-08-21T10:05:08Z [Term] id: GO:1903355 name: negative regulation of distal tip cell migration namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of distal tip cell migration." [GO_REF:0000058, GOC:mm2, GOC:TermGenie, PMID:24968003] synonym: "down regulation of distal tip cell migration" EXACT [GOC:TermGenie] synonym: "down-regulation of distal tip cell migration" EXACT [GOC:TermGenie] synonym: "downregulation of distal tip cell migration" EXACT [GOC:TermGenie] synonym: "inhibition of distal tip cell migration" NARROW [GOC:TermGenie] is_a: GO:0030336 ! negative regulation of cell migration is_a: GO:1903354 ! regulation of distal tip cell migration intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0097628 ! negatively regulates distal tip cell migration relationship: RO:0002212 GO:0097628 ! negatively regulates distal tip cell migration property_value: RO:0002161 NCBITaxon:451864 creation_date: 2014-08-21T10:05:17Z [Term] id: GO:1903356 name: positive regulation of distal tip cell migration namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of distal tip cell migration." [GO_REF:0000058, GOC:mm2, GOC:TermGenie, PMID:24968003] synonym: "activation of distal tip cell migration" NARROW [GOC:TermGenie] synonym: "up regulation of distal tip cell migration" EXACT [GOC:TermGenie] synonym: "up-regulation of distal tip cell migration" EXACT [GOC:TermGenie] synonym: "upregulation of distal tip cell migration" EXACT [GOC:TermGenie] is_a: GO:0030335 ! positive regulation of cell migration is_a: GO:1903354 ! regulation of distal tip cell migration intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0097628 ! positively regulates distal tip cell migration relationship: RO:0002213 GO:0097628 ! positively regulates distal tip cell migration property_value: RO:0002161 NCBITaxon:451864 creation_date: 2014-08-21T10:05:26Z [Term] id: GO:1903358 name: regulation of Golgi organization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of Golgi organization." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:17562788] synonym: "regulation of Golgi organisation" EXACT [GOC:TermGenie] synonym: "regulation of Golgi organization and biogenesis" RELATED [GOC:TermGenie] is_a: GO:0033043 ! regulation of organelle organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0007030 ! regulates Golgi organization relationship: RO:0002211 GO:0007030 ! regulates Golgi organization creation_date: 2014-08-21T10:22:22Z [Term] id: GO:1903375 name: facioacoustic ganglion development namespace: biological_process def: "The process whose specific outcome is the progression of an acoustico-facial VII-VIII ganglion complex over time, from its formation to the mature structure." [GO_REF:0000094, GOC:bf, GOC:mat, GOC:PARL, GOC:TermGenie, PMID:18356247] synonym: "acoustico-facial VII-VIII ganglion complex development" EXACT [UBERON:0012175] synonym: "acousticofacial ganglion development" EXACT [GOC:TermGenie] synonym: "facio-acoustic ganglion complex VII-VIII development" EXACT [GOC:TermGenie] synonym: "facio-acoustic ganglion development" EXACT [GOC:TermGenie] synonym: "facio-acoustic VII-VIII ganglion complex development" EXACT [GOC:TermGenie] is_a: GO:0061550 ! cranial ganglion development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0012175 ! results in development of acoustico-facial VII-VIII ganglion complex relationship: RO:0002296 UBERON:0012175 ! results in development of acoustico-facial VII-VIII ganglion complex creation_date: 2014-08-26T12:40:36Z [Term] id: GO:1903379 name: regulation of mitotic chromosome condensation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of mitotic chromosome condensation." [GO_REF:0000058, GOC:TermGenie, PMID:9490640] is_a: GO:0010564 ! regulation of cell cycle process is_a: GO:0060623 ! regulation of chromosome condensation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0007076 ! regulates mitotic chromosome condensation relationship: RO:0002211 GO:0007076 ! regulates mitotic chromosome condensation creation_date: 2014-08-26T13:57:13Z [Term] id: GO:1903380 name: positive regulation of mitotic chromosome condensation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of mitotic chromosome condensation." [GO_REF:0000058, GOC:TermGenie, PMID:9490640] synonym: "activation of mitotic chromosome condensation" NARROW [GOC:TermGenie] synonym: "up regulation of mitotic chromosome condensation" EXACT [GOC:TermGenie] synonym: "up-regulation of mitotic chromosome condensation" EXACT [GOC:TermGenie] synonym: "upregulation of mitotic chromosome condensation" EXACT [GOC:TermGenie] is_a: GO:0090068 ! positive regulation of cell cycle process is_a: GO:1903379 ! regulation of mitotic chromosome condensation is_a: GO:1905821 ! positive regulation of chromosome condensation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0007076 ! positively regulates mitotic chromosome condensation relationship: RO:0002213 GO:0007076 ! positively regulates mitotic chromosome condensation creation_date: 2014-08-26T13:57:29Z [Term] id: GO:1903409 name: reactive oxygen species biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of reactive oxygen species, any molecules or ions formed by the incomplete one-electron reduction of oxygen." [GO_REF:0000068, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:24252804] synonym: "reactive oxygen species anabolism" EXACT [GOC:TermGenie] synonym: "reactive oxygen species biosynthesis" EXACT [GOC:TermGenie] synonym: "reactive oxygen species formation" EXACT [GOC:TermGenie] synonym: "reactive oxygen species generation" RELATED [PMID:24252804] synonym: "reactive oxygen species synthesis" EXACT [GOC:TermGenie] synonym: "ROS formation" RELATED [] synonym: "ROS generation" RELATED [PMID:24252804] is_a: GO:0009058 ! biosynthetic process is_a: GO:0072593 ! reactive oxygen species metabolic process intersection_of: GO:0009058 ! biosynthetic process intersection_of: RO:0004008 CHEBI:26523 ! has primary output relationship: RO:0004008 CHEBI:26523 ! has primary output creation_date: 2014-09-03T09:19:13Z [Term] id: GO:1903412 name: response to bile acid namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a bile acid stimulus." [GO_REF:0000071, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:21757002] is_a: GO:0033993 ! response to lipid is_a: GO:1901700 ! response to oxygen-containing compound intersection_of: GO:0050896 ! response to stimulus intersection_of: RO:0004009 CHEBI:3098 ! has primary input relationship: RO:0004009 CHEBI:3098 ! has primary input creation_date: 2014-09-03T12:45:43Z [Term] id: GO:1903413 name: cellular response to bile acid namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a bile acid stimulus." [GO_REF:0000071, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:21757002] is_a: GO:0071396 ! cellular response to lipid is_a: GO:1901701 ! cellular response to oxygen-containing compound is_a: GO:1903412 ! response to bile acid intersection_of: GO:0070887 ! cellular response to chemical stimulus intersection_of: RO:0004009 CHEBI:3098 ! has primary input creation_date: 2014-09-03T12:45:51Z [Term] id: GO:1903426 name: regulation of reactive oxygen species biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of reactive oxygen species biosynthetic process." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:24252804] synonym: "regulation of reactive oxygen species anabolism" EXACT [GOC:TermGenie] synonym: "regulation of reactive oxygen species biosynthesis" EXACT [GOC:TermGenie] synonym: "regulation of reactive oxygen species formation" EXACT [GOC:TermGenie] synonym: "regulation of reactive oxygen species generation" RELATED [GOC:TermGenie] synonym: "regulation of reactive oxygen species synthesis" EXACT [GOC:TermGenie] synonym: "regulation of ROS formation" RELATED [GOC:TermGenie] synonym: "regulation of ROS generation" RELATED [GOC:TermGenie] is_a: GO:0009889 ! regulation of biosynthetic process is_a: GO:2000377 ! regulation of reactive oxygen species metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:1903409 ! regulates reactive oxygen species biosynthetic process relationship: RO:0002211 GO:1903409 ! regulates reactive oxygen species biosynthetic process creation_date: 2014-09-11T10:01:47Z [Term] id: GO:1903427 name: negative regulation of reactive oxygen species biosynthetic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of reactive oxygen species biosynthetic process." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:24252804] synonym: "down regulation of reactive oxygen species anabolism" EXACT [GOC:TermGenie] synonym: "down regulation of reactive oxygen species biosynthesis" EXACT [GOC:TermGenie] synonym: "down regulation of reactive oxygen species biosynthetic process" EXACT [GOC:TermGenie] synonym: "down regulation of reactive oxygen species formation" EXACT [GOC:TermGenie] synonym: "down regulation of reactive oxygen species generation" RELATED [GOC:TermGenie] synonym: "down regulation of reactive oxygen species synthesis" EXACT [GOC:TermGenie] synonym: "down regulation of ROS formation" RELATED [GOC:TermGenie] synonym: "down regulation of ROS generation" RELATED [GOC:TermGenie] synonym: "down-regulation of reactive oxygen species anabolism" EXACT [GOC:TermGenie] synonym: "down-regulation of reactive oxygen species biosynthesis" EXACT [GOC:TermGenie] synonym: "down-regulation of reactive oxygen species biosynthetic process" EXACT [GOC:TermGenie] synonym: "down-regulation of reactive oxygen species formation" EXACT [GOC:TermGenie] synonym: "down-regulation of reactive oxygen species generation" RELATED [GOC:TermGenie] synonym: "down-regulation of reactive oxygen species synthesis" EXACT [GOC:TermGenie] synonym: "down-regulation of ROS formation" RELATED [GOC:TermGenie] synonym: "down-regulation of ROS generation" RELATED [GOC:TermGenie] synonym: "downregulation of reactive oxygen species anabolism" EXACT [GOC:TermGenie] synonym: "downregulation of reactive oxygen species biosynthesis" EXACT [GOC:TermGenie] synonym: "downregulation of reactive oxygen species biosynthetic process" EXACT [GOC:TermGenie] synonym: "downregulation of reactive oxygen species formation" EXACT [GOC:TermGenie] synonym: "downregulation of reactive oxygen species generation" RELATED [GOC:TermGenie] synonym: "downregulation of reactive oxygen species synthesis" EXACT [GOC:TermGenie] synonym: "downregulation of ROS formation" RELATED [GOC:TermGenie] synonym: "downregulation of ROS generation" RELATED [GOC:TermGenie] synonym: "inhibition of reactive oxygen species anabolism" NARROW [GOC:TermGenie] synonym: "inhibition of reactive oxygen species biosynthesis" NARROW [GOC:TermGenie] synonym: "inhibition of reactive oxygen species biosynthetic process" NARROW [GOC:TermGenie] synonym: "inhibition of reactive oxygen species formation" NARROW [GOC:TermGenie] synonym: "inhibition of reactive oxygen species generation" RELATED [GOC:TermGenie] synonym: "inhibition of reactive oxygen species synthesis" NARROW [GOC:TermGenie] synonym: "inhibition of ROS formation" RELATED [GOC:TermGenie] synonym: "inhibition of ROS generation" RELATED [GOC:TermGenie] synonym: "negative regulation of reactive oxygen species anabolism" EXACT [GOC:TermGenie] synonym: "negative regulation of reactive oxygen species biosynthesis" EXACT [GOC:TermGenie] synonym: "negative regulation of reactive oxygen species formation" EXACT [GOC:TermGenie] synonym: "negative regulation of reactive oxygen species generation" RELATED [GOC:TermGenie] synonym: "negative regulation of reactive oxygen species synthesis" EXACT [GOC:TermGenie] synonym: "negative regulation of ROS formation" RELATED [GOC:TermGenie] synonym: "negative regulation of ROS generation" RELATED [GOC:TermGenie] synonym: "prevention of ROS generation" EXACT [PMID:24252804] is_a: GO:0009890 ! negative regulation of biosynthetic process is_a: GO:1903426 ! regulation of reactive oxygen species biosynthetic process is_a: GO:2000378 ! negative regulation of reactive oxygen species metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:1903409 ! negatively regulates reactive oxygen species biosynthetic process relationship: RO:0002212 GO:1903409 ! negatively regulates reactive oxygen species biosynthetic process creation_date: 2014-09-11T10:01:56Z [Term] id: GO:1903428 name: positive regulation of reactive oxygen species biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of reactive oxygen species biosynthetic process." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:24252804] synonym: "activation of reactive oxygen species anabolism" NARROW [GOC:TermGenie] synonym: "activation of reactive oxygen species biosynthesis" NARROW [GOC:TermGenie] synonym: "activation of reactive oxygen species biosynthetic process" NARROW [GOC:TermGenie] synonym: "activation of reactive oxygen species formation" NARROW [GOC:TermGenie] synonym: "activation of reactive oxygen species generation" RELATED [GOC:TermGenie] synonym: "activation of reactive oxygen species synthesis" NARROW [GOC:TermGenie] synonym: "activation of ROS formation" RELATED [GOC:TermGenie] synonym: "activation of ROS generation" RELATED [GOC:TermGenie] synonym: "positive regulation of reactive oxygen species anabolism" EXACT [GOC:TermGenie] synonym: "positive regulation of reactive oxygen species biosynthesis" EXACT [GOC:TermGenie] synonym: "positive regulation of reactive oxygen species formation" EXACT [GOC:TermGenie] synonym: "positive regulation of reactive oxygen species generation" RELATED [GOC:TermGenie] synonym: "positive regulation of reactive oxygen species synthesis" EXACT [GOC:TermGenie] synonym: "positive regulation of ROS formation" RELATED [GOC:TermGenie] synonym: "positive regulation of ROS generation" RELATED [GOC:TermGenie] synonym: "up regulation of reactive oxygen species anabolism" EXACT [GOC:TermGenie] synonym: "up regulation of reactive oxygen species biosynthesis" EXACT [GOC:TermGenie] synonym: "up regulation of reactive oxygen species biosynthetic process" EXACT [GOC:TermGenie] synonym: "up regulation of reactive oxygen species formation" EXACT [GOC:TermGenie] synonym: "up regulation of reactive oxygen species generation" RELATED [GOC:TermGenie] synonym: "up regulation of reactive oxygen species synthesis" EXACT [GOC:TermGenie] synonym: "up regulation of ROS formation" RELATED [GOC:TermGenie] synonym: "up regulation of ROS generation" RELATED [GOC:TermGenie] synonym: "up-regulation of reactive oxygen species anabolism" EXACT [GOC:TermGenie] synonym: "up-regulation of reactive oxygen species biosynthesis" EXACT [GOC:TermGenie] synonym: "up-regulation of reactive oxygen species biosynthetic process" EXACT [GOC:TermGenie] synonym: "up-regulation of reactive oxygen species formation" EXACT [GOC:TermGenie] synonym: "up-regulation of reactive oxygen species generation" RELATED [GOC:TermGenie] synonym: "up-regulation of reactive oxygen species synthesis" EXACT [GOC:TermGenie] synonym: "up-regulation of ROS formation" RELATED [GOC:TermGenie] synonym: "up-regulation of ROS generation" RELATED [GOC:TermGenie] synonym: "upregulation of reactive oxygen species anabolism" EXACT [GOC:TermGenie] synonym: "upregulation of reactive oxygen species biosynthesis" EXACT [GOC:TermGenie] synonym: "upregulation of reactive oxygen species biosynthetic process" EXACT [GOC:TermGenie] synonym: "upregulation of reactive oxygen species formation" EXACT [GOC:TermGenie] synonym: "upregulation of reactive oxygen species generation" RELATED [GOC:TermGenie] synonym: "upregulation of reactive oxygen species synthesis" EXACT [GOC:TermGenie] synonym: "upregulation of ROS formation" RELATED [GOC:TermGenie] synonym: "upregulation of ROS generation" RELATED [GOC:TermGenie] is_a: GO:0009891 ! positive regulation of biosynthetic process is_a: GO:1903426 ! regulation of reactive oxygen species biosynthetic process is_a: GO:2000379 ! positive regulation of reactive oxygen species metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:1903409 ! positively regulates reactive oxygen species biosynthetic process relationship: RO:0002213 GO:1903409 ! positively regulates reactive oxygen species biosynthetic process creation_date: 2014-09-11T10:02:05Z [Term] id: GO:1903429 name: regulation of cell maturation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cell maturation." [GO_REF:0000058, GOC:TermGenie, PMID:17459944] synonym: "regulation of functional differentiation" RELATED [GOC:TermGenie] is_a: GO:0060284 ! regulation of cell development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0048469 ! regulates cell maturation relationship: RO:0002211 GO:0048469 ! regulates cell maturation creation_date: 2014-09-15T13:31:23Z [Term] id: GO:1903430 name: negative regulation of cell maturation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of cell maturation." [GO_REF:0000058, GOC:TermGenie, PMID:17459944] synonym: "down regulation of cell maturation" EXACT [GOC:TermGenie] synonym: "down regulation of functional differentiation" RELATED [GOC:TermGenie] synonym: "down-regulation of cell maturation" EXACT [GOC:TermGenie] synonym: "down-regulation of functional differentiation" RELATED [GOC:TermGenie] synonym: "downregulation of cell maturation" EXACT [GOC:TermGenie] synonym: "downregulation of functional differentiation" RELATED [GOC:TermGenie] synonym: "inhibition of cell maturation" NARROW [GOC:TermGenie] synonym: "inhibition of functional differentiation" RELATED [GOC:TermGenie] synonym: "negative regulation of functional differentiation" RELATED [GOC:TermGenie] is_a: GO:0010721 ! negative regulation of cell development is_a: GO:1903429 ! regulation of cell maturation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0048469 ! negatively regulates cell maturation relationship: RO:0002212 GO:0048469 ! negatively regulates cell maturation creation_date: 2014-09-15T13:31:32Z [Term] id: GO:1903431 name: positive regulation of cell maturation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cell maturation." [GO_REF:0000058, GOC:TermGenie, PMID:17459944] synonym: "activation of cell maturation" NARROW [GOC:TermGenie] synonym: "activation of functional differentiation" RELATED [GOC:TermGenie] synonym: "positive regulation of functional differentiation" RELATED [GOC:TermGenie] synonym: "up regulation of cell maturation" EXACT [GOC:TermGenie] synonym: "up regulation of functional differentiation" RELATED [GOC:TermGenie] synonym: "up-regulation of cell maturation" EXACT [GOC:TermGenie] synonym: "up-regulation of functional differentiation" RELATED [GOC:TermGenie] synonym: "upregulation of cell maturation" EXACT [GOC:TermGenie] synonym: "upregulation of functional differentiation" RELATED [GOC:TermGenie] is_a: GO:0010720 ! positive regulation of cell development is_a: GO:1903429 ! regulation of cell maturation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0048469 ! positively regulates cell maturation relationship: RO:0002213 GO:0048469 ! positively regulates cell maturation creation_date: 2014-09-15T13:31:41Z [Term] id: GO:1903439 name: calcitonin family receptor complex namespace: cellular_component def: "A protein complex which is capable of calcitonin family receptor activity. Calcitonin family receptors may form dimers, trimers or tetramers; adrenomedullin and amylin receptors have only been observed as dimers so far." [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:10871296, PMID:12037140, PMID:18687416] is_a: GO:0097648 ! G protein-coupled receptor complex intersection_of: GO:0032991 ! protein-containing complex intersection_of: RO:0002215 GO:0097642 ! capable of calcitonin family receptor activity relationship: RO:0002215 GO:0097642 ! capable of calcitonin family receptor activity creation_date: 2014-09-16T13:25:11Z [Term] id: GO:1903441 name: protein localization to ciliary membrane namespace: biological_process def: "A process in which a protein is transported to, or maintained in, a location within a ciliary membrane." [GO_REF:0000087, GOC:cilia, GOC:krc, GOC:TermGenie, PMID:22139371] synonym: "protein localisation in ciliary membrane" EXACT [GOC:TermGenie] synonym: "protein localisation to ciliary membrane" EXACT [GOC:TermGenie] synonym: "protein localization in ciliary membrane" EXACT [GOC:TermGenie] is_a: GO:0061512 ! protein localization to cilium is_a: GO:0072657 ! protein localization to membrane is_a: GO:1990778 ! protein localization to cell periphery intersection_of: GO:0008104 ! intracellular protein localization intersection_of: RO:0002339 GO:0060170 ! has target end location ciliary membrane relationship: RO:0002339 GO:0060170 ! has target end location ciliary membrane property_value: RO:0002161 NCBITaxon:3176 property_value: RO:0002161 NCBITaxon:3378 property_value: RO:0002161 NCBITaxon:3398 property_value: RO:0002161 NCBITaxon:4890 property_value: RO:0002161 NCBITaxon:5782 creation_date: 2014-09-16T15:15:39Z [Term] id: GO:1903444 name: negative regulation of brown fat cell differentiation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of brown fat cell differentiation." [GO_REF:0000058, GOC:TermGenie, PMID:23977283] synonym: "down regulation of brown adipocyte cell differentiation" EXACT [GOC:TermGenie] synonym: "down regulation of brown adipocyte differentiation" EXACT [GOC:TermGenie] synonym: "down regulation of brown fat cell differentiation" EXACT [GOC:TermGenie] synonym: "down-regulation of brown adipocyte cell differentiation" EXACT [GOC:TermGenie] synonym: "down-regulation of brown adipocyte differentiation" EXACT [GOC:TermGenie] synonym: "down-regulation of brown fat cell differentiation" EXACT [GOC:TermGenie] synonym: "downregulation of brown adipocyte cell differentiation" EXACT [GOC:TermGenie] synonym: "downregulation of brown adipocyte differentiation" EXACT [GOC:TermGenie] synonym: "downregulation of brown fat cell differentiation" EXACT [GOC:TermGenie] synonym: "inhibition of brown adipocyte cell differentiation" NARROW [GOC:TermGenie] synonym: "inhibition of brown adipocyte differentiation" NARROW [GOC:TermGenie] synonym: "inhibition of brown fat cell differentiation" NARROW [GOC:TermGenie] synonym: "negative regulation of brown adipocyte cell differentiation" EXACT [GOC:TermGenie] synonym: "negative regulation of brown adipocyte differentiation" EXACT [GOC:TermGenie] is_a: GO:0045599 ! negative regulation of fat cell differentiation is_a: GO:0090335 ! regulation of brown fat cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0050873 ! negatively regulates brown fat cell differentiation relationship: RO:0002212 GO:0050873 ! negatively regulates brown fat cell differentiation property_value: RO:0002161 NCBITaxon:8782 creation_date: 2014-09-17T19:15:00Z [Term] id: GO:1903487 name: regulation of lactation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of lactation." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:19563620] is_a: GO:0050878 ! regulation of body fluid levels is_a: GO:0051046 ! regulation of secretion is_a: GO:2000026 ! regulation of multicellular organismal development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0007595 ! regulates lactation relationship: RO:0002211 GO:0007595 ! regulates lactation creation_date: 2014-09-24T14:44:13Z [Term] id: GO:1903488 name: negative regulation of lactation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of lactation." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:19563620] synonym: "down regulation of lactation" EXACT [GOC:TermGenie] synonym: "down-regulation of lactation" EXACT [GOC:TermGenie] synonym: "downregulation of lactation" EXACT [GOC:TermGenie] synonym: "inhibition of lactation" NARROW [GOC:TermGenie] is_a: GO:0051048 ! negative regulation of secretion is_a: GO:0051093 ! negative regulation of developmental process is_a: GO:0051241 ! negative regulation of multicellular organismal process is_a: GO:1903487 ! regulation of lactation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0007595 ! negatively regulates lactation relationship: RO:0002212 GO:0007595 ! negatively regulates lactation creation_date: 2014-09-24T14:44:22Z [Term] id: GO:1903489 name: positive regulation of lactation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of lactation." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:19563620] synonym: "activation of lactation" NARROW [GOC:TermGenie] synonym: "up regulation of lactation" EXACT [GOC:TermGenie] synonym: "up-regulation of lactation" EXACT [GOC:TermGenie] synonym: "upregulation of lactation" EXACT [GOC:TermGenie] is_a: GO:0051047 ! positive regulation of secretion is_a: GO:0051094 ! positive regulation of developmental process is_a: GO:0051240 ! positive regulation of multicellular organismal process is_a: GO:1903487 ! regulation of lactation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0007595 ! positively regulates lactation relationship: RO:0002213 GO:0007595 ! positively regulates lactation creation_date: 2014-09-24T14:44:30Z [Term] id: GO:1903509 name: liposaccharide metabolic process namespace: biological_process def: "The chemical reactions and pathways involving liposaccharide." [GO_REF:0000068, GOC:dph, GOC:TermGenie, PMID:9452964] synonym: "liposaccharide metabolism" EXACT [GOC:TermGenie] is_a: GO:0006629 ! lipid metabolic process is_a: GO:1901135 ! carbohydrate derivative metabolic process intersection_of: GO:0008152 ! metabolic process intersection_of: RO:0004007 CHEBI:35740 ! has primary input or output relationship: RO:0004007 CHEBI:35740 ! has primary input or output creation_date: 2014-10-01T21:52:52Z [Term] id: GO:1903522 name: regulation of blood circulation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of blood circulation." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:10659969] synonym: "regulation of hemolymph circulation" RELATED [GOC:TermGenie] is_a: GO:0044057 ! regulation of system process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0008015 ! regulates blood circulation relationship: RO:0002211 GO:0008015 ! regulates blood circulation property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 creation_date: 2014-10-06T18:38:56Z [Term] id: GO:1903523 name: negative regulation of blood circulation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of blood circulation." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:10659969] synonym: "down regulation of blood circulation" EXACT [GOC:TermGenie] synonym: "down regulation of hemolymph circulation" RELATED [GOC:TermGenie] synonym: "down-regulation of blood circulation" EXACT [GOC:TermGenie] synonym: "down-regulation of hemolymph circulation" RELATED [GOC:TermGenie] synonym: "downregulation of blood circulation" EXACT [GOC:TermGenie] synonym: "downregulation of hemolymph circulation" RELATED [GOC:TermGenie] synonym: "inhibition of blood circulation" NARROW [GOC:TermGenie] synonym: "inhibition of hemolymph circulation" RELATED [GOC:TermGenie] synonym: "negative regulation of hemolymph circulation" RELATED [GOC:TermGenie] is_a: GO:0051241 ! negative regulation of multicellular organismal process is_a: GO:1903522 ! regulation of blood circulation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0008015 ! negatively regulates blood circulation relationship: RO:0002212 GO:0008015 ! negatively regulates blood circulation property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 creation_date: 2014-10-06T18:39:05Z [Term] id: GO:1903524 name: positive regulation of blood circulation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of blood circulation." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:10659969] synonym: "activation of blood circulation" NARROW [GOC:TermGenie] synonym: "activation of hemolymph circulation" RELATED [GOC:TermGenie] synonym: "positive regulation of hemolymph circulation" RELATED [GOC:TermGenie] synonym: "up regulation of blood circulation" EXACT [GOC:TermGenie] synonym: "up regulation of hemolymph circulation" RELATED [GOC:TermGenie] synonym: "up-regulation of blood circulation" EXACT [GOC:TermGenie] synonym: "up-regulation of hemolymph circulation" RELATED [GOC:TermGenie] synonym: "upregulation of blood circulation" EXACT [GOC:TermGenie] synonym: "upregulation of hemolymph circulation" RELATED [GOC:TermGenie] is_a: GO:0051240 ! positive regulation of multicellular organismal process is_a: GO:1903522 ! regulation of blood circulation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0008015 ! positively regulates blood circulation relationship: RO:0002213 GO:0008015 ! positively regulates blood circulation property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 creation_date: 2014-10-06T18:39:13Z [Term] id: GO:1903530 name: regulation of secretion by cell namespace: biological_process def: "Any process that modulates the frequency, rate or extent of secretion by cell." [GO_REF:0000058, GOC:pm, GOC:TermGenie, PMID:12130530] synonym: "regulation of cellular secretion" EXACT [GOC:TermGenie] is_a: GO:0050794 ! regulation of cellular process is_a: GO:0051046 ! regulation of secretion intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0032940 ! regulates secretion by cell relationship: RO:0002211 GO:0032940 ! regulates secretion by cell creation_date: 2014-10-08T13:24:59Z [Term] id: GO:1903531 name: negative regulation of secretion by cell namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of secretion by cell." [GO_REF:0000058, GOC:pm, GOC:TermGenie, PMID:12130530] synonym: "down regulation of cellular secretion" EXACT [GOC:TermGenie] synonym: "down regulation of secretion by cell" EXACT [GOC:TermGenie] synonym: "down-regulation of cellular secretion" EXACT [GOC:TermGenie] synonym: "down-regulation of secretion by cell" EXACT [GOC:TermGenie] synonym: "downregulation of cellular secretion" EXACT [GOC:TermGenie] synonym: "downregulation of secretion by cell" EXACT [GOC:TermGenie] synonym: "inhibition of cellular secretion" NARROW [GOC:TermGenie] synonym: "inhibition of secretion by cell" NARROW [GOC:TermGenie] synonym: "negative regulation of cellular secretion" EXACT [GOC:TermGenie] is_a: GO:0048523 ! negative regulation of cellular process is_a: GO:0051048 ! negative regulation of secretion is_a: GO:1903530 ! regulation of secretion by cell intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0032940 ! negatively regulates secretion by cell relationship: RO:0002212 GO:0032940 ! negatively regulates secretion by cell creation_date: 2014-10-08T13:25:08Z [Term] id: GO:1903532 name: positive regulation of secretion by cell namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of secretion by cell." [GO_REF:0000058, GOC:pm, GOC:TermGenie, PMID:12130530] synonym: "activation of cellular secretion" NARROW [GOC:TermGenie] synonym: "activation of secretion by cell" NARROW [GOC:TermGenie] synonym: "positive regulation of cellular secretion" EXACT [GOC:TermGenie] synonym: "up regulation of cellular secretion" EXACT [GOC:TermGenie] synonym: "up regulation of secretion by cell" EXACT [GOC:TermGenie] synonym: "up-regulation of cellular secretion" EXACT [GOC:TermGenie] synonym: "up-regulation of secretion by cell" EXACT [GOC:TermGenie] synonym: "upregulation of cellular secretion" EXACT [GOC:TermGenie] synonym: "upregulation of secretion by cell" EXACT [GOC:TermGenie] is_a: GO:0048522 ! positive regulation of cellular process is_a: GO:0051047 ! positive regulation of secretion is_a: GO:1903530 ! regulation of secretion by cell intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0032940 ! positively regulates secretion by cell relationship: RO:0002213 GO:0032940 ! positively regulates secretion by cell creation_date: 2014-10-08T13:25:17Z [Term] id: GO:1903537 name: meiotic cell cycle process involved in oocyte maturation namespace: biological_process def: "Any meiotic cell cycle process that is involved in oocyte maturation." [GO_REF:0000060, GOC:jz, GOC:TermGenie, PMID:25212395] synonym: "meiosis involved in oocyte maturation" BROAD [] is_a: GO:1903046 ! meiotic cell cycle process intersection_of: GO:1903046 ! meiotic cell cycle process intersection_of: BFO:0000050 GO:0001556 ! part of oocyte maturation relationship: BFO:0000050 GO:0001556 ! part of oocyte maturation creation_date: 2014-10-09T10:46:14Z [Term] id: GO:1903538 name: regulation of meiotic cell cycle process involved in oocyte maturation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of meiotic cell cycle process involved in oocyte maturation." [GO_REF:0000058, GOC:jz, GOC:TermGenie, PMID:25212395] synonym: "regulation of meiosis involved in oocyte maturation" BROAD [GOC:TermGenie] is_a: GO:0010564 ! regulation of cell cycle process is_a: GO:2000241 ! regulation of reproductive process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:1903537 ! regulates meiotic cell cycle process involved in oocyte maturation relationship: RO:0002211 GO:1903537 ! regulates meiotic cell cycle process involved in oocyte maturation creation_date: 2014-10-09T10:52:38Z [Term] id: GO:1903539 name: protein localization to postsynaptic membrane namespace: biological_process def: "A process in which a protein is transported to, or maintained in, a location within a postsynaptic membrane." [GO_REF:0000087, GOC:kmv, GOC:TermGenie, PMID:9753322] synonym: "protein localisation in postsynaptic membrane" EXACT [GOC:TermGenie] synonym: "protein localisation to postsynaptic membrane" EXACT [GOC:TermGenie] synonym: "protein localization in postsynaptic membrane" EXACT [GOC:TermGenie] is_a: GO:0062237 ! protein localization to postsynapse is_a: GO:0072657 ! protein localization to membrane is_a: GO:1990778 ! protein localization to cell periphery intersection_of: GO:0008104 ! intracellular protein localization intersection_of: RO:0002339 GO:0045211 ! has target end location postsynaptic membrane relationship: RO:0002339 GO:0045211 ! has target end location postsynaptic membrane creation_date: 2014-10-10T11:23:53Z [Term] id: GO:1903540 name: establishment of protein localization to postsynaptic membrane namespace: biological_process def: "The directed movement of a protein to a specific location in a postsynaptic membrane." [GO_REF:0000087, GOC:kmv, GOC:TermGenie, PMID:9753322] synonym: "establishment of protein localisation in postsynaptic membrane" EXACT [GOC:TermGenie] synonym: "establishment of protein localisation to postsynaptic membrane" EXACT [GOC:TermGenie] synonym: "establishment of protein localization in postsynaptic membrane" EXACT [GOC:TermGenie] is_a: GO:0090150 ! establishment of protein localization to membrane intersection_of: GO:0045184 ! establishment of protein localization intersection_of: RO:0002339 GO:0045211 ! has target end location postsynaptic membrane relationship: RO:0002339 GO:0045211 ! has target end location postsynaptic membrane creation_date: 2014-10-10T11:24:03Z [Term] id: GO:1903541 name: regulation of exosomal secretion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of exosomal secretion." [GO_REF:0000058, GOC:TermGenie, PMID:24105262] synonym: "regulation of exosomal protein secretion" NARROW [GOC:TermGenie] synonym: "regulation of exosomal secretory pathway" EXACT [GOC:TermGenie] synonym: "regulation of extracellular vesicular exosome secretion" EXACT [GOC:TermGenie] synonym: "regulation of secretion of exosome" EXACT [GOC:TermGenie] is_a: GO:0017157 ! regulation of exocytosis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:1990182 ! regulates exosomal secretion relationship: RO:0002211 GO:1990182 ! regulates exosomal secretion property_value: RO:0002161 NCBITaxon:4890 creation_date: 2014-10-14T11:38:52Z [Term] id: GO:1903542 name: negative regulation of exosomal secretion namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of exosomal secretion." [GO_REF:0000058, GOC:TermGenie, PMID:24105262] synonym: "down regulation of exosomal protein secretion" NARROW [GOC:TermGenie] synonym: "down regulation of exosomal secretion" EXACT [GOC:TermGenie] synonym: "down regulation of exosomal secretory pathway" EXACT [GOC:TermGenie] synonym: "down regulation of extracellular vesicular exosome secretion" EXACT [GOC:TermGenie] synonym: "down regulation of secretion of exosome" EXACT [GOC:TermGenie] synonym: "down-regulation of exosomal protein secretion" NARROW [GOC:TermGenie] synonym: "down-regulation of exosomal secretion" EXACT [GOC:TermGenie] synonym: "down-regulation of exosomal secretory pathway" EXACT [GOC:TermGenie] synonym: "down-regulation of extracellular vesicular exosome secretion" EXACT [GOC:TermGenie] synonym: "down-regulation of secretion of exosome" EXACT [GOC:TermGenie] synonym: "downregulation of exosomal protein secretion" NARROW [GOC:TermGenie] synonym: "downregulation of exosomal secretion" EXACT [GOC:TermGenie] synonym: "downregulation of exosomal secretory pathway" EXACT [GOC:TermGenie] synonym: "downregulation of extracellular vesicular exosome secretion" EXACT [GOC:TermGenie] synonym: "downregulation of secretion of exosome" EXACT [GOC:TermGenie] synonym: "inhibition of exosomal protein secretion" NARROW [GOC:TermGenie] synonym: "inhibition of exosomal secretion" NARROW [GOC:TermGenie] synonym: "inhibition of exosomal secretory pathway" NARROW [GOC:TermGenie] synonym: "inhibition of extracellular vesicular exosome secretion" NARROW [GOC:TermGenie] synonym: "inhibition of secretion of exosome" NARROW [GOC:TermGenie] synonym: "negative regulation of exosomal protein secretion" NARROW [GOC:TermGenie] synonym: "negative regulation of exosomal secretory pathway" EXACT [GOC:TermGenie] synonym: "negative regulation of extracellular vesicular exosome secretion" EXACT [GOC:TermGenie] synonym: "negative regulation of secretion of exosome" EXACT [GOC:TermGenie] is_a: GO:0045920 ! negative regulation of exocytosis is_a: GO:1903541 ! regulation of exosomal secretion intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:1990182 ! negatively regulates exosomal secretion relationship: RO:0002212 GO:1990182 ! negatively regulates exosomal secretion property_value: RO:0002161 NCBITaxon:4890 creation_date: 2014-10-14T11:39:02Z [Term] id: GO:1903543 name: positive regulation of exosomal secretion namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of exosomal secretion." [GO_REF:0000058, GOC:TermGenie, PMID:24105262] synonym: "activation of exosomal protein secretion" NARROW [GOC:TermGenie] synonym: "activation of exosomal secretion" NARROW [GOC:TermGenie] synonym: "activation of exosomal secretory pathway" NARROW [GOC:TermGenie] synonym: "activation of extracellular vesicular exosome secretion" NARROW [GOC:TermGenie] synonym: "activation of secretion of exosome" NARROW [GOC:TermGenie] synonym: "positive regulation of exosomal protein secretion" NARROW [GOC:TermGenie] synonym: "positive regulation of exosomal secretory pathway" EXACT [GOC:TermGenie] synonym: "positive regulation of extracellular vesicular exosome secretion" EXACT [GOC:TermGenie] synonym: "positive regulation of secretion of exosome" EXACT [GOC:TermGenie] synonym: "up regulation of exosomal protein secretion" NARROW [GOC:TermGenie] synonym: "up regulation of exosomal secretion" EXACT [GOC:TermGenie] synonym: "up regulation of exosomal secretory pathway" EXACT [GOC:TermGenie] synonym: "up regulation of extracellular vesicular exosome secretion" EXACT [GOC:TermGenie] synonym: "up regulation of secretion of exosome" EXACT [GOC:TermGenie] synonym: "up-regulation of exosomal protein secretion" NARROW [GOC:TermGenie] synonym: "up-regulation of exosomal secretion" EXACT [GOC:TermGenie] synonym: "up-regulation of exosomal secretory pathway" EXACT [GOC:TermGenie] synonym: "up-regulation of extracellular vesicular exosome secretion" EXACT [GOC:TermGenie] synonym: "up-regulation of secretion of exosome" EXACT [GOC:TermGenie] synonym: "upregulation of exosomal protein secretion" NARROW [GOC:TermGenie] synonym: "upregulation of exosomal secretion" EXACT [GOC:TermGenie] synonym: "upregulation of exosomal secretory pathway" EXACT [GOC:TermGenie] synonym: "upregulation of extracellular vesicular exosome secretion" EXACT [GOC:TermGenie] synonym: "upregulation of secretion of exosome" EXACT [GOC:TermGenie] is_a: GO:0044089 ! positive regulation of cellular component biogenesis is_a: GO:0045921 ! positive regulation of exocytosis is_a: GO:1903541 ! regulation of exosomal secretion intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:1990182 ! positively regulates exosomal secretion relationship: RO:0002213 GO:1990182 ! positively regulates exosomal secretion property_value: RO:0002161 NCBITaxon:4890 creation_date: 2014-10-14T11:39:10Z [Term] id: GO:1903551 name: regulation of extracellular exosome assembly namespace: biological_process def: "Any process that modulates the frequency, rate or extent of extracellular vesicular exosome assembly." [GO_REF:0000058, GOC:TermGenie, PMID:24105262] synonym: "regulation of extracellular vesicular exosome assembly" EXACT [GOC:vesicles] is_a: GO:1902115 ! regulation of organelle assembly intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0071971 ! regulates extracellular exosome assembly relationship: RO:0002211 GO:0071971 ! regulates extracellular exosome assembly property_value: RO:0002161 NCBITaxon:4890 creation_date: 2014-10-20T15:37:25Z [Term] id: GO:1903552 name: negative regulation of extracellular exosome assembly namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of extracellular vesicular exosome assembly." [GO_REF:0000058, GOC:TermGenie, PMID:24105262] synonym: "down regulation of extracellular vesicular exosome assembly" EXACT [GOC:TermGenie] synonym: "down-regulation of extracellular vesicular exosome assembly" EXACT [GOC:TermGenie] synonym: "downregulation of extracellular vesicular exosome assembly" EXACT [GOC:TermGenie] synonym: "inhibition of extracellular vesicular exosome assembly" NARROW [GOC:TermGenie] synonym: "negative regulation of extracellular vesicular exosome assembly" EXACT [GOC:vesicles] is_a: GO:1902116 ! negative regulation of organelle assembly is_a: GO:1903551 ! regulation of extracellular exosome assembly intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0071971 ! negatively regulates extracellular exosome assembly relationship: RO:0002212 GO:0071971 ! negatively regulates extracellular exosome assembly property_value: RO:0002161 NCBITaxon:4890 creation_date: 2014-10-20T15:37:33Z [Term] id: GO:1903553 name: positive regulation of extracellular exosome assembly namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of extracellular vesicular exosome assembly." [GO_REF:0000058, GOC:TermGenie, PMID:24105262] synonym: "activation of extracellular vesicular exosome assembly" NARROW [GOC:TermGenie] synonym: "positive regulation of extracellular vesicular exosome assembly" RELATED [GOC:vesicles] synonym: "up regulation of extracellular vesicular exosome assembly" EXACT [GOC:TermGenie] synonym: "up-regulation of extracellular vesicular exosome assembly" EXACT [GOC:TermGenie] synonym: "upregulation of extracellular vesicular exosome assembly" EXACT [GOC:TermGenie] is_a: GO:1902117 ! positive regulation of organelle assembly is_a: GO:1903551 ! regulation of extracellular exosome assembly intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0071971 ! positively regulates extracellular exosome assembly relationship: RO:0002213 GO:0071971 ! positively regulates extracellular exosome assembly property_value: RO:0002161 NCBITaxon:4890 creation_date: 2014-10-20T15:37:42Z [Term] id: GO:1903555 name: regulation of tumor necrosis factor superfamily cytokine production namespace: biological_process def: "Any process that modulates the frequency, rate or extent of tumor necrosis factor superfamily cytokine production." [GO_REF:0000058, GOC:TermGenie, PMID:24187568] synonym: "regulation of TNF superfamily production" RELATED [GOC:TermGenie] synonym: "regulation of TNFSF cytokine production" EXACT [GOC:TermGenie] is_a: GO:0001817 ! regulation of cytokine production intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0071706 ! regulates tumor necrosis factor superfamily cytokine production relationship: RO:0002211 GO:0071706 ! regulates tumor necrosis factor superfamily cytokine production property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 creation_date: 2014-10-21T10:26:05Z [Term] id: GO:1903556 name: negative regulation of tumor necrosis factor superfamily cytokine production namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of tumor necrosis factor superfamily cytokine production." [GO_REF:0000058, GOC:TermGenie, PMID:24187568] synonym: "down regulation of TNF superfamily production" RELATED [GOC:TermGenie] synonym: "down regulation of TNFSF cytokine production" EXACT [GOC:TermGenie] synonym: "down regulation of tumor necrosis factor superfamily cytokine production" EXACT [GOC:TermGenie] synonym: "down-regulation of TNF superfamily production" RELATED [GOC:TermGenie] synonym: "down-regulation of TNFSF cytokine production" EXACT [GOC:TermGenie] synonym: "down-regulation of tumor necrosis factor superfamily cytokine production" EXACT [GOC:TermGenie] synonym: "downregulation of TNF superfamily production" RELATED [GOC:TermGenie] synonym: "downregulation of TNFSF cytokine production" EXACT [GOC:TermGenie] synonym: "downregulation of tumor necrosis factor superfamily cytokine production" EXACT [GOC:TermGenie] synonym: "inhibition of TNF superfamily production" RELATED [GOC:TermGenie] synonym: "inhibition of TNFSF cytokine production" NARROW [GOC:TermGenie] synonym: "inhibition of tumor necrosis factor superfamily cytokine production" NARROW [GOC:TermGenie] synonym: "negative regulation of TNF superfamily production" RELATED [GOC:TermGenie] synonym: "negative regulation of TNFSF cytokine production" EXACT [GOC:TermGenie] is_a: GO:0001818 ! negative regulation of cytokine production is_a: GO:1903555 ! regulation of tumor necrosis factor superfamily cytokine production intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0071706 ! negatively regulates tumor necrosis factor superfamily cytokine production relationship: RO:0002212 GO:0071706 ! negatively regulates tumor necrosis factor superfamily cytokine production property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 creation_date: 2014-10-21T10:26:14Z [Term] id: GO:1903557 name: positive regulation of tumor necrosis factor superfamily cytokine production namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of tumor necrosis factor superfamily cytokine production." [GO_REF:0000058, GOC:TermGenie, PMID:24187568] synonym: "activation of TNF superfamily production" RELATED [GOC:TermGenie] synonym: "activation of TNFSF cytokine production" NARROW [GOC:TermGenie] synonym: "activation of tumor necrosis factor superfamily cytokine production" NARROW [GOC:TermGenie] synonym: "positive regulation of TNF superfamily production" RELATED [GOC:TermGenie] synonym: "positive regulation of TNFSF cytokine production" EXACT [GOC:TermGenie] synonym: "up regulation of TNF superfamily production" RELATED [GOC:TermGenie] synonym: "up regulation of TNFSF cytokine production" EXACT [GOC:TermGenie] synonym: "up regulation of tumor necrosis factor superfamily cytokine production" EXACT [GOC:TermGenie] synonym: "up-regulation of TNF superfamily production" RELATED [GOC:TermGenie] synonym: "up-regulation of TNFSF cytokine production" EXACT [GOC:TermGenie] synonym: "up-regulation of tumor necrosis factor superfamily cytokine production" EXACT [GOC:TermGenie] synonym: "upregulation of TNF superfamily production" RELATED [GOC:TermGenie] synonym: "upregulation of TNFSF cytokine production" EXACT [GOC:TermGenie] synonym: "upregulation of tumor necrosis factor superfamily cytokine production" EXACT [GOC:TermGenie] is_a: GO:0001819 ! positive regulation of cytokine production is_a: GO:1903555 ! regulation of tumor necrosis factor superfamily cytokine production intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0071706 ! positively regulates tumor necrosis factor superfamily cytokine production relationship: RO:0002213 GO:0071706 ! positively regulates tumor necrosis factor superfamily cytokine production property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 creation_date: 2014-10-21T10:26:23Z [Term] id: GO:1903561 name: extracellular vesicle namespace: cellular_component def: "Any vesicle that is part of the extracellular region." [GO_REF:0000064, GOC:pm, GOC:TermGenie, PMID:24769233] synonym: "microparticle" RELATED [GOC:vesicles] is_a: GO:0031982 ! vesicle is_a: GO:0065010 ! extracellular membrane-bounded organelle intersection_of: GO:0031982 ! vesicle intersection_of: BFO:0000050 GO:0005576 ! part of extracellular region creation_date: 2014-10-22T14:26:11Z [Term] id: GO:1903564 name: regulation of protein localization to cilium namespace: biological_process def: "Any process that modulates the frequency, rate or extent of protein localization to cilium." [GO_REF:0000058, GOC:cilia, GOC:krc, GOC:TermGenie, PMID:22072986] is_a: GO:0032880 ! regulation of protein localization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0061512 ! regulates protein localization to cilium relationship: RO:0002211 GO:0061512 ! regulates protein localization to cilium property_value: RO:0002161 NCBITaxon:3176 property_value: RO:0002161 NCBITaxon:3378 property_value: RO:0002161 NCBITaxon:3398 property_value: RO:0002161 NCBITaxon:4890 property_value: RO:0002161 NCBITaxon:5782 creation_date: 2014-10-24T20:58:11Z [Term] id: GO:1903565 name: negative regulation of protein localization to cilium namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to cilium." [GO_REF:0000058, GOC:cilia, GOC:krc, GOC:TermGenie, PMID:22072986] synonym: "down regulation of protein localization to cilium" EXACT [GOC:TermGenie] synonym: "down-regulation of protein localization to cilium" EXACT [GOC:TermGenie] synonym: "downregulation of protein localization to cilium" EXACT [GOC:TermGenie] synonym: "inhibition of protein localization to cilium" NARROW [GOC:TermGenie] is_a: GO:1903564 ! regulation of protein localization to cilium is_a: GO:1903828 ! negative regulation of protein localization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0061512 ! negatively regulates protein localization to cilium relationship: RO:0002212 GO:0061512 ! negatively regulates protein localization to cilium property_value: RO:0002161 NCBITaxon:3176 property_value: RO:0002161 NCBITaxon:3378 property_value: RO:0002161 NCBITaxon:3398 property_value: RO:0002161 NCBITaxon:4890 property_value: RO:0002161 NCBITaxon:5782 creation_date: 2014-10-24T20:58:20Z [Term] id: GO:1903566 name: positive regulation of protein localization to cilium namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of protein localization to cilium." [GO_REF:0000058, GOC:cilia, GOC:krc, GOC:TermGenie, PMID:22072986] synonym: "activation of protein localization to cilium" NARROW [GOC:TermGenie] synonym: "up regulation of protein localization to cilium" EXACT [GOC:TermGenie] synonym: "up-regulation of protein localization to cilium" EXACT [GOC:TermGenie] synonym: "upregulation of protein localization to cilium" EXACT [GOC:TermGenie] is_a: GO:1903564 ! regulation of protein localization to cilium is_a: GO:1903829 ! positive regulation of protein localization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0061512 ! positively regulates protein localization to cilium relationship: RO:0002213 GO:0061512 ! positively regulates protein localization to cilium property_value: RO:0002161 NCBITaxon:3176 property_value: RO:0002161 NCBITaxon:3378 property_value: RO:0002161 NCBITaxon:3398 property_value: RO:0002161 NCBITaxon:4890 property_value: RO:0002161 NCBITaxon:5782 creation_date: 2014-10-24T20:58:28Z [Term] id: GO:1903567 name: regulation of protein localization to ciliary membrane namespace: biological_process def: "Any process that modulates the frequency, rate or extent of protein localization to ciliary membrane." [GO_REF:0000058, GOC:cilia, GOC:krc, GOC:TermGenie, PMID:22072986] synonym: "regulation of protein localisation in ciliary membrane" EXACT [GOC:TermGenie] synonym: "regulation of protein localisation to ciliary membrane" EXACT [GOC:TermGenie] synonym: "regulation of protein localization in ciliary membrane" EXACT [GOC:TermGenie] is_a: GO:1903564 ! regulation of protein localization to cilium is_a: GO:1904375 ! regulation of protein localization to cell periphery is_a: GO:1905475 ! regulation of protein localization to membrane intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:1903441 ! regulates protein localization to ciliary membrane relationship: RO:0002211 GO:1903441 ! regulates protein localization to ciliary membrane property_value: RO:0002161 NCBITaxon:3176 property_value: RO:0002161 NCBITaxon:3378 property_value: RO:0002161 NCBITaxon:3398 property_value: RO:0002161 NCBITaxon:4890 property_value: RO:0002161 NCBITaxon:5782 creation_date: 2014-10-24T21:32:51Z [Term] id: GO:1903568 name: negative regulation of protein localization to ciliary membrane namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to ciliary membrane." [GO_REF:0000058, GOC:cilia, GOC:krc, GOC:TermGenie, PMID:22072986] synonym: "down regulation of protein localisation in ciliary membrane" EXACT [GOC:TermGenie] synonym: "down regulation of protein localisation to ciliary membrane" EXACT [GOC:TermGenie] synonym: "down regulation of protein localization in ciliary membrane" EXACT [GOC:TermGenie] synonym: "down regulation of protein localization to ciliary membrane" EXACT [GOC:TermGenie] synonym: "down-regulation of protein localisation in ciliary membrane" EXACT [GOC:TermGenie] synonym: "down-regulation of protein localisation to ciliary membrane" EXACT [GOC:TermGenie] synonym: "down-regulation of protein localization in ciliary membrane" EXACT [GOC:TermGenie] synonym: "down-regulation of protein localization to ciliary membrane" EXACT [GOC:TermGenie] synonym: "downregulation of protein localisation in ciliary membrane" EXACT [GOC:TermGenie] synonym: "downregulation of protein localisation to ciliary membrane" EXACT [GOC:TermGenie] synonym: "downregulation of protein localization in ciliary membrane" EXACT [GOC:TermGenie] synonym: "downregulation of protein localization to ciliary membrane" EXACT [GOC:TermGenie] synonym: "inhibition of protein localisation in ciliary membrane" NARROW [GOC:TermGenie] synonym: "inhibition of protein localisation to ciliary membrane" NARROW [GOC:TermGenie] synonym: "inhibition of protein localization in ciliary membrane" NARROW [GOC:TermGenie] synonym: "inhibition of protein localization to ciliary membrane" NARROW [GOC:TermGenie] synonym: "negative regulation of protein localisation in ciliary membrane" EXACT [GOC:TermGenie] synonym: "negative regulation of protein localisation to ciliary membrane" EXACT [GOC:TermGenie] synonym: "negative regulation of protein localization in ciliary membrane" EXACT [GOC:TermGenie] is_a: GO:1903565 ! negative regulation of protein localization to cilium is_a: GO:1903567 ! regulation of protein localization to ciliary membrane is_a: GO:1904376 ! negative regulation of protein localization to cell periphery is_a: GO:1905476 ! negative regulation of protein localization to membrane intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:1903441 ! negatively regulates protein localization to ciliary membrane relationship: RO:0002212 GO:1903441 ! negatively regulates protein localization to ciliary membrane property_value: RO:0002161 NCBITaxon:3176 property_value: RO:0002161 NCBITaxon:3378 property_value: RO:0002161 NCBITaxon:3398 property_value: RO:0002161 NCBITaxon:4890 property_value: RO:0002161 NCBITaxon:5782 creation_date: 2014-10-24T21:32:59Z [Term] id: GO:1903569 name: positive regulation of protein localization to ciliary membrane namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of protein localization to ciliary membrane." [GO_REF:0000058, GOC:cilia, GOC:krc, GOC:TermGenie, PMID:22072986] synonym: "activation of protein localisation in ciliary membrane" NARROW [GOC:TermGenie] synonym: "activation of protein localisation to ciliary membrane" NARROW [GOC:TermGenie] synonym: "activation of protein localization in ciliary membrane" NARROW [GOC:TermGenie] synonym: "activation of protein localization to ciliary membrane" NARROW [GOC:TermGenie] synonym: "positive regulation of protein localisation in ciliary membrane" EXACT [GOC:TermGenie] synonym: "positive regulation of protein localisation to ciliary membrane" EXACT [GOC:TermGenie] synonym: "positive regulation of protein localization in ciliary membrane" EXACT [GOC:TermGenie] synonym: "up regulation of protein localisation in ciliary membrane" EXACT [GOC:TermGenie] synonym: "up regulation of protein localisation to ciliary membrane" EXACT [GOC:TermGenie] synonym: "up regulation of protein localization in ciliary membrane" EXACT [GOC:TermGenie] synonym: "up regulation of protein localization to ciliary membrane" EXACT [GOC:TermGenie] synonym: "up-regulation of protein localisation in ciliary membrane" EXACT [GOC:TermGenie] synonym: "up-regulation of protein localisation to ciliary membrane" EXACT [GOC:TermGenie] synonym: "up-regulation of protein localization in ciliary membrane" EXACT [GOC:TermGenie] synonym: "up-regulation of protein localization to ciliary membrane" EXACT [GOC:TermGenie] synonym: "upregulation of protein localisation in ciliary membrane" EXACT [GOC:TermGenie] synonym: "upregulation of protein localisation to ciliary membrane" EXACT [GOC:TermGenie] synonym: "upregulation of protein localization in ciliary membrane" EXACT [GOC:TermGenie] synonym: "upregulation of protein localization to ciliary membrane" EXACT [GOC:TermGenie] is_a: GO:1903566 ! positive regulation of protein localization to cilium is_a: GO:1903567 ! regulation of protein localization to ciliary membrane is_a: GO:1904377 ! positive regulation of protein localization to cell periphery is_a: GO:1905477 ! positive regulation of protein localization to membrane intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:1903441 ! positively regulates protein localization to ciliary membrane relationship: RO:0002213 GO:1903441 ! positively regulates protein localization to ciliary membrane property_value: RO:0002161 NCBITaxon:3176 property_value: RO:0002161 NCBITaxon:3378 property_value: RO:0002161 NCBITaxon:3398 property_value: RO:0002161 NCBITaxon:4890 property_value: RO:0002161 NCBITaxon:5782 creation_date: 2014-10-24T21:33:08Z [Term] id: GO:1903578 name: regulation of ATP metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of ATP metabolic process." [GO_REF:0000058, GOC:TermGenie, PMID:20695849] synonym: "regulation of ATP metabolism" EXACT [GOC:TermGenie] is_a: GO:1900542 ! regulation of purine nucleotide metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0046034 ! regulates ATP metabolic process relationship: RO:0002211 GO:0046034 ! regulates ATP metabolic process creation_date: 2014-10-30T19:04:24Z [Term] id: GO:1903579 name: negative regulation of ATP metabolic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of ATP metabolic process." [GO_REF:0000058, GOC:TermGenie, PMID:20695849] synonym: "down regulation of ATP metabolic process" EXACT [GOC:TermGenie] synonym: "down regulation of ATP metabolism" EXACT [GOC:TermGenie] synonym: "down-regulation of ATP metabolic process" EXACT [GOC:TermGenie] synonym: "down-regulation of ATP metabolism" EXACT [GOC:TermGenie] synonym: "downregulation of ATP metabolic process" EXACT [GOC:TermGenie] synonym: "downregulation of ATP metabolism" EXACT [GOC:TermGenie] synonym: "inhibition of ATP metabolic process" NARROW [GOC:TermGenie] synonym: "inhibition of ATP metabolism" NARROW [GOC:TermGenie] synonym: "negative regulation of ATP metabolism" EXACT [GOC:TermGenie] is_a: GO:1900543 ! negative regulation of purine nucleotide metabolic process is_a: GO:1903578 ! regulation of ATP metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0046034 ! negatively regulates ATP metabolic process relationship: RO:0002212 GO:0046034 ! negatively regulates ATP metabolic process creation_date: 2014-10-30T19:04:33Z [Term] id: GO:1903580 name: positive regulation of ATP metabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of ATP metabolic process." [GO_REF:0000058, GOC:TermGenie, PMID:20695849] synonym: "activation of ATP metabolic process" NARROW [GOC:TermGenie] synonym: "activation of ATP metabolism" NARROW [GOC:TermGenie] synonym: "positive regulation of ATP metabolism" EXACT [GOC:TermGenie] synonym: "up regulation of ATP metabolic process" EXACT [GOC:TermGenie] synonym: "up regulation of ATP metabolism" EXACT [GOC:TermGenie] synonym: "up-regulation of ATP metabolic process" EXACT [GOC:TermGenie] synonym: "up-regulation of ATP metabolism" EXACT [GOC:TermGenie] synonym: "upregulation of ATP metabolic process" EXACT [GOC:TermGenie] synonym: "upregulation of ATP metabolism" EXACT [GOC:TermGenie] is_a: GO:1900544 ! positive regulation of purine nucleotide metabolic process is_a: GO:1903578 ! regulation of ATP metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0046034 ! positively regulates ATP metabolic process relationship: RO:0002213 GO:0046034 ! positively regulates ATP metabolic process creation_date: 2014-10-30T19:04:42Z [Term] id: GO:1903581 name: regulation of basophil degranulation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of basophil degranulation." [GO_REF:0000058, GOC:TermGenie, PMID:10880837] is_a: GO:0002886 ! regulation of myeloid leukocyte mediated immunity is_a: GO:0043300 ! regulation of leukocyte degranulation is_a: GO:0050776 ! regulation of immune response intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0002561 ! regulates basophil degranulation relationship: RO:0002211 GO:0002561 ! regulates basophil degranulation creation_date: 2014-10-31T17:37:24Z [Term] id: GO:1903582 name: negative regulation of basophil degranulation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of basophil degranulation." [GO_REF:0000058, GOC:TermGenie, PMID:10880837] synonym: "down regulation of basophil degranulation" EXACT [GOC:TermGenie] synonym: "down-regulation of basophil degranulation" EXACT [GOC:TermGenie] synonym: "downregulation of basophil degranulation" EXACT [GOC:TermGenie] synonym: "inhibition of basophil degranulation" NARROW [GOC:TermGenie] is_a: GO:0002887 ! negative regulation of myeloid leukocyte mediated immunity is_a: GO:0043301 ! negative regulation of leukocyte degranulation is_a: GO:0050777 ! negative regulation of immune response is_a: GO:1903581 ! regulation of basophil degranulation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0002561 ! negatively regulates basophil degranulation relationship: RO:0002212 GO:0002561 ! negatively regulates basophil degranulation creation_date: 2014-10-31T17:37:33Z [Term] id: GO:1903583 name: positive regulation of basophil degranulation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of basophil degranulation." [GO_REF:0000058, GOC:TermGenie, PMID:10880837] synonym: "activation of basophil degranulation" NARROW [GOC:TermGenie] synonym: "up regulation of basophil degranulation" EXACT [GOC:TermGenie] synonym: "up-regulation of basophil degranulation" EXACT [GOC:TermGenie] synonym: "upregulation of basophil degranulation" EXACT [GOC:TermGenie] is_a: GO:0002888 ! positive regulation of myeloid leukocyte mediated immunity is_a: GO:0043302 ! positive regulation of leukocyte degranulation is_a: GO:0050778 ! positive regulation of immune response is_a: GO:1903581 ! regulation of basophil degranulation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0002561 ! positively regulates basophil degranulation relationship: RO:0002213 GO:0002561 ! positively regulates basophil degranulation creation_date: 2014-10-31T17:37:42Z [Term] id: GO:1903593 name: regulation of histamine secretion by mast cell namespace: biological_process def: "Any process that modulates the frequency, rate or extent of histamine secretion by mast cell." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:18253931] is_a: GO:0046883 ! regulation of hormone secretion is_a: GO:0050727 ! regulation of inflammatory response is_a: GO:0051239 ! regulation of multicellular organismal process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0002553 ! regulates histamine secretion by mast cell relationship: RO:0002211 GO:0002553 ! regulates histamine secretion by mast cell creation_date: 2014-11-06T13:19:09Z [Term] id: GO:1903594 name: negative regulation of histamine secretion by mast cell namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of histamine secretion by mast cell." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:18253931] synonym: "down regulation of histamine secretion by mast cell" EXACT [GOC:TermGenie] synonym: "down-regulation of histamine secretion by mast cell" EXACT [GOC:TermGenie] synonym: "downregulation of histamine secretion by mast cell" EXACT [GOC:TermGenie] synonym: "inhibition of histamine secretion by mast cell" NARROW [GOC:TermGenie] is_a: GO:0046888 ! negative regulation of hormone secretion is_a: GO:0050728 ! negative regulation of inflammatory response is_a: GO:1903593 ! regulation of histamine secretion by mast cell intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0002553 ! negatively regulates histamine secretion by mast cell relationship: RO:0002212 GO:0002553 ! negatively regulates histamine secretion by mast cell creation_date: 2014-11-06T13:19:18Z [Term] id: GO:1903595 name: positive regulation of histamine secretion by mast cell namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of histamine secretion by mast cell." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:18253931] synonym: "activation of histamine secretion by mast cell" NARROW [GOC:TermGenie] synonym: "up regulation of histamine secretion by mast cell" EXACT [GOC:TermGenie] synonym: "up-regulation of histamine secretion by mast cell" EXACT [GOC:TermGenie] synonym: "upregulation of histamine secretion by mast cell" EXACT [GOC:TermGenie] is_a: GO:0043306 ! positive regulation of mast cell degranulation is_a: GO:0046887 ! positive regulation of hormone secretion is_a: GO:0050729 ! positive regulation of inflammatory response is_a: GO:0051240 ! positive regulation of multicellular organismal process is_a: GO:1903593 ! regulation of histamine secretion by mast cell intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0002553 ! positively regulates histamine secretion by mast cell relationship: RO:0002213 GO:0002553 ! positively regulates histamine secretion by mast cell creation_date: 2014-11-06T13:19:26Z [Term] id: GO:1903624 name: regulation of DNA catabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of DNA catabolic process." [GO_REF:0000058, GOC:TermGenie, PMID:2001740] synonym: "regulation of DNA breakdown" EXACT [GOC:TermGenie] synonym: "regulation of DNA catabolism" EXACT [GOC:TermGenie] synonym: "regulation of DNA degradation" EXACT [GOC:TermGenie] is_a: GO:0009894 ! regulation of catabolic process is_a: GO:0051052 ! regulation of DNA metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0006308 ! regulates DNA catabolic process relationship: RO:0002211 GO:0006308 ! regulates DNA catabolic process creation_date: 2014-11-19T22:36:35Z [Term] id: GO:1903625 name: negative regulation of DNA catabolic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of DNA catabolic process." [GO_REF:0000058, GOC:TermGenie, PMID:2001740] synonym: "down regulation of DNA breakdown" EXACT [GOC:TermGenie] synonym: "down regulation of DNA catabolic process" EXACT [GOC:TermGenie] synonym: "down regulation of DNA catabolism" EXACT [GOC:TermGenie] synonym: "down regulation of DNA degradation" EXACT [GOC:TermGenie] synonym: "down-regulation of DNA breakdown" EXACT [GOC:TermGenie] synonym: "down-regulation of DNA catabolic process" EXACT [GOC:TermGenie] synonym: "down-regulation of DNA catabolism" EXACT [GOC:TermGenie] synonym: "down-regulation of DNA degradation" EXACT [GOC:TermGenie] synonym: "downregulation of DNA breakdown" EXACT [GOC:TermGenie] synonym: "downregulation of DNA catabolic process" EXACT [GOC:TermGenie] synonym: "downregulation of DNA catabolism" EXACT [GOC:TermGenie] synonym: "downregulation of DNA degradation" EXACT [GOC:TermGenie] synonym: "inhibition of DNA breakdown" NARROW [GOC:TermGenie] synonym: "inhibition of DNA catabolic process" NARROW [GOC:TermGenie] synonym: "inhibition of DNA catabolism" NARROW [GOC:TermGenie] synonym: "inhibition of DNA degradation" NARROW [GOC:TermGenie] synonym: "negative regulation of DNA breakdown" EXACT [GOC:TermGenie] synonym: "negative regulation of DNA catabolism" EXACT [GOC:TermGenie] synonym: "negative regulation of DNA degradation" EXACT [GOC:TermGenie] is_a: GO:0009895 ! negative regulation of catabolic process is_a: GO:0051053 ! negative regulation of DNA metabolic process is_a: GO:1903624 ! regulation of DNA catabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0006308 ! negatively regulates DNA catabolic process relationship: RO:0002212 GO:0006308 ! negatively regulates DNA catabolic process creation_date: 2014-11-19T22:36:43Z [Term] id: GO:1903626 name: positive regulation of DNA catabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of DNA catabolic process." [GO_REF:0000058, GOC:TermGenie, PMID:2001740] synonym: "activation of DNA breakdown" NARROW [GOC:TermGenie] synonym: "activation of DNA catabolic process" NARROW [GOC:TermGenie] synonym: "activation of DNA catabolism" NARROW [GOC:TermGenie] synonym: "activation of DNA degradation" NARROW [GOC:TermGenie] synonym: "positive regulation of DNA breakdown" EXACT [GOC:TermGenie] synonym: "positive regulation of DNA catabolism" EXACT [GOC:TermGenie] synonym: "positive regulation of DNA degradation" EXACT [GOC:TermGenie] synonym: "up regulation of DNA breakdown" EXACT [GOC:TermGenie] synonym: "up regulation of DNA catabolic process" EXACT [GOC:TermGenie] synonym: "up regulation of DNA catabolism" EXACT [GOC:TermGenie] synonym: "up regulation of DNA degradation" EXACT [GOC:TermGenie] synonym: "up-regulation of DNA breakdown" EXACT [GOC:TermGenie] synonym: "up-regulation of DNA catabolic process" EXACT [GOC:TermGenie] synonym: "up-regulation of DNA catabolism" EXACT [GOC:TermGenie] synonym: "up-regulation of DNA degradation" EXACT [GOC:TermGenie] synonym: "upregulation of DNA breakdown" EXACT [GOC:TermGenie] synonym: "upregulation of DNA catabolic process" EXACT [GOC:TermGenie] synonym: "upregulation of DNA catabolism" EXACT [GOC:TermGenie] synonym: "upregulation of DNA degradation" EXACT [GOC:TermGenie] is_a: GO:0009896 ! positive regulation of catabolic process is_a: GO:0051054 ! positive regulation of DNA metabolic process is_a: GO:1903624 ! regulation of DNA catabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0006308 ! positively regulates DNA catabolic process relationship: RO:0002213 GO:0006308 ! positively regulates DNA catabolic process creation_date: 2014-11-19T22:36:51Z [Term] id: GO:1903680 name: acinar cell of sebaceous gland differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires the specialized features of an acinar cell of sebaceous gland." [GO_REF:0000086, GOC:TermGenie, PMID:17018284, PMID:18334552, PMID:19944183] synonym: "sebocyte differentiation" EXACT [CL:0002140] is_a: GO:0001949 ! sebaceous gland cell differentiation is_a: GO:0090425 ! acinar cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0002140 ! results in acquisition of features of skin sebocyte relationship: RO:0002315 CL:0002140 ! results in acquisition of features of skin sebocyte creation_date: 2014-11-30T11:51:57Z [Term] id: GO:1903684 name: regulation of border follicle cell migration namespace: biological_process def: "Any process that modulates the frequency, rate or extent of border follicle cell migration." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:18394891] synonym: "regulation of border cell migration" BROAD [GOC:TermGenie] is_a: GO:0010632 ! regulation of epithelial cell migration intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0007298 ! regulates border follicle cell migration relationship: RO:0002211 GO:0007298 ! regulates border follicle cell migration creation_date: 2014-12-01T13:35:39Z [Term] id: GO:1903687 name: negative regulation of border follicle cell migration namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of border follicle cell migration." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:18394891] synonym: "inhibition of border follicle cell migration" NARROW [GOC:TermGenie] is_a: GO:0010633 ! negative regulation of epithelial cell migration is_a: GO:1903684 ! regulation of border follicle cell migration intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0007298 ! negatively regulates border follicle cell migration relationship: RO:0002212 GO:0007298 ! negatively regulates border follicle cell migration creation_date: 2014-12-01T13:41:05Z [Term] id: GO:1903688 name: positive regulation of border follicle cell migration namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of border follicle cell migration." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:18394891] synonym: "activation of border follicle cell migration" NARROW [GOC:TermGenie] is_a: GO:0010634 ! positive regulation of epithelial cell migration is_a: GO:1903684 ! regulation of border follicle cell migration intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0007298 ! positively regulates border follicle cell migration relationship: RO:0002213 GO:0007298 ! positively regulates border follicle cell migration creation_date: 2014-12-01T13:41:19Z [Term] id: GO:1903697 name: negative regulation of microvillus assembly namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of microvillus assembly." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:22797597] synonym: "down regulation of microvillus assembly" EXACT [GOC:TermGenie] synonym: "down regulation of microvillus biogenesis" RELATED [GOC:TermGenie] synonym: "down-regulation of microvillus assembly" EXACT [GOC:TermGenie] synonym: "down-regulation of microvillus biogenesis" RELATED [GOC:TermGenie] synonym: "downregulation of microvillus assembly" EXACT [GOC:TermGenie] synonym: "downregulation of microvillus biogenesis" RELATED [GOC:TermGenie] synonym: "inhibition of microvillus assembly" NARROW [GOC:TermGenie] synonym: "inhibition of microvillus biogenesis" RELATED [GOC:TermGenie] synonym: "negative regulation of microvillus biogenesis" RELATED [GOC:TermGenie] is_a: GO:0032534 ! regulation of microvillus assembly is_a: GO:0120033 ! negative regulation of plasma membrane bounded cell projection assembly intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0030033 ! negatively regulates microvillus assembly relationship: RO:0002212 GO:0030033 ! negatively regulates microvillus assembly creation_date: 2014-12-03T11:45:08Z [Term] id: GO:1903698 name: positive regulation of microvillus assembly namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of microvillus assembly." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:22797597] synonym: "activation of microvillus assembly" NARROW [GOC:TermGenie] synonym: "activation of microvillus biogenesis" RELATED [GOC:TermGenie] synonym: "positive regulation of microvillus biogenesis" RELATED [GOC:TermGenie] synonym: "up regulation of microvillus assembly" EXACT [GOC:TermGenie] synonym: "up regulation of microvillus biogenesis" RELATED [GOC:TermGenie] synonym: "up-regulation of microvillus assembly" EXACT [GOC:TermGenie] synonym: "up-regulation of microvillus biogenesis" RELATED [GOC:TermGenie] synonym: "upregulation of microvillus assembly" EXACT [GOC:TermGenie] synonym: "upregulation of microvillus biogenesis" RELATED [GOC:TermGenie] is_a: GO:0032534 ! regulation of microvillus assembly is_a: GO:0120034 ! positive regulation of plasma membrane bounded cell projection assembly intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0030033 ! positively regulates microvillus assembly relationship: RO:0002213 GO:0030033 ! positively regulates microvillus assembly creation_date: 2014-12-03T11:45:17Z [Term] id: GO:1903700 name: caecum development namespace: biological_process def: "The process whose specific outcome is the progression of a caecum over time, from its formation to the mature structure." [GO_REF:0000094, GOC:TermGenie, ISBN:0-683-40008-8] synonym: "blind intestine development" RELATED [GOC:TermGenie] synonym: "blindgut development" RELATED [GOC:TermGenie] synonym: "caeca development" NARROW [GOC:TermGenie] synonym: "ceca development" NARROW [GOC:TermGenie] synonym: "cecum development" EXACT [GOC:TermGenie] synonym: "intestinum caecum development" RELATED [GOC:TermGenie] synonym: "intestinum crassum caecum development" EXACT [GOC:TermGenie] synonym: "intestinum crassum cecum development" RELATED [GOC:TermGenie] is_a: GO:0048856 ! anatomical structure development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0001153 ! results in development of caecum relationship: RO:0002296 UBERON:0001153 ! results in development of caecum creation_date: 2014-12-03T12:05:00Z [Term] id: GO:1903701 name: substantia propria of cornea development namespace: biological_process def: "The process whose specific outcome is the progression of a substantia propria of cornea over time, from its formation to the mature structure." [GO_REF:0000094, GOC:TermGenie, PMID:12556382] synonym: "corneal stroma development" EXACT [GOC:TermGenie] synonym: "stroma of cornea development" EXACT [GOC:TermGenie] synonym: "substantia propria development" RELATED [GOC:TermGenie] is_a: GO:0048856 ! anatomical structure development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0001777 ! results in development of substantia propria of cornea relationship: RO:0002296 UBERON:0001777 ! results in development of substantia propria of cornea creation_date: 2014-12-03T13:12:09Z [Term] id: GO:1903702 name: esophagus development namespace: biological_process def: "The process whose specific outcome is the progression of an esophagus over time, from its formation to the mature structure." [GO_REF:0000094, GOC:TermGenie, ISBN:0-683-40008-8] synonym: "esophageal development" EXACT [MGI:csmith] synonym: "gullet development" EXACT [GOC:TermGenie] synonym: "oesophagus development" EXACT [GOC:TermGenie] is_a: GO:0048856 ! anatomical structure development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0001043 ! results in development of esophagus relationship: RO:0002296 UBERON:0001043 ! results in development of esophagus creation_date: 2014-12-03T14:41:30Z [Term] id: GO:1903703 name: enterocyte differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires the specialized features of an enterocyte." [GO_REF:0000086, GOC:TermGenie, PMID:16782882, Wikipedia:List_of_intestinal_epithelial_differentiation_genes] is_a: GO:0060575 ! intestinal epithelial cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000584 ! results in acquisition of features of enterocyte relationship: RO:0002315 CL:0000584 ! results in acquisition of features of enterocyte creation_date: 2014-12-03T15:08:51Z [Term] id: GO:1903706 name: regulation of hemopoiesis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of hemopoiesis." [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:20080761] comment: An example of this is Atg7 in mouse (UniProt symbol, Q9D906) in PMID:20080761, inferred from mutant phenotype. synonym: "regulation of blood cell biosynthesis" EXACT [GOC:TermGenie] synonym: "regulation of blood cell formation" EXACT [GOC:TermGenie] synonym: "regulation of haemopoiesis" EXACT [GOC:TermGenie] synonym: "regulation of hematopoiesis" EXACT [GOC:TermGenie] is_a: GO:0002682 ! regulation of immune system process is_a: GO:0060284 ! regulation of cell development is_a: GO:2000026 ! regulation of multicellular organismal development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0030097 ! regulates hemopoiesis relationship: RO:0002211 GO:0030097 ! regulates hemopoiesis creation_date: 2014-12-04T15:34:13Z [Term] id: GO:1903707 name: negative regulation of hemopoiesis namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of hemopoiesis." [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:20080761] comment: An example of this is Atg7 in mouse (UniProt symbol, Q9D906) in PMID:20080761, inferred from mutant phenotype. synonym: "down regulation of blood cell biosynthesis" EXACT [GOC:TermGenie] synonym: "down regulation of blood cell formation" EXACT [GOC:TermGenie] synonym: "down regulation of haemopoiesis" EXACT [GOC:TermGenie] synonym: "down regulation of hematopoiesis" EXACT [GOC:TermGenie] synonym: "down regulation of hemopoiesis" EXACT [GOC:TermGenie] synonym: "down-regulation of blood cell biosynthesis" EXACT [GOC:TermGenie] synonym: "down-regulation of blood cell formation" EXACT [GOC:TermGenie] synonym: "down-regulation of haemopoiesis" EXACT [GOC:TermGenie] synonym: "down-regulation of hematopoiesis" EXACT [GOC:TermGenie] synonym: "down-regulation of hemopoiesis" EXACT [GOC:TermGenie] synonym: "downregulation of blood cell biosynthesis" EXACT [GOC:TermGenie] synonym: "downregulation of blood cell formation" EXACT [GOC:TermGenie] synonym: "downregulation of haemopoiesis" EXACT [GOC:TermGenie] synonym: "downregulation of hematopoiesis" EXACT [GOC:TermGenie] synonym: "downregulation of hemopoiesis" EXACT [GOC:TermGenie] synonym: "inhibition of blood cell biosynthesis" NARROW [GOC:TermGenie] synonym: "inhibition of blood cell formation" NARROW [GOC:TermGenie] synonym: "inhibition of haemopoiesis" NARROW [GOC:TermGenie] synonym: "inhibition of hematopoiesis" NARROW [GOC:TermGenie] synonym: "inhibition of hemopoiesis" NARROW [GOC:TermGenie] synonym: "negative regulation of blood cell biosynthesis" EXACT [GOC:TermGenie] synonym: "negative regulation of blood cell formation" EXACT [GOC:TermGenie] synonym: "negative regulation of haemopoiesis" EXACT [GOC:TermGenie] synonym: "negative regulation of hematopoiesis" EXACT [GOC:TermGenie] is_a: GO:0002683 ! negative regulation of immune system process is_a: GO:0010721 ! negative regulation of cell development is_a: GO:0051241 ! negative regulation of multicellular organismal process is_a: GO:1903706 ! regulation of hemopoiesis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0030097 ! negatively regulates hemopoiesis relationship: RO:0002212 GO:0030097 ! negatively regulates hemopoiesis creation_date: 2014-12-04T15:34:21Z [Term] id: GO:1903708 name: positive regulation of hemopoiesis namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of hemopoiesis." [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:20080761] comment: An example of this is Atg7 in mouse (UniProt symbol, Q9D906) in PMID:20080761, inferred from mutant phenotype. synonym: "activation of blood cell biosynthesis" NARROW [GOC:TermGenie] synonym: "activation of blood cell formation" NARROW [GOC:TermGenie] synonym: "activation of haemopoiesis" NARROW [GOC:TermGenie] synonym: "activation of hematopoiesis" NARROW [GOC:TermGenie] synonym: "activation of hemopoiesis" NARROW [GOC:TermGenie] synonym: "positive regulation of blood cell biosynthesis" EXACT [GOC:TermGenie] synonym: "positive regulation of blood cell formation" EXACT [GOC:TermGenie] synonym: "positive regulation of haemopoiesis" EXACT [GOC:TermGenie] synonym: "positive regulation of hematopoiesis" EXACT [GOC:TermGenie] synonym: "up regulation of blood cell biosynthesis" EXACT [GOC:TermGenie] synonym: "up regulation of blood cell formation" EXACT [GOC:TermGenie] synonym: "up regulation of haemopoiesis" EXACT [GOC:TermGenie] synonym: "up regulation of hematopoiesis" EXACT [GOC:TermGenie] synonym: "up regulation of hemopoiesis" EXACT [GOC:TermGenie] synonym: "up-regulation of blood cell biosynthesis" EXACT [GOC:TermGenie] synonym: "up-regulation of blood cell formation" EXACT [GOC:TermGenie] synonym: "up-regulation of haemopoiesis" EXACT [GOC:TermGenie] synonym: "up-regulation of hematopoiesis" EXACT [GOC:TermGenie] synonym: "up-regulation of hemopoiesis" EXACT [GOC:TermGenie] synonym: "upregulation of blood cell biosynthesis" EXACT [GOC:TermGenie] synonym: "upregulation of blood cell formation" EXACT [GOC:TermGenie] synonym: "upregulation of haemopoiesis" EXACT [GOC:TermGenie] synonym: "upregulation of hematopoiesis" EXACT [GOC:TermGenie] synonym: "upregulation of hemopoiesis" EXACT [GOC:TermGenie] is_a: GO:0002684 ! positive regulation of immune system process is_a: GO:0010720 ! positive regulation of cell development is_a: GO:0051240 ! positive regulation of multicellular organismal process is_a: GO:1903706 ! regulation of hemopoiesis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0030097 ! positively regulates hemopoiesis relationship: RO:0002213 GO:0030097 ! positively regulates hemopoiesis creation_date: 2014-12-04T15:34:30Z [Term] id: GO:1903709 name: uterine gland development namespace: biological_process def: "The process whose specific outcome is the progression of an uterine gland over time, from its formation to the mature structure." [GO_REF:0000094, GOC:TermGenie, PMID:23619340] synonym: "endometrial gland development" EXACT [GOC:TermGenie] synonym: "endometrium gland development" EXACT [GOC:TermGenie] synonym: "glandulae uterinae development" RELATED [GOC:TermGenie] synonym: "glandular part of endometrium development" RELATED [GOC:TermGenie] synonym: "set of uterine glands development" RELATED [GOC:TermGenie] synonym: "uterine glands development" EXACT [GOC:TermGenie] synonym: "uterine glands set development" EXACT [GOC:TermGenie] is_a: GO:0048732 ! gland development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0002451 ! results in development of endometrial gland relationship: RO:0002162 NCBITaxon:32525 ! in taxon Theria relationship: RO:0002296 UBERON:0002451 ! results in development of endometrial gland creation_date: 2014-12-04T18:57:21Z [Term] id: GO:1903728 name: luteal cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires the specialized features of a luteal cell. Large luteal cells develop from granulosa cells. Small luteal cells develop from theca cells." [GO_REF:0000086, GOC:TermGenie, MP:0001133] synonym: "lutein cell differentiation" EXACT [CL:0000175] is_a: GO:0030154 ! cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000175 ! results in acquisition of features of luteal cell relationship: RO:0002315 CL:0000175 ! results in acquisition of features of luteal cell creation_date: 2014-12-10T01:36:43Z [Term] id: GO:1903729 name: regulation of plasma membrane organization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of plasma membrane organization." [GO_REF:0000058, GOC:TermGenie, PMID:24514900] synonym: "regulation of plasma membrane organisation" EXACT [GOC:TermGenie] synonym: "regulation of plasma membrane organization and biogenesis" RELATED [GOC:TermGenie] is_a: GO:0051128 ! regulation of cellular component organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0007009 ! regulates plasma membrane organization relationship: RO:0002211 GO:0007009 ! regulates plasma membrane organization creation_date: 2014-12-10T18:59:44Z [Term] id: GO:1903747 name: regulation of establishment of protein localization to mitochondrion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of establishment of protein localization to mitochondrion." [GO_REF:0000058, GOC:TermGenie, PMID:16857185] synonym: "regulation of establishment of protein localisation to mitochondrion" EXACT [GOC:TermGenie] synonym: "regulation of establishment of protein localization in mitochondrion" EXACT [GOC:TermGenie] is_a: GO:0070201 ! regulation of establishment of protein localization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0072655 ! regulates establishment of protein localization to mitochondrion relationship: RO:0002211 GO:0072655 ! regulates establishment of protein localization to mitochondrion creation_date: 2014-12-12T22:18:09Z [Term] id: GO:1903748 name: negative regulation of establishment of protein localization to mitochondrion namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of establishment of protein localization to mitochondrion." [GO_REF:0000058, GOC:TermGenie, PMID:16857185] synonym: "down regulation of establishment of protein localisation to mitochondrion" EXACT [GOC:TermGenie] synonym: "down regulation of establishment of protein localization in mitochondrion" EXACT [GOC:TermGenie] synonym: "down regulation of establishment of protein localization to mitochondrion" EXACT [GOC:TermGenie] synonym: "down-regulation of establishment of protein localisation to mitochondrion" EXACT [GOC:TermGenie] synonym: "down-regulation of establishment of protein localization in mitochondrion" EXACT [GOC:TermGenie] synonym: "down-regulation of establishment of protein localization to mitochondrion" EXACT [GOC:TermGenie] synonym: "downregulation of establishment of protein localisation to mitochondrion" EXACT [GOC:TermGenie] synonym: "downregulation of establishment of protein localization in mitochondrion" EXACT [GOC:TermGenie] synonym: "downregulation of establishment of protein localization to mitochondrion" EXACT [GOC:TermGenie] synonym: "inhibition of establishment of protein localisation to mitochondrion" NARROW [GOC:TermGenie] synonym: "inhibition of establishment of protein localization in mitochondrion" NARROW [GOC:TermGenie] synonym: "inhibition of establishment of protein localization to mitochondrion" NARROW [GOC:TermGenie] synonym: "negative regulation of establishment of protein localisation to mitochondrion" EXACT [GOC:TermGenie] synonym: "negative regulation of establishment of protein localization in mitochondrion" EXACT [GOC:TermGenie] is_a: GO:1903747 ! regulation of establishment of protein localization to mitochondrion is_a: GO:1904950 ! negative regulation of establishment of protein localization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0072655 ! negatively regulates establishment of protein localization to mitochondrion relationship: RO:0002212 GO:0072655 ! negatively regulates establishment of protein localization to mitochondrion creation_date: 2014-12-12T22:18:18Z [Term] id: GO:1903749 name: positive regulation of establishment of protein localization to mitochondrion namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of establishment of protein localization to mitochondrion." [GO_REF:0000058, GOC:TermGenie, PMID:16857185] synonym: "activation of establishment of protein localisation to mitochondrion" NARROW [GOC:TermGenie] synonym: "activation of establishment of protein localization in mitochondrion" NARROW [GOC:TermGenie] synonym: "activation of establishment of protein localization to mitochondrion" NARROW [GOC:TermGenie] synonym: "positive regulation of establishment of protein localisation to mitochondrion" EXACT [GOC:TermGenie] synonym: "positive regulation of establishment of protein localization in mitochondrion" EXACT [GOC:TermGenie] synonym: "up regulation of establishment of protein localisation to mitochondrion" EXACT [GOC:TermGenie] synonym: "up regulation of establishment of protein localization in mitochondrion" EXACT [GOC:TermGenie] synonym: "up regulation of establishment of protein localization to mitochondrion" EXACT [GOC:TermGenie] synonym: "up-regulation of establishment of protein localisation to mitochondrion" EXACT [GOC:TermGenie] synonym: "up-regulation of establishment of protein localization in mitochondrion" EXACT [GOC:TermGenie] synonym: "up-regulation of establishment of protein localization to mitochondrion" EXACT [GOC:TermGenie] synonym: "upregulation of establishment of protein localisation to mitochondrion" EXACT [GOC:TermGenie] synonym: "upregulation of establishment of protein localization in mitochondrion" EXACT [GOC:TermGenie] synonym: "upregulation of establishment of protein localization to mitochondrion" EXACT [GOC:TermGenie] xref: Reactome:R-HSA-114452 "Activation of BH3-only proteins" xref: Reactome:R-HSA-75108 "Activation, myristolyation of BID and translocation to mitochondria" is_a: GO:1903747 ! regulation of establishment of protein localization to mitochondrion is_a: GO:1904951 ! positive regulation of establishment of protein localization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0072655 ! positively regulates establishment of protein localization to mitochondrion relationship: RO:0002213 GO:0072655 ! positively regulates establishment of protein localization to mitochondrion creation_date: 2014-12-12T22:18:26Z [Term] id: GO:1903764 name: regulation of potassium ion export across plasma membrane namespace: biological_process def: "Any process that modulates the frequency, rate or extent of potassium ion export across the plasma membrane." [GO_REF:0000058, GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:rl, GOC:TermGenie, PMID:19646991] synonym: "regulation of potassium export" BROAD [GOC:TermGenie] synonym: "regulation of potassium export across plasma membrane" BROAD [GOC:TermGenie] synonym: "regulation of potassium ion export" BROAD [] is_a: GO:1901379 ! regulation of potassium ion transmembrane transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0097623 ! regulates potassium ion export across plasma membrane relationship: RO:0002211 GO:0097623 ! regulates potassium ion export across plasma membrane creation_date: 2013-07-17T16:39:53Z [Term] id: GO:1903765 name: negative regulation of potassium ion export across plasma membrane namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of potassium ion export across the plasma membrane." [GO_REF:0000058, GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:rl, GOC:TermGenie, PMID:19646991] synonym: "down regulation of potassium export" BROAD [GOC:TermGenie] synonym: "down regulation of potassium ion export" BROAD [GOC:TermGenie] synonym: "down regulation of potassium ion export across plasma membrane" EXACT [GOC:TermGenie] synonym: "down-regulation of potassium export" BROAD [GOC:TermGenie] synonym: "down-regulation of potassium ion export" BROAD [GOC:TermGenie] synonym: "down-regulation of potassium ion export across plasma membrane" EXACT [GOC:TermGenie] synonym: "downregulation of potassium export" BROAD [GOC:TermGenie] synonym: "downregulation of potassium ion export" BROAD [GOC:TermGenie] synonym: "downregulation of potassium ion export across plasma membrane" EXACT [GOC:TermGenie] synonym: "inhibition of potassium export" NARROW [GOC:TermGenie] synonym: "inhibition of potassium ion export" RELATED [GOC:TermGenie] synonym: "inhibition of potassium ion export across plasma membrane" EXACT [GOC:TermGenie] synonym: "negative regulation of potassium export" BROAD [GOC:TermGenie] synonym: "negative regulation of potassium ion export" BROAD [] is_a: GO:1901380 ! negative regulation of potassium ion transmembrane transport is_a: GO:1903764 ! regulation of potassium ion export across plasma membrane intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0097623 ! negatively regulates potassium ion export across plasma membrane relationship: RO:0002212 GO:0097623 ! negatively regulates potassium ion export across plasma membrane creation_date: 2013-07-17T16:40:02Z [Term] id: GO:1903766 name: positive regulation of potassium ion export across plasma membrane namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of potassium ion export across the plasma membrane." [GO_REF:0000058, GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:rl, GOC:TermGenie, PMID:19646991] synonym: "activation of potassium export" RELATED [GOC:TermGenie] synonym: "activation of potassium ion export" RELATED [GOC:TermGenie] synonym: "activation of potassium ion export across plasma membrane" RELATED [GOC:TermGenie] synonym: "positive regulation of potassium export" BROAD [GOC:TermGenie] synonym: "positive regulation of potassium ion export" BROAD [] synonym: "up regulation of potassium export" BROAD [GOC:TermGenie] synonym: "up regulation of potassium ion export" BROAD [GOC:TermGenie] synonym: "up regulation of potassium ion export across plasma membrane" EXACT [GOC:TermGenie] synonym: "up-regulation of potassium export" BROAD [GOC:TermGenie] synonym: "up-regulation of potassium ion export" BROAD [GOC:TermGenie] synonym: "up-regulation of potassium ion export across plasma membrane" EXACT [GOC:TermGenie] synonym: "upregulation of potassium export" BROAD [GOC:TermGenie] synonym: "upregulation of potassium ion export" BROAD [GOC:TermGenie] synonym: "upregulation of potassium ion export across plasma membrane" EXACT [GOC:TermGenie] is_a: GO:1901381 ! positive regulation of potassium ion transmembrane transport is_a: GO:1903764 ! regulation of potassium ion export across plasma membrane intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0097623 ! positively regulates potassium ion export across plasma membrane relationship: RO:0002213 GO:0097623 ! positively regulates potassium ion export across plasma membrane creation_date: 2013-07-17T16:40:10Z [Term] id: GO:1903778 name: protein localization to vacuolar membrane namespace: biological_process def: "A process in which a protein is transported to, or maintained in, a location within a vacuolar membrane." [GO_REF:0000087, GOC:TermGenie, PMID:25378562] synonym: "protein localisation in vacuolar membrane" EXACT [GOC:TermGenie] synonym: "protein localisation to vacuolar membrane" EXACT [GOC:TermGenie] synonym: "protein localization in vacuolar membrane" EXACT [GOC:TermGenie] is_a: GO:0072657 ! protein localization to membrane is_a: GO:0072665 ! protein localization to vacuole intersection_of: GO:0008104 ! intracellular protein localization intersection_of: RO:0002339 GO:0005774 ! has target end location vacuolar membrane relationship: RO:0002339 GO:0005774 ! has target end location vacuolar membrane creation_date: 2015-01-07T13:15:54Z [Term] id: GO:1903779 name: regulation of cardiac conduction namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cardiac conduction." [GO_REF:0000058, GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:rph, GOC:TermGenie, PMID:12967627] xref: Reactome:R-HSA-5578768 "Physiological factors" xref: Reactome:R-HSA-5578775 "Ion homeostasis" is_a: GO:0008016 ! regulation of heart contraction intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0061337 ! regulates cardiac conduction relationship: RO:0002211 GO:0061337 ! regulates cardiac conduction property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 creation_date: 2015-01-07T13:20:11Z [Term] id: GO:1903780 name: negative regulation of cardiac conduction namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of cardiac conduction." [GO_REF:0000058, GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:rph, GOC:TermGenie, PMID:12967627] synonym: "down regulation of cardiac conduction" EXACT [GOC:TermGenie] synonym: "down-regulation of cardiac conduction" EXACT [GOC:TermGenie] synonym: "downregulation of cardiac conduction" EXACT [GOC:TermGenie] synonym: "inhibition of cardiac conduction" NARROW [GOC:TermGenie] is_a: GO:0048519 ! negative regulation of biological process is_a: GO:1903779 ! regulation of cardiac conduction intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0061337 ! negatively regulates cardiac conduction relationship: RO:0002212 GO:0061337 ! negatively regulates cardiac conduction property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 creation_date: 2015-01-07T13:20:20Z [Term] id: GO:1903781 name: positive regulation of cardiac conduction namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cardiac conduction." [GO_REF:0000058, GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:rph, GOC:TermGenie, PMID:12967627] synonym: "activation of cardiac conduction" NARROW [GOC:TermGenie] synonym: "up regulation of cardiac conduction" EXACT [GOC:TermGenie] synonym: "up-regulation of cardiac conduction" EXACT [GOC:TermGenie] synonym: "upregulation of cardiac conduction" EXACT [GOC:TermGenie] is_a: GO:0048518 ! positive regulation of biological process is_a: GO:1903779 ! regulation of cardiac conduction intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0061337 ! positively regulates cardiac conduction relationship: RO:0002213 GO:0061337 ! positively regulates cardiac conduction property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 creation_date: 2015-01-07T13:20:28Z [Term] id: GO:1903782 name: regulation of sodium ion import across plasma membrane namespace: biological_process def: "Any process that modulates the frequency, rate or extent of sodium ion import across the plasma membrane." [GO_REF:0000058, GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:nc, GOC:TermGenie, PMID:19376779] is_a: GO:1902305 ! regulation of sodium ion transmembrane transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0098719 ! regulates sodium ion import across plasma membrane relationship: RO:0002211 GO:0098719 ! regulates sodium ion import across plasma membrane creation_date: 2015-01-07T16:48:43Z [Term] id: GO:1903783 name: negative regulation of sodium ion import across plasma membrane namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of sodium ion import across the plasma membrane." [GO_REF:0000058, GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:nc, GOC:TermGenie, PMID:19376779] synonym: "down regulation of sodium ion import across plasma membrane" EXACT [GOC:TermGenie] synonym: "down-regulation of sodium ion import across plasma membrane" EXACT [GOC:TermGenie] synonym: "downregulation of sodium ion import across plasma membrane" EXACT [GOC:TermGenie] synonym: "inhibition of sodium ion import across plasma membrane" NARROW [GOC:TermGenie] is_a: GO:1902306 ! negative regulation of sodium ion transmembrane transport is_a: GO:1903782 ! regulation of sodium ion import across plasma membrane intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0098719 ! negatively regulates sodium ion import across plasma membrane relationship: RO:0002212 GO:0098719 ! negatively regulates sodium ion import across plasma membrane creation_date: 2015-01-07T16:48:51Z [Term] id: GO:1903784 name: positive regulation of sodium ion import across plasma membrane namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of sodium ion import across the plasma membrane." [GO_REF:0000058, GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:nc, GOC:TermGenie, PMID:19376779] synonym: "activation of sodium ion import across plasma membrane" NARROW [GOC:TermGenie] synonym: "up regulation of sodium ion import across plasma membrane" EXACT [GOC:TermGenie] synonym: "up-regulation of sodium ion import across plasma membrane" EXACT [GOC:TermGenie] synonym: "upregulation of sodium ion import across plasma membrane" EXACT [GOC:TermGenie] is_a: GO:1902307 ! positive regulation of sodium ion transmembrane transport is_a: GO:1903782 ! regulation of sodium ion import across plasma membrane intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0098719 ! positively regulates sodium ion import across plasma membrane relationship: RO:0002213 GO:0098719 ! positively regulates sodium ion import across plasma membrane creation_date: 2015-01-07T16:49:00Z [Term] id: GO:1903789 name: regulation of amino acid transmembrane transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of amino acid transmembrane transport." [GO_REF:0000058, GOC:TermGenie, PMID:16115814] synonym: "regulation of amino acid membrane transport" EXACT [GOC:TermGenie] is_a: GO:0034762 ! regulation of transmembrane transport is_a: GO:0051955 ! regulation of amino acid transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0003333 ! regulates amino acid transmembrane transport relationship: RO:0002211 GO:0003333 ! regulates amino acid transmembrane transport creation_date: 2015-01-08T17:42:18Z [Term] id: GO:1903804 name: glycine import across plasma membrane namespace: biological_process def: "The directed movement of glycine from outside of a cell, across the plasma membrane and into the cytosol." [GO_REF:0000075, GOC:TermGenie, PMID:23895341] synonym: "glycine import" BROAD [] synonym: "glycine import into cell" EXACT [] is_a: GO:0015816 ! glycine transport is_a: GO:0089718 ! amino acid import across plasma membrane is_a: GO:1905039 ! carboxylic acid transmembrane transport intersection_of: GO:0006810 ! transport intersection_of: RO:0002338 GO:0005576 ! has target start location extracellular region intersection_of: RO:0002339 GO:0005829 ! has target end location cytosol intersection_of: RO:0002342 GO:0005886 ! results in transport across plasma membrane intersection_of: RO:0004009 CHEBI:57305 ! has primary input creation_date: 2012-05-11T01:16:45Z [Term] id: GO:1903810 name: L-histidine import across plasma membrane namespace: biological_process def: "The directed movement of L-histidine from outside of a cell, across the plasma membrane and into the cytosol." [GO_REF:0000075, GOC:TermGenie, PMID:23895341] synonym: "histidine import" BROAD [] synonym: "L-histidine import" BROAD [] synonym: "L-histidine import into cell" EXACT [] is_a: GO:0089709 ! L-histidine transmembrane transport is_a: GO:0089718 ! amino acid import across plasma membrane intersection_of: GO:0006810 ! transport intersection_of: RO:0002338 GO:0005576 ! has target start location extracellular region intersection_of: RO:0002339 GO:0005829 ! has target end location cytosol intersection_of: RO:0002342 GO:0005886 ! results in transport across plasma membrane intersection_of: RO:0004009 CHEBI:57595 ! has primary input creation_date: 2012-10-05T10:20:50Z [Term] id: GO:1903817 name: negative regulation of voltage-gated potassium channel activity namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of voltage-gated potassium channel activity." [GO_REF:0000059, GOC:TermGenie, PMID:19219384] subset: gocheck_obsoletion_candidate synonym: "down regulation of voltage gated potassium channel activity" EXACT [GOC:TermGenie] synonym: "down regulation of voltage-dependent potassium channel activity" EXACT [GOC:TermGenie] synonym: "down regulation of voltage-gated potassium channel activity" EXACT [GOC:TermGenie] synonym: "down regulation of voltage-gated potassium ion channel activity" EXACT [GOC:TermGenie] synonym: "down regulation of voltage-sensitive potassium channel" EXACT [GOC:TermGenie] synonym: "down-regulation of voltage gated potassium channel activity" EXACT [GOC:TermGenie] synonym: "down-regulation of voltage-dependent potassium channel activity" EXACT [GOC:TermGenie] synonym: "down-regulation of voltage-gated potassium channel activity" EXACT [GOC:TermGenie] synonym: "down-regulation of voltage-gated potassium ion channel activity" EXACT [GOC:TermGenie] synonym: "down-regulation of voltage-sensitive potassium channel" EXACT [GOC:TermGenie] synonym: "downregulation of voltage gated potassium channel activity" EXACT [GOC:TermGenie] synonym: "downregulation of voltage-dependent potassium channel activity" EXACT [GOC:TermGenie] synonym: "downregulation of voltage-gated potassium channel activity" EXACT [GOC:TermGenie] synonym: "downregulation of voltage-gated potassium ion channel activity" EXACT [GOC:TermGenie] synonym: "downregulation of voltage-sensitive potassium channel" EXACT [GOC:TermGenie] synonym: "inhibition of voltage gated potassium channel activity" NARROW [GOC:TermGenie] synonym: "inhibition of voltage-dependent potassium channel activity" NARROW [GOC:TermGenie] synonym: "inhibition of voltage-gated potassium channel activity" NARROW [GOC:TermGenie] synonym: "inhibition of voltage-gated potassium ion channel activity" NARROW [GOC:TermGenie] synonym: "inhibition of voltage-sensitive potassium channel" NARROW [GOC:TermGenie] synonym: "negative regulation of voltage gated potassium channel activity" EXACT [GOC:TermGenie] synonym: "negative regulation of voltage-dependent potassium channel activity" EXACT [GOC:TermGenie] synonym: "negative regulation of voltage-gated potassium ion channel activity" EXACT [GOC:TermGenie] synonym: "negative regulation of voltage-sensitive potassium channel" EXACT [GOC:TermGenie] is_a: GO:1901017 ! negative regulation of potassium ion transmembrane transporter activity intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0005249 ! negatively regulates voltage-gated potassium channel activity relationship: RO:0002212 GO:0005249 ! negatively regulates voltage-gated potassium channel activity creation_date: 2015-01-16T17:22:08Z [Term] id: GO:1903818 name: positive regulation of voltage-gated potassium channel activity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of voltage-gated potassium channel activity." [GO_REF:0000059, GOC:TermGenie, PMID:19219384] subset: gocheck_obsoletion_candidate synonym: "activation of voltage gated potassium channel activity" NARROW [GOC:TermGenie] synonym: "activation of voltage-dependent potassium channel activity" NARROW [GOC:TermGenie] synonym: "activation of voltage-gated potassium channel activity" NARROW [GOC:TermGenie] synonym: "activation of voltage-gated potassium ion channel activity" NARROW [GOC:TermGenie] synonym: "activation of voltage-sensitive potassium channel" NARROW [GOC:TermGenie] synonym: "positive regulation of voltage gated potassium channel activity" EXACT [GOC:TermGenie] synonym: "positive regulation of voltage-dependent potassium channel activity" EXACT [GOC:TermGenie] synonym: "positive regulation of voltage-gated potassium ion channel activity" EXACT [GOC:TermGenie] synonym: "positive regulation of voltage-sensitive potassium channel" EXACT [GOC:TermGenie] synonym: "up regulation of voltage gated potassium channel activity" EXACT [GOC:TermGenie] synonym: "up regulation of voltage-dependent potassium channel activity" EXACT [GOC:TermGenie] synonym: "up regulation of voltage-gated potassium channel activity" EXACT [GOC:TermGenie] synonym: "up regulation of voltage-gated potassium ion channel activity" EXACT [GOC:TermGenie] synonym: "up regulation of voltage-sensitive potassium channel" EXACT [GOC:TermGenie] synonym: "up-regulation of voltage gated potassium channel activity" EXACT [GOC:TermGenie] synonym: "up-regulation of voltage-dependent potassium channel activity" EXACT [GOC:TermGenie] synonym: "up-regulation of voltage-gated potassium channel activity" EXACT [GOC:TermGenie] synonym: "up-regulation of voltage-gated potassium ion channel activity" EXACT [GOC:TermGenie] synonym: "up-regulation of voltage-sensitive potassium channel" EXACT [GOC:TermGenie] synonym: "upregulation of voltage gated potassium channel activity" EXACT [GOC:TermGenie] synonym: "upregulation of voltage-dependent potassium channel activity" EXACT [GOC:TermGenie] synonym: "upregulation of voltage-gated potassium channel activity" EXACT [GOC:TermGenie] synonym: "upregulation of voltage-gated potassium ion channel activity" EXACT [GOC:TermGenie] synonym: "upregulation of voltage-sensitive potassium channel" EXACT [GOC:TermGenie] is_a: GO:2001259 ! positive regulation of cation channel activity intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0005249 ! positively regulates voltage-gated potassium channel activity relationship: RO:0002213 GO:0005249 ! positively regulates voltage-gated potassium channel activity creation_date: 2015-01-16T17:22:18Z [Term] id: GO:1903828 name: negative regulation of protein localization namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of a protein localization." [GO_REF:0000058, GOC:TermGenie, GOC:vw] synonym: "down regulation of cellular protein localisation" EXACT [GOC:TermGenie] synonym: "down regulation of cellular protein localization" EXACT [GOC:TermGenie] synonym: "down-regulation of cellular protein localisation" EXACT [GOC:TermGenie] synonym: "down-regulation of cellular protein localization" EXACT [GOC:TermGenie] synonym: "downregulation of cellular protein localisation" EXACT [GOC:TermGenie] synonym: "downregulation of cellular protein localization" EXACT [GOC:TermGenie] synonym: "inhibition of cellular protein localisation" NARROW [GOC:TermGenie] synonym: "inhibition of cellular protein localization" NARROW [GOC:TermGenie] synonym: "negative regulation of cellular protein localisation" EXACT [GOC:TermGenie] synonym: "negative regulation of cellular protein localization" EXACT [] is_a: GO:0032880 ! regulation of protein localization is_a: GO:0048519 ! negative regulation of biological process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0008104 ! negatively regulates intracellular protein localization relationship: RO:0002212 GO:0008104 ! negatively regulates intracellular protein localization property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/22021" xsd:anyURI creation_date: 2015-01-20T14:32:24Z [Term] id: GO:1903829 name: positive regulation of protein localization namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of a protein localization." [GO_REF:0000058, GOC:TermGenie, GOC:vw] synonym: "positive regulation of cellular protein localisation" EXACT [GOC:TermGenie] synonym: "positive regulation of cellular protein localization" EXACT [] synonym: "up regulation of cellular protein localisation" EXACT [GOC:TermGenie] synonym: "up regulation of cellular protein localization" EXACT [GOC:TermGenie] synonym: "up-regulation of cellular protein localisation" EXACT [GOC:TermGenie] synonym: "up-regulation of cellular protein localization" EXACT [GOC:TermGenie] synonym: "upregulation of cellular protein localisation" EXACT [GOC:TermGenie] synonym: "upregulation of cellular protein localization" EXACT [GOC:TermGenie] is_a: GO:0032880 ! regulation of protein localization is_a: GO:0048518 ! positive regulation of biological process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0008104 ! positively regulates intracellular protein localization relationship: RO:0002213 GO:0008104 ! positively regulates intracellular protein localization property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/22021" xsd:anyURI creation_date: 2015-01-20T14:32:33Z [Term] id: GO:1903831 name: signal transduction involved in cellular response to ammonium ion namespace: biological_process def: "Any signal transduction that is involved in cellular response to ammonium ion." [GO_REF:0000060, GOC:TermGenie, PMID:16297994] synonym: "signaling cascade involved in cellular response to ammonium ion" NARROW [GOC:TermGenie] synonym: "signaling pathway involved in cellular response to ammonium ion" RELATED [GOC:TermGenie] synonym: "signalling cascade involved in cellular response to ammonium ion" NARROW [GOC:TermGenie] synonym: "signalling pathway involved in cellular response to ammonium ion" RELATED [GOC:TermGenie] is_a: GO:0007165 ! signal transduction intersection_of: GO:0007165 ! signal transduction intersection_of: BFO:0000050 GO:0071242 ! part of cellular response to ammonium ion relationship: BFO:0000050 GO:0071242 ! part of cellular response to ammonium ion creation_date: 2015-01-21T17:52:09Z [Term] id: GO:1903847 name: regulation of aorta morphogenesis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of aorta morphogenesis." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:22269326] is_a: GO:1905651 ! regulation of artery morphogenesis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0035909 ! regulates aorta morphogenesis relationship: RO:0002211 GO:0035909 ! regulates aorta morphogenesis creation_date: 2015-01-23T14:00:51Z [Term] id: GO:1903848 name: negative regulation of aorta morphogenesis namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of aorta morphogenesis." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:22269326] synonym: "down regulation of aorta morphogenesis" EXACT [GOC:TermGenie] synonym: "down-regulation of aorta morphogenesis" EXACT [GOC:TermGenie] synonym: "downregulation of aorta morphogenesis" EXACT [GOC:TermGenie] synonym: "inhibition of aorta morphogenesis" NARROW [GOC:TermGenie] is_a: GO:1903847 ! regulation of aorta morphogenesis is_a: GO:1905652 ! negative regulation of artery morphogenesis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0035909 ! negatively regulates aorta morphogenesis relationship: RO:0002212 GO:0035909 ! negatively regulates aorta morphogenesis creation_date: 2015-01-23T14:01:01Z [Term] id: GO:1903849 name: positive regulation of aorta morphogenesis namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of aorta morphogenesis." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:22269326] synonym: "activation of aorta morphogenesis" NARROW [GOC:TermGenie] synonym: "up regulation of aorta morphogenesis" EXACT [GOC:TermGenie] synonym: "up-regulation of aorta morphogenesis" EXACT [GOC:TermGenie] synonym: "upregulation of aorta morphogenesis" EXACT [GOC:TermGenie] is_a: GO:1903847 ! regulation of aorta morphogenesis is_a: GO:1905653 ! positive regulation of artery morphogenesis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0035909 ! positively regulates aorta morphogenesis relationship: RO:0002213 GO:0035909 ! positively regulates aorta morphogenesis creation_date: 2015-01-23T14:01:09Z [Term] id: GO:1903867 name: extraembryonic membrane development namespace: biological_process def: "The process whose specific outcome is the progression of an extraembryonic membrane over time, from its formation to the mature structure." [GO_REF:0000094, GOC:TermGenie, ISBN:0073040584] is_a: GO:0048856 ! anatomical structure development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0005631 ! results in development of extraembryonic membrane relationship: RO:0002162 NCBITaxon:6072 ! in taxon Eumetazoa relationship: RO:0002296 UBERON:0005631 ! results in development of extraembryonic membrane creation_date: 2015-02-05T00:42:16Z [Term] id: GO:1903903 name: regulation of establishment of T cell polarity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of establishment of T cell polarity." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:23575248] synonym: "regulation of establishment of T lymphocyte polarity" EXACT [GOC:TermGenie] synonym: "regulation of establishment of T-cell polarity" EXACT [GOC:TermGenie] synonym: "regulation of establishment of T-lymphocyte polarity" EXACT [GOC:TermGenie] synonym: "regulation of T cell polarization" EXACT [GOC:TermGenie] synonym: "regulation of T lymphocyte polarization" EXACT [GOC:TermGenie] synonym: "regulation of T-cell polarization" EXACT [GOC:TermGenie] is_a: GO:2000114 ! regulation of establishment of cell polarity intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0001768 ! regulates establishment of T cell polarity relationship: RO:0002211 GO:0001768 ! regulates establishment of T cell polarity creation_date: 2015-02-09T10:50:21Z [Term] id: GO:1903904 name: negative regulation of establishment of T cell polarity namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of establishment of T cell polarity." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:23575248] synonym: "down regulation of establishment of T cell polarity" EXACT [GOC:TermGenie] synonym: "down regulation of establishment of T lymphocyte polarity" EXACT [GOC:TermGenie] synonym: "down regulation of establishment of T-cell polarity" EXACT [GOC:TermGenie] synonym: "down regulation of establishment of T-lymphocyte polarity" EXACT [GOC:TermGenie] synonym: "down regulation of T cell polarization" EXACT [GOC:TermGenie] synonym: "down regulation of T lymphocyte polarization" EXACT [GOC:TermGenie] synonym: "down regulation of T-cell polarization" EXACT [GOC:TermGenie] synonym: "down-regulation of establishment of T cell polarity" EXACT [GOC:TermGenie] synonym: "down-regulation of establishment of T lymphocyte polarity" EXACT [GOC:TermGenie] synonym: "down-regulation of establishment of T-cell polarity" EXACT [GOC:TermGenie] synonym: "down-regulation of establishment of T-lymphocyte polarity" EXACT [GOC:TermGenie] synonym: "down-regulation of T cell polarization" EXACT [GOC:TermGenie] synonym: "down-regulation of T lymphocyte polarization" EXACT [GOC:TermGenie] synonym: "down-regulation of T-cell polarization" EXACT [GOC:TermGenie] synonym: "downregulation of establishment of T cell polarity" EXACT [GOC:TermGenie] synonym: "downregulation of establishment of T lymphocyte polarity" EXACT [GOC:TermGenie] synonym: "downregulation of establishment of T-cell polarity" EXACT [GOC:TermGenie] synonym: "downregulation of establishment of T-lymphocyte polarity" EXACT [GOC:TermGenie] synonym: "downregulation of T cell polarization" EXACT [GOC:TermGenie] synonym: "downregulation of T lymphocyte polarization" EXACT [GOC:TermGenie] synonym: "downregulation of T-cell polarization" EXACT [GOC:TermGenie] synonym: "inhibition of establishment of T cell polarity" NARROW [GOC:TermGenie] synonym: "inhibition of establishment of T lymphocyte polarity" NARROW [GOC:TermGenie] synonym: "inhibition of establishment of T-cell polarity" NARROW [GOC:TermGenie] synonym: "inhibition of establishment of T-lymphocyte polarity" NARROW [GOC:TermGenie] synonym: "inhibition of T cell polarization" NARROW [GOC:TermGenie] synonym: "inhibition of T lymphocyte polarization" NARROW [GOC:TermGenie] synonym: "inhibition of T-cell polarization" NARROW [GOC:TermGenie] synonym: "negative regulation of establishment of T lymphocyte polarity" EXACT [GOC:TermGenie] synonym: "negative regulation of establishment of T-cell polarity" EXACT [GOC:TermGenie] synonym: "negative regulation of establishment of T-lymphocyte polarity" EXACT [GOC:TermGenie] synonym: "negative regulation of T cell polarization" EXACT [GOC:TermGenie] synonym: "negative regulation of T lymphocyte polarization" EXACT [GOC:TermGenie] synonym: "negative regulation of T-cell polarization" EXACT [GOC:TermGenie] is_a: GO:0050868 ! negative regulation of T cell activation is_a: GO:1903903 ! regulation of establishment of T cell polarity intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0001768 ! negatively regulates establishment of T cell polarity relationship: RO:0002212 GO:0001768 ! negatively regulates establishment of T cell polarity creation_date: 2015-02-09T10:50:30Z [Term] id: GO:1903905 name: positive regulation of establishment of T cell polarity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of establishment of T cell polarity." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:23575248] synonym: "activation of establishment of T cell polarity" NARROW [GOC:TermGenie] synonym: "activation of establishment of T lymphocyte polarity" NARROW [GOC:TermGenie] synonym: "activation of establishment of T-cell polarity" NARROW [GOC:TermGenie] synonym: "activation of establishment of T-lymphocyte polarity" NARROW [GOC:TermGenie] synonym: "activation of T cell polarization" NARROW [GOC:TermGenie] synonym: "activation of T lymphocyte polarization" NARROW [GOC:TermGenie] synonym: "activation of T-cell polarization" NARROW [GOC:TermGenie] synonym: "positive regulation of establishment of T lymphocyte polarity" EXACT [GOC:TermGenie] synonym: "positive regulation of establishment of T-cell polarity" EXACT [GOC:TermGenie] synonym: "positive regulation of establishment of T-lymphocyte polarity" EXACT [GOC:TermGenie] synonym: "positive regulation of T cell polarization" EXACT [GOC:TermGenie] synonym: "positive regulation of T lymphocyte polarization" EXACT [GOC:TermGenie] synonym: "positive regulation of T-cell polarization" EXACT [GOC:TermGenie] synonym: "up regulation of establishment of T cell polarity" EXACT [GOC:TermGenie] synonym: "up regulation of establishment of T lymphocyte polarity" EXACT [GOC:TermGenie] synonym: "up regulation of establishment of T-cell polarity" EXACT [GOC:TermGenie] synonym: "up regulation of establishment of T-lymphocyte polarity" EXACT [GOC:TermGenie] synonym: "up regulation of T cell polarization" EXACT [GOC:TermGenie] synonym: "up regulation of T lymphocyte polarization" EXACT [GOC:TermGenie] synonym: "up regulation of T-cell polarization" EXACT [GOC:TermGenie] synonym: "up-regulation of establishment of T cell polarity" EXACT [GOC:TermGenie] synonym: "up-regulation of establishment of T lymphocyte polarity" EXACT [GOC:TermGenie] synonym: "up-regulation of establishment of T-cell polarity" EXACT [GOC:TermGenie] synonym: "up-regulation of establishment of T-lymphocyte polarity" EXACT [GOC:TermGenie] synonym: "up-regulation of T cell polarization" EXACT [GOC:TermGenie] synonym: "up-regulation of T lymphocyte polarization" EXACT [GOC:TermGenie] synonym: "up-regulation of T-cell polarization" EXACT [GOC:TermGenie] synonym: "upregulation of establishment of T cell polarity" EXACT [GOC:TermGenie] synonym: "upregulation of establishment of T lymphocyte polarity" EXACT [GOC:TermGenie] synonym: "upregulation of establishment of T-cell polarity" EXACT [GOC:TermGenie] synonym: "upregulation of establishment of T-lymphocyte polarity" EXACT [GOC:TermGenie] synonym: "upregulation of T cell polarization" EXACT [GOC:TermGenie] synonym: "upregulation of T lymphocyte polarization" EXACT [GOC:TermGenie] synonym: "upregulation of T-cell polarization" EXACT [GOC:TermGenie] is_a: GO:0050870 ! positive regulation of T cell activation is_a: GO:1903903 ! regulation of establishment of T cell polarity intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0001768 ! positively regulates establishment of T cell polarity relationship: RO:0002213 GO:0001768 ! positively regulates establishment of T cell polarity creation_date: 2015-02-09T10:50:40Z [Term] id: GO:1903924 name: estradiol binding namespace: molecular_function def: "Binding to estradiol." [GO_REF:0000067, GOC:TermGenie, PMID:9048584] is_a: GO:0005496 ! steroid binding intersection_of: GO:0005488 ! binding intersection_of: RO:0004009 CHEBI:23965 ! has primary input relationship: RO:0004009 CHEBI:23965 ! has primary input creation_date: 2015-02-11T00:11:34Z [Term] id: GO:1903941 name: negative regulation of respiratory gaseous exchange namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of respiratory gaseous exchange." [GO_REF:0000058, GOC:TermGenie, PMID:22819705] synonym: "down regulation of respiratory gaseous exchange" EXACT [GOC:TermGenie] synonym: "down-regulation of respiratory gaseous exchange" EXACT [GOC:TermGenie] synonym: "downregulation of respiratory gaseous exchange" EXACT [GOC:TermGenie] synonym: "inhibition of respiratory gaseous exchange" NARROW [GOC:TermGenie] is_a: GO:0043576 ! regulation of respiratory gaseous exchange is_a: GO:0051241 ! negative regulation of multicellular organismal process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0007585 ! negatively regulates respiratory gaseous exchange by respiratory system relationship: RO:0002212 GO:0007585 ! negatively regulates respiratory gaseous exchange by respiratory system property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 creation_date: 2015-02-17T20:26:24Z [Term] id: GO:1903942 name: positive regulation of respiratory gaseous exchange namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of respiratory gaseous exchange." [GO_REF:0000058, GOC:TermGenie, PMID:22819705] synonym: "activation of respiratory gaseous exchange" NARROW [GOC:TermGenie] synonym: "up regulation of respiratory gaseous exchange" EXACT [GOC:TermGenie] synonym: "up-regulation of respiratory gaseous exchange" EXACT [GOC:TermGenie] synonym: "upregulation of respiratory gaseous exchange" EXACT [GOC:TermGenie] is_a: GO:0043576 ! regulation of respiratory gaseous exchange is_a: GO:0051240 ! positive regulation of multicellular organismal process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0007585 ! positively regulates respiratory gaseous exchange by respiratory system relationship: RO:0002213 GO:0007585 ! positively regulates respiratory gaseous exchange by respiratory system property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 creation_date: 2015-02-17T20:26:35Z [Term] id: GO:1903943 name: regulation of hepatocyte apoptotic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of hepatocyte apoptotic process." [GO_REF:0000058, GOC:TermGenie, PMID:8649852] synonym: "regulation of hepatocyte apoptosis" NARROW [GOC:TermGenie] is_a: GO:1904035 ! regulation of epithelial cell apoptotic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0097284 ! regulates hepatocyte apoptotic process relationship: RO:0002211 GO:0097284 ! regulates hepatocyte apoptotic process property_value: RO:0002161 NCBITaxon:4751 creation_date: 2015-02-19T12:54:40Z [Term] id: GO:1903944 name: negative regulation of hepatocyte apoptotic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of hepatocyte apoptotic process." [GO_REF:0000058, GOC:TermGenie, PMID:8649852] synonym: "down regulation of hepatocyte apoptosis" NARROW [GOC:TermGenie] synonym: "down regulation of hepatocyte apoptotic process" EXACT [GOC:TermGenie] synonym: "down-regulation of hepatocyte apoptosis" NARROW [GOC:TermGenie] synonym: "down-regulation of hepatocyte apoptotic process" EXACT [GOC:TermGenie] synonym: "downregulation of hepatocyte apoptosis" NARROW [GOC:TermGenie] synonym: "downregulation of hepatocyte apoptotic process" EXACT [GOC:TermGenie] synonym: "inhibition of hepatocyte apoptosis" NARROW [GOC:TermGenie] synonym: "inhibition of hepatocyte apoptotic process" NARROW [GOC:TermGenie] synonym: "negative regulation of hepatocyte apoptosis" NARROW [GOC:TermGenie] is_a: GO:1903943 ! regulation of hepatocyte apoptotic process is_a: GO:1904036 ! negative regulation of epithelial cell apoptotic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0097284 ! negatively regulates hepatocyte apoptotic process relationship: RO:0002212 GO:0097284 ! negatively regulates hepatocyte apoptotic process property_value: RO:0002161 NCBITaxon:4751 creation_date: 2015-02-19T12:54:50Z [Term] id: GO:1903945 name: positive regulation of hepatocyte apoptotic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of hepatocyte apoptotic process." [GO_REF:0000058, GOC:TermGenie, PMID:8649852] synonym: "activation of hepatocyte apoptosis" NARROW [GOC:TermGenie] synonym: "activation of hepatocyte apoptotic process" NARROW [GOC:TermGenie] synonym: "positive regulation of hepatocyte apoptosis" NARROW [GOC:TermGenie] synonym: "up regulation of hepatocyte apoptosis" NARROW [GOC:TermGenie] synonym: "up regulation of hepatocyte apoptotic process" EXACT [GOC:TermGenie] synonym: "up-regulation of hepatocyte apoptosis" NARROW [GOC:TermGenie] synonym: "up-regulation of hepatocyte apoptotic process" EXACT [GOC:TermGenie] synonym: "upregulation of hepatocyte apoptosis" NARROW [GOC:TermGenie] synonym: "upregulation of hepatocyte apoptotic process" EXACT [GOC:TermGenie] is_a: GO:1903943 ! regulation of hepatocyte apoptotic process is_a: GO:1904037 ! positive regulation of epithelial cell apoptotic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0097284 ! positively regulates hepatocyte apoptotic process relationship: RO:0002213 GO:0097284 ! positively regulates hepatocyte apoptotic process property_value: RO:0002161 NCBITaxon:4751 creation_date: 2015-02-19T12:54:59Z [Term] id: GO:1903946 name: negative regulation of ventricular cardiac muscle cell action potential namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of ventricular cardiac muscle cell action potential." [GO_REF:0000058, GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:nc, GOC:TermGenie, PMID:25281747] synonym: "down regulation of ventricular cardiac muscle cell action potential" EXACT [GOC:TermGenie] synonym: "down-regulation of ventricular cardiac muscle cell action potential" EXACT [GOC:TermGenie] synonym: "downregulation of ventricular cardiac muscle cell action potential" EXACT [GOC:TermGenie] synonym: "inhibition of ventricular cardiac muscle cell action potential" NARROW [GOC:TermGenie] is_a: GO:0045759 ! negative regulation of action potential is_a: GO:0098911 ! regulation of ventricular cardiac muscle cell action potential is_a: GO:0106135 ! negative regulation of cardiac muscle cell contraction intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0086005 ! negatively regulates ventricular cardiac muscle cell action potential relationship: RO:0002212 GO:0086005 ! negatively regulates ventricular cardiac muscle cell action potential property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4895 property_value: RO:0002161 NCBITaxon:4932 creation_date: 2015-02-20T14:31:55Z [Term] id: GO:1903947 name: positive regulation of ventricular cardiac muscle cell action potential namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of ventricular cardiac muscle cell action potential." [GO_REF:0000058, GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:nc, GOC:TermGenie, PMID:25281747] synonym: "activation of ventricular cardiac muscle cell action potential" NARROW [GOC:TermGenie] synonym: "up regulation of ventricular cardiac muscle cell action potential" EXACT [GOC:TermGenie] synonym: "up-regulation of ventricular cardiac muscle cell action potential" EXACT [GOC:TermGenie] synonym: "upregulation of ventricular cardiac muscle cell action potential" EXACT [GOC:TermGenie] is_a: GO:0045760 ! positive regulation of action potential is_a: GO:0098911 ! regulation of ventricular cardiac muscle cell action potential is_a: GO:0106134 ! positive regulation of cardiac muscle cell contraction intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0086005 ! positively regulates ventricular cardiac muscle cell action potential relationship: RO:0002213 GO:0086005 ! positively regulates ventricular cardiac muscle cell action potential property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4895 property_value: RO:0002161 NCBITaxon:4932 creation_date: 2015-02-20T14:32:04Z [Term] id: GO:1903948 name: negative regulation of atrial cardiac muscle cell action potential namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of atrial cardiac muscle cell action potential." [GO_REF:0000058, GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:nc, GOC:TermGenie, PMID:25281747] synonym: "down regulation of atrial cardiac muscle cell action potential" EXACT [GOC:TermGenie] synonym: "down-regulation of atrial cardiac muscle cell action potential" EXACT [GOC:TermGenie] synonym: "downregulation of atrial cardiac muscle cell action potential" EXACT [GOC:TermGenie] synonym: "inhibition of atrial cardiac muscle cell action potential" NARROW [GOC:TermGenie] is_a: GO:0045759 ! negative regulation of action potential is_a: GO:0098910 ! regulation of atrial cardiac muscle cell action potential is_a: GO:0106135 ! negative regulation of cardiac muscle cell contraction intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0086014 ! negatively regulates atrial cardiac muscle cell action potential relationship: RO:0002212 GO:0086014 ! negatively regulates atrial cardiac muscle cell action potential property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4895 property_value: RO:0002161 NCBITaxon:4932 creation_date: 2015-02-20T14:36:33Z [Term] id: GO:1903949 name: positive regulation of atrial cardiac muscle cell action potential namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of atrial cardiac muscle cell action potential." [GO_REF:0000058, GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:nc, GOC:TermGenie, PMID:25281747] synonym: "activation of atrial cardiac muscle cell action potential" NARROW [GOC:TermGenie] synonym: "up regulation of atrial cardiac muscle cell action potential" EXACT [GOC:TermGenie] synonym: "up-regulation of atrial cardiac muscle cell action potential" EXACT [GOC:TermGenie] synonym: "upregulation of atrial cardiac muscle cell action potential" EXACT [GOC:TermGenie] is_a: GO:0045760 ! positive regulation of action potential is_a: GO:0098910 ! regulation of atrial cardiac muscle cell action potential intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0086014 ! positively regulates atrial cardiac muscle cell action potential relationship: RO:0002213 GO:0086014 ! positively regulates atrial cardiac muscle cell action potential property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4895 property_value: RO:0002161 NCBITaxon:4932 creation_date: 2015-02-20T14:36:42Z [Term] id: GO:1903950 name: negative regulation of AV node cell action potential namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of AV node cell action potential." [GO_REF:0000058, GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:nc, GOC:TermGenie, PMID:25281747] synonym: "down regulation of atrioventricular node cardiac muscle cell action potential" EXACT [GOC:TermGenie] synonym: "down regulation of AV node cardiac muscle cell action potential" EXACT [GOC:TermGenie] synonym: "down regulation of AV node cell action potential" EXACT [GOC:TermGenie] synonym: "down-regulation of atrioventricular node cardiac muscle cell action potential" EXACT [GOC:TermGenie] synonym: "down-regulation of AV node cardiac muscle cell action potential" EXACT [GOC:TermGenie] synonym: "down-regulation of AV node cell action potential" EXACT [GOC:TermGenie] synonym: "downregulation of atrioventricular node cardiac muscle cell action potential" EXACT [GOC:TermGenie] synonym: "downregulation of AV node cardiac muscle cell action potential" EXACT [GOC:TermGenie] synonym: "downregulation of AV node cell action potential" EXACT [GOC:TermGenie] synonym: "inhibition of atrioventricular node cardiac muscle cell action potential" NARROW [GOC:TermGenie] synonym: "inhibition of AV node cardiac muscle cell action potential" NARROW [GOC:TermGenie] synonym: "inhibition of AV node cell action potential" NARROW [GOC:TermGenie] synonym: "negative regulation of atrioventricular node cardiac muscle cell action potential" EXACT [GOC:TermGenie] synonym: "negative regulation of AV node cardiac muscle cell action potential" EXACT [GOC:TermGenie] is_a: GO:0045759 ! negative regulation of action potential is_a: GO:0098904 ! regulation of AV node cell action potential intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0086016 ! negatively regulates AV node cell action potential relationship: RO:0002212 GO:0086016 ! negatively regulates AV node cell action potential property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4895 property_value: RO:0002161 NCBITaxon:4932 creation_date: 2015-02-20T14:59:41Z [Term] id: GO:1903951 name: positive regulation of AV node cell action potential namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of AV node cell action potential." [GO_REF:0000058, GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:nc, GOC:TermGenie, PMID:25281747] synonym: "activation of atrioventricular node cardiac muscle cell action potential" NARROW [GOC:TermGenie] synonym: "activation of AV node cardiac muscle cell action potential" NARROW [GOC:TermGenie] synonym: "activation of AV node cell action potential" NARROW [GOC:TermGenie] synonym: "positive regulation of atrioventricular node cardiac muscle cell action potential" EXACT [GOC:TermGenie] synonym: "positive regulation of AV node cardiac muscle cell action potential" EXACT [GOC:TermGenie] synonym: "up regulation of atrioventricular node cardiac muscle cell action potential" EXACT [GOC:TermGenie] synonym: "up regulation of AV node cardiac muscle cell action potential" EXACT [GOC:TermGenie] synonym: "up regulation of AV node cell action potential" EXACT [GOC:TermGenie] synonym: "up-regulation of atrioventricular node cardiac muscle cell action potential" EXACT [GOC:TermGenie] synonym: "up-regulation of AV node cardiac muscle cell action potential" EXACT [GOC:TermGenie] synonym: "up-regulation of AV node cell action potential" EXACT [GOC:TermGenie] synonym: "upregulation of atrioventricular node cardiac muscle cell action potential" EXACT [GOC:TermGenie] synonym: "upregulation of AV node cardiac muscle cell action potential" EXACT [GOC:TermGenie] synonym: "upregulation of AV node cell action potential" EXACT [GOC:TermGenie] is_a: GO:0045760 ! positive regulation of action potential is_a: GO:0098904 ! regulation of AV node cell action potential intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0086016 ! positively regulates AV node cell action potential relationship: RO:0002213 GO:0086016 ! positively regulates AV node cell action potential property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4895 property_value: RO:0002161 NCBITaxon:4932 creation_date: 2015-02-20T14:59:50Z [Term] id: GO:1903975 name: regulation of glial cell migration namespace: biological_process def: "Any process that modulates the frequency, rate or extent of glial cell migration." [GO_REF:0000058, GOC:BHF, GOC:nc, GOC:TermGenie, PMID:19100238] synonym: "regulation of glia cell migration" EXACT [GOC:TermGenie] is_a: GO:0030334 ! regulation of cell migration intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0008347 ! regulates glial cell migration relationship: RO:0002211 GO:0008347 ! regulates glial cell migration creation_date: 2015-03-02T15:13:31Z [Term] id: GO:1903976 name: negative regulation of glial cell migration namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of glial cell migration." [GO_REF:0000058, GOC:BHF, GOC:nc, GOC:TermGenie, PMID:19100238] synonym: "down regulation of glia cell migration" EXACT [GOC:TermGenie] synonym: "down regulation of glial cell migration" EXACT [GOC:TermGenie] synonym: "down-regulation of glia cell migration" EXACT [GOC:TermGenie] synonym: "down-regulation of glial cell migration" EXACT [GOC:TermGenie] synonym: "downregulation of glia cell migration" EXACT [GOC:TermGenie] synonym: "downregulation of glial cell migration" EXACT [GOC:TermGenie] synonym: "inhibition of glia cell migration" NARROW [GOC:TermGenie] synonym: "inhibition of glial cell migration" NARROW [GOC:TermGenie] synonym: "negative regulation of glia cell migration" EXACT [GOC:TermGenie] is_a: GO:0030336 ! negative regulation of cell migration is_a: GO:1903975 ! regulation of glial cell migration intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0008347 ! negatively regulates glial cell migration relationship: RO:0002212 GO:0008347 ! negatively regulates glial cell migration creation_date: 2015-03-02T15:13:38Z [Term] id: GO:1903977 name: positive regulation of glial cell migration namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of glial cell migration." [GO_REF:0000058, GOC:BHF, GOC:nc, GOC:TermGenie, PMID:19100238] synonym: "activation of glia cell migration" NARROW [GOC:TermGenie] synonym: "activation of glial cell migration" NARROW [GOC:TermGenie] synonym: "positive regulation of glia cell migration" EXACT [GOC:TermGenie] synonym: "up regulation of glia cell migration" EXACT [GOC:TermGenie] synonym: "up regulation of glial cell migration" EXACT [GOC:TermGenie] synonym: "up-regulation of glia cell migration" EXACT [GOC:TermGenie] synonym: "up-regulation of glial cell migration" EXACT [GOC:TermGenie] synonym: "upregulation of glia cell migration" EXACT [GOC:TermGenie] synonym: "upregulation of glial cell migration" EXACT [GOC:TermGenie] is_a: GO:0030335 ! positive regulation of cell migration is_a: GO:1903975 ! regulation of glial cell migration intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0008347 ! positively regulates glial cell migration relationship: RO:0002213 GO:0008347 ! positively regulates glial cell migration creation_date: 2015-03-02T15:13:43Z [Term] id: GO:1903978 name: regulation of microglial cell activation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of microglial cell activation." [GO_REF:0000058, GOC:BHF, GOC:nc, GOC:TermGenie, PMID:19100238] is_a: GO:0043030 ! regulation of macrophage activation is_a: GO:0150077 ! regulation of neuroinflammatory response intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0001774 ! regulates microglial cell activation relationship: RO:0002211 GO:0001774 ! regulates microglial cell activation creation_date: 2015-03-02T15:17:33Z [Term] id: GO:1903979 name: negative regulation of microglial cell activation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of microglial cell activation." [GO_REF:0000058, GOC:BHF, GOC:nc, GOC:TermGenie, PMID:19100238] synonym: "down regulation of microglial cell activation" EXACT [GOC:TermGenie] synonym: "down-regulation of microglial cell activation" EXACT [GOC:TermGenie] synonym: "downregulation of microglial cell activation" EXACT [GOC:TermGenie] synonym: "inhibition of microglial cell activation" NARROW [GOC:TermGenie] is_a: GO:0043031 ! negative regulation of macrophage activation is_a: GO:0150079 ! negative regulation of neuroinflammatory response is_a: GO:1903978 ! regulation of microglial cell activation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0001774 ! negatively regulates microglial cell activation relationship: RO:0002212 GO:0001774 ! negatively regulates microglial cell activation creation_date: 2015-03-02T15:17:39Z [Term] id: GO:1903980 name: positive regulation of microglial cell activation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of microglial cell activation." [GO_REF:0000058, GOC:BHF, GOC:nc, GOC:TermGenie, PMID:19100238] synonym: "activation of microglial cell activation" NARROW [GOC:TermGenie] synonym: "up regulation of microglial cell activation" EXACT [GOC:TermGenie] synonym: "up-regulation of microglial cell activation" EXACT [GOC:TermGenie] synonym: "upregulation of microglial cell activation" EXACT [GOC:TermGenie] is_a: GO:0043032 ! positive regulation of macrophage activation is_a: GO:0150078 ! positive regulation of neuroinflammatory response is_a: GO:1903978 ! regulation of microglial cell activation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0001774 ! positively regulates microglial cell activation relationship: RO:0002213 GO:0001774 ! positively regulates microglial cell activation creation_date: 2015-03-02T15:17:44Z [Term] id: GO:1903988 name: iron ion export across plasma membrane namespace: biological_process def: "The directed movement of iron ions from inside of a cell, across the plasma membrane and into the extracellular region." [GO_REF:0000074, GOC:BHF, GOC:kom, GOC:rl, GOC:TermGenie, PMID:15514116] comment: An example of this is mouse ferroportin (symbol Slc40a1, UniProtKB identifier: Q9JHI9). synonym: "ferrous iron export" NARROW [] synonym: "ferrous iron export across plasma membrane" NARROW [] synonym: "iron cation export" RELATED [] synonym: "iron(2+) export" RELATED [] is_a: GO:0034755 ! iron ion transmembrane transport is_a: GO:0140115 ! export across plasma membrane intersection_of: GO:0006810 ! transport intersection_of: RO:0002338 GO:0005829 ! has target start location cytosol intersection_of: RO:0002339 GO:0005576 ! has target end location extracellular region intersection_of: RO:0002342 GO:0005886 ! results in transport across plasma membrane intersection_of: RO:0004009 CHEBI:24875 ! has primary input creation_date: 2014-09-03T13:01:37Z [Term] id: GO:1904002 name: regulation of sebum secreting cell proliferation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of sebum secreting cell proliferation." [GO_REF:0000058, GOC:hjd, GOC:TermGenie, PMID:16901790] synonym: "regulation of sebocyte proliferation" RELATED [GOC:TermGenie] is_a: GO:0050678 ! regulation of epithelial cell proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:1990654 ! regulates sebum secreting cell proliferation relationship: RO:0002211 GO:1990654 ! regulates sebum secreting cell proliferation property_value: RO:0002161 NCBITaxon:4751 creation_date: 2015-03-06T16:19:44Z [Term] id: GO:1904003 name: negative regulation of sebum secreting cell proliferation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of sebum secreting cell proliferation." [GO_REF:0000058, GOC:hjd, GOC:TermGenie, PMID:16901790] synonym: "down regulation of sebocyte proliferation" RELATED [GOC:TermGenie] synonym: "down regulation of sebum secreting cell proliferation" EXACT [GOC:TermGenie] synonym: "down-regulation of sebocyte proliferation" RELATED [GOC:TermGenie] synonym: "down-regulation of sebum secreting cell proliferation" EXACT [GOC:TermGenie] synonym: "downregulation of sebocyte proliferation" RELATED [GOC:TermGenie] synonym: "downregulation of sebum secreting cell proliferation" EXACT [GOC:TermGenie] synonym: "inhibition of sebocyte proliferation" RELATED [GOC:TermGenie] synonym: "inhibition of sebum secreting cell proliferation" NARROW [GOC:TermGenie] synonym: "negative regulation of sebocyte proliferation" RELATED [GOC:TermGenie] is_a: GO:0050680 ! negative regulation of epithelial cell proliferation is_a: GO:1904002 ! regulation of sebum secreting cell proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:1990654 ! negatively regulates sebum secreting cell proliferation relationship: RO:0002212 GO:1990654 ! negatively regulates sebum secreting cell proliferation property_value: RO:0002161 NCBITaxon:4751 creation_date: 2015-03-06T16:19:50Z [Term] id: GO:1904004 name: positive regulation of sebum secreting cell proliferation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of sebum secreting cell proliferation." [GO_REF:0000058, GOC:hjd, GOC:TermGenie, PMID:16901790] synonym: "activation of sebocyte proliferation" RELATED [GOC:TermGenie] synonym: "activation of sebum secreting cell proliferation" NARROW [GOC:TermGenie] synonym: "positive regulation of sebocyte proliferation" RELATED [GOC:TermGenie] synonym: "up regulation of sebocyte proliferation" RELATED [GOC:TermGenie] synonym: "up regulation of sebum secreting cell proliferation" EXACT [GOC:TermGenie] synonym: "up-regulation of sebocyte proliferation" RELATED [GOC:TermGenie] synonym: "up-regulation of sebum secreting cell proliferation" EXACT [GOC:TermGenie] synonym: "upregulation of sebocyte proliferation" RELATED [GOC:TermGenie] synonym: "upregulation of sebum secreting cell proliferation" EXACT [GOC:TermGenie] is_a: GO:0050679 ! positive regulation of epithelial cell proliferation is_a: GO:1904002 ! regulation of sebum secreting cell proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:1990654 ! positively regulates sebum secreting cell proliferation relationship: RO:0002213 GO:1990654 ! positively regulates sebum secreting cell proliferation property_value: RO:0002161 NCBITaxon:4751 creation_date: 2015-03-06T16:19:56Z [Term] id: GO:1904014 name: response to serotonin namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a serotonin stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:1505525] is_a: GO:0071867 ! response to monoamine is_a: GO:1901700 ! response to oxygen-containing compound intersection_of: GO:0050896 ! response to stimulus intersection_of: RO:0004009 CHEBI:350546 ! has primary input relationship: RO:0004009 CHEBI:350546 ! has primary input creation_date: 2015-03-06T19:33:54Z [Term] id: GO:1904015 name: cellular response to serotonin namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a serotonin stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:1505525] is_a: GO:0071868 ! cellular response to monoamine stimulus is_a: GO:1901701 ! cellular response to oxygen-containing compound is_a: GO:1904014 ! response to serotonin intersection_of: GO:0070887 ! cellular response to chemical stimulus intersection_of: RO:0004009 CHEBI:350546 ! has primary input creation_date: 2015-03-06T19:34:00Z [Term] id: GO:1904018 name: positive regulation of vasculature development namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of vasculature development." [GO_REF:0000058, GOC:TermGenie, PMID:21472453] synonym: "activation of vascular system development" RELATED [GOC:TermGenie] synonym: "activation of vasculature development" NARROW [GOC:TermGenie] synonym: "positive regulation of vascular system development" RELATED [GOC:TermGenie] synonym: "up regulation of vascular system development" RELATED [GOC:TermGenie] synonym: "up regulation of vasculature development" EXACT [GOC:TermGenie] synonym: "up-regulation of vascular system development" RELATED [GOC:TermGenie] synonym: "up-regulation of vasculature development" EXACT [GOC:TermGenie] synonym: "upregulation of vascular system development" RELATED [GOC:TermGenie] synonym: "upregulation of vasculature development" EXACT [GOC:TermGenie] is_a: GO:0051094 ! positive regulation of developmental process is_a: GO:0051240 ! positive regulation of multicellular organismal process is_a: GO:1901342 ! regulation of vasculature development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0001944 ! positively regulates vasculature development relationship: RO:0002213 GO:0001944 ! positively regulates vasculature development creation_date: 2015-03-06T22:17:04Z [Term] id: GO:1904019 name: epithelial cell apoptotic process namespace: biological_process def: "Any apoptotic process in an epithelial cell." [GO_REF:0000085, GOC:TermGenie, PMID:19137015] synonym: "epithelial cell apoptosis" NARROW [GOC:TermGenie] synonym: "epitheliocyte apoptosis" NARROW [GOC:TermGenie] synonym: "epitheliocyte apoptotic process" EXACT [GOC:TermGenie] is_a: GO:0006915 ! apoptotic process intersection_of: GO:0006915 ! apoptotic process intersection_of: BFO:0000066 CL:0000066 ! occurs in epithelial cell relationship: BFO:0000066 CL:0000066 ! occurs in epithelial cell property_value: RO:0002161 NCBITaxon:4751 creation_date: 2015-03-06T22:27:17Z [Term] id: GO:1904026 name: regulation of collagen fibril organization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of collagen fibril organization." [GO_REF:0000058, GOC:TermGenie, PMID:25451920] synonym: "regulation of collagen fibril organisation" EXACT [GOC:TermGenie] synonym: "regulation of collagen fibrillogenesis" RELATED [] synonym: "regulation of fibrillar collagen organization" EXACT [GOC:TermGenie] is_a: GO:1903053 ! regulation of extracellular matrix organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0030199 ! regulates collagen fibril organization relationship: RO:0002211 GO:0030199 ! regulates collagen fibril organization property_value: RO:0002161 NCBITaxon:4751 creation_date: 2015-03-12T12:36:52Z [Term] id: GO:1904027 name: negative regulation of collagen fibril organization namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of collagen fibril organization." [GO_REF:0000058, GOC:TermGenie, PMID:25451920] synonym: "down regulation of collagen fibril organisation" EXACT [GOC:TermGenie] synonym: "down regulation of collagen fibril organization" EXACT [GOC:TermGenie] synonym: "down regulation of fibrillar collagen organization" EXACT [GOC:TermGenie] synonym: "down-regulation of collagen fibril organisation" EXACT [GOC:TermGenie] synonym: "down-regulation of collagen fibril organization" EXACT [GOC:TermGenie] synonym: "down-regulation of fibrillar collagen organization" EXACT [GOC:TermGenie] synonym: "downregulation of collagen fibril organisation" EXACT [GOC:TermGenie] synonym: "downregulation of collagen fibril organization" EXACT [GOC:TermGenie] synonym: "downregulation of fibrillar collagen organization" EXACT [GOC:TermGenie] synonym: "inhibition of collagen fibril organisation" NARROW [GOC:TermGenie] synonym: "inhibition of collagen fibril organization" NARROW [GOC:TermGenie] synonym: "inhibition of fibrillar collagen organization" NARROW [GOC:TermGenie] synonym: "negative regulation of collagen fibril organisation" EXACT [GOC:TermGenie] synonym: "negative regulation of fibrillar collagen organization" EXACT [GOC:TermGenie] is_a: GO:1903054 ! negative regulation of extracellular matrix organization is_a: GO:1904026 ! regulation of collagen fibril organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0030199 ! negatively regulates collagen fibril organization relationship: RO:0002212 GO:0030199 ! negatively regulates collagen fibril organization property_value: RO:0002161 NCBITaxon:4751 creation_date: 2015-03-12T12:36:59Z [Term] id: GO:1904028 name: positive regulation of collagen fibril organization namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of collagen fibril organization." [GO_REF:0000058, GOC:TermGenie, PMID:25451920] synonym: "activation of collagen fibril organisation" NARROW [GOC:TermGenie] synonym: "activation of collagen fibril organization" NARROW [GOC:TermGenie] synonym: "activation of fibrillar collagen organization" NARROW [GOC:TermGenie] synonym: "positive regulation of collagen fibril organisation" EXACT [GOC:TermGenie] synonym: "positive regulation of fibrillar collagen organization" EXACT [GOC:TermGenie] synonym: "up regulation of collagen fibril organisation" EXACT [GOC:TermGenie] synonym: "up regulation of collagen fibril organization" EXACT [GOC:TermGenie] synonym: "up regulation of fibrillar collagen organization" EXACT [GOC:TermGenie] synonym: "up-regulation of collagen fibril organisation" EXACT [GOC:TermGenie] synonym: "up-regulation of collagen fibril organization" EXACT [GOC:TermGenie] synonym: "up-regulation of fibrillar collagen organization" EXACT [GOC:TermGenie] synonym: "upregulation of collagen fibril organisation" EXACT [GOC:TermGenie] synonym: "upregulation of collagen fibril organization" EXACT [GOC:TermGenie] synonym: "upregulation of fibrillar collagen organization" EXACT [GOC:TermGenie] is_a: GO:1903055 ! positive regulation of extracellular matrix organization is_a: GO:1904026 ! regulation of collagen fibril organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0030199 ! positively regulates collagen fibril organization relationship: RO:0002213 GO:0030199 ! positively regulates collagen fibril organization property_value: RO:0002161 NCBITaxon:4751 creation_date: 2015-03-12T12:37:06Z [Term] id: GO:1904035 name: regulation of epithelial cell apoptotic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of epithelial cell apoptotic process." [GO_REF:0000058, GOC:TermGenie, PMID:19137015] synonym: "regulation of epithelial cell apoptosis" NARROW [GOC:TermGenie] synonym: "regulation of epitheliocyte apoptosis" NARROW [GOC:TermGenie] synonym: "regulation of epitheliocyte apoptotic process" EXACT [GOC:TermGenie] is_a: GO:0042981 ! regulation of apoptotic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:1904019 ! regulates epithelial cell apoptotic process relationship: RO:0002211 GO:1904019 ! regulates epithelial cell apoptotic process property_value: RO:0002161 NCBITaxon:4751 creation_date: 2015-03-13T22:05:41Z [Term] id: GO:1904036 name: negative regulation of epithelial cell apoptotic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of epithelial cell apoptotic process." [GO_REF:0000058, GOC:TermGenie, PMID:19137015] synonym: "down regulation of epithelial cell apoptosis" NARROW [GOC:TermGenie] synonym: "down regulation of epithelial cell apoptotic process" EXACT [GOC:TermGenie] synonym: "down regulation of epitheliocyte apoptosis" NARROW [GOC:TermGenie] synonym: "down regulation of epitheliocyte apoptotic process" EXACT [GOC:TermGenie] synonym: "down-regulation of epithelial cell apoptosis" NARROW [GOC:TermGenie] synonym: "down-regulation of epithelial cell apoptotic process" EXACT [GOC:TermGenie] synonym: "down-regulation of epitheliocyte apoptosis" NARROW [GOC:TermGenie] synonym: "down-regulation of epitheliocyte apoptotic process" EXACT [GOC:TermGenie] synonym: "downregulation of epithelial cell apoptosis" NARROW [GOC:TermGenie] synonym: "downregulation of epithelial cell apoptotic process" EXACT [GOC:TermGenie] synonym: "downregulation of epitheliocyte apoptosis" NARROW [GOC:TermGenie] synonym: "downregulation of epitheliocyte apoptotic process" EXACT [GOC:TermGenie] synonym: "inhibition of epithelial cell apoptosis" NARROW [GOC:TermGenie] synonym: "inhibition of epithelial cell apoptotic process" NARROW [GOC:TermGenie] synonym: "inhibition of epitheliocyte apoptosis" NARROW [GOC:TermGenie] synonym: "inhibition of epitheliocyte apoptotic process" NARROW [GOC:TermGenie] synonym: "negative regulation of epithelial cell apoptosis" NARROW [GOC:TermGenie] synonym: "negative regulation of epitheliocyte apoptosis" NARROW [GOC:TermGenie] synonym: "negative regulation of epitheliocyte apoptotic process" EXACT [GOC:TermGenie] is_a: GO:0043066 ! negative regulation of apoptotic process is_a: GO:1904035 ! regulation of epithelial cell apoptotic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:1904019 ! negatively regulates epithelial cell apoptotic process relationship: RO:0002212 GO:1904019 ! negatively regulates epithelial cell apoptotic process property_value: RO:0002161 NCBITaxon:4751 creation_date: 2015-03-13T22:05:47Z [Term] id: GO:1904037 name: positive regulation of epithelial cell apoptotic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of epithelial cell apoptotic process." [GO_REF:0000058, GOC:TermGenie, PMID:19137015] synonym: "activation of epithelial cell apoptosis" NARROW [GOC:TermGenie] synonym: "activation of epithelial cell apoptotic process" NARROW [GOC:TermGenie] synonym: "activation of epitheliocyte apoptosis" NARROW [GOC:TermGenie] synonym: "activation of epitheliocyte apoptotic process" NARROW [GOC:TermGenie] synonym: "positive regulation of epithelial cell apoptosis" NARROW [GOC:TermGenie] synonym: "positive regulation of epitheliocyte apoptosis" NARROW [GOC:TermGenie] synonym: "positive regulation of epitheliocyte apoptotic process" EXACT [GOC:TermGenie] synonym: "up regulation of epithelial cell apoptosis" NARROW [GOC:TermGenie] synonym: "up regulation of epithelial cell apoptotic process" EXACT [GOC:TermGenie] synonym: "up regulation of epitheliocyte apoptosis" NARROW [GOC:TermGenie] synonym: "up regulation of epitheliocyte apoptotic process" EXACT [GOC:TermGenie] synonym: "up-regulation of epithelial cell apoptosis" NARROW [GOC:TermGenie] synonym: "up-regulation of epithelial cell apoptotic process" EXACT [GOC:TermGenie] synonym: "up-regulation of epitheliocyte apoptosis" NARROW [GOC:TermGenie] synonym: "up-regulation of epitheliocyte apoptotic process" EXACT [GOC:TermGenie] synonym: "upregulation of epithelial cell apoptosis" NARROW [GOC:TermGenie] synonym: "upregulation of epithelial cell apoptotic process" EXACT [GOC:TermGenie] synonym: "upregulation of epitheliocyte apoptosis" NARROW [GOC:TermGenie] synonym: "upregulation of epitheliocyte apoptotic process" EXACT [GOC:TermGenie] is_a: GO:0043065 ! positive regulation of apoptotic process is_a: GO:1904035 ! regulation of epithelial cell apoptotic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:1904019 ! positively regulates epithelial cell apoptotic process relationship: RO:0002213 GO:1904019 ! positively regulates epithelial cell apoptotic process property_value: RO:0002161 NCBITaxon:4751 creation_date: 2015-03-13T22:05:53Z [Term] id: GO:1904038 name: regulation of iron export across plasma membrane namespace: biological_process def: "Any process that modulates the frequency, rate or extent of export of iron ions from inside of a cell, across the plasma membrane and into the extracellular region." [GO_REF:0000058, GOC:BHF, GOC:kom, GOC:TermGenie, PMID:15514116] synonym: "regulation of ferrous iron export" NARROW [] synonym: "regulation of iron(2+) export" NARROW [] is_a: GO:0034759 ! regulation of iron ion transmembrane transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:1903988 ! regulates iron ion export across plasma membrane relationship: RO:0002211 GO:1903988 ! regulates iron ion export across plasma membrane creation_date: 2015-03-16T15:36:37Z [Term] id: GO:1904039 name: negative regulation of iron export across plasma membrane namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of export of iron ions from inside of a cell, across the plasma membrane and into the extracellular region." [GO_REF:0000058, GOC:BHF, GOC:kom, GOC:TermGenie, PMID:15514116] synonym: "down regulation of ferrous iron export" NARROW [GOC:TermGenie] synonym: "down regulation of iron(2+) export" NARROW [GOC:TermGenie] synonym: "down-regulation of ferrous iron export" NARROW [GOC:TermGenie] synonym: "down-regulation of iron(2+) export" NARROW [GOC:TermGenie] synonym: "downregulation of ferrous iron export" NARROW [GOC:TermGenie] synonym: "downregulation of iron(2+) export" NARROW [GOC:TermGenie] synonym: "inhibition of ferrous iron export" NARROW [GOC:TermGenie] synonym: "inhibition of iron(2+) export" NARROW [GOC:TermGenie] synonym: "negative regulation of ferrous iron export" NARROW [GOC:TermGenie] synonym: "negative regulation of iron(2+) export" NARROW [] is_a: GO:0034760 ! negative regulation of iron ion transmembrane transport is_a: GO:1904038 ! regulation of iron export across plasma membrane intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:1903988 ! negatively regulates iron ion export across plasma membrane relationship: RO:0002212 GO:1903988 ! negatively regulates iron ion export across plasma membrane creation_date: 2015-03-16T15:36:43Z [Term] id: GO:1904040 name: positive regulation of iron export across plasma membrane namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of export of iron ions from inside of a cell, across the plasma membrane and into the extracellular region." [GO_REF:0000058, GOC:BHF, GOC:kom, GOC:TermGenie, PMID:15514116] synonym: "activation of ferrous iron export" NARROW [GOC:TermGenie] synonym: "activation of iron(2+) export" NARROW [GOC:TermGenie] synonym: "positive regulation of ferrous iron export" NARROW [GOC:TermGenie] synonym: "positive regulation of iron(2+) export" NARROW [] synonym: "up regulation of ferrous iron export" NARROW [GOC:TermGenie] synonym: "up regulation of iron(2+) export" NARROW [GOC:TermGenie] synonym: "up-regulation of ferrous iron export" NARROW [GOC:TermGenie] synonym: "up-regulation of iron(2+) export" NARROW [GOC:TermGenie] synonym: "upregulation of ferrous iron export" NARROW [GOC:TermGenie] synonym: "upregulation of iron(2+) export" NARROW [GOC:TermGenie] is_a: GO:0034761 ! positive regulation of iron ion transmembrane transport is_a: GO:1904038 ! regulation of iron export across plasma membrane intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:1903988 ! positively regulates iron ion export across plasma membrane relationship: RO:0002213 GO:1903988 ! positively regulates iron ion export across plasma membrane creation_date: 2015-03-16T15:36:49Z [Term] id: GO:1904044 name: response to aldosterone namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an aldosterone stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:17644563] is_a: GO:0051385 ! response to mineralocorticoid is_a: GO:0097305 ! response to alcohol is_a: GO:1901654 ! response to ketone intersection_of: GO:0050896 ! response to stimulus intersection_of: RO:0004009 CHEBI:27584 ! has primary input relationship: RO:0004009 CHEBI:27584 ! has primary input property_value: RO:0002161 NCBITaxon:4751 creation_date: 2015-03-16T23:07:53Z [Term] id: GO:1904045 name: cellular response to aldosterone namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an aldosterone stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:17644563] is_a: GO:0071389 ! cellular response to mineralocorticoid stimulus is_a: GO:0097306 ! cellular response to alcohol is_a: GO:0110096 ! cellular response to aldehyde is_a: GO:1901655 ! cellular response to ketone is_a: GO:1904044 ! response to aldosterone intersection_of: GO:0070887 ! cellular response to chemical stimulus intersection_of: RO:0004009 CHEBI:27584 ! has primary input property_value: RO:0002161 NCBITaxon:4751 creation_date: 2015-03-16T23:07:59Z [Term] id: GO:1904054 name: regulation of cholangiocyte proliferation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cholangiocyte proliferation." [GO_REF:0000058, GOC:TermGenie, PMID:24434010] synonym: "regulation of hepatoblast proliferation" EXACT [GOC:TermGenie] is_a: GO:0050678 ! regulation of epithelial cell proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:1990705 ! regulates cholangiocyte proliferation relationship: RO:0002211 GO:1990705 ! regulates cholangiocyte proliferation property_value: RO:0002161 NCBITaxon:4751 creation_date: 2015-03-18T17:56:14Z [Term] id: GO:1904055 name: negative regulation of cholangiocyte proliferation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of cholangiocyte proliferation." [GO_REF:0000058, GOC:TermGenie, PMID:24434010] synonym: "down regulation of cholangiocyte proliferation" EXACT [GOC:TermGenie] synonym: "down regulation of hepatoblast proliferation" EXACT [GOC:TermGenie] synonym: "down-regulation of cholangiocyte proliferation" EXACT [GOC:TermGenie] synonym: "down-regulation of hepatoblast proliferation" EXACT [GOC:TermGenie] synonym: "downregulation of cholangiocyte proliferation" EXACT [GOC:TermGenie] synonym: "downregulation of hepatoblast proliferation" EXACT [GOC:TermGenie] synonym: "inhibition of cholangiocyte proliferation" NARROW [GOC:TermGenie] synonym: "inhibition of hepatoblast proliferation" NARROW [GOC:TermGenie] synonym: "negative regulation of hepatoblast proliferation" EXACT [GOC:TermGenie] is_a: GO:0050680 ! negative regulation of epithelial cell proliferation is_a: GO:1904054 ! regulation of cholangiocyte proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:1990705 ! negatively regulates cholangiocyte proliferation relationship: RO:0002212 GO:1990705 ! negatively regulates cholangiocyte proliferation property_value: RO:0002161 NCBITaxon:4751 creation_date: 2015-03-18T17:56:20Z [Term] id: GO:1904056 name: positive regulation of cholangiocyte proliferation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cholangiocyte proliferation." [GO_REF:0000058, GOC:TermGenie, PMID:24434010] synonym: "activation of cholangiocyte proliferation" NARROW [GOC:TermGenie] synonym: "activation of hepatoblast proliferation" NARROW [GOC:TermGenie] synonym: "positive regulation of hepatoblast proliferation" EXACT [GOC:TermGenie] synonym: "up regulation of cholangiocyte proliferation" EXACT [GOC:TermGenie] synonym: "up regulation of hepatoblast proliferation" EXACT [GOC:TermGenie] synonym: "up-regulation of cholangiocyte proliferation" EXACT [GOC:TermGenie] synonym: "up-regulation of hepatoblast proliferation" EXACT [GOC:TermGenie] synonym: "upregulation of cholangiocyte proliferation" EXACT [GOC:TermGenie] synonym: "upregulation of hepatoblast proliferation" EXACT [GOC:TermGenie] is_a: GO:0050679 ! positive regulation of epithelial cell proliferation is_a: GO:1904054 ! regulation of cholangiocyte proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:1990705 ! positively regulates cholangiocyte proliferation relationship: RO:0002213 GO:1990705 ! positively regulates cholangiocyte proliferation property_value: RO:0002161 NCBITaxon:4751 creation_date: 2015-03-18T17:56:26Z [Term] id: GO:1904057 name: negative regulation of sensory perception of pain namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of sensory perception of pain." [GO_REF:0000058, GOC:TermGenie, PMID:17167094] synonym: "down regulation of nociception" EXACT [GOC:TermGenie] synonym: "down regulation of perception of physiological pain" NARROW [GOC:TermGenie] synonym: "down regulation of sensory perception of pain" EXACT [GOC:TermGenie] synonym: "down-regulation of nociception" EXACT [GOC:TermGenie] synonym: "down-regulation of perception of physiological pain" NARROW [GOC:TermGenie] synonym: "down-regulation of sensory perception of pain" EXACT [GOC:TermGenie] synonym: "downregulation of nociception" EXACT [GOC:TermGenie] synonym: "downregulation of perception of physiological pain" NARROW [GOC:TermGenie] synonym: "downregulation of sensory perception of pain" EXACT [GOC:TermGenie] synonym: "inhibition of nociception" NARROW [GOC:TermGenie] synonym: "inhibition of perception of physiological pain" NARROW [GOC:TermGenie] synonym: "inhibition of sensory perception of pain" NARROW [GOC:TermGenie] synonym: "negative regulation of nociception" EXACT [GOC:TermGenie] synonym: "negative regulation of perception of physiological pain" NARROW [GOC:TermGenie] is_a: GO:0031645 ! negative regulation of nervous system process is_a: GO:0051930 ! regulation of sensory perception of pain intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0019233 ! negatively regulates sensory perception of pain relationship: RO:0002212 GO:0019233 ! negatively regulates sensory perception of pain creation_date: 2015-03-18T20:33:57Z [Term] id: GO:1904058 name: positive regulation of sensory perception of pain namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of sensory perception of pain." [GO_REF:0000058, GOC:TermGenie, PMID:17167094] synonym: "activation of nociception" NARROW [GOC:TermGenie] synonym: "activation of perception of physiological pain" NARROW [GOC:TermGenie] synonym: "activation of sensory perception of pain" NARROW [GOC:TermGenie] synonym: "positive regulation of nociception" EXACT [GOC:TermGenie] synonym: "positive regulation of perception of physiological pain" NARROW [GOC:TermGenie] synonym: "up regulation of nociception" EXACT [GOC:TermGenie] synonym: "up regulation of perception of physiological pain" NARROW [GOC:TermGenie] synonym: "up regulation of sensory perception of pain" EXACT [GOC:TermGenie] synonym: "up-regulation of nociception" EXACT [GOC:TermGenie] synonym: "up-regulation of perception of physiological pain" NARROW [GOC:TermGenie] synonym: "up-regulation of sensory perception of pain" EXACT [GOC:TermGenie] synonym: "upregulation of nociception" EXACT [GOC:TermGenie] synonym: "upregulation of perception of physiological pain" NARROW [GOC:TermGenie] synonym: "upregulation of sensory perception of pain" EXACT [GOC:TermGenie] is_a: GO:0031646 ! positive regulation of nervous system process is_a: GO:0051930 ! regulation of sensory perception of pain intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0019233 ! positively regulates sensory perception of pain relationship: RO:0002213 GO:0019233 ! positively regulates sensory perception of pain creation_date: 2015-03-18T20:34:03Z [Term] id: GO:1904062 name: regulation of monoatomic cation transmembrane transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cation transmembrane transport." [GO_REF:0000058, GOC:TermGenie, PMID:15304482] synonym: "regulation of cation transmembrane transport" BROAD [] is_a: GO:0034765 ! regulation of monoatomic ion transmembrane transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0098655 ! regulates monoatomic cation transmembrane transport relationship: RO:0002211 GO:0098655 ! regulates monoatomic cation transmembrane transport creation_date: 2015-03-18T21:11:43Z [Term] id: GO:1904063 name: negative regulation of cation transmembrane transport namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of cation transmembrane transport." [GO_REF:0000058, GOC:TermGenie, PMID:15304482] synonym: "down regulation of cation transmembrane transport" EXACT [GOC:TermGenie] synonym: "down-regulation of cation transmembrane transport" EXACT [GOC:TermGenie] synonym: "downregulation of cation transmembrane transport" EXACT [GOC:TermGenie] synonym: "inhibition of cation transmembrane transport" NARROW [GOC:TermGenie] is_a: GO:0034766 ! negative regulation of monoatomic ion transmembrane transport is_a: GO:1904062 ! regulation of monoatomic cation transmembrane transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0098655 ! negatively regulates monoatomic cation transmembrane transport relationship: RO:0002212 GO:0098655 ! negatively regulates monoatomic cation transmembrane transport creation_date: 2015-03-18T21:11:50Z [Term] id: GO:1904064 name: positive regulation of cation transmembrane transport namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cation transmembrane transport." [GO_REF:0000058, GOC:TermGenie, PMID:15304482] synonym: "activation of cation transmembrane transport" NARROW [GOC:TermGenie] synonym: "up regulation of cation transmembrane transport" EXACT [GOC:TermGenie] synonym: "up-regulation of cation transmembrane transport" EXACT [GOC:TermGenie] synonym: "upregulation of cation transmembrane transport" EXACT [GOC:TermGenie] is_a: GO:0034767 ! positive regulation of monoatomic ion transmembrane transport is_a: GO:1904062 ! regulation of monoatomic cation transmembrane transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0098655 ! positively regulates monoatomic cation transmembrane transport relationship: RO:0002213 GO:0098655 ! positively regulates monoatomic cation transmembrane transport creation_date: 2015-03-18T21:11:55Z [Term] id: GO:1904065 name: G protein-coupled acetylcholine receptor signaling pathway involved in positive regulation of acetylcholine secretion, neurotransmission namespace: biological_process def: "Any G protein-coupled acetylcholine receptor signaling pathway that is involved in positive regulation of acetylcholine secretion, neurotransmission." [GO_REF:0000060, GOC:kmv, GOC:TermGenie, PMID:22588719] synonym: "acetylcholine receptor signalling, muscarinic pathway involved in activation of acetylcholine secretion" NARROW [GOC:TermGenie] synonym: "acetylcholine receptor signalling, muscarinic pathway involved in positive regulation of acetylcholine secretion, neurotransmission" EXACT [GOC:TermGenie] synonym: "acetylcholine receptor signalling, muscarinic pathway involved in stimulation of acetylcholine secretion" NARROW [GOC:TermGenie] synonym: "acetylcholine receptor signalling, muscarinic pathway involved in up regulation of acetylcholine secretion" EXACT [GOC:TermGenie] synonym: "acetylcholine receptor signalling, muscarinic pathway involved in up-regulation of acetylcholine secretion" EXACT [GOC:TermGenie] synonym: "acetylcholine receptor signalling, muscarinic pathway involved in upregulation of acetylcholine secretion" EXACT [GOC:TermGenie] synonym: "G-protein coupled acetylcholine receptor signaling pathway involved in activation of acetylcholine secretion" NARROW [GOC:TermGenie] synonym: "G-protein coupled acetylcholine receptor signaling pathway involved in positive regulation of acetylcholine secretion, neurotransmission" EXACT [] synonym: "G-protein coupled acetylcholine receptor signaling pathway involved in stimulation of acetylcholine secretion" NARROW [GOC:TermGenie] synonym: "G-protein coupled acetylcholine receptor signaling pathway involved in up regulation of acetylcholine secretion" EXACT [GOC:TermGenie] synonym: "G-protein coupled acetylcholine receptor signaling pathway involved in up-regulation of acetylcholine secretion" EXACT [GOC:TermGenie] synonym: "G-protein coupled acetylcholine receptor signaling pathway involved in upregulation of acetylcholine secretion" EXACT [GOC:TermGenie] synonym: "muscarinic acetylcholine receptor signaling pathway involved in activation of acetylcholine secretion" NARROW [GOC:TermGenie] synonym: "muscarinic acetylcholine receptor signaling pathway involved in positive regulation of acetylcholine secretion, neurotransmission" EXACT [GOC:TermGenie] synonym: "muscarinic acetylcholine receptor signaling pathway involved in stimulation of acetylcholine secretion" NARROW [GOC:TermGenie] synonym: "muscarinic acetylcholine receptor signaling pathway involved in up regulation of acetylcholine secretion" EXACT [GOC:TermGenie] synonym: "muscarinic acetylcholine receptor signaling pathway involved in up-regulation of acetylcholine secretion" EXACT [GOC:TermGenie] synonym: "muscarinic acetylcholine receptor signaling pathway involved in upregulation of acetylcholine secretion" EXACT [GOC:TermGenie] is_a: GO:0007213 ! G protein-coupled acetylcholine receptor signaling pathway intersection_of: GO:0007213 ! G protein-coupled acetylcholine receptor signaling pathway intersection_of: BFO:0000050 GO:0014057 ! part of positive regulation of acetylcholine secretion, neurotransmission relationship: BFO:0000050 GO:0014057 ! part of positive regulation of acetylcholine secretion, neurotransmission creation_date: 2015-03-19T15:28:47Z [Term] id: GO:1904073 name: regulation of trophectodermal cell proliferation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of trophectodermal cell proliferation." [GO_REF:0000058, GOC:TermGenie, PMID:24508636] synonym: "regulation of trophectoderm cell proliferation" EXACT [GOC:TermGenie] is_a: GO:0042127 ! regulation of cell population proliferation is_a: GO:0048638 ! regulation of developmental growth intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0001834 ! regulates trophectodermal cell proliferation relationship: RO:0002211 GO:0001834 ! regulates trophectodermal cell proliferation creation_date: 2015-03-20T16:55:56Z [Term] id: GO:1904074 name: negative regulation of trophectodermal cell proliferation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of trophectodermal cell proliferation." [GO_REF:0000058, GOC:TermGenie, PMID:24508636] synonym: "down regulation of trophectoderm cell proliferation" EXACT [GOC:TermGenie] synonym: "down regulation of trophectodermal cell proliferation" EXACT [GOC:TermGenie] synonym: "down-regulation of trophectoderm cell proliferation" EXACT [GOC:TermGenie] synonym: "down-regulation of trophectodermal cell proliferation" EXACT [GOC:TermGenie] synonym: "downregulation of trophectoderm cell proliferation" EXACT [GOC:TermGenie] synonym: "downregulation of trophectodermal cell proliferation" EXACT [GOC:TermGenie] synonym: "inhibition of trophectoderm cell proliferation" NARROW [GOC:TermGenie] synonym: "inhibition of trophectodermal cell proliferation" NARROW [GOC:TermGenie] synonym: "negative regulation of trophectoderm cell proliferation" EXACT [GOC:TermGenie] is_a: GO:0008285 ! negative regulation of cell population proliferation is_a: GO:1904073 ! regulation of trophectodermal cell proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0001834 ! negatively regulates trophectodermal cell proliferation relationship: RO:0002212 GO:0001834 ! negatively regulates trophectodermal cell proliferation creation_date: 2015-03-20T16:56:02Z [Term] id: GO:1904075 name: positive regulation of trophectodermal cell proliferation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of trophectodermal cell proliferation." [GO_REF:0000058, GOC:TermGenie, PMID:24508636] synonym: "activation of trophectoderm cell proliferation" NARROW [GOC:TermGenie] synonym: "activation of trophectodermal cell proliferation" NARROW [GOC:TermGenie] synonym: "positive regulation of trophectoderm cell proliferation" EXACT [GOC:TermGenie] synonym: "up regulation of trophectoderm cell proliferation" EXACT [GOC:TermGenie] synonym: "up regulation of trophectodermal cell proliferation" EXACT [GOC:TermGenie] synonym: "up-regulation of trophectoderm cell proliferation" EXACT [GOC:TermGenie] synonym: "up-regulation of trophectodermal cell proliferation" EXACT [GOC:TermGenie] synonym: "upregulation of trophectoderm cell proliferation" EXACT [GOC:TermGenie] synonym: "upregulation of trophectodermal cell proliferation" EXACT [GOC:TermGenie] is_a: GO:0008284 ! positive regulation of cell population proliferation is_a: GO:1904073 ! regulation of trophectodermal cell proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0001834 ! positively regulates trophectodermal cell proliferation relationship: RO:0002213 GO:0001834 ! positively regulates trophectodermal cell proliferation creation_date: 2015-03-20T16:56:08Z [Term] id: GO:1904098 name: regulation of protein O-linked glycosylation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of protein O-linked glycosylation." [GO_REF:0000058, GOC:TermGenie, PMID:24509081] subset: gocheck_obsoletion_candidate synonym: "regulation of protein amino acid O-linked glycosylation" EXACT [GOC:TermGenie] is_a: GO:0010559 ! regulation of glycoprotein biosynthetic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0006493 ! regulates protein O-linked glycosylation relationship: RO:0002211 GO:0006493 ! regulates protein O-linked glycosylation creation_date: 2015-03-27T16:09:58Z [Term] id: GO:1904099 name: negative regulation of protein O-linked glycosylation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein O-linked glycosylation." [GO_REF:0000058, GOC:TermGenie, PMID:24509081] subset: gocheck_obsoletion_candidate synonym: "down regulation of protein amino acid O-linked glycosylation" EXACT [GOC:TermGenie] synonym: "down regulation of protein O-linked glycosylation" EXACT [GOC:TermGenie] synonym: "down-regulation of protein amino acid O-linked glycosylation" EXACT [GOC:TermGenie] synonym: "down-regulation of protein O-linked glycosylation" EXACT [GOC:TermGenie] synonym: "downregulation of protein amino acid O-linked glycosylation" EXACT [GOC:TermGenie] synonym: "downregulation of protein O-linked glycosylation" EXACT [GOC:TermGenie] synonym: "inhibition of protein amino acid O-linked glycosylation" NARROW [GOC:TermGenie] synonym: "inhibition of protein O-linked glycosylation" NARROW [GOC:TermGenie] synonym: "negative regulation of protein amino acid O-linked glycosylation" EXACT [GOC:TermGenie] is_a: GO:0010561 ! negative regulation of glycoprotein biosynthetic process is_a: GO:1904098 ! regulation of protein O-linked glycosylation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0006493 ! negatively regulates protein O-linked glycosylation relationship: RO:0002212 GO:0006493 ! negatively regulates protein O-linked glycosylation creation_date: 2015-03-27T16:10:04Z [Term] id: GO:1904100 name: positive regulation of protein O-linked glycosylation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of protein O-linked glycosylation." [GO_REF:0000058, GOC:TermGenie, PMID:24509081] subset: gocheck_obsoletion_candidate synonym: "activation of protein amino acid O-linked glycosylation" NARROW [GOC:TermGenie] synonym: "activation of protein O-linked glycosylation" NARROW [GOC:TermGenie] synonym: "positive regulation of protein amino acid O-linked glycosylation" EXACT [GOC:TermGenie] synonym: "up regulation of protein amino acid O-linked glycosylation" EXACT [GOC:TermGenie] synonym: "up regulation of protein O-linked glycosylation" EXACT [GOC:TermGenie] synonym: "up-regulation of protein amino acid O-linked glycosylation" EXACT [GOC:TermGenie] synonym: "up-regulation of protein O-linked glycosylation" EXACT [GOC:TermGenie] synonym: "upregulation of protein amino acid O-linked glycosylation" EXACT [GOC:TermGenie] synonym: "upregulation of protein O-linked glycosylation" EXACT [GOC:TermGenie] is_a: GO:0010560 ! positive regulation of glycoprotein biosynthetic process is_a: GO:1904098 ! regulation of protein O-linked glycosylation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0006493 ! positively regulates protein O-linked glycosylation relationship: RO:0002213 GO:0006493 ! positively regulates protein O-linked glycosylation creation_date: 2015-03-27T16:10:10Z [Term] id: GO:1904106 name: protein localization to microvillus namespace: biological_process def: "A process in which a protein is transported to, or maintained in, a location within a microvillus." [GO_REF:0000087, GOC:kmv, GOC:TermGenie, PMID:25335890] synonym: "protein localisation in microvillus" EXACT [GOC:TermGenie] synonym: "protein localisation to microvillus" EXACT [GOC:TermGenie] synonym: "protein localization in microvillus" EXACT [GOC:TermGenie] is_a: GO:0008104 ! intracellular protein localization intersection_of: GO:0008104 ! intracellular protein localization intersection_of: RO:0002339 GO:0005902 ! has target end location microvillus relationship: RO:0002339 GO:0005902 ! has target end location microvillus creation_date: 2015-04-01T18:14:41Z [Term] id: GO:1904115 name: axon cytoplasm namespace: cellular_component def: "Any cytoplasm that is part of a axon." [GO_REF:0000064, GOC:TermGenie, PMID:18667152] synonym: "axoplasm" EXACT [] is_a: GO:0120111 ! neuron projection cytoplasm intersection_of: GO:0005737 ! cytoplasm intersection_of: BFO:0000050 GO:0030424 ! part of axon relationship: BFO:0000050 GO:0030424 ! part of axon property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/14472" xsd:anyURI creation_date: 2015-04-06T18:13:14Z [Term] id: GO:1904116 name: response to vasopressin namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vasopressin stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:22811487] is_a: GO:0043434 ! response to peptide hormone intersection_of: GO:0050896 ! response to stimulus intersection_of: RO:0004009 CHEBI:9937 ! has primary input relationship: RO:0004009 CHEBI:9937 ! has primary input property_value: RO:0002161 NCBITaxon:4751 creation_date: 2015-04-06T19:39:42Z [Term] id: GO:1904117 name: cellular response to vasopressin namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vasopressin stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:22811487] is_a: GO:0071375 ! cellular response to peptide hormone stimulus is_a: GO:1904116 ! response to vasopressin intersection_of: GO:0070887 ! cellular response to chemical stimulus intersection_of: RO:0004009 CHEBI:9937 ! has primary input property_value: RO:0002161 NCBITaxon:4751 creation_date: 2015-04-06T19:39:48Z [Term] id: GO:1904118 name: regulation of otic vesicle morphogenesis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of otic vesicle morphogenesis." [GO_REF:0000058, GOC:TermGenie, PMID:25677106] is_a: GO:1905330 ! regulation of morphogenesis of an epithelium is_a: GO:2000027 ! regulation of animal organ morphogenesis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0071600 ! regulates otic vesicle morphogenesis relationship: RO:0002211 GO:0071600 ! regulates otic vesicle morphogenesis creation_date: 2015-04-07T14:00:56Z [Term] id: GO:1904119 name: negative regulation of otic vesicle morphogenesis namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of otic vesicle morphogenesis." [GO_REF:0000058, GOC:TermGenie, PMID:25677106] synonym: "down regulation of otic vesicle morphogenesis" EXACT [GOC:TermGenie] synonym: "down-regulation of otic vesicle morphogenesis" EXACT [GOC:TermGenie] synonym: "downregulation of otic vesicle morphogenesis" EXACT [GOC:TermGenie] synonym: "inhibition of otic vesicle morphogenesis" NARROW [GOC:TermGenie] is_a: GO:0110111 ! negative regulation of animal organ morphogenesis is_a: GO:1904118 ! regulation of otic vesicle morphogenesis is_a: GO:1905331 ! negative regulation of morphogenesis of an epithelium intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0071600 ! negatively regulates otic vesicle morphogenesis relationship: RO:0002212 GO:0071600 ! negatively regulates otic vesicle morphogenesis creation_date: 2015-04-07T14:01:02Z [Term] id: GO:1904120 name: positive regulation of otic vesicle morphogenesis namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of otic vesicle morphogenesis." [GO_REF:0000058, GOC:TermGenie, PMID:25677106] synonym: "activation of otic vesicle morphogenesis" NARROW [GOC:TermGenie] synonym: "up regulation of otic vesicle morphogenesis" EXACT [GOC:TermGenie] synonym: "up-regulation of otic vesicle morphogenesis" EXACT [GOC:TermGenie] synonym: "upregulation of otic vesicle morphogenesis" EXACT [GOC:TermGenie] is_a: GO:0110110 ! positive regulation of animal organ morphogenesis is_a: GO:1904118 ! regulation of otic vesicle morphogenesis is_a: GO:1905332 ! positive regulation of morphogenesis of an epithelium intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0071600 ! positively regulates otic vesicle morphogenesis relationship: RO:0002213 GO:0071600 ! positively regulates otic vesicle morphogenesis creation_date: 2015-04-07T14:01:08Z [Term] id: GO:1904124 name: microglial cell migration namespace: biological_process def: "The orderly movement of a microglial cell from one site to another." [GO_REF:0000091, GOC:BHF, GOC:nc, GOC:TermGenie, PMID:19100238] is_a: GO:0008347 ! glial cell migration is_a: GO:1905517 ! macrophage migration intersection_of: GO:0016477 ! cell migration intersection_of: RO:0002565 CL:0000129 ! results in movement of microglial cell relationship: RO:0002565 CL:0000129 ! results in movement of microglial cell creation_date: 2015-04-10T16:04:49Z [Term] id: GO:1904139 name: regulation of microglial cell migration namespace: biological_process def: "Any process that modulates the frequency, rate or extent of microglial cell migration." [GO_REF:0000058, GOC:BHF, GOC:nc, GOC:TermGenie, PMID:19100238] is_a: GO:1903975 ! regulation of glial cell migration is_a: GO:1905521 ! regulation of macrophage migration intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:1904124 ! regulates microglial cell migration relationship: RO:0002211 GO:1904124 ! regulates microglial cell migration creation_date: 2015-04-13T09:06:57Z [Term] id: GO:1904140 name: negative regulation of microglial cell migration namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of microglial cell migration." [GO_REF:0000058, GOC:BHF, GOC:nc, GOC:TermGenie, PMID:19100238] synonym: "down regulation of microglial cell migration" EXACT [GOC:TermGenie] synonym: "down-regulation of microglial cell migration" EXACT [GOC:TermGenie] synonym: "downregulation of microglial cell migration" EXACT [GOC:TermGenie] synonym: "inhibition of microglial cell migration" NARROW [GOC:TermGenie] is_a: GO:1903976 ! negative regulation of glial cell migration is_a: GO:1904139 ! regulation of microglial cell migration is_a: GO:1905522 ! negative regulation of macrophage migration intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:1904124 ! negatively regulates microglial cell migration relationship: RO:0002212 GO:1904124 ! negatively regulates microglial cell migration creation_date: 2015-04-13T09:07:03Z [Term] id: GO:1904141 name: positive regulation of microglial cell migration namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of microglial cell migration." [GO_REF:0000058, GOC:BHF, GOC:nc, GOC:TermGenie, PMID:19100238] synonym: "activation of microglial cell migration" NARROW [GOC:TermGenie] synonym: "up regulation of microglial cell migration" EXACT [GOC:TermGenie] synonym: "up-regulation of microglial cell migration" EXACT [GOC:TermGenie] synonym: "upregulation of microglial cell migration" EXACT [GOC:TermGenie] is_a: GO:1903977 ! positive regulation of glial cell migration is_a: GO:1904139 ! regulation of microglial cell migration is_a: GO:1905523 ! positive regulation of macrophage migration intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:1904124 ! positively regulates microglial cell migration relationship: RO:0002213 GO:1904124 ! positively regulates microglial cell migration creation_date: 2015-04-13T09:07:11Z [Term] id: GO:1904142 name: negative regulation of carotenoid biosynthetic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of carotenoid biosynthetic process." [GO_REF:0000058, GOC:TermGenie, PMID:25675505] synonym: "down regulation of carotenoid anabolism" EXACT [GOC:TermGenie] synonym: "down regulation of carotenoid biosynthesis" EXACT [GOC:TermGenie] synonym: "down regulation of carotenoid biosynthetic process" EXACT [GOC:TermGenie] synonym: "down regulation of carotenoid formation" EXACT [GOC:TermGenie] synonym: "down regulation of carotenoid synthesis" EXACT [GOC:TermGenie] synonym: "down-regulation of carotenoid anabolism" EXACT [GOC:TermGenie] synonym: "down-regulation of carotenoid biosynthesis" EXACT [GOC:TermGenie] synonym: "down-regulation of carotenoid biosynthetic process" EXACT [GOC:TermGenie] synonym: "down-regulation of carotenoid formation" EXACT [GOC:TermGenie] synonym: "down-regulation of carotenoid synthesis" EXACT [GOC:TermGenie] synonym: "downregulation of carotenoid anabolism" EXACT [GOC:TermGenie] synonym: "downregulation of carotenoid biosynthesis" EXACT [GOC:TermGenie] synonym: "downregulation of carotenoid biosynthetic process" EXACT [GOC:TermGenie] synonym: "downregulation of carotenoid formation" EXACT [GOC:TermGenie] synonym: "downregulation of carotenoid synthesis" EXACT [GOC:TermGenie] synonym: "inhibition of carotenoid anabolism" NARROW [GOC:TermGenie] synonym: "inhibition of carotenoid biosynthesis" NARROW [GOC:TermGenie] synonym: "inhibition of carotenoid biosynthetic process" NARROW [GOC:TermGenie] synonym: "inhibition of carotenoid formation" NARROW [GOC:TermGenie] synonym: "inhibition of carotenoid synthesis" NARROW [GOC:TermGenie] synonym: "negative regulation of carotenoid anabolism" EXACT [GOC:TermGenie] synonym: "negative regulation of carotenoid biosynthesis" EXACT [GOC:TermGenie] synonym: "negative regulation of carotenoid formation" EXACT [GOC:TermGenie] synonym: "negative regulation of carotenoid synthesis" EXACT [GOC:TermGenie] is_a: GO:0045827 ! negative regulation of isoprenoid metabolic process is_a: GO:0051055 ! negative regulation of lipid biosynthetic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0016117 ! negatively regulates carotenoid biosynthetic process relationship: RO:0002212 GO:0016117 ! negatively regulates carotenoid biosynthetic process property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 creation_date: 2015-04-13T19:39:13Z [Term] id: GO:1904143 name: positive regulation of carotenoid biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of carotenoid biosynthetic process." [GO_REF:0000058, GOC:TermGenie, PMID:25675505] synonym: "activation of carotenoid anabolism" NARROW [GOC:TermGenie] synonym: "activation of carotenoid biosynthesis" NARROW [GOC:TermGenie] synonym: "activation of carotenoid biosynthetic process" NARROW [GOC:TermGenie] synonym: "activation of carotenoid formation" NARROW [GOC:TermGenie] synonym: "activation of carotenoid synthesis" NARROW [GOC:TermGenie] synonym: "positive regulation of carotenoid anabolism" EXACT [GOC:TermGenie] synonym: "positive regulation of carotenoid biosynthesis" EXACT [GOC:TermGenie] synonym: "positive regulation of carotenoid formation" EXACT [GOC:TermGenie] synonym: "positive regulation of carotenoid synthesis" EXACT [GOC:TermGenie] synonym: "up regulation of carotenoid anabolism" EXACT [GOC:TermGenie] synonym: "up regulation of carotenoid biosynthesis" EXACT [GOC:TermGenie] synonym: "up regulation of carotenoid biosynthetic process" EXACT [GOC:TermGenie] synonym: "up regulation of carotenoid formation" EXACT [GOC:TermGenie] synonym: "up regulation of carotenoid synthesis" EXACT [GOC:TermGenie] synonym: "up-regulation of carotenoid anabolism" EXACT [GOC:TermGenie] synonym: "up-regulation of carotenoid biosynthesis" EXACT [GOC:TermGenie] synonym: "up-regulation of carotenoid biosynthetic process" EXACT [GOC:TermGenie] synonym: "up-regulation of carotenoid formation" EXACT [GOC:TermGenie] synonym: "up-regulation of carotenoid synthesis" EXACT [GOC:TermGenie] synonym: "upregulation of carotenoid anabolism" EXACT [GOC:TermGenie] synonym: "upregulation of carotenoid biosynthesis" EXACT [GOC:TermGenie] synonym: "upregulation of carotenoid biosynthetic process" EXACT [GOC:TermGenie] synonym: "upregulation of carotenoid formation" EXACT [GOC:TermGenie] synonym: "upregulation of carotenoid synthesis" EXACT [GOC:TermGenie] is_a: GO:0019747 ! regulation of isoprenoid metabolic process is_a: GO:0046889 ! positive regulation of lipid biosynthetic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0016117 ! positively regulates carotenoid biosynthetic process relationship: RO:0002213 GO:0016117 ! positively regulates carotenoid biosynthetic process property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 creation_date: 2015-04-13T19:39:19Z [Term] id: GO:1904145 name: negative regulation of meiotic cell cycle process involved in oocyte maturation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of meiotic cell cycle process involved in oocyte maturation." [GO_REF:0000058, GOC:TermGenie, PMID:22674394] synonym: "down regulation of meiotic cell cycle process involved in oocyte maturation" EXACT [GOC:TermGenie] synonym: "down-regulation of meiotic cell cycle process involved in oocyte maturation" EXACT [GOC:TermGenie] synonym: "downregulation of meiotic cell cycle process involved in oocyte maturation" EXACT [GOC:TermGenie] synonym: "inhibition of meiotic cell cycle process involved in oocyte maturation" NARROW [GOC:TermGenie] is_a: GO:0010948 ! negative regulation of cell cycle process is_a: GO:0051447 ! negative regulation of meiotic cell cycle is_a: GO:1900194 ! negative regulation of oocyte maturation is_a: GO:1903538 ! regulation of meiotic cell cycle process involved in oocyte maturation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:1903537 ! negatively regulates meiotic cell cycle process involved in oocyte maturation relationship: RO:0002212 GO:1903537 ! negatively regulates meiotic cell cycle process involved in oocyte maturation creation_date: 2015-04-14T15:59:22Z [Term] id: GO:1904146 name: positive regulation of meiotic cell cycle process involved in oocyte maturation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of meiotic cell cycle process involved in oocyte maturation." [GO_REF:0000058, GOC:TermGenie, PMID:22674394] synonym: "activation of meiotic cell cycle process involved in oocyte maturation" NARROW [GOC:TermGenie] synonym: "up regulation of meiotic cell cycle process involved in oocyte maturation" EXACT [GOC:TermGenie] synonym: "up-regulation of meiotic cell cycle process involved in oocyte maturation" EXACT [GOC:TermGenie] synonym: "upregulation of meiotic cell cycle process involved in oocyte maturation" EXACT [GOC:TermGenie] is_a: GO:0051446 ! positive regulation of meiotic cell cycle is_a: GO:0090068 ! positive regulation of cell cycle process is_a: GO:1903538 ! regulation of meiotic cell cycle process involved in oocyte maturation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:1903537 ! positively regulates meiotic cell cycle process involved in oocyte maturation relationship: RO:0002213 GO:1903537 ! positively regulates meiotic cell cycle process involved in oocyte maturation creation_date: 2015-04-14T15:59:28Z [Term] id: GO:1904149 name: regulation of microglial cell mediated cytotoxicity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of microglial cell mediated cytotoxicity." [GO_REF:0000058, GOC:BHF, GOC:nc, GOC:TermGenie, PMID:19100238] is_a: GO:0001910 ! regulation of leukocyte mediated cytotoxicity is_a: GO:0002886 ! regulation of myeloid leukocyte mediated immunity intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0090634 ! regulates microglial cell mediated cytotoxicity relationship: RO:0002211 GO:0090634 ! regulates microglial cell mediated cytotoxicity creation_date: 2015-04-15T08:05:29Z [Term] id: GO:1904150 name: negative regulation of microglial cell mediated cytotoxicity namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of microglial cell mediated cytotoxicity." [GO_REF:0000058, GOC:BHF, GOC:nc, GOC:TermGenie, PMID:19100238] synonym: "down regulation of microglial cell mediated cytotoxicity" EXACT [GOC:TermGenie] synonym: "down-regulation of microglial cell mediated cytotoxicity" EXACT [GOC:TermGenie] synonym: "downregulation of microglial cell mediated cytotoxicity" EXACT [GOC:TermGenie] synonym: "inhibition of microglial cell mediated cytotoxicity" NARROW [GOC:TermGenie] is_a: GO:0001911 ! negative regulation of leukocyte mediated cytotoxicity is_a: GO:0002887 ! negative regulation of myeloid leukocyte mediated immunity is_a: GO:1904149 ! regulation of microglial cell mediated cytotoxicity intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0090634 ! negatively regulates microglial cell mediated cytotoxicity relationship: RO:0002212 GO:0090634 ! negatively regulates microglial cell mediated cytotoxicity creation_date: 2015-04-15T08:05:35Z [Term] id: GO:1904151 name: positive regulation of microglial cell mediated cytotoxicity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of microglial cell mediated cytotoxicity." [GO_REF:0000058, GOC:BHF, GOC:nc, GOC:TermGenie, PMID:19100238] synonym: "activation of microglial cell mediated cytotoxicity" NARROW [GOC:TermGenie] synonym: "up regulation of microglial cell mediated cytotoxicity" EXACT [GOC:TermGenie] synonym: "up-regulation of microglial cell mediated cytotoxicity" EXACT [GOC:TermGenie] synonym: "upregulation of microglial cell mediated cytotoxicity" EXACT [GOC:TermGenie] is_a: GO:0001912 ! positive regulation of leukocyte mediated cytotoxicity is_a: GO:0002888 ! positive regulation of myeloid leukocyte mediated immunity is_a: GO:1904149 ! regulation of microglial cell mediated cytotoxicity intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0090634 ! positively regulates microglial cell mediated cytotoxicity relationship: RO:0002213 GO:0090634 ! positively regulates microglial cell mediated cytotoxicity creation_date: 2015-04-15T08:05:42Z [Term] id: GO:1904155 name: DN2 thymocyte differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires the specialized features of a DN2 thymocyte. A DN2 thymocyte is a CD4-,CD8- thymocyte that is also CD44+,CD25-." [GO_REF:0000086, GOC:dph, GOC:TermGenie, PMID:25398325] is_a: GO:0033077 ! T cell differentiation in thymus intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000806 ! results in acquisition of features of DN2 thymocyte relationship: RO:0002315 CL:0000806 ! results in acquisition of features of DN2 thymocyte creation_date: 2015-04-15T12:52:53Z [Term] id: GO:1904156 name: DN3 thymocyte differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires the specialized features of a DN3 thymocyte. A DN3 thymocyte is a CD4-,CD8- thymocyte that is also CD44+,CD25+." [GO_REF:0000086, GOC:dph, GOC:TermGenie, PMID:25398325] is_a: GO:0033077 ! T cell differentiation in thymus intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000807 ! results in acquisition of features of DN3 thymocyte relationship: RO:0002315 CL:0000807 ! results in acquisition of features of DN3 thymocyte creation_date: 2015-04-15T12:53:00Z [Term] id: GO:1904157 name: DN4 thymocyte differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires the specialized features of a DN4 thymocyte. A DN4 thymocyte is a CD4-,CD8- thymocyte that is also CD44-,CD25-." [GO_REF:0000086, GOC:dph, GOC:TermGenie, PMID:25398325] is_a: GO:0033077 ! T cell differentiation in thymus intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000808 ! results in acquisition of features of DN4 thymocyte relationship: RO:0002315 CL:0000808 ! results in acquisition of features of DN4 thymocyte creation_date: 2015-04-15T12:53:07Z [Term] id: GO:1904158 name: axonemal central apparatus assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form an axonemal central apparatus." [GO_REF:0000079, GOC:cilia, GOC:krc, GOC:TermGenie, PMID:9295136] synonym: "axonemal central apparatus formation" EXACT [GOC:TermGenie] is_a: GO:0022607 ! cellular component assembly intersection_of: GO:0022607 ! cellular component assembly intersection_of: RO:0002588 GO:1990716 ! results in assembly of axonemal central apparatus relationship: BFO:0000050 GO:0035082 ! part of axoneme assembly relationship: RO:0002588 GO:1990716 ! results in assembly of axonemal central apparatus property_value: RO:0002161 NCBITaxon:3176 property_value: RO:0002161 NCBITaxon:3378 property_value: RO:0002161 NCBITaxon:3398 property_value: RO:0002161 NCBITaxon:4890 property_value: RO:0002161 NCBITaxon:5782 creation_date: 2015-04-16T18:46:11Z [Term] id: GO:1904170 name: regulation of bleb assembly namespace: biological_process def: "Any process that modulates the frequency, rate or extent of bleb assembly." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:25651887] synonym: "regulation of cell blebbing" EXACT [GOC:TermGenie] is_a: GO:0120032 ! regulation of plasma membrane bounded cell projection assembly intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0032060 ! regulates bleb assembly relationship: RO:0002211 GO:0032060 ! regulates bleb assembly creation_date: 2015-04-23T09:32:19Z [Term] id: GO:1904171 name: negative regulation of bleb assembly namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of bleb assembly." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:25651887] synonym: "down regulation of bleb assembly" EXACT [GOC:TermGenie] synonym: "down regulation of cell blebbing" EXACT [GOC:TermGenie] synonym: "down-regulation of bleb assembly" EXACT [GOC:TermGenie] synonym: "down-regulation of cell blebbing" EXACT [GOC:TermGenie] synonym: "downregulation of bleb assembly" EXACT [GOC:TermGenie] synonym: "downregulation of cell blebbing" EXACT [GOC:TermGenie] synonym: "inhibition of bleb assembly" NARROW [GOC:TermGenie] synonym: "inhibition of cell blebbing" NARROW [GOC:TermGenie] synonym: "negative regulation of cell blebbing" EXACT [GOC:TermGenie] is_a: GO:0120033 ! negative regulation of plasma membrane bounded cell projection assembly is_a: GO:1904170 ! regulation of bleb assembly intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0032060 ! negatively regulates bleb assembly relationship: RO:0002212 GO:0032060 ! negatively regulates bleb assembly creation_date: 2015-04-23T09:32:25Z [Term] id: GO:1904172 name: positive regulation of bleb assembly namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of bleb assembly." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:25651887] synonym: "activation of bleb assembly" NARROW [GOC:TermGenie] synonym: "activation of cell blebbing" NARROW [GOC:TermGenie] synonym: "positive regulation of cell blebbing" EXACT [GOC:TermGenie] synonym: "up regulation of bleb assembly" EXACT [GOC:TermGenie] synonym: "up regulation of cell blebbing" EXACT [GOC:TermGenie] synonym: "up-regulation of bleb assembly" EXACT [GOC:TermGenie] synonym: "up-regulation of cell blebbing" EXACT [GOC:TermGenie] synonym: "upregulation of bleb assembly" EXACT [GOC:TermGenie] synonym: "upregulation of cell blebbing" EXACT [GOC:TermGenie] is_a: GO:0120034 ! positive regulation of plasma membrane bounded cell projection assembly is_a: GO:1904170 ! regulation of bleb assembly intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0032060 ! positively regulates bleb assembly relationship: RO:0002213 GO:0032060 ! positively regulates bleb assembly creation_date: 2015-04-23T09:32:31Z [Term] id: GO:1904177 name: regulation of adipose tissue development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of adipose tissue development." [GO_REF:0000058, GOC:TermGenie, PMID:23081848] synonym: "regulation of adipogenesis" RELATED [GOC:TermGenie] xref: Reactome:R-HSA-9843745 "Adipogenesis" is_a: GO:0050793 ! regulation of developmental process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0060612 ! regulates adipose tissue development relationship: RO:0002211 GO:0060612 ! regulates adipose tissue development creation_date: 2015-04-29T20:01:01Z [Term] id: GO:1904178 name: negative regulation of adipose tissue development namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of adipose tissue development." [GO_REF:0000058, GOC:TermGenie, PMID:23081848] synonym: "down regulation of adipogenesis" RELATED [GOC:TermGenie] synonym: "down regulation of adipose tissue development" EXACT [GOC:TermGenie] synonym: "down-regulation of adipogenesis" RELATED [GOC:TermGenie] synonym: "down-regulation of adipose tissue development" EXACT [GOC:TermGenie] synonym: "downregulation of adipogenesis" RELATED [GOC:TermGenie] synonym: "downregulation of adipose tissue development" EXACT [GOC:TermGenie] synonym: "inhibition of adipogenesis" RELATED [GOC:TermGenie] synonym: "inhibition of adipose tissue development" NARROW [GOC:TermGenie] synonym: "negative regulation of adipogenesis" RELATED [GOC:TermGenie] is_a: GO:0051093 ! negative regulation of developmental process is_a: GO:0051241 ! negative regulation of multicellular organismal process is_a: GO:1904177 ! regulation of adipose tissue development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0060612 ! negatively regulates adipose tissue development relationship: RO:0002212 GO:0060612 ! negatively regulates adipose tissue development creation_date: 2015-04-29T20:01:07Z [Term] id: GO:1904179 name: positive regulation of adipose tissue development namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of adipose tissue development." [GO_REF:0000058, GOC:TermGenie, PMID:23081848] synonym: "activation of adipogenesis" RELATED [GOC:TermGenie] synonym: "activation of adipose tissue development" NARROW [GOC:TermGenie] synonym: "positive regulation of adipogenesis" RELATED [GOC:TermGenie] synonym: "up regulation of adipogenesis" RELATED [GOC:TermGenie] synonym: "up regulation of adipose tissue development" EXACT [GOC:TermGenie] synonym: "up-regulation of adipogenesis" RELATED [GOC:TermGenie] synonym: "up-regulation of adipose tissue development" EXACT [GOC:TermGenie] synonym: "upregulation of adipogenesis" RELATED [GOC:TermGenie] synonym: "upregulation of adipose tissue development" EXACT [GOC:TermGenie] is_a: GO:0051094 ! positive regulation of developmental process is_a: GO:0051240 ! positive regulation of multicellular organismal process is_a: GO:1904177 ! regulation of adipose tissue development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0060612 ! positively regulates adipose tissue development relationship: RO:0002213 GO:0060612 ! positively regulates adipose tissue development creation_date: 2015-04-29T20:01:13Z [Term] id: GO:1904180 name: negative regulation of membrane depolarization namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of membrane depolarization." [GO_REF:0000058, GOC:TermGenie, PMID:20826763] synonym: "down regulation of membrane depolarization" EXACT [GOC:TermGenie] synonym: "down-regulation of membrane depolarization" EXACT [GOC:TermGenie] synonym: "downregulation of membrane depolarization" EXACT [GOC:TermGenie] synonym: "inhibition of membrane depolarization" NARROW [GOC:TermGenie] is_a: GO:0003254 ! regulation of membrane depolarization is_a: GO:0048519 ! negative regulation of biological process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0051899 ! negatively regulates membrane depolarization relationship: RO:0002212 GO:0051899 ! negatively regulates membrane depolarization creation_date: 2015-04-29T22:29:25Z [Term] id: GO:1904181 name: positive regulation of membrane depolarization namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of membrane depolarization." [GO_REF:0000058, GOC:TermGenie, PMID:20826763] synonym: "activation of membrane depolarization" NARROW [GOC:TermGenie] synonym: "up regulation of membrane depolarization" EXACT [GOC:TermGenie] synonym: "up-regulation of membrane depolarization" EXACT [GOC:TermGenie] synonym: "upregulation of membrane depolarization" EXACT [GOC:TermGenie] is_a: GO:0003254 ! regulation of membrane depolarization is_a: GO:0048518 ! positive regulation of biological process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0051899 ! positively regulates membrane depolarization relationship: RO:0002213 GO:0051899 ! positively regulates membrane depolarization creation_date: 2015-04-29T22:29:31Z [Term] id: GO:1904192 name: regulation of cholangiocyte apoptotic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cholangiocyte apoptotic process." [GO_REF:0000058, GOC:TermGenie, PMID:24498161] synonym: "regulation of cholangiocyte apoptosis" NARROW [GOC:TermGenie] synonym: "regulation of epithelial cell of bile duct apoptosis" NARROW [GOC:TermGenie] synonym: "regulation of epithelial cell of bile duct apoptotic process" EXACT [GOC:TermGenie] is_a: GO:1904035 ! regulation of epithelial cell apoptotic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:1902488 ! regulates cholangiocyte apoptotic process relationship: RO:0002211 GO:1902488 ! regulates cholangiocyte apoptotic process property_value: RO:0002161 NCBITaxon:4751 creation_date: 2015-05-06T15:25:48Z [Term] id: GO:1904193 name: negative regulation of cholangiocyte apoptotic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of cholangiocyte apoptotic process." [GO_REF:0000058, GOC:TermGenie, PMID:24498161] synonym: "down regulation of cholangiocyte apoptosis" NARROW [GOC:TermGenie] synonym: "down regulation of cholangiocyte apoptotic process" EXACT [GOC:TermGenie] synonym: "down regulation of epithelial cell of bile duct apoptosis" NARROW [GOC:TermGenie] synonym: "down regulation of epithelial cell of bile duct apoptotic process" EXACT [GOC:TermGenie] synonym: "down-regulation of cholangiocyte apoptosis" NARROW [GOC:TermGenie] synonym: "down-regulation of cholangiocyte apoptotic process" EXACT [GOC:TermGenie] synonym: "down-regulation of epithelial cell of bile duct apoptosis" NARROW [GOC:TermGenie] synonym: "down-regulation of epithelial cell of bile duct apoptotic process" EXACT [GOC:TermGenie] synonym: "downregulation of cholangiocyte apoptosis" NARROW [GOC:TermGenie] synonym: "downregulation of cholangiocyte apoptotic process" EXACT [GOC:TermGenie] synonym: "downregulation of epithelial cell of bile duct apoptosis" NARROW [GOC:TermGenie] synonym: "downregulation of epithelial cell of bile duct apoptotic process" EXACT [GOC:TermGenie] synonym: "inhibition of cholangiocyte apoptosis" NARROW [GOC:TermGenie] synonym: "inhibition of cholangiocyte apoptotic process" NARROW [GOC:TermGenie] synonym: "inhibition of epithelial cell of bile duct apoptosis" NARROW [GOC:TermGenie] synonym: "inhibition of epithelial cell of bile duct apoptotic process" NARROW [GOC:TermGenie] synonym: "negative regulation of cholangiocyte apoptosis" NARROW [GOC:TermGenie] synonym: "negative regulation of epithelial cell of bile duct apoptosis" NARROW [GOC:TermGenie] synonym: "negative regulation of epithelial cell of bile duct apoptotic process" EXACT [GOC:TermGenie] is_a: GO:1904036 ! negative regulation of epithelial cell apoptotic process is_a: GO:1904192 ! regulation of cholangiocyte apoptotic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:1902488 ! negatively regulates cholangiocyte apoptotic process relationship: RO:0002212 GO:1902488 ! negatively regulates cholangiocyte apoptotic process property_value: RO:0002161 NCBITaxon:4751 creation_date: 2015-05-06T15:25:55Z [Term] id: GO:1904194 name: positive regulation of cholangiocyte apoptotic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cholangiocyte apoptotic process." [GO_REF:0000058, GOC:TermGenie, PMID:24498161] synonym: "activation of cholangiocyte apoptosis" NARROW [GOC:TermGenie] synonym: "activation of cholangiocyte apoptotic process" NARROW [GOC:TermGenie] synonym: "activation of epithelial cell of bile duct apoptosis" NARROW [GOC:TermGenie] synonym: "activation of epithelial cell of bile duct apoptotic process" NARROW [GOC:TermGenie] synonym: "positive regulation of cholangiocyte apoptosis" NARROW [GOC:TermGenie] synonym: "positive regulation of epithelial cell of bile duct apoptosis" NARROW [GOC:TermGenie] synonym: "positive regulation of epithelial cell of bile duct apoptotic process" EXACT [GOC:TermGenie] synonym: "up regulation of cholangiocyte apoptosis" NARROW [GOC:TermGenie] synonym: "up regulation of cholangiocyte apoptotic process" EXACT [GOC:TermGenie] synonym: "up regulation of epithelial cell of bile duct apoptosis" NARROW [GOC:TermGenie] synonym: "up regulation of epithelial cell of bile duct apoptotic process" EXACT [GOC:TermGenie] synonym: "up-regulation of cholangiocyte apoptosis" NARROW [GOC:TermGenie] synonym: "up-regulation of cholangiocyte apoptotic process" EXACT [GOC:TermGenie] synonym: "up-regulation of epithelial cell of bile duct apoptosis" NARROW [GOC:TermGenie] synonym: "up-regulation of epithelial cell of bile duct apoptotic process" EXACT [GOC:TermGenie] synonym: "upregulation of cholangiocyte apoptosis" NARROW [GOC:TermGenie] synonym: "upregulation of cholangiocyte apoptotic process" EXACT [GOC:TermGenie] synonym: "upregulation of epithelial cell of bile duct apoptosis" NARROW [GOC:TermGenie] synonym: "upregulation of epithelial cell of bile duct apoptotic process" EXACT [GOC:TermGenie] is_a: GO:1904037 ! positive regulation of epithelial cell apoptotic process is_a: GO:1904192 ! regulation of cholangiocyte apoptotic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:1902488 ! positively regulates cholangiocyte apoptotic process relationship: RO:0002213 GO:1902488 ! positively regulates cholangiocyte apoptotic process property_value: RO:0002161 NCBITaxon:4751 creation_date: 2015-05-06T15:26:00Z [Term] id: GO:1904195 name: regulation of granulosa cell proliferation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of granulosa cell proliferation." [GO_REF:0000058, GOC:TermGenie, PMID:22383759] is_a: GO:0050678 ! regulation of epithelial cell proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:1990739 ! regulates granulosa cell proliferation relationship: RO:0002211 GO:1990739 ! regulates granulosa cell proliferation property_value: RO:0002161 NCBITaxon:4751 creation_date: 2015-05-07T17:02:25Z [Term] id: GO:1904196 name: negative regulation of granulosa cell proliferation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of granulosa cell proliferation." [GO_REF:0000058, GOC:TermGenie, PMID:22383759] synonym: "down regulation of granulosa cell proliferation" EXACT [GOC:TermGenie] synonym: "down-regulation of granulosa cell proliferation" EXACT [GOC:TermGenie] synonym: "downregulation of granulosa cell proliferation" EXACT [GOC:TermGenie] synonym: "inhibition of granulosa cell proliferation" NARROW [GOC:TermGenie] is_a: GO:0050680 ! negative regulation of epithelial cell proliferation is_a: GO:1904195 ! regulation of granulosa cell proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:1990739 ! negatively regulates granulosa cell proliferation relationship: RO:0002212 GO:1990739 ! negatively regulates granulosa cell proliferation property_value: RO:0002161 NCBITaxon:4751 creation_date: 2015-05-07T17:02:34Z [Term] id: GO:1904197 name: positive regulation of granulosa cell proliferation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of granulosa cell proliferation." [GO_REF:0000058, GOC:TermGenie, PMID:22383759] synonym: "activation of granulosa cell proliferation" NARROW [GOC:TermGenie] synonym: "up regulation of granulosa cell proliferation" EXACT [GOC:TermGenie] synonym: "up-regulation of granulosa cell proliferation" EXACT [GOC:TermGenie] synonym: "upregulation of granulosa cell proliferation" EXACT [GOC:TermGenie] is_a: GO:0050679 ! positive regulation of epithelial cell proliferation is_a: GO:1904195 ! regulation of granulosa cell proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:1990739 ! positively regulates granulosa cell proliferation relationship: RO:0002213 GO:1990739 ! positively regulates granulosa cell proliferation property_value: RO:0002161 NCBITaxon:4751 creation_date: 2015-05-07T17:02:40Z [Term] id: GO:1904204 name: regulation of skeletal muscle hypertrophy namespace: biological_process def: "Any process that modulates the frequency, rate or extent of skeletal muscle hypertrophy." [GO_REF:0000058, GOC:TermGenie, PMID:23470307] is_a: GO:0014733 ! regulation of skeletal muscle adaptation is_a: GO:0014743 ! regulation of muscle hypertrophy intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0014734 ! regulates skeletal muscle hypertrophy relationship: RO:0002211 GO:0014734 ! regulates skeletal muscle hypertrophy property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 creation_date: 2015-05-08T17:38:13Z [Term] id: GO:1904205 name: negative regulation of skeletal muscle hypertrophy namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of skeletal muscle hypertrophy." [GO_REF:0000058, GOC:TermGenie, PMID:23470307] synonym: "down regulation of skeletal muscle hypertrophy" EXACT [GOC:TermGenie] synonym: "down-regulation of skeletal muscle hypertrophy" EXACT [GOC:TermGenie] synonym: "downregulation of skeletal muscle hypertrophy" EXACT [GOC:TermGenie] synonym: "inhibition of skeletal muscle hypertrophy" NARROW [GOC:TermGenie] is_a: GO:0014741 ! negative regulation of muscle hypertrophy is_a: GO:0014745 ! negative regulation of muscle adaptation is_a: GO:1904204 ! regulation of skeletal muscle hypertrophy intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0014734 ! negatively regulates skeletal muscle hypertrophy relationship: RO:0002212 GO:0014734 ! negatively regulates skeletal muscle hypertrophy property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 creation_date: 2015-05-08T17:38:19Z [Term] id: GO:1904206 name: positive regulation of skeletal muscle hypertrophy namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of skeletal muscle hypertrophy." [GO_REF:0000058, GOC:TermGenie, PMID:23470307] synonym: "activation of skeletal muscle hypertrophy" NARROW [GOC:TermGenie] synonym: "up regulation of skeletal muscle hypertrophy" EXACT [GOC:TermGenie] synonym: "up-regulation of skeletal muscle hypertrophy" EXACT [GOC:TermGenie] synonym: "upregulation of skeletal muscle hypertrophy" EXACT [GOC:TermGenie] is_a: GO:0014742 ! positive regulation of muscle hypertrophy is_a: GO:0014744 ! positive regulation of muscle adaptation is_a: GO:1904204 ! regulation of skeletal muscle hypertrophy intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0014734 ! positively regulates skeletal muscle hypertrophy relationship: RO:0002213 GO:0014734 ! positively regulates skeletal muscle hypertrophy property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 creation_date: 2015-05-08T17:38:25Z [Term] id: GO:1904215 name: regulation of protein import into chloroplast stroma namespace: biological_process def: "Any process that modulates the frequency, rate or extent of protein import into chloroplast stroma." [GO_REF:0000058, GOC:TermGenie, PMID:25901327] synonym: "regulation of chloroplast stroma protein import" EXACT [GOC:TermGenie] synonym: "regulation of protein transport into chloroplast stroma" EXACT [GOC:TermGenie] is_a: GO:0034762 ! regulation of transmembrane transport is_a: GO:0051223 ! regulation of protein transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0045037 ! regulates protein import into chloroplast stroma relationship: RO:0002211 GO:0045037 ! regulates protein import into chloroplast stroma creation_date: 2015-05-15T00:47:48Z [Term] id: GO:1904216 name: positive regulation of protein import into chloroplast stroma namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of protein import into chloroplast stroma." [GO_REF:0000058, GOC:TermGenie, PMID:25901327] synonym: "activation of chloroplast stroma protein import" NARROW [GOC:TermGenie] synonym: "activation of protein import into chloroplast stroma" NARROW [GOC:TermGenie] synonym: "activation of protein transport into chloroplast stroma" NARROW [GOC:TermGenie] synonym: "positive regulation of chloroplast stroma protein import" EXACT [GOC:TermGenie] synonym: "positive regulation of protein transport into chloroplast stroma" EXACT [GOC:TermGenie] synonym: "up regulation of chloroplast stroma protein import" EXACT [GOC:TermGenie] synonym: "up regulation of protein import into chloroplast stroma" EXACT [GOC:TermGenie] synonym: "up regulation of protein transport into chloroplast stroma" EXACT [GOC:TermGenie] synonym: "up-regulation of chloroplast stroma protein import" EXACT [GOC:TermGenie] synonym: "up-regulation of protein import into chloroplast stroma" EXACT [GOC:TermGenie] synonym: "up-regulation of protein transport into chloroplast stroma" EXACT [GOC:TermGenie] synonym: "upregulation of chloroplast stroma protein import" EXACT [GOC:TermGenie] synonym: "upregulation of protein import into chloroplast stroma" EXACT [GOC:TermGenie] synonym: "upregulation of protein transport into chloroplast stroma" EXACT [GOC:TermGenie] is_a: GO:0034764 ! positive regulation of transmembrane transport is_a: GO:0051222 ! positive regulation of protein transport is_a: GO:1904215 ! regulation of protein import into chloroplast stroma intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0045037 ! positively regulates protein import into chloroplast stroma relationship: RO:0002213 GO:0045037 ! positively regulates protein import into chloroplast stroma creation_date: 2015-05-15T00:47:55Z [Term] id: GO:1904238 name: pericyte cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires the specialized features of a pericyte cell." [GO_REF:0000086, GOC:dph, GOC:TermGenie, PMID:23868830] is_a: GO:0030154 ! cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000669 ! results in acquisition of features of pericyte relationship: RO:0002315 CL:0000669 ! results in acquisition of features of pericyte creation_date: 2015-05-15T14:50:13Z [Term] id: GO:1904266 name: regulation of Schwann cell chemotaxis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of Schwann cell chemotaxis." [GO_REF:0000058, GOC:TermGenie, PMID:16203995] is_a: GO:0050920 ! regulation of chemotaxis is_a: GO:1900147 ! regulation of Schwann cell migration intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:1990751 ! regulates Schwann cell chemotaxis relationship: RO:0002211 GO:1990751 ! regulates Schwann cell chemotaxis creation_date: 2015-05-28T17:47:41Z [Term] id: GO:1904267 name: negative regulation of Schwann cell chemotaxis namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of Schwann cell chemotaxis." [GO_REF:0000058, GOC:TermGenie, PMID:16203995] synonym: "down regulation of Schwann cell chemotaxis" EXACT [GOC:TermGenie] synonym: "down-regulation of Schwann cell chemotaxis" EXACT [GOC:TermGenie] synonym: "downregulation of Schwann cell chemotaxis" EXACT [GOC:TermGenie] synonym: "inhibition of Schwann cell chemotaxis" NARROW [GOC:TermGenie] is_a: GO:0050922 ! negative regulation of chemotaxis is_a: GO:1900148 ! negative regulation of Schwann cell migration is_a: GO:1904266 ! regulation of Schwann cell chemotaxis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:1990751 ! negatively regulates Schwann cell chemotaxis relationship: RO:0002212 GO:1990751 ! negatively regulates Schwann cell chemotaxis creation_date: 2015-05-28T17:47:48Z [Term] id: GO:1904268 name: positive regulation of Schwann cell chemotaxis namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of Schwann cell chemotaxis." [GO_REF:0000058, GOC:TermGenie, PMID:16203995] synonym: "activation of Schwann cell chemotaxis" NARROW [GOC:TermGenie] synonym: "up regulation of Schwann cell chemotaxis" EXACT [GOC:TermGenie] synonym: "up-regulation of Schwann cell chemotaxis" EXACT [GOC:TermGenie] synonym: "upregulation of Schwann cell chemotaxis" EXACT [GOC:TermGenie] is_a: GO:0050921 ! positive regulation of chemotaxis is_a: GO:1900149 ! positive regulation of Schwann cell migration is_a: GO:1904266 ! regulation of Schwann cell chemotaxis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:1990751 ! positively regulates Schwann cell chemotaxis relationship: RO:0002213 GO:1990751 ! positively regulates Schwann cell chemotaxis creation_date: 2015-05-28T17:47:55Z [Term] id: GO:1904269 name: cell leading edge cell cortex namespace: cellular_component def: "The cell cortex of the leading edge of a cell." [GO_REF:0000064, GOC:kmv, GOC:TermGenie, PMID:25843030] synonym: "cell cortex of cell leading edge" EXACT [GOC:TermGenie] synonym: "cell cortex of front of cell" EXACT [GOC:TermGenie] synonym: "cell cortex of leading edge of cell" EXACT [GOC:TermGenie] synonym: "cell periphery of cell leading edge" RELATED [GOC:TermGenie] synonym: "cell periphery of front of cell" RELATED [GOC:TermGenie] synonym: "cell periphery of leading edge of cell" RELATED [GOC:TermGenie] synonym: "peripheral cytoplasm of cell leading edge" RELATED [GOC:TermGenie] synonym: "peripheral cytoplasm of front of cell" RELATED [GOC:TermGenie] synonym: "peripheral cytoplasm of leading edge of cell" RELATED [GOC:TermGenie] is_a: GO:0099738 ! cell cortex region intersection_of: GO:0099738 ! cell cortex region intersection_of: BFO:0000050 GO:0031252 ! part of cell leading edge relationship: BFO:0000050 GO:0031252 ! part of cell leading edge property_value: RO:0002161 NCBITaxon:4751 creation_date: 2015-05-28T19:16:03Z [Term] id: GO:1904304 name: regulation of gastro-intestinal system smooth muscle contraction namespace: biological_process def: "Any process that modulates the frequency, rate or extent of gastro-intestinal system smooth muscle contraction." [GO_REF:0000058, GOC:TermGenie, PMID:10821044] is_a: GO:0006940 ! regulation of smooth muscle contraction intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0014831 ! regulates gastro-intestinal system smooth muscle contraction relationship: RO:0002211 GO:0014831 ! regulates gastro-intestinal system smooth muscle contraction property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 creation_date: 2015-06-09T23:18:42Z [Term] id: GO:1904305 name: negative regulation of gastro-intestinal system smooth muscle contraction namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of gastro-intestinal system smooth muscle contraction." [GO_REF:0000058, GOC:TermGenie, PMID:10821044] synonym: "down regulation of gastro-intestinal system smooth muscle contraction" EXACT [GOC:TermGenie] synonym: "down-regulation of gastro-intestinal system smooth muscle contraction" EXACT [GOC:TermGenie] synonym: "downregulation of gastro-intestinal system smooth muscle contraction" EXACT [GOC:TermGenie] synonym: "inhibition of gastro-intestinal system smooth muscle contraction" NARROW [GOC:TermGenie] is_a: GO:0045986 ! negative regulation of smooth muscle contraction is_a: GO:1904304 ! regulation of gastro-intestinal system smooth muscle contraction intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0014831 ! negatively regulates gastro-intestinal system smooth muscle contraction relationship: RO:0002212 GO:0014831 ! negatively regulates gastro-intestinal system smooth muscle contraction property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 creation_date: 2015-06-09T23:18:48Z [Term] id: GO:1904306 name: positive regulation of gastro-intestinal system smooth muscle contraction namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of gastro-intestinal system smooth muscle contraction." [GO_REF:0000058, GOC:TermGenie, PMID:10821044] synonym: "activation of gastro-intestinal system smooth muscle contraction" NARROW [GOC:TermGenie] synonym: "up regulation of gastro-intestinal system smooth muscle contraction" EXACT [GOC:TermGenie] synonym: "up-regulation of gastro-intestinal system smooth muscle contraction" EXACT [GOC:TermGenie] synonym: "upregulation of gastro-intestinal system smooth muscle contraction" EXACT [GOC:TermGenie] is_a: GO:0045987 ! positive regulation of smooth muscle contraction is_a: GO:1904304 ! regulation of gastro-intestinal system smooth muscle contraction intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0014831 ! positively regulates gastro-intestinal system smooth muscle contraction relationship: RO:0002213 GO:0014831 ! positively regulates gastro-intestinal system smooth muscle contraction property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 creation_date: 2015-06-09T23:18:54Z [Term] id: GO:1904315 name: transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential namespace: molecular_function def: "Any transmitter-gated ion channel activity that is involved in regulation of postsynaptic membrane potential." [GO_REF:0000061, GOC:TermGenie, PMID:20200227] subset: goslim_synapse synonym: "ionotropic neurotransmitter receptor activity involved in regulation of post-synaptic membrane potential" NARROW [GOC:TermGenie] synonym: "ionotropic neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential" NARROW [GOC:TermGenie] synonym: "transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential" BROAD [] is_a: GO:0022824 ! transmitter-gated monoatomic ion channel activity is_a: GO:0099529 ! neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential intersection_of: GO:0022824 ! transmitter-gated monoatomic ion channel activity intersection_of: BFO:0000050 GO:0060078 ! part of regulation of postsynaptic membrane potential creation_date: 2015-06-10T18:02:07Z [Term] id: GO:1904318 name: regulation of smooth muscle contraction involved in micturition namespace: biological_process def: "Any process that modulates the frequency, rate or extent of smooth muscle contraction involved in micturition." [GO_REF:0000058, GOC:TermGenie, PMID:18562635] synonym: "regulation of smooth muscle contraction involved in urination" RELATED [GOC:TermGenie] synonym: "regulation of urinary bladder smooth muscle contraction involved in micturition" RELATED [GOC:TermGenie] is_a: GO:0006940 ! regulation of smooth muscle contraction is_a: GO:0044062 ! regulation of excretion is_a: GO:0098801 ! regulation of renal system process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0060083 ! regulates smooth muscle contraction involved in micturition relationship: RO:0002211 GO:0060083 ! regulates smooth muscle contraction involved in micturition property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 property_value: RO:0002161 NCBITaxon:8782 creation_date: 2015-06-10T18:46:11Z [Term] id: GO:1904319 name: negative regulation of smooth muscle contraction involved in micturition namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of smooth muscle contraction involved in micturition." [GO_REF:0000058, GOC:TermGenie, PMID:18562635] synonym: "down regulation of smooth muscle contraction involved in micturition" EXACT [GOC:TermGenie] synonym: "down regulation of smooth muscle contraction involved in urination" RELATED [GOC:TermGenie] synonym: "down regulation of urinary bladder smooth muscle contraction involved in micturition" RELATED [GOC:TermGenie] synonym: "down-regulation of smooth muscle contraction involved in micturition" EXACT [GOC:TermGenie] synonym: "down-regulation of smooth muscle contraction involved in urination" RELATED [GOC:TermGenie] synonym: "down-regulation of urinary bladder smooth muscle contraction involved in micturition" RELATED [GOC:TermGenie] synonym: "downregulation of smooth muscle contraction involved in micturition" EXACT [GOC:TermGenie] synonym: "downregulation of smooth muscle contraction involved in urination" RELATED [GOC:TermGenie] synonym: "downregulation of urinary bladder smooth muscle contraction involved in micturition" RELATED [GOC:TermGenie] synonym: "inhibition of smooth muscle contraction involved in micturition" NARROW [GOC:TermGenie] synonym: "inhibition of smooth muscle contraction involved in urination" RELATED [GOC:TermGenie] synonym: "inhibition of urinary bladder smooth muscle contraction involved in micturition" RELATED [GOC:TermGenie] synonym: "negative regulation of smooth muscle contraction involved in urination" RELATED [GOC:TermGenie] synonym: "negative regulation of urinary bladder smooth muscle contraction involved in micturition" RELATED [GOC:TermGenie] is_a: GO:0045986 ! negative regulation of smooth muscle contraction is_a: GO:1904318 ! regulation of smooth muscle contraction involved in micturition intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0060083 ! negatively regulates smooth muscle contraction involved in micturition relationship: RO:0002212 GO:0060083 ! negatively regulates smooth muscle contraction involved in micturition property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 property_value: RO:0002161 NCBITaxon:8782 creation_date: 2015-06-10T18:46:17Z [Term] id: GO:1904320 name: positive regulation of smooth muscle contraction involved in micturition namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of smooth muscle contraction involved in micturition." [GO_REF:0000058, GOC:TermGenie, PMID:18562635] synonym: "activation of smooth muscle contraction involved in micturition" NARROW [GOC:TermGenie] synonym: "activation of smooth muscle contraction involved in urination" RELATED [GOC:TermGenie] synonym: "activation of urinary bladder smooth muscle contraction involved in micturition" RELATED [GOC:TermGenie] synonym: "positive regulation of smooth muscle contraction involved in urination" RELATED [GOC:TermGenie] synonym: "positive regulation of urinary bladder smooth muscle contraction involved in micturition" RELATED [GOC:TermGenie] synonym: "up regulation of smooth muscle contraction involved in micturition" EXACT [GOC:TermGenie] synonym: "up regulation of smooth muscle contraction involved in urination" RELATED [GOC:TermGenie] synonym: "up regulation of urinary bladder smooth muscle contraction involved in micturition" RELATED [GOC:TermGenie] synonym: "up-regulation of smooth muscle contraction involved in micturition" EXACT [GOC:TermGenie] synonym: "up-regulation of smooth muscle contraction involved in urination" RELATED [GOC:TermGenie] synonym: "up-regulation of urinary bladder smooth muscle contraction involved in micturition" RELATED [GOC:TermGenie] synonym: "upregulation of smooth muscle contraction involved in micturition" EXACT [GOC:TermGenie] synonym: "upregulation of smooth muscle contraction involved in urination" RELATED [GOC:TermGenie] synonym: "upregulation of urinary bladder smooth muscle contraction involved in micturition" RELATED [GOC:TermGenie] is_a: GO:0045987 ! positive regulation of smooth muscle contraction is_a: GO:1904318 ! regulation of smooth muscle contraction involved in micturition intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0060083 ! positively regulates smooth muscle contraction involved in micturition relationship: RO:0002213 GO:0060083 ! positively regulates smooth muscle contraction involved in micturition property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 property_value: RO:0002161 NCBITaxon:8782 creation_date: 2015-06-10T18:46:23Z [Term] id: GO:1904338 name: regulation of dopaminergic neuron differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of dopaminergic neuron differentiation." [GO_REF:0000058, GOC:TermGenie, PMID:15522889] is_a: GO:0045664 ! regulation of neuron differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0071542 ! regulates dopaminergic neuron differentiation relationship: RO:0002211 GO:0071542 ! regulates dopaminergic neuron differentiation creation_date: 2015-06-11T18:06:19Z [Term] id: GO:1904339 name: negative regulation of dopaminergic neuron differentiation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of dopaminergic neuron differentiation." [GO_REF:0000058, GOC:TermGenie, PMID:15522889] synonym: "down regulation of dopaminergic neuron differentiation" EXACT [GOC:TermGenie] synonym: "down-regulation of dopaminergic neuron differentiation" EXACT [GOC:TermGenie] synonym: "downregulation of dopaminergic neuron differentiation" EXACT [GOC:TermGenie] synonym: "inhibition of dopaminergic neuron differentiation" NARROW [GOC:TermGenie] is_a: GO:0045665 ! negative regulation of neuron differentiation is_a: GO:1904338 ! regulation of dopaminergic neuron differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0071542 ! negatively regulates dopaminergic neuron differentiation relationship: RO:0002212 GO:0071542 ! negatively regulates dopaminergic neuron differentiation creation_date: 2015-06-11T18:06:25Z [Term] id: GO:1904340 name: positive regulation of dopaminergic neuron differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of dopaminergic neuron differentiation." [GO_REF:0000058, GOC:TermGenie, PMID:15522889] synonym: "activation of dopaminergic neuron differentiation" NARROW [GOC:TermGenie] synonym: "up regulation of dopaminergic neuron differentiation" EXACT [GOC:TermGenie] synonym: "up-regulation of dopaminergic neuron differentiation" EXACT [GOC:TermGenie] synonym: "upregulation of dopaminergic neuron differentiation" EXACT [GOC:TermGenie] is_a: GO:0045666 ! positive regulation of neuron differentiation is_a: GO:1904338 ! regulation of dopaminergic neuron differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0071542 ! positively regulates dopaminergic neuron differentiation relationship: RO:0002213 GO:0071542 ! positively regulates dopaminergic neuron differentiation creation_date: 2015-06-11T18:06:32Z [Term] id: GO:1904341 name: regulation of colon smooth muscle contraction namespace: biological_process def: "Any process that modulates the frequency, rate or extent of colon smooth muscle contraction." [GO_REF:0000058, GOC:TermGenie, PMID:24170253] is_a: GO:1904304 ! regulation of gastro-intestinal system smooth muscle contraction intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:1990765 ! regulates colon smooth muscle contraction relationship: RO:0002211 GO:1990765 ! regulates colon smooth muscle contraction creation_date: 2015-06-11T21:16:58Z [Term] id: GO:1904342 name: negative regulation of colon smooth muscle contraction namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of colon smooth muscle contraction." [GO_REF:0000058, GOC:TermGenie, PMID:24170253] synonym: "down regulation of colon smooth muscle contraction" EXACT [GOC:TermGenie] synonym: "down-regulation of colon smooth muscle contraction" EXACT [GOC:TermGenie] synonym: "downregulation of colon smooth muscle contraction" EXACT [GOC:TermGenie] synonym: "inhibition of colon smooth muscle contraction" NARROW [GOC:TermGenie] is_a: GO:1904305 ! negative regulation of gastro-intestinal system smooth muscle contraction is_a: GO:1904341 ! regulation of colon smooth muscle contraction intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:1990765 ! negatively regulates colon smooth muscle contraction relationship: RO:0002212 GO:1990765 ! negatively regulates colon smooth muscle contraction creation_date: 2015-06-11T21:17:05Z [Term] id: GO:1904343 name: positive regulation of colon smooth muscle contraction namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of colon smooth muscle contraction." [GO_REF:0000058, GOC:TermGenie, PMID:24170253] synonym: "activation of colon smooth muscle contraction" NARROW [GOC:TermGenie] synonym: "up regulation of colon smooth muscle contraction" EXACT [GOC:TermGenie] synonym: "up-regulation of colon smooth muscle contraction" EXACT [GOC:TermGenie] synonym: "upregulation of colon smooth muscle contraction" EXACT [GOC:TermGenie] is_a: GO:1904306 ! positive regulation of gastro-intestinal system smooth muscle contraction is_a: GO:1904341 ! regulation of colon smooth muscle contraction intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:1990765 ! positively regulates colon smooth muscle contraction relationship: RO:0002213 GO:1990765 ! positively regulates colon smooth muscle contraction creation_date: 2015-06-11T21:17:11Z [Term] id: GO:1904344 name: regulation of gastric mucosal blood circulation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of gastric mucosal blood circulation." [GO_REF:0000058, GOC:TermGenie, PMID:10807413] synonym: "regulation of stomach mucosal blood circulation" EXACT [GOC:TermGenie] is_a: GO:1903522 ! regulation of blood circulation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:1990768 ! regulates gastric mucosal blood circulation relationship: RO:0002211 GO:1990768 ! regulates gastric mucosal blood circulation property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 creation_date: 2015-06-11T21:20:31Z [Term] id: GO:1904345 name: negative regulation of gastric mucosal blood circulation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of gastric mucosal blood circulation." [GO_REF:0000058, GOC:TermGenie, PMID:10807413] synonym: "down regulation of gastric mucosal blood circulation" EXACT [GOC:TermGenie] synonym: "down regulation of stomach mucosal blood circulation" EXACT [GOC:TermGenie] synonym: "down-regulation of gastric mucosal blood circulation" EXACT [GOC:TermGenie] synonym: "down-regulation of stomach mucosal blood circulation" EXACT [GOC:TermGenie] synonym: "downregulation of gastric mucosal blood circulation" EXACT [GOC:TermGenie] synonym: "downregulation of stomach mucosal blood circulation" EXACT [GOC:TermGenie] synonym: "inhibition of gastric mucosal blood circulation" NARROW [GOC:TermGenie] synonym: "inhibition of stomach mucosal blood circulation" NARROW [GOC:TermGenie] synonym: "negative regulation of stomach mucosal blood circulation" EXACT [GOC:TermGenie] is_a: GO:1903523 ! negative regulation of blood circulation is_a: GO:1904344 ! regulation of gastric mucosal blood circulation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:1990768 ! negatively regulates gastric mucosal blood circulation relationship: RO:0002212 GO:1990768 ! negatively regulates gastric mucosal blood circulation property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 creation_date: 2015-06-11T21:20:44Z [Term] id: GO:1904346 name: positive regulation of gastric mucosal blood circulation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of gastric mucosal blood circulation." [GO_REF:0000058, GOC:TermGenie, PMID:10807413] synonym: "activation of gastric mucosal blood circulation" NARROW [GOC:TermGenie] synonym: "activation of stomach mucosal blood circulation" NARROW [GOC:TermGenie] synonym: "positive regulation of stomach mucosal blood circulation" EXACT [GOC:TermGenie] synonym: "up regulation of gastric mucosal blood circulation" EXACT [GOC:TermGenie] synonym: "up regulation of stomach mucosal blood circulation" EXACT [GOC:TermGenie] synonym: "up-regulation of gastric mucosal blood circulation" EXACT [GOC:TermGenie] synonym: "up-regulation of stomach mucosal blood circulation" EXACT [GOC:TermGenie] synonym: "upregulation of gastric mucosal blood circulation" EXACT [GOC:TermGenie] synonym: "upregulation of stomach mucosal blood circulation" EXACT [GOC:TermGenie] is_a: GO:1903524 ! positive regulation of blood circulation is_a: GO:1904344 ! regulation of gastric mucosal blood circulation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:1990768 ! positively regulates gastric mucosal blood circulation relationship: RO:0002213 GO:1990768 ! positively regulates gastric mucosal blood circulation property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 creation_date: 2015-06-11T21:20:50Z [Term] id: GO:1904347 name: regulation of small intestine smooth muscle contraction namespace: biological_process def: "Any process that modulates the frequency, rate or extent of small intestine smooth muscle contraction." [GO_REF:0000058, GOC:TermGenie, PMID:11991626] is_a: GO:1904304 ! regulation of gastro-intestinal system smooth muscle contraction intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:1990770 ! regulates small intestine smooth muscle contraction relationship: RO:0002211 GO:1990770 ! regulates small intestine smooth muscle contraction creation_date: 2015-06-11T21:37:34Z [Term] id: GO:1904348 name: negative regulation of small intestine smooth muscle contraction namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of small intestine smooth muscle contraction." [GO_REF:0000058, GOC:TermGenie, PMID:11991626] synonym: "down regulation of small intestine smooth muscle contraction" EXACT [GOC:TermGenie] synonym: "down-regulation of small intestine smooth muscle contraction" EXACT [GOC:TermGenie] synonym: "downregulation of small intestine smooth muscle contraction" EXACT [GOC:TermGenie] synonym: "inhibition of small intestine smooth muscle contraction" NARROW [GOC:TermGenie] is_a: GO:1904305 ! negative regulation of gastro-intestinal system smooth muscle contraction is_a: GO:1904347 ! regulation of small intestine smooth muscle contraction intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:1990770 ! negatively regulates small intestine smooth muscle contraction relationship: RO:0002212 GO:1990770 ! negatively regulates small intestine smooth muscle contraction creation_date: 2015-06-11T21:37:40Z [Term] id: GO:1904349 name: positive regulation of small intestine smooth muscle contraction namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of small intestine smooth muscle contraction." [GO_REF:0000058, GOC:TermGenie, PMID:11991626] synonym: "activation of small intestine smooth muscle contraction" NARROW [GOC:TermGenie] synonym: "up regulation of small intestine smooth muscle contraction" EXACT [GOC:TermGenie] synonym: "up-regulation of small intestine smooth muscle contraction" EXACT [GOC:TermGenie] synonym: "upregulation of small intestine smooth muscle contraction" EXACT [GOC:TermGenie] is_a: GO:1904306 ! positive regulation of gastro-intestinal system smooth muscle contraction is_a: GO:1904347 ! regulation of small intestine smooth muscle contraction intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:1990770 ! positively regulates small intestine smooth muscle contraction relationship: RO:0002213 GO:1990770 ! positively regulates small intestine smooth muscle contraction creation_date: 2015-06-11T21:37:46Z [Term] id: GO:1904350 name: regulation of protein catabolic process in the vacuole namespace: biological_process def: "Any process that modulates the frequency, rate or extent of protein catabolic process in the vacuole." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:25635054] synonym: "regulation of vacuolar protein breakdown" RELATED [GOC:TermGenie] synonym: "regulation of vacuolar protein catabolic process" RELATED [GOC:TermGenie] synonym: "regulation of vacuolar protein catabolism" RELATED [GOC:TermGenie] synonym: "regulation of vacuolar protein degradation" RELATED [GOC:TermGenie] is_a: GO:0042176 ! regulation of protein catabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0007039 ! regulates protein catabolic process in the vacuole relationship: RO:0002211 GO:0007039 ! regulates protein catabolic process in the vacuole creation_date: 2015-06-12T09:10:36Z [Term] id: GO:1904351 name: negative regulation of protein catabolic process in the vacuole namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein catabolic process in the vacuole." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:25635054] synonym: "down regulation of protein catabolic process in the vacuole" EXACT [GOC:TermGenie] synonym: "down regulation of vacuolar protein breakdown" RELATED [GOC:TermGenie] synonym: "down regulation of vacuolar protein catabolic process" RELATED [GOC:TermGenie] synonym: "down regulation of vacuolar protein catabolism" RELATED [GOC:TermGenie] synonym: "down regulation of vacuolar protein degradation" RELATED [GOC:TermGenie] synonym: "down-regulation of protein catabolic process in the vacuole" EXACT [GOC:TermGenie] synonym: "down-regulation of vacuolar protein breakdown" RELATED [GOC:TermGenie] synonym: "down-regulation of vacuolar protein catabolic process" RELATED [GOC:TermGenie] synonym: "down-regulation of vacuolar protein catabolism" RELATED [GOC:TermGenie] synonym: "down-regulation of vacuolar protein degradation" RELATED [GOC:TermGenie] synonym: "downregulation of protein catabolic process in the vacuole" EXACT [GOC:TermGenie] synonym: "downregulation of vacuolar protein breakdown" RELATED [GOC:TermGenie] synonym: "downregulation of vacuolar protein catabolic process" RELATED [GOC:TermGenie] synonym: "downregulation of vacuolar protein catabolism" RELATED [GOC:TermGenie] synonym: "downregulation of vacuolar protein degradation" RELATED [GOC:TermGenie] synonym: "inhibition of protein catabolic process in the vacuole" NARROW [GOC:TermGenie] synonym: "inhibition of vacuolar protein breakdown" RELATED [GOC:TermGenie] synonym: "inhibition of vacuolar protein catabolic process" RELATED [GOC:TermGenie] synonym: "inhibition of vacuolar protein catabolism" RELATED [GOC:TermGenie] synonym: "inhibition of vacuolar protein degradation" RELATED [GOC:TermGenie] synonym: "negative regulation of vacuolar protein breakdown" RELATED [GOC:TermGenie] synonym: "negative regulation of vacuolar protein catabolic process" RELATED [GOC:TermGenie] synonym: "negative regulation of vacuolar protein catabolism" RELATED [GOC:TermGenie] synonym: "negative regulation of vacuolar protein degradation" RELATED [GOC:TermGenie] is_a: GO:0042177 ! negative regulation of protein catabolic process is_a: GO:1904350 ! regulation of protein catabolic process in the vacuole intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0007039 ! negatively regulates protein catabolic process in the vacuole relationship: RO:0002212 GO:0007039 ! negatively regulates protein catabolic process in the vacuole creation_date: 2015-06-12T09:10:42Z [Term] id: GO:1904352 name: positive regulation of protein catabolic process in the vacuole namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of protein catabolic process in the vacuole." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:25635054] synonym: "activation of protein catabolic process in the vacuole" NARROW [GOC:TermGenie] synonym: "activation of vacuolar protein breakdown" RELATED [GOC:TermGenie] synonym: "activation of vacuolar protein catabolic process" RELATED [GOC:TermGenie] synonym: "activation of vacuolar protein catabolism" RELATED [GOC:TermGenie] synonym: "activation of vacuolar protein degradation" RELATED [GOC:TermGenie] synonym: "positive regulation of vacuolar protein breakdown" RELATED [GOC:TermGenie] synonym: "positive regulation of vacuolar protein catabolic process" RELATED [GOC:TermGenie] synonym: "positive regulation of vacuolar protein catabolism" RELATED [GOC:TermGenie] synonym: "positive regulation of vacuolar protein degradation" RELATED [GOC:TermGenie] synonym: "up regulation of protein catabolic process in the vacuole" EXACT [GOC:TermGenie] synonym: "up regulation of vacuolar protein breakdown" RELATED [GOC:TermGenie] synonym: "up regulation of vacuolar protein catabolic process" RELATED [GOC:TermGenie] synonym: "up regulation of vacuolar protein catabolism" RELATED [GOC:TermGenie] synonym: "up regulation of vacuolar protein degradation" RELATED [GOC:TermGenie] synonym: "up-regulation of protein catabolic process in the vacuole" EXACT [GOC:TermGenie] synonym: "up-regulation of vacuolar protein breakdown" RELATED [GOC:TermGenie] synonym: "up-regulation of vacuolar protein catabolic process" RELATED [GOC:TermGenie] synonym: "up-regulation of vacuolar protein catabolism" RELATED [GOC:TermGenie] synonym: "up-regulation of vacuolar protein degradation" RELATED [GOC:TermGenie] synonym: "upregulation of protein catabolic process in the vacuole" EXACT [GOC:TermGenie] synonym: "upregulation of vacuolar protein breakdown" RELATED [GOC:TermGenie] synonym: "upregulation of vacuolar protein catabolic process" RELATED [GOC:TermGenie] synonym: "upregulation of vacuolar protein catabolism" RELATED [GOC:TermGenie] synonym: "upregulation of vacuolar protein degradation" RELATED [GOC:TermGenie] is_a: GO:0045732 ! positive regulation of protein catabolic process is_a: GO:1904350 ! regulation of protein catabolic process in the vacuole intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0007039 ! positively regulates protein catabolic process in the vacuole relationship: RO:0002213 GO:0007039 ! positively regulates protein catabolic process in the vacuole creation_date: 2015-06-12T09:10:49Z [Term] id: GO:1904362 name: regulation of calcitonin secretion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of calcitonin secretion." [GO_REF:0000058, GOC:TermGenie, PMID:11278900] is_a: GO:0090276 ! regulation of peptide hormone secretion intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0036161 ! regulates calcitonin secretion relationship: RO:0002211 GO:0036161 ! regulates calcitonin secretion creation_date: 2015-06-15T17:54:52Z [Term] id: GO:1904363 name: negative regulation of calcitonin secretion namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of calcitonin secretion." [GO_REF:0000058, GOC:TermGenie, PMID:11278900] synonym: "down regulation of calcitonin secretion" EXACT [GOC:TermGenie] synonym: "down-regulation of calcitonin secretion" EXACT [GOC:TermGenie] synonym: "downregulation of calcitonin secretion" EXACT [GOC:TermGenie] synonym: "inhibition of calcitonin secretion" NARROW [GOC:TermGenie] is_a: GO:0090278 ! negative regulation of peptide hormone secretion is_a: GO:1904362 ! regulation of calcitonin secretion intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0036161 ! negatively regulates calcitonin secretion relationship: RO:0002212 GO:0036161 ! negatively regulates calcitonin secretion creation_date: 2015-06-15T17:54:58Z [Term] id: GO:1904364 name: positive regulation of calcitonin secretion namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of calcitonin secretion." [GO_REF:0000058, GOC:TermGenie, PMID:11278900] synonym: "activation of calcitonin secretion" NARROW [GOC:TermGenie] synonym: "up regulation of calcitonin secretion" EXACT [GOC:TermGenie] synonym: "up-regulation of calcitonin secretion" EXACT [GOC:TermGenie] synonym: "upregulation of calcitonin secretion" EXACT [GOC:TermGenie] is_a: GO:0090277 ! positive regulation of peptide hormone secretion is_a: GO:1904362 ! regulation of calcitonin secretion intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0036161 ! positively regulates calcitonin secretion relationship: RO:0002213 GO:0036161 ! positively regulates calcitonin secretion creation_date: 2015-06-15T17:55:05Z [Term] id: GO:1904375 name: regulation of protein localization to cell periphery namespace: biological_process def: "Any process that modulates the frequency, rate or extent of protein localization to cell periphery." [GO_REF:0000058, GOC:TermGenie, PMID:18216290] is_a: GO:0032880 ! regulation of protein localization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:1990778 ! regulates protein localization to cell periphery relationship: RO:0002211 GO:1990778 ! regulates protein localization to cell periphery creation_date: 2015-06-22T22:09:25Z [Term] id: GO:1904376 name: negative regulation of protein localization to cell periphery namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to cell periphery." [GO_REF:0000058, GOC:TermGenie, PMID:18216290] synonym: "down regulation of protein localization to cell periphery" EXACT [GOC:TermGenie] synonym: "down-regulation of protein localization to cell periphery" EXACT [GOC:TermGenie] synonym: "downregulation of protein localization to cell periphery" EXACT [GOC:TermGenie] synonym: "inhibition of protein localization to cell periphery" NARROW [GOC:TermGenie] is_a: GO:1903828 ! negative regulation of protein localization is_a: GO:1904375 ! regulation of protein localization to cell periphery intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:1990778 ! negatively regulates protein localization to cell periphery relationship: RO:0002212 GO:1990778 ! negatively regulates protein localization to cell periphery creation_date: 2015-06-22T22:09:32Z [Term] id: GO:1904377 name: positive regulation of protein localization to cell periphery namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of protein localization to cell periphery." [GO_REF:0000058, GOC:TermGenie, PMID:18216290] synonym: "activation of protein localization to cell periphery" NARROW [GOC:TermGenie] synonym: "up regulation of protein localization to cell periphery" EXACT [GOC:TermGenie] synonym: "up-regulation of protein localization to cell periphery" EXACT [GOC:TermGenie] synonym: "upregulation of protein localization to cell periphery" EXACT [GOC:TermGenie] is_a: GO:1903829 ! positive regulation of protein localization is_a: GO:1904375 ! regulation of protein localization to cell periphery intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:1990778 ! positively regulates protein localization to cell periphery relationship: RO:0002213 GO:1990778 ! positively regulates protein localization to cell periphery creation_date: 2015-06-22T22:09:37Z [Term] id: GO:1904389 name: rod bipolar cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires the specialized features of a rod bipolar cell." [GO_REF:0000086, GOC:TermGenie, PMID:16914133] is_a: GO:0060040 ! retinal bipolar neuron differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000751 ! results in acquisition of features of rod bipolar cell relationship: RO:0002315 CL:0000751 ! results in acquisition of features of rod bipolar cell creation_date: 2015-06-23T19:01:11Z [Term] id: GO:1904390 name: cone retinal bipolar cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires the specialized features of a cone retinal bipolar cell." [GO_REF:0000086, GOC:TermGenie, PMID:24123365] synonym: "cone bipolar cell differentiation" EXACT [PMID:14745032] synonym: "retinal cone bipolar cell differentiation" EXACT [] is_a: GO:0060040 ! retinal bipolar neuron differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000752 ! results in acquisition of features of cone retinal bipolar cell relationship: RO:0002315 CL:0000752 ! results in acquisition of features of cone retinal bipolar cell creation_date: 2015-06-23T19:01:16Z [Term] id: GO:1904396 name: regulation of neuromuscular junction development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of neuromuscular junction development." [GO_REF:0000058, GOC:TermGenie, PMID:7722643] synonym: "regulation of neuromuscular junction organization" EXACT [GOC:TermGenie] synonym: "regulation of neuromuscular junction stability" RELATED [GOC:TermGenie] synonym: "regulation of NMJ stability" RELATED [GOC:TermGenie] is_a: GO:0050807 ! regulation of synapse organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0007528 ! regulates neuromuscular junction development relationship: RO:0002211 GO:0007528 ! regulates neuromuscular junction development creation_date: 2015-06-23T19:23:42Z [Term] id: GO:1904397 name: negative regulation of neuromuscular junction development namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of neuromuscular junction development." [GO_REF:0000058, GOC:TermGenie, PMID:7722643] synonym: "down regulation of neuromuscular junction development" EXACT [GOC:TermGenie] synonym: "down regulation of neuromuscular junction organization" EXACT [GOC:TermGenie] synonym: "down regulation of neuromuscular junction stability" RELATED [GOC:TermGenie] synonym: "down regulation of NMJ stability" RELATED [GOC:TermGenie] synonym: "down-regulation of neuromuscular junction development" EXACT [GOC:TermGenie] synonym: "down-regulation of neuromuscular junction organization" EXACT [GOC:TermGenie] synonym: "down-regulation of neuromuscular junction stability" RELATED [GOC:TermGenie] synonym: "down-regulation of NMJ stability" RELATED [GOC:TermGenie] synonym: "downregulation of neuromuscular junction development" EXACT [GOC:TermGenie] synonym: "downregulation of neuromuscular junction organization" EXACT [GOC:TermGenie] synonym: "downregulation of neuromuscular junction stability" RELATED [GOC:TermGenie] synonym: "downregulation of NMJ stability" RELATED [GOC:TermGenie] synonym: "inhibition of neuromuscular junction development" NARROW [GOC:TermGenie] synonym: "inhibition of neuromuscular junction organization" NARROW [GOC:TermGenie] synonym: "inhibition of neuromuscular junction stability" RELATED [GOC:TermGenie] synonym: "inhibition of NMJ stability" RELATED [GOC:TermGenie] synonym: "negative regulation of neuromuscular junction organization" EXACT [GOC:TermGenie] synonym: "negative regulation of neuromuscular junction stability" RELATED [GOC:TermGenie] synonym: "negative regulation of NMJ stability" RELATED [GOC:TermGenie] is_a: GO:1904396 ! regulation of neuromuscular junction development is_a: GO:1905809 ! negative regulation of synapse organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0007528 ! negatively regulates neuromuscular junction development relationship: RO:0002212 GO:0007528 ! negatively regulates neuromuscular junction development creation_date: 2015-06-23T19:23:48Z [Term] id: GO:1904398 name: positive regulation of neuromuscular junction development namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of neuromuscular junction development." [GO_REF:0000058, GOC:TermGenie, PMID:7722643] synonym: "activation of neuromuscular junction development" NARROW [GOC:TermGenie] synonym: "activation of neuromuscular junction organization" NARROW [GOC:TermGenie] synonym: "activation of neuromuscular junction stability" RELATED [GOC:TermGenie] synonym: "activation of NMJ stability" RELATED [GOC:TermGenie] synonym: "positive regulation of neuromuscular junction organization" EXACT [GOC:TermGenie] synonym: "positive regulation of neuromuscular junction stability" RELATED [GOC:TermGenie] synonym: "positive regulation of NMJ stability" RELATED [GOC:TermGenie] synonym: "up regulation of neuromuscular junction development" EXACT [GOC:TermGenie] synonym: "up regulation of neuromuscular junction organization" EXACT [GOC:TermGenie] synonym: "up regulation of neuromuscular junction stability" RELATED [GOC:TermGenie] synonym: "up regulation of NMJ stability" RELATED [GOC:TermGenie] synonym: "up-regulation of neuromuscular junction development" EXACT [GOC:TermGenie] synonym: "up-regulation of neuromuscular junction organization" EXACT [GOC:TermGenie] synonym: "up-regulation of neuromuscular junction stability" RELATED [GOC:TermGenie] synonym: "up-regulation of NMJ stability" RELATED [GOC:TermGenie] synonym: "upregulation of neuromuscular junction development" EXACT [GOC:TermGenie] synonym: "upregulation of neuromuscular junction organization" EXACT [GOC:TermGenie] synonym: "upregulation of neuromuscular junction stability" RELATED [GOC:TermGenie] synonym: "upregulation of NMJ stability" RELATED [GOC:TermGenie] is_a: GO:0051130 ! positive regulation of cellular component organization is_a: GO:1904396 ! regulation of neuromuscular junction development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0007528 ! positively regulates neuromuscular junction development relationship: RO:0002213 GO:0007528 ! positively regulates neuromuscular junction development creation_date: 2015-06-23T19:23:54Z [Term] id: GO:1904408 name: melatonin binding namespace: molecular_function def: "Binding to melatonin." [GO_REF:0000067, GOC:mr, GOC:TermGenie, PMID:10379923] is_a: GO:0033218 ! amide binding intersection_of: GO:0005488 ! binding intersection_of: RO:0004009 CHEBI:16796 ! has primary input relationship: RO:0004009 CHEBI:16796 ! has primary input creation_date: 2015-06-25T19:19:53Z [Term] id: GO:1904409 name: regulation of secretory granule organization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of secretory granule organization." [GO_REF:0000058, GOC:TermGenie, PMID:15039777] synonym: "regulation of secretory granule organisation" EXACT [GOC:TermGenie] synonym: "regulation of secretory granule organization and biogenesis" RELATED [GOC:TermGenie] is_a: GO:0033043 ! regulation of organelle organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0033363 ! regulates secretory granule organization relationship: RO:0002211 GO:0033363 ! regulates secretory granule organization creation_date: 2015-06-25T19:40:42Z [Term] id: GO:1904410 name: negative regulation of secretory granule organization namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of secretory granule organization." [GO_REF:0000058, GOC:TermGenie, PMID:15039777] synonym: "down regulation of secretory granule organisation" EXACT [GOC:TermGenie] synonym: "down regulation of secretory granule organization" EXACT [GOC:TermGenie] synonym: "down regulation of secretory granule organization and biogenesis" RELATED [GOC:TermGenie] synonym: "down-regulation of secretory granule organisation" EXACT [GOC:TermGenie] synonym: "down-regulation of secretory granule organization" EXACT [GOC:TermGenie] synonym: "down-regulation of secretory granule organization and biogenesis" RELATED [GOC:TermGenie] synonym: "downregulation of secretory granule organisation" EXACT [GOC:TermGenie] synonym: "downregulation of secretory granule organization" EXACT [GOC:TermGenie] synonym: "downregulation of secretory granule organization and biogenesis" RELATED [GOC:TermGenie] synonym: "inhibition of secretory granule organisation" NARROW [GOC:TermGenie] synonym: "inhibition of secretory granule organization" NARROW [GOC:TermGenie] synonym: "inhibition of secretory granule organization and biogenesis" RELATED [GOC:TermGenie] synonym: "negative regulation of secretory granule organisation" EXACT [GOC:TermGenie] synonym: "negative regulation of secretory granule organization and biogenesis" RELATED [GOC:TermGenie] is_a: GO:0010639 ! negative regulation of organelle organization is_a: GO:1904409 ! regulation of secretory granule organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0033363 ! negatively regulates secretory granule organization relationship: RO:0002212 GO:0033363 ! negatively regulates secretory granule organization creation_date: 2015-06-25T19:40:49Z [Term] id: GO:1904411 name: positive regulation of secretory granule organization namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of secretory granule organization." [GO_REF:0000058, GOC:TermGenie, PMID:15039777] synonym: "activation of secretory granule organisation" NARROW [GOC:TermGenie] synonym: "activation of secretory granule organization" NARROW [GOC:TermGenie] synonym: "activation of secretory granule organization and biogenesis" RELATED [GOC:TermGenie] synonym: "positive regulation of secretory granule organisation" EXACT [GOC:TermGenie] synonym: "positive regulation of secretory granule organization and biogenesis" RELATED [GOC:TermGenie] synonym: "up regulation of secretory granule organisation" EXACT [GOC:TermGenie] synonym: "up regulation of secretory granule organization" EXACT [GOC:TermGenie] synonym: "up regulation of secretory granule organization and biogenesis" RELATED [GOC:TermGenie] synonym: "up-regulation of secretory granule organisation" EXACT [GOC:TermGenie] synonym: "up-regulation of secretory granule organization" EXACT [GOC:TermGenie] synonym: "up-regulation of secretory granule organization and biogenesis" RELATED [GOC:TermGenie] synonym: "upregulation of secretory granule organisation" EXACT [GOC:TermGenie] synonym: "upregulation of secretory granule organization" EXACT [GOC:TermGenie] synonym: "upregulation of secretory granule organization and biogenesis" RELATED [GOC:TermGenie] is_a: GO:0010638 ! positive regulation of organelle organization is_a: GO:1904409 ! regulation of secretory granule organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0033363 ! positively regulates secretory granule organization relationship: RO:0002213 GO:0033363 ! positively regulates secretory granule organization creation_date: 2015-06-25T19:40:55Z [Term] id: GO:1904412 name: regulation of cardiac ventricle development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cardiac ventricle development." [GO_REF:0000058, GOC:TermGenie, PMID:19590510] is_a: GO:0050793 ! regulation of developmental process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0003231 ! regulates cardiac ventricle development relationship: RO:0002211 GO:0003231 ! regulates cardiac ventricle development creation_date: 2015-06-25T19:52:15Z [Term] id: GO:1904413 name: negative regulation of cardiac ventricle development namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of cardiac ventricle development." [GO_REF:0000058, GOC:TermGenie, PMID:19590510] synonym: "down regulation of cardiac ventricle development" EXACT [GOC:TermGenie] synonym: "down-regulation of cardiac ventricle development" EXACT [GOC:TermGenie] synonym: "downregulation of cardiac ventricle development" EXACT [GOC:TermGenie] synonym: "inhibition of cardiac ventricle development" NARROW [GOC:TermGenie] is_a: GO:0051093 ! negative regulation of developmental process is_a: GO:0051241 ! negative regulation of multicellular organismal process is_a: GO:1904412 ! regulation of cardiac ventricle development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0003231 ! negatively regulates cardiac ventricle development relationship: RO:0002212 GO:0003231 ! negatively regulates cardiac ventricle development creation_date: 2015-06-25T19:52:21Z [Term] id: GO:1904414 name: positive regulation of cardiac ventricle development namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cardiac ventricle development." [GO_REF:0000058, GOC:TermGenie, PMID:19590510] synonym: "activation of cardiac ventricle development" NARROW [GOC:TermGenie] synonym: "up regulation of cardiac ventricle development" EXACT [GOC:TermGenie] synonym: "up-regulation of cardiac ventricle development" EXACT [GOC:TermGenie] synonym: "upregulation of cardiac ventricle development" EXACT [GOC:TermGenie] is_a: GO:0051094 ! positive regulation of developmental process is_a: GO:0051240 ! positive regulation of multicellular organismal process is_a: GO:1904412 ! regulation of cardiac ventricle development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0003231 ! positively regulates cardiac ventricle development relationship: RO:0002213 GO:0003231 ! positively regulates cardiac ventricle development creation_date: 2015-06-25T19:52:27Z [Term] id: GO:1904427 name: positive regulation of calcium ion transmembrane transport namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of calcium ion transmembrane transport." [GO_REF:0000058, GOC:TermGenie, PMID:22910094] synonym: "activation of calcium ion membrane transport" NARROW [GOC:TermGenie] synonym: "activation of calcium ion transmembrane transport" NARROW [GOC:TermGenie] synonym: "activation of transmembrane calcium transport" NARROW [GOC:TermGenie] synonym: "positive regulation of calcium ion membrane transport" EXACT [GOC:TermGenie] synonym: "positive regulation of transmembrane calcium transport" EXACT [GOC:TermGenie] synonym: "up regulation of calcium ion membrane transport" EXACT [GOC:TermGenie] synonym: "up regulation of calcium ion transmembrane transport" EXACT [GOC:TermGenie] synonym: "up regulation of transmembrane calcium transport" EXACT [GOC:TermGenie] synonym: "up-regulation of calcium ion membrane transport" EXACT [GOC:TermGenie] synonym: "up-regulation of calcium ion transmembrane transport" EXACT [GOC:TermGenie] synonym: "up-regulation of transmembrane calcium transport" EXACT [GOC:TermGenie] synonym: "upregulation of calcium ion membrane transport" EXACT [GOC:TermGenie] synonym: "upregulation of calcium ion transmembrane transport" EXACT [GOC:TermGenie] synonym: "upregulation of transmembrane calcium transport" EXACT [GOC:TermGenie] is_a: GO:0051928 ! positive regulation of calcium ion transport is_a: GO:1903169 ! regulation of calcium ion transmembrane transport is_a: GO:1904064 ! positive regulation of cation transmembrane transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0070588 ! positively regulates calcium ion transmembrane transport relationship: RO:0002213 GO:0070588 ! positively regulates calcium ion transmembrane transport creation_date: 2015-07-02T20:44:25Z [Term] id: GO:1904438 name: regulation of iron ion import across plasma membrane namespace: biological_process def: "Any process that modulates the frequency, rate or extent of iron ions import across plasma membrane." [GO_REF:0000058, GOC:BHF, GOC:kom, GOC:TermGenie, PMID:18353247] synonym: "regulation of ferrous ion import into cell" RELATED [GOC:TermGenie] synonym: "regulation of ferrous iron import across plasma membrane" RELATED [] synonym: "regulation of ferrous iron import into cell" RELATED [] is_a: GO:0034759 ! regulation of iron ion transmembrane transport is_a: GO:0060341 ! regulation of cellular localization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0098711 ! regulates iron ion import across plasma membrane relationship: RO:0002211 GO:0098711 ! regulates iron ion import across plasma membrane creation_date: 2015-03-04T14:37:36Z [Term] id: GO:1904439 name: negative regulation of iron ion import across plasma membrane namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of iron ions import across plasma membrane." [GO_REF:0000058, GOC:BHF, GOC:kom, GOC:TermGenie, PMID:18353247] synonym: "down regulation of ferrous ion import into cell" RELATED [GOC:TermGenie] synonym: "down regulation of ferrous iron import across plasma membrane" RELATED [GOC:TermGenie] synonym: "down-regulation of ferrous ion import into cell" RELATED [GOC:TermGenie] synonym: "down-regulation of ferrous iron import across plasma membrane" RELATED [GOC:TermGenie] synonym: "downregulation of ferrous ion import into cell" RELATED [GOC:TermGenie] synonym: "downregulation of ferrous iron import across plasma membrane" RELATED [GOC:TermGenie] synonym: "inhibition of ferrous ion import into cell" NARROW [GOC:TermGenie] synonym: "inhibition of ferrous iron import across plasma membrane" NARROW [GOC:TermGenie] synonym: "negative regulation of ferrous ion import into cell" RELATED [GOC:TermGenie] synonym: "negative regulation of ferrous iron import across plasma membrane" RELATED [] synonym: "negative regulation of ferrous iron import into cell" RELATED [] is_a: GO:0034760 ! negative regulation of iron ion transmembrane transport is_a: GO:1904438 ! regulation of iron ion import across plasma membrane intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0098711 ! negatively regulates iron ion import across plasma membrane relationship: RO:0002212 GO:0098711 ! negatively regulates iron ion import across plasma membrane creation_date: 2015-07-06T13:49:58Z [Term] id: GO:1904440 name: positive regulation of iron ion import across plasma membrane namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of iron ions import across plasma membrane." [GO_REF:0000058, GOC:BHF, GOC:kom, GOC:TermGenie, PMID:18353247] synonym: "activation of ferrous ion import into cell" NARROW [GOC:TermGenie] synonym: "activation of ferrous iron import across plasma membrane" NARROW [GOC:TermGenie] synonym: "positive regulation of ferrous ion import into cell" RELATED [GOC:TermGenie] synonym: "positive regulation of ferrous iron import across plasma membrane" RELATED [] synonym: "positive regulation of ferrous iron import into cell" RELATED [] synonym: "up regulation of ferrous ion import into cell" RELATED [GOC:TermGenie] synonym: "up regulation of ferrous iron import across plasma membrane" RELATED [GOC:TermGenie] synonym: "up-regulation of ferrous ion import into cell" RELATED [GOC:TermGenie] synonym: "up-regulation of ferrous iron import across plasma membrane" RELATED [GOC:TermGenie] synonym: "upregulation of ferrous ion import into cell" RELATED [GOC:TermGenie] synonym: "upregulation of ferrous iron import across plasma membrane" RELATED [GOC:TermGenie] is_a: GO:0034761 ! positive regulation of iron ion transmembrane transport is_a: GO:1904438 ! regulation of iron ion import across plasma membrane intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0098711 ! positively regulates iron ion import across plasma membrane relationship: RO:0002213 GO:0098711 ! positively regulates iron ion import across plasma membrane creation_date: 2015-07-06T13:50:04Z [Term] id: GO:1904456 name: negative regulation of neuronal action potential namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of neuronal action potential." [GO_REF:0000058, GOC:TermGenie, PMID:25126967] synonym: "down regulation of generation of action potential" RELATED [GOC:TermGenie] synonym: "down regulation of neuronal action potential" EXACT [GOC:TermGenie] synonym: "down-regulation of generation of action potential" RELATED [GOC:TermGenie] synonym: "down-regulation of neuronal action potential" EXACT [GOC:TermGenie] synonym: "downregulation of generation of action potential" RELATED [GOC:TermGenie] synonym: "downregulation of neuronal action potential" EXACT [GOC:TermGenie] synonym: "inhibition of generation of action potential" RELATED [GOC:TermGenie] synonym: "inhibition of neuronal action potential" NARROW [GOC:TermGenie] synonym: "negative regulation of generation of action potential" RELATED [GOC:TermGenie] is_a: GO:0045759 ! negative regulation of action potential is_a: GO:0051970 ! negative regulation of transmission of nerve impulse is_a: GO:0098908 ! regulation of neuronal action potential intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0019228 ! negatively regulates neuronal action potential relationship: RO:0002212 GO:0019228 ! negatively regulates neuronal action potential creation_date: 2015-07-09T18:02:40Z [Term] id: GO:1904457 name: positive regulation of neuronal action potential namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of neuronal action potential." [GO_REF:0000058, GOC:TermGenie, PMID:25126967] synonym: "activation of generation of action potential" RELATED [GOC:TermGenie] synonym: "activation of neuronal action potential" NARROW [GOC:TermGenie] synonym: "positive regulation of generation of action potential" RELATED [GOC:TermGenie] synonym: "up regulation of generation of action potential" RELATED [GOC:TermGenie] synonym: "up regulation of neuronal action potential" EXACT [GOC:TermGenie] synonym: "up-regulation of generation of action potential" RELATED [GOC:TermGenie] synonym: "up-regulation of neuronal action potential" EXACT [GOC:TermGenie] synonym: "upregulation of generation of action potential" RELATED [GOC:TermGenie] synonym: "upregulation of neuronal action potential" EXACT [GOC:TermGenie] is_a: GO:0045760 ! positive regulation of action potential is_a: GO:0051971 ! positive regulation of transmission of nerve impulse is_a: GO:0098908 ! regulation of neuronal action potential intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0019228 ! positively regulates neuronal action potential relationship: RO:0002213 GO:0019228 ! positively regulates neuronal action potential creation_date: 2015-07-09T18:02:46Z [Term] id: GO:1904484 name: cloacal gland development namespace: biological_process def: "The process whose specific outcome is the progression of a cloacal gland over time, from its formation to the mature structure." [GO_REF:0000094, GOC:mr, GOC:TermGenie, PMID:18805421] is_a: GO:0048732 ! gland development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0012478 ! results in development of cloacal gland relationship: RO:0002296 UBERON:0012478 ! results in development of cloacal gland creation_date: 2015-07-15T22:14:39Z [Term] id: GO:1904491 name: protein localization to ciliary transition zone namespace: biological_process def: "A process in which a protein is transported to, or maintained in, a location within a ciliary transition zone." [GO_REF:0000087, GOC:kmv, GOC:TermGenie, PMID:21422230] synonym: "protein localisation in ciliary transition zone" EXACT [GOC:TermGenie] synonym: "protein localisation to ciliary transition zone" EXACT [GOC:TermGenie] synonym: "protein localization in ciliary transition zone" EXACT [GOC:TermGenie] is_a: GO:0061512 ! protein localization to cilium intersection_of: GO:0008104 ! intracellular protein localization intersection_of: RO:0002339 GO:0035869 ! has target end location ciliary transition zone relationship: RO:0002339 GO:0035869 ! has target end location ciliary transition zone property_value: RO:0002161 NCBITaxon:3176 property_value: RO:0002161 NCBITaxon:3378 property_value: RO:0002161 NCBITaxon:3398 property_value: RO:0002161 NCBITaxon:4890 property_value: RO:0002161 NCBITaxon:5782 creation_date: 2015-07-17T20:43:21Z [Term] id: GO:1904516 name: myofibroblast cell apoptotic process namespace: biological_process def: "Any apoptotic process in a myofibroblast cell." [GO_REF:0000085, GOC:TermGenie, PMID:23026405] synonym: "MFB apoptosis" NARROW [GOC:TermGenie] synonym: "MFB apoptotic process" EXACT [GOC:TermGenie] synonym: "myofibroblast cell apoptosis" NARROW [GOC:TermGenie] is_a: GO:0006915 ! apoptotic process intersection_of: GO:0006915 ! apoptotic process intersection_of: BFO:0000066 CL:0000186 ! occurs in myofibroblast cell relationship: BFO:0000066 CL:0000186 ! occurs in myofibroblast cell property_value: RO:0002161 NCBITaxon:4896 creation_date: 2015-07-28T18:29:08Z [Term] id: GO:1904520 name: regulation of myofibroblast cell apoptotic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of myofibroblast cell apoptotic process." [GO_REF:0000058, GOC:TermGenie, PMID:26119034] synonym: "regulation of MFB apoptosis" NARROW [GOC:TermGenie] synonym: "regulation of MFB apoptotic process" EXACT [GOC:TermGenie] synonym: "regulation of myofibroblast cell apoptosis" NARROW [GOC:TermGenie] is_a: GO:0042981 ! regulation of apoptotic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:1904516 ! regulates myofibroblast cell apoptotic process relationship: RO:0002211 GO:1904516 ! regulates myofibroblast cell apoptotic process property_value: RO:0002161 NCBITaxon:4896 creation_date: 2015-07-29T15:52:14Z [Term] id: GO:1904521 name: negative regulation of myofibroblast cell apoptotic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of myofibroblast cell apoptotic process." [GO_REF:0000058, GOC:TermGenie, PMID:26119034] synonym: "down regulation of MFB apoptosis" NARROW [GOC:TermGenie] synonym: "down regulation of MFB apoptotic process" EXACT [GOC:TermGenie] synonym: "down regulation of myofibroblast cell apoptosis" NARROW [GOC:TermGenie] synonym: "down regulation of myofibroblast cell apoptotic process" EXACT [GOC:TermGenie] synonym: "down-regulation of MFB apoptosis" NARROW [GOC:TermGenie] synonym: "down-regulation of MFB apoptotic process" EXACT [GOC:TermGenie] synonym: "down-regulation of myofibroblast cell apoptosis" NARROW [GOC:TermGenie] synonym: "down-regulation of myofibroblast cell apoptotic process" EXACT [GOC:TermGenie] synonym: "downregulation of MFB apoptosis" NARROW [GOC:TermGenie] synonym: "downregulation of MFB apoptotic process" EXACT [GOC:TermGenie] synonym: "downregulation of myofibroblast cell apoptosis" NARROW [GOC:TermGenie] synonym: "downregulation of myofibroblast cell apoptotic process" EXACT [GOC:TermGenie] synonym: "inhibition of MFB apoptosis" NARROW [GOC:TermGenie] synonym: "inhibition of MFB apoptotic process" NARROW [GOC:TermGenie] synonym: "inhibition of myofibroblast cell apoptosis" NARROW [GOC:TermGenie] synonym: "inhibition of myofibroblast cell apoptotic process" NARROW [GOC:TermGenie] synonym: "negative regulation of MFB apoptosis" NARROW [GOC:TermGenie] synonym: "negative regulation of MFB apoptotic process" EXACT [GOC:TermGenie] synonym: "negative regulation of myofibroblast cell apoptosis" NARROW [GOC:TermGenie] is_a: GO:0043066 ! negative regulation of apoptotic process is_a: GO:1904520 ! regulation of myofibroblast cell apoptotic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:1904516 ! negatively regulates myofibroblast cell apoptotic process relationship: RO:0002212 GO:1904516 ! negatively regulates myofibroblast cell apoptotic process property_value: RO:0002161 NCBITaxon:4896 creation_date: 2015-07-29T15:52:20Z [Term] id: GO:1904522 name: positive regulation of myofibroblast cell apoptotic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of myofibroblast cell apoptotic process." [GO_REF:0000058, GOC:TermGenie, PMID:26119034] synonym: "activation of MFB apoptosis" NARROW [GOC:TermGenie] synonym: "activation of MFB apoptotic process" NARROW [GOC:TermGenie] synonym: "activation of myofibroblast cell apoptosis" NARROW [GOC:TermGenie] synonym: "activation of myofibroblast cell apoptotic process" NARROW [GOC:TermGenie] synonym: "positive regulation of MFB apoptosis" NARROW [GOC:TermGenie] synonym: "positive regulation of MFB apoptotic process" EXACT [GOC:TermGenie] synonym: "positive regulation of myofibroblast cell apoptosis" NARROW [GOC:TermGenie] synonym: "up regulation of MFB apoptosis" NARROW [GOC:TermGenie] synonym: "up regulation of MFB apoptotic process" EXACT [GOC:TermGenie] synonym: "up regulation of myofibroblast cell apoptosis" NARROW [GOC:TermGenie] synonym: "up regulation of myofibroblast cell apoptotic process" EXACT [GOC:TermGenie] synonym: "up-regulation of MFB apoptosis" NARROW [GOC:TermGenie] synonym: "up-regulation of MFB apoptotic process" EXACT [GOC:TermGenie] synonym: "up-regulation of myofibroblast cell apoptosis" NARROW [GOC:TermGenie] synonym: "up-regulation of myofibroblast cell apoptotic process" EXACT [GOC:TermGenie] synonym: "upregulation of MFB apoptosis" NARROW [GOC:TermGenie] synonym: "upregulation of MFB apoptotic process" EXACT [GOC:TermGenie] synonym: "upregulation of myofibroblast cell apoptosis" NARROW [GOC:TermGenie] synonym: "upregulation of myofibroblast cell apoptotic process" EXACT [GOC:TermGenie] is_a: GO:0043065 ! positive regulation of apoptotic process is_a: GO:1904520 ! regulation of myofibroblast cell apoptotic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:1904516 ! positively regulates myofibroblast cell apoptotic process relationship: RO:0002213 GO:1904516 ! positively regulates myofibroblast cell apoptotic process property_value: RO:0002161 NCBITaxon:4896 creation_date: 2015-07-29T15:52:26Z [Term] id: GO:1904587 name: response to glycoprotein namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glycoprotein stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:14597422] synonym: "response to glycoproteins" EXACT [] is_a: GO:1901698 ! response to nitrogen compound is_a: GO:1901700 ! response to oxygen-containing compound intersection_of: GO:0050896 ! response to stimulus intersection_of: RO:0004009 CHEBI:17089 ! has primary input relationship: RO:0004009 CHEBI:17089 ! has primary input creation_date: 2015-08-20T16:46:24Z [Term] id: GO:1904588 name: cellular response to glycoprotein namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glycoprotein stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:14597422] synonym: "cellular response to glycoproteins" EXACT [] is_a: GO:1901699 ! cellular response to nitrogen compound is_a: GO:1901701 ! cellular response to oxygen-containing compound is_a: GO:1904587 ! response to glycoprotein intersection_of: GO:0070887 ! cellular response to chemical stimulus intersection_of: RO:0004009 CHEBI:17089 ! has primary input creation_date: 2015-08-20T16:46:30Z [Term] id: GO:1904602 name: serotonin-activated cation-selective channel complex namespace: cellular_component def: "A protein complex which is capable of serotonin-activated cation-selective channel activity. Mainly found in pre- and postsynaptic membranes of the brain and gastrointestinal tract. Depending on its location it transports Ca2+, Mg2+, Na+ or K+. It is always a pentamer, containing at least the 5HT3A subunit forming 5HT3A homopentamers or 5HT3A/B heteropentamers. In human, 5HT3A/C, A/D and A/E heteropentamers also exist." [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:16116092] comment: An example of this is HTR3A in human (P46098) in PMID:16116092 (inferred from direct assay). synonym: "5-HT-3 receptor complex" EXACT [] synonym: "5-HT3 receptor complex" EXACT [] synonym: "5-hydroxytryptamine receptor 3 complex" EXACT [] synonym: "5HT3 receptor complex" EXACT [] synonym: "serotonin receptor complex" BROAD [] is_a: GO:0034703 ! cation channel complex is_a: GO:0098665 ! serotonin receptor complex is_a: GO:0098878 ! neurotransmitter receptor complex intersection_of: GO:0032991 ! protein-containing complex intersection_of: RO:0002215 GO:0022850 ! capable of serotonin-gated monoatomic cation channel activity relationship: RO:0002215 GO:0022850 ! capable of serotonin-gated monoatomic cation channel activity relationship: RO:0002216 GO:0007210 ! capable of part of serotonin receptor signaling pathway property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/12942" xsd:anyURI creation_date: 2015-08-26T13:19:49Z [Term] id: GO:1904606 name: fat cell apoptotic process namespace: biological_process def: "Any apoptotic process in a fat cell." [GO_REF:0000085, GOC:TermGenie, PMID:17024416] synonym: "adipocyte apoptosis" NARROW [GOC:TermGenie] synonym: "adipocyte apoptotic process" EXACT [GOC:TermGenie] synonym: "adipose cell apoptosis" NARROW [GOC:TermGenie] synonym: "adipose cell apoptotic process" EXACT [GOC:TermGenie] synonym: "fat cell apoptosis" NARROW [GOC:TermGenie] is_a: GO:0006915 ! apoptotic process intersection_of: GO:0006915 ! apoptotic process intersection_of: BFO:0000066 CL:0000136 ! occurs in adipocyte relationship: BFO:0000066 CL:0000136 ! occurs in adipocyte property_value: RO:0002161 NCBITaxon:4896 creation_date: 2015-08-27T18:13:06Z [Term] id: GO:1904624 name: regulation of glycine secretion, neurotransmission namespace: biological_process def: "Any process that modulates the frequency, rate or extent of glycine secretion, neurotransmission." [GO_REF:0000058, GOC:TermGenie, PMID:22988142] is_a: GO:0032890 ! regulation of organic acid transport is_a: GO:0046928 ! regulation of neurotransmitter secretion is_a: GO:0051955 ! regulation of amino acid transport is_a: GO:0060092 ! regulation of synaptic transmission, glycinergic intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0061537 ! regulates glycine secretion, neurotransmission relationship: RO:0002211 GO:0061537 ! regulates glycine secretion, neurotransmission creation_date: 2015-08-27T20:03:38Z [Term] id: GO:1904625 name: negative regulation of glycine secretion, neurotransmission namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of glycine secretion, neurotransmission." [GO_REF:0000058, GOC:TermGenie, PMID:22988142] synonym: "down regulation of glycine secretion, neurotransmission" EXACT [GOC:TermGenie] synonym: "down-regulation of glycine secretion, neurotransmission" EXACT [GOC:TermGenie] synonym: "downregulation of glycine secretion, neurotransmission" EXACT [GOC:TermGenie] synonym: "inhibition of glycine secretion, neurotransmission" NARROW [GOC:TermGenie] is_a: GO:0032891 ! negative regulation of organic acid transport is_a: GO:0046929 ! negative regulation of neurotransmitter secretion is_a: GO:0051956 ! negative regulation of amino acid transport is_a: GO:0060093 ! negative regulation of synaptic transmission, glycinergic is_a: GO:1904624 ! regulation of glycine secretion, neurotransmission intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0061537 ! negatively regulates glycine secretion, neurotransmission relationship: RO:0002212 GO:0061537 ! negatively regulates glycine secretion, neurotransmission creation_date: 2015-08-27T20:03:44Z [Term] id: GO:1904626 name: positive regulation of glycine secretion, neurotransmission namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of glycine secretion, neurotransmission." [GO_REF:0000058, GOC:TermGenie, PMID:22988142] synonym: "activation of glycine secretion, neurotransmission" NARROW [GOC:TermGenie] synonym: "up regulation of glycine secretion, neurotransmission" EXACT [GOC:TermGenie] synonym: "up-regulation of glycine secretion, neurotransmission" EXACT [GOC:TermGenie] synonym: "upregulation of glycine secretion, neurotransmission" EXACT [GOC:TermGenie] is_a: GO:0001956 ! positive regulation of neurotransmitter secretion is_a: GO:0032892 ! positive regulation of organic acid transport is_a: GO:0051957 ! positive regulation of amino acid transport is_a: GO:0060094 ! positive regulation of synaptic transmission, glycinergic is_a: GO:1904624 ! regulation of glycine secretion, neurotransmission intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0061537 ! positively regulates glycine secretion, neurotransmission relationship: RO:0002213 GO:0061537 ! positively regulates glycine secretion, neurotransmission creation_date: 2015-08-27T20:03:49Z [Term] id: GO:1904633 name: regulation of podocyte apoptotic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of glomerular visceral epithelial cell apoptotic process." [GO_REF:0000058, GOC:TermGenie, PMID:23692924] synonym: "regulation of glomerular podocyte apoptosis" NARROW [GOC:TermGenie] synonym: "regulation of glomerular podocyte apoptotic process" EXACT [GOC:TermGenie] synonym: "regulation of glomerular visceral epithelial cell apoptosis" NARROW [GOC:TermGenie] synonym: "regulation of glomerular visceral epithelial cell apoptotic process" EXACT [] synonym: "regulation of podocyte apoptosis" NARROW [GOC:TermGenie] is_a: GO:1904035 ! regulation of epithelial cell apoptotic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:1903210 ! regulates podocyte apoptotic process relationship: RO:0002211 GO:1903210 ! regulates podocyte apoptotic process property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/23000" xsd:anyURI property_value: RO:0002161 NCBITaxon:4751 creation_date: 2015-08-28T14:14:44Z [Term] id: GO:1904634 name: negative regulation of podocyte apoptotic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of glomerular visceral epithelial cell apoptotic process." [GO_REF:0000058, GOC:TermGenie, PMID:23692924] synonym: "down regulation of glomerular podocyte apoptosis" NARROW [GOC:TermGenie] synonym: "down regulation of glomerular podocyte apoptotic process" EXACT [GOC:TermGenie] synonym: "down regulation of glomerular visceral epithelial cell apoptosis" NARROW [GOC:TermGenie] synonym: "down regulation of glomerular visceral epithelial cell apoptotic process" EXACT [GOC:TermGenie] synonym: "down regulation of podocyte apoptosis" NARROW [GOC:TermGenie] synonym: "down regulation of podocyte apoptotic process" EXACT [GOC:TermGenie] synonym: "down-regulation of glomerular podocyte apoptosis" NARROW [GOC:TermGenie] synonym: "down-regulation of glomerular podocyte apoptotic process" EXACT [GOC:TermGenie] synonym: "down-regulation of glomerular visceral epithelial cell apoptosis" NARROW [GOC:TermGenie] synonym: "down-regulation of glomerular visceral epithelial cell apoptotic process" EXACT [GOC:TermGenie] synonym: "down-regulation of podocyte apoptosis" NARROW [GOC:TermGenie] synonym: "down-regulation of podocyte apoptotic process" EXACT [GOC:TermGenie] synonym: "downregulation of glomerular podocyte apoptosis" NARROW [GOC:TermGenie] synonym: "downregulation of glomerular podocyte apoptotic process" EXACT [GOC:TermGenie] synonym: "downregulation of glomerular visceral epithelial cell apoptosis" NARROW [GOC:TermGenie] synonym: "downregulation of glomerular visceral epithelial cell apoptotic process" EXACT [GOC:TermGenie] synonym: "downregulation of podocyte apoptosis" NARROW [GOC:TermGenie] synonym: "downregulation of podocyte apoptotic process" EXACT [GOC:TermGenie] synonym: "inhibition of glomerular podocyte apoptosis" NARROW [GOC:TermGenie] synonym: "inhibition of glomerular podocyte apoptotic process" NARROW [GOC:TermGenie] synonym: "inhibition of glomerular visceral epithelial cell apoptosis" NARROW [GOC:TermGenie] synonym: "inhibition of glomerular visceral epithelial cell apoptotic process" NARROW [GOC:TermGenie] synonym: "inhibition of podocyte apoptosis" NARROW [GOC:TermGenie] synonym: "inhibition of podocyte apoptotic process" NARROW [GOC:TermGenie] synonym: "negative regulation of glomerular podocyte apoptosis" NARROW [GOC:TermGenie] synonym: "negative regulation of glomerular podocyte apoptotic process" EXACT [GOC:TermGenie] synonym: "negative regulation of glomerular visceral epithelial cell apoptosis" NARROW [GOC:TermGenie] synonym: "negative regulation of glomerular visceral epithelial cell apoptotic process" EXACT [] synonym: "negative regulation of podocyte apoptosis" EXACT [GOC:TermGenie] is_a: GO:1904036 ! negative regulation of epithelial cell apoptotic process is_a: GO:1904633 ! regulation of podocyte apoptotic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:1903210 ! negatively regulates podocyte apoptotic process relationship: RO:0002212 GO:1903210 ! negatively regulates podocyte apoptotic process property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/23000" xsd:anyURI property_value: RO:0002161 NCBITaxon:4751 creation_date: 2015-08-28T14:14:50Z [Term] id: GO:1904635 name: positive regulation of podocyte apoptotic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of glomerular visceral epithelial cell apoptotic process." [GO_REF:0000058, GOC:TermGenie, PMID:23692924] synonym: "activation of glomerular podocyte apoptosis" NARROW [GOC:TermGenie] synonym: "activation of glomerular podocyte apoptotic process" NARROW [GOC:TermGenie] synonym: "activation of glomerular visceral epithelial cell apoptosis" NARROW [GOC:TermGenie] synonym: "activation of glomerular visceral epithelial cell apoptotic process" NARROW [GOC:TermGenie] synonym: "activation of podocyte apoptosis" NARROW [GOC:TermGenie] synonym: "activation of podocyte apoptotic process" NARROW [GOC:TermGenie] synonym: "positive regulation of glomerular podocyte apoptosis" NARROW [GOC:TermGenie] synonym: "positive regulation of glomerular podocyte apoptotic process" EXACT [GOC:TermGenie] synonym: "positive regulation of glomerular visceral epithelial cell apoptosis" NARROW [GOC:TermGenie] synonym: "positive regulation of glomerular visceral epithelial cell apoptotic process" EXACT [] synonym: "positive regulation of podocyte apoptosis" NARROW [GOC:TermGenie] synonym: "up regulation of glomerular podocyte apoptosis" NARROW [GOC:TermGenie] synonym: "up regulation of glomerular podocyte apoptotic process" EXACT [GOC:TermGenie] synonym: "up regulation of glomerular visceral epithelial cell apoptosis" NARROW [GOC:TermGenie] synonym: "up regulation of glomerular visceral epithelial cell apoptotic process" EXACT [GOC:TermGenie] synonym: "up regulation of podocyte apoptosis" NARROW [GOC:TermGenie] synonym: "up regulation of podocyte apoptotic process" EXACT [GOC:TermGenie] synonym: "up-regulation of glomerular podocyte apoptosis" NARROW [GOC:TermGenie] synonym: "up-regulation of glomerular podocyte apoptotic process" EXACT [GOC:TermGenie] synonym: "up-regulation of glomerular visceral epithelial cell apoptosis" NARROW [GOC:TermGenie] synonym: "up-regulation of glomerular visceral epithelial cell apoptotic process" EXACT [GOC:TermGenie] synonym: "up-regulation of podocyte apoptosis" NARROW [GOC:TermGenie] synonym: "up-regulation of podocyte apoptotic process" EXACT [GOC:TermGenie] synonym: "upregulation of glomerular podocyte apoptosis" NARROW [GOC:TermGenie] synonym: "upregulation of glomerular podocyte apoptotic process" EXACT [GOC:TermGenie] synonym: "upregulation of glomerular visceral epithelial cell apoptosis" NARROW [GOC:TermGenie] synonym: "upregulation of glomerular visceral epithelial cell apoptotic process" EXACT [GOC:TermGenie] synonym: "upregulation of podocyte apoptosis" NARROW [GOC:TermGenie] synonym: "upregulation of podocyte apoptotic process" EXACT [GOC:TermGenie] is_a: GO:1904037 ! positive regulation of epithelial cell apoptotic process is_a: GO:1904633 ! regulation of podocyte apoptotic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:1903210 ! positively regulates podocyte apoptotic process relationship: RO:0002213 GO:1903210 ! positively regulates podocyte apoptotic process property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/23000" xsd:anyURI property_value: RO:0002161 NCBITaxon:4751 creation_date: 2015-08-28T14:14:56Z [Term] id: GO:1904649 name: regulation of fat cell apoptotic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of fat cell apoptotic process." [GO_REF:0000058, GOC:TermGenie, PMID:17024416] synonym: "regulation of adipocyte apoptosis" NARROW [GOC:TermGenie] synonym: "regulation of adipocyte apoptotic process" EXACT [GOC:TermGenie] synonym: "regulation of adipose cell apoptosis" NARROW [GOC:TermGenie] synonym: "regulation of adipose cell apoptotic process" EXACT [GOC:TermGenie] synonym: "regulation of fat cell apoptosis" NARROW [GOC:TermGenie] is_a: GO:0042981 ! regulation of apoptotic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:1904606 ! regulates fat cell apoptotic process relationship: RO:0002211 GO:1904606 ! regulates fat cell apoptotic process property_value: RO:0002161 NCBITaxon:4896 creation_date: 2015-08-31T20:59:28Z [Term] id: GO:1904650 name: negative regulation of fat cell apoptotic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of fat cell apoptotic process." [GO_REF:0000058, GOC:TermGenie, PMID:17024416] synonym: "down regulation of adipocyte apoptosis" NARROW [GOC:TermGenie] synonym: "down regulation of adipocyte apoptotic process" EXACT [GOC:TermGenie] synonym: "down regulation of adipose cell apoptosis" NARROW [GOC:TermGenie] synonym: "down regulation of adipose cell apoptotic process" EXACT [GOC:TermGenie] synonym: "down regulation of fat cell apoptosis" NARROW [GOC:TermGenie] synonym: "down regulation of fat cell apoptotic process" EXACT [GOC:TermGenie] synonym: "down-regulation of adipocyte apoptosis" NARROW [GOC:TermGenie] synonym: "down-regulation of adipocyte apoptotic process" EXACT [GOC:TermGenie] synonym: "down-regulation of adipose cell apoptosis" NARROW [GOC:TermGenie] synonym: "down-regulation of adipose cell apoptotic process" EXACT [GOC:TermGenie] synonym: "down-regulation of fat cell apoptosis" NARROW [GOC:TermGenie] synonym: "down-regulation of fat cell apoptotic process" EXACT [GOC:TermGenie] synonym: "downregulation of adipocyte apoptosis" NARROW [GOC:TermGenie] synonym: "downregulation of adipocyte apoptotic process" EXACT [GOC:TermGenie] synonym: "downregulation of adipose cell apoptosis" NARROW [GOC:TermGenie] synonym: "downregulation of adipose cell apoptotic process" EXACT [GOC:TermGenie] synonym: "downregulation of fat cell apoptosis" NARROW [GOC:TermGenie] synonym: "downregulation of fat cell apoptotic process" EXACT [GOC:TermGenie] synonym: "inhibition of adipocyte apoptosis" NARROW [GOC:TermGenie] synonym: "inhibition of adipocyte apoptotic process" NARROW [GOC:TermGenie] synonym: "inhibition of adipose cell apoptosis" NARROW [GOC:TermGenie] synonym: "inhibition of adipose cell apoptotic process" NARROW [GOC:TermGenie] synonym: "inhibition of fat cell apoptosis" NARROW [GOC:TermGenie] synonym: "inhibition of fat cell apoptotic process" NARROW [GOC:TermGenie] synonym: "negative regulation of adipocyte apoptosis" NARROW [GOC:TermGenie] synonym: "negative regulation of adipocyte apoptotic process" EXACT [GOC:TermGenie] synonym: "negative regulation of adipose cell apoptosis" NARROW [GOC:TermGenie] synonym: "negative regulation of adipose cell apoptotic process" EXACT [GOC:TermGenie] synonym: "negative regulation of fat cell apoptosis" NARROW [GOC:TermGenie] is_a: GO:0043066 ! negative regulation of apoptotic process is_a: GO:1904649 ! regulation of fat cell apoptotic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:1904606 ! negatively regulates fat cell apoptotic process relationship: RO:0002212 GO:1904606 ! negatively regulates fat cell apoptotic process property_value: RO:0002161 NCBITaxon:4896 creation_date: 2015-08-31T20:59:34Z [Term] id: GO:1904651 name: positive regulation of fat cell apoptotic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of fat cell apoptotic process." [GO_REF:0000058, GOC:TermGenie, PMID:17024416] synonym: "activation of adipocyte apoptosis" NARROW [GOC:TermGenie] synonym: "activation of adipocyte apoptotic process" NARROW [GOC:TermGenie] synonym: "activation of adipose cell apoptosis" NARROW [GOC:TermGenie] synonym: "activation of adipose cell apoptotic process" NARROW [GOC:TermGenie] synonym: "activation of fat cell apoptosis" NARROW [GOC:TermGenie] synonym: "activation of fat cell apoptotic process" NARROW [GOC:TermGenie] synonym: "positive regulation of adipocyte apoptosis" NARROW [GOC:TermGenie] synonym: "positive regulation of adipocyte apoptotic process" EXACT [GOC:TermGenie] synonym: "positive regulation of adipose cell apoptosis" NARROW [GOC:TermGenie] synonym: "positive regulation of adipose cell apoptotic process" EXACT [GOC:TermGenie] synonym: "positive regulation of fat cell apoptosis" NARROW [GOC:TermGenie] synonym: "up regulation of adipocyte apoptosis" NARROW [GOC:TermGenie] synonym: "up regulation of adipocyte apoptotic process" EXACT [GOC:TermGenie] synonym: "up regulation of adipose cell apoptosis" NARROW [GOC:TermGenie] synonym: "up regulation of adipose cell apoptotic process" EXACT [GOC:TermGenie] synonym: "up regulation of fat cell apoptosis" NARROW [GOC:TermGenie] synonym: "up regulation of fat cell apoptotic process" EXACT [GOC:TermGenie] synonym: "up-regulation of adipocyte apoptosis" NARROW [GOC:TermGenie] synonym: "up-regulation of adipocyte apoptotic process" EXACT [GOC:TermGenie] synonym: "up-regulation of adipose cell apoptosis" NARROW [GOC:TermGenie] synonym: "up-regulation of adipose cell apoptotic process" EXACT [GOC:TermGenie] synonym: "up-regulation of fat cell apoptosis" NARROW [GOC:TermGenie] synonym: "up-regulation of fat cell apoptotic process" EXACT [GOC:TermGenie] synonym: "upregulation of adipocyte apoptosis" NARROW [GOC:TermGenie] synonym: "upregulation of adipocyte apoptotic process" EXACT [GOC:TermGenie] synonym: "upregulation of adipose cell apoptosis" NARROW [GOC:TermGenie] synonym: "upregulation of adipose cell apoptotic process" EXACT [GOC:TermGenie] synonym: "upregulation of fat cell apoptosis" NARROW [GOC:TermGenie] synonym: "upregulation of fat cell apoptotic process" EXACT [GOC:TermGenie] is_a: GO:0043065 ! positive regulation of apoptotic process is_a: GO:1904649 ! regulation of fat cell apoptotic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:1904606 ! positively regulates fat cell apoptotic process relationship: RO:0002213 GO:1904606 ! positively regulates fat cell apoptotic process property_value: RO:0002161 NCBITaxon:4896 creation_date: 2015-08-31T20:59:40Z [Term] id: GO:1904653 name: regulation of lung alveolus development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of lung alveolus development." [GO_REF:0000058, GOC:TermGenie, PMID:23962064] synonym: "regulation of alveolarization" EXACT [GOC:TermGenie] synonym: "regulation of alveologenesis" EXACT [GOC:TermGenie] is_a: GO:0050793 ! regulation of developmental process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0048286 ! regulates lung alveolus development relationship: RO:0002211 GO:0048286 ! regulates lung alveolus development creation_date: 2015-09-03T22:44:44Z [Term] id: GO:1904654 name: negative regulation of lung alveolus development namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of lung alveolus development." [GO_REF:0000058, GOC:TermGenie, PMID:23962064] synonym: "down regulation of alveolarization" EXACT [GOC:TermGenie] synonym: "down regulation of alveologenesis" EXACT [GOC:TermGenie] synonym: "down regulation of lung alveolus development" EXACT [GOC:TermGenie] synonym: "down-regulation of alveolarization" EXACT [GOC:TermGenie] synonym: "down-regulation of alveologenesis" EXACT [GOC:TermGenie] synonym: "down-regulation of lung alveolus development" EXACT [GOC:TermGenie] synonym: "downregulation of alveolarization" EXACT [GOC:TermGenie] synonym: "downregulation of alveologenesis" EXACT [GOC:TermGenie] synonym: "downregulation of lung alveolus development" EXACT [GOC:TermGenie] synonym: "inhibition of alveolarization" NARROW [GOC:TermGenie] synonym: "inhibition of alveologenesis" NARROW [GOC:TermGenie] synonym: "inhibition of lung alveolus development" NARROW [GOC:TermGenie] synonym: "negative regulation of alveolarization" EXACT [GOC:TermGenie] synonym: "negative regulation of alveologenesis" EXACT [GOC:TermGenie] is_a: GO:0051093 ! negative regulation of developmental process is_a: GO:0051241 ! negative regulation of multicellular organismal process is_a: GO:1904653 ! regulation of lung alveolus development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0048286 ! negatively regulates lung alveolus development relationship: RO:0002212 GO:0048286 ! negatively regulates lung alveolus development creation_date: 2015-09-03T22:44:50Z [Term] id: GO:1904655 name: positive regulation of lung alveolus development namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of lung alveolus development." [GO_REF:0000058, GOC:TermGenie, PMID:23962064] synonym: "activation of alveolarization" NARROW [GOC:TermGenie] synonym: "activation of alveologenesis" NARROW [GOC:TermGenie] synonym: "activation of lung alveolus development" NARROW [GOC:TermGenie] synonym: "positive regulation of alveolarization" EXACT [GOC:TermGenie] synonym: "positive regulation of alveologenesis" EXACT [GOC:TermGenie] synonym: "up regulation of alveolarization" EXACT [GOC:TermGenie] synonym: "up regulation of alveologenesis" EXACT [GOC:TermGenie] synonym: "up regulation of lung alveolus development" EXACT [GOC:TermGenie] synonym: "up-regulation of alveolarization" EXACT [GOC:TermGenie] synonym: "up-regulation of alveologenesis" EXACT [GOC:TermGenie] synonym: "up-regulation of lung alveolus development" EXACT [GOC:TermGenie] synonym: "upregulation of alveolarization" EXACT [GOC:TermGenie] synonym: "upregulation of alveologenesis" EXACT [GOC:TermGenie] synonym: "upregulation of lung alveolus development" EXACT [GOC:TermGenie] is_a: GO:0051094 ! positive regulation of developmental process is_a: GO:0051240 ! positive regulation of multicellular organismal process is_a: GO:1904653 ! regulation of lung alveolus development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0048286 ! positively regulates lung alveolus development relationship: RO:0002213 GO:0048286 ! positively regulates lung alveolus development creation_date: 2015-09-03T22:44:56Z [Term] id: GO:1904659 name: D-glucose transmembrane transport namespace: biological_process def: "The process in which D-glucose is transported across a membrane." [GO_REF:0000069, GOC:TermGenie, PMID:9090050] synonym: "glucose transmembrane transport" EXACT [] synonym: "glucose transport" RELATED [] is_a: GO:0008645 ! hexose transmembrane transport intersection_of: GO:0055085 ! transmembrane transport intersection_of: RO:0004009 CHEBI:4167 ! has primary input relationship: RO:0004009 CHEBI:4167 ! has primary input creation_date: 2015-09-04T17:20:16Z [Term] id: GO:1904671 name: negative regulation of cell differentiation involved in stem cell population maintenance namespace: biological_process def: "Any negative regulation of cell differentiation that is involved in stem cell population maintenance." [GO_REF:0000060, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:19409607] synonym: "down regulation of cell differentiation involved in maintenance of pluripotency" RELATED [GOC:TermGenie] synonym: "down regulation of cell differentiation involved in stem cell population maintenance" EXACT [GOC:TermGenie] synonym: "down-regulation of cell differentiation involved in maintenance of pluripotency" RELATED [GOC:TermGenie] synonym: "down-regulation of cell differentiation involved in stem cell population maintenance" EXACT [GOC:TermGenie] synonym: "downregulation of cell differentiation involved in maintenance of pluripotency" RELATED [GOC:TermGenie] synonym: "downregulation of cell differentiation involved in stem cell population maintenance" EXACT [GOC:TermGenie] synonym: "inhibition of cell differentiation involved in maintenance of pluripotency" RELATED [GOC:TermGenie] synonym: "inhibition of cell differentiation involved in stem cell population maintenance" NARROW [GOC:TermGenie] synonym: "negative regulation of cell differentiation involved in maintenance of pluripotency" RELATED [GOC:TermGenie] is_a: GO:0045596 ! negative regulation of cell differentiation intersection_of: GO:0045596 ! negative regulation of cell differentiation intersection_of: BFO:0000050 GO:0019827 ! part of stem cell population maintenance relationship: BFO:0000050 GO:0019827 ! part of stem cell population maintenance property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 creation_date: 2015-09-12T00:46:08Z [Term] id: GO:1904672 name: regulation of somatic stem cell population maintenance namespace: biological_process def: "Any process that modulates the frequency, rate or extent of somatic stem cell population maintenance." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:19409607] is_a: GO:2000036 ! regulation of stem cell population maintenance intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0035019 ! regulates somatic stem cell population maintenance relationship: RO:0002211 GO:0035019 ! regulates somatic stem cell population maintenance property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4751 creation_date: 2015-09-14T08:40:19Z [Term] id: GO:1904673 name: negative regulation of somatic stem cell population maintenance namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of somatic stem cell population maintenance." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:19409607] synonym: "down regulation of somatic stem cell population maintenance" EXACT [GOC:TermGenie] synonym: "down-regulation of somatic stem cell population maintenance" EXACT [GOC:TermGenie] synonym: "downregulation of somatic stem cell population maintenance" EXACT [GOC:TermGenie] synonym: "inhibition of somatic stem cell population maintenance" NARROW [GOC:TermGenie] is_a: GO:1902455 ! negative regulation of stem cell population maintenance is_a: GO:1904672 ! regulation of somatic stem cell population maintenance intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0035019 ! negatively regulates somatic stem cell population maintenance relationship: RO:0002212 GO:0035019 ! negatively regulates somatic stem cell population maintenance property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4751 creation_date: 2015-09-14T08:40:25Z [Term] id: GO:1904674 name: positive regulation of somatic stem cell population maintenance namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of somatic stem cell population maintenance." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:19409607] synonym: "activation of somatic stem cell population maintenance" NARROW [GOC:TermGenie] synonym: "up regulation of somatic stem cell population maintenance" EXACT [GOC:TermGenie] synonym: "up-regulation of somatic stem cell population maintenance" EXACT [GOC:TermGenie] synonym: "upregulation of somatic stem cell population maintenance" EXACT [GOC:TermGenie] is_a: GO:1902459 ! positive regulation of stem cell population maintenance is_a: GO:1904672 ! regulation of somatic stem cell population maintenance intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0035019 ! positively regulates somatic stem cell population maintenance relationship: RO:0002213 GO:0035019 ! positively regulates somatic stem cell population maintenance property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4751 creation_date: 2015-09-14T08:40:32Z [Term] id: GO:1904675 name: regulation of somatic stem cell division namespace: biological_process def: "Any process that modulates the frequency, rate or extent of somatic stem cell division." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:19409607] synonym: "regulation of somatic stem cell renewal" EXACT [GOC:TermGenie] is_a: GO:2000035 ! regulation of stem cell division intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0048103 ! regulates somatic stem cell division relationship: RO:0002211 GO:0048103 ! regulates somatic stem cell division property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4751 creation_date: 2015-09-14T08:47:22Z [Term] id: GO:1904676 name: negative regulation of somatic stem cell division namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of somatic stem cell division." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:19409607] synonym: "down regulation of somatic stem cell division" EXACT [GOC:TermGenie] synonym: "down regulation of somatic stem cell renewal" EXACT [GOC:TermGenie] synonym: "down-regulation of somatic stem cell division" EXACT [GOC:TermGenie] synonym: "down-regulation of somatic stem cell renewal" EXACT [GOC:TermGenie] synonym: "downregulation of somatic stem cell division" EXACT [GOC:TermGenie] synonym: "downregulation of somatic stem cell renewal" EXACT [GOC:TermGenie] synonym: "inhibition of somatic stem cell division" NARROW [GOC:TermGenie] synonym: "inhibition of somatic stem cell renewal" NARROW [GOC:TermGenie] synonym: "negative regulation of somatic stem cell renewal" EXACT [GOC:TermGenie] is_a: GO:0051782 ! negative regulation of cell division is_a: GO:1904675 ! regulation of somatic stem cell division intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0048103 ! negatively regulates somatic stem cell division relationship: RO:0002212 GO:0048103 ! negatively regulates somatic stem cell division property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4751 creation_date: 2015-09-14T08:47:28Z [Term] id: GO:1904677 name: positive regulation of somatic stem cell division namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of somatic stem cell division." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:19409607] synonym: "activation of somatic stem cell division" NARROW [GOC:TermGenie] synonym: "activation of somatic stem cell renewal" NARROW [GOC:TermGenie] synonym: "positive regulation of somatic stem cell renewal" EXACT [GOC:TermGenie] synonym: "up regulation of somatic stem cell division" EXACT [GOC:TermGenie] synonym: "up regulation of somatic stem cell renewal" EXACT [GOC:TermGenie] synonym: "up-regulation of somatic stem cell division" EXACT [GOC:TermGenie] synonym: "up-regulation of somatic stem cell renewal" EXACT [GOC:TermGenie] synonym: "upregulation of somatic stem cell division" EXACT [GOC:TermGenie] synonym: "upregulation of somatic stem cell renewal" EXACT [GOC:TermGenie] is_a: GO:0051781 ! positive regulation of cell division is_a: GO:1904675 ! regulation of somatic stem cell division intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0048103 ! positively regulates somatic stem cell division relationship: RO:0002213 GO:0048103 ! positively regulates somatic stem cell division property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4751 creation_date: 2015-09-14T08:47:34Z [Term] id: GO:1904680 name: peptide transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of a peptide from one side of a membrane to the other." [GO_REF:0000070, GOC:TermGenie, GOC:vw] synonym: "peptide transporter activity" RELATED [] synonym: "peptide uptake permease activity" RELATED [] xref: Reactome:R-HSA-1500817 "Glutathione is taken up by the bacterium" is_a: GO:0022857 ! transmembrane transporter activity intersection_of: GO:0005215 ! transporter activity intersection_of: RO:0002342 GO:0016020 ! results in transport across membrane intersection_of: RO:0004009 CHEBI:60466 ! has primary input relationship: RO:0004009 CHEBI:60466 ! has primary input creation_date: 2015-09-22T18:50:41Z [Term] id: GO:1904688 name: regulation of cytoplasmic translational initiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cytoplasmic translational initiation." [GO_REF:0000058, GOC:TermGenie, PMID:12242291] is_a: GO:0006446 ! regulation of translational initiation is_a: GO:2000765 ! regulation of cytoplasmic translation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0002183 ! regulates cytoplasmic translational initiation relationship: RO:0002211 GO:0002183 ! regulates cytoplasmic translational initiation property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/21560" xsd:anyURI creation_date: 2015-09-25T14:39:38Z [Term] id: GO:1904689 name: negative regulation of cytoplasmic translational initiation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of cytoplasmic translational initiation." [GO_REF:0000058, GOC:TermGenie, PMID:12242291] synonym: "down regulation of cytoplasmic translational initiation" EXACT [GOC:TermGenie] synonym: "down-regulation of cytoplasmic translational initiation" EXACT [GOC:TermGenie] synonym: "downregulation of cytoplasmic translational initiation" EXACT [GOC:TermGenie] synonym: "inhibition of cytoplasmic translational initiation" NARROW [GOC:TermGenie] is_a: GO:0045947 ! negative regulation of translational initiation is_a: GO:1904688 ! regulation of cytoplasmic translational initiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0002183 ! negatively regulates cytoplasmic translational initiation relationship: RO:0002212 GO:0002183 ! negatively regulates cytoplasmic translational initiation creation_date: 2015-09-25T14:39:44Z [Term] id: GO:1904690 name: positive regulation of cytoplasmic translational initiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cytoplasmic translational initiation." [GO_REF:0000058, GOC:TermGenie, PMID:12242291] synonym: "activation of cytoplasmic translational initiation" NARROW [GOC:TermGenie] synonym: "up regulation of cytoplasmic translational initiation" EXACT [GOC:TermGenie] synonym: "up-regulation of cytoplasmic translational initiation" EXACT [GOC:TermGenie] synonym: "upregulation of cytoplasmic translational initiation" EXACT [GOC:TermGenie] is_a: GO:0045948 ! positive regulation of translational initiation is_a: GO:1904688 ! regulation of cytoplasmic translational initiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0002183 ! positively regulates cytoplasmic translational initiation relationship: RO:0002213 GO:0002183 ! positively regulates cytoplasmic translational initiation creation_date: 2015-09-25T14:39:50Z [Term] id: GO:1904691 name: negative regulation of type B pancreatic cell proliferation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of type B pancreatic cell proliferation." [GO_REF:0000058, GOC:TermGenie, PMID:24055447] synonym: "down regulation of pancreatic B cell proliferation" EXACT [GOC:TermGenie] synonym: "down regulation of pancreatic beta cell proliferation" EXACT [GOC:TermGenie] synonym: "down regulation of type B pancreatic cell proliferation" EXACT [GOC:TermGenie] synonym: "down-regulation of pancreatic B cell proliferation" EXACT [GOC:TermGenie] synonym: "down-regulation of pancreatic beta cell proliferation" EXACT [GOC:TermGenie] synonym: "down-regulation of type B pancreatic cell proliferation" EXACT [GOC:TermGenie] synonym: "downregulation of pancreatic B cell proliferation" EXACT [GOC:TermGenie] synonym: "downregulation of pancreatic beta cell proliferation" EXACT [GOC:TermGenie] synonym: "downregulation of type B pancreatic cell proliferation" EXACT [GOC:TermGenie] synonym: "inhibition of pancreatic B cell proliferation" NARROW [GOC:TermGenie] synonym: "inhibition of pancreatic beta cell proliferation" NARROW [GOC:TermGenie] synonym: "inhibition of type B pancreatic cell proliferation" NARROW [GOC:TermGenie] synonym: "negative regulation of pancreatic B cell proliferation" EXACT [GOC:TermGenie] synonym: "negative regulation of pancreatic beta cell proliferation" EXACT [GOC:TermGenie] is_a: GO:0050680 ! negative regulation of epithelial cell proliferation is_a: GO:0061469 ! regulation of type B pancreatic cell proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0044342 ! negatively regulates type B pancreatic cell proliferation relationship: RO:0002212 GO:0044342 ! negatively regulates type B pancreatic cell proliferation property_value: RO:0002161 NCBITaxon:4751 creation_date: 2015-09-25T15:23:38Z [Term] id: GO:1904692 name: positive regulation of type B pancreatic cell proliferation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of type B pancreatic cell proliferation." [GO_REF:0000058, GOC:TermGenie, PMID:24055447] synonym: "activation of pancreatic B cell proliferation" NARROW [GOC:TermGenie] synonym: "activation of pancreatic beta cell proliferation" NARROW [GOC:TermGenie] synonym: "activation of type B pancreatic cell proliferation" NARROW [GOC:TermGenie] synonym: "positive regulation of pancreatic B cell proliferation" EXACT [GOC:TermGenie] synonym: "positive regulation of pancreatic beta cell proliferation" EXACT [GOC:TermGenie] synonym: "up regulation of pancreatic B cell proliferation" EXACT [GOC:TermGenie] synonym: "up regulation of pancreatic beta cell proliferation" EXACT [GOC:TermGenie] synonym: "up regulation of type B pancreatic cell proliferation" EXACT [GOC:TermGenie] synonym: "up-regulation of pancreatic B cell proliferation" EXACT [GOC:TermGenie] synonym: "up-regulation of pancreatic beta cell proliferation" EXACT [GOC:TermGenie] synonym: "up-regulation of type B pancreatic cell proliferation" EXACT [GOC:TermGenie] synonym: "upregulation of pancreatic B cell proliferation" EXACT [GOC:TermGenie] synonym: "upregulation of pancreatic beta cell proliferation" EXACT [GOC:TermGenie] synonym: "upregulation of type B pancreatic cell proliferation" EXACT [GOC:TermGenie] is_a: GO:0050679 ! positive regulation of epithelial cell proliferation is_a: GO:0061469 ! regulation of type B pancreatic cell proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0044342 ! positively regulates type B pancreatic cell proliferation relationship: RO:0002213 GO:0044342 ! positively regulates type B pancreatic cell proliferation property_value: RO:0002161 NCBITaxon:4751 creation_date: 2015-09-25T15:23:44Z [Term] id: GO:1904693 name: midbrain morphogenesis namespace: biological_process def: "The developmental process by which a midbrain is generated and organized." [GO_REF:0000083, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:21347250] synonym: "MB morphogenesis" BROAD [GOC:TermGenie] synonym: "mesencephalon morphogenesis" RELATED [GOC:TermGenie] is_a: BFO:0000003 is_a: GO:0009653 ! anatomical structure morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0001891 ! results in morphogenesis of midbrain relationship: BFO:0000050 GO:0030901 ! part of midbrain development relationship: BFO:0000050 GO:0048854 ! part of brain morphogenesis relationship: RO:0002298 UBERON:0001891 ! results in morphogenesis of midbrain creation_date: 2015-09-29T09:15:28Z [Term] id: GO:1904697 name: regulation of acinar cell proliferation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of acinar cell proliferation." [GO_REF:0000058, GOC:TermGenie, PMID:9788538] synonym: "regulation of acinic cell proliferation" EXACT [GOC:TermGenie] synonym: "regulation of acinous cell proliferation" EXACT [GOC:TermGenie] is_a: GO:0050678 ! regulation of epithelial cell proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:1990863 ! regulates acinar cell proliferation relationship: RO:0002211 GO:1990863 ! regulates acinar cell proliferation property_value: RO:0002161 NCBITaxon:4751 creation_date: 2015-09-30T15:19:50Z [Term] id: GO:1904698 name: negative regulation of acinar cell proliferation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of acinar cell proliferation." [GO_REF:0000058, GOC:TermGenie, PMID:9788538] synonym: "down regulation of acinar cell proliferation" EXACT [GOC:TermGenie] synonym: "down regulation of acinic cell proliferation" EXACT [GOC:TermGenie] synonym: "down regulation of acinous cell proliferation" EXACT [GOC:TermGenie] synonym: "down-regulation of acinar cell proliferation" EXACT [GOC:TermGenie] synonym: "down-regulation of acinic cell proliferation" EXACT [GOC:TermGenie] synonym: "down-regulation of acinous cell proliferation" EXACT [GOC:TermGenie] synonym: "downregulation of acinar cell proliferation" EXACT [GOC:TermGenie] synonym: "downregulation of acinic cell proliferation" EXACT [GOC:TermGenie] synonym: "downregulation of acinous cell proliferation" EXACT [GOC:TermGenie] synonym: "inhibition of acinar cell proliferation" NARROW [GOC:TermGenie] synonym: "inhibition of acinic cell proliferation" NARROW [GOC:TermGenie] synonym: "inhibition of acinous cell proliferation" NARROW [GOC:TermGenie] synonym: "negative regulation of acinic cell proliferation" EXACT [GOC:TermGenie] synonym: "negative regulation of acinous cell proliferation" EXACT [GOC:TermGenie] is_a: GO:0050680 ! negative regulation of epithelial cell proliferation is_a: GO:1904697 ! regulation of acinar cell proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:1990863 ! negatively regulates acinar cell proliferation relationship: RO:0002212 GO:1990863 ! negatively regulates acinar cell proliferation property_value: RO:0002161 NCBITaxon:4751 creation_date: 2015-09-30T15:19:57Z [Term] id: GO:1904699 name: positive regulation of acinar cell proliferation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of acinar cell proliferation." [GO_REF:0000058, GOC:TermGenie, PMID:9788538] synonym: "activation of acinar cell proliferation" NARROW [GOC:TermGenie] synonym: "activation of acinic cell proliferation" NARROW [GOC:TermGenie] synonym: "activation of acinous cell proliferation" NARROW [GOC:TermGenie] synonym: "positive regulation of acinic cell proliferation" EXACT [GOC:TermGenie] synonym: "positive regulation of acinous cell proliferation" EXACT [GOC:TermGenie] synonym: "up regulation of acinar cell proliferation" EXACT [GOC:TermGenie] synonym: "up regulation of acinic cell proliferation" EXACT [GOC:TermGenie] synonym: "up regulation of acinous cell proliferation" EXACT [GOC:TermGenie] synonym: "up-regulation of acinar cell proliferation" EXACT [GOC:TermGenie] synonym: "up-regulation of acinic cell proliferation" EXACT [GOC:TermGenie] synonym: "up-regulation of acinous cell proliferation" EXACT [GOC:TermGenie] synonym: "upregulation of acinar cell proliferation" EXACT [GOC:TermGenie] synonym: "upregulation of acinic cell proliferation" EXACT [GOC:TermGenie] synonym: "upregulation of acinous cell proliferation" EXACT [GOC:TermGenie] is_a: GO:0050679 ! positive regulation of epithelial cell proliferation is_a: GO:1904697 ! regulation of acinar cell proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:1990863 ! positively regulates acinar cell proliferation relationship: RO:0002213 GO:1990863 ! positively regulates acinar cell proliferation property_value: RO:0002161 NCBITaxon:4751 creation_date: 2015-09-30T15:20:03Z [Term] id: GO:1904700 name: granulosa cell apoptotic process namespace: biological_process def: "Any apoptotic process in a granulosa cell." [GO_REF:0000085, GOC:TermGenie, PMID:19208546] synonym: "granulosa cell apoptosis" NARROW [GOC:TermGenie] synonym: "granulosa cell of ovary apoptosis" NARROW [GOC:TermGenie] synonym: "granulosa cell of ovary apoptotic process" EXACT [GOC:TermGenie] is_a: GO:1904019 ! epithelial cell apoptotic process intersection_of: GO:0006915 ! apoptotic process intersection_of: BFO:0000066 CL:0000501 ! occurs in granulosa cell relationship: BFO:0000066 CL:0000501 ! occurs in granulosa cell property_value: RO:0002161 NCBITaxon:4751 creation_date: 2015-09-30T21:29:54Z [Term] id: GO:1904705 name: regulation of vascular associated smooth muscle cell proliferation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of vascular smooth muscle cell proliferation." [GO_REF:0000058, GOC:TermGenie, PMID:23246467] synonym: "regulation of vascular smooth muscle cell proliferation" EXACT [] synonym: "regulation of VSMC proliferation" EXACT [GOC:TermGenie] is_a: GO:0048660 ! regulation of smooth muscle cell proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:1990874 ! regulates vascular associated smooth muscle cell proliferation relationship: RO:0002211 GO:1990874 ! regulates vascular associated smooth muscle cell proliferation property_value: RO:0002161 NCBITaxon:4751 creation_date: 2015-10-01T16:05:20Z [Term] id: GO:1904706 name: negative regulation of vascular associated smooth muscle cell proliferation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of vascular smooth muscle cell proliferation." [GO_REF:0000058, GOC:TermGenie, PMID:23246467] synonym: "down regulation of vascular smooth muscle cell proliferation" EXACT [GOC:TermGenie] synonym: "down regulation of VSMC proliferation" EXACT [GOC:TermGenie] synonym: "down-regulation of vascular smooth muscle cell proliferation" EXACT [GOC:TermGenie] synonym: "down-regulation of VSMC proliferation" EXACT [GOC:TermGenie] synonym: "downregulation of vascular smooth muscle cell proliferation" EXACT [GOC:TermGenie] synonym: "downregulation of VSMC proliferation" EXACT [GOC:TermGenie] synonym: "inhibition of vascular smooth muscle cell proliferation" NARROW [GOC:TermGenie] synonym: "inhibition of VSMC proliferation" NARROW [GOC:TermGenie] synonym: "negative regulation of vascular smooth muscle cell proliferation" EXACT [] synonym: "negative regulation of VSMC proliferation" EXACT [GOC:TermGenie] is_a: GO:0048662 ! negative regulation of smooth muscle cell proliferation is_a: GO:1904705 ! regulation of vascular associated smooth muscle cell proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:1990874 ! negatively regulates vascular associated smooth muscle cell proliferation relationship: RO:0002212 GO:1990874 ! negatively regulates vascular associated smooth muscle cell proliferation property_value: RO:0002161 NCBITaxon:4751 creation_date: 2015-10-01T16:05:26Z [Term] id: GO:1904707 name: positive regulation of vascular associated smooth muscle cell proliferation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of vascular smooth muscle cell proliferation." [GO_REF:0000058, GOC:TermGenie, PMID:23246467] synonym: "activation of vascular smooth muscle cell proliferation" NARROW [GOC:TermGenie] synonym: "activation of VSMC proliferation" NARROW [GOC:TermGenie] synonym: "positive regulation of vascular smooth muscle cell proliferation" EXACT [] synonym: "positive regulation of VSMC proliferation" EXACT [GOC:TermGenie] synonym: "up regulation of vascular smooth muscle cell proliferation" EXACT [GOC:TermGenie] synonym: "up regulation of VSMC proliferation" EXACT [GOC:TermGenie] synonym: "up-regulation of vascular smooth muscle cell proliferation" EXACT [GOC:TermGenie] synonym: "up-regulation of VSMC proliferation" EXACT [GOC:TermGenie] synonym: "upregulation of vascular smooth muscle cell proliferation" EXACT [GOC:TermGenie] synonym: "upregulation of VSMC proliferation" EXACT [GOC:TermGenie] is_a: GO:0048661 ! positive regulation of smooth muscle cell proliferation is_a: GO:1904705 ! regulation of vascular associated smooth muscle cell proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:1990874 ! positively regulates vascular associated smooth muscle cell proliferation relationship: RO:0002213 GO:1990874 ! positively regulates vascular associated smooth muscle cell proliferation property_value: RO:0002161 NCBITaxon:4751 creation_date: 2015-10-01T16:05:32Z [Term] id: GO:1904708 name: regulation of granulosa cell apoptotic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of granulosa cell apoptotic process." [GO_REF:0000058, GOC:TermGenie, PMID:19208546] synonym: "regulation of granulosa cell apoptosis" NARROW [GOC:TermGenie] synonym: "regulation of granulosa cell of ovary apoptosis" NARROW [GOC:TermGenie] synonym: "regulation of granulosa cell of ovary apoptotic process" EXACT [GOC:TermGenie] is_a: GO:1904035 ! regulation of epithelial cell apoptotic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:1904700 ! regulates granulosa cell apoptotic process relationship: RO:0002211 GO:1904700 ! regulates granulosa cell apoptotic process property_value: RO:0002161 NCBITaxon:4751 creation_date: 2015-10-01T16:09:38Z [Term] id: GO:1904709 name: negative regulation of granulosa cell apoptotic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of granulosa cell apoptotic process." [GO_REF:0000058, GOC:TermGenie, PMID:19208546] synonym: "down regulation of granulosa cell apoptosis" NARROW [GOC:TermGenie] synonym: "down regulation of granulosa cell apoptotic process" EXACT [GOC:TermGenie] synonym: "down regulation of granulosa cell of ovary apoptosis" NARROW [GOC:TermGenie] synonym: "down regulation of granulosa cell of ovary apoptotic process" EXACT [GOC:TermGenie] synonym: "down-regulation of granulosa cell apoptosis" NARROW [GOC:TermGenie] synonym: "down-regulation of granulosa cell apoptotic process" EXACT [GOC:TermGenie] synonym: "down-regulation of granulosa cell of ovary apoptosis" NARROW [GOC:TermGenie] synonym: "down-regulation of granulosa cell of ovary apoptotic process" EXACT [GOC:TermGenie] synonym: "downregulation of granulosa cell apoptosis" NARROW [GOC:TermGenie] synonym: "downregulation of granulosa cell apoptotic process" EXACT [GOC:TermGenie] synonym: "downregulation of granulosa cell of ovary apoptosis" NARROW [GOC:TermGenie] synonym: "downregulation of granulosa cell of ovary apoptotic process" EXACT [GOC:TermGenie] synonym: "inhibition of granulosa cell apoptosis" NARROW [GOC:TermGenie] synonym: "inhibition of granulosa cell apoptotic process" NARROW [GOC:TermGenie] synonym: "inhibition of granulosa cell of ovary apoptosis" NARROW [GOC:TermGenie] synonym: "inhibition of granulosa cell of ovary apoptotic process" NARROW [GOC:TermGenie] synonym: "negative regulation of granulosa cell apoptosis" NARROW [GOC:TermGenie] synonym: "negative regulation of granulosa cell of ovary apoptosis" NARROW [GOC:TermGenie] synonym: "negative regulation of granulosa cell of ovary apoptotic process" EXACT [GOC:TermGenie] is_a: GO:1904036 ! negative regulation of epithelial cell apoptotic process is_a: GO:1904708 ! regulation of granulosa cell apoptotic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:1904700 ! negatively regulates granulosa cell apoptotic process relationship: RO:0002212 GO:1904700 ! negatively regulates granulosa cell apoptotic process property_value: RO:0002161 NCBITaxon:4751 creation_date: 2015-10-01T16:09:45Z [Term] id: GO:1904710 name: positive regulation of granulosa cell apoptotic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of granulosa cell apoptotic process." [GO_REF:0000058, GOC:TermGenie, PMID:19208546] synonym: "activation of granulosa cell apoptosis" NARROW [GOC:TermGenie] synonym: "activation of granulosa cell apoptotic process" NARROW [GOC:TermGenie] synonym: "activation of granulosa cell of ovary apoptosis" NARROW [GOC:TermGenie] synonym: "activation of granulosa cell of ovary apoptotic process" NARROW [GOC:TermGenie] synonym: "positive regulation of granulosa cell apoptosis" NARROW [GOC:TermGenie] synonym: "positive regulation of granulosa cell of ovary apoptosis" NARROW [GOC:TermGenie] synonym: "positive regulation of granulosa cell of ovary apoptotic process" EXACT [GOC:TermGenie] synonym: "up regulation of granulosa cell apoptosis" NARROW [GOC:TermGenie] synonym: "up regulation of granulosa cell apoptotic process" EXACT [GOC:TermGenie] synonym: "up regulation of granulosa cell of ovary apoptosis" NARROW [GOC:TermGenie] synonym: "up regulation of granulosa cell of ovary apoptotic process" EXACT [GOC:TermGenie] synonym: "up-regulation of granulosa cell apoptosis" NARROW [GOC:TermGenie] synonym: "up-regulation of granulosa cell apoptotic process" EXACT [GOC:TermGenie] synonym: "up-regulation of granulosa cell of ovary apoptosis" NARROW [GOC:TermGenie] synonym: "up-regulation of granulosa cell of ovary apoptotic process" EXACT [GOC:TermGenie] synonym: "upregulation of granulosa cell apoptosis" NARROW [GOC:TermGenie] synonym: "upregulation of granulosa cell apoptotic process" EXACT [GOC:TermGenie] synonym: "upregulation of granulosa cell of ovary apoptosis" NARROW [GOC:TermGenie] synonym: "upregulation of granulosa cell of ovary apoptotic process" EXACT [GOC:TermGenie] is_a: GO:1904037 ! positive regulation of epithelial cell apoptotic process is_a: GO:1904708 ! regulation of granulosa cell apoptotic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:1904700 ! positively regulates granulosa cell apoptotic process relationship: RO:0002213 GO:1904700 ! positively regulates granulosa cell apoptotic process property_value: RO:0002161 NCBITaxon:4751 creation_date: 2015-10-01T16:09:51Z [Term] id: GO:1904724 name: tertiary granule lumen namespace: cellular_component def: "Any membrane-enclosed lumen that is part of a tertiary granule." [GO_REF:0000064, GOC:TermGenie, PMID:23650620] synonym: "gelatinase granule membrane-enclosed lumen" RELATED [] synonym: "membrane-enclosed lumen of gelatinase granule" EXACT [GOC:TermGenie] synonym: "membrane-enclosed lumen of tertiary granule" EXACT [GOC:TermGenie] synonym: "tertiary granule membrane-enclosed lumen" EXACT [] is_a: GO:0070013 ! intracellular organelle lumen intersection_of: GO:0031974 ! membrane-enclosed lumen intersection_of: BFO:0000050 GO:0070820 ! part of tertiary granule relationship: BFO:0000050 GO:0070820 ! part of tertiary granule property_value: RO:0002161 NCBITaxon:4890 creation_date: 2015-10-12T12:53:10Z [Term] id: GO:1904738 name: vascular associated smooth muscle cell migration namespace: biological_process def: "The orderly movement of a vascular associated smooth muscle cell from one site to another." [GO_REF:0000091, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:20693317] synonym: "vascular smooth muscle cell migration" EXACT [] is_a: GO:0014909 ! smooth muscle cell migration intersection_of: GO:0016477 ! cell migration intersection_of: RO:0002565 CL:0000359 ! results in movement of vascular associated smooth muscle cell relationship: RO:0002565 CL:0000359 ! results in movement of vascular associated smooth muscle cell property_value: RO:0002161 NCBITaxon:4890 creation_date: 2015-10-15T09:56:00Z [Term] id: GO:1904746 name: negative regulation of apoptotic process involved in development namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of apoptotic process involved in development." [GO_REF:0000058, GOC:TermGenie, PMID:22801495] comment: U4PR86 in PMID:22801495 inferred from mutant phenotype synonym: "down regulation of activation of apoptosis involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "down regulation of activation of apoptosis involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "down regulation of apoptosis activator activity involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "down regulation of apoptosis activator activity involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "down regulation of apoptosis involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "down regulation of apoptosis involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "down regulation of apoptosis signaling involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "down regulation of apoptosis signaling involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "down regulation of apoptotic cell death involved in anatomical structure development" EXACT [GOC:TermGenie] synonym: "down regulation of apoptotic cell death involved in development of an anatomical structure" EXACT [GOC:TermGenie] synonym: "down regulation of apoptotic process involved in anatomical structure development" EXACT [GOC:TermGenie] synonym: "down regulation of apoptotic process involved in development" EXACT [GOC:TermGenie] synonym: "down regulation of apoptotic process involved in development of an anatomical structure" EXACT [GOC:TermGenie] synonym: "down regulation of apoptotic program involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "down regulation of apoptotic program involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "down regulation of apoptotic programmed cell death involved in anatomical structure development" EXACT [GOC:TermGenie] synonym: "down regulation of apoptotic programmed cell death involved in development of an anatomical structure" EXACT [GOC:TermGenie] synonym: "down regulation of commitment to apoptosis involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "down regulation of commitment to apoptosis involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "down regulation of induction of apoptosis by p53 involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "down regulation of induction of apoptosis by p53 involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "down regulation of induction of apoptosis involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "down regulation of induction of apoptosis involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "down regulation of programmed cell death by apoptosis involved in anatomical structure development" EXACT [GOC:TermGenie] synonym: "down regulation of programmed cell death by apoptosis involved in development of an anatomical structure" EXACT [GOC:TermGenie] synonym: "down regulation of signaling (initiator) caspase activity involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "down regulation of signaling (initiator) caspase activity involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "down regulation of type I programmed cell death involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "down regulation of type I programmed cell death involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "down-regulation of activation of apoptosis involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "down-regulation of activation of apoptosis involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "down-regulation of apoptosis activator activity involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "down-regulation of apoptosis activator activity involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "down-regulation of apoptosis involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "down-regulation of apoptosis involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "down-regulation of apoptosis signaling involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "down-regulation of apoptosis signaling involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "down-regulation of apoptotic cell death involved in anatomical structure development" EXACT [GOC:TermGenie] synonym: "down-regulation of apoptotic cell death involved in development of an anatomical structure" EXACT [GOC:TermGenie] synonym: "down-regulation of apoptotic process involved in anatomical structure development" EXACT [GOC:TermGenie] synonym: "down-regulation of apoptotic process involved in development" EXACT [GOC:TermGenie] synonym: "down-regulation of apoptotic process involved in development of an anatomical structure" EXACT [GOC:TermGenie] synonym: "down-regulation of apoptotic program involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "down-regulation of apoptotic program involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "down-regulation of apoptotic programmed cell death involved in anatomical structure development" EXACT [GOC:TermGenie] synonym: "down-regulation of apoptotic programmed cell death involved in development of an anatomical structure" EXACT [GOC:TermGenie] synonym: "down-regulation of commitment to apoptosis involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "down-regulation of commitment to apoptosis involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "down-regulation of induction of apoptosis by p53 involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "down-regulation of induction of apoptosis by p53 involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "down-regulation of induction of apoptosis involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "down-regulation of induction of apoptosis involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "down-regulation of programmed cell death by apoptosis involved in anatomical structure development" EXACT [GOC:TermGenie] synonym: "down-regulation of programmed cell death by apoptosis involved in development of an anatomical structure" EXACT [GOC:TermGenie] synonym: "down-regulation of signaling (initiator) caspase activity involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "down-regulation of signaling (initiator) caspase activity involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "down-regulation of type I programmed cell death involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "down-regulation of type I programmed cell death involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "downregulation of activation of apoptosis involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "downregulation of activation of apoptosis involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "downregulation of apoptosis activator activity involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "downregulation of apoptosis activator activity involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "downregulation of apoptosis involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "downregulation of apoptosis involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "downregulation of apoptosis signaling involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "downregulation of apoptosis signaling involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "downregulation of apoptotic cell death involved in anatomical structure development" EXACT [GOC:TermGenie] synonym: "downregulation of apoptotic cell death involved in development of an anatomical structure" EXACT [GOC:TermGenie] synonym: "downregulation of apoptotic process involved in anatomical structure development" EXACT [GOC:TermGenie] synonym: "downregulation of apoptotic process involved in development" EXACT [GOC:TermGenie] synonym: "downregulation of apoptotic process involved in development of an anatomical structure" EXACT [GOC:TermGenie] synonym: "downregulation of apoptotic program involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "downregulation of apoptotic program involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "downregulation of apoptotic programmed cell death involved in anatomical structure development" EXACT [GOC:TermGenie] synonym: "downregulation of apoptotic programmed cell death involved in development of an anatomical structure" EXACT [GOC:TermGenie] synonym: "downregulation of commitment to apoptosis involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "downregulation of commitment to apoptosis involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "downregulation of induction of apoptosis by p53 involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "downregulation of induction of apoptosis by p53 involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "downregulation of induction of apoptosis involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "downregulation of induction of apoptosis involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "downregulation of programmed cell death by apoptosis involved in anatomical structure development" EXACT [GOC:TermGenie] synonym: "downregulation of programmed cell death by apoptosis involved in development of an anatomical structure" EXACT [GOC:TermGenie] synonym: "downregulation of signaling (initiator) caspase activity involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "downregulation of signaling (initiator) caspase activity involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "downregulation of type I programmed cell death involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "downregulation of type I programmed cell death involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "inhibition of activation of apoptosis involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "inhibition of activation of apoptosis involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "inhibition of apoptosis activator activity involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "inhibition of apoptosis activator activity involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "inhibition of apoptosis involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "inhibition of apoptosis involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "inhibition of apoptosis signaling involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "inhibition of apoptosis signaling involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "inhibition of apoptotic cell death involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "inhibition of apoptotic cell death involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "inhibition of apoptotic process involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "inhibition of apoptotic process involved in development" NARROW [GOC:TermGenie] synonym: "inhibition of apoptotic process involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "inhibition of apoptotic program involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "inhibition of apoptotic program involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "inhibition of apoptotic programmed cell death involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "inhibition of apoptotic programmed cell death involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "inhibition of commitment to apoptosis involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "inhibition of commitment to apoptosis involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "inhibition of induction of apoptosis by p53 involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "inhibition of induction of apoptosis by p53 involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "inhibition of induction of apoptosis involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "inhibition of induction of apoptosis involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "inhibition of programmed cell death by apoptosis involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "inhibition of programmed cell death by apoptosis involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "inhibition of signaling (initiator) caspase activity involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "inhibition of signaling (initiator) caspase activity involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "inhibition of type I programmed cell death involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "inhibition of type I programmed cell death involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "negative regulation of activation of apoptosis involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "negative regulation of activation of apoptosis involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "negative regulation of apoptosis activator activity involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "negative regulation of apoptosis activator activity involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "negative regulation of apoptosis involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "negative regulation of apoptosis involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "negative regulation of apoptosis signaling involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "negative regulation of apoptosis signaling involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "negative regulation of apoptotic cell death involved in anatomical structure development" EXACT [GOC:TermGenie] synonym: "negative regulation of apoptotic cell death involved in development of an anatomical structure" EXACT [GOC:TermGenie] synonym: "negative regulation of apoptotic process involved in anatomical structure development" EXACT [GOC:TermGenie] synonym: "negative regulation of apoptotic process involved in development of an anatomical structure" EXACT [GOC:TermGenie] synonym: "negative regulation of apoptotic program involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "negative regulation of apoptotic program involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "negative regulation of apoptotic programmed cell death involved in anatomical structure development" EXACT [GOC:TermGenie] synonym: "negative regulation of apoptotic programmed cell death involved in development of an anatomical structure" EXACT [GOC:TermGenie] synonym: "negative regulation of commitment to apoptosis involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "negative regulation of commitment to apoptosis involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "negative regulation of induction of apoptosis by p53 involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "negative regulation of induction of apoptosis by p53 involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "negative regulation of induction of apoptosis involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "negative regulation of induction of apoptosis involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "negative regulation of programmed cell death by apoptosis involved in anatomical structure development" EXACT [GOC:TermGenie] synonym: "negative regulation of programmed cell death by apoptosis involved in development of an anatomical structure" EXACT [GOC:TermGenie] synonym: "negative regulation of signaling (initiator) caspase activity involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "negative regulation of signaling (initiator) caspase activity involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "negative regulation of type I programmed cell death involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "negative regulation of type I programmed cell death involved in development of an anatomical structure" NARROW [GOC:TermGenie] is_a: GO:0043066 ! negative regulation of apoptotic process is_a: GO:0051093 ! negative regulation of developmental process is_a: GO:1904748 ! regulation of apoptotic process involved in development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:1902742 ! negatively regulates apoptotic process involved in development relationship: RO:0002212 GO:1902742 ! negatively regulates apoptotic process involved in development property_value: RO:0002161 NCBITaxon:4896 creation_date: 2015-10-19T14:12:27Z [Term] id: GO:1904747 name: positive regulation of apoptotic process involved in development namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of apoptotic process involved in development." [GO_REF:0000058, GOC:TermGenie, PMID:22801495] comment: U4PR86 in PMID:22801495 inferred from mutant phenotype synonym: "activation of activation of apoptosis involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "activation of activation of apoptosis involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "activation of apoptosis activator activity involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "activation of apoptosis activator activity involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "activation of apoptosis involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "activation of apoptosis involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "activation of apoptosis signaling involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "activation of apoptosis signaling involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "activation of apoptotic cell death involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "activation of apoptotic cell death involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "activation of apoptotic process involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "activation of apoptotic process involved in development" NARROW [GOC:TermGenie] synonym: "activation of apoptotic process involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "activation of apoptotic program involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "activation of apoptotic program involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "activation of apoptotic programmed cell death involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "activation of apoptotic programmed cell death involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "activation of commitment to apoptosis involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "activation of commitment to apoptosis involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "activation of induction of apoptosis by p53 involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "activation of induction of apoptosis by p53 involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "activation of induction of apoptosis involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "activation of induction of apoptosis involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "activation of programmed cell death by apoptosis involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "activation of programmed cell death by apoptosis involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "activation of signaling (initiator) caspase activity involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "activation of signaling (initiator) caspase activity involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "activation of type I programmed cell death involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "activation of type I programmed cell death involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "positive regulation of activation of apoptosis involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "positive regulation of activation of apoptosis involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "positive regulation of apoptosis activator activity involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "positive regulation of apoptosis activator activity involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "positive regulation of apoptosis involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "positive regulation of apoptosis involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "positive regulation of apoptosis signaling involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "positive regulation of apoptosis signaling involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "positive regulation of apoptotic cell death involved in anatomical structure development" EXACT [GOC:TermGenie] synonym: "positive regulation of apoptotic cell death involved in development of an anatomical structure" EXACT [GOC:TermGenie] synonym: "positive regulation of apoptotic process involved in anatomical structure development" EXACT [GOC:TermGenie] synonym: "positive regulation of apoptotic process involved in development of an anatomical structure" EXACT [GOC:TermGenie] synonym: "positive regulation of apoptotic program involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "positive regulation of apoptotic program involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "positive regulation of apoptotic programmed cell death involved in anatomical structure development" EXACT [GOC:TermGenie] synonym: "positive regulation of apoptotic programmed cell death involved in development of an anatomical structure" EXACT [GOC:TermGenie] synonym: "positive regulation of commitment to apoptosis involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "positive regulation of commitment to apoptosis involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "positive regulation of induction of apoptosis by p53 involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "positive regulation of induction of apoptosis by p53 involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "positive regulation of induction of apoptosis involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "positive regulation of induction of apoptosis involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "positive regulation of programmed cell death by apoptosis involved in anatomical structure development" EXACT [GOC:TermGenie] synonym: "positive regulation of programmed cell death by apoptosis involved in development of an anatomical structure" EXACT [GOC:TermGenie] synonym: "positive regulation of signaling (initiator) caspase activity involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "positive regulation of signaling (initiator) caspase activity involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "positive regulation of type I programmed cell death involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "positive regulation of type I programmed cell death involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "up regulation of activation of apoptosis involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "up regulation of activation of apoptosis involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "up regulation of apoptosis activator activity involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "up regulation of apoptosis activator activity involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "up regulation of apoptosis involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "up regulation of apoptosis involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "up regulation of apoptosis signaling involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "up regulation of apoptosis signaling involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "up regulation of apoptotic cell death involved in anatomical structure development" EXACT [GOC:TermGenie] synonym: "up regulation of apoptotic cell death involved in development of an anatomical structure" EXACT [GOC:TermGenie] synonym: "up regulation of apoptotic process involved in anatomical structure development" EXACT [GOC:TermGenie] synonym: "up regulation of apoptotic process involved in development" EXACT [GOC:TermGenie] synonym: "up regulation of apoptotic process involved in development of an anatomical structure" EXACT [GOC:TermGenie] synonym: "up regulation of apoptotic program involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "up regulation of apoptotic program involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "up regulation of apoptotic programmed cell death involved in anatomical structure development" EXACT [GOC:TermGenie] synonym: "up regulation of apoptotic programmed cell death involved in development of an anatomical structure" EXACT [GOC:TermGenie] synonym: "up regulation of commitment to apoptosis involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "up regulation of commitment to apoptosis involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "up regulation of induction of apoptosis by p53 involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "up regulation of induction of apoptosis by p53 involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "up regulation of induction of apoptosis involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "up regulation of induction of apoptosis involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "up regulation of programmed cell death by apoptosis involved in anatomical structure development" EXACT [GOC:TermGenie] synonym: "up regulation of programmed cell death by apoptosis involved in development of an anatomical structure" EXACT [GOC:TermGenie] synonym: "up regulation of signaling (initiator) caspase activity involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "up regulation of signaling (initiator) caspase activity involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "up regulation of type I programmed cell death involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "up regulation of type I programmed cell death involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "up-regulation of activation of apoptosis involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "up-regulation of activation of apoptosis involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "up-regulation of apoptosis activator activity involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "up-regulation of apoptosis activator activity involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "up-regulation of apoptosis involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "up-regulation of apoptosis involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "up-regulation of apoptosis signaling involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "up-regulation of apoptosis signaling involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "up-regulation of apoptotic cell death involved in anatomical structure development" EXACT [GOC:TermGenie] synonym: "up-regulation of apoptotic cell death involved in development of an anatomical structure" EXACT [GOC:TermGenie] synonym: "up-regulation of apoptotic process involved in anatomical structure development" EXACT [GOC:TermGenie] synonym: "up-regulation of apoptotic process involved in development" EXACT [GOC:TermGenie] synonym: "up-regulation of apoptotic process involved in development of an anatomical structure" EXACT [GOC:TermGenie] synonym: "up-regulation of apoptotic program involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "up-regulation of apoptotic program involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "up-regulation of apoptotic programmed cell death involved in anatomical structure development" EXACT [GOC:TermGenie] synonym: "up-regulation of apoptotic programmed cell death involved in development of an anatomical structure" EXACT [GOC:TermGenie] synonym: "up-regulation of commitment to apoptosis involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "up-regulation of commitment to apoptosis involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "up-regulation of induction of apoptosis by p53 involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "up-regulation of induction of apoptosis by p53 involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "up-regulation of induction of apoptosis involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "up-regulation of induction of apoptosis involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "up-regulation of programmed cell death by apoptosis involved in anatomical structure development" EXACT [GOC:TermGenie] synonym: "up-regulation of programmed cell death by apoptosis involved in development of an anatomical structure" EXACT [GOC:TermGenie] synonym: "up-regulation of signaling (initiator) caspase activity involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "up-regulation of signaling (initiator) caspase activity involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "up-regulation of type I programmed cell death involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "up-regulation of type I programmed cell death involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "upregulation of activation of apoptosis involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "upregulation of activation of apoptosis involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "upregulation of apoptosis activator activity involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "upregulation of apoptosis activator activity involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "upregulation of apoptosis involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "upregulation of apoptosis involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "upregulation of apoptosis signaling involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "upregulation of apoptosis signaling involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "upregulation of apoptotic cell death involved in anatomical structure development" EXACT [GOC:TermGenie] synonym: "upregulation of apoptotic cell death involved in development of an anatomical structure" EXACT [GOC:TermGenie] synonym: "upregulation of apoptotic process involved in anatomical structure development" EXACT [GOC:TermGenie] synonym: "upregulation of apoptotic process involved in development" EXACT [GOC:TermGenie] synonym: "upregulation of apoptotic process involved in development of an anatomical structure" EXACT [GOC:TermGenie] synonym: "upregulation of apoptotic program involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "upregulation of apoptotic program involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "upregulation of apoptotic programmed cell death involved in anatomical structure development" EXACT [GOC:TermGenie] synonym: "upregulation of apoptotic programmed cell death involved in development of an anatomical structure" EXACT [GOC:TermGenie] synonym: "upregulation of commitment to apoptosis involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "upregulation of commitment to apoptosis involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "upregulation of induction of apoptosis by p53 involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "upregulation of induction of apoptosis by p53 involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "upregulation of induction of apoptosis involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "upregulation of induction of apoptosis involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "upregulation of programmed cell death by apoptosis involved in anatomical structure development" EXACT [GOC:TermGenie] synonym: "upregulation of programmed cell death by apoptosis involved in development of an anatomical structure" EXACT [GOC:TermGenie] synonym: "upregulation of signaling (initiator) caspase activity involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "upregulation of signaling (initiator) caspase activity involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "upregulation of type I programmed cell death involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "upregulation of type I programmed cell death involved in development of an anatomical structure" NARROW [GOC:TermGenie] is_a: GO:0043065 ! positive regulation of apoptotic process is_a: GO:0051094 ! positive regulation of developmental process is_a: GO:1904748 ! regulation of apoptotic process involved in development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:1902742 ! positively regulates apoptotic process involved in development relationship: RO:0002213 GO:1902742 ! positively regulates apoptotic process involved in development property_value: RO:0002161 NCBITaxon:4896 creation_date: 2015-10-19T14:12:34Z [Term] id: GO:1904748 name: regulation of apoptotic process involved in development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of apoptotic process involved in development." [GO_REF:0000058, GOC:TermGenie, PMID:22801495] comment: Q10943 in PMID:22801495, inferred from mutant phenotype synonym: "regulation of activation of apoptosis involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "regulation of activation of apoptosis involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "regulation of apoptosis activator activity involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "regulation of apoptosis activator activity involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "regulation of apoptosis involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "regulation of apoptosis involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "regulation of apoptosis signaling involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "regulation of apoptosis signaling involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "regulation of apoptotic cell death involved in anatomical structure development" EXACT [GOC:TermGenie] synonym: "regulation of apoptotic cell death involved in development of an anatomical structure" EXACT [GOC:TermGenie] synonym: "regulation of apoptotic process involved in anatomical structure development" EXACT [GOC:TermGenie] synonym: "regulation of apoptotic process involved in development of an anatomical structure" EXACT [GOC:TermGenie] synonym: "regulation of apoptotic program involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "regulation of apoptotic program involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "regulation of apoptotic programmed cell death involved in anatomical structure development" EXACT [GOC:TermGenie] synonym: "regulation of apoptotic programmed cell death involved in development of an anatomical structure" EXACT [GOC:TermGenie] synonym: "regulation of commitment to apoptosis involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "regulation of commitment to apoptosis involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "regulation of induction of apoptosis by p53 involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "regulation of induction of apoptosis by p53 involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "regulation of induction of apoptosis involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "regulation of induction of apoptosis involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "regulation of programmed cell death by apoptosis involved in anatomical structure development" EXACT [GOC:TermGenie] synonym: "regulation of programmed cell death by apoptosis involved in development of an anatomical structure" EXACT [GOC:TermGenie] synonym: "regulation of signaling (initiator) caspase activity involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "regulation of signaling (initiator) caspase activity involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "regulation of type I programmed cell death involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "regulation of type I programmed cell death involved in development of an anatomical structure" NARROW [GOC:TermGenie] is_a: GO:0042981 ! regulation of apoptotic process is_a: GO:0050793 ! regulation of developmental process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:1902742 ! regulates apoptotic process involved in development relationship: RO:0002211 GO:1902742 ! regulates apoptotic process involved in development property_value: RO:0002161 NCBITaxon:4896 creation_date: 2015-10-19T15:02:28Z [Term] id: GO:1904749 name: regulation of protein localization to nucleolus namespace: biological_process def: "Any process that modulates the frequency, rate or extent of protein localization to nucleolus." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:24415760] synonym: "regulation of protein localisation in nucleolus" EXACT [GOC:TermGenie] synonym: "regulation of protein localisation to nucleolus" EXACT [GOC:TermGenie] synonym: "regulation of protein localization in nucleolus" EXACT [GOC:TermGenie] is_a: GO:1900180 ! regulation of protein localization to nucleus intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:1902570 ! regulates protein localization to nucleolus relationship: RO:0002211 GO:1902570 ! regulates protein localization to nucleolus creation_date: 2015-10-19T15:16:17Z [Term] id: GO:1904750 name: negative regulation of protein localization to nucleolus namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to nucleolus." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:24415760] synonym: "down regulation of protein localisation in nucleolus" EXACT [GOC:TermGenie] synonym: "down regulation of protein localisation to nucleolus" EXACT [GOC:TermGenie] synonym: "down regulation of protein localization in nucleolus" EXACT [GOC:TermGenie] synonym: "down regulation of protein localization to nucleolus" EXACT [GOC:TermGenie] synonym: "down-regulation of protein localisation in nucleolus" EXACT [GOC:TermGenie] synonym: "down-regulation of protein localisation to nucleolus" EXACT [GOC:TermGenie] synonym: "down-regulation of protein localization in nucleolus" EXACT [GOC:TermGenie] synonym: "down-regulation of protein localization to nucleolus" EXACT [GOC:TermGenie] synonym: "downregulation of protein localisation in nucleolus" EXACT [GOC:TermGenie] synonym: "downregulation of protein localisation to nucleolus" EXACT [GOC:TermGenie] synonym: "downregulation of protein localization in nucleolus" EXACT [GOC:TermGenie] synonym: "downregulation of protein localization to nucleolus" EXACT [GOC:TermGenie] synonym: "inhibition of protein localisation in nucleolus" NARROW [GOC:TermGenie] synonym: "inhibition of protein localisation to nucleolus" NARROW [GOC:TermGenie] synonym: "inhibition of protein localization in nucleolus" NARROW [GOC:TermGenie] synonym: "inhibition of protein localization to nucleolus" NARROW [GOC:TermGenie] synonym: "negative regulation of protein localisation in nucleolus" EXACT [GOC:TermGenie] synonym: "negative regulation of protein localisation to nucleolus" EXACT [GOC:TermGenie] synonym: "negative regulation of protein localization in nucleolus" EXACT [GOC:TermGenie] is_a: GO:1900181 ! negative regulation of protein localization to nucleus is_a: GO:1904749 ! regulation of protein localization to nucleolus intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:1902570 ! negatively regulates protein localization to nucleolus relationship: RO:0002212 GO:1902570 ! negatively regulates protein localization to nucleolus creation_date: 2015-10-19T15:16:24Z [Term] id: GO:1904751 name: positive regulation of protein localization to nucleolus namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of protein localization to nucleolus." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:24415760] synonym: "activation of protein localisation in nucleolus" NARROW [GOC:TermGenie] synonym: "activation of protein localisation to nucleolus" NARROW [GOC:TermGenie] synonym: "activation of protein localization in nucleolus" NARROW [GOC:TermGenie] synonym: "activation of protein localization to nucleolus" NARROW [GOC:TermGenie] synonym: "positive regulation of protein localisation in nucleolus" EXACT [GOC:TermGenie] synonym: "positive regulation of protein localisation to nucleolus" EXACT [GOC:TermGenie] synonym: "positive regulation of protein localization in nucleolus" EXACT [GOC:TermGenie] synonym: "up regulation of protein localisation in nucleolus" EXACT [GOC:TermGenie] synonym: "up regulation of protein localisation to nucleolus" EXACT [GOC:TermGenie] synonym: "up regulation of protein localization in nucleolus" EXACT [GOC:TermGenie] synonym: "up regulation of protein localization to nucleolus" EXACT [GOC:TermGenie] synonym: "up-regulation of protein localisation in nucleolus" EXACT [GOC:TermGenie] synonym: "up-regulation of protein localisation to nucleolus" EXACT [GOC:TermGenie] synonym: "up-regulation of protein localization in nucleolus" EXACT [GOC:TermGenie] synonym: "up-regulation of protein localization to nucleolus" EXACT [GOC:TermGenie] synonym: "upregulation of protein localisation in nucleolus" EXACT [GOC:TermGenie] synonym: "upregulation of protein localisation to nucleolus" EXACT [GOC:TermGenie] synonym: "upregulation of protein localization in nucleolus" EXACT [GOC:TermGenie] synonym: "upregulation of protein localization to nucleolus" EXACT [GOC:TermGenie] is_a: GO:1900182 ! positive regulation of protein localization to nucleus is_a: GO:1904749 ! regulation of protein localization to nucleolus intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:1902570 ! positively regulates protein localization to nucleolus relationship: RO:0002213 GO:1902570 ! positively regulates protein localization to nucleolus creation_date: 2015-10-19T15:16:30Z [Term] id: GO:1904752 name: regulation of vascular associated smooth muscle cell migration namespace: biological_process def: "Any process that modulates the frequency, rate or extent of vascular associated smooth muscle cell migration." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:20693317] synonym: "regulation of vascular smooth muscle cell migration" EXACT [GOC:TermGenie] is_a: GO:0014910 ! regulation of smooth muscle cell migration intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:1904738 ! regulates vascular associated smooth muscle cell migration relationship: RO:0002211 GO:1904738 ! regulates vascular associated smooth muscle cell migration property_value: RO:0002161 NCBITaxon:451864 creation_date: 2015-10-19T15:49:52Z [Term] id: GO:1904753 name: negative regulation of vascular associated smooth muscle cell migration namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of vascular associated smooth muscle cell migration." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:20693317] synonym: "down regulation of vascular associated smooth muscle cell migration" EXACT [GOC:TermGenie] synonym: "down regulation of vascular smooth muscle cell migration" EXACT [GOC:TermGenie] synonym: "down-regulation of vascular associated smooth muscle cell migration" EXACT [GOC:TermGenie] synonym: "down-regulation of vascular smooth muscle cell migration" EXACT [GOC:TermGenie] synonym: "downregulation of vascular associated smooth muscle cell migration" EXACT [GOC:TermGenie] synonym: "downregulation of vascular smooth muscle cell migration" EXACT [GOC:TermGenie] synonym: "inhibition of vascular associated smooth muscle cell migration" NARROW [GOC:TermGenie] synonym: "inhibition of vascular smooth muscle cell migration" NARROW [GOC:TermGenie] synonym: "negative regulation of vascular smooth muscle cell migration" EXACT [GOC:TermGenie] is_a: GO:0014912 ! negative regulation of smooth muscle cell migration is_a: GO:1904752 ! regulation of vascular associated smooth muscle cell migration intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:1904738 ! negatively regulates vascular associated smooth muscle cell migration relationship: RO:0002212 GO:1904738 ! negatively regulates vascular associated smooth muscle cell migration property_value: RO:0002161 NCBITaxon:451864 creation_date: 2015-10-19T15:49:58Z [Term] id: GO:1904754 name: positive regulation of vascular associated smooth muscle cell migration namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of vascular associated smooth muscle cell migration." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:20693317] synonym: "activation of vascular associated smooth muscle cell migration" NARROW [GOC:TermGenie] synonym: "activation of vascular smooth muscle cell migration" NARROW [GOC:TermGenie] synonym: "positive regulation of vascular smooth muscle cell migration" EXACT [GOC:TermGenie] synonym: "up regulation of vascular associated smooth muscle cell migration" EXACT [GOC:TermGenie] synonym: "up regulation of vascular smooth muscle cell migration" EXACT [GOC:TermGenie] synonym: "up-regulation of vascular associated smooth muscle cell migration" EXACT [GOC:TermGenie] synonym: "up-regulation of vascular smooth muscle cell migration" EXACT [GOC:TermGenie] synonym: "upregulation of vascular associated smooth muscle cell migration" EXACT [GOC:TermGenie] synonym: "upregulation of vascular smooth muscle cell migration" EXACT [GOC:TermGenie] is_a: GO:0014911 ! positive regulation of smooth muscle cell migration is_a: GO:1904752 ! regulation of vascular associated smooth muscle cell migration intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:1904738 ! positively regulates vascular associated smooth muscle cell migration relationship: RO:0002213 GO:1904738 ! positively regulates vascular associated smooth muscle cell migration property_value: RO:0002161 NCBITaxon:451864 creation_date: 2015-10-19T15:50:05Z [Term] id: GO:1904760 name: regulation of myofibroblast differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of myofibroblast differentiation." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:20533548] synonym: "regulation of myofibroblast cell differentiation" EXACT [GOC:TermGenie] is_a: GO:0045595 ! regulation of cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0036446 ! regulates myofibroblast differentiation relationship: RO:0002211 GO:0036446 ! regulates myofibroblast differentiation creation_date: 2015-10-23T12:15:05Z [Term] id: GO:1904761 name: negative regulation of myofibroblast differentiation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of myofibroblast differentiation." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:20533548] synonym: "down regulation of myofibroblast cell differentiation" EXACT [GOC:TermGenie] synonym: "down regulation of myofibroblast differentiation" EXACT [GOC:TermGenie] synonym: "down-regulation of myofibroblast cell differentiation" EXACT [GOC:TermGenie] synonym: "down-regulation of myofibroblast differentiation" EXACT [GOC:TermGenie] synonym: "downregulation of myofibroblast cell differentiation" EXACT [GOC:TermGenie] synonym: "downregulation of myofibroblast differentiation" EXACT [GOC:TermGenie] synonym: "inhibition of myofibroblast cell differentiation" NARROW [GOC:TermGenie] synonym: "inhibition of myofibroblast differentiation" NARROW [GOC:TermGenie] synonym: "negative regulation of myofibroblast cell differentiation" EXACT [GOC:TermGenie] is_a: GO:0045596 ! negative regulation of cell differentiation is_a: GO:1904760 ! regulation of myofibroblast differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0036446 ! negatively regulates myofibroblast differentiation relationship: RO:0002212 GO:0036446 ! negatively regulates myofibroblast differentiation creation_date: 2015-10-23T12:15:11Z [Term] id: GO:1904762 name: positive regulation of myofibroblast differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of myofibroblast differentiation." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:20533548] synonym: "activation of myofibroblast cell differentiation" NARROW [GOC:TermGenie] synonym: "activation of myofibroblast differentiation" NARROW [GOC:TermGenie] synonym: "positive regulation of myofibroblast cell differentiation" EXACT [GOC:TermGenie] synonym: "up regulation of myofibroblast cell differentiation" EXACT [GOC:TermGenie] synonym: "up regulation of myofibroblast differentiation" EXACT [GOC:TermGenie] synonym: "up-regulation of myofibroblast cell differentiation" EXACT [GOC:TermGenie] synonym: "up-regulation of myofibroblast differentiation" EXACT [GOC:TermGenie] synonym: "upregulation of myofibroblast cell differentiation" EXACT [GOC:TermGenie] synonym: "upregulation of myofibroblast differentiation" EXACT [GOC:TermGenie] is_a: GO:0045597 ! positive regulation of cell differentiation is_a: GO:1904760 ! regulation of myofibroblast differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0036446 ! positively regulates myofibroblast differentiation relationship: RO:0002213 GO:0036446 ! positively regulates myofibroblast differentiation creation_date: 2015-10-23T12:15:17Z [Term] id: GO:1904770 name: intramembranous bone morphogenesis namespace: biological_process def: "The developmental process by which an intramembranous bone is generated and organized." [GO_REF:0000083, GOC:TermGenie, PMID:26399686] synonym: "intramembranous bones morphogenesis" RELATED [GOC:TermGenie] synonym: "membrane bone morphogenesis" RELATED [GOC:TermGenie] is_a: GO:0060349 ! bone morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0002514 ! results in morphogenesis of intramembranous bone relationship: RO:0002298 UBERON:0002514 ! results in morphogenesis of intramembranous bone creation_date: 2015-10-28T11:46:04Z [Term] id: GO:1904776 name: regulation of protein localization to cell cortex namespace: biological_process def: "Any process that modulates the frequency, rate or extent of protein localization to cell cortex." [GO_REF:0000058, GOC:TermGenie, PMID:17115027] comment: An example is cye-1 in C. elegans, UniProt ID O01501 in PMID:17115027. synonym: "regulation of protein localisation to cell cortex" EXACT [GOC:TermGenie] is_a: GO:1904375 ! regulation of protein localization to cell periphery intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0072697 ! regulates protein localization to cell cortex relationship: RO:0002211 GO:0072697 ! regulates protein localization to cell cortex creation_date: 2015-10-29T16:55:01Z [Term] id: GO:1904777 name: negative regulation of protein localization to cell cortex namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to cell cortex." [GO_REF:0000058, GOC:TermGenie, PMID:17115027] comment: An example is cye-1 in C. elegans, UniProt ID O01501 in PMID:17115027. synonym: "down regulation of protein localisation to cell cortex" EXACT [GOC:TermGenie] synonym: "down regulation of protein localization to cell cortex" EXACT [GOC:TermGenie] synonym: "down-regulation of protein localisation to cell cortex" EXACT [GOC:TermGenie] synonym: "down-regulation of protein localization to cell cortex" EXACT [GOC:TermGenie] synonym: "downregulation of protein localisation to cell cortex" EXACT [GOC:TermGenie] synonym: "downregulation of protein localization to cell cortex" EXACT [GOC:TermGenie] synonym: "inhibition of protein localisation to cell cortex" NARROW [GOC:TermGenie] synonym: "inhibition of protein localization to cell cortex" NARROW [GOC:TermGenie] synonym: "negative regulation of protein localisation to cell cortex" EXACT [GOC:TermGenie] is_a: GO:1904376 ! negative regulation of protein localization to cell periphery is_a: GO:1904776 ! regulation of protein localization to cell cortex intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0072697 ! negatively regulates protein localization to cell cortex relationship: RO:0002212 GO:0072697 ! negatively regulates protein localization to cell cortex creation_date: 2015-10-29T16:55:08Z [Term] id: GO:1904778 name: positive regulation of protein localization to cell cortex namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of protein localization to cell cortex." [GO_REF:0000058, GOC:TermGenie, PMID:17115027] comment: An example is cye-1 in C. elegans, UniProt ID O01501 in PMID:17115027. synonym: "activation of protein localisation to cell cortex" NARROW [GOC:TermGenie] synonym: "activation of protein localization to cell cortex" NARROW [GOC:TermGenie] synonym: "positive regulation of protein localisation to cell cortex" EXACT [GOC:TermGenie] synonym: "up regulation of protein localisation to cell cortex" EXACT [GOC:TermGenie] synonym: "up regulation of protein localization to cell cortex" EXACT [GOC:TermGenie] synonym: "up-regulation of protein localisation to cell cortex" EXACT [GOC:TermGenie] synonym: "up-regulation of protein localization to cell cortex" EXACT [GOC:TermGenie] synonym: "upregulation of protein localisation to cell cortex" EXACT [GOC:TermGenie] synonym: "upregulation of protein localization to cell cortex" EXACT [GOC:TermGenie] is_a: GO:1904377 ! positive regulation of protein localization to cell periphery is_a: GO:1904776 ! regulation of protein localization to cell cortex intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0072697 ! positively regulates protein localization to cell cortex relationship: RO:0002213 GO:0072697 ! positively regulates protein localization to cell cortex creation_date: 2015-10-29T16:55:15Z [Term] id: GO:1904809 name: regulation of dense core granule transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of dense core granule transport." [GO_REF:0000058, GOC:TermGenie, PMID:22699897] comment: cdk-5 in C.elegans (G5ECH7) in PMID:22699897 (inferred from mutant phenotype). synonym: "regulation of dense core vesicle transport" EXACT [GOC:TermGenie] is_a: GO:0032386 ! regulation of intracellular transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:1901950 ! regulates dense core granule transport relationship: RO:0002211 GO:1901950 ! regulates dense core granule transport creation_date: 2015-11-11T10:40:10Z [Term] id: GO:1904810 name: negative regulation of dense core granule transport namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of dense core granule transport." [GO_REF:0000058, GOC:TermGenie, PMID:22699897] comment: cdk-5 in C.elegans (G5ECH7) in PMID:22699897 (inferred from mutant phenotype). synonym: "down regulation of dense core granule transport" EXACT [GOC:TermGenie] synonym: "down regulation of dense core vesicle transport" EXACT [GOC:TermGenie] synonym: "down-regulation of dense core granule transport" EXACT [GOC:TermGenie] synonym: "down-regulation of dense core vesicle transport" EXACT [GOC:TermGenie] synonym: "downregulation of dense core granule transport" EXACT [GOC:TermGenie] synonym: "downregulation of dense core vesicle transport" EXACT [GOC:TermGenie] synonym: "inhibition of dense core granule transport" NARROW [GOC:TermGenie] synonym: "inhibition of dense core vesicle transport" NARROW [GOC:TermGenie] synonym: "negative regulation of dense core vesicle transport" EXACT [GOC:TermGenie] is_a: GO:0032387 ! negative regulation of intracellular transport is_a: GO:1904809 ! regulation of dense core granule transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:1901950 ! negatively regulates dense core granule transport relationship: RO:0002212 GO:1901950 ! negatively regulates dense core granule transport creation_date: 2015-11-11T10:40:18Z [Term] id: GO:1904811 name: positive regulation of dense core granule transport namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of dense core granule transport." [GO_REF:0000058, GOC:TermGenie, PMID:22699897] comment: cdk-5 in C.elegans (G5ECH7) in PMID:22699897 (inferred from mutant phenotype). synonym: "activation of dense core granule transport" NARROW [GOC:TermGenie] synonym: "activation of dense core vesicle transport" NARROW [GOC:TermGenie] synonym: "positive regulation of dense core vesicle transport" EXACT [GOC:TermGenie] synonym: "up regulation of dense core granule transport" EXACT [GOC:TermGenie] synonym: "up regulation of dense core vesicle transport" EXACT [GOC:TermGenie] synonym: "up-regulation of dense core granule transport" EXACT [GOC:TermGenie] synonym: "up-regulation of dense core vesicle transport" EXACT [GOC:TermGenie] synonym: "upregulation of dense core granule transport" EXACT [GOC:TermGenie] synonym: "upregulation of dense core vesicle transport" EXACT [GOC:TermGenie] is_a: GO:0032388 ! positive regulation of intracellular transport is_a: GO:1904809 ! regulation of dense core granule transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:1901950 ! positively regulates dense core granule transport relationship: RO:0002213 GO:1901950 ! positively regulates dense core granule transport creation_date: 2015-11-11T10:40:25Z [Term] id: GO:1904817 name: serous membrane development namespace: biological_process def: "The process whose specific outcome is the progression of a serous membrane over time, from its formation to the mature structure." [GO_REF:0000094, GOC:dph, GOC:TermGenie, PMID:15840053] synonym: "serosa development" RELATED [GOC:TermGenie] synonym: "tunica serosa development" EXACT [GOC:TermGenie] synonym: "wall of serous sac development" EXACT [GOC:TermGenie] is_a: GO:0048856 ! anatomical structure development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0000042 ! results in development of serous membrane relationship: RO:0002296 UBERON:0000042 ! results in development of serous membrane creation_date: 2015-11-17T19:00:01Z [Term] id: GO:1904818 name: visceral peritoneum development namespace: biological_process def: "The process whose specific outcome is the progression of a visceral peritoneum over time, from its formation to the mature structure." [GO_REF:0000094, GOC:dph, GOC:TermGenie, PMID:15840053] is_a: GO:0048856 ! anatomical structure development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0001178 ! results in development of visceral peritoneum relationship: BFO:0000050 GO:1904820 ! part of peritoneum development relationship: RO:0002296 UBERON:0001178 ! results in development of visceral peritoneum creation_date: 2015-11-17T19:00:17Z [Term] id: GO:1904819 name: parietal peritoneum development namespace: biological_process def: "The process whose specific outcome is the progression of a parietal peritoneum over time, from its formation to the mature structure." [GO_REF:0000094, GOC:dph, GOC:TermGenie, PMID:15840053] synonym: "peritoneal cavity lining development" EXACT [GOC:TermGenie] is_a: GO:0048856 ! anatomical structure development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0001366 ! results in development of parietal peritoneum relationship: BFO:0000050 GO:1904820 ! part of peritoneum development relationship: RO:0002296 UBERON:0001366 ! results in development of parietal peritoneum creation_date: 2015-11-17T19:00:24Z [Term] id: GO:1904820 name: peritoneum development namespace: biological_process def: "The process whose specific outcome is the progression of a peritoneum over time, from its formation to the mature structure." [GO_REF:0000094, GOC:dph, GOC:TermGenie, PMID:15840053] synonym: "peritonaeum development" RELATED [GOC:TermGenie] is_a: GO:1904817 ! serous membrane development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0002358 ! results in development of peritoneum relationship: RO:0002296 UBERON:0002358 ! results in development of peritoneum creation_date: 2015-11-18T17:23:51Z [Term] id: GO:1904821 name: chloroplast disassembly namespace: biological_process def: "The disaggregation of a chloroplast into its constituent components." [GO_REF:0000079, GOC:TermGenie, PMID:26494759] comment: The disaggregation of a chloroplast into its constituent components. synonym: "chloroplast degradation" RELATED [PMID:26494759] is_a: GO:0009658 ! chloroplast organization is_a: GO:1903008 ! organelle disassembly intersection_of: GO:0022411 ! cellular component disassembly intersection_of: RO:0002590 GO:0009507 ! results in disassembly of chloroplast relationship: RO:0002590 GO:0009507 ! results in disassembly of chloroplast property_value: RO:0002161 NCBITaxon:28009 property_value: RO:0002161 NCBITaxon:33208 property_value: RO:0002161 NCBITaxon:4751 property_value: RO:0002161 NCBITaxon:554915 creation_date: 2015-11-19T00:41:18Z [Term] id: GO:1904829 name: regulation of aortic smooth muscle cell differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of aortic smooth muscle cell differentiation." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:22034194] is_a: GO:1905063 ! regulation of vascular associated smooth muscle cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0035887 ! regulates aortic smooth muscle cell differentiation relationship: RO:0002211 GO:0035887 ! regulates aortic smooth muscle cell differentiation creation_date: 2015-11-24T10:20:40Z [Term] id: GO:1904830 name: negative regulation of aortic smooth muscle cell differentiation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of aortic smooth muscle cell differentiation." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:22034194] synonym: "down regulation of aortic smooth muscle cell differentiation" EXACT [GOC:TermGenie] synonym: "down-regulation of aortic smooth muscle cell differentiation" EXACT [GOC:TermGenie] synonym: "downregulation of aortic smooth muscle cell differentiation" EXACT [GOC:TermGenie] synonym: "inhibition of aortic smooth muscle cell differentiation" NARROW [GOC:TermGenie] is_a: GO:1904829 ! regulation of aortic smooth muscle cell differentiation is_a: GO:1905064 ! negative regulation of vascular associated smooth muscle cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0035887 ! negatively regulates aortic smooth muscle cell differentiation relationship: RO:0002212 GO:0035887 ! negatively regulates aortic smooth muscle cell differentiation creation_date: 2015-11-24T10:20:47Z [Term] id: GO:1904831 name: positive regulation of aortic smooth muscle cell differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of aortic smooth muscle cell differentiation." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:22034194] synonym: "activation of aortic smooth muscle cell differentiation" NARROW [GOC:TermGenie] synonym: "up regulation of aortic smooth muscle cell differentiation" EXACT [GOC:TermGenie] synonym: "up-regulation of aortic smooth muscle cell differentiation" EXACT [GOC:TermGenie] synonym: "upregulation of aortic smooth muscle cell differentiation" EXACT [GOC:TermGenie] is_a: GO:1904829 ! regulation of aortic smooth muscle cell differentiation is_a: GO:1905065 ! positive regulation of vascular associated smooth muscle cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0035887 ! positively regulates aortic smooth muscle cell differentiation relationship: RO:0002213 GO:0035887 ! positively regulates aortic smooth muscle cell differentiation creation_date: 2015-11-24T10:20:54Z [Term] id: GO:1904835 name: dorsal root ganglion morphogenesis namespace: biological_process def: "The developmental process by which a dorsal root ganglion is generated and organized." [GO_REF:0000083, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:18936100] synonym: "dorsal root ganglia morphogenesis" RELATED [GOC:TermGenie] synonym: "DRG morphogenesis" RELATED [GOC:TermGenie] synonym: "ganglion of dorsal root morphogenesis" EXACT [GOC:TermGenie] synonym: "ganglion sensorium nervi spinalis morphogenesis" RELATED [GOC:TermGenie] synonym: "ganglion spinale morphogenesis" RELATED [GOC:TermGenie] synonym: "ganglion spinalis morphogenesis" EXACT [GOC:TermGenie] synonym: "posterior root ganglion morphogenesis" RELATED [GOC:TermGenie] synonym: "spinal ganglion morphogenesis" EXACT [GOC:TermGenie] synonym: "spinal ganglion part of peripheral nervous system morphogenesis" EXACT [GOC:TermGenie] is_a: GO:0061552 ! ganglion morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0000044 ! results in morphogenesis of dorsal root ganglion relationship: BFO:0000050 GO:1990791 ! part of dorsal root ganglion development relationship: RO:0002298 UBERON:0000044 ! results in morphogenesis of dorsal root ganglion creation_date: 2015-12-01T16:41:17Z [Term] id: GO:1904836 name: facioacoustic ganglion morphogenesis namespace: biological_process def: "The developmental process by which an acoustico-facial VII-VIII ganglion complex is generated and organized." [GO_REF:0000083, GOC:bf, GOC:mat, GOC:PARL, GOC:TermGenie, PMID:18356247] synonym: "acoustico-facial VII-VIII ganglion complex morphogenesis" EXACT [UBERON:0012175] synonym: "acousticofacial ganglion morphogenesis" EXACT [GOC:TermGenie] synonym: "facio-acoustic ganglion complex morphogenesis" RELATED [GOC:TermGenie] synonym: "facio-acoustic ganglion complex VII-VIII morphogenesis" EXACT [GOC:TermGenie] synonym: "facio-acoustic ganglion morphogenesis" EXACT [GOC:TermGenie] synonym: "facio-acoustic VII-VIII ganglion complex morphogenesis" RELATED [GOC:TermGenie] is_a: GO:0061559 ! cranial ganglion morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0012175 ! results in morphogenesis of acoustico-facial VII-VIII ganglion complex relationship: BFO:0000050 GO:1903375 ! part of facioacoustic ganglion development relationship: RO:0002298 UBERON:0012175 ! results in morphogenesis of acoustico-facial VII-VIII ganglion complex creation_date: 2015-12-01T17:02:06Z [Term] id: GO:1904838 name: regulation of male germ-line stem cell asymmetric division namespace: biological_process def: "Any process that modulates the frequency, rate or extent of male germ-line stem cell asymmetric division." [GO_REF:0000058, GOC:TermGenie, PMID:19339709] synonym: "regulation of male germ-line stem cell renewal" EXACT [GOC:TermGenie] is_a: GO:0009786 ! regulation of asymmetric cell division is_a: GO:0051239 ! regulation of multicellular organismal process is_a: GO:2000035 ! regulation of stem cell division intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0048133 ! regulates male germ-line stem cell asymmetric division relationship: RO:0002211 GO:0048133 ! regulates male germ-line stem cell asymmetric division property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4751 creation_date: 2015-12-05T00:28:31Z [Term] id: GO:1904839 name: negative regulation of male germ-line stem cell asymmetric division namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of male germ-line stem cell asymmetric division." [GO_REF:0000058, GOC:TermGenie, PMID:19339709] synonym: "down regulation of male germ-line stem cell asymmetric division" EXACT [GOC:TermGenie] synonym: "down regulation of male germ-line stem cell renewal" EXACT [GOC:TermGenie] synonym: "down-regulation of male germ-line stem cell asymmetric division" EXACT [GOC:TermGenie] synonym: "down-regulation of male germ-line stem cell renewal" EXACT [GOC:TermGenie] synonym: "downregulation of male germ-line stem cell asymmetric division" EXACT [GOC:TermGenie] synonym: "downregulation of male germ-line stem cell renewal" EXACT [GOC:TermGenie] synonym: "inhibition of male germ-line stem cell asymmetric division" NARROW [GOC:TermGenie] synonym: "inhibition of male germ-line stem cell renewal" NARROW [GOC:TermGenie] synonym: "negative regulation of male germ-line stem cell renewal" EXACT [GOC:TermGenie] is_a: GO:0010721 ! negative regulation of cell development is_a: GO:0045769 ! negative regulation of asymmetric cell division is_a: GO:0051241 ! negative regulation of multicellular organismal process is_a: GO:1904838 ! regulation of male germ-line stem cell asymmetric division intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0048133 ! negatively regulates male germ-line stem cell asymmetric division relationship: RO:0002212 GO:0048133 ! negatively regulates male germ-line stem cell asymmetric division property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4751 creation_date: 2015-12-05T00:28:39Z [Term] id: GO:1904840 name: positive regulation of male germ-line stem cell asymmetric division namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of male germ-line stem cell asymmetric division." [GO_REF:0000058, GOC:TermGenie, PMID:19339709] synonym: "activation of male germ-line stem cell asymmetric division" NARROW [GOC:TermGenie] synonym: "activation of male germ-line stem cell renewal" NARROW [GOC:TermGenie] synonym: "positive regulation of male germ-line stem cell renewal" EXACT [GOC:TermGenie] synonym: "up regulation of male germ-line stem cell asymmetric division" EXACT [GOC:TermGenie] synonym: "up regulation of male germ-line stem cell renewal" EXACT [GOC:TermGenie] synonym: "up-regulation of male germ-line stem cell asymmetric division" EXACT [GOC:TermGenie] synonym: "up-regulation of male germ-line stem cell renewal" EXACT [GOC:TermGenie] synonym: "upregulation of male germ-line stem cell asymmetric division" EXACT [GOC:TermGenie] synonym: "upregulation of male germ-line stem cell renewal" EXACT [GOC:TermGenie] is_a: GO:0045770 ! positive regulation of asymmetric cell division is_a: GO:0051240 ! positive regulation of multicellular organismal process is_a: GO:1904838 ! regulation of male germ-line stem cell asymmetric division intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0048133 ! positively regulates male germ-line stem cell asymmetric division relationship: RO:0002213 GO:0048133 ! positively regulates male germ-line stem cell asymmetric division property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4751 creation_date: 2015-12-05T00:28:46Z [Term] id: GO:1904861 name: excitatory synapse assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form an excitatory synapse." [GO_REF:0000079, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:21670302] synonym: "excitatory synapse formation" EXACT [GOC:TermGenie] is_a: GO:0007416 ! synapse assembly intersection_of: GO:0009987 ! cellular process intersection_of: RO:0002588 GO:0060076 ! results in assembly of excitatory synapse relationship: RO:0002588 GO:0060076 ! results in assembly of excitatory synapse creation_date: 2015-12-17T10:31:26Z [Term] id: GO:1904866 name: ventral tegmental area development namespace: biological_process def: "The process whose specific outcome is the progression of a ventral tegmental area (VTA) over time, from its formation to the mature structure." [GO_REF:0000094, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:26548362] synonym: "a10a development" EXACT [GOC:TermGenie] synonym: "area tegmentalis ventralis (Tsai) development" RELATED [GOC:TermGenie] synonym: "area tegmentalis ventralis development" RELATED [GOC:TermGenie] synonym: "tegmentum ventrale development" RELATED [GOC:TermGenie] synonym: "ventral brain stem development" RELATED [GOC:TermGenie] synonym: "ventral tegmental area (Tsai) development" RELATED [GOC:TermGenie] synonym: "ventral tegmental area of tsai development" EXACT [GOC:TermGenie] synonym: "ventral tegmental nucleus (Rioch) development" RELATED [GOC:TermGenie] synonym: "ventral tegmental nucleus (tsai) development" EXACT [GOC:TermGenie] synonym: "ventral tegmental nucleus of tsai development" EXACT [GOC:TermGenie] synonym: "ventral tegmentum development" EXACT [Wikipedia:Ventral_tegmental_area] synonym: "ventromedial mesencephalic tegmentum development" RELATED [GOC:TermGenie] synonym: "VTA development" BROAD [GOC:TermGenie] is_a: GO:0048856 ! anatomical structure development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0002691 ! results in development of ventral tegmental area relationship: BFO:0000050 GO:0030901 ! part of midbrain development relationship: RO:0002296 UBERON:0002691 ! results in development of ventral tegmental area creation_date: 2015-12-17T14:44:18Z [Term] id: GO:1904888 name: cranial skeletal system development namespace: biological_process def: "The process whose specific outcome is the progression of a cranial skeletal system over time, from its formation to the mature structure. The cranial skeletal system is the skeletal subdivision of the head, and includes the skull (cranium plus mandible), pharyngeal and/or hyoid apparatus." [GO_REF:0000094, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:11262227] synonym: "cranial skeleton development" NARROW [GOC:TermGenie] synonym: "craniofacial development" NARROW [PMID:11262227] synonym: "cranium development" RELATED [GOC:TermGenie] synonym: "osteocranium development" NARROW [GOC:TermGenie] is_a: GO:0048856 ! anatomical structure development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0010323 ! results in development of cranial skeletal system relationship: RO:0002296 UBERON:0010323 ! results in development of cranial skeletal system creation_date: 2016-01-07T13:45:06Z [Term] id: GO:1904889 name: regulation of excitatory synapse assembly namespace: biological_process def: "Any process that modulates the frequency, rate or extent of excitatory synapse assembly." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie] synonym: "regulation of excitatory synapse formation" EXACT [GOC:TermGenie] is_a: GO:0051963 ! regulation of synapse assembly intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:1904861 ! regulates excitatory synapse assembly relationship: RO:0002211 GO:1904861 ! regulates excitatory synapse assembly creation_date: 2016-01-07T14:35:53Z [Term] id: GO:1904890 name: negative regulation of excitatory synapse assembly namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of excitatory synapse assembly." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie] synonym: "down regulation of excitatory synapse assembly" EXACT [GOC:TermGenie] synonym: "down regulation of excitatory synapse formation" EXACT [GOC:TermGenie] synonym: "down-regulation of excitatory synapse assembly" EXACT [GOC:TermGenie] synonym: "down-regulation of excitatory synapse formation" EXACT [GOC:TermGenie] synonym: "downregulation of excitatory synapse assembly" EXACT [GOC:TermGenie] synonym: "downregulation of excitatory synapse formation" EXACT [GOC:TermGenie] synonym: "inhibition of excitatory synapse assembly" NARROW [GOC:TermGenie] synonym: "inhibition of excitatory synapse formation" NARROW [GOC:TermGenie] synonym: "negative regulation of excitatory synapse formation" EXACT [GOC:TermGenie] is_a: GO:0051964 ! negative regulation of synapse assembly is_a: GO:1904889 ! regulation of excitatory synapse assembly intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:1904861 ! negatively regulates excitatory synapse assembly relationship: RO:0002212 GO:1904861 ! negatively regulates excitatory synapse assembly creation_date: 2016-01-07T14:36:00Z [Term] id: GO:1904891 name: positive regulation of excitatory synapse assembly namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of excitatory synapse assembly." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:21670302] synonym: "activation of excitatory synapse assembly" NARROW [GOC:TermGenie] synonym: "activation of excitatory synapse formation" NARROW [GOC:TermGenie] synonym: "positive regulation of excitatory synapse formation" EXACT [GOC:TermGenie] synonym: "up regulation of excitatory synapse assembly" EXACT [GOC:TermGenie] synonym: "up regulation of excitatory synapse formation" EXACT [GOC:TermGenie] synonym: "up-regulation of excitatory synapse assembly" EXACT [GOC:TermGenie] synonym: "up-regulation of excitatory synapse formation" EXACT [GOC:TermGenie] synonym: "upregulation of excitatory synapse assembly" EXACT [GOC:TermGenie] synonym: "upregulation of excitatory synapse formation" EXACT [GOC:TermGenie] is_a: GO:0051965 ! positive regulation of synapse assembly is_a: GO:1904889 ! regulation of excitatory synapse assembly intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:1904861 ! positively regulates excitatory synapse assembly relationship: RO:0002213 GO:1904861 ! positively regulates excitatory synapse assembly creation_date: 2016-01-07T14:36:07Z [Term] id: GO:1904897 name: regulation of hepatic stellate cell proliferation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of hepatic stellate cell proliferation." [GO_REF:0000058, GOC:TermGenie, PMID:15358192] synonym: "regulation of hepatic perisinusoidal cell proliferation" EXACT [GOC:TermGenie] synonym: "regulation of Ito cell proliferation" EXACT [GOC:TermGenie] synonym: "regulation of perisinusoidal cell proliferation" EXACT [GOC:TermGenie] is_a: GO:0048145 ! regulation of fibroblast proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:1990922 ! regulates hepatic stellate cell proliferation relationship: RO:0002211 GO:1990922 ! regulates hepatic stellate cell proliferation property_value: RO:0002161 NCBITaxon:4751 creation_date: 2016-01-14T15:56:59Z [Term] id: GO:1904898 name: negative regulation of hepatic stellate cell proliferation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of hepatic stellate cell proliferation." [GO_REF:0000058, GOC:TermGenie, PMID:15358192] synonym: "down regulation of hepatic perisinusoidal cell proliferation" EXACT [GOC:TermGenie] synonym: "down regulation of hepatic stellate cell proliferation" EXACT [GOC:TermGenie] synonym: "down regulation of Ito cell proliferation" EXACT [GOC:TermGenie] synonym: "down regulation of perisinusoidal cell proliferation" EXACT [GOC:TermGenie] synonym: "down-regulation of hepatic perisinusoidal cell proliferation" EXACT [GOC:TermGenie] synonym: "down-regulation of hepatic stellate cell proliferation" EXACT [GOC:TermGenie] synonym: "down-regulation of Ito cell proliferation" EXACT [GOC:TermGenie] synonym: "down-regulation of perisinusoidal cell proliferation" EXACT [GOC:TermGenie] synonym: "downregulation of hepatic perisinusoidal cell proliferation" EXACT [GOC:TermGenie] synonym: "downregulation of hepatic stellate cell proliferation" EXACT [GOC:TermGenie] synonym: "downregulation of Ito cell proliferation" EXACT [GOC:TermGenie] synonym: "downregulation of perisinusoidal cell proliferation" EXACT [GOC:TermGenie] synonym: "inhibition of hepatic perisinusoidal cell proliferation" NARROW [GOC:TermGenie] synonym: "inhibition of hepatic stellate cell proliferation" NARROW [GOC:TermGenie] synonym: "inhibition of Ito cell proliferation" NARROW [GOC:TermGenie] synonym: "inhibition of perisinusoidal cell proliferation" NARROW [GOC:TermGenie] synonym: "negative regulation of hepatic perisinusoidal cell proliferation" EXACT [GOC:TermGenie] synonym: "negative regulation of Ito cell proliferation" EXACT [GOC:TermGenie] synonym: "negative regulation of perisinusoidal cell proliferation" EXACT [GOC:TermGenie] is_a: GO:0048147 ! negative regulation of fibroblast proliferation is_a: GO:1904897 ! regulation of hepatic stellate cell proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:1990922 ! negatively regulates hepatic stellate cell proliferation relationship: RO:0002212 GO:1990922 ! negatively regulates hepatic stellate cell proliferation property_value: RO:0002161 NCBITaxon:4751 creation_date: 2016-01-14T15:57:06Z [Term] id: GO:1904899 name: positive regulation of hepatic stellate cell proliferation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of hepatic stellate cell proliferation." [GO_REF:0000058, GOC:TermGenie, PMID:15358192] synonym: "activation of hepatic perisinusoidal cell proliferation" NARROW [GOC:TermGenie] synonym: "activation of hepatic stellate cell proliferation" NARROW [GOC:TermGenie] synonym: "activation of Ito cell proliferation" NARROW [GOC:TermGenie] synonym: "activation of perisinusoidal cell proliferation" NARROW [GOC:TermGenie] synonym: "positive regulation of hepatic perisinusoidal cell proliferation" EXACT [GOC:TermGenie] synonym: "positive regulation of Ito cell proliferation" EXACT [GOC:TermGenie] synonym: "positive regulation of perisinusoidal cell proliferation" EXACT [GOC:TermGenie] synonym: "up regulation of hepatic perisinusoidal cell proliferation" EXACT [GOC:TermGenie] synonym: "up regulation of hepatic stellate cell proliferation" EXACT [GOC:TermGenie] synonym: "up regulation of Ito cell proliferation" EXACT [GOC:TermGenie] synonym: "up regulation of perisinusoidal cell proliferation" EXACT [GOC:TermGenie] synonym: "up-regulation of hepatic perisinusoidal cell proliferation" EXACT [GOC:TermGenie] synonym: "up-regulation of hepatic stellate cell proliferation" EXACT [GOC:TermGenie] synonym: "up-regulation of Ito cell proliferation" EXACT [GOC:TermGenie] synonym: "up-regulation of perisinusoidal cell proliferation" EXACT [GOC:TermGenie] synonym: "upregulation of hepatic perisinusoidal cell proliferation" EXACT [GOC:TermGenie] synonym: "upregulation of hepatic stellate cell proliferation" EXACT [GOC:TermGenie] synonym: "upregulation of Ito cell proliferation" EXACT [GOC:TermGenie] synonym: "upregulation of perisinusoidal cell proliferation" EXACT [GOC:TermGenie] is_a: GO:0048146 ! positive regulation of fibroblast proliferation is_a: GO:1904897 ! regulation of hepatic stellate cell proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:1990922 ! positively regulates hepatic stellate cell proliferation relationship: RO:0002213 GO:1990922 ! positively regulates hepatic stellate cell proliferation property_value: RO:0002161 NCBITaxon:4751 creation_date: 2016-01-14T15:57:13Z [Term] id: GO:1904933 name: regulation of cell proliferation in midbrain namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cell proliferation in midbrain." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:18953410, PMID:24431302] synonym: "regulation of cell proliferation in mesencephalon" EXACT [GOC:TermGenie] synonym: "regulation of mesencepahalic cell proliferation" RELATED [GOC:TermGenie] is_a: GO:2000177 ! regulation of neural precursor cell proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0033278 ! regulates cell proliferation in midbrain relationship: RO:0002211 GO:0033278 ! regulates cell proliferation in midbrain creation_date: 2016-02-01T13:16:11Z [Term] id: GO:1904934 name: negative regulation of cell proliferation in midbrain namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of cell proliferation in midbrain." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:18953410, PMID:24431302] synonym: "down regulation of cell proliferation in mesencephalon" EXACT [GOC:TermGenie] synonym: "down regulation of cell proliferation in midbrain" EXACT [GOC:TermGenie] synonym: "down regulation of mesencepahalic cell proliferation" RELATED [GOC:TermGenie] synonym: "down-regulation of cell proliferation in mesencephalon" EXACT [GOC:TermGenie] synonym: "down-regulation of cell proliferation in midbrain" EXACT [GOC:TermGenie] synonym: "down-regulation of mesencepahalic cell proliferation" RELATED [GOC:TermGenie] synonym: "downregulation of cell proliferation in mesencephalon" EXACT [GOC:TermGenie] synonym: "downregulation of cell proliferation in midbrain" EXACT [GOC:TermGenie] synonym: "downregulation of mesencepahalic cell proliferation" RELATED [GOC:TermGenie] synonym: "inhibition of cell proliferation in mesencephalon" NARROW [GOC:TermGenie] synonym: "inhibition of cell proliferation in midbrain" NARROW [GOC:TermGenie] synonym: "inhibition of mesencepahalic cell proliferation" RELATED [GOC:TermGenie] synonym: "negative regulation of cell proliferation in mesencephalon" EXACT [GOC:TermGenie] synonym: "negative regulation of mesencepahalic cell proliferation" RELATED [GOC:TermGenie] is_a: GO:1904933 ! regulation of cell proliferation in midbrain is_a: GO:2000178 ! negative regulation of neural precursor cell proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0033278 ! negatively regulates cell proliferation in midbrain relationship: RO:0002212 GO:0033278 ! negatively regulates cell proliferation in midbrain creation_date: 2016-02-01T13:16:19Z [Term] id: GO:1904935 name: positive regulation of cell proliferation in midbrain namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cell proliferation in midbrain." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:24431302] synonym: "activation of cell proliferation in mesencephalon" NARROW [GOC:TermGenie] synonym: "activation of cell proliferation in midbrain" NARROW [GOC:TermGenie] synonym: "activation of mesencepahalic cell proliferation" RELATED [GOC:TermGenie] synonym: "positive regulation of cell proliferation in mesencephalon" EXACT [GOC:TermGenie] synonym: "positive regulation of mesencepahalic cell proliferation" RELATED [GOC:TermGenie] synonym: "up regulation of cell proliferation in mesencephalon" EXACT [GOC:TermGenie] synonym: "up regulation of cell proliferation in midbrain" EXACT [GOC:TermGenie] synonym: "up regulation of mesencepahalic cell proliferation" RELATED [GOC:TermGenie] synonym: "up-regulation of cell proliferation in mesencephalon" EXACT [GOC:TermGenie] synonym: "up-regulation of cell proliferation in midbrain" EXACT [GOC:TermGenie] synonym: "up-regulation of mesencepahalic cell proliferation" RELATED [GOC:TermGenie] synonym: "upregulation of cell proliferation in mesencephalon" EXACT [GOC:TermGenie] synonym: "upregulation of cell proliferation in midbrain" EXACT [GOC:TermGenie] synonym: "upregulation of mesencepahalic cell proliferation" RELATED [GOC:TermGenie] is_a: GO:1904933 ! regulation of cell proliferation in midbrain is_a: GO:2000179 ! positive regulation of neural precursor cell proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0033278 ! positively regulates cell proliferation in midbrain relationship: RO:0002213 GO:0033278 ! positively regulates cell proliferation in midbrain creation_date: 2016-02-01T13:16:27Z [Term] id: GO:1904936 name: interneuron migration namespace: biological_process def: "The orderly movement of an interneuron from one site to another." [GO_REF:0000091, GOC:ah, GOC:TermGenie, PMID:18622031] synonym: "inter neuron migration" EXACT [GOC:ah] synonym: "inter-neuron migration" EXACT [GOC:ah] is_a: GO:0001764 ! neuron migration intersection_of: GO:0016477 ! cell migration intersection_of: RO:0002565 CL:0000099 ! results in movement of interneuron relationship: RO:0002565 CL:0000099 ! results in movement of interneuron creation_date: 2016-02-01T14:04:32Z [Term] id: GO:1904937 name: sensory neuron migration namespace: biological_process def: "The orderly movement of a sensory neuron from one site to another." [GO_REF:0000091, GOC:ah, GOC:TermGenie, PMID:18622031] is_a: GO:0001764 ! neuron migration intersection_of: GO:0016477 ! cell migration intersection_of: RO:0002565 CL:0000101 ! results in movement of sensory neuron relationship: RO:0002565 CL:0000101 ! results in movement of sensory neuron creation_date: 2016-02-01T14:15:50Z [Term] id: GO:1904942 name: regulation of cardiac ventricle formation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cardiac ventricle formation." [GO_REF:0000058, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:23575307] is_a: GO:1901210 ! regulation of cardiac chamber formation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0003211 ! regulates cardiac ventricle formation relationship: RO:0002211 GO:0003211 ! regulates cardiac ventricle formation creation_date: 2016-02-02T16:37:16Z [Term] id: GO:1904943 name: negative regulation of cardiac ventricle formation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of cardiac ventricle formation." [GO_REF:0000058, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:23575307] synonym: "down regulation of cardiac ventricle formation" EXACT [GOC:TermGenie] synonym: "down-regulation of cardiac ventricle formation" EXACT [GOC:TermGenie] synonym: "downregulation of cardiac ventricle formation" EXACT [GOC:TermGenie] synonym: "inhibition of cardiac ventricle formation" NARROW [GOC:TermGenie] is_a: GO:1901211 ! negative regulation of cardiac chamber formation is_a: GO:1904413 ! negative regulation of cardiac ventricle development is_a: GO:1904942 ! regulation of cardiac ventricle formation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0003211 ! negatively regulates cardiac ventricle formation relationship: RO:0002212 GO:0003211 ! negatively regulates cardiac ventricle formation creation_date: 2016-02-02T16:37:24Z [Term] id: GO:1904944 name: positive regulation of cardiac ventricle formation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cardiac ventricle formation." [GO_REF:0000058, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:23575307] synonym: "activation of cardiac ventricle formation" NARROW [GOC:TermGenie] synonym: "up regulation of cardiac ventricle formation" EXACT [GOC:TermGenie] synonym: "up-regulation of cardiac ventricle formation" EXACT [GOC:TermGenie] synonym: "upregulation of cardiac ventricle formation" EXACT [GOC:TermGenie] is_a: GO:1901212 ! positive regulation of cardiac chamber formation is_a: GO:1904942 ! regulation of cardiac ventricle formation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0003211 ! positively regulates cardiac ventricle formation relationship: RO:0002213 GO:0003211 ! positively regulates cardiac ventricle formation creation_date: 2016-02-02T16:37:31Z [Term] id: GO:1904948 name: midbrain dopaminergic neuron differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires the specialized features of a midbrain dopaminergic neuron." [GO_REF:0000086, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:17331494, PMID:19122665] synonym: "DA neurogenesis from midbrain floor plate" EXACT [PMID:19122665] synonym: "mDA neuron differentiation" EXACT [PMID:24287202] synonym: "midbrain DA neurogenesis" EXACT [PMID:19122665] synonym: "midbrain dopaminergic neuron production" EXACT [PMID:19122665] is_a: GO:0021953 ! central nervous system neuron differentiation is_a: GO:0071542 ! dopaminergic neuron differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:2000097 ! results in acquisition of features of midbrain dopaminergic neuron relationship: BFO:0000050 GO:0030901 ! part of midbrain development relationship: RO:0002315 CL:2000097 ! results in acquisition of features of midbrain dopaminergic neuron creation_date: 2016-02-04T14:38:10Z [Term] id: GO:1904949 name: ATPase complex namespace: cellular_component def: "A protein complex which is capable of ATPase activity." [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:9606181] comment: An example of this is VPS4 in Saccharomyces cerevisiae (UniProt ID P52917) in PMID:9606181 (inferred from direct assay). synonym: "VPS4 complex" NARROW [] is_a: GO:1902494 ! catalytic complex intersection_of: GO:0032991 ! protein-containing complex intersection_of: RO:0002215 GO:0016887 ! capable of ATP hydrolysis activity relationship: RO:0002215 GO:0016887 ! capable of ATP hydrolysis activity creation_date: 2016-02-04T22:13:32Z [Term] id: GO:1904950 name: negative regulation of establishment of protein localization namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of establishment of protein localization." [GO_REF:0000058, GOC:TermGenie, PMID:22761445] synonym: "down regulation of establishment of protein localisation" EXACT [GOC:TermGenie] synonym: "down regulation of establishment of protein localization" EXACT [GOC:TermGenie] synonym: "down regulation of protein positioning" EXACT [GOC:TermGenie] synonym: "down regulation of protein recruitment" EXACT [GOC:TermGenie] synonym: "down-regulation of establishment of protein localisation" EXACT [GOC:TermGenie] synonym: "down-regulation of establishment of protein localization" EXACT [GOC:TermGenie] synonym: "down-regulation of protein positioning" EXACT [GOC:TermGenie] synonym: "down-regulation of protein recruitment" EXACT [GOC:TermGenie] synonym: "downregulation of establishment of protein localisation" EXACT [GOC:TermGenie] synonym: "downregulation of establishment of protein localization" EXACT [GOC:TermGenie] synonym: "downregulation of protein positioning" EXACT [GOC:TermGenie] synonym: "downregulation of protein recruitment" EXACT [GOC:TermGenie] synonym: "inhibition of establishment of protein localisation" NARROW [GOC:TermGenie] synonym: "inhibition of establishment of protein localization" NARROW [GOC:TermGenie] synonym: "inhibition of protein positioning" NARROW [GOC:TermGenie] synonym: "inhibition of protein recruitment" NARROW [GOC:TermGenie] synonym: "negative regulation of establishment of protein localisation" EXACT [GOC:TermGenie] synonym: "negative regulation of protein positioning" EXACT [GOC:TermGenie] synonym: "negative regulation of protein recruitment" EXACT [GOC:TermGenie] is_a: GO:0048519 ! negative regulation of biological process is_a: GO:0070201 ! regulation of establishment of protein localization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0045184 ! negatively regulates establishment of protein localization relationship: RO:0002212 GO:0045184 ! negatively regulates establishment of protein localization creation_date: 2016-02-05T09:59:24Z [Term] id: GO:1904951 name: positive regulation of establishment of protein localization namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of establishment of protein localization." [GO_REF:0000058, GOC:TermGenie, PMID:22761445] synonym: "activation of establishment of protein localisation" NARROW [GOC:TermGenie] synonym: "activation of establishment of protein localization" NARROW [GOC:TermGenie] synonym: "activation of protein positioning" NARROW [GOC:TermGenie] synonym: "activation of protein recruitment" NARROW [GOC:TermGenie] synonym: "positive regulation of establishment of protein localisation" EXACT [GOC:TermGenie] synonym: "positive regulation of protein positioning" EXACT [GOC:TermGenie] synonym: "positive regulation of protein recruitment" EXACT [GOC:TermGenie] synonym: "up regulation of establishment of protein localisation" EXACT [GOC:TermGenie] synonym: "up regulation of establishment of protein localization" EXACT [GOC:TermGenie] synonym: "up regulation of protein positioning" EXACT [GOC:TermGenie] synonym: "up regulation of protein recruitment" EXACT [GOC:TermGenie] synonym: "up-regulation of establishment of protein localisation" EXACT [GOC:TermGenie] synonym: "up-regulation of establishment of protein localization" EXACT [GOC:TermGenie] synonym: "up-regulation of protein positioning" EXACT [GOC:TermGenie] synonym: "up-regulation of protein recruitment" EXACT [GOC:TermGenie] synonym: "upregulation of establishment of protein localisation" EXACT [GOC:TermGenie] synonym: "upregulation of establishment of protein localization" EXACT [GOC:TermGenie] synonym: "upregulation of protein positioning" EXACT [GOC:TermGenie] synonym: "upregulation of protein recruitment" EXACT [GOC:TermGenie] is_a: GO:0048518 ! positive regulation of biological process is_a: GO:0070201 ! regulation of establishment of protein localization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0045184 ! positively regulates establishment of protein localization relationship: RO:0002213 GO:0045184 ! positively regulates establishment of protein localization creation_date: 2016-02-05T09:59:32Z [Term] id: GO:1904956 name: regulation of midbrain dopaminergic neuron differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of midbrain dopaminergic neuron differentiation." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:21347250] synonym: "regulation of DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie] synonym: "regulation of mDA neuron differentiation" EXACT [GOC:TermGenie] synonym: "regulation of midbrain DA neurogenesis" EXACT [GOC:TermGenie] synonym: "regulation of midbrain dopaminergic neuron production" EXACT [GOC:TermGenie] is_a: GO:1904338 ! regulation of dopaminergic neuron differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:1904948 ! regulates midbrain dopaminergic neuron differentiation relationship: RO:0002211 GO:1904948 ! regulates midbrain dopaminergic neuron differentiation creation_date: 2016-02-09T12:00:21Z [Term] id: GO:1904957 name: negative regulation of midbrain dopaminergic neuron differentiation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of midbrain dopaminergic neuron differentiation." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie] synonym: "down regulation of DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie] synonym: "down regulation of mDA neuron differentiation" EXACT [GOC:TermGenie] synonym: "down regulation of midbrain DA neurogenesis" EXACT [GOC:TermGenie] synonym: "down regulation of midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie] synonym: "down regulation of midbrain dopaminergic neuron production" EXACT [GOC:TermGenie] synonym: "down-regulation of DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie] synonym: "down-regulation of mDA neuron differentiation" EXACT [GOC:TermGenie] synonym: "down-regulation of midbrain DA neurogenesis" EXACT [GOC:TermGenie] synonym: "down-regulation of midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie] synonym: "down-regulation of midbrain dopaminergic neuron production" EXACT [GOC:TermGenie] synonym: "downregulation of DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie] synonym: "downregulation of mDA neuron differentiation" EXACT [GOC:TermGenie] synonym: "downregulation of midbrain DA neurogenesis" EXACT [GOC:TermGenie] synonym: "downregulation of midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie] synonym: "downregulation of midbrain dopaminergic neuron production" EXACT [GOC:TermGenie] synonym: "inhibition of DA neurogenesis from midbrain floor plate" NARROW [GOC:TermGenie] synonym: "inhibition of mDA neuron differentiation" NARROW [GOC:TermGenie] synonym: "inhibition of midbrain DA neurogenesis" NARROW [GOC:TermGenie] synonym: "inhibition of midbrain dopaminergic neuron differentiation" NARROW [GOC:TermGenie] synonym: "inhibition of midbrain dopaminergic neuron production" NARROW [GOC:TermGenie] synonym: "negative regulation of DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie] synonym: "negative regulation of mDA neuron differentiation" EXACT [GOC:TermGenie] synonym: "negative regulation of midbrain DA neurogenesis" EXACT [GOC:TermGenie] synonym: "negative regulation of midbrain dopaminergic neuron production" EXACT [GOC:TermGenie] is_a: GO:1904339 ! negative regulation of dopaminergic neuron differentiation is_a: GO:1904956 ! regulation of midbrain dopaminergic neuron differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:1904948 ! negatively regulates midbrain dopaminergic neuron differentiation relationship: RO:0002212 GO:1904948 ! negatively regulates midbrain dopaminergic neuron differentiation creation_date: 2016-02-09T12:00:29Z [Term] id: GO:1904958 name: positive regulation of midbrain dopaminergic neuron differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of midbrain dopaminergic neuron differentiation." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:21347250] synonym: "activation of DA neurogenesis from midbrain floor plate" NARROW [GOC:TermGenie] synonym: "activation of mDA neuron differentiation" NARROW [GOC:TermGenie] synonym: "activation of midbrain DA neurogenesis" NARROW [GOC:TermGenie] synonym: "activation of midbrain dopaminergic neuron differentiation" NARROW [GOC:TermGenie] synonym: "activation of midbrain dopaminergic neuron production" NARROW [GOC:TermGenie] synonym: "positive regulation of DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie] synonym: "positive regulation of mDA neuron differentiation" EXACT [GOC:TermGenie] synonym: "positive regulation of midbrain DA neurogenesis" EXACT [GOC:TermGenie] synonym: "positive regulation of midbrain dopaminergic neuron production" EXACT [GOC:TermGenie] synonym: "up regulation of DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie] synonym: "up regulation of mDA neuron differentiation" EXACT [GOC:TermGenie] synonym: "up regulation of midbrain DA neurogenesis" EXACT [GOC:TermGenie] synonym: "up regulation of midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie] synonym: "up regulation of midbrain dopaminergic neuron production" EXACT [GOC:TermGenie] synonym: "up-regulation of DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie] synonym: "up-regulation of mDA neuron differentiation" EXACT [GOC:TermGenie] synonym: "up-regulation of midbrain DA neurogenesis" EXACT [GOC:TermGenie] synonym: "up-regulation of midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie] synonym: "up-regulation of midbrain dopaminergic neuron production" EXACT [GOC:TermGenie] synonym: "upregulation of DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie] synonym: "upregulation of mDA neuron differentiation" EXACT [GOC:TermGenie] synonym: "upregulation of midbrain DA neurogenesis" EXACT [GOC:TermGenie] synonym: "upregulation of midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie] synonym: "upregulation of midbrain dopaminergic neuron production" EXACT [GOC:TermGenie] is_a: GO:1904340 ! positive regulation of dopaminergic neuron differentiation is_a: GO:1904956 ! regulation of midbrain dopaminergic neuron differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:1904948 ! positively regulates midbrain dopaminergic neuron differentiation relationship: RO:0002213 GO:1904948 ! positively regulates midbrain dopaminergic neuron differentiation creation_date: 2016-02-09T12:00:36Z [Term] id: GO:1904962 name: plastid to vacuole vesicle-mediated transport namespace: biological_process def: "The vesicle-mediated and directed movement of substances from plastid to vacuole." [GO_REF:0000076, GOC:TermGenie, PMID:25281689] synonym: "plastid to vacuolar carboxypeptidase Y vesicle-mediated transport" RELATED [GOC:TermGenie] is_a: GO:0007034 ! vacuolar transport is_a: GO:0016192 ! vesicle-mediated transport is_a: GO:0016482 ! cytosolic transport intersection_of: GO:0016192 ! vesicle-mediated transport intersection_of: BFO:0000066 GO:0005829 ! occurs in cytosol intersection_of: RO:0002338 GO:0009536 ! has target start location plastid intersection_of: RO:0002339 GO:0005773 ! has target end location vacuole relationship: RO:0002338 GO:0009536 ! has target start location plastid relationship: RO:0002339 GO:0005773 ! has target end location vacuole creation_date: 2016-02-10T00:14:48Z [Term] id: GO:1904969 name: slow muscle cell migration namespace: biological_process def: "The orderly movement of a slow muscle cell from one site to another." [GO_REF:0000091, GOC:TermGenie, GOC:ymb, PMID:14667409, PMID:15572133, PMID:25534553] comment: The directional migration of a slow muscle cell from one site to another within the embryo. synonym: "slow-twitch muscle cell migration" EXACT [PMID:14667409] is_a: GO:0110122 ! myotube cell migration intersection_of: GO:0016477 ! cell migration intersection_of: RO:0002565 CL:0000189 ! results in movement of slow muscle cell relationship: RO:0002565 CL:0000189 ! results in movement of slow muscle cell property_value: RO:0002161 NCBITaxon:4890 creation_date: 2016-02-16T21:20:11Z [Term] id: GO:1904970 name: brush border assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of adjacent microvilli through the formation of Ca(2+)-dependent adhesion links between them, forming a brush border." [GO_REF:0000079, GOC:lb, GOC:TermGenie, PMID:24725409] synonym: "brush border formation" EXACT [GOC:TermGenie] is_a: GO:0022607 ! cellular component assembly intersection_of: GO:0022607 ! cellular component assembly intersection_of: RO:0002588 GO:0005903 ! results in assembly of brush border relationship: RO:0002588 GO:0005903 ! results in assembly of brush border creation_date: 2016-02-17T00:58:30Z [Term] id: GO:1904977 name: lymphatic endothelial cell migration namespace: biological_process def: "The orderly movement of a lymphatic endothelial cell from one site to another in the wall of a lymphatic vessel." [GO_REF:0000091, GOC:TermGenie, PMID:25745057] is_a: GO:0043542 ! endothelial cell migration intersection_of: GO:0016477 ! cell migration intersection_of: RO:0002565 CL:0002138 ! results in movement of endothelial cell of lymphatic vessel relationship: BFO:0000050 GO:0036303 ! part of lymph vessel morphogenesis relationship: RO:0002565 CL:0002138 ! results in movement of endothelial cell of lymphatic vessel creation_date: 2016-02-18T20:49:43Z [Term] id: GO:1904983 name: glycine import into mitochondrion namespace: biological_process def: "The process in which glycine is transported from the cytosol into the mitochondrial matrix." [GO_REF:0000078, GOC:TermGenie, PMID:26821380] synonym: "transmembrane glycine transport from cytosol to mitochondrion" EXACT [] is_a: GO:0003333 ! amino acid transmembrane transport is_a: GO:0015816 ! glycine transport is_a: GO:0170036 ! import into the mitochondrion is_a: GO:1905039 ! carboxylic acid transmembrane transport intersection_of: GO:0046907 ! intracellular transport intersection_of: RO:0002338 GO:0005829 ! has target start location cytosol intersection_of: RO:0002339 GO:0005759 ! has target end location mitochondrial matrix intersection_of: RO:0002342 GO:0031966 ! results in transport across mitochondrial membrane intersection_of: RO:0004009 CHEBI:57305 ! has primary input creation_date: 2016-02-28T21:53:44Z [Term] id: GO:1904987 name: regulation of endothelial cell activation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of endothelial cell activation." [GO_REF:0000058, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:24255059] is_a: GO:0050865 ! regulation of cell activation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0042118 ! regulates endothelial cell activation relationship: RO:0002211 GO:0042118 ! regulates endothelial cell activation creation_date: 2016-02-29T16:16:09Z [Term] id: GO:1904988 name: negative regulation of endothelial cell activation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of endothelial cell activation." [GO_REF:0000058, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:24255059] synonym: "down regulation of endothelial cell activation" EXACT [GOC:TermGenie] synonym: "down-regulation of endothelial cell activation" EXACT [GOC:TermGenie] synonym: "downregulation of endothelial cell activation" EXACT [GOC:TermGenie] synonym: "inhibition of endothelial cell activation" NARROW [GOC:TermGenie] is_a: GO:0050866 ! negative regulation of cell activation is_a: GO:1904987 ! regulation of endothelial cell activation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0042118 ! negatively regulates endothelial cell activation relationship: RO:0002212 GO:0042118 ! negatively regulates endothelial cell activation creation_date: 2016-02-29T16:16:18Z [Term] id: GO:1904989 name: positive regulation of endothelial cell activation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of endothelial cell activation." [GO_REF:0000058, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:24255059] synonym: "activation of endothelial cell activation" NARROW [GOC:TermGenie] synonym: "up regulation of endothelial cell activation" EXACT [GOC:TermGenie] synonym: "up-regulation of endothelial cell activation" EXACT [GOC:TermGenie] synonym: "upregulation of endothelial cell activation" EXACT [GOC:TermGenie] is_a: GO:0050867 ! positive regulation of cell activation is_a: GO:1904987 ! regulation of endothelial cell activation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0042118 ! positively regulates endothelial cell activation relationship: RO:0002213 GO:0042118 ! positively regulates endothelial cell activation creation_date: 2016-02-29T16:16:25Z [Term] id: GO:1905000 name: regulation of membrane repolarization during atrial cardiac muscle cell action potential namespace: biological_process def: "Any process that modulates the frequency, rate or extent of membrane repolarization during atrial cardiac muscle cell action potential." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:mtg_cardiac_conduct_nov11, GOC:rph, GOC:TermGenie, PMID:21098446] synonym: "regulation of atrial repolarization" RELATED [GOC:TermGenie] synonym: "regulation of electrocardiogram QRS complex" RELATED [GOC:TermGenie] is_a: GO:0060372 ! regulation of atrial cardiac muscle cell membrane repolarization is_a: GO:1905031 ! regulation of membrane repolarization during cardiac muscle cell action potential intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0098914 ! regulates membrane repolarization during atrial cardiac muscle cell action potential relationship: RO:0002211 GO:0098914 ! regulates membrane repolarization during atrial cardiac muscle cell action potential creation_date: 2016-03-01T13:28:05Z [Term] id: GO:1905001 name: negative regulation of membrane repolarization during atrial cardiac muscle cell action potential namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of membrane repolarization during atrial cardiac muscle cell action potential." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:mtg_cardiac_conduct_nov11, GOC:rph, GOC:TermGenie, PMID:21098446] synonym: "down regulation of atrial repolarization" RELATED [GOC:TermGenie] synonym: "down regulation of electrocardiogram QRS complex" RELATED [GOC:TermGenie] synonym: "down regulation of membrane repolarization during atrial cardiac muscle cell action potential" EXACT [GOC:TermGenie] synonym: "down-regulation of atrial repolarization" RELATED [GOC:TermGenie] synonym: "down-regulation of electrocardiogram QRS complex" RELATED [GOC:TermGenie] synonym: "down-regulation of membrane repolarization during atrial cardiac muscle cell action potential" EXACT [GOC:TermGenie] synonym: "downregulation of atrial repolarization" RELATED [GOC:TermGenie] synonym: "downregulation of electrocardiogram QRS complex" RELATED [GOC:TermGenie] synonym: "downregulation of membrane repolarization during atrial cardiac muscle cell action potential" EXACT [GOC:TermGenie] synonym: "inhibition of atrial repolarization" RELATED [GOC:TermGenie] synonym: "inhibition of electrocardiogram QRS complex" RELATED [GOC:TermGenie] synonym: "inhibition of membrane repolarization during atrial cardiac muscle cell action potential" NARROW [GOC:TermGenie] synonym: "negative regulation of atrial repolarization" RELATED [GOC:TermGenie] synonym: "negative regulation of electrocardiogram QRS complex" RELATED [GOC:TermGenie] is_a: GO:1905000 ! regulation of membrane repolarization during atrial cardiac muscle cell action potential is_a: GO:1905032 ! negative regulation of membrane repolarization during cardiac muscle cell action potential intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0098914 ! negatively regulates membrane repolarization during atrial cardiac muscle cell action potential relationship: RO:0002212 GO:0098914 ! negatively regulates membrane repolarization during atrial cardiac muscle cell action potential creation_date: 2016-03-01T13:28:13Z [Term] id: GO:1905002 name: positive regulation of membrane repolarization during atrial cardiac muscle cell action potential namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of membrane repolarization during atrial cardiac muscle cell action potential." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:mtg_cardiac_conduct_nov11, GOC:rph, GOC:TermGenie, PMID:21098446] synonym: "activation of atrial repolarization" RELATED [GOC:TermGenie] synonym: "activation of electrocardiogram QRS complex" RELATED [GOC:TermGenie] synonym: "activation of membrane repolarization during atrial cardiac muscle cell action potential" NARROW [GOC:TermGenie] synonym: "positive regulation of atrial repolarization" RELATED [GOC:TermGenie] synonym: "positive regulation of electrocardiogram QRS complex" RELATED [GOC:TermGenie] synonym: "up regulation of atrial repolarization" RELATED [GOC:TermGenie] synonym: "up regulation of electrocardiogram QRS complex" RELATED [GOC:TermGenie] synonym: "up regulation of membrane repolarization during atrial cardiac muscle cell action potential" EXACT [GOC:TermGenie] synonym: "up-regulation of atrial repolarization" RELATED [GOC:TermGenie] synonym: "up-regulation of electrocardiogram QRS complex" RELATED [GOC:TermGenie] synonym: "up-regulation of membrane repolarization during atrial cardiac muscle cell action potential" EXACT [GOC:TermGenie] synonym: "upregulation of atrial repolarization" RELATED [GOC:TermGenie] synonym: "upregulation of electrocardiogram QRS complex" RELATED [GOC:TermGenie] synonym: "upregulation of membrane repolarization during atrial cardiac muscle cell action potential" EXACT [GOC:TermGenie] is_a: GO:1905000 ! regulation of membrane repolarization during atrial cardiac muscle cell action potential is_a: GO:1905033 ! positive regulation of membrane repolarization during cardiac muscle cell action potential intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0098914 ! positively regulates membrane repolarization during atrial cardiac muscle cell action potential relationship: RO:0002213 GO:0098914 ! positively regulates membrane repolarization during atrial cardiac muscle cell action potential creation_date: 2016-03-01T13:28:21Z [Term] id: GO:1905011 name: transmembrane phosphate ion transport from cytosol to vacuole namespace: biological_process def: "The directed movement of phosphate ions from the cytosol across the vacuolar membrane and into the vacuolar lumen." [GO_REF:0000078, GOC:TermGenie, PMID:26554016] synonym: "vacuolar phosphate transport" BROAD [] is_a: GO:0034486 ! vacuolar transmembrane transport is_a: GO:0035435 ! phosphate ion transmembrane transport intersection_of: GO:0006810 ! transport intersection_of: RO:0002338 GO:0005829 ! has target start location cytosol intersection_of: RO:0002339 GO:0005775 ! has target end location vacuolar lumen intersection_of: RO:0002342 GO:0005774 ! results in transport across vacuolar membrane intersection_of: RO:0004009 CHEBI:43474 ! has primary input relationship: RO:0002338 GO:0005829 ! has target start location cytosol relationship: RO:0002339 GO:0005775 ! has target end location vacuolar lumen relationship: RO:0002342 GO:0005774 ! results in transport across vacuolar membrane creation_date: 2016-03-03T00:34:12Z [Term] id: GO:1905024 name: regulation of membrane repolarization during ventricular cardiac muscle cell action potential namespace: biological_process def: "Any process that modulates the frequency, rate or extent of membrane repolarization during ventricular cardiac muscle cell action potential." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:mtg_cardiac_conduct_nov11, GOC:rph, GOC:TermGenie, PMID:19893015] synonym: "regulation of electrocardiogram T wave" RELATED [GOC:TermGenie] synonym: "regulation of regulation of ventricular cardiac muscle repolarization" RELATED [GOC:TermGenie] synonym: "regulation of ventricular repolarization" RELATED [GOC:TermGenie] is_a: GO:0060307 ! regulation of ventricular cardiac muscle cell membrane repolarization is_a: GO:1905031 ! regulation of membrane repolarization during cardiac muscle cell action potential intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0098915 ! regulates membrane repolarization during ventricular cardiac muscle cell action potential relationship: RO:0002211 GO:0098915 ! regulates membrane repolarization during ventricular cardiac muscle cell action potential creation_date: 2016-03-04T11:19:02Z [Term] id: GO:1905025 name: negative regulation of membrane repolarization during ventricular cardiac muscle cell action potential namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of membrane repolarization during ventricular cardiac muscle cell action potential." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:mtg_cardiac_conduct_nov11, GOC:rph, GOC:TermGenie, PMID:19893015] synonym: "down regulation of electrocardiogram T wave" RELATED [GOC:TermGenie] synonym: "down regulation of membrane repolarization during ventricular cardiac muscle cell action potential" EXACT [GOC:TermGenie] synonym: "down regulation of regulation of ventricular cardiac muscle repolarization" RELATED [GOC:TermGenie] synonym: "down regulation of ventricular repolarization" RELATED [GOC:TermGenie] synonym: "down-regulation of electrocardiogram T wave" RELATED [GOC:TermGenie] synonym: "down-regulation of membrane repolarization during ventricular cardiac muscle cell action potential" EXACT [GOC:TermGenie] synonym: "down-regulation of regulation of ventricular cardiac muscle repolarization" RELATED [GOC:TermGenie] synonym: "down-regulation of ventricular repolarization" RELATED [GOC:TermGenie] synonym: "downregulation of electrocardiogram T wave" RELATED [GOC:TermGenie] synonym: "downregulation of membrane repolarization during ventricular cardiac muscle cell action potential" EXACT [GOC:TermGenie] synonym: "downregulation of regulation of ventricular cardiac muscle repolarization" RELATED [GOC:TermGenie] synonym: "downregulation of ventricular repolarization" RELATED [GOC:TermGenie] synonym: "inhibition of electrocardiogram T wave" RELATED [GOC:TermGenie] synonym: "inhibition of membrane repolarization during ventricular cardiac muscle cell action potential" NARROW [GOC:TermGenie] synonym: "inhibition of regulation of ventricular cardiac muscle repolarization" RELATED [GOC:TermGenie] synonym: "inhibition of ventricular repolarization" RELATED [GOC:TermGenie] synonym: "negative regulation of electrocardiogram T wave" RELATED [GOC:TermGenie] synonym: "negative regulation of regulation of ventricular cardiac muscle repolarization" RELATED [GOC:TermGenie] synonym: "negative regulation of ventricular repolarization" RELATED [GOC:TermGenie] is_a: GO:1905024 ! regulation of membrane repolarization during ventricular cardiac muscle cell action potential is_a: GO:1905032 ! negative regulation of membrane repolarization during cardiac muscle cell action potential intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0098915 ! negatively regulates membrane repolarization during ventricular cardiac muscle cell action potential relationship: RO:0002212 GO:0098915 ! negatively regulates membrane repolarization during ventricular cardiac muscle cell action potential creation_date: 2016-03-04T11:19:12Z [Term] id: GO:1905026 name: positive regulation of membrane repolarization during ventricular cardiac muscle cell action potential namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of membrane repolarization during ventricular cardiac muscle cell action potential." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:mtg_cardiac_conduct_nov11, GOC:rph, GOC:TermGenie, PMID:19893015] synonym: "activation of electrocardiogram T wave" RELATED [GOC:TermGenie] synonym: "activation of membrane repolarization during ventricular cardiac muscle cell action potential" NARROW [GOC:TermGenie] synonym: "activation of regulation of ventricular cardiac muscle repolarization" RELATED [GOC:TermGenie] synonym: "activation of ventricular repolarization" RELATED [GOC:TermGenie] synonym: "positive regulation of electrocardiogram T wave" RELATED [GOC:TermGenie] synonym: "positive regulation of regulation of ventricular cardiac muscle repolarization" RELATED [GOC:TermGenie] synonym: "positive regulation of ventricular repolarization" RELATED [GOC:TermGenie] synonym: "up regulation of electrocardiogram T wave" RELATED [GOC:TermGenie] synonym: "up regulation of membrane repolarization during ventricular cardiac muscle cell action potential" EXACT [GOC:TermGenie] synonym: "up regulation of regulation of ventricular cardiac muscle repolarization" RELATED [GOC:TermGenie] synonym: "up regulation of ventricular repolarization" RELATED [GOC:TermGenie] synonym: "up-regulation of electrocardiogram T wave" RELATED [GOC:TermGenie] synonym: "up-regulation of membrane repolarization during ventricular cardiac muscle cell action potential" EXACT [GOC:TermGenie] synonym: "up-regulation of regulation of ventricular cardiac muscle repolarization" RELATED [GOC:TermGenie] synonym: "up-regulation of ventricular repolarization" RELATED [GOC:TermGenie] synonym: "upregulation of electrocardiogram T wave" RELATED [GOC:TermGenie] synonym: "upregulation of membrane repolarization during ventricular cardiac muscle cell action potential" EXACT [GOC:TermGenie] synonym: "upregulation of regulation of ventricular cardiac muscle repolarization" RELATED [GOC:TermGenie] synonym: "upregulation of ventricular repolarization" RELATED [GOC:TermGenie] is_a: GO:1905024 ! regulation of membrane repolarization during ventricular cardiac muscle cell action potential is_a: GO:1905033 ! positive regulation of membrane repolarization during cardiac muscle cell action potential intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0098915 ! positively regulates membrane repolarization during ventricular cardiac muscle cell action potential relationship: RO:0002213 GO:0098915 ! positively regulates membrane repolarization during ventricular cardiac muscle cell action potential creation_date: 2016-03-04T11:19:21Z [Term] id: GO:1905027 name: regulation of membrane depolarization during AV node cell action potential namespace: biological_process def: "Any process that modulates the frequency, rate or extent of membrane depolarization during AV node cell action potential." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:mtg_cardiac_conduct_nov11, GOC:rph, GOC:TermGenie, PMID:19726871] synonym: "regulation of membrane depolarization during atrioventricular node cardiac muscle cell action potential" EXACT [GOC:TermGenie] synonym: "regulation of membrane depolarization during AV node cardiac muscle cell action potential" EXACT [GOC:TermGenie] is_a: GO:0098904 ! regulation of AV node cell action potential is_a: GO:1900825 ! regulation of membrane depolarization during cardiac muscle cell action potential intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0086045 ! regulates membrane depolarization during AV node cell action potential relationship: RO:0002211 GO:0086045 ! regulates membrane depolarization during AV node cell action potential property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4895 property_value: RO:0002161 NCBITaxon:4932 creation_date: 2016-03-04T13:46:06Z [Term] id: GO:1905028 name: negative regulation of membrane depolarization during AV node cell action potential namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of membrane depolarization during AV node cell action potential." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:mtg_cardiac_conduct_nov11, GOC:rph, GOC:TermGenie, PMID:19726871] synonym: "down regulation of membrane depolarization during atrioventricular node cardiac muscle cell action potential" EXACT [GOC:TermGenie] synonym: "down regulation of membrane depolarization during AV node cardiac muscle cell action potential" EXACT [GOC:TermGenie] synonym: "down regulation of membrane depolarization during AV node cell action potential" EXACT [GOC:TermGenie] synonym: "down-regulation of membrane depolarization during atrioventricular node cardiac muscle cell action potential" EXACT [GOC:TermGenie] synonym: "down-regulation of membrane depolarization during AV node cardiac muscle cell action potential" EXACT [GOC:TermGenie] synonym: "down-regulation of membrane depolarization during AV node cell action potential" EXACT [GOC:TermGenie] synonym: "downregulation of membrane depolarization during atrioventricular node cardiac muscle cell action potential" EXACT [GOC:TermGenie] synonym: "downregulation of membrane depolarization during AV node cardiac muscle cell action potential" EXACT [GOC:TermGenie] synonym: "downregulation of membrane depolarization during AV node cell action potential" EXACT [GOC:TermGenie] synonym: "inhibition of membrane depolarization during atrioventricular node cardiac muscle cell action potential" NARROW [GOC:TermGenie] synonym: "inhibition of membrane depolarization during AV node cardiac muscle cell action potential" NARROW [GOC:TermGenie] synonym: "inhibition of membrane depolarization during AV node cell action potential" NARROW [GOC:TermGenie] synonym: "negative regulation of membrane depolarization during atrioventricular node cardiac muscle cell action potential" EXACT [GOC:TermGenie] synonym: "negative regulation of membrane depolarization during AV node cardiac muscle cell action potential" EXACT [GOC:TermGenie] is_a: GO:1900826 ! negative regulation of membrane depolarization during cardiac muscle cell action potential is_a: GO:1905027 ! regulation of membrane depolarization during AV node cell action potential intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0086045 ! negatively regulates membrane depolarization during AV node cell action potential relationship: RO:0002212 GO:0086045 ! negatively regulates membrane depolarization during AV node cell action potential property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4895 property_value: RO:0002161 NCBITaxon:4932 creation_date: 2016-03-04T13:46:15Z [Term] id: GO:1905029 name: positive regulation of membrane depolarization during AV node cell action potential namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of membrane depolarization during AV node cell action potential." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:mtg_cardiac_conduct_nov11, GOC:rph, GOC:TermGenie, PMID:19726871] synonym: "activation of membrane depolarization during atrioventricular node cardiac muscle cell action potential" NARROW [GOC:TermGenie] synonym: "activation of membrane depolarization during AV node cardiac muscle cell action potential" NARROW [GOC:TermGenie] synonym: "activation of membrane depolarization during AV node cell action potential" NARROW [GOC:TermGenie] synonym: "positive regulation of membrane depolarization during atrioventricular node cardiac muscle cell action potential" EXACT [GOC:TermGenie] synonym: "positive regulation of membrane depolarization during AV node cardiac muscle cell action potential" EXACT [GOC:TermGenie] synonym: "up regulation of membrane depolarization during atrioventricular node cardiac muscle cell action potential" EXACT [GOC:TermGenie] synonym: "up regulation of membrane depolarization during AV node cardiac muscle cell action potential" EXACT [GOC:TermGenie] synonym: "up regulation of membrane depolarization during AV node cell action potential" EXACT [GOC:TermGenie] synonym: "up-regulation of membrane depolarization during atrioventricular node cardiac muscle cell action potential" EXACT [GOC:TermGenie] synonym: "up-regulation of membrane depolarization during AV node cardiac muscle cell action potential" EXACT [GOC:TermGenie] synonym: "up-regulation of membrane depolarization during AV node cell action potential" EXACT [GOC:TermGenie] synonym: "upregulation of membrane depolarization during atrioventricular node cardiac muscle cell action potential" EXACT [GOC:TermGenie] synonym: "upregulation of membrane depolarization during AV node cardiac muscle cell action potential" EXACT [GOC:TermGenie] synonym: "upregulation of membrane depolarization during AV node cell action potential" EXACT [GOC:TermGenie] is_a: GO:1900827 ! positive regulation of membrane depolarization during cardiac muscle cell action potential is_a: GO:1905027 ! regulation of membrane depolarization during AV node cell action potential intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0086045 ! positively regulates membrane depolarization during AV node cell action potential relationship: RO:0002213 GO:0086045 ! positively regulates membrane depolarization during AV node cell action potential property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4895 property_value: RO:0002161 NCBITaxon:4932 creation_date: 2016-03-04T13:46:24Z [Term] id: GO:1905030 name: voltage-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential namespace: molecular_function def: "Any voltage-gated ion channel activity that is involved in regulation of postsynaptic membrane potential." [GO_REF:0000061, GOC:TermGenie, ISBN:9780071120005] subset: goslim_synapse synonym: "voltage gated ion channel activity involved in regulation of post-synaptic membrane potential" EXACT [GOC:TermGenie] synonym: "voltage gated ion channel activity involved in regulation of postsynaptic membrane potential" EXACT [GOC:TermGenie] synonym: "voltage-dependent ion channel activity involved in regulation of post-synaptic membrane potential" EXACT [GOC:TermGenie] synonym: "voltage-dependent ion channel activity involved in regulation of postsynaptic membrane potential" EXACT [GOC:TermGenie] synonym: "voltage-gated ion channel activity involved in regulation of post-synaptic membrane potential" EXACT [GOC:TermGenie] synonym: "voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential" BROAD [] is_a: GO:0005244 ! voltage-gated monoatomic ion channel activity intersection_of: GO:0005244 ! voltage-gated monoatomic ion channel activity intersection_of: BFO:0000050 GO:0060078 ! part of regulation of postsynaptic membrane potential relationship: BFO:0000050 GO:0060078 ! part of regulation of postsynaptic membrane potential property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/24479" xsd:anyURI creation_date: 2016-03-04T15:51:54Z [Term] id: GO:1905031 name: regulation of membrane repolarization during cardiac muscle cell action potential namespace: biological_process def: "Any process that modulates the frequency, rate or extent of membrane repolarization during cardiac muscle cell action potential." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:mtg_cardiac_conduct_nov11, GOC:rph, GOC:TermGenie, PMID:23157812] is_a: GO:0098903 ! regulation of membrane repolarization during action potential is_a: GO:0099623 ! regulation of cardiac muscle cell membrane repolarization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0086013 ! regulates membrane repolarization during cardiac muscle cell action potential relationship: RO:0002211 GO:0086013 ! regulates membrane repolarization during cardiac muscle cell action potential creation_date: 2016-03-07T10:24:34Z [Term] id: GO:1905032 name: negative regulation of membrane repolarization during cardiac muscle cell action potential namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of membrane repolarization during cardiac muscle cell action potential." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:mtg_cardiac_conduct_nov11, GOC:rph, GOC:TermGenie, PMID:23157812] synonym: "down regulation of membrane repolarization during cardiac muscle cell action potential" EXACT [GOC:TermGenie] synonym: "down-regulation of membrane repolarization during cardiac muscle cell action potential" EXACT [GOC:TermGenie] synonym: "downregulation of membrane repolarization during cardiac muscle cell action potential" EXACT [GOC:TermGenie] synonym: "inhibition of membrane repolarization during cardiac muscle cell action potential" NARROW [GOC:TermGenie] is_a: GO:0048519 ! negative regulation of biological process is_a: GO:1905031 ! regulation of membrane repolarization during cardiac muscle cell action potential intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0086013 ! negatively regulates membrane repolarization during cardiac muscle cell action potential relationship: RO:0002212 GO:0086013 ! negatively regulates membrane repolarization during cardiac muscle cell action potential creation_date: 2016-03-07T10:24:44Z [Term] id: GO:1905033 name: positive regulation of membrane repolarization during cardiac muscle cell action potential namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of membrane repolarization during cardiac muscle cell action potential." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:mtg_cardiac_conduct_nov11, GOC:rph, GOC:TermGenie, PMID:23157812] synonym: "activation of membrane repolarization during cardiac muscle cell action potential" NARROW [GOC:TermGenie] synonym: "up regulation of membrane repolarization during cardiac muscle cell action potential" EXACT [GOC:TermGenie] synonym: "up-regulation of membrane repolarization during cardiac muscle cell action potential" EXACT [GOC:TermGenie] synonym: "upregulation of membrane repolarization during cardiac muscle cell action potential" EXACT [GOC:TermGenie] is_a: GO:0048518 ! positive regulation of biological process is_a: GO:1905031 ! regulation of membrane repolarization during cardiac muscle cell action potential intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0086013 ! positively regulates membrane repolarization during cardiac muscle cell action potential relationship: RO:0002213 GO:0086013 ! positively regulates membrane repolarization during cardiac muscle cell action potential creation_date: 2016-03-07T10:24:53Z [Term] id: GO:1905038 name: regulation of membrane lipid metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of membrane lipid metabolic process." [GO_REF:0000058, GOC:TermGenie, PMID:25954280] synonym: "regulation of membrane lipid metabolism" EXACT [GOC:TermGenie] is_a: GO:0019216 ! regulation of lipid metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0006643 ! regulates membrane lipid metabolic process relationship: RO:0002211 GO:0006643 ! regulates membrane lipid metabolic process creation_date: 2016-03-08T20:41:32Z [Term] id: GO:1905039 name: carboxylic acid transmembrane transport namespace: biological_process def: "The process in which carboxylic acid is transported across a membrane." [GO_REF:0000069, GOC:TermGenie, PMID:10869563] is_a: GO:0046942 ! carboxylic acid transport is_a: GO:0055085 ! transmembrane transport intersection_of: GO:0055085 ! transmembrane transport intersection_of: RO:0004009 CHEBI:29067 ! has primary input creation_date: 2016-03-09T15:33:53Z [Term] id: GO:1905040 name: otic placode development namespace: biological_process def: "The process whose specific outcome is the progression of an otic placode over time, from its formation to the mature structure." [GO_REF:0000094, GOC:bf, GOC:mat, GOC:PARL, GOC:TermGenie, PMID:18356247] synonym: "auditory placode development" RELATED [GOC:TermGenie] synonym: "ear placode development" RELATED [GOC:TermGenie] synonym: "ear/otic placode development" RELATED [GOC:TermGenie] synonym: "octaval placode development" RELATED [GOC:TermGenie] synonym: "octaval VIII placode development" RELATED [GOC:TermGenie] synonym: "placoda otica development" EXACT [GOC:TermGenie] is_a: GO:0071696 ! ectodermal placode development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0003069 ! results in development of otic placode relationship: RO:0002162 NCBITaxon:89593 ! in taxon Craniata relationship: RO:0002296 UBERON:0003069 ! results in development of otic placode creation_date: 2016-03-10T09:30:20Z [Term] id: GO:1905063 name: regulation of vascular associated smooth muscle cell differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of vascular smooth muscle cell differentiation." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:19088079] synonym: "regulation of vascular smooth muscle cell differentiation" EXACT [GOC:TermGenie] synonym: "regulation of VSMC differentiation" EXACT [GOC:TermGenie] is_a: GO:0051150 ! regulation of smooth muscle cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0035886 ! regulates vascular associated smooth muscle cell differentiation relationship: RO:0002211 GO:0035886 ! regulates vascular associated smooth muscle cell differentiation creation_date: 2016-03-21T11:14:53Z [Term] id: GO:1905064 name: negative regulation of vascular associated smooth muscle cell differentiation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of vascular smooth muscle cell differentiation." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:19088079] synonym: "down regulation of vascular associated smooth muscle cell differentiation" EXACT [GOC:TermGenie] synonym: "down regulation of vascular smooth muscle cell differentiation" EXACT [GOC:TermGenie] synonym: "down regulation of VSMC differentiation" EXACT [GOC:TermGenie] synonym: "down-regulation of vascular associated smooth muscle cell differentiation" EXACT [GOC:TermGenie] synonym: "down-regulation of vascular smooth muscle cell differentiation" EXACT [GOC:TermGenie] synonym: "down-regulation of VSMC differentiation" EXACT [GOC:TermGenie] synonym: "downregulation of vascular associated smooth muscle cell differentiation" EXACT [GOC:TermGenie] synonym: "downregulation of vascular smooth muscle cell differentiation" EXACT [GOC:TermGenie] synonym: "downregulation of VSMC differentiation" EXACT [GOC:TermGenie] synonym: "inhibition of vascular associated smooth muscle cell differentiation" NARROW [GOC:TermGenie] synonym: "inhibition of vascular smooth muscle cell differentiation" NARROW [GOC:TermGenie] synonym: "inhibition of VSMC differentiation" NARROW [GOC:TermGenie] synonym: "negative regulation of vascular smooth muscle cell differentiation" EXACT [GOC:TermGenie] synonym: "negative regulation of VSMC differentiation" EXACT [GOC:TermGenie] is_a: GO:0051151 ! negative regulation of smooth muscle cell differentiation is_a: GO:1905063 ! regulation of vascular associated smooth muscle cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0035886 ! negatively regulates vascular associated smooth muscle cell differentiation relationship: RO:0002212 GO:0035886 ! negatively regulates vascular associated smooth muscle cell differentiation creation_date: 2016-03-21T11:15:03Z [Term] id: GO:1905065 name: positive regulation of vascular associated smooth muscle cell differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of vascular smooth muscle cell differentiation." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:19088079] synonym: "activation of vascular associated smooth muscle cell differentiation" NARROW [GOC:TermGenie] synonym: "activation of vascular smooth muscle cell differentiation" NARROW [GOC:TermGenie] synonym: "activation of VSMC differentiation" NARROW [GOC:TermGenie] synonym: "positive regulation of vascular smooth muscle cell differentiation" EXACT [GOC:TermGenie] synonym: "positive regulation of VSMC differentiation" EXACT [GOC:TermGenie] synonym: "up regulation of vascular associated smooth muscle cell differentiation" EXACT [GOC:TermGenie] synonym: "up regulation of vascular smooth muscle cell differentiation" EXACT [GOC:TermGenie] synonym: "up regulation of VSMC differentiation" EXACT [GOC:TermGenie] synonym: "up-regulation of vascular associated smooth muscle cell differentiation" EXACT [GOC:TermGenie] synonym: "up-regulation of vascular smooth muscle cell differentiation" EXACT [GOC:TermGenie] synonym: "up-regulation of VSMC differentiation" EXACT [GOC:TermGenie] synonym: "upregulation of vascular associated smooth muscle cell differentiation" EXACT [GOC:TermGenie] synonym: "upregulation of vascular smooth muscle cell differentiation" EXACT [GOC:TermGenie] synonym: "upregulation of VSMC differentiation" EXACT [GOC:TermGenie] is_a: GO:0051152 ! positive regulation of smooth muscle cell differentiation is_a: GO:1905063 ! regulation of vascular associated smooth muscle cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0035886 ! positively regulates vascular associated smooth muscle cell differentiation relationship: RO:0002213 GO:0035886 ! positively regulates vascular associated smooth muscle cell differentiation creation_date: 2016-03-21T11:15:13Z [Term] id: GO:1905069 name: allantois development namespace: biological_process def: "The process whose specific outcome is the progression of an allantois over time, from its formation to the mature structure." [GO_REF:0000094, GOC:TermGenie, PMID:17440924, PMID:21470579] synonym: "allantoic bud development" RELATED [GOC:TermGenie] is_a: GO:1903867 ! extraembryonic membrane development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0004340 ! results in development of allantois relationship: RO:0002296 UBERON:0004340 ! results in development of allantois creation_date: 2016-03-21T15:18:21Z [Term] id: GO:1905070 name: anterior visceral endoderm cell migration namespace: biological_process def: "The orderly movement of an anterior visceral endoderm cell from one site to another." [GO_REF:0000091, GOC:TermGenie, PMID:17078044] is_a: BFO:0000003 is_a: GO:0016477 ! cell migration intersection_of: GO:0016477 ! cell migration intersection_of: RO:0002565 CL:2000075 ! results in movement of anterior visceral endoderm cell relationship: RO:0002565 CL:2000075 ! results in movement of anterior visceral endoderm cell property_value: RO:0002161 NCBITaxon:4890 creation_date: 2016-03-21T15:18:32Z [Term] id: GO:1905071 name: tight junction disassembly namespace: biological_process def: "The disaggregation of an tight junction into its constituent components." [GO_REF:0000079, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:18718461] synonym: "occluding cell junction disassembly" EXACT [GOC:TermGenie] synonym: "occluding junction disassembly" EXACT [] is_a: GO:0120193 ! tight junction organization is_a: GO:0150147 ! cell-cell junction disassembly intersection_of: GO:0022411 ! cellular component disassembly intersection_of: RO:0002590 GO:0070160 ! results in disassembly of tight junction relationship: RO:0002590 GO:0070160 ! results in disassembly of tight junction creation_date: 2016-03-23T12:35:08Z [Term] id: GO:1905073 name: regulation of tight junction disassembly namespace: biological_process def: "Any process that modulates the frequency, rate or extent of tight junction disassembly." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:18718461] synonym: "regulation of occluding cell junction disassembly" EXACT [GOC:TermGenie] synonym: "regulation of occluding junction disassembly" EXACT [GOC:TermGenie] is_a: GO:0051128 ! regulation of cellular component organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:1905071 ! regulates tight junction disassembly relationship: RO:0002211 GO:1905071 ! regulates tight junction disassembly creation_date: 2016-03-23T19:32:51Z [Term] id: GO:1905074 name: negative regulation of tight junction disassembly namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of tight junction disassembly." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:18718461] synonym: "down regulation of occluding cell junction disassembly" EXACT [GOC:TermGenie] synonym: "down regulation of tight junction disassembly" EXACT [GOC:TermGenie] synonym: "down-regulation of occluding cell junction disassembly" EXACT [GOC:TermGenie] synonym: "down-regulation of tight junction disassembly" EXACT [GOC:TermGenie] synonym: "downregulation of occluding cell junction disassembly" EXACT [GOC:TermGenie] synonym: "downregulation of occluding junction disassembly" EXACT [GOC:TermGenie] synonym: "downregulation of tight junction disassembly" EXACT [GOC:TermGenie] synonym: "inhibition of occluding cell junction disassembly" NARROW [GOC:TermGenie] synonym: "inhibition of occluding junction disassembly" NARROW [GOC:TermGenie] synonym: "inhibition of tight junction disassembly" NARROW [GOC:TermGenie] synonym: "negative regulation of occluding cell junction disassembly" EXACT [GOC:TermGenie] is_a: GO:0051129 ! negative regulation of cellular component organization is_a: GO:1905073 ! regulation of tight junction disassembly intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:1905071 ! negatively regulates tight junction disassembly relationship: RO:0002212 GO:1905071 ! negatively regulates tight junction disassembly creation_date: 2016-03-23T19:33:01Z [Term] id: GO:1905075 name: positive regulation of tight junction disassembly namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of tight junction disassembly." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:18718461] synonym: "activation of occluding cell junction disassembly" NARROW [GOC:TermGenie] synonym: "activation of occluding junction disassembly" NARROW [GOC:TermGenie] synonym: "activation of tight junction disassembly" NARROW [GOC:TermGenie] synonym: "positive regulation of occluding cell junction disassembly" EXACT [GOC:TermGenie] synonym: "positive regulation of occluding junction disassembly" EXACT [GOC:TermGenie] synonym: "up regulation of occluding cell junction disassembly" EXACT [GOC:TermGenie] synonym: "up regulation of tight junction disassembly" EXACT [GOC:TermGenie] synonym: "up-regulation of occluding cell junction disassembly" EXACT [GOC:TermGenie] synonym: "up-regulation of tight junction disassembly" EXACT [GOC:TermGenie] synonym: "upregulation of occluding cell junction disassembly" EXACT [GOC:TermGenie] synonym: "upregulation of tight junction disassembly" EXACT [GOC:TermGenie] is_a: GO:0051130 ! positive regulation of cellular component organization is_a: GO:1905073 ! regulation of tight junction disassembly intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:1905071 ! positively regulates tight junction disassembly relationship: RO:0002213 GO:1905071 ! positively regulates tight junction disassembly creation_date: 2016-03-23T19:33:10Z [Term] id: GO:1905079 name: regulation of cerebellar neuron development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cerebellar neuron development." [GO_REF:0000058, GOC:TermGenie, PMID:26609159] is_a: GO:0045664 ! regulation of neuron differentiation is_a: GO:0060284 ! regulation of cell development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0098749 ! regulates cerebellar neuron development relationship: RO:0002211 GO:0098749 ! regulates cerebellar neuron development creation_date: 2016-03-24T19:45:17Z [Term] id: GO:1905080 name: negative regulation of cerebellar neuron development namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of cerebellar neuron development." [GO_REF:0000058, GOC:TermGenie, PMID:26609159] synonym: "down regulation of cerebellar neuron development" EXACT [GOC:TermGenie] synonym: "down-regulation of cerebellar neuron development" EXACT [GOC:TermGenie] synonym: "downregulation of cerebellar neuron development" EXACT [GOC:TermGenie] synonym: "inhibition of cerebellar neuron development" NARROW [GOC:TermGenie] is_a: GO:0010721 ! negative regulation of cell development is_a: GO:0045665 ! negative regulation of neuron differentiation is_a: GO:1905079 ! regulation of cerebellar neuron development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0098749 ! negatively regulates cerebellar neuron development relationship: RO:0002212 GO:0098749 ! negatively regulates cerebellar neuron development creation_date: 2016-03-24T19:45:26Z [Term] id: GO:1905081 name: positive regulation of cerebellar neuron development namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cerebellar neuron development." [GO_REF:0000058, GOC:TermGenie, PMID:26609159] synonym: "activation of cerebellar neuron development" NARROW [GOC:TermGenie] synonym: "up regulation of cerebellar neuron development" EXACT [GOC:TermGenie] synonym: "up-regulation of cerebellar neuron development" EXACT [GOC:TermGenie] synonym: "upregulation of cerebellar neuron development" EXACT [GOC:TermGenie] is_a: GO:0010720 ! positive regulation of cell development is_a: GO:0045666 ! positive regulation of neuron differentiation is_a: GO:1905079 ! regulation of cerebellar neuron development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0098749 ! positively regulates cerebellar neuron development relationship: RO:0002213 GO:0098749 ! positively regulates cerebellar neuron development creation_date: 2016-03-24T19:45:35Z [Term] id: GO:1905082 name: regulation of mitochondrial translational elongation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of mitochondrial translational elongation." [GO_REF:0000058, GOC:TermGenie, PMID:25738458] synonym: "regulation of mitochondrial translation elongation" EXACT [GOC:TermGenie] is_a: GO:0006448 ! regulation of translational elongation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0070125 ! regulates mitochondrial translational elongation relationship: RO:0002211 GO:0070125 ! regulates mitochondrial translational elongation creation_date: 2016-03-25T17:37:03Z [Term] id: GO:1905083 name: negative regulation of mitochondrial translational elongation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of mitochondrial translational elongation." [GO_REF:0000058, GOC:TermGenie, PMID:25738458] synonym: "down regulation of mitochondrial translation elongation" EXACT [GOC:TermGenie] synonym: "down regulation of mitochondrial translational elongation" EXACT [GOC:TermGenie] synonym: "down-regulation of mitochondrial translation elongation" EXACT [GOC:TermGenie] synonym: "down-regulation of mitochondrial translational elongation" EXACT [GOC:TermGenie] synonym: "downregulation of mitochondrial translation elongation" EXACT [GOC:TermGenie] synonym: "downregulation of mitochondrial translational elongation" EXACT [GOC:TermGenie] synonym: "inhibition of mitochondrial translation elongation" NARROW [GOC:TermGenie] synonym: "inhibition of mitochondrial translational elongation" NARROW [GOC:TermGenie] synonym: "negative regulation of mitochondrial translation elongation" EXACT [GOC:TermGenie] is_a: GO:0045900 ! negative regulation of translational elongation is_a: GO:0070130 ! negative regulation of mitochondrial translation is_a: GO:1905082 ! regulation of mitochondrial translational elongation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0070125 ! negatively regulates mitochondrial translational elongation relationship: RO:0002212 GO:0070125 ! negatively regulates mitochondrial translational elongation creation_date: 2016-03-25T17:37:13Z [Term] id: GO:1905084 name: positive regulation of mitochondrial translational elongation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of mitochondrial translational elongation." [GO_REF:0000058, GOC:TermGenie, PMID:25738458] synonym: "activation of mitochondrial translation elongation" NARROW [GOC:TermGenie] synonym: "activation of mitochondrial translational elongation" NARROW [GOC:TermGenie] synonym: "positive regulation of mitochondrial translation elongation" EXACT [GOC:TermGenie] synonym: "up regulation of mitochondrial translation elongation" EXACT [GOC:TermGenie] synonym: "up regulation of mitochondrial translational elongation" EXACT [GOC:TermGenie] synonym: "up-regulation of mitochondrial translation elongation" EXACT [GOC:TermGenie] synonym: "up-regulation of mitochondrial translational elongation" EXACT [GOC:TermGenie] synonym: "upregulation of mitochondrial translation elongation" EXACT [GOC:TermGenie] synonym: "upregulation of mitochondrial translational elongation" EXACT [GOC:TermGenie] is_a: GO:0045901 ! positive regulation of translational elongation is_a: GO:1905082 ! regulation of mitochondrial translational elongation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0070125 ! positively regulates mitochondrial translational elongation relationship: RO:0002213 GO:0070125 ! positively regulates mitochondrial translational elongation creation_date: 2016-03-25T17:37:22Z [Term] id: GO:1905109 name: regulation of pulmonary blood vessel remodeling namespace: biological_process def: "Any process that modulates the frequency, rate or extent of pulmonary blood vessel remodeling." [GO_REF:0000058, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:22161164] synonym: "regulation of pulmonary blood vessel remodelling" EXACT [] is_a: GO:0060312 ! regulation of blood vessel remodeling intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0101010 ! regulates pulmonary blood vessel remodeling relationship: RO:0002211 GO:0101010 ! regulates pulmonary blood vessel remodeling property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 creation_date: 2016-04-06T13:07:24Z [Term] id: GO:1905110 name: negative regulation of pulmonary blood vessel remodeling namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of pulmonary blood vessel remodeling." [GO_REF:0000058, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:22161164] synonym: "down regulation of pulmonary blood vessel remodeling" EXACT [GOC:TermGenie] synonym: "down-regulation of pulmonary blood vessel remodeling" EXACT [GOC:TermGenie] synonym: "downregulation of pulmonary blood vessel remodeling" EXACT [GOC:TermGenie] synonym: "inhibition of pulmonary blood vessel remodeling" NARROW [GOC:TermGenie] synonym: "negative regulation of pulmonary blood vessel remodelling" EXACT [] is_a: GO:0060313 ! negative regulation of blood vessel remodeling is_a: GO:1905109 ! regulation of pulmonary blood vessel remodeling intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0101010 ! negatively regulates pulmonary blood vessel remodeling relationship: RO:0002212 GO:0101010 ! negatively regulates pulmonary blood vessel remodeling property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 creation_date: 2016-04-06T13:07:33Z [Term] id: GO:1905111 name: positive regulation of pulmonary blood vessel remodeling namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of pulmonary blood vessel remodeling." [GO_REF:0000058, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:22161164] synonym: "activation of pulmonary blood vessel remodeling" NARROW [GOC:TermGenie] synonym: "positive regulation of pulmonary blood vessel remodelling" EXACT [] synonym: "up regulation of pulmonary blood vessel remodeling" EXACT [GOC:TermGenie] synonym: "up-regulation of pulmonary blood vessel remodeling" EXACT [GOC:TermGenie] synonym: "upregulation of pulmonary blood vessel remodeling" EXACT [GOC:TermGenie] is_a: GO:1905109 ! regulation of pulmonary blood vessel remodeling is_a: GO:2000504 ! positive regulation of blood vessel remodeling intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0101010 ! positively regulates pulmonary blood vessel remodeling relationship: RO:0002213 GO:0101010 ! positively regulates pulmonary blood vessel remodeling property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 creation_date: 2016-04-06T13:07:42Z [Term] id: GO:1905126 name: regulation of axo-dendritic protein transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of axo-dendritic protein transport." [GO_REF:0000058, GOC:TermGenie, PMID:20694152] synonym: "regulation of axonal protein transport" NARROW [GOC:TermGenie] is_a: GO:0033157 ! regulation of intracellular protein transport is_a: GO:0060632 ! regulation of microtubule-based movement intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0099640 ! regulates axo-dendritic protein transport relationship: RO:0002211 GO:0099640 ! regulates axo-dendritic protein transport creation_date: 2016-04-11T20:38:31Z [Term] id: GO:1905127 name: negative regulation of axo-dendritic protein transport namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of axo-dendritic protein transport." [GO_REF:0000058, GOC:TermGenie, PMID:20694152] synonym: "down regulation of axo-dendritic protein transport" EXACT [GOC:TermGenie] synonym: "down regulation of axonal protein transport" NARROW [GOC:TermGenie] synonym: "down-regulation of axo-dendritic protein transport" EXACT [GOC:TermGenie] synonym: "down-regulation of axonal protein transport" NARROW [GOC:TermGenie] synonym: "downregulation of axo-dendritic protein transport" EXACT [GOC:TermGenie] synonym: "downregulation of axonal protein transport" NARROW [GOC:TermGenie] synonym: "inhibition of axo-dendritic protein transport" NARROW [GOC:TermGenie] synonym: "inhibition of axonal protein transport" NARROW [GOC:TermGenie] synonym: "negative regulation of axonal protein transport" NARROW [GOC:TermGenie] is_a: GO:0090317 ! negative regulation of intracellular protein transport is_a: GO:1905126 ! regulation of axo-dendritic protein transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0099640 ! negatively regulates axo-dendritic protein transport relationship: RO:0002212 GO:0099640 ! negatively regulates axo-dendritic protein transport creation_date: 2016-04-11T20:38:40Z [Term] id: GO:1905128 name: positive regulation of axo-dendritic protein transport namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of axo-dendritic protein transport." [GO_REF:0000058, GOC:TermGenie, PMID:20694152] synonym: "activation of axo-dendritic protein transport" NARROW [GOC:TermGenie] synonym: "activation of axonal protein transport" NARROW [GOC:TermGenie] synonym: "positive regulation of axonal protein transport" NARROW [GOC:TermGenie] synonym: "up regulation of axo-dendritic protein transport" EXACT [GOC:TermGenie] synonym: "up regulation of axonal protein transport" NARROW [GOC:TermGenie] synonym: "up-regulation of axo-dendritic protein transport" EXACT [GOC:TermGenie] synonym: "up-regulation of axonal protein transport" NARROW [GOC:TermGenie] synonym: "upregulation of axo-dendritic protein transport" EXACT [GOC:TermGenie] synonym: "upregulation of axonal protein transport" NARROW [GOC:TermGenie] is_a: GO:0090316 ! positive regulation of intracellular protein transport is_a: GO:1905126 ! regulation of axo-dendritic protein transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0099640 ! positively regulates axo-dendritic protein transport relationship: RO:0002213 GO:0099640 ! positively regulates axo-dendritic protein transport creation_date: 2016-04-11T20:38:48Z [Term] id: GO:1905139 name: apical ectodermal ridge formation namespace: biological_process def: "The process that gives rise to the apical ectodermal ridge. This process pertains to the initial formation of a structure from unspecified parts." [GO_REF:0000081, GOC:TermGenie, PMID:18359901, PMID:9323126, PMID:9596583] synonym: "AER formation" RELATED [GOC:TermGenie] synonym: "apical epidermal ridge formation" EXACT [GOC:TermGenie] synonym: "crista ectodermalis apicalis formation" RELATED [GOC:TermGenie] is_a: BFO:0000003 is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0004356 ! results in formation of anatomical entity apical ectodermal ridge relationship: BFO:0000050 GO:0035107 ! part of appendage morphogenesis relationship: RO:0002297 UBERON:0004356 ! results in formation of anatomical entity apical ectodermal ridge creation_date: 2016-04-13T11:46:40Z [Term] id: GO:1905140 name: regulation of apical ectodermal ridge formation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of apical ectodermal ridge formation." [GO_REF:0000058, GOC:TermGenie, PMID:18359901] synonym: "regulation of AER formation" RELATED [GOC:TermGenie] synonym: "regulation of apical epidermal ridge formation" EXACT [GOC:TermGenie] synonym: "regulation of crista ectodermalis apicalis formation" RELATED [GOC:TermGenie] is_a: GO:0022603 ! regulation of anatomical structure morphogenesis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:1905139 ! regulates apical ectodermal ridge formation relationship: RO:0002211 GO:1905139 ! regulates apical ectodermal ridge formation creation_date: 2016-04-13T12:16:40Z [Term] id: GO:1905141 name: negative regulation of apical ectodermal ridge formation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of apical ectodermal ridge formation." [GO_REF:0000058, GOC:TermGenie, PMID:18359901] synonym: "down regulation of AER formation" RELATED [GOC:TermGenie] synonym: "down regulation of apical ectodermal ridge formation" EXACT [GOC:TermGenie] synonym: "down regulation of apical epidermal ridge formation" EXACT [GOC:TermGenie] synonym: "down regulation of crista ectodermalis apicalis formation" RELATED [GOC:TermGenie] synonym: "down-regulation of AER formation" RELATED [GOC:TermGenie] synonym: "down-regulation of apical ectodermal ridge formation" EXACT [GOC:TermGenie] synonym: "down-regulation of apical epidermal ridge formation" EXACT [GOC:TermGenie] synonym: "down-regulation of crista ectodermalis apicalis formation" RELATED [GOC:TermGenie] synonym: "downregulation of AER formation" RELATED [GOC:TermGenie] synonym: "downregulation of apical ectodermal ridge formation" EXACT [GOC:TermGenie] synonym: "downregulation of apical epidermal ridge formation" EXACT [GOC:TermGenie] synonym: "downregulation of crista ectodermalis apicalis formation" RELATED [GOC:TermGenie] synonym: "inhibition of AER formation" RELATED [GOC:TermGenie] synonym: "inhibition of apical ectodermal ridge formation" NARROW [GOC:TermGenie] synonym: "inhibition of apical epidermal ridge formation" NARROW [GOC:TermGenie] synonym: "inhibition of crista ectodermalis apicalis formation" RELATED [GOC:TermGenie] synonym: "negative regulation of AER formation" RELATED [GOC:TermGenie] synonym: "negative regulation of apical epidermal ridge formation" EXACT [GOC:TermGenie] synonym: "negative regulation of crista ectodermalis apicalis formation" RELATED [GOC:TermGenie] is_a: GO:0051093 ! negative regulation of developmental process is_a: GO:0051241 ! negative regulation of multicellular organismal process is_a: GO:1905140 ! regulation of apical ectodermal ridge formation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:1905139 ! negatively regulates apical ectodermal ridge formation relationship: RO:0002212 GO:1905139 ! negatively regulates apical ectodermal ridge formation creation_date: 2016-04-13T12:16:48Z [Term] id: GO:1905142 name: positive regulation of apical ectodermal ridge formation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of apical ectodermal ridge formation." [GO_REF:0000058, GOC:TermGenie, PMID:18359901] synonym: "activation of AER formation" RELATED [GOC:TermGenie] synonym: "positive regulation of AER formation" RELATED [GOC:TermGenie] synonym: "positive regulation of apical epidermal ridge formation" EXACT [GOC:TermGenie] synonym: "positive regulation of crista ectodermalis apicalis formation" RELATED [GOC:TermGenie] synonym: "up regulation of AER formation" RELATED [GOC:TermGenie] synonym: "up regulation of apical ectodermal ridge formation" EXACT [GOC:TermGenie] synonym: "up regulation of apical epidermal ridge formation" EXACT [GOC:TermGenie] synonym: "up regulation of crista ectodermalis apicalis formation" RELATED [GOC:TermGenie] synonym: "up-regulation of AER formation" RELATED [GOC:TermGenie] synonym: "up-regulation of apical ectodermal ridge formation" EXACT [GOC:TermGenie] synonym: "up-regulation of apical epidermal ridge formation" EXACT [GOC:TermGenie] synonym: "up-regulation of crista ectodermalis apicalis formation" RELATED [GOC:TermGenie] synonym: "upregulation of AER formation" RELATED [GOC:TermGenie] synonym: "upregulation of apical ectodermal ridge formation" EXACT [GOC:TermGenie] synonym: "upregulation of apical epidermal ridge formation" EXACT [GOC:TermGenie] synonym: "upregulation of crista ectodermalis apicalis formation" RELATED [GOC:TermGenie] is_a: GO:0051094 ! positive regulation of developmental process is_a: GO:0051240 ! positive regulation of multicellular organismal process is_a: GO:1905140 ! regulation of apical ectodermal ridge formation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:1905139 ! positively regulates apical ectodermal ridge formation relationship: RO:0002213 GO:1905139 ! positively regulates apical ectodermal ridge formation creation_date: 2016-04-13T12:16:57Z [Term] id: GO:1905144 name: response to acetylcholine namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an acetylcholine stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:21238497] is_a: GO:1901698 ! response to nitrogen compound is_a: GO:1901700 ! response to oxygen-containing compound intersection_of: GO:0050896 ! response to stimulus intersection_of: RO:0004009 CHEBI:15355 ! has primary input relationship: RO:0004009 CHEBI:15355 ! has primary input creation_date: 2016-04-14T08:54:49Z [Term] id: GO:1905145 name: cellular response to acetylcholine namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an acetylcholine stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:21238497] is_a: GO:1901699 ! cellular response to nitrogen compound is_a: GO:1901701 ! cellular response to oxygen-containing compound is_a: GO:1905144 ! response to acetylcholine intersection_of: GO:0070887 ! cellular response to chemical stimulus intersection_of: RO:0004009 CHEBI:15355 ! has primary input creation_date: 2016-04-14T08:54:58Z [Term] id: GO:1905146 name: lysosomal protein catabolic process namespace: biological_process def: "Any cellular protein catabolic process that takes place in a lysosome." [GO_REF:0000062, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:24334770] comment: Also consider annotating to the term 'autophagy ; GO:0006914' or one of its descendants. synonym: "cellular protein breakdown in lysosome" EXACT [GOC:TermGenie] synonym: "cellular protein catabolic process in lysosome" EXACT [] synonym: "cellular protein catabolism in lysosome" EXACT [GOC:TermGenie] synonym: "cellular protein degradation in lysosome" EXACT [GOC:TermGenie] synonym: "lysosomal protein catabolism" EXACT [GOC:bf] synonym: "lysosomal protein degradation" EXACT [GOC:bf] synonym: "lysosomal proteolysis" RELATED [PMID:24334770] synonym: "proteolysis within lysosome" RELATED [GOC:bf] is_a: GO:0007039 ! protein catabolic process in the vacuole intersection_of: GO:0030163 ! protein catabolic process intersection_of: BFO:0000066 GO:0005764 ! occurs in lysosome relationship: BFO:0000066 GO:0005764 ! occurs in lysosome creation_date: 2016-04-14T12:50:34Z [Term] id: GO:1905147 name: regulation of smooth muscle hypertrophy namespace: biological_process def: "Any process that modulates the frequency, rate or extent of smooth muscle hypertrophy." [GO_REF:0000058, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:22161164] is_a: GO:0014743 ! regulation of muscle hypertrophy is_a: GO:0043502 ! regulation of muscle adaptation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0014895 ! regulates smooth muscle hypertrophy relationship: RO:0002211 GO:0014895 ! regulates smooth muscle hypertrophy property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 creation_date: 2016-04-15T12:47:07Z [Term] id: GO:1905148 name: negative regulation of smooth muscle hypertrophy namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of smooth muscle hypertrophy." [GO_REF:0000058, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:22161164] synonym: "down regulation of smooth muscle hypertrophy" EXACT [GOC:TermGenie] synonym: "down-regulation of smooth muscle hypertrophy" EXACT [GOC:TermGenie] synonym: "downregulation of smooth muscle hypertrophy" EXACT [GOC:TermGenie] synonym: "inhibition of smooth muscle hypertrophy" NARROW [GOC:TermGenie] is_a: GO:0014741 ! negative regulation of muscle hypertrophy is_a: GO:0014745 ! negative regulation of muscle adaptation is_a: GO:1905147 ! regulation of smooth muscle hypertrophy intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0014895 ! negatively regulates smooth muscle hypertrophy relationship: RO:0002212 GO:0014895 ! negatively regulates smooth muscle hypertrophy property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 creation_date: 2016-04-15T12:47:16Z [Term] id: GO:1905149 name: positive regulation of smooth muscle hypertrophy namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of smooth muscle hypertrophy." [GO_REF:0000058, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:22161164] synonym: "activation of smooth muscle hypertrophy" NARROW [GOC:TermGenie] synonym: "up regulation of smooth muscle hypertrophy" EXACT [GOC:TermGenie] synonym: "up-regulation of smooth muscle hypertrophy" EXACT [GOC:TermGenie] synonym: "upregulation of smooth muscle hypertrophy" EXACT [GOC:TermGenie] is_a: GO:0014742 ! positive regulation of muscle hypertrophy is_a: GO:0014744 ! positive regulation of muscle adaptation is_a: GO:1905147 ! regulation of smooth muscle hypertrophy intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0014895 ! positively regulates smooth muscle hypertrophy relationship: RO:0002213 GO:0014895 ! positively regulates smooth muscle hypertrophy property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 creation_date: 2016-04-15T12:47:24Z [Term] id: GO:1905150 name: regulation of voltage-gated sodium channel activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of voltage-gated sodium channel activity." [GO_REF:0000059, GOC:TermGenie, PMID:24198377] subset: gocheck_obsoletion_candidate synonym: "regulation of voltage gated sodium channel activity" EXACT [GOC:TermGenie] synonym: "regulation of voltage-dependent sodium channel activity" EXACT [GOC:TermGenie] synonym: "regulation of voltage-gated sodium ion channel activity" EXACT [GOC:TermGenie] synonym: "regulation of voltage-sensitive sodium channel" EXACT [GOC:TermGenie] is_a: GO:2000649 ! regulation of sodium ion transmembrane transporter activity intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0005248 ! regulates voltage-gated sodium channel activity relationship: RO:0002211 GO:0005248 ! regulates voltage-gated sodium channel activity creation_date: 2016-04-15T21:47:40Z [Term] id: GO:1905152 name: positive regulation of voltage-gated sodium channel activity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of voltage-gated sodium channel activity." [GO_REF:0000059, GOC:TermGenie, PMID:24198377] subset: gocheck_obsoletion_candidate synonym: "activation of voltage gated sodium channel activity" NARROW [GOC:TermGenie] synonym: "activation of voltage-dependent sodium channel activity" NARROW [GOC:TermGenie] synonym: "activation of voltage-gated sodium channel activity" NARROW [GOC:TermGenie] synonym: "activation of voltage-gated sodium ion channel activity" NARROW [GOC:TermGenie] synonym: "activation of voltage-sensitive sodium channel" NARROW [GOC:TermGenie] synonym: "positive regulation of voltage gated sodium channel activity" EXACT [GOC:TermGenie] synonym: "positive regulation of voltage-dependent sodium channel activity" EXACT [GOC:TermGenie] synonym: "positive regulation of voltage-gated sodium ion channel activity" EXACT [GOC:TermGenie] synonym: "positive regulation of voltage-sensitive sodium channel" EXACT [GOC:TermGenie] synonym: "up regulation of voltage gated sodium channel activity" EXACT [GOC:TermGenie] synonym: "up regulation of voltage-dependent sodium channel activity" EXACT [GOC:TermGenie] synonym: "up regulation of voltage-gated sodium channel activity" EXACT [GOC:TermGenie] synonym: "up regulation of voltage-gated sodium ion channel activity" EXACT [GOC:TermGenie] synonym: "up regulation of voltage-sensitive sodium channel" EXACT [GOC:TermGenie] synonym: "up-regulation of voltage gated sodium channel activity" EXACT [GOC:TermGenie] synonym: "up-regulation of voltage-dependent sodium channel activity" EXACT [GOC:TermGenie] synonym: "up-regulation of voltage-gated sodium channel activity" EXACT [GOC:TermGenie] synonym: "up-regulation of voltage-gated sodium ion channel activity" EXACT [GOC:TermGenie] synonym: "up-regulation of voltage-sensitive sodium channel" EXACT [GOC:TermGenie] synonym: "upregulation of voltage gated sodium channel activity" EXACT [GOC:TermGenie] synonym: "upregulation of voltage-dependent sodium channel activity" EXACT [GOC:TermGenie] synonym: "upregulation of voltage-gated sodium channel activity" EXACT [GOC:TermGenie] synonym: "upregulation of voltage-gated sodium ion channel activity" EXACT [GOC:TermGenie] synonym: "upregulation of voltage-sensitive sodium channel" EXACT [GOC:TermGenie] is_a: GO:1905150 ! regulation of voltage-gated sodium channel activity is_a: GO:2000651 ! positive regulation of sodium ion transmembrane transporter activity is_a: GO:2001259 ! positive regulation of cation channel activity intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0005248 ! positively regulates voltage-gated sodium channel activity relationship: RO:0002213 GO:0005248 ! positively regulates voltage-gated sodium channel activity creation_date: 2016-04-15T21:47:57Z [Term] id: GO:1905153 name: regulation of membrane invagination namespace: biological_process def: "Any process that modulates the frequency, rate or extent of membrane invagination." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:26589353] is_a: GO:0051128 ! regulation of cellular component organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0010324 ! regulates membrane invagination relationship: RO:0002211 GO:0010324 ! regulates membrane invagination creation_date: 2016-04-18T15:43:54Z [Term] id: GO:1905154 name: negative regulation of membrane invagination namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of membrane invagination." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:26589353] synonym: "down regulation of membrane invagination" EXACT [GOC:TermGenie] synonym: "down-regulation of membrane invagination" EXACT [GOC:TermGenie] synonym: "downregulation of membrane invagination" EXACT [GOC:TermGenie] synonym: "inhibition of membrane invagination" NARROW [GOC:TermGenie] is_a: GO:0051129 ! negative regulation of cellular component organization is_a: GO:1905153 ! regulation of membrane invagination intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0010324 ! negatively regulates membrane invagination relationship: RO:0002212 GO:0010324 ! negatively regulates membrane invagination creation_date: 2016-04-18T15:44:04Z [Term] id: GO:1905155 name: positive regulation of membrane invagination namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of membrane invagination." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie] synonym: "activation of membrane invagination" NARROW [GOC:TermGenie] synonym: "up regulation of membrane invagination" EXACT [GOC:TermGenie] synonym: "up-regulation of membrane invagination" EXACT [GOC:TermGenie] synonym: "upregulation of membrane invagination" EXACT [GOC:TermGenie] is_a: GO:0051130 ! positive regulation of cellular component organization is_a: GO:1905153 ! regulation of membrane invagination intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0010324 ! positively regulates membrane invagination relationship: RO:0002213 GO:0010324 ! positively regulates membrane invagination creation_date: 2016-04-18T15:44:12Z [Term] id: GO:1905156 name: negative regulation of photosynthesis namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of photosynthesis." [GO_REF:0000058, GOC:TermGenie, PMID:7592491] synonym: "down regulation of photosynthesis" EXACT [GOC:TermGenie] synonym: "down-regulation of photosynthesis" EXACT [GOC:TermGenie] synonym: "downregulation of photosynthesis" EXACT [GOC:TermGenie] synonym: "inhibition of photosynthesis" NARROW [GOC:TermGenie] is_a: GO:0009892 ! negative regulation of metabolic process is_a: GO:0010109 ! regulation of photosynthesis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0015979 ! negatively regulates photosynthesis relationship: RO:0002212 GO:0015979 ! negatively regulates photosynthesis property_value: RO:0002161 NCBITaxon:33208 property_value: RO:0002161 NCBITaxon:4895 creation_date: 2016-04-19T16:12:29Z [Term] id: GO:1905157 name: positive regulation of photosynthesis namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of photosynthesis." [GO_REF:0000058, GOC:TermGenie, PMID:7592491] synonym: "activation of photosynthesis" NARROW [GOC:TermGenie] synonym: "up regulation of photosynthesis" EXACT [GOC:TermGenie] synonym: "up-regulation of photosynthesis" EXACT [GOC:TermGenie] synonym: "upregulation of photosynthesis" EXACT [GOC:TermGenie] is_a: GO:0009893 ! positive regulation of metabolic process is_a: GO:0010109 ! regulation of photosynthesis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0015979 ! positively regulates photosynthesis relationship: RO:0002213 GO:0015979 ! positively regulates photosynthesis property_value: RO:0002161 NCBITaxon:33208 property_value: RO:0002161 NCBITaxon:4895 creation_date: 2016-04-19T16:12:39Z [Term] id: GO:1905165 name: regulation of lysosomal protein catabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of lysosomal protein catabolic process." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:23499937] synonym: "regulation of cellular protein breakdown in lysosome" EXACT [GOC:TermGenie] synonym: "regulation of cellular protein catabolic process in lysosome" EXACT [GOC:TermGenie] synonym: "regulation of cellular protein catabolism in lysosome" EXACT [GOC:TermGenie] synonym: "regulation of cellular protein degradation in lysosome" EXACT [GOC:TermGenie] synonym: "regulation of lysosomal protein catabolism" EXACT [GOC:TermGenie] synonym: "regulation of lysosomal protein degradation" EXACT [GOC:TermGenie] synonym: "regulation of lysosomal proteolysis" RELATED [GOC:TermGenie] synonym: "regulation of proteolysis within lysosome" RELATED [GOC:TermGenie] is_a: GO:1904350 ! regulation of protein catabolic process in the vacuole intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:1905146 ! regulates lysosomal protein catabolic process relationship: RO:0002211 GO:1905146 ! regulates lysosomal protein catabolic process creation_date: 2016-04-26T12:10:01Z [Term] id: GO:1905166 name: negative regulation of lysosomal protein catabolic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of lysosomal protein catabolic process." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie] synonym: "down regulation of cellular protein breakdown in lysosome" EXACT [GOC:TermGenie] synonym: "down regulation of cellular protein catabolic process in lysosome" EXACT [GOC:TermGenie] synonym: "down regulation of cellular protein catabolism in lysosome" EXACT [GOC:TermGenie] synonym: "down regulation of cellular protein degradation in lysosome" EXACT [GOC:TermGenie] synonym: "down regulation of lysosomal protein catabolic process" EXACT [GOC:TermGenie] synonym: "down regulation of lysosomal protein catabolism" EXACT [GOC:TermGenie] synonym: "down regulation of lysosomal protein degradation" EXACT [GOC:TermGenie] synonym: "down regulation of lysosomal proteolysis" RELATED [GOC:TermGenie] synonym: "down regulation of proteolysis within lysosome" RELATED [GOC:TermGenie] synonym: "down-regulation of cellular protein breakdown in lysosome" EXACT [GOC:TermGenie] synonym: "down-regulation of cellular protein catabolic process in lysosome" EXACT [GOC:TermGenie] synonym: "down-regulation of cellular protein catabolism in lysosome" EXACT [GOC:TermGenie] synonym: "down-regulation of cellular protein degradation in lysosome" EXACT [GOC:TermGenie] synonym: "down-regulation of lysosomal protein catabolic process" EXACT [GOC:TermGenie] synonym: "down-regulation of lysosomal protein catabolism" EXACT [GOC:TermGenie] synonym: "down-regulation of lysosomal protein degradation" EXACT [GOC:TermGenie] synonym: "down-regulation of lysosomal proteolysis" RELATED [GOC:TermGenie] synonym: "down-regulation of proteolysis within lysosome" RELATED [GOC:TermGenie] synonym: "downregulation of cellular protein breakdown in lysosome" EXACT [GOC:TermGenie] synonym: "downregulation of cellular protein catabolic process in lysosome" EXACT [GOC:TermGenie] synonym: "downregulation of cellular protein catabolism in lysosome" EXACT [GOC:TermGenie] synonym: "downregulation of cellular protein degradation in lysosome" EXACT [GOC:TermGenie] synonym: "downregulation of lysosomal protein catabolic process" EXACT [GOC:TermGenie] synonym: "downregulation of lysosomal protein catabolism" EXACT [GOC:TermGenie] synonym: "downregulation of lysosomal protein degradation" EXACT [GOC:TermGenie] synonym: "downregulation of lysosomal proteolysis" RELATED [GOC:TermGenie] synonym: "downregulation of proteolysis within lysosome" RELATED [GOC:TermGenie] synonym: "inhibition of cellular protein breakdown in lysosome" NARROW [GOC:TermGenie] synonym: "inhibition of cellular protein catabolic process in lysosome" NARROW [GOC:TermGenie] synonym: "inhibition of cellular protein catabolism in lysosome" NARROW [GOC:TermGenie] synonym: "inhibition of cellular protein degradation in lysosome" NARROW [GOC:TermGenie] synonym: "inhibition of lysosomal protein catabolic process" NARROW [GOC:TermGenie] synonym: "inhibition of lysosomal protein catabolism" NARROW [GOC:TermGenie] synonym: "inhibition of lysosomal protein degradation" NARROW [GOC:TermGenie] synonym: "inhibition of lysosomal proteolysis" RELATED [GOC:TermGenie] synonym: "inhibition of proteolysis within lysosome" RELATED [GOC:TermGenie] synonym: "negative regulation of cellular protein breakdown in lysosome" EXACT [GOC:TermGenie] synonym: "negative regulation of cellular protein catabolic process in lysosome" EXACT [GOC:TermGenie] synonym: "negative regulation of cellular protein catabolism in lysosome" EXACT [GOC:TermGenie] synonym: "negative regulation of cellular protein degradation in lysosome" EXACT [GOC:TermGenie] synonym: "negative regulation of lysosomal protein catabolism" EXACT [GOC:TermGenie] synonym: "negative regulation of lysosomal protein degradation" EXACT [GOC:TermGenie] synonym: "negative regulation of lysosomal proteolysis" RELATED [GOC:TermGenie] synonym: "negative regulation of proteolysis within lysosome" RELATED [GOC:TermGenie] is_a: GO:1904351 ! negative regulation of protein catabolic process in the vacuole is_a: GO:1905165 ! regulation of lysosomal protein catabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:1905146 ! negatively regulates lysosomal protein catabolic process relationship: RO:0002212 GO:1905146 ! negatively regulates lysosomal protein catabolic process creation_date: 2016-04-26T12:10:10Z [Term] id: GO:1905167 name: positive regulation of lysosomal protein catabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of lysosomal protein catabolic process." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie] synonym: "activation of cellular protein breakdown in lysosome" NARROW [GOC:TermGenie] synonym: "activation of cellular protein catabolic process in lysosome" NARROW [GOC:TermGenie] synonym: "activation of cellular protein catabolism in lysosome" NARROW [GOC:TermGenie] synonym: "activation of cellular protein degradation in lysosome" NARROW [GOC:TermGenie] synonym: "activation of lysosomal protein catabolic process" NARROW [GOC:TermGenie] synonym: "activation of lysosomal protein catabolism" NARROW [GOC:TermGenie] synonym: "activation of lysosomal protein degradation" NARROW [GOC:TermGenie] synonym: "activation of lysosomal proteolysis" RELATED [GOC:TermGenie] synonym: "activation of proteolysis within lysosome" RELATED [GOC:TermGenie] synonym: "positive regulation of cellular protein breakdown in lysosome" EXACT [GOC:TermGenie] synonym: "positive regulation of cellular protein catabolic process in lysosome" EXACT [GOC:TermGenie] synonym: "positive regulation of cellular protein catabolism in lysosome" EXACT [GOC:TermGenie] synonym: "positive regulation of cellular protein degradation in lysosome" EXACT [GOC:TermGenie] synonym: "positive regulation of lysosomal protein catabolism" EXACT [GOC:TermGenie] synonym: "positive regulation of lysosomal protein degradation" EXACT [GOC:TermGenie] synonym: "positive regulation of lysosomal proteolysis" RELATED [GOC:TermGenie] synonym: "positive regulation of proteolysis within lysosome" RELATED [GOC:TermGenie] synonym: "up regulation of cellular protein breakdown in lysosome" EXACT [GOC:TermGenie] synonym: "up regulation of cellular protein catabolic process in lysosome" EXACT [GOC:TermGenie] synonym: "up regulation of cellular protein catabolism in lysosome" EXACT [GOC:TermGenie] synonym: "up regulation of cellular protein degradation in lysosome" EXACT [GOC:TermGenie] synonym: "up regulation of lysosomal protein catabolic process" EXACT [GOC:TermGenie] synonym: "up regulation of lysosomal protein catabolism" EXACT [GOC:TermGenie] synonym: "up regulation of lysosomal protein degradation" EXACT [GOC:TermGenie] synonym: "up regulation of lysosomal proteolysis" RELATED [GOC:TermGenie] synonym: "up regulation of proteolysis within lysosome" RELATED [GOC:TermGenie] synonym: "up-regulation of cellular protein breakdown in lysosome" EXACT [GOC:TermGenie] synonym: "up-regulation of cellular protein catabolic process in lysosome" EXACT [GOC:TermGenie] synonym: "up-regulation of cellular protein catabolism in lysosome" EXACT [GOC:TermGenie] synonym: "up-regulation of cellular protein degradation in lysosome" EXACT [GOC:TermGenie] synonym: "up-regulation of lysosomal protein catabolic process" EXACT [GOC:TermGenie] synonym: "up-regulation of lysosomal protein catabolism" EXACT [GOC:TermGenie] synonym: "up-regulation of lysosomal protein degradation" EXACT [GOC:TermGenie] synonym: "up-regulation of lysosomal proteolysis" RELATED [GOC:TermGenie] synonym: "up-regulation of proteolysis within lysosome" RELATED [GOC:TermGenie] synonym: "upregulation of cellular protein breakdown in lysosome" EXACT [GOC:TermGenie] synonym: "upregulation of cellular protein catabolic process in lysosome" EXACT [GOC:TermGenie] synonym: "upregulation of cellular protein catabolism in lysosome" EXACT [GOC:TermGenie] synonym: "upregulation of cellular protein degradation in lysosome" EXACT [GOC:TermGenie] synonym: "upregulation of lysosomal protein catabolic process" EXACT [GOC:TermGenie] synonym: "upregulation of lysosomal protein catabolism" EXACT [GOC:TermGenie] synonym: "upregulation of lysosomal protein degradation" EXACT [GOC:TermGenie] synonym: "upregulation of lysosomal proteolysis" RELATED [GOC:TermGenie] synonym: "upregulation of proteolysis within lysosome" RELATED [GOC:TermGenie] is_a: GO:1904352 ! positive regulation of protein catabolic process in the vacuole is_a: GO:1905165 ! regulation of lysosomal protein catabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:1905146 ! positively regulates lysosomal protein catabolic process relationship: RO:0002213 GO:1905146 ! positively regulates lysosomal protein catabolic process creation_date: 2016-04-26T12:10:19Z [Term] id: GO:1905192 name: regulation of chloroplast fission namespace: biological_process def: "Any process that modulates the frequency, rate or extent of chloroplast fission." [GO_REF:0000058, GOC:TermGenie, PMID:26862170] comment: Any process that modulates the rate, frequency or extent of chloroplast fission. Chloroplast fission is the division of a chloroplast within a cell to form two or more separate chloroplast compartments. synonym: "regulation of chloroplast division" EXACT [GOC:TermGenie] is_a: GO:0033043 ! regulation of organelle organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0010020 ! regulates chloroplast fission relationship: RO:0002211 GO:0010020 ! regulates chloroplast fission property_value: RO:0002161 NCBITaxon:28009 property_value: RO:0002161 NCBITaxon:33208 property_value: RO:0002161 NCBITaxon:4751 property_value: RO:0002161 NCBITaxon:554915 creation_date: 2016-05-10T19:07:34Z [Term] id: GO:1905193 name: negative regulation of chloroplast fission namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of chloroplast fission." [GO_REF:0000058, GOC:TermGenie, PMID:26862170] comment: Any process that modulates the rate, frequency or extent of chloroplast fission. Chloroplast fission is the division of a chloroplast within a cell to form two or more separate chloroplast compartments. synonym: "down regulation of chloroplast division" EXACT [GOC:TermGenie] synonym: "down regulation of chloroplast fission" EXACT [GOC:TermGenie] synonym: "down-regulation of chloroplast division" EXACT [GOC:TermGenie] synonym: "down-regulation of chloroplast fission" EXACT [GOC:TermGenie] synonym: "downregulation of chloroplast division" EXACT [GOC:TermGenie] synonym: "downregulation of chloroplast fission" EXACT [GOC:TermGenie] synonym: "inhibition of chloroplast division" NARROW [GOC:TermGenie] synonym: "inhibition of chloroplast fission" NARROW [GOC:TermGenie] synonym: "negative regulation of chloroplast division" EXACT [GOC:TermGenie] is_a: GO:0010639 ! negative regulation of organelle organization is_a: GO:1905192 ! regulation of chloroplast fission intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0010020 ! negatively regulates chloroplast fission relationship: RO:0002212 GO:0010020 ! negatively regulates chloroplast fission property_value: RO:0002161 NCBITaxon:28009 property_value: RO:0002161 NCBITaxon:33208 property_value: RO:0002161 NCBITaxon:4751 property_value: RO:0002161 NCBITaxon:554915 creation_date: 2016-05-10T19:07:43Z [Term] id: GO:1905194 name: positive regulation of chloroplast fission namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of chloroplast fission." [GO_REF:0000058, GOC:TermGenie, PMID:26862170] comment: Any process that modulates the rate, frequency or extent of chloroplast fission. Chloroplast fission is the division of a chloroplast within a cell to form two or more separate chloroplast compartments. synonym: "activation of chloroplast division" NARROW [GOC:TermGenie] synonym: "activation of chloroplast fission" NARROW [GOC:TermGenie] synonym: "positive regulation of chloroplast division" EXACT [GOC:TermGenie] synonym: "up regulation of chloroplast division" EXACT [GOC:TermGenie] synonym: "up regulation of chloroplast fission" EXACT [GOC:TermGenie] synonym: "up-regulation of chloroplast division" EXACT [GOC:TermGenie] synonym: "up-regulation of chloroplast fission" EXACT [GOC:TermGenie] synonym: "upregulation of chloroplast division" EXACT [GOC:TermGenie] synonym: "upregulation of chloroplast fission" EXACT [GOC:TermGenie] is_a: GO:0010638 ! positive regulation of organelle organization is_a: GO:1905192 ! regulation of chloroplast fission intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0010020 ! positively regulates chloroplast fission relationship: RO:0002213 GO:0010020 ! positively regulates chloroplast fission property_value: RO:0002161 NCBITaxon:28009 property_value: RO:0002161 NCBITaxon:33208 property_value: RO:0002161 NCBITaxon:4751 property_value: RO:0002161 NCBITaxon:554915 creation_date: 2016-05-10T19:07:51Z [Term] id: GO:1905207 name: regulation of cardiocyte differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cardiocyte differentiation." [GO_REF:0000058, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:23069713] synonym: "regulation of cardiac cell differentiation" EXACT [GOC:TermGenie] synonym: "regulation of heart cell differentiation" EXACT [GOC:TermGenie] is_a: GO:0045595 ! regulation of cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0035051 ! regulates cardiocyte differentiation relationship: RO:0002211 GO:0035051 ! regulates cardiocyte differentiation creation_date: 2016-06-02T07:20:01Z [Term] id: GO:1905208 name: negative regulation of cardiocyte differentiation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of cardiocyte differentiation." [GO_REF:0000058, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:23069713] synonym: "down regulation of cardiac cell differentiation" EXACT [GOC:TermGenie] synonym: "down regulation of cardiocyte differentiation" EXACT [GOC:TermGenie] synonym: "down regulation of heart cell differentiation" EXACT [GOC:TermGenie] synonym: "down-regulation of cardiac cell differentiation" EXACT [GOC:TermGenie] synonym: "down-regulation of cardiocyte differentiation" EXACT [GOC:TermGenie] synonym: "down-regulation of heart cell differentiation" EXACT [GOC:TermGenie] synonym: "downregulation of cardiac cell differentiation" EXACT [GOC:TermGenie] synonym: "downregulation of cardiocyte differentiation" EXACT [GOC:TermGenie] synonym: "downregulation of heart cell differentiation" EXACT [GOC:TermGenie] synonym: "inhibition of cardiac cell differentiation" NARROW [GOC:TermGenie] synonym: "inhibition of cardiocyte differentiation" NARROW [GOC:TermGenie] synonym: "inhibition of heart cell differentiation" NARROW [GOC:TermGenie] synonym: "negative regulation of cardiac cell differentiation" EXACT [GOC:TermGenie] synonym: "negative regulation of heart cell differentiation" EXACT [GOC:TermGenie] is_a: GO:0045596 ! negative regulation of cell differentiation is_a: GO:0051241 ! negative regulation of multicellular organismal process is_a: GO:1905207 ! regulation of cardiocyte differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0035051 ! negatively regulates cardiocyte differentiation relationship: RO:0002212 GO:0035051 ! negatively regulates cardiocyte differentiation creation_date: 2016-06-02T07:20:09Z [Term] id: GO:1905209 name: positive regulation of cardiocyte differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cardiocyte differentiation." [GO_REF:0000058, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:23069713] synonym: "activation of cardiac cell differentiation" NARROW [GOC:TermGenie] synonym: "activation of cardiocyte differentiation" NARROW [GOC:TermGenie] synonym: "activation of heart cell differentiation" NARROW [GOC:TermGenie] synonym: "positive regulation of cardiac cell differentiation" EXACT [GOC:TermGenie] synonym: "positive regulation of heart cell differentiation" EXACT [GOC:TermGenie] synonym: "up regulation of cardiac cell differentiation" EXACT [GOC:TermGenie] synonym: "up regulation of cardiocyte differentiation" EXACT [GOC:TermGenie] synonym: "up regulation of heart cell differentiation" EXACT [GOC:TermGenie] synonym: "up-regulation of cardiac cell differentiation" EXACT [GOC:TermGenie] synonym: "up-regulation of cardiocyte differentiation" EXACT [GOC:TermGenie] synonym: "up-regulation of heart cell differentiation" EXACT [GOC:TermGenie] synonym: "upregulation of cardiac cell differentiation" EXACT [GOC:TermGenie] synonym: "upregulation of cardiocyte differentiation" EXACT [GOC:TermGenie] synonym: "upregulation of heart cell differentiation" EXACT [GOC:TermGenie] is_a: GO:0045597 ! positive regulation of cell differentiation is_a: GO:0051240 ! positive regulation of multicellular organismal process is_a: GO:1905207 ! regulation of cardiocyte differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0035051 ! positively regulates cardiocyte differentiation relationship: RO:0002213 GO:0035051 ! positively regulates cardiocyte differentiation creation_date: 2016-06-02T07:20:16Z [Term] id: GO:1905213 name: negative regulation of mitotic chromosome condensation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of mitotic chromosome condensation." [GO_REF:0000058, GOC:TermGenie, PMID:23219725] is_a: GO:0010948 ! negative regulation of cell cycle process is_a: GO:1902340 ! negative regulation of chromosome condensation is_a: GO:1903379 ! regulation of mitotic chromosome condensation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0007076 ! negatively regulates mitotic chromosome condensation relationship: RO:0002212 GO:0007076 ! negatively regulates mitotic chromosome condensation creation_date: 2016-06-03T08:41:08Z [Term] id: GO:1905216 name: positive regulation of RNA binding namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of RNA binding." [GO_REF:0000059, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:25116364] subset: gocheck_do_not_annotate synonym: "activation of RNA binding" NARROW [GOC:TermGenie] synonym: "up regulation of RNA binding" EXACT [GOC:TermGenie] synonym: "up-regulation of RNA binding" EXACT [GOC:TermGenie] synonym: "upregulation of RNA binding" EXACT [GOC:TermGenie] is_a: GO:0051099 ! positive regulation of binding intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0003723 ! positively regulates RNA binding relationship: RO:0002213 GO:0003723 ! positively regulates RNA binding creation_date: 2016-06-06T10:21:12Z [Term] id: GO:1905219 name: regulation of platelet formation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of platelet formation." [GO_REF:0000058, GOC:TermGenie, PMID:10606160] synonym: "regulation of platelet extrusion" EXACT [GOC:TermGenie] is_a: GO:0022604 ! regulation of cell morphogenesis is_a: GO:0045637 ! regulation of myeloid cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0030220 ! regulates platelet formation relationship: RO:0002211 GO:0030220 ! regulates platelet formation creation_date: 2016-06-06T22:15:46Z [Term] id: GO:1905220 name: negative regulation of platelet formation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of platelet formation." [GO_REF:0000058, GOC:TermGenie, PMID:10606160] synonym: "down regulation of platelet extrusion" EXACT [GOC:TermGenie] synonym: "down regulation of platelet formation" EXACT [GOC:TermGenie] synonym: "down-regulation of platelet extrusion" EXACT [GOC:TermGenie] synonym: "down-regulation of platelet formation" EXACT [GOC:TermGenie] synonym: "downregulation of platelet extrusion" EXACT [GOC:TermGenie] synonym: "downregulation of platelet formation" EXACT [GOC:TermGenie] synonym: "inhibition of platelet extrusion" NARROW [GOC:TermGenie] synonym: "inhibition of platelet formation" NARROW [GOC:TermGenie] synonym: "negative regulation of platelet extrusion" EXACT [GOC:TermGenie] is_a: GO:0045638 ! negative regulation of myeloid cell differentiation is_a: GO:1905219 ! regulation of platelet formation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0030220 ! negatively regulates platelet formation relationship: RO:0002212 GO:0030220 ! negatively regulates platelet formation creation_date: 2016-06-06T22:15:54Z [Term] id: GO:1905221 name: positive regulation of platelet formation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of platelet formation." [GO_REF:0000058, GOC:TermGenie, PMID:10606160] synonym: "activation of platelet extrusion" NARROW [GOC:TermGenie] synonym: "activation of platelet formation" NARROW [GOC:TermGenie] synonym: "positive regulation of platelet extrusion" EXACT [GOC:TermGenie] synonym: "up regulation of platelet extrusion" EXACT [GOC:TermGenie] synonym: "up regulation of platelet formation" EXACT [GOC:TermGenie] synonym: "up-regulation of platelet extrusion" EXACT [GOC:TermGenie] synonym: "up-regulation of platelet formation" EXACT [GOC:TermGenie] synonym: "upregulation of platelet extrusion" EXACT [GOC:TermGenie] synonym: "upregulation of platelet formation" EXACT [GOC:TermGenie] is_a: GO:0010770 ! positive regulation of cell morphogenesis is_a: GO:0045639 ! positive regulation of myeloid cell differentiation is_a: GO:1905219 ! regulation of platelet formation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0030220 ! positively regulates platelet formation relationship: RO:0002213 GO:0030220 ! positively regulates platelet formation creation_date: 2016-06-06T22:16:02Z [Term] id: GO:1905223 name: epicardium morphogenesis namespace: biological_process def: "The developmental process by which an epicardium is generated and organized." [GO_REF:0000083, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:18718461] synonym: "heart epicardium morphogenesis" EXACT [GOC:TermGenie] synonym: "pericardium visceral mesothelium morphogenesis" RELATED [GOC:TermGenie] synonym: "visceral serous pericardium of heart morphogenesis" EXACT [GOC:TermGenie] synonym: "visceral serous pericardium proper morphogenesis" EXACT [GOC:TermGenie] is_a: BFO:0000003 is_a: GO:0009653 ! anatomical structure morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0002348 ! results in morphogenesis of epicardium relationship: RO:0002298 UBERON:0002348 ! results in morphogenesis of epicardium creation_date: 2016-06-07T10:02:32Z [Term] id: GO:1905232 name: cellular response to L-glutamate namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a L-glutamate(1-) stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:25962137] synonym: "cellular response to L-glutamate(1-)" RELATED [] is_a: GO:0071230 ! cellular response to amino acid stimulus is_a: GO:1901699 ! cellular response to nitrogen compound is_a: GO:1901701 ! cellular response to oxygen-containing compound is_a: GO:1902065 ! response to L-glutamate intersection_of: GO:0070887 ! cellular response to chemical stimulus intersection_of: RO:0004009 CHEBI:29985 ! has primary input creation_date: 2016-06-07T17:30:08Z [Term] id: GO:1905268 name: negative regulation of chromatin organization namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of chromatin organization." [GO_REF:0000058, GOC:pr, GOC:TermGenie, GOC:vw, PMID:654321] synonym: "down regulation of chromatin assembly or disassembly" RELATED [] synonym: "down regulation of chromatin organisation" EXACT [GOC:TermGenie] synonym: "down regulation of chromatin organization" EXACT [GOC:TermGenie] synonym: "down regulation of establishment or maintenance of chromatin architecture" EXACT [GOC:TermGenie] synonym: "down-regulation of chromatin assembly or disassembly" RELATED [] synonym: "down-regulation of chromatin organisation" EXACT [GOC:TermGenie] synonym: "down-regulation of chromatin organization" EXACT [GOC:TermGenie] synonym: "down-regulation of establishment or maintenance of chromatin architecture" EXACT [GOC:TermGenie] synonym: "downregulation of chromatin assembly or disassembly" RELATED [] synonym: "downregulation of chromatin organisation" EXACT [GOC:TermGenie] synonym: "downregulation of chromatin organization" EXACT [GOC:TermGenie] synonym: "downregulation of establishment or maintenance of chromatin architecture" EXACT [GOC:TermGenie] synonym: "inhibition of chromatin assembly or disassembly" NARROW [] synonym: "inhibition of chromatin organisation" NARROW [GOC:TermGenie] synonym: "inhibition of chromatin organization" NARROW [GOC:TermGenie] synonym: "inhibition of establishment or maintenance of chromatin architecture" NARROW [GOC:TermGenie] synonym: "negative regulation of chromatin assembly or disassembly" RELATED [] synonym: "negative regulation of chromatin assembly/disassembly" EXACT [] synonym: "negative regulation of chromatin modification" RELATED [] synonym: "negative regulation of chromatin organisation" EXACT [GOC:TermGenie] synonym: "negative regulation of establishment or maintenance of chromatin architecture" EXACT [GOC:TermGenie] is_a: GO:0051129 ! negative regulation of cellular component organization is_a: GO:1902275 ! regulation of chromatin organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0006325 ! negatively regulates chromatin organization relationship: RO:0002212 GO:0006325 ! negatively regulates chromatin organization property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/22766" xsd:anyURI creation_date: 2016-06-15T20:14:47Z [Term] id: GO:1905269 name: positive regulation of chromatin organization namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of chromatin organization." [GO_REF:0000058, GOC:pr, GOC:TermGenie, GOC:vw, PMID:654321] synonym: "activation of chromatin assembly or disassembly" NARROW [] synonym: "activation of chromatin organisation" NARROW [GOC:TermGenie] synonym: "activation of chromatin organization" NARROW [GOC:TermGenie] synonym: "activation of establishment or maintenance of chromatin architecture" NARROW [GOC:TermGenie] synonym: "positive regulation of chromatin assembly or disassembly" RELATED [] synonym: "positive regulation of chromatin assembly/disassembly" RELATED [] synonym: "positive regulation of chromatin modification" RELATED [] synonym: "positive regulation of chromatin organisation" EXACT [GOC:TermGenie] synonym: "positive regulation of establishment or maintenance of chromatin architecture" EXACT [GOC:TermGenie] synonym: "stimulation of chromatin assembly or disassembly" NARROW [] synonym: "up regulation of chromatin assembly or disassembly" RELATED [] synonym: "up regulation of chromatin organisation" EXACT [GOC:TermGenie] synonym: "up regulation of chromatin organization" EXACT [GOC:TermGenie] synonym: "up regulation of establishment or maintenance of chromatin architecture" EXACT [GOC:TermGenie] synonym: "up-regulation of chromatin assembly or disassembly" RELATED [] synonym: "up-regulation of chromatin organisation" EXACT [GOC:TermGenie] synonym: "up-regulation of chromatin organization" EXACT [GOC:TermGenie] synonym: "up-regulation of establishment or maintenance of chromatin architecture" EXACT [GOC:TermGenie] synonym: "upregulation of chromatin assembly or disassembly" EXACT [] synonym: "upregulation of chromatin organisation" EXACT [GOC:TermGenie] synonym: "upregulation of chromatin organization" EXACT [GOC:TermGenie] synonym: "upregulation of establishment or maintenance of chromatin architecture" EXACT [GOC:TermGenie] is_a: GO:1902275 ! regulation of chromatin organization is_a: GO:2001252 ! positive regulation of chromosome organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0006325 ! positively regulates chromatin organization relationship: RO:0002213 GO:0006325 ! positively regulates chromatin organization property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/22766" xsd:anyURI creation_date: 2016-06-15T20:14:56Z [Term] id: GO:1905270 name: Meynert cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires the specialized features of a Meynert cell." [GO_REF:0000086, GOC:TermGenie, PMID:4142639] is_a: GO:0021859 ! pyramidal neuron differentiation is_a: GO:0021895 ! cerebral cortex neuron differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:2000056 ! results in acquisition of features of Meynert cell relationship: RO:0002315 CL:2000056 ! results in acquisition of features of Meynert cell creation_date: 2016-06-15T23:44:17Z [Term] id: GO:1905275 name: Rohon-Beard neuron differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires the specialized features of a Rohon-Beard neuron." [GO_REF:0000086, GOC:TermGenie, ZFIN:ZDB-PUB-120807-45] is_a: GO:0021953 ! central nervous system neuron differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000247 ! results in acquisition of features of Rohon-Beard neuron relationship: RO:0002315 CL:0000247 ! results in acquisition of features of Rohon-Beard neuron creation_date: 2016-06-16T23:17:04Z [Term] id: GO:1905276 name: regulation of epithelial tube formation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of epithelial tube formation." [GO_REF:0000058, GOC:bhm, GOC:TermGenie, PMID:25745997] comment: An example of this is MMRN2 in human (Q9H8L6) in PMID:25745997 (inferred from direct assay). is_a: GO:1905330 ! regulation of morphogenesis of an epithelium is_a: GO:2000026 ! regulation of multicellular organismal development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0072175 ! regulates epithelial tube formation relationship: RO:0002211 GO:0072175 ! regulates epithelial tube formation creation_date: 2016-06-20T09:35:41Z [Term] id: GO:1905277 name: negative regulation of epithelial tube formation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of epithelial tube formation." [GO_REF:0000058, GOC:bhm, GOC:TermGenie, PMID:25745997] comment: An example of this is MMRN2 in human (Q9H8L6) in PMID:25745997 (inferred from direct assay). synonym: "down regulation of epithelial tube formation" EXACT [GOC:TermGenie] synonym: "down-regulation of epithelial tube formation" EXACT [GOC:TermGenie] synonym: "downregulation of epithelial tube formation" EXACT [GOC:TermGenie] synonym: "inhibition of epithelial tube formation" NARROW [GOC:TermGenie] is_a: GO:0051241 ! negative regulation of multicellular organismal process is_a: GO:1905276 ! regulation of epithelial tube formation is_a: GO:1905331 ! negative regulation of morphogenesis of an epithelium intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0072175 ! negatively regulates epithelial tube formation relationship: RO:0002212 GO:0072175 ! negatively regulates epithelial tube formation creation_date: 2016-06-20T09:35:49Z [Term] id: GO:1905278 name: positive regulation of epithelial tube formation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of epithelial tube formation." [GO_REF:0000058, GOC:bhm, GOC:TermGenie, PMID:25745997] comment: An example of this is MMRN2 in human (Q9H8L6) in PMID:25745997 (inferred from direct assay). synonym: "activation of epithelial tube formation" NARROW [GOC:TermGenie] synonym: "up regulation of epithelial tube formation" EXACT [GOC:TermGenie] synonym: "up-regulation of epithelial tube formation" EXACT [GOC:TermGenie] synonym: "upregulation of epithelial tube formation" EXACT [GOC:TermGenie] is_a: GO:0051240 ! positive regulation of multicellular organismal process is_a: GO:1905276 ! regulation of epithelial tube formation is_a: GO:1905332 ! positive regulation of morphogenesis of an epithelium intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0072175 ! positively regulates epithelial tube formation relationship: RO:0002213 GO:0072175 ! positively regulates epithelial tube formation creation_date: 2016-06-20T09:35:57Z [Term] id: GO:1905285 name: fibrous ring of heart morphogenesis namespace: biological_process def: "The developmental process by which a fibrous ring of heart is generated and organized." [GO_REF:0000083, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:16037571] synonym: "annulus fibrosus cordis morphogenesis" RELATED [GOC:TermGenie] synonym: "anulus fibrosus cordis morphogenesis" RELATED [GOC:TermGenie] synonym: "anulus fibrosus of heart morphogenesis" EXACT [GOC:TermGenie] synonym: "aortic annulus morphogenesis" RELATED [GOC:TermGenie] synonym: "atrioventricular ring morphogenesis" RELATED [GOC:TermGenie] synonym: "coronary tendon morphogenesis" RELATED [GOC:TermGenie] synonym: "Lower's ring morphogenesis" RELATED [GOC:TermGenie] is_a: GO:0048729 ! tissue morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0006008 ! results in morphogenesis of fibrous ring of heart relationship: RO:0002298 UBERON:0006008 ! results in morphogenesis of fibrous ring of heart creation_date: 2016-06-21T09:46:54Z [Term] id: GO:1905288 name: vascular associated smooth muscle cell apoptotic process namespace: biological_process def: "Any apoptotic process in a vascular associated smooth muscle cell." [GO_REF:0000085, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:26493107] synonym: "vascular associated smooth muscle cell apoptosis" NARROW [GOC:TermGenie] synonym: "vascular smooth muscle cell apoptosis" NARROW [GOC:TermGenie] synonym: "vascular smooth muscle cell apoptotic process" EXACT [GOC:TermGenie] synonym: "VSMC apoptosis" NARROW [GOC:TermGenie] synonym: "VSMC apoptotic process" EXACT [GOC:TermGenie] is_a: GO:0034390 ! smooth muscle cell apoptotic process intersection_of: GO:0006915 ! apoptotic process intersection_of: BFO:0000066 CL:0000359 ! occurs in vascular associated smooth muscle cell relationship: BFO:0000066 CL:0000359 ! occurs in vascular associated smooth muscle cell creation_date: 2016-06-23T13:24:20Z [Term] id: GO:1905292 name: regulation of neural crest cell differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of neural crest cell differentiation." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:15073157] is_a: GO:2000736 ! regulation of stem cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0014033 ! regulates neural crest cell differentiation relationship: RO:0002211 GO:0014033 ! regulates neural crest cell differentiation creation_date: 2016-06-28T15:02:01Z [Term] id: GO:1905293 name: negative regulation of neural crest cell differentiation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of neural crest cell differentiation." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:15073157] synonym: "down regulation of neural crest cell differentiation" EXACT [GOC:TermGenie] synonym: "down-regulation of neural crest cell differentiation" EXACT [GOC:TermGenie] synonym: "downregulation of neural crest cell differentiation" EXACT [GOC:TermGenie] synonym: "inhibition of neural crest cell differentiation" NARROW [GOC:TermGenie] is_a: GO:0051241 ! negative regulation of multicellular organismal process is_a: GO:1905292 ! regulation of neural crest cell differentiation is_a: GO:2000737 ! negative regulation of stem cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0014033 ! negatively regulates neural crest cell differentiation relationship: RO:0002212 GO:0014033 ! negatively regulates neural crest cell differentiation creation_date: 2016-06-28T15:02:09Z [Term] id: GO:1905294 name: positive regulation of neural crest cell differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of neural crest cell differentiation." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:15073157] synonym: "activation of neural crest cell differentiation" NARROW [GOC:TermGenie] synonym: "up regulation of neural crest cell differentiation" EXACT [GOC:TermGenie] synonym: "up-regulation of neural crest cell differentiation" EXACT [GOC:TermGenie] synonym: "upregulation of neural crest cell differentiation" EXACT [GOC:TermGenie] is_a: GO:0051240 ! positive regulation of multicellular organismal process is_a: GO:1905292 ! regulation of neural crest cell differentiation is_a: GO:2000738 ! positive regulation of stem cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0014033 ! positively regulates neural crest cell differentiation relationship: RO:0002213 GO:0014033 ! positively regulates neural crest cell differentiation creation_date: 2016-06-28T15:02:16Z [Term] id: GO:1905298 name: regulation of intestinal epithelial cell development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of intestinal epithelial cell development." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:23904268] is_a: GO:0030856 ! regulation of epithelial cell differentiation is_a: GO:0060284 ! regulation of cell development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0060576 ! regulates intestinal epithelial cell development relationship: RO:0002211 GO:0060576 ! regulates intestinal epithelial cell development creation_date: 2016-06-30T11:40:47Z [Term] id: GO:1905299 name: negative regulation of intestinal epithelial cell development namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of intestinal epithelial cell development." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:23904268] synonym: "down regulation of intestinal epithelial cell development" EXACT [GOC:TermGenie] synonym: "down-regulation of intestinal epithelial cell development" EXACT [GOC:TermGenie] synonym: "downregulation of intestinal epithelial cell development" EXACT [GOC:TermGenie] synonym: "inhibition of intestinal epithelial cell development" NARROW [GOC:TermGenie] is_a: GO:0010721 ! negative regulation of cell development is_a: GO:0030857 ! negative regulation of epithelial cell differentiation is_a: GO:0051241 ! negative regulation of multicellular organismal process is_a: GO:1905298 ! regulation of intestinal epithelial cell development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0060576 ! negatively regulates intestinal epithelial cell development relationship: RO:0002212 GO:0060576 ! negatively regulates intestinal epithelial cell development creation_date: 2016-06-30T11:40:55Z [Term] id: GO:1905300 name: positive regulation of intestinal epithelial cell development namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of intestinal epithelial cell development." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:23904268] synonym: "activation of intestinal epithelial cell development" NARROW [GOC:TermGenie] synonym: "up regulation of intestinal epithelial cell development" EXACT [GOC:TermGenie] synonym: "up-regulation of intestinal epithelial cell development" EXACT [GOC:TermGenie] synonym: "upregulation of intestinal epithelial cell development" EXACT [GOC:TermGenie] is_a: GO:0010720 ! positive regulation of cell development is_a: GO:0051240 ! positive regulation of multicellular organismal process is_a: GO:1905298 ! regulation of intestinal epithelial cell development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0060576 ! positively regulates intestinal epithelial cell development relationship: RO:0002213 GO:0060576 ! positively regulates intestinal epithelial cell development creation_date: 2016-06-30T11:41:02Z [Term] id: GO:1905304 name: regulation of cardiac myofibril assembly namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cardiac myofibril assembly." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:16151019] synonym: "regulation of cardiac myofibril development" EXACT [GOC:TermGenie] synonym: "regulation of cardiac myofibril morphogenesis" EXACT [GOC:TermGenie] synonym: "regulation of heart myofibril assembly" RELATED [GOC:TermGenie] is_a: GO:0060284 ! regulation of cell development is_a: GO:0110020 ! regulation of actomyosin structure organization is_a: GO:1902115 ! regulation of organelle assembly is_a: GO:1902903 ! regulation of supramolecular fiber organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0055003 ! regulates cardiac myofibril assembly relationship: RO:0002211 GO:0055003 ! regulates cardiac myofibril assembly creation_date: 2016-07-06T10:01:49Z [Term] id: GO:1905305 name: negative regulation of cardiac myofibril assembly namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of cardiac myofibril assembly." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:16151019] synonym: "down regulation of cardiac myofibril assembly" EXACT [GOC:TermGenie] synonym: "down regulation of cardiac myofibril development" EXACT [GOC:TermGenie] synonym: "down regulation of cardiac myofibril morphogenesis" EXACT [GOC:TermGenie] synonym: "down regulation of heart myofibril assembly" RELATED [GOC:TermGenie] synonym: "down-regulation of cardiac myofibril assembly" EXACT [GOC:TermGenie] synonym: "down-regulation of cardiac myofibril development" EXACT [GOC:TermGenie] synonym: "down-regulation of cardiac myofibril morphogenesis" EXACT [GOC:TermGenie] synonym: "down-regulation of heart myofibril assembly" RELATED [GOC:TermGenie] synonym: "downregulation of cardiac myofibril assembly" EXACT [GOC:TermGenie] synonym: "downregulation of cardiac myofibril development" EXACT [GOC:TermGenie] synonym: "downregulation of cardiac myofibril morphogenesis" EXACT [GOC:TermGenie] synonym: "downregulation of heart myofibril assembly" RELATED [GOC:TermGenie] synonym: "inhibition of cardiac myofibril assembly" NARROW [GOC:TermGenie] synonym: "inhibition of cardiac myofibril development" NARROW [GOC:TermGenie] synonym: "inhibition of cardiac myofibril morphogenesis" NARROW [GOC:TermGenie] synonym: "inhibition of heart myofibril assembly" RELATED [GOC:TermGenie] synonym: "negative regulation of cardiac myofibril development" EXACT [GOC:TermGenie] synonym: "negative regulation of cardiac myofibril morphogenesis" EXACT [GOC:TermGenie] synonym: "negative regulation of heart myofibril assembly" RELATED [GOC:TermGenie] is_a: GO:0051494 ! negative regulation of cytoskeleton organization is_a: GO:1902116 ! negative regulation of organelle assembly is_a: GO:1902904 ! negative regulation of supramolecular fiber organization is_a: GO:1905304 ! regulation of cardiac myofibril assembly is_a: GO:2000726 ! negative regulation of cardiac muscle cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0055003 ! negatively regulates cardiac myofibril assembly relationship: RO:0002212 GO:0055003 ! negatively regulates cardiac myofibril assembly creation_date: 2016-07-06T10:01:58Z [Term] id: GO:1905306 name: positive regulation of cardiac myofibril assembly namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cardiac myofibril assembly." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:16151019] synonym: "activation of cardiac myofibril assembly" NARROW [GOC:TermGenie] synonym: "activation of cardiac myofibril development" NARROW [GOC:TermGenie] synonym: "activation of cardiac myofibril morphogenesis" NARROW [GOC:TermGenie] synonym: "activation of heart myofibril assembly" RELATED [GOC:TermGenie] synonym: "positive regulation of cardiac myofibril development" EXACT [GOC:TermGenie] synonym: "positive regulation of cardiac myofibril morphogenesis" EXACT [GOC:TermGenie] synonym: "positive regulation of heart myofibril assembly" RELATED [GOC:TermGenie] synonym: "up regulation of cardiac myofibril assembly" EXACT [GOC:TermGenie] synonym: "up regulation of cardiac myofibril development" EXACT [GOC:TermGenie] synonym: "up regulation of cardiac myofibril morphogenesis" EXACT [GOC:TermGenie] synonym: "up regulation of heart myofibril assembly" RELATED [GOC:TermGenie] synonym: "up-regulation of cardiac myofibril assembly" EXACT [GOC:TermGenie] synonym: "up-regulation of cardiac myofibril development" EXACT [GOC:TermGenie] synonym: "up-regulation of cardiac myofibril morphogenesis" EXACT [GOC:TermGenie] synonym: "up-regulation of heart myofibril assembly" RELATED [GOC:TermGenie] synonym: "upregulation of cardiac myofibril assembly" EXACT [GOC:TermGenie] synonym: "upregulation of cardiac myofibril development" EXACT [GOC:TermGenie] synonym: "upregulation of cardiac myofibril morphogenesis" EXACT [GOC:TermGenie] synonym: "upregulation of heart myofibril assembly" RELATED [GOC:TermGenie] is_a: GO:0051094 ! positive regulation of developmental process is_a: GO:0051495 ! positive regulation of cytoskeleton organization is_a: GO:1902117 ! positive regulation of organelle assembly is_a: GO:1902905 ! positive regulation of supramolecular fiber organization is_a: GO:1905304 ! regulation of cardiac myofibril assembly intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0055003 ! positively regulates cardiac myofibril assembly relationship: RO:0002213 GO:0055003 ! positively regulates cardiac myofibril assembly creation_date: 2016-07-06T10:02:07Z [Term] id: GO:1905310 name: regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cardiac neural crest cell migration involved in outflow tract morphogenesis." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:17628518] is_a: GO:0030334 ! regulation of cell migration intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0003253 ! regulates cardiac neural crest cell migration involved in outflow tract morphogenesis relationship: RO:0002211 GO:0003253 ! regulates cardiac neural crest cell migration involved in outflow tract morphogenesis creation_date: 2016-07-11T17:34:26Z [Term] id: GO:1905311 name: negative regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of cardiac neural crest cell migration involved in outflow tract morphogenesis." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:17628518] synonym: "down regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis" EXACT [GOC:TermGenie] synonym: "down-regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis" EXACT [GOC:TermGenie] synonym: "downregulation of cardiac neural crest cell migration involved in outflow tract morphogenesis" EXACT [GOC:TermGenie] synonym: "inhibition of cardiac neural crest cell migration involved in outflow tract morphogenesis" NARROW [GOC:TermGenie] is_a: GO:0030336 ! negative regulation of cell migration is_a: GO:1905310 ! regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0003253 ! negatively regulates cardiac neural crest cell migration involved in outflow tract morphogenesis relationship: RO:0002212 GO:0003253 ! negatively regulates cardiac neural crest cell migration involved in outflow tract morphogenesis creation_date: 2016-07-11T17:34:35Z [Term] id: GO:1905312 name: positive regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cardiac neural crest cell migration involved in outflow tract morphogenesis." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:17628518] synonym: "activation of cardiac neural crest cell migration involved in outflow tract morphogenesis" NARROW [GOC:TermGenie] synonym: "up regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis" EXACT [GOC:TermGenie] synonym: "up-regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis" EXACT [GOC:TermGenie] synonym: "upregulation of cardiac neural crest cell migration involved in outflow tract morphogenesis" EXACT [GOC:TermGenie] is_a: GO:0030335 ! positive regulation of cell migration is_a: GO:1905310 ! regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0003253 ! positively regulates cardiac neural crest cell migration involved in outflow tract morphogenesis relationship: RO:0002213 GO:0003253 ! positively regulates cardiac neural crest cell migration involved in outflow tract morphogenesis creation_date: 2016-07-11T17:34:43Z [Term] id: GO:1905315 name: cell proliferation involved in endocardial cushion morphogenesis namespace: biological_process def: "Any cell proliferation that is involved in endocardial cushion morphogenesis." [GO_REF:0000060, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:20652948] is_a: GO:0061323 ! cell proliferation involved in heart morphogenesis intersection_of: GO:0008283 ! cell population proliferation intersection_of: BFO:0000050 GO:0003203 ! part of endocardial cushion morphogenesis relationship: BFO:0000050 GO:0003203 ! part of endocardial cushion morphogenesis creation_date: 2016-07-12T13:56:36Z [Term] id: GO:1905319 name: mesenchymal stem cell migration namespace: biological_process def: "The orderly movement of a mesenchymal stem cell from one site to another." [GO_REF:0000091, GOC:TermGenie, PMID:24924806, PMID:25181476] is_a: BFO:0000003 is_a: GO:0016477 ! cell migration intersection_of: GO:0016477 ! cell migration intersection_of: RO:0002565 CL:0000134 ! results in movement of mesenchymal stem cell relationship: RO:0002565 CL:0000134 ! results in movement of mesenchymal stem cell property_value: RO:0002161 NCBITaxon:4890 creation_date: 2016-07-14T17:13:02Z [Term] id: GO:1905320 name: regulation of mesenchymal stem cell migration namespace: biological_process def: "Any process that modulates the frequency, rate or extent of mesenchymal stem cell migration." [GO_REF:0000058, GOC:TermGenie, PMID:26846297] is_a: GO:0030334 ! regulation of cell migration intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:1905319 ! regulates mesenchymal stem cell migration relationship: RO:0002211 GO:1905319 ! regulates mesenchymal stem cell migration property_value: RO:0002161 NCBITaxon:451864 creation_date: 2016-07-15T22:19:14Z [Term] id: GO:1905321 name: negative regulation of mesenchymal stem cell migration namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of mesenchymal stem cell migration." [GO_REF:0000058, GOC:TermGenie, PMID:26846297] synonym: "down regulation of mesenchymal stem cell migration" EXACT [GOC:TermGenie] synonym: "down-regulation of mesenchymal stem cell migration" EXACT [GOC:TermGenie] synonym: "downregulation of mesenchymal stem cell migration" EXACT [GOC:TermGenie] synonym: "inhibition of mesenchymal stem cell migration" NARROW [GOC:TermGenie] is_a: GO:0030336 ! negative regulation of cell migration is_a: GO:1905320 ! regulation of mesenchymal stem cell migration intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:1905319 ! negatively regulates mesenchymal stem cell migration relationship: RO:0002212 GO:1905319 ! negatively regulates mesenchymal stem cell migration property_value: RO:0002161 NCBITaxon:451864 creation_date: 2016-07-15T22:19:22Z [Term] id: GO:1905322 name: positive regulation of mesenchymal stem cell migration namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of mesenchymal stem cell migration." [GO_REF:0000058, GOC:TermGenie, PMID:26846297] synonym: "activation of mesenchymal stem cell migration" NARROW [GOC:TermGenie] synonym: "up regulation of mesenchymal stem cell migration" EXACT [GOC:TermGenie] synonym: "up-regulation of mesenchymal stem cell migration" EXACT [GOC:TermGenie] synonym: "upregulation of mesenchymal stem cell migration" EXACT [GOC:TermGenie] is_a: GO:0030335 ! positive regulation of cell migration is_a: GO:1905320 ! regulation of mesenchymal stem cell migration intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:1905319 ! positively regulates mesenchymal stem cell migration relationship: RO:0002213 GO:1905319 ! positively regulates mesenchymal stem cell migration property_value: RO:0002161 NCBITaxon:451864 creation_date: 2016-07-15T22:19:29Z [Term] id: GO:1905330 name: regulation of morphogenesis of an epithelium namespace: biological_process def: "Any process that modulates the frequency, rate or extent of morphogenesis of an epithelium." [GO_REF:0000058, GOC:bhm, GOC:TermGenie, PMID:25745997] comment: An example of this is MMRN2 in human (Q9H8L6) in PMID:25745997 (inferred from direct assay). synonym: "regulation of epithelium morphogenesis" EXACT [GOC:TermGenie] is_a: GO:0022603 ! regulation of anatomical structure morphogenesis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0002009 ! regulates morphogenesis of an epithelium relationship: RO:0002211 GO:0002009 ! regulates morphogenesis of an epithelium creation_date: 2016-07-22T07:13:49Z [Term] id: GO:1905331 name: negative regulation of morphogenesis of an epithelium namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of morphogenesis of an epithelium." [GO_REF:0000058, GOC:bhm, GOC:TermGenie, PMID:25745997] comment: An example of this is MMRN2 in human (Q9H8L6) in PMID:25745997 (inferred from direct assay). synonym: "down regulation of epithelium morphogenesis" EXACT [GOC:TermGenie] synonym: "down regulation of morphogenesis of an epithelium" EXACT [GOC:TermGenie] synonym: "down-regulation of epithelium morphogenesis" EXACT [GOC:TermGenie] synonym: "down-regulation of morphogenesis of an epithelium" EXACT [GOC:TermGenie] synonym: "downregulation of epithelium morphogenesis" EXACT [GOC:TermGenie] synonym: "downregulation of morphogenesis of an epithelium" EXACT [GOC:TermGenie] synonym: "inhibition of epithelium morphogenesis" NARROW [GOC:TermGenie] synonym: "inhibition of morphogenesis of an epithelium" NARROW [GOC:TermGenie] synonym: "negative regulation of epithelium morphogenesis" EXACT [GOC:TermGenie] is_a: GO:0051093 ! negative regulation of developmental process is_a: GO:1905330 ! regulation of morphogenesis of an epithelium intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0002009 ! negatively regulates morphogenesis of an epithelium relationship: RO:0002212 GO:0002009 ! negatively regulates morphogenesis of an epithelium creation_date: 2016-07-22T07:13:57Z [Term] id: GO:1905332 name: positive regulation of morphogenesis of an epithelium namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of morphogenesis of an epithelium." [GO_REF:0000058, GOC:bhm, GOC:TermGenie, PMID:25745997] comment: An example of this is MMRN2 in human (Q9H8L6) in PMID:25745997 (inferred from direct assay). synonym: "activation of epithelium morphogenesis" NARROW [GOC:TermGenie] synonym: "activation of morphogenesis of an epithelium" NARROW [GOC:TermGenie] synonym: "positive regulation of epithelium morphogenesis" EXACT [GOC:TermGenie] synonym: "up regulation of epithelium morphogenesis" EXACT [GOC:TermGenie] synonym: "up regulation of morphogenesis of an epithelium" EXACT [GOC:TermGenie] synonym: "up-regulation of epithelium morphogenesis" EXACT [GOC:TermGenie] synonym: "up-regulation of morphogenesis of an epithelium" EXACT [GOC:TermGenie] synonym: "upregulation of epithelium morphogenesis" EXACT [GOC:TermGenie] synonym: "upregulation of morphogenesis of an epithelium" EXACT [GOC:TermGenie] is_a: GO:0051094 ! positive regulation of developmental process is_a: GO:1905330 ! regulation of morphogenesis of an epithelium intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0002009 ! positively regulates morphogenesis of an epithelium relationship: RO:0002213 GO:0002009 ! positively regulates morphogenesis of an epithelium creation_date: 2016-07-22T07:14:05Z [Term] id: GO:1905349 name: ciliary transition zone assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form a ciliary transition zone." [GO_REF:0000079, GOC:cilia, GOC:TermGenie, PMID:21725307, PMID:23644468, PMID:24448408, PMID:26595381, PMID:26982032] synonym: "cilial transition zone assembly" EXACT [GOC:TermGenie] synonym: "cilial transition zone formation" EXACT [GOC:TermGenie] synonym: "ciliary transition zone formation" EXACT [GOC:TermGenie] synonym: "cilium transition zone assembly" EXACT [GOC:TermGenie] synonym: "cilium transition zone formation" EXACT [GOC:TermGenie] is_a: GO:0022607 ! cellular component assembly intersection_of: GO:0022607 ! cellular component assembly intersection_of: RO:0002588 GO:0035869 ! results in assembly of ciliary transition zone relationship: BFO:0000050 GO:0060271 ! part of cilium assembly relationship: RO:0002588 GO:0035869 ! results in assembly of ciliary transition zone property_value: RO:0002161 NCBITaxon:3176 property_value: RO:0002161 NCBITaxon:3378 property_value: RO:0002161 NCBITaxon:3398 property_value: RO:0002161 NCBITaxon:4890 property_value: RO:0002161 NCBITaxon:5782 creation_date: 2016-08-04T14:49:43Z [Term] id: GO:1905351 name: pericyte cell migration namespace: biological_process def: "The orderly movement of a pericyte cell from one site to another." [GO_REF:0000091, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:26268439] is_a: BFO:0000003 is_a: GO:0016477 ! cell migration intersection_of: GO:0016477 ! cell migration intersection_of: RO:0002565 CL:0000669 ! results in movement of pericyte relationship: RO:0002565 CL:0000669 ! results in movement of pericyte property_value: RO:0002161 NCBITaxon:4890 creation_date: 2016-08-05T12:01:48Z [Term] id: GO:1905383 name: protein localization to presynapse namespace: biological_process def: "A process in which a protein is transported to, or maintained in, a location within a presynapse." [GO_REF:0000087, GOC:TermGenie, PMID:24449494] synonym: "protein localisation in presynapse" EXACT [GOC:TermGenie] synonym: "protein localisation to presynapse" EXACT [GOC:TermGenie] synonym: "protein localization in presynapse" EXACT [GOC:TermGenie] synonym: "recruitment of presynaptic proteins" EXACT [PMID:24449494] is_a: GO:0035418 ! protein localization to synapse intersection_of: GO:0008104 ! intracellular protein localization intersection_of: RO:0002339 GO:0098793 ! has target end location presynapse relationship: RO:0002339 GO:0098793 ! has target end location presynapse creation_date: 2016-08-18T14:42:59Z [Term] id: GO:1905384 name: regulation of protein localization to presynapse namespace: biological_process def: "Any process that modulates the frequency, rate or extent of protein localization to presynapse." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:24449494] synonym: "regulation of protein localisation in presynapse" EXACT [GOC:TermGenie] synonym: "regulation of protein localisation to presynapse" EXACT [GOC:TermGenie] synonym: "regulation of protein localization in presynapse" EXACT [GOC:TermGenie] synonym: "regulation of recruitment of presynaptic proteins" EXACT [GOC:TermGenie] is_a: GO:1902473 ! regulation of protein localization to synapse intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:1905383 ! regulates protein localization to presynapse relationship: RO:0002211 GO:1905383 ! regulates protein localization to presynapse creation_date: 2016-08-18T14:56:00Z [Term] id: GO:1905385 name: negative regulation of protein localization to presynapse namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to presynapse." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:24449494] synonym: "down regulation of protein localisation in presynapse" EXACT [GOC:TermGenie] synonym: "down regulation of protein localisation to presynapse" EXACT [GOC:TermGenie] synonym: "down regulation of protein localization in presynapse" EXACT [GOC:TermGenie] synonym: "down regulation of protein localization to presynapse" EXACT [GOC:TermGenie] synonym: "down regulation of recruitment of presynaptic proteins" EXACT [GOC:TermGenie] synonym: "down-regulation of protein localisation in presynapse" EXACT [GOC:TermGenie] synonym: "down-regulation of protein localisation to presynapse" EXACT [GOC:TermGenie] synonym: "down-regulation of protein localization in presynapse" EXACT [GOC:TermGenie] synonym: "down-regulation of protein localization to presynapse" EXACT [GOC:TermGenie] synonym: "down-regulation of recruitment of presynaptic proteins" EXACT [GOC:TermGenie] synonym: "downregulation of protein localisation in presynapse" EXACT [GOC:TermGenie] synonym: "downregulation of protein localisation to presynapse" EXACT [GOC:TermGenie] synonym: "downregulation of protein localization in presynapse" EXACT [GOC:TermGenie] synonym: "downregulation of protein localization to presynapse" EXACT [GOC:TermGenie] synonym: "downregulation of recruitment of presynaptic proteins" EXACT [GOC:TermGenie] synonym: "inhibition of protein localisation in presynapse" NARROW [GOC:TermGenie] synonym: "inhibition of protein localisation to presynapse" NARROW [GOC:TermGenie] synonym: "inhibition of protein localization in presynapse" NARROW [GOC:TermGenie] synonym: "inhibition of protein localization to presynapse" NARROW [GOC:TermGenie] synonym: "inhibition of recruitment of presynaptic proteins" NARROW [GOC:TermGenie] synonym: "negative regulation of protein localisation in presynapse" EXACT [GOC:TermGenie] synonym: "negative regulation of protein localisation to presynapse" EXACT [GOC:TermGenie] synonym: "negative regulation of protein localization in presynapse" EXACT [GOC:TermGenie] synonym: "negative regulation of recruitment of presynaptic proteins" EXACT [GOC:TermGenie] is_a: GO:1903828 ! negative regulation of protein localization is_a: GO:1905384 ! regulation of protein localization to presynapse intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:1905383 ! negatively regulates protein localization to presynapse relationship: RO:0002212 GO:1905383 ! negatively regulates protein localization to presynapse creation_date: 2016-08-18T14:56:08Z [Term] id: GO:1905386 name: positive regulation of protein localization to presynapse namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of protein localization to presynapse." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:24449494] synonym: "activation of protein localisation in presynapse" NARROW [GOC:TermGenie] synonym: "activation of protein localisation to presynapse" NARROW [GOC:TermGenie] synonym: "activation of protein localization in presynapse" NARROW [GOC:TermGenie] synonym: "activation of protein localization to presynapse" NARROW [GOC:TermGenie] synonym: "activation of recruitment of presynaptic proteins" NARROW [GOC:TermGenie] synonym: "positive regulation of protein localisation in presynapse" EXACT [GOC:TermGenie] synonym: "positive regulation of protein localisation to presynapse" EXACT [GOC:TermGenie] synonym: "positive regulation of protein localization in presynapse" EXACT [GOC:TermGenie] synonym: "positive regulation of recruitment of presynaptic proteins" EXACT [GOC:TermGenie] synonym: "up regulation of protein localisation in presynapse" EXACT [GOC:TermGenie] synonym: "up regulation of protein localisation to presynapse" EXACT [GOC:TermGenie] synonym: "up regulation of protein localization in presynapse" EXACT [GOC:TermGenie] synonym: "up regulation of protein localization to presynapse" EXACT [GOC:TermGenie] synonym: "up regulation of recruitment of presynaptic proteins" EXACT [GOC:TermGenie] synonym: "up-regulation of protein localisation in presynapse" EXACT [GOC:TermGenie] synonym: "up-regulation of protein localisation to presynapse" EXACT [GOC:TermGenie] synonym: "up-regulation of protein localization in presynapse" EXACT [GOC:TermGenie] synonym: "up-regulation of protein localization to presynapse" EXACT [GOC:TermGenie] synonym: "up-regulation of recruitment of presynaptic proteins" EXACT [GOC:TermGenie] synonym: "upregulation of protein localisation in presynapse" EXACT [GOC:TermGenie] synonym: "upregulation of protein localisation to presynapse" EXACT [GOC:TermGenie] synonym: "upregulation of protein localization in presynapse" EXACT [GOC:TermGenie] synonym: "upregulation of protein localization to presynapse" EXACT [GOC:TermGenie] synonym: "upregulation of recruitment of presynaptic proteins" EXACT [GOC:TermGenie] is_a: GO:1902474 ! positive regulation of protein localization to synapse is_a: GO:1905384 ! regulation of protein localization to presynapse intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:1905383 ! positively regulates protein localization to presynapse relationship: RO:0002213 GO:1905383 ! positively regulates protein localization to presynapse creation_date: 2016-08-18T14:56:21Z [Term] id: GO:1905397 name: activated CD8-positive, alpha-beta T cell apoptotic process namespace: biological_process def: "Any apoptotic process in an activated CD8-positive, alpha-beta T cell." [GO_REF:0000085, GOC:TermGenie, PMID:24187568] synonym: "activated CD8-positive, alpha-beta T cell apoptosis" NARROW [GOC:TermGenie] synonym: "activated CD8-positive, alpha-beta T lymphocyte apoptosis" NARROW [GOC:TermGenie] synonym: "activated CD8-positive, alpha-beta T lymphocyte apoptotic process" EXACT [GOC:TermGenie] synonym: "activated CD8-positive, alpha-beta T-cell apoptosis" NARROW [GOC:TermGenie] synonym: "activated CD8-positive, alpha-beta T-cell apoptotic process" EXACT [GOC:TermGenie] synonym: "activated CD8-positive, alpha-beta T-lymphocyte apoptosis" NARROW [GOC:TermGenie] synonym: "activated CD8-positive, alpha-beta T-lymphocyte apoptotic process" EXACT [GOC:TermGenie] is_a: GO:0070231 ! T cell apoptotic process intersection_of: GO:0006915 ! apoptotic process intersection_of: BFO:0000066 CL:0000906 ! occurs in activated CD8-positive, alpha-beta T cell relationship: BFO:0000066 CL:0000906 ! occurs in activated CD8-positive, alpha-beta T cell creation_date: 2016-08-25T08:09:27Z [Term] id: GO:1905398 name: activated CD4-positive, alpha-beta T cell apoptotic process namespace: biological_process def: "Any apoptotic process in an activated CD4-positive, alpha-beta T cell." [GO_REF:0000085, GOC:TermGenie, PMID:24187568] synonym: "activated CD4-positive, alpha-beta T cell apoptosis" NARROW [GOC:TermGenie] synonym: "activated CD4-positive, alpha-beta T lymphocyte apoptosis" NARROW [GOC:TermGenie] synonym: "activated CD4-positive, alpha-beta T lymphocyte apoptotic process" EXACT [GOC:TermGenie] synonym: "activated CD4-positive, alpha-beta T-cell apoptosis" NARROW [GOC:TermGenie] synonym: "activated CD4-positive, alpha-beta T-cell apoptotic process" EXACT [GOC:TermGenie] synonym: "activated CD4-positive, alpha-beta T-lymphocyte apoptosis" NARROW [GOC:TermGenie] synonym: "activated CD4-positive, alpha-beta T-lymphocyte apoptotic process" EXACT [GOC:TermGenie] is_a: GO:0070231 ! T cell apoptotic process intersection_of: GO:0006915 ! apoptotic process intersection_of: BFO:0000066 CL:0000896 ! occurs in activated CD4-positive, alpha-beta T cell relationship: BFO:0000066 CL:0000896 ! occurs in activated CD4-positive, alpha-beta T cell creation_date: 2016-08-25T08:13:40Z [Term] id: GO:1905399 name: regulation of activated CD4-positive, alpha-beta T cell apoptotic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of activated CD4-positive, alpha-beta T cell apoptotic process." [GO_REF:0000058, GOC:TermGenie, PMID:24187568] synonym: "regulation of activated CD4-positive, alpha-beta T cell apoptosis" NARROW [GOC:TermGenie] synonym: "regulation of activated CD4-positive, alpha-beta T lymphocyte apoptosis" NARROW [GOC:TermGenie] synonym: "regulation of activated CD4-positive, alpha-beta T lymphocyte apoptotic process" EXACT [GOC:TermGenie] synonym: "regulation of activated CD4-positive, alpha-beta T-cell apoptosis" NARROW [GOC:TermGenie] synonym: "regulation of activated CD4-positive, alpha-beta T-cell apoptotic process" EXACT [GOC:TermGenie] synonym: "regulation of activated CD4-positive, alpha-beta T-lymphocyte apoptosis" NARROW [GOC:TermGenie] synonym: "regulation of activated CD4-positive, alpha-beta T-lymphocyte apoptotic process" EXACT [GOC:TermGenie] is_a: GO:0070232 ! regulation of T cell apoptotic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:1905398 ! regulates activated CD4-positive, alpha-beta T cell apoptotic process relationship: RO:0002211 GO:1905398 ! regulates activated CD4-positive, alpha-beta T cell apoptotic process creation_date: 2016-08-25T09:09:46Z [Term] id: GO:1905400 name: negative regulation of activated CD4-positive, alpha-beta T cell apoptotic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of activated CD4-positive, alpha-beta T cell apoptotic process." [GO_REF:0000058, GOC:TermGenie, PMID:24187568] synonym: "down regulation of activated CD4-positive, alpha-beta T cell apoptosis" NARROW [GOC:TermGenie] synonym: "down regulation of activated CD4-positive, alpha-beta T cell apoptotic process" EXACT [GOC:TermGenie] synonym: "down regulation of activated CD4-positive, alpha-beta T lymphocyte apoptosis" NARROW [GOC:TermGenie] synonym: "down regulation of activated CD4-positive, alpha-beta T lymphocyte apoptotic process" EXACT [GOC:TermGenie] synonym: "down regulation of activated CD4-positive, alpha-beta T-cell apoptosis" NARROW [GOC:TermGenie] synonym: "down regulation of activated CD4-positive, alpha-beta T-cell apoptotic process" EXACT [GOC:TermGenie] synonym: "down regulation of activated CD4-positive, alpha-beta T-lymphocyte apoptosis" NARROW [GOC:TermGenie] synonym: "down regulation of activated CD4-positive, alpha-beta T-lymphocyte apoptotic process" EXACT [GOC:TermGenie] synonym: "down-regulation of activated CD4-positive, alpha-beta T cell apoptosis" NARROW [GOC:TermGenie] synonym: "down-regulation of activated CD4-positive, alpha-beta T cell apoptotic process" EXACT [GOC:TermGenie] synonym: "down-regulation of activated CD4-positive, alpha-beta T lymphocyte apoptosis" NARROW [GOC:TermGenie] synonym: "down-regulation of activated CD4-positive, alpha-beta T lymphocyte apoptotic process" EXACT [GOC:TermGenie] synonym: "down-regulation of activated CD4-positive, alpha-beta T-cell apoptosis" NARROW [GOC:TermGenie] synonym: "down-regulation of activated CD4-positive, alpha-beta T-cell apoptotic process" EXACT [GOC:TermGenie] synonym: "down-regulation of activated CD4-positive, alpha-beta T-lymphocyte apoptosis" NARROW [GOC:TermGenie] synonym: "down-regulation of activated CD4-positive, alpha-beta T-lymphocyte apoptotic process" EXACT [GOC:TermGenie] synonym: "downregulation of activated CD4-positive, alpha-beta T cell apoptosis" NARROW [GOC:TermGenie] synonym: "downregulation of activated CD4-positive, alpha-beta T cell apoptotic process" EXACT [GOC:TermGenie] synonym: "downregulation of activated CD4-positive, alpha-beta T lymphocyte apoptosis" NARROW [GOC:TermGenie] synonym: "downregulation of activated CD4-positive, alpha-beta T lymphocyte apoptotic process" EXACT [GOC:TermGenie] synonym: "downregulation of activated CD4-positive, alpha-beta T-cell apoptosis" NARROW [GOC:TermGenie] synonym: "downregulation of activated CD4-positive, alpha-beta T-cell apoptotic process" EXACT [GOC:TermGenie] synonym: "downregulation of activated CD4-positive, alpha-beta T-lymphocyte apoptosis" NARROW [GOC:TermGenie] synonym: "downregulation of activated CD4-positive, alpha-beta T-lymphocyte apoptotic process" EXACT [GOC:TermGenie] synonym: "inhibition of activated CD4-positive, alpha-beta T cell apoptosis" NARROW [GOC:TermGenie] synonym: "inhibition of activated CD4-positive, alpha-beta T cell apoptotic process" NARROW [GOC:TermGenie] synonym: "inhibition of activated CD4-positive, alpha-beta T lymphocyte apoptosis" NARROW [GOC:TermGenie] synonym: "inhibition of activated CD4-positive, alpha-beta T lymphocyte apoptotic process" NARROW [GOC:TermGenie] synonym: "inhibition of activated CD4-positive, alpha-beta T-cell apoptosis" NARROW [GOC:TermGenie] synonym: "inhibition of activated CD4-positive, alpha-beta T-cell apoptotic process" NARROW [GOC:TermGenie] synonym: "inhibition of activated CD4-positive, alpha-beta T-lymphocyte apoptosis" NARROW [GOC:TermGenie] synonym: "inhibition of activated CD4-positive, alpha-beta T-lymphocyte apoptotic process" NARROW [GOC:TermGenie] synonym: "negative regulation of activated CD4-positive, alpha-beta T cell apoptosis" NARROW [GOC:TermGenie] synonym: "negative regulation of activated CD4-positive, alpha-beta T lymphocyte apoptosis" NARROW [GOC:TermGenie] synonym: "negative regulation of activated CD4-positive, alpha-beta T lymphocyte apoptotic process" EXACT [GOC:TermGenie] synonym: "negative regulation of activated CD4-positive, alpha-beta T-cell apoptosis" NARROW [GOC:TermGenie] synonym: "negative regulation of activated CD4-positive, alpha-beta T-cell apoptotic process" EXACT [GOC:TermGenie] synonym: "negative regulation of activated CD4-positive, alpha-beta T-lymphocyte apoptosis" NARROW [GOC:TermGenie] synonym: "negative regulation of activated CD4-positive, alpha-beta T-lymphocyte apoptotic process" EXACT [GOC:TermGenie] is_a: GO:0070233 ! negative regulation of T cell apoptotic process is_a: GO:1905399 ! regulation of activated CD4-positive, alpha-beta T cell apoptotic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:1905398 ! negatively regulates activated CD4-positive, alpha-beta T cell apoptotic process relationship: RO:0002212 GO:1905398 ! negatively regulates activated CD4-positive, alpha-beta T cell apoptotic process creation_date: 2016-08-25T09:09:53Z [Term] id: GO:1905401 name: positive regulation of activated CD4-positive, alpha-beta T cell apoptotic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of activated CD4-positive, alpha-beta T cell apoptotic process." [GO_REF:0000058, GOC:TermGenie, PMID:24187568] synonym: "activation of activated CD4-positive, alpha-beta T cell apoptosis" NARROW [GOC:TermGenie] synonym: "activation of activated CD4-positive, alpha-beta T cell apoptotic process" NARROW [GOC:TermGenie] synonym: "activation of activated CD4-positive, alpha-beta T lymphocyte apoptosis" NARROW [GOC:TermGenie] synonym: "activation of activated CD4-positive, alpha-beta T lymphocyte apoptotic process" NARROW [GOC:TermGenie] synonym: "activation of activated CD4-positive, alpha-beta T-cell apoptosis" NARROW [GOC:TermGenie] synonym: "activation of activated CD4-positive, alpha-beta T-cell apoptotic process" NARROW [GOC:TermGenie] synonym: "activation of activated CD4-positive, alpha-beta T-lymphocyte apoptosis" NARROW [GOC:TermGenie] synonym: "activation of activated CD4-positive, alpha-beta T-lymphocyte apoptotic process" NARROW [GOC:TermGenie] synonym: "positive regulation of activated CD4-positive, alpha-beta T cell apoptosis" NARROW [GOC:TermGenie] synonym: "positive regulation of activated CD4-positive, alpha-beta T lymphocyte apoptosis" NARROW [GOC:TermGenie] synonym: "positive regulation of activated CD4-positive, alpha-beta T lymphocyte apoptotic process" EXACT [GOC:TermGenie] synonym: "positive regulation of activated CD4-positive, alpha-beta T-cell apoptosis" NARROW [GOC:TermGenie] synonym: "positive regulation of activated CD4-positive, alpha-beta T-cell apoptotic process" EXACT [GOC:TermGenie] synonym: "positive regulation of activated CD4-positive, alpha-beta T-lymphocyte apoptosis" NARROW [GOC:TermGenie] synonym: "positive regulation of activated CD4-positive, alpha-beta T-lymphocyte apoptotic process" EXACT [GOC:TermGenie] synonym: "up regulation of activated CD4-positive, alpha-beta T cell apoptosis" NARROW [GOC:TermGenie] synonym: "up regulation of activated CD4-positive, alpha-beta T cell apoptotic process" EXACT [GOC:TermGenie] synonym: "up regulation of activated CD4-positive, alpha-beta T lymphocyte apoptosis" NARROW [GOC:TermGenie] synonym: "up regulation of activated CD4-positive, alpha-beta T lymphocyte apoptotic process" EXACT [GOC:TermGenie] synonym: "up regulation of activated CD4-positive, alpha-beta T-cell apoptosis" NARROW [GOC:TermGenie] synonym: "up regulation of activated CD4-positive, alpha-beta T-cell apoptotic process" EXACT [GOC:TermGenie] synonym: "up regulation of activated CD4-positive, alpha-beta T-lymphocyte apoptosis" NARROW [GOC:TermGenie] synonym: "up regulation of activated CD4-positive, alpha-beta T-lymphocyte apoptotic process" EXACT [GOC:TermGenie] synonym: "up-regulation of activated CD4-positive, alpha-beta T cell apoptosis" NARROW [GOC:TermGenie] synonym: "up-regulation of activated CD4-positive, alpha-beta T cell apoptotic process" EXACT [GOC:TermGenie] synonym: "up-regulation of activated CD4-positive, alpha-beta T lymphocyte apoptosis" NARROW [GOC:TermGenie] synonym: "up-regulation of activated CD4-positive, alpha-beta T lymphocyte apoptotic process" EXACT [GOC:TermGenie] synonym: "up-regulation of activated CD4-positive, alpha-beta T-cell apoptosis" NARROW [GOC:TermGenie] synonym: "up-regulation of activated CD4-positive, alpha-beta T-cell apoptotic process" EXACT [GOC:TermGenie] synonym: "up-regulation of activated CD4-positive, alpha-beta T-lymphocyte apoptosis" NARROW [GOC:TermGenie] synonym: "up-regulation of activated CD4-positive, alpha-beta T-lymphocyte apoptotic process" EXACT [GOC:TermGenie] synonym: "upregulation of activated CD4-positive, alpha-beta T cell apoptosis" NARROW [GOC:TermGenie] synonym: "upregulation of activated CD4-positive, alpha-beta T cell apoptotic process" EXACT [GOC:TermGenie] synonym: "upregulation of activated CD4-positive, alpha-beta T lymphocyte apoptosis" NARROW [GOC:TermGenie] synonym: "upregulation of activated CD4-positive, alpha-beta T lymphocyte apoptotic process" EXACT [GOC:TermGenie] synonym: "upregulation of activated CD4-positive, alpha-beta T-cell apoptosis" NARROW [GOC:TermGenie] synonym: "upregulation of activated CD4-positive, alpha-beta T-cell apoptotic process" EXACT [GOC:TermGenie] synonym: "upregulation of activated CD4-positive, alpha-beta T-lymphocyte apoptosis" NARROW [GOC:TermGenie] synonym: "upregulation of activated CD4-positive, alpha-beta T-lymphocyte apoptotic process" EXACT [GOC:TermGenie] is_a: GO:0070234 ! positive regulation of T cell apoptotic process is_a: GO:1905399 ! regulation of activated CD4-positive, alpha-beta T cell apoptotic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:1905398 ! positively regulates activated CD4-positive, alpha-beta T cell apoptotic process relationship: RO:0002213 GO:1905398 ! positively regulates activated CD4-positive, alpha-beta T cell apoptotic process creation_date: 2016-08-25T09:10:00Z [Term] id: GO:1905402 name: regulation of activated CD8-positive, alpha-beta T cell apoptotic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of activated CD8-positive, alpha-beta T cell apoptotic process." [GO_REF:0000058, GOC:TermGenie, PMID:24187568] synonym: "regulation of activated CD8-positive, alpha-beta T cell apoptosis" NARROW [GOC:TermGenie] synonym: "regulation of activated CD8-positive, alpha-beta T lymphocyte apoptosis" NARROW [GOC:TermGenie] synonym: "regulation of activated CD8-positive, alpha-beta T lymphocyte apoptotic process" EXACT [GOC:TermGenie] synonym: "regulation of activated CD8-positive, alpha-beta T-cell apoptosis" NARROW [GOC:TermGenie] synonym: "regulation of activated CD8-positive, alpha-beta T-cell apoptotic process" EXACT [GOC:TermGenie] synonym: "regulation of activated CD8-positive, alpha-beta T-lymphocyte apoptosis" NARROW [GOC:TermGenie] synonym: "regulation of activated CD8-positive, alpha-beta T-lymphocyte apoptotic process" EXACT [GOC:TermGenie] is_a: GO:0070232 ! regulation of T cell apoptotic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:1905397 ! regulates activated CD8-positive, alpha-beta T cell apoptotic process relationship: RO:0002211 GO:1905397 ! regulates activated CD8-positive, alpha-beta T cell apoptotic process creation_date: 2016-08-25T09:13:56Z [Term] id: GO:1905403 name: negative regulation of activated CD8-positive, alpha-beta T cell apoptotic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of activated CD8-positive, alpha-beta T cell apoptotic process." [GO_REF:0000058, GOC:TermGenie, PMID:24187568] synonym: "down regulation of activated CD8-positive, alpha-beta T cell apoptosis" NARROW [GOC:TermGenie] synonym: "down regulation of activated CD8-positive, alpha-beta T cell apoptotic process" EXACT [GOC:TermGenie] synonym: "down regulation of activated CD8-positive, alpha-beta T lymphocyte apoptosis" NARROW [GOC:TermGenie] synonym: "down regulation of activated CD8-positive, alpha-beta T lymphocyte apoptotic process" EXACT [GOC:TermGenie] synonym: "down regulation of activated CD8-positive, alpha-beta T-cell apoptosis" NARROW [GOC:TermGenie] synonym: "down regulation of activated CD8-positive, alpha-beta T-cell apoptotic process" EXACT [GOC:TermGenie] synonym: "down regulation of activated CD8-positive, alpha-beta T-lymphocyte apoptosis" NARROW [GOC:TermGenie] synonym: "down regulation of activated CD8-positive, alpha-beta T-lymphocyte apoptotic process" EXACT [GOC:TermGenie] synonym: "down-regulation of activated CD8-positive, alpha-beta T cell apoptosis" NARROW [GOC:TermGenie] synonym: "down-regulation of activated CD8-positive, alpha-beta T cell apoptotic process" EXACT [GOC:TermGenie] synonym: "down-regulation of activated CD8-positive, alpha-beta T lymphocyte apoptosis" NARROW [GOC:TermGenie] synonym: "down-regulation of activated CD8-positive, alpha-beta T lymphocyte apoptotic process" EXACT [GOC:TermGenie] synonym: "down-regulation of activated CD8-positive, alpha-beta T-cell apoptosis" NARROW [GOC:TermGenie] synonym: "down-regulation of activated CD8-positive, alpha-beta T-cell apoptotic process" EXACT [GOC:TermGenie] synonym: "down-regulation of activated CD8-positive, alpha-beta T-lymphocyte apoptosis" NARROW [GOC:TermGenie] synonym: "down-regulation of activated CD8-positive, alpha-beta T-lymphocyte apoptotic process" EXACT [GOC:TermGenie] synonym: "downregulation of activated CD8-positive, alpha-beta T cell apoptosis" NARROW [GOC:TermGenie] synonym: "downregulation of activated CD8-positive, alpha-beta T cell apoptotic process" EXACT [GOC:TermGenie] synonym: "downregulation of activated CD8-positive, alpha-beta T lymphocyte apoptosis" NARROW [GOC:TermGenie] synonym: "downregulation of activated CD8-positive, alpha-beta T lymphocyte apoptotic process" EXACT [GOC:TermGenie] synonym: "downregulation of activated CD8-positive, alpha-beta T-cell apoptosis" NARROW [GOC:TermGenie] synonym: "downregulation of activated CD8-positive, alpha-beta T-cell apoptotic process" EXACT [GOC:TermGenie] synonym: "downregulation of activated CD8-positive, alpha-beta T-lymphocyte apoptosis" NARROW [GOC:TermGenie] synonym: "downregulation of activated CD8-positive, alpha-beta T-lymphocyte apoptotic process" EXACT [GOC:TermGenie] synonym: "inhibition of activated CD8-positive, alpha-beta T cell apoptosis" NARROW [GOC:TermGenie] synonym: "inhibition of activated CD8-positive, alpha-beta T cell apoptotic process" NARROW [GOC:TermGenie] synonym: "inhibition of activated CD8-positive, alpha-beta T lymphocyte apoptosis" NARROW [GOC:TermGenie] synonym: "inhibition of activated CD8-positive, alpha-beta T lymphocyte apoptotic process" NARROW [GOC:TermGenie] synonym: "inhibition of activated CD8-positive, alpha-beta T-cell apoptosis" NARROW [GOC:TermGenie] synonym: "inhibition of activated CD8-positive, alpha-beta T-cell apoptotic process" NARROW [GOC:TermGenie] synonym: "inhibition of activated CD8-positive, alpha-beta T-lymphocyte apoptosis" NARROW [GOC:TermGenie] synonym: "inhibition of activated CD8-positive, alpha-beta T-lymphocyte apoptotic process" NARROW [GOC:TermGenie] synonym: "negative regulation of activated CD8-positive, alpha-beta T cell apoptosis" NARROW [GOC:TermGenie] synonym: "negative regulation of activated CD8-positive, alpha-beta T lymphocyte apoptosis" NARROW [GOC:TermGenie] synonym: "negative regulation of activated CD8-positive, alpha-beta T lymphocyte apoptotic process" EXACT [GOC:TermGenie] synonym: "negative regulation of activated CD8-positive, alpha-beta T-cell apoptosis" NARROW [GOC:TermGenie] synonym: "negative regulation of activated CD8-positive, alpha-beta T-cell apoptotic process" EXACT [GOC:TermGenie] synonym: "negative regulation of activated CD8-positive, alpha-beta T-lymphocyte apoptosis" NARROW [GOC:TermGenie] synonym: "negative regulation of activated CD8-positive, alpha-beta T-lymphocyte apoptotic process" EXACT [GOC:TermGenie] is_a: GO:0070233 ! negative regulation of T cell apoptotic process is_a: GO:1905402 ! regulation of activated CD8-positive, alpha-beta T cell apoptotic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:1905397 ! negatively regulates activated CD8-positive, alpha-beta T cell apoptotic process relationship: RO:0002212 GO:1905397 ! negatively regulates activated CD8-positive, alpha-beta T cell apoptotic process creation_date: 2016-08-25T09:14:03Z [Term] id: GO:1905404 name: positive regulation of activated CD8-positive, alpha-beta T cell apoptotic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of activated CD8-positive, alpha-beta T cell apoptotic process." [GO_REF:0000058, GOC:TermGenie, PMID:24187568] synonym: "activation of activated CD8-positive, alpha-beta T cell apoptosis" NARROW [GOC:TermGenie] synonym: "activation of activated CD8-positive, alpha-beta T cell apoptotic process" NARROW [GOC:TermGenie] synonym: "activation of activated CD8-positive, alpha-beta T lymphocyte apoptosis" NARROW [GOC:TermGenie] synonym: "activation of activated CD8-positive, alpha-beta T lymphocyte apoptotic process" NARROW [GOC:TermGenie] synonym: "activation of activated CD8-positive, alpha-beta T-cell apoptosis" NARROW [GOC:TermGenie] synonym: "activation of activated CD8-positive, alpha-beta T-cell apoptotic process" NARROW [GOC:TermGenie] synonym: "activation of activated CD8-positive, alpha-beta T-lymphocyte apoptosis" NARROW [GOC:TermGenie] synonym: "activation of activated CD8-positive, alpha-beta T-lymphocyte apoptotic process" NARROW [GOC:TermGenie] synonym: "positive regulation of activated CD8-positive, alpha-beta T cell apoptosis" NARROW [GOC:TermGenie] synonym: "positive regulation of activated CD8-positive, alpha-beta T lymphocyte apoptosis" NARROW [GOC:TermGenie] synonym: "positive regulation of activated CD8-positive, alpha-beta T lymphocyte apoptotic process" EXACT [GOC:TermGenie] synonym: "positive regulation of activated CD8-positive, alpha-beta T-cell apoptosis" NARROW [GOC:TermGenie] synonym: "positive regulation of activated CD8-positive, alpha-beta T-cell apoptotic process" EXACT [GOC:TermGenie] synonym: "positive regulation of activated CD8-positive, alpha-beta T-lymphocyte apoptosis" NARROW [GOC:TermGenie] synonym: "positive regulation of activated CD8-positive, alpha-beta T-lymphocyte apoptotic process" EXACT [GOC:TermGenie] synonym: "up regulation of activated CD8-positive, alpha-beta T cell apoptosis" NARROW [GOC:TermGenie] synonym: "up regulation of activated CD8-positive, alpha-beta T cell apoptotic process" EXACT [GOC:TermGenie] synonym: "up regulation of activated CD8-positive, alpha-beta T lymphocyte apoptosis" NARROW [GOC:TermGenie] synonym: "up regulation of activated CD8-positive, alpha-beta T lymphocyte apoptotic process" EXACT [GOC:TermGenie] synonym: "up regulation of activated CD8-positive, alpha-beta T-cell apoptosis" NARROW [GOC:TermGenie] synonym: "up regulation of activated CD8-positive, alpha-beta T-cell apoptotic process" EXACT [GOC:TermGenie] synonym: "up regulation of activated CD8-positive, alpha-beta T-lymphocyte apoptosis" NARROW [GOC:TermGenie] synonym: "up regulation of activated CD8-positive, alpha-beta T-lymphocyte apoptotic process" EXACT [GOC:TermGenie] synonym: "up-regulation of activated CD8-positive, alpha-beta T cell apoptosis" NARROW [GOC:TermGenie] synonym: "up-regulation of activated CD8-positive, alpha-beta T cell apoptotic process" EXACT [GOC:TermGenie] synonym: "up-regulation of activated CD8-positive, alpha-beta T lymphocyte apoptosis" NARROW [GOC:TermGenie] synonym: "up-regulation of activated CD8-positive, alpha-beta T lymphocyte apoptotic process" EXACT [GOC:TermGenie] synonym: "up-regulation of activated CD8-positive, alpha-beta T-cell apoptosis" NARROW [GOC:TermGenie] synonym: "up-regulation of activated CD8-positive, alpha-beta T-cell apoptotic process" EXACT [GOC:TermGenie] synonym: "up-regulation of activated CD8-positive, alpha-beta T-lymphocyte apoptosis" NARROW [GOC:TermGenie] synonym: "up-regulation of activated CD8-positive, alpha-beta T-lymphocyte apoptotic process" EXACT [GOC:TermGenie] synonym: "upregulation of activated CD8-positive, alpha-beta T cell apoptosis" NARROW [GOC:TermGenie] synonym: "upregulation of activated CD8-positive, alpha-beta T cell apoptotic process" EXACT [GOC:TermGenie] synonym: "upregulation of activated CD8-positive, alpha-beta T lymphocyte apoptosis" NARROW [GOC:TermGenie] synonym: "upregulation of activated CD8-positive, alpha-beta T lymphocyte apoptotic process" EXACT [GOC:TermGenie] synonym: "upregulation of activated CD8-positive, alpha-beta T-cell apoptosis" NARROW [GOC:TermGenie] synonym: "upregulation of activated CD8-positive, alpha-beta T-cell apoptotic process" EXACT [GOC:TermGenie] synonym: "upregulation of activated CD8-positive, alpha-beta T-lymphocyte apoptosis" NARROW [GOC:TermGenie] synonym: "upregulation of activated CD8-positive, alpha-beta T-lymphocyte apoptotic process" EXACT [GOC:TermGenie] is_a: GO:0070234 ! positive regulation of T cell apoptotic process is_a: GO:1905402 ! regulation of activated CD8-positive, alpha-beta T cell apoptotic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:1905397 ! positively regulates activated CD8-positive, alpha-beta T cell apoptotic process relationship: RO:0002213 GO:1905397 ! positively regulates activated CD8-positive, alpha-beta T cell apoptotic process creation_date: 2016-08-25T09:14:10Z [Term] id: GO:1905413 name: regulation of dense core granule exocytosis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of dense core granule exocytosis." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:18468511] synonym: "regulation of dense core vesicle exocytosis" EXACT [GOC:TermGenie] is_a: GO:0017158 ! regulation of calcium ion-dependent exocytosis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:1990504 ! regulates dense core granule exocytosis relationship: BFO:0000066 GO:0098793 ! occurs in presynapse relationship: RO:0002211 GO:1990504 ! regulates dense core granule exocytosis creation_date: 2016-08-31T08:02:21Z [Term] id: GO:1905414 name: negative regulation of dense core granule exocytosis namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of dense core granule exocytosis." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie] synonym: "down regulation of dense core granule exocytosis" EXACT [GOC:TermGenie] synonym: "down regulation of dense core vesicle exocytosis" EXACT [GOC:TermGenie] synonym: "down-regulation of dense core granule exocytosis" EXACT [GOC:TermGenie] synonym: "down-regulation of dense core vesicle exocytosis" EXACT [GOC:TermGenie] synonym: "downregulation of dense core granule exocytosis" EXACT [GOC:TermGenie] synonym: "downregulation of dense core vesicle exocytosis" EXACT [GOC:TermGenie] synonym: "inhibition of dense core granule exocytosis" NARROW [GOC:TermGenie] synonym: "inhibition of dense core vesicle exocytosis" NARROW [GOC:TermGenie] synonym: "negative regulation of dense core vesicle exocytosis" EXACT [GOC:TermGenie] is_a: GO:0045955 ! negative regulation of calcium ion-dependent exocytosis is_a: GO:1905413 ! regulation of dense core granule exocytosis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:1990504 ! negatively regulates dense core granule exocytosis relationship: RO:0002212 GO:1990504 ! negatively regulates dense core granule exocytosis creation_date: 2016-08-31T08:02:28Z [Term] id: GO:1905415 name: positive regulation of dense core granule exocytosis namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of dense core granule exocytosis." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:18468511] synonym: "activation of dense core granule exocytosis" NARROW [GOC:TermGenie] synonym: "activation of dense core vesicle exocytosis" NARROW [GOC:TermGenie] synonym: "positive regulation of dense core vesicle exocytosis" EXACT [GOC:TermGenie] synonym: "up regulation of dense core granule exocytosis" EXACT [GOC:TermGenie] synonym: "up regulation of dense core vesicle exocytosis" EXACT [GOC:TermGenie] synonym: "up-regulation of dense core granule exocytosis" EXACT [GOC:TermGenie] synonym: "up-regulation of dense core vesicle exocytosis" EXACT [GOC:TermGenie] synonym: "upregulation of dense core granule exocytosis" EXACT [GOC:TermGenie] synonym: "upregulation of dense core vesicle exocytosis" EXACT [GOC:TermGenie] is_a: GO:0045956 ! positive regulation of calcium ion-dependent exocytosis is_a: GO:1905413 ! regulation of dense core granule exocytosis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:1990504 ! positively regulates dense core granule exocytosis relationship: RO:0002213 GO:1990504 ! positively regulates dense core granule exocytosis creation_date: 2016-08-31T08:02:36Z [Term] id: GO:1905429 name: response to glycine namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glycine stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:18984164] synonym: "response to aminoacetic acid" EXACT [] synonym: "response to aminoethanoic acid" EXACT [] synonym: "response to Gly" EXACT [] synonym: "response to glycin" EXACT [] is_a: GO:0043200 ! response to amino acid is_a: GO:1901698 ! response to nitrogen compound is_a: GO:1901700 ! response to oxygen-containing compound intersection_of: GO:0050896 ! response to stimulus intersection_of: RO:0004009 CHEBI:57305 ! has primary input relationship: RO:0004009 CHEBI:57305 ! has primary input creation_date: 2016-09-08T22:09:15Z [Term] id: GO:1905430 name: cellular response to glycine namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glycine stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:18984164] synonym: "cellular response to aminoacetic acid" EXACT [] synonym: "cellular response to aminoethanoic acid" EXACT [] synonym: "cellular response to Gly" EXACT [] synonym: "cellular response to glycin" EXACT [] is_a: GO:0071230 ! cellular response to amino acid stimulus is_a: GO:1901699 ! cellular response to nitrogen compound is_a: GO:1901701 ! cellular response to oxygen-containing compound is_a: GO:1905429 ! response to glycine intersection_of: GO:0070887 ! cellular response to chemical stimulus intersection_of: RO:0004009 CHEBI:57305 ! has primary input creation_date: 2016-09-08T22:09:23Z [Term] id: GO:1905432 name: regulation of retrograde trans-synaptic signaling by neuropeptide namespace: biological_process def: "Any process that modulates the frequency, rate or extent of retrograde trans-synaptic signaling by neuropeptide." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:19448629] synonym: "regulation of neuropeptide-mediated retrograde trans-synaptic signaling" RELATED [GOC:bf] is_a: GO:0099177 ! regulation of trans-synaptic signaling intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0099082 ! regulates retrograde trans-synaptic signaling by neuropeptide relationship: RO:0002211 GO:0099082 ! regulates retrograde trans-synaptic signaling by neuropeptide creation_date: 2016-09-14T10:56:47Z [Term] id: GO:1905433 name: negative regulation of retrograde trans-synaptic signaling by neuropeptide namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of retrograde trans-synaptic signaling by neuropeptide." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:19448629] synonym: "down regulation of retrograde trans-synaptic signaling by neuropeptide" EXACT [GOC:TermGenie] synonym: "down-regulation of retrograde trans-synaptic signaling by neuropeptide" EXACT [GOC:TermGenie] synonym: "downregulation of retrograde trans-synaptic signaling by neuropeptide" EXACT [GOC:TermGenie] synonym: "inhibition of neuropeptide-mediated retrograde trans-synaptic signaling" RELATED [GOC:bf] synonym: "inhibition of retrograde trans-synaptic signaling by neuropeptide" NARROW [GOC:TermGenie] synonym: "negative regulation of neuropeptide-mediated retrograde trans-synaptic signaling" RELATED [GOC:bf] is_a: GO:0010648 ! negative regulation of cell communication is_a: GO:0023057 ! negative regulation of signaling is_a: GO:1905432 ! regulation of retrograde trans-synaptic signaling by neuropeptide intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0099082 ! negatively regulates retrograde trans-synaptic signaling by neuropeptide relationship: RO:0002212 GO:0099082 ! negatively regulates retrograde trans-synaptic signaling by neuropeptide creation_date: 2016-09-14T10:56:55Z [Term] id: GO:1905434 name: positive regulation of retrograde trans-synaptic signaling by neuropeptide namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of retrograde trans-synaptic signaling by neuropeptide." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:19448629] synonym: "activation of retrograde trans-synaptic signaling by neuropeptide" NARROW [GOC:TermGenie] synonym: "positive regulation of neuropeptide-mediated retrograde trans-synaptic signaling" RELATED [GOC:bf] synonym: "up regulation of retrograde trans-synaptic signaling by neuropeptide" EXACT [GOC:TermGenie] synonym: "up-regulation of retrograde trans-synaptic signaling by neuropeptide" EXACT [GOC:TermGenie] synonym: "upregulation of retrograde trans-synaptic signaling by neuropeptide" EXACT [GOC:TermGenie] is_a: GO:0010647 ! positive regulation of cell communication is_a: GO:0023056 ! positive regulation of signaling is_a: GO:1905432 ! regulation of retrograde trans-synaptic signaling by neuropeptide intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0099082 ! positively regulates retrograde trans-synaptic signaling by neuropeptide relationship: RO:0002213 GO:0099082 ! positively regulates retrograde trans-synaptic signaling by neuropeptide creation_date: 2016-09-14T10:57:02Z [Term] id: GO:1905453 name: regulation of myeloid progenitor cell differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of myeloid progenitor cell differentiation." [GO_REF:0000058, GOC:TermGenie, PMID:27010503] is_a: GO:1901532 ! regulation of hematopoietic progenitor cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0002318 ! regulates myeloid progenitor cell differentiation relationship: RO:0002211 GO:0002318 ! regulates myeloid progenitor cell differentiation creation_date: 2016-09-16T12:32:18Z [Term] id: GO:1905454 name: negative regulation of myeloid progenitor cell differentiation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of myeloid progenitor cell differentiation." [GO_REF:0000058, GOC:TermGenie, PMID:27010503] synonym: "down regulation of myeloid progenitor cell differentiation" EXACT [GOC:TermGenie] synonym: "down-regulation of myeloid progenitor cell differentiation" EXACT [GOC:TermGenie] synonym: "downregulation of myeloid progenitor cell differentiation" EXACT [GOC:TermGenie] synonym: "inhibition of myeloid progenitor cell differentiation" NARROW [GOC:TermGenie] is_a: GO:1901533 ! negative regulation of hematopoietic progenitor cell differentiation is_a: GO:1905453 ! regulation of myeloid progenitor cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0002318 ! negatively regulates myeloid progenitor cell differentiation relationship: RO:0002212 GO:0002318 ! negatively regulates myeloid progenitor cell differentiation creation_date: 2016-09-16T12:32:26Z [Term] id: GO:1905455 name: positive regulation of myeloid progenitor cell differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of myeloid progenitor cell differentiation." [GO_REF:0000058, GOC:TermGenie, PMID:27010503] synonym: "activation of myeloid progenitor cell differentiation" NARROW [GOC:TermGenie] synonym: "up regulation of myeloid progenitor cell differentiation" EXACT [GOC:TermGenie] synonym: "up-regulation of myeloid progenitor cell differentiation" EXACT [GOC:TermGenie] synonym: "upregulation of myeloid progenitor cell differentiation" EXACT [GOC:TermGenie] is_a: GO:1901534 ! positive regulation of hematopoietic progenitor cell differentiation is_a: GO:1905453 ! regulation of myeloid progenitor cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0002318 ! positively regulates myeloid progenitor cell differentiation relationship: RO:0002213 GO:0002318 ! positively regulates myeloid progenitor cell differentiation creation_date: 2016-09-16T12:32:33Z [Term] id: GO:1905456 name: regulation of lymphoid progenitor cell differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of lymphoid progenitor cell differentiation." [GO_REF:0000058, GOC:TermGenie, PMID:27010503] is_a: GO:1901532 ! regulation of hematopoietic progenitor cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0002320 ! regulates lymphoid progenitor cell differentiation relationship: RO:0002211 GO:0002320 ! regulates lymphoid progenitor cell differentiation creation_date: 2016-09-16T12:32:40Z [Term] id: GO:1905457 name: negative regulation of lymphoid progenitor cell differentiation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of lymphoid progenitor cell differentiation." [GO_REF:0000058, GOC:TermGenie, PMID:27010503] synonym: "down regulation of lymphoid progenitor cell differentiation" EXACT [GOC:TermGenie] synonym: "down-regulation of lymphoid progenitor cell differentiation" EXACT [GOC:TermGenie] synonym: "downregulation of lymphoid progenitor cell differentiation" EXACT [GOC:TermGenie] synonym: "inhibition of lymphoid progenitor cell differentiation" NARROW [GOC:TermGenie] is_a: GO:1901533 ! negative regulation of hematopoietic progenitor cell differentiation is_a: GO:1905456 ! regulation of lymphoid progenitor cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0002320 ! negatively regulates lymphoid progenitor cell differentiation relationship: RO:0002212 GO:0002320 ! negatively regulates lymphoid progenitor cell differentiation creation_date: 2016-09-16T12:32:48Z [Term] id: GO:1905458 name: positive regulation of lymphoid progenitor cell differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of lymphoid progenitor cell differentiation." [GO_REF:0000058, GOC:TermGenie, PMID:27010503] synonym: "activation of lymphoid progenitor cell differentiation" NARROW [GOC:TermGenie] synonym: "up regulation of lymphoid progenitor cell differentiation" EXACT [GOC:TermGenie] synonym: "up-regulation of lymphoid progenitor cell differentiation" EXACT [GOC:TermGenie] synonym: "upregulation of lymphoid progenitor cell differentiation" EXACT [GOC:TermGenie] is_a: GO:1901534 ! positive regulation of hematopoietic progenitor cell differentiation is_a: GO:1905456 ! regulation of lymphoid progenitor cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0002320 ! positively regulates lymphoid progenitor cell differentiation relationship: RO:0002213 GO:0002320 ! positively regulates lymphoid progenitor cell differentiation creation_date: 2016-09-16T12:32:55Z [Term] id: GO:1905459 name: regulation of vascular associated smooth muscle cell apoptotic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of vascular associated smooth muscle cell apoptotic process." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:26493107] synonym: "regulation of vascular associated smooth muscle cell apoptosis" NARROW [GOC:TermGenie] synonym: "regulation of vascular smooth muscle cell apoptosis" NARROW [GOC:TermGenie] synonym: "regulation of vascular smooth muscle cell apoptotic process" EXACT [GOC:TermGenie] synonym: "regulation of VSMC apoptosis" NARROW [GOC:TermGenie] synonym: "regulation of VSMC apoptotic process" EXACT [GOC:TermGenie] is_a: GO:0034391 ! regulation of smooth muscle cell apoptotic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:1905288 ! regulates vascular associated smooth muscle cell apoptotic process relationship: RO:0002211 GO:1905288 ! regulates vascular associated smooth muscle cell apoptotic process creation_date: 2016-09-19T11:33:54Z [Term] id: GO:1905460 name: negative regulation of vascular associated smooth muscle cell apoptotic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of vascular associated smooth muscle cell apoptotic process." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:26493107] synonym: "down regulation of vascular associated smooth muscle cell apoptosis" NARROW [GOC:TermGenie] synonym: "down regulation of vascular associated smooth muscle cell apoptotic process" EXACT [GOC:TermGenie] synonym: "down regulation of vascular smooth muscle cell apoptosis" NARROW [GOC:TermGenie] synonym: "down regulation of vascular smooth muscle cell apoptotic process" EXACT [GOC:TermGenie] synonym: "down regulation of VSMC apoptosis" NARROW [GOC:TermGenie] synonym: "down regulation of VSMC apoptotic process" EXACT [GOC:TermGenie] synonym: "down-regulation of vascular associated smooth muscle cell apoptosis" NARROW [GOC:TermGenie] synonym: "down-regulation of vascular associated smooth muscle cell apoptotic process" EXACT [GOC:TermGenie] synonym: "down-regulation of vascular smooth muscle cell apoptosis" NARROW [GOC:TermGenie] synonym: "down-regulation of vascular smooth muscle cell apoptotic process" EXACT [GOC:TermGenie] synonym: "down-regulation of VSMC apoptosis" NARROW [GOC:TermGenie] synonym: "down-regulation of VSMC apoptotic process" EXACT [GOC:TermGenie] synonym: "downregulation of vascular associated smooth muscle cell apoptosis" NARROW [GOC:TermGenie] synonym: "downregulation of vascular associated smooth muscle cell apoptotic process" EXACT [GOC:TermGenie] synonym: "downregulation of vascular smooth muscle cell apoptosis" NARROW [GOC:TermGenie] synonym: "downregulation of vascular smooth muscle cell apoptotic process" EXACT [GOC:TermGenie] synonym: "downregulation of VSMC apoptosis" NARROW [GOC:TermGenie] synonym: "downregulation of VSMC apoptotic process" EXACT [GOC:TermGenie] synonym: "inhibition of vascular associated smooth muscle cell apoptosis" NARROW [GOC:TermGenie] synonym: "inhibition of vascular associated smooth muscle cell apoptotic process" NARROW [GOC:TermGenie] synonym: "inhibition of vascular smooth muscle cell apoptosis" NARROW [GOC:TermGenie] synonym: "inhibition of vascular smooth muscle cell apoptotic process" NARROW [GOC:TermGenie] synonym: "inhibition of VSMC apoptosis" NARROW [GOC:TermGenie] synonym: "inhibition of VSMC apoptotic process" NARROW [GOC:TermGenie] synonym: "negative regulation of vascular associated smooth muscle cell apoptosis" NARROW [GOC:TermGenie] synonym: "negative regulation of vascular smooth muscle cell apoptosis" NARROW [GOC:TermGenie] synonym: "negative regulation of vascular smooth muscle cell apoptotic process" EXACT [GOC:TermGenie] synonym: "negative regulation of VSMC apoptosis" NARROW [GOC:TermGenie] synonym: "negative regulation of VSMC apoptotic process" EXACT [GOC:TermGenie] is_a: GO:0034392 ! negative regulation of smooth muscle cell apoptotic process is_a: GO:1905459 ! regulation of vascular associated smooth muscle cell apoptotic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:1905288 ! negatively regulates vascular associated smooth muscle cell apoptotic process relationship: RO:0002212 GO:1905288 ! negatively regulates vascular associated smooth muscle cell apoptotic process creation_date: 2016-09-19T11:34:03Z [Term] id: GO:1905461 name: positive regulation of vascular associated smooth muscle cell apoptotic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of vascular associated smooth muscle cell apoptotic process." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:26493107] synonym: "activation of vascular associated smooth muscle cell apoptosis" NARROW [GOC:TermGenie] synonym: "activation of vascular associated smooth muscle cell apoptotic process" NARROW [GOC:TermGenie] synonym: "activation of vascular smooth muscle cell apoptosis" NARROW [GOC:TermGenie] synonym: "activation of vascular smooth muscle cell apoptotic process" NARROW [GOC:TermGenie] synonym: "activation of VSMC apoptosis" NARROW [GOC:TermGenie] synonym: "activation of VSMC apoptotic process" NARROW [GOC:TermGenie] synonym: "positive regulation of vascular associated smooth muscle cell apoptosis" NARROW [GOC:TermGenie] synonym: "positive regulation of vascular smooth muscle cell apoptosis" NARROW [GOC:TermGenie] synonym: "positive regulation of vascular smooth muscle cell apoptotic process" EXACT [GOC:TermGenie] synonym: "positive regulation of VSMC apoptosis" NARROW [GOC:TermGenie] synonym: "positive regulation of VSMC apoptotic process" EXACT [GOC:TermGenie] synonym: "up regulation of vascular associated smooth muscle cell apoptosis" NARROW [GOC:TermGenie] synonym: "up regulation of vascular associated smooth muscle cell apoptotic process" EXACT [GOC:TermGenie] synonym: "up regulation of vascular smooth muscle cell apoptosis" NARROW [GOC:TermGenie] synonym: "up regulation of vascular smooth muscle cell apoptotic process" EXACT [GOC:TermGenie] synonym: "up regulation of VSMC apoptosis" NARROW [GOC:TermGenie] synonym: "up regulation of VSMC apoptotic process" EXACT [GOC:TermGenie] synonym: "up-regulation of vascular associated smooth muscle cell apoptosis" NARROW [GOC:TermGenie] synonym: "up-regulation of vascular associated smooth muscle cell apoptotic process" EXACT [GOC:TermGenie] synonym: "up-regulation of vascular smooth muscle cell apoptosis" NARROW [GOC:TermGenie] synonym: "up-regulation of vascular smooth muscle cell apoptotic process" EXACT [GOC:TermGenie] synonym: "up-regulation of VSMC apoptosis" NARROW [GOC:TermGenie] synonym: "up-regulation of VSMC apoptotic process" EXACT [GOC:TermGenie] synonym: "upregulation of vascular associated smooth muscle cell apoptosis" NARROW [GOC:TermGenie] synonym: "upregulation of vascular associated smooth muscle cell apoptotic process" EXACT [GOC:TermGenie] synonym: "upregulation of vascular smooth muscle cell apoptosis" NARROW [GOC:TermGenie] synonym: "upregulation of vascular smooth muscle cell apoptotic process" EXACT [GOC:TermGenie] synonym: "upregulation of VSMC apoptosis" NARROW [GOC:TermGenie] synonym: "upregulation of VSMC apoptotic process" EXACT [GOC:TermGenie] is_a: GO:0034393 ! positive regulation of smooth muscle cell apoptotic process is_a: GO:1905459 ! regulation of vascular associated smooth muscle cell apoptotic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:1905288 ! positively regulates vascular associated smooth muscle cell apoptotic process relationship: RO:0002213 GO:1905288 ! positively regulates vascular associated smooth muscle cell apoptotic process creation_date: 2016-09-19T11:34:10Z [Term] id: GO:1905475 name: regulation of protein localization to membrane namespace: biological_process def: "Any process that modulates the frequency, rate or extent of protein localization to membrane." [GO_REF:0000058, GOC:bc, GOC:PARL, GOC:TermGenie, PMID:26911690] synonym: "regulation of protein localisation in membrane" EXACT [GOC:TermGenie] synonym: "regulation of protein localization in membrane" EXACT [GOC:TermGenie] is_a: GO:0032880 ! regulation of protein localization is_a: GO:0060341 ! regulation of cellular localization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0072657 ! regulates protein localization to membrane relationship: RO:0002211 GO:0072657 ! regulates protein localization to membrane creation_date: 2016-09-21T16:20:03Z [Term] id: GO:1905476 name: negative regulation of protein localization to membrane namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to membrane." [GO_REF:0000058, GOC:bc, GOC:PARL, GOC:TermGenie, PMID:26911690] synonym: "down regulation of protein localisation in membrane" EXACT [GOC:TermGenie] synonym: "down regulation of protein localization in membrane" EXACT [GOC:TermGenie] synonym: "down regulation of protein localization to membrane" EXACT [GOC:TermGenie] synonym: "down-regulation of protein localisation in membrane" EXACT [GOC:TermGenie] synonym: "down-regulation of protein localization in membrane" EXACT [GOC:TermGenie] synonym: "down-regulation of protein localization to membrane" EXACT [GOC:TermGenie] synonym: "downregulation of protein localisation in membrane" EXACT [GOC:TermGenie] synonym: "downregulation of protein localization in membrane" EXACT [GOC:TermGenie] synonym: "downregulation of protein localization to membrane" EXACT [GOC:TermGenie] synonym: "inhibition of protein localisation in membrane" NARROW [GOC:TermGenie] synonym: "inhibition of protein localization in membrane" NARROW [GOC:TermGenie] synonym: "inhibition of protein localization to membrane" NARROW [GOC:TermGenie] synonym: "negative regulation of protein localisation in membrane" EXACT [GOC:TermGenie] synonym: "negative regulation of protein localization in membrane" EXACT [GOC:TermGenie] is_a: GO:0048523 ! negative regulation of cellular process is_a: GO:1903828 ! negative regulation of protein localization is_a: GO:1905475 ! regulation of protein localization to membrane intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0072657 ! negatively regulates protein localization to membrane relationship: RO:0002212 GO:0072657 ! negatively regulates protein localization to membrane creation_date: 2016-09-21T16:20:10Z [Term] id: GO:1905477 name: positive regulation of protein localization to membrane namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of protein localization to membrane." [GO_REF:0000058, GOC:bc, GOC:PARL, GOC:TermGenie, PMID:26911690] synonym: "activation of protein localisation in membrane" NARROW [GOC:TermGenie] synonym: "activation of protein localization in membrane" NARROW [GOC:TermGenie] synonym: "activation of protein localization to membrane" NARROW [GOC:TermGenie] synonym: "positive regulation of protein localisation in membrane" EXACT [GOC:TermGenie] synonym: "positive regulation of protein localization in membrane" EXACT [GOC:TermGenie] synonym: "up regulation of protein localisation in membrane" EXACT [GOC:TermGenie] synonym: "up regulation of protein localization in membrane" EXACT [GOC:TermGenie] synonym: "up regulation of protein localization to membrane" EXACT [GOC:TermGenie] synonym: "up-regulation of protein localisation in membrane" EXACT [GOC:TermGenie] synonym: "up-regulation of protein localization in membrane" EXACT [GOC:TermGenie] synonym: "up-regulation of protein localization to membrane" EXACT [GOC:TermGenie] synonym: "upregulation of protein localisation in membrane" EXACT [GOC:TermGenie] synonym: "upregulation of protein localization in membrane" EXACT [GOC:TermGenie] synonym: "upregulation of protein localization to membrane" EXACT [GOC:TermGenie] is_a: GO:0048522 ! positive regulation of cellular process is_a: GO:1903829 ! positive regulation of protein localization is_a: GO:1905475 ! regulation of protein localization to membrane intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0072657 ! positively regulates protein localization to membrane relationship: RO:0002213 GO:0072657 ! positively regulates protein localization to membrane creation_date: 2016-09-21T16:20:18Z [Term] id: GO:1905483 name: regulation of motor neuron migration namespace: biological_process def: "Any process that modulates the frequency, rate or extent of motor neuron migration." [GO_REF:0000058, GOC:TermGenie, PMID:16516839] is_a: GO:2001222 ! regulation of neuron migration intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0097475 ! regulates motor neuron migration relationship: RO:0002211 GO:0097475 ! regulates motor neuron migration creation_date: 2016-09-23T12:49:54Z [Term] id: GO:1905484 name: negative regulation of motor neuron migration namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of motor neuron migration." [GO_REF:0000058, GOC:TermGenie, PMID:16516839] synonym: "down regulation of motor neuron migration" EXACT [GOC:TermGenie] synonym: "down-regulation of motor neuron migration" EXACT [GOC:TermGenie] synonym: "downregulation of motor neuron migration" EXACT [GOC:TermGenie] synonym: "inhibition of motor neuron migration" NARROW [GOC:TermGenie] is_a: GO:1905483 ! regulation of motor neuron migration is_a: GO:2001223 ! negative regulation of neuron migration intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0097475 ! negatively regulates motor neuron migration relationship: RO:0002212 GO:0097475 ! negatively regulates motor neuron migration creation_date: 2016-09-23T12:50:11Z [Term] id: GO:1905485 name: positive regulation of motor neuron migration namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of motor neuron migration." [GO_REF:0000058, GOC:TermGenie, PMID:16516839] synonym: "activation of motor neuron migration" NARROW [GOC:TermGenie] synonym: "up regulation of motor neuron migration" EXACT [GOC:TermGenie] synonym: "up-regulation of motor neuron migration" EXACT [GOC:TermGenie] synonym: "upregulation of motor neuron migration" EXACT [GOC:TermGenie] is_a: GO:1905483 ! regulation of motor neuron migration is_a: GO:2001224 ! positive regulation of neuron migration intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0097475 ! positively regulates motor neuron migration relationship: RO:0002213 GO:0097475 ! positively regulates motor neuron migration creation_date: 2016-09-23T12:50:19Z [Term] id: GO:1905492 name: positive regulation of branching morphogenesis of a nerve namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of branching morphogenesis of a nerve." [GO_REF:0000058, GOC:TermGenie, PMID:16516839] synonym: "activation of branching morphogenesis of a nerve" NARROW [GOC:TermGenie] synonym: "up regulation of branching morphogenesis of a nerve" EXACT [GOC:TermGenie] synonym: "up-regulation of branching morphogenesis of a nerve" EXACT [GOC:TermGenie] synonym: "upregulation of branching morphogenesis of a nerve" EXACT [GOC:TermGenie] is_a: GO:0051094 ! positive regulation of developmental process is_a: GO:0051240 ! positive regulation of multicellular organismal process is_a: GO:2000172 ! regulation of branching morphogenesis of a nerve intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0048755 ! positively regulates branching morphogenesis of a nerve relationship: RO:0002213 GO:0048755 ! positively regulates branching morphogenesis of a nerve creation_date: 2016-09-23T14:11:52Z [Term] id: GO:1905503 name: regulation of motile cilium assembly namespace: biological_process def: "Any process that modulates the frequency, rate or extent of motile cilium assembly." [GO_REF:0000058, GOC:cilia, GOC:krc, GOC:TermGenie, PMID:25294941] synonym: "regulation of motile primary cilia assembly" RELATED [GOC:TermGenie] synonym: "regulation of motile primary cilia formation" RELATED [GOC:TermGenie] synonym: "regulation of motile primary cilium assembly" RELATED [] synonym: "regulation of motile primary cilium formation" RELATED [GOC:TermGenie] synonym: "regulation of nodal cilium assembly" RELATED [GOC:TermGenie] synonym: "regulation of nodal cilium formation" RELATED [GOC:TermGenie] is_a: GO:1902017 ! regulation of cilium assembly intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0044458 ! regulates motile cilium assembly relationship: RO:0002211 GO:0044458 ! regulates motile cilium assembly property_value: RO:0002161 NCBITaxon:3176 property_value: RO:0002161 NCBITaxon:3378 property_value: RO:0002161 NCBITaxon:3398 property_value: RO:0002161 NCBITaxon:4751 property_value: RO:0002161 NCBITaxon:5782 creation_date: 2016-09-27T18:27:47Z [Term] id: GO:1905504 name: negative regulation of motile cilium assembly namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of motile cilium assembly." [GO_REF:0000058, GOC:cilia, GOC:krc, GOC:TermGenie, PMID:25294941] synonym: "down regulation of motile primary cilia assembly" RELATED [GOC:TermGenie] synonym: "down regulation of motile primary cilia formation" RELATED [GOC:TermGenie] synonym: "down regulation of motile primary cilium assembly" RELATED [GOC:TermGenie] synonym: "down regulation of motile primary cilium formation" RELATED [GOC:TermGenie] synonym: "down regulation of nodal cilium assembly" RELATED [GOC:TermGenie] synonym: "down regulation of nodal cilium formation" RELATED [GOC:TermGenie] synonym: "down-regulation of motile primary cilia assembly" RELATED [GOC:TermGenie] synonym: "down-regulation of motile primary cilia formation" RELATED [GOC:TermGenie] synonym: "down-regulation of motile primary cilium assembly" RELATED [GOC:TermGenie] synonym: "down-regulation of motile primary cilium formation" RELATED [GOC:TermGenie] synonym: "down-regulation of nodal cilium assembly" RELATED [GOC:TermGenie] synonym: "down-regulation of nodal cilium formation" RELATED [GOC:TermGenie] synonym: "downregulation of motile primary cilia assembly" RELATED [GOC:TermGenie] synonym: "downregulation of motile primary cilia formation" RELATED [GOC:TermGenie] synonym: "downregulation of motile primary cilium assembly" RELATED [GOC:TermGenie] synonym: "downregulation of motile primary cilium formation" RELATED [GOC:TermGenie] synonym: "downregulation of nodal cilium assembly" RELATED [GOC:TermGenie] synonym: "downregulation of nodal cilium formation" RELATED [GOC:TermGenie] synonym: "inhibition of motile primary cilia assembly" NARROW [GOC:TermGenie] synonym: "inhibition of motile primary cilia formation" NARROW [GOC:TermGenie] synonym: "inhibition of motile primary cilium assembly" NARROW [GOC:TermGenie] synonym: "inhibition of motile primary cilium formation" NARROW [GOC:TermGenie] synonym: "inhibition of nodal cilium assembly" RELATED [GOC:TermGenie] synonym: "inhibition of nodal cilium formation" RELATED [GOC:TermGenie] synonym: "negative regulation of motile primary cilia assembly" RELATED [GOC:TermGenie] synonym: "negative regulation of motile primary cilia formation" RELATED [GOC:TermGenie] synonym: "negative regulation of motile primary cilium assembly" RELATED [] synonym: "negative regulation of motile primary cilium formation" RELATED [GOC:TermGenie] synonym: "negative regulation of nodal cilium assembly" RELATED [GOC:TermGenie] synonym: "negative regulation of nodal cilium formation" RELATED [GOC:TermGenie] is_a: GO:1902018 ! negative regulation of cilium assembly is_a: GO:1905503 ! regulation of motile cilium assembly intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0044458 ! negatively regulates motile cilium assembly relationship: RO:0002212 GO:0044458 ! negatively regulates motile cilium assembly property_value: RO:0002161 NCBITaxon:3176 property_value: RO:0002161 NCBITaxon:3378 property_value: RO:0002161 NCBITaxon:3398 property_value: RO:0002161 NCBITaxon:4751 property_value: RO:0002161 NCBITaxon:5782 creation_date: 2016-09-27T18:27:55Z [Term] id: GO:1905505 name: positive regulation of motile cilium assembly namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of motile cilium assembly." [GO_REF:0000058, GOC:cilia, GOC:krc, GOC:TermGenie, PMID:25294941] synonym: "activation of motile primary cilia assembly" NARROW [GOC:TermGenie] synonym: "activation of motile primary cilia formation" NARROW [GOC:TermGenie] synonym: "activation of motile primary cilium assembly" NARROW [GOC:TermGenie] synonym: "activation of motile primary cilium formation" NARROW [GOC:TermGenie] synonym: "activation of nodal cilium assembly" RELATED [GOC:TermGenie] synonym: "activation of nodal cilium formation" RELATED [GOC:TermGenie] synonym: "positive regulation of motile primary cilia assembly" RELATED [GOC:TermGenie] synonym: "positive regulation of motile primary cilia formation" RELATED [GOC:TermGenie] synonym: "positive regulation of motile primary cilium assembly" RELATED [] synonym: "positive regulation of motile primary cilium formation" RELATED [GOC:TermGenie] synonym: "positive regulation of nodal cilium assembly" RELATED [GOC:TermGenie] synonym: "positive regulation of nodal cilium formation" RELATED [GOC:TermGenie] synonym: "up regulation of motile primary cilia assembly" RELATED [GOC:TermGenie] synonym: "up regulation of motile primary cilia formation" RELATED [GOC:TermGenie] synonym: "up regulation of motile primary cilium assembly" RELATED [GOC:TermGenie] synonym: "up regulation of motile primary cilium formation" RELATED [GOC:TermGenie] synonym: "up regulation of nodal cilium assembly" RELATED [GOC:TermGenie] synonym: "up regulation of nodal cilium formation" RELATED [GOC:TermGenie] synonym: "up-regulation of motile primary cilia assembly" RELATED [GOC:TermGenie] synonym: "up-regulation of motile primary cilia formation" RELATED [GOC:TermGenie] synonym: "up-regulation of motile primary cilium assembly" RELATED [GOC:TermGenie] synonym: "up-regulation of motile primary cilium formation" RELATED [GOC:TermGenie] synonym: "up-regulation of nodal cilium assembly" RELATED [GOC:TermGenie] synonym: "up-regulation of nodal cilium formation" RELATED [GOC:TermGenie] synonym: "upregulation of motile primary cilia assembly" RELATED [GOC:TermGenie] synonym: "upregulation of motile primary cilia formation" RELATED [GOC:TermGenie] synonym: "upregulation of motile primary cilium assembly" RELATED [GOC:TermGenie] synonym: "upregulation of motile primary cilium formation" RELATED [GOC:TermGenie] synonym: "upregulation of nodal cilium assembly" RELATED [GOC:TermGenie] synonym: "upregulation of nodal cilium formation" RELATED [GOC:TermGenie] is_a: GO:0045724 ! positive regulation of cilium assembly is_a: GO:1905503 ! regulation of motile cilium assembly intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0044458 ! positively regulates motile cilium assembly relationship: RO:0002213 GO:0044458 ! positively regulates motile cilium assembly property_value: RO:0002161 NCBITaxon:3176 property_value: RO:0002161 NCBITaxon:3378 property_value: RO:0002161 NCBITaxon:3398 property_value: RO:0002161 NCBITaxon:4751 property_value: RO:0002161 NCBITaxon:5782 creation_date: 2016-09-27T18:28:03Z [Term] id: GO:1905508 name: protein localization to microtubule organizing center namespace: biological_process def: "A process in which a protein is transported to, or maintained in, a location within a microtubule organizing center." [GO_REF:0000087, GOC:TermGenie, PMID:19001497] synonym: "protein localisation in microtubule organizing center" EXACT [GOC:TermGenie] synonym: "protein localisation to microtubule organizing center" EXACT [GOC:TermGenie] synonym: "protein localization in microtubule organizing center" EXACT [GOC:TermGenie] is_a: GO:0072698 ! protein localization to microtubule cytoskeleton intersection_of: GO:0008104 ! intracellular protein localization intersection_of: RO:0002339 GO:0005815 ! has target end location microtubule organizing center relationship: RO:0002339 GO:0005815 ! has target end location microtubule organizing center creation_date: 2016-09-28T12:32:16Z [Term] id: GO:1905515 name: non-motile cilium assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form a non-motile cilium." [GO_REF:0000079, GOC:cilia, GOC:kmv, GOC:TermGenie, PMID:14521833, PMID:14521834] synonym: "immotile primary cilium assembly" RELATED [GOC:bf] synonym: "non-motile cilium formation" EXACT [GOC:TermGenie] synonym: "nonmotile cilium assembly" EXACT [GOC:TermGenie] synonym: "nonmotile cilium formation" EXACT [GOC:TermGenie] synonym: "nonmotile primary cilia assembly" RELATED [GOC:bf] synonym: "nonmotile primary cilium assembly" RELATED [] synonym: "sensory cilium assembly" RELATED [GOC:kmv] synonym: "sensory cilium biogenesis" RELATED [GOC:mah] is_a: GO:0060271 ! cilium assembly intersection_of: GO:0022607 ! cellular component assembly intersection_of: RO:0002588 GO:0097730 ! results in assembly of non-motile cilium relationship: RO:0002588 GO:0097730 ! results in assembly of non-motile cilium property_value: RO:0002161 NCBITaxon:3176 property_value: RO:0002161 NCBITaxon:3378 property_value: RO:0002161 NCBITaxon:3398 property_value: RO:0002161 NCBITaxon:4890 property_value: RO:0002161 NCBITaxon:5782 creation_date: 2016-09-30T11:55:15Z [Term] id: GO:1905516 name: positive regulation of fertilization namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of fertilization." [GO_REF:0000058, GOC:hbye, GOC:TermGenie, PMID:27564576] synonym: "activation of fertilization" NARROW [GOC:TermGenie] synonym: "activation of syngamy" NARROW [GOC:TermGenie] synonym: "positive regulation of syngamy" EXACT [GOC:TermGenie] synonym: "up regulation of fertilization" EXACT [GOC:TermGenie] synonym: "up regulation of syngamy" EXACT [GOC:TermGenie] synonym: "up-regulation of fertilization" EXACT [GOC:TermGenie] synonym: "up-regulation of syngamy" EXACT [GOC:TermGenie] synonym: "upregulation of fertilization" EXACT [GOC:TermGenie] synonym: "upregulation of syngamy" EXACT [GOC:TermGenie] is_a: GO:0080154 ! regulation of fertilization is_a: GO:2000243 ! positive regulation of reproductive process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0009566 ! positively regulates fertilization relationship: RO:0002213 GO:0009566 ! positively regulates fertilization creation_date: 2016-09-30T14:32:32Z [Term] id: GO:1905517 name: macrophage migration namespace: biological_process def: "The orderly movement of a macrophage from one site to another." [GO_REF:0000091, GOC:TermGenie, PMID:25749876] is_a: GO:0071674 ! mononuclear cell migration is_a: GO:0097529 ! myeloid leukocyte migration intersection_of: GO:0016477 ! cell migration intersection_of: RO:0002565 CL:0000235 ! results in movement of macrophage relationship: RO:0002565 CL:0000235 ! results in movement of macrophage creation_date: 2016-09-30T22:17:45Z [Term] id: GO:1905521 name: regulation of macrophage migration namespace: biological_process def: "Any process that modulates the frequency, rate or extent of macrophage migration." [GO_REF:0000058, GOC:TermGenie, PMID:25749876] is_a: GO:0071675 ! regulation of mononuclear cell migration intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:1905517 ! regulates macrophage migration relationship: RO:0002211 GO:1905517 ! regulates macrophage migration creation_date: 2016-10-03T15:29:06Z [Term] id: GO:1905522 name: negative regulation of macrophage migration namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of macrophage migration." [GO_REF:0000058, GOC:TermGenie, PMID:25749876] synonym: "down regulation of macrophage migration" EXACT [GOC:TermGenie] synonym: "down-regulation of macrophage migration" EXACT [GOC:TermGenie] synonym: "downregulation of macrophage migration" EXACT [GOC:TermGenie] synonym: "inhibition of macrophage migration" NARROW [GOC:TermGenie] is_a: GO:0071676 ! negative regulation of mononuclear cell migration is_a: GO:1905521 ! regulation of macrophage migration intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:1905517 ! negatively regulates macrophage migration relationship: RO:0002212 GO:1905517 ! negatively regulates macrophage migration creation_date: 2016-10-03T15:29:14Z [Term] id: GO:1905523 name: positive regulation of macrophage migration namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of macrophage migration." [GO_REF:0000058, GOC:TermGenie, PMID:25749876] synonym: "activation of macrophage migration" NARROW [GOC:TermGenie] synonym: "up regulation of macrophage migration" EXACT [GOC:TermGenie] synonym: "up-regulation of macrophage migration" EXACT [GOC:TermGenie] synonym: "upregulation of macrophage migration" EXACT [GOC:TermGenie] is_a: GO:0071677 ! positive regulation of mononuclear cell migration is_a: GO:1905521 ! regulation of macrophage migration intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:1905517 ! positively regulates macrophage migration relationship: RO:0002213 GO:1905517 ! positively regulates macrophage migration creation_date: 2016-10-03T15:29:21Z [Term] id: GO:1905553 name: regulation of blood vessel branching namespace: biological_process def: "Any process that modulates the frequency, rate or extent of blood vessel branching." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:23201774] synonym: "regulation of branching involved in blood vessel morphogenesis" EXACT [GOC:TermGenie] is_a: GO:0045765 ! regulation of angiogenesis is_a: GO:0060688 ! regulation of morphogenesis of a branching structure is_a: GO:1905330 ! regulation of morphogenesis of an epithelium intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0001569 ! regulates branching involved in blood vessel morphogenesis relationship: RO:0002211 GO:0001569 ! regulates branching involved in blood vessel morphogenesis creation_date: 2016-10-12T14:19:33Z [Term] id: GO:1905554 name: negative regulation of blood vessel branching namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of blood vessel branching." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:23201774] synonym: "down regulation of branching involved in blood vessel morphogenesis" EXACT [GOC:TermGenie] synonym: "down regulation of patterning of blood vessels" EXACT [GOC:TermGenie] synonym: "down-regulation of branching involved in blood vessel morphogenesis" EXACT [GOC:TermGenie] synonym: "down-regulation of patterning of blood vessels" EXACT [GOC:TermGenie] synonym: "downregulation of branching involved in blood vessel morphogenesis" EXACT [GOC:TermGenie] synonym: "downregulation of patterning of blood vessels" EXACT [GOC:TermGenie] synonym: "inhibition of branching involved in blood vessel morphogenesis" NARROW [GOC:TermGenie] synonym: "inhibition of patterning of blood vessels" NARROW [GOC:TermGenie] synonym: "negative regulation of branching involved in blood vessel morphogenesis" EXACT [GOC:TermGenie] is_a: GO:0016525 ! negative regulation of angiogenesis is_a: GO:1905331 ! negative regulation of morphogenesis of an epithelium is_a: GO:1905553 ! regulation of blood vessel branching intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0001569 ! negatively regulates branching involved in blood vessel morphogenesis relationship: RO:0002212 GO:0001569 ! negatively regulates branching involved in blood vessel morphogenesis property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/29454" xsd:anyURI creation_date: 2016-10-12T14:19:41Z [Term] id: GO:1905555 name: positive regulation of blood vessel branching namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of blood vessel branching." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:23201774] synonym: "activation of branching involved in blood vessel morphogenesis" NARROW [GOC:TermGenie] synonym: "activation of patterning of blood vessels" NARROW [GOC:TermGenie] synonym: "positive regulation of branching involved in blood vessel morphogenesis" EXACT [GOC:TermGenie] synonym: "up regulation of branching involved in blood vessel morphogenesis" EXACT [GOC:TermGenie] synonym: "up regulation of patterning of blood vessels" EXACT [GOC:TermGenie] synonym: "up-regulation of branching involved in blood vessel morphogenesis" EXACT [GOC:TermGenie] synonym: "up-regulation of patterning of blood vessels" EXACT [GOC:TermGenie] synonym: "upregulation of branching involved in blood vessel morphogenesis" EXACT [GOC:TermGenie] synonym: "upregulation of patterning of blood vessels" EXACT [GOC:TermGenie] is_a: GO:0045766 ! positive regulation of angiogenesis is_a: GO:1905332 ! positive regulation of morphogenesis of an epithelium is_a: GO:1905553 ! regulation of blood vessel branching intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0001569 ! positively regulates branching involved in blood vessel morphogenesis relationship: RO:0002213 GO:0001569 ! positively regulates branching involved in blood vessel morphogenesis creation_date: 2016-10-12T14:19:49Z [Term] id: GO:1905557 name: regulation of mitotic nuclear envelope disassembly namespace: biological_process def: "Any process that modulates the frequency, rate or extent of mitotic nuclear envelope disassembly." [GO_REF:0000058, GOC:TermGenie, PMID:18765790] synonym: "regulation of mitotic nuclear envelope breakdown" EXACT [GOC:TermGenie] synonym: "regulation of mitotic nuclear envelope catabolism" EXACT [GOC:TermGenie] synonym: "regulation of mitotic nuclear envelope degradation" EXACT [GOC:TermGenie] is_a: GO:0010549 ! regulation of membrane disassembly is_a: GO:0010564 ! regulation of cell cycle process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0007077 ! regulates mitotic nuclear membrane disassembly relationship: RO:0002211 GO:0007077 ! regulates mitotic nuclear membrane disassembly creation_date: 2016-10-14T13:14:57Z [Term] id: GO:1905558 name: negative regulation of mitotic nuclear envelope disassembly namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of mitotic nuclear envelope disassembly." [GO_REF:0000058, GOC:TermGenie, PMID:18765790] synonym: "down regulation of mitotic nuclear envelope breakdown" EXACT [GOC:TermGenie] synonym: "down regulation of mitotic nuclear envelope catabolism" EXACT [GOC:TermGenie] synonym: "down regulation of mitotic nuclear envelope degradation" EXACT [GOC:TermGenie] synonym: "down regulation of mitotic nuclear envelope disassembly" EXACT [GOC:TermGenie] synonym: "down-regulation of mitotic nuclear envelope breakdown" EXACT [GOC:TermGenie] synonym: "down-regulation of mitotic nuclear envelope catabolism" EXACT [GOC:TermGenie] synonym: "down-regulation of mitotic nuclear envelope degradation" EXACT [GOC:TermGenie] synonym: "down-regulation of mitotic nuclear envelope disassembly" EXACT [GOC:TermGenie] synonym: "downregulation of mitotic nuclear envelope breakdown" EXACT [GOC:TermGenie] synonym: "downregulation of mitotic nuclear envelope catabolism" EXACT [GOC:TermGenie] synonym: "downregulation of mitotic nuclear envelope degradation" EXACT [GOC:TermGenie] synonym: "downregulation of mitotic nuclear envelope disassembly" EXACT [GOC:TermGenie] synonym: "inhibition of mitotic nuclear envelope breakdown" NARROW [GOC:TermGenie] synonym: "inhibition of mitotic nuclear envelope catabolism" NARROW [GOC:TermGenie] synonym: "inhibition of mitotic nuclear envelope degradation" NARROW [GOC:TermGenie] synonym: "inhibition of mitotic nuclear envelope disassembly" NARROW [GOC:TermGenie] synonym: "negative regulation of mitotic nuclear envelope breakdown" EXACT [GOC:TermGenie] synonym: "negative regulation of mitotic nuclear envelope catabolism" EXACT [GOC:TermGenie] synonym: "negative regulation of mitotic nuclear envelope degradation" EXACT [GOC:TermGenie] is_a: GO:0010948 ! negative regulation of cell cycle process is_a: GO:0051129 ! negative regulation of cellular component organization is_a: GO:1905557 ! regulation of mitotic nuclear envelope disassembly intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0007077 ! negatively regulates mitotic nuclear membrane disassembly relationship: RO:0002212 GO:0007077 ! negatively regulates mitotic nuclear membrane disassembly creation_date: 2016-10-14T13:15:08Z [Term] id: GO:1905559 name: positive regulation of mitotic nuclear envelope disassembly namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of mitotic nuclear envelope disassembly." [GO_REF:0000058, GOC:TermGenie, PMID:18765790] synonym: "activation of mitotic nuclear envelope breakdown" NARROW [GOC:TermGenie] synonym: "activation of mitotic nuclear envelope catabolism" NARROW [GOC:TermGenie] synonym: "activation of mitotic nuclear envelope degradation" NARROW [GOC:TermGenie] synonym: "activation of mitotic nuclear envelope disassembly" NARROW [GOC:TermGenie] synonym: "positive regulation of mitotic nuclear envelope breakdown" EXACT [GOC:TermGenie] synonym: "positive regulation of mitotic nuclear envelope catabolism" EXACT [GOC:TermGenie] synonym: "positive regulation of mitotic nuclear envelope degradation" EXACT [GOC:TermGenie] synonym: "up regulation of mitotic nuclear envelope breakdown" EXACT [GOC:TermGenie] synonym: "up regulation of mitotic nuclear envelope catabolism" EXACT [GOC:TermGenie] synonym: "up regulation of mitotic nuclear envelope degradation" EXACT [GOC:TermGenie] synonym: "up regulation of mitotic nuclear envelope disassembly" EXACT [GOC:TermGenie] synonym: "up-regulation of mitotic nuclear envelope breakdown" EXACT [GOC:TermGenie] synonym: "up-regulation of mitotic nuclear envelope catabolism" EXACT [GOC:TermGenie] synonym: "up-regulation of mitotic nuclear envelope degradation" EXACT [GOC:TermGenie] synonym: "up-regulation of mitotic nuclear envelope disassembly" EXACT [GOC:TermGenie] synonym: "upregulation of mitotic nuclear envelope breakdown" EXACT [GOC:TermGenie] synonym: "upregulation of mitotic nuclear envelope catabolism" EXACT [GOC:TermGenie] synonym: "upregulation of mitotic nuclear envelope degradation" EXACT [GOC:TermGenie] synonym: "upregulation of mitotic nuclear envelope disassembly" EXACT [GOC:TermGenie] is_a: GO:0051130 ! positive regulation of cellular component organization is_a: GO:0090068 ! positive regulation of cell cycle process is_a: GO:1905557 ! regulation of mitotic nuclear envelope disassembly intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0007077 ! positively regulates mitotic nuclear membrane disassembly relationship: RO:0002213 GO:0007077 ! positively regulates mitotic nuclear membrane disassembly creation_date: 2016-10-14T13:15:17Z [Term] id: GO:1905562 name: regulation of vascular endothelial cell proliferation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of vascular endothelial cell proliferation." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:23201774] is_a: GO:0001936 ! regulation of endothelial cell proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0101023 ! regulates vascular endothelial cell proliferation relationship: RO:0002211 GO:0101023 ! regulates vascular endothelial cell proliferation property_value: RO:0002161 NCBITaxon:4751 creation_date: 2016-10-17T09:24:17Z [Term] id: GO:1905563 name: negative regulation of vascular endothelial cell proliferation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of vascular endothelial cell proliferation." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:23201774] synonym: "down regulation of vascular endothelial cell proliferation" EXACT [GOC:TermGenie] synonym: "down-regulation of vascular endothelial cell proliferation" EXACT [GOC:TermGenie] synonym: "downregulation of vascular endothelial cell proliferation" EXACT [GOC:TermGenie] synonym: "inhibition of vascular endothelial cell proliferation" NARROW [GOC:TermGenie] is_a: GO:0001937 ! negative regulation of endothelial cell proliferation is_a: GO:1905562 ! regulation of vascular endothelial cell proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0101023 ! negatively regulates vascular endothelial cell proliferation relationship: RO:0002212 GO:0101023 ! negatively regulates vascular endothelial cell proliferation property_value: RO:0002161 NCBITaxon:4751 creation_date: 2016-10-17T09:24:26Z [Term] id: GO:1905564 name: positive regulation of vascular endothelial cell proliferation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of vascular endothelial cell proliferation." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:23201774] synonym: "activation of vascular endothelial cell proliferation" NARROW [GOC:TermGenie] synonym: "up regulation of vascular endothelial cell proliferation" EXACT [GOC:TermGenie] synonym: "up-regulation of vascular endothelial cell proliferation" EXACT [GOC:TermGenie] synonym: "upregulation of vascular endothelial cell proliferation" EXACT [GOC:TermGenie] is_a: GO:0001938 ! positive regulation of endothelial cell proliferation is_a: GO:1905562 ! regulation of vascular endothelial cell proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0101023 ! positively regulates vascular endothelial cell proliferation relationship: RO:0002213 GO:0101023 ! positively regulates vascular endothelial cell proliferation property_value: RO:0002161 NCBITaxon:4751 creation_date: 2016-10-17T09:24:35Z [Term] id: GO:1905584 name: outer hair cell apoptotic process namespace: biological_process def: "Any apoptotic process in an outer hair cell." [GO_REF:0000085, GOC:TermGenie, PMID:12062759, PMID:24472721] synonym: "cochlear outer hair cell apoptosis" NARROW [GOC:TermGenie] synonym: "cochlear outer hair cell apoptotic process" EXACT [GOC:TermGenie] synonym: "outer hair cell apoptosis" NARROW [GOC:TermGenie] is_a: GO:0051402 ! neuron apoptotic process intersection_of: GO:0006915 ! apoptotic process intersection_of: BFO:0000066 CL:0000601 ! occurs in cochlear outer hair cell relationship: BFO:0000066 CL:0000601 ! occurs in cochlear outer hair cell property_value: RO:0002161 NCBITaxon:4896 creation_date: 2016-10-21T22:42:13Z [Term] id: GO:1905585 name: regulation of outer hair cell apoptotic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of outer hair cell apoptotic process." [GO_REF:0000058, GOC:TermGenie, PMID:24472721] synonym: "regulation of cochlear outer hair cell apoptosis" NARROW [GOC:TermGenie] synonym: "regulation of cochlear outer hair cell apoptotic process" EXACT [GOC:TermGenie] synonym: "regulation of outer hair cell apoptosis" NARROW [GOC:TermGenie] is_a: GO:0043523 ! regulation of neuron apoptotic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:1905584 ! regulates outer hair cell apoptotic process relationship: RO:0002211 GO:1905584 ! regulates outer hair cell apoptotic process property_value: RO:0002161 NCBITaxon:4896 creation_date: 2016-10-24T22:35:34Z [Term] id: GO:1905586 name: negative regulation of outer hair cell apoptotic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of outer hair cell apoptotic process." [GO_REF:0000058, GOC:TermGenie, PMID:24472721] synonym: "down regulation of cochlear outer hair cell apoptosis" NARROW [GOC:TermGenie] synonym: "down regulation of cochlear outer hair cell apoptotic process" EXACT [GOC:TermGenie] synonym: "down regulation of outer hair cell apoptosis" NARROW [GOC:TermGenie] synonym: "down regulation of outer hair cell apoptotic process" EXACT [GOC:TermGenie] synonym: "down-regulation of cochlear outer hair cell apoptosis" NARROW [GOC:TermGenie] synonym: "down-regulation of cochlear outer hair cell apoptotic process" EXACT [GOC:TermGenie] synonym: "down-regulation of outer hair cell apoptosis" NARROW [GOC:TermGenie] synonym: "down-regulation of outer hair cell apoptotic process" EXACT [GOC:TermGenie] synonym: "downregulation of cochlear outer hair cell apoptosis" NARROW [GOC:TermGenie] synonym: "downregulation of cochlear outer hair cell apoptotic process" EXACT [GOC:TermGenie] synonym: "downregulation of outer hair cell apoptosis" NARROW [GOC:TermGenie] synonym: "downregulation of outer hair cell apoptotic process" EXACT [GOC:TermGenie] synonym: "inhibition of cochlear outer hair cell apoptosis" NARROW [GOC:TermGenie] synonym: "inhibition of cochlear outer hair cell apoptotic process" NARROW [GOC:TermGenie] synonym: "inhibition of outer hair cell apoptosis" NARROW [GOC:TermGenie] synonym: "inhibition of outer hair cell apoptotic process" NARROW [GOC:TermGenie] synonym: "negative regulation of cochlear outer hair cell apoptosis" NARROW [GOC:TermGenie] synonym: "negative regulation of cochlear outer hair cell apoptotic process" EXACT [GOC:TermGenie] synonym: "negative regulation of outer hair cell apoptosis" NARROW [GOC:TermGenie] is_a: GO:0043524 ! negative regulation of neuron apoptotic process is_a: GO:1905585 ! regulation of outer hair cell apoptotic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:1905584 ! negatively regulates outer hair cell apoptotic process relationship: RO:0002212 GO:1905584 ! negatively regulates outer hair cell apoptotic process property_value: RO:0002161 NCBITaxon:4896 creation_date: 2016-10-24T22:35:43Z [Term] id: GO:1905587 name: positive regulation of outer hair cell apoptotic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of outer hair cell apoptotic process." [GO_REF:0000058, GOC:TermGenie, PMID:24472721] synonym: "activation of cochlear outer hair cell apoptosis" NARROW [GOC:TermGenie] synonym: "activation of cochlear outer hair cell apoptotic process" NARROW [GOC:TermGenie] synonym: "activation of outer hair cell apoptosis" NARROW [GOC:TermGenie] synonym: "activation of outer hair cell apoptotic process" NARROW [GOC:TermGenie] synonym: "positive regulation of cochlear outer hair cell apoptosis" NARROW [GOC:TermGenie] synonym: "positive regulation of cochlear outer hair cell apoptotic process" EXACT [GOC:TermGenie] synonym: "positive regulation of outer hair cell apoptosis" NARROW [GOC:TermGenie] synonym: "up regulation of cochlear outer hair cell apoptosis" NARROW [GOC:TermGenie] synonym: "up regulation of cochlear outer hair cell apoptotic process" EXACT [GOC:TermGenie] synonym: "up regulation of outer hair cell apoptosis" NARROW [GOC:TermGenie] synonym: "up regulation of outer hair cell apoptotic process" EXACT [GOC:TermGenie] synonym: "up-regulation of cochlear outer hair cell apoptosis" NARROW [GOC:TermGenie] synonym: "up-regulation of cochlear outer hair cell apoptotic process" EXACT [GOC:TermGenie] synonym: "up-regulation of outer hair cell apoptosis" NARROW [GOC:TermGenie] synonym: "up-regulation of outer hair cell apoptotic process" EXACT [GOC:TermGenie] synonym: "upregulation of cochlear outer hair cell apoptosis" NARROW [GOC:TermGenie] synonym: "upregulation of cochlear outer hair cell apoptotic process" EXACT [GOC:TermGenie] synonym: "upregulation of outer hair cell apoptosis" NARROW [GOC:TermGenie] synonym: "upregulation of outer hair cell apoptotic process" EXACT [GOC:TermGenie] is_a: GO:0043525 ! positive regulation of neuron apoptotic process is_a: GO:1905585 ! regulation of outer hair cell apoptotic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:1905584 ! positively regulates outer hair cell apoptotic process relationship: RO:0002213 GO:1905584 ! positively regulates outer hair cell apoptotic process property_value: RO:0002161 NCBITaxon:4896 creation_date: 2016-10-24T22:35:51Z [Term] id: GO:1905606 name: regulation of presynapse assembly namespace: biological_process def: "Any process that modulates the frequency, rate or extent of presynapse assembly." [GO_REF:0000058, GOC:bc, GOC:PARL, GOC:TermGenie, PMID:25533483] subset: goslim_synapse synonym: "regulation of presynapse biogenesis" EXACT [GOC:TermGenie] synonym: "regulation of presynaptic terminal assembly" EXACT [GOC:TermGenie] is_a: GO:0051963 ! regulation of synapse assembly is_a: GO:0099174 ! regulation of presynapse organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0099054 ! regulates presynapse assembly relationship: RO:0002211 GO:0099054 ! regulates presynapse assembly creation_date: 2016-10-27T16:08:13Z [Term] id: GO:1905607 name: negative regulation of presynapse assembly namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of presynapse assembly." [GO_REF:0000058, GOC:bc, GOC:PARL, GOC:TermGenie, PMID:25533483] synonym: "down regulation of presynapse assembly" EXACT [GOC:TermGenie] synonym: "down regulation of presynapse biogenesis" EXACT [GOC:TermGenie] synonym: "down regulation of presynaptic terminal assembly" EXACT [GOC:TermGenie] synonym: "down-regulation of presynapse assembly" EXACT [GOC:TermGenie] synonym: "down-regulation of presynapse biogenesis" EXACT [GOC:TermGenie] synonym: "down-regulation of presynaptic terminal assembly" EXACT [GOC:TermGenie] synonym: "downregulation of presynapse assembly" EXACT [GOC:TermGenie] synonym: "downregulation of presynapse biogenesis" EXACT [GOC:TermGenie] synonym: "downregulation of presynaptic terminal assembly" EXACT [GOC:TermGenie] synonym: "inhibition of presynapse assembly" NARROW [GOC:TermGenie] synonym: "inhibition of presynapse biogenesis" NARROW [GOC:TermGenie] synonym: "inhibition of presynaptic terminal assembly" NARROW [GOC:TermGenie] synonym: "negative regulation of presynapse biogenesis" EXACT [GOC:TermGenie] synonym: "negative regulation of presynaptic terminal assembly" EXACT [GOC:TermGenie] is_a: GO:0051964 ! negative regulation of synapse assembly is_a: GO:1905606 ! regulation of presynapse assembly intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0099054 ! negatively regulates presynapse assembly relationship: RO:0002212 GO:0099054 ! negatively regulates presynapse assembly creation_date: 2016-10-27T16:08:20Z [Term] id: GO:1905608 name: positive regulation of presynapse assembly namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of presynapse assembly." [GO_REF:0000058, GOC:bc, GOC:PARL, GOC:TermGenie, PMID:25533483] synonym: "activation of presynapse assembly" NARROW [GOC:TermGenie] synonym: "activation of presynapse biogenesis" NARROW [GOC:TermGenie] synonym: "activation of presynaptic terminal assembly" NARROW [GOC:TermGenie] synonym: "positive regulation of presynapse biogenesis" EXACT [GOC:TermGenie] synonym: "positive regulation of presynaptic terminal assembly" EXACT [GOC:TermGenie] synonym: "up regulation of presynapse assembly" EXACT [GOC:TermGenie] synonym: "up regulation of presynapse biogenesis" EXACT [GOC:TermGenie] synonym: "up regulation of presynaptic terminal assembly" EXACT [GOC:TermGenie] synonym: "up-regulation of presynapse assembly" EXACT [GOC:TermGenie] synonym: "up-regulation of presynapse biogenesis" EXACT [GOC:TermGenie] synonym: "up-regulation of presynaptic terminal assembly" EXACT [GOC:TermGenie] synonym: "upregulation of presynapse assembly" EXACT [GOC:TermGenie] synonym: "upregulation of presynapse biogenesis" EXACT [GOC:TermGenie] synonym: "upregulation of presynaptic terminal assembly" EXACT [GOC:TermGenie] is_a: GO:0051130 ! positive regulation of cellular component organization is_a: GO:1905606 ! regulation of presynapse assembly intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0099054 ! positively regulates presynapse assembly relationship: RO:0002213 GO:0099054 ! positively regulates presynapse assembly creation_date: 2016-10-27T16:08:28Z [Term] id: GO:1905627 name: regulation of serotonin biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of serotonin biosynthetic process." [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:25642596] synonym: "regulation of serotonin anabolism" EXACT [GOC:TermGenie] synonym: "regulation of serotonin biosynthesis" EXACT [GOC:TermGenie] synonym: "regulation of serotonin formation" EXACT [GOC:TermGenie] synonym: "regulation of serotonin synthesis" EXACT [GOC:TermGenie] is_a: GO:0009889 ! regulation of biosynthetic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0042427 ! regulates serotonin biosynthetic process relationship: RO:0002211 GO:0042427 ! regulates serotonin biosynthetic process creation_date: 2016-10-31T14:26:20Z [Term] id: GO:1905628 name: negative regulation of serotonin biosynthetic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of serotonin biosynthetic process." [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:25642596] synonym: "down regulation of serotonin anabolism" EXACT [GOC:TermGenie] synonym: "down regulation of serotonin biosynthesis" EXACT [GOC:TermGenie] synonym: "down regulation of serotonin biosynthetic process" EXACT [GOC:TermGenie] synonym: "down regulation of serotonin formation" EXACT [GOC:TermGenie] synonym: "down regulation of serotonin synthesis" EXACT [GOC:TermGenie] synonym: "down-regulation of serotonin anabolism" EXACT [GOC:TermGenie] synonym: "down-regulation of serotonin biosynthesis" EXACT [GOC:TermGenie] synonym: "down-regulation of serotonin biosynthetic process" EXACT [GOC:TermGenie] synonym: "down-regulation of serotonin formation" EXACT [GOC:TermGenie] synonym: "down-regulation of serotonin synthesis" EXACT [GOC:TermGenie] synonym: "downregulation of serotonin anabolism" EXACT [GOC:TermGenie] synonym: "downregulation of serotonin biosynthesis" EXACT [GOC:TermGenie] synonym: "downregulation of serotonin biosynthetic process" EXACT [GOC:TermGenie] synonym: "downregulation of serotonin formation" EXACT [GOC:TermGenie] synonym: "downregulation of serotonin synthesis" EXACT [GOC:TermGenie] synonym: "inhibition of serotonin anabolism" NARROW [GOC:TermGenie] synonym: "inhibition of serotonin biosynthesis" NARROW [GOC:TermGenie] synonym: "inhibition of serotonin biosynthetic process" NARROW [GOC:TermGenie] synonym: "inhibition of serotonin formation" NARROW [GOC:TermGenie] synonym: "inhibition of serotonin synthesis" NARROW [GOC:TermGenie] synonym: "negative regulation of serotonin anabolism" EXACT [GOC:TermGenie] synonym: "negative regulation of serotonin biosynthesis" EXACT [GOC:TermGenie] synonym: "negative regulation of serotonin formation" EXACT [GOC:TermGenie] synonym: "negative regulation of serotonin synthesis" EXACT [GOC:TermGenie] is_a: GO:0009890 ! negative regulation of biosynthetic process is_a: GO:1905627 ! regulation of serotonin biosynthetic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0042427 ! negatively regulates serotonin biosynthetic process relationship: RO:0002212 GO:0042427 ! negatively regulates serotonin biosynthetic process creation_date: 2016-10-31T14:26:28Z [Term] id: GO:1905629 name: positive regulation of serotonin biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of serotonin biosynthetic process." [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:25642596] synonym: "activation of serotonin anabolism" NARROW [GOC:TermGenie] synonym: "activation of serotonin biosynthesis" NARROW [GOC:TermGenie] synonym: "activation of serotonin biosynthetic process" NARROW [GOC:TermGenie] synonym: "activation of serotonin formation" NARROW [GOC:TermGenie] synonym: "activation of serotonin synthesis" NARROW [GOC:TermGenie] synonym: "positive regulation of serotonin anabolism" EXACT [GOC:TermGenie] synonym: "positive regulation of serotonin biosynthesis" EXACT [GOC:TermGenie] synonym: "positive regulation of serotonin formation" EXACT [GOC:TermGenie] synonym: "positive regulation of serotonin synthesis" EXACT [GOC:TermGenie] synonym: "up regulation of serotonin anabolism" EXACT [GOC:TermGenie] synonym: "up regulation of serotonin biosynthesis" EXACT [GOC:TermGenie] synonym: "up regulation of serotonin biosynthetic process" EXACT [GOC:TermGenie] synonym: "up regulation of serotonin formation" EXACT [GOC:TermGenie] synonym: "up regulation of serotonin synthesis" EXACT [GOC:TermGenie] synonym: "up-regulation of serotonin anabolism" EXACT [GOC:TermGenie] synonym: "up-regulation of serotonin biosynthesis" EXACT [GOC:TermGenie] synonym: "up-regulation of serotonin biosynthetic process" EXACT [GOC:TermGenie] synonym: "up-regulation of serotonin formation" EXACT [GOC:TermGenie] synonym: "up-regulation of serotonin synthesis" EXACT [GOC:TermGenie] synonym: "upregulation of serotonin anabolism" EXACT [GOC:TermGenie] synonym: "upregulation of serotonin biosynthesis" EXACT [GOC:TermGenie] synonym: "upregulation of serotonin biosynthetic process" EXACT [GOC:TermGenie] synonym: "upregulation of serotonin formation" EXACT [GOC:TermGenie] synonym: "upregulation of serotonin synthesis" EXACT [GOC:TermGenie] is_a: GO:0009891 ! positive regulation of biosynthetic process is_a: GO:1905627 ! regulation of serotonin biosynthetic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0042427 ! positively regulates serotonin biosynthetic process relationship: RO:0002213 GO:0042427 ! positively regulates serotonin biosynthetic process creation_date: 2016-10-31T14:26:36Z [Term] id: GO:1905632 name: protein localization to euchromatin namespace: biological_process def: "A process in which a protein is transported to, or maintained in, a location within an euchromatin." [GO_REF:0000087, GOC:TermGenie, PMID:20889714] synonym: "protein localisation in euchromatin" EXACT [GOC:TermGenie] synonym: "protein localisation to euchromatin" EXACT [GOC:TermGenie] synonym: "protein localization in euchromatin" EXACT [GOC:TermGenie] is_a: GO:0071168 ! protein localization to chromatin intersection_of: GO:0008104 ! intracellular protein localization intersection_of: RO:0002339 GO:0000791 ! has target end location euchromatin relationship: RO:0002339 GO:0000791 ! has target end location euchromatin creation_date: 2016-11-01T16:16:14Z [Term] id: GO:1905633 name: establishment of protein localization to euchromatin namespace: biological_process def: "The directed movement of a protein to a specific location in an euchromatin." [GO_REF:0000087, GOC:TermGenie, PMID:20889714] synonym: "establishment of protein localisation in euchromatin" EXACT [GOC:TermGenie] synonym: "establishment of protein localisation to euchromatin" EXACT [GOC:TermGenie] synonym: "establishment of protein localization in euchromatin" EXACT [GOC:TermGenie] is_a: GO:0071169 ! establishment of protein localization to chromatin intersection_of: GO:0045184 ! establishment of protein localization intersection_of: RO:0002339 GO:0000791 ! has target end location euchromatin relationship: RO:0002339 GO:0000791 ! has target end location euchromatin creation_date: 2016-11-01T16:16:22Z [Term] id: GO:1905634 name: regulation of protein localization to chromatin namespace: biological_process def: "Any process that modulates the frequency, rate or extent of protein localization to chromatin." [GO_REF:0000058, GOC:TermGenie, PMID:20889714] synonym: "regulation of protein localisation to chromatin" EXACT [GOC:TermGenie] is_a: GO:0032880 ! regulation of protein localization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0071168 ! regulates protein localization to chromatin relationship: RO:0002211 GO:0071168 ! regulates protein localization to chromatin creation_date: 2016-11-01T16:33:52Z [Term] id: GO:1905651 name: regulation of artery morphogenesis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of artery morphogenesis." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:27389411] synonym: "regulation of arterial morphogenesis" EXACT [GOC:TermGenie] synonym: "regulation of arteriogenesis" EXACT [GOC:TermGenie] is_a: GO:0022603 ! regulation of anatomical structure morphogenesis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0048844 ! regulates artery morphogenesis relationship: RO:0002211 GO:0048844 ! regulates artery morphogenesis creation_date: 2016-11-09T12:19:37Z [Term] id: GO:1905652 name: negative regulation of artery morphogenesis namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of artery morphogenesis." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:27389411] synonym: "down regulation of arterial morphogenesis" EXACT [GOC:TermGenie] synonym: "down regulation of arteriogenesis" EXACT [GOC:TermGenie] synonym: "down regulation of artery morphogenesis" EXACT [GOC:TermGenie] synonym: "down-regulation of arterial morphogenesis" EXACT [GOC:TermGenie] synonym: "down-regulation of arteriogenesis" EXACT [GOC:TermGenie] synonym: "down-regulation of artery morphogenesis" EXACT [GOC:TermGenie] synonym: "downregulation of arterial morphogenesis" EXACT [GOC:TermGenie] synonym: "downregulation of arteriogenesis" EXACT [GOC:TermGenie] synonym: "downregulation of artery morphogenesis" EXACT [GOC:TermGenie] synonym: "inhibition of arterial morphogenesis" NARROW [GOC:TermGenie] synonym: "inhibition of arteriogenesis" NARROW [GOC:TermGenie] synonym: "inhibition of artery morphogenesis" NARROW [GOC:TermGenie] synonym: "negative regulation of arterial morphogenesis" EXACT [GOC:TermGenie] synonym: "negative regulation of arteriogenesis" EXACT [GOC:TermGenie] is_a: GO:1905651 ! regulation of artery morphogenesis is_a: GO:2000181 ! negative regulation of blood vessel morphogenesis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0048844 ! negatively regulates artery morphogenesis relationship: RO:0002212 GO:0048844 ! negatively regulates artery morphogenesis creation_date: 2016-11-09T12:19:53Z [Term] id: GO:1905653 name: positive regulation of artery morphogenesis namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of artery morphogenesis." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:27389411] synonym: "activation of arterial morphogenesis" NARROW [GOC:TermGenie] synonym: "activation of arteriogenesis" NARROW [GOC:TermGenie] synonym: "activation of artery morphogenesis" NARROW [GOC:TermGenie] synonym: "positive regulation of arterial morphogenesis" EXACT [GOC:TermGenie] synonym: "positive regulation of arteriogenesis" EXACT [GOC:TermGenie] synonym: "up regulation of arterial morphogenesis" EXACT [GOC:TermGenie] synonym: "up regulation of arteriogenesis" EXACT [GOC:TermGenie] synonym: "up regulation of artery morphogenesis" EXACT [GOC:TermGenie] synonym: "up-regulation of arterial morphogenesis" EXACT [GOC:TermGenie] synonym: "up-regulation of arteriogenesis" EXACT [GOC:TermGenie] synonym: "up-regulation of artery morphogenesis" EXACT [GOC:TermGenie] synonym: "upregulation of arterial morphogenesis" EXACT [GOC:TermGenie] synonym: "upregulation of arteriogenesis" EXACT [GOC:TermGenie] synonym: "upregulation of artery morphogenesis" EXACT [GOC:TermGenie] is_a: GO:0051094 ! positive regulation of developmental process is_a: GO:1905651 ! regulation of artery morphogenesis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0048844 ! positively regulates artery morphogenesis relationship: RO:0002213 GO:0048844 ! positively regulates artery morphogenesis creation_date: 2016-11-09T12:20:01Z [Term] id: GO:1905664 name: regulation of calcium ion import across plasma membrane namespace: biological_process def: "Any process that modulates the frequency, rate or extent of calcium ion import across plasma membrane." [GO_REF:0000058, GOC:bhm, GOC:TermGenie, PMID:17640527] comment: An example of this is PPP3CA in human (Q08209) in 17640527 (inferred from direct assay). is_a: GO:0090279 ! regulation of calcium ion import is_a: GO:1903169 ! regulation of calcium ion transmembrane transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0098703 ! regulates calcium ion import across plasma membrane relationship: RO:0002211 GO:0098703 ! regulates calcium ion import across plasma membrane creation_date: 2016-11-11T09:26:06Z [Term] id: GO:1905665 name: positive regulation of calcium ion import across plasma membrane namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of calcium ion import across plasma membrane." [GO_REF:0000058, GOC:bhm, GOC:TermGenie, PMID:17640527] comment: An example of this is PPP3CA in human (Q08209) in 17640527 (inferred from direct assay). synonym: "activation of calcium ion import across plasma membrane" NARROW [GOC:TermGenie] synonym: "up regulation of calcium ion import across plasma membrane" EXACT [GOC:TermGenie] synonym: "up-regulation of calcium ion import across plasma membrane" EXACT [GOC:TermGenie] synonym: "upregulation of calcium ion import across plasma membrane" EXACT [GOC:TermGenie] is_a: GO:0090280 ! positive regulation of calcium ion import is_a: GO:1904427 ! positive regulation of calcium ion transmembrane transport is_a: GO:1905664 ! regulation of calcium ion import across plasma membrane intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0098703 ! positively regulates calcium ion import across plasma membrane relationship: RO:0002213 GO:0098703 ! positively regulates calcium ion import across plasma membrane creation_date: 2016-11-11T09:26:23Z [Term] id: GO:1905671 name: regulation of lysosome organization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of lysosome organization." [GO_REF:0000058, GOC:TermGenie, PMID:25561470] synonym: "regulation of lysosome organisation" EXACT [GOC:TermGenie] synonym: "regulation of lysosome organization and biogenesis" RELATED [GOC:TermGenie] is_a: GO:0044088 ! regulation of vacuole organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0007040 ! regulates lysosome organization relationship: RO:0002211 GO:0007040 ! regulates lysosome organization property_value: RO:0002161 NCBITaxon:4751 creation_date: 2016-11-11T22:01:04Z [Term] id: GO:1905672 name: negative regulation of lysosome organization namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of lysosome organization." [GO_REF:0000058, GOC:TermGenie, PMID:25561470] synonym: "down regulation of lysosome organisation" EXACT [GOC:TermGenie] synonym: "down regulation of lysosome organization" EXACT [GOC:TermGenie] synonym: "down regulation of lysosome organization and biogenesis" RELATED [GOC:TermGenie] synonym: "down-regulation of lysosome organisation" EXACT [GOC:TermGenie] synonym: "down-regulation of lysosome organization" EXACT [GOC:TermGenie] synonym: "down-regulation of lysosome organization and biogenesis" RELATED [GOC:TermGenie] synonym: "downregulation of lysosome organisation" EXACT [GOC:TermGenie] synonym: "downregulation of lysosome organization" EXACT [GOC:TermGenie] synonym: "downregulation of lysosome organization and biogenesis" RELATED [GOC:TermGenie] synonym: "inhibition of lysosome organisation" NARROW [GOC:TermGenie] synonym: "inhibition of lysosome organization" NARROW [GOC:TermGenie] synonym: "inhibition of lysosome organization and biogenesis" RELATED [GOC:TermGenie] synonym: "negative regulation of lysosome organisation" EXACT [GOC:TermGenie] synonym: "negative regulation of lysosome organization and biogenesis" RELATED [GOC:TermGenie] is_a: GO:0010639 ! negative regulation of organelle organization is_a: GO:1905671 ! regulation of lysosome organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0007040 ! negatively regulates lysosome organization relationship: RO:0002212 GO:0007040 ! negatively regulates lysosome organization property_value: RO:0002161 NCBITaxon:4751 creation_date: 2016-11-11T22:01:12Z [Term] id: GO:1905673 name: positive regulation of lysosome organization namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of lysosome organization." [GO_REF:0000058, GOC:TermGenie, PMID:25561470] synonym: "activation of lysosome organisation" NARROW [GOC:TermGenie] synonym: "activation of lysosome organization" NARROW [GOC:TermGenie] synonym: "activation of lysosome organization and biogenesis" RELATED [GOC:TermGenie] synonym: "positive regulation of lysosome organisation" EXACT [GOC:TermGenie] synonym: "positive regulation of lysosome organization and biogenesis" RELATED [GOC:TermGenie] synonym: "up regulation of lysosome organisation" EXACT [GOC:TermGenie] synonym: "up regulation of lysosome organization" EXACT [GOC:TermGenie] synonym: "up regulation of lysosome organization and biogenesis" RELATED [GOC:TermGenie] synonym: "up-regulation of lysosome organisation" EXACT [GOC:TermGenie] synonym: "up-regulation of lysosome organization" EXACT [GOC:TermGenie] synonym: "up-regulation of lysosome organization and biogenesis" RELATED [GOC:TermGenie] synonym: "upregulation of lysosome organisation" EXACT [GOC:TermGenie] synonym: "upregulation of lysosome organization" EXACT [GOC:TermGenie] synonym: "upregulation of lysosome organization and biogenesis" RELATED [GOC:TermGenie] is_a: GO:0044090 ! positive regulation of vacuole organization is_a: GO:1905671 ! regulation of lysosome organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0007040 ! positively regulates lysosome organization relationship: RO:0002213 GO:0007040 ! positively regulates lysosome organization property_value: RO:0002161 NCBITaxon:4751 creation_date: 2016-11-11T22:01:20Z [Term] id: GO:1905690 name: nucleus disassembly namespace: biological_process def: "The disaggregation of a nucleus into its constituent components." [GO_REF:0000079, GOC:autophagy, GOC:pr, GOC:TermGenie] synonym: "cell nucleus disassembly" EXACT [GOC:TermGenie] is_a: GO:0006997 ! nucleus organization is_a: GO:1903008 ! organelle disassembly intersection_of: GO:0022411 ! cellular component disassembly intersection_of: RO:0002590 GO:0005634 ! results in disassembly of nucleus relationship: RO:0002590 GO:0005634 ! results in disassembly of nucleus creation_date: 2016-11-14T13:38:57Z [Term] id: GO:1905720 name: cytoplasmic microtubule bundle namespace: cellular_component def: "Any microtubule bundle that is part of a cytoplasm." [GO_REF:0000064, GOC:TermGenie, PMID:11007487, PMID:26124291] synonym: "microtubule bundle of cytoplasm" EXACT [GOC:TermGenie] synonym: "microtubule fascicle of cytoplasm" EXACT [GOC:TermGenie] is_a: GO:0097427 ! microtubule bundle intersection_of: GO:0097427 ! microtubule bundle intersection_of: BFO:0000050 GO:0005737 ! part of cytoplasm relationship: BFO:0000050 GO:0005737 ! part of cytoplasm creation_date: 2016-11-24T16:52:02Z [Term] id: GO:1905741 name: calcium export from the mitochondrion involved in positive regulation of presynaptic cytosolic calcium concentration namespace: biological_process def: "Any mitochondrial calcium release that is involved in positive regulation of presynaptic cytosolic calcium concentration." [GO_REF:0000060, GOC:TermGenie, PMID:26644474] synonym: "calcium ion transmembrane export from mitochondrion involved in positive regulation of presynaptic cytosolic calcium concentration" EXACT [GOC:TermGenie] synonym: "mitochondrial calcium release involved in positive regulation of presynaptic cytosolic calcium concentration" EXACT [] is_a: GO:0051649 ! establishment of localization in cell is_a: GO:0099093 ! calcium export from the mitochondrion intersection_of: GO:0099093 ! calcium export from the mitochondrion intersection_of: BFO:0000050 GO:0099533 ! part of positive regulation of presynaptic cytosolic calcium concentration relationship: BFO:0000050 GO:0099533 ! part of positive regulation of presynaptic cytosolic calcium concentration creation_date: 2016-12-06T10:05:01Z [Term] id: GO:1905747 name: negative regulation of saliva secretion namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of saliva secretion." [GO_REF:0000058, GOC:TermGenie, PMID:23419067] synonym: "down regulation of saliva secretion" EXACT [GOC:TermGenie] synonym: "down regulation of salivation" EXACT [GOC:TermGenie] synonym: "down-regulation of saliva secretion" EXACT [GOC:TermGenie] synonym: "down-regulation of salivation" EXACT [GOC:TermGenie] synonym: "downregulation of saliva secretion" EXACT [GOC:TermGenie] synonym: "downregulation of salivation" EXACT [GOC:TermGenie] synonym: "inhibition of saliva secretion" NARROW [GOC:TermGenie] synonym: "inhibition of salivation" NARROW [GOC:TermGenie] synonym: "negative regulation of salivation" EXACT [GOC:TermGenie] is_a: GO:0046877 ! regulation of saliva secretion is_a: GO:0051048 ! negative regulation of secretion is_a: GO:0060457 ! negative regulation of digestive system process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0046541 ! negatively regulates saliva secretion relationship: RO:0002212 GO:0046541 ! negatively regulates saliva secretion property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 creation_date: 2016-12-09T10:24:00Z [Term] id: GO:1905755 name: protein localization to cytoplasmic microtubule namespace: biological_process def: "A process in which a protein is transported to, or maintained in, a location within a cytoplasmic microtubule." [GO_REF:0000087, GOC:TermGenie, PMID:15177031] synonym: "protein localisation to cytoplasmic microtubule" EXACT [GOC:TermGenie] is_a: GO:0035372 ! protein localization to microtubule intersection_of: GO:0008104 ! intracellular protein localization intersection_of: RO:0002339 GO:0005881 ! has target end location cytoplasmic microtubule relationship: RO:0002339 GO:0005881 ! has target end location cytoplasmic microtubule creation_date: 2016-12-12T15:31:07Z [Term] id: GO:1905770 name: regulation of mesodermal cell differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of mesodermal cell differentiation." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:23765923] synonym: "regulation of mesoderm cell differentiation" EXACT [GOC:TermGenie] is_a: GO:0045595 ! regulation of cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0048333 ! regulates mesodermal cell differentiation relationship: RO:0002211 GO:0048333 ! regulates mesodermal cell differentiation creation_date: 2016-12-21T12:44:13Z [Term] id: GO:1905771 name: negative regulation of mesodermal cell differentiation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of mesodermal cell differentiation." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:23765923] synonym: "down regulation of mesoderm cell differentiation" EXACT [GOC:TermGenie] synonym: "down regulation of mesodermal cell differentiation" EXACT [GOC:TermGenie] synonym: "down-regulation of mesoderm cell differentiation" EXACT [GOC:TermGenie] synonym: "down-regulation of mesodermal cell differentiation" EXACT [GOC:TermGenie] synonym: "downregulation of mesoderm cell differentiation" EXACT [GOC:TermGenie] synonym: "downregulation of mesodermal cell differentiation" EXACT [GOC:TermGenie] synonym: "inhibition of mesoderm cell differentiation" NARROW [GOC:TermGenie] synonym: "inhibition of mesodermal cell differentiation" NARROW [GOC:TermGenie] synonym: "negative regulation of mesoderm cell differentiation" EXACT [GOC:TermGenie] is_a: GO:0045596 ! negative regulation of cell differentiation is_a: GO:1905770 ! regulation of mesodermal cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0048333 ! negatively regulates mesodermal cell differentiation relationship: RO:0002212 GO:0048333 ! negatively regulates mesodermal cell differentiation creation_date: 2016-12-21T12:44:23Z [Term] id: GO:1905772 name: positive regulation of mesodermal cell differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of mesodermal cell differentiation." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:23765923] synonym: "activation of mesoderm cell differentiation" NARROW [GOC:TermGenie] synonym: "activation of mesodermal cell differentiation" NARROW [GOC:TermGenie] synonym: "positive regulation of mesoderm cell differentiation" EXACT [GOC:TermGenie] synonym: "up regulation of mesoderm cell differentiation" EXACT [GOC:TermGenie] synonym: "up regulation of mesodermal cell differentiation" EXACT [GOC:TermGenie] synonym: "up-regulation of mesoderm cell differentiation" EXACT [GOC:TermGenie] synonym: "up-regulation of mesodermal cell differentiation" EXACT [GOC:TermGenie] synonym: "upregulation of mesoderm cell differentiation" EXACT [GOC:TermGenie] synonym: "upregulation of mesodermal cell differentiation" EXACT [GOC:TermGenie] is_a: GO:0045597 ! positive regulation of cell differentiation is_a: GO:1905770 ! regulation of mesodermal cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0048333 ! positively regulates mesodermal cell differentiation relationship: RO:0002213 GO:0048333 ! positively regulates mesodermal cell differentiation creation_date: 2016-12-21T12:44:32Z [Term] id: GO:1905787 name: regulation of detection of mechanical stimulus involved in sensory perception of touch namespace: biological_process def: "Any process that modulates the frequency, rate or extent of detection of mechanical stimulus involved in sensory perception of touch." [GO_REF:0000058, GOC:TermGenie, PMID:8692859] synonym: "regulation of perception of touch, detection of mechanical stimulus" EXACT [GOC:TermGenie] synonym: "regulation of perception of touch, sensory detection of mechanical stimulus" EXACT [GOC:TermGenie] synonym: "regulation of perception of touch, sensory transduction of mechanical stimulus" EXACT [GOC:TermGenie] synonym: "regulation of sensory detection of mechanical stimulus during perception of touch" EXACT [GOC:TermGenie] synonym: "regulation of sensory transduction of mechanical stimulus during perception of touch" EXACT [GOC:TermGenie] synonym: "regulation of tactition, sensory detection of mechanical stimulus" EXACT [GOC:TermGenie] is_a: GO:0032101 ! regulation of response to external stimulus is_a: GO:0051931 ! regulation of sensory perception intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0050976 ! regulates detection of mechanical stimulus involved in sensory perception of touch relationship: RO:0002211 GO:0050976 ! regulates detection of mechanical stimulus involved in sensory perception of touch creation_date: 2017-01-09T15:11:04Z [Term] id: GO:1905788 name: negative regulation of detection of mechanical stimulus involved in sensory perception of touch namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of detection of mechanical stimulus involved in sensory perception of touch." [GO_REF:0000058, GOC:TermGenie, PMID:8692859] synonym: "down regulation of detection of mechanical stimulus involved in sensory perception of touch" EXACT [GOC:TermGenie] synonym: "down regulation of perception of touch, detection of mechanical stimulus" EXACT [GOC:TermGenie] synonym: "down regulation of perception of touch, sensory detection of mechanical stimulus" EXACT [GOC:TermGenie] synonym: "down regulation of perception of touch, sensory transduction of mechanical stimulus" EXACT [GOC:TermGenie] synonym: "down regulation of sensory detection of mechanical stimulus during perception of touch" EXACT [GOC:TermGenie] synonym: "down regulation of sensory transduction of mechanical stimulus during perception of touch" EXACT [GOC:TermGenie] synonym: "down regulation of tactition, sensory detection of mechanical stimulus" EXACT [GOC:TermGenie] synonym: "down-regulation of detection of mechanical stimulus involved in sensory perception of touch" EXACT [GOC:TermGenie] synonym: "down-regulation of perception of touch, detection of mechanical stimulus" EXACT [GOC:TermGenie] synonym: "down-regulation of perception of touch, sensory detection of mechanical stimulus" EXACT [GOC:TermGenie] synonym: "down-regulation of perception of touch, sensory transduction of mechanical stimulus" EXACT [GOC:TermGenie] synonym: "down-regulation of sensory detection of mechanical stimulus during perception of touch" EXACT [GOC:TermGenie] synonym: "down-regulation of sensory transduction of mechanical stimulus during perception of touch" EXACT [GOC:TermGenie] synonym: "down-regulation of tactition, sensory detection of mechanical stimulus" EXACT [GOC:TermGenie] synonym: "downregulation of detection of mechanical stimulus involved in sensory perception of touch" EXACT [GOC:TermGenie] synonym: "downregulation of perception of touch, detection of mechanical stimulus" EXACT [GOC:TermGenie] synonym: "downregulation of perception of touch, sensory detection of mechanical stimulus" EXACT [GOC:TermGenie] synonym: "downregulation of perception of touch, sensory transduction of mechanical stimulus" EXACT [GOC:TermGenie] synonym: "downregulation of sensory detection of mechanical stimulus during perception of touch" EXACT [GOC:TermGenie] synonym: "downregulation of sensory transduction of mechanical stimulus during perception of touch" EXACT [GOC:TermGenie] synonym: "downregulation of tactition, sensory detection of mechanical stimulus" EXACT [GOC:TermGenie] synonym: "inhibition of detection of mechanical stimulus involved in sensory perception of touch" NARROW [GOC:TermGenie] synonym: "inhibition of perception of touch, detection of mechanical stimulus" NARROW [GOC:TermGenie] synonym: "inhibition of perception of touch, sensory detection of mechanical stimulus" NARROW [GOC:TermGenie] synonym: "inhibition of perception of touch, sensory transduction of mechanical stimulus" NARROW [GOC:TermGenie] synonym: "inhibition of sensory detection of mechanical stimulus during perception of touch" NARROW [GOC:TermGenie] synonym: "inhibition of sensory transduction of mechanical stimulus during perception of touch" NARROW [GOC:TermGenie] synonym: "inhibition of tactition, sensory detection of mechanical stimulus" NARROW [GOC:TermGenie] synonym: "negative regulation of perception of touch, detection of mechanical stimulus" EXACT [GOC:TermGenie] synonym: "negative regulation of perception of touch, sensory detection of mechanical stimulus" EXACT [GOC:TermGenie] synonym: "negative regulation of perception of touch, sensory transduction of mechanical stimulus" EXACT [GOC:TermGenie] synonym: "negative regulation of sensory detection of mechanical stimulus during perception of touch" EXACT [GOC:TermGenie] synonym: "negative regulation of sensory transduction of mechanical stimulus during perception of touch" EXACT [GOC:TermGenie] synonym: "negative regulation of tactition, sensory detection of mechanical stimulus" EXACT [GOC:TermGenie] is_a: GO:0031645 ! negative regulation of nervous system process is_a: GO:0032102 ! negative regulation of response to external stimulus is_a: GO:1905787 ! regulation of detection of mechanical stimulus involved in sensory perception of touch intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0050976 ! negatively regulates detection of mechanical stimulus involved in sensory perception of touch relationship: RO:0002212 GO:0050976 ! negatively regulates detection of mechanical stimulus involved in sensory perception of touch creation_date: 2017-01-09T15:11:14Z [Term] id: GO:1905789 name: positive regulation of detection of mechanical stimulus involved in sensory perception of touch namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of detection of mechanical stimulus involved in sensory perception of touch." [GO_REF:0000058, GOC:TermGenie, PMID:8692859] synonym: "activation of detection of mechanical stimulus involved in sensory perception of touch" NARROW [GOC:TermGenie] synonym: "activation of perception of touch, detection of mechanical stimulus" NARROW [GOC:TermGenie] synonym: "activation of perception of touch, sensory detection of mechanical stimulus" NARROW [GOC:TermGenie] synonym: "activation of perception of touch, sensory transduction of mechanical stimulus" NARROW [GOC:TermGenie] synonym: "activation of sensory detection of mechanical stimulus during perception of touch" NARROW [GOC:TermGenie] synonym: "activation of sensory transduction of mechanical stimulus during perception of touch" NARROW [GOC:TermGenie] synonym: "activation of tactition, sensory detection of mechanical stimulus" NARROW [GOC:TermGenie] synonym: "positive regulation of perception of touch, detection of mechanical stimulus" EXACT [GOC:TermGenie] synonym: "positive regulation of perception of touch, sensory detection of mechanical stimulus" EXACT [GOC:TermGenie] synonym: "positive regulation of perception of touch, sensory transduction of mechanical stimulus" EXACT [GOC:TermGenie] synonym: "positive regulation of sensory detection of mechanical stimulus during perception of touch" EXACT [GOC:TermGenie] synonym: "positive regulation of sensory transduction of mechanical stimulus during perception of touch" EXACT [GOC:TermGenie] synonym: "positive regulation of tactition, sensory detection of mechanical stimulus" EXACT [GOC:TermGenie] synonym: "up regulation of detection of mechanical stimulus involved in sensory perception of touch" EXACT [GOC:TermGenie] synonym: "up regulation of perception of touch, detection of mechanical stimulus" EXACT [GOC:TermGenie] synonym: "up regulation of perception of touch, sensory detection of mechanical stimulus" EXACT [GOC:TermGenie] synonym: "up regulation of perception of touch, sensory transduction of mechanical stimulus" EXACT [GOC:TermGenie] synonym: "up regulation of sensory detection of mechanical stimulus during perception of touch" EXACT [GOC:TermGenie] synonym: "up regulation of sensory transduction of mechanical stimulus during perception of touch" EXACT [GOC:TermGenie] synonym: "up regulation of tactition, sensory detection of mechanical stimulus" EXACT [GOC:TermGenie] synonym: "up-regulation of detection of mechanical stimulus involved in sensory perception of touch" EXACT [GOC:TermGenie] synonym: "up-regulation of perception of touch, detection of mechanical stimulus" EXACT [GOC:TermGenie] synonym: "up-regulation of perception of touch, sensory detection of mechanical stimulus" EXACT [GOC:TermGenie] synonym: "up-regulation of perception of touch, sensory transduction of mechanical stimulus" EXACT [GOC:TermGenie] synonym: "up-regulation of sensory detection of mechanical stimulus during perception of touch" EXACT [GOC:TermGenie] synonym: "up-regulation of sensory transduction of mechanical stimulus during perception of touch" EXACT [GOC:TermGenie] synonym: "up-regulation of tactition, sensory detection of mechanical stimulus" EXACT [GOC:TermGenie] synonym: "upregulation of detection of mechanical stimulus involved in sensory perception of touch" EXACT [GOC:TermGenie] synonym: "upregulation of perception of touch, detection of mechanical stimulus" EXACT [GOC:TermGenie] synonym: "upregulation of perception of touch, sensory detection of mechanical stimulus" EXACT [GOC:TermGenie] synonym: "upregulation of perception of touch, sensory transduction of mechanical stimulus" EXACT [GOC:TermGenie] synonym: "upregulation of sensory detection of mechanical stimulus during perception of touch" EXACT [GOC:TermGenie] synonym: "upregulation of sensory transduction of mechanical stimulus during perception of touch" EXACT [GOC:TermGenie] synonym: "upregulation of tactition, sensory detection of mechanical stimulus" EXACT [GOC:TermGenie] is_a: GO:0031646 ! positive regulation of nervous system process is_a: GO:0032103 ! positive regulation of response to external stimulus is_a: GO:1905787 ! regulation of detection of mechanical stimulus involved in sensory perception of touch intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0050976 ! positively regulates detection of mechanical stimulus involved in sensory perception of touch relationship: RO:0002213 GO:0050976 ! positively regulates detection of mechanical stimulus involved in sensory perception of touch creation_date: 2017-01-09T15:11:23Z [Term] id: GO:1905805 name: excitatory synapse pruning namespace: biological_process def: "The disaggregation of an excitatory synapse into its constituent components." [GO_REF:0000079, GOC:TermGenie, PMID:27779093] synonym: "synapse clearance" BROAD [] synonym: "synapse disassembly" BROAD [] synonym: "synapse elimination" BROAD [] synonym: "synapse removal" BROAD [] is_a: GO:0098883 ! synapse pruning intersection_of: GO:0022411 ! cellular component disassembly intersection_of: RO:0002590 GO:0060076 ! results in disassembly of excitatory synapse relationship: RO:0002590 GO:0060076 ! results in disassembly of excitatory synapse creation_date: 2017-01-11T22:03:06Z [Term] id: GO:1905806 name: regulation of synapse pruning namespace: biological_process def: "Any process that modulates the frequency, rate or extent of synapse pruning." [GO_REF:0000058, GOC:TermGenie, PMID:27779093] subset: goslim_synapse synonym: "regulation of synapse clearance" EXACT [] synonym: "regulation of synapse disassembly" EXACT syngo_official_label [] synonym: "regulation of synapse elimination" EXACT [] synonym: "regulation of synapse removal" EXACT [] is_a: GO:0050807 ! regulation of synapse organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0098883 ! regulates synapse pruning relationship: RO:0002211 GO:0098883 ! regulates synapse pruning creation_date: 2017-01-11T22:03:15Z [Term] id: GO:1905807 name: negative regulation of synapse pruning namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of synapse pruning." [GO_REF:0000058, GOC:TermGenie, PMID:27779093] synonym: "down regulation of synapse disassembly" EXACT [GOC:TermGenie] synonym: "down-regulation of synapse disassembly" EXACT [GOC:TermGenie] synonym: "downregulation of synapse disassembly" EXACT [GOC:TermGenie] synonym: "inhibition of synapse disassembly" NARROW [GOC:TermGenie] synonym: "regulation of synapse clearance" BROAD [] synonym: "regulation of synapse disassembly" BROAD [] synonym: "regulation of synapse elimination" BROAD [] synonym: "regulation of synapse removal" BROAD [] is_a: GO:1905806 ! regulation of synapse pruning is_a: GO:1905809 ! negative regulation of synapse organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0098883 ! negatively regulates synapse pruning relationship: RO:0002212 GO:0098883 ! negatively regulates synapse pruning creation_date: 2017-01-11T22:03:24Z [Term] id: GO:1905808 name: positive regulation of synapse pruning namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of synapse pruning." [GO_REF:0000058, GOC:TermGenie, PMID:27779093] synonym: "activation of synapse disassembly" NARROW [GOC:TermGenie] synonym: "regulation of synapse clearance" BROAD [] synonym: "regulation of synapse disassembly" BROAD [] synonym: "regulation of synapse elimination" BROAD [] synonym: "regulation of synapse removal" BROAD [] synonym: "up regulation of synapse disassembly" EXACT [GOC:TermGenie] synonym: "up-regulation of synapse disassembly" EXACT [GOC:TermGenie] synonym: "upregulation of synapse disassembly" EXACT [GOC:TermGenie] is_a: GO:0051130 ! positive regulation of cellular component organization is_a: GO:1905806 ! regulation of synapse pruning intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0098883 ! positively regulates synapse pruning relationship: RO:0002213 GO:0098883 ! positively regulates synapse pruning creation_date: 2017-01-11T22:03:33Z [Term] id: GO:1905809 name: negative regulation of synapse organization namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of synapse organization." [GO_REF:0000058, GOC:TermGenie, PMID:27779093] synonym: "down regulation of synapse development" EXACT [GOC:TermGenie] synonym: "down regulation of synapse morphogenesis" RELATED [GOC:TermGenie] synonym: "down regulation of synapse organisation" EXACT [GOC:TermGenie] synonym: "down regulation of synapse organization" EXACT [GOC:TermGenie] synonym: "down regulation of synapse organization and biogenesis" RELATED [GOC:TermGenie] synonym: "down-regulation of synapse development" EXACT [GOC:TermGenie] synonym: "down-regulation of synapse morphogenesis" RELATED [GOC:TermGenie] synonym: "down-regulation of synapse organisation" EXACT [GOC:TermGenie] synonym: "down-regulation of synapse organization" EXACT [GOC:TermGenie] synonym: "down-regulation of synapse organization and biogenesis" RELATED [GOC:TermGenie] synonym: "downregulation of synapse development" EXACT [GOC:TermGenie] synonym: "downregulation of synapse morphogenesis" RELATED [GOC:TermGenie] synonym: "downregulation of synapse organisation" EXACT [GOC:TermGenie] synonym: "downregulation of synapse organization" EXACT [GOC:TermGenie] synonym: "downregulation of synapse organization and biogenesis" RELATED [GOC:TermGenie] synonym: "inhibition of synapse development" NARROW [GOC:TermGenie] synonym: "inhibition of synapse morphogenesis" RELATED [GOC:TermGenie] synonym: "inhibition of synapse organisation" NARROW [GOC:TermGenie] synonym: "inhibition of synapse organization" NARROW [GOC:TermGenie] synonym: "inhibition of synapse organization and biogenesis" RELATED [GOC:TermGenie] synonym: "negative regulation of synapse development" EXACT [GOC:TermGenie] synonym: "negative regulation of synapse morphogenesis" RELATED [GOC:TermGenie] synonym: "negative regulation of synapse organisation" EXACT [GOC:TermGenie] synonym: "negative regulation of synapse organization and biogenesis" RELATED [GOC:TermGenie] is_a: GO:0050807 ! regulation of synapse organization is_a: GO:0051129 ! negative regulation of cellular component organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0050808 ! negatively regulates synapse organization relationship: RO:0002212 GO:0050808 ! negatively regulates synapse organization creation_date: 2017-01-11T22:03:41Z [Term] id: GO:1905810 name: regulation of excitatory synapse pruning namespace: biological_process def: "Any process that modulates the frequency, rate or extent of excitatory synapse pruning." [GO_REF:0000058, GOC:TermGenie, PMID:27779093] synonym: "regulation of synapse clearance" BROAD [] synonym: "regulation of synapse disassembly" BROAD [] synonym: "regulation of synapse elimination" BROAD [] synonym: "regulation of synapse removal" BROAD [] is_a: GO:1905806 ! regulation of synapse pruning intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:1905805 ! regulates excitatory synapse pruning relationship: RO:0002211 GO:1905805 ! regulates excitatory synapse pruning creation_date: 2017-01-12T02:38:27Z [Term] id: GO:1905811 name: negative regulation of excitatory synapse pruning namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of excitatory synapse pruning." [GO_REF:0000058, GOC:TermGenie, PMID:27779093] synonym: "down regulation of excitatory synapse disassembly" EXACT [GOC:TermGenie] synonym: "down-regulation of excitatory synapse disassembly" EXACT [GOC:TermGenie] synonym: "downregulation of excitatory synapse disassembly" EXACT [GOC:TermGenie] synonym: "inhibition of excitatory synapse disassembly" NARROW [GOC:TermGenie] synonym: "regulation of synapse clearance" BROAD [] synonym: "regulation of synapse disassembly" BROAD [] synonym: "regulation of synapse elimination" BROAD [] synonym: "regulation of synapse removal" BROAD [] is_a: GO:1905807 ! negative regulation of synapse pruning is_a: GO:1905810 ! regulation of excitatory synapse pruning intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:1905805 ! negatively regulates excitatory synapse pruning relationship: RO:0002212 GO:1905805 ! negatively regulates excitatory synapse pruning creation_date: 2017-01-12T02:38:36Z [Term] id: GO:1905821 name: positive regulation of chromosome condensation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of chromosome condensation." [GO_REF:0000058, GOC:bhm, GOC:TermGenie, PMID:17268547] synonym: "activation of chromosome condensation" NARROW [GOC:TermGenie] synonym: "activation of eukaryotic chromosome condensation" NARROW [GOC:TermGenie] synonym: "activation of nuclear chromosome condensation" NARROW [GOC:TermGenie] synonym: "positive regulation of eukaryotic chromosome condensation" EXACT [GOC:TermGenie] synonym: "positive regulation of nuclear chromosome condensation" EXACT [GOC:TermGenie] synonym: "up regulation of chromosome condensation" EXACT [GOC:TermGenie] synonym: "up regulation of eukaryotic chromosome condensation" EXACT [GOC:TermGenie] synonym: "up regulation of nuclear chromosome condensation" EXACT [GOC:TermGenie] synonym: "up-regulation of chromosome condensation" EXACT [GOC:TermGenie] synonym: "up-regulation of eukaryotic chromosome condensation" EXACT [GOC:TermGenie] synonym: "up-regulation of nuclear chromosome condensation" EXACT [GOC:TermGenie] synonym: "upregulation of chromosome condensation" EXACT [GOC:TermGenie] synonym: "upregulation of eukaryotic chromosome condensation" EXACT [GOC:TermGenie] synonym: "upregulation of nuclear chromosome condensation" EXACT [GOC:TermGenie] is_a: GO:0060623 ! regulation of chromosome condensation is_a: GO:2001252 ! positive regulation of chromosome organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0030261 ! positively regulates chromosome condensation relationship: RO:0002213 GO:0030261 ! positively regulates chromosome condensation creation_date: 2017-01-13T14:13:44Z [Term] id: GO:1905833 name: negative regulation of microtubule nucleation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of microtubule nucleation." [GO_REF:0000058, GOC:TermGenie, PMID:27689799] synonym: "down regulation of microtubule nucleation" EXACT [GOC:TermGenie] synonym: "down-regulation of microtubule nucleation" EXACT [GOC:TermGenie] synonym: "downregulation of microtubule nucleation" EXACT [GOC:TermGenie] synonym: "inhibition of microtubule nucleation" NARROW [GOC:TermGenie] is_a: GO:0010968 ! regulation of microtubule nucleation is_a: GO:0031115 ! negative regulation of microtubule polymerization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0007020 ! negatively regulates microtubule nucleation relationship: RO:0002212 GO:0007020 ! negatively regulates microtubule nucleation creation_date: 2017-01-17T12:00:56Z [Term] id: GO:1905867 name: epididymis development namespace: biological_process def: "The process whose specific outcome is the progression of an epididymis over time, from its formation to the mature structure." [GO_REF:0000094, GOC:TermGenie, PMID:12388089] synonym: "epididymus development" EXACT [GOC:TermGenie] is_a: GO:0035295 ! tube development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0001301 ! results in development of epididymis relationship: RO:0002162 NCBITaxon:7776 ! in taxon Gnathostomata relationship: RO:0002296 UBERON:0001301 ! results in development of epididymis creation_date: 2017-01-27T00:00:33Z [Term] id: GO:1905871 name: regulation of protein localization to cell leading edge namespace: biological_process def: "Any process that modulates the frequency, rate or extent of protein localization to cell leading edge." [GO_REF:0000058, GOC:TermGenie, PMID:26324884] synonym: "regulation of protein localisation in cell leading edge" EXACT [GOC:TermGenie] synonym: "regulation of protein localisation to cell leading edge" EXACT [GOC:TermGenie] synonym: "regulation of protein localization in cell leading edge" EXACT [GOC:TermGenie] is_a: GO:0032880 ! regulation of protein localization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:1902463 ! regulates protein localization to cell leading edge relationship: RO:0002211 GO:1902463 ! regulates protein localization to cell leading edge creation_date: 2017-01-27T19:34:55Z [Term] id: GO:1905872 name: negative regulation of protein localization to cell leading edge namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to cell leading edge." [GO_REF:0000058, GOC:TermGenie, PMID:26324884] synonym: "down regulation of protein localisation in cell leading edge" EXACT [GOC:TermGenie] synonym: "down regulation of protein localisation to cell leading edge" EXACT [GOC:TermGenie] synonym: "down regulation of protein localization in cell leading edge" EXACT [GOC:TermGenie] synonym: "down regulation of protein localization to cell leading edge" EXACT [GOC:TermGenie] synonym: "down-regulation of protein localisation in cell leading edge" EXACT [GOC:TermGenie] synonym: "down-regulation of protein localisation to cell leading edge" EXACT [GOC:TermGenie] synonym: "down-regulation of protein localization in cell leading edge" EXACT [GOC:TermGenie] synonym: "down-regulation of protein localization to cell leading edge" EXACT [GOC:TermGenie] synonym: "downregulation of protein localisation in cell leading edge" EXACT [GOC:TermGenie] synonym: "downregulation of protein localisation to cell leading edge" EXACT [GOC:TermGenie] synonym: "downregulation of protein localization in cell leading edge" EXACT [GOC:TermGenie] synonym: "downregulation of protein localization to cell leading edge" EXACT [GOC:TermGenie] synonym: "inhibition of protein localisation in cell leading edge" NARROW [GOC:TermGenie] synonym: "inhibition of protein localisation to cell leading edge" NARROW [GOC:TermGenie] synonym: "inhibition of protein localization in cell leading edge" NARROW [GOC:TermGenie] synonym: "inhibition of protein localization to cell leading edge" NARROW [GOC:TermGenie] synonym: "negative regulation of protein localisation in cell leading edge" EXACT [GOC:TermGenie] synonym: "negative regulation of protein localisation to cell leading edge" EXACT [GOC:TermGenie] synonym: "negative regulation of protein localization in cell leading edge" EXACT [GOC:TermGenie] is_a: GO:1903828 ! negative regulation of protein localization is_a: GO:1905871 ! regulation of protein localization to cell leading edge intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:1902463 ! negatively regulates protein localization to cell leading edge relationship: RO:0002212 GO:1902463 ! negatively regulates protein localization to cell leading edge creation_date: 2017-01-27T19:35:04Z [Term] id: GO:1905873 name: positive regulation of protein localization to cell leading edge namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of protein localization to cell leading edge." [GO_REF:0000058, GOC:TermGenie, PMID:26324884] synonym: "activation of protein localisation in cell leading edge" NARROW [GOC:TermGenie] synonym: "activation of protein localisation to cell leading edge" NARROW [GOC:TermGenie] synonym: "activation of protein localization in cell leading edge" NARROW [GOC:TermGenie] synonym: "activation of protein localization to cell leading edge" NARROW [GOC:TermGenie] synonym: "positive regulation of protein localisation in cell leading edge" EXACT [GOC:TermGenie] synonym: "positive regulation of protein localisation to cell leading edge" EXACT [GOC:TermGenie] synonym: "positive regulation of protein localization in cell leading edge" EXACT [GOC:TermGenie] synonym: "up regulation of protein localisation in cell leading edge" EXACT [GOC:TermGenie] synonym: "up regulation of protein localisation to cell leading edge" EXACT [GOC:TermGenie] synonym: "up regulation of protein localization in cell leading edge" EXACT [GOC:TermGenie] synonym: "up regulation of protein localization to cell leading edge" EXACT [GOC:TermGenie] synonym: "up-regulation of protein localisation in cell leading edge" EXACT [GOC:TermGenie] synonym: "up-regulation of protein localisation to cell leading edge" EXACT [GOC:TermGenie] synonym: "up-regulation of protein localization in cell leading edge" EXACT [GOC:TermGenie] synonym: "up-regulation of protein localization to cell leading edge" EXACT [GOC:TermGenie] synonym: "upregulation of protein localisation in cell leading edge" EXACT [GOC:TermGenie] synonym: "upregulation of protein localisation to cell leading edge" EXACT [GOC:TermGenie] synonym: "upregulation of protein localization in cell leading edge" EXACT [GOC:TermGenie] synonym: "upregulation of protein localization to cell leading edge" EXACT [GOC:TermGenie] is_a: GO:1903829 ! positive regulation of protein localization is_a: GO:1905871 ! regulation of protein localization to cell leading edge intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:1902463 ! positively regulates protein localization to cell leading edge relationship: RO:0002213 GO:1902463 ! positively regulates protein localization to cell leading edge creation_date: 2017-01-27T19:35:13Z [Term] id: GO:1905879 name: regulation of oogenesis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of oogenesis." [GO_REF:0000058, GOC:TermGenie, PMID:26434723] synonym: "regulation of ovum development" EXACT [GOC:TermGenie] is_a: GO:0051239 ! regulation of multicellular organismal process is_a: GO:0060284 ! regulation of cell development is_a: GO:2000241 ! regulation of reproductive process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0048477 ! regulates oogenesis relationship: RO:0002211 GO:0048477 ! regulates oogenesis creation_date: 2017-01-31T09:31:05Z [Term] id: GO:1905880 name: negative regulation of oogenesis namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of oogenesis." [GO_REF:0000058, GOC:TermGenie, PMID:26434723] synonym: "down regulation of oogenesis" EXACT [GOC:TermGenie] synonym: "down regulation of ovum development" EXACT [GOC:TermGenie] synonym: "down-regulation of oogenesis" EXACT [GOC:TermGenie] synonym: "down-regulation of ovum development" EXACT [GOC:TermGenie] synonym: "downregulation of oogenesis" EXACT [GOC:TermGenie] synonym: "downregulation of ovum development" EXACT [GOC:TermGenie] synonym: "inhibition of oogenesis" NARROW [GOC:TermGenie] synonym: "inhibition of ovum development" NARROW [GOC:TermGenie] synonym: "negative regulation of ovum development" EXACT [GOC:TermGenie] is_a: GO:0010721 ! negative regulation of cell development is_a: GO:0051241 ! negative regulation of multicellular organismal process is_a: GO:1905879 ! regulation of oogenesis is_a: GO:2000242 ! negative regulation of reproductive process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0048477 ! negatively regulates oogenesis relationship: RO:0002212 GO:0048477 ! negatively regulates oogenesis creation_date: 2017-01-31T09:31:15Z [Term] id: GO:1905881 name: positive regulation of oogenesis namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of oogenesis." [GO_REF:0000058, GOC:TermGenie, PMID:26434723] synonym: "activation of oogenesis" NARROW [GOC:TermGenie] synonym: "activation of ovum development" NARROW [GOC:TermGenie] synonym: "positive regulation of ovum development" EXACT [GOC:TermGenie] synonym: "up regulation of oogenesis" EXACT [GOC:TermGenie] synonym: "up regulation of ovum development" EXACT [GOC:TermGenie] synonym: "up-regulation of oogenesis" EXACT [GOC:TermGenie] synonym: "up-regulation of ovum development" EXACT [GOC:TermGenie] synonym: "upregulation of oogenesis" EXACT [GOC:TermGenie] synonym: "upregulation of ovum development" EXACT [GOC:TermGenie] is_a: GO:0010720 ! positive regulation of cell development is_a: GO:0051240 ! positive regulation of multicellular organismal process is_a: GO:1905879 ! regulation of oogenesis is_a: GO:2000243 ! positive regulation of reproductive process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0048477 ! positively regulates oogenesis relationship: RO:0002213 GO:0048477 ! positively regulates oogenesis creation_date: 2017-01-31T09:31:23Z [Term] id: GO:1905899 name: regulation of smooth muscle tissue development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of smooth muscle tissue development." [GO_REF:0000058, GOC:bhm, GOC:TermGenie, PMID:14709716] is_a: GO:1901861 ! regulation of muscle tissue development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0048745 ! regulates smooth muscle tissue development relationship: RO:0002211 GO:0048745 ! regulates smooth muscle tissue development creation_date: 2017-02-01T14:31:16Z [Term] id: GO:1905900 name: negative regulation of smooth muscle tissue development namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of smooth muscle tissue development." [GO_REF:0000058, GOC:bhm, GOC:TermGenie, PMID:14709716] synonym: "down regulation of smooth muscle tissue development" EXACT [GOC:TermGenie] synonym: "down-regulation of smooth muscle tissue development" EXACT [GOC:TermGenie] synonym: "downregulation of smooth muscle tissue development" EXACT [GOC:TermGenie] synonym: "inhibition of smooth muscle tissue development" NARROW [GOC:TermGenie] is_a: GO:1901862 ! negative regulation of muscle tissue development is_a: GO:1905899 ! regulation of smooth muscle tissue development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0048745 ! negatively regulates smooth muscle tissue development relationship: RO:0002212 GO:0048745 ! negatively regulates smooth muscle tissue development creation_date: 2017-02-01T14:31:24Z [Term] id: GO:1905901 name: positive regulation of smooth muscle tissue development namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of smooth muscle tissue development." [GO_REF:0000058, GOC:bhm, GOC:TermGenie, PMID:14709716] synonym: "activation of smooth muscle tissue development" NARROW [GOC:TermGenie] synonym: "up regulation of smooth muscle tissue development" EXACT [GOC:TermGenie] synonym: "up-regulation of smooth muscle tissue development" EXACT [GOC:TermGenie] synonym: "upregulation of smooth muscle tissue development" EXACT [GOC:TermGenie] is_a: GO:1901863 ! positive regulation of muscle tissue development is_a: GO:1905899 ! regulation of smooth muscle tissue development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0048745 ! positively regulates smooth muscle tissue development relationship: RO:0002213 GO:0048745 ! positively regulates smooth muscle tissue development creation_date: 2017-02-01T14:31:33Z [Term] id: GO:1905902 name: regulation of mesoderm formation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of mesoderm formation." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:23939491] is_a: GO:0050793 ! regulation of developmental process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0001707 ! regulates mesoderm formation relationship: RO:0002211 GO:0001707 ! regulates mesoderm formation creation_date: 2017-02-03T12:28:20Z [Term] id: GO:1905903 name: negative regulation of mesoderm formation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of mesoderm formation." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:23939491] synonym: "down regulation of mesoderm formation" EXACT [GOC:TermGenie] synonym: "down-regulation of mesoderm formation" EXACT [GOC:TermGenie] synonym: "downregulation of mesoderm formation" EXACT [GOC:TermGenie] synonym: "inhibition of mesoderm formation" NARROW [GOC:TermGenie] is_a: GO:1905902 ! regulation of mesoderm formation is_a: GO:2000381 ! negative regulation of mesoderm development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0001707 ! negatively regulates mesoderm formation relationship: RO:0002212 GO:0001707 ! negatively regulates mesoderm formation creation_date: 2017-02-03T12:28:29Z [Term] id: GO:1905904 name: positive regulation of mesoderm formation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of mesoderm formation." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:23939491] synonym: "activation of mesoderm formation" NARROW [GOC:TermGenie] synonym: "up regulation of mesoderm formation" EXACT [GOC:TermGenie] synonym: "up-regulation of mesoderm formation" EXACT [GOC:TermGenie] synonym: "upregulation of mesoderm formation" EXACT [GOC:TermGenie] is_a: GO:1905902 ! regulation of mesoderm formation is_a: GO:2000382 ! positive regulation of mesoderm development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0001707 ! positively regulates mesoderm formation relationship: RO:0002213 GO:0001707 ! positively regulates mesoderm formation creation_date: 2017-02-03T12:28:38Z [Term] id: GO:1905912 name: regulation of calcium ion export across plasma membrane namespace: biological_process def: "Any process that modulates the frequency, rate or extent of calcium ion export across the plasma membrane." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:22362515] synonym: "regulation of calcium ion efflux from cell" EXACT [GOC:TermGenie] synonym: "regulation of calcium ion export from cell" EXACT [] is_a: GO:1903169 ! regulation of calcium ion transmembrane transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:1990034 ! regulates calcium ion export across plasma membrane relationship: RO:0002211 GO:1990034 ! regulates calcium ion export across plasma membrane creation_date: 2017-02-07T13:20:39Z [Term] id: GO:1905913 name: negative regulation of calcium ion export across plasma membrane namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of calcium ion export across the plasma membrane." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:22362515] synonym: "down regulation of calcium ion efflux from cell" EXACT [GOC:TermGenie] synonym: "down regulation of calcium ion export from cell" EXACT [GOC:TermGenie] synonym: "down-regulation of calcium ion efflux from cell" EXACT [GOC:TermGenie] synonym: "down-regulation of calcium ion export from cell" EXACT [GOC:TermGenie] synonym: "downregulation of calcium ion efflux from cell" EXACT [GOC:TermGenie] synonym: "downregulation of calcium ion export from cell" EXACT [GOC:TermGenie] synonym: "inhibition of calcium ion efflux from cell" NARROW [GOC:TermGenie] synonym: "inhibition of calcium ion export from cell" NARROW [GOC:TermGenie] synonym: "negative regulation of calcium ion efflux from cell" EXACT [GOC:TermGenie] synonym: "negative regulation of calcium ion export from cell" EXACT [] is_a: GO:1903170 ! negative regulation of calcium ion transmembrane transport is_a: GO:1905912 ! regulation of calcium ion export across plasma membrane intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:1990034 ! negatively regulates calcium ion export across plasma membrane relationship: RO:0002212 GO:1990034 ! negatively regulates calcium ion export across plasma membrane creation_date: 2017-02-07T13:20:48Z [Term] id: GO:1905914 name: positive regulation of calcium ion export across plasma membrane namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of calcium ion export across the plasma membrane." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:22362515] synonym: "activation of calcium ion efflux from cell" NARROW [GOC:TermGenie] synonym: "activation of calcium ion export from cell" NARROW [GOC:TermGenie] synonym: "positive regulation of calcium ion efflux from cell" EXACT [GOC:TermGenie] synonym: "positive regulation of calcium ion export from cell" EXACT [] synonym: "up regulation of calcium ion efflux from cell" EXACT [GOC:TermGenie] synonym: "up regulation of calcium ion export from cell" EXACT [GOC:TermGenie] synonym: "up-regulation of calcium ion efflux from cell" EXACT [GOC:TermGenie] synonym: "up-regulation of calcium ion export from cell" EXACT [GOC:TermGenie] synonym: "upregulation of calcium ion efflux from cell" EXACT [GOC:TermGenie] synonym: "upregulation of calcium ion export from cell" EXACT [GOC:TermGenie] is_a: GO:1904427 ! positive regulation of calcium ion transmembrane transport is_a: GO:1905912 ! regulation of calcium ion export across plasma membrane intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:1990034 ! positively regulates calcium ion export across plasma membrane relationship: RO:0002213 GO:1990034 ! positively regulates calcium ion export across plasma membrane creation_date: 2017-02-07T13:20:56Z [Term] id: GO:1905921 name: regulation of acetylcholine biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of acetylcholine biosynthetic process." [GO_REF:0000058, GOC:aruk, GOC:bc, GOC:TermGenie, PMID:20164328] synonym: "regulation of acetylcholine anabolism" EXACT [GOC:TermGenie] synonym: "regulation of acetylcholine biosynthesis" EXACT [GOC:TermGenie] synonym: "regulation of acetylcholine formation" EXACT [GOC:TermGenie] synonym: "regulation of acetylcholine synthesis" EXACT [GOC:TermGenie] is_a: GO:0009889 ! regulation of biosynthetic process is_a: GO:0060408 ! regulation of acetylcholine metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0008292 ! regulates acetylcholine biosynthetic process relationship: RO:0002211 GO:0008292 ! regulates acetylcholine biosynthetic process creation_date: 2017-02-08T13:08:30Z [Term] id: GO:1905922 name: negative regulation of acetylcholine biosynthetic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of acetylcholine biosynthetic process." [GO_REF:0000058, GOC:aruk, GOC:bc, GOC:TermGenie, PMID:20164328] synonym: "down regulation of acetylcholine anabolism" EXACT [GOC:TermGenie] synonym: "down regulation of acetylcholine biosynthesis" EXACT [GOC:TermGenie] synonym: "down regulation of acetylcholine biosynthetic process" EXACT [GOC:TermGenie] synonym: "down regulation of acetylcholine formation" EXACT [GOC:TermGenie] synonym: "down regulation of acetylcholine synthesis" EXACT [GOC:TermGenie] synonym: "down-regulation of acetylcholine anabolism" EXACT [GOC:TermGenie] synonym: "down-regulation of acetylcholine biosynthesis" EXACT [GOC:TermGenie] synonym: "down-regulation of acetylcholine biosynthetic process" EXACT [GOC:TermGenie] synonym: "down-regulation of acetylcholine formation" EXACT [GOC:TermGenie] synonym: "down-regulation of acetylcholine synthesis" EXACT [GOC:TermGenie] synonym: "downregulation of acetylcholine anabolism" EXACT [GOC:TermGenie] synonym: "downregulation of acetylcholine biosynthesis" EXACT [GOC:TermGenie] synonym: "downregulation of acetylcholine biosynthetic process" EXACT [GOC:TermGenie] synonym: "downregulation of acetylcholine formation" EXACT [GOC:TermGenie] synonym: "downregulation of acetylcholine synthesis" EXACT [GOC:TermGenie] synonym: "inhibition of acetylcholine anabolism" NARROW [GOC:TermGenie] synonym: "inhibition of acetylcholine biosynthesis" NARROW [GOC:TermGenie] synonym: "inhibition of acetylcholine biosynthetic process" NARROW [GOC:TermGenie] synonym: "inhibition of acetylcholine formation" NARROW [GOC:TermGenie] synonym: "inhibition of acetylcholine synthesis" NARROW [GOC:TermGenie] synonym: "negative regulation of acetylcholine anabolism" EXACT [GOC:TermGenie] synonym: "negative regulation of acetylcholine biosynthesis" EXACT [GOC:TermGenie] synonym: "negative regulation of acetylcholine formation" EXACT [GOC:TermGenie] synonym: "negative regulation of acetylcholine synthesis" EXACT [GOC:TermGenie] is_a: GO:0009890 ! negative regulation of biosynthetic process is_a: GO:1905921 ! regulation of acetylcholine biosynthetic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0008292 ! negatively regulates acetylcholine biosynthetic process relationship: RO:0002212 GO:0008292 ! negatively regulates acetylcholine biosynthetic process creation_date: 2017-02-08T13:08:39Z [Term] id: GO:1905923 name: positive regulation of acetylcholine biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of acetylcholine biosynthetic process." [GO_REF:0000058, GOC:aruk, GOC:bc, GOC:TermGenie, PMID:20164328] synonym: "activation of acetylcholine anabolism" NARROW [GOC:TermGenie] synonym: "activation of acetylcholine biosynthesis" NARROW [GOC:TermGenie] synonym: "activation of acetylcholine biosynthetic process" NARROW [GOC:TermGenie] synonym: "activation of acetylcholine formation" NARROW [GOC:TermGenie] synonym: "activation of acetylcholine synthesis" NARROW [GOC:TermGenie] synonym: "positive regulation of acetylcholine anabolism" EXACT [GOC:TermGenie] synonym: "positive regulation of acetylcholine biosynthesis" EXACT [GOC:TermGenie] synonym: "positive regulation of acetylcholine formation" EXACT [GOC:TermGenie] synonym: "positive regulation of acetylcholine synthesis" EXACT [GOC:TermGenie] synonym: "up regulation of acetylcholine anabolism" EXACT [GOC:TermGenie] synonym: "up regulation of acetylcholine biosynthesis" EXACT [GOC:TermGenie] synonym: "up regulation of acetylcholine biosynthetic process" EXACT [GOC:TermGenie] synonym: "up regulation of acetylcholine formation" EXACT [GOC:TermGenie] synonym: "up regulation of acetylcholine synthesis" EXACT [GOC:TermGenie] synonym: "up-regulation of acetylcholine anabolism" EXACT [GOC:TermGenie] synonym: "up-regulation of acetylcholine biosynthesis" EXACT [GOC:TermGenie] synonym: "up-regulation of acetylcholine biosynthetic process" EXACT [GOC:TermGenie] synonym: "up-regulation of acetylcholine formation" EXACT [GOC:TermGenie] synonym: "up-regulation of acetylcholine synthesis" EXACT [GOC:TermGenie] synonym: "upregulation of acetylcholine anabolism" EXACT [GOC:TermGenie] synonym: "upregulation of acetylcholine biosynthesis" EXACT [GOC:TermGenie] synonym: "upregulation of acetylcholine biosynthetic process" EXACT [GOC:TermGenie] synonym: "upregulation of acetylcholine formation" EXACT [GOC:TermGenie] synonym: "upregulation of acetylcholine synthesis" EXACT [GOC:TermGenie] is_a: GO:0009891 ! positive regulation of biosynthetic process is_a: GO:0060409 ! positive regulation of acetylcholine metabolic process is_a: GO:1905921 ! regulation of acetylcholine biosynthetic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0008292 ! positively regulates acetylcholine biosynthetic process relationship: RO:0002213 GO:0008292 ! positively regulates acetylcholine biosynthetic process creation_date: 2017-02-08T13:08:48Z [Term] id: GO:1905936 name: regulation of germ cell proliferation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of germ cell proliferation." [GO_REF:0000058, GOC:TermGenie, PMID:15342467] is_a: GO:0042127 ! regulation of cell population proliferation is_a: GO:0051239 ! regulation of multicellular organismal process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0036093 ! regulates germ cell proliferation relationship: RO:0002211 GO:0036093 ! regulates germ cell proliferation property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4751 creation_date: 2017-02-09T14:51:31Z [Term] id: GO:1905937 name: negative regulation of germ cell proliferation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of germ cell proliferation." [GO_REF:0000058, GOC:TermGenie, PMID:15342467] synonym: "down regulation of germ cell proliferation" EXACT [GOC:TermGenie] synonym: "down-regulation of germ cell proliferation" EXACT [GOC:TermGenie] synonym: "downregulation of germ cell proliferation" EXACT [GOC:TermGenie] synonym: "inhibition of germ cell proliferation" NARROW [GOC:TermGenie] is_a: GO:0008285 ! negative regulation of cell population proliferation is_a: GO:0051241 ! negative regulation of multicellular organismal process is_a: GO:1905936 ! regulation of germ cell proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0036093 ! negatively regulates germ cell proliferation relationship: RO:0002212 GO:0036093 ! negatively regulates germ cell proliferation property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4751 creation_date: 2017-02-09T14:51:41Z [Term] id: GO:1905938 name: positive regulation of germ cell proliferation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of germ cell proliferation." [GO_REF:0000058, GOC:TermGenie, PMID:15342467] synonym: "activation of germ cell proliferation" NARROW [GOC:TermGenie] synonym: "up regulation of germ cell proliferation" EXACT [GOC:TermGenie] synonym: "up-regulation of germ cell proliferation" EXACT [GOC:TermGenie] synonym: "upregulation of germ cell proliferation" EXACT [GOC:TermGenie] is_a: GO:0008284 ! positive regulation of cell population proliferation is_a: GO:0051240 ! positive regulation of multicellular organismal process is_a: GO:1905936 ! regulation of germ cell proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0036093 ! positively regulates germ cell proliferation relationship: RO:0002213 GO:0036093 ! positively regulates germ cell proliferation property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4751 creation_date: 2017-02-09T14:51:51Z [Term] id: GO:1905939 name: regulation of gonad development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of gonad development." [GO_REF:0000058, GOC:TermGenie, PMID:15342467] synonym: "regulation of gonadogenesis" EXACT [GOC:TermGenie] is_a: GO:0050793 ! regulation of developmental process is_a: GO:2000241 ! regulation of reproductive process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0008406 ! regulates gonad development relationship: RO:0002211 GO:0008406 ! regulates gonad development property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 creation_date: 2017-02-09T17:01:50Z [Term] id: GO:1905940 name: negative regulation of gonad development namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of gonad development." [GO_REF:0000058, GOC:TermGenie, PMID:15342467] synonym: "down regulation of gonad development" EXACT [GOC:TermGenie] synonym: "down regulation of gonadogenesis" EXACT [GOC:TermGenie] synonym: "down-regulation of gonad development" EXACT [GOC:TermGenie] synonym: "down-regulation of gonadogenesis" EXACT [GOC:TermGenie] synonym: "downregulation of gonad development" EXACT [GOC:TermGenie] synonym: "downregulation of gonadogenesis" EXACT [GOC:TermGenie] synonym: "inhibition of gonad development" NARROW [GOC:TermGenie] synonym: "inhibition of gonadogenesis" NARROW [GOC:TermGenie] synonym: "negative regulation of gonadogenesis" EXACT [GOC:TermGenie] is_a: GO:0051093 ! negative regulation of developmental process is_a: GO:0051241 ! negative regulation of multicellular organismal process is_a: GO:1905939 ! regulation of gonad development is_a: GO:2000242 ! negative regulation of reproductive process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0008406 ! negatively regulates gonad development relationship: RO:0002212 GO:0008406 ! negatively regulates gonad development property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 creation_date: 2017-02-09T17:01:59Z [Term] id: GO:1905941 name: positive regulation of gonad development namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of gonad development." [GO_REF:0000058, GOC:TermGenie, PMID:15342467] synonym: "activation of gonad development" NARROW [GOC:TermGenie] synonym: "activation of gonadogenesis" NARROW [GOC:TermGenie] synonym: "positive regulation of gonadogenesis" EXACT [GOC:TermGenie] synonym: "up regulation of gonad development" EXACT [GOC:TermGenie] synonym: "up regulation of gonadogenesis" EXACT [GOC:TermGenie] synonym: "up-regulation of gonad development" EXACT [GOC:TermGenie] synonym: "up-regulation of gonadogenesis" EXACT [GOC:TermGenie] synonym: "upregulation of gonad development" EXACT [GOC:TermGenie] synonym: "upregulation of gonadogenesis" EXACT [GOC:TermGenie] is_a: GO:0051094 ! positive regulation of developmental process is_a: GO:0051240 ! positive regulation of multicellular organismal process is_a: GO:1905939 ! regulation of gonad development is_a: GO:2000243 ! positive regulation of reproductive process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0008406 ! positively regulates gonad development relationship: RO:0002213 GO:0008406 ! positively regulates gonad development property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 creation_date: 2017-02-09T17:02:08Z [Term] id: GO:1905945 name: regulation of response to calcium ion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of response to calcium ion." [GO_REF:0000058, GOC:aruk, GOC:bc, GOC:TermGenie, PMID:11404397] synonym: "regulation of response to Ca2+ ion" EXACT [GOC:TermGenie] is_a: GO:0048583 ! regulation of response to stimulus intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0051592 ! regulates response to calcium ion relationship: RO:0002211 GO:0051592 ! regulates response to calcium ion creation_date: 2017-02-13T10:56:34Z [Term] id: GO:1905946 name: negative regulation of response to calcium ion namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of response to calcium ion." [GO_REF:0000058, GOC:aruk, GOC:bc, GOC:TermGenie, PMID:11404397] synonym: "down regulation of response to Ca2+ ion" EXACT [GOC:TermGenie] synonym: "down regulation of response to calcium ion" EXACT [GOC:TermGenie] synonym: "down-regulation of response to Ca2+ ion" EXACT [GOC:TermGenie] synonym: "down-regulation of response to calcium ion" EXACT [GOC:TermGenie] synonym: "downregulation of response to Ca2+ ion" EXACT [GOC:TermGenie] synonym: "downregulation of response to calcium ion" EXACT [GOC:TermGenie] synonym: "inhibition of response to Ca2+ ion" NARROW [GOC:TermGenie] synonym: "inhibition of response to calcium ion" NARROW [GOC:TermGenie] synonym: "negative regulation of response to Ca2+ ion" EXACT [GOC:TermGenie] is_a: GO:0048585 ! negative regulation of response to stimulus is_a: GO:1905945 ! regulation of response to calcium ion intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0051592 ! negatively regulates response to calcium ion relationship: RO:0002212 GO:0051592 ! negatively regulates response to calcium ion creation_date: 2017-02-13T10:56:41Z [Term] id: GO:1905947 name: positive regulation of response to calcium ion namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of response to calcium ion." [GO_REF:0000058, GOC:aruk, GOC:bc, GOC:TermGenie, PMID:11404397] synonym: "activation of response to Ca2+ ion" NARROW [GOC:TermGenie] synonym: "activation of response to calcium ion" NARROW [GOC:TermGenie] synonym: "positive regulation of response to Ca2+ ion" EXACT [GOC:TermGenie] synonym: "up regulation of response to Ca2+ ion" EXACT [GOC:TermGenie] synonym: "up regulation of response to calcium ion" EXACT [GOC:TermGenie] synonym: "up-regulation of response to Ca2+ ion" EXACT [GOC:TermGenie] synonym: "up-regulation of response to calcium ion" EXACT [GOC:TermGenie] synonym: "upregulation of response to Ca2+ ion" EXACT [GOC:TermGenie] synonym: "upregulation of response to calcium ion" EXACT [GOC:TermGenie] is_a: GO:0048584 ! positive regulation of response to stimulus is_a: GO:1905945 ! regulation of response to calcium ion intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0051592 ! positively regulates response to calcium ion relationship: RO:0002213 GO:0051592 ! positively regulates response to calcium ion creation_date: 2017-02-13T10:56:49Z [Term] id: GO:1905949 name: negative regulation of calcium ion import across plasma membrane namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of calcium ion import across plasma membrane." [GO_REF:0000058, GOC:bhm, GOC:TermGenie, PMID:17640527] comment: An example of this is PPP3CA in human (Q08209) in PMID:17640527 (inferred from direct assay). synonym: "down regulation of calcium ion import across plasma membrane" EXACT [GOC:TermGenie] synonym: "down-regulation of calcium ion import across plasma membrane" EXACT [GOC:TermGenie] synonym: "downregulation of calcium ion import across plasma membrane" EXACT [GOC:TermGenie] synonym: "inhibition of calcium ion import across plasma membrane" NARROW [GOC:TermGenie] is_a: GO:0090281 ! negative regulation of calcium ion import is_a: GO:1903170 ! negative regulation of calcium ion transmembrane transport is_a: GO:1905664 ! regulation of calcium ion import across plasma membrane intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0098703 ! negatively regulates calcium ion import across plasma membrane relationship: RO:0002212 GO:0098703 ! negatively regulates calcium ion import across plasma membrane creation_date: 2017-02-17T09:42:30Z [Term] id: GO:1905951 name: mitochondrion DNA recombination namespace: biological_process def: "Any DNA recombination that takes place in mitochondrion." [GO_REF:0000062, GOC:TermGenie, PMID:8087883] synonym: "DNA recombination in mitochondria" EXACT [GOC:TermGenie] is_a: GO:0006310 ! DNA recombination is_a: GO:0032042 ! mitochondrial DNA metabolic process intersection_of: GO:0006310 ! DNA recombination intersection_of: BFO:0000066 GO:0005739 ! occurs in mitochondrion creation_date: 2017-02-19T10:48:17Z [Term] id: GO:1905952 name: regulation of lipid localization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of lipid localization." [GO_REF:0000058, GOC:TermGenie, PMID:17564681] synonym: "regulation of lipid localisation" EXACT [GOC:TermGenie] is_a: GO:0032879 ! regulation of localization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0010876 ! regulates lipid localization relationship: RO:0002211 GO:0010876 ! regulates lipid localization creation_date: 2017-02-21T12:12:22Z [Term] id: GO:1905953 name: negative regulation of lipid localization namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of lipid localization." [GO_REF:0000058, GOC:TermGenie, PMID:17564681] synonym: "down regulation of lipid localisation" EXACT [GOC:TermGenie] synonym: "down regulation of lipid localization" EXACT [GOC:TermGenie] synonym: "down-regulation of lipid localisation" EXACT [GOC:TermGenie] synonym: "down-regulation of lipid localization" EXACT [GOC:TermGenie] synonym: "downregulation of lipid localisation" EXACT [GOC:TermGenie] synonym: "downregulation of lipid localization" EXACT [GOC:TermGenie] synonym: "inhibition of lipid localisation" NARROW [GOC:TermGenie] synonym: "inhibition of lipid localization" NARROW [GOC:TermGenie] synonym: "negative regulation of lipid localisation" EXACT [GOC:TermGenie] is_a: GO:0048519 ! negative regulation of biological process is_a: GO:1905952 ! regulation of lipid localization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0010876 ! negatively regulates lipid localization relationship: RO:0002212 GO:0010876 ! negatively regulates lipid localization creation_date: 2017-02-21T12:12:41Z [Term] id: GO:1905954 name: positive regulation of lipid localization namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of lipid localization." [GO_REF:0000058, GOC:TermGenie, PMID:17564681] synonym: "activation of lipid localisation" NARROW [GOC:TermGenie] synonym: "activation of lipid localization" NARROW [GOC:TermGenie] synonym: "positive regulation of lipid localisation" EXACT [GOC:TermGenie] synonym: "up regulation of lipid localisation" EXACT [GOC:TermGenie] synonym: "up regulation of lipid localization" EXACT [GOC:TermGenie] synonym: "up-regulation of lipid localisation" EXACT [GOC:TermGenie] synonym: "up-regulation of lipid localization" EXACT [GOC:TermGenie] synonym: "upregulation of lipid localisation" EXACT [GOC:TermGenie] synonym: "upregulation of lipid localization" EXACT [GOC:TermGenie] is_a: GO:0048518 ! positive regulation of biological process is_a: GO:1905952 ! regulation of lipid localization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0010876 ! positively regulates lipid localization relationship: RO:0002213 GO:0010876 ! positively regulates lipid localization creation_date: 2017-02-21T12:12:49Z [Term] id: GO:1905955 name: negative regulation of endothelial tube morphogenesis namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of endothelial tube morphogenesis." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:25961718] synonym: "down regulation of endothelial tube morphogenesis" EXACT [GOC:TermGenie] synonym: "down-regulation of endothelial tube morphogenesis" EXACT [GOC:TermGenie] synonym: "downregulation of endothelial tube morphogenesis" EXACT [GOC:TermGenie] synonym: "inhibition of endothelial tube morphogenesis" NARROW [GOC:TermGenie] is_a: GO:0051241 ! negative regulation of multicellular organismal process is_a: GO:1901509 ! regulation of endothelial tube morphogenesis is_a: GO:1905331 ! negative regulation of morphogenesis of an epithelium intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0061154 ! negatively regulates endothelial tube morphogenesis relationship: RO:0002212 GO:0061154 ! negatively regulates endothelial tube morphogenesis creation_date: 2017-02-21T15:17:31Z [Term] id: GO:1905956 name: positive regulation of endothelial tube morphogenesis namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of endothelial tube morphogenesis." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:25961718] synonym: "activation of endothelial tube morphogenesis" NARROW [GOC:TermGenie] synonym: "up regulation of endothelial tube morphogenesis" EXACT [GOC:TermGenie] synonym: "up-regulation of endothelial tube morphogenesis" EXACT [GOC:TermGenie] synonym: "upregulation of endothelial tube morphogenesis" EXACT [GOC:TermGenie] is_a: GO:0051240 ! positive regulation of multicellular organismal process is_a: GO:1901509 ! regulation of endothelial tube morphogenesis is_a: GO:1905332 ! positive regulation of morphogenesis of an epithelium intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0061154 ! positively regulates endothelial tube morphogenesis relationship: RO:0002213 GO:0061154 ! positively regulates endothelial tube morphogenesis creation_date: 2017-02-21T15:17:39Z [Term] id: GO:1905957 name: regulation of cellular response to alcohol namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cellular response to alcohol." [GO_REF:0000058, GOC:TermGenie, PMID:26434723] is_a: GO:0050794 ! regulation of cellular process is_a: GO:1901419 ! regulation of response to alcohol intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0097306 ! regulates cellular response to alcohol relationship: RO:0002211 GO:0097306 ! regulates cellular response to alcohol creation_date: 2017-02-22T12:03:00Z [Term] id: GO:1905958 name: negative regulation of cellular response to alcohol namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of cellular response to alcohol." [GO_REF:0000058, GOC:TermGenie, PMID:26434723] synonym: "down regulation of cellular response to alcohol" EXACT [GOC:TermGenie] synonym: "down-regulation of cellular response to alcohol" EXACT [GOC:TermGenie] synonym: "downregulation of cellular response to alcohol" EXACT [GOC:TermGenie] synonym: "inhibition of cellular response to alcohol" NARROW [GOC:TermGenie] is_a: GO:0048523 ! negative regulation of cellular process is_a: GO:1901420 ! negative regulation of response to alcohol is_a: GO:1905957 ! regulation of cellular response to alcohol intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0097306 ! negatively regulates cellular response to alcohol relationship: RO:0002212 GO:0097306 ! negatively regulates cellular response to alcohol creation_date: 2017-02-22T12:03:08Z [Term] id: GO:1905959 name: positive regulation of cellular response to alcohol namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cellular response to alcohol." [GO_REF:0000058, GOC:TermGenie, PMID:26434723] synonym: "activation of cellular response to alcohol" NARROW [GOC:TermGenie] synonym: "up regulation of cellular response to alcohol" EXACT [GOC:TermGenie] synonym: "up-regulation of cellular response to alcohol" EXACT [GOC:TermGenie] synonym: "upregulation of cellular response to alcohol" EXACT [GOC:TermGenie] is_a: GO:0048522 ! positive regulation of cellular process is_a: GO:1901421 ! positive regulation of response to alcohol is_a: GO:1905957 ! regulation of cellular response to alcohol intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0097306 ! positively regulates cellular response to alcohol relationship: RO:0002213 GO:0097306 ! positively regulates cellular response to alcohol creation_date: 2017-02-22T12:03:16Z [Term] id: GO:1905962 name: glutamatergic neuron differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires the specialized features of a glutamatergic neuron." [GO_REF:0000086, GOC:TermGenie, PMID:24030726] is_a: GO:0030182 ! neuron differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000679 ! results in acquisition of features of glutamatergic neuron relationship: RO:0002315 CL:0000679 ! results in acquisition of features of glutamatergic neuron creation_date: 2017-02-23T17:40:43Z [Term] id: GO:1990009 name: retinal cell apoptotic process namespace: biological_process def: "Any apoptotic process in a retinal cell." [GOC:mtg_apoptosis, PMID:15558487, PMID:24664675] synonym: "induction of retinal programmed cell death" RELATED [] is_a: GO:0006915 ! apoptotic process intersection_of: GO:0006915 ! apoptotic process intersection_of: BFO:0000066 CL:0009004 ! occurs in retinal cell relationship: BFO:0000066 CL:0009004 ! occurs in retinal cell property_value: RO:0002161 NCBITaxon:4896 creation_date: 2012-12-12T10:15:08Z [Term] id: GO:1990010 name: compound eye retinal cell apoptotic process namespace: biological_process def: "Any apoptotic process in a compound eye retinal cell." [GOC:mtg_apoptosis, PMID:12021768] is_a: GO:1990009 ! retinal cell apoptotic process intersection_of: GO:0006915 ! apoptotic process intersection_of: BFO:0000066 CL:0009001 ! occurs in compound eye retinal cell relationship: BFO:0000066 CL:0009001 ! occurs in compound eye retinal cell property_value: RO:0002161 NCBITaxon:4896 creation_date: 2012-12-12T10:21:07Z [Term] id: GO:1990034 name: calcium ion export across plasma membrane namespace: biological_process def: "The directed movement of calcium ions from inside of a cell, across the plasma membrane and into the extracellular region." [GOC:mah, PMID:2145281] synonym: "calcium ion efflux from cell" EXACT [GOC:vw, PMID:2145281] synonym: "calcium ion export from cell" EXACT [] is_a: GO:0070588 ! calcium ion transmembrane transport is_a: GO:0140115 ! export across plasma membrane intersection_of: GO:0006810 ! transport intersection_of: RO:0002338 GO:0005829 ! has target start location cytosol intersection_of: RO:0002339 GO:0005576 ! has target end location extracellular region intersection_of: RO:0002342 GO:0005886 ! results in transport across plasma membrane intersection_of: RO:0004009 CHEBI:29108 ! has primary input creation_date: 2013-02-07T13:01:29Z [Term] id: GO:1990048 name: anterograde neuronal dense core vesicle transport namespace: biological_process def: "The directed movement of substances in neuronal dense core vesicles along axonal microtubules towards the presynapse." [GOC:kmv, PMID:23358451] subset: goslim_synapse synonym: "anterograde dense core granule trafficking" EXACT [] synonym: "anterograde dense core granule transport" EXACT [] is_a: GO:0008089 ! anterograde axonal transport is_a: GO:0047496 ! vesicle transport along microtubule is_a: GO:0099519 ! dense core granule cytoskeletal transport intersection_of: GO:0006810 ! transport intersection_of: BFO:0000066 GO:1904115 ! occurs in axon cytoplasm intersection_of: RO:0002339 GO:0098793 ! has target end location presynapse intersection_of: RO:0002341 GO:0005874 ! results in transport along microtubule intersection_of: RO:0004009 GO:0098992 ! has primary input neuronal dense core vesicle relationship: RO:0004009 GO:0098992 ! has primary input neuronal dense core vesicle [Term] id: GO:1990049 name: retrograde neuronal dense core vesicle transport namespace: biological_process def: "The directed movement of neuronal dense core vesicles along axonal microtubules towards the cell body." [GOC:kmv, PMID:23358451, PMID:24762653] subset: goslim_synapse synonym: "retrograde dense core granule trafficking" EXACT [] synonym: "retrograde dense core granule transport" EXACT [] is_a: GO:0008090 ! retrograde axonal transport is_a: GO:0047496 ! vesicle transport along microtubule is_a: GO:0099519 ! dense core granule cytoskeletal transport intersection_of: GO:0006810 ! transport intersection_of: BFO:0000066 GO:1904115 ! occurs in axon cytoplasm intersection_of: RO:0002338 GO:0098793 ! has target start location presynapse intersection_of: RO:0002341 GO:0005874 ! results in transport along microtubule intersection_of: RO:0004009 GO:0098992 ! has primary input neuronal dense core vesicle relationship: RO:0004009 GO:0098992 ! has primary input neuronal dense core vesicle creation_date: 2013-02-19T13:31:44Z [Term] id: GO:1990079 name: cartilage homeostasis namespace: biological_process def: "A tissue homeostatic process involved in the maintenance of an internal equilibrium within cartilage, including control of cellular proliferation and death and control of metabolic function." [GOC:hjd, PMID:21652695] synonym: "negative regulation of cartilage homeostasis" RELATED [] synonym: "positive regulation of cartilage homeostasis" RELATED [] synonym: "regulation of cartilage homeostasis" RELATED [] is_a: GO:0001894 ! tissue homeostasis property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 creation_date: 2013-04-29T20:10:15Z [Term] id: GO:1990086 name: lens fiber cell apoptotic process namespace: biological_process def: "Any apoptotic process in a lens fiber cell. Lens fiber cells are elongated, tightly packed cells that make up the bulk of the mature lens in a camera-type eye." [CL:0011004, GOC:hjd, PMID:11095619] is_a: GO:1904019 ! epithelial cell apoptotic process intersection_of: GO:0006915 ! apoptotic process intersection_of: BFO:0000066 CL:0011004 ! occurs in lens fiber cell relationship: BFO:0000066 CL:0011004 ! occurs in lens fiber cell property_value: RO:0002161 NCBITaxon:4751 creation_date: 2013-05-01T19:09:28Z [Term] id: GO:1990182 name: exosomal secretion namespace: biological_process def: "The process whereby a membrane-bounded vesicle is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane." [GOC:hjd, PMID:10572093, PMID:12154376, PMID:16773132, PMID:18617898] synonym: "exosomal protein secretion" NARROW [PMID:18617898] synonym: "exosomal secretory pathway" EXACT [PMID:18617898] synonym: "extracellular vesicular exosome secretion" EXACT [GOC:hjd] synonym: "multi-vesicular body fusion with plasma membrane" EXACT [] synonym: "secretion of exosome" EXACT [PMID:18617898] is_a: GO:0006887 ! exocytosis is_a: GO:0051650 ! establishment of vesicle localization intersection_of: GO:0006887 ! exocytosis intersection_of: RO:0004009 GO:0070062 ! has primary input extracellular exosome relationship: BFO:0000050 GO:0097734 ! part of extracellular exosome biogenesis relationship: RO:0004009 GO:0070062 ! has primary input extracellular exosome property_value: RO:0002161 NCBITaxon:4890 creation_date: 2013-09-04T21:08:14Z [Term] id: GO:1990188 name: euchromatin binding namespace: molecular_function def: "Binding to euchromatin, a dispersed and relatively uncompacted form of chromatin." [GOC:vw, PMID:22431512] is_a: GO:0003682 ! chromatin binding intersection_of: GO:0005488 ! binding intersection_of: RO:0004009 GO:0000791 ! has primary input euchromatin relationship: RO:0004009 GO:0000791 ! has primary input euchromatin creation_date: 2013-09-11T19:18:38Z [Term] id: GO:1990234 name: transferase complex namespace: cellular_component def: "A protein complex capable of catalyzing the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor)." [GOC:bhm, PMID:16540464] is_a: GO:1902494 ! catalytic complex intersection_of: GO:1902494 ! catalytic complex intersection_of: RO:0002215 GO:0016740 ! capable of transferase activity relationship: RO:0002215 GO:0016740 ! capable of transferase activity creation_date: 2013-11-12T13:20:12Z [Term] id: GO:1990239 name: steroid hormone binding namespace: molecular_function def: "Binding to a steroid hormone." [GOC:ln] is_a: GO:0005496 ! steroid binding is_a: GO:0042562 ! hormone binding intersection_of: GO:0005488 ! binding intersection_of: RO:0004009 CHEBI:26764 ! has primary input relationship: RO:0004009 CHEBI:26764 ! has primary input creation_date: 2013-11-15T09:26:18Z [Term] id: GO:1990254 name: keratin filament binding namespace: molecular_function def: "Binding to a keratin filament, an intermediate filament composed of acidic and basic keratins (types I and II), typically expressed in epithelial cells." [GOC:krc, PMID:6170061] is_a: GO:0019215 ! intermediate filament binding intersection_of: GO:0005488 ! binding intersection_of: RO:0004009 GO:0045095 ! has primary input keratin filament relationship: RO:0004009 GO:0045095 ! has primary input keratin filament creation_date: 2013-12-13T22:05:25Z [Term] id: GO:1990266 name: neutrophil migration namespace: biological_process def: "The movement of a neutrophil within or between different tissues and organs of the body." [PMID:1826836] is_a: GO:0097530 ! granulocyte migration intersection_of: GO:0016477 ! cell migration intersection_of: RO:0002565 CL:0000775 ! results in movement of neutrophil relationship: RO:0002565 CL:0000775 ! results in movement of neutrophil creation_date: 2014-01-10T00:17:47Z [Term] id: GO:1990280 name: RNA localization to chromatin namespace: biological_process def: "A process in which RNA is transported to and maintained in a part of a chromosome that is organized into chromatin." [GOC:dos, GOC:mah, PMID:22582262] synonym: "RNA localisation to chromatin" EXACT [] is_a: GO:0006403 ! RNA localization intersection_of: GO:0006403 ! RNA localization intersection_of: RO:0002339 GO:0000785 ! has target end location chromatin relationship: RO:0002339 GO:0000785 ! has target end location chromatin creation_date: 2014-01-30T15:55:34Z [Term] id: GO:1990351 name: transporter complex namespace: cellular_component def: "A protein complex facilitating transport of molecules (proteins, small molecules, nucleic acids) into, out of or within a cell, or between cells." [GOC:bhm, PMID:15449578] comment: An example of this is GTR1 in human (UniProt symbol P11166) in PMID:15449578 (inferred from direct assay). is_a: BFO:0000004 is_a: GO:0032991 ! protein-containing complex intersection_of: GO:0032991 ! protein-containing complex intersection_of: RO:0002215 GO:0005215 ! capable of transporter activity relationship: RO:0002215 GO:0005215 ! capable of transporter activity creation_date: 2014-03-26T14:23:27Z [Term] id: GO:1990375 name: baculum development namespace: biological_process def: "The reproductive developmental process whose specific outcome is the progression of the baculum over time, from its formation to the mature structure." [GOC:sl, PMID:21471296] synonym: "os penis development" EXACT [GOC:sl] synonym: "penile bone development" EXACT [GOC:sl] synonym: "penis bone development" EXACT [GOC:sl] is_a: GO:0048608 ! reproductive structure development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0006435 ! results in development of os penis relationship: RO:0002296 UBERON:0006435 ! results in development of os penis creation_date: 2014-05-01T23:59:13Z [Term] id: GO:1990379 name: lipid transport across blood-brain barrier namespace: biological_process def: "The directed movement of lipid molecules passing through the blood-brain barrier." [GOC:sjp, PMID:24345162] synonym: "lipid transport across blood brain barrier" EXACT [] is_a: GO:0006869 ! lipid transport is_a: GO:0150104 ! transport across blood-brain barrier intersection_of: GO:0150104 ! transport across blood-brain barrier intersection_of: RO:0002342 UBERON:0000120 ! results in transport across blood brain barrier intersection_of: RO:0004009 CHEBI:18059 ! has primary input creation_date: 2014-05-08T09:52:28Z [Term] id: GO:1990461 name: detoxification of iron ion namespace: biological_process def: "Any process that reduces or removes the toxicity of iron ion. These include transport of iron away from sensitive areas and to compartments or complexes whose purpose is sequestration of iron ion." [GOC:sart, PMID:23064556] is_a: GO:0061687 ! detoxification of inorganic compound intersection_of: GO:0098754 ! detoxification intersection_of: RO:0004009 CHEBI:24875 ! has primary input relationship: BFO:0000050 GO:0010039 ! part of response to iron ion relationship: RO:0004009 CHEBI:24875 ! has primary input creation_date: 2014-08-19T10:12:46Z [Term] id: GO:1990497 name: regulation of cytoplasmic translation in response to stress namespace: biological_process def: "Modulation of the frequency, rate or extent of cytoplasmic translation as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:vw, PMID:16278445] is_a: GO:0043555 ! regulation of translation in response to stress is_a: GO:2000765 ! regulation of cytoplasmic translation intersection_of: GO:0065007 ! biological regulation intersection_of: BFO:0000050 GO:0033554 ! part of cellular response to stress intersection_of: RO:0002211 GO:0002181 ! regulates cytoplasmic translation creation_date: 2014-09-26T11:11:29Z [Term] id: GO:1990502 name: dense core granule maturation namespace: biological_process def: "Steps required to transform a dense core granule generated at the trans-Golgi network into a fully formed and transmissible dense core granule. Dense core granule maturation proceeds through clathrin-mediated membrane remodeling events and is essential for efficient processing of cargo within dense core granules as well as for removing factors that might otherwise interfere with dense core granule trafficking and exocytosis." [GOC:kmv, PMID:22654674] synonym: "dense core vesicle maturation" EXACT [] is_a: GO:0061792 ! secretory granule maturation intersection_of: GO:0021700 ! developmental maturation intersection_of: RO:0002299 GO:0031045 ! results in maturation of dense core granule relationship: RO:0002299 GO:0031045 ! results in maturation of dense core granule property_value: RO:0002161 NCBITaxon:4890 creation_date: 2014-09-30T20:35:11Z [Term] id: GO:1990504 name: dense core granule exocytosis namespace: biological_process def: "The secretion of molecules (e.g. neuropeptides, insulin-related peptides or neuromodulators such as serotonin and dopamine) contained within a membrane-bounced dense core granule by fusion of the granule with the plasma membrane of a cell in response to increased cytosolic calcium levels." [GOC:kmv, PMID:17553987, PMID:24653208] synonym: "dense core vesicle exocytosis" EXACT [] is_a: GO:0017156 ! calcium-ion regulated exocytosis is_a: GO:0032253 ! dense core granule localization is_a: GO:0051650 ! establishment of vesicle localization intersection_of: GO:0045055 ! regulated exocytosis intersection_of: RO:0002334 GO:0007204 ! regulated by positive regulation of cytosolic calcium ion concentration intersection_of: RO:0004009 GO:0031045 ! has primary input dense core granule creation_date: 2014-09-30T21:05:50Z [Term] id: GO:1990542 name: mitochondrial transmembrane transport namespace: biological_process def: "The process in which a solute is transported from one side of a membrane to the other into, out of or within a mitochondrion." [PMID:20533899] is_a: GO:0006839 ! mitochondrial transport is_a: GO:0055085 ! transmembrane transport intersection_of: GO:0046907 ! intracellular transport intersection_of: RO:0002342 GO:0031966 ! results in transport across mitochondrial membrane relationship: RO:0002342 GO:0031966 ! results in transport across mitochondrial membrane property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/24829" xsd:anyURI property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/25275" xsd:anyURI property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/26201" xsd:anyURI property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/29962" xsd:anyURI creation_date: 2014-11-19T11:19:21Z [Term] id: GO:1990544 name: mitochondrial ATP transmembrane transport namespace: biological_process def: "The process in which ATP is transported across a mitochondrial membrane, into or out of the mitochondrion." [PMID:18485069] is_a: GO:0015867 ! ATP transport is_a: GO:0072530 ! purine-containing compound transmembrane transport is_a: GO:1901679 ! nucleotide transmembrane transport intersection_of: GO:0006810 ! transport intersection_of: RO:0002342 GO:0031966 ! results in transport across mitochondrial membrane intersection_of: RO:0004009 CHEBI:30616 ! has primary input relationship: RO:0002342 GO:0031966 ! results in transport across mitochondrial membrane creation_date: 2014-11-19T11:43:33Z [Term] id: GO:1990547 name: mitochondrial phosphate ion transmembrane transport namespace: biological_process def: "The process in which a phosphate ion is transported across a mitochondrial membrane, into or out of the mitochondrion." [PMID:9099701] is_a: GO:0035435 ! phosphate ion transmembrane transport intersection_of: GO:0006810 ! transport intersection_of: RO:0002342 GO:0031966 ! results in transport across mitochondrial membrane intersection_of: RO:0004009 CHEBI:43474 ! has primary input relationship: RO:0002342 GO:0031966 ! results in transport across mitochondrial membrane creation_date: 2014-11-19T11:50:19Z [Term] id: GO:1990573 name: potassium ion import across plasma membrane namespace: biological_process def: "The directed movement of potassium ions from outside of a cell, across the plasma membrane and into the cytosol." [PMID:9139127] synonym: "potassium import" BROAD [] synonym: "potassium ion import" BROAD [] synonym: "potassium ion uptake" BROAD [GOC:dph, GOC:tb] is_a: GO:0071805 ! potassium ion transmembrane transport is_a: GO:0098659 ! inorganic cation import across plasma membrane intersection_of: GO:0006810 ! transport intersection_of: RO:0002338 GO:0005576 ! has target start location extracellular region intersection_of: RO:0002339 GO:0005829 ! has target end location cytosol intersection_of: RO:0002342 GO:0005886 ! results in transport across plasma membrane intersection_of: RO:0004009 CHEBI:29103 ! has primary input creation_date: 2014-12-04T09:48:12Z [Term] id: GO:1990580 name: regulation of cytoplasmic translational termination namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cytoplasmic translational termination." [PMID:11570975] is_a: GO:0006449 ! regulation of translational termination is_a: GO:2000765 ! regulation of cytoplasmic translation intersection_of: GO:0050789 ! regulation of biological process intersection_of: RO:0002211 GO:0002184 ! regulates cytoplasmic translational termination relationship: RO:0002211 GO:0002184 ! regulates cytoplasmic translational termination creation_date: 2014-12-10T15:48:55Z [Term] id: GO:1990611 name: regulation of cytoplasmic translational initiation in response to stress namespace: biological_process def: "Modulation of the frequency, rate or extent of cytoplasmic translational initiation as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [PMID:16278445] is_a: GO:0043558 ! regulation of translational initiation in response to stress is_a: GO:1904688 ! regulation of cytoplasmic translational initiation is_a: GO:1990497 ! regulation of cytoplasmic translation in response to stress intersection_of: GO:0065007 ! biological regulation intersection_of: BFO:0000050 GO:0033554 ! part of cellular response to stress intersection_of: RO:0002211 GO:0002183 ! regulates cytoplasmic translational initiation creation_date: 2015-01-20T13:04:14Z [Term] id: GO:1990625 name: negative regulation of cytoplasmic translational initiation in response to stress namespace: biological_process def: "Any process that stops, prevents or reduces the rate of cytoplasmic translation initiation as a result of a stimulus indicating the organism is under stress." [GOC:vw, PMID:12242291] is_a: GO:0032055 ! negative regulation of translation in response to stress is_a: GO:0032057 ! negative regulation of translational initiation in response to stress is_a: GO:1904689 ! negative regulation of cytoplasmic translational initiation is_a: GO:1990611 ! regulation of cytoplasmic translational initiation in response to stress intersection_of: GO:0065007 ! biological regulation intersection_of: BFO:0000050 GO:0033554 ! part of cellular response to stress intersection_of: RO:0002212 GO:0002183 ! negatively regulates cytoplasmic translational initiation creation_date: 2015-01-31T21:25:56Z [Term] id: GO:1990654 name: sebum secreting cell proliferation namespace: biological_process def: "The multiplication or reproduction of sebocytes by cell division, resulting in the expansion of their population. A sebocyte is an epithelial cell that makes up the sebaceous glands, and secrete sebum." [GOC:hjd, PMID:16901790, PMID:18474083] synonym: "sebocyte proliferation" RELATED [GOC:dph] is_a: GO:0050673 ! epithelial cell proliferation intersection_of: GO:0008283 ! cell population proliferation intersection_of: RO:0012003 CL:0000317 ! acts on population of sebocyte relationship: RO:0012003 CL:0000317 ! acts on population of sebocyte property_value: RO:0002161 NCBITaxon:4751 creation_date: 2015-02-23T19:43:49Z [Term] id: GO:1990705 name: cholangiocyte proliferation namespace: biological_process def: "The multiplication or reproduction of cholangiocytes, resulting in the expansion of the cholangiocyte population. A cholangiocyte is an epithelial cell that is part of the bile duct. Cholangiocytes contribute to bile secretion via net release of bicarbonate and water." [PMID:24434010] synonym: "hepatoblast proliferation" EXACT [] is_a: GO:0050673 ! epithelial cell proliferation intersection_of: GO:0008283 ! cell population proliferation intersection_of: RO:0012003 CL:1000488 ! acts on population of cholangiocyte relationship: RO:0012003 CL:1000488 ! acts on population of cholangiocyte property_value: RO:0002161 NCBITaxon:4751 creation_date: 2015-03-16T23:23:50Z [Term] id: GO:1990716 name: axonemal central apparatus namespace: cellular_component def: "Part of the 9+2 axoneme, that occurs in most motile cilia, consisting of the pair of two single central microtubules and their associated structures which include the central pair projections, the central pair bridges linking the two tubules, and the central pair caps which are attached to the distal or plus ends of the microtubules." [GOC:cilia, PMID:21586547, PMID:9295136] is_a: GO:0110165 ! cellular anatomical structure relationship: BFO:0000050 GO:0005930 ! part of axoneme property_value: RO:0002161 NCBITaxon:3176 property_value: RO:0002161 NCBITaxon:3378 property_value: RO:0002161 NCBITaxon:3398 property_value: RO:0002161 NCBITaxon:4890 property_value: RO:0002161 NCBITaxon:5782 creation_date: 2015-03-27T22:33:23Z [Term] id: GO:1990719 name: C1 axonemal microtubule namespace: cellular_component def: "One of two microtubules present in the axonemal central pair. It is distinguishable from the C2 axonemal microtubule (also called C2 tubule) by the presence of differing protein components of the projections." [GOC:cilia, PMID:21586547, PMID:9295136] synonym: "C1 tubule" BROAD [] is_a: GO:0005879 ! axonemal microtubule relationship: BFO:0000050 GO:0097540 ! part of axonemal central pair property_value: RO:0002161 NCBITaxon:3176 property_value: RO:0002161 NCBITaxon:3378 property_value: RO:0002161 NCBITaxon:3398 property_value: RO:0002161 NCBITaxon:4890 property_value: RO:0002161 NCBITaxon:5782 creation_date: 2015-03-27T22:55:12Z [Term] id: GO:1990720 name: C2 axonemal microtubule namespace: cellular_component def: "One of two microtubules present in the axonemal central pair. It is distinguishable from the C1 axonemal microtubule (also called C1 tubule) by the presence of differing protein components of the projections." [GOC:cilia, PMID:21586547, PMID:9295136] synonym: "C2 tubule" BROAD [] is_a: GO:0005879 ! axonemal microtubule relationship: BFO:0000050 GO:0097540 ! part of axonemal central pair property_value: RO:0002161 NCBITaxon:3176 property_value: RO:0002161 NCBITaxon:3378 property_value: RO:0002161 NCBITaxon:3398 property_value: RO:0002161 NCBITaxon:4890 property_value: RO:0002161 NCBITaxon:5782 creation_date: 2015-03-27T22:58:40Z [Term] id: GO:1990739 name: granulosa cell proliferation namespace: biological_process def: "The multiplication or reproduction of granulosa cells, resulting in the expansion of the granulosa cells population. A granulosa cell is a supporting cell for the developing female gamete in the ovary of mammals. They develop from the coelomic epithelial cells of the gonadal ridge." [PMID:22383759] is_a: GO:0050673 ! epithelial cell proliferation intersection_of: GO:0008283 ! cell population proliferation intersection_of: RO:0012003 CL:0000501 ! acts on population of granulosa cell relationship: RO:0012003 CL:0000501 ! acts on population of granulosa cell property_value: RO:0002161 NCBITaxon:4751 creation_date: 2015-05-06T18:56:04Z [Term] id: GO:1990748 name: cellular detoxification namespace: biological_process def: "Any process carried out at the cellular level that reduces or removes the toxicity of a toxic substance. These may include transport of the toxic substance away from sensitive areas and to compartments or complexes whose purpose is sequestration of the toxic substance." [GOC:vw] is_a: BFO:0000003 is_a: GO:0009987 ! cellular process is_a: GO:0098754 ! detoxification intersection_of: GO:0098754 ! detoxification intersection_of: BFO:0000066 CL:0000000 ! occurs in cell relationship: BFO:0000050 GO:0097237 ! part of cellular response to toxic substance relationship: BFO:0000066 CL:0000000 ! occurs in cell creation_date: 2015-05-18T16:17:46Z [Term] id: GO:1990751 name: Schwann cell chemotaxis namespace: biological_process def: "The directed movement of a Schwann cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis)." [PMID:16203995] is_a: GO:0036135 ! Schwann cell migration is_a: GO:0060326 ! cell chemotaxis intersection_of: GO:0006935 ! chemotaxis intersection_of: RO:0002565 CL:0002573 ! results in movement of Schwann cell creation_date: 2015-05-21T19:19:09Z [Term] id: GO:1990765 name: colon smooth muscle contraction namespace: biological_process def: "A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry of the large intestine, exclusive of the rectum. The colon is that part of the large intestine that connects the small intestine to the rectum." [PMID:24170253] is_a: GO:0006939 ! smooth muscle contraction intersection_of: GO:0006939 ! smooth muscle contraction intersection_of: BFO:0000066 UBERON:0001155 ! occurs in colon relationship: BFO:0000050 GO:0014827 ! part of intestine smooth muscle contraction relationship: BFO:0000066 UBERON:0001155 ! occurs in colon relationship: RO:0002162 NCBITaxon:7742 ! in taxon Vertebrata creation_date: 2015-06-10T18:29:21Z [Term] id: GO:1990768 name: gastric mucosal blood circulation namespace: biological_process def: "The flow of blood through the gastric mucosa of an animal, enabling the transport of nutrients and the removal of waste products." [PMID:10807413] synonym: "stomach mucosal blood circulation" EXACT [] is_a: BFO:0000003 is_a: GO:0008015 ! blood circulation intersection_of: GO:0008015 ! blood circulation intersection_of: BFO:0000066 UBERON:0004786 ! occurs in gastrointestinal system mucosa relationship: BFO:0000066 UBERON:0004786 ! occurs in gastrointestinal system mucosa property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 creation_date: 2015-06-10T20:11:09Z [Term] id: GO:1990770 name: small intestine smooth muscle contraction namespace: biological_process def: "A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry in the intestine between the stomach and the large intestine." [PMID:11991626] is_a: GO:0006939 ! smooth muscle contraction intersection_of: GO:0006939 ! smooth muscle contraction intersection_of: BFO:0000066 UBERON:0002108 ! occurs in small intestine relationship: BFO:0000050 GO:0014827 ! part of intestine smooth muscle contraction relationship: BFO:0000066 UBERON:0002108 ! occurs in small intestine relationship: RO:0002162 NCBITaxon:7742 ! in taxon Vertebrata creation_date: 2015-06-11T18:02:33Z [Term] id: GO:1990777 name: lipoprotein particle namespace: cellular_component def: "A spherical particle containing non-covalently associated proteins and lipids. Examples are plasma lipoprotein particles which transport lipids in the blood or lymph." [GOC:vesicles] is_a: GO:0032994 ! protein-lipid complex creation_date: 2015-06-18T08:42:53Z [Term] id: GO:1990778 name: protein localization to cell periphery namespace: biological_process def: "A process in which a protein is transported to, or maintained in, the cell periphery." [PMID:18216290] is_a: GO:0008104 ! intracellular protein localization intersection_of: GO:0008104 ! intracellular protein localization intersection_of: RO:0002339 GO:0071944 ! has target end location cell periphery relationship: RO:0002339 GO:0071944 ! has target end location cell periphery creation_date: 2015-06-18T22:37:39Z [Term] id: GO:1990791 name: dorsal root ganglion development namespace: biological_process def: "The process whose specific outcome is the progression of a dorsal root ganglion over time, from its formation to the mature structure." [PMID:18583150] synonym: "DRG development" EXACT [] is_a: GO:0061548 ! ganglion development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0000044 ! results in development of dorsal root ganglion relationship: RO:0002162 NCBITaxon:89593 ! in taxon Craniata relationship: RO:0002296 UBERON:0000044 ! results in development of dorsal root ganglion creation_date: 2015-07-02T22:09:54Z [Term] id: GO:1990806 name: ligand-gated ion channel signaling pathway namespace: biological_process def: "The series of molecular signals initiated by activation of a ligand-gated ion channel on the surface of a cell. The pathway begins with binding of an extracellular ligand to a ligand-gated ion channel and ends with a molecular function that directly regulates a downstream cellular process, e.g. transcription." [GOC:bhm, PMID:25869137] synonym: "ligand-gated ion channel signalling pathway" EXACT [] is_a: GO:0007165 ! signal transduction intersection_of: GO:0007165 ! signal transduction intersection_of: BFO:0000051 GO:0015276 ! has part ligand-gated monoatomic ion channel activity relationship: BFO:0000051 GO:0015276 ! has part ligand-gated monoatomic ion channel activity creation_date: 2015-07-20T12:09:56Z [Term] id: GO:1990822 name: basic amino acid transmembrane transport namespace: biological_process def: "The directed movement of basic amino acids from one side of a membrane to the other." [GOC:dph, GOC:vw] is_a: GO:0003333 ! amino acid transmembrane transport is_a: GO:0015802 ! basic amino acid transport intersection_of: GO:0015802 ! basic amino acid transport intersection_of: RO:0002342 GO:0016020 ! results in transport across membrane creation_date: 2015-08-19T07:47:00Z [Term] id: GO:1990845 name: adaptive thermogenesis namespace: biological_process def: "The regulated production of heat in response to short term environmental changes, such as stress, diet or reduced temperature." [PMID:17260010, PMID:20363363] xref: Reactome:R-HSA-166187 "Mitochondrial Uncoupling" is_a: GO:0008152 ! metabolic process creation_date: 2015-08-31T18:19:49Z [Term] id: GO:1990849 name: vacuolar localization namespace: biological_process def: "Any process in which the vacuole is transported to, and/or maintained in, a specific location within the cell." [PMID:26283797] synonym: "maintenance of vacuolar localization" EXACT [] synonym: "maintenance of vacuolar location" NARROW [] synonym: "maintenance of vacuole localization" EXACT [] synonym: "maintenance of vacuole location" EXACT [] is_a: GO:0051640 ! organelle localization intersection_of: GO:0051179 ! localization intersection_of: RO:0004009 GO:0005773 ! has primary input vacuole relationship: RO:0004009 GO:0005773 ! has primary input vacuole property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/22182" xsd:anyURI creation_date: 2015-09-10T08:16:02Z [Term] id: GO:1990863 name: acinar cell proliferation namespace: biological_process def: "The multiplication or reproduction of acinar cells, resulting in the expansion of a cell population. An acinar cell is a secretory cell that is grouped together with other cells of the same type to form grape-shaped clusters known as acini (singular acinus)." [PMID:9788538] synonym: "acinic cell proliferation" EXACT [] synonym: "acinous cell proliferation" EXACT [] is_a: GO:0050673 ! epithelial cell proliferation intersection_of: GO:0008283 ! cell population proliferation intersection_of: RO:0012003 CL:0000622 ! acts on population of acinar cell relationship: RO:0012003 CL:0000622 ! acts on population of acinar cell property_value: RO:0002161 NCBITaxon:4751 creation_date: 2015-09-25T14:26:09Z [Term] id: GO:1990874 name: vascular associated smooth muscle cell proliferation namespace: biological_process def: "The multiplication or reproduction of vascular smooth muscle cells, resulting in the expansion of a cell population. A vascular smooth muscle cell is a non-striated, elongated, spindle-shaped cell found lining the blood vessels." [PMID:23246467] synonym: "vascular smooth muscle cell proliferation" EXACT [] synonym: "VSMC proliferation" EXACT [] is_a: GO:0048659 ! smooth muscle cell proliferation intersection_of: GO:0008283 ! cell population proliferation intersection_of: RO:0012003 CL:0000359 ! acts on population of vascular associated smooth muscle cell relationship: RO:0012003 CL:0000359 ! acts on population of vascular associated smooth muscle cell property_value: RO:0002161 NCBITaxon:4751 creation_date: 2015-09-29T16:34:59Z [Term] id: GO:1990904 name: ribonucleoprotein complex namespace: cellular_component def: "A macromolecular complex that contains both RNA and protein molecules." [GOC:krc, GOC:vesicles] subset: goslim_pir synonym: "extracellular ribonucleoprotein complex" NARROW [] synonym: "intracellular ribonucleoprotein complex" NARROW [] synonym: "protein-RNA complex" EXACT [] synonym: "RNA-protein complex" EXACT [] synonym: "RNP" EXACT [] xref: Wikipedia:Ribonucleoprotein is_a: GO:0032991 ! protein-containing complex relationship: BFO:0000051 CHEBI:33697 ! has part creation_date: 2015-11-19T12:26:37Z [Term] id: GO:1990917 name: ooplasm namespace: cellular_component def: "The cytoplasm of an ovum." [PMID:19022436] is_a: GO:0005737 ! cytoplasm intersection_of: GO:0005737 ! cytoplasm intersection_of: BFO:0000050 CL:0000025 ! part of egg cell relationship: BFO:0000050 CL:0000025 ! part of egg cell creation_date: 2015-12-10T21:40:16Z [Term] id: GO:1990922 name: hepatic stellate cell proliferation namespace: biological_process def: "The multiplication or reproduction of hepatic stellate cells, resulting in the expansion of a hepatic stellate cell population. Hepatic stellate cells are found in the perisinusoidal space of the liver, and are capable of multiple roles including storage of retinol, presentation of antigen to T cells (including CD1d-restricted NKT cells), and upon activation, production of extracellular matrix components. This cell type comprises approximately 8-15% of total cells in the liver." [GOC:sl, PMID:15358192, PMID:18466260] synonym: "hepatic perisinusoidal cell proliferation" EXACT [] synonym: "Ito cell proliferation" EXACT [] synonym: "perisinusoidal cell proliferation" EXACT [] is_a: GO:0048144 ! fibroblast proliferation intersection_of: GO:0008283 ! cell population proliferation intersection_of: RO:0012003 CL:0000632 ! acts on population of hepatic stellate cell relationship: RO:0012003 CL:0000632 ! acts on population of hepatic stellate cell property_value: RO:0002161 NCBITaxon:4751 creation_date: 2016-01-13T23:12:57Z [Term] id: GO:1990959 name: eosinophil homeostasis namespace: biological_process def: "The process of regulating the proliferation and elimination of eosinophils such that the total number of eosinophils within a whole or part of an organism is stable over time in the absence of an outside stimulus." [PMID:10606160] synonym: "eosinocyte homeostasis" EXACT [] synonym: "eosinophilic granulocyte homeostasis" EXACT [] synonym: "eosinophilic leucocyte homeostasis" EXACT [] synonym: "eosinophilic leukocyte homeostasis" EXACT [] is_a: GO:0001776 ! leukocyte homeostasis is_a: GO:0002262 ! myeloid cell homeostasis intersection_of: GO:0048872 ! homeostasis of number of cells intersection_of: RO:0012003 CL:0000771 ! acts on population of eosinophil relationship: RO:0012003 CL:0000771 ! acts on population of eosinophil creation_date: 2016-06-06T22:34:31Z [Term] id: GO:1990960 name: basophil homeostasis namespace: biological_process def: "The process of regulating the proliferation and elimination of basophils such that the total number of basophils within a whole or part of an organism is stable over time in the absence of an outside stimulus." [PMID:10606160] synonym: "basophilic leucocyte homeostasis" EXACT [] is_a: GO:0001776 ! leukocyte homeostasis is_a: GO:0002262 ! myeloid cell homeostasis intersection_of: GO:0048872 ! homeostasis of number of cells intersection_of: RO:0012003 CL:0000767 ! acts on population of basophil relationship: RO:0012003 CL:0000767 ! acts on population of basophil creation_date: 2016-06-06T22:38:22Z [Term] id: GO:2000004 name: regulation of metanephric S-shaped body morphogenesis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of metanephric S-shaped body morphogenesis." [GOC:mtg_kidney_jan10, GOC:obol, GOC:yaf] is_a: GO:2000027 ! regulation of animal organ morphogenesis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0072284 ! regulates metanephric S-shaped body morphogenesis relationship: RO:0002211 GO:0072284 ! regulates metanephric S-shaped body morphogenesis creation_date: 2010-07-30T02:14:33Z [Term] id: GO:2000005 name: negative regulation of metanephric S-shaped body morphogenesis namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of metanephric S-shaped body morphogenesis." [GOC:mtg_kidney_jan10, GOC:obol, GOC:yaf] is_a: GO:0051093 ! negative regulation of developmental process is_a: GO:2000004 ! regulation of metanephric S-shaped body morphogenesis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0072284 ! negatively regulates metanephric S-shaped body morphogenesis relationship: RO:0002212 GO:0072284 ! negatively regulates metanephric S-shaped body morphogenesis creation_date: 2010-07-30T02:14:37Z [Term] id: GO:2000006 name: regulation of metanephric comma-shaped body morphogenesis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of metanephric comma-shaped body morphogenesis." [GOC:mtg_kidney_jan10, GOC:obol, GOC:yaf] is_a: GO:2000027 ! regulation of animal organ morphogenesis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0072278 ! regulates metanephric comma-shaped body morphogenesis relationship: RO:0002211 GO:0072278 ! regulates metanephric comma-shaped body morphogenesis creation_date: 2010-07-30T02:17:12Z [Term] id: GO:2000007 name: negative regulation of metanephric comma-shaped body morphogenesis namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of metanephric comma-shaped body morphogenesis." [GOC:mtg_kidney_jan10, GOC:obol, GOC:yaf] is_a: GO:0051093 ! negative regulation of developmental process is_a: GO:2000006 ! regulation of metanephric comma-shaped body morphogenesis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0072278 ! negatively regulates metanephric comma-shaped body morphogenesis relationship: RO:0002212 GO:0072278 ! negatively regulates metanephric comma-shaped body morphogenesis creation_date: 2010-07-30T02:17:17Z [Term] id: GO:2000018 name: regulation of male gonad development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of male gonad development." [GOC:obol, GOC:yaf] synonym: "regulation of testicular development" EXACT [GOC:obol] synonym: "regulation of testis development" EXACT [GOC:obol] is_a: GO:1905939 ! regulation of gonad development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0008584 ! regulates male gonad development relationship: RO:0002211 GO:0008584 ! regulates male gonad development property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 creation_date: 2010-07-15T03:29:05Z [Term] id: GO:2000019 name: negative regulation of male gonad development namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of male gonad development." [GOC:obol, GOC:yaf] synonym: "negative regulation of testicular development" EXACT [GOC:obol] synonym: "negative regulation of testis development" EXACT [GOC:obol] is_a: GO:1905940 ! negative regulation of gonad development is_a: GO:2000018 ! regulation of male gonad development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0008584 ! negatively regulates male gonad development relationship: RO:0002212 GO:0008584 ! negatively regulates male gonad development property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 creation_date: 2010-07-15T03:29:10Z [Term] id: GO:2000020 name: positive regulation of male gonad development namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of male gonad development." [GOC:obol] synonym: "positive regulation of testicular development" EXACT [GOC:obol] synonym: "positive regulation of testis development" EXACT [GOC:obol] is_a: GO:1905941 ! positive regulation of gonad development is_a: GO:2000018 ! regulation of male gonad development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0008584 ! positively regulates male gonad development relationship: RO:0002213 GO:0008584 ! positively regulates male gonad development property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 creation_date: 2010-07-15T03:29:13Z [Term] id: GO:2000026 name: regulation of multicellular organismal development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of multicellular organismal development." [GOC:obol] is_a: GO:0050793 ! regulation of developmental process is_a: GO:0051239 ! regulation of multicellular organismal process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0007275 ! regulates multicellular organism development relationship: RO:0002211 GO:0007275 ! regulates multicellular organism development property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 creation_date: 2010-08-05T11:25:59Z [Term] id: GO:2000027 name: regulation of animal organ morphogenesis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of animal organ morphogenesis." [GOC:obol] synonym: "regulation of histogenesis and organogenesis" RELATED [GOC:obol] is_a: GO:0022603 ! regulation of anatomical structure morphogenesis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0009887 ! regulates animal organ morphogenesis relationship: RO:0002211 GO:0009887 ! regulates animal organ morphogenesis creation_date: 2010-08-05T11:26:27Z [Term] id: GO:2000035 name: regulation of stem cell division namespace: biological_process def: "Any process that modulates the frequency, rate or extent of stem cell division." [GOC:obol] synonym: "regulation of stem cell renewal" EXACT [GOC:obol] is_a: GO:0051302 ! regulation of cell division intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0017145 ! regulates stem cell division relationship: RO:0002211 GO:0017145 ! regulates stem cell division property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4751 creation_date: 2010-08-05T11:34:53Z [Term] id: GO:2000036 name: regulation of stem cell population maintenance namespace: biological_process def: "Any process that modulates the frequency, rate or extent of stem cell population maintenance." [GOC:obol] synonym: "regulation of maintenance of pluripotency" RELATED [GOC:obol] is_a: GO:0050793 ! regulation of developmental process is_a: GO:0051239 ! regulation of multicellular organismal process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0019827 ! regulates stem cell population maintenance relationship: RO:0002211 GO:0019827 ! regulates stem cell population maintenance property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4751 creation_date: 2010-08-05T11:35:25Z [Term] id: GO:2000061 name: regulation of ureter smooth muscle cell differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of ureter smooth muscle cell differentiation." [GOC:mtg_kidney_jan10, GOC:obol, GOC:yaf] is_a: GO:0048634 ! regulation of muscle organ development is_a: GO:0051150 ! regulation of smooth muscle cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0072193 ! regulates ureter smooth muscle cell differentiation relationship: RO:0002211 GO:0072193 ! regulates ureter smooth muscle cell differentiation creation_date: 2010-08-20T01:44:16Z [Term] id: GO:2000062 name: negative regulation of ureter smooth muscle cell differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of ureter smooth muscle cell differentiation." [GOC:mtg_kidney_jan10, GOC:obol, GOC:yaf] is_a: GO:0051151 ! negative regulation of smooth muscle cell differentiation is_a: GO:0051241 ! negative regulation of multicellular organismal process is_a: GO:2000061 ! regulation of ureter smooth muscle cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0072193 ! negatively regulates ureter smooth muscle cell differentiation relationship: RO:0002212 GO:0072193 ! negatively regulates ureter smooth muscle cell differentiation creation_date: 2010-08-20T01:44:23Z [Term] id: GO:2000063 name: positive regulation of ureter smooth muscle cell differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of ureter smooth muscle cell differentiation." [GOC:mtg_kidney_jan10, GOC:obol, GOC:yaf] is_a: GO:0051152 ! positive regulation of smooth muscle cell differentiation is_a: GO:0051240 ! positive regulation of multicellular organismal process is_a: GO:2000061 ! regulation of ureter smooth muscle cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0072193 ! positively regulates ureter smooth muscle cell differentiation relationship: RO:0002213 GO:0072193 ! positively regulates ureter smooth muscle cell differentiation creation_date: 2010-08-20T01:44:28Z [Term] id: GO:2000068 name: regulation of defense response to insect namespace: biological_process def: "Any process that modulates the frequency, rate or extent of defense response to insect." [GOC:obol] synonym: "regulation of physiological defense response to insect" EXACT [GOC:obol] is_a: GO:0002831 ! regulation of response to biotic stimulus is_a: GO:0031347 ! regulation of defense response is_a: GO:0032101 ! regulation of response to external stimulus intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0002213 ! regulates defense response to insect relationship: RO:0002211 GO:0002213 ! regulates defense response to insect property_value: RO:0002161 NCBITaxon:4895 creation_date: 2010-08-23T09:30:00Z [Term] id: GO:2000070 name: regulation of response to water deprivation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of response to water deprivation." [GOC:obol] synonym: "regulation of drought tolerance" RELATED [GOC:obol] synonym: "regulation of response to dehydration" EXACT [GOC:obol] synonym: "regulation of response to drought" EXACT [GOC:obol] synonym: "regulation of response to thirst" EXACT [GOC:obol] is_a: GO:0080134 ! regulation of response to stress intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0009414 ! regulates response to water deprivation relationship: RO:0002211 GO:0009414 ! regulates response to water deprivation creation_date: 2010-08-23T11:32:32Z [Term] id: GO:2000074 name: regulation of type B pancreatic cell development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of pancreatic B cell development." [GOC:obol, GOC:yaf] synonym: "regulation of pancreatic B cell development" EXACT [GOC:mah] synonym: "regulation of pancreatic beta cell development" EXACT [GOC:obol] xref: Reactome:R-HSA-211163 "AKT-mediated inactivation of FOXO1A" is_a: GO:0060284 ! regulation of cell development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0003323 ! regulates type B pancreatic cell development relationship: RO:0002211 GO:0003323 ! regulates type B pancreatic cell development creation_date: 2010-08-27T11:19:37Z [Term] id: GO:2000077 name: negative regulation of type B pancreatic cell development namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of pancreatic B cell development." [GOC:obol, GOC:yaf] synonym: "negative regulation of pancreatic B cell development" EXACT [GOC:mah] synonym: "negative regulation of pancreatic beta cell development" EXACT [GOC:obol] is_a: GO:0010721 ! negative regulation of cell development is_a: GO:0051241 ! negative regulation of multicellular organismal process is_a: GO:2000074 ! regulation of type B pancreatic cell development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0003323 ! negatively regulates type B pancreatic cell development relationship: RO:0002212 GO:0003323 ! negatively regulates type B pancreatic cell development creation_date: 2010-08-27T11:21:17Z [Term] id: GO:2000078 name: positive regulation of type B pancreatic cell development namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of pancreatic B cell development." [GOC:obol, GOC:yaf] synonym: "positive regulation of pancreatic B cell development" EXACT [GOC:mah] synonym: "positive regulation of pancreatic beta cell development" EXACT [GOC:obol] is_a: GO:0010720 ! positive regulation of cell development is_a: GO:0030858 ! positive regulation of epithelial cell differentiation is_a: GO:0051240 ! positive regulation of multicellular organismal process is_a: GO:2000074 ! regulation of type B pancreatic cell development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0003323 ! positively regulates type B pancreatic cell development relationship: RO:0002213 GO:0003323 ! positively regulates type B pancreatic cell development creation_date: 2010-08-27T11:21:19Z [Term] id: GO:2000084 name: regulation of mesenchymal to epithelial transition involved in mesonephros morphogenesis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of mesenchymal to epithelial transition involved in mesonephros morphogenesis." [GOC:mtg_kidney_jan10] synonym: "regulation of mesonephric mesenchyme to epithelial transition" RELATED [GOC:obol] is_a: GO:2000696 ! regulation of epithelial cell differentiation involved in kidney development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0061261 ! regulates mesenchymal to epithelial transition involved in mesonephros morphogenesis relationship: RO:0002211 GO:0061261 ! regulates mesenchymal to epithelial transition involved in mesonephros morphogenesis creation_date: 2010-09-03T06:06:41Z [Term] id: GO:2000085 name: negative regulation of mesenchymal to epithelial transition involved in mesonephros morphogenesis namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of mesenchymal to epithelial transition involved in mesonephros morphogenesis." [GOC:mtg_kidney_jan10] synonym: "negative regulation of mesonephric mesenchyme to epithelial transition" RELATED [GOC:obol] is_a: GO:2000084 ! regulation of mesenchymal to epithelial transition involved in mesonephros morphogenesis is_a: GO:2000697 ! negative regulation of epithelial cell differentiation involved in kidney development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0061261 ! negatively regulates mesenchymal to epithelial transition involved in mesonephros morphogenesis relationship: RO:0002212 GO:0061261 ! negatively regulates mesenchymal to epithelial transition involved in mesonephros morphogenesis creation_date: 2010-09-03T06:08:21Z [Term] id: GO:2000086 name: positive regulation of mesenchymal to epithelial transition involved in mesonephros morphogenesis namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of mesenchymal to epithelial transition involved in mesonephros morphogenesis." [GOC:mtg_kidney_jan10] synonym: "positive regulation of mesonephric mesenchyme to epithelial transition" RELATED [GOC:obol] is_a: GO:2000084 ! regulation of mesenchymal to epithelial transition involved in mesonephros morphogenesis is_a: GO:2000698 ! positive regulation of epithelial cell differentiation involved in kidney development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0061261 ! positively regulates mesenchymal to epithelial transition involved in mesonephros morphogenesis relationship: RO:0002213 GO:0061261 ! positively regulates mesenchymal to epithelial transition involved in mesonephros morphogenesis creation_date: 2010-09-03T06:08:24Z [Term] id: GO:2000087 name: regulation of mesonephric glomerulus development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of mesonephric glomerulus development." [GOC:mtg_kidney_jan10] is_a: GO:0061217 ! regulation of mesonephros development is_a: GO:0090192 ! regulation of glomerulus development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0061224 ! regulates mesonephric glomerulus development relationship: RO:0002211 GO:0061224 ! regulates mesonephric glomerulus development creation_date: 2010-09-03T06:09:19Z [Term] id: GO:2000088 name: negative regulation of mesonephric glomerulus development namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of mesonephric glomerulus development." [GOC:mtg_kidney_jan10] is_a: GO:0090194 ! negative regulation of glomerulus development is_a: GO:2000087 ! regulation of mesonephric glomerulus development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0061224 ! negatively regulates mesonephric glomerulus development relationship: RO:0002212 GO:0061224 ! negatively regulates mesonephric glomerulus development creation_date: 2010-09-03T06:09:22Z [Term] id: GO:2000089 name: positive regulation of mesonephric glomerulus development namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of mesonephric glomerulus development." [GOC:mtg_kidney_jan10] is_a: GO:0090193 ! positive regulation of glomerulus development is_a: GO:2000087 ! regulation of mesonephric glomerulus development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0061224 ! positively regulates mesonephric glomerulus development relationship: RO:0002213 GO:0061224 ! positively regulates mesonephric glomerulus development creation_date: 2010-09-03T06:09:24Z [Term] id: GO:2000093 name: regulation of mesonephric nephron tubule epithelial cell differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of mesonephric nephron tubule epithelial cell differentiation." [GOC:mtg_kidney_jan10] is_a: GO:0072182 ! regulation of nephron tubule epithelial cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0061265 ! regulates mesonephric nephron tubule epithelial cell differentiation relationship: RO:0002211 GO:0061265 ! regulates mesonephric nephron tubule epithelial cell differentiation creation_date: 2010-09-03T06:12:25Z [Term] id: GO:2000094 name: negative regulation of mesonephric nephron tubule epithelial cell differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of mesonephric nephron tubule epithelial cell differentiation." [GOC:mtg_kidney_jan10] is_a: GO:0072183 ! negative regulation of nephron tubule epithelial cell differentiation is_a: GO:2000093 ! regulation of mesonephric nephron tubule epithelial cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0061265 ! negatively regulates mesonephric nephron tubule epithelial cell differentiation relationship: RO:0002212 GO:0061265 ! negatively regulates mesonephric nephron tubule epithelial cell differentiation creation_date: 2010-09-03T06:12:28Z [Term] id: GO:2000106 name: regulation of leukocyte apoptotic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of leukocyte apoptotic process." [GOC:BHF, GOC:mtg_apoptosis] synonym: "regulation of leukocyte apoptosis" NARROW [] is_a: GO:0042981 ! regulation of apoptotic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0071887 ! regulates leukocyte apoptotic process relationship: RO:0002211 GO:0071887 ! regulates leukocyte apoptotic process creation_date: 2010-09-15T01:42:05Z [Term] id: GO:2000107 name: negative regulation of leukocyte apoptotic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of leukocyte apoptotic process." [GOC:BHF, GOC:mtg_apoptosis] synonym: "negative regulation of leukocyte apoptosis" NARROW [] is_a: GO:0043066 ! negative regulation of apoptotic process is_a: GO:2000106 ! regulation of leukocyte apoptotic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0071887 ! negatively regulates leukocyte apoptotic process relationship: RO:0002212 GO:0071887 ! negatively regulates leukocyte apoptotic process creation_date: 2010-09-15T01:42:09Z [Term] id: GO:2000108 name: positive regulation of leukocyte apoptotic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of leukocyte apoptotic process." [GOC:BHF, GOC:mtg_apoptosis] synonym: "positive regulation of leukocyte apoptosis" NARROW [] is_a: GO:0043065 ! positive regulation of apoptotic process is_a: GO:2000106 ! regulation of leukocyte apoptotic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0071887 ! positively regulates leukocyte apoptotic process relationship: RO:0002213 GO:0071887 ! positively regulates leukocyte apoptotic process creation_date: 2010-09-15T01:42:12Z [Term] id: GO:2000109 name: regulation of macrophage apoptotic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of macrophage apoptotic process." [GOC:BHF, GOC:mtg_apoptosis] synonym: "regulation of activation-induced cell death" RELATED [GOC:yaf] synonym: "regulation of AICD" RELATED [GOC:yaf] synonym: "regulation of macrophage apoptosis" NARROW [] is_a: GO:0033032 ! regulation of myeloid cell apoptotic process is_a: GO:2000106 ! regulation of leukocyte apoptotic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0071888 ! regulates macrophage apoptotic process relationship: RO:0002211 GO:0071888 ! regulates macrophage apoptotic process creation_date: 2010-09-15T01:44:15Z [Term] id: GO:2000110 name: negative regulation of macrophage apoptotic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of macrophage apoptotic process." [GOC:BHF, GOC:mtg_apoptosis] synonym: "negative regulation of activation-induced cell death" RELATED [GOC:yaf] synonym: "negative regulation of AICD" RELATED [GOC:yaf] synonym: "negative regulation of macrophage apoptosis" NARROW [] is_a: GO:0033033 ! negative regulation of myeloid cell apoptotic process is_a: GO:2000107 ! negative regulation of leukocyte apoptotic process is_a: GO:2000109 ! regulation of macrophage apoptotic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0071888 ! negatively regulates macrophage apoptotic process relationship: RO:0002212 GO:0071888 ! negatively regulates macrophage apoptotic process creation_date: 2010-09-15T01:44:18Z [Term] id: GO:2000111 name: positive regulation of macrophage apoptotic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of macrophage apoptotic process." [GOC:BHF, GOC:mtg_apoptosis] synonym: "positive regulation of activation-induced cell death" RELATED [GOC:yaf] synonym: "positive regulation of AICD" RELATED [GOC:yaf] synonym: "positive regulation of macrophage apoptosis" NARROW [] is_a: GO:0033034 ! positive regulation of myeloid cell apoptotic process is_a: GO:2000108 ! positive regulation of leukocyte apoptotic process is_a: GO:2000109 ! regulation of macrophage apoptotic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0071888 ! positively regulates macrophage apoptotic process relationship: RO:0002213 GO:0071888 ! positively regulates macrophage apoptotic process creation_date: 2010-09-15T01:44:21Z [Term] id: GO:2000114 name: regulation of establishment of cell polarity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of establishment of cell polarity." [GOC:dph] synonym: "regulation of bud site selection/establishment of cell polarity" RELATED [GOC:obol] synonym: "regulation of cell polarization" EXACT [GOC:obol] is_a: GO:0032878 ! regulation of establishment or maintenance of cell polarity intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0030010 ! regulates establishment of cell polarity relationship: RO:0002211 GO:0030010 ! regulates establishment of cell polarity creation_date: 2010-09-16T01:22:36Z [Term] id: GO:2000136 name: regulation of cell proliferation involved in heart morphogenesis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cell proliferation involved in heart morphogenesis." [GOC:dph] is_a: GO:0042127 ! regulation of cell population proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0061323 ! regulates cell proliferation involved in heart morphogenesis relationship: RO:0002211 GO:0061323 ! regulates cell proliferation involved in heart morphogenesis creation_date: 2010-09-29T12:43:53Z [Term] id: GO:2000137 name: negative regulation of cell proliferation involved in heart morphogenesis namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cell proliferation involved in heart morphogenesis." [GOC:dph] is_a: GO:0008285 ! negative regulation of cell population proliferation is_a: GO:2000136 ! regulation of cell proliferation involved in heart morphogenesis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0061323 ! negatively regulates cell proliferation involved in heart morphogenesis relationship: RO:0002212 GO:0061323 ! negatively regulates cell proliferation involved in heart morphogenesis creation_date: 2010-09-29T12:43:55Z [Term] id: GO:2000138 name: positive regulation of cell proliferation involved in heart morphogenesis namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cell proliferation involved in heart morphogenesis." [GOC:dph] is_a: GO:0008284 ! positive regulation of cell population proliferation is_a: GO:2000136 ! regulation of cell proliferation involved in heart morphogenesis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0061323 ! positively regulates cell proliferation involved in heart morphogenesis relationship: RO:0002213 GO:0061323 ! positively regulates cell proliferation involved in heart morphogenesis creation_date: 2010-09-29T12:43:57Z [Term] id: GO:2000145 name: regulation of cell motility namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cell motility." [GOC:mah] synonym: "regulation of cell locomotion" EXACT [GOC:obol] synonym: "regulation of cell movement" RELATED [GOC:obol] synonym: "regulation of movement of a cell" EXACT [GOC:obol] xref: Reactome:R-HSA-6785631 "ERBB2 Regulates Cell Motility" is_a: GO:0040012 ! regulation of locomotion is_a: GO:0050794 ! regulation of cellular process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0048870 ! regulates cell motility relationship: RO:0002211 GO:0048870 ! regulates cell motility property_value: RO:0002161 NCBITaxon:451864 creation_date: 2010-10-01T09:41:21Z [Term] id: GO:2000146 name: negative regulation of cell motility namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cell motility." [GOC:mah] synonym: "negative regulation of cell locomotion" EXACT [GOC:obol] synonym: "negative regulation of cell movement" RELATED [GOC:obol] synonym: "negative regulation of movement of a cell" EXACT [GOC:obol] is_a: GO:0040013 ! negative regulation of locomotion is_a: GO:0048523 ! negative regulation of cellular process is_a: GO:2000145 ! regulation of cell motility intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0048870 ! negatively regulates cell motility relationship: RO:0002212 GO:0048870 ! negatively regulates cell motility property_value: RO:0002161 NCBITaxon:451864 creation_date: 2010-10-01T09:41:26Z [Term] id: GO:2000147 name: positive regulation of cell motility namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cell motility." [GOC:mah] synonym: "positive regulation of cell locomotion" EXACT [GOC:obol] synonym: "positive regulation of cell movement" RELATED [GOC:obol] synonym: "positive regulation of movement of a cell" EXACT [GOC:obol] is_a: GO:0040017 ! positive regulation of locomotion is_a: GO:0048522 ! positive regulation of cellular process is_a: GO:2000145 ! regulation of cell motility intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0048870 ! positively regulates cell motility relationship: RO:0002213 GO:0048870 ! positively regulates cell motility property_value: RO:0002161 NCBITaxon:451864 creation_date: 2010-10-01T09:41:30Z [Term] id: GO:2000155 name: positive regulation of cilium-dependent cell motility namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cilium-dependent cell motility." [GOC:cilia, GOC:jl] synonym: "positive regulation of ciliary cell motility" RELATED [] is_a: GO:1902019 ! regulation of cilium-dependent cell motility is_a: GO:2000147 ! positive regulation of cell motility intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0060285 ! positively regulates cilium-dependent cell motility relationship: RO:0002213 GO:0060285 ! positively regulates cilium-dependent cell motility property_value: RO:0002161 NCBITaxon:3176 property_value: RO:0002161 NCBITaxon:3378 property_value: RO:0002161 NCBITaxon:3398 property_value: RO:0002161 NCBITaxon:451864 property_value: RO:0002161 NCBITaxon:5782 creation_date: 2010-10-04T12:41:05Z [Term] id: GO:2000171 name: negative regulation of dendrite development namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of dendrite development." [GOC:obol] is_a: GO:0010977 ! negative regulation of neuron projection development is_a: GO:0050773 ! regulation of dendrite development is_a: GO:0051093 ! negative regulation of developmental process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0016358 ! negatively regulates dendrite development relationship: RO:0002212 GO:0016358 ! negatively regulates dendrite development creation_date: 2010-10-07T10:53:15Z [Term] id: GO:2000172 name: regulation of branching morphogenesis of a nerve namespace: biological_process def: "Any process that modulates the frequency, rate or extent of branching morphogenesis of a nerve." [GOC:BHF] is_a: GO:0060688 ! regulation of morphogenesis of a branching structure intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0048755 ! regulates branching morphogenesis of a nerve relationship: RO:0002211 GO:0048755 ! regulates branching morphogenesis of a nerve creation_date: 2010-10-07T12:07:54Z [Term] id: GO:2000173 name: negative regulation of branching morphogenesis of a nerve namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of branching morphogenesis of a nerve." [GOC:BHF] is_a: GO:0051093 ! negative regulation of developmental process is_a: GO:0051241 ! negative regulation of multicellular organismal process is_a: GO:2000172 ! regulation of branching morphogenesis of a nerve intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0048755 ! negatively regulates branching morphogenesis of a nerve relationship: RO:0002212 GO:0048755 ! negatively regulates branching morphogenesis of a nerve creation_date: 2010-10-07T12:07:56Z [Term] id: GO:2000174 name: regulation of pro-T cell differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of pro-T cell differentiation." [GOC:BHF] synonym: "regulation of pro-T lymphocyte differentiation" EXACT [GOC:obol] is_a: GO:0045580 ! regulation of T cell differentiation is_a: GO:1905456 ! regulation of lymphoid progenitor cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0002572 ! regulates pro-T cell differentiation relationship: RO:0002211 GO:0002572 ! regulates pro-T cell differentiation creation_date: 2010-10-11T10:24:30Z [Term] id: GO:2000175 name: negative regulation of pro-T cell differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of pro-T cell differentiation." [GOC:BHF] synonym: "negative regulation of pro-T lymphocyte differentiation" EXACT [GOC:obol] is_a: GO:0045581 ! negative regulation of T cell differentiation is_a: GO:1905457 ! negative regulation of lymphoid progenitor cell differentiation is_a: GO:2000174 ! regulation of pro-T cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0002572 ! negatively regulates pro-T cell differentiation relationship: RO:0002212 GO:0002572 ! negatively regulates pro-T cell differentiation creation_date: 2010-10-11T10:24:33Z [Term] id: GO:2000176 name: positive regulation of pro-T cell differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of pro-T cell differentiation." [GOC:BHF] synonym: "positive regulation of pro-T lymphocyte differentiation" EXACT [GOC:obol] is_a: GO:0045582 ! positive regulation of T cell differentiation is_a: GO:1905458 ! positive regulation of lymphoid progenitor cell differentiation is_a: GO:2000174 ! regulation of pro-T cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0002572 ! positively regulates pro-T cell differentiation relationship: RO:0002213 GO:0002572 ! positively regulates pro-T cell differentiation creation_date: 2010-10-11T10:24:35Z [Term] id: GO:2000177 name: regulation of neural precursor cell proliferation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of neural precursor cell proliferation." [GOC:dph, GOC:yaf] is_a: GO:0042127 ! regulation of cell population proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0061351 ! regulates neural precursor cell proliferation relationship: RO:0002211 GO:0061351 ! regulates neural precursor cell proliferation property_value: RO:0002161 NCBITaxon:4751 creation_date: 2010-10-13T12:40:41Z [Term] id: GO:2000178 name: negative regulation of neural precursor cell proliferation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of neural precursor cell proliferation." [GOC:dph, GOC:yaf] is_a: GO:0008285 ! negative regulation of cell population proliferation is_a: GO:2000177 ! regulation of neural precursor cell proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0061351 ! negatively regulates neural precursor cell proliferation relationship: RO:0002212 GO:0061351 ! negatively regulates neural precursor cell proliferation property_value: RO:0002161 NCBITaxon:4751 creation_date: 2010-10-13T12:40:43Z [Term] id: GO:2000179 name: positive regulation of neural precursor cell proliferation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of neural precursor cell proliferation." [GOC:dph, GOC:yaf] is_a: GO:0008284 ! positive regulation of cell population proliferation is_a: GO:2000177 ! regulation of neural precursor cell proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0061351 ! positively regulates neural precursor cell proliferation relationship: RO:0002213 GO:0061351 ! positively regulates neural precursor cell proliferation property_value: RO:0002161 NCBITaxon:4751 creation_date: 2010-10-13T12:40:45Z [Term] id: GO:2000181 name: negative regulation of blood vessel morphogenesis namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of blood vessel morphogenesis." [GOC:dph, GOC:yaf] is_a: GO:0022603 ! regulation of anatomical structure morphogenesis is_a: GO:1901343 ! negative regulation of vasculature development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0048514 ! negatively regulates blood vessel morphogenesis relationship: RO:0002212 GO:0048514 ! negatively regulates blood vessel morphogenesis creation_date: 2010-10-13T12:46:31Z [Term] id: GO:2000182 name: regulation of progesterone biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of progesterone biosynthetic process." [GOC:dph] synonym: "regulation of progesterone anabolism" EXACT [GOC:obol] synonym: "regulation of progesterone biosynthesis" EXACT [GOC:obol] synonym: "regulation of progesterone formation" EXACT [GOC:obol] synonym: "regulation of progesterone synthesis" EXACT [GOC:obol] is_a: GO:0010566 ! regulation of ketone biosynthetic process is_a: GO:0046885 ! regulation of hormone biosynthetic process is_a: GO:0050810 ! regulation of steroid biosynthetic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0006701 ! regulates progesterone biosynthetic process relationship: RO:0002211 GO:0006701 ! regulates progesterone biosynthetic process property_value: RO:0002161 NCBITaxon:4895 creation_date: 2010-10-14T07:36:06Z [Term] id: GO:2000183 name: negative regulation of progesterone biosynthetic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of progesterone biosynthetic process." [GOC:dph] synonym: "negative regulation of progesterone anabolism" EXACT [GOC:obol] synonym: "negative regulation of progesterone biosynthesis" EXACT [GOC:obol] synonym: "negative regulation of progesterone formation" EXACT [GOC:obol] synonym: "negative regulation of progesterone synthesis" EXACT [GOC:obol] is_a: GO:0010894 ! negative regulation of steroid biosynthetic process is_a: GO:0032353 ! negative regulation of hormone biosynthetic process is_a: GO:0062014 ! negative regulation of small molecule metabolic process is_a: GO:2000182 ! regulation of progesterone biosynthetic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0006701 ! negatively regulates progesterone biosynthetic process relationship: RO:0002212 GO:0006701 ! negatively regulates progesterone biosynthetic process property_value: RO:0002161 NCBITaxon:4895 creation_date: 2010-10-14T07:36:10Z [Term] id: GO:2000184 name: positive regulation of progesterone biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of progesterone biosynthetic process." [GOC:dph] synonym: "positive regulation of progesterone anabolism" EXACT [GOC:obol] synonym: "positive regulation of progesterone biosynthesis" EXACT [GOC:obol] synonym: "positive regulation of progesterone formation" EXACT [GOC:obol] synonym: "positive regulation of progesterone synthesis" EXACT [GOC:obol] is_a: GO:0010893 ! positive regulation of steroid biosynthetic process is_a: GO:0046886 ! positive regulation of hormone biosynthetic process is_a: GO:0062013 ! positive regulation of small molecule metabolic process is_a: GO:2000182 ! regulation of progesterone biosynthetic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0006701 ! positively regulates progesterone biosynthetic process relationship: RO:0002213 GO:0006701 ! positively regulates progesterone biosynthetic process property_value: RO:0002161 NCBITaxon:4895 creation_date: 2010-10-14T07:36:14Z [Term] id: GO:2000185 name: regulation of phosphate transmembrane transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of phosphate transmembrane transport." [GOC:obol] synonym: "regulation of phosphate membrane transport" EXACT [] is_a: GO:0010966 ! regulation of phosphate transport is_a: GO:0034762 ! regulation of transmembrane transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0035435 ! regulates phosphate ion transmembrane transport relationship: RO:0002211 GO:0035435 ! regulates phosphate ion transmembrane transport creation_date: 2010-10-15T11:33:04Z [Term] id: GO:2000186 name: negative regulation of phosphate transmembrane transport namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of phosphate transmembrane transport." [GOC:obol] synonym: "negative regulation of phosphate membrane transport" EXACT [] is_a: GO:0034763 ! negative regulation of transmembrane transport is_a: GO:2000185 ! regulation of phosphate transmembrane transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0035435 ! negatively regulates phosphate ion transmembrane transport relationship: RO:0002212 GO:0035435 ! negatively regulates phosphate ion transmembrane transport creation_date: 2010-10-15T11:33:08Z [Term] id: GO:2000187 name: positive regulation of phosphate transmembrane transport namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of phosphate transmembrane transport." [GOC:obol] synonym: "positive regulation of phosphate membrane transport" EXACT [] is_a: GO:0034764 ! positive regulation of transmembrane transport is_a: GO:2000185 ! regulation of phosphate transmembrane transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0035435 ! positively regulates phosphate ion transmembrane transport relationship: RO:0002213 GO:0035435 ! positively regulates phosphate ion transmembrane transport creation_date: 2010-10-15T11:33:10Z [Term] id: GO:2000191 name: regulation of fatty acid transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of fatty acid transport." [GOC:BHF] is_a: GO:0032368 ! regulation of lipid transport is_a: GO:0032890 ! regulation of organic acid transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0015908 ! regulates fatty acid transport relationship: RO:0002211 GO:0015908 ! regulates fatty acid transport creation_date: 2010-10-18T10:37:13Z [Term] id: GO:2000192 name: negative regulation of fatty acid transport namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of fatty acid transport." [GOC:BHF] is_a: GO:0032369 ! negative regulation of lipid transport is_a: GO:0032891 ! negative regulation of organic acid transport is_a: GO:2000191 ! regulation of fatty acid transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0015908 ! negatively regulates fatty acid transport relationship: RO:0002212 GO:0015908 ! negatively regulates fatty acid transport creation_date: 2010-10-18T10:37:15Z [Term] id: GO:2000193 name: positive regulation of fatty acid transport namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of fatty acid transport." [GOC:BHF] is_a: GO:0032370 ! positive regulation of lipid transport is_a: GO:0032892 ! positive regulation of organic acid transport is_a: GO:2000191 ! regulation of fatty acid transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0015908 ! positively regulates fatty acid transport relationship: RO:0002213 GO:0015908 ! positively regulates fatty acid transport creation_date: 2010-10-18T10:37:17Z [Term] id: GO:2000194 name: regulation of female gonad development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of female gonad development." [GOC:obol] synonym: "regulation of ovarian development" EXACT [GOC:obol] synonym: "regulation of ovary development" EXACT [GOC:obol] is_a: GO:1905939 ! regulation of gonad development is_a: GO:2000026 ! regulation of multicellular organismal development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0008585 ! regulates female gonad development relationship: RO:0002211 GO:0008585 ! regulates female gonad development creation_date: 2010-10-19T10:45:34Z [Term] id: GO:2000195 name: negative regulation of female gonad development namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of female gonad development." [GOC:obol] synonym: "negative regulation of ovarian development" EXACT [GOC:obol] synonym: "negative regulation of ovary development" EXACT [GOC:obol] is_a: GO:1905940 ! negative regulation of gonad development is_a: GO:2000194 ! regulation of female gonad development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0008585 ! negatively regulates female gonad development relationship: RO:0002212 GO:0008585 ! negatively regulates female gonad development creation_date: 2010-10-19T10:45:38Z [Term] id: GO:2000196 name: positive regulation of female gonad development namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of female gonad development." [GOC:obol] synonym: "positive regulation of ovarian development" EXACT [GOC:obol] synonym: "positive regulation of ovary development" EXACT [GOC:obol] is_a: GO:1905941 ! positive regulation of gonad development is_a: GO:2000194 ! regulation of female gonad development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0008585 ! positively regulates female gonad development relationship: RO:0002213 GO:0008585 ! positively regulates female gonad development creation_date: 2010-10-19T10:45:41Z [Term] id: GO:2000197 name: regulation of ribonucleoprotein complex localization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of ribonucleoprotein complex localization." [GOC:mah] synonym: "regulation of cellular ribonucleoprotein complex localization" EXACT [GOC:obol] synonym: "regulation of establishment and maintenance of ribonucleoprotein complex localization" EXACT [GOC:obol] synonym: "regulation of ribonucleoprotein complex localisation" EXACT [GOC:mah] synonym: "regulation of RNP localization" EXACT [GOC:obol] is_a: GO:0060341 ! regulation of cellular localization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0071166 ! regulates ribonucleoprotein complex localization relationship: RO:0002211 GO:0071166 ! regulates ribonucleoprotein complex localization creation_date: 2010-10-26T10:35:48Z [Term] id: GO:2000198 name: negative regulation of ribonucleoprotein complex localization namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of ribonucleoprotein complex localization." [GOC:mah] synonym: "negative regulation of cellular ribonucleoprotein complex localization" EXACT [GOC:obol] synonym: "negative regulation of establishment and maintenance of ribonucleoprotein complex localization" EXACT [GOC:obol] synonym: "negative regulation of ribonucleoprotein complex localisation" EXACT [GOC:mah] synonym: "negative regulation of RNP localization" EXACT [GOC:obol] is_a: GO:0048523 ! negative regulation of cellular process is_a: GO:2000197 ! regulation of ribonucleoprotein complex localization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0071166 ! negatively regulates ribonucleoprotein complex localization relationship: RO:0002212 GO:0071166 ! negatively regulates ribonucleoprotein complex localization creation_date: 2010-10-26T10:35:52Z [Term] id: GO:2000199 name: positive regulation of ribonucleoprotein complex localization namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of ribonucleoprotein complex localization." [GOC:mah] synonym: "positive regulation of cellular ribonucleoprotein complex localization" EXACT [GOC:obol] synonym: "positive regulation of establishment and maintenance of ribonucleoprotein complex localization" EXACT [GOC:obol] synonym: "positive regulation of ribonucleoprotein complex localisation" EXACT [GOC:mah] synonym: "positive regulation of RNP localization" EXACT [GOC:obol] is_a: GO:0048522 ! positive regulation of cellular process is_a: GO:2000197 ! regulation of ribonucleoprotein complex localization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0071166 ! positively regulates ribonucleoprotein complex localization relationship: RO:0002213 GO:0071166 ! positively regulates ribonucleoprotein complex localization creation_date: 2010-10-26T10:35:55Z [Term] id: GO:2000211 name: regulation of glutamate metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of glutamate metabolic process." [GOC:sl] synonym: "regulation of glutamate metabolism" EXACT [GOC:obol] synonym: "regulation of glutamic acid metabolic process" EXACT [GOC:obol] synonym: "regulation of glutamic acid metabolism" EXACT [GOC:obol] is_a: GO:0006521 ! regulation of amino acid metabolic process is_a: GO:0062012 ! regulation of small molecule metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0006536 ! regulates glutamate metabolic process relationship: RO:0002211 GO:0006536 ! regulates glutamate metabolic process creation_date: 2010-11-03T02:43:51Z [Term] id: GO:2000212 name: negative regulation of glutamate metabolic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of glutamate metabolic process." [GOC:sl] synonym: "negative regulation of glutamate metabolism" EXACT [GOC:obol] synonym: "negative regulation of glutamic acid metabolic process" EXACT [GOC:obol] synonym: "negative regulation of glutamic acid metabolism" EXACT [GOC:obol] is_a: GO:0045763 ! negative regulation of amino acid metabolic process is_a: GO:0062014 ! negative regulation of small molecule metabolic process is_a: GO:2000211 ! regulation of glutamate metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0006536 ! negatively regulates glutamate metabolic process relationship: RO:0002212 GO:0006536 ! negatively regulates glutamate metabolic process creation_date: 2010-11-03T02:43:55Z [Term] id: GO:2000224 name: regulation of testosterone biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of testosterone biosynthetic process." [GOC:obol, GOC:yaf] is_a: GO:0010566 ! regulation of ketone biosynthetic process is_a: GO:0050810 ! regulation of steroid biosynthetic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0061370 ! regulates testosterone biosynthetic process relationship: RO:0002211 GO:0061370 ! regulates testosterone biosynthetic process creation_date: 2010-11-09T10:38:33Z [Term] id: GO:2000225 name: negative regulation of testosterone biosynthetic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of testosterone biosynthetic process." [GOC:obol, GOC:yaf] is_a: GO:0010894 ! negative regulation of steroid biosynthetic process is_a: GO:0062014 ! negative regulation of small molecule metabolic process is_a: GO:2000224 ! regulation of testosterone biosynthetic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0061370 ! negatively regulates testosterone biosynthetic process relationship: RO:0002212 GO:0061370 ! negatively regulates testosterone biosynthetic process creation_date: 2010-11-09T10:38:37Z [Term] id: GO:2000226 name: regulation of pancreatic A cell differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of pancreatic A cell differentiation." [GOC:mah] synonym: "regulation of pancreatic alpha cell differentiation" EXACT [GOC:obol] is_a: GO:0030856 ! regulation of epithelial cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0003310 ! regulates pancreatic A cell differentiation relationship: RO:0002211 GO:0003310 ! regulates pancreatic A cell differentiation creation_date: 2010-11-09T03:43:37Z [Term] id: GO:2000227 name: negative regulation of pancreatic A cell differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of pancreatic A cell differentiation." [GOC:mah] synonym: "negative regulation of pancreatic alpha cell differentiation" EXACT [GOC:obol] is_a: GO:0030857 ! negative regulation of epithelial cell differentiation is_a: GO:0051241 ! negative regulation of multicellular organismal process is_a: GO:2000226 ! regulation of pancreatic A cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0003310 ! negatively regulates pancreatic A cell differentiation relationship: RO:0002212 GO:0003310 ! negatively regulates pancreatic A cell differentiation creation_date: 2010-11-09T03:43:40Z [Term] id: GO:2000228 name: positive regulation of pancreatic A cell differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of pancreatic A cell differentiation." [GOC:mah] synonym: "positive regulation of pancreatic alpha cell differentiation" EXACT [GOC:obol] is_a: GO:0030858 ! positive regulation of epithelial cell differentiation is_a: GO:0051240 ! positive regulation of multicellular organismal process is_a: GO:2000226 ! regulation of pancreatic A cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0003310 ! positively regulates pancreatic A cell differentiation relationship: RO:0002213 GO:0003310 ! positively regulates pancreatic A cell differentiation creation_date: 2010-11-09T03:43:42Z [Term] id: GO:2000229 name: regulation of pancreatic stellate cell proliferation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of pancreatic stellate cell proliferation." [GOC:mah] is_a: GO:0048145 ! regulation of fibroblast proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0072343 ! regulates pancreatic stellate cell proliferation relationship: RO:0002211 GO:0072343 ! regulates pancreatic stellate cell proliferation property_value: RO:0002161 NCBITaxon:4751 creation_date: 2010-11-09T03:45:18Z [Term] id: GO:2000230 name: negative regulation of pancreatic stellate cell proliferation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of pancreatic stellate cell proliferation." [GOC:mah] is_a: GO:0048147 ! negative regulation of fibroblast proliferation is_a: GO:2000229 ! regulation of pancreatic stellate cell proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0072343 ! negatively regulates pancreatic stellate cell proliferation relationship: RO:0002212 GO:0072343 ! negatively regulates pancreatic stellate cell proliferation property_value: RO:0002161 NCBITaxon:4751 creation_date: 2010-11-09T03:45:21Z [Term] id: GO:2000231 name: positive regulation of pancreatic stellate cell proliferation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of pancreatic stellate cell proliferation." [GOC:mah] is_a: GO:0048146 ! positive regulation of fibroblast proliferation is_a: GO:2000229 ! regulation of pancreatic stellate cell proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0072343 ! positively regulates pancreatic stellate cell proliferation relationship: RO:0002213 GO:0072343 ! positively regulates pancreatic stellate cell proliferation property_value: RO:0002161 NCBITaxon:4751 creation_date: 2010-11-09T03:45:23Z [Term] id: GO:2000238 name: regulation of tRNA export from nucleus namespace: biological_process def: "Any process that modulates the frequency, rate or extent of tRNA export from nucleus." [GOC:mah] synonym: "regulation of tRNA export from cell nucleus" EXACT [GOC:obol] synonym: "regulation of tRNA export out of nucleus" EXACT [GOC:obol] synonym: "regulation of tRNA transport from nucleus to cytoplasm" EXACT [GOC:obol] synonym: "regulation of tRNA-nucleus export" EXACT [GOC:obol] is_a: GO:0046831 ! regulation of RNA export from nucleus is_a: GO:2000197 ! regulation of ribonucleoprotein complex localization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0006409 ! regulates tRNA export from nucleus relationship: RO:0002211 GO:0006409 ! regulates tRNA export from nucleus creation_date: 2010-11-10T12:39:33Z [Term] id: GO:2000239 name: negative regulation of tRNA export from nucleus namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of tRNA export from nucleus." [GOC:mah] synonym: "negative regulation of tRNA export from cell nucleus" EXACT [GOC:obol] synonym: "negative regulation of tRNA export out of nucleus" EXACT [GOC:obol] synonym: "negative regulation of tRNA transport from nucleus to cytoplasm" EXACT [GOC:obol] synonym: "negative regulation of tRNA-nucleus export" EXACT [GOC:obol] is_a: GO:0046832 ! negative regulation of RNA export from nucleus is_a: GO:2000198 ! negative regulation of ribonucleoprotein complex localization is_a: GO:2000238 ! regulation of tRNA export from nucleus intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0006409 ! negatively regulates tRNA export from nucleus relationship: RO:0002212 GO:0006409 ! negatively regulates tRNA export from nucleus creation_date: 2010-11-10T12:39:36Z [Term] id: GO:2000240 name: positive regulation of tRNA export from nucleus namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of tRNA export from nucleus." [GOC:mah] synonym: "positive regulation of tRNA export from cell nucleus" EXACT [GOC:obol] synonym: "positive regulation of tRNA export out of nucleus" EXACT [GOC:obol] synonym: "positive regulation of tRNA transport from nucleus to cytoplasm" EXACT [GOC:obol] synonym: "positive regulation of tRNA-nucleus export" EXACT [GOC:obol] is_a: GO:0046833 ! positive regulation of RNA export from nucleus is_a: GO:2000199 ! positive regulation of ribonucleoprotein complex localization is_a: GO:2000238 ! regulation of tRNA export from nucleus intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0006409 ! positively regulates tRNA export from nucleus relationship: RO:0002213 GO:0006409 ! positively regulates tRNA export from nucleus creation_date: 2010-11-10T12:39:38Z [Term] id: GO:2000241 name: regulation of reproductive process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of reproductive process." [GOC:mah] subset: gocheck_do_not_annotate is_a: GO:0050789 ! regulation of biological process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0022414 ! regulates reproductive process relationship: RO:0002211 GO:0022414 ! regulates reproductive process creation_date: 2010-11-10T02:44:02Z [Term] id: GO:2000242 name: negative regulation of reproductive process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of reproductive process." [GOC:mah] is_a: GO:0048519 ! negative regulation of biological process is_a: GO:2000241 ! regulation of reproductive process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0022414 ! negatively regulates reproductive process relationship: RO:0002212 GO:0022414 ! negatively regulates reproductive process creation_date: 2010-11-10T02:44:05Z [Term] id: GO:2000243 name: positive regulation of reproductive process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of reproductive process." [GOC:mah] is_a: GO:0048518 ! positive regulation of biological process is_a: GO:2000241 ! regulation of reproductive process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0022414 ! positively regulates reproductive process relationship: RO:0002213 GO:0022414 ! positively regulates reproductive process creation_date: 2010-11-10T02:44:08Z [Term] id: GO:2000248 name: negative regulation of establishment or maintenance of neuroblast polarity namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of establishment or maintenance of neuroblast polarity." [GOC:obol] synonym: "negative regulation of establishment and/or maintenance of neuroblast cell polarity" EXACT [GOC:obol] is_a: GO:0010454 ! negative regulation of cell fate commitment is_a: GO:0032878 ! regulation of establishment or maintenance of cell polarity is_a: GO:0045769 ! negative regulation of asymmetric cell division intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0045196 ! negatively regulates establishment or maintenance of neuroblast polarity relationship: RO:0002212 GO:0045196 ! negatively regulates establishment or maintenance of neuroblast polarity creation_date: 2010-11-11T11:40:34Z [Term] id: GO:2000254 name: regulation of male germ cell proliferation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of male germ cell proliferation." [GOC:obol] is_a: GO:1905936 ! regulation of germ cell proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0002176 ! regulates male germ cell proliferation relationship: RO:0002211 GO:0002176 ! regulates male germ cell proliferation property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4751 creation_date: 2010-11-18T09:29:44Z [Term] id: GO:2000255 name: negative regulation of male germ cell proliferation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of male germ cell proliferation." [GOC:obol] is_a: GO:1905937 ! negative regulation of germ cell proliferation is_a: GO:2000242 ! negative regulation of reproductive process is_a: GO:2000254 ! regulation of male germ cell proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0002176 ! negatively regulates male germ cell proliferation relationship: RO:0002212 GO:0002176 ! negatively regulates male germ cell proliferation property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4751 creation_date: 2010-11-18T09:29:47Z [Term] id: GO:2000256 name: positive regulation of male germ cell proliferation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of male germ cell proliferation." [GOC:obol] is_a: GO:1905938 ! positive regulation of germ cell proliferation is_a: GO:2000243 ! positive regulation of reproductive process is_a: GO:2000254 ! regulation of male germ cell proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0002176 ! positively regulates male germ cell proliferation relationship: RO:0002213 GO:0002176 ! positively regulates male germ cell proliferation property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4751 creation_date: 2010-11-18T09:29:50Z [Term] id: GO:2000269 name: regulation of fibroblast apoptotic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of fibroblast apoptotic process." [GOC:mtg_apoptosis, GOC:obol, GOC:yaf] synonym: "regulation of fibroblast apoptosis" NARROW [] is_a: GO:0042981 ! regulation of apoptotic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0044346 ! regulates fibroblast apoptotic process relationship: RO:0002211 GO:0044346 ! regulates fibroblast apoptotic process property_value: RO:0002161 NCBITaxon:4896 creation_date: 2010-11-23T01:07:23Z [Term] id: GO:2000270 name: negative regulation of fibroblast apoptotic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of fibroblast apoptotic process." [GOC:mtg_apoptosis, GOC:obol, GOC:yaf] synonym: "negative regulation of fibroblast apoptosis" NARROW [] is_a: GO:0043066 ! negative regulation of apoptotic process is_a: GO:2000269 ! regulation of fibroblast apoptotic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0044346 ! negatively regulates fibroblast apoptotic process relationship: RO:0002212 GO:0044346 ! negatively regulates fibroblast apoptotic process property_value: RO:0002161 NCBITaxon:4896 creation_date: 2010-11-23T01:07:27Z [Term] id: GO:2000271 name: positive regulation of fibroblast apoptotic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of fibroblast apoptotic process." [GOC:mtg_apoptosis, GOC:obol, GOC:yaf] synonym: "positive regulation of fibroblast apoptosis" NARROW [] is_a: GO:0043065 ! positive regulation of apoptotic process is_a: GO:2000269 ! regulation of fibroblast apoptotic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0044346 ! positively regulates fibroblast apoptotic process relationship: RO:0002213 GO:0044346 ! positively regulates fibroblast apoptotic process property_value: RO:0002161 NCBITaxon:4896 creation_date: 2010-11-23T01:07:29Z [Term] id: GO:2000272 name: negative regulation of signaling receptor activity namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of a signaling receptor activity." [GOC:obol] subset: gocheck_obsoletion_candidate synonym: "negative regulation of receptor activity" BROAD [] synonym: "negative regulation of signalling receptor activity" EXACT [] is_a: GO:0010469 ! regulation of signaling receptor activity is_a: GO:0044092 ! negative regulation of molecular function intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0038023 ! negatively regulates signaling receptor activity relationship: RO:0002212 GO:0038023 ! negatively regulates signaling receptor activity creation_date: 2010-12-02T09:28:47Z [Term] id: GO:2000278 name: regulation of DNA biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of DNA biosynthetic process." [GOC:obol] synonym: "regulation of DNA anabolism" EXACT [GOC:obol] synonym: "regulation of DNA biosynthesis" EXACT [GOC:obol] synonym: "regulation of DNA formation" EXACT [GOC:obol] synonym: "regulation of DNA synthesis" EXACT [GOC:obol] is_a: GO:0010556 ! regulation of macromolecule biosynthetic process is_a: GO:0051052 ! regulation of DNA metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0071897 ! regulates DNA biosynthetic process relationship: RO:0002211 GO:0071897 ! regulates DNA biosynthetic process creation_date: 2010-12-08T04:48:15Z [Term] id: GO:2000279 name: negative regulation of DNA biosynthetic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of DNA biosynthetic process." [GOC:obol] synonym: "negative regulation of DNA anabolism" EXACT [GOC:obol] synonym: "negative regulation of DNA biosynthesis" EXACT [GOC:obol] synonym: "negative regulation of DNA formation" EXACT [GOC:obol] synonym: "negative regulation of DNA synthesis" EXACT [GOC:obol] is_a: GO:0010558 ! negative regulation of macromolecule biosynthetic process is_a: GO:0051053 ! negative regulation of DNA metabolic process is_a: GO:2000278 ! regulation of DNA biosynthetic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0071897 ! negatively regulates DNA biosynthetic process relationship: RO:0002212 GO:0071897 ! negatively regulates DNA biosynthetic process creation_date: 2010-12-08T04:48:20Z [Term] id: GO:2000282 name: regulation of amino acid biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cellular amino acid biosynthetic process." [GOC:obol] synonym: "regulation of cellular amino acid anabolism" EXACT [GOC:obol] synonym: "regulation of cellular amino acid biosynthesis" EXACT [GOC:obol] synonym: "regulation of cellular amino acid biosynthetic process" EXACT [GOC:obol] synonym: "regulation of cellular amino acid formation" EXACT [GOC:obol] synonym: "regulation of cellular amino acid synthesis" EXACT [GOC:obol] is_a: GO:0006521 ! regulation of amino acid metabolic process is_a: GO:0009889 ! regulation of biosynthetic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0008652 ! regulates amino acid biosynthetic process relationship: RO:0002211 GO:0008652 ! regulates amino acid biosynthetic process property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/28908" xsd:anyURI creation_date: 2010-12-10T11:54:19Z [Term] id: GO:2000283 name: negative regulation of amino acid biosynthetic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of an amino acid biosynthetic process." [GOC:obol] synonym: "negative regulation of amino acid anabolism" EXACT [GOC:obol] synonym: "negative regulation of amino acid biosynthesis" EXACT [GOC:obol] synonym: "negative regulation of amino acid formation" EXACT [GOC:obol] synonym: "negative regulation of amino acid synthesis" EXACT [GOC:obol] synonym: "negative regulation of cellular amino acid biosynthetic process" EXACT [GOC:obol] is_a: GO:0009890 ! negative regulation of biosynthetic process is_a: GO:0045763 ! negative regulation of amino acid metabolic process is_a: GO:2000282 ! regulation of amino acid biosynthetic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0008652 ! negatively regulates amino acid biosynthetic process relationship: RO:0002212 GO:0008652 ! negatively regulates amino acid biosynthetic process creation_date: 2010-12-10T11:54:23Z [Term] id: GO:2000284 name: positive regulation of amino acid biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cellular amino acid biosynthetic process." [GOC:obol] synonym: "positive regulation of amino acid anabolism" EXACT [GOC:obol] synonym: "positive regulation of amino acid biosynthesis" EXACT [GOC:obol] synonym: "positive regulation of amino acid formation" EXACT [GOC:obol] synonym: "positive regulation of amino acid synthesis" EXACT [GOC:obol] synonym: "positive regulation of cellular amino acid biosynthetic process" EXACT [GOC:obol] is_a: GO:0009891 ! positive regulation of biosynthetic process is_a: GO:0045764 ! positive regulation of amino acid metabolic process is_a: GO:2000282 ! regulation of amino acid biosynthetic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0008652 ! positively regulates amino acid biosynthetic process relationship: RO:0002213 GO:0008652 ! positively regulates amino acid biosynthetic process creation_date: 2010-12-10T11:54:27Z [Term] id: GO:2000287 name: positive regulation of myotome development namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of myotome development." [GOC:BHF] is_a: GO:0051094 ! positive regulation of developmental process is_a: GO:2000290 ! regulation of myotome development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0061055 ! positively regulates myotome development relationship: RO:0002213 GO:0061055 ! positively regulates myotome development creation_date: 2010-12-16T05:17:15Z [Term] id: GO:2000288 name: positive regulation of myoblast proliferation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of myoblast proliferation." [GOC:BHF] is_a: GO:0008284 ! positive regulation of cell population proliferation is_a: GO:2000291 ! regulation of myoblast proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0051450 ! positively regulates myoblast proliferation relationship: RO:0002213 GO:0051450 ! positively regulates myoblast proliferation property_value: RO:0002161 NCBITaxon:4751 creation_date: 2010-12-16T05:20:52Z [Term] id: GO:2000290 name: regulation of myotome development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of myotome development." [GOC:mah] is_a: GO:0050793 ! regulation of developmental process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0061055 ! regulates myotome development relationship: RO:0002211 GO:0061055 ! regulates myotome development creation_date: 2010-12-20T10:22:05Z [Term] id: GO:2000291 name: regulation of myoblast proliferation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of myoblast proliferation." [GOC:mah] is_a: GO:0042127 ! regulation of cell population proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0051450 ! regulates myoblast proliferation relationship: RO:0002211 GO:0051450 ! regulates myoblast proliferation property_value: RO:0002161 NCBITaxon:4751 creation_date: 2010-12-20T10:34:26Z [Term] id: GO:2000292 name: regulation of defecation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of defecation." [GOC:obol] is_a: GO:0044058 ! regulation of digestive system process is_a: GO:0044062 ! regulation of excretion intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0030421 ! regulates defecation relationship: RO:0002211 GO:0030421 ! regulates defecation property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 creation_date: 2010-12-21T09:23:08Z [Term] id: GO:2000293 name: negative regulation of defecation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of defecation." [GOC:obol] is_a: GO:0051048 ! negative regulation of secretion is_a: GO:0060457 ! negative regulation of digestive system process is_a: GO:2000292 ! regulation of defecation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0030421 ! negatively regulates defecation relationship: RO:0002212 GO:0030421 ! negatively regulates defecation property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 creation_date: 2010-12-21T09:23:13Z [Term] id: GO:2000294 name: positive regulation of defecation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of defecation." [GOC:obol] is_a: GO:0051047 ! positive regulation of secretion is_a: GO:0060456 ! positive regulation of digestive system process is_a: GO:2000292 ! regulation of defecation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0030421 ! positively regulates defecation relationship: RO:0002213 GO:0030421 ! positively regulates defecation property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 creation_date: 2010-12-21T09:23:16Z [Term] id: GO:2000300 name: regulation of synaptic vesicle exocytosis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of synaptic vesicle exocytosis." [GOC:obol] subset: goslim_synapse is_a: GO:0046928 ! regulation of neurotransmitter secretion is_a: GO:1903305 ! regulation of regulated secretory pathway intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0016079 ! regulates synaptic vesicle exocytosis relationship: RO:0002211 GO:0016079 ! regulates synaptic vesicle exocytosis creation_date: 2011-01-03T08:20:40Z [Term] id: GO:2000301 name: negative regulation of synaptic vesicle exocytosis namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of synaptic vesicle exocytosis." [GOC:obol] is_a: GO:1903306 ! negative regulation of regulated secretory pathway is_a: GO:2000300 ! regulation of synaptic vesicle exocytosis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0016079 ! negatively regulates synaptic vesicle exocytosis relationship: RO:0002212 GO:0016079 ! negatively regulates synaptic vesicle exocytosis creation_date: 2011-01-03T08:21:00Z [Term] id: GO:2000302 name: positive regulation of synaptic vesicle exocytosis namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of synaptic vesicle exocytosis." [GOC:obol] is_a: GO:0001956 ! positive regulation of neurotransmitter secretion is_a: GO:1903307 ! positive regulation of regulated secretory pathway is_a: GO:2000300 ! regulation of synaptic vesicle exocytosis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0016079 ! positively regulates synaptic vesicle exocytosis relationship: RO:0002213 GO:0016079 ! positively regulates synaptic vesicle exocytosis creation_date: 2011-01-03T08:21:14Z [Term] id: GO:2000316 name: regulation of T-helper 17 type immune response namespace: biological_process def: "Any process that modulates the frequency, rate or extent of T-helper 17 type immune response." [GOC:BHF, GOC:mah] synonym: "regulation of Th17 immune response" EXACT [GOC:obol] is_a: GO:0002822 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0072538 ! regulates T-helper 17 type immune response relationship: RO:0002211 GO:0072538 ! regulates T-helper 17 type immune response creation_date: 2011-01-18T01:32:26Z [Term] id: GO:2000317 name: negative regulation of T-helper 17 type immune response namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of T-helper 17 type immune response." [GOC:BHF, GOC:mah] synonym: "negative regulation of Th17 immune response" EXACT [GOC:obol] is_a: GO:0002823 ! negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains is_a: GO:2000316 ! regulation of T-helper 17 type immune response intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0072538 ! negatively regulates T-helper 17 type immune response relationship: RO:0002212 GO:0072538 ! negatively regulates T-helper 17 type immune response creation_date: 2011-01-18T01:33:00Z [Term] id: GO:2000318 name: positive regulation of T-helper 17 type immune response namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of T-helper 17 type immune response." [GOC:BHF, GOC:mah] synonym: "positive regulation of Th17 immune response" EXACT [GOC:obol] is_a: GO:0002824 ! positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains is_a: GO:2000316 ! regulation of T-helper 17 type immune response intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0072538 ! positively regulates T-helper 17 type immune response relationship: RO:0002213 GO:0072538 ! positively regulates T-helper 17 type immune response creation_date: 2011-01-18T01:33:24Z [Term] id: GO:2000319 name: regulation of T-helper 17 cell differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of T-helper 17 cell differentiation." [GOC:BHF, GOC:mah] synonym: "regulation of T-helper 17 cell development" RELATED [GOC:obol] is_a: GO:0045622 ! regulation of T-helper cell differentiation is_a: GO:2000316 ! regulation of T-helper 17 type immune response intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0072539 ! regulates T-helper 17 cell differentiation relationship: RO:0002211 GO:0072539 ! regulates T-helper 17 cell differentiation creation_date: 2011-01-18T01:43:48Z [Term] id: GO:2000320 name: negative regulation of T-helper 17 cell differentiation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of T-helper 17 cell differentiation." [GOC:BHF, GOC:mah] synonym: "negative regulation of T-helper 17 cell development" RELATED [GOC:obol] is_a: GO:0045623 ! negative regulation of T-helper cell differentiation is_a: GO:2000317 ! negative regulation of T-helper 17 type immune response is_a: GO:2000319 ! regulation of T-helper 17 cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0072539 ! negatively regulates T-helper 17 cell differentiation relationship: RO:0002212 GO:0072539 ! negatively regulates T-helper 17 cell differentiation creation_date: 2011-01-18T01:44:31Z [Term] id: GO:2000321 name: positive regulation of T-helper 17 cell differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of T-helper 17 cell differentiation." [GOC:BHF, GOC:mah] synonym: "positive regulation of T-helper 17 cell development" RELATED [GOC:obol] is_a: GO:0045624 ! positive regulation of T-helper cell differentiation is_a: GO:2000318 ! positive regulation of T-helper 17 type immune response is_a: GO:2000319 ! regulation of T-helper 17 cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0072539 ! positively regulates T-helper 17 cell differentiation relationship: RO:0002213 GO:0072539 ! positively regulates T-helper 17 cell differentiation creation_date: 2011-01-18T01:45:08Z [Term] id: GO:2000331 name: regulation of terminal button organization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of terminal button organization." [GOC:BHF, GOC:mah] synonym: "regulation of bouton organization" EXACT [GOC:obol] synonym: "regulation of presynaptic bouton organization" EXACT [GOC:obol] synonym: "regulation of synaptic bouton organization" EXACT [GOC:obol] synonym: "regulation of terminal bouton organization" EXACT [GOC:obol] synonym: "regulation of terminal button organisation" EXACT [GOC:obol] is_a: GO:0099174 ! regulation of presynapse organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0072553 ! regulates terminal button organization relationship: RO:0002211 GO:0072553 ! regulates terminal button organization creation_date: 2011-01-28T11:29:08Z [Term] id: GO:2000351 name: regulation of endothelial cell apoptotic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of endothelial cell apoptotic process." [GOC:mah, GOC:mtg_apoptosis] synonym: "regulation of apoptosis of endothelial cells" EXACT [GOC:obol] synonym: "regulation of endothelial cell apoptosis" NARROW [] synonym: "regulation of endothelial cell programmed cell death by apoptosis" EXACT [GOC:obol] synonym: "regulation of killing of endothelial cells" EXACT [GOC:obol] synonym: "regulation of programmed cell death of endothelial cells by apoptosis" EXACT [GOC:obol] synonym: "regulation of programmed cell death, endothelial cells" EXACT [GOC:obol] is_a: GO:0042981 ! regulation of apoptotic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0072577 ! regulates endothelial cell apoptotic process relationship: RO:0002211 GO:0072577 ! regulates endothelial cell apoptotic process property_value: RO:0002161 NCBITaxon:4896 creation_date: 2011-02-03T10:43:16Z [Term] id: GO:2000352 name: negative regulation of endothelial cell apoptotic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of endothelial cell apoptotic process." [GOC:BHF, GOC:mah, GOC:mtg_apoptosis] synonym: "negative regulation of apoptosis of endothelial cells" EXACT [GOC:obol] synonym: "negative regulation of endothelial cell apoptosis" NARROW [] synonym: "negative regulation of endothelial cell programmed cell death by apoptosis" EXACT [GOC:obol] synonym: "negative regulation of killing of endothelial cells" EXACT [GOC:obol] synonym: "negative regulation of programmed cell death of endothelial cells by apoptosis" EXACT [GOC:obol] synonym: "negative regulation of programmed cell death, endothelial cells" EXACT [GOC:obol] is_a: GO:0043066 ! negative regulation of apoptotic process is_a: GO:2000351 ! regulation of endothelial cell apoptotic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0072577 ! negatively regulates endothelial cell apoptotic process relationship: RO:0002212 GO:0072577 ! negatively regulates endothelial cell apoptotic process property_value: RO:0002161 NCBITaxon:4896 creation_date: 2011-02-03T10:43:20Z [Term] id: GO:2000353 name: positive regulation of endothelial cell apoptotic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of endothelial cell apoptotic process." [GOC:BHF, GOC:mah, GOC:mtg_apoptosis] synonym: "positive regulation of apoptosis of endothelial cells" EXACT [GOC:obol] synonym: "positive regulation of endothelial cell apoptosis" NARROW [] synonym: "positive regulation of endothelial cell programmed cell death by apoptosis" EXACT [GOC:obol] synonym: "positive regulation of killing of endothelial cells" EXACT [GOC:obol] synonym: "positive regulation of programmed cell death of endothelial cells by apoptosis" EXACT [GOC:obol] synonym: "positive regulation of programmed cell death, endothelial cells" EXACT [GOC:obol] is_a: GO:0043065 ! positive regulation of apoptotic process is_a: GO:2000351 ! regulation of endothelial cell apoptotic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0072577 ! positively regulates endothelial cell apoptotic process relationship: RO:0002213 GO:0072577 ! positively regulates endothelial cell apoptotic process property_value: RO:0002161 NCBITaxon:4896 creation_date: 2011-02-03T10:43:23Z [Term] id: GO:2000354 name: regulation of ovarian follicle development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of ovarian follicle development." [GOC:obol] synonym: "regulation of follicular phase" RELATED [GOC:obol] is_a: GO:0050793 ! regulation of developmental process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0001541 ! regulates ovarian follicle development relationship: RO:0002211 GO:0001541 ! regulates ovarian follicle development creation_date: 2011-02-03T02:01:28Z [Term] id: GO:2000355 name: negative regulation of ovarian follicle development namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of ovarian follicle development." [GOC:obol] synonym: "negative regulation of follicular phase" RELATED [GOC:obol] is_a: GO:0051093 ! negative regulation of developmental process is_a: GO:2000354 ! regulation of ovarian follicle development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0001541 ! negatively regulates ovarian follicle development relationship: RO:0002212 GO:0001541 ! negatively regulates ovarian follicle development creation_date: 2011-02-03T02:01:32Z [Term] id: GO:2000374 name: regulation of oxygen metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of oxygen metabolic process." [GOC:mah] synonym: "regulation of diatomic oxygen metabolic process" EXACT [GOC:obol] synonym: "regulation of oxygen metabolism" EXACT [GOC:obol] is_a: GO:0019222 ! regulation of metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0072592 ! regulates oxygen metabolic process relationship: RO:0002211 GO:0072592 ! regulates oxygen metabolic process creation_date: 2011-02-11T02:03:32Z [Term] id: GO:2000377 name: regulation of reactive oxygen species metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of reactive oxygen species metabolic process." [GOC:mah] synonym: "regulation of reactive oxygen species metabolism" EXACT [GOC:obol] synonym: "regulation of ROS metabolic process" EXACT [GOC:obol] is_a: GO:0019222 ! regulation of metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0072593 ! regulates reactive oxygen species metabolic process relationship: RO:0002211 GO:0072593 ! regulates reactive oxygen species metabolic process creation_date: 2011-02-11T02:06:36Z [Term] id: GO:2000378 name: negative regulation of reactive oxygen species metabolic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of reactive oxygen species metabolic process." [GOC:mah] synonym: "negative regulation of reactive oxygen species metabolism" EXACT [GOC:obol] synonym: "negative regulation of ROS metabolic process" EXACT [GOC:obol] is_a: GO:0009892 ! negative regulation of metabolic process is_a: GO:2000377 ! regulation of reactive oxygen species metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0072593 ! negatively regulates reactive oxygen species metabolic process relationship: RO:0002212 GO:0072593 ! negatively regulates reactive oxygen species metabolic process creation_date: 2011-02-11T02:06:49Z [Term] id: GO:2000379 name: positive regulation of reactive oxygen species metabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of reactive oxygen species metabolic process." [GOC:mah] synonym: "positive regulation of reactive oxygen species metabolism" EXACT [GOC:obol] synonym: "positive regulation of ROS metabolic process" EXACT [GOC:obol] is_a: GO:0009893 ! positive regulation of metabolic process is_a: GO:2000377 ! regulation of reactive oxygen species metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0072593 ! positively regulates reactive oxygen species metabolic process relationship: RO:0002213 GO:0072593 ! positively regulates reactive oxygen species metabolic process creation_date: 2011-02-11T02:06:57Z [Term] id: GO:2000380 name: regulation of mesoderm development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of mesoderm development." [GOC:BHF] is_a: GO:0050793 ! regulation of developmental process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0007498 ! regulates mesoderm development relationship: RO:0002211 GO:0007498 ! regulates mesoderm development creation_date: 2011-02-15T03:09:46Z [Term] id: GO:2000381 name: negative regulation of mesoderm development namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of mesoderm development." [GOC:BHF] is_a: GO:0051093 ! negative regulation of developmental process is_a: GO:2000380 ! regulation of mesoderm development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0007498 ! negatively regulates mesoderm development relationship: RO:0002212 GO:0007498 ! negatively regulates mesoderm development creation_date: 2011-02-15T03:10:02Z [Term] id: GO:2000382 name: positive regulation of mesoderm development namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of mesoderm development." [GOC:BHF] is_a: GO:0051094 ! positive regulation of developmental process is_a: GO:2000380 ! regulation of mesoderm development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0007498 ! positively regulates mesoderm development relationship: RO:0002213 GO:0007498 ! positively regulates mesoderm development creation_date: 2011-02-15T03:10:12Z [Term] id: GO:2000383 name: regulation of ectoderm development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of ectoderm development." [GOC:BHF] is_a: GO:0050793 ! regulation of developmental process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0007398 ! regulates ectoderm development relationship: RO:0002211 GO:0007398 ! regulates ectoderm development creation_date: 2011-02-15T03:17:10Z [Term] id: GO:2000384 name: negative regulation of ectoderm development namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of ectoderm development." [GOC:BHF] is_a: GO:0051093 ! negative regulation of developmental process is_a: GO:2000383 ! regulation of ectoderm development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0007398 ! negatively regulates ectoderm development relationship: RO:0002212 GO:0007398 ! negatively regulates ectoderm development creation_date: 2011-02-15T03:17:27Z [Term] id: GO:2000385 name: positive regulation of ectoderm development namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of ectoderm development." [GOC:BHF] is_a: GO:0051094 ! positive regulation of developmental process is_a: GO:2000383 ! regulation of ectoderm development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0007398 ! positively regulates ectoderm development relationship: RO:0002213 GO:0007398 ! positively regulates ectoderm development creation_date: 2011-02-15T03:17:39Z [Term] id: GO:2000386 name: positive regulation of ovarian follicle development namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of ovarian follicle development." [GOC:obol] synonym: "positive regulation of follicular phase" RELATED [GOC:obol] is_a: GO:0051094 ! positive regulation of developmental process is_a: GO:2000354 ! regulation of ovarian follicle development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0001541 ! positively regulates ovarian follicle development relationship: RO:0002213 GO:0001541 ! positively regulates ovarian follicle development creation_date: 2011-02-16T02:21:21Z [Term] id: GO:2000387 name: regulation of antral ovarian follicle growth namespace: biological_process def: "Any process that modulates the frequency, rate or extent of antral ovarian follicle growth." [GOC:obol] is_a: GO:0048638 ! regulation of developmental growth is_a: GO:2000241 ! regulation of reproductive process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0001547 ! regulates antral ovarian follicle growth relationship: RO:0002211 GO:0001547 ! regulates antral ovarian follicle growth creation_date: 2011-02-16T04:53:43Z [Term] id: GO:2000388 name: positive regulation of antral ovarian follicle growth namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of antral ovarian follicle growth." [GOC:obol] is_a: GO:0048639 ! positive regulation of developmental growth is_a: GO:2000243 ! positive regulation of reproductive process is_a: GO:2000387 ! regulation of antral ovarian follicle growth intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0001547 ! positively regulates antral ovarian follicle growth relationship: RO:0002213 GO:0001547 ! positively regulates antral ovarian follicle growth creation_date: 2011-02-16T04:54:01Z [Term] id: GO:2000401 name: regulation of lymphocyte migration namespace: biological_process def: "Any process that modulates the frequency, rate or extent of lymphocyte migration." [GOC:mah] is_a: GO:0071675 ! regulation of mononuclear cell migration intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0072676 ! regulates lymphocyte migration relationship: RO:0002211 GO:0072676 ! regulates lymphocyte migration creation_date: 2011-02-23T10:45:19Z [Term] id: GO:2000402 name: negative regulation of lymphocyte migration namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of lymphocyte migration." [GOC:mah] is_a: GO:0071676 ! negative regulation of mononuclear cell migration is_a: GO:2000401 ! regulation of lymphocyte migration intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0072676 ! negatively regulates lymphocyte migration relationship: RO:0002212 GO:0072676 ! negatively regulates lymphocyte migration creation_date: 2011-02-23T10:45:47Z [Term] id: GO:2000403 name: positive regulation of lymphocyte migration namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of lymphocyte migration." [GOC:mah] is_a: GO:0071677 ! positive regulation of mononuclear cell migration is_a: GO:2000401 ! regulation of lymphocyte migration intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0072676 ! positively regulates lymphocyte migration relationship: RO:0002213 GO:0072676 ! positively regulates lymphocyte migration creation_date: 2011-02-23T10:46:06Z [Term] id: GO:2000404 name: regulation of T cell migration namespace: biological_process def: "Any process that modulates the frequency, rate or extent of T cell migration." [GOC:mah] synonym: "regulation of T lymphocyte migration" EXACT [GOC:obol] synonym: "regulation of T-cell migration" EXACT [GOC:obol] synonym: "regulation of T-lymphocyte migration" EXACT [GOC:obol] is_a: GO:2000401 ! regulation of lymphocyte migration intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0072678 ! regulates T cell migration relationship: RO:0002211 GO:0072678 ! regulates T cell migration creation_date: 2011-02-23T10:48:24Z [Term] id: GO:2000405 name: negative regulation of T cell migration namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of T cell migration." [GOC:mah] synonym: "negative regulation of T lymphocyte migration" EXACT [GOC:obol] synonym: "negative regulation of T-cell migration" EXACT [GOC:obol] synonym: "negative regulation of T-lymphocyte migration" EXACT [GOC:obol] is_a: GO:2000402 ! negative regulation of lymphocyte migration is_a: GO:2000404 ! regulation of T cell migration intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0072678 ! negatively regulates T cell migration relationship: RO:0002212 GO:0072678 ! negatively regulates T cell migration creation_date: 2011-02-23T10:48:52Z [Term] id: GO:2000406 name: positive regulation of T cell migration namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of T cell migration." [GOC:mah] synonym: "positive regulation of T lymphocyte migration" EXACT [GOC:obol] synonym: "positive regulation of T-cell migration" EXACT [GOC:obol] synonym: "positive regulation of T-lymphocyte migration" EXACT [GOC:obol] is_a: GO:2000403 ! positive regulation of lymphocyte migration is_a: GO:2000404 ! regulation of T cell migration intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0072678 ! positively regulates T cell migration relationship: RO:0002213 GO:0072678 ! positively regulates T cell migration creation_date: 2011-02-23T10:49:12Z [Term] id: GO:2000410 name: regulation of thymocyte migration namespace: biological_process def: "Any process that modulates the frequency, rate or extent of thymocyte migration." [GOC:mah] synonym: "regulation of immature T cell migration" RELATED [GOC:obol] synonym: "regulation of immature T lymphocyte migration" RELATED [GOC:obol] synonym: "regulation of immature T-cell migration" RELATED [GOC:obol] synonym: "regulation of immature T-lymphocyte migration" RELATED [GOC:obol] synonym: "regulation of thymic lymphocyte migration" EXACT [GOC:obol] is_a: GO:2000404 ! regulation of T cell migration intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0072679 ! regulates thymocyte migration relationship: RO:0002211 GO:0072679 ! regulates thymocyte migration creation_date: 2011-02-23T01:33:32Z [Term] id: GO:2000411 name: negative regulation of thymocyte migration namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of thymocyte migration." [GOC:mah] synonym: "negative regulation of immature T cell migration" RELATED [GOC:obol] synonym: "negative regulation of immature T lymphocyte migration" RELATED [GOC:obol] synonym: "negative regulation of immature T-cell migration" RELATED [GOC:obol] synonym: "negative regulation of immature T-lymphocyte migration" RELATED [GOC:obol] synonym: "negative regulation of thymic lymphocyte migration" EXACT [GOC:obol] is_a: GO:2000405 ! negative regulation of T cell migration is_a: GO:2000410 ! regulation of thymocyte migration intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0072679 ! negatively regulates thymocyte migration relationship: RO:0002212 GO:0072679 ! negatively regulates thymocyte migration creation_date: 2011-02-23T01:34:01Z [Term] id: GO:2000412 name: positive regulation of thymocyte migration namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of thymocyte migration." [GOC:mah] synonym: "positive regulation of immature T cell migration" RELATED [GOC:obol] synonym: "positive regulation of immature T lymphocyte migration" RELATED [GOC:obol] synonym: "positive regulation of immature T-cell migration" RELATED [GOC:obol] synonym: "positive regulation of immature T-lymphocyte migration" RELATED [GOC:obol] synonym: "positive regulation of thymic lymphocyte migration" EXACT [GOC:obol] is_a: GO:2000406 ! positive regulation of T cell migration is_a: GO:2000410 ! regulation of thymocyte migration intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0072679 ! positively regulates thymocyte migration relationship: RO:0002213 GO:0072679 ! positively regulates thymocyte migration creation_date: 2011-02-23T01:34:23Z [Term] id: GO:2000416 name: regulation of eosinophil migration namespace: biological_process def: "Any process that modulates the frequency, rate or extent of eosinophil migration." [GOC:mah] is_a: GO:0002685 ! regulation of leukocyte migration intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0072677 ! regulates eosinophil migration relationship: RO:0002211 GO:0072677 ! regulates eosinophil migration creation_date: 2011-02-23T01:43:23Z [Term] id: GO:2000417 name: negative regulation of eosinophil migration namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of eosinophil migration." [GOC:mah] is_a: GO:0002686 ! negative regulation of leukocyte migration is_a: GO:2000416 ! regulation of eosinophil migration intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0072677 ! negatively regulates eosinophil migration relationship: RO:0002212 GO:0072677 ! negatively regulates eosinophil migration creation_date: 2011-02-23T01:43:52Z [Term] id: GO:2000418 name: positive regulation of eosinophil migration namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of eosinophil migration." [GOC:mah] is_a: GO:0002687 ! positive regulation of leukocyte migration is_a: GO:2000416 ! regulation of eosinophil migration intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0072677 ! positively regulates eosinophil migration relationship: RO:0002213 GO:0072677 ! positively regulates eosinophil migration creation_date: 2011-02-23T01:44:14Z [Term] id: GO:2000422 name: regulation of eosinophil chemotaxis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of eosinophil chemotaxis." [GOC:obol] is_a: GO:0071622 ! regulation of granulocyte chemotaxis is_a: GO:2000416 ! regulation of eosinophil migration intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0048245 ! regulates eosinophil chemotaxis relationship: RO:0002211 GO:0048245 ! regulates eosinophil chemotaxis creation_date: 2011-02-24T01:16:44Z [Term] id: GO:2000423 name: negative regulation of eosinophil chemotaxis namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of eosinophil chemotaxis." [GOC:obol] is_a: GO:0071623 ! negative regulation of granulocyte chemotaxis is_a: GO:2000417 ! negative regulation of eosinophil migration is_a: GO:2000422 ! regulation of eosinophil chemotaxis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0048245 ! negatively regulates eosinophil chemotaxis relationship: RO:0002212 GO:0048245 ! negatively regulates eosinophil chemotaxis creation_date: 2011-02-24T01:17:12Z [Term] id: GO:2000424 name: positive regulation of eosinophil chemotaxis namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of eosinophil chemotaxis." [GOC:obol] is_a: GO:0071624 ! positive regulation of granulocyte chemotaxis is_a: GO:2000418 ! positive regulation of eosinophil migration is_a: GO:2000422 ! regulation of eosinophil chemotaxis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0048245 ! positively regulates eosinophil chemotaxis relationship: RO:0002213 GO:0048245 ! positively regulates eosinophil chemotaxis creation_date: 2011-02-24T01:17:35Z [Term] id: GO:2000425 name: regulation of apoptotic cell clearance namespace: biological_process def: "Any process that modulates the frequency, rate or extent of apoptotic cell clearance." [GOC:obol] synonym: "regulation of apoptotic cell removal" EXACT [GOC:obol] synonym: "regulation of efferocytosis" EXACT [GOC:obol] synonym: "regulation of programmed cell clearance" EXACT [GOC:obol] is_a: GO:0050764 ! regulation of phagocytosis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0043277 ! regulates apoptotic cell clearance relationship: RO:0002211 GO:0043277 ! regulates apoptotic cell clearance property_value: RO:0002161 NCBITaxon:4751 creation_date: 2011-02-25T11:50:11Z [Term] id: GO:2000426 name: negative regulation of apoptotic cell clearance namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of apoptotic cell clearance." [GOC:obol] synonym: "negative regulation of apoptotic cell removal" EXACT [GOC:obol] synonym: "negative regulation of efferocytosis" EXACT [GOC:obol] synonym: "negative regulation of programmed cell clearance" EXACT [GOC:obol] is_a: GO:0050765 ! negative regulation of phagocytosis is_a: GO:2000425 ! regulation of apoptotic cell clearance intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0043277 ! negatively regulates apoptotic cell clearance relationship: RO:0002212 GO:0043277 ! negatively regulates apoptotic cell clearance property_value: RO:0002161 NCBITaxon:4751 creation_date: 2011-02-25T11:50:39Z [Term] id: GO:2000427 name: positive regulation of apoptotic cell clearance namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of apoptotic cell clearance." [GOC:obol] synonym: "positive regulation of apoptotic cell removal" EXACT [GOC:obol] synonym: "positive regulation of efferocytosis" EXACT [GOC:obol] synonym: "positive regulation of programmed cell clearance" EXACT [GOC:obol] is_a: GO:0050766 ! positive regulation of phagocytosis is_a: GO:2000425 ! regulation of apoptotic cell clearance intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0043277 ! positively regulates apoptotic cell clearance relationship: RO:0002213 GO:0043277 ! positively regulates apoptotic cell clearance property_value: RO:0002161 NCBITaxon:4751 creation_date: 2011-02-25T11:50:59Z [Term] id: GO:2000458 name: regulation of astrocyte chemotaxis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of astrocyte chemotaxis." [GOC:obol] is_a: GO:0050920 ! regulation of chemotaxis is_a: GO:1903975 ! regulation of glial cell migration intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0035700 ! regulates astrocyte chemotaxis relationship: RO:0002211 GO:0035700 ! regulates astrocyte chemotaxis creation_date: 2011-03-04T10:53:50Z [Term] id: GO:2000459 name: negative regulation of astrocyte chemotaxis namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of astrocyte chemotaxis." [GOC:obol] is_a: GO:0050922 ! negative regulation of chemotaxis is_a: GO:1903976 ! negative regulation of glial cell migration is_a: GO:2000458 ! regulation of astrocyte chemotaxis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0035700 ! negatively regulates astrocyte chemotaxis relationship: RO:0002212 GO:0035700 ! negatively regulates astrocyte chemotaxis creation_date: 2011-03-04T10:54:28Z [Term] id: GO:2000463 name: positive regulation of excitatory postsynaptic potential namespace: biological_process def: "Any process that enhances the establishment or increases the extent of the excitatory postsynaptic potential (EPSP) which is a temporary increase in postsynaptic potential due to the flow of positively charged ions into the postsynaptic cell. The flow of ions that causes an EPSP is an excitatory postsynaptic current (EPSC) and makes it easier for the neuron to fire an action potential." [GOC:bf, GOC:BHF] synonym: "positive regulation of EPSP" RELATED [GOC:bf, GOC:obol] synonym: "positive regulation of excitatory post-synaptic membrane potential" EXACT [] is_a: GO:0009967 ! positive regulation of signal transduction is_a: GO:0098815 ! modulation of excitatory postsynaptic potential intersection_of: GO:0050789 ! regulation of biological process intersection_of: RO:0002213 GO:0060079 ! positively regulates excitatory postsynaptic potential relationship: RO:0002213 GO:0060079 ! positively regulates excitatory postsynaptic potential creation_date: 2011-03-04T02:43:32Z [Term] id: GO:2000464 name: positive regulation of astrocyte chemotaxis namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of astrocyte chemotaxis." [GOC:obol] is_a: GO:0050921 ! positive regulation of chemotaxis is_a: GO:1903977 ! positive regulation of glial cell migration is_a: GO:2000458 ! regulation of astrocyte chemotaxis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0035700 ! positively regulates astrocyte chemotaxis relationship: RO:0002213 GO:0035700 ! positively regulates astrocyte chemotaxis creation_date: 2011-03-04T04:43:29Z [Term] id: GO:2000471 name: regulation of hematopoietic stem cell migration namespace: biological_process def: "Any process that modulates the frequency, rate or extent of hematopoietic stem cell migration." [GOC:obol] synonym: "regulation of hemopoietic stem cell migration" EXACT [GOC:obol] is_a: GO:0030334 ! regulation of cell migration intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0035701 ! regulates hematopoietic stem cell migration relationship: RO:0002211 GO:0035701 ! regulates hematopoietic stem cell migration property_value: RO:0002161 NCBITaxon:451864 creation_date: 2011-03-09T09:34:08Z [Term] id: GO:2000472 name: negative regulation of hematopoietic stem cell migration namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of hematopoietic stem cell migration." [GOC:obol] synonym: "negative regulation of hemopoietic stem cell migration" EXACT [GOC:obol] is_a: GO:0030336 ! negative regulation of cell migration is_a: GO:2000471 ! regulation of hematopoietic stem cell migration intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0035701 ! negatively regulates hematopoietic stem cell migration relationship: RO:0002212 GO:0035701 ! negatively regulates hematopoietic stem cell migration property_value: RO:0002161 NCBITaxon:451864 creation_date: 2011-03-09T09:34:54Z [Term] id: GO:2000473 name: positive regulation of hematopoietic stem cell migration namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of hematopoietic stem cell migration." [GOC:obol] synonym: "positive regulation of hemopoietic stem cell migration" EXACT [GOC:obol] is_a: GO:0030335 ! positive regulation of cell migration is_a: GO:2000471 ! regulation of hematopoietic stem cell migration intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0035701 ! positively regulates hematopoietic stem cell migration relationship: RO:0002213 GO:0035701 ! positively regulates hematopoietic stem cell migration property_value: RO:0002161 NCBITaxon:451864 creation_date: 2011-03-09T09:35:25Z [Term] id: GO:2000477 name: regulation of metanephric podocyte development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of metanephric glomerular visceral epithelial cell development." [GOC:obol] synonym: "regulation of metanephric glomerular visceral epithelial cell development" EXACT [] is_a: GO:0060284 ! regulation of cell development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0072249 ! regulates metanephric podocyte development relationship: RO:0002211 GO:0072249 ! regulates metanephric podocyte development property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/23000" xsd:anyURI creation_date: 2011-03-09T05:16:40Z [Term] id: GO:2000478 name: positive regulation of metanephric podocyte development namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of metanephric glomerular visceral epithelial cell development." [GOC:obol] synonym: "positive regulation of metanephric glomerular visceral epithelial cell development" EXACT [] is_a: GO:0010720 ! positive regulation of cell development is_a: GO:2000477 ! regulation of metanephric podocyte development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0072249 ! positively regulates metanephric podocyte development relationship: RO:0002213 GO:0072249 ! positively regulates metanephric podocyte development property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/23000" xsd:anyURI creation_date: 2011-03-09T05:17:26Z [Term] id: GO:2000489 name: regulation of hepatic stellate cell activation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of hepatic stellate cell activation." [GOC:obol] is_a: GO:0050865 ! regulation of cell activation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0035733 ! regulates hepatic stellate cell activation relationship: RO:0002211 GO:0035733 ! regulates hepatic stellate cell activation creation_date: 2011-03-14T03:48:32Z [Term] id: GO:2000490 name: negative regulation of hepatic stellate cell activation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of hepatic stellate cell activation." [GOC:obol] is_a: GO:0050866 ! negative regulation of cell activation is_a: GO:2000489 ! regulation of hepatic stellate cell activation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0035733 ! negatively regulates hepatic stellate cell activation relationship: RO:0002212 GO:0035733 ! negatively regulates hepatic stellate cell activation creation_date: 2011-03-14T03:49:18Z [Term] id: GO:2000491 name: positive regulation of hepatic stellate cell activation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of hepatic stellate cell activation." [GOC:obol] is_a: GO:0050867 ! positive regulation of cell activation is_a: GO:2000489 ! regulation of hepatic stellate cell activation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0035733 ! positively regulates hepatic stellate cell activation relationship: RO:0002213 GO:0035733 ! positively regulates hepatic stellate cell activation creation_date: 2011-03-14T03:49:48Z [Term] id: GO:2000495 name: regulation of cell proliferation involved in compound eye morphogenesis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cell proliferation involved in compound eye morphogenesis." [GOC:obol] is_a: GO:0042127 ! regulation of cell population proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0035736 ! regulates cell proliferation involved in compound eye morphogenesis relationship: RO:0002211 GO:0035736 ! regulates cell proliferation involved in compound eye morphogenesis creation_date: 2011-03-18T02:18:34Z [Term] id: GO:2000496 name: negative regulation of cell proliferation involved in compound eye morphogenesis namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of cell proliferation involved in compound eye morphogenesis." [GOC:obol] is_a: GO:0008285 ! negative regulation of cell population proliferation is_a: GO:2000495 ! regulation of cell proliferation involved in compound eye morphogenesis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0035736 ! negatively regulates cell proliferation involved in compound eye morphogenesis relationship: RO:0002212 GO:0035736 ! negatively regulates cell proliferation involved in compound eye morphogenesis creation_date: 2011-03-18T02:19:22Z [Term] id: GO:2000497 name: positive regulation of cell proliferation involved in compound eye morphogenesis namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cell proliferation involved in compound eye morphogenesis." [GOC:obol] is_a: GO:0008284 ! positive regulation of cell population proliferation is_a: GO:2000495 ! regulation of cell proliferation involved in compound eye morphogenesis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0035736 ! positively regulates cell proliferation involved in compound eye morphogenesis relationship: RO:0002213 GO:0035736 ! positively regulates cell proliferation involved in compound eye morphogenesis creation_date: 2011-03-18T02:19:54Z [Term] id: GO:2000501 name: regulation of natural killer cell chemotaxis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of natural killer cell chemotaxis." [GOC:BHF] is_a: GO:1901623 ! regulation of lymphocyte chemotaxis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0035747 ! regulates natural killer cell chemotaxis relationship: RO:0002211 GO:0035747 ! regulates natural killer cell chemotaxis creation_date: 2011-03-21T10:09:23Z [Term] id: GO:2000502 name: negative regulation of natural killer cell chemotaxis namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of natural killer cell chemotaxis." [GOC:BHF] is_a: GO:1901624 ! negative regulation of lymphocyte chemotaxis is_a: GO:2000501 ! regulation of natural killer cell chemotaxis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0035747 ! negatively regulates natural killer cell chemotaxis relationship: RO:0002212 GO:0035747 ! negatively regulates natural killer cell chemotaxis creation_date: 2011-03-21T10:09:32Z [Term] id: GO:2000503 name: positive regulation of natural killer cell chemotaxis namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of natural killer cell chemotaxis." [GOC:BHF] is_a: GO:0140131 ! positive regulation of lymphocyte chemotaxis is_a: GO:2000501 ! regulation of natural killer cell chemotaxis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0035747 ! positively regulates natural killer cell chemotaxis relationship: RO:0002213 GO:0035747 ! positively regulates natural killer cell chemotaxis creation_date: 2011-03-21T10:09:38Z [Term] id: GO:2000504 name: positive regulation of blood vessel remodeling namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of blood vessel remodeling." [GOC:obol] synonym: "positive regulation of blood vessel remodelling" EXACT [] is_a: GO:0034105 ! positive regulation of tissue remodeling is_a: GO:0060312 ! regulation of blood vessel remodeling intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0001974 ! positively regulates blood vessel remodeling relationship: RO:0002213 GO:0001974 ! positively regulates blood vessel remodeling property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 creation_date: 2011-03-21T10:33:20Z [Term] id: GO:2000508 name: regulation of dendritic cell chemotaxis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of dendritic cell chemotaxis." [GOC:obol] is_a: GO:0002688 ! regulation of leukocyte chemotaxis is_a: GO:0071675 ! regulation of mononuclear cell migration intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0002407 ! regulates dendritic cell chemotaxis relationship: RO:0002211 GO:0002407 ! regulates dendritic cell chemotaxis creation_date: 2011-03-22T10:21:38Z [Term] id: GO:2000509 name: negative regulation of dendritic cell chemotaxis namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of dendritic cell chemotaxis." [GOC:obol] is_a: GO:0002689 ! negative regulation of leukocyte chemotaxis is_a: GO:0071676 ! negative regulation of mononuclear cell migration is_a: GO:2000508 ! regulation of dendritic cell chemotaxis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0002407 ! negatively regulates dendritic cell chemotaxis relationship: RO:0002212 GO:0002407 ! negatively regulates dendritic cell chemotaxis creation_date: 2011-03-22T10:21:45Z [Term] id: GO:2000510 name: positive regulation of dendritic cell chemotaxis namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of dendritic cell chemotaxis." [GOC:obol] is_a: GO:0002690 ! positive regulation of leukocyte chemotaxis is_a: GO:0071677 ! positive regulation of mononuclear cell migration is_a: GO:2000508 ! regulation of dendritic cell chemotaxis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0002407 ! positively regulates dendritic cell chemotaxis relationship: RO:0002213 GO:0002407 ! positively regulates dendritic cell chemotaxis creation_date: 2011-03-22T10:21:49Z [Term] id: GO:2000514 name: regulation of CD4-positive, alpha-beta T cell activation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of CD4-positive, alpha-beta T cell activation." [GOC:obol] is_a: GO:0046634 ! regulation of alpha-beta T cell activation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0035710 ! regulates CD4-positive, alpha-beta T cell activation relationship: RO:0002211 GO:0035710 ! regulates CD4-positive, alpha-beta T cell activation creation_date: 2011-03-22T10:36:56Z [Term] id: GO:2000515 name: negative regulation of CD4-positive, alpha-beta T cell activation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of CD4-positive, alpha-beta T cell activation." [GOC:obol] is_a: GO:0046636 ! negative regulation of alpha-beta T cell activation is_a: GO:2000514 ! regulation of CD4-positive, alpha-beta T cell activation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0035710 ! negatively regulates CD4-positive, alpha-beta T cell activation relationship: RO:0002212 GO:0035710 ! negatively regulates CD4-positive, alpha-beta T cell activation creation_date: 2011-03-22T10:37:02Z [Term] id: GO:2000516 name: positive regulation of CD4-positive, alpha-beta T cell activation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of CD4-positive, alpha-beta T cell activation." [GOC:obol] is_a: GO:0046635 ! positive regulation of alpha-beta T cell activation is_a: GO:2000514 ! regulation of CD4-positive, alpha-beta T cell activation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0035710 ! positively regulates CD4-positive, alpha-beta T cell activation relationship: RO:0002213 GO:0035710 ! positively regulates CD4-positive, alpha-beta T cell activation creation_date: 2011-03-22T10:37:06Z [Term] id: GO:2000517 name: regulation of T-helper 1 cell activation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of T-helper 1 cell activation." [GOC:obol] synonym: "regulation of Th1 cell activation" EXACT [GOC:obol] is_a: GO:2000514 ! regulation of CD4-positive, alpha-beta T cell activation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0035711 ! regulates T-helper 1 cell activation relationship: RO:0002211 GO:0035711 ! regulates T-helper 1 cell activation creation_date: 2011-03-22T10:40:19Z [Term] id: GO:2000518 name: negative regulation of T-helper 1 cell activation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of T-helper 1 cell activation." [GOC:obol] synonym: "negative regulation of Th1 cell activation" EXACT [GOC:obol] is_a: GO:2000515 ! negative regulation of CD4-positive, alpha-beta T cell activation is_a: GO:2000517 ! regulation of T-helper 1 cell activation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0035711 ! negatively regulates T-helper 1 cell activation relationship: RO:0002212 GO:0035711 ! negatively regulates T-helper 1 cell activation creation_date: 2011-03-22T10:40:26Z [Term] id: GO:2000519 name: positive regulation of T-helper 1 cell activation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of T-helper 1 cell activation." [GOC:obol] synonym: "positive regulation of Th1 cell activation" EXACT [GOC:obol] is_a: GO:2000516 ! positive regulation of CD4-positive, alpha-beta T cell activation is_a: GO:2000517 ! regulation of T-helper 1 cell activation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0035711 ! positively regulates T-helper 1 cell activation relationship: RO:0002213 GO:0035711 ! positively regulates T-helper 1 cell activation creation_date: 2011-03-22T10:40:31Z [Term] id: GO:2000523 name: regulation of T cell costimulation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of T cell costimulation." [GOC:obol] synonym: "regulation of T cell co-stimulation" EXACT [GOC:obol] synonym: "regulation of T lymphocyte costimulation" EXACT [GOC:obol] synonym: "regulation of T-cell co-stimulation" EXACT [GOC:obol] synonym: "regulation of T-cell costimulation" EXACT [GOC:obol] synonym: "regulation of T-lymphocyte costimulation" EXACT [GOC:obol] is_a: GO:0050863 ! regulation of T cell activation is_a: GO:1903037 ! regulation of leukocyte cell-cell adhesion intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0031295 ! regulates T cell costimulation relationship: RO:0002211 GO:0031295 ! regulates T cell costimulation creation_date: 2011-03-23T10:23:24Z [Term] id: GO:2000524 name: negative regulation of T cell costimulation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of T cell costimulation." [GOC:obol] synonym: "negative regulation of T cell co-stimulation" EXACT [GOC:obol] synonym: "negative regulation of T lymphocyte costimulation" EXACT [GOC:obol] synonym: "negative regulation of T-cell co-stimulation" EXACT [GOC:obol] synonym: "negative regulation of T-cell costimulation" EXACT [GOC:obol] synonym: "negative regulation of T-lymphocyte costimulation" EXACT [GOC:obol] is_a: GO:0002683 ! negative regulation of immune system process is_a: GO:2000523 ! regulation of T cell costimulation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0031295 ! negatively regulates T cell costimulation relationship: RO:0002212 GO:0031295 ! negatively regulates T cell costimulation creation_date: 2011-03-23T10:23:31Z [Term] id: GO:2000525 name: positive regulation of T cell costimulation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of T cell costimulation." [GOC:obol] synonym: "positive regulation of T cell co-stimulation" EXACT [GOC:obol] synonym: "positive regulation of T lymphocyte costimulation" EXACT [GOC:obol] synonym: "positive regulation of T-cell co-stimulation" EXACT [GOC:obol] synonym: "positive regulation of T-cell costimulation" EXACT [GOC:obol] synonym: "positive regulation of T-lymphocyte costimulation" EXACT [GOC:obol] is_a: GO:0050870 ! positive regulation of T cell activation is_a: GO:2000523 ! regulation of T cell costimulation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0031295 ! positively regulates T cell costimulation relationship: RO:0002213 GO:0031295 ! positively regulates T cell costimulation creation_date: 2011-03-23T10:23:36Z [Term] id: GO:2000527 name: regulation of myeloid dendritic cell chemotaxis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of myeloid dendritic cell chemotaxis." [GOC:obol] is_a: GO:2000508 ! regulation of dendritic cell chemotaxis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0002408 ! regulates myeloid dendritic cell chemotaxis relationship: RO:0002211 GO:0002408 ! regulates myeloid dendritic cell chemotaxis creation_date: 2011-03-23T12:18:32Z [Term] id: GO:2000528 name: negative regulation of myeloid dendritic cell chemotaxis namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of myeloid dendritic cell chemotaxis." [GOC:obol] is_a: GO:2000509 ! negative regulation of dendritic cell chemotaxis is_a: GO:2000527 ! regulation of myeloid dendritic cell chemotaxis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0002408 ! negatively regulates myeloid dendritic cell chemotaxis relationship: RO:0002212 GO:0002408 ! negatively regulates myeloid dendritic cell chemotaxis creation_date: 2011-03-23T12:18:39Z [Term] id: GO:2000529 name: positive regulation of myeloid dendritic cell chemotaxis namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of myeloid dendritic cell chemotaxis." [GOC:obol] is_a: GO:2000510 ! positive regulation of dendritic cell chemotaxis is_a: GO:2000527 ! regulation of myeloid dendritic cell chemotaxis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0002408 ! positively regulates myeloid dendritic cell chemotaxis relationship: RO:0002213 GO:0002408 ! positively regulates myeloid dendritic cell chemotaxis creation_date: 2011-03-23T12:18:45Z [Term] id: GO:2000537 name: regulation of B cell chemotaxis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of B cell chemotaxis." [GOC:obol] is_a: GO:1901623 ! regulation of lymphocyte chemotaxis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0035754 ! regulates B cell chemotaxis relationship: RO:0002211 GO:0035754 ! regulates B cell chemotaxis creation_date: 2011-03-29T09:49:25Z [Term] id: GO:2000538 name: positive regulation of B cell chemotaxis namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of B cell chemotaxis." [GOC:obol] is_a: GO:0140131 ! positive regulation of lymphocyte chemotaxis is_a: GO:2000537 ! regulation of B cell chemotaxis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0035754 ! positively regulates B cell chemotaxis relationship: RO:0002213 GO:0035754 ! positively regulates B cell chemotaxis creation_date: 2011-03-29T09:49:33Z [Term] id: GO:2000542 name: negative regulation of gastrulation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of gastrulation." [GOC:obol] is_a: GO:0010470 ! regulation of gastrulation is_a: GO:0045992 ! negative regulation of embryonic development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0007369 ! negatively regulates gastrulation relationship: RO:0002212 GO:0007369 ! negatively regulates gastrulation creation_date: 2011-04-01T04:10:08Z [Term] id: GO:2000543 name: positive regulation of gastrulation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of gastrulation." [GOC:obol] is_a: GO:0010470 ! regulation of gastrulation is_a: GO:0040019 ! positive regulation of embryonic development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0007369 ! positively regulates gastrulation relationship: RO:0002213 GO:0007369 ! positively regulates gastrulation creation_date: 2011-04-01T04:10:15Z [Term] id: GO:2000547 name: regulation of dendritic cell dendrite assembly namespace: biological_process def: "Any process that modulates the frequency, rate or extent of dendritic cell dendrite assembly." [GOC:obol] synonym: "regulation of dendritic extension" RELATED [GOC:obol] is_a: GO:0120032 ! regulation of plasma membrane bounded cell projection assembly intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0097026 ! regulates dendritic cell dendrite assembly relationship: RO:0002211 GO:0097026 ! regulates dendritic cell dendrite assembly creation_date: 2011-04-03T07:21:55Z [Term] id: GO:2000548 name: negative regulation of dendritic cell dendrite assembly namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of dendritic cell dendrite assembly." [GOC:obol] synonym: "negative regulation of dendritic extension" RELATED [GOC:obol] is_a: GO:0120033 ! negative regulation of plasma membrane bounded cell projection assembly is_a: GO:2000547 ! regulation of dendritic cell dendrite assembly intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0097026 ! negatively regulates dendritic cell dendrite assembly relationship: RO:0002212 GO:0097026 ! negatively regulates dendritic cell dendrite assembly creation_date: 2011-04-03T07:22:01Z [Term] id: GO:2000549 name: positive regulation of dendritic cell dendrite assembly namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of dendritic cell dendrite assembly." [GOC:obol] synonym: "positive regulation of dendritic extension" RELATED [GOC:obol] is_a: GO:0120034 ! positive regulation of plasma membrane bounded cell projection assembly is_a: GO:2000547 ! regulation of dendritic cell dendrite assembly intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0097026 ! positively regulates dendritic cell dendrite assembly relationship: RO:0002213 GO:0097026 ! positively regulates dendritic cell dendrite assembly creation_date: 2011-04-03T07:22:06Z [Term] id: GO:2000550 name: negative regulation of B cell chemotaxis namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of B cell chemotaxis." [GOC:obol] is_a: GO:1901624 ! negative regulation of lymphocyte chemotaxis is_a: GO:2000537 ! regulation of B cell chemotaxis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0035754 ! negatively regulates B cell chemotaxis relationship: RO:0002212 GO:0035754 ! negatively regulates B cell chemotaxis creation_date: 2011-04-03T07:25:59Z [Term] id: GO:2000551 name: regulation of T-helper 2 cell cytokine production namespace: biological_process def: "Any process that modulates the frequency, rate or extent of T-helper 2 cell cytokine production." [GOC:obol] synonym: "regulation of Th2 cell cytokine production" EXACT [GOC:obol] is_a: GO:0002724 ! regulation of T cell cytokine production is_a: GO:0002828 ! regulation of type 2 immune response intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0035745 ! regulates T-helper 2 cell cytokine production relationship: RO:0002211 GO:0035745 ! regulates T-helper 2 cell cytokine production creation_date: 2011-04-03T07:32:47Z [Term] id: GO:2000552 name: negative regulation of T-helper 2 cell cytokine production namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of T-helper 2 cell cytokine production." [GOC:obol] synonym: "negative regulation of Th2 cell cytokine production" EXACT [GOC:obol] is_a: GO:0002725 ! negative regulation of T cell cytokine production is_a: GO:0002829 ! negative regulation of type 2 immune response is_a: GO:2000551 ! regulation of T-helper 2 cell cytokine production intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0035745 ! negatively regulates T-helper 2 cell cytokine production relationship: RO:0002212 GO:0035745 ! negatively regulates T-helper 2 cell cytokine production creation_date: 2011-04-03T07:32:54Z [Term] id: GO:2000553 name: positive regulation of T-helper 2 cell cytokine production namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of T-helper 2 cell cytokine production." [GOC:obol] synonym: "positive regulation of Th2 cell cytokine production" EXACT [GOC:obol] is_a: GO:0002726 ! positive regulation of T cell cytokine production is_a: GO:0002830 ! positive regulation of type 2 immune response is_a: GO:2000551 ! regulation of T-helper 2 cell cytokine production intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0035745 ! positively regulates T-helper 2 cell cytokine production relationship: RO:0002213 GO:0035745 ! positively regulates T-helper 2 cell cytokine production creation_date: 2011-04-03T07:32:58Z [Term] id: GO:2000554 name: regulation of T-helper 1 cell cytokine production namespace: biological_process def: "Any process that modulates the frequency, rate or extent of T-helper 1 cell cytokine production." [GOC:obol] synonym: "regulation of Th1 cell cytokine production" EXACT [GOC:obol] is_a: GO:0002724 ! regulation of T cell cytokine production is_a: GO:0002825 ! regulation of T-helper 1 type immune response intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0035744 ! regulates T-helper 1 cell cytokine production relationship: RO:0002211 GO:0035744 ! regulates T-helper 1 cell cytokine production creation_date: 2011-04-03T07:35:43Z [Term] id: GO:2000555 name: negative regulation of T-helper 1 cell cytokine production namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of T-helper 1 cell cytokine production." [GOC:obol] synonym: "negative regulation of Th1 cell cytokine production" EXACT [GOC:obol] is_a: GO:0002725 ! negative regulation of T cell cytokine production is_a: GO:0002826 ! negative regulation of T-helper 1 type immune response is_a: GO:2000554 ! regulation of T-helper 1 cell cytokine production intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0035744 ! negatively regulates T-helper 1 cell cytokine production relationship: RO:0002212 GO:0035744 ! negatively regulates T-helper 1 cell cytokine production creation_date: 2011-04-03T07:35:51Z [Term] id: GO:2000556 name: positive regulation of T-helper 1 cell cytokine production namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of T-helper 1 cell cytokine production." [GOC:obol] synonym: "positive regulation of Th1 cell cytokine production" EXACT [GOC:obol] is_a: GO:0002726 ! positive regulation of T cell cytokine production is_a: GO:0002827 ! positive regulation of T-helper 1 type immune response is_a: GO:2000554 ! regulation of T-helper 1 cell cytokine production intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0035744 ! positively regulates T-helper 1 cell cytokine production relationship: RO:0002213 GO:0035744 ! positively regulates T-helper 1 cell cytokine production creation_date: 2011-04-03T07:35:56Z [Term] id: GO:2000561 name: regulation of CD4-positive, alpha-beta T cell proliferation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of CD4-positive, alpha-beta T cell proliferation." [GOC:obol] is_a: GO:0046640 ! regulation of alpha-beta T cell proliferation is_a: GO:2000514 ! regulation of CD4-positive, alpha-beta T cell activation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0035739 ! regulates CD4-positive, alpha-beta T cell proliferation relationship: RO:0002211 GO:0035739 ! regulates CD4-positive, alpha-beta T cell proliferation creation_date: 2011-04-03T09:01:04Z [Term] id: GO:2000562 name: negative regulation of CD4-positive, alpha-beta T cell proliferation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of CD4-positive, alpha-beta T cell proliferation." [GOC:obol] is_a: GO:0046642 ! negative regulation of alpha-beta T cell proliferation is_a: GO:2000515 ! negative regulation of CD4-positive, alpha-beta T cell activation is_a: GO:2000561 ! regulation of CD4-positive, alpha-beta T cell proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0035739 ! negatively regulates CD4-positive, alpha-beta T cell proliferation relationship: RO:0002212 GO:0035739 ! negatively regulates CD4-positive, alpha-beta T cell proliferation creation_date: 2011-04-03T09:01:11Z [Term] id: GO:2000563 name: positive regulation of CD4-positive, alpha-beta T cell proliferation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of CD4-positive, alpha-beta T cell proliferation." [GOC:obol] is_a: GO:0046641 ! positive regulation of alpha-beta T cell proliferation is_a: GO:2000516 ! positive regulation of CD4-positive, alpha-beta T cell activation is_a: GO:2000561 ! regulation of CD4-positive, alpha-beta T cell proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0035739 ! positively regulates CD4-positive, alpha-beta T cell proliferation relationship: RO:0002213 GO:0035739 ! positively regulates CD4-positive, alpha-beta T cell proliferation creation_date: 2011-04-03T09:01:15Z [Term] id: GO:2000564 name: regulation of CD8-positive, alpha-beta T cell proliferation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of CD8-positive, alpha-beta T cell proliferation." [GOC:obol] is_a: GO:0046640 ! regulation of alpha-beta T cell proliferation is_a: GO:2001185 ! regulation of CD8-positive, alpha-beta T cell activation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0035740 ! regulates CD8-positive, alpha-beta T cell proliferation relationship: RO:0002211 GO:0035740 ! regulates CD8-positive, alpha-beta T cell proliferation creation_date: 2011-04-03T09:03:13Z [Term] id: GO:2000565 name: negative regulation of CD8-positive, alpha-beta T cell proliferation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of CD8-positive, alpha-beta T cell proliferation." [GOC:obol] is_a: GO:0046642 ! negative regulation of alpha-beta T cell proliferation is_a: GO:2000564 ! regulation of CD8-positive, alpha-beta T cell proliferation is_a: GO:2001186 ! negative regulation of CD8-positive, alpha-beta T cell activation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0035740 ! negatively regulates CD8-positive, alpha-beta T cell proliferation relationship: RO:0002212 GO:0035740 ! negatively regulates CD8-positive, alpha-beta T cell proliferation creation_date: 2011-04-03T09:03:19Z [Term] id: GO:2000566 name: positive regulation of CD8-positive, alpha-beta T cell proliferation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of CD8-positive, alpha-beta T cell proliferation." [GOC:obol] is_a: GO:0046641 ! positive regulation of alpha-beta T cell proliferation is_a: GO:2000564 ! regulation of CD8-positive, alpha-beta T cell proliferation is_a: GO:2001187 ! positive regulation of CD8-positive, alpha-beta T cell activation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0035740 ! positively regulates CD8-positive, alpha-beta T cell proliferation relationship: RO:0002213 GO:0035740 ! positively regulates CD8-positive, alpha-beta T cell proliferation creation_date: 2011-04-03T09:03:24Z [Term] id: GO:2000567 name: regulation of memory T cell activation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of memory T cell activation." [GOC:obol] is_a: GO:0050863 ! regulation of T cell activation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0035709 ! regulates memory T cell activation relationship: RO:0002211 GO:0035709 ! regulates memory T cell activation creation_date: 2011-04-03T09:10:06Z [Term] id: GO:2000568 name: positive regulation of memory T cell activation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of memory T cell activation." [GOC:obol] is_a: GO:0050870 ! positive regulation of T cell activation is_a: GO:2000567 ! regulation of memory T cell activation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0035709 ! positively regulates memory T cell activation relationship: RO:0002213 GO:0035709 ! positively regulates memory T cell activation creation_date: 2011-04-03T09:10:12Z [Term] id: GO:2000569 name: regulation of T-helper 2 cell activation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of T-helper 2 cell activation." [GOC:obol] synonym: "regulation of Th2 cell activation" EXACT [GOC:obol] is_a: GO:2000514 ! regulation of CD4-positive, alpha-beta T cell activation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0035712 ! regulates T-helper 2 cell activation relationship: RO:0002211 GO:0035712 ! regulates T-helper 2 cell activation creation_date: 2011-04-03T09:14:53Z [Term] id: GO:2000570 name: positive regulation of T-helper 2 cell activation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of T-helper 2 cell activation." [GOC:obol] synonym: "positive regulation of Th2 cell activation" EXACT [GOC:obol] is_a: GO:2000516 ! positive regulation of CD4-positive, alpha-beta T cell activation is_a: GO:2000569 ! regulation of T-helper 2 cell activation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0035712 ! positively regulates T-helper 2 cell activation relationship: RO:0002213 GO:0035712 ! positively regulates T-helper 2 cell activation creation_date: 2011-04-03T09:14:59Z [Term] id: GO:2000573 name: positive regulation of DNA biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of DNA biosynthetic process." [GOC:obol] synonym: "positive regulation of DNA anabolism" EXACT [GOC:obol] synonym: "positive regulation of DNA biosynthesis" EXACT [GOC:obol] synonym: "positive regulation of DNA formation" EXACT [GOC:obol] synonym: "positive regulation of DNA synthesis" EXACT [GOC:obol] is_a: GO:0010557 ! positive regulation of macromolecule biosynthetic process is_a: GO:0051054 ! positive regulation of DNA metabolic process is_a: GO:2000278 ! regulation of DNA biosynthetic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0071897 ! positively regulates DNA biosynthetic process relationship: RO:0002213 GO:0071897 ! positively regulates DNA biosynthetic process creation_date: 2011-04-04T10:01:20Z [Term] id: GO:2000595 name: regulation of optic nerve formation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of optic nerve formation." [GOC:obol] synonym: "regulation of CN II biosynthesis" RELATED [GOC:obol] synonym: "regulation of CN II formation" RELATED [GOC:obol] is_a: GO:0022603 ! regulation of anatomical structure morphogenesis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0021634 ! regulates optic nerve formation relationship: RO:0002211 GO:0021634 ! regulates optic nerve formation creation_date: 2011-04-11T03:41:30Z [Term] id: GO:2000596 name: negative regulation of optic nerve formation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of optic nerve formation." [GOC:obol] synonym: "negative regulation of CN II biosynthesis" RELATED [GOC:obol] synonym: "negative regulation of CN II formation" RELATED [GOC:obol] is_a: GO:0051093 ! negative regulation of developmental process is_a: GO:2000595 ! regulation of optic nerve formation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0021634 ! negatively regulates optic nerve formation relationship: RO:0002212 GO:0021634 ! negatively regulates optic nerve formation creation_date: 2011-04-11T03:41:35Z [Term] id: GO:2000597 name: positive regulation of optic nerve formation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of optic nerve formation." [GOC:obol] synonym: "positive regulation of CN II biosynthesis" RELATED [GOC:obol] synonym: "positive regulation of CN II formation" RELATED [GOC:obol] is_a: GO:0051094 ! positive regulation of developmental process is_a: GO:2000595 ! regulation of optic nerve formation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0021634 ! positively regulates optic nerve formation relationship: RO:0002213 GO:0021634 ! positively regulates optic nerve formation creation_date: 2011-04-11T03:41:39Z [Term] id: GO:2000606 name: regulation of cell proliferation involved in mesonephros development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cell proliferation involved in mesonephros development." [GOC:obol] is_a: GO:1901722 ! regulation of cell proliferation involved in kidney development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0061209 ! regulates cell proliferation involved in mesonephros development relationship: RO:0002211 GO:0061209 ! regulates cell proliferation involved in mesonephros development creation_date: 2011-04-18T08:42:19Z [Term] id: GO:2000607 name: negative regulation of cell proliferation involved in mesonephros development namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of cell proliferation involved in mesonephros development." [GOC:obol] is_a: GO:1901723 ! negative regulation of cell proliferation involved in kidney development is_a: GO:2000606 ! regulation of cell proliferation involved in mesonephros development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0061209 ! negatively regulates cell proliferation involved in mesonephros development relationship: RO:0002212 GO:0061209 ! negatively regulates cell proliferation involved in mesonephros development creation_date: 2011-04-18T08:42:23Z [Term] id: GO:2000608 name: positive regulation of cell proliferation involved in mesonephros development namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cell proliferation involved in mesonephros development." [GOC:obol] is_a: GO:1901724 ! positive regulation of cell proliferation involved in kidney development is_a: GO:2000606 ! regulation of cell proliferation involved in mesonephros development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0061209 ! positively regulates cell proliferation involved in mesonephros development relationship: RO:0002213 GO:0061209 ! positively regulates cell proliferation involved in mesonephros development creation_date: 2011-04-18T08:42:25Z [Term] id: GO:2000609 name: regulation of thyroid hormone generation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of thyroid hormone generation." [GOC:obol] is_a: GO:0032350 ! regulation of hormone metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0006590 ! regulates thyroid hormone generation relationship: RO:0002211 GO:0006590 ! regulates thyroid hormone generation property_value: RO:0002161 NCBITaxon:4895 creation_date: 2011-04-18T10:12:14Z [Term] id: GO:2000610 name: negative regulation of thyroid hormone generation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of thyroid hormone generation." [GOC:obol] is_a: GO:0032351 ! negative regulation of hormone metabolic process is_a: GO:2000609 ! regulation of thyroid hormone generation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0006590 ! negatively regulates thyroid hormone generation relationship: RO:0002212 GO:0006590 ! negatively regulates thyroid hormone generation property_value: RO:0002161 NCBITaxon:4895 creation_date: 2011-04-18T10:12:19Z [Term] id: GO:2000611 name: positive regulation of thyroid hormone generation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of thyroid hormone generation." [GOC:obol] is_a: GO:0032352 ! positive regulation of hormone metabolic process is_a: GO:2000609 ! regulation of thyroid hormone generation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0006590 ! positively regulates thyroid hormone generation relationship: RO:0002213 GO:0006590 ! positively regulates thyroid hormone generation property_value: RO:0002161 NCBITaxon:4895 creation_date: 2011-04-18T10:12:22Z [Term] id: GO:2000612 name: regulation of thyroid-stimulating hormone secretion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of thyroid-stimulating hormone secretion." [GOC:obol] synonym: "regulation of thyroid stimulating hormone secretion" EXACT [GOC:obol] synonym: "regulation of TSH secretion" EXACT [GOC:obol] is_a: GO:0090276 ! regulation of peptide hormone secretion intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0070460 ! regulates thyroid-stimulating hormone secretion relationship: RO:0002211 GO:0070460 ! regulates thyroid-stimulating hormone secretion creation_date: 2011-04-18T12:56:16Z [Term] id: GO:2000613 name: negative regulation of thyroid-stimulating hormone secretion namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of thyroid-stimulating hormone secretion." [GOC:obol] synonym: "negative regulation of thyroid stimulating hormone secretion" EXACT [GOC:obol] synonym: "negative regulation of TSH secretion" EXACT [GOC:obol] is_a: GO:0090278 ! negative regulation of peptide hormone secretion is_a: GO:2000612 ! regulation of thyroid-stimulating hormone secretion intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0070460 ! negatively regulates thyroid-stimulating hormone secretion relationship: RO:0002212 GO:0070460 ! negatively regulates thyroid-stimulating hormone secretion creation_date: 2011-04-18T12:56:20Z [Term] id: GO:2000614 name: positive regulation of thyroid-stimulating hormone secretion namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of thyroid-stimulating hormone secretion." [GOC:obol] synonym: "positive regulation of thyroid stimulating hormone secretion" EXACT [GOC:obol] synonym: "positive regulation of TSH secretion" EXACT [GOC:obol] is_a: GO:0090277 ! positive regulation of peptide hormone secretion is_a: GO:2000612 ! regulation of thyroid-stimulating hormone secretion intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0070460 ! positively regulates thyroid-stimulating hormone secretion relationship: RO:0002213 GO:0070460 ! positively regulates thyroid-stimulating hormone secretion creation_date: 2011-04-18T12:56:22Z [Term] id: GO:2000647 name: negative regulation of stem cell proliferation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of stem cell proliferation." [GOC:dph] is_a: GO:0008285 ! negative regulation of cell population proliferation is_a: GO:0072091 ! regulation of stem cell proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0072089 ! negatively regulates stem cell proliferation relationship: RO:0002212 GO:0072089 ! negatively regulates stem cell proliferation property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4751 creation_date: 2011-04-27T01:04:22Z [Term] id: GO:2000648 name: positive regulation of stem cell proliferation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of stem cell proliferation." [GOC:dph] is_a: GO:0008284 ! positive regulation of cell population proliferation is_a: GO:0072091 ! regulation of stem cell proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0072089 ! positively regulates stem cell proliferation relationship: RO:0002213 GO:0072089 ! positively regulates stem cell proliferation property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4751 creation_date: 2011-04-27T01:04:25Z [Term] id: GO:2000649 name: regulation of sodium ion transmembrane transporter activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of sodium ion transmembrane transporter activity." [GOC:obol] subset: gocheck_obsoletion_candidate synonym: "regulation of sodium transporter activity" EXACT [GOC:obol] is_a: GO:0022898 ! regulation of transmembrane transporter activity is_a: GO:1902305 ! regulation of sodium ion transmembrane transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0015081 ! regulates sodium ion transmembrane transporter activity relationship: RO:0002211 GO:0015081 ! regulates sodium ion transmembrane transporter activity creation_date: 2011-04-28T08:42:53Z [Term] id: GO:2000651 name: positive regulation of sodium ion transmembrane transporter activity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of sodium ion transmembrane transporter activity." [GOC:obol] subset: gocheck_obsoletion_candidate synonym: "positive regulation of sodium transporter activity" EXACT [GOC:obol] is_a: GO:0032414 ! positive regulation of ion transmembrane transporter activity is_a: GO:1902307 ! positive regulation of sodium ion transmembrane transport is_a: GO:2000649 ! regulation of sodium ion transmembrane transporter activity intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0015081 ! positively regulates sodium ion transmembrane transporter activity relationship: RO:0002213 GO:0015081 ! positively regulates sodium ion transmembrane transporter activity creation_date: 2011-04-28T08:43:00Z [Term] id: GO:2000654 name: regulation of cellular response to testosterone stimulus namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cellular response to testosterone stimulus." [GOC:BHF] is_a: GO:0048583 ! regulation of response to stimulus is_a: GO:0050794 ! regulation of cellular process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0071394 ! regulates cellular response to testosterone stimulus relationship: RO:0002211 GO:0071394 ! regulates cellular response to testosterone stimulus creation_date: 2011-05-02T03:23:56Z [Term] id: GO:2000655 name: negative regulation of cellular response to testosterone stimulus namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of cellular response to testosterone stimulus." [GOC:BHF] is_a: GO:0048523 ! negative regulation of cellular process is_a: GO:0048585 ! negative regulation of response to stimulus is_a: GO:2000654 ! regulation of cellular response to testosterone stimulus intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0071394 ! negatively regulates cellular response to testosterone stimulus relationship: RO:0002212 GO:0071394 ! negatively regulates cellular response to testosterone stimulus creation_date: 2011-05-02T03:23:59Z [Term] id: GO:2000668 name: regulation of dendritic cell apoptotic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of dendritic cell apoptotic process." [GOC:mtg_apoptosis, GOC:obol] synonym: "regulation of dendritic cell apoptosis" NARROW [] is_a: GO:2000106 ! regulation of leukocyte apoptotic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0097048 ! regulates dendritic cell apoptotic process relationship: RO:0002211 GO:0097048 ! regulates dendritic cell apoptotic process creation_date: 2011-05-09T07:34:16Z [Term] id: GO:2000669 name: negative regulation of dendritic cell apoptotic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of dendritic cell apoptotic process." [GOC:mtg_apoptosis, GOC:obol] synonym: "negative regulation of dendritic cell apoptosis" NARROW [] is_a: GO:2000107 ! negative regulation of leukocyte apoptotic process is_a: GO:2000668 ! regulation of dendritic cell apoptotic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0097048 ! negatively regulates dendritic cell apoptotic process relationship: RO:0002212 GO:0097048 ! negatively regulates dendritic cell apoptotic process creation_date: 2011-05-09T07:34:21Z [Term] id: GO:2000670 name: positive regulation of dendritic cell apoptotic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of dendritic cell apoptotic process." [GOC:mtg_apoptosis, GOC:obol] synonym: "positive regulation of dendritic cell apoptosis" NARROW [] is_a: GO:2000108 ! positive regulation of leukocyte apoptotic process is_a: GO:2000668 ! regulation of dendritic cell apoptotic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0097048 ! positively regulates dendritic cell apoptotic process relationship: RO:0002213 GO:0097048 ! positively regulates dendritic cell apoptotic process creation_date: 2011-05-09T07:34:26Z [Term] id: GO:2000671 name: regulation of motor neuron apoptotic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of motor neuron apoptotic process." [GOC:mtg_apoptosis, GOC:obol] synonym: "regulation of motoneuron apoptosis" EXACT [GOC:obol] synonym: "regulation of motor neuron apoptosis" NARROW [] is_a: GO:0043523 ! regulation of neuron apoptotic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0097049 ! regulates motor neuron apoptotic process relationship: RO:0002211 GO:0097049 ! regulates motor neuron apoptotic process property_value: RO:0002161 NCBITaxon:4896 creation_date: 2011-05-09T10:56:17Z [Term] id: GO:2000672 name: negative regulation of motor neuron apoptotic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of motor neuron apoptotic process." [GOC:mtg_apoptosis, GOC:obol] synonym: "negative regulation of motoneuron apoptosis" EXACT [GOC:obol] synonym: "negative regulation of motor neuron apoptosis" NARROW [] is_a: GO:0043524 ! negative regulation of neuron apoptotic process is_a: GO:2000671 ! regulation of motor neuron apoptotic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0097049 ! negatively regulates motor neuron apoptotic process relationship: RO:0002212 GO:0097049 ! negatively regulates motor neuron apoptotic process property_value: RO:0002161 NCBITaxon:4896 creation_date: 2011-05-09T10:56:21Z [Term] id: GO:2000673 name: positive regulation of motor neuron apoptotic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of motor neuron apoptotic process." [GOC:mtg_apoptosis, GOC:obol] synonym: "positive regulation of motoneuron apoptosis" EXACT [GOC:obol] synonym: "positive regulation of motor neuron apoptosis" NARROW [] is_a: GO:0043525 ! positive regulation of neuron apoptotic process is_a: GO:2000671 ! regulation of motor neuron apoptotic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0097049 ! positively regulates motor neuron apoptotic process relationship: RO:0002213 GO:0097049 ! positively regulates motor neuron apoptotic process property_value: RO:0002161 NCBITaxon:4896 creation_date: 2011-05-09T10:56:24Z [Term] id: GO:2000674 name: regulation of type B pancreatic cell apoptotic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of type B pancreatic cell apoptotic process." [GOC:mtg_apoptosis, GOC:obol] synonym: "regulation of pancreatic B cell apoptosis" EXACT [GOC:obol] synonym: "regulation of pancreatic beta cell apoptosis" EXACT [GOC:obol] synonym: "regulation of type B pancreatic cell apoptosis" NARROW [] is_a: GO:1904035 ! regulation of epithelial cell apoptotic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0097050 ! regulates type B pancreatic cell apoptotic process relationship: RO:0002211 GO:0097050 ! regulates type B pancreatic cell apoptotic process property_value: RO:0002161 NCBITaxon:4751 creation_date: 2011-05-09T11:51:09Z [Term] id: GO:2000675 name: negative regulation of type B pancreatic cell apoptotic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of type B pancreatic cell apoptotic process." [GOC:mtg_apoptosis, GOC:obol] synonym: "negative regulation of pancreatic B cell apoptosis" EXACT [GOC:obol] synonym: "negative regulation of pancreatic beta cell apoptosis" EXACT [GOC:obol] synonym: "negative regulation of type B pancreatic cell apoptosis" NARROW [] is_a: GO:1904036 ! negative regulation of epithelial cell apoptotic process is_a: GO:2000674 ! regulation of type B pancreatic cell apoptotic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0097050 ! negatively regulates type B pancreatic cell apoptotic process relationship: RO:0002212 GO:0097050 ! negatively regulates type B pancreatic cell apoptotic process property_value: RO:0002161 NCBITaxon:4751 creation_date: 2011-05-09T11:51:12Z [Term] id: GO:2000676 name: positive regulation of type B pancreatic cell apoptotic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of type B pancreatic cell apoptotic process." [GOC:mtg_apoptosis, GOC:obol] synonym: "positive regulation of pancreatic B cell apoptosis" EXACT [GOC:obol] synonym: "positive regulation of pancreatic beta cell apoptosis" EXACT [GOC:obol] synonym: "positive regulation of type B pancreatic cell apoptosis" NARROW [] is_a: GO:1904037 ! positive regulation of epithelial cell apoptotic process is_a: GO:2000674 ! regulation of type B pancreatic cell apoptotic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0097050 ! positively regulates type B pancreatic cell apoptotic process relationship: RO:0002213 GO:0097050 ! positively regulates type B pancreatic cell apoptotic process property_value: RO:0002161 NCBITaxon:4751 creation_date: 2011-05-09T11:51:15Z [Term] id: GO:2000690 name: regulation of cardiac muscle cell myoblast differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cardiac muscle cell myoblast differentiation." [GOC:obol] synonym: "regulation of cardiac myoblast differentiation" RELATED [GOC:obol] synonym: "regulation of myocardial precursor cell differentiation" EXACT [GOC:obol] is_a: GO:0045661 ! regulation of myoblast differentiation is_a: GO:0051890 ! regulation of cardioblast differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0060379 ! regulates cardiac muscle cell myoblast differentiation relationship: RO:0002211 GO:0060379 ! regulates cardiac muscle cell myoblast differentiation creation_date: 2011-05-25T09:08:01Z [Term] id: GO:2000691 name: negative regulation of cardiac muscle cell myoblast differentiation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of cardiac muscle cell myoblast differentiation." [GOC:obol] synonym: "negative regulation of cardiac myoblast differentiation" RELATED [GOC:obol] synonym: "negative regulation of myocardial precursor cell differentiation" EXACT [GOC:obol] is_a: GO:0045662 ! negative regulation of myoblast differentiation is_a: GO:0051892 ! negative regulation of cardioblast differentiation is_a: GO:2000690 ! regulation of cardiac muscle cell myoblast differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0060379 ! negatively regulates cardiac muscle cell myoblast differentiation relationship: RO:0002212 GO:0060379 ! negatively regulates cardiac muscle cell myoblast differentiation creation_date: 2011-05-25T09:08:06Z [Term] id: GO:2000696 name: regulation of epithelial cell differentiation involved in kidney development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of epithelial cell differentiation involved in kidney development." [GOC:mtg_kidney_jan10, GOC:yaf] is_a: GO:0030856 ! regulation of epithelial cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0035850 ! regulates epithelial cell differentiation involved in kidney development relationship: RO:0002211 GO:0035850 ! regulates epithelial cell differentiation involved in kidney development creation_date: 2011-05-16T04:23:52Z [Term] id: GO:2000697 name: negative regulation of epithelial cell differentiation involved in kidney development namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of epithelial cell differentiation involved in kidney development." [GOC:mtg_kidney_jan10, GOC:yaf] is_a: GO:0030857 ! negative regulation of epithelial cell differentiation is_a: GO:2000696 ! regulation of epithelial cell differentiation involved in kidney development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0035850 ! negatively regulates epithelial cell differentiation involved in kidney development relationship: RO:0002212 GO:0035850 ! negatively regulates epithelial cell differentiation involved in kidney development creation_date: 2011-05-16T04:23:55Z [Term] id: GO:2000698 name: positive regulation of epithelial cell differentiation involved in kidney development namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of epithelial cell differentiation involved in kidney development." [GOC:mtg_kidney_jan10, GOC:yaf] is_a: GO:0030858 ! positive regulation of epithelial cell differentiation is_a: GO:2000696 ! regulation of epithelial cell differentiation involved in kidney development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0035850 ! positively regulates epithelial cell differentiation involved in kidney development relationship: RO:0002213 GO:0035850 ! positively regulates epithelial cell differentiation involved in kidney development creation_date: 2011-05-16T04:23:57Z [Term] id: GO:2000700 name: positive regulation of cardiac muscle cell myoblast differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cardiac muscle cell myoblast differentiation." [GOC:obol] synonym: "positive regulation of cardiac myoblast differentiation" RELATED [GOC:obol] synonym: "positive regulation of myocardial precursor cell differentiation" EXACT [GOC:obol] is_a: GO:0045663 ! positive regulation of myoblast differentiation is_a: GO:0051891 ! positive regulation of cardioblast differentiation is_a: GO:2000690 ! regulation of cardiac muscle cell myoblast differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0060379 ! positively regulates cardiac muscle cell myoblast differentiation relationship: RO:0002213 GO:0060379 ! positively regulates cardiac muscle cell myoblast differentiation creation_date: 2011-05-25T09:08:09Z [Term] id: GO:2000725 name: regulation of cardiac muscle cell differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cardiac muscle cell differentiation." [GOC:BHF] synonym: "regulation of cardiomyocyte differentiation" EXACT [GOC:obol] synonym: "regulation of heart muscle cell differentiation" RELATED [GOC:obol] is_a: GO:0051153 ! regulation of striated muscle cell differentiation is_a: GO:1905207 ! regulation of cardiocyte differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0055007 ! regulates cardiac muscle cell differentiation relationship: RO:0002211 GO:0055007 ! regulates cardiac muscle cell differentiation creation_date: 2011-06-08T10:51:06Z [Term] id: GO:2000726 name: negative regulation of cardiac muscle cell differentiation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of cardiac muscle cell differentiation." [GOC:BHF] synonym: "negative regulation of cardiomyocyte differentiation" EXACT [GOC:obol] synonym: "negative regulation of heart muscle cell differentiation" RELATED [GOC:obol] is_a: GO:0051154 ! negative regulation of striated muscle cell differentiation is_a: GO:1905208 ! negative regulation of cardiocyte differentiation is_a: GO:2000725 ! regulation of cardiac muscle cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0055007 ! negatively regulates cardiac muscle cell differentiation relationship: RO:0002212 GO:0055007 ! negatively regulates cardiac muscle cell differentiation creation_date: 2011-06-08T10:51:11Z [Term] id: GO:2000727 name: positive regulation of cardiac muscle cell differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cardiac muscle cell differentiation." [GOC:BHF] synonym: "positive regulation of cardiomyocyte differentiation" EXACT [GOC:obol] synonym: "positive regulation of heart muscle cell differentiation" RELATED [GOC:obol] is_a: GO:0051155 ! positive regulation of striated muscle cell differentiation is_a: GO:1905209 ! positive regulation of cardiocyte differentiation is_a: GO:2000725 ! regulation of cardiac muscle cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0055007 ! positively regulates cardiac muscle cell differentiation relationship: RO:0002213 GO:0055007 ! positively regulates cardiac muscle cell differentiation creation_date: 2011-06-08T10:51:15Z [Term] id: GO:2000729 name: positive regulation of mesenchymal cell proliferation involved in ureter development namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of mesenchymal cell proliferation involved in ureter development." [GOC:obol] synonym: "positive regulation of ureter mesenchymal cell proliferation" RELATED [GOC:obol] synonym: "positive regulation of ureteral mesenchymal cell proliferation" RELATED [GOC:obol] is_a: GO:0002053 ! positive regulation of mesenchymal cell proliferation is_a: GO:0051094 ! positive regulation of developmental process is_a: GO:0072199 ! regulation of mesenchymal cell proliferation involved in ureter development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0072198 ! positively regulates mesenchymal cell proliferation involved in ureter development relationship: RO:0002213 GO:0072198 ! positively regulates mesenchymal cell proliferation involved in ureter development creation_date: 2011-06-10T02:27:19Z [Term] id: GO:2000736 name: regulation of stem cell differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of stem cell differentiation." [GOC:obol] is_a: GO:0045595 ! regulation of cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0048863 ! regulates stem cell differentiation relationship: RO:0002211 GO:0048863 ! regulates stem cell differentiation creation_date: 2011-06-14T02:05:16Z [Term] id: GO:2000737 name: negative regulation of stem cell differentiation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of stem cell differentiation." [GOC:obol] is_a: GO:0045596 ! negative regulation of cell differentiation is_a: GO:2000736 ! regulation of stem cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0048863 ! negatively regulates stem cell differentiation relationship: RO:0002212 GO:0048863 ! negatively regulates stem cell differentiation creation_date: 2011-06-14T02:05:20Z [Term] id: GO:2000738 name: positive regulation of stem cell differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of stem cell differentiation." [GOC:obol] is_a: GO:0045597 ! positive regulation of cell differentiation is_a: GO:2000736 ! regulation of stem cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0048863 ! positively regulates stem cell differentiation relationship: RO:0002213 GO:0048863 ! positively regulates stem cell differentiation creation_date: 2011-06-14T02:05:23Z [Term] id: GO:2000739 name: regulation of mesenchymal stem cell differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of mesenchymal stem cell differentiation." [GOC:obol] is_a: GO:2000736 ! regulation of stem cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0072497 ! regulates mesenchymal stem cell differentiation relationship: RO:0002211 GO:0072497 ! regulates mesenchymal stem cell differentiation creation_date: 2011-06-14T02:31:27Z [Term] id: GO:2000740 name: negative regulation of mesenchymal stem cell differentiation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of mesenchymal stem cell differentiation." [GOC:obol] is_a: GO:2000737 ! negative regulation of stem cell differentiation is_a: GO:2000739 ! regulation of mesenchymal stem cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0072497 ! negatively regulates mesenchymal stem cell differentiation relationship: RO:0002212 GO:0072497 ! negatively regulates mesenchymal stem cell differentiation creation_date: 2011-06-14T02:31:31Z [Term] id: GO:2000741 name: positive regulation of mesenchymal stem cell differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of mesenchymal stem cell differentiation." [GOC:obol] is_a: GO:2000738 ! positive regulation of stem cell differentiation is_a: GO:2000739 ! regulation of mesenchymal stem cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0072497 ! positively regulates mesenchymal stem cell differentiation relationship: RO:0002213 GO:0072497 ! positively regulates mesenchymal stem cell differentiation creation_date: 2011-06-14T02:31:34Z [Term] id: GO:2000765 name: regulation of cytoplasmic translation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cytoplasmic translation." [GOC:obol] is_a: GO:0006417 ! regulation of translation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0002181 ! regulates cytoplasmic translation relationship: RO:0002211 GO:0002181 ! regulates cytoplasmic translation creation_date: 2011-06-20T10:39:19Z [Term] id: GO:2000766 name: negative regulation of cytoplasmic translation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of cytoplasmic translation." [GOC:obol] is_a: GO:0017148 ! negative regulation of translation is_a: GO:2000765 ! regulation of cytoplasmic translation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0002181 ! negatively regulates cytoplasmic translation relationship: RO:0002212 GO:0002181 ! negatively regulates cytoplasmic translation creation_date: 2011-06-20T10:39:23Z [Term] id: GO:2000767 name: positive regulation of cytoplasmic translation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cytoplasmic translation." [GOC:obol] is_a: GO:0045727 ! positive regulation of translation is_a: GO:2000765 ! regulation of cytoplasmic translation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0002181 ! positively regulates cytoplasmic translation relationship: RO:0002213 GO:0002181 ! positively regulates cytoplasmic translation creation_date: 2011-06-20T10:39:26Z [Term] id: GO:2000768 name: positive regulation of nephron tubule epithelial cell differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of nephron tubule epithelial cell differentiation." [GOC:obol] is_a: GO:0072182 ! regulation of nephron tubule epithelial cell differentiation is_a: GO:2000698 ! positive regulation of epithelial cell differentiation involved in kidney development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0072160 ! positively regulates nephron tubule epithelial cell differentiation relationship: RO:0002213 GO:0072160 ! positively regulates nephron tubule epithelial cell differentiation creation_date: 2011-06-22T11:55:06Z [Term] id: GO:2000790 name: regulation of mesenchymal cell proliferation involved in lung development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of mesenchymal cell proliferation involved in lung development." [PMID:21513708] is_a: GO:0010464 ! regulation of mesenchymal cell proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0060916 ! regulates mesenchymal cell proliferation involved in lung development relationship: RO:0002211 GO:0060916 ! regulates mesenchymal cell proliferation involved in lung development creation_date: 2011-06-24T01:53:50Z [Term] id: GO:2000791 name: negative regulation of mesenchymal cell proliferation involved in lung development namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of mesenchymal cell proliferation involved in lung development." [PMID:21513708] is_a: GO:0051093 ! negative regulation of developmental process is_a: GO:0051241 ! negative regulation of multicellular organismal process is_a: GO:0072201 ! negative regulation of mesenchymal cell proliferation is_a: GO:2000790 ! regulation of mesenchymal cell proliferation involved in lung development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0060916 ! negatively regulates mesenchymal cell proliferation involved in lung development relationship: RO:0002212 GO:0060916 ! negatively regulates mesenchymal cell proliferation involved in lung development creation_date: 2011-06-24T01:53:53Z [Term] id: GO:2000792 name: positive regulation of mesenchymal cell proliferation involved in lung development namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of mesenchymal cell proliferation involved in lung development." [PMID:21513708] is_a: GO:0002053 ! positive regulation of mesenchymal cell proliferation is_a: GO:0051094 ! positive regulation of developmental process is_a: GO:0051240 ! positive regulation of multicellular organismal process is_a: GO:2000790 ! regulation of mesenchymal cell proliferation involved in lung development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0060916 ! positively regulates mesenchymal cell proliferation involved in lung development relationship: RO:0002213 GO:0060916 ! positively regulates mesenchymal cell proliferation involved in lung development creation_date: 2011-06-24T01:53:56Z [Term] id: GO:2000793 name: cell proliferation involved in heart valve development namespace: biological_process def: "Any cell proliferation that is involved in heart valve development." [GOC:BHF] synonym: "cell proliferation of cardiac valve development" EXACT [GOC:obol] synonym: "cell proliferation of heart valve development" EXACT [GOC:obol] is_a: GO:0008283 ! cell population proliferation intersection_of: GO:0008283 ! cell population proliferation intersection_of: BFO:0000050 GO:0003170 ! part of heart valve development relationship: BFO:0000050 GO:0003170 ! part of heart valve development creation_date: 2011-06-24T03:12:15Z [Term] id: GO:2000794 name: regulation of epithelial cell proliferation involved in lung morphogenesis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of epithelial cell proliferation involved in lung morphogenesis." [PMID:21513708] is_a: GO:0050678 ! regulation of epithelial cell proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0060502 ! regulates epithelial cell proliferation involved in lung morphogenesis relationship: RO:0002211 GO:0060502 ! regulates epithelial cell proliferation involved in lung morphogenesis creation_date: 2011-06-25T07:22:38Z [Term] id: GO:2000795 name: negative regulation of epithelial cell proliferation involved in lung morphogenesis namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of epithelial cell proliferation involved in lung morphogenesis." [PMID:21513708] is_a: GO:0050680 ! negative regulation of epithelial cell proliferation is_a: GO:2000794 ! regulation of epithelial cell proliferation involved in lung morphogenesis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0060502 ! negatively regulates epithelial cell proliferation involved in lung morphogenesis relationship: RO:0002212 GO:0060502 ! negatively regulates epithelial cell proliferation involved in lung morphogenesis creation_date: 2011-06-25T07:22:42Z [Term] id: GO:2000797 name: regulation of amniotic stem cell differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of amniotic stem cell differentiation." [GOC:obol] is_a: GO:2000739 ! regulation of mesenchymal stem cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0097086 ! regulates amniotic stem cell differentiation relationship: RO:0002211 GO:0097086 ! regulates amniotic stem cell differentiation creation_date: 2011-06-29T02:18:59Z [Term] id: GO:2000798 name: negative regulation of amniotic stem cell differentiation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of amniotic stem cell differentiation." [GOC:obol] is_a: GO:2000740 ! negative regulation of mesenchymal stem cell differentiation is_a: GO:2000797 ! regulation of amniotic stem cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0097086 ! negatively regulates amniotic stem cell differentiation relationship: RO:0002212 GO:0097086 ! negatively regulates amniotic stem cell differentiation creation_date: 2011-06-29T02:19:03Z [Term] id: GO:2000799 name: positive regulation of amniotic stem cell differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of amniotic stem cell differentiation." [GOC:obol] is_a: GO:2000741 ! positive regulation of mesenchymal stem cell differentiation is_a: GO:2000797 ! regulation of amniotic stem cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0097086 ! positively regulates amniotic stem cell differentiation relationship: RO:0002213 GO:0097086 ! positively regulates amniotic stem cell differentiation creation_date: 2011-06-29T02:19:06Z [Term] id: GO:2000810 name: regulation of bicellular tight junction assembly namespace: biological_process def: "Any process that modulates the frequency, rate or extent of tight junction assembly." [GOC:BHF] synonym: "regulation of tight junction formation" EXACT [GOC:obol] xref: Reactome:R-HSA-8935964 "RUNX1 regulates expression of components of tight junctions" is_a: GO:1901888 ! regulation of cell junction assembly intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0070830 ! regulates bicellular tight junction assembly relationship: RO:0002211 GO:0070830 ! regulates bicellular tight junction assembly property_value: RO:0002161 NCBITaxon:4751 creation_date: 2011-07-06T01:08:28Z [Term] id: GO:2000818 name: negative regulation of myoblast proliferation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of myoblast proliferation." [GOC:obol] is_a: GO:0008285 ! negative regulation of cell population proliferation is_a: GO:2000291 ! regulation of myoblast proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0051450 ! negatively regulates myoblast proliferation relationship: RO:0002212 GO:0051450 ! negatively regulates myoblast proliferation property_value: RO:0002161 NCBITaxon:4751 creation_date: 2011-07-12T03:06:04Z [Term] id: GO:2000826 name: regulation of heart morphogenesis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of heart morphogenesis." [GOC:BHF] synonym: "regulation of cardiac morphogenesis" RELATED [GOC:obol] is_a: GO:2000027 ! regulation of animal organ morphogenesis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0003007 ! regulates heart morphogenesis relationship: RO:0002211 GO:0003007 ! regulates heart morphogenesis creation_date: 2011-07-19T10:08:58Z [Term] id: GO:2000828 name: regulation of parathyroid hormone secretion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of parathyroid hormone secretion." [GOC:obol] synonym: "regulation of parathormone secretion" EXACT [GOC:obol] synonym: "regulation of parathyrin secretion" EXACT [GOC:obol] synonym: "regulation of PTH secretion" EXACT [GOC:obol] is_a: GO:0044060 ! regulation of endocrine process is_a: GO:0046883 ! regulation of hormone secretion intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0035898 ! regulates parathyroid hormone secretion relationship: RO:0002211 GO:0035898 ! regulates parathyroid hormone secretion property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 creation_date: 2011-07-26T08:37:53Z [Term] id: GO:2000829 name: negative regulation of parathyroid hormone secretion namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of parathyroid hormone secretion." [GOC:obol] synonym: "negative regulation of parathormone secretion" EXACT [GOC:obol] synonym: "negative regulation of parathyrin secretion" EXACT [GOC:obol] synonym: "negative regulation of PTH secretion" EXACT [GOC:obol] is_a: GO:0046888 ! negative regulation of hormone secretion is_a: GO:0051241 ! negative regulation of multicellular organismal process is_a: GO:2000828 ! regulation of parathyroid hormone secretion intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0035898 ! negatively regulates parathyroid hormone secretion relationship: RO:0002212 GO:0035898 ! negatively regulates parathyroid hormone secretion property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 creation_date: 2011-07-26T08:37:57Z [Term] id: GO:2000830 name: positive regulation of parathyroid hormone secretion namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of parathyroid hormone secretion." [GOC:obol] synonym: "positive regulation of parathormone secretion" EXACT [GOC:obol] synonym: "positive regulation of parathyrin secretion" EXACT [GOC:obol] synonym: "positive regulation of PTH secretion" EXACT [GOC:obol] is_a: GO:0046887 ! positive regulation of hormone secretion is_a: GO:0051240 ! positive regulation of multicellular organismal process is_a: GO:2000828 ! regulation of parathyroid hormone secretion intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0035898 ! positively regulates parathyroid hormone secretion relationship: RO:0002213 GO:0035898 ! positively regulates parathyroid hormone secretion property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 creation_date: 2011-07-26T08:38:00Z [Term] id: GO:2000831 name: regulation of steroid hormone secretion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of steroid hormone secretion." [GOC:sl] is_a: GO:0032368 ! regulation of lipid transport is_a: GO:0044060 ! regulation of endocrine process is_a: GO:0046883 ! regulation of hormone secretion intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0035929 ! regulates steroid hormone secretion relationship: RO:0002211 GO:0035929 ! regulates steroid hormone secretion property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 creation_date: 2011-07-26T08:38:46Z [Term] id: GO:2000832 name: negative regulation of steroid hormone secretion namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of steroid hormone secretion." [GOC:sl] is_a: GO:0032369 ! negative regulation of lipid transport is_a: GO:0046888 ! negative regulation of hormone secretion is_a: GO:0051241 ! negative regulation of multicellular organismal process is_a: GO:2000831 ! regulation of steroid hormone secretion intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0035929 ! negatively regulates steroid hormone secretion relationship: RO:0002212 GO:0035929 ! negatively regulates steroid hormone secretion property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 creation_date: 2011-07-26T08:38:50Z [Term] id: GO:2000833 name: positive regulation of steroid hormone secretion namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of steroid hormone secretion." [GOC:sl] is_a: GO:0032370 ! positive regulation of lipid transport is_a: GO:0046887 ! positive regulation of hormone secretion is_a: GO:0051240 ! positive regulation of multicellular organismal process is_a: GO:2000831 ! regulation of steroid hormone secretion intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0035929 ! positively regulates steroid hormone secretion relationship: RO:0002213 GO:0035929 ! positively regulates steroid hormone secretion property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 creation_date: 2011-07-26T08:38:51Z [Term] id: GO:2000834 name: regulation of androgen secretion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of androgen secretion." [GOC:sl] is_a: GO:2000831 ! regulation of steroid hormone secretion intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0035935 ! regulates androgen secretion relationship: RO:0002211 GO:0035935 ! regulates androgen secretion property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 creation_date: 2011-07-26T08:39:45Z [Term] id: GO:2000835 name: negative regulation of androgen secretion namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of androgen secretion." [GOC:sl] is_a: GO:2000832 ! negative regulation of steroid hormone secretion is_a: GO:2000834 ! regulation of androgen secretion intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0035935 ! negatively regulates androgen secretion relationship: RO:0002212 GO:0035935 ! negatively regulates androgen secretion property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 creation_date: 2011-07-26T08:39:48Z [Term] id: GO:2000836 name: positive regulation of androgen secretion namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of androgen secretion." [GOC:sl] is_a: GO:2000833 ! positive regulation of steroid hormone secretion is_a: GO:2000834 ! regulation of androgen secretion intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0035935 ! positively regulates androgen secretion relationship: RO:0002213 GO:0035935 ! positively regulates androgen secretion property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 creation_date: 2011-07-26T08:39:51Z [Term] id: GO:2000843 name: regulation of testosterone secretion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of testosterone secretion." [GOC:sl] is_a: GO:0032368 ! regulation of lipid transport is_a: GO:0046883 ! regulation of hormone secretion intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0035936 ! regulates testosterone secretion relationship: RO:0002211 GO:0035936 ! regulates testosterone secretion creation_date: 2011-07-26T08:42:29Z [Term] id: GO:2000844 name: negative regulation of testosterone secretion namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of testosterone secretion." [GOC:sl] is_a: GO:0032369 ! negative regulation of lipid transport is_a: GO:0046888 ! negative regulation of hormone secretion is_a: GO:2000843 ! regulation of testosterone secretion intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0035936 ! negatively regulates testosterone secretion relationship: RO:0002212 GO:0035936 ! negatively regulates testosterone secretion creation_date: 2011-07-26T08:42:33Z [Term] id: GO:2000845 name: positive regulation of testosterone secretion namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of testosterone secretion." [GOC:sl] is_a: GO:0032370 ! positive regulation of lipid transport is_a: GO:0046887 ! positive regulation of hormone secretion is_a: GO:2000843 ! regulation of testosterone secretion intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0035936 ! positively regulates testosterone secretion relationship: RO:0002213 GO:0035936 ! positively regulates testosterone secretion creation_date: 2011-07-26T08:42:36Z [Term] id: GO:2000846 name: regulation of corticosteroid hormone secretion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of corticosteroid hormone secretion." [GOC:sl] synonym: "regulation of corticosteroid secretion" RELATED [GOC:obol] is_a: GO:2000831 ! regulation of steroid hormone secretion intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0035930 ! regulates corticosteroid hormone secretion relationship: RO:0002211 GO:0035930 ! regulates corticosteroid hormone secretion property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 creation_date: 2011-07-26T08:43:38Z [Term] id: GO:2000847 name: negative regulation of corticosteroid hormone secretion namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of corticosteroid hormone secretion." [GOC:sl] synonym: "negative regulation of corticosteroid secretion" RELATED [GOC:obol] is_a: GO:2000832 ! negative regulation of steroid hormone secretion is_a: GO:2000846 ! regulation of corticosteroid hormone secretion intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0035930 ! negatively regulates corticosteroid hormone secretion relationship: RO:0002212 GO:0035930 ! negatively regulates corticosteroid hormone secretion property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 creation_date: 2011-07-26T08:43:42Z [Term] id: GO:2000848 name: positive regulation of corticosteroid hormone secretion namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of corticosteroid hormone secretion." [GOC:sl] synonym: "positive regulation of corticosteroid secretion" RELATED [GOC:obol] is_a: GO:2000833 ! positive regulation of steroid hormone secretion is_a: GO:2000846 ! regulation of corticosteroid hormone secretion intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0035930 ! positively regulates corticosteroid hormone secretion relationship: RO:0002213 GO:0035930 ! positively regulates corticosteroid hormone secretion property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 creation_date: 2011-07-26T08:43:45Z [Term] id: GO:2000849 name: regulation of glucocorticoid secretion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of glucocorticoid secretion." [GOC:sl] is_a: GO:2000846 ! regulation of corticosteroid hormone secretion intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0035933 ! regulates glucocorticoid secretion relationship: RO:0002211 GO:0035933 ! regulates glucocorticoid secretion property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 creation_date: 2011-07-26T08:44:43Z [Term] id: GO:2000850 name: negative regulation of glucocorticoid secretion namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of glucocorticoid secretion." [GOC:sl] is_a: GO:2000847 ! negative regulation of corticosteroid hormone secretion is_a: GO:2000849 ! regulation of glucocorticoid secretion intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0035933 ! negatively regulates glucocorticoid secretion relationship: RO:0002212 GO:0035933 ! negatively regulates glucocorticoid secretion property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 creation_date: 2011-07-26T08:44:48Z [Term] id: GO:2000851 name: positive regulation of glucocorticoid secretion namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of glucocorticoid secretion." [GOC:sl] is_a: GO:2000848 ! positive regulation of corticosteroid hormone secretion is_a: GO:2000849 ! regulation of glucocorticoid secretion intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0035933 ! positively regulates glucocorticoid secretion relationship: RO:0002213 GO:0035933 ! positively regulates glucocorticoid secretion property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 creation_date: 2011-07-26T08:44:51Z [Term] id: GO:2000855 name: regulation of mineralocorticoid secretion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of mineralocorticoid secretion." [GOC:sl] is_a: GO:2000846 ! regulation of corticosteroid hormone secretion intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0035931 ! regulates mineralocorticoid secretion relationship: RO:0002211 GO:0035931 ! regulates mineralocorticoid secretion property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 creation_date: 2011-07-26T08:46:38Z [Term] id: GO:2000856 name: negative regulation of mineralocorticoid secretion namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of mineralocorticoid secretion." [GOC:sl] is_a: GO:2000847 ! negative regulation of corticosteroid hormone secretion is_a: GO:2000855 ! regulation of mineralocorticoid secretion intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0035931 ! negatively regulates mineralocorticoid secretion relationship: RO:0002212 GO:0035931 ! negatively regulates mineralocorticoid secretion property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 creation_date: 2011-07-26T08:46:42Z [Term] id: GO:2000857 name: positive regulation of mineralocorticoid secretion namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of mineralocorticoid secretion." [GOC:sl] is_a: GO:2000848 ! positive regulation of corticosteroid hormone secretion is_a: GO:2000855 ! regulation of mineralocorticoid secretion intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0035931 ! positively regulates mineralocorticoid secretion relationship: RO:0002213 GO:0035931 ! positively regulates mineralocorticoid secretion property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 creation_date: 2011-07-26T08:46:45Z [Term] id: GO:2000858 name: regulation of aldosterone secretion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of aldosterone secretion." [GOC:sl] is_a: GO:2000855 ! regulation of mineralocorticoid secretion intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0035932 ! regulates aldosterone secretion relationship: RO:0002211 GO:0035932 ! regulates aldosterone secretion property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 creation_date: 2011-07-26T08:47:27Z [Term] id: GO:2000859 name: negative regulation of aldosterone secretion namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of aldosterone secretion." [GOC:sl] is_a: GO:2000856 ! negative regulation of mineralocorticoid secretion is_a: GO:2000858 ! regulation of aldosterone secretion intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0035932 ! negatively regulates aldosterone secretion relationship: RO:0002212 GO:0035932 ! negatively regulates aldosterone secretion property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 creation_date: 2011-07-26T08:47:31Z [Term] id: GO:2000860 name: positive regulation of aldosterone secretion namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of aldosterone secretion." [GOC:sl] is_a: GO:2000857 ! positive regulation of mineralocorticoid secretion is_a: GO:2000858 ! regulation of aldosterone secretion intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0035932 ! positively regulates aldosterone secretion relationship: RO:0002213 GO:0035932 ! positively regulates aldosterone secretion property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 creation_date: 2011-07-26T08:47:34Z [Term] id: GO:2000864 name: regulation of estradiol secretion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of estradiol secretion." [GOC:sl] synonym: "regulation of oestradiol secretion" EXACT [GOC:obol] is_a: GO:2000831 ! regulation of steroid hormone secretion intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0035938 ! regulates estradiol secretion relationship: RO:0002211 GO:0035938 ! regulates estradiol secretion property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 creation_date: 2011-07-26T08:49:13Z [Term] id: GO:2000865 name: negative regulation of estradiol secretion namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of estradiol secretion." [GOC:sl] synonym: "negative regulation of oestradiol secretion" EXACT [GOC:obol] is_a: GO:2000832 ! negative regulation of steroid hormone secretion is_a: GO:2000864 ! regulation of estradiol secretion intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0035938 ! negatively regulates estradiol secretion relationship: RO:0002212 GO:0035938 ! negatively regulates estradiol secretion property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 creation_date: 2011-07-26T08:49:17Z [Term] id: GO:2000866 name: positive regulation of estradiol secretion namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of estradiol secretion." [GOC:sl] synonym: "positive regulation of oestradiol secretion" EXACT [GOC:obol] is_a: GO:2000833 ! positive regulation of steroid hormone secretion is_a: GO:2000864 ! regulation of estradiol secretion intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0035938 ! positively regulates estradiol secretion relationship: RO:0002213 GO:0035938 ! positively regulates estradiol secretion property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 creation_date: 2011-07-26T08:49:20Z [Term] id: GO:2000870 name: regulation of progesterone secretion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of progesterone secretion." [GOC:sl] is_a: GO:2000194 ! regulation of female gonad development is_a: GO:2000831 ! regulation of steroid hormone secretion intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0042701 ! regulates progesterone secretion relationship: RO:0002211 GO:0042701 ! regulates progesterone secretion creation_date: 2011-07-26T08:51:14Z [Term] id: GO:2000871 name: negative regulation of progesterone secretion namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of progesterone secretion." [GOC:sl] is_a: GO:2000195 ! negative regulation of female gonad development is_a: GO:2000832 ! negative regulation of steroid hormone secretion is_a: GO:2000870 ! regulation of progesterone secretion intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0042701 ! negatively regulates progesterone secretion relationship: RO:0002212 GO:0042701 ! negatively regulates progesterone secretion creation_date: 2011-07-26T08:51:19Z [Term] id: GO:2000872 name: positive regulation of progesterone secretion namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of progesterone secretion." [GOC:sl] is_a: GO:2000196 ! positive regulation of female gonad development is_a: GO:2000833 ! positive regulation of steroid hormone secretion is_a: GO:2000870 ! regulation of progesterone secretion intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0042701 ! positively regulates progesterone secretion relationship: RO:0002213 GO:0042701 ! positively regulates progesterone secretion creation_date: 2011-07-26T08:51:22Z [Term] id: GO:2000881 name: regulation of starch catabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of starch catabolic process." [GOC:obol] synonym: "regulation of starch breakdown" EXACT [GOC:obol] synonym: "regulation of starch catabolism" EXACT [GOC:obol] synonym: "regulation of starch degradation" EXACT [GOC:obol] is_a: GO:0043470 ! regulation of carbohydrate catabolic process is_a: GO:2000904 ! regulation of starch metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0005983 ! regulates starch catabolic process relationship: RO:0002211 GO:0005983 ! regulates starch catabolic process creation_date: 2011-07-27T03:23:39Z [Term] id: GO:2000882 name: negative regulation of starch catabolic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of starch catabolic process." [GOC:obol] synonym: "negative regulation of starch breakdown" EXACT [GOC:obol] synonym: "negative regulation of starch catabolism" EXACT [GOC:obol] synonym: "negative regulation of starch degradation" EXACT [GOC:obol] is_a: GO:0009895 ! negative regulation of catabolic process is_a: GO:0010605 ! negative regulation of macromolecule metabolic process is_a: GO:0045912 ! negative regulation of carbohydrate metabolic process is_a: GO:2000881 ! regulation of starch catabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0005983 ! negatively regulates starch catabolic process relationship: RO:0002212 GO:0005983 ! negatively regulates starch catabolic process creation_date: 2011-07-27T03:23:46Z [Term] id: GO:2000883 name: positive regulation of starch catabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of starch catabolic process." [GOC:obol] synonym: "positive regulation of starch breakdown" EXACT [GOC:obol] synonym: "positive regulation of starch catabolism" EXACT [GOC:obol] synonym: "positive regulation of starch degradation" EXACT [GOC:obol] is_a: GO:0009896 ! positive regulation of catabolic process is_a: GO:0010604 ! positive regulation of macromolecule metabolic process is_a: GO:0045913 ! positive regulation of carbohydrate metabolic process is_a: GO:2000881 ! regulation of starch catabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0005983 ! positively regulates starch catabolic process relationship: RO:0002213 GO:0005983 ! positively regulates starch catabolic process creation_date: 2011-07-27T03:23:51Z [Term] id: GO:2000904 name: regulation of starch metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of starch metabolic process." [GOC:obol] synonym: "regulation of starch metabolism" EXACT [GOC:obol] is_a: GO:0032881 ! regulation of polysaccharide metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0005982 ! regulates starch metabolic process relationship: RO:0002211 GO:0005982 ! regulates starch metabolic process creation_date: 2011-07-28T11:33:13Z [Term] id: GO:2000973 name: regulation of pro-B cell differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of pro-B cell differentiation." [GOC:obol] synonym: "regulation of pro-B cell development" RELATED [GOC:obol] synonym: "regulation of pro-B lymphocyte differentiation" EXACT [GOC:obol] is_a: GO:1905456 ! regulation of lymphoid progenitor cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0002328 ! regulates pro-B cell differentiation relationship: RO:0002211 GO:0002328 ! regulates pro-B cell differentiation creation_date: 2011-08-02T03:05:45Z [Term] id: GO:2000974 name: negative regulation of pro-B cell differentiation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of pro-B cell differentiation." [GOC:obol] synonym: "negative regulation of pro-B cell development" RELATED [GOC:obol] synonym: "negative regulation of pro-B lymphocyte differentiation" EXACT [GOC:obol] is_a: GO:1905457 ! negative regulation of lymphoid progenitor cell differentiation is_a: GO:2000973 ! regulation of pro-B cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0002328 ! negatively regulates pro-B cell differentiation relationship: RO:0002212 GO:0002328 ! negatively regulates pro-B cell differentiation creation_date: 2011-08-02T03:05:50Z [Term] id: GO:2000975 name: positive regulation of pro-B cell differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of pro-B cell differentiation." [GOC:obol] synonym: "positive regulation of pro-B cell development" RELATED [GOC:obol] synonym: "positive regulation of pro-B lymphocyte differentiation" EXACT [GOC:obol] is_a: GO:1905458 ! positive regulation of lymphoid progenitor cell differentiation is_a: GO:2000973 ! regulation of pro-B cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0002328 ! positively regulates pro-B cell differentiation relationship: RO:0002213 GO:0002328 ! positively regulates pro-B cell differentiation creation_date: 2011-08-02T03:05:53Z [Term] id: GO:2000977 name: regulation of forebrain neuron differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of forebrain neuron differentiation." [GOC:obol] is_a: GO:0045664 ! regulation of neuron differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0021879 ! regulates forebrain neuron differentiation relationship: RO:0002211 GO:0021879 ! regulates forebrain neuron differentiation creation_date: 2011-08-03T12:09:12Z [Term] id: GO:2000978 name: negative regulation of forebrain neuron differentiation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of forebrain neuron differentiation." [GOC:obol] is_a: GO:0045665 ! negative regulation of neuron differentiation is_a: GO:2000977 ! regulation of forebrain neuron differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0021879 ! negatively regulates forebrain neuron differentiation relationship: RO:0002212 GO:0021879 ! negatively regulates forebrain neuron differentiation creation_date: 2011-08-03T12:09:16Z [Term] id: GO:2000979 name: positive regulation of forebrain neuron differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of forebrain neuron differentiation." [GOC:obol] is_a: GO:0045666 ! positive regulation of neuron differentiation is_a: GO:2000977 ! regulation of forebrain neuron differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0021879 ! positively regulates forebrain neuron differentiation relationship: RO:0002213 GO:0021879 ! positively regulates forebrain neuron differentiation creation_date: 2011-08-03T12:09:19Z [Term] id: GO:2000980 name: regulation of inner ear receptor cell differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of inner ear receptor cell differentiation." [GOC:obol] synonym: "regulation of inner ear hair cell differentiation" EXACT [GOC:obol] is_a: GO:0045631 ! regulation of mechanoreceptor differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0060113 ! regulates inner ear receptor cell differentiation relationship: RO:0002211 GO:0060113 ! regulates inner ear receptor cell differentiation creation_date: 2011-08-03T02:38:43Z [Term] id: GO:2000981 name: negative regulation of inner ear receptor cell differentiation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of inner ear receptor cell differentiation." [GOC:obol] synonym: "negative regulation of inner ear hair cell differentiation" EXACT [GOC:obol] is_a: GO:0045632 ! negative regulation of mechanoreceptor differentiation is_a: GO:2000980 ! regulation of inner ear receptor cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0060113 ! negatively regulates inner ear receptor cell differentiation relationship: RO:0002212 GO:0060113 ! negatively regulates inner ear receptor cell differentiation creation_date: 2011-08-03T02:38:47Z [Term] id: GO:2000982 name: positive regulation of inner ear receptor cell differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of inner ear receptor cell differentiation." [GOC:obol] synonym: "positive regulation of inner ear hair cell differentiation" EXACT [GOC:obol] is_a: GO:0045633 ! positive regulation of mechanoreceptor differentiation is_a: GO:2000980 ! regulation of inner ear receptor cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0060113 ! positively regulates inner ear receptor cell differentiation relationship: RO:0002213 GO:0060113 ! positively regulates inner ear receptor cell differentiation creation_date: 2011-08-03T02:38:51Z [Term] id: GO:2001012 name: mesenchymal cell differentiation involved in renal system development namespace: biological_process def: "The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the mesenchymal cells of the renal system as it progresses from its formation to the mature state." [GOC:mtg_kidney_jan10, GOC:obol, GOC:yaf] synonym: "mesenchymal cell differentiation involved in urinary system development" RELATED [GOC:obol] synonym: "mesenchymal cell differentiation involved in urinary tract development" RELATED [GOC:obol] is_a: GO:0048762 ! mesenchymal cell differentiation intersection_of: GO:0048762 ! mesenchymal cell differentiation intersection_of: BFO:0000050 GO:0072001 ! part of renal system development relationship: BFO:0000050 GO:0072001 ! part of renal system development creation_date: 2011-08-09T04:05:14Z [Term] id: GO:2001013 name: epithelial cell proliferation involved in renal tubule morphogenesis namespace: biological_process def: "Any epithelial cell proliferation that is involved in renal tubule morphogenesis." [GOC:obol] is_a: GO:0050673 ! epithelial cell proliferation intersection_of: GO:0050673 ! epithelial cell proliferation intersection_of: BFO:0000050 GO:0061333 ! part of renal tubule morphogenesis relationship: BFO:0000050 GO:0061333 ! part of renal tubule morphogenesis creation_date: 2011-08-12T11:37:29Z [Term] id: GO:2001014 name: regulation of skeletal muscle cell differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of skeletal muscle cell differentiation." [GOC:obol] is_a: GO:0045595 ! regulation of cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0035914 ! regulates skeletal muscle cell differentiation relationship: RO:0002211 GO:0035914 ! regulates skeletal muscle cell differentiation creation_date: 2011-08-11T08:54:37Z [Term] id: GO:2001015 name: negative regulation of skeletal muscle cell differentiation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of skeletal muscle cell differentiation." [GOC:obol] is_a: GO:0045596 ! negative regulation of cell differentiation is_a: GO:2001014 ! regulation of skeletal muscle cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0035914 ! negatively regulates skeletal muscle cell differentiation relationship: RO:0002212 GO:0035914 ! negatively regulates skeletal muscle cell differentiation creation_date: 2011-08-11T08:54:41Z [Term] id: GO:2001016 name: positive regulation of skeletal muscle cell differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of skeletal muscle cell differentiation." [GOC:obol] is_a: GO:0045597 ! positive regulation of cell differentiation is_a: GO:2001014 ! regulation of skeletal muscle cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0035914 ! positively regulates skeletal muscle cell differentiation relationship: RO:0002213 GO:0035914 ! positively regulates skeletal muscle cell differentiation creation_date: 2011-08-11T08:54:44Z [Term] id: GO:2001017 name: regulation of retrograde axon cargo transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of retrograde axon cargo transport." [GOC:obol] synonym: "regulation of retrograde axonal transport" EXACT [GOC:obol] is_a: GO:0032386 ! regulation of intracellular transport is_a: GO:0060632 ! regulation of microtubule-based movement intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0008090 ! regulates retrograde axonal transport relationship: RO:0002211 GO:0008090 ! regulates retrograde axonal transport creation_date: 2011-08-11T09:44:42Z [Term] id: GO:2001018 name: negative regulation of retrograde axon cargo transport namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of retrograde axon cargo transport." [GOC:obol] synonym: "negative regulation of retrograde axonal transport" EXACT [GOC:obol] is_a: GO:0032387 ! negative regulation of intracellular transport is_a: GO:2001017 ! regulation of retrograde axon cargo transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0008090 ! negatively regulates retrograde axonal transport relationship: RO:0002212 GO:0008090 ! negatively regulates retrograde axonal transport creation_date: 2011-08-11T09:44:46Z [Term] id: GO:2001019 name: positive regulation of retrograde axon cargo transport namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of retrograde axon cargo transport." [GOC:obol] synonym: "positive regulation of retrograde axonal transport" EXACT [GOC:obol] is_a: GO:0032388 ! positive regulation of intracellular transport is_a: GO:2001017 ! regulation of retrograde axon cargo transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0008090 ! positively regulates retrograde axonal transport relationship: RO:0002213 GO:0008090 ! positively regulates retrograde axonal transport creation_date: 2011-08-11T09:44:49Z [Term] id: GO:2001026 name: regulation of endothelial cell chemotaxis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of endothelial cell chemotaxis." [GOC:BHF] is_a: GO:0010594 ! regulation of endothelial cell migration is_a: GO:0050920 ! regulation of chemotaxis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0035767 ! regulates endothelial cell chemotaxis relationship: RO:0002211 GO:0035767 ! regulates endothelial cell chemotaxis property_value: RO:0002161 NCBITaxon:451864 creation_date: 2011-08-22T01:07:26Z [Term] id: GO:2001027 name: negative regulation of endothelial cell chemotaxis namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of endothelial cell chemotaxis." [GOC:BHF] is_a: GO:0010596 ! negative regulation of endothelial cell migration is_a: GO:0050922 ! negative regulation of chemotaxis is_a: GO:2001026 ! regulation of endothelial cell chemotaxis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0035767 ! negatively regulates endothelial cell chemotaxis relationship: RO:0002212 GO:0035767 ! negatively regulates endothelial cell chemotaxis property_value: RO:0002161 NCBITaxon:451864 creation_date: 2011-08-22T01:07:31Z [Term] id: GO:2001028 name: positive regulation of endothelial cell chemotaxis namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of endothelial cell chemotaxis." [GOC:BHF] is_a: GO:0010595 ! positive regulation of endothelial cell migration is_a: GO:0050921 ! positive regulation of chemotaxis is_a: GO:2001026 ! regulation of endothelial cell chemotaxis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0035767 ! positively regulates endothelial cell chemotaxis relationship: RO:0002213 GO:0035767 ! positively regulates endothelial cell chemotaxis property_value: RO:0002161 NCBITaxon:451864 creation_date: 2011-08-22T01:07:34Z [Term] id: GO:2001035 name: regulation of tongue muscle cell differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of tongue muscle cell differentiation." [GOC:obol] is_a: GO:1902809 ! regulation of skeletal muscle fiber differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0035981 ! regulates tongue muscle cell differentiation relationship: RO:0002211 GO:0035981 ! regulates tongue muscle cell differentiation creation_date: 2011-08-24T11:10:16Z [Term] id: GO:2001036 name: negative regulation of tongue muscle cell differentiation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of tongue muscle cell differentiation." [GOC:obol] is_a: GO:1902810 ! negative regulation of skeletal muscle fiber differentiation is_a: GO:2001035 ! regulation of tongue muscle cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0035981 ! negatively regulates tongue muscle cell differentiation relationship: RO:0002212 GO:0035981 ! negatively regulates tongue muscle cell differentiation creation_date: 2011-08-24T11:10:20Z [Term] id: GO:2001037 name: positive regulation of tongue muscle cell differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of tongue muscle cell differentiation." [GOC:obol] is_a: GO:1902811 ! positive regulation of skeletal muscle fiber differentiation is_a: GO:2001035 ! regulation of tongue muscle cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0035981 ! positively regulates tongue muscle cell differentiation relationship: RO:0002213 GO:0035981 ! positively regulates tongue muscle cell differentiation creation_date: 2011-08-24T11:10:22Z [Term] id: GO:2001049 name: regulation of tendon cell differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of tendon cell differentiation." [GOC:obol] synonym: "regulation of muscle attachment cell differentiation" EXACT [GOC:obol] synonym: "regulation of tenocyte differentiation" RELATED [GOC:obol] is_a: GO:0045595 ! regulation of cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0035990 ! regulates tendon cell differentiation relationship: RO:0002211 GO:0035990 ! regulates tendon cell differentiation creation_date: 2011-09-01T09:20:32Z [Term] id: GO:2001050 name: negative regulation of tendon cell differentiation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of tendon cell differentiation." [GOC:obol] synonym: "negative regulation of muscle attachment cell differentiation" EXACT [GOC:obol] synonym: "negative regulation of tenocyte differentiation" RELATED [GOC:obol] is_a: GO:0045596 ! negative regulation of cell differentiation is_a: GO:2001049 ! regulation of tendon cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0035990 ! negatively regulates tendon cell differentiation relationship: RO:0002212 GO:0035990 ! negatively regulates tendon cell differentiation creation_date: 2011-09-01T09:20:38Z [Term] id: GO:2001051 name: positive regulation of tendon cell differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of tendon cell differentiation." [GOC:obol] synonym: "positive regulation of muscle attachment cell differentiation" EXACT [GOC:obol] synonym: "positive regulation of tenocyte differentiation" RELATED [GOC:obol] is_a: GO:0045597 ! positive regulation of cell differentiation is_a: GO:2001049 ! regulation of tendon cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0035990 ! positively regulates tendon cell differentiation relationship: RO:0002213 GO:0035990 ! positively regulates tendon cell differentiation creation_date: 2011-09-01T09:20:42Z [Term] id: GO:2001053 name: regulation of mesenchymal cell apoptotic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of mesenchymal cell apoptotic process." [GOC:mtg_apoptosis, GOC:obol] synonym: "regulation of mesenchymal cell apoptosis" NARROW [] is_a: GO:0042981 ! regulation of apoptotic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0097152 ! regulates mesenchymal cell apoptotic process relationship: RO:0002211 GO:0097152 ! regulates mesenchymal cell apoptotic process property_value: RO:0002161 NCBITaxon:4896 creation_date: 2011-09-08T02:49:59Z [Term] id: GO:2001054 name: negative regulation of mesenchymal cell apoptotic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of mesenchymal cell apoptotic process." [GOC:mtg_apoptosis, GOC:obol] synonym: "negative regulation of mesenchymal cell apoptosis" NARROW [] is_a: GO:0043066 ! negative regulation of apoptotic process is_a: GO:2001053 ! regulation of mesenchymal cell apoptotic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0097152 ! negatively regulates mesenchymal cell apoptotic process relationship: RO:0002212 GO:0097152 ! negatively regulates mesenchymal cell apoptotic process property_value: RO:0002161 NCBITaxon:4896 creation_date: 2011-09-08T02:50:05Z [Term] id: GO:2001055 name: positive regulation of mesenchymal cell apoptotic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of mesenchymal cell apoptotic process." [GOC:mtg_apoptosis, GOC:obol] synonym: "positive regulation of mesenchymal cell apoptosis" NARROW [] is_a: GO:0043065 ! positive regulation of apoptotic process is_a: GO:2001053 ! regulation of mesenchymal cell apoptotic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0097152 ! positively regulates mesenchymal cell apoptotic process relationship: RO:0002213 GO:0097152 ! positively regulates mesenchymal cell apoptotic process property_value: RO:0002161 NCBITaxon:4896 creation_date: 2011-09-08T02:50:09Z [Term] id: GO:2001057 name: reactive nitrogen species metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a reactive nitrogen species." [GOC:obol] synonym: "reactive nitrogen species metabolism" EXACT [GOC:obol] synonym: "RNS metabolic process" EXACT [GOC:obol] synonym: "RNS metabolism" EXACT [GOC:obol] is_a: BFO:0000003 is_a: GO:0008152 ! metabolic process intersection_of: GO:0008152 ! metabolic process intersection_of: RO:0004007 CHEBI:62764 ! has primary input or output relationship: RO:0004007 CHEBI:62764 ! has primary input or output creation_date: 2011-09-09T01:29:13Z [Term] id: GO:2001069 name: glycogen binding namespace: molecular_function def: "Binding to glycogen." [GOC:mengo_curators] synonym: "animal starch binding" RELATED [GOC:obol] synonym: "liver starch binding" RELATED [GOC:obol] is_a: GO:0030247 ! polysaccharide binding intersection_of: GO:0005488 ! binding intersection_of: RO:0004009 CHEBI:28087 ! has primary input relationship: RO:0004009 CHEBI:28087 ! has primary input creation_date: 2011-09-14T12:01:06Z [Term] id: GO:2001070 name: starch binding namespace: molecular_function def: "Binding to starch." [GOC:mengo_curators] synonym: "amidon binding" RELATED [GOC:obol] synonym: "amylum binding" RELATED [GOC:obol] is_a: GO:0030247 ! polysaccharide binding intersection_of: GO:0005488 ! binding intersection_of: RO:0004009 CHEBI:28017 ! has primary input relationship: RO:0004009 CHEBI:28017 ! has primary input creation_date: 2011-09-14T12:02:50Z [Term] id: GO:2001141 name: regulation of RNA biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of RNA biosynthetic process." [GOC:dph] synonym: "regulation of RNA anabolism" EXACT [GOC:obol] synonym: "regulation of RNA biosynthesis" EXACT [GOC:obol] synonym: "regulation of RNA formation" EXACT [GOC:obol] synonym: "regulation of RNA synthesis" EXACT [GOC:obol] is_a: GO:0010556 ! regulation of macromolecule biosynthetic process is_a: GO:0051252 ! regulation of RNA metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0032774 ! regulates RNA biosynthetic process relationship: RO:0002211 GO:0032774 ! regulates RNA biosynthetic process creation_date: 2011-10-17T11:36:25Z [Term] id: GO:2001151 name: regulation of renal water transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of renal water transport." [GOC:obol] is_a: GO:0050878 ! regulation of body fluid levels is_a: GO:0051049 ! regulation of transport is_a: GO:0098801 ! regulation of renal system process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0003097 ! regulates renal water transport relationship: RO:0002211 GO:0003097 ! regulates renal water transport property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 creation_date: 2011-10-24T11:37:51Z [Term] id: GO:2001152 name: negative regulation of renal water transport namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of renal water transport." [GOC:obol] is_a: GO:0051051 ! negative regulation of transport is_a: GO:0051241 ! negative regulation of multicellular organismal process is_a: GO:2001151 ! regulation of renal water transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0003097 ! negatively regulates renal water transport relationship: RO:0002212 GO:0003097 ! negatively regulates renal water transport property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 creation_date: 2011-10-24T11:37:57Z [Term] id: GO:2001153 name: positive regulation of renal water transport namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of renal water transport." [GOC:obol] is_a: GO:0051050 ! positive regulation of transport is_a: GO:0051240 ! positive regulation of multicellular organismal process is_a: GO:2001151 ! regulation of renal water transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0003097 ! positively regulates renal water transport relationship: RO:0002213 GO:0003097 ! positively regulates renal water transport property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 creation_date: 2011-10-24T11:38:01Z [Term] id: GO:2001169 name: regulation of ATP biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of ATP biosynthetic process." [GOC:obol] synonym: "regulation of ATP anabolism" EXACT [GOC:obol] synonym: "regulation of ATP biosynthesis" EXACT [GOC:obol] synonym: "regulation of ATP formation" EXACT [GOC:obol] synonym: "regulation of ATP regeneration" RELATED [GOC:obol] synonym: "regulation of ATP synthesis" EXACT [GOC:obol] is_a: GO:1900371 ! regulation of purine nucleotide biosynthetic process is_a: GO:1903578 ! regulation of ATP metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0006754 ! regulates ATP biosynthetic process relationship: RO:0002211 GO:0006754 ! regulates ATP biosynthetic process creation_date: 2011-10-26T03:18:03Z [Term] id: GO:2001170 name: negative regulation of ATP biosynthetic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of ATP biosynthetic process." [GOC:obol] synonym: "negative regulation of ATP anabolism" EXACT [GOC:obol] synonym: "negative regulation of ATP biosynthesis" EXACT [GOC:obol] synonym: "negative regulation of ATP formation" EXACT [GOC:obol] synonym: "negative regulation of ATP regeneration" RELATED [GOC:obol] synonym: "negative regulation of ATP synthesis" EXACT [GOC:obol] is_a: GO:1900372 ! negative regulation of purine nucleotide biosynthetic process is_a: GO:1903579 ! negative regulation of ATP metabolic process is_a: GO:2001169 ! regulation of ATP biosynthetic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0006754 ! negatively regulates ATP biosynthetic process relationship: RO:0002212 GO:0006754 ! negatively regulates ATP biosynthetic process creation_date: 2011-10-26T03:18:13Z [Term] id: GO:2001171 name: positive regulation of ATP biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of ATP biosynthetic process." [GOC:obol] synonym: "positive regulation of ATP anabolism" EXACT [GOC:obol] synonym: "positive regulation of ATP biosynthesis" EXACT [GOC:obol] synonym: "positive regulation of ATP formation" EXACT [GOC:obol] synonym: "positive regulation of ATP regeneration" RELATED [GOC:obol] synonym: "positive regulation of ATP synthesis" EXACT [GOC:obol] is_a: GO:1900373 ! positive regulation of purine nucleotide biosynthetic process is_a: GO:1903580 ! positive regulation of ATP metabolic process is_a: GO:2001169 ! regulation of ATP biosynthetic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0006754 ! positively regulates ATP biosynthetic process relationship: RO:0002213 GO:0006754 ! positively regulates ATP biosynthetic process creation_date: 2011-10-26T03:18:26Z [Term] id: GO:2001185 name: regulation of CD8-positive, alpha-beta T cell activation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of CD8-positive, alpha-beta T cell activation." [GOC:obol] is_a: GO:0046634 ! regulation of alpha-beta T cell activation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0036037 ! regulates CD8-positive, alpha-beta T cell activation relationship: RO:0002211 GO:0036037 ! regulates CD8-positive, alpha-beta T cell activation creation_date: 2011-11-03T01:16:51Z [Term] id: GO:2001186 name: negative regulation of CD8-positive, alpha-beta T cell activation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of CD8-positive, alpha-beta T cell activation." [GOC:obol] is_a: GO:0046636 ! negative regulation of alpha-beta T cell activation is_a: GO:2001185 ! regulation of CD8-positive, alpha-beta T cell activation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0036037 ! negatively regulates CD8-positive, alpha-beta T cell activation relationship: RO:0002212 GO:0036037 ! negatively regulates CD8-positive, alpha-beta T cell activation creation_date: 2011-11-03T01:16:57Z [Term] id: GO:2001187 name: positive regulation of CD8-positive, alpha-beta T cell activation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of CD8-positive, alpha-beta T cell activation." [GOC:obol] is_a: GO:0046635 ! positive regulation of alpha-beta T cell activation is_a: GO:2001185 ! regulation of CD8-positive, alpha-beta T cell activation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0036037 ! positively regulates CD8-positive, alpha-beta T cell activation relationship: RO:0002213 GO:0036037 ! positively regulates CD8-positive, alpha-beta T cell activation creation_date: 2011-11-03T01:17:02Z [Term] id: GO:2001191 name: regulation of gamma-delta T cell activation involved in immune response namespace: biological_process def: "Any process that modulates the frequency, rate or extent of gamma-delta T cell activation involved in immune response." [GOC:obol] synonym: "regulation of gamma-delta T cell activation during immune response" RELATED [GOC:obol] synonym: "regulation of gamma-delta T lymphocyte activation during immune response" RELATED [GOC:obol] synonym: "regulation of gamma-delta T-cell activation during immune response" RELATED [GOC:obol] synonym: "regulation of gamma-delta T-lymphocyte activation during immune response" RELATED [GOC:obol] is_a: GO:0002697 ! regulation of immune effector process is_a: GO:0046643 ! regulation of gamma-delta T cell activation is_a: GO:0050776 ! regulation of immune response intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0002290 ! regulates gamma-delta T cell activation involved in immune response relationship: RO:0002211 GO:0002290 ! regulates gamma-delta T cell activation involved in immune response creation_date: 2011-11-03T04:28:38Z [Term] id: GO:2001192 name: negative regulation of gamma-delta T cell activation involved in immune response namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of gamma-delta T cell activation involved in immune response." [GOC:obol] synonym: "negative regulation of gamma-delta T cell activation during immune response" RELATED [GOC:obol] synonym: "negative regulation of gamma-delta T lymphocyte activation during immune response" RELATED [GOC:obol] synonym: "negative regulation of gamma-delta T-cell activation during immune response" RELATED [GOC:obol] synonym: "negative regulation of gamma-delta T-lymphocyte activation during immune response" RELATED [GOC:obol] is_a: GO:0002698 ! negative regulation of immune effector process is_a: GO:0046644 ! negative regulation of gamma-delta T cell activation is_a: GO:0050777 ! negative regulation of immune response is_a: GO:2001191 ! regulation of gamma-delta T cell activation involved in immune response intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0002290 ! negatively regulates gamma-delta T cell activation involved in immune response relationship: RO:0002212 GO:0002290 ! negatively regulates gamma-delta T cell activation involved in immune response creation_date: 2011-11-03T04:28:44Z [Term] id: GO:2001193 name: positive regulation of gamma-delta T cell activation involved in immune response namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of gamma-delta T cell activation involved in immune response." [GOC:obol] synonym: "positive regulation of gamma-delta T cell activation during immune response" RELATED [GOC:obol] synonym: "positive regulation of gamma-delta T lymphocyte activation during immune response" RELATED [GOC:obol] synonym: "positive regulation of gamma-delta T-cell activation during immune response" RELATED [GOC:obol] synonym: "positive regulation of gamma-delta T-lymphocyte activation during immune response" RELATED [GOC:obol] is_a: GO:0002699 ! positive regulation of immune effector process is_a: GO:0046645 ! positive regulation of gamma-delta T cell activation is_a: GO:0050778 ! positive regulation of immune response is_a: GO:2001191 ! regulation of gamma-delta T cell activation involved in immune response intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0002290 ! positively regulates gamma-delta T cell activation involved in immune response relationship: RO:0002213 GO:0002290 ! positively regulates gamma-delta T cell activation involved in immune response creation_date: 2011-11-03T04:28:48Z [Term] id: GO:2001198 name: regulation of dendritic cell differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of dendritic cell differentiation." [GOC:obol] is_a: GO:1902105 ! regulation of leukocyte differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0097028 ! regulates dendritic cell differentiation relationship: RO:0002211 GO:0097028 ! regulates dendritic cell differentiation creation_date: 2011-11-04T02:01:27Z [Term] id: GO:2001199 name: negative regulation of dendritic cell differentiation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of dendritic cell differentiation." [GOC:obol] is_a: GO:1902106 ! negative regulation of leukocyte differentiation is_a: GO:2001198 ! regulation of dendritic cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0097028 ! negatively regulates dendritic cell differentiation relationship: RO:0002212 GO:0097028 ! negatively regulates dendritic cell differentiation creation_date: 2011-11-04T02:01:33Z [Term] id: GO:2001200 name: positive regulation of dendritic cell differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of dendritic cell differentiation." [GOC:obol] is_a: GO:1902107 ! positive regulation of leukocyte differentiation is_a: GO:2001198 ! regulation of dendritic cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0097028 ! positively regulates dendritic cell differentiation relationship: RO:0002213 GO:0097028 ! positively regulates dendritic cell differentiation creation_date: 2011-11-04T02:01:36Z [Term] id: GO:2001204 name: regulation of osteoclast development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of osteoclast development." [GOC:obol] synonym: "regulation of osteoclast cell development" EXACT [GOC:obol] is_a: GO:1903706 ! regulation of hemopoiesis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0036035 ! regulates osteoclast development relationship: RO:0002211 GO:0036035 ! regulates osteoclast development creation_date: 2011-11-10T10:58:59Z [Term] id: GO:2001205 name: negative regulation of osteoclast development namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of osteoclast development." [GOC:obol] synonym: "negative regulation of osteoclast cell development" EXACT [GOC:obol] is_a: GO:0045671 ! negative regulation of osteoclast differentiation is_a: GO:2001204 ! regulation of osteoclast development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0036035 ! negatively regulates osteoclast development relationship: RO:0002212 GO:0036035 ! negatively regulates osteoclast development creation_date: 2011-11-10T10:59:06Z [Term] id: GO:2001206 name: positive regulation of osteoclast development namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of osteoclast development." [GOC:obol] synonym: "positive regulation of osteoclast cell development" EXACT [GOC:obol] is_a: GO:0045672 ! positive regulation of osteoclast differentiation is_a: GO:2001204 ! regulation of osteoclast development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0036035 ! positively regulates osteoclast development relationship: RO:0002213 GO:0036035 ! positively regulates osteoclast development creation_date: 2011-11-10T10:59:12Z [Term] id: GO:2001212 name: regulation of vasculogenesis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of vasculogenesis." [GOC:obol] synonym: "regulation of vascular morphogenesis" EXACT [GOC:obol] is_a: GO:0045595 ! regulation of cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0001570 ! regulates vasculogenesis relationship: RO:0002211 GO:0001570 ! regulates vasculogenesis creation_date: 2011-11-15T01:22:31Z [Term] id: GO:2001213 name: negative regulation of vasculogenesis namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of vasculogenesis." [GOC:obol] synonym: "negative regulation of vascular morphogenesis" EXACT [GOC:obol] is_a: GO:0045596 ! negative regulation of cell differentiation is_a: GO:2001212 ! regulation of vasculogenesis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0001570 ! negatively regulates vasculogenesis relationship: RO:0002212 GO:0001570 ! negatively regulates vasculogenesis creation_date: 2011-11-15T01:22:36Z [Term] id: GO:2001214 name: positive regulation of vasculogenesis namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of vasculogenesis." [GOC:obol] synonym: "positive regulation of vascular morphogenesis" EXACT [GOC:obol] is_a: GO:0045597 ! positive regulation of cell differentiation is_a: GO:2001212 ! regulation of vasculogenesis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0001570 ! positively regulates vasculogenesis relationship: RO:0002213 GO:0001570 ! positively regulates vasculogenesis creation_date: 2011-11-15T01:22:39Z [Term] id: GO:2001222 name: regulation of neuron migration namespace: biological_process def: "Any process that modulates the frequency, rate or extent of neuron migration." [GOC:obol] synonym: "regulation of neuron chemotaxis" EXACT [GOC:obol] synonym: "regulation of neuron guidance" RELATED [GOC:obol] synonym: "regulation of neuronal migration" EXACT [GOC:obol] is_a: GO:0030334 ! regulation of cell migration intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0001764 ! regulates neuron migration relationship: RO:0002211 GO:0001764 ! regulates neuron migration creation_date: 2011-11-17T10:01:38Z [Term] id: GO:2001223 name: negative regulation of neuron migration namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of neuron migration." [GOC:obol] synonym: "negative regulation of neuron chemotaxis" EXACT [GOC:obol] synonym: "negative regulation of neuron guidance" RELATED [GOC:obol] synonym: "negative regulation of neuronal migration" EXACT [GOC:obol] is_a: GO:0030336 ! negative regulation of cell migration is_a: GO:2001222 ! regulation of neuron migration intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0001764 ! negatively regulates neuron migration relationship: RO:0002212 GO:0001764 ! negatively regulates neuron migration creation_date: 2011-11-17T10:01:45Z [Term] id: GO:2001224 name: positive regulation of neuron migration namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of neuron migration." [GOC:obol] synonym: "positive regulation of neuron chemotaxis" EXACT [GOC:obol] synonym: "positive regulation of neuron guidance" RELATED [GOC:obol] synonym: "positive regulation of neuronal migration" EXACT [GOC:obol] is_a: GO:0030335 ! positive regulation of cell migration is_a: GO:2001222 ! regulation of neuron migration intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0001764 ! positively regulates neuron migration relationship: RO:0002213 GO:0001764 ! positively regulates neuron migration creation_date: 2011-11-17T10:01:49Z [Term] id: GO:2001233 name: regulation of apoptotic signaling pathway namespace: biological_process def: "Any process that modulates the frequency, rate or extent of apoptotic signaling pathway." [GOC:mtg_apoptosis] synonym: "regulation of apoptotic signalling pathway" EXACT [GOC:mah] is_a: GO:0009966 ! regulation of signal transduction is_a: GO:0042981 ! regulation of apoptotic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0097190 ! regulates apoptotic signaling pathway relationship: RO:0002211 GO:0097190 ! regulates apoptotic signaling pathway property_value: RO:0002161 NCBITaxon:4896 creation_date: 2011-11-24T01:20:49Z [Term] id: GO:2001234 name: negative regulation of apoptotic signaling pathway namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of apoptotic signaling pathway." [GOC:mtg_apoptosis] synonym: "negative regulation of apoptotic signalling pathway" EXACT [GOC:mah] is_a: GO:0009968 ! negative regulation of signal transduction is_a: GO:0043066 ! negative regulation of apoptotic process is_a: GO:2001233 ! regulation of apoptotic signaling pathway intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0097190 ! negatively regulates apoptotic signaling pathway relationship: RO:0002212 GO:0097190 ! negatively regulates apoptotic signaling pathway property_value: RO:0002161 NCBITaxon:4896 creation_date: 2011-11-24T01:20:54Z [Term] id: GO:2001235 name: positive regulation of apoptotic signaling pathway namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of apoptotic signaling pathway." [GOC:mtg_apoptosis] synonym: "positive regulation of apoptotic signalling pathway" EXACT [GOC:mah] is_a: GO:0009967 ! positive regulation of signal transduction is_a: GO:0043065 ! positive regulation of apoptotic process is_a: GO:2001233 ! regulation of apoptotic signaling pathway intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0097190 ! positively regulates apoptotic signaling pathway relationship: RO:0002213 GO:0097190 ! positively regulates apoptotic signaling pathway property_value: RO:0002161 NCBITaxon:4896 creation_date: 2011-11-24T01:20:58Z [Term] id: GO:2001236 name: regulation of extrinsic apoptotic signaling pathway namespace: biological_process def: "Any process that modulates the frequency, rate or extent of extrinsic apoptotic signaling pathway." [GOC:mtg_apoptosis] synonym: "regulation of extrinsic apoptosis" NARROW [] synonym: "regulation of extrinsic apoptotic signalling pathway" EXACT [GOC:mah] is_a: GO:2001233 ! regulation of apoptotic signaling pathway intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0097191 ! regulates extrinsic apoptotic signaling pathway relationship: RO:0002211 GO:0097191 ! regulates extrinsic apoptotic signaling pathway property_value: RO:0002161 NCBITaxon:4896 creation_date: 2011-11-24T01:30:05Z [Term] id: GO:2001237 name: negative regulation of extrinsic apoptotic signaling pathway namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of extrinsic apoptotic signaling pathway." [GOC:mtg_apoptosis] synonym: "negative regulation of extrinsic apoptosis" NARROW [] synonym: "negative regulation of extrinsic apoptotic signalling pathway" EXACT [GOC:mah] is_a: GO:2001234 ! negative regulation of apoptotic signaling pathway is_a: GO:2001236 ! regulation of extrinsic apoptotic signaling pathway intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0097191 ! negatively regulates extrinsic apoptotic signaling pathway relationship: RO:0002212 GO:0097191 ! negatively regulates extrinsic apoptotic signaling pathway property_value: RO:0002161 NCBITaxon:4896 creation_date: 2011-11-24T01:30:11Z [Term] id: GO:2001238 name: positive regulation of extrinsic apoptotic signaling pathway namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of extrinsic apoptotic signaling pathway." [GOC:mtg_apoptosis] synonym: "positive regulation of extrinsic apoptosis" NARROW [] synonym: "positive regulation of extrinsic apoptotic signalling pathway" EXACT [GOC:mah] is_a: GO:2001235 ! positive regulation of apoptotic signaling pathway is_a: GO:2001236 ! regulation of extrinsic apoptotic signaling pathway intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0097191 ! positively regulates extrinsic apoptotic signaling pathway relationship: RO:0002213 GO:0097191 ! positively regulates extrinsic apoptotic signaling pathway property_value: RO:0002161 NCBITaxon:4896 creation_date: 2011-11-24T01:30:16Z [Term] id: GO:2001251 name: negative regulation of chromosome organization namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of chromosome organization." [GOC:obol] synonym: "negative regulation of chromosome organisation" EXACT [GOC:obol] synonym: "negative regulation of chromosome organization and biogenesis" RELATED [GOC:obol] synonym: "negative regulation of maintenance of genome integrity" RELATED [GOC:obol] synonym: "negative regulation of nuclear genome maintenance" RELATED [GOC:obol] is_a: GO:0010639 ! negative regulation of organelle organization is_a: GO:0033044 ! regulation of chromosome organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0051276 ! negatively regulates chromosome organization relationship: RO:0002212 GO:0051276 ! negatively regulates chromosome organization creation_date: 2011-12-02T02:01:20Z [Term] id: GO:2001252 name: positive regulation of chromosome organization namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of chromosome organization." [GOC:obol] synonym: "positive regulation of chromosome organisation" EXACT [GOC:obol] synonym: "positive regulation of chromosome organization and biogenesis" RELATED [GOC:obol] synonym: "positive regulation of maintenance of genome integrity" RELATED [GOC:obol] synonym: "positive regulation of nuclear genome maintenance" RELATED [GOC:obol] is_a: GO:0010638 ! positive regulation of organelle organization is_a: GO:0033044 ! regulation of chromosome organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0051276 ! positively regulates chromosome organization relationship: RO:0002213 GO:0051276 ! positively regulates chromosome organization creation_date: 2011-12-02T02:01:26Z [Term] id: GO:2001259 name: positive regulation of cation channel activity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cation channel activity." [GOC:BHF] subset: gocheck_obsoletion_candidate synonym: "positive regulation of cation diffusion facilitator activity" EXACT [GOC:obol] synonym: "positive regulation of nonselective cation channel activity" EXACT [GOC:obol] is_a: GO:0032414 ! positive regulation of ion transmembrane transporter activity is_a: GO:1904064 ! positive regulation of cation transmembrane transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0005261 ! positively regulates monoatomic cation channel activity relationship: RO:0002213 GO:0005261 ! positively regulates monoatomic cation channel activity creation_date: 2011-12-07T07:14:57Z [Term] id: GO:7770012 name: negative regulation of starch biosynthetic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of starch." [PMID:26554020] is_a: GO:0010558 ! negative regulation of macromolecule biosynthetic process is_a: GO:0010581 ! regulation of starch biosynthetic process is_a: GO:0045912 ! negative regulation of carbohydrate metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0019252 ! negatively regulates starch biosynthetic process relationship: RO:0002212 GO:0019252 ! negatively regulates starch biosynthetic process property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/30662" xsd:anyURI creation_date: 2025-08-01T12:00:00Z [Term] id: IAO:0000027 name: data item is_a: IAO:0000030 ! information content entity [Term] id: IAO:0000030 name: information content entity [Term] id: IAO:0000078 name: curation status specification def: "The curation status of the term. The allowed values come from an enumerated list of predefined terms. See the specification of these instances for more detailed definitions of each enumerated value." [] is_a: IAO:0000102 ! data about an ontology part property_value: IAO:0000116 "Better to represent curation as a process with parts and then relate labels to that process (in IAO meeting)" xsd:string [Term] id: IAO:0000102 name: data about an ontology part def: "Data about an ontology part is a data item about a part of an ontology, for example a term" [] is_a: IAO:0000027 ! data item [Term] id: IAO:0000225 name: obsolescence reason specification def: "The reason for which a term has been deprecated. The allowed values come from an enumerated list of predefined terms. See the specification of these instances for more detailed definitions of each enumerated value." [] is_a: IAO:0000102 ! data about an ontology part property_value: IAO:0000116 "The creation of this class has been inspired in part by Werner Ceusters' paper, Applying evolutionary terminology auditing to the Gene Ontology." xsd:string [Term] id: IAO:0000409 name: denotator type def: "A denotator type indicates how a term should be interpreted from an ontological perspective." [] is_a: IAO:0000102 ! data about an ontology part [Term] id: MBA:1000 name: extrapyramidal fiber systems synonym: "eps" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=1#structure=1000 xref: http://atlas.brain-map.org/atlas?atlas=2#structure=1000 xref: http://atlas.brain-map.org/atlas?atlas=602630314#structure=1000 is_a: MBA:8 ! Basic cell groups and regions is_a: UBERON:0035803 ! extrapyramidal tract system intersection_of: UBERON:0035803 ! extrapyramidal tract system intersection_of: BFO:0000050 NCBITaxon:10090 ! part of Mus musculus relationship: BFO:0000050 MBA:1009 ! part of fiber tracts property_value: IAO:0000028 "eps" xsd:string property_value: skos:prefLabel "extrapyramidal fiber systems ( mouse )" xsd:string [Term] id: MBA:1008 name: Geniculate group, dorsal thalamus synonym: "GENd" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=1#structure=1008 xref: http://atlas.brain-map.org/atlas?atlas=2#structure=1008 xref: http://atlas.brain-map.org/atlas?atlas=602630314#structure=1008 is_a: MBA:ENTITY is_a: UBERON:0002704 ! metathalamus is_a: UBERON:0006331 ! brainstem nucleus intersection_of: UBERON:0002704 ! metathalamus intersection_of: BFO:0000050 NCBITaxon:10090 ! part of Mus musculus relationship: BFO:0000050 MBA:864 ! part of Thalamus, sensory-motor cortex related property_value: IAO:0000028 "GENd" xsd:string property_value: skos:prefLabel "Geniculate group, dorsal thalamus ( mouse )" xsd:string [Term] id: MBA:1009 name: fiber tracts synonym: "fiber tracts" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=1#structure=1009 xref: http://atlas.brain-map.org/atlas?atlas=2#structure=1009 xref: http://atlas.brain-map.org/atlas?atlas=602630314#structure=1009 is_a: MBA:ENTITY is_a: UBERON:0000122 ! neuron projection bundle is_a: UBERON:0011215 ! central nervous system cell part cluster intersection_of: UBERON:0000122 ! neuron projection bundle intersection_of: BFO:0000050 NCBITaxon:10090 ! part of Mus musculus relationship: BFO:0000050 MBA:997 ! part of brain property_value: IAO:0000028 "fiber tracts" xsd:string property_value: skos:prefLabel "fiber tracts ( mouse )" xsd:string [Term] id: MBA:101 name: Ventral cochlear nucleus synonym: "VCO" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=1#structure=101 xref: http://atlas.brain-map.org/atlas?atlas=2#structure=101 xref: http://atlas.brain-map.org/atlas?atlas=602630314#structure=101 is_a: MBA:ENTITY is_a: UBERON:0002828 ! ventral cochlear nucleus intersection_of: UBERON:0002828 ! ventral cochlear nucleus intersection_of: BFO:0000050 NCBITaxon:10090 ! part of Mus musculus relationship: BFO:0000050 MBA:607 ! part of Cochlear nuclei property_value: IAO:0000028 "VCO" xsd:string property_value: skos:prefLabel "Ventral cochlear nucleus ( mouse )" xsd:string [Term] id: MBA:1016 name: olfactory nerve layer of main olfactory bulb synonym: "onl" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=1#structure=1016 xref: http://atlas.brain-map.org/atlas?atlas=2#structure=1016 xref: http://atlas.brain-map.org/atlas?atlas=602630314#structure=1016 is_a: MBA:ENTITY is_a: UBERON:0005978 ! olfactory bulb outer nerve layer intersection_of: UBERON:0005978 ! olfactory bulb outer nerve layer intersection_of: BFO:0000050 NCBITaxon:10090 ! part of Mus musculus relationship: BFO:0000050 MBA:840 ! part of olfactory nerve property_value: IAO:0000028 "onl" xsd:string property_value: skos:prefLabel "olfactory nerve layer of main olfactory bulb ( mouse )" xsd:string [Term] id: MBA:1020 name: Posterior complex of the thalamus synonym: "PO" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=1#structure=1020 xref: http://atlas.brain-map.org/atlas?atlas=2#structure=1020 xref: http://atlas.brain-map.org/atlas?atlas=602630314#structure=1020 is_a: MBA:ENTITY is_a: UBERON:0002709 ! posterior nuclear complex of thalamus intersection_of: UBERON:0002709 ! posterior nuclear complex of thalamus intersection_of: BFO:0000050 NCBITaxon:10090 ! part of Mus musculus relationship: BFO:0000050 MBA:138 ! part of Lateral group of the dorsal thalamus property_value: IAO:0000028 "PO" xsd:string property_value: skos:prefLabel "Posterior complex of the thalamus ( mouse )" xsd:string [Term] id: MBA:1022 name: Globus pallidus, external segment synonym: "GPe" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=1#structure=1022 xref: http://atlas.brain-map.org/atlas?atlas=2#structure=1022 xref: http://atlas.brain-map.org/atlas?atlas=602630314#structure=1022 is_a: MBA:ENTITY is_a: UBERON:0002476 ! lateral globus pallidus intersection_of: UBERON:0002476 ! lateral globus pallidus intersection_of: BFO:0000050 NCBITaxon:10090 ! part of Mus musculus relationship: BFO:0000050 MBA:818 ! part of Pallidum, dorsal region property_value: IAO:0000028 "GPe" xsd:string property_value: skos:prefLabel "Globus pallidus, external segment ( mouse )" xsd:string [Term] id: MBA:1024 name: grooves synonym: "grv" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=1#structure=1024 xref: http://atlas.brain-map.org/atlas?atlas=2#structure=1024 xref: http://atlas.brain-map.org/atlas?atlas=602630314#structure=1024 is_a: MBA:ENTITY is_a: UBERON:0013118 ! sulcus of brain intersection_of: UBERON:0013118 ! sulcus of brain intersection_of: BFO:0000050 NCBITaxon:10090 ! part of Mus musculus relationship: BFO:0000050 MBA:997 ! part of brain property_value: IAO:0000028 "grv" xsd:string property_value: skos:prefLabel "grooves ( mouse )" xsd:string [Term] id: MBA:1031 name: Globus pallidus, internal segment synonym: "GPi" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=1#structure=1031 xref: http://atlas.brain-map.org/atlas?atlas=2#structure=1031 xref: http://atlas.brain-map.org/atlas?atlas=602630314#structure=1031 is_a: MBA:ENTITY is_a: UBERON:0002477 ! medial globus pallidus intersection_of: UBERON:0002477 ! medial globus pallidus intersection_of: BFO:0000050 NCBITaxon:10090 ! part of Mus musculus relationship: BFO:0000050 MBA:818 ! part of Pallidum, dorsal region property_value: IAO:0000028 "GPi" xsd:string property_value: skos:prefLabel "Globus pallidus, internal segment ( mouse )" xsd:string [Term] id: MBA:1041 name: Paraflocculus synonym: "PFL" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=1#structure=1041 xref: http://atlas.brain-map.org/atlas?atlas=2#structure=1041 xref: http://atlas.brain-map.org/atlas?atlas=602630314#structure=1041 is_a: MBA:8 ! Basic cell groups and regions is_a: UBERON:0005351 ! paraflocculus intersection_of: UBERON:0005351 ! paraflocculus intersection_of: BFO:0000050 NCBITaxon:10090 ! part of Mus musculus relationship: BFO:0000050 MBA:1073 ! part of Hemispheric regions property_value: IAO:0000028 "PFL" xsd:string property_value: skos:prefLabel "Paraflocculus ( mouse )" xsd:string [Term] id: MBA:1049 name: Flocculus synonym: "FL" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=1#structure=1049 xref: http://atlas.brain-map.org/atlas?atlas=2#structure=1049 xref: http://atlas.brain-map.org/atlas?atlas=602630314#structure=1049 is_a: MBA:8 ! Basic cell groups and regions is_a: UBERON:0001063 ! flocculus intersection_of: UBERON:0001063 ! flocculus intersection_of: BFO:0000050 NCBITaxon:10090 ! part of Mus musculus relationship: BFO:0000050 MBA:1073 ! part of Hemispheric regions property_value: IAO:0000028 "FL" xsd:string property_value: skos:prefLabel "Flocculus ( mouse )" xsd:string [Term] id: MBA:1052 name: Pedunculopontine nucleus synonym: "PPN" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=1#structure=1052 xref: http://atlas.brain-map.org/atlas?atlas=2#structure=1052 xref: http://atlas.brain-map.org/atlas?atlas=602630314#structure=1052 is_a: MBA:128 ! Midbrain reticular nucleus is_a: UBERON:0002142 ! pedunculopontine tegmental nucleus intersection_of: UBERON:0002142 ! pedunculopontine tegmental nucleus intersection_of: BFO:0000050 NCBITaxon:10090 ! part of Mus musculus relationship: BFO:0000050 MBA:348 ! part of Midbrain, behavioral state related property_value: IAO:0000028 "PPN" xsd:string property_value: skos:prefLabel "Pedunculopontine nucleus ( mouse )" xsd:string [Term] id: MBA:1065 name: Hindbrain synonym: "HB" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=1#structure=1065 xref: http://atlas.brain-map.org/atlas?atlas=2#structure=1065 xref: http://atlas.brain-map.org/atlas?atlas=602630314#structure=1065 is_a: MBA:8 ! Basic cell groups and regions is_a: UBERON:0002028 ! hindbrain intersection_of: UBERON:0002028 ! hindbrain intersection_of: BFO:0000050 NCBITaxon:10090 ! part of Mus musculus relationship: BFO:0000050 MBA:343 ! part of Brain stem property_value: IAO:0000028 "HB" xsd:string property_value: skos:prefLabel "Hindbrain ( mouse )" xsd:string [Term] id: MBA:10671 name: Median eminence synonym: "ME" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=1#structure=10671 xref: http://atlas.brain-map.org/atlas?atlas=2#structure=10671 xref: http://atlas.brain-map.org/atlas?atlas=602630314#structure=10671 is_a: MBA:8 ! Basic cell groups and regions is_a: UBERON:0002197 ! median eminence of neurohypophysis intersection_of: UBERON:0002197 ! median eminence of neurohypophysis intersection_of: BFO:0000050 NCBITaxon:10090 ! part of Mus musculus relationship: BFO:0000050 MBA:1097 ! part of Hypothalamus property_value: IAO:0000028 "ME" xsd:string property_value: skos:prefLabel "Median eminence ( mouse )" xsd:string [Term] id: MBA:10687 name: Paraflocculus, granular layer synonym: "PFLgr" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=1#structure=10687 xref: http://atlas.brain-map.org/atlas?atlas=2#structure=10687 xref: http://atlas.brain-map.org/atlas?atlas=602630314#structure=10687 is_a: MBA:1143 ! Cerebellar cortex, granular layer intersection_of: BFO:0000050 NCBITaxon:10090 {all_some="true"} ! part of Mus musculus intersection_of: BFO:0000050 UBERON:0005351 ! part of paraflocculus relationship: BFO:0000050 MBA:1041 ! part of Paraflocculus property_value: IAO:0000028 "PFLgr" xsd:string property_value: skos:prefLabel "Paraflocculus, granular layer ( mouse )" xsd:string [Term] id: MBA:10688 name: Paraflocculus, Purkinje layer synonym: "PFLpu" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=1#structure=10688 xref: http://atlas.brain-map.org/atlas?atlas=2#structure=10688 xref: http://atlas.brain-map.org/atlas?atlas=602630314#structure=10688 is_a: MBA:1145 ! Cerebellar cortex, Purkinje layer intersection_of: BFO:0000050 NCBITaxon:10090 {all_some="true"} ! part of Mus musculus intersection_of: BFO:0000050 UBERON:0005351 ! part of paraflocculus relationship: BFO:0000050 MBA:1041 ! part of Paraflocculus property_value: IAO:0000028 "PFLpu" xsd:string property_value: skos:prefLabel "Paraflocculus, Purkinje layer ( mouse )" xsd:string [Term] id: MBA:10689 name: Paraflocculus, molecular layer synonym: "PFLmo" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=1#structure=10689 xref: http://atlas.brain-map.org/atlas?atlas=2#structure=10689 xref: http://atlas.brain-map.org/atlas?atlas=602630314#structure=10689 is_a: MBA:1144 ! Cerebellar cortex, molecular layer intersection_of: BFO:0000050 NCBITaxon:10090 {all_some="true"} ! part of Mus musculus intersection_of: BFO:0000050 UBERON:0005351 ! part of paraflocculus relationship: BFO:0000050 MBA:1041 ! part of Paraflocculus property_value: IAO:0000028 "PFLmo" xsd:string property_value: skos:prefLabel "Paraflocculus, molecular layer ( mouse )" xsd:string [Term] id: MBA:10690 name: Flocculus, granular layer synonym: "FLgr" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=1#structure=10690 xref: http://atlas.brain-map.org/atlas?atlas=2#structure=10690 xref: http://atlas.brain-map.org/atlas?atlas=602630314#structure=10690 is_a: MBA:1143 ! Cerebellar cortex, granular layer intersection_of: BFO:0000050 NCBITaxon:10090 {all_some="true"} ! part of Mus musculus intersection_of: BFO:0000050 UBERON:0001063 ! part of flocculus relationship: BFO:0000050 MBA:1049 ! part of Flocculus property_value: IAO:0000028 "FLgr" xsd:string property_value: skos:prefLabel "Flocculus, granular layer ( mouse )" xsd:string [Term] id: MBA:10691 name: Flocculus, Purkinje layer synonym: "FLpu" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=1#structure=10691 xref: http://atlas.brain-map.org/atlas?atlas=2#structure=10691 xref: http://atlas.brain-map.org/atlas?atlas=602630314#structure=10691 is_a: MBA:1145 ! Cerebellar cortex, Purkinje layer intersection_of: BFO:0000050 NCBITaxon:10090 {all_some="true"} ! part of Mus musculus intersection_of: BFO:0000050 UBERON:0001063 ! part of flocculus relationship: BFO:0000050 MBA:1049 ! part of Flocculus property_value: IAO:0000028 "FLpu" xsd:string property_value: skos:prefLabel "Flocculus, Purkinje layer ( mouse )" xsd:string [Term] id: MBA:10692 name: Flocculus, molecular layer synonym: "FLmo" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=1#structure=10692 xref: http://atlas.brain-map.org/atlas?atlas=2#structure=10692 xref: http://atlas.brain-map.org/atlas?atlas=602630314#structure=10692 is_a: MBA:1144 ! Cerebellar cortex, molecular layer intersection_of: BFO:0000050 NCBITaxon:10090 {all_some="true"} ! part of Mus musculus intersection_of: BFO:0000050 UBERON:0001063 ! part of flocculus relationship: BFO:0000050 MBA:1049 ! part of Flocculus property_value: IAO:0000028 "FLmo" xsd:string property_value: skos:prefLabel "Flocculus, molecular layer ( mouse )" xsd:string [Term] id: MBA:107 name: Somatomotor areas, Layer 1 synonym: "MO1" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=1#structure=107 xref: http://atlas.brain-map.org/atlas?atlas=2#structure=107 xref: http://atlas.brain-map.org/atlas?atlas=602630314#structure=107 is_a: MBA:ENTITY is_a: UBERON:0005390 ! cortical layer I intersection_of: BFO:0000050 NCBITaxon:10090 {all_some="true"} ! part of Mus musculus intersection_of: BFO:0000050 UBERON:8440076 ! part of somatomotor area relationship: BFO:0000050 MBA:500 ! part of Somatomotor areas property_value: IAO:0000028 "MO1" xsd:string property_value: skos:prefLabel "Somatomotor areas, Layer 1 ( mouse )" xsd:string [Term] id: MBA:10703 name: Dentate gyrus, molecular layer synonym: "DG-mo" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=1#structure=10703 xref: http://atlas.brain-map.org/atlas?atlas=2#structure=10703 xref: http://atlas.brain-map.org/atlas?atlas=602630314#structure=10703 is_a: MBA:ENTITY is_a: UBERON:0004679 ! dentate gyrus molecular layer intersection_of: UBERON:0004679 ! dentate gyrus molecular layer intersection_of: BFO:0000050 NCBITaxon:10090 ! part of Mus musculus relationship: BFO:0000050 MBA:726 ! part of Dentate gyrus property_value: IAO:0000028 "DG-mo" xsd:string property_value: skos:prefLabel "Dentate gyrus, molecular layer ( mouse )" xsd:string [Term] id: MBA:10704 name: Dentate gyrus, polymorph layer synonym: "DG-po" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=1#structure=10704 xref: http://atlas.brain-map.org/atlas?atlas=2#structure=10704 xref: http://atlas.brain-map.org/atlas?atlas=602630314#structure=10704 is_a: MBA:ENTITY is_a: UBERON:0002928 ! dentate gyrus polymorphic layer intersection_of: UBERON:0002928 ! dentate gyrus polymorphic layer intersection_of: BFO:0000050 NCBITaxon:10090 ! part of Mus musculus relationship: BFO:0000050 MBA:726 ! part of Dentate gyrus property_value: IAO:0000028 "DG-po" xsd:string property_value: skos:prefLabel "Dentate gyrus, polymorph layer ( mouse )" xsd:string [Term] id: MBA:1073 name: Hemispheric regions synonym: "HEM" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=1#structure=1073 xref: http://atlas.brain-map.org/atlas?atlas=2#structure=1073 xref: http://atlas.brain-map.org/atlas?atlas=602630314#structure=1073 is_a: MBA:8 ! Basic cell groups and regions is_a: UBERON:0002245 ! cerebellar hemisphere intersection_of: UBERON:0002245 ! cerebellar hemisphere intersection_of: BFO:0000050 NCBITaxon:10090 ! part of Mus musculus relationship: BFO:0000050 MBA:528 ! part of Cerebellar cortex property_value: IAO:0000028 "HEM" xsd:string property_value: skos:prefLabel "Hemispheric regions ( mouse )" xsd:string [Term] id: MBA:10735 name: Nodulus (X), granular layer synonym: "NODgr" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=1#structure=10735 xref: http://atlas.brain-map.org/atlas?atlas=2#structure=10735 xref: http://atlas.brain-map.org/atlas?atlas=602630314#structure=10735 is_a: MBA:1143 ! Cerebellar cortex, granular layer intersection_of: BFO:0000050 NCBITaxon:10090 {all_some="true"} ! part of Mus musculus intersection_of: BFO:0000050 UBERON:0004083 ! part of cerebellum vermis lobule X relationship: BFO:0000050 MBA:968 ! part of Nodulus (X) property_value: IAO:0000028 "NODgr" xsd:string property_value: skos:prefLabel "Nodulus (X), granular layer ( mouse )" xsd:string [Term] id: MBA:10736 name: Nodulus (X), Purkinje layer synonym: "NODpu" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=1#structure=10736 xref: http://atlas.brain-map.org/atlas?atlas=2#structure=10736 xref: http://atlas.brain-map.org/atlas?atlas=602630314#structure=10736 is_a: MBA:1145 ! Cerebellar cortex, Purkinje layer intersection_of: BFO:0000050 NCBITaxon:10090 {all_some="true"} ! part of Mus musculus intersection_of: BFO:0000050 UBERON:0004083 ! part of cerebellum vermis lobule X relationship: BFO:0000050 MBA:968 ! part of Nodulus (X) property_value: IAO:0000028 "NODpu" xsd:string property_value: skos:prefLabel "Nodulus (X), Purkinje layer ( mouse )" xsd:string [Term] id: MBA:10737 name: Nodulus (X), molecular layer synonym: "NODmo" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=1#structure=10737 xref: http://atlas.brain-map.org/atlas?atlas=2#structure=10737 xref: http://atlas.brain-map.org/atlas?atlas=602630314#structure=10737 is_a: MBA:1144 ! Cerebellar cortex, molecular layer intersection_of: BFO:0000050 NCBITaxon:10090 {all_some="true"} ! part of Mus musculus intersection_of: BFO:0000050 UBERON:0004083 ! part of cerebellum vermis lobule X relationship: BFO:0000050 MBA:968 ! part of Nodulus (X) property_value: IAO:0000028 "NODmo" xsd:string property_value: skos:prefLabel "Nodulus (X), molecular layer ( mouse )" xsd:string [Term] id: MBA:108 name: choroid plexus synonym: "chpl" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=1#structure=108 xref: http://atlas.brain-map.org/atlas?atlas=2#structure=108 xref: http://atlas.brain-map.org/atlas?atlas=602630314#structure=108 is_a: MBA:ENTITY is_a: UBERON:0002200 ! vasculature of head is_a: UBERON:0002307 ! choroid plexus of lateral ventricle intersection_of: UBERON:0001886 ! choroid plexus intersection_of: BFO:0000050 NCBITaxon:10090 ! part of Mus musculus relationship: BFO:0000050 MBA:81 ! part of lateral ventricle property_value: IAO:0000028 "chpl" xsd:string property_value: skos:prefLabel "choroid plexus ( mouse )" xsd:string [Term] id: MBA:1080 name: Hippocampal region synonym: "HIP" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=1#structure=1080 xref: http://atlas.brain-map.org/atlas?atlas=2#structure=1080 xref: http://atlas.brain-map.org/atlas?atlas=602630314#structure=1080 is_a: BFO:0000004 relationship: BFO:0000050 MBA:1089 ! part of Hippocampal formation property_value: IAO:0000028 "HIP" xsd:string property_value: skos:prefLabel "Hippocampal region ( mouse )" xsd:string [Term] id: MBA:1089 name: Hippocampal formation synonym: "HPF" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=1#structure=1089 xref: http://atlas.brain-map.org/atlas?atlas=2#structure=1089 xref: http://atlas.brain-map.org/atlas?atlas=602630314#structure=1089 is_a: MBA:8 ! Basic cell groups and regions is_a: UBERON:0002421 ! hippocampal formation intersection_of: UBERON:0002421 ! hippocampal formation intersection_of: BFO:0000050 NCBITaxon:10090 ! part of Mus musculus relationship: BFO:0000050 MBA:695 ! part of Cortical plate property_value: IAO:0000028 "HPF" xsd:string property_value: skos:prefLabel "Hippocampal formation ( mouse )" xsd:string [Term] id: MBA:1097 name: Hypothalamus synonym: "HY" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=1#structure=1097 xref: http://atlas.brain-map.org/atlas?atlas=2#structure=1097 xref: http://atlas.brain-map.org/atlas?atlas=602630314#structure=1097 is_a: MBA:8 ! Basic cell groups and regions is_a: UBERON:0001898 ! hypothalamus intersection_of: UBERON:0001898 ! hypothalamus intersection_of: BFO:0000050 NCBITaxon:10090 ! part of Mus musculus relationship: BFO:0000050 MBA:1129 ! part of Interbrain property_value: IAO:0000028 "HY" xsd:string property_value: skos:prefLabel "Hypothalamus ( mouse )" xsd:string [Term] id: MBA:1099 name: fornix system synonym: "fxs" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=1#structure=1099 xref: http://atlas.brain-map.org/atlas?atlas=2#structure=1099 xref: http://atlas.brain-map.org/atlas?atlas=602630314#structure=1099 is_a: MBA:1009 ! fiber tracts is_a: UBERON:0000052 ! fornix of brain intersection_of: UBERON:0000052 ! fornix of brain intersection_of: BFO:0000050 NCBITaxon:10090 ! part of Mus musculus relationship: BFO:0000050 MBA:768 ! part of cerebrum related property_value: IAO:0000028 "fxs" xsd:string property_value: skos:prefLabel "fornix system ( mouse )" xsd:string [Term] id: MBA:1100 name: Pretectal region synonym: "PRT" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=1#structure=1100 xref: http://atlas.brain-map.org/atlas?atlas=2#structure=1100 xref: http://atlas.brain-map.org/atlas?atlas=602630314#structure=1100 is_a: MBA:ENTITY is_a: UBERON:0001944 ! pretectal region is_a: UBERON:0019267 ! gray matter of midbrain intersection_of: UBERON:0001944 ! pretectal region intersection_of: BFO:0000050 NCBITaxon:10090 ! part of Mus musculus relationship: BFO:0000050 MBA:323 ! part of Midbrain, motor related property_value: IAO:0000028 "PRT" xsd:string property_value: skos:prefLabel "Pretectal region ( mouse )" xsd:string [Term] id: MBA:1108 name: genu of corpus callosum synonym: "ccg" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=1#structure=1108 xref: http://atlas.brain-map.org/atlas?atlas=2#structure=1108 xref: http://atlas.brain-map.org/atlas?atlas=602630314#structure=1108 is_a: MBA:8 ! Basic cell groups and regions is_a: UBERON:0015599 ! genu of corpus callosum intersection_of: UBERON:0015599 ! genu of corpus callosum intersection_of: BFO:0000050 NCBITaxon:10090 ! part of Mus musculus relationship: BFO:0000050 MBA:776 ! part of corpus callosum property_value: IAO:0000028 "ccg" xsd:string property_value: skos:prefLabel "genu of corpus callosum ( mouse )" xsd:string [Term] id: MBA:1117 name: Pons, behavioral state related synonym: "P-sat" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=1#structure=1117 xref: http://atlas.brain-map.org/atlas?atlas=2#structure=1117 xref: http://atlas.brain-map.org/atlas?atlas=602630314#structure=1117 is_a: BFO:0000004 relationship: BFO:0000050 MBA:771 ! part of Pons property_value: IAO:0000028 "P-sat" xsd:string property_value: skos:prefLabel "Pons, behavioral state related ( mouse )" xsd:string [Term] id: MBA:1129 name: Interbrain synonym: "IB" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=1#structure=1129 xref: http://atlas.brain-map.org/atlas?atlas=2#structure=1129 xref: http://atlas.brain-map.org/atlas?atlas=602630314#structure=1129 is_a: MBA:8 ! Basic cell groups and regions is_a: UBERON:0001894 ! diencephalon intersection_of: UBERON:0001894 ! diencephalon intersection_of: BFO:0000050 NCBITaxon:10090 ! part of Mus musculus relationship: BFO:0000050 MBA:343 ! part of Brain stem property_value: IAO:0000028 "IB" xsd:string property_value: skos:prefLabel "Interbrain ( mouse )" xsd:string [Term] id: MBA:1132 name: Pons, sensory related synonym: "P-sen" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=1#structure=1132 xref: http://atlas.brain-map.org/atlas?atlas=2#structure=1132 xref: http://atlas.brain-map.org/atlas?atlas=602630314#structure=1132 is_a: BFO:0000004 relationship: BFO:0000050 MBA:771 ! part of Pons property_value: IAO:0000028 "P-sen" xsd:string property_value: skos:prefLabel "Pons, sensory related ( mouse )" xsd:string [Term] id: MBA:1143 name: Cerebellar cortex, granular layer synonym: "CBXgr" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=1#structure=1143 xref: http://atlas.brain-map.org/atlas?atlas=2#structure=1143 xref: http://atlas.brain-map.org/atlas?atlas=602630314#structure=1143 is_a: MBA:ENTITY is_a: UBERON:0002956 ! granular layer of cerebellar cortex intersection_of: UBERON:0002956 ! granular layer of cerebellar cortex intersection_of: BFO:0000050 NCBITaxon:10090 ! part of Mus musculus relationship: BFO:0000050 MBA:528 ! part of Cerebellar cortex property_value: IAO:0000028 "CBXgr" xsd:string property_value: skos:prefLabel "Cerebellar cortex, granular layer ( mouse )" xsd:string [Term] id: MBA:1144 name: Cerebellar cortex, molecular layer synonym: "CBXmo" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=1#structure=1144 xref: http://atlas.brain-map.org/atlas?atlas=2#structure=1144 xref: http://atlas.brain-map.org/atlas?atlas=602630314#structure=1144 is_a: MBA:ENTITY is_a: UBERON:0002974 ! molecular layer of cerebellar cortex intersection_of: UBERON:0002974 ! molecular layer of cerebellar cortex intersection_of: BFO:0000050 NCBITaxon:10090 ! part of Mus musculus relationship: BFO:0000050 MBA:528 ! part of Cerebellar cortex property_value: IAO:0000028 "CBXmo" xsd:string property_value: skos:prefLabel "Cerebellar cortex, molecular layer ( mouse )" xsd:string [Term] id: MBA:1145 name: Cerebellar cortex, Purkinje layer synonym: "CBXpu" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=1#structure=1145 xref: http://atlas.brain-map.org/atlas?atlas=2#structure=1145 xref: http://atlas.brain-map.org/atlas?atlas=602630314#structure=1145 is_a: MBA:ENTITY is_a: UBERON:0002979 ! Purkinje cell layer of cerebellar cortex intersection_of: UBERON:0002979 ! Purkinje cell layer of cerebellar cortex intersection_of: BFO:0000050 NCBITaxon:10090 ! part of Mus musculus relationship: BFO:0000050 MBA:528 ! part of Cerebellar cortex property_value: IAO:0000028 "CBXpu" xsd:string property_value: skos:prefLabel "Cerebellar cortex, Purkinje layer ( mouse )" xsd:string [Term] id: MBA:117 name: optic chiasm synonym: "och" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=1#structure=117 xref: http://atlas.brain-map.org/atlas?atlas=2#structure=117 xref: http://atlas.brain-map.org/atlas?atlas=602630314#structure=117 is_a: MBA:1009 ! fiber tracts is_a: UBERON:0000959 ! optic chiasma intersection_of: UBERON:0000959 ! optic chiasma intersection_of: BFO:0000050 NCBITaxon:10090 ! part of Mus musculus relationship: BFO:0000050 MBA:848 ! part of optic nerve property_value: IAO:0000028 "och" xsd:string property_value: skos:prefLabel "optic chiasm ( mouse )" xsd:string [Term] id: MBA:118 name: Periventricular hypothalamic nucleus, intermediate part synonym: "PVi" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=1#structure=118 xref: http://atlas.brain-map.org/atlas?atlas=2#structure=118 xref: http://atlas.brain-map.org/atlas?atlas=602630314#structure=118 is_a: MBA:ENTITY is_a: UBERON:0006331 ! brainstem nucleus is_a: UBERON:8440008 ! periventricular hypothalamic nucleus, intermediate part intersection_of: UBERON:8440008 ! periventricular hypothalamic nucleus, intermediate part intersection_of: BFO:0000050 NCBITaxon:10090 ! part of Mus musculus relationship: BFO:0000050 MBA:157 ! part of Periventricular zone property_value: IAO:0000028 "PVi" xsd:string property_value: skos:prefLabel "Periventricular hypothalamic nucleus, intermediate part ( mouse )" xsd:string [Term] id: MBA:125 name: optic tract synonym: "opt" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=1#structure=125 xref: http://atlas.brain-map.org/atlas?atlas=2#structure=125 xref: http://atlas.brain-map.org/atlas?atlas=602630314#structure=125 is_a: MBA:1009 ! fiber tracts is_a: UBERON:0001908 ! optic tract intersection_of: UBERON:0001908 ! optic tract intersection_of: BFO:0000050 NCBITaxon:10090 ! part of Mus musculus relationship: BFO:0000050 MBA:848 ! part of optic nerve property_value: IAO:0000028 "opt" xsd:string property_value: skos:prefLabel "optic tract ( mouse )" xsd:string [Term] id: MBA:126 name: Periventricular hypothalamic nucleus, posterior part synonym: "PVp" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=1#structure=126 xref: http://atlas.brain-map.org/atlas?atlas=2#structure=126 xref: http://atlas.brain-map.org/atlas?atlas=602630314#structure=126 is_a: MBA:ENTITY is_a: UBERON:0002708 ! posterior periventricular nucleus is_a: UBERON:0006331 ! brainstem nucleus intersection_of: UBERON:0002708 ! posterior periventricular nucleus intersection_of: BFO:0000050 NCBITaxon:10090 ! part of Mus musculus relationship: BFO:0000050 MBA:141 ! part of Periventricular region property_value: IAO:0000028 "PVp" xsd:string property_value: skos:prefLabel "Periventricular hypothalamic nucleus, posterior part ( mouse )" xsd:string [Term] id: MBA:128 name: Midbrain reticular nucleus synonym: "MRN" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=1#structure=128 xref: http://atlas.brain-map.org/atlas?atlas=2#structure=128 xref: http://atlas.brain-map.org/atlas?atlas=602630314#structure=128 is_a: MBA:ENTITY is_a: UBERON:0007415 ! nucleus of midbrain reticular formation intersection_of: UBERON:0007415 ! nucleus of midbrain reticular formation intersection_of: BFO:0000050 NCBITaxon:10090 ! part of Mus musculus relationship: BFO:0000050 MBA:323 ! part of Midbrain, motor related property_value: IAO:0000028 "MRN" xsd:string property_value: skos:prefLabel "Midbrain reticular nucleus ( mouse )" xsd:string [Term] id: MBA:129 name: third ventricle synonym: "V3" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=1#structure=129 xref: http://atlas.brain-map.org/atlas?atlas=2#structure=129 xref: http://atlas.brain-map.org/atlas?atlas=602630314#structure=129 is_a: MBA:ENTITY is_a: UBERON:0002286 ! third ventricle intersection_of: UBERON:0002286 ! third ventricle intersection_of: BFO:0000050 NCBITaxon:10090 ! part of Mus musculus relationship: BFO:0000050 MBA:73 ! part of ventricular systems property_value: IAO:0000028 "V3" xsd:string property_value: skos:prefLabel "third ventricle ( mouse )" xsd:string [Term] id: MBA:131 name: Lateral amygdalar nucleus synonym: "LA" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=1#structure=131 xref: http://atlas.brain-map.org/atlas?atlas=2#structure=131 xref: http://atlas.brain-map.org/atlas?atlas=602630314#structure=131 is_a: MBA:ENTITY is_a: UBERON:0002886 ! lateral amygdaloid nucleus intersection_of: UBERON:0002886 ! lateral amygdaloid nucleus intersection_of: BFO:0000050 NCBITaxon:10090 ! part of Mus musculus relationship: BFO:0000050 MBA:703 ! part of Cortical subplate property_value: IAO:0000028 "LA" xsd:string property_value: skos:prefLabel "Lateral amygdalar nucleus ( mouse )" xsd:string [Term] id: MBA:133 name: Periventricular hypothalamic nucleus, preoptic part synonym: "PVpo" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=1#structure=133 xref: http://atlas.brain-map.org/atlas?atlas=2#structure=133 xref: http://atlas.brain-map.org/atlas?atlas=602630314#structure=133 is_a: MBA:ENTITY is_a: UBERON:0002622 ! preoptic periventricular nucleus is_a: UBERON:0006331 ! brainstem nucleus is_a: UBERON:0006568 ! hypothalamic nucleus intersection_of: UBERON:0002622 ! preoptic periventricular nucleus intersection_of: BFO:0000050 NCBITaxon:10090 ! part of Mus musculus relationship: BFO:0000050 MBA:141 ! part of Periventricular region property_value: IAO:0000028 "PVpo" xsd:string property_value: skos:prefLabel "Periventricular hypothalamic nucleus, preoptic part ( mouse )" xsd:string [Term] id: MBA:138 name: Lateral group of the dorsal thalamus synonym: "LAT" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=1#structure=138 xref: http://atlas.brain-map.org/atlas?atlas=2#structure=138 xref: http://atlas.brain-map.org/atlas?atlas=602630314#structure=138 is_a: MBA:ENTITY is_a: UBERON:0002736 ! lateral nuclear group of thalamus is_a: UBERON:0006331 ! brainstem nucleus intersection_of: UBERON:0002736 ! lateral nuclear group of thalamus intersection_of: BFO:0000050 NCBITaxon:10090 ! part of Mus musculus relationship: BFO:0000050 MBA:856 ! part of Thalamus, polymodal association cortex related property_value: IAO:0000028 "LAT" xsd:string property_value: skos:prefLabel "Lateral group of the dorsal thalamus ( mouse )" xsd:string [Term] id: MBA:141 name: Periventricular region synonym: "PVR" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=1#structure=141 xref: http://atlas.brain-map.org/atlas?atlas=2#structure=141 xref: http://atlas.brain-map.org/atlas?atlas=602630314#structure=141 is_a: BFO:0000004 relationship: BFO:0000050 MBA:1097 ! part of Hypothalamus property_value: IAO:0000028 "PVR" xsd:string property_value: skos:prefLabel "Periventricular region ( mouse )" xsd:string [Term] id: MBA:145 name: fourth ventricle synonym: "V4" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=1#structure=145 xref: http://atlas.brain-map.org/atlas?atlas=2#structure=145 xref: http://atlas.brain-map.org/atlas?atlas=602630314#structure=145 is_a: MBA:ENTITY is_a: UBERON:0002422 ! fourth ventricle intersection_of: UBERON:0002422 ! fourth ventricle intersection_of: BFO:0000050 NCBITaxon:10090 ! part of Mus musculus relationship: BFO:0000050 MBA:73 ! part of ventricular systems property_value: IAO:0000028 "V4" xsd:string property_value: skos:prefLabel "fourth ventricle ( mouse )" xsd:string [Term] id: MBA:147 name: Locus ceruleus synonym: "LC" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=1#structure=147 xref: http://atlas.brain-map.org/atlas?atlas=2#structure=147 xref: http://atlas.brain-map.org/atlas?atlas=602630314#structure=147 is_a: MBA:8 ! Basic cell groups and regions is_a: UBERON:0002148 ! locus ceruleus intersection_of: UBERON:0002148 ! locus ceruleus intersection_of: BFO:0000050 NCBITaxon:10090 ! part of Mus musculus relationship: BFO:0000050 MBA:1117 ! part of Pons, behavioral state related property_value: IAO:0000028 "LC" xsd:string property_value: skos:prefLabel "Locus ceruleus ( mouse )" xsd:string [Term] id: MBA:157 name: Periventricular zone synonym: "PVZ" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=1#structure=157 xref: http://atlas.brain-map.org/atlas?atlas=2#structure=157 xref: http://atlas.brain-map.org/atlas?atlas=602630314#structure=157 is_a: MBA:ENTITY is_a: UBERON:0002271 ! periventricular zone of hypothalamus intersection_of: UBERON:0002271 ! periventricular zone of hypothalamus intersection_of: BFO:0000050 NCBITaxon:10090 ! part of Mus musculus relationship: BFO:0000050 MBA:1097 ! part of Hypothalamus property_value: IAO:0000028 "PVZ" xsd:string property_value: skos:prefLabel "Periventricular zone ( mouse )" xsd:string [Term] id: MBA:158 name: posterior commissure synonym: "pc" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=1#structure=158 xref: http://atlas.brain-map.org/atlas?atlas=2#structure=158 xref: http://atlas.brain-map.org/atlas?atlas=602630314#structure=158 is_a: MBA:1009 ! fiber tracts is_a: UBERON:0000936 ! posterior commissure intersection_of: UBERON:0000936 ! posterior commissure intersection_of: BFO:0000050 NCBITaxon:10090 ! part of Mus musculus relationship: BFO:0000050 MBA:832 ! part of oculomotor nerve property_value: IAO:0000028 "pc" xsd:string property_value: skos:prefLabel "posterior commissure ( mouse )" xsd:string [Term] id: MBA:159 name: Anterior olfactory nucleus synonym: "AON" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=1#structure=159 xref: http://atlas.brain-map.org/atlas?atlas=2#structure=159 xref: http://atlas.brain-map.org/atlas?atlas=602630314#structure=159 is_a: MBA:ENTITY is_a: UBERON:0002266 ! anterior olfactory nucleus intersection_of: UBERON:0002266 ! anterior olfactory nucleus intersection_of: BFO:0000050 NCBITaxon:10090 ! part of Mus musculus relationship: BFO:0000050 MBA:698 ! part of Olfactory areas property_value: IAO:0000028 "AON" xsd:string property_value: skos:prefLabel "Anterior olfactory nucleus ( mouse )" xsd:string [Term] id: MBA:164 name: central canal, spinal cord/medulla synonym: "c" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=1#structure=164 xref: http://atlas.brain-map.org/atlas?atlas=2#structure=164 xref: http://atlas.brain-map.org/atlas?atlas=602630314#structure=164 is_a: MBA:ENTITY is_a: UBERON:0002291 ! central canal of spinal cord intersection_of: UBERON:0002291 ! central canal of spinal cord intersection_of: BFO:0000050 NCBITaxon:10090 ! part of Mus musculus relationship: BFO:0000050 MBA:73 ! part of ventricular systems property_value: IAO:0000028 "c" xsd:string property_value: skos:prefLabel "central canal, spinal cord/medulla ( mouse )" xsd:string [Term] id: MBA:170 name: Dorsal part of the lateral geniculate complex synonym: "LGd" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=1#structure=170 xref: http://atlas.brain-map.org/atlas?atlas=2#structure=170 xref: http://atlas.brain-map.org/atlas?atlas=602630314#structure=170 is_a: MBA:ENTITY is_a: UBERON:0002479 ! dorsal lateral geniculate nucleus is_a: UBERON:0006331 ! brainstem nucleus intersection_of: UBERON:0002479 ! dorsal lateral geniculate nucleus intersection_of: BFO:0000050 NCBITaxon:10090 ! part of Mus musculus relationship: BFO:0000050 MBA:1008 ! part of Geniculate group, dorsal thalamus property_value: IAO:0000028 "LGd" xsd:string property_value: skos:prefLabel "Dorsal part of the lateral geniculate complex ( mouse )" xsd:string [Term] id: MBA:207 name: Area postrema synonym: "AP" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=1#structure=207 xref: http://atlas.brain-map.org/atlas?atlas=2#structure=207 xref: http://atlas.brain-map.org/atlas?atlas=602630314#structure=207 is_a: MBA:8 ! Basic cell groups and regions is_a: UBERON:0002162 ! area postrema intersection_of: UBERON:0002162 ! area postrema intersection_of: BFO:0000050 NCBITaxon:10090 ! part of Mus musculus relationship: BFO:0000050 MBA:386 ! part of Medulla, sensory related property_value: IAO:0000028 "AP" xsd:string property_value: skos:prefLabel "Area postrema ( mouse )" xsd:string [Term] id: MBA:21 name: lateral olfactory tract, general synonym: "lotg" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=1#structure=21 xref: http://atlas.brain-map.org/atlas?atlas=2#structure=21 xref: http://atlas.brain-map.org/atlas?atlas=602630314#structure=21 is_a: BFO:0000004 relationship: BFO:0000050 MBA:840 ! part of olfactory nerve property_value: IAO:0000028 "lotg" xsd:string property_value: skos:prefLabel "lateral olfactory tract, general ( mouse )" xsd:string [Term] id: MBA:212 name: Main olfactory bulb, glomerular layer synonym: "MOBgl" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=1#structure=212 xref: http://atlas.brain-map.org/atlas?atlas=2#structure=212 xref: http://atlas.brain-map.org/atlas?atlas=602630314#structure=212 is_a: MBA:ENTITY is_a: UBERON:0023934 ! olfactory bulb main glomerular layer intersection_of: UBERON:0005377 ! olfactory bulb glomerular layer intersection_of: BFO:0000050 NCBITaxon:10090 ! part of Mus musculus relationship: BFO:0000050 MBA:507 ! part of Main olfactory bulb property_value: IAO:0000028 "MOBgl" xsd:string property_value: skos:prefLabel "Main olfactory bulb, glomerular layer ( mouse )" xsd:string [Term] id: MBA:219 name: Somatomotor areas, Layer 2/3 synonym: "MO2/3" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=1#structure=219 xref: http://atlas.brain-map.org/atlas?atlas=2#structure=219 xref: http://atlas.brain-map.org/atlas?atlas=602630314#structure=219 is_a: MBA:ENTITY is_a: UBERON:8440000 ! cortical layer II/III intersection_of: BFO:0000050 NCBITaxon:10090 {all_some="true"} ! part of Mus musculus intersection_of: BFO:0000050 UBERON:8440076 ! part of somatomotor area relationship: BFO:0000050 MBA:500 ! part of Somatomotor areas property_value: IAO:0000028 "MO2/3" xsd:string property_value: skos:prefLabel "Somatomotor areas, Layer 2/3 ( mouse )" xsd:string [Term] id: MBA:220 name: Main olfactory bulb, granule layer synonym: "MOBgr" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=1#structure=220 xref: http://atlas.brain-map.org/atlas?atlas=2#structure=220 xref: http://atlas.brain-map.org/atlas?atlas=602630314#structure=220 is_a: MBA:ENTITY is_a: UBERON:0005378 ! olfactory bulb granule cell layer intersection_of: UBERON:0005378 ! olfactory bulb granule cell layer intersection_of: BFO:0000050 NCBITaxon:10090 ! part of Mus musculus relationship: BFO:0000050 MBA:507 ! part of Main olfactory bulb property_value: IAO:0000028 "MOBgr" xsd:string property_value: skos:prefLabel "Main olfactory bulb, granule layer ( mouse )" xsd:string [Term] id: MBA:223 name: Arcuate hypothalamic nucleus synonym: "ARH" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=1#structure=223 xref: http://atlas.brain-map.org/atlas?atlas=2#structure=223 xref: http://atlas.brain-map.org/atlas?atlas=602630314#structure=223 is_a: MBA:ENTITY is_a: UBERON:0001932 ! arcuate nucleus of hypothalamus is_a: UBERON:0006331 ! brainstem nucleus intersection_of: UBERON:0001932 ! arcuate nucleus of hypothalamus intersection_of: BFO:0000050 NCBITaxon:10090 ! part of Mus musculus relationship: BFO:0000050 MBA:157 ! part of Periventricular zone property_value: IAO:0000028 "ARH" xsd:string property_value: skos:prefLabel "Arcuate hypothalamic nucleus ( mouse )" xsd:string [Term] id: MBA:236 name: Main olfactory bulb, mitral layer synonym: "MOBmi" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=1#structure=236 xref: http://atlas.brain-map.org/atlas?atlas=2#structure=236 xref: http://atlas.brain-map.org/atlas?atlas=602630314#structure=236 is_a: MBA:ENTITY is_a: UBERON:0004186 ! olfactory bulb mitral cell layer intersection_of: UBERON:0004186 ! olfactory bulb mitral cell layer intersection_of: BFO:0000050 NCBITaxon:10090 ! part of Mus musculus relationship: BFO:0000050 MBA:507 ! part of Main olfactory bulb property_value: IAO:0000028 "MOBmi" xsd:string property_value: skos:prefLabel "Main olfactory bulb, mitral layer ( mouse )" xsd:string [Term] id: MBA:238 name: Nucleus raphe pontis synonym: "RPO" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=1#structure=238 xref: http://atlas.brain-map.org/atlas?atlas=2#structure=238 xref: http://atlas.brain-map.org/atlas?atlas=602630314#structure=238 is_a: MBA:ENTITY is_a: UBERON:0002047 ! pontine raphe nucleus intersection_of: UBERON:0002047 ! pontine raphe nucleus intersection_of: BFO:0000050 NCBITaxon:10090 ! part of Mus musculus relationship: BFO:0000050 MBA:1117 ! part of Pons, behavioral state related property_value: IAO:0000028 "RPO" xsd:string property_value: skos:prefLabel "Nucleus raphe pontis ( mouse )" xsd:string [Term] id: MBA:242 name: Lateral septal nucleus synonym: "LS" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=1#structure=242 xref: http://atlas.brain-map.org/atlas?atlas=2#structure=242 xref: http://atlas.brain-map.org/atlas?atlas=602630314#structure=242 is_a: MBA:ENTITY is_a: UBERON:0002667 ! lateral septal nucleus intersection_of: UBERON:0002667 ! lateral septal nucleus intersection_of: BFO:0000050 NCBITaxon:10090 ! part of Mus musculus relationship: BFO:0000050 MBA:275 ! part of Lateral septal complex property_value: IAO:0000028 "LS" xsd:string property_value: skos:prefLabel "Lateral septal nucleus ( mouse )" xsd:string [Term] id: MBA:244 name: Main olfactory bulb, outer plexiform layer synonym: "MOBopl" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=1#structure=244 xref: http://atlas.brain-map.org/atlas?atlas=2#structure=244 xref: http://atlas.brain-map.org/atlas?atlas=602630314#structure=244 is_a: BFO:0000004 relationship: BFO:0000050 MBA:507 ! part of Main olfactory bulb relationship: BFO:0000050 NCBITaxon:10090 ! part of Mus musculus relationship: BFO:0000050 UBERON:0005376 ! part of olfactory bulb external plexiform layer property_value: IAO:0000028 "MOBopl" xsd:string property_value: skos:prefLabel "Main olfactory bulb, outer plexiform layer ( mouse )" xsd:string [Term] id: MBA:246 name: Midbrain reticular nucleus, retrorubral area synonym: "RR" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=1#structure=246 xref: http://atlas.brain-map.org/atlas?atlas=2#structure=246 xref: http://atlas.brain-map.org/atlas?atlas=602630314#structure=246 is_a: MBA:8 ! Basic cell groups and regions is_a: UBERON:0011172 ! retrorubral area of midbrain reticular nucleus intersection_of: UBERON:0011172 ! retrorubral area of midbrain reticular nucleus intersection_of: BFO:0000050 NCBITaxon:10090 ! part of Mus musculus relationship: BFO:0000050 MBA:323 ! part of Midbrain, motor related property_value: IAO:0000028 "RR" xsd:string property_value: skos:prefLabel "Midbrain reticular nucleus, retrorubral area ( mouse )" xsd:string [Term] id: MBA:258 name: Lateral septal nucleus, rostral (rostroventral) part synonym: "LSr" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=1#structure=258 xref: http://atlas.brain-map.org/atlas?atlas=2#structure=258 xref: http://atlas.brain-map.org/atlas?atlas=602630314#structure=258 is_a: BFO:0000004 relationship: BFO:0000050 MBA:242 ! part of Lateral septal nucleus property_value: IAO:0000028 "LSr" xsd:string property_value: skos:prefLabel "Lateral septal nucleus, rostral (rostroventral) part ( mouse )" xsd:string [Term] id: MBA:272 name: Anteroventral periventricular nucleus synonym: "AVPV" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=1#structure=272 xref: http://atlas.brain-map.org/atlas?atlas=2#structure=272 xref: http://atlas.brain-map.org/atlas?atlas=602630314#structure=272 is_a: MBA:ENTITY is_a: UBERON:0002690 ! anteroventral periventricular nucleus is_a: UBERON:0006331 ! brainstem nucleus intersection_of: UBERON:0002690 ! anteroventral periventricular nucleus intersection_of: BFO:0000050 NCBITaxon:10090 ! part of Mus musculus relationship: BFO:0000050 MBA:141 ! part of Periventricular region property_value: IAO:0000028 "AVPV" xsd:string property_value: skos:prefLabel "Anteroventral periventricular nucleus ( mouse )" xsd:string [Term] id: MBA:275 name: Lateral septal complex synonym: "LSX" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=1#structure=275 xref: http://atlas.brain-map.org/atlas?atlas=2#structure=275 xref: http://atlas.brain-map.org/atlas?atlas=602630314#structure=275 is_a: MBA:ENTITY is_a: UBERON:0007628 ! lateral septal complex intersection_of: UBERON:0007628 ! lateral septal complex intersection_of: BFO:0000050 NCBITaxon:10090 ! part of Mus musculus relationship: BFO:0000050 MBA:477 ! part of Striatum property_value: IAO:0000028 "LSX" xsd:string property_value: skos:prefLabel "Lateral septal complex ( mouse )" xsd:string [Term] id: MBA:278 name: Striatum-like amygdalar nuclei synonym: "sAMY" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=1#structure=278 xref: http://atlas.brain-map.org/atlas?atlas=2#structure=278 xref: http://atlas.brain-map.org/atlas?atlas=602630314#structure=278 is_a: MBA:ENTITY is_a: UBERON:8440030 ! striatum-like amygdalar nuclei intersection_of: UBERON:8440030 ! striatum-like amygdalar nuclei intersection_of: BFO:0000050 NCBITaxon:10090 ! part of Mus musculus relationship: BFO:0000050 MBA:477 ! part of Striatum property_value: IAO:0000028 "sAMY" xsd:string property_value: skos:prefLabel "Striatum-like amygdalar nuclei ( mouse )" xsd:string [Term] id: MBA:286 name: Suprachiasmatic nucleus synonym: "SCH" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=1#structure=286 xref: http://atlas.brain-map.org/atlas?atlas=2#structure=286 xref: http://atlas.brain-map.org/atlas?atlas=602630314#structure=286 is_a: MBA:ENTITY is_a: UBERON:0002034 ! suprachiasmatic nucleus is_a: UBERON:0006331 ! brainstem nucleus intersection_of: UBERON:0002034 ! suprachiasmatic nucleus intersection_of: BFO:0000050 NCBITaxon:10090 ! part of Mus musculus relationship: BFO:0000050 MBA:141 ! part of Periventricular region property_value: IAO:0000028 "SCH" xsd:string property_value: skos:prefLabel "Suprachiasmatic nucleus ( mouse )" xsd:string [Term] id: MBA:290 name: Hypothalamic lateral zone synonym: "LZ" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=1#structure=290 xref: http://atlas.brain-map.org/atlas?atlas=2#structure=290 xref: http://atlas.brain-map.org/atlas?atlas=602630314#structure=290 is_a: MBA:ENTITY is_a: UBERON:0002273 ! lateral zone of hypothalamus intersection_of: UBERON:0002273 ! lateral zone of hypothalamus intersection_of: BFO:0000050 NCBITaxon:10090 ! part of Mus musculus relationship: BFO:0000050 MBA:1097 ! part of Hypothalamus property_value: IAO:0000028 "LZ" xsd:string property_value: skos:prefLabel "Hypothalamic lateral zone ( mouse )" xsd:string [Term] id: MBA:304325711 name: retina synonym: "retina" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=1#structure=304325711 xref: http://atlas.brain-map.org/atlas?atlas=2#structure=304325711 xref: http://atlas.brain-map.org/atlas?atlas=602630314#structure=304325711 is_a: MBA:ENTITY is_a: UBERON:0000966 ! retina intersection_of: UBERON:0000966 ! retina intersection_of: BFO:0000050 NCBITaxon:10090 ! part of Mus musculus relationship: BFO:0000050 MBA:997 ! part of brain property_value: IAO:0000028 "retina" xsd:string property_value: skos:prefLabel "retina ( mouse )" xsd:string [Term] id: MBA:313 name: Midbrain synonym: "MB" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=1#structure=313 xref: http://atlas.brain-map.org/atlas?atlas=2#structure=313 xref: http://atlas.brain-map.org/atlas?atlas=602630314#structure=313 is_a: MBA:8 ! Basic cell groups and regions is_a: UBERON:0001891 ! midbrain intersection_of: UBERON:0001891 ! midbrain intersection_of: BFO:0000050 NCBITaxon:10090 ! part of Mus musculus relationship: BFO:0000050 MBA:343 ! part of Brain stem property_value: IAO:0000028 "MB" xsd:string property_value: skos:prefLabel "Midbrain ( mouse )" xsd:string [Term] id: MBA:315 name: Isocortex synonym: "Isocortex" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=1#structure=315 xref: http://atlas.brain-map.org/atlas?atlas=2#structure=315 xref: http://atlas.brain-map.org/atlas?atlas=602630314#structure=315 is_a: MBA:8 ! Basic cell groups and regions is_a: UBERON:0001950 ! neocortex intersection_of: UBERON:0001950 ! neocortex intersection_of: BFO:0000050 NCBITaxon:10090 ! part of Mus musculus relationship: BFO:0000050 MBA:695 ! part of Cortical plate property_value: IAO:0000028 "Isocortex" xsd:string property_value: skos:prefLabel "Isocortex ( mouse )" xsd:string [Term] id: MBA:323 name: Midbrain, motor related synonym: "MBmot" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=1#structure=323 xref: http://atlas.brain-map.org/atlas?atlas=2#structure=323 xref: http://atlas.brain-map.org/atlas?atlas=602630314#structure=323 is_a: BFO:0000004 relationship: BFO:0000050 MBA:313 ! part of Midbrain property_value: IAO:0000028 "MBmot" xsd:string property_value: skos:prefLabel "Midbrain, motor related ( mouse )" xsd:string [Term] id: MBA:331 name: Mammillary body synonym: "MBO" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=1#structure=331 xref: http://atlas.brain-map.org/atlas?atlas=2#structure=331 xref: http://atlas.brain-map.org/atlas?atlas=602630314#structure=331 is_a: MBA:ENTITY is_a: UBERON:0002206 ! mammillary body intersection_of: UBERON:0002206 ! mammillary body intersection_of: BFO:0000050 NCBITaxon:10090 ! part of Mus musculus relationship: BFO:0000050 MBA:467 ! part of Hypothalamic medial zone property_value: IAO:0000028 "MBO" xsd:string property_value: skos:prefLabel "Mammillary body ( mouse )" xsd:string [Term] id: MBA:338 name: Subfornical organ synonym: "SFO" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=1#structure=338 xref: http://atlas.brain-map.org/atlas?atlas=2#structure=338 xref: http://atlas.brain-map.org/atlas?atlas=602630314#structure=338 is_a: MBA:8 ! Basic cell groups and regions is_a: UBERON:0002219 ! subfornical organ intersection_of: UBERON:0002219 ! subfornical organ intersection_of: BFO:0000050 NCBITaxon:10090 ! part of Mus musculus relationship: BFO:0000050 MBA:141 ! part of Periventricular region property_value: IAO:0000028 "SFO" xsd:string property_value: skos:prefLabel "Subfornical organ ( mouse )" xsd:string [Term] id: MBA:339 name: Midbrain, sensory related synonym: "MBsen" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=1#structure=339 xref: http://atlas.brain-map.org/atlas?atlas=2#structure=339 xref: http://atlas.brain-map.org/atlas?atlas=602630314#structure=339 is_a: BFO:0000004 relationship: BFO:0000050 MBA:313 ! part of Midbrain property_value: IAO:0000028 "MBsen" xsd:string property_value: skos:prefLabel "Midbrain, sensory related ( mouse )" xsd:string [Term] id: MBA:343 name: Brain stem synonym: "BS" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=1#structure=343 xref: http://atlas.brain-map.org/atlas?atlas=2#structure=343 xref: http://atlas.brain-map.org/atlas?atlas=602630314#structure=343 is_a: MBA:8 ! Basic cell groups and regions is_a: UBERON:0002298 ! brainstem intersection_of: UBERON:0002298 ! brainstem intersection_of: BFO:0000050 NCBITaxon:10090 ! part of Mus musculus relationship: BFO:0000050 MBA:8 ! part of Basic cell groups and regions property_value: IAO:0000028 "BS" xsd:string property_value: skos:prefLabel "Brain stem ( mouse )" xsd:string [Term] id: MBA:348 name: Midbrain, behavioral state related synonym: "MBsta" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=1#structure=348 xref: http://atlas.brain-map.org/atlas?atlas=2#structure=348 xref: http://atlas.brain-map.org/atlas?atlas=602630314#structure=348 is_a: BFO:0000004 relationship: BFO:0000050 MBA:313 ! part of Midbrain property_value: IAO:0000028 "MBsta" xsd:string property_value: skos:prefLabel "Midbrain, behavioral state related ( mouse )" xsd:string [Term] id: MBA:35 name: Oculomotor nucleus synonym: "III" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=1#structure=35 xref: http://atlas.brain-map.org/atlas?atlas=2#structure=35 xref: http://atlas.brain-map.org/atlas?atlas=602630314#structure=35 is_a: MBA:ENTITY is_a: UBERON:0001715 ! oculomotor nuclear complex intersection_of: UBERON:0001715 ! oculomotor nuclear complex intersection_of: BFO:0000050 NCBITaxon:10090 ! part of Mus musculus relationship: BFO:0000050 MBA:323 ! part of Midbrain, motor related property_value: IAO:0000028 "III" xsd:string property_value: skos:prefLabel "Oculomotor nucleus ( mouse )" xsd:string [Term] id: MBA:354 name: Medulla synonym: "MY" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=1#structure=354 xref: http://atlas.brain-map.org/atlas?atlas=2#structure=354 xref: http://atlas.brain-map.org/atlas?atlas=602630314#structure=354 is_a: MBA:ENTITY is_a: UBERON:0001896 ! medulla oblongata intersection_of: UBERON:0001896 ! medulla oblongata intersection_of: BFO:0000050 NCBITaxon:10090 ! part of Mus musculus relationship: BFO:0000050 MBA:1065 ! part of Hindbrain property_value: IAO:0000028 "MY" xsd:string property_value: skos:prefLabel "Medulla ( mouse )" xsd:string [Term] id: MBA:365 name: thalamic peduncles synonym: "tp" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=1#structure=365 xref: http://atlas.brain-map.org/atlas?atlas=2#structure=365 xref: http://atlas.brain-map.org/atlas?atlas=602630314#structure=365 is_a: MBA:ENTITY is_a: UBERON:0022236 ! peduncle of thalamus intersection_of: UBERON:0022236 ! peduncle of thalamus intersection_of: BFO:0000050 NCBITaxon:10090 ! part of Mus musculus relationship: BFO:0000050 MBA:896 ! part of thalamus related property_value: IAO:0000028 "tp" xsd:string property_value: skos:prefLabel "thalamic peduncles ( mouse )" xsd:string [Term] id: MBA:370 name: Medulla, motor related synonym: "MY-mot" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=1#structure=370 xref: http://atlas.brain-map.org/atlas?atlas=2#structure=370 xref: http://atlas.brain-map.org/atlas?atlas=602630314#structure=370 is_a: BFO:0000004 relationship: BFO:0000050 MBA:354 ! part of Medulla property_value: IAO:0000028 "MY-mot" xsd:string property_value: skos:prefLabel "Medulla, motor related ( mouse )" xsd:string [Term] id: MBA:375 name: Ammon's horn synonym: "CA" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=1#structure=375 xref: http://atlas.brain-map.org/atlas?atlas=2#structure=375 xref: http://atlas.brain-map.org/atlas?atlas=602630314#structure=375 is_a: MBA:8 ! Basic cell groups and regions is_a: UBERON:0001954 ! Ammon's horn intersection_of: UBERON:0001954 ! Ammon's horn intersection_of: BFO:0000050 NCBITaxon:10090 ! part of Mus musculus relationship: BFO:0000050 MBA:1080 ! part of Hippocampal region property_value: IAO:0000028 "CA" xsd:string property_value: skos:prefLabel "Ammon's horn ( mouse )" xsd:string [Term] id: MBA:38 name: Paraventricular hypothalamic nucleus synonym: "PVH" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=1#structure=38 xref: http://atlas.brain-map.org/atlas?atlas=2#structure=38 xref: http://atlas.brain-map.org/atlas?atlas=602630314#structure=38 is_a: MBA:ENTITY is_a: UBERON:0001930 ! paraventricular nucleus of hypothalamus is_a: UBERON:0006331 ! brainstem nucleus intersection_of: UBERON:0001930 ! paraventricular nucleus of hypothalamus intersection_of: BFO:0000050 NCBITaxon:10090 ! part of Mus musculus relationship: BFO:0000050 MBA:157 ! part of Periventricular zone property_value: IAO:0000028 "PVH" xsd:string property_value: skos:prefLabel "Paraventricular hypothalamic nucleus ( mouse )" xsd:string [Term] id: MBA:386 name: Medulla, sensory related synonym: "MY-sen" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=1#structure=386 xref: http://atlas.brain-map.org/atlas?atlas=2#structure=386 xref: http://atlas.brain-map.org/atlas?atlas=602630314#structure=386 is_a: BFO:0000004 relationship: BFO:0000050 MBA:354 ! part of Medulla property_value: IAO:0000028 "MY-sen" xsd:string property_value: skos:prefLabel "Medulla, sensory related ( mouse )" xsd:string [Term] id: MBA:397 name: ventral tegmental decussation synonym: "vtd" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=1#structure=397 xref: http://atlas.brain-map.org/atlas?atlas=2#structure=397 xref: http://atlas.brain-map.org/atlas?atlas=602630314#structure=397 is_a: MBA:1009 ! fiber tracts is_a: UBERON:0002615 ! ventral tegmental decussation intersection_of: UBERON:0002615 ! ventral tegmental decussation intersection_of: BFO:0000050 NCBITaxon:10090 ! part of Mus musculus relationship: BFO:0000050 MBA:863 ! part of rubrospinal tract property_value: IAO:0000028 "vtd" xsd:string property_value: skos:prefLabel "ventral tegmental decussation ( mouse )" xsd:string [Term] id: MBA:398 name: Superior olivary complex synonym: "SOC" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=1#structure=398 xref: http://atlas.brain-map.org/atlas?atlas=2#structure=398 xref: http://atlas.brain-map.org/atlas?atlas=602630314#structure=398 is_a: MBA:ENTITY is_a: UBERON:0002128 ! superior olivary complex intersection_of: UBERON:0002128 ! superior olivary complex intersection_of: BFO:0000050 NCBITaxon:10090 ! part of Mus musculus relationship: BFO:0000050 MBA:1132 ! part of Pons, sensory related property_value: IAO:0000028 "SOC" xsd:string property_value: skos:prefLabel "Superior olivary complex ( mouse )" xsd:string [Term] id: MBA:403 name: Medial amygdalar nucleus synonym: "MEA" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=1#structure=403 xref: http://atlas.brain-map.org/atlas?atlas=2#structure=403 xref: http://atlas.brain-map.org/atlas?atlas=602630314#structure=403 is_a: MBA:ENTITY is_a: UBERON:0002892 ! medial amygdaloid nucleus intersection_of: UBERON:0002892 ! medial amygdaloid nucleus intersection_of: BFO:0000050 NCBITaxon:10090 ! part of Mus musculus relationship: BFO:0000050 MBA:278 ! part of Striatum-like amygdalar nuclei property_value: IAO:0000028 "MEA" xsd:string property_value: skos:prefLabel "Medial amygdalar nucleus ( mouse )" xsd:string [Term] id: MBA:452 name: Median preoptic nucleus synonym: "MEPO" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=1#structure=452 xref: http://atlas.brain-map.org/atlas?atlas=2#structure=452 xref: http://atlas.brain-map.org/atlas?atlas=602630314#structure=452 is_a: MBA:ENTITY is_a: UBERON:0002625 ! median preoptic nucleus is_a: UBERON:0006331 ! brainstem nucleus is_a: UBERON:0006568 ! hypothalamic nucleus intersection_of: UBERON:0002625 ! median preoptic nucleus intersection_of: BFO:0000050 NCBITaxon:10090 ! part of Mus musculus relationship: BFO:0000050 MBA:141 ! part of Periventricular region property_value: IAO:0000028 "MEPO" xsd:string property_value: skos:prefLabel "Median preoptic nucleus ( mouse )" xsd:string [Term] id: MBA:462 name: Superior salivatory nucleus synonym: "SSN" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=1#structure=462 xref: http://atlas.brain-map.org/atlas?atlas=2#structure=462 xref: http://atlas.brain-map.org/atlas?atlas=602630314#structure=462 is_a: MBA:ENTITY is_a: UBERON:0002149 ! superior salivatory nucleus intersection_of: UBERON:0002149 ! superior salivatory nucleus intersection_of: BFO:0000050 NCBITaxon:10090 ! part of Mus musculus relationship: BFO:0000050 MBA:987 ! part of Pons, motor related property_value: IAO:0000028 "SSN" xsd:string property_value: skos:prefLabel "Superior salivatory nucleus ( mouse )" xsd:string [Term] id: MBA:463 name: Field CA3 synonym: "CA3" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=1#structure=463 xref: http://atlas.brain-map.org/atlas?atlas=2#structure=463 xref: http://atlas.brain-map.org/atlas?atlas=602630314#structure=463 is_a: MBA:8 ! Basic cell groups and regions is_a: UBERON:0003883 ! CA3 field of hippocampus intersection_of: UBERON:0003883 ! CA3 field of hippocampus intersection_of: BFO:0000050 NCBITaxon:10090 ! part of Mus musculus relationship: BFO:0000050 MBA:375 ! part of Ammon's horn property_value: IAO:0000028 "CA3" xsd:string property_value: skos:prefLabel "Field CA3 ( mouse )" xsd:string [Term] id: MBA:466 name: alveus synonym: "alv" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=1#structure=466 xref: http://atlas.brain-map.org/atlas?atlas=2#structure=466 xref: http://atlas.brain-map.org/atlas?atlas=602630314#structure=466 is_a: MBA:ENTITY is_a: UBERON:0007639 ! hippocampus alveus is_a: UBERON:0014532 ! white matter lamina of cerebral hemisphere intersection_of: UBERON:0007639 ! hippocampus alveus intersection_of: BFO:0000050 NCBITaxon:10090 ! part of Mus musculus relationship: BFO:0000050 MBA:1099 ! part of fornix system property_value: IAO:0000028 "alv" xsd:string property_value: skos:prefLabel "alveus ( mouse )" xsd:string [Term] id: MBA:467 name: Hypothalamic medial zone synonym: "MEZ" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=1#structure=467 xref: http://atlas.brain-map.org/atlas?atlas=2#structure=467 xref: http://atlas.brain-map.org/atlas?atlas=602630314#structure=467 is_a: MBA:ENTITY is_a: UBERON:0002272 ! medial zone of hypothalamus intersection_of: UBERON:0002272 ! medial zone of hypothalamus intersection_of: BFO:0000050 NCBITaxon:10090 ! part of Mus musculus relationship: BFO:0000050 MBA:1097 ! part of Hypothalamus property_value: IAO:0000028 "MEZ" xsd:string property_value: skos:prefLabel "Hypothalamic medial zone ( mouse )" xsd:string [Term] id: MBA:470 name: Subthalamic nucleus synonym: "STN" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=1#structure=470 xref: http://atlas.brain-map.org/atlas?atlas=2#structure=470 xref: http://atlas.brain-map.org/atlas?atlas=602630314#structure=470 is_a: MBA:ENTITY is_a: UBERON:0001906 ! subthalamic nucleus is_a: UBERON:0006331 ! brainstem nucleus is_a: UBERON:0006568 ! hypothalamic nucleus intersection_of: UBERON:0001906 ! subthalamic nucleus intersection_of: BFO:0000050 NCBITaxon:10090 ! part of Mus musculus relationship: BFO:0000050 MBA:290 ! part of Hypothalamic lateral zone property_value: IAO:0000028 "STN" xsd:string property_value: skos:prefLabel "Subthalamic nucleus ( mouse )" xsd:string [Term] id: MBA:477 name: Striatum synonym: "STR" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=1#structure=477 xref: http://atlas.brain-map.org/atlas?atlas=2#structure=477 xref: http://atlas.brain-map.org/atlas?atlas=602630314#structure=477 is_a: MBA:ENTITY is_a: UBERON:0002435 ! striatum intersection_of: UBERON:0002435 ! striatum intersection_of: BFO:0000050 NCBITaxon:10090 ! part of Mus musculus relationship: BFO:0000050 MBA:623 ! part of Cerebral nuclei property_value: IAO:0000028 "STR" xsd:string property_value: skos:prefLabel "Striatum ( mouse )" xsd:string [Term] id: MBA:481 name: Islands of Calleja synonym: "isl" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=1#structure=481 xref: http://atlas.brain-map.org/atlas?atlas=2#structure=481 xref: http://atlas.brain-map.org/atlas?atlas=602630314#structure=481 is_a: MBA:ENTITY is_a: UBERON:0001881 ! island of Calleja intersection_of: UBERON:0001881 ! island of Calleja intersection_of: BFO:0000050 NCBITaxon:10090 ! part of Mus musculus relationship: BFO:0000050 MBA:754 ! part of Olfactory tubercle property_value: IAO:0000028 "isl" xsd:string property_value: skos:prefLabel "Islands of Calleja ( mouse )" xsd:string [Term] id: MBA:484682516 name: corpus callosum, body synonym: "ccb" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=1#structure=484682516 xref: http://atlas.brain-map.org/atlas?atlas=2#structure=484682516 xref: http://atlas.brain-map.org/atlas?atlas=602630314#structure=484682516 is_a: BFO:0000004 relationship: BFO:0000050 MBA:776 ! part of corpus callosum property_value: IAO:0000028 "ccb" xsd:string property_value: skos:prefLabel "corpus callosum, body ( mouse )" xsd:string [Term] id: MBA:485 name: Striatum dorsal region synonym: "STRd" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=1#structure=485 xref: http://atlas.brain-map.org/atlas?atlas=2#structure=485 xref: http://atlas.brain-map.org/atlas?atlas=602630314#structure=485 is_a: MBA:ENTITY is_a: UBERON:0005382 ! dorsal striatum intersection_of: UBERON:0005382 ! dorsal striatum intersection_of: BFO:0000050 NCBITaxon:10090 ! part of Mus musculus relationship: BFO:0000050 MBA:477 ! part of Striatum property_value: IAO:0000028 "STRd" xsd:string property_value: skos:prefLabel "Striatum dorsal region ( mouse )" xsd:string [Term] id: MBA:486 name: Field CA3, stratum oriens synonym: "CA3so" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=1#structure=486 xref: http://atlas.brain-map.org/atlas?atlas=2#structure=486 xref: http://atlas.brain-map.org/atlas?atlas=602630314#structure=486 is_a: MBA:ENTITY is_a: UBERON:0014553 ! CA3 stratum oriens intersection_of: UBERON:0014553 ! CA3 stratum oriens intersection_of: BFO:0000050 NCBITaxon:10090 ! part of Mus musculus relationship: BFO:0000050 MBA:463 ! part of Field CA3 property_value: IAO:0000028 "CA3so" xsd:string property_value: skos:prefLabel "Field CA3, stratum oriens ( mouse )" xsd:string [Term] id: MBA:493 name: Striatum ventral region synonym: "STRv" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=1#structure=493 xref: http://atlas.brain-map.org/atlas?atlas=2#structure=493 xref: http://atlas.brain-map.org/atlas?atlas=602630314#structure=493 is_a: MBA:ENTITY is_a: UBERON:0005403 ! ventral striatum intersection_of: UBERON:0005403 ! ventral striatum intersection_of: BFO:0000050 NCBITaxon:10090 ! part of Mus musculus relationship: BFO:0000050 MBA:477 ! part of Striatum property_value: IAO:0000028 "STRv" xsd:string property_value: skos:prefLabel "Striatum ventral region ( mouse )" xsd:string [Term] id: MBA:495 name: Field CA3, pyramidal layer synonym: "CA3sp" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=1#structure=495 xref: http://atlas.brain-map.org/atlas?atlas=2#structure=495 xref: http://atlas.brain-map.org/atlas?atlas=602630314#structure=495 is_a: MBA:ENTITY is_a: UBERON:0014550 ! pyramidal layer of CA3 intersection_of: UBERON:0014550 ! pyramidal layer of CA3 intersection_of: BFO:0000050 NCBITaxon:10090 ! part of Mus musculus relationship: BFO:0000050 MBA:463 ! part of Field CA3 property_value: IAO:0000028 "CA3sp" xsd:string property_value: skos:prefLabel "Field CA3, pyramidal layer ( mouse )" xsd:string [Term] id: MBA:500 name: Somatomotor areas synonym: "MO" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=1#structure=500 xref: http://atlas.brain-map.org/atlas?atlas=2#structure=500 xref: http://atlas.brain-map.org/atlas?atlas=602630314#structure=500 is_a: MBA:8 ! Basic cell groups and regions is_a: UBERON:8440076 ! somatomotor area intersection_of: UBERON:8440076 ! somatomotor area intersection_of: BFO:0000050 NCBITaxon:10090 ! part of Mus musculus relationship: BFO:0000050 MBA:315 ! part of Isocortex property_value: IAO:0000028 "MO" xsd:string property_value: skos:prefLabel "Somatomotor areas ( mouse )" xsd:string [Term] id: MBA:502 name: Subiculum synonym: "SUB" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=1#structure=502 xref: http://atlas.brain-map.org/atlas?atlas=2#structure=502 xref: http://atlas.brain-map.org/atlas?atlas=602630314#structure=502 is_a: MBA:8 ! Basic cell groups and regions is_a: UBERON:0002191 ! subiculum intersection_of: UBERON:0002191 ! subiculum intersection_of: BFO:0000050 NCBITaxon:10090 ! part of Mus musculus relationship: BFO:0000050 MBA:822 ! part of Retrohippocampal region property_value: IAO:0000028 "SUB" xsd:string property_value: skos:prefLabel "Subiculum ( mouse )" xsd:string [Term] id: MBA:504 name: Field CA3, stratum radiatum synonym: "CA3sr" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=1#structure=504 xref: http://atlas.brain-map.org/atlas?atlas=2#structure=504 xref: http://atlas.brain-map.org/atlas?atlas=602630314#structure=504 is_a: MBA:ENTITY is_a: UBERON:0014556 ! CA3 stratum radiatum intersection_of: UBERON:0014556 ! CA3 stratum radiatum intersection_of: BFO:0000050 NCBITaxon:10090 ! part of Mus musculus relationship: BFO:0000050 MBA:463 ! part of Field CA3 property_value: IAO:0000028 "CA3sr" xsd:string property_value: skos:prefLabel "Field CA3, stratum radiatum ( mouse )" xsd:string [Term] id: MBA:507 name: Main olfactory bulb synonym: "MOB" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=1#structure=507 xref: http://atlas.brain-map.org/atlas?atlas=2#structure=507 xref: http://atlas.brain-map.org/atlas?atlas=602630314#structure=507 is_a: MBA:8 ! Basic cell groups and regions is_a: UBERON:0009951 ! main olfactory bulb intersection_of: UBERON:0009951 ! main olfactory bulb intersection_of: BFO:0000050 NCBITaxon:10090 ! part of Mus musculus relationship: BFO:0000050 MBA:698 ! part of Olfactory areas property_value: IAO:0000028 "MOB" xsd:string property_value: skos:prefLabel "Main olfactory bulb ( mouse )" xsd:string [Term] id: MBA:512 name: Cerebellum synonym: "CB" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=1#structure=512 xref: http://atlas.brain-map.org/atlas?atlas=2#structure=512 xref: http://atlas.brain-map.org/atlas?atlas=602630314#structure=512 is_a: MBA:8 ! Basic cell groups and regions is_a: UBERON:0002037 ! cerebellum intersection_of: UBERON:0002037 ! cerebellum intersection_of: BFO:0000050 NCBITaxon:10090 ! part of Mus musculus relationship: BFO:0000050 MBA:8 ! part of Basic cell groups and regions property_value: IAO:0000028 "CB" xsd:string property_value: skos:prefLabel "Cerebellum ( mouse )" xsd:string [Term] id: MBA:519 name: Cerebellar nuclei synonym: "CBN" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=1#structure=519 xref: http://atlas.brain-map.org/atlas?atlas=2#structure=519 xref: http://atlas.brain-map.org/atlas?atlas=602630314#structure=519 is_a: MBA:ENTITY is_a: UBERON:0002130 ! cerebellar nuclear complex intersection_of: UBERON:0002130 ! cerebellar nuclear complex intersection_of: BFO:0000050 NCBITaxon:10090 ! part of Mus musculus relationship: BFO:0000050 MBA:512 ! part of Cerebellum property_value: IAO:0000028 "CBN" xsd:string property_value: skos:prefLabel "Cerebellar nuclei ( mouse )" xsd:string [Term] id: MBA:528 name: Cerebellar cortex synonym: "CBX" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=1#structure=528 xref: http://atlas.brain-map.org/atlas?atlas=2#structure=528 xref: http://atlas.brain-map.org/atlas?atlas=602630314#structure=528 is_a: MBA:ENTITY is_a: UBERON:0002129 ! cerebellar cortex intersection_of: UBERON:0002129 ! cerebellar cortex intersection_of: BFO:0000050 NCBITaxon:10090 ! part of Mus musculus relationship: BFO:0000050 MBA:512 ! part of Cerebellum property_value: IAO:0000028 "CBX" xsd:string property_value: skos:prefLabel "Cerebellar cortex ( mouse )" xsd:string [Term] id: MBA:549 name: Thalamus synonym: "TH" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=1#structure=549 xref: http://atlas.brain-map.org/atlas?atlas=2#structure=549 xref: http://atlas.brain-map.org/atlas?atlas=602630314#structure=549 is_a: MBA:8 ! Basic cell groups and regions is_a: UBERON:0001897 ! dorsal plus ventral thalamus intersection_of: UBERON:0001897 ! dorsal plus ventral thalamus intersection_of: BFO:0000050 NCBITaxon:10090 ! part of Mus musculus relationship: BFO:0000050 MBA:1129 ! part of Interbrain property_value: IAO:0000028 "TH" xsd:string property_value: skos:prefLabel "Thalamus ( mouse )" xsd:string [Term] id: MBA:56 name: Nucleus accumbens synonym: "ACB" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=1#structure=56 xref: http://atlas.brain-map.org/atlas?atlas=2#structure=56 xref: http://atlas.brain-map.org/atlas?atlas=602630314#structure=56 is_a: MBA:ENTITY is_a: UBERON:0001882 ! nucleus accumbens intersection_of: UBERON:0001882 ! nucleus accumbens intersection_of: BFO:0000050 NCBITaxon:10090 ! part of Mus musculus relationship: BFO:0000050 MBA:493 ! part of Striatum ventral region property_value: IAO:0000028 "ACB" xsd:string property_value: skos:prefLabel "Nucleus accumbens ( mouse )" xsd:string [Term] id: MBA:564 name: Medial septal nucleus synonym: "MS" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=1#structure=564 xref: http://atlas.brain-map.org/atlas?atlas=2#structure=564 xref: http://atlas.brain-map.org/atlas?atlas=602630314#structure=564 is_a: MBA:ENTITY is_a: UBERON:0001877 ! medial septal nucleus intersection_of: UBERON:0001877 ! medial septal nucleus intersection_of: BFO:0000050 NCBITaxon:10090 ! part of Mus musculus relationship: BFO:0000050 MBA:904 ! part of Medial septal complex property_value: IAO:0000028 "MS" xsd:string property_value: skos:prefLabel "Medial septal nucleus ( mouse )" xsd:string [Term] id: MBA:567 name: Cerebrum synonym: "CH" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=1#structure=567 xref: http://atlas.brain-map.org/atlas?atlas=2#structure=567 xref: http://atlas.brain-map.org/atlas?atlas=602630314#structure=567 is_a: MBA:8 ! Basic cell groups and regions is_a: UBERON:0001893 ! telencephalon intersection_of: UBERON:0001893 ! telencephalon intersection_of: BFO:0000050 NCBITaxon:10090 ! part of Mus musculus relationship: BFO:0000050 MBA:8 ! part of Basic cell groups and regions property_value: IAO:0000028 "CH" xsd:string property_value: skos:prefLabel "Cerebrum ( mouse )" xsd:string [Term] id: MBA:579 name: external capsule synonym: "ec" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=1#structure=579 xref: http://atlas.brain-map.org/atlas?atlas=2#structure=579 xref: http://atlas.brain-map.org/atlas?atlas=602630314#structure=579 is_a: MBA:ENTITY is_a: UBERON:0004545 ! external capsule of telencephalon intersection_of: UBERON:0004545 ! external capsule of telencephalon intersection_of: BFO:0000050 NCBITaxon:10090 ! part of Mus musculus relationship: BFO:0000050 MBA:956 ! part of corpus callosum, anterior forceps property_value: IAO:0000028 "ec" xsd:string property_value: skos:prefLabel "external capsule ( mouse )" xsd:string [Term] id: MBA:596 name: Diagonal band nucleus synonym: "NDB" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=1#structure=596 xref: http://atlas.brain-map.org/atlas?atlas=2#structure=596 xref: http://atlas.brain-map.org/atlas?atlas=602630314#structure=596 is_a: MBA:ENTITY is_a: UBERON:0001879 ! nucleus of diagonal band intersection_of: UBERON:0001879 ! nucleus of diagonal band intersection_of: BFO:0000050 NCBITaxon:10090 ! part of Mus musculus relationship: BFO:0000050 MBA:904 ! part of Medial septal complex property_value: IAO:0000028 "NDB" xsd:string property_value: skos:prefLabel "Diagonal band nucleus ( mouse )" xsd:string [Term] id: MBA:599626923 name: Subcommissural organ synonym: "SCO" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=1#structure=599626923 xref: http://atlas.brain-map.org/atlas?atlas=2#structure=599626923 xref: http://atlas.brain-map.org/atlas?atlas=602630314#structure=599626923 is_a: MBA:8 ! Basic cell groups and regions is_a: UBERON:0002139 ! subcommissural organ intersection_of: UBERON:0002139 ! subcommissural organ intersection_of: BFO:0000050 NCBITaxon:10090 ! part of Mus musculus relationship: BFO:0000050 MBA:339 ! part of Midbrain, sensory related property_value: IAO:0000028 "SCO" xsd:string property_value: skos:prefLabel "Subcommissural organ ( mouse )" xsd:string [Term] id: MBA:603 name: fimbria synonym: "fi" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=1#structure=603 xref: http://atlas.brain-map.org/atlas?atlas=2#structure=603 xref: http://atlas.brain-map.org/atlas?atlas=602630314#structure=603 is_a: MBA:ENTITY is_a: UBERON:0002310 ! hippocampus fimbria intersection_of: UBERON:0002310 ! hippocampus fimbria intersection_of: BFO:0000050 NCBITaxon:10090 ! part of Mus musculus relationship: BFO:0000050 MBA:1099 ! part of fornix system property_value: IAO:0000028 "fi" xsd:string property_value: skos:prefLabel "fimbria ( mouse )" xsd:string [Term] id: MBA:607 name: Cochlear nuclei synonym: "CN" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=1#structure=607 xref: http://atlas.brain-map.org/atlas?atlas=2#structure=607 xref: http://atlas.brain-map.org/atlas?atlas=602630314#structure=607 is_a: MBA:ENTITY is_a: UBERON:0002610 ! cochlear nuclear complex intersection_of: UBERON:0002610 ! cochlear nuclear complex intersection_of: BFO:0000050 NCBITaxon:10090 ! part of Mus musculus relationship: BFO:0000050 MBA:386 ! part of Medulla, sensory related property_value: IAO:0000028 "CN" xsd:string property_value: skos:prefLabel "Cochlear nuclei ( mouse )" xsd:string [Term] id: MBA:619 name: Nucleus of the lateral olfactory tract synonym: "NLOT" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=1#structure=619 xref: http://atlas.brain-map.org/atlas?atlas=2#structure=619 xref: http://atlas.brain-map.org/atlas?atlas=602630314#structure=619 is_a: MBA:ENTITY is_a: UBERON:0002893 ! nucleus of lateral olfactory tract intersection_of: UBERON:0002893 ! nucleus of lateral olfactory tract intersection_of: BFO:0000050 NCBITaxon:10090 ! part of Mus musculus relationship: BFO:0000050 MBA:698 ! part of Olfactory areas property_value: IAO:0000028 "NLOT" xsd:string property_value: skos:prefLabel "Nucleus of the lateral olfactory tract ( mouse )" xsd:string [Term] id: MBA:623 name: Cerebral nuclei synonym: "CNU" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=1#structure=623 xref: http://atlas.brain-map.org/atlas?atlas=2#structure=623 xref: http://atlas.brain-map.org/atlas?atlas=602630314#structure=623 is_a: MBA:ENTITY is_a: UBERON:8440012 ! cerebral nuclei intersection_of: UBERON:8440012 ! cerebral nuclei intersection_of: BFO:0000050 NCBITaxon:10090 ! part of Mus musculus relationship: BFO:0000050 MBA:567 ! part of Cerebrum property_value: IAO:0000028 "CNU" xsd:string property_value: skos:prefLabel "Cerebral nuclei ( mouse )" xsd:string [Term] id: MBA:632 name: Dentate gyrus, granule cell layer synonym: "DG-sg" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=1#structure=632 xref: http://atlas.brain-map.org/atlas?atlas=2#structure=632 xref: http://atlas.brain-map.org/atlas?atlas=602630314#structure=632 is_a: MBA:ENTITY is_a: UBERON:0005381 ! dentate gyrus granule cell layer intersection_of: UBERON:0005381 ! dentate gyrus granule cell layer intersection_of: BFO:0000050 NCBITaxon:10090 ! part of Mus musculus relationship: BFO:0000050 MBA:726 ! part of Dentate gyrus property_value: IAO:0000028 "DG-sg" xsd:string property_value: skos:prefLabel "Dentate gyrus, granule cell layer ( mouse )" xsd:string [Term] id: MBA:637 name: Ventral group of the dorsal thalamus synonym: "VENT" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=1#structure=637 xref: http://atlas.brain-map.org/atlas?atlas=2#structure=637 xref: http://atlas.brain-map.org/atlas?atlas=602630314#structure=637 is_a: MBA:ENTITY is_a: UBERON:0002776 ! ventral nuclear group is_a: UBERON:0006331 ! brainstem nucleus intersection_of: UBERON:0002776 ! ventral nuclear group intersection_of: BFO:0000050 NCBITaxon:10090 ! part of Mus musculus relationship: BFO:0000050 MBA:864 ! part of Thalamus, sensory-motor cortex related property_value: IAO:0000028 "VENT" xsd:string property_value: skos:prefLabel "Ventral group of the dorsal thalamus ( mouse )" xsd:string [Term] id: MBA:644 name: Somatomotor areas, Layer 6a synonym: "MO6a" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=1#structure=644 xref: http://atlas.brain-map.org/atlas?atlas=2#structure=644 xref: http://atlas.brain-map.org/atlas?atlas=602630314#structure=644 is_a: MBA:ENTITY is_a: UBERON:0005395 ! cortical layer VI intersection_of: BFO:0000050 NCBITaxon:10090 {all_some="true"} ! part of Mus musculus intersection_of: BFO:0000050 UBERON:8440076 ! part of somatomotor area relationship: BFO:0000050 MBA:500 ! part of Somatomotor areas property_value: IAO:0000028 "MO6a" xsd:string property_value: skos:prefLabel "Somatomotor areas, Layer 6a ( mouse )" xsd:string [Term] id: MBA:645 name: Vermal regions synonym: "VERM" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=1#structure=645 xref: http://atlas.brain-map.org/atlas?atlas=2#structure=645 xref: http://atlas.brain-map.org/atlas?atlas=602630314#structure=645 is_a: MBA:8 ! Basic cell groups and regions is_a: UBERON:0004720 ! cerebellar vermis intersection_of: UBERON:0004720 ! cerebellar vermis intersection_of: BFO:0000050 NCBITaxon:10090 ! part of Mus musculus relationship: BFO:0000050 MBA:528 ! part of Cerebellar cortex property_value: IAO:0000028 "VERM" xsd:string property_value: skos:prefLabel "Vermal regions ( mouse )" xsd:string [Term] id: MBA:665 name: lateral olfactory tract, body synonym: "lot" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=1#structure=665 xref: http://atlas.brain-map.org/atlas?atlas=2#structure=665 xref: http://atlas.brain-map.org/atlas?atlas=602630314#structure=665 is_a: MBA:1009 ! fiber tracts is_a: UBERON:0001888 ! lateral olfactory stria intersection_of: UBERON:0001888 ! lateral olfactory stria intersection_of: BFO:0000050 NCBITaxon:10090 ! part of Mus musculus relationship: BFO:0000050 MBA:21 ! part of lateral olfactory tract, general property_value: IAO:0000028 "lot" xsd:string property_value: skos:prefLabel "lateral olfactory tract, body ( mouse )" xsd:string [Term] id: MBA:672 name: Caudoputamen synonym: "CP" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=1#structure=672 xref: http://atlas.brain-map.org/atlas?atlas=2#structure=672 xref: http://atlas.brain-map.org/atlas?atlas=602630314#structure=672 is_a: MBA:ENTITY is_a: UBERON:0005383 ! caudate-putamen intersection_of: UBERON:0005383 ! caudate-putamen intersection_of: BFO:0000050 NCBITaxon:10090 ! part of Mus musculus relationship: BFO:0000050 MBA:485 ! part of Striatum dorsal region property_value: IAO:0000028 "CP" xsd:string property_value: skos:prefLabel "Caudoputamen ( mouse )" xsd:string [Term] id: MBA:688 name: Cerebral cortex synonym: "CTX" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=1#structure=688 xref: http://atlas.brain-map.org/atlas?atlas=2#structure=688 xref: http://atlas.brain-map.org/atlas?atlas=602630314#structure=688 is_a: MBA:ENTITY is_a: UBERON:0000956 ! cerebral cortex intersection_of: UBERON:0000956 ! cerebral cortex intersection_of: BFO:0000050 NCBITaxon:10090 ! part of Mus musculus relationship: BFO:0000050 MBA:567 ! part of Cerebrum property_value: IAO:0000028 "CTX" xsd:string property_value: skos:prefLabel "Cerebral cortex ( mouse )" xsd:string [Term] id: MBA:695 name: Cortical plate synonym: "CTXpl" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=1#structure=695 xref: http://atlas.brain-map.org/atlas?atlas=2#structure=695 xref: http://atlas.brain-map.org/atlas?atlas=602630314#structure=695 is_a: MBA:ENTITY is_a: UBERON:0005343 ! cortical plate intersection_of: UBERON:0005343 ! cortical plate intersection_of: BFO:0000050 NCBITaxon:10090 ! part of Mus musculus relationship: BFO:0000050 MBA:688 ! part of Cerebral cortex property_value: IAO:0000028 "CTXpl" xsd:string property_value: skos:prefLabel "Cortical plate ( mouse )" xsd:string [Term] id: MBA:698 name: Olfactory areas synonym: "OLF" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=1#structure=698 xref: http://atlas.brain-map.org/atlas?atlas=2#structure=698 xref: http://atlas.brain-map.org/atlas?atlas=602630314#structure=698 is_a: MBA:8 ! Basic cell groups and regions is_a: UBERON:0002894 ! olfactory cortex intersection_of: UBERON:0002894 ! olfactory cortex intersection_of: BFO:0000050 NCBITaxon:10090 ! part of Mus musculus relationship: BFO:0000050 MBA:695 ! part of Cortical plate property_value: IAO:0000028 "OLF" xsd:string property_value: skos:prefLabel "Olfactory areas ( mouse )" xsd:string [Term] id: MBA:701 name: Vestibular nuclei synonym: "VNC" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=1#structure=701 xref: http://atlas.brain-map.org/atlas?atlas=2#structure=701 xref: http://atlas.brain-map.org/atlas?atlas=602630314#structure=701 is_a: MBA:ENTITY is_a: UBERON:0002673 ! vestibular nuclear complex intersection_of: UBERON:0002673 ! vestibular nuclear complex intersection_of: BFO:0000050 NCBITaxon:10090 ! part of Mus musculus relationship: BFO:0000050 MBA:370 ! part of Medulla, motor related property_value: IAO:0000028 "VNC" xsd:string property_value: skos:prefLabel "Vestibular nuclei ( mouse )" xsd:string [Term] id: MBA:703 name: Cortical subplate synonym: "CTXsp" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=1#structure=703 xref: http://atlas.brain-map.org/atlas?atlas=2#structure=703 xref: http://atlas.brain-map.org/atlas?atlas=602630314#structure=703 is_a: MBA:ENTITY is_a: UBERON:0004035 ! cortical subplate intersection_of: UBERON:0004035 ! cortical subplate intersection_of: BFO:0000050 NCBITaxon:10090 ! part of Mus musculus relationship: BFO:0000050 MBA:688 ! part of Cerebral cortex property_value: IAO:0000028 "CTXsp" xsd:string property_value: skos:prefLabel "Cortical subplate ( mouse )" xsd:string [Term] id: MBA:709 name: Ventral posterior complex of the thalamus synonym: "VP" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=1#structure=709 xref: http://atlas.brain-map.org/atlas?atlas=2#structure=709 xref: http://atlas.brain-map.org/atlas?atlas=602630314#structure=709 is_a: MBA:ENTITY is_a: UBERON:0002596 ! ventral posterior nucleus of thalamus is_a: UBERON:0006331 ! brainstem nucleus intersection_of: UBERON:0002596 ! ventral posterior nucleus of thalamus intersection_of: BFO:0000050 NCBITaxon:10090 ! part of Mus musculus relationship: BFO:0000050 MBA:637 ! part of Ventral group of the dorsal thalamus property_value: IAO:0000028 "VP" xsd:string property_value: skos:prefLabel "Ventral posterior complex of the thalamus ( mouse )" xsd:string [Term] id: MBA:717 name: accessory spinal nerve synonym: "XIn" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=1#structure=717 xref: http://atlas.brain-map.org/atlas?atlas=2#structure=717 xref: http://atlas.brain-map.org/atlas?atlas=602630314#structure=717 is_a: MBA:1009 ! fiber tracts is_a: UBERON:0014615 ! accessory nerve root intersection_of: UBERON:0014615 ! accessory nerve root intersection_of: BFO:0000050 NCBITaxon:10090 ! part of Mus musculus relationship: BFO:0000050 MBA:967 ! part of cranial nerves property_value: IAO:0000028 "XIn" xsd:string property_value: skos:prefLabel "accessory spinal nerve ( mouse )" xsd:string [Term] id: MBA:726 name: Dentate gyrus synonym: "DG" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=1#structure=726 xref: http://atlas.brain-map.org/atlas?atlas=2#structure=726 xref: http://atlas.brain-map.org/atlas?atlas=602630314#structure=726 is_a: MBA:8 ! Basic cell groups and regions is_a: UBERON:0001885 ! dentate gyrus of hippocampal formation intersection_of: UBERON:0001885 ! dentate gyrus of hippocampal formation intersection_of: BFO:0000050 NCBITaxon:10090 ! part of Mus musculus relationship: BFO:0000050 MBA:1080 ! part of Hippocampal region property_value: IAO:0000028 "DG" xsd:string property_value: skos:prefLabel "Dentate gyrus ( mouse )" xsd:string [Term] id: MBA:728 name: arbor vitae synonym: "arb" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=1#structure=728 xref: http://atlas.brain-map.org/atlas?atlas=2#structure=728 xref: http://atlas.brain-map.org/atlas?atlas=602630314#structure=728 is_a: BFO:0000004 relationship: BFO:0000050 MBA:960 ! part of cerebellum related fiber tracts property_value: IAO:0000028 "arb" xsd:string property_value: skos:prefLabel "arbor vitae ( mouse )" xsd:string [Term] id: MBA:73 name: ventricular systems synonym: "VS" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=1#structure=73 xref: http://atlas.brain-map.org/atlas?atlas=2#structure=73 xref: http://atlas.brain-map.org/atlas?atlas=602630314#structure=73 is_a: MBA:ENTITY is_a: UBERON:0005281 ! ventricular system of central nervous system intersection_of: UBERON:0005281 ! ventricular system of central nervous system intersection_of: BFO:0000050 NCBITaxon:10090 ! part of Mus musculus relationship: BFO:0000050 MBA:997 ! part of brain property_value: IAO:0000028 "VS" xsd:string property_value: skos:prefLabel "ventricular systems ( mouse )" xsd:string [Term] id: MBA:733 name: Ventral posteromedial nucleus of the thalamus synonym: "VPM" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=1#structure=733 xref: http://atlas.brain-map.org/atlas?atlas=2#structure=733 xref: http://atlas.brain-map.org/atlas?atlas=602630314#structure=733 is_a: MBA:ENTITY is_a: UBERON:0002945 ! ventral posteromedial nucleus of thalamus is_a: UBERON:0006331 ! brainstem nucleus intersection_of: UBERON:0002945 ! ventral posteromedial nucleus of thalamus intersection_of: BFO:0000050 NCBITaxon:10090 ! part of Mus musculus relationship: BFO:0000050 MBA:709 ! part of Ventral posterior complex of the thalamus property_value: IAO:0000028 "VPM" xsd:string property_value: skos:prefLabel "Ventral posteromedial nucleus of the thalamus ( mouse )" xsd:string [Term] id: MBA:744 name: cerebellar commissure synonym: "cbc" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=1#structure=744 xref: http://atlas.brain-map.org/atlas?atlas=2#structure=744 xref: http://atlas.brain-map.org/atlas?atlas=602630314#structure=744 is_a: MBA:1009 ! fiber tracts is_a: UBERON:0005970 ! brain commissure is_a: UBERON:0006847 ! cerebellar commissure intersection_of: UBERON:0006847 ! cerebellar commissure intersection_of: BFO:0000050 NCBITaxon:10090 ! part of Mus musculus relationship: BFO:0000050 MBA:960 ! part of cerebellum related fiber tracts property_value: IAO:0000028 "cbc" xsd:string property_value: skos:prefLabel "cerebellar commissure ( mouse )" xsd:string [Term] id: MBA:749 name: Ventral tegmental area synonym: "VTA" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=1#structure=749 xref: http://atlas.brain-map.org/atlas?atlas=2#structure=749 xref: http://atlas.brain-map.org/atlas?atlas=602630314#structure=749 is_a: MBA:8 ! Basic cell groups and regions is_a: UBERON:0002691 ! ventral tegmental area intersection_of: UBERON:0002691 ! ventral tegmental area intersection_of: BFO:0000050 NCBITaxon:10090 ! part of Mus musculus relationship: BFO:0000050 MBA:323 ! part of Midbrain, motor related property_value: IAO:0000028 "VTA" xsd:string property_value: skos:prefLabel "Ventral tegmental area ( mouse )" xsd:string [Term] id: MBA:752 name: cerebellar peduncles synonym: "cbp" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=1#structure=752 xref: http://atlas.brain-map.org/atlas?atlas=2#structure=752 xref: http://atlas.brain-map.org/atlas?atlas=602630314#structure=752 is_a: MBA:ENTITY is_a: UBERON:0007416 ! cerebellar peduncle intersection_of: UBERON:0007416 ! cerebellar peduncle intersection_of: BFO:0000050 NCBITaxon:10090 ! part of Mus musculus relationship: BFO:0000050 MBA:960 ! part of cerebellum related fiber tracts property_value: IAO:0000028 "cbp" xsd:string property_value: skos:prefLabel "cerebellar peduncles ( mouse )" xsd:string [Term] id: MBA:754 name: Olfactory tubercle synonym: "OT" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=1#structure=754 xref: http://atlas.brain-map.org/atlas?atlas=2#structure=754 xref: http://atlas.brain-map.org/atlas?atlas=602630314#structure=754 is_a: MBA:ENTITY is_a: UBERON:0001883 ! olfactory tubercle intersection_of: UBERON:0001883 ! olfactory tubercle intersection_of: BFO:0000050 NCBITaxon:10090 ! part of Mus musculus relationship: BFO:0000050 MBA:493 ! part of Striatum ventral region property_value: IAO:0000028 "OT" xsd:string property_value: skos:prefLabel "Olfactory tubercle ( mouse )" xsd:string [Term] id: MBA:763 name: Vascular organ of the lamina terminalis synonym: "OV" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=1#structure=763 xref: http://atlas.brain-map.org/atlas?atlas=2#structure=763 xref: http://atlas.brain-map.org/atlas?atlas=602630314#structure=763 is_a: MBA:8 ! Basic cell groups and regions is_a: UBERON:0002689 ! supraoptic crest intersection_of: UBERON:0002689 ! supraoptic crest intersection_of: BFO:0000050 NCBITaxon:10090 ! part of Mus musculus relationship: BFO:0000050 MBA:141 ! part of Periventricular region property_value: IAO:0000028 "OV" xsd:string property_value: skos:prefLabel "Vascular organ of the lamina terminalis ( mouse )" xsd:string [Term] id: MBA:768 name: cerebrum related synonym: "mfbc" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=1#structure=768 xref: http://atlas.brain-map.org/atlas?atlas=2#structure=768 xref: http://atlas.brain-map.org/atlas?atlas=602630314#structure=768 is_a: BFO:0000004 relationship: BFO:0000050 MBA:991 ! part of medial forebrain bundle system property_value: IAO:0000028 "mfbc" xsd:string property_value: skos:prefLabel "cerebrum related ( mouse )" xsd:string [Term] id: MBA:771 name: Pons synonym: "P" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=1#structure=771 xref: http://atlas.brain-map.org/atlas?atlas=2#structure=771 xref: http://atlas.brain-map.org/atlas?atlas=602630314#structure=771 is_a: MBA:8 ! Basic cell groups and regions is_a: UBERON:0000988 ! pons intersection_of: UBERON:0000988 ! pons intersection_of: BFO:0000050 NCBITaxon:10090 ! part of Mus musculus relationship: BFO:0000050 MBA:1065 ! part of Hindbrain property_value: IAO:0000028 "P" xsd:string property_value: skos:prefLabel "Pons ( mouse )" xsd:string [Term] id: MBA:773 name: Hypoglossal nucleus synonym: "XII" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=1#structure=773 xref: http://atlas.brain-map.org/atlas?atlas=2#structure=773 xref: http://atlas.brain-map.org/atlas?atlas=602630314#structure=773 is_a: MBA:ENTITY is_a: UBERON:0002871 ! hypoglossal nucleus intersection_of: UBERON:0002871 ! hypoglossal nucleus intersection_of: BFO:0000050 NCBITaxon:10090 ! part of Mus musculus relationship: BFO:0000050 MBA:370 ! part of Medulla, motor related property_value: IAO:0000028 "XII" xsd:string property_value: skos:prefLabel "Hypoglossal nucleus ( mouse )" xsd:string [Term] id: MBA:776 name: corpus callosum synonym: "cc" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=1#structure=776 xref: http://atlas.brain-map.org/atlas?atlas=2#structure=776 xref: http://atlas.brain-map.org/atlas?atlas=602630314#structure=776 is_a: MBA:1009 ! fiber tracts is_a: UBERON:0002336 ! corpus callosum intersection_of: UBERON:0002336 ! corpus callosum intersection_of: BFO:0000050 NCBITaxon:10090 ! part of Mus musculus relationship: BFO:0000050 MBA:983 ! part of lateral forebrain bundle system property_value: IAO:0000028 "cc" xsd:string property_value: skos:prefLabel "corpus callosum ( mouse )" xsd:string [Term] id: MBA:78 name: middle cerebellar peduncle synonym: "mcp" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=1#structure=78 xref: http://atlas.brain-map.org/atlas?atlas=2#structure=78 xref: http://atlas.brain-map.org/atlas?atlas=602630314#structure=78 is_a: MBA:752 ! cerebellar peduncles is_a: UBERON:0002152 ! middle cerebellar peduncle intersection_of: UBERON:0002152 ! middle cerebellar peduncle intersection_of: BFO:0000050 NCBITaxon:10090 ! part of Mus musculus relationship: BFO:0000050 MBA:752 ! part of cerebellar peduncles property_value: IAO:0000028 "mcp" xsd:string property_value: skos:prefLabel "middle cerebellar peduncle ( mouse )" xsd:string [Term] id: MBA:784 name: corticospinal tract synonym: "cst" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=1#structure=784 xref: http://atlas.brain-map.org/atlas?atlas=2#structure=784 xref: http://atlas.brain-map.org/atlas?atlas=602630314#structure=784 is_a: MBA:1009 ! fiber tracts is_a: UBERON:0002707 ! corticospinal tract is_a: UBERON:0007702 ! tract of brain intersection_of: UBERON:0002707 ! corticospinal tract intersection_of: BFO:0000050 NCBITaxon:10090 ! part of Mus musculus relationship: BFO:0000050 MBA:983 ! part of lateral forebrain bundle system property_value: IAO:0000028 "cst" xsd:string property_value: skos:prefLabel "corticospinal tract ( mouse )" xsd:string [Term] id: MBA:796 name: Dopaminergic A13 group synonym: "A13" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=1#structure=796 xref: http://atlas.brain-map.org/atlas?atlas=2#structure=796 xref: http://atlas.brain-map.org/atlas?atlas=602630314#structure=796 is_a: MBA:8 ! Basic cell groups and regions is_a: UBERON:0036007 ! A13 dopaminergic cell group intersection_of: UBERON:0036007 ! A13 dopaminergic cell group intersection_of: BFO:0000050 NCBITaxon:10090 ! part of Mus musculus relationship: BFO:0000050 MBA:797 ! part of Zona incerta property_value: IAO:0000028 "A13" xsd:string property_value: skos:prefLabel "Dopaminergic A13 group ( mouse )" xsd:string [Term] id: MBA:797 name: Zona incerta synonym: "ZI" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=1#structure=797 xref: http://atlas.brain-map.org/atlas?atlas=2#structure=797 xref: http://atlas.brain-map.org/atlas?atlas=602630314#structure=797 is_a: MBA:ENTITY is_a: UBERON:0001907 ! zona incerta is_a: UBERON:0006331 ! brainstem nucleus is_a: UBERON:0006568 ! hypothalamic nucleus intersection_of: UBERON:0001907 ! zona incerta intersection_of: BFO:0000050 NCBITaxon:10090 ! part of Mus musculus relationship: BFO:0000050 MBA:290 ! part of Hypothalamic lateral zone property_value: IAO:0000028 "ZI" xsd:string property_value: skos:prefLabel "Zona incerta ( mouse )" xsd:string [Term] id: MBA:798 name: facial nerve synonym: "VIIn" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=1#structure=798 xref: http://atlas.brain-map.org/atlas?atlas=2#structure=798 xref: http://atlas.brain-map.org/atlas?atlas=602630314#structure=798 is_a: MBA:967 ! cranial nerves is_a: UBERON:0004674 ! facial nerve root intersection_of: UBERON:0004674 ! facial nerve root intersection_of: BFO:0000050 NCBITaxon:10090 ! part of Mus musculus relationship: BFO:0000050 MBA:967 ! part of cranial nerves property_value: IAO:0000028 "VIIn" xsd:string property_value: skos:prefLabel "facial nerve ( mouse )" xsd:string [Term] id: MBA:8 name: Basic cell groups and regions synonym: "grey" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=1#structure=8 xref: http://atlas.brain-map.org/atlas?atlas=2#structure=8 xref: http://atlas.brain-map.org/atlas?atlas=602630314#structure=8 is_a: MBA:ENTITY is_a: UBERON:0002616 ! regional part of brain intersection_of: UBERON:0002616 ! regional part of brain intersection_of: BFO:0000050 NCBITaxon:10090 ! part of Mus musculus relationship: BFO:0000050 MBA:997 ! part of brain property_value: IAO:0000028 "grey" xsd:string property_value: skos:prefLabel "Basic cell groups and regions ( mouse )" xsd:string [Term] id: MBA:803 name: Pallidum synonym: "PAL" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=1#structure=803 xref: http://atlas.brain-map.org/atlas?atlas=2#structure=803 xref: http://atlas.brain-map.org/atlas?atlas=602630314#structure=803 is_a: MBA:ENTITY is_a: UBERON:0006514 ! pallidum is_a: UBERON:0011300 ! gray matter of telencephalon intersection_of: UBERON:0006514 ! pallidum intersection_of: BFO:0000050 NCBITaxon:10090 ! part of Mus musculus relationship: BFO:0000050 MBA:623 ! part of Cerebral nuclei property_value: IAO:0000028 "PAL" xsd:string property_value: skos:prefLabel "Pallidum ( mouse )" xsd:string [Term] id: MBA:808 name: glossopharyngeal nerve synonym: "IXn" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=1#structure=808 xref: http://atlas.brain-map.org/atlas?atlas=2#structure=808 xref: http://atlas.brain-map.org/atlas?atlas=602630314#structure=808 is_a: MBA:967 ! cranial nerves is_a: UBERON:0019310 ! glossopharyngeal nerve root intersection_of: UBERON:0019310 ! glossopharyngeal nerve root intersection_of: BFO:0000050 NCBITaxon:10090 ! part of Mus musculus relationship: BFO:0000050 MBA:967 ! part of cranial nerves property_value: IAO:0000028 "IXn" xsd:string property_value: skos:prefLabel "glossopharyngeal nerve ( mouse )" xsd:string [Term] id: MBA:81 name: lateral ventricle synonym: "VL" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=1#structure=81 xref: http://atlas.brain-map.org/atlas?atlas=2#structure=81 xref: http://atlas.brain-map.org/atlas?atlas=602630314#structure=81 is_a: MBA:ENTITY is_a: UBERON:0002285 ! telencephalic ventricle intersection_of: UBERON:0002285 ! telencephalic ventricle intersection_of: BFO:0000050 NCBITaxon:10090 ! part of Mus musculus relationship: BFO:0000050 MBA:73 ! part of ventricular systems property_value: IAO:0000028 "VL" xsd:string property_value: skos:prefLabel "lateral ventricle ( mouse )" xsd:string [Term] id: MBA:813 name: hypoglossal nerve synonym: "XIIn" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=1#structure=813 xref: http://atlas.brain-map.org/atlas?atlas=2#structure=813 xref: http://atlas.brain-map.org/atlas?atlas=602630314#structure=813 is_a: MBA:967 ! cranial nerves is_a: UBERON:0004675 ! hypoglossal nerve root intersection_of: UBERON:0004675 ! hypoglossal nerve root intersection_of: BFO:0000050 NCBITaxon:10090 ! part of Mus musculus relationship: BFO:0000050 MBA:967 ! part of cranial nerves property_value: IAO:0000028 "XIIn" xsd:string property_value: skos:prefLabel "hypoglossal nerve ( mouse )" xsd:string [Term] id: MBA:818 name: Pallidum, dorsal region synonym: "PALd" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=1#structure=818 xref: http://atlas.brain-map.org/atlas?atlas=2#structure=818 xref: http://atlas.brain-map.org/atlas?atlas=602630314#structure=818 is_a: MBA:803 ! Pallidum is_a: UBERON:0006516 ! dorsal pallidum intersection_of: UBERON:0006516 ! dorsal pallidum intersection_of: BFO:0000050 NCBITaxon:10090 ! part of Mus musculus relationship: BFO:0000050 MBA:803 ! part of Pallidum property_value: IAO:0000028 "PALd" xsd:string property_value: skos:prefLabel "Pallidum, dorsal region ( mouse )" xsd:string [Term] id: MBA:822 name: Retrohippocampal region synonym: "RHP" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=1#structure=822 xref: http://atlas.brain-map.org/atlas?atlas=2#structure=822 xref: http://atlas.brain-map.org/atlas?atlas=602630314#structure=822 is_a: MBA:8 ! Basic cell groups and regions is_a: UBERON:0022230 ! retrohippocampal region intersection_of: UBERON:0022230 ! retrohippocampal region intersection_of: BFO:0000050 NCBITaxon:10090 ! part of Mus musculus relationship: BFO:0000050 MBA:1089 ! part of Hippocampal formation property_value: IAO:0000028 "RHP" xsd:string property_value: skos:prefLabel "Retrohippocampal region ( mouse )" xsd:string [Term] id: MBA:826 name: Pallidum, medial region synonym: "PALm" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=1#structure=826 xref: http://atlas.brain-map.org/atlas?atlas=2#structure=826 xref: http://atlas.brain-map.org/atlas?atlas=602630314#structure=826 is_a: BFO:0000004 relationship: BFO:0000050 MBA:803 ! part of Pallidum property_value: IAO:0000028 "PALm" xsd:string property_value: skos:prefLabel "Pallidum, medial region ( mouse )" xsd:string [Term] id: MBA:832 name: oculomotor nerve synonym: "IIIn" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=1#structure=832 xref: http://atlas.brain-map.org/atlas?atlas=2#structure=832 xref: http://atlas.brain-map.org/atlas?atlas=602630314#structure=832 is_a: MBA:967 ! cranial nerves is_a: UBERON:0002668 ! oculomotor nerve root intersection_of: UBERON:0002668 ! oculomotor nerve root intersection_of: BFO:0000050 NCBITaxon:10090 ! part of Mus musculus relationship: BFO:0000050 MBA:967 ! part of cranial nerves property_value: IAO:0000028 "IIIn" xsd:string property_value: skos:prefLabel "oculomotor nerve ( mouse )" xsd:string [Term] id: MBA:840 name: olfactory nerve synonym: "In" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=1#structure=840 xref: http://atlas.brain-map.org/atlas?atlas=2#structure=840 xref: http://atlas.brain-map.org/atlas?atlas=602630314#structure=840 is_a: MBA:967 ! cranial nerves is_a: UBERON:0019311 ! root of olfactory nerve intersection_of: UBERON:0019311 ! root of olfactory nerve intersection_of: BFO:0000050 NCBITaxon:10090 ! part of Mus musculus relationship: BFO:0000050 MBA:967 ! part of cranial nerves property_value: IAO:0000028 "In" xsd:string property_value: skos:prefLabel "olfactory nerve ( mouse )" xsd:string [Term] id: MBA:848 name: optic nerve synonym: "IIn" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=1#structure=848 xref: http://atlas.brain-map.org/atlas?atlas=2#structure=848 xref: http://atlas.brain-map.org/atlas?atlas=602630314#structure=848 is_a: MBA:1009 ! fiber tracts is_a: UBERON:0000941 ! cranial nerve II intersection_of: UBERON:0000941 ! cranial nerve II intersection_of: BFO:0000050 NCBITaxon:10090 ! part of Mus musculus relationship: BFO:0000050 MBA:967 ! part of cranial nerves property_value: IAO:0000028 "IIn" xsd:string property_value: skos:prefLabel "optic nerve ( mouse )" xsd:string [Term] id: MBA:856 name: Thalamus, polymodal association cortex related synonym: "DORpm" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=1#structure=856 xref: http://atlas.brain-map.org/atlas?atlas=2#structure=856 xref: http://atlas.brain-map.org/atlas?atlas=602630314#structure=856 is_a: BFO:0000004 relationship: BFO:0000050 MBA:549 ! part of Thalamus property_value: IAO:0000028 "DORpm" xsd:string property_value: skos:prefLabel "Thalamus, polymodal association cortex related ( mouse )" xsd:string [Term] id: MBA:863 name: rubrospinal tract synonym: "rust" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=1#structure=863 xref: http://atlas.brain-map.org/atlas?atlas=2#structure=863 xref: http://atlas.brain-map.org/atlas?atlas=602630314#structure=863 is_a: MBA:1009 ! fiber tracts is_a: UBERON:0002714 ! rubrospinal tract intersection_of: UBERON:0002714 ! rubrospinal tract intersection_of: BFO:0000050 NCBITaxon:10090 ! part of Mus musculus relationship: BFO:0000050 MBA:1000 ! part of extrapyramidal fiber systems property_value: IAO:0000028 "rust" xsd:string property_value: skos:prefLabel "rubrospinal tract ( mouse )" xsd:string [Term] id: MBA:864 name: Thalamus, sensory-motor cortex related synonym: "DORsm" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=1#structure=864 xref: http://atlas.brain-map.org/atlas?atlas=2#structure=864 xref: http://atlas.brain-map.org/atlas?atlas=602630314#structure=864 is_a: BFO:0000004 relationship: BFO:0000050 MBA:549 ! part of Thalamus property_value: IAO:0000028 "DORsm" xsd:string property_value: skos:prefLabel "Thalamus, sensory-motor cortex related ( mouse )" xsd:string [Term] id: MBA:896 name: thalamus related synonym: "lfbst" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=1#structure=896 xref: http://atlas.brain-map.org/atlas?atlas=2#structure=896 xref: http://atlas.brain-map.org/atlas?atlas=602630314#structure=896 is_a: BFO:0000004 relationship: BFO:0000050 MBA:983 ! part of lateral forebrain bundle system property_value: IAO:0000028 "lfbst" xsd:string property_value: skos:prefLabel "thalamus related ( mouse )" xsd:string [Term] id: MBA:901 name: trigeminal nerve synonym: "Vn" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=1#structure=901 xref: http://atlas.brain-map.org/atlas?atlas=2#structure=901 xref: http://atlas.brain-map.org/atlas?atlas=602630314#structure=901 is_a: MBA:967 ! cranial nerves is_a: UBERON:0004673 ! trigeminal nerve root intersection_of: UBERON:0004673 ! trigeminal nerve root intersection_of: BFO:0000050 NCBITaxon:10090 ! part of Mus musculus relationship: BFO:0000050 MBA:967 ! part of cranial nerves property_value: IAO:0000028 "Vn" xsd:string property_value: skos:prefLabel "trigeminal nerve ( mouse )" xsd:string [Term] id: MBA:904 name: Medial septal complex synonym: "MSC" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=1#structure=904 xref: http://atlas.brain-map.org/atlas?atlas=2#structure=904 xref: http://atlas.brain-map.org/atlas?atlas=602630314#structure=904 is_a: MBA:ENTITY is_a: UBERON:0007629 ! medial septal complex intersection_of: UBERON:0007629 ! medial septal complex intersection_of: BFO:0000050 NCBITaxon:10090 ! part of Mus musculus relationship: BFO:0000050 MBA:826 ! part of Pallidum, medial region property_value: IAO:0000028 "MSC" xsd:string property_value: skos:prefLabel "Medial septal complex ( mouse )" xsd:string [Term] id: MBA:91 name: Interposed nucleus synonym: "IP" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=1#structure=91 xref: http://atlas.brain-map.org/atlas?atlas=2#structure=91 xref: http://atlas.brain-map.org/atlas?atlas=602630314#structure=91 is_a: MBA:ENTITY is_a: UBERON:0004073 ! cerebellum interpositus nucleus intersection_of: UBERON:0004073 ! cerebellum interpositus nucleus intersection_of: BFO:0000050 NCBITaxon:10090 ! part of Mus musculus relationship: BFO:0000050 MBA:519 ! part of Cerebellar nuclei property_value: IAO:0000028 "IP" xsd:string property_value: skos:prefLabel "Interposed nucleus ( mouse )" xsd:string [Term] id: MBA:917 name: vagus nerve synonym: "Xn" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=1#structure=917 xref: http://atlas.brain-map.org/atlas?atlas=2#structure=917 xref: http://atlas.brain-map.org/atlas?atlas=602630314#structure=917 is_a: MBA:967 ! cranial nerves is_a: UBERON:0011213 ! root of vagus nerve intersection_of: UBERON:0011213 ! root of vagus nerve intersection_of: BFO:0000050 NCBITaxon:10090 ! part of Mus musculus relationship: BFO:0000050 MBA:967 ! part of cranial nerves property_value: IAO:0000028 "Xn" xsd:string property_value: skos:prefLabel "vagus nerve ( mouse )" xsd:string [Term] id: MBA:931 name: Pontine gray synonym: "PG" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=1#structure=931 xref: http://atlas.brain-map.org/atlas?atlas=2#structure=931 xref: http://atlas.brain-map.org/atlas?atlas=602630314#structure=931 is_a: MBA:ENTITY is_a: UBERON:0002151 ! pontine nuclear group intersection_of: UBERON:0002151 ! pontine nuclear group intersection_of: BFO:0000050 NCBITaxon:10090 ! part of Mus musculus relationship: BFO:0000050 MBA:987 ! part of Pons, motor related property_value: IAO:0000028 "PG" xsd:string property_value: skos:prefLabel "Pontine gray ( mouse )" xsd:string [Term] id: MBA:933 name: vestibulocochlear nerve synonym: "VIIIn" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=1#structure=933 xref: http://atlas.brain-map.org/atlas?atlas=2#structure=933 xref: http://atlas.brain-map.org/atlas?atlas=602630314#structure=933 is_a: MBA:967 ! cranial nerves is_a: UBERON:0002731 ! vestibulocochlear nerve root intersection_of: UBERON:0002731 ! vestibulocochlear nerve root intersection_of: BFO:0000050 NCBITaxon:10090 ! part of Mus musculus relationship: BFO:0000050 MBA:967 ! part of cranial nerves property_value: IAO:0000028 "VIIIn" xsd:string property_value: skos:prefLabel "vestibulocochlear nerve ( mouse )" xsd:string [Term] id: MBA:947 name: Somatomotor areas, Layer 6b synonym: "MO6b" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=1#structure=947 xref: http://atlas.brain-map.org/atlas?atlas=2#structure=947 xref: http://atlas.brain-map.org/atlas?atlas=602630314#structure=947 is_a: MBA:ENTITY is_a: UBERON:8440003 ! cortical layer VIb intersection_of: BFO:0000050 NCBITaxon:10090 {all_some="true"} ! part of Mus musculus intersection_of: BFO:0000050 UBERON:8440076 ! part of somatomotor area relationship: BFO:0000050 MBA:500 ! part of Somatomotor areas property_value: IAO:0000028 "MO6b" xsd:string property_value: skos:prefLabel "Somatomotor areas, Layer 6b ( mouse )" xsd:string [Term] id: MBA:953 name: Pineal body synonym: "PIN" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=1#structure=953 xref: http://atlas.brain-map.org/atlas?atlas=2#structure=953 xref: http://atlas.brain-map.org/atlas?atlas=602630314#structure=953 is_a: MBA:8 ! Basic cell groups and regions is_a: UBERON:0001905 ! pineal body intersection_of: UBERON:0001905 ! pineal body intersection_of: BFO:0000050 NCBITaxon:10090 ! part of Mus musculus relationship: BFO:0000050 MBA:958 ! part of Epithalamus property_value: IAO:0000028 "PIN" xsd:string property_value: skos:prefLabel "Pineal body ( mouse )" xsd:string [Term] id: MBA:956 name: corpus callosum, anterior forceps synonym: "fa" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=1#structure=956 xref: http://atlas.brain-map.org/atlas?atlas=2#structure=956 xref: http://atlas.brain-map.org/atlas?atlas=602630314#structure=956 is_a: BFO:0000004 relationship: BFO:0000050 MBA:776 ! part of corpus callosum relationship: BFO:0000050 NCBITaxon:10090 ! part of Mus musculus relationship: BFO:0000050 UBERON:0034678 ! part of forceps minor of corpus callosum property_value: IAO:0000028 "fa" xsd:string property_value: skos:prefLabel "corpus callosum, anterior forceps ( mouse )" xsd:string [Term] id: MBA:958 name: Epithalamus synonym: "EPI" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=1#structure=958 xref: http://atlas.brain-map.org/atlas?atlas=2#structure=958 xref: http://atlas.brain-map.org/atlas?atlas=602630314#structure=958 is_a: MBA:8 ! Basic cell groups and regions is_a: UBERON:0001899 ! epithalamus intersection_of: UBERON:0001899 ! epithalamus intersection_of: BFO:0000050 NCBITaxon:10090 ! part of Mus musculus relationship: BFO:0000050 MBA:856 ! part of Thalamus, polymodal association cortex related property_value: IAO:0000028 "EPI" xsd:string property_value: skos:prefLabel "Epithalamus ( mouse )" xsd:string [Term] id: MBA:96 name: Dorsal cochlear nucleus synonym: "DCO" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=1#structure=96 xref: http://atlas.brain-map.org/atlas?atlas=2#structure=96 xref: http://atlas.brain-map.org/atlas?atlas=602630314#structure=96 is_a: MBA:ENTITY is_a: UBERON:0002829 ! dorsal cochlear nucleus intersection_of: UBERON:0002829 ! dorsal cochlear nucleus intersection_of: BFO:0000050 NCBITaxon:10090 ! part of Mus musculus relationship: BFO:0000050 MBA:607 ! part of Cochlear nuclei property_value: IAO:0000028 "DCO" xsd:string property_value: skos:prefLabel "Dorsal cochlear nucleus ( mouse )" xsd:string [Term] id: MBA:960 name: cerebellum related fiber tracts synonym: "cbf" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=1#structure=960 xref: http://atlas.brain-map.org/atlas?atlas=2#structure=960 xref: http://atlas.brain-map.org/atlas?atlas=602630314#structure=960 is_a: BFO:0000004 relationship: BFO:0000050 MBA:1009 ! part of fiber tracts property_value: IAO:0000028 "cbf" xsd:string property_value: skos:prefLabel "cerebellum related fiber tracts ( mouse )" xsd:string [Term] id: MBA:967 name: cranial nerves synonym: "cm" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=1#structure=967 xref: http://atlas.brain-map.org/atlas?atlas=2#structure=967 xref: http://atlas.brain-map.org/atlas?atlas=602630314#structure=967 is_a: MBA:1009 ! fiber tracts is_a: UBERON:0006843 ! root of cranial nerve intersection_of: UBERON:0006843 ! root of cranial nerve intersection_of: BFO:0000050 NCBITaxon:10090 ! part of Mus musculus relationship: BFO:0000050 MBA:1009 ! part of fiber tracts property_value: IAO:0000028 "cm" xsd:string property_value: skos:prefLabel "cranial nerves ( mouse )" xsd:string [Term] id: MBA:968 name: Nodulus (X) synonym: "NOD" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=1#structure=968 xref: http://atlas.brain-map.org/atlas?atlas=2#structure=968 xref: http://atlas.brain-map.org/atlas?atlas=602630314#structure=968 is_a: MBA:8 ! Basic cell groups and regions is_a: UBERON:0004083 ! cerebellum vermis lobule X intersection_of: UBERON:0004083 ! cerebellum vermis lobule X intersection_of: BFO:0000050 NCBITaxon:10090 ! part of Mus musculus relationship: BFO:0000050 MBA:645 ! part of Vermal regions property_value: IAO:0000028 "NOD" xsd:string property_value: skos:prefLabel "Nodulus (X) ( mouse )" xsd:string [Term] id: MBA:983 name: lateral forebrain bundle system synonym: "lfbs" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=1#structure=983 xref: http://atlas.brain-map.org/atlas?atlas=2#structure=983 xref: http://atlas.brain-map.org/atlas?atlas=602630314#structure=983 is_a: BFO:0000004 relationship: BFO:0000050 MBA:1009 ! part of fiber tracts property_value: IAO:0000028 "lfbs" xsd:string property_value: skos:prefLabel "lateral forebrain bundle system ( mouse )" xsd:string [Term] id: MBA:985 name: Primary motor area synonym: "MOp" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=1#structure=985 xref: http://atlas.brain-map.org/atlas?atlas=2#structure=985 xref: http://atlas.brain-map.org/atlas?atlas=602630314#structure=985 is_a: MBA:8 ! Basic cell groups and regions is_a: UBERON:0001384 ! primary motor cortex intersection_of: UBERON:0001384 ! primary motor cortex intersection_of: BFO:0000050 NCBITaxon:10090 ! part of Mus musculus relationship: BFO:0000050 MBA:500 ! part of Somatomotor areas property_value: IAO:0000028 "MOp" xsd:string property_value: skos:prefLabel "Primary motor area ( mouse )" xsd:string [Term] id: MBA:987 name: Pons, motor related synonym: "P-mot" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=1#structure=987 xref: http://atlas.brain-map.org/atlas?atlas=2#structure=987 xref: http://atlas.brain-map.org/atlas?atlas=602630314#structure=987 is_a: BFO:0000004 relationship: BFO:0000050 MBA:771 ! part of Pons property_value: IAO:0000028 "P-mot" xsd:string property_value: skos:prefLabel "Pons, motor related ( mouse )" xsd:string [Term] id: MBA:991 name: medial forebrain bundle system synonym: "mfbs" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=1#structure=991 xref: http://atlas.brain-map.org/atlas?atlas=2#structure=991 xref: http://atlas.brain-map.org/atlas?atlas=602630314#structure=991 is_a: BFO:0000004 relationship: BFO:0000050 MBA:1009 ! part of fiber tracts property_value: IAO:0000028 "mfbs" xsd:string property_value: skos:prefLabel "medial forebrain bundle system ( mouse )" xsd:string [Term] id: MBA:993 name: Secondary motor area synonym: "MOs" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=1#structure=993 xref: http://atlas.brain-map.org/atlas?atlas=2#structure=993 xref: http://atlas.brain-map.org/atlas?atlas=602630314#structure=993 is_a: MBA:8 ! Basic cell groups and regions is_a: UBERON:0016634 ! premotor cortex intersection_of: UBERON:0016634 ! premotor cortex intersection_of: BFO:0000050 NCBITaxon:10090 ! part of Mus musculus relationship: BFO:0000050 MBA:500 ! part of Somatomotor areas property_value: IAO:0000028 "MOs" xsd:string property_value: skos:prefLabel "Secondary motor area ( mouse )" xsd:string [Term] id: MBA:997 name: brain synonym: "root" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=1#structure=997 xref: http://atlas.brain-map.org/atlas?atlas=2#structure=997 xref: http://atlas.brain-map.org/atlas?atlas=602630314#structure=997 is_a: MBA:ENTITY is_a: UBERON:0008823 ! neural tube derived brain intersection_of: UBERON:0000955 ! brain intersection_of: BFO:0000050 NCBITaxon:10090 ! part of Mus musculus property_value: IAO:0000028 "root" xsd:string property_value: skos:prefLabel "brain ( mouse )" xsd:string [Term] id: MBA:ENTITY is_a: UBERON:0001062 ! anatomical entity intersection_of: UBERON:0001062 ! anatomical entity intersection_of: BFO:0000050 NCBITaxon:10090 ! part of Mus musculus relationship: BFO:0000050 NCBITaxon:10090 ! part of Mus musculus [Term] id: MOD:00919 is_a: PR:000049928 ! amino-acid residue related to L-tyrosine [Term] id: NCBITaxon:1 name: root namespace: ncbi_taxonomy synonym: "all" RELATED synonym [] xref: GC_ID:1 xref: PMID:30365038 xref: PMID:32761142 property_value: skos:prefLabel "root" xsd:string [Term] id: NCBITaxon:10066 name: Muridae namespace: ncbi_taxonomy xref: GC_ID:1 xref: PMID:15371245 is_a: NCBITaxon:337687 ! Muroidea property_value: skos:prefLabel "Muridae" xsd:string [Term] id: NCBITaxon:10088 name: Mus namespace: ncbi_taxonomy synonym: "mice" EXACT genbank_common_name [] synonym: "mouse" EXACT OMO:0003003 [] synonym: "Mus" EXACT scientific_name [] xref: GC_ID:1 is_a: NCBITaxon:39107 ! Murinae property_value: skos:prefLabel "Mus " xsd:string [Term] id: NCBITaxon:10090 name: Mus musculus namespace: ncbi_taxonomy synonym: "house mouse" EXACT genbank_common_name [] synonym: "mouse" EXACT OMO:0003003 [] xref: GC_ID:1 is_a: NCBITaxon:862507 ! Mus property_value: skos:prefLabel "Mus musculus" xsd:string [Term] id: NCBITaxon:117570 name: Teleostomi namespace: ncbi_taxonomy xref: GC_ID:1 is_a: NCBITaxon:7776 ! Gnathostomata property_value: skos:prefLabel "Teleostomi" xsd:string [Term] id: NCBITaxon:117571 name: Euteleostomi namespace: ncbi_taxonomy synonym: "bony vertebrates" EXACT genbank_common_name [] xref: GC_ID:1 is_a: NCBITaxon:117570 ! Teleostomi property_value: skos:prefLabel "Euteleostomi" xsd:string [Term] id: NCBITaxon:119089 name: Chromadorea namespace: ncbi_taxonomy synonym: "Adenophorea" RELATED synonym [] xref: GC_ID:1 is_a: NCBITaxon:6231 ! Nematoda [Term] id: NCBITaxon:1206794 name: Ecdysozoa namespace: ncbi_taxonomy xref: GC_ID:1 is_a: NCBITaxon:33317 ! Protostomia disjoint_from: NCBITaxon:2697495 ! Spiralia [Term] id: NCBITaxon:1206795 name: Lophotrochozoa namespace: ncbi_taxonomy xref: GC_ID:1 is_a: NCBITaxon:2697495 ! Spiralia [Term] id: NCBITaxon:131567 name: cellular organisms namespace: ncbi_taxonomy synonym: "biota" RELATED synonym [] xref: GC_ID:1 is_a: NCBITaxon:1 ! root property_value: skos:prefLabel "cellular organisms" xsd:string [Term] id: NCBITaxon:1329799 name: Archelosauria namespace: ncbi_taxonomy synonym: "Archosauria-Testudines" RELATED synonym [] synonym: "Testudines + Archosauria group" RELATED synonym [] xref: GC_ID:1 xref: PMID:22839753 xref: PMID:25450099 is_a: NCBITaxon:32561 ! Sauria [Term] id: NCBITaxon:1338369 name: Dipnotetrapodomorpha namespace: ncbi_taxonomy xref: GC_ID:1 is_a: NCBITaxon:8287 ! Sarcopterygii property_value: skos:prefLabel "Dipnotetrapodomorpha" xsd:string [Term] id: NCBITaxon:142796 name: Eumycetozoa namespace: ncbi_taxonomy synonym: "Eumycetozoa Zopf, 1884" RELATED synonym [] synonym: "Mycetozoa" RELATED synonym [] synonym: "mycetozoans" RELATED synonym [] xref: GC_ID:1 xref: PMID:11062127 xref: PMID:9342353 is_a: NCBITaxon:2605435 ! Evosea [Term] id: NCBITaxon:1437010 name: Boreoeutheria namespace: ncbi_taxonomy synonym: "Boreotheria" RELATED synonym [] xref: GC_ID:1 xref: PMID:11743200 xref: PMID:11791233 is_a: NCBITaxon:9347 ! Eutheria property_value: skos:prefLabel "Boreoeutheria" xsd:string [Term] id: NCBITaxon:147554 name: Schizosaccharomycetes namespace: ncbi_taxonomy synonym: "Archiascomycota" RELATED in_part [] xref: GC_ID:1 is_a: NCBITaxon:451866 ! Taphrinomycotina [Term] id: NCBITaxon:186623 name: Actinopteri namespace: ncbi_taxonomy xref: GC_ID:1 is_a: NCBITaxon:7898 ! Actinopterygii [Term] id: NCBITaxon:1963758 name: Myomorpha namespace: ncbi_taxonomy synonym: "mice and others" EXACT genbank_common_name [] synonym: "Sciurognathi" RELATED in_part [] xref: GC_ID:1 is_a: NCBITaxon:9989 ! Rodentia property_value: skos:prefLabel "Myomorpha" xsd:string [Term] id: NCBITaxon:1965096 name: Callithrix namespace: ncbi_taxonomy synonym: "Callithrix" EXACT scientific_name [] xref: GC_ID:1 is_a: NCBITaxon:9481 ! Callithrix [Term] id: NCBITaxon:197562 name: Pancrustacea namespace: ncbi_taxonomy xref: GC_ID:1 xref: PMID:10874751 xref: PMID:11557979 is_a: NCBITaxon:197563 ! Mandibulata [Term] id: NCBITaxon:197563 name: Mandibulata namespace: ncbi_taxonomy synonym: "mandibulates" EXACT OMO:0003003 [] xref: GC_ID:1 xref: PMID:11557979 xref: PMID:9727836 is_a: NCBITaxon:6656 ! Arthropoda [Term] id: NCBITaxon:2 name: Bacteria namespace: ncbi_taxonomy synonym: "bacteria" EXACT genbank_common_name [] synonym: "bacteria" RELATED blast_name [] synonym: "Bacteria (ex Cavalier-Smith 1987)" RELATED synonym [] synonym: "Bacteria Woese et al. 2024" RELATED synonym [] synonym: "Bacteriobiota" RELATED synonym [] synonym: "eubacteria" EXACT OMO:0003003 [] synonym: "Monera" RELATED in_part [] synonym: "Procaryotae" RELATED in_part [] synonym: "Prokaryota" RELATED in_part [] synonym: "Prokaryotae" RELATED in_part [] synonym: "prokaryote" RELATED in_part [] synonym: "prokaryotes" RELATED in_part [] xref: GC_ID:11 xref: PMID:10425795 xref: PMID:10425796 xref: PMID:10425797 xref: PMID:10490293 xref: PMID:10843050 xref: PMID:10939651 xref: PMID:10939673 xref: PMID:10939677 xref: PMID:11211268 xref: PMID:11321083 xref: PMID:11321113 xref: PMID:11411719 xref: PMID:11540071 xref: PMID:11542017 xref: PMID:11542087 xref: PMID:11760965 xref: PMID:12054223 xref: PMID:270744 xref: PMID:32628106 xref: PMID:36748408 xref: PMID:7520741 xref: PMID:8123559 xref: PMID:8186100 xref: PMID:8590690 xref: PMID:9103655 xref: PMID:9336922 is_a: NCBITaxon:131567 ! cellular organisms disjoint_from: NCBITaxon:2759 ! Eukaryota [Term] id: NCBITaxon:207598 name: Homininae namespace: ncbi_taxonomy synonym: "Homo/Pan/Gorilla group" RELATED synonym [] xref: GC_ID:1 is_a: NCBITaxon:9604 ! Hominidae property_value: skos:prefLabel "Homininae" xsd:string [Term] id: NCBITaxon:2172821 name: Multicrustacea namespace: ncbi_taxonomy xref: GC_ID:1 is_a: NCBITaxon:6657 ! Crustacea [Term] id: NCBITaxon:2301116 name: Rhabditina namespace: ncbi_taxonomy xref: GC_ID:1 is_a: NCBITaxon:6236 ! Rhabditida [Term] id: NCBITaxon:2301119 name: Rhabditomorpha namespace: ncbi_taxonomy xref: GC_ID:1 is_a: NCBITaxon:2301116 ! Rhabditina [Term] id: NCBITaxon:2605435 name: Evosea namespace: ncbi_taxonomy xref: GC_ID:1 is_a: NCBITaxon:554915 ! Amoebozoa [Term] id: NCBITaxon:2697495 name: Spiralia namespace: ncbi_taxonomy xref: GC_ID:1 is_a: NCBITaxon:33317 ! Protostomia [Term] id: NCBITaxon:2759 name: Eukaryota namespace: ncbi_taxonomy synonym: "Eucarya" RELATED synonym [] synonym: "Eucaryotae" RELATED synonym [] synonym: "Eukarya" RELATED synonym [] synonym: "Eukaryotae" RELATED synonym [] synonym: "eukaryotes" EXACT genbank_common_name [] synonym: "eukaryotes" RELATED blast_name [] xref: GC_ID:1 xref: PMID:23020233 xref: PMID:30257078 is_a: NCBITaxon:131567 ! cellular organisms property_value: skos:prefLabel "Eukaryota" xsd:string [Term] id: NCBITaxon:314145 name: Laurasiatheria namespace: ncbi_taxonomy xref: GC_ID:1 xref: PMID:11214318 xref: PMID:11214319 xref: PMID:12878460 is_a: NCBITaxon:1437010 ! Boreoeutheria disjoint_from: NCBITaxon:314146 ! Euarchontoglires [Term] id: NCBITaxon:314146 name: Euarchontoglires namespace: ncbi_taxonomy xref: GC_ID:1 xref: PMID:11214319 xref: PMID:12082125 xref: PMID:12878460 xref: PMID:15522813 is_a: NCBITaxon:1437010 ! Boreoeutheria property_value: skos:prefLabel "Euarchontoglires" xsd:string [Term] id: NCBITaxon:314147 name: Glires namespace: ncbi_taxonomy synonym: "Rodents and rabbits" EXACT genbank_common_name [] xref: GC_ID:1 xref: PMID:11214319 xref: PMID:12082125 xref: PMID:15522813 is_a: NCBITaxon:314146 ! Euarchontoglires disjoint_from: NCBITaxon:9443 ! Primates property_value: skos:prefLabel "Glires" xsd:string [Term] id: NCBITaxon:314293 name: Simiiformes namespace: ncbi_taxonomy synonym: "Anthropoidea" RELATED synonym [] xref: GC_ID:1 is_a: NCBITaxon:376913 ! Haplorrhini property_value: skos:prefLabel "Simiiformes" xsd:string [Term] id: NCBITaxon:314295 name: Hominoidea namespace: ncbi_taxonomy synonym: "ape" EXACT OMO:0003003 [] synonym: "apes" EXACT genbank_common_name [] xref: GC_ID:1 is_a: NCBITaxon:9526 ! Catarrhini property_value: skos:prefLabel "Hominoidea" xsd:string [Term] id: NCBITaxon:32443 name: Teleostei namespace: ncbi_taxonomy synonym: "teleost fishes" EXACT genbank_common_name [] xref: GC_ID:1 is_a: NCBITaxon:41665 ! Neopterygii [Term] id: NCBITaxon:32523 name: Tetrapoda namespace: ncbi_taxonomy synonym: "tetrapods" EXACT genbank_common_name [] xref: GC_ID:1 is_a: NCBITaxon:1338369 ! Dipnotetrapodomorpha property_value: skos:prefLabel "Tetrapoda" xsd:string [Term] id: NCBITaxon:32524 name: Amniota namespace: ncbi_taxonomy synonym: "amniotes" EXACT genbank_common_name [] xref: GC_ID:1 is_a: NCBITaxon:32523 ! Tetrapoda property_value: skos:prefLabel "Amniota" xsd:string [Term] id: NCBITaxon:32525 name: Theria namespace: ncbi_taxonomy synonym: "Theria" EXACT scientific_name [] xref: GC_ID:1 is_a: NCBITaxon:40674 ! Mammalia property_value: skos:prefLabel "Theria " xsd:string [Term] id: NCBITaxon:32561 name: Sauria namespace: ncbi_taxonomy synonym: "Diapsida" RELATED synonym [] synonym: "diapsids" EXACT genbank_common_name [] xref: GC_ID:1 is_a: NCBITaxon:8457 ! Sauropsida [Term] id: NCBITaxon:33154 name: Opisthokonta namespace: ncbi_taxonomy synonym: "Fungi/Metazoa group" RELATED synonym [] synonym: "opisthokonts" RELATED synonym [] xref: GC_ID:1 is_a: NCBITaxon:2759 ! Eukaryota disjoint_from: NCBITaxon:554915 ! Amoebozoa property_value: skos:prefLabel "Opisthokonta" xsd:string [Term] id: NCBITaxon:33208 name: Metazoa namespace: ncbi_taxonomy synonym: "Animalia" RELATED synonym [] synonym: "animals" EXACT genbank_common_name [] synonym: "animals" RELATED blast_name [] synonym: "metazoans" EXACT OMO:0003003 [] synonym: "multicellular animals" EXACT OMO:0003003 [] xref: GC_ID:1 is_a: NCBITaxon:33154 ! Opisthokonta disjoint_from: NCBITaxon:4751 ! Fungi property_value: skos:prefLabel "Metazoa" xsd:string [Term] id: NCBITaxon:33213 name: Bilateria namespace: ncbi_taxonomy xref: GC_ID:1 is_a: NCBITaxon:6072 ! Eumetazoa disjoint_from: NCBITaxon:6073 ! Cnidaria property_value: skos:prefLabel "Bilateria" xsd:string [Term] id: NCBITaxon:33317 name: Protostomia namespace: ncbi_taxonomy xref: GC_ID:1 is_a: NCBITaxon:33213 ! Bilateria disjoint_from: NCBITaxon:33511 ! Deuterostomia [Term] id: NCBITaxon:33511 name: Deuterostomia namespace: ncbi_taxonomy synonym: "deuterostomes" EXACT OMO:0003003 [] xref: GC_ID:1 is_a: NCBITaxon:33213 ! Bilateria property_value: skos:prefLabel "Deuterostomia" xsd:string [Term] id: NCBITaxon:33554 name: Carnivora namespace: ncbi_taxonomy synonym: "carnivores" EXACT genbank_common_name [] synonym: "carnivores" RELATED blast_name [] xref: GC_ID:1 is_a: NCBITaxon:314145 ! Laurasiatheria disjoint_from: NCBITaxon:9787 ! Perissodactyla [Term] id: NCBITaxon:337687 name: Muroidea namespace: ncbi_taxonomy xref: GC_ID:1 xref: PMID:15019624 xref: PMID:15371245 is_a: NCBITaxon:1963758 ! Myomorpha property_value: skos:prefLabel "Muroidea" xsd:string [Term] id: NCBITaxon:338152 name: Felinae namespace: ncbi_taxonomy synonym: "Acinonychinae" RELATED in_part [] xref: GC_ID:1 is_a: NCBITaxon:9681 ! Felidae [Term] id: NCBITaxon:34346 name: Schizosaccharomycetales namespace: ncbi_taxonomy xref: GC_ID:1 is_a: NCBITaxon:147554 ! Schizosaccharomycetes [Term] id: NCBITaxon:376913 name: Haplorrhini namespace: ncbi_taxonomy xref: GC_ID:1 is_a: NCBITaxon:9443 ! Primates property_value: skos:prefLabel "Haplorrhini" xsd:string [Term] id: NCBITaxon:379583 name: Feliformia namespace: ncbi_taxonomy xref: GC_ID:1 is_a: NCBITaxon:33554 ! Carnivora [Term] id: NCBITaxon:39107 name: Murinae namespace: ncbi_taxonomy xref: GC_ID:1 is_a: NCBITaxon:10066 ! Muridae property_value: skos:prefLabel "Murinae" xsd:string [Term] id: NCBITaxon:40674 name: Mammalia namespace: ncbi_taxonomy synonym: "mammals" EXACT genbank_common_name [] synonym: "mammals" RELATED blast_name [] xref: GC_ID:1 is_a: NCBITaxon:32524 ! Amniota disjoint_from: NCBITaxon:8457 ! Sauropsida property_value: skos:prefLabel "Mammalia" xsd:string [Term] id: NCBITaxon:41665 name: Neopterygii namespace: ncbi_taxonomy synonym: "Neopterygi" RELATED synonym [] xref: GC_ID:1 is_a: NCBITaxon:186623 ! Actinopteri [Term] id: NCBITaxon:436486 name: Dinosauria namespace: ncbi_taxonomy synonym: "dinosaurs" EXACT OMO:0003003 [] xref: GC_ID:1 is_a: NCBITaxon:8492 ! Archosauria [Term] id: NCBITaxon:436489 name: Saurischia namespace: ncbi_taxonomy xref: GC_ID:1 is_a: NCBITaxon:436486 ! Dinosauria [Term] id: NCBITaxon:436491 name: Theropoda namespace: ncbi_taxonomy xref: GC_ID:1 is_a: NCBITaxon:436489 ! Saurischia [Term] id: NCBITaxon:436492 name: Coelurosauria namespace: ncbi_taxonomy xref: GC_ID:1 is_a: NCBITaxon:436491 ! Theropoda [Term] id: NCBITaxon:451864 name: Dikarya namespace: ncbi_taxonomy xref: GC_ID:1 xref: PMID:15689432 xref: PMID:16151185 xref: PMID:17010206 xref: PMID:17051209 xref: PMID:17572334 is_a: NCBITaxon:4751 ! Fungi [Term] id: NCBITaxon:451866 name: Taphrinomycotina namespace: ncbi_taxonomy xref: GC_ID:1 is_a: NCBITaxon:4890 ! Ascomycota [Term] id: NCBITaxon:4751 name: Fungi namespace: ncbi_taxonomy synonym: "fungi" RELATED blast_name [] synonym: "Mycota" RELATED synonym [] xref: GC_ID:1 xref: PMID:11062127 xref: PMID:12684019 is_a: NCBITaxon:33154 ! Opisthokonta [Term] id: NCBITaxon:4890 name: Ascomycota namespace: ncbi_taxonomy synonym: "ascomycete fungi" EXACT genbank_common_name [] synonym: "ascomycete fungi" RELATED blast_name [] synonym: "sac fungi" EXACT OMO:0003003 [] xref: GC_ID:1 xref: PMID:17572334 is_a: NCBITaxon:451864 ! Dikarya [Term] id: NCBITaxon:4894 name: Schizosaccharomycetaceae namespace: ncbi_taxonomy synonym: "fission yeasts" EXACT genbank_common_name [] synonym: "Schizosaccharomycetoideae" RELATED synonym [] xref: GC_ID:1 is_a: NCBITaxon:34346 ! Schizosaccharomycetales [Term] id: NCBITaxon:4895 name: Schizosaccharomyces namespace: ncbi_taxonomy xref: GC_ID:1 is_a: NCBITaxon:4894 ! Schizosaccharomycetaceae [Term] id: NCBITaxon:4896 name: Schizosaccharomyces pombe namespace: ncbi_taxonomy synonym: "fission yeast" EXACT genbank_common_name [] synonym: "Schizosaccharomyces malidevorans" RELATED synonym [] xref: GC_ID:1 is_a: NCBITaxon:4895 ! Schizosaccharomyces [Term] id: NCBITaxon:50557 name: Insecta namespace: ncbi_taxonomy synonym: "insects" EXACT genbank_common_name [] synonym: "insects" RELATED blast_name [] synonym: "true insects" EXACT OMO:0003003 [] xref: GC_ID:1 is_a: NCBITaxon:6960 ! Hexapoda [Term] id: NCBITaxon:554915 name: Amoebozoa namespace: ncbi_taxonomy xref: GC_ID:1 xref: PMID:23020233 xref: PMID:30257078 is_a: NCBITaxon:2759 ! Eukaryota [Term] id: NCBITaxon:55879 name: Rhabditoidea namespace: ncbi_taxonomy xref: GC_ID:1 is_a: NCBITaxon:2301119 ! Rhabditomorpha [Term] id: NCBITaxon:55885 name: Peloderinae namespace: ncbi_taxonomy xref: GC_ID:1 is_a: NCBITaxon:6243 ! Rhabditidae [Term] id: NCBITaxon:6072 name: Eumetazoa namespace: ncbi_taxonomy xref: GC_ID:1 is_a: NCBITaxon:33208 ! Metazoa property_value: skos:prefLabel "Eumetazoa" xsd:string [Term] id: NCBITaxon:6073 name: Cnidaria namespace: ncbi_taxonomy synonym: "cnidarians" EXACT genbank_common_name [] synonym: "cnidarians" RELATED blast_name [] synonym: "Coelenterata" RELATED in_part [] synonym: "coelenterates" EXACT OMO:0003003 [] xref: GC_ID:1 is_a: NCBITaxon:6072 ! Eumetazoa [Term] id: NCBITaxon:6157 name: Platyhelminthes namespace: ncbi_taxonomy synonym: "flatworm" EXACT OMO:0003003 [] synonym: "flatworms" EXACT genbank_common_name [] synonym: "flatworms" RELATED blast_name [] xref: GC_ID:1 is_a: NCBITaxon:1206795 ! Lophotrochozoa [Term] id: NCBITaxon:6231 name: Nematoda namespace: ncbi_taxonomy synonym: "Nemata" RELATED synonym [] synonym: "nematode" EXACT OMO:0003003 [] synonym: "nematodes" EXACT genbank_common_name [] synonym: "nematodes" RELATED blast_name [] synonym: "roundworm" EXACT OMO:0003003 [] synonym: "roundworms" EXACT OMO:0003003 [] xref: GC_ID:1 is_a: NCBITaxon:1206794 ! Ecdysozoa disjoint_from: NCBITaxon:88770 ! Panarthropoda [Term] id: NCBITaxon:6236 name: Rhabditida namespace: ncbi_taxonomy synonym: "Strongylida" RELATED synonym [] xref: GC_ID:1 is_a: NCBITaxon:119089 ! Chromadorea [Term] id: NCBITaxon:6237 name: Caenorhabditis namespace: ncbi_taxonomy xref: GC_ID:1 is_a: NCBITaxon:55885 ! Peloderinae [Term] id: NCBITaxon:6243 name: Rhabditidae namespace: ncbi_taxonomy xref: GC_ID:1 is_a: NCBITaxon:55879 ! Rhabditoidea [Term] id: NCBITaxon:6656 name: Arthropoda namespace: ncbi_taxonomy synonym: "arthropods" EXACT genbank_common_name [] synonym: "arthropods" RELATED blast_name [] xref: GC_ID:1 is_a: NCBITaxon:88770 ! Panarthropoda [Term] id: NCBITaxon:6657 name: Crustacea namespace: ncbi_taxonomy synonym: "crustaceans" EXACT genbank_common_name [] synonym: "crustaceans" RELATED blast_name [] xref: GC_ID:1 is_a: NCBITaxon:197562 ! Pancrustacea disjoint_from: NCBITaxon:6960 ! Hexapoda [Term] id: NCBITaxon:6681 name: Malacostraca namespace: ncbi_taxonomy xref: GC_ID:1 is_a: NCBITaxon:2172821 ! Multicrustacea [Term] id: NCBITaxon:6682 name: Eucarida namespace: ncbi_taxonomy xref: GC_ID:1 is_a: NCBITaxon:72041 ! Eumalacostraca [Term] id: NCBITaxon:6683 name: Decapoda namespace: ncbi_taxonomy xref: GC_ID:1 is_a: NCBITaxon:6682 ! Eucarida [Term] id: NCBITaxon:6692 name: Pleocyemata namespace: ncbi_taxonomy xref: GC_ID:1 is_a: NCBITaxon:6683 ! Decapoda [Term] id: NCBITaxon:6712 name: Astacidea namespace: ncbi_taxonomy synonym: "Astacura" RELATED synonym [] synonym: "true lobsters and crayfishes" EXACT genbank_common_name [] xref: GC_ID:1 is_a: NCBITaxon:6692 ! Pleocyemata disjoint_from: NCBITaxon:6752 ! Brachyura [Term] id: NCBITaxon:6752 name: Brachyura namespace: ncbi_taxonomy synonym: "short-tailed crabs" EXACT genbank_common_name [] synonym: "true crabs" EXACT OMO:0003003 [] xref: GC_ID:1 is_a: NCBITaxon:6692 ! Pleocyemata [Term] id: NCBITaxon:6960 name: Hexapoda namespace: ncbi_taxonomy synonym: "Atelocerata" RELATED in_part [] synonym: "hexapods" EXACT genbank_common_name [] synonym: "hexapods" RELATED blast_name [] synonym: "Tracheata" RELATED in_part [] synonym: "Uniramia" RELATED in_part [] xref: GC_ID:1 is_a: NCBITaxon:197562 ! Pancrustacea [Term] id: NCBITaxon:72041 name: Eumalacostraca namespace: ncbi_taxonomy xref: GC_ID:1 is_a: NCBITaxon:6681 ! Malacostraca [Term] id: NCBITaxon:7586 name: Echinodermata namespace: ncbi_taxonomy synonym: "echinoderms" EXACT genbank_common_name [] synonym: "echinoderms" RELATED blast_name [] xref: GC_ID:1 is_a: NCBITaxon:33511 ! Deuterostomia disjoint_from: NCBITaxon:7711 ! Chordata [Term] id: NCBITaxon:7711 name: Chordata namespace: ncbi_taxonomy synonym: "chordates" EXACT genbank_common_name [] synonym: "chordates" RELATED blast_name [] xref: GC_ID:1 is_a: NCBITaxon:33511 ! Deuterostomia property_value: skos:prefLabel "Chordata" xsd:string [Term] id: NCBITaxon:7742 name: Vertebrata namespace: ncbi_taxonomy synonym: "Vertebrata" EXACT scientific_name [] synonym: "vertebrates" EXACT genbank_common_name [] synonym: "vertebrates" RELATED blast_name [] xref: GC_ID:1 is_a: NCBITaxon:89593 ! Craniata property_value: skos:prefLabel "Vertebrata " xsd:string [Term] id: NCBITaxon:7776 name: Gnathostomata namespace: ncbi_taxonomy synonym: "Gnathostomata" EXACT scientific_name [] synonym: "jawed vertebrates" EXACT genbank_common_name [] xref: GC_ID:1 is_a: NCBITaxon:7742 ! Vertebrata property_value: skos:prefLabel "Gnathostomata " xsd:string [Term] id: NCBITaxon:7898 name: Actinopterygii namespace: ncbi_taxonomy synonym: "Actinopterygi" RELATED synonym [] synonym: "fish" EXACT OMO:0003003 [] synonym: "fishes" EXACT OMO:0003003 [] synonym: "Osteichthyes" RELATED in_part [] synonym: "ray-finned fishes" EXACT genbank_common_name [] synonym: "ray-finned fishes" RELATED blast_name [] xref: GC_ID:1 is_a: NCBITaxon:117571 ! Euteleostomi disjoint_from: NCBITaxon:8287 ! Sarcopterygii [Term] id: NCBITaxon:8287 name: Sarcopterygii namespace: ncbi_taxonomy xref: GC_ID:1 is_a: NCBITaxon:117571 ! Euteleostomi property_value: skos:prefLabel "Sarcopterygii" xsd:string [Term] id: NCBITaxon:8457 name: Sauropsida namespace: ncbi_taxonomy synonym: "sauropsids" EXACT genbank_common_name [] xref: GC_ID:1 is_a: NCBITaxon:32524 ! Amniota [Term] id: NCBITaxon:8492 name: Archosauria namespace: ncbi_taxonomy xref: GC_ID:1 is_a: NCBITaxon:1329799 ! Archelosauria [Term] id: NCBITaxon:862507 name: Mus namespace: ncbi_taxonomy synonym: "Mus" EXACT scientific_name [] xref: GC_ID:1 is_a: NCBITaxon:10088 ! Mus property_value: skos:prefLabel "Mus " xsd:string [Term] id: NCBITaxon:8782 name: Aves namespace: ncbi_taxonomy synonym: "avian" RELATED synonym [] synonym: "birds" EXACT genbank_common_name [] synonym: "birds" RELATED blast_name [] xref: GC_ID:1 is_a: NCBITaxon:436492 ! Coelurosauria [Term] id: NCBITaxon:88770 name: Panarthropoda namespace: ncbi_taxonomy xref: GC_ID:1 is_a: NCBITaxon:1206794 ! Ecdysozoa [Term] id: NCBITaxon:89593 name: Craniata namespace: ncbi_taxonomy synonym: "Craniata" EXACT scientific_name [] xref: GC_ID:1 is_a: NCBITaxon:7711 ! Chordata property_value: skos:prefLabel "Craniata " xsd:string [Term] id: NCBITaxon:9347 name: Eutheria namespace: ncbi_taxonomy synonym: "eutherian mammals" EXACT OMO:0003003 [] synonym: "placental mammals" EXACT OMO:0003003 [] synonym: "Placentalia" RELATED synonym [] synonym: "placentals" EXACT genbank_common_name [] synonym: "placentals" RELATED blast_name [] xref: GC_ID:1 is_a: NCBITaxon:32525 ! Theria property_value: skos:prefLabel "Eutheria" xsd:string [Term] id: NCBITaxon:9443 name: Primates namespace: ncbi_taxonomy synonym: "Primata" RELATED synonym [] synonym: "primate" EXACT equivalent_name [] synonym: "primates" EXACT genbank_common_name [] synonym: "primates" RELATED blast_name [] xref: GC_ID:1 is_a: NCBITaxon:314146 ! Euarchontoglires property_value: skos:prefLabel "Primates" xsd:string [Term] id: NCBITaxon:9479 name: Platyrrhini namespace: ncbi_taxonomy synonym: "monkey" EXACT OMO:0003003 [] synonym: "monkeys" EXACT OMO:0003003 [] synonym: "New World monkeys" EXACT genbank_common_name [] xref: GC_ID:1 is_a: NCBITaxon:314293 ! Simiiformes disjoint_from: NCBITaxon:9526 ! Catarrhini [Term] id: NCBITaxon:9480 name: Callitrichinae namespace: ncbi_taxonomy synonym: "Callithricidae" RELATED synonym [] synonym: "Callitrichidae" RELATED synonym [] synonym: "marmosets and tamarins" EXACT genbank_common_name [] xref: GC_ID:1 is_a: NCBITaxon:9498 ! Cebidae [Term] id: NCBITaxon:9481 name: Callithrix namespace: ncbi_taxonomy synonym: "Callithrix" EXACT scientific_name [] xref: GC_ID:1 is_a: NCBITaxon:9480 ! Callitrichinae [Term] id: NCBITaxon:9483 name: Callithrix jacchus namespace: ncbi_taxonomy synonym: "Callithrix jacchus jacchus" RELATED synonym [] synonym: "common marmoset" EXACT OMO:0003003 [] synonym: "Simia jacchus" RELATED synonym [] synonym: "white ear-tufted marmoset" EXACT OMO:0003003 [] synonym: "white-tufted-ear marmoset" EXACT genbank_common_name [] xref: GC_ID:1 is_a: NCBITaxon:1965096 ! Callithrix [Term] id: NCBITaxon:9498 name: Cebidae namespace: ncbi_taxonomy xref: GC_ID:1 is_a: NCBITaxon:9479 ! Platyrrhini [Term] id: NCBITaxon:9526 name: Catarrhini namespace: ncbi_taxonomy xref: GC_ID:1 is_a: NCBITaxon:314293 ! Simiiformes property_value: skos:prefLabel "Catarrhini" xsd:string [Term] id: NCBITaxon:9604 name: Hominidae namespace: ncbi_taxonomy synonym: "great apes" EXACT genbank_common_name [] synonym: "Pongidae" RELATED synonym [] xref: GC_ID:1 is_a: NCBITaxon:314295 ! Hominoidea property_value: skos:prefLabel "Hominidae" xsd:string [Term] id: NCBITaxon:9605 name: Homo namespace: ncbi_taxonomy synonym: "humans" EXACT OMO:0003003 [] xref: GC_ID:1 is_a: NCBITaxon:207598 ! Homininae property_value: skos:prefLabel "Homo" xsd:string [Term] id: NCBITaxon:9606 name: Homo sapiens namespace: ncbi_taxonomy synonym: "human" EXACT genbank_common_name [] xref: GC_ID:1 is_a: NCBITaxon:9605 ! Homo property_value: skos:prefLabel "Homo sapiens" xsd:string [Term] id: NCBITaxon:9681 name: Felidae namespace: ncbi_taxonomy synonym: "cat family" EXACT genbank_common_name [] xref: GC_ID:1 is_a: NCBITaxon:379583 ! Feliformia [Term] id: NCBITaxon:9682 name: Felis namespace: ncbi_taxonomy xref: GC_ID:1 is_a: NCBITaxon:338152 ! Felinae [Term] id: NCBITaxon:9685 name: Felis catus namespace: ncbi_taxonomy synonym: "cat" EXACT OMO:0003003 [] synonym: "cats" EXACT OMO:0003003 [] synonym: "domestic cat" EXACT genbank_common_name [] synonym: "Felis domesticus" RELATED synonym [] synonym: "Felis silvestris catus" RELATED synonym [] xref: GC_ID:1 xref: PMID:17600185 xref: PMID:8581300 xref: PMID:8603894 is_a: NCBITaxon:9682 ! Felis [Term] id: NCBITaxon:9787 name: Perissodactyla namespace: ncbi_taxonomy synonym: "odd-toed ungulates" EXACT genbank_common_name [] synonym: "odd-toed ungulates" RELATED blast_name [] xref: GC_ID:1 is_a: NCBITaxon:314145 ! Laurasiatheria [Term] id: NCBITaxon:9788 name: Equidae namespace: ncbi_taxonomy synonym: "horses" EXACT genbank_common_name [] xref: GC_ID:1 is_a: NCBITaxon:9787 ! Perissodactyla [Term] id: NCBITaxon:9789 name: Equus namespace: ncbi_taxonomy synonym: "Amerhippus" RELATED synonym [] synonym: "Asinus" RELATED synonym [] synonym: "Dolichohippus" RELATED synonym [] synonym: "Equus subg. Amerhippus" RELATED synonym [] synonym: "Equus subg. Asinus" RELATED synonym [] synonym: "Equus subg. Dolichohippus" RELATED synonym [] synonym: "Equus subg. Equus" RELATED synonym [] synonym: "Equus subg. Hemionus" RELATED synonym [] synonym: "Equus subg. Hippotigris" RELATED synonym [] synonym: "Equus subgen. Sussemionus" RELATED synonym [] synonym: "Hemionus" RELATED synonym [] synonym: "Hippotigris" RELATED synonym [] synonym: "Sussemionus" RELATED synonym [] xref: GC_ID:1 is_a: NCBITaxon:9788 ! Equidae [Term] id: NCBITaxon:9975 name: Lagomorpha namespace: ncbi_taxonomy synonym: "rabbits & hares" RELATED blast_name [] xref: GC_ID:1 is_a: NCBITaxon:314147 ! Glires disjoint_from: NCBITaxon:9989 ! Rodentia [Term] id: NCBITaxon:9979 name: Leporidae namespace: ncbi_taxonomy synonym: "rabbits and hares" EXACT genbank_common_name [] xref: GC_ID:1 is_a: NCBITaxon:9975 ! Lagomorpha [Term] id: NCBITaxon:9984 name: Oryctolagus namespace: ncbi_taxonomy xref: GC_ID:1 is_a: NCBITaxon:9979 ! Leporidae [Term] id: NCBITaxon:9986 name: Oryctolagus cuniculus namespace: ncbi_taxonomy synonym: "domestic rabbit" EXACT OMO:0003003 [] synonym: "European rabbit" EXACT OMO:0003003 [] synonym: "Japanese white rabbit" EXACT OMO:0003003 [] synonym: "Lepus cuniculus" RELATED synonym [] synonym: "rabbit" EXACT genbank_common_name [] synonym: "rabbits" EXACT OMO:0003003 [] xref: GC_ID:1 is_a: NCBITaxon:9984 ! Oryctolagus [Term] id: NCBITaxon:9989 name: Rodentia namespace: ncbi_taxonomy synonym: "rodent" EXACT OMO:0003003 [] synonym: "rodents" EXACT genbank_common_name [] synonym: "rodents" RELATED blast_name [] xref: GC_ID:1 is_a: NCBITaxon:314147 ! Glires property_value: skos:prefLabel "Rodentia" xsd:string [Term] id: PATO:0000001 name: quality namespace: quality def: "A dependent entity that inheres in a bearer by virtue of how the bearer is related to other entities" [PATOC:GVG] is_a: BFO:0000020 [Term] id: PATO:0000025 name: composition namespace: quality def: "A single physical entity inhering in an bearer by virtue of the bearer's quantities or relative ratios of subparts." [PATOC:GVG] comment: For example calcium composition (which may inhere in bone), haemoglobin composition (which may inhere in blood). subset: attribute_slim subset: scalar_slim synonym: "composed of" EXACT [] synonym: "compositionality" EXACT [] synonym: "content" EXACT [] synonym: "structure, composition" EXACT [] is_a: PATO:0000141 ! structure [Term] id: PATO:0000050 name: life span namespace: quality def: "A time quality inhering in a bearer by virtue of the bearer's expected maximum age." [PATOC:GVG] subset: attribute_slim is_a: PATO:0000165 ! time [Term] id: PATO:0000051 name: morphology namespace: quality def: "A quality of a single physical entity inhering in the bearer by virtue of the bearer's size or shape or structure." [PATOC:GVG] subset: attribute_slim is_a: PATO:0001241 ! physical object quality [Term] id: PATO:0000052 name: shape namespace: quality def: "A morphological quality inhering in a bearer by virtue of the bearer's ratios of distances between its features (points, edges, surfaces and also holes etc)." [PATOC:GVG] comment: Shapes are invariant on size transformations. Shapes can be subdivided into 2D and 3D shapes, We can also make a distinction between shapes of complete self-connected objects, and shapes of parts of objects. subset: attribute_slim synonym: "relational shape quality" EXACT [] is_a: PATO:0000051 ! morphology [Term] id: PATO:0000057 name: occurrence namespace: quality def: "A quality of a single process inhering in a bearer by virtue of the bearer's occurrence." [PATOC:GVG] subset: attribute_slim subset: hpo_slim synonym: "incidence" EXACT [] synonym: "temporal" BROAD [] is_a: PATO:0002323 ! temporal distribution quality [Term] id: PATO:0000068 name: qualitative namespace: quality def: "A quality of an entity that is descriptive or observational, typically not represented numerically." [https://libguides.macalester.edu/c.php?g=527786&p=3608639, https://www.ncbi.nlm.nih.gov/books/NBK470395/] comment: TODO: define this or obsolete it and move children somewhere else. is_a: PATO:0000001 ! quality [Term] id: PATO:0000069 name: deviation (from_normal) namespace: quality def: "A quality inhering in a bearer by virtue of the whether the bearer differs from normal or average." [PATOC:GVG] subset: attribute_slim is_a: PATO:0000068 ! qualitative [Term] id: PATO:0000117 name: size namespace: quality def: "A morphology quality inhering in a bearer by virtue of the bearer's physical magnitude." [WordNet:WordNet] subset: attribute_slim subset: scalar_slim is_a: PATO:0000051 ! morphology [Term] id: PATO:0000136 name: closure namespace: quality def: "A morphological quality pertaining to the degree to which an object contains an opening, aperture, orifice or vent." [PATOC:CJM, PATOC:GVG] subset: attribute_slim is_a: PATO:0000051 ! morphology [Term] id: PATO:0000141 name: structure namespace: quality def: "A morphology quality inhering in a bearer by virtue of the bearer's relative position, shape, arrangements and connectivity of an organism's various parts; the pattern underlying its form." [PATOC:GVG] subset: attribute_slim synonym: "conformation" BROAD [VT:1000738] synonym: "relational structural quality" EXACT [] is_a: PATO:0000051 ! morphology [Term] id: PATO:0000150 name: texture namespace: quality def: "A morphologic quality inhering in a bearer by virtue of the bearer's relative size, organization and distribution of its surface elements or the representation or invention of the appearance of its surface; visual and tactile surface characteristics." [PATOC:GVG] subset: attribute_slim is_a: PATO:0000051 ! morphology [Term] id: PATO:0000165 name: time namespace: quality def: "A quality in which events occur in sequence." [PATOC:GVG] subset: attribute_slim subset: scalar_slim is_a: PATO:0001018 ! physical quality [Term] id: PATO:0000261 name: maturity namespace: quality def: "A quality of a single physical entity which is held by a bearer when the latter exhibits a state of growth, differentiation, or development." [Merriam-Webster:Merriam-Webster] subset: attribute_slim is_a: PATO:0001995 ! organismal quality [Term] id: PATO:0000402 name: branched namespace: quality def: "A branchiness quality inhering in a bearer by virtue of the bearer's having branches." [WordNet:WordNet] subset: cell_quality subset: mpath_slim subset: value_slim synonym: "ramified" EXACT [] synonym: "ramiform" EXACT [] is_a: PATO:0002009 ! branchiness [Term] id: PATO:0000404 name: coiled namespace: quality def: "A shape quality inhering in a bearer by virtue of the bearer's being curled or wound (especially in concentric rings or spirals)." [WordNet:WordNet] subset: cell_quality subset: mpath_slim subset: value_slim synonym: "helical" RELATED [] synonym: "helicoid" RELATED [] synonym: "helicoidal" RELATED [] synonym: "helix-shaped" RELATED [] synonym: "spiral" EXACT [] is_a: PATO:0001794 ! coiling [Term] id: PATO:0000405 name: curled namespace: quality def: "A shape quality inhering in a bearer by virtue of the bearer's having parallel chains in undulate fashion on the border." [PATOC:GVG] subset: cell_quality subset: mpath_slim subset: value_slim is_a: PATO:0000052 ! shape [Term] id: PATO:0000407 name: flat namespace: quality def: "A quality inhering in a bearer by virtue of the bearer's having a horizontal surface without a slope, tilt, or curvature." [web:http\://www.merriam-webster.com/] subset: cell_quality subset: mpath_slim subset: value_slim synonym: "plate-like" RELATED [] is_a: PATO:0002254 ! flattened [Term] id: PATO:0000411 name: circular namespace: quality def: "A shape quality inhering in a bearer by virtue of the bearer's being such that every part of the surface or the circumference is equidistant from the center." [thefreedictionary.com:thefreedictionary.com] subset: cell_quality subset: mpath_slim subset: value_slim synonym: "round" RELATED [] synonym: "rounded" RELATED [] is_a: PATO:0000947 ! elliptic [Term] id: PATO:0000413 name: square namespace: quality def: "A shape quality inhering in a bearer by virtue of the bearer's having an equal-sided rectangular form." [answers.com:answers.com] subset: cell_quality subset: value_slim is_a: PATO:0002317 ! parallelogram [Term] id: PATO:0000460 name: abnormal namespace: quality def: "A quality inhering in a bearer by virtue of the bearer's deviation from normal or average." [PATOC:GVG] subset: abnormal_slim subset: mpath_slim subset: value_slim synonym: "aberrant" RELATED [] synonym: "atypia" RELATED [] synonym: "atypical" RELATED [] synonym: "defective" RELATED [] is_a: PATO:0000069 ! deviation (from_normal) [Term] id: PATO:0000461 name: normal namespace: quality def: "A quality inhering in a bearer by virtue of the bearer's exhibiting no deviation from normal or average." [PATOC:GVG] subset: abnormal_slim subset: mpath_slim subset: value_slim synonym: "average" RELATED [] is_a: PATO:0000068 ! qualitative [Term] id: PATO:0000586 name: increased size namespace: quality def: "A size quality which is relatively high." [PATOC:GVG] subset: value_slim synonym: "big" RELATED [] synonym: "enlarged" RELATED [] synonym: "expanded" RELATED [] synonym: "great" RELATED [] synonym: "large" RELATED [] is_a: PATO:0000117 ! size is_a: PATO:0002305 ! increased object quality intersection_of: PATO:0000117 ! size intersection_of: RO:0015007 PATO:0000461 ! increased in magnitude relative to normal [Term] id: PATO:0000587 name: decreased size namespace: quality def: "A size quality which is relatively low." [PATOC:GVG] subset: value_slim synonym: "hypoplasia" NARROW [] synonym: "reduced" RELATED [] synonym: "small" RELATED [] synonym: "tiny" RELATED [] synonym: "underdeveloped" NARROW [] is_a: PATO:0000117 ! size is_a: PATO:0002303 ! decreased object quality intersection_of: PATO:0000117 ! size intersection_of: RO:0015008 PATO:0000461 ! decreased in magnitude relative to normal [Term] id: PATO:0000588 name: vestigial namespace: quality def: "A quality inhering in a bearer by virtue of the bearer's being a remnant structure from earlier development or evolution." [PATOC:MAH] comment: May be part of an animal (such as an organ or bone) that is no longer used by the species and has therefore become smaller or less developed. subset: value_slim is_a: PATO:0000141 ! structure [Term] id: PATO:0000608 name: closed namespace: quality def: "A morphological quality inhering in a bearer by virtue of the bearer's affording blocked passage or view." [answers.com:answers.com] subset: value_slim synonym: "blocked" RELATED [] is_a: PATO:0000136 ! closure disjoint_from: PATO:0000610 ! open [Term] id: PATO:0000610 name: open namespace: quality def: "A morphological quality inhering in a bearer by virtue of the bearer's affording unobstructed passage or view." [answers.com:answers.com] subset: value_slim is_a: PATO:0000136 ! closure [Term] id: PATO:0000690 name: discontinuous namespace: quality def: "A quality of a single process inhering in a bearer by virtue of the bearer's being marked by breaks or interruptions." [thefreedictionary.com:thefreedictionary.com] subset: value_slim synonym: "intermittent" RELATED [] synonym: "interrupted" EXACT [] is_a: PATO:0000057 ! occurrence [Term] id: PATO:0000947 name: elliptic namespace: quality def: "A spheroid quality inhering in a bearer by virtue of the bearer's being oval with two axes of symmetry, as produced by a conical section." [PATOC:GVG] subset: cell_quality subset: mpath_slim subset: value_slim synonym: "ellipse-shaped" EXACT [] synonym: "ellipsoid" EXACT [] synonym: "elliptical" EXACT [] synonym: "oval" RELATED [] synonym: "ovoid" RELATED [] is_a: PATO:0002318 ! superelliptic [Term] id: PATO:0000957 name: opacity namespace: quality def: "An optical quality which obtains by virtue of the ability of the bearer to absorb visible light." [PATOC:GVG] subset: attribute_slim is_a: PATO:0001300 ! optical quality [Term] id: PATO:0000963 name: opaque namespace: quality def: "A optical quality inhering in a bearer by virtue of the bearer's not being clear; not transmitting or reflecting light or radiant energy." [PATOC:GVG] subset: mpath_slim subset: value_slim synonym: "clouding" RELATED [] synonym: "cloudy" RELATED [] synonym: "non-transparent" EXACT [] is_a: PATO:0000957 ! opacity [Term] id: PATO:0000964 name: transparent namespace: quality def: "A optical quality inhering in a bearer by virtue of the bearer's lacking opacity." [PATOC:GVG] subset: mpath_slim subset: value_slim synonym: "clear" EXACT [] synonym: "hyaline" EXACT [] is_a: PATO:0000957 ! opacity [Term] id: PATO:0000992 name: viscosity namespace: quality def: "A physical quality of a fluid inhering in a bearer by virtue of the bearer's disposition to internal resistance to flow." [PATOC:GVG] subset: attribute_slim subset: disposition_slim is_a: PATO:0001548 ! quality of a liquid [Term] id: PATO:0000998 name: viscous namespace: quality def: "A viscosity quality inhering in a bearer by virtue of the bearer's having viscosity." [PATOC:GVG] subset: disposition_slim subset: mpath_slim subset: value_slim is_a: PATO:0000992 ! viscosity [Term] id: PATO:0001018 name: physical quality namespace: quality def: "A quality of a physical entity that exists through action of continuants at the physical level of organisation in relation to other entities." [PATOC:GVG] subset: attribute_slim synonym: "relational physical quality" EXACT [] xref: Wikipedia:Physical_property is_a: PATO:0001241 ! physical object quality [Term] id: PATO:0001031 name: elasticity namespace: quality def: "A physical quality inhering in a bearer by virtue of the bearer's disposition to recover its size and shape after deformation in any way." [merriam-webster:merriam-webster] subset: attribute_slim subset: disposition_slim subset: scalar_slim is_a: PATO:0001018 ! physical quality [Term] id: PATO:0001171 name: elastic namespace: quality def: "An elasticity quality inhering in a bearer by virtue of the bearer's ability to recover its size and shape after deformation in any way." [merriam-webster:merriam-webster] subset: disposition_slim subset: mpath_slim subset: value_slim is_a: PATO:0001031 ! elasticity [Term] id: PATO:0001185 name: larval namespace: quality def: "A maturity quality inhering in a bearer by virtue of the bearer's indirect development, undergoing metamorphosis." [Wikipedia:http\://en.wikipedia.org/wiki/Larval] subset: value_slim is_a: PATO:0000261 ! maturity [Term] id: PATO:0001190 name: juvenile namespace: quality def: "A maturity quality inhering in a bearer by virtue the bearer's being not fully grown or developed." [thefreedictionary.com:thefreedictionary.com] subset: mpath_slim subset: value_slim is_a: PATO:0000261 ! maturity [Term] id: PATO:0001236 name: process quality namespace: quality def: "A quality which inheres in an process." [PATOC:GVG] comment: See comments of relational quality of a physical entity. synonym: "quality of a process" EXACT [] synonym: "quality of occurrent" EXACT [] synonym: "quality of process" EXACT [] synonym: "relational quality of occurrent" EXACT [] is_a: PATO:0000001 ! quality disjoint_from: PATO:0001241 ! physical object quality [Term] id: PATO:0001241 name: physical object quality namespace: quality def: "A quality which inheres in a continuant." [PATOC:GVG] comment: Relational qualities are qualities that hold between multiple entities. Normal (monadic) qualities such as the shape of a eyeball exist purely as a quality of that eyeball. A relational quality such as sensitivity to light is a quality of that eyeball (and connecting nervous system) as it relates to incoming light waves/particles. synonym: "monadic quality of a continuant" EXACT [] synonym: "monadic quality of an object" NARROW [] synonym: "monadic quality of continuant" NARROW [] synonym: "multiply inhering quality of a physical entity" EXACT [] synonym: "quality of a continuant" EXACT [] synonym: "quality of a single physical entity" EXACT [] synonym: "quality of an object" EXACT [] synonym: "quality of continuant" EXACT [] xref: snap:Quality is_a: PATO:0000001 ! quality [Term] id: PATO:0001292 name: full-spectrum EM radiation quality namespace: quality def: "An EM radiation quality that is independent of the EM wavelength range." [PATOC:GVG] subset: attribute_slim is_a: PATO:0070060 ! quality of interaction of a substance with electromagnetic radiation [Term] id: PATO:0001294 name: radiation reflective quality namespace: quality def: "A scalar EM radiation quality which obtains by the capacity of the bearer to scatter or reflect radiation." [PATOC:GVG] subset: attribute_slim is_a: PATO:0001292 ! full-spectrum EM radiation quality [Term] id: PATO:0001297 name: reflectivity namespace: quality def: "A radiation reflective quality inhering in a bearer by virtue of the ratio of the energy of a wave reflected from its surface to the energy possessed by the wave striking the bearer's surface." [PATOC:GVG] subset: attribute_slim is_a: PATO:0001294 ! radiation reflective quality [Term] id: PATO:0001300 name: optical quality namespace: quality def: "An EM radiation quality in which the EM radiation is within the fiat range of the spectrum visible deemed to be light." [PATOC:GVG] subset: attribute_slim is_a: PATO:0070060 ! quality of interaction of a substance with electromagnetic radiation [Term] id: PATO:0001365 name: spiny namespace: quality def: "A surface feature shape quality inhering in a bearer by virtue of the bearer's having spines, thorns or similar thin projections on its surface." [PATOC:GVG] subset: cell_quality subset: value_slim is_a: PATO:0001925 ! surface feature shape [Term] id: PATO:0001374 name: ploidy namespace: quality def: "A cellular quality inhering in a bearer by virtue of the bearer's number of homologous sets of chromosomes in the nucleus or primary chromosome-containing compartment of the cell, each set essentially coding for all the biological traits of the organism." [Wikipedia:http\://en.wikipedia.org/wiki/Ploidy] subset: attribute_slim is_a: PATO:0001396 ! cellular quality [Term] id: PATO:0001375 name: haploid namespace: quality def: "A ploidy quality inhering in a bearer by virtue of the bearer's containing a single set of homologous chromosomes." [Wikipedia:http\://en.wikipedia.org/wiki/Haploid] subset: cell_quality subset: value_slim is_a: PATO:0001393 ! euploid [Term] id: PATO:0001377 name: polyploid namespace: quality def: "A ploidy quality inhering in a bearer by virtue of the bearer's containing more than two homologous sets of chromosomes." [Wikipedia:http\://en.wikipedia.org/wiki/Polyploid] subset: cell_quality subset: value_slim is_a: PATO:0001393 ! euploid [Term] id: PATO:0001393 name: euploid namespace: quality def: "A ploidy quality inhering in a bearer by virtue of the bearer's containing an integral multiple of the monoploid number, possibly excluding the sex-determining chromosomes." [Wikipedia:http\://en.wikipedia.org/wiki/Euploid] subset: cell_quality subset: value_slim is_a: PATO:0001374 ! ploidy [Term] id: PATO:0001394 name: diploid namespace: quality def: "A ploidy quality inhering in a bearer by virtue of the bearer's having two copies (homologs) of each chromosome, usually one from the mother and one from the father." [Wikipedia:http\://en.wikipedia.org/wiki/Diploid] comment: The exact number may be one or two different from the 2n number and still be classified as diploidy (although with aneuploidy). Nearly all mammals are diploid organisms, although all individuals have some small fraction of cells that are polyploidy. subset: cell_quality subset: value_slim is_a: PATO:0001393 ! euploid [Term] id: PATO:0001396 name: cellular quality namespace: quality def: "A monadic quality of continuant that exists at the cellular level of organisation." [PATOC:GVG] is_a: PATO:0070044 ! anatomical structure quality [Term] id: PATO:0001397 name: cellular potency namespace: quality def: "A cellular quality that arises by virtue of whether the bearer's disposition to differentiate into one or more mature cell types." [PATOC:GVG] subset: attribute_slim subset: disposition_slim is_a: PATO:0001396 ! cellular quality [Term] id: PATO:0001400 name: unipotent namespace: quality def: "A cellular potency that is the capacity to produce only one differentiated cell type." [Wikipedia:http\://en.wikipedia.org/wiki/Unipotent] comment: Unipotent cells have the quality of self-renewal which distinguishes them from non-stem cells. subset: cell_quality subset: disposition_slim subset: value_slim is_a: PATO:0001397 ! cellular potency [Term] id: PATO:0001401 name: oligopotent namespace: quality def: "A cellular potency that is the capacity to form multiple differentiated cell types of a specific lineage and lack self renewing capacity." [PATOC:MAH] comment: Less potent than multipotent, often thought of as precursor or progenitor cell status. subset: cell_quality subset: disposition_slim subset: value_slim is_a: PATO:0001397 ! cellular potency [Term] id: PATO:0001402 name: multipotent namespace: quality def: "A cellular potency that is the capacity to form multiple differentiated cell types." [Wikipedia:http\://en.wikipedia.org/wiki/Multipotent] subset: cell_quality subset: disposition_slim subset: value_slim is_a: PATO:0001397 ! cellular potency [Term] id: PATO:0001404 name: nucleate quality namespace: quality def: "A cellular quality inhering in a bearer by virtue of bearer's number of nuclei." [PATOC:GVG] subset: attribute_slim is_a: PATO:0001396 ! cellular quality [Term] id: PATO:0001405 name: anucleate namespace: quality def: "A nucleate quality inhering in a bearer by virtue of the bearer's having no nucleus." [Biology-online:Biology-online] subset: cell_quality subset: mpath_slim subset: value_slim is_a: PATO:0001404 ! nucleate quality [Term] id: PATO:0001406 name: binucleate namespace: quality def: "A nucleate quality inhering in a bearer by virtue of the bearer's having two nuclei." [Biology-online:Biology-online] subset: cell_quality subset: mpath_slim subset: value_slim is_a: PATO:0001908 ! multinucleate [Term] id: PATO:0001407 name: mononucleate namespace: quality def: "A nucleate quality inhering in a bearer by virtue of the bearer's having one nucleus." [Biology-online:Biology-online] subset: cell_quality subset: mpath_slim subset: value_slim is_a: PATO:0002505 ! nucleated [Term] id: PATO:0001408 name: ciliated namespace: quality def: "A cellular quality inhering in a bearer by virtue of the bearer's having one or more cilia as a part." [PMID:36924208, wikipedia:Cilium] subset: cell_quality subset: value_slim is_a: PATO:0001396 ! cellular quality [Term] id: PATO:0001410 name: striated namespace: quality def: "A shape quality inhering in a bearer by virtue of the bearer's being marked by narrow lines or grooves, usually parallel." [Biology-online:Biology-online] subset: cell_quality subset: mpath_slim subset: value_slim is_a: PATO:0000052 ! shape [Term] id: PATO:0001501 name: immature namespace: quality def: "A quality inhering in a bearer by virtue of the bearer's lacking complete growth, differentiation, or development." [Merriam-Webster:Merriam-Webster] subset: value_slim synonym: "underdeveloped" RELATED [] is_a: PATO:0000261 ! maturity [Term] id: PATO:0001509 name: functionality namespace: quality def: "A quality of a single physical entity that arises by virtue of whether the bearer exhibits the ability to perform a regular function(s)." [PATOC:MAH] subset: attribute_slim subset: disposition_slim subset: scalar_slim is_a: PATO:0001241 ! physical object quality [Term] id: PATO:0001543 name: flexibility namespace: quality def: "A physical quality inhering in a bearer by virtue of the bearer's disposition to being turned, bowed, or twisted without breaking." [merriam-webster:merriam-webster] subset: attribute_slim subset: disposition_slim is_a: PATO:0001546 ! quality of a solid [Term] id: PATO:0001544 name: flexible namespace: quality def: "A physical quality inhering in a bearer by virtue of the bearer's ability of being turned, bowed, or twisted without breaking." [merriam-webster:merriam-webster] subset: disposition_slim subset: value_slim synonym: "bendy" EXACT [] is_a: PATO:0001543 ! flexibility [Term] id: PATO:0001546 name: quality of a solid namespace: quality def: "A physical quality inhering in a bearer by virtue of the bearer's exhibiting the physical characteristics of an entity characterized by particles arranged such that their shape and volume are relatively stable." [Chemistry:http\://chemistry.about.com/od/chemistryglossary/a/soliddefinition.htm] subset: attribute_slim synonym: "solidity" EXACT [] is_a: PATO:0002198 ! quality of a substance [Term] id: PATO:0001547 name: quality of a gas namespace: quality def: "A physical quality inhering in a bearer by virtue of the bearer's exhibiting the physical characteristics of an entity consisting of particles that have neither a defined volume nor defined shape." [Chemistry:http\://chemistry.about.com/od/chemistryglossary/a/gasdefinition.htm, PATOC:GVG] subset: attribute_slim synonym: "gaseous" EXACT [] is_a: PATO:0002198 ! quality of a substance [Term] id: PATO:0001548 name: quality of a liquid namespace: quality def: "A physical quality inhering in an entity exhibiting the physical characteristics of an amorphous (non-crystalline) form of matter between a gas and a solid that has a definite volume, but no definite shape." [url:http\://www.chemistry-dictionary.com/definition/liquid.php] subset: attribute_slim synonym: "liquidity" EXACT [] is_a: PATO:0002198 ! quality of a substance [Term] id: PATO:0001559 name: having extra function namespace: quality def: "A functionality quality which is held by the bearer when the latter is able to perform additional or different function(s)." [PATO:MAH] subset: disposition_slim subset: value_slim synonym: "having supernumerary functions" EXACT [] is_a: PATO:0001509 ! functionality is_a: PATO:0002305 ! increased object quality intersection_of: PATO:0001509 ! functionality intersection_of: RO:0015007 PATO:0000461 ! increased in magnitude relative to normal [Term] id: PATO:0001579 name: contractility namespace: quality def: "A physical quality that is the ability to contract or shrink." [WordNet:WordNet] subset: attribute_slim subset: disposition_slim subset: scalar_slim is_a: PATO:0001018 ! physical quality [Term] id: PATO:0001580 name: increased contractility namespace: quality def: "A contractility which is relatively high." [PATO:GVG] subset: disposition_slim subset: value_slim synonym: "high contractility" EXACT [] is_a: PATO:0001690 ! contractile is_a: PATO:0002305 ! increased object quality intersection_of: PATO:0001690 ! contractile intersection_of: RO:0015007 PATO:0000461 ! increased in magnitude relative to normal [Term] id: PATO:0001581 name: decreased contractility namespace: quality def: "A contractility which is relatively low." [PATO:GVG] subset: disposition_slim subset: value_slim synonym: "low contractility" EXACT [] is_a: PATO:0001690 ! contractile is_a: PATO:0002303 ! decreased object quality intersection_of: PATO:0001690 ! contractile intersection_of: RO:0015008 PATO:0000461 ! decreased in magnitude relative to normal [Term] id: PATO:0001591 name: curvature namespace: quality def: "A surface shape quality inhering in a bearer by virtue of the bearer's exhibiting a degree of bending." [WordNet:WordNet] subset: attribute_slim is_a: PATO:0000052 ! shape [Term] id: PATO:0001603 name: increased life span namespace: quality def: "A life span which is relatively high." [PATO:GVG] synonym: "high life span" EXACT [] is_a: PATO:0000050 ! life span is_a: PATO:0002305 ! increased object quality intersection_of: PATO:0000050 ! life span intersection_of: RO:0015007 PATO:0000461 ! increased in magnitude relative to normal [Term] id: PATO:0001604 name: decreased life span namespace: quality def: "A life span which is relatively low." [PATO:GVG] synonym: "low life span" EXACT [] is_a: PATO:0000050 ! life span is_a: PATO:0002303 ! decreased object quality intersection_of: PATO:0000050 ! life span intersection_of: RO:0015008 PATO:0000461 ! decreased in magnitude relative to normal [Term] id: PATO:0001690 name: contractile namespace: quality def: "A contractility quality inhering in a bearer by virtue of the bearer's ability of contracting or being contracted." [PATOC:GVG] comment: This refers to the disposition of the bearer. subset: disposition_slim subset: value_slim is_a: PATO:0001579 ! contractility [Term] id: PATO:0001693 name: increased viscosity namespace: quality def: "A viscosity which relatively high." [PATOC:GVG] subset: disposition_slim subset: value_slim synonym: "high viscosity" EXACT [] is_a: PATO:0000998 ! viscous is_a: PATO:0002305 ! increased object quality intersection_of: PATO:0000998 ! viscous intersection_of: RO:0015007 PATO:0000461 ! increased in magnitude relative to normal [Term] id: PATO:0001694 name: decreased viscosity namespace: quality def: "A viscosity which relatively low." [PATOC:GVG] subset: disposition_slim subset: value_slim synonym: "low viscosity" EXACT [] is_a: PATO:0000998 ! viscous is_a: PATO:0002303 ! decreased object quality intersection_of: PATO:0000998 ! viscous intersection_of: RO:0015008 PATO:0000461 ! decreased in magnitude relative to normal [Term] id: PATO:0001701 name: mature namespace: quality def: "A quality inhering in a bearer by virtue of the bearer's exhibiting complete growth, differentiation, or development." [Merriam-Webster:Merriam-Webster] subset: value_slim is_a: PATO:0000261 ! maturity [Term] id: PATO:0001735 name: liquid configuration namespace: quality def: "A physical quality inhering in a bearer by virtue of the bearer's parts having the arrangement which exhibits characteristics of liquids." [PATOC:GVG] synonym: "liquid" EXACT [] is_a: PATO:0001548 ! quality of a liquid [Term] id: PATO:0001736 name: solid configuration namespace: quality def: "A physical quality inhering in a bearer by virtue of the bearer's parts having the arrangement which exhibits characteristics of solids." [PATOC:GVG] subset: value_slim synonym: "solid" EXACT [] is_a: PATO:0001546 ! quality of a solid [Term] id: PATO:0001748 name: invaginated namespace: quality def: "A shape quality in which a portion of the outermost boundary of an entity folds in space such that a portion that was originally convex is now concave." [PATOC:GVG] subset: cell_quality subset: mpath_slim subset: value_slim is_a: PATO:0001857 ! concave [Term] id: PATO:0001776 name: increased flexibility namespace: quality def: "A flexibility which is relatively high." [PATOC:GVG] subset: disposition_slim subset: value_slim synonym: "high flexibility" EXACT [] is_a: PATO:0001544 ! flexible is_a: PATO:0002305 ! increased object quality intersection_of: PATO:0001544 ! flexible intersection_of: RO:0015007 PATO:0000461 ! increased in magnitude relative to normal [Term] id: PATO:0001777 name: decreased flexibility namespace: quality def: "A flexibility which is relatively low." [PATOC:GVG] subset: disposition_slim subset: value_slim synonym: "low flexibility" EXACT [] is_a: PATO:0001544 ! flexible is_a: PATO:0002303 ! decreased object quality intersection_of: PATO:0001544 ! flexible intersection_of: RO:0015008 PATO:0000461 ! decreased in magnitude relative to normal [Term] id: PATO:0001794 name: coiling namespace: quality def: "A shape quality inhering in a bearer by virtue of the bearer's being wound in a continuous series of loops." [Online_Dictionary:Online_Dictionary] subset: attribute_slim is_a: PATO:0000052 ! shape [Term] id: PATO:0001795 name: increased coiling namespace: quality def: "A coiling which is relatively high." [PATOC:GVG] subset: cell_quality subset: value_slim synonym: "high coiling" EXACT [] is_a: PATO:0000404 ! coiled is_a: PATO:0002305 ! increased object quality intersection_of: PATO:0000404 ! coiled intersection_of: RO:0015007 PATO:0000461 ! increased in magnitude relative to normal [Term] id: PATO:0001796 name: decreased coiling namespace: quality def: "A coiling which is relatively low." [PATOC:GVG] subset: cell_quality subset: value_slim synonym: "low coiling" EXACT [] is_a: PATO:0000404 ! coiled is_a: PATO:0002303 ! decreased object quality intersection_of: PATO:0000404 ! coiled intersection_of: RO:0015008 PATO:0000461 ! decreased in magnitude relative to normal [Term] id: PATO:0001857 name: concave namespace: quality def: "A shape quality in a bearer by virtue of the bearer's curving inward." [WordNet:WordNet] subset: cell_quality subset: value_slim is_a: PATO:0002005 ! concavity [Term] id: PATO:0001870 name: crescent-shaped namespace: quality def: "A shape quality inhering in a circular disk by virtue of the bearer's having a segment of another circle removed from its edge, so that what remains is a shape enclosed by two circular arcs of different diameters which intersect at two points (usually in such a manner that the enclosed shape does not include the center of the original circle)." [Wikipedia:http\://en.wikipedia.org/wiki/Crescent] subset: cell_quality subset: value_slim synonym: "bow-shaped" RELATED [] synonym: "crescentic" EXACT [] synonym: "lunate" RELATED [] xref: Image:http\://upload.wikimedia.org/wikipedia/commons/7/74/Crescent.svg is_a: PATO:0002006 ! 2-D shape [Term] id: PATO:0001871 name: reniform namespace: quality def: "A concave 3-D shape quality inhering in a bearer by virtue of the bearer's having the shape of a kidney." [ISBN:0881923214] subset: value_slim synonym: "bean shaped" RELATED [] synonym: "kidney-shaped" EXACT [] is_a: PATO:0002008 ! concave 3-D shape [Term] id: PATO:0001872 name: cuboid namespace: quality def: "A convex 3-D shape quality inhering in a bearer by virtue of the bearer's resemblance to a cube (a 3-D shape with a square cross section)." [PATOC:MAH] subset: cell_quality subset: value_slim synonym: "block-like" RELATED [] synonym: "cuboidal" EXACT [] is_a: PATO:0002007 ! convex 3-D shape relationship: RO:0015011 PATO:0000413 ! has cross section square [Term] id: PATO:0001873 name: cylindrical namespace: quality def: "A convex 3-D shape quality inhering in a bearer by virtue of the bearer's exhibiting a consistently-sized round cross section." [PATOC:MAH] subset: cell_quality subset: value_slim synonym: "rod-like" EXACT [] synonym: "rod-shaped" EXACT [] synonym: "tubulate" NARROW [] is_a: PATO:0002007 ! convex 3-D shape relationship: RO:0015011 PATO:0000411 ! has cross section circular [Term] id: PATO:0001874 name: discoid namespace: quality def: "A shape quality inhering in a bearer by virtue of the bearer's being cylindrical, in which the height is less than the diameter." [PATOC:cjm] subset: cell_quality subset: value_slim synonym: "disc-shaped" EXACT [] synonym: "disk-shaped" EXACT [] is_a: PATO:0001873 ! cylindrical [Term] id: PATO:0001908 name: multinucleate namespace: quality def: "A nucleate quality inhering in a bearer by virtue of the bearer's having more than one nucleus." [PATOC:GVG] subset: mpath_slim subset: value_slim is_a: PATO:0002505 ! nucleated [Term] id: PATO:0001910 name: folded namespace: quality def: "A surface feature shape quality inhering in a bearer by virtue of the bearer's one part being layered over another connected part." [PATOC:cjm] subset: value_slim is_a: PATO:0001925 ! surface feature shape [Term] id: PATO:0001925 name: surface feature shape namespace: quality def: "A surface shape quality inhering in a bearer by virtue of the bearer's shape of features present on its surface or outer shell." [PATOC:CJM] comment: This quality either inheres directly in the surface, or in the entity that has the surface. For example, to say that a particular fly wing is curved is shorthand for saying the wing has a surface which is curved. subset: attribute_slim is_a: PATO:0000052 ! shape [Term] id: PATO:0001979 name: lobed namespace: quality def: "A shape quality inhering in a bearer by virtue of the bearer's being partly divided into a determinate number of regions." [ISBN:0881923214] subset: mpath_slim subset: value_slim is_a: PATO:0000052 ! shape [Term] id: PATO:0001987 name: saccular namespace: quality def: "A structural quality inhering in a bearer by virtue of the bearer's having a three dimensional cavity with a narrow or no opening, and often containing an anatomical substance." [PATOC:MAH] subset: value_slim synonym: "sacular" EXACT [] is_a: PATO:0002014 ! structure, cavities [Term] id: PATO:0001988 name: quadrangular namespace: quality def: "A shape quality inhering in a bearer by virtue of the bearer's having four angles and four sides." [url:http\://www.oed.com/] subset: value_slim is_a: PATO:0002006 ! 2-D shape [Term] id: PATO:0001992 name: cellularity namespace: quality def: "An organismal quality inhering in a bearer by virtue of the bearer's consisting cells." [PATOC:GVG] subset: attribute_slim subset: scalar_slim is_a: PATO:0001995 ! organismal quality [Term] id: PATO:0001993 name: multicellular namespace: quality def: "A cellularity quality inhering in a bearer by virtue of the bearer's consisting of more than one cell." [PATOC:GVG] subset: value_slim is_a: PATO:0001992 ! cellularity [Term] id: PATO:0001995 name: organismal quality namespace: quality def: "A quality that inheres in an entire organism or part of an organism." [PATOC:CJM] is_a: PATO:0001241 ! physical object quality [Term] id: PATO:0002005 name: concavity namespace: quality def: "Surface shape that refers to the inward or outward curvature of the surface." [PATOC:MAH] subset: attribute_slim is_a: PATO:0000052 ! shape [Term] id: PATO:0002006 name: 2-D shape namespace: quality def: "A shape that inheres in a 2 dimensional entity, such as a cross section or projection of a 3 dimensional entity." [PATOC:CJM] subset: attribute_slim synonym: "2-D projection" RELATED [] synonym: "cross-sectional" RELATED [] is_a: PATO:0000052 ! shape [Term] id: PATO:0002007 name: convex 3-D shape namespace: quality def: "A complete three dimensional shape in which for every line connecting pair of points on the object is within the object. Or: a shape lacking cavities. Contrast: concave." [PATOC:CJM] comment: Use this term or an is_a child of this term when the entire shape of the object is known. subset: attribute_slim xref: Image:http\://upload.wikimedia.org/wikipedia/commons/0/06/Convex_polygon_illustration1.png is_a: PATO:0002266 ! 3-D shape relationship: RO:0015011 PATO:0002006 ! has cross section 2-D shape [Term] id: PATO:0002008 name: concave 3-D shape namespace: quality def: "A complete three dimensional shape in which there is a line connecting pair of points on the object that lies outside the object. Or: a shape with cavities. Contrast: concave." [PATOC:CJM] subset: attribute_slim xref: Image:http\://en.wikipedia.org/wiki/Image\:Convex_polygon_illustration2.png is_a: PATO:0002266 ! 3-D shape relationship: BFO:0000051 PATO:0001857 ! has part concave [Term] id: PATO:0002009 name: branchiness namespace: quality def: "A shape quality inhering in a bearer by virtue of the degree to which there are subdivisions or offshoots in a bearer entity." [PATOC:MAH] subset: attribute_slim subset: cell_quality is_a: PATO:0000052 ! shape [Term] id: PATO:0002011 name: neoplastic namespace: quality def: "A structural quality which is held by a bearer when the latter's disposition the presence of abnormally proliferating masses of cells." [PATOC:MAH] subset: disposition_slim subset: mpath_slim subset: value_slim synonym: "tumorous" EXACT [] is_a: PATO:0000141 ! structure [Term] id: PATO:0002014 name: structure, cavities namespace: quality def: "A structural quality that inheres in a bearer by virtue of the bearer's containing hollow areas." [PATOC:GVG] subset: attribute_slim is_a: PATO:0000141 ! structure [Term] id: PATO:0002039 name: biconcave namespace: quality def: "A concave quality inhering in a bearer by virtue of the bearer's curving inward on both sides or surfaces." [PATOC:GVG] subset: value_slim is_a: PATO:0001857 ! concave [Term] id: PATO:0002045 name: dendritic namespace: quality def: "A branched quality inhering in a bearer by virtue of the bearer's having smaller branches arising from larger branches. Resembling a tree in branching structure." [PATOC:cvs] subset: value_slim synonym: "dendriform" EXACT [] synonym: "dendroid" EXACT [] synonym: "dendroidal" EXACT [] is_a: PATO:0000402 ! branched property_value: terms:contributor https://orcid.org/0000-0002-2061-091X creation_date: 2009-02-15T08:11:41Z [Term] id: PATO:0002051 name: increased occurrence namespace: quality def: "An occurrence which is relatively high." [PATOC:GVG] synonym: "increased incidence" EXACT [] is_a: PATO:0000057 ! occurrence is_a: PATO:0002304 ! increased process quality intersection_of: PATO:0000057 ! occurrence intersection_of: RO:0015007 PATO:0000461 ! increased in magnitude relative to normal property_value: terms:contributor https://orcid.org/0000-0002-2061-091X creation_date: 2009-03-26T11:10:11Z [Term] id: PATO:0002052 name: decreased occurrence namespace: quality def: "An occurrence which is relatively low." [PATOC:GVG] synonym: "decreased incidence" EXACT [] is_a: PATO:0000057 ! occurrence is_a: PATO:0002302 ! decreased process quality intersection_of: PATO:0000057 ! occurrence intersection_of: RO:0015008 PATO:0000461 ! decreased in magnitude relative to normal property_value: terms:contributor https://orcid.org/0000-0002-2061-091X creation_date: 2009-03-26T11:12:35Z [Term] id: PATO:0002062 name: physical quality of a process namespace: quality subset: attribute_slim is_a: PATO:0001236 ! process quality property_value: terms:contributor https://orcid.org/0000-0002-2061-091X creation_date: 2009-06-05T09:16:46Z [Term] id: PATO:0002064 name: fenestrated namespace: quality def: "A structure quality inhering in a bearer by virtue of the bearer's delimited by a surface with holes." [PATOC:me] subset: cell_quality subset: mpath_slim subset: value_slim is_a: PATO:0000141 ! structure property_value: terms:contributor https://orcid.org/0000-0002-2061-091X creation_date: 2009-07-01T01:46:53Z [Term] id: PATO:0002078 name: hollow namespace: quality def: "A quality inhering in a bearer by virtue of the bearer's having an empty space or cavity within." [url:http\://www.merriam-webster.com/dictionary/hollow] subset: value_slim is_a: PATO:0002014 ! structure, cavities property_value: terms:contributor https://orcid.org/0000-0002-2061-091X creation_date: 2009-09-18T02:19:20Z [Term] id: PATO:0002094 name: basophilic namespace: quality def: "An affinity inhering in an anatomical structure by virtue of the bearer exhibiting a molecular interaction for basic dyes under specific pH conditions." [PATOC:GVG] subset: disposition_slim subset: mpath_slim subset: value_slim is_a: PATO:0070045 ! anatomical histological quality property_value: terms:contributor https://orcid.org/0000-0002-2061-091X creation_date: 2009-10-05T12:05:23Z [Term] id: PATO:0002097 name: neoplastic, malignant namespace: quality def: "A disposition inhering in a tumour by virtue of the bearer's disposition to progress, invade surrounding tissues or metastasize." [PATOC:GVG] subset: disposition_slim subset: mpath_slim subset: value_slim is_a: PATO:0002011 ! neoplastic property_value: terms:contributor https://orcid.org/0000-0002-2061-091X creation_date: 2009-10-05T12:50:22Z [Term] id: PATO:0002124 name: laminar namespace: quality def: "A quality inhering in a bearer by virtue of the bearer's processing the form of a thin plate sheet or layer." [PATOC:GVG] subset: mpath_slim subset: value_slim is_a: PATO:0000141 ! structure property_value: terms:contributor https://orcid.org/0000-0002-2061-091X creation_date: 2009-10-06T04:37:14Z [Term] id: PATO:0002198 name: quality of a substance namespace: quality def: "A quality inhering in a bearer by virtue of its constitution." [PATOC:GVG] subset: attribute_slim is_a: PATO:0001018 ! physical quality property_value: terms:contributor https://orcid.org/0000-0002-2061-091X creation_date: 2010-03-15T04:35:27Z [Term] id: PATO:0002226 name: subcylindrical namespace: quality def: "A cylindrical shape quality inhering in a bearer by virtue of the bearer's being imperfectly cylindrical or approximately cylindrical." [url:http\://www.thefreedictionary.com/Subcylindrical] subset: value_slim is_a: PATO:0001873 ! cylindrical property_value: terms:contributor https://orcid.org/0000-0002-2061-091X creation_date: 2010-07-13T04:22:30Z [Term] id: PATO:0002254 name: flattened namespace: quality def: "A quality inhering in a bearer by virtue of the bearer's surface becoming more extended in a plane." [PATOC:CVS] comment: Becoming flat but not necessarily completely flat. subset: value_slim synonym: "compressed" RELATED [] is_a: PATO:0001591 ! curvature property_value: terms:contributor https://orcid.org/0000-0002-2061-091X creation_date: 2010-08-16T03:59:34Z [Term] id: PATO:0002255 name: grooved namespace: quality def: "Texture quality inhering in a bearer by virtue of the bearer's being marked with one or more channels." [PATOC:JE] subset: value_slim synonym: "channeled" RELATED [] synonym: "creased" RELATED [] is_a: PATO:0000150 ! texture property_value: terms:contributor https://orcid.org/0000-0002-2061-091X creation_date: 2010-09-01T10:27:48Z [Term] id: PATO:0002266 name: 3-D shape namespace: quality def: "A shape that inheres in a 3 dimensional entity." [PATOC:OREGON] is_a: PATO:0000052 ! shape property_value: terms:contributor https://orcid.org/0000-0002-2061-091X creation_date: 2010-10-05T12:31:16Z [Term] id: PATO:0002287 name: increased elasticity namespace: quality def: "An elasticity which is relatively high." [PATOC:GVG] subset: value_slim is_a: PATO:0001171 ! elastic is_a: PATO:0002305 ! increased object quality intersection_of: PATO:0001171 ! elastic intersection_of: RO:0015007 PATO:0000461 ! increased in magnitude relative to normal property_value: terms:contributor https://orcid.org/0000-0002-2061-091X creation_date: 2011-03-30T11:50:21Z [Term] id: PATO:0002288 name: decreased elasticity namespace: quality def: "An elasticity which is relatively low." [PATOC:GVG] subset: value_slim is_a: PATO:0001171 ! elastic is_a: PATO:0002303 ! decreased object quality intersection_of: PATO:0001171 ! elastic intersection_of: RO:0015008 PATO:0000461 ! decreased in magnitude relative to normal property_value: terms:contributor https://orcid.org/0000-0002-2061-091X creation_date: 2011-03-30T11:50:39Z [Term] id: PATO:0002299 name: tubular namespace: quality def: "A cylindrical shape that is hollow." [PATOC:GVG] synonym: "tube like" EXACT [] synonym: "tube-shaped" EXACT [] synonym: "tubulate" EXACT [] is_a: PATO:0001873 ! cylindrical is_a: PATO:0002078 ! hollow property_value: terms:contributor https://orcid.org/0000-0002-2061-091X creation_date: 2011-06-08T06:33:50Z [Term] id: PATO:0002300 name: increased quality namespace: quality def: "A quality that has a value that is increased compared to normal or average." [PATOC:GVG] is_a: PATO:0000069 ! deviation (from_normal) intersection_of: PATO:0000001 ! quality intersection_of: RO:0015007 PATO:0000461 ! increased in magnitude relative to normal relationship: RO:0015007 PATO:0000461 ! increased in magnitude relative to normal property_value: terms:contributor https://orcid.org/0000-0002-2061-091X creation_date: 2011-06-16T06:39:43Z [Term] id: PATO:0002301 name: decreased quality namespace: quality def: "A quality that has a value that is decreased compared to normal or average." [PATOC:GVG] is_a: PATO:0000069 ! deviation (from_normal) intersection_of: PATO:0000001 ! quality intersection_of: RO:0015008 PATO:0000461 ! decreased in magnitude relative to normal relationship: RO:0015008 PATO:0000461 ! decreased in magnitude relative to normal property_value: terms:contributor https://orcid.org/0000-0002-2061-091X creation_date: 2011-06-16T06:40:15Z [Term] id: PATO:0002302 name: decreased process quality namespace: quality def: "A quality of a process that has a value that is decreased compared to normal or average." [PATOC:GVG] is_a: PATO:0001236 ! process quality is_a: PATO:0002301 ! decreased quality intersection_of: PATO:0001236 ! process quality intersection_of: RO:0015008 PATO:0000461 ! decreased in magnitude relative to normal property_value: terms:contributor https://orcid.org/0000-0002-2061-091X creation_date: 2011-06-16T06:50:59Z [Term] id: PATO:0002303 name: decreased object quality namespace: quality def: "A quality of an object that has a value that is decreased compared to normal or average." [PATOC:GVG] is_a: PATO:0001241 ! physical object quality is_a: PATO:0002301 ! decreased quality intersection_of: PATO:0001241 ! physical object quality intersection_of: RO:0015008 PATO:0000461 ! decreased in magnitude relative to normal property_value: terms:contributor https://orcid.org/0000-0002-2061-091X creation_date: 2011-06-16T06:51:54Z [Term] id: PATO:0002304 name: increased process quality namespace: quality def: "A quality of a process that has a value that is increased compared to normal or average." [PATOC:GVG] is_a: PATO:0001236 ! process quality is_a: PATO:0002300 ! increased quality intersection_of: PATO:0001236 ! process quality intersection_of: RO:0015007 PATO:0000461 ! increased in magnitude relative to normal property_value: terms:contributor https://orcid.org/0000-0002-2061-091X creation_date: 2011-06-16T06:53:08Z [Term] id: PATO:0002305 name: increased object quality namespace: quality def: "A quality of an object that has a value that is increased compared to normal or average." [PATOC:GVG] is_a: PATO:0001241 ! physical object quality is_a: PATO:0002300 ! increased quality intersection_of: PATO:0001241 ! physical object quality intersection_of: RO:0015007 PATO:0000461 ! increased in magnitude relative to normal property_value: terms:contributor https://orcid.org/0000-0002-2061-091X creation_date: 2011-06-16T06:54:01Z [Term] id: PATO:0002309 name: fiber shaped namespace: quality def: "A convex 3-D shape quality inhering in a bearer by virtue of the bearer's exhibiting a by virtue of the bearer's exhibiting a consistently sized and approximately round cross-section along its length, which is many times larger than its diameter." [PATOC:DC] comment: Note that a fiber shaped object may take any circuitous or straight path through space (think of a length of string or rope). subset: value_slim is_a: PATO:0002226 ! subcylindrical property_value: terms:contributor https://orcid.org/0000-0002-2061-091X creation_date: 2011-09-09T04:50:10Z [Term] id: PATO:0002317 name: parallelogram namespace: quality def: "A convex quadrilateral is a parallelogram if and only if any one of the following statements are true:\n1. Each diagonal divides the quadrilateral into two congruent triangles with the same orientation.\n2. The opposite sides are congruent in pairs.\n3. The diagonals bisect each other.\n4. The opposite angles are congruent in pairs.\n5. The sum of the squares of the sides equals the sum of the squares of the diagonals. (This is the parallelogram law)\n6.It possesses rotational symmetry.\n7.One pair of opposite sides are parallel and congruent.\n8.Two pairs of adjacent angles are supplementary." [wikipedia:Parallelogram] subset: value_slim is_a: PATO:0001988 ! quadrangular property_value: terms:contributor https://orcid.org/0000-0002-2061-091X creation_date: 2011-10-12T12:33:07Z [Term] id: PATO:0002318 name: superelliptic namespace: quality def: "A shape constituting a transition between a rectangle and a circle; a closed curve, of which the circle and ellipse are special cases, whose parametric equation is x = a.cos2/rt, y = b.cos2/rt" [wiktionary:superellipse] synonym: "Lamé curve" EXACT [] is_a: PATO:0002006 ! 2-D shape property_value: terms:contributor https://orcid.org/0000-0002-2061-091X creation_date: 2011-10-12T12:45:16Z [Term] id: PATO:0002323 name: temporal distribution quality namespace: quality def: "A temporal distribution pattern of process occurrences within a regulation/reference process." [PATOC:LC] subset: attribute_slim is_a: PATO:0002062 ! physical quality of a process property_value: terms:contributor https://orcid.org/0000-0002-2061-091X creation_date: 2011-11-22T01:12:28Z [Term] id: PATO:0002353 name: activation quality namespace: quality def: "A quality that inheres in a bearer in virtue of its realizing one of its functions." [PATOC:RH] subset: attribute_slim is_a: PATO:0001509 ! functionality property_value: terms:contributor https://orcid.org/0000-0002-2061-091X creation_date: 2012-01-31T04:51:42Z [Term] id: PATO:0002354 name: active namespace: quality def: "A quality of an physical object that is currently realizing one of its functions." [PATOC:RH] subset: attribute_slim is_a: PATO:0002353 ! activation quality property_value: terms:contributor https://orcid.org/0000-0002-2061-091X creation_date: 2012-01-31T04:52:04Z [Term] id: PATO:0002418 name: acidophilic namespace: quality def: "An affinity inhering in an anatomical structure by virtue of the bearer exhibiting a molecular interaction for acidic dyes under specific pH conditions." [PATOC:GVG] comment: Eosin stains acidophilic structures, hence eosinophilic is the same as acidophilic. subset: mpath_slim subset: value_slim synonym: "eosinophilic" EXACT [] is_a: PATO:0070045 ! anatomical histological quality property_value: terms:contributor https://orcid.org/0000-0002-2061-091X creation_date: 2012-12-17T03:01:19Z [Term] id: PATO:0002420 name: amphiphilic namespace: quality def: "Having both hydrophilic and hydrophobic (or lipophilic) groups." [wikipedia:http\://en.wiktionary.org/wiki/amphiphilic] subset: mpath_slim subset: value_slim is_a: PATO:0070045 ! anatomical histological quality property_value: terms:contributor https://orcid.org/0000-0002-2061-091X creation_date: 2012-12-17T03:04:39Z [Term] id: PATO:0002422 name: acinar namespace: quality def: "Pertaining to the individual parts making up an aggregate fruit like a many-lobed \"berry,\" such as a raspberry." [wikipedia:https\://en.wikipedia.org/wiki/Acinus] comment: Acinus is Latin for berry. subset: mpath_slim subset: value_slim is_a: PATO:0000141 ! structure property_value: terms:contributor https://orcid.org/0000-0002-2061-091X creation_date: 2012-12-17T03:11:10Z [Term] id: PATO:0002444 name: mineralized namespace: quality def: "A composition quality inhering in a bearer by virtue of the bearer's being composed of or possessing inorganic material." [PATOC:WC] subset: value_slim is_a: PATO:0000025 ! composition property_value: terms:contributor https://orcid.org/0000-0002-2061-091X creation_date: 2013-01-29T11:03:49Z [Term] id: PATO:0002462 name: collagenous namespace: quality def: "A composition quality inhering in an bearer by virtue of the bearer's consisting of collagen." [PATOC:WD] subset: value_slim is_a: PATO:0000025 ! composition property_value: terms:contributor https://orcid.org/0000-0002-2061-091X creation_date: 2013-09-15T11:34:15Z [Term] id: PATO:0002468 name: distensible namespace: quality def: "A structure quality inhering in a bearer by virtue of the bearer's being capable of swelling or stretching." [PATOC:WD] subset: value_slim is_a: PATO:0015008 ! distensibility property_value: terms:contributor https://orcid.org/0000-0002-2061-091X creation_date: 2013-09-15T11:48:26Z [Term] id: PATO:0002478 name: transversely striated namespace: quality def: "A shape quality inhering in a bearer by virtue of the bearer's being marked by narrow lines or grooves, usually parallel, that are oriented transversely relative to the long axis of the bearer." [PATOC:DS] subset: cell_quality subset: mpath_slim subset: value_slim is_a: PATO:0001410 ! striated property_value: terms:contributor https://orcid.org/0000-0002-2061-091X creation_date: 2013-09-15T12:29:15Z [Term] id: PATO:0002479 name: obliquely striated namespace: quality def: "A shape quality inhering in a bearer by virtue of the bearer's being marked by narrow lines or grooves, usually parallel, that are oriented obliquely relative to the long axis of the bearer." [PATOC:DS] subset: cell_quality subset: mpath_slim subset: value_slim is_a: PATO:0001410 ! striated property_value: terms:contributor https://orcid.org/0000-0002-2061-091X creation_date: 2013-09-15T12:29:42Z [Term] id: PATO:0002487 name: single organismal process quality namespace: quality def: "A quality inhering in a process by virtue of that process having exactly one organism as a participant." [PATOC:DS] subset: attribute_slim is_a: PATO:0001236 ! process quality property_value: terms:contributor https://orcid.org/0000-0002-2061-091X creation_date: 2013-10-10T04:09:51Z [Term] id: PATO:0002505 name: nucleated namespace: quality def: "A nucleate quality inhering in a bearer by virtue of the bearer's having one or more nucleus." [PATOC:GVG] subset: mpath_slim subset: value_slim is_a: PATO:0001404 ! nucleate quality property_value: terms:contributor https://orcid.org/0000-0002-2061-091X creation_date: 2013-10-21T05:44:34Z [Term] id: PATO:0002506 name: alobate namespace: quality def: "A surface feature shape quality inhering in a bearer by virtue of the bearer's not having undulating edges forming lobes." [PATOC:DOS] subset: value_slim is_a: PATO:0001925 ! surface feature shape property_value: terms:contributor https://orcid.org/0000-0002-2061-091X creation_date: 2013-10-25T04:42:40Z [Term] id: PATO:0002507 name: keratinous namespace: quality def: "A composition quality inhering in a bearer by virtue of the bearer's consisting of keratin." [PATOC:EJS] subset: value_slim is_a: PATO:0000025 ! composition property_value: terms:contributor https://orcid.org/0000-0002-9611-1279 creation_date: 2014-02-04T12:38:14Z [Term] id: PATO:0010001 name: disconnected namespace: quality def: "A structural quality inhering in the bearer by virtue of the bearer consisting of multiple structures lacking any physical connection to each other." [GOC:dos] is_a: PATO:0000141 ! structure property_value: terms:contributor https://orcid.org/0000-0002-7073-9172 creation_date: 2014-12-12T08:43:17Z [Term] id: PATO:0010006 name: cell morphology namespace: quality def: "A quality of a single cell inhering in the bearer by virtue of the bearer's size or shape or structure." [https://orcid.org/0000-0002-7073-9172] comment: Use this term for morphologies that can *only* inhere in a cell, e.g. morphological qualities inhering in a cell by virtue of the presence, location or shape of one or more cell parts. is_a: PATO:0000051 ! morphology property_value: terms:contributor https://orcid.org/0000-0002-7073-9172 creation_date: 2021-01-23T11:31:53Z [Term] id: PATO:0010007 name: multiciliated namespace: quality def: "A cellular quality inhering in a bearer by virtue of the bearer's having multiple cilia." [PMID:36924208] is_a: PATO:0001408 ! ciliated property_value: terms:contributor https://orcid.org/0000-0002-7073-9172 property_value: terms:date "2024-07-23T10:43:20Z" xsd:dateTime [Term] id: PATO:0015006 name: polymeric namespace: quality def: "A quality inhering in a structure by virtue of it consisting of many of repeated, similar or identical subunits, arranged in some orderly array." [GOC:DOS, https://github.com/pato-ontology/pato/issues/78] comment: A complete coverage of this domain would subclasses homopolymeric, copolymeric, crystalline. subset: value_slim is_a: PATO:0000141 ! structure [Term] id: PATO:0015008 name: distensibility namespace: quality def: "A quality inhering in a bearer by virtue of the extent to which the bearer is capable of being stretched or swollen." [GOC:CJM] subset: attribute_slim is_a: PATO:0000141 ! structure [Term] id: PATO:0040072 name: high nuclear/cytoplasmic ratio namespace: quality def: "A quality inhering in a cell by virtue of the cell having a high nuclear/cytoplasmic ratio." [http://lymerick.net/blood-cells.pdf, Wikipedia:NC_ratio&oldid=931936284] comment: A high nuclear/cytolasmic ratio is 70% or higher. synonym: "high N:C ratio" EXACT [] is_a: PATO:0001396 ! cellular quality [Term] id: PATO:0045001 name: normal object quality namespace: quality def: "A quality of an object that has a value that is normal or average." [] is_a: PATO:0001241 ! physical object quality intersection_of: PATO:0001241 ! physical object quality intersection_of: RO:0015010 PATO:0000461 ! has relative magnitude normal relationship: RO:0015010 PATO:0000461 ! has relative magnitude normal property_value: terms:contributor https://orcid.org/0000-0001-9227-0670 creation_date: 2017-12-21T14:11:01Z [Term] id: PATO:0045009 name: normal coiling namespace: quality def: "A coiling which is normal or average." [] subset: cell_quality subset: value_slim is_a: PATO:0000404 ! coiled is_a: PATO:0045001 ! normal object quality intersection_of: PATO:0000404 ! coiled intersection_of: RO:0015010 PATO:0000461 ! has relative magnitude normal property_value: terms:contributor https://orcid.org/0000-0001-9227-0670 creation_date: 2017-12-22T14:16:43Z [Term] id: PATO:0045011 name: normal contractility namespace: quality def: "A contractility which is relatively normal or average." [] subset: disposition_slim subset: value_slim is_a: PATO:0001690 ! contractile is_a: PATO:0045001 ! normal object quality intersection_of: PATO:0001690 ! contractile intersection_of: RO:0015010 PATO:0000461 ! has relative magnitude normal property_value: terms:contributor https://orcid.org/0000-0001-9227-0670 creation_date: 2017-12-22T14:16:43Z [Term] id: PATO:0045016 name: normal elasticity namespace: quality def: "An elasticity which is relatively normal or average." [] subset: value_slim is_a: PATO:0001171 ! elastic is_a: PATO:0045001 ! normal object quality intersection_of: PATO:0001171 ! elastic intersection_of: RO:0015010 PATO:0000461 ! has relative magnitude normal property_value: terms:contributor https://orcid.org/0000-0001-9227-0670 creation_date: 2017-12-22T14:16:43Z [Term] id: PATO:0045021 name: normal flexibility namespace: quality def: "A flexibility which is relatively normal or average." [] subset: disposition_slim subset: value_slim is_a: PATO:0001544 ! flexible is_a: PATO:0045001 ! normal object quality intersection_of: PATO:0001544 ! flexible intersection_of: RO:0015010 PATO:0000461 ! has relative magnitude normal property_value: terms:contributor https://orcid.org/0000-0001-9227-0670 creation_date: 2017-12-22T14:16:43Z [Term] id: PATO:0045026 name: normal life span namespace: quality def: "A life span which is relatively normal or average." [] is_a: PATO:0000050 ! life span is_a: PATO:0045001 ! normal object quality intersection_of: PATO:0000050 ! life span intersection_of: RO:0015010 PATO:0000461 ! has relative magnitude normal property_value: terms:contributor https://orcid.org/0000-0001-9227-0670 creation_date: 2017-12-22T14:16:43Z [Term] id: PATO:0045050 name: normal size namespace: quality def: "A size quality which is relatively normal or average" [] subset: value_slim is_a: PATO:0000117 ! size is_a: PATO:0045001 ! normal object quality intersection_of: PATO:0000117 ! size intersection_of: RO:0015010 PATO:0000461 ! has relative magnitude normal property_value: terms:contributor https://orcid.org/0000-0001-9227-0670 creation_date: 2017-12-22T14:16:43Z [Term] id: PATO:0045073 name: normal process quality namespace: quality def: "A quality of a process that has a value that is normal or average." [] is_a: PATO:0001236 ! process quality intersection_of: PATO:0001236 ! process quality intersection_of: RO:0015010 PATO:0000461 ! has relative magnitude normal relationship: RO:0015010 PATO:0000461 ! has relative magnitude normal property_value: terms:contributor https://orcid.org/0000-0001-9227-0670 creation_date: 2017-12-21T14:11:01Z [Term] id: PATO:0045081 name: normal viscosity namespace: quality def: "A viscosity which is relatively normal or average" [] subset: value_slim is_a: PATO:0000998 ! viscous is_a: PATO:0045001 ! normal object quality intersection_of: PATO:0000998 ! viscous intersection_of: RO:0015010 PATO:0000461 ! has relative magnitude normal property_value: terms:contributor https://orcid.org/0000-0001-9227-0670 creation_date: 2017-12-22T14:16:43Z [Term] id: PATO:0045086 name: normal occurrence namespace: quality def: "An occurrence which is relatively normal." [] subset: value_slim is_a: PATO:0000057 ! occurrence is_a: PATO:0045073 ! normal process quality intersection_of: PATO:0000057 ! occurrence intersection_of: RO:0015010 PATO:0000461 ! has relative magnitude normal [Term] id: PATO:0070001 name: neurogliaform morphology namespace: quality def: "A cell morphology that inheres in neurons which have a small round soma, a large number of short, smooth, or slightly beaded primary dendrites that give rise to only a few secondary branches, and a branched axon that establishes a dense axonal mesh with thin shafts." [PMID:17122314] xref: ilxtr:NeurogliaformPhenotype is_a: PATO:0070026 ! multipolar neuron morphology property_value: terms:contributor https://orcid.org/0000-0001-7258-9596 [Term] id: PATO:0070002 name: basket cell morphology namespace: quality def: "A cell morphology that inheres in multipolar neurons with densely branched terminal axonal arborizations that form basket-like structures surrounding and synapsing to the somas of target cells." [doi:10.1016/b978-0-12-369497-3.10004-4, WikipediaVersioned:Basket_cell&oldid=951703880] xref: ILX:0101123 xref: ilxtr:BasketPhenotype xref: nifext:3 is_a: PATO:0070026 ! multipolar neuron morphology property_value: terms:contributor https://orcid.org/0000-0001-7258-9596 [Term] id: PATO:0070003 name: small basket cell morphology namespace: quality def: "A basket cell morphology that inheres in neurons with axonal arbors composed of frequent, short, curvy axonal branches that tend to be near their somata and within the same layer." [PMID:11884355] xref: ilxtr:SmallBasketPhenotype is_a: PATO:0070002 ! basket cell morphology property_value: terms:contributor https://orcid.org/0000-0001-7258-9596 [Term] id: PATO:0070004 name: large basket cell morphology namespace: quality def: "A basket cell morphology that inheres in neurons that are large, and typically ascend to give rise to many long horizontally and vertically projecting axon collaterals that traverse neighboring columns and can extend through all cortical layers." [PMID:11884355] xref: ilxtr:LargeBasketPhenotype is_a: PATO:0070002 ! basket cell morphology property_value: terms:contributor https://orcid.org/0000-0001-7258-9596 [Term] id: PATO:0070005 name: nest basket cell morphology namespace: quality def: "A basket cell morphology that inheres in neurons which have simpler dendritic arbors (compared to small or large basket cell morphology), and an axonal plexus of intermediate density, composed of a few long, smooth axonal branches." [PMID:11884355] xref: ilxtr:NestBasketPhenotype is_a: PATO:0070002 ! basket cell morphology property_value: terms:contributor https://orcid.org/0000-0001-7258-9596 [Term] id: PATO:0070006 name: cortical bipolar morphology namespace: quality def: "A cell morphology that inheres in neurons which have two principal dendrites that emerge from the soma and begin to branch some distance from it, have few spines, and branch in narrow fields. This is in contrast to bitufted morphology where branching occurs close to the soma." [doi:10.1016/b978-0-12-369497-3.10004-4, PMID:18568015] comment: This is specific to cortical bipolar cells and are distinguished from retinal bipolar cell morphology which has an axon and dendrite emerging from opposite ends of the soma. xref: ILX:0101312 xref: ilxtr:BipolarPhenotype xref: nifext:2 is_a: PATO:0070027 ! bitufted dendrite cell morphology property_value: terms:contributor https://orcid.org/0000-0001-7258-9596 [Term] id: PATO:0070007 name: Martinotti morphology namespace: quality def: "A cell morphology that inheres in neurons which are large and non-spiny, with dendrites radiating in a multipolar or bitufted pattern, often favouring the descending side, and axons that ascend directly from the superficial side of the soma, and travel upward without branching." [doi:10.1016/b978-0-12-369497-3.10004-4] xref: ilxtr:MartinottiPhenotype is_a: PATO:0070026 ! multipolar neuron morphology property_value: terms:contributor https://orcid.org/0000-0001-7258-9596 [Term] id: PATO:0070008 name: T Martinotti morphology namespace: quality def: "A Martinotti cell morphology that inheres in neurons which have axons that form a horizontal ramification, making it T-shaped." [doi:10.1016/b978-0-12-369497-3.10004-4] synonym: "'T-shaped' Martinotti morphology" EXACT [] is_a: PATO:0070007 ! Martinotti morphology property_value: terms:contributor https://orcid.org/0000-0001-7258-9596 [Term] id: PATO:0070009 name: fan Martinotti morphology namespace: quality def: "A Martinotti cell morphology that inheres in neurons which have axons that form a fan-like plexus." [doi:10.1016/b978-0-12-369497-3.10004-4] synonym: "'fanning-out' Martinotti morphology" EXACT [] is_a: PATO:0070007 ! Martinotti morphology property_value: terms:contributor https://orcid.org/0000-0001-7258-9596 [Term] id: PATO:0070010 name: stellate morphology namespace: quality def: "A cell morphology that inheres in neurons that have dendritic processes radiating from the cell body forming a star-like shape." [ISBN:9780123973481] xref: ILX:0111036 xref: SAO:9271919883 is_a: PATO:0070026 ! multipolar neuron morphology property_value: terms:contributor https://orcid.org/0000-0001-7258-9596 [Term] id: PATO:0070011 name: chandelier cell morphology namespace: quality def: "A cell morphology that inheres in neurons which are small and round, and make highly specialized synapses with the axon initial segments of pyramidal neurons, wrapping them with candle-shaped synaptic 'cartridges'." [doi:10.1016/b978-0-12-369497-3.10004-4] comment: Chandelier cells can be bitufted or multipolar. {xref="DOI:10.1016/B978-0-12-369497-3.10004-4"} xref: ILX:0102028 xref: ilxtr:ChandelierPhenotype xref: nifext:4 is_a: PATO:0010006 ! cell morphology property_value: terms:contributor https://orcid.org/0000-0001-7258-9596 [Term] id: PATO:0070012 name: bitufted cell morphology namespace: quality def: "A cell morphology that inheres in neurons which have two clusters of primary dendrites that originate directly and extend from opposite ends of the soma, and axons that form a plexus which spreads widely. Compared to the narrow vertical axonal projection of bipolar morphology, and the 'horse-tail' axonal cluster of double boquet cells, bitufted morphology has wide horizontal axonal spans, and branching that occur close to the soma. Their vertical projection is also less extensive and crosses mostly to neighboring layers." [doi:10.1016/b978-0-12-369497-3.10004-4, PMID:15378039, PMID:18568015] xref: ilxtr:BituftedPhenotype is_a: PATO:0070027 ! bitufted dendrite cell morphology property_value: terms:contributor https://orcid.org/0000-0001-7258-9596 [Term] id: PATO:0070013 name: spiny stellate cell morphology namespace: quality def: "A cell morphology that inheres in neurons which have spiny basal dendrites and resemble pyramidal cells but lose their apical dendrites as they mature. Their axons nearly always emerge from the descending side of the soma, but often recurve and ascend with arc-like collaterals." [doi:10.1016/b978-0-12-369497-3.10004-4] xref: ilxtr:SpinyStellatePhenotype is_a: PATO:0070026 ! multipolar neuron morphology property_value: terms:contributor https://orcid.org/0000-0001-7258-9596 [Term] id: PATO:0070015 name: pyramidal family morphology namespace: quality def: "A cell morphology that inheres in neurons which have a pyramidal shaped soma, a single axon, a large apical dendrite and multiple basal dendrites." [doi:10.1016/b978-0-12-369497-3.10004-4] xref: ILX:0109553 xref: SAO:1465673360 is_a: PATO:0070026 ! multipolar neuron morphology property_value: terms:contributor https://orcid.org/0000-0001-7258-9596 [Term] id: PATO:0070016 name: horizontal pyramidal morphology namespace: quality def: "A pyramidal family morphology that inheres in neurons which have an apical tree which is oriented parallel to the pia." [PMID:30715238] xref: ilxtr:HorizontalPyramidalPhenotype is_a: PATO:0070015 ! pyramidal family morphology disjoint_from: PATO:0070017 ! standard pyramidal morphology property_value: terms:contributor https://orcid.org/0000-0001-7258-9596 [Term] id: PATO:0070017 name: standard pyramidal morphology namespace: quality def: "A pyramidal family morphology that inheres in neurons which have a standard pyramidal shape with its apical dendrite aligned vertically." [doi:10.1016/b978-0-12-369497-3.10004-4] synonym: "pyramidal cell morphology" EXACT [] synonym: "vertical pyramidal morphology" EXACT [] xref: ilxtr:PyramidalPhenotype is_a: PATO:0070015 ! pyramidal family morphology property_value: terms:contributor https://orcid.org/0000-0001-7258-9596 [Term] id: PATO:0070018 name: tufted pyramidal morphology namespace: quality def: "A pyramidal cell morphology that inheres in neurons which have a distinct tuft formation, distal from the soma." [PMID:30715238] xref: ilxtr:TuftedPyramidalPhenotype is_a: PATO:0070017 ! standard pyramidal morphology property_value: terms:contributor https://orcid.org/0000-0001-7258-9596 [Term] id: PATO:0070019 name: untufted pyramidal morphology namespace: quality def: "A pyramidal cell morphology that inheres in neurons which lack a clear tuft formation but extend to large radial distances." [PMID:30715238] xref: ilxtr:UntuftedPyramidalPhenotype is_a: PATO:0070017 ! standard pyramidal morphology property_value: terms:contributor https://orcid.org/0000-0001-7258-9596 [Term] id: PATO:0070020 name: stellate pyramidal morphology namespace: quality def: "A pyramidal cell morphology that inheres in neurons which lack a tuft formation but extend to small radial distances forming a star-like shape." [PMID:30715238] xref: ilxtr:StarPyramidalPhenotype is_a: PATO:0070017 ! standard pyramidal morphology property_value: terms:contributor https://orcid.org/0000-0001-7258-9596 [Term] id: PATO:0070021 name: inverted pyramidal morphology namespace: quality def: "A pyramidal cell morphology that inheres in neurons which have an apical tree which is oriented towards the white matter." [PMID:30715238] xref: ilxtr:InvertedPyramidalPhenotype is_a: PATO:0070017 ! standard pyramidal morphology property_value: terms:contributor https://orcid.org/0000-0001-7258-9596 [Term] id: PATO:0070025 name: unipolar neuron morphology namespace: quality def: "A cell morphology that inheres in neurons with only one process, a neurite, that extends from the cell body. The neurite then branches to form dendritic and axonal processes." [WikipediaVersioned:Unipolar_neuron&oldid=994458581] is_a: PATO:0010006 ! cell morphology property_value: terms:contributor https://orcid.org/0000-0001-7258-9596 [Term] id: PATO:0070026 name: multipolar neuron morphology namespace: quality def: "A cell morphology that inheres in neurons which possess three or more neurites, usually a single axon and many dendrites and dendritic branches." [WikipediaVersioned:Multipolar_neuron&oldid=1022942606] xref: ILX:0107196 xref: NLX:378 is_a: PATO:0010006 ! cell morphology property_value: terms:contributor https://orcid.org/0000-0001-7258-9596 [Term] id: PATO:0070027 name: bitufted dendrite cell morphology namespace: quality def: "A cell morphology that inheres in neurons with dendrites that are bidirectional, emerging from opposite ends of the soma, with the two arbors extending in radial or tangential directions." [PMID:18568015] comment: This morphology type is distinct from bitufted cell morphology in that it refers to bitufted dendrite morphology rather than bitufted cell morphology. is_a: PATO:0010006 ! cell morphology property_value: terms:contributor https://orcid.org/0000-0001-7258-9596 [Term] id: PATO:0070028 name: extratelencephalic projecting namespace: quality def: "A neuron projection quality that is a characteristic of neurons whose soma is located in the telencephalon and that project to structures outside the telencephalon" [DOI:10.1101/2020.10.19.343129] synonym: "ET projecting" EXACT [] xref: ILX:0770101 is_a: PATO:0070033 ! neuron projection quality property_value: terms:contributor https://orcid.org/0000-0001-7258-9596 [Term] id: PATO:0070029 name: corticothalamic projecting namespace: quality def: "A neuron projection quality that is a characteristic of neurons with soma in the cerebral cortex and projections to the thalamus." [DOI:10.1101/2020.10.19.343129] synonym: "CT projecting" EXACT [] xref: ILX:0770102 is_a: PATO:0070033 ! neuron projection quality property_value: terms:contributor https://orcid.org/0000-0001-7258-9596 [Term] id: PATO:0070030 name: near projecting namespace: quality def: "A neuron projection quality that is a characteristic of neurons with projections that terminate locally rather than distantly." [DOI:10.1101/2020.10.19.343129] synonym: "NP" EXACT [] xref: ILX:0770103 is_a: PATO:0070033 ! neuron projection quality property_value: terms:contributor https://orcid.org/0000-0001-7258-9596 [Term] id: PATO:0070031 name: corticomedulla projecting namespace: quality def: "A neuron projection quality that is a characteristic of neurons that project to the medulla oblongata from other brain regions." [DOI:10.1101/2020.10.19.343129] synonym: "MY projecting" EXACT [] is_a: PATO:0070033 ! neuron projection quality property_value: terms:contributor https://orcid.org/0000-0001-7258-9596 [Term] id: PATO:0070033 name: neuron projection quality namespace: quality def: "A physical quality inhering in a neuron by virtue of the relative location of its soma and the regions to which it projects and makes synaptic contacts in." [DOI:10.1101/2020.10.19.343129] is_a: PATO:0001018 ! physical quality property_value: terms:contributor https://orcid.org/0000-0001-7258-9596 [Term] id: PATO:0070034 name: intratelencephalic projecting namespace: quality def: "A neuron projection quality that is a characteristic of neurons with both soma and projections entirely within the telencephalon." [DOI:10.1101/2020.10.19.343129] synonym: "IT projecting" EXACT [] xref: ILX:0770100 is_a: PATO:0070033 ! neuron projection quality property_value: terms:contributor https://orcid.org/0000-0001-7258-9596 [Term] id: PATO:0070044 name: anatomical structure quality namespace: quality def: "A quality of continuant that exist at the anatomical level of organisation and anything under it. This includes, but is not limited to, cells , tissues, and components." [] is_a: PATO:0001241 ! physical object quality [Term] id: PATO:0070045 name: anatomical histological quality namespace: quality def: "A quality inhering in an anotomical structure by virtue of its capacity to be stained by specific histological dyes." [] is_a: PATO:0070044 ! anatomical structure quality [Term] id: PATO:0070046 name: neutrophillic namespace: quality def: "An affinity inhering in an anatomical structure by virtue of the bearer exhibiting a molecular interaction that stains and colors, pale-pink, with Wright-Giemsa stain." [GOC:add] is_a: PATO:0070045 ! anatomical histological quality [Term] id: PATO:0070047 name: polychromatophilic namespace: quality def: "An affinity inhering in an anatomical structure by virtue of the bearer exhibiting a molecular interaction for both basic and acid stains under specific pH conditions." [GOC:add] is_a: PATO:0070045 ! anatomical histological quality [Term] id: PATO:0070060 name: quality of interaction of a substance with electromagnetic radiation namespace: quality def: "A quality of a substance on which or through which electromagnetic radiation impinges or traverses with respect to radiation. This substance quality changes the quality of the incident radiation with respect to any of: intensity, direction, scatter and wavelength." [https://orcid.org/0000-0002-5111-7263] subset: attribute_slim is_a: PATO:0002198 ! quality of a substance [Term] id: PATO:0070061 name: double bouquet morphology namespace: quality def: "A cell morphology that inheres in neurons with bitufted dendritic morphology but with the special feature of a tight fascicular axonal cylinder that resembles a 'horse tail'." [PMID:15378039] is_a: PATO:0070027 ! bitufted dendrite cell morphology [Term] id: PATO:0070062 name: bistratified dendrite cell morphology namespace: quality def: "A cell morphology that inheres in neurons with dendrites that stratify at two and only two locations." [PMID:34093409] is_a: PATO:0010006 ! cell morphology property_value: terms:contributor https://orcid.org/0000-0001-7258-9596 [Term] id: PATO:0070063 name: monostratified dendrite cell morphology namespace: quality def: "A cell morphology that inheres in neurons with dendrites that stratify at one and only one location." [PMID:34093409] is_a: PATO:0010006 ! cell morphology property_value: terms:contributor https://orcid.org/0000-0001-7258-9596 [Term] id: PR:000000001 name: protein namespace: protein def: "An amino acid chain that is canonically produced de novo by ribosome-mediated translation of a genetically-encoded mRNA, and any derivatives thereof." [PRO:DAN, PRO:WCB] comment: Note that the definition allows for experimentally-manipulated genes, and allows for artifically-produced derivatives that mimic those found naturally. Note also that the definition excludes protein complexes, which some also consider a protein. Those who wish to refer to a class representing both senses of the word are directed to PR:000064867 ("protein-containing molecular entity"). Proteins (in the sense defined here) that descended from a common ancestor can be classified into families and superfamilies composed of products of evolutionarily-related genes. The domain architecture of a protein is described by the order of its constituent domains. Proteins with the same domains in the same order are defined as homeomorphic [PRO:WCB). synonym: "native protein" NARROW [IEDB:BP] synonym: "natural protein" EXACT [PRO:DAN] is_a: BFO:0000002 is_a: PR:000018263 ! amino acid chain relationship: BFO:0000051 PR:000000001 ! has part protein relationship: RO:0002353 GO:0006412 ! output of translation [Term] id: PR:000000681 name: transient receptor potential cation channel TRPV namespace: protein def: "A transient receptor potential channel protein that is a member of the subfamily V of the transient receptor potential cation channels (TRPs), with amino- and carboxyl-terminal intracellular domains separated by a domain (common with other ion channels) containing six transmembrane helices (S1-S6) in which the last two helices (S5 and S6) flank a loop, called the pore loop, which determines ion selectivity. The amino-terminal domain contains up to 6 copies of detectable ankyrin repeat (Pfam:PF00023). Most TRPs are relatively non-selective. They may be modulated by voltage changes but channel gating is generally effected by other means." [PMID:16382100, PMID:16460286, PMID:17579562, PRO:WCB] comment: Category=family. synonym: "fam:TRPV" EXACT PRO-short-label [PRO:DAN] xref: PIRSF:PIRSF038527 is_a: PR:000044657 ! transient receptor potential channel protein [Term] id: PR:000001002 name: CD19 molecule namespace: protein def: "A protein that is a translation product of the human CD19 gene or a 1:1 ortholog thereof. It is composed of an N-terminal extracellular domain containing two Ig-like C2-type (immunoglobulin-like) domains, followed by a single-pass transmembrane segment and a cytoplasmic C-terminal tail. CD19 expression is restricted to members of the B cell lineage. It functions as a co-receptor for B-cell antigen receptor (BCR), regulating signal transduction." [PMID:15778510] comment: Category=gene. Requested by=CL. synonym: "B-lymphocyte surface antigen B4" EXACT [] synonym: "CD19" EXACT PRO-short-label [PRO:DNx] synonym: "differentiation antigen CD19" EXACT [] synonym: "T-cell surface antigen Leu-12" EXACT [] xref: IUPHARobj:2764 xref: PIRSF:PIRSF016630 is_a: PR:000000001 ! protein [Term] id: PR:000001003 name: CD34 molecule namespace: protein def: "A protein that is a translation product of the human CD34 gene or a 1:1 ortholog thereof. It is a leukocyte membrane protein expressed specifically by lymphohematopoietic progenitor cells. It contains a single-pass transmembrane domain and that show distinct expression on early hematopoietic precursors and vascular-associated tissue. Acts as a scaffold that presents selectin carbohydrate ligands in a clustered, tissue specific manner to allow for higher avidity interactions between leukocytes and endothelial cells during the inflammatory process. In common with related sialomucins (endoglycan and podocalyxin), the extracellular region is dominated by an N-terminal mucin-like domain, which is densely substituted with sialylated O-linked carbohydrates. The mucin-like region is followed by a cysteine-containing and presumably globular domain. This domain may fold into an immunoglobulin-like structure as the positions of 2 of the cysteines are conserved in the C2 set of the immunoglobulin superfamily. The cytoplasmic domain is around 73-76 residues long and highly conserved." [PMID:16720896, PMID:8983065] comment: Category=gene. Requested by=CL. synonym: "CD34" EXACT PRO-short-label [PRO:DNx] synonym: "hematopoietic progenitor cell antigen CD34" EXACT [] xref: PIRSF:PIRSF028749 is_a: PR:000000001 ! protein [Term] id: PR:000001004 name: CD4 molecule namespace: protein def: "A protein that is a translation product of the human CD4 gene or a 1:1 ortholog thereof. CD4 is an accessory protein for MHC class-II antigen/T-cell receptor interaction. It is the primary receptor for HIV-1. CD4 has four immunoglobulin-like domains in its extracellular region that share the same structure, but can differ in sequence." [PMID:15326605] comment: Category=gene. Requested by=CL. synonym: "CD4" EXACT PRO-short-label [PRO:DNx] synonym: "T-cell differentiation antigen L3T4" EXACT [] synonym: "T-cell surface antigen T4/Leu-3" EXACT [] synonym: "T-cell surface glycoprotein CD4" EXACT [] xref: PIRSF:PIRSF001977 is_a: PR:000000001 ! protein [Term] id: PR:000001005 name: integrin alpha with A domain namespace: protein def: "An integrin alpha that contains an A domain. A hallmark of this class is the presence of a von Willebrand factor type A domain (Pfam:PF00092) (I-domain) of approximately 200 amino acid residues at the N terminus, which confers divalent cation binding properties. Unlike other integrin alpha proteins, they do not undergo proteolytic cleavage." [PIRSF:PIRSF002497] comment: Category=family. synonym: "integrin alpha with I domain" EXACT [] xref: PIRSF:PIRSF002497 is_a: PR:000025796 ! integrin alpha [Term] id: PR:000001006 name: receptor-type tyrosine-protein phosphatase C namespace: protein def: "A protein that is a translation product of the human PTPRC gene or a 1:1 ortholog thereof. It is composed of an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic protein-tyrosine phosphatase domains. Contains 1 to 3 copies of the Fibronectin type III domain (Pfam:PF00041) followed by two copies of the Protein-tyrosine phosphatase (Pfam:PF00102) domain. Receptor-type tyrosine-protein phosphatase C (CD45) regulates signal transduction and lymphocyte activation by specific association with receptor molecules on T and B cells. Multiple isoforms of CD45 (180-235 kDa) can be generated asa result of alternative splicing of three variable exons 4(A), 5(B) and 6(C), encoding sequences at the N-terminal extracellular domain of the molecule." [PMID:1351092, PRO:CNA] comment: Category=gene. Requested by=CL. synonym: "CD45" RELATED Gene-based [] synonym: "L-CA" EXACT [] synonym: "leukocyte common antigen" EXACT [] synonym: "ly-5" EXACT [] synonym: "lymphocyte antigen 5" EXACT [] synonym: "PTPRC" EXACT PRO-short-label [PRO:DNx] synonym: "T200" BROAD [PRO:DNx] xref: IUPHARobj:1852 xref: PIRSF:PIRSF002004 is_a: PR:000000001 ! protein [Term] id: PR:000001007 name: integrin alpha-1 namespace: protein def: "An integrin alpha with A domain that is a translation product of the human ITGA1 gene or a 1:1 ortholog thereof." [PRO:CNA] comment: Category=gene. synonym: "CD49 antigen-like family member A" EXACT [] synonym: "CD49a" EXACT [] synonym: "ITGA1" EXACT PRO-short-label [PRO:DNx] synonym: "laminin and collagen receptor" EXACT [] synonym: "VLA-1" EXACT [] xref: IUPHARobj:2437 is_a: PR:000001005 ! integrin alpha with A domain [Term] id: PR:000001008 name: integrin alpha-2 namespace: protein def: "An integrin alpha with A domain that is a translation product of the human ITGA2 gene or a 1:1 ortholog thereof." [PRO:CNA] comment: Category=gene. Requested by=CL. synonym: "CD49 antigen-like family member B" EXACT [] synonym: "CD49B" RELATED Gene-based [] synonym: "CD49b" EXACT [] synonym: "collagen receptor" EXACT [] synonym: "GPIa" EXACT [] synonym: "ITGA2" EXACT PRO-short-label [PRO:DNx] synonym: "platelet membrane glycoprotein Ia" EXACT [] synonym: "VLA-2 subunit alpha" EXACT [] xref: IUPHARobj:2440 is_a: PR:000001005 ! integrin alpha with A domain [Term] id: PR:000001010 name: integrin alpha-E namespace: protein def: "An integrin alpha with A domain that is a translation product of the human ITGAE gene or a 1:1 ortholog thereof." [PRO:CNA] comment: Category=gene. Requested by=CL. synonym: "CD103" EXACT [] synonym: "HML-1 antigen" EXACT [] synonym: "integrin alpha M290" EXACT [] synonym: "integrin alpha-IEL" EXACT [] synonym: "ITGAE" EXACT PRO-short-label [PRO:DNx] synonym: "mucosal lymphocyte 1 antigen" EXACT [] xref: IUPHARobj:2450 is_a: PR:000001005 ! integrin alpha with A domain [Term] id: PR:000001012 name: integrin alpha-M namespace: protein def: "An integrin alpha with A domain that is a translation product of the human ITGAM gene or a 1:1 ortholog thereof. They constitute subunits of the integrin alpha-M/beta-2 receptor. This receptor is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles. It is also a receptor for fibrinogen, factor X and ICAM1." [UniProtKB:P11215] comment: Category=gene. Requested by=CL. synonym: "CD11 antigen-like family member B" EXACT [] synonym: "CD11B" RELATED Gene-based [] synonym: "CD11b" EXACT [] synonym: "cell surface glycoprotein MAC-1 subunit alpha" EXACT [] synonym: "CR-3 alpha chain" EXACT [] synonym: "CR3A" RELATED Gene-based [] synonym: "ITGAM" EXACT PRO-short-label [PRO:DNx] synonym: "leukocyte adhesion receptor MO1" EXACT [] synonym: "neutrophil adherence receptor" EXACT [] xref: IUPHARobj:2452 is_a: PR:000001005 ! integrin alpha with A domain [Term] id: PR:000001013 name: integrin alpha-X namespace: protein def: "An integrin alpha with A domain that is a translation product of the human ITGAX gene or a 1:1 ortholog thereof. Integrin alpha-X complexed with beta-2 is a receptor for fibrinogen. It recognizes the sequence GPR in fibrinogen. It mediates cell-cell interaction during inflammatory responses. It is especially important in monocyte adhesion and chemotaxis." [UniProtKB:P20702] comment: Category=gene. Requested by=CL. synonym: "CD11 antigen-like family member C" EXACT [] synonym: "CD11C" RELATED Gene-based [] synonym: "CD11c" EXACT [] synonym: "ITGAX" EXACT PRO-short-label [PRO:DNx] synonym: "Leu M5" EXACT [] synonym: "leukocyte adhesion glycoprotein p150,95 alpha chain" EXACT [] synonym: "leukocyte adhesion receptor p150,95" EXACT [] xref: IUPHARobj:2454 is_a: PR:000001005 ! integrin alpha with A domain [Term] id: PR:000001014 name: receptor-type tyrosine-protein phosphatase C isoform CD45RABC namespace: protein def: "A receptor-type tyrosine-protein phosphatase C that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P08575-3 or a 1:1 ortholog thereof." [PMID:1351092, PRO:CNA, PRO:DAN] comment: Category=sequence. Requested by=CL. Note: This isoform includes the region encoded by the variable exons 4(A), 5(B), and 6(C). synonym: "B220" RELATED [] synonym: "CD45R" RELATED [] synonym: "CD45RABC" EXACT [] synonym: "PTPRC/iso:CD45RABC" EXACT PRO-short-label [PRO:DNx] is_a: PR:000001006 ! receptor-type tyrosine-protein phosphatase C [Term] id: PR:000001015 name: receptor-type tyrosine-protein phosphatase C isoform CD45RA namespace: protein def: "A receptor-type tyrosine-protein phosphatase C isoform CD45R that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P08575-8 or a 1:1 ortholog thereof." [PMID:1351092, PRO:CNA, PRO:DAN] comment: Category=sequence. Requested by=CL. Note: This isoform includes the region encoded by the variable exon 4(A), and lacks the region encoded by exons 5(B) and 6(C). synonym: "CD45RA" EXACT [] synonym: "PTPRC/iso:CD45RA" EXACT PRO-short-label [PRO:DNx] is_a: PR:000050216 ! receptor-type tyrosine-protein phosphatase C isoform CD45R [Term] id: PR:000001017 name: receptor-type tyrosine-protein phosphatase C isoform CD45RO namespace: protein def: "A receptor-type tyrosine-protein phosphatase C that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P08575-4 or a 1:1 ortholog thereof." [PMID:1351092, PRO:CNA, PRO:DAN] comment: Category=sequence. Requested by=CL. Note: This isoform lacks the region encoded by the variable exons 4(A), 5(B), and 6(C). synonym: "180 kDa form" EXACT [] synonym: "CD45RO" EXACT [GOC:add, PRO:ADD] synonym: "PTPRC/iso:CD45RO" EXACT PRO-short-label [PRO:DNx] synonym: "T200" RELATED [] is_a: PR:000001006 ! receptor-type tyrosine-protein phosphatase C [Term] id: PR:000001018 name: CD3 subunit with immunoglobulin domain namespace: protein def: "A protein that has a core domain composition consisting of an extracellular N-terminal domain that adopts an immunoglobulin fold, a transmembrane domain, and an intracellular C-terminal domain with a single copy of the Immunoreceptor tyrosine-based activation motif (Pfam:PF02189) (ITAM). It constitutes the invariant subunit of the T cell antigen receptor (TCR). TCR is a surface receptor on T cells responsible for recognizing MHC-restricted antigens and initiating the cellular immune response." [PMID:16473826, PMID:1724736] comment: Category=family. synonym: "CD3 subunit with Ig-like domain" EXACT [] xref: PIRSF:PIRSF001993 is_a: PR:000000001 ! protein [Term] id: PR:000001020 name: CD3 epsilon namespace: protein def: "A CD3 subunit with immunoglobulin domain that is a translation product of the human CD3E gene or a 1:1 ortholog thereof." [PRO:CNA] comment: Category=gene. Requested by=CL. synonym: "CD3E" EXACT PRO-short-label [PRO:DNx] synonym: "CD3e" EXACT [] synonym: "T-cell surface antigen T3/Leu-4 epsilon chain" EXACT [] synonym: "T3E" RELATED Gene-based [] xref: IUPHARobj:2742 is_a: PR:000001018 ! CD3 subunit with immunoglobulin domain [Term] id: PR:000001022 name: neural cell adhesion molecule namespace: protein def: "A protein with a domain composition consisting of a large extracellular domain, including five Ig-like C2-type domains followed by two copies of the Fibronectin type-III domain (Pfam:PF00041), a single-pass transmembrane domain and a short cytoplasmic C-terminal domain." [PRO:CNA] comment: Category=family. xref: PIRSF:PIRSF002507 is_a: PR:000000001 ! protein [Term] id: PR:000001023 name: neural cell adhesion molecule NCAM namespace: protein def: "A neural cell adhesion molecule that is involved in neuronal development, synaptic plasticity, and regeneration." [PMID:17975827] comment: Category=family. xref: PIRSF:PIRSF501037 is_a: PR:000001022 ! neural cell adhesion molecule [Term] id: PR:000001024 name: neural cell adhesion molecule 1 namespace: protein def: "A neural cell adhesion molecule NCAM that is a translation product of the human NCAM1 gene or a 1:1 ortholog thereof." [PRO:CNA] comment: Category=gene. Requested by=CL. synonym: "CD56" EXACT [] synonym: "N-CAM-1" EXACT [] synonym: "NCAM" RELATED Gene-based [] synonym: "NCAM-1" EXACT [] synonym: "NCAM1" EXACT PRO-short-label [PRO:DNx] xref: IUPHARobj:2769 is_a: PR:000001023 ! neural cell adhesion molecule NCAM [Term] id: PR:000001025 name: C-type lectin with multiple lectin domains namespace: protein def: "A protein that is a type I transmembrane receptor with an N-terminal cysteine-rich domain, a single Fibronectin type II (FNII) domain (Pfam:PF00040) and eight to ten copies of the Lectin C-type domain (Pfam:PF00059) (CTLDs). The presence of multiple copies of the CTLD domain is a hallmark of this class." [PMID:12223280] comment: Category=family. xref: PIRSF:PIRSF002427 is_a: PR:000000001 ! protein [Term] id: PR:000001026 name: lymphocyte antigen 75 namespace: protein def: "A C-type lectin with multiple lectin domains that is a translation product of the mouse LY75 gene or a 1:1 ortholog thereof. It consists of 12 extracellular domains (an N-terminal cysteine-rich domain, a fibronectin type II domain and 10 C-type carbohydrate recognition domains), a transmembrane region and a small cytoplasmic C terminus containing a single Tyr residue, but no obvious kinase domain." [PMID:9862343] comment: Category=gene. Requested by=CL. Note: Acts as an endocytic receptor to direct captured antigens from the extracellular space to a specialized antigen-processing compartment. synonym: "C-type lectin domain family 13 member B" EXACT [] synonym: "CD205" EXACT [] synonym: "CLEC13B" RELATED [] synonym: "DEC-205" EXACT [] synonym: "gp200-MR6" EXACT [] synonym: "ly-75" EXACT [] synonym: "LY75" EXACT PRO-short-label [PRO:DNx] is_a: PR:000001025 ! C-type lectin with multiple lectin domains [Term] id: PR:000001064 name: transient receptor potential cation channel TRPV2 namespace: protein def: "A transient receptor potential cation channel TRPV that is a translation product of the human TRPV2 gene or a 1:1 ortholog thereof." [PRO:CNA] comment: Category=gene. synonym: "GRC" EXACT [] synonym: "growth factor-regulated calcium channel" EXACT [] synonym: "Osm-9-like TRP channel 2" EXACT [] synonym: "OTRPC2" EXACT [] synonym: "TRPV2" EXACT PRO-short-label [PRO:DNx] synonym: "TrpV2" EXACT [] synonym: "vanilloid receptor-like protein 1" EXACT [] synonym: "VRL" RELATED Gene-based [] synonym: "VRL-1" EXACT [] xref: IUPHARobj:508 is_a: PR:000000681 ! transient receptor potential cation channel TRPV [Term] id: PR:000001065 name: transient receptor potential cation channel TRPV1 namespace: protein def: "A transient receptor potential cation channel TRPV that is a translation product of the human TRPV1 gene or a 1:1 ortholog thereof." [PRO:CNA] comment: Category=gene. synonym: "capsaicin receptor" EXACT [] synonym: "Osm-9-like TRP channel 1" EXACT [] synonym: "OTRPC1" EXACT [] synonym: "TRPV1" EXACT PRO-short-label [PRO:DNx] synonym: "TrpV1" EXACT [] synonym: "vanilloid receptor 1" EXACT [] synonym: "VR1" RELATED Gene-based [] xref: IUPHARobj:507 is_a: PR:000000681 ! transient receptor potential cation channel TRPV [Term] id: PR:000001082 name: CD160 molecule namespace: protein def: "A protein that is a translation product of the human CD160 gene or a 1:1 ortholog thereof." [PRO:CNA] comment: Category=gene. synonym: "BY55" RELATED Gene-based [] synonym: "CD160" EXACT PRO-short-label [PRO:DNx] synonym: "CD160 antigen" EXACT [] synonym: "natural killer cell receptor BY55" EXACT [] xref: PIRSF:PIRSF038702 is_a: PR:000000001 ! protein [Term] id: PR:000001083 name: CD2 molecule namespace: protein def: "A protein that is a translation product of the human CD2 gene or a 1:1 ortholog thereof." [PRO:CNA] comment: Category=gene. Requested by=CL. synonym: "CD2" EXACT PRO-short-label [PRO:DNx] synonym: "erythrocyte receptor" EXACT [] synonym: "LFA-2" EXACT [] synonym: "LFA-3 receptor" EXACT [] synonym: "ly-37" EXACT [] synonym: "lymphocyte antigen 37" EXACT [] synonym: "rosette receptor" EXACT [] synonym: "SRBC" RELATED Gene-based [] synonym: "T-cell surface antigen CD2" EXACT [] synonym: "T-cell surface antigen T11/Leu-5" EXACT [] synonym: "T-cell surface glycoprotein CD2" EXACT [] xref: IUPHARobj:2600 xref: PIRSF:PIRSF001984 is_a: PR:000000001 ! protein [Term] id: PR:000001084 name: T-cell surface glycoprotein CD8 alpha chain namespace: protein def: "A protein that is a translation product of the human CD8A gene or a 1:1 ortholog thereof. CD8 is a transmembrane that is a co-receptor for MHC class-I antigen/T-cell receptor interaction. The most common form of CD8 is composed of a CD8 alpha and a CD8 beta chain." [PMID:11114424, PRO:CNA, Wikipedia:CD8] comment: Category=gene. Requested by=CL. synonym: "CD8A" EXACT PRO-short-label [PRO:DNx] synonym: "CD8a" EXACT [] synonym: "Lyt-2" RELATED Gene-based [] synonym: "Lyt2" RELATED Gene-based [] synonym: "MAL" RELATED Gene-based [] synonym: "T-cell surface glycoprotein Lyt-2" EXACT [] synonym: "T-lymphocyte differentiation antigen T8/Leu-2" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000001085 name: T-cell surface glycoprotein CD8 beta chain namespace: protein def: "A protein that is a translation product of the human CD8B gene or a 1:1 ortholog thereof. CD8 is a transmembrane receptor that is a co-receptor for MHC class-I antigen/T-cell receptor interaction. The most common form of CD8 is composed of a CD8 alpha and a CD8 beta chain." [PRO:CNA, Wikipedia:CD8] comment: Category=gene. synonym: "CD8B" EXACT PRO-short-label [PRO:DNx] synonym: "CD8B1" RELATED Gene-based [] synonym: "Ly-3" RELATED Gene-based [] synonym: "lymphocyte antigen 3" EXACT [] synonym: "Lyt-3" RELATED Gene-based [] synonym: "Lyt3" RELATED Gene-based [] synonym: "T-cell membrane glycoprotein Ly-3" EXACT [] synonym: "T-cell surface glycoprotein Lyt-3" EXACT [] xref: PIRSF:PIRSF002020 is_a: PR:000000001 ! protein [Term] id: PR:000001087 name: adhesion G-protein coupled receptor namespace: protein def: "A G-protein coupled receptor with a 7 transmembrane (secretin family) domain (Pfam:PF00002) preceded by an amino-terminal region containing one or more functional domains with adhesion-like motifs." [PMID:12761335, PRO:DAN, PRO:WCB] comment: Category=family. Classification based on GRAFS system. [PMID:12761335] synonym: "adhesion class GPCR" EXACT [IUPHARfam:17] synonym: "fam:adhesion" EXACT PRO-short-label [PRO:DAN] synonym: "secretin receptor-like G-protein coupled receptor" RELATED [] synonym: "subfamily B2 G-protein coupled receptor" EXACT [PMID:11790261] xref: IUPHAR:GPCRListForward?class=adhesion xref: IUPHARfam:17 is_a: PR:000030035 ! G-protein coupled receptor [Term] id: PR:000001094 name: rhodopsin-like G-protein coupled receptor namespace: protein def: "A G-protein coupled receptor that contains the 7 transmembrane receptor (rhodopsin family) domain (Pfam:PF00001), which includes 7 transmembrane helices (TMI-TM7) with 3 intracellular loops (IL1-IL3) and 3 extracellular loops (EL1-EL3) between the helices. The amino-terminal region is extracellular and the carboxyl-terminal region is intracellular. Rhodopsin-like G-protein coupled receptors (GPCRs) are unique among the several classes of GPCRs in that most have a very short amino-terminal segment and several characteristic sequence motifs, particularly NSxxNPxxY in TM7 and D/E-R-Y/F between TM3 and loop IL2. Most bind their ligands within a cavity between the TM regions." [PMID:12761335, PRO:DAN, PRO:WCB] comment: Category=family. Classification based on GRAFS system. [PMID:12761335] synonym: "class 1 G-protein coupled receptor" EXACT [PMID:15914470] synonym: "class A G-protein coupled receptor" EXACT [IUPHAR:GPCRListForward?class=A] synonym: "fam:rhodopsin" EXACT PRO-short-label [PRO:DAN] xref: IUPHAR:GPCRListForward?class=A xref: PIRSF:PIRSF800006 is_a: PR:000030035 ! G-protein coupled receptor [Term] id: PR:000001107 name: D(1)-like dopamine receptor namespace: protein def: "A dopamine receptor that is a product of the DRD1 or DRD5 gene. The active form binds dopamine and its activity is mediated by G proteins that cause activation of adenylate cyclase." [PRO:WCB, Wikipedia:Dopamine_receptor] comment: Category=family. xref: PIRSF:PIRSF038629 is_a: PR:000044633 ! dopamine receptor [Term] id: PR:000001108 name: D(2)-like dopamine receptor namespace: protein def: "A dopamine receptor that is a product of the DRD2, DRD3, or DRD4 gene. The active form binds dopamine and its activity is mediated by G proteins that cause inhibition of adenylate cyclase." [PRO:WCB, Wikipedia:Dopamine_receptor] comment: Category=family. xref: PIRSF:PIRSF038553 is_a: PR:000044633 ! dopamine receptor [Term] id: PR:000001119 name: animal opsin namespace: protein def: "A rhodopsin-like G-protein coupled receptor that is a translation product of the human OPN1LW, OPN1MW, OPN1SW, RHO, OPN3, OPN4, or OPN5 genes, 1:1 orthologs thereof, or a semi-ortholog thereof in Metazoa. The active form binds a vitamin A-based retinaldehyde chromophore through a Schiff base linkage to a Lys residue in the seventh transmembrane alpha helix." [PRO:WCB, PRO:XQ, Wikipedia:Opsin] comment: Category=family. synonym: "opsin receptor" EXACT [IUPHARfam:975] synonym: "type II opsin" EXACT [Wikipedia:Opsin] xref: IUPHARfam:975 xref: PIRSF:PIRSF038544 is_a: PR:000001094 ! rhodopsin-like G-protein coupled receptor is_a: PR:000036194 ! eukaryotic protein relationship: RO:0002160 NCBITaxon:33208 ! only in taxon Metazoa [Term] id: PR:000001128 name: chemokine receptor namespace: protein def: "A rhodopsin-like G-protein coupled receptor that in active form binds to one or more chemokines." [PMID:12037138, PRO:WCB, PRO:XQ] comment: Category=family. Note: Only those that have been unequivocally shown to activate a G-protein coupled signaling pathway appear on the official IUPHAR list. xref: IUPHARfam:14 xref: PIRSF:PIRSF038545 is_a: PR:000001094 ! rhodopsin-like G-protein coupled receptor [Term] id: PR:000001175 name: D(1A) dopamine receptor namespace: protein def: "A D(1)-like dopamine receptor that is a translation product of the human DRD1 gene or a 1:1 ortholog thereof." [PRO:WCB] comment: Category=gene. synonym: "dopamine D1 receptor" EXACT [] synonym: "DRD1" EXACT PRO-short-label [PRO:DNx] synonym: "Drd1a" RELATED Gene-based [] synonym: "Gpcr15" RELATED Gene-based [] xref: IUPHARobj:214 is_a: PR:000001107 ! D(1)-like dopamine receptor [Term] id: PR:000001177 name: D(2) dopamine receptor namespace: protein def: "A D(2)-like dopamine receptor that is a translation product of the human DRD2 gene or a 1:1 ortholog thereof." [PRO:WCB] comment: Category=gene. synonym: "dopamine D2 receptor" EXACT [] synonym: "DRD2" EXACT PRO-short-label [PRO:DNx] xref: IUPHARobj:215 is_a: PR:000001108 ! D(2)-like dopamine receptor [Term] id: PR:000001197 name: chemokine receptor CCR1/3/1L namespace: protein def: "A chemokine receptor that is a translation product of the human CCR1 or CCR3 genes, the mouse CCR1L1 gene, 1:1 orthologs thereof, or a semi-ortholog thereof." [PRO:DAN, PRO:WCB] comment: Category=family. xref: PIRSF:PIRSF501024 is_a: PR:000001128 ! chemokine receptor [Term] id: PR:000001199 name: C-C chemokine receptor type 2 namespace: protein def: "A chemokine receptor that is a translation product of the human CCR2 gene or a 1:1 ortholog thereof. The preferred ligands include CCL2, CCL7, CCL8, CCL13." [PMID:12037138, PRO:WCB] comment: Category=gene. Requested by=CL. synonym: "C-C CKR-2" EXACT [] synonym: "CC-CKR-2" EXACT [] synonym: "CCR-2" EXACT [] synonym: "CCR2" EXACT PRO-short-label [PRO:DNx] synonym: "CD192" EXACT [] synonym: "chemokine receptor CCR2" EXACT [] synonym: "CMKBR2" RELATED Gene-based [] synonym: "JE/FIC receptor" EXACT [] synonym: "MCP-1 receptor" EXACT [] synonym: "MCP-1-R" EXACT [] synonym: "monocyte chemoattractant protein 1 receptor" EXACT [] xref: IUPHARobj:59 is_a: PR:000001128 ! chemokine receptor [Term] id: PR:000001200 name: C-C chemokine receptor type 4 namespace: protein def: "A chemokine receptor that is a translation product of the human CCR4 gene or a 1:1 ortholog thereof. The preferred ligands include CCL17 and CCL22." [PMID:12037138, PRO:WCB] comment: Category=gene. synonym: "C-C CKR-4" EXACT [] synonym: "CC-CKR-4" EXACT [] synonym: "CCR-4" EXACT [] synonym: "CCR4" EXACT PRO-short-label [PRO:DNx] synonym: "CD194" EXACT [] synonym: "chemokine receptor CCR4" EXACT [] synonym: "CMKBR4" RELATED Gene-based [] synonym: "K5-5" EXACT [] xref: IUPHARobj:61 is_a: PR:000001128 ! chemokine receptor [Term] id: PR:000001201 name: C-C chemokine receptor type 5 namespace: protein def: "A chemokine receptor that is a translation product of the human CCR5 gene or a 1:1 ortholog thereof. The preferred ligands include CCL3, CCL4, CCL5, CCL8, CCL14." [PMID:12037138, PRO:WCB] comment: Category=gene. Requested by=CL. synonym: "C-C CKR-5" EXACT [] synonym: "CC-CKR-5" EXACT [] synonym: "CCR-5" EXACT [] synonym: "CCR5" EXACT PRO-short-label [PRO:DNx] synonym: "CD195" EXACT [] synonym: "chemokine receptor CCR5" EXACT [] synonym: "CHEMR13" EXACT [] synonym: "CMKBR5" RELATED Gene-based [] synonym: "HIV-1 fusion coreceptor" EXACT [] synonym: "MIP-1 alpha receptor" EXACT [] xref: IUPHARobj:62 is_a: PR:000001128 ! chemokine receptor [Term] id: PR:000001202 name: C-C chemokine receptor type 6 namespace: protein def: "A chemokine receptor that is a translation product of the human CCR6 gene or a 1:1 ortholog thereof. The preferred ligand is CCL20." [PMID:12037138, PRO:WCB] comment: Category=gene. Requested by=CL. synonym: "C-C CKR-6" EXACT [] synonym: "CC-CKR-6" EXACT [] synonym: "CCR-6" EXACT [] synonym: "CCR6" EXACT PRO-short-label [PRO:DNx] synonym: "CD196" EXACT [] synonym: "chemokine receptor CCR6" EXACT [] synonym: "chemokine receptor-like 3" EXACT [] synonym: "CKR-L3" EXACT [] synonym: "CKRL3" RELATED Gene-based [] synonym: "CMKBR6" RELATED Gene-based [] synonym: "DRY6" EXACT [] synonym: "G-protein coupled receptor 29" EXACT [] synonym: "GPR-CY4" EXACT [] synonym: "GPR29" RELATED Gene-based [] synonym: "GPRCY4" EXACT [] synonym: "KY411" EXACT [] synonym: "LARC receptor" EXACT [] synonym: "STRL22" RELATED Gene-based [] xref: IUPHARobj:63 is_a: PR:000001128 ! chemokine receptor [Term] id: PR:000001203 name: C-C chemokine receptor type 7 namespace: protein def: "A chemokine receptor that is a translation product of the human CCR7 gene or a 1:1 ortholog thereof. The preferred ligands are CCL19 and CCL21." [PMID:12037138, PRO:WCB] comment: Category=gene. Requested by=CL. synonym: "BLR2" EXACT [] synonym: "C-C CKR-7" EXACT [] synonym: "CC-CKR-7" EXACT [] synonym: "CCR-7" EXACT [] synonym: "CCR7" EXACT PRO-short-label [PRO:DNx] synonym: "CD197" EXACT [] synonym: "CDw197" EXACT [] synonym: "chemokine receptor CCR7" EXACT [] synonym: "CMKBR7" RELATED Gene-based [] synonym: "EBI1" RELATED Gene-based [] synonym: "Ebi1h" RELATED Gene-based [] synonym: "EBV-induced G-protein coupled receptor 1" EXACT [] synonym: "epstein-Barr virus-induced G-protein coupled receptor 1" EXACT [] synonym: "EVI1" RELATED Gene-based [] synonym: "MIP-3 beta receptor" EXACT [] xref: IUPHARobj:64 is_a: PR:000001128 ! chemokine receptor [Term] id: PR:000001206 name: CX3C chemokine receptor 1 namespace: protein def: "A chemokine receptor that is a translation product of the human CX3CR1 gene or a 1:1 ortholog thereof. The preferred ligand is CX3CL1." [PMID:12037138, PRO:WCB] comment: Category=gene. Requested by=CL. synonym: "beta chemokine receptor-like 1" EXACT [] synonym: "C-X3-C CKR-1" EXACT [] synonym: "chemokine receptor CX3CR1" EXACT [] synonym: "CMK-BRL-1" EXACT [] synonym: "CMK-BRL1" EXACT [] synonym: "CMKBRL1" RELATED Gene-based [] synonym: "CX3CR1" EXACT PRO-short-label [PRO:DNx] synonym: "fractalkine receptor" EXACT [] synonym: "G-protein coupled receptor 13" EXACT [] synonym: "GPR13" RELATED Gene-based [] synonym: "V28" EXACT [] xref: IUPHARobj:74 xref: PIRSF:PIRSF501025 is_a: PR:000001128 ! chemokine receptor [Term] id: PR:000001207 name: C-X-C chemokine receptor type 3 namespace: protein def: "A chemokine receptor that is a translation product of the human CXCR3 gene or a 1:1 ortholog thereof. The preferred ligands include CXCL9, CXCL10, CXCL11." [PMID:12037138, PRO:WCB] comment: Category=gene. synonym: "CD183" EXACT [] synonym: "chemokine receptor CXCR3" EXACT [] synonym: "CKR-L2" EXACT [] synonym: "Cmkar3" RELATED Gene-based [] synonym: "CXC-R3" EXACT [] synonym: "CXCR-3" EXACT [] synonym: "CXCR3" EXACT PRO-short-label [PRO:DNx] synonym: "G-protein coupled receptor 9" EXACT [] synonym: "GPR9" RELATED Gene-based [] synonym: "interferon-inducible protein 10 receptor" EXACT [] synonym: "IP-10 receptor" EXACT [] xref: IUPHARobj:70 xref: PIRSF:PIRSF501023 is_a: PR:000001128 ! chemokine receptor [Term] id: PR:000001208 name: C-X-C chemokine receptor type 4 namespace: protein def: "A chemokine receptor that is a translation product of the human CXCR4 gene or a 1:1 ortholog thereof. The preferred ligand is CXCL12." [PMID:12037138, PRO:WCB] comment: Category=gene. Requested by=CL. synonym: "CD184" EXACT [] synonym: "chemokine receptor CXCR4" EXACT [] synonym: "Cmkar4" RELATED Gene-based [] synonym: "CXC-R4" EXACT [] synonym: "CXCR-4" EXACT [] synonym: "CXCR4" EXACT PRO-short-label [PRO:DNx] synonym: "FB22" EXACT [] synonym: "fusin" EXACT [] synonym: "HM89" EXACT [] synonym: "LCR1" EXACT [] synonym: "LESTR" EXACT [] synonym: "leukocyte-derived seven transmembrane domain receptor" EXACT [] synonym: "NPYRL" EXACT [] synonym: "PB-CKR" EXACT [] synonym: "pre-B-cell-derived chemokine receptor" EXACT [] synonym: "SDF-1 receptor" EXACT [] synonym: "Sdf1r" RELATED Gene-based [] synonym: "stromal cell-derived factor 1 receptor" EXACT [] xref: IUPHARobj:71 xref: PIRSF:PIRSF501021 is_a: PR:000001128 ! chemokine receptor [Term] id: PR:000001209 name: C-X-C chemokine receptor type 5 namespace: protein def: "A chemokine receptor that is a translation product of the human CXCR5 gene or a 1:1 ortholog thereof. The preferred ligand is CXCL13." [PMID:12037138, PRO:WCB] comment: Category=gene. Requested by=CL. synonym: "BLR1" RELATED Gene-based [] synonym: "burkitt lymphoma receptor 1" EXACT [] synonym: "burkitt lymphoma receptor 1 homolog" EXACT [] synonym: "CD185" EXACT [] synonym: "chemokine receptor CXCR5" EXACT [] synonym: "CXC-R5" EXACT [] synonym: "CXCR-5" EXACT [] synonym: "CXCR5" EXACT PRO-short-label [PRO:DNx] synonym: "Gpcr6" RELATED Gene-based [] synonym: "MDR-15" EXACT [] synonym: "MDR15" RELATED Gene-based [] synonym: "monocyte-derived receptor 15" EXACT [] xref: IUPHARobj:72 is_a: PR:000001128 ! chemokine receptor [Term] id: PR:000001224 name: medium-wave-sensitive opsin namespace: protein def: "An animal opsin that is a translation product of the human OPN1MW, OPN1MW2, or OPN1MW3 genes, 1:1 orthologs thereof, or a semi-ortholog thereof." [PRO:DAN, PRO:WCB] comment: Category=gene. Note: The human OPN1MW, OPN1MW2, and OPN1MW3 genes encode identical proteins. synonym: "Gcp" RELATED [] synonym: "GOP" EXACT [] synonym: "green cone photoreceptor pigment" EXACT [] synonym: "green-sensitive opsin" EXACT [] synonym: "M opsin" EXACT [] synonym: "medium wavelength-sensitive cone opsin" EXACT [] synonym: "OPN1MW" EXACT PRO-short-label [PRO:DNx] synonym: "Opn1mw" RELATED [] synonym: "OPN1MW2" RELATED [] xref: IUPHARobj:2962 is_a: PR:000001119 ! animal opsin [Term] id: PR:000001226 name: high affinity interleukin-8 receptor namespace: protein def: "A chemokine receptor whose active form binds interleukin-8 with high affinity." [PRO:WCB] comment: Category=family. xref: PIRSF:PIRSF501022 is_a: PR:000001128 ! chemokine receptor [Term] id: PR:000001243 name: melanopsin namespace: protein def: "An animal opsin that is a translation product of the human OPN4 gene or a 1:1 ortholog thereof." [PRO:WCB] comment: Category=gene. synonym: "MOP" RELATED Gene-based [] synonym: "Mopn" RELATED Gene-based [] synonym: "OPN4" EXACT PRO-short-label [PRO:DNx] synonym: "opsin-4" EXACT [] xref: IUPHARobj:2758 is_a: PR:000001119 ! animal opsin [Term] id: PR:000001244 name: long-wave-sensitive opsin 1 namespace: protein def: "An animal opsin that is a translation product of the human OPN1LW gene or a 1:1 ortholog thereof." [PRO:WCB] comment: Category=gene. synonym: "OPN1LW" EXACT PRO-short-label [PRO:DNx] synonym: "RCP" RELATED Gene-based [] synonym: "red cone photoreceptor pigment" EXACT [] synonym: "red-sensitive opsin" EXACT [] synonym: "ROP" EXACT [] xref: IUPHARobj:2961 is_a: PR:000001119 ! animal opsin [Term] id: PR:000001254 name: C-C chemokine receptor type 1 namespace: protein def: "A chemokine receptor CCR1/3/1L that is a translation product of the human CCR1 gene or a 1:1 ortholog thereof." [PRO:WCB] comment: Category=gene. Requested by=CL. synonym: "C-C CKR-1" EXACT [] synonym: "CC-CKR-1" EXACT [] synonym: "CCR-1" EXACT [] synonym: "CCR1" EXACT PRO-short-label [PRO:DNx] synonym: "CD191" EXACT [] synonym: "chemokine receptor CCR1" EXACT [] synonym: "CMKBR1" RELATED Gene-based [] synonym: "CMKR1" RELATED Gene-based [] synonym: "HM145" EXACT [] synonym: "LD78 receptor" EXACT [] synonym: "macrophage inflammatory protein 1-alpha receptor" EXACT [] synonym: "MIP-1alpha-R" EXACT [] synonym: "RANTES-R" EXACT [] synonym: "SCYAR1" RELATED Gene-based [] xref: IUPHARobj:58 is_a: PR:000001197 ! chemokine receptor CCR1/3/1L [Term] id: PR:000001255 name: C-C chemokine receptor type 3 namespace: protein def: "A chemokine receptor CCR1/3/1L that is a translation product of the human CCR3 gene or a 1:1 ortholog thereof." [PMID:12037138, PRO:WCB] comment: Category=gene. Requested by=CL. synonym: "C-C CKR-3" EXACT [] synonym: "CC-CKR-3" EXACT [] synonym: "CCR-3" EXACT [] synonym: "CCR3" EXACT PRO-short-label [PRO:DNx] synonym: "CD193" EXACT [] synonym: "chemokine receptor CCR3" EXACT [] synonym: "CKR3" EXACT [] synonym: "Cmkbr1l2" RELATED Gene-based [] synonym: "CMKBR3" RELATED Gene-based [] synonym: "eosinophil eotaxin receptor" EXACT [] synonym: "macrophage inflammatory protein 1-alpha receptor-like 2" EXACT [] synonym: "MIP-1 alpha RL2" EXACT [] xref: IUPHARobj:60 is_a: PR:000001197 ! chemokine receptor CCR1/3/1L [Term] id: PR:000001256 name: C-X-C chemokine receptor type 1 namespace: protein def: "A high affinity interleukin-8 receptor that is a translation product of the human CXCR1 gene or a 1:1 ortholog thereof." [PRO:WCB] comment: Category=gene. Requested by=CL. synonym: "CD181" EXACT [] synonym: "CDw128a" EXACT [] synonym: "CMKAR1" RELATED Gene-based [] synonym: "CXC-R1" EXACT [] synonym: "CXCR-1" EXACT [] synonym: "CXCR1" EXACT PRO-short-label [PRO:DNx] synonym: "high affinity interleukin-8 receptor A" EXACT [] synonym: "IL-8 receptor type 1" EXACT [] synonym: "IL-8R A" EXACT [] synonym: "IL8RA" RELATED Gene-based [] xref: IUPHARobj:68 is_a: PR:000001226 ! high affinity interleukin-8 receptor [Term] id: PR:000001257 name: C-X-C chemokine receptor type 2 namespace: protein def: "A high affinity interleukin-8 receptor that is a translation product of the human CXCR2 gene or a 1:1 ortholog thereof." [PRO:WCB] comment: Category=gene. Requested by=CL. synonym: "CD182" EXACT [] synonym: "CDw128b" EXACT [] synonym: "Cmkar2" RELATED Gene-based [] synonym: "CXC-R2" EXACT [] synonym: "CXCR-2" EXACT [] synonym: "CXCR2" EXACT PRO-short-label [PRO:DNx] synonym: "Gpcr16" RELATED Gene-based [] synonym: "GRO/MGSA receptor" EXACT [] synonym: "high affinity interleukin-8 receptor B" EXACT [] synonym: "IL-8 receptor type 2" EXACT [] synonym: "IL-8R B" EXACT [] synonym: "IL8RB" RELATED Gene-based [] xref: IUPHARobj:69 is_a: PR:000001226 ! high affinity interleukin-8 receptor [Term] id: PR:000001281 name: ADP-ribosyl cyclase namespace: protein def: "A protein that contains the ADP-ribosyl cyclase domain (Pfam:PF02267)." [PRO:WCB] comment: Category=family. xref: PIRSF:PIRSF005736 is_a: PR:000000001 ! protein [Term] id: PR:000001288 name: B-cell receptor CD22 namespace: protein def: "A protein that is a translation product of the human CD22 gene or a 1:1 ortholog thereof." [PRO:WCB] comment: Category=gene. Requested by=CL. synonym: "B-lymphocyte cell adhesion molecule" EXACT [] synonym: "BL-CAM" EXACT [] synonym: "CD22" EXACT PRO-short-label [PRO:DNx] synonym: "Lyb-8" RELATED Gene-based [] synonym: "sialic acid-binding Ig-like lectin 2" EXACT [] synonym: "siglec-2" EXACT [] synonym: "SIGLEC2" RELATED Gene-based [] synonym: "T-cell surface antigen Leu-14" EXACT [] xref: IUPHARobj:2786 is_a: PR:000000001 ! protein [Term] id: PR:000001289 name: membrane-spanning 4-domains subfamily A member 1 namespace: protein def: "A protein that is a translation product of the human MS4A1 gene or a 1:1 ortholog thereof." [PRO:WCB] comment: Category=gene. Requested by=CL. synonym: "B-cell differentiation antigen Ly-44" EXACT [] synonym: "B-cell surface antigen CD20" EXACT [] synonym: "B-lymphocyte antigen CD20" EXACT [] synonym: "B-lymphocyte surface antigen B1" EXACT [] synonym: "Bp35" EXACT [] synonym: "CD20" RELATED Gene-based [] synonym: "leukocyte surface antigen Leu-16" EXACT [] synonym: "Ly-44" RELATED Gene-based [] synonym: "lymphocyte antigen 44" EXACT [] synonym: "MS4A1" EXACT PRO-short-label [PRO:DNx] synonym: "Ms4a2" RELATED Gene-based [] xref: IUPHARobj:2628 xref: PIRSF:PIRSF001995 is_a: PR:000000001 ! protein [Term] id: PR:000001290 name: B7-related protein namespace: protein def: "A protein that is a member of a family that includes translation products of genes CD86, CD276, ICOSLG, and others. These are membrane-anchored proteins with a small intracellular domain and an extracellular domain with signal sequence, an Immunoglobulin V-set domain (Pfam:PF07686), and a CD80-like C2-set immunoglobulin domain (Pfam:PF08205)." [PRO:WCB] comment: Category=family. is_a: PR:000000001 ! protein [Term] id: PR:000001292 name: C-type lectin domain family 4 member C namespace: protein def: "A protein that is a translation product of the human CLEC4C gene or a 1:1 ortholog thereof." [PRO:WCB] comment: Category=gene. Requested by=CL. synonym: "BDCA-2" EXACT [] synonym: "BDCA2" RELATED Gene-based [] synonym: "blood dendritic cell antigen 2" EXACT [] synonym: "C-type lectin superfamily member 7" EXACT [] synonym: "CD303" EXACT [] synonym: "CLEC4C" EXACT PRO-short-label [PRO:DNx] synonym: "CLECSF11" RELATED Gene-based [] synonym: "CLECSF7" RELATED Gene-based [] synonym: "dendritic lectin" EXACT [] synonym: "DLEC" RELATED Gene-based [] synonym: "HECL" RELATED Gene-based [] synonym: "UNQ9361/PRO34150" RELATED Gene-based [] is_a: PR:000000001 ! protein [Term] id: PR:000001293 name: C-type lectin domain family 4 member K namespace: protein def: "A protein that is a translation product of the human CD207 gene or a 1:1 ortholog thereof." [PRO:WCB] comment: Category=gene. Requested by=CL. synonym: "CD207" EXACT PRO-short-label [PRO:DNx] synonym: "CLEC4K" RELATED Gene-based [] synonym: "langerin" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000001300 name: CD209 molecule namespace: protein def: "A protein that is a translation product of the human CD209 gene or a 1:1 ortholog thereof." [PRO:WCB] comment: Category=gene. This gene and CLEC4M are products of a recent gene duplication in the primate lineage. Independent duplications of an ancestral gene have given rise to several orthologs in rodents, including CD209A. Requested by=CL. synonym: "C-type lectin domain family 4 member L" EXACT [] synonym: "CD209" EXACT PRO-short-label [PRO:DNx] synonym: "CD209 antigen" EXACT [] synonym: "CLEC4L" RELATED Gene-based [] synonym: "DC-SIGN" RELATED [] synonym: "DC-SIGN1" EXACT [] synonym: "dendritic cell-specific ICAM-3-grabbing non-integrin 1" EXACT [] xref: IUPHARobj:2930 is_a: PR:000000001 ! protein [Term] id: PR:000001307 name: CD44 molecule namespace: protein def: "A protein that is a translation product of the human CD44 gene or a 1:1 ortholog thereof." [PRO:WCB] comment: Category=gene. Requested by=CL. synonym: "CD44" EXACT PRO-short-label [PRO:DNx] synonym: "CD44 antigen" EXACT [] synonym: "CDw44" EXACT [] synonym: "ECMR-III" EXACT [] synonym: "epican" EXACT [] synonym: "extracellular matrix receptor III" EXACT [] synonym: "GP90 lymphocyte homing/adhesion receptor" EXACT [] synonym: "heparan sulfate proteoglycan" EXACT [] synonym: "hermes antigen" EXACT [] synonym: "HUTCH-I" EXACT [] synonym: "hyaluronate receptor" EXACT [] synonym: "LHR" RELATED Gene-based [] synonym: "ly-24" EXACT [] synonym: "lymphocyte antigen 24" EXACT [] synonym: "MDU2" RELATED Gene-based [] synonym: "MDU3" RELATED Gene-based [] synonym: "MIC4" RELATED Gene-based [] synonym: "PGP-1" EXACT [] synonym: "PGP-I" RELATED [] synonym: "phagocytic glycoprotein 1" EXACT [] synonym: "phagocytic glycoprotein I" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000001308 name: CD48 molecule namespace: protein def: "A protein that is a translation product of the human CD48 gene or a 1:1 ortholog thereof." [PRO:WCB] comment: Category=gene. Requested by=CL. synonym: "B-lymphocyte activation marker BLAST-1" EXACT [] synonym: "Bcm-1" RELATED Gene-based [] synonym: "BCM1" RELATED Gene-based [] synonym: "BCM1 surface antigen" EXACT [] synonym: "BLAST-1" EXACT [] synonym: "BLAST1" RELATED Gene-based [] synonym: "CD48" EXACT PRO-short-label [PRO:DNx] synonym: "CD48 antigen" EXACT [] synonym: "HM48-1" EXACT [] synonym: "leukocyte antigen MEM-102" EXACT [] synonym: "MRC OX-45 surface antigen" EXACT [] synonym: "sgp-60" EXACT [] synonym: "signaling lymphocytic activation molecule 2" EXACT [] synonym: "SLAM family member 2" EXACT [] synonym: "SLAMF2" EXACT [] synonym: "TCT.1" EXACT [] xref: PIRSF:PIRSF001973 is_a: PR:000000001 ! protein [Term] id: PR:000001310 name: CD83 molecule namespace: protein def: "A protein that is a translation product of the human CD83 gene or a 1:1 ortholog thereof." [PRO:WCB] comment: Category=gene. Requested by=CL. synonym: "B-cell activation protein" EXACT [] synonym: "CD83" EXACT PRO-short-label [PRO:DNx] synonym: "CD83 antigen" EXACT [] synonym: "cell surface protein HB15" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000001313 name: E/P-selectin namespace: protein def: "A protein with core domain structure consisting of one lectin C-type domain (Pfam:PF00059), followed by one EGF domain (Pfam:PF00008), followed by 4-9 sushi domains (Pfam:PF00084), with the P-selectins generally being longer." [PRO:WCB] comment: Category=family. xref: PIRSF:PIRSF036331 is_a: PR:000000001 ! protein [Term] id: PR:000001318 name: L-selectin namespace: protein def: "A protein that is a translation product of the human SELL gene or a 1:1 ortholog thereof. It is a leukocyte adhesion receptor that play an important role in regulating the inflammatory response by mediating leukocyte tethering and rolling on adherent leukocytes." [PMID:12403782, PRO:JAN] comment: Category=gene. Requested by=CL. synonym: "CD62 antigen-like family member L" EXACT [] synonym: "CD62L" EXACT [] synonym: "gp90-MEL" EXACT [] synonym: "LAM-1" EXACT [] synonym: "LECAM1" EXACT [] synonym: "leukocyte adhesion molecule 1" EXACT [] synonym: "leukocyte surface antigen Leu-8" EXACT [] synonym: "leukocyte-endothelial cell adhesion molecule 1" EXACT [] synonym: "LNHR" RELATED Gene-based [] synonym: "ly-22" EXACT [] synonym: "Ly22" RELATED Gene-based [] synonym: "LYAM1" RELATED Gene-based [] synonym: "lymph node homing receptor" EXACT [] synonym: "lymphocyte antigen 22" EXACT [] synonym: "lymphocyte surface MEL-14 antigen" EXACT [] synonym: "SELL" EXACT PRO-short-label [PRO:DNx] synonym: "TQ1" EXACT [] xref: PIRSF:PIRSF002421 is_a: PR:000000001 ! protein [Term] id: PR:000001319 name: SLAM family member 5 namespace: protein def: "A protein that is a translation product of the human CD84 gene or a 1:1 ortholog thereof." [PRO:WCB] comment: Category=gene. Requested by=CL. synonym: "CD84" EXACT PRO-short-label [PRO:DNx] synonym: "cell surface antigen MAX.3" EXACT [] synonym: "hly9-beta" EXACT [] synonym: "leukocyte differentiation antigen CD84" EXACT [] synonym: "signaling lymphocytic activation molecule 5" EXACT [] synonym: "SLAMF5" RELATED Gene-based [] is_a: PR:000000001 ! protein [Term] id: PR:000001320 name: alpha-(1,3)-fucosyltransferase namespace: protein def: "A protein that is a stand alone version of the Glycosyltransferase family 10 (fucosyltransferase) (Pfam:PF00852) domain. Proteins in this class may catalyze alpha-1,3 glycosidic linkages." [PMID:9451017] comment: Category=family. xref: PIRSF:PIRSF005726 is_a: PR:000000001 ! protein [Term] id: PR:000001325 name: beta-1,3-glucuronyltransferase namespace: protein def: "A protein with a core domain structure consisting of a very small cytoplasmic domain followed by a transmembrane domain and a Glycosyltransferase family 43 (Pfam:PF03360) domain." [PRO:WCB] comment: Category=family. xref: PIRSF:PIRSF016413 is_a: PR:000000001 ! protein [Term] id: PR:000001326 name: bone marrow stromal antigen 2 namespace: protein def: "A protein that is a translation product of the human BST2 gene or a 1:1 ortholog thereof." [PRO:WCB] comment: Category=gene. Requested by=CL. synonym: "BST-2" EXACT [] synonym: "BST2" EXACT PRO-short-label [PRO:DNx] synonym: "CD317" EXACT [] synonym: "HM1.24 antigen" EXACT [] synonym: "tetherin" EXACT [] xref: PIRSF:PIRSF023920 is_a: PR:000000001 ! protein [Term] id: PR:000001327 name: cadherin namespace: protein def: "A protein that has a core domain structure of signal sequence, propeptide, five Cadherin domains (Pfam:PF00028), a transmembrane region, and a Cadherin cytoplasmic region (Pfam:PF01049). Cadherins function as adhesion molecules that mediate Ca2+-dependent cell-cell adhesion in solid tissues." [PRO:WCB] comment: Category=family. xref: PIRSF:PIRSF002504 is_a: PR:000000001 ! protein [Term] id: PR:000001332 name: cell adhesion molecule CEACAM8 namespace: protein def: "A protein that is a translation product of the human CEACAM8 gene or a 1:1 ortholog thereof." [PRO:CNA] comment: Category=gene. Requested by=CL. synonym: "carcinoembryonic antigen CGM6" EXACT [] synonym: "carcinoembryonic antigen-related cell adhesion molecule 8" EXACT [] synonym: "CD66b" EXACT [] synonym: "CD67 antigen" EXACT [] synonym: "CEACAM8" EXACT PRO-short-label [PRO:DNx] synonym: "CGM6" RELATED Gene-based [] synonym: "non-specific cross-reacting antigen NCA-95" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000001337 name: complement receptor type 1 namespace: protein def: "A protein that is a translation product of the human CR1 gene or a 1:1 ortholog thereof." [PRO:WCB] comment: Category=gene. Requested by=CL. Note: There is no counterpart in mouse. synonym: "C3b/C4b receptor" EXACT [] synonym: "C3BR" RELATED Gene-based [] synonym: "CD35" EXACT [] synonym: "CR1" EXACT PRO-short-label [PRO:DNx] is_a: PR:000000001 ! protein [Term] id: PR:000001338 name: complement receptor type 2 namespace: protein def: "A protein that is a translation product of the human CR2 gene or a 1:1 ortholog thereof." [PRO:WCB] comment: Category=gene. Requested by=CL. synonym: "C3DR" RELATED Gene-based [] synonym: "CD21" EXACT [] synonym: "complement C3d receptor" EXACT [] synonym: "CR2" EXACT PRO-short-label [PRO:DNx] synonym: "Cr2" EXACT [] synonym: "EBV receptor" EXACT [] synonym: "epstein-Barr virus receptor" EXACT [] xref: PIRSF:PIRSF002484 is_a: CHEBI:36080 [Term] id: PR:000001343 name: CD69 molecule namespace: protein def: "A protein that is a translation product of the human CD69 gene or a 1:1 ortholog thereof. A type II transmembrane protein with a C-type lectin binding domain in the extracellular portion of the molecule. Involved in lymphocyte proliferation and functions as a signal transmitting receptor in lymphocytes, natural killer (NK) cells, and platelets." [PMID:10466080, PRO:CNA, UniProtKB:Q07108] comment: Category=gene. Requested by=CL. synonym: "activation inducer molecule" EXACT [] synonym: "AIM" EXACT [] synonym: "BL-AC/P26" EXACT [] synonym: "C-type lectin domain family 2 member C" EXACT [] synonym: "CD69" EXACT PRO-short-label [PRO:DNx] synonym: "CLEC2C" RELATED Gene-based [] synonym: "EA1" EXACT [] synonym: "early activation antigen CD69" EXACT [] synonym: "early T-cell activation antigen p60" EXACT [] synonym: "GP32/28" EXACT [] synonym: "leukocyte surface antigen Leu-23" EXACT [] synonym: "MLR-3" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000001344 name: ectonucleotide pyrophosphatase/phosphodiesterase family member 3 namespace: protein def: "A protein that is a translation product of the human ENPP3 gene or a 1:1 ortholog thereof." [PRO:WCB] comment: Category=gene. Requested by=CL. synonym: "CD203c" EXACT [] synonym: "dinucleoside polyphosphatase" EXACT [] synonym: "E-NPP 3" EXACT [] synonym: "ectonucleotide pyrophosphatase/phosphodiesterase 3" EXACT [] synonym: "ENPP3" EXACT PRO-short-label [PRO:DNx] synonym: "PD-Ibeta" EXACT [] synonym: "PDNP3" RELATED Gene-based [] synonym: "phosphodiesterase I beta" EXACT [] synonym: "phosphodiesterase I/nucleotide pyrophosphatase 3" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000001345 name: endoglin namespace: protein def: "A protein that is a translation product of the human ENG gene or a 1:1 ortholog thereof." [PRO:CNA] comment: Category=gene. Requested by=CL. synonym: "CD105" EXACT [] synonym: "cell surface MJ7/18 antigen" EXACT [] synonym: "Edg" RELATED Gene-based [] synonym: "END" RELATED Gene-based [] synonym: "ENG" EXACT PRO-short-label [PRO:DNx] xref: IUPHARobj:2895 xref: PIRSF:PIRSF038746 is_a: PR:000000001 ! protein [Term] id: PR:000001350 name: forkhead box protein P3 namespace: protein def: "A protein that is a translation product of the human FOXP3 gene or a 1:1 ortholog thereof." [PRO:CNA] comment: Category=gene. Requested by=CL. synonym: "FOXP3" EXACT PRO-short-label [PRO:DNx] synonym: "IPEX" RELATED Gene-based [] synonym: "JM2" RELATED Gene-based [] synonym: "scurfin" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000001352 name: glycophorin namespace: protein def: "A protein that contains an extracellular Glycophorin A domain (Pfam:PF01102), followed by a single-pass transmembrane region and a small intracellular domain. A protein that is an integral protein of the red cell membrane. Proteins in this class are responsible for the molecular basis of the blood group antigens, surface markers on the outside of the red blood cell membrane." [InterPro:IPR001195, PRO:CNA] comment: Category=family. xref: PIRSF:PIRSF002466 is_a: PR:000000001 ! protein [Term] id: PR:000001355 name: immunoglobulin gamma Fc receptor II/III/IV namespace: protein def: "A protein with a core domain architecture consisting of an extracellular domain containing two copies of the Immunoglobulin domain (Pfam:PF00047), followed by a single-pass transmembrane region and a small intracellular domain. The active protein is a low affinity receptor for immunoglobulin gamma chain Fc region. Human II-a, II-b, and II-c represent a recent gene expansion and are equally related to mouse II, III, and IV. Human III-A and III-B are closely related and closer to mouse IV than to mouse III." [PRO:WCB] comment: Category=family. xref: PIRSF:PIRSF001980 is_a: PR:000000001 ! protein [Term] id: PR:000001356 name: immunoglobulin gamma Fc receptor I namespace: protein def: "A protein with a core domain architecture consisting of an extracellular domain containing two or three copies of the Immunoglobulin domain (Pfam:PF00047), followed by a single-pass transmembrane region and a small intracellular domain." [PRO:CNA] comment: Category=family. Note: The active protein is a low affinity receptor for immunoglobulin gamma chain Fc region. It comprises the translation products of the FCGR1 gene (mouse) or one of the closely related FCGR1A, FCGR1B, or FCGR1C genes (human). FCGR1C may be a pseudogene in human. synonym: "Fc-gamma receptor" RELATED [] xref: PIRSF:PIRSF001981 is_a: PR:000000001 ! protein [Term] id: PR:000001380 name: interleukin-2 receptor subunit alpha namespace: protein def: "A protein that is a translation product of the human IL2RA gene or a 1:1 ortholog thereof." [PRO:CNA] comment: Category=gene. Requested by=CL. synonym: "CD25" EXACT [] synonym: "IL-2 receptor subunit alpha" EXACT [] synonym: "IL-2-RA" EXACT [] synonym: "IL-2R subunit alpha" EXACT [] synonym: "IL2-RA" EXACT [] synonym: "Il2r" RELATED Gene-based [] synonym: "IL2RA" EXACT PRO-short-label [PRO:DNx] synonym: "p55" BROAD [PRO:DNx] synonym: "TAC antigen" EXACT [] xref: IUPHARobj:1695 xref: PIRSF:PIRSF001954 is_a: PR:000000001 ! protein [Term] id: PR:000001381 name: interleukin-2 receptor subunit beta namespace: protein def: "A protein that is a translation product of the human IL2RB gene or a 1:1 ortholog thereof." [PRO:CNA] comment: Category=gene. Requested by=CL. synonym: "CD122" EXACT [] synonym: "high affinity IL-2 receptor subunit beta" EXACT [] synonym: "IL-2 receptor subunit beta" EXACT [] synonym: "IL-2R subunit beta" EXACT [] synonym: "IL-2RB" EXACT [] synonym: "IL15RB" RELATED Gene-based [] synonym: "IL2RB" EXACT PRO-short-label [PRO:DNx] synonym: "p70-75" EXACT [] synonym: "p75" BROAD [PRO:DNx] xref: IUPHARobj:1696 is_a: PR:000000001 ! protein [Term] id: PR:000001398 name: leukocyte immunoglobulin-like receptor subfamily A member 4 namespace: protein def: "A leukocyte immunoglobulin-like receptor subfamily member that is a translation product of the human LILRA4 gene or a 1:1 ortholog thereof. This gene is a member of a lineage-specific gene expansion in primates." [PRO:WCB] comment: Category=gene. Requested by=CL. synonym: "CD85 antigen-like family member G" EXACT [] synonym: "CD85g" EXACT [] synonym: "ILT-7" EXACT [] synonym: "ILT7" RELATED Gene-based [] synonym: "immunoglobulin-like transcript 7" EXACT [] synonym: "LILRA4" EXACT PRO-short-label [PRO:DNx] xref: IUPHARobj:2896 is_a: PR:000044780 ! leukocyte immunoglobulin-like receptor subfamily member [Term] id: PR:000001402 name: killer cell lectin-like receptor subfamily D member 1 namespace: protein def: "A protein that is a translation product of the human KLRD1 gene or a 1:1 ortholog thereof." [PRO:WCB] comment: Category=gene. Requested by=CL. synonym: "CD94" RELATED Gene-based [] synonym: "KLRD1" EXACT PRO-short-label [PRO:DNx] synonym: "KP43" EXACT [] synonym: "natural killer cells antigen CD94" EXACT [] synonym: "NK cell receptor" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000001403 name: tetraspanin namespace: protein def: "A protein with four transmembrane domains, small intracellular amino- and carboxyl-terminal regions, and two extracellular loops, a small one (EC1) and a larger one (EC2) of about 100 residues. The EC2 loop contains at least four cysteine residues, including a highly conserved 'CCG' motif." [PRO:WCB, Wikipedia:Tetraspanin] comment: Category=family. xref: PIRSF:PIRSF002419 is_a: PR:000000001 ! protein [Term] id: PR:000001408 name: ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 namespace: protein def: "An ADP-ribosyl cyclase that is a translation product of the human CD38 gene or a 1:1 ortholog thereof." [PRO:WCB] comment: Category=gene. Requested by=CL. synonym: "2'-phospho-ADP-ribosyl cyclase" EXACT [] synonym: "2'-phospho-ADP-ribosyl cyclase/2'-phospho-cyclic-ADP-ribose transferase" EXACT [] synonym: "2'-phospho-cyclic-ADP-ribose transferase" EXACT [] synonym: "ADP-ribosyl cyclase 1" EXACT [] synonym: "ADPRC 1" EXACT [] synonym: "cADPr hydrolase 1" EXACT [] synonym: "CD38" EXACT PRO-short-label [PRO:DNx] synonym: "cyclic ADP-ribose hydrolase 1" EXACT [] synonym: "I-19" EXACT [] synonym: "NIM-R5 antigen" EXACT [] synonym: "T10" EXACT [] xref: IUPHARobj:2766 is_a: PR:000001281 ! ADP-ribosyl cyclase [Term] id: PR:000001412 name: CD86 molecule namespace: protein def: "A B7-related protein that is a translation product of the human CD86 gene or a 1:1 ortholog thereof." [PRO:WCB] comment: Category=gene. Requested by=CL. synonym: "activation B7-2 antigen" EXACT [] synonym: "B70" EXACT [] synonym: "BU63" EXACT [] synonym: "CD28LG2" RELATED Gene-based [] synonym: "CD86" EXACT PRO-short-label [PRO:DNx] synonym: "CD86 antigen" EXACT [] synonym: "CTLA-4 counter-receptor B7.2" EXACT [] synonym: "early T-cell costimulatory molecule 1" EXACT [] synonym: "ETC-1" EXACT [] synonym: "FUN-1" EXACT [] synonym: "T-lymphocyte activation antigen CD86" EXACT [] xref: IUPHARobj:2745 is_a: PR:000001290 ! B7-related protein [Term] id: PR:000001431 name: N-formyl peptide receptor namespace: protein def: "A rhodopsin-like G-protein coupled receptor that is a translation product of the human FPR1, FPR2, or FPR3 genes, 1:1 orthologs thereof, or a semi-ortholog thereof. The active form binds N-formyl methionyl peptides." [InterPro:IPR000826, PRO:DAN, PRO:WCB, PRO:XQ] comment: Category=family. synonym: "formylpeptide receptor" EXACT [IUPHARfam:23] xref: IUPHARfam:23 xref: PIRSF:PIRSF038561 is_a: PR:000001094 ! rhodopsin-like G-protein coupled receptor [Term] id: PR:000001432 name: P-selectin namespace: protein def: "An E/P-selectin that is a translation product of the human SELP gene or a 1:1 ortholog thereof." [PRO:WCB] comment: Category=gene. synonym: "CD62 antigen-like family member P" EXACT [] synonym: "CD62P" EXACT [] synonym: "GMP-140" EXACT [] synonym: "GMRP" RELATED Gene-based [] synonym: "granule membrane protein 140" EXACT [] synonym: "GRMP" RELATED Gene-based [] synonym: "LECAM3" EXACT [] synonym: "leukocyte-endothelial cell adhesion molecule 3" EXACT [] synonym: "PADGEM" EXACT [] synonym: "platelet activation dependent granule-external membrane protein" EXACT [] synonym: "SELP" EXACT PRO-short-label [PRO:DNx] xref: PIRSF:PIRSF500801 is_a: PR:000001313 ! E/P-selectin [Term] id: PR:000001438 name: CD80 molecule namespace: protein def: "A B7-related protein that is a translation product of the human CD80 gene or a 1:1 ortholog thereof." [PRO:WCB] comment: Category=gene. Requested by=CL. synonym: "activation B7-1 antigen" EXACT [] synonym: "B7" RELATED Gene-based [] synonym: "BB1" EXACT [] synonym: "CD28LG" RELATED Gene-based [] synonym: "CD28LG1" RELATED Gene-based [] synonym: "CD80" EXACT PRO-short-label [PRO:DNx] synonym: "CTLA-4 counter-receptor B7.1" EXACT [] synonym: "LAB7" RELATED Gene-based [] synonym: "T-lymphocyte activation antigen CD80" EXACT [] xref: IUPHARobj:2744 is_a: PR:000001290 ! B7-related protein [Term] id: PR:000001440 name: galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1 namespace: protein def: "A beta-1,3-glucuronyltransferase that is a translation product of the human B3GAT1 gene or a 1:1 ortholog thereof." [PRO:WCB] comment: Category=gene. synonym: "B3GAT1" EXACT PRO-short-label [PRO:DNx] synonym: "beta-1,3-glucuronyltransferase 1" EXACT [] synonym: "GlcAT-P" EXACT [] synonym: "GLCATP" RELATED Gene-based [] synonym: "GlcUAT-P" EXACT [] synonym: "glucuronosyltransferase P" EXACT [] synonym: "UDP-GlcUA:glycoprotein beta-1,3-glucuronyltransferase" EXACT [] is_a: PR:000001325 ! beta-1,3-glucuronyltransferase [Term] id: PR:000001444 name: cadherin-5 namespace: protein def: "A cadherin that is a translation product of the human CDH5 gene or a 1:1 ortholog thereof." [PRO:WCB] comment: Category=gene. Requested by=CL. synonym: "7B4 antigen" EXACT [] synonym: "CD144" EXACT [] synonym: "CDH5" EXACT PRO-short-label [PRO:DNx] synonym: "vascular endothelial cadherin" EXACT [] synonym: "VE-cadherin" EXACT [] is_a: PR:000001327 ! cadherin [Term] id: PR:000001447 name: cadherin-1 namespace: protein def: "A cadherin that is a translation product of the human CDH1 gene or a 1:1 ortholog thereof." [PRO:WCB] comment: Category=gene. Requested by=CL. synonym: "ARC-1" EXACT [] synonym: "CAM 120/80" EXACT [] synonym: "CD324" EXACT [] synonym: "CDH1" EXACT PRO-short-label [PRO:DNx] synonym: "CDHE" RELATED Gene-based [] synonym: "E-cadherin" EXACT [] synonym: "epithelial cadherin" EXACT [] synonym: "UVO" RELATED Gene-based [] synonym: "uvomorulin" EXACT [] is_a: PR:000001327 ! cadherin [Term] id: PR:000001456 name: alpha-(1,3)-fucosyltransferase 4 namespace: protein def: "An alpha-(1,3)-fucosyltransferase that is a translation product of the human FUT4 gene or a 1:1 ortholog thereof." [PRO:CNA] comment: Category=gene. Requested by=CL. synonym: "alpha-(1,3)-fucosyltransferase FUT4" EXACT [] synonym: "CD15" EXACT [] synonym: "ELAM-1 ligand fucosyltransferase" EXACT [] synonym: "ELFT" RELATED Gene-based [] synonym: "FCT3A" RELATED Gene-based [] synonym: "Fuc-TIV" EXACT [] synonym: "fucosyltransferase 4" EXACT [] synonym: "fucosyltransferase FUT4" EXACT [] synonym: "fucosyltransferase IV" EXACT [] synonym: "FucT-IV" EXACT [] synonym: "FUT4" EXACT PRO-short-label [PRO:DNx] synonym: "galactoside 3-L-fucosyltransferase" BROAD [PRO:DNx] is_a: PR:000001320 ! alpha-(1,3)-fucosyltransferase [Term] id: PR:000001460 name: glycophorin-A namespace: protein def: "A glycophorin that is a translation product of the human GYPA gene or a 1:1 ortholog thereof. It is the major sialoglycoprotein of the erythrocyte membrane. Structurally, glycophorin A consists of an N-terminal extracellular domain, heavily glycosylated on Ser and threonine residues, followed by a transmembrane region and a C-terminal cytoplasmic domain." [InterPro:IPR001195, PRO:CNA] comment: Category=gene. Requested by=CL. synonym: "CD235a" EXACT [] synonym: "GPA" RELATED Gene-based [] synonym: "GYPA" EXACT PRO-short-label [PRO:DNx] synonym: "MN sialoglycoprotein" EXACT [] synonym: "MNS" RELATED Gene-based [] synonym: "PAS-2" EXACT [] synonym: "sialoglycoprotein alpha" EXACT [] is_a: PR:000001352 ! glycophorin [Term] id: PR:000001465 name: high affinity immunoglobulin gamma Fc receptor I namespace: protein def: "An immunoglobulin gamma Fc receptor I that is a translation product of the human FCGR1A gene or a 1:1 ortholog thereof." [PRO:CNA] comment: Category=gene. The Fcgr1 gene in mouse is a 1:1 ortholog of FCGR1A, not FCGR1B. Requested by=CL. synonym: "CD64" EXACT [] synonym: "Fc-gamma RI" EXACT [] synonym: "FCG1" RELATED Gene-based [] synonym: "FCGR1" RELATED Gene-based [] synonym: "FCGR1A" EXACT PRO-short-label [PRO:DNx] synonym: "FcRI" EXACT [] synonym: "IGFR1" RELATED Gene-based [] synonym: "IgG Fc receptor I" EXACT [] is_a: PR:000001356 ! immunoglobulin gamma Fc receptor I [Term] id: PR:000001479 name: low affinity immunoglobulin gamma Fc region receptor II namespace: protein def: "An immunoglobulin gamma Fc receptor II/III/IV that is a translation product of the mouse Fcgr2 gene or a 1:1 ortholog thereof." [PRO:CNA] comment: Category=gene. Requested by=CL. synonym: "CD32" BROAD [PRO:DNx] synonym: "Fc gamma receptor IIB" EXACT [] synonym: "Fc-gamma RII" EXACT [] synonym: "Fc-gamma-RIIB" EXACT [] synonym: "Fcgr2" EXACT PRO-short-label [PRO:DNx] synonym: "Fcgr2b" RELATED Gene-based [] synonym: "FcRII" EXACT [] synonym: "IgG Fc receptor II beta" EXACT [] synonym: "ly-17" EXACT [] synonym: "lymphocyte antigen 17" EXACT [] is_a: PR:000001355 ! immunoglobulin gamma Fc receptor II/III/IV [Term] id: PR:000001481 name: low affinity immunoglobulin gamma Fc region receptor II-b namespace: protein def: "An immunoglobulin gamma Fc receptor II/III/IV that is a translation product of the human FCGR2B gene or a 1:1 ortholog thereof." [PRO:CNA] comment: Category=gene. Requested by=CL. synonym: "CD32" BROAD Gene-based [PRO:DNx] synonym: "CDw32" BROAD [PRO:DNx] synonym: "Fc-gamma RII-b" EXACT [] synonym: "Fc-gamma-RIIb" EXACT [] synonym: "FCG2" RELATED Gene-based [] synonym: "FCGR2B" EXACT PRO-short-label [PRO:DNx] synonym: "FcRII-b" EXACT [] synonym: "IGFR2" RELATED Gene-based [] synonym: "IgG Fc receptor II-b" EXACT [] is_a: PR:000001355 ! immunoglobulin gamma Fc receptor II/III/IV [Term] id: PR:000001483 name: low affinity immunoglobulin gamma Fc region receptor III namespace: protein def: "An immunoglobulin gamma Fc receptor II/III/IV that is a translation product of the mouse Fcgr3 gene or a 1:1 ortholog thereof." [PRO:CNA] comment: Category=gene. Requested by=CL. synonym: "CD16" EXACT [] synonym: "Fc-gamma RIII" EXACT [] synonym: "Fcgr3" EXACT PRO-short-label [PRO:DNx] synonym: "FcRIII" EXACT [] synonym: "IgG Fc receptor III" EXACT [] is_a: PR:000001355 ! immunoglobulin gamma Fc receptor II/III/IV [Term] id: PR:000001547 name: prostaglandin D2 receptor DP2 namespace: protein def: "A prostanoid receptor that is a translation product of the human PTGDR2 gene or a 1:1 ortholog thereof. The preferred ligand is 11-dehydro-thromboxane B2. This receptor is not closely related to the prostaglandin D2 receptor encoded by PGD2." [PRO:WCB] comment: Category=gene. synonym: "CD294" EXACT [] synonym: "chemoattractant receptor-homologous molecule expressed on Th2 cells" EXACT [] synonym: "CRTH2" RELATED Gene-based [] synonym: "DL1R" RELATED Gene-based [] synonym: "G-protein coupled receptor 44" EXACT [] synonym: "GPR44" RELATED Gene-based [] synonym: "PTGDR2" EXACT PRO-short-label [PRO:DNx] xref: IUPHARobj:339 xref: PIRSF:PIRSF038608 is_a: PR:000001549 ! prostanoid receptor [Term] id: PR:000001549 name: prostanoid receptor namespace: protein def: "A rhodopsin-like G-protein coupled receptor that is a translation product of the human PTGDR, PTGDR2, PTGER1 to PTGER4, PTGFR, PTGIR, or TBXA2R genes, 1:1 orthologs thereof, or a semi-ortholog thereof. The active form binds prostanoids (prostaglandins and thromboxanes)." [PMID:7938166, PRO:WCB, PRO:XQ] comment: Category=family. xref: IUPHARfam:58 xref: PIRSF:PIRSF001962 is_a: PR:000001094 ! rhodopsin-like G-protein coupled receptor [Term] id: PR:000001551 name: relaxin family peptide receptor protein namespace: protein def: "A rhodopsin-like G-protein coupled receptor that is a translation product of the human RXFP1 to RXFP4 genes, 1:1 orthologs thereof, or a semi-ortholog thereof. The active form binds relaxins." [PRO:WCB, PRO:XQ] comment: Category=family. synonym: "fam:RXFP" EXACT PRO-short-label [PRO:DNx] synonym: "relaxin receptor" EXACT [] xref: IUPHARfam:60 xref: PIRSF:PIRSF038662 is_a: PR:000001094 ! rhodopsin-like G-protein coupled receptor [Term] id: PR:000001562 name: vasopressin/oxytocin receptor namespace: protein def: "A rhodopsin-like G-protein coupled receptor that is a translation product of the human AVPR1A, AVPR1B, AVPR2, or OXTR genes, 1:1 orthologs thereof, or a semi-ortholog thereof. These receptors bind vasopressin or oxytocin or related nonapeptides." [PRO:WCB, PRO:XQ, Wikipedia:Vasopressin, Wikipedia:Vasopressin_receptor] comment: Category=family. synonym: "name: vasopressin and oxytocin receptor" EXACT [IUPHARfam:66] xref: IUPHARfam:66 xref: PIRSF:PIRSF001841 is_a: PR:000001094 ! rhodopsin-like G-protein coupled receptor [Term] id: PR:000001580 name: fMet-Leu-Phe receptor namespace: protein def: "An N-formyl peptide receptor that is a translation product of the human FPR1 gene or a 1:1 ortholog thereof. The preferred ligand is the peptide fMet-Leu-Phe, a bacterial peptide that acts as a chemoattractant in various pathophysiological conditions." [InterPro:IPR000826, PRO:WCB] comment: Category=gene. Requested by=CL. synonym: "fMLP receptor" EXACT [] synonym: "FPR" EXACT [] synonym: "FPR1" EXACT PRO-short-label [PRO:DNx] synonym: "N-formyl peptide receptor" BROAD [PRO:DNx] synonym: "N-formylpeptide chemoattractant receptor" EXACT [] xref: IUPHARobj:222 is_a: PR:000001431 ! N-formyl peptide receptor [Term] id: PR:000001635 name: oxytocin receptor namespace: protein def: "A vasopressin/oxytocin receptor that is a translation product of the human OXTR gene or a 1:1 ortholog thereof. The preferred ligand is oxytocin." [PRO:WCB] comment: Category=gene. synonym: "OT-R" EXACT [] synonym: "OXTR" EXACT PRO-short-label [PRO:DNx] xref: IUPHARobj:369 is_a: PR:000001562 ! vasopressin/oxytocin receptor [Term] id: PR:000001666 name: relaxin receptor 1 namespace: protein def: "A relaxin family peptide receptor protein that is a translation product of the human RXFP1 gene or a 1:1 ortholog thereof. This receptor is expressed in the brain, kidney, testis, placenta, uterus, ovary, adrenal, prostate, skin and heart." [PRO:WCB, UniProtKB:Q9HBX9] comment: Category=gene. synonym: "Gm1018" RELATED Gene-based [] synonym: "leucine-rich repeat-containing G-protein coupled receptor 7" EXACT [] synonym: "LGR7" RELATED Gene-based [] synonym: "relaxin family peptide receptor 1" EXACT [] synonym: "RXFP1" EXACT PRO-short-label [PRO:DNx] xref: IUPHARobj:351 is_a: PR:000001551 ! relaxin family peptide receptor protein [Term] id: PR:000001753 name: transcription factor NF-kappa-B subunit namespace: protein def: "A protein that has a core domain composition consisting of a Rel homology domain (RHD) (Pfam:PF00554), an IPT/TIG domain (Pfam:PF01833), six copies of the Ankyrin repeat (Pfam:PF00023), a Death domain (Pfam:PF00531) and a C-terminal PEST region." [PRO:JAN] comment: Category=family. synonym: "transcription factor NF-kappa-B" RELATED [] xref: PIRSF:PIRSF036310 is_a: PR:000000001 ! protein [Term] id: PR:000001785 name: prominin namespace: protein def: "A protein with core architecture consisting of one Prominin (Pfam:PF05478) domain. The prominins are an emerging family of proteins that, among the multispan membrane proteins, display a novel topology. Mouse and human prominin and prominin-like 1 are predicted to contain five membrane spanning domains, with an N-terminal domain exposed to the extracellular space followed by four, alternating small cytoplasmic and large extracellular, loops and a cytoplasmic C-terminal domain." [InterPro:IPR008795, PMID:11467842] comment: Category=family. xref: PIRSF:PIRSF017831 is_a: PR:000000001 ! protein [Term] id: PR:000001786 name: prominin-1 namespace: protein def: "A prominin that is a translation product of the human PROM1 gene or a 1:1 ortholog thereof." [PRO:CNA] comment: Category=gene. Requested by=CL. synonym: "antigen AC133" EXACT [] synonym: "antigen AC133 homolog" EXACT [] synonym: "CD133" EXACT [] synonym: "MSTP061" RELATED Gene-based [] synonym: "Prom" RELATED Gene-based [] synonym: "PROM1" EXACT PRO-short-label [PRO:DNx] synonym: "prominin-like protein 1" EXACT [] synonym: "PROML1" RELATED Gene-based [] is_a: PR:000001785 ! prominin [Term] id: PR:000001806 name: C-type lectin domain family 6 member A namespace: protein def: "A protein that is a translation product of the human CLEC6A gene or a 1:1 ortholog thereof." [PRO:WCB] comment: Category=gene. Requested by=CL. synonym: "C-type lectin superfamily member 10" EXACT [] synonym: "Clec4n" RELATED Gene-based [] synonym: "CLEC6A" EXACT PRO-short-label [PRO:DNx] synonym: "CLECSF10" RELATED Gene-based [] synonym: "DC-associated C-type lectin 2" EXACT [] synonym: "dectin-2" EXACT [] synonym: "DECTIN2" RELATED Gene-based [] synonym: "dendritic cell-associated C-type lectin 2" EXACT [] xref: IUPHARobj:2928 is_a: PR:000000001 ! protein [Term] id: PR:000001807 name: C-type lectin domain family 7 member A namespace: protein def: "A protein that is a translation product of the human CLEC7A gene or a 1:1 ortholog thereof." [PRO:WCB] comment: Category=gene. Requested by=CL. synonym: "beta-glucan receptor" EXACT [] synonym: "BGR" RELATED Gene-based [] synonym: "C-type lectin superfamily member 12" EXACT [] synonym: "CD369" EXACT [] synonym: "CLEC7A" EXACT PRO-short-label [PRO:DNx] synonym: "CLECSF12" RELATED Gene-based [] synonym: "DC-associated C-type lectin 1" EXACT [] synonym: "dectin-1" EXACT [] synonym: "DECTIN1" RELATED Gene-based [] synonym: "dendritic cell-associated C-type lectin 1" EXACT [] synonym: "UNQ539/PRO1082" RELATED Gene-based [] xref: IUPHARobj:2927 is_a: PR:000000001 ! protein [Term] id: PR:000001808 name: C/C-C motif small inducible chemokine namespace: protein def: "A protein with core architecture consisting of a Small cytokines (intecrine/chemokine), interleukin-8 like (Pfam:PF00048) domain." [PRO:WCB] comment: Category=family. synonym: "fam:C/C-C chemokine" EXACT PRO-short-label [PRO:DAN] xref: PIRSF:PIRSF001950 is_a: CHEBI:36080 [Term] id: PR:000001809 name: CD59-like glycoprotein namespace: protein def: "A protein that is a translation product of the human CD59 gene, a 1:1 ortholog thereof, or pro-orthologs thereof." [PRO:WCB] comment: Category=gene. Requested by=CL. Pro-orthology refers to, in this case, after-speciation gene duplication in the non-human species (aka 1:many orthology). This gene is present as a single copy in human and has undergone a lineage-specific duplication in mouse. CD59 antigen has a core architecture consisting of one UPAR/Ly-6 domain (Pfam:PF00021), a small domain of about 70 amino acids and containing 5 conserved disulfide bonds. It is both N- and O-glycosylated and is a GPI-anchored protein that releases soluble forms in some tissues. synonym: "CD59-like" EXACT PRO-short-label [PRO:DNx] xref: PIRSF:PIRSF038782 is_a: PR:000000001 ! protein [Term] id: PR:000001810 name: CSF-1/PDGF receptor-type tyrosine-protein kinase namespace: protein def: "A protein with core architecture consisting of asignal sequence, 5 Ig-like domains, followed by a transmembrane sequence, followed by a Protein tyrosine kinase domain (Pfam:PF07714). However, only 1-3 of the Ig domains are detected by the Pfam HMMs in most of the sequences. Pfam:PF00047 is most common, but other members of the Ig domain clan, Pfam:PF07679 and Pfam:PF07686 can be identified instead. The fourth Ig domain lacks the disulfide-bonded cysteines." [PRO:WCB] comment: Category=family. xref: PIRSF:PIRSF000615 is_a: PR:000000001 ! protein [Term] id: PR:000001813 name: adhesion G protein-coupled receptor E1 namespace: protein def: "An adhesion G-protein coupled receptor that is a translation product of the human ADGRE1 gene or a 1:1 ortholog thereof." [PRO:DAN, PRO:WCB] comment: Category=gene. Requested by=CL. synonym: "ADGRE1" EXACT PRO-short-label [PRO:DNx] synonym: "cell surface glycoprotein F4/80" EXACT [] synonym: "EGF-like module receptor 1" EXACT [] synonym: "EGF-like module-containing mucin-like hormone receptor-like 1" EXACT [] synonym: "EMR1" RELATED Gene-based [PRO:DNx] synonym: "EMR1 hormone receptor" EXACT [] synonym: "Gpf480" RELATED Gene-based [] synonym: "TM7LN3" RELATED Gene-based [] xref: IUPHARobj:182 xref: PIRSF:PIRSF038685 is_a: PR:000001087 ! adhesion G-protein coupled receptor [Term] id: PR:000001820 name: MHC class II histocompatibility antigen alpha chain namespace: protein def: "A protein with core architecture consisting of a signal sequence, a Class II histocompatibility antigen, alpha domain (Pfam:PF00993) and an Immunoglobulin C1-set domain (Pfam:PF07654); these form the extracellular domain and are followed by a single-pass transmembrane region and a small cytoplasmic region." [PRO:WCB, Wikipedia:Human_leukocyte_antigen] comment: Category=family. Note: There are three major and two minor class II MHC (major histocompatability complex) alpha chain genes in human. Designations for the MHC complex loci are species specific: HLA (human leukocyte antigen) in human, H-2 in mouse. MHC class II loci are characterized by large numbers of allelic variants. In contrast to MHC Class I alpha chain genes, orthologies can be seen between some human and mouse genes. MHC class II alpha chains form heterodimers with MHLC class II beta chains. synonym: "MHCcIIalpha" EXACT PRO-short-label [PRO:DAN] is_a: PR:000000001 ! protein [Term] id: PR:000001832 name: SIRP/SHPS-1 family protein namespace: protein def: "A protein with core architecture consisting of a signal sequence, one Immunoglobulin V-set domain (Pfam:PF07686), two Immunoglobulin C1-set domains (Pfam:PF07654), a single-pass transmembrane region and a very small cytoplasmic region." [PRO:WCB] comment: Category=family. xref: PIRSF:PIRSF038063 is_a: PR:000000001 ! protein [Term] id: PR:000001833 name: SLAM family member 1 namespace: protein def: "A protein that is a translation product of the human SLAMF1 gene or a 1:1 ortholog thereof." [PRO:WCB] comment: Category=gene. Requested by=CL. synonym: "CD150" EXACT [] synonym: "CDw150" EXACT [] synonym: "IPO-3" EXACT [] synonym: "SLAM" RELATED Gene-based [] synonym: "SLAMF1" EXACT PRO-short-label [PRO:DNx] is_a: PR:000000001 ! protein [Term] id: PR:000001835 name: T-box transcription factor TBX21 namespace: protein def: "A protein that is a translation product of the human TBX21 gene or a 1:1 ortholog thereof." [PRO:WCB] comment: Category=gene. Requested by=CL. synonym: "T-box protein 21" EXACT [] synonym: "T-cell-specific T-box transcription factor T-bet" EXACT [] synonym: "TBET" RELATED Gene-based [] synonym: "TBLYM" RELATED Gene-based [] synonym: "TBX21" EXACT PRO-short-label [PRO:DNx] synonym: "transcription factor TBLYM" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000001836 name: CD7 molecule namespace: protein def: "A protein that is a translation product of the human CD7 gene or a 1:1 ortholog thereof." [PRO:WCB] comment: Category=gene. Requested by=CL. synonym: "CD7" EXACT PRO-short-label [PRO:DNx] synonym: "GP40" EXACT [] synonym: "T-cell antigen CD7" EXACT [] synonym: "T-cell leukemia antigen" EXACT [] synonym: "T-cell surface antigen Leu-9" EXACT [] synonym: "TP41" EXACT [] xref: PIRSF:PIRSF038791 is_a: PR:000000001 ! protein [Term] id: PR:000001838 name: T-cell surface glycoprotein CD1 namespace: protein def: "A protein with core architecture consisting of a signal sequence, an extracellular region with Class I Histocompatibility antigen, domains alpha 1 and alpha two (Pfam:PF00129) and an Immunoglobulin C1-set domain (Pfam:PF07654), a single-pass transmembrane region, and a very short cytoplasmic region. Forms a heterodimer with beta-2 microglobulin." [PRO:WCB] comment: Category=family. synonym: "CD1" EXACT PRO-short-label [PRO:DAN] xref: PIRSF:PIRSF038798 is_a: PR:000000001 ! protein [Term] id: PR:000001839 name: T-cell surface glycoprotein CD5 namespace: protein def: "A protein that is a translation product of the human CD5 gene or a 1:1 ortholog thereof." [PRO:WCB] comment: Category=gene. Requested by=CL. synonym: "CD5" EXACT PRO-short-label [PRO:DNx] synonym: "LEU1" RELATED Gene-based [] synonym: "ly-1" EXACT [] synonym: "lymphocyte antigen 1" EXACT [] synonym: "lymphocyte antigen T1/Leu-1" EXACT [] synonym: "Lyt-1" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000001841 name: T-cell-specific surface glycoprotein CD28 namespace: protein def: "A protein that is a translation product of the human CD28 gene or a 1:1 ortholog thereof." [PRO:WCB] comment: Category=gene. Requested by=CL. synonym: "CD28" EXACT PRO-short-label [PRO:DNx] synonym: "TP44" EXACT [] xref: IUPHARobj:2863 is_a: PR:000000001 ! protein [Term] id: PR:000001843 name: Thy-1 membrane glycoprotein namespace: protein def: "A protein that is a translation product of the human THY1 gene or a 1:1 ortholog thereof." [PRO:WCB] comment: Category=gene. Requested by=CL. synonym: "CD90" EXACT [] synonym: "CDw90" EXACT [] synonym: "Thy-1" RELATED Gene-based [] synonym: "Thy-1 antigen" EXACT [] synonym: "THY1" EXACT PRO-short-label [PRO:DNx] xref: PIRSF:PIRSF038777 is_a: PR:000000001 ! protein [Term] id: PR:000001844 name: arginase-1 namespace: protein def: "A protein that is a translation product of the human ARG1 gene or a 1:1 ortholog thereof." [PRO:WCB] comment: Category=gene. Requested by=CL. synonym: "ARG1" EXACT PRO-short-label [PRO:DNx] synonym: "liver-type arginase" EXACT [] synonym: "type I arginase" EXACT [] xref: IUPHARobj:1244 is_a: PR:000000001 ! protein [Term] id: PR:000001850 name: cathepsin K namespace: protein def: "A cathepsin-like protease that is a translation product of the human CTSK gene or a 1:1 ortholog thereof." [PRO:DAN, PRO:WCB] comment: Category=gene. Requested by=CL. synonym: "cathepsin O" RELATED [] synonym: "cathepsin O2" EXACT [] synonym: "cathepsin X" RELATED [] synonym: "CTSK" EXACT PRO-short-label [PRO:DNx] synonym: "CTSO" RELATED Gene-based [] synonym: "CTSO2" RELATED Gene-based [] xref: IUPHARobj:2350 is_a: PR:000040662 ! cathepsin-like protease [Term] id: PR:000001852 name: cytotoxic T-lymphocyte protein 4 namespace: protein def: "A protein that is a translation product of the human CTLA4 gene or a 1:1 ortholog thereof." [PRO:WCB] comment: Category=gene. Requested by=CL. synonym: "CD152" RELATED Gene-based [] synonym: "CTLA-4" EXACT [] synonym: "CTLA4" EXACT PRO-short-label [PRO:DNx] synonym: "cytotoxic T-lymphocyte-associated antigen 4" EXACT [] xref: IUPHARobj:2743 is_a: PR:000000001 ! protein [Term] id: PR:000001854 name: ectonucleoside triphosphate diphosphohydrolase 1 namespace: protein def: "A protein that is a translation product of the human ENTPD1 gene or a 1:1 ortholog thereof." [PRO:WCB] comment: Category=gene. synonym: "ATP diphosphohydrolase" EXACT [] synonym: "ATP-DPH" EXACT [] synonym: "ATPDase" EXACT [] synonym: "CD39" RELATED Gene-based [] synonym: "ecto-apyrase" EXACT [] synonym: "ecto-ATP diphosphohydrolase 1" EXACT [] synonym: "ecto-ATPase 1" EXACT [] synonym: "ecto-ATPDase 1" EXACT [] synonym: "ENTPD1" EXACT PRO-short-label [PRO:DNx] synonym: "lymphoid cell activation antigen" EXACT [] synonym: "NTPDase 1" EXACT [] synonym: "NTPDase1" EXACT [] synonym: "nucleoside triphosphate diphosphohydrolase 1" EXACT [] xref: IUPHARobj:2888 is_a: PR:000000001 ! protein [Term] id: PR:000001858 name: immunoglobulin iota chain namespace: protein def: "A protein that is a translation product of the human VPREB1 gene or a 1:1 ortholog thereof. The gene is recently and independently duplicated in mouse and rabbit, giving rise to very closely related VPREB2 genes in those species. The protein associates with the Ig-mu chain to form a molecular complex that is expressed only on the surface of pre-B-cells." [PRO:WCB] comment: Category=gene. Requested by=CL. synonym: "CD179 antigen-like family member A" EXACT [] synonym: "CD179a" EXACT [] synonym: "protein VPreB1" EXACT [] synonym: "V(pre)B protein" EXACT [] synonym: "VPREB" RELATED Gene-based [] synonym: "VpreB protein" EXACT [] synonym: "VPREB1" EXACT PRO-short-label [PRO:DNx] xref: PIRSF:PIRSF038787 is_a: PR:000000001 ! protein [Term] id: PR:000001859 name: immunoglobulin lambda-like polypeptide 1 namespace: protein def: "A protein that is a translation product of the human IGLL1 gene or a 1:1 ortholog thereof." [PRO:WCB] comment: Category=gene. Requested by=CL. synonym: "CD179 antigen-like family member B" EXACT [] synonym: "CD179b" EXACT [] synonym: "Ig lambda-5" EXACT [] synonym: "Igl-5" RELATED [] synonym: "IGL1" RELATED Gene-based [] synonym: "IGLL1" EXACT PRO-short-label [PRO:DNx] synonym: "immunoglobulin omega polypeptide" EXACT [] synonym: "immunoglobulin-related protein 14.1" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000001860 name: inducible T-cell costimulator namespace: protein def: "A protein that is a translation product of the human ICOS gene or a 1:1 ortholog thereof." [PRO:WCB] comment: Category=gene. Requested by=CL. synonym: "activation-inducible lymphocyte immunomediatory molecule" EXACT [] synonym: "AILIM" RELATED Gene-based [] synonym: "CCLP" EXACT [] synonym: "CD278" EXACT [] synonym: "CD28 and CTLA-4-like protein" EXACT [] synonym: "CD28-related protein 1" EXACT [] synonym: "CRP-1" RELATED [] synonym: "ICOS" EXACT PRO-short-label [PRO:DNx] xref: IUPHARobj:2939 is_a: PR:000000001 ! protein [Term] id: PR:000001861 name: integrin beta namespace: protein def: "A protein with core architecture consisting of a large extracellular region containing one Integrin, beta chain domain (Pfam:PF00362), up to four EGF-like domains (Pfam:PF07974), and an Integrin beta tail domain (Pfam:PF07965), followed by a single-pass transmembrane region and a small cytoplasmic region often containing an Integrin beta cytoplasmic domain (Pfam:PF08725)." [PRO:WCB] comment: Category=family. xref: PIRSF:PIRSF002512 is_a: PR:000000001 ! protein [Term] id: PR:000001865 name: interleukin-3 receptor class 2 alpha chain namespace: protein def: "A protein that is a translation product of the human IL3RA gene or a 1:1 ortholog thereof." [PRO:WCB] comment: Category=gene. Requested by=CL. synonym: "CD123" EXACT [] synonym: "IL-3 receptor subunit alpha" EXACT [] synonym: "IL-3R subunit alpha" EXACT [] synonym: "IL-3R-alpha" EXACT [] synonym: "IL-3RA" EXACT [] synonym: "IL3R" RELATED Gene-based [] synonym: "IL3RA" EXACT PRO-short-label [PRO:DNx] synonym: "interleukin-3 receptor class II alpha chain" EXACT [] synonym: "Sut-1" RELATED Gene-based [] xref: IUPHARobj:1705 is_a: PR:000000001 ! protein [Term] id: PR:000001867 name: interleukin-5 receptor subunit alpha namespace: protein def: "A protein that is a translation product of the human IL5RA gene or a 1:1 ortholog thereof." [PRO:WCB] comment: Category=gene. Requested by=CL. synonym: "CD125" EXACT [] synonym: "CDw125" EXACT [] synonym: "IL-5 receptor subunit alpha" EXACT [] synonym: "IL-5R subunit alpha" EXACT [] synonym: "IL-5R-alpha" EXACT [] synonym: "IL-5RA" EXACT [] synonym: "IL5R" RELATED Gene-based [] synonym: "IL5RA" EXACT PRO-short-label [PRO:DNx] xref: IUPHARobj:1706 xref: PIRSF:PIRSF018419 is_a: PR:000000001 ! protein [Term] id: PR:000001869 name: interleukin-7 receptor subunit alpha namespace: protein def: "A protein that is a translation product of the human IL7R gene or a 1:1 ortholog thereof." [PRO:WCB] comment: Category=gene. Requested by=CL. synonym: "CD127" EXACT [] synonym: "CDw127" EXACT [] synonym: "IL-7 receptor subunit alpha" EXACT [] synonym: "IL-7R subunit alpha" EXACT [] synonym: "IL-7R-alpha" EXACT [] synonym: "IL-7RA" EXACT [] synonym: "IL7R" EXACT PRO-short-label [PRO:DNx] xref: IUPHARobj:1698 xref: PIRSF:PIRSF001960 is_a: PR:000000001 ! protein [Term] id: PR:000001874 name: KLRB1-like protein namespace: protein def: "A protein that is a translation product of the KLRB1 gene or its closely related paralogs (KLRB1A-F). There are lineage-specific expansions in mouse and rat." [PRO:WCB] comment: Category=family. Requested by=CL. xref: PIRSF:PIRSF038804 is_a: PR:000000001 ! protein [Term] id: PR:000001879 name: leukosialin namespace: protein def: "A protein that is a translation product of the human SPN gene or a 1:1 ortholog thereof." [PRO:WCB] comment: Category=gene. Requested by=CL. synonym: "B-cell differentiation antigen LP-3" EXACT [] synonym: "CD43" RELATED Gene-based [] synonym: "galactoglycoprotein" EXACT [] synonym: "GALGP" EXACT [] synonym: "leukocyte sialoglycoprotein" EXACT [] synonym: "ly-48" EXACT [] synonym: "lymphocyte antigen 48" EXACT [] synonym: "sialophorin" EXACT [] synonym: "SPN" EXACT PRO-short-label [PRO:DNx] xref: PIRSF:PIRSF001994 is_a: PR:000000001 ! protein [Term] id: PR:000001880 name: low affinity immunoglobulin epsilon Fc receptor namespace: protein def: "A protein that is a translation product of the human FCER2 gene or a 1:1 ortholog thereof." [PRO:WCB] comment: Category=gene. Requested by=CL. synonym: "BLAST-2" EXACT [] synonym: "C-type lectin domain family 4 member J" EXACT [] synonym: "CD23" EXACT [] synonym: "CD23A" RELATED Gene-based [] synonym: "CLEC4J" RELATED Gene-based [] synonym: "Fc-epsilon-RII" EXACT [] synonym: "FCE2" RELATED Gene-based [] synonym: "FCER2" EXACT PRO-short-label [PRO:DNx] synonym: "Fcer2a" RELATED Gene-based [] synonym: "IGEBF" RELATED Gene-based [] synonym: "immunoglobulin E-binding factor" EXACT [] synonym: "lymphocyte IgE receptor" EXACT [] xref: IUPHARobj:2935 xref: PIRSF:PIRSF002426 is_a: PR:000000001 ! protein [Term] id: PR:000001883 name: lysosome-associated membrane protein namespace: protein def: "A protein with core architecture consisting of a Lysosome-associated membrane glycoprotein (Pfam:PF01299) domain. It is a single-pass type I membrane protein that shuttles between lysosomes, endosomes, and the plasma membrane." [PRO:WCB] comment: Category=family. xref: PIRSF:PIRSF002462 is_a: PR:000000001 ! protein [Term] id: PR:000001884 name: macrophage receptor MARCO namespace: protein def: "A protein that is a translation product of the human MARCO gene or a 1:1 ortholog thereof." [PRO:WCB] comment: Category=gene. Requested by=CL. synonym: "macrophage receptor with collagenous structure" EXACT [] synonym: "MARCO" EXACT PRO-short-label [PRO:DNx] synonym: "SCARA2" RELATED Gene-based [] synonym: "scavenger receptor class A member 2" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000001885 name: macrophage scavenger receptor types I and II namespace: protein def: "A protein that is a translation product of the human MSR1 gene or a 1:1 ortholog thereof." [PRO:WCB] comment: Category=gene. Requested by=CL. synonym: "CD204" EXACT [] synonym: "macrophage acetylated LDL receptor I and II" EXACT [] synonym: "MSR1" EXACT PRO-short-label [PRO:DNx] synonym: "SCARA1" RELATED Gene-based [] synonym: "scavenger receptor class A member 1" EXACT [] synonym: "scavenger receptor type A" EXACT [] synonym: "Scvr" RELATED Gene-based [] synonym: "SR-A" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000001888 name: membrane alanyl aminopeptidase-like metallopeptidase namespace: protein def: "A protein with core architecture consisting of a Peptidase family M1 domain (Pfam:PF01433)." [PRO:WCB] comment: Category=family. xref: PIRSF:PIRSF005502 is_a: PR:000000001 ! protein [Term] id: PR:000001889 name: CD14 molecule namespace: protein def: "A protein that is a translation product of the human CD14 gene or a 1:1 ortholog thereof." [PRO:WCB] comment: Category=gene. Requested by=CL. synonym: "CD14" EXACT PRO-short-label [PRO:DNx] synonym: "monocyte differentiation antigen CD14" EXACT [] synonym: "myeloid cell-specific leucine-rich glycoprotein" EXACT [] xref: PIRSF:PIRSF002017 is_a: PR:000000001 ! protein [Term] id: PR:000001892 name: CD33 molecule namespace: protein def: "A protein that is a translation product of the human CD33 gene or a 1:1 ortholog thereof." [PRO:WCB] comment: Category=gene. Requested by=CL. synonym: "CD33" EXACT PRO-short-label [PRO:DNx] synonym: "gp67" EXACT [] synonym: "myeloid cell surface antigen CD33" EXACT [] synonym: "sialic acid-binding Ig-like lectin 3" EXACT [] synonym: "siglec-3" EXACT [] synonym: "SIGLEC3" RELATED Gene-based [] xref: IUPHARobj:2601 is_a: PR:000000001 ! protein [Term] id: PR:000001893 name: natural cytotoxicity triggering receptor 1 namespace: protein def: "A protein that is a translation product of the human NCR1 gene or a 1:1 ortholog thereof." [PRO:WCB] comment: Category=gene. Requested by=CL. synonym: "activating receptor 1" EXACT [] synonym: "AR-1" EXACT [] synonym: "CD335" EXACT [] synonym: "LY94" RELATED Gene-based [] synonym: "lymphocyte antigen 94" EXACT [] synonym: "lymphocyte antigen 94 homolog" EXACT [] synonym: "natural killer cell p46-related protein" EXACT [] synonym: "NCR1" EXACT PRO-short-label [PRO:DNx] synonym: "NK cell-activating receptor" BROAD [PRO:DNx] synonym: "NK-p46" EXACT [] synonym: "NKp46" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000001894 name: natural cytotoxicity triggering receptor 2 namespace: protein def: "A protein that is a translation product of the human NCR2 gene or a 1:1 ortholog thereof." [PRO:WCB] comment: Category=gene. Not found in mouse. synonym: "CD336" EXACT [] synonym: "LY95" RELATED Gene-based [] synonym: "lymphocyte antigen 95 homolog" EXACT [] synonym: "natural killer cell p44-related protein" EXACT [] synonym: "NCR2" EXACT PRO-short-label [PRO:DNx] synonym: "NK cell-activating receptor" BROAD [PRO:DNx] synonym: "NK-p44" EXACT [] synonym: "NKp44" EXACT [] xref: PIRSF:PIRSF037963 is_a: PR:000000001 ! protein [Term] id: PR:000001896 name: natural killer cell receptor 2B4 namespace: protein def: "A protein that is a translation product of the human CD244 gene or a 1:1 ortholog thereof." [PRO:WCB] comment: Category=gene. Requested by=CL. synonym: "2B4" RELATED Gene-based [] synonym: "CD244" EXACT PRO-short-label [PRO:DNx] synonym: "NAIL" EXACT [] synonym: "NK cell activation-inducing ligand" EXACT [] synonym: "NK cell type I receptor protein 2B4" EXACT [] synonym: "NKR2B4" EXACT [] synonym: "Nmrk" RELATED Gene-based [] synonym: "non-MHC restricted killing associated" EXACT [] synonym: "signaling lymphocytic activation molecule 4" EXACT [] synonym: "SLAM family member 4" EXACT [] synonym: "SLAMF4" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000001897 name: natural killer cell receptor NKG2 namespace: protein def: "A protein with core architecture consisting of an as yet unnamed domain in the amino-terminal half and a carboxyl-terminal Lectin C-type domain (Pfam:PF00059)." [PRO:WCB] comment: Category=family. xref: PIRSF:PIRSF005558 is_a: PR:000000001 ! protein [Term] id: PR:000001898 name: neprilysin namespace: protein def: "A protein that is a translation product of the human MME gene or a 1:1 ortholog thereof." [PRO:WCB] comment: Category=gene. Requested by=CL. synonym: "atriopeptidase" EXACT [] synonym: "CALLA" EXACT [] synonym: "CD10" EXACT [] synonym: "common acute lymphocytic leukemia antigen" EXACT [] synonym: "enkephalinase" EXACT [] synonym: "EPN" RELATED Gene-based [] synonym: "MME" EXACT PRO-short-label [PRO:DNx] synonym: "NEP" EXACT [] synonym: "neutral endopeptidase" EXACT [] synonym: "neutral endopeptidase 24.11" EXACT [] synonym: "SFE" EXACT [] synonym: "skin fibroblast elastase" EXACT [] xref: IUPHARobj:1611 xref: PIRSF:PIRSF501074 is_a: PR:000000001 ! protein [Term] id: PR:000001902 name: nuclear receptor ROR-gamma namespace: protein def: "A protein that is a translation product of the human RORC gene or a 1:1 ortholog thereof." [PRO:WCB] comment: Category=gene. synonym: "NR1F3" RELATED Gene-based [] synonym: "nuclear receptor RZR-gamma" EXACT [] synonym: "nuclear receptor subfamily 1 group F member 3" EXACT [] synonym: "RAR-related orphan receptor C" EXACT [] synonym: "retinoid-related orphan receptor-gamma" EXACT [] synonym: "RORC" EXACT PRO-short-label [PRO:DNx] synonym: "RORG" RELATED Gene-based [] synonym: "RZRG" RELATED Gene-based [] synonym: "Thor" RELATED Gene-based [] synonym: "thymus orphan receptor" EXACT [] synonym: "TOR" EXACT [] xref: IUPHARobj:600 is_a: PR:000000001 ! protein [Term] id: PR:000001903 name: paired box protein PAX-5 namespace: protein def: "A protein that is a translation product of the human PAX5 gene or a 1:1 ortholog thereof." [PRO:WCB] comment: Category=gene. Requested by=CL. synonym: "B-cell-specific transcription factor" EXACT [] synonym: "BSAP" EXACT [] synonym: "Pax-5" RELATED Gene-based [] synonym: "PAX5" EXACT PRO-short-label [PRO:DNx] is_a: PR:000000001 ! protein [Term] id: PR:000001905 name: platelet glycoprotein 4 namespace: protein def: "A protein that is a translation product of the human CD36 gene or a 1:1 ortholog thereof." [PRO:WCB] comment: Category=gene. Requested by=CL. synonym: "CD36" EXACT PRO-short-label [PRO:DNx] synonym: "FAT" EXACT [] synonym: "fatty acid translocase" EXACT [] synonym: "glycoprotein IIIb" EXACT [] synonym: "GP3B" RELATED Gene-based [] synonym: "GP4" RELATED Gene-based [] synonym: "GPIIIB" EXACT [] synonym: "GPIV" EXACT [] synonym: "leukocyte differentiation antigen CD36" EXACT [] synonym: "PAS IV" EXACT [] synonym: "PAS-4" EXACT [] synonym: "platelet collagen receptor" EXACT [] synonym: "platelet glycoprotein IV" EXACT [] synonym: "thrombospondin receptor" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000001907 name: platelet glycoprotein Ib alpha chain namespace: protein def: "A protein that is a translation product of the human GP1BA gene or a 1:1 ortholog thereof." [PRO:WCB] comment: Category=gene. Requested by=CL. synonym: "antigen CD42b-alpha" EXACT [] synonym: "CD42b" EXACT [] synonym: "glycoprotein Ibalpha" EXACT [] synonym: "GP-Ib alpha" EXACT [] synonym: "GP1BA" EXACT PRO-short-label [PRO:DNx] synonym: "GPIb-alpha" EXACT [] synonym: "GPIbA" EXACT [] xref: PIRSF:PIRSF002493 is_a: PR:000000001 ! protein [Term] id: PR:000001919 name: programmed cell death protein 1 namespace: protein def: "A protein that is a translation product of the human PDCD1 gene or a 1:1 ortholog thereof." [PRO:WCB] comment: Category=gene. Requested by=CL. synonym: "CD279" EXACT [] synonym: "PD-1" EXACT [] synonym: "PD1" RELATED Gene-based [] synonym: "PDCD1" EXACT PRO-short-label [PRO:DNx] synonym: "protein PD-1" EXACT [] xref: IUPHARobj:2760 xref: PIRSF:PIRSF018380 is_a: PR:000000001 ! protein [Term] id: PR:000001925 name: scavenger receptor cysteine-rich type 1 protein M130 namespace: protein def: "A protein that is a translation product of the human CD163 gene or a 1:1 ortholog thereof." [PRO:WCB] comment: Category=gene. Requested by=CL. synonym: "CD163" EXACT PRO-short-label [PRO:DNx] synonym: "hemoglobin scavenger receptor" EXACT [] synonym: "M130" RELATED Gene-based [] is_a: PR:000000001 ! protein [Term] id: PR:000001927 name: sialic acid-binding Ig-like lectin 5 namespace: protein def: "A protein that is a translation product of the human SIGLEC5 gene or a 1:1 ortholog thereof." [PRO:WCB] comment: Category=gene. Requested by=CL. synonym: "CD170" EXACT [] synonym: "CD33 antigen-like 2" EXACT [] synonym: "CD33L2" RELATED Gene-based [] synonym: "OB-binding protein 2" EXACT [] synonym: "OB-BP2" EXACT [] synonym: "OBBP2" RELATED Gene-based [] synonym: "obesity-binding protein 2" EXACT [] synonym: "sialic acid-binding Ig-like lectin F" EXACT [] synonym: "siglec-5" EXACT [] synonym: "siglec-F" EXACT [] synonym: "SIGLEC5" EXACT PRO-short-label [PRO:DNx] synonym: "Siglecf" RELATED [] is_a: PR:000000001 ! protein [Term] id: PR:000001928 name: sialic acid-binding Ig-like lectin 6 namespace: protein def: "A protein that is a translation product of the human SIGLEC6 gene or a 1:1 ortholog thereof." [PRO:WCB] comment: Category=gene. There is no mouse ortholog. synonym: "CD327" EXACT [] synonym: "CD33 antigen-like 1" EXACT [] synonym: "CD33L" RELATED Gene-based [] synonym: "CD33L1" RELATED Gene-based [] synonym: "CDw327" EXACT [] synonym: "OB-BP1" EXACT [] synonym: "OBBP1" RELATED Gene-based [] synonym: "obesity-binding protein 1" EXACT [] synonym: "siglec-6" EXACT [] synonym: "SIGLEC6" EXACT PRO-short-label [PRO:DNx] is_a: PR:000000001 ! protein [Term] id: PR:000001931 name: sialoadhesin namespace: protein def: "A protein that is a translation product of the human SIGLEC1 gene or a 1:1 ortholog thereof." [PRO:WCB] comment: Category=gene. Requested by=CL. synonym: "CD169" EXACT [] synonym: "Sa" RELATED Gene-based [] synonym: "SER" EXACT [] synonym: "sheep erythrocyte receptor" EXACT [] synonym: "sialic acid-binding Ig-like lectin 1" EXACT [] synonym: "siglec-1" EXACT [] synonym: "SIGLEC1" EXACT PRO-short-label [PRO:DNx] synonym: "SN" RELATED Gene-based [] is_a: PR:000000001 ! protein [Term] id: PR:000001932 name: signal transducer CD24 namespace: protein def: "A protein that is a translation product of the human CD24 gene or a 1:1 ortholog thereof." [PRO:WCB] comment: Category=gene. The mouse ortholog is Cd24a. Mouse protein Cd24b likely also orthologous. Currently it is not in UniProt. Requested by=CL. synonym: "CD24" EXACT PRO-short-label [PRO:DNx] synonym: "CD24A" RELATED Gene-based [] synonym: "HSA" EXACT [] synonym: "ly-52" EXACT [] synonym: "lymphocyte antigen 52" EXACT [] synonym: "M1/69-J11D heat stable antigen" EXACT [] synonym: "nectadrin" EXACT [] synonym: "R13-Ag" EXACT [] synonym: "small cell lung carcinoma cluster 4 antigen" EXACT [] synonym: "X62 heat stable antigen" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000001935 name: syndecan-1 namespace: protein def: "A protein that is a translation product of the human SDC1 gene or a 1:1 ortholog thereof." [PRO:WCB] comment: Category=gene. Requested by=CL. synonym: "CD138" EXACT [] synonym: "SDC" RELATED Gene-based [] synonym: "SDC1" EXACT PRO-short-label [PRO:DNx] synonym: "Synd-1" RELATED Gene-based [] synonym: "SYND1" EXACT [] xref: PIRSF:PIRSF015854 is_a: PR:000000001 ! protein [Term] id: PR:000001937 name: tartrate-resistant acid phosphatase type 5 namespace: protein def: "A protein that is a translation product of the human ACP5 gene or a 1:1 ortholog thereof." [PRO:WCB] comment: Category=gene. Requested by=CL. synonym: "ACP5" EXACT PRO-short-label [PRO:DNx] synonym: "T5ap" RELATED Gene-based [] synonym: "tartrate-resistant acid ATPase" EXACT [] synonym: "TR-AP" EXACT [] synonym: "Trap" RELATED Gene-based [] synonym: "TrATPase" EXACT [] synonym: "type 5 acid phosphatase" EXACT [] xref: PIRSF:PIRSF000898 is_a: PR:000000001 ! protein [Term] id: PR:000001938 name: thrombomodulin-like receptor namespace: protein def: "A protein with core architecture consisting of a signal sequence, a Lectin C-type domain (Pfam:PF00059), 5 or 6 EGF-like domains (Pfam:PF00008, Pfam:PF09064, or Pfam:PF07645), a transmembrane region, and a small cytoplasmic region (36-51 amino acids)." [PRO:WCB] comment: Category=family. xref: PIRSF:PIRSF001775 is_a: PR:000000001 ! protein [Term] id: PR:000001941 name: trans-acting T-cell-specific transcription factor GATA-3 namespace: protein def: "A protein that is a translation product of the human GATA3 gene or a 1:1 ortholog thereof." [PRO:WCB] comment: Category=gene. Requested by=CL. synonym: "Gata-3" RELATED Gene-based [] synonym: "GATA-binding factor 3" EXACT [] synonym: "GATA3" EXACT PRO-short-label [PRO:DNx] is_a: PR:000000001 ! protein [Term] id: PR:000001944 name: transcription factor PU.1 namespace: protein def: "A protein that is a translation product of the human SPI1 gene or a 1:1 ortholog thereof." [PRO:WCB] comment: Category=gene. Requested by=CL. synonym: "31 kDa-transforming protein" EXACT [] synonym: "SFFV proviral integration 1 protein" EXACT [] synonym: "Sfpi-1" RELATED Gene-based [] synonym: "Sfpi1" RELATED Gene-based [] synonym: "SPI1" EXACT PRO-short-label [PRO:DNx] is_a: PR:000000001 ! protein [Term] id: PR:000001945 name: transferrin receptor protein 1 namespace: protein def: "A protein that is a translation product of the human TFRC gene or a 1:1 ortholog thereof." [PRO:WCB] comment: Category=gene. Requested by=CL. synonym: "CD71" EXACT [] synonym: "p90" BROAD [PRO:DNx] synonym: "T9" EXACT [] synonym: "TfR" EXACT [] synonym: "TfR1" EXACT [] synonym: "TFRC" EXACT PRO-short-label [PRO:DNx] synonym: "TR" RELATED [] synonym: "Trfr" RELATED Gene-based [] is_a: PR:000000001 ! protein [Term] id: PR:000001950 name: tumor necrosis factor ligand superfamily member 5 namespace: protein def: "A protein that is a translation product of the human CD40LG gene or a 1:1 ortholog thereof." [PRO:WCB] comment: Category=gene. Requested by=CL. synonym: "CD154" EXACT [] synonym: "CD40-L" EXACT [] synonym: "CD40L" RELATED Gene-based [] synonym: "CD40LG" EXACT PRO-short-label [PRO:DNx] synonym: "T-cell antigen Gp39" EXACT [] synonym: "TNF-related activation protein" EXACT [] synonym: "TNFSF5" RELATED Gene-based [] synonym: "TRAP" BROAD Gene-based [PRO:DNx] xref: PIRSF:PIRSF016527 is_a: PR:000000001 ! protein [Term] id: PR:000001954 name: tumor necrosis factor receptor superfamily member 11A namespace: protein def: "A protein that is a translation product of the human TNFRSF11A gene or a 1:1 ortholog thereof." [PRO:WCB] comment: Category=gene. Requested by=CL. synonym: "CD265" EXACT [] synonym: "ODFR" EXACT [] synonym: "osteoclast differentiation factor receptor" EXACT [] synonym: "RANK" RELATED Gene-based [] synonym: "receptor activator of NF-KB" EXACT [] synonym: "TNFRSF11A" EXACT PRO-short-label [PRO:DNx] xref: IUPHARobj:1881 xref: PIRSF:PIRSF038806 is_a: PR:000000001 ! protein [Term] id: PR:000001963 name: CD27 molecule namespace: protein def: "A protein that is a translation product of the human CD27 gene or a 1:1 ortholog thereof." [PRO:WCB] comment: Category=gene. Requested by=CL. synonym: "CD27" EXACT PRO-short-label [PRO:DNx] synonym: "CD27L receptor" EXACT [] synonym: "T-cell activation antigen CD27" EXACT [] synonym: "T14" RELATED [] synonym: "TNFRSF7" RELATED Gene-based [] synonym: "tumor necrosis factor receptor superfamily member 7" EXACT [] xref: IUPHARobj:1876 xref: PIRSF:PIRSF001966 is_a: PR:000000001 ! protein [Term] id: PR:000001968 name: tyrosine-protein phosphatase non-receptor type substrate 1 namespace: protein def: "A SIRP/SHPS-1 family protein that is a translation product of the human SIRPA gene or a 1:1 ortholog thereof." [PRO:WCB] comment: Category=gene. Requested by=CL. synonym: "BIT" RELATED Gene-based [] synonym: "Bit" EXACT [] synonym: "brain Ig-like molecule with tyrosine-based activation motifs" EXACT [] synonym: "CD172 antigen-like family member A" EXACT [] synonym: "CD172a" EXACT [] synonym: "inhibitory receptor SHPS-1" EXACT [] synonym: "macrophage fusion receptor" EXACT [] synonym: "MFR" RELATED Gene-based [] synonym: "MyD-1 antigen" EXACT [] synonym: "MYD1" RELATED Gene-based [] synonym: "p84" BROAD [PRO:DNx] synonym: "PTPNS1" RELATED Gene-based [] synonym: "SHP substrate 1" EXACT [] synonym: "SHPS-1" EXACT [] synonym: "SHPS1" RELATED Gene-based [] synonym: "signal-regulatory protein alpha-1" EXACT [] synonym: "signal-regulatory protein alpha-2" EXACT [] synonym: "signal-regulatory protein alpha-3" EXACT [] synonym: "SIRP" RELATED Gene-based [] synonym: "Sirp-alpha-1" EXACT [] synonym: "Sirp-alpha-2" EXACT [] synonym: "Sirp-alpha-3" EXACT [] synonym: "SIRPA" EXACT PRO-short-label [PRO:DNx] xref: IUPHARobj:2942 is_a: PR:000001832 ! SIRP/SHPS-1 family protein [Term] id: PR:000001969 name: urokinase plasminogen activator surface receptor namespace: protein def: "A protein that is a translation product of the human PLAUR gene or a 1:1 ortholog thereof." [PRO:WCB] comment: Category=gene. Requested by=CL. synonym: "CD87" EXACT [] synonym: "MO3" RELATED Gene-based [] synonym: "monocyte activation antigen Mo3" EXACT [] synonym: "PLAUR" EXACT PRO-short-label [PRO:DNx] synonym: "U-PAR" EXACT [] synonym: "UPAR" RELATED Gene-based [] synonym: "uPAR" EXACT [] xref: PIRSF:PIRSF002022 is_a: PR:000000001 ! protein [Term] id: PR:000001971 name: vascular endothelial growth factor receptor namespace: protein def: "A protein with core architecture consisting of a signal sequence, followed by 7 Ig-like domains (Pfam:PF00047, Pfam:PF07679, or Pfam:PF07686), a transmembrane region, and a cytoplasmic Protein tyrosine kinase domain." [PRO:WCB] comment: Category=family. xref: PIRSF:PIRSF038502 is_a: CHEBI:36080 [Term] id: PR:000001975 name: voltage-gated sodium channel subunit alpha namespace: protein def: "A voltage-gated sodium channel protein that has a core architecture consisting of four similar domains (I-VI), each containing six transmembrane helices (S1-S6), with a pore loop between S5 and S6. The S4 segments contain positively charged amino acids at every third position and serve as voltage sensors. These large proteins (about 2000 amino acids) contain a unique Sodium ion transport-associated domain (Pfam:PF06512) located between two pairs of Ion transport protein domains (Pfam:PF00520). An IQ calmodulin-binding motif (Pfam:PF00612) may be found about 100 amino acids from the carboxyl end." [PRO:WCB] comment: Category=family. xref: PIRSF:PIRSF002448 is_a: PR:000044660 ! voltage-gated sodium channel protein [Term] id: PR:000001998 name: C-C motif chemokine 3/4 namespace: protein def: "A C/C-C motif small inducible chemokine that is a translation product of the CCL3, CCL3L1/CCL3L3, or CCL4 gene." [PRO:WCB] comment: Category=family. xref: PIRSF:PIRSF500569 is_a: PR:000001808 ! C/C-C motif small inducible chemokine [Term] id: PR:000002001 name: receptor-type tyrosine-protein kinase FLT3 namespace: protein def: "A CSF-1/PDGF receptor-type tyrosine-protein kinase that is a translation product of the human FLT3 gene or a 1:1 ortholog thereof." [PRO:WCB] comment: Category=gene. Requested by=CL. synonym: "CD135" RELATED Gene-based [] synonym: "fetal liver kinase 2" EXACT [] synonym: "FL cytokine receptor" EXACT [] synonym: "FLK-2" EXACT [] synonym: "FLK2" RELATED Gene-based [] synonym: "FLT-3" EXACT [] synonym: "FLT3" EXACT PRO-short-label [PRO:DNx] synonym: "Fms-like tyrosine kinase 3" EXACT [] synonym: "stem cell tyrosine kinase 1" EXACT [] synonym: "STK-1" RELATED [] synonym: "STK1" RELATED Gene-based [] synonym: "tyrosine-protein kinase FLT3" EXACT [] synonym: "tyrosine-protein kinase receptor flk-2" EXACT [] synonym: "tyrosine-protein kinase receptor FLT3" EXACT [] xref: IUPHARobj:1807 xref: PIRSF:PIRSF500949 is_a: PR:000001810 ! CSF-1/PDGF receptor-type tyrosine-protein kinase [Term] id: PR:000002015 name: MHC class II histocompatibility antigen alpha chain DRA namespace: protein def: "An MHC class II histocompatibility antigen alpha chain that is a translation product of the human HLA-DRA gene or a 1:1 ortholog thereof." [PRO:WCB] comment: Category=gene. The mouse ortholog is called H2-Ea. synonym: "H2-Ea" RELATED [] synonym: "H2-IE-alpha" EXACT [] synonym: "HLA-DRA" RELATED Gene-based [] synonym: "HLA-DRA1" RELATED Gene-based [] synonym: "MHC class II antigen DRA" EXACT [] synonym: "MHCcIIalpha_DRA" EXACT PRO-short-label [PRO:DAN] is_a: PR:000001820 ! MHC class II histocompatibility antigen alpha chain [Term] id: PR:000002023 name: NKG2-A/NKG2-B type II integral membrane protein namespace: protein def: "A natural killer cell receptor NKG2 that is a translation product of the human KLRC1 gene or a 1:1 ortholog thereof." [PRO:WCB] comment: Category=gene. Requested by=CL. synonym: "CD159 antigen-like family member A" EXACT [] synonym: "CD159a" EXACT [] synonym: "KLRC1" EXACT PRO-short-label [PRO:DNx] synonym: "NK cell receptor A" EXACT [] synonym: "NKG2-A/B-activating NK receptor" EXACT [] synonym: "NKG2A" RELATED Gene-based [] xref: IUPHARobj:2849 is_a: PR:000001897 ! natural killer cell receptor NKG2 [Term] id: PR:000002025 name: T-cell surface glycoprotein CD1a namespace: protein def: "A T-cell surface glycoprotein CD1 that is a translation product of the human CD1A gene or a 1:1 ortholog thereof." [PRO:WCB] comment: Category=gene. Requested by=CL. synonym: "CD1A" EXACT PRO-short-label [PRO:DNx] synonym: "CD1a" EXACT [] synonym: "T-cell surface antigen T6/Leu-6" EXACT [] synonym: "Ta1 thymocyte antigen" EXACT [] is_a: PR:000001838 ! T-cell surface glycoprotein CD1 [Term] id: PR:000002027 name: T-cell surface glycoprotein CD1c namespace: protein def: "A T-cell surface glycoprotein CD1 that is a translation product of the human CD1C gene or a 1:1 ortholog thereof." [PRO:WCB] comment: Category=gene. Requested by=CL. synonym: "CD1C" EXACT PRO-short-label [PRO:DNx] synonym: "CD1c" EXACT [] is_a: PR:000001838 ! T-cell surface glycoprotein CD1 [Term] id: PR:000002028 name: antigen-presenting glycoprotein CD1d namespace: protein def: "A T-cell surface glycoprotein CD1 that is a translation product of the human CD1D gene or a 1:1 ortholog thereof." [PRO:WCB] comment: Category=gene. Requested by=CL. synonym: "Cd1.1" RELATED Gene-based [] synonym: "CD1D" EXACT PRO-short-label [PRO:DNx] synonym: "CD1d" EXACT [] synonym: "CD1d.1" EXACT [] synonym: "Cd1d1" RELATED Gene-based [] synonym: "R3G1" EXACT [] synonym: "T-cell surface glycoprotein CD1d" EXACT [] is_a: PR:000001838 ! T-cell surface glycoprotein CD1 [Term] id: PR:000002030 name: alpha-type platelet-derived growth factor receptor namespace: protein def: "A CSF-1/PDGF receptor-type tyrosine-protein kinase that is a translation product of the human PDGFRA gene or a 1:1 ortholog thereof." [PRO:WCB] comment: Category=gene. synonym: "alpha platelet-derived growth factor receptor" EXACT [] synonym: "CD140 antigen-like family member A" EXACT [] synonym: "CD140a" EXACT [] synonym: "CD140a antigen" EXACT [] synonym: "PDGF-R-alpha" EXACT [] synonym: "PDGFR-alpha" EXACT [] synonym: "PDGFR2" RELATED Gene-based [] synonym: "PDGFRA" EXACT PRO-short-label [PRO:DNx] synonym: "platelet-derived growth factor alpha receptor" EXACT [] synonym: "RHEPDGFRA" RELATED Gene-based [] xref: IUPHARobj:1803 xref: PIRSF:PIRSF500950 is_a: PR:000001810 ! CSF-1/PDGF receptor-type tyrosine-protein kinase [Term] id: PR:000002031 name: aminopeptidase N namespace: protein def: "A membrane alanyl aminopeptidase-like metallopeptidase that is a translation product of the human ANPEP gene or a 1:1 ortholog thereof." [PRO:WCB] comment: Category=gene. Requested by=CL. synonym: "alanyl aminopeptidase" EXACT [] synonym: "aminopeptidase M" EXACT [] synonym: "ANPEP" EXACT PRO-short-label [PRO:DNx] synonym: "AP-M" EXACT [] synonym: "AP-N" EXACT [] synonym: "APN" RELATED Gene-based [] synonym: "CD13" RELATED Gene-based [] synonym: "gp150" EXACT [] synonym: "Lap-1" RELATED Gene-based [] synonym: "Lap1" RELATED Gene-based [] synonym: "membrane protein p161" EXACT [] synonym: "microsomal aminopeptidase" EXACT [] synonym: "myeloid plasma membrane glycoprotein CD13" EXACT [] synonym: "PEPN" RELATED Gene-based [] xref: IUPHARobj:1560 is_a: PR:000001888 ! membrane alanyl aminopeptidase-like metallopeptidase [Term] id: PR:000002037 name: complement component C1q receptor namespace: protein def: "A thrombomodulin-like receptor that is a translation product of the human CD93 gene or a 1:1 ortholog thereof." [PRO:WCB] comment: Category=gene. Requested by=CL. synonym: "Aa4" RELATED Gene-based [] synonym: "C1q/MBL/SPA receptor" EXACT [] synonym: "C1qR" EXACT [] synonym: "C1qR(p)" EXACT [] synonym: "C1QR1" RELATED Gene-based [] synonym: "C1qRp" EXACT [] synonym: "CD93" EXACT PRO-short-label [PRO:DNx] synonym: "CDw93" EXACT [] synonym: "cell surface antigen AA4" EXACT [] synonym: "complement component 1 q subcomponent receptor 1" EXACT [] synonym: "Ly-68" EXACT [] synonym: "Ly68" RELATED Gene-based [] synonym: "lymphocyte antigen 68" EXACT [] synonym: "matrix-remodeling-associated protein 4" EXACT [] synonym: "MXRA4" RELATED Gene-based [] is_a: PR:000001938 ! thrombomodulin-like receptor [Term] id: PR:000002039 name: glutamyl aminopeptidase namespace: protein def: "A membrane alanyl aminopeptidase-like metallopeptidase that is a translation product of the human ENPEP gene or a 1:1 ortholog thereof." [PRO:WCB] comment: Category=gene. Requested by=CL. synonym: "aminopeptidase A" EXACT [] synonym: "AP-A" EXACT [] synonym: "BP-1/6C3 antigen" EXACT [] synonym: "CD249" EXACT [] synonym: "differentiation antigen gp160" EXACT [] synonym: "EAP" RELATED [] synonym: "ENPEP" EXACT PRO-short-label [PRO:DNx] xref: IUPHARobj:1568 is_a: PR:000001888 ! membrane alanyl aminopeptidase-like metallopeptidase [Term] id: PR:000002062 name: macrophage colony-stimulating factor 1 receptor namespace: protein def: "A CSF-1/PDGF receptor-type tyrosine-protein kinase that is a translation product of the human CSF1R gene or a 1:1 ortholog thereof." [PRO:WCB] comment: Category=gene. Requested by=CL. synonym: "CD115" EXACT [] synonym: "CSF-1 receptor" EXACT [] synonym: "CSF-1-R" EXACT [] synonym: "CSF-1R" EXACT [] synonym: "CSF1R" EXACT PRO-short-label [PRO:DNx] synonym: "Csfmr" RELATED Gene-based [] synonym: "FMS" RELATED Gene-based [] synonym: "M-CSF-R" EXACT [] synonym: "proto-oncogene c-Fms" EXACT [] xref: IUPHARobj:1806 xref: PIRSF:PIRSF500947 is_a: PR:000001810 ! CSF-1/PDGF receptor-type tyrosine-protein kinase [Term] id: PR:000002064 name: macrosialin namespace: protein def: "A lysosome-associated membrane protein that is a translation product of the human CD68 gene or a 1:1 ortholog thereof." [PRO:WCB] comment: Category=gene. Requested by=CL. synonym: "CD68" EXACT PRO-short-label [PRO:DNx] synonym: "gp110" RELATED [] is_a: PR:000001883 ! lysosome-associated membrane protein [Term] id: PR:000002065 name: mast/stem cell growth factor receptor namespace: protein def: "A CSF-1/PDGF receptor-type tyrosine-protein kinase that is a translation product of the human KIT gene or a 1:1 ortholog thereof." [PRO:WCB] comment: Category=gene. Requested by=CL. synonym: "CD117" EXACT [] synonym: "KIT" EXACT PRO-short-label [PRO:DNx] synonym: "proto-oncogene c-Kit" EXACT [] synonym: "SCFR" RELATED Gene-based [] synonym: "Sl" RELATED Gene-based [] synonym: "tyrosine-protein kinase Kit" EXACT [] xref: IUPHARobj:1805 xref: PIRSF:PIRSF500951 is_a: PR:000001810 ! CSF-1/PDGF receptor-type tyrosine-protein kinase [Term] id: PR:000002097 name: sodium channel protein type 11 subunit alpha namespace: protein def: "A voltage-gated sodium channel subunit alpha that is a translation product of the human SCN11A gene or a 1:1 ortholog thereof." [PRO:WCB] comment: Category=gene. synonym: "NaN" EXACT [] synonym: "Nat" RELATED Gene-based [] synonym: "peripheral nerve sodium channel 5" EXACT [] synonym: "PN5" EXACT [] synonym: "SCN11A" EXACT PRO-short-label [PRO:DNx] synonym: "SCN12A" RELATED Gene-based [] synonym: "sensory neuron sodium channel 2" EXACT [] synonym: "SNS2" RELATED Gene-based [] synonym: "sodium channel protein type XI subunit alpha" EXACT [] synonym: "sodium channel type 11 subunit alpha" EXACT [] synonym: "voltage-gated sodium channel subunit alpha Nav1.9" EXACT [] xref: IUPHARobj:586 is_a: PR:000001975 ! voltage-gated sodium channel subunit alpha [Term] id: PR:000002104 name: sodium channel protein type 9 subunit alpha namespace: protein def: "A voltage-gated sodium channel subunit alpha that is a translation product of the human SCN9A gene or a 1:1 ortholog thereof." [PRO:WCB] comment: Category=gene. synonym: "Kiaa4197" RELATED Gene-based [] synonym: "NE-Na" EXACT [] synonym: "NENA" RELATED Gene-based [] synonym: "neuroendocrine sodium channel" EXACT [] synonym: "peripheral sodium channel 1" EXACT [] synonym: "PN1" EXACT [] synonym: "SCN9A" EXACT PRO-short-label [PRO:DNx] synonym: "sodium channel protein type IX subunit alpha" EXACT [] synonym: "sodium channel type 9 subunit alpha" EXACT [] synonym: "voltage-gated sodium channel subunit alpha Nav1.7" EXACT [] xref: IUPHARobj:584 is_a: PR:000001975 ! voltage-gated sodium channel subunit alpha [Term] id: PR:000002105 name: thrombomodulin namespace: protein def: "A thrombomodulin-like receptor that is a translation product of the human THBD gene or a 1:1 ortholog thereof." [PRO:WCB] comment: Category=gene. Requested by=CL. synonym: "BDCA-3" EXACT [Wikipedia:Thrombomodulin] synonym: "BDCA3" EXACT [Wikipedia:Thrombomodulin] synonym: "CD141" EXACT [] synonym: "fetomodulin" EXACT [] synonym: "THBD" EXACT PRO-short-label [PRO:DNx] synonym: "THRM" RELATED Gene-based [] synonym: "TM" EXACT [] is_a: PR:000001938 ! thrombomodulin-like receptor [Term] id: PR:000002112 name: vascular endothelial growth factor receptor 2 namespace: protein def: "A vascular endothelial growth factor receptor that is a translation product of the human KDR gene or a 1:1 ortholog thereof." [PRO:WCB] comment: Category=gene. Requested by=CL. synonym: "CD309" EXACT [] synonym: "fetal liver kinase 1" EXACT [] synonym: "FLK-1" EXACT [] synonym: "FLK1" RELATED Gene-based [] synonym: "KDR" EXACT PRO-short-label [PRO:DNx] synonym: "kinase insert domain receptor" EXACT [] synonym: "kinase NYK" EXACT [] synonym: "protein-tyrosine kinase receptor flk-1" EXACT [] synonym: "VEGFR-2" EXACT [] synonym: "VEGFR2" RELATED Gene-based [] xref: IUPHARobj:1813 is_a: PR:000001971 ! vascular endothelial growth factor receptor [Term] id: PR:000002123 name: C-C motif chemokine 3 namespace: protein def: "A C-C motif chemokine 3/4 that is a translation product of the human CCL3 gene or a 1:1 ortholog thereof." [PRO:WCB] comment: Category=gene. synonym: "CCL3" EXACT PRO-short-label [PRO:DNx] synonym: "G0/G1 switch regulatory protein 19-1" EXACT [] synonym: "G0S19-1" RELATED Gene-based [] synonym: "heparin-binding chemotaxis protein" EXACT [] synonym: "L2G25B" EXACT [] synonym: "macrophage inflammatory protein 1-alpha" EXACT [] synonym: "MIP-1-alpha" EXACT [] synonym: "MIP1A" RELATED Gene-based [] synonym: "PAT 464.1" EXACT [] synonym: "SCYA3" RELATED Gene-based [] synonym: "SIS-alpha" EXACT [] synonym: "SIS-beta" EXACT [] synonym: "small-inducible cytokine A3" EXACT [] synonym: "tonsillar lymphocyte LD78 alpha protein" EXACT [] synonym: "TY-5" EXACT [] is_a: PR:000001998 ! C-C motif chemokine 3/4 [Term] id: PR:000002972 name: macrophage mannose receptor 1 namespace: protein def: "A C-type lectin with multiple lectin domains that is a translation product of the human MRC1 gene or a 1:1 ortholog thereof." [PMID:8297379, PRO:CNA] comment: Category=gene. Requested by=CL. synonym: "C-type lectin domain family 13 member D" EXACT [] synonym: "C-type lectin domain family 13 member D-like" RELATED [] synonym: "CD206" EXACT [] synonym: "CLEC13D" RELATED Gene-based [] synonym: "CLEC13DL" RELATED Gene-based [] synonym: "macrophage mannose receptor 1-like protein 1" RELATED [] synonym: "MMR" EXACT [] synonym: "MRC1" EXACT PRO-short-label [PRO:DNx] synonym: "MRC1L1" RELATED Gene-based [] is_a: PR:000001025 ! C-type lectin with multiple lectin domains [Term] id: PR:000002976 name: Ly-6-like protein namespace: protein def: "A protein that is the translation product of any of the LY6 genes (LY6A-LY6I)." [PRO:CNA] comment: Category=family. xref: PIRSF:PIRSF002021 is_a: PR:000000001 ! protein [Term] id: PR:000002977 name: killer cell lectin-like receptor subfamily B member 1C namespace: protein def: "A KLRB1-like protein that is a translation product of the mouse Klrb1c gene or a 1:1 ortholog thereof." [PRO:CNA] comment: Category=gene. Requested by=CL. synonym: "CD161 antigen-like family member C" EXACT [] synonym: "CD161c" EXACT [] synonym: "Klrb1c" EXACT PRO-short-label [PRO:DNx] synonym: "ly-55c" EXACT [] synonym: "Ly55c" RELATED Gene-based [] synonym: "lymphocyte antigen 55c" EXACT [] synonym: "natural killer cell surface protein P1-40" EXACT [] synonym: "NK1.1" EXACT [] synonym: "NKR-P1 40" EXACT [] synonym: "NKR-P1.9" EXACT [] synonym: "NKR-P1C" EXACT [] synonym: "Nkrp1c" RELATED Gene-based [] is_a: PR:000001874 ! KLRB1-like protein [Term] id: PR:000002978 name: lymphocyte antigen 6G namespace: protein def: "An Ly-6-like protein that is a translation product of the mouse Ly6g gene or a 1:1 ortholog thereof." [PRO:CNA] comment: Category=gene. Requested by=CL. synonym: "Ly-6G" EXACT [] synonym: "Ly-6G.1" EXACT [] synonym: "Ly6g" EXACT PRO-short-label [PRO:DNx] is_a: PR:000002976 ! Ly-6-like protein [Term] id: PR:000002979 name: lymphocyte antigen 6A-2/6E-1 namespace: protein def: "An Ly-6-like protein that is a translation product of the mouse Ly6a gene or a 1:1 ortholog thereof." [PRO:CNA] comment: Category=gene. Requested by=CL. synonym: "Ly-6A.2/Ly-6E.1" EXACT [] synonym: "Ly6" RELATED Gene-based [] synonym: "Ly6a" EXACT PRO-short-label [PRO:DNx] synonym: "SCA-1" RELATED [] synonym: "stem cell antigen 1" EXACT [] synonym: "T-cell-activating protein" EXACT [] synonym: "TAP" RELATED [] is_a: PR:000002976 ! Ly-6-like protein [Term] id: PR:000002980 name: lymphocyte antigen 6C2 namespace: protein def: "An Ly-6-like protein that is a translation product of the mouse Ly6c2 gene or a 1:1 ortholog thereof." [PRO:CNA] comment: Category=gene. Requested by=CL. synonym: "Ly-6C2" EXACT [] synonym: "Ly6c" RELATED Gene-based [] synonym: "Ly6c2" EXACT PRO-short-label [PRO:DNx] is_a: PR:000002976 ! Ly-6-like protein [Term] id: PR:000002981 name: lymphocyte antigen 76 (mouse) namespace: protein def: "A protein that is a translation product of the Ly76 gene in mouse." [PMID:10848813, PRO:DAN] comment: Category=organism-gene. Requested by=CL. synonym: "mLy76" EXACT PRO-short-label [PRO:DNx] synonym: "ter-119" EXACT [] synonym: "ter119" EXACT [] is_a: PR:000029032 ! Mus musculus protein [Term] id: PR:000003262 name: collagen alpha chain namespace: protein def: "A protein that is a component of collagen. Collagens are trimeric molecules in which each chain comprises a repeating Gly-X-Y triplet, in which X and Y can be any residue but are usually proline and hydroxyproline, respectively. This results in a left-handed helix that combines with other two to form a triple-helical structure." [Pfam:PF01391, PMID:15788652, PMID:1639194] comment: Category=family. is_a: PR:000000001 ! protein [Term] id: PR:000003263 name: collagen type I alpha chain namespace: protein def: "A collagen alpha chain that is a translation product of the human COL1A1 or COL1A2 genes, 1:1 orthologs thereof, or a semi-ortholog thereof." [PRO:CNA, PRO:DAN] comment: Category=family. is_a: PR:000003262 ! collagen alpha chain [Term] id: PR:000003264 name: collagen alpha-1(I) chain namespace: protein def: "A collagen type I alpha chain that is a translation product of the human COL1A1 gene or a 1:1 ortholog thereof." [PRO:CNA] comment: Category=gene. synonym: "alpha-1 type I collagen" EXACT [] synonym: "COL1A1" EXACT PRO-short-label [PRO:DNx] synonym: "Cola1" RELATED Gene-based [] is_a: PR:000003263 ! collagen type I alpha chain [Term] id: PR:000003328 name: collagen alpha-1(III) chain namespace: protein def: "A collagen alpha chain that is a translation product of the human COL3A1 gene or a 1:1 ortholog thereof." [PRO:CNA] comment: Category=gene. synonym: "COL3A1" EXACT PRO-short-label [PRO:DNx] is_a: PR:000003262 ! collagen alpha chain [Term] id: PR:000003353 name: collagen alpha-1(VI) chain namespace: protein def: "A collagen type VI alpha chain that is a translation product of the human COL6A1 gene or a 1:1 ortholog thereof." [PRO:CNA] comment: Category=gene. synonym: "COL6A1" EXACT PRO-short-label [PRO:DNx] is_a: PR:000003386 ! collagen type VI alpha chain [Term] id: PR:000003386 name: collagen type VI alpha chain namespace: protein def: "A collagen alpha chain that is a translation product of the human COL6A1, COL6A2, or COL6A3 genes, 1:1 orthologs thereof, or a semi-ortholog thereof." [PMID:15788652, PRO:CNA, PRO:DAN] comment: Category=family. is_a: PR:000003262 ! collagen alpha chain [Term] id: PR:000003450 name: B-cell lymphoma 6 protein namespace: protein def: "A protein that is a translation product of the human BCL6 gene or a 1:1 ortholog thereof." [PRO:CNA] comment: Category=gene. Requested by=CL. synonym: "B-cell lymphoma 5 protein" EXACT [] synonym: "BCL-5" EXACT [] synonym: "BCL-6" EXACT [] synonym: "BCL5" RELATED Gene-based [] synonym: "BCL6" EXACT PRO-short-label [PRO:DNx] synonym: "LAZ3" RELATED Gene-based [] synonym: "protein LAZ-3" EXACT [] synonym: "ZBTB27" RELATED Gene-based [] synonym: "zinc finger and BTB domain-containing protein 27" EXACT [] synonym: "zinc finger protein 51" EXACT [] synonym: "ZNF51" RELATED Gene-based [] xref: IUPHARobj:2957 is_a: PR:000000001 ! protein [Term] id: PR:000003455 name: nuclear receptor ROR-gamma isoform 2 namespace: protein def: "A nuclear receptor ROR-gamma that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P51450-2 or a 1:1 ortholog thereof." [PRO:CNA] comment: Category=sequence. Requested by=CL. synonym: "RORC/iso:2" EXACT PRO-short-label [PRO:DNx] is_a: PR:000001902 ! nuclear receptor ROR-gamma [Term] id: PR:000003457 name: V(D)J recombination-activating protein 1 namespace: protein def: "A protein that is a translation product of the human RAG1 gene or a 1:1 ortholog thereof." [PRO:CNA] comment: Category=gene. Requested by=CL. synonym: "RAG-1" EXACT [] synonym: "RAG1" EXACT PRO-short-label [PRO:DNx] synonym: "RING finger protein 74" EXACT [] synonym: "RNF74" RELATED Gene-based [] is_a: PR:000000001 ! protein [Term] id: PR:000003460 name: V(D)J recombination-activating protein 2 namespace: protein def: "A protein that is a translation product of the human RAG2 gene or a 1:1 ortholog thereof." [PRO:CNA] comment: Category=gene. Requested by=CL. synonym: "RAG-2" EXACT [] synonym: "RAG2" EXACT PRO-short-label [PRO:DNx] is_a: PR:000000001 ! protein [Term] id: PR:000003463 name: eomesodermin namespace: protein def: "A T-brain transcription factor that is a translation product of the human EOMES gene or a 1:1 ortholog thereof." [PMID:10407135, PRO:CNA] comment: Category=gene. Requested by=CL. synonym: "EOMES" EXACT PRO-short-label [PRO:DNx] synonym: "T-box brain protein 2" EXACT [] synonym: "T-brain-2" EXACT [] synonym: "TBR-2" EXACT [] synonym: "TBR2" RELATED Gene-based [] is_a: PR:000003506 ! T-brain transcription factor [Term] id: PR:000003466 name: perforin-1 namespace: protein def: "A protein that is a translation product of the human PRF1 gene or a 1:1 ortholog thereof." [PRO:CNA] comment: Category=gene. Requested by=CL. synonym: "cytolysin" EXACT [] synonym: "lymphocyte pore-forming protein" EXACT [] synonym: "P1" RELATED [] synonym: "PFP" RELATED Gene-based [] synonym: "PRF1" EXACT PRO-short-label [PRO:DNx] is_a: CHEBI:36080 [Term] id: PR:000003469 name: early growth response protein 2 namespace: protein def: "A protein that is a translation product of the human EGR2 gene or a 1:1 ortholog thereof." [PRO:CNA] comment: Category=gene. Requested by=CL. synonym: "AT591" EXACT [] synonym: "E3 SUMO-protein transferase ERG2" EXACT [] synonym: "EGR-2" EXACT [] synonym: "EGR2" EXACT PRO-short-label [PRO:DNx] synonym: "Krox-20" RELATED Gene-based [] synonym: "KROX20" RELATED Gene-based [] synonym: "Zfp-25" RELATED Gene-based [] synonym: "zinc finger protein Krox-20" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000003472 name: granzyme K namespace: protein def: "A leukocyte granule-associated proteinase that is a translation product of the human GZMK gene or a 1:1 ortholog thereof." [PRO:CNA] comment: Category=gene. synonym: "GZMK" EXACT PRO-short-label [PRO:DNx] synonym: "Gzmk" RELATED [] synonym: "TRYP2" RELATED Gene-based [] xref: IUPHARobj:2370 is_a: PR:000003505 ! leukocyte granule-associated proteinase [Term] id: PR:000003490 name: granzyme H namespace: protein def: "A leukocyte granule-associated proteinase that is a translation product of the human GZMH gene or a 1:1 ortholog thereof." [PRO:CNA] comment: Category=gene. synonym: "cathepsin G-like 2" EXACT [] synonym: "CCP-X" EXACT [] synonym: "CGL2" RELATED Gene-based [] synonym: "CSP-C" RELATED [] synonym: "CTSGL2" RELATED Gene-based [] synonym: "cytotoxic serine protease C" EXACT [] synonym: "cytotoxic T-lymphocyte proteinase" EXACT [] synonym: "GZMH" EXACT PRO-short-label [PRO:DNx] is_a: PR:000003505 ! leukocyte granule-associated proteinase [Term] id: PR:000003499 name: granzyme B namespace: protein def: "A leukocyte granule-associated proteinase that is a translation product of the human GZMB gene or a 1:1 ortholog thereof." [PRO:CNA] comment: Category=gene. Requested by=CL. synonym: "C11" EXACT [] synonym: "cathepsin G-like 1" EXACT [] synonym: "CGL1" RELATED Gene-based [] synonym: "CSPB" RELATED Gene-based [] synonym: "CTLA-1" BROAD [PRO:DNx] synonym: "CTLA1" RELATED Gene-based [] synonym: "CTSGL1" EXACT [] synonym: "cytotoxic T-lymphocyte proteinase 2" EXACT [] synonym: "fragmentin-2" BROAD [PRO:DNx] synonym: "granzyme-2" EXACT [] synonym: "GRB" RELATED Gene-based [] synonym: "GZMB" EXACT PRO-short-label [PRO:DNx] synonym: "HLP" RELATED [] synonym: "lymphocyte protease" EXACT [] synonym: "SECT" EXACT [] synonym: "T-cell serine protease 1-3E" EXACT [] xref: IUPHARobj:2369 is_a: PR:000003505 ! leukocyte granule-associated proteinase [Term] id: PR:000003505 name: leukocyte granule-associated proteinase namespace: protein def: "A trypsin that is a serine protease of the granules from mast cells, cytotoxic T lymphocytes and/or natural killer cells. Leukocyte granule-associated proteinase is a component of the immune system that protect higher organisms against viral infection and cellular transformation. Members of this class have features that are strongly conserved including: consensus sequences at their N-termini and around the three catalytic residues, activation from zymogenic forms, and conserved disulphide bridges." [PMID:11790262, PMID:7952649, PMID:8929545] comment: Category=family. is_a: PR:000027795 ! trypsin [Term] id: PR:000003506 name: T-brain transcription factor namespace: protein def: "A protein that contains one copy of the T-box domain (Pfam:PF00907) and it is involved in the anterior neural specification." [PMID:10750050, PMID:12210112] comment: Category=family. synonym: "Eomes/Tbr1/Tbx21 family protein" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000003516 name: lactosylceramide 4-alpha-galactosyltransferase namespace: protein def: "A protein that is a translation product of the human A4GALT gene or a 1:1 ortholog thereof." [PRO:DNx] comment: Category=gene. Requested by=CL. synonym: "A14GALT" RELATED Gene-based [] synonym: "A4GALT" EXACT PRO-short-label [PRO:DNx] synonym: "A4GALT1" RELATED Gene-based [] synonym: "alpha-1,4-galactosyltransferase" EXACT [] synonym: "alpha-1,4-N-acetylglucosaminyltransferase" BROAD [PRO:DNx] synonym: "alpha4Gal-T1" EXACT [] synonym: "CD77 synthase" EXACT [] synonym: "Gb3 synthase" EXACT [] synonym: "globotriaosylceramide synthase" EXACT [] synonym: "P1/Pk synthase" EXACT [] synonym: "UDP-galactose:beta-D-galactosyl-beta1-R 4-alpha-D-galactosyltransferase" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000003675 name: actin, aortic smooth muscle namespace: protein def: "A protein that is a translation product of the human ACTA2 gene or a 1:1 ortholog thereof." [PRO:DNx] comment: Category=gene. synonym: "ACTA2" EXACT PRO-short-label [PRO:DNx] synonym: "ACTSA" RELATED Gene-based [] synonym: "ACTVS" RELATED Gene-based [] synonym: "alpha-actin-2" EXACT [] synonym: "cell growth-inhibiting gene 46 protein" EXACT [] synonym: "GIG46" RELATED Gene-based [] is_a: PR:000000001 ! protein [Term] id: PR:000003846 name: agouti-related protein namespace: protein def: "A protein that is a translation product of the human AGRP gene or a 1:1 ortholog thereof." [PRO:DNx] comment: Category=gene. synonym: "AGRP" EXACT PRO-short-label [PRO:DNx] synonym: "AGRT" RELATED Gene-based [] synonym: "ART" RELATED Gene-based [] is_a: PR:000000001 ! protein [Term] id: PR:000004528 name: tyrosine-protein kinase receptor UFO namespace: protein def: "A protein that is a translation product of the human AXL gene or a 1:1 ortholog thereof." [PRO:DNx] comment: Category=gene. synonym: "adhesion-related kinase" EXACT [] synonym: "Ark" RELATED Gene-based [] synonym: "AXL" EXACT PRO-short-label [PRO:DNx] synonym: "AXL oncogene" EXACT [] synonym: "UFO" RELATED Gene-based [] xref: IUPHARobj:1835 is_a: PR:000000001 ! protein [Term] id: PR:000004621 name: BAG family molecular chaperone regulator 3 namespace: protein def: "A protein that is a translation product of the human BAG3 gene or a 1:1 ortholog thereof." [PRO:DNx] comment: Category=gene. synonym: "BAG-3" EXACT [] synonym: "BAG3" EXACT PRO-short-label [PRO:DNx] synonym: "Bcl-2-associated athanogene 3" EXACT [] synonym: "Bcl-2-binding protein Bis" EXACT [] synonym: "BIS" RELATED Gene-based [] synonym: "docking protein CAIR-1" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000004691 name: B-cell lymphoma/leukemia 11B namespace: protein def: "A protein that is a translation product of the human BCL11B gene or a 1:1 ortholog thereof." [PRO:DNx] comment: Category=gene. synonym: "B-cell CLL/lymphoma 11B" EXACT [] synonym: "BCL-11B" EXACT [] synonym: "BCL11B" EXACT PRO-short-label [PRO:DNx] synonym: "COUP-TF-interacting protein 2" EXACT [] synonym: "CTIP2" RELATED Gene-based [] synonym: "radiation-induced tumor suppressor gene 1 protein" EXACT [] synonym: "RIT1" RELATED Gene-based [] synonym: "Rit1" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000004724 name: bestrophin-4 namespace: protein def: "A protein that is a translation product of the human BEST4 gene or a 1:1 ortholog thereof." [PRO:DNx] comment: Category=gene. synonym: "BEST4" EXACT PRO-short-label [PRO:DNx] synonym: "vitelliform macular dystrophy 2-like protein 2" EXACT [] synonym: "VMD2L2" RELATED Gene-based [] is_a: PR:000000001 ! protein [Term] id: PR:000004919 name: carbonic anhydrase 3 namespace: protein def: "A single domain alpha-type carbonic anhydrase that is a translation product of the human CA3 gene or a 1:1 ortholog thereof." [PRO:DNx] comment: Category=gene. synonym: "CA-III" EXACT [] synonym: "CA3" EXACT PRO-short-label [PRO:DNx] synonym: "Car3" RELATED Gene-based [] synonym: "carbonate dehydratase III" EXACT [] synonym: "carbonic anhydrase III" EXACT [] is_a: PR:000025841 ! single domain alpha-type carbonic anhydrase [Term] id: PR:000004973 name: calcitonin gene-related peptide type 1 receptor namespace: protein def: "A calcitonin receptor protein that is a translation product of the human CALCRL gene or a 1:1 ortholog thereof." [PRO:DAN] comment: Category=gene. synonym: "calcitonin receptor-like receptor" EXACT [] synonym: "CALCRL" EXACT PRO-short-label [PRO:DNx] synonym: "CGRP type 1 receptor" EXACT [] synonym: "CGRPR" RELATED Gene-based [] synonym: "Crlr" RELATED Gene-based [] xref: IUPHARobj:47 is_a: PR:000044637 ! calcitonin receptor protein [Term] id: PR:000004984 name: calreticulin namespace: protein def: "A protein that is a translation product of the human CALR gene or a 1:1 ortholog thereof." [PRO:DNx] comment: Category=gene. synonym: "CALR" EXACT PRO-short-label [PRO:DNx] synonym: "calregulin" EXACT [] synonym: "CRP55" EXACT [] synonym: "CRTC" RELATED Gene-based [] synonym: "endoplasmic reticulum resident protein 60" RELATED [] synonym: "ERp60" RELATED [] synonym: "grp60" EXACT [] synonym: "HACBP" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000005110 name: cholecystokinin namespace: protein def: "A protein that is a translation product of the human CCK gene or a 1:1 ortholog thereof." [PRO:DNx] comment: Category=gene. synonym: "CCK" EXACT PRO-short-label [PRO:DNx] is_a: PR:000000001 ! protein [Term] id: PR:000005178 name: CD9 molecule namespace: protein def: "A tetraspanin that is a translation product of the human CD9 gene or a 1:1 ortholog thereof." [PRO:DNx] comment: Category=gene. Requested by=CL. synonym: "5H9 antigen" EXACT [] synonym: "CD9" EXACT PRO-short-label [PRO:DNx] synonym: "CD9 antigen" EXACT [] synonym: "cell growth-inhibiting gene 2 protein" EXACT [] synonym: "GIG2" RELATED Gene-based [] synonym: "leukocyte antigen MIC3" EXACT [] synonym: "MIC3" RELATED Gene-based [] synonym: "motility-related protein" EXACT [] synonym: "MRP-1" EXACT [] synonym: "p24" BROAD [PRO:DNx] synonym: "tetraspanin-29" EXACT [] synonym: "tspan-29" EXACT [] synonym: "TSPAN29" RELATED Gene-based [] is_a: PR:000001403 ! tetraspanin [Term] id: PR:000005307 name: CCAAT/enhancer-binding protein alpha namespace: protein def: "A protein that is a translation product of the human CEBPA gene or a 1:1 ortholog thereof." [PRO:DNx] comment: Category=gene. Requested by=CL. synonym: "C/EBP alpha" EXACT [] synonym: "CEBP" RELATED Gene-based [] synonym: "CEBPA" EXACT PRO-short-label [PRO:DNx] is_a: PR:000000001 ! protein [Term] id: PR:000005310 name: CCAAT/enhancer-binding protein epsilon namespace: protein def: "A protein that is a translation product of the human CEBPE gene or a 1:1 ortholog thereof." [PRO:DNx] comment: Category=gene. Requested by=CL. synonym: "C/EBP epsilon" EXACT [] synonym: "CEBPE" EXACT PRO-short-label [PRO:DNx] synonym: "Gm294" RELATED Gene-based [] is_a: PR:000000001 ! protein [Term] id: PR:000005404 name: choline O-acetyltransferase namespace: protein def: "A protein that is a translation product of the human CHAT gene or a 1:1 ortholog thereof." [PRO:DNx] comment: Category=gene. synonym: "CHAT" EXACT PRO-short-label [PRO:DNx] synonym: "ChAT" EXACT [] synonym: "CHOACTase" EXACT [] synonym: "choline acetylase" EXACT [] xref: IUPHARobj:2480 is_a: PR:000000001 ! protein [Term] id: PR:000005444 name: chondrolectin namespace: protein def: "A protein that is a translation product of the human CHODL gene or a 1:1 ortholog thereof." [PRO:DNx] comment: Category=gene. synonym: "C21orf68" RELATED Gene-based [] synonym: "CHODL" EXACT PRO-short-label [PRO:DNx] synonym: "PRED12" RELATED Gene-based [] synonym: "transmembrane protein MT75" EXACT [] synonym: "UNQ872/PRO1890" RELATED Gene-based [] is_a: PR:000000001 ! protein [Term] id: PR:000005460 name: neuronal acetylcholine receptor subunit alpha-7 namespace: protein def: "A nicotinic acetylcholine receptor protein that is a translation product of the human CHRNA7 gene or a 1:1 ortholog thereof." [PRO:DNx] comment: Category=gene. synonym: "Acra7" RELATED Gene-based [] synonym: "CHRNA7" EXACT PRO-short-label [PRO:DNx] synonym: "NACHRA7" RELATED Gene-based [] xref: IUPHARobj:468 is_a: PR:000044668 ! nicotinic acetylcholine receptor protein [Term] id: PR:000005693 name: collagen alpha-1(X) chain namespace: protein def: "A protein that is a translation product of the human COL10A1 gene or a 1:1 ortholog thereof." [PRO:DNx] comment: Category=gene. synonym: "COL10A1" EXACT PRO-short-label [PRO:DNx] is_a: PR:000000001 ! protein [Term] id: PR:000005694 name: collagen alpha-1(XI) chain namespace: protein def: "A protein that is a translation product of the human COL11A1 gene or a 1:1 ortholog thereof." [PRO:DNx] comment: Category=gene. synonym: "COL11A1" EXACT PRO-short-label [PRO:DNx] synonym: "COLL6" RELATED Gene-based [] is_a: PR:000000001 ! protein [Term] id: PR:000006169 name: cell surface glycoprotein CD200 receptor 3 namespace: protein def: "A protein that is a translation product of the mouse Cd200r3 gene or a 1:1 ortholog thereof." [PRO:DNx] comment: Category=gene. Requested by=CL. synonym: "CD200 cell surface glycoprotein receptor-like 3" EXACT [] synonym: "CD200 cell surface glycoprotein receptor-like b" EXACT [] synonym: "CD200 receptor-like 3" EXACT [] synonym: "Cd200r3" EXACT PRO-short-label [PRO:DNx] synonym: "CD200RLb" EXACT [] synonym: "cell surface glycoprotein OX2 receptor 3" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000006172 name: CD209 molecule-like protein B namespace: protein def: "A protein that is a translation product of the mouse Cd209b gene or a 1:1 ortholog thereof." [PRO:DNx] comment: Category=gene. Requested by=CL. synonym: "Cd209b" EXACT PRO-short-label [PRO:DNx] synonym: "DC-SIGN-related protein 1" EXACT [] synonym: "DC-SIGNR1" EXACT [] synonym: "OtB7" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000006294 name: dopamine beta-hydroxylase namespace: protein def: "A protein that is a translation product of the human DBH gene or a 1:1 ortholog thereof." [PRO:DNx] comment: Category=gene. synonym: "DBH" EXACT PRO-short-label [PRO:DNx] synonym: "dopamine beta-monooxygenase" EXACT [] xref: IUPHARobj:2486 is_a: PR:000000001 ! protein [Term] id: PR:000006611 name: DNA nucleotidylexotransferase namespace: protein def: "A protein that is a translation product of the human DNTT gene or a 1:1 ortholog thereof." [PRO:DNx] comment: Category=gene. Requested by=CL. synonym: "DNTT" EXACT PRO-short-label [PRO:DNx] synonym: "TDT" RELATED Gene-based [] synonym: "terminal addition enzyme" EXACT [] synonym: "terminal deoxynucleotidyltransferase" EXACT [] synonym: "terminal transferase" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000006646 name: dipeptidase 1 namespace: protein def: "A protein that is a translation product of the human DPEP1 gene or a 1:1 ortholog thereof." [PRO:DNx] comment: Category=gene. synonym: "beta-lactamase" BROAD [] synonym: "dehydropeptidase-I" EXACT [] synonym: "DPEP1" EXACT PRO-short-label [PRO:DNx] synonym: "MBD-1" EXACT [] synonym: "Mbd1" RELATED Gene-based [] synonym: "MDP" RELATED Gene-based [] synonym: "membrane-bound dipeptidase 1" EXACT [] synonym: "microsomal dipeptidase" EXACT [] synonym: "RDP" RELATED Gene-based [] synonym: "renal dipeptidase" EXACT [] xref: IUPHARobj:1393 is_a: PR:000000001 ! protein [Term] id: PR:000006897 name: endothelin-1 namespace: protein def: "A protein that is a translation product of the human EDN1 gene or a 1:1 ortholog thereof." [PRO:DNx] comment: Category=gene. synonym: "EDN1" EXACT PRO-short-label [PRO:DNx] synonym: "ET-1" EXACT [] synonym: "PPET1" EXACT [] synonym: "preproendothelin-1" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000007152 name: eosinophil peroxidase namespace: protein def: "A protein that is a translation product of the human EPX gene or a 1:1 ortholog thereof." [PRO:DNx] comment: Category=gene. Requested by=CL. synonym: "EPER" RELATED Gene-based [] synonym: "EPO" BROAD Gene-based [PRO:DNx] synonym: "EPP" RELATED Gene-based [] synonym: "EPX" EXACT PRO-short-label [PRO:DNx] is_a: PR:000000001 ! protein [Term] id: PR:000007204 name: estrogen receptor namespace: protein def: "A protein that is a translation product of the human ESR1 gene or a 1:1 ortholog thereof." [PRO:DNx] comment: Category=gene. synonym: "ER" EXACT [] synonym: "ER-alpha" EXACT [] synonym: "ESR" RELATED Gene-based [] synonym: "ESR1" EXACT PRO-short-label [PRO:DNx] synonym: "Estr" RELATED Gene-based [] synonym: "Estra" RELATED Gene-based [] synonym: "estradiol receptor" EXACT [] synonym: "NR3A1" RELATED Gene-based [] synonym: "nuclear receptor subfamily 3 group A member 1" EXACT [] xref: IUPHARobj:620 is_a: PR:000000001 ! protein [Term] id: PR:000007431 name: high affinity immunoglobulin epsilon receptor subunit alpha namespace: protein def: "An immunoglobulin gamma Fc receptor II/III/IV that is a translation product of the human FCER1A gene or a 1:1 ortholog thereof." [PRO:DNx] comment: Category=gene. Requested by=CL. synonym: "Fc-epsilon RI-alpha" EXACT [] synonym: "FCE1A" RELATED Gene-based [] synonym: "FCER1A" EXACT PRO-short-label [PRO:DNx] synonym: "FcERI" RELATED [] synonym: "IgE Fc receptor subunit alpha" EXACT [] xref: IUPHARobj:2933 is_a: PR:000001355 ! immunoglobulin gamma Fc receptor II/III/IV [Term] id: PR:000007479 name: fibroblast growth factor 1 namespace: protein def: "A protein that is a translation product of the human FGF1 gene or a 1:1 ortholog thereof." [PRO:DNx] comment: Category=gene. synonym: "acidic fibroblast growth factor" EXACT [] synonym: "aFGF" EXACT [] synonym: "beta-endothelial cell growth factor" EXACT [] synonym: "ECGF-beta" EXACT [] synonym: "Fgf-1" RELATED Gene-based [] synonym: "FGF1" EXACT PRO-short-label [PRO:DNx] synonym: "FGFA" RELATED Gene-based [] synonym: "HBGF-1" EXACT [] synonym: "heparin-binding growth factor 1" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000007489 name: fibroblast growth factor 2 namespace: protein def: "A protein that is a translation product of the human FGF2 gene or a 1:1 ortholog thereof." [PRO:DNx] comment: Category=gene. synonym: "basic fibroblast growth factor" EXACT [] synonym: "BFGF" EXACT [] synonym: "Fgf-2" RELATED Gene-based [] synonym: "FGF2" EXACT PRO-short-label [PRO:DNx] synonym: "FGFB" RELATED Gene-based [] synonym: "HBGF-2" EXACT [] synonym: "heparin-binding growth factor 2" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000007498 name: fibroblast growth factor 7 namespace: protein def: "A protein that is a translation product of the human FGF7 gene or a 1:1 ortholog thereof." [PRO:DNx] comment: Category=gene. synonym: "FGF-7" EXACT [] synonym: "FGF7" EXACT PRO-short-label [PRO:DNx] synonym: "HBGF-7" EXACT [] synonym: "heparin-binding growth factor 7" EXACT [] synonym: "keratinocyte growth factor" EXACT [] synonym: "KGF" RELATED Gene-based [] is_a: PR:000000001 ! protein [Term] id: PR:000007499 name: fibroblast growth factor 8 namespace: protein def: "A protein that is a translation product of the human FGF8 gene or a 1:1 ortholog thereof." [PRO:DNx] comment: Category=gene. synonym: "AIGF" RELATED Gene-based [] synonym: "androgen-induced growth factor" EXACT [] synonym: "FGF-8" EXACT [] synonym: "FGF8" EXACT PRO-short-label [PRO:DNx] synonym: "HBGF-8" RELATED [] synonym: "heparin-binding growth factor 8" RELATED [] is_a: PR:000000001 ! protein [Term] id: PR:000007597 name: protein c-Fos namespace: protein def: "A protein that is a translation product of the human FOS gene or a 1:1 ortholog thereof." [PRO:DNx] comment: Category=gene. Requested by=CL. synonym: "cellular oncogene fos" EXACT [] synonym: "FOS" EXACT PRO-short-label [PRO:DNx] synonym: "G0/G1 switch regulatory protein 7" EXACT [] synonym: "G0S7" RELATED Gene-based [] synonym: "proto-oncogene protein c-fos" EXACT [] synonym: "transcription factor AP-1 subunit c-Fos" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000007636 name: forkhead box protein N1 namespace: protein def: "A protein that is a translation product of the human FOXN1 gene or a 1:1 ortholog thereof." [PRO:DNx] comment: Category=gene. synonym: "Fkh19" RELATED Gene-based [] synonym: "FOXN1" EXACT PRO-short-label [PRO:DNx] synonym: "hepatocyte nuclear factor 3 forkhead homolog 11" RELATED [] synonym: "HFH-11" RELATED [] synonym: "Hfh11" RELATED Gene-based [] synonym: "HNF-3/forkhead homolog 11" EXACT [] synonym: "RONU" RELATED Gene-based [] synonym: "WHN" RELATED Gene-based [] synonym: "winged-helix transcription factor nude" EXACT [] xref: IUPHARobj:2958 is_a: PR:000000001 ! protein [Term] id: PR:000007643 name: forkhead box protein P1 namespace: protein def: "A protein that is a translation product of the human FOXP1 gene or a 1:1 ortholog thereof." [PRO:DNx] comment: Category=gene. synonym: "forkhead-related transcription factor 1" RELATED [] synonym: "FOXP1" EXACT PRO-short-label [PRO:DNx] synonym: "HSPC215" RELATED Gene-based [] is_a: PR:000000001 ! protein [Term] id: PR:000007785 name: glutamate decarboxylase 1 namespace: protein def: "A protein that is a translation product of the human GAD1 gene or a 1:1 ortholog thereof." [PRO:DNx] comment: Category=gene. synonym: "67 kDa glutamic acid decarboxylase" EXACT [] synonym: "GAD" RELATED Gene-based [] synonym: "GAD-67" EXACT [] synonym: "GAD1" EXACT PRO-short-label [PRO:DNx] synonym: "GAD67" RELATED Gene-based [] synonym: "glutamate decarboxylase 67 kDa isoform" EXACT [] xref: IUPHARobj:1272 is_a: CHEBI:36080 [Term] id: PR:000007806 name: galanin namespace: protein def: "A protein that is a translation product of the human GAL gene or a 1:1 ortholog thereof." [PRO:DNx] comment: Category=gene. synonym: "GAL" EXACT PRO-short-label [PRO:DNx] synonym: "GAL1" RELATED Gene-based [] synonym: "GALN" RELATED Gene-based [] synonym: "GLNN" RELATED Gene-based [] is_a: PR:000000001 ! protein [Term] id: PR:000007857 name: erythroid transcription factor namespace: protein def: "A protein that is a translation product of the human GATA1 gene or a 1:1 ortholog thereof." [PRO:DNx] comment: Category=gene. Requested by=CL. synonym: "ERYF1" RELATED Gene-based [] synonym: "Eryf1" EXACT [] synonym: "GATA-1" EXACT [] synonym: "GATA-binding factor 1" EXACT [] synonym: "GATA1" EXACT PRO-short-label [PRO:DNx] synonym: "GF-1" RELATED [] synonym: "GF1" RELATED Gene-based [] synonym: "NF-E1 DNA-binding protein" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000007858 name: endothelial transcription factor GATA-2 namespace: protein def: "A protein that is a translation product of the human GATA2 gene or a 1:1 ortholog thereof." [PRO:DNx] comment: Category=gene. Requested by=CL. synonym: "GATA-binding protein 2" EXACT [] synonym: "GATA2" EXACT PRO-short-label [PRO:DNx] is_a: PR:000000001 ! protein [Term] id: PR:000007939 name: glial fibrillary acidic protein namespace: protein def: "A protein that is a translation product of the human GFAP gene or a 1:1 ortholog thereof." [PRO:DNx] comment: Category=gene. Requested by=CL. synonym: "GFAP" EXACT PRO-short-label [PRO:DNx] is_a: PR:000000001 ! protein [Term] id: PR:000008457 name: beta-globin namespace: protein def: "A hemoglobin subunit that is a translation product of the human HBB gene, a 1:1 ortholog thereof, or pro-orthologs thereof." [PRO:DAN] comment: Category=gene. synonym: "b-globin" EXACT PRO-short-label [PRO:DNx] is_a: PR:000050467 ! hemoglobin subunit [Term] id: PR:000008467 name: hemoglobin subunit zeta namespace: protein def: "A hemoglobin subunit that is a translation product of the human HBZ gene or a 1:1 ortholog thereof." [PRO:DNx] comment: Category=gene. Requested by=CL. synonym: "alpha-like embryonic globin chain x" EXACT [] synonym: "Hba-x" RELATED Gene-based [] synonym: "HBAZ" EXACT [] synonym: "HBZ" EXACT PRO-short-label [PRO:DNx] synonym: "Hbz1" RELATED Gene-based [] synonym: "HBZ2" RELATED Gene-based [] synonym: "hemoglobin zeta chain" EXACT [] synonym: "zeta-globin" EXACT [] is_a: PR:000050467 ! hemoglobin subunit [Term] id: PR:000008857 name: hemoglobin subunit beta-1 namespace: protein def: "A beta-globin that is a translation product of the mouse Hbb-b1 gene or a 1:1 ortholog thereof." [PRO:DNx] comment: Category=gene. Requested by=CL. synonym: "beta-1-globin" EXACT [] synonym: "Hbb-b1" EXACT PRO-short-label [PRO:DNx] synonym: "hemoglobin beta-1 chain" EXACT [] synonym: "hemoglobin beta-major chain" EXACT [] is_a: PR:000008457 ! beta-globin [Term] id: PR:000008982 name: interleukin-17 receptor B namespace: protein def: "A protein that is a translation product of the human IL17RB gene or a 1:1 ortholog thereof." [PRO:DNx] comment: Category=gene. Requested by=CL. synonym: "CRL4" RELATED Gene-based [] synonym: "cytokine receptor-like 4" EXACT [] synonym: "EVI27" RELATED Gene-based [] synonym: "IL-17 receptor B" EXACT [] synonym: "IL-17 receptor homolog 1" EXACT [] synonym: "IL-17B receptor" EXACT [] synonym: "IL-17ER" EXACT [] synonym: "IL-17RB" EXACT [] synonym: "IL-17Rh1" EXACT [] synonym: "IL17BR" RELATED Gene-based [] synonym: "IL17RB" EXACT PRO-short-label [PRO:DNx] synonym: "IL17Rh1" EXACT [] synonym: "interleukin-17B receptor" EXACT [] synonym: "UNQ2501/PRO19612" RELATED Gene-based [] xref: IUPHARobj:1739 is_a: PR:000000001 ! protein [Term] id: PR:000008994 name: interleukin-1 receptor-like 1 namespace: protein def: "A protein that is a translation product of the human IL1RL1 gene or a 1:1 ortholog thereof." [PRO:DNx] comment: Category=gene. Requested by=CL. synonym: "DER4" RELATED Gene-based [] synonym: "IL1RL1" EXACT PRO-short-label [PRO:DNx] synonym: "Ly84" RELATED Gene-based [] synonym: "lymphocyte antigen 84" EXACT [] synonym: "protein ST2" EXACT [] synonym: "protein T1" EXACT [] synonym: "ST2" RELATED Gene-based [] synonym: "Ste2" RELATED Gene-based [] synonym: "T1" RELATED Gene-based [] xref: IUPHARobj:1735 is_a: PR:000000001 ! protein [Term] id: PR:000009054 name: preproinsulin namespace: protein def: "An insulin family protein that is a translation product of the human INS gene or a 1:1 ortholog thereof." [PRO:DNx] comment: Category=gene. synonym: "INS" EXACT PRO-short-label [PRO:DNx] is_a: PR:000045358 ! insulin family protein [Term] id: PR:000009127 name: integrin alpha-IIb namespace: protein def: "An integrin alpha lacking A domain that is a translation product of the human ITGA2B gene or a 1:1 ortholog thereof." [PRO:DNx] comment: Category=gene. Requested by=CL. synonym: "CD41" EXACT [] synonym: "GP2B" RELATED Gene-based [] synonym: "GPalpha IIb" EXACT [] synonym: "GPIIb" EXACT [] synonym: "ITGA2B" EXACT PRO-short-label [PRO:DNx] synonym: "ITGAB" RELATED Gene-based [] synonym: "platelet membrane glycoprotein IIb" EXACT [] xref: IUPHARobj:2441 is_a: PR:000025797 ! integrin alpha lacking A domain [Term] id: PR:000009129 name: integrin alpha-4 namespace: protein def: "An integrin alpha lacking A domain that is a translation product of the human ITGA4 gene or a 1:1 ortholog thereof." [PRO:DNx] comment: Category=gene. Requested by=CL. synonym: "CD49 antigen-like family member D" EXACT [] synonym: "CD49D" RELATED Gene-based [] synonym: "CD49d" EXACT [] synonym: "integrin alpha-IV" EXACT [] synonym: "ITGA4" EXACT PRO-short-label [PRO:DNx] synonym: "LPAM subunit alpha" EXACT [] synonym: "lymphocyte Peyer patch adhesion molecules subunit alpha" EXACT [] synonym: "VLA-4 subunit alpha" EXACT [] xref: IUPHARobj:2443 is_a: PR:000025797 ! integrin alpha lacking A domain [Term] id: PR:000009143 name: integrin beta-7 namespace: protein def: "An integrin beta that is a translation product of the human ITGB7 gene or a 1:1 ortholog thereof." [PRO:DNx] comment: Category=gene. Requested by=CL. synonym: "Gut homing receptor beta subunit" EXACT [] synonym: "integrin beta-P" EXACT [] synonym: "ITGB7" EXACT PRO-short-label [PRO:DNx] synonym: "M290 IEL antigen" EXACT [] xref: IUPHARobj:2461 is_a: PR:000001861 ! integrin beta [Term] id: PR:000009344 name: metastasis-suppressor KiSS-1 namespace: protein def: "A protein that is a translation product of the human KISS1 gene or a 1:1 ortholog thereof." [PRO:DNx] comment: Category=gene. synonym: "KISS1" EXACT PRO-short-label [PRO:DNx] synonym: "kisspeptin-1" EXACT [] synonym: "PP5098" RELATED Gene-based [] is_a: PR:000000001 ! protein [Term] id: PR:000009426 name: killer cell lectin-like receptor subfamily G member 1 namespace: protein def: "A protein that is a translation product of the human KLRG1 gene or a 1:1 ortholog thereof." [PRO:DNx] comment: Category=gene. synonym: "C-type lectin domain family 15 member A" EXACT [] synonym: "CLEC15A" RELATED Gene-based [] synonym: "ITIM-containing receptor MAFA-L" EXACT [] synonym: "KLRG1" EXACT PRO-short-label [PRO:DNx] synonym: "MAFA" RELATED Gene-based [] synonym: "MAFA-like receptor" EXACT [] synonym: "MAFAL" RELATED Gene-based [] synonym: "mast cell function-associated antigen" EXACT [] synonym: "mast cell function-associated antigen 2F1" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000009616 name: T-cell surface glycoprotein YE1/48 namespace: protein def: "A protein that is a translation product of the mouse Klra1 gene or a 1:1 ortholog thereof." [PRO:DNx] comment: Category=gene. Requested by=CL. synonym: "Klra1" EXACT PRO-short-label [PRO:DNx] synonym: "Ly-49" RELATED Gene-based [] synonym: "ly-49a" EXACT [] synonym: "Ly49" RELATED Gene-based [] synonym: "Ly49A" RELATED Gene-based [] synonym: "lymphocyte antigen 49a" EXACT [] synonym: "T lymphocyte antigen A1" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000009618 name: killer cell lectin-like receptor 3 namespace: protein def: "A protein that is a translation product of the mouse Klra3 gene or a 1:1 ortholog thereof." [PRO:DNx] comment: Category=gene. Requested by=CL. synonym: "5E6" EXACT [] synonym: "Klra3" EXACT PRO-short-label [PRO:DNx] synonym: "ly-49c" EXACT [] synonym: "Ly49C" RELATED Gene-based [] synonym: "lymphocyte antigen 49c" EXACT [] synonym: "T-cell surface glycoprotein Ly-49C" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000009619 name: killer cell lectin-like receptor 4 namespace: protein def: "A protein that is a translation product of the mouse Klra4 gene or a 1:1 ortholog thereof." [PRO:DNx] comment: Category=gene. Requested by=CL. synonym: "Klra4" EXACT PRO-short-label [PRO:DNx] synonym: "ly-49d" EXACT [] synonym: "Ly49-d" RELATED Gene-based [] synonym: "Ly49d" RELATED Gene-based [] synonym: "lymphocyte antigen 49d" EXACT [] synonym: "T-cell surface glycoprotein Ly-49D" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000009623 name: killer cell lectin-like receptor 8 namespace: protein def: "A protein that is a translation product of the mouse Klra8 gene or a 1:1 ortholog thereof." [PRO:DNx] comment: Category=gene. Requested by=CL. synonym: "Klra8" EXACT PRO-short-label [PRO:DNx] synonym: "ly-49h" EXACT [] synonym: "Ly49-h" RELATED Gene-based [] synonym: "Ly49H" RELATED Gene-based [] synonym: "lymphocyte antigen 49h" EXACT [] synonym: "T-cell surface glycoprotein Ly-49H" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000009725 name: neutrophil gelatinase-associated lipocalin namespace: protein def: "A protein that is a translation product of the human LCN2 gene or a 1:1 ortholog thereof." [PRO:DNx] comment: Category=gene. Requested by=CL. synonym: "25 kDa alpha-2-microglobulin-related subunit of MMP-9" EXACT [] synonym: "HNL" RELATED Gene-based [] synonym: "LCN2" EXACT PRO-short-label [PRO:DNx] synonym: "lipocalin-2" EXACT [] synonym: "NGAL" RELATED Gene-based [] synonym: "oncogene 24p3" EXACT [] synonym: "p25" BROAD [PRO:DNx] synonym: "SV-40-induced 24P3 protein" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000009766 name: galectin-1 namespace: protein def: "A protein that is a translation product of the human LGALS1 gene or a 1:1 ortholog thereof." [PRO:DNx] comment: Category=gene. Requested by=CL. synonym: "14 kDa laminin-binding protein" EXACT [] synonym: "14 kDa lectin" EXACT [] synonym: "beta-galactoside-binding lectin L-14-I" EXACT [] synonym: "gal-1" EXACT [] synonym: "galaptin" EXACT [] synonym: "Gbp" RELATED Gene-based [] synonym: "HBL" EXACT [] synonym: "HLBP14" EXACT [] synonym: "HPL" EXACT [] synonym: "lactose-binding lectin 1" EXACT [] synonym: "lectin galactoside-binding soluble 1" EXACT [] synonym: "LGALS1" EXACT PRO-short-label [PRO:DNx] synonym: "putative MAPK-activating protein PM12" EXACT [] synonym: "S-Lac lectin 1" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000009793 name: LIM/homeobox protein Lhx3 namespace: protein def: "A protein that is a translation product of the human LHX3 gene or a 1:1 ortholog thereof." [PRO:DNx] comment: Category=gene. synonym: "homeobox protein LIM-3" EXACT [] synonym: "homeobox protein P-LIM" EXACT [] synonym: "LHX3" EXACT PRO-short-label [PRO:DNx] synonym: "LIM homeobox protein 3" EXACT [] synonym: "Lim-3" RELATED Gene-based [] synonym: "Lim3" RELATED Gene-based [] synonym: "Plim" RELATED Gene-based [] is_a: PR:000000001 ! protein [Term] id: PR:000009978 name: lactotransferrin namespace: protein def: "A protein that is a translation product of the human LTF gene or a 1:1 ortholog thereof." [PRO:DNx] comment: Category=gene. Requested by=CL. synonym: "GIG12" RELATED Gene-based [] synonym: "lactoferrin" EXACT [] synonym: "LF" RELATED Gene-based [] synonym: "LTF" EXACT PRO-short-label [PRO:DNx] synonym: "talalactoferrin" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000009981 name: lumican namespace: protein def: "A protein that is a translation product of the human LUM gene or a 1:1 ortholog thereof." [PRO:DNx] comment: Category=gene. synonym: "keratan sulfate proteoglycan lumican" EXACT [] synonym: "KSPG lumican" EXACT [] synonym: "Lcn" RELATED Gene-based [] synonym: "LDC" RELATED Gene-based [] synonym: "LUM" EXACT PRO-short-label [PRO:DNx] synonym: "SLRR2D" RELATED Gene-based [] is_a: PR:000000001 ! protein [Term] id: PR:000010317 name: homeobox protein Meis2 namespace: protein def: "A protein that is a translation product of the human MEIS2 gene or a 1:1 ortholog thereof." [PRO:DNx] comment: Category=gene. synonym: "Meis1-related protein 1" EXACT [] synonym: "MEIS2" EXACT PRO-short-label [PRO:DNx] synonym: "MRG1" RELATED Gene-based [] synonym: "Stra10" RELATED Gene-based [] is_a: PR:000000001 ! protein [Term] id: PR:000010329 name: tyrosine-protein kinase Mer namespace: protein def: "A protein that is a translation product of the human MERTK gene or a 1:1 ortholog thereof." [PRO:DNx] comment: Category=gene. Requested by=CL. synonym: "MER" RELATED Gene-based [] synonym: "MERTK" EXACT PRO-short-label [PRO:DNx] synonym: "proto-oncogene c-Mer" EXACT [] synonym: "proto-oncogene tyrosine-protein kinase MER" EXACT [] synonym: "receptor tyrosine kinase MerTK" EXACT [] xref: IUPHARobj:1837 is_a: PR:000000001 ! protein [Term] id: PR:000010529 name: DBH-like monooxygenase protein 1 namespace: protein def: "A protein that is a translation product of the human MOXD1 gene or a 1:1 ortholog thereof." [PRO:DNx] comment: Category=gene. synonym: "DBH-related protein" EXACT [] synonym: "Dbhr" RELATED Gene-based [] synonym: "monooxygenase X" EXACT [] synonym: "MOX" RELATED Gene-based [] synonym: "MOXD1" EXACT PRO-short-label [PRO:DNx] synonym: "UNQ2493/PRO5780" RELATED Gene-based [] is_a: PR:000000001 ! protein [Term] id: PR:000010543 name: myeloperoxidase namespace: protein def: "A protein that is a translation product of the human MPO gene or a 1:1 ortholog thereof." [PRO:DNx] comment: Category=gene. Requested by=CL. synonym: "MPO" EXACT PRO-short-label [PRO:DNx] xref: IUPHARobj:2789 is_a: CHEBI:36080 [Term] id: PR:000010799 name: myb proto-oncogene protein namespace: protein def: "A protein that is a translation product of the human MYB gene or a 1:1 ortholog thereof." [PRO:DNx] comment: Category=gene. Requested by=CL. synonym: "MYB" EXACT PRO-short-label [PRO:DNx] synonym: "proto-oncogene c-Myb" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000011118 name: neurofilament heavy polypeptide namespace: protein def: "A protein that is a translation product of the human NEFH gene or a 1:1 ortholog thereof." [PRO:DNx] comment: Category=gene. synonym: "200 kDa neurofilament protein" EXACT [] synonym: "KIAA0845" RELATED Gene-based [] synonym: "NEFH" EXACT PRO-short-label [PRO:DNx] synonym: "neurofilament triplet H protein" EXACT [] synonym: "NF-H" EXACT [] synonym: "NFH" RELATED Gene-based [] is_a: PR:000000001 ! protein [Term] id: PR:000011143 name: neuropilin and tolloid-like protein 1 namespace: protein def: "A protein that is a translation product of the human NETO1 gene or a 1:1 ortholog thereof." [PRO:DNx] comment: Category=gene. synonym: "brain-specific transmembrane protein containing 2 CUB and 1 LDL-receptor class A domains protein 1" EXACT [] synonym: "BTCL1" RELATED Gene-based [] synonym: "NETO1" EXACT PRO-short-label [PRO:DNx] is_a: PR:000000001 ! protein [Term] id: PR:000011178 name: nuclear factor NF-kappa-B p100 subunit namespace: protein def: "A transcription factor NF-kappa-B subunit that is a translation product of the human NFKB2 gene or a 1:1 ortholog thereof." [PRO:DNx] comment: Category=gene. Requested by=CL. synonym: "DNA-binding factor KBF2" EXACT [] synonym: "H2TF1" EXACT [] synonym: "lymphocyte translocation chromosome 10 protein" EXACT [] synonym: "LYT10" RELATED Gene-based [] synonym: "lyt10" EXACT [] synonym: "NFKB2" EXACT PRO-short-label [PRO:DNx] synonym: "nuclear factor of kappa light polypeptide gene enhancer in B-cells 2" EXACT [] synonym: "oncogene Lyt-10" EXACT [] is_a: PR:000001753 ! transcription factor NF-kappa-B subunit [Term] id: PR:000011241 name: homeobox protein Nkx-2.1 namespace: protein def: "A protein that is a translation product of the human NKX2-1 gene or a 1:1 ortholog thereof." [PRO:DNx] comment: Category=gene. synonym: "homeobox protein NK-2 homolog A" EXACT [] synonym: "Nkx-2.1" RELATED Gene-based [] synonym: "NKX2-1" EXACT PRO-short-label [PRO:DNx] synonym: "NKX2A" RELATED Gene-based [] synonym: "T/EBP" EXACT [] synonym: "thyroid nuclear factor 1" EXACT [] synonym: "thyroid transcription factor 1" EXACT [] synonym: "thyroid-specific enhancer-binding protein" EXACT [] synonym: "TITF1" RELATED Gene-based [] synonym: "TTF-1" RELATED [] synonym: "TTF1" RELATED Gene-based [] is_a: PR:000000001 ! protein [Term] id: PR:000011326 name: nitric oxide synthase 1 namespace: protein def: "A protein that is a translation product of the human NOS1 gene or a 1:1 ortholog thereof." [PRO:DNx] comment: Category=gene. synonym: "bNOS" EXACT [] synonym: "constitutive NOS" BROAD [PRO:DNx] synonym: "N-NOS" EXACT [] synonym: "NC-NOS" EXACT [] synonym: "neuronal NOS" EXACT [] synonym: "nitric oxide synthase, brain" EXACT [] synonym: "nNOS" EXACT [] synonym: "NOS type I" EXACT [] synonym: "NOS1" EXACT PRO-short-label [PRO:DNx] synonym: "peptidyl-cysteine S-nitrosylase NOS1" EXACT [] xref: IUPHARobj:1251 is_a: PR:000000001 ! protein [Term] id: PR:000011387 name: neuropeptide Y namespace: protein def: "A protein that is a translation product of the human NPY gene or a 1:1 ortholog thereof." [PRO:DNx] comment: Category=gene. synonym: "NPY" EXACT PRO-short-label [PRO:DNx] is_a: PR:000000001 ! protein [Term] id: PR:000011467 name: netrin-G1 namespace: protein def: "A protein that is a translation product of the human NTNG1 gene or a 1:1 ortholog thereof." [PRO:DNx] comment: Category=gene. synonym: "KIAA0976" RELATED Gene-based [] synonym: "laminet-1" EXACT [] synonym: "LMNT1" RELATED Gene-based [] synonym: "NTNG1" EXACT PRO-short-label [PRO:DNx] synonym: "UNQ571/PRO1133" RELATED Gene-based [] is_a: PR:000000001 ! protein [Term] id: PR:000012190 name: P2X purinoceptor 3 namespace: protein def: "A P2X receptor protein that is a translation product of the human P2RX3 gene or a 1:1 ortholog thereof." [PRO:DNx] comment: Category=gene. synonym: "ATP receptor" BROAD [PRO:DNx] synonym: "P2RX3" EXACT PRO-short-label [PRO:DNx] synonym: "P2X3" EXACT [] synonym: "purinergic receptor" BROAD [PRO:DNx] xref: IUPHARobj:480 is_a: PR:000044669 ! P2X receptor protein [Term] id: PR:000012318 name: paired box protein Pax-6 namespace: protein def: "A paired box protein PAX group IV that is a translation product of the human PAX6 gene or a 1:1 ortholog thereof." [PRO:DNx] comment: Category=gene. synonym: "AN2" RELATED Gene-based [] synonym: "aniridia type II protein" EXACT [] synonym: "oculorhombin" EXACT [] synonym: "Pax-6" RELATED Gene-based [] synonym: "PAX6" EXACT PRO-short-label [PRO:DNx] synonym: "Sey" RELATED Gene-based [] is_a: PR:000037798 ! paired box protein PAX group IV [Term] id: PR:000012526 name: proenkephalin-B namespace: protein def: "A protein that is a translation product of the human PDYN gene or a 1:1 ortholog thereof." [PRO:DNx] comment: Category=gene. synonym: "beta-neoendorphin-dynorphin" EXACT [] synonym: "PDYN" EXACT PRO-short-label [PRO:DNx] synonym: "preprodynorphin" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000012544 name: proenkephalin-A namespace: protein def: "A protein that is a translation product of the human PENK gene or a 1:1 ortholog thereof." [PRO:DNx] comment: Category=gene. synonym: "PENK" EXACT PRO-short-label [PRO:DNx] synonym: "Penk1" RELATED Gene-based [] is_a: PR:000000001 ! protein [Term] id: PR:000013015 name: pro-opiomelanocortin namespace: protein def: "A protein that is a translation product of the human POMC gene or a 1:1 ortholog thereof." [PRO:DNx] comment: Category=gene. synonym: "corticotropin-lipotropin" EXACT [] synonym: "POMC" EXACT PRO-short-label [PRO:DNx] synonym: "Pomc1" RELATED Gene-based [] is_a: PR:000000001 ! protein [Term] id: PR:000013031 name: periostin namespace: protein def: "A protein that is a translation product of the human POSTN gene or a 1:1 ortholog thereof." [PRO:DNx] comment: Category=gene. synonym: "OSF-2" RELATED [] synonym: "OSF2" RELATED Gene-based [] synonym: "osteoblast-specific factor 2" EXACT [] synonym: "PN" EXACT [] synonym: "POSTN" EXACT PRO-short-label [PRO:DNx] is_a: PR:000000001 ! protein [Term] id: PR:000013041 name: POU domain, class 4, transcription factor 1 namespace: protein def: "A protein that is a translation product of the human POU4F1 gene or a 1:1 ortholog thereof." [PRO:DNx] comment: Category=gene. synonym: "brain-3A" EXACT [] synonym: "brain-specific homeobox/POU domain protein 3A" EXACT [] synonym: "Brn-3" RELATED Gene-based [] synonym: "Brn-3.0" EXACT [] synonym: "Brn-3A" EXACT [] synonym: "Brn3" RELATED Gene-based [] synonym: "BRN3A" RELATED Gene-based [] synonym: "homeobox/POU domain protein RDC-1" EXACT [] synonym: "Oct-T1" EXACT [] synonym: "POU4F1" EXACT PRO-short-label [PRO:DNx] synonym: "RDC1" RELATED Gene-based [] is_a: PR:000000001 ! protein [Term] id: PR:000013047 name: POU domain, class 6, transcription factor 2 namespace: protein def: "A protein that is a translation product of the human POU6F2 gene or a 1:1 ortholog thereof." [PRO:DNx] comment: Category=gene. synonym: "POU6F2" EXACT PRO-short-label [PRO:DNx] synonym: "retina-derived POU domain factor 1" EXACT [] synonym: "RPF-1" EXACT [] synonym: "RPF1" RELATED Gene-based [] is_a: PR:000000001 ! protein [Term] id: PR:000013206 name: bone marrow proteoglycan namespace: protein def: "A protein that is a translation product of the human PRG2 gene or a 1:1 ortholog thereof." [PRO:DNx] comment: Category=gene. synonym: "BMPG" EXACT [] synonym: "MBP" RELATED Gene-based [] synonym: "Mbp-1" RELATED Gene-based [] synonym: "PRG2" EXACT PRO-short-label [PRO:DNx] synonym: "proteoglycan 2" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000013246 name: prolactin namespace: protein def: "A somatotropin hormone family member that is a translation product of the human PRL gene or a 1:1 ortholog thereof." [PRO:DNx] comment: Category=gene. synonym: "PRL" EXACT PRO-short-label [PRO:DNx] is_a: PR:000029968 ! somatotropin hormone family member [Term] id: PR:000013289 name: peripherin namespace: protein def: "A protein that is a translation product of the human PRPH gene or a 1:1 ortholog thereof." [PRO:DNx] comment: Category=gene. synonym: "NEF4" RELATED Gene-based [] synonym: "neurofilament 4" EXACT [] synonym: "PRPH" EXACT PRO-short-label [PRO:DNx] synonym: "PRPH1" RELATED Gene-based [] is_a: PR:000000001 ! protein [Term] id: PR:000013433 name: parathyroid hormone-related protein namespace: protein def: "A protein that is a translation product of the human PTHLH gene or a 1:1 ortholog thereof." [PRO:DNx] comment: Category=gene. synonym: "parathyroid hormone-like protein" EXACT [] synonym: "PLP" RELATED [] synonym: "PTH-rP" EXACT [] synonym: "PTHLH" EXACT PRO-short-label [PRO:DNx] synonym: "PTHRP" RELATED Gene-based [] synonym: "PTHrP" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000013502 name: parvalbumin alpha namespace: protein def: "A protein that is a translation product of the human PVALB gene or a 1:1 ortholog thereof." [PRO:DNx] comment: Category=gene. synonym: "Pva" RELATED Gene-based [] synonym: "PVALB" EXACT PRO-short-label [PRO:DNx] is_a: PR:000000001 ! protein [Term] id: PR:000013879 name: reelin namespace: protein def: "A protein that is a translation product of the human RELN gene or a 1:1 ortholog thereof." [PRO:DNx] comment: Category=gene. synonym: "reeler protein" EXACT [] synonym: "RELN" EXACT PRO-short-label [PRO:DNx] synonym: "Rl" RELATED Gene-based [] is_a: PR:000000001 ! protein [Term] id: PR:000013883 name: renin namespace: protein def: "An angiotensinogenase that is a translation product of the human REN gene or a 1:1 ortholog thereof." [PRO:DAN] comment: Category=gene. synonym: "angiotensinogenase" RELATED [] synonym: "REN" EXACT PRO-short-label [PRO:DNx] xref: IUPHARobj:2413 is_a: PR:000050025 ! angiotensinogenase [Term] id: PR:000013895 name: proto-oncogene tyrosine-protein kinase receptor Ret namespace: protein def: "A protein that is a translation product of the human RET gene or a 1:1 ortholog thereof." [PRO:DNx] comment: Category=gene. synonym: "cadherin family member 12" EXACT [] synonym: "CDHF12" RELATED Gene-based [] synonym: "CDHR16" RELATED Gene-based [] synonym: "proto-oncogene c-Ret" EXACT [] synonym: "PTC" RELATED Gene-based [] synonym: "RET" EXACT PRO-short-label [PRO:DNx] synonym: "RET51" RELATED Gene-based [] xref: IUPHARobj:2185 is_a: PR:000000001 ! protein [Term] id: PR:000014046 name: non-secretory ribonuclease namespace: protein def: "A protein that is a translation product of the human RNASE2 gene or a 1:1 ortholog thereof." [PRO:DNx] comment: Category=gene. Requested by=CL. synonym: "Ear4" RELATED [] synonym: "EDN" RELATED Gene-based [] synonym: "eosinophil cationic-type ribonuclease 4" EXACT [] synonym: "eosinophil-derived neurotoxin" EXACT [] synonym: "MR-4" EXACT [] synonym: "ribonuclease 2" EXACT [] synonym: "ribonuclease US" EXACT [] synonym: "RNase 2" EXACT [] synonym: "RNase UpI-2" EXACT [] synonym: "RNASE2" EXACT PRO-short-label [PRO:DNx] synonym: "RNS2" RELATED Gene-based [] is_a: PR:000000001 ! protein [Term] id: PR:000014047 name: eosinophil cationic protein namespace: protein def: "A protein that is a translation product of the human RNASE3 gene or a 1:1 ortholog thereof." [PRO:DNx] comment: Category=gene. Requested by=CL. synonym: "ECP" RELATED Gene-based [] synonym: "ribonuclease 3" RELATED [] synonym: "RNase 3" EXACT [] synonym: "RNASE3" EXACT PRO-short-label [PRO:DNx] synonym: "RNS3" RELATED Gene-based [] is_a: PR:000000001 ! protein [Term] id: PR:000014362 name: runt-related transcription factor 1 namespace: protein def: "A protein that is a translation product of the human RUNX1 gene or a 1:1 ortholog thereof." [PRO:DNx] comment: Category=gene. Requested by=CL. synonym: "acute myeloid leukemia 1 protein" EXACT [] synonym: "AML1" RELATED Gene-based [] synonym: "CBF-alpha-2" EXACT [] synonym: "CBFA2" RELATED Gene-based [] synonym: "core-binding factor subunit alpha-2" EXACT [] synonym: "oncogene AML-1" EXACT [] synonym: "PEA2-alpha B" EXACT [] synonym: "PEBP2-alpha B" EXACT [] synonym: "Pebp2ab" RELATED Gene-based [] synonym: "polyomavirus enhancer-binding protein 2 alpha B subunit" EXACT [] synonym: "RUNX1" EXACT PRO-short-label [PRO:DNx] synonym: "SL3-3 enhancer factor 1 alpha B subunit" EXACT [] synonym: "SL3/AKV core-binding factor alpha B subunit" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000014419 name: protein S100-B namespace: protein def: "A protein that is a translation product of the human S100B gene or a 1:1 ortholog thereof." [PRO:DNx] comment: Category=gene. synonym: "S-100 protein beta chain" EXACT [] synonym: "S-100 protein subunit beta" EXACT [] synonym: "S100 calcium-binding protein B" EXACT [] synonym: "S100B" EXACT PRO-short-label [PRO:DNx] is_a: PR:000000001 ! protein [Term] id: PR:000014505 name: uteroglobin namespace: protein def: "A protein that is a translation product of the human SCGB1A1 gene or a 1:1 ortholog thereof." [PRO:DNx] comment: Category=gene. synonym: "CC10" RELATED Gene-based [] synonym: "CCPBP" EXACT [] synonym: "CCSP" RELATED Gene-based [] synonym: "clara cell 17 kDa protein" EXACT [] synonym: "clara cell phospholipid-binding protein" EXACT [] synonym: "clara cells 10 kDa secretory protein" EXACT [] synonym: "Club cell phospholipid-binding protein" EXACT [] synonym: "Club cells 10 kDa secretory protein" EXACT [] synonym: "PCB-binding protein" EXACT [] synonym: "SCGB1A1" EXACT PRO-short-label [PRO:DNx] synonym: "secretoglobin family 1A member 1" EXACT [] synonym: "UGB" RELATED Gene-based [] synonym: "UP-1" EXACT [] synonym: "UP1" EXACT [] synonym: "urinary protein 1" EXACT [] synonym: "urine protein 1" EXACT [] synonym: "Utg" RELATED Gene-based [] is_a: PR:000000001 ! protein [Term] id: PR:000014841 name: sonic hedgehog protein namespace: protein def: "A protein that is a translation product of the human SHH gene or a 1:1 ortholog thereof." [PRO:DNx] comment: Category=gene. synonym: "HHG-1" EXACT [] synonym: "Hhg1" RELATED Gene-based [] synonym: "SHH" EXACT PRO-short-label [PRO:DNx] synonym: "Shh unprocessed N-terminal signaling and C-terminal autoprocessing domains" EXACT [] synonym: "ShhNC" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000014898 name: homeobox protein SIX3 namespace: protein def: "A protein that is a translation product of the human SIX3 gene or a 1:1 ortholog thereof." [PRO:DNx] comment: Category=gene. synonym: "sine oculis homeobox homolog 3" EXACT [] synonym: "SIX3" EXACT PRO-short-label [PRO:DNx] is_a: PR:000000001 ! protein [Term] id: PR:000014962 name: vesicular glutamate transporter 2 namespace: protein def: "A protein that is a translation product of the human SLC17A6 gene or a 1:1 ortholog thereof." [PRO:DNx] comment: Category=gene. synonym: "differentiation-associated BNPI" EXACT [] synonym: "differentiation-associated Na(+)-dependent inorganic phosphate cotransporter" EXACT [] synonym: "DNPI" RELATED Gene-based [] synonym: "SLC17A6" EXACT PRO-short-label [PRO:DNx] synonym: "solute carrier family 17 member 6" EXACT [] synonym: "VGLUT2" RELATED Gene-based [] synonym: "VGluT2" EXACT [] xref: IUPHARobj:1008 is_a: PR:000000001 ! protein [Term] id: PR:000014968 name: vesicular acetylcholine transporter namespace: protein def: "A protein that is a translation product of the human SLC18A3 gene or a 1:1 ortholog thereof." [PRO:DNx] comment: Category=gene. synonym: "SLC18A3" EXACT PRO-short-label [PRO:DNx] synonym: "solute carrier family 18 member 3" EXACT [] synonym: "VACHT" RELATED Gene-based [] synonym: "VAChT" EXACT [] xref: IUPHARobj:1013 is_a: PR:000000001 ! protein [Term] id: PR:000015325 name: gamma-synuclein namespace: protein def: "A protein that is a translation product of the human SNCG gene or a 1:1 ortholog thereof." [PRO:DNx] comment: Category=gene. synonym: "BCSG1" RELATED Gene-based [] synonym: "breast cancer-specific gene 1 protein" EXACT [] synonym: "PERSYN" RELATED Gene-based [] synonym: "persyn" EXACT [] synonym: "PRSN" RELATED Gene-based [] synonym: "SNCG" EXACT PRO-short-label [PRO:DNx] synonym: "SR" EXACT [] synonym: "synoretin" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000015426 name: transcription factor SOX-2 namespace: protein def: "A protein that is a translation product of the human SOX2 gene or a 1:1 ortholog thereof." [PRO:DNx] comment: Category=gene. synonym: "Sox-2" RELATED Gene-based [] synonym: "SOX2" EXACT PRO-short-label [PRO:DNx] is_a: PR:000000001 ! protein [Term] id: PR:000015476 name: SPARC-like protein 1 namespace: protein def: "A protein that is a translation product of the human SPARCL1 gene or a 1:1 ortholog thereof." [PRO:DNx] comment: Category=gene. synonym: "Ecm2" RELATED Gene-based [] synonym: "extracellular matrix protein 2" RELATED [] synonym: "hevin" EXACT [] synonym: "high endothelial venule protein" EXACT [] synonym: "MAST 9" EXACT [] synonym: "matrix glycoprotein Sc1" EXACT [] synonym: "Sc1" RELATED Gene-based [] synonym: "SPARCL1" EXACT PRO-short-label [PRO:DNx] is_a: PR:000000001 ! protein [Term] id: PR:000015557 name: spondin-1 namespace: protein def: "A protein that is a translation product of the human SPON1 gene or a 1:1 ortholog thereof." [PRO:DNx] comment: Category=gene. synonym: "F-spondin" EXACT [] synonym: "KIAA0762" RELATED Gene-based [] synonym: "SPON1" EXACT PRO-short-label [PRO:DNx] synonym: "vascular smooth muscle cell growth-promoting factor" EXACT [] synonym: "VSGP" RELATED Gene-based [] is_a: PR:000000001 ! protein [Term] id: PR:000015658 name: SCO-spondin namespace: protein def: "A protein that is a translation product of the human SSPO gene or a 1:1 ortholog thereof." [PRO:DNx] comment: Category=gene. synonym: "KIAA2036" RELATED Gene-based [] synonym: "SSPO" EXACT PRO-short-label [PRO:DNx] synonym: "SSPOP" RELATED Gene-based [] is_a: PR:000000001 ! protein [Term] id: PR:000015665 name: somatostatin namespace: protein def: "A protein that is a translation product of the human SST gene or a 1:1 ortholog thereof." [PRO:DNx] comment: Category=gene. synonym: "growth hormone release-inhibiting factor" EXACT [] synonym: "Smst" RELATED Gene-based [] synonym: "SST" EXACT PRO-short-label [PRO:DNx] is_a: PR:000000001 ! protein [Term] id: PR:000016004 name: tachykinin-3 namespace: protein def: "A protein that is a translation product of the human TAC3 gene or a 1:1 ortholog thereof." [PRO:DNx] comment: Category=gene. synonym: "neurokinin B-like protein Zneurok1" EXACT [] synonym: "NKNB" RELATED Gene-based [] synonym: "PPT-B" EXACT [] synonym: "preprotachykinin-B" EXACT [] synonym: "Tac2" RELATED Gene-based [] synonym: "TAC3" EXACT PRO-short-label [PRO:DNx] synonym: "UNQ585/PRO1155" RELATED Gene-based [] synonym: "ZNEUROK1" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000016043 name: T-cell acute lymphocytic leukemia protein 1 namespace: protein def: "A protein that is a translation product of the human TAL1 gene or a 1:1 ortholog thereof." [PRO:DNx] comment: Category=gene. Requested by=CL. synonym: "BHLHA17" RELATED Gene-based [] synonym: "bHLHa17" EXACT [] synonym: "class A basic helix-loop-helix protein 17" EXACT [] synonym: "SCL" RELATED Gene-based [] synonym: "stem cell protein" EXACT [] synonym: "T-cell leukemia/lymphoma protein 5" EXACT [] synonym: "TAL-1" EXACT [] synonym: "TAL1" EXACT PRO-short-label [PRO:DNx] synonym: "TCL5" RELATED Gene-based [] is_a: PR:000000001 ! protein [Term] id: PR:000016301 name: tyrosine 3-monooxygenase namespace: protein def: "A protein that is a translation product of the human TH gene or a 1:1 ortholog thereof." [PRO:DNx] comment: Category=gene. synonym: "TH" EXACT PRO-short-label [PRO:DNx] synonym: "TYH" RELATED Gene-based [] synonym: "tyrosine 3-hydroxylase" EXACT [] xref: IUPHARobj:1243 is_a: PR:000000001 ! protein [Term] id: PR:000016401 name: transmembrane emp24 domain-containing protein 1 namespace: protein def: "A protein that is a translation product of the human TMED1 gene or a 1:1 ortholog thereof." [PRO:DNx] comment: Category=gene. Requested by=CL. synonym: "IL1RL1L" RELATED Gene-based [] synonym: "IL1RL1LG" RELATED Gene-based [] synonym: "interleukin-1 receptor-like 1 ligand" EXACT [] synonym: "p24 family protein gamma-1" EXACT [] synonym: "p24gamma1" EXACT [] synonym: "putative T1/ST2 receptor-binding protein" EXACT [] synonym: "TMED1" EXACT PRO-short-label [PRO:DNx] is_a: PR:000000001 ! protein [Term] id: PR:000016407 name: tomoregulin-2 namespace: protein def: "A protein that is a translation product of the human TMEFF2 gene or a 1:1 ortholog thereof." [PRO:DNx] comment: Category=gene. synonym: "HPP1" RELATED Gene-based [] synonym: "hyperplastic polyposis protein 1" EXACT [] synonym: "TENB2" RELATED Gene-based [] synonym: "TMEFF2" EXACT PRO-short-label [PRO:DNx] synonym: "TPEF" RELATED Gene-based [] synonym: "TR-2" EXACT [] synonym: "transmembrane protein with EGF-like and two follistatin-like domains" EXACT [] synonym: "UNQ178/PRO204" RELATED Gene-based [] is_a: PR:000000001 ! protein [Term] id: PR:000016626 name: triggering receptor expressed on myeloid cells 2 namespace: protein def: "A protein that is a translation product of the human TREM2 gene or a 1:1 ortholog thereof." [PRO:DNx] comment: Category=gene. synonym: "TREM-2" EXACT [] synonym: "TREM2" EXACT PRO-short-label [PRO:DNx] synonym: "Trem2a" RELATED Gene-based [] synonym: "Trem2b" RELATED Gene-based [] synonym: "Trem2c" RELATED Gene-based [] synonym: "triggering receptor expressed on monocytes 2" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000017298 name: vimentin namespace: protein def: "A protein that is a translation product of the human VIM gene or a 1:1 ortholog thereof." [PRO:DNx] comment: Category=gene. synonym: "VIM" EXACT PRO-short-label [PRO:DNx] is_a: PR:000000001 ! protein [Term] id: PR:000017299 name: VIP peptides namespace: protein def: "A protein that is a translation product of the human VIP gene or a 1:1 ortholog thereof." [PRO:DNx] comment: Category=gene. synonym: "vasoactive intestinal peptides" EXACT [PRO:DNx] synonym: "vasoactive intestinal polypeptides" EXACT [PRO:DNx] synonym: "vasoactive intestinal polypeptides precursor" EXACT [] synonym: "VIP" EXACT PRO-short-label [PRO:DNx] is_a: PR:000000001 ! protein [Term] id: PR:000018263 name: amino acid chain namespace: protein def: "A molecule that consists of amino acid residues (unmodified amino-acid residues and/or modified amino-acid residues) linked by peptide bonds or derivatives of such bonds." [PRO:DAN, PRO:JSG] comment: Category=polymer. synonym: "peptide" NARROW [PRO:DAN] synonym: "polypeptide" NARROW [PRO:DAN] is_a: COB:0000013 relationship: RO:0020337 CHEBI:33708 relationship: RO:0020337 CHEBI:33708 {minCardinality="2"} [Term] id: PR:000018264 name: proteolytic cleavage product namespace: protein def: "A protein that is produced as the result of proteolytic processing of a longer protein." [PRO:DAN] synonym: "ClvPrd" EXACT PRO-short-label [PRO:DAN] synonym: "peptide" NARROW [PRO:DAN] synonym: "polypeptide" NARROW [PRO:DAN] is_a: CHEBI:36080 is_a: PR:000000001 ! protein intersection_of: PR:000000001 ! protein intersection_of: RO:0002353 GO:0016485 ! output of protein processing relationship: RO:0002353 GO:0016485 ! output of protein processing [Term] id: PR:000018311 name: integrin alpha-E proteolytic cleavage product namespace: protein def: "An integrin alpha-E that has been processed by proteolytic cleavage." [PRO:DNx] comment: Category=modification. synonym: "ITGAE/ClvPrd" EXACT PRO-short-label [PRO:DNx] is_a: PR:000001010 ! integrin alpha-E is_a: PR:000018264 ! proteolytic cleavage product intersection_of: PR:000001010 ! integrin alpha-E intersection_of: RO:0002353 GO:0016485 ! output of protein processing [Term] id: PR:000018335 name: T-cell surface glycoprotein CD8 alpha chain, signal peptide removed form namespace: protein def: "A T-cell surface glycoprotein CD8 alpha chain that has had the signal peptide removed." [PRO:DNx] comment: Category=modification. synonym: "CD8A/SigPep-" EXACT PRO-short-label [PRO:DNx] is_a: PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain [Term] id: PR:000018337 name: T-cell surface glycoprotein CD8 beta chain, signal peptide removed form namespace: protein def: "A T-cell surface glycoprotein CD8 beta chain that has had the signal peptide removed." [PRO:DNx] comment: Category=modification. synonym: "CD8B/SigPep-" EXACT PRO-short-label [PRO:DNx] is_a: PR:000001085 ! T-cell surface glycoprotein CD8 beta chain [Term] id: PR:000018381 name: CD48 molecule proteolytic cleavage product namespace: protein def: "A CD48 molecule that has been processed by proteolytic cleavage." [PRO:DNx] comment: Category=modification. synonym: "CD48/ClvPrd" EXACT PRO-short-label [PRO:DNx] is_a: PR:000001308 ! CD48 molecule is_a: PR:000018264 ! proteolytic cleavage product intersection_of: PR:000001308 ! CD48 molecule intersection_of: RO:0002353 GO:0016485 ! output of protein processing [Term] id: PR:000018390 name: L-selectin proteolytic cleavage product namespace: protein def: "An L-selectin that has been processed by proteolytic cleavage." [PRO:DNx] comment: Category=modification. synonym: "SELL/ClvPrd" EXACT PRO-short-label [PRO:DNx] is_a: PR:000001318 ! L-selectin is_a: PR:000018264 ! proteolytic cleavage product intersection_of: PR:000001318 ! L-selectin intersection_of: RO:0002353 GO:0016485 ! output of protein processing [Term] id: PR:000018406 name: cell adhesion molecule CEACAM8 proteolytic cleavage product namespace: protein def: "A cell adhesion molecule CEACAM8 that has been processed by proteolytic cleavage." [PRO:DNx] comment: Category=modification. synonym: "CEACAM8/ClvPrd" EXACT PRO-short-label [PRO:DNx] is_a: PR:000001332 ! cell adhesion molecule CEACAM8 is_a: PR:000018264 ! proteolytic cleavage product intersection_of: PR:000001332 ! cell adhesion molecule CEACAM8 intersection_of: RO:0002353 GO:0016485 ! output of protein processing [Term] id: PR:000018481 name: cadherin-1 proteolytic cleavage product namespace: protein def: "A cadherin-1 that has been processed by proteolytic cleavage." [PRO:DNx] comment: Category=modification. synonym: "CDH1/ClvPrd" EXACT PRO-short-label [PRO:DNx] is_a: PR:000001447 ! cadherin-1 is_a: PR:000018264 ! proteolytic cleavage product intersection_of: PR:000001447 ! cadherin-1 intersection_of: RO:0002353 GO:0016485 ! output of protein processing [Term] id: PR:000018546 name: Thy-1 membrane glycoprotein proteolytic cleavage product namespace: protein def: "A Thy-1 membrane glycoprotein that has been processed by proteolytic cleavage." [PRO:DNx] comment: Category=modification. synonym: "THY1/ClvPrd" EXACT PRO-short-label [PRO:DNx] is_a: PR:000001843 ! Thy-1 membrane glycoprotein is_a: PR:000018264 ! proteolytic cleavage product intersection_of: PR:000001843 ! Thy-1 membrane glycoprotein intersection_of: RO:0002353 GO:0016485 ! output of protein processing [Term] id: PR:000018547 name: cathepsin K proteolytic cleavage product namespace: protein def: "A cathepsin K that has been processed by proteolytic cleavage." [PRO:DNx] comment: Category=modification. synonym: "CTSK/ClvPrd" EXACT PRO-short-label [PRO:DNx] is_a: PR:000001850 ! cathepsin K is_a: PR:000018264 ! proteolytic cleavage product intersection_of: PR:000001850 ! cathepsin K intersection_of: RO:0002353 GO:0016485 ! output of protein processing [Term] id: PR:000018568 name: low affinity immunoglobulin epsilon Fc receptor proteolytic cleavage product namespace: protein def: "A low affinity immunoglobulin epsilon Fc receptor that has been processed by proteolytic cleavage." [PRO:DNx] comment: Category=modification. synonym: "FCER2/ClvPrd" EXACT PRO-short-label [PRO:DNx] is_a: PR:000001880 ! low affinity immunoglobulin epsilon Fc receptor is_a: PR:000018264 ! proteolytic cleavage product intersection_of: PR:000001880 ! low affinity immunoglobulin epsilon Fc receptor intersection_of: RO:0002353 GO:0016485 ! output of protein processing [Term] id: PR:000018591 name: platelet glycoprotein Ib alpha chain proteolytic cleavage product namespace: protein def: "A platelet glycoprotein Ib alpha chain that has been processed by proteolytic cleavage." [PRO:DNx] comment: Category=modification. synonym: "GP1BA/ClvPrd" EXACT PRO-short-label [PRO:DNx] is_a: PR:000001907 ! platelet glycoprotein Ib alpha chain is_a: PR:000018264 ! proteolytic cleavage product intersection_of: PR:000001907 ! platelet glycoprotein Ib alpha chain intersection_of: RO:0002353 GO:0016485 ! output of protein processing [Term] id: PR:000018594 name: scavenger receptor cysteine-rich type 1 protein M130 proteolytic cleavage product namespace: protein def: "A scavenger receptor cysteine-rich type 1 protein M130 that has been processed by proteolytic cleavage." [PRO:DNx] comment: Category=modification. synonym: "CD163/ClvPrd" EXACT PRO-short-label [PRO:DNx] is_a: PR:000001925 ! scavenger receptor cysteine-rich type 1 protein M130 is_a: PR:000018264 ! proteolytic cleavage product intersection_of: PR:000001925 ! scavenger receptor cysteine-rich type 1 protein M130 intersection_of: RO:0002353 GO:0016485 ! output of protein processing [Term] id: PR:000018603 name: transferrin receptor protein 1 proteolytic cleavage product namespace: protein def: "A transferrin receptor protein 1 that has been processed by proteolytic cleavage." [PRO:DNx] comment: Category=modification. synonym: "TFRC/ClvPrd" EXACT PRO-short-label [PRO:DNx] is_a: PR:000001945 ! transferrin receptor protein 1 is_a: PR:000018264 ! proteolytic cleavage product intersection_of: PR:000001945 ! transferrin receptor protein 1 intersection_of: RO:0002353 GO:0016485 ! output of protein processing [Term] id: PR:000018606 name: tumor necrosis factor ligand superfamily member 5 proteolytic cleavage product namespace: protein def: "A tumor necrosis factor ligand superfamily member 5 that has been processed by proteolytic cleavage." [PRO:DNx] comment: Category=modification. synonym: "CD40LG/ClvPrd" EXACT PRO-short-label [PRO:DNx] is_a: PR:000001950 ! tumor necrosis factor ligand superfamily member 5 is_a: PR:000018264 ! proteolytic cleavage product intersection_of: PR:000001950 ! tumor necrosis factor ligand superfamily member 5 intersection_of: RO:0002353 GO:0016485 ! output of protein processing [Term] id: PR:000018732 name: C-C motif chemokine 3 proteolytic cleavage product namespace: protein def: "A C-C motif chemokine 3 that has been processed by proteolytic cleavage." [PRO:DNx] comment: Category=modification. synonym: "CCL3/ClvPrd" EXACT PRO-short-label [PRO:DNx] is_a: PR:000002123 ! C-C motif chemokine 3 is_a: PR:000018264 ! proteolytic cleavage product intersection_of: PR:000002123 ! C-C motif chemokine 3 intersection_of: RO:0002353 GO:0016485 ! output of protein processing [Term] id: PR:000018798 name: collagen alpha-1(I) chain proteolytic cleavage product namespace: protein def: "A collagen alpha-1(I) chain that has been processed by proteolytic cleavage." [PRO:DNx] comment: Category=modification. synonym: "COL1A1/ClvPrd" EXACT PRO-short-label [PRO:DNx] is_a: PR:000003264 ! collagen alpha-1(I) chain is_a: PR:000018264 ! proteolytic cleavage product intersection_of: PR:000003264 ! collagen alpha-1(I) chain intersection_of: RO:0002353 GO:0016485 ! output of protein processing [Term] id: PR:000018809 name: collagen alpha-1(III) chain proteolytic cleavage product namespace: protein def: "A collagen alpha-1(III) chain that has been processed by proteolytic cleavage." [PRO:DNx] comment: Category=modification. synonym: "COL3A1/ClvPrd" EXACT PRO-short-label [PRO:DNx] is_a: PR:000003328 ! collagen alpha-1(III) chain is_a: PR:000018264 ! proteolytic cleavage product intersection_of: PR:000003328 ! collagen alpha-1(III) chain intersection_of: RO:0002353 GO:0016485 ! output of protein processing [Term] id: PR:000018820 name: granzyme K proteolytic cleavage product namespace: protein def: "A granzyme K that has been processed by proteolytic cleavage." [PRO:DNx] comment: Category=modification. synonym: "GZMK/ClvPrd" EXACT PRO-short-label [PRO:DNx] is_a: PR:000003472 ! granzyme K is_a: PR:000018264 ! proteolytic cleavage product intersection_of: PR:000003472 ! granzyme K intersection_of: RO:0002353 GO:0016485 ! output of protein processing [Term] id: PR:000018835 name: granzyme H proteolytic cleavage product namespace: protein def: "A granzyme H that has been processed by proteolytic cleavage." [PRO:DNx] comment: Category=modification. synonym: "GZMH/ClvPrd" EXACT PRO-short-label [PRO:DNx] is_a: PR:000003490 ! granzyme H is_a: PR:000018264 ! proteolytic cleavage product intersection_of: PR:000003490 ! granzyme H intersection_of: RO:0002353 GO:0016485 ! output of protein processing [Term] id: PR:000018883 name: actin, aortic smooth muscle proteolytic cleavage product namespace: protein def: "An actin, aortic smooth muscle that has been processed by proteolytic cleavage." [PRO:DNx] comment: Category=modification. synonym: "ACTA2/ClvPrd" EXACT PRO-short-label [PRO:DNx] is_a: PR:000003675 ! actin, aortic smooth muscle is_a: PR:000018264 ! proteolytic cleavage product intersection_of: PR:000003675 ! actin, aortic smooth muscle intersection_of: RO:0002353 GO:0016485 ! output of protein processing [Term] id: PR:000019255 name: cholecystokinin proteolytic cleavage product namespace: protein def: "A cholecystokinin that has been processed by proteolytic cleavage." [PRO:DNx] comment: Category=modification. synonym: "CCK/ClvPrd" EXACT PRO-short-label [PRO:DNx] is_a: PR:000005110 ! cholecystokinin is_a: PR:000018264 ! proteolytic cleavage product intersection_of: PR:000005110 ! cholecystokinin intersection_of: RO:0002353 GO:0016485 ! output of protein processing [Term] id: PR:000019396 name: collagen alpha-1(XI) chain proteolytic cleavage product namespace: protein def: "A collagen alpha-1(XI) chain that has been processed by proteolytic cleavage." [PRO:DNx] comment: Category=modification. synonym: "COL11A1/ClvPrd" EXACT PRO-short-label [PRO:DNx] is_a: PR:000005694 ! collagen alpha-1(XI) chain is_a: PR:000018264 ! proteolytic cleavage product intersection_of: PR:000005694 ! collagen alpha-1(XI) chain intersection_of: RO:0002353 GO:0016485 ! output of protein processing [Term] id: PR:000019644 name: dopamine beta-hydroxylase proteolytic cleavage product namespace: protein def: "A dopamine beta-hydroxylase that has been processed by proteolytic cleavage." [PRO:DNx] comment: Category=modification. synonym: "DBH/ClvPrd" EXACT PRO-short-label [PRO:DNx] is_a: PR:000006294 ! dopamine beta-hydroxylase is_a: PR:000018264 ! proteolytic cleavage product intersection_of: PR:000006294 ! dopamine beta-hydroxylase intersection_of: RO:0002353 GO:0016485 ! output of protein processing [Term] id: PR:000019700 name: dipeptidase 1 proteolytic cleavage product namespace: protein def: "A dipeptidase 1 that has been processed by proteolytic cleavage." [PRO:DNx] comment: Category=modification. synonym: "DPEP1/ClvPrd" EXACT PRO-short-label [PRO:DNx] is_a: PR:000006646 ! dipeptidase 1 is_a: PR:000018264 ! proteolytic cleavage product intersection_of: PR:000006646 ! dipeptidase 1 intersection_of: RO:0002353 GO:0016485 ! output of protein processing [Term] id: PR:000019734 name: endothelin-1 proteolytic cleavage product namespace: protein def: "An endothelin-1 that has been processed by proteolytic cleavage." [PRO:DNx] comment: Category=modification. synonym: "EDN1/ClvPrd" EXACT PRO-short-label [PRO:DNx] is_a: PR:000006897 ! endothelin-1 is_a: PR:000018264 ! proteolytic cleavage product intersection_of: PR:000006897 ! endothelin-1 intersection_of: RO:0002353 GO:0016485 ! output of protein processing [Term] id: PR:000019802 name: eosinophil peroxidase proteolytic cleavage product namespace: protein def: "An eosinophil peroxidase that has been processed by proteolytic cleavage." [PRO:DNx] comment: Category=modification. synonym: "EPX/ClvPrd" EXACT PRO-short-label [PRO:DNx] is_a: PR:000007152 ! eosinophil peroxidase is_a: PR:000018264 ! proteolytic cleavage product intersection_of: PR:000007152 ! eosinophil peroxidase intersection_of: RO:0002353 GO:0016485 ! output of protein processing [Term] id: PR:000019879 name: fibroblast growth factor 1 proteolytic cleavage product namespace: protein def: "A fibroblast growth factor 1 that has been processed by proteolytic cleavage." [PRO:DNx] comment: Category=modification. synonym: "FGF1/ClvPrd" EXACT PRO-short-label [PRO:DNx] is_a: PR:000007479 ! fibroblast growth factor 1 is_a: PR:000018264 ! proteolytic cleavage product intersection_of: PR:000007479 ! fibroblast growth factor 1 intersection_of: RO:0002353 GO:0016485 ! output of protein processing [Term] id: PR:000019882 name: fibroblast growth factor 2 proteolytic cleavage product namespace: protein def: "A fibroblast growth factor 2 that has been processed by proteolytic cleavage." [PRO:DNx] comment: Category=modification. synonym: "FGF2/ClvPrd" EXACT PRO-short-label [PRO:DNx] is_a: PR:000007489 ! fibroblast growth factor 2 is_a: PR:000018264 ! proteolytic cleavage product intersection_of: PR:000007489 ! fibroblast growth factor 2 intersection_of: RO:0002353 GO:0016485 ! output of protein processing [Term] id: PR:000019959 name: galanin proteolytic cleavage product namespace: protein def: "A galanin that has been processed by proteolytic cleavage." [PRO:DNx] comment: Category=modification. synonym: "GAL/ClvPrd" EXACT PRO-short-label [PRO:DNx] is_a: PR:000007806 ! galanin is_a: PR:000018264 ! proteolytic cleavage product intersection_of: PR:000007806 ! galanin intersection_of: RO:0002353 GO:0016485 ! output of protein processing [Term] id: PR:000020329 name: integrin alpha-IIb proteolytic cleavage product namespace: protein def: "An integrin alpha-IIb that has been processed by proteolytic cleavage." [PRO:DNx] comment: Category=modification. synonym: "ITGA2B/ClvPrd" EXACT PRO-short-label [PRO:DNx] is_a: PR:000009127 ! integrin alpha-IIb is_a: PR:000018264 ! proteolytic cleavage product intersection_of: PR:000009127 ! integrin alpha-IIb intersection_of: RO:0002353 GO:0016485 ! output of protein processing [Term] id: PR:000020376 name: metastasis-suppressor KiSS-1 proteolytic cleavage product namespace: protein def: "A metastasis-suppressor KiSS-1 that has been processed by proteolytic cleavage." [PRO:DNx] comment: Category=modification. synonym: "KISS1/ClvPrd" EXACT PRO-short-label [PRO:DNx] is_a: PR:000009344 ! metastasis-suppressor KiSS-1 is_a: PR:000018264 ! proteolytic cleavage product intersection_of: PR:000009344 ! metastasis-suppressor KiSS-1 intersection_of: RO:0002353 GO:0016485 ! output of protein processing [Term] id: PR:000020497 name: lactotransferrin proteolytic cleavage product namespace: protein def: "A lactotransferrin that has been processed by proteolytic cleavage." [PRO:DNx] comment: Category=modification. synonym: "LTF/ClvPrd" EXACT PRO-short-label [PRO:DNx] is_a: PR:000009978 ! lactotransferrin is_a: PR:000018264 ! proteolytic cleavage product intersection_of: PR:000009978 ! lactotransferrin intersection_of: RO:0002353 GO:0016485 ! output of protein processing [Term] id: PR:000020631 name: myeloperoxidase proteolytic cleavage product namespace: protein def: "A myeloperoxidase that has been processed by proteolytic cleavage." [PRO:DNx] comment: Category=modification. synonym: "MPO/ClvPrd" EXACT PRO-short-label [PRO:DNx] is_a: PR:000010543 ! myeloperoxidase is_a: PR:000018264 ! proteolytic cleavage product intersection_of: PR:000010543 ! myeloperoxidase intersection_of: RO:0002353 GO:0016485 ! output of protein processing [Term] id: PR:000020735 name: nuclear factor NF-kappa-B p100 subunit proteolytic cleavage product namespace: protein def: "A nuclear factor NF-kappa-B p100 subunit that has been processed by proteolytic cleavage." [PRO:DNx] comment: Category=modification. synonym: "NFKB2/ClvPrd" EXACT PRO-short-label [PRO:DNx] is_a: PR:000011178 ! nuclear factor NF-kappa-B p100 subunit is_a: PR:000018264 ! proteolytic cleavage product intersection_of: PR:000011178 ! nuclear factor NF-kappa-B p100 subunit intersection_of: RO:0002353 GO:0016485 ! output of protein processing [Term] id: PR:000020789 name: neuropeptide Y proteolytic cleavage product namespace: protein def: "A neuropeptide Y that has been processed by proteolytic cleavage." [PRO:DNx] comment: Category=modification. synonym: "NPY/ClvPrd" EXACT PRO-short-label [PRO:DNx] is_a: PR:000011387 ! neuropeptide Y is_a: PR:000018264 ! proteolytic cleavage product intersection_of: PR:000011387 ! neuropeptide Y intersection_of: RO:0002353 GO:0016485 ! output of protein processing [Term] id: PR:000020916 name: proenkephalin-B proteolytic cleavage product namespace: protein def: "A proenkephalin-B that has been processed by proteolytic cleavage." [PRO:DNx] comment: Category=modification. synonym: "PDYN/ClvPrd" EXACT PRO-short-label [PRO:DNx] is_a: PR:000012526 ! proenkephalin-B is_a: PR:000018264 ! proteolytic cleavage product intersection_of: PR:000012526 ! proenkephalin-B intersection_of: RO:0002353 GO:0016485 ! output of protein processing [Term] id: PR:000020924 name: proenkephalin-A proteolytic cleavage product namespace: protein def: "A proenkephalin-A that has been processed by proteolytic cleavage." [PRO:DNx] comment: Category=modification. synonym: "PENK/ClvPrd" EXACT PRO-short-label [PRO:DNx] is_a: PR:000012544 ! proenkephalin-A is_a: PR:000018264 ! proteolytic cleavage product intersection_of: PR:000012544 ! proenkephalin-A intersection_of: RO:0002353 GO:0016485 ! output of protein processing [Term] id: PR:000021036 name: pro-opiomelanocortin proteolytic cleavage product namespace: protein def: "A pro-opiomelanocortin that has been processed by proteolytic cleavage." [PRO:DNx] comment: Category=modification. synonym: "POMC/ClvPrd" EXACT PRO-short-label [PRO:DNx] is_a: PR:000013015 ! pro-opiomelanocortin is_a: PR:000018264 ! proteolytic cleavage product intersection_of: PR:000013015 ! pro-opiomelanocortin intersection_of: RO:0002353 GO:0016485 ! output of protein processing [Term] id: PR:000021081 name: bone marrow proteoglycan, signal peptide removed form namespace: protein def: "A bone marrow proteoglycan that has had the signal peptide removed." [PRO:DNx] comment: Category=modification. synonym: "PRG2/SigPep-" EXACT PRO-short-label [PRO:DNx] is_a: PR:000013206 ! bone marrow proteoglycan [Term] id: PR:000021082 name: bone marrow proteoglycan proteolytic cleavage product namespace: protein def: "A bone marrow proteoglycan that has been processed by proteolytic cleavage." [PRO:DNx] comment: Category=modification. synonym: "PRG2/ClvPrd" EXACT PRO-short-label [PRO:DNx] is_a: PR:000013206 ! bone marrow proteoglycan is_a: PR:000018264 ! proteolytic cleavage product intersection_of: PR:000013206 ! bone marrow proteoglycan intersection_of: RO:0002353 GO:0016485 ! output of protein processing [Term] id: PR:000021172 name: parathyroid hormone-related protein proteolytic cleavage product namespace: protein def: "A parathyroid hormone-related protein that has been processed by proteolytic cleavage." [PRO:DNx] comment: Category=modification. synonym: "PTHLH/ClvPrd" EXACT PRO-short-label [PRO:DNx] is_a: PR:000013433 ! parathyroid hormone-related protein is_a: PR:000018264 ! proteolytic cleavage product intersection_of: PR:000013433 ! parathyroid hormone-related protein intersection_of: RO:0002353 GO:0016485 ! output of protein processing [Term] id: PR:000021468 name: sonic hedgehog protein proteolytic cleavage product namespace: protein def: "A sonic hedgehog protein that has been processed by proteolytic cleavage." [PRO:DNx] comment: Category=modification. synonym: "SHH/ClvPrd" EXACT PRO-short-label [PRO:DNx] is_a: PR:000014841 ! sonic hedgehog protein is_a: PR:000018264 ! proteolytic cleavage product intersection_of: PR:000014841 ! sonic hedgehog protein intersection_of: RO:0002353 GO:0016485 ! output of protein processing [Term] id: PR:000021578 name: somatostatin proteolytic cleavage product namespace: protein def: "A somatostatin that has been processed by proteolytic cleavage." [PRO:DNx] comment: Category=modification. synonym: "SST/ClvPrd" EXACT PRO-short-label [PRO:DNx] is_a: PR:000015665 ! somatostatin is_a: PR:000018264 ! proteolytic cleavage product intersection_of: PR:000015665 ! somatostatin intersection_of: RO:0002353 GO:0016485 ! output of protein processing [Term] id: PR:000021620 name: tachykinin-3 proteolytic cleavage product namespace: protein def: "A tachykinin-3 that has been processed by proteolytic cleavage." [PRO:DNx] comment: Category=modification. synonym: "TAC3/ClvPrd" EXACT PRO-short-label [PRO:DNx] is_a: PR:000016004 ! tachykinin-3 is_a: PR:000018264 ! proteolytic cleavage product intersection_of: PR:000016004 ! tachykinin-3 intersection_of: RO:0002353 GO:0016485 ! output of protein processing [Term] id: PR:000021826 name: vasoactive intestinal polypeptides proteolytic cleavage product namespace: protein def: "A VIP peptides that has been processed by proteolytic cleavage." [PRO:DNx] comment: Category=modification. synonym: "VIP peptides proteolytic cleavage product" EXACT [PRO:DAN] synonym: "VIP/ClvPrd" EXACT PRO-short-label [PRO:DNx] is_a: PR:000017299 ! VIP peptides is_a: PR:000018264 ! proteolytic cleavage product intersection_of: PR:000017299 ! VIP peptides intersection_of: RO:0002353 GO:0016485 ! output of protein processing [Term] id: PR:000022003 name: bone marrow proteoglycan isoform 1 namespace: protein def: "A bone marrow proteoglycan that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P13727-1 or a 1:1 ortholog thereof." [PRO:CNA] comment: Category=sequence. synonym: "PRG2/iso:1" EXACT PRO-short-label [PRO:DNx] is_a: PR:000013206 ! bone marrow proteoglycan [Term] id: PR:000022006 name: eosinophil granule major basic protein namespace: protein def: "A bone marrow proteoglycan isoform 1, signal peptide removed form that has had the acidic propeptide removed." [PMID:9657764, PRO:CNA, PRO:DAN] comment: Category=modification. Requested by=CL. synonym: "PRG2/iso:1/EMBP" EXACT PRO-short-label [PRO:DAN] is_a: PR:000025466 ! bone marrow proteoglycan isoform 1, signal peptide removed form [Term] id: PR:000025402 name: T cell receptor co-receptor CD8 namespace: protein def: "A protein-containing complex that is a membrane-bound heterodimeric co-receptor for MHC class-I antigen/T-cell receptor interaction." [PMID:18275828, PMID:3264320, PRO:DAN] comment: Category=complex. Requested by=CL. synonym: "CD8alphabeta" EXACT [] synonym: "TCR co-receptor CD8" EXACT [] is_a: GO:0032991 ! protein-containing complex relationship: RO:0002180 PR:000025408 ! has component T-cell surface glycoprotein CD8 alpha chain isoform 1, signal peptide removed glycosylated form relationship: RO:0002180 PR:000025409 ! has component T-cell surface glycoprotein CD8 beta chain isoform 1, signal peptide removed glycosylated form [Term] id: PR:000025403 name: T-cell surface glycoprotein CD8 alpha chain isoform 1 namespace: protein def: "A T-cell surface glycoprotein CD8 alpha chain that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P01732-1 or a 1:1 ortholog thereof. Having a single-pass transmembrane domain, this form is membrane bound." [PRO:DAN] comment: Category=sequence. Requested by=CL. synonym: "CD8A/iso:1" EXACT PRO-short-label [PRO:DNx] synonym: "mCD8alpha" EXACT [] is_a: PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain [Term] id: PR:000025405 name: T-cell surface glycoprotein CD8 beta chain isoform 1 namespace: protein def: "A T-cell surface glycoprotein CD8 beta chain that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P10966-1 or a 1:1 ortholog thereof." [PRO:DAN] comment: Category=sequence. synonym: "CD8B/iso:1" EXACT PRO-short-label [PRO:DNx] synonym: "CD8beta isoform M-1" EXACT [PMID:1541829] is_a: PR:000001085 ! T-cell surface glycoprotein CD8 beta chain [Term] id: PR:000025406 name: T-cell surface glycoprotein CD8 alpha chain isoform 1, signal peptide removed form namespace: protein def: "A T-cell surface glycoprotein CD8 alpha chain isoform 1 that has had the signal peptide removed to yield the mature form." [PRO:DAN] comment: Category=modification. synonym: "CD8A/iso:1/SigPep-" EXACT PRO-short-label [PRO:DNx] is_a: PR:000018335 ! T-cell surface glycoprotein CD8 alpha chain, signal peptide removed form is_a: PR:000025403 ! T-cell surface glycoprotein CD8 alpha chain isoform 1 [Term] id: PR:000025407 name: T-cell surface glycoprotein CD8 beta chain isoform 1, signal peptide removed form namespace: protein def: "A T-cell surface glycoprotein CD8 beta chain isoform 1 that has had the signal peptide removed to yield the mature form." [PRO:DAN] comment: Category=modification. synonym: "CD8B/iso:1/SigPep-" EXACT PRO-short-label [PRO:DNx] is_a: PR:000018337 ! T-cell surface glycoprotein CD8 beta chain, signal peptide removed form is_a: PR:000025405 ! T-cell surface glycoprotein CD8 beta chain isoform 1 [Term] id: PR:000025408 name: T-cell surface glycoprotein CD8 alpha chain isoform 1, signal peptide removed glycosylated form namespace: protein def: "A T-cell surface glycoprotein CD8 alpha chain isoform 1, signal peptide removed form that includes at least one glycosylated residue." [PRO:DAN] comment: Category=modification. synonym: "CD8A/iso:1/SigPep-/GlycoRes+" EXACT PRO-short-label [PRO:DNx] is_a: PR:000025406 ! T-cell surface glycoprotein CD8 alpha chain isoform 1, signal peptide removed form is_a: PR:000037069 ! glycoprotein [Term] id: PR:000025409 name: T-cell surface glycoprotein CD8 beta chain isoform 1, signal peptide removed glycosylated form namespace: protein def: "A T-cell surface glycoprotein CD8 beta chain isoform 1, signal peptide removed form that includes at least one glycosylated residue." [PRO:DAN] comment: Category=modification. synonym: "CD8B/iso:1/SigPep-/GlycoRes+" EXACT PRO-short-label [PRO:DNx] is_a: PR:000025407 ! T-cell surface glycoprotein CD8 beta chain isoform 1, signal peptide removed form is_a: PR:000037069 ! glycoprotein [Term] id: PR:000025420 name: collagen alpha-1(VI) chain proteolytic cleavage product namespace: protein def: "A collagen alpha-1(VI) chain that has been processed by proteolytic cleavage." [PRO:DNx] comment: Category=modification. synonym: "COL6A1/ClvPrd" EXACT PRO-short-label [PRO:DNx] is_a: PR:000003353 ! collagen alpha-1(VI) chain is_a: PR:000018264 ! proteolytic cleavage product intersection_of: PR:000003353 ! collagen alpha-1(VI) chain intersection_of: RO:0002353 GO:0016485 ! output of protein processing [Term] id: PR:000025455 name: CD2 molecule proteolytic cleavage product namespace: protein def: "A CD2 molecule that has been processed by proteolytic cleavage." [PRO:DNx] comment: Category=modification. synonym: "CD2/ClvPrd" EXACT PRO-short-label [PRO:DNx] is_a: PR:000001083 ! CD2 molecule is_a: PR:000018264 ! proteolytic cleavage product intersection_of: PR:000001083 ! CD2 molecule intersection_of: RO:0002353 GO:0016485 ! output of protein processing [Term] id: PR:000025466 name: bone marrow proteoglycan isoform 1, signal peptide removed form namespace: protein def: "A bone marrow proteoglycan isoform 1 that has had the signal peptide removed." [PRO:DAN] comment: Category=modification. synonym: "PRG2/iso:1/SigPep-" EXACT PRO-short-label [PRO:DNx] is_a: PR:000021081 ! bone marrow proteoglycan, signal peptide removed form is_a: PR:000022003 ! bone marrow proteoglycan isoform 1 [Term] id: PR:000025670 name: killer cell lectin-like receptor subfamily B member 1 namespace: protein def: "A KLRB1-like protein that is a translation product of the human KLRB1 gene or a 1:1 ortholog thereof." [PRO:DAN] comment: Category=gene. synonym: "C-type lectin domain family 5 member B" EXACT [] synonym: "CD antigen CD161" EXACT [] synonym: "CD161" EXACT [] synonym: "CLEC5B" RELATED Gene-based [] synonym: "HNKR-P1a" EXACT [] synonym: "KLRB1" EXACT PRO-short-label [PRO:DNx] synonym: "Natural killer cell surface protein P1A" EXACT [] synonym: "NKR-P1A" BROAD [PRO:DNx] synonym: "NKRP1A" RELATED Gene-based [] is_a: PR:000001874 ! KLRB1-like protein [Term] id: PR:000025796 name: integrin alpha namespace: protein def: "A protein that is composed of a long N-terminal extracellular domain, a transmembrane domain and a short cytoplasmic C-terminal domain. The N-terminal domain contains beta-propeller repeats (interrupted by an A domain in a subset of integrins alpha), while the C-terminal domain contains a GFFxR motif." [PMID:19693543] comment: Category=family. Integrins are heterodimeric complexes of an alpha and a beta subunit. They are a structurally elaborate family of adhesion molecules that transmit signals bidirectionally across the plasma membrane by undergoing large-scale structural rearrangements. By regulating cell-cell and cell-matrix contacts, integrins participate in a wide-range of biological interactions including development, tissue repair, angiogenesis, inflammation and hemostasis. [PMID:10402956, PMID:11988479, PMID:9676575]. is_a: PR:000000001 ! protein [Term] id: PR:000025797 name: integrin alpha lacking A domain namespace: protein def: "An integrin alpha that lacks an A domain. This type of integrin is often cleaved into heavy and light chains." [PRO:DAN] comment: Category=family. synonym: "fam:ITGAsansA" EXACT PRO-short-label [PRO:DAN] xref: PIRSF:PIRSF005666 is_a: PR:000025796 ! integrin alpha [Term] id: PR:000025841 name: single domain alpha-type carbonic anhydrase namespace: protein def: "A protein that contains a single copy of the Eukaryotic-type carbonic anhydrase domain (Pfam:PF00194) with no other conserved domains." [PRO:DAN] comment: Category=family. xref: PIRSF:PIRSF001392 is_a: PR:000000001 ! protein [Term] id: PR:000027222 name: CALCA gene translation product namespace: protein def: "A protein that is a translation product of the human CALCA gene or a 1:1 ortholog thereof." [MGI:2151253, PRO:CNA] comment: Category=gene. synonym: "CALC" RELATED [] synonym: "CALCA" EXACT PRO-short-label [PRO:DNx] is_a: PR:000000001 ! protein [Term] id: PR:000027223 name: CALCA gene translation product (mouse) namespace: protein def: "A CALCA gene translation product that is encoded in the genome of mouse." [MGI:2151253, PRO:HJD] comment: Category=organism-gene. synonym: "mCALCA" EXACT PRO-short-label [PRO:DNx] is_a: PR:000027222 ! CALCA gene translation product is_a: PR:000029032 ! Mus musculus protein intersection_of: PR:000027222 ! CALCA gene translation product intersection_of: RO:0002160 NCBITaxon:10090 ! only in taxon Mus musculus [Term] id: PR:000027226 name: calcitonin gene-related peptide 1 namespace: protein def: "A CALCA gene translation product that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P06881-1 or a 1:1 ortholog thereof." [PMID:11761712, PRO:CNA, PRO:DAN] comment: Category=sequence. synonym: "alpha-type CGRP" EXACT [] synonym: "CALC1" RELATED [] synonym: "CALCA/iso:CGRP1" EXACT PRO-short-label [PRO:DAN] synonym: "calcitonin gene-related peptide I" EXACT [] synonym: "calcitonin isoform 2" EXACT [] synonym: "CGRP-I" EXACT [] is_a: PR:000027222 ! CALCA gene translation product [Term] id: PR:000027795 name: trypsin namespace: protein def: "A protein that in active form is a serine protease that cleaves peptide bonds on the carboxyl side of lysine or arginine amino acids within amino acid chains." [PRO:DAN, Wikipedia:Trypsin] comment: Category=family. synonym: "PRSS" EXACT PRO-short-label [PRO:DNx] is_a: PR:000000001 ! protein [Term] id: PR:000028527 name: casein derived peptide namespace: protein def: "A proteolytic cleavage product that is derived from any of the casein milk proteins." [PRO:DAN] comment: Category=modification. synonym: "CN (f)" EXACT PRO-short-label [PRO:DAN] is_a: PR:000018264 ! proteolytic cleavage product [Term] id: PR:000029032 name: Mus musculus protein namespace: protein def: "A protein that is encoded in the genome of Mus musculus." [PRO:DAN] synonym: "mouse protein" EXACT PRO-short-label [PRO:DAN] is_a: PR:000036194 ! eukaryotic protein intersection_of: PR:000000001 ! protein intersection_of: RO:0002160 NCBITaxon:10090 ! only in taxon Mus musculus relationship: RO:0002160 NCBITaxon:10090 ! only in taxon Mus musculus [Term] id: PR:000029067 name: Homo sapiens protein namespace: protein def: "A protein that is encoded in the genome of Homo sapiens." [PRO:DAN] synonym: "human protein" EXACT PRO-short-label [PRO:DAN] is_a: PR:000036194 ! eukaryotic protein intersection_of: PR:000000001 ! protein intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens relationship: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:000029562 name: iroquois-class homeodomain protein IRX-6 namespace: protein def: "A protein that is a translation product of the human IRX6 gene or a 1:1 ortholog thereof." [PRO:DNx] comment: Category=gene. synonym: "homeodomain protein IRXB3" EXACT [] synonym: "iroquois homeobox protein 6" EXACT [] synonym: "IRX6" EXACT PRO-short-label [PRO:DNx] synonym: "IRX7" RELATED Gene-based [] synonym: "IRXB3" RELATED Gene-based [] is_a: PR:000000001 ! protein [Term] id: PR:000029968 name: somatotropin hormone family member namespace: protein def: "A protein that is a standalone version of the Hormone_1 domain (Pfam:PF00103). In the immature form, the domain is preceded by a signal peptide." [PRO:DAN] comment: Category=family. synonym: "fam:GH1" EXACT PRO-short-label [PRO:DNx] is_a: PR:000000001 ! protein [Term] id: PR:000030026 name: CALCA gene translation product (human) namespace: protein def: "A CALCA gene translation product that is encoded in the genome of human." [PRO:DNx, UniProtKB:P06881] comment: Category=organism-gene. synonym: "alpha-type CGRP (human)" EXACT [UniProtKB:P06881] synonym: "CALC1 (human)" EXACT [UniProtKB:P06881] synonym: "calcitonin gene-related peptide I (human)" EXACT [UniProtKB:P06881] synonym: "CGRP-I (human)" EXACT [UniProtKB:P06881] synonym: "hCALCA" EXACT PRO-short-label [PRO:DNx] is_a: PR:000027222 ! CALCA gene translation product is_a: PR:000029067 ! Homo sapiens protein intersection_of: PR:000027222 ! CALCA gene translation product intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:000030035 name: G-protein coupled receptor namespace: protein def: "A protein that has G protein-coupled receptor (GPCR) activity. Each GPCR consists of a single polypeptide with an extracellular N-terminus, an intracellular C-terminus and seven hydrophobic transmembrane domains (TM1-TM7) linked by three extracellular loops (ECL1-ECL3) and three intracellular loops (ICL1-ICL3). GPCRs function as part of a heterotrimeric complex to transmit an extracellular signal across the membrane by activating an associated G-protein via the exchange of GDP for GTP on the alpha subunit." [IUPHARfam:694, PRO:DAN, Wikipedia:GPCR] comment: Category=family. Classification based on GRAFS system. [PMID:12761335] synonym: "7TM receptor" BROAD [IUPHARfam:694] synonym: "fam:GPCR" EXACT PRO-short-label [PRO:DAN] synonym: "seven-transmembrane receptor" BROAD [IUPHARfam:694] xref: IUPHARfam:694 is_a: BFO:0000004 is_a: BFO:0000040 is_a: PR:000000001 ! protein intersection_of: PR:000000001 ! protein intersection_of: RO:0002215 GO:0004930 ! capable of G protein-coupled receptor activity relationship: RO:0002215 GO:0004930 ! capable of G protein-coupled receptor activity [Term] id: PR:000032148 name: lysosome-associated membrane glycoprotein 5 namespace: protein def: "A protein that is a translation product of the human LAMP5 gene or a 1:1 ortholog thereof." [PRO:DNx] comment: Category=gene. synonym: "BAD-LAMP" EXACT [] synonym: "brain and dendritic cell-associated LAMP" EXACT [] synonym: "brain-associated LAMP-like protein" EXACT [] synonym: "C20orf103" RELATED Gene-based [] synonym: "LAMP-5" EXACT [] synonym: "LAMP5" EXACT PRO-short-label [PRO:DNx] synonym: "lysosome-associated membrane protein 5" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000032533 name: LIM/homeobox protein Lhx6 namespace: protein def: "A protein that is a translation product of the human LHX6 gene or a 1:1 ortholog thereof." [PRO:DNx] comment: Category=gene. synonym: "LHX6" EXACT PRO-short-label [PRO:DNx] synonym: "LHX6.1" RELATED Gene-based [] synonym: "LIM homeobox protein 6" EXACT [] synonym: "LIM/homeobox protein Lhx6.1" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000032708 name: piezo-type mechanosensitive ion channel component 2 namespace: protein def: "A piezo channel protein that is a translation product of the human PIEZO2 gene or a 1:1 ortholog thereof." [PRO:DNx] comment: Category=gene. synonym: "C18orf30" RELATED Gene-based [] synonym: "C18orf58" RELATED Gene-based [] synonym: "FAM38B" RELATED Gene-based [] synonym: "PIEZO2" EXACT PRO-short-label [PRO:DNx] synonym: "protein FAM38B" EXACT [] xref: IUPHARobj:2946 is_a: PR:000044682 ! piezo channel protein [Term] id: PR:000034294 name: lymphocyte antigen 75 (human) namespace: protein def: "A lymphocyte antigen 75 that is encoded in the genome of human." [PRO:DAN, UniProtKB:O60449] comment: Category=organism-gene. synonym: "C-type lectin domain family 13 member B (human)" EXACT [UniProtKB:O60449] synonym: "CD205 (human)" EXACT [UniProtKB:O60449] synonym: "CLEC13B (human)" EXACT [UniProtKB:O60449] synonym: "DEC-205 (human)" EXACT [UniProtKB:O60449] synonym: "gp200-MR6 (human)" EXACT [UniProtKB:O60449] synonym: "hLY75" EXACT PRO-short-label [PRO:DNx] synonym: "ly-75 (human)" EXACT [UniProtKB:O60449] is_a: PR:000001026 ! lymphocyte antigen 75 is_a: PR:000029067 ! Homo sapiens protein intersection_of: PR:000001026 ! lymphocyte antigen 75 intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:000036194 name: eukaryotic protein namespace: protein def: "A protein that is encoded in the genome of some Eukaryota." [PRO:DAN] synonym: "Eukaryota protein" EXACT [PRO:DAN] is_a: PR:000000001 ! protein intersection_of: PR:000000001 ! protein intersection_of: RO:0002160 NCBITaxon:2759 ! only in taxon Eukaryota relationship: RO:0002160 NCBITaxon:2759 ! only in taxon Eukaryota [Term] id: PR:000036947 name: T-cell surface glycoprotein CD1 (human) namespace: protein def: "A T-cell surface glycoprotein CD1 that is encoded in the genome of human." [PRO:DAN] comment: Category=organism-family. Requested by=IEDB. Requested by=ImmPort. synonym: "hCD1" EXACT PRO-short-label [PRO:DAN] synonym: "HLA-CD1 chain" EXACT [MRO:0000634] xref: MRO:0000634 is_a: PR:000001838 ! T-cell surface glycoprotein CD1 is_a: PR:000029067 ! Homo sapiens protein intersection_of: PR:000001838 ! T-cell surface glycoprotein CD1 intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:000037069 name: glycoprotein namespace: protein def: "A protein that includes at least one glycosylated residue." [PRO:DAN] comment: Category=modification. synonym: "glycated protein" EXACT [PRO:DAN] synonym: "glycosylated protein" EXACT [PRO:DAN] synonym: "Prot/GlycoRes+" EXACT PRO-short-label [PRO:DAN] is_a: PR:000000001 ! protein [Term] id: PR:000037797 name: paired box protein PAX namespace: protein def: "A protein that contains a copy of the 'Paired box' domain (Pfam:PF00292), a conserved amino acid motif with DNA-binding activity. Members of this class are transcription factors involved in pattern formation during embryogenesis, possibly by determining the time and place of organ initiation or morphogenesis." [PIRSF:PIRSF038195, PMID:9297966, PRO:CNA] comment: Category=family. xref: PIRSF:PIRSF038195 is_a: PR:000000001 ! protein [Term] id: PR:000037798 name: paired box protein PAX group IV namespace: protein def: "A paired box protein PAX that contains, in addition to the 'Paired box' domain (Pfam:PF00292), a C-terminal Homeobox domain (Pfam:PF00046)." [PIRSF:PIRSF500778, PMID:11750700, PMID:24951566, PRO:CNA] comment: Category=family. synonym: "paired box protein, PAX6-type" EXACT [PIRSF:PIRSF500778] xref: PIRSF:PIRSF500778 is_a: PR:000037797 ! paired box protein PAX [Term] id: PR:000040662 name: cathepsin-like protease namespace: protein def: "A protein that is a translation product of some metazoan gene that encodes a signal peptide followed by a single Cathepsin propeptide inhibitor domain (Pfam:PF08246) followed by a single Papain family cysteine protease (Pfam:PF00112) domain at the C terminus." [PRO:DAN] comment: Category=family. synonym: "cathepsin" NARROW [PRO:DAN] synonym: "fam:CTS" EXACT PRO-short-label [PRO:DNx] is_a: PR:000036194 ! eukaryotic protein relationship: RO:0002160 NCBITaxon:33208 ! only in taxon Metazoa [Term] id: PR:000044628 name: voltage-gated ion channel protein namespace: protein def: "An ion channel protein that has voltage-gated ion channel activity. A voltage-gated ion channel enables the transmembrane transfer of a solute by a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GO:0022832, PRO:XQ] comment: Category=family. synonym: "fam:vgate_ion_chan" EXACT PRO-short-label [PRO:DAN] xref: IUPHARfam:696 is_a: PR:000049983 ! ion channel protein intersection_of: PR:000049983 ! ion channel protein intersection_of: RO:0002215 GO:0005244 ! capable of voltage-gated monoatomic ion channel activity relationship: RO:0002215 GO:0005244 ! capable of voltage-gated monoatomic ion channel activity [Term] id: PR:000044633 name: dopamine receptor namespace: protein def: "A rhodopsin-like G-protein coupled receptor that is a translation product of the human DRD1 to DRD5 genes, 1:1 orthologs thereof, or pro-orthologs thereof." [PRO:XQ] comment: Category=family. Pro-orthology refers to, in this case, after-speciation gene duplication in the non-human species (aka 1:many orthology). xref: IUPHARfam:20 is_a: PR:000001094 ! rhodopsin-like G-protein coupled receptor [Term] id: PR:000044637 name: calcitonin receptor protein namespace: protein def: "A rhodopsin-like G-protein coupled receptor that is a translation product of the human CALCR or CALCRL genes, 1:1 orthologs thereof, or a semi-ortholog thereof." [PRO:XQ] comment: Category=family. xref: IUPHARfam:11 is_a: PR:000001094 ! rhodopsin-like G-protein coupled receptor [Term] id: PR:000044649 name: calcium-activated potassium channel protein namespace: protein def: "A potassium channel protein that is activated by calcium. A calcium-activated potassium channel enables the calcium concentration-regulatable energy-independent passage of potassium ions across a lipid bilayer down a concentration gradient." [GO:0015269, PRO:XQ] comment: Category=family. synonym: "fam:Ca-activ_K_chan" EXACT PRO-short-label [PRO:DAN] is_a: PR:000044651 ! calcium- and sodium-activated potassium channel protein intersection_of: PR:000044655 ! potassium channel protein intersection_of: RO:0002215 GO:0015269 ! capable of calcium-activated potassium channel activity relationship: RO:0002215 GO:0015269 ! capable of calcium-activated potassium channel activity [Term] id: PR:000044650 name: sodium-activated potassium channel protein namespace: protein def: "A potassium channel protein that is activated by sodium. A sodium-activated potassium channel enables the transmembrane transfer of potassium by a channel that opens in response to stimulus by a sodium ion or ions." [GO:0005228, PRO:XQ] comment: Category=family. synonym: "fam:Na-activ_K_chan" EXACT PRO-short-label [PRO:DAN] synonym: "intracellular sodium activated potassium channel protein" EXACT [PRO:XQ] is_a: PR:000044651 ! calcium- and sodium-activated potassium channel protein intersection_of: PR:000044655 ! potassium channel protein intersection_of: RO:0002215 GO:0005228 ! capable of intracellular sodium-activated potassium channel activity relationship: RO:0002215 GO:0005228 ! capable of intracellular sodium-activated potassium channel activity [Term] id: PR:000044651 name: calcium- and sodium-activated potassium channel protein namespace: protein def: "A potassium channel protein that is activated either by calcium or by sodium." [PRO:XQ] comment: Category=family. synonym: "fam:[Ca/Na]-activ_K_chan" EXACT PRO-short-label [PRO:DAN] xref: IUPHARfam:69 is_a: PR:000044655 ! potassium channel protein is_a: PR:000044671 ! ligand-gated ion channel protein union_of: PR:000044649 ! calcium-activated potassium channel protein union_of: PR:000044650 ! sodium-activated potassium channel protein [Term] id: PR:000044654 name: voltage-gated potassium channel protein namespace: protein def: "A potassium channel protein that has voltage-gated potassium channel activity. A voltage-gated potassium channel enables the transmembrane transfer of a potassium ion by a voltage-gated channel. A voltage-gated channel enables the transmembrane transfer of a solute by a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GO:0005249, PRO:XQ] comment: Category=family. synonym: "fam:vgate_K_chan" EXACT PRO-short-label [PRO:DAN] synonym: "voltage-dependent potassium channel protein" EXACT [PRO:XQ] synonym: "voltage-gated potassium ion channel protein" EXACT [PRO:XQ] synonym: "voltage-sensitive potassium channel protein" EXACT [PRO:XQ] xref: IUPHARfam:81 is_a: PR:000044655 ! potassium channel protein intersection_of: PR:000044655 ! potassium channel protein intersection_of: RO:0002215 GO:0005249 ! capable of voltage-gated potassium channel activity relationship: RO:0002215 GO:0005249 ! capable of voltage-gated potassium channel activity [Term] id: PR:000044655 name: potassium channel protein namespace: protein def: "A voltage-gated ion channel protein that has potassium channel activity. A potassium channel enables the facilitated diffusion of a potassium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GO:0005267, PRO:XQ] comment: Category=family. synonym: "fam:K_chan" EXACT PRO-short-label [PRO:DAN] xref: IUPHARfam:133 is_a: PR:000044628 ! voltage-gated ion channel protein intersection_of: PR:000044628 ! voltage-gated ion channel protein intersection_of: RO:0002215 GO:0005267 ! capable of potassium channel activity relationship: RO:0002215 GO:0005267 ! capable of potassium channel activity [Term] id: PR:000044657 name: transient receptor potential channel protein namespace: protein def: "A voltage-gated ion channel protein that is a translation product of the human TRPC1, TRPM1, TRPV1, TRPA1, TRPP1 or TRPML1 gene, paralogs thereof, 1:1 orthologs thereof, a semi-ortholog thereof, or pro-orthologs thereof." [PRO:XQ] comment: Category=family. synonym: "fam:TRP_chan" EXACT PRO-short-label [PRO:DAN] xref: IUPHARfam:78 is_a: PR:000044628 ! voltage-gated ion channel protein [Term] id: PR:000044658 name: voltage-gated calcium channel protein namespace: protein def: "A voltage-gated ion channel protein that has voltage-gated calcium channel activity. A voltage-gated calcium channel enables the transmembrane transfer of a calcium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GO:0005245, PRO:XQ] comment: Category=family. synonym: "depolarization-activated calcium channel protein" EXACT [PRO:XQ] synonym: "depolarization-activated voltage gated calcium channel protein" EXACT [PRO:XQ] synonym: "depolarization-activated voltage-gated calcium channel protein" EXACT [PRO:XQ] synonym: "dihydropyridine-sensitive calcium channel protein" EXACT [PRO:XQ] synonym: "fam:vgate_Ca_chan" EXACT PRO-short-label [PRO:DAN] synonym: "voltage gated calcium channel protein" EXACT [PRO:XQ] synonym: "voltage-dependent calcium channel protein" EXACT [PRO:XQ] synonym: "voltage-gated calcium ion channel protein" EXACT [PRO:XQ] synonym: "voltage-sensitive calcium channel protein" EXACT [PRO:XQ] xref: IUPHARfam:80 is_a: PR:000044628 ! voltage-gated ion channel protein intersection_of: PR:000044628 ! voltage-gated ion channel protein intersection_of: RO:0002215 GO:0005245 ! capable of voltage-gated calcium channel activity relationship: RO:0002215 GO:0005245 ! capable of voltage-gated calcium channel activity [Term] id: PR:000044660 name: voltage-gated sodium channel protein namespace: protein def: "A voltage-gated ion channel protein that has voltage-gated sodium channel activity. A voltage-gated sodium channel enables the transmembrane transfer of a sodium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GO:0005248, PRO:XQ] comment: Category=family. synonym: "fam:vgate_Na_chan" EXACT PRO-short-label [PRO:DAN] synonym: "voltage gated sodium channel protein" EXACT [PRO:XQ] synonym: "voltage-dependent sodium channel protein" EXACT [PRO:XQ] synonym: "voltage-gated sodium ion channel protein" EXACT [PRO:XQ] synonym: "voltage-sensitive sodium channel protein" EXACT [PRO:XQ] xref: IUPHARfam:82 is_a: PR:000044628 ! voltage-gated ion channel protein intersection_of: PR:000044628 ! voltage-gated ion channel protein intersection_of: RO:0002215 GO:0005248 ! capable of voltage-gated sodium channel activity relationship: RO:0002215 GO:0005248 ! capable of voltage-gated sodium channel activity [Term] id: PR:000044668 name: nicotinic acetylcholine receptor protein namespace: protein def: "A ligand-gated ion channel protein that is a translation product of the human CHRNA1-7, CHRNA9-10, CHRNB1-4, CHRNG, CHRND, or CHRNE genes, 1:1 orthologs thereof, or a semi-ortholog thereof." [PRO:XQ] comment: Category=family. xref: IUPHARfam:76 is_a: PR:000044671 ! ligand-gated ion channel protein [Term] id: PR:000044669 name: P2X receptor protein namespace: protein def: "A ligand-gated ion channel protein that is a translation product of the human P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX6, or P2RX7 genes, 1:1 orthologs thereof, or a semi-ortholog thereof." [PRO:XQ] comment: Category=family. xref: IUPHARfam:77 is_a: PR:000044671 ! ligand-gated ion channel protein [Term] id: PR:000044671 name: ligand-gated ion channel protein namespace: protein def: "An ion channel protein that has ligand-gated ion channel activity. The ligand-gated ion channel opens when a specific ligand has been bound by the channel complex or one of its constituent parts." [GO:0015276, PRO:XQ] comment: Category=family. synonym: "ionotropic receptor" NARROW [PRO:XQ] xref: IUPHARfam:697 is_a: PR:000049983 ! ion channel protein intersection_of: PR:000049983 ! ion channel protein intersection_of: RO:0002215 GO:0015276 ! capable of ligand-gated monoatomic ion channel activity relationship: RO:0002215 GO:0015276 ! capable of ligand-gated monoatomic ion channel activity [Term] id: PR:000044672 name: aquaporin protein namespace: protein def: "A channel protein that has water channel activity. A water channel enables facilitated diffusion of water (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GO:0015250, PRO:XQ] comment: Category=family. Note: Aquaporin channels operate as tetramers. [PRO:DAN, IUPHARfam:119] synonym: "water channel" EXACT [PRO:XQ] xref: IUPHARfam:119 is_a: PR:000044676 ! channel protein intersection_of: PR:000044676 ! channel protein intersection_of: RO:0002215 GO:0015250 ! capable of water channel activity relationship: RO:0002215 GO:0015250 ! capable of water channel activity [Term] id: PR:000044676 name: channel protein namespace: protein def: "A protein that has channel activity. Channel proteins enable energy-independent facilitated diffusion, mediated by passage of a solute through a transmembrane aqueous pore or channel." [GO:0015267, PRO:XQ] comment: Category=family. synonym: "channel-forming toxin protein" EXACT [PRO:XQ] synonym: "channel/pore class transporter protein" EXACT [PRO:XQ] synonym: "fam:chan" EXACT PRO-short-label [PRO:DAN] synonym: "nonselective channel protein" EXACT [PRO:XQ] synonym: "pore class transporter protein" EXACT [PRO:XQ] synonym: "pore protein" EXACT [PRO:XQ] is_a: BFO:0000004 is_a: BFO:0000040 is_a: CHEBI:36080 is_a: PR:000000001 ! protein intersection_of: PR:000000001 ! protein intersection_of: RO:0002215 GO:0015267 ! capable of channel activity relationship: RO:0002215 GO:0015267 ! capable of channel activity [Term] id: PR:000044682 name: piezo channel protein namespace: protein def: "An ion channel protein that is a translation product of the human PIEZO1 or PIEZO2 genes, 1:1 orthologs thereof, or a semi-ortholog thereof." [PRO:XQ] comment: Category=family. Note: Piezo channels are mechanosensitive ion channels that operate as homotrimers. [PRO:DAN, PMID:29376828] synonym: "fam:piezo_chan" EXACT PRO-short-label [PRO:DAN] xref: IUPHARfam:967 is_a: PR:000049983 ! ion channel protein [Term] id: PR:000044780 name: leukocyte immunoglobulin-like receptor subfamily member namespace: protein comment: Category=family. Requested by=HPO/MPO. synonym: "fam:LILR" EXACT PRO-short-label [PRO:DAN] is_a: PR:000000001 ! protein [Term] id: PR:000045358 name: insulin family protein namespace: protein def: "A protein that is a translation product of a gene that encodes a standalone Insulin (Pfam:PF00049) domain preceded by a signal peptide." [PRO:DAN] comment: Category=family. synonym: "fam:INS" EXACT PRO-short-label [PRO:DAN] is_a: PR:000000001 ! protein [Term] id: PR:000049928 name: amino-acid residue related to L-tyrosine namespace: protein def: "An amino-acid residue that is either a modified or unmodified L-tyrosine residue." [PRO:DAN] comment: Category=external. is_a: CHEBI:33708 union_of: CHEBI:46858 union_of: MOD:00919 [Term] id: PR:000049983 name: ion channel protein namespace: protein def: "A channel protein that has ion channel activity. An ion channel enables the facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [IUPHARfam:689, PRO:XQ] comment: Category=family. synonym: "fam:ion_chan" EXACT PRO-short-label [PRO:DAN] xref: IUPHARfam:689 is_a: PR:000044676 ! channel protein intersection_of: PR:000044676 ! channel protein intersection_of: RO:0002215 GO:0005216 ! capable of monoatomic ion channel activity relationship: RO:0002215 GO:0005216 ! capable of monoatomic ion channel activity [Term] id: PR:000050025 name: angiotensinogenase namespace: protein def: "A protein that is a translation product of the mouse Ren1 or Ren2 genes, 1:1 orthologs thereof, or a semi-ortholog thereof." [PRO:DAN] comment: Category=family. synonym: "fam:angiotensinogenase" EXACT PRO-short-label [PRO:DAN] is_a: PR:000000001 ! protein [Term] id: PR:000050032 name: immunoglobulin complex (human) namespace: protein def: "An immunoglobulin complex whose components are encoded in the genome of human." [PRO:DAN] comment: Category=organism-complex. synonym: "hIg" EXACT PRO-short-label [PRO:DAN] is_a: GO:0019814 ! immunoglobulin complex intersection_of: GO:0019814 ! immunoglobulin complex intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens relationship: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:000050216 name: receptor-type tyrosine-protein phosphatase C isoform CD45R namespace: protein def: "A receptor-type tyrosine-protein phosphatase C that is a translation product of a transcript that minimally includes the region encoded by the variable exon 4(A)." [GOC:add, PRO:ADD, PRO:DAN] comment: Category=seqgroup. Requested by=CL. synonym: "CD45R" EXACT [] synonym: "PTPRC/iso:CD45R" EXACT PRO-short-label [PRO:DNx] is_a: PR:000001006 ! receptor-type tyrosine-protein phosphatase C [Term] id: PR:000050370 name: H-2 class II histocompatibility antigen, E alpha chain (mouse) namespace: protein def: "An MHC class II histocompatibility antigen alpha chain DRA that is encoded in the genome of mouse." [PRO:DAN] comment: Category=organism-gene. synonym: "mH2-Ea" EXACT PRO-short-label [PRO:DAN] is_a: PR:000002015 ! MHC class II histocompatibility antigen alpha chain DRA is_a: PR:000029032 ! Mus musculus protein intersection_of: PR:000002015 ! MHC class II histocompatibility antigen alpha chain DRA intersection_of: RO:0002160 NCBITaxon:10090 ! only in taxon Mus musculus [Term] id: PR:000050467 name: hemoglobin subunit namespace: protein def: "A protein that is a translation product of the human HBA1, HBA2, HBB, HBD, HBE1, HBG1, HBG2, HBM, HBQ1, or HBZ genes, 1:1 orthologs thereof, or semi-orthologs thereof." [PRO:DAN] comment: Category=family. synonym: "fam:Hb" EXACT PRO-short-label [PRO:DAN] is_a: PR:000000001 ! protein [Term] id: PR:000050522 name: medium-wave-sensitive opsin (human) namespace: protein def: "A medium-wave-sensitive opsin that is encoded in the genome of human." [PRO:DAN] comment: Category=organism-family. Note: The OPN1MW, OPN1MW2, and OPN1MW3 genes encode identical proteins. synonym: "hOPN1MW" EXACT PRO-short-label [PRO:DAN] synonym: "OPN1MW" NARROW Gene-based [UniProtKB:P04001] synonym: "OPN1MW2" NARROW Gene-based [UniProtKB:P0DN77] synonym: "OPN1MW3" NARROW Gene-based [UniProtKB:P0DN78] is_a: PR:000001224 ! medium-wave-sensitive opsin is_a: PR:000029067 ! Homo sapiens protein intersection_of: PR:000001224 ! medium-wave-sensitive opsin intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens union_of: PR:P04001 ! medium-wave-sensitive opsin 1 (human) union_of: PR:P0DN77 ! medium-wave-sensitive opsin 2 (human) union_of: PR:P0DN78 ! medium-wave-sensitive opsin 3 (human) [Term] id: PR:000064867 name: protein-containing molecular entity namespace: protein def: "A molecular entity that minimally consists of a protein." [PRO:DAN] comment: Note: This includes single proteins and derivatives thereof (PR:000000001), protein-containing complexes (GO:0032991), and protein aggregates (PR:000050565). synonym: "protein" NARROW [PRO:DAN] synonym: "protein aggregate" NARROW [PRO:DAN] synonym: "protein complex" NARROW [PRO:DAN] synonym: "protein-containing complex" NARROW [PRO:DAN] is_a: CHEBI:23367 intersection_of: CHEBI:23367 intersection_of: BFO:0000051 PR:000000001 ! has part protein relationship: BFO:0000051 PR:000000001 ! has part protein [Term] id: PR:A0A0B4J238 name: T cell receptor alpha variable 1-2 (human) namespace: protein def: "A protein that is a translation product of the TRAV1-2 gene in human." [PRO:DNx, UniProtKB:A0A0B4J238] comment: Category=organism-gene. synonym: "hTRAV1-2" EXACT PRO-short-label [PRO:DNx] synonym: "TRAV1-2" RELATED Gene-based [UniProtKB:A0A0B4J238] xref: UniProtKB:A0A0B4J238 is_a: PR:000029067 ! Homo sapiens protein [Term] id: PR:A2VEC9 name: SCO-spondin (human) namespace: protein def: "A SCO-spondin that is encoded in the genome of human." [PRO:DNx, UniProtKB:A2VEC9] comment: Category=organism-gene. synonym: "hSSPO" EXACT PRO-short-label [PRO:DNx] synonym: "KIAA2036" RELATED Gene-based [UniProtKB:A2VEC9] synonym: "SCO-spondin pseudogene (human)" EXACT [UniProtKB:A2VEC9] synonym: "SSPO" RELATED Gene-based [UniProtKB:A2VEC9] synonym: "SSPOP" RELATED Gene-based [UniProtKB:A2VEC9] xref: UniProtKB:A2VEC9 is_a: PR:000015658 ! SCO-spondin is_a: PR:000029067 ! Homo sapiens protein intersection_of: PR:000015658 ! SCO-spondin intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:O00253 name: agouti-related protein (human) namespace: protein def: "An agouti-related protein that is encoded in the genome of human." [PRO:DNx, UniProtKB:O00253] comment: Category=organism-gene. synonym: "AGRP" RELATED Gene-based [UniProtKB:O00253] synonym: "AGRT" RELATED Gene-based [UniProtKB:O00253] synonym: "ART" RELATED Gene-based [UniProtKB:O00253] synonym: "hAGRP" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:O00253 is_a: PR:000003846 ! agouti-related protein is_a: PR:000029067 ! Homo sapiens protein intersection_of: PR:000003846 ! agouti-related protein intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:O09100 name: endothelial transcription factor GATA-2 (mouse) namespace: protein def: "An endothelial transcription factor GATA-2 that is encoded in the genome of mouse." [OMA:O09100, PRO:DNx] comment: Category=organism-gene. synonym: "GATA-binding protein 2 (mouse)" EXACT [UniProtKB:O09100] synonym: "Gata2" RELATED Gene-based [UniProtKB:O09100] synonym: "mGATA2" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:O09100 is_a: PR:000007858 ! endothelial transcription factor GATA-2 is_a: PR:000029032 ! Mus musculus protein intersection_of: PR:000007858 ! endothelial transcription factor GATA-2 intersection_of: RO:0002160 NCBITaxon:10090 ! only in taxon Mus musculus [Term] id: PR:O14638 name: ectonucleotide pyrophosphatase/phosphodiesterase family member 3 (human) namespace: protein def: "An ectonucleotide pyrophosphatase/phosphodiesterase family member 3 that is encoded in the genome of human." [PRO:WCB, UniProtKB:O14638] comment: Category=organism-gene. synonym: "alkaline phosphodiesterase I (human)" RELATED [UniProtKB:O14638] synonym: "CD203c (human)" EXACT [UniProtKB:O14638] synonym: "dinucleoside polyphosphatase (human)" EXACT [UniProtKB:O14638] synonym: "E-NPP 3 (human)" EXACT [UniProtKB:O14638] synonym: "ENPP3" RELATED Gene-based [UniProtKB:O14638] synonym: "hENPP3" EXACT PRO-short-label [PRO:DNx] synonym: "NPP3 (human)" EXACT [UniProtKB:O14638] synonym: "NPPase (human)" RELATED [UniProtKB:O14638] synonym: "nucleotide diphosphatase (human)" RELATED [UniProtKB:O14638] synonym: "nucleotide pyrophosphatase (human)" RELATED [UniProtKB:O14638] synonym: "PD-Ibeta (human)" EXACT [UniProtKB:O14638] synonym: "PDNP3" RELATED Gene-based [UniProtKB:O14638] synonym: "phosphodiesterase I beta (human)" EXACT [UniProtKB:O14638] synonym: "phosphodiesterase I/nucleotide pyrophosphatase 3 (human)" EXACT [UniProtKB:O14638] xref: Reactome:R-HSA-8939012 "PR:O14638 located_in GO:0005886" xref: UniProtKB:O14638 is_a: PR:000001344 ! ectonucleotide pyrophosphatase/phosphodiesterase family member 3 is_a: PR:000029067 ! Homo sapiens protein intersection_of: PR:000001344 ! ectonucleotide pyrophosphatase/phosphodiesterase family member 3 intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:O14770 name: homeobox protein Meis2 (human) namespace: protein def: "A homeobox protein Meis2 that is encoded in the genome of human." [PRO:DNx, UniProtKB:O14770] comment: Category=organism-gene. synonym: "hMEIS2" EXACT PRO-short-label [PRO:DNx] synonym: "Meis1-related protein 1 (human)" EXACT [UniProtKB:O14770] synonym: "MEIS2" RELATED Gene-based [UniProtKB:O14770] synonym: "MRG1" RELATED Gene-based [UniProtKB:O14770] xref: UniProtKB:O14770 is_a: PR:000010317 ! homeobox protein Meis2 is_a: PR:000029067 ! Homo sapiens protein intersection_of: PR:000010317 ! homeobox protein Meis2 intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:O15353 name: forkhead box protein N1 (human) namespace: protein def: "A forkhead box protein N1 that is encoded in the genome of human." [PRO:DNx, UniProtKB:O15353] comment: Category=organism-gene. synonym: "FOXN1" RELATED Gene-based [UniProtKB:O15353] synonym: "hFOXN1" EXACT PRO-short-label [PRO:DNx] synonym: "RONU" RELATED Gene-based [UniProtKB:O15353] synonym: "WHN" RELATED Gene-based [UniProtKB:O15353] synonym: "winged-helix transcription factor nude (human)" EXACT [UniProtKB:O15353] xref: UniProtKB:O15353 is_a: PR:000007636 ! forkhead box protein N1 is_a: PR:000029067 ! Homo sapiens protein intersection_of: PR:000007636 ! forkhead box protein N1 intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:O15389 name: sialic acid-binding Ig-like lectin 5 (human) namespace: protein def: "A sialic acid-binding Ig-like lectin 5 that is encoded in the genome of human." [PRO:WCB, UniProtKB:O15389] comment: Category=organism-gene. synonym: "CD170 (human)" EXACT [UniProtKB:O15389] synonym: "CD33 antigen-like 2 (human)" EXACT [UniProtKB:O15389] synonym: "CD33L2" RELATED Gene-based [UniProtKB:O15389] synonym: "hSIGLEC5" EXACT PRO-short-label [PRO:DNx] synonym: "OB-binding protein 2 (human)" EXACT [UniProtKB:O15389] synonym: "OB-BP2 (human)" EXACT [UniProtKB:O15389] synonym: "OBBP2" RELATED Gene-based [UniProtKB:O15389] synonym: "obesity-binding protein 2 (human)" EXACT [UniProtKB:O15389] synonym: "siglec-5 (human)" EXACT [UniProtKB:O15389] synonym: "SIGLEC5" RELATED Gene-based [UniProtKB:O15389] xref: UniProtKB:O15389 is_a: PR:000001927 ! sialic acid-binding Ig-like lectin 5 is_a: PR:000029067 ! Homo sapiens protein intersection_of: PR:000001927 ! sialic acid-binding Ig-like lectin 5 intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:O35205 name: granzyme K (mouse) namespace: protein def: "A granzyme K that is encoded in the genome of mouse." [OMA:O35205, PRO:DNx] comment: Category=organism-gene. synonym: "Gzmk" RELATED Gene-based [UniProtKB:O35205] synonym: "mGZMK" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:O35205 is_a: PR:000003472 ! granzyme K is_a: PR:000029032 ! Mus musculus protein intersection_of: PR:000003472 ! granzyme K intersection_of: RO:0002160 NCBITaxon:10090 ! only in taxon Mus musculus [Term] id: PR:O35304 name: vesicular acetylcholine transporter (mouse) namespace: protein def: "A vesicular acetylcholine transporter that is encoded in the genome of mouse." [OMA:O35304, PRO:DNx] comment: Category=organism-gene. synonym: "mSLC18A3" EXACT PRO-short-label [PRO:DNx] synonym: "Slc18a3" RELATED Gene-based [UniProtKB:O35304] synonym: "solute carrier family 18 member 3 (mouse)" EXACT [UniProtKB:O35304] synonym: "Vacht" RELATED Gene-based [UniProtKB:O35304] synonym: "VAChT (mouse)" EXACT [UniProtKB:O35304] xref: UniProtKB:O35304 is_a: PR:000014968 ! vesicular acetylcholine transporter is_a: PR:000029032 ! Mus musculus protein intersection_of: PR:000014968 ! vesicular acetylcholine transporter intersection_of: RO:0002160 NCBITaxon:10090 ! only in taxon Mus musculus [Term] id: PR:O35305 name: tumor necrosis factor receptor superfamily member 11A (mouse) namespace: protein def: "A tumor necrosis factor receptor superfamily member 11A that is encoded in the genome of mouse." [OMA:O35305, PRO:DNx] comment: Category=organism-gene. synonym: "CD265 (mouse)" EXACT [UniProtKB:O35305] synonym: "mTNFRSF11A" EXACT PRO-short-label [PRO:DNx] synonym: "ODFR (mouse)" EXACT [UniProtKB:O35305] synonym: "osteoclast differentiation factor receptor (mouse)" EXACT [UniProtKB:O35305] synonym: "Rank" RELATED Gene-based [UniProtKB:O35305] synonym: "receptor activator of NF-KB (mouse)" EXACT [UniProtKB:O35305] synonym: "Tnfrsf11a" RELATED Gene-based [UniProtKB:O35305] xref: UniProtKB:O35305 is_a: PR:000001954 ! tumor necrosis factor receptor superfamily member 11A is_a: PR:000029032 ! Mus musculus protein intersection_of: PR:000001954 ! tumor necrosis factor receptor superfamily member 11A intersection_of: RO:0002160 NCBITaxon:10090 ! only in taxon Mus musculus [Term] id: PR:O35417 name: proenkephalin-B (mouse) namespace: protein def: "A proenkephalin-B that is encoded in the genome of mouse." [OMA:O35417, PRO:DNx] comment: Category=organism-gene. synonym: "beta-neoendorphin-dynorphin (mouse)" EXACT [UniProtKB:O35417] synonym: "mPDYN" EXACT PRO-short-label [PRO:DNx] synonym: "Pdyn" RELATED Gene-based [UniProtKB:O35417] synonym: "preprodynorphin (mouse)" EXACT [UniProtKB:O35417] xref: UniProtKB:O35417 is_a: PR:000012526 ! proenkephalin-B is_a: PR:000029032 ! Mus musculus protein intersection_of: PR:000012526 ! proenkephalin-B intersection_of: RO:0002160 NCBITaxon:10090 ! only in taxon Mus musculus [Term] id: PR:O35930 name: platelet glycoprotein Ib alpha chain (mouse) namespace: protein def: "A platelet glycoprotein Ib alpha chain that is encoded in the genome of mouse." [OMA:O35930, PRO:DNx] comment: Category=organism-gene. synonym: "CD42b (mouse)" EXACT [UniProtKB:O35930] synonym: "glycoprotein Ibalpha (mouse)" EXACT [UniProtKB:O35930] synonym: "GP-Ib alpha (mouse)" EXACT [UniProtKB:O35930] synonym: "Gp1ba" RELATED Gene-based [UniProtKB:O35930] synonym: "GPIb-alpha (mouse)" EXACT [UniProtKB:O35930] synonym: "GPIbA (mouse)" EXACT [UniProtKB:O35930] synonym: "mGP1BA" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:O35930 is_a: PR:000001907 ! platelet glycoprotein Ib alpha chain is_a: PR:000029032 ! Mus musculus protein intersection_of: PR:000001907 ! platelet glycoprotein Ib alpha chain intersection_of: RO:0002160 NCBITaxon:10090 ! only in taxon Mus musculus [Term] id: PR:O43490 name: prominin-1 (human) namespace: protein def: "A prominin-1 that is encoded in the genome of human." [PRO:CNA, UniProtKB:O43490] comment: Category=organism-gene. synonym: "antigen AC133 (human)" EXACT [UniProtKB:O43490] synonym: "CD133 (human)" EXACT [UniProtKB:O43490] synonym: "hPROM1" EXACT PRO-short-label [PRO:DNx] synonym: "MSTP061" RELATED Gene-based [UniProtKB:O43490] synonym: "PROM1" RELATED Gene-based [UniProtKB:O43490] synonym: "prominin-like protein 1 (human)" EXACT [UniProtKB:O43490] synonym: "PROML1" RELATED Gene-based [UniProtKB:O43490] xref: UniProtKB:O43490 is_a: PR:000001786 ! prominin-1 is_a: PR:000029067 ! Homo sapiens protein intersection_of: PR:000001786 ! prominin-1 intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:O43699 name: sialic acid-binding Ig-like lectin 6 (human) namespace: protein def: "A sialic acid-binding Ig-like lectin 6 that is encoded in the genome of human." [PRO:WCB, UniProtKB:O43699] comment: Category=organism-gene. synonym: "CD327 (human)" EXACT [UniProtKB:O43699] synonym: "CD33 antigen-like 1 (human)" EXACT [UniProtKB:O43699] synonym: "CD33L" RELATED Gene-based [UniProtKB:O43699] synonym: "CD33L1" RELATED Gene-based [UniProtKB:O43699] synonym: "CDw327 (human)" EXACT [UniProtKB:O43699] synonym: "hSIGLEC6" EXACT PRO-short-label [PRO:DNx] synonym: "OB-BP1 (human)" EXACT [UniProtKB:O43699] synonym: "OBBP1" RELATED Gene-based [UniProtKB:O43699] synonym: "obesity-binding protein 1 (human)" EXACT [UniProtKB:O43699] synonym: "siglec-6 (human)" EXACT [UniProtKB:O43699] synonym: "SIGLEC6" RELATED Gene-based [UniProtKB:O43699] xref: UniProtKB:O43699 is_a: PR:000001928 ! sialic acid-binding Ig-like lectin 6 is_a: PR:000029067 ! Homo sapiens protein intersection_of: PR:000001928 ! sialic acid-binding Ig-like lectin 6 intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:O54689 name: C-C chemokine receptor type 6 (mouse) namespace: protein def: "A C-C chemokine receptor type 6 that is encoded in the genome of mouse." [OMA:O54689, PRO:DNx] comment: Category=organism-gene. synonym: "C-C CKR-6 (mouse)" EXACT [UniProtKB:O54689] synonym: "CC-CKR-6 (mouse)" EXACT [UniProtKB:O54689] synonym: "CCR-6 (mouse)" EXACT [UniProtKB:O54689] synonym: "Ccr6" RELATED Gene-based [UniProtKB:O54689] synonym: "CD196 (mouse)" EXACT [UniProtKB:O54689] synonym: "Cmkbr6" RELATED Gene-based [UniProtKB:O54689] synonym: "KY411 (mouse)" EXACT [UniProtKB:O54689] synonym: "mCCR6" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:O54689 is_a: PR:000001202 ! C-C chemokine receptor type 6 is_a: PR:000029032 ! Mus musculus protein intersection_of: PR:000001202 ! C-C chemokine receptor type 6 intersection_of: RO:0002160 NCBITaxon:10090 ! only in taxon Mus musculus [Term] id: PR:O54707 name: natural killer cells antigen CD94 (mouse) namespace: protein def: "A killer cell lectin-like receptor subfamily D member 1 that is encoded in the genome of mouse." [OMA:O54707, PRO:DNx] comment: Category=organism-gene. synonym: "Cd94" RELATED Gene-based [UniProtKB:O54707] synonym: "CD94 (mouse)" EXACT [UniProtKB:O54707] synonym: "killer cell lectin-like receptor subfamily D member 1 (mouse)" EXACT [UniProtKB:O54707] synonym: "Klrd1" RELATED Gene-based [UniProtKB:O54707] synonym: "mKLRD1" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:O54707 is_a: PR:000001402 ! killer cell lectin-like receptor subfamily D member 1 is_a: PR:000029032 ! Mus musculus protein intersection_of: PR:000001402 ! killer cell lectin-like receptor subfamily D member 1 intersection_of: RO:0002160 NCBITaxon:10090 ! only in taxon Mus musculus [Term] id: PR:O54839 name: eomesodermin homolog (mouse) namespace: protein def: "An eomesodermin that is encoded in the genome of mouse." [OMA:O54839, PRO:DNx] comment: Category=organism-gene. synonym: "Eomes" RELATED Gene-based [UniProtKB:O54839] synonym: "mEOMES" EXACT PRO-short-label [PRO:DNx] synonym: "T-box brain protein 2 (mouse)" EXACT [UniProtKB:O54839] synonym: "T-brain-2 (mouse)" EXACT [UniProtKB:O54839] synonym: "TBR-2 (mouse)" EXACT [UniProtKB:O54839] synonym: "Tbr2" RELATED Gene-based [UniProtKB:O54839] xref: UniProtKB:O54839 is_a: PR:000003463 ! eomesodermin is_a: PR:000029032 ! Mus musculus protein intersection_of: PR:000003463 ! eomesodermin intersection_of: RO:0002160 NCBITaxon:10090 ! only in taxon Mus musculus [Term] id: PR:O54990 name: prominin-1 (mouse) namespace: protein def: "A prominin-1 that is encoded in the genome of mouse." [OMA:O54990, PRO:DNx] comment: Category=organism-gene. synonym: "antigen AC133 homolog (mouse)" EXACT [UniProtKB:O54990] synonym: "CD133 (mouse)" EXACT [UniProtKB:O54990] synonym: "mPROM1" EXACT PRO-short-label [PRO:DNx] synonym: "Prom" RELATED Gene-based [UniProtKB:O54990] synonym: "Prom1" RELATED Gene-based [UniProtKB:O54990] synonym: "prominin-like protein 1 (mouse)" EXACT [UniProtKB:O54990] synonym: "Proml1" RELATED Gene-based [UniProtKB:O54990] xref: UniProtKB:O54990 is_a: PR:000001786 ! prominin-1 is_a: PR:000029032 ! Mus musculus protein intersection_of: PR:000001786 ! prominin-1 intersection_of: RO:0002160 NCBITaxon:10090 ! only in taxon Mus musculus [Term] id: PR:O76036 name: natural cytotoxicity triggering receptor 1 (human) namespace: protein def: "A natural cytotoxicity triggering receptor 1 that is encoded in the genome of human." [PRO:WCB, UniProtKB:O76036] comment: Category=organism-gene. synonym: "CD335 (human)" EXACT [UniProtKB:O76036] synonym: "hNCR1" EXACT PRO-short-label [PRO:DNx] synonym: "hNKp46" EXACT [UniProtKB:O76036] synonym: "LY94" RELATED Gene-based [UniProtKB:O76036] synonym: "lymphocyte antigen 94 homolog (human)" EXACT [UniProtKB:O76036] synonym: "natural killer cell p46-related protein (human)" EXACT [UniProtKB:O76036] synonym: "NCR1" RELATED Gene-based [UniProtKB:O76036] synonym: "NK cell-activating receptor (human)" BROAD [UniProtKB:O76036] synonym: "NK-p46 (human)" EXACT [UniProtKB:O76036] synonym: "NKp46 (human)" EXACT [UniProtKB:O76036] xref: UniProtKB:O76036 is_a: PR:000001893 ! natural cytotoxicity triggering receptor 1 is_a: PR:000029067 ! Homo sapiens protein intersection_of: PR:000001893 ! natural cytotoxicity triggering receptor 1 intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:O76070 name: gamma-synuclein (human) namespace: protein def: "A gamma-synuclein that is encoded in the genome of human." [PRO:DNx, UniProtKB:O76070] comment: Category=organism-gene. synonym: "BCSG1" RELATED Gene-based [UniProtKB:O76070] synonym: "breast cancer-specific gene 1 protein (human)" EXACT [UniProtKB:O76070] synonym: "hSNCG" EXACT PRO-short-label [PRO:DNx] synonym: "PERSYN" RELATED Gene-based [UniProtKB:O76070] synonym: "PRSN" RELATED Gene-based [UniProtKB:O76070] synonym: "SNCG" RELATED Gene-based [UniProtKB:O76070] synonym: "SR (human)" EXACT [UniProtKB:O76070] synonym: "synoretin (human)" EXACT [UniProtKB:O76070] xref: UniProtKB:O76070 is_a: PR:000015325 ! gamma-synuclein is_a: PR:000029067 ! Homo sapiens protein intersection_of: PR:000015325 ! gamma-synuclein intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:O88324 name: CD83 antigen (mouse) namespace: protein def: "A CD83 molecule that is encoded in the genome of mouse." [OMA:O88324, PRO:DNx] comment: Category=organism-gene. synonym: "Cd83" RELATED Gene-based [UniProtKB:O88324] synonym: "CD83 (mouse)" EXACT [UniProtKB:O88324] synonym: "mCD83" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:O88324 is_a: PR:000001310 ! CD83 molecule is_a: PR:000029032 ! Mus musculus protein intersection_of: PR:000001310 ! CD83 molecule intersection_of: RO:0002160 NCBITaxon:10090 ! only in taxon Mus musculus [Term] id: PR:O88410 name: C-X-C chemokine receptor type 3 (mouse) namespace: protein def: "A C-X-C chemokine receptor type 3 that is encoded in the genome of mouse." [OMA:O88410, PRO:DNx] comment: Category=organism-gene. synonym: "CD183 (mouse)" EXACT [UniProtKB:O88410] synonym: "Cmkar3" RELATED Gene-based [UniProtKB:O88410] synonym: "CXC-R3 (mouse)" EXACT [UniProtKB:O88410] synonym: "CXCR-3 (mouse)" EXACT [UniProtKB:O88410] synonym: "Cxcr3" RELATED Gene-based [UniProtKB:O88410] synonym: "interferon-inducible protein 10 receptor (mouse)" EXACT [UniProtKB:O88410] synonym: "IP-10 receptor (mouse)" EXACT [UniProtKB:O88410] synonym: "mCXCR3" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:O88410 is_a: PR:000001207 ! C-X-C chemokine receptor type 3 is_a: PR:000029032 ! Mus musculus protein intersection_of: PR:000001207 ! C-X-C chemokine receptor type 3 intersection_of: RO:0002160 NCBITaxon:10090 ! only in taxon Mus musculus [Term] id: PR:O88713 name: killer cell lectin-like receptor subfamily G member 1 (mouse) namespace: protein def: "A killer cell lectin-like receptor subfamily G member 1 that is encoded in the genome of mouse." [OMA:O88713, PRO:DNx] comment: Category=organism-gene. synonym: "Klrg1" RELATED Gene-based [UniProtKB:O88713] synonym: "Mafa" RELATED Gene-based [UniProtKB:O88713] synonym: "mast cell function-associated antigen 2F1 (mouse)" EXACT [UniProtKB:O88713] synonym: "mKLRG1" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:O88713 is_a: PR:000009426 ! killer cell lectin-like receptor subfamily G member 1 is_a: PR:000029032 ! Mus musculus protein intersection_of: PR:000009426 ! killer cell lectin-like receptor subfamily G member 1 intersection_of: RO:0002160 NCBITaxon:10090 ! only in taxon Mus musculus [Term] id: PR:O88875 name: CD160 antigen (mouse) namespace: protein def: "A CD160 molecule that is encoded in the genome of mouse." [OMA:O88875, PRO:DNx] comment: Category=organism-gene. synonym: "By55" RELATED Gene-based [UniProtKB:O88875] synonym: "Cd160" RELATED Gene-based [UniProtKB:O88875] synonym: "CD160 (mouse)" EXACT [UniProtKB:O88875] synonym: "mCD160" EXACT PRO-short-label [PRO:DNx] synonym: "natural killer cell receptor BY55 (mouse)" EXACT [UniProtKB:O88875] xref: UniProtKB:O88875 is_a: PR:000001082 ! CD160 molecule is_a: PR:000029032 ! Mus musculus protein intersection_of: PR:000001082 ! CD160 molecule intersection_of: RO:0002160 NCBITaxon:10090 ! only in taxon Mus musculus [Term] id: PR:O89103 name: complement component C1q receptor (mouse) namespace: protein def: "A complement component C1q receptor that is encoded in the genome of mouse." [OMA:O89103, PRO:DNx] comment: Category=organism-gene. synonym: "Aa4" RELATED Gene-based [UniProtKB:O89103] synonym: "C1q/MBL/SPA receptor (mouse)" EXACT [UniProtKB:O89103] synonym: "C1qR(p) (mouse)" EXACT [UniProtKB:O89103] synonym: "C1qr1" RELATED Gene-based [UniProtKB:O89103] synonym: "C1qrp" RELATED Gene-based [UniProtKB:O89103] synonym: "C1qRp (mouse)" EXACT [UniProtKB:O89103] synonym: "Cd93" RELATED Gene-based [UniProtKB:O89103] synonym: "CD93 (mouse)" EXACT [UniProtKB:O89103] synonym: "cell surface antigen AA4 (mouse)" EXACT [UniProtKB:O89103] synonym: "complement component 1 q subcomponent receptor 1 (mouse)" EXACT [UniProtKB:O89103] synonym: "Ly-68 (mouse)" EXACT [UniProtKB:O89103] synonym: "Ly68" RELATED Gene-based [UniProtKB:O89103] synonym: "lymphocyte antigen 68 (mouse)" EXACT [UniProtKB:O89103] synonym: "mCD93" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:O89103 is_a: PR:000002037 ! complement component C1q receptor is_a: PR:000029032 ! Mus musculus protein intersection_of: PR:000002037 ! complement component C1q receptor intersection_of: RO:0002160 NCBITaxon:10090 ! only in taxon Mus musculus [Term] id: PR:O95343 name: homeobox protein SIX3 (human) namespace: protein def: "A homeobox protein SIX3 that is encoded in the genome of human." [PRO:DNx, UniProtKB:O95343] comment: Category=organism-gene. synonym: "hSIX3" EXACT PRO-short-label [PRO:DNx] synonym: "sine oculis homeobox homolog 3 (human)" EXACT [UniProtKB:O95343] synonym: "SIX3" RELATED Gene-based [UniProtKB:O95343] xref: UniProtKB:O95343 is_a: PR:000014898 ! homeobox protein SIX3 is_a: PR:000029067 ! Homo sapiens protein intersection_of: PR:000014898 ! homeobox protein SIX3 intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:O95817 name: BAG family molecular chaperone regulator 3 (human) namespace: protein def: "A BAG family molecular chaperone regulator 3 that is encoded in the genome of human." [PRO:DNx, UniProtKB:O95817] comment: Category=organism-gene. synonym: "BAG-3 (human)" EXACT [UniProtKB:O95817] synonym: "BAG3" RELATED Gene-based [UniProtKB:O95817] synonym: "Bcl-2-associated athanogene 3 (human)" EXACT [UniProtKB:O95817] synonym: "Bcl-2-binding protein Bis (human)" EXACT [UniProtKB:O95817] synonym: "BIS" RELATED Gene-based [UniProtKB:O95817] synonym: "docking protein CAIR-1 (human)" EXACT [UniProtKB:O95817] synonym: "hBAG3" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:O95817 is_a: PR:000004621 ! BAG family molecular chaperone regulator 3 is_a: PR:000029067 ! Homo sapiens protein intersection_of: PR:000004621 ! BAG family molecular chaperone regulator 3 intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:O95936 name: eomesodermin homolog (human) namespace: protein def: "An eomesodermin that is encoded in the genome of human." [PRO:CNA, UniProtKB:O95936] comment: Category=organism-gene. synonym: "EOMES" RELATED Gene-based [UniProtKB:O95936] synonym: "hEOMES" EXACT PRO-short-label [PRO:DNx] synonym: "T-box brain protein 2 (human)" EXACT [UniProtKB:O95936] synonym: "T-brain-2 (human)" EXACT [UniProtKB:O95936] synonym: "TBR-2 (human)" EXACT [UniProtKB:O95936] synonym: "TBR2" RELATED Gene-based [UniProtKB:O95936] xref: Reactome:R-HSA-452232 "PR:O95936 located_in GO:0005654" xref: UniProtKB:O95936 is_a: PR:000003463 ! eomesodermin is_a: PR:000029067 ! Homo sapiens protein intersection_of: PR:000003463 ! eomesodermin intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:O95944 name: natural cytotoxicity triggering receptor 2 (human) namespace: protein def: "A natural cytotoxicity triggering receptor 2 that is encoded in the genome of human." [PRO:WCB, UniProtKB:O95944] comment: Category=organism-gene. synonym: "CD336 (human)" EXACT [UniProtKB:O95944] synonym: "hNCR2" EXACT PRO-short-label [PRO:DNx] synonym: "LY95" RELATED Gene-based [UniProtKB:O95944] synonym: "lymphocyte antigen 95 homolog (human)" EXACT [UniProtKB:O95944] synonym: "natural killer cell p44-related protein (human)" EXACT [UniProtKB:O95944] synonym: "NCR2" RELATED Gene-based [UniProtKB:O95944] synonym: "NK cell-activating receptor (human)" BROAD [UniProtKB:O95944] synonym: "NK-p44 (human)" EXACT [UniProtKB:O95944] synonym: "NKp44 (human)" EXACT [UniProtKB:O95944] xref: UniProtKB:O95944 is_a: PR:000001894 ! natural cytotoxicity triggering receptor 2 is_a: PR:000029067 ! Homo sapiens protein intersection_of: PR:000001894 ! natural cytotoxicity triggering receptor 2 intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:O95971 name: CD160 antigen (human) namespace: protein def: "A CD160 molecule that is encoded in the genome of human." [PRO:CNA, UniProtKB:O95971] comment: Category=organism-gene. synonym: "BY55" RELATED Gene-based [UniProtKB:O95971] synonym: "CD160" RELATED Gene-based [UniProtKB:O95971] synonym: "hCD160" EXACT PRO-short-label [PRO:DNx] synonym: "natural killer cell receptor BY55 (human)" EXACT [UniProtKB:O95971] xref: UniProtKB:O95971 is_a: PR:000001082 ! CD160 molecule is_a: PR:000029067 ! Homo sapiens protein intersection_of: PR:000001082 ! CD160 molecule intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:P00797 name: renin (human) namespace: protein def: "A renin that is encoded in the genome of human." [PRO:DNx, UniProtKB:P00797] comment: Category=organism-gene. synonym: "angiotensinogenase (human)" EXACT [UniProtKB:P00797] synonym: "hREN" EXACT PRO-short-label [PRO:DNx] synonym: "REN" RELATED Gene-based [UniProtKB:P00797] xref: UniProtKB:P00797 is_a: PR:000013883 ! renin is_a: PR:000029067 ! Homo sapiens protein intersection_of: PR:000013883 ! renin intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:P01100 name: protein c-Fos (human) namespace: protein def: "A protein c-Fos that is encoded in the genome of human." [PRO:DNx, UniProtKB:P01100] comment: Category=organism-gene. synonym: "cellular oncogene fos (human)" EXACT [UniProtKB:P01100] synonym: "FOS" RELATED Gene-based [UniProtKB:P01100] synonym: "Fos proto-oncogene, AP-1 transcription factor subunit (human)" EXACT [UniProtKB:P01100] synonym: "G0/G1 switch regulatory protein 7 (human)" EXACT [UniProtKB:P01100] synonym: "G0S7" RELATED Gene-based [UniProtKB:P01100] synonym: "hFOS" EXACT PRO-short-label [PRO:DNx] synonym: "proto-oncogene c-Fos (human)" EXACT [UniProtKB:P01100] synonym: "transcription factor AP-1 subunit c-Fos (human)" EXACT [UniProtKB:P01100] xref: Reactome:R-HSA-450216 "PR:P01100 located_in GO:0005654" xref: UniProtKB:P01100 is_a: PR:000007597 ! protein c-Fos is_a: PR:000029067 ! Homo sapiens protein intersection_of: PR:000007597 ! protein c-Fos intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:P01101 name: protein c-Fos (mouse) namespace: protein def: "A protein c-Fos that is encoded in the genome of mouse." [OMA:P01101, PRO:DNx] comment: Category=organism-gene. synonym: "cellular oncogene fos (mouse)" EXACT [UniProtKB:P01101] synonym: "FBJ osteosarcoma oncogene (mouse)" EXACT [UniProtKB:P01101] synonym: "Fos" RELATED Gene-based [UniProtKB:P01101] synonym: "mFOS" EXACT PRO-short-label [PRO:DNx] synonym: "transcription factor AP-1 subunit c-Fos (mouse)" EXACT [UniProtKB:P01101] xref: UniProtKB:P01101 is_a: PR:000007597 ! protein c-Fos is_a: PR:000029032 ! Mus musculus protein intersection_of: PR:000007597 ! protein c-Fos intersection_of: RO:0002160 NCBITaxon:10090 ! only in taxon Mus musculus [Term] id: PR:P01189 name: pro-opiomelanocortin (human) namespace: protein def: "A pro-opiomelanocortin that is encoded in the genome of human." [PRO:DNx, UniProtKB:P01189] comment: Category=organism-gene. synonym: "corticotropin-lipotropin (human)" EXACT [UniProtKB:P01189] synonym: "hPOMC" EXACT PRO-short-label [PRO:DNx] synonym: "POMC" RELATED Gene-based [UniProtKB:P01189] xref: UniProtKB:P01189 is_a: PR:000013015 ! pro-opiomelanocortin is_a: PR:000029067 ! Homo sapiens protein intersection_of: PR:000013015 ! pro-opiomelanocortin intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:P01193 name: pro-opiomelanocortin (mouse) namespace: protein def: "A pro-opiomelanocortin that is encoded in the genome of mouse." [OMA:P01193, PRO:DNx] comment: Category=organism-gene. synonym: "corticotropin-lipotropin (mouse)" EXACT [UniProtKB:P01193] synonym: "mPOMC" EXACT PRO-short-label [PRO:DNx] synonym: "Pomc" RELATED Gene-based [UniProtKB:P01193] synonym: "POMC (mouse)" EXACT [UniProtKB:P01193] synonym: "Pomc1" RELATED Gene-based [UniProtKB:P01193] xref: UniProtKB:P01193 is_a: PR:000013015 ! pro-opiomelanocortin is_a: PR:000029032 ! Mus musculus protein intersection_of: PR:000013015 ! pro-opiomelanocortin intersection_of: RO:0002160 NCBITaxon:10090 ! only in taxon Mus musculus [Term] id: PR:P01210 name: proenkephalin-A (human) namespace: protein def: "A proenkephalin-A that is encoded in the genome of human." [PRO:DNx, UniProtKB:P01210] comment: Category=organism-gene. synonym: "hPENK" EXACT PRO-short-label [PRO:DNx] synonym: "PENK" RELATED Gene-based [UniProtKB:P01210] xref: UniProtKB:P01210 is_a: PR:000012544 ! proenkephalin-A is_a: PR:000029067 ! Homo sapiens protein intersection_of: PR:000012544 ! proenkephalin-A intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:P01213 name: proenkephalin-B (human) namespace: protein def: "A proenkephalin-B that is encoded in the genome of human." [PRO:DNx, UniProtKB:P01213] comment: Category=organism-gene. synonym: "beta-neoendorphin-dynorphin (human)" EXACT [UniProtKB:P01213] synonym: "hPDYN" EXACT PRO-short-label [PRO:DNx] synonym: "PDYN" RELATED Gene-based [UniProtKB:P01213] synonym: "preprodynorphin (human)" EXACT [UniProtKB:P01213] xref: UniProtKB:P01213 is_a: PR:000012526 ! proenkephalin-B is_a: PR:000029067 ! Homo sapiens protein intersection_of: PR:000012526 ! proenkephalin-B intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:P01236 name: prolactin (human) namespace: protein def: "A prolactin that is encoded in the genome of human." [PRO:DNx, UniProtKB:P01236] comment: Category=organism-gene. synonym: "hPRL" EXACT PRO-short-label [PRO:DNx] synonym: "PRL" RELATED Gene-based [UniProtKB:P01236] xref: UniProtKB:P01236 is_a: PR:000013246 ! prolactin is_a: PR:000029067 ! Homo sapiens protein intersection_of: PR:000013246 ! prolactin intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:P01282 name: VIP peptides (human) namespace: protein def: "A VIP peptides that is encoded in the genome of human." [PRO:DNx, UniProtKB:P01282] comment: Category=organism-gene. synonym: "hVIP" EXACT PRO-short-label [PRO:DNx] synonym: "vasoactive intestinal peptides (human)" EXACT [PRO:DAN] synonym: "vasoactive intestinal polypeptides (human)" EXACT [PRO:DAN] synonym: "VIP" RELATED Gene-based [UniProtKB:P01282] xref: UniProtKB:P01282 is_a: PR:000017299 ! VIP peptides is_a: PR:000029067 ! Homo sapiens protein intersection_of: PR:000017299 ! VIP peptides intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:P01303 name: pro-neuropeptide Y (human) namespace: protein def: "A neuropeptide Y that is encoded in the genome of human." [PRO:DNx, UniProtKB:P01303] comment: Category=organism-gene. synonym: "hNPY" EXACT PRO-short-label [PRO:DNx] synonym: "NPY" RELATED Gene-based [UniProtKB:P01303] xref: UniProtKB:P01303 is_a: PR:000011387 ! neuropeptide Y is_a: PR:000029067 ! Homo sapiens protein intersection_of: PR:000011387 ! neuropeptide Y intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:P01308 name: preproinsulin (human) namespace: protein def: "A preproinsulin that is encoded in the genome of human." [PRO:DAN, UniProtKB:P01308] comment: Category=organism-gene. synonym: "hINS" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:P01308 is_a: PR:000009054 ! preproinsulin is_a: PR:000029067 ! Homo sapiens protein intersection_of: PR:000009054 ! preproinsulin intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:P01589 name: interleukin-2 receptor subunit alpha (human) namespace: protein def: "An interleukin-2 receptor subunit alpha that is encoded in the genome of human." [PRO:CNA, UniProtKB:P01589] comment: Category=organism-gene. synonym: "CD25 (human)" EXACT [UniProtKB:P01589] synonym: "hIL2RA" EXACT PRO-short-label [PRO:DNx] synonym: "IL-2 receptor subunit alpha (human)" EXACT [UniProtKB:P01589] synonym: "IL-2-RA (human)" EXACT [UniProtKB:P01589] synonym: "IL-2R subunit alpha (human)" EXACT [UniProtKB:P01589] synonym: "IL2-RA (human)" EXACT [UniProtKB:P01589] synonym: "IL2RA" RELATED Gene-based [UniProtKB:P01589] synonym: "p55 (human)" BROAD [UniProtKB:P01589] synonym: "TAC antigen (human)" EXACT [UniProtKB:P01589] xref: UniProtKB:P01589 is_a: PR:000001380 ! interleukin-2 receptor subunit alpha is_a: PR:000029067 ! Homo sapiens protein intersection_of: PR:000001380 ! interleukin-2 receptor subunit alpha intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:P01590 name: interleukin-2 receptor subunit alpha (mouse) namespace: protein def: "An interleukin-2 receptor subunit alpha that is encoded in the genome of mouse." [OMA:P01590, PRO:DNx] comment: Category=organism-gene. synonym: "CD25 (mouse)" EXACT [UniProtKB:P01590] synonym: "IL-2 receptor subunit alpha (mouse)" EXACT [UniProtKB:P01590] synonym: "IL-2-RA (mouse)" EXACT [UniProtKB:P01590] synonym: "IL-2R subunit alpha (mouse)" EXACT [UniProtKB:P01590] synonym: "IL2-RA (mouse)" EXACT [UniProtKB:P01590] synonym: "Il2r" RELATED Gene-based [UniProtKB:P01590] synonym: "Il2ra" RELATED Gene-based [UniProtKB:P01590] synonym: "mIL2RA" EXACT PRO-short-label [PRO:DNx] synonym: "p55 (mouse)" BROAD [UniProtKB:P01590] xref: UniProtKB:P01590 is_a: PR:000001380 ! interleukin-2 receptor subunit alpha is_a: PR:000029032 ! Mus musculus protein intersection_of: PR:000001380 ! interleukin-2 receptor subunit alpha intersection_of: RO:0002160 NCBITaxon:10090 ! only in taxon Mus musculus [Term] id: PR:P01730 name: T-cell surface glycoprotein CD4 (human) namespace: protein def: "A CD4 molecule that is encoded in the genome of human." [PRO:DNx, UniProtKB:P01730] comment: Category=organism-gene. synonym: "CD4" RELATED Gene-based [UniProtKB:P01730] synonym: "hCD4" EXACT PRO-short-label [PRO:DNx] synonym: "T-cell surface antigen T4/Leu-3 (human)" EXACT [UniProtKB:P01730] xref: UniProtKB:P01730 is_a: PR:000001004 ! CD4 molecule is_a: PR:000029067 ! Homo sapiens protein intersection_of: PR:000001004 ! CD4 molecule intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:P01731 name: T-cell surface glycoprotein CD8 alpha chain (mouse) namespace: protein def: "A T-cell surface glycoprotein CD8 alpha chain that is encoded in the genome of mouse." [OMA:P01731, PRO:DNx] comment: Category=organism-gene. synonym: "Cd8a" RELATED Gene-based [UniProtKB:P01731] synonym: "CD8a (mouse)" EXACT [UniProtKB:P01731] synonym: "Lyt-2" RELATED Gene-based [UniProtKB:P01731] synonym: "Lyt2" RELATED Gene-based [UniProtKB:P01731] synonym: "mCD8A" EXACT PRO-short-label [PRO:DNx] synonym: "T-cell surface glycoprotein Lyt-2 (mouse)" EXACT [UniProtKB:P01731] xref: UniProtKB:P01731 is_a: PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain is_a: PR:000029032 ! Mus musculus protein intersection_of: PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain intersection_of: RO:0002160 NCBITaxon:10090 ! only in taxon Mus musculus [Term] id: PR:P01732 name: T-cell surface glycoprotein CD8 alpha chain (human) namespace: protein def: "A T-cell surface glycoprotein CD8 alpha chain that is encoded in the genome of human." [PRO:CNA, UniProtKB:P01732] comment: Category=organism-gene. synonym: "CD8A" RELATED Gene-based [UniProtKB:P01732] synonym: "CD8a (human)" EXACT [UniProtKB:P01732] synonym: "hCD8A" EXACT PRO-short-label [PRO:DNx] synonym: "MAL" RELATED Gene-based [UniProtKB:P01732] synonym: "T-lymphocyte differentiation antigen T8/Leu-2 (human)" EXACT [UniProtKB:P01732] xref: UniProtKB:P01732 is_a: PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain is_a: PR:000029067 ! Homo sapiens protein intersection_of: PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:P01732-1 name: T-cell surface glycoprotein CD8 alpha chain isoform 1 (human) namespace: protein def: "A T-cell surface glycoprotein CD8 alpha chain isoform 1 that is encoded in the genome of human." [PRO:DAN] comment: Category=organism-sequence. synonym: "hCD8A/iso:1" EXACT PRO-short-label [PRO:DNx] synonym: "T-cell surface glycoprotein CD8 alpha chain isoform mCD8alpha (human)" EXACT [UniProtKB:P01732] synonym: "T-cell surface glycoprotein CD8 alpha chain isoform membrane (human)" EXACT [UniProtKB:P01732] xref: UniProtKB:P01732-1 is_a: PR:000025403 ! T-cell surface glycoprotein CD8 alpha chain isoform 1 is_a: PR:P01732 ! T-cell surface glycoprotein CD8 alpha chain (human) intersection_of: PR:000025403 ! T-cell surface glycoprotein CD8 alpha chain isoform 1 intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:P01831 name: Thy-1 membrane glycoprotein (mouse) namespace: protein def: "A Thy-1 membrane glycoprotein that is encoded in the genome of mouse." [OMA:P01831, PRO:DNx] comment: Category=organism-gene. synonym: "CD90 (mouse)" EXACT [UniProtKB:P01831] synonym: "mTHY1" EXACT PRO-short-label [PRO:DNx] synonym: "Thy-1" RELATED Gene-based [UniProtKB:P01831] synonym: "Thy-1 antigen (mouse)" EXACT [UniProtKB:P01831] synonym: "Thy1" RELATED Gene-based [UniProtKB:P01831] xref: UniProtKB:P01831 is_a: PR:000001843 ! Thy-1 membrane glycoprotein is_a: PR:000029032 ! Mus musculus protein intersection_of: PR:000001843 ! Thy-1 membrane glycoprotein intersection_of: RO:0002160 NCBITaxon:10090 ! only in taxon Mus musculus [Term] id: PR:P01903 name: HLA class II histocompatibility antigen, DR alpha chain (human) namespace: protein def: "An MHC class II histocompatibility antigen alpha chain DRA that is encoded in the genome of human." [PRO:WCB, UniProtKB:P01903] comment: Category=organism-gene. Requested by=IEDB. synonym: "hHLA-DRA" EXACT PRO-short-label [PRO:DNx] synonym: "HLA-DRA" RELATED Gene-based [UniProtKB:P01903] synonym: "HLA-DRA chain" EXACT [MRO:0000693] synonym: "HLA-DRA1" RELATED Gene-based [UniProtKB:P01903] synonym: "MHC class II antigen DRA (human)" EXACT [UniProtKB:P01903] xref: MRO:0000693 xref: UniProtKB:P01903 is_a: PR:000002015 ! MHC class II histocompatibility antigen alpha chain DRA is_a: PR:000029067 ! Homo sapiens protein intersection_of: PR:000002015 ! MHC class II histocompatibility antigen alpha chain DRA intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:P02008 name: hemoglobin subunit zeta (human) namespace: protein def: "A hemoglobin subunit zeta that is encoded in the genome of human." [PRO:DNx, UniProtKB:P02008] comment: Category=organism-gene. synonym: "HBAZ (human)" EXACT [UniProtKB:P02008] synonym: "HBZ" RELATED Gene-based [UniProtKB:P02008] synonym: "HBZ2" RELATED Gene-based [UniProtKB:P02008] synonym: "hemoglobin zeta chain (human)" EXACT [UniProtKB:P02008] synonym: "hHBZ" EXACT PRO-short-label [PRO:DNx] synonym: "zeta-globin (human)" EXACT [UniProtKB:P02008] xref: UniProtKB:P02008 is_a: PR:000008467 ! hemoglobin subunit zeta is_a: PR:000029067 ! Homo sapiens protein intersection_of: PR:000008467 ! hemoglobin subunit zeta intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:P02088 name: hemoglobin subunit beta-1 (mouse) namespace: protein def: "A hemoglobin subunit beta-1 that is encoded in the genome of mouse." [PRO:DNx, UniProtKB:P02088] comment: Category=organism-gene. synonym: "beta-1-globin (mouse)" EXACT [UniProtKB:P02088] synonym: "Hbb-b1" RELATED Gene-based [UniProtKB:P02088] synonym: "hemoglobin beta-1 chain (mouse)" EXACT [UniProtKB:P02088] synonym: "hemoglobin beta-major chain (mouse)" EXACT [UniProtKB:P02088] synonym: "mHbb-b1" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:P02088 is_a: PR:000008857 ! hemoglobin subunit beta-1 is_a: PR:000029032 ! Mus musculus protein intersection_of: PR:000008857 ! hemoglobin subunit beta-1 intersection_of: RO:0002160 NCBITaxon:10090 ! only in taxon Mus musculus [Term] id: PR:P02452 name: collagen alpha-1(I) chain (human) namespace: protein def: "A collagen alpha-1(I) chain that is encoded in the genome of human." [PRO:CNA, UniProtKB:P02452] comment: Category=organism-gene. synonym: "alpha-1 type I collagen (human)" EXACT [UniProtKB:P02452] synonym: "COL1A1" RELATED Gene-based [UniProtKB:P02452] synonym: "hCOL1A1" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:P02452 is_a: PR:000003264 ! collagen alpha-1(I) chain is_a: PR:000029067 ! Homo sapiens protein intersection_of: PR:000003264 ! collagen alpha-1(I) chain intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:P02461 name: collagen alpha-1(III) chain (human) namespace: protein def: "A collagen alpha-1(III) chain that is encoded in the genome of human." [PRO:CNA, UniProtKB:P02461] comment: Category=organism-gene. synonym: "COL3A1" RELATED Gene-based [UniProtKB:P02461] synonym: "hCOL3A1" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:P02461 is_a: PR:000003328 ! collagen alpha-1(III) chain is_a: PR:000029067 ! Homo sapiens protein intersection_of: PR:000003328 ! collagen alpha-1(III) chain intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:P02724 name: glycophorin-A (human) namespace: protein def: "A glycophorin-A that is encoded in the genome of human." [PRO:CNA, UniProtKB:P02724] comment: Category=organism-gene. synonym: "CD235a (human)" EXACT [UniProtKB:P02724] synonym: "GPA" RELATED Gene-based [UniProtKB:P02724] synonym: "GYPA" RELATED Gene-based [UniProtKB:P02724] synonym: "hGYPA" EXACT PRO-short-label [PRO:DNx] synonym: "MN sialoglycoprotein (human)" EXACT [UniProtKB:P02724] synonym: "MNS" RELATED Gene-based [UniProtKB:P02724] synonym: "PAS-2 (human)" EXACT [UniProtKB:P02724] synonym: "sialoglycoprotein alpha (human)" EXACT [UniProtKB:P02724] xref: UniProtKB:P02724 is_a: PR:000001460 ! glycophorin-A is_a: PR:000029067 ! Homo sapiens protein intersection_of: PR:000001460 ! glycophorin-A intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:P02786 name: transferrin receptor protein 1 (human) namespace: protein def: "A transferrin receptor protein 1 that is encoded in the genome of human." [PRO:WCB, UniProtKB:P02786] comment: Category=organism-gene. synonym: "CD71 (human)" EXACT [UniProtKB:P02786] synonym: "hTFRC" EXACT PRO-short-label [PRO:DNx] synonym: "p90 (human)" BROAD [UniProtKB:P02786] synonym: "T9 (human)" EXACT [UniProtKB:P02786] synonym: "TfR (human)" EXACT [UniProtKB:P02786] synonym: "TfR1 (human)" EXACT [UniProtKB:P02786] synonym: "TFRC" RELATED Gene-based [UniProtKB:P02786] synonym: "TR (human)" BROAD [UniProtKB:P02786] synonym: "Trfr (human)" EXACT [UniProtKB:P02786] xref: Reactome:R-HSA-434196 "PR:P02786 located_in GO:0030659" xref: Reactome:R-HSA-434330 "PR:P02786 located_in GO:0000139" xref: Reactome:R-HSA-8869124 "PR:P02786 located_in GO:0030665" xref: Reactome:R-HSA-8961829 "PR:P02786 located_in GO:0010008" xref: Reactome:R-HSA-917983 "PR:P02786 located_in GO:0005886" xref: UniProtKB:P02786 is_a: PR:000001945 ! transferrin receptor protein 1 is_a: PR:000029067 ! Homo sapiens protein intersection_of: PR:000001945 ! transferrin receptor protein 1 intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:P02788 name: lactotransferrin (human) namespace: protein def: "A lactotransferrin that is encoded in the genome of human." [PRO:DNx, UniProtKB:P02788] comment: Category=organism-gene. synonym: "GIG12" RELATED Gene-based [UniProtKB:P02788] synonym: "growth-inhibiting protein 12 (human)" EXACT [UniProtKB:P02788] synonym: "hLTF" EXACT PRO-short-label [PRO:DNx] synonym: "lactoferrin (human)" EXACT [UniProtKB:P02788] synonym: "LF" RELATED Gene-based [UniProtKB:P02788] synonym: "LTF" RELATED Gene-based [UniProtKB:P02788] synonym: "talalactoferrin (human)" EXACT [UniProtKB:P02788] xref: UniProtKB:P02788 is_a: PR:000009978 ! lactotransferrin is_a: PR:000029067 ! Homo sapiens protein intersection_of: PR:000009978 ! lactotransferrin intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:P03372 name: estrogen receptor (human) namespace: protein def: "An estrogen receptor that is encoded in the genome of human." [PRO:DNx, UniProtKB:P03372] comment: Category=organism-gene. synonym: "ER (human)" EXACT [UniProtKB:P03372] synonym: "ER-alpha (human)" EXACT [UniProtKB:P03372] synonym: "ESR" RELATED Gene-based [UniProtKB:P03372] synonym: "ESR1" RELATED Gene-based [UniProtKB:P03372] synonym: "estradiol receptor (human)" EXACT [UniProtKB:P03372] synonym: "hESR1" EXACT PRO-short-label [PRO:DNx] synonym: "NR3A1" RELATED Gene-based [UniProtKB:P03372] synonym: "nuclear receptor subfamily 3 group A member 1 (human)" EXACT [UniProtKB:P03372] xref: DTO:00117511 xref: Reactome:R-HSA-446168 "PR:P03372 located_in GO:0005654" xref: Reactome:R-HSA-9020968 "PR:P03372 located_in GO:0005829" xref: UniProtKB:P03372 is_a: PR:000007204 ! estrogen receptor is_a: PR:000029067 ! Homo sapiens protein intersection_of: PR:000007204 ! estrogen receptor intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:P03995 name: glial fibrillary acidic protein (mouse) namespace: protein def: "A glial fibrillary acidic protein that is encoded in the genome of mouse." [OMA:P03995, PRO:DNx] comment: Category=organism-gene. synonym: "Gfap" RELATED Gene-based [UniProtKB:P03995] synonym: "GFAP (mouse)" EXACT [UniProtKB:P03995] synonym: "mGFAP" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:P03995 is_a: PR:000007939 ! glial fibrillary acidic protein is_a: PR:000029032 ! Mus musculus protein intersection_of: PR:000007939 ! glial fibrillary acidic protein intersection_of: RO:0002160 NCBITaxon:10090 ! only in taxon Mus musculus [Term] id: PR:P04000 name: long-wave-sensitive opsin 1 (human) namespace: protein def: "A long-wave-sensitive opsin 1 that is encoded in the genome of human." [PRO:WCB, UniProtKB:P04000] comment: Category=organism-gene. synonym: "hOPN1LW" EXACT PRO-short-label [PRO:DNx] synonym: "OPN1LW" RELATED Gene-based [UniProtKB:P04000] synonym: "RCP" RELATED Gene-based [UniProtKB:P04000] synonym: "red cone photoreceptor pigment (human)" EXACT [UniProtKB:P04000] synonym: "red-sensitive opsin (human)" EXACT [UniProtKB:P04000] synonym: "ROP (human)" EXACT [UniProtKB:P04000] xref: DTO:02100475 xref: Reactome:R-HSA-419769 "PR:P04000 located_in GO:0042622" xref: UniProtKB:P04000 is_a: PR:000001244 ! long-wave-sensitive opsin 1 is_a: PR:000029067 ! Homo sapiens protein intersection_of: PR:000001244 ! long-wave-sensitive opsin 1 intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:P04001 name: medium-wave-sensitive opsin 1 (human) namespace: protein def: "A medium-wave-sensitive opsin (human) that is a translation product of the OPN1MW gene in human." [PRO:DAN, UniProtKB:P04001] comment: Category=organism-gene. Note: The proteins encoded by OPN1MW (this class), OPN1MW2 (PR:P0DN77), and OPN1MW3 (PR:P0DN78) are identical. synonym: "GCP" RELATED Gene-based [UniProtKB:P04001] synonym: "GOP (human)" BROAD [UniProtKB:P04001] synonym: "green cone photoreceptor pigment (human)" BROAD [UniProtKB:P04001] synonym: "green-sensitive opsin (human)" BROAD [UniProtKB:P04001] synonym: "hOPN1MW1" EXACT PRO-short-label [PRO:DNx] synonym: "OPN1MW" RELATED Gene-based [UniProtKB:P04001] xref: DTO:02100474 xref: Reactome:R-HSA-391835 "PR:P04001 located_in GO:0097381" xref: UniProtKB:P04001 is_a: PR:000050522 ! medium-wave-sensitive opsin (human) [Term] id: PR:P04053 name: DNA nucleotidylexotransferase (human) namespace: protein def: "A DNA nucleotidylexotransferase that is encoded in the genome of human." [PRO:DNx, UniProtKB:P04053] comment: Category=organism-gene. synonym: "DNTT" RELATED Gene-based [UniProtKB:P04053] synonym: "hDNTT" EXACT PRO-short-label [PRO:DNx] synonym: "TDT" RELATED Gene-based [UniProtKB:P04053] synonym: "terminal addition enzyme (human)" EXACT [UniProtKB:P04053] synonym: "terminal deoxynucleotidyltransferase (human)" EXACT [UniProtKB:P04053] synonym: "terminal transferase (human)" BROAD [UniProtKB:P04053] xref: UniProtKB:P04053 is_a: PR:000006611 ! DNA nucleotidylexotransferase is_a: PR:000029067 ! Homo sapiens protein intersection_of: PR:000006611 ! DNA nucleotidylexotransferase intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:P04216 name: Thy-1 membrane glycoprotein (human) namespace: protein def: "A Thy-1 membrane glycoprotein that is encoded in the genome of human." [PRO:WCB, UniProtKB:P04216] comment: Category=organism-gene. synonym: "CD90 (human)" EXACT [UniProtKB:P04216] synonym: "CDw90 (human)" EXACT [UniProtKB:P04216] synonym: "hTHY1" EXACT PRO-short-label [PRO:DNx] synonym: "Thy-1 antigen (human)" EXACT [UniProtKB:P04216] synonym: "THY1" RELATED Gene-based [UniProtKB:P04216] xref: UniProtKB:P04216 is_a: PR:000001843 ! Thy-1 membrane glycoprotein is_a: PR:000029067 ! Homo sapiens protein intersection_of: PR:000001843 ! Thy-1 membrane glycoprotein intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:P04271 name: protein S100-B (human) namespace: protein def: "A protein S100-B that is encoded in the genome of human." [PRO:DNx, UniProtKB:P04271] comment: Category=organism-gene. synonym: "hS100B" EXACT PRO-short-label [PRO:DNx] synonym: "S-100 protein beta chain (human)" EXACT [UniProtKB:P04271] synonym: "S-100 protein subunit beta (human)" EXACT [UniProtKB:P04271] synonym: "S100 calcium-binding protein B (human)" EXACT [UniProtKB:P04271] synonym: "S100B" RELATED Gene-based [UniProtKB:P04271] xref: UniProtKB:P04271 is_a: PR:000014419 ! protein S100-B is_a: PR:000029067 ! Homo sapiens protein intersection_of: PR:000014419 ! protein S100-B intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:P05089 name: arginase-1 (human) namespace: protein def: "An arginase-1 that is encoded in the genome of human." [PRO:WCB, UniProtKB:P05089] comment: Category=organism-gene. synonym: "ARG1" RELATED Gene-based [UniProtKB:P05089] synonym: "hARG1" EXACT PRO-short-label [PRO:DNx] synonym: "liver-type arginase (human)" EXACT [UniProtKB:P05089] synonym: "type I arginase (human)" EXACT [UniProtKB:P05089] xref: Reactome:R-HSA-6798764 "PR:P05089 located_in GO:0035578" xref: Reactome:R-HSA-6801011 "PR:P05089 located_in GO:0035580" xref: Reactome:R-HSA-6806221 "PR:P05089 located_in GO:0005576" xref: Reactome:R-HSA-70561 "PR:P05089 located_in GO:0005829" xref: UniProtKB:P05089 is_a: PR:000001844 ! arginase-1 is_a: PR:000029067 ! Homo sapiens protein intersection_of: PR:000001844 ! arginase-1 intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:P05164 name: myeloperoxidase (human) namespace: protein def: "A myeloperoxidase that is encoded in the genome of human." [PRO:DNx, UniProtKB:P05164] comment: Category=organism-gene. synonym: "hMPO" EXACT PRO-short-label [PRO:DNx] synonym: "MPO" RELATED Gene-based [UniProtKB:P05164] xref: UniProtKB:P05164 is_a: PR:000010543 ! myeloperoxidase is_a: PR:000029067 ! Homo sapiens protein intersection_of: PR:000010543 ! myeloperoxidase intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:P05230 name: fibroblast growth factor 1 (human) namespace: protein def: "A fibroblast growth factor 1 that is encoded in the genome of human." [PRO:DNx, UniProtKB:P05230] comment: Category=organism-gene. synonym: "acidic fibroblast growth factor (human)" EXACT [UniProtKB:P05230] synonym: "aFGF (human)" EXACT [UniProtKB:P05230] synonym: "ECGF (human)" EXACT [UniProtKB:P05230] synonym: "endothelial cell growth factor (human)" EXACT [UniProtKB:P05230] synonym: "FGF-1 (human)" EXACT [UniProtKB:P05230] synonym: "FGF1" RELATED Gene-based [UniProtKB:P05230] synonym: "FGFA" RELATED Gene-based [UniProtKB:P05230] synonym: "HBGF-1 (human)" EXACT [UniProtKB:P05230] synonym: "heparin-binding growth factor 1 (human)" EXACT [UniProtKB:P05230] synonym: "hFGF1" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:P05230 is_a: PR:000007479 ! fibroblast growth factor 1 is_a: PR:000029067 ! Homo sapiens protein intersection_of: PR:000007479 ! fibroblast growth factor 1 intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:P05305 name: endothelin-1 (human) namespace: protein def: "An endothelin-1 that is encoded in the genome of human." [PRO:DNx, UniProtKB:P05305] comment: Category=organism-gene. synonym: "EDN1" RELATED Gene-based [UniProtKB:P05305] synonym: "hEDN1" EXACT PRO-short-label [PRO:DNx] synonym: "PPET1 (human)" EXACT [UniProtKB:P05305] synonym: "preproendothelin-1 (human)" EXACT [UniProtKB:P05305] xref: UniProtKB:P05305 is_a: PR:000006897 ! endothelin-1 is_a: PR:000029067 ! Homo sapiens protein intersection_of: PR:000006897 ! endothelin-1 intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:P05532 name: mast/stem cell growth factor receptor Kit (mouse) namespace: protein def: "A mast/stem cell growth factor receptor that is encoded in the genome of mouse." [OMA:MOUSE17014, PRO:DNx] comment: Category=organism-gene. synonym: "CD117 (mouse)" EXACT [UniProtKB:P05532] synonym: "Kit" RELATED Gene-based [UniProtKB:P05532] synonym: "mKIT" EXACT PRO-short-label [PRO:DNx] synonym: "proto-oncogene c-Kit (mouse)" EXACT [UniProtKB:P05532] synonym: "SCFR (mouse)" EXACT [UniProtKB:P05532] synonym: "Sl" RELATED Gene-based [UniProtKB:P05532] synonym: "tyrosine-protein kinase Kit (mouse)" EXACT [UniProtKB:P05532] xref: UniProtKB:P05532 is_a: PR:000002065 ! mast/stem cell growth factor receptor is_a: PR:000029032 ! Mus musculus protein intersection_of: PR:000002065 ! mast/stem cell growth factor receptor intersection_of: RO:0002160 NCBITaxon:10090 ! only in taxon Mus musculus [Term] id: PR:P05533 name: lymphocyte antigen 6A-2/6E-1 (mouse) namespace: protein def: "A lymphocyte antigen 6A-2/6E-1 that is encoded in the genome of mouse." [PRO:CNA, UniProtKB:P05533] comment: Category=organism-gene. synonym: "Ly-6A.2/Ly-6E.1 (mouse)" EXACT [UniProtKB:P05533] synonym: "Ly6" RELATED Gene-based [UniProtKB:P05533] synonym: "Ly6a" RELATED Gene-based [UniProtKB:P05533] synonym: "mLy6a" EXACT PRO-short-label [PRO:DNx] synonym: "SCA-1 (mouse)" EXACT [UniProtKB:P05533] synonym: "Stem cell antigen 1 (mouse)" EXACT [UniProtKB:P05533] synonym: "T-cell-activating protein (mouse)" EXACT [UniProtKB:P05533] synonym: "TAP (mouse)" BROAD [UniProtKB:P05533] xref: UniProtKB:P05533 is_a: PR:000002979 ! lymphocyte antigen 6A-2/6E-1 is_a: PR:000029032 ! Mus musculus protein intersection_of: PR:000002979 ! lymphocyte antigen 6A-2/6E-1 intersection_of: RO:0002160 NCBITaxon:10090 ! only in taxon Mus musculus [Term] id: PR:P05555 name: integrin alpha-M (mouse) namespace: protein def: "An integrin alpha-M that is encoded in the genome of mouse." [PRO:DNx, UniProtKB:P05555] comment: Category=organism-gene. synonym: "CD11 antigen-like family member B (mouse)" EXACT [UniProtKB:P05555] synonym: "CD11b (mouse)" EXACT [UniProtKB:P05555] synonym: "cell surface glycoprotein MAC-1 subunit alpha (mouse)" EXACT [UniProtKB:P05555] synonym: "CR-3 alpha chain (mouse)" EXACT [UniProtKB:P05555] synonym: "Itgam" RELATED Gene-based [UniProtKB:P05555] synonym: "leukocyte adhesion receptor MO1 (mouse)" EXACT [UniProtKB:P05555] synonym: "mITGAM" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:P05555 is_a: PR:000001012 ! integrin alpha-M is_a: PR:000029032 ! Mus musculus protein intersection_of: PR:000001012 ! integrin alpha-M intersection_of: RO:0002160 NCBITaxon:10090 ! only in taxon Mus musculus [Term] id: PR:P06126 name: T-cell surface glycoprotein CD1a (human) namespace: protein def: "A T-cell surface glycoprotein CD1a that is encoded in the genome of human." [PRO:WCB, UniProtKB:P06126] comment: Category=organism-gene. synonym: "CD1A" RELATED Gene-based [UniProtKB:P06126] synonym: "CD1a (human)" EXACT [UniProtKB:P06126] synonym: "hCD1A" EXACT PRO-short-label [PRO:DNx] synonym: "hTa1 thymocyte antigen" EXACT [UniProtKB:P06126] synonym: "human CD1a chain" EXACT [MRO:0000888] synonym: "T-cell surface antigen T6/Leu-6 (human)" EXACT [UniProtKB:P06126] xref: MRO:0000888 xref: UniProtKB:P06126 is_a: PR:000002025 ! T-cell surface glycoprotein CD1a is_a: PR:000036947 ! T-cell surface glycoprotein CD1 (human) intersection_of: PR:000002025 ! T-cell surface glycoprotein CD1a intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:P06127 name: T-cell surface glycoprotein CD5 (human) namespace: protein def: "A T-cell surface glycoprotein CD5 that is encoded in the genome of human." [PRO:WCB, UniProtKB:P06127] comment: Category=organism-gene. synonym: "CD5" RELATED Gene-based [UniProtKB:P06127] synonym: "hCD5" EXACT PRO-short-label [PRO:DNx] synonym: "LEU1" RELATED Gene-based [UniProtKB:P06127] synonym: "lymphocyte antigen T1/Leu-1 (human)" EXACT [UniProtKB:P06127] xref: UniProtKB:P06127 is_a: PR:000001839 ! T-cell surface glycoprotein CD5 is_a: PR:000029067 ! Homo sapiens protein intersection_of: PR:000001839 ! T-cell surface glycoprotein CD5 intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:P06307 name: cholecystokinin (human) namespace: protein def: "A cholecystokinin that is encoded in the genome of human." [PRO:DNx, UniProtKB:P06307] comment: Category=organism-gene. synonym: "CCK" RELATED Gene-based [UniProtKB:P06307] synonym: "hCCK" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:P06307 is_a: PR:000005110 ! cholecystokinin is_a: PR:000029067 ! Homo sapiens protein intersection_of: PR:000005110 ! cholecystokinin intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:P06332 name: T-cell surface glycoprotein CD4 (mouse) namespace: protein def: "A CD4 molecule that is encoded in the genome of mouse." [OMA:P06332, PRO:DNx] comment: Category=organism-gene. synonym: "Cd4" RELATED Gene-based [UniProtKB:P06332] synonym: "CD4 (mouse)" EXACT [UniProtKB:P06332] synonym: "mCD4" EXACT PRO-short-label [PRO:DNx] synonym: "T-cell differentiation antigen L3T4 (mouse)" EXACT [UniProtKB:P06332] synonym: "T-cell surface antigen T4/Leu-3 (mouse)" EXACT [UniProtKB:P06332] xref: UniProtKB:P06332 is_a: PR:000001004 ! CD4 molecule is_a: PR:000029032 ! Mus musculus protein intersection_of: PR:000001004 ! CD4 molecule intersection_of: RO:0002160 NCBITaxon:10090 ! only in taxon Mus musculus [Term] id: PR:P06467 name: hemoglobin subunit zeta (mouse) namespace: protein def: "A hemoglobin subunit zeta that is encoded in the genome of mouse." [OMA:P06467, PRO:DNx] comment: Category=organism-gene. synonym: "alpha-like embryonic globin chain x (mouse)" EXACT [UniProtKB:P06467] synonym: "Hba-x" RELATED Gene-based [UniProtKB:P06467] synonym: "Hbz" RELATED Gene-based [UniProtKB:P06467] synonym: "Hbz1" RELATED Gene-based [UniProtKB:P06467] synonym: "hemoglobin zeta chain (mouse)" EXACT [UniProtKB:P06467] synonym: "mHBZ" EXACT PRO-short-label [PRO:DNx] synonym: "zeta-globin (mouse)" EXACT [UniProtKB:P06467] xref: UniProtKB:P06467 is_a: PR:000008467 ! hemoglobin subunit zeta is_a: PR:000029032 ! Mus musculus protein intersection_of: PR:000008467 ! hemoglobin subunit zeta intersection_of: RO:0002160 NCBITaxon:10090 ! only in taxon Mus musculus [Term] id: PR:P06729 name: T-cell surface antigen CD2 (human) namespace: protein def: "A CD2 molecule that is encoded in the genome of human." [PRO:CNA, UniProtKB:P06729] comment: Category=organism-gene. synonym: "CD2" RELATED Gene-based [UniProtKB:P06729] synonym: "erythrocyte receptor (human)" EXACT [UniProtKB:P06729] synonym: "hCD2" EXACT PRO-short-label [PRO:DNx] synonym: "LFA-2 (human)" EXACT [UniProtKB:P06729] synonym: "LFA-3 receptor (human)" EXACT [UniProtKB:P06729] synonym: "rosette receptor (human)" EXACT [UniProtKB:P06729] synonym: "SRBC" RELATED Gene-based [UniProtKB:P06729] synonym: "T-cell surface antigen T11/Leu-5 (human)" EXACT [UniProtKB:P06729] xref: UniProtKB:P06729 is_a: PR:000001083 ! CD2 molecule is_a: PR:000029067 ! Homo sapiens protein intersection_of: PR:000001083 ! CD2 molecule intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:P06734 name: low affinity immunoglobulin epsilon Fc receptor (human) namespace: protein def: "A low affinity immunoglobulin epsilon Fc receptor that is encoded in the genome of human." [PRO:WCB, UniProtKB:P06734] comment: Category=organism-gene. synonym: "BLAST-2 (human)" EXACT [UniProtKB:P06734] synonym: "C-type lectin domain family 4 member J (human)" EXACT [UniProtKB:P06734] synonym: "CD23 (human)" EXACT [UniProtKB:P06734] synonym: "CD23A" RELATED Gene-based [UniProtKB:P06734] synonym: "CLEC4J" RELATED Gene-based [UniProtKB:P06734] synonym: "Fc-epsilon-RII (human)" EXACT [UniProtKB:P06734] synonym: "FCE2" RELATED Gene-based [UniProtKB:P06734] synonym: "FCER2" RELATED Gene-based [UniProtKB:P06734] synonym: "hFCER2" EXACT PRO-short-label [PRO:DNx] synonym: "IGEBF" RELATED Gene-based [UniProtKB:P06734] synonym: "immunoglobulin E-binding factor (human)" EXACT [UniProtKB:P06734] synonym: "lymphocyte IgE receptor (human)" EXACT [UniProtKB:P06734] xref: Reactome:R-HSA-2127280 "PR:P06734 located_in GO:0005886" xref: UniProtKB:P06734 is_a: PR:000001880 ! low affinity immunoglobulin epsilon Fc receptor is_a: PR:000029067 ! Homo sapiens protein intersection_of: PR:000001880 ! low affinity immunoglobulin epsilon Fc receptor intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:P06800 name: receptor-type tyrosine-protein phosphatase C (mouse) namespace: protein def: "A receptor-type tyrosine-protein phosphatase C that is encoded in the genome of mouse." [OMA:P06800, PRO:DNx] comment: Category=organism-gene. synonym: "CD45 (mouse)" EXACT [UniProtKB:P06800] synonym: "L-CA (mouse)" EXACT [UniProtKB:P06800] synonym: "leukocyte common antigen (mouse)" EXACT [UniProtKB:P06800] synonym: "Ly-5" RELATED Gene-based [UniProtKB:P06800] synonym: "lymphocyte antigen 5 (mouse)" EXACT [UniProtKB:P06800] synonym: "mPTPRC" EXACT PRO-short-label [PRO:DNx] synonym: "Ptprc" RELATED Gene-based [UniProtKB:P06800] synonym: "T200 (mouse)" EXACT [UniProtKB:P06800] xref: UniProtKB:P06800 is_a: PR:000001006 ! receptor-type tyrosine-protein phosphatase C is_a: PR:000029032 ! Mus musculus protein intersection_of: PR:000001006 ! receptor-type tyrosine-protein phosphatase C intersection_of: RO:0002160 NCBITaxon:10090 ! only in taxon Mus musculus [Term] id: PR:P06876 name: transcriptional activator Myb (mouse) namespace: protein def: "A myb proto-oncogene protein that is encoded in the genome of mouse." [OMA:P06876, PRO:DNx] comment: Category=organism-gene. synonym: "mMYB" EXACT PRO-short-label [PRO:DNx] synonym: "Myb" RELATED Gene-based [UniProtKB:P06876] synonym: "proto-oncogene c-Myb (mouse)" EXACT [UniProtKB:P06876] xref: UniProtKB:P06876 is_a: PR:000010799 ! myb proto-oncogene protein is_a: PR:000029032 ! Mus musculus protein intersection_of: PR:000010799 ! myb proto-oncogene protein intersection_of: RO:0002160 NCBITaxon:10090 ! only in taxon Mus musculus [Term] id: PR:P06879 name: prolactin (mouse) namespace: protein def: "A prolactin that is encoded in the genome of mouse." [OMA:P06879, PRO:DNx] comment: Category=organism-gene. synonym: "mPRL" EXACT PRO-short-label [PRO:DNx] synonym: "Prl" RELATED Gene-based [UniProtKB:P06879] synonym: "PRL (mouse)" EXACT [UniProtKB:P06879] xref: UniProtKB:P06879 is_a: PR:000013246 ! prolactin is_a: PR:000029032 ! Mus musculus protein intersection_of: PR:000013246 ! prolactin intersection_of: RO:0002160 NCBITaxon:10090 ! only in taxon Mus musculus [Term] id: PR:P06881-1 name: calcitonin gene-related peptide 1 (human) namespace: protein def: "A calcitonin gene-related peptide 1 that is encoded in the genome of human." [PRO:DAN] comment: Category=organism-sequence. synonym: "hCALCA/iso:CGRP1" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:P06881-1 is_a: PR:000027226 ! calcitonin gene-related peptide 1 is_a: PR:000030026 ! CALCA gene translation product (human) intersection_of: PR:000027226 ! calcitonin gene-related peptide 1 intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:P07101 name: tyrosine 3-monooxygenase (human) namespace: protein def: "A tyrosine 3-monooxygenase that is encoded in the genome of human." [PRO:DNx, UniProtKB:P07101] comment: Category=organism-gene. synonym: "hTH" EXACT PRO-short-label [PRO:DNx] synonym: "TH" RELATED Gene-based [UniProtKB:P07101] synonym: "TYH" RELATED Gene-based [UniProtKB:P07101] synonym: "tyrosine 3-hydroxylase (human)" EXACT [UniProtKB:P07101] xref: Reactome:R-HSA-2980863 "PR:P07101 located_in GO:0005829" xref: UniProtKB:P07101 is_a: PR:000016301 ! tyrosine 3-monooxygenase is_a: PR:000029067 ! Homo sapiens protein intersection_of: PR:000016301 ! tyrosine 3-monooxygenase intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:P07204 name: thrombomodulin (human) namespace: protein def: "A thrombomodulin that is encoded in the genome of human." [PRO:WCB, UniProtKB:P07204] comment: Category=organism-gene. synonym: "CD141 (human)" EXACT [UniProtKB:P07204] synonym: "fetomodulin (human)" EXACT [UniProtKB:P07204] synonym: "hTHBD" EXACT PRO-short-label [PRO:DNx] synonym: "THBD" RELATED Gene-based [UniProtKB:P07204] synonym: "THRM" RELATED Gene-based [UniProtKB:P07204] synonym: "TM (human)" EXACT [UniProtKB:P07204] xref: UniProtKB:P07204 is_a: PR:000002105 ! thrombomodulin is_a: PR:000029067 ! Homo sapiens protein intersection_of: PR:000002105 ! thrombomodulin intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:P07333 name: macrophage colony-stimulating factor 1 receptor (human) namespace: protein def: "A macrophage colony-stimulating factor 1 receptor that is encoded in the genome of human." [PRO:WCB, UniProtKB:P07333] comment: Category=organism-gene. synonym: "CD115 (human)" EXACT [UniProtKB:P07333] synonym: "CSF-1 receptor (human)" EXACT [UniProtKB:P07333] synonym: "CSF-1-R (human)" EXACT [UniProtKB:P07333] synonym: "CSF-1R (human)" EXACT [UniProtKB:P07333] synonym: "CSF1R" RELATED Gene-based [UniProtKB:P07333] synonym: "FMS" RELATED Gene-based [UniProtKB:P07333] synonym: "hCSF1R" EXACT PRO-short-label [PRO:DNx] synonym: "M-CSF-R (human)" EXACT [UniProtKB:P07333] synonym: "proto-oncogene c-Fms (human)" EXACT [UniProtKB:P07333] xref: DTO:03100090 xref: UniProtKB:P07333 is_a: PR:000002062 ! macrophage colony-stimulating factor 1 receptor is_a: PR:000029067 ! Homo sapiens protein intersection_of: PR:000002062 ! macrophage colony-stimulating factor 1 receptor intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:P07359 name: platelet glycoprotein Ib alpha chain (human) namespace: protein def: "A platelet glycoprotein Ib alpha chain that is encoded in the genome of human." [PRO:WCB, UniProtKB:P07359] comment: Category=organism-gene. synonym: "antigen CD42b-alpha (human)" EXACT [UniProtKB:P07359] synonym: "CD42b (human)" EXACT [UniProtKB:P07359] synonym: "glycoprotein Ibalpha (human)" EXACT [UniProtKB:P07359] synonym: "GP-Ib alpha (human)" EXACT [UniProtKB:P07359] synonym: "GP1BA" RELATED Gene-based [UniProtKB:P07359] synonym: "GPIb-alpha (human)" EXACT [UniProtKB:P07359] synonym: "GPIbA (human)" EXACT [UniProtKB:P07359] synonym: "hGP1BA" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:P07359 is_a: PR:000001907 ! platelet glycoprotein Ib alpha chain is_a: PR:000029067 ! Homo sapiens protein intersection_of: PR:000001907 ! platelet glycoprotein Ib alpha chain intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:P07451 name: carbonic anhydrase 3 (human) namespace: protein def: "A carbonic anhydrase 3 that is encoded in the genome of human." [PRO:DNx, UniProtKB:P07451] comment: Category=organism-gene. synonym: "CA-III (human)" EXACT [UniProtKB:P07451] synonym: "CA3" RELATED Gene-based [UniProtKB:P07451] synonym: "carbonate dehydratase III (human)" EXACT [UniProtKB:P07451] synonym: "carbonic anhydrase III (human)" EXACT [UniProtKB:P07451] synonym: "hCA3" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:P07451 is_a: PR:000004919 ! carbonic anhydrase 3 is_a: PR:000029067 ! Homo sapiens protein intersection_of: PR:000004919 ! carbonic anhydrase 3 intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:P07766 name: T-cell surface glycoprotein CD3 epsilon chain (human) namespace: protein def: "A CD3 epsilon that is encoded in the genome of human." [PRO:CNA, UniProtKB:P07766] comment: Category=organism-gene. synonym: "CD3E" RELATED Gene-based [UniProtKB:P07766] synonym: "CD3e (human)" EXACT [UniProtKB:P07766] synonym: "hCD3E" EXACT PRO-short-label [PRO:DNx] synonym: "T-cell surface antigen T3/Leu-4 epsilon chain (human)" EXACT [UniProtKB:P07766] synonym: "T3E" RELATED Gene-based [UniProtKB:P07766] xref: UniProtKB:P07766 is_a: PR:000001020 ! CD3 epsilon is_a: PR:000029067 ! Homo sapiens protein intersection_of: PR:000001020 ! CD3 epsilon intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:P07949 name: proto-oncogene tyrosine-protein kinase receptor Ret (human) namespace: protein def: "A proto-oncogene tyrosine-protein kinase receptor Ret that is encoded in the genome of human." [PRO:DNx, UniProtKB:P07949] comment: Category=organism-gene. synonym: "cadherin family member 12 (human)" EXACT [UniProtKB:P07949] synonym: "CDHF12" RELATED Gene-based [UniProtKB:P07949] synonym: "CDHR16" RELATED Gene-based [UniProtKB:P07949] synonym: "hRET" EXACT PRO-short-label [PRO:DNx] synonym: "proto-oncogene c-Ret (human)" EXACT [UniProtKB:P07949] synonym: "PTC" RELATED Gene-based [UniProtKB:P07949] synonym: "RET" RELATED Gene-based [UniProtKB:P07949] xref: DTO:03100446 xref: UniProtKB:P07949 is_a: PR:000013895 ! proto-oncogene tyrosine-protein kinase receptor Ret is_a: PR:000029067 ! Homo sapiens protein intersection_of: PR:000013895 ! proto-oncogene tyrosine-protein kinase receptor Ret intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:P08071 name: lactotransferrin (mouse) namespace: protein def: "A lactotransferrin that is encoded in the genome of mouse." [OMA:P08071, PRO:DNx] comment: Category=organism-gene. synonym: "lactoferrin (mouse)" EXACT [UniProtKB:P08071] synonym: "Ltf" RELATED Gene-based [UniProtKB:P08071] synonym: "mLTF" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:P08071 is_a: PR:000009978 ! lactotransferrin is_a: PR:000029032 ! Mus musculus protein intersection_of: PR:000009978 ! lactotransferrin intersection_of: RO:0002160 NCBITaxon:10090 ! only in taxon Mus musculus [Term] id: PR:P08101 name: low affinity immunoglobulin gamma Fc region receptor II (mouse) namespace: protein def: "A low affinity immunoglobulin gamma Fc region receptor II that is encoded in the genome of mouse." [PRO:CNA, UniProtKB:P08101] comment: Category=organism-gene. synonym: "CD32 (mouse)" EXACT [UniProtKB:P08101] synonym: "Fc gamma receptor IIB (mouse)" EXACT [UniProtKB:P08101] synonym: "Fc-gamma RII (mouse)" EXACT [UniProtKB:P08101] synonym: "Fc-gamma-RIIB (mouse)" EXACT [UniProtKB:P08101] synonym: "Fcgr2" RELATED Gene-based [UniProtKB:P08101] synonym: "Fcgr2b" RELATED Gene-based [UniProtKB:P08101] synonym: "FcRII (mouse)" EXACT [UniProtKB:P08101] synonym: "IgG Fc receptor II beta (mouse)" EXACT [UniProtKB:P08101] synonym: "Ly-17" RELATED Gene-based [UniProtKB:P08101] synonym: "lymphocyte antigen 17 (mouse)" EXACT [UniProtKB:P08101] synonym: "mFcgr2" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:P08101 is_a: PR:000001479 ! low affinity immunoglobulin gamma Fc region receptor II is_a: PR:000029032 ! Mus musculus protein intersection_of: PR:000001479 ! low affinity immunoglobulin gamma Fc region receptor II intersection_of: RO:0002160 NCBITaxon:10090 ! only in taxon Mus musculus [Term] id: PR:P08121 name: collagen alpha-1(III) chain (mouse) namespace: protein def: "A collagen alpha-1(III) chain that is encoded in the genome of mouse." [OMA:P08121, PRO:DNx] comment: Category=organism-gene. synonym: "Col3a1" RELATED Gene-based [UniProtKB:P08121] synonym: "mCOL3A1" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:P08121 is_a: PR:000003328 ! collagen alpha-1(III) chain is_a: PR:000029032 ! Mus musculus protein intersection_of: PR:000003328 ! collagen alpha-1(III) chain intersection_of: RO:0002160 NCBITaxon:10090 ! only in taxon Mus musculus [Term] id: PR:P08152 name: E3 SUMO-protein ligase EGR2 (mouse) namespace: protein def: "An early growth response protein 2 that is encoded in the genome of mouse." [OMA:P08152, PRO:DNx] comment: Category=organism-gene. synonym: "E3 SUMO-protein transferase ERG2 (mouse)" EXACT [UniProtKB:P08152] synonym: "early growth response protein 2 (mouse)" EXACT [UniProtKB:P08152] synonym: "Egr-2" RELATED Gene-based [UniProtKB:P08152] synonym: "EGR-2 (mouse)" EXACT [UniProtKB:P08152] synonym: "Egr2" RELATED Gene-based [UniProtKB:P08152] synonym: "Krox-20" RELATED Gene-based [UniProtKB:P08152] synonym: "mEGR2" EXACT PRO-short-label [PRO:DNx] synonym: "Zfp-25" RELATED Gene-based [UniProtKB:P08152] synonym: "zinc finger protein Krox-20 (mouse)" EXACT [UniProtKB:P08152] xref: UniProtKB:P08152 is_a: PR:000003469 ! early growth response protein 2 is_a: PR:000029032 ! Mus musculus protein intersection_of: PR:000003469 ! early growth response protein 2 intersection_of: RO:0002160 NCBITaxon:10090 ! only in taxon Mus musculus [Term] id: PR:P08473 name: neprilysin (human) namespace: protein def: "A neprilysin that is encoded in the genome of human." [PRO:WCB, UniProtKB:P08473] comment: Category=organism-gene. synonym: "atriopeptidase (human)" EXACT [UniProtKB:P08473] synonym: "CALLA (human)" EXACT [UniProtKB:P08473] synonym: "CD10 (human)" EXACT [UniProtKB:P08473] synonym: "common acute lymphocytic leukemia antigen (human)" EXACT [UniProtKB:P08473] synonym: "enkephalinase (human)" EXACT [UniProtKB:P08473] synonym: "EPN" RELATED Gene-based [UniProtKB:P08473] synonym: "hMME" EXACT PRO-short-label [PRO:DNx] synonym: "MME" RELATED Gene-based [UniProtKB:P08473] synonym: "NEP (human)" EXACT [UniProtKB:P08473] synonym: "neutral endopeptidase (human)" EXACT [UniProtKB:P08473] synonym: "neutral endopeptidase 24.11 (human)" EXACT [UniProtKB:P08473] synonym: "SFE (human)" EXACT [UniProtKB:P08473] synonym: "skin fibroblast elastase (human)" EXACT [UniProtKB:P08473] xref: UniProtKB:P08473 is_a: PR:000001898 ! neprilysin is_a: PR:000029067 ! Homo sapiens protein intersection_of: PR:000001898 ! neprilysin intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:P08508 name: low affinity immunoglobulin gamma Fc region receptor III (mouse) namespace: protein def: "A low affinity immunoglobulin gamma Fc region receptor III that is encoded in the genome of mouse." [PRO:CNA, UniProtKB:P08508] comment: Category=organism-gene. synonym: "CD16 (mouse)" EXACT [UniProtKB:P08508] synonym: "Fc-gamma RIII (mouse)" EXACT [UniProtKB:P08508] synonym: "Fcgr3" RELATED Gene-based [UniProtKB:P08508] synonym: "FcRIII (mouse)" EXACT [UniProtKB:P08508] synonym: "IgG Fc receptor III (mouse)" EXACT [UniProtKB:P08508] synonym: "mFcgr3" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:P08508 is_a: PR:000001483 ! low affinity immunoglobulin gamma Fc region receptor III is_a: PR:000029032 ! Mus musculus protein intersection_of: PR:000001483 ! low affinity immunoglobulin gamma Fc region receptor III intersection_of: RO:0002160 NCBITaxon:10090 ! only in taxon Mus musculus [Term] id: PR:P08514 name: integrin alpha-IIb (human) namespace: protein def: "An integrin alpha-IIb that is encoded in the genome of human." [PRO:DNx, UniProtKB:P08514] comment: Category=organism-gene. synonym: "CD41 (human)" EXACT [UniProtKB:P08514] synonym: "GP2B" RELATED Gene-based [UniProtKB:P08514] synonym: "GPalpha IIb (human)" EXACT [UniProtKB:P08514] synonym: "GPIIb (human)" EXACT [UniProtKB:P08514] synonym: "hITGA2B" EXACT PRO-short-label [PRO:DNx] synonym: "ITGA2B" RELATED Gene-based [UniProtKB:P08514] synonym: "ITGAB" RELATED Gene-based [UniProtKB:P08514] synonym: "platelet membrane glycoprotein IIb (human)" EXACT [UniProtKB:P08514] xref: UniProtKB:P08514 is_a: PR:000009127 ! integrin alpha-IIb is_a: PR:000029067 ! Homo sapiens protein intersection_of: PR:000009127 ! integrin alpha-IIb intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:P08571 name: monocyte differentiation antigen CD14 (human) namespace: protein def: "A CD14 molecule that is encoded in the genome of human." [PRO:WCB, UniProtKB:P08571] comment: Category=organism-gene. synonym: "CD14" RELATED Gene-based [UniProtKB:P08571] synonym: "hCD14" EXACT PRO-short-label [PRO:DNx] synonym: "My23 antigen (human)" EXACT [UniProtKB:P08571] synonym: "myeloid cell-specific leucine-rich glycoprotein (human)" EXACT [UniProtKB:P08571] xref: UniProtKB:P08571 is_a: PR:000001889 ! CD14 molecule is_a: PR:000029067 ! Homo sapiens protein intersection_of: PR:000001889 ! CD14 molecule intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:P08575 name: receptor-type tyrosine-protein phosphatase C (human) namespace: protein def: "A receptor-type tyrosine-protein phosphatase C that is encoded in the genome of human." [PRO:CNA, UniProtKB:P08575] comment: Category=organism-gene. synonym: "CD45" RELATED Gene-based [UniProtKB:P08575] synonym: "hPTPRC" EXACT PRO-short-label [PRO:DNx] synonym: "L-CA (human)" EXACT [UniProtKB:P08575] synonym: "leukocyte common antigen (human)" EXACT [UniProtKB:P08575] synonym: "PTPRC" RELATED Gene-based [UniProtKB:P08575] synonym: "T200 (human)" EXACT [UniProtKB:P08575] xref: UniProtKB:P08575 is_a: PR:000001006 ! receptor-type tyrosine-protein phosphatase C is_a: PR:000029067 ! Homo sapiens protein intersection_of: PR:000001006 ! receptor-type tyrosine-protein phosphatase C intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:P08575-3 name: receptor-type tyrosine-protein phosphatase C isoform CD45RABC (human) namespace: protein def: "A receptor-type tyrosine-protein phosphatase C isoform CD45RABC that is encoded in the genome of human." [PRO:DAN] comment: Category=organism-sequence. synonym: "hPTPRC/iso:CD45RABC" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:P08575-3 is_a: PR:000001014 ! receptor-type tyrosine-protein phosphatase C isoform CD45RABC is_a: PR:P08575 ! receptor-type tyrosine-protein phosphatase C (human) intersection_of: PR:000001014 ! receptor-type tyrosine-protein phosphatase C isoform CD45RABC intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:P08575-4 name: receptor-type tyrosine-protein phosphatase C isoform CD45RO (human) namespace: protein def: "A receptor-type tyrosine-protein phosphatase C isoform CD45RO that is encoded in the genome of human." [GOC:add, PRO:ADD, PRO:DAN] comment: Category=organism-sequence. synonym: "CD45RO (human)" EXACT [GOC:add, PRO:ADD] synonym: "hPTPRC/iso:CD45RO" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:P08575-4 is_a: PR:000001017 ! receptor-type tyrosine-protein phosphatase C isoform CD45RO is_a: PR:P08575 ! receptor-type tyrosine-protein phosphatase C (human) intersection_of: PR:000001017 ! receptor-type tyrosine-protein phosphatase C isoform CD45RO intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:P08575-8 name: receptor-type tyrosine-protein phosphatase C isoform CD45RA (human) namespace: protein def: "A receptor-type tyrosine-protein phosphatase C isoform CD45RA that is encoded in the genome of human." [GOC:add, PRO:ADD, PRO:DAN] comment: Category=organism-sequence. Requested by=CL. synonym: "CD45RA (human)" EXACT [] synonym: "hPTPRC/iso:CD45RA" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:P08575-8 is_a: PR:000001015 ! receptor-type tyrosine-protein phosphatase C isoform CD45RA is_a: PR:P08575 ! receptor-type tyrosine-protein phosphatase C (human) intersection_of: PR:000001015 ! receptor-type tyrosine-protein phosphatase C isoform CD45RA intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:P08670 name: vimentin (human) namespace: protein def: "A vimentin that is encoded in the genome of human." [PRO:DNx, UniProtKB:P08670] comment: Category=organism-gene. synonym: "hVIM" EXACT PRO-short-label [PRO:DNx] synonym: "VIM" RELATED Gene-based [UniProtKB:P08670] xref: Reactome:R-HSA-9646687 "PR:P08670 located_in GO:0005829" xref: Reactome:R-HSA-9657898 "PR:P08670 located_in GO:0005815" xref: Reactome:R-HSA-9659977 "PR:P08670 located_in GO:0043202" xref: Reactome:R-HSA-9660019 "PR:P08670 located_in GO:0031906" xref: UniProtKB:P08670 is_a: PR:000017298 ! vimentin is_a: PR:000029067 ! Homo sapiens protein intersection_of: PR:000017298 ! vimentin intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:P08920 name: T-cell surface antigen CD2 (mouse) namespace: protein def: "A CD2 molecule that is encoded in the genome of mouse." [OMA:P08920, PRO:DNx] comment: Category=organism-gene. synonym: "Cd2" RELATED Gene-based [UniProtKB:P08920] synonym: "CD2 (mouse)" EXACT [UniProtKB:P08920] synonym: "LFA-2 (mouse)" EXACT [UniProtKB:P08920] synonym: "LFA-3 receptor (mouse)" EXACT [UniProtKB:P08920] synonym: "Ly-37" RELATED Gene-based [UniProtKB:P08920] synonym: "lymphocyte antigen 37 (mouse)" EXACT [UniProtKB:P08920] synonym: "mCD2" EXACT PRO-short-label [PRO:DNx] synonym: "T-cell surface antigen T11/Leu-5 (mouse)" EXACT [UniProtKB:P08920] xref: UniProtKB:P08920 is_a: PR:000001083 ! CD2 molecule is_a: PR:000029032 ! Mus musculus protein intersection_of: PR:000001083 ! CD2 molecule intersection_of: RO:0002160 NCBITaxon:10090 ! only in taxon Mus musculus [Term] id: PR:P09038 name: fibroblast growth factor 2 (human) namespace: protein def: "A fibroblast growth factor 2 that is encoded in the genome of human." [PRO:DNx, UniProtKB:P09038] comment: Category=organism-gene. synonym: "basic fibroblast growth factor (human)" EXACT [UniProtKB:P09038] synonym: "bFGF (human)" EXACT [UniProtKB:P09038] synonym: "FGF-2 (human)" EXACT [UniProtKB:P09038] synonym: "FGF2" RELATED Gene-based [UniProtKB:P09038] synonym: "FGFB" RELATED Gene-based [UniProtKB:P09038] synonym: "HBGF-2 (human)" EXACT [UniProtKB:P09038] synonym: "heparin-binding growth factor 2 (human)" EXACT [UniProtKB:P09038] synonym: "hFGF2" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:P09038 is_a: PR:000007489 ! fibroblast growth factor 2 is_a: PR:000029067 ! Homo sapiens protein intersection_of: PR:000007489 ! fibroblast growth factor 2 intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:P09172 name: dopamine beta-hydroxylase (human) namespace: protein def: "A dopamine beta-hydroxylase that is encoded in the genome of human." [PRO:DNx, UniProtKB:P09172] comment: Category=organism-gene. synonym: "DBH" RELATED Gene-based [UniProtKB:P09172] synonym: "dopamine beta-monooxygenase (human)" EXACT [UniProtKB:P09172] synonym: "hDBH" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:P09172 is_a: PR:000006294 ! dopamine beta-hydroxylase is_a: PR:000029067 ! Homo sapiens protein intersection_of: PR:000006294 ! dopamine beta-hydroxylase intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:P09240 name: cholecystokinin (mouse) namespace: protein def: "A cholecystokinin that is encoded in the genome of mouse." [OMA:P09240, PRO:DNx] comment: Category=organism-gene. synonym: "Cck" RELATED Gene-based [UniProtKB:P09240] synonym: "CCK (mouse)" EXACT [UniProtKB:P09240] synonym: "mCCK" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:P09240 is_a: PR:000005110 ! cholecystokinin is_a: PR:000029032 ! Mus musculus protein intersection_of: PR:000005110 ! cholecystokinin intersection_of: RO:0002160 NCBITaxon:10090 ! only in taxon Mus musculus [Term] id: PR:P09326 name: CD48 antigen (human) namespace: protein def: "A CD48 molecule that is encoded in the genome of human." [PRO:WCB, UniProtKB:P09326] comment: Category=organism-gene. synonym: "B-lymphocyte activation marker BLAST-1 (human)" EXACT [UniProtKB:P09326] synonym: "BCM1" RELATED Gene-based [UniProtKB:P09326] synonym: "BCM1 surface antigen (human)" EXACT [UniProtKB:P09326] synonym: "BLAST1" RELATED Gene-based [UniProtKB:P09326] synonym: "CD48" RELATED Gene-based [UniProtKB:P09326] synonym: "hCD48" EXACT PRO-short-label [PRO:DNx] synonym: "leukocyte antigen MEM-102 (human)" EXACT [UniProtKB:P09326] synonym: "signaling lymphocytic activation molecule 2 (human)" EXACT [UniProtKB:P09326] synonym: "SLAM family member 2 (human)" EXACT [UniProtKB:P09326] synonym: "SLAMF2 (human)" EXACT [UniProtKB:P09326] synonym: "TCT.1 (human)" EXACT [UniProtKB:P09326] xref: UniProtKB:P09326 is_a: PR:000001308 ! CD48 molecule is_a: PR:000029067 ! Homo sapiens protein intersection_of: PR:000001308 ! CD48 molecule intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:P09382 name: galectin-1 (human) namespace: protein def: "A galectin-1 that is encoded in the genome of human." [PRO:DNx, UniProtKB:P09382] comment: Category=organism-gene. synonym: "14 kDa laminin-binding protein (human)" EXACT [UniProtKB:P09382] synonym: "14 kDa lectin (human)" EXACT [UniProtKB:P09382] synonym: "beta-galactoside-binding lectin L-14-I (human)" EXACT [UniProtKB:P09382] synonym: "gal-1 (human)" EXACT [UniProtKB:P09382] synonym: "galaptin (human)" EXACT [UniProtKB:P09382] synonym: "HBL (human)" EXACT [UniProtKB:P09382] synonym: "HLBP14 (human)" EXACT [UniProtKB:P09382] synonym: "hLGALS1" EXACT PRO-short-label [PRO:DNx] synonym: "HPL (human)" EXACT [UniProtKB:P09382] synonym: "lactose-binding lectin 1 (human)" EXACT [UniProtKB:P09382] synonym: "lectin galactoside-binding soluble 1 (human)" EXACT [UniProtKB:P09382] synonym: "LGALS1" RELATED Gene-based [UniProtKB:P09382] synonym: "putative MAPK-activating protein PM12 (human)" EXACT [UniProtKB:P09382] synonym: "S-Lac lectin 1 (human)" EXACT [UniProtKB:P09382] xref: UniProtKB:P09382 is_a: PR:000009766 ! galectin-1 is_a: PR:000029067 ! Homo sapiens protein intersection_of: PR:000009766 ! galectin-1 intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:P09564 name: T-cell antigen CD7 (human) namespace: protein def: "A CD7 molecule that is encoded in the genome of human." [PRO:WCB, UniProtKB:P09564] comment: Category=organism-gene. synonym: "CD7" RELATED Gene-based [UniProtKB:P09564] synonym: "GP40 (human)" EXACT [UniProtKB:P09564] synonym: "hCD7" EXACT PRO-short-label [PRO:DNx] synonym: "T-cell leukemia antigen (human)" EXACT [UniProtKB:P09564] synonym: "T-cell surface antigen Leu-9 (human)" EXACT [UniProtKB:P09564] synonym: "TP41 (human)" EXACT [UniProtKB:P09564] xref: UniProtKB:P09564 is_a: PR:000001836 ! CD7 molecule is_a: PR:000029067 ! Homo sapiens protein intersection_of: PR:000001836 ! CD7 molecule intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:P09581 name: macrophage colony-stimulating factor 1 receptor (mouse) namespace: protein def: "A macrophage colony-stimulating factor 1 receptor that is encoded in the genome of mouse." [OMA:P09581, PRO:DNx] comment: Category=organism-gene. synonym: "CD115 (mouse)" EXACT [UniProtKB:P09581] synonym: "CSF-1 receptor (mouse)" EXACT [UniProtKB:P09581] synonym: "CSF-1-R (mouse)" EXACT [UniProtKB:P09581] synonym: "CSF-1R (mouse)" EXACT [UniProtKB:P09581] synonym: "Csf1r" RELATED Gene-based [UniProtKB:P09581] synonym: "Csfmr" RELATED Gene-based [UniProtKB:P09581] synonym: "Fms" RELATED Gene-based [UniProtKB:P09581] synonym: "M-CSF-R (mouse)" EXACT [UniProtKB:P09581] synonym: "mCSF1R" EXACT PRO-short-label [PRO:DNx] synonym: "proto-oncogene c-Fms (mouse)" EXACT [UniProtKB:P09581] xref: UniProtKB:P09581 is_a: PR:000002062 ! macrophage colony-stimulating factor 1 receptor is_a: PR:000029032 ! Mus musculus protein intersection_of: PR:000002062 ! macrophage colony-stimulating factor 1 receptor intersection_of: RO:0002160 NCBITaxon:10090 ! only in taxon Mus musculus [Term] id: PR:P09793 name: cytotoxic T-lymphocyte protein 4 (mouse) namespace: protein def: "A cytotoxic T-lymphocyte protein 4 that is encoded in the genome of mouse." [OMA:P09793, PRO:DNx] comment: Category=organism-gene. synonym: "Cd152" RELATED Gene-based [UniProtKB:P09793] synonym: "CD152 (mouse)" EXACT [UniProtKB:P09793] synonym: "CTLA-4 (mouse)" EXACT [UniProtKB:P09793] synonym: "Ctla4" RELATED Gene-based [UniProtKB:P09793] synonym: "cytotoxic T-lymphocyte-associated antigen 4 (mouse)" EXACT [UniProtKB:P09793] synonym: "mCTLA4" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:P09793 is_a: PR:000001852 ! cytotoxic T-lymphocyte protein 4 is_a: PR:000029032 ! Mus musculus protein intersection_of: PR:000001852 ! cytotoxic T-lymphocyte protein 4 intersection_of: RO:0002160 NCBITaxon:10090 ! only in taxon Mus musculus [Term] id: PR:P09803 name: cadherin-1 (mouse) namespace: protein def: "A cadherin-1 that is encoded in the genome of mouse." [PRO:WCB] comment: Category=organism-gene. synonym: "ARC-1 (mouse)" EXACT [UniProtKB:P09803] synonym: "CD324 (mouse)" EXACT [UniProtKB:P09803] synonym: "Cdh1" RELATED Gene-based [UniProtKB:P09803] synonym: "E-cadherin (mouse)" EXACT [UniProtKB:P09803] synonym: "epithelial cadherin (mouse)" EXACT [UniProtKB:P09803] synonym: "mCDH1" EXACT PRO-short-label [PRO:DNx] synonym: "uvomorulin (mouse)" EXACT [UniProtKB:P09803] xref: UniProtKB:P09803 is_a: PR:000001447 ! cadherin-1 is_a: PR:000029032 ! Mus musculus protein intersection_of: PR:000001447 ! cadherin-1 intersection_of: RO:0002160 NCBITaxon:10090 ! only in taxon Mus musculus [Term] id: PR:P09838 name: DNA nucleotidylexotransferase (mouse) namespace: protein def: "A DNA nucleotidylexotransferase that is encoded in the genome of mouse." [OMA:P09838, PRO:DNx] comment: Category=organism-gene. synonym: "Dntt" RELATED Gene-based [UniProtKB:P09838] synonym: "mDNTT" EXACT PRO-short-label [PRO:DNx] synonym: "Tdt" RELATED Gene-based [UniProtKB:P09838] synonym: "TDT (mouse)" EXACT [UniProtKB:P09838] synonym: "terminal addition enzyme (mouse)" EXACT [UniProtKB:P09838] synonym: "terminal deoxynucleotidyltransferase (mouse)" EXACT [UniProtKB:P09838] synonym: "terminal transferase (mouse)" RELATED [UniProtKB:P09838] xref: UniProtKB:P09838 is_a: PR:000006611 ! DNA nucleotidylexotransferase is_a: PR:000029032 ! Mus musculus protein intersection_of: PR:000006611 ! DNA nucleotidylexotransferase intersection_of: RO:0002160 NCBITaxon:10090 ! only in taxon Mus musculus [Term] id: PR:P0CW03 name: lymphocyte antigen 6C2 (mouse) namespace: protein def: "A lymphocyte antigen 6C2 that is encoded in the genome of mouse." [PRO:CNA, UniProtKB:P0CW03] comment: Category=organism-gene. synonym: "Ly-6C2 (mouse)" EXACT [UniProtKB:P0CW03] synonym: "Ly6c" RELATED Gene-based [UniProtKB:P0CW03] synonym: "Ly6c2" RELATED Gene-based [UniProtKB:P0CW03] synonym: "mLy6c2" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:P0CW03 is_a: PR:000002980 ! lymphocyte antigen 6C2 is_a: PR:000029032 ! Mus musculus protein intersection_of: PR:000002980 ! lymphocyte antigen 6C2 intersection_of: RO:0002160 NCBITaxon:10090 ! only in taxon Mus musculus [Term] id: PR:P0DN77 name: medium-wave-sensitive opsin 2 (human) namespace: protein def: "A medium-wave-sensitive opsin (human) that is a translation product of the OPN1MW2 gene in human." [PRO:DAN, UniProtKB:P0DN77] comment: Category=organism-gene. Note: The proteins encoded by OPN1MW (PR:P04001), OPN1MW2 (this class), and OPN1MW3 (PR:P0DN78) are identical. synonym: "GOP (human)" BROAD [UniProtKB:P0DN77] synonym: "green cone photoreceptor pigment (human)" BROAD [UniProtKB:P0DN77] synonym: "green-sensitive opsin (human)" BROAD [UniProtKB:P0DN77] synonym: "hOPN1MW2" EXACT PRO-short-label [PRO:DNx] synonym: "OPN1MW2" RELATED Gene-based [UniProtKB:P0DN77] synonym: "opsin 1 cone pigments medium-wave-sensitive 2 (human)" EXACT [UniProtKB:P0DN77] xref: UniProtKB:P0DN77 is_a: PR:000050522 ! medium-wave-sensitive opsin (human) [Term] id: PR:P0DN78 name: medium-wave-sensitive opsin 3 (human) namespace: protein def: "A medium-wave-sensitive opsin (human) that is a translation product of the OPN1MW3 gene in human." [PRO:DAN, UniProtKB:P0DN78] comment: Category=organism-gene. Note: The proteins encoded by OPN1MW (PR:P04001), OPN1MW2 (PR:P0DN77), and OPN1MW3 (this class) are identical. synonym: "GOP (human)" BROAD [UniProtKB:P0DN78] synonym: "green cone photoreceptor pigment (human)" BROAD [UniProtKB:P0DN78] synonym: "green-sensitive opsin (human)" BROAD [UniProtKB:P0DN78] synonym: "hOPN1MW3" EXACT PRO-short-label [PRO:DNx] synonym: "OPN1MW3" RELATED Gene-based [UniProtKB:P0DN78] synonym: "opsin 1 cone pigments medium-wave-sensitive 3 (human)" EXACT [UniProtKB:P0DN78] xref: UniProtKB:P0DN78 is_a: PR:000050522 ! medium-wave-sensitive opsin (human) [Term] id: PR:P10144 name: granzyme B (human) namespace: protein def: "A granzyme B that is encoded in the genome of human." [PRO:CNA, UniProtKB:P10144] comment: Category=organism-gene. synonym: "C11 (human)" EXACT [UniProtKB:P10144] synonym: "cathepsin G-like 1 (human)" EXACT [UniProtKB:P10144] synonym: "CGL1" RELATED Gene-based [UniProtKB:P10144] synonym: "CSPB" RELATED Gene-based [UniProtKB:P10144] synonym: "CTLA-1 (human)" EXACT [UniProtKB:P10144] synonym: "CTLA1" RELATED Gene-based [UniProtKB:P10144] synonym: "CTSGL1 (human)" EXACT [UniProtKB:P10144] synonym: "cytotoxic T-lymphocyte proteinase 2 (human)" EXACT [UniProtKB:P10144] synonym: "fragmentin-2 (human)" EXACT [UniProtKB:P10144] synonym: "granzyme-2 (human)" EXACT [UniProtKB:P10144] synonym: "GRB" RELATED Gene-based [UniProtKB:P10144] synonym: "GZMB" RELATED Gene-based [UniProtKB:P10144] synonym: "hGZMB" EXACT PRO-short-label [PRO:DNx] synonym: "HLP (human)" BROAD [UniProtKB:P10144] synonym: "human lymphocyte protein" EXACT [UniProtKB:P10144] synonym: "lymphocyte protease (human)" EXACT [UniProtKB:P10144] synonym: "SECT (human)" EXACT [UniProtKB:P10144] synonym: "T-cell serine protease 1-3E (human)" EXACT [UniProtKB:P10144] xref: UniProtKB:P10144 is_a: PR:000003499 ! granzyme B is_a: PR:000029067 ! Homo sapiens protein intersection_of: PR:000003499 ! granzyme B intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:P10147 name: C-C motif chemokine 3 (human) namespace: protein def: "A C-C motif chemokine 3 that is encoded in the genome of human." [PRO:WCB, UniProtKB:P10147] comment: Category=organism-gene. synonym: "CCL3" RELATED Gene-based [UniProtKB:P10147] synonym: "G0/G1 switch regulatory protein 19-1 (human)" EXACT [UniProtKB:P10147] synonym: "G0S19-1" RELATED Gene-based [UniProtKB:P10147] synonym: "hCCL3" EXACT PRO-short-label [PRO:DNx] synonym: "macrophage inflammatory protein 1-alpha (human)" EXACT [UniProtKB:P10147] synonym: "MIP-1-alpha (human)" EXACT [UniProtKB:P10147] synonym: "MIP1A" RELATED Gene-based [UniProtKB:P10147] synonym: "PAT 464.1 (human)" EXACT [UniProtKB:P10147] synonym: "SCYA3" RELATED Gene-based [UniProtKB:P10147] synonym: "SIS-beta (human)" EXACT [UniProtKB:P10147] synonym: "small-inducible cytokine A3 (human)" EXACT [UniProtKB:P10147] synonym: "tonsillar lymphocyte LD78 alpha protein (human)" EXACT [UniProtKB:P10147] xref: UniProtKB:P10147 is_a: PR:000002123 ! C-C motif chemokine 3 is_a: PR:000029067 ! Homo sapiens protein intersection_of: PR:000002123 ! C-C motif chemokine 3 intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:P10153 name: non-secretory ribonuclease (human) namespace: protein def: "A non-secretory ribonuclease that is encoded in the genome of human." [PRO:DNx, UniProtKB:P10153] comment: Category=organism-gene. synonym: "EDN" RELATED Gene-based [UniProtKB:P10153] synonym: "eosinophil-derived neurotoxin (human)" EXACT [UniProtKB:P10153] synonym: "hRNASE2" EXACT PRO-short-label [PRO:DNx] synonym: "ribonuclease 2 (human)" EXACT [UniProtKB:P10153] synonym: "ribonuclease US (human)" EXACT [UniProtKB:P10153] synonym: "RNase 2 (human)" EXACT [UniProtKB:P10153] synonym: "RNase UpI-2 (human)" EXACT [UniProtKB:P10153] synonym: "RNASE2" RELATED Gene-based [UniProtKB:P10153] synonym: "RNS2" RELATED Gene-based [UniProtKB:P10153] xref: UniProtKB:P10153 is_a: PR:000014046 ! non-secretory ribonuclease is_a: PR:000029067 ! Homo sapiens protein intersection_of: PR:000014046 ! non-secretory ribonuclease intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:P10242 name: transcriptional activator Myb (human) namespace: protein def: "A myb proto-oncogene protein that is encoded in the genome of human." [PRO:DNx, UniProtKB:P10242] comment: Category=organism-gene. synonym: "hMYB" EXACT PRO-short-label [PRO:DNx] synonym: "MYB" RELATED Gene-based [UniProtKB:P10242] synonym: "proto-oncogene c-Myb (human)" EXACT [UniProtKB:P10242] xref: Reactome:R-HSA-992697 "PR:P10242 located_in GO:0005654" xref: UniProtKB:P10242 is_a: PR:000010799 ! myb proto-oncogene protein is_a: PR:000029067 ! Homo sapiens protein intersection_of: PR:000010799 ! myb proto-oncogene protein intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:P10300 name: T-cell surface glycoprotein CD8 beta chain (mouse) namespace: protein def: "A T-cell surface glycoprotein CD8 beta chain that is encoded in the genome of mouse." [PRO:CNA] comment: Category=organism-gene. synonym: "Cd8b" RELATED Gene-based [UniProtKB:P10300] synonym: "CD8b (mouse)" EXACT [UniProtKB:P10300] synonym: "Cd8b1" RELATED Gene-based [UniProtKB:P10300] synonym: "Ly-3" RELATED Gene-based [UniProtKB:P10300] synonym: "lymphocyte antigen 3 (mouse)" EXACT [UniProtKB:P10300] synonym: "Lyt-3" RELATED Gene-based [UniProtKB:P10300] synonym: "Lyt3" RELATED Gene-based [UniProtKB:P10300] synonym: "mCD8B" EXACT PRO-short-label [PRO:DNx] synonym: "T-cell membrane glycoprotein Ly-3 (mouse)" EXACT [UniProtKB:P10300] synonym: "T-cell surface glycoprotein Lyt-3 (mouse)" EXACT [UniProtKB:P10300] xref: UniProtKB:P10300 is_a: PR:000001085 ! T-cell surface glycoprotein CD8 beta chain is_a: PR:000029032 ! Mus musculus protein intersection_of: PR:000001085 ! T-cell surface glycoprotein CD8 beta chain intersection_of: RO:0002160 NCBITaxon:10090 ! only in taxon Mus musculus [Term] id: PR:P10721 name: mast/stem cell growth factor receptor Kit (human) namespace: protein def: "A mast/stem cell growth factor receptor that is encoded in the genome of human." [PRO:WCB, UniProtKB:P10721] comment: Category=organism-gene. synonym: "CD117 (human)" EXACT [UniProtKB:P10721] synonym: "hKIT" EXACT PRO-short-label [PRO:DNx] synonym: "KIT" RELATED Gene-based [UniProtKB:P10721] synonym: "p145 c-kit (human)" EXACT [UniProtKB:P10721] synonym: "PBT (human)" EXACT [UniProtKB:P10721] synonym: "piebald trait protein (human)" EXACT [UniProtKB:P10721] synonym: "proto-oncogene c-Kit (human)" EXACT [UniProtKB:P10721] synonym: "SCFR" RELATED Gene-based [UniProtKB:P10721] synonym: "tyrosine-protein kinase Kit (human)" EXACT [UniProtKB:P10721] synonym: "v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog (human)" EXACT [UniProtKB:P10721] xref: DTO:03100231 xref: UniProtKB:P10721 is_a: PR:000002065 ! mast/stem cell growth factor receptor is_a: PR:000029067 ! Homo sapiens protein intersection_of: PR:000002065 ! mast/stem cell growth factor receptor intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:P10747 name: T-cell-specific surface glycoprotein CD28 (human) namespace: protein def: "A T-cell-specific surface glycoprotein CD28 that is encoded in the genome of human." [PRO:WCB, UniProtKB:P10747] comment: Category=organism-gene. synonym: "CD28" RELATED Gene-based [UniProtKB:P10747] synonym: "hCD28" EXACT PRO-short-label [PRO:DNx] synonym: "TP44 (human)" EXACT [UniProtKB:P10747] xref: UniProtKB:P10747 is_a: PR:000001841 ! T-cell-specific surface glycoprotein CD28 is_a: PR:000029067 ! Homo sapiens protein intersection_of: PR:000001841 ! T-cell-specific surface glycoprotein CD28 intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:P10810 name: monocyte differentiation antigen CD14 (mouse) namespace: protein def: "A CD14 molecule that is encoded in the genome of mouse." [OMA:P10810, PRO:WCB] comment: Category=organism-gene. synonym: "Cd14" RELATED Gene-based [UniProtKB:P10810] synonym: "CD14 (mouse)" EXACT [UniProtKB:P10810] synonym: "mCD14" EXACT PRO-short-label [PRO:DNx] synonym: "myeloid cell-specific leucine-rich glycoprotein (mouse)" EXACT [UniProtKB:P10810] xref: UniProtKB:P10810 is_a: PR:000001889 ! CD14 molecule is_a: PR:000029032 ! Mus musculus protein intersection_of: PR:000001889 ! CD14 molecule intersection_of: RO:0002160 NCBITaxon:10090 ! only in taxon Mus musculus [Term] id: PR:P10820 name: perforin-1 (mouse) namespace: protein def: "A perforin-1 that is encoded in the genome of mouse." [OMA:P10820, PRO:DNx] comment: Category=organism-gene. synonym: "cytolysin (mouse)" EXACT [UniProtKB:P10820] synonym: "lymphocyte pore-forming protein (mouse)" EXACT [UniProtKB:P10820] synonym: "mPRF1" EXACT PRO-short-label [PRO:DNx] synonym: "P1 (mouse)" EXACT [UniProtKB:P10820] synonym: "Pfp" RELATED Gene-based [UniProtKB:P10820] synonym: "Prf1" RELATED Gene-based [UniProtKB:P10820] xref: UniProtKB:P10820 is_a: PR:000003466 ! perforin-1 is_a: PR:000029032 ! Mus musculus protein intersection_of: PR:000003466 ! perforin-1 intersection_of: RO:0002160 NCBITaxon:10090 ! only in taxon Mus musculus [Term] id: PR:P10855 name: C-C motif chemokine 3 (mouse) namespace: protein def: "A C-C motif chemokine 3 that is encoded in the genome of mouse." [PRO:WCB] comment: Category=organism-gene. synonym: "Ccl3" RELATED Gene-based [UniProtKB:P10855] synonym: "heparin-binding chemotaxis protein (mouse)" EXACT [UniProtKB:P10855] synonym: "L2G25B (mouse)" EXACT [UniProtKB:P10855] synonym: "macrophage inflammatory protein 1-alpha (mouse)" EXACT [UniProtKB:P10855] synonym: "mCCL3" EXACT PRO-short-label [PRO:DNx] synonym: "MIP-1-alpha (mouse)" EXACT [UniProtKB:P10855] synonym: "Mip1a" RELATED Gene-based [UniProtKB:P10855] synonym: "Scya3" RELATED Gene-based [UniProtKB:P10855] synonym: "SIS-alpha (mouse)" EXACT [UniProtKB:P10855] synonym: "small-inducible cytokine A3 (mouse)" EXACT [UniProtKB:P10855] synonym: "TY-5 (mouse)" EXACT [UniProtKB:P10855] xref: UniProtKB:P10855 is_a: PR:000002123 ! C-C motif chemokine 3 is_a: PR:000029032 ! Mus musculus protein intersection_of: PR:000002123 ! C-C motif chemokine 3 intersection_of: RO:0002160 NCBITaxon:10090 ! only in taxon Mus musculus [Term] id: PR:P10966 name: T-cell surface glycoprotein CD8 beta chain (human) namespace: protein def: "A T-cell surface glycoprotein CD8 beta chain that is encoded in the genome of human." [PRO:CNA, UniProtKB:P10966] comment: Category=organism-gene. synonym: "CD8B" RELATED Gene-based [UniProtKB:P10966] synonym: "CD8b (human)" EXACT [UniProtKB:P10966] synonym: "CD8B1" RELATED Gene-based [UniProtKB:P10966] synonym: "hCD8B" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:P10966 is_a: PR:000001085 ! T-cell surface glycoprotein CD8 beta chain is_a: PR:000029067 ! Homo sapiens protein intersection_of: PR:000001085 ! T-cell surface glycoprotein CD8 beta chain intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:P10966-1 name: T-cell surface glycoprotein CD8 beta chain isoform 1 (human) namespace: protein def: "A T-cell surface glycoprotein CD8 beta chain isoform 1 that is encoded in the genome of human." [PRO:DAN] comment: Category=organism-sequence. synonym: "hCD8B/iso:1" EXACT PRO-short-label [PRO:DNx] synonym: "T-cell surface glycoprotein CD8 beta chain isoform M-1 (human)" EXACT [UniProtKB:P10966] synonym: "T-cell surface glycoprotein CD8 beta chain isoform Mbeta1 (human)" EXACT [UniProtKB:P10966] xref: UniProtKB:P10966-1 is_a: PR:000025405 ! T-cell surface glycoprotein CD8 beta chain isoform 1 is_a: PR:P10966 ! T-cell surface glycoprotein CD8 beta chain (human) intersection_of: PR:000025405 ! T-cell surface glycoprotein CD8 beta chain isoform 1 intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:P11087 name: collagen alpha-1(I) chain (mouse) namespace: protein def: "A collagen alpha-1(I) chain that is encoded in the genome of mouse." [OMA:P11087, PRO:DNx] comment: Category=organism-gene. synonym: "alpha-1 type I collagen (mouse)" EXACT [UniProtKB:P11087] synonym: "Col1a1" RELATED Gene-based [UniProtKB:P11087] synonym: "Cola1" RELATED Gene-based [UniProtKB:P11087] synonym: "mCOL1A1" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:P11087 is_a: PR:000003264 ! collagen alpha-1(I) chain is_a: PR:000029032 ! Mus musculus protein intersection_of: PR:000003264 ! collagen alpha-1(I) chain intersection_of: RO:0002160 NCBITaxon:10090 ! only in taxon Mus musculus [Term] id: PR:P11161 name: E3 SUMO-protein ligase EGR2 (human) namespace: protein def: "An early growth response protein 2 that is encoded in the genome of human." [PRO:CNA, UniProtKB:P11161] comment: Category=organism-gene. synonym: "AT591 (human)" EXACT [UniProtKB:P11161] synonym: "E3 SUMO-protein transferase ERG2 (human)" EXACT [UniProtKB:P11161] synonym: "early growth response protein 2 (human)" EXACT [UniProtKB:P11161] synonym: "EGR-2 (human)" EXACT [UniProtKB:P11161] synonym: "EGR2" RELATED Gene-based [UniProtKB:P11161] synonym: "hEGR2" EXACT PRO-short-label [PRO:DNx] synonym: "KROX20" RELATED Gene-based [UniProtKB:P11161] synonym: "zinc finger protein Krox-20 (human)" EXACT [UniProtKB:P11161] xref: Reactome:R-HSA-977385 "PR:P11161 located_in GO:0005654" xref: UniProtKB:P11161 is_a: PR:000003469 ! early growth response protein 2 is_a: PR:000029067 ! Homo sapiens protein intersection_of: PR:000003469 ! early growth response protein 2 intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:P11215 name: integrin alpha-M (human) namespace: protein def: "An integrin alpha-M that is encoded in the genome of human." [PRO:DNx, UniProtKB:P11215] comment: Category=organism-gene. synonym: "CD11 antigen-like family member B (human)" EXACT [UniProtKB:P11215] synonym: "CD11B" RELATED Gene-based [UniProtKB:P11215] synonym: "cell surface glycoprotein MAC-1 subunit alpha (human)" EXACT [UniProtKB:P11215] synonym: "CR-3 alpha chain (human)" EXACT [UniProtKB:P11215] synonym: "CR3A" RELATED Gene-based [UniProtKB:P11215] synonym: "hITGAM" EXACT PRO-short-label [PRO:DNx] synonym: "ITGAM" RELATED Gene-based [UniProtKB:P11215] synonym: "leukocyte adhesion receptor MO1 (human)" EXACT [UniProtKB:P11215] synonym: "neutrophil adherence receptor (human)" EXACT [UniProtKB:P11215] xref: UniProtKB:P11215 is_a: PR:000001012 ! integrin alpha-M is_a: PR:000029067 ! Homo sapiens protein intersection_of: PR:000001012 ! integrin alpha-M intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:P11247 name: myeloperoxidase (mouse) namespace: protein def: "A myeloperoxidase that is encoded in the genome of mouse." [OMA:P11247, PRO:DNx] comment: Category=organism-gene. synonym: "mMPO" EXACT PRO-short-label [PRO:DNx] synonym: "Mpo" RELATED Gene-based [UniProtKB:P11247] synonym: "MPO (mouse)" EXACT [UniProtKB:P11247] xref: UniProtKB:P11247 is_a: PR:000010543 ! myeloperoxidase is_a: PR:000029032 ! Mus musculus protein intersection_of: PR:000010543 ! myeloperoxidase intersection_of: RO:0002160 NCBITaxon:10090 ! only in taxon Mus musculus [Term] id: PR:P11609 name: antigen-presenting glycoprotein CD1d1 (mouse) namespace: protein def: "An antigen-presenting glycoprotein CD1d that is encoded in the genome of mouse." [PRO:WCB] comment: Category=organism-gene. synonym: "Cd1.1" RELATED Gene-based [UniProtKB:P11609] synonym: "CD1d.1 (mouse)" EXACT [UniProtKB:P11609] synonym: "Cd1d1" RELATED Gene-based [UniProtKB:P11609] synonym: "mCD1D" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:P11609 is_a: PR:000002028 ! antigen-presenting glycoprotein CD1d is_a: PR:000029032 ! Mus musculus protein intersection_of: PR:000002028 ! antigen-presenting glycoprotein CD1d intersection_of: RO:0002160 NCBITaxon:10090 ! only in taxon Mus musculus [Term] id: PR:P11672 name: neutrophil gelatinase-associated lipocalin (mouse) namespace: protein def: "A neutrophil gelatinase-associated lipocalin that is encoded in the genome of mouse." [OMA:P11672, PRO:DNx] comment: Category=organism-gene. synonym: "24p3 (mouse)" EXACT [UniProtKB:P11672] synonym: "Lcn2" RELATED Gene-based [UniProtKB:P11672] synonym: "lipocalin-2 (mouse)" EXACT [UniProtKB:P11672] synonym: "mLCN2" EXACT PRO-short-label [PRO:DNx] synonym: "NGAL (mouse)" EXACT [UniProtKB:P11672] synonym: "oncogene 24p3 (mouse)" EXACT [UniProtKB:P11672] synonym: "p25 (mouse)" BROAD [UniProtKB:P11672] synonym: "siderocalin LCN2 (mouse)" EXACT [UniProtKB:P11672] synonym: "SV-40-induced 24p3 protein (mouse)" EXACT [UniProtKB:P11672] xref: UniProtKB:P11672 is_a: PR:000009725 ! neutrophil gelatinase-associated lipocalin is_a: PR:000029032 ! Mus musculus protein intersection_of: PR:000009725 ! neutrophil gelatinase-associated lipocalin intersection_of: RO:0002160 NCBITaxon:10090 ! only in taxon Mus musculus [Term] id: PR:P11678 name: eosinophil peroxidase (human) namespace: protein def: "An eosinophil peroxidase that is encoded in the genome of human." [PRO:DNx, UniProtKB:P11678] comment: Category=organism-gene. synonym: "EPER" RELATED Gene-based [UniProtKB:P11678] synonym: "EPO" RELATED Gene-based [UniProtKB:P11678] synonym: "EPP" RELATED Gene-based [UniProtKB:P11678] synonym: "EPX" RELATED Gene-based [UniProtKB:P11678] synonym: "hEPX" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:P11678 is_a: PR:000007152 ! eosinophil peroxidase is_a: PR:000029067 ! Homo sapiens protein intersection_of: PR:000007152 ! eosinophil peroxidase intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:P11684 name: uteroglobin (human) namespace: protein def: "A uteroglobin that is encoded in the genome of human." [PRO:DNx, UniProtKB:P11684] comment: Category=organism-gene. synonym: "CC10" RELATED Gene-based [UniProtKB:P11684] synonym: "CCPBP (human)" EXACT [UniProtKB:P11684] synonym: "CCSP" RELATED Gene-based [UniProtKB:P11684] synonym: "Club cell phospholipid-binding protein (human)" EXACT [UniProtKB:P11684] synonym: "Club cells 10 kDa secretory protein (human)" EXACT [UniProtKB:P11684] synonym: "hSCGB1A1" EXACT PRO-short-label [PRO:DNx] synonym: "SCGB1A1" RELATED Gene-based [UniProtKB:P11684] synonym: "secretoglobin family 1A member 1 (human)" EXACT [UniProtKB:P11684] synonym: "UGB" RELATED Gene-based [UniProtKB:P11684] synonym: "UP-1 (human)" EXACT [UniProtKB:P11684] synonym: "UP1 (human)" EXACT [UniProtKB:P11684] synonym: "urinary protein 1 (human)" EXACT [UniProtKB:P11684] synonym: "urine protein 1 (human)" EXACT [UniProtKB:P11684] xref: UniProtKB:P11684 is_a: PR:000014505 ! uteroglobin is_a: PR:000029067 ! Homo sapiens protein intersection_of: PR:000014505 ! uteroglobin intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:P11836 name: B-lymphocyte antigen CD20 (human) namespace: protein def: "A membrane-spanning 4-domains subfamily A member 1 that is encoded in the genome of human." [PRO:WCB, UniProtKB:P11836] comment: Category=organism-gene. synonym: "B-lymphocyte surface antigen B1 (human)" EXACT [UniProtKB:P11836] synonym: "Bp35 (human)" EXACT [UniProtKB:P11836] synonym: "CD20" RELATED Gene-based [UniProtKB:P11836] synonym: "hMS4A1" EXACT PRO-short-label [PRO:DNx] synonym: "leukocyte surface antigen Leu-16 (human)" EXACT [UniProtKB:P11836] synonym: "membrane-spanning 4-domains subfamily A member 1 (human)" EXACT [UniProtKB:P11836] synonym: "MS4A1" RELATED Gene-based [UniProtKB:P11836] xref: UniProtKB:P11836 is_a: PR:000001289 ! membrane-spanning 4-domains subfamily A member 1 is_a: PR:000029067 ! Homo sapiens protein intersection_of: PR:000001289 ! membrane-spanning 4-domains subfamily A member 1 intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:P12018 name: immunoglobulin iota chain (human) namespace: protein def: "An immunoglobulin iota chain that is encoded in the genome of human." [PRO:WCB, UniProtKB:P12018] comment: Category=organism-gene. synonym: "CD179 antigen-like family member A (human)" EXACT [UniProtKB:P12018] synonym: "CD179a (human)" EXACT [UniProtKB:P12018] synonym: "hVPREB1" EXACT PRO-short-label [PRO:DNx] synonym: "protein VPreB1 (human)" EXACT [UniProtKB:P12018] synonym: "V(pre)B protein (human)" EXACT [UniProtKB:P12018] synonym: "VPREB" RELATED Gene-based [UniProtKB:P12018] synonym: "VpreB protein (human)" EXACT [UniProtKB:P12018] synonym: "VPREB1" RELATED Gene-based [UniProtKB:P12018] xref: UniProtKB:P12018 is_a: PR:000001858 ! immunoglobulin iota chain is_a: PR:000029067 ! Homo sapiens protein intersection_of: PR:000001858 ! immunoglobulin iota chain intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:P12036 name: neurofilament heavy polypeptide (human) namespace: protein def: "A neurofilament heavy polypeptide that is encoded in the genome of human." [PRO:DNx, UniProtKB:P12036] comment: Category=organism-gene. synonym: "200 kDa neurofilament protein (human)" EXACT [UniProtKB:P12036] synonym: "hNEFH" EXACT PRO-short-label [PRO:DNx] synonym: "KIAA0845" RELATED Gene-based [UniProtKB:P12036] synonym: "NEFH" RELATED Gene-based [UniProtKB:P12036] synonym: "neurofilament triplet H protein (human)" EXACT [UniProtKB:P12036] synonym: "NF-H (human)" EXACT [UniProtKB:P12036] synonym: "NFH" RELATED Gene-based [UniProtKB:P12036] xref: UniProtKB:P12036 is_a: PR:000011118 ! neurofilament heavy polypeptide is_a: PR:000029067 ! Homo sapiens protein intersection_of: PR:000011118 ! neurofilament heavy polypeptide intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:P12107 name: collagen alpha-1(XI) chain (human) namespace: protein def: "A collagen alpha-1(XI) chain that is encoded in the genome of human." [PRO:DNx, UniProtKB:P12107] comment: Category=organism-gene. synonym: "COL11A1" RELATED Gene-based [UniProtKB:P12107] synonym: "COLL6" RELATED Gene-based [UniProtKB:P12107] synonym: "hCOL11A1" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:P12107 is_a: PR:000005694 ! collagen alpha-1(XI) chain is_a: PR:000029067 ! Homo sapiens protein intersection_of: PR:000005694 ! collagen alpha-1(XI) chain intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:P12109 name: collagen alpha-1(VI) chain (human) namespace: protein def: "A collagen alpha-1(VI) chain that is encoded in the genome of human." [PRO:CNA, UniProtKB:P12109] comment: Category=organism-gene. synonym: "COL6A1" RELATED Gene-based [UniProtKB:P12109] synonym: "hCOL6A1" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:P12109 is_a: PR:000003353 ! collagen alpha-1(VI) chain is_a: PR:000029067 ! Homo sapiens protein intersection_of: PR:000003353 ! collagen alpha-1(VI) chain intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:P12272 name: parathyroid hormone-related protein (human) namespace: protein def: "A parathyroid hormone-related protein that is encoded in the genome of human." [PRO:DNx, UniProtKB:P12272] comment: Category=organism-gene. synonym: "hPTHLH" EXACT PRO-short-label [PRO:DNx] synonym: "parathyroid hormone-like protein (human)" EXACT [UniProtKB:P12272] synonym: "PLP (human)" BROAD [UniProtKB:P12272] synonym: "PTH-rP (human)" EXACT [UniProtKB:P12272] synonym: "PTHLH" RELATED Gene-based [UniProtKB:P12272] synonym: "PTHRP" RELATED Gene-based [UniProtKB:P12272] xref: UniProtKB:P12272 is_a: PR:000013433 ! parathyroid hormone-related protein is_a: PR:000029067 ! Homo sapiens protein intersection_of: PR:000013433 ! parathyroid hormone-related protein intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:P12314 name: high affinity immunoglobulin gamma Fc receptor I (human) namespace: protein def: "A high affinity immunoglobulin gamma Fc receptor I that is encoded in the genome of human." [PRO:CNA, UniProtKB:P12314] comment: Category=organism-gene. synonym: "CD64 (human)" EXACT [UniProtKB:P12314] synonym: "Fc-gamma RI (human)" EXACT [UniProtKB:P12314] synonym: "Fc-gamma RIA (human)" EXACT [UniProtKB:P12314] synonym: "FCG1" RELATED Gene-based [UniProtKB:P12314] synonym: "FcgammaRIa (human)" EXACT [UniProtKB:P12314] synonym: "FCGR1" RELATED Gene-based [UniProtKB:P12314] synonym: "FCGR1A" RELATED Gene-based [UniProtKB:P12314] synonym: "FcRI (human)" EXACT [UniProtKB:P12314] synonym: "hFCGR1A" EXACT PRO-short-label [PRO:DNx] synonym: "IGFR1" RELATED Gene-based [UniProtKB:P12314] synonym: "IgG Fc receptor I (human)" EXACT [UniProtKB:P12314] xref: UniProtKB:P12314 is_a: PR:000001465 ! high affinity immunoglobulin gamma Fc receptor I is_a: PR:000029067 ! Homo sapiens protein intersection_of: PR:000001465 ! high affinity immunoglobulin gamma Fc receptor I intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:P12319 name: high affinity immunoglobulin epsilon receptor subunit alpha (human) namespace: protein def: "A high affinity immunoglobulin epsilon receptor subunit alpha that is encoded in the genome of human." [PRO:DNx, UniProtKB:P12319] comment: Category=organism-gene. synonym: "Fc-epsilon RI-alpha (human)" EXACT [UniProtKB:P12319] synonym: "FCE1A" RELATED Gene-based [UniProtKB:P12319] synonym: "FCER1A" RELATED Gene-based [UniProtKB:P12319] synonym: "FcERI (human)" BROAD [UniProtKB:P12319] synonym: "hFCER1A" EXACT PRO-short-label [PRO:DNx] synonym: "IgE Fc receptor subunit alpha (human)" EXACT [UniProtKB:P12319] xref: UniProtKB:P12319 is_a: PR:000007431 ! high affinity immunoglobulin epsilon receptor subunit alpha is_a: PR:000029067 ! Homo sapiens protein intersection_of: PR:000007431 ! high affinity immunoglobulin epsilon receptor subunit alpha intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:P12724 name: eosinophil cationic protein (human) namespace: protein def: "An eosinophil cationic protein that is encoded in the genome of human." [PRO:DNx, UniProtKB:P12724] comment: Category=organism-gene. synonym: "ECP" RELATED Gene-based [UniProtKB:P12724] synonym: "hRNASE3" EXACT PRO-short-label [PRO:DNx] synonym: "ribonuclease 3 (human)" RELATED [UniProtKB:P12724] synonym: "RNase 3 (human)" EXACT [UniProtKB:P12724] synonym: "RNASE3" RELATED Gene-based [UniProtKB:P12724] synonym: "RNS3" RELATED Gene-based [UniProtKB:P12724] xref: UniProtKB:P12724 is_a: PR:000014047 ! eosinophil cationic protein is_a: PR:000029067 ! Homo sapiens protein intersection_of: PR:000014047 ! eosinophil cationic protein intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:P12830 name: cadherin-1 (human) namespace: protein def: "A cadherin-1 that is encoded in the genome of human." [PRO:WCB, UniProtKB:P12830] comment: Category=organism-gene. synonym: "CAM 120/80 (human)" EXACT [UniProtKB:P12830] synonym: "CD324 (human)" EXACT [UniProtKB:P12830] synonym: "CDH1" RELATED Gene-based [UniProtKB:P12830] synonym: "CDHE" RELATED Gene-based [UniProtKB:P12830] synonym: "E-cadherin (human)" EXACT [UniProtKB:P12830] synonym: "epithelial cadherin (human)" EXACT [UniProtKB:P12830] synonym: "hCDH1" EXACT PRO-short-label [PRO:DNx] synonym: "UVO" RELATED Gene-based [UniProtKB:P12830] synonym: "uvomorulin (human)" EXACT [UniProtKB:P12830] xref: UniProtKB:P12830 is_a: PR:000001447 ! cadherin-1 is_a: PR:000029067 ! Homo sapiens protein intersection_of: PR:000001447 ! cadherin-1 intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:P13379 name: T-cell surface glycoprotein CD5 (mouse) namespace: protein def: "A T-cell surface glycoprotein CD5 that is encoded in the genome of mouse." [OMA:P13379, PRO:DNx] comment: Category=organism-gene. synonym: "Cd5" RELATED Gene-based [UniProtKB:P13379] synonym: "CD5 (mouse)" EXACT [UniProtKB:P13379] synonym: "Ly-1" RELATED Gene-based [UniProtKB:P13379] synonym: "lymphocyte antigen 1 (mouse)" EXACT [UniProtKB:P13379] synonym: "Lyt-1 (mouse)" EXACT [UniProtKB:P13379] synonym: "mCD5" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:P13379 is_a: PR:000001839 ! T-cell surface glycoprotein CD5 is_a: PR:000029032 ! Mus musculus protein intersection_of: PR:000001839 ! T-cell surface glycoprotein CD5 intersection_of: RO:0002160 NCBITaxon:10090 ! only in taxon Mus musculus [Term] id: PR:P13591 name: neural cell adhesion molecule 1 (human) namespace: protein def: "A neural cell adhesion molecule 1 that is encoded in the genome of human." [PRO:CNA, UniProtKB:P13591] comment: Category=organism-gene. synonym: "CD56 (human)" EXACT [UniProtKB:P13591] synonym: "hNCAM1" EXACT PRO-short-label [PRO:DNx] synonym: "N-CAM-1 (human)" EXACT [UniProtKB:P13591] synonym: "NCAM" RELATED Gene-based [UniProtKB:P13591] synonym: "NCAM-1 (human)" EXACT [UniProtKB:P13591] synonym: "NCAM1" RELATED Gene-based [UniProtKB:P13591] xref: UniProtKB:P13591 is_a: PR:000001024 ! neural cell adhesion molecule 1 is_a: PR:000029067 ! Homo sapiens protein intersection_of: PR:000001024 ! neural cell adhesion molecule 1 intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:P13595 name: neural cell adhesion molecule 1 (mouse) namespace: protein def: "A neural cell adhesion molecule 1 that is encoded in the genome of mouse." [OMA:P13595, PRO:DNx] comment: Category=organism-gene. synonym: "CD56 (mouse)" EXACT [UniProtKB:P13595] synonym: "mNCAM1" EXACT PRO-short-label [PRO:DNx] synonym: "N-CAM-1 (mouse)" EXACT [UniProtKB:P13595] synonym: "Ncam" RELATED Gene-based [UniProtKB:P13595] synonym: "NCAM-1 (mouse)" EXACT [UniProtKB:P13595] synonym: "Ncam1" RELATED Gene-based [UniProtKB:P13595] xref: UniProtKB:P13595 is_a: PR:000001024 ! neural cell adhesion molecule 1 is_a: PR:000029032 ! Mus musculus protein intersection_of: PR:000001024 ! neural cell adhesion molecule 1 intersection_of: RO:0002160 NCBITaxon:10090 ! only in taxon Mus musculus [Term] id: PR:P13612 name: integrin alpha-4 (human) namespace: protein def: "An integrin alpha-4 that is encoded in the genome of human." [PRO:DNx, UniProtKB:P13612] comment: Category=organism-gene. synonym: "CD49 antigen-like family member D (human)" EXACT [UniProtKB:P13612] synonym: "CD49D" RELATED Gene-based [UniProtKB:P13612] synonym: "hITGA4" EXACT PRO-short-label [PRO:DNx] synonym: "integrin alpha-IV (human)" EXACT [UniProtKB:P13612] synonym: "ITGA4" RELATED Gene-based [UniProtKB:P13612] synonym: "VLA-4 subunit alpha (human)" EXACT [UniProtKB:P13612] xref: UniProtKB:P13612 is_a: PR:000009129 ! integrin alpha-4 is_a: PR:000029067 ! Homo sapiens protein intersection_of: PR:000009129 ! integrin alpha-4 intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:P13686 name: tartrate-resistant acid phosphatase type 5 (human) namespace: protein def: "A tartrate-resistant acid phosphatase type 5 that is encoded in the genome of human." [PRO:WCB, UniProtKB:P13686] comment: Category=organism-gene. synonym: "ACP5" RELATED Gene-based [UniProtKB:P13686] synonym: "hACP5" EXACT PRO-short-label [PRO:DNx] synonym: "tartrate-resistant acid ATPase (human)" EXACT [UniProtKB:P13686] synonym: "TR-AP (human)" EXACT [UniProtKB:P13686] synonym: "TrATPase (human)" EXACT [UniProtKB:P13686] synonym: "type 5 acid phosphatase (human)" EXACT [UniProtKB:P13686] xref: UniProtKB:P13686 is_a: PR:000001937 ! tartrate-resistant acid phosphatase type 5 is_a: PR:000029067 ! Homo sapiens protein intersection_of: PR:000001937 ! tartrate-resistant acid phosphatase type 5 intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:P13727 name: bone marrow proteoglycan (human) namespace: protein def: "A bone marrow proteoglycan that is encoded in the genome of human." [PRO:DNx, UniProtKB:P13727] comment: Category=organism-gene. synonym: "BMPG (human)" EXACT [UniProtKB:P13727] synonym: "hPRG2" EXACT PRO-short-label [PRO:DNx] synonym: "MBP" RELATED Gene-based [UniProtKB:P13727] synonym: "PRG2" RELATED Gene-based [UniProtKB:P13727] synonym: "proteoglycan 2 (human)" EXACT [UniProtKB:P13727] xref: UniProtKB:P13727 is_a: PR:000013206 ! bone marrow proteoglycan is_a: PR:000029067 ! Homo sapiens protein intersection_of: PR:000013206 ! bone marrow proteoglycan intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:P13727-1 name: bone marrow proteoglycan isoform 1 (human) namespace: protein def: "A bone marrow proteoglycan isoform 1 that is encoded in the genome of human." [PRO:CNA] comment: Category=organism-sequence. synonym: "hPRG2/iso:1" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:P13727-1 is_a: PR:000022003 ! bone marrow proteoglycan isoform 1 is_a: PR:P13727 ! bone marrow proteoglycan (human) intersection_of: PR:000022003 ! bone marrow proteoglycan isoform 1 intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:P14136 name: glial fibrillary acidic protein (human) namespace: protein def: "A glial fibrillary acidic protein that is encoded in the genome of human." [PRO:DNx, UniProtKB:P14136] comment: Category=organism-gene. synonym: "GFAP" RELATED Gene-based [UniProtKB:P14136] synonym: "hGFAP" EXACT PRO-short-label [PRO:DNx] xref: Reactome:R-HSA-1253311 "PR:P14136 located_in GO:0005829" xref: Reactome:R-HSA-9625195 "PR:P14136 located_in GO:0005765" xref: UniProtKB:P14136 is_a: PR:000007939 ! glial fibrillary acidic protein is_a: PR:000029067 ! Homo sapiens protein intersection_of: PR:000007939 ! glial fibrillary acidic protein intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:P14151 name: L-selectin (human) namespace: protein def: "An L-selectin that is encoded in the genome of human." [PRO:JAN, UniProtKB:P14151] comment: Category=organism-gene. synonym: "CD62 antigen-like family member L (human)" EXACT [UniProtKB:P14151] synonym: "CD62L (human)" EXACT [UniProtKB:P14151] synonym: "gp90-MEL (human)" EXACT [UniProtKB:P14151] synonym: "hSELL" EXACT PRO-short-label [PRO:DNx] synonym: "LAM-1 (human)" EXACT [UniProtKB:P14151] synonym: "LECAM1 (human)" EXACT [UniProtKB:P14151] synonym: "leukocyte adhesion molecule 1 (human)" EXACT [UniProtKB:P14151] synonym: "leukocyte surface antigen Leu-8 (human)" EXACT [UniProtKB:P14151] synonym: "leukocyte-endothelial cell adhesion molecule 1 (human)" EXACT [UniProtKB:P14151] synonym: "LNHR" RELATED Gene-based [UniProtKB:P14151] synonym: "LYAM1" RELATED Gene-based [UniProtKB:P14151] synonym: "lymph node homing receptor (human)" EXACT [UniProtKB:P14151] synonym: "SELL" RELATED Gene-based [UniProtKB:P14151] synonym: "TQ1 (human)" EXACT [UniProtKB:P14151] xref: UniProtKB:P14151 is_a: PR:000001318 ! L-selectin is_a: PR:000029067 ! Homo sapiens protein intersection_of: PR:000001318 ! L-selectin intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:P14211 name: calreticulin (mouse) namespace: protein def: "A calreticulin that is encoded in the genome of mouse." [OMA:P14211, PRO:DNx] comment: Category=organism-gene. synonym: "Calr" RELATED Gene-based [UniProtKB:P14211] synonym: "calregulin (mouse)" EXACT [UniProtKB:P14211] synonym: "CRP55 (mouse)" EXACT [UniProtKB:P14211] synonym: "endoplasmic reticulum resident protein 60 (mouse)" EXACT [UniProtKB:P14211] synonym: "ERp60 (mouse)" EXACT [UniProtKB:P14211] synonym: "HACBP (mouse)" EXACT [UniProtKB:P14211] synonym: "mCALR" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:P14211 is_a: PR:000004984 ! calreticulin is_a: PR:000029032 ! Mus musculus protein intersection_of: PR:000004984 ! calreticulin intersection_of: RO:0002160 NCBITaxon:10090 ! only in taxon Mus musculus [Term] id: PR:P14222 name: perforin-1 (human) namespace: protein def: "A perforin-1 that is encoded in the genome of human." [PRO:CNA, UniProtKB:P14222] comment: Category=organism-gene. synonym: "cytolysin (human)" EXACT [UniProtKB:P14222] synonym: "hPRF1" EXACT PRO-short-label [PRO:DNx] synonym: "lymphocyte pore-forming protein (human)" EXACT [UniProtKB:P14222] synonym: "P1 (human)" BROAD [UniProtKB:P14222] synonym: "PFP" RELATED Gene-based [UniProtKB:P14222] synonym: "PRF1" RELATED Gene-based [UniProtKB:P14222] xref: UniProtKB:P14222 is_a: PR:000003466 ! perforin-1 is_a: PR:000029067 ! Homo sapiens protein intersection_of: PR:000003466 ! perforin-1 intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:P14416 name: D(2) dopamine receptor (human) namespace: protein def: "A D(2) dopamine receptor that is encoded in the genome of human." [PRO:WCB, UniProtKB:P14416] comment: Category=organism-gene. synonym: "dopamine D2 receptor (human)" EXACT [UniProtKB:P14416] synonym: "DRD2" RELATED Gene-based [UniProtKB:P14416] synonym: "hDRD2" EXACT PRO-short-label [PRO:DNx] xref: DTO:02100082 xref: Reactome:R-HSA-390816 "PR:P14416 located_in GO:0005886" xref: UniProtKB:P14416 is_a: PR:000001177 ! D(2) dopamine receptor is_a: PR:000029067 ! Homo sapiens protein intersection_of: PR:000001177 ! D(2) dopamine receptor intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:P14719 name: interleukin-1 receptor-like 1 (mouse) namespace: protein def: "An interleukin-1 receptor-like 1 that is encoded in the genome of mouse." [OMA:P14719, PRO:DNx] comment: Category=organism-gene. synonym: "Il1rl1" RELATED Gene-based [UniProtKB:P14719] synonym: "interleukin-33 receptor alpha chain (mouse)" EXACT [UniProtKB:P14719] synonym: "Ly84" RELATED Gene-based [UniProtKB:P14719] synonym: "lymphocyte antigen 84 (mouse)" EXACT [UniProtKB:P14719] synonym: "mIL1RL1" EXACT PRO-short-label [PRO:DNx] synonym: "protein ST2 (mouse)" EXACT [UniProtKB:P14719] synonym: "protein T1 (mouse)" EXACT [UniProtKB:P14719] synonym: "St2" RELATED Gene-based [UniProtKB:P14719] synonym: "Ste2" RELATED Gene-based [UniProtKB:P14719] xref: UniProtKB:P14719 is_a: PR:000008994 ! interleukin-1 receptor-like 1 is_a: PR:000029032 ! Mus musculus protein intersection_of: PR:000008994 ! interleukin-1 receptor-like 1 intersection_of: RO:0002160 NCBITaxon:10090 ! only in taxon Mus musculus [Term] id: PR:P14784 name: interleukin-2 receptor subunit beta (human) namespace: protein def: "An interleukin-2 receptor subunit beta that is encoded in the genome of human." [PRO:CNA, UniProtKB:P14784] comment: Category=organism-gene. synonym: "CD122 (human)" EXACT [UniProtKB:P14784] synonym: "high affinity IL-2 receptor subunit beta (human)" EXACT [UniProtKB:P14784] synonym: "hIL2RB" EXACT PRO-short-label [PRO:DNx] synonym: "IL-2 receptor subunit beta (human)" EXACT [UniProtKB:P14784] synonym: "IL-2R subunit beta (human)" EXACT [UniProtKB:P14784] synonym: "IL-2RB (human)" EXACT [UniProtKB:P14784] synonym: "IL15RB" RELATED Gene-based [UniProtKB:P14784] synonym: "IL2RB" RELATED Gene-based [UniProtKB:P14784] synonym: "interleukin-15 receptor subunit beta (human)" EXACT [UniProtKB:P14784] synonym: "p70-75 (human)" EXACT [UniProtKB:P14784] synonym: "p75 (human)" BROAD [UniProtKB:P14784] xref: UniProtKB:P14784 is_a: PR:000001381 ! interleukin-2 receptor subunit beta is_a: PR:000029067 ! Homo sapiens protein intersection_of: PR:000001381 ! interleukin-2 receptor subunit beta intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:P15144 name: aminopeptidase N (human) namespace: protein def: "An aminopeptidase N that is encoded in the genome of human." [PRO:WCB, UniProtKB:P15144] comment: Category=organism-gene. synonym: "alanyl aminopeptidase (human)" EXACT [UniProtKB:P15144] synonym: "aminopeptidase M (human)" EXACT [UniProtKB:P15144] synonym: "ANPEP" RELATED Gene-based [UniProtKB:P15144] synonym: "AP-M (human)" EXACT [UniProtKB:P15144] synonym: "AP-N (human)" EXACT [UniProtKB:P15144] synonym: "APN" RELATED Gene-based [UniProtKB:P15144] synonym: "CD13" RELATED Gene-based [UniProtKB:P15144] synonym: "gp150 (human)" EXACT [UniProtKB:P15144] synonym: "hANPEP" EXACT PRO-short-label [PRO:DNx] synonym: "hAPN" EXACT [UniProtKB:P15144] synonym: "microsomal aminopeptidase (human)" EXACT [UniProtKB:P15144] synonym: "myeloid plasma membrane glycoprotein CD13 (human)" EXACT [UniProtKB:P15144] synonym: "PEPN" RELATED Gene-based [UniProtKB:P15144] xref: UniProtKB:P15144 is_a: PR:000002031 ! aminopeptidase N is_a: PR:000029067 ! Homo sapiens protein intersection_of: PR:000002031 ! aminopeptidase N intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:P15306 name: thrombomodulin (mouse) namespace: protein def: "A thrombomodulin that is encoded in the genome of mouse." [OMA:P15306, PRO:DNx] comment: Category=organism-gene. synonym: "CD141 (mouse)" EXACT [UniProtKB:P15306] synonym: "fetomodulin (mouse)" EXACT [UniProtKB:P15306] synonym: "mTHBD" EXACT PRO-short-label [PRO:DNx] synonym: "Thbd" RELATED Gene-based [UniProtKB:P15306] synonym: "TM (mouse)" EXACT [UniProtKB:P15306] xref: UniProtKB:P15306 is_a: PR:000002105 ! thrombomodulin is_a: PR:000029032 ! Mus musculus protein intersection_of: PR:000002105 ! thrombomodulin intersection_of: RO:0002160 NCBITaxon:10090 ! only in taxon Mus musculus [Term] id: PR:P15331 name: peripherin (mouse) namespace: protein def: "A peripherin that is encoded in the genome of mouse." [OMA:P15331, PRO:DNx] comment: Category=organism-gene. synonym: "mPRPH" EXACT PRO-short-label [PRO:DNx] synonym: "Prph" RELATED Gene-based [UniProtKB:P15331] synonym: "Prph1" RELATED Gene-based [UniProtKB:P15331] xref: UniProtKB:P15331 is_a: PR:000013289 ! peripherin is_a: PR:000029032 ! Mus musculus protein intersection_of: PR:000013289 ! peripherin intersection_of: RO:0002160 NCBITaxon:10090 ! only in taxon Mus musculus [Term] id: PR:P15379 name: CD44 antigen (mouse) namespace: protein def: "A CD44 molecule that is encoded in the genome of mouse." [OMA:P15379, PRO:WCB] comment: Category=organism-gene. synonym: "Cd44" RELATED Gene-based [UniProtKB:P15379] synonym: "CD44 (mouse)" EXACT [UniProtKB:P15379] synonym: "ECMR-III (mouse)" EXACT [UniProtKB:P15379] synonym: "extracellular matrix receptor III (mouse)" EXACT [UniProtKB:P15379] synonym: "GP90 lymphocyte homing/adhesion receptor (mouse)" EXACT [UniProtKB:P15379] synonym: "hermes antigen (mouse)" EXACT [UniProtKB:P15379] synonym: "HUTCH-I (mouse)" EXACT [UniProtKB:P15379] synonym: "hyaluronate receptor (mouse)" EXACT [UniProtKB:P15379] synonym: "Ly-24" RELATED Gene-based [UniProtKB:P15379] synonym: "lymphocyte antigen 24 (mouse)" EXACT [UniProtKB:P15379] synonym: "mCD44" EXACT PRO-short-label [PRO:DNx] synonym: "PGP-1 (mouse)" EXACT [UniProtKB:P15379] synonym: "PGP-I (mouse)" EXACT [UniProtKB:P15379] synonym: "phagocytic glycoprotein 1 (mouse)" EXACT [UniProtKB:P15379] synonym: "phagocytic glycoprotein I (mouse)" EXACT [UniProtKB:P15379] xref: UniProtKB:P15379 is_a: PR:000001307 ! CD44 molecule is_a: PR:000029032 ! Mus musculus protein intersection_of: PR:000001307 ! CD44 molecule intersection_of: RO:0002160 NCBITaxon:10090 ! only in taxon Mus musculus [Term] id: PR:P15391 name: B-lymphocyte antigen CD19 (human) namespace: protein def: "A CD19 molecule that is encoded in the genome of human." [] comment: Category=organism-gene. synonym: "B-lymphocyte surface antigen B4 (human)" EXACT [UniProtKB:P15391] synonym: "CD19" RELATED Gene-based [UniProtKB:P15391] synonym: "differentiation antigen CD19 (human)" EXACT [UniProtKB:P15391] synonym: "hCD19" EXACT PRO-short-label [PRO:DNx] synonym: "T-cell surface antigen Leu-12 (human)" EXACT [UniProtKB:P15391] xref: UniProtKB:P15391 is_a: PR:000001002 ! CD19 molecule is_a: PR:000029067 ! Homo sapiens protein intersection_of: PR:000001002 ! CD19 molecule intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:P15655 name: fibroblast growth factor 2 (mouse) namespace: protein def: "A fibroblast growth factor 2 that is encoded in the genome of mouse." [OMA:P15655, PRO:DNx] comment: Category=organism-gene. synonym: "basic fibroblast growth factor (mouse)" EXACT [UniProtKB:P15655] synonym: "bFGF (mouse)" EXACT [UniProtKB:P15655] synonym: "Fgf-2" RELATED Gene-based [UniProtKB:P15655] synonym: "FGF-2 (mouse)" EXACT [UniProtKB:P15655] synonym: "Fgf2" RELATED Gene-based [UniProtKB:P15655] synonym: "HBGF-2 (mouse)" EXACT [UniProtKB:P15655] synonym: "heparin-binding growth factor 2 (mouse)" EXACT [UniProtKB:P15655] synonym: "mFGF2" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:P15655 is_a: PR:000007489 ! fibroblast growth factor 2 is_a: PR:000029032 ! Mus musculus protein intersection_of: PR:000007489 ! fibroblast growth factor 2 intersection_of: RO:0002160 NCBITaxon:10090 ! only in taxon Mus musculus [Term] id: PR:P15702 name: leukosialin (mouse) namespace: protein def: "A leukosialin that is encoded in the genome of mouse." [OMA:P15702, PRO:DNx] comment: Category=organism-gene. synonym: "B-cell differentiation antigen LP-3 (mouse)" EXACT [UniProtKB:P15702] synonym: "CD43 (mouse)" EXACT [UniProtKB:P15702] synonym: "leukocyte sialoglycoprotein (mouse)" EXACT [UniProtKB:P15702] synonym: "Ly-48 (mouse)" EXACT [UniProtKB:P15702] synonym: "lymphocyte antigen 48 (mouse)" EXACT [UniProtKB:P15702] synonym: "mSPN" EXACT PRO-short-label [PRO:DNx] synonym: "sialophorin (mouse)" EXACT [UniProtKB:P15702] synonym: "Spn" RELATED Gene-based [UniProtKB:P15702] xref: UniProtKB:P15702 is_a: PR:000001879 ! leukosialin is_a: PR:000029032 ! Mus musculus protein intersection_of: PR:000001879 ! leukosialin intersection_of: RO:0002160 NCBITaxon:10090 ! only in taxon Mus musculus [Term] id: PR:P15813 name: antigen-presenting glycoprotein CD1d (human) namespace: protein def: "An antigen-presenting glycoprotein CD1d that is encoded in the genome of human." [PRO:WCB, UniProtKB:P15813] comment: Category=organism-gene. synonym: "CD1D" RELATED Gene-based [UniProtKB:P15813] synonym: "CD1d (human)" EXACT [UniProtKB:P15813] synonym: "hCD1D" EXACT PRO-short-label [PRO:DNx] synonym: "human CD1d chain" EXACT [MRO:0000891] synonym: "R3G1 (human)" EXACT [UniProtKB:P15813] xref: MRO:0000891 xref: UniProtKB:P15813 is_a: PR:000002028 ! antigen-presenting glycoprotein CD1d is_a: PR:000036947 ! T-cell surface glycoprotein CD1 (human) intersection_of: PR:000002028 ! antigen-presenting glycoprotein CD1d intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:P15814 name: immunoglobulin lambda-like polypeptide 1 (human) namespace: protein def: "An immunoglobulin lambda-like polypeptide 1 that is encoded in the genome of human." [PRO:WCB, UniProtKB:P15814] comment: Category=organism-gene. synonym: "CD179 antigen-like family member B (human)" EXACT [UniProtKB:P15814] synonym: "CD179b (human)" EXACT [UniProtKB:P15814] synonym: "hIGLL1" EXACT PRO-short-label [PRO:DNx] synonym: "Ig lambda-5 (human)" EXACT [UniProtKB:P15814] synonym: "IGL1" RELATED Gene-based [UniProtKB:P15814] synonym: "IGLL1" RELATED Gene-based [UniProtKB:P15814] synonym: "immunoglobulin omega polypeptide (human)" EXACT [UniProtKB:P15814] synonym: "immunoglobulin-related protein 14.1 (human)" EXACT [UniProtKB:P15814] xref: UniProtKB:P15814 is_a: PR:000001859 ! immunoglobulin lambda-like polypeptide 1 is_a: PR:000029067 ! Homo sapiens protein intersection_of: PR:000001859 ! immunoglobulin lambda-like polypeptide 1 intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:P15918 name: V(D)J recombination-activating protein 1 (human) namespace: protein def: "A V(D)J recombination-activating protein 1 that is encoded in the genome of human." [PRO:CNA, UniProtKB:P15918] comment: Category=organism-gene. synonym: "hRAG1" EXACT PRO-short-label [PRO:DNx] synonym: "RAG-1 (human)" EXACT [UniProtKB:P15918] synonym: "RAG1" RELATED Gene-based [UniProtKB:P15918] synonym: "RING finger protein 74 (human)" EXACT [UniProtKB:P15918] synonym: "RNF74" RELATED Gene-based [UniProtKB:P15918] xref: Reactome:R-HSA-5692681 "PR:P15918 located_in GO:0005654" xref: UniProtKB:P15918 is_a: PR:000003457 ! V(D)J recombination-activating protein 1 is_a: PR:000029067 ! Homo sapiens protein intersection_of: PR:000003457 ! V(D)J recombination-activating protein 1 intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:P15919 name: V(D)J recombination-activating protein 1 (mouse) namespace: protein def: "A V(D)J recombination-activating protein 1 that is encoded in the genome of mouse." [OMA:P15919, PRO:DNx] comment: Category=organism-gene. synonym: "mRAG1" EXACT PRO-short-label [PRO:DNx] synonym: "RAG-1 (mouse)" EXACT [UniProtKB:P15919] synonym: "Rag1" RELATED Gene-based [UniProtKB:P15919] xref: UniProtKB:P15919 is_a: PR:000003457 ! V(D)J recombination-activating protein 1 is_a: PR:000029032 ! Mus musculus protein intersection_of: PR:000003457 ! V(D)J recombination-activating protein 1 intersection_of: RO:0002160 NCBITaxon:10090 ! only in taxon Mus musculus [Term] id: PR:P15976 name: erythroid transcription factor (human) namespace: protein def: "An erythroid transcription factor that is encoded in the genome of human." [PRO:DNx, UniProtKB:P15976] comment: Category=organism-gene. synonym: "ERYF1" RELATED Gene-based [UniProtKB:P15976] synonym: "GATA-1 (human)" EXACT [UniProtKB:P15976] synonym: "GATA-binding factor 1 (human)" EXACT [UniProtKB:P15976] synonym: "GATA1" RELATED Gene-based [UniProtKB:P15976] synonym: "GF-1 (human)" BROAD [UniProtKB:P15976] synonym: "GF1" RELATED Gene-based [UniProtKB:P15976] synonym: "hGATA1" EXACT PRO-short-label [PRO:DNx] synonym: "NF-E1 DNA-binding protein (human)" EXACT [UniProtKB:P15976] xref: Reactome:R-HSA-996772 "PR:P15976 located_in GO:0005654" xref: UniProtKB:P15976 is_a: PR:000007857 ! erythroid transcription factor is_a: PR:000029067 ! Homo sapiens protein intersection_of: PR:000007857 ! erythroid transcription factor intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:P16015 name: carbonic anhydrase 3 (mouse) namespace: protein def: "A carbonic anhydrase 3 that is encoded in the genome of mouse." [OMA:P16015, PRO:DNx] comment: Category=organism-gene. synonym: "CA-III (mouse)" EXACT [UniProtKB:P16015] synonym: "Ca3" RELATED Gene-based [UniProtKB:P16015] synonym: "Car3" RELATED Gene-based [UniProtKB:P16015] synonym: "carbonate dehydratase III (mouse)" EXACT [UniProtKB:P16015] synonym: "carbonic anhydrase III (mouse)" EXACT [UniProtKB:P16015] synonym: "mCA3" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:P16015 is_a: PR:000004919 ! carbonic anhydrase 3 is_a: PR:000029032 ! Mus musculus protein intersection_of: PR:000004919 ! carbonic anhydrase 3 intersection_of: RO:0002160 NCBITaxon:10090 ! only in taxon Mus musculus [Term] id: PR:P16045 name: galectin-1 (mouse) namespace: protein def: "A galectin-1 that is encoded in the genome of mouse." [OMA:P16045, PRO:DNx] comment: Category=organism-gene. synonym: "14 kDa lectin (mouse)" EXACT [UniProtKB:P16045] synonym: "beta-galactoside-binding lectin L-14-I (mouse)" EXACT [UniProtKB:P16045] synonym: "gal-1 (mouse)" EXACT [UniProtKB:P16045] synonym: "galaptin (mouse)" EXACT [UniProtKB:P16045] synonym: "Gbp" RELATED Gene-based [UniProtKB:P16045] synonym: "lactose-binding lectin 1 (mouse)" EXACT [UniProtKB:P16045] synonym: "lectin galactoside-binding soluble 1 (mouse)" EXACT [UniProtKB:P16045] synonym: "Lgals1" RELATED Gene-based [UniProtKB:P16045] synonym: "mLGALS1" EXACT PRO-short-label [PRO:DNx] synonym: "S-Lac lectin 1 (mouse)" EXACT [UniProtKB:P16045] xref: UniProtKB:P16045 is_a: PR:000009766 ! galectin-1 is_a: PR:000029032 ! Mus musculus protein intersection_of: PR:000009766 ! galectin-1 intersection_of: RO:0002160 NCBITaxon:10090 ! only in taxon Mus musculus [Term] id: PR:P16070 name: CD44 antigen (human) namespace: protein def: "A CD44 molecule that is encoded in the genome of human." [PRO:WCB, UniProtKB:P16070] comment: Category=organism-gene. synonym: "CD44" RELATED Gene-based [UniProtKB:P16070] synonym: "CDw44 (human)" EXACT [UniProtKB:P16070] synonym: "ECMR-III (human)" EXACT [UniProtKB:P16070] synonym: "epican (human)" EXACT [UniProtKB:P16070] synonym: "extracellular matrix receptor III (human)" EXACT [UniProtKB:P16070] synonym: "GP90 lymphocyte homing/adhesion receptor (human)" EXACT [UniProtKB:P16070] synonym: "hCD44" EXACT PRO-short-label [PRO:DNx] synonym: "heparan sulfate proteoglycan (human)" EXACT [UniProtKB:P16070] synonym: "hermes antigen (human)" EXACT [UniProtKB:P16070] synonym: "HUTCH-I (human)" EXACT [UniProtKB:P16070] synonym: "hyaluronate receptor (human)" EXACT [UniProtKB:P16070] synonym: "LHR" RELATED Gene-based [UniProtKB:P16070] synonym: "MDU2" RELATED Gene-based [UniProtKB:P16070] synonym: "MDU3" RELATED Gene-based [UniProtKB:P16070] synonym: "MIC4" RELATED Gene-based [UniProtKB:P16070] synonym: "PGP-1 (human)" EXACT [UniProtKB:P16070] synonym: "PGP-I (human)" BROAD [UniProtKB:P16070] synonym: "phagocytic glycoprotein 1 (human)" EXACT [UniProtKB:P16070] synonym: "phagocytic glycoprotein I (human)" EXACT [UniProtKB:P16070] xref: UniProtKB:P16070 is_a: PR:000001307 ! CD44 molecule is_a: PR:000029067 ! Homo sapiens protein intersection_of: PR:000001307 ! CD44 molecule intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:P16109 name: P-selectin (human) namespace: protein def: "A P-selectin that is encoded in the genome of human." [PRO:WCB, UniProtKB:P16109] comment: Category=organism-gene. synonym: "CD62 antigen-like family member P (human)" EXACT [UniProtKB:P16109] synonym: "CD62P (human)" EXACT [UniProtKB:P16109] synonym: "GMP-140 (human)" EXACT [UniProtKB:P16109] synonym: "GMRP" RELATED Gene-based [UniProtKB:P16109] synonym: "granule membrane protein 140 (human)" EXACT [UniProtKB:P16109] synonym: "GRMP" RELATED Gene-based [UniProtKB:P16109] synonym: "hSELP" EXACT PRO-short-label [PRO:DNx] synonym: "LECAM3 (human)" EXACT [UniProtKB:P16109] synonym: "leukocyte-endothelial cell adhesion molecule 3 (human)" EXACT [UniProtKB:P16109] synonym: "PADGEM (human)" EXACT [UniProtKB:P16109] synonym: "platelet activation dependent granule-external membrane protein (human)" EXACT [UniProtKB:P16109] synonym: "SELP" RELATED Gene-based [UniProtKB:P16109] xref: UniProtKB:P16109 is_a: PR:000001432 ! P-selectin is_a: PR:000029067 ! Homo sapiens protein intersection_of: PR:000001432 ! P-selectin intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:P16150 name: leukosialin (human) namespace: protein def: "A leukosialin that is encoded in the genome of human." [PRO:WCB, UniProtKB:P16150] comment: Category=organism-gene. synonym: "CD43" RELATED Gene-based [UniProtKB:P16150] synonym: "galactoglycoprotein (human)" EXACT [UniProtKB:P16150] synonym: "GALGP (human)" EXACT [UniProtKB:P16150] synonym: "GPL115 (human)" EXACT [UniProtKB:P16150] synonym: "hSPN" EXACT PRO-short-label [PRO:DNx] synonym: "leukocyte sialoglycoprotein (human)" EXACT [UniProtKB:P16150] synonym: "sialophorin (human)" EXACT [UniProtKB:P16150] synonym: "SPN" RELATED Gene-based [UniProtKB:P16150] xref: UniProtKB:P16150 is_a: PR:000001879 ! leukosialin is_a: PR:000029067 ! Homo sapiens protein intersection_of: PR:000001879 ! leukosialin intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:P16234 name: platelet-derived growth factor receptor alpha (human) namespace: protein def: "An alpha-type platelet-derived growth factor receptor that is encoded in the genome of human." [PRO:WCB, UniProtKB:P16234] comment: Category=organism-gene. synonym: "alpha platelet-derived growth factor receptor (human)" EXACT [UniProtKB:P16234] synonym: "alpha-type platelet-derived growth factor receptor (human)" EXACT [UniProtKB:P16234] synonym: "CD140 antigen-like family member A (human)" EXACT [UniProtKB:P16234] synonym: "CD140a (human)" EXACT [UniProtKB:P16234] synonym: "CD140a antigen (human)" EXACT [UniProtKB:P16234] synonym: "hPDGFRA" EXACT PRO-short-label [PRO:DNx] synonym: "PDGF-R-alpha (human)" EXACT [UniProtKB:P16234] synonym: "PDGFR-2 (human)" EXACT [UniProtKB:P16234] synonym: "PDGFR-alpha (human)" EXACT [UniProtKB:P16234] synonym: "PDGFR2" RELATED Gene-based [UniProtKB:P16234] synonym: "PDGFRA" RELATED Gene-based [UniProtKB:P16234] synonym: "platelet-derived growth factor alpha receptor (human)" EXACT [UniProtKB:P16234] synonym: "platelet-derived growth factor receptor 2 (human)" EXACT [UniProtKB:P16234] synonym: "RHEPDGFRA" RELATED Gene-based [UniProtKB:P16234] xref: DTO:03100403 xref: UniProtKB:P16234 is_a: PR:000002030 ! alpha-type platelet-derived growth factor receptor is_a: PR:000029067 ! Homo sapiens protein intersection_of: PR:000002030 ! alpha-type platelet-derived growth factor receptor intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:P16297 name: interleukin-2 receptor subunit beta (mouse) namespace: protein def: "An interleukin-2 receptor subunit beta that is encoded in the genome of mouse." [OMA:P16297, PRO:DNx] comment: Category=organism-gene. synonym: "CD122 (mouse)" EXACT [UniProtKB:P16297] synonym: "high affinity IL-2 receptor subunit beta (mouse)" EXACT [UniProtKB:P16297] synonym: "IL-2 receptor subunit beta (mouse)" EXACT [UniProtKB:P16297] synonym: "IL-2R subunit beta (mouse)" EXACT [UniProtKB:P16297] synonym: "IL-2RB (mouse)" EXACT [UniProtKB:P16297] synonym: "Il2rb" RELATED Gene-based [UniProtKB:P16297] synonym: "mIL2RB" EXACT PRO-short-label [PRO:DNx] synonym: "p70-75 (mouse)" EXACT [UniProtKB:P16297] xref: UniProtKB:P16297 is_a: PR:000001381 ! interleukin-2 receptor subunit beta is_a: PR:000029032 ! Mus musculus protein intersection_of: PR:000001381 ! interleukin-2 receptor subunit beta intersection_of: RO:0002160 NCBITaxon:10090 ! only in taxon Mus musculus [Term] id: PR:P16406 name: glutamyl aminopeptidase (mouse) namespace: protein def: "A glutamyl aminopeptidase that is encoded in the genome of mouse." [OMA:P16406, PRO:DNx] comment: Category=organism-gene. synonym: "aminopeptidase A (mouse)" EXACT [UniProtKB:P16406] synonym: "AP-A (mouse)" EXACT [UniProtKB:P16406] synonym: "BP-1/6C3 antigen (mouse)" EXACT [UniProtKB:P16406] synonym: "CD249 (mouse)" EXACT [UniProtKB:P16406] synonym: "EAP (mouse)" BROAD [UniProtKB:P16406] synonym: "Enpep" RELATED Gene-based [UniProtKB:P16406] synonym: "mENPEP" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:P16406 is_a: PR:000002039 ! glutamyl aminopeptidase is_a: PR:000029032 ! Mus musculus protein intersection_of: PR:000002039 ! glutamyl aminopeptidase intersection_of: RO:0002160 NCBITaxon:10090 ! only in taxon Mus musculus [Term] id: PR:P16410 name: cytotoxic T-lymphocyte protein 4 (human) namespace: protein def: "A cytotoxic T-lymphocyte protein 4 that is encoded in the genome of human." [PRO:WCB, UniProtKB:P16410] comment: Category=organism-gene. synonym: "CD152" RELATED Gene-based [UniProtKB:P16410] synonym: "CTLA-4 (human)" EXACT [UniProtKB:P16410] synonym: "CTLA4" RELATED Gene-based [UniProtKB:P16410] synonym: "cytotoxic T-lymphocyte-associated antigen 4 (human)" EXACT [UniProtKB:P16410] synonym: "hCTLA4" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:P16410 is_a: PR:000001852 ! cytotoxic T-lymphocyte protein 4 is_a: PR:000029067 ! Homo sapiens protein intersection_of: PR:000001852 ! cytotoxic T-lymphocyte protein 4 intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:P16444 name: dipeptidase 1 (human) namespace: protein def: "A dipeptidase 1 that is encoded in the genome of human." [PRO:DNx, UniProtKB:P16444] comment: Category=organism-gene. synonym: "beta-lactamase (human)" EXACT [UniProtKB:P16444] synonym: "dehydropeptidase-I (human)" EXACT [UniProtKB:P16444] synonym: "DPEP1" RELATED Gene-based [UniProtKB:P16444] synonym: "hDPEP1" EXACT PRO-short-label [PRO:DNx] synonym: "hRDP" EXACT [UniProtKB:P16444] synonym: "MDP" RELATED Gene-based [UniProtKB:P16444] synonym: "microsomal dipeptidase (human)" EXACT [UniProtKB:P16444] synonym: "RDP" RELATED Gene-based [UniProtKB:P16444] synonym: "renal dipeptidase (human)" EXACT [UniProtKB:P16444] xref: UniProtKB:P16444 is_a: PR:000006646 ! dipeptidase 1 is_a: PR:000029067 ! Homo sapiens protein intersection_of: PR:000006646 ! dipeptidase 1 intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:P16671 name: platelet glycoprotein 4 (human) namespace: protein def: "A platelet glycoprotein 4 that is encoded in the genome of human." [PRO:WCB, UniProtKB:P16671] comment: Category=organism-gene. synonym: "CD36" RELATED Gene-based [UniProtKB:P16671] synonym: "FAT (human)" EXACT [UniProtKB:P16671] synonym: "fatty acid translocase (human)" EXACT [UniProtKB:P16671] synonym: "glycoprotein IIIb (human)" EXACT [UniProtKB:P16671] synonym: "GP3B" RELATED Gene-based [UniProtKB:P16671] synonym: "GP4" RELATED Gene-based [UniProtKB:P16671] synonym: "GPIIIB (human)" EXACT [UniProtKB:P16671] synonym: "GPIV (human)" EXACT [UniProtKB:P16671] synonym: "hCD36" EXACT PRO-short-label [PRO:DNx] synonym: "leukocyte differentiation antigen CD36 (human)" EXACT [UniProtKB:P16671] synonym: "PAS IV (human)" EXACT [UniProtKB:P16671] synonym: "PAS-4 (human)" EXACT [UniProtKB:P16671] synonym: "platelet collagen receptor (human)" EXACT [UniProtKB:P16671] synonym: "platelet glycoprotein IV (human)" EXACT [UniProtKB:P16671] synonym: "thrombospondin receptor (human)" EXACT [UniProtKB:P16671] xref: UniProtKB:P16671 is_a: PR:000001905 ! platelet glycoprotein 4 is_a: PR:000029067 ! Homo sapiens protein intersection_of: PR:000001905 ! platelet glycoprotein 4 intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:P16871 name: interleukin-7 receptor subunit alpha (human) namespace: protein def: "An interleukin-7 receptor subunit alpha that is encoded in the genome of human." [PRO:WCB, UniProtKB:P16871] comment: Category=organism-gene. synonym: "CD127 (human)" EXACT [UniProtKB:P16871] synonym: "CDw127 (human)" EXACT [UniProtKB:P16871] synonym: "hIL7R" EXACT PRO-short-label [PRO:DNx] synonym: "IL-7 receptor subunit alpha (human)" EXACT [UniProtKB:P16871] synonym: "IL-7R subunit alpha (human)" EXACT [UniProtKB:P16871] synonym: "IL-7R-alpha (human)" EXACT [UniProtKB:P16871] synonym: "IL-7RA (human)" EXACT [UniProtKB:P16871] synonym: "IL7R" RELATED Gene-based [UniProtKB:P16871] xref: UniProtKB:P16871 is_a: PR:000001869 ! interleukin-7 receptor subunit alpha is_a: PR:000029067 ! Homo sapiens protein intersection_of: PR:000001869 ! interleukin-7 receptor subunit alpha intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:P16872 name: interleukin-7 receptor subunit alpha (mouse) namespace: protein def: "An interleukin-7 receptor subunit alpha that is encoded in the genome of mouse." [OMA:P16872, PRO:DNx] comment: Category=organism-gene. synonym: "CD127 (mouse)" EXACT [UniProtKB:P16872] synonym: "IL-7 receptor subunit alpha (mouse)" EXACT [UniProtKB:P16872] synonym: "IL-7R subunit alpha (mouse)" EXACT [UniProtKB:P16872] synonym: "IL-7R-alpha (mouse)" EXACT [UniProtKB:P16872] synonym: "IL-7RA (mouse)" EXACT [UniProtKB:P16872] synonym: "Il7r" RELATED Gene-based [UniProtKB:P16872] synonym: "mIL7R" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:P16872 is_a: PR:000001869 ! interleukin-7 receptor subunit alpha is_a: PR:000029032 ! Mus musculus protein intersection_of: PR:000001869 ! interleukin-7 receptor subunit alpha intersection_of: RO:0002160 NCBITaxon:10090 ! only in taxon Mus musculus [Term] id: PR:P17208 name: POU domain, class 4, transcription factor 1 (mouse) namespace: protein def: "A POU domain, class 4, transcription factor 1 that is encoded in the genome of mouse." [OMA:P17208, PRO:DNx] comment: Category=organism-gene. synonym: "brain-3A (mouse)" EXACT [UniProtKB:P17208] synonym: "brain-specific homeobox/POU domain protein 3A (mouse)" EXACT [UniProtKB:P17208] synonym: "Brn-3" RELATED Gene-based [UniProtKB:P17208] synonym: "Brn-3.0 (mouse)" EXACT [UniProtKB:P17208] synonym: "Brn-3A (mouse)" EXACT [UniProtKB:P17208] synonym: "Brn3" RELATED Gene-based [UniProtKB:P17208] synonym: "Brn3a" RELATED Gene-based [UniProtKB:P17208] synonym: "mPOU4F1" EXACT PRO-short-label [PRO:DNx] synonym: "Pou4f1" RELATED Gene-based [UniProtKB:P17208] xref: UniProtKB:P17208 is_a: PR:000013041 ! POU domain, class 4, transcription factor 1 is_a: PR:000029032 ! Mus musculus protein intersection_of: PR:000013041 ! POU domain, class 4, transcription factor 1 intersection_of: RO:0002160 NCBITaxon:10090 ! only in taxon Mus musculus [Term] id: PR:P17301 name: integrin alpha-2 (human) namespace: protein def: "An integrin alpha-2 that is encoded in the genome of human." [PRO:CNA, UniProtKB:P17301] comment: Category=organism-gene. synonym: "CD49 antigen-like family member B (human)" EXACT [UniProtKB:P17301] synonym: "CD49B" RELATED Gene-based [UniProtKB:P17301] synonym: "collagen receptor (human)" EXACT [UniProtKB:P17301] synonym: "GPIa (human)" EXACT [UniProtKB:P17301] synonym: "hITGA2" EXACT PRO-short-label [PRO:DNx] synonym: "ITGA2" RELATED Gene-based [UniProtKB:P17301] synonym: "platelet membrane glycoprotein Ia (human)" EXACT [UniProtKB:P17301] synonym: "VLA-2 subunit alpha (human)" EXACT [UniProtKB:P17301] xref: UniProtKB:P17301 is_a: PR:000001008 ! integrin alpha-2 is_a: PR:000029067 ! Homo sapiens protein intersection_of: PR:000001008 ! integrin alpha-2 intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:P17433 name: transcription factor PU.1 (mouse) namespace: protein def: "A transcription factor PU.1 that is encoded in the genome of mouse." [OMA:P17433, PRO:DNx] comment: Category=organism-gene. synonym: "31 kDa-transforming protein (mouse)" EXACT [UniProtKB:P17433] synonym: "mSPI1" EXACT PRO-short-label [PRO:DNx] synonym: "SFFV proviral integration 1 protein (mouse)" EXACT [UniProtKB:P17433] synonym: "Sfpi-1" RELATED Gene-based [UniProtKB:P17433] synonym: "Sfpi1" RELATED Gene-based [UniProtKB:P17433] synonym: "Spi1" RELATED Gene-based [UniProtKB:P17433] xref: UniProtKB:P17433 is_a: PR:000001944 ! transcription factor PU.1 is_a: PR:000029032 ! Mus musculus protein intersection_of: PR:000001944 ! transcription factor PU.1 intersection_of: RO:0002160 NCBITaxon:10090 ! only in taxon Mus musculus [Term] id: PR:P17542 name: T-cell acute lymphocytic leukemia protein 1 (human) namespace: protein def: "A T-cell acute lymphocytic leukemia protein 1 that is encoded in the genome of human." [PRO:DNx, UniProtKB:P17542] comment: Category=organism-gene. synonym: "BHLHA17" RELATED Gene-based [UniProtKB:P17542] synonym: "class A basic helix-loop-helix protein 17 (human)" EXACT [UniProtKB:P17542] synonym: "hTAL1" EXACT PRO-short-label [PRO:DNx] synonym: "SCL" RELATED Gene-based [UniProtKB:P17542] synonym: "Stem cell protein (human)" EXACT [UniProtKB:P17542] synonym: "T-cell leukemia/lymphoma protein 5 (human)" EXACT [UniProtKB:P17542] synonym: "TAL-1 (human)" EXACT [UniProtKB:P17542] synonym: "TAL1" RELATED Gene-based [UniProtKB:P17542] synonym: "TCL5" RELATED Gene-based [UniProtKB:P17542] xref: Reactome:R-HSA-8956511 "PR:P17542 located_in GO:0005654" xref: UniProtKB:P17542 is_a: PR:000016043 ! T-cell acute lymphocytic leukemia protein 1 is_a: PR:000029067 ! Homo sapiens protein intersection_of: PR:000016043 ! T-cell acute lymphocytic leukemia protein 1 intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:P17679 name: erythroid transcription factor (mouse) namespace: protein def: "An erythroid transcription factor that is encoded in the genome of mouse." [OMA:P17679, PRO:DNx] comment: Category=organism-gene. synonym: "Eryf1 (mouse)" EXACT [UniProtKB:P17679] synonym: "GATA-1 (mouse)" EXACT [UniProtKB:P17679] synonym: "GATA-binding factor 1 (mouse)" EXACT [UniProtKB:P17679] synonym: "Gata1" RELATED Gene-based [UniProtKB:P17679] synonym: "Gf-1" RELATED Gene-based [UniProtKB:P17679] synonym: "GF-1 (mouse)" EXACT [UniProtKB:P17679] synonym: "mGATA1" EXACT PRO-short-label [PRO:DNx] synonym: "NF-E1 DNA-binding protein (mouse)" EXACT [UniProtKB:P17679] xref: UniProtKB:P17679 is_a: PR:000007857 ! erythroid transcription factor is_a: PR:000029032 ! Mus musculus protein intersection_of: PR:000007857 ! erythroid transcription factor intersection_of: RO:0002160 NCBITaxon:10090 ! only in taxon Mus musculus [Term] id: PR:P17813 name: endoglin (human) namespace: protein def: "An endoglin that is encoded in the genome of human." [PRO:CNA, UniProtKB:P17813] comment: Category=organism-gene. synonym: "CD105 (human)" EXACT [UniProtKB:P17813] synonym: "END" RELATED Gene-based [UniProtKB:P17813] synonym: "ENG" RELATED Gene-based [UniProtKB:P17813] synonym: "hENG" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:P17813 is_a: PR:000001345 ! endoglin is_a: PR:000029067 ! Homo sapiens protein intersection_of: PR:000001345 ! endoglin intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:P17927 name: complement receptor type 1 (human) namespace: protein def: "A complement receptor type 1 that is encoded in the genome of human." [PRO:WCB, UniProtKB:P17927] comment: Category=organism-gene. synonym: "C3b/C4b receptor (human)" EXACT [UniProtKB:P17927] synonym: "C3BR" RELATED Gene-based [UniProtKB:P17927] synonym: "CD35 (human)" EXACT [UniProtKB:P17927] synonym: "CR1" RELATED Gene-based [UniProtKB:P17927] synonym: "hCR1" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:P17927 is_a: PR:000001337 ! complement receptor type 1 is_a: PR:000029067 ! Homo sapiens protein intersection_of: PR:000001337 ! complement receptor type 1 intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:P17947 name: transcription factor PU.1 (human) namespace: protein def: "A transcription factor PU.1 that is encoded in the genome of human." [PRO:WCB, UniProtKB:P17947] comment: Category=organism-gene. synonym: "31 kDa-transforming protein (human)" EXACT [UniProtKB:P17947] synonym: "hSPI1" EXACT PRO-short-label [PRO:DNx] synonym: "SPI1" RELATED Gene-based [UniProtKB:P17947] xref: Reactome:R-HSA-8865503 "PR:P17947 located_in GO:0005654" xref: UniProtKB:P17947 is_a: PR:000001944 ! transcription factor PU.1 is_a: PR:000029067 ! Homo sapiens protein intersection_of: PR:000001944 ! transcription factor PU.1 intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:P18181 name: CD48 antigen (mouse) namespace: protein def: "A CD48 molecule that is encoded in the genome of mouse." [OMA:P18181, PRO:DNx] comment: Category=organism-gene. synonym: "Bcm-1" RELATED Gene-based [UniProtKB:P18181] synonym: "BCM1 surface antigen (mouse)" EXACT [UniProtKB:P18181] synonym: "BLAST-1 (mouse)" EXACT [UniProtKB:P18181] synonym: "Cd48" RELATED Gene-based [UniProtKB:P18181] synonym: "CD48 (mouse)" EXACT [UniProtKB:P18181] synonym: "HM48-1 (mouse)" EXACT [UniProtKB:P18181] synonym: "mCD48" EXACT PRO-short-label [PRO:DNx] synonym: "MRC OX-45 surface antigen (mouse)" EXACT [UniProtKB:P18181] synonym: "sgp-60 (mouse)" EXACT [UniProtKB:P18181] synonym: "signaling lymphocytic activation molecule 2 (mouse)" EXACT [UniProtKB:P18181] synonym: "SLAM family member 2 (mouse)" EXACT [UniProtKB:P18181] synonym: "SLAMF2 (mouse)" EXACT [UniProtKB:P18181] xref: UniProtKB:P18181 is_a: PR:000001308 ! CD48 molecule is_a: PR:000029032 ! Mus musculus protein intersection_of: PR:000001308 ! CD48 molecule intersection_of: RO:0002160 NCBITaxon:10090 ! only in taxon Mus musculus [Term] id: PR:P18337 name: L-selectin (mouse) namespace: protein def: "An L-selectin that is encoded in the genome of mouse." [OMA:P18337, PRO:DNx] comment: Category=organism-gene. synonym: "CD62 antigen-like family member L (mouse)" EXACT [UniProtKB:P18337] synonym: "CD62L (mouse)" EXACT [UniProtKB:P18337] synonym: "LAM-1 (mouse)" EXACT [UniProtKB:P18337] synonym: "LECAM1 (mouse)" EXACT [UniProtKB:P18337] synonym: "leukocyte adhesion molecule 1 (mouse)" EXACT [UniProtKB:P18337] synonym: "leukocyte-endothelial cell adhesion molecule 1 (mouse)" EXACT [UniProtKB:P18337] synonym: "Lnhr" RELATED Gene-based [UniProtKB:P18337] synonym: "Ly-22" RELATED Gene-based [UniProtKB:P18337] synonym: "Ly22" RELATED Gene-based [UniProtKB:P18337] synonym: "lymph node homing receptor (mouse)" EXACT [UniProtKB:P18337] synonym: "lymphocyte antigen 22 (mouse)" EXACT [UniProtKB:P18337] synonym: "lymphocyte surface MEL-14 antigen (mouse)" EXACT [UniProtKB:P18337] synonym: "mSELL" EXACT PRO-short-label [PRO:DNx] synonym: "Sell" RELATED Gene-based [UniProtKB:P18337] xref: UniProtKB:P18337 is_a: PR:000001318 ! L-selectin is_a: PR:000029032 ! Mus musculus protein intersection_of: PR:000001318 ! L-selectin intersection_of: RO:0002160 NCBITaxon:10090 ! only in taxon Mus musculus [Term] id: PR:P18827 name: syndecan-1 (human) namespace: protein def: "A syndecan-1 that is encoded in the genome of human." [PRO:WCB, UniProtKB:P18827] comment: Category=organism-gene. synonym: "CD138 (human)" EXACT [UniProtKB:P18827] synonym: "hSDC1" EXACT PRO-short-label [PRO:DNx] synonym: "SDC" RELATED Gene-based [UniProtKB:P18827] synonym: "SDC1" RELATED Gene-based [UniProtKB:P18827] synonym: "SYND1 (human)" EXACT [UniProtKB:P18827] xref: UniProtKB:P18827 is_a: PR:000001935 ! syndecan-1 is_a: PR:000029067 ! Homo sapiens protein intersection_of: PR:000001935 ! syndecan-1 intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:P18828 name: syndecan-1 (mouse) namespace: protein def: "A syndecan-1 that is encoded in the genome of mouse." [OMA:P18828, PRO:DNx] comment: Category=organism-gene. synonym: "CD138 (mouse)" EXACT [UniProtKB:P18828] synonym: "mSDC1" EXACT PRO-short-label [PRO:DNx] synonym: "Sdc1" RELATED Gene-based [UniProtKB:P18828] synonym: "Synd-1" RELATED Gene-based [UniProtKB:P18828] synonym: "Synd1" RELATED Gene-based [UniProtKB:P18828] synonym: "SYND1 (mouse)" EXACT [UniProtKB:P18828] xref: UniProtKB:P18828 is_a: PR:000001935 ! syndecan-1 is_a: PR:000029032 ! Mus musculus protein intersection_of: PR:000001935 ! syndecan-1 intersection_of: RO:0002160 NCBITaxon:10090 ! only in taxon Mus musculus [Term] id: PR:P19070 name: complement receptor type 2 (mouse) namespace: protein def: "A complement receptor type 2 that is encoded in the genome of mouse." [PRO:WCB] comment: Category=organism-gene. synonym: "CD21 (mouse)" EXACT [UniProtKB:P19070] synonym: "complement C3d receptor (mouse)" EXACT [UniProtKB:P19070] synonym: "Cr2" RELATED Gene-based [UniProtKB:P19070] synonym: "mCR2" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:P19070 is_a: PR:000001338 ! complement receptor type 2 is_a: PR:000029032 ! Mus musculus protein intersection_of: PR:000001338 ! complement receptor type 2 intersection_of: RO:0002160 NCBITaxon:10090 ! only in taxon Mus musculus [Term] id: PR:P19246 name: neurofilament heavy polypeptide (mouse) namespace: protein def: "A neurofilament heavy polypeptide that is encoded in the genome of mouse." [OMA:P19246, PRO:DNx] comment: Category=organism-gene. synonym: "200 kDa neurofilament protein (mouse)" EXACT [UniProtKB:P19246] synonym: "Kiaa0845" RELATED Gene-based [UniProtKB:P19246] synonym: "mNEFH" EXACT PRO-short-label [PRO:DNx] synonym: "Nefh" RELATED Gene-based [UniProtKB:P19246] synonym: "neurofilament triplet H protein (mouse)" EXACT [UniProtKB:P19246] synonym: "NF-H (mouse)" EXACT [UniProtKB:P19246] synonym: "Nfh" RELATED Gene-based [UniProtKB:P19246] xref: UniProtKB:P19246 is_a: PR:000011118 ! neurofilament heavy polypeptide is_a: PR:000029032 ! Mus musculus protein intersection_of: PR:000011118 ! neurofilament heavy polypeptide intersection_of: RO:0002160 NCBITaxon:10090 ! only in taxon Mus musculus [Term] id: PR:P19437 name: B-lymphocyte antigen CD20 (mouse) namespace: protein def: "A membrane-spanning 4-domains subfamily A member 1 that is encoded in the genome of mouse." [OMA:P19437, PRO:DNx] comment: Category=organism-gene. synonym: "B-cell differentiation antigen Ly-44 (mouse)" EXACT [UniProtKB:P19437] synonym: "Cd20" RELATED Gene-based [UniProtKB:P19437] synonym: "CD20 (mouse)" EXACT [UniProtKB:P19437] synonym: "Ly-44" RELATED Gene-based [UniProtKB:P19437] synonym: "lymphocyte antigen 44 (mouse)" EXACT [UniProtKB:P19437] synonym: "membrane-spanning 4-domains subfamily A member 1 (mouse)" EXACT [UniProtKB:P19437] synonym: "mMS4A1" EXACT PRO-short-label [PRO:DNx] synonym: "Ms4a1" RELATED Gene-based [UniProtKB:P19437] synonym: "Ms4a2" RELATED Gene-based [UniProtKB:P19437] xref: UniProtKB:P19437 is_a: PR:000001289 ! membrane-spanning 4-domains subfamily A member 1 is_a: PR:000029032 ! Mus musculus protein intersection_of: PR:000001289 ! membrane-spanning 4-domains subfamily A member 1 intersection_of: RO:0002160 NCBITaxon:10090 ! only in taxon Mus musculus [Term] id: PR:P19785 name: estrogen receptor (mouse) namespace: protein def: "An estrogen receptor that is encoded in the genome of mouse." [OMA:P19785, PRO:DNx] comment: Category=organism-gene. synonym: "ER (mouse)" EXACT [UniProtKB:P19785] synonym: "ER-alpha (mouse)" EXACT [UniProtKB:P19785] synonym: "Esr" RELATED Gene-based [UniProtKB:P19785] synonym: "Esr1" RELATED Gene-based [UniProtKB:P19785] synonym: "Estr" RELATED Gene-based [UniProtKB:P19785] synonym: "Estra" RELATED Gene-based [UniProtKB:P19785] synonym: "estradiol receptor (mouse)" EXACT [UniProtKB:P19785] synonym: "mESR1" EXACT PRO-short-label [PRO:DNx] synonym: "Nr3a1" RELATED Gene-based [UniProtKB:P19785] synonym: "nuclear receptor subfamily 3 group A member 1 (mouse)" EXACT [UniProtKB:P19785] xref: UniProtKB:P19785 is_a: PR:000007204 ! estrogen receptor is_a: PR:000029032 ! Mus musculus protein intersection_of: PR:000007204 ! estrogen receptor intersection_of: RO:0002160 NCBITaxon:10090 ! only in taxon Mus musculus [Term] id: PR:P20023 name: complement receptor type 2 (human) namespace: protein def: "A complement receptor type 2 that is encoded in the genome of human." [PRO:WCB, UniProtKB:P20023] comment: Category=organism-gene. synonym: "C3DR" RELATED Gene-based [UniProtKB:P20023] synonym: "CD21 (human)" EXACT [UniProtKB:P20023] synonym: "complement C3d receptor (human)" EXACT [UniProtKB:P20023] synonym: "CR2" RELATED Gene-based [UniProtKB:P20023] synonym: "Cr2 (human)" EXACT [UniProtKB:P20023] synonym: "EBV receptor (human)" EXACT [UniProtKB:P20023] synonym: "epstein-Barr virus receptor (human)" EXACT [UniProtKB:P20023] synonym: "hCR2" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:P20023 is_a: PR:000001338 ! complement receptor type 2 is_a: PR:000029067 ! Homo sapiens protein intersection_of: PR:000001338 ! complement receptor type 2 intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:P20138 name: myeloid cell surface antigen CD33 (human) namespace: protein def: "A CD33 molecule that is encoded in the genome of human." [PRO:WCB, UniProtKB:P20138] comment: Category=organism-gene. synonym: "CD33" RELATED Gene-based [UniProtKB:P20138] synonym: "gp67 (human)" EXACT [UniProtKB:P20138] synonym: "hCD33" EXACT PRO-short-label [PRO:DNx] synonym: "sialic acid-binding Ig-like lectin 3 (human)" EXACT [UniProtKB:P20138] synonym: "siglec-3 (human)" EXACT [UniProtKB:P20138] synonym: "SIGLEC3" RELATED Gene-based [UniProtKB:P20138] xref: UniProtKB:P20138 is_a: PR:000001892 ! CD33 molecule is_a: PR:000029067 ! Homo sapiens protein intersection_of: PR:000001892 ! CD33 molecule intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:P20152 name: vimentin (mouse) namespace: protein def: "A vimentin that is encoded in the genome of mouse." [OMA:P20152, PRO:DNx] comment: Category=organism-gene. synonym: "mVIM" EXACT PRO-short-label [PRO:DNx] synonym: "Vim" RELATED Gene-based [UniProtKB:P20152] xref: UniProtKB:P20152 is_a: PR:000017298 ! vimentin is_a: PR:000029032 ! Mus musculus protein intersection_of: PR:000017298 ! vimentin intersection_of: RO:0002160 NCBITaxon:10090 ! only in taxon Mus musculus [Term] id: PR:P20273 name: B-cell receptor CD22 (human) namespace: protein def: "A B-cell receptor CD22 that is encoded in the genome of human." [PRO:WCB, UniProtKB:P20273] comment: Category=organism-gene. synonym: "B-lymphocyte cell adhesion molecule (human)" EXACT [UniProtKB:P20273] synonym: "BL-CAM (human)" EXACT [UniProtKB:P20273] synonym: "CD22" RELATED Gene-based [UniProtKB:P20273] synonym: "hCD22" EXACT PRO-short-label [PRO:DNx] synonym: "sialic acid-binding Ig-like lectin 2 (human)" EXACT [UniProtKB:P20273] synonym: "siglec-2 (human)" EXACT [UniProtKB:P20273] synonym: "SIGLEC2" RELATED Gene-based [UniProtKB:P20273] synonym: "T-cell surface antigen Leu-14 (human)" EXACT [UniProtKB:P20273] xref: UniProtKB:P20273 is_a: PR:000001288 ! B-cell receptor CD22 is_a: PR:000029067 ! Homo sapiens protein intersection_of: PR:000001288 ! B-cell receptor CD22 intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:P20472 name: parvalbumin alpha (human) namespace: protein def: "A parvalbumin alpha that is encoded in the genome of human." [PRO:DNx, UniProtKB:P20472] comment: Category=organism-gene. synonym: "alpha-parvalbumin (human)" EXACT [UniProtKB:P20472] synonym: "alpha-PV (human)" EXACT [UniProtKB:P20472] synonym: "hPVALB" EXACT PRO-short-label [PRO:DNx] synonym: "PVALB" RELATED Gene-based [UniProtKB:P20472] xref: UniProtKB:P20472 is_a: PR:000013502 ! parvalbumin alpha is_a: PR:000029067 ! Homo sapiens protein intersection_of: PR:000013502 ! parvalbumin alpha intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:P20489 name: high affinity immunoglobulin epsilon receptor subunit alpha (mouse) namespace: protein def: "A high affinity immunoglobulin epsilon receptor subunit alpha that is encoded in the genome of mouse." [OMA:P20489, PRO:DNx] comment: Category=organism-gene. synonym: "Fc-epsilon RI-alpha (mouse)" EXACT [UniProtKB:P20489] synonym: "Fce1a" RELATED Gene-based [UniProtKB:P20489] synonym: "Fcer1a" RELATED Gene-based [UniProtKB:P20489] synonym: "FcERI (mouse)" RELATED [UniProtKB:P20489] synonym: "IgE Fc receptor subunit alpha (mouse)" EXACT [UniProtKB:P20489] synonym: "mFCER1A" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:P20489 is_a: PR:000007431 ! high affinity immunoglobulin epsilon receptor subunit alpha is_a: PR:000029032 ! Mus musculus protein intersection_of: PR:000007431 ! high affinity immunoglobulin epsilon receptor subunit alpha intersection_of: RO:0002160 NCBITaxon:10090 ! only in taxon Mus musculus [Term] id: PR:P20693 name: low affinity immunoglobulin epsilon Fc receptor (mouse) namespace: protein def: "A low affinity immunoglobulin epsilon Fc receptor that is encoded in the genome of mouse." [OMA:P20693, PRO:DNx] comment: Category=organism-gene. synonym: "CD23 (mouse)" EXACT [UniProtKB:P20693] synonym: "Fc-epsilon-RII (mouse)" EXACT [UniProtKB:P20693] synonym: "Fcer2" RELATED Gene-based [UniProtKB:P20693] synonym: "Fcer2a" RELATED Gene-based [UniProtKB:P20693] synonym: "lymphocyte IgE receptor (mouse)" EXACT [UniProtKB:P20693] synonym: "mFCER2" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:P20693 is_a: PR:000001880 ! low affinity immunoglobulin epsilon Fc receptor is_a: PR:000029032 ! Mus musculus protein intersection_of: PR:000001880 ! low affinity immunoglobulin epsilon Fc receptor intersection_of: RO:0002160 NCBITaxon:10090 ! only in taxon Mus musculus [Term] id: PR:P20702 name: integrin alpha-X (human) namespace: protein def: "An integrin alpha-X that is encoded in the genome of human." [] comment: Category=organism-gene. synonym: "CD11 antigen-like family member C (human)" EXACT [UniProtKB:P20702] synonym: "CD11C" RELATED Gene-based [UniProtKB:P20702] synonym: "hITGAX" EXACT PRO-short-label [PRO:DNx] synonym: "ITGAX" RELATED Gene-based [UniProtKB:P20702] synonym: "Leu M5 (human)" EXACT [UniProtKB:P20702] synonym: "leukocyte adhesion glycoprotein p150,95 alpha chain (human)" EXACT [UniProtKB:P20702] synonym: "leukocyte adhesion receptor p150,95 (human)" EXACT [UniProtKB:P20702] xref: UniProtKB:P20702 is_a: PR:000001013 ! integrin alpha-X is_a: PR:000029067 ! Homo sapiens protein intersection_of: PR:000001013 ! integrin alpha-X intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:P20718 name: granzyme H (human) namespace: protein def: "A granzyme H that is encoded in the genome of human." [PRO:CNA, UniProtKB:P20718] comment: Category=organism-gene. synonym: "cathepsin G-like 2 (human)" EXACT [UniProtKB:P20718] synonym: "CCP-X (human)" EXACT [UniProtKB:P20718] synonym: "CGL2" RELATED Gene-based [UniProtKB:P20718] synonym: "CSP-C (human)" EXACT [UniProtKB:P20718] synonym: "CTSGL2" RELATED Gene-based [UniProtKB:P20718] synonym: "cytotoxic serine protease C (human)" EXACT [UniProtKB:P20718] synonym: "cytotoxic T-lymphocyte proteinase (human)" EXACT [UniProtKB:P20718] synonym: "GZMH" RELATED Gene-based [UniProtKB:P20718] synonym: "hGZMH" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:P20718 is_a: PR:000003490 ! granzyme H is_a: PR:000029067 ! Homo sapiens protein intersection_of: PR:000003490 ! granzyme H intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:P20937 name: T-cell surface glycoprotein YE1/48 (mouse) namespace: protein def: "A T-cell surface glycoprotein YE1/48 that is encoded in the genome of mouse." [PRO:DNx, UniProtKB:P20937] comment: Category=organism-gene. synonym: "Klra1" RELATED Gene-based [UniProtKB:P20937] synonym: "Ly-49" RELATED Gene-based [UniProtKB:P20937] synonym: "Ly-49a" RELATED Gene-based [UniProtKB:P20937] synonym: "Ly49" RELATED Gene-based [UniProtKB:P20937] synonym: "Ly49A" RELATED Gene-based [UniProtKB:P20937] synonym: "lymphocyte antigen 49a (mouse)" EXACT [UniProtKB:P20937] synonym: "mKlra1" EXACT PRO-short-label [PRO:DNx] synonym: "T lymphocyte antigen A1 (mouse)" EXACT [UniProtKB:P20937] xref: UniProtKB:P20937 is_a: PR:000009616 ! T-cell surface glycoprotein YE1/48 is_a: PR:000029032 ! Mus musculus protein intersection_of: PR:000009616 ! T-cell surface glycoprotein YE1/48 intersection_of: RO:0002160 NCBITaxon:10090 ! only in taxon Mus musculus [Term] id: PR:P21183 name: interleukin-5 receptor subunit alpha (mouse) namespace: protein def: "An interleukin-5 receptor subunit alpha that is encoded in the genome of mouse." [OMA:P21183, PRO:DNx] comment: Category=organism-gene. synonym: "CD125 (mouse)" EXACT [UniProtKB:P21183] synonym: "IL-5 receptor subunit alpha (mouse)" EXACT [UniProtKB:P21183] synonym: "IL-5R subunit alpha (mouse)" EXACT [UniProtKB:P21183] synonym: "IL-5R-alpha (mouse)" EXACT [UniProtKB:P21183] synonym: "IL-5RA (mouse)" EXACT [UniProtKB:P21183] synonym: "Il5r" RELATED Gene-based [UniProtKB:P21183] synonym: "Il5ra" RELATED Gene-based [UniProtKB:P21183] synonym: "mIL5RA" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:P21183 is_a: PR:000001867 ! interleukin-5 receptor subunit alpha is_a: PR:000029032 ! Mus musculus protein intersection_of: PR:000001867 ! interleukin-5 receptor subunit alpha intersection_of: RO:0002160 NCBITaxon:10090 ! only in taxon Mus musculus [Term] id: PR:P21462 name: fMet-Leu-Phe receptor (human) namespace: protein def: "An fMet-Leu-Phe receptor that is encoded in the genome of human." [PRO:WCB, UniProtKB:P21462] comment: Category=organism-gene. synonym: "fMLP receptor (human)" EXACT [UniProtKB:P21462] synonym: "FPR (human)" EXACT [UniProtKB:P21462] synonym: "FPR1" RELATED Gene-based [UniProtKB:P21462] synonym: "hFPR1" EXACT PRO-short-label [PRO:DNx] synonym: "N-formyl peptide receptor (human)" EXACT [UniProtKB:P21462] synonym: "N-formylpeptide chemoattractant receptor (human)" EXACT [UniProtKB:P21462] xref: DTO:02100098 xref: Reactome:R-HSA-375450 "PR:P21462 located_in GO:0005886" xref: Reactome:R-HSA-6799143 "PR:P21462 located_in GO:0035577" xref: Reactome:R-HSA-6800878 "PR:P21462 located_in GO:0101003" xref: Reactome:R-HSA-6800929 "PR:P21462 located_in GO:0030667" xref: UniProtKB:P21462 is_a: PR:000001580 ! fMet-Leu-Phe receptor is_a: PR:000029067 ! Homo sapiens protein intersection_of: PR:000001580 ! fMet-Leu-Phe receptor intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:P21728 name: D(1A) dopamine receptor (human) namespace: protein def: "A D(1A) dopamine receptor that is encoded in the genome of human." [PRO:WCB, UniProtKB:P21728] comment: Category=organism-gene. synonym: "dopamine D1 receptor (human)" EXACT [UniProtKB:P21728] synonym: "DRD1" RELATED Gene-based [UniProtKB:P21728] synonym: "hDRD1" EXACT PRO-short-label [PRO:DNx] xref: DTO:02100081 xref: Reactome:R-HSA-390853 "PR:P21728 located_in GO:0005886" xref: UniProtKB:P21728 is_a: PR:000001175 ! D(1A) dopamine receptor is_a: PR:000029067 ! Homo sapiens protein intersection_of: PR:000001175 ! D(1A) dopamine receptor intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:P21757 name: macrophage scavenger receptor types I and II (human) namespace: protein def: "A macrophage scavenger receptor types I and II that is encoded in the genome of human." [PRO:WCB, UniProtKB:P21757] comment: Category=organism-gene. synonym: "CD204 (human)" EXACT [UniProtKB:P21757] synonym: "hMSR1" EXACT PRO-short-label [PRO:DNx] synonym: "macrophage acetylated LDL receptor I and II (human)" EXACT [UniProtKB:P21757] synonym: "MSR1" RELATED Gene-based [UniProtKB:P21757] synonym: "SCARA1" RELATED Gene-based [UniProtKB:P21757] synonym: "scavenger receptor class A member 1 (human)" EXACT [UniProtKB:P21757] xref: UniProtKB:P21757 is_a: PR:000001885 ! macrophage scavenger receptor types I and II is_a: PR:000029067 ! Homo sapiens protein intersection_of: PR:000001885 ! macrophage scavenger receptor types I and II intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:P21781 name: fibroblast growth factor 7 (human) namespace: protein def: "A fibroblast growth factor 7 that is encoded in the genome of human." [PRO:DNx, UniProtKB:P21781] comment: Category=organism-gene. synonym: "FGF-7 (human)" EXACT [UniProtKB:P21781] synonym: "FGF7" RELATED Gene-based [UniProtKB:P21781] synonym: "HBGF-7 (human)" EXACT [UniProtKB:P21781] synonym: "heparin-binding growth factor 7 (human)" EXACT [UniProtKB:P21781] synonym: "hFGF7" EXACT PRO-short-label [PRO:DNx] synonym: "keratinocyte growth factor (human)" EXACT [UniProtKB:P21781] synonym: "KGF" RELATED Gene-based [UniProtKB:P21781] xref: UniProtKB:P21781 is_a: PR:000007498 ! fibroblast growth factor 7 is_a: PR:000029067 ! Homo sapiens protein intersection_of: PR:000007498 ! fibroblast growth factor 7 intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:P21784 name: V(D)J recombination-activating protein 2 (mouse) namespace: protein def: "A V(D)J recombination-activating protein 2 that is encoded in the genome of mouse." [OMA:P21784, PRO:DNx] comment: Category=organism-gene. synonym: "mRAG2" EXACT PRO-short-label [PRO:DNx] synonym: "Rag-2" RELATED Gene-based [UniProtKB:P21784] synonym: "RAG-2 (mouse)" EXACT [UniProtKB:P21784] synonym: "Rag2" RELATED Gene-based [UniProtKB:P21784] xref: UniProtKB:P21784 is_a: PR:000003460 ! V(D)J recombination-activating protein 2 is_a: PR:000029032 ! Mus musculus protein intersection_of: PR:000003460 ! V(D)J recombination-activating protein 2 intersection_of: RO:0002160 NCBITaxon:10090 ! only in taxon Mus musculus [Term] id: PR:P21926 name: CD9 antigen (human) namespace: protein def: "A CD9 molecule that is encoded in the genome of human." [PRO:DNx, UniProtKB:P21926] comment: Category=organism-gene. synonym: "5H9 antigen (human)" EXACT [UniProtKB:P21926] synonym: "CD9" RELATED Gene-based [UniProtKB:P21926] synonym: "cell growth-inhibiting gene 2 protein (human)" EXACT [UniProtKB:P21926] synonym: "GIG2" RELATED Gene-based [UniProtKB:P21926] synonym: "hCD9" EXACT PRO-short-label [PRO:DNx] synonym: "leukocyte antigen MIC3 (human)" EXACT [UniProtKB:P21926] synonym: "MIC3" RELATED Gene-based [UniProtKB:P21926] synonym: "motility-related protein (human)" EXACT [UniProtKB:P21926] synonym: "MRP-1 (human)" EXACT [UniProtKB:P21926] synonym: "p24 (human)" BROAD [UniProtKB:P21926] synonym: "tetraspanin-29 (human)" EXACT [UniProtKB:P21926] synonym: "tspan-29 (human)" EXACT [UniProtKB:P21926] synonym: "TSPAN29" RELATED Gene-based [UniProtKB:P21926] xref: UniProtKB:P21926 is_a: PR:000005178 ! CD9 molecule is_a: PR:000029067 ! Homo sapiens protein intersection_of: PR:000005178 ! CD9 molecule intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:P22005 name: proenkephalin-A (mouse) namespace: protein def: "A proenkephalin-A that is encoded in the genome of mouse." [OMA:P22005, PRO:DNx] comment: Category=organism-gene. synonym: "mPENK" EXACT PRO-short-label [PRO:DNx] synonym: "Penk" RELATED Gene-based [UniProtKB:P22005] synonym: "Penk1" RELATED Gene-based [UniProtKB:P22005] xref: UniProtKB:P22005 is_a: PR:000012544 ! proenkephalin-A is_a: PR:000029032 ! Mus musculus protein intersection_of: PR:000012544 ! proenkephalin-A intersection_of: RO:0002160 NCBITaxon:10090 ! only in taxon Mus musculus [Term] id: PR:P22083 name: alpha-(1,3)-fucosyltransferase 4 (human) namespace: protein def: "An alpha-(1,3)-fucosyltransferase 4 that is encoded in the genome of human." [PRO:CNA, UniProtKB:P22083] comment: Category=organism-gene. synonym: "4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase (human)" RELATED [UniProtKB:P22083] synonym: "ELAM-1 ligand fucosyltransferase (human)" EXACT [UniProtKB:P22083] synonym: "ELFT" RELATED Gene-based [UniProtKB:P22083] synonym: "FCT3A" RELATED Gene-based [UniProtKB:P22083] synonym: "Fuc-TIV (human)" EXACT [UniProtKB:P22083] synonym: "fucosyltransferase 4 (human)" EXACT [UniProtKB:P22083] synonym: "fucosyltransferase IV (human)" EXACT [UniProtKB:P22083] synonym: "FucT-IV (human)" EXACT [UniProtKB:P22083] synonym: "FUT4" RELATED Gene-based [UniProtKB:P22083] synonym: "galactoside 3-L-fucosyltransferase (human)" BROAD [UniProtKB:P22083] synonym: "hFUT4" EXACT PRO-short-label [PRO:DNx] xref: Reactome:R-HSA-9034106 "PR:P22083 located_in GO:0000139" xref: UniProtKB:P22083 is_a: PR:000001456 ! alpha-(1,3)-fucosyltransferase 4 is_a: PR:000029067 ! Homo sapiens protein intersection_of: PR:000001456 ! alpha-(1,3)-fucosyltransferase 4 intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:P22091 name: T-cell acute lymphocytic leukemia protein 1 homolog (mouse) namespace: protein def: "A T-cell acute lymphocytic leukemia protein 1 that is encoded in the genome of mouse." [OMA:P22091, PRO:DNx] comment: Category=organism-gene. synonym: "mTAL1" EXACT PRO-short-label [PRO:DNx] synonym: "Scl" RELATED Gene-based [UniProtKB:P22091] synonym: "Stem cell protein (mouse)" EXACT [UniProtKB:P22091] synonym: "Tal-1" RELATED Gene-based [UniProtKB:P22091] synonym: "TAL-1 (mouse)" EXACT [UniProtKB:P22091] synonym: "Tal1" RELATED Gene-based [UniProtKB:P22091] xref: UniProtKB:P22091 is_a: PR:000016043 ! T-cell acute lymphocytic leukemia protein 1 is_a: PR:000029032 ! Mus musculus protein intersection_of: PR:000016043 ! T-cell acute lymphocytic leukemia protein 1 intersection_of: RO:0002160 NCBITaxon:10090 ! only in taxon Mus musculus [Term] id: PR:P22387 name: endothelin-1 (mouse) namespace: protein def: "An endothelin-1 that is encoded in the genome of mouse." [OMA:P22387, PRO:DNx] comment: Category=organism-gene. synonym: "Edn1" RELATED Gene-based [UniProtKB:P22387] synonym: "ET-1 (mouse)" EXACT [UniProtKB:P22387] synonym: "mEDN1" EXACT PRO-short-label [PRO:DNx] synonym: "PPET1 (mouse)" EXACT [UniProtKB:P22387] synonym: "preproendothelin-1 (mouse)" EXACT [UniProtKB:P22387] xref: UniProtKB:P22387 is_a: PR:000006897 ! endothelin-1 is_a: PR:000029032 ! Mus musculus protein intersection_of: PR:000006897 ! endothelin-1 intersection_of: RO:0002160 NCBITaxon:10090 ! only in taxon Mus musculus [Term] id: PR:P22466 name: galanin peptides (human) namespace: protein def: "A galanin that is encoded in the genome of human." [PRO:DNx, UniProtKB:P22466] comment: Category=organism-gene. synonym: "GAL" RELATED Gene-based [UniProtKB:P22466] synonym: "GAL1" RELATED Gene-based [UniProtKB:P22466] synonym: "GALN" RELATED Gene-based [UniProtKB:P22466] synonym: "GLNN" RELATED Gene-based [UniProtKB:P22466] synonym: "hGAL" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:P22466 is_a: PR:000007806 ! galanin is_a: PR:000029067 ! Homo sapiens protein intersection_of: PR:000007806 ! galanin intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:P22646 name: T-cell surface glycoprotein CD3 epsilon chain (mouse) namespace: protein def: "A CD3 epsilon that is encoded in the genome of mouse." [OMA:P22646, PRO:DNx] comment: Category=organism-gene. synonym: "Cd3e" RELATED Gene-based [UniProtKB:P22646] synonym: "CD3e (mouse)" EXACT [UniProtKB:P22646] synonym: "mCD3E" EXACT PRO-short-label [PRO:DNx] synonym: "T-cell surface antigen T3/Leu-4 epsilon chain (mouse)" EXACT [UniProtKB:P22646] xref: UniProtKB:P22646 is_a: PR:000001020 ! CD3 epsilon is_a: PR:000029032 ! Mus musculus protein intersection_of: PR:000001020 ! CD3 epsilon intersection_of: RO:0002160 NCBITaxon:10090 ! only in taxon Mus musculus [Term] id: PR:P22858 name: parathyroid hormone-related protein (mouse) namespace: protein def: "A parathyroid hormone-related protein that is encoded in the genome of mouse." [OMA:P22858, PRO:DNx] comment: Category=organism-gene. synonym: "mPTHLH" EXACT PRO-short-label [PRO:DNx] synonym: "parathyroid hormone-like protein (mouse)" EXACT [UniProtKB:P22858] synonym: "PLP (mouse)" RELATED [UniProtKB:P22858] synonym: "PTH-rP (mouse)" EXACT [UniProtKB:P22858] synonym: "Pthlh" RELATED Gene-based [UniProtKB:P22858] synonym: "Pthrp" RELATED Gene-based [UniProtKB:P22858] synonym: "PTHrP (mouse)" EXACT [UniProtKB:P22858] xref: UniProtKB:P22858 is_a: PR:000013433 ! parathyroid hormone-related protein is_a: PR:000029032 ! Mus musculus protein intersection_of: PR:000013433 ! parathyroid hormone-related protein intersection_of: RO:0002160 NCBITaxon:10090 ! only in taxon Mus musculus [Term] id: PR:P22897 name: macrophage mannose receptor 1 (human) namespace: protein def: "A macrophage mannose receptor 1 that is encoded in the genome of human." [PRO:CNA, UniProtKB:P22897] comment: Category=organism-gene. synonym: "C-type lectin domain family 13 member D (human)" EXACT [UniProtKB:P22897] synonym: "C-type lectin domain family 13 member D-like (human)" EXACT [UniProtKB:P22897] synonym: "CD206 (human)" EXACT [UniProtKB:P22897] synonym: "CLEC13D" RELATED Gene-based [UniProtKB:P22897] synonym: "CLEC13DL" RELATED Gene-based [UniProtKB:P22897] synonym: "hMR" EXACT [UniProtKB:P22897] synonym: "hMRC1" EXACT PRO-short-label [PRO:DNx] synonym: "human mannose receptor" EXACT [UniProtKB:P22897] synonym: "macrophage mannose receptor 1-like protein 1 (human)" EXACT [UniProtKB:P22897] synonym: "MMR (human)" EXACT [UniProtKB:P22897] synonym: "MRC1" RELATED Gene-based [UniProtKB:P22897] synonym: "MRC1L1" RELATED Gene-based [UniProtKB:P22897] xref: UniProtKB:P22897 is_a: PR:000002972 ! macrophage mannose receptor 1 is_a: PR:000029067 ! Homo sapiens protein intersection_of: PR:000002972 ! macrophage mannose receptor 1 intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:P23769 name: endothelial transcription factor GATA-2 (human) namespace: protein def: "An endothelial transcription factor GATA-2 that is encoded in the genome of human." [PRO:DNx, UniProtKB:P23769] comment: Category=organism-gene. synonym: "GATA-binding protein 2 (human)" EXACT [UniProtKB:P23769] synonym: "GATA2" RELATED Gene-based [UniProtKB:P23769] synonym: "hGATA2" EXACT PRO-short-label [PRO:DNx] xref: Reactome:R-HSA-996735 "PR:P23769 located_in GO:0005654" xref: UniProtKB:P23769 is_a: PR:000007858 ! endothelial transcription factor GATA-2 is_a: PR:000029067 ! Homo sapiens protein intersection_of: PR:000007858 ! endothelial transcription factor GATA-2 intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:P23771 name: trans-acting T-cell-specific transcription factor GATA-3 (human) namespace: protein def: "A trans-acting T-cell-specific transcription factor GATA-3 that is encoded in the genome of human." [PRO:WCB, UniProtKB:P23771] comment: Category=organism-gene. synonym: "GATA-binding factor 3 (human)" EXACT [UniProtKB:P23771] synonym: "GATA3" RELATED Gene-based [UniProtKB:P23771] synonym: "hGATA3" EXACT PRO-short-label [PRO:DNx] xref: Reactome:R-HSA-996768 "PR:P23771 located_in GO:0005654" xref: UniProtKB:P23771 is_a: PR:000001941 ! trans-acting T-cell-specific transcription factor GATA-3 is_a: PR:000029067 ! Homo sapiens protein intersection_of: PR:000001941 ! trans-acting T-cell-specific transcription factor GATA-3 intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:P23772 name: trans-acting T-cell-specific transcription factor GATA-3 (mouse) namespace: protein def: "A trans-acting T-cell-specific transcription factor GATA-3 that is encoded in the genome of mouse." [OMA:P23772, PRO:DNx] comment: Category=organism-gene. synonym: "Gata-3" RELATED Gene-based [UniProtKB:P23772] synonym: "GATA-binding factor 3 (mouse)" EXACT [UniProtKB:P23772] synonym: "Gata3" RELATED Gene-based [UniProtKB:P23772] synonym: "mGATA3" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:P23772 is_a: PR:000001941 ! trans-acting T-cell-specific transcription factor GATA-3 is_a: PR:000029032 ! Mus musculus protein intersection_of: PR:000001941 ! trans-acting T-cell-specific transcription factor GATA-3 intersection_of: RO:0002160 NCBITaxon:10090 ! only in taxon Mus musculus [Term] id: PR:P24529 name: tyrosine 3-monooxygenase (mouse) namespace: protein def: "A tyrosine 3-monooxygenase that is encoded in the genome of mouse." [OMA:P24529, PRO:DNx] comment: Category=organism-gene. synonym: "mTH" EXACT PRO-short-label [PRO:DNx] synonym: "Th" RELATED Gene-based [UniProtKB:P24529] synonym: "TH (mouse)" EXACT [UniProtKB:P24529] synonym: "tyrosine 3-hydroxylase (mouse)" EXACT [UniProtKB:P24529] xref: UniProtKB:P24529 is_a: PR:000016301 ! tyrosine 3-monooxygenase is_a: PR:000029032 ! Mus musculus protein intersection_of: PR:000016301 ! tyrosine 3-monooxygenase intersection_of: RO:0002160 NCBITaxon:10090 ! only in taxon Mus musculus [Term] id: PR:P24807 name: signal transducer CD24 (mouse) namespace: protein def: "A signal transducer CD24 that is encoded in the genome of mouse." [OMA:P24807, PRO:WCB] comment: Category=organism-gene. synonym: "Cd24" RELATED Gene-based [UniProtKB:P24807] synonym: "CD24 (mouse)" EXACT [UniProtKB:P24807] synonym: "Cd24a" RELATED Gene-based [UniProtKB:P24807] synonym: "HSA (mouse)" EXACT [UniProtKB:P24807] synonym: "Ly-52" RELATED Gene-based [UniProtKB:P24807] synonym: "lymphocyte antigen 52 (mouse)" EXACT [UniProtKB:P24807] synonym: "M1/69-J11D heat stable antigen (mouse)" EXACT [UniProtKB:P24807] synonym: "mCD24" EXACT PRO-short-label [PRO:DNx] synonym: "nectadrin (mouse)" EXACT [UniProtKB:P24807] synonym: "R13-Ag (mouse)" EXACT [UniProtKB:P24807] synonym: "X62 heat stable antigen (mouse)" EXACT [UniProtKB:P24807] xref: UniProtKB:P24807 is_a: PR:000001932 ! signal transducer CD24 is_a: PR:000029032 ! Mus musculus protein intersection_of: PR:000001932 ! signal transducer CD24 intersection_of: RO:0002160 NCBITaxon:10090 ! only in taxon Mus musculus [Term] id: PR:P25024 name: C-X-C chemokine receptor type 1 (human) namespace: protein def: "A C-X-C chemokine receptor type 1 that is encoded in the genome of human." [PRO:WCB, UniProtKB:P25024] comment: Category=organism-gene. synonym: "CD181 (human)" EXACT [UniProtKB:P25024] synonym: "CDw128a (human)" EXACT [UniProtKB:P25024] synonym: "CMKAR1" RELATED Gene-based [UniProtKB:P25024] synonym: "CXC-R1 (human)" EXACT [UniProtKB:P25024] synonym: "CXCR-1 (human)" EXACT [UniProtKB:P25024] synonym: "CXCR1" RELATED Gene-based [UniProtKB:P25024] synonym: "hCXCR1" EXACT PRO-short-label [PRO:DNx] synonym: "high affinity interleukin-8 receptor A (human)" EXACT [UniProtKB:P25024] synonym: "IL-8 receptor type 1 (human)" EXACT [UniProtKB:P25024] synonym: "IL-8R A (human)" EXACT [UniProtKB:P25024] synonym: "IL8RA" RELATED Gene-based [UniProtKB:P25024] xref: DTO:02100075 xref: Reactome:R-HSA-373805 "PR:P25024 located_in GO:0005886" xref: Reactome:R-HSA-6804780 "PR:P25024 located_in GO:0030667" xref: UniProtKB:P25024 is_a: PR:000001256 ! C-X-C chemokine receptor type 1 is_a: PR:000029067 ! Homo sapiens protein intersection_of: PR:000001256 ! C-X-C chemokine receptor type 1 intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:P25025 name: C-X-C chemokine receptor type 2 (human) namespace: protein def: "A C-X-C chemokine receptor type 2 that is encoded in the genome of human." [PRO:WCB, UniProtKB:P25025] comment: Category=organism-gene. Requested by=PubChem. synonym: "CD182 (human)" EXACT [UniProtKB:P25025] synonym: "CDw128b (human)" EXACT [UniProtKB:P25025] synonym: "CXC-R2 (human)" EXACT [UniProtKB:P25025] synonym: "CXCR-2 (human)" EXACT [UniProtKB:P25025] synonym: "CXCR2" RELATED Gene-based [UniProtKB:P25025] synonym: "GRO/MGSA receptor (human)" EXACT [UniProtKB:P25025] synonym: "hCXCR2" EXACT PRO-short-label [PRO:DNx] synonym: "high affinity interleukin-8 receptor B (human)" EXACT [UniProtKB:P25025] synonym: "IL-8 receptor type 2 (human)" EXACT [UniProtKB:P25025] synonym: "IL-8R B (human)" EXACT [UniProtKB:P25025] synonym: "IL8RB" RELATED Gene-based [UniProtKB:P25025] xref: DTO:02100076 xref: Reactome:R-HSA-373796 "PR:P25025 located_in GO:0005886" xref: Reactome:R-HSA-6804771 "PR:P25025 located_in GO:0030667" xref: UniProtKB:P25025 is_a: PR:000001257 ! C-X-C chemokine receptor type 2 is_a: PR:000029067 ! Homo sapiens protein intersection_of: PR:000001257 ! C-X-C chemokine receptor type 2 intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:P25063 name: signal transducer CD24 (human) namespace: protein def: "A signal transducer CD24 that is encoded in the genome of human." [PRO:WCB, UniProtKB:P25063] comment: Category=organism-gene. synonym: "CD24" RELATED Gene-based [UniProtKB:P25063] synonym: "CD24A" RELATED Gene-based [UniProtKB:P25063] synonym: "hCD24" EXACT PRO-short-label [PRO:DNx] synonym: "small cell lung carcinoma cluster 4 antigen (human)" EXACT [UniProtKB:P25063] xref: UniProtKB:P25063 is_a: PR:000001932 ! signal transducer CD24 is_a: PR:000029067 ! Homo sapiens protein intersection_of: PR:000001932 ! signal transducer CD24 intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:P25918 name: B-lymphocyte antigen CD19 (mouse) namespace: protein def: "A CD19 molecule that is encoded in the genome of mouse." [OMA:P25918, PRO:DNx] comment: Category=organism-gene. synonym: "Cd19" RELATED Gene-based [UniProtKB:P25918] synonym: "CD19 (mouse)" EXACT [UniProtKB:P25918] synonym: "differentiation antigen CD19 (mouse)" EXACT [UniProtKB:P25918] synonym: "mCD19" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:P25918 is_a: PR:000001002 ! CD19 molecule is_a: PR:000029032 ! Mus musculus protein intersection_of: PR:000001002 ! CD19 molecule intersection_of: RO:0002160 NCBITaxon:10090 ! only in taxon Mus musculus [Term] id: PR:P26010 name: integrin beta-7 (human) namespace: protein def: "An integrin beta-7 that is encoded in the genome of human." [PRO:DNx, UniProtKB:P26010] comment: Category=organism-gene. synonym: "Gut homing receptor beta subunit (human)" EXACT [UniProtKB:P26010] synonym: "hITGB7" EXACT PRO-short-label [PRO:DNx] synonym: "ITGB7" RELATED Gene-based [UniProtKB:P26010] xref: UniProtKB:P26010 is_a: PR:000009143 ! integrin beta-7 is_a: PR:000029067 ! Homo sapiens protein intersection_of: PR:000009143 ! integrin beta-7 intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:P26011 name: integrin beta-7 (mouse) namespace: protein def: "An integrin beta-7 that is encoded in the genome of mouse." [OMA:P26011, PRO:DNx] comment: Category=organism-gene. synonym: "integrin beta-P (mouse)" EXACT [UniProtKB:P26011] synonym: "Itgb7" RELATED Gene-based [UniProtKB:P26011] synonym: "M290 IEL antigen (mouse)" EXACT [UniProtKB:P26011] synonym: "mITGB7" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:P26011 is_a: PR:000009143 ! integrin beta-7 is_a: PR:000029032 ! Mus musculus protein intersection_of: PR:000009143 ! integrin beta-7 intersection_of: RO:0002160 NCBITaxon:10090 ! only in taxon Mus musculus [Term] id: PR:P26151 name: high affinity immunoglobulin gamma Fc receptor I (mouse) namespace: protein def: "A high affinity immunoglobulin gamma Fc receptor I that is encoded in the genome of mouse." [OMA:P26151, PRO:DNx] comment: Category=organism-gene. synonym: "CD64 (mouse)" EXACT [UniProtKB:P26151] synonym: "Fc-gamma RI (mouse)" EXACT [UniProtKB:P26151] synonym: "Fcg1" RELATED Gene-based [UniProtKB:P26151] synonym: "Fcgr1" RELATED Gene-based [UniProtKB:P26151] synonym: "FcRI (mouse)" EXACT [UniProtKB:P26151] synonym: "IgG Fc receptor I (mouse)" EXACT [UniProtKB:P26151] synonym: "mFCGR1A" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:P26151 is_a: PR:000001465 ! high affinity immunoglobulin gamma Fc receptor I is_a: PR:000029032 ! Mus musculus protein intersection_of: PR:000001465 ! high affinity immunoglobulin gamma Fc receptor I intersection_of: RO:0002160 NCBITaxon:10090 ! only in taxon Mus musculus [Term] id: PR:P26367 name: paired box protein Pax-6 (human) namespace: protein def: "A paired box protein Pax-6 that is encoded in the genome of human." [PRO:DNx, UniProtKB:P26367] comment: Category=organism-gene. synonym: "AN2" RELATED Gene-based [UniProtKB:P26367] synonym: "aniridia type II protein (human)" EXACT [UniProtKB:P26367] synonym: "hPAX6" EXACT PRO-short-label [PRO:DNx] synonym: "oculorhombin (human)" EXACT [UniProtKB:P26367] synonym: "PAX6" RELATED Gene-based [UniProtKB:P26367] xref: Reactome:R-HSA-3009044 "PR:P26367 located_in GO:0005654" xref: UniProtKB:P26367 is_a: PR:000012318 ! paired box protein Pax-6 is_a: PR:000029067 ! Homo sapiens protein intersection_of: PR:000012318 ! paired box protein Pax-6 intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:P26618 name: platelet-derived growth factor receptor alpha (mouse) namespace: protein def: "An alpha-type platelet-derived growth factor receptor that is encoded in the genome of mouse." [OMA:P26618, PRO:DNx] comment: Category=organism-gene. synonym: "alpha platelet-derived growth factor receptor (mouse)" EXACT [UniProtKB:P26618] synonym: "alpha-type platelet-derived growth factor receptor (mouse)" EXACT [UniProtKB:P26618] synonym: "CD140 antigen-like family member A (mouse)" EXACT [UniProtKB:P26618] synonym: "CD140a (mouse)" EXACT [UniProtKB:P26618] synonym: "mPDGFRA" EXACT PRO-short-label [PRO:DNx] synonym: "PDGF-R-alpha (mouse)" EXACT [UniProtKB:P26618] synonym: "PDGFR-alpha (mouse)" EXACT [UniProtKB:P26618] synonym: "Pdgfra" RELATED Gene-based [UniProtKB:P26618] synonym: "platelet-derived growth factor alpha receptor (mouse)" EXACT [UniProtKB:P26618] xref: UniProtKB:P26618 is_a: PR:000002030 ! alpha-type platelet-derived growth factor receptor is_a: PR:000029032 ! Mus musculus protein intersection_of: PR:000002030 ! alpha-type platelet-derived growth factor receptor intersection_of: RO:0002160 NCBITaxon:10090 ! only in taxon Mus musculus [Term] id: PR:P26715 name: NKG2-A/NKG2-B type II integral membrane protein (human) namespace: protein def: "An NKG2-A/NKG2-B type II integral membrane protein that is encoded in the genome of human." [PRO:WCB, UniProtKB:P26715] comment: Category=organism-gene. synonym: "CD159 antigen-like family member A (human)" EXACT [UniProtKB:P26715] synonym: "CD159a (human)" EXACT [UniProtKB:P26715] synonym: "hKLRC1" EXACT PRO-short-label [PRO:DNx] synonym: "KLRC1" RELATED Gene-based [UniProtKB:P26715] synonym: "NK cell receptor A (human)" EXACT [UniProtKB:P26715] synonym: "NKG2-A/B-activating NK receptor (human)" EXACT [UniProtKB:P26715] synonym: "NKG2A" RELATED Gene-based [UniProtKB:P26715] xref: Reactome:R-HSA-3006545 "PR:P26715 located_in GO:0005886" xref: UniProtKB:P26715 is_a: PR:000002023 ! NKG2-A/NKG2-B type II integral membrane protein is_a: PR:000029067 ! Homo sapiens protein intersection_of: PR:000002023 ! NKG2-A/NKG2-B type II integral membrane protein intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:P26842 name: CD27 antigen (human) namespace: protein def: "A CD27 molecule that is encoded in the genome of human." [PRO:WCB, UniProtKB:P26842] comment: Category=organism-gene. synonym: "CD27" RELATED Gene-based [UniProtKB:P26842] synonym: "CD27L receptor (human)" EXACT [UniProtKB:P26842] synonym: "hCD27" EXACT PRO-short-label [PRO:DNx] synonym: "T-cell activation antigen CD27 (human)" EXACT [UniProtKB:P26842] synonym: "T14 (human)" EXACT [UniProtKB:P26842] synonym: "TNFRSF7" RELATED Gene-based [UniProtKB:P26842] synonym: "tumor necrosis factor receptor superfamily member 7 (human)" EXACT [UniProtKB:P26842] xref: UniProtKB:P26842 is_a: PR:000001963 ! CD27 molecule is_a: PR:000029067 ! Homo sapiens protein intersection_of: PR:000001963 ! CD27 molecule intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:P26951 name: interleukin-3 receptor subunit alpha (human) namespace: protein def: "An interleukin-3 receptor class 2 alpha chain that is encoded in the genome of human." [PRO:WCB, UniProtKB:P26951] comment: Category=organism-gene. synonym: "CD123 (human)" EXACT [UniProtKB:P26951] synonym: "hIL3RA" EXACT PRO-short-label [PRO:DNx] synonym: "IL-3 receptor subunit alpha (human)" EXACT [UniProtKB:P26951] synonym: "IL-3R subunit alpha (human)" EXACT [UniProtKB:P26951] synonym: "IL-3R-alpha (human)" EXACT [UniProtKB:P26951] synonym: "IL-3RA (human)" EXACT [UniProtKB:P26951] synonym: "IL3R" RELATED Gene-based [UniProtKB:P26951] synonym: "IL3RA" RELATED Gene-based [UniProtKB:P26951] xref: UniProtKB:P26951 is_a: PR:000001865 ! interleukin-3 receptor class 2 alpha chain is_a: PR:000029067 ! Homo sapiens protein intersection_of: PR:000001865 ! interleukin-3 receptor class 2 alpha chain intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:P26952 name: interleukin-3 receptor subunit alpha (mouse) namespace: protein def: "An interleukin-3 receptor class 2 alpha chain that is encoded in the genome of mouse." [OMA:P26952, PRO:DNx] comment: Category=organism-gene. synonym: "CD123 (mouse)" EXACT [UniProtKB:P26952] synonym: "IL-3 receptor subunit alpha (mouse)" EXACT [UniProtKB:P26952] synonym: "IL-3R subunit alpha (mouse)" EXACT [UniProtKB:P26952] synonym: "IL-3R-alpha (mouse)" EXACT [UniProtKB:P26952] synonym: "IL-3RA (mouse)" EXACT [UniProtKB:P26952] synonym: "Il3ra" RELATED Gene-based [UniProtKB:P26952] synonym: "interleukin-3 receptor class II alpha chain (mouse)" EXACT [UniProtKB:P26952] synonym: "mIL3RA" EXACT PRO-short-label [PRO:DNx] synonym: "Sut-1" RELATED Gene-based [UniProtKB:P26952] xref: UniProtKB:P26952 is_a: PR:000001865 ! interleukin-3 receptor class 2 alpha chain is_a: PR:000029032 ! Mus musculus protein intersection_of: PR:000001865 ! interleukin-3 receptor class 2 alpha chain intersection_of: RO:0002160 NCBITaxon:10090 ! only in taxon Mus musculus [Term] id: PR:P27548 name: CD40 ligand (mouse) namespace: protein def: "A tumor necrosis factor ligand superfamily member 5 that is encoded in the genome of mouse." [OMA:P27548, PRO:DNx] comment: Category=organism-gene. synonym: "CD154 (mouse)" EXACT [UniProtKB:P27548] synonym: "CD40-L (mouse)" EXACT [UniProtKB:P27548] synonym: "Cd40l" RELATED Gene-based [UniProtKB:P27548] synonym: "Cd40lg" RELATED Gene-based [UniProtKB:P27548] synonym: "mCD40LG" EXACT PRO-short-label [PRO:DNx] synonym: "T-cell antigen Gp39 (mouse)" EXACT [UniProtKB:P27548] synonym: "TNF-related activation protein (mouse)" EXACT [UniProtKB:P27548] synonym: "Tnfsf5" RELATED Gene-based [UniProtKB:P27548] synonym: "TRAP (mouse)" EXACT [UniProtKB:P27548] synonym: "tumor necrosis factor ligand superfamily member 5 (mouse)" EXACT [UniProtKB:P27548] xref: UniProtKB:P27548 is_a: PR:000001950 ! tumor necrosis factor ligand superfamily member 5 is_a: PR:000029032 ! Mus musculus protein intersection_of: PR:000001950 ! tumor necrosis factor ligand superfamily member 5 intersection_of: RO:0002160 NCBITaxon:10090 ! only in taxon Mus musculus [Term] id: PR:P27797 name: calreticulin (human) namespace: protein def: "A calreticulin that is encoded in the genome of human." [PRO:DNx, UniProtKB:P27797] comment: Category=organism-gene. synonym: "CALR" RELATED Gene-based [UniProtKB:P27797] synonym: "calregulin (human)" EXACT [UniProtKB:P27797] synonym: "CRP55 (human)" EXACT [UniProtKB:P27797] synonym: "CRTC" RELATED Gene-based [UniProtKB:P27797] synonym: "endoplasmic reticulum resident protein 60 (human)" BROAD [UniProtKB:P27797] synonym: "ERp60 (human)" BROAD [UniProtKB:P27797] synonym: "grp60 (human)" EXACT [UniProtKB:P27797] synonym: "HACBP (human)" EXACT [UniProtKB:P27797] synonym: "hCALR" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:P27797 is_a: PR:000004984 ! calreticulin is_a: PR:000029067 ! Homo sapiens protein intersection_of: PR:000004984 ! calreticulin intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:P27814 name: killer cell lectin-like receptor subfamily B member 1C (mouse) namespace: protein def: "A killer cell lectin-like receptor subfamily B member 1C that is encoded in the genome of mouse." [PRO:CNA, UniProtKB:P27814] comment: Category=organism-gene. synonym: "CD161 antigen-like family member C (mouse)" EXACT [UniProtKB:P27814] synonym: "CD161c (mouse)" EXACT [UniProtKB:P27814] synonym: "Klrb1c" RELATED Gene-based [UniProtKB:P27814] synonym: "Ly-55c (mouse)" EXACT [UniProtKB:P27814] synonym: "Ly55c" RELATED Gene-based [UniProtKB:P27814] synonym: "lymphocyte antigen 55c (mouse)" EXACT [UniProtKB:P27814] synonym: "mKlrb1c" EXACT PRO-short-label [PRO:DNx] synonym: "natural killer cell surface protein P1-40 (mouse)" EXACT [UniProtKB:P27814] synonym: "NK1.1 (mouse)" EXACT [UniProtKB:P27814] synonym: "NKR-P1 40 (mouse)" EXACT [UniProtKB:P27814] synonym: "NKR-P1.9 (mouse)" EXACT [UniProtKB:P27814] synonym: "NKR-P1C (mouse)" EXACT [UniProtKB:P27814] synonym: "Nkrp1c" RELATED Gene-based [UniProtKB:P27814] xref: UniProtKB:P27814 is_a: PR:000002977 ! killer cell lectin-like receptor subfamily B member 1C is_a: PR:000029032 ! Mus musculus protein intersection_of: PR:000002977 ! killer cell lectin-like receptor subfamily B member 1C intersection_of: RO:0002160 NCBITaxon:10090 ! only in taxon Mus musculus [Term] id: PR:P28329 name: choline O-acetyltransferase (human) namespace: protein def: "A choline O-acetyltransferase that is encoded in the genome of human." [PRO:DNx, UniProtKB:P28329] comment: Category=organism-gene. synonym: "CHAT" RELATED Gene-based [UniProtKB:P28329] synonym: "ChAT (human)" EXACT [UniProtKB:P28329] synonym: "CHOACTase (human)" EXACT [UniProtKB:P28329] synonym: "choline acetylase (human)" EXACT [UniProtKB:P28329] synonym: "hCHAT" EXACT PRO-short-label [PRO:DNx] xref: Reactome:R-HSA-264616 "PR:P28329 located_in GO:0005829" xref: UniProtKB:P28329 is_a: PR:000005404 ! choline O-acetyltransferase is_a: PR:000029067 ! Homo sapiens protein intersection_of: PR:000005404 ! choline O-acetyltransferase intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:P28906 name: hematopoietic progenitor cell antigen CD34 (human) namespace: protein def: "A CD34 molecule that is encoded in the genome of human." [] comment: Category=organism-gene. synonym: "CD34" RELATED Gene-based [UniProtKB:P28906] synonym: "hCD34" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:P28906 is_a: PR:000001003 ! CD34 molecule is_a: PR:000029067 ! Homo sapiens protein intersection_of: PR:000001003 ! CD34 molecule intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:P28907 name: ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 (human) namespace: protein def: "An ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 that is encoded in the genome of human." [PRO:WCB, UniProtKB:P28907] comment: Category=organism-gene. synonym: "2'-phospho-ADP-ribosyl cyclase (human)" EXACT [UniProtKB:P28907] synonym: "2'-phospho-ADP-ribosyl cyclase/2'-phospho-cyclic-ADP-ribose transferase (human)" EXACT [UniProtKB:P28907] synonym: "2'-phospho-cyclic-ADP-ribose transferase (human)" EXACT [UniProtKB:P28907] synonym: "ADP-ribosyl cyclase 1 (human)" EXACT [] synonym: "ADPRC 1 (human)" EXACT [UniProtKB:P28907] synonym: "cADPR hydrolase 1 (human)" EXACT [UniProtKB:P28907] synonym: "CD38" RELATED Gene-based [UniProtKB:P28907] synonym: "cyclic ADP-ribose hydrolase 1 (human)" EXACT [UniProtKB:P28907] synonym: "hCD38" EXACT PRO-short-label [PRO:DNx] synonym: "T10 (human)" EXACT [UniProtKB:P28907] xref: Reactome:R-HSA-8938080 "PR:P28907 located_in GO:0005886" xref: UniProtKB:P28907 is_a: PR:000001408 ! ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 is_a: PR:000029067 ! Homo sapiens protein intersection_of: PR:000001408 ! ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:P29017 name: T-cell surface glycoprotein CD1c (human) namespace: protein def: "A T-cell surface glycoprotein CD1c that is encoded in the genome of human." [PRO:WCB, UniProtKB:P29017] comment: Category=organism-gene. synonym: "CD1C" RELATED Gene-based [UniProtKB:P29017] synonym: "CD1c (human)" EXACT [UniProtKB:P29017] synonym: "hCD1C" EXACT PRO-short-label [PRO:DNx] synonym: "human CD1c chain" EXACT [MRO:0000890] xref: MRO:0000890 xref: UniProtKB:P29017 is_a: PR:000002027 ! T-cell surface glycoprotein CD1c is_a: PR:000036947 ! T-cell surface glycoprotein CD1 (human) intersection_of: PR:000002027 ! T-cell surface glycoprotein CD1c intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:P29475 name: nitric oxide synthase 1 (human) namespace: protein def: "A nitric oxide synthase 1 that is encoded in the genome of human." [PRO:DNx, UniProtKB:P29475] comment: Category=organism-gene. synonym: "bNOS (human)" EXACT [UniProtKB:P29475] synonym: "constitutive NOS (human)" BROAD [UniProtKB:P29475] synonym: "hNOS1" EXACT PRO-short-label [PRO:DNx] synonym: "N-NOS (human)" EXACT [UniProtKB:P29475] synonym: "NC-NOS (human)" EXACT [UniProtKB:P29475] synonym: "neuronal NOS (human)" EXACT [UniProtKB:P29475] synonym: "nitric oxide synthase, brain (human)" EXACT [UniProtKB:P29475] synonym: "nNOS (human)" EXACT [UniProtKB:P29475] synonym: "NOS type I (human)" EXACT [UniProtKB:P29475] synonym: "NOS1" RELATED Gene-based [UniProtKB:P29475] synonym: "peptidyl-cysteine S-nitrosylase NOS1 (human)" EXACT [UniProtKB:P29475] xref: Reactome:R-HSA-419293 "PR:P29475 located_in GO:0005829" xref: UniProtKB:P29475 is_a: PR:000011326 ! nitric oxide synthase 1 is_a: PR:000029067 ! Homo sapiens protein intersection_of: PR:000011326 ! nitric oxide synthase 1 intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:P29965 name: CD40 ligand (human) namespace: protein def: "A tumor necrosis factor ligand superfamily member 5 that is encoded in the genome of human." [PRO:WCB, UniProtKB:P29965] comment: Category=organism-gene. synonym: "CD154 (human)" EXACT [UniProtKB:P29965] synonym: "CD40-L (human)" EXACT [UniProtKB:P29965] synonym: "CD40L" RELATED Gene-based [UniProtKB:P29965] synonym: "CD40LG" RELATED Gene-based [UniProtKB:P29965] synonym: "hCD40LG" EXACT PRO-short-label [PRO:DNx] synonym: "T-cell antigen Gp39 (human)" EXACT [UniProtKB:P29965] synonym: "TNF-related activation protein (human)" EXACT [UniProtKB:P29965] synonym: "TNFSF5" RELATED Gene-based [UniProtKB:P29965] synonym: "TRAP" RELATED Gene-based [UniProtKB:P29965] synonym: "tumor necrosis factor ligand superfamily member 5 (human)" EXACT [UniProtKB:P29965] xref: Reactome:R-HSA-198113 "PR:P29965 located_in GO:0005886" xref: UniProtKB:P29965 is_a: PR:000001950 ! tumor necrosis factor ligand superfamily member 5 is_a: PR:000029067 ! Homo sapiens protein intersection_of: PR:000001950 ! tumor necrosis factor ligand superfamily member 5 intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:P30204 name: macrophage scavenger receptor types I and II (mouse) namespace: protein def: "A macrophage scavenger receptor types I and II that is encoded in the genome of mouse." [OMA:P30204, PRO:DNx] comment: Category=organism-gene. synonym: "CD204 (mouse)" EXACT [UniProtKB:P30204] synonym: "macrophage acetylated LDL receptor I and II (mouse)" EXACT [UniProtKB:P30204] synonym: "mMSR1" EXACT PRO-short-label [PRO:DNx] synonym: "Msr1" RELATED Gene-based [UniProtKB:P30204] synonym: "scavenger receptor type A (mouse)" EXACT [UniProtKB:P30204] synonym: "Scvr" RELATED Gene-based [UniProtKB:P30204] synonym: "SR-A (mouse)" EXACT [UniProtKB:P30204] xref: UniProtKB:P30204 is_a: PR:000001885 ! macrophage scavenger receptor types I and II is_a: PR:000029032 ! Mus musculus protein intersection_of: PR:000001885 ! macrophage scavenger receptor types I and II intersection_of: RO:0002160 NCBITaxon:10090 ! only in taxon Mus musculus [Term] id: PR:P30530 name: tyrosine-protein kinase receptor UFO (human) namespace: protein def: "A tyrosine-protein kinase receptor UFO that is encoded in the genome of human." [PRO:DNx, UniProtKB:P30530] comment: Category=organism-gene. synonym: "AXL" RELATED Gene-based [UniProtKB:P30530] synonym: "AXL oncogene (human)" EXACT [UniProtKB:P30530] synonym: "hAXL" EXACT PRO-short-label [PRO:DNx] synonym: "UFO" RELATED Gene-based [UniProtKB:P30530] xref: DTO:03100553 xref: UniProtKB:P30530 is_a: PR:000004528 ! tyrosine-protein kinase receptor UFO is_a: PR:000029067 ! Homo sapiens protein intersection_of: PR:000004528 ! tyrosine-protein kinase receptor UFO intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:P30559 name: oxytocin receptor (human) namespace: protein def: "An oxytocin receptor that is encoded in the genome of human." [PRO:WCB, UniProtKB:P30559] comment: Category=organism-gene. Requested by=PubChem. synonym: "hOXTR" EXACT PRO-short-label [PRO:DNx] synonym: "OT-R (human)" EXACT [UniProtKB:P30559] synonym: "OXTR" RELATED Gene-based [UniProtKB:P30559] xref: DTO:02100725 xref: Reactome:R-HSA-388428 "PR:P30559 located_in GO:0005886" xref: UniProtKB:P30559 is_a: PR:000001635 ! oxytocin receptor is_a: PR:000029067 ! Homo sapiens protein intersection_of: PR:000001635 ! oxytocin receptor intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:P31041 name: T-cell-specific surface glycoprotein CD28 (mouse) namespace: protein def: "A T-cell-specific surface glycoprotein CD28 that is encoded in the genome of mouse." [OMA:P31041, PRO:DNx] comment: Category=organism-gene. synonym: "Cd28" RELATED Gene-based [UniProtKB:P31041] synonym: "CD28 (mouse)" EXACT [UniProtKB:P31041] synonym: "mCD28" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:P31041 is_a: PR:000001841 ! T-cell-specific surface glycoprotein CD28 is_a: PR:000029032 ! Mus musculus protein intersection_of: PR:000001841 ! T-cell-specific surface glycoprotein CD28 intersection_of: RO:0002160 NCBITaxon:10090 ! only in taxon Mus musculus [Term] id: PR:P31428 name: dipeptidase 1 (mouse) namespace: protein def: "A dipeptidase 1 that is encoded in the genome of mouse." [OMA:P31428, PRO:DNx] comment: Category=organism-gene. synonym: "beta-lactamase (mouse)" EXACT [UniProtKB:P31428] synonym: "DPEP-1 (mouse)" EXACT [UniProtKB:P31428] synonym: "Dpep1" RELATED Gene-based [UniProtKB:P31428] synonym: "MBD-1 (mouse)" EXACT [UniProtKB:P31428] synonym: "Mbd1" RELATED Gene-based [UniProtKB:P31428] synonym: "mDPEP1" EXACT PRO-short-label [PRO:DNx] synonym: "membrane-bound dipeptidase 1 (mouse)" EXACT [UniProtKB:P31428] synonym: "microsomal dipeptidase (mouse)" EXACT [UniProtKB:P31428] synonym: "Rdp" RELATED Gene-based [UniProtKB:P31428] synonym: "renal dipeptidase (mouse)" EXACT [UniProtKB:P31428] xref: UniProtKB:P31428 is_a: PR:000006646 ! dipeptidase 1 is_a: PR:000029032 ! Mus musculus protein intersection_of: PR:000006646 ! dipeptidase 1 intersection_of: RO:0002160 NCBITaxon:10090 ! only in taxon Mus musculus [Term] id: PR:P31994 name: low affinity immunoglobulin gamma Fc region receptor II-b (human) namespace: protein def: "A low affinity immunoglobulin gamma Fc region receptor II-b that is encoded in the genome of human." [PRO:CNA, UniProtKB:P31994] comment: Category=organism-gene. synonym: "CD32" RELATED Gene-based [UniProtKB:P31994] synonym: "CD32 (human)" BROAD [UniProtKB:P31994] synonym: "CDw32 (human)" BROAD [UniProtKB:P31994] synonym: "Fc-gamma RII-b (human)" EXACT [UniProtKB:P31994] synonym: "Fc-gamma-RIIb (human)" EXACT [UniProtKB:P31994] synonym: "FCG2" RELATED Gene-based [UniProtKB:P31994] synonym: "FCGR2B" RELATED Gene-based [UniProtKB:P31994] synonym: "FcRII-b (human)" EXACT [UniProtKB:P31994] synonym: "hFCGR2B" EXACT PRO-short-label [PRO:DNx] synonym: "IGFR2" RELATED Gene-based [UniProtKB:P31994] synonym: "IgG Fc receptor II-b (human)" EXACT [UniProtKB:P31994] xref: UniProtKB:P31994 is_a: PR:000001481 ! low affinity immunoglobulin gamma Fc region receptor II-b is_a: PR:000029067 ! Homo sapiens protein intersection_of: PR:000001481 ! low affinity immunoglobulin gamma Fc region receptor II-b intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:P31996 name: macrosialin (mouse) namespace: protein def: "A macrosialin that is encoded in the genome of mouse." [OMA:P31996, PRO:DNx] comment: Category=organism-gene. synonym: "Cd68" RELATED Gene-based [UniProtKB:P31996] synonym: "CD68 (mouse)" EXACT [UniProtKB:P31996] synonym: "mCD68" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:P31996 is_a: PR:000002064 ! macrosialin is_a: PR:000029032 ! Mus musculus protein intersection_of: PR:000002064 ! macrosialin intersection_of: RO:0002160 NCBITaxon:10090 ! only in taxon Mus musculus [Term] id: PR:P31997 name: cell adhesion molecule CEACAM8 (human) namespace: protein def: "A cell adhesion molecule CEACAM8 that is encoded in the genome of human." [PRO:CNA, UniProtKB:P31997] comment: Category=organism-gene. synonym: "carcinoembryonic antigen CGM6 (human)" EXACT [UniProtKB:P31997] synonym: "carcinoembryonic antigen-related cell adhesion molecule 8 (human)" EXACT [UniProtKB:P31997] synonym: "CD66b (human)" EXACT [UniProtKB:P31997] synonym: "CD67 antigen (human)" EXACT [UniProtKB:P31997] synonym: "CEA cell adhesion molecule 8 (human)" EXACT [UniProtKB:P31997] synonym: "CEACAM8" RELATED Gene-based [UniProtKB:P31997] synonym: "CGM6" RELATED Gene-based [UniProtKB:P31997] synonym: "hCEACAM8" EXACT PRO-short-label [PRO:DNx] synonym: "non-specific cross-reacting antigen NCA-95 (human)" EXACT [UniProtKB:P31997] xref: UniProtKB:P31997 is_a: PR:000001332 ! cell adhesion molecule CEACAM8 is_a: PR:000029067 ! Homo sapiens protein intersection_of: PR:000001332 ! cell adhesion molecule CEACAM8 intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:P32246 name: C-C chemokine receptor type 1 (human) namespace: protein def: "A C-C chemokine receptor type 1 that is encoded in the genome of human." [PRO:WCB, UniProtKB:P32246] comment: Category=organism-gene. synonym: "C-C CKR-1 (human)" EXACT [UniProtKB:P32246] synonym: "CC-CKR-1 (human)" EXACT [UniProtKB:P32246] synonym: "CCR-1 (human)" EXACT [UniProtKB:P32246] synonym: "CCR1" RELATED Gene-based [UniProtKB:P32246] synonym: "CD191 (human)" EXACT [UniProtKB:P32246] synonym: "CMKBR1" RELATED Gene-based [UniProtKB:P32246] synonym: "CMKR1" RELATED Gene-based [UniProtKB:P32246] synonym: "hCCR1" EXACT PRO-short-label [PRO:DNx] synonym: "HM145 (human)" EXACT [UniProtKB:P32246] synonym: "LD78 receptor (human)" EXACT [UniProtKB:P32246] synonym: "macrophage inflammatory protein 1-alpha receptor (human)" EXACT [UniProtKB:P32246] synonym: "MIP-1alpha-R (human)" EXACT [UniProtKB:P32246] synonym: "RANTES-R (human)" EXACT [UniProtKB:P32246] synonym: "SCYAR1" RELATED Gene-based [UniProtKB:P32246] xref: DTO:02100053 xref: Reactome:R-HSA-373107 "PR:P32246 located_in GO:0005886" xref: UniProtKB:P32246 is_a: PR:000001254 ! C-C chemokine receptor type 1 is_a: PR:000029067 ! Homo sapiens protein intersection_of: PR:000001254 ! C-C chemokine receptor type 1 intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:P32248 name: C-C chemokine receptor type 7 (human) namespace: protein def: "A C-C chemokine receptor type 7 that is encoded in the genome of human." [PRO:WCB, UniProtKB:P32248] comment: Category=organism-gene. synonym: "BLR2 (human)" EXACT [UniProtKB:P32248] synonym: "C-C CKR-7 (human)" EXACT [UniProtKB:P32248] synonym: "CC-CKR-7 (human)" EXACT [UniProtKB:P32248] synonym: "CCR-7 (human)" EXACT [UniProtKB:P32248] synonym: "CCR7" RELATED Gene-based [UniProtKB:P32248] synonym: "CD197 (human)" EXACT [UniProtKB:P32248] synonym: "CDw197 (human)" EXACT [UniProtKB:P32248] synonym: "CMKBR7" RELATED Gene-based [UniProtKB:P32248] synonym: "EBI1" RELATED Gene-based [UniProtKB:P32248] synonym: "EBV-induced G-protein coupled receptor 1 (human)" EXACT [UniProtKB:P32248] synonym: "epstein-Barr virus-induced G-protein coupled receptor 1 (human)" EXACT [UniProtKB:P32248] synonym: "EVI1" RELATED Gene-based [UniProtKB:P32248] synonym: "hCCR7" EXACT PRO-short-label [PRO:DNx] synonym: "MIP-3 beta receptor (human)" EXACT [UniProtKB:P32248] xref: DTO:02100059 xref: UniProtKB:P32248 is_a: PR:000001203 ! C-C chemokine receptor type 7 is_a: PR:000029067 ! Homo sapiens protein intersection_of: PR:000001203 ! C-C chemokine receptor type 7 intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:P32302 name: C-X-C chemokine receptor type 5 (human) namespace: protein def: "A C-X-C chemokine receptor type 5 that is encoded in the genome of human." [PRO:WCB, UniProtKB:P32302] comment: Category=organism-gene. synonym: "BLR1" RELATED Gene-based [UniProtKB:P32302] synonym: "burkitt lymphoma receptor 1 (human)" EXACT [UniProtKB:P32302] synonym: "CD185 (human)" EXACT [UniProtKB:P32302] synonym: "CXC-R5 (human)" EXACT [UniProtKB:P32302] synonym: "CXCR-5 (human)" EXACT [UniProtKB:P32302] synonym: "CXCR5" RELATED Gene-based [UniProtKB:P32302] synonym: "hCXCR5" EXACT PRO-short-label [PRO:DNx] synonym: "MDR-15 (human)" EXACT [UniProtKB:P32302] synonym: "MDR15" RELATED Gene-based [UniProtKB:P32302] synonym: "monocyte-derived receptor 15 (human)" EXACT [UniProtKB:P32302] xref: DTO:02100079 xref: Reactome:R-HSA-444505 "PR:P32302 located_in GO:0005886" xref: UniProtKB:P32302 is_a: PR:000001209 ! C-X-C chemokine receptor type 5 is_a: PR:000029067 ! Homo sapiens protein intersection_of: PR:000001209 ! C-X-C chemokine receptor type 5 intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:P32648 name: VIP peptides (mouse) namespace: protein def: "A VIP peptides that is encoded in the genome of mouse." [OMA:P32648, PRO:DNx] comment: Category=organism-gene. synonym: "mVIP" EXACT PRO-short-label [PRO:DNx] synonym: "Vip" RELATED Gene-based [UniProtKB:P32648] xref: UniProtKB:P32648 is_a: PR:000017299 ! VIP peptides is_a: PR:000029032 ! Mus musculus protein intersection_of: PR:000017299 ! VIP peptides intersection_of: RO:0002160 NCBITaxon:10090 ! only in taxon Mus musculus [Term] id: PR:P32848 name: parvalbumin alpha (mouse) namespace: protein def: "A parvalbumin alpha that is encoded in the genome of mouse." [OMA:P32848, PRO:DNx] comment: Category=organism-gene. synonym: "alpha-parvalbumin (mouse)" EXACT [UniProtKB:P32848] synonym: "alpha-PV (mouse)" EXACT [UniProtKB:P32848] synonym: "mPVALB" EXACT PRO-short-label [PRO:DNx] synonym: "Pva" RELATED Gene-based [UniProtKB:P32848] synonym: "Pvalb" RELATED Gene-based [UniProtKB:P32848] xref: UniProtKB:P32848 is_a: PR:000013502 ! parvalbumin alpha is_a: PR:000029032 ! Mus musculus protein intersection_of: PR:000013502 ! parvalbumin alpha intersection_of: RO:0002160 NCBITaxon:10090 ! only in taxon Mus musculus [Term] id: PR:P33151 name: cadherin-5 (human) namespace: protein def: "A cadherin-5 that is encoded in the genome of human." [PRO:WCB, UniProtKB:P33151] comment: Category=organism-gene. synonym: "7B4 antigen (human)" EXACT [UniProtKB:P33151] synonym: "CD144 (human)" EXACT [UniProtKB:P33151] synonym: "CDH5" RELATED Gene-based [UniProtKB:P33151] synonym: "hCDH5" EXACT PRO-short-label [PRO:DNx] synonym: "vascular endothelial cadherin (human)" EXACT [UniProtKB:P33151] synonym: "VE-cadherin (human)" EXACT [UniProtKB:P33151] xref: UniProtKB:P33151 is_a: PR:000001444 ! cadherin-5 is_a: PR:000029067 ! Homo sapiens protein intersection_of: PR:000001444 ! cadherin-5 intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:P33681 name: T-lymphocyte activation antigen CD80 (human) namespace: protein def: "A CD80 molecule that is encoded in the genome of human." [PRO:WCB, UniProtKB:P33681] comment: Category=organism-gene. synonym: "activation B7-1 antigen (human)" EXACT [UniProtKB:P33681] synonym: "B7 (human)" EXACT [UniProtKB:P33681] synonym: "BB1 (human)" EXACT [UniProtKB:P33681] synonym: "CD28LG" RELATED Gene-based [UniProtKB:P33681] synonym: "CD28LG1" RELATED Gene-based [UniProtKB:P33681] synonym: "CD80" RELATED Gene-based [UniProtKB:P33681] synonym: "CTLA-4 counter-receptor B7.1 (human)" EXACT [UniProtKB:P33681] synonym: "hCD80" EXACT PRO-short-label [PRO:DNx] synonym: "LAB7" RELATED Gene-based [UniProtKB:P33681] xref: UniProtKB:P33681 is_a: PR:000001438 ! CD80 molecule is_a: PR:000029067 ! Homo sapiens protein intersection_of: PR:000001438 ! CD80 molecule intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:P33766 name: fMet-Leu-Phe receptor (mouse) namespace: protein def: "An fMet-Leu-Phe receptor that is encoded in the genome of mouse." [OMA:P33766, PRO:DNx] comment: Category=organism-gene. synonym: "fMLP receptor (mouse)" EXACT [UniProtKB:P33766] synonym: "FPR (mouse)" EXACT [UniProtKB:P33766] synonym: "Fpr1" RELATED Gene-based [UniProtKB:P33766] synonym: "mFPR1" EXACT PRO-short-label [PRO:DNx] synonym: "N-formyl peptide receptor (mouse)" EXACT [UniProtKB:P33766] synonym: "N-formylpeptide chemoattractant receptor (mouse)" EXACT [UniProtKB:P33766] xref: UniProtKB:P33766 is_a: PR:000001580 ! fMet-Leu-Phe receptor is_a: PR:000029032 ! Mus musculus protein intersection_of: PR:000001580 ! fMet-Leu-Phe receptor intersection_of: RO:0002160 NCBITaxon:10090 ! only in taxon Mus musculus [Term] id: PR:P34810 name: macrosialin (human) namespace: protein def: "A macrosialin that is encoded in the genome of human." [PRO:WCB, UniProtKB:P34810] comment: Category=organism-gene. synonym: "CD68" RELATED Gene-based [UniProtKB:P34810] synonym: "gp110 (human)" BROAD [UniProtKB:P34810] synonym: "hCD68" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:P34810 is_a: PR:000002064 ! macrosialin is_a: PR:000029067 ! Homo sapiens protein intersection_of: PR:000002064 ! macrosialin intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:P35329 name: B-cell receptor CD22 (mouse) namespace: protein def: "A B-cell receptor CD22 that is encoded in the genome of mouse." [OMA:P35329, PRO:DNx] comment: Category=organism-gene. synonym: "B-lymphocyte cell adhesion molecule (mouse)" EXACT [UniProtKB:P35329] synonym: "BL-CAM (mouse)" EXACT [UniProtKB:P35329] synonym: "Cd22" RELATED Gene-based [UniProtKB:P35329] synonym: "CD22 (mouse)" EXACT [UniProtKB:P35329] synonym: "Lyb-8" RELATED Gene-based [UniProtKB:P35329] synonym: "mCD22" EXACT PRO-short-label [PRO:DNx] synonym: "sialic acid-binding Ig-like lectin 2 (mouse)" EXACT [UniProtKB:P35329] synonym: "siglec-2 (mouse)" EXACT [UniProtKB:P35329] synonym: "Siglec2" RELATED Gene-based [UniProtKB:P35329] synonym: "T-cell surface antigen Leu-14 (mouse)" EXACT [UniProtKB:P35329] xref: UniProtKB:P35329 is_a: PR:000001288 ! B-cell receptor CD22 is_a: PR:000029032 ! Mus musculus protein intersection_of: PR:000001288 ! B-cell receptor CD22 intersection_of: RO:0002160 NCBITaxon:10090 ! only in taxon Mus musculus [Term] id: PR:P35343 name: C-X-C chemokine receptor type 2 (mouse) namespace: protein def: "A C-X-C chemokine receptor type 2 that is encoded in the genome of mouse." [PRO:WCB] comment: Category=organism-gene. synonym: "CD182 (mouse)" EXACT [UniProtKB:P35343] synonym: "Cmkar2" RELATED Gene-based [UniProtKB:P35343] synonym: "CXC-R2 (mouse)" EXACT [UniProtKB:P35343] synonym: "CXCR-2 (mouse)" EXACT [UniProtKB:P35343] synonym: "Cxcr2" RELATED Gene-based [UniProtKB:P35343] synonym: "Gpcr16" RELATED Gene-based [UniProtKB:P35343] synonym: "GRO/MGSA receptor (mouse)" EXACT [UniProtKB:P35343] synonym: "high affinity interleukin-8 receptor B (mouse)" EXACT [UniProtKB:P35343] synonym: "IL-8R B (mouse)" EXACT [UniProtKB:P35343] synonym: "Il8rb" RELATED Gene-based [UniProtKB:P35343] synonym: "mCXCR2" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:P35343 is_a: PR:000001257 ! C-X-C chemokine receptor type 2 is_a: PR:000029032 ! Mus musculus protein intersection_of: PR:000001257 ! C-X-C chemokine receptor type 2 intersection_of: RO:0002160 NCBITaxon:10090 ! only in taxon Mus musculus [Term] id: PR:P35456 name: urokinase plasminogen activator surface receptor (mouse) namespace: protein def: "A urokinase plasminogen activator surface receptor that is encoded in the genome of mouse." [OMA:P35456, PRO:DNx] comment: Category=organism-gene. synonym: "CD87 (mouse)" EXACT [UniProtKB:P35456] synonym: "mPLAUR" EXACT PRO-short-label [PRO:DNx] synonym: "Plaur" RELATED Gene-based [UniProtKB:P35456] synonym: "U-PAR (mouse)" EXACT [UniProtKB:P35456] synonym: "uPAR (mouse)" EXACT [UniProtKB:P35456] xref: UniProtKB:P35456 is_a: PR:000001969 ! urokinase plasminogen activator surface receptor is_a: PR:000029032 ! Mus musculus protein intersection_of: PR:000001969 ! urokinase plasminogen activator surface receptor intersection_of: RO:0002160 NCBITaxon:10090 ! only in taxon Mus musculus [Term] id: PR:P35461 name: lymphocyte antigen 6G (mouse) namespace: protein def: "A lymphocyte antigen 6G that is encoded in the genome of mouse." [PRO:CNA, UniProtKB:P35461] comment: Category=organism-gene. synonym: "Ly-6G (mouse)" EXACT [UniProtKB:P35461] synonym: "Ly-6G.1 (mouse)" EXACT [UniProtKB:P35461] synonym: "Ly6g" RELATED Gene-based [UniProtKB:P35461] synonym: "mLy6g" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:P35461 is_a: PR:000002978 ! lymphocyte antigen 6G is_a: PR:000029032 ! Mus musculus protein intersection_of: PR:000002978 ! lymphocyte antigen 6G intersection_of: RO:0002160 NCBITaxon:10090 ! only in taxon Mus musculus [Term] id: PR:P35546 name: proto-oncogene tyrosine-protein kinase receptor Ret (mouse) namespace: protein def: "A proto-oncogene tyrosine-protein kinase receptor Ret that is encoded in the genome of mouse." [OMA:P35546, PRO:DNx] comment: Category=organism-gene. synonym: "mRET" EXACT PRO-short-label [PRO:DNx] synonym: "proto-oncogene c-Ret (mouse)" EXACT [UniProtKB:P35546] synonym: "Ret" RELATED Gene-based [UniProtKB:P35546] xref: UniProtKB:P35546 is_a: PR:000013895 ! proto-oncogene tyrosine-protein kinase receptor Ret is_a: PR:000029032 ! Mus musculus protein intersection_of: PR:000013895 ! proto-oncogene tyrosine-protein kinase receptor Ret intersection_of: RO:0002160 NCBITaxon:10090 ! only in taxon Mus musculus [Term] id: PR:P35918 name: vascular endothelial growth factor receptor 2 (mouse) namespace: protein def: "A vascular endothelial growth factor receptor 2 that is encoded in the genome of mouse." [OMA:P35918, PRO:DNx] comment: Category=organism-gene. synonym: "CD309 (mouse)" EXACT [UniProtKB:P35918] synonym: "fetal liver kinase 1 (mouse)" EXACT [UniProtKB:P35918] synonym: "Flk-1" RELATED Gene-based [UniProtKB:P35918] synonym: "FLK-1 (mouse)" EXACT [UniProtKB:P35918] synonym: "Flk1" RELATED Gene-based [UniProtKB:P35918] synonym: "Kdr" RELATED Gene-based [UniProtKB:P35918] synonym: "kinase NYK (mouse)" EXACT [UniProtKB:P35918] synonym: "mKDR" EXACT PRO-short-label [PRO:DNx] synonym: "protein-tyrosine kinase receptor flk-1 (mouse)" EXACT [UniProtKB:P35918] synonym: "VEGFR-2 (mouse)" EXACT [UniProtKB:P35918] xref: UniProtKB:P35918 is_a: PR:000002112 ! vascular endothelial growth factor receptor 2 is_a: PR:000029032 ! Mus musculus protein intersection_of: PR:000002112 ! vascular endothelial growth factor receptor 2 intersection_of: RO:0002160 NCBITaxon:10090 ! only in taxon Mus musculus [Term] id: PR:P35968 name: vascular endothelial growth factor receptor 2 (human) namespace: protein def: "A vascular endothelial growth factor receptor 2 that is encoded in the genome of human." [PRO:WCB, UniProtKB:P35968] comment: Category=organism-gene. synonym: "CD309 (human)" EXACT [UniProtKB:P35968] synonym: "fetal liver kinase 1 (human)" EXACT [UniProtKB:P35968] synonym: "FLK-1 (human)" EXACT [UniProtKB:P35968] synonym: "FLK1" RELATED Gene-based [UniProtKB:P35968] synonym: "hKDR" EXACT PRO-short-label [PRO:DNx] synonym: "KDR" RELATED Gene-based [UniProtKB:P35968] synonym: "kinase insert domain receptor (human)" EXACT [UniProtKB:P35968] synonym: "protein-tyrosine kinase receptor flk-1 (human)" EXACT [UniProtKB:P35968] synonym: "VEGFR-2 (human)" EXACT [UniProtKB:P35968] synonym: "VEGFR2" RELATED Gene-based [UniProtKB:P35968] xref: DTO:03100560 xref: UniProtKB:P35968 is_a: PR:000002112 ! vascular endothelial growth factor receptor 2 is_a: PR:000029067 ! Homo sapiens protein intersection_of: PR:000002112 ! vascular endothelial growth factor receptor 2 intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:P36363 name: fibroblast growth factor 7 (mouse) namespace: protein def: "A fibroblast growth factor 7 that is encoded in the genome of mouse." [OMA:P36363, PRO:DNx] comment: Category=organism-gene. synonym: "Fgf-7" RELATED Gene-based [UniProtKB:P36363] synonym: "FGF-7 (mouse)" EXACT [UniProtKB:P36363] synonym: "Fgf7" RELATED Gene-based [UniProtKB:P36363] synonym: "HBGF-7 (mouse)" EXACT [UniProtKB:P36363] synonym: "heparin-binding growth factor 7 (mouse)" EXACT [UniProtKB:P36363] synonym: "keratinocyte growth factor (mouse)" EXACT [UniProtKB:P36363] synonym: "Kgf" RELATED Gene-based [UniProtKB:P36363] synonym: "KGF (mouse)" EXACT [UniProtKB:P36363] synonym: "mFGF7" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:P36363 is_a: PR:000007498 ! fibroblast growth factor 7 is_a: PR:000029032 ! Mus musculus protein intersection_of: PR:000007498 ! fibroblast growth factor 7 intersection_of: RO:0002160 NCBITaxon:10090 ! only in taxon Mus musculus [Term] id: PR:P36544 name: neuronal acetylcholine receptor subunit alpha-7 (human) namespace: protein def: "A neuronal acetylcholine receptor subunit alpha-7 that is encoded in the genome of human." [PRO:DNx, UniProtKB:P36544] comment: Category=organism-gene. synonym: "CHRNA7" RELATED Gene-based [UniProtKB:P36544] synonym: "hCHRNA7" EXACT PRO-short-label [PRO:DNx] synonym: "nAChR7 (human)" EXACT [UniProtKB:P36544] synonym: "NACHRA7" RELATED Gene-based [UniProtKB:P36544] synonym: "nicotinic acetylcholine receptor subunit alpha-7 (human)" EXACT [UniProtKB:P36544] xref: DTO:01100012 xref: UniProtKB:P36544 is_a: PR:000005460 ! neuronal acetylcholine receptor subunit alpha-7 is_a: PR:000029067 ! Homo sapiens protein intersection_of: PR:000005460 ! neuronal acetylcholine receptor subunit alpha-7 intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:P36888 name: receptor-type tyrosine-protein kinase FLT3 (human) namespace: protein def: "A receptor-type tyrosine-protein kinase FLT3 that is encoded in the genome of human." [PRO:WCB, UniProtKB:P36888] comment: Category=organism-gene. synonym: "CD135" RELATED Gene-based [UniProtKB:P36888] synonym: "fetal liver kinase-2 (human)" EXACT [UniProtKB:P36888] synonym: "FL cytokine receptor (human)" EXACT [UniProtKB:P36888] synonym: "FLK-2 (human)" EXACT [UniProtKB:P36888] synonym: "FLK2" RELATED Gene-based [UniProtKB:P36888] synonym: "FLT-3 (human)" EXACT [UniProtKB:P36888] synonym: "FLT3" RELATED Gene-based [UniProtKB:P36888] synonym: "fms-like tyrosine kinase 3 (human)" EXACT [UniProtKB:P36888] synonym: "hFLT3" EXACT PRO-short-label [PRO:DNx] synonym: "Stem cell tyrosine kinase 1 (human)" EXACT [UniProtKB:P36888] synonym: "STK-1 (human)" BROAD [UniProtKB:P36888] synonym: "STK1" RELATED Gene-based [UniProtKB:P36888] xref: DTO:03100154 xref: UniProtKB:P36888 is_a: PR:000002001 ! receptor-type tyrosine-protein kinase FLT3 is_a: PR:000029067 ! Homo sapiens protein intersection_of: PR:000002001 ! receptor-type tyrosine-protein kinase FLT3 intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:P37217 name: early activation antigen CD69 (mouse) namespace: protein def: "A CD69 molecule that is encoded in the genome of mouse." [OMA:P37217, PRO:DNx] comment: Category=organism-gene. synonym: "Cd69" RELATED Gene-based [UniProtKB:P37217] synonym: "CD69 (mouse)" EXACT [UniProtKB:P37217] synonym: "mCD69" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:P37217 is_a: PR:000001343 ! CD69 molecule is_a: PR:000029032 ! Mus musculus protein intersection_of: PR:000001343 ! CD69 molecule intersection_of: RO:0002160 NCBITaxon:10090 ! only in taxon Mus musculus [Term] id: PR:P37237 name: fibroblast growth factor 8 (mouse) namespace: protein def: "A fibroblast growth factor 8 that is encoded in the genome of mouse." [OMA:P37237, PRO:DNx] comment: Category=organism-gene. synonym: "Aigf" RELATED Gene-based [UniProtKB:P37237] synonym: "AIGF (mouse)" EXACT [UniProtKB:P37237] synonym: "androgen-induced growth factor (mouse)" EXACT [UniProtKB:P37237] synonym: "FGF-8 (mouse)" EXACT [UniProtKB:P37237] synonym: "Fgf8" RELATED Gene-based [UniProtKB:P37237] synonym: "HBGF-8 (mouse)" RELATED [UniProtKB:P37237] synonym: "heparin-binding growth factor 8 (mouse)" RELATED [UniProtKB:P37237] synonym: "mFGF8" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:P37237 is_a: PR:000007499 ! fibroblast growth factor 8 is_a: PR:000029032 ! Mus musculus protein intersection_of: PR:000007499 ! fibroblast growth factor 8 intersection_of: RO:0002160 NCBITaxon:10090 ! only in taxon Mus musculus [Term] id: PR:P38570 name: integrin alpha-E (human) namespace: protein def: "An integrin alpha-E that is encoded in the genome of human." [PRO:CNA, UniProtKB:P38570] comment: Category=organism-gene. synonym: "CD103 (human)" EXACT [UniProtKB:P38570] synonym: "hITGAE" EXACT PRO-short-label [PRO:DNx] synonym: "HML-1 antigen (human)" EXACT [UniProtKB:P38570] synonym: "integrin alpha-IEL (human)" EXACT [UniProtKB:P38570] synonym: "ITGAE" RELATED Gene-based [UniProtKB:P38570] synonym: "mucosal lymphocyte 1 antigen (human)" EXACT [UniProtKB:P38570] xref: UniProtKB:P38570 is_a: PR:000001010 ! integrin alpha-E is_a: PR:000029067 ! Homo sapiens protein intersection_of: PR:000001010 ! integrin alpha-E intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:P40240 name: CD9 antigen (mouse) namespace: protein def: "A CD9 molecule that is encoded in the genome of mouse." [OMA:P40240, PRO:DNx] comment: Category=organism-gene. synonym: "Cd9" RELATED Gene-based [UniProtKB:P40240] synonym: "CD9 (mouse)" EXACT [UniProtKB:P40240] synonym: "mCD9" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:P40240 is_a: PR:000005178 ! CD9 molecule is_a: PR:000029032 ! Mus musculus protein intersection_of: PR:000005178 ! CD9 molecule intersection_of: RO:0002160 NCBITaxon:10090 ! only in taxon Mus musculus [Term] id: PR:P41182 name: B-cell lymphoma 6 protein (human) namespace: protein def: "A B-cell lymphoma 6 protein that is encoded in the genome of human." [PRO:CNA, UniProtKB:P41182] comment: Category=organism-gene. synonym: "B-cell lymphoma 5 protein (human)" EXACT [UniProtKB:P41182] synonym: "BCL-5 (human)" EXACT [UniProtKB:P41182] synonym: "BCL-6 (human)" EXACT [UniProtKB:P41182] synonym: "BCL5" RELATED Gene-based [UniProtKB:P41182] synonym: "BCL6" RELATED Gene-based [UniProtKB:P41182] synonym: "hBCL6" EXACT PRO-short-label [PRO:DNx] synonym: "LAZ3" RELATED Gene-based [UniProtKB:P41182] synonym: "protein LAZ-3 (human)" EXACT [UniProtKB:P41182] synonym: "ZBTB27" RELATED Gene-based [UniProtKB:P41182] synonym: "zinc finger and BTB domain-containing protein 27 (human)" EXACT [UniProtKB:P41182] synonym: "zinc finger protein 51 (human)" EXACT [UniProtKB:P41182] synonym: "ZNF51" RELATED Gene-based [UniProtKB:P41182] xref: Reactome:R-HSA-5223066 "PR:P41182 located_in GO:0005654" xref: UniProtKB:P41182 is_a: PR:000003450 ! B-cell lymphoma 6 protein is_a: PR:000029067 ! Homo sapiens protein intersection_of: PR:000003450 ! B-cell lymphoma 6 protein intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:P41183 name: B-cell lymphoma 6 protein homolog (mouse) namespace: protein def: "A B-cell lymphoma 6 protein that is encoded in the genome of mouse." [OMA:P41183, PRO:DNx] comment: Category=organism-gene. synonym: "Bcl-6" RELATED Gene-based [UniProtKB:P41183] synonym: "Bcl6" RELATED Gene-based [UniProtKB:P41183] synonym: "mBCL6" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:P41183 is_a: PR:000003450 ! B-cell lymphoma 6 protein is_a: PR:000029032 ! Mus musculus protein intersection_of: PR:000003450 ! B-cell lymphoma 6 protein intersection_of: RO:0002160 NCBITaxon:10090 ! only in taxon Mus musculus [Term] id: PR:P41219 name: peripherin (human) namespace: protein def: "A peripherin that is encoded in the genome of human." [PRO:DNx, UniProtKB:P41219] comment: Category=organism-gene. synonym: "hPRPH" EXACT PRO-short-label [PRO:DNx] synonym: "NEF4" RELATED Gene-based [UniProtKB:P41219] synonym: "neurofilament 4 (human)" EXACT [UniProtKB:P41219] synonym: "PRPH" RELATED Gene-based [UniProtKB:P41219] synonym: "PRPH1" RELATED Gene-based [UniProtKB:P41219] xref: UniProtKB:P41219 is_a: PR:000013289 ! peripherin is_a: PR:000029067 ! Homo sapiens protein intersection_of: PR:000013289 ! peripherin intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:P41272 name: CD27 antigen (mouse) namespace: protein def: "A CD27 molecule that is encoded in the genome of mouse." [OMA:P41272, PRO:DNx] comment: Category=organism-gene. synonym: "Cd27" RELATED Gene-based [UniProtKB:P41272] synonym: "CD27 (mouse)" EXACT [UniProtKB:P41272] synonym: "CD27L receptor (mouse)" EXACT [UniProtKB:P41272] synonym: "mCD27" EXACT PRO-short-label [PRO:DNx] synonym: "T-cell activation antigen CD27 (mouse)" EXACT [UniProtKB:P41272] synonym: "Tnfrsf7" RELATED Gene-based [UniProtKB:P41272] synonym: "tumor necrosis factor receptor superfamily member 7 (mouse)" EXACT [UniProtKB:P41272] xref: UniProtKB:P41272 is_a: PR:000001963 ! CD27 molecule is_a: PR:000029032 ! Mus musculus protein intersection_of: PR:000001963 ! CD27 molecule intersection_of: RO:0002160 NCBITaxon:10090 ! only in taxon Mus musculus [Term] id: PR:P41597 name: C-C chemokine receptor type 2 (human) namespace: protein def: "A C-C chemokine receptor type 2 that is encoded in the genome of human." [PRO:WCB, UniProtKB:P41597] comment: Category=organism-gene. synonym: "C-C CKR-2 (human)" EXACT [UniProtKB:P41597] synonym: "CC-CKR-2 (human)" EXACT [UniProtKB:P41597] synonym: "CCR-2 (human)" EXACT [UniProtKB:P41597] synonym: "CCR2" RELATED Gene-based [UniProtKB:P41597] synonym: "CD192 (human)" EXACT [UniProtKB:P41597] synonym: "CMKBR2" RELATED Gene-based [UniProtKB:P41597] synonym: "hCCR2" EXACT PRO-short-label [PRO:DNx] synonym: "MCP-1-R (human)" EXACT [UniProtKB:P41597] synonym: "monocyte chemoattractant protein 1 receptor (human)" EXACT [UniProtKB:P41597] xref: DTO:02100054 xref: Reactome:R-HSA-2976755 "PR:P41597 located_in GO:0005886" xref: UniProtKB:P41597 is_a: PR:000001199 ! C-C chemokine receptor type 2 is_a: PR:000029067 ! Homo sapiens protein intersection_of: PR:000001199 ! C-C chemokine receptor type 2 intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:P42081 name: T-lymphocyte activation antigen CD86 (human) namespace: protein def: "A CD86 molecule that is encoded in the genome of human." [PRO:WCB, UniProtKB:P42081] comment: Category=organism-gene. synonym: "activation B7-2 antigen (human)" EXACT [UniProtKB:P42081] synonym: "B70 (human)" EXACT [UniProtKB:P42081] synonym: "BU63 (human)" EXACT [UniProtKB:P42081] synonym: "CD28LG2" RELATED Gene-based [UniProtKB:P42081] synonym: "CD86" RELATED Gene-based [UniProtKB:P42081] synonym: "CTLA-4 counter-receptor B7.2 (human)" EXACT [UniProtKB:P42081] synonym: "FUN-1 (human)" EXACT [UniProtKB:P42081] synonym: "hCD86" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:P42081 is_a: PR:000001412 ! CD86 molecule is_a: PR:000029067 ! Homo sapiens protein intersection_of: PR:000001412 ! CD86 molecule intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:P42082 name: T-lymphocyte activation antigen CD86 (mouse) namespace: protein def: "A CD86 molecule that is encoded in the genome of mouse." [OMA:P42082, PRO:DNx] comment: Category=organism-gene. synonym: "activation B7-2 antigen (mouse)" EXACT [UniProtKB:P42082] synonym: "Cd86" RELATED Gene-based [UniProtKB:P42082] synonym: "CD86 (mouse)" EXACT [UniProtKB:P42082] synonym: "early T-cell costimulatory molecule 1 (mouse)" EXACT [UniProtKB:P42082] synonym: "ETC-1 (mouse)" EXACT [UniProtKB:P42082] synonym: "mCD86" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:P42082 is_a: PR:000001412 ! CD86 molecule is_a: PR:000029032 ! Mus musculus protein intersection_of: PR:000001412 ! CD86 molecule intersection_of: RO:0002160 NCBITaxon:10090 ! only in taxon Mus musculus [Term] id: PR:P43235 name: cathepsin K (human) namespace: protein def: "A cathepsin K that is encoded in the genome of human." [PRO:WCB, UniProtKB:P43235] comment: Category=organism-gene. synonym: "cathepsin O (human)" RELATED [UniProtKB:P43235] synonym: "cathepsin O2 (human)" EXACT [UniProtKB:P43235] synonym: "cathepsin X (human)" BROAD [UniProtKB:P43235] synonym: "CTSK" RELATED Gene-based [UniProtKB:P43235] synonym: "CTSO" RELATED Gene-based [UniProtKB:P43235] synonym: "CTSO2" RELATED Gene-based [UniProtKB:P43235] synonym: "hCTSK" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:P43235 is_a: PR:000001850 ! cathepsin K is_a: PR:000029067 ! Homo sapiens protein intersection_of: PR:000001850 ! cathepsin K intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:P43699 name: homeobox protein Nkx-2.1 (human) namespace: protein def: "A homeobox protein Nkx-2.1 that is encoded in the genome of human." [PRO:DNx, UniProtKB:P43699] comment: Category=organism-gene. synonym: "hNKX2-1" EXACT PRO-short-label [PRO:DNx] synonym: "homeobox protein NK-2 homolog A (human)" EXACT [UniProtKB:P43699] synonym: "NKX2-1" RELATED Gene-based [UniProtKB:P43699] synonym: "NKX2A" RELATED Gene-based [UniProtKB:P43699] synonym: "T/EBP (human)" EXACT [UniProtKB:P43699] synonym: "thyroid nuclear factor 1 (human)" EXACT [UniProtKB:P43699] synonym: "thyroid transcription factor 1 (human)" EXACT [UniProtKB:P43699] synonym: "thyroid-specific enhancer-binding protein (human)" EXACT [UniProtKB:P43699] synonym: "TITF1" RELATED Gene-based [UniProtKB:P43699] synonym: "TTF-1 (human)" BROAD [UniProtKB:P43699] synonym: "TTF1" RELATED Gene-based [UniProtKB:P43699] xref: UniProtKB:P43699 is_a: PR:000011241 ! homeobox protein Nkx-2.1 is_a: PR:000029067 ! Homo sapiens protein intersection_of: PR:000011241 ! homeobox protein Nkx-2.1 intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:P47212 name: galanin peptides (mouse) namespace: protein def: "A galanin that is encoded in the genome of mouse." [OMA:P47212, PRO:DNx] comment: Category=organism-gene. synonym: "Gal" RELATED Gene-based [UniProtKB:P47212] synonym: "Galn" RELATED Gene-based [UniProtKB:P47212] synonym: "mGAL" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:P47212 is_a: PR:000007806 ! galanin is_a: PR:000029032 ! Mus musculus protein intersection_of: PR:000007806 ! galanin intersection_of: RO:0002160 NCBITaxon:10090 ! only in taxon Mus musculus [Term] id: PR:P47774 name: C-C chemokine receptor type 7 (mouse) namespace: protein def: "A C-C chemokine receptor type 7 that is encoded in the genome of mouse." [OMA:P47774, PRO:DNx] comment: Category=organism-gene. synonym: "C-C CKR-7 (mouse)" EXACT [UniProtKB:P47774] synonym: "CC-CKR-7 (mouse)" EXACT [UniProtKB:P47774] synonym: "CCR-7 (mouse)" EXACT [UniProtKB:P47774] synonym: "Ccr7" RELATED Gene-based [UniProtKB:P47774] synonym: "CD197 (mouse)" EXACT [UniProtKB:P47774] synonym: "Cmkbr7" RELATED Gene-based [UniProtKB:P47774] synonym: "Ebi1" RELATED Gene-based [UniProtKB:P47774] synonym: "EBI1 (mouse)" EXACT [UniProtKB:P47774] synonym: "Ebi1h" RELATED Gene-based [UniProtKB:P47774] synonym: "EBV-induced G-protein coupled receptor 1 (mouse)" EXACT [UniProtKB:P47774] synonym: "epstein-Barr virus-induced G-protein coupled receptor 1 (mouse)" EXACT [UniProtKB:P47774] synonym: "mCCR7" EXACT PRO-short-label [PRO:DNx] synonym: "MIP-3 beta receptor (mouse)" EXACT [UniProtKB:P47774] xref: UniProtKB:P47774 is_a: PR:000001203 ! C-C chemokine receptor type 7 is_a: PR:000029032 ! Mus musculus protein intersection_of: PR:000001203 ! C-C chemokine receptor type 7 intersection_of: RO:0002160 NCBITaxon:10090 ! only in taxon Mus musculus [Term] id: PR:P48318 name: glutamate decarboxylase 1 (mouse) namespace: protein def: "A glutamate decarboxylase 1 that is encoded in the genome of mouse." [OMA:P48318, PRO:DNx] comment: Category=organism-gene. synonym: "67 kDa glutamic acid decarboxylase (mouse)" EXACT [UniProtKB:P48318] synonym: "GAD-67 (mouse)" EXACT [UniProtKB:P48318] synonym: "Gad1" RELATED Gene-based [UniProtKB:P48318] synonym: "Gad67" RELATED Gene-based [UniProtKB:P48318] synonym: "glutamate decarboxylase 67 kDa isoform (mouse)" EXACT [UniProtKB:P48318] synonym: "mGAD1" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:P48318 is_a: PR:000007785 ! glutamate decarboxylase 1 is_a: PR:000029032 ! Mus musculus protein intersection_of: PR:000007785 ! glutamate decarboxylase 1 intersection_of: RO:0002160 NCBITaxon:10090 ! only in taxon Mus musculus [Term] id: PR:P48431 name: transcription factor SOX-2 (human) namespace: protein def: "A transcription factor SOX-2 that is encoded in the genome of human." [PRO:DNx, UniProtKB:P48431] comment: Category=organism-gene. synonym: "hSOX2" EXACT PRO-short-label [PRO:DNx] synonym: "SOX2" RELATED Gene-based [UniProtKB:P48431] xref: Reactome:R-HSA-452271 "PR:P48431 located_in GO:0005654" xref: UniProtKB:P48431 is_a: PR:000015426 ! transcription factor SOX-2 is_a: PR:000029067 ! Homo sapiens protein intersection_of: PR:000015426 ! transcription factor SOX-2 intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:P48432 name: transcription factor SOX-2 (mouse) namespace: protein def: "A transcription factor SOX-2 that is encoded in the genome of mouse." [OMA:P48432, PRO:DNx] comment: Category=organism-gene. synonym: "mSOX2" EXACT PRO-short-label [PRO:DNx] synonym: "Sox-2" RELATED Gene-based [UniProtKB:P48432] synonym: "Sox2" RELATED Gene-based [UniProtKB:P48432] xref: UniProtKB:P48432 is_a: PR:000015426 ! transcription factor SOX-2 is_a: PR:000029032 ! Mus musculus protein intersection_of: PR:000015426 ! transcription factor SOX-2 intersection_of: RO:0002160 NCBITaxon:10090 ! only in taxon Mus musculus [Term] id: PR:P49238 name: CX3C chemokine receptor 1 (human) namespace: protein def: "A CX3C chemokine receptor 1 that is encoded in the genome of human." [PRO:WCB, UniProtKB:P49238] comment: Category=organism-gene. synonym: "beta chemokine receptor-like 1 (human)" EXACT [UniProtKB:P49238] synonym: "C-X3-C CKR-1 (human)" EXACT [UniProtKB:P49238] synonym: "CMK-BRL-1 (human)" EXACT [UniProtKB:P49238] synonym: "CMK-BRL1 (human)" EXACT [UniProtKB:P49238] synonym: "CMKBRL1" RELATED Gene-based [UniProtKB:P49238] synonym: "CX3CR1" RELATED Gene-based [UniProtKB:P49238] synonym: "fractalkine receptor (human)" EXACT [UniProtKB:P49238] synonym: "G-protein coupled receptor 13 (human)" EXACT [UniProtKB:P49238] synonym: "GPR13" RELATED Gene-based [UniProtKB:P49238] synonym: "hCX3CR1" EXACT PRO-short-label [PRO:DNx] synonym: "V28 (human)" EXACT [UniProtKB:P49238] xref: DTO:02100074 xref: Reactome:R-HSA-2980688 "PR:P49238 located_in GO:0005886" xref: Reactome:R-HSA-9837658 "PR:P49238 located_in GO:0160056" xref: UniProtKB:P49238 is_a: PR:000001206 ! CX3C chemokine receptor 1 is_a: PR:000029067 ! Homo sapiens protein intersection_of: PR:000001206 ! CX3C chemokine receptor 1 intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:P49290 name: eosinophil peroxidase (mouse) namespace: protein def: "An eosinophil peroxidase that is encoded in the genome of mouse." [OMA:P49290, PRO:DNx] comment: Category=organism-gene. synonym: "Eper" RELATED Gene-based [UniProtKB:P49290] synonym: "EPO (mouse)" EXACT [UniProtKB:P49290] synonym: "Epx" RELATED Gene-based [UniProtKB:P49290] synonym: "mEPX" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:P49290 is_a: PR:000007152 ! eosinophil peroxidase is_a: PR:000029032 ! Mus musculus protein intersection_of: PR:000007152 ! eosinophil peroxidase intersection_of: RO:0002160 NCBITaxon:10090 ! only in taxon Mus musculus [Term] id: PR:P49582 name: neuronal acetylcholine receptor subunit alpha-7 (mouse) namespace: protein def: "A neuronal acetylcholine receptor subunit alpha-7 that is encoded in the genome of mouse." [PRO:DAN] comment: Category=organism-gene. synonym: "Acra7" RELATED Gene-based [UniProtKB:P49582] synonym: "Chrna7" RELATED Gene-based [UniProtKB:P49582] synonym: "mChrna7" EXACT PRO-short-label [PRO:DNx] synonym: "nAChR7 (mouse)" EXACT [UniProtKB:P49582] synonym: "nicotinic acetylcholine receptor subunit alpha-7 (mouse)" EXACT [UniProtKB:P49582] xref: UniProtKB:P49582 is_a: PR:000005460 ! neuronal acetylcholine receptor subunit alpha-7 is_a: PR:000029032 ! Mus musculus protein intersection_of: PR:000005460 ! neuronal acetylcholine receptor subunit alpha-7 intersection_of: RO:0002160 NCBITaxon:10090 ! only in taxon Mus musculus [Term] id: PR:P49682 name: C-X-C chemokine receptor type 3 (human) namespace: protein def: "A C-X-C chemokine receptor type 3 that is encoded in the genome of human." [PRO:WCB, UniProtKB:P49682] comment: Category=organism-gene. synonym: "CD183 (human)" EXACT [UniProtKB:P49682] synonym: "CKR-L2 (human)" EXACT [UniProtKB:P49682] synonym: "CXC-R3 (human)" EXACT [UniProtKB:P49682] synonym: "CXCR-3 (human)" EXACT [UniProtKB:P49682] synonym: "CXCR3" RELATED Gene-based [UniProtKB:P49682] synonym: "G protein-coupled receptor 9 (human)" EXACT [UniProtKB:P49682] synonym: "GPR9" RELATED Gene-based [UniProtKB:P49682] synonym: "hCXCR3" EXACT PRO-short-label [PRO:DNx] synonym: "interferon-inducible protein 10 receptor (human)" EXACT [UniProtKB:P49682] synonym: "IP-10 receptor (human)" EXACT [UniProtKB:P49682] xref: DTO:02100077 xref: Reactome:R-HSA-2980699 "PR:P49682 located_in GO:0005886" xref: UniProtKB:P49682 is_a: PR:000001207 ! C-X-C chemokine receptor type 3 is_a: PR:000029067 ! Homo sapiens protein intersection_of: PR:000001207 ! C-X-C chemokine receptor type 3 intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:P49715 name: CCAAT/enhancer-binding protein alpha (human) namespace: protein def: "A CCAAT/enhancer-binding protein alpha that is encoded in the genome of human." [PRO:DNx, UniProtKB:P49715] comment: Category=organism-gene. synonym: "C/EBP alpha (human)" EXACT [UniProtKB:P49715] synonym: "CEBP" RELATED Gene-based [UniProtKB:P49715] synonym: "CEBPA" RELATED Gene-based [UniProtKB:P49715] synonym: "hCEBPA" EXACT PRO-short-label [PRO:DNx] xref: Reactome:R-HSA-381289 "PR:P49715 located_in GO:0005654" xref: UniProtKB:P49715 is_a: PR:000005307 ! CCAAT/enhancer-binding protein alpha is_a: PR:000029067 ! Homo sapiens protein intersection_of: PR:000005307 ! CCAAT/enhancer-binding protein alpha intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:P49863 name: granzyme K (human) namespace: protein def: "A granzyme K that is encoded in the genome of human." [PRO:CNA, UniProtKB:P49863] comment: Category=organism-gene. synonym: "fragmentin-3 (human)" EXACT [UniProtKB:P49863] synonym: "granzyme-3 (human)" EXACT [UniProtKB:P49863] synonym: "GZMK" RELATED Gene-based [UniProtKB:P49863] synonym: "hGZMK" EXACT PRO-short-label [PRO:DNx] synonym: "NK-Tryp-2 (human)" EXACT [UniProtKB:P49863] synonym: "NK-tryptase-2 (human)" EXACT [UniProtKB:P49863] synonym: "TRYP2" RELATED Gene-based [UniProtKB:P49863] xref: UniProtKB:P49863 is_a: PR:000003472 ! granzyme K is_a: PR:000029067 ! Homo sapiens protein intersection_of: PR:000003472 ! granzyme K intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:P49961 name: ectonucleoside triphosphate diphosphohydrolase 1 (human) namespace: protein def: "An ectonucleoside triphosphate diphosphohydrolase 1 that is encoded in the genome of human." [PRO:WCB, UniProtKB:P49961] comment: Category=organism-gene. synonym: "ATP diphosphohydrolase (human)" EXACT [UniProtKB:P49961] synonym: "ATP-DPH (human)" EXACT [UniProtKB:P49961] synonym: "ATPDase (human)" EXACT [UniProtKB:P49961] synonym: "CD39" RELATED Gene-based [UniProtKB:P49961] synonym: "ecto-apyrase (human)" EXACT [UniProtKB:P49961] synonym: "ecto-ATP diphosphohydrolase 1 (human)" EXACT [UniProtKB:P49961] synonym: "ecto-ATPase 1 (human)" EXACT [UniProtKB:P49961] synonym: "ecto-ATPDase 1 (human)" EXACT [UniProtKB:P49961] synonym: "ENTPD1" RELATED Gene-based [UniProtKB:P49961] synonym: "hENTPD1" EXACT PRO-short-label [PRO:DNx] synonym: "lymphoid cell activation antigen (human)" EXACT [UniProtKB:P49961] synonym: "NTPDase1 (human)" EXACT [UniProtKB:P49961] synonym: "nucleoside triphosphate diphosphohydrolase 1 (human)" EXACT [UniProtKB:P49961] xref: Reactome:R-HSA-913566 "PR:P49961 located_in GO:0005886" xref: UniProtKB:P49961 is_a: PR:000001854 ! ectonucleoside triphosphate diphosphohydrolase 1 is_a: PR:000029067 ! Homo sapiens protein intersection_of: PR:000001854 ! ectonucleoside triphosphate diphosphohydrolase 1 intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:P50114 name: protein S100-B (mouse) namespace: protein def: "A protein S100-B that is encoded in the genome of mouse." [OMA:P50114, PRO:DNx] comment: Category=organism-gene. synonym: "mS100B" EXACT PRO-short-label [PRO:DNx] synonym: "S-100 protein beta chain (mouse)" EXACT [UniProtKB:P50114] synonym: "S-100 protein subunit beta (mouse)" EXACT [UniProtKB:P50114] synonym: "S100 calcium-binding protein B (mouse)" EXACT [UniProtKB:P50114] synonym: "S100b" RELATED Gene-based [UniProtKB:P50114] xref: UniProtKB:P50114 is_a: PR:000014419 ! protein S100-B is_a: PR:000029032 ! Mus musculus protein intersection_of: PR:000014419 ! protein S100-B intersection_of: RO:0002160 NCBITaxon:10090 ! only in taxon Mus musculus [Term] id: PR:P50220 name: homeobox protein Nkx-2.1 (mouse) namespace: protein def: "A homeobox protein Nkx-2.1 that is encoded in the genome of mouse." [OMA:P50220, PRO:DNx] comment: Category=organism-gene. synonym: "mNKX2-1" EXACT PRO-short-label [PRO:DNx] synonym: "Nkx-2.1" RELATED Gene-based [UniProtKB:P50220] synonym: "Nkx2-1" RELATED Gene-based [UniProtKB:P50220] synonym: "T/EBP (mouse)" EXACT [UniProtKB:P50220] synonym: "thyroid nuclear factor 1 (mouse)" EXACT [UniProtKB:P50220] synonym: "thyroid transcription factor 1 (mouse)" EXACT [UniProtKB:P50220] synonym: "thyroid-specific enhancer-binding protein (mouse)" EXACT [UniProtKB:P50220] synonym: "Titf1" RELATED Gene-based [UniProtKB:P50220] synonym: "TTF-1 (mouse)" RELATED [UniProtKB:P50220] synonym: "Ttf1" RELATED Gene-based [UniProtKB:P50220] xref: UniProtKB:P50220 is_a: PR:000011241 ! homeobox protein Nkx-2.1 is_a: PR:000029032 ! Mus musculus protein intersection_of: PR:000011241 ! homeobox protein Nkx-2.1 intersection_of: RO:0002160 NCBITaxon:10090 ! only in taxon Mus musculus [Term] id: PR:P50283 name: T-cell antigen CD7 (mouse) namespace: protein def: "A CD7 molecule that is encoded in the genome of mouse." [OMA:P50283, PRO:DNx] comment: Category=organism-gene. synonym: "Cd7" RELATED Gene-based [UniProtKB:P50283] synonym: "CD7 (mouse)" EXACT [UniProtKB:P50283] synonym: "mCD7" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:P50283 is_a: PR:000001836 ! CD7 molecule is_a: PR:000029032 ! Mus musculus protein intersection_of: PR:000001836 ! CD7 molecule intersection_of: RO:0002160 NCBITaxon:10090 ! only in taxon Mus musculus [Term] id: PR:P50481 name: LIM/homeobox protein Lhx3 (mouse) namespace: protein def: "A LIM/homeobox protein Lhx3 that is encoded in the genome of mouse." [OMA:P50481, PRO:DNx] comment: Category=organism-gene. synonym: "homeobox protein LIM-3 (mouse)" EXACT [UniProtKB:P50481] synonym: "homeobox protein P-LIM (mouse)" EXACT [UniProtKB:P50481] synonym: "Lhx3" RELATED Gene-based [UniProtKB:P50481] synonym: "LIM homeobox protein 3 (mouse)" EXACT [UniProtKB:P50481] synonym: "Lim-3" RELATED Gene-based [UniProtKB:P50481] synonym: "Lim3" RELATED Gene-based [UniProtKB:P50481] synonym: "mLHX3" EXACT PRO-short-label [PRO:DNx] synonym: "Plim" RELATED Gene-based [UniProtKB:P50481] xref: UniProtKB:P50481 is_a: PR:000009793 ! LIM/homeobox protein Lhx3 is_a: PR:000029032 ! Mus musculus protein intersection_of: PR:000009793 ! LIM/homeobox protein Lhx3 intersection_of: RO:0002160 NCBITaxon:10090 ! only in taxon Mus musculus [Term] id: PR:P51449 name: nuclear receptor ROR-gamma (human) namespace: protein def: "A nuclear receptor ROR-gamma that is encoded in the genome of human." [PRO:WCB, UniProtKB:P51449] comment: Category=organism-gene. synonym: "hRORC" EXACT PRO-short-label [PRO:DNx] synonym: "NR1F3" RELATED Gene-based [UniProtKB:P51449] synonym: "nuclear receptor RZR-gamma (human)" EXACT [UniProtKB:P51449] synonym: "nuclear receptor subfamily 1 group F member 3 (human)" EXACT [UniProtKB:P51449] synonym: "RAR-related orphan receptor C (human)" EXACT [UniProtKB:P51449] synonym: "retinoid-related orphan receptor-gamma (human)" EXACT [UniProtKB:P51449] synonym: "RORC" RELATED Gene-based [UniProtKB:P51449] synonym: "RORG" RELATED Gene-based [UniProtKB:P51449] synonym: "RZRG" RELATED Gene-based [UniProtKB:P51449] xref: DTO:00117492 xref: Reactome:R-HSA-446177 "PR:P51449 located_in GO:0005654" xref: UniProtKB:P51449 is_a: PR:000001902 ! nuclear receptor ROR-gamma is_a: PR:000029067 ! Homo sapiens protein intersection_of: PR:000001902 ! nuclear receptor ROR-gamma intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:P51450 name: nuclear receptor ROR-gamma (mouse) namespace: protein def: "A nuclear receptor ROR-gamma that is encoded in the genome of mouse." [OMA:P51450, PRO:DNx] comment: Category=organism-gene. synonym: "mRORC" EXACT PRO-short-label [PRO:DNx] synonym: "Nr1f3" RELATED Gene-based [UniProtKB:P51450] synonym: "nuclear receptor RZR-gamma (mouse)" EXACT [UniProtKB:P51450] synonym: "nuclear receptor subfamily 1 group F member 3 (mouse)" EXACT [UniProtKB:P51450] synonym: "RAR-related orphan receptor C (mouse)" EXACT [UniProtKB:P51450] synonym: "retinoid-related orphan receptor-gamma (mouse)" EXACT [UniProtKB:P51450] synonym: "Rorc" RELATED Gene-based [UniProtKB:P51450] synonym: "Rorg" RELATED Gene-based [UniProtKB:P51450] synonym: "Thor" RELATED Gene-based [UniProtKB:P51450] synonym: "thymus orphan receptor (mouse)" EXACT [UniProtKB:P51450] synonym: "TOR (mouse)" EXACT [UniProtKB:P51450] xref: UniProtKB:P51450 is_a: PR:000001902 ! nuclear receptor ROR-gamma is_a: PR:000029032 ! Mus musculus protein intersection_of: PR:000001902 ! nuclear receptor ROR-gamma intersection_of: RO:0002160 NCBITaxon:10090 ! only in taxon Mus musculus [Term] id: PR:P51450-2 name: nuclear receptor ROR-gamma isoform 2 (mouse) namespace: protein def: "A nuclear receptor ROR-gamma isoform 2 that is encoded in the genome of mouse." [PRO:CNA] comment: Category=organism-sequence. synonym: "mRORC/iso:2" EXACT PRO-short-label [PRO:DNx] synonym: "nuclear receptor ROR-gamma isoform RORgT (mouse)" EXACT [UniProtKB:P51450] xref: UniProtKB:P51450-2 is_a: PR:000003455 ! nuclear receptor ROR-gamma isoform 2 is_a: PR:P51450 ! nuclear receptor ROR-gamma (mouse) intersection_of: PR:000003455 ! nuclear receptor ROR-gamma isoform 2 intersection_of: RO:0002160 NCBITaxon:10090 ! only in taxon Mus musculus [Term] id: PR:P51675 name: C-C chemokine receptor type 1 (mouse) namespace: protein def: "A C-C chemokine receptor type 1 that is encoded in the genome of mouse." [OMA:P51675, PRO:DNx] comment: Category=organism-gene. synonym: "C-C CKR-1 (mouse)" EXACT [UniProtKB:P51675] synonym: "CC-CKR-1 (mouse)" EXACT [UniProtKB:P51675] synonym: "CCR-1 (mouse)" EXACT [UniProtKB:P51675] synonym: "Ccr1" RELATED Gene-based [UniProtKB:P51675] synonym: "CCR1 (mouse)" EXACT [UniProtKB:P51675] synonym: "CD191 (mouse)" EXACT [UniProtKB:P51675] synonym: "Cmkbr1" RELATED Gene-based [UniProtKB:P51675] synonym: "macrophage inflammatory protein 1-alpha receptor (mouse)" EXACT [UniProtKB:P51675] synonym: "mCCR1" EXACT PRO-short-label [PRO:DNx] synonym: "MIP-1alpha-R (mouse)" EXACT [UniProtKB:P51675] synonym: "RANTES-R (mouse)" EXACT [UniProtKB:P51675] xref: UniProtKB:P51675 is_a: PR:000001254 ! C-C chemokine receptor type 1 is_a: PR:000029032 ! Mus musculus protein intersection_of: PR:000001254 ! C-C chemokine receptor type 1 intersection_of: RO:0002160 NCBITaxon:10090 ! only in taxon Mus musculus [Term] id: PR:P51677 name: C-C chemokine receptor type 3 (human) namespace: protein def: "A C-C chemokine receptor type 3 that is encoded in the genome of human." [PRO:WCB, UniProtKB:P51677] comment: Category=organism-gene. synonym: "C C CKR3 (human)" EXACT [UniProtKB:P51677] synonym: "C-C CKR-3 (human)" EXACT [UniProtKB:P51677] synonym: "CC-CKR-3 (human)" EXACT [UniProtKB:P51677] synonym: "CCR-3 (human)" EXACT [UniProtKB:P51677] synonym: "CCR3" RELATED Gene-based [UniProtKB:P51677] synonym: "CD193 (human)" EXACT [UniProtKB:P51677] synonym: "CKR 3 (human)" EXACT [UniProtKB:P51677] synonym: "CKR3 (human)" EXACT [UniProtKB:P51677] synonym: "CMKBR3" RELATED Gene-based [UniProtKB:P51677] synonym: "eosinophil eotaxin receptor (human)" EXACT [UniProtKB:P51677] synonym: "hCCR3" EXACT PRO-short-label [PRO:DNx] xref: DTO:02100055 xref: Reactome:R-HSA-373106 "PR:P51677 located_in GO:0005886" xref: UniProtKB:P51677 is_a: PR:000001255 ! C-C chemokine receptor type 3 is_a: PR:000029067 ! Homo sapiens protein intersection_of: PR:000001255 ! C-C chemokine receptor type 3 intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:P51678 name: probable C-C chemokine receptor type 3 (mouse) namespace: protein def: "A C-C chemokine receptor type 3 that is encoded in the genome of mouse." [OMA:P51678, PRO:DNx] comment: Category=organism-gene. synonym: "C-C CKR-3 (mouse)" EXACT [UniProtKB:P51678] synonym: "CC-CKR-3 (mouse)" EXACT [UniProtKB:P51678] synonym: "CCR-3 (mouse)" EXACT [UniProtKB:P51678] synonym: "Ccr3" RELATED Gene-based [UniProtKB:P51678] synonym: "CCR3 (mouse)" EXACT [UniProtKB:P51678] synonym: "CD193 (mouse)" EXACT [UniProtKB:P51678] synonym: "CKR3 (mouse)" EXACT [UniProtKB:P51678] synonym: "Cmkbr1l2" RELATED Gene-based [UniProtKB:P51678] synonym: "Cmkbr3" RELATED Gene-based [UniProtKB:P51678] synonym: "macrophage inflammatory protein 1-alpha receptor-like 2 (mouse)" EXACT [UniProtKB:P51678] synonym: "mCCR3" EXACT PRO-short-label [PRO:DNx] synonym: "MIP-1 alpha RL2 (mouse)" EXACT [UniProtKB:P51678] xref: UniProtKB:P51678 is_a: PR:000001255 ! C-C chemokine receptor type 3 is_a: PR:000029032 ! Mus musculus protein intersection_of: PR:000001255 ! C-C chemokine receptor type 3 intersection_of: RO:0002160 NCBITaxon:10090 ! only in taxon Mus musculus [Term] id: PR:P51679 name: C-C chemokine receptor type 4 (human) namespace: protein def: "A C-C chemokine receptor type 4 that is encoded in the genome of human." [PRO:WCB, UniProtKB:P51679] comment: Category=organism-gene. synonym: "C-C CKR-4 (human)" EXACT [UniProtKB:P51679] synonym: "CC-CKR-4 (human)" EXACT [UniProtKB:P51679] synonym: "CCR-4 (human)" EXACT [UniProtKB:P51679] synonym: "CCR4" RELATED Gene-based [UniProtKB:P51679] synonym: "CD194 (human)" EXACT [UniProtKB:P51679] synonym: "CMKBR4" RELATED Gene-based [UniProtKB:P51679] synonym: "hCCR4" EXACT PRO-short-label [PRO:DNx] synonym: "K5-5 (human)" EXACT [UniProtKB:P51679] xref: DTO:02100056 xref: Reactome:R-HSA-373090 "PR:P51679 located_in GO:0005886" xref: UniProtKB:P51679 is_a: PR:000001200 ! C-C chemokine receptor type 4 is_a: PR:000029067 ! Homo sapiens protein intersection_of: PR:000001200 ! C-C chemokine receptor type 4 intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:P51680 name: C-C chemokine receptor type 4 (mouse) namespace: protein def: "A C-C chemokine receptor type 4 that is encoded in the genome of mouse." [OMA:P51680, PRO:DNx] comment: Category=organism-gene. synonym: "C-C CKR-4 (mouse)" EXACT [UniProtKB:P51680] synonym: "CC-CKR-4 (mouse)" EXACT [UniProtKB:P51680] synonym: "CCR-4 (mouse)" EXACT [UniProtKB:P51680] synonym: "Ccr4" RELATED Gene-based [UniProtKB:P51680] synonym: "CCR4 (mouse)" EXACT [UniProtKB:P51680] synonym: "CD194 (mouse)" EXACT [UniProtKB:P51680] synonym: "Cmkbr4" RELATED Gene-based [UniProtKB:P51680] synonym: "mCCR4" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:P51680 is_a: PR:000001200 ! C-C chemokine receptor type 4 is_a: PR:000029032 ! Mus musculus protein intersection_of: PR:000001200 ! C-C chemokine receptor type 4 intersection_of: RO:0002160 NCBITaxon:10090 ! only in taxon Mus musculus [Term] id: PR:P51681 name: C-C chemokine receptor type 5 (human) namespace: protein def: "A C-C chemokine receptor type 5 that is encoded in the genome of human." [PRO:WCB, UniProtKB:P51681] comment: Category=organism-gene. synonym: "C-C CKR-5 (human)" EXACT [UniProtKB:P51681] synonym: "CC-CKR-5 (human)" EXACT [UniProtKB:P51681] synonym: "CCR-5 (human)" EXACT [UniProtKB:P51681] synonym: "CCR5" RELATED Gene-based [UniProtKB:P51681] synonym: "CD195 (human)" EXACT [UniProtKB:P51681] synonym: "CHEMR13 (human)" EXACT [UniProtKB:P51681] synonym: "CMKBR5" RELATED Gene-based [UniProtKB:P51681] synonym: "hCCR5" EXACT PRO-short-label [PRO:DNx] synonym: "HIV-1 fusion coreceptor (human)" EXACT [UniProtKB:P51681] xref: DTO:02100057 xref: Reactome:R-HSA-171279 "PR:P51681 located_in GO:0005886" xref: UniProtKB:P51681 is_a: PR:000001201 ! C-C chemokine receptor type 5 is_a: PR:000029067 ! Homo sapiens protein intersection_of: PR:000001201 ! C-C chemokine receptor type 5 intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:P51682 name: C-C chemokine receptor type 5 (mouse) namespace: protein def: "A C-C chemokine receptor type 5 that is encoded in the genome of mouse." [OMA:P51682, PRO:DNx] comment: Category=organism-gene. synonym: "C-C CKR-5 (mouse)" EXACT [UniProtKB:P51682] synonym: "CC-CKR-5 (mouse)" EXACT [UniProtKB:P51682] synonym: "CCR-5 (mouse)" EXACT [UniProtKB:P51682] synonym: "Ccr5" RELATED Gene-based [UniProtKB:P51682] synonym: "CD195 (mouse)" EXACT [UniProtKB:P51682] synonym: "Cmkbr5" RELATED Gene-based [UniProtKB:P51682] synonym: "mCCR5" EXACT PRO-short-label [PRO:DNx] synonym: "MIP-1 alpha receptor (mouse)" EXACT [UniProtKB:P51682] xref: UniProtKB:P51682 is_a: PR:000001201 ! C-C chemokine receptor type 5 is_a: PR:000029032 ! Mus musculus protein intersection_of: PR:000001201 ! C-C chemokine receptor type 5 intersection_of: RO:0002160 NCBITaxon:10090 ! only in taxon Mus musculus [Term] id: PR:P51683 name: C-C chemokine receptor type 2 (mouse) namespace: protein def: "A C-C chemokine receptor type 2 that is encoded in the genome of mouse." [OMA:P51683, PRO:DNx] comment: Category=organism-gene. synonym: "C-C CKR-2 (mouse)" EXACT [UniProtKB:P51683] synonym: "CC-CKR-2 (mouse)" EXACT [UniProtKB:P51683] synonym: "CCR-2 (mouse)" EXACT [UniProtKB:P51683] synonym: "Ccr2" RELATED Gene-based [UniProtKB:P51683] synonym: "CCR2 (mouse)" EXACT [UniProtKB:P51683] synonym: "CD192 (mouse)" EXACT [UniProtKB:P51683] synonym: "Cmkbr2" RELATED Gene-based [UniProtKB:P51683] synonym: "JE/FIC receptor (mouse)" EXACT [UniProtKB:P51683] synonym: "mCCR2" EXACT PRO-short-label [PRO:DNx] synonym: "MCP-1 receptor (mouse)" EXACT [UniProtKB:P51683] xref: UniProtKB:P51683 is_a: PR:000001199 ! C-C chemokine receptor type 2 is_a: PR:000029032 ! Mus musculus protein intersection_of: PR:000001199 ! C-C chemokine receptor type 2 intersection_of: RO:0002160 NCBITaxon:10090 ! only in taxon Mus musculus [Term] id: PR:P51684 name: C-C chemokine receptor type 6 (human) namespace: protein def: "A C-C chemokine receptor type 6 that is encoded in the genome of human." [PRO:WCB, UniProtKB:P51684] comment: Category=organism-gene. synonym: "C-C CKR-6 (human)" EXACT [UniProtKB:P51684] synonym: "CC-CKR-6 (human)" EXACT [UniProtKB:P51684] synonym: "CCR-6 (human)" EXACT [UniProtKB:P51684] synonym: "CCR6" RELATED Gene-based [UniProtKB:P51684] synonym: "CD196 (human)" EXACT [UniProtKB:P51684] synonym: "chemokine receptor-like 3 (human)" EXACT [UniProtKB:P51684] synonym: "CKR-L3 (human)" EXACT [UniProtKB:P51684] synonym: "CKRL3" RELATED Gene-based [UniProtKB:P51684] synonym: "CMKBR6" RELATED Gene-based [UniProtKB:P51684] synonym: "DRY6 (human)" EXACT [UniProtKB:P51684] synonym: "G-protein coupled receptor 29 (human)" EXACT [UniProtKB:P51684] synonym: "GPR-CY4 (human)" EXACT [UniProtKB:P51684] synonym: "GPR29" RELATED Gene-based [UniProtKB:P51684] synonym: "GPRCY4 (human)" EXACT [UniProtKB:P51684] synonym: "hCCR6" EXACT PRO-short-label [PRO:DNx] synonym: "LARC receptor (human)" EXACT [UniProtKB:P51684] synonym: "STRL22" RELATED Gene-based [UniProtKB:P51684] xref: DTO:02100058 xref: Reactome:R-HSA-373089 "PR:P51684 located_in GO:0005886" xref: UniProtKB:P51684 is_a: PR:000001202 ! C-C chemokine receptor type 6 is_a: PR:000029067 ! Homo sapiens protein intersection_of: PR:000001202 ! C-C chemokine receptor type 6 intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:P51884 name: lumican (human) namespace: protein def: "A lumican that is encoded in the genome of human." [PRO:DNx, UniProtKB:P51884] comment: Category=organism-gene. synonym: "hLUM" EXACT PRO-short-label [PRO:DNx] synonym: "keratan sulfate proteoglycan lumican (human)" EXACT [UniProtKB:P51884] synonym: "KSPG lumican (human)" EXACT [UniProtKB:P51884] synonym: "LDC" RELATED Gene-based [UniProtKB:P51884] synonym: "LUM" RELATED Gene-based [UniProtKB:P51884] synonym: "SLRR2D" RELATED Gene-based [UniProtKB:P51884] xref: UniProtKB:P51884 is_a: PR:000009981 ! lumican is_a: PR:000029067 ! Homo sapiens protein intersection_of: PR:000009981 ! lumican intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:P51885 name: lumican (mouse) namespace: protein def: "A lumican that is encoded in the genome of mouse." [OMA:P51885, PRO:DNx] comment: Category=organism-gene. synonym: "keratan sulfate proteoglycan lumican (mouse)" EXACT [UniProtKB:P51885] synonym: "KSPG lumican (mouse)" EXACT [UniProtKB:P51885] synonym: "Lcn" RELATED Gene-based [UniProtKB:P51885] synonym: "Ldc" RELATED Gene-based [UniProtKB:P51885] synonym: "Lum" RELATED Gene-based [UniProtKB:P51885] synonym: "mLUM" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:P51885 is_a: PR:000009981 ! lumican is_a: PR:000029032 ! Mus musculus protein intersection_of: PR:000009981 ! lumican intersection_of: RO:0002160 NCBITaxon:10090 ! only in taxon Mus musculus [Term] id: PR:P53566 name: CCAAT/enhancer-binding protein alpha (mouse) namespace: protein def: "A CCAAT/enhancer-binding protein alpha that is encoded in the genome of mouse." [OMA:P53566, PRO:DNx] comment: Category=organism-gene. synonym: "C/EBP alpha (mouse)" EXACT [UniProtKB:P53566] synonym: "Cebp" RELATED Gene-based [UniProtKB:P53566] synonym: "Cebpa" RELATED Gene-based [UniProtKB:P53566] synonym: "mCEBPA" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:P53566 is_a: PR:000005307 ! CCAAT/enhancer-binding protein alpha is_a: PR:000029032 ! Mus musculus protein intersection_of: PR:000005307 ! CCAAT/enhancer-binding protein alpha intersection_of: RO:0002160 NCBITaxon:10090 ! only in taxon Mus musculus [Term] id: PR:P55075 name: fibroblast growth factor 8 (human) namespace: protein def: "A fibroblast growth factor 8 that is encoded in the genome of human." [PRO:DNx, UniProtKB:P55075] comment: Category=organism-gene. synonym: "AIGF" RELATED Gene-based [UniProtKB:P55075] synonym: "androgen-induced growth factor (human)" EXACT [UniProtKB:P55075] synonym: "FGF-8 (human)" EXACT [UniProtKB:P55075] synonym: "FGF8" RELATED Gene-based [UniProtKB:P55075] synonym: "HBGF-8 (human)" BROAD [UniProtKB:P55075] synonym: "heparin-binding growth factor 8 (human)" BROAD [UniProtKB:P55075] synonym: "hFGF8" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:P55075 is_a: PR:000007499 ! fibroblast growth factor 8 is_a: PR:000029067 ! Homo sapiens protein intersection_of: PR:000007499 ! fibroblast growth factor 8 intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:P55097 name: cathepsin K (mouse) namespace: protein def: "A cathepsin K that is encoded in the genome of mouse." [OMA:P55097, PRO:DNx] comment: Category=organism-gene. synonym: "Ctsk" RELATED Gene-based [UniProtKB:P55097] synonym: "mCTSK" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:P55097 is_a: PR:000001850 ! cathepsin K is_a: PR:000029032 ! Mus musculus protein intersection_of: PR:000001850 ! cathepsin K intersection_of: RO:0002160 NCBITaxon:10090 ! only in taxon Mus musculus [Term] id: PR:P55099 name: tachykinin-3 (mouse) namespace: protein def: "A tachykinin-3 that is encoded in the genome of mouse." [OMA:P55099, PRO:DNx] comment: Category=organism-gene. synonym: "mTAC3" EXACT PRO-short-label [PRO:DNx] synonym: "neurokinin B-like protein Zneurok1 (mouse)" EXACT [UniProtKB:P55099] synonym: "Nknb" RELATED Gene-based [UniProtKB:P55099] synonym: "PPT-B (mouse)" EXACT [UniProtKB:P55099] synonym: "preprotachykinin-B (mouse)" EXACT [UniProtKB:P55099] synonym: "Tac2" RELATED Gene-based [UniProtKB:P55099] synonym: "Tac3" RELATED Gene-based [UniProtKB:P55099] xref: UniProtKB:P55099 is_a: PR:000016004 ! tachykinin-3 is_a: PR:000029032 ! Mus musculus protein intersection_of: PR:000016004 ! tachykinin-3 intersection_of: RO:0002160 NCBITaxon:10090 ! only in taxon Mus musculus [Term] id: PR:P55284 name: cadherin-5 (mouse) namespace: protein def: "A cadherin-5 that is encoded in the genome of mouse." [OMA:P55284, PRO:DNx] comment: Category=organism-gene. synonym: "CD144 (mouse)" EXACT [UniProtKB:P55284] synonym: "Cdh5" RELATED Gene-based [UniProtKB:P55284] synonym: "mCDH5" EXACT PRO-short-label [PRO:DNx] synonym: "vascular endothelial cadherin (mouse)" EXACT [UniProtKB:P55284] synonym: "VE-cadherin (mouse)" EXACT [UniProtKB:P55284] xref: UniProtKB:P55284 is_a: PR:000001444 ! cadherin-5 is_a: PR:000029032 ! Mus musculus protein intersection_of: PR:000001444 ! cadherin-5 intersection_of: RO:0002160 NCBITaxon:10090 ! only in taxon Mus musculus [Term] id: PR:P55772 name: ectonucleoside triphosphate diphosphohydrolase 1 (mouse) namespace: protein def: "An ectonucleoside triphosphate diphosphohydrolase 1 that is encoded in the genome of mouse." [OMA:P55772, PRO:DNx] comment: Category=organism-gene. synonym: "ATP diphosphohydrolase (mouse)" EXACT [UniProtKB:P55772] synonym: "ATP-DPH (mouse)" EXACT [UniProtKB:P55772] synonym: "ATPDase (mouse)" EXACT [UniProtKB:P55772] synonym: "Cd39" RELATED Gene-based [UniProtKB:P55772] synonym: "CD39 (mouse)" EXACT [UniProtKB:P55772] synonym: "ecto-apyrase (mouse)" EXACT [UniProtKB:P55772] synonym: "ecto-ATP diphosphohydrolase 1 (mouse)" EXACT [UniProtKB:P55772] synonym: "ecto-ATPase 1 (mouse)" EXACT [UniProtKB:P55772] synonym: "ecto-ATPDase 1 (mouse)" EXACT [UniProtKB:P55772] synonym: "Entpd1" RELATED Gene-based [UniProtKB:P55772] synonym: "lymphoid cell activation antigen (mouse)" EXACT [UniProtKB:P55772] synonym: "mENTPD1" EXACT PRO-short-label [PRO:DNx] synonym: "NTPDase 1 (mouse)" EXACT [UniProtKB:P55772] synonym: "NTPDase1 (mouse)" EXACT [UniProtKB:P55772] synonym: "nucleoside triphosphate diphosphohydrolase 1 (mouse)" EXACT [UniProtKB:P55772] xref: UniProtKB:P55772 is_a: PR:000001854 ! ectonucleoside triphosphate diphosphohydrolase 1 is_a: PR:000029032 ! Mus musculus protein intersection_of: PR:000001854 ! ectonucleoside triphosphate diphosphohydrolase 1 intersection_of: RO:0002160 NCBITaxon:10090 ! only in taxon Mus musculus [Term] id: PR:P55895 name: V(D)J recombination-activating protein 2 (human) namespace: protein def: "A V(D)J recombination-activating protein 2 that is encoded in the genome of human." [PRO:CNA, UniProtKB:P55895] comment: Category=organism-gene. synonym: "hRAG2" EXACT PRO-short-label [PRO:DNx] synonym: "RAG-2 (human)" EXACT [UniProtKB:P55895] synonym: "RAG2" RELATED Gene-based [UniProtKB:P55895] xref: Reactome:R-HSA-5692675 "PR:P55895 located_in GO:0005654" xref: UniProtKB:P55895 is_a: PR:000003460 ! V(D)J recombination-activating protein 2 is_a: PR:000029067 ! Homo sapiens protein intersection_of: PR:000003460 ! V(D)J recombination-activating protein 2 intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:P56199 name: integrin alpha-1 (human) namespace: protein def: "An integrin alpha-1 that is encoded in the genome of human." [PRO:CNA, UniProtKB:P56199] comment: Category=organism-gene. synonym: "CD49 antigen-like family member A (human)" EXACT [UniProtKB:P56199] synonym: "CD49a (human)" EXACT [UniProtKB:P56199] synonym: "hITGA1" EXACT PRO-short-label [PRO:DNx] synonym: "ITGA1" RELATED Gene-based [UniProtKB:P56199] synonym: "laminin and collagen receptor (human)" EXACT [UniProtKB:P56199] synonym: "VLA-1 (human)" EXACT [UniProtKB:P56199] xref: UniProtKB:P56199 is_a: PR:000001007 ! integrin alpha-1 is_a: PR:000029067 ! Homo sapiens protein intersection_of: PR:000001007 ! integrin alpha-1 intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:P56373 name: P2X purinoceptor 3 (human) namespace: protein def: "A P2X purinoceptor 3 that is encoded in the genome of human." [PRO:DNx, UniProtKB:P56373] comment: Category=organism-gene. synonym: "ATP receptor (human)" BROAD [UniProtKB:P56373] synonym: "hP2RX3" EXACT PRO-short-label [PRO:DNx] synonym: "P2RX3" RELATED Gene-based [UniProtKB:P56373] synonym: "P2X3 (human)" EXACT [UniProtKB:P56373] synonym: "purinergic receptor (human)" BROAD [UniProtKB:P56373] xref: DTO:01100266 xref: Reactome:R-HSA-8861879 "PR:P56373 located_in GO:0005886" xref: UniProtKB:P56373 is_a: PR:000012190 ! P2X purinoceptor 3 is_a: PR:000029067 ! Homo sapiens protein intersection_of: PR:000012190 ! P2X purinoceptor 3 intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:P56473 name: agouti-related protein (mouse) namespace: protein def: "An agouti-related protein that is encoded in the genome of mouse." [OMA:P56473, PRO:DNx] comment: Category=organism-gene. synonym: "Agrp" RELATED Gene-based [UniProtKB:P56473] synonym: "Agrt" RELATED Gene-based [UniProtKB:P56473] synonym: "Art" RELATED Gene-based [UniProtKB:P56473] synonym: "mAGRP" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:P56473 is_a: PR:000003846 ! agouti-related protein is_a: PR:000029032 ! Mus musculus protein intersection_of: PR:000003846 ! agouti-related protein intersection_of: RO:0002160 NCBITaxon:10090 ! only in taxon Mus musculus [Term] id: PR:P56528 name: ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 (mouse) namespace: protein def: "An ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 that is encoded in the genome of mouse." [OMA:P56528, PRO:DNx] comment: Category=organism-gene. synonym: "2'-phospho-ADP-ribosyl cyclase (mouse)" EXACT [UniProtKB:P56528] synonym: "2'-phospho-ADP-ribosyl cyclase/2'-phospho-cyclic-ADP-ribose transferase (mouse)" EXACT [UniProtKB:P56528] synonym: "2'-phospho-cyclic-ADP-ribose transferase (mouse)" EXACT [UniProtKB:P56528] synonym: "ADP-ribosyl cyclase 1 (mouse)" EXACT [UniProtKB:P56528] synonym: "ADPRC 1 (mouse)" EXACT [UniProtKB:P56528] synonym: "cADPR hydrolase 1 (mouse)" EXACT [UniProtKB:P56528] synonym: "Cd38" RELATED Gene-based [UniProtKB:P56528] synonym: "CD38 (mouse)" EXACT [UniProtKB:P56528] synonym: "cyclic ADP-ribose hydrolase 1 (mouse)" EXACT [UniProtKB:P56528] synonym: "I-19 (mouse)" EXACT [UniProtKB:P56528] synonym: "mCD38" EXACT PRO-short-label [PRO:DNx] synonym: "NIM-R5 antigen (mouse)" EXACT [UniProtKB:P56528] xref: UniProtKB:P56528 is_a: PR:000001408 ! ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 is_a: PR:000029032 ! Mus musculus protein intersection_of: PR:000001408 ! ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 intersection_of: RO:0002160 NCBITaxon:10090 ! only in taxon Mus musculus [Term] id: PR:P57774 name: pro-neuropeptide Y (mouse) namespace: protein def: "A neuropeptide Y that is encoded in the genome of mouse." [OMA:P57774, PRO:DNx] comment: Category=organism-gene. synonym: "mNPY" EXACT PRO-short-label [PRO:DNx] synonym: "Npy" RELATED Gene-based [UniProtKB:P57774] xref: UniProtKB:P57774 is_a: PR:000011387 ! neuropeptide Y is_a: PR:000029032 ! Mus musculus protein intersection_of: PR:000011387 ! neuropeptide Y intersection_of: RO:0002160 NCBITaxon:10090 ! only in taxon Mus musculus [Term] id: PR:P58462 name: forkhead box protein P1 (mouse) namespace: protein def: "A forkhead box protein P1 that is encoded in the genome of mouse." [OMA:P58462, PRO:DNx] comment: Category=organism-gene. synonym: "forkhead-related transcription factor 1 (mouse)" RELATED [UniProtKB:P58462] synonym: "Foxp1" RELATED Gene-based [UniProtKB:P58462] synonym: "mFOXP1" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:P58462 is_a: PR:000007643 ! forkhead box protein P1 is_a: PR:000029032 ! Mus musculus protein intersection_of: PR:000007643 ! forkhead box protein P1 intersection_of: RO:0002160 NCBITaxon:10090 ! only in taxon Mus musculus [Term] id: PR:P59901 name: leukocyte immunoglobulin-like receptor subfamily A member 4 (human) namespace: protein def: "A leukocyte immunoglobulin-like receptor subfamily A member 4 that is encoded in the genome of human." [PRO:WCB, UniProtKB:P59901] comment: Category=organism-gene. synonym: "CD85 antigen-like family member G (human)" EXACT [UniProtKB:P59901] synonym: "CD85g (human)" EXACT [UniProtKB:P59901] synonym: "hLILRA4" EXACT PRO-short-label [PRO:DNx] synonym: "ILT-7 (human)" EXACT [UniProtKB:P59901] synonym: "ILT7" RELATED Gene-based [UniProtKB:P59901] synonym: "immunoglobulin-like transcript 7 (human)" EXACT [UniProtKB:P59901] synonym: "LILRA4" RELATED Gene-based [UniProtKB:P59901] xref: UniProtKB:P59901 is_a: PR:000001398 ! leukocyte immunoglobulin-like receptor subfamily A member 4 is_a: PR:000029067 ! Homo sapiens protein intersection_of: PR:000001398 ! leukocyte immunoglobulin-like receptor subfamily A member 4 intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:P60041 name: somatostatin (mouse) namespace: protein def: "A somatostatin that is encoded in the genome of mouse." [OMA:P60041, PRO:DNx] comment: Category=organism-gene. synonym: "mSST" EXACT PRO-short-label [PRO:DNx] synonym: "Smst" RELATED Gene-based [UniProtKB:P60041] synonym: "Sst" RELATED Gene-based [UniProtKB:P60041] xref: UniProtKB:P60041 is_a: PR:000015665 ! somatostatin is_a: PR:000029032 ! Mus musculus protein intersection_of: PR:000015665 ! somatostatin intersection_of: RO:0002160 NCBITaxon:10090 ! only in taxon Mus musculus [Term] id: PR:P61073 name: C-X-C chemokine receptor type 4 (human) namespace: protein def: "A C-X-C chemokine receptor type 4 that is encoded in the genome of human." [PRO:WCB, UniProtKB:P61073] comment: Category=organism-gene. synonym: "CD184 (human)" EXACT [UniProtKB:P61073] synonym: "CXC-R4 (human)" EXACT [UniProtKB:P61073] synonym: "CXCR-4 (human)" EXACT [UniProtKB:P61073] synonym: "CXCR4" RELATED Gene-based [UniProtKB:P61073] synonym: "FB22 (human)" EXACT [UniProtKB:P61073] synonym: "fusin (human)" EXACT [UniProtKB:P61073] synonym: "hCXCR4" EXACT PRO-short-label [PRO:DNx] synonym: "HM89 (human)" EXACT [UniProtKB:P61073] synonym: "LAP-3 (human)" BROAD [UniProtKB:P61073] synonym: "LCR1 (human)" EXACT [UniProtKB:P61073] synonym: "LESTR (human)" EXACT [UniProtKB:P61073] synonym: "leukocyte-derived seven transmembrane domain receptor (human)" EXACT [UniProtKB:P61073] synonym: "lipopolysaccharide-associated protein 3 (human)" EXACT [UniProtKB:P61073] synonym: "LPS-associated protein 3 (human)" EXACT [UniProtKB:P61073] synonym: "NPYRL (human)" EXACT [UniProtKB:P61073] synonym: "SDF-1 receptor (human)" EXACT [UniProtKB:P61073] synonym: "stromal cell-derived factor 1 receptor (human)" EXACT [UniProtKB:P61073] xref: DTO:02100078 xref: Reactome:R-HSA-2980772 "PR:P61073 located_in GO:0005886" xref: UniProtKB:P61073 is_a: PR:000001208 ! C-X-C chemokine receptor type 4 is_a: PR:000029067 ! Homo sapiens protein intersection_of: PR:000001208 ! C-X-C chemokine receptor type 4 intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:P61148 name: fibroblast growth factor 1 (mouse) namespace: protein def: "A fibroblast growth factor 1 that is encoded in the genome of mouse." [OMA:P61148, PRO:DNx] comment: Category=organism-gene. synonym: "acidic fibroblast growth factor (mouse)" EXACT [UniProtKB:P61148] synonym: "aFGF (mouse)" EXACT [UniProtKB:P61148] synonym: "Fgf-1" RELATED Gene-based [UniProtKB:P61148] synonym: "FGF-1 (mouse)" EXACT [UniProtKB:P61148] synonym: "Fgf1" RELATED Gene-based [UniProtKB:P61148] synonym: "Fgfa" RELATED Gene-based [UniProtKB:P61148] synonym: "HBGF-1 (mouse)" EXACT [UniProtKB:P61148] synonym: "heparin-binding growth factor 1 (mouse)" EXACT [UniProtKB:P61148] synonym: "mFGF1" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:P61148 is_a: PR:000007479 ! fibroblast growth factor 1 is_a: PR:000029032 ! Mus musculus protein intersection_of: PR:000007479 ! fibroblast growth factor 1 intersection_of: RO:0002160 NCBITaxon:10090 ! only in taxon Mus musculus [Term] id: PR:P61168 name: D(2) dopamine receptor (mouse) namespace: protein def: "A D(2) dopamine receptor that is encoded in the genome of mouse." [OMA:P61168, PRO:DNx] comment: Category=organism-gene. synonym: "dopamine D2 receptor (mouse)" EXACT [UniProtKB:P61168] synonym: "Drd2" RELATED Gene-based [UniProtKB:P61168] synonym: "mDRD2" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:P61168 is_a: PR:000001177 ! D(2) dopamine receptor is_a: PR:000029032 ! Mus musculus protein intersection_of: PR:000001177 ! D(2) dopamine receptor intersection_of: RO:0002160 NCBITaxon:10090 ! only in taxon Mus musculus [Term] id: PR:P61278 name: somatostatin (human) namespace: protein def: "A somatostatin that is encoded in the genome of human." [PRO:DNx, UniProtKB:P61278] comment: Category=organism-gene. synonym: "growth hormone release-inhibiting factor (human)" EXACT [UniProtKB:P61278] synonym: "hSST" EXACT PRO-short-label [PRO:DNx] synonym: "SST" RELATED Gene-based [UniProtKB:P61278] xref: UniProtKB:P61278 is_a: PR:000015665 ! somatostatin is_a: PR:000029067 ! Homo sapiens protein intersection_of: PR:000015665 ! somatostatin intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:P62736 name: actin, aortic smooth muscle (human) namespace: protein def: "An actin, aortic smooth muscle that is encoded in the genome of human." [PRO:DNx, UniProtKB:P62736] comment: Category=organism-gene. synonym: "ACTA2" RELATED Gene-based [UniProtKB:P62736] synonym: "ACTSA" RELATED Gene-based [UniProtKB:P62736] synonym: "ACTVS" RELATED Gene-based [UniProtKB:P62736] synonym: "alpha-actin-2 (human)" EXACT [UniProtKB:P62736] synonym: "cell growth-inhibiting gene 46 protein (human)" EXACT [UniProtKB:P62736] synonym: "GIG46" RELATED Gene-based [UniProtKB:P62736] synonym: "hACTA2" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:P62736 is_a: PR:000003675 ! actin, aortic smooth muscle is_a: PR:000029067 ! Homo sapiens protein intersection_of: PR:000003675 ! actin, aortic smooth muscle intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:P62737 name: actin, aortic smooth muscle (mouse) namespace: protein def: "An actin, aortic smooth muscle that is encoded in the genome of mouse." [OMA:P62737, PRO:DNx] comment: Category=organism-gene. synonym: "Acta2" RELATED Gene-based [UniProtKB:P62737] synonym: "Actsa" RELATED Gene-based [UniProtKB:P62737] synonym: "Actvs" RELATED Gene-based [UniProtKB:P62737] synonym: "alpha-actin-2 (mouse)" EXACT [UniProtKB:P62737] synonym: "mACTA2" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:P62737 is_a: PR:000003675 ! actin, aortic smooth muscle is_a: PR:000029032 ! Mus musculus protein intersection_of: PR:000003675 ! actin, aortic smooth muscle intersection_of: RO:0002160 NCBITaxon:10090 ! only in taxon Mus musculus [Term] id: PR:P63015 name: paired box protein Pax-6 (mouse) namespace: protein def: "A paired box protein Pax-6 that is encoded in the genome of mouse." [OMA:P63015, PRO:DNx] comment: Category=organism-gene. synonym: "mPAX6" EXACT PRO-short-label [PRO:DNx] synonym: "oculorhombin (mouse)" EXACT [UniProtKB:P63015] synonym: "Pax-6" RELATED Gene-based [UniProtKB:P63015] synonym: "Pax6" RELATED Gene-based [UniProtKB:P63015] synonym: "Sey" RELATED Gene-based [UniProtKB:P63015] xref: UniProtKB:P63015 is_a: PR:000012318 ! paired box protein Pax-6 is_a: PR:000029032 ! Mus musculus protein intersection_of: PR:000012318 ! paired box protein Pax-6 intersection_of: RO:0002160 NCBITaxon:10090 ! only in taxon Mus musculus [Term] id: PR:P70658 name: C-X-C chemokine receptor type 4 (mouse) namespace: protein def: "A C-X-C chemokine receptor type 4 that is encoded in the genome of mouse." [OMA:P70658, PRO:DNx] comment: Category=organism-gene. synonym: "CD184 (mouse)" EXACT [UniProtKB:P70658] synonym: "Cmkar4" RELATED Gene-based [UniProtKB:P70658] synonym: "CXC-R4 (mouse)" EXACT [UniProtKB:P70658] synonym: "CXCR-4 (mouse)" EXACT [UniProtKB:P70658] synonym: "Cxcr4" RELATED Gene-based [UniProtKB:P70658] synonym: "fusin (mouse)" EXACT [UniProtKB:P70658] synonym: "Lestr" RELATED Gene-based [UniProtKB:P70658] synonym: "LESTR (mouse)" EXACT [UniProtKB:P70658] synonym: "leukocyte-derived seven transmembrane domain receptor (mouse)" EXACT [UniProtKB:P70658] synonym: "mCXCR4" EXACT PRO-short-label [PRO:DNx] synonym: "PB-CKR (mouse)" EXACT [UniProtKB:P70658] synonym: "pre-B-cell-derived chemokine receptor (mouse)" EXACT [UniProtKB:P70658] synonym: "SDF-1 receptor (mouse)" EXACT [UniProtKB:P70658] synonym: "Sdf1r" RELATED Gene-based [UniProtKB:P70658] synonym: "stromal cell-derived factor 1 receptor (mouse)" EXACT [UniProtKB:P70658] xref: UniProtKB:P70658 is_a: PR:000001208 ! C-X-C chemokine receptor type 4 is_a: PR:000029032 ! Mus musculus protein intersection_of: PR:000001208 ! C-X-C chemokine receptor type 4 intersection_of: RO:0002160 NCBITaxon:10090 ! only in taxon Mus musculus [Term] id: PR:P70663 name: SPARC-like protein 1 (mouse) namespace: protein def: "A SPARC-like protein 1 that is encoded in the genome of mouse." [OMA:P70663, PRO:DNx] comment: Category=organism-gene. synonym: "Ecm2" RELATED Gene-based [UniProtKB:P70663] synonym: "extracellular matrix protein 2 (mouse)" RELATED [PRO:DNx, UniProtKB:P70663] synonym: "matrix glycoprotein Sc1 (mouse)" EXACT [UniProtKB:P70663] synonym: "mSPARCL1" EXACT PRO-short-label [PRO:DNx] synonym: "Sc1" RELATED Gene-based [UniProtKB:P70663] synonym: "Sparcl1" RELATED Gene-based [UniProtKB:P70663] xref: UniProtKB:P70663 is_a: PR:000015476 ! SPARC-like protein 1 is_a: PR:000029032 ! Mus musculus protein intersection_of: PR:000015476 ! SPARC-like protein 1 intersection_of: RO:0002160 NCBITaxon:10090 ! only in taxon Mus musculus [Term] id: PR:P78324 name: tyrosine-protein phosphatase non-receptor type substrate 1 (human) namespace: protein def: "A tyrosine-protein phosphatase non-receptor type substrate 1 that is encoded in the genome of human." [PRO:WCB, UniProtKB:P78324] comment: Category=organism-gene. synonym: "BIT" RELATED Gene-based [UniProtKB:P78324] synonym: "brain Ig-like molecule with tyrosine-based activation motifs (human)" EXACT [UniProtKB:P78324] synonym: "CD172 antigen-like family member A (human)" EXACT [UniProtKB:P78324] synonym: "CD172a (human)" EXACT [UniProtKB:P78324] synonym: "hSIRPA" EXACT PRO-short-label [PRO:DNx] synonym: "inhibitory receptor SHPS-1 (human)" EXACT [UniProtKB:P78324] synonym: "macrophage fusion receptor (human)" EXACT [UniProtKB:P78324] synonym: "MFR" RELATED Gene-based [UniProtKB:P78324] synonym: "MyD-1 antigen (human)" EXACT [UniProtKB:P78324] synonym: "MYD1" RELATED Gene-based [UniProtKB:P78324] synonym: "p84 (human)" BROAD [UniProtKB:P78324] synonym: "PTPNS1" RELATED Gene-based [UniProtKB:P78324] synonym: "SHP substrate 1 (human)" EXACT [UniProtKB:P78324] synonym: "SHPS-1 (human)" EXACT [UniProtKB:P78324] synonym: "SHPS1" RELATED Gene-based [UniProtKB:P78324] synonym: "signal-regulatory protein alpha-1 (human)" EXACT [UniProtKB:P78324] synonym: "signal-regulatory protein alpha-2 (human)" EXACT [UniProtKB:P78324] synonym: "signal-regulatory protein alpha-3 (human)" EXACT [UniProtKB:P78324] synonym: "SIRP" RELATED Gene-based [UniProtKB:P78324] synonym: "Sirp-alpha-1 (human)" EXACT [UniProtKB:P78324] synonym: "Sirp-alpha-2 (human)" EXACT [UniProtKB:P78324] synonym: "Sirp-alpha-3 (human)" EXACT [UniProtKB:P78324] synonym: "SIRPA" RELATED Gene-based [UniProtKB:P78324] xref: UniProtKB:P78324 is_a: PR:000001968 ! tyrosine-protein phosphatase non-receptor type substrate 1 is_a: PR:000029067 ! Homo sapiens protein intersection_of: PR:000001968 ! tyrosine-protein phosphatase non-receptor type substrate 1 intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:P78412 name: iroquois-class homeodomain protein IRX-6 (human) namespace: protein def: "An iroquois-class homeodomain protein IRX-6 that is encoded in the genome of human." [PRO:DNx, UniProtKB:P78412] comment: Category=organism-gene. synonym: "hIRX6" EXACT PRO-short-label [PRO:DNx] synonym: "homeodomain protein IRXB3 (human)" EXACT [UniProtKB:P78412] synonym: "iroquois homeobox protein 6 (human)" EXACT [UniProtKB:P78412] synonym: "IRX6" RELATED Gene-based [UniProtKB:P78412] synonym: "IRX7" RELATED Gene-based [UniProtKB:P78412] synonym: "IRXB3" RELATED Gene-based [UniProtKB:P78412] xref: UniProtKB:P78412 is_a: PR:000029067 ! Homo sapiens protein is_a: PR:000029562 ! iroquois-class homeodomain protein IRX-6 intersection_of: PR:000029562 ! iroquois-class homeodomain protein IRX-6 intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:P78424 name: POU domain, class 6, transcription factor 2 (human) namespace: protein def: "A POU domain, class 6, transcription factor 2 that is encoded in the genome of human." [PRO:DNx, UniProtKB:P78424] comment: Category=organism-gene. synonym: "hPOU6F2" EXACT PRO-short-label [PRO:DNx] synonym: "POU6F2" RELATED Gene-based [UniProtKB:P78424] synonym: "retina-derived POU domain factor 1 (human)" EXACT [UniProtKB:P78424] synonym: "RPF-1 (human)" EXACT [UniProtKB:P78424] synonym: "RPF1" RELATED Gene-based [UniProtKB:P78424] xref: UniProtKB:P78424 is_a: PR:000013047 ! POU domain, class 6, transcription factor 2 is_a: PR:000029067 ! Homo sapiens protein intersection_of: PR:000013047 ! POU domain, class 6, transcription factor 2 intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:P78509 name: reelin (human) namespace: protein def: "A reelin that is encoded in the genome of human." [PRO:DNx, UniProtKB:P78509] comment: Category=organism-gene. synonym: "hRELN" EXACT PRO-short-label [PRO:DNx] synonym: "RELN" RELATED Gene-based [UniProtKB:P78509] xref: UniProtKB:P78509 is_a: PR:000013879 ! reelin is_a: PR:000029067 ! Homo sapiens protein intersection_of: PR:000013879 ! reelin intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:P80188 name: neutrophil gelatinase-associated lipocalin (human) namespace: protein def: "A neutrophil gelatinase-associated lipocalin that is encoded in the genome of human." [PRO:DNx, UniProtKB:P80188] comment: Category=organism-gene. synonym: "25 kDa alpha-2-microglobulin-related subunit of MMP-9 (human)" EXACT [UniProtKB:P80188] synonym: "hLCN2" EXACT PRO-short-label [PRO:DNx] synonym: "HNL" RELATED Gene-based [UniProtKB:P80188] synonym: "LCN2" RELATED Gene-based [UniProtKB:P80188] synonym: "lipocalin-2 (human)" EXACT [UniProtKB:P80188] synonym: "NGAL" RELATED Gene-based [UniProtKB:P80188] synonym: "oncogene 24p3 (human)" EXACT [UniProtKB:P80188] synonym: "p25 (human)" BROAD [UniProtKB:P80188] synonym: "siderocalin (human)" EXACT [UniProtKB:P80188] xref: UniProtKB:P80188 is_a: PR:000009725 ! neutrophil gelatinase-associated lipocalin is_a: PR:000029067 ! Homo sapiens protein intersection_of: PR:000009725 ! neutrophil gelatinase-associated lipocalin intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:P97367 name: homeobox protein Meis2 (mouse) namespace: protein def: "A homeobox protein Meis2 that is encoded in the genome of mouse." [OMA:P97367, PRO:DNx] comment: Category=organism-gene. synonym: "Meis1-related protein 1 (mouse)" EXACT [UniProtKB:P97367] synonym: "Meis2" RELATED Gene-based [UniProtKB:P97367] synonym: "mMEIS2" EXACT PRO-short-label [PRO:DNx] synonym: "Mrg1" RELATED Gene-based [UniProtKB:P97367] synonym: "Stra10" RELATED Gene-based [UniProtKB:P97367] xref: UniProtKB:P97367 is_a: PR:000010317 ! homeobox protein Meis2 is_a: PR:000029032 ! Mus musculus protein intersection_of: PR:000010317 ! homeobox protein Meis2 intersection_of: RO:0002160 NCBITaxon:10090 ! only in taxon Mus musculus [Term] id: PR:P97449 name: aminopeptidase N (mouse) namespace: protein def: "An aminopeptidase N that is encoded in the genome of mouse." [OMA:P97449, PRO:DNx] comment: Category=organism-gene. synonym: "alanyl aminopeptidase (mouse)" EXACT [UniProtKB:P97449] synonym: "aminopeptidase M (mouse)" EXACT [UniProtKB:P97449] synonym: "Anpep" RELATED Gene-based [UniProtKB:P97449] synonym: "AP-M (mouse)" EXACT [UniProtKB:P97449] synonym: "AP-N (mouse)" EXACT [UniProtKB:P97449] synonym: "CD13 (mouse)" EXACT [UniProtKB:P97449] synonym: "Lap-1" RELATED Gene-based [UniProtKB:P97449] synonym: "Lap1" RELATED Gene-based [UniProtKB:P97449] synonym: "mANPEP" EXACT PRO-short-label [PRO:DNx] synonym: "mAPN" EXACT [UniProtKB:P97449] synonym: "membrane protein p161 (mouse)" EXACT [UniProtKB:P97449] synonym: "microsomal aminopeptidase (mouse)" EXACT [UniProtKB:P97449] xref: UniProtKB:P97449 is_a: PR:000002031 ! aminopeptidase N is_a: PR:000029032 ! Mus musculus protein intersection_of: PR:000002031 ! aminopeptidase N intersection_of: RO:0002160 NCBITaxon:10090 ! only in taxon Mus musculus [Term] id: PR:P97797 name: tyrosine-protein phosphatase non-receptor type substrate 1 (mouse) namespace: protein def: "A tyrosine-protein phosphatase non-receptor type substrate 1 that is encoded in the genome of mouse." [PRO:DAN] comment: Category=organism-gene. synonym: "Bit" RELATED Gene-based [UniProtKB:P97797] synonym: "brain Ig-like molecule with tyrosine-based activation motifs (mouse)" EXACT [UniProtKB:P97797] synonym: "CD172 antigen-like family member A (mouse)" EXACT [UniProtKB:P97797] synonym: "CD172a (mouse)" EXACT [UniProtKB:P97797] synonym: "inhibitory receptor SHPS-1 (mouse)" EXACT [UniProtKB:P97797] synonym: "mSIRP-alpha1" EXACT [UniProtKB:P97797] synonym: "mSIRPA" EXACT PRO-short-label [PRO:DNx] synonym: "MyD-1 antigen (mouse)" EXACT [UniProtKB:P97797] synonym: "Myd1" RELATED Gene-based [UniProtKB:P97797] synonym: "p84 (mouse)" BROAD [UniProtKB:P97797] synonym: "Ptpns1" RELATED Gene-based [UniProtKB:P97797] synonym: "SHP substrate 1 (mouse)" EXACT [UniProtKB:P97797] synonym: "SHPS-1 (mouse)" EXACT [UniProtKB:P97797] synonym: "Shps1" RELATED Gene-based [UniProtKB:P97797] synonym: "signal-regulatory protein alpha-1 (mouse)" EXACT [UniProtKB:P97797] synonym: "Sirp" RELATED Gene-based [UniProtKB:P97797] synonym: "Sirp-alpha-1 (mouse)" EXACT [UniProtKB:P97797] synonym: "Sirpa" RELATED Gene-based [UniProtKB:P97797] xref: UniProtKB:P97797 is_a: PR:000001968 ! tyrosine-protein phosphatase non-receptor type substrate 1 is_a: PR:000029032 ! Mus musculus protein intersection_of: PR:000001968 ! tyrosine-protein phosphatase non-receptor type substrate 1 intersection_of: RO:0002160 NCBITaxon:10090 ! only in taxon Mus musculus [Term] id: PR:P97926 name: oxytocin receptor (mouse) namespace: protein def: "An oxytocin receptor that is encoded in the genome of mouse." [OMA:P97926, PRO:DNx] comment: Category=organism-gene. synonym: "mOXTR" EXACT PRO-short-label [PRO:DNx] synonym: "OT-R (mouse)" EXACT [UniProtKB:P97926] synonym: "Oxtr" RELATED Gene-based [UniProtKB:P97926] xref: UniProtKB:P97926 is_a: PR:000001635 ! oxytocin receptor is_a: PR:000029032 ! Mus musculus protein intersection_of: PR:000001635 ! oxytocin receptor intersection_of: RO:0002160 NCBITaxon:10090 ! only in taxon Mus musculus [Term] id: PR:Q00342 name: receptor-type tyrosine-protein kinase FLT3 (mouse) namespace: protein def: "A receptor-type tyrosine-protein kinase FLT3 that is encoded in the genome of mouse." [OMA:Q00342, PRO:DNx] comment: Category=organism-gene. synonym: "CD135 (mouse)" EXACT [UniProtKB:Q00342] synonym: "fetal liver kinase 2 (mouse)" EXACT [UniProtKB:Q00342] synonym: "FL cytokine receptor (mouse)" EXACT [UniProtKB:Q00342] synonym: "Flk-2" RELATED Gene-based [UniProtKB:Q00342] synonym: "FLK-2 (mouse)" EXACT [UniProtKB:Q00342] synonym: "Flt-3" RELATED Gene-based [UniProtKB:Q00342] synonym: "FLT-3 (mouse)" EXACT [UniProtKB:Q00342] synonym: "Flt3" RELATED Gene-based [UniProtKB:Q00342] synonym: "fms-like tyrosine kinase 3 (mouse)" EXACT [UniProtKB:Q00342] synonym: "mFLT3" EXACT PRO-short-label [PRO:DNx] synonym: "tyrosine-protein kinase receptor flk-2 (mouse)" EXACT [UniProtKB:Q00342] xref: UniProtKB:Q00342 is_a: PR:000002001 ! receptor-type tyrosine-protein kinase FLT3 is_a: PR:000029032 ! Mus musculus protein intersection_of: PR:000002001 ! receptor-type tyrosine-protein kinase FLT3 intersection_of: RO:0002160 NCBITaxon:10090 ! only in taxon Mus musculus [Term] id: PR:Q00609 name: T-lymphocyte activation antigen CD80 (mouse) namespace: protein def: "A CD80 molecule that is encoded in the genome of mouse." [OMA:Q00609, PRO:DNx] comment: Category=organism-gene. synonym: "activation B7-1 antigen (mouse)" EXACT [UniProtKB:Q00609] synonym: "B7" RELATED Gene-based [UniProtKB:Q00609] synonym: "Cd80" RELATED Gene-based [UniProtKB:Q00609] synonym: "CD80 (mouse)" EXACT [UniProtKB:Q00609] synonym: "mCD80" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:Q00609 is_a: PR:000001438 ! CD80 molecule is_a: PR:000029032 ! Mus musculus protein intersection_of: PR:000001438 ! CD80 molecule intersection_of: RO:0002160 NCBITaxon:10090 ! only in taxon Mus musculus [Term] id: PR:Q00651 name: integrin alpha-4 (mouse) namespace: protein def: "An integrin alpha-4 that is encoded in the genome of mouse." [OMA:Q00651, PRO:DNx] comment: Category=organism-gene. synonym: "CD49 antigen-like family member D (mouse)" EXACT [UniProtKB:Q00651] synonym: "CD49d (mouse)" EXACT [UniProtKB:Q00651] synonym: "integrin alpha-IV (mouse)" EXACT [UniProtKB:Q00651] synonym: "Itga4" RELATED Gene-based [UniProtKB:Q00651] synonym: "LPAM subunit alpha (mouse)" EXACT [UniProtKB:Q00651] synonym: "lymphocyte Peyer patch adhesion molecules subunit alpha (mouse)" EXACT [UniProtKB:Q00651] synonym: "mITGA4" EXACT PRO-short-label [PRO:DNx] synonym: "VLA-4 subunit alpha (mouse)" EXACT [UniProtKB:Q00651] xref: UniProtKB:Q00651 is_a: PR:000009129 ! integrin alpha-4 is_a: PR:000029032 ! Mus musculus protein intersection_of: PR:000009129 ! integrin alpha-4 intersection_of: RO:0002160 NCBITaxon:10090 ! only in taxon Mus musculus [Term] id: PR:Q00653 name: nuclear factor NF-kappa-B p100 subunit (human) namespace: protein def: "A nuclear factor NF-kappa-B p100 subunit that is encoded in the genome of human." [PRO:DNx, UniProtKB:Q00653] comment: Category=organism-gene. synonym: "DNA-binding factor KBF2 (human)" EXACT [UniProtKB:Q00653] synonym: "H2TF1 (human)" EXACT [UniProtKB:Q00653] synonym: "hNFKB2" EXACT PRO-short-label [PRO:DNx] synonym: "lymphocyte translocation chromosome 10 protein (human)" EXACT [UniProtKB:Q00653] synonym: "LYT10" RELATED Gene-based [UniProtKB:Q00653] synonym: "NFKB2" RELATED Gene-based [UniProtKB:Q00653] synonym: "nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (human)" EXACT [UniProtKB:Q00653] synonym: "oncogene Lyt-10 (human)" EXACT [UniProtKB:Q00653] xref: Reactome:R-HSA-2677931 "PR:Q00653 located_in GO:0005829" xref: UniProtKB:Q00653 is_a: PR:000011178 ! nuclear factor NF-kappa-B p100 subunit is_a: PR:000029067 ! Homo sapiens protein intersection_of: PR:000011178 ! nuclear factor NF-kappa-B p100 subunit intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:Q00993 name: tyrosine-protein kinase receptor UFO (mouse) namespace: protein def: "A tyrosine-protein kinase receptor UFO that is encoded in the genome of mouse." [OMA:Q00993, PRO:DNx] comment: Category=organism-gene. synonym: "adhesion-related kinase (mouse)" EXACT [UniProtKB:Q00993] synonym: "Ark" RELATED Gene-based [UniProtKB:Q00993] synonym: "Axl" RELATED Gene-based [UniProtKB:Q00993] synonym: "mAXL" EXACT PRO-short-label [PRO:DNx] synonym: "Ufo" RELATED Gene-based [UniProtKB:Q00993] xref: UniProtKB:Q00993 is_a: PR:000004528 ! tyrosine-protein kinase receptor UFO is_a: PR:000029032 ! Mus musculus protein intersection_of: PR:000004528 ! tyrosine-protein kinase receptor UFO intersection_of: RO:0002160 NCBITaxon:10090 ! only in taxon Mus musculus [Term] id: PR:Q01102 name: P-selectin (mouse) namespace: protein def: "A P-selectin that is encoded in the genome of mouse." [OMA:Q01102, PRO:DNx] comment: Category=organism-gene. synonym: "CD62 antigen-like family member P (mouse)" EXACT [UniProtKB:Q01102] synonym: "CD62P (mouse)" EXACT [UniProtKB:Q01102] synonym: "GMP-140 (mouse)" EXACT [UniProtKB:Q01102] synonym: "granule membrane protein 140 (mouse)" EXACT [UniProtKB:Q01102] synonym: "Grmp" RELATED Gene-based [UniProtKB:Q01102] synonym: "LECAM3 (mouse)" EXACT [UniProtKB:Q01102] synonym: "leukocyte-endothelial cell adhesion molecule 3 (mouse)" EXACT [UniProtKB:Q01102] synonym: "mSELP" EXACT PRO-short-label [PRO:DNx] synonym: "PADGEM (mouse)" EXACT [UniProtKB:Q01102] synonym: "platelet activation dependent granule-external membrane protein (mouse)" EXACT [UniProtKB:Q01102] synonym: "Selp" RELATED Gene-based [UniProtKB:Q01102] xref: UniProtKB:Q01102 is_a: PR:000001432 ! P-selectin is_a: PR:000029032 ! Mus musculus protein intersection_of: PR:000001432 ! P-selectin intersection_of: RO:0002160 NCBITaxon:10090 ! only in taxon Mus musculus [Term] id: PR:Q01151 name: CD83 antigen (human) namespace: protein def: "A CD83 molecule that is encoded in the genome of human." [PRO:WCB, UniProtKB:Q01151] comment: Category=organism-gene. synonym: "B-cell activation protein (human)" EXACT [UniProtKB:Q01151] synonym: "CD83" RELATED Gene-based [UniProtKB:Q01151] synonym: "cell surface protein HB15 (human)" EXACT [UniProtKB:Q01151] synonym: "hCD83" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:Q01151 is_a: PR:000001310 ! CD83 molecule is_a: PR:000029067 ! Homo sapiens protein intersection_of: PR:000001310 ! CD83 molecule intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:Q01196 name: runt-related transcription factor 1 (human) namespace: protein def: "A runt-related transcription factor 1 that is encoded in the genome of human." [PRO:PD] comment: Category=organism-gene. synonym: "acute myeloid leukemia 1 protein (human)" EXACT [UniProtKB:Q01196] synonym: "AML1" RELATED Gene-based [UniProtKB:Q01196] synonym: "CBF-alpha-2 (human)" EXACT [UniProtKB:Q01196] synonym: "CBFA2" RELATED Gene-based [UniProtKB:Q01196] synonym: "core-binding factor subunit alpha-2 (human)" EXACT [UniProtKB:Q01196] synonym: "hRUNX1" EXACT PRO-short-label [PRO:DNx] synonym: "oncogene AML-1 (human)" EXACT [UniProtKB:Q01196] synonym: "PEA2-alpha B (human)" EXACT [UniProtKB:Q01196] synonym: "PEBP2-alpha B (human)" EXACT [UniProtKB:Q01196] synonym: "polyomavirus enhancer-binding protein 2 alpha B subunit (human)" EXACT [UniProtKB:Q01196] synonym: "RUNX1" RELATED Gene-based [UniProtKB:Q01196] synonym: "SL3-3 enhancer factor 1 alpha B subunit (human)" EXACT [UniProtKB:Q01196] synonym: "SL3/AKV core-binding factor alpha B subunit (human)" EXACT [UniProtKB:Q01196] xref: Reactome:R-HSA-5667138 "PR:Q01196 located_in GO:0005886" xref: Reactome:R-HSA-8865295 "PR:Q01196 located_in GO:0005654" xref: UniProtKB:Q01196 is_a: PR:000014362 ! runt-related transcription factor 1 is_a: PR:000029067 ! Homo sapiens protein intersection_of: PR:000014362 ! runt-related transcription factor 1 intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:Q01344 name: interleukin-5 receptor subunit alpha (human) namespace: protein def: "An interleukin-5 receptor subunit alpha that is encoded in the genome of human." [PRO:WCB, UniProtKB:Q01344] comment: Category=organism-gene. synonym: "CD125 (human)" EXACT [UniProtKB:Q01344] synonym: "CDw125 (human)" EXACT [UniProtKB:Q01344] synonym: "hIL5RA" EXACT PRO-short-label [PRO:DNx] synonym: "IL-5 receptor subunit alpha (human)" EXACT [UniProtKB:Q01344] synonym: "IL-5R subunit alpha (human)" EXACT [UniProtKB:Q01344] synonym: "IL-5R-alpha (human)" EXACT [UniProtKB:Q01344] synonym: "IL-5RA (human)" EXACT [UniProtKB:Q01344] synonym: "IL5R" RELATED Gene-based [UniProtKB:Q01344] synonym: "IL5RA" RELATED Gene-based [UniProtKB:Q01344] xref: UniProtKB:Q01344 is_a: PR:000001867 ! interleukin-5 receptor subunit alpha is_a: PR:000029067 ! Homo sapiens protein intersection_of: PR:000001867 ! interleukin-5 receptor subunit alpha intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:Q01638 name: interleukin-1 receptor-like 1 (human) namespace: protein def: "An interleukin-1 receptor-like 1 that is encoded in the genome of human." [PRO:DNx, UniProtKB:Q01638] comment: Category=organism-gene. synonym: "DER4" RELATED Gene-based [UniProtKB:Q01638] synonym: "hIL1RL1" EXACT PRO-short-label [PRO:DNx] synonym: "IL1RL1" RELATED Gene-based [UniProtKB:Q01638] synonym: "protein ST2 (human)" EXACT [UniProtKB:Q01638] synonym: "ST2" RELATED Gene-based [UniProtKB:Q01638] synonym: "T1" RELATED Gene-based [UniProtKB:Q01638] xref: UniProtKB:Q01638 is_a: PR:000008994 ! interleukin-1 receptor-like 1 is_a: PR:000029067 ! Homo sapiens protein intersection_of: PR:000008994 ! interleukin-1 receptor-like 1 intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:Q01851 name: POU domain, class 4, transcription factor 1 (human) namespace: protein def: "A POU domain, class 4, transcription factor 1 that is encoded in the genome of human." [PRO:DNx, UniProtKB:Q01851] comment: Category=organism-gene. synonym: "brain-3A (human)" EXACT [UniProtKB:Q01851] synonym: "brain-specific homeobox/POU domain protein 3A (human)" EXACT [UniProtKB:Q01851] synonym: "Brn-3A (human)" EXACT [UniProtKB:Q01851] synonym: "BRN3A" RELATED Gene-based [UniProtKB:Q01851] synonym: "homeobox/POU domain protein RDC-1 (human)" EXACT [UniProtKB:Q01851] synonym: "hPOU4F1" EXACT PRO-short-label [PRO:DNx] synonym: "Oct-T1 (human)" EXACT [UniProtKB:Q01851] synonym: "POU4F1" RELATED Gene-based [UniProtKB:Q01851] synonym: "RDC1" RELATED Gene-based [UniProtKB:Q01851] xref: Reactome:R-HSA-6804391 "PR:Q01851 located_in GO:0005654" xref: UniProtKB:Q01851 is_a: PR:000013041 ! POU domain, class 4, transcription factor 1 is_a: PR:000029067 ! Homo sapiens protein intersection_of: PR:000013041 ! POU domain, class 4, transcription factor 1 intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:Q02242 name: programmed cell death protein 1 (mouse) namespace: protein def: "A programmed cell death protein 1 that is encoded in the genome of mouse." [OMA:Q02242, PRO:DNx] comment: Category=organism-gene. synonym: "CD279 (mouse)" EXACT [UniProtKB:Q02242] synonym: "mPD-1" EXACT [UniProtKB:Q02242] synonym: "mPDCD1" EXACT PRO-short-label [PRO:DNx] synonym: "Pd1" RELATED Gene-based [UniProtKB:Q02242] synonym: "Pdcd1" RELATED Gene-based [UniProtKB:Q02242] synonym: "protein PD-1 (mouse)" EXACT [UniProtKB:Q02242] xref: UniProtKB:Q02242 is_a: PR:000001919 ! programmed cell death protein 1 is_a: PR:000029032 ! Mus musculus protein intersection_of: PR:000001919 ! programmed cell death protein 1 intersection_of: RO:0002160 NCBITaxon:10090 ! only in taxon Mus musculus [Term] id: PR:Q02548 name: paired box protein Pax-5 (human) namespace: protein def: "A paired box protein PAX-5 that is encoded in the genome of human." [PRO:WCB, UniProtKB:Q02548] comment: Category=organism-gene. synonym: "B-cell-specific transcription factor (human)" EXACT [UniProtKB:Q02548] synonym: "BSAP (human)" EXACT [UniProtKB:Q02548] synonym: "hPAX5" EXACT PRO-short-label [PRO:DNx] synonym: "PAX5" RELATED Gene-based [UniProtKB:Q02548] xref: Reactome:R-HSA-158583 "PR:Q02548 located_in GO:0005654" xref: UniProtKB:Q02548 is_a: PR:000001903 ! paired box protein PAX-5 is_a: PR:000029067 ! Homo sapiens protein intersection_of: PR:000001903 ! paired box protein PAX-5 intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:Q02650 name: paired box protein Pax-5 (mouse) namespace: protein def: "A paired box protein PAX-5 that is encoded in the genome of mouse." [OMA:Q02650, PRO:DNx] comment: Category=organism-gene. synonym: "B-cell-specific transcription factor (mouse)" EXACT [UniProtKB:Q02650] synonym: "BSAP (mouse)" EXACT [UniProtKB:Q02650] synonym: "mPAX5" EXACT PRO-short-label [PRO:DNx] synonym: "Pax-5" RELATED Gene-based [UniProtKB:Q02650] synonym: "Pax5" RELATED Gene-based [UniProtKB:Q02650] xref: UniProtKB:Q02650 is_a: PR:000001903 ! paired box protein PAX-5 is_a: PR:000029032 ! Mus musculus protein intersection_of: PR:000001903 ! paired box protein PAX-5 intersection_of: RO:0002160 NCBITaxon:10090 ! only in taxon Mus musculus [Term] id: PR:Q03059 name: choline O-acetyltransferase (mouse) namespace: protein def: "A choline O-acetyltransferase that is encoded in the genome of mouse." [OMA:Q03059, PRO:DNx] comment: Category=organism-gene. synonym: "Chat" RELATED Gene-based [UniProtKB:Q03059] synonym: "ChAT (mouse)" EXACT [UniProtKB:Q03059] synonym: "CHOACTase (mouse)" EXACT [UniProtKB:Q03059] synonym: "choline acetylase (mouse)" EXACT [UniProtKB:Q03059] synonym: "mCHAT" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:Q03059 is_a: PR:000005404 ! choline O-acetyltransferase is_a: PR:000029032 ! Mus musculus protein intersection_of: PR:000005404 ! choline O-acetyltransferase intersection_of: RO:0002160 NCBITaxon:10090 ! only in taxon Mus musculus [Term] id: PR:Q03347 name: runt-related transcription factor 1 (mouse) namespace: protein def: "A runt-related transcription factor 1 that is encoded in the genome of mouse." [OMA:Q03347, PRO:DNx] comment: Category=organism-gene. synonym: "acute myeloid leukemia 1 protein (mouse)" EXACT [UniProtKB:Q03347] synonym: "Aml1" RELATED Gene-based [UniProtKB:Q03347] synonym: "CBF-alpha-2 (mouse)" EXACT [UniProtKB:Q03347] synonym: "Cbfa2" RELATED Gene-based [UniProtKB:Q03347] synonym: "core-binding factor subunit alpha-2 (mouse)" EXACT [UniProtKB:Q03347] synonym: "mRUNX1" EXACT PRO-short-label [PRO:DNx] synonym: "oncogene AML-1 (mouse)" EXACT [UniProtKB:Q03347] synonym: "PEA2-alpha B (mouse)" EXACT [UniProtKB:Q03347] synonym: "PEBP2-alpha B (mouse)" EXACT [UniProtKB:Q03347] synonym: "Pebp2ab" RELATED Gene-based [UniProtKB:Q03347] synonym: "polyomavirus enhancer-binding protein 2 alpha B subunit (mouse)" EXACT [UniProtKB:Q03347] synonym: "Runx1" RELATED Gene-based [UniProtKB:Q03347] synonym: "SL3-3 enhancer factor 1 alpha B subunit (mouse)" EXACT [UniProtKB:Q03347] synonym: "SL3/AKV core-binding factor alpha B subunit (mouse)" EXACT [UniProtKB:Q03347] xref: UniProtKB:Q03347 is_a: PR:000014362 ! runt-related transcription factor 1 is_a: PR:000029032 ! Mus musculus protein intersection_of: PR:000014362 ! runt-related transcription factor 1 intersection_of: RO:0002160 NCBITaxon:10090 ! only in taxon Mus musculus [Term] id: PR:Q03405 name: urokinase plasminogen activator surface receptor (human) namespace: protein def: "A urokinase plasminogen activator surface receptor that is encoded in the genome of human." [PRO:WCB, UniProtKB:Q03405] comment: Category=organism-gene. synonym: "CD87 (human)" EXACT [UniProtKB:Q03405] synonym: "hPLAUR" EXACT PRO-short-label [PRO:DNx] synonym: "MO3" RELATED Gene-based [UniProtKB:Q03405] synonym: "monocyte activation antigen Mo3 (human)" EXACT [UniProtKB:Q03405] synonym: "PLAUR" RELATED Gene-based [UniProtKB:Q03405] synonym: "U-PAR (human)" EXACT [UniProtKB:Q03405] synonym: "UPAR" RELATED Gene-based [UniProtKB:Q03405] xref: UniProtKB:Q03405 is_a: PR:000001969 ! urokinase plasminogen activator surface receptor is_a: PR:000029067 ! Homo sapiens protein intersection_of: PR:000001969 ! urokinase plasminogen activator surface receptor intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:Q03692 name: collagen alpha-1(X) chain (human) namespace: protein def: "A collagen alpha-1(X) chain that is encoded in the genome of human." [PRO:DNx, UniProtKB:Q03692] comment: Category=organism-gene. synonym: "COL10A1" RELATED Gene-based [UniProtKB:Q03692] synonym: "hCOL10A1" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:Q03692 is_a: PR:000005693 ! collagen alpha-1(X) chain is_a: PR:000029067 ! Homo sapiens protein intersection_of: PR:000005693 ! collagen alpha-1(X) chain intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:Q04683 name: C-X-C chemokine receptor type 5 (mouse) namespace: protein def: "A C-X-C chemokine receptor type 5 that is encoded in the genome of mouse." [OMA:Q04683, PRO:DNx] comment: Category=organism-gene. synonym: "Blr1" RELATED Gene-based [UniProtKB:Q04683] synonym: "burkitt lymphoma receptor 1 homolog (mouse)" EXACT [UniProtKB:Q04683] synonym: "CD185 (mouse)" EXACT [UniProtKB:Q04683] synonym: "CXC-R5 (mouse)" EXACT [UniProtKB:Q04683] synonym: "CXCR-5 (mouse)" EXACT [UniProtKB:Q04683] synonym: "Cxcr5" RELATED Gene-based [UniProtKB:Q04683] synonym: "Gpcr6" RELATED Gene-based [UniProtKB:Q04683] synonym: "mCXCR5" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:Q04683 is_a: PR:000001209 ! C-X-C chemokine receptor type 5 is_a: PR:000029032 ! Mus musculus protein intersection_of: PR:000001209 ! C-X-C chemokine receptor type 5 intersection_of: RO:0002160 NCBITaxon:10090 ! only in taxon Mus musculus [Term] id: PR:Q04857 name: collagen alpha-1(VI) chain (mouse) namespace: protein def: "A collagen alpha-1(VI) chain that is encoded in the genome of mouse." [OMA:Q04857, PRO:DNx] comment: Category=organism-gene. synonym: "Col6a1" RELATED Gene-based [UniProtKB:Q04857] synonym: "mCOL6A1" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:Q04857 is_a: PR:000003353 ! collagen alpha-1(VI) chain is_a: PR:000029032 ! Mus musculus protein intersection_of: PR:000003353 ! collagen alpha-1(VI) chain intersection_of: RO:0002160 NCBITaxon:10090 ! only in taxon Mus musculus [Term] id: PR:Q05117 name: tartrate-resistant acid phosphatase type 5 (mouse) namespace: protein def: "A tartrate-resistant acid phosphatase type 5 that is encoded in the genome of mouse." [OMA:Q05117, PRO:DNx] comment: Category=organism-gene. synonym: "Acp5" RELATED Gene-based [UniProtKB:Q05117] synonym: "mACP5" EXACT PRO-short-label [PRO:DNx] synonym: "T5ap" RELATED Gene-based [UniProtKB:Q05117] synonym: "tartrate-resistant acid ATPase (mouse)" EXACT [UniProtKB:Q05117] synonym: "TR-AP (mouse)" EXACT [UniProtKB:Q05117] synonym: "Trap" RELATED Gene-based [UniProtKB:Q05117] synonym: "TrATPase (mouse)" EXACT [UniProtKB:Q05117] synonym: "type 5 acid phosphatase (mouse)" EXACT [UniProtKB:Q05117] xref: UniProtKB:Q05117 is_a: PR:000001937 ! tartrate-resistant acid phosphatase type 5 is_a: PR:000029032 ! Mus musculus protein intersection_of: PR:000001937 ! tartrate-resistant acid phosphatase type 5 intersection_of: RO:0002160 NCBITaxon:10090 ! only in taxon Mus musculus [Term] id: PR:Q05306 name: collagen alpha-1(X) chain (mouse) namespace: protein def: "A collagen alpha-1(X) chain that is encoded in the genome of mouse." [OMA:Q05306, PRO:DNx] comment: Category=organism-gene. synonym: "Col10a1" RELATED Gene-based [UniProtKB:Q05306] synonym: "mCOL10A1" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:Q05306 is_a: PR:000005693 ! collagen alpha-1(X) chain is_a: PR:000029032 ! Mus musculus protein intersection_of: PR:000005693 ! collagen alpha-1(X) chain intersection_of: RO:0002160 NCBITaxon:10090 ! only in taxon Mus musculus [Term] id: PR:Q06318 name: uteroglobin (mouse) namespace: protein def: "A uteroglobin that is encoded in the genome of mouse." [OMA:Q06318, PRO:DNx] comment: Category=organism-gene. synonym: "Cc10" RELATED Gene-based [UniProtKB:Q06318] synonym: "CC10 (mouse)" EXACT [UniProtKB:Q06318] synonym: "CCPBP (mouse)" EXACT [UniProtKB:Q06318] synonym: "Club cell 17 kDa protein (mouse)" EXACT [UniProtKB:Q06318] synonym: "Club cell phospholipid-binding protein (mouse)" EXACT [UniProtKB:Q06318] synonym: "Club cells 10 kDa secretory protein (mouse)" EXACT [UniProtKB:Q06318] synonym: "mSCGB1A1" EXACT PRO-short-label [PRO:DNx] synonym: "PCB-binding protein (mouse)" EXACT [UniProtKB:Q06318] synonym: "Scgb1a1" RELATED Gene-based [UniProtKB:Q06318] synonym: "secretoglobin family 1A member 1 (mouse)" EXACT [UniProtKB:Q06318] synonym: "Ugb" RELATED Gene-based [UniProtKB:Q06318] synonym: "Utg" RELATED Gene-based [UniProtKB:Q06318] xref: UniProtKB:Q06318 is_a: PR:000014505 ! uteroglobin is_a: PR:000029032 ! Mus musculus protein intersection_of: PR:000014505 ! uteroglobin intersection_of: RO:0002160 NCBITaxon:10090 ! only in taxon Mus musculus [Term] id: PR:Q07075 name: glutamyl aminopeptidase (human) namespace: protein def: "A glutamyl aminopeptidase that is encoded in the genome of human." [PRO:WCB, UniProtKB:Q07075] comment: Category=organism-gene. synonym: "aminopeptidase A (human)" EXACT [UniProtKB:Q07075] synonym: "AP-A (human)" EXACT [UniProtKB:Q07075] synonym: "CD249 (human)" EXACT [UniProtKB:Q07075] synonym: "differentiation antigen gp160 (human)" EXACT [UniProtKB:Q07075] synonym: "EAP (human)" BROAD [UniProtKB:Q07075] synonym: "ENPEP" RELATED Gene-based [UniProtKB:Q07075] synonym: "hENPEP" EXACT PRO-short-label [PRO:DNx] xref: Reactome:R-HSA-2022341 "PR:Q07075 located_in GO:0005886" xref: UniProtKB:Q07075 is_a: PR:000002039 ! glutamyl aminopeptidase is_a: PR:000029067 ! Homo sapiens protein intersection_of: PR:000002039 ! glutamyl aminopeptidase intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:Q07108 name: early activation antigen CD69 (human) namespace: protein def: "A CD69 molecule that is encoded in the genome of human." [PRO:CNA, UniProtKB:Q07108] comment: Category=organism-gene. synonym: "activation inducer molecule (human)" EXACT [UniProtKB:Q07108] synonym: "AIM (human)" EXACT [UniProtKB:Q07108] synonym: "BL-AC/P26 (human)" EXACT [UniProtKB:Q07108] synonym: "C-type lectin domain family 2 member C (human)" EXACT [UniProtKB:Q07108] synonym: "CD69" RELATED Gene-based [UniProtKB:Q07108] synonym: "CLEC2C" RELATED Gene-based [UniProtKB:Q07108] synonym: "EA1 (human)" EXACT [UniProtKB:Q07108] synonym: "early T-cell activation antigen p60 (human)" EXACT [UniProtKB:Q07108] synonym: "GP32/28 (human)" EXACT [UniProtKB:Q07108] synonym: "hCD69" EXACT PRO-short-label [PRO:DNx] synonym: "leukocyte surface antigen Leu-23 (human)" EXACT [UniProtKB:Q07108] synonym: "MLR-3 (human)" EXACT [UniProtKB:Q07108] xref: UniProtKB:Q07108 is_a: PR:000001343 ! CD69 molecule is_a: PR:000029067 ! Homo sapiens protein intersection_of: PR:000001343 ! CD69 molecule intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:Q07763 name: natural killer cell receptor 2B4 (mouse) namespace: protein def: "A natural killer cell receptor 2B4 that is encoded in the genome of mouse." [OMA:Q07763, PRO:DNx] comment: Category=organism-gene. synonym: "2b4" RELATED Gene-based [UniProtKB:Q07763] synonym: "Cd244" RELATED Gene-based [UniProtKB:Q07763] synonym: "CD244 (mouse)" EXACT [UniProtKB:Q07763] synonym: "mCD244" EXACT PRO-short-label [PRO:DNx] synonym: "NK cell type I receptor protein 2B4 (mouse)" EXACT [UniProtKB:Q07763] synonym: "NKR2B4 (mouse)" EXACT [UniProtKB:Q07763] synonym: "Nmrk" RELATED Gene-based [UniProtKB:Q07763] synonym: "non-MHC restricted killing associated (mouse)" EXACT [UniProtKB:Q07763] synonym: "signaling lymphocytic activation molecule 4 (mouse)" EXACT [UniProtKB:Q07763] synonym: "SLAM family member 4 (mouse)" EXACT [UniProtKB:Q07763] synonym: "SLAMF4 (mouse)" EXACT [UniProtKB:Q07763] xref: UniProtKB:Q07763 is_a: PR:000001896 ! natural killer cell receptor 2B4 is_a: PR:000029032 ! Mus musculus protein intersection_of: PR:000001896 ! natural killer cell receptor 2B4 intersection_of: RO:0002160 NCBITaxon:10090 ! only in taxon Mus musculus [Term] id: PR:Q08857 name: platelet glycoprotein 4 (mouse) namespace: protein def: "A platelet glycoprotein 4 that is encoded in the genome of mouse." [OMA:Q08857, PRO:DNx] comment: Category=organism-gene. synonym: "Cd36" RELATED Gene-based [UniProtKB:Q08857] synonym: "CD36 (mouse)" EXACT [UniProtKB:Q08857] synonym: "glycoprotein IIIb (mouse)" EXACT [UniProtKB:Q08857] synonym: "GPIIIB (mouse)" EXACT [UniProtKB:Q08857] synonym: "GPIV (mouse)" EXACT [UniProtKB:Q08857] synonym: "mCD36" EXACT PRO-short-label [PRO:DNx] synonym: "PAS IV (mouse)" EXACT [UniProtKB:Q08857] synonym: "PAS-4 (mouse)" EXACT [UniProtKB:Q08857] synonym: "platelet glycoprotein IV (mouse)" EXACT [UniProtKB:Q08857] xref: UniProtKB:Q08857 is_a: PR:000001905 ! platelet glycoprotein 4 is_a: PR:000029032 ! Mus musculus protein intersection_of: PR:000001905 ! platelet glycoprotein 4 intersection_of: RO:0002160 NCBITaxon:10090 ! only in taxon Mus musculus [Term] id: PR:Q10589 name: bone marrow stromal antigen 2 (human) namespace: protein def: "A bone marrow stromal antigen 2 that is encoded in the genome of human." [PRO:WCB, UniProtKB:Q10589] comment: Category=organism-gene. synonym: "BST-2 (human)" EXACT [UniProtKB:Q10589] synonym: "BST2" RELATED Gene-based [UniProtKB:Q10589] synonym: "CD317 (human)" EXACT [UniProtKB:Q10589] synonym: "hBST2" EXACT PRO-short-label [PRO:DNx] synonym: "HM1.24 antigen (human)" EXACT [UniProtKB:Q10589] synonym: "tetherin (human)" EXACT [UniProtKB:Q10589] xref: UniProtKB:Q10589 is_a: PR:000001326 ! bone marrow stromal antigen 2 is_a: PR:000029067 ! Homo sapiens protein intersection_of: PR:000001326 ! bone marrow stromal antigen 2 intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:Q11127 name: alpha-(1,3)-fucosyltransferase 4 (mouse) namespace: protein def: "An alpha-(1,3)-fucosyltransferase 4 that is encoded in the genome of mouse." [OMA:Q11127, PRO:DNx] comment: Category=organism-gene. synonym: "4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase (mouse)" EXACT [UniProtKB:Q11127] synonym: "Elft" RELATED Gene-based [UniProtKB:Q11127] synonym: "Fuc-TIV (mouse)" EXACT [UniProtKB:Q11127] synonym: "fucosyltransferase 4 (mouse)" EXACT [UniProtKB:Q11127] synonym: "fucosyltransferase IV (mouse)" EXACT [UniProtKB:Q11127] synonym: "FucT-IV (mouse)" EXACT [UniProtKB:Q11127] synonym: "Fut4" RELATED Gene-based [UniProtKB:Q11127] synonym: "galactoside 3-L-fucosyltransferase (mouse)" EXACT [UniProtKB:Q11127] synonym: "mFUT4" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:Q11127 is_a: PR:000001456 ! alpha-(1,3)-fucosyltransferase 4 is_a: PR:000029032 ! Mus musculus protein intersection_of: PR:000001456 ! alpha-(1,3)-fucosyltransferase 4 intersection_of: RO:0002160 NCBITaxon:10090 ! only in taxon Mus musculus [Term] id: PR:Q12866 name: tyrosine-protein kinase Mer (human) namespace: protein def: "A tyrosine-protein kinase Mer that is encoded in the genome of human." [PRO:DNx, UniProtKB:Q12866] comment: Category=organism-gene. synonym: "hMERTK" EXACT PRO-short-label [PRO:DNx] synonym: "MER" RELATED Gene-based [UniProtKB:Q12866] synonym: "MERTK" RELATED Gene-based [UniProtKB:Q12866] synonym: "proto-oncogene c-Mer (human)" EXACT [UniProtKB:Q12866] synonym: "receptor tyrosine kinase MerTK (human)" EXACT [UniProtKB:Q12866] xref: DTO:03100312 xref: UniProtKB:Q12866 is_a: PR:000010329 ! tyrosine-protein kinase Mer is_a: PR:000029067 ! Homo sapiens protein intersection_of: PR:000010329 ! tyrosine-protein kinase Mer intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:Q12918 name: killer cell lectin-like receptor subfamily B member 1 (human) namespace: protein def: "A killer cell lectin-like receptor subfamily B member 1 that is encoded in the genome of human." [PRO:DAN] comment: Category=organism-gene. synonym: "C-type lectin domain family 5 member B (human)" EXACT [UniProtKB:Q12918] synonym: "CD161 (human)" EXACT [UniProtKB:Q12918] synonym: "CLEC5B" RELATED Gene-based [UniProtKB:Q12918] synonym: "hKLRB1" EXACT PRO-short-label [PRO:DNx] synonym: "HNKR-P1a (human)" EXACT [UniProtKB:Q12918] synonym: "KLRB1" RELATED Gene-based [UniProtKB:Q12918] synonym: "natural killer cell surface protein P1A (human)" EXACT [UniProtKB:Q12918] synonym: "NKR-P1A (human)" EXACT [UniProtKB:Q12918] synonym: "NKRP1A" RELATED Gene-based [UniProtKB:Q12918] xref: Reactome:R-HSA-2132225 "PR:Q12918 located_in GO:0005886" xref: UniProtKB:Q12918 is_a: PR:000025670 ! killer cell lectin-like receptor subfamily B member 1 is_a: PR:000029067 ! Homo sapiens protein intersection_of: PR:000025670 ! killer cell lectin-like receptor subfamily B member 1 intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:Q13241 name: natural killer cells antigen CD94 (human) namespace: protein def: "A killer cell lectin-like receptor subfamily D member 1 that is encoded in the genome of human." [PRO:WCB, UniProtKB:Q13241] comment: Category=organism-gene. synonym: "CD94" RELATED Gene-based [UniProtKB:Q13241] synonym: "hKLRD1" EXACT PRO-short-label [PRO:DNx] synonym: "killer cell lectin-like receptor subfamily D member 1 (human)" EXACT [UniProtKB:Q13241] synonym: "KLRD1" RELATED Gene-based [UniProtKB:Q13241] synonym: "KP43 (human)" EXACT [UniProtKB:Q13241] synonym: "NK cell receptor (human)" EXACT [UniProtKB:Q13241] xref: Reactome:R-HSA-2326854 "PR:Q13241 located_in GO:0005886" xref: UniProtKB:Q13241 is_a: PR:000001402 ! killer cell lectin-like receptor subfamily D member 1 is_a: PR:000029067 ! Homo sapiens protein intersection_of: PR:000001402 ! killer cell lectin-like receptor subfamily D member 1 intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:Q13291 name: signaling lymphocytic activation molecule (human) namespace: protein def: "A SLAM family member 1 that is encoded in the genome of human." [PRO:WCB, UniProtKB:Q13291] comment: Category=organism-gene. synonym: "CD150 (human)" EXACT [UniProtKB:Q13291] synonym: "CDw150 (human)" EXACT [UniProtKB:Q13291] synonym: "hSLAMF1" EXACT PRO-short-label [PRO:DNx] synonym: "IPO-3 (human)" EXACT [UniProtKB:Q13291] synonym: "SLAM" RELATED Gene-based [UniProtKB:Q13291] synonym: "SLAM family member 1 (human)" EXACT [UniProtKB:Q13291] synonym: "SLAMF1" RELATED Gene-based [UniProtKB:Q13291] xref: UniProtKB:Q13291 is_a: PR:000001833 ! SLAM family member 1 is_a: PR:000029067 ! Homo sapiens protein intersection_of: PR:000001833 ! SLAM family member 1 intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:Q13445 name: transmembrane emp24 domain-containing protein 1 (human) namespace: protein def: "A transmembrane emp24 domain-containing protein 1 that is encoded in the genome of human." [PRO:DNx, UniProtKB:Q13445] comment: Category=organism-gene. synonym: "hTMED1" EXACT PRO-short-label [PRO:DNx] synonym: "IL1RL1L" RELATED Gene-based [UniProtKB:Q13445] synonym: "IL1RL1LG" RELATED Gene-based [UniProtKB:Q13445] synonym: "interleukin-1 receptor-like 1 ligand (human)" EXACT [UniProtKB:Q13445] synonym: "p24 family protein gamma-1 (human)" EXACT [UniProtKB:Q13445] synonym: "p24gamma1 (human)" EXACT [UniProtKB:Q13445] synonym: "putative T1/ST2 receptor-binding protein (human)" EXACT [UniProtKB:Q13445] synonym: "TMED1" RELATED Gene-based [UniProtKB:Q13445] synonym: "Tp24 (human)" EXACT [UniProtKB:Q13445] xref: UniProtKB:Q13445 is_a: PR:000016401 ! transmembrane emp24 domain-containing protein 1 is_a: PR:000029067 ! Homo sapiens protein intersection_of: PR:000016401 ! transmembrane emp24 domain-containing protein 1 intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:Q14246 name: adhesion G protein-coupled receptor E1 (human) namespace: protein def: "An adhesion G protein-coupled receptor E1 that is encoded in the genome of human." [PRO:WCB, UniProtKB:Q14246] comment: Category=organism-gene. synonym: "ADGRE1" RELATED Gene-based [UniProtKB:Q14246] synonym: "EGF-like module receptor 1 (human)" EXACT [UniProtKB:Q14246] synonym: "EGF-like module-containing mucin-like hormone receptor-like 1 (human)" EXACT [] synonym: "EMR1" RELATED Gene-based [UniProtKB:Q14246] synonym: "EMR1 hormone receptor (human)" EXACT [UniProtKB:Q14246] synonym: "hADGRE1" EXACT PRO-short-label [PRO:DNx] synonym: "TM7LN3" RELATED Gene-based [UniProtKB:Q14246] xref: DTO:02100089 xref: UniProtKB:Q14246 is_a: PR:000001813 ! adhesion G protein-coupled receptor E1 is_a: PR:000029067 ! Homo sapiens protein intersection_of: PR:000001813 ! adhesion G protein-coupled receptor E1 intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:Q14515 name: SPARC-like protein 1 (human) namespace: protein def: "A SPARC-like protein 1 that is encoded in the genome of human." [PRO:DNx, UniProtKB:Q14515] comment: Category=organism-gene. synonym: "hevin (human)" EXACT [UniProtKB:Q14515] synonym: "high endothelial venule protein (human)" EXACT [UniProtKB:Q14515] synonym: "hSPARCL1" EXACT PRO-short-label [PRO:DNx] synonym: "MAST 9 (human)" EXACT [UniProtKB:Q14515] synonym: "SPARCL1" RELATED Gene-based [UniProtKB:Q14515] xref: UniProtKB:Q14515 is_a: PR:000015476 ! SPARC-like protein 1 is_a: PR:000029067 ! Homo sapiens protein intersection_of: PR:000015476 ! SPARC-like protein 1 intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:Q15063 name: periostin (human) namespace: protein def: "A periostin that is encoded in the genome of human." [PRO:DNx, UniProtKB:Q15063] comment: Category=organism-gene. synonym: "hPOSTN" EXACT PRO-short-label [PRO:DNx] synonym: "OSF-2 (human)" BROAD [UniProtKB:Q15063] synonym: "OSF2" RELATED Gene-based [UniProtKB:Q15063] synonym: "osteoblast-specific factor 2 (human)" EXACT [UniProtKB:Q15063] synonym: "PN (human)" EXACT [UniProtKB:Q15063] synonym: "POSTN" RELATED Gene-based [UniProtKB:Q15063] xref: UniProtKB:Q15063 is_a: PR:000013031 ! periostin is_a: PR:000029067 ! Homo sapiens protein intersection_of: PR:000013031 ! periostin intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:Q15116 name: programmed cell death protein 1 (human) namespace: protein def: "A programmed cell death protein 1 that is encoded in the genome of human." [PRO:WCB, UniProtKB:Q15116] comment: Category=organism-gene. synonym: "CD279 (human)" EXACT [UniProtKB:Q15116] synonym: "hPD-1" EXACT [UniProtKB:Q15116] synonym: "hPDCD1" EXACT PRO-short-label [PRO:DNx] synonym: "PD1" RELATED Gene-based [UniProtKB:Q15116] synonym: "PDCD1" RELATED Gene-based [UniProtKB:Q15116] synonym: "protein PD-1 (human)" EXACT [UniProtKB:Q15116] xref: UniProtKB:Q15116 is_a: PR:000001919 ! programmed cell death protein 1 is_a: PR:000029067 ! Homo sapiens protein intersection_of: PR:000001919 ! programmed cell death protein 1 intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:Q15465 name: sonic hedgehog protein (human) namespace: protein def: "A sonic hedgehog protein that is encoded in the genome of human." [PRO:DNx, UniProtKB:Q15465] comment: Category=organism-gene. synonym: "HHG-1 (human)" EXACT [UniProtKB:Q15465] synonym: "hSHH" EXACT PRO-short-label [PRO:DNx] synonym: "SHH" RELATED Gene-based [UniProtKB:Q15465] synonym: "Shh unprocessed N-terminal signaling and C-terminal autoprocessing domains (human)" EXACT [UniProtKB:Q15465] synonym: "ShhNC (human)" EXACT [UniProtKB:Q15465] xref: UniProtKB:Q15465 is_a: PR:000014841 ! sonic hedgehog protein is_a: PR:000029067 ! Homo sapiens protein intersection_of: PR:000014841 ! sonic hedgehog protein intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:Q15726 name: metastasis-suppressor KiSS-1 (human) namespace: protein def: "A metastasis-suppressor KiSS-1 that is encoded in the genome of human." [PRO:DNx, UniProtKB:Q15726] comment: Category=organism-gene. synonym: "hKISS1" EXACT PRO-short-label [PRO:DNx] synonym: "KISS1" RELATED Gene-based [UniProtKB:Q15726] synonym: "kisspeptin-1 (human)" EXACT [UniProtKB:Q15726] synonym: "PP5098" RELATED Gene-based [UniProtKB:Q15726] xref: UniProtKB:Q15726 is_a: PR:000009344 ! metastasis-suppressor KiSS-1 is_a: PR:000029067 ! Homo sapiens protein intersection_of: PR:000009344 ! metastasis-suppressor KiSS-1 intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:Q15744 name: CCAAT/enhancer-binding protein epsilon (human) namespace: protein def: "A CCAAT/enhancer-binding protein epsilon that is encoded in the genome of human." [PRO:DNx, UniProtKB:Q15744] comment: Category=organism-gene. synonym: "C/EBP epsilon (human)" EXACT [UniProtKB:Q15744] synonym: "CEBPE" RELATED Gene-based [UniProtKB:Q15744] synonym: "hCEBPE" EXACT PRO-short-label [PRO:DNx] xref: Reactome:R-HSA-3234072 "PR:Q15744 located_in GO:0005654" xref: UniProtKB:Q15744 is_a: PR:000005310 ! CCAAT/enhancer-binding protein epsilon is_a: PR:000029067 ! Homo sapiens protein intersection_of: PR:000005310 ! CCAAT/enhancer-binding protein epsilon intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:Q15858 name: sodium channel protein type 9 subunit alpha (human) namespace: protein def: "A sodium channel protein type 9 subunit alpha that is encoded in the genome of human." [PRO:WCB, UniProtKB:Q15858] comment: Category=organism-gene. synonym: "hNE-Na" EXACT [UniProtKB:Q15858] synonym: "hSCN9A" EXACT PRO-short-label [PRO:DNx] synonym: "NENA" RELATED Gene-based [UniProtKB:Q15858] synonym: "neuroendocrine sodium channel (human)" EXACT [UniProtKB:Q15858] synonym: "peripheral sodium channel 1 (human)" EXACT [UniProtKB:Q15858] synonym: "PN1 (human)" EXACT [UniProtKB:Q15858] synonym: "SCN9A" RELATED Gene-based [UniProtKB:Q15858] synonym: "sodium channel protein type IX subunit alpha (human)" EXACT [UniProtKB:Q15858] synonym: "voltage-gated sodium channel subunit alpha Nav1.7 (human)" EXACT [UniProtKB:Q15858] xref: DTO:01100300 xref: Reactome:R-HSA-443374 "PR:Q15858 located_in GO:0005886" xref: UniProtKB:Q15858 is_a: PR:000002104 ! sodium channel protein type 9 subunit alpha is_a: PR:000029067 ! Homo sapiens protein intersection_of: PR:000002104 ! sodium channel protein type 9 subunit alpha intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:Q16572 name: vesicular acetylcholine transporter (human) namespace: protein def: "A vesicular acetylcholine transporter that is encoded in the genome of human." [PRO:DNx, UniProtKB:Q16572] comment: Category=organism-gene. synonym: "hSLC18A3" EXACT PRO-short-label [PRO:DNx] synonym: "SLC18A3" RELATED Gene-based [UniProtKB:Q16572] synonym: "solute carrier family 18 member 3 (human)" EXACT [UniProtKB:Q16572] synonym: "VACHT" RELATED Gene-based [UniProtKB:Q16572] xref: Reactome:R-HSA-264619 "PR:Q16572 located_in GO:0060201" xref: Reactome:R-HSA-372513 "PR:Q16572 located_in GO:0005886" xref: Reactome:R-HSA-8869109 "PR:Q16572 located_in GO:0030665" xref: UniProtKB:Q16572 is_a: PR:000014968 ! vesicular acetylcholine transporter is_a: PR:000029067 ! Homo sapiens protein intersection_of: PR:000014968 ! vesicular acetylcholine transporter intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:Q16602 name: calcitonin gene-related peptide type 1 receptor (human) namespace: protein def: "A calcitonin gene-related peptide type 1 receptor that is encoded in the genome of human." [PRO:DNx, UniProtKB:Q16602] comment: Category=organism-gene. synonym: "calcitonin receptor-like receptor (human)" EXACT [UniProtKB:Q16602] synonym: "CALCRL" RELATED Gene-based [UniProtKB:Q16602] synonym: "CGRP type 1 receptor (human)" EXACT [UniProtKB:Q16602] synonym: "CGRPR" RELATED Gene-based [UniProtKB:Q16602] synonym: "CRLR (human)" EXACT [UniProtKB:Q16602] synonym: "hCALCRL" EXACT PRO-short-label [PRO:DNx] xref: DTO:02100049 xref: UniProtKB:Q16602 is_a: PR:000004973 ! calcitonin gene-related peptide type 1 receptor is_a: PR:000029067 ! Homo sapiens protein intersection_of: PR:000004973 ! calcitonin gene-related peptide type 1 receptor intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:Q18PI6 name: SLAM family member 5 (mouse) namespace: protein def: "A SLAM family member 5 that is encoded in the genome of mouse." [OMA:Q18PI6, PRO:DNx] comment: Category=organism-gene. synonym: "Cd84" RELATED Gene-based [UniProtKB:Q18PI6] synonym: "CD84 (mouse)" EXACT [UniProtKB:Q18PI6] synonym: "leukocyte differentiation antigen CD84 (mouse)" EXACT [UniProtKB:Q18PI6] synonym: "mCD84" EXACT PRO-short-label [PRO:DNx] synonym: "signaling lymphocytic activation molecule 5 (mouse)" EXACT [UniProtKB:Q18PI6] synonym: "Slamf5" RELATED Gene-based [UniProtKB:Q18PI6] xref: UniProtKB:Q18PI6 is_a: PR:000001319 ! SLAM family member 5 is_a: PR:000029032 ! Mus musculus protein intersection_of: PR:000001319 ! SLAM family member 5 intersection_of: RO:0002160 NCBITaxon:10090 ! only in taxon Mus musculus [Term] id: PR:Q2VLH6 name: scavenger receptor cysteine-rich type 1 protein M130 (mouse) namespace: protein def: "A scavenger receptor cysteine-rich type 1 protein M130 that is encoded in the genome of mouse." [OMA:Q2VLH6, PRO:DNx] comment: Category=organism-gene. synonym: "Cd163" RELATED Gene-based [UniProtKB:Q2VLH6] synonym: "CD163 (mouse)" EXACT [UniProtKB:Q2VLH6] synonym: "M130" RELATED Gene-based [UniProtKB:Q2VLH6] synonym: "mCD163" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:Q2VLH6 is_a: PR:000001925 ! scavenger receptor cysteine-rich type 1 protein M130 is_a: PR:000029032 ! Mus musculus protein intersection_of: PR:000001925 ! scavenger receptor cysteine-rich type 1 protein M130 intersection_of: RO:0002160 NCBITaxon:10090 ! only in taxon Mus musculus [Term] id: PR:Q3UR32 name: P2X purinoceptor 3 (mouse) namespace: protein def: "A P2X purinoceptor 3 that is encoded in the genome of mouse." [OMA:Q3UR32, PRO:DNx] comment: Category=organism-gene. synonym: "ATP receptor (mouse)" BROAD [UniProtKB:Q3UR32] synonym: "mP2RX3" EXACT PRO-short-label [PRO:DNx] synonym: "P2rx3" RELATED Gene-based [UniProtKB:Q3UR32] synonym: "P2X3 (mouse)" EXACT [UniProtKB:Q3UR32] synonym: "purinergic receptor (mouse)" BROAD [UniProtKB:Q3UR32] xref: UniProtKB:Q3UR32 is_a: PR:000012190 ! P2X purinoceptor 3 is_a: PR:000029032 ! Mus musculus protein intersection_of: PR:000012190 ! P2X purinoceptor 3 intersection_of: RO:0002160 NCBITaxon:10090 ! only in taxon Mus musculus [Term] id: PR:Q3V009 name: transmembrane emp24 domain-containing protein 1 (mouse) namespace: protein def: "A transmembrane emp24 domain-containing protein 1 that is encoded in the genome of mouse." [OMA:Q3V009, PRO:DNx] comment: Category=organism-gene. synonym: "Il1rl1l" RELATED Gene-based [UniProtKB:Q3V009] synonym: "interleukin-1 receptor-like 1 ligand (mouse)" EXACT [UniProtKB:Q3V009] synonym: "mTMED1" EXACT PRO-short-label [PRO:DNx] synonym: "p24 family protein gamma-1 (mouse)" EXACT [UniProtKB:Q3V009] synonym: "p24gamma1 (mouse)" EXACT [UniProtKB:Q3V009] synonym: "putative T1/ST2 receptor-binding protein (mouse)" EXACT [UniProtKB:Q3V009] synonym: "Tmed1" RELATED Gene-based [UniProtKB:Q3V009] xref: UniProtKB:Q3V009 is_a: PR:000016401 ! transmembrane emp24 domain-containing protein 1 is_a: PR:000029032 ! Mus musculus protein intersection_of: PR:000016401 ! transmembrane emp24 domain-containing protein 1 intersection_of: RO:0002160 NCBITaxon:10090 ! only in taxon Mus musculus [Term] id: PR:Q3V3R4 name: integrin alpha-1 (mouse) namespace: protein def: "An integrin alpha-1 that is encoded in the genome of mouse." [OMA:Q3V3R4, PRO:DNx] comment: Category=organism-gene. synonym: "CD49 antigen-like family member A (mouse)" EXACT [UniProtKB:Q3V3R4] synonym: "CD49a (mouse)" EXACT [UniProtKB:Q3V3R4] synonym: "Itga1" RELATED Gene-based [UniProtKB:Q3V3R4] synonym: "laminin and collagen receptor (mouse)" EXACT [UniProtKB:Q3V3R4] synonym: "mITGA1" EXACT PRO-short-label [PRO:DNx] synonym: "VLA-1 (mouse)" EXACT [UniProtKB:Q3V3R4] xref: UniProtKB:Q3V3R4 is_a: PR:000001007 ! integrin alpha-1 is_a: PR:000029032 ! Mus musculus protein intersection_of: PR:000001007 ! integrin alpha-1 intersection_of: RO:0002160 NCBITaxon:10090 ! only in taxon Mus musculus [Term] id: PR:Q5UKY4 name: cell surface glycoprotein CD200 receptor 3 (mouse) namespace: protein def: "A cell surface glycoprotein CD200 receptor 3 that is encoded in the genome of mouse." [PRO:DNx, UniProtKB:Q5UKY4] comment: Category=organism-gene. synonym: "CD200 cell surface glycoprotein receptor-like 3 (mouse)" EXACT [UniProtKB:Q5UKY4] synonym: "CD200 cell surface glycoprotein receptor-like b (mouse)" EXACT [UniProtKB:Q5UKY4] synonym: "CD200 receptor-like 3 (mouse)" EXACT [UniProtKB:Q5UKY4] synonym: "Cd200r3" RELATED Gene-based [UniProtKB:Q5UKY4] synonym: "Cd200rlb" RELATED Gene-based [UniProtKB:Q5UKY4] synonym: "cell surface glycoprotein OX2 receptor 3 (mouse)" EXACT [UniProtKB:Q5UKY4] synonym: "mCd200r3" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:Q5UKY4 is_a: PR:000006169 ! cell surface glycoprotein CD200 receptor 3 is_a: PR:000029032 ! Mus musculus protein intersection_of: PR:000006169 ! cell surface glycoprotein CD200 receptor 3 intersection_of: RO:0002160 NCBITaxon:10090 ! only in taxon Mus musculus [Term] id: PR:Q60651 name: killer cell lectin-like receptor 4 (mouse) namespace: protein def: "A killer cell lectin-like receptor 4 that is encoded in the genome of mouse." [PRO:DNx, UniProtKB:Q60651] comment: Category=organism-gene. synonym: "Klra4" RELATED Gene-based [UniProtKB:Q60651] synonym: "Ly-49d" RELATED Gene-based [UniProtKB:Q60651] synonym: "Ly49-d" RELATED Gene-based [UniProtKB:Q60651] synonym: "Ly49d" RELATED Gene-based [UniProtKB:Q60651] synonym: "lymphocyte antigen 49d (mouse)" EXACT [UniProtKB:Q60651] synonym: "mKlra4" EXACT PRO-short-label [PRO:DNx] synonym: "T-cell surface glycoprotein Ly-49D (mouse)" EXACT [UniProtKB:Q60651] xref: UniProtKB:Q60651 is_a: PR:000009619 ! killer cell lectin-like receptor 4 is_a: PR:000029032 ! Mus musculus protein intersection_of: PR:000009619 ! killer cell lectin-like receptor 4 intersection_of: RO:0002160 NCBITaxon:10090 ! only in taxon Mus musculus [Term] id: PR:Q60677 name: integrin alpha-E (mouse) namespace: protein def: "An integrin alpha-E that is encoded in the genome of mouse." [OMA:Q60677, PRO:DNx] comment: Category=organism-gene. synonym: "CD103 (mouse)" EXACT [UniProtKB:Q60677] synonym: "integrin alpha M290 (mouse)" EXACT [UniProtKB:Q60677] synonym: "Itgae" RELATED Gene-based [UniProtKB:Q60677] synonym: "mITGAE" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:Q60677 is_a: PR:000001010 ! integrin alpha-E is_a: PR:000029032 ! Mus musculus protein intersection_of: PR:000001010 ! integrin alpha-E intersection_of: RO:0002160 NCBITaxon:10090 ! only in taxon Mus musculus [Term] id: PR:Q60682 name: killer cell lectin-like receptor 8 (mouse) namespace: protein def: "A killer cell lectin-like receptor 8 that is encoded in the genome of mouse." [PRO:DNx, UniProtKB:Q60682] comment: Category=organism-gene. synonym: "Klra8" RELATED Gene-based [UniProtKB:Q60682] synonym: "Ly-49h" RELATED Gene-based [UniProtKB:Q60682] synonym: "Ly49-h" RELATED Gene-based [UniProtKB:Q60682] synonym: "Ly49H" RELATED Gene-based [UniProtKB:Q60682] synonym: "lymphocyte antigen 49h (mouse)" EXACT [UniProtKB:Q60682] synonym: "mKlra8" EXACT PRO-short-label [PRO:DNx] synonym: "T-cell surface glycoprotein Ly-49H (mouse)" EXACT [UniProtKB:Q60682] xref: UniProtKB:Q60682 is_a: PR:000009623 ! killer cell lectin-like receptor 8 is_a: PR:000029032 ! Mus musculus protein intersection_of: PR:000009623 ! killer cell lectin-like receptor 8 intersection_of: RO:0002160 NCBITaxon:10090 ! only in taxon Mus musculus [Term] id: PR:Q60754 name: macrophage receptor MARCO (mouse) namespace: protein def: "A macrophage receptor MARCO that is encoded in the genome of mouse." [OMA:Q60754, PRO:DNx] comment: Category=organism-gene. synonym: "macrophage receptor with collagenous structure (mouse)" EXACT [UniProtKB:Q60754] synonym: "Marco" RELATED Gene-based [UniProtKB:Q60754] synonym: "mMARCO" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:Q60754 is_a: PR:000001884 ! macrophage receptor MARCO is_a: PR:000029032 ! Mus musculus protein intersection_of: PR:000001884 ! macrophage receptor MARCO intersection_of: RO:0002160 NCBITaxon:10090 ! only in taxon Mus musculus [Term] id: PR:Q60767 name: lymphocyte antigen 75 (mouse) namespace: protein def: "A lymphocyte antigen 75 that is encoded in the genome of mouse." [PRO:DAN] comment: Category=organism-gene. synonym: "Cd205" RELATED Gene-based [UniProtKB:Q60767] synonym: "CD205 (mouse)" EXACT [UniProtKB:Q60767] synonym: "DEC-205 (mouse)" EXACT [UniProtKB:Q60767] synonym: "Ly-75 (mouse)" EXACT [UniProtKB:Q60767] synonym: "Ly75" RELATED Gene-based [UniProtKB:Q60767] synonym: "mLY75" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:Q60767 is_a: PR:000001026 ! lymphocyte antigen 75 is_a: PR:000029032 ! Mus musculus protein intersection_of: PR:000001026 ! lymphocyte antigen 75 intersection_of: RO:0002160 NCBITaxon:10090 ! only in taxon Mus musculus [Term] id: PR:Q60805 name: tyrosine-protein kinase Mer (mouse) namespace: protein def: "A tyrosine-protein kinase Mer that is encoded in the genome of mouse." [OMA:Q60805, PRO:DNx] comment: Category=organism-gene. synonym: "Mer" RELATED Gene-based [UniProtKB:Q60805] synonym: "Mertk" RELATED Gene-based [UniProtKB:Q60805] synonym: "mMERTK" EXACT PRO-short-label [PRO:DNx] synonym: "proto-oncogene c-Mer (mouse)" EXACT [UniProtKB:Q60805] synonym: "receptor tyrosine kinase MerTK (mouse)" EXACT [UniProtKB:Q60805] xref: UniProtKB:Q60805 is_a: PR:000010329 ! tyrosine-protein kinase Mer is_a: PR:000029032 ! Mus musculus protein intersection_of: PR:000010329 ! tyrosine-protein kinase Mer intersection_of: RO:0002160 NCBITaxon:10090 ! only in taxon Mus musculus [Term] id: PR:Q60841 name: reelin (mouse) namespace: protein def: "A reelin that is encoded in the genome of mouse." [OMA:Q60841, PRO:DNx] comment: Category=organism-gene. synonym: "mRELN" EXACT PRO-short-label [PRO:DNx] synonym: "reeler protein (mouse)" EXACT [UniProtKB:Q60841] synonym: "Reln" RELATED Gene-based [UniProtKB:Q60841] synonym: "Rl" RELATED Gene-based [UniProtKB:Q60841] xref: UniProtKB:Q60841 is_a: PR:000013879 ! reelin is_a: PR:000029032 ! Mus musculus protein intersection_of: PR:000013879 ! reelin intersection_of: RO:0002160 NCBITaxon:10090 ! only in taxon Mus musculus [Term] id: PR:Q61176 name: arginase-1 (mouse) namespace: protein def: "An arginase-1 that is encoded in the genome of mouse." [OMA:Q61176, PRO:DNx] comment: Category=organism-gene. synonym: "Arg1" RELATED Gene-based [UniProtKB:Q61176] synonym: "liver-type arginase (mouse)" EXACT [UniProtKB:Q61176] synonym: "mARG1" EXACT PRO-short-label [PRO:DNx] synonym: "type I arginase (mouse)" EXACT [UniProtKB:Q61176] xref: UniProtKB:Q61176 is_a: PR:000001844 ! arginase-1 is_a: PR:000029032 ! Mus musculus protein intersection_of: PR:000001844 ! arginase-1 intersection_of: RO:0002160 NCBITaxon:10090 ! only in taxon Mus musculus [Term] id: PR:Q61245 name: collagen alpha-1(XI) chain (mouse) namespace: protein def: "A collagen alpha-1(XI) chain that is encoded in the genome of mouse." [OMA:Q61245, PRO:DNx] comment: Category=organism-gene. synonym: "Col11a1" RELATED Gene-based [UniProtKB:Q61245] synonym: "mCOL11A1" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:Q61245 is_a: PR:000005694 ! collagen alpha-1(XI) chain is_a: PR:000029032 ! Mus musculus protein intersection_of: PR:000005694 ! collagen alpha-1(XI) chain intersection_of: RO:0002160 NCBITaxon:10090 ! only in taxon Mus musculus [Term] id: PR:Q61391 name: neprilysin (mouse) namespace: protein def: "A neprilysin that is encoded in the genome of mouse." [OMA:Q61391, PRO:DNx] comment: Category=organism-gene. synonym: "atriopeptidase (mouse)" EXACT [UniProtKB:Q61391] synonym: "CD10 (mouse)" EXACT [UniProtKB:Q61391] synonym: "enkephalinase (mouse)" EXACT [UniProtKB:Q61391] synonym: "Mme" RELATED Gene-based [UniProtKB:Q61391] synonym: "mMME" EXACT PRO-short-label [PRO:DNx] synonym: "NEP (mouse)" EXACT [UniProtKB:Q61391] synonym: "neutral endopeptidase (mouse)" EXACT [UniProtKB:Q61391] synonym: "neutral endopeptidase 24.11 (mouse)" EXACT [UniProtKB:Q61391] synonym: "SFE (mouse)" EXACT [UniProtKB:Q61391] synonym: "skin fibroblast elastase (mouse)" EXACT [UniProtKB:Q61391] xref: UniProtKB:Q61391 is_a: PR:000001898 ! neprilysin is_a: PR:000029032 ! Mus musculus protein intersection_of: PR:000001898 ! neprilysin intersection_of: RO:0002160 NCBITaxon:10090 ! only in taxon Mus musculus [Term] id: PR:Q61549 name: adhesion G protein-coupled receptor E1 (mouse) namespace: protein def: "An adhesion G protein-coupled receptor E1 that is encoded in the genome of mouse." [OMA:Q61549, PRO:DNx] comment: Category=organism-gene. synonym: "Adgre1" RELATED Gene-based [UniProtKB:Q61549] synonym: "cell surface glycoprotein F4/80 (mouse)" EXACT [UniProtKB:Q61549] synonym: "EGF-like module receptor 1 (mouse)" EXACT [UniProtKB:Q61549] synonym: "EGF-like module-containing mucin-like hormone receptor-like 1 (mouse)" EXACT [UniProtKB:Q61549] synonym: "Emr1" RELATED Gene-based [UniProtKB:Q61549] synonym: "EMR1 hormone receptor (mouse)" EXACT [UniProtKB:Q61549] synonym: "Gpf480" RELATED Gene-based [UniProtKB:Q61549] synonym: "mADGRE1" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:Q61549 is_a: PR:000001813 ! adhesion G protein-coupled receptor E1 is_a: PR:000029032 ! Mus musculus protein intersection_of: PR:000001813 ! adhesion G protein-coupled receptor E1 intersection_of: RO:0002160 NCBITaxon:10090 ! only in taxon Mus musculus [Term] id: PR:Q61575 name: forkhead box protein N1 (mouse) namespace: protein def: "A forkhead box protein N1 that is encoded in the genome of mouse." [OMA:Q61575, PRO:DNx] comment: Category=organism-gene. synonym: "Fkh19" RELATED Gene-based [UniProtKB:Q61575] synonym: "Foxn1" RELATED Gene-based [UniProtKB:Q61575] synonym: "hepatocyte nuclear factor 3 forkhead homolog 11 (mouse)" EXACT [UniProtKB:Q61575] synonym: "HFH-11 (mouse)" EXACT [UniProtKB:Q61575] synonym: "Hfh11" RELATED Gene-based [UniProtKB:Q61575] synonym: "HNF-3/forkhead homolog 11 (mouse)" EXACT [UniProtKB:Q61575] synonym: "mFOXN1" EXACT PRO-short-label [PRO:DNx] synonym: "Whn" RELATED Gene-based [UniProtKB:Q61575] synonym: "winged-helix transcription factor nude (mouse)" EXACT [UniProtKB:Q61575] xref: UniProtKB:Q61575 is_a: PR:000007636 ! forkhead box protein N1 is_a: PR:000029032 ! Mus musculus protein intersection_of: PR:000007636 ! forkhead box protein N1 intersection_of: RO:0002160 NCBITaxon:10090 ! only in taxon Mus musculus [Term] id: PR:Q61616 name: D(1A) dopamine receptor (mouse) namespace: protein def: "A D(1A) dopamine receptor that is encoded in the genome of mouse." [OMA:Q61616, PRO:DNx] comment: Category=organism-gene. synonym: "dopamine D1 receptor (mouse)" EXACT [UniProtKB:Q61616] synonym: "Drd1" RELATED Gene-based [UniProtKB:Q61616] synonym: "Drd1a" RELATED Gene-based [UniProtKB:Q61616] synonym: "Gpcr15" RELATED Gene-based [UniProtKB:Q61616] synonym: "mDRD1" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:Q61616 is_a: PR:000001175 ! D(1A) dopamine receptor is_a: PR:000029032 ! Mus musculus protein intersection_of: PR:000001175 ! D(1A) dopamine receptor intersection_of: RO:0002160 NCBITaxon:10090 ! only in taxon Mus musculus [Term] id: PR:Q61830 name: macrophage mannose receptor 1 (mouse) namespace: protein def: "A macrophage mannose receptor 1 that is encoded in the genome of mouse." [OMA:Q61830, PRO:DNx] comment: Category=organism-gene. synonym: "CD206 (mouse)" EXACT [UniProtKB:Q61830] synonym: "MMR (mouse)" EXACT [UniProtKB:Q61830] synonym: "mMRC1" EXACT PRO-short-label [PRO:DNx] synonym: "Mrc1" RELATED Gene-based [UniProtKB:Q61830] xref: UniProtKB:Q61830 is_a: PR:000002972 ! macrophage mannose receptor 1 is_a: PR:000029032 ! Mus musculus protein intersection_of: PR:000002972 ! macrophage mannose receptor 1 intersection_of: RO:0002160 NCBITaxon:10090 ! only in taxon Mus musculus [Term] id: PR:Q61878 name: bone marrow proteoglycan (mouse) namespace: protein def: "A bone marrow proteoglycan that is encoded in the genome of mouse." [OMA:Q61878, PRO:DNx] comment: Category=organism-gene. synonym: "BMPG (mouse)" EXACT [UniProtKB:Q61878] synonym: "Mbp-1" RELATED Gene-based [UniProtKB:Q61878] synonym: "mPRG2" EXACT PRO-short-label [PRO:DNx] synonym: "Prg2" RELATED Gene-based [UniProtKB:Q61878] synonym: "proteoglycan 2 (mouse)" EXACT [UniProtKB:Q61878] xref: UniProtKB:Q61878 is_a: PR:000013206 ! bone marrow proteoglycan is_a: PR:000029032 ! Mus musculus protein intersection_of: PR:000013206 ! bone marrow proteoglycan intersection_of: RO:0002160 NCBITaxon:10090 ! only in taxon Mus musculus [Term] id: PR:Q61878-1 name: bone marrow proteoglycan isoform 1 (mouse) namespace: protein def: "A bone marrow proteoglycan isoform 1 that is encoded in the genome of mouse." [PRO:CNA] comment: Category=organism-sequence. synonym: "mPRG2/iso:1" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:Q61878-1 is_a: PR:000022003 ! bone marrow proteoglycan isoform 1 is_a: PR:Q61878 ! bone marrow proteoglycan (mouse) intersection_of: PR:000022003 ! bone marrow proteoglycan isoform 1 intersection_of: RO:0002160 NCBITaxon:10090 ! only in taxon Mus musculus [Term] id: PR:Q62009 name: periostin (mouse) namespace: protein def: "A periostin that is encoded in the genome of mouse." [OMA:Q62009, PRO:DNx] comment: Category=organism-gene. synonym: "mPOSTN" EXACT PRO-short-label [PRO:DNx] synonym: "OSF-2 (mouse)" RELATED [UniProtKB:Q62009] synonym: "Osf2" RELATED Gene-based [UniProtKB:Q62009] synonym: "osteoblast-specific factor 2 (mouse)" EXACT [UniProtKB:Q62009] synonym: "PN (mouse)" EXACT [UniProtKB:Q62009] synonym: "Postn" RELATED Gene-based [UniProtKB:Q62009] xref: UniProtKB:Q62009 is_a: PR:000013031 ! periostin is_a: PR:000029032 ! Mus musculus protein intersection_of: PR:000013031 ! periostin intersection_of: RO:0002160 NCBITaxon:10090 ! only in taxon Mus musculus [Term] id: PR:Q62205 name: sodium channel protein type 9 subunit alpha (mouse) namespace: protein def: "A sodium channel protein type 9 subunit alpha that is encoded in the genome of mouse." [OMA:Q62205, PRO:DNx] comment: Category=organism-gene. synonym: "Kiaa4197" RELATED Gene-based [UniProtKB:Q62205] synonym: "mSCN9A" EXACT PRO-short-label [PRO:DNx] synonym: "peripheral sodium channel 1 (mouse)" EXACT [UniProtKB:Q62205] synonym: "PN1 (mouse)" EXACT [UniProtKB:Q62205] synonym: "Scn9a" RELATED Gene-based [UniProtKB:Q62205] synonym: "sodium channel protein type IX subunit alpha (mouse)" EXACT [UniProtKB:Q62205] synonym: "voltage-gated sodium channel subunit alpha Nav1.7 (mouse)" EXACT [UniProtKB:Q62205] xref: UniProtKB:Q62205 is_a: PR:000002104 ! sodium channel protein type 9 subunit alpha is_a: PR:000029032 ! Mus musculus protein intersection_of: PR:000002104 ! sodium channel protein type 9 subunit alpha intersection_of: RO:0002160 NCBITaxon:10090 ! only in taxon Mus musculus [Term] id: PR:Q62226 name: sonic hedgehog protein (mouse) namespace: protein def: "A sonic hedgehog protein that is encoded in the genome of mouse." [OMA:Q62226, PRO:DNx] comment: Category=organism-gene. synonym: "HHG-1 (mouse)" EXACT [UniProtKB:Q62226] synonym: "Hhg1" RELATED Gene-based [UniProtKB:Q62226] synonym: "mSHH" EXACT PRO-short-label [PRO:DNx] synonym: "Shh" RELATED Gene-based [UniProtKB:Q62226] synonym: "SHH (mouse)" EXACT [UniProtKB:Q62226] synonym: "Shh unprocessed N-terminal signaling and C-terminal autoprocessing domains (mouse)" EXACT [UniProtKB:Q62226] synonym: "ShhNC (mouse)" EXACT [UniProtKB:Q62226] xref: UniProtKB:Q62226 is_a: PR:000014841 ! sonic hedgehog protein is_a: PR:000029032 ! Mus musculus protein intersection_of: PR:000014841 ! sonic hedgehog protein intersection_of: RO:0002160 NCBITaxon:10090 ! only in taxon Mus musculus [Term] id: PR:Q62230 name: sialoadhesin (mouse) namespace: protein def: "A sialoadhesin that is encoded in the genome of mouse." [PRO:WCB] comment: Category=organism-gene. synonym: "CD169 (mouse)" EXACT [UniProtKB:Q62230] synonym: "mSIGLEC1" EXACT PRO-short-label [PRO:DNx] synonym: "Sa" RELATED Gene-based [UniProtKB:Q62230] synonym: "SER (mouse)" EXACT [UniProtKB:Q62230] synonym: "sheep erythrocyte receptor (mouse)" EXACT [UniProtKB:Q62230] synonym: "sialic acid-binding Ig-like lectin 1 (mouse)" EXACT [UniProtKB:Q62230] synonym: "siglec-1 (mouse)" EXACT [UniProtKB:Q62230] synonym: "Siglec1" RELATED Gene-based [UniProtKB:Q62230] synonym: "Sn" RELATED Gene-based [UniProtKB:Q62230] xref: UniProtKB:Q62230 is_a: PR:000001931 ! sialoadhesin is_a: PR:000029032 ! Mus musculus protein intersection_of: PR:000001931 ! sialoadhesin intersection_of: RO:0002160 NCBITaxon:10090 ! only in taxon Mus musculus [Term] id: PR:Q62233 name: homeobox protein SIX3 (mouse) namespace: protein def: "A homeobox protein SIX3 that is encoded in the genome of mouse." [OMA:Q62233, PRO:DNx] comment: Category=organism-gene. synonym: "mSIX3" EXACT PRO-short-label [PRO:DNx] synonym: "sine oculis homeobox homolog 3 (mouse)" EXACT [UniProtKB:Q62233] synonym: "Six3" RELATED Gene-based [UniProtKB:Q62233] xref: UniProtKB:Q62233 is_a: PR:000014898 ! homeobox protein SIX3 is_a: PR:000029032 ! Mus musculus protein intersection_of: PR:000014898 ! homeobox protein SIX3 intersection_of: RO:0002160 NCBITaxon:10090 ! only in taxon Mus musculus [Term] id: PR:Q62351 name: transferrin receptor protein 1 (mouse) namespace: protein def: "A transferrin receptor protein 1 that is encoded in the genome of mouse." [OMA:Q62351, PRO:DNx] comment: Category=organism-gene. synonym: "CD71 (mouse)" EXACT [UniProtKB:Q62351] synonym: "mTFRC" EXACT PRO-short-label [PRO:DNx] synonym: "TfR (mouse)" EXACT [UniProtKB:Q62351] synonym: "TfR1 (mouse)" EXACT [UniProtKB:Q62351] synonym: "Tfrc" RELATED Gene-based [UniProtKB:Q62351] synonym: "TR (mouse)" RELATED [UniProtKB:Q62351] synonym: "Trfr" RELATED Gene-based [UniProtKB:Q62351] xref: UniProtKB:Q62351 is_a: PR:000001945 ! transferrin receptor protein 1 is_a: PR:000029032 ! Mus musculus protein intersection_of: PR:000001945 ! transferrin receptor protein 1 intersection_of: RO:0002160 NCBITaxon:10090 ! only in taxon Mus musculus [Term] id: PR:Q62469 name: integrin alpha-2 (mouse) namespace: protein def: "An integrin alpha-2 that is encoded in the genome of mouse." [OMA:Q62469, PRO:DNx] comment: Category=organism-gene. synonym: "CD49 antigen-like family member B (mouse)" EXACT [UniProtKB:Q62469] synonym: "CD49b (mouse)" EXACT [UniProtKB:Q62469] synonym: "collagen receptor (mouse)" EXACT [UniProtKB:Q62469] synonym: "GPIa (mouse)" EXACT [UniProtKB:Q62469] synonym: "Itga2" RELATED Gene-based [UniProtKB:Q62469] synonym: "mITGA2" EXACT PRO-short-label [PRO:DNx] synonym: "platelet membrane glycoprotein Ia (mouse)" EXACT [UniProtKB:Q62469] synonym: "VLA-2 subunit alpha (mouse)" EXACT [UniProtKB:Q62469] xref: UniProtKB:Q62469 is_a: PR:000001008 ! integrin alpha-2 is_a: PR:000029032 ! Mus musculus protein intersection_of: PR:000001008 ! integrin alpha-2 intersection_of: RO:0002160 NCBITaxon:10090 ! only in taxon Mus musculus [Term] id: PR:Q63961 name: endoglin (mouse) namespace: protein def: "An endoglin that is encoded in the genome of mouse." [OMA:Q63961, PRO:DNx] comment: Category=organism-gene. synonym: "CD105 (mouse)" EXACT [UniProtKB:Q63961] synonym: "cell surface MJ7/18 antigen (mouse)" EXACT [UniProtKB:Q63961] synonym: "Edg" RELATED Gene-based [UniProtKB:Q63961] synonym: "Eng" RELATED Gene-based [UniProtKB:Q63961] synonym: "mENG" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:Q63961 is_a: PR:000001345 ! endoglin is_a: PR:000029032 ! Mus musculus protein intersection_of: PR:000001345 ! endoglin intersection_of: RO:0002160 NCBITaxon:10090 ! only in taxon Mus musculus [Term] id: PR:Q63994 name: myeloid cell surface antigen CD33 (mouse) namespace: protein def: "A CD33 molecule that is encoded in the genome of mouse." [PRO:WCB] comment: Category=organism-gene. synonym: "Cd33" RELATED Gene-based [UniProtKB:Q63994] synonym: "CD33 (mouse)" EXACT [UniProtKB:Q63994] synonym: "mCD33" EXACT PRO-short-label [PRO:DNx] synonym: "sialic acid-binding Ig-like lectin 3 (mouse)" EXACT [UniProtKB:Q63994] synonym: "siglec-3 (mouse)" EXACT [UniProtKB:Q63994] synonym: "Siglec3" RELATED Gene-based [UniProtKB:Q63994] xref: UniProtKB:Q63994 is_a: PR:000001892 ! CD33 molecule is_a: PR:000029032 ! Mus musculus protein intersection_of: PR:000001892 ! CD33 molecule intersection_of: RO:0002160 NCBITaxon:10090 ! only in taxon Mus musculus [Term] id: PR:Q64237 name: dopamine beta-hydroxylase (mouse) namespace: protein def: "A dopamine beta-hydroxylase that is encoded in the genome of mouse." [OMA:Q64237, PRO:DNx] comment: Category=organism-gene. synonym: "Dbh" RELATED Gene-based [UniProtKB:Q64237] synonym: "dopamine beta-monooxygenase (mouse)" EXACT [UniProtKB:Q64237] synonym: "mDBH" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:Q64237 is_a: PR:000006294 ! dopamine beta-hydroxylase is_a: PR:000029032 ! Mus musculus protein intersection_of: PR:000006294 ! dopamine beta-hydroxylase intersection_of: RO:0002160 NCBITaxon:10090 ! only in taxon Mus musculus [Term] id: PR:Q64314 name: hematopoietic progenitor cell antigen CD34 (mouse) namespace: protein def: "A CD34 molecule that is encoded in the genome of mouse." [OMA:Q64314, PRO:DNx] comment: Category=organism-gene. synonym: "Cd34" RELATED Gene-based [UniProtKB:Q64314] synonym: "CD34 (mouse)" EXACT [UniProtKB:Q64314] synonym: "mCD34" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:Q64314 is_a: PR:000001003 ! CD34 molecule is_a: PR:000029032 ! Mus musculus protein intersection_of: PR:000001003 ! CD34 molecule intersection_of: RO:0002160 NCBITaxon:10090 ! only in taxon Mus musculus [Term] id: PR:Q64329 name: killer cell lectin-like receptor 3 (mouse) namespace: protein def: "A killer cell lectin-like receptor 3 that is encoded in the genome of mouse." [PRO:DNx, UniProtKB:Q64329] comment: Category=organism-gene. synonym: "5E6 (mouse)" EXACT [UniProtKB:Q64329] synonym: "Klra3" RELATED Gene-based [UniProtKB:Q64329] synonym: "Ly-49c" RELATED Gene-based [UniProtKB:Q64329] synonym: "Ly49C" RELATED Gene-based [UniProtKB:Q64329] synonym: "lymphocyte antigen 49c (mouse)" EXACT [UniProtKB:Q64329] synonym: "mKlra3" EXACT PRO-short-label [PRO:DNx] synonym: "Nk2.1 (mouse)" EXACT [UniProtKB:Q64329] synonym: "T-cell surface glycoprotein Ly-49C (mouse)" EXACT [UniProtKB:Q64329] xref: UniProtKB:Q64329 is_a: PR:000009618 ! killer cell lectin-like receptor 3 is_a: PR:000029032 ! Mus musculus protein intersection_of: PR:000009618 ! killer cell lectin-like receptor 3 intersection_of: RO:0002160 NCBITaxon:10090 ! only in taxon Mus musculus [Term] id: PR:Q67BJ4 name: lactosylceramide 4-alpha-galactosyltransferase (mouse) namespace: protein def: "A lactosylceramide 4-alpha-galactosyltransferase that is encoded in the genome of mouse." [OMA:Q67BJ4, PRO:DNx] comment: Category=organism-gene. synonym: "A4galt" RELATED Gene-based [UniProtKB:Q67BJ4] synonym: "alpha-1,4-galactosyltransferase (mouse)" EXACT [UniProtKB:Q67BJ4] synonym: "alpha-1,4-N-acetylglucosaminyltransferase (mouse)" RELATED [PRO:DNx, UniProtKB:Q67BJ4] synonym: "alpha4Gal-T1 (mouse)" EXACT [UniProtKB:Q67BJ4] synonym: "Gb3 synthase (mouse)" EXACT [UniProtKB:Q67BJ4] synonym: "globotriaosylceramide synthase (mouse)" EXACT [UniProtKB:Q67BJ4] synonym: "mA4GALT" EXACT PRO-short-label [PRO:DNx] synonym: "UDP-galactose:beta-D-galactosyl-beta1-R 4-alpha-D-galactosyltransferase (mouse)" EXACT [UniProtKB:Q67BJ4] xref: UniProtKB:Q67BJ4 is_a: PR:000003516 ! lactosylceramide 4-alpha-galactosyltransferase is_a: PR:000029032 ! Mus musculus protein intersection_of: PR:000003516 ! lactosylceramide 4-alpha-galactosyltransferase intersection_of: RO:0002160 NCBITaxon:10090 ! only in taxon Mus musculus [Term] id: PR:Q6DYE8 name: ectonucleotide pyrophosphatase/phosphodiesterase family member 3 (mouse) namespace: protein def: "An ectonucleotide pyrophosphatase/phosphodiesterase family member 3 that is encoded in the genome of mouse." [OMA:Q6DYE8, PRO:DNx] comment: Category=organism-gene. synonym: "alkaline phosphodiesterase I (mouse)" RELATED [UniProtKB:Q6DYE8] synonym: "CD203c (mouse)" EXACT [UniProtKB:Q6DYE8] synonym: "dinucleoside polyphosphatase (mouse)" EXACT [UniProtKB:Q6DYE8] synonym: "E-NPP 3 (mouse)" EXACT [UniProtKB:Q6DYE8] synonym: "Enpp3" RELATED Gene-based [UniProtKB:Q6DYE8] synonym: "mENPP3" EXACT PRO-short-label [PRO:DNx] synonym: "NPPase (mouse)" RELATED [UniProtKB:Q6DYE8] synonym: "nucleotide diphosphatase (mouse)" RELATED [UniProtKB:Q6DYE8] synonym: "nucleotide pyrophosphatase (mouse)" RELATED [UniProtKB:Q6DYE8] synonym: "PD-Ibeta (mouse)" EXACT [UniProtKB:Q6DYE8] synonym: "phosphodiesterase I beta (mouse)" EXACT [UniProtKB:Q6DYE8] synonym: "phosphodiesterase I/nucleotide pyrophosphatase 3 (mouse)" EXACT [UniProtKB:Q6DYE8] xref: UniProtKB:Q6DYE8 is_a: PR:000001344 ! ectonucleotide pyrophosphatase/phosphodiesterase family member 3 is_a: PR:000029032 ! Mus musculus protein intersection_of: PR:000001344 ! ectonucleotide pyrophosphatase/phosphodiesterase family member 3 intersection_of: RO:0002160 NCBITaxon:10090 ! only in taxon Mus musculus [Term] id: PR:Q6EIG7 name: C-type lectin domain family 6 member A (human) namespace: protein def: "A C-type lectin domain family 6 member A that is encoded in the genome of human." [PRO:WCB, UniProtKB:Q6EIG7] comment: Category=organism-gene. synonym: "C-type lectin superfamily member 10 (human)" EXACT [UniProtKB:Q6EIG7] synonym: "CLEC6A" RELATED Gene-based [UniProtKB:Q6EIG7] synonym: "CLECSF10" RELATED Gene-based [UniProtKB:Q6EIG7] synonym: "DC-associated C-type lectin 2 (human)" EXACT [UniProtKB:Q6EIG7] synonym: "dectin-2 (human)" EXACT [UniProtKB:Q6EIG7] synonym: "DECTIN2" RELATED Gene-based [UniProtKB:Q6EIG7] synonym: "dendritic cell-associated C-type lectin 2 (human)" EXACT [UniProtKB:Q6EIG7] synonym: "hCLEC6A" EXACT PRO-short-label [PRO:DNx] xref: Reactome:R-HSA-1472857 "PR:Q6EIG7 located_in GO:0005886" xref: UniProtKB:Q6EIG7 is_a: PR:000001806 ! C-type lectin domain family 6 member A is_a: PR:000029067 ! Homo sapiens protein intersection_of: PR:000001806 ! C-type lectin domain family 6 member A intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:Q6PZD9 name: CCAAT/enhancer-binding protein epsilon (mouse) namespace: protein def: "A CCAAT/enhancer-binding protein epsilon that is encoded in the genome of mouse." [OMA:Q6PZD9, PRO:DNx] comment: Category=organism-gene. synonym: "C/EBP epsilon (mouse)" EXACT [UniProtKB:Q6PZD9] synonym: "Cebpe" RELATED Gene-based [UniProtKB:Q6PZD9] synonym: "Gm294" RELATED Gene-based [UniProtKB:Q6PZD9] synonym: "mCEBPE" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:Q6PZD9 is_a: PR:000005310 ! CCAAT/enhancer-binding protein epsilon is_a: PR:000029032 ! Mus musculus protein intersection_of: PR:000005310 ! CCAAT/enhancer-binding protein epsilon intersection_of: RO:0002160 NCBITaxon:10090 ! only in taxon Mus musculus [Term] id: PR:Q6QLQ4 name: C-type lectin domain family 7 member A (mouse) namespace: protein def: "A C-type lectin domain family 7 member A that is encoded in the genome of mouse." [OMA:Q6QLQ4, PRO:DNx] comment: Category=organism-gene. synonym: "beta-glucan receptor (mouse)" EXACT [UniProtKB:Q6QLQ4] synonym: "Bgr" RELATED Gene-based [UniProtKB:Q6QLQ4] synonym: "C-type lectin superfamily member 12 (mouse)" EXACT [UniProtKB:Q6QLQ4] synonym: "CD369 (mouse)" EXACT [UniProtKB:Q6QLQ4] synonym: "Clec7a" RELATED Gene-based [UniProtKB:Q6QLQ4] synonym: "Clecsf12" RELATED Gene-based [UniProtKB:Q6QLQ4] synonym: "DC-associated C-type lectin 1 (mouse)" EXACT [UniProtKB:Q6QLQ4] synonym: "dectin-1 (mouse)" EXACT [UniProtKB:Q6QLQ4] synonym: "Dectin1" RELATED Gene-based [UniProtKB:Q6QLQ4] synonym: "dendritic cell-associated C-type lectin 1 (mouse)" EXACT [UniProtKB:Q6QLQ4] synonym: "mCLEC7A" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:Q6QLQ4 is_a: PR:000001807 ! C-type lectin domain family 7 member A is_a: PR:000029032 ! Mus musculus protein intersection_of: PR:000001807 ! C-type lectin domain family 7 member A intersection_of: RO:0002160 NCBITaxon:10090 ! only in taxon Mus musculus [Term] id: PR:Q6R6I7 name: relaxin receptor 1 (mouse) namespace: protein def: "A relaxin receptor 1 that is encoded in the genome of mouse." [OMA:Q6R6I7, PRO:DNx] comment: Category=organism-gene. synonym: "Gm1018" RELATED Gene-based [UniProtKB:Q6R6I7] synonym: "leucine-rich repeat-containing G-protein coupled receptor 7 (mouse)" EXACT [UniProtKB:Q6R6I7] synonym: "Lgr7" RELATED Gene-based [UniProtKB:Q6R6I7] synonym: "mRXFP1" EXACT PRO-short-label [PRO:DNx] synonym: "relaxin family peptide receptor 1 (mouse)" EXACT [UniProtKB:Q6R6I7] synonym: "Rxfp1" RELATED Gene-based [UniProtKB:Q6R6I7] xref: UniProtKB:Q6R6I7 is_a: PR:000001666 ! relaxin receptor 1 is_a: PR:000029032 ! Mus musculus protein intersection_of: PR:000001666 ! relaxin receptor 1 intersection_of: RO:0002160 NCBITaxon:10090 ! only in taxon Mus musculus [Term] id: PR:Q6UVY6 name: DBH-like monooxygenase protein 1 (human) namespace: protein def: "A DBH-like monooxygenase protein 1 that is encoded in the genome of human." [PRO:DNx, UniProtKB:Q6UVY6] comment: Category=organism-gene. synonym: "hMOXD1" EXACT PRO-short-label [PRO:DNx] synonym: "monooxygenase X (human)" EXACT [UniProtKB:Q6UVY6] synonym: "MOX" RELATED Gene-based [UniProtKB:Q6UVY6] synonym: "MOXD1" RELATED Gene-based [UniProtKB:Q6UVY6] synonym: "UNQ2493/PRO5780" RELATED Gene-based [UniProtKB:Q6UVY6] xref: UniProtKB:Q6UVY6 is_a: PR:000010529 ! DBH-like monooxygenase protein 1 is_a: PR:000029067 ! Homo sapiens protein intersection_of: PR:000010529 ! DBH-like monooxygenase protein 1 intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:Q6Y4S4 name: metastasis-suppressor KiSS-1 (mouse) namespace: protein def: "A metastasis-suppressor KiSS-1 that is encoded in the genome of mouse." [OMA:Q6Y4S4, PRO:DNx] comment: Category=organism-gene. synonym: "Kiss1" RELATED Gene-based [UniProtKB:Q6Y4S4] synonym: "kisspeptin-1 (mouse)" EXACT [UniProtKB:Q6Y4S4] synonym: "mKISS1" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:Q6Y4S4 is_a: PR:000009344 ! metastasis-suppressor KiSS-1 is_a: PR:000029032 ! Mus musculus protein intersection_of: PR:000009344 ! metastasis-suppressor KiSS-1 intersection_of: RO:0002160 NCBITaxon:10090 ! only in taxon Mus musculus [Term] id: PR:Q704Y3 name: transient receptor potential cation channel subfamily V member 1 (mouse) namespace: protein def: "A transient receptor potential cation channel TRPV1 that is encoded in the genome of mouse." [OMA:Q704Y3, PRO:DNx] comment: Category=organism-gene. synonym: "mTRPV1" EXACT PRO-short-label [PRO:DNx] synonym: "Osm-9-like TRP channel 1 (mouse)" EXACT [UniProtKB:Q704Y3] synonym: "OTRPC1 (mouse)" EXACT [UniProtKB:Q704Y3] synonym: "Trpv1" RELATED Gene-based [UniProtKB:Q704Y3] synonym: "TrpV1 (mouse)" EXACT [UniProtKB:Q704Y3] synonym: "vanilloid receptor 1 (mouse)" EXACT [UniProtKB:Q704Y3] xref: UniProtKB:Q704Y3 is_a: PR:000001065 ! transient receptor potential cation channel TRPV1 is_a: PR:000029032 ! Mus musculus protein intersection_of: PR:000001065 ! transient receptor potential cation channel TRPV1 intersection_of: RO:0002160 NCBITaxon:10090 ! only in taxon Mus musculus [Term] id: PR:Q86VB7 name: scavenger receptor cysteine-rich type 1 protein M130 (human) namespace: protein def: "A scavenger receptor cysteine-rich type 1 protein M130 that is encoded in the genome of human." [PRO:WCB, UniProtKB:Q86VB7] comment: Category=organism-gene. synonym: "CD163" RELATED Gene-based [UniProtKB:Q86VB7] synonym: "hCD163" EXACT PRO-short-label [PRO:DNx] synonym: "hemoglobin scavenger receptor (human)" EXACT [UniProtKB:Q86VB7] synonym: "M130" RELATED Gene-based [UniProtKB:Q86VB7] xref: UniProtKB:Q86VB7 is_a: PR:000001925 ! scavenger receptor cysteine-rich type 1 protein M130 is_a: PR:000029067 ! Homo sapiens protein intersection_of: PR:000001925 ! scavenger receptor cysteine-rich type 1 protein M130 intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:Q8BJI4 name: POU domain, class 6, transcription factor 2 (mouse) namespace: protein def: "A POU domain, class 6, transcription factor 2 that is encoded in the genome of mouse." [PRO:DNx] comment: Category=organism-gene. synonym: "mPOU6F2" EXACT PRO-short-label [PRO:DNx] synonym: "Pou6f2" RELATED Gene-based [UniProtKB:Q8BJI4] xref: UniProtKB:Q8BJI4 is_a: PR:000013047 ! POU domain, class 6, transcription factor 2 is_a: PR:000029032 ! Mus musculus protein intersection_of: PR:000013047 ! POU domain, class 6, transcription factor 2 intersection_of: RO:0002160 NCBITaxon:10090 ! only in taxon Mus musculus [Term] id: PR:Q8BLE7 name: vesicular glutamate transporter 2 (mouse) namespace: protein def: "A vesicular glutamate transporter 2 that is encoded in the genome of mouse." [OMA:Q8BLE7, PRO:DNx] comment: Category=organism-gene. synonym: "differentiation-associated BNPI (mouse)" EXACT [UniProtKB:Q8BLE7] synonym: "differentiation-associated Na(+)-dependent inorganic phosphate cotransporter (mouse)" EXACT [UniProtKB:Q8BLE7] synonym: "Dnpi" RELATED Gene-based [UniProtKB:Q8BLE7] synonym: "mSLC17A6" EXACT PRO-short-label [PRO:DNx] synonym: "Slc17a6" RELATED Gene-based [UniProtKB:Q8BLE7] synonym: "solute carrier family 17 member 6 (mouse)" EXACT [UniProtKB:Q8BLE7] synonym: "Vglut2" RELATED Gene-based [UniProtKB:Q8BLE7] synonym: "VGluT2 (mouse)" EXACT [UniProtKB:Q8BLE7] xref: UniProtKB:Q8BLE7 is_a: PR:000014962 ! vesicular glutamate transporter 2 is_a: PR:000029032 ! Mus musculus protein intersection_of: PR:000014962 ! vesicular glutamate transporter 2 intersection_of: RO:0002160 NCBITaxon:10090 ! only in taxon Mus musculus [Term] id: PR:Q8C567 name: natural cytotoxicity triggering receptor 1 (mouse) namespace: protein def: "A natural cytotoxicity triggering receptor 1 that is encoded in the genome of mouse." [OMA:Q8C567, PRO:WCB] comment: Category=organism-gene. synonym: "activating receptor 1 (mouse)" EXACT [UniProtKB:Q8C567] synonym: "CD335 (mouse)" EXACT [UniProtKB:Q8C567] synonym: "Ly94" RELATED Gene-based [UniProtKB:Q8C567] synonym: "lymphocyte antigen 94 (mouse)" EXACT [UniProtKB:Q8C567] synonym: "mAR-1" EXACT [UniProtKB:Q8C567] synonym: "mNCR1" EXACT PRO-short-label [PRO:DNx] synonym: "mNKp46" EXACT [UniProtKB:Q8C567] synonym: "natural killer cell p46-related protein (mouse)" EXACT [UniProtKB:Q8C567] synonym: "Ncr1" RELATED Gene-based [UniProtKB:Q8C567] synonym: "NK-p46 (mouse)" EXACT [UniProtKB:Q8C567] synonym: "NKp46 (mouse)" EXACT [UniProtKB:Q8C567] xref: UniProtKB:Q8C567 is_a: PR:000001893 ! natural cytotoxicity triggering receptor 1 is_a: PR:000029032 ! Mus musculus protein intersection_of: PR:000001893 ! natural cytotoxicity triggering receptor 1 intersection_of: RO:0002160 NCBITaxon:10090 ! only in taxon Mus musculus [Term] id: PR:Q8CD54 name: piezo-type mechanosensitive ion channel component 2 (mouse) namespace: protein def: "A piezo-type mechanosensitive ion channel component 2 that is encoded in the genome of mouse." [OMA:Q8CD54, PRO:DNx] comment: Category=organism-gene. synonym: "Fam38b" RELATED Gene-based [UniProtKB:Q8CD54] synonym: "mPIEZO2" EXACT PRO-short-label [PRO:DNx] synonym: "Piezo2" RELATED Gene-based [UniProtKB:Q8CD54] synonym: "protein FAM38B (mouse)" EXACT [UniProtKB:Q8CD54] xref: UniProtKB:Q8CD54 is_a: PR:000029032 ! Mus musculus protein is_a: PR:000032708 ! piezo-type mechanosensitive ion channel component 2 intersection_of: PR:000032708 ! piezo-type mechanosensitive ion channel component 2 intersection_of: RO:0002160 NCBITaxon:10090 ! only in taxon Mus musculus [Term] id: PR:Q8CG65 name: SCO-spondin (mouse) namespace: protein def: "A SCO-spondin that is encoded in the genome of mouse." [PRO:DNx] comment: Category=organism-gene. synonym: "mSSPO" EXACT PRO-short-label [PRO:DNx] synonym: "Sspo" RELATED Gene-based [UniProtKB:Q8CG65] xref: UniProtKB:Q8CG65 is_a: PR:000015658 ! SCO-spondin is_a: PR:000029032 ! Mus musculus protein intersection_of: PR:000015658 ! SCO-spondin intersection_of: RO:0002160 NCBITaxon:10090 ! only in taxon Mus musculus [Term] id: PR:Q8CJ91 name: CD209 antigen-like protein B (mouse) namespace: protein def: "A CD209 molecule-like protein B that is encoded in the genome of mouse." [PRO:DNx, UniProtKB:Q8CJ91] comment: Category=organism-gene. synonym: "CD209 (mouse)" BROAD [UniProtKB:Q8CJ91] synonym: "Cd209b" RELATED Gene-based [UniProtKB:Q8CJ91] synonym: "DC-SIGN-related protein 1 (mouse)" EXACT [UniProtKB:Q8CJ91] synonym: "DC-SIGNR1 (mouse)" EXACT [UniProtKB:Q8CJ91] synonym: "mCd209b" EXACT PRO-short-label [PRO:DNx] synonym: "OtB7 (mouse)" EXACT [UniProtKB:Q8CJ91] xref: UniProtKB:Q8CJ91 is_a: PR:000006172 ! CD209 molecule-like protein B is_a: PR:000029032 ! Mus musculus protein intersection_of: PR:000006172 ! CD209 molecule-like protein B intersection_of: RO:0002160 NCBITaxon:10090 ! only in taxon Mus musculus [Term] id: PR:Q8NER1 name: transient receptor potential cation channel subfamily V member 1 (human) namespace: protein def: "A transient receptor potential cation channel TRPV1 that is encoded in the genome of human." [PRO:CNA, UniProtKB:Q8NER1] comment: Category=organism-gene. synonym: "capsaicin receptor (human)" EXACT [UniProtKB:Q8NER1] synonym: "hTRPV1" EXACT PRO-short-label [PRO:DNx] synonym: "Osm-9-like TRP channel 1 (human)" EXACT [UniProtKB:Q8NER1] synonym: "OTRPC1 (human)" EXACT [UniProtKB:Q8NER1] synonym: "TRPV1" RELATED Gene-based [UniProtKB:Q8NER1] synonym: "TrpV1 (human)" EXACT [UniProtKB:Q8NER1] synonym: "vanilloid receptor 1 (human)" EXACT [UniProtKB:Q8NER1] synonym: "VR1" RELATED Gene-based [UniProtKB:Q8NER1] xref: DTO:01100333 xref: Reactome:R-HSA-2671938 "PR:Q8NER1 located_in GO:0005886" xref: UniProtKB:Q8NER1 is_a: PR:000001065 ! transient receptor potential cation channel TRPV1 is_a: PR:000029067 ! Homo sapiens protein intersection_of: PR:000001065 ! transient receptor potential cation channel TRPV1 intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:Q8NFU0 name: bestrophin-4 (human) namespace: protein def: "A bestrophin-4 that is encoded in the genome of human." [PRO:DNx, UniProtKB:Q8NFU0] comment: Category=organism-gene. synonym: "BEST4" RELATED Gene-based [UniProtKB:Q8NFU0] synonym: "hBEST4" EXACT PRO-short-label [PRO:DNx] synonym: "vitelliform macular dystrophy 2-like protein 2 (human)" EXACT [UniProtKB:Q8NFU0] synonym: "VMD2L2" RELATED Gene-based [UniProtKB:Q8NFU0] xref: DTO:01100033 xref: Reactome:R-HSA-2744358 "PR:Q8NFU0 located_in GO:0005886" xref: UniProtKB:Q8NFU0 is_a: PR:000004724 ! bestrophin-4 is_a: PR:000029067 ! Homo sapiens protein intersection_of: PR:000004724 ! bestrophin-4 intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:Q8R2Q8 name: bone marrow stromal antigen 2 (mouse) namespace: protein def: "A bone marrow stromal antigen 2 that is encoded in the genome of mouse." [OMA:Q8R2Q8, PRO:DNx] comment: Category=organism-gene. synonym: "BST-2 (mouse)" EXACT [UniProtKB:Q8R2Q8] synonym: "Bst2" RELATED Gene-based [UniProtKB:Q8R2Q8] synonym: "CD317 (mouse)" EXACT [UniProtKB:Q8R2Q8] synonym: "HM1.24 antigen (mouse)" EXACT [UniProtKB:Q8R2Q8] synonym: "mBST2" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:Q8R2Q8 is_a: PR:000001326 ! bone marrow stromal antigen 2 is_a: PR:000029032 ! Mus musculus protein intersection_of: PR:000001326 ! bone marrow stromal antigen 2 intersection_of: RO:0002160 NCBITaxon:10090 ! only in taxon Mus musculus [Term] id: PR:Q8R4G0 name: netrin-G1 (mouse) namespace: protein def: "A netrin-G1 that is encoded in the genome of mouse." [OMA:Q8R4G0, PRO:DNx] comment: Category=organism-gene. synonym: "Kiaa0976" RELATED Gene-based [UniProtKB:Q8R4G0] synonym: "laminet-1 (mouse)" EXACT [UniProtKB:Q8R4G0] synonym: "Lmnt1" RELATED Gene-based [UniProtKB:Q8R4G0] synonym: "mNTNG1" EXACT PRO-short-label [PRO:DNx] synonym: "Ntng1" RELATED Gene-based [UniProtKB:Q8R4G0] xref: UniProtKB:Q8R4G0 is_a: PR:000011467 ! netrin-G1 is_a: PR:000029032 ! Mus musculus protein intersection_of: PR:000011467 ! netrin-G1 intersection_of: RO:0002160 NCBITaxon:10090 ! only in taxon Mus musculus [Term] id: PR:Q8R4I7 name: neuropilin and tolloid-like protein 1 (mouse) namespace: protein def: "A neuropilin and tolloid-like protein 1 that is encoded in the genome of mouse." [OMA:Q8R4I7, PRO:DNx] comment: Category=organism-gene. synonym: "brain-specific transmembrane protein containing 2 CUB and 1 LDL-receptor class A domains protein 1 (mouse)" EXACT [UniProtKB:Q8R4I7] synonym: "Btcl1" RELATED Gene-based [UniProtKB:Q8R4I7] synonym: "mNETO1" EXACT PRO-short-label [PRO:DNx] synonym: "Neto1" RELATED Gene-based [UniProtKB:Q8R4I7] xref: UniProtKB:Q8R4I7 is_a: PR:000011143 ! neuropilin and tolloid-like protein 1 is_a: PR:000029032 ! Mus musculus protein intersection_of: PR:000011143 ! neuropilin and tolloid-like protein 1 intersection_of: RO:0002160 NCBITaxon:10090 ! only in taxon Mus musculus [Term] id: PR:Q8TDF5 name: neuropilin and tolloid-like protein 1 (human) namespace: protein def: "A neuropilin and tolloid-like protein 1 that is encoded in the genome of human." [PRO:DNx, UniProtKB:Q8TDF5] comment: Category=organism-gene. synonym: "brain-specific transmembrane protein containing 2 CUB and 1 LDL-receptor class A domains protein 1 (human)" EXACT [UniProtKB:Q8TDF5] synonym: "BTCL1" RELATED Gene-based [UniProtKB:Q8TDF5] synonym: "hNETO1" EXACT PRO-short-label [PRO:DNx] synonym: "NETO1" RELATED Gene-based [UniProtKB:Q8TDF5] xref: UniProtKB:Q8TDF5 is_a: PR:000011143 ! neuropilin and tolloid-like protein 1 is_a: PR:000029067 ! Homo sapiens protein intersection_of: PR:000011143 ! neuropilin and tolloid-like protein 1 intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:Q8VBX4 name: C-type lectin domain family 4 member K (mouse) namespace: protein def: "A C-type lectin domain family 4 member K that is encoded in the genome of mouse." [OMA:Q8VBX4, PRO:DNx] comment: Category=organism-gene. synonym: "Cd207" RELATED Gene-based [UniProtKB:Q8VBX4] synonym: "CD207 (mouse)" EXACT [UniProtKB:Q8VBX4] synonym: "Clec4k" RELATED Gene-based [UniProtKB:Q8VBX4] synonym: "langerin (mouse)" EXACT [UniProtKB:Q8VBX4] synonym: "mCD207" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:Q8VBX4 is_a: PR:000001293 ! C-type lectin domain family 4 member K is_a: PR:000029032 ! Mus musculus protein intersection_of: PR:000001293 ! C-type lectin domain family 4 member K intersection_of: RO:0002160 NCBITaxon:10090 ! only in taxon Mus musculus [Term] id: PR:Q8VCC9 name: spondin-1 (mouse) namespace: protein def: "A spondin-1 that is encoded in the genome of mouse." [OMA:Q8VCC9, PRO:DNx] comment: Category=organism-gene. synonym: "F-spondin (mouse)" EXACT [UniProtKB:Q8VCC9] synonym: "mSPON1" EXACT PRO-short-label [PRO:DNx] synonym: "Spon1" RELATED Gene-based [UniProtKB:Q8VCC9] xref: UniProtKB:Q8VCC9 is_a: PR:000015557 ! spondin-1 is_a: PR:000029032 ! Mus musculus protein intersection_of: PR:000015557 ! spondin-1 intersection_of: RO:0002160 NCBITaxon:10090 ! only in taxon Mus musculus [Term] id: PR:Q8WTT0 name: C-type lectin domain family 4 member C (human) namespace: protein def: "A C-type lectin domain family 4 member C that is encoded in the genome of human." [PRO:WCB, UniProtKB:Q8WTT0] comment: Category=organism-gene. synonym: "BDCA-2 (human)" EXACT [UniProtKB:Q8WTT0] synonym: "BDCA2" RELATED Gene-based [UniProtKB:Q8WTT0] synonym: "blood dendritic cell antigen 2 (human)" EXACT [UniProtKB:Q8WTT0] synonym: "C-type lectin superfamily member 7 (human)" EXACT [UniProtKB:Q8WTT0] synonym: "CD303 (human)" EXACT [UniProtKB:Q8WTT0] synonym: "CLEC4C" RELATED Gene-based [UniProtKB:Q8WTT0] synonym: "CLECSF11" RELATED Gene-based [UniProtKB:Q8WTT0] synonym: "CLECSF7" RELATED Gene-based [UniProtKB:Q8WTT0] synonym: "dendritic lectin (human)" EXACT [UniProtKB:Q8WTT0] synonym: "DLEC" RELATED Gene-based [UniProtKB:Q8WTT0] synonym: "hCLEC4C" EXACT PRO-short-label [PRO:DNx] synonym: "HECL" RELATED Gene-based [UniProtKB:Q8WTT0] synonym: "UNQ9361/PRO34150" RELATED Gene-based [UniProtKB:Q8WTT0] xref: Reactome:R-HSA-2130705 "PR:Q8WTT0 located_in GO:0005886" xref: Reactome:R-HSA-6800186 "PR:Q8WTT0 located_in GO:0070821" xref: Reactome:R-HSA-6800915 "PR:Q8WTT0 located_in GO:0101003" xref: Reactome:R-HSA-6801022 "PR:Q8WTT0 located_in GO:0030667" xref: UniProtKB:Q8WTT0 is_a: PR:000001292 ! C-type lectin domain family 4 member C is_a: PR:000029067 ! Homo sapiens protein intersection_of: PR:000001292 ! C-type lectin domain family 4 member C intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:Q920G3 name: sialic acid-binding Ig-like lectin 5 (mouse) namespace: protein def: "A sialic acid-binding Ig-like lectin 5 that is encoded in the genome of mouse." [PRO:WCB] comment: Category=organism-gene. synonym: "CD170 (mouse)" EXACT [UniProtKB:Q920G3] synonym: "mSiglec-F" EXACT [UniProtKB:Q920G3] synonym: "mSIGLEC5" EXACT PRO-short-label [PRO:DNx] synonym: "sialic acid-binding Ig-like lectin F (mouse)" EXACT [UniProtKB:Q920G3] synonym: "siglec-5 (mouse)" RELATED [UniProtKB:Q920G3] synonym: "siglec-F (mouse)" EXACT [UniProtKB:Q920G3] synonym: "Siglec5" RELATED Gene-based [UniProtKB:Q920G3] synonym: "Siglecf" RELATED Gene-based [UniProtKB:Q920G3] xref: UniProtKB:Q920G3 is_a: PR:000001927 ! sialic acid-binding Ig-like lectin 5 is_a: PR:000029032 ! Mus musculus protein intersection_of: PR:000001927 ! sialic acid-binding Ig-like lectin 5 intersection_of: RO:0002160 NCBITaxon:10090 ! only in taxon Mus musculus [Term] id: PR:Q96E93 name: killer cell lectin-like receptor subfamily G member 1 (human) namespace: protein def: "A killer cell lectin-like receptor subfamily G member 1 that is encoded in the genome of human." [PRO:DNx, UniProtKB:Q96E93] comment: Category=organism-gene. synonym: "C-type lectin domain family 15 member A (human)" EXACT [UniProtKB:Q96E93] synonym: "CLEC15A" RELATED Gene-based [UniProtKB:Q96E93] synonym: "hKLRG1" EXACT PRO-short-label [PRO:DNx] synonym: "ITIM-containing receptor MAFA-L (human)" EXACT [UniProtKB:Q96E93] synonym: "KLRG1" RELATED Gene-based [UniProtKB:Q96E93] synonym: "MAFA" RELATED Gene-based [UniProtKB:Q96E93] synonym: "MAFA-like receptor (human)" EXACT [UniProtKB:Q96E93] synonym: "MAFAL" RELATED Gene-based [UniProtKB:Q96E93] synonym: "mast cell function-associated antigen (human)" EXACT [UniProtKB:Q96E93] xref: Reactome:R-HSA-198006 "PR:Q96E93 located_in GO:0005886" xref: UniProtKB:Q96E93 is_a: PR:000009426 ! killer cell lectin-like receptor subfamily G member 1 is_a: PR:000029067 ! Homo sapiens protein intersection_of: PR:000009426 ! killer cell lectin-like receptor subfamily G member 1 intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:Q99259 name: glutamate decarboxylase 1 (human) namespace: protein def: "A glutamate decarboxylase 1 that is encoded in the genome of human." [PRO:DNx, UniProtKB:Q99259] comment: Category=organism-gene. synonym: "67 kDa glutamic acid decarboxylase (human)" EXACT [UniProtKB:Q99259] synonym: "GAD" RELATED Gene-based [UniProtKB:Q99259] synonym: "GAD-67 (human)" EXACT [UniProtKB:Q99259] synonym: "GAD1" RELATED Gene-based [UniProtKB:Q99259] synonym: "GAD67" RELATED Gene-based [UniProtKB:Q99259] synonym: "glutamate decarboxylase 67 kDa isoform (human)" EXACT [UniProtKB:Q99259] synonym: "hGAD1" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:Q99259 is_a: PR:000007785 ! glutamate decarboxylase 1 is_a: PR:000029067 ! Homo sapiens protein intersection_of: PR:000007785 ! glutamate decarboxylase 1 intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:Q99JA0-1 name: calcitonin gene-related peptide 1 (mouse) namespace: protein def: "A calcitonin gene-related peptide 1 that is encoded in the genome of mouse." [PMID:11761712, PRO:HJD] comment: Category=organism-sequence. synonym: "mCALCA/iso:CGRP1" EXACT PRO-short-label [PRO:DAN] xref: UniProtKB:Q99JA0-1 is_a: PR:000027223 ! CALCA gene translation product (mouse) is_a: PR:000027226 ! calcitonin gene-related peptide 1 intersection_of: PR:000027226 ! calcitonin gene-related peptide 1 intersection_of: RO:0002160 NCBITaxon:10090 ! only in taxon Mus musculus [Term] id: PR:Q99JB6 name: forkhead box protein P3 (mouse) namespace: protein def: "A forkhead box protein P3 that is encoded in the genome of mouse." [OMA:Q99JB6, PRO:DNx] comment: Category=organism-gene. synonym: "Foxp3" RELATED Gene-based [UniProtKB:Q99JB6] synonym: "mFOXP3" EXACT PRO-short-label [PRO:DNx] synonym: "scurfin (mouse)" EXACT [UniProtKB:Q99JB6] xref: UniProtKB:Q99JB6 is_a: PR:000001350 ! forkhead box protein P3 is_a: PR:000029032 ! Mus musculus protein intersection_of: PR:000001350 ! forkhead box protein P3 intersection_of: RO:0002160 NCBITaxon:10090 ! only in taxon Mus musculus [Term] id: PR:Q99NH8 name: triggering receptor expressed on myeloid cells 2 (mouse) namespace: protein def: "A triggering receptor expressed on myeloid cells 2 that is encoded in the genome of mouse." [OMA:Q99NH8, PRO:DNx] comment: Category=organism-gene. synonym: "mTREM2" EXACT PRO-short-label [PRO:DNx] synonym: "TREM-2 (mouse)" EXACT [UniProtKB:Q99NH8] synonym: "Trem2" RELATED Gene-based [UniProtKB:Q99NH8] synonym: "Trem2a" RELATED Gene-based [UniProtKB:Q99NH8] synonym: "Trem2b" RELATED Gene-based [UniProtKB:Q99NH8] synonym: "Trem2c" RELATED Gene-based [UniProtKB:Q99NH8] synonym: "triggering receptor expressed on monocytes 2 (mouse)" EXACT [UniProtKB:Q99NH8] xref: UniProtKB:Q99NH8 is_a: PR:000016626 ! triggering receptor expressed on myeloid cells 2 is_a: PR:000029032 ! Mus musculus protein intersection_of: PR:000016626 ! triggering receptor expressed on myeloid cells 2 intersection_of: RO:0002160 NCBITaxon:10090 ! only in taxon Mus musculus [Term] id: PR:Q99PV8 name: B-cell lymphoma/leukemia 11B (mouse) namespace: protein def: "A B-cell lymphoma/leukemia 11B that is encoded in the genome of mouse." [OMA:Q99PV8, PRO:DNx] comment: Category=organism-gene. synonym: "B-cell CLL/lymphoma 11B (mouse)" EXACT [UniProtKB:Q99PV8] synonym: "BCL-11B (mouse)" EXACT [UniProtKB:Q99PV8] synonym: "Bcl11b" RELATED Gene-based [UniProtKB:Q99PV8] synonym: "COUP-TF-interacting protein 2 (mouse)" EXACT [UniProtKB:Q99PV8] synonym: "Ctip2" RELATED Gene-based [UniProtKB:Q99PV8] synonym: "mBCL11B" EXACT PRO-short-label [PRO:DNx] synonym: "mRit1" EXACT [UniProtKB:Q99PV8] synonym: "radiation-induced tumor suppressor gene 1 protein (mouse)" EXACT [UniProtKB:Q99PV8] synonym: "Rit1" RELATED Gene-based [UniProtKB:Q99PV8] xref: UniProtKB:Q99PV8 is_a: PR:000004691 ! B-cell lymphoma/leukemia 11B is_a: PR:000029032 ! Mus musculus protein intersection_of: PR:000004691 ! B-cell lymphoma/leukemia 11B intersection_of: RO:0002160 NCBITaxon:10090 ! only in taxon Mus musculus [Term] id: PR:Q9BXN2 name: C-type lectin domain family 7 member A (human) namespace: protein def: "A C-type lectin domain family 7 member A that is encoded in the genome of human." [PRO:WCB, UniProtKB:Q9BXN2] comment: Category=organism-gene. synonym: "beta-glucan receptor (human)" EXACT [UniProtKB:Q9BXN2] synonym: "BGR" RELATED Gene-based [UniProtKB:Q9BXN2] synonym: "C-type lectin superfamily member 12 (human)" EXACT [UniProtKB:Q9BXN2] synonym: "CD369 (human)" EXACT [UniProtKB:Q9BXN2] synonym: "CLEC7A" RELATED Gene-based [UniProtKB:Q9BXN2] synonym: "CLECSF12" RELATED Gene-based [UniProtKB:Q9BXN2] synonym: "DC-associated C-type lectin 1 (human)" EXACT [UniProtKB:Q9BXN2] synonym: "dectin-1 (human)" EXACT [UniProtKB:Q9BXN2] synonym: "DECTIN1" RELATED Gene-based [UniProtKB:Q9BXN2] synonym: "dendritic cell-associated C-type lectin 1 (human)" EXACT [UniProtKB:Q9BXN2] synonym: "hCLEC7A" EXACT PRO-short-label [PRO:DNx] synonym: "UNQ539/PRO1082" RELATED Gene-based [UniProtKB:Q9BXN2] xref: Reactome:R-HSA-2130683 "PR:Q9BXN2 located_in GO:0005886" xref: UniProtKB:Q9BXN2 is_a: PR:000001807 ! C-type lectin domain family 7 member A is_a: PR:000029067 ! Homo sapiens protein intersection_of: PR:000001807 ! C-type lectin domain family 7 member A intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:Q9BZS1 name: forkhead box protein P3 (human) namespace: protein def: "A forkhead box protein P3 that is encoded in the genome of human." [PRO:CNA, UniProtKB:Q9BZS1] comment: Category=organism-gene. synonym: "FOXP3" RELATED Gene-based [UniProtKB:Q9BZS1] synonym: "hFOXP3" EXACT PRO-short-label [PRO:DNx] synonym: "IPEX" RELATED Gene-based [UniProtKB:Q9BZS1] synonym: "JM2" RELATED Gene-based [UniProtKB:Q9BZS1] synonym: "scurfin (human)" EXACT [UniProtKB:Q9BZS1] xref: Reactome:R-HSA-8865539 "PR:Q9BZS1 located_in GO:0005654" xref: UniProtKB:Q9BZS1 is_a: PR:000001350 ! forkhead box protein P3 is_a: PR:000029067 ! Homo sapiens protein intersection_of: PR:000001350 ! forkhead box protein P3 intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:Q9BZW8 name: natural killer cell receptor 2B4 (human) namespace: protein def: "A natural killer cell receptor 2B4 that is encoded in the genome of human." [PRO:WCB, UniProtKB:Q9BZW8] comment: Category=organism-gene. synonym: "2B4" RELATED Gene-based [UniProtKB:Q9BZW8] synonym: "CD244" RELATED Gene-based [UniProtKB:Q9BZW8] synonym: "h2B4 (human)" EXACT [UniProtKB:Q9BZW8] synonym: "hCD244" EXACT PRO-short-label [PRO:DNx] synonym: "NAIL (human)" EXACT [UniProtKB:Q9BZW8] synonym: "NK cell activation-inducing ligand (human)" EXACT [UniProtKB:Q9BZW8] synonym: "NK cell type I receptor protein 2B4 (human)" EXACT [UniProtKB:Q9BZW8] synonym: "NKR2B4 (human)" EXACT [UniProtKB:Q9BZW8] synonym: "signaling lymphocytic activation molecule 4 (human)" EXACT [UniProtKB:Q9BZW8] synonym: "SLAM family member 4 (human)" EXACT [UniProtKB:Q9BZW8] synonym: "SLAMF4 (human)" EXACT [UniProtKB:Q9BZW8] xref: UniProtKB:Q9BZW8 is_a: PR:000001896 ! natural killer cell receptor 2B4 is_a: PR:000029067 ! Homo sapiens protein intersection_of: PR:000001896 ! natural killer cell receptor 2B4 intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:Q9BZZ2 name: sialoadhesin (human) namespace: protein def: "A sialoadhesin that is encoded in the genome of human." [PRO:WCB, UniProtKB:Q9BZZ2] comment: Category=organism-gene. synonym: "CD169 (human)" EXACT [UniProtKB:Q9BZZ2] synonym: "hSIGLEC1" EXACT PRO-short-label [PRO:DNx] synonym: "sialic acid-binding Ig-like lectin 1 (human)" EXACT [UniProtKB:Q9BZZ2] synonym: "siglec-1 (human)" EXACT [UniProtKB:Q9BZZ2] synonym: "SIGLEC1" RELATED Gene-based [UniProtKB:Q9BZZ2] synonym: "SN" RELATED Gene-based [UniProtKB:Q9BZZ2] xref: UniProtKB:Q9BZZ2 is_a: PR:000001931 ! sialoadhesin is_a: PR:000029067 ! Homo sapiens protein intersection_of: PR:000001931 ! sialoadhesin intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:Q9C0K0 name: B-cell lymphoma/leukemia 11B (human) namespace: protein def: "A B-cell lymphoma/leukemia 11B that is encoded in the genome of human." [PRO:DNx, UniProtKB:Q9C0K0] comment: Category=organism-gene. synonym: "B-cell CLL/lymphoma 11B (human)" EXACT [UniProtKB:Q9C0K0] synonym: "BCL-11B (human)" EXACT [UniProtKB:Q9C0K0] synonym: "BCL11B" RELATED Gene-based [UniProtKB:Q9C0K0] synonym: "COUP-TF-interacting protein 2 (human)" EXACT [UniProtKB:Q9C0K0] synonym: "CTIP2" RELATED Gene-based [UniProtKB:Q9C0K0] synonym: "hBCL11B" EXACT PRO-short-label [PRO:DNx] synonym: "hRit1" EXACT [UniProtKB:Q9C0K0] synonym: "radiation-induced tumor suppressor gene 1 protein (human)" EXACT [UniProtKB:Q9C0K0] synonym: "RIT1" RELATED Gene-based [UniProtKB:Q9C0K0] xref: Reactome:R-HSA-9933971 "PR:Q9C0K0 located_in GO:0005654" xref: UniProtKB:Q9C0K0 is_a: PR:000004691 ! B-cell lymphoma/leukemia 11B is_a: PR:000029067 ! Homo sapiens protein intersection_of: PR:000004691 ! B-cell lymphoma/leukemia 11B intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:Q9CW73 name: galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1 (mouse) namespace: protein def: "A galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1 that is encoded in the genome of mouse." [OMA:Q9CW73, PRO:DNx] comment: Category=organism-gene. synonym: "B3gat1" RELATED Gene-based [UniProtKB:Q9CW73] synonym: "beta-1,3-glucuronyltransferase 1 (mouse)" EXACT [UniProtKB:Q9CW73] synonym: "GlcAT-P (mouse)" EXACT [UniProtKB:Q9CW73] synonym: "GlcUAT-P (mouse)" EXACT [UniProtKB:Q9CW73] synonym: "glucuronosyltransferase P (mouse)" EXACT [UniProtKB:Q9CW73] synonym: "mB3GAT1" EXACT PRO-short-label [PRO:DNx] synonym: "UDP-GlcUA:glycoprotein beta-1,3-glucuronyltransferase (mouse)" EXACT [UniProtKB:Q9CW73] xref: UniProtKB:Q9CW73 is_a: PR:000001440 ! galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1 is_a: PR:000029032 ! Mus musculus protein intersection_of: PR:000001440 ! galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1 intersection_of: RO:0002160 NCBITaxon:10090 ! only in taxon Mus musculus [Term] id: PR:Q9CXI3 name: DBH-like monooxygenase protein 1 (mouse) namespace: protein def: "A DBH-like monooxygenase protein 1 that is encoded in the genome of mouse." [OMA:Q9CXI3, PRO:DNx] comment: Category=organism-gene. synonym: "DBH-related protein (mouse)" EXACT [UniProtKB:Q9CXI3] synonym: "Dbhr" RELATED Gene-based [UniProtKB:Q9CXI3] synonym: "mMOXD1" EXACT PRO-short-label [PRO:DNx] synonym: "monooxygenase X (mouse)" EXACT [UniProtKB:Q9CXI3] synonym: "Mox" RELATED Gene-based [UniProtKB:Q9CXI3] synonym: "Moxd1" RELATED Gene-based [UniProtKB:Q9CXI3] xref: UniProtKB:Q9CXI3 is_a: PR:000010529 ! DBH-like monooxygenase protein 1 is_a: PR:000029032 ! Mus musculus protein intersection_of: PR:000010529 ! DBH-like monooxygenase protein 1 intersection_of: RO:0002160 NCBITaxon:10090 ! only in taxon Mus musculus [Term] id: PR:Q9CXM0 name: chondrolectin (mouse) namespace: protein def: "A chondrolectin that is encoded in the genome of mouse." [OMA:Q9CXM0, PRO:DNx] comment: Category=organism-gene. synonym: "Chodl" RELATED Gene-based [UniProtKB:Q9CXM0] synonym: "mCHODL" EXACT PRO-short-label [PRO:DNx] synonym: "transmembrane protein MT75 (mouse)" EXACT [UniProtKB:Q9CXM0] xref: UniProtKB:Q9CXM0 is_a: PR:000005444 ! chondrolectin is_a: PR:000029032 ! Mus musculus protein intersection_of: PR:000005444 ! chondrolectin intersection_of: RO:0002160 NCBITaxon:10090 ! only in taxon Mus musculus [Term] id: PR:Q9D387 name: lysosome-associated membrane glycoprotein 5 (mouse) namespace: protein def: "A lysosome-associated membrane glycoprotein 5 that is encoded in the genome of mouse." [OMA:Q9D387, PRO:DNx] comment: Category=organism-gene. synonym: "BAD-LAMP (mouse)" EXACT [UniProtKB:Q9D387] synonym: "brain and dendritic cell-associated LAMP (mouse)" EXACT [UniProtKB:Q9D387] synonym: "brain-associated LAMP-like protein (mouse)" EXACT [UniProtKB:Q9D387] synonym: "LAMP-5 (mouse)" EXACT [UniProtKB:Q9D387] synonym: "Lamp5" RELATED Gene-based [UniProtKB:Q9D387] synonym: "lysosome-associated membrane protein 5 (mouse)" EXACT [UniProtKB:Q9D387] synonym: "mLAMP5" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:Q9D387 is_a: PR:000029032 ! Mus musculus protein is_a: PR:000032148 ! lysosome-associated membrane glycoprotein 5 intersection_of: PR:000032148 ! lysosome-associated membrane glycoprotein 5 intersection_of: RO:0002160 NCBITaxon:10090 ! only in taxon Mus musculus [Term] id: PR:Q9ER75 name: iroquois-class homeodomain protein IRX-6 (mouse) namespace: protein def: "An iroquois-class homeodomain protein IRX-6 that is encoded in the genome of mouse." [OMA:Q9ER75, PRO:DNx] comment: Category=organism-gene. synonym: "homeodomain protein IRXB3 (mouse)" EXACT [UniProtKB:Q9ER75] synonym: "iroquois homeobox protein 6 (mouse)" EXACT [UniProtKB:Q9ER75] synonym: "Irx6" RELATED Gene-based [UniProtKB:Q9ER75] synonym: "Irxb3" RELATED Gene-based [UniProtKB:Q9ER75] synonym: "mIRX6" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:Q9ER75 is_a: PR:000029032 ! Mus musculus protein is_a: PR:000029562 ! iroquois-class homeodomain protein IRX-6 intersection_of: PR:000029562 ! iroquois-class homeodomain protein IRX-6 intersection_of: RO:0002160 NCBITaxon:10090 ! only in taxon Mus musculus [Term] id: PR:Q9H334 name: forkhead box protein P1 (human) namespace: protein def: "A forkhead box protein P1 that is encoded in the genome of human." [PRO:DNx, UniProtKB:Q9H334] comment: Category=organism-gene. synonym: "FOXP1" RELATED Gene-based [UniProtKB:Q9H334] synonym: "hFOXP1" EXACT PRO-short-label [PRO:DNx] synonym: "HSPC215" RELATED Gene-based [UniProtKB:Q9H334] synonym: "Mac-1-regulated forkhead (human)" EXACT [UniProtKB:Q9H334] synonym: "MFH (human)" EXACT [UniProtKB:Q9H334] xref: UniProtKB:Q9H334 is_a: PR:000007643 ! forkhead box protein P1 is_a: PR:000029067 ! Homo sapiens protein intersection_of: PR:000007643 ! forkhead box protein P1 intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:Q9H5I5 name: piezo-type mechanosensitive ion channel component 2 (human) namespace: protein def: "A piezo-type mechanosensitive ion channel component 2 that is encoded in the genome of human." [PRO:DNx, UniProtKB:Q9H5I5] comment: Category=organism-gene. synonym: "C18orf30" RELATED Gene-based [UniProtKB:Q9H5I5] synonym: "C18orf58" RELATED Gene-based [UniProtKB:Q9H5I5] synonym: "FAM38B" RELATED Gene-based [UniProtKB:Q9H5I5] synonym: "hPIEZO2" EXACT PRO-short-label [PRO:DNx] synonym: "PIEZO2" RELATED Gene-based [UniProtKB:Q9H5I5] synonym: "protein FAM38B (human)" EXACT [UniProtKB:Q9H5I5] xref: DTO:01100275 xref: UniProtKB:Q9H5I5 is_a: PR:000029067 ! Homo sapiens protein is_a: PR:000032708 ! piezo-type mechanosensitive ion channel component 2 intersection_of: PR:000032708 ! piezo-type mechanosensitive ion channel component 2 intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:Q9H9P2 name: chondrolectin (human) namespace: protein def: "A chondrolectin that is encoded in the genome of human." [PRO:DNx, UniProtKB:Q9H9P2] comment: Category=organism-gene. synonym: "C21orf68" RELATED Gene-based [UniProtKB:Q9H9P2] synonym: "CHODL" RELATED Gene-based [UniProtKB:Q9H9P2] synonym: "hCHODL" EXACT PRO-short-label [PRO:DNx] synonym: "PRED12" RELATED Gene-based [UniProtKB:Q9H9P2] synonym: "transmembrane protein MT75 (human)" EXACT [UniProtKB:Q9H9P2] synonym: "UNQ872/PRO1890" RELATED Gene-based [UniProtKB:Q9H9P2] xref: UniProtKB:Q9H9P2 is_a: PR:000005444 ! chondrolectin is_a: PR:000029067 ! Homo sapiens protein intersection_of: PR:000005444 ! chondrolectin intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:Q9HBX9 name: relaxin receptor 1 (human) namespace: protein def: "A relaxin receptor 1 that is encoded in the genome of human." [PRO:WCB, UniProtKB:Q9HBX9] comment: Category=organism-gene. synonym: "hRXFP1" EXACT PRO-short-label [PRO:DNx] synonym: "leucine-rich repeat-containing G-protein coupled receptor 7 (human)" EXACT [UniProtKB:Q9HBX9] synonym: "LGR7" RELATED Gene-based [UniProtKB:Q9HBX9] synonym: "relaxin family peptide receptor 1 (human)" EXACT [UniProtKB:Q9HBX9] synonym: "RXFP1" RELATED Gene-based [UniProtKB:Q9HBX9] xref: DTO:02100761 xref: Reactome:R-HSA-444834 "PR:Q9HBX9 located_in GO:0005886" xref: UniProtKB:Q9HBX9 is_a: PR:000001666 ! relaxin receptor 1 is_a: PR:000029067 ! Homo sapiens protein intersection_of: PR:000001666 ! relaxin receptor 1 intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:Q9HCB6 name: spondin-1 (human) namespace: protein def: "A spondin-1 that is encoded in the genome of human." [PRO:DNx, UniProtKB:Q9HCB6] comment: Category=organism-gene. synonym: "F-spondin (human)" EXACT [UniProtKB:Q9HCB6] synonym: "hSPON1" EXACT PRO-short-label [PRO:DNx] synonym: "KIAA0762" RELATED Gene-based [UniProtKB:Q9HCB6] synonym: "SPON1" RELATED Gene-based [UniProtKB:Q9HCB6] synonym: "vascular smooth muscle cell growth-promoting factor (human)" EXACT [UniProtKB:Q9HCB6] synonym: "VSGP" RELATED Gene-based [UniProtKB:Q9HCB6] xref: UniProtKB:Q9HCB6 is_a: PR:000015557 ! spondin-1 is_a: PR:000029067 ! Homo sapiens protein intersection_of: PR:000015557 ! spondin-1 intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:Q9JIP3 name: interleukin-17 receptor B (mouse) namespace: protein def: "An interleukin-17 receptor B that is encoded in the genome of mouse." [OMA:Q9JIP3, PRO:DNx] comment: Category=organism-gene. synonym: "Evi27" RELATED Gene-based [UniProtKB:Q9JIP3] synonym: "IL-17 receptor B (mouse)" EXACT [UniProtKB:Q9JIP3] synonym: "IL-17 receptor homolog 1 (mouse)" EXACT [UniProtKB:Q9JIP3] synonym: "IL-17B receptor (mouse)" EXACT [UniProtKB:Q9JIP3] synonym: "IL-17ER (mouse)" EXACT [UniProtKB:Q9JIP3] synonym: "IL-17RB (mouse)" EXACT [UniProtKB:Q9JIP3] synonym: "IL-17Rh1 (mouse)" EXACT [UniProtKB:Q9JIP3] synonym: "Il17br" RELATED Gene-based [UniProtKB:Q9JIP3] synonym: "Il17rb" RELATED Gene-based [UniProtKB:Q9JIP3] synonym: "IL17Rh1 (mouse)" EXACT [UniProtKB:Q9JIP3] synonym: "interleukin-17B receptor (mouse)" EXACT [UniProtKB:Q9JIP3] synonym: "mIL17RB" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:Q9JIP3 is_a: PR:000008982 ! interleukin-17 receptor B is_a: PR:000029032 ! Mus musculus protein intersection_of: PR:000008982 ! interleukin-17 receptor B intersection_of: RO:0002160 NCBITaxon:10090 ! only in taxon Mus musculus [Term] id: PR:Q9JKD8 name: T-box transcription factor TBX21 (mouse) namespace: protein def: "A T-box transcription factor TBX21 that is encoded in the genome of mouse." [OMA:Q9JKD8, PRO:DNx] comment: Category=organism-gene. synonym: "mTBX21" EXACT PRO-short-label [PRO:DNx] synonym: "T-box protein 21 (mouse)" EXACT [UniProtKB:Q9JKD8] synonym: "T-cell-specific T-box transcription factor T-bet (mouse)" EXACT [UniProtKB:Q9JKD8] synonym: "Tbet" RELATED Gene-based [UniProtKB:Q9JKD8] synonym: "Tblym" RELATED Gene-based [UniProtKB:Q9JKD8] synonym: "Tbx21" RELATED Gene-based [UniProtKB:Q9JKD8] synonym: "transcription factor TBLYM (mouse)" EXACT [UniProtKB:Q9JKD8] xref: UniProtKB:Q9JKD8 is_a: PR:000001835 ! T-box transcription factor TBX21 is_a: PR:000029032 ! Mus musculus protein intersection_of: PR:000001835 ! T-box transcription factor TBX21 intersection_of: RO:0002160 NCBITaxon:10090 ! only in taxon Mus musculus [Term] id: PR:Q9JKF4 name: C-type lectin domain family 6 member A (mouse) namespace: protein def: "A C-type lectin domain family 6 member A that is encoded in the genome of mouse." [OMA:Q9JKF4, PRO:DNx] comment: Category=organism-gene. synonym: "C-type lectin superfamily member 10 (mouse)" EXACT [UniProtKB:Q9JKF4] synonym: "Clec4n" RELATED Gene-based [UniProtKB:Q9JKF4] synonym: "Clec6a" RELATED Gene-based [UniProtKB:Q9JKF4] synonym: "Clecsf10" RELATED Gene-based [UniProtKB:Q9JKF4] synonym: "DC-associated C-type lectin 2 (mouse)" EXACT [UniProtKB:Q9JKF4] synonym: "dectin-2 (mouse)" EXACT [UniProtKB:Q9JKF4] synonym: "Dectin2" RELATED Gene-based [UniProtKB:Q9JKF4] synonym: "dendritic cell-associated C-type lectin 2 (mouse)" EXACT [UniProtKB:Q9JKF4] synonym: "mCLEC6A" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:Q9JKF4 is_a: PR:000001806 ! C-type lectin domain family 6 member A is_a: PR:000029032 ! Mus musculus protein intersection_of: PR:000001806 ! C-type lectin domain family 6 member A intersection_of: RO:0002160 NCBITaxon:10090 ! only in taxon Mus musculus [Term] id: PR:Q9JLV1 name: BAG family molecular chaperone regulator 3 (mouse) namespace: protein def: "A BAG family molecular chaperone regulator 3 that is encoded in the genome of mouse." [OMA:Q9JLV1, PRO:DNx] comment: Category=organism-gene. synonym: "BAG-3 (mouse)" EXACT [UniProtKB:Q9JLV1] synonym: "Bag3" RELATED Gene-based [UniProtKB:Q9JLV1] synonym: "Bcl-2-associated athanogene 3 (mouse)" EXACT [UniProtKB:Q9JLV1] synonym: "Bcl-2-binding protein Bis (mouse)" EXACT [UniProtKB:Q9JLV1] synonym: "Bis" RELATED Gene-based [UniProtKB:Q9JLV1] synonym: "mBAG3" EXACT PRO-short-label [PRO:DNx] synonym: "MNCb-2243" RELATED Gene-based [UniProtKB:Q9JLV1] xref: UniProtKB:Q9JLV1 is_a: PR:000004621 ! BAG family molecular chaperone regulator 3 is_a: PR:000029032 ! Mus musculus protein intersection_of: PR:000004621 ! BAG family molecular chaperone regulator 3 intersection_of: RO:0002160 NCBITaxon:10090 ! only in taxon Mus musculus [Term] id: PR:Q9NNX6 name: CD209 antigen (human) namespace: protein def: "A CD209 molecule that is encoded in the genome of human." [PRO:WCB, UniProtKB:Q9NNX6] comment: Category=organism-gene. synonym: "C-type lectin domain family 4 member L (human)" EXACT [UniProtKB:Q9NNX6] synonym: "CD209" RELATED Gene-based [UniProtKB:Q9NNX6] synonym: "CLEC4L" RELATED Gene-based [UniProtKB:Q9NNX6] synonym: "DC-SIGN (human)" EXACT [UniProtKB:Q9NNX6] synonym: "DC-SIGN1 (human)" EXACT [UniProtKB:Q9NNX6] synonym: "dendritic cell-specific ICAM-3-grabbing non-integrin 1 (human)" EXACT [UniProtKB:Q9NNX6] synonym: "hCD209" EXACT PRO-short-label [PRO:DNx] xref: Reactome:R-HSA-2079928 "PR:Q9NNX6 located_in GO:0005886" xref: UniProtKB:Q9NNX6 is_a: PR:000001300 ! CD209 molecule is_a: PR:000029067 ! Homo sapiens protein intersection_of: PR:000001300 ! CD209 molecule intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:Q9NPC4 name: lactosylceramide 4-alpha-galactosyltransferase (human) namespace: protein def: "A lactosylceramide 4-alpha-galactosyltransferase that is encoded in the genome of human." [PRO:DNx, UniProtKB:Q9NPC4] comment: Category=organism-gene. synonym: "A14GALT" RELATED Gene-based [UniProtKB:Q9NPC4] synonym: "A4GALT" RELATED Gene-based [UniProtKB:Q9NPC4] synonym: "A4GALT1" RELATED Gene-based [UniProtKB:Q9NPC4] synonym: "alpha-1,4-galactosyltransferase (human)" EXACT [UniProtKB:Q9NPC4] synonym: "alpha-1,4-N-acetylglucosaminyltransferase (human)" RELATED [UniProtKB:Q9NPC4] synonym: "alpha4Gal-T1 (human)" EXACT [UniProtKB:Q9NPC4] synonym: "CD77 synthase (human)" EXACT [UniProtKB:Q9NPC4] synonym: "Gb3 synthase (human)" EXACT [UniProtKB:Q9NPC4] synonym: "globotriaosylceramide synthase (human)" EXACT [UniProtKB:Q9NPC4] synonym: "hA4GALT" EXACT PRO-short-label [PRO:DNx] synonym: "P1/Pk synthase (human)" EXACT [UniProtKB:Q9NPC4] synonym: "UDP-galactose:beta-D-galactosyl-beta1-R 4-alpha-D-galactosyltransferase (human)" EXACT [UniProtKB:Q9NPC4] xref: UniProtKB:Q9NPC4 is_a: PR:000003516 ! lactosylceramide 4-alpha-galactosyltransferase is_a: PR:000029067 ! Homo sapiens protein intersection_of: PR:000003516 ! lactosylceramide 4-alpha-galactosyltransferase intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:Q9NPY3 name: complement component C1q receptor (human) namespace: protein def: "A complement component C1q receptor that is encoded in the genome of human." [PRO:WCB, UniProtKB:Q9NPY3] comment: Category=organism-gene. synonym: "C1q/MBL/SPA receptor (human)" EXACT [UniProtKB:Q9NPY3] synonym: "C1qR (human)" EXACT [UniProtKB:Q9NPY3] synonym: "C1qR(p) (human)" EXACT [UniProtKB:Q9NPY3] synonym: "C1QR1" RELATED Gene-based [UniProtKB:Q9NPY3] synonym: "C1qRp (human)" EXACT [UniProtKB:Q9NPY3] synonym: "CD93" RELATED Gene-based [UniProtKB:Q9NPY3] synonym: "CDw93 (human)" EXACT [UniProtKB:Q9NPY3] synonym: "complement component 1 q subcomponent receptor 1 (human)" EXACT [UniProtKB:Q9NPY3] synonym: "hCD93" EXACT PRO-short-label [PRO:DNx] synonym: "matrix-remodeling-associated protein 4 (human)" EXACT [UniProtKB:Q9NPY3] synonym: "MXRA4" RELATED Gene-based [UniProtKB:Q9NPY3] xref: UniProtKB:Q9NPY3 is_a: PR:000002037 ! complement component C1q receptor is_a: PR:000029067 ! Homo sapiens protein intersection_of: PR:000002037 ! complement component C1q receptor intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:Q9NRM6 name: interleukin-17 receptor B (human) namespace: protein def: "An interleukin-17 receptor B that is encoded in the genome of human." [PRO:DNx, UniProtKB:Q9NRM6] comment: Category=organism-gene. synonym: "CRL4" RELATED Gene-based [UniProtKB:Q9NRM6] synonym: "cytokine receptor-like 4 (human)" EXACT [UniProtKB:Q9NRM6] synonym: "EVI27" RELATED Gene-based [UniProtKB:Q9NRM6] synonym: "hIL17RB" EXACT PRO-short-label [PRO:DNx] synonym: "IL-17 receptor B (human)" EXACT [UniProtKB:Q9NRM6] synonym: "IL-17 receptor homolog 1 (human)" EXACT [UniProtKB:Q9NRM6] synonym: "IL-17B receptor (human)" EXACT [UniProtKB:Q9NRM6] synonym: "IL-17RB (human)" EXACT [UniProtKB:Q9NRM6] synonym: "IL-17Rh1 (human)" EXACT [UniProtKB:Q9NRM6] synonym: "IL17BR" RELATED Gene-based [UniProtKB:Q9NRM6] synonym: "IL17RB" RELATED Gene-based [UniProtKB:Q9NRM6] synonym: "IL17Rh1 (human)" EXACT [UniProtKB:Q9NRM6] synonym: "interleukin-17B receptor (human)" EXACT [UniProtKB:Q9NRM6] synonym: "UNQ2501/PRO19612" RELATED Gene-based [UniProtKB:Q9NRM6] xref: UniProtKB:Q9NRM6 is_a: PR:000008982 ! interleukin-17 receptor B is_a: PR:000029067 ! Homo sapiens protein intersection_of: PR:000008982 ! interleukin-17 receptor B intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:Q9NZC2 name: triggering receptor expressed on myeloid cells 2 (human) namespace: protein def: "A triggering receptor expressed on myeloid cells 2 that is encoded in the genome of human." [PRO:DNx, UniProtKB:Q9NZC2] comment: Category=organism-gene. Requested by=Alzforum. synonym: "hTREM2" EXACT PRO-short-label [PRO:DNx] synonym: "TREM-2 (human)" EXACT [UniProtKB:Q9NZC2] synonym: "TREM2" RELATED Gene-based [UniProtKB:Q9NZC2] synonym: "triggering receptor expressed on monocytes 2 (human)" EXACT [UniProtKB:Q9NZC2] xref: UniProtKB:Q9NZC2 is_a: PR:000016626 ! triggering receptor expressed on myeloid cells 2 is_a: PR:000029067 ! Homo sapiens protein intersection_of: PR:000016626 ! triggering receptor expressed on myeloid cells 2 intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:Q9P2U8 name: vesicular glutamate transporter 2 (human) namespace: protein def: "A vesicular glutamate transporter 2 that is encoded in the genome of human." [PRO:DNx, UniProtKB:Q9P2U8] comment: Category=organism-gene. synonym: "differentiation-associated BNPI (human)" EXACT [UniProtKB:Q9P2U8] synonym: "differentiation-associated Na(+)-dependent inorganic phosphate cotransporter (human)" EXACT [UniProtKB:Q9P2U8] synonym: "DNPI" RELATED Gene-based [UniProtKB:Q9P2U8] synonym: "hSLC17A6" EXACT PRO-short-label [PRO:DNx] synonym: "SLC17A6" RELATED Gene-based [UniProtKB:Q9P2U8] synonym: "solute carrier family 17 member 6 (human)" EXACT [UniProtKB:Q9P2U8] synonym: "VGLUT2" RELATED Gene-based [UniProtKB:Q9P2U8] xref: Reactome:R-HSA-428644 "PR:Q9P2U8 located_in GO:0030672" xref: UniProtKB:Q9P2U8 is_a: PR:000014962 ! vesicular glutamate transporter 2 is_a: PR:000029067 ! Homo sapiens protein intersection_of: PR:000014962 ! vesicular glutamate transporter 2 intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:Q9P2W7 name: galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1 (human) namespace: protein def: "A galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1 that is encoded in the genome of human." [PRO:WCB, UniProtKB:Q9P2W7] comment: Category=organism-gene. synonym: "B3GAT1" RELATED Gene-based [UniProtKB:Q9P2W7] synonym: "beta-1,3-glucuronyltransferase 1 (human)" EXACT [UniProtKB:Q9P2W7] synonym: "GlcAT-P (human)" EXACT [] synonym: "GLCATP" RELATED Gene-based [UniProtKB:Q9P2W7] synonym: "GlcUAT-P (human)" EXACT [UniProtKB:Q9P2W7] synonym: "glucuronosyltransferase P (human)" EXACT [UniProtKB:Q9P2W7] synonym: "hB3GAT1" EXACT PRO-short-label [PRO:DNx] synonym: "UDP-GlcUA:glycoprotein beta-1,3-glucuronyltransferase (human)" EXACT [UniProtKB:Q9P2W7] xref: Reactome:R-HSA-1889953 "PR:Q9P2W7 located_in GO:0000139" xref: UniProtKB:Q9P2W7 is_a: PR:000001440 ! galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1 is_a: PR:000029067 ! Homo sapiens protein intersection_of: PR:000001440 ! galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1 intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:Q9QUM0 name: integrin alpha-IIb (mouse) namespace: protein def: "An integrin alpha-IIb that is encoded in the genome of mouse." [OMA:Q9QUM0, PRO:DNx] comment: Category=organism-gene. synonym: "CD41 (mouse)" EXACT [UniProtKB:Q9QUM0] synonym: "GPalpha IIb (mouse)" EXACT [UniProtKB:Q9QUM0] synonym: "GPIIb (mouse)" EXACT [UniProtKB:Q9QUM0] synonym: "Itga2b" RELATED Gene-based [UniProtKB:Q9QUM0] synonym: "mITGA2B" EXACT PRO-short-label [PRO:DNx] synonym: "platelet membrane glycoprotein IIb (mouse)" EXACT [UniProtKB:Q9QUM0] xref: UniProtKB:Q9QUM0 is_a: PR:000009127 ! integrin alpha-IIb is_a: PR:000029032 ! Mus musculus protein intersection_of: PR:000009127 ! integrin alpha-IIb intersection_of: RO:0002160 NCBITaxon:10090 ! only in taxon Mus musculus [Term] id: PR:Q9QUM4 name: signaling lymphocytic activation molecule (mouse) namespace: protein def: "A SLAM family member 1 that is encoded in the genome of mouse." [OMA:Q9QUM4, PRO:DNx] comment: Category=organism-gene. synonym: "CD150 (mouse)" EXACT [UniProtKB:Q9QUM4] synonym: "mSLAMF1" EXACT PRO-short-label [PRO:DNx] synonym: "Slam" RELATED Gene-based [UniProtKB:Q9QUM4] synonym: "SLAM family member 1 (mouse)" EXACT [UniProtKB:Q9QUM4] synonym: "Slamf1" RELATED Gene-based [UniProtKB:Q9QUM4] xref: UniProtKB:Q9QUM4 is_a: PR:000001833 ! SLAM family member 1 is_a: PR:000029032 ! Mus musculus protein intersection_of: PR:000001833 ! SLAM family member 1 intersection_of: RO:0002160 NCBITaxon:10090 ! only in taxon Mus musculus [Term] id: PR:Q9QXH4 name: integrin alpha-X (mouse) namespace: protein def: "An integrin alpha-X that is encoded in the genome of mouse." [OMA:Q9QXH4, PRO:DNx] comment: Category=organism-gene. synonym: "CD11 antigen-like family member C (mouse)" EXACT [UniProtKB:Q9QXH4] synonym: "CD11c (mouse)" EXACT [UniProtKB:Q9QXH4] synonym: "Itgax" RELATED Gene-based [UniProtKB:Q9QXH4] synonym: "leukocyte adhesion glycoprotein p150,95 alpha chain (mouse)" EXACT [UniProtKB:Q9QXH4] synonym: "leukocyte adhesion receptor p150,95 (mouse)" EXACT [UniProtKB:Q9QXH4] synonym: "mITGAX" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:Q9QXH4 is_a: PR:000001013 ! integrin alpha-X is_a: PR:000029032 ! Mus musculus protein intersection_of: PR:000001013 ! integrin alpha-X intersection_of: RO:0002160 NCBITaxon:10090 ! only in taxon Mus musculus [Term] id: PR:Q9QXZ9 name: melanopsin (mouse) namespace: protein def: "A melanopsin that is encoded in the genome of mouse." [OMA:Q9QXZ9, PRO:DNx] comment: Category=organism-gene. synonym: "Mop" RELATED Gene-based [UniProtKB:Q9QXZ9] synonym: "Mopn" RELATED Gene-based [UniProtKB:Q9QXZ9] synonym: "mOPN4" EXACT PRO-short-label [PRO:DNx] synonym: "Opn4" RELATED Gene-based [UniProtKB:Q9QXZ9] synonym: "opsin-4 (mouse)" EXACT [UniProtKB:Q9QXZ9] xref: UniProtKB:Q9QXZ9 is_a: PR:000001243 ! melanopsin is_a: PR:000029032 ! Mus musculus protein intersection_of: PR:000001243 ! melanopsin intersection_of: RO:0002160 NCBITaxon:10090 ! only in taxon Mus musculus [Term] id: PR:Q9QYM9 name: tomoregulin-2 (mouse) namespace: protein def: "A tomoregulin-2 that is encoded in the genome of mouse." [OMA:Q9QYM9, PRO:DNx] comment: Category=organism-gene. synonym: "MNCb-1026" RELATED Gene-based [UniProtKB:Q9QYM9] synonym: "mTMEFF2" EXACT PRO-short-label [PRO:DNx] synonym: "Tmeff2" RELATED Gene-based [UniProtKB:Q9QYM9] synonym: "TR-2 (mouse)" EXACT [UniProtKB:Q9QYM9] synonym: "transmembrane protein with EGF-like and two follistatin-like domains (mouse)" EXACT [UniProtKB:Q9QYM9] xref: UniProtKB:Q9QYM9 is_a: PR:000016407 ! tomoregulin-2 is_a: PR:000029032 ! Mus musculus protein intersection_of: PR:000016407 ! tomoregulin-2 intersection_of: RO:0002160 NCBITaxon:10090 ! only in taxon Mus musculus [Term] id: PR:Q9R053 name: sodium channel protein type 11 subunit alpha (mouse) namespace: protein def: "A sodium channel protein type 11 subunit alpha that is encoded in the genome of mouse." [OMA:Q9R053, PRO:DNx] comment: Category=organism-gene. synonym: "mSCN11A" EXACT PRO-short-label [PRO:DNx] synonym: "Nan" RELATED Gene-based [UniProtKB:Q9R053] synonym: "NaN (mouse)" EXACT [UniProtKB:Q9R053] synonym: "Nat" RELATED Gene-based [UniProtKB:Q9R053] synonym: "Scn11a" RELATED Gene-based [UniProtKB:Q9R053] synonym: "sensory neuron sodium channel 2 (mouse)" EXACT [UniProtKB:Q9R053] synonym: "Sns2" RELATED Gene-based [UniProtKB:Q9R053] synonym: "sodium channel protein type XI subunit alpha (mouse)" EXACT [UniProtKB:Q9R053] synonym: "voltage-gated sodium channel subunit alpha Nav1.9 (mouse)" EXACT [UniProtKB:Q9R053] xref: UniProtKB:Q9R053 is_a: PR:000002097 ! sodium channel protein type 11 subunit alpha is_a: PR:000029032 ! Mus musculus protein intersection_of: PR:000002097 ! sodium channel protein type 11 subunit alpha intersection_of: RO:0002160 NCBITaxon:10090 ! only in taxon Mus musculus [Term] id: PR:Q9R1R0 name: LIM/homeobox protein Lhx6 (mouse) namespace: protein def: "A LIM/homeobox protein Lhx6 that is encoded in the genome of mouse." [OMA:Q9R1R0, PRO:DNx] comment: Category=organism-gene. synonym: "Lhx6" RELATED Gene-based [UniProtKB:Q9R1R0] synonym: "Lhx6.1" RELATED Gene-based [UniProtKB:Q9R1R0] synonym: "LIM homeobox protein 6 (mouse)" EXACT [UniProtKB:Q9R1R0] synonym: "LIM/homeobox protein Lhx6.1 (mouse)" EXACT [UniProtKB:Q9R1R0] synonym: "mLHX6" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:Q9R1R0 is_a: PR:000029032 ! Mus musculus protein is_a: PR:000032533 ! LIM/homeobox protein Lhx6 intersection_of: PR:000032533 ! LIM/homeobox protein Lhx6 intersection_of: RO:0002160 NCBITaxon:10090 ! only in taxon Mus musculus [Term] id: PR:Q9R1W5 name: calcitonin gene-related peptide type 1 receptor (mouse) namespace: protein def: "A calcitonin gene-related peptide type 1 receptor that is encoded in the genome of mouse." [OMA:Q9R1W5, PRO:DNx] comment: Category=organism-gene. synonym: "calcitonin receptor-like receptor (mouse)" EXACT [UniProtKB:Q9R1W5] synonym: "Calcrl" RELATED Gene-based [UniProtKB:Q9R1W5] synonym: "CGRP type 1 receptor (mouse)" EXACT [UniProtKB:Q9R1W5] synonym: "Crlr" RELATED Gene-based [UniProtKB:Q9R1W5] synonym: "mCALCRL" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:Q9R1W5 is_a: PR:000004973 ! calcitonin gene-related peptide type 1 receptor is_a: PR:000029032 ! Mus musculus protein intersection_of: PR:000004973 ! calcitonin gene-related peptide type 1 receptor intersection_of: RO:0002160 NCBITaxon:10090 ! only in taxon Mus musculus [Term] id: PR:Q9UBR4 name: LIM/homeobox protein Lhx3 (human) namespace: protein def: "A LIM/homeobox protein Lhx3 that is encoded in the genome of human." [PRO:DNx, UniProtKB:Q9UBR4] comment: Category=organism-gene. synonym: "hLHX3" EXACT PRO-short-label [PRO:DNx] synonym: "LHX3" RELATED Gene-based [UniProtKB:Q9UBR4] synonym: "LIM homeobox protein 3 (human)" EXACT [UniProtKB:Q9UBR4] xref: Reactome:R-HSA-9010582 "PR:Q9UBR4 located_in GO:0005654" xref: UniProtKB:Q9UBR4 is_a: PR:000009793 ! LIM/homeobox protein Lhx3 is_a: PR:000029067 ! Homo sapiens protein intersection_of: PR:000009793 ! LIM/homeobox protein Lhx3 intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:Q9UEW3 name: macrophage receptor MARCO (human) namespace: protein def: "A macrophage receptor MARCO that is encoded in the genome of human." [PRO:WCB, UniProtKB:Q9UEW3] comment: Category=organism-gene. synonym: "hMARCO" EXACT PRO-short-label [PRO:DNx] synonym: "macrophage receptor with collagenous structure (human)" EXACT [UniProtKB:Q9UEW3] synonym: "MARCO" RELATED Gene-based [UniProtKB:Q9UEW3] synonym: "SCARA2" RELATED Gene-based [UniProtKB:Q9UEW3] synonym: "scavenger receptor class A member 2 (human)" EXACT [UniProtKB:Q9UEW3] xref: UniProtKB:Q9UEW3 is_a: PR:000001884 ! macrophage receptor MARCO is_a: PR:000029067 ! Homo sapiens protein intersection_of: PR:000001884 ! macrophage receptor MARCO intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:Q9UHF0 name: tachykinin-3 (human) namespace: protein def: "A tachykinin-3 that is encoded in the genome of human." [PRO:DNx, UniProtKB:Q9UHF0] comment: Category=organism-gene. synonym: "hTAC3" EXACT PRO-short-label [PRO:DNx] synonym: "NKNB" RELATED Gene-based [UniProtKB:Q9UHF0] synonym: "TAC3" RELATED Gene-based [UniProtKB:Q9UHF0] synonym: "UNQ585/PRO1155" RELATED Gene-based [UniProtKB:Q9UHF0] synonym: "ZNEUROK1 (human)" EXACT [UniProtKB:Q9UHF0] xref: UniProtKB:Q9UHF0 is_a: PR:000016004 ! tachykinin-3 is_a: PR:000029067 ! Homo sapiens protein intersection_of: PR:000016004 ! tachykinin-3 intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:Q9UHM6 name: melanopsin (human) namespace: protein def: "A melanopsin that is encoded in the genome of human." [PRO:WCB, UniProtKB:Q9UHM6] comment: Category=organism-gene. synonym: "hOPN4" EXACT PRO-short-label [PRO:DNx] synonym: "MOP" RELATED Gene-based [UniProtKB:Q9UHM6] synonym: "OPN4" RELATED Gene-based [UniProtKB:Q9UHM6] synonym: "opsin-4 (human)" EXACT [UniProtKB:Q9UHM6] xref: DTO:02100466 xref: Reactome:R-HSA-391825 "PR:Q9UHM6 located_in GO:0005886" xref: UniProtKB:Q9UHM6 is_a: PR:000001243 ! melanopsin is_a: PR:000029067 ! Homo sapiens protein intersection_of: PR:000001243 ! melanopsin intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:Q9UI33 name: sodium channel protein type 11 subunit alpha (human) namespace: protein def: "A sodium channel protein type 11 subunit alpha that is encoded in the genome of human." [PRO:WCB, UniProtKB:Q9UI33] comment: Category=organism-gene. synonym: "hNaN" EXACT [UniProtKB:Q9UI33] synonym: "hSCN11A" EXACT PRO-short-label [PRO:DNx] synonym: "peripheral nerve sodium channel 5 (human)" EXACT [UniProtKB:Q9UI33] synonym: "PN5 (human)" EXACT [UniProtKB:Q9UI33] synonym: "SCN11A" RELATED Gene-based [UniProtKB:Q9UI33] synonym: "SCN12A" RELATED Gene-based [UniProtKB:Q9UI33] synonym: "sensory neuron sodium channel 2 (human)" EXACT [UniProtKB:Q9UI33] synonym: "SNS2" RELATED Gene-based [UniProtKB:Q9UI33] synonym: "sodium channel protein type XI subunit alpha (human)" EXACT [UniProtKB:Q9UI33] synonym: "voltage-gated sodium channel subunit alpha Nav1.9 (human)" EXACT [UniProtKB:Q9UI33] xref: DTO:01100302 xref: Reactome:R-HSA-2671896 "PR:Q9UI33 located_in GO:0005886" xref: UniProtKB:Q9UI33 is_a: PR:000002097 ! sodium channel protein type 11 subunit alpha is_a: PR:000029067 ! Homo sapiens protein intersection_of: PR:000002097 ! sodium channel protein type 11 subunit alpha intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:Q9UIB8 name: SLAM family member 5 (human) namespace: protein def: "A SLAM family member 5 that is encoded in the genome of human." [PRO:WCB, UniProtKB:Q9UIB8] comment: Category=organism-gene. synonym: "CD84" RELATED Gene-based [UniProtKB:Q9UIB8] synonym: "cell surface antigen MAX.3 (human)" EXACT [UniProtKB:Q9UIB8] synonym: "hCD84" EXACT PRO-short-label [PRO:DNx] synonym: "Hly9-beta (human)" EXACT [UniProtKB:Q9UIB8] synonym: "leukocyte differentiation antigen CD84 (human)" EXACT [UniProtKB:Q9UIB8] synonym: "signaling lymphocytic activation molecule 5 (human)" EXACT [UniProtKB:Q9UIB8] synonym: "SLAMF5" RELATED Gene-based [UniProtKB:Q9UIB8] xref: UniProtKB:Q9UIB8 is_a: PR:000001319 ! SLAM family member 5 is_a: PR:000029067 ! Homo sapiens protein intersection_of: PR:000001319 ! SLAM family member 5 intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:Q9UIK5 name: tomoregulin-2 (human) namespace: protein def: "A tomoregulin-2 that is encoded in the genome of human." [PRO:DNx, UniProtKB:Q9UIK5] comment: Category=organism-gene. synonym: "HPP1" RELATED Gene-based [UniProtKB:Q9UIK5] synonym: "hTMEFF2" EXACT PRO-short-label [PRO:DNx] synonym: "hyperplastic polyposis protein 1 (human)" EXACT [UniProtKB:Q9UIK5] synonym: "TENB2" RELATED Gene-based [UniProtKB:Q9UIK5] synonym: "TMEFF2" RELATED Gene-based [UniProtKB:Q9UIK5] synonym: "TPEF" RELATED Gene-based [UniProtKB:Q9UIK5] synonym: "TR-2 (human)" EXACT [UniProtKB:Q9UIK5] synonym: "transmembrane protein with EGF-like and two follistatin-like domains (human)" EXACT [UniProtKB:Q9UIK5] synonym: "UNQ178/PRO204" RELATED Gene-based [UniProtKB:Q9UIK5] xref: UniProtKB:Q9UIK5 is_a: PR:000016407 ! tomoregulin-2 is_a: PR:000029067 ! Homo sapiens protein intersection_of: PR:000016407 ! tomoregulin-2 intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:Q9UJ71 name: C-type lectin domain family 4 member K (human) namespace: protein def: "A C-type lectin domain family 4 member K that is encoded in the genome of human." [PRO:WCB, UniProtKB:Q9UJ71] comment: Category=organism-gene. synonym: "CD207" RELATED Gene-based [UniProtKB:Q9UJ71] synonym: "CLEC4K" RELATED Gene-based [UniProtKB:Q9UJ71] synonym: "hCD207" EXACT PRO-short-label [PRO:DNx] synonym: "langerin (human)" EXACT [UniProtKB:Q9UJ71] xref: Reactome:R-HSA-1216519 "PR:Q9UJ71 located_in GO:0005886" xref: Reactome:R-HSA-1236762 "PR:Q9UJ71 located_in GO:0030669" xref: Reactome:R-HSA-1236852 "PR:Q9UJ71 located_in GO:0031901" xref: UniProtKB:Q9UJ71 is_a: PR:000001293 ! C-type lectin domain family 4 member K is_a: PR:000029067 ! Homo sapiens protein intersection_of: PR:000001293 ! C-type lectin domain family 4 member K intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:Q9UJQ1 name: lysosome-associated membrane glycoprotein 5 (human) namespace: protein def: "A lysosome-associated membrane glycoprotein 5 that is encoded in the genome of human." [PRO:DNx, UniProtKB:Q9UJQ1] comment: Category=organism-gene. synonym: "BAD-LAMP (human)" EXACT [UniProtKB:Q9UJQ1] synonym: "brain and dendritic cell-associated LAMP (human)" EXACT [UniProtKB:Q9UJQ1] synonym: "brain-associated LAMP-like protein (human)" EXACT [UniProtKB:Q9UJQ1] synonym: "C20orf103" RELATED Gene-based [UniProtKB:Q9UJQ1] synonym: "hLAMP5" EXACT PRO-short-label [PRO:DNx] synonym: "LAMP-5 (human)" EXACT [UniProtKB:Q9UJQ1] synonym: "LAMP5" RELATED Gene-based [UniProtKB:Q9UJQ1] synonym: "lysosome-associated membrane protein 5 (human)" EXACT [UniProtKB:Q9UJQ1] xref: UniProtKB:Q9UJQ1 is_a: PR:000029067 ! Homo sapiens protein is_a: PR:000032148 ! lysosome-associated membrane glycoprotein 5 intersection_of: PR:000032148 ! lysosome-associated membrane glycoprotein 5 intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:Q9UL17 name: T-box transcription factor TBX21 (human) namespace: protein def: "A T-box transcription factor TBX21 that is encoded in the genome of human." [PRO:WCB, UniProtKB:Q9UL17] comment: Category=organism-gene. synonym: "hTBX21" EXACT PRO-short-label [PRO:DNx] synonym: "T-box protein 21 (human)" EXACT [UniProtKB:Q9UL17] synonym: "T-cell-specific T-box transcription factor T-bet (human)" EXACT [UniProtKB:Q9UL17] synonym: "TBET" RELATED Gene-based [UniProtKB:Q9UL17] synonym: "TBLYM" RELATED Gene-based [UniProtKB:Q9UL17] synonym: "TBX21" RELATED Gene-based [UniProtKB:Q9UL17] synonym: "transcription factor TBLYM (human)" EXACT [UniProtKB:Q9UL17] xref: UniProtKB:Q9UL17 is_a: PR:000001835 ! T-box transcription factor TBX21 is_a: PR:000029067 ! Homo sapiens protein intersection_of: PR:000001835 ! T-box transcription factor TBX21 intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:Q9UPM6 name: LIM/homeobox protein Lhx6 (human) namespace: protein def: "A LIM/homeobox protein Lhx6 that is encoded in the genome of human." [PRO:DNx, UniProtKB:Q9UPM6] comment: Category=organism-gene. synonym: "hLHX6" EXACT PRO-short-label [PRO:DNx] synonym: "LHX6" RELATED Gene-based [UniProtKB:Q9UPM6] synonym: "LHX6.1" RELATED Gene-based [UniProtKB:Q9UPM6] synonym: "LIM homeobox protein 6 (human)" EXACT [UniProtKB:Q9UPM6] synonym: "LIM/homeobox protein Lhx6.1 (human)" EXACT [UniProtKB:Q9UPM6] xref: UniProtKB:Q9UPM6 is_a: PR:000029067 ! Homo sapiens protein is_a: PR:000032533 ! LIM/homeobox protein Lhx6 intersection_of: PR:000032533 ! LIM/homeobox protein Lhx6 intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:Q9WTK5 name: nuclear factor NF-kappa-B p100 subunit (mouse) namespace: protein def: "A nuclear factor NF-kappa-B p100 subunit that is encoded in the genome of mouse." [OMA:Q9WTK5, PRO:DNx] comment: Category=organism-gene. synonym: "DNA-binding factor KBF2 (mouse)" EXACT [UniProtKB:Q9WTK5] synonym: "mNFKB2" EXACT PRO-short-label [PRO:DNx] synonym: "Nfkb2" RELATED Gene-based [UniProtKB:Q9WTK5] synonym: "nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (mouse)" EXACT [UniProtKB:Q9WTK5] xref: UniProtKB:Q9WTK5 is_a: PR:000011178 ! nuclear factor NF-kappa-B p100 subunit is_a: PR:000029032 ! Mus musculus protein intersection_of: PR:000011178 ! nuclear factor NF-kappa-B p100 subunit intersection_of: RO:0002160 NCBITaxon:10090 ! only in taxon Mus musculus [Term] id: PR:Q9WTR1 name: transient receptor potential cation channel subfamily V member 2 (mouse) namespace: protein def: "A transient receptor potential cation channel TRPV2 that is encoded in the genome of mouse." [OMA:Q9WTR1, PRO:DNx] comment: Category=organism-gene. synonym: "Grc" RELATED Gene-based [UniProtKB:Q9WTR1] synonym: "GRC (mouse)" EXACT [UniProtKB:Q9WTR1] synonym: "growth factor-regulated calcium channel (mouse)" EXACT [UniProtKB:Q9WTR1] synonym: "mTRPV2" EXACT PRO-short-label [PRO:DNx] synonym: "Osm-9-like TRP channel 2 (mouse)" EXACT [UniProtKB:Q9WTR1] synonym: "OTRPC2 (mouse)" EXACT [UniProtKB:Q9WTR1] synonym: "Trpv2" RELATED Gene-based [UniProtKB:Q9WTR1] synonym: "TrpV2 (mouse)" EXACT [UniProtKB:Q9WTR1] xref: UniProtKB:Q9WTR1 is_a: PR:000001064 ! transient receptor potential cation channel TRPV2 is_a: PR:000029032 ! Mus musculus protein intersection_of: PR:000001064 ! transient receptor potential cation channel TRPV2 intersection_of: RO:0002160 NCBITaxon:10090 ! only in taxon Mus musculus [Term] id: PR:Q9WVS0 name: inducible T-cell costimulator (mouse) namespace: protein def: "An inducible T-cell costimulator that is encoded in the genome of mouse." [OMA:Q9WVS0, PRO:DNx] comment: Category=organism-gene. synonym: "activation-inducible lymphocyte immunomediatory molecule (mouse)" EXACT [UniProtKB:Q9WVS0] synonym: "Ailim" RELATED Gene-based [UniProtKB:Q9WVS0] synonym: "CCLP (mouse)" EXACT [UniProtKB:Q9WVS0] synonym: "CD278 (mouse)" EXACT [UniProtKB:Q9WVS0] synonym: "CD28 and CTLA-4-like protein (mouse)" EXACT [UniProtKB:Q9WVS0] synonym: "CD28-related protein 1 (mouse)" EXACT [UniProtKB:Q9WVS0] synonym: "CRP-1 (mouse)" RELATED [UniProtKB:Q9WVS0] synonym: "Icos" RELATED Gene-based [UniProtKB:Q9WVS0] synonym: "mICOS" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:Q9WVS0 is_a: PR:000001860 ! inducible T-cell costimulator is_a: PR:000029032 ! Mus musculus protein intersection_of: PR:000001860 ! inducible T-cell costimulator intersection_of: RO:0002160 NCBITaxon:10090 ! only in taxon Mus musculus [Term] id: PR:Q9Y2I2 name: netrin-G1 (human) namespace: protein def: "A netrin-G1 that is encoded in the genome of human." [PRO:DNx, UniProtKB:Q9Y2I2] comment: Category=organism-gene. synonym: "hNTNG1" EXACT PRO-short-label [PRO:DNx] synonym: "KIAA0976" RELATED Gene-based [UniProtKB:Q9Y2I2] synonym: "laminet-1 (human)" EXACT [UniProtKB:Q9Y2I2] synonym: "LMNT1" RELATED Gene-based [UniProtKB:Q9Y2I2] synonym: "NTNG1" RELATED Gene-based [UniProtKB:Q9Y2I2] synonym: "UNQ571/PRO1133" RELATED Gene-based [UniProtKB:Q9Y2I2] xref: UniProtKB:Q9Y2I2 is_a: PR:000011467 ! netrin-G1 is_a: PR:000029067 ! Homo sapiens protein intersection_of: PR:000011467 ! netrin-G1 intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:Q9Y5S1 name: transient receptor potential cation channel subfamily V member 2 (human) namespace: protein def: "A transient receptor potential cation channel TRPV2 that is encoded in the genome of human." [PRO:CNA, UniProtKB:Q9Y5S1] comment: Category=organism-gene. synonym: "hTRPV2" EXACT PRO-short-label [PRO:DNx] synonym: "Osm-9-like TRP channel 2 (human)" EXACT [UniProtKB:Q9Y5S1] synonym: "OTRPC2 (human)" EXACT [UniProtKB:Q9Y5S1] synonym: "TRPV2" RELATED Gene-based [UniProtKB:Q9Y5S1] synonym: "TrpV2 (human)" EXACT [UniProtKB:Q9Y5S1] synonym: "vanilloid receptor-like protein 1 (human)" EXACT [UniProtKB:Q9Y5S1] synonym: "VRL" RELATED Gene-based [UniProtKB:Q9Y5S1] synonym: "VRL-1 (human)" EXACT [UniProtKB:Q9Y5S1] xref: DTO:01100334 xref: Reactome:R-HSA-2671909 "PR:Q9Y5S1 located_in GO:0005886" xref: UniProtKB:Q9Y5S1 is_a: PR:000001064 ! transient receptor potential cation channel TRPV2 is_a: PR:000029067 ! Homo sapiens protein intersection_of: PR:000001064 ! transient receptor potential cation channel TRPV2 intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:Q9Y5Y4 name: prostaglandin D2 receptor 2 (human) namespace: protein def: "A prostaglandin D2 receptor DP2 that is encoded in the genome of human." [PRO:WCB, UniProtKB:Q9Y5Y4] comment: Category=organism-gene. synonym: "CD294 (human)" EXACT [UniProtKB:Q9Y5Y4] synonym: "chemoattractant receptor-homologous molecule expressed on Th2 cells (human)" EXACT [UniProtKB:Q9Y5Y4] synonym: "CRTH2" RELATED Gene-based [UniProtKB:Q9Y5Y4] synonym: "DL1R" RELATED Gene-based [UniProtKB:Q9Y5Y4] synonym: "G-protein coupled receptor 44 (human)" EXACT [UniProtKB:Q9Y5Y4] synonym: "GPR44" RELATED Gene-based [UniProtKB:Q9Y5Y4] synonym: "hPTGDR2" EXACT PRO-short-label [PRO:DNx] synonym: "PTGDR2" RELATED Gene-based [UniProtKB:Q9Y5Y4] xref: DTO:02100741 xref: Reactome:R-HSA-416895 "PR:Q9Y5Y4 located_in GO:0005886" xref: UniProtKB:Q9Y5Y4 is_a: PR:000001547 ! prostaglandin D2 receptor DP2 is_a: PR:000029067 ! Homo sapiens protein intersection_of: PR:000001547 ! prostaglandin D2 receptor DP2 intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:Q9Y6Q6 name: tumor necrosis factor receptor superfamily member 11A (human) namespace: protein def: "A tumor necrosis factor receptor superfamily member 11A that is encoded in the genome of human." [PRO:WCB, UniProtKB:Q9Y6Q6] comment: Category=organism-gene. synonym: "CD265 (human)" EXACT [UniProtKB:Q9Y6Q6] synonym: "hTNFRSF11A" EXACT PRO-short-label [PRO:DNx] synonym: "ODFR (human)" EXACT [UniProtKB:Q9Y6Q6] synonym: "osteoclast differentiation factor receptor (human)" EXACT [UniProtKB:Q9Y6Q6] synonym: "RANK" RELATED Gene-based [UniProtKB:Q9Y6Q6] synonym: "receptor activator of NF-KB (human)" EXACT [UniProtKB:Q9Y6Q6] synonym: "TNFRSF11A" RELATED Gene-based [UniProtKB:Q9Y6Q6] xref: UniProtKB:Q9Y6Q6 is_a: PR:000001954 ! tumor necrosis factor receptor superfamily member 11A is_a: PR:000029067 ! Homo sapiens protein intersection_of: PR:000001954 ! tumor necrosis factor receptor superfamily member 11A intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:Q9Y6W8 name: inducible T-cell costimulator (human) namespace: protein def: "An inducible T-cell costimulator that is encoded in the genome of human." [PRO:WCB, UniProtKB:Q9Y6W8] comment: Category=organism-gene. synonym: "activation-inducible lymphocyte immunomediatory molecule (human)" EXACT [UniProtKB:Q9Y6W8] synonym: "AILIM" RELATED Gene-based [UniProtKB:Q9Y6W8] synonym: "CD278 (human)" EXACT [UniProtKB:Q9Y6W8] synonym: "hICOS" EXACT PRO-short-label [PRO:DNx] synonym: "ICOS" RELATED Gene-based [UniProtKB:Q9Y6W8] xref: UniProtKB:Q9Y6W8 is_a: PR:000001860 ! inducible T-cell costimulator is_a: PR:000029067 ! Homo sapiens protein intersection_of: PR:000001860 ! inducible T-cell costimulator intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens [Term] id: PR:Q9Z0D9 name: CX3C chemokine receptor 1 (mouse) namespace: protein def: "A CX3C chemokine receptor 1 that is encoded in the genome of mouse." [OMA:Q9Z0D9, PRO:DNx] comment: Category=organism-gene. synonym: "C-X3-C CKR-1 (mouse)" EXACT [UniProtKB:Q9Z0D9] synonym: "Cx3cr1" RELATED Gene-based [UniProtKB:Q9Z0D9] synonym: "CX3CR1 (mouse)" EXACT [UniProtKB:Q9Z0D9] synonym: "fractalkine receptor (mouse)" EXACT [UniProtKB:Q9Z0D9] synonym: "mCX3CR1" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:Q9Z0D9 is_a: PR:000001206 ! CX3C chemokine receptor 1 is_a: PR:000029032 ! Mus musculus protein intersection_of: PR:000001206 ! CX3C chemokine receptor 1 intersection_of: RO:0002160 NCBITaxon:10090 ! only in taxon Mus musculus [Term] id: PR:Q9Z0F7 name: gamma-synuclein (mouse) namespace: protein def: "A gamma-synuclein that is encoded in the genome of mouse." [OMA:Q9Z0F7, PRO:DNx] comment: Category=organism-gene. synonym: "mSNCG" EXACT PRO-short-label [PRO:DNx] synonym: "Persyn" RELATED Gene-based [UniProtKB:Q9Z0F7] synonym: "persyn (mouse)" EXACT [UniProtKB:Q9Z0F7] synonym: "Sncg" RELATED Gene-based [UniProtKB:Q9Z0F7] xref: UniProtKB:Q9Z0F7 is_a: PR:000015325 ! gamma-synuclein is_a: PR:000029032 ! Mus musculus protein intersection_of: PR:000015325 ! gamma-synuclein intersection_of: RO:0002160 NCBITaxon:10090 ! only in taxon Mus musculus [Term] id: PR:Q9Z0J4 name: nitric oxide synthase 1 (mouse) namespace: protein def: "A nitric oxide synthase 1 that is encoded in the genome of mouse." [OMA:Q9Z0J4, PRO:DNx] comment: Category=organism-gene. synonym: "bNOS (mouse)" EXACT [UniProtKB:Q9Z0J4] synonym: "constitutive NOS (mouse)" RELATED [UniProtKB:Q9Z0J4] synonym: "mNOS1" EXACT PRO-short-label [PRO:DNx] synonym: "N-NOS (mouse)" EXACT [UniProtKB:Q9Z0J4] synonym: "NC-NOS (mouse)" EXACT [UniProtKB:Q9Z0J4] synonym: "neuronal NOS (mouse)" EXACT [UniProtKB:Q9Z0J4] synonym: "nitric oxide synthase, brain (mouse)" EXACT [UniProtKB:Q9Z0J4] synonym: "nNOS (mouse)" EXACT [UniProtKB:Q9Z0J4] synonym: "NOS type I (mouse)" EXACT [UniProtKB:Q9Z0J4] synonym: "Nos1" RELATED Gene-based [UniProtKB:Q9Z0J4] synonym: "peptidyl-cysteine S-nitrosylase NOS1 (mouse)" EXACT [UniProtKB:Q9Z0J4] xref: UniProtKB:Q9Z0J4 is_a: PR:000011326 ! nitric oxide synthase 1 is_a: PR:000029032 ! Mus musculus protein intersection_of: PR:000011326 ! nitric oxide synthase 1 intersection_of: RO:0002160 NCBITaxon:10090 ! only in taxon Mus musculus [Term] id: PR:Q9Z2J6 name: prostaglandin D2 receptor 2 (mouse) namespace: protein def: "A prostaglandin D2 receptor DP2 that is encoded in the genome of mouse." [OMA:Q9Z2J6, PRO:DNx] comment: Category=organism-gene. synonym: "CD294 (mouse)" EXACT [UniProtKB:Q9Z2J6] synonym: "chemoattractant receptor-homologous molecule expressed on Th2 cells (mouse)" EXACT [UniProtKB:Q9Z2J6] synonym: "Crth2" RELATED Gene-based [UniProtKB:Q9Z2J6] synonym: "G-protein coupled receptor 44 (mouse)" EXACT [UniProtKB:Q9Z2J6] synonym: "Gpr44" RELATED Gene-based [UniProtKB:Q9Z2J6] synonym: "mPTGDR2" EXACT PRO-short-label [PRO:DNx] synonym: "Ptgdr2" RELATED Gene-based [UniProtKB:Q9Z2J6] xref: UniProtKB:Q9Z2J6 is_a: PR:000001547 ! prostaglandin D2 receptor DP2 is_a: PR:000029032 ! Mus musculus protein intersection_of: PR:000001547 ! prostaglandin D2 receptor DP2 intersection_of: RO:0002160 NCBITaxon:10090 ! only in taxon Mus musculus [Term] id: RO:0002577 name: system def: "A material entity consisting of multiple components that are causally integrated." [] is_a: BFO:0000040 property_value: IAO:0000116 "May be replaced by a BFO class, as discussed in http://www.jbiomedsem.com/content/4/1/43" xsd:string [Term] id: SO:0001260 name: sequence_collection [Term] id: STATO:0000039 name: statistic def: "a statistic is a measurement datum to describe a dataset or a variable. It is generated by a calculation on set of observed data." [] is_a: IAO:0000027 ! data item relationship: IAO:0000136 IAO:0000100 [Term] id: STATO:0000184 name: ratio def: "A ratio is a data item which is formed with two numbers r and s is written r/s, where r is the numerator and s is the denominator. The ratio of r to s is equivalent to the quotient r/s." [] is_a: STATO:0000039 ! statistic intersection_of: STATO:0000101 IAO:0000027 ! has numerator data item intersection_of: STATO:0000259 IAO:0000027 ! has denominator data item relationship: STATO:0000101 IAO:0000027 ! has numerator data item relationship: STATO:0000259 IAO:0000027 ! has denominator data item property_value: IAO:0000116 "review formal definition as both numerator and denominator should be of the same type, not just some data item" xsd:string [Term] id: STATO:0000416 name: precision def: "precision or positive predictive value is defined as the proportion of the true positives against all the positive results (both true positives and false positives)\n\nA proportion in which the numerator represents the correctly detected items within the denominator that represents all items detected." [] is_a: STATO:0000607 ! proportion [Term] id: STATO:0000607 name: proportion def: "a proportion is a ratio which corresponds to the fraction of the total presenting a particular feature" [] is_a: STATO:0000184 ! ratio [Term] id: STATO:0000610 name: measure of association def: "measure of association is a statistic which quantitatively represents a relationship between two or more variables" [] is_a: STATO:0000039 ! statistic property_value: IAO:0000116 "Expert Working Group Agreement: 2022-03-16 vote 7-0 by Mario Tristan, Paola Rosati, Louis Leff, nisha mathew, Philippe Rocca-Serra, Harold Lehmann, Janice Tufte" xsd:string [Term] id: STATO:0000623 name: measure of agreement def: "A measure of association of two variables representing measurements of the same attribute of an entity." [] is_a: STATO:0000610 ! measure of association property_value: IAO:0000116 "Expert Working Group Agreement: 2022-12-21 vote 5-0 by Mario Tristan, Philippe Rocca-Serra, Eric Harvey, Janice Tuft, Harold Lehmann" xsd:string [Term] id: STATO:0000663 name: F-beta score def: "The F-beta score is a measure of a model's accuracy, specifically designed to evaluate the performance of binary classification models. It is a generalized form of the F1 score, which itself is the harmonic mean of precision and recall. The F-beta score introduces a way to weigh recall more heavily than precision (or vice versa) depending on the value of beta." [] is_a: STATO:0000623 ! measure of agreement property_value: IAO:0000116 "https://github.com/ISA-tools/stato/pull/86" xsd:string [Term] id: UBERON:0000000 name: processual entity def: "An occurrent [span:Occurrent] that exists in time by occurring or happening, has temporal parts and always involves and depends on some entity." [span:ProcessualEntity] comment: This term is being aligned with COB subset: common_anatomy subset: upper_level xref: BFO:0000003 disjoint_from: UBERON:0001062 ! anatomical entity property_value: RO:0002175 NCBITaxon:33090 property_value: RO:0002175 NCBITaxon:33208 property_value: RO:0002175 NCBITaxon:4751 property_value: seeAlso "https://github.com/OBOFoundry/COB/issues/51" xsd:anyURI property_value: skos:prefLabel "processual entity" xsd:string [Term] id: UBERON:0000002 name: uterine cervix def: "Lower, narrow portion of the uterus where it joins with the top end of the vagina." [http://orcid.org/0000-0002-6601-2165, Wikipedia:Cervix] subset: efo_slim subset: human_reference_atlas subset: pheno_slim subset: uberon_slim synonym: "canalis cervicis uteri" EXACT OMO:0003011 [FMA:17740, FMA:TA] synonym: "caudal segment of uterus" EXACT [] synonym: "cervical canal" RELATED [FMA:17740] synonym: "cervical canal of uterus" EXACT [FMA:17740] synonym: "cervix" BROAD [EFO:0000979] synonym: "cervix of uterus" RELATED [BTO:0001421] synonym: "cervix uteri" EXACT OMO:0003011 [EMAPA:29927] synonym: "neck of uterus" EXACT [FMA:17740] synonym: "uterine cervix" EXACT [FMA:17740] xref: BTO:0001421 xref: BTO:0002249 xref: CALOHA:TS-0134 xref: EFO:0000979 xref: EMAPA:29927 xref: EV:0100114 xref: FMA:17740 xref: GAID:376 xref: galen:CervixUteri xref: MA:0000392 xref: MAT:0000292 xref: MESH:D002584 xref: NCIT:C12311 xref: SCTID:181453009 xref: UMLS:C0007874 {source="ncithesaurus:Cervix"} xref: VHOG:0001359 xref: Wikipedia:Cervix is_a: UBERON:0001560 ! neck of organ is_a: UBERON:0005156 ! reproductive structure intersection_of: UBERON:0001560 ! neck of organ intersection_of: BFO:0000050 UBERON:0000995 ! part of uterus intersection_of: RO:0002150 UBERON:0000996 ! continuous with vagina relationship: BFO:0000050 UBERON:0000995 ! part of uterus relationship: RO:0002150 UBERON:0000996 ! continuous with vagina relationship: RO:0002433 UBERON:0000995 ! contributes to morphology of uterus property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/uterus-female/v1.2/assets/3d-vh-f-uterus.glb" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0000003 name: naris def: "Orifice of the olfactory system. The naris is the route by which odorants enter the olfactory system[MAH]." [http://orcid.org/0000-0001-9114-8737] subset: uberon_slim subset: vertebrate_core xref: AAO:0000311 xref: EHDAA2:0001225 xref: EHDAA:9083 xref: EMAPA:17847 xref: galen:Naris xref: MA:0000282 xref: SCTID:272650008 xref: VHOG:0000663 is_a: UBERON:0000161 ! orifice intersection_of: UBERON:0000161 ! orifice intersection_of: BFO:0000050 UBERON:0005725 ! part of olfactory system intersection_of: RO:0002176 UBERON:0001707 ! connects nasal cavity relationship: BFO:0000050 UBERON:0000033 {source="ZFA"} ! part of head relationship: BFO:0000050 UBERON:0005725 ! part of olfactory system relationship: RO:0002176 UBERON:0001707 ! connects nasal cavity [Term] id: UBERON:0000004 name: nose def: "The olfactory organ of vertebrates, consisting of nares, olfactory epithelia and the structures and skeletal framework of the nasal cavity." [UBERON:cjm] subset: efo_slim subset: major_organ subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "nasal sac" EXACT SENSU [ZFA:0000047] synonym: "nasus" RELATED OMO:0003011 [Wikipedia:Nose] synonym: "nose" EXACT HUMAN_PREFERRED [MA:0000281] synonym: "olfactory apparatus" RELATED [UBERON:cjm] synonym: "peripheral olfactory organ" EXACT [ZFA:0000047] synonym: "proboscis" RELATED [] xref: BTO:0000840 xref: CALOHA:TS-2037 xref: EHDAA2:0001274 xref: EHDAA:1502 xref: EMAPA:16542 xref: EV:0100037 xref: EV:0100370 xref: FMA:46472 xref: GAID:77 xref: galen:Nose xref: MA:0000281 xref: MAT:0000139 xref: MESH:D009666 xref: MIAA:0000139 xref: NCIT:C12756 xref: SCTID:181195007 xref: TAO:0000047 xref: UMLS:C0028429 {source="ncithesaurus:Nose"} xref: Wikipedia:Nose xref: ZFA:0000047 is_a: UBERON:0002268 ! olfactory organ is_a: UBERON:0004121 ! ectoderm-derived structure relationship: BFO:0000050 UBERON:0001456 {source="FMA", source="ZFA-def"} ! part of face relationship: RO:0002202 UBERON:0003050 {source="ZFA"} ! develops from olfactory placode relationship: RO:0002216 GO:0007608 ! capable of part of sensory perception of smell relationship: RO:0002433 UBERON:0001004 ! contributes to morphology of respiratory system relationship: RO:0002433 UBERON:0001456 ! contributes to morphology of face relationship: RO:0002551 UBERON:0006813 ! has skeleton nasal skeleton property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/d/d0/Canine-nose.jpg" xsd:anyURI property_value: skos:prefLabel "nose" xsd:string [Term] id: UBERON:0000005 name: chemosensory organ subset: functional_classification subset: uberon_slim synonym: "chemosensory sensory organ" EXACT [FBbt:00005157] xref: FBbt:00005157 {sssom:mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"} is_a: UBERON:0000020 ! sense organ intersection_of: UBERON:0000020 ! sense organ intersection_of: RO:0002215 GO:0007606 ! capable of sensory perception of chemical stimulus relationship: BFO:0000050 UBERON:0001016 ! part of nervous system relationship: BFO:0000050 UBERON:0005726 ! part of chemosensory system relationship: RO:0002215 GO:0007606 ! capable of sensory perception of chemical stimulus property_value: skos:prefLabel "chemosensory organ" xsd:string [Term] id: UBERON:0000006 name: islet of Langerhans def: "The clusters of hormone-producing cells that are scattered throughout the pancreas." [MA:0000127, MESH:A03.734.414, MP:0005215] subset: efo_slim subset: human_reference_atlas subset: pheno_slim subset: uberon_slim synonym: "island of Langerhans" RELATED [BTO:0000991] synonym: "island of pancreas" RELATED [BTO:0000991] synonym: "islets of Langerhans" RELATED [] synonym: "pancreatic insula" EXACT [] synonym: "pancreatic islet" EXACT [] xref: AAO:0010406 xref: BTO:0000991 xref: CALOHA:TS-0741 xref: EFO:0000856 xref: EMAPA:32927 xref: EV:0100130 xref: FMA:16016 xref: GAID:324 xref: MA:0000127 xref: MAT:0000076 xref: MESH:D007515 xref: MIAA:0000076 xref: NCIT:C12608 xref: UMLS:C0022131 {source="ncithesaurus:Islet_of_Langerhans"} xref: VHOG:0000646 xref: Wikipedia:Islets_of_Langerhans xref: XAO:0000159 is_a: UBERON:0034922 ! cell cluster relationship: BFO:0000050 UBERON:0000016 ! part of endocrine pancreas relationship: BFO:0000051 CL:0000168 {source="PMID:16417468"} ! has part insulin secreting cell relationship: BFO:0000051 CL:0000172 {source="PMID:16417468"} ! has part somatostatin secreting cell relationship: BFO:0000051 CL:0002067 {source="PMID:16417468"} ! has part type A enteroendocrine cell relationship: RO:0002433 UBERON:0000016 ! contributes to morphology of endocrine pancreas property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/9/99/Gray1105.png" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "islet of Langerhans" xsd:string [Term] id: UBERON:0000007 name: pituitary gland def: "The pituitary gland is an endocrine gland that secretes hormones that regulate many other glands [GO]. An endocrine gland located ventral to the diencephalon and derived from mixed neuroectodermal and non neuroectodermal origin [ZFIN]." [Wikipedia:Pituitary_gland, ZFIN:curator] comment: Terminology note: hypophysis and pituitary gland are often used informally as synonyms, but the hypophysis also includes the small infundibular or pituitary stalk[Neumann 2020] subset: efo_slim subset: organ_slim subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "glandula pituitaria" EXACT OMO:0003011 [Wikipedia:Pituitary_gland] synonym: "Hp" BROAD OMO:0003000 [BIRNLEX:1353, NIFSTD:NeuroNames_abbrevSource] synonym: "hypophysis" RELATED [ZFA:0000118] synonym: "hypophysis cerebri" RELATED [MA:0000176] synonym: "pituitary" EXACT [BTO:0001073] synonym: "pituitary body" EXACT [BTO:0001073] xref: AAO:0010536 xref: BAMS:PIT xref: BAMS:Pit xref: BIRNLEX:1353 xref: BM:Die-Hy-HY xref: BTO:0001073 xref: CALOHA:TS-0798 xref: DHBA:10505 xref: EFO:0000857 xref: EHDAA2:0001471 xref: EHDAA:2183 xref: EHDAA:4477 xref: EMAPA:35998 xref: EV:0100132 xref: FMA:13889 xref: GAID:457 xref: HBA:4634 xref: MA:0000176 xref: MAT:0000077 xref: MESH:D010902 xref: MIAA:0000077 xref: NCIT:C12399 xref: neuronames:399 {source="BIRNLEX:1353"} xref: SCTID:181125003 xref: TAO:0000118 xref: UMLS:C0032005 {source="ncithesaurus:Pituitary_Gland", source="BIRNLEX:1353"} xref: VHOG:0000143 xref: Wikipedia:Pituitary_gland xref: XAO:0000017 xref: ZFA:0000118 is_a: UBERON:0002368 {source="BTO", source="EFO", source="VHOG"} ! endocrine gland is_a: UBERON:0003133 ! reproductive organ is_a: UBERON:0003296 ! gland of diencephalon is_a: UBERON:0003937 ! reproductive gland is_a: UBERON:0004121 ! ectoderm-derived structure relationship: BFO:0000051 CL:0000440 {source="ZFA"} ! has part melanocyte stimulating hormone secreting cell relationship: BFO:0000051 CL:0000642 {source="ZFA"} ! has part folliculostellate cell relationship: BFO:0000051 UBERON:0002196 ! has part adenohypophysis relationship: BFO:0000051 UBERON:0002198 ! has part neurohypophysis relationship: RO:0002216 GO:0007276 ! capable of part of gamete generation relationship: RO:0002433 UBERON:0001894 ! contributes to morphology of diencephalon relationship: RO:0002495 UBERON:0034875 {source="https://orcid.org/0000-0003-3308-6245"} ! immediate transformation of future pituitary gland property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/9/97/Gray1180.png" xsd:anyURI property_value: skos:prefLabel "pituitary gland" xsd:string [Term] id: UBERON:0000009 name: submucosa def: "A layer of dense irregular connective tissue that lines organs and supports the mucosa, as well as joins the mucosa to the bulk of underlying smooth muscle. [WP,unvetted]." [Wikipedia:Submucosa] subset: pheno_slim subset: uberon_slim synonym: "organ submucosa" EXACT [FMA:85391] synonym: "region of submucosa" EXACT [FMA:85392] synonym: "submucosa of organ" EXACT [FMA:85391] synonym: "submucosa of region of organ" EXACT [FMA:85392] synonym: "submucous layer" RELATED [BTO:0002107] synonym: "tela submucosa" RELATED [BTO:0002107] synonym: "tunica submucosa" RELATED [] xref: BTO:0002107 xref: FMA:85391 xref: FMA:85392 xref: NCIT:C13167 xref: SCTID:68439008 xref: UMLS:C0225344 {source="ncithesaurus:Submucosa"} xref: Wikipedia:Submucosa is_a: UBERON:0004923 ! organ component layer relationship: BSPO:0001107 UBERON:0000344 ! mucosa relationship: RO:0002162 NCBITaxon:7711 ! in taxon Chordata relationship: RO:0002473 UBERON:0002384 ! composed primarily of connective tissue property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/4/4e/Ens.png" xsd:anyURI property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/en/thumb/4/4e/Ens.png/200px-Ens.png" xsd:anyURI property_value: skos:prefLabel "submucosa" xsd:string [Term] id: UBERON:0000010 name: peripheral nervous system def: "A major division of the nervous system that contains nerves which connect the central nervous system (CNS) with sensory organs, other organs, muscles, blood vessels and glands." [GO:0007422] subset: cumbo subset: efo_slim subset: human_reference_atlas subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "pars peripherica" EXACT OMO:0003011 [FMA:9903, FMA:TA, Wikipedia:Peripheral_nervous_system] synonym: "PNS" BROAD OMO:0003000 [] synonym: "systema nervosum periphericum" EXACT OMO:0003011 [FMA:9903, FMA:TA, Wikipedia:Peripheral_nervous_system] xref: AAO:0000429 xref: BAMS:PNS xref: BILA:0000081 xref: BIRNLEX:1111 xref: BTO:0001028 xref: CALOHA:TS-0808 xref: EFO:0000891 xref: EHDAA2:0001445 xref: EHDAA:2893 xref: EMAPA:16665 xref: EV:0100335 xref: FBbt:00005098 {sssom:mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"} xref: FMA:9903 xref: GAID:715 xref: MA:0000218 xref: MAT:0000338 xref: MESH:D017933 xref: MIAA:0000338 xref: NCIT:C12465 xref: neuronames:3232 xref: SCTID:362292005 xref: TAO:0000142 xref: UMLS:C0206417 {source="ncithesaurus:Peripheral_Nervous_System", source="BIRNLEX:1111"} xref: UMLS:C1305921 {source="BIRNLEX:1111"} xref: VHOG:0000399 xref: Wikipedia:Peripheral_nervous_system xref: XAO:0000178 xref: ZFA:0000142 is_a: UBERON:0011216 {source="cjm"} ! organ system subdivision relationship: BFO:0000050 UBERON:0001016 ! part of nervous system property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/b/ba/Nervous_system_diagram.png" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "peripheral nervous system" xsd:string [Term] id: UBERON:0000011 name: parasympathetic nervous system def: "The parasympathetic nervous system is one of the two divisions of the vertebrate autonomic nervous system. Parasympathetic nerves emerge cranially as pre ganglionic fibers from oculomotor, facial, glossopharyngeal and vagus and from the sacral region of the spinal cord. Most neurons are cholinergic and responses are mediated by muscarinic receptors. The parasympathetic system innervates, for example: salivary glands, thoracic and abdominal viscera, bladder and genitalia[GO]." [GO:0048486] subset: efo_slim subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "parasympathetic part of autonomic division of nervous system" EXACT [] synonym: "pars parasympathica divisionis autonomici systematis nervosi" EXACT OMO:0003011 [FMA:9907, FMA:TA] synonym: "pars parasympathica divisionis autonomici systematis nervosi" RELATED OMO:0003011 [Wikipedia:Parasympathetic_nervous_system] synonym: "PNS - parasympathetic" EXACT [] xref: AAO:0010488 xref: BIRNLEX:2517 xref: BTO:0001833 xref: CALOHA:TS-2094 xref: EFO:0000894 xref: EHDA:10096 xref: EHDAA2:0001402 xref: EHDAA:4655 xref: EMAPA:17270 xref: FMA:9907 xref: GAID:708 xref: MA:0000223 xref: MAT:0000101 xref: MESH:D010275 xref: MIAA:0000101 xref: NCIT:C12764 xref: SCTID:362496006 xref: TAO:0001575 xref: UMLS:C0030510 {source="BIRNLEX:2517", source="ncithesaurus:Parasympathetic_Nervous_System"} xref: UMLS:C1305770 {source="BIRNLEX:2517"} xref: VHOG:0000755 xref: Wikipedia:Parasympathetic_nervous_system xref: ZFA:0001575 is_a: UBERON:0010314 ! structure with developmental contribution from neural crest is_a: UBERON:0011216 {source="cjm"} ! organ system subdivision relationship: BFO:0000050 UBERON:0002410 {source="FMA", source="MA", source="WP", source="ZFA-modified-from-isa"} ! part of autonomic nervous system relationship: RO:0002433 UBERON:0002410 ! contributes to morphology of autonomic nervous system property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/f/f7/Gray839.png" xsd:anyURI property_value: skos:prefLabel "parasympathetic nervous system" xsd:string [Term] id: UBERON:0000012 name: somatic nervous system def: "Part of peripheral nervous system that includes the somatic parts of the cranial and spinal nerves and their ganglia and the peripheral sensory receptors." [NLXANAT:100301] subset: pheno_slim subset: uberon_slim synonym: "PNS - somatic" EXACT [] synonym: "somatic nervous system, somatic division" EXACT [NLXANAT:100301] synonym: "somatic part of peripheral nervous system" EXACT [UBERON:cjm] synonym: "somatic peripheral nervous system" EXACT [NLXANAT:100301] xref: EFO:0000892 xref: FMA:9904 xref: MA:0002850 xref: MAT:0000099 xref: MIAA:0000099 xref: NLXANAT:100301 xref: Wikipedia:Somatic_nervous_system is_a: UBERON:0011216 {source="cjm"} ! organ system subdivision relationship: BFO:0000050 UBERON:0000010 ! part of peripheral nervous system relationship: RO:0002433 UBERON:0001016 ! contributes to morphology of nervous system property_value: skos:prefLabel "somatic nervous system" xsd:string [Term] id: UBERON:0000013 name: sympathetic nervous system def: "The sympathetic nervous system is one of the two divisions of the vertebrate autonomic nervous system (the other being the parasympathetic nervous system). The sympathetic preganglionic neurons have their cell bodies in the thoracic and lumbar regions of the spinal cord and connect to the paravertebral chain of sympathetic ganglia. Innervate heart and blood vessels, sweat glands, viscera and the adrenal medulla. Most sympathetic neurons, but not all, use noradrenaline as a post-ganglionic neurotransmitter [GO]." [GO:0048485] subset: efo_slim subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "pars sympathica divisionis autonomici systematis nervosi" EXACT OMO:0003011 [FMA:9906, FMA:TA] synonym: "pars sympathica divisionis autonomici systematis nervosi" RELATED OMO:0003011 [Wikipedia:Sympathetic_nervous_system] synonym: "sympathetic nervous system" EXACT [] synonym: "sympathetic part of autonomic division of nervous system" EXACT [] xref: AAO:0010487 xref: BIRNLEX:2516 xref: BTO:0001832 xref: CALOHA:TS-2050 xref: EFO:0000893 xref: EHDAA2:0001971 xref: EHDAA:3769 xref: EMAPA:16985 xref: FMA:9906 xref: GAID:710 xref: MA:0000225 xref: MESH:D013564 xref: MIAA:0000100 xref: NCIT:C12795 xref: SCTID:362484004 xref: TAO:0001576 xref: UMLS:C0039044 {source="BIRNLEX:2516", source="ncithesaurus:Sympathetic_Nervous_System"} xref: UMLS:C1269646 {source="BIRNLEX:2516"} xref: VHOG:0000384 xref: Wikipedia:Sympathetic_nervous_system xref: ZFA:0001576 is_a: UBERON:0011216 {source="cjm"} ! organ system subdivision relationship: BFO:0000050 UBERON:0002410 {source="FMA", source="MA", source="ZFA-modified-from-isa"} ! part of autonomic nervous system relationship: RO:0002433 UBERON:0002410 ! contributes to morphology of autonomic nervous system property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/7/77/Gray838.png" xsd:anyURI property_value: skos:prefLabel "sympathetic nervous system" xsd:string [Term] id: UBERON:0000014 name: zone of skin def: "Any portion of the organ that covers that body and consists of a layer of epidermis and a layer of dermis." [http://orcid.org/0000-0002-6601-2165, Wikipedia:Skin] subset: pheno_slim synonym: "portion of skin" EXACT [] synonym: "region of skin" EXACT [] synonym: "skin" EXACT [MA:0000151] synonym: "skin region" EXACT [] synonym: "skin zone" EXACT [] xref: EHDAA:6530 xref: EV:0100152 xref: FMA:86166 xref: GAID:933 xref: MA:0000151 xref: MAT:0000284 xref: MESH:D012867 xref: MIAA:0000284 xref: SCTID:20795001 xref: VHOG:0000860 xref: Wikipedia:Skin is_a: UBERON:0010314 ! structure with developmental contribution from neural crest is_a: UBERON:0034944 {source="FMA"} ! zone of organ relationship: BFO:0000050 UBERON:0002097 ! part of skin of body relationship: BFO:0000051 UBERON:0001003 ! has part skin epidermis relationship: BFO:0000051 UBERON:0002067 ! has part dermis property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/6/6d/Skin.svg" xsd:anyURI property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/e/e8/HumanSkinDiagram.jpg" xsd:anyURI property_value: skos:prefLabel "zone of skin" xsd:string [Term] id: UBERON:0000015 name: non-material anatomical boundary def: "A non-material anatomical entity of two dimensions. Anatomical boundaries are contiguous structures." [CARO:0000010] comment: Except in the case of abstracted fiat boundaries such as the midline plane of an organism, all 2D anatomical entities have a 3 dimensional projection. For example, the surface of the shell of a muscle has a distinct shape that projects into the third dimension. Note that boundaries are 2D structures. They have no thickness - and so can not be sites of gene expression or gene product localisation. For this, use boundary region terms. subset: common_anatomy subset: upper_level synonym: "anatomical boundary" EXACT [CARO:0000010] xref: AEO:0000192 xref: CARO:0000010 xref: FMA:50705 is_a: UBERON:0000466 {source="CARO"} ! immaterial anatomical entity property_value: RO:0002175 NCBITaxon:33090 property_value: RO:0002175 NCBITaxon:33208 property_value: RO:0002175 NCBITaxon:4751 property_value: skos:prefLabel "non-material anatomical boundary" xsd:string [Term] id: UBERON:0000016 name: endocrine pancreas def: "The part of the pancreas that is part of the endocrine system and is made up of islet cells, which produce insulin, glucagon and somatostatin." [GO:GO, http://orcid.org/0000-0002-6601-2165] subset: efo_slim subset: human_reference_atlas subset: organ_slim subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "endocrine pancreas" EXACT [] synonym: "endocrine part of pancreas" RELATED [BTO:0000650] synonym: "islets of Langerhans part of pancreas" RELATED [] synonym: "pars endocrina pancreatis" EXACT [] xref: BTO:0000650 xref: CALOHA:TS-1302 xref: EFO:0002542 xref: EMAPA:35305 xref: EV:0100129 xref: FMA:16018 xref: MA:0001582 xref: MESH:D007515 {sssom:mapping_justification="https://w3id.org/semapv/vocab/LexicalMatching"} xref: NCIT:C32509 xref: SCTID:361339003 xref: TAO:0001260 xref: VHOG:0000049 xref: Wikipedia:Islets_of_Langerhans xref: ZFA:0001260 is_a: UBERON:0000471 {source="ZFA"} ! compound organ component is_a: UBERON:0004119 ! endoderm-derived structure relationship: BFO:0000050 UBERON:0000949 {source="AAO", source="FMA", source="XAO"} ! part of endocrine system relationship: BFO:0000050 UBERON:0001264 ! part of pancreas relationship: RO:0002202 UBERON:0003923 ! develops from dorsal pancreatic bud relationship: RO:0002215 GO:0030073 {source="GO"} ! capable of insulin secretion relationship: RO:0002215 GO:0070091 {source="GO"} ! capable of glucagon secretion relationship: RO:0002215 GO:0070253 {source="GO"} ! capable of somatostatin secretion relationship: RO:0002433 UBERON:0001264 ! contributes to morphology of pancreas relationship: RO:0002473 UBERON:0000006 ! composed primarily of islet of Langerhans property_value: IAO:0000116 "create a separate class for distributed pancreas, eg cyclostomes?" xsd:string property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "endocrine pancreas" xsd:string [Term] id: UBERON:0000017 name: exocrine pancreas def: "The part of the pancreas that is part of the exocrine system and which produces and store zymogens of digestive enzymes, such as chymotrypsinogen and trypsinogen in the acinar cells [GO]." [GOC:GO, http://orcid.org/0000-0002-6601-2165] subset: human_reference_atlas subset: organ_slim subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "exocrine component of pancreas" RELATED [] synonym: "exocrine pancreas" EXACT [] synonym: "exocrine part of pancreas" RELATED [BTO:0000434] synonym: "pars exocrina pancreatis" EXACT [] xref: AAO:0010407 xref: BTO:0000434 xref: CALOHA:TS-1241 xref: EMAPA:35328 xref: EV:0100093 xref: FMA:16017 xref: MA:0002415 xref: NCIT:C32546 xref: SCTID:248202004 xref: TAO:0001249 xref: UMLS:C0553695 {source="ncithesaurus:Exocrine_Pancreas"} xref: VHOG:0000048 xref: Wikipedia:Exocrine_component_of_pancreas xref: XAO:0000137 xref: ZFA:0001249 is_a: UBERON:0000409 ! serous gland is_a: UBERON:0004119 ! endoderm-derived structure is_a: UBERON:0005177 ! trunk region element is_a: UBERON:0013765 ! digestive system element relationship: BFO:0000050 UBERON:0001264 ! part of pancreas relationship: BFO:0000051 UBERON:0001263 ! has part pancreatic acinus relationship: BFO:0000051 UBERON:0007329 ! has part pancreatic duct relationship: RO:0002202 UBERON:0003924 ! develops from ventral pancreatic bud relationship: RO:0002216 GO:0007586 ! capable of part of digestion relationship: RO:0002433 UBERON:0001264 ! contributes to morphology of pancreas property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "exocrine pancreas" xsd:string [Term] id: UBERON:0000018 name: compound eye def: "A light sensing organ composed of ommatidia." [FB:gg, Wikipedia:Compound_eye] subset: organ_slim subset: uberon_slim synonym: "adult compound eye" RELATED [] synonym: "faceted eye" RELATED [] synonym: "Facettenauge" RELATED [BTO:0001921] synonym: "insect eye" RELATED [] synonym: "Komplexauge" RELATED [BTO:0001921] synonym: "zusammengesetztes Auge" RELATED [BTO:0001921] xref: BTO:0001921 xref: FBbt:00004508 {sssom:mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"} xref: HAO:0000217 xref: TGMA:0000024 xref: Wikipedia:Compound_eye is_a: UBERON:0015165 ! multi-unit eye intersection_of: UBERON:0000970 ! eye intersection_of: RO:0002473 UBERON:0000971 ! composed primarily of ommatidium relationship: RO:0002473 UBERON:0000971 ! composed primarily of ommatidium property_value: seeAlso "https://github.com/obophenotype/uberon/issues/457" xsd:anyURI [Term] id: UBERON:0000019 name: camera-type eye def: "An organ of sight that includes the camera-type eyeball and supporting structures such as the lacrimal apparatus, the conjunctiva, the eyelid." [GO:0043010, https://orcid.org/0000-0002-6601-2165] subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "camera-type eye plus associated structures" RELATED [] synonym: "eye" BROAD [FMA:54448] synonym: "eyes" RELATED OMO:0003004 [TAO:0000107] synonym: "orbital part of face" RELATED [FMA:54448] synonym: "orbital region" RELATED [FMA:54448] synonym: "regio orbitalis" EXACT OMO:0003011 [FMA:54448, FMA:TA] synonym: "vertebrate eye" NARROW [] xref: AAO:0010340 xref: BIRNLEX:1169 xref: BTO:0004688 xref: EHDAA2:0000484 xref: EHDAA:936 xref: EMAPA:16198 xref: FMA:54448 xref: MA:0000261 xref: NCIT:C12401 xref: SCTID:181143004 xref: TAO:0000107 xref: UMLS:C0015392 {source="BIRNLEX:1169", source="ncithesaurus:Eye"} xref: UMLS:C1280202 {source="BIRNLEX:1169"} xref: VHOG:0000275 xref: XAO:0000179 xref: ZFA:0000107 is_a: UBERON:0000047 ! simple eye is_a: UBERON:0004121 ! ectoderm-derived structure is_a: UBERON:0010314 ! structure with developmental contribution from neural crest is_a: UBERON:0015212 ! lateral structure relationship: BFO:0000050 UBERON:0004088 ! part of orbital region relationship: BFO:0000051 UBERON:0000965 ! has part lens of camera-type eye relationship: BFO:0000051 UBERON:0000966 ! has part retina relationship: BSPO:0000126 UBERON:0000033 ! head relationship: RO:0002202 UBERON:0003072 {evidence="definitional"} ! develops from optic cup relationship: RO:0002492 UBERON:0000066 ! existence ends during fully formed stage property_value: skos:prefLabel "camera-type eye" xsd:string [Term] id: UBERON:0000020 name: sense organ def: "An organ that is capable of transducing sensory stimulus to the nervous system." [https://github.com/obophenotype/uberon/issues/549, https://orcid.org/0000-0002-6601-2165] subset: uberon_slim synonym: "organ of sense organ system" EXACT [OBOL:accepted] synonym: "organ of sensory organ system" EXACT [OBOL:accepted] synonym: "organ of sensory system" EXACT [OBOL:accepted] synonym: "sense organ system organ" EXACT [OBOL:automatic] synonym: "sensillum" NARROW [WBbt:0006929] synonym: "sensor" RELATED [] synonym: "sensory organ" EXACT [] synonym: "sensory organ system organ" EXACT [OBOL:automatic] synonym: "sensory system organ" EXACT [OBOL:accepted] synonym: "Sinnesorgan" RELATED [BTO:0000202] xref: AEO:0000094 xref: BSA:0000121 xref: BTO:0000202 xref: CALOHA:TS-2043 xref: EHDAA2:0001824 xref: EHDAA:500 xref: EMAPA:35955 xref: FBbt:00005155 {sssom:mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"} xref: GAID:63 xref: HAO:0000930 xref: MA:0000017 xref: MESH:D012679 xref: NCIT:C33224 xref: SCTID:244485009 xref: UMLS:C0935626 {source="ncithesaurus:Organ_of_the_Special_Sense"} xref: VHOG:0001407 xref: WBbt:0006929 is_a: UBERON:0000062 ! organ intersection_of: UBERON:0000062 ! organ intersection_of: RO:0002215 GO:0050906 ! capable of detection of stimulus involved in sensory perception relationship: BFO:0000050 UBERON:0001032 ! part of sensory system relationship: RO:0002215 GO:0050906 ! capable of detection of stimulus involved in sensory perception property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/c/c0/Gray722.png" xsd:anyURI property_value: skos:prefLabel "sense organ" xsd:string property_value: terms:contributor https://orcid.org/0000-0002-6601-2165 [Term] id: UBERON:0000021 name: cutaneous appendage def: "Anatomical projection that protrudes from the skin. Examples: hair, nail, feather, claw, hoof, horn, wattle, spur, beak, antler, bristle and some scales." [https://orcid.org/0000-0002-6601-2165] subset: uberon_slim synonym: "epidermal appendage" NARROW [] synonym: "epidermal growth" RELATED [] synonym: "skin appendage" EXACT [FMA:71012] xref: CALOHA:TS-0051 xref: FMA:71012 xref: SCTID:276160000 is_a: UBERON:0013703 ! integumentary projection relationship: RO:0002371 UBERON:0002097 ! attached to skin of body property_value: IAO:0000116 "Mammary glands develop by similar mechanisms, and there is an argument for including them here (e.g. http://www.ncbi.nlm.nih.gov/pubmed/20484386), but these structures do not fit the current definition (lactiferous glands are part of the integumentary system in FMA). Note the FMA class is a subdivision of epidermis, which may be too restrictive for our purposes here." xsd:string [Term] id: UBERON:0000025 name: tube def: "Any hollow cylindrical anatomical structure containing a lumen through which substances are transported." [http://orcid.org/0000-0002-6601-2165] synonym: "anatomical tube" EXACT [] synonym: "duct" NARROW [] xref: galen:Tube is_a: UBERON:0004111 ! anatomical conduit intersection_of: UBERON:0004111 ! anatomical conduit intersection_of: RO:0000086 PATO:0002299 ! has quality tubular relationship: BFO:0000051 UBERON:0013522 ! has part subdivision of tube relationship: RO:0000086 PATO:0002299 ! has quality tubular property_value: skos:prefLabel "tube" xsd:string [Term] id: UBERON:0000026 name: appendage def: "Major subdivision of an organism that protrudes from the body[DOS, CARO]." [CARO:DOS] subset: efo_slim subset: pheno_slim subset: uberon_slim synonym: "appendages" RELATED OMO:0003004 [XAO:0000218] synonym: "extremitaet" RELATED [BTO:0001492] synonym: "extremity" RELATED [] synonym: "limbs/digits/tail" RELATED [MP:0000001] xref: AEO:0000193 xref: BILA:0000018 xref: BTO:0001492 xref: CARO:0010003 xref: EFO:0000799 xref: EHDAA2:0003193 xref: EMAPA:37283 {source="MA:th"} xref: EV:0100155 xref: FBbt:00007000 {sssom:mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"} xref: HAO:0000144 xref: MAT:0000023 xref: MESH:D005121 xref: MIAA:0000023 xref: NCIT:C61460 xref: UMLS:C0598782 {source="ncithesaurus:Appendage"} xref: VSAO:0000075 xref: Wikipedia:Appendage xref: XAO:0000218 is_a: UBERON:0000475 ! organism subdivision relationship: RO:0002162 NCBITaxon:6072 ! in taxon Eumetazoa property_value: skos:prefLabel "appendage" xsd:string [Term] id: UBERON:0000029 name: lymph node def: "Any of the rounded masses of lymphoid tissue that are surrounded by a capsule of connective tissue, are distributed along the lymphatic vessels, and contain numerous lymphocytes which filter the flow of lymph." [BTO:0000784] subset: efo_slim subset: human_reference_atlas subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "lymph gland" RELATED [VHOG:0001273] synonym: "nodus lymphaticus" RELATED OMO:0003011 [Wikipedia:Lymph_node] xref: BTO:0000784 xref: CALOHA:TS-0579 xref: EFO:0000872 xref: EMAPA:35523 xref: EV:0100050 xref: FMA:5034 xref: GAID:947 xref: galen:Lymphnode xref: MA:0000139 xref: MAT:0000442 xref: MESH:D008198 xref: NCIT:C12745 xref: NCIT:C33027 xref: SCTID:181756000 xref: TAO_RETIRED:0005318 xref: UMLS:C0024204 {source="ncithesaurus:Lymph_Node"} xref: VHOG:0001273 xref: Wikipedia:Lymph_node xref: ZFA_RETIRED:0005318 is_a: BFO:0000002 is_a: UBERON:0005057 ! immune organ intersection_of: UBERON:0000062 ! organ intersection_of: RO:0002150 UBERON:0001473 ! continuous with lymphatic vessel intersection_of: RO:0002473 UBERON:0001744 ! composed primarily of lymphoid tissue relationship: BFO:0000050 UBERON:0002465 ! part of lymphoid system relationship: BFO:0000051 UBERON:0002006 ! has part cortex of lymph node relationship: BFO:0000051 UBERON:0002007 ! has part medulla of lymph node relationship: BFO:0000051 UBERON:0002194 ! has part capsule of lymph node relationship: BFO:0000051 UBERON:0002391 ! has part lymph relationship: RO:0002150 UBERON:0001473 ! continuous with lymphatic vessel relationship: RO:0002202 UBERON:0034953 ! develops from embryonic lymph sac relationship: RO:0002473 UBERON:0001744 ! composed primarily of lymphoid tissue property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/b/b8/Illu_lymph_node_structure.png" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 property_value: seeAlso "https://github.com/obophenotype/uberon/issues/650" xsd:anyURI [Term] id: UBERON:0000030 name: lamina propria def: "A thin layer of loose connective tissue which lies beneath the epithelium and together with the epithelium constitutes the mucosa[WP]. The lamina propria contains capillaries and a central lacteal (lymph vessel) in the small intestine, as well as lymphoid tissue. Lamina propria also contains glands with the ducts opening on to the mucosal epithelium, that secrete mucus and serous secretions." [Wikipedia:Lamina_propria] subset: uberon_slim synonym: "lamina propria mucosa" EXACT [] synonym: "lamina propria mucosae" EXACT [] synonym: "tunica propria" RELATED [BTO:0002330] xref: BTO:0002330 xref: FMA:62517 xref: NCIT:C32918 xref: SCTID:298225002 xref: UMLS:C1179187 {source="ncithesaurus:Lamina_Propria"} xref: Wikipedia:Lamina_propria is_a: UBERON:0004923 ! organ component layer relationship: BFO:0000050 UBERON:0000344 ! part of mucosa relationship: BSPO:0001107 UBERON:0000483 ! epithelium relationship: RO:0002473 UBERON:0011825 ! composed primarily of loose connective tissue property_value: foaf:depiction "https://upload.wikimedia.org/wikipedia/commons/f/fb/GI_Organization.svg" xsd:anyURI property_value: skos:prefLabel "lamina propria" xsd:string [Term] id: UBERON:0000031 name: lamina propria of trachea def: "A lamina propria that is part of a respiratory airway." [OBOL:automatic] synonym: "lamina propria mucosa of trachea" EXACT [OBOL:automatic] synonym: "lamina propria mucosa of windpipe" EXACT [OBOL:automatic] synonym: "lamina propria mucosae of trachea" EXACT [OBOL:automatic] synonym: "lamina propria mucosae of windpipe" EXACT [OBOL:automatic] synonym: "lamina propria of windpipe" EXACT [OBOL:automatic] synonym: "trachea lamina propria" EXACT [] synonym: "trachea lamina propria mucosa" EXACT [OBOL:automatic] synonym: "trachea lamina propria mucosae" EXACT [OBOL:automatic] synonym: "tracheal lamina propria" EXACT [] synonym: "windpipe lamina propria" EXACT [OBOL:automatic] synonym: "windpipe lamina propria mucosa" EXACT [OBOL:automatic] synonym: "windpipe lamina propria mucosae" EXACT [OBOL:automatic] xref: EMAPA:35877 xref: FMA:265157 xref: MA:0001858 xref: NCIT:C49305 xref: UMLS:C1710457 {source="ncithesaurus:Trachea_Lamina_Propria"} is_a: UBERON:0004779 ! respiratory system lamina propria intersection_of: UBERON:0000030 ! lamina propria intersection_of: BFO:0000050 UBERON:0001005 ! part of respiratory airway relationship: BFO:0000050 UBERON:0000379 {is_inferred="true", source="https://github.com/obophenotype/uberon/wiki/Inferring-part-of-relationships"} ! part of tracheal mucosa property_value: skos:prefLabel "lamina propria of trachea" xsd:string [Term] id: UBERON:0000033 name: head def: "The head is the anterior-most division of the body [GO]." [GO:0060322, Wikipedia:Head] subset: efo_slim subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "adult head" NARROW [] synonym: "cephalic area" RELATED [SPD:0000016] synonym: "head (volume)" EXACT [FMA:7154] xref: AAO:0010335 xref: AEO:0000106 xref: BILA:0000115 xref: BIRNLEX:1230 xref: BTO:0000282 xref: CALOHA:TS-0436 xref: EFO:0000964 xref: EHDAA2:0003106 xref: EMAPA:31858 xref: FMA:7154 xref: GAID:61 xref: galen:Head xref: HAO:0000397 xref: MA:0000023 xref: MAT:0000294 xref: MESH:D006257 xref: MIAA:0000294 xref: NCIT:C12419 xref: SCTID:302548004 xref: SPD:0000016 xref: TAO:0001114 xref: TGMA:0000002 xref: UMLS:C0018670 {source="ncithesaurus:Head", source="BIRNLEX:1230"} xref: VHOG:0001644 xref: WBbt:0005739 xref: Wikipedia:Head xref: XAO:0003024 is_a: UBERON:0011676 ! subdivision of organism along main body axis relationship: BFO:0000050 UBERON:0007811 ! part of craniocervical region property_value: skos:prefLabel "head" xsd:string [Term] id: UBERON:0000035 name: primary ovarian follicle def: "An ovarian follicle that has one layer of granulosa cells." [GO:0001545, GOC:mtg_mpo, http://ovary.stanford.edu] subset: human_reference_atlas subset: pheno_slim synonym: "folliculus ovaricus primarius" EXACT OMO:0003011 [FMA:18634] synonym: "ovary primary follicle" EXACT [EMAPA:35631, MA:0002907] synonym: "preantral follicle of ovary" RELATED [] synonym: "primary egg follicle" RELATED [] synonym: "primary follicle" RELATED [EMAPA:35631] synonym: "primary follicle of ovary" EXACT [FMA:18634] synonym: "primary ovarian follicle" EXACT [FMA:18634] xref: BTO:0000410 xref: EMAPA:35631 xref: FMA:18634 xref: MA:0002907 xref: SCTID:258665002 is_a: UBERON:0001305 ! ovarian follicle intersection_of: UBERON:0001305 ! ovarian follicle intersection_of: RO:0002180 UBERON:0005170 {cardinality="1"} ! has component granulosa cell layer relationship: RO:0002180 UBERON:0005170 ! has component granulosa cell layer relationship: RO:0002202 UBERON:0003981 ! develops from primordial ovarian follicle property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0000036 name: secondary ovarian follicle def: "A maturing ovarian follicle that has two more more layers of granulosa cells, up to the onset of antrum formation." [GO:0001546, http://ovary.stanford.edu, http://www.repropedia.org/secondary-ovarian-follicle] subset: human_reference_atlas subset: pheno_slim synonym: "antral follicle of ovary" RELATED [FMA:18637] synonym: "folliculus ovaricus secondarius" EXACT [] synonym: "ovary secondary follicle" EXACT [MA:0002908] synonym: "pre-antral follicle" EXACT [GO:0001546] synonym: "pre-ovulatory follicle" RELATED [EMAPA:30777] synonym: "preantral follicle" EXACT [GO:0001546] synonym: "secondary egg follicle" RELATED [] synonym: "secondary follicle" RELATED [EMAPA:35632] synonym: "secondary follicle of ovary" EXACT [] xref: EMAPA:35632 xref: FMA:18637 xref: MA:0002908 is_a: UBERON:0001305 ! ovarian follicle intersection_of: UBERON:0001305 ! ovarian follicle intersection_of: RO:0002180 UBERON:0005170 {minCardinality="2"} ! has component granulosa cell layer intersection_of: RO:0002387 UBERON:0000037 ! has potential to develop into tertiary ovarian follicle relationship: RO:0002180 UBERON:0005170 ! has component granulosa cell layer relationship: RO:0002202 UBERON:0000035 ! develops from primary ovarian follicle relationship: RO:0002387 UBERON:0000037 ! has potential to develop into tertiary ovarian follicle property_value: IAO:0000116 "consider adopting distinction in MA" xsd:string property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0000037 name: tertiary ovarian follicle def: "A follicle that has reached the most mature stage of folliculogenesis, characterized by the presence of the antrum." [http://orcid.org/0000-0002-6601-2165, http://www.repropedia.org/antral-follicle] subset: pheno_slim subset: uberon_slim synonym: "antral follicle" BROAD [] synonym: "antral ovarian follicle" EXACT [GO:0001547] synonym: "folliculi ovarici vesiculosi" EXACT OMO:0003011 [FMA:18641, FMA:TA] synonym: "folliculus ovaricus tertiarius" EXACT [] synonym: "folliculus ovaricus tertiarius (vesiculosus)" EXACT [FMA:18641] synonym: "folliculus ovaricus tertiarius (vesiculous)" EXACT [] synonym: "Graafian follicle" EXACT [http://www.repropedia.org/antral-follicle] synonym: "ovary antral follicle" EXACT [http://www.repropedia.org/antral-follicle, MA:0002909] synonym: "tertiary egg follicle" RELATED [] synonym: "tertiary follicle of ovary" EXACT [FMA:18641, http://www.repropedia.org/antral-follicle] synonym: "vesicular follicle of ovary" EXACT [FMA:18641] synonym: "vesicular ovarian follicle" EXACT [FMA:18641] xref: EMAPA:30763 xref: FMA:18641 xref: MA:0002909 xref: NCIT:C32692 xref: SCTID:362261008 xref: UMLS:C0600225 {source="ncithesaurus:Graafian_Follicle"} is_a: UBERON:0001305 ! ovarian follicle intersection_of: UBERON:0001305 ! ovarian follicle intersection_of: BFO:0000051 UBERON:0000039 ! has part follicular antrum intersection_of: RO:0002180 UBERON:0005170 {minCardinality="2"} ! has component granulosa cell layer relationship: BFO:0000051 UBERON:0000039 ! has part follicular antrum relationship: RO:0002180 UBERON:0005170 ! has component granulosa cell layer relationship: RO:0002202 UBERON:0000036 ! develops from secondary ovarian follicle property_value: foaf:depiction "https://upload.wikimedia.org/wikipedia/commons/e/e6/Primary_follicle-4.JPG" xsd:anyURI [Term] id: UBERON:0000038 name: follicular fluid def: "The fluid surrounding the ovum and granulosa cells in the ovarian follicle." [ISBN:145114847X, MESH:D015571, Wikipedia:Follicular_fluid] subset: human_reference_atlas subset: uberon_slim synonym: "antral fluid, ovarian follicle" RELATED [] synonym: "liquor follicularis" EXACT [FMA:18665] synonym: "liquor folliculi" EXACT OMO:0003011 [] synonym: "liquor folliculi" RELATED OMO:0003011 [Wikipedia:Follicular_fluid] synonym: "ovarian follicular fluid" RELATED [BTO:0004383] synonym: "ovary follicle fluid" EXACT [MA:0002511] synonym: "ovary follicular fluid" RELATED [BTO:0004383] xref: BTO:0004383 xref: CALOHA:TS-0728 xref: FMA:18665 xref: GAID:372 xref: MA:0002511 xref: MESH:D015571 xref: NCIT:C52556 xref: UMLS:C1709369 {source="ncithesaurus:Ovarian_Follicle_Fluid"} xref: Wikipedia:Follicular_fluid is_a: BFO:0000002 is_a: UBERON:0000463 ! organism substance relationship: BFO:0000050 UBERON:0001305 ! part of ovarian follicle relationship: BFO:0000051 CHEBI:17089 ! has part relationship: BFO:0000051 UBERON:0000456 ! has part secretion of exocrine gland relationship: BFO:0000051 UBERON:0007779 ! has part transudate relationship: RO:0001025 UBERON:0000039 ! located in follicular antrum relationship: RO:0002221 CL:0000025 ! surrounds egg cell property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/8/81/Gray3.png" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0000039 name: follicular antrum def: "Region of ovarian follicle filled with follicular fluid." [Wikipedia:Follicular_antrum] subset: human_reference_atlas subset: uberon_slim synonym: "antral cavity" EXACT [FMA:18675] synonym: "antrum folliculare" EXACT [FMA:18675] synonym: "antrum follicularum" RELATED OMO:0003011 [Wikipedia:Follicular_antrum] synonym: "ovarian follicle antrum" EXACT [GO:0001548] xref: EMAPA:37867 {source="MA:th"} xref: FMA:18675 xref: Wikipedia:Follicular_antrum is_a: UBERON:0000464 ! anatomical space intersection_of: UBERON:0000464 ! anatomical space intersection_of: BFO:0000050 UBERON:0001305 ! part of ovarian follicle intersection_of: RO:0001015 UBERON:0000038 ! location of follicular fluid relationship: BFO:0000050 UBERON:0001305 ! part of ovarian follicle relationship: RO:0001015 UBERON:0000038 ! location of follicular fluid property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0000042 name: serous membrane def: "Multi-tissue structure that is comprised of a secretory epithelial layer (mesothelium) and a connective tissue layer." [https://github.com/obophenotype/uberon/issues/86, Wikipedia:Serous_membrane] subset: uberon_slim subset: vertebrate_core synonym: "serosa" RELATED [Wikipedia:Serous_membrane] synonym: "tunica serosa" EXACT OMO:0003011 [FMA:9581] synonym: "wall of serous sac" EXACT [FMA:9581] xref: FMA:9581 xref: GAID:19 xref: MESH:D012704 xref: NCIT:C13169 xref: SCTID:362878009 xref: TAO:0005425 xref: UMLS:C0036760 {source="ncithesaurus:Serosa"} xref: Wikipedia:Serous_membrane xref: ZFA:0005425 is_a: UBERON:0000481 ! multi-tissue structure is_a: UBERON:0004120 ! mesoderm-derived structure relationship: BFO:0000050 UBERON:0000060 ! part of anatomical wall relationship: BFO:0000051 UBERON:0001136 ! has part mesothelium relationship: BFO:0000051 UBERON:0002384 ! has part connective tissue property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/4/4e/Ens.png" xsd:anyURI property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/en/thumb/4/4e/Ens.png/200px-Ens.png" xsd:anyURI property_value: skos:prefLabel "serous membrane" xsd:string property_value: terms:contributor https://orcid.org/0000-0002-6601-2165 [Term] id: UBERON:0000043 name: tendon def: "Dense regular connective tissue that connects muscle to bone[VSAO]." [GO_REF:0000034, http://dx.plos.org/10.1371/journal.pone.0051070, VSAO:0000073, Wikipedia:Tendon] subset: pheno_slim subset: uberon_slim synonym: "sinew" RELATED [Wikipedia:Tendon] synonym: "tendo" RELATED OMO:0003011 [Wikipedia:Tendon] xref: AEO:0000091 xref: BTO:0001356 xref: CALOHA:TS-1021 xref: EHDAA2:0003091 xref: EMAPA:35854 xref: EV:0100149 xref: FMA:9721 xref: GAID:276 xref: galen:Tendon xref: MA:0000115 xref: MESH:D013710 xref: NCIT:C13045 xref: SCTID:256667004 xref: UMLS:C0039508 {source="ncithesaurus:Tendon"} xref: VHOG:0001286 xref: VSAO:0000073 xref: Wikipedia:Tendon xref: XAO:0000173 xref: ZFA:0005647 is_a: UBERON:0007846 {source="VSAO"} ! dense regular connective tissue relationship: BFO:0000050 UBERON:0002204 {source="OG"} ! part of musculoskeletal system relationship: BFO:0000051 CL:0000327 {source="AEO"} ! has part extracellular matrix secreting cell relationship: RO:0002176 UBERON:0001474 ! connects bone element relationship: RO:0002176 UBERON:0001630 ! connects muscle organ property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/3/3c/Achilles-tendon.jpg" xsd:anyURI property_value: skos:prefLabel "tendon" xsd:string [Term] id: UBERON:0000044 name: dorsal root ganglion def: "Sensory ganglia located on the dorsal spinal roots within the vertebral column. The spinal ganglion cells are pseudounipolar. The single primary branch bifurcates sending a peripheral process to carry sensory information from the periphery and a central branch which relays that information to the spinal cord or brain. (MSH) * ganglion found on the posterior root of each spinal nerve, composed of the unipolar nerve cell bodies of the sensory neurons of the nerve. (CSP)." [BIRNLEX:2596] subset: efo_slim subset: human_reference_atlas subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "dorsal root ganglia" RELATED OMO:0003004 [] synonym: "dorsal root ganglion" EXACT [BTO:0001264] synonym: "DRG" RELATED OMO:0003000 [] synonym: "ganglion of dorsal root" EXACT [OBOL:automatic] synonym: "ganglion sensorium nervi spinalis" RELATED OMO:0003011 [BTO:0001264, Wikipedia:Dorsal_root_ganglion] synonym: "ganglion spinale" RELATED [BTO:0001264] synonym: "ganglion spinalis" EXACT [FMA:5888] synonym: "posterior root ganglion" RELATED [EMAPA:16668] synonym: "spinal ganglion" EXACT [FMA:5888] synonym: "spinal ganglion part of peripheral nervous system" EXACT [BIRNLEX:2598] xref: AAO:0011032 xref: BIRNLEX:2596 xref: BIRNLEX:2598 xref: BTO:0001264 xref: CALOHA:TS-0954 xref: EFO:0000900 xref: EHDAA2:0000418 xref: EHDAA2:0001897 xref: EHDAA:2899 xref: EMAPA:16667 xref: EMAPA:16668 xref: EMAPA:18372 xref: EV:0100373 xref: FMA:5888 xref: MA:0000231 xref: MA:0000232 xref: MAT:0000162 xref: MESH:D005727 {sssom:mapping_justification="https://w3id.org/semapv/vocab/LexicalMatching"} xref: MIAA:0000162 xref: NCIT:C12462 xref: SCTID:244455004 xref: TAO:0000200 xref: UMLS:C0017070 {source="ncithesaurus:Dorsal_Root_Ganglion", source="BIRNLEX:2596"} xref: VHOG:0000222 xref: Wikipedia:Dorsal_root_ganglion xref: XAO:0000210 xref: ZFA:0000200 is_a: UBERON:0001800 {source="MA"} ! sensory ganglion intersection_of: UBERON:0000045 ! ganglion intersection_of: extends_fibers_into UBERON:0001780 ! spinal nerve intersection_of: extends_fibers_into UBERON:0002261 ! dorsal root of spinal cord relationship: extends_fibers_into UBERON:0001780 ! spinal nerve relationship: extends_fibers_into UBERON:0002261 ! dorsal root of spinal cord relationship: RO:0002202 UBERON:0003083 {source="DOI:10.1101/gr.157586.113", source="ZFA", source="https://github.com/obophenotype/uberon/wiki/The-neural-crest"} ! develops from trunk neural crest property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/7/71/DRG_Chicken_e7.jpg" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 property_value: seeAlso "https://github.com/obophenotype/uberon/issues/2644" xsd:string [Term] id: UBERON:0000045 name: ganglion def: "A biological tissue mass, most commonly a mass of nerve cell bodies." [https://github.com/obophenotype/uberon/issues/300, Wikipedia:Ganglion] subset: efo_slim subset: human_reference_atlas subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "ganglia" RELATED [] synonym: "neural ganglion" RELATED [BTO:0000497] xref: AAO:0010426 xref: AEO:0000135 xref: BAMS:G xref: BTO:0000497 xref: CALOHA:TS-0397 xref: EFO:0000899 xref: EHDAA2:0003135 xref: EHDAA:2897 xref: EHDAA:4662 xref: EHDAA:5621 xref: EHDAA:918 xref: EMAPA:32846 xref: EV:0100372 xref: FMA:5884 xref: MA:0002406 xref: MAT:0000207 xref: MAT:0000343 xref: MESH:D005724 xref: MIAA:0000207 xref: MIAA:0000343 xref: NCIT:C12719 xref: NLXANAT:100302 xref: TAO:0000190 xref: TGMA:0001016 xref: UMLS:C0017067 {source="ncithesaurus:Ganglion"} xref: VHOG:0000156 xref: WBbt:0005189 xref: Wikipedia:Ganglion xref: XAO:0000209 xref: ZFA:0000190 is_a: BFO:0000002 is_a: UBERON:0000061 {source="https://github.com/obophenotype/uberon/issues/2495#issuecomment-1187364719"} ! anatomical structure relationship: BFO:0000050 UBERON:0001016 ! part of nervous system relationship: RO:0002473 UBERON:0003714 {source="EHDAA2"} ! composed primarily of neural tissue relationship: RO:0002495 UBERON:0003869 {source="Bgee:AN"} ! immediate transformation of presumptive ganglion property_value: IAO:0000116 "TODO - check vert vs invert. Other species: Any of a number of aggregations of neurons, glial cells and their processes, surrounded by a glial cell and connective tissue sheath (plural: ganglia). // Subdivision of neural tree (organ) which primarily consists of cell bodies of neurons located outside the neuraxis (brain and spinal cord); together with a nucleus and its associated nerve, it constitutes a neural tree (organ). Examples: spinal ganglion, trigeminal ganglion, superior cervical ganglion, celiac ganglion, inferior hypogastric (pelvic) ganglion. // a cluster of nerve cells and associated glial cells (nuclear location) // Portion of tissue that contains cell bodies of neurons and is located outside the central nervous system." xsd:string property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "ganglion" xsd:string property_value: terms:contributor https://orcid.org/0000-0002-6601-2165 [Term] id: UBERON:0000047 name: simple eye def: "An eye with one concave chamber. Note that 'simple' does not imply a reduced level of complexity or acuity." [Wikipedia:Eye#Simple_eyes] subset: grouping_class subset: uberon_slim xref: TGMA:0000729 xref: Wikipedia:Eye#Simple_eyes is_a: UBERON:0000970 ! eye property_value: skos:prefLabel "simple eye" xsd:string [Term] id: UBERON:0000052 name: fornix of brain def: "A C-shaped bundle of fibres (axons) in the brain, and carries signals from the hippocampus to the mammillary bodies and septal nuclei. It is typically divided into the columns (crus), body, commissure and the pre-commissural and post-commissural fornix (MM)." [BIRNLEX:705] subset: human_reference_atlas subset: pheno_slim subset: uberon_slim synonym: "brain fornix" EXACT [] synonym: "cerebral fornix" EXACT [] synonym: "forebrain fornix" EXACT [FMA:61965] synonym: "fornix" BROAD [] synonym: "fornix (column and body of fornix)" RELATED [FMA:61965] synonym: "fornix cerebri" RELATED OMO:0003011 [NeuroNames:268] synonym: "fornix hippocampus" RELATED [] synonym: "fornix of neuraxis" EXACT [FMA:83865] synonym: "hippocampus fornix" RELATED [] synonym: "neuraxis fornix" EXACT [FMA:83865] xref: BAMS:f xref: BIRNLEX:705 xref: DHBA:10576 xref: DMBA:17767 xref: EMAPA:35352 xref: FMA:83865 xref: HBA:9249 xref: MA:0002747 xref: NCIT:C32289 xref: neuronames:268 {source="BIRNLEX:705"} xref: SCTID:279302004 xref: UMLS:C0152334 {source="BIRNLEX:705"} xref: UMLS:C0458370 {source="ncithesaurus:Cerebral_Fornix"} xref: Wikipedia:fornix_of_brain is_a: UBERON:0007702 ! tract of brain relationship: BFO:0000050 UBERON:0002421 {source="NIFSTD"} ! part of hippocampal formation relationship: extends_fibers_into UBERON:0002206 ! mammillary body relationship: extends_fibers_into UBERON:0002663 ! septal nuclear complex property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/2/21/Gray747.png" xsd:anyURI property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/brain-female/v1.4/assets/3d-allen-f-brain.glb" xsd:anyURI property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/brain-male/v1.4/assets/3d-allen-m-brain.glb" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "fornix of brain" xsd:string [Term] id: UBERON:0000053 name: macula lutea def: "An oval area in the retina, usually located temporal to the posterior pole of the eye and slightly below the level of the optic disk. It is characterized by the presence of a yellow pigment diffusely permeating the inner layers, contains the fovea centralis in its center, and provides the best phototopic visual acuity. It is devoid of retinal blood vessels, except in its periphery, and receives nourishment from the choriocapillaris of the choroid. (From Cline et al., Dictionary of Visual Science, 4th ed)." [MESH:A09.371.729.522] subset: pheno_slim subset: uberon_slim synonym: "macula" RELATED [] synonym: "macula flava retinae" RELATED [BTO:0003015] synonym: "macula retinae" RELATED [BTO:0003015] synonym: "maculae" RELATED [] xref: BIRNLEX:2540 xref: BTO:0003015 xref: EMAPA:36516 xref: EV:0100349 xref: FMA:58637 xref: GAID:909 xref: MA:0001306 xref: MESH:D008266 xref: NCIT:C26464 xref: NCIT:C33044 xref: SCTID:362517001 xref: UMLS:C0450295 {source="ncithesaurus:Macula_Lutea", source="BIRNLEX:2540"} xref: UMLS:C1284755 {source="BIRNLEX:2540"} xref: Wikipedia:Macula_of_retina is_a: UBERON:0000064 ! organ part disjoint_from: UBERON:0000054 ! macula relationship: BFO:0000050 UBERON:0000966 ! part of retina property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/e/ed/Human_eye_cross-sectional_view_grayscale.png" xsd:anyURI [Term] id: UBERON:0000054 name: macula def: "Thickened areas of the saccule or utricle where the termination of the vestibular nerve occurs[MESH,modified]." [MESH:A09.246.631.909.625.125] subset: human_reference_atlas subset: pheno_slim subset: uberon_slim synonym: "acoustic macula" RELATED [MESH:A09.246.631.909.625.125] synonym: "acoustic maculae" RELATED OMO:0003004 [MESH:A09.246.631.909.625.125] synonym: "macula" EXACT [] synonym: "maculae" EXACT OMO:0003004 [] synonym: "sensory macula" EXACT [ZFA:0000386] synonym: "sensory patch" EXACT [ZFA:0000386] xref: GAID:777 xref: MESH:D008267 xref: TAO:0000386 xref: ZFA:0000386 is_a: UBERON:0000479 ! tissue relationship: BFO:0000050 UBERON:0001846 ! part of internal ear relationship: BFO:0000051 GO:0070451 ! has part cell hair property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0000055 name: vessel def: "A tubular structure that contains, conveys body fluid, such as blood or lymph." [https://orcid.org/0000-0002-6601-2165] subset: grouping_class subset: human_reference_atlas subset: pheno_slim is_a: UBERON:0004111 ! anatomical conduit relationship: channel_for UBERON:0006314 ! bodily fluid property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "vessel" xsd:string [Term] id: UBERON:0000056 name: ureter def: "Muscular duct that propels urine from the kidneys to the urinary bladder, or related organs." [GO:0090189, Wikipedia:Ureter] subset: efo_slim subset: human_reference_atlas subset: major_organ subset: organ_slim subset: pheno_slim subset: uberon_slim synonym: "metanephric duct" RELATED [ISBN:0073040584, VHOG:0000605] xref: AAO:0010254 xref: BTO:0001409 xref: CALOHA:TS-1084 xref: EFO:0000930 xref: EHDAA2:0002139 xref: EHDAA:9341 xref: EMAPA:17950 xref: EV:0100097 xref: FMA:9704 xref: GAID:438 xref: galen:Ureter xref: MA:0000378 xref: MAT:0000120 xref: MESH:D014513 xref: MIAA:0000120 xref: NCIT:C12416 xref: SCTID:302511008 xref: UMLS:C0041951 {source="ncithesaurus:Ureter"} xref: VHOG:0000605 xref: Wikipedia:Ureter xref: XAO:0000144 is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0005179 ! pelvic region element is_a: UBERON:0006555 ! excretory tube is_a: UBERON:0015212 ! lateral structure relationship: BFO:0000050 UBERON:0036295 ! part of renal pelvis/ureter relationship: BSPO:0000126 UBERON:0000468 ! multicellular organism relationship: channel_for UBERON:0001088 ! urine relationship: channels_from UBERON:0001224 ! renal pelvis relationship: channels_into UBERON:0001255 ! urinary bladder relationship: RO:0002202 UBERON:0005081 {source="GO"} ! develops from ureter ureteric bud property_value: foaf:depiction "https://upload.wikimedia.org/wikipedia/commons/3/30/Urinary_system.svg" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0000057 name: urethra def: "The fibromuscular tubular canal through which urine is discharged from the bladder to the exterior via the external urinary meatus; in males, the urethra is joined by the ejaculatory ducts and serves as a passageway for semen during ejaculation, as well as a canal for urine during voiding; in females, the urethra is shorter and emerges above the vaginal opening." [MGI:anna, MP:0000537] subset: efo_slim subset: major_organ subset: organ_slim subset: pheno_slim subset: uberon_slim xref: BTO:0001426 xref: CALOHA:TS-1132 xref: EFO:0000931 xref: EMAPA:30901 xref: EV:0100099 xref: FMA:19667 xref: GAID:390 xref: galen:Urethra xref: MA:0000379 xref: MAT:0000121 xref: MESH:D014521 xref: MIAA:0000121 xref: NCIT:C12417 xref: SCTID:302513006 xref: UMLS:C0041967 {source="ncithesaurus:Urethra"} xref: VHOG:0001264 xref: Wikipedia:Urethra xref: XAO:0000153 is_a: UBERON:0000062 ! organ is_a: UBERON:0004111 ! anatomical conduit is_a: UBERON:0004120 ! mesoderm-derived structure relationship: BFO:0000050 UBERON:0001556 ! part of lower urinary tract relationship: channel_for UBERON:0001088 ! urine relationship: channels_from UBERON:0001255 ! urinary bladder relationship: RO:0002150 UBERON:0001255 ! continuous with urinary bladder relationship: RO:0002202 UBERON:0000164 ! develops from primitive urogenital sinus relationship: RO:0002202 UBERON:0013241 {source="Wikipedia"} ! develops from embryonic urethral groove relationship: RO:0002216 GO:0060073 ! capable of part of micturition property_value: foaf:depiction "https://upload.wikimedia.org/wikipedia/commons/c/cb/Female_anatomy.png" xsd:anyURI [Term] id: UBERON:0000058 name: duct def: "A tubular structure that transports secreted or excreted substances." [http://orcid.org/0000-0002-6601-2165, http://www.siumed.edu/~dking2/intro/glands.htm#ducts] subset: grouping_class synonym: "anatomical duct" EXACT [] synonym: "ducts" RELATED OMO:0003004 [XAO:0004000] synonym: "exocrine duct" NARROW [] synonym: "exocrine gland duct" NARROW [] xref: AAO:0011123 xref: FBbt:00100314 {sssom:mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"} xref: FMA:30320 xref: galen:Duct xref: NCIT:C12948 xref: SCTID:91726008 xref: TAO:0005171 xref: UMLS:C0687028 {source="ncithesaurus:Duct"} xref: Wikipedia:Duct_(anatomy) xref: XAO:0004000 xref: ZFA:0005171 is_a: UBERON:0000063 ! organ subunit relationship: BFO:0000051 UBERON:0034969 ! has part epithelial layer of duct relationship: RO:0000086 PATO:0002299 ! has quality tubular relationship: RO:0002570 UBERON:0000463 ! conduit for organism substance property_value: skos:prefLabel "duct" xsd:string [Term] id: UBERON:0000059 name: large intestine def: "A subdivision of the digestive tract that connects the small intestine to the cloaca or anus. Lacks or has few villi[Kardong]." [ISBN:0073040584, Wikipedia:Large_intestine_(anatomy)] subset: efo_slim subset: human_reference_atlas subset: major_organ subset: organ_slim subset: pheno_slim synonym: "intestinum crassum" RELATED [BTO:0000706] xref: AAO:0010396 xref: BTO:0000706 xref: CALOHA:TS-1306 xref: EFO:0000840 xref: EMAPA:19252 xref: EV:0100077 xref: FMA:7201 xref: GAID:306 xref: galen:LargeIntestine xref: MA:0000333 xref: MESH:D007420 xref: MIAA:0000046 xref: NCIT:C12379 xref: SCTID:181254001 xref: UMLS:C0021851 {source="ncithesaurus:Large_Intestine"} xref: VHOG:0000054 xref: Wikipedia:Large_intestine_(anatomy) xref: XAO:0000131 is_a: UBERON:0004921 {source="cjm"} ! subdivision of digestive tract is_a: UBERON:0013765 ! digestive system element relationship: BFO:0000050 UBERON:0000160 ! part of intestine relationship: BFO:0000050 UBERON:0004907 ! part of lower digestive tract relationship: RO:0002162 NCBITaxon:7742 ! in taxon Vertebrata relationship: RO:0002433 UBERON:0000160 ! contributes to morphology of intestine property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/large-intestine-female/v1.3/assets/3d-sbu-f-large-intestine.glb" xsd:anyURI property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/large-intestine-male/v1.3/assets/3d-sbu-m-large-intestine.glb" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "large intestine" xsd:string [Term] id: UBERON:0000060 name: anatomical wall def: "Organ component adjacent to an organ cavity and which consists of a maximal aggregate of organ component layers." [FMA:82482] subset: upper_level synonym: "organ wall" RELATED [FMA:82482] synonym: "wall" BROAD [] synonym: "wall of organ" EXACT [FMA:82482] xref: FMA:82482 xref: galen:Wall is_a: UBERON:0000064 ! organ part relationship: BFO:0000051 UBERON:0004923 ! has part organ component layer relationship: RO:0002220 UBERON:0002553 ! adjacent to anatomical cavity property_value: skos:prefLabel "anatomical wall" xsd:string [Term] id: UBERON:0000061 name: anatomical structure def: "Material anatomical entity that is a single connected structure with inherent 3D shape generated by coordinated expression of the organism's own genome." [CARO:0000003] subset: common_anatomy subset: human_reference_atlas subset: upper_level synonym: "biological structure" EXACT [] synonym: "connected biological structure" EXACT [CARO:0000003] xref: AAO:0010825 xref: AEO:0000003 xref: BILA:0000003 xref: CARO:0000003 xref: EHDAA2:0003003 xref: EMAPA:0 xref: FAO:0000001 xref: FBbt:00007001 {sssom:mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"} xref: FMA:305751 xref: FMA:67135 xref: GAID:781 xref: HAO:0000003 xref: http://dbpedia.org/ontology/AnatomicalStructure xref: MA:0003000 xref: MESH:D000825 xref: SCTID:362889002 xref: TAO:0000037 xref: TGMA:0001823 xref: VHOG:0001759 xref: XAO:0003000 xref: ZFA:0000037 is_a: BFO:0000004 is_a: UBERON:0000465 ! material anatomical entity relationship: RO:0002497 UBERON:0000071 ! existence ends during or before death stage property_value: RO:0002175 NCBITaxon:33090 property_value: RO:0002175 NCBITaxon:33208 property_value: RO:0002175 NCBITaxon:4751 property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "anatomical structure" xsd:string [Term] id: UBERON:0000062 name: organ def: "Anatomical structure that performs a specific function or group of functions [WP]." [Wikipedia:Organ_(anatomy)] subset: common_anatomy subset: upper_level synonym: "anatomical unit" RELATED [] synonym: "body organ" RELATED [] synonym: "element" RELATED [http://orcid.org/0000-0002-6601-2165] xref: BIRNLEX:4 xref: CARO:0020004 xref: EFO:0000634 xref: EMAPA:35949 xref: ENVO:01000162 xref: FMA:67498 xref: MA:0003001 xref: NCIT:C13018 xref: SCTID:272625005 xref: UMLS:C0178784 {source="ncithesaurus:Organ"} xref: WBbt:0003760 xref: Wikipedia:Organ_(anatomy) is_a: UBERON:0010000 ! multicellular anatomical structure disjoint_from: UBERON:0002095 {source="PMID:28192867"} ! mesentery disjoint_from: UBERON:0034921 ! multi organ part structure relationship: BFO:0000050 UBERON:0000467 ! part of anatomical system relationship: RO:0002002 UBERON:0006984 ! has 2D boundary anatomical surface relationship: RO:0002215 GO:0008150 ! capable of biological_process property_value: RO:0002161 NCBITaxon:110815 {source="Wikipedia"} property_value: RO:0002175 NCBITaxon:33090 property_value: RO:0002175 NCBITaxon:33208 property_value: RO:0002175 NCBITaxon:4751 property_value: skos:prefLabel "organ" xsd:string [Term] id: UBERON:0000063 name: organ subunit def: "A part of an organ that constitutes a distinct modular sub-unit. In some cases, the organ may also contain other sub-units of identical or similar types, in other cases this may be a distinct entity." [http://orcid.org/0000-0002-6601-2165] subset: upper_level synonym: "organ region with fixed fiat boundary" RELATED [FMA:86140] synonym: "organ segment" RELATED [FMA:86140] synonym: "segment of organ" RELATED [FMA:86140] xref: FMA:86140 is_a: UBERON:0000064 ! organ part property_value: IAO:0000116 "FMA distinguishes segment from zone by whether the fiat boundaries are fixed/anchored (segments) or floating (zone). It's not completely clear how to apply this distinction" xsd:string property_value: skos:prefLabel "organ subunit" xsd:string [Term] id: UBERON:0000064 name: organ part def: "A multicellular structure that is a part of an organ." [http://orcid.org/0000-0002-6601-2165] subset: common_anatomy subset: efo_slim subset: non_informative subset: upper_level synonym: "cardinal organ part" EXACT [FMA:82472] synonym: "regional part of organ" RELATED [BIRNLEX:16] xref: AAO:0011124 xref: BIRNLEX:16 xref: EFO:0000635 xref: FMA:82472 xref: SCTID:113343008 xref: SCTID:91717005 is_a: UBERON:0010000 ! multicellular anatomical structure relationship: BFO:0000050 UBERON:0000062 ! part of organ property_value: RO:0002175 NCBITaxon:33090 property_value: RO:0002175 NCBITaxon:33208 property_value: RO:0002175 NCBITaxon:4751 property_value: skos:prefLabel "organ part" xsd:string [Term] id: UBERON:0000065 name: respiratory tract def: "Anatomical structure that is part of the respiratory system. In mammals consists of upper and lower tracts." [https://orcid.org/0000-0002-6601-2165] subset: human_reference_atlas xref: EHDAA2:0001606 xref: EHDAA:1568 xref: EHDAA:2219 xref: EMAPA:16737 xref: FMA:265130 xref: SCTID:361110005 xref: VHOG:0000393 is_a: BFO:0000002 is_a: UBERON:0001005 ! respiratory airway relationship: RO:0002202 UBERON:0007026 {source="NCBIBook:NBK10107"} ! develops from presumptive gut relationship: RO:0002202 UBERON:0008947 ! develops from respiratory primordium property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "respiratory tract" xsd:string [Term] id: UBERON:0000066 name: fully formed stage def: "The stage of development at which the animal is fully formed, including immaturity and maturity. Includes both sexually immature stage, and adult stage." [https://orcid.org/0000-0002-6601-2165] subset: efo_slim synonym: "adult stage" BROAD [] synonym: "fully formed animal stage" EXACT [] synonym: "juvenile-adult stage" EXACT [] xref: BilaDO:0000004 xref: BtauDv:0000078 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: BTO:0001043 xref: CfamDv:0000007 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: ChirDv:0000014 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: DpseDv:0000005 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: DsimDv:0000005 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: EcabDv:0000007 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: EFO:0001272 xref: FBdv:00005369 xref: FcatDv:0000007 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: GgalDv:0000076 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: GgorDv:0000032 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: HsapDv:0010000 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: MmulDv:0000052 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: MmusDv:0000092 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: OanaDv:0000007 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: OariDv:0000024 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: PpanDv:0000041 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: PtroDv:0000052 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: RnorDv:0000061 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: SsalDv:0000040 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: SscrDv:0000084 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: WBls:0000041 xref: XtroDO:0000084 is_a: BFO:0000003 is_a: UBERON:0000105 ! life cycle stage relationship: BFO:0000050 UBERON:0000092 ! part of post-embryonic stage relationship: BFO:0000062 UBERON:0000111 ! preceded by organogenesis stage relationship: BFO:0000063 UBERON:0000071 ! precedes death stage property_value: seeAlso "https://github.com/obophenotype/uberon/issues/566" xsd:anyURI property_value: skos:prefLabel "fully formed stage" xsd:string [Term] id: UBERON:0000068 name: embryo stage def: "A life cycle stage that starts with fertilization and ends with the fully formed embryo." [http://orcid.org/0000-0002-6601-2165] synonym: "embryogenesis" RELATED [] synonym: "embryonic stage" EXACT [] xref: AcarDv:0000002 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: BilaDO:0000002 xref: BtauDv:0000002 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: CfamDv:0000002 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: ChirDv:0000002 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: CporDv:0000002 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: DpseDv:0000002 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: DsimDv:0000002 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: EcabDv:0000002 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: EV:0300001 xref: FBdv:00005289 xref: FcatDv:0000002 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: FMA:72652 xref: GgalDv:0000002 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: GgorDv:0000002 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: HsapDv:0000045 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: MdomDv:0000002 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: MmulDv:0000002 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: MmusDv:0000042 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: OanaDv:0000002 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: OariDv:0000002 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: OcunDv:0000002 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: OGES:000000 xref: OGES:000022 xref: PpanDv:0000002 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: PtroDv:0000002 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: RnorDv:0000002 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: SCTID:296280003 xref: SsalDv:0000002 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: SscrDv:0000002 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: WBls:0000003 xref: WBls:0000092 xref: WBls:0000102 xref: XAO:1000012 is_a: BFO:0000003 is_a: UBERON:0000105 ! life cycle stage disjoint_from: UBERON:0000092 ! post-embryonic stage relationship: BFO:0000063 UBERON:0000066 ! precedes fully formed stage relationship: BFO:0000063 UBERON:0000092 ! precedes post-embryonic stage relationship: RO:0002082 GO:0009790 ! simultaneous with embryo development property_value: skos:prefLabel "embryo stage" xsd:string [Term] id: UBERON:0000069 name: larval stage def: "A distinct juvenile stage many animals undergo before metamorphosis into adults. Animals with indirect development such as insects, amphibians, or cnidarians typically have a larval phase of their life cycle." [Wikipedia:Larva] subset: efo_slim synonym: "ammocoete" NARROW SENSU [Wikipedia:Larva] synonym: "ammocoete stage" NARROW SENSU [Wikipedia:Larva] synonym: "bipinnaria" NARROW SENSU [Wikipedia:Larva] synonym: "bipinnaria stage" NARROW SENSU [Wikipedia:Larva] synonym: "caterpillar" NARROW SENSU [Wikipedia:Larva] synonym: "caterpillar stage" NARROW SENSU [Wikipedia:Larva] synonym: "glochidium" NARROW SENSU [Wikipedia:Larva] synonym: "glochidium stage" NARROW SENSU [Wikipedia:Larva] synonym: "grub" NARROW SENSU [Wikipedia:Larva] synonym: "grub stage" NARROW SENSU [Wikipedia:Larva] synonym: "larva" RELATED [] synonym: "larva stage" EXACT [] synonym: "leptocephalus" NARROW SENSU [Wikipedia:Larva] synonym: "leptocephalus stage" NARROW SENSU [Wikipedia:Larva] synonym: "maggot" NARROW SENSU [Wikipedia:Larva] synonym: "maggot stage" NARROW SENSU [Wikipedia:Larva] synonym: "metacestode" NARROW SENSU [BTO:0000859] synonym: "naiad, nymph" NARROW SENSU [Wikipedia:Larva] synonym: "naiad, nymph stage" NARROW SENSU [Wikipedia:Larva] synonym: "nauplius" NARROW SENSU [Wikipedia:Larva] synonym: "nauplius stage" NARROW SENSU [Wikipedia:Larva] synonym: "nymph" NARROW SENSU [Wikipedia:Larva] synonym: "nymph stage" NARROW SENSU [Wikipedia:Larva] synonym: "planula" NARROW SENSU [Wikipedia:Larva] synonym: "planula stage" NARROW SENSU [Wikipedia:Larva] synonym: "tornaria" NARROW SENSU [NCBITaxon:10219] synonym: "trochophore" NARROW SENSU [Wikipedia:Larva] synonym: "trochophore stage" NARROW SENSU [Wikipedia:Larva] synonym: "veliger" NARROW SENSU [Wikipedia:Larva] synonym: "veliger stage" NARROW SENSU [Wikipedia:Larva] synonym: "wriggler" NARROW SENSU [Wikipedia:Larva] synonym: "wriggler stage" NARROW SENSU [Wikipedia:Larva] synonym: "zoea" NARROW SENSU [Wikipedia:Larva] synonym: "zoea stage" NARROW SENSU [Wikipedia:Larva] xref: BTO:0000915 xref: BTO:0000954 xref: DpseDv:0000003 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: DsimDv:0000003 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: EFO:0001303 xref: MIAA:0000400 xref: OGES:000008 xref: SsalDv:0000039 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: Wikipedia:Larva xref: ZFS:0000048 is_a: BFO:0000003 is_a: UBERON:0000105 ! life cycle stage relationship: BFO:0000050 UBERON:0000092 ! part of post-embryonic stage relationship: RO:0002082 GO:0002164 ! simultaneous with larval development relationship: RO:0002087 UBERON:0000068 ! immediately preceded by embryo stage property_value: RO:0002161 NCBITaxon:32524 [Term] id: UBERON:0000071 name: death stage def: "End of the life of an organism." [XAO:0000437] subset: common_anatomy synonym: "death" RELATED [] xref: XAO:0000437 xref: XtroDO:0000085 is_a: BFO:0000003 is_a: UBERON:0000105 ! life cycle stage relationship: RO:0002229 UBERON:0000104 ! ends life cycle property_value: RO:0002175 NCBITaxon:33090 property_value: RO:0002175 NCBITaxon:33208 property_value: RO:0002175 NCBITaxon:4751 property_value: skos:prefLabel "death stage" xsd:string [Term] id: UBERON:0000072 name: proximo-distal subdivision of respiratory tract def: "An section of a respiratory tract." [http://orcid.org/0000-0002-6601-2165] subset: human_reference_atlas subset: non_informative synonym: "respiratory tract" RELATED [MA:0000434] synonym: "subdivision of respiratory tract" RELATED [] xref: FMA:45660 xref: MA:0000434 is_a: UBERON:0013522 ! subdivision of tube intersection_of: UBERON:0013522 ! subdivision of tube intersection_of: BFO:0000050 UBERON:0000065 ! part of respiratory tract relationship: BFO:0000050 UBERON:0000065 ! part of respiratory tract property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "proximo-distal subdivision of respiratory tract" xsd:string [Term] id: UBERON:0000073 name: regional part of nervous system def: "Any part or collection of parts of the central or peripheral nervous system. Parts may span both CNS and PNS." [BIRNLEX:1157] subset: non_informative subset: upper_level synonym: "part of nervous system" EXACT [BIRNLEX:1157] xref: BIRNLEX:1157 xref: NCIT:C13040 xref: SCTID:25087005 xref: UMLS:C1518256 {source="ncithesaurus:Nervous_System_Part"} is_a: UBERON:0000481 ! multi-tissue structure intersection_of: UBERON:0000481 ! multi-tissue structure intersection_of: BFO:0000050 UBERON:0001016 ! part of nervous system relationship: BFO:0000050 UBERON:0001016 ! part of nervous system property_value: skos:prefLabel "regional part of nervous system" xsd:string property_value: terms:contributor https://orcid.org/0000-0001-9114-8737 creation_date: 2009-06-18T09:00:04Z [Term] id: UBERON:0000074 name: renal glomerulus def: "A capillary tuft which forms a close network with the visceral epithelium (podocytes) and the mesangium to form the filtration barrier and is surrounded by Bowman's capsule in nephrons of the vertebrate kidney[GO]." [MP:0005325, Wikipedia:Glomerulus] subset: efo_slim subset: human_reference_atlas subset: pheno_slim subset: vertebrate_core synonym: "glomerular capillary tuft" RELATED [ZFA:0001288] synonym: "glomerular tuft" RELATED INCONSISTENT [] synonym: "glomerulus" BROAD [] synonym: "glomerulus renis" RELATED OMO:0003011 [Wikipedia:Glomerulus] synonym: "Malphigian glomerulus" RELATED MISSPELLING [BTO:0000530] synonym: "Malpighian glomerulus" RELATED [http://medical-dictionary.thefreedictionary.com/malpighian+glomerulus] synonym: "Malpighian tuft" RELATED [http://medical-dictionary.thefreedictionary.com/malpighian+glomerulus] synonym: "renal corpuscle" RELATED INCONSISTENT [] synonym: "renal glomeruli" EXACT [TAO:0001288] xref: BTO:0000530 xref: CALOHA:TS-0862 xref: EFO:0003667 xref: EMAPA:28329 xref: EV:0100386 xref: FMA:15624 xref: MA:0001657 xref: MESH:D007678 xref: NCIT:C13250 xref: SCTID:362217000 xref: TAO:0001288 xref: UMLS:C0022663 {source="ncithesaurus:Glomerulus"} xref: Wikipedia:Glomerulus xref: ZFA:0001288 is_a: UBERON:0000064 ! organ part is_a: UBERON:0004120 ! mesoderm-derived structure relationship: BFO:0000050 UBERON:0001229 {source="FMA", source="MA"} ! part of renal corpuscle relationship: RO:0002202 UBERON:0005749 ! develops from glomerular tuft relationship: RO:0002219 UBERON:0001230 ! surrounded by glomerular capsule property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/3/30/Gray1130.svg" xsd:anyURI property_value: foaf:depiction "https://upload.wikimedia.org/wikipedia/commons/2/22/Renal_corpuscle.svg" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 property_value: terms:contributor https://orcid.org/0000-0001-9114-8737 creation_date: 2009-06-18T09:26:37Z [Term] id: UBERON:0000075 name: subdivision of skeletal system def: "Anatomical cluster consisting of the skeletal elements and articular elements that are part of an individual subdivision of the organism." [https://orcid.org/0000-0002-6601-2165, UBERONREF:0000003] subset: non_informative synonym: "skeletal system part" RELATED [] synonym: "skeletal system subdivision" EXACT [FMA:85544] xref: FMA:85544 xref: galen:ComplexSkeletalStructure xref: NCIT:C34076 xref: SCTID:118966000 xref: UMLS:C1519343 {source="ncithesaurus:Skeletal_System_Part"} is_a: UBERON:0011216 {source="cjm"} ! organ system subdivision relationship: BFO:0000050 UBERON:0001434 ! part of skeletal system relationship: RO:0002162 NCBITaxon:7711 ! in taxon Chordata relationship: RO:0002473 UBERON:0004765 ! composed primarily of skeletal element property_value: skos:prefLabel "subdivision of skeletal system" xsd:string [Term] id: UBERON:0000076 name: external ectoderm def: "The surface (external) layer of ectoderm which begins to proliferate shortly after separation from the neuroectoderm." [MGI:anna, MP:0012532] subset: pheno_slim synonym: "surface (external) ectoderm" EXACT [] synonym: "surface ectoderm" EXACT [MP:0012532] xref: EHDAA2:0001968 xref: EHDAA:1494 xref: EHDAA:350 xref: EHDAA:4784 xref: EHDAA:4790 xref: EHDAA:4796 xref: EHDAA:7860 xref: EMAPA:16096 xref: FMA:87656 xref: NCIT:C34309 xref: UMLS:C1515087 {source="ncithesaurus:Surface_Ectoderm"} xref: Wikipedia:External_ectoderm is_a: UBERON:0000490 {source="EHDAA2"} ! unilaminar epithelium is_a: UBERON:0005291 ! embryonic tissue relationship: BFO:0000050 UBERON:0000924 {source="EHDAA2"} ! part of ectoderm property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/1/1d/Ectoderm.png" xsd:anyURI property_value: IAO:0000116 "merge with non-neural. In vertebrates, the ectoderm has three parts: external ectoderm (also known as surface ectoderm), the neurectoderm (neural crest, and neural tube)" xsd:string property_value: skos:prefLabel "external ectoderm" xsd:string [Term] id: UBERON:0000077 name: mixed endoderm/mesoderm-derived structure def: "An anatomical structure that develops from the endoderm and the mesoderm." [https://orcid.org/0000-0002-6601-2165] subset: grouping_class is_a: UBERON:0004119 ! endoderm-derived structure is_a: UBERON:0004120 ! mesoderm-derived structure intersection_of: UBERON:0000061 ! anatomical structure intersection_of: RO:0002202 UBERON:0000925 ! develops from endoderm intersection_of: RO:0002202 UBERON:0000926 ! develops from mesoderm property_value: skos:prefLabel "mixed endoderm/mesoderm-derived structure" xsd:string [Term] id: UBERON:0000078 name: mixed ectoderm/mesoderm/endoderm-derived structure def: "An anatomical structure that develops from the ectoderm, mesoderm and endoderm." [https://orcid.org/0000-0002-6601-2165] subset: grouping_class is_a: UBERON:0000077 ! mixed endoderm/mesoderm-derived structure is_a: UBERON:0004121 ! ectoderm-derived structure intersection_of: UBERON:0000061 ! anatomical structure intersection_of: RO:0002202 UBERON:0000924 ! develops from ectoderm intersection_of: RO:0002202 UBERON:0000925 ! develops from endoderm intersection_of: RO:0002202 UBERON:0000926 ! develops from mesoderm property_value: skos:prefLabel "mixed ectoderm/mesoderm/endoderm-derived structure" xsd:string [Term] id: UBERON:0000079 name: male reproductive system def: "The organs associated with producing offspring in the gender that produces spermatozoa." [MP:0001145] subset: efo_slim subset: human_reference_atlas subset: pheno_slim synonym: "genitalia of male organism" EXACT [OBOL:automatic] synonym: "male genital organ" RELATED [BTO:0000082] synonym: "male genital system" EXACT [FMA:45664] synonym: "male genital tract" RELATED [] synonym: "male genitalia" EXACT [] synonym: "male genitals" EXACT [] synonym: "male organism genitalia" EXACT [OBOL:automatic] synonym: "male organism reproductive system" EXACT [OBOL:automatic] synonym: "male reproductive tract" RELATED [MA:0000396] synonym: "reproductive system of male organism" EXACT [OBOL:automatic] synonym: "systema genitale masculinum" RELATED [BTO:0000082] xref: BTO:0000082 xref: CALOHA:TS-1310 xref: EFO:0000970 xref: EHDAA2:0001054 xref: EHDAA:8136 xref: EMAPA:17968 xref: EV:0100101 xref: FBbt:00004927 {sssom:mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"} xref: FMA:45664 xref: GAID:386 xref: HAO:0000505 xref: MA:0000396 xref: MESH:D005837 xref: NCIT:C12722 xref: SCTID:361340001 xref: TGMA:0000634 xref: UMLS:C0017422 {source="ncithesaurus:Male_Genitalia"} xref: UMLS:C1963704 {source="ncithesaurus:Male_Reproductive_System"} xref: VHOG:0000725 xref: Wikipedia:Male_reproductive_system_(human) xref: XAO:0000155 is_a: UBERON:0000990 ! reproductive system intersection_of: UBERON:0000990 ! reproductive system intersection_of: BFO:0000050 UBERON:0003101 ! part of male organism disjoint_from: UBERON:0000474 ! female reproductive system relationship: BFO:0000050 UBERON:0003101 ! part of male organism property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/prostate-male/v1.2/assets/3d-vh-m-prostate.glb" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0000080 name: mesonephros def: "The second stage of the kidney. It serves as the main excretory organ of aquatic vertebrates and as a temporary embryonic kidney in higher vertebrates. It is composed of the mesonephric duct (also called the Wolffian duct), mesonephric tubules, and associated capillary tufts. A single tubule and its associated capillary tuft is called a mesonephric excretory unit; these units are similar in structure and function to nephrons of the adult kidney. The mesonephros is derived from intermediate mesoderm in the vertebrate embryo." [GO:0001823, Wikipedia:Mesonephros] subset: efo_slim subset: organ_slim subset: pheno_slim subset: vertebrate_core synonym: "amphibian adult kidney" RELATED [XAO:0000141] synonym: "corpus Wolffi" RELATED [BTO:0001542] synonym: "mesonephric kidney" EXACT [XAO:0000141] synonym: "mesonephroi" EXACT OMO:0003004 [http://www.gudmap.org/About/Tutorial/DevMUS.html#DMK_Nephron] synonym: "middle kidney" RELATED [BTO:0001542] synonym: "opisthonephros" RELATED [VHOG:0000038, XAO:0000141] synonym: "opisto nephros" RELATED [] synonym: "opistonephros" RELATED [http://www.usm.maine.edu/bio/courses/bio205/bio205_26_sex.html] synonym: "Wolffian body" EXACT [BTO:0001542, GOC:yaf, MESH:A16.254.500, Wikipedia:Mesonephros] xref: AAO:0010384 xref: BTO:0001542 xref: CALOHA:TS-0624 xref: EFO:0000928 xref: EHDAA2:0001130 xref: EHDAA:1581 xref: EHDAA:5903 xref: EMAPA:16744 xref: FMA:72171 xref: GAID:1308 xref: MESH:D001755 xref: NCIT:C26467 xref: SCTID:308799002 xref: TAO:0000529 xref: UMLS:C0025492 {source="ncithesaurus:Mesonephros"} xref: VHOG:0000038 xref: Wikipedia:Mesonephros xref: XAO:0000141 xref: ZFA:0000529 is_a: UBERON:0002113 ! kidney is_a: UBERON:0004120 ! mesoderm-derived structure relationship: RO:0002202 UBERON:0002120 ! develops from pronephros property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/a/ad/Gray986.png" xsd:anyURI [Term] id: UBERON:0000081 name: metanephros def: "In mammals, the metanephros is the excretory organ of the fetus, which develops into the mature kidney and is formed from the rear portion of the nephrogenic cord. The metanephros is an endocrine and metabolic organ that filters the blood and excretes the end products of body metabolism in the form of urine[GO]." [GO:0001656, Wikipedia:Metanephros#Metanephros] subset: organ_slim subset: pheno_slim synonym: "definite kidney" RELATED [BTO:0001543] synonym: "definitive kidney" RELATED [BTO:0001543] synonym: "hind kidney" RELATED [BTO:0001543] synonym: "metanephric kidney" RELATED [VHOG:0000039] synonym: "metanephron" EXACT [BTO:0001543] xref: BTO:0001543 xref: EHDAA2:0001137 xref: EHDAA:3089 xref: EHDAA:5911 xref: EMAPA:17373 xref: EMAPA_RETIRED:17207 xref: FMA:72172 xref: NCIT:C34209 xref: SCTID:308797000 xref: UMLS:C0231049 {source="ncithesaurus:Metanephros"} xref: VHOG:0000039 xref: Wikipedia:Metanephros#Metanephros is_a: UBERON:0002113 ! kidney is_a: UBERON:0004120 ! mesoderm-derived structure relationship: RO:0002202 UBERON:0003220 {evidence="definitional"} ! develops from metanephric mesenchyme relationship: RO:0002202 UBERON:0005080 {source="GO"} ! develops from metanephric ureteric bud relationship: RO:0002202 UBERON:0005753 ! develops from caudal part of nephrogenic cord relationship: RO:0002285 UBERON:0000080 {source="ISBN:9780878932504"} ! developmentally replaces mesonephros relationship: RO:0002492 UBERON:0000066 ! existence ends during fully formed stage property_value: IAO:0000116 "TODO check developmental relationships" xsd:string [Term] id: UBERON:0000083 name: mesonephric tubule def: "A mesonephric tubule is an epithelial tube that is part of the mesonephros[GO]. Genital ridge that is next to the mesonephros[WP]." [Wikipedia:Mesonephric_tubules] synonym: "renal tubules" RELATED OMO:0003004 [VHOG:0000500] synonym: "tubuli mesonephrici" RELATED OMO:0003011 [Wikipedia:Mesonephric_tubules] xref: AAO:0010389 xref: EHDAA2:0001134 xref: EMAPA:16747 xref: VHOG:0000500 xref: Wikipedia:Mesonephric_tubules xref: XAO:0000148 is_a: UBERON:0003914 ! epithelial tube is_a: UBERON:0005103 ! mesonephric epithelium is_a: UBERON:0006555 ! excretory tube intersection_of: UBERON:0003914 ! epithelial tube intersection_of: BFO:0000050 UBERON:0000080 ! part of mesonephros property_value: IAO:0000116 "TODO check" xsd:string [Term] id: UBERON:0000084 name: ureteric bud def: "An epithelial swelling on the Wolffian duct that elongates to invade the adjacent metanephric mesenchyme[MP]." [MP:0010979, PMID:19828308] subset: pheno_slim synonym: "diverticulum" RELATED [BTO:0001646] synonym: "diverticulum metanephricum" RELATED OMO:0003011 [Wikipedia:Ureteric_bud] synonym: "gemma ureterica" RELATED OMO:0003011 [Wikipedia:Ureteric_bud] synonym: "metanephric bud" RELATED [BTO:0001646] synonym: "metanephric diverticulum" RELATED [Wikipedia:Metanephros#Metanephros] synonym: "ureteric ampulla" RELATED [] synonym: "ureteric diverticulum" RELATED [VHOG:0000541] xref: BTO:0001646 xref: EHDAA2:0002140 xref: EHDAA:3091 xref: EHDAA:5917 xref: EMAPA:17209 xref: NCIT:C34207 xref: SCTID:361528000 xref: UMLS:C1284058 {source="ncithesaurus:Metanephric_Diverticulum"} xref: VHOG:0000541 xref: Wikipedia:Ureteric_bud is_a: UBERON:0000083 ! mesonephric tubule is_a: UBERON:0007499 {source="EHDAA2"} ! epithelial sac is_a: UBERON:0012275 ! meso-epithelium is_a: UBERON:0034969 ! epithelial layer of duct relationship: BFO:0000050 UBERON:0003074 ! part of mesonephric duct relationship: RO:0002202 UBERON:0003074 {source="EHDAA2"} ! develops from mesonephric duct relationship: RO:0002256 UBERON:0003220 {source="ISBN:9780878932504"} ! developmentally induced by metanephric mesenchyme [Term] id: UBERON:0000085 name: morula def: "A spherical embryonic mass of blastomeres formed before the blastula and resulting from cleavage of the fertilized ovum." [MP:0012130] subset: pheno_slim synonym: "morula (2-16 cells)" RELATED [EHDAA2:0000005] xref: BTO:0001508 xref: EHDAA2:0000005 xref: FMA:292334 xref: GAID:1295 xref: MESH:D009028 xref: NCIT:C34212 xref: SCTID:361474003 xref: UMLS:C0026573 {source="ncithesaurus:Morula"} xref: Wikipedia:Morula is_a: UBERON:0000922 ! embryo relationship: BFO:0000050 UBERON:0004716 {source="EHDAA2"} ! part of conceptus relationship: BFO:0000051 CL:0000353 ! has part blastoderm cell relationship: RO:0002219 UBERON:0000086 ! surrounded by zona pellucida relationship: RO:0002488 UBERON:0000107 ! existence starts during cleavage stage relationship: RO:0002492 UBERON:0000107 ! existence ends during cleavage stage property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/c/c6/Blastulation.png" xsd:anyURI property_value: skos:prefLabel "morula" xsd:string [Term] id: UBERON:0000086 name: zona pellucida def: "A glycoprotein membrane surrounding the plasma membrane of an oocyte. It is a vital constitutive part of the latter, external but not extraneous to it. The zona pellucida first appears in multilaminar primary oocytes." [Wikipedia:Zona_pellucida] subset: human_reference_atlas subset: pheno_slim subset: vertebrate_core synonym: "oolemma" RELATED [BTO:0003135] synonym: "pellucid zone" RELATED [BTO:0003135] synonym: "striated membrane" RELATED [BTO:0003135] synonym: "vitelline envelope" RELATED [] synonym: "vitelline membrane" RELATED [] synonym: "zona pellucida - vitelline membrane" BROAD [VHOG:0000720] synonym: "zona radiata" RELATED [BTO:0003135] synonym: "zona striata" RELATED [BTO:0003135] xref: BTO:0003135 xref: EHDAA2:0002220 xref: EHDAA:31 xref: EHDAA:62 xref: EMAPA:16035 xref: FMA:18674 xref: GAID:410 xref: MA:0001715 xref: MESH:D015044 xref: NCIT:C33896 xref: TAO:0001111 xref: UMLS:C0043519 {source="ncithesaurus:Zona_Pellucida"} xref: Wikipedia:Zona_pellucida xref: ZFA:0001111 is_a: UBERON:0005764 ! acellular membrane relationship: BFO:0000050 UBERON:0000992 ! part of ovary relationship: BFO:0000051 CHEBI:17089 ! has part relationship: RO:0002007 CL:0000023 ! bounding layer of oocyte property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/8/81/Gray3.png" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "zona pellucida" xsd:string [Term] id: UBERON:0000087 name: inner cell mass def: "A mass of cells that develop into the body of the embryo and some extraembryonic tissues." [ISBN:0-683-40008-8, MGI:pvb] subset: early_development subset: efo_slim subset: pheno_slim synonym: "early embryoblast" RELATED [FMA:86557] synonym: "embryoblast" RELATED [] synonym: "embryoblastus; massa cellularis interna; pluriblastus senior" RELATED OMO:0003011 [Wikipedia:Inner_cell_mass] synonym: "ICM" RELATED [VHOG:0000742] synonym: "pluriblast" RELATED [] xref: EFO:0000547 xref: EHDAA2:0000830 xref: EHDAA:40 xref: EMAPA:16041 xref: FMA:86557 xref: NCIT:C13740 xref: SCTID:361456007 xref: UMLS:C1283994 {source="ncithesaurus:Inner_Cell_Mass"} xref: VHOG:0000742 xref: Wikipedia:Inner_cell_mass is_a: BFO:0000002 is_a: UBERON:0002050 ! embryonic structure relationship: RO:0002202 UBERON:0000358 {source="Wikipedia"} ! develops from blastocyst relationship: RO:0002219 UBERON:0000088 {source="Wikipedia"} ! surrounded by trophoblast property_value: foaf:depiction "https://upload.wikimedia.org/wikipedia/commons/7/72/Blastocyst_English.svg" xsd:anyURI property_value: skos:prefLabel "inner cell mass" xsd:string [Term] id: UBERON:0000088 name: trophoblast def: "The mesectodermal cell layer arising from the trophectoderm that erodes the uterine mucosa and contributes to the formation of the placenta." [ISBN:0-683-40008-8, MP:0005031] comment: Aggregate of cells forming the outer layer of a blastocyst, which provide nutrients to the embryo and develop into a large part of the placenta. They are formed during the first stage of pregnancy and are the first cells to differentiate from the fertilized egg. [Wikipedia:Trophoblast] subset: early_development subset: pheno_slim synonym: "massa cellularis externa" RELATED OMO:0003011 [Wikipedia:Trophoblast] synonym: "trophoblast layer" EXACT [MP:0005031] synonym: "trophoblastus" RELATED OMO:0003011 [Wikipedia:Trophoblast] synonym: "trophoderm" RELATED [BTO:0001079] xref: BTO:0001079 xref: CALOHA:TS-1070 xref: EV:0100120 xref: FMA:83029 xref: GAID:1152 xref: MESH:D014327 xref: NCIT:C93292 xref: SCTID:362839005 xref: UMLS:C0041178 {source="ncithesaurus:Trophoblast"} xref: Wikipedia:Trophoblast is_a: BFO:0000002 is_a: UBERON:0002050 ! embryonic structure relationship: BFO:0000050 UBERON:0000358 ! part of blastocyst relationship: RO:0002202 UBERON:0004345 {source="MP-def", source="PMID:19829370"} ! develops from trophectoderm relationship: RO:0002473 CL:0000351 ! composed primarily of trophoblast cell property_value: foaf:depiction "https://upload.wikimedia.org/wikipedia/commons/7/72/Blastocyst_English.svg" xsd:anyURI property_value: skos:prefLabel "trophoblast" xsd:string [Term] id: UBERON:0000091 name: bilaminar disc def: "A flattened, almost circular bilaminar plate of cells formed when the inner cell mass (aka embryoblast) forms two epithelial layers, each of a distinct lineage, separated by an extracellular basement membrane: the external (dorsal) layer is called the epiblast and the internal (ventral) layer is called the hypoblast (aka primitive endoderm); together, they compose the bilaminar embryonic disc." [MP:0003886] subset: early_development subset: pheno_slim synonym: "bilaminar disk" RELATED [Wikipedia:Bilaminar_disc] synonym: "bilaminary embryonic disc" EXACT [] synonym: "bilaminary germ disc" EXACT [ISBN:9780878932504] synonym: "embryonic disc" BROAD [MP:0003886] synonym: "embryonic shield" BROAD [MP:0003886] synonym: "germinal disc" BROAD [MP:0003886] synonym: "germinal disk" BROAD [MP:0003886] xref: FMA:293863 xref: NCIT:C34112 xref: UMLS:C1283997 {source="ncithesaurus:Bilaminar_Embryonic_Disc"} xref: Wikipedia:Bilaminar_disc is_a: BFO:0000002 is_a: UBERON:0002050 ! embryonic structure relationship: RO:0002202 UBERON:0000087 {source="Wikipedia"} ! develops from inner cell mass property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/e/e3/Gray21.png" xsd:anyURI property_value: skos:prefLabel "bilaminar disc" xsd:string [Term] id: UBERON:0000092 name: post-embryonic stage def: "Stage succeeding embryo, including mature structure." [https://orcid.org/0000-0002-6601-2165] synonym: "post-hatching stage" NARROW [] synonym: "postembryonic" RELATED [] synonym: "postembryonic stage" EXACT [] xref: BilaDO:0000003 xref: OGES:000010 xref: OGES:000014 xref: OGES:000024 xref: SsalDv:0000038 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: WBls:0000022 xref: WBls:0000093 xref: WBls:0000103 is_a: BFO:0000003 is_a: UBERON:0000105 ! life cycle stage relationship: BFO:0000062 UBERON:0000068 ! preceded by embryo stage relationship: RO:0002082 GO:0009791 ! simultaneous with post-embryonic development property_value: seeAlso "https://github.com/obophenotype/uberon/issues/344" xsd:anyURI property_value: skos:prefLabel "post-embryonic stage" xsd:string [Term] id: UBERON:0000093 name: sulcus def: "A depression or fissure in the surface of an organ." [Wikipedia:Sulcus_(anatomy)] subset: grouping_class subset: non_informative xref: Wikipedia:Sulcus_(anatomy) is_a: UBERON:0000464 ! anatomical space property_value: skos:prefLabel "sulcus" xsd:string property_value: terms:contributor https://orcid.org/0000-0002-6601-2165 creation_date: 2009-04-09T06:23:22Z [Term] id: UBERON:0000094 name: membrane organ def: "Nonparenchymatous organ that primarily consists of dense connective tissue organized into a sheet which interconnects two or more organs, separates two or more body spaces from one another, or surrounds an organ or body part. Examples: interosseous membrane of forearm, obturator membrane, tympanic membrane, fibrous pericardium, fascia lata, dura mater. [FMA]." [FMA:7145] synonym: "membrane" BROAD [] synonym: "membrane of organ" EXACT [] xref: FMA:7145 is_a: UBERON:0000062 ! organ relationship: RO:0002473 UBERON:0011823 {source="FMA-def"} ! composed primarily of dense connective tissue property_value: skos:prefLabel "membrane organ" xsd:string property_value: terms:contributor https://orcid.org/0000-0002-6601-2165 creation_date: 2009-07-30T05:19:13Z [Term] id: UBERON:0000095 name: cardiac neural crest def: "Portion of neural crest that develops from the dorsal neural tube. It overlaps the vagal neural crest and migrates to populate the pharyngeal arches 3, 4 and 6 (producing structures in the head) and to the heart, forming connective tissue that separates the great vessels of the heart. [Wikipedia]." [Wikipedia:Cardiac_neural_crest] subset: vertebrate_core synonym: "cardiac neural crest complex" RELATED [Wikipedia:Cardiac_neural_crest] synonym: "complexus cristae neuralis cardiacus" RELATED [Wikipedia:Cardiac_neural_crest] xref: TAO:0002173 xref: Wikipedia:Cardiac_neural_crest xref: XAO:0004190 xref: ZFA:0001648 is_a: UBERON:0005291 ! embryonic tissue relationship: BFO:0000050 UBERON:0002342 ! part of neural crest relationship: RO:0002131 UBERON:0005428 {source="Wikipedia"} ! overlaps vagal neural crest property_value: skos:prefLabel "cardiac neural crest" xsd:string property_value: terms:contributor https://orcid.org/0000-0002-6601-2165 creation_date: 2009-07-30T07:57:38Z [Term] id: UBERON:0000101 name: lobe of lung def: "A lung lobe is one of the rounded projections that compose the lung[GO]." [GOC:GO] subset: pheno_slim synonym: "lung lobe" EXACT [] synonym: "pulminory lobe" EXACT [] synonym: "pulmonary lobe" EXACT [FMA:7311] xref: EMAPA:36281 xref: FMA:7311 xref: galen:LobeOfLung xref: MA:0003098 xref: NCIT:C34021 xref: SCTID:245524004 xref: UMLS:C0225752 {source="ncithesaurus:Lung_Lobe"} is_a: UBERON:0009912 {source="FMA"} ! anatomical lobe relationship: BFO:0000050 UBERON:0002048 ! part of lung relationship: RO:0002433 UBERON:0002048 ! contributes to morphology of lung property_value: skos:prefLabel "lobe of lung" xsd:string [Term] id: UBERON:0000102 name: lung vasculature def: "The lung vasculature is composed of the tubule structures that carry blood or lymph in the lungs[GO]." [GOC:GO] subset: pheno_slim synonym: "lung vascular network" EXACT [OBOL:automatic] synonym: "pulmonary vasculature" EXACT [FMA:73750] synonym: "vascular network of lung" EXACT [OBOL:automatic] synonym: "vasculature of lung" EXACT [OBOL:automatic] xref: FMA:73750 is_a: UBERON:0002201 ! vasculature of trunk is_a: UBERON:0006876 ! vasculature of organ intersection_of: UBERON:0002049 ! vasculature intersection_of: BFO:0000050 UBERON:0002048 ! part of lung relationship: BFO:0000050 UBERON:0002048 ! part of lung property_value: skos:prefLabel "lung vasculature" xsd:string [Term] id: UBERON:0000104 name: life cycle def: "An entire span of an organism's life. In metazoans, commences with the zygote stage and ends with the death of the organism." [https://orcid.org/0000-0002-6601-2165] subset: common_anatomy subset: upper_level synonym: "entire life cycle" EXACT [] synonym: "entire lifespan" EXACT [] synonym: "life" EXACT [] synonym: "lifespan" EXACT [] xref: AcarDv:0000001 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: BtauDv:0000001 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: CfamDv:0000001 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: ChirDv:0000001 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: CporDv:0000001 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: DpseDv:0000001 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: DsimDv:0000001 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: EcabDv:0000001 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: FBdv:00000000 xref: FcatDv:0000001 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: GgalDv:0000001 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: GgorDv:0000001 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: HsapDv:0000001 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: MdomDv:0000001 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: MmulDv:0000001 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: MmusDv:0000001 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: ncithesaurus:Life xref: OanaDv:0000001 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: OariDv:0000001 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: OcunDv:0000001 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: OGES:000011 xref: PpanDv:0000001 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: PtroDv:0000001 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: RnorDv:0000001 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: SsalDv:0000001 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: SscrDv:0000001 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: BFO:0000003 is_a: UBERON:0000000 ! processual entity relationship: RO:0002230 UBERON:0000071 ! ends with death stage property_value: RO:0002175 NCBITaxon:33090 property_value: RO:0002175 NCBITaxon:33208 property_value: RO:0002175 NCBITaxon:4751 property_value: seeAlso "https://github.com/obophenotype/uberon/issues/532" xsd:anyURI property_value: skos:prefLabel "life cycle" xsd:string [Term] id: UBERON:0000105 name: life cycle stage def: "A spatiotemporal region encompassing some part of the life cycle of an organism." [https://orcid.org/0000-0002-6601-2165] subset: common_anatomy subset: efo_slim subset: upper_level synonym: "developmental stage" NARROW [] synonym: "stage" NARROW [] xref: AcarDv:0000000 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: BILS:0000105 xref: BtauDv:0000000 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: CfamDv:0000000 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: ChirDv:0000000 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: CporDv:0000000 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: DpseDv:0000000 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: DsimDv:0000000 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: EcabDv:0000000 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: EFO:0000399 xref: FBdv:00007012 xref: FcatDv:0000000 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: FMA:24120 xref: GgalDv:0000000 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: GgorDv:0000000 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: HsapDv:0000000 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: MdomDv:0000000 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: MESH:D008018 xref: MmulDv:0000000 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: MmusDv:0000000 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: ncithesaurus:Developmental_Stage xref: OanaDv:0000000 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: OariDv:0000000 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: OcunDv:0000000 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: PdumDv:0000090 xref: PpanDv:0000000 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: PtroDv:0000000 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: RnorDv:0000000 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: SsalDv:0000000 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: SscrDv:0000000 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: WBls:0000002 xref: XAO:1000000 xref: ZFS:0000000 xref: ZFS:0100000 is_a: UBERON:0000000 ! processual entity relationship: BFO:0000050 UBERON:0000104 ! part of life cycle property_value: IAO:0000116 "this class represents a proper part of the life cycle of an organism. The class 'life cycle' should not be placed here" xsd:string property_value: RO:0002175 NCBITaxon:33090 property_value: RO:0002175 NCBITaxon:33208 property_value: RO:0002175 NCBITaxon:4751 property_value: skos:prefLabel "life cycle stage" xsd:string [Term] id: UBERON:0000106 name: zygote stage def: "A stage at which the organism is a single cell produced by means of sexual reproduction." [Wikipedia:Zygote] subset: efo_slim synonym: "1-cell stage" EXACT [] synonym: "fertilized egg stage" EXACT [BTO:0000854] synonym: "fertilized egg stage" RELATED [] synonym: "one cell stage" EXACT [] synonym: "one-cell stage" RELATED [VHOG:0000745] synonym: "zygote" RELATED [VHOG:0000745] synonym: "zygotum" RELATED OMO:0003011 [Wikipedia:Zygote] xref: BilaDO:0000005 xref: BILS:0000106 xref: ChirDv:0000003 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: EFO:0001322 xref: EHDAA:27 xref: FBdv:00005288 xref: HsapDv:0000003 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: MmusDv:0000003 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: NCIT:C12601 xref: OariDv:0000009 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: PdumDv:0000100 xref: RnorDv:0000048 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: SsalDv:0000003 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: SscrDv:0000087 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: VHOG:0000745 xref: Wikipedia:Zygote xref: XAO:1000001 xref: ZFS:0000001 is_a: BFO:0000003 is_a: UBERON:0000105 ! life cycle stage relationship: BFO:0000050 UBERON:0000068 ! part of embryo stage relationship: RO:0002223 UBERON:0000104 ! starts life cycle property_value: seeAlso EMAPA:16033 property_value: skos:prefLabel "zygote stage" xsd:string [Term] id: UBERON:0000107 name: cleavage stage def: "The first few specialized divisions of an activated animal egg; Stage consisting of division of cells in the early embryo. The zygotes of many species undergo rapid cell cycles with no significant growth, producing a cluster of cells the same size as the original zygote. The different cells derived from cleavage are called blastomeres and form a compact mass called the morula. Cleavage ends with the formation of the blastula." [GO:0040016, Wikipedia:Cleavage_(embryo)] subset: efo_slim xref: BilaDO:0000006 xref: BILS:0000107 xref: ChirDv:0000004 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: EFO:0001290 xref: FBdv:00000054 xref: GgalDv:0000064 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: HsapDv:0000005 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: MESH:D002970 xref: MmusDv:0000004 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: OariDv:0000010 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: OGES:000015 xref: OGES:000020 xref: PdumDv:0000200 xref: RnorDv:0000049 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: SsalDv:0000004 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: SscrDv:0000088 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: Wikipedia:Cleavage_(embryo) xref: XAO:1000004 xref: ZFS:0000046 is_a: BFO:0000003 is_a: UBERON:0000105 ! life cycle stage intersection_of: UBERON:0000105 ! life cycle stage intersection_of: RO:0002082 GO:0040016 ! simultaneous with embryonic cleavage relationship: BFO:0000050 UBERON:0000068 ! part of embryo stage relationship: RO:0002082 GO:0040016 ! simultaneous with embryonic cleavage relationship: RO:0002087 UBERON:0000106 ! immediately preceded by zygote stage property_value: skos:prefLabel "cleavage stage" xsd:string [Term] id: UBERON:0000108 name: blastula stage def: "An early stage of embryonic development in animals. It is produced by cleavage of a fertilized ovum and consists of a spherical layer of around 128 cells surrounding a central fluid-filled cavity called the blastocoel. The blastula follows the morula and precedes the gastrula in the developmental sequence." [Wikipedia:Blastula] subset: efo_slim xref: BilaDO:0000007 xref: BILS:0000108 xref: ChirDv:0000010 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: EFO:0001282 xref: GgalDv:0000091 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: HsapDv:0000006 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: MmusDv:0000007 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: OariDv:0000025 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: OGES:000003 xref: OGES:000016 xref: OGES:000021 xref: RnorDv:0000054 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: SsalDv:0000012 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: SscrDv:0000089 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: WBls:0000005 xref: Wikipedia:Blastula xref: XAO:1000003 xref: ZFS:0000045 is_a: BFO:0000003 is_a: UBERON:0000105 ! life cycle stage relationship: BFO:0000050 UBERON:0000068 ! part of embryo stage relationship: BFO:0000062 UBERON:0000107 ! preceded by cleavage stage property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/c/c6/Blastulation.png" xsd:anyURI property_value: IAO:0000116 "consider adding a preceding stage 'morula stage' as part of cleavage" xsd:string property_value: skos:prefLabel "blastula stage" xsd:string [Term] id: UBERON:0000109 name: gastrula stage def: "A stage defined by complex and coordinated series of cellular movements that occurs at the end of cleavage during embryonic development of most animals. The details of gastrulation vary from species to species, but usually result in the formation of the three primary germ layers, ectoderm, mesoderm and endoderm." [GO:0007369] subset: efo_slim synonym: "blastocystis trilaminaris stage" RELATED [https://orcid.org/0000-0002-6601-2165] synonym: "trilaminar blastocyst stage" RELATED [https://orcid.org/0000-0002-6601-2165] synonym: "trilaminar blastoderm stage" RELATED [https://orcid.org/0000-0002-6601-2165] synonym: "trilaminar disk stage" RELATED [https://orcid.org/0000-0002-6601-2165] synonym: "trilaminar germ stage" RELATED [https://orcid.org/0000-0002-6601-2165] synonym: "trilaminar stage" RELATED [https://orcid.org/0000-0002-6601-2165] xref: BilaDO:0000008 xref: BILS:0000109 xref: ChirDv:0000011 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: EFO:0001296 xref: FBdv:00005317 xref: GgalDv:0000092 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: HsapDv:0000010 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: MmusDv:0000013 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: OariDv:0000026 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: OGES:000004 xref: OGES:000019 xref: RnorDv:0000005 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: SsalDv:0000016 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: SscrDv:0000090 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: WBls:0000010 xref: XAO:1000005 xref: ZFS:0000047 is_a: BFO:0000003 is_a: UBERON:0000105 ! life cycle stage relationship: BFO:0000050 UBERON:0000068 ! part of embryo stage relationship: BFO:0000062 UBERON:0000108 {source="BILS"} ! preceded by blastula stage relationship: RO:0002082 GO:0007369 ! simultaneous with gastrulation relationship: RO:0002162 NCBITaxon:6072 ! in taxon Eumetazoa property_value: skos:prefLabel "gastrula stage" xsd:string [Term] id: UBERON:0000110 name: neurula stage def: "A chordate developmental stage defined by the formation of a tube from the flat layer of ectodermal cells known as the neural plate. This will give rise to the central nervous system." [GO:0001841] xref: BilaDO:0000009 xref: BILS:0000110 xref: ChirDv:0000012 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: GgalDv:0000093 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: HsapDv:0000012 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: MmusDv:0000017 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: OariDv:0000027 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: RnorDv:0000007 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: SscrDv:0000091 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: XAO:1000006 is_a: BFO:0000003 is_a: UBERON:0000105 ! life cycle stage relationship: BFO:0000050 UBERON:0000068 ! part of embryo stage relationship: BFO:0000062 UBERON:0000109 ! preceded by gastrula stage relationship: RO:0002082 GO:0001841 ! simultaneous with neural tube formation relationship: RO:0002162 NCBITaxon:7711 ! in taxon Chordata property_value: seeAlso "https://github.com/obophenotype/developmental-stage-ontologies/issues/84" xsd:anyURI property_value: seeAlso "https://github.com/obophenotype/uberon/issues/343" xsd:anyURI property_value: skos:prefLabel "neurula stage" xsd:string [Term] id: UBERON:0000111 name: organogenesis stage def: "A stage at which the ectoderm, endoderm, and mesoderm develop into the internal organs of the organism." [Wikipedia:Organogenesis] synonym: "segmentation stage" RELATED [] xref: BilaDO:0000010 xref: BILS:0000111 xref: ChirDv:0000013 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: GgalDv:0000094 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: HsapDv:0000015 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: MmusDv:0000018 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: OariDv:0000028 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: OGES:000005 xref: OGES:000032 xref: RnorDv:0000055 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: SsalDv:0000022 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: SscrDv:0000086 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: Wikipedia:Organogenesis is_a: BFO:0000003 is_a: UBERON:0000105 ! life cycle stage relationship: BFO:0000050 UBERON:0000068 ! part of embryo stage relationship: RO:0002082 GO:0048513 ! simultaneous with animal organ development relationship: RO:0002162 NCBITaxon:6072 ! in taxon Eumetazoa property_value: seeAlso "https://github.com/obophenotype/developmental-stage-ontologies/issues/84" xsd:anyURI property_value: seeAlso "https://github.com/obophenotype/uberon/issues/533" xsd:anyURI property_value: skos:prefLabel "organogenesis stage" xsd:string [Term] id: UBERON:0000112 name: sexually immature stage subset: efo_slim synonym: "immature stage" EXACT [VHOG:FB] synonym: "juvenile stage" NARROW [XAO:1000010] synonym: "subadult stage" RELATED [http://eol.org/schema/terms/subadult] xref: AcarDv:0000003 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: BILS:0000112 xref: BtauDv:0000003 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: BTO:0002168 xref: CfamDv:0000003 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: ChirDv:0000015 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: CporDv:0000003 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: EcabDv:0000003 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: EFO:0001300 xref: EV:0300051 xref: FcatDv:0000003 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: GgalDv:0000003 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: GgorDv:0000003 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: HsapDv:0000264 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: MdomDv:0000003 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: MmulDv:0000003 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: MmusDv:0000043 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: OanaDv:0000003 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: OariDv:0000003 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: OcunDv:0000003 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: OGES:000009 xref: PpanDv:0000003 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: PtroDv:0000003 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: RnorDv:0000012 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: SsalDv:0000041 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: SscrDv:0000003 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: XAO:1000010 xref: XtroDO:0000083 xref: ZFS:0000051 is_a: BFO:0000003 is_a: UBERON:0000105 ! life cycle stage relationship: BFO:0000050 UBERON:0000066 ! part of fully formed stage property_value: seeAlso "https://github.com/obophenotype/uberon/issues/427" xsd:anyURI [Term] id: UBERON:0000113 name: post-juvenile adult stage def: "The stage of being a sexually mature adult animal." [https://orcid.org/0000-0002-6601-2165] synonym: "adult stage" BROAD [] xref: AcarDv:0000004 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: BILS:0000113 xref: BtauDv:0000004 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: CfamDv:0000004 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: ChirDv:0000035 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: CporDv:0000004 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: EcabDv:0000004 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: EV:0300064 xref: EV:0300070 xref: FcatDv:0000004 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: GgalDv:0000006 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: GgorDv:0000006 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: HsapDv:0000258 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: MdomDv:0000006 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: MIAA:0000403 xref: MmulDv:0000021 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: MmusDv:0000110 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: OanaDv:0000004 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: OariDv:0000006 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: OcunDv:0000004 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: OGES:000026 xref: OGES:000027 xref: PpanDv:0000016 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: PtroDv:0000011 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: RnorDv:0000015 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: SsalDv:0000042 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: SscrDv:0000006 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: XAO:1000093 xref: ZFS:0000044 is_a: BFO:0000003 is_a: UBERON:0000105 ! life cycle stage relationship: BFO:0000050 UBERON:0000066 ! part of fully formed stage relationship: BFO:0000062 UBERON:0000112 ! preceded by sexually immature stage property_value: seeAlso "https://github.com/obophenotype/uberon/issues/345" xsd:anyURI property_value: seeAlso "https://github.com/obophenotype/uberon/issues/499" xsd:anyURI [Term] id: UBERON:0000114 name: lung connective tissue def: "The connective tissue located between the respiratory (airway and alveolar) epithelium, the capillary endothelium and pleural mesothelium; it contains basement membrane composed of collagen, elastin, proteoglycans, and fibronectin." [ISBN:0-683-40008-8, MGI:anna, MP:0002276, PMID:14635660] subset: human_reference_atlas subset: pheno_slim synonym: "connective tissue of lung" EXACT [OBOL:automatic] synonym: "lung interstitial tissue" RELATED [MA:0001782] synonym: "lung interstitium" RELATED [] synonym: "pulmonary connective tissue" RELATED [EMAPA:35521] synonym: "pulmonary interstitial tissue" RELATED [] synonym: "pulmonary interstitium" EXACT [FMA:27533] xref: EMAPA:35521 xref: FMA:27533 xref: MA:0001782 xref: SCTID:201609008 is_a: UBERON:0003580 ! lower respiratory tract connective tissue is_a: UBERON:0003837 ! thoracic segment connective tissue is_a: UBERON:0004120 ! mesoderm-derived structure intersection_of: UBERON:0002384 ! connective tissue intersection_of: BFO:0000050 UBERON:0002048 ! part of lung relationship: BFO:0000050 UBERON:0002048 ! part of lung relationship: RO:0002433 UBERON:0002048 ! contributes to morphology of lung relationship: RO:0002494 UBERON:0004883 ! transformation of lung mesenchyme property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "lung connective tissue" xsd:string [Term] id: UBERON:0000115 name: lung epithelium def: "The epithelial layer of the lung." [MP:0006382] subset: pheno_slim synonym: "epithelial tissue of lung" EXACT [OBOL:automatic] synonym: "epithelium of lung" EXACT [OBOL:automatic] synonym: "lung epithelial tissue" EXACT [OBOL:automatic] synonym: "pulmonary epithelium" RELATED [BTO:0001653] xref: BTO:0001653 xref: EMAPA:32860 xref: MA:0001783 is_a: BFO:0000002 is_a: UBERON:0004815 ! lower respiratory tract epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: BFO:0000050 UBERON:0002048 ! part of lung relationship: BFO:0000050 UBERON:0002048 ! part of lung relationship: RO:0002202 UBERON:0001041 ! develops from foregut relationship: RO:0002433 UBERON:0002048 ! contributes to morphology of lung property_value: skos:prefLabel "lung epithelium" xsd:string [Term] id: UBERON:0000117 name: respiratory tube def: "A tube in the respiratory system. Examples: bronchus, bronchiole, trachea." [GO:0030323, http://orcid.org/0000-0002-6601-2165] synonym: "airway" RELATED [] synonym: "respiratory conducting tube" NARROW [MP:0004391] synonym: "segment of tracheobronchial tree" EXACT [FMA:12224] synonym: "segment of tracheobronchial tree" NARROW [FMA:12224] synonym: "tracheobronchial tree segment" NARROW [FMA:12224] xref: EMAPA:37946 {source="MA:th"} xref: FMA:12224 is_a: UBERON:0000025 ! tube intersection_of: UBERON:0000025 ! tube intersection_of: BFO:0000050 UBERON:0000065 ! part of respiratory tract relationship: BFO:0000050 UBERON:0000065 ! part of respiratory tract relationship: BFO:0000051 UBERON:0000483 ! has part epithelium property_value: skos:prefLabel "respiratory tube" xsd:string [Term] id: UBERON:0000118 name: lung bud def: "Structure derived from foregut that becomes a lung[GO]." [GO:0060431, Wikipedia:Respiratory_bud] subset: pheno_slim synonym: "gemma pulmonalis" RELATED OMO:0003011 [Wikipedia:Lung_buds] synonym: "gemma respiratoria" RELATED OMO:0003011 [Wikipedia:Lung_buds] synonym: "lung bud" RELATED OMO:0003004 [] synonym: "primary lung bud" RELATED [GO:0060572] synonym: "respiratory diverticulum" RELATED [Wikipedia:Lung_buds] xref: BTO:0001643 xref: EHDAA2:0004089 xref: NCIT:C34260 xref: NCIT:C34282 xref: SCTID:361427007 xref: UMLS:C1514420 {source="ncithesaurus:Primary_Bronchial_Bud"} xref: UMLS:C1514897 {source="ncithesaurus:Respiratory_Diverticulum"} xref: Wikipedia:Respiratory_bud is_a: BFO:0000002 is_a: UBERON:0005153 {source="GO:0060441"} ! epithelial bud relationship: RO:0002202 UBERON:0005597 ! develops from lung primordium relationship: RO:0002202 UBERON:0008947 {source="EHDAA2"} ! develops from respiratory primordium relationship: RO:0002220 UBERON:0004872 ! adjacent to splanchnic layer of lateral plate mesoderm property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/7/71/Gray948.png" xsd:anyURI property_value: IAO:0000116 "clarify successors - include bronchi?" xsd:string property_value: skos:prefLabel "lung bud" xsd:string [Term] id: UBERON:0000119 name: cell layer def: "Portion of tissue, that consists of single layer of cells connected to each other by cell junctions. Examples: layer of glial cells; epithelium." [https://orcid.org/0000-0002-6601-2165] subset: upper_level synonym: "cell sheath" RELATED [] synonym: "layer" BROAD [NCIT:C66831] synonym: "layer of cells" EXACT [] synonym: "sheath of cells" RELATED [] xref: NCIT:C66831 is_a: UBERON:0000957 ! lamina property_value: IAO:0000116 "consider adding to caro" xsd:string property_value: skos:prefLabel "cell layer" xsd:string [Term] id: UBERON:0000120 name: blood brain barrier def: "Cell layer consisting of lining cells that separates the central nervous system and the bloodstream. The BBB may consist of endothelial cells or glial cells. An endothelial barrier may have arisen independently several times during evolution. In bichir and lungfish the barrier is formed by brain endothelial cells, while in sturgeon it is formed by a complex perivascular glial sheath, but with no detectable tight junctions." [DOI:10.1002/glia.20642, Wikipedia:Blood-brain_barrier] synonym: "BBB" RELATED [] synonym: "blood-brain barrier" EXACT [] xref: http://uri.neuinfo.org/nif/nifstd/nlx_subcell_100205 xref: NCIT:C13194 xref: UMLS:C0005854 {source="ncithesaurus:Blood-Brain_Barrier"} xref: Wikipedia:Blood-brain_barrier is_a: UBERON:0000119 ! cell layer relationship: BFO:0000050 UBERON:0001016 ! part of nervous system relationship: RO:0002220 UBERON:0000179 ! adjacent to haemolymphatic fluid relationship: RO:0002220 UBERON:0000955 ! adjacent to brain property_value: skos:prefLabel "blood brain barrier" xsd:string [Term] id: UBERON:0000121 name: perineurium def: "A layer of thin, concentrically arranged cells with interspersed collagen that lies within the epineurium. The perineurium is a component of the blood–nerve barrier and is essential for protecting axons and their associated Schwann cells from ionic flux, toxins and infection." [NLXANAT:090205, PMID:18434767, PMID:25818566] xref: BTO:0003153 xref: EMAPA:37849 {source="MA:th"} xref: FMA:52585 xref: NCIT:C33302 xref: NCIT:C41407 xref: NLXANAT:090205 xref: SCTID:362299001 xref: UMLS:C0205890 {source="ncithesaurus:Perineurium"} xref: Wikipedia:Perineurium is_a: UBERON:0011822 {source="FMA"} ! dense irregular connective tissue relationship: BFO:0000050 UBERON:0003209 ! part of blood nerve barrier relationship: RO:0001025 UBERON:0000124 ! located in epineurium relationship: RO:0002007 UBERON:0001019 ! bounding layer of nerve fasciculus property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/9/9c/Gray636.png" xsd:anyURI [Term] id: UBERON:0000122 name: neuron projection bundle def: "A fasciculated bundle of neuron projections (GO:0043005), largely or completely lacking synapses." [CARO:0001001, FBbt:00005099, FBC:DOS] synonym: "funiculus" EXACT [] synonym: "nerve fiber bundle" EXACT [FBbt:00005099] synonym: "neural fiber bundle" EXACT [] xref: CARO:0001001 xref: FBbt:00005099 {sssom:mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"} xref: NLX:147821 is_a: UBERON:0005162 ! multi cell part structure relationship: BFO:0000050 UBERON:0001016 ! part of nervous system relationship: BFO:0000051 GO:0043005 ! has part neuron projection property_value: skos:prefLabel "neuron projection bundle" xsd:string [Term] id: UBERON:0000124 name: epineurium def: "A loose connective tissue sheath surrounding each peripheral nerve. Composed mainly of colagen and fibroblasts, it forms a substantial covering over nerve trunks, then thins to an incomplete layer around smaller branches near their terminations. The epineurium is continuous centrally with the dura. Peripherally, it usually ends near the termination of a nerve fiber, but it may continue as the capsule of Meissner corpuscles and a few other encapsulated endings. Nolte, J. The Human Brain 3rd edition." [NLXANAT:090203] xref: BTO:0003154 xref: EMAPA:37848 {source="MA:th"} xref: FMA:12234 xref: NCIT:C32528 xref: NLXANAT:090203 xref: SCTID:64482002 xref: UMLS:C0205889 {source="ncithesaurus:Epineurium"} xref: Wikipedia:Epineurium is_a: UBERON:0011822 {source="FMA"} ! dense irregular connective tissue relationship: BFO:0000050 UBERON:0000010 ! part of peripheral nervous system relationship: RO:0002221 UBERON:0001021 ! surrounds nerve property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/9/9c/Gray636.png" xsd:anyURI [Term] id: UBERON:0000125 name: neural nucleus def: "A spatially aggregated collection of nerve cell bodies in the CNS, consisting of one or more subpopulations that share cell type, chemical phenotype, and connections, and including nearby cells that share the same cell type, chemical phenotype, and connections. (CUMBO)." [NLX:28443] subset: cumbo synonym: "nervous system nucleus" EXACT [] synonym: "neuraxis nucleus" EXACT [FMA:83686] synonym: "neuronal nucleus" EXACT [AEO:0000136] synonym: "nucleus" BROAD [] synonym: "nucleus of CNS" EXACT [NLX:28443] synonym: "nucleus of neuraxis" RELATED [] xref: AEO:0000136 xref: FMA:83686 xref: NCIT:C13197 xref: NLX:28443 xref: Wikipedia:Nucleus_(neuroanatomy) is_a: UBERON:0011215 ! central nervous system cell part cluster relationship: RO:0002162 NCBITaxon:7711 ! in taxon Chordata relationship: RO:0002473 UBERON:0002020 ! composed primarily of gray matter property_value: skos:prefLabel "neural nucleus" xsd:string [Term] id: UBERON:0000126 name: cranial nerve nucleus def: "Nucleus that receives projections from or contains neurons that send projections through one of the cranial nerves." [NLX:28532] synonym: "cranial neural nucleus" EXACT [FMA:54501] synonym: "nucleus nervi cranialis" RELATED OMO:0003011 [Wikipedia:Cranial_nerve_nucleus] synonym: "nucleus of cranial nerve" EXACT [] xref: EMAPA:37066 {source="MA:th"} xref: FMA:54501 xref: NLX:28532 xref: SCTID:280160003 xref: Wikipedia:Cranial_nerve_nucleus is_a: UBERON:0002308 ! nucleus of brain intersection_of: UBERON:0002308 ! nucleus of brain intersection_of: extends_fibers_into UBERON:0001785 ! cranial nerve relationship: extends_fibers_into UBERON:0001785 ! cranial nerve property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/3/30/Gray696.png" xsd:anyURI property_value: skos:prefLabel "cranial nerve nucleus" xsd:string [Term] id: UBERON:0000127 name: facial nucleus def: "The group of motor neurons residing in the pons that innervate the muscles of facial expression." [ISBN:0838580343, MP:0000909] subset: pheno_slim synonym: "facial nerve nucleus" EXACT [] synonym: "facial VII motor nucleus" RELATED [MA:0001014] synonym: "facial VII nucleus" EXACT [MA:0001014] synonym: "nucleus of facial nerve" EXACT [FMA:54572] xref: BAMS:7 xref: BAMS:7N xref: BAMS:VII xref: BM:Pons-VII xref: DHBA:12420 xref: EHDAA2:0004638 xref: EMAPA:35338 xref: EV:0100267 xref: FMA:54572 xref: MA:0001014 xref: MESH:D065828 xref: NCIT:C12898 xref: SCTID:280166009 xref: UMLS:C0228740 {source="ncithesaurus:Facial_Nerve_Nucleus"} xref: VHOG:0001412 is_a: UBERON:0000126 ! cranial nerve nucleus is_a: UBERON:0004121 ! ectoderm-derived structure is_a: UBERON:0006331 ! brainstem nucleus is_a: UBERON:0009662 ! hindbrain nucleus intersection_of: UBERON:0000126 ! cranial nerve nucleus intersection_of: extends_fibers_into UBERON:0001647 ! facial nerve relationship: BFO:0000050 UBERON:0000988 ! part of pons relationship: extends_fibers_into UBERON:0001647 ! facial nerve relationship: RO:0002433 UBERON:0000988 ! contributes to morphology of pons relationship: RO:0002495 UBERON:0010123 {evidence="definitional"} ! immediate transformation of future facial nucleus property_value: skos:prefLabel "facial nucleus" xsd:string [Term] id: UBERON:0000153 name: anterior region of body is_a: UBERON:0000475 ! organism subdivision disjoint_from: UBERON:0000154 {source="lexical"} ! posterior region of body relationship: BSPO:0000096 UBERON:0000154 ! posterior region of body relationship: RO:0002162 NCBITaxon:33213 ! in taxon Bilateria property_value: skos:prefLabel "anterior region of body" xsd:string [Term] id: UBERON:0000154 name: posterior region of body is_a: UBERON:0000475 ! organism subdivision relationship: RO:0002162 NCBITaxon:33213 ! in taxon Bilateria property_value: skos:prefLabel "posterior region of body" xsd:string [Term] id: UBERON:0000155 name: theca cell layer def: "A layer of the ovarian follicle that consists of theca cells." [http://orcid.org/0000-0002-6601-2165] subset: efo_slim subset: human_reference_atlas subset: pheno_slim subset: vertebrate_core synonym: "layer of theca cells" EXACT [] synonym: "ovarian theca" RELATED [EMAPA:35636] synonym: "ovary theca" EXACT [MA:0001712] synonym: "theca cell layer of ovarian follicle" EXACT [] synonym: "theca folliculi" RELATED OMO:0003011 [Wikipedia:Theca_of_follicle] synonym: "theca of follicle" EXACT [] synonym: "thecal cell layer" EXACT [ZFA:0001113] synonym: "thecal cell layers" RELATED OMO:0003004 [ZFA:0001113] xref: BTO:0002853 xref: EFO:0003629 xref: EMAPA:35636 xref: FMA:18656 xref: MA:0001712 xref: SCTID:361385000 xref: TAO:0001113 xref: Wikipedia:Theca_of_follicle xref: ZFA:0001113 is_a: BFO:0000002 is_a: UBERON:0000119 ! cell layer is_a: UBERON:0005156 ! reproductive structure intersection_of: UBERON:0000119 ! cell layer intersection_of: BFO:0000050 UBERON:0001305 ! part of ovarian follicle intersection_of: RO:0002473 CL:0000503 ! composed primarily of theca cell relationship: BFO:0000050 UBERON:0001305 ! part of ovarian follicle relationship: RO:0002473 CL:0000503 ! composed primarily of theca cell property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0000156 name: theca externa def: "The theca externa is the outer layers of the theca folliculi. It contains abundant collagen and is mainly supportive." [Wikipedia:Theca_externa] subset: human_reference_atlas subset: pheno_slim synonym: "external coat of theca folliculi" RELATED [BTO:0002852] synonym: "ovary theca externa" EXACT [MA:0001713] synonym: "theca externa (folliculus ovaricus tertiarius)" EXACT [FMA:18657] synonym: "tunica externa of theca folliculi" EXACT [FMA:18657] synonym: "tunica externa thecae folliculi" RELATED OMO:0003011 [BTO:0002852, Wikipedia:Theca_externa] xref: BTO:0002852 xref: FMA:18657 xref: MA:0001713 xref: SCTID:258767003 xref: Wikipedia:Theca_externa is_a: UBERON:0000158 ! membranous layer is_a: UBERON:0005156 ! reproductive structure relationship: BFO:0000051 GO:0005581 ! has part collagen trimer relationship: RO:0002007 UBERON:0000155 ! bounding layer of theca cell layer relationship: RO:0002221 UBERON:0000157 ! surrounds theca interna property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/5/50/Mature_Graffian_follicle.jpg" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0000157 name: theca interna def: "Theca interna cells express receptors for luteinizing hormone, which when activated will stimulate the production of androstenedione from cholesterol by the enzyme desmolase. Androstenedione ultimately gives the granulosa cells the precursor substrate for estrogen manufacturing." [Wikipedia:Theca_externa#Theca_interna] subset: human_reference_atlas subset: pheno_slim synonym: "internal coat of capsule of Graafian follicle" RELATED [BTO:0002851] synonym: "ovary theca interna" EXACT [MA:0001714] synonym: "theca interna (folliculus ovaricus tertiarius)" EXACT [FMA:18658] synonym: "tunica interna of theca folliculi" EXACT [FMA:18658] synonym: "tunica interna thecae folliculi" RELATED [BTO:0002851] xref: BTO:0002851 xref: FMA:18658 xref: MA:0001714 xref: SCTID:258869006 xref: Wikipedia:Theca_externa#Theca_interna is_a: UBERON:0000158 ! membranous layer is_a: UBERON:0005156 ! reproductive structure relationship: BFO:0000050 UBERON:0000155 ! part of theca cell layer relationship: RO:0002433 UBERON:0000155 ! contributes to morphology of theca cell layer property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0000158 name: membranous layer synonym: "membrane" BROAD [] synonym: "membranous organ component" EXACT [FMA:82500] xref: FMA:30322 xref: FMA:82500 xref: MESH:D008566 xref: NCIT:C12749 is_a: UBERON:0004923 ! organ component layer relationship: RO:0002007 UBERON:0000064 ! bounding layer of organ part property_value: skos:prefLabel "membranous layer" xsd:string [Term] id: UBERON:0000159 name: anal canal def: "The terminal part of the large intestine, continuous proximally with the rectum and distally terminates with the anus." [Wikipedia:Anal_canal] subset: human_reference_atlas subset: pheno_slim subset: uberon_slim synonym: "anal canal" EXACT [] synonym: "anal canal viewed anatomically" EXACT [] synonym: "anal pad" RELATED [] synonym: "anatomical anal canal" EXACT [] synonym: "anus" RELATED [] synonym: "canalis analis" RELATED OMO:0003011 [BTO:0001978, Wikipedia:Anal_canal] synonym: "cloaca" RELATED [] synonym: "cloacal chamber" RELATED [] synonym: "mesenteron" RELATED [] synonym: "pars analis recti" RELATED [BTO:0001978] xref: BTO:0001978 xref: CALOHA:TS-2160 xref: EMAPA:18256 xref: FMA:15703 xref: galen:AnalCanal xref: MA:0000330 xref: NCIT:C12375 xref: SCTID:245438008 xref: UMLS:C0227411 {source="ncithesaurus:Anal_Canal"} xref: Wikipedia:Anal_canal is_a: BFO:0000002 is_a: UBERON:0004111 ! anatomical conduit relationship: BFO:0000050 UBERON:0000059 ! part of large intestine relationship: BFO:0000050 UBERON:0001353 ! part of anal region relationship: channel_for UBERON:0001988 ! feces relationship: RO:0002150 UBERON:0001052 ! continuous with rectum relationship: RO:0002150 UBERON:0001245 ! continuous with anus relationship: RO:0002202 UBERON:0011272 {source="Wikipathways:WP2062"} ! develops from embryonic skin basal layer property_value: foaf:depiction "https://upload.wikimedia.org/wikipedia/commons/0/01/Gray1078.png" xsd:anyURI property_value: IAO:0000116 "requires alignment with EHDAA2 and complete developmental relationships" xsd:string property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "anal canal" xsd:string [Term] id: UBERON:0000160 name: intestine def: "Segment of the alimentary canal extending from the stomach to the anus and, in humans and other mammals, consists of two segments, the small intestine and the large intestine." [GOC:GO, Wikipedia:Intestine] subset: efo_slim subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "bowel" EXACT [] synonym: "intestinal tract" RELATED [] xref: AAO:0000246 xref: ANISEED:1235303 xref: BSA:0000093 xref: BTO:0000648 xref: CALOHA:TS-0490 xref: EFO:0000834 xref: EMAPA:32874 xref: EV:0100071 xref: FMA:7199 xref: GAID:295 xref: galen:Intestine xref: MA:0000328 xref: MA:0001524 xref: MESH:D007422 xref: MIAA:0000043 xref: NCIT:C12736 xref: SCTID:256876008 xref: TAO:0001338 xref: UMLS:C0021853 {source="ncithesaurus:Intestine"} xref: VHOG:0000056 xref: WBbt:0005772 xref: Wikipedia:Intestine xref: XAO:0000129 xref: ZFA:0001338 is_a: UBERON:0004921 {source="cjm"} ! subdivision of digestive tract relationship: BFO:0000050 UBERON:0005409 ! part of alimentary part of gastrointestinal system relationship: RO:0002433 UBERON:0001007 ! contributes to morphology of digestive system property_value: IAO:0000116 "This class is probably too inclusive" xsd:string property_value: skos:prefLabel "intestine" xsd:string [Term] id: UBERON:0000161 name: orifice def: "Anatomical conduit that connects two adjacent body spaces (or a body space with the space surrounding the organism)[FMA,modified]." [FMA:3724] synonym: "anatomical orifice" EXACT [FMA:3724] synonym: "anatomical ostium" BROAD [FMA:3724] synonym: "hilum" NARROW [] synonym: "ostium" BROAD [] xref: FMA:3724 xref: SCTID:91837002 is_a: UBERON:0004111 ! anatomical conduit property_value: skos:prefLabel "orifice" xsd:string [Term] id: UBERON:0000162 name: cloaca def: "Common chamber into which the intestines and excretory system opens. Arises during development in all vertebrates, but in many it becomes subdivided, lost or incorporated into other structures." [ISBN:0073040584, Wikipedia:Cloaca] synonym: "cloacal chamber" RELATED [AAO:0000095] synonym: "vent" RELATED [XAO:0000244] xref: AAO:0000095 xref: GAID:1206 xref: MESH:D002988 xref: NCIT:C34127 xref: SCTID:362857006 xref: SCTID:370631000 xref: UMLS:C0008987 {source="ncithesaurus:Cloaca"} xref: VHOG:0001186 xref: Wikipedia:Cloaca xref: XAO:0000244 xref: ZFA:0005781 is_a: UBERON:0013522 ! subdivision of tube relationship: BFO:0000050 UBERON:0001555 {source="ZFA"} ! part of digestive tract relationship: BFO:0000050 UBERON:0004122 {source="AAO"} ! part of genitourinary system relationship: RO:0002162 NCBITaxon:7742 ! in taxon Vertebrata property_value: IAO:0000116 "adding df link to embryonic cloaca leads to a cycle in uberon-simple, as cloaca is a suberclass of embryonic cloaca" xsd:string property_value: skos:prefLabel "cloaca" xsd:string [Term] id: UBERON:0000163 name: embryonic cloaca def: "Endoderm-lined chamber that develops as pouch-like dilation of the caudal end of the hindgut and receives the allantois ventrally and two mesonephric ducts laterally; caudally it ends blindly at the cloacal membrane formed by the union of proctodeal (anal pit) ectoderm and cloacal endoderm, with no intervening mesoderm[MP]." [MP:0010115, Wikipedia:Cloaca_(embryology)] subset: pheno_slim synonym: "cloaca" RELATED SENSU [] xref: EHDAA2:0000256 xref: EHDAA:4895 xref: EMAPA:27573 xref: Wikipedia:Cloaca_(embryology) is_a: BFO:0000002 is_a: UBERON:0000162 ! cloaca relationship: BFO:0000050 UBERON:0000922 ! part of embryo relationship: BFO:0000050 UBERON:0001008 {source="EHDAA2"} ! part of renal system relationship: BFO:0000050 UBERON:0012361 {source="EHDAA2"} ! part of internal anal region relationship: RO:0002254 UBERON:0003064 ! has developmental contribution from intermediate mesoderm property_value: skos:prefLabel "embryonic cloaca" xsd:string [Term] id: UBERON:0000164 name: primitive urogenital sinus def: "The ventral part of the cloaca remaining after septation of the rectum, which further develops into part of the bladder, part of the prostatic part of the male urethra and the urethra and vestibule in females." [ISBN:0-683-40008-8, MP:0010116] subset: pheno_slim synonym: "fetal UGS" EXACT [PMID:18977204] synonym: "sinus urogenitalis" EXACT OMO:0003011 [] synonym: "UGS" EXACT [MP:0010116] synonym: "urogenital sinus" BROAD [MP:0010116] xref: EHDAA2:0004060 xref: EHDAA:5029 xref: EHDAA:5919 xref: EMAPA:17379 xref: NCIT:C34322 xref: SCTID:50961009 xref: UMLS:C0231057 {source="ncithesaurus:Urogenital_Sinus"} xref: VHOG:0000414 xref: Wikipedia:Definitive_urogenital_sinus is_a: BFO:0000002 is_a: UBERON:0002050 ! embryonic structure relationship: BFO:0000050 UBERON:0000163 {source="MP-def"} ! part of embryonic cloaca relationship: RO:0002202 UBERON:0003064 ! develops from intermediate mesoderm relationship: RO:0002433 UBERON:0000163 ! contributes to morphology of embryonic cloaca property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/6/6d/Gray1109.png" xsd:anyURI [Term] id: UBERON:0000165 name: mouth def: "The proximal portion of the digestive tract, containing the oral cavity and bounded by the oral opening. In vertebrates, this extends to the pharynx and includes gums, lips, tongue and parts of the palate. Typically also includes the teeth, except where these occur elsewhere (e.g. pharyngeal jaws) or protrude from the mouth (tusks)." [https://github.com/obophenotype/uberon/wiki/The-digestive-tract, Wikipedia:Mouth] subset: efo_slim subset: human_reference_atlas subset: major_organ subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "adult mouth" NARROW [] synonym: "cavital oralis" RELATED OMO:0003011 [Wikipedia:Mouth] synonym: "cavitas oris" RELATED [BTO:0001090] synonym: "cavum oris" RELATED [BTO:0001090] synonym: "mouth cavity" RELATED [BTO:0001090] synonym: "oral region" RELATED [EHDAA2:0001326] synonym: "oral vestibule" RELATED [BTO:0001090] synonym: "regio oralis" EXACT OMO:0003011 [BTO:0004698, FMA:49184, FMA:TA] synonym: "rima oris" RELATED [BTO:0001090] synonym: "stoma" RELATED [] synonym: "stomatodaeum" RELATED [VHOG:0000812] synonym: "trophic apparatus" RELATED [http://orcid.org/0000-0002-6601-2165] synonym: "vestibule of mouth" RELATED [BTO:0001090] synonym: "vestibulum oris" RELATED [BTO:0001090] xref: AAO:0010355 xref: BTO:0001090 xref: BTO:0004698 xref: CALOHA:TS-1315 xref: EFO:0000825 xref: EHDAA2:0001326 xref: EHDAA:542 xref: EMAPA:16262 xref: FBbt:00003126 {sssom:mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"} xref: FMA:49184 xref: GAID:75 xref: galen:Mouth xref: http://purl.obolibrary.org/obo/uberon/images/lamprey_sucker_rosava_3238889218.jpg xref: MA:0000341 xref: MA:0002474 xref: MAT:0000038 xref: MESH:D009055 xref: MIAA:0000038 xref: SCTID:21082005 xref: TADS:0000040 xref: TAO:0000547 xref: TAO:0000590 xref: TGMA:0000131 xref: VHOG:0000280 xref: VHOG:0000812 xref: Wikipedia:Mouth xref: XAO:0003029 xref: ZFA:0000547 xref: ZFA:0000590 is_a: BFO:0000002 is_a: UBERON:0004921 ! subdivision of digestive tract intersection_of: UBERON:0004921 ! subdivision of digestive tract intersection_of: BSPO:0001106 UBERON:0001555 ! digestive tract relationship: BSPO:0001106 UBERON:0001555 ! digestive tract relationship: RO:0002202 UBERON:0035804 ! develops from future mouth property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/0/06/Mouth_illustration-Otis_Archives.jpg" xsd:anyURI property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/mouth-female/v1.0/assets/3d-vh-f-mouth.glb" xsd:anyURI property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/mouth-male/v1.0/assets/3d-vh-m-mouth.glb" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 property_value: seeAlso "https://github.com/obophenotype/uberon/issues/661" xsd:anyURI property_value: skos:prefLabel "mouth" xsd:string [Term] id: UBERON:0000166 name: oral opening def: "The orifice that connects the mouth to the exterior of the body." [https://github.com/obophenotype/uberon/wiki/The-digestive-tract] subset: uberon_slim subset: vertebrate_core synonym: "mouth" RELATED INCONSISTENT [] synonym: "oral fissure" EXACT [FMA:59806] synonym: "oral orifice" EXACT [FMA:59806] synonym: "oral part of face" RELATED [] xref: FMA:59806 is_a: UBERON:0000161 {source="FMA"} ! orifice relationship: BFO:0000050 UBERON:0000165 ! part of mouth property_value: skos:prefLabel "oral opening" xsd:string [Term] id: UBERON:0000167 name: oral cavity def: "Anatomical cavity at the start of the digestive tract that that is enclosed by the mouth. The boundaries and contents vary depending on the species. In vertebrates, the boundaries are the oral opening, the cheeks, the palate and (if present) the palatoglossal arch - if this is not present then the mouth and pharynx form the oropharyngeal cavity. The buccal cavity contains the teeth, tongue and palate (when present)." [https://github.com/obophenotype/uberon/wiki/The-digestive-tract, https://orcid.org/0000-0002-6601-2165, ISBN:0073040584] subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "bucca" RELATED [] synonym: "buccal cavity" EXACT [FMA:20292, ISBN:0073040584] synonym: "cavity of mouth" EXACT [] xref: AAO:0000053 xref: AAO:0000960 xref: BSA:0000107 xref: CALOHA:TS-1315 xref: EFO:0001975 xref: EHDAA2:0001324 xref: EHDAA:6970 xref: EMAPA:17411 xref: EMAPA:18399 xref: EV:0100057 xref: FMA:20292 xref: HAO:0000669 xref: MESH:D009055 {sssom:mapping_justification="https://w3id.org/semapv/vocab/LexicalMatching"} xref: NCIT:C12421 xref: SCTID:181220002 xref: TAO:0001027 xref: TGMA:0000102 xref: UMLS:C0226896 {source="ncithesaurus:Oral_Cavity"} xref: VHOG:0000188 xref: WBbt:0005255 xref: XAO:0000126 xref: ZFA:0001027 is_a: UBERON:0002553 ! anatomical cavity intersection_of: UBERON:0000464 ! anatomical space intersection_of: RO:0002572 UBERON:0000165 ! luminal space of mouth relationship: RO:0002433 UBERON:0000165 ! contributes to morphology of mouth relationship: RO:0002572 UBERON:0000165 ! luminal space of mouth property_value: skos:prefLabel "oral cavity" xsd:string [Term] id: UBERON:0000168 name: proximal-distal subdivision of colon def: "A section dividing a colon along a proximal-distal axis." [http://orcid.org/0000-0002-6601-2165] subset: non_informative synonym: "segment of colon" RELATED [FMA:222905] xref: FMA:222905 is_a: UBERON:0004921 ! subdivision of digestive tract intersection_of: UBERON:0013522 ! subdivision of tube intersection_of: subdivision_of UBERON:0001155 ! colon relationship: BFO:0000050 UBERON:0001155 ! part of colon relationship: subdivision_of UBERON:0001155 ! colon property_value: skos:prefLabel "proximal-distal subdivision of colon" xsd:string [Term] id: UBERON:0000170 name: pair of lungs def: "The pair of anatomical structures comprised of a left lung and right lung." [http://orcid.org/0000-0002-6601-2165] subset: human_reference_atlas subset: pheno_slim synonym: "lungs" EXACT [] synonym: "lungs pair" EXACT [] synonym: "pulmones" EXACT OMO:0003011 [FMA:68877, FMA:TA] synonym: "set of lungs" EXACT [] xref: FMA:68877 is_a: BFO:0000002 is_a: BFO:0000004 is_a: UBERON:0034925 ! anatomical collection intersection_of: UBERON:0034925 ! anatomical collection intersection_of: RO:0002351 UBERON:0002167 ! has member right lung intersection_of: RO:0002351 UBERON:0002168 ! has member left lung relationship: BFO:0000050 UBERON:0001558 {source="FMA-abduced"} ! part of lower respiratory tract relationship: RO:0001025 UBERON:0002224 ! located in thoracic cavity relationship: RO:0002351 UBERON:0002167 ! has member right lung relationship: RO:0002351 UBERON:0002167 {cardinality="1"} ! has member right lung relationship: RO:0002351 UBERON:0002168 ! has member left lung relationship: RO:0002351 UBERON:0002168 {cardinality="1"} ! has member left lung property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "pair of lungs" xsd:string [Term] id: UBERON:0000171 name: respiration organ def: "Organ that functions in gaseous exchange between an organism and its environment. In plants, microorganisms, and many small animals, air or water makes direct contact with the organism's cells or tissue fluids, and the processes of diffusion supply the organism with dioxygen (O2) and remove carbon dioxide (CO2). In larger animals the efficiency of gaseous exchange is improved by specialized respiratory organs, such as lungs and gills, which are ventilated by breathing mechanisms." [GO:0007585] subset: functional_classification subset: organ_slim synonym: "apparatus respiratorius organ" EXACT [OBOL:automatic] synonym: "breathing organ" EXACT [] synonym: "gas exchange organ" RELATED [] synonym: "organ of apparatus respiratorius" EXACT [OBOL:automatic] synonym: "organ of respiratory system" EXACT [OBOL:automatic] synonym: "respiratory organ" EXACT [] synonym: "respiratory system organ" EXACT [OBOL:automatic] xref: SCTID:272626006 xref: SPD:0000428 xref: TGMA:0001247 is_a: UBERON:0000062 ! organ intersection_of: UBERON:0000062 ! organ intersection_of: RO:0002215 GO:0007585 ! capable of respiratory gaseous exchange by respiratory system relationship: BFO:0000050 UBERON:0001004 ! part of respiratory system relationship: RO:0002215 GO:0007585 ! capable of respiratory gaseous exchange by respiratory system property_value: skos:prefLabel "respiration organ" xsd:string [Term] id: UBERON:0000173 name: amniotic fluid def: "Amniotic fluid is a bodily fluid consisting of watery liquid surrounding and cushioning a growing fetus within the amnion. It allows the fetus to move freely without the walls of the uterus being too tight against its body. Buoyancy is also provided. The composition of the fluid changes over the course of gestation. Initially, amniotic fluid is similar to maternal plasma, mainly water with electrolytes. As the fetus develops, proteins, carbohydrates, lipids, phospholipids originating from the lungs, fetal cells, and urea are deposited in the fluid." [ENVO:02000021, MP:MP] subset: pheno_slim synonym: "acqua amnii" RELATED OMO:0003011 [BTO:0000068] synonym: "liquor amnii" RELATED OMO:0003011 [BTO:0000068] xref: BTO:0000068 xref: CALOHA:TS-0034 xref: EMAPA:36771 xref: ENVO:02000021 xref: EV:0100123 xref: FMA:305905 xref: GAID:1155 xref: MA:0002893 xref: MESH:D000653 xref: NCIT:C13188 xref: UMLS:C0002638 {source="ncithesaurus:Amniotic_Fluid"} xref: VHOG:0001267 is_a: UBERON:0000463 ! organism substance relationship: RO:0001025 UBERON:0000305 ! located in amnion relationship: RO:0002162 NCBITaxon:32524 ! in taxon Amniota relationship: RO:0002221 UBERON:0000922 ! surrounds embryo relationship: RO:0002328 GO:0001701 ! functionally related to in utero embryonic development [Term] id: UBERON:0000174 name: excreta def: "A portion of organism substance that is the product of an excretion process that will be eliminated from the body. An excretion process is elimination by an organism of the waste products that arise as a result of metabolic activity." [GO:0007588, http://orcid.org/0000-0002-6601-2165] synonym: "excreted substance" EXACT [] synonym: "excretion" RELATED [BTO:0000491] synonym: "portion of excreted substance" EXACT [FMA:9674] synonym: "waste substance" EXACT [AEO:0000184] xref: AEO:0000184 xref: BTO:0000491 xref: EHDAA2_RETIRED:0003184 xref: ENVO:02000022 xref: FMA:9674 xref: galen:Excretion is_a: BFO:0000002 is_a: UBERON:0000463 ! organism substance intersection_of: UBERON:0000463 ! organism substance intersection_of: RO:0002353 GO:0007588 ! output of excretion relationship: RO:0002353 GO:0007588 ! output of excretion property_value: skos:prefLabel "excreta" xsd:string [Term] id: UBERON:0000178 name: blood def: "A fluid that is composed of blood plasma and erythrocytes." [FMA:9670, http://orcid.org/0000-0002-6601-2165, https://github.com/obophenotype/uberon/issues/9, Wikipedia:Blood] subset: efo_slim subset: human_reference_atlas subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "portion of blood" EXACT [] synonym: "vertebrate blood" EXACT [] synonym: "whole blood" RELATED [BTO:0000089] xref: AAO:0000046 xref: BTO:0000089 xref: CALOHA:TS-0079 xref: EFO:0000296 xref: EHDAA2:0000176 xref: EHDAA:418 xref: EMAPA:16332 xref: ENVO:02000027 xref: EV:0100047 xref: FMA:9670 xref: GAID:965 xref: galen:Blood xref: MA:0000059 xref: MESH:D001769 xref: MIAA:0000315 xref: NCIT:C12434 xref: TAO:0000007 xref: UMLS:C0005767 {source="ncithesaurus:Blood"} xref: VHOG:0000224 xref: Wikipedia:Blood xref: XAO:0000124 xref: ZFA:0000007 is_a: BFO:0000002 is_a: UBERON:0000061 ! anatomical structure is_a: UBERON:0000179 ! haemolymphatic fluid relationship: BFO:0000050 UBERON:0002390 ! part of hematopoietic system relationship: BFO:0000051 CL:0000232 {source="CL:tm"} ! has part erythrocyte relationship: BFO:0000051 UBERON:0001969 ! has part blood plasma relationship: RO:0001025 UBERON:0002049 {source="https://github.com/obophenotype/uberon/issues/1330"} ! located in vasculature relationship: RO:0002495 UBERON:0006596 {source="Bgee:AN"} ! immediate transformation of presumptive blood property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "blood" xsd:string property_value: terms:contributor https://orcid.org/0000-0002-6601-2165 property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 [Term] id: UBERON:0000179 name: haemolymphatic fluid def: "Circulating fluid that is part of the hemolymphoid system. Blood, lymph, interstitial fluid or its analogs." [http://orcid.org/0000-0002-6601-2165] synonym: "blood or blood analog" RELATED [] synonym: "circulating fluid" RELATED [] xref: CARO:0000081 is_a: UBERON:0006314 ! bodily fluid intersection_of: UBERON:0000463 ! organism substance intersection_of: BFO:0000050 UBERON:0002193 ! part of hemolymphoid system relationship: BFO:0000050 UBERON:0002193 ! part of hemolymphoid system property_value: skos:prefLabel "haemolymphatic fluid" xsd:string property_value: terms:contributor https://orcid.org/0000-0002-6601-2165 creation_date: 2009-04-08T04:38:19Z [Term] id: UBERON:0000200 name: gyrus def: "A ridge on the cerebral cortex. It is generally surrounded by one or more sulci ." [https://github.com/obophenotype/uberon/issues/573, Wikipedia:Gyrus] subset: pheno_slim synonym: "cerebral gyrus" EXACT [BTO:0002495] synonym: "folia" RELATED OMO:0003004 [] synonym: "folium" RELATED [PHENOSCAPE:wd] synonym: "folium of brain" RELATED [] synonym: "gyri" RELATED OMO:0003004 [BTO:0002495] synonym: "gyri of cerebrum" RELATED OMO:0003004 [BTO:0002495] synonym: "gyrus of cerebral hemisphere" RELATED [FMA:83874] synonym: "gyrus of cerebrum" RELATED [BTO:0002495] synonym: "gyrus of neuraxis" EXACT [FMA:83874] synonym: "neuraxis gyrus" EXACT [FMA:83874] xref: BTO:0002495 xref: FMA:83874 xref: NCIT:C32290 xref: neuronames:1211 xref: SCTID:279165009 xref: UMLS:C0458308 {source="ncithesaurus:Cerebral_Gyrus"} xref: Wikipedia:Gyrus is_a: UBERON:0034768 ! morphological feature relationship: BFO:0000050 UBERON:0000956 ! part of cerebral cortex relationship: RO:0002162 NCBITaxon:40674 ! in taxon Mammalia relationship: RO:0002219 UBERON:0013118 ! surrounded by sulcus of brain property_value: seeAlso "https://github.com/obophenotype/uberon/issues/573" xsd:anyURI property_value: skos:prefLabel "gyrus" xsd:string property_value: terms:contributor https://orcid.org/0000-0002-1572-1316 property_value: terms:contributor https://orcid.org/0000-0002-6601-2165 property_value: terms:contributor https://orcid.org/0000-0003-3162-7490 [Term] id: UBERON:0000201 name: endothelial blood brain barrier def: "A blood brain barrier that is composed of endothelial cells." [https://orcid.org/0000-0002-6601-2165] xref: NIF_Subcellular:nlx_subcell_100205 is_a: BFO:0000002 is_a: UBERON:0000120 ! blood brain barrier intersection_of: UBERON:0000120 ! blood brain barrier intersection_of: RO:0002473 CL:0000115 ! composed primarily of endothelial cell relationship: RO:0002473 CL:0000115 ! composed primarily of endothelial cell property_value: skos:prefLabel "endothelial blood brain barrier" xsd:string property_value: terms:contributor https://orcid.org/0000-0002-6601-2165 creation_date: 2009-04-10T08:15:44Z [Term] id: UBERON:0000202 name: glial blood brain barrier def: "A blood brain barrier composed of glial cells." [https://orcid.org/0000-0002-6601-2165] xref: FBbt:00007091 {sssom:mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"} is_a: BFO:0000002 is_a: UBERON:0000120 ! blood brain barrier intersection_of: UBERON:0000120 ! blood brain barrier intersection_of: RO:0002473 CL:0000125 ! composed primarily of glial cell relationship: RO:0002473 CL:0000125 ! composed primarily of glial cell property_value: skos:prefLabel "glial blood brain barrier" xsd:string property_value: terms:contributor https://orcid.org/0000-0002-6601-2165 creation_date: 2009-04-10T08:42:24Z [Term] id: UBERON:0000203 name: pallium def: "Dorsal part (roof region) of the telencephalon[GO]." [GO:0021543, https://github.com/obophenotype/uberon/issues/287, ISBN:0471888893, Wikipedia:Pallium_(neuroanatomy)] subset: developmental_classification subset: efo_slim synonym: "area dorsalis telencephali" EXACT [ZFA:0000505] synonym: "dorsal part of telencephalon" EXACT [ISBN:0471888893] synonym: "dorsal telencephalic area" EXACT [ZFA:0000505] synonym: "dorsal telencephalon" EXACT [ZFA:0000505] xref: BTO:0003399 xref: DMBA:15903 xref: EFO:0003534 xref: neuronames:3240 xref: SCTID:369224000 xref: TAO:0000505 xref: TAO:0007007 xref: Wikipedia:Avian_pallium xref: Wikipedia:Pallium_(neuroanatomy) xref: ZFA:0000505 is_a: UBERON:0002616 ! regional part of brain relationship: BFO:0000050 UBERON:0001893 ! part of telencephalon property_value: RO:0002175 NCBITaxon:7762 {source="PMID:8932866"} property_value: seeAlso "https://sourceforge.net/p/obo/zebrafish-anatomy-zfa-term-requests/87" xsd:anyURI property_value: skos:prefLabel "pallium" xsd:string property_value: terms:contributor https://orcid.org/0000-0002-6601-2165 creation_date: 2009-04-18T12:03:09Z [Term] id: UBERON:0000204 name: ventral part of telencephalon def: "Ventral part (base region) of the telencephalon." [GO:0021544, GO_REF:0000021, ISBN:0471888893, PMID:12626695] subset: developmental_classification subset: efo_slim synonym: "area ventralis telencephali" EXACT [ZFA:0000304] synonym: "subpallium" EXACT [GO:0021544, ZFA:0000304] synonym: "subpallium" NARROW [BTO:0003401, NCBITaxon:8782] synonym: "ventral telencephalon" EXACT [ZFA:0000304] xref: BTO:0003401 xref: DMBA:15751 xref: EFO:0003522 xref: TAO:0000304 xref: ZFA:0000304 is_a: UBERON:0002616 ! regional part of brain relationship: BFO:0000050 UBERON:0001893 ! part of telencephalon relationship: BSPO:0000098 UBERON:0000203 ! pallium property_value: skos:prefLabel "ventral part of telencephalon" xsd:string property_value: terms:contributor https://orcid.org/0000-0002-6601-2165 creation_date: 2009-04-18T12:12:27Z [Term] id: UBERON:0000209 name: tetrapod frontal bone def: "The bone forming the forehead and roof of the eye orbit." [ISBN:0-683-40008-8, MP:0000107, PMID:7914451, Wikipedia:Frontal_bone] subset: human_reference_atlas subset: pheno_slim synonym: "frontal" NARROW [AAO:0000206] synonym: "frontal bone" NARROW SENSU [FMA:52734, MA:0001466] synonym: "os frontal" NARROW SENSU [Wikipedia:Frontal_bone] synonym: "os frontale" RELATED OMO:0003011 [Wikipedia:Frontal_bone] xref: AAO:0000206 xref: EMAPA:19016 xref: FMA:52734 xref: GAID:226 xref: MA:0001466 xref: MESH:D005624 xref: NCIT:C32635 xref: SCTID:181793006 xref: UMLS:C0016732 {source="ncithesaurus:Frontal_Bone"} xref: VSAO:0000208 xref: Wikipedia:Frontal_bone is_a: UBERON:0002514 ! intramembranous bone is_a: UBERON:0008907 ! dermal bone is_a: UBERON:0010428 {source="FMA"} ! flat bone is_a: UBERON:0011164 ! neurocranium bone relationship: BFO:0000050 UBERON:0003113 {source="cjm"} ! part of dermatocranium relationship: RO:0002131 UBERON:0001697 ! overlaps orbit of skull property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/9/97/Gray136.png" xsd:anyURI property_value: foaf:depiction "https://upload.wikimedia.org/wikipedia/commons/5/5b/Frontal_bone.png" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "tetrapod frontal bone" xsd:string [Term] id: UBERON:0000211 name: ligament def: "Dense regular connective tissue connecting two or more adjacent skeletal elements or supporting an organ." [GO_REF:0000034, http://dx.plos.org/10.1371/journal.pone.0051070, VSAO:0000073] subset: efo_slim subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "ligament organ" EXACT [FMA:21496] xref: CALOHA:TS-2145 xref: EFO:0001966 xref: EMAPA:35493 xref: FMA:21496 xref: FMA:30319 xref: galen:Ligament xref: MA:0000113 xref: MESH:D008022 xref: NCIT:C13046 xref: SCTID:182358004 xref: TAO:0001682 xref: UMLS:C0023685 {source="ncithesaurus:Ligament"} xref: VHOG:0001272 xref: Wikipedia:Ligament xref: XAO:0004031 xref: ZFA:0001675 is_a: UBERON:0000062 ! organ relationship: BFO:0000051 UBERON:0002384 ! has part connective tissue relationship: RO:0002162 NCBITaxon:33213 ! in taxon Bilateria property_value: foaf:depiction "https://upload.wikimedia.org/wikipedia/commons/9/9a/Knee_diagram.svg" xsd:anyURI [Term] id: UBERON:0000218 name: vertebral arch of axis def: "A neural arch that is part of a vertebral bone 2." [OBOL:automatic] synonym: "vertebral foramen of cervical vertebra 2" EXACT [] xref: FMA:24053 is_a: UBERON:0003861 ! neural arch intersection_of: UBERON:0003861 ! neural arch intersection_of: BFO:0000050 UBERON:0001093 ! part of vertebral bone 2 relationship: BFO:0000050 UBERON:0001093 ! part of vertebral bone 2 [Term] id: UBERON:0000219 name: vertebral foramen of atlas synonym: "vertebral foramen of cervical vertebra 1" EXACT [] xref: FMA:24293 xref: SCTID:281228008 xref: Wikipedia:Atlas_(anatomy)#Vertebral_foramen is_a: UBERON:0001131 ! vertebral foramen is_a: UBERON:0005744 ! bone foramen intersection_of: UBERON:0001131 ! vertebral foramen intersection_of: BFO:0000050 UBERON:0001092 ! part of vertebral bone 1 relationship: BFO:0000050 UBERON:0001092 ! part of vertebral bone 1 [Term] id: UBERON:0000220 name: atlanto-occipital joint def: "The Atlanto-occipital joint (articulation between the atlas and the occipital bone) consists of a pair of condyloid joints. The atlanto-occipital joint is a synovial joint. The ligaments connecting the bones are: Two Articular capsules; Posterior atlantoöccipital membrane; Anterior atlantoöccipital membrane; Lateral atlantoöccipital." [Wikipedia:Atlanto-occipital_joint] synonym: "articulatio atlanto-occipitalis" EXACT [FMA:24939] synonym: "articulatio atlantooccipitalis" RELATED OMO:0003011 [Wikipedia:Atlanto-occipital_joint] synonym: "atlanto occipital joint" EXACT [] synonym: "atlantooccipital joint" EXACT [] synonym: "craniovertebral joint" EXACT [FMA:24939] synonym: "occipito atlantal joint" EXACT [] synonym: "occipito-atlantal joint" EXACT [] xref: FMA:24939 xref: NCIT:C32158 xref: ncithesaurus:Atlanto-occipital_Joint-Atlanto xref: SCTID:361831006 xref: UMLS:C0004169 {source="ncithesaurus:Atlanto-occipital_Joint"} xref: Wikipedia:Atlanto-occipital_joint is_a: UBERON:0002217 ! synovial joint is_a: UBERON:0015212 ! lateral structure intersection_of: UBERON:0002217 ! synovial joint intersection_of: RO:0002176 UBERON:0001092 ! connects vertebral bone 1 intersection_of: RO:0002176 UBERON:0001676 ! connects occipital bone relationship: BSPO:0000126 UBERON:0006072 {source="FMA-abduced-lr"} ! cervical region of vertebral column relationship: RO:0002176 UBERON:0001092 ! connects vertebral bone 1 relationship: RO:0002176 UBERON:0001676 ! connects occipital bone property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/d/d4/Gray304.png" xsd:anyURI property_value: skos:prefLabel "atlanto-occipital joint" xsd:string [Term] id: UBERON:0000304 name: tendon sheath def: "A layer of membrane around a tendon. It has 2 layers: synovial sheath + fibrous tendon sheath." [Wikipedia:Tendon_sheath] synonym: "synovial tendon sheath" EXACT [FMA:45087] synonym: "vagina tendinis" RELATED OMO:0003011 [Wikipedia:Tendon_sheath] xref: BTO:0000051 xref: FMA:45087 xref: FMA:76715 xref: NCIT:C96299 xref: SCTID:361885006 xref: UMLS:C0224856 {source="ncithesaurus:Tendon_Sheath"} xref: Wikipedia:Tendon_sheath is_a: BFO:0000002 is_a: UBERON:0004923 ! organ component layer intersection_of: UBERON:0004923 ! organ component layer intersection_of: RO:0002007 UBERON:0000043 ! bounding layer of tendon relationship: BFO:0000051 UBERON:0011233 ! has part synovial membrane of synovial tendon sheath relationship: BFO:0000051 UBERON:0011234 ! has part fibrous membrane of synovial tendon sheath relationship: RO:0002007 UBERON:0000043 ! bounding layer of tendon property_value: IAO:0000116 "TODO - add layer relations. 'tendon sheath' GAT in FMA." xsd:string property_value: skos:prefLabel "tendon sheath" xsd:string [Term] id: UBERON:0000305 name: amnion def: "The thin innermost layer of the extraembryonic membranes that contains the amniotic fluid; the membrane forms a closed sac in which the embryo and later, the fetus, is suspended and protected." [MGI:csmith, MP:0005029] subset: human_reference_atlas subset: pheno_slim synonym: "amnios" EXACT [http://placentation.ucsd.edu/glossfs.html] xref: BTO:0000065 xref: CALOHA:TS-0033 xref: EHDAA2:0000116 xref: EHDAA:136 xref: EMAPA:16109 xref: EV:0100122 xref: FMA:80223 xref: GAID:1298 xref: MESH:D000650 xref: NCIT:C12365 xref: SCTID:181457005 xref: UMLS:C0002630 {source="ncithesaurus:Amnion"} xref: VHOG:0000721 xref: Wikipedia:Amnion is_a: BFO:0000002 is_a: UBERON:0005631 ! extraembryonic membrane relationship: BFO:0000051 UBERON:0003254 ! has part amniotic ectoderm relationship: BFO:0000051 UBERON:0003262 ! has part amniotic mesoderm relationship: RO:0002202 UBERON:0005971 {source="ISBN:0073040584"} ! develops from amniotic fold relationship: RO:0002221 UBERON:0000922 ! surrounds embryo relationship: RO:0002254 UBERON:0000924 {source="ISBN:0073040584-table5.4"} ! has developmental contribution from ectoderm relationship: RO:0002254 UBERON:0004871 {source="ISBN:0073040584-table5.4"} ! has developmental contribution from somatic layer of lateral plate mesoderm property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/e/e7/Gray14.png" xsd:anyURI property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/placenta-full-term-female/v1.1/assets/3d-vh-f-placenta-full-term.glb" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0000307 name: blastula def: "Organism at the blastula stage - an early stage of embryonic development in animals. It is produced by cleavage of a fertilized ovum and consists of a spherical layer of around 128 cells surrounding a central fluid-filled cavity called the blastocoel. The blastula follows the morula and precedes the gastrula in the developmental sequence." [Wikipedia:Blastula] subset: inconsistent_with_fma synonym: "blastosphere" RELATED [Wikipedia:Blastula] synonym: "blastula embryo" EXACT [BILA:0000059] xref: BILA:0000059 xref: BTO:0000128 xref: GAID:1294 xref: MESH:D036703 xref: OGEM:000006 xref: Wikipedia:Blastula is_a: BFO:0000002 is_a: UBERON:0000922 ! embryo intersection_of: UBERON:0000468 ! multicellular organism intersection_of: RO:0002491 UBERON:0000108 ! existence starts and ends during blastula stage relationship: RO:0002202 UBERON:0007010 ! develops from cleaving embryo relationship: RO:0002491 UBERON:0000108 ! existence starts and ends during blastula stage property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/c/c6/Blastulation.png" xsd:anyURI property_value: IAO:0000116 "TODO - check relationship with epiblast. Note in FMA this is not a subclass of embryo, but in uberon embryo is the whole organism from zygote onwards and thus includes the blastula" xsd:string property_value: skos:prefLabel "blastula" xsd:string [Term] id: UBERON:0000309 name: body wall def: "The external portion of an animal body derived from ectoderm and mesoderm layers that encloses the body cavity." [MP:0003385] subset: pheno_slim synonym: "trunk wall" NARROW [FMA:10427] synonym: "wall fo trunk" EXACT [FMA:10427] synonym: "wall of trunk" NARROW [FMA:10427] xref: BTO:0000139 xref: EMAPA:32761 xref: FMA:10427 xref: galen:BodyWall xref: SCTID:281483004 is_a: UBERON:0000475 ! organism subdivision [Term] id: UBERON:0000310 name: breast def: "The upper ventral region of the torso of an organism." [Wikipedia:Breast] subset: pheno_slim synonym: "mamma" RELATED OMO:0003011 [Wikipedia:Breast] synonym: "mammary part of chest" EXACT [FMA:9601] synonym: "mammary region" EXACT [FMA:9601] xref: BTO:0000149 xref: CALOHA:TS-2083 xref: EV:0100124 xref: FMA:9601 xref: GAID:33 xref: galen:Breast xref: MESH:D001940 xref: NCIT:C12971 xref: SCTID:181131000 xref: UMLS:C0006141 {source="ncithesaurus:Breast"} xref: Wikipedia:Breast is_a: UBERON:0034929 ! external soft tissue zone relationship: BFO:0000050 UBERON:0001443 ! part of chest property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/6/6e/Closeup_of_female_breast.jpg" xsd:anyURI [Term] id: UBERON:0000313 name: portion of cartilage tissue in tibia def: "Cartilage pertaining to the tibia." [Dorlands_Medical_Dictionary:MerckSource] synonym: "cartilage of tibia" RELATED [FMA:33923] synonym: "tibial cartilage" EXACT [] xref: BTO:0000207 xref: FMA:33923 is_a: UBERON:0004270 ! lower leg connective tissue is_a: UBERON:0007391 ! pelvic appendage cartilage tissue intersection_of: UBERON:0002418 ! cartilage tissue intersection_of: BFO:0000050 UBERON:0000979 ! part of tibia relationship: BFO:0000050 UBERON:0000979 ! part of tibia [Term] id: UBERON:0000314 name: cecum mucosa def: "A mucosa that is part of a cecum [Automatically generated definition]." [OBOL:automatic] subset: human_reference_atlas synonym: "caecum mucosa" EXACT [OBOL:automatic] synonym: "caecum mucosa of organ" EXACT [OBOL:automatic] synonym: "caecum mucous membrane" EXACT [OBOL:automatic] synonym: "caecum organ mucosa" EXACT [OBOL:automatic] synonym: "cecal mucosa" EXACT [FMA:14998] synonym: "cecum mucosa of organ" EXACT [OBOL:automatic] synonym: "cecum mucous membrane" EXACT [OBOL:automatic] synonym: "cecum organ mucosa" EXACT [OBOL:automatic] synonym: "intestinum crassum caecum mucosa" EXACT [OBOL:automatic] synonym: "intestinum crassum caecum mucosa of organ" EXACT [OBOL:automatic] synonym: "intestinum crassum caecum mucous membrane" EXACT [OBOL:automatic] synonym: "intestinum crassum caecum organ mucosa" EXACT [OBOL:automatic] synonym: "mucosa of caecum" EXACT [OBOL:automatic] synonym: "mucosa of cecum" EXACT [OBOL:automatic] synonym: "mucosa of intestinum crassum caecum" EXACT [OBOL:automatic] synonym: "mucosa of organ of caecum" EXACT [OBOL:automatic] synonym: "mucosa of organ of cecum" EXACT [OBOL:automatic] synonym: "mucosa of organ of intestinum crassum caecum" EXACT [OBOL:automatic] synonym: "mucous membrane of caecum" EXACT [OBOL:automatic] synonym: "mucous membrane of cecum" EXACT [OBOL:automatic] synonym: "mucous membrane of intestinum crassum caecum" EXACT [OBOL:automatic] synonym: "organ mucosa of caecum" EXACT [OBOL:automatic] synonym: "organ mucosa of cecum" EXACT [OBOL:automatic] synonym: "organ mucosa of intestinum crassum caecum" EXACT [OBOL:automatic] xref: BTO:0000213 xref: FMA:14998 is_a: UBERON:0000317 ! colonic mucosa intersection_of: UBERON:0000344 ! mucosa intersection_of: BFO:0000050 UBERON:0001153 ! part of caecum relationship: BFO:0000050 UBERON:0001153 ! part of caecum property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0000315 name: subarachnoid space def: "The space between the arachnoid and pia mater." [GOC:add, https://sourceforge.net/p/obo/mammalian-phenotype-requests/1168/, Wikipedia:Subarachnoid_space] subset: pheno_slim synonym: "cavitas subarachnoidea" RELATED OMO:0003011 [BTO:0000230] synonym: "cavum subarachnoideale" RELATED OMO:0003011 [Wikipedia:Subarachnoid_space] synonym: "spatium leptomeningeum" RELATED OMO:0003011 [BTO:0000230] synonym: "spatium subarachnoideum" RELATED OMO:0003011 [BTO:0000230, Wikipedia:Subarachnoid_space] synonym: "subarachnoid cavity" RELATED [BTO:0000230] synonym: "subarachnoid space of central nervous system" EXACT [] synonym: "subarachnoid space of CNS" EXACT [] synonym: "subarachnoid space of neuraxis" EXACT [FMA:322060] xref: BTO:0000230 xref: EMAPA:32666 xref: FMA:83716 xref: GAID:689 xref: MESH:D013346 xref: SCTID:362311001 xref: Wikipedia:Subarachnoid_space is_a: UBERON:0000464 ! anatomical space intersection_of: UBERON:0000464 ! anatomical space intersection_of: RO:0002220 UBERON:0002361 ! adjacent to pia mater intersection_of: RO:0002220 UBERON:0002362 ! adjacent to arachnoid mater relationship: BFO:0000050 UBERON:0010743 ! part of meningeal cluster relationship: RO:0001015 UBERON:0001359 ! location of cerebrospinal fluid relationship: RO:0001015 UBERON:0001981 {source="ISBN:0471888893"} ! location of blood vessel relationship: RO:0002220 UBERON:0002361 ! adjacent to pia mater relationship: RO:0002220 UBERON:0002362 ! adjacent to arachnoid mater property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/5/5f/Gray769-en.svg" xsd:anyURI property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/f/f8/Gray769.png" xsd:anyURI property_value: skos:prefLabel "subarachnoid space" xsd:string [Term] id: UBERON:0000316 name: cervical mucus def: "A substance produced by the cervix and endocervical glands[BTO]. Thick acidic mucus that blocks the cervical os after mestruation[WP]. This 'infertile' mucus blocks spermatozoa from entering the uterus." [BTO:0000242, Wikipedia:Cervix#Cervical_mucus, Wikipedia:Mucus#Reproductive_system] synonym: "cervix mucus" EXACT [OBOL:automatic] xref: BTO:0000242 xref: FMA:83689 xref: MESH:D002582 xref: Wikipedia:Mucus#Reproductive_system is_a: UBERON:0000912 ! mucus intersection_of: UBERON:0000912 ! mucus intersection_of: RO:0003001 UBERON:0000002 ! produced by uterine cervix relationship: RO:0003001 UBERON:0000002 ! produced by uterine cervix [Term] id: UBERON:0000317 name: colonic mucosa def: "Mucosa that is part of a colon. The mucosa of the colon is lined by a simple columnar epithelium with a thin brush border and numerous goblet cells." [http://orcid.org/0000-0002-6601-2165] subset: efo_slim subset: human_reference_atlas synonym: "colon mucosa" EXACT [FMA:14984] synonym: "colon mucous membrane" EXACT [OBOL:automatic] synonym: "colonic mucosa" EXACT [] synonym: "colonic mucous membrane" EXACT [FMA:14984] synonym: "large bowel mucosa" EXACT [OBOL:automatic] synonym: "mucosa of colon" EXACT [FMA:14984] synonym: "mucosa of large bowel" EXACT [OBOL:automatic] xref: BTO:0000271 xref: CALOHA:TS-0164 xref: EFO:0003038 xref: EMAPA:27375 xref: FMA:14984 xref: FMA:85388 xref: MA:0003194 xref: SCTID:362157008 is_a: UBERON:0001207 ! mucosa of large intestine intersection_of: UBERON:0000344 ! mucosa intersection_of: BFO:0000050 UBERON:0001155 ! part of colon relationship: BFO:0000050 UBERON:0001155 ! part of colon property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "colonic mucosa" xsd:string [Term] id: UBERON:0000320 name: duodenal mucosa def: "A mucosa that is part of a duodenum [Automatically generated definition]." [OBOL:automatic] subset: human_reference_atlas synonym: "doudenal mucosa" EXACT [FMA:14942] synonym: "duodenal mucous membrane" EXACT [FMA:14942] synonym: "duodenum mucosa" RELATED [BTO:0000367] synonym: "mucosa of duodenum" EXACT [OBOL:automatic] synonym: "mucous membrane of duodenum" EXACT [OBOL:automatic] xref: BTO:0000367 xref: CALOHA:TS-0213 xref: EMAPA:27235 xref: FMA:14942 xref: MA:0003207 xref: SCTID:362146003 is_a: UBERON:0001204 ! mucosa of small intestine intersection_of: UBERON:0000344 ! mucosa intersection_of: BFO:0000050 UBERON:0002114 ! part of duodenum relationship: BFO:0000050 UBERON:0002114 ! part of duodenum property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "duodenal mucosa" xsd:string [Term] id: UBERON:0000323 name: late embryo def: "An embryo that is at the late embryonic stage; this stage covers late steps of the embryogenesis with a fully formed embryo still developing before birth or egg hatching." [https://orcid.org/0000-0003-3308-6245] subset: efo_slim subset: pheno_slim synonym: "embryo late growth stage" RELATED [BTO:0000449] synonym: "embryo late stage" RELATED [BTO:0000449] synonym: "fetus" NARROW [BTO:0000449] xref: BTO:0000449 xref: CALOHA:TS-0360 xref: EFO:0001323 xref: FBbt:00005333 {sssom:mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"} xref: FMA:63919 xref: GAID:552 xref: MESH:D005333 xref: NCIT:C13235 xref: SCTID:83418008 xref: UMLS:C0015965 {source="ncithesaurus:Fetus"} is_a: UBERON:0000922 ! embryo intersection_of: UBERON:0000922 ! embryo intersection_of: RO:0002491 UBERON:0007220 ! existence starts and ends during late embryonic stage relationship: RO:0002491 UBERON:0007220 ! existence starts and ends during late embryonic stage property_value: IAO:0000116 "TODO - check fetus/embryo. WP: An embryo is a multicellular diploid eukaryote in its earliest stage of development, from the time of first cell division until birth, hatching, or germination. In humans, it is called an embryo until about eight weeks after fertilization (i.e. ten weeks LMP), and from then it is instead called a fetus." xsd:string [Term] id: UBERON:0000325 name: gastric gland def: "The branched tubular glands found in the mucosa of the fundus and body of the stomach which contain parietal cells that secrete hydrochloric acid and zymogenic cells that produce pepsin." [MGI:anna] subset: organ_slim subset: pheno_slim xref: BTO:0000503 xref: EMAPA:27181 xref: FMA:14919 is_a: UBERON:0002365 {source="cjm"} ! exocrine gland is_a: UBERON:0003294 ! gland of foregut relationship: BFO:0000050 UBERON:0006924 {source="ISBN:0073040584"} ! part of stomach glandular epithelium property_value: skos:prefLabel "gastric gland" xsd:string [Term] id: UBERON:0000326 name: pancreatic juice def: "Pancreatic juice is slightly alkaline and contains numerous enzymes and inactive enzyme precursors including alpha-amylase, chymotrypsinogen, lipase, procarboxypeptidase, proelastase, prophospholipase A2, ribonuclease, and trypsinogen. Its high concentration of bicarbonate ions helps to neutralize the acid from the stomach." [GO:0030157] synonym: "pancreatic fluid" RELATED [] synonym: "pancreatic secretion" RELATED [] synonym: "succus pancreaticus" RELATED [BTO:0000504] xref: BTO:0000504 xref: CALOHA:TS-2235 xref: FMA:62973 xref: GAID:1166 xref: MESH:D010189 is_a: UBERON:0000456 ! secretion of exocrine gland intersection_of: UBERON:0000456 ! secretion of exocrine gland intersection_of: RO:0003001 UBERON:0001264 ! produced by pancreas relationship: RO:0003001 UBERON:0001264 ! produced by pancreas property_value: skos:prefLabel "pancreatic juice" xsd:string [Term] id: UBERON:0000328 name: gut wall def: "The wall of the digestive tract. This encompasses all parts of the digestive tract with the exception of the lumen (cavity)." [http://orcid.org/0000-0002-6601-2165] synonym: "digestive tract wall" EXACT [] synonym: "wall of alimentary tract" RELATED [] synonym: "wall of digestive tract" EXACT [] synonym: "wall of gut" EXACT [FMA:45653] xref: BTO:0000547 xref: FMA:45653 is_a: UBERON:0000060 ! anatomical wall intersection_of: UBERON:0000060 ! anatomical wall intersection_of: BFO:0000050 UBERON:0001555 ! part of digestive tract relationship: BFO:0000050 UBERON:0001555 ! part of digestive tract property_value: skos:prefLabel "gut wall" xsd:string [Term] id: UBERON:0000331 name: ileal mucosa def: "A mucosa that is part of a ileum [Automatically generated definition]." [OBOL:automatic] subset: human_reference_atlas synonym: "ileal mucous membrane" EXACT [FMA:14956] synonym: "ileum mucosa" EXACT [FMA:14956, OBOL:automatic] synonym: "ileum mucosa of organ" EXACT [OBOL:automatic] synonym: "ileum mucous membrane" EXACT [OBOL:automatic] synonym: "ileum organ mucosa" EXACT [OBOL:automatic] synonym: "mucosa of ileum" EXACT [OBOL:automatic] synonym: "mucosa of organ of ileum" EXACT [OBOL:automatic] synonym: "mucous membrane of ileum" EXACT [OBOL:automatic] synonym: "organ mucosa of ileum" EXACT [OBOL:automatic] xref: BTO:0000619 xref: CALOHA:TS-0470 xref: EMAPA:35424 xref: FMA:14956 xref: MA:0003216 xref: SCTID:85458007 is_a: UBERON:0001204 ! mucosa of small intestine intersection_of: UBERON:0000344 ! mucosa intersection_of: BFO:0000050 UBERON:0002116 ! part of ileum relationship: BFO:0000050 UBERON:0002116 ! part of ileum property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0000332 name: yellow bone marrow def: "Bone marrow in which the fat cells predominate in the meshes of the reticular network." [http://medical-dictionary.thefreedictionary.com/Yellow+Marrow] synonym: "fat marrow" RELATED [BTO:0000635] synonym: "medulla ossium flava" EXACT OMO:0003011 [BTO:0000635] synonym: "yellow marrow" EXACT [BTO:0000635] xref: BTO:0000635 xref: FMA:74596 xref: SCTID:328639002 xref: SCTID:5023006 is_a: BFO:0000002 is_a: UBERON:0002371 ! bone marrow intersection_of: UBERON:0002371 ! bone marrow intersection_of: RO:0002473 CL:0000136 ! composed primarily of adipocyte relationship: BFO:0000050 UBERON:0007195 ! part of stroma of bone marrow relationship: RO:0002473 CL:0000136 ! composed primarily of adipocyte [Term] id: UBERON:0000333 name: intestinal gland def: "A gland that is part of the intestinal mucosa. Examples include the intestinal crypts, duodenal gland[cjm]." [https://orcid.org/0000-0002-6601-2165] subset: organ_slim synonym: "bowel mucosa gland" EXACT [OBOL:automatic] synonym: "bowel mucosa of organ gland" EXACT [OBOL:automatic] synonym: "bowel mucous membrane gland" EXACT [OBOL:automatic] synonym: "bowel organ mucosa gland" EXACT [OBOL:automatic] synonym: "gland of bowel mucosa" EXACT [OBOL:automatic] synonym: "gland of bowel mucosa of organ" EXACT [OBOL:automatic] synonym: "gland of bowel mucous membrane" EXACT [OBOL:automatic] synonym: "gland of bowel organ mucosa" EXACT [OBOL:automatic] synonym: "gland of intestinal mucosa" EXACT [OBOL:automatic] synonym: "gland of intestine mucosa" EXACT [OBOL:automatic] synonym: "gland of intestine mucosa of organ" EXACT [OBOL:automatic] synonym: "gland of intestine mucous membrane" EXACT [OBOL:automatic] synonym: "gland of intestine organ mucosa" EXACT [OBOL:automatic] synonym: "gland of mucosa of bowel" EXACT [OBOL:automatic] synonym: "gland of mucosa of intestine" EXACT [OBOL:automatic] synonym: "gland of mucosa of organ of bowel" EXACT [OBOL:automatic] synonym: "gland of mucosa of organ of intestine" EXACT [OBOL:automatic] synonym: "gland of mucous membrane of bowel" EXACT [OBOL:automatic] synonym: "gland of mucous membrane of intestine" EXACT [OBOL:automatic] synonym: "gland of organ mucosa of bowel" EXACT [OBOL:automatic] synonym: "gland of organ mucosa of intestine" EXACT [OBOL:automatic] synonym: "glandula intestinalis" EXACT [FMA:15052] synonym: "glandulae intestinales" RELATED [] synonym: "intestinal mucosa gland" EXACT [OBOL:automatic] synonym: "intestine mucosa gland" EXACT [OBOL:automatic] synonym: "intestine mucosa of organ gland" EXACT [OBOL:automatic] synonym: "intestine mucous membrane gland" EXACT [OBOL:automatic] synonym: "intestine organ mucosa gland" EXACT [OBOL:automatic] synonym: "mucosa of bowel gland" EXACT [OBOL:automatic] synonym: "mucosa of intestine gland" EXACT [OBOL:automatic] synonym: "mucosa of organ of bowel gland" EXACT [OBOL:automatic] synonym: "mucosa of organ of intestine gland" EXACT [OBOL:automatic] synonym: "mucous membrane of bowel gland" EXACT [OBOL:automatic] synonym: "mucous membrane of intestine gland" EXACT [OBOL:automatic] synonym: "organ mucosa of bowel gland" EXACT [OBOL:automatic] synonym: "organ mucosa of intestine gland" EXACT [OBOL:automatic] xref: BTO:0000640 xref: FMA:15052 xref: SCTID:266297002 is_a: UBERON:0003408 ! gland of digestive tract intersection_of: UBERON:0002530 ! gland intersection_of: BFO:0000050 UBERON:0001242 ! part of intestinal mucosa relationship: BFO:0000050 UBERON:0001242 ! part of intestinal mucosa property_value: skos:prefLabel "intestinal gland" xsd:string [Term] id: UBERON:0000344 name: mucosa def: "A lining of mostly endodermal origin, covered in epithelium, which is involved in absorption and secretion. They line various body cavities that are exposed to the external environment and internal organs. It is at several places continuous with skin: at the nostrils, the lips, the ears, the genital area, and the anus. The sticky, thick fluid secreted by the mucous membranes and gland is termed mucus. The term mucous membrane refers to where they are found in the body and not every mucous membrane secretes mucus[WP]." [Wikipedia:Mucous_membrane] subset: pheno_slim synonym: "mucosa of organ" EXACT [FMA:85355] synonym: "mucosa of organ part" EXACT [FMA:85358] synonym: "mucosal region" EXACT [FMA:85358] synonym: "mucous membrane" EXACT [FMA:85355] synonym: "organ mucosa" EXACT [FMA:85355] synonym: "region of mucosa" RELATED [FMA:85358] synonym: "tunica mucosa" RELATED OMO:0003011 [BTO:0000886, Wikipedia:Mucous_membrane] xref: AEO:0000199 xref: BTO:0000886 xref: CALOHA:TS-2031 xref: EHDAA2_RETIRED:0003234 xref: EV:0100382 xref: FMA:85355 xref: FMA:85358 xref: GAID:297 xref: galen:Mucosa xref: MESH:D009092 xref: NCIT:C13166 xref: SCTID:361693009 xref: UMLS:C0026724 {source="ncithesaurus:Mucosa"} xref: Wikipedia:Mucous_membrane is_a: UBERON:0004923 ! organ component layer relationship: BFO:0000051 UBERON:0000483 ! has part epithelium relationship: BFO:0000051 UBERON:0002384 ! has part connective tissue relationship: RO:0002162 NCBITaxon:7711 ! in taxon Chordata property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/4/4e/Ens.png" xsd:anyURI property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/en/thumb/4/4e/Ens.png/200px-Ens.png" xsd:anyURI property_value: skos:prefLabel "mucosa" xsd:string [Term] id: UBERON:0000348 name: ophthalmic nerve def: "The sensory nerve subdivision of the trigeminal nerve that transmits sensory information from the orbit and its contents, the nasal cavity and the skin of the nose and forehead." [MP:0009798, Wikipedia:Ophthalmic_nerve] comment: Terminology notes. This nerve is known by a ridiculous number of names[http://palaeos.com/vertebrates/glossary/glossaryPo.html] subset: human_reference_atlas subset: pheno_slim synonym: "ciliary nerve" RELATED [http://palaeos.com/vertebrates/glossary/glossaryPo.html] synonym: "cranial nerve V, branch V1" EXACT [http://orcid.org/0000-0002-6601-2165] synonym: "ethmoidal nerve" RELATED [Wikipedia:Ophthalmic_nerve] synonym: "first branch of fifth cranial nerve" EXACT [http://orcid.org/0000-0002-6601-2165] synonym: "first division of fifth cranial nerve" EXACT [FMA:52621] synonym: "first division of trigeminal nerve" EXACT [FMA:52621] synonym: "nervus ophthalmicus (V1)" EXACT [FMA:52621] synonym: "nervus ophthalmicus (Va)" EXACT [FMA:52621] synonym: "nervus ophthalmicus [v1]" EXACT OMO:0003011 [FMA:52621, FMA:TA] synonym: "nervus ophthalmicus [va]" EXACT OMO:0003011 [FMA:52621, FMA:TA] synonym: "ophthalmic division" RELATED [BTO:0000926, Wikipedia:Ophthalmic_nerve] synonym: "ophthalmic division [V1]" EXACT [FMA:52621] synonym: "ophthalmic division [Va]" EXACT [FMA:52621] synonym: "ophthalmic division of fifth cranial nerve" EXACT [FMA:52621] synonym: "ophthalmic division of trigeminal nerve (V1)" EXACT [FMA:52621] synonym: "ophthalmic division of trigeminal nerve (Va)" EXACT [FMA:52621] synonym: "ophthalmic nerve [V1]" EXACT [FMA:52621] synonym: "ophthalmic nerve [Va]" EXACT [FMA:52621] synonym: "opthalmic nerve" EXACT [Wikipedia:Ophthalmic_nerve] synonym: "profundal nerve" RELATED [http://orcid.org/0000-0002-6601-2165] synonym: "profundus" RELATED [http://palaeos.com/vertebrates/glossary/glossaryPo.html] synonym: "profundus nerve" RELATED [http://palaeos.com/vertebrates/glossary/glossaryPo.html] synonym: "ramus opthalmicus profundus (ramus V1)" EXACT [AAO:0010648] synonym: "rostral branch of trigeminal nerve" EXACT [http://orcid.org/0000-0002-6601-2165] synonym: "trigeminal nerve ophthalmic division" RELATED [EMAPA:17800] synonym: "trigeminal V nerve ophthalmic division" EXACT [MA:0001104] xref: AAO:0010648 xref: BTO:0000926 xref: EHDAA2:0002088 xref: EHDAA:3744 xref: EMAPA:17800 xref: FMA:52621 xref: GAID:837 xref: MA:0001104 xref: MESH:D009882 xref: NCIT:C33215 xref: SCTID:280210000 xref: UMLS:C0029082 {source="ncithesaurus:Ophthalmic_Nerve"} xref: VHOG:0001349 xref: Wikipedia:Ophthalmic_nerve is_a: UBERON:0004121 ! ectoderm-derived structure is_a: UBERON:0011779 ! nerve of head region relationship: RO:0002134 UBERON:1000021 ! innervates skin of face relationship: RO:0002202 UBERON:0035597 ! develops from profundal placode relationship: RO:0002380 UBERON:0001645 ! branching part of trigeminal nerve property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0000349 name: limbic system def: "A set of midline structures surrounding the brainstem of the mammalian brain, originally described anatomically, e.g., hippocampal formation, amygdala, hypothalamus, cingulate cortex. Although the original designation was anatomical, the limbic system has come to be associated with the system in the brain subserving emotional functions. As such, it is very poorly defined and doesn't correspond closely to the anatomical meaning any longer. [BirnLex]." [BIRNLEX:Limbic_system, Wikipedia:Limbic_system] comment: includes the hippocampus, amygdala, anterior thalamic nuclei, and limbic cortex, which support a variety of functions including emotion, behavior, long term memory, and olfaction [Wikipedia] subset: non_informative subset: pheno_slim synonym: "visceral brain" RELATED [ISBN:0123813611] xref: BTO:0000928 xref: CALOHA:TS-1307 xref: FMA:242000 xref: GAID:615 xref: MESH:D008032 xref: NCIT:C94541 xref: neuronames:2055 xref: SCTID:361342009 xref: UMLS:C0023715 {source="ncithesaurus:Limbic_System"} xref: Wikipedia:Limbic_system is_a: UBERON:0011216 ! organ system subdivision relationship: BFO:0000050 UBERON:0001890 ! part of forebrain property_value: foaf:depiction "https://upload.wikimedia.org/wikipedia/commons/5/5c/Brain_limbicsystem.jpg" xsd:anyURI property_value: IAO:0000116 "obsoletion proposes. The current part_of children were chosen as the intersection of what is stated in wikipedia and in the FMA. NIF: We are including Limbic System because it is still used by neuroscientists and others, but as a data annotation term, it is very poor because it is not a clearly defined entity." xsd:string property_value: skos:prefLabel "limbic system" xsd:string [Term] id: UBERON:0000351 name: nuchal ligament def: "A fibrous membrane, which, in the neck, represents the supraspinal ligaments of the upper vertebrae." [Wikipedia:Nuchal_ligament] synonym: "ligament of neck" EXACT [FMA:13427] synonym: "ligamentum nuchae" EXACT OMO:0003011 [FMA:13427] synonym: "paddywhack" NARROW [NCBITaxon:9895, Wikipedia:Paddywhack] synonym: "paxwax" RELATED [] xref: BTO:0000952 xref: EMAPA:19207 xref: FMA:13427 xref: SCTID:166962007 xref: Wikipedia:Nuchal_ligament is_a: UBERON:0005174 ! dorsal region element is_a: UBERON:0008846 ! skeletal ligament relationship: BFO:0000050 UBERON:0012477 {source="BTO"} ! part of dorsal part of neck relationship: RO:0002371 UBERON:0001676 ! attached to occipital bone relationship: RO:0002371 UBERON:0002413 ! attached to cervical vertebra property_value: RO:0002161 NCBITaxon:9596 property_value: RO:0002175 NCBITaxon:9606 property_value: RO:0002175 NCBITaxon:9608 property_value: RO:0002175 NCBITaxon:9788 property_value: RO:0002175 NCBITaxon:9895 [Term] id: UBERON:0000353 name: parenchyma def: "Functional part of an organ in the body. This is in contrast to the stroma, which refers to the structural tissue of organs, being exactly, connective tissues." [Wikipedia:Parenchyma] xref: EHDAA:3015 xref: EHDAA:3905 xref: EHDAA:3999 xref: EHDAA:4005 xref: EHDAA:6899 xref: EHDAA:6903 xref: EHDAA:6994 xref: EHDAA:8086 xref: EHDAA:9182 xref: EHDAA:9190 xref: EHDAA:9196 xref: EHDAA:9202 xref: FMA:45732 xref: NCIT:C74601 xref: UMLS:C0933845 {source="ncithesaurus:Parenchyma"} xref: Wikipedia:Parenchyma is_a: UBERON:0000064 ! organ part disjoint_from: UBERON:0003891 ! stroma relationship: RO:0002162 NCBITaxon:6072 ! in taxon Eumetazoa relationship: RO:0002215 GO:0032501 ! capable of multicellular organismal process property_value: skos:prefLabel "parenchyma" xsd:string [Term] id: UBERON:0000355 name: pharyngeal mucosa def: "A mucosa that is part of a pharynx [Automatically generated definition]." [OBOL:automatic] synonym: "mucosa of organ of pharynx" EXACT [OBOL:automatic] synonym: "mucosa of pharynx" EXACT [OBOL:automatic] synonym: "mucous membrane of pharynx" EXACT [FMA:55031, OBOL:automatic] synonym: "mucous membrane of the pharynx" RELATED [BTO:0001047] synonym: "organ mucosa of pharynx" EXACT [OBOL:automatic] synonym: "pharynx mucosa" EXACT [OBOL:automatic] synonym: "pharynx mucosa of organ" EXACT [OBOL:automatic] synonym: "pharynx mucous membrane" EXACT [OBOL:automatic] synonym: "pharynx organ mucosa" EXACT [OBOL:automatic] synonym: "tunica mucosa pharyngea" EXACT OMO:0003011 [FMA:55031, FMA:TA] synonym: "tunica mucosa pharyngis" EXACT [] xref: BTO:0001047 xref: EMAPA:26957 xref: FMA:55031 xref: MA:0003143 xref: SCTID:362121003 is_a: UBERON:0004785 ! respiratory system mucosa intersection_of: UBERON:0000344 ! mucosa intersection_of: BFO:0000050 UBERON:0001042 ! part of chordate pharynx relationship: BFO:0000050 UBERON:0001042 ! part of chordate pharynx property_value: skos:prefLabel "pharyngeal mucosa" xsd:string [Term] id: UBERON:0000358 name: blastocyst def: "The mammalian blastocyst is a hollow ball of cells containing two cell types, the inner cell mass and the trophectoderm[GO]." [GO:0001824, Wikipedia:Blastocyst] subset: efo_slim synonym: "blastocystis" RELATED OMO:0003011 [Wikipedia:Blastocyst] synonym: "blastula" RELATED [FMA:83041] xref: BTO:0001099 xref: CALOHA:TS-0076 xref: EFO:0000295 xref: EMAPA:36035 xref: EV:0100394 xref: FMA:83041 xref: GAID:1153 xref: MESH:D001755 xref: NCIT:C13739 xref: SCTID:308837009 xref: UMLS:C1281743 {source="ncithesaurus:Blastocyst"} xref: Wikipedia:Blastocyst is_a: BFO:0000002 is_a: UBERON:0002050 ! embryonic structure relationship: BFO:0000050 UBERON:0000307 ! part of blastula relationship: BFO:0000051 UBERON:0000087 ! has part inner cell mass relationship: BFO:0000051 UBERON:0000088 ! has part trophoblast relationship: RO:0002202 UBERON:0000085 ! develops from morula relationship: RO:0002491 UBERON:0000108 ! existence starts and ends during blastula stage property_value: foaf:depiction "https://upload.wikimedia.org/wikipedia/commons/7/72/Blastocyst_English.svg" xsd:anyURI property_value: IAO:0000116 "Gilbert fig11.32 has blastocyst has giving rise to ICM and trophoblast (which in this source is a synonym for trophectoderm)" xsd:string property_value: skos:prefLabel "blastocyst" xsd:string [Term] id: UBERON:0000361 name: red bone marrow def: "The red vascular substance consisting of connective tissue and blood vessels, containing primitive blood cells, macrophages, megakaryocytes, and fat cells. Red marrow is found in the cavities of many bones. It manufactures and releases leukocytes and erythrocytes into the bloodstream." [http://medical-dictionary.thefreedictionary.com/red+marrow] synonym: "medulla ossium rubra" EXACT OMO:0003011 [BTO:0001160] synonym: "parenchyma of none marrow marrow" RELATED [http://orcid.org/0000-0002-6601-2165] synonym: "parenchymal red marrow" EXACT [http://orcid.org/0000-0002-6601-2165] synonym: "red marrow" EXACT [BTO:0001160] xref: BTO:0001160 xref: FMA:74595 xref: SCTID:328538003 xref: SCTID:75330005 is_a: UBERON:0002371 ! bone marrow intersection_of: UBERON:0002371 ! bone marrow intersection_of: RO:0002473 CL:0000988 ! composed primarily of hematopoietic cell relationship: BFO:0000050 UBERON:0012429 ! part of hematopoietic tissue relationship: RO:0002473 CL:0000988 ! composed primarily of hematopoietic cell [Term] id: UBERON:0000362 name: renal medulla def: "The inner portion of the kidney consisting of the renal pyramids." [ISBN:0-683-40008-8, MGI:smb, MP:0003014] comment: Note that 'renal medulla' is not synonymous with 'medullary region of kidney'. The former is composed of kidney pyramids only, while the latter covers kidney pyramids and renal columns, which are histologically different. subset: human_reference_atlas subset: pheno_slim synonym: "kidney medulla" EXACT [OBOL:automatic] synonym: "medulla of kidney" EXACT [OBOL:automatic] synonym: "medulla renalis" EXACT OMO:0003011 [FMA:74268, FMA:TA] synonym: "medullary pyramids" RELATED OMO:0003004 [FMA:74268] synonym: "pyramides renales" EXACT OMO:0003011 [FMA:74268, FMA:TA] synonym: "renal marrow" RELATED [BTO:0001167] synonym: "renal medullae" EXACT OMO:0003004 [FMA:86327] synonym: "renal medullae set" EXACT OMO:0003004 [FMA:86327] synonym: "renal pyramids" EXACT OMO:0003004 [FMA:74268] synonym: "renal pyramids set" EXACT OMO:0003004 [FMA:74268] xref: BTO:0001167 xref: CALOHA:TS-1157 xref: EMAPA:19279 xref: GAID:425 xref: galen:MedullaOfKidney xref: MA:0000373 xref: MESH:D007679 xref: NCIT:C12740 xref: SCTID:30737000 xref: UMLS:C0022664 {source="ncithesaurus:Renal_Medulla"} xref: Wikipedia:Renal_medulla is_a: UBERON:0000958 ! medulla of organ intersection_of: UBERON:0000958 ! medulla of organ intersection_of: BFO:0000050 UBERON:0002113 ! part of kidney relationship: BFO:0000050 UBERON:0002113 ! part of kidney relationship: BFO:0000051 UBERON:0004200 ! has part kidney pyramid relationship: RO:0002216 GO:0070295 ! capable of part of renal water absorption relationship: RO:0002433 UBERON:0002113 ! contributes to morphology of kidney property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/kidney-female-left/v1.3/assets/3d-vh-f-kidney-l.glb" xsd:anyURI property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/kidney-female-right/v1.3/assets/3d-vh-f-kidney-r.glb" xsd:anyURI property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/kidney-male-left/v1.3/assets/3d-vh-m-kidney-l.glb" xsd:anyURI property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/kidney-male-right/v1.3/assets/3d-vh-m-kidney-r.glb" xsd:anyURI property_value: foaf:depiction "https://upload.wikimedia.org/wikipedia/commons/6/69/Illu_kidney.jpg" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0000365 name: urothelium def: "An epithelial tissue layer that lines much of the urinary tract, including the renal pelvis, the ureters, the bladder, and parts of the urethra." [https://github.com/obophenotype/uberon/issues/92, Wikipedia:Urothelium] subset: pheno_slim synonym: "epithelium transitionale" EXACT [FMA:63914] synonym: "transitional epithelium" BROAD INCONSISTENT [] synonym: "transitional epithelium" EXACT [FMA:63914, https://github.com/obophenotype/uberon/issues/92] synonym: "uroepithelium" EXACT [FMA:67695] xref: BTO:0003906 xref: CALOHA:TS-1096 xref: EMAPA:37978 {source="MA:th"} xref: FMA:63914 xref: FMA:67695 xref: GAID:935 xref: MESH:D019459 xref: NCIT:C12884 xref: SCTID:30117005 xref: SCTID:57789003 xref: UMLS:C0225339 {source="ncithesaurus:Transitional_Epithelium"} xref: UMLS:C0227598 {source="ncithesaurus:Urothelium"} xref: Wikipedia:Transitional_epithelium xref: Wikipedia:Urothelium is_a: UBERON:0000486 ! multilaminar epithelium is_a: UBERON:0005911 ! endo-epithelium relationship: BFO:0000050 UBERON:0001008 ! part of renal system property_value: foaf:depiction "https://upload.wikimedia.org/wikipedia/commons/9/91/Harnblase_Urothel.png" xsd:anyURI [Term] id: UBERON:0000369 name: corpus striatum def: "The corpus striatum (striated body) is a compound structure consisting of the caudate nucleus and the lentiform nucleus, which consists of the putamen and the globus pallidus[WP]." [Wikipedia:Corpus_striatum] comment: * According to the 1917 version of Gray's Anatomy, it is the combination of the lentiform nucleus (also known as the lenticular nucleus) and the caudate nucleus * According to BrainInfo it is a part of the basal ganglia comprising the globus pallidus and striatum subset: efo_slim synonym: "striate body" RELATED [BTO:0001311] synonym: "striated body" RELATED [BTO:0001311] xref: BAMS:CSTR xref: BTO:0001311 xref: CALOHA:TS-0183 xref: EFO:0000381 xref: EHDAA2:0000596 xref: EMAPA:17549 xref: EV:0100184 xref: FMA:77616 xref: GAID:667 xref: MESH:D003342 xref: NCIT:C12448 xref: neuronames:2339 xref: SCTID:279318005 xref: UMLS:C0010097 {source="ncithesaurus:Corpus_Striatum"} xref: VHOG:0001175 xref: Wikipedia:Corpus_striatum is_a: UBERON:0002616 ! regional part of brain relationship: BFO:0000050 UBERON:0002420 {source="MA"} ! part of basal ganglion property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/b/b3/Gray656.png" xsd:anyURI property_value: skos:prefLabel "corpus striatum" xsd:string [Term] id: UBERON:0000371 name: syncytiotrophoblast def: "Extraembryonic cells of trophoblastic shell surrounding embryo, outside the cytotrophoblast layer, involved with implantation of the blastocyst by eroding extracellular matrix surrounding maternal endometrial cells at site of implantation, also contribute to villi. (dark staining, multinucleated)." [http://embryology.med.unsw.edu.au/Notes/placenta5.htm, Wikipedia:Syncytiotrophoblast] synonym: "syncitiotrophoblast" RELATED [] synonym: "syncitiotrophoblastus" RELATED OMO:0003011 [Wikipedia:Syncytiotrophoblast] synonym: "syncytial trophoblast" EXACT [FMA:83040] synonym: "syntrophoblast" RELATED [] synonym: "syntrophoblast layer" EXACT [ISBN:0073040584] xref: BTO:0001335 xref: EHDAA:129 xref: EHDAA:91 xref: EMAPA:16068 xref: FMA:83040 xref: NCIT:C33918 xref: SCTID:256965005 xref: UMLS:C1135936 {source="ncithesaurus:Syncytiotrophoblast"} xref: Wikipedia:Syncytiotrophoblast is_a: BFO:0000002 is_a: UBERON:0002050 {source="FMA"} ! embryonic structure relationship: BFO:0000050 UBERON:0004364 {source="EMAPA"} ! part of ectoplacental cone relationship: RO:0002473 CL:0000525 ! composed primarily of syncytiotrophoblast cell property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/d/df/Gray36.png" xsd:anyURI [Term] id: UBERON:0000375 name: mandibular nerve def: "The motor and sensory nerve subdivision of the trigeminal nerve that transmits sensory information from the auricle, the external acoustic meatus, tympanic membrane, temporal region, the cheek, the skin overlying the mandible, the anterior portion of the tongue, the floor of the mouth, lower teeth and gingiva and transmits motor information from the muscles of mastication, the mylohyoid muscle and digastric muscle and the muscles tensor tympani and tensor veli palatini." [MP:0009800, Wikipedia:Mandibular_nerve] subset: human_reference_atlas subset: pheno_slim synonym: "inferior maxillary nerve" EXACT [FMA:52996] synonym: "mandibular division [V3]" EXACT [FMA:52996] synonym: "mandibular division [Vc]" EXACT [FMA:52996] synonym: "mandibular division of fifth cranial nerve" EXACT [FMA:52996] synonym: "mandibular division of trigeminal nerve [Vc; V3]" EXACT [FMA:52996] synonym: "mandibular nerve [V3]" EXACT [FMA:52996] synonym: "mandibular nerve [Vc]" EXACT [FMA:52996] synonym: "n. mandibularis" RELATED OMO:0003011 [Wikipedia:Mandibular_nerve] synonym: "nervus mandibularis" RELATED [BTO:0001375] synonym: "nervus mandibularis [v3]" EXACT OMO:0003011 [FMA:52996, FMA:TA] synonym: "nervus mandibularis [Vc; V3]" EXACT [FMA:52996] synonym: "nervus mandibularis [vc]" EXACT OMO:0003011 [FMA:52996, FMA:TA] synonym: "ramus mandibularis (ramus V3)" EXACT [AAO:0010688] synonym: "third division of fifth cranial nerve" EXACT [FMA:52996] synonym: "third division of trigeminal nerve" EXACT [FMA:52996] synonym: "trigeminal nerve mandibular division" RELATED [EMAPA:17798] synonym: "trigeminal V nerve mandibular division" EXACT [MA:0001101] xref: AAO:0010688 xref: AAO:0010703 xref: BTO:0001375 xref: EHDAA2:0002086 xref: EMAPA:17798 xref: FMA:52996 xref: GAID:834 xref: MA:0001101 xref: MESH:D008340 xref: NCIT:C32779 xref: SCTID:280212008 xref: UMLS:C0024695 {source="ncithesaurus:Inferior_Maxillary_Nerve"} xref: VHOG:0001345 xref: Wikipedia:Mandibular_nerve is_a: UBERON:0011779 ! nerve of head region relationship: RO:0002380 UBERON:0001645 ! branching part of trigeminal nerve property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/4/4d/Gray781.png" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "mandibular nerve" xsd:string [Term] id: UBERON:0000376 name: hindlimb stylopod def: "The part of the hindlimb between pelvis and the knee, corresponding to the femur." [http://orcid.org/0000-0002-6601-2165] subset: efo_slim subset: pheno_slim synonym: "femur" RELATED OMO:0003011 [Wikipedia:Thigh] synonym: "hind limb stylopod" EXACT [OBOL:automatic] synonym: "hind limb stylopodium" EXACT [VHOG:0000349] synonym: "hind propodium" EXACT [AAO:0000887] synonym: "hindlimb propodium" EXACT [AAO:0000887] synonym: "hindlimb stylopod" EXACT [OBOL:automatic] synonym: "hindlimb stylopodium" EXACT [OBOL:automatic] synonym: "proximal segment of free lower limb" EXACT [FMA:24967] synonym: "stylopod of hind limb" EXACT [OBOL:automatic] synonym: "stylopod of hindlimb" EXACT [OBOL:automatic] synonym: "stylopod of lower limb" EXACT [] synonym: "thigh" EXACT [] synonym: "upper leg" EXACT HUMAN_PREFERRED [MA:0000052] xref: BTO:0001376 xref: CALOHA:TS-2039 xref: EFO:0001943 xref: EHDAA2:0002130 xref: EHDAA:5171 xref: EHDAA:6200 xref: EMAPA:17499 xref: FMA:24967 xref: GAID:50 xref: galen:Thigh xref: MA:0000052 xref: MESH:D013848 xref: NCIT:C33763 xref: SCTID:302544002 xref: UMLS:C0039866 {source="ncithesaurus:Thigh"} xref: VHOG:0000349 xref: Wikipedia:Thigh is_a: UBERON:0002472 ! stylopod is_a: UBERON:0008784 ! lower limb segment intersection_of: UBERON:0002472 ! stylopod intersection_of: BFO:0000050 UBERON:0002103 ! part of hindlimb relationship: BFO:0000050 UBERON:0000978 {source="MA"} ! part of leg relationship: RO:0002433 UBERON:0002103 ! contributes to morphology of hindlimb relationship: RO:0002551 UBERON:0015052 ! has skeleton femur endochondral element property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/4/4b/Gray1238.png" xsd:anyURI [Term] id: UBERON:0000377 name: maxillary nerve def: "The sensory nerve subdivision of the trigeminal nerve that transmits sensory information from the palate, upper teeth and gingiva, the skin between the palpebral fissure and the mouth, and from the nasal cavity and maxillary sinuses." [MP:0009799, Wikipedia:Maxillary_nerve] subset: human_reference_atlas subset: pheno_slim synonym: "maxillary division [V2]" EXACT [FMA:52724] synonym: "maxillary division [Vb]" EXACT [FMA:52724] synonym: "maxillary division of fifth cranial nerve" EXACT [FMA:52724] synonym: "maxillary division of trigeminal nerve (Vb; V2)" EXACT [FMA:52724] synonym: "maxillary nerve [V2]" EXACT [FMA:52724] synonym: "maxillary nerve [Vb]" EXACT [FMA:52724] synonym: "n. maxillaris" RELATED OMO:0003011 [Wikipedia:Maxillary_nerve] synonym: "nervus maxillaris" RELATED [BTO:0001378] synonym: "nervus maxillaris (Vb; V2)" EXACT [FMA:52724] synonym: "nervus maxillaris [v2]" EXACT OMO:0003011 [FMA:52724, FMA:TA] synonym: "nervus maxillaris [vb]" EXACT OMO:0003011 [FMA:52724, FMA:TA] synonym: "ramus maxillaris (ramus V2)" EXACT [AAO:0010670] synonym: "second division of fifth cranial nerve" EXACT [FMA:52724] synonym: "second division of trigeminal nerve" EXACT [FMA:52724] synonym: "trigeminal nerve maxillary division" RELATED [EMAPA:17799] synonym: "trigeminal V nerve maxillary division" EXACT [MA:0001103] xref: AAO:0010670 xref: BTO:0001378 xref: EHDAA2:0002087 xref: EMAPA:17799 xref: FMA:52724 xref: GAID:836 xref: MA:0001103 xref: MESH:D008442 xref: SCTID:280211001 xref: VHOG:0001346 xref: Wikipedia:Maxillary_nerve is_a: UBERON:0011779 ! nerve of head region relationship: RO:0002380 UBERON:0001645 ! branching part of trigeminal nerve property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/a/a9/Gray779.png" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "maxillary nerve" xsd:string [Term] id: UBERON:0000378 name: tongue muscle def: "The muscular portion of the tongue." [MP:0004136, Wikipedia:Muscles_of_tongue] subset: pheno_slim synonym: "muscle of tongue" EXACT [FMA:46689] synonym: "muscle organ of tongue" EXACT [OBOL:accepted] synonym: "musculi linguae" RELATED OMO:0003011 [Wikipedia:Muscles_of_tongue] synonym: "skeletal muscle tissue of tongue" EXACT [OBOL:automatic] synonym: "tongue skeletal muscle" EXACT [OBOL:automatic] synonym: "tongue skeletal muscle tissue" EXACT [OBOL:automatic] xref: BTO:0001386 xref: EHDAA2:0002065 xref: EHDAA:9146 xref: EMAPA:17883 xref: FMA:46689 xref: MA:0001596 xref: NCIT:C49301 xref: NCIT:C52707 xref: SCTID:244781004 xref: UMLS:C0448325 {source="ncithesaurus:Tongue_Muscle"} xref: UMLS:C1710437 {source="ncithesaurus:Tongue_Skeletal_Muscle_Tissue"} xref: VHOG:0001390 xref: Wikipedia:Muscles_of_tongue is_a: UBERON:0013765 ! digestive system element is_a: UBERON:0014892 {source="FEED:rd"} ! skeletal muscle organ, vertebrate intersection_of: UBERON:0014892 ! skeletal muscle organ, vertebrate intersection_of: RO:0002177 UBERON:0001723 ! attached to part of tongue union_of: UBERON:0001575 ! extrinsic muscle of tongue union_of: UBERON:0001576 ! intrinsic muscle of tongue relationship: BFO:0000050 UBERON:0000165 ! part of mouth relationship: RO:0002177 UBERON:0001723 ! attached to part of tongue relationship: RO:0002202 UBERON:0005594 {source="FEED:rd", source="ISBN:1607950324"} ! develops from head somite relationship: RO:0002433 UBERON:0001723 ! contributes to morphology of tongue property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/c/c6/Gray1019.png" xsd:anyURI property_value: skos:prefLabel "tongue muscle" xsd:string [Term] id: UBERON:0000379 name: tracheal mucosa def: "A mucosa that is part of a trachea." [OBOL:automatic] synonym: "mucosa of organ of trachea" EXACT [OBOL:automatic] synonym: "mucosa of organ of windpipe" EXACT [OBOL:automatic] synonym: "mucosa of trachea" EXACT [OBOL:automatic] synonym: "mucosa of windpipe" EXACT [OBOL:automatic] synonym: "mucous membrane of trachea" EXACT [FMA:7471, OBOL:automatic] synonym: "mucous membrane of windpipe" EXACT [OBOL:automatic] synonym: "organ mucosa of trachea" EXACT [OBOL:automatic] synonym: "organ mucosa of windpipe" EXACT [OBOL:automatic] synonym: "trachea mucosa" EXACT [OBOL:automatic] synonym: "trachea mucosa of organ" EXACT [OBOL:automatic] synonym: "trachea mucous membrane" EXACT [OBOL:automatic] synonym: "trachea organ mucosa" EXACT [OBOL:automatic] synonym: "tracheal mucous membrane" EXACT [FMA:7471] synonym: "tunica mucosa (tracheae)" EXACT [FMA:7471] synonym: "tunica mucosa tracheae" EXACT OMO:0003011 [FMA:7471, FMA:TA] synonym: "windpipe mucosa" EXACT [OBOL:automatic] synonym: "windpipe mucosa of organ" EXACT [OBOL:automatic] synonym: "windpipe mucous membrane" EXACT [OBOL:automatic] synonym: "windpipe organ mucosa" EXACT [OBOL:automatic] xref: BTO:0001390 xref: FMA:7471 xref: SCTID:660006 is_a: UBERON:0004785 ! respiratory system mucosa intersection_of: UBERON:0000344 ! mucosa intersection_of: BFO:0000050 UBERON:0003126 ! part of trachea relationship: BFO:0000050 UBERON:0003126 ! part of trachea property_value: skos:prefLabel "tracheal mucosa" xsd:string [Term] id: UBERON:0000382 name: apocrine sweat gland def: "Apocrine sweat glands are sweat glands composed of a coiled secretory portion located at the junction of the dermis and subcutaneous fat, from which a straight portion inserts and secretes into the infundibular portion of the hair follicle. The ducts of apocrine glands open into the canals of hair follicles. The stimulus for the secretion of apocrine sweat glands is adrenaline, which is a hormone carried in the blood[WP]." [PMID:18489347, Wikipedia:Apocrine_sweat_gland] subset: organ_slim subset: pheno_slim synonym: "glandula sudorifera apocrina" EXACT OMO:0003011 [Wikipedia:Apocrine_sweat_gland] xref: BTO:0001458 xref: EMAPA:37426 {source="MA:th"} xref: FMA:59155 xref: MESH:D001050 xref: NCIT:C32132 xref: SCTID:399916008 xref: UMLS:C0930083 {source="ncithesaurus:Apocrine_Sweat_Gland"} xref: Wikipedia:Apocrine_sweat_gland is_a: UBERON:0001820 {source="FMA"} ! sweat gland is_a: UBERON:0012177 ! skin apocrine gland disjoint_from: UBERON:0000423 ! eccrine sweat gland property_value: RO:0002161 NCBITaxon:9822 {source="http://www.nal.usda.gov/awic/pubs/swine/swine.htm"} property_value: seeAlso "https://github.com/obophenotype/uberon/issues/2111" xsd:string [Term] id: UBERON:0000383 name: musculature of body def: "The subdivision of the musculoskeletal system that consists of all the muscles of the body[VSAO, modified]." [VSAO:0000033] subset: efo_slim subset: human_reference_atlas subset: pheno_slim synonym: "muscle system" EXACT [] synonym: "muscle system of body" EXACT [] synonym: "muscular system" EXACT [FMA:72954] synonym: "musculature system" EXACT [BILA:0000088] synonym: "muskelsystem" RELATED [BTO:0001485] synonym: "set of all muscles" EXACT [FMA:72954] synonym: "set of muscles of body" EXACT [FMA:72954] synonym: "vertebrate muscular system" EXACT [BTO:0001369] xref: AAO:0000307 xref: BILA:0000088 xref: BTO:0001369 xref: BTO:0001485 xref: EFO:0000801 xref: FMA:72954 xref: MA:0002888 xref: MAT:0000025 xref: MIAA:0000025 xref: VSAO:0000033 xref: XAO:0004042 is_a: BFO:0000002 is_a: UBERON:0011216 ! organ system subdivision intersection_of: UBERON:0011216 ! organ system subdivision intersection_of: RO:0002473 UBERON:0001015 ! composed primarily of musculature relationship: RO:0002215 GO:0003012 ! capable of muscle system process relationship: RO:0002473 UBERON:0001015 ! composed primarily of musculature property_value: IAO:0000116 "consider whether this should be restricted to skeletal musculature. See https://github.com/obophenotype/uberon/issues/77" xsd:string property_value: RO:0002161 NCBITaxon:6040 property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "musculature of body" xsd:string [Term] id: UBERON:0000389 name: lens cortex def: "Tissue that surrounds the lens nucleus." [http://www.thefreedictionary.com/lens+cortex] subset: human_reference_atlas synonym: "cortex of lens" EXACT [FMA:58970] xref: BTO:0001632 xref: CALOHA:TS-0542 xref: FMA:58970 xref: MESH:D007904 xref: SCTID:280626006 is_a: UBERON:0000479 ! tissue is_a: UBERON:0004121 ! ectoderm-derived structure intersection_of: UBERON:0000479 ! tissue intersection_of: RO:0002221 UBERON:0000390 ! surrounds lens nucleus relationship: BFO:0000050 UBERON:0000965 ! part of lens of camera-type eye relationship: RO:0002202 UBERON:0005614 ! develops from lens anterior epithelium relationship: RO:0002221 UBERON:0000390 ! surrounds lens nucleus property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "lens cortex" xsd:string [Term] id: UBERON:0000390 name: lens nucleus def: "The core of the crystalline lens, surrounded by the cortex." [BTO:0001633] subset: human_reference_atlas synonym: "nucleus of lens" EXACT [FMA:58971] xref: BTO:0001633 xref: FMA:58971 xref: MESH:D007907 xref: SCTID:280628007 is_a: UBERON:0004121 ! ectoderm-derived structure is_a: UBERON:0034944 ! zone of organ intersection_of: UBERON:0034944 ! zone of organ intersection_of: RO:0002219 UBERON:0000389 ! surrounded by lens cortex relationship: BFO:0000050 UBERON:0000965 ! part of lens of camera-type eye relationship: RO:0002202 UBERON:0005614 ! develops from lens anterior epithelium relationship: RO:0002219 UBERON:0000389 ! surrounded by lens cortex property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "lens nucleus" xsd:string [Term] id: UBERON:0000391 name: leptomeninx def: "Pia mater or arachnoid mater." [https://github.com/obophenotype/uberon/issues/300, Wikipedia:Leptomeninges] subset: organ_slim synonym: "arachnoid mater and pia mater" RELATED [FMA:231515] synonym: "arachnoidea mater et pia mater" RELATED [BTO:0001634] synonym: "leptomeninges" EXACT OMO:0003004 [NLXANAT:090207] synonym: "pia-arachnoid" RELATED [BTO:0001634] synonym: "pia-arachnoid of neuraxis" RELATED [FMA:231515] xref: BTO:0001634 xref: CALOHA:TS-0546 xref: FMA:231515 xref: NCIT:C32979 xref: neuronames:2347 xref: NLXANAT:090207 xref: SCTID:362303006 xref: UMLS:C0228126 {source="ncithesaurus:Leptomeninges"} xref: Wikipedia:Leptomeninges is_a: UBERON:0002360 ! meninx relationship: RO:0002495 UBERON:0007646 ! immediate transformation of endomeninx property_value: IAO:0000116 "check relationship to secondary meninx" xsd:string property_value: skos:prefLabel "leptomeninx" xsd:string property_value: terms:contributor https://orcid.org/0000-0002-6601-2165 [Term] id: UBERON:0000395 name: cochlear ganglion def: "The group of nerve cell bodies that conveys auditory sensation from the organ of Corti to the hindbrain and resides on the cochlear part of the vestibulocochlear nerve (eighth cranial nerve)[MP]. distributed to the hair cells of the spiral organ. The cochlear fibers arise in bipolar cells in the spiral ganglion in the modiolus." [http://www.dartmouth.edu/~humananatomy/part_8/chapter_44.html, MP:0002855] subset: pheno_slim synonym: "cochlear part of vestibulocochlear ganglion" EXACT [http://orcid.org/0000-0002-6601-2165] synonym: "Corti's ganglion" EXACT [FMA:53445] synonym: "ganglion cochlearis" RELATED [BTO:0001688] synonym: "ganglion of Corti" EXACT [FMA:53445] synonym: "ganglion spirale" RELATED OMO:0003011 [Wikipedia:Spiral_ganglion] synonym: "ganglion spirale cochleae" RELATED [BTO:0001688] synonym: "spiral ganglion" EXACT [FMA:53445] synonym: "spiral ganglion of cochlea" RELATED [BTO:0001688] synonym: "vestibulocochlear ganglion cochlear component" RELATED [EMAPA:17572] synonym: "vestibulocochlear VIII ganglion cochlear component" EXACT [MA:0001085] xref: BAMS:GcVIII xref: BTO:0001688 xref: EHDAA2:0002198 xref: EMAPA:17572 xref: FMA:53445 xref: GAID:722 xref: MA:0001085 xref: MESH:D013136 xref: neuronames:1405 xref: SCTID:368955007 xref: VHOG:0001183 xref: Wikipedia:Spiral_ganglion is_a: UBERON:0001714 ! cranial ganglion intersection_of: UBERON:0001714 ! cranial ganglion intersection_of: extends_fibers_into UBERON:0004727 ! cochlear nerve relationship: BFO:0000050 UBERON:0002827 ! part of vestibulocochlear ganglion relationship: BFO:0000050 UBERON:0016490 ! part of auditory system relationship: extends_fibers_into UBERON:0004727 ! cochlear nerve relationship: RO:0001025 UBERON:0006723 ! located in cochlear modiolus property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/b/b1/Gray903.png" xsd:anyURI property_value: IAO:0000116 "in BTO this is part of the cochlear modiolus, but this leads to the CG being in both the nervous and skeletal systems" xsd:string property_value: skos:prefLabel "cochlear ganglion" xsd:string [Term] id: UBERON:0000397 name: colonic epithelium def: "An epithelium that is part of a colon [Automatically generated definition]." [OBOL:automatic] subset: human_reference_atlas subset: vertebrate_core synonym: "colon epithelial tissue" EXACT [OBOL:automatic] synonym: "colon epithelium" EXACT [FMA:17302, OBOL:automatic] synonym: "epithelial tissue of colon" EXACT [OBOL:automatic] synonym: "epithelial tissue of large bowel" EXACT [OBOL:automatic] synonym: "epithelium of colon" EXACT [OBOL:automatic] synonym: "epithelium of large bowel" EXACT [OBOL:automatic] synonym: "large bowel epithelial tissue" EXACT [OBOL:automatic] synonym: "large bowel epithelium" EXACT [OBOL:automatic] synonym: "posterior intestine epithelium" EXACT [ZFA:0005128] xref: BTO:0001709 xref: CALOHA:TS-0163 xref: EMAPA:18941 xref: FMA:17302 xref: MA:0003195 xref: SCTID:42978003 xref: TAO:0005128 xref: ZFA:0005128 is_a: UBERON:0001278 ! epithelium of large intestine intersection_of: UBERON:0000483 ! epithelium intersection_of: BFO:0000050 UBERON:0001155 ! part of colon relationship: BFO:0000050 UBERON:0001155 ! part of colon property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "colonic epithelium" xsd:string [Term] id: UBERON:0000398 name: cartilage tissue of sternum def: "Any portion of cartilage tissue that is part of the sternum." [https://orcid.org/0000-0002-6601-2165] comment: Examples: cartilage of manubrium, cartilage of xiphoid process synonym: "cartilage of sternum" EXACT [FMA:32567] xref: FMA:32567 is_a: UBERON:0002418 ! cartilage tissue is_a: UBERON:0003837 ! thoracic segment connective tissue intersection_of: UBERON:0002418 ! cartilage tissue intersection_of: BFO:0000050 UBERON:0000975 ! part of sternum relationship: BFO:0000050 UBERON:0000975 ! part of sternum [Term] id: UBERON:0000399 name: jejunal mucosa def: "A mucosa that is part of a jejunum [Automatically generated definition]." [OBOL:automatic] subset: human_reference_atlas synonym: "jejunal mucous membrane" EXACT [FMA:14949] synonym: "jejunum mucosa" EXACT [FMA:14949] synonym: "jejunum mucosa of organ" EXACT [OBOL:automatic] synonym: "jejunum mucous membrane" EXACT [OBOL:automatic] synonym: "jejunum organ mucosa" EXACT [OBOL:automatic] synonym: "mucosa of jejunum" EXACT [FMA:14949] synonym: "mucosa of organ of jejunum" EXACT [OBOL:automatic] synonym: "mucous membrane of jejunum" EXACT [OBOL:automatic] synonym: "organ mucosa of jejunum" EXACT [OBOL:automatic] xref: BTO:0001742 xref: CALOHA:TS-0495 xref: EMAPA:27109 xref: FMA:14949 xref: MA:0003214 xref: SCTID:362151009 is_a: UBERON:0001204 ! mucosa of small intestine intersection_of: UBERON:0000344 ! mucosa intersection_of: BFO:0000050 UBERON:0002115 ! part of jejunum relationship: BFO:0000050 UBERON:0002115 ! part of jejunum property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0000400 name: jejunal epithelium def: "An epithelium that is part of a jejunum." [OBOL:automatic] subset: human_reference_atlas synonym: "epithelium of jejunum" EXACT [] xref: BTO:0001743 xref: CALOHA:TS-0494 xref: EMAPA:18668 xref: FMA:17232 xref: MA:0003215 xref: SCTID:57300004 is_a: UBERON:0013636 ! epithelium of intestinal villus intersection_of: UBERON:0000483 ! epithelium intersection_of: BFO:0000050 UBERON:0002115 ! part of jejunum relationship: BFO:0000050 UBERON:0008343 {source="FMA"} ! part of intestinal villus of jejunum property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0000402 name: nasal vestibule def: "The nasal vestibule is the most anterior part of the nasal cavity. It's enclosed by the cartilages of nose and lined by the same epithelium of the skin. The other part of the nasal cavity, which is lined by the respiratory epithelium, is called nasal cavity proper. [WP,unvetted]." [Wikipedia:Nasal_vestibule] synonym: "vestibular part of nasal cavity" EXACT [FMA:59644] synonym: "vestibulum nasale" RELATED [BTO:0001761] synonym: "vestibulum nasi" RELATED OMO:0003011 [BTO:0001761, Wikipedia:Nasal_vestibule] xref: BTO:0001761 xref: CALOHA:TS-0660 xref: FMA:59644 xref: SCTID:278940000 xref: Wikipedia:Nasal_vestibule is_a: UBERON:0002553 ! anatomical cavity relationship: BFO:0000050 UBERON:0001707 ! part of nasal cavity property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/7/7c/Gray994.png" xsd:anyURI [Term] id: UBERON:0000403 name: scalp def: "The outer covering of the calvaria. It is composed of several layers: SKIN; subcutaneous connective tissue; the occipitofrontal muscle which includes the tendonous galea aponeurotica; Loose connective tissue; and the pericranium (the PERIOSTEUM of the SKULL)." [MESH:A01.456.810] subset: pheno_slim synonym: "scalpus" RELATED OMO:0003011 [Wikipedia:Scalp] xref: BTO:0001809 xref: CALOHA:TS-0896 xref: EMAPA:37949 {source="MA:th"} xref: FMA:46494 xref: GAID:80 xref: galen:Scalp xref: MESH:D012535 xref: NCIT:C89807 xref: SCTID:181480002 xref: UMLS:C0036270 {source="ncithesaurus:Scalp"} xref: Wikipedia:Scalp is_a: UBERON:0010314 ! structure with developmental contribution from neural crest is_a: UBERON:0034921 ! multi organ part structure relationship: BFO:0000050 UBERON:0000033 {source="BTO"} ! part of head relationship: BFO:0000051 UBERON:0000014 ! has part zone of skin relationship: BFO:0000051 UBERON:0002515 ! has part periosteum relationship: RO:0002131 UBERON:0001084 ! overlaps skin of head relationship: RO:0002131 UBERON:0006661 ! overlaps epicranial aponeurosis property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/5/55/Layers_of_the_scalp_and_meninges.png" xsd:anyURI property_value: foaf:depiction "https://upload.wikimedia.org/wikipedia/commons/e/eb/Double_cowlick.jpg" xsd:anyURI [Term] id: UBERON:0000407 name: sympathetic trunk def: "One of a a paired bundle of nerve fibers plus ganglia that run from the base of the skull to the coccyx." [http://orcid.org/0000-0002-6601-2165, Wikipedia:Sympathetic_trunk] synonym: "gangliated cord" EXACT [Wikipedia:Sympathetic_trunk] synonym: "sympathetic chain" EXACT [FMA:6258] synonym: "sympathetic ganglionic chain" EXACT [Wikipedia:Sympathetic_trunk] synonym: "truncus sympathicus" RELATED OMO:0003011 [Wikipedia:Sympathetic_trunk] xref: AAO:0010791 xref: BAMS:S xref: BTO:0001834 xref: CALOHA:TS-2049 xref: EV:0100374 xref: FMA:6258 xref: SCTID:181099004 xref: Wikipedia:Sympathetic_trunk xref: XAO:0000211 is_a: UBERON:0000062 ! organ is_a: UBERON:0015212 ! lateral structure relationship: BSPO:0000126 UBERON:0000013 {source="FMA-abduced-lr"} ! sympathetic nervous system property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/2/2d/Gray847.png" xsd:anyURI [Term] id: UBERON:0000409 name: serous gland def: "A gland in which the principal secretory cells are serous secreting cells." [http://orcid.org/0000-0002-6601-2165, http://www.siumed.edu/~dking2/intro/glands.htm] subset: organ_slim subset: pheno_slim xref: BTO:0001837 xref: EMAPA:37950 {source="MA:th"} xref: FMA:62889 xref: Wikipedia:Serous_gland is_a: UBERON:0002365 ! exocrine gland intersection_of: UBERON:0002365 ! exocrine gland intersection_of: BFO:0000051 CL:0000313 ! has part serous secreting cell relationship: BFO:0000051 UBERON:0013232 ! has part serous acinus relationship: RO:0003000 UBERON:0007794 ! produces secretion of serous gland property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/c/c0/Gray1021.png" xsd:anyURI property_value: skos:prefLabel "serous gland" xsd:string [Term] id: UBERON:0000410 name: bronchial mucosa def: "A mucosa that is part of a bronchus [Automatically generated definition]." [OBOL:automatic] synonym: "bronchi mucosa" EXACT [OBOL:automatic] synonym: "bronchi mucosa of organ" EXACT [OBOL:automatic] synonym: "bronchi mucous membrane" EXACT [OBOL:automatic] synonym: "bronchi organ mucosa" EXACT [OBOL:automatic] synonym: "bronchial trunk mucosa" EXACT [OBOL:automatic] synonym: "bronchial trunk mucosa of organ" EXACT [OBOL:automatic] synonym: "bronchial trunk mucous membrane" EXACT [OBOL:automatic] synonym: "bronchial trunk organ mucosa" EXACT [OBOL:automatic] synonym: "bronchus mucosa" EXACT [OBOL:automatic] synonym: "bronchus mucosa of organ" EXACT [OBOL:automatic] synonym: "bronchus mucous membrane" EXACT [OBOL:automatic] synonym: "bronchus organ mucosa" EXACT [OBOL:automatic] synonym: "mucosa of bronchi" EXACT [OBOL:automatic] synonym: "mucosa of bronchial trunk" EXACT [OBOL:automatic] synonym: "mucosa of bronchus" EXACT [OBOL:automatic] synonym: "mucosa of organ of bronchi" EXACT [OBOL:automatic] synonym: "mucosa of organ of bronchial trunk" EXACT [OBOL:automatic] synonym: "mucosa of organ of bronchus" EXACT [OBOL:automatic] synonym: "mucous membrane of bronchi" EXACT [OBOL:automatic] synonym: "mucous membrane of bronchial trunk" EXACT [OBOL:automatic] synonym: "mucous membrane of bronchus" EXACT [FMA:62652, OBOL:automatic] synonym: "organ mucosa of bronchi" EXACT [OBOL:automatic] synonym: "organ mucosa of bronchial trunk" EXACT [OBOL:automatic] synonym: "organ mucosa of bronchus" EXACT [OBOL:automatic] synonym: "tunica mucosa bronchi" EXACT OMO:0003011 [FMA:62652, FMA:TA] xref: BTO:0001846 xref: FMA:62652 xref: SCTID:30802009 is_a: UBERON:0004785 ! respiratory system mucosa intersection_of: UBERON:0000344 ! mucosa intersection_of: BFO:0000050 UBERON:0002185 ! part of bronchus relationship: BFO:0000050 UBERON:0002185 ! part of bronchus property_value: skos:prefLabel "bronchial mucosa" xsd:string [Term] id: UBERON:0000412 name: dermal papilla def: "A mesodermal signaling center of the hair follicle consisting of closely packed specialized mesenchymal fibroblasts. Framed by the enlarged bulb matrix in anagen." [DOI:10.1016/j.cub.2008.12.005] subset: human_reference_atlas subset: pheno_slim synonym: "dermal papilla cell" RELATED [BTO:0001858] synonym: "dermal papillae" EXACT OMO:0003004 [] synonym: "follicular papilla" EXACT [FMA:70737] synonym: "hair follicle dermal papilla" RELATED [MP:0010687] synonym: "hair papilla" RELATED [] synonym: "papilla corii" RELATED [BTO:0001858] synonym: "papilla dermatis" RELATED [BTO:0001858] synonym: "papilla dermis" RELATED [BTO:0001858] synonym: "papilla of corium" RELATED [BTO:0001858] synonym: "papillae dermis" RELATED OMO:0003011 [Wikipedia:Dermal_papillae] synonym: "skin papilla" RELATED [BTO:0001858] xref: BTO:0001858 xref: CALOHA:TS-0431 xref: EMAPA:36484 xref: FMA:70737 xref: NCIT:C32710 xref: NCIT:C83189 xref: SCTID:320101005 xref: UMLS:C0221931 {source="ncithesaurus:Dermal_Papilla"} xref: Wikipedia:Dermal_papillae is_a: BFO:0000002 is_a: UBERON:0000479 ! tissue relationship: BFO:0000050 UBERON:0001992 ! part of papillary layer of dermis relationship: RO:0002473 CL:0000057 ! composed primarily of fibroblast property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/3/34/Skin.jpg" xsd:anyURI property_value: IAO:0000116 "consider adding grouping class for TAO:0001995 ! papilla" xsd:string property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0000414 name: mucous gland def: "A gland in which the principal secretory cells are mucus secreting cells." [http://orcid.org/0000-0002-6601-2165, http://www.siumed.edu/~dking2/intro/glands.htm] subset: organ_slim synonym: "glandula mucosa" EXACT OMO:0003011 [Wikipedia:Mucous_gland] synonym: "muciparous gland" RELATED [BTO:0001979] synonym: "mucous secreting gland" RELATED [] synonym: "mucus gland" RELATED [] synonym: "mucus-secreting gland" RELATED [] xref: AAO:0010601 xref: BTO:0001979 xref: EMAPA:37913 {source="MA:th"} xref: FMA:62888 xref: Wikipedia:Mucous_gland is_a: UBERON:0002365 ! exocrine gland intersection_of: UBERON:0002365 ! exocrine gland intersection_of: BFO:0000051 CL:0000319 ! has part mucus secreting cell relationship: BFO:0000051 CL:0000319 ! has part mucus secreting cell relationship: RO:0002215 GO:0070254 ! capable of mucus secretion relationship: RO:0003000 UBERON:0000912 ! produces mucus property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/c/c0/Gray1021.png" xsd:anyURI property_value: skos:prefLabel "mucous gland" xsd:string [Term] id: UBERON:0000415 name: artery wall def: "An anatomical wall that is part of an artery [Automatically generated definition]." [OBOL:automatic] synonym: "arterial wall" EXACT [FMA:14155] synonym: "wall of artery" EXACT [FMA:14155] xref: BTO:0002009 xref: FMA:14155 xref: galen:ArterialWall is_a: UBERON:0035965 ! wall of blood vessel intersection_of: UBERON:0000060 ! anatomical wall intersection_of: BFO:0000050 UBERON:0001637 ! part of artery relationship: BFO:0000050 UBERON:0001637 ! part of artery property_value: skos:prefLabel "artery wall" xsd:string [Term] id: UBERON:0000420 name: myoepithelium def: "An epithelium consisting of myopethelial cells, which are contractile cells resembling smooth muscle cells that are present in glands, notably the mammary gland, and aid in secretion. This cell has long weaving dendritic processes containing myofilament[CL]." [CL:0000185, Wikipedia:Myoepithelial_cell] synonym: "myo-epithelium" EXACT [FMA:67805] synonym: "myoepitheliocytus" RELATED OMO:0003011 [Wikipedia:Myoepithelial_cell] xref: BTO:0002308 xref: FMA:67805 xref: Wikipedia:Myoepithelial_cell is_a: UBERON:0000488 ! atypical epithelium intersection_of: UBERON:0000488 ! atypical epithelium intersection_of: RO:0002473 CL:0000185 ! composed primarily of myoepithelial cell relationship: BFO:0000051 GO:0036379 ! has part myofilament relationship: RO:0002473 CL:0000185 ! composed primarily of myoepithelial cell [Term] id: UBERON:0000423 name: eccrine sweat gland def: "A merocrine, unbranched, unbranched, coiled, tubular gland sweat gland. In humans, distributed over almost all of the body surface, and promote cooling by evaporation of their secretion." [http://orcid.org/0000-0002-6601-2165, Wikipedia:Eccrine_sweat_gland] subset: human_reference_atlas subset: organ_slim subset: pheno_slim synonym: "eccrine gland" RELATED [FMA:59154] synonym: "glandula sudorifera eccrina" EXACT OMO:0003011 [Wikipedia:Eccrine_sweat_gland] synonym: "glandula sudorifera merocrina" EXACT OMO:0003011 [Wikipedia:Eccrine_sweat_gland] synonym: "merocrine sweat gland" RELATED [] xref: BTO:0002323 xref: FMA:59154 xref: GAID:945 xref: MA:0003039 xref: MESH:D004439 xref: NCIT:C32490 xref: SCTID:361699008 xref: UMLS:C0013492 {source="ncithesaurus:Eccrine_Sweat_Gland"} xref: Wikipedia:Eccrine_sweat_gland is_a: UBERON:0001820 ! sweat gland is_a: UBERON:0010243 {source="MGI:anna"} ! merocrine gland property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0000424 name: gastric pit def: "Gastric pits are indentations in the stomach which denote entrances to the gastric glands. They are deeper in the pylorus than they are in the other parts of the stomach. The human stomach has several million of these pits." [Wikipedia:Gastric_pits] synonym: "foveola gastrica" RELATED [BTO:0002364] synonym: "foveolae gastricae" EXACT OMO:0003004 [FMA:76583, FMA:TA] synonym: "foveolae gastricae" RELATED OMO:0003011 [Wikipedia:Gastric_pits] synonym: "gastric foveola" EXACT [FMA:62947] xref: BTO:0002364 xref: FMA:62947 xref: NCIT:C32659 xref: SCTID:268426007 xref: UMLS:C0227203 {source="ncithesaurus:Gastric_Pit"} xref: Wikipedia:Gastric_pits is_a: UBERON:0002553 ! anatomical cavity relationship: BFO:0000050 UBERON:0001199 {source="BTO"} ! part of mucosa of stomach property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/7/73/Illu_stomach_layers.jpg" xsd:anyURI [Term] id: UBERON:0000428 name: prostate epithelium def: "The prostate epithelium." [MP:0001168] subset: human_reference_atlas subset: pheno_slim synonym: "epithelial tissue of prostate" EXACT [OBOL:automatic] synonym: "epithelial tissue of prostate gland" EXACT [OBOL:automatic] synonym: "epithelium of prostate" EXACT [OBOL:automatic] synonym: "epithelium of prostate gland" EXACT [OBOL:automatic] synonym: "epithelium of prostatic gland" EXACT [FMA:79643] synonym: "prostate epithelial tissue" EXACT [OBOL:automatic] synonym: "prostate gland epithelial tissue" EXACT [OBOL:automatic] synonym: "prostate gland epithelium" EXACT [] synonym: "prostatic epithelium" EXACT [FMA:66812] synonym: "prostatic gland epithelium" EXACT [] xref: BTO:0002397 xref: CALOHA:TS-2065 xref: EMAPA:35711 xref: FMA:66812 xref: FMA:79643 xref: MA:0001737 xref: NCIT:C13103 xref: UMLS:C1179826 {source="ncithesaurus:Prostatic_Epithelium"} is_a: UBERON:0000485 ! simple columnar epithelium is_a: UBERON:0005156 ! reproductive structure is_a: UBERON:0005911 ! endo-epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: BFO:0000050 UBERON:0002367 ! part of prostate gland relationship: BFO:0000050 UBERON:0002367 ! part of prostate gland property_value: IAO:0000116 "TODO - check 2 FMA IDs" xsd:string property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0000429 name: enteric plexus def: "A plexus of autonomic nerve fibers within the wall of the digestive tube, and made up of the submucosal, myenteric, and subserosal plexuses; it contains visceral afferent fibers, sympathetic postganglionic fibers, parasympathetic preganglionic and postganglionic fibers, and parasympathetic postganglionic cell bodies." [BTO:0002437] subset: human_reference_atlas synonym: "enteric nerve plexus" EXACT [FMA:77597] synonym: "intrinsic nerve plexus" EXACT [MA:0001147] synonym: "plexus entericus" EXACT [BTO:0002437] synonym: "plexus nervosus entericus" EXACT OMO:0003011 [FMA:77597, FMA:TA] synonym: "sympathetic enteric nerve plexus" EXACT [FMA:77597] xref: BTO:0002437 xref: EMAPA:35446 xref: FMA:77597 xref: MA:0001147 is_a: UBERON:0001816 ! autonomic nerve plexus intersection_of: UBERON:0001810 ! nerve plexus intersection_of: BFO:0000050 UBERON:0002005 ! part of enteric nervous system relationship: BFO:0000050 UBERON:0002005 ! part of enteric nervous system property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0000437 name: arachnoid barrier layer def: "The arachnoid barrier layer is a part of the arachnoid meningeal layer. It is formed by tight junctions between the endothelial cells of cerebral capillaries in the arachnoid mater." [BTO:0002498] xref: BTO:0002498 xref: FMA:231559 is_a: UBERON:0004923 {source="FMA"} ! organ component layer relationship: BFO:0000050 UBERON:0000201 {source="cjm"} ! part of endothelial blood brain barrier relationship: BFO:0000050 UBERON:0002362 {source="FMA"} ! part of arachnoid mater relationship: RO:0002473 GO:0005923 ! composed primarily of bicellular tight junction [Term] id: UBERON:0000439 name: arachnoid trabecula def: "The arachnoid trabeculae are delicate strands of connective tissue that loosely connect the two innermost layers of the meninges -- the arachnoid mater and the pia mater. They are found within the subarachnoid space where cerebrospinal fluid is also found. Embryologically, the trabeculae are the remnants of the common precursor that forms both the arachnoid and pial layers of the meninges." [Wikipedia:Arachnoid_trabeculae] synonym: "arachnoid trabeculae" RELATED OMO:0003004 [] synonym: "trabecula arachnoideum" RELATED OMO:0003011 [] xref: BTO:0002500 xref: FMA:83979 xref: Wikipedia:Arachnoid_trabeculae is_a: UBERON:0000440 ! trabecula intersection_of: UBERON:0000440 ! trabecula intersection_of: BFO:0000050 UBERON:0002362 ! part of arachnoid mater relationship: BFO:0000050 UBERON:0002362 ! part of arachnoid mater relationship: BFO:0000051 GO:0005581 ! has part collagen trimer property_value: skos:prefLabel "arachnoid trabecula" xsd:string [Term] id: UBERON:0000440 name: trabecula def: "A small, often microscopic, tissue element in the form of a small beam, strut or rod, generally having a mechanical function, and usually but not necessarily composed of dense collagenous tissue. On histological section, a trabecula can look like a septum, but in three dimensions they are topologically distinct, with trabeculae being roughly rod or pillar-shaped and septa being sheet-like. Trabeculae are usually composed of dense fibrous tissue, i.e. mainly of collagen, and in most cases provide mechanical strengthening or stiffening to a soft solid organ, such as the spleen. They can be composed of other materials, such as bone or muscle[WP]." [GO:0060343, Wikipedia:Trabecula] subset: grouping_class subset: pheno_slim synonym: "trabeculae" EXACT OMO:0003004 [] xref: BTO:0002501 xref: FMA:85273 xref: Wikipedia:Trabecula is_a: UBERON:0000064 ! organ part relationship: BFO:0000051 UBERON:0002384 ! has part connective tissue relationship: RO:0000086 PATO:0001873 ! has quality cylindrical property_value: skos:prefLabel "trabecula" xsd:string [Term] id: UBERON:0000442 name: right testicular vein def: "A vein that drains the left pampiniform plexus and empties into the left renal vein." [Dorlands_Medical_Dictionary:MerckSource] subset: human_reference_atlas synonym: "right spermatic vein" EXACT [MA:0002220] synonym: "vena testicularis (adrenalis) dextra" EXACT [FMA:14341] synonym: "vena testicularis dextra" RELATED [BTO:0002679] synonym: "vena testicularis sinistra" RELATED [BTO:0002680] xref: BTO:0002679 xref: EMAPA:37383 {source="MA:th"} xref: FMA:14341 xref: MA:0002220 xref: NCIT:C52697 xref: SCTID:53500001 is_a: UBERON:0001144 ! testicular vein intersection_of: UBERON:0001144 ! testicular vein intersection_of: RO:0020102 UBERON:0004534 ! vessel drains blood from right testis relationship: BSPO:0000120 UBERON:0000468 ! multicellular organism relationship: RO:0002170 UBERON:0001142 ! connected to left renal vein relationship: RO:0020102 UBERON:0004534 ! vessel drains blood from right testis property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0000443 name: left testicular vein def: "A vein that drains the right pampiniform plexus and empties into the inferior vena cava." [Dorlands_Medical_Dictionary:MerckSource] subset: human_reference_atlas synonym: "left spermatic vein" EXACT [MA:0002219] synonym: "vena testicularis dextra" RELATED [BTO:0002679] synonym: "vena testicularis sinistra" RELATED [BTO:0002680] xref: BTO:0002680 xref: EMAPA:37167 {source="MA:th"} xref: FMA:14345 xref: MA:0002219 xref: NCIT:C52696 xref: SCTID:90988008 is_a: UBERON:0001144 ! testicular vein intersection_of: UBERON:0001144 ! testicular vein intersection_of: RO:0020102 UBERON:0004533 ! vessel drains blood from left testis relationship: BSPO:0000120 UBERON:0000468 ! multicellular organism relationship: RO:0002170 UBERON:0001142 ! connected to left renal vein relationship: RO:0020102 UBERON:0004533 ! vessel drains blood from left testis property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0000444 name: lymphoid follicle synonym: "folliculus lymphaticus" RELATED [BTO:0002684] synonym: "lymphatic follicle" RELATED [BTO:0002684] synonym: "lymphatic nodule" RELATED [BTO:0002684] synonym: "lymphoid nodule" RELATED [FMA:55222] synonym: "nodular lymphoid tissue" EXACT [FMA:55222] synonym: "nodulus lymphaticus" RELATED [BTO:0002684] synonym: "nodulus lymphoideus" RELATED [BTO:0002684] xref: BTO:0002684 xref: FMA:55222 xref: NCIT:C33040 xref: SCTID:64626006 xref: UMLS:C0229654 {source="ncithesaurus:Lymphoid_Follicle"} is_a: UBERON:0001744 {source="FMA"} ! lymphoid tissue property_value: IAO:0000116 "introducing part_of to 'cortex of lymph node' as in issue 7 introduces equivalencies; the part_of has instead been added to 'lymph node follicle'" xsd:string property_value: seeAlso "https://github.com/obophenotype/uberon/issues/6" xsd:anyURI property_value: seeAlso "https://github.com/obophenotype/uberon/issues/7" xsd:anyURI property_value: terms:contributor https://orcid.org/0000-0002-6601-2165 property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 [Term] id: UBERON:0000446 name: septum of telencephalon def: "Gray matter structure located on the midline of the forebrain consisting of the septum pellucidum (in some species) and the septal nuclei (Heimer, 1996)." [BIRNLEX:963] subset: pheno_slim synonym: "area septalis" EXACT OMO:0003011 [FMA:61842, FMA:TA] synonym: "massa praecommissuralis" RELATED OMO:0003011 [NeuroNames:255] synonym: "Se" BROAD OMO:0003000 [PMID:23375746] synonym: "septal area" EXACT [FMA:61842] synonym: "septal region" RELATED [BAMS:SEP] synonym: "septum" BROAD [BIRNLEX:963] synonym: "septum (NN)" EXACT [FMA:61842] synonym: "septum pellucidum (BNA,PNA)" RELATED OMO:0003011 [NeuroNames:255] synonym: "septum telencephali" RELATED OMO:0003011 [NeuroNames:255] synonym: "telencephalon septum" EXACT [FMA:61842] xref: BAMS:SA xref: BAMS:SEP xref: BAMS:Sep xref: BAMS:Spt xref: BIRNLEX:963 xref: BM:Tel-Spt xref: BTO:0002705 xref: EMAPA:32837 xref: FMA:61842 xref: MA:0000924 xref: neuronames:255 {source="BIRNLEX:963"} xref: UMLS:C0752060 {source="BIRNLEX:963"} is_a: UBERON:0005401 ! cerebral hemisphere gray matter property_value: skos:prefLabel "septum of telencephalon" xsd:string [Term] id: UBERON:0000454 name: cerebral subcortex def: "The layer located below the cerebral cortex that includes the forebrain, midbrain and hindbrain." [ncithesaurus:Cerebral_Subcortex] subset: pheno_slim synonym: "cerebral medulla" EXACT [FMA:242188] synonym: "subcortex" RELATED [BTO:0002858] xref: BTO:0002858 xref: FMA:242188 xref: NCIT:C98712 xref: UMLS:C0815008 {source="ncithesaurus:Cerebral_Subcortex"} is_a: UBERON:0000064 ! organ part relationship: BFO:0000050 UBERON:0000955 ! part of brain property_value: skos:prefLabel "cerebral subcortex" xsd:string [Term] id: UBERON:0000456 name: secretion of exocrine gland def: "A portion of organism substance that is produced by exocrine glands." [http://orcid.org/0000-0002-6601-2165] synonym: "bodily secretion" EXACT [MESH:D012634] synonym: "exocrine gland fluid" RELATED [] synonym: "exocrine gland fluid or secretion" RELATED [] synonym: "exocrine gland fluid/secretion" EXACT [MA:0002504] synonym: "exocrine gland secretion" RELATED [] synonym: "external secretion" RELATED [BTO:0002977] synonym: "secreted substance" EXACT [] synonym: "secretion" BROAD [FMA:9675] xref: AEO:0001005 xref: BTO:0002977 xref: BTO:0002979 xref: EMAPA:36535 xref: FMA:9675 xref: galen:Secretion xref: MA:0002504 xref: MESH:D012634 xref: NCIT:C34062 xref: UMLS:C1516992 {source="ncithesaurus:Exocrine_Gland_Fluid_or_Secretion"} is_a: UBERON:0000463 ! organism substance intersection_of: UBERON:0000463 ! organism substance intersection_of: RO:0003001 UBERON:0002365 ! produced by exocrine gland relationship: RO:0003001 UBERON:0002365 ! produced by exocrine gland property_value: skos:prefLabel "secretion of exocrine gland" xsd:string [Term] id: UBERON:0000457 name: cavernous artery def: "Any of several small branches of the internal carotid artery that supply the trigeminal ganglion and the walls of the cavernous and petrosal sinuses." [BTO:0002996] synonym: "cavernous branch of cavernous part of internal carotid artery" EXACT [FMA:70527] synonym: "ramus sinus cavernosi (pars cavernosa) (arteria carotis interna)" EXACT OMO:0003011 [FMA:70527, FMA:TA] xref: BTO:0002996 xref: FMA:70527 is_a: UBERON:0001637 ! artery intersection_of: UBERON:0001637 ! artery intersection_of: RO:0002252 UBERON:0001532 ! connecting branch of internal carotid artery intersection_of: RO:0020101 UBERON:0001675 ! vessel supplies blood to trigeminal ganglion relationship: RO:0002252 UBERON:0001532 ! connecting branch of internal carotid artery relationship: RO:0020101 UBERON:0001675 ! vessel supplies blood to trigeminal ganglion property_value: skos:prefLabel "cavernous artery" xsd:string [Term] id: UBERON:0000458 name: endocervix def: "The region of the opening of the uterine cervix into the uterine cavity." [BTO:0003002] subset: human_reference_atlas xref: BTO:0003002 xref: FMA:86485 xref: NCIT:C12309 xref: SCTID:264460007 xref: UMLS:C0227837 {source="ncithesaurus:Endocervix"} is_a: UBERON:0000064 ! organ part is_a: UBERON:0005156 ! reproductive structure intersection_of: UBERON:0000064 ! organ part intersection_of: BSPO:0001106 UBERON:0000002 ! uterine cervix relationship: BFO:0000051 UBERON:0000485 ! has part simple columnar epithelium relationship: BSPO:0001106 UBERON:0000002 ! uterine cervix property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0000459 name: uterine wall def: "An anatomical wall that is part of a uterus [Automatically generated definition]." [OBOL:automatic] synonym: "anatomical wall of uterus" EXACT [OBOL:automatic] synonym: "uterus anatomical wall" EXACT [OBOL:automatic] synonym: "uterus wall" EXACT [OBOL:automatic] synonym: "wall of uterus" EXACT [OBOL:automatic] xref: BTO:0003083 xref: FMA:17560 xref: SCTID:245485002 is_a: UBERON:0000060 ! anatomical wall is_a: UBERON:0005156 ! reproductive structure intersection_of: UBERON:0000060 ! anatomical wall intersection_of: BFO:0000050 UBERON:0000995 ! part of uterus relationship: BFO:0000050 UBERON:0000995 ! part of uterus [Term] id: UBERON:0000463 name: organism substance def: "Material anatomical entity in a gaseous, liquid, semisolid or solid state; produced by anatomical structures or derived from inhaled and ingested substances that have been modified by anatomical structures as they pass through the body." [http://orcid.org/0000-0001-9114-8737] subset: common_anatomy subset: pheno_slim subset: upper_level synonym: "body fluid or substance" EXACT [MA:0002450] synonym: "body substance" EXACT [FMA:9669] synonym: "organism substance" EXACT [CARO:0000004] synonym: "portion of body substance" EXACT [FMA:9669] synonym: "portion of organism substance" EXACT [ZFA:0001487] xref: AAO:0010839 xref: AEO:0000004 xref: BILA:0000004 xref: CALOHA:TS-2101 xref: CARO:0000004 xref: EHDAA2:0003004 xref: EMAPA:35178 xref: FBbt:00007019 {sssom:mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"} xref: FMA:9669 xref: galen:BodySubstance xref: HAO:0000004 xref: MA:0002450 xref: NCIT:C13236 xref: SPD:0000008 xref: TAO:0001487 xref: TGMA:0001824 xref: VHOG:0001726 xref: XAO:0004001 xref: ZFA:0001487 is_a: BFO:0000004 is_a: UBERON:0000465 ! material anatomical entity relationship: BFO:0000050 UBERON:0000468 ! part of multicellular organism relationship: RO:0000086 PATO:0002198 ! has quality quality of a substance property_value: RO:0002175 NCBITaxon:33090 property_value: RO:0002175 NCBITaxon:33208 property_value: RO:0002175 NCBITaxon:4751 property_value: skos:prefLabel "organism substance" xsd:string [Term] id: UBERON:0000464 name: anatomical space def: "Non-material anatomical entity of three dimensions, that is generated by morphogenetic or other physiologic processes; is surrounded by one or more anatomical structures; contains one or more organism substances or anatomical structures." [http://orcid.org/0000-0001-9114-8737] subset: common_anatomy subset: upper_level synonym: "anatomical spaces" RELATED OMO:0003004 [ZFA:0001643] synonym: "lumen" BROAD [] synonym: "lumen space" EXACT [] synonym: "space" BROAD [] xref: AAO:0010110 xref: AEO:0000005 xref: BILA:0000005 xref: CARO:0000005 xref: EHDAA2:0003005 xref: FBbt:00007017 {sssom:mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"} xref: FMA:5897 xref: HAO:0000005 xref: NCIT:C94478 xref: TAO:0001668 xref: TGMA:0001825 xref: UMLS:C0524461 {source="ncithesaurus:Lumen_Space"} xref: VHOG:0001728 xref: XAO:0003190 xref: ZFA:0001643 is_a: BFO:0000004 is_a: UBERON:0000466 ! immaterial anatomical entity relationship: RO:0002219 UBERON:0000061 ! surrounded by anatomical structure property_value: RO:0002175 NCBITaxon:33090 property_value: RO:0002175 NCBITaxon:33208 property_value: RO:0002175 NCBITaxon:4751 property_value: skos:prefLabel "anatomical space" xsd:string [Term] id: UBERON:0000465 name: material anatomical entity def: "Anatomical entity that has mass." [http://orcid.org/0000-0001-9114-8737] subset: common_anatomy subset: upper_level xref: AAO:0010264 xref: AEO:0000006 xref: BILA:0000006 xref: CARO:0000006 xref: EHDAA2:0003006 xref: FBbt:00007016 {sssom:mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"} xref: FMA:67165 xref: HAO:0000006 xref: TAO:0001836 xref: TGMA:0001826 xref: VHOG:0001721 is_a: BFO:0000040 is_a: UBERON:0001062 ! anatomical entity disjoint_from: UBERON:0000466 ! immaterial anatomical entity property_value: RO:0002175 NCBITaxon:33090 property_value: RO:0002175 NCBITaxon:33208 property_value: RO:0002175 NCBITaxon:4751 property_value: skos:prefLabel "material anatomical entity" xsd:string [Term] id: UBERON:0000466 name: immaterial anatomical entity def: "Anatomical entity that has no mass." [http://orcid.org/0000-0001-9114-8737] subset: common_anatomy subset: upper_level synonym: "immaterial physical anatomical entity" EXACT [FMA:67112] xref: AAO:0010265 xref: AEO:0000007 xref: BILA:0000007 xref: CARO:0000007 xref: EHDAA2:0003007 xref: FBbt:00007015 {sssom:mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"} xref: FMA:67112 xref: HAO:0000007 xref: TAO:0001835 xref: TGMA:0001827 xref: VHOG:0001727 is_a: BFO:0000141 is_a: UBERON:0001062 ! anatomical entity property_value: RO:0002175 NCBITaxon:33090 property_value: RO:0002175 NCBITaxon:33208 property_value: RO:0002175 NCBITaxon:4751 property_value: skos:prefLabel "immaterial anatomical entity" xsd:string [Term] id: UBERON:0000467 name: anatomical system def: "Multicellular, connected anatomical structure that has multiple organs as parts and whose parts work together to achieve some shared function." [CARO:0000011] subset: common_anatomy subset: human_reference_atlas subset: pheno_slim subset: uberon_slim subset: upper_level synonym: "anatomical systems" RELATED OMO:0003004 [ZFA:0001439] synonym: "body system" EXACT [BIRNLEX:14] synonym: "connected anatomical system" EXACT [CARO:0000011] synonym: "organ system" EXACT [] synonym: "system" BROAD [GO:0048731] xref: AAO:0000007 xref: AEO:0000011 xref: BILA:0000011 xref: BIRNLEX:14 xref: BSA:0000049 xref: CALOHA:TS-2088 xref: CARO:0000011 xref: EHDAA2:0003011 xref: EHDAA:392 xref: EMAPA:16103 xref: EV:0100000 xref: FBbt:00004856 {sssom:mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"} xref: FMA:7149 xref: galen:AnatomicalSystem xref: HAO:0000011 xref: MA:0000003 xref: NCIT:C12919 xref: SCTID:278195005 xref: TAO:0001439 xref: TGMA:0001831 xref: UMLS:C0460002 {source="ncithesaurus:Organ_System"} xref: VHOG:0001725 xref: WBbt:0005746 xref: WBbt:0005763 xref: Wikipedia:Organ_system xref: XAO:0003002 xref: ZFA:0001439 is_a: UBERON:0000061 ! anatomical structure relationship: BFO:0000050 UBERON:0000468 ! part of multicellular organism relationship: BFO:0000051 UBERON:0000062 ! has part organ property_value: RO:0002175 NCBITaxon:33090 property_value: RO:0002175 NCBITaxon:33208 property_value: RO:0002175 NCBITaxon:4751 property_value: RO:0002175 NCBITaxon:9606 property_value: seeAlso EHDAA2:0001330 property_value: skos:prefLabel "anatomical system" xsd:string [Term] id: UBERON:0000468 name: multicellular organism def: "Anatomical structure that is an individual member of a species and consists of more than one cell." [CARO:0000012, http://orcid.org/0000-0001-9114-8737, Wikipedia:Multi-cellular_organism] subset: common_anatomy subset: efo_slim subset: pheno_slim subset: uberon_slim subset: upper_level synonym: "body" RELATED [AEO:0000103, BIRNLEX:18, FMA:256135, NCIT:C13041] synonym: "Koerper" RELATED [BTO:0001489] synonym: "multi-cellular organism" EXACT [CARO:0000012] synonym: "organism" BROAD [FBbt:00000001, VHOG:0000671, WBbt:0007833] synonym: "whole body" RELATED [BTO:0001489] synonym: "whole organism" RELATED [FBbt:00000001] xref: AAO:0010026 xref: AEO:0000191 xref: BILA:0000012 xref: BIRNLEX:18 xref: BSA:0000038 xref: BTO:0000042 xref: CARO:0000012 xref: EFO:0002906 xref: EHDAA2:0003103 xref: EHDAA2:0003191 xref: EHDAA:1 xref: EMAPA:25765 xref: EV:0100016 xref: FBbt:00000001 {sssom:mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"} xref: FMA:256135 xref: galen:Organism xref: HAO:0000012 xref: NCIT:C13041 xref: ncithesaurus:Whole_Organism xref: SCTID:243928005 xref: TADS:0000001 xref: TAO:0001094 xref: TGMA:0001832 xref: VHOG:0000671 xref: WBbt:0007833 xref: Wikipedia:Multi-cellular_organism xref: XAO:0003004 xref: ZFA:0001094 is_a: UBERON:0010000 ! multicellular anatomical structure property_value: IAO:0000116 "TODO - split body and mc organism? body continues after death stage" xsd:string property_value: RO:0002175 NCBITaxon:33090 property_value: RO:0002175 NCBITaxon:33208 property_value: RO:0002175 NCBITaxon:4751 property_value: skos:prefLabel "multicellular organism" xsd:string [Term] id: UBERON:0000471 name: compound organ component def: "Multi-tissue structure that is part of a compound organ." [CARO:0000019, http://orcid.org/0000-0001-9114-8737] subset: upper_level synonym: "compound organ components" RELATED OMO:0003004 [ZFA:0001489] xref: AAO:0010017 xref: AEO:0000019 xref: BILA:0000019 xref: CARO:0000019 xref: EHDAA2:0003019 xref: HAO:0000019 xref: TAO:0001489 xref: TGMA:0001835 xref: XAO:0003039 xref: ZFA:0001489 is_a: UBERON:0000481 ! multi-tissue structure relationship: BFO:0000050 UBERON:0003103 ! part of compound organ property_value: skos:prefLabel "compound organ component" xsd:string [Term] id: UBERON:0000473 name: testis def: "A gonad of a male animal. A gonad produces and releases sperm." [http://orcid.org/0000-0002-6601-2165] subset: efo_slim subset: organ_slim subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "gonad of male genitalia" EXACT [OBOL:automatic] synonym: "gonad of male reproductive system" EXACT [OBOL:automatic] synonym: "male gonad" EXACT [OBOL:automatic] synonym: "orchis" RELATED [BTO:0001363] synonym: "testes" RELATED OMO:0003004 [] synonym: "testicle" EXACT [FMA:7210] synonym: "testiculus" RELATED OMO:0003011 [BTO:0001363] xref: AAO:0000606 xref: BILA:0000124 xref: BSA:0000085 xref: BTO:0001363 xref: CALOHA:TS-1030 xref: EFO:0000984 xref: EHDAA2:0002007 xref: EHDAA:8146 xref: EMAPA:17972 xref: EV:0100102 xref: FBbt:00004928 {sssom:mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"} xref: FMA:7210 xref: GAID:396 xref: galen:Testis xref: HAO:0001007 xref: MA:0000411 xref: MAT:0000132 xref: MESH:D013737 xref: MIAA:0000132 xref: NCIT:C12412 xref: SCTID:181431007 xref: TAO:0000598 xref: UMLS:C0039597 {source="ncithesaurus:Testis"} xref: VHOG:0000252 xref: WBbt:0006794 xref: Wikipedia:Testis xref: XAO:0000157 xref: ZFA:0000598 is_a: UBERON:0000991 ! gonad is_a: UBERON:0003135 ! male reproductive organ intersection_of: UBERON:0000991 ! gonad intersection_of: BFO:0000050 UBERON:0000079 ! part of male reproductive system disjoint_from: UBERON:0000992 ! ovary disjoint_from: UBERON:0009117 ! indifferent gonad relationship: RO:0002202 UBERON:0009117 ! develops from indifferent gonad property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/c/c3/Gray1144.png" xsd:anyURI [Term] id: UBERON:0000474 name: female reproductive system def: "The organs and associated structures associated with bearing offspring in a female animal." [http://orcid.org/0000-0002-6601-2165, MP:0001119, Wikipedia:Female_genitalia] subset: efo_slim subset: human_reference_atlas subset: pheno_slim subset: uberon_slim synonym: "female genital system" RELATED [] synonym: "female genital tract" RELATED [] synonym: "female genitalia" RELATED [] synonym: "female genitals" RELATED OMO:0003004 [XAO:0000156] synonym: "female organism genitalia" EXACT [OBOL:automatic] synonym: "female organism reproductive system" EXACT [OBOL:automatic] synonym: "female reproductive tract" RELATED [MA:0000381] synonym: "genitalia of female organism" EXACT [OBOL:automatic] synonym: "gynaecological tissue" RELATED [BTO:0000083] synonym: "reproductive system of female organism" EXACT [OBOL:automatic] synonym: "systema genitale femininum" RELATED [BTO:0000083] xref: BTO:0000083 xref: CALOHA:TS-1303 xref: EFO:0000969 xref: EHDAA2:0000506 xref: EHDAA:8116 xref: EMAPA:17959 xref: EV:0100110 xref: FBbt:00004864 {sssom:mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"} xref: FMA:45663 xref: GAID:364 xref: HAO:0000324 xref: MA:0000381 xref: MESH:D005836 xref: MIAA:0000028 xref: NCIT:C12402 xref: SCTID:361386004 xref: TGMA:0000635 xref: UMLS:C0700038 {source="ncithesaurus:Female_Reproductive_System"} xref: VHOG:0000726 xref: Wikipedia:Female_genitalia xref: WikipediaCategory:Female_reproductive_system xref: XAO:0000156 is_a: UBERON:0000990 ! reproductive system intersection_of: UBERON:0000990 ! reproductive system intersection_of: BFO:0000050 UBERON:0003100 ! part of female organism relationship: BFO:0000050 UBERON:0003100 ! part of female organism property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/6/68/Scheme_female_reproductive_system-en.svg" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "female reproductive system" xsd:string [Term] id: UBERON:0000475 name: organism subdivision def: "Anatomical structure which is a subdivision of a whole organism, consisting of components of multiple anatomical systems, largely surrounded by a contiguous region of integument." [CARO:0000032, CARO:DOS, http://orcid.org/0000-0001-9114-8737] subset: common_anatomy subset: efo_slim subset: pheno_slim subset: uberon_slim subset: upper_level synonym: "anatomic region" EXACT [MA:0002433] synonym: "body part" RELATED [] synonym: "body region" RELATED [FMA:7153] synonym: "cardinal body part" RELATED [FMA:7153] xref: AAO:0010053 xref: AEO:0000032 xref: BILA:0000032 xref: BIRNLEX:7 xref: CALOHA:TS-2084 xref: CARO:0000032 xref: EFO:0000808 xref: EHDAA2:0003032 xref: EMAPA:36031 xref: FBbt:00007009 {sssom:mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"} xref: FMA:7153 xref: galen:BodyPart xref: HAO:0000032 xref: MA:0002433 xref: MAT:0000293 xref: MESH:D001829 xref: MIAA:0000293 xref: NCIT:C32221 xref: TAO:0001308 xref: TGMA:0001840 xref: UMLS:C0229962 {source="ncithesaurus:Body_Part"} xref: VHOG:0001758 xref: Wikipedia:Body_part xref: XAO:0003013 xref: ZFA:0001308 is_a: UBERON:0010000 {source="CARO"} ! multicellular anatomical structure relationship: BFO:0000050 UBERON:0000468 ! part of multicellular organism property_value: IAO:0000116 "Reflects CARO2. todo - check the inclusion of FMA 'cardinal body part here', and check child terms for consistency" xsd:string property_value: RO:0002175 NCBITaxon:33090 property_value: RO:0002175 NCBITaxon:33208 property_value: RO:0002175 NCBITaxon:4751 property_value: skos:prefLabel "organism subdivision" xsd:string [Term] id: UBERON:0000476 name: acellular anatomical structure def: "Anatomical structure that consists of cell parts and cell substances and together does not constitute a cell or a tissue." [http://orcid.org/0000-0001-9114-8737] subset: common_anatomy subset: vertebrate_core synonym: "acellular anatomical structures" RELATED OMO:0003004 [ZFA:0000382] xref: AAO:0010268 xref: AEO:0000040 xref: BILA:0000040 xref: CARO:0000040 xref: EHDAA2:0003040 xref: FBbt:00007013 {sssom:mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"} xref: FMA:63863 xref: HAO:0000040 xref: TAO:0000382 xref: TGMA:0001841 xref: XAO:0003162 xref: ZFA:0000382 is_a: UBERON:0000061 ! anatomical structure disjoint_from: UBERON:0010000 {source="CARO"} ! multicellular anatomical structure property_value: RO:0002175 NCBITaxon:33090 property_value: RO:0002175 NCBITaxon:33208 property_value: RO:0002175 NCBITaxon:4751 property_value: skos:prefLabel "acellular anatomical structure" xsd:string [Term] id: UBERON:0000477 name: anatomical cluster def: "Anatomical group whose component anatomical structures lie in close proximity to each other." [FBbt:00007277] subset: common_anatomy subset: upper_level xref: FBbt:00007277 {sssom:mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"} xref: VHOG:0001737 is_a: UBERON:0034923 ! disconnected anatomical group property_value: RO:0002175 NCBITaxon:33090 property_value: RO:0002175 NCBITaxon:33208 property_value: RO:0002175 NCBITaxon:4751 property_value: skos:prefLabel "anatomical cluster" xsd:string [Term] id: UBERON:0000478 name: extraembryonic structure def: "A multicellular anatomical structure that is associated with an embryo and derived from the zygote from which it develops, but which does not contribute to the embryo proper or to structures that are part of the same organism after embryogenesis." [CARO:DOS, http://orcid.org/0000-0001-9114-8737, https://cedar.bio.indiana.edu/trac/env/ontologies/ticket/279] comment: see also conceptus extraembryonic component in EHDAA2. subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "extra-embryonic structure" EXACT [] synonym: "extraembryonic structures" RELATED OMO:0003004 [ZFA:0000020] synonym: "extraembryonic tissue" RELATED [] xref: AAO:0010020 xref: AEO:0000042 xref: BILA:0000042 xref: CALOHA:TS-2119 xref: CARO:0000042 xref: EHDAA2:0003042 xref: EHDAA:46 xref: FBbt:00005835 {sssom:mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"} xref: FMA:85537 xref: HAO:0000042 xref: NCIT:C34055 xref: SCTID:314908006 xref: TAO:0000020 xref: TGMA:0001843 xref: UMLS:C1282438 {source="ncithesaurus:Extraembryonic_Structure"} xref: VHOG:0000292 xref: XAO:0004005 xref: ZFA:0000020 is_a: UBERON:0005423 ! developing anatomical structure intersection_of: UBERON:0005423 ! developing anatomical structure intersection_of: BFO:0000050 UBERON:0016887 ! part of entire extraembryonic component relationship: BFO:0000050 UBERON:0016887 ! part of entire extraembryonic component property_value: skos:prefLabel "extraembryonic structure" xsd:string [Term] id: UBERON:0000479 name: tissue def: "Multicellular anatomical structure that consists of many cells of one or a few types, arranged in an extracellular matrix such that their long-range organisation is at least partly a repetition of their short-range organisation." [CARO:0000043] subset: common_anatomy subset: pheno_slim subset: upper_level synonym: "portion of tissue" EXACT [CARO:0000043] synonym: "simple tissue" NARROW [AEO:0000043] synonym: "tissue portion" EXACT [] xref: AAO:0000607 xref: AAO:0010054 xref: AEO:0000043 xref: BILA:0000043 xref: BIRNLEX:19 xref: CALOHA:TS-2090 xref: CARO:0000043 xref: EHDAA2:0003043 xref: EMAPA:35868 xref: FBbt:00007003 {sssom:mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"} xref: FMA:9637 xref: galen:Tissue xref: HAO:0000043 xref: MA:0003002 xref: MESH:D014024 xref: NCIT:C12801 xref: TAO:0001477 xref: TGMA:0001844 xref: UMLS:C0040300 {source="ncithesaurus:Tissue"} xref: VHOG:0001757 xref: WBbt:0005729 xref: XAO:0003040 xref: ZFA:0001477 is_a: UBERON:0010000 {source="CARO"} ! multicellular anatomical structure relationship: BFO:0000050 UBERON:0000468 ! part of multicellular organism relationship: BFO:0000051 GO:0031012 ! has part extracellular matrix property_value: IAO:0000116 "changed label and definition to reflect CARO2" xsd:string property_value: RO:0002175 NCBITaxon:33090 property_value: RO:0002175 NCBITaxon:33208 property_value: RO:0002175 NCBITaxon:4751 property_value: skos:prefLabel "tissue" xsd:string [Term] id: UBERON:0000481 name: multi-tissue structure def: "Anatomical structure that has as its parts two or more portions of tissue of at least two different types and which through specific morphogenetic processes forms a single distinct structural unit demarcated by bona-fide boundaries from other distinct structural units of different types." [CARO:0000055, http://orcid.org/0000-0001-9114-8737] subset: common_anatomy subset: upper_level synonym: "multi-tissue structures" RELATED OMO:0003004 [ZFA:0001488] xref: AAO:0010048 xref: AEO:0000055 xref: BILA:0000055 xref: CARO:0000055 xref: EHDAA2:0003055 xref: FBbt:00007010 {sssom:mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"} xref: HAO:0000055 xref: TAO:0001488 xref: TGMA:0001847 xref: VHOG:0001762 xref: XAO:0003037 xref: ZFA:0001488 is_a: UBERON:0010000 {source="CARO"} ! multicellular anatomical structure relationship: BFO:0000051 UBERON:0000479 ! has part tissue property_value: RO:0002175 NCBITaxon:33090 property_value: RO:0002175 NCBITaxon:33208 property_value: RO:0002175 NCBITaxon:4751 property_value: skos:prefLabel "multi-tissue structure" xsd:string [Term] id: UBERON:0000482 name: basal lamina of epithelium def: "Acellular anatomical structure that consists of a thin sheet of fibrous proteins that underlie and support the cells of an epithelium. It separates the cells of an epithelium from any underlying tissue." [http://orcid.org/0000-0001-9114-8737] subset: human_reference_atlas subset: uberon_slim subset: vertebrate_core synonym: "basal lamina" RELATED [CARO:0000065] synonym: "basal lamina of connective tissue" EXACT [FMA:62918] synonym: "basal laminae" RELATED OMO:0003004 [VHOG:0001592] synonym: "lamina basalis" RELATED OMO:0003011 [Wikipedia:Basal_lamina] xref: AAO:0010269 xref: AEO:0000065 xref: BILA:0000065 xref: CARO:0000065 xref: EHDAA2:0003065 xref: FMA:62918 xref: HAO:0000065 xref: MESH:D001485 xref: NCIT:C32186 xref: NIF_Subcellular:sao1397492660 xref: TAO:0001485 xref: TGMA:0001850 xref: UMLS:C0085872 {source="ncithesaurus:Basal_Lamina"} xref: VHOG:0001592 xref: WBbt:0005756 xref: Wikipedia:Basal_lamina xref: XAO:0003163 xref: ZFA:0001485 is_a: UBERON:0005764 {source="FMA"} ! acellular membrane relationship: BFO:0000050 UBERON:0005769 {source="FMA"} ! part of basement membrane of epithelium relationship: RO:0002473 GO:0005604 ! composed primarily of basement membrane property_value: foaf:depiction "https://upload.wikimedia.org/wikipedia/commons/6/65/Basal_lamina.jpg" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "basal lamina of epithelium" xsd:string [Term] id: UBERON:0000483 name: epithelium def: "Portion of tissue, that consists of one or more layers of epithelial cells connected to each other by cell junctions and which is underlain by a basal lamina. Examples: simple squamous epithelium, glandular cuboidal epithelium, transitional epithelium, myoepithelium[CARO]." [http://orcid.org/0000-0001-9114-8737, Wikipedia:Epithelium] comment: Editor note: surface epithelium may contain non-epithelial cells, such as melanocytes, lymphocytes and dendritic cells, within the sheet of epithelial cells. Do we consider these part of the epithelium, or located-in it? subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "epithelial tissue" EXACT [] synonym: "portion of epithelium" EXACT [FMA:9639] xref: AAO:0000144 xref: AAO:0010055 xref: AEO:0000066 xref: BILA:0000066 xref: BTO:0000416 xref: CALOHA:TS-0288 xref: CARO:0000066 xref: EHDAA2:0003066 xref: EMAPA:32738 xref: FBbt:00007005 {sssom:mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"} xref: FMA:9639 xref: GAID:402 xref: HAO:0000066 xref: MA:0003060 xref: MESH:D004848 xref: NCIT:C12710 xref: SCTID:31610004 xref: TAO:0001486 xref: UMLS:C0014609 {source="ncithesaurus:Epithelium"} xref: VHOG:0000387 xref: Wikipedia:Epithelium xref: XAO:0003045 xref: ZFA:0001486 is_a: UBERON:0000479 ! tissue intersection_of: UBERON:0000479 ! tissue intersection_of: RO:0002473 CL:0000066 ! composed primarily of epithelial cell union_of: UBERON:0000486 ! multilaminar epithelium union_of: UBERON:0000490 ! unilaminar epithelium relationship: BFO:0000051 GO:0005911 ! has part cell-cell junction relationship: BFO:0000051 UBERON:0005769 ! has part basement membrane of epithelium relationship: RO:0002473 CL:0000066 ! composed primarily of epithelial cell property_value: foaf:depiction "https://upload.wikimedia.org/wikipedia/commons/8/8f/Illu_epithelium.jpg" xsd:anyURI property_value: skos:prefLabel "epithelium" xsd:string [Term] id: UBERON:0000484 name: simple cuboidal epithelium def: "Unilaminar epithelium that consists of a single layer of cuboidal cells." [http://orcid.org/0000-0001-9114-8737, Wikipedia:Simple_cuboidal_epithelium] subset: uberon_slim subset: vertebrate_core synonym: "epithelium simplex cuboideum" EXACT [] synonym: "simple cuboidal epithelia" RELATED OMO:0003004 [ZFA:0001497] xref: AAO:0010064 xref: AEO:0000067 xref: BILA:0000067 xref: CARO:0000067 xref: EHDAA2:0003067 xref: FMA:45566 xref: HAO:0000067 xref: NCIT:C33553 xref: TAO:0001497 xref: UMLS:C0836134 {source="ncithesaurus:Simple_Cuboidal_Epithelium"} xref: Wikipedia:Simple_cuboidal_epithelium xref: XAO:0004009 xref: ZFA:0001497 is_a: UBERON:0000490 ! unilaminar epithelium is_a: UBERON:0010077 ! cuboidal epithelium property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/d/d0/Gray1133.png" xsd:anyURI property_value: IAO:0000116 "needs to be synchronized with CL - there is no distinct cuboidal cell in CL" xsd:string property_value: skos:prefLabel "simple cuboidal epithelium" xsd:string [Term] id: UBERON:0000485 name: simple columnar epithelium def: "Unilaminar epithelium, which consists of a single layer of columnar cells. Examples: ciliated columnar epithelium, gastric epithelium, microvillus columnar epithelium.[FMA]." [FMA:FMA, http://orcid.org/0000-0001-9114-8737, Wikipedia:Simple_columnar_epithelium] subset: uberon_slim subset: vertebrate_core synonym: "columnar epithelium" BROAD [EHDAA2:0003068] synonym: "columnar epithlium" BROAD [AEO:0000068] synonym: "epithelium simplex columnare" EXACT [] synonym: "simple columnar epithelia" RELATED OMO:0003004 [ZFA:0001496] synonym: "simple columnar epithelium" EXACT [] xref: AAO:0010063 xref: AEO:0000068 xref: BILA:0000068 xref: CARO:0000068 xref: EHDAA2_RETIRED:0003068 xref: FBbt:00007027 {sssom:mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"} xref: FMA:45567 xref: HAO:0000068 xref: NCIT:C33552 xref: SCTID:32210007 xref: TAO:0001496 xref: UMLS:C0836135 {source="ncithesaurus:Simple_Columnar_Epithelium"} xref: Wikipedia:Simple_columnar_epithelium xref: XAO:0004008 xref: ZFA:0001496 is_a: UBERON:0000490 ! unilaminar epithelium is_a: UBERON:0012274 ! columnar epithelium property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/8/8b/Gray1059.png" xsd:anyURI property_value: skos:prefLabel "simple columnar epithelium" xsd:string [Term] id: UBERON:0000486 name: multilaminar epithelium def: "Epithelium which consists of more than one layer of epithelial cells that may or may not be in contact with a basement membrane. Examples: keratinized stratified squamous epithelium, ciliated stratified columnar epithelium.[FMA]." [FMA:FMA, http://orcid.org/0000-0001-9114-8737, Wikipedia:Stratified_epithelium] subset: uberon_slim subset: vertebrate_core synonym: "laminated epithelium" RELATED [BTO:0002074] synonym: "stratified epithelium" EXACT [] xref: AAO:0010059 xref: AEO:0000069 xref: BILA:0000069 xref: BTO:0002074 xref: CARO:0000069 xref: EHDAA2:0003069 xref: FMA:45562 xref: HAO:0000069 xref: NCIT:C33622 xref: SCTID:309044005 xref: TAO:0001494 xref: UMLS:C0682575 {source="ncithesaurus:Stratified_Epithelium"} xref: Wikipedia:Stratified_epithelium xref: XAO:0004006 xref: ZFA:0001494 is_a: UBERON:0000483 ! epithelium property_value: skos:prefLabel "multilaminar epithelium" xsd:string [Term] id: UBERON:0000487 name: simple squamous epithelium def: "Unilaminar epithelium which consists of a single layer of squamous cells. Examples: pulmonary alveolar epithelium, endothelium.[FMA]." [FMA:45565, http://orcid.org/0000-0001-9114-8737, Wikipedia:Simple_squamous_epithelium] subset: uberon_slim subset: vertebrate_core synonym: "epithelium simplex squamosum" EXACT [] synonym: "simple squamous epithelia" RELATED OMO:0003004 [ZFA:0001498] xref: AAO:0010066 xref: AEO:0000070 xref: BILA:0000070 xref: BTO:0002073 xref: CARO:0000070 xref: EHDAA2:0003070 xref: FMA:45565 xref: HAO:0000070 xref: NCIT:C13178 xref: TAO:0001498 xref: UMLS:C0836133 {source="ncithesaurus:Simple_Squamous_Epithelium"} xref: Wikipedia:Simple_squamous_epithelium xref: XAO:0004010 xref: ZFA:0001498 is_a: UBERON:0000490 ! unilaminar epithelium is_a: UBERON:0006914 ! squamous epithelium intersection_of: UBERON:0000490 ! unilaminar epithelium intersection_of: RO:0002473 CL:0000076 ! composed primarily of squamous epithelial cell property_value: foaf:depiction "https://upload.wikimedia.org/wikipedia/commons/8/8f/Illu_epithelium.jpg" xsd:anyURI property_value: skos:prefLabel "simple squamous epithelium" xsd:string [Term] id: UBERON:0000488 name: atypical epithelium def: "Epithelium that consists of epithelial cells not arranged in one ore more layers." [http://orcid.org/0000-0001-9114-8737] subset: vertebrate_core synonym: "atypical epithelia" RELATED OMO:0003004 [ZFA:0001493] synonym: "heterogenous epithelium" EXACT [] xref: AAO:0010057 xref: AEO:0000071 xref: BILA:0000071 xref: CARO:0000071 xref: EHDAA2:0003071 xref: FMA:61741 xref: HAO:0000071 xref: TAO:0001493 xref: XAO:0004004 xref: ZFA:0001493 is_a: UBERON:0000483 ! epithelium property_value: skos:prefLabel "atypical epithelium" xsd:string [Term] id: UBERON:0000489 name: cavitated compound organ def: "Compound organ that contains one or more macroscopic anatomical spaces." [http://orcid.org/0000-0001-9114-8737] subset: organ_slim subset: upper_level synonym: "cavitated compound organs" RELATED OMO:0003004 [ZFA:0001490] synonym: "cavitated organ" EXACT [FMA:55671] xref: AAO:0010016 xref: AEO:0000072 xref: BILA:0000072 xref: CARO:0000072 xref: EHDAA2:0003072 xref: FMA:55671 xref: HAO:0000072 xref: TAO:0001490 xref: TGMA:0001857 xref: VHOG:0001730 xref: XAO:0003165 xref: ZFA:0001490 is_a: UBERON:0003103 ! compound organ intersection_of: UBERON:0003103 ! compound organ intersection_of: BFO:0000051 UBERON:0002553 ! has part anatomical cavity relationship: BFO:0000051 UBERON:0002553 ! has part anatomical cavity property_value: skos:prefLabel "cavitated compound organ" xsd:string [Term] id: UBERON:0000490 name: unilaminar epithelium def: "Epithelium which consists of a single layer of epithelial cells. Examples: endothelium, mesothelium, glandular squamous epithelium.[FMA]." [FMA:45561, http://orcid.org/0000-0001-9114-8737] subset: vertebrate_core synonym: "simple epithelium" EXACT [FMA:45561] synonym: "unilaminar epithelia" RELATED OMO:0003004 [ZFA:0001495] xref: AAO:0010062 xref: AEO:0000073 xref: BILA:0000073 xref: BTO:0002073 xref: CARO:0000073 xref: EHDAA2:0003073 xref: FMA:45561 xref: HAO:0000073 xref: NCIT:C33554 xref: SCTID:309043004 xref: TAO:0001495 xref: UMLS:C0682574 {source="ncithesaurus:Simple_Epithelium"} xref: XAO:0004007 xref: ZFA:0001495 is_a: UBERON:0000483 ! epithelium property_value: IAO:0000116 "consider adding disjointness axiom between unilaminar and multilaminar - but note that this will render EHDAA2:0003244 (chorionic trophoblast) unsatisfiable" xsd:string property_value: skos:prefLabel "unilaminar epithelium" xsd:string [Term] id: UBERON:0000912 name: mucus def: "Mucus is a bodily fluid consisting of a slippery secretion of the lining of the mucous membranes in the body. It is a viscous colloid containing antiseptic enzymes (such as lysozyme) and immunoglobulins. Mucus is produced by goblet cells in the mucous membranes that cover the surfaces of the membranes. It is made up of mucins and inorganic salts suspended in water." [Wikipedia:Mucus] xref: CALOHA:TS-2144 xref: ENVO:02000040 xref: FMA:66938 xref: GAID:1164 xref: galen:Mucus xref: MESH:D009093 xref: NCIT:C13259 xref: UMLS:C0026727 {source="ncithesaurus:Mucus"} xref: Wikipedia:Mucus is_a: UBERON:0000456 ! secretion of exocrine gland is_a: UBERON:0006314 ! bodily fluid relationship: BFO:0000051 CHEBI:37395 ! has part relationship: RO:0000086 PATO:0000998 ! has quality viscous relationship: RO:0003001 UBERON:0000344 ! produced by mucosa property_value: skos:prefLabel "mucus" xsd:string [Term] id: UBERON:0000913 name: interstitial fluid def: "Interstitial fluid is a bodily fluid consisting of a solution which bathes and surrounds the cells of multicellular animals. It is the main component of the extracellular fluid, which also includes plasma and transcellular fluid." [Wikipedia:Interstitial_fluid] subset: pheno_slim synonym: "intercellular fluid" EXACT [ENVO:02000042] synonym: "tissue fluid" EXACT [ENVO:02000042] xref: ENVO:02000042 xref: FMA:9673 xref: NCIT:C120839 xref: Wikipedia:Interstitial_fluid is_a: UBERON:0000463 ! organism substance relationship: BFO:0000050 UBERON:0000479 ! part of tissue relationship: RO:0002162 NCBITaxon:6072 ! in taxon Eumetazoa relationship: RO:0002221 CL:0000000 ! surrounds cell [Term] id: UBERON:0000915 name: thoracic segment of trunk def: "Subdivision of trunk that lies between the head and the abdomen." [http://orcid.org/0000-0002-6601-2165] subset: uberon_slim synonym: "anterior subdivision of trunk" RELATED [] synonym: "thorax" EXACT [MA:0000022] synonym: "upper body" RELATED [] synonym: "upper trunk" RELATED [FMA:259209] xref: EMAPA:35862 xref: FMA:259209 xref: MA:0000022 xref: SCTID:302551006 xref: Wikipedia:Thorax is_a: UBERON:0009569 {source="FMA"} ! subdivision of trunk is_a: UBERON:0011676 ! subdivision of organism along main body axis intersection_of: UBERON:0011676 ! subdivision of organism along main body axis intersection_of: RO:0002551 UBERON:0014477 ! has skeleton thoracic skeleton relationship: RO:0002551 UBERON:0014477 ! has skeleton thoracic skeleton property_value: skos:prefLabel "thoracic segment of trunk" xsd:string [Term] id: UBERON:0000916 name: abdomen def: "The subdivision of the vertebrate body between the thorax and pelvis. The ventral part of the abdomen contains the abdominal cavity and visceral organs. The dorsal part includes the abdominal section of the vertebral column." [http://orcid.org/0000-0002-6601-2165] subset: efo_slim subset: pheno_slim subset: uberon_slim synonym: "abdominopelvic region" EXACT [FMA:9577] synonym: "abdominopelvis" EXACT [FMA:9577] synonym: "adult abdomen" RELATED [] synonym: "belly" RELATED [] synonym: "celiac region" RELATED [] xref: BTO:0000020 xref: CALOHA:TS-0001 xref: EFO:0000968 xref: EMAPA:35102 xref: EV:0100011 xref: FMA:9577 xref: GAID:16 xref: galen:Abdomen xref: MA:0000029 xref: MAT:0000298 xref: MESH:D000005 xref: MIAA:0000298 xref: SCTID:302553009 xref: Wikipedia:Abdomen is_a: UBERON:0009569 ! subdivision of trunk relationship: BFO:0000050 UBERON:0002417 {source="MA"} ! part of abdominal segment of trunk relationship: RO:0002162 NCBITaxon:7742 ! in taxon Vertebrata property_value: IAO:0000116 "Vertebrate specific. In arthropods 'abdomen' is the most distal section of the body which lies behind the thorax or cephalothorax. If need be we can introduce some grouping class" xsd:string property_value: skos:prefLabel "abdomen" xsd:string [Term] id: UBERON:0000922 name: embryo def: "Anatomical entity that comprises the organism in the early stages of growth and differentiation that are characterized by cleavage, the laying down of fundamental tissues, and the formation of primitive organs and organ systems. For example, for mammals, the process would begin with zygote formation and end with birth. For insects, the process would begin at zygote formation and end with larval hatching. For plant zygotic embryos, this would be from zygote formation to the end of seed dormancy. For plant vegetative embryos, this would be from the initial determination of the cell or group of cells to form an embryo until the point when the embryo becomes independent of the parent plant." [BTO:0000379, FB:FBrf0039741, FB:FBrf0041814, GO:0009790, Wikipedia:Embryo] subset: efo_slim subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "developing organism" RELATED [BILA:0000056] synonym: "developmental tissue" RELATED [] synonym: "embryonic organism" EXACT [BILA:0000056] xref: AAO:0011035 xref: AEO:0000169 xref: BILA:0000056 xref: BSA:0000039 xref: BTO:0000379 xref: CALOHA:TS-0229 xref: EFO:0001367 xref: EHDAA2:0000002 xref: EHDAA2_RETIRED:0003236 xref: EHDAA:38 xref: EMAPA:16039 xref: FBbt:00000052 {sssom:mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"} xref: FMA:69068 xref: GAID:963 xref: http://neurolex.org/wiki/Category\:Embryonic_organism xref: MAT:0000226 xref: MESH:D004622 xref: MIAA:0000019 xref: NCIT:C28147 xref: OGEM:000001 xref: SCTID:57991002 xref: UMLS:C0013935 {source="ncithesaurus:Embryo"} xref: VHOG:0001766 xref: Wikipedia:Embryo xref: XAO:0000113 xref: ZFA:0000103 is_a: UBERON:0000468 ! multicellular organism intersection_of: UBERON:0000468 ! multicellular organism intersection_of: RO:0002489 UBERON:0000068 ! existence starts with embryo stage intersection_of: RO:0002493 UBERON:0000068 ! existence ends with embryo stage relationship: RO:0002489 UBERON:0000068 ! existence starts with embryo stage relationship: RO:0002493 UBERON:0000068 ! existence ends with embryo stage property_value: foaf:depiction "https://upload.wikimedia.org/wikipedia/commons/2/2d/Wrinkledfrog_embryos.jpg" xsd:anyURI property_value: seeAlso "https://github.com/obophenotype/uberon/issues/503" xsd:anyURI property_value: skos:prefLabel "embryo" xsd:string [Term] id: UBERON:0000923 name: germ layer def: "A layer of cells produced during the process of gastrulation during the early development of the animal embryo, which is distinct from other such layers of cells, as an early step of cell differentiation. The three types of germ layers are the endoderm, ectoderm, and mesoderm." [https://github.com/obophenotype/uberon/issues/203, Wikipedia:Germ_layer] comment: Classically the germ layers are ectoderm, mesoderm and endoderm. Alternatively: primary = ectoderm, endoderm; secondary=mesoderm; tertiary=dorsal mesoderm, NC[https://github.com/obophenotype/uberon/wiki/The-neural-crest] subset: uberon_slim subset: vertebrate_core synonym: "embryonic germ layer" RELATED [] synonym: "embryonic germ layers" RELATED [] synonym: "embryonic tissue" BROAD [FMA:69069] synonym: "germinal layer" EXACT [ncithesaurus:Germinal_Layer] synonym: "primary germ layer" NARROW [GO:0001704, ZFA:0001122] xref: AAO:0000480 xref: BILA:0000035 xref: BTO:0000556 xref: EMAPA:36033 xref: FBbt:00000110 {sssom:mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"} xref: FMA:69069 xref: GAID:1303 xref: MESH:D005855 xref: NCIT:C12950 xref: NCIT:C54105 xref: TAO:0001122 xref: UMLS:C0920502 {source="ncithesaurus:Embryonic_Tissue"} xref: UMLS:C1708239 {source="ncithesaurus:Germinal_Layer"} xref: VHOG:0001223 xref: Wikipedia:Germ_layer xref: XAO:0003011 xref: ZFA:0001122 is_a: UBERON:0010316 ! germ layer / neural crest relationship: RO:0002162 NCBITaxon:6072 ! in taxon Eumetazoa property_value: skos:prefLabel "germ layer" xsd:string [Term] id: UBERON:0000924 name: ectoderm def: "Primary germ layer that is the outer of the embryo's three germ layers and gives rise to epidermis and neural tissue." [Wikipedia:Ectoderm] subset: efo_slim subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "embryonic ectoderm" EXACT [VHOG:0000153] xref: AAO:0000137 xref: BILA:0000036 xref: BTO:0000315 xref: CALOHA:TS-0216 xref: EFO:0000414 xref: EHDAA2:0000428 xref: EMAPA:16069 xref: EV:0100003 xref: FBbt:00000111 {sssom:mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"} xref: FMA:69070 xref: GAID:1304 xref: MAT:0000155 xref: MAT:0000173 xref: MESH:D004475 xref: MIAA:0000173 xref: NCIT:C12703 xref: SCTID:362851007 xref: TAO:0000016 xref: UMLS:C0013574 {source="ncithesaurus:Ectoderm"} xref: VHOG:0000153 xref: Wikipedia:Ectoderm xref: XAO:0000001 xref: ZFA:0000016 is_a: UBERON:0000923 ! germ layer relationship: BFO:0000051 CL:0000221 ! has part ectodermal cell relationship: RO:0002495 UBERON:0006601 {source="Bgee:AN"} ! immediate transformation of presumptive ectoderm property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/1/19/Gray32.png" xsd:anyURI property_value: skos:prefLabel "ectoderm" xsd:string [Term] id: UBERON:0000925 name: endoderm def: "Primary germ layer that lies remote from the surface of the embryo and gives rise to internal tissues such as gut." [Wikipedia:Endoderm] subset: efo_slim subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "entoderm" RELATED DEPRECATED [DOI:10.5962/bhl.title.1013] xref: AAO:0000139 xref: BILA:0000038 xref: BTO:0000800 xref: CALOHA:TS-0273 xref: EFO:0002545 xref: EHDAA2:0000436 xref: EMAPA:16062 xref: EV:0100005 xref: FBbt:00000125 {sssom:mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"} xref: FMA:69071 xref: GAID:1305 xref: MAT:0000175 xref: MESH:D004707 xref: MIAA:0000175 xref: NCIT:C12706 xref: SCTID:362855003 xref: TAO:0000017 xref: UMLS:C0014144 {source="ncithesaurus:Endoderm"} xref: VHOG:0000154 xref: Wikipedia:Endoderm xref: XAO:0000090 xref: ZFA:0000017 is_a: UBERON:0000923 ! germ layer relationship: BFO:0000051 CL:0000223 ! has part endodermal cell relationship: RO:0002495 UBERON:0006595 {source="Bgee:AN"} ! immediate transformation of presumptive endoderm property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/c/c0/Endoderm2.png" xsd:anyURI property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/d/df/Gray10.png" xsd:anyURI property_value: skos:prefLabel "endoderm" xsd:string [Term] id: UBERON:0000926 name: mesoderm def: "The middle germ layer of the embryo, between the endoderm and ectoderm." [Wikipedia:Mesoderm] subset: efo_slim subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "embryonic mesoderm" RELATED [VHOG:0000152] synonym: "entire mesoderm" RELATED [https://orcid.org/0000-0002-6601-2165, SCTID:362854004] synonym: "mesodermal mantle" RELATED [] xref: AAO:0000304 xref: BILA:0000037 xref: BTO:0000839 xref: CALOHA:TS-0623 xref: EFO:0001981 xref: EHDAA2:0001128 xref: EHDAA:124 xref: EHDAA:160 xref: EHDAA:183 xref: EMAPA:16083 xref: EV:0100006 xref: FBbt:00000126 {sssom:mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"} xref: FMA:69072 xref: GAID:522 xref: MAT:0000174 xref: MESH:D008648 xref: MIAA:0000174 xref: NCIT:C12750 xref: SCTID:362854004 xref: TAO:0000041 xref: UMLS:C0025485 {source="ncithesaurus:Mesoderm"} xref: VHOG:0000152 xref: Wikipedia:Mesoderm xref: XAO:0000050 xref: ZFA:0000041 is_a: UBERON:0000923 ! germ layer relationship: BFO:0000051 CL:0000222 ! has part mesodermal cell relationship: RO:0002495 UBERON:0006603 {source="Bgee:AN"} ! immediate transformation of presumptive mesoderm property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/e/e8/Mesoderm.png" xsd:anyURI property_value: RO:0002161 NCBITaxon:6040 property_value: skos:prefLabel "mesoderm" xsd:string [Term] id: UBERON:0000930 name: stomodeum def: "Anterior part of the embryonic digestive tract that develops into a mouth. The stomodeum includes as parts an invagination of the ectoderm and the stomodeal cavity." [http://orcid.org/0000-0002-6601-2165, https://github.com/obophenotype/uberon/issues/326, Wikipedia:Stomodeum] subset: grouping_class subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "mouth pit" RELATED [EMAPA:16263] synonym: "mouth primordium" EXACT [XAO:0000269] synonym: "oral ectoderm" RELATED [ZFA:0001290, ZFIN:ZDB-PUB-100726-23] synonym: "oral pit" RELATED [EMAPA:16263] synonym: "primitive oral cavity" EXACT [https://orcid.org/0000-0002-6601-2165] synonym: "stomatodeum" EXACT [Wikipedia:Stomodeum] synonym: "stomodaeum" EXACT [] synonym: "stomodeal-hypophyseal primordium" BROAD [XAO:0000269] xref: BTO:0004224 xref: EHDAA2:0001929 xref: EMAPA:16263 xref: FBbt:00000439 {sssom:mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"} xref: FMA:295846 xref: NCIT:C34306 xref: TAO:0001290 xref: TGMA:0000135 xref: UMLS:C1514977 {source="ncithesaurus:Stomodeum"} xref: Wikipedia:Stomodeum xref: XAO:0000269 xref: ZFA:0001290 is_a: UBERON:0013522 ! subdivision of tube relationship: BFO:0000050 UBERON:0000924 ! part of ectoderm relationship: BFO:0000050 UBERON:0035804 ! part of future mouth property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/9/93/Gray977.png" xsd:anyURI property_value: IAO:0000116 "consider indicating location. e.g. anterior. Note some AOs place this as part of oral opening, but it's not clear when this structure comes into existence" xsd:string property_value: skos:prefLabel "stomodeum" xsd:string [Term] id: UBERON:0000931 name: proctodeum def: "Inward fold on the surface of the embryonic ectoderm that develops into an ectodermal terminal part of the digestive tract." [https://github.com/obophenotype/uberon/issues/685, https://sourceforge.net/p/fbbtdv/tickets/52, ZFA:0000066] subset: uberon_slim synonym: "amnioproctodeal invagination" NARROW [FBbt:00000123] synonym: "anal pit" RELATED [VHOG:0000139] synonym: "anus porus" RELATED [XAO:0001019] synonym: "embryonic proctodaeum" EXACT [] synonym: "proctodaeum" EXACT [] xref: AAO:0011087 xref: EHDAA2:0000121 xref: EMAPA:25038 xref: FBbt:00000123 {sssom:mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"} xref: NCIT:C34278 xref: TAO:0000066 xref: UMLS:C0231054 {source="ncithesaurus:Proctodeum"} xref: VHOG:0000139 xref: Wikipedia:Proctodeum xref: XAO:0001019 xref: ZFA:0000066 is_a: BFO:0000002 is_a: UBERON:0016566 {source="EHDAA2"} ! pit relationship: BFO:0000050 UBERON:0007026 ! part of presumptive gut relationship: RO:0001025 UBERON:0012469 {source="EHDAA2"} ! located in external anal region relationship: RO:0002202 UBERON:0000924 ! develops from ectoderm relationship: RO:0002387 UBERON:0001353 ! has potential to develop into anal region property_value: IAO:0000116 "removed WBbt:0006795 'proctodeum' - junction between the alimentary and genital tracts in the male." xsd:string property_value: seeAlso "https://github.com/obophenotype/uberon/issues/685" xsd:anyURI property_value: skos:prefLabel "proctodeum" xsd:string property_value: terms:contributor https://orcid.org/0000-0001-5948-3092 property_value: terms:contributor https://orcid.org/0000-0002-6601-2165 property_value: terms:contributor https://orcid.org/0000-0002-7073-9172 property_value: terms:contributor https://orcid.org/0000-0003-3308-6245 [Term] id: UBERON:0000933 name: chordate pharyngeal muscle def: "A muscle that acts on the pharynx[WP, vetted]." [https://orcid.org/0000-0002-6601-2165, Wikipedia:Pharyngeal_muscles] comment: Innervation notes: They are innervated by the pharyngeal branch of the Vagus nerve (CN X) with the exception of the stylopharyngeus muscle which is innervated by the glossopharyngeal nerve (CN IX).[WP] subset: efo_slim subset: pheno_slim synonym: "branchial muscle" EXACT [ZFA:0000172] synonym: "branchial muscles" RELATED OMO:0003004 [TAO:0000172] synonym: "muscle of pharynx" EXACT [] synonym: "muscle organ of pharynx" EXACT [OBOL:automatic] synonym: "musculi pharyngis" RELATED OMO:0003011 [Wikipedia:Pharyngeal_muscles] synonym: "musculus pharyngis" RELATED [BTO:0001048] synonym: "pharyngeal muscle" EXACT [] synonym: "pharynx muscle" EXACT [] synonym: "pharynx muscle organ" EXACT [OBOL:automatic] synonym: "tunica muscularis pharyngis" RELATED OMO:0003011 [Wikipedia:Pharyngeal_muscles] xref: BTO:0001048 xref: EFO:0003504 xref: FMA:46619 xref: GAID:154 xref: MA:0001797 xref: MESH:D010609 xref: NCIT:C13075 xref: SCTID:244798004 xref: TAO:0000172 xref: UMLS:C0031346 {source="ncithesaurus:Pharyngeal_Muscle"} xref: Wikipedia:Pharyngeal_muscles xref: ZFA:0000172 is_a: UBERON:0001630 ! muscle organ intersection_of: UBERON:0001630 ! muscle organ intersection_of: BFO:0000050 UBERON:0004467 ! part of musculature of pharynx relationship: BFO:0000050 UBERON:0004467 ! part of musculature of pharynx relationship: RO:0002433 UBERON:0001015 ! contributes to morphology of musculature property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/3/35/Gray1030.png" xsd:anyURI [Term] id: UBERON:0000936 name: posterior commissure def: "Rounded band of white fibers crossing the middle line on the dorsal aspect of the upper end of the cerebral aqueduct. It is important in the bilateral pupillary light reflex. Its fibers acquire their medullary sheaths early, but their connections have not been definitely determined. Most of them have their origin in a nucleus, the nucleus of the posterior commissure (nucleus of Darkschewitsch), which lies in the central gray substance of the upper end of the cerebral aqueduct, in front of the nucleus of the oculomotor nerve. Some are probably derived from the posterior part of the thalamus and from the superior colliculus, whereas others are believed to be continued downward into the medial longitudinal fasciculus. The posterior commissure interconnects the pretectal nuclei, mediating the consensual pupillary light reflex[WP]. Diencephalic tract which is located in the vicinity of the dorsal diencephalon and mesencephalon and connects the pretectal nuclei. From Neuroanatomy of the Zebrafish Brain[ZFA]." [Wikipedia:Posterior_commissure, ZFA:0000320] subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "caudal commissure" EXACT [FMA:62072, ZFA:0000320] synonym: "commissura epithalami" RELATED OMO:0003011 [NeuroNames:484] synonym: "commissura epithalamica" RELATED OMO:0003011 [NeuroNames:484] synonym: "commissura posterior" RELATED OMO:0003011 [Wikipedia:Posterior_commissure] synonym: "epithalamic commissure" EXACT [FMA:62072] synonym: "posterior commissure (Lieutaud)" RELATED [NeuroNames:484] xref: BAMS:PC xref: BAMS:pc xref: BIRNLEX:1026 xref: BM:MB-Tec-PC xref: DHBA:10567 xref: DMBA:17787 xref: EMAPA:35695 xref: FMA:62072 xref: HBA:9229 xref: MA:0002743 xref: MBA:158 xref: NCIT:C33356 xref: neuronames:484 {source="BIRNLEX:1026"} xref: TAO:0000320 xref: UMLS:C0152327 {source="BIRNLEX:1026", source="ncithesaurus:Posterior_Commissure"} xref: Wikipedia:Posterior_commissure xref: ZFA:0000320 is_a: UBERON:0011590 ! commissure of diencephalon intersection_of: UBERON:0001020 ! nervous system commissure intersection_of: RO:0002176 UBERON:0014450 ! connects pretectal nucleus relationship: BFO:0000050 UBERON:0003931 {source="FMA"} ! part of diencephalic white matter relationship: RO:0002162 NCBITaxon:7742 ! in taxon Vertebrata relationship: RO:0002176 UBERON:0014450 ! connects pretectal nucleus property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/d/d7/Gray715.png" xsd:anyURI property_value: IAO:0000116 "add connects relationships and check these outside mammalia" xsd:string property_value: skos:prefLabel "posterior commissure" xsd:string [Term] id: UBERON:0000939 name: imaginal disc def: "One of the parts of a holometabolous insect larva that will become a portion of the outside of the adult insect during the pupal transformation." [Wikipedia:Imaginal_disc] comment: Though inaginal discs are sometimes described as “epithelial sacs”, we do not classify them as such, because an “epithelial sac” is defined in Uberon as being a single epithelium, whereas imaginal discs are made of several epithelia with distinct properties. subset: uberon_slim synonym: "imaginal disk" RELATED [] xref: BTO:0004658 xref: FBbt:00001761 {sssom:mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"} xref: MAT:0000064 xref: MIAA:0000064 xref: Wikipedia:Imaginal_disc is_a: UBERON:0000481 {source="FBbt text definition"} ! multi-tissue structure relationship: BFO:0000050 UBERON:0002548 ! part of larva relationship: RO:0002162 NCBITaxon:50557 {source="Wikipedia"} ! in taxon Insecta [Term] id: UBERON:0000941 name: cranial nerve II def: "Cranial nerve fiber tract which is comprised of retinal ganglion cell axons running posterior medially towards the optic chiasm, at which some of the axons cross the midline and after which the structure is termed the optic tract. Transmits visual information from the retina to the brain[ZFA]." [ISBN:0471209627, ISBN:0471888893] subset: efo_slim subset: human_reference_atlas subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "02 optic nerve" EXACT [AAO:0010345] synonym: "2n" BROAD OMO:0003000 [BIRNLEX:1640, NIFSTD:NeuroNames_abbrevSource] synonym: "CN-II" RELATED [ZFA:0000435] synonym: "cranial II" EXACT [] synonym: "nerve II" RELATED [NeuroNames:289] synonym: "nervus opticus" EXACT OMO:0003011 [] synonym: "nervus opticus [II]" EXACT OMO:0003011 [FMA:50863, FMA:TA] synonym: "optic" RELATED [TAO:0000435] synonym: "optic II" EXACT [EHDAA2:0001313] synonym: "optic II nerve" EXACT [EHDAA2:0001313] synonym: "optic nerve" BROAD SENSU [FMA:50863, ZFA:0000435] synonym: "optic nerve [II]" EXACT [] synonym: "second cranial nerve" EXACT [] xref: AAO:0010345 xref: BAMS:2n xref: BAMS:IIn xref: BAMS:nII xref: BIRNLEX:1640 xref: CALOHA:TS-0713 xref: DHBA:15544 xref: EFO:0004258 xref: EHDAA2:0001313 xref: EHDAA:6788 xref: EMAPA:17575 xref: FMA:50863 xref: GAID:831 xref: HBA:9307 xref: MA:0001097 xref: MBA:848 xref: MESH:D009900 xref: NCIT:C12761 xref: neuronames:289 {source="BIRNLEX:1640"} xref: SCTID:180938001 xref: TAO:0000435 xref: UMLS:C0029130 {source="ncithesaurus:Optic_Nerve", source="BIRNLEX:1640"} xref: VHOG:0000543 xref: Wikipedia:Optic_nerve xref: XAO:0000188 xref: ZFA:0000435 is_a: UBERON:0004121 ! ectoderm-derived structure is_a: UBERON:0011215 ! central nervous system cell part cluster is_a: UBERON:0034713 ! cranial neuron projection bundle intersection_of: UBERON:0034713 ! cranial neuron projection bundle intersection_of: extends_fibers_into UBERON:0000959 ! optic chiasma intersection_of: RO:0002134 UBERON:0000966 ! innervates retina relationship: BFO:0000050 UBERON:0002104 ! part of visual system relationship: extends_fibers_into UBERON:0000959 ! optic chiasma relationship: extends_fibers_into UBERON:0003098 ! optic stalk relationship: RO:0002134 UBERON:0000966 ! innervates retina relationship: RO:0002202 UBERON:0003902 {source="EHDAA2"} ! develops from retinal neural layer property_value: IAO:0000116 "Do not classify under 'cranial nerve', as this is not a true nerve - should be classified as evaginated sensory afferent[ISBN:0471888893]" xsd:string property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "cranial nerve II" xsd:string [Term] id: UBERON:0000945 name: stomach def: "An expanded region of the vertebrate alimentary tract that serves as a food storage compartment and digestive organ. A stomach is lined, in whole or in part by a glandular epithelium." [https://orcid.org/0000-0002-6601-2165, ISBN:0073040584, Wikipedia:Stomach] subset: efo_slim subset: human_reference_atlas subset: major_organ subset: organ_slim subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "anterior intestine" RELATED [] synonym: "gaster" RELATED [BTO:0001307] synonym: "mesenteron" RELATED [] synonym: "stomach chamber" NARROW [] synonym: "ventriculus" RELATED OMO:0003011 [Wikipedia:Stomach] xref: AAO:0000579 xref: ANISEED:1235297 xref: BTO:0001307 xref: CALOHA:TS-0980 xref: EFO:0000837 xref: EHDAA2:0001915 xref: EHDAA:2993 xref: EMAPA:17021 xref: EV:0100070 xref: FMA:7148 xref: GAID:293 xref: galen:Stomach xref: MA:0000353 xref: MAT:0000051 xref: MESH:D013270 xref: MIAA:0000051 xref: NCIT:C12391 xref: SCTID:181246003 xref: TAO:0002121 xref: UMLS:C0038351 {source="ncithesaurus:Stomach"} xref: VHOG:0000408 xref: Wikipedia:Stomach xref: XAO:0000128 is_a: UBERON:0004921 {source="cjm"} ! subdivision of digestive tract is_a: UBERON:0010039 {source="cjm"} ! food storage organ relationship: BFO:0000050 UBERON:0001041 ! part of foregut relationship: RO:0002162 NCBITaxon:7776 ! in taxon Gnathostomata relationship: RO:0002215 GO:0001696 {evidence="ISBN:0486692132"} ! capable of gastric acid secretion relationship: RO:0002433 UBERON:0001007 ! contributes to morphology of digestive system property_value: foaf:depiction "https://upload.wikimedia.org/wikipedia/commons/e/e0/Stomach_diagram.svg" xsd:anyURI property_value: RO:0002161 NCBITaxon:7864 {source="Wikipedia"} property_value: RO:0002161 NCBITaxon:7878 {source="Wikipedia"} property_value: RO:0002161 NCBITaxon:7955 {source="ZFA"} property_value: RO:0002161 NCBITaxon:9259 {source="Wikipedia"} property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "stomach" xsd:string [Term] id: UBERON:0000946 name: cardiac valve def: "A membranous fold of the heart that prevents reflux of fluid." [MESH:A07.541.510, MP:0000285, PMID:7926784] subset: human_reference_atlas subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "heart valve" EXACT [] synonym: "heart valve" RELATED [XAO:0004126] synonym: "heart valves" RELATED [] synonym: "stomodaeal valve" RELATED [] synonym: "valve of heart" EXACT [] synonym: "valvule" RELATED [] xref: BTO:0000564 xref: EMAPA:17869 xref: EV:0100024 xref: FMA:7110 xref: GAID:176 xref: galen:HeartValve xref: MA:0000086 xref: MESH:D006351 xref: NCIT:C12729 xref: SCTID:181285005 xref: TAO:0005065 xref: UMLS:C0018826 {source="ncithesaurus:Cardiac_Valve"} xref: VHOG:0000818 xref: Wikipedia:Cardiac_valve xref: XAO:0004126 xref: ZFA:0005065 is_a: UBERON:0003978 ! valve is_a: UBERON:0010313 ! neural crest-derived structure relationship: BFO:0000050 UBERON:0000948 ! part of heart relationship: RO:0002202 UBERON:0002062 {source="PMID:15797462"} ! develops from endocardial cushion property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0000947 name: aorta def: "The main trunk of the systemic arterial system that carries blood from the heart to all the organs and other structures of the body, bringing oxygenated blood to all parts of the body in the systemic circulation." [http://orcid.org/0000-0002-6601-2165, ISBN:0-683-40008-8, MESH:A07.231.114.056, MP:0000272, Wikipedia:Aorta] subset: efo_slim subset: grouping_class subset: human_reference_atlas subset: pheno_slim subset: uberon_slim synonym: "arteria maxima" RELATED OMO:0003011 [Wikipedia:Aorta] synonym: "dorsal aorta" NARROW SENSU [Wikipedia:Aorta#In_other_animals, ZFA:0000014] synonym: "trunk of aortic tree" EXACT [] synonym: "trunk of systemic arterial tree" EXACT [] xref: AAO:0010213 xref: BTO:0000135 xref: CALOHA:TS-0046 xref: EFO:0000265 xref: EMAPA:18601 xref: EV:0100027 xref: FMA:3734 xref: GAID:469 xref: galen:Aorta xref: MA:0000062 xref: MAT:0000035 xref: MESH:D001011 xref: MIAA:0000035 xref: NCIT:C12669 xref: SCTID:181298001 xref: UMLS:C0003483 {source="ncithesaurus:Aorta"} xref: VHOG:0001523 xref: Wikipedia:Aorta xref: XAO:0003010 is_a: UBERON:0003509 {source="MA"} ! arterial blood vessel is_a: UBERON:0003519 ! thoracic cavity blood vessel is_a: UBERON:0013768 ! great vessel of heart relationship: BFO:0000050 UBERON:0010191 {source="EHDAA2"} ! part of aortic system relationship: RO:0002170 UBERON:0002084 ! connected to heart left ventricle property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/blood-vasculature-female/v1.3/assets/3d-vh-f-blood-vasculature.glb" xsd:anyURI property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/blood-vasculature-male/v1.3/assets/3d-vh-m-blood-vasculature.glb" xsd:anyURI property_value: foaf:depiction "https://upload.wikimedia.org/wikipedia/commons/9/91/Aorta_scheme.jpg" xsd:anyURI property_value: IAO:0000116 "This class is currently a mixed bag, encompassing (1) the entirety of the mammalian aorta together with (2) the developmental and phylogenetic homologs of its segments: the ventral aorta and dorsal aortae." xsd:string {source="WP"} property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "aorta" xsd:string [Term] id: UBERON:0000948 name: heart def: "A myogenic muscular circulatory organ found in the vertebrate cardiovascular system composed of chambers of cardiac muscle. It is the primary circulatory organ." [http://orcid.org/0000-0002-6601-2165, Wikipedia:Heart] comment: Taxon notes:" the ascidian tube-like heart lacks chambers....The ascidian heart is formed after metamorphosis as a simple tube-like structure with a single-layered myoepithelium that is continuous with a single-layered pericar- dial wall. It lacks chambers and endocardium.... The innovation of the chambered heart was a key event in vertebrate evolution, because the chambered heart generates one-way blood flow with high pressure, a critical requirement for the efficient blood supply of large-body vertebrates... all extant vertebrates have hearts with two or more chambers (Moorman and Christoffels 2003)" DOI:10.1101/gad.1485706 subset: efo_slim subset: human_reference_atlas subset: major_organ subset: organ_slim subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "branchial heart" NARROW SENSU [] synonym: "cardium" RELATED [EMAPA:16105] synonym: "chambered heart" EXACT [https://orcid.org/0000-0002-6601-2165] synonym: "vertebrate heart" EXACT [] xref: AAO:0010210 xref: BILA:0000020 xref: BTO:0000562 xref: CALOHA:TS-0445 xref: EFO:0000815 xref: EHDAA2:0000738 xref: EHDAA:420 xref: EMAPA:16105 xref: EV:0100018 xref: FMA:7088 xref: GAID:174 xref: galen:Heart xref: MA:0000072 xref: MAT:0000036 xref: MESH:D006321 xref: MIAA:0000036 xref: NCIT:C12727 xref: SCTID:302509004 xref: TAO:0000114 xref: UMLS:C0018787 {source="ncithesaurus:Heart"} xref: VHOG:0000276 xref: Wikipedia:Heart xref: XAO:0000064 xref: ZFA:0000114 is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0005181 ! thoracic segment organ is_a: UBERON:0007100 ! primary circulatory organ is_a: UBERON:0010314 ! structure with developmental contribution from neural crest intersection_of: UBERON:0007100 ! primary circulatory organ intersection_of: BFO:0000051 UBERON:0004151 ! has part cardiac chamber relationship: BFO:0000050 UBERON:0015410 {source="MA"} ! part of heart plus pericardium relationship: BFO:0000051 UBERON:0004151 ! has part cardiac chamber relationship: RO:0002202 UBERON:0004141 ! develops from heart tube relationship: RO:0002433 UBERON:0004535 ! contributes to morphology of cardiovascular system property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/heart-female/v1.3/assets/3d-vh-f-heart.glb" xsd:anyURI property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/heart-male/v1.3/assets/3d-vh-m-heart.glb" xsd:anyURI property_value: RO:0002161 NCBITaxon:6239 property_value: RO:0002161 NCBITaxon:7227 property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "heart" xsd:string [Term] id: UBERON:0000949 name: endocrine system def: "Anatomical system that consists of the glands and parts of glands that produce endocrine secretions and help to integrate and control bodily metabolic activity." [NLM:endocrine+system, Wikipedia:Endocrine_system] subset: efo_slim subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "endocrine glandular system" EXACT [EHDAA2:0002224] synonym: "endocrine system" EXACT [] synonym: "systema endocrinum" EXACT [] xref: AAO:0010279 xref: CALOHA:TS-1301 xref: EFO:0002969 xref: EHDAA2:0002224 xref: EMAPA:35306 xref: EV:0100128 xref: FBbt:00005068 {sssom:mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"} xref: FMA:9668 xref: GAID:439 xref: MA:0000012 xref: MESH:D004703 xref: NCIT:C12705 xref: SCTID:278876000 xref: TAO:0001158 xref: UMLS:C0014136 {source="ncithesaurus:Endocrine_System"} xref: VHOG:0000098 xref: Wikipedia:Endocrine_system xref: XAO:0000158 xref: ZFA:0001158 is_a: BFO:0000004 is_a: UBERON:0015204 ! glandular system disjoint_from: UBERON:0000990 ! reproductive system disjoint_from: UBERON:0001004 ! respiratory system disjoint_from: UBERON:0001007 ! digestive system disjoint_from: UBERON:0001009 ! circulatory system disjoint_from: UBERON:0001016 ! nervous system disjoint_from: UBERON:0001033 ! gustatory system disjoint_from: UBERON:0001434 ! skeletal system disjoint_from: UBERON:0002204 ! musculoskeletal system disjoint_from: UBERON:0002294 ! biliary system disjoint_from: UBERON:0002330 ! exocrine system disjoint_from: UBERON:0002390 ! hematopoietic system disjoint_from: UBERON:0002405 ! immune system disjoint_from: UBERON:0002416 ! integumental system disjoint_from: UBERON:0002423 ! hepatobiliary system disjoint_from: UBERON:0004456 ! entire sense organ system disjoint_from: UBERON:8450002 ! excretory system relationship: RO:0002473 UBERON:0002368 ! composed primarily of endocrine gland relationship: RO:0002492 UBERON:0000066 ! existence ends during fully formed stage property_value: skos:prefLabel "endocrine system" xsd:string [Term] id: UBERON:0000951 name: rotator muscle of the vertebral column def: "Any of a number of short transversospinal muscles chiefly developed in cervical, lumbar, and thoracic regions, arising from the transverse process of one vertebra and inserted into the root of the spinous process of the next two or three vertebrae above, with nerve supply from the dorsal branches of the spinal nerve, and whose actions rotate the vertebral column." [http://medical-dictionary.thefreedictionary.com/rotator+muscle] synonym: "rotator muscle" BROAD [FMA:23081] xref: FMA:23081 xref: SCTID:244872002 is_a: UBERON:0001630 ! muscle organ is_a: UBERON:0005174 ! dorsal region element intersection_of: UBERON:0001630 ! muscle organ intersection_of: BFO:0000050 UBERON:0001137 ! part of dorsum intersection_of: RO:0002372 UBERON:0001077 ! has muscle origin transverse process of vertebra intersection_of: RO:0002373 UBERON:0001076 ! has muscle insertion neural spine relationship: RO:0002372 UBERON:0001077 ! has muscle origin transverse process of vertebra relationship: RO:0002373 UBERON:0001076 ! has muscle insertion neural spine [Term] id: UBERON:0000955 name: brain def: "The brain is the center of the nervous system in all vertebrate, and most invertebrate, animals. Some primitive animals such as jellyfish and starfish have a decentralized nervous system without a brain, while sponges lack any nervous system at all. In vertebrates, the brain is located in the head, protected by the skull and close to the primary sensory apparatus of vision, hearing, balance, taste, and smell[WP]." [https://github.com/obophenotype/uberon/issues/300, Wikipedia:Brain] subset: cumbo subset: efo_slim subset: human_reference_atlas subset: major_organ subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "encephalon" RELATED [BTO:0000142] synonym: "suprasegmental levels of nervous system" RELATED [NeuroNames:21] synonym: "suprasegmental structures" RELATED [NeuroNames:21] synonym: "synganglion" RELATED [] synonym: "the brain" RELATED [NeuroNames:21] xref: AAO:0010478 xref: ABA:Brain xref: BAMS:Br xref: BAMS:Brain xref: BILA:0000135 xref: BIRNLEX:796 xref: BTO:0000142 xref: CALOHA:TS-0095 xref: DHBA:10155 xref: EFO:0000302 xref: EHDAA2:0000183 xref: EHDAA:2641 xref: EHDAA:6485 xref: EMAPA:16894 xref: EV:0100164 xref: FBbt:00005095 {sssom:mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"} xref: FMA:50801 xref: GAID:571 xref: galen:Brain xref: HBA:4005 xref: MA:0000168 xref: MAT:0000098 xref: MBA:8 xref: MBA:997 xref: MESH:D001921 xref: MIAA:0000098 xref: NCIT:C12439 xref: neuronames:21 {source="BIRNLEX:796"} xref: PBA:3999 xref: SCTID:258335003 xref: TAO:0000008 xref: UMLS:C0006104 {source="ncithesaurus:Brain", source="BIRNLEX:796"} xref: UMLS:C1269537 {source="BIRNLEX:796"} xref: VHOG:0000157 xref: Wikipedia:Brain xref: XAO:0000010 xref: ZFA:0000008 is_a: UBERON:0000062 {source="GO"} ! organ is_a: UBERON:0004121 ! ectoderm-derived structure relationship: BFO:0000050 UBERON:0001017 {source="FMA"} ! part of central nervous system relationship: BSPO:0000123 UBERON:0000468 ! multicellular organism relationship: RO:0002433 UBERON:0001016 ! contributes to morphology of nervous system relationship: RO:0002473 CL:0002319 ! composed primarily of neural cell relationship: RO:0002492 UBERON:0000066 ! existence ends during fully formed stage relationship: RO:0002495 UBERON:0006238 {source="Bgee:AN"} ! immediate transformation of future brain property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/brain-female/v1.4/assets/3d-allen-f-brain.glb" xsd:anyURI property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/brain-male/v1.4/assets/3d-allen-m-brain.glb" xsd:anyURI property_value: IAO:0000116 "requires review for applicability to invertebrate structures, e.g. synganglion" xsd:string property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "brain" xsd:string property_value: terms:contributor https://orcid.org/0000-0002-6601-2165 [Term] id: UBERON:0000956 name: cerebral cortex def: "The thin layer of gray matter on the surface of the cerebral hemisphere that develops from the telencephalon. It consists of the neocortex (6 layered cortex or isocortex), the hippocampal formation and the olfactory cortex." [BIRNLEX:1494] subset: efo_slim subset: human_reference_atlas subset: pheno_slim subset: uberon_slim synonym: "brain cortex" RELATED [BTO:0000233] synonym: "cortex cerebralis" RELATED OMO:0003011 [NeuroNames:39] synonym: "cortex cerebri" RELATED OMO:0003011 [Wikipedia:Cerebral_cortex] synonym: "cortex of cerebral hemisphere" EXACT [BTO:0000233, FMA:61830] synonym: "cortical plate (areas)" RELATED [NeuroNames:39] synonym: "cortical plate (CTXpl)" RELATED [NeuroNames:39] synonym: "pallium of the brain" RELATED [BTO:0000233] xref: BAMS:C xref: BAMS:Cerebral_cortex xref: BAMS:CTX xref: BAMS:Cx xref: BIRNLEX:1494 xref: BM:Tel-Cx xref: BTO:0000233 xref: CALOHA:TS-0091 xref: DHBA:10159 xref: EFO:0000328 xref: EHDAA2:0000234 xref: EHDAA:5464 xref: EMAPA:17544 xref: EV:0100166 xref: FMA:61830 xref: GAID:629 xref: HBA:4008 xref: MA:0000185 xref: MAT:0000108 xref: MBA:688 xref: MESH:D002540 xref: MIAA:0000108 xref: NCIT:C12443 xref: neuronames:39 {source="BIRNLEX:1494"} xref: PBA:128011354 xref: SCTID:362880003 xref: UMLS:C0007776 {source="ncithesaurus:Cortex", source="BIRNLEX:1494"} xref: VHOG:0000722 xref: Wikipedia:Cerebral_cortex is_a: BFO:0000002 is_a: UBERON:0011215 ! central nervous system cell part cluster is_a: UBERON:0016548 {source="FMA"} ! central nervous system gray matter layer relationship: BFO:0000050 UBERON:0000203 {source="GO", source="ISBN:0471888893"} ! part of pallium relationship: BFO:0000050 UBERON:0005401 {source="FMA", source="MA"} ! part of cerebral hemisphere gray matter relationship: RO:0002216 GO:0007613 {source="Wikipedia"} ! capable of part of memory relationship: RO:0002254 UBERON:0004035 ! has developmental contribution from cortical subplate relationship: RO:0002254 UBERON:0005343 ! has developmental contribution from cortical plate relationship: RO:0002433 UBERON:0001893 ! contributes to morphology of telencephalon property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/7/7b/Cerebral_Cortex_location.jpg" xsd:anyURI property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/9/9a/Brainmaps-macaque-hippocampus.jpg" xsd:anyURI property_value: RO:0002175 NCBITaxon:117569 property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "cerebral cortex" xsd:string [Term] id: UBERON:0000957 name: lamina def: "Any thin layer or plate." [Wikipedia:Lamina_of_the_vertebral_arch] subset: non_informative subset: uberon_slim subset: upper_level synonym: "laminar tissue" EXACT [] xref: Wikipedia:Lamina_of_the_vertebral_arch is_a: UBERON:0000479 ! tissue intersection_of: UBERON:0000479 ! tissue intersection_of: RO:0000086 PATO:0002124 ! has quality laminar relationship: RO:0000086 PATO:0002124 ! has quality laminar property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/8/80/Laminaarcusvertebrae.png" xsd:anyURI property_value: IAO:0000116 "TODO - merge with cell layer?" xsd:string property_value: skos:prefLabel "lamina" xsd:string [Term] id: UBERON:0000958 name: medulla of organ def: "Middle part of an organ, surrounded by the cortex." [http://orcid.org/0000-0002-6601-2165] subset: upper_level synonym: "medulla" EXACT [FMA:61108] xref: FMA:61108 xref: galen:Medulla is_a: UBERON:0000471 ! compound organ component relationship: RO:0002162 NCBITaxon:6072 ! in taxon Eumetazoa relationship: RO:0002219 UBERON:0001851 ! surrounded by cortex [Term] id: UBERON:0000959 name: optic chiasma def: "A decussation of the diencephalon where the fibers of the optic nerve cross." [http://orcid.org/0000-0002-6601-2165, MGI:llw2, MP:0009770, Wikipedia:Optic_chiasm] subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "chiasma" RELATED OMO:0003011 [NeuroNames:459] synonym: "chiasma nervorum opticorum" RELATED OMO:0003011 [NeuroNames:459] synonym: "chiasma opticum" EXACT OMO:0003011 [Wikipedia:Optic_chiasm] synonym: "decussation of optic nerve fibers" EXACT [FMA:62045] synonym: "optic chiasm" EXACT [Wikipedia:Optic_chiasm] synonym: "optic chiasm (Rufus of Ephesus)" RELATED [NeuroNames:459] xref: AAO:0010622 xref: BAMS:DC xref: BAMS:OC xref: BAMS:och xref: BAMS:ox xref: BIRNLEX:1416 xref: BM:Tel-OCX xref: DHBA:10644 xref: DMBA:17783 xref: EHDAA2:0001302 xref: EHDAA:10227 xref: EMAPA:17603 xref: FMA:62045 xref: GAID:832 xref: HBA:9310 xref: MA:0001098 xref: MBA:117 xref: MESH:D009897 xref: NCIT:C90609 xref: neuronames:459 {source="BIRNLEX:1416"} xref: SCTID:244453006 xref: TAO:0000556 xref: UMLS:C0029126 {source="BIRNLEX:1416", source="ncithesaurus:Optic_Chiasm"} xref: VHOG:0000190 xref: Wikipedia:Optic_chiasm xref: XAO:0004071 xref: ZFA:0000556 is_a: UBERON:0007425 ! decussation of diencephalon intersection_of: UBERON:0007418 ! neural decussation intersection_of: BFO:0000050 UBERON:0001894 ! part of diencephalon intersection_of: extends_fibers_into UBERON:0000941 ! cranial nerve II intersection_of: extends_fibers_into UBERON:0001908 ! optic tract relationship: extends_fibers_into UBERON:0000941 ! cranial nerve II relationship: extends_fibers_into UBERON:0001908 ! optic tract property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/b/b3/1543%2CVisalius%27OpticChiasma.jpg" xsd:anyURI property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/brain-female/v1.4/assets/3d-allen-f-brain.glb" xsd:anyURI property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/brain-male/v1.4/assets/3d-allen-m-brain.glb" xsd:anyURI property_value: skos:prefLabel "optic chiasma" xsd:string [Term] id: UBERON:0000961 name: thoracic ganglion def: "The thoracic ganglia are paravertebral ganglia. The thoracic portion of the sympathetic trunk typically has 12 thoracic ganglia. Emerging from the ganglia are thoracic splancic nerves (the cardiopulmonary, the greater, lesser, and least splanchic nerves) that help provide sympathetic innervation to abdominal structures. Also, the ganglia of the thoracic sympathetic trunk have both white and gray rami communicantes. The white rami carry sympathetic fibers arising in the spinal cord into the sympathetic trunk. [WP,unvetted]." [Wikipedia:Thoracic_ganglion] subset: human_reference_atlas subset: uberon_slim synonym: "ganglion of thorax" EXACT [OBOL:automatic] synonym: "ganglion thoracicum splanchnicum" EXACT OMO:0003011 [FMA:6471, FMA:TA] synonym: "thoracic paravertebral ganglion" EXACT [MA:0001159] synonym: "thoracic splanchnic ganglion" EXACT [] synonym: "thoracic sympathetic ganglion" EXACT [] synonym: "thorax ganglion" EXACT [OBOL:automatic] xref: BTO:0001831 xref: EHDAA:4664 xref: EMAPA:17158 xref: FMA:6471 xref: MA:0001159 xref: NCIT:C52829 xref: RETIRED_EHDAA2:0002012 xref: SCTID:181102004 xref: UMLS:C0229010 {source="ncithesaurus:Thoracic_Ganglion"} xref: VHOG:0000515 xref: Wikipedia:Thoracic_ganglion is_a: UBERON:0001807 ! paravertebral ganglion intersection_of: UBERON:0001807 ! paravertebral ganglion intersection_of: BFO:0000050 UBERON:0004863 ! part of thoracic sympathetic nerve trunk relationship: BFO:0000050 UBERON:0004863 ! part of thoracic sympathetic nerve trunk relationship: extends_fibers_into UBERON:0018679 ! thoracic splanchnic nerve property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/3/3e/Gray849.png" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0000962 name: nerve of cervical vertebra def: "The cervical nerves are the spinal nerves from the cervical vertebrae. Although there are seven cervical vertebrae (C1-C7), there are eight cervical nerves (C1-C8). All nerves except C8 emerge above their corresponding vertebrae, while the C8 nerve emerges below the C7 vertebra. (In the other portions of the spine, the nerve emerges below the vertebra with the same name. Dorsal (posterior) distribution includes the greater occipital (C2) and third occipital (C3). Ventral (anterior) distribution includes the cervical plexus (C1-C4) and brachial plexus (C5-C8) [WP,unvetted]." [Wikipedia:Cervical_nerves] comment: Innervates: sternohyoid muscle, sternothyroid muscle, omohyoid muscle[WP] subset: human_reference_atlas subset: uberon_slim synonym: "cervical nerve" EXACT [FMA:5859] synonym: "cervical nerve tree" EXACT [] synonym: "cervical spinal nerve" EXACT [] synonym: "nervus cervicalis" EXACT OMO:0003011 [FMA:5859, FMA:TA] xref: BAMS:cern xref: FMA:5859 xref: NCIT:C32299 xref: neuronames:2351 xref: NLXANAT:20090207 xref: SCTID:360497008 xref: UMLS:C0228815 {source="ncithesaurus:Cervical_Nerve"} xref: Wikipedia:Cervical_nerves is_a: UBERON:0001780 ! spinal nerve intersection_of: UBERON:0001780 ! spinal nerve intersection_of: extends_fibers_into UBERON:0002726 ! cervical spinal cord relationship: extends_fibers_into UBERON:0002726 ! cervical spinal cord property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/e/e6/Gray795.png" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "nerve of cervical vertebra" xsd:string [Term] id: UBERON:0000963 name: head sensillum xref: FBbt:00004114 {sssom:mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"} xref: MAT:0000204 xref: MIAA:0000204 is_a: UBERON:0002536 ! arthropod sensillum intersection_of: UBERON:0002536 ! arthropod sensillum intersection_of: BFO:0000050 UBERON:0000033 ! part of head relationship: BFO:0000050 UBERON:0000033 ! part of head property_value: IAO:0000116 "this term should be ceded to the arthropod anatomy ontology" xsd:string [Term] id: UBERON:0000964 name: cornea def: "The transparent anterior portion of the fibrous coat of the eye that serves as the chief refractory structure." [ISBN:0-683-40008-8, MESH:A09.371.060.217, MP:0001312] subset: efo_slim subset: human_reference_atlas subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "cornea of camera-type eye" EXACT [GO:0061303] synonym: "corneas" RELATED OMO:0003004 [ZFA:0000640] synonym: "tunica cornea" RELATED [] xref: AAO:0010344 xref: BTO:0000286 xref: CALOHA:TS-0171 xref: EFO:0000377 xref: EHDAA2:0000316 xref: EHDAA:10199 xref: EMAPA:17161 xref: EV:0100341 xref: FMA:58238 xref: GAID:892 xref: MA:0000266 xref: MESH:D003315 xref: NCIT:C12342 xref: SCTID:181162001 xref: TAO:0000640 xref: UMLS:C0010031 {source="ncithesaurus:Cornea"} xref: VHOG:0000164 xref: Wikipedia:Cornea xref: XAO:0000180 xref: ZFA:0000640 is_a: UBERON:0010000 ! multicellular anatomical structure is_a: UBERON:0010313 ! neural crest-derived structure relationship: BFO:0000050 UBERON:0001801 {source="MA"} ! part of anterior segment of eyeball relationship: BFO:0000050 UBERON:0010409 {source="MA"} ! part of ocular surface region relationship: BFO:0000050 UBERON:0012430 {source="FMA-isa"} ! part of tunica fibrosa of eyeball relationship: BFO:0000051 UBERON:0001772 ! has part corneal epithelium relationship: BFO:0000051 UBERON:0004370 ! has part anterior limiting lamina of cornea relationship: RO:0000086 PATO:0000964 ! has quality transparent relationship: RO:0002150 UBERON:0001773 ! continuous with sclera relationship: RO:0002202 UBERON:0004348 {evidence="definitional"} ! develops from optic eminence relationship: RO:0002202 UBERON:0005427 ! develops from corneal primordium relationship: RO:0002256 UBERON:0005426 ! developmentally induced by lens vesicle relationship: RO:0002433 UBERON:0001801 ! contributes to morphology of anterior segment of eyeball property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/1/1e/Schematic_diagram_of_the_human_eye_en.svg" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "cornea" xsd:string [Term] id: UBERON:0000965 name: lens of camera-type eye def: "A transparent and refractive lens located posterior to the iris. The lens of camera-type eye refracts light to be focused on the retina." [http://orcid.org/0000-0002-6601-2165, Wikipedia:Lens_(anatomy)] comment: The lens is avascular and nourished by diffusion from the aqueous and vitreous humors. subset: human_reference_atlas subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "camera-type eye lens" EXACT [GO:0002088] synonym: "crystalline lens" RELATED [BTO:0000723, PMID:36055924] synonym: "eye lens" EXACT SENSU [] synonym: "lens" EXACT SENSU [] synonym: "lens crystallina" EXACT [Wikipedia:Lens_(anatomy)] synonym: "lenses" RELATED OMO:0003004 [ZFA:0000035] synonym: "ocular lens" RELATED [BTO:0000723] xref: AAO:0010348 xref: BTO:0000723 xref: CALOHA:TS-0545 xref: EHDAA:9057 xref: EMAPA:17838 xref: EV:0100343 xref: FMA:58241 xref: MA:0000275 xref: MAT:0000141 xref: MESH:D007908 xref: MIAA:0000141 xref: NCIT:C12743 xref: RETIRED_EHDAA2:0000975 xref: SCTID:181169005 xref: TAO:0000035 xref: UMLS:C0023317 {source="ncithesaurus:Crystalline_Lens"} xref: VHOG:0000169 xref: Wikipedia:Lens_(anatomy) xref: XAO:0000008 xref: ZFA:0000035 is_a: BFO:0000002 is_a: UBERON:0005389 ! transparent eye structure relationship: BFO:0000050 UBERON:0001801 ! part of anterior segment of eyeball relationship: RO:0002202 UBERON:0005426 ! develops from lens vesicle relationship: RO:0002256 UBERON:0003902 ! developmentally induced by retinal neural layer relationship: RO:0002433 UBERON:0001801 ! contributes to morphology of anterior segment of eyeball property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "lens of camera-type eye" xsd:string [Term] id: UBERON:0000966 name: retina def: "The retina is the innermost layer or coating at the back of the eyeball, which is sensitive to light and in which the optic nerve terminates." [Wikipedia:Retina, ZFIN:curator] comment: Currently this class encompasses only verteberate AOs but could in theory also include cephalopod - we may want to make a more specific class for vertebrate retina. note that this class excludes ommatidial retinas, as the retina must be part of an eyeball. Use the parent class photoreceptor array / light-sensitive tissue for arthropods subset: efo_slim subset: human_reference_atlas subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "inner layer of eyeball" EXACT [] synonym: "Netzhaut" RELATED [BTO:0001175] synonym: "retina of camera-type eye" EXACT [GO:0060041] synonym: "retinas" RELATED OMO:0003004 [ZFA:0000152] synonym: "tunica interna of eyeball" EXACT [] xref: AAO:0010352 xref: BAMS:R xref: BIRNLEX:1153 xref: BTO:0001175 xref: CALOHA:TS-0865 xref: EFO:0000832 xref: EHDAA2:0001627 xref: EHDAA:4757 xref: EMAPA:17168 xref: EV:0100348 xref: FMA:58301 xref: GAID:755 xref: MA:0000276 xref: MAT:0000142 xref: MBA:304325711 xref: MESH:D012160 xref: MIAA:0000142 xref: NCIT:C12343 xref: neuronames:1862 xref: NIFSTD_RETIRED:birnlex_1156 xref: SCTID:181171005 xref: TAO:0000152 xref: UMLS:C0035298 {source="BIRNLEX:1153", source="ncithesaurus:Retina"} xref: UMLS:C1278894 {source="BIRNLEX:1153"} xref: VHOG:0000229 xref: Wikipedia:Retina xref: XAO:0000009 xref: ZFA:0000152 is_a: UBERON:0004121 ! ectoderm-derived structure is_a: UBERON:0005388 ! photoreceptor array relationship: BFO:0000050 UBERON:0001802 ! part of posterior segment of eyeball relationship: BFO:0000050 UBERON:0019207 ! part of chorioretinal region relationship: BFO:0000051 CL:0000573 {source="FMA"} ! has part retinal cone cell relationship: BFO:0000051 CL:0000604 {source="FMA"} ! has part retinal rod cell relationship: BFO:0000051 CL:0000740 {source="FMA"} ! has part retinal ganglion cell relationship: RO:0002202 UBERON:0003072 {source="EHDAA2"} ! develops from optic cup property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/e/ed/Human_eye_cross-sectional_view_grayscale.png" xsd:anyURI property_value: RO:0002161 NCBITaxon:6656 property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "retina" xsd:string [Term] id: UBERON:0000970 name: eye def: "An organ that detects light." [https://orcid.org/0000-0002-6601-2165] subset: efo_slim subset: functional_classification subset: human_reference_atlas subset: major_organ subset: organ_slim subset: uberon_slim synonym: "light-detecting organ" RELATED [] synonym: "visual apparatus" RELATED [EV:0100336] xref: BILA:0000017 xref: BTO:0000439 xref: CALOHA:TS-0309 xref: EFO:0000827 xref: EV:0100336 xref: FBbt:00005162 {sssom:mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"} xref: GAID:69 xref: MAT:0000140 xref: MESH:D005123 xref: MIAA:0000140 xref: Wikipedia:Eye is_a: UBERON:0000020 ! sense organ relationship: BFO:0000050 UBERON:0002104 ! part of visual system relationship: BFO:0000051 CL:0000149 {source="PMID:21062451"} ! has part visual pigment cell relationship: BFO:0000051 CL:0000210 {source="PMID:21062451"} ! has part photoreceptor cell relationship: RO:0002215 GO:0009584 ! capable of detection of visible light property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "eye" xsd:string [Term] id: UBERON:0000971 name: ommatidium def: "The smallest morphological and functional unit of the compound eye that consists of a usually limited and often constant number of rhabdomeric photoreceptor cells, cornea-secreting epithelial cells, and interommatidial pigment cells, and may additionally contain crystalline cone cells." [PMID:21062451] subset: uberon_slim synonym: "omatidia" RELATED OMO:0003004 [] synonym: "omatidium" EXACT [] xref: BTO:0001922 xref: FBbt:00004510 {sssom:mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"} xref: HAO:0000666 xref: MAT:0000143 xref: MIAA:0000143 xref: Wikipedia:Ommatidium is_a: UBERON:0000970 {source="PMID:21062451"} ! eye is_a: UBERON:0002536 ! arthropod sensillum relationship: BFO:0000050 UBERON:0000018 ! part of compound eye [Term] id: UBERON:0000974 name: neck def: "An organism subdivision that extends from the head to the pectoral girdle, encompassing the cervical vertebral column." [http://orcid.org/0000-0002-6601-2165] subset: efo_slim subset: pheno_slim subset: uberon_slim synonym: "collum" RELATED OMO:0003011 [Wikipedia:Neck] synonym: "neck (volume)" RELATED [FMA:7155] xref: AEO:0000108 xref: BTO:0000420 xref: CALOHA:TS-2045 xref: EFO:0000967 xref: EHDAA2:0003108 xref: EMAPA:35587 xref: FMA:7155 xref: GAID:86 xref: galen:Neck xref: MA:0000024 xref: MAT:0000297 xref: MESH:D009333 xref: MIAA:0000297 xref: NCIT:C13063 xref: SCTID:302550007 xref: UMLS:C0027530 {source="ncithesaurus:Neck"} xref: Wikipedia:Neck is_a: UBERON:0000475 ! organism subdivision relationship: anteriorly_connected_to UBERON:0000033 ! head relationship: BFO:0000050 UBERON:0000153 ! part of anterior region of body relationship: posteriorly_connected_to UBERON:0002100 ! trunk property_value: foaf:depiction "https://upload.wikimedia.org/wikipedia/commons/9/99/Female_neck.jpg" xsd:anyURI property_value: skos:prefLabel "neck" xsd:string [Term] id: UBERON:0000975 name: sternum def: "A midventral endochondral skeletal element which represents the origin site of the pectoral muscles[PHENOSCAPE:ad]." [https://github.com/obophenotype/uberon/issues/67, PHENOSCAPE:ad] subset: human_reference_atlas subset: pheno_slim subset: uberon_slim synonym: "breastbone" RELATED [BTO:0001302] synonym: "vertebrate sternum" EXACT [] xref: AAO:0000765 xref: BTO:0001302 xref: CALOHA:TS-0972 xref: EHDAA2:0001914 xref: EHDAA:9561 xref: EMAPA:18344 xref: FMA:7485 xref: GAID:246 xref: galen:Sternum xref: MA:0001331 xref: MESH:D013249 xref: NCIT:C12793 xref: SCTID:302522007 xref: UMLS:C0038293 {source="ncithesaurus:Sternum"} xref: VHOG:0000856 xref: Wikipedia:Sternum is_a: UBERON:0005181 ! thoracic segment organ is_a: UBERON:0010363 {source="ISBN:0073040584"} ! endochondral element relationship: BFO:0000050 UBERON:0003252 {source="FMA"} ! part of thoracic rib cage relationship: RO:0002162 NCBITaxon:32523 {source="ISBN:0073040584"} ! in taxon Tetrapoda relationship: RO:0002170 UBERON:0002228 ! connected to rib relationship: RO:0002170 UBERON:0007831 ! connected to pectoral girdle skeleton relationship: RO:0002433 UBERON:0003252 ! contributes to morphology of thoracic rib cage property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/1/12/Illu_thoracic_cage.jpg" xsd:anyURI property_value: IAO:0000116 "in EMAPA and EHDAA2 this is part of the skeleton of pectoral girdle; the classic def of pectoral girdle (see WP) excludes the rib cage and sternum" xsd:string property_value: RO:0002161 NCBITaxon:8570 {source="Wikipedia"} property_value: RO:0002175 NCBITaxon:9606 property_value: terms:contributor https://orcid.org/0000-0001-7972-3866 property_value: terms:contributor https://orcid.org/0000-0002-6601-2165 [Term] id: UBERON:0000976 name: humerus def: "Paired endochondral long bone that extends between the pectoral girdle and the skeletal parts of the forelimb. [PHENOSCAPE:mah]." [AAO:0000679, https://github.com/obophenotype/uberon/issues/106, PHENOSCAPE:mah] subset: efo_slim subset: human_reference_atlas subset: pheno_slim subset: uberon_slim synonym: "humeri" EXACT OMO:0003004 [PHENOSCAPE:ad] synonym: "humerus bone" EXACT [] synonym: "mesomere 1 of pectoral appendage" RELATED HOMOLOGY [ISBN:0226313409] synonym: "proximal metapterygial mesomere of pectoral appendage" RELATED HOMOLOGY [ISBN:0226313409] synonym: "proximal metapterygial mesomere of pectoral fin" RELATED HOMOLOGY [ISBN:0226313409] xref: AAO:0000679 xref: CALOHA:TS-2202 xref: EFO:0001398 xref: EMAPA:19106 xref: FMA:13303 xref: GAID:183 xref: galen:Humerus xref: MA:0001356 xref: MESH:D006811 xref: NCIT:C12731 xref: SCTID:181923006 xref: UMLS:C0020164 {source="ncithesaurus:Humerus"} xref: VHOG:0001158 xref: Wikipedia:Humerus xref: XAO:0003210 is_a: UBERON:0003461 ! shoulder bone is_a: UBERON:0003607 ! forelimb long bone is_a: UBERON:0004250 ! upper arm bone is_a: UBERON:0015053 ! humerus endochondral element intersection_of: UBERON:0015053 ! humerus endochondral element intersection_of: RO:0002473 UBERON:0002481 ! composed primarily of bone tissue relationship: proximally_connected_to UBERON:0007831 ! pectoral girdle skeleton relationship: RO:0002131 UBERON:0001470 ! overlaps glenohumeral joint relationship: RO:0002202 UBERON:0006245 {evidence="definitional"} ! develops from humerus cartilage element property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/6/67/Illu_upper_extremity.jpg" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 property_value: terms:contributor https://orcid.org/0000-0001-9114-8737 property_value: terms:contributor https://orcid.org/0000-0002-6601-2165 [Term] id: UBERON:0000977 name: pleura def: "The invaginated serous membrane that surrounds the lungs (the visceral portion) and lines the walls of the pleural cavity (parietal portion)." [https://github.com/obophenotype/uberon/issues/1231, ISBN:0-683-40008-8, MP:0010820, UBERON:cjm, Wikipedia:Pulmonary_pleurae] subset: efo_slim subset: pheno_slim subset: uberon_slim synonym: "pleura" RELATED [] synonym: "pleural tissue" RELATED [BTO:0001791, NCIT:C12469] synonym: "wall of pleural sac" EXACT [] xref: BTO:0001791 xref: CALOHA:TS-2081 xref: EFO:0001980 xref: EV:0100044 xref: FMA:9583 xref: GAID:360 xref: MA:0000433 xref: MESH:D010994 xref: NCIT:C12469 xref: SCTID:181609007 xref: UMLS:C0032225 {source="ncithesaurus:Pleural_Tissue"} xref: VHOG:0000394 xref: Wikipedia:Pleura is_a: UBERON:0000042 ! serous membrane intersection_of: UBERON:0000042 ! serous membrane intersection_of: BFO:0000050 UBERON:0009778 ! part of pleural sac intersection_of: BFO:0000051 UBERON:0002400 ! has part parietal pleura intersection_of: BFO:0000051 UBERON:0002401 ! has part visceral pleura relationship: BFO:0000050 UBERON:0009778 {source="https://github.com/obophenotype/uberon/issues/86"} ! part of pleural sac relationship: BFO:0000051 UBERON:0002400 ! has part parietal pleura relationship: BFO:0000051 UBERON:0002401 ! has part visceral pleura relationship: RO:0000086 PATO:0001748 ! has quality invaginated relationship: RO:0002202 UBERON:0003081 ! develops from lateral plate mesoderm relationship: RO:0002433 UBERON:0001004 ! contributes to morphology of respiratory system property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/a/ab/Gray965.png" xsd:anyURI property_value: RO:0002175 NCBITaxon:8782 {source="ISBN:978-0030223693", source="https://orcid.org/0000-0003-3308-6245"} property_value: skos:prefLabel "pleura" xsd:string [Term] id: UBERON:0000978 name: leg def: "The portion of the hindlimb that contains both the stylopod and zeugopod." [Wikipedia:Leg#Limb] comment: we use the less open to misinterpretation 'hindlimb zeugopod'. Editor note: currently declared as overlapping foot, as AOs disagree over whether some ankle parts are in the leg or foot subset: efo_slim subset: human_reference_atlas subset: pheno_slim subset: uberon_slim synonym: "lower extremity" RELATED [MESH:A01.378.610] synonym: "tetrapod leg" EXACT [] xref: BTO:0000721 xref: CALOHA:TS-2206 xref: EFO:0001411 xref: EHDAA2:0000972 xref: EHDAA:5151 xref: EHDAA:6176 xref: EHDAA:8289 xref: EMAPA:17489 xref: GAID:49 xref: MA:0000047 xref: MESH:D035002 xref: VHOG:0000345 xref: Wikipedia:Leg#Limb is_a: UBERON:0006058 ! multi-limb segment region is_a: UBERON:0008784 ! lower limb segment relationship: distally_connected_to UBERON:0002387 ! pes relationship: proximally_connected_to UBERON:0001464 ! hip property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0000979 name: tibia def: "The major preaxial endochondral bone in the posterior zeugopod[Phenoscape]." [PHENOSCAPE:mah] subset: efo_slim subset: human_reference_atlas subset: pheno_slim subset: uberon_slim synonym: "shankbone" EXACT [Wikipedia:Tibia] synonym: "shinbone" EXACT [Wikipedia:Tibia] xref: AAO:0000890 xref: BTO:0001252 xref: CALOHA:TS-1048 xref: EFO:0003054 xref: EMAPA:19142 xref: FMA:24476 xref: GAID:204 xref: galen:Tibia xref: MA:0001361 xref: MESH:D013977 xref: NCIT:C12800 xref: SCTID:182061009 xref: UMLS:C0040184 {source="ncithesaurus:Tibia"} xref: Wikipedia:Tibia is_a: UBERON:0003608 ! hindlimb long bone is_a: UBERON:0004251 ! hindlimb zeugopod bone is_a: UBERON:0015004 ! tibia endochondral element intersection_of: UBERON:0015004 ! tibia endochondral element intersection_of: RO:0002473 UBERON:0002481 ! composed primarily of bone tissue relationship: BSPO:0001113 UBERON:0010720 ! hindlimb zeugopod skeleton relationship: RO:0002202 UBERON:0010849 ! develops from tibia cartilage element property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/2/2a/Gray260.png" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0000981 name: femur def: "Endochondral longbone connecting the pelvic girdle with posterior zeugopodium skeleton.[VSAO, modified]." [VSAO:0000186, Wikipedia:Femur] subset: efo_slim subset: human_reference_atlas subset: pheno_slim subset: uberon_slim synonym: "femoral bone" RELATED [BTO:0001284] synonym: "mesomere 1 of pevlic appendage" RELATED HOMOLOGY [ISBN:0226313409] synonym: "os femorale" RELATED OMO:0003011 [BTO:0001284] synonym: "os femoris" RELATED OMO:0003011 [BTO:0001284] synonym: "os longissimum" RELATED OMO:0003011 [Wikipedia:Femur] synonym: "proximal metapterygial mesomere of pelvic appendage" RELATED HOMOLOGY [ISBN:0226313409] synonym: "proximal metapterygial mesomere of pelvic fin" RELATED HOMOLOGY [ISBN:0226313409] synonym: "thigh bone" EXACT [] xref: AAO:0000887 xref: AAO:0000889 xref: BTO:0001284 xref: CALOHA:TS-0322 xref: EFO:0001396 xref: EMAPA:19143 xref: FMA:9611 xref: GAID:199 xref: galen:Femur xref: MA:0001359 xref: MESH:D005269 xref: NCIT:C12717 xref: SCTID:182046008 xref: UMLS:C0015811 {source="ncithesaurus:Femur"} xref: VHOG:0001159 xref: VSAO:0000186 xref: Wikipedia:Femur xref: XAO:0003214 is_a: UBERON:0003608 ! hindlimb long bone is_a: UBERON:0003826 ! upper leg bone is_a: UBERON:0008202 {source="MA"} ! bone of hip region is_a: UBERON:0015052 ! femur endochondral element intersection_of: UBERON:0015052 ! femur endochondral element intersection_of: RO:0002473 UBERON:0002481 ! composed primarily of bone tissue relationship: proximally_connected_to UBERON:0007832 ! pelvic girdle skeleton relationship: RO:0002202 UBERON:0010129 {evidence="definitional"} ! develops from femur cartilage element property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/7/73/Gray252.png" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0000982 name: skeletal joint def: "Anatomical structure that consists of two or more adjacent skeletal structures, which may be interconnected by various types of tissue[VSAO]." [GO_REF:0000034, http://dx.plos.org/10.1371/journal.pone.0051070, VSAO:0000101, Wikipedia:Joint] subset: efo_slim subset: organ_slim subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "articular joint" RELATED [BTO:0001686] synonym: "articulation" BROAD [VSAO:0000101] synonym: "joint" BROAD [FMA:7490, VSAO:0000101] synonym: "joints" RELATED OMO:0003004 [ZFA:0001596] xref: AEO:0000182 xref: BTO:0001686 xref: CALOHA:TS-2023 xref: EFO:0000948 xref: EMAPA:35456 xref: FMA:7490 xref: GAID:102 xref: galen:Joint xref: MA:0000319 xref: MAT:0000188 xref: MESH:D007596 xref: MIAA:0000188 xref: NCIT:C13044 xref: RETIRED_EHDAA2:0003182 xref: SCTID:302536002 xref: TAO:0000367 xref: UMLS:C0022417 {source="ncithesaurus:Joint"} xref: VHOG:0001276 xref: VSAO:0000101 xref: Wikipedia:Joint xref: XAO:0000171 xref: ZFA:0001596 is_a: UBERON:0004905 ! articulation union_of: UBERON:0002217 ! synovial joint union_of: UBERON:0011134 ! nonsynovial joint disjoint_from: UBERON:0001474 ! bone element relationship: RO:0002176 UBERON:0004765 ! connects skeletal element relationship: RO:0002433 UBERON:0001434 ! contributes to morphology of skeletal system property_value: skos:prefLabel "skeletal joint" xsd:string [Term] id: UBERON:0000983 name: metatarsus region def: "A metapodium region that is part of a pes." [OBOL:automatic] subset: uberon_slim synonym: "hind metapodium" EXACT [AAO:0000221, http://en.wiktionary.org/wiki/metapodial, MA:th] synonym: "hindlimb cannon region" NARROW [http://orcid.org/0000-0002-6601-2165, NCBITaxon:9788] synonym: "hindlimb equine cannon region" NARROW [http://orcid.org/0000-0002-6601-2165, NCBITaxon:9788] synonym: "metatarsal part of foot" EXACT [FMA:24997] synonym: "metatarsal region" EXACT [FMA:24997] synonym: "metatarsus" RELATED [MA:0000049] synonym: "regio metatarsalis" EXACT OMO:0003011 [FMA:24997, FMA:TA] xref: CALOHA:TS-2221 xref: FMA:24997 xref: MA:0000049 xref: SCTID:280711000 xref: SCTID:370639003 is_a: UBERON:0008784 ! lower limb segment is_a: UBERON:0009877 ! metapodium region intersection_of: UBERON:0009877 ! metapodium region intersection_of: BFO:0000050 UBERON:0002387 ! part of pes relationship: BFO:0000050 UBERON:0012142 {source="PHENOSCAPE:ni"} ! part of pedal digitopodium region relationship: RO:0002551 UBERON:0010545 ! has skeleton metatarsus skeleton [Term] id: UBERON:0000985 name: axillary vein def: "Vein that drains the axilla." [http://orcid.org/0000-0002-6601-2165] subset: human_reference_atlas subset: uberon_slim synonym: "subcostal vein" RELATED [] synonym: "vena axillaris" EXACT OMO:0003011 [Wikipedia:Axillary_vein] xref: EMAPA:18758 xref: FMA:13329 xref: GAID:527 xref: galen:AxillaryVein xref: MA:0002084 xref: MESH:D001367 xref: NCIT:C32171 xref: SCTID:181389002 xref: UMLS:C0004456 {source="ncithesaurus:Axillary_Vein"} xref: Wikipedia:Axillary_vein is_a: UBERON:0001638 ! vein intersection_of: UBERON:0001638 ! vein intersection_of: RO:0020102 UBERON:0009472 ! vessel drains blood from axilla relationship: BFO:0000050 UBERON:0001467 ! part of shoulder relationship: RO:0002170 UBERON:0001587 ! connected to subclavian vein relationship: RO:0020102 UBERON:0009472 ! vessel drains blood from axilla property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/e/e9/Gray576.png" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0000988 name: pons def: "The part of the central nervous system lying between the medulla oblongata and the midbrain, ventral to the cerebellum." [VHOG:0001176] subset: efo_slim subset: human_reference_atlas subset: pheno_slim subset: uberon_slim synonym: "pons cerebri" RELATED OMO:0003011 [NeuroNames:547] synonym: "pons of Varolius" EXACT [] synonym: "pons Varolii" EXACT [ncithesaurus:Pons_Varolii] xref: BAMS:PONS xref: BAMS:Pons xref: BIRNLEX:733 xref: BM:Pons xref: BTO:0001101 xref: CALOHA:TS-0813 xref: DHBA:10661 xref: EFO:0001394 xref: EHDAA2:0004394 xref: EMAPA:17563 xref: EV:0100253 xref: FMA:67943 xref: GAID:578 xref: HBA:9131 xref: MA:0000204 xref: MAT:0000115 xref: MBA:771 xref: MESH:D011149 xref: MIAA:0000115 xref: NCIT:C12511 xref: neuronames:547 {source="BIRNLEX:733"} xref: SCTID:279103004 xref: UMLS:C0032639 {source="BIRNLEX:733", source="ncithesaurus:Pons_Varolii"} xref: UMLS:C1280999 {source="BIRNLEX:733"} xref: VHOG:0001176 xref: Wikipedia:Pons is_a: UBERON:0002616 ! regional part of brain relationship: BFO:0000050 UBERON:0001895 {source="neuronames"} ! part of metencephalon relationship: BFO:0000050 UBERON:0002298 ! part of brainstem relationship: RO:0002433 UBERON:0001895 ! contributes to morphology of metencephalon relationship: RO:0002433 UBERON:0002298 ! contributes to morphology of brainstem property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/3/36/Gray768.png" xsd:anyURI property_value: IAO:0000116 "The pons is not present in zebrafish. In this ontology we currently have some structures which are applicable to zebrafish appearing as parts of the pons. Currently we only include the weaker dubious_for_taxon relationship ubtil this is resolved" xsd:string property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "pons" xsd:string [Term] id: UBERON:0000989 name: penis def: "An intromittent organ in certain biologically male organisms. In placental mammals, this also serves as the organ of urination." [http://orcid.org/0000-0002-6601-2165, ISBN:0-683-40008-8, MP:0005187, Wikipedia:Penis] subset: efo_slim subset: organ_slim subset: pheno_slim subset: uberon_slim synonym: "penes" RELATED OMO:0003004 [] synonym: "phallus" RELATED [] xref: BTO:0000405 xref: CALOHA:TS-0758 xref: EFO:0000987 xref: EHDAA2:0001433 xref: EHDAA:9380 xref: EMAPA:18682 xref: EMAPA_RETIRED:18996 xref: EV:0100107 xref: FMA:9707 xref: GAID:389 xref: galen:Penis xref: MA:0000408 xref: MAT:0000186 xref: MESH:D010413 xref: MIAA:0000186 xref: NCIT:C12409 xref: SCTID:265793009 xref: UMLS:C0030851 {source="ncithesaurus:Penis"} xref: VHOG:0000727 xref: Wikipedia:Penis is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0008811 {source="Wikipedia"} ! intromittent organ relationship: RO:0002202 UBERON:0004876 {source="Wikipedia"} ! develops from urogenital fold relationship: RO:0002202 UBERON:0005876 {source="EHDAA2"} ! develops from undifferentiated genital tubercle property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/8/87/Labelled_flaccid_penis.jpg" xsd:anyURI [Term] id: UBERON:0000990 name: reproductive system def: "Anatomical system that has as its parts the organs concerned with reproduction." [Wikipedia:Reproductive_system] subset: efo_slim subset: functional_classification subset: human_reference_atlas subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "animal reproductive system" RELATED [BTO:0000081] synonym: "genital system" NARROW [] synonym: "genital tract" RELATED [] synonym: "genitalia" NARROW OMO:0003004 [] synonym: "Geschlechtsorgan" RELATED [BTO:0000081] synonym: "organa genitalia" RELATED [BTO:0000081] synonym: "reproductive tissue" RELATED [BTO:0000081] synonym: "reproductive tract" RELATED [] synonym: "systemata genitalia" RELATED OMO:0003011 [Wikipedia:Reproductive_system] xref: AAO:0010258 xref: BILA:0000103 xref: BTO:0000081 xref: CALOHA:TS-1318 xref: EFO:0000809 xref: EHDAA2:0001603 xref: EHDAA:5923 xref: EMAPA:17381 xref: EV:0100100 xref: FBbt:00004857 {sssom:mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"} xref: FMA:7160 xref: GAID:363 xref: HAO:0000374 xref: HAO:0000895 xref: MA:0000326 xref: MESH:D005835 {sssom:mapping_justification="https://w3id.org/semapv/vocab/LexicalMatching"} xref: MIAA:0000305 xref: NCIT:C12841 xref: SCTID:278875001 xref: TAO:0000632 xref: UMLS:C1261210 {source="ncithesaurus:Reproductive_System"} xref: VHOG:0000182 xref: WBbt:0005747 xref: Wikipedia:Reproductive_system xref: XAO:0000142 xref: ZFA:0000632 is_a: BFO:0000002 is_a: UBERON:0000467 ! anatomical system intersection_of: UBERON:0000467 ! anatomical system intersection_of: RO:0002216 GO:0022414 ! capable of part of reproductive process disjoint_from: UBERON:0001004 ! respiratory system disjoint_from: UBERON:0001007 ! digestive system disjoint_from: UBERON:0001009 ! circulatory system disjoint_from: UBERON:0001016 ! nervous system disjoint_from: UBERON:0001033 ! gustatory system disjoint_from: UBERON:0001434 ! skeletal system disjoint_from: UBERON:0002204 ! musculoskeletal system disjoint_from: UBERON:0002294 ! biliary system disjoint_from: UBERON:0002330 ! exocrine system disjoint_from: UBERON:0002390 ! hematopoietic system disjoint_from: UBERON:0002405 ! immune system disjoint_from: UBERON:0002416 ! integumental system disjoint_from: UBERON:0002423 ! hepatobiliary system disjoint_from: UBERON:0004456 ! entire sense organ system disjoint_from: UBERON:8450002 ! excretory system relationship: BFO:0000051 UBERON:0000991 ! has part gonad relationship: RO:0002216 GO:0022414 ! capable of part of reproductive process relationship: RO:0002492 UBERON:0000066 ! existence ends during fully formed stage property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/5/52/Penis.svg" xsd:anyURI property_value: IAO:0000116 "consider splitting genitalia from reproductive system" xsd:string property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "reproductive system" xsd:string property_value: terms:date "2022-06-10T18:22:34Z" xsd:dateTime [Term] id: UBERON:0000991 name: gonad def: "Reproductive organ that produces and releases eggs (ovary) or sperm (testis)." [ISBN:0140512888, Wikipedia:Gonad, ZFA:0000413, ZFIN:curator] subset: major_organ subset: organ_slim subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "gonada" EXACT [] synonym: "gonads" RELATED OMO:0003004 [ZFA:0000413] xref: AAO:0000213 xref: BILA:0000123 xref: BSA:0000079 xref: BTO:0000534 xref: EMAPA:17383 xref: FMA:18250 xref: GAID:368 xref: HAO:0000379 xref: MA:0002420 xref: MESH:D006066 xref: NCIT:C12725 xref: SCTID:304623008 xref: TAO:0000413 xref: UMLS:C0018067 {source="ncithesaurus:Gonad"} xref: VHOG:0000397 xref: WBbt:0005175 xref: Wikipedia:Gonad xref: XAO:0003146 xref: ZFA:0000413 is_a: BFO:0000002 is_a: UBERON:0003133 ! reproductive organ intersection_of: UBERON:0003133 ! reproductive organ intersection_of: BFO:0000051 CL:0000586 ! has part germ cell relationship: BFO:0000051 CL:0000586 ! has part germ cell relationship: BFO:0000067 GO:0007276 ! contains process gamete generation relationship: RO:0002202 UBERON:0005564 ! develops from gonad primordium property_value: skos:prefLabel "gonad" xsd:string [Term] id: UBERON:0000992 name: ovary def: "The gonad of a female organism which contains germ cells." [ISBN:0-683-40008-8, MP:0001126, Wikipedia:Ovary] subset: efo_slim subset: human_reference_atlas subset: organ_slim subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "animal ovary" EXACT [EFO:0000973] synonym: "female gonad" EXACT [] synonym: "female organism genitalia gonad" EXACT [OBOL:automatic] synonym: "female organism genitalia gonada" EXACT [OBOL:automatic] synonym: "female organism reproductive system gonad" EXACT [OBOL:automatic] synonym: "female organism reproductive system gonada" EXACT [OBOL:automatic] synonym: "female reproductive system gonad" EXACT [OBOL:automatic] synonym: "female reproductive system gonada" EXACT [OBOL:automatic] synonym: "genitalia of female organism gonad" EXACT [OBOL:automatic] synonym: "genitalia of female organism gonada" EXACT [OBOL:automatic] synonym: "gonad of female organism genitalia" EXACT [OBOL:automatic] synonym: "gonad of female organism reproductive system" EXACT [OBOL:automatic] synonym: "gonad of female reproductive system" EXACT [OBOL:automatic] synonym: "gonad of genitalia of female organism" EXACT [OBOL:automatic] synonym: "gonad of reproductive system of female organism" EXACT [OBOL:automatic] synonym: "gonada of female organism genitalia" EXACT [OBOL:automatic] synonym: "gonada of female organism reproductive system" EXACT [OBOL:automatic] synonym: "gonada of female reproductive system" EXACT [OBOL:automatic] synonym: "gonada of genitalia of female organism" EXACT [OBOL:automatic] synonym: "gonada of reproductive system of female organism" EXACT [OBOL:automatic] synonym: "ovaries" RELATED OMO:0003004 [] synonym: "ovarium" RELATED OMO:0003011 [Wikipedia:Ovary] synonym: "ovum-producing ovary" EXACT SENSU [GO:0061039] synonym: "reproductive system of female organism gonad" EXACT [OBOL:automatic] synonym: "reproductive system of female organism gonada" EXACT [OBOL:automatic] xref: AAO:0000371 xref: BILA:0000125 xref: BSA:0000080 xref: BTO:0000975 xref: CALOHA:TS-0730 xref: EFO:0000973 xref: EHDAA2:0001360 xref: EHDAA:8124 xref: EMAPA:17962 xref: EV:0100111 xref: FBbt:00004865 {sssom:mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"} xref: FMA:7209 xref: GAID:367 xref: MA:0000384 xref: MESH:D010053 xref: MIAA:0000125 xref: NCIT:C12404 xref: SCTID:181464007 xref: TAO:0000403 xref: UMLS:C0029939 {source="ncithesaurus:Ovary"} xref: VHOG:0000251 xref: Wikipedia:Ovary xref: XAO:0000258 xref: ZFA:0000403 is_a: UBERON:0000991 ! gonad is_a: UBERON:0003134 ! female reproductive organ intersection_of: UBERON:0000991 ! gonad intersection_of: BFO:0000050 UBERON:0000474 ! part of female reproductive system disjoint_from: UBERON:0009117 ! indifferent gonad relationship: RO:0002162 NCBITaxon:33208 ! in taxon Metazoa relationship: RO:0002202 UBERON:0009117 ! develops from indifferent gonad property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/d/d4/Gray589.png" xsd:anyURI property_value: foaf:depiction "https://upload.wikimedia.org/wikipedia/commons/c/cb/Female_anatomy.png" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "ovary" xsd:string [Term] id: UBERON:0000993 name: oviduct def: "A tube or collection of tubes in an animal from the ovaries to the outside of the body." [http://orcid.org/0000-0002-6601-2165] subset: efo_slim subset: uberon_slim subset: vertebrate_core synonym: "female reproductive tracts" RELATED [http://orcid.org/0000-0002-6601-2165] synonym: "ovarian duct" EXACT [http://orcid.org/0000-0002-6601-2165] synonym: "ovarian tube" EXACT [http://orcid.org/0000-0002-6601-2165] synonym: "oviducts" RELATED OMO:0003004 [ZFA:0000560] synonym: "tuba uterina" RELATED [BTO:0000980] synonym: "tuba uterinae" RELATED [BTO:0000980] synonym: "tubular parts of female reproductive system" RELATED [http://orcid.org/0000-0002-6601-2165] synonym: "uterine tube" NARROW [] xref: AAO:0010533 xref: BSA:0000083 xref: BTO:0000980 xref: EFO:0000974 xref: EMAPA:18984 xref: GAID:366 xref: MAT:0000126 xref: MESH:D010057 xref: MIAA:0000126 xref: NCIT:C77957 xref: TAO:0000560 xref: UMLS:C0029954 {source="ncithesaurus:Oviduct"} xref: VHOG:0001136 xref: Wikipedia:Oviduct xref: XAO:0003052 xref: ZFA:0000560 is_a: UBERON:0000025 ! tube is_a: UBERON:0005156 ! reproductive structure relationship: BFO:0000050 UBERON:0000474 ! part of female reproductive system relationship: RO:0002176 UBERON:0000992 ! connects ovary relationship: RO:0002176 UBERON:0013514 ! connects space surrounding organism [Term] id: UBERON:0000995 name: uterus def: "The female muscular organ of gestation in which the developing embryo or fetus is nourished until birth." [MGI:csmith, MP:0001120] subset: efo_slim subset: human_reference_atlas subset: organ_slim subset: pheno_slim subset: uberon_slim xref: BTO:0001424 xref: CALOHA:TS-1102 xref: EFO:0000975 xref: EMAPA:29915 xref: EV:0100113 xref: FMA:17558 xref: GAID:172 xref: galen:Uterus xref: MA:0000389 xref: MAT:0000127 xref: MESH:D014599 xref: MIAA:0000127 xref: NCIT:C12405 xref: SCTID:181452004 xref: UMLS:C0042149 {source="ncithesaurus:Uterus"} xref: VHOG:0001137 xref: Wikipedia:Uterus is_a: BFO:0000002 is_a: UBERON:0013515 {source="cjm"} ! subdivision of oviduct relationship: BFO:0000050 UBERON:0004175 ! part of internal genitalia relationship: RO:0002495 UBERON:0005795 ! immediate transformation of embryonic uterus property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/6/6a/Female_reproductive_system_lateral_nolabel.png" xsd:anyURI property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/uterus-female/v1.2/assets/3d-vh-f-uterus.glb" xsd:anyURI property_value: foaf:depiction "https://upload.wikimedia.org/wikipedia/commons/c/cb/Female_anatomy.png" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0000996 name: vagina def: "A fibromuscular tubular tract leading from the uterus to the exterior of the body in female placental mammals and marsupials, or to the cloaca in female birds, monotremes, and some reptiles[WP]." [http://orcid.org/0000-0002-6601-2165, Wikipedia:Vagina] subset: efo_slim subset: pheno_slim subset: uberon_slim synonym: "distal oviductal region" RELATED [] synonym: "distal portion of oviduct" RELATED [] synonym: "vaginae" RELATED OMO:0003004 [] xref: BTO:0000243 xref: CALOHA:TS-1103 xref: EFO:0000976 xref: EMAPA:18986 xref: EV:0100117 xref: FMA:19949 xref: GAID:381 xref: galen:Vagina xref: MA:0000394 xref: MAT:0000128 xref: MESH:D014621 xref: MIAA:0000128 xref: NCIT:C12407 xref: SCTID:181441005 xref: UMLS:C0042232 {source="ncithesaurus:Vagina"} xref: VHOG:0001138 xref: Wikipedia:Vagina is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0013515 {source="cjm"} ! subdivision of oviduct relationship: BFO:0000050 UBERON:0003975 {source="FMA"} ! part of internal female genitalia relationship: RO:0002202 UBERON:0000164 {source="Wikipedia"} ! develops from primitive urogenital sinus relationship: RO:0002433 UBERON:0003975 ! contributes to morphology of internal female genitalia property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/1/1b/Illu_repdt_female.jpg" xsd:anyURI property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/a/a4/Vaginal_opening_-_english_description.jpg" xsd:anyURI [Term] id: UBERON:0000997 name: mammalian vulva def: "External genital organs of the female mammal[WP]." [Wikipedia:Vulva] subset: efo_slim subset: pheno_slim subset: uberon_slim synonym: "female pudendum" EXACT DEPRECATED [BTO:0003101, doi:10.1002/ca.23705, FMA:20462] synonym: "mammalian vulva" EXACT [] synonym: "puboperineal region" EXACT [FMA:20462] synonym: "pudendum" RELATED DEPRECATED [BTO:0003101, doi:10.1002/ca.23705] synonym: "pudendum femininum" EXACT DEPRECATED [doi:10.1002/ca.23705, FMA:20462, FMA:TA] synonym: "pudendum femininum" RELATED DEPRECATED [doi:10.1002/ca.23705, Wikipedia:Vulva] synonym: "pudendum muliebre" RELATED DEPRECATED [BTO:0003101, doi:10.1002/ca.23705] synonym: "vulva" EXACT [MA:0000395] xref: BTO:0003101 xref: CALOHA:TS-1168 xref: EFO:0000978 xref: EMAPA:36631 xref: EV:0100118 xref: FMA:20462 xref: GAID:383 xref: galen:Vulva xref: MA:0000395 xref: MAT:0000169 xref: MESH:D014844 xref: MIAA:0000169 xref: NCIT:C12408 xref: SCTID:265796001 xref: UMLS:C0042993 {source="ncithesaurus:Vulva"} xref: VHOG:0001458 xref: Wikipedia:Vulva is_a: UBERON:0000062 ! organ is_a: UBERON:0005156 ! reproductive structure relationship: BFO:0000050 UBERON:0005056 ! part of external female genitalia relationship: RO:0002162 NCBITaxon:40674 ! in taxon Mammalia property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/d/da/Female_unshaved_genitalia.jpg" xsd:anyURI [Term] id: UBERON:0000998 name: seminal vesicle def: "Either of a pair of glandular pouches that lie one on either side of the male reproductive tract posterolateral to the urinary bladder and in the human male secrete a sugar- and protein-containing fluid into the ejaculatory duct." [BTO:0001234, Wikipedia:Seminal_vesicle] subset: efo_slim subset: organ_slim subset: pheno_slim subset: uberon_slim synonym: "glandula seminalis" RELATED [BTO:0001234] synonym: "glandula vesiculosa" RELATED [BTO:0001234] synonym: "gonecyst" RELATED [] synonym: "seminal gland" BROAD [] synonym: "vas efferens" RELATED [] synonym: "vesicula seminalis" RELATED [BTO:0001234, Wikipedia:Seminal_vesicle] synonym: "vesiculae seminales" RELATED OMO:0003011 [Wikipedia:Seminal_vesicle] synonym: "vesicular gland" RELATED [Wikipedia:Seminal_vesicle] synonym: "vesicular glands" RELATED [Wikipedia:Seminal_vesicle] synonym: "vesicular seminalis" RELATED [Wikipedia:Seminal_vesicle] synonym: "vesiculæ seminales" RELATED [Wikipedia:Seminal_vesicle] xref: AAO:0010788 xref: BTO:0001234 xref: CALOHA:TS-0919 xref: EFO:0000986 xref: EMAPA:19180 xref: EV:0100106 xref: FMA:19386 xref: GAID:394 xref: MA:0000410 xref: MAT:0000171 xref: MESH:D012669 xref: MIAA:0000171 xref: NCIT:C12787 xref: SCTID:181434004 xref: UMLS:C0036628 {source="ncithesaurus:Seminal_Vesicle"} xref: VHOG:0001379 xref: Wikipedia:Seminal_vesicle is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0006868 ! seminal fluid secreting gland relationship: BFO:0000050 UBERON:0000473 ! part of testis relationship: RO:0002202 UBERON:0000080 ! develops from mesonephros relationship: RO:0002433 UBERON:0004054 ! contributes to morphology of internal male genitalia relationship: RO:0003000 UBERON:0010143 ! produces seminal vesicle fluid property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/d/d1/Male_anatomy_en.svg" xsd:anyURI property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/prostate-male/v1.2/assets/3d-vh-m-prostate.glb" xsd:anyURI [Term] id: UBERON:0000999 name: ejaculatory duct def: "The Ejaculatory ducts (ductus ejaculatorii) are paired structures in male anatomy, about 2 cm in length. Each ejaculatory duct is formed by the union of the vas deferens with the duct of the seminal vesicle. They pass through the prostate, and empty into the urethra at the Colliculus seminalis. During ejaculation, semen passes through the ducts and exits the body via the penis[WP,unvetted]." [Wikipedia:Ejaculatory_duct] subset: efo_slim subset: uberon_slim synonym: "ductus ejaculatorii" EXACT OMO:0003004 [BTO:0001580] synonym: "ductus ejaculatorii" RELATED OMO:0003011 [Wikipedia:Ejaculatory_duct] synonym: "ductus ejaculatorius" EXACT [BTO:0001580] xref: BTO:0001580 xref: CALOHA:TS-0211 xref: EFO:0000985 xref: EMAPA:19088 xref: FMA:19325 xref: GAID:388 xref: MA:0003247 xref: MAT:0000170 xref: MESH:D004543 xref: MIAA:0000170 xref: NCIT:C32493 xref: SCTID:279665005 xref: UMLS:C0013747 {source="ncithesaurus:Ejaculatory_Duct"} xref: Wikipedia:Ejaculatory_duct is_a: UBERON:0000025 ! tube is_a: UBERON:0005904 ! duct of male reproductive system is_a: UBERON:0015212 ! lateral structure relationship: BSPO:0000126 UBERON:0000079 ! male reproductive system relationship: channel_for UBERON:0001968 ! semen relationship: channel_for UBERON:0010143 ! seminal vesicle fluid relationship: channels_from UBERON:0000998 ! seminal vesicle relationship: channels_from UBERON:0001000 ! vas deferens relationship: channels_into UBERON:0000057 ! urethra relationship: RO:0002162 NCBITaxon:7742 ! in taxon Vertebrata relationship: RO:0002216 GO:0042713 ! capable of part of sperm ejaculation property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/prostate-male/v1.2/assets/3d-vh-m-prostate.glb" xsd:anyURI property_value: foaf:depiction "https://upload.wikimedia.org/wikipedia/commons/3/35/Male_anatomy.png" xsd:anyURI [Term] id: UBERON:0001000 name: vas deferens def: "A secretory duct that transports sperm from the testis. In mammals this is a continuation of the epididymis and ends in the prostatic urethra where it terminates to form ejaculatory duct." [http://orcid.org/0000-0002-6601-2165, ISBN:0-683-40008-8, MGI:pvb, MP:0002769, Wikipedia:Vas_deferens] subset: efo_slim subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "deferent duct" EXACT [] synonym: "ductus deferens" EXACT [Wikipedia:Vas_deferens] synonym: "sperm duct" RELATED [] synonym: "vas deferen" EXACT [] synonym: "vasa deferentia" RELATED [] xref: BTO:0001427 xref: CALOHA:TS-1105 xref: EFO:0000981 xref: EMAPA:18681 xref: EV:0100105 xref: FMA:19234 xref: GAID:404 xref: galen:VasDeferens xref: MA:0000413 xref: MESH:D014649 xref: MIAA:0000129 xref: NCIT:C12813 xref: SCTID:245467009 xref: UMLS:C0042360 {source="ncithesaurus:Vas_Deferens"} xref: VHOG:0001135 xref: Wikipedia:Vas_deferens is_a: UBERON:0000025 ! tube is_a: UBERON:0005904 ! duct of male reproductive system relationship: BFO:0000050 UBERON:0005352 {source="FMA"} ! part of spermatic cord relationship: BFO:0000050 UBERON:0006947 ! part of male genital duct relationship: channel_for UBERON:0001968 ! semen relationship: channels_from UBERON:0001301 ! epididymis relationship: channels_into UBERON:0000999 ! ejaculatory duct relationship: RO:0002433 UBERON:0004054 ! contributes to morphology of internal male genitalia property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/d/d1/Male_anatomy_en.svg" xsd:anyURI [Term] id: UBERON:0001003 name: skin epidermis def: "The outer epithelial layer of the skin that is superficial to the dermis." [http://orcid.org/0000-0002-6601-2165, ISBN:0073040584] subset: efo_slim subset: human_reference_atlas subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "epidermis" BROAD [] synonym: "skin" BROAD [] synonym: "vertebrate epidermis" EXACT [] xref: AAO:0000143 xref: BTO:0000404 xref: CALOHA:TS-0283 xref: EFO:0000954 xref: EMAPA:17528 xref: EV:0100153 xref: FMA:70596 xref: GAID:932 xref: MA:0000153 xref: MAT:0000154 xref: MESH:D004817 xref: MIAA:0000154 xref: NCIT:C12708 xref: SCTID:361694003 xref: TAO:0000105 xref: UMLS:C0014520 {source="ncithesaurus:Epidermis"} xref: VHOG:0000077 xref: Wikipedia:Epidermis_(skin) xref: XAO:0000028 xref: ZFA:0000105 is_a: UBERON:0007376 ! outer epithelium is_a: UBERON:3000961 ! external integument structure intersection_of: UBERON:0007376 ! outer epithelium intersection_of: BFO:0000050 UBERON:0002097 ! part of skin of body relationship: BFO:0000050 UBERON:0002097 ! part of skin of body relationship: RO:0002220 UBERON:0002067 ! adjacent to dermis relationship: RO:0002285 UBERON:0003055 ! developmentally replaces periderm property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "skin epidermis" xsd:string [Term] id: UBERON:0001004 name: respiratory system def: "Functional system which consists of structures involved in respiration." [http://orcid.org/0000-0002-6601-2165, Wikipedia:Respiratory_system] subset: efo_slim subset: functional_classification subset: human_reference_atlas subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "apparatus respiratorius" EXACT [] synonym: "apparatus respiratorius" RELATED [BTO:0000203] synonym: "Atmungssystem" RELATED [BTO:0000203] synonym: "respiratory system" EXACT [] synonym: "systema respiratorium" RELATED OMO:0003011 [Wikipedia:Respiratory_system] xref: AAO:0000541 xref: BTO:0000203 xref: CALOHA:TS-1319 xref: EFO:0000804 xref: EHDAA2:0001604 xref: EHDAA:2203 xref: EMAPA:16727 xref: EV:0100036 xref: FMA:7158 xref: GAID:78 xref: MA:0000327 xref: MAT:0000030 xref: MESH:D012137 xref: MIAA:0000030 xref: NCIT:C12779 xref: SCTID:278197002 xref: TAO:0000272 xref: UMLS:C0035237 {source="ncithesaurus:Respiratory_System"} xref: VHOG:0000202 xref: Wikipedia:Respiratory_system xref: XAO:0000117 xref: ZFA:0000272 is_a: UBERON:0000467 ! anatomical system intersection_of: UBERON:0000467 ! anatomical system intersection_of: RO:0002215 GO:0007585 ! capable of respiratory gaseous exchange by respiratory system disjoint_from: UBERON:0001007 ! digestive system disjoint_from: UBERON:0001009 ! circulatory system disjoint_from: UBERON:0001016 ! nervous system disjoint_from: UBERON:0001033 ! gustatory system disjoint_from: UBERON:0001434 ! skeletal system disjoint_from: UBERON:0002204 ! musculoskeletal system disjoint_from: UBERON:0002294 ! biliary system disjoint_from: UBERON:0002330 ! exocrine system disjoint_from: UBERON:0002390 ! hematopoietic system disjoint_from: UBERON:0002405 ! immune system disjoint_from: UBERON:0002416 ! integumental system disjoint_from: UBERON:0002423 ! hepatobiliary system disjoint_from: UBERON:0004456 ! entire sense organ system disjoint_from: UBERON:8450002 ! excretory system relationship: RO:0002162 NCBITaxon:33213 ! in taxon Bilateria relationship: RO:0002215 GO:0003016 ! capable of respiratory system process relationship: RO:0002215 GO:0007585 ! capable of respiratory gaseous exchange by respiratory system relationship: RO:0002492 UBERON:0000066 ! existence ends during fully formed stage property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/5/5e/Respiratory_system_complete_en.svg" xsd:anyURI property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/lung-female/v1.4/assets/3d-vh-f-lung.glb" xsd:anyURI property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/lung-male/v1.4/assets/3d-vh-m-lung.glb" xsd:anyURI property_value: RO:0002161 NCBITaxon:147099 {source="Wikipedia:Acoelomorpha"} property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "respiratory system" xsd:string [Term] id: UBERON:0001005 name: respiratory airway def: "An airway through which respiratory air passes in organisms." [Wikipedia:Trachea] subset: grouping_class subset: uberon_slim synonym: "airway" BROAD [http://orcid.org/0000-0002-6601-2165] synonym: "airways" BROAD OMO:0003004 [http://orcid.org/0000-0002-6601-2165] xref: SCTID:361380005 xref: Wikipedia:Trachea is_a: UBERON:0003103 ! compound organ is_a: UBERON:0004111 ! anatomical conduit relationship: BFO:0000050 UBERON:0001004 ! part of respiratory system relationship: channel_for UBERON:0034874 ! air in respiratory system property_value: skos:prefLabel "respiratory airway" xsd:string [Term] id: UBERON:0001007 name: digestive system def: "Anatomical system that has as its parts the organs devoted to the ingestion, digestion, and assimilation of food and the discharge of residual wastes." [FB:gg, NLM:alimentary+system, Wikipedia:Digestive_system] subset: efo_slim subset: human_reference_atlas subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "alimentary system" RELATED [] synonym: "alimentary tract" RELATED [] synonym: "gastrointestinal system" RELATED [] synonym: "gut" RELATED [] xref: AAO:0000129 xref: BILA:0000082 xref: BTO:0000058 xref: CALOHA:TS-1293 xref: EFO:0000793 xref: FBbt:00005055 {sssom:mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"} xref: FMA:7152 xref: GAID:278 xref: galen:DigestiveSystem xref: MA:0002431 xref: MAT:0000018 xref: MESH:D004064 xref: MIAA:0000018 xref: ncithesaurus:Digestive_System xref: SCTID:278859004 xref: TADS:0000170 xref: TAO:0000339 xref: WBbt:0005748 xref: Wikipedia:Digestive_system xref: XAO:0000125 xref: ZFA:0000339 is_a: UBERON:0000467 ! anatomical system intersection_of: UBERON:0000467 ! anatomical system intersection_of: RO:0002215 GO:0022600 ! capable of digestive system process disjoint_from: UBERON:0001009 ! circulatory system disjoint_from: UBERON:0001016 ! nervous system disjoint_from: UBERON:0001033 ! gustatory system disjoint_from: UBERON:0001434 ! skeletal system disjoint_from: UBERON:0002204 ! musculoskeletal system disjoint_from: UBERON:0002294 ! biliary system disjoint_from: UBERON:0002330 ! exocrine system disjoint_from: UBERON:0002390 ! hematopoietic system disjoint_from: UBERON:0002405 ! immune system disjoint_from: UBERON:0002416 ! integumental system disjoint_from: UBERON:0002423 ! hepatobiliary system disjoint_from: UBERON:0004456 ! entire sense organ system disjoint_from: UBERON:8450002 ! excretory system relationship: RO:0002215 GO:0022600 ! capable of digestive system process relationship: RO:0002492 UBERON:0000066 ! existence ends during fully formed stage property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "digestive system" xsd:string [Term] id: UBERON:0001008 name: renal system def: "The renal system in an anatomical system that maintains fluid balance and contributes to electrolyte balance, acid/base balance, and disposal of nitrogenous waste products." [DOI:10.1371/journal.pone.0099864, GO:0072001] comment: EDITOR_NOTE In various sources such as Encyclopedia Britannica, the excretory and urinary systems are indeed the same system (see wikipedia talk page); we merge two BTO classes here subset: efo_slim subset: human_reference_atlas subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "excretory system" BROAD [] synonym: "renal or urinary system" RELATED [EHDAA:5901] synonym: "renal/urinary system" RELATED [] synonym: "systema urinaria" EXACT [FMA:7159] synonym: "systema urinarium" EXACT [BTO:0003092] synonym: "urinary system" EXACT [] synonym: "urinary tract" EXACT [] xref: AAO:0010257 xref: BILA:0000015 xref: BTO:0001244 xref: BTO:0003092 xref: CALOHA:TS-1323 xref: EFO:0000803 xref: EHDAA2:0001601 xref: EHDAA:5901 xref: EMAPA:17366 xref: EV:0100095 xref: FBbt:00005056 {sssom:mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"} xref: FMA:7159 xref: GAID:391 xref: galen:UrinaryTract xref: MA:0000325 xref: MAT:0000027 xref: MESH:D014551 xref: MIAA:0000027 xref: NCIT:C12413 xref: SCTID:362204003 xref: TADS:0000162 xref: TAO:0000163 xref: UMLS:C1508753 {source="ncithesaurus:Urinary_System"} xref: VHOG:0000723 xref: WBbt:0005736 xref: Wikipedia:Excretory_system xref: XAO:0000143 xref: ZFA:0000163 is_a: UBERON:8450002 ! excretory system intersection_of: UBERON:8450002 ! excretory system intersection_of: RO:0002215 GO:0097254 ! capable of renal tubular secretion relationship: RO:0002162 NCBITaxon:6072 ! in taxon Eumetazoa relationship: RO:0002215 GO:0097254 ! capable of renal tubular secretion relationship: RO:0002492 UBERON:0000066 ! existence ends during fully formed stage property_value: RO:0002161 NCBITaxon:110815 {source="Wikipedia"} property_value: RO:0002161 NCBITaxon:147099 {source="Wikipedia:Acoelomorpha"} property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "renal system" xsd:string [Term] id: UBERON:0001009 name: circulatory system def: "Organ system that passes nutrients (such as amino acids and electrolytes), gases, hormones, blood cells, etc. to and from cells in the body to help fight diseases and help stabilize body temperature and pH to maintain homeostasis[WP]." [Wikipedia:Circulatory_system] subset: uberon_slim synonym: "systema cardiovasculare" RELATED OMO:0003011 [Wikipedia:Circulatory_system] xref: AAO:0000959 xref: CALOHA:TS-2103 xref: MESH:D002319 {sssom:mapping_justification="https://w3id.org/semapv/vocab/LexicalMatching"} xref: VHOG:0001248 xref: Wikipedia:Circulatory_system is_a: UBERON:0000467 ! anatomical system disjoint_from: UBERON:0001016 ! nervous system disjoint_from: UBERON:0001033 ! gustatory system disjoint_from: UBERON:0001434 ! skeletal system disjoint_from: UBERON:0002204 ! musculoskeletal system disjoint_from: UBERON:0002294 ! biliary system disjoint_from: UBERON:0002330 ! exocrine system disjoint_from: UBERON:0002390 ! hematopoietic system disjoint_from: UBERON:0002405 ! immune system disjoint_from: UBERON:0002416 ! integumental system disjoint_from: UBERON:0002423 ! hepatobiliary system disjoint_from: UBERON:0004456 ! entire sense organ system disjoint_from: UBERON:8450002 ! excretory system relationship: RO:0002162 NCBITaxon:33213 ! in taxon Bilateria relationship: RO:0002215 GO:0003013 ! capable of circulatory system process relationship: RO:0002492 UBERON:0000066 ! existence ends during fully formed stage property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/2/29/Circulatory_System_en.svg" xsd:anyURI property_value: RO:0002161 NCBITaxon:147099 {source="Wikipedia:Acoelomorpha"} property_value: RO:0002161 NCBITaxon:6073 property_value: RO:0002161 NCBITaxon:6157 property_value: skos:prefLabel "circulatory system" xsd:string [Term] id: UBERON:0001013 name: adipose tissue def: "Portion of connective tissue composed of adipocytes enmeshed in areolar tissue." [http://orcid.org/0000-0002-6601-2165, MESH:A10.165.114, MGI:cwg, MP:0000003, Wikipedia:Adipose_tissue] subset: efo_slim subset: human_reference_atlas subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "adipose" RELATED [BTO:0001487] synonym: "bodyfat" RELATED [BTO:0001487] synonym: "fat" EXACT [MA:0000009] synonym: "fat tissue" EXACT [] synonym: "fatty depot" RELATED [] synonym: "fatty tissue" EXACT [] xref: AAO:0000001 xref: AEO:000020 xref: BTO:0001487 xref: CALOHA:TS-0013 xref: EFO:0000790 xref: EHDAA2:0003120 xref: EMAPA:35112 xref: EV:0100381 xref: FMA:20110 xref: GAID:920 xref: galen:FattyTissue xref: MA:0000009 xref: MAT:0000015 xref: MESH:D000273 xref: MIAA:0000015 xref: NCIT:C12472 xref: SCTID:55603005 xref: TAO:0002134 xref: UMLS:C0001527 {source="ncithesaurus:Adipose_Tissue"} xref: VHOG:0001284 xref: Wikipedia:Adipose_tissue xref: XAO:0003049 xref: ZFA:0005345 is_a: BFO:0000002 is_a: UBERON:0011822 {source="FMA"} ! dense irregular connective tissue intersection_of: UBERON:0002384 ! connective tissue intersection_of: RO:0002473 CL:0000136 ! composed primarily of adipocyte disjoint_from: UBERON:0003714 ! neural tissue relationship: RO:0002473 CL:0000136 ! composed primarily of adipocyte property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "adipose tissue" xsd:string [Term] id: UBERON:0001015 name: musculature def: "A subdivision of the muscular system corresponding to a subdisivision of an organism." [https://orcid.org/0000-0002-6601-2165, Wikipedia:Muscular_system] subset: efo_slim subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "muscle group" EXACT [] synonym: "muscle system" RELATED [] synonym: "muscles" RELATED [] synonym: "muscles set" EXACT [] synonym: "musculature" EXACT [] synonym: "musculature system" RELATED [] synonym: "musculi" EXACT OMO:0003011 [FMA:32558, FMA:TA] synonym: "set of muscles" EXACT [FMA:32558] synonym: "set of skeletal muscles" EXACT [MA:0000165] xref: BTO:0000887 xref: EFO:0001949 xref: EMAPA:35577 xref: FMA:32558 xref: MA:0000165 xref: NCIT:C13056 xref: TAO:0000548 xref: UMLS:C0026845 {source="ncithesaurus:Muscle"} xref: VSAO:0005038 xref: WBbt:0005737 xref: Wikipedia:Muscular_system xref: ZFA:0000548 is_a: BFO:0000002 is_a: UBERON:0011216 ! organ system subdivision relationship: BFO:0000050 UBERON:0000383 ! part of musculature of body relationship: RO:0002473 UBERON:0001630 ! composed primarily of muscle organ property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/e/e5/Muscles_anterior_labeled.png" xsd:anyURI property_value: skos:prefLabel "musculature" xsd:string [Term] id: UBERON:0001016 name: nervous system def: "The nervous system is an organ system containing predominantly neuron and glial cells. In bilaterally symmetrical organism, it is arranged in a network of tree-like structures connected to a central body. The main functions of the nervous system are to regulate and control body functions, and to receive sensory input, process this information, and generate behavior [CUMBO]." [BIRNLEX:844, ISBN:0-14-051288-8, ISBN:3110148986, NLM:nervous+system, WB:rynl, Wikipedia:Nervous_system, ZFIN:curator] subset: cumbo subset: efo_slim subset: human_reference_atlas subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "nerve net" NARROW [Wikipedia:Nerve_net] synonym: "neurological system" EXACT [GO:0050877] synonym: "systema nervosum" RELATED OMO:0003011 [Wikipedia:Nervous_system] xref: AAO:0000324 xref: BILA:0000079 xref: BIRNLEX:844 xref: BTO:0001484 xref: CALOHA:TS-1313 xref: EFO:0000802 xref: EHDAA2:0001246 xref: EHDAA:826 xref: EMAPA:16469 xref: EV:0100162 xref: FBbt:00005093 {sssom:mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"} xref: FMA:7157 xref: GAID:466 xref: MA:0000016 xref: MAT:0000026 xref: MESH:D009420 xref: MIAA:0000026 xref: NCIT:C12755 xref: neuronames:3236 xref: SCTID:278196006 xref: TAO:0000396 xref: UMLS:C0027763 {source="ncithesaurus:Nervous_System"} xref: VHOG:0000402 xref: WBbt:0005735 xref: Wikipedia:Nervous_system xref: XAO:0000177 xref: ZFA:0000396 is_a: BFO:0000002 is_a: UBERON:0000467 ! anatomical system disjoint_from: UBERON:0001033 ! gustatory system disjoint_from: UBERON:0001434 ! skeletal system disjoint_from: UBERON:0002204 ! musculoskeletal system disjoint_from: UBERON:0002294 ! biliary system disjoint_from: UBERON:0002330 ! exocrine system disjoint_from: UBERON:0002390 ! hematopoietic system disjoint_from: UBERON:0002405 ! immune system disjoint_from: UBERON:0002416 ! integumental system disjoint_from: UBERON:0002423 ! hepatobiliary system disjoint_from: UBERON:0004456 ! entire sense organ system disjoint_from: UBERON:8450002 ! excretory system relationship: BFO:0000051 CL:0000540 ! has part neuron relationship: RO:0002215 GO:0050877 ! capable of nervous system process relationship: RO:0002473 CL:0002319 ! composed primarily of neural cell relationship: RO:0002492 UBERON:0000066 ! existence ends during fully formed stage relationship: RO:0002495 UBERON:0016880 {source="Bgee:AN"} ! immediate transformation of future nervous system property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/b/b2/TE-Nervous_system_diagram.svg" xsd:anyURI property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/b/ba/Nervous_system_diagram.png" xsd:anyURI property_value: RO:0002161 NCBITaxon:6040 property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "nervous system" xsd:string [Term] id: UBERON:0001017 name: central nervous system def: "The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the neural tube derivatives: the brain and spinal cord. In invertebrates it includes central ganglia plus nerve cord." [GO:0021551, http://www.frontiersinzoology.com/content/7/1/29, https://sourceforge.net/p/geneontology/ontology-requests/11422/] subset: cumbo subset: efo_slim subset: human_reference_atlas subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "cerebrospinal axis" NARROW [FMA:55675] synonym: "CNS" EXACT OMO:0003000 [] synonym: "neuraxis" RELATED [FMA:55675] synonym: "systema nervosum centrale" EXACT OMO:0003011 [FMA:55675, FMA:TA] xref: AAO:0000090 xref: BAMS:CNS xref: BILA:0000080 xref: BIRNLEX:1099 xref: BTO:0000227 xref: CALOHA:TS-0150 xref: EFO:0000908 xref: EHDAA2:0000225 xref: EHDAA:828 xref: EMAPA:16470 xref: EMAPA:16754 xref: EV:0100163 xref: FBbt:00005094 {sssom:mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"} xref: FMA:55675 xref: GAID:570 xref: MA:0000167 xref: MAT:0000457 xref: MESH:D002490 xref: NCIT:C12438 xref: neuronames:854 xref: SCTID:278199004 xref: TAO:0000012 xref: UMLS:C0927232 {source="ncithesaurus:Central_Nervous_System", source="BIRNLEX:1099"} xref: VHOG:0000293 xref: Wikipedia:Central_nervous_system xref: XAO:0000215 xref: ZFA:0000012 is_a: UBERON:0004121 ! ectoderm-derived structure is_a: UBERON:0011216 {source="FBbt", source="cjm"} ! organ system subdivision relationship: BFO:0000050 UBERON:0001016 ! part of nervous system relationship: RO:0002495 UBERON:0016879 {source="Bgee:AN"} ! immediate transformation of future central nervous system property_value: RO:0002161 NCBITaxon:147099 {source="Wikipedia:Acoelomorpha"} property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "central nervous system" xsd:string [Term] id: UBERON:0001018 name: axon tract def: "A group of axons linking two or more neuropils and having a common origin, termination[FBbt]." [http://flybrain.uni-freiburg.de/Flybrain/html/terms/terms.html, https://github.com/obophenotype/uberon/issues/286] comment: WP says this is the analog of peripheral nerves in CNS. subset: cumbo subset: pheno_slim synonym: "axonal tract" EXACT [] synonym: "nerve tract" NARROW [BIRNLEX:1649] synonym: "nerve tract" RELATED [] synonym: "neuraxis tract" EXACT [FMA:83847] synonym: "tract" RELATED [] synonym: "tract of neuraxis" EXACT [FMA:83847] xref: BIRNLEX:1649 xref: EV:0100304 xref: FBbt:00005100 {sssom:mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"} xref: FMA:83847 xref: NLX:147822 is_a: UBERON:0000122 ! neuron projection bundle is_a: UBERON:0011215 ! central nervous system cell part cluster property_value: skos:prefLabel "axon tract" xsd:string [Term] id: UBERON:0001019 name: nerve fasciculus def: "A slender neuron projection bundle[FBbt]; A bundle of anatomical fibers, as of muscle or nerve (American Heritage Dictionary 4th ed)." [BIRNLEX:872, FBbt:00005101] comment: EDITOR_NOTE note FBbt class not disjoint from tract. Consider merging with 'neuron projection bundle' subset: uberon_slim synonym: "fascicle" BROAD [FBbt:00005101] synonym: "fasciculus" EXACT OMO:0003011 [] synonym: "nerve bundle" EXACT [FMA:12235] synonym: "nerve fasciculus" EXACT [FMA:12235] synonym: "nerve fiber tract" RELATED [BTO:0002191] synonym: "neural fasciculus" EXACT [FMA:12235] xref: BIRNLEX:872 xref: BTO:0002191 xref: EMAPA:36605 xref: FMA:12235 xref: NCIT:C32586 xref: TGMA:0000088 xref: UMLS:C1185741 {source="ncithesaurus:Fascicle"} xref: Wikipedia:Nervous_system_fascicle is_a: UBERON:0000122 ! neuron projection bundle property_value: skos:prefLabel "nerve fasciculus" xsd:string [Term] id: UBERON:0001020 name: nervous system commissure def: "Axon tract that crosses the midline of the central nervous system[NIF, modified]. In the context of Drosophila refers to a broad band of axons connecting equivalent neuropils each side of the brain[FBbt]." [https://github.com/obophenotype/uberon/issues/300, https://github.com/obophenotype/uberon/issues/325, NLXANAT:20090513] comment: *not* the same as FMA:76741 Commissure subset: cumbo subset: uberon_slim synonym: "commissure" BROAD [] synonym: "commissure of neuraxis" EXACT [FMA:83906] synonym: "neuraxis commissure" EXACT [FMA:83906] synonym: "white matter commissure" NARROW [CUMBO:CUMBO] xref: FMA:83906 xref: NCIT:C32349 xref: NLX:110 xref: NLXANAT:20090513 xref: TADS:0000201 xref: UMLS:C1185742 {source="ncithesaurus:Commissure"} xref: Wikipedia:Commissure is_a: UBERON:0001018 ! axon tract relationship: BSPO:0005001 UBERON:0001016 ! nervous system property_value: skos:prefLabel "nervous system commissure" xsd:string property_value: terms:contributor https://orcid.org/0000-0001-9114-8737 property_value: terms:contributor https://orcid.org/0000-0002-6601-2165 [Term] id: UBERON:0001021 name: nerve def: "An enclosed, cable-like bundle of axons in the peripheral nervous system originating in a nerve root in the central nervous system (or a condensed nervous structure) connecting with peripheral structures." [FBbt:00005105, http://orcid.org/0000-0002-6601-2165] subset: human_reference_atlas subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "nerves" EXACT OMO:0003004 [TAO:0007009] synonym: "neural subtree" RELATED [FMA:65132] synonym: "peripheral nerve" EXACT [http://orcid.org/0000-0002-6601-2165] xref: AAO:0011070 xref: AEO:0000137 xref: BAMS:n xref: BIRNLEX:1615 xref: BSA:0000098 xref: BTO:0000925 xref: BTO:0001027 xref: CALOHA:TS-0772 xref: EHDAA2:0003137 xref: EHDAA:2851 xref: EHDAA:3776 xref: EHDAA:4657 xref: EMAPA:32808 xref: EMAPA:32815 xref: EV:0100371 xref: FBbt:00005105 {sssom:mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"} xref: FMA:65132 xref: FMA:65239 xref: GAID:747 xref: GAID:758 xref: galen:Nerve xref: MA:0000217 xref: MA:0000228 xref: MESH:D010525 xref: NCIT:C12466 xref: NCIT:C12768 xref: NLX:147826 xref: SCTID:244457007 xref: SCTID:256864008 xref: TAO:0007009 xref: UMLS:C0027740 {source="ncithesaurus:Nerve"} xref: UMLS:C0031119 {source="ncithesaurus:Peripheral_Nerve"} xref: VHOG:0000901 xref: Wikipedia:Nervous_system xref: XAO:0000204 xref: XAO:0003047 xref: ZFA:0007009 is_a: UBERON:0000122 {source="FBbt"} ! neuron projection bundle relationship: BFO:0000050 UBERON:0000010 ! part of peripheral nervous system relationship: RO:0000086 PATO:0002045 ! has quality dendritic property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "nerve" xsd:string [Term] id: UBERON:0001027 name: sensory nerve def: "A nerve that transmits from sensory receptors on the surface of the body to the central nervous system." [UBERON:cjm, Wikipedia:Sensory_nerve] subset: pheno_slim subset: uberon_slim synonym: "afferent nerve" RELATED [] synonym: "nervus sensorius" EXACT OMO:0003011 [Wikipedia:Sensory_nerve] xref: AEO:0000201 xref: EHDAA2:0003200 xref: FBbt:00005136 {sssom:mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"} xref: FMA:5868 xref: Wikipedia:Sensory_nerve is_a: UBERON:0001021 ! nerve relationship: BFO:0000051 CL:0000526 {source="AEO"} ! has part afferent neuron property_value: skos:prefLabel "sensory nerve" xsd:string [Term] id: UBERON:0001032 name: sensory system def: "Anatomical system that overlaps the nervous system and is responsible for receiving and processing sensory information." [Wikipedia:Sensory_system] subset: efo_slim subset: human_reference_atlas subset: uberon_slim subset: vertebrate_core synonym: "organa sensuum" EXACT OMO:0003011 [FMA:75259, FMA:TA] synonym: "organa sensuum" RELATED OMO:0003011 [Wikipedia:Sensory_system] synonym: "sense organ subsystem" EXACT [] synonym: "sense organs" EXACT [FMA:75259] synonym: "sense organs set" EXACT [FMA:75259] synonym: "sensory organ system" RELATED [] synonym: "sensory subsystem" EXACT [] synonym: "sensory systems" EXACT OMO:0003004 [TAO:0000282] synonym: "set of sense organs" RELATED [FMA:75259] xref: AAO:0000555 xref: BAMS:SEN xref: BILA:0000099 xref: EFO:0000805 xref: EHDAA2:0003094 xref: EMAPA:16192 xref: FBbt:00007692 {sssom:mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"} xref: FMA:75259 xref: MA:0002442 xref: MAT:0000031 xref: MIAA:0000031 xref: NLXANAT:090816 xref: TAO:0000282 xref: VHOG:0001674 xref: Wikipedia:Sensory_system xref: XAO:0003194 xref: ZFA:0000282 is_a: BFO:0000004 is_a: UBERON:0015203 ! non-connected functional system relationship: BFO:0000050 UBERON:0004456 ! part of entire sense organ system relationship: RO:0002131 UBERON:0001016 ! overlaps nervous system relationship: RO:0002216 GO:0007600 ! capable of part of sensory perception property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/c/c0/Gray722.png" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "sensory system" xsd:string [Term] id: UBERON:0001033 name: gustatory system def: "The sensory system for the sense of taste." [NLXANAT:090803] subset: efo_slim subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "gustatory organ system" EXACT [] synonym: "taste system" EXACT [] xref: AAO:0010577 xref: BILA:0000143 xref: EFO:0000830 xref: FMA:7194 xref: MA:0002446 xref: MAT:0000275 xref: MIAA:0000275 xref: neuronames:2889 xref: NLXANAT:090803 xref: SCTID:423940004 xref: TAO:0001101 xref: Wikipedia:Gustatory_system xref: XAO:0003197 xref: ZFA:0001101 is_a: UBERON:0000467 ! anatomical system intersection_of: UBERON:0000467 ! anatomical system intersection_of: RO:0002216 GO:0050912 ! capable of part of detection of chemical stimulus involved in sensory perception of taste disjoint_from: UBERON:0001434 ! skeletal system disjoint_from: UBERON:0002204 ! musculoskeletal system disjoint_from: UBERON:0002294 ! biliary system disjoint_from: UBERON:0002330 ! exocrine system disjoint_from: UBERON:0002390 ! hematopoietic system disjoint_from: UBERON:0002405 ! immune system disjoint_from: UBERON:0002416 ! integumental system disjoint_from: UBERON:0002423 ! hepatobiliary system disjoint_from: UBERON:0004456 ! entire sense organ system disjoint_from: UBERON:8450002 ! excretory system relationship: RO:0002162 NCBITaxon:6072 ! in taxon Eumetazoa relationship: RO:0002216 GO:0050912 ! capable of part of detection of chemical stimulus involved in sensory perception of taste relationship: RO:0002492 UBERON:0000066 ! existence ends during fully formed stage property_value: skos:prefLabel "gustatory system" xsd:string [Term] id: UBERON:0001037 name: strand of hair def: "A filament, mostly protein, that grows from follicles found in the dermis[WP]." [Wikipedia:Hair] subset: efo_slim subset: pheno_slim subset: uberon_slim synonym: "coat hair" RELATED [] synonym: "coat/ hair" RELATED [] synonym: "fur" RELATED [] synonym: "hair" EXACT [] synonym: "microchaeta" RELATED [] synonym: "quill" RELATED SENSU [] synonym: "setulae" RELATED [] synonym: "vibrissa" RELATED SENSU [] synonym: "whisker" RELATED SENSU [] xref: BTO:0001501 xref: CALOHA:TS-0430 xref: EFO:0000958 xref: EMAPA:18769 xref: EV:0100157 xref: FMA:53667 xref: GAID:71 xref: MA:0000155 xref: MAT:0000160 xref: MESH:D006197 xref: MIAA:0000160 xref: NCIT:C32705 xref: SCTID:361702001 xref: UMLS:C0018494 {source="ncithesaurus:Hair"} xref: VHOG:0001191 xref: Wikipedia:Hair is_a: BFO:0000002 is_a: UBERON:0000021 {source="FMA"} ! cutaneous appendage relationship: BFO:0000050 UBERON:0001003 {source="FMA"} ! part of skin epidermis relationship: BFO:0000050 UBERON:0011932 {source="FMA"} ! part of pilosebaceous unit relationship: BFO:0000051 GO:0045095 ! has part keratin filament relationship: RO:0002202 UBERON:0002073 ! develops from hair follicle property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/2/25/Gray945.png" xsd:anyURI property_value: IAO:0000116 "TODO for now we treat vibrissa/whisker as a syonym, but these have different follicles. We could introduce subclasses (see also: Pangolin scales)" xsd:string [Term] id: UBERON:0001038 name: chordotonal organ def: "Chordotonal organs are arthropod sensory structures consisting of special sensilla called the scolopidia, which are mechano-transducers and respond mainly to stretch or flexion. In insects, they consist of bundles of internal sensilla, each of which has a cap cell, an enveloping cell and one or more sense cells. The distal end of the organ is usually attached to the cuticle of the body wall, marked by a pit, a thickened disc or a nodule of chitin, and the base of the organ is connected with the hypodermis, often by a special ligament." [FB:FBrf0056378, Wikipedia:Chordotonal_organ] comment: To be ceded to Arthropod anatomy ontology subset: efo_slim subset: organ_slim subset: uberon_slim synonym: "ch" RELATED [] synonym: "scolopophorous organ" RELATED [] xref: EFO:0000940 xref: FBbt:00005215 {sssom:mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"} xref: MAT:0000209 xref: MIAA:0000209 xref: Wikipedia:Chordotonal_organ is_a: UBERON:0000020 ! sense organ relationship: RO:0002162 NCBITaxon:6656 ! in taxon Arthropoda [Term] id: UBERON:0001040 name: yolk sac def: "A sac-like expansion of the ventral wall of the intestine, narrowed into a yolk stalk near the body[Hyman's]. Membranous sac attached to an embryo, providing early nourishment in the form of yolk in bony fishes, sharks, reptiles, birds, and primitive mammals. It functions as the developmental circulatory system of the human embryo, before internal circulation begins. In the mouse, the yolk sac is the first site of blood formation, generating primitive macrophages and erythrocytes[WP]." [Wikipedia:Yolk_sac] subset: efo_slim subset: pheno_slim subset: uberon_slim synonym: "saccus vitellinus" RELATED OMO:0003011 [Wikipedia:Yolk_sac] synonym: "vesicula umbilicalis" RELATED OMO:0003011 [Wikipedia:Yolk_sac] xref: BTO:0001471 xref: CALOHA:TS-1130 xref: EFO:0003078 xref: EHDAA2:0002212 xref: EHDAA:164 xref: EMAPA:16085 xref: FMA:87180 xref: GAID:1301 xref: MESH:D015017 xref: NCIT:C14128 xref: SCTID:362845002 xref: UMLS:C0043425 {source="ncithesaurus:Yolk_Sac"} xref: VHOG:0000830 xref: Wikipedia:Yolk_sac is_a: BFO:0000002 is_a: UBERON:0005292 ! extraembryonic tissue is_a: UBERON:0005631 {seeAlso="https://github.com/obophenotype/uberon/issues/635"} ! extraembryonic membrane is_a: UBERON:0007499 {source="EHDAA2"} ! epithelial sac relationship: RO:0002254 UBERON:0000925 {source="ISBN:0073040584"} ! has developmental contribution from endoderm relationship: RO:0002254 UBERON:0004872 {source="ISBN:0073040584"} ! has developmental contribution from splanchnic layer of lateral plate mesoderm property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/1/17/Gray22.png" xsd:anyURI property_value: IAO:0000116 "consider splitting class" xsd:string property_value: skos:prefLabel "yolk sac" xsd:string [Term] id: UBERON:0001041 name: foregut def: "Anterior subdivision of a digestive tract." [http://orcid.org/0000-0002-6601-2165] subset: developmental_classification subset: pheno_slim subset: uberon_slim synonym: "praeenteron" RELATED OMO:0003011 [Wikipedia:Foregut] synonym: "proenteron" RELATED OMO:0003011 [Wikipedia:Foregut] xref: AAO:0011042 xref: BILA:0000085 xref: BTO:0000507 xref: EHDAA2:0000557 xref: EHDAA:520 xref: EMAPA:16548 xref: FBbt:00005379 {sssom:mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"} xref: FMA:45616 xref: MA:0001526 xref: NCIT:C34180 xref: SCTID:361409009 xref: TGMA:0001014 xref: UMLS:C0231051 {source="ncithesaurus:Foregut"} xref: VHOG:0000285 xref: Wikipedia:Foregut xref: XAO:0000232 is_a: UBERON:0004921 ! subdivision of digestive tract property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/9/9a/Gray27.png" xsd:anyURI property_value: IAO:0000116 "Note we define this generically to include invertebrates (partly for consistency with GO), but the class may be split in future. In vertebrates the term may refer to a developmental structure" xsd:string property_value: skos:prefLabel "foregut" xsd:string [Term] id: UBERON:0001042 name: chordate pharynx def: "A portion of the respiratory and digestive tracts; its distal limit is the superior part of the esophagus and it connects the nasal and oral cavities with the esophagus and larynx; it contains the valleculae and the pyriform recesses; its upper limits are the nasal cavity and cranial base.[FEED]." [http://www.feedexp.org] comment: Consider generalizing to deuterostome pharynx subset: efo_slim subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "pharynx" BROAD SENSU [FMA:46688] xref: AAO:0000967 xref: BTO:0001049 xref: CALOHA:TS-0785 xref: EFO:0000836 xref: EHDAA2:0001458 xref: EHDAA:2947 xref: EMAPA:16706 xref: EV:0100065 xref: FMA:46688 xref: GAID:155 xref: galen:Pharynx xref: MA:0000432 xref: MESH:D010614 xref: NCIT:C12425 xref: SCTID:181211006 xref: TAO:0000056 xref: UMLS:C0031354 {source="ncithesaurus:Pharynx"} xref: VHOG:0000462 xref: Wikipedia:Pharynx xref: XAO:0003227 xref: ZFA:0000056 is_a: BFO:0000002 is_a: UBERON:0006562 ! pharynx relationship: BFO:0000050 UBERON:0001004 ! part of respiratory system relationship: RO:0002162 NCBITaxon:7711 ! in taxon Chordata relationship: RO:0002202 UBERON:0009145 {source="EHDAA2"} ! develops from pharyngeal region of foregut property_value: skos:prefLabel "chordate pharynx" xsd:string [Term] id: UBERON:0001043 name: esophagus def: "Tube that connects the pharynx to the stomach. In mammals, the oesophagus connects the buccal cavity with the stomach. The stratified squamous non-keratinised epithelium lining the buccal cavity is continued through the pharynx down into the oesophagus. The lowest part of the oesophagus (ca. 2 cm) is lined with gastric mucosa and covered by peritoneum. The main body of the oesophagus is lined with small, simple mucous glands. Each gland opens into the lumen by a long duct which pierces the muscularis mucosae (Wilson and Washington, 1989). A sphincter is situated at the point where the oesophagus enters the stomach to prevent gastro-oesophageal reflux, i.e. to prevent acidic gastric contents from reaching stratified epithelia of the oesophagus, where they can cause inflammation and irritation (Wilson and Washington, 1989; Brown et al., 1993)." [http://www.rivm.nl/interspeciesinfo/inter/oesophagus/, Wikipedia:Esophagus] subset: efo_slim subset: human_reference_atlas subset: major_organ subset: organ_slim subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "gullet" EXACT [] synonym: "oesophagus" EXACT [] xref: AAO:0000145 xref: ANISEED:1235301 xref: BTO:0000959 xref: CALOHA:TS-0700 xref: EFO:0000835 xref: EHDAA2:0001285 xref: EHDAA:2937 xref: EMAPA:16833 xref: EV:0100069 xref: FMA:7131 xref: GAID:291 xref: galen:Esophagus xref: MA:0000352 xref: MAT:0000048 xref: MESH:D004947 xref: MIAA:0000048 xref: NCIT:C12389 xref: SCTID:181245004 xref: TAO:0000204 xref: UMLS:C0014876 {source="ncithesaurus:Esophagus"} xref: VHOG:0000450 xref: Wikipedia:Esophagus xref: XAO:0000127 xref: ZFA:0000204 is_a: BFO:0000002 is_a: UBERON:0004921 ! subdivision of digestive tract is_a: UBERON:0013765 ! digestive system element relationship: BFO:0000050 UBERON:0004908 ! part of upper digestive tract relationship: proximally_connected_to UBERON:0001042 ! chordate pharynx relationship: RO:0002202 UBERON:0001041 ! develops from foregut property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/d/d4/Illu01_head_neck.jpg" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "esophagus" xsd:string [Term] id: UBERON:0001044 name: saliva-secreting gland def: "Saliva-secreting exocrine glands of the oral cavity[GO]." [GO:0007431, Wikipedia:Salivary_gland] subset: efo_slim subset: functional_classification subset: human_reference_atlas subset: organ_slim subset: pheno_slim subset: uberon_slim synonym: "glandulae salivariae" RELATED OMO:0003011 [Wikipedia:Salivary_gland] synonym: "salivary gland" EXACT [MA:0000346] xref: BTO:0001203 xref: CALOHA:TS-0892 xref: EFO:0000859 xref: EHDAA2:0001775 xref: EHDAA:7987 xref: EMAPA:17751 xref: EV:0100059 xref: FBbt:00005382 {sssom:mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"} xref: FMA:9597 xref: GAID:937 xref: galen:SalivaryGland xref: MA:0000346 xref: MAT:0000079 xref: MESH:D012469 xref: MIAA:0000079 xref: NCIT:C12426 xref: SCTID:181236000 xref: UMLS:C0036098 {source="ncithesaurus:Salivary_Gland"} xref: VHOG:0000376 xref: Wikipedia:Salivary_gland is_a: UBERON:0010047 ! oral gland intersection_of: UBERON:0002530 ! gland intersection_of: RO:0003000 UBERON:0001836 ! produces saliva relationship: RO:0001025 UBERON:0000167 ! located in oral cavity relationship: RO:0002162 NCBITaxon:33213 ! in taxon Bilateria relationship: RO:0002215 GO:0046541 ! capable of saliva secretion relationship: RO:0002433 UBERON:0001007 ! contributes to morphology of digestive system relationship: RO:0003000 UBERON:0001836 ! produces saliva property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/5/51/Illu_quiz_hn_02.jpg" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001045 name: midgut def: "Middle subdivision of a digestive tract[CJM]. In vertebrates: The middle part of the alimentary canal from the stomach, or entrance of the bile duct, to, or including, the large intestine[GO]." [GO:0007494, Wikipedia:Midgut] subset: developmental_classification subset: efo_slim subset: pheno_slim subset: uberon_slim synonym: "mesenteron" RELATED OMO:0003011 [Wikipedia:Midgut] xref: BILA:0000086 xref: BTO:0000863 xref: EFO:0001950 xref: EHDAA2:0001185 xref: EHDAA:983 xref: EMAPA:16255 xref: FBbt:00005383 {sssom:mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"} xref: FMA:45617 xref: MA:0001564 xref: NCIT:C34210 xref: SCTID:361410004 xref: TGMA:0001036 xref: UMLS:C0231052 {source="ncithesaurus:Midgut"} xref: VHOG:0000290 xref: Wikipedia:Midgut xref: XAO:0000103 is_a: UBERON:0004921 ! subdivision of digestive tract relationship: proximally_connected_to UBERON:0001041 ! foregut property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/3/3d/Illu_small_intestine.jpg" xsd:anyURI property_value: IAO:0000116 "Note we define this generically to include invertebrates (partly for consistency with GO), but the class may be split in future. We may explicitly make this a developmental class" xsd:string property_value: skos:prefLabel "midgut" xsd:string [Term] id: UBERON:0001046 name: hindgut def: "The caudalmost subdivision of a digestive tract." [http://orcid.org/0000-0002-6601-2165] subset: developmental_classification subset: pheno_slim subset: uberon_slim synonym: "metenteron" RELATED OMO:0003011 [Wikipedia:Hindgut] xref: AAO:0011052 xref: BILA:0000087 xref: BTO:0000510 xref: EHDAA2:0000779 xref: EHDAA:975 xref: EMAPA:16715 xref: FBbt:00005384 {sssom:mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"} xref: FMA:45618 xref: MA:0001527 xref: NCIT:C34188 xref: SCTID:362856002 xref: TGMA:0001020 xref: UMLS:C0231053 {source="ncithesaurus:Hindgut"} xref: VHOG:0000459 xref: Wikipedia:Hindgut xref: XAO:0000104 is_a: BFO:0000002 is_a: UBERON:0004921 ! subdivision of digestive tract relationship: proximally_connected_to UBERON:0001045 ! midgut relationship: RO:0002202 UBERON:0003104 {source="Wikipedia"} ! develops from mesenchyme property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/f/f7/Gray472.png" xsd:anyURI property_value: IAO:0000116 "Note we define this generically to include invertebrates (partly for consistency with GO), but the class may be split in future (vertebrates have some contribution from NC - https://github.com/obophenotype/uberon/wiki/The-neural-crest). We may explicitly make this a developmental class" xsd:string property_value: skos:prefLabel "hindgut" xsd:string [Term] id: UBERON:0001048 name: primordium def: "Primordia are populations of contiguous cells that are morphologically distinct and already correspond in extent to a later organ/tissue[FBbt, Hartenstein, V. (2004)]." [BTO:0001886, FB:DJS, FB:FBrf0089570, http://flybase.org/reports/FBrf0178740.html] subset: efo_slim subset: pheno_slim subset: uberon_slim synonym: "bud" RELATED [] synonym: "future organ" RELATED [] synonym: "placode" RELATED [FBbt:00005495] synonym: "primordia" RELATED OMO:0003004 [XAO:0003043] synonym: "rudiment" RELATED [] xref: AEO:0000171 xref: BTO:0001886 xref: EFO:0001652 xref: EHDAA2:0003171 xref: FBbt:00005495 {sssom:mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"} xref: FMA:86589 xref: MAT:0000482 xref: NCIT:C34275 xref: UMLS:C0678727 {source="ncithesaurus:Primordium"} xref: Wikipedia:Primordium xref: XAO:0003043 is_a: UBERON:0005423 {source="EHDAA2"} ! developing anatomical structure relationship: BFO:0000050 UBERON:0000468 ! part of multicellular organism property_value: skos:prefLabel "primordium" xsd:string [Term] id: UBERON:0001049 name: neural tube def: "In the developing vertebrate, the neural tube is the embryo's precursor to the central nervous system, which comprises the brain and spinal cord. The neural groove gradually deepens as the neural folds become elevated, and ultimately the folds meet and coalesce in the middle line and convert the groove into a closed tube, the neural tube or neural canal (which strictly speaking is the center of the neural tube), the ectodermal wall of which forms the rudiment of the nervous system. [WP,unvetted]." [Wikipedia:Neural_tube] subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "neural primordium" RELATED [] synonym: "presumptive central nervous system" RELATED [] synonym: "tubus neuralis" RELATED OMO:0003011 [Wikipedia:Neural_tube] xref: AAO:0010617 xref: BTO:0001057 xref: CALOHA:TS-2371 xref: DHBA:10154 xref: EHDAA2:0001254 xref: EHDAA:2869 xref: EHDAA:908 xref: EMAPA:16164 xref: EMAPA:16757 xref: FMA:293882 xref: MAT:0000069 xref: MIAA:0000069 xref: NCIT:C34226 xref: neuronames:1365 xref: SCTID:362852000 xref: TAO:0001135 xref: UMLS:C0231024 {source="ncithesaurus:Neural_Tube"} xref: VHOG:0000307 xref: Wikipedia:Neural_tube xref: XAO:0003204 xref: ZFA:0001135 is_a: UBERON:0003914 {source="EHDAA2"} ! epithelial tube is_a: UBERON:0005291 ! embryonic tissue is_a: UBERON:0010371 ! ecto-epithelium is_a: UBERON:0016879 ! future central nervous system relationship: RO:0002202 UBERON:0005068 ! develops from neural rod property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/6/64/Gray19_with_color.png" xsd:anyURI property_value: skos:prefLabel "neural tube" xsd:string [Term] id: UBERON:0001052 name: rectum def: "The terminal portion of the intestinal tube, terminating with the anus." [http://orcid.org/0000-0002-6601-2165, ISBN:0-683-40008-8, MP:0000492] subset: efo_slim subset: human_reference_atlas subset: pheno_slim subset: uberon_slim synonym: "intestinum rectum" RELATED [BTO:0001158] synonym: "rectal sac" RELATED [] synonym: "terminal portion of intestine" EXACT [] synonym: "terminal portion of large intestine" RELATED [] xref: AAO:0010401 xref: BTO:0001158 xref: CALOHA:TS-1180 xref: EFO:0000848 xref: EHDAA2:0001592 xref: EHDAA:5836 xref: EMAPA:17896 xref: EV:0100081 xref: FMA:14544 xref: GAID:311 xref: galen:Rectum xref: MA:0000336 xref: MAT:0000050 xref: MESH:D012007 xref: MIAA:0000050 xref: NCIT:C12390 xref: SCTID:181261002 xref: UMLS:C0034896 {source="ncithesaurus:Rectum"} xref: VHOG:0001751 xref: Wikipedia:Rectum xref: XAO:0000238 is_a: UBERON:0004921 ! subdivision of digestive tract relationship: BFO:0000050 UBERON:0006866 ! part of terminal part of digestive tract relationship: BFO:0000050 UBERON:0012361 {source="EHDAA2"} ! part of internal anal region relationship: BSPO:0001108 UBERON:0000059 {source="ISBN:0073040584"} ! large intestine relationship: RO:0002150 UBERON:0001159 ! continuous with sigmoid colon relationship: RO:0002433 UBERON:0000059 ! contributes to morphology of large intestine property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/7/75/Anorectum.gif" xsd:anyURI property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/large-intestine-female/v1.3/assets/3d-sbu-f-large-intestine.glb" xsd:anyURI property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/large-intestine-male/v1.3/assets/3d-sbu-m-large-intestine.glb" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "rectum" xsd:string [Term] id: UBERON:0001054 name: Malpighian tubule def: "A tubule that extends from the posterior part of the digestive tract which absorbs solutes, water, and wastes from the surrounding hemolymph. Each tubule consists of a single layer of cells that is closed off at the distal end with the proximal end joining the alimentary canal at the junction between the midgut and hindgut[WP,modified]." [Wikipedia:Malpighian_tubule_system] comment: EDITOR_NOTE this will be ceded to the Arthropod Anatomy Ontology subset: efo_slim subset: uberon_slim synonym: "Malphigian tube" RELATED MISSPELLING [BTO:0000810] synonym: "Malpighian tube" RELATED [UBERON:cjm] synonym: "tuba Malpighii" RELATED [BTO:0000810] xref: BTO:0000810 xref: EFO:0000243 xref: FBbt:00005786 {sssom:mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"} xref: GAID:1228 xref: MAT:0000123 xref: MESH:D008317 xref: MIAA:0000123 xref: SCTID:41055008 xref: TADS:0000163 xref: TGMA:0001038 xref: Wikipedia:Malpighian_tubule is_a: UBERON:0009773 {source="GO"} ! renal tubule relationship: RO:0002162 NCBITaxon:6656 ! in taxon Arthropoda [Term] id: UBERON:0001058 name: mushroom body def: "Prominent lobed neuropils found in annelids and all arthropods except crustaceans. They are thought to be involved in olfactory associative learning and memory[MESH] Mushroom body neuropils are divided into calyces, pedunculus, and its subsequent lobes. In Drosophila these are the alpha, beta, and gamma lobes." [http://flybrain.uni-freiburg.de/Flybrain/html/terms/terms.html, MESH:A13.641, Wikipedia:Mushroom_body] subset: efo_slim subset: uberon_slim synonym: "corpora pedunculata" RELATED [FBbt:00005801, PMID:21062451] synonym: "mushroom bodies" EXACT OMO:0003004 [] xref: BTO:0002675 xref: EFO:0000925 xref: FBbt:00005801 {sssom:mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"} xref: GAID:1231 xref: MAT:0000336 xref: MESH:D024521 xref: MIAA:0000336 xref: Wikipedia:Mushroom_body is_a: BFO:0000004 is_a: UBERON:0000477 ! anatomical cluster relationship: BFO:0000050 UBERON:0000955 ! part of brain relationship: RO:0002162 NCBITaxon:33317 ! in taxon Protostomia relationship: RO:0002216 GO:0007613 {source="Wikipedia"} ! capable of part of memory relationship: RO:0002216 GO:0008355 {source="Wikipedia"} ! capable of part of olfactory learning property_value: RO:0002161 NCBITaxon:6217 property_value: RO:0002175 NCBITaxon:6340 property_value: RO:0002175 NCBITaxon:6656 [Term] id: UBERON:0001062 name: anatomical entity def: "Biological entity that is either an individual member of a biological species or constitutes the structural organization of an individual member of a biological species." [FMA:62955, http://orcid.org/0000-0001-9114-8737] subset: common_anatomy subset: upper_level xref: AAO:0010841 xref: AEO:0000000 xref: BFO:0000004 xref: BILA:0000000 xref: BIRNLEX:6 xref: CARO:0000000 xref: EHDAA2:0002229 xref: FBbt:10000000 {sssom:mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"} xref: FMA:62955 xref: HAO:0000000 xref: MA:0000001 xref: NCIT:C12219 xref: TAO:0100000 xref: TGMA:0001822 xref: UMLS:C1515976 {source="ncithesaurus:Anatomic_Structure_System_or_Substance"} xref: WBbt:0000100 xref: XAO:0000000 xref: ZFA:0100000 property_value: RO:0002175 NCBITaxon:33090 property_value: RO:0002175 NCBITaxon:33208 property_value: RO:0002175 NCBITaxon:4751 property_value: skos:prefLabel "anatomical entity" xsd:string [Term] id: UBERON:0001063 name: flocculus def: "The small lobe of the cerebellum at the posterior border of the middle cerebellar peduncle anterior to the biventer lobule that receives input from the inferior and medial vestibular nuclei and sends fibers back to the vestibular nuclei, and processes and integrates these signals to allow for the constant maintenance of balance." [http://orcid.org/0000-0002-6601-2165, ISBN:0838580343, MGI:csmith, MP:0010006, Wikipedia:Flocculus_(cerebellar)] subset: pheno_slim subset: uberon_slim synonym: "flocculus of cerebellum" EXACT [FMA:83881] synonym: "H X" RELATED [FMA:83881] synonym: "hemispheric lobule X" RELATED INCONSISTENT [NLXANAT:20081213] synonym: "lobule H X of Larsell" RELATED [FMA:83881] synonym: "lobule X" RELATED [FMA:83881] synonym: "lobule X of hemisphere of cerebellum" RELATED [FMA:83881] synonym: "neuraxis flocculus" EXACT [FMA:83881] xref: BAMS:FL xref: BAMS:Fl xref: BIRNLEX:1329 xref: DMBA:16946 xref: EMAPA:35346 xref: FMA:83881 xref: HBA:12945 xref: MA:0000992 xref: MBA:1049 xref: neuronames:680 xref: SCTID:279368002 xref: SCTID:30711003 xref: Wikipedia:Flocculus_(cerebellar) is_a: UBERON:0027331 ! flocculonodular lobe, hemisphere portion relationship: RO:0002433 UBERON:0002245 ! contributes to morphology of cerebellar hemisphere property_value: skos:prefLabel "flocculus" xsd:string [Term] id: UBERON:0001064 name: ventral pancreatic duct def: "A duct joining the pancreas to the common bile duct to supply pancreatic juices which aid in digestion provided by the exocrine pancreas. The pancreatic duct joins the common bile duct just prior to the ampulla of Vater, after which both ducts perforate the medial side of the second portion of the duodenum at the major duodenal papilla." [Wikipedia:Pancreatic_duct] comment: EDITOR_NOTE in EHDAA2 this is an epithelium, in FMA the wall consists of epithelium and connective tissue subset: human_reference_atlas subset: uberon_slim synonym: "canal of Wirsung" RELATED [BTO:0002362] synonym: "chief pancreatic duct" EXACT [FMA:16003] synonym: "duct of Wirsung" EXACT [Wikipedia:Pancreatic_duct] synonym: "ductus pancreatis ventralis" RELATED [] synonym: "hepaticopancreatic duct" RELATED [BTO:0002362] synonym: "main pancreatic duct" EXACT [MA:0000126] synonym: "pancreatic duct" BROAD [MESH:A03.734.667] xref: BTO:0002362 xref: EHDAA2:0001396 xref: EHDAA:6905 xref: EMAPA:17510 xref: FMA:16003 xref: GAID:337 xref: MA:0000126 xref: MESH:D010183 xref: NCIT:C12272 xref: RETIRED_EHDAA2:0002177 xref: SCTID:245385001 xref: UMLS:C0030288 {source="ncithesaurus:Pancreatic_Duct"} xref: VHOG:0000256 xref: Wikipedia:Pancreatic_duct is_a: UBERON:0000025 ! tube is_a: UBERON:0007329 {source="FMA"} ! pancreatic duct relationship: channel_for UBERON:0001970 ! bile relationship: channels_into UBERON:0004913 ! hepatopancreatic ampulla relationship: RO:0002150 UBERON:0001174 ! continuous with common bile duct relationship: RO:0002202 UBERON:0003924 {source="EHDAA2"} ! develops from ventral pancreatic bud property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/1/15/Gray1100.png" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "ventral pancreatic duct" xsd:string [Term] id: UBERON:0001066 name: intervertebral disk def: "A pad of fibrocartilage between the articular surfaces of two successive vertebral centra which has nucleus pulposus at its core." [ISBN:0073040584, Wikipedia:Intervertebral_disk] comment: whose gel-like core is nucleus puloposus, by this definition only in mammals subset: efo_slim subset: pheno_slim subset: uberon_slim synonym: "discus intervertebralis" EXACT OMO:0003011 [FMA:10446, FMA:TA] synonym: "intervertebral disc" EXACT [] synonym: "intervertebral fibrocartilage" RELATED [BTO:0003625] synonym: "spinal disc" EXACT [Wikipedia:Spinal_disc] synonym: "spinal disk" RELATED [BTO:0003625] xref: BTO:0003625 xref: EFO:0001370 xref: EMAPA:32739 xref: FMA:10446 xref: GAID:105 xref: MA:0000110 xref: MESH:D007403 xref: NCIT:C49571 xref: SCTID:244570000 xref: UMLS:C0021815 {source="ncithesaurus:Intervertebral_Disc"} xref: Wikipedia:Intervertebral_disk is_a: UBERON:0011135 ! intervertebral cartilage intersection_of: UBERON:0011135 ! intervertebral cartilage intersection_of: BFO:0000051 UBERON:0002242 ! has part nucleus pulposus relationship: BFO:0000051 UBERON:0002242 ! has part nucleus pulposus property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/9/92/Gray301.png" xsd:anyURI [Term] id: UBERON:0001068 name: skin of back def: "A zone of skin that is part of a back [Automatically generated definition]." [OBOL:automatic] comment: EDITOR_NOTE TODO - distinguish between entire skin of region and arbitrary zone of skin on region subset: pheno_slim synonym: "back skin" EXACT [] synonym: "back zone of skin" EXACT [OBOL:automatic] synonym: "skin, dorsal region" EXACT [https://orcid.org/0000-0002-6601-2165] synonym: "zone of skin of back" EXACT [OBOL:automatic] xref: EMAPA:36392 xref: FMA:10462 xref: FMA:22985 xref: MA:0000498 xref: SCTID:181492002 is_a: UBERON:0001085 {source="MA"} ! skin of trunk intersection_of: UBERON:0000014 ! zone of skin intersection_of: BFO:0000050 UBERON:0001137 ! part of dorsum relationship: BFO:0000050 UBERON:0011270 {source="MA"} ! part of dorsal trunk property_value: skos:prefLabel "skin of back" xsd:string [Term] id: UBERON:0001070 name: external carotid artery def: "A terminal branch of the left or right common carotid artery which supplies oxygenated blood to to the throat, neck glands, tongue, face, mouth, ear, scalp and dura mater of the meninges[MP]." [MGI:anna] subset: efo_slim subset: human_reference_atlas subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "arteria carotis externa" RELATED OMO:0003011 [Wikipedia:External_carotid_artery] synonym: "external carotid" EXACT [AAO:0010218] xref: AAO:0010218 xref: AAO:0010416 xref: BTO:0004696 xref: EFO:0001953 xref: EHDAA2:0000461 xref: EMAPA:18611 xref: FMA:10635 xref: GAID:480 xref: MA:0001929 xref: MESH:D002342 xref: NCIT:C32551 xref: SCTID:362044002 xref: UMLS:C0007275 {source="ncithesaurus:External_Carotid_Artery"} xref: VHOG:0000265 xref: Wikipedia:External_carotid_artery xref: XAO:0000345 is_a: UBERON:0005396 {source="MA"} ! carotid artery segment relationship: RO:0002202 UBERON:0001530 {source="EHDAA2"} ! develops from common carotid artery plus branches relationship: RO:0002380 UBERON:0001530 {source="FMA"} ! branching part of common carotid artery plus branches property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/1/13/External_carotid_a.gif" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 property_value: seeAlso "https://sourceforge.net/tracker/?func=detail&aid=3486863&group_id=76834&atid=1127722" xsd:anyURI property_value: skos:prefLabel "external carotid artery" xsd:string [Term] id: UBERON:0001071 name: superficial cervical artery def: "It ascends beneath the anterior margin of the trapezius, distributing branches to it, and to the neighboring muscles and lymph glands in the neck, and anastomosing with the superficial branch of the descending branch of the occipital artery." [Wikipedia:Superficial_part_of_transverse_cervical_artery] comment: The transverse cervical artery splits into two branches, a superficial one and a deep one[WP] subset: human_reference_atlas subset: uberon_slim synonym: "superficial branch of transverse cervical artery" EXACT [Wikipedia:Superficial_part_of_transverse_cervical_artery] xref: EMAPA:37117 {source="MA:th"} xref: FMA:10665 xref: MA:0002052 xref: NCIT:C53005 xref: SCTID:161746006 xref: UMLS:C0226271 {source="ncithesaurus:Superficial_Cervical_Artery"} xref: Wikipedia:Superficial_part_of_transverse_cervical_artery is_a: UBERON:0012320 ! cervical artery intersection_of: UBERON:0012320 ! cervical artery intersection_of: BFO:0000050 UBERON:0035549 ! part of vasculature of integument relationship: BFO:0000050 UBERON:0035549 ! part of vasculature of integument relationship: RO:0002170 UBERON:0012324 ! connected to transverse cervical artery property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "superficial cervical artery" xsd:string [Term] id: UBERON:0001072 name: inferior vena cava def: "A vein that carries deoxygenated blood from the lower half of the body into the right atrium of the heart." [http://orcid.org/0000-0002-6601-2165, Wikipedia:Inferior_vena_cava] subset: human_reference_atlas subset: pheno_slim subset: uberon_slim synonym: "caudal vena cava" RELATED [VHOG:0001194] synonym: "inferior caval vein" EXACT [http://orcid.org/0000-0002-6601-2165] synonym: "postcava" RELATED [] synonym: "posterior vena cava" EXACT [PMID:21154280] synonym: "vena cava inferior" RELATED OMO:0003011 [BTO:0002682, Wikipedia:Inferior_vena_cava] xref: AAO:0011083 xref: BTO:0002682 xref: EHDAA2:0000611 xref: EMAPA:18416 xref: FMA:10951 xref: GAID:548 xref: galen:InferiorVenaCava xref: MA:0000480 xref: MESH:D014682 xref: NCIT:C12815 xref: SCTID:181369003 xref: UMLS:C0042458 {source="ncithesaurus:Inferior_Vena_Cava"} xref: VHOG:0001194 xref: Wikipedia:Inferior_vena_cava xref: XAO:0000388 is_a: UBERON:0004087 ! vena cava intersection_of: UBERON:0004087 ! vena cava intersection_of: RO:0020102 UBERON:0000154 ! vessel drains blood from posterior region of body disjoint_from: UBERON:0001585 {source="lexical"} ! anterior vena cava relationship: RO:0002170 UBERON:0002078 ! connected to right cardiac atrium relationship: RO:0020102 UBERON:0000154 ! vessel drains blood from posterior region of body property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/4/4d/Gray577.png" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "inferior vena cava" xsd:string [Term] id: UBERON:0001073 name: ileocecal junction def: "A point along the course of the gastrointestinal tract where the small intestine (ileum) ends as it opens into the cecal portion of the large intestine; occurs usually within the iliac fossa, demarcated internally as the ileocecal orifice." [http://www.medilexicon.com/medicaldictionary.php?t=46539] synonym: "ileocaecal junction" EXACT [] xref: EMAPA:37601 {source="MA:th"} xref: FMA:11338 xref: MA:0000332 xref: SCTID:264021000 is_a: UBERON:8410024 ! intestinal junction intersection_of: UBERON:0007651 ! anatomical junction intersection_of: RO:0002176 UBERON:0000059 ! connects large intestine intersection_of: RO:0002176 UBERON:0002108 ! connects small intestine relationship: RO:0002176 UBERON:0000059 ! connects large intestine relationship: RO:0002176 UBERON:0002108 ! connects small intestine property_value: skos:prefLabel "ileocecal junction" xsd:string [Term] id: UBERON:0001074 name: pericardial cavity def: "A potential space between the visceral and parietal layers of the pericardium." [Wikipedia:Pericardium] subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "cavitas pericardiaca" RELATED OMO:0003011 [Wikipedia:Pericardial_cavity] synonym: "cavity of pericardial sac" EXACT [] synonym: "pericardial space" EXACT [Wikipedia:Pericardial_cavity] xref: BSA:0000091 xref: EHDAA2:0001434 xref: EMAPA:16131 xref: EMAPA:16132 xref: FMA:11350 xref: galen:PericardialSpace xref: MA:0000053 xref: NCIT:C38662 xref: SCTID:362027001 xref: TAO:0002220 xref: UMLS:C0225972 {source="ncithesaurus:Pericardial_Cavity"} xref: VHOG:0000556 xref: Wikipedia:Pericardial_cavity xref: ZFA:0001655 is_a: UBERON:0002323 {source="MA"} ! coelemic cavity lumen is_a: UBERON:0035809 ! serous cavity intersection_of: UBERON:0002553 ! anatomical cavity intersection_of: RO:0002572 UBERON:0002406 ! luminal space of pericardial sac relationship: RO:0001015 UBERON:0002409 ! location of pericardial fluid relationship: RO:0002202 UBERON:0003887 {source="Wikipedia"} ! develops from intraembryonic coelom relationship: RO:0002219 UBERON:0002357 ! surrounded by serous pericardium relationship: RO:0002572 UBERON:0002406 ! luminal space of pericardial sac property_value: skos:prefLabel "pericardial cavity" xsd:string [Term] id: UBERON:0001075 name: bony vertebral centrum def: "Ossified form of a vertebral centrum, a skeletal element that functionally replaces the notochord[VSAP,modified]." [http://orcid.org/0000-0002-6601-2165, VSAO:0000183, VSAO:curator] subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "arcocentrum" NARROW INCONSISTENT [PMID:11746457] synonym: "autocentrum" NARROW [PMID:11746457, ZFA:0000126] synonym: "body of vertebra" EXACT [FMA:11945] synonym: "centra" RELATED OMO:0003004 [PHENOSCAPE:ad] synonym: "corpus vertebra" EXACT OMO:0003011 [] synonym: "corpus vertebrae" RELATED OMO:0003004 [Wikipedia:Body_of_vertebra] synonym: "corpus vertebrae (vertebrale)" EXACT [FMA:11945] synonym: "holocentrum" NARROW [PMID:11746457] synonym: "vertebral body" EXACT [FMA:11945] synonym: "vertebral centra" RELATED OMO:0003004 [PHENOSCAPE:ad] synonym: "vertebral centrum" RELATED [MA:0001457] xref: AAO:0000697 xref: EMAPA:36588 xref: FMA:11945 xref: MA:0001457 xref: NCIT:C12852 xref: SCTID:361745008 xref: SCTID:362867001 xref: TAO:0000126 xref: UMLS:C0223084 {source="ncithesaurus:Vertebral_Body"} xref: Wikipedia:Body_of_vertebra xref: ZFA:0000126 is_a: UBERON:0001474 ! bone element is_a: UBERON:0016491 ! vertebral centrum element intersection_of: UBERON:0016491 ! vertebral centrum element intersection_of: RO:0002473 UBERON:0002481 ! composed primarily of bone tissue relationship: BFO:0000050 UBERON:0002412 ! part of vertebra property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/6/63/Corpusvertebrae.png" xsd:anyURI [Term] id: UBERON:0001076 name: neural spine def: "An extension of a neural arches dorsal to the neural canal[TAO,modified]." [http://orcid.org/0000-0002-6601-2165, TAO:0001336] subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "neural spine" RELATED [] synonym: "neural spines" RELATED OMO:0003004 [ZFA:0001336] synonym: "processus spinosus" EXACT [] synonym: "processus spinosus vertebrae" EXACT [] synonym: "spine of verterba" RELATED [FMA:11948] synonym: "spinous process" BROAD [] synonym: "spinous process of vertebra" EXACT HUMAN_PREFERRED [FMA:11948] synonym: "vertebra spinous process" EXACT [MA:0001455] xref: AAO:0000705 xref: EMAPA:25107 xref: FMA:11948 xref: MA:0001455 xref: NCIT:C116112 xref: SCTID:264259004 xref: TAO:0001336 xref: Wikipedia:Spinous_process xref: ZFA:0001336 is_a: UBERON:0006061 ! process of vertebra relationship: BFO:0000050 UBERON:0003861 ! part of neural arch property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/4/48/Processusspinosusvertebrae.png" xsd:anyURI [Term] id: UBERON:0001077 name: transverse process of vertebra def: "The transverse or costal processes of a vertebra, two in number, project one at either side from the point where the lamina joins the pedicle, between the superior and inferior articular processes. They serve for the attachment of muscles and ligaments. [WP,unvetted]." [Wikipedia:Transverse_process] subset: pheno_slim subset: uberon_slim synonym: "diapophyses" RELATED [] synonym: "diapophysis" RELATED [] synonym: "processus transversus" EXACT [] synonym: "processus transversus vertebrae" EXACT [] synonym: "transverse process" EXACT [] synonym: "vertebra transverse process" EXACT [] xref: AAO:0000698 xref: FMA:11949 xref: MA:0001456 xref: SCTID:264238006 xref: Wikipedia:Transverse_process xref: XAO:0003102 is_a: UBERON:0006061 ! process of vertebra property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/a/a1/Processustransversusvertebrae.PNG" xsd:anyURI [Term] id: UBERON:0001081 name: endocardium of ventricle def: "Endocardium that is part of the cardiac ventricle." [ZFIN:curator] subset: pheno_slim subset: vertebrate_core synonym: "cardiac ventricle endocardium" EXACT [OBOL:automatic] synonym: "endocardium of cardiac ventricle" EXACT [OBOL:automatic] synonym: "endocardium of heart ventricle" EXACT [OBOL:automatic] synonym: "endocardium of lower chamber of heart" EXACT [OBOL:automatic] synonym: "endocardium of ventricle of heart" EXACT [OBOL:automatic] synonym: "heart ventricle endocardium" EXACT [OBOL:automatic] synonym: "lower chamber of heart endocardium" EXACT [OBOL:automatic] synonym: "ventricle endocardial tissue" RELATED [VHOG:0000607] synonym: "ventricle endocardium" EXACT [] synonym: "ventricle of heart endocardium" EXACT [OBOL:automatic] synonym: "ventricular endocardium" EXACT [] xref: EMAPA:32747 xref: FMA:12148 xref: MA:0000079 xref: SCTID:192172004 xref: TAO:0002247 xref: VHOG:0000607 xref: ZFA:0001615 is_a: UBERON:0002165 ! endocardium intersection_of: UBERON:0002165 ! endocardium intersection_of: BFO:0000050 UBERON:0002082 ! part of cardiac ventricle relationship: BFO:0000050 UBERON:0004784 {source="https://github.com/obophenotype/uberon/wiki/Inferring-part-of-relationships"} ! part of heart ventricle wall relationship: RO:0002433 UBERON:0002082 ! contributes to morphology of cardiac ventricle property_value: skos:prefLabel "endocardium of ventricle" xsd:string [Term] id: UBERON:0001082 name: epicardium of ventricle def: "An epicardial layer that lines a cardiac ventricle." [http://orcid.org/0000-0002-6601-2165] subset: vertebrate_core synonym: "cardiac ventricle epicardium" EXACT [OBOL:automatic] synonym: "ventricular epicardium" EXACT [] xref: FMA:12150 xref: TAO:0005058 xref: ZFA:0005058 is_a: UBERON:0002348 ! epicardium intersection_of: UBERON:0002348 ! epicardium intersection_of: BFO:0000050 UBERON:0002082 ! part of cardiac ventricle relationship: BFO:0000050 UBERON:0002082 ! part of cardiac ventricle property_value: skos:prefLabel "epicardium of ventricle" xsd:string [Term] id: UBERON:0001083 name: myocardium of ventricle def: "Muscular layer of the cardiac ventricle composed of a compact myocardial layer surrounding the trabecular layer." [ZFIN:curator] subset: efo_slim subset: pheno_slim subset: vertebrate_core synonym: "ventricle cardiac muscle" RELATED [VHOG:0000604] synonym: "ventricle myocardium" EXACT [] synonym: "ventricular myocardium" EXACT [] xref: EFO:0003088 xref: EMAPA:32748 xref: FMA:12151 xref: MA:0000082 xref: SCTID:192084000 xref: TAO:0005061 xref: VHOG:0000604 xref: ZFA:0005061 is_a: UBERON:0002349 ! myocardium intersection_of: UBERON:0002349 ! myocardium intersection_of: BFO:0000050 UBERON:0002082 ! part of cardiac ventricle relationship: BFO:0000050 UBERON:0004784 {source="https://github.com/obophenotype/uberon/wiki/Inferring-part-of-relationships"} ! part of heart ventricle wall relationship: RO:0002433 UBERON:0002082 ! contributes to morphology of cardiac ventricle property_value: skos:prefLabel "myocardium of ventricle" xsd:string [Term] id: UBERON:0001084 name: skin of head def: "A zone of skin that is part of a head [Automatically generated definition]." [OBOL:automatic] comment: EDITOR_NOTE TODO - distinguish between entire skin of region and arbitrary zone of skin on region synonym: "adult head zone of skin" EXACT [OBOL:automatic] synonym: "head skin" EXACT [] synonym: "head zone of skin" EXACT [OBOL:automatic] synonym: "zone of skin of adult head" EXACT [OBOL:automatic] synonym: "zone of skin of head" EXACT [OBOL:automatic] xref: FMA:12166 xref: FMA:24756 xref: MA:0000582 xref: NCIT:C52757 xref: SCTID:181484006 xref: UMLS:C0205029 {source="ncithesaurus:Head_Skin"} is_a: UBERON:0012180 ! head or neck skin intersection_of: UBERON:0000014 ! zone of skin intersection_of: BFO:0000050 UBERON:0000033 ! part of head relationship: BFO:0000050 UBERON:0000033 ! part of head property_value: skos:prefLabel "skin of head" xsd:string [Term] id: UBERON:0001085 name: skin of trunk def: "A zone of skin that is part of a trunk [Automatically generated definition]." [OBOL:automatic] comment: EDITOR_NOTE TODO - distinguish between entire skin of region and arbitrary zone of skin on region synonym: "torso zone of skin" EXACT [OBOL:automatic] synonym: "trunk skin" EXACT [] synonym: "trunk zone of skin" EXACT [OBOL:automatic] synonym: "zone of skin of torso" EXACT [OBOL:automatic] synonym: "zone of skin of trunk" EXACT [OBOL:automatic] xref: EMAPA:37278 {source="MA:th"} xref: FMA:12167 xref: FMA:23093 xref: MA:0000517 xref: NCIT:C12295 xref: SCTID:181489001 xref: UMLS:C0205031 {source="ncithesaurus:Skin_of_the_Trunk"} is_a: UBERON:0000014 ! zone of skin intersection_of: UBERON:0000014 ! zone of skin intersection_of: BFO:0000050 UBERON:0002100 ! part of trunk relationship: BFO:0000050 UBERON:0002100 ! part of trunk property_value: skos:prefLabel "skin of trunk" xsd:string [Term] id: UBERON:0001087 name: pleural fluid def: "Transudate contained in the pleural cavity." [FMA:12273] subset: uberon_slim xref: BTO:0003080 xref: FMA:12273 xref: MA:0002532 xref: MAT:0000500 xref: ncithesaurus:Pleural_Fluid xref: Wikipedia:Pleural_fluid is_a: UBERON:0036244 ! secretion of serous membrane intersection_of: UBERON:0007779 ! transudate intersection_of: RO:0001025 UBERON:0002402 ! located in pleural cavity relationship: RO:0001025 UBERON:0002402 ! located in pleural cavity property_value: skos:prefLabel "pleural fluid" xsd:string [Term] id: UBERON:0001088 name: urine def: "Excretion that is the output of a kidney." [https://github.com/geneontology/go-ontology/issues/11025, Wikipedia:Urine] subset: efo_slim subset: pheno_slim subset: uberon_slim xref: BTO:0001419 xref: CALOHA:TS-1092 xref: EFO:0001939 xref: EMAPA:36554 xref: ENVO:00002047 xref: FMA:12274 xref: GAID:1189 xref: galen:Urine xref: MA:0002545 xref: MAT:0000058 xref: MESH:D014556 xref: MIAA:0000058 xref: NCIT:C13283 xref: UMLS:C0042036 {source="ncithesaurus:Urine"} xref: Wikipedia:Urine is_a: UBERON:0000174 ! excreta intersection_of: UBERON:0000174 ! excreta intersection_of: RO:0003001 UBERON:0002113 ! produced by kidney relationship: RO:0003001 UBERON:0002113 ! produced by kidney [Term] id: UBERON:0001089 name: sweat def: "Secretion produced by a sweat gland." [FMA:12275] subset: pheno_slim subset: uberon_slim synonym: "skin exudate" RELATED [BTO:0001254] xref: BTO:0001254 xref: ENVO:02000025 xref: FMA:12275 xref: GAID:1172 xref: MA:0002539 xref: MESH:D013542 xref: NCIT:C13280 xref: UMLS:C0038984 {source="ncithesaurus:Sweat"} xref: Wikipedia:Sweat is_a: UBERON:0000456 ! secretion of exocrine gland is_a: UBERON:0006314 ! bodily fluid intersection_of: UBERON:0000456 ! secretion of exocrine gland intersection_of: RO:0003001 UBERON:0001820 ! produced by sweat gland relationship: RO:0003001 UBERON:0001820 ! produced by sweat gland [Term] id: UBERON:0001090 name: synovial fluid def: "Joint fluid is a transudate of plasma that is actively secreted by synovial cells." [https://www.ncbi.nlm.nih.gov/books/NBK274/] subset: uberon_slim subset: vertebrate_core synonym: "joint fluid" EXACT [https://www.ncbi.nlm.nih.gov/books/NBK274/] xref: BTO:0001339 xref: CALOHA:TS-0996 xref: ENVO:02000039 xref: FMA:12277 xref: GAID:265 xref: galen:SynovialFluid xref: MA:0002544 xref: MESH:D013582 xref: NCIT:C33718 xref: TAO:0005154 xref: UMLS:C0039097 {source="ncithesaurus:Synovial_Fluid"} xref: Wikipedia:Synovial_fluid xref: ZFA:0005154 is_a: UBERON:0007779 ! transudate is_a: UBERON:0007794 {source="FMA"} ! secretion of serous gland intersection_of: UBERON:0007779 ! transudate intersection_of: RO:0003001 CL:0000214 ! produced by synovial cell relationship: BFO:0000051 CHEBI:16336 ! has part relationship: RO:0001025 UBERON:0007617 ! located in synovial cavity of joint relationship: RO:0003001 CL:0000214 ! produced by synovial cell property_value: skos:prefLabel "synovial fluid" xsd:string [Term] id: UBERON:0001091 name: calcareous tooth def: "Skeletal element within the mouth (or in some species, upper part of the digestive tract) that is composed of dentine and is used in procuring or masticating food." [http://orcid.org/0000-0002-6601-2165, Wikipedia:Tooth_(animal)] comment: EDITOR_NOTE we place ZFA ctb 5 tooth here for now. Consider changing name from calcaeeous tooth. Note that sea cucumbers develop calcareous tooth-like structures subset: efo_slim subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "dental element" EXACT [http://orcid.org/0000-0002-6601-2165] synonym: "dentine containing tooth" EXACT [] synonym: "tooth" EXACT [] synonym: "vertebrate tooth" EXACT [] xref: AEO:0000220 xref: BTO:0000397 xref: CALOHA:TS-1055 xref: EFO:0000839 xref: EHDAA2:0004605 xref: EMAPA:32906 xref: EV:0100063 xref: FMA:12516 xref: GAID:1260 xref: MA:0000348 xref: MAT:0000041 xref: MESH:D014070 xref: MIAA:0000041 xref: NCIT:C12506 xref: SCTID:302214001 xref: TAO:0001625 xref: UMLS:C0040426 {source="ncithesaurus:Tooth"} xref: VHOG:0001733 xref: Wikipedia:Tooth xref: XAO:0000431 is_a: UBERON:0003913 ! tooth-like structure is_a: UBERON:0010314 ! structure with developmental contribution from neural crest relationship: BFO:0000051 UBERON:0001751 ! has part dentine relationship: RO:0002254 UBERON:0000930 {source="XAO-modified"} ! has developmental contribution from stomodeum relationship: RO:0002254 UBERON:0005176 {source="ZFA-modified"} ! has developmental contribution from tooth enamel organ relationship: RO:0002495 UBERON:0008281 {source="cjm"} ! immediate transformation of tooth bud property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/1/14/Teeth_by_David_Shankbone.jpg" xsd:anyURI property_value: RO:0002161 NCBITaxon:189497 {source="Wikipedia"} property_value: RO:0002161 NCBITaxon:8782 property_value: RO:0002161 NCBITaxon:9257 {source="PMID:10210685"} property_value: RO:0002161 NCBITaxon:9761 [Term] id: UBERON:0001092 name: vertebral bone 1 def: "The first vertebral bone in the vertebral column." [http://orcid.org/0000-0002-6601-2165] subset: human_reference_atlas subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "atlas" EXACT [] synonym: "atlas (CI)" EXACT [] synonym: "atlas [C I]" EXACT OMO:0003011 [FMA:12519, FMA:TA] synonym: "atlas vertebra" EXACT [] synonym: "C1" BROAD [] synonym: "C1 vertebra" EXACT [] synonym: "cervical atlas" EXACT [MP:0011576] synonym: "cervical vertebra 1" EXACT HUMAN_PREFERRED [MA:0001421] synonym: "first cervical vertebra" EXACT [] synonym: "vertebra 1" EXACT [TAO:0001167] xref: AAO:0000709 xref: EHDAA:10606 xref: EMAPA:19431 xref: FMA:12519 xref: GAID:236 xref: MA:0001421 xref: MESH:D001270 xref: NCIT:C32239 xref: SCTID:181818007 xref: TAO:0001167 xref: UMLS:C0004170 {source="ncithesaurus:C1_Vertebra"} xref: Wikipedia:Atlas_(anatomy) xref: ZFA:0001167 is_a: UBERON:0002412 ! vertebra relationship: BSPO:0000096 UBERON:0001093 ! vertebral bone 2 property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "vertebral bone 1" xsd:string [Term] id: UBERON:0001093 name: vertebral bone 2 def: "The second vertebral bone in the vertebral column." [http://orcid.org/0000-0002-6601-2165] subset: human_reference_atlas subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "axis" RELATED INCONSISTENT [MA:0001422] synonym: "axis (CII)" EXACT [] synonym: "axis [C II]" EXACT OMO:0003011 [FMA:12520, FMA:TA] synonym: "axis vertebra" EXACT [] synonym: "C2" RELATED [] synonym: "C2 vertebra" NARROW [] synonym: "cervical axis" EXACT [MP:0004608] synonym: "cervical vertebra 2" NARROW HUMAN_PREFERRED [MA:0001422] synonym: "second cervical vertebra" NARROW [] synonym: "vertebra 2" EXACT [ZFA:0001168] xref: EHDAA:10608 xref: EMAPA:19432 xref: FMA:12520 xref: GAID:237 xref: MA:0001422 xref: MESH:D001368 xref: NCIT:C32240 xref: SCTID:181819004 xref: TAO:0001168 xref: UMLS:C0004457 {source="ncithesaurus:C2_Vertebra"} xref: Wikipedia:Axis_(anatomy) xref: ZFA:0001168 is_a: UBERON:0002412 ! vertebra relationship: anteriorly_connected_to UBERON:0001092 {source="FMA"} ! vertebral bone 1 property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "vertebral bone 2" xsd:string [Term] id: UBERON:0001094 name: sacral vertebra def: "A vertebra bone that is part of the sacral region of the vertebral column." [http://orcid.org/0000-0002-6601-2165] comment: EDITOR_NOTE todo - AAO placement to be confirmed by AAO curators (the AAO class may also include modified ribs) subset: human_reference_atlas subset: pheno_slim subset: uberon_slim synonym: "sacral segment" EXACT [] synonym: "segment of sacrum" EXACT [] xref: AAO:0000552 xref: EMAPA:18336 xref: FMA:12526 xref: galen:SacralVertebra xref: MA:0000313 xref: NCIT:C12853 xref: neuronames:1706 xref: SCTID:361773005 xref: UMLS:C1261045 {source="ncithesaurus:Sacral_Vertebra"} xref: Wikipedia:Sacrum xref: XAO:0003078 is_a: UBERON:0002412 ! vertebra is_a: UBERON:0003828 ! abdominal segment bone is_a: UBERON:0004247 ! bone of dorsum is_a: UBERON:0015010 ! sacral vertebra endochondral element intersection_of: UBERON:0015010 ! sacral vertebra endochondral element intersection_of: RO:0002473 UBERON:0002481 ! composed primarily of bone tissue relationship: RO:0002202 UBERON:0010745 ! develops from sacral vertebra cartilage element property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001095 name: caudal vertebra def: "Any vertebral bone that is part of the caudal region of the vertebral column (tail or coccyx)." [http://orcid.org/0000-0002-6601-2165] comment: Taxon notes In zebrafish, Vertebra bearing a hemal arch and spine. The most posterior caudal vertebrae support the caudal fin and are referred to as preural vertebrae subset: human_reference_atlas subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "caudal vertebra" BROAD SENSU [FMA:12527] synonym: "caudal vertebrae" EXACT OMO:0003004 [] synonym: "caudal vertebral bone" EXACT [] synonym: "caudal vertebral bone element" EXACT [] synonym: "coccygea" RELATED [MA:0001420] synonym: "coccygeal segment" EXACT [] synonym: "coccygeal vertebra" EXACT [FMA:12527] synonym: "fused tail vertebra" EXACT [https://orcid.org/0000-0002-6601-2165] synonym: "tail vertebra" RELATED [MA:0000310] xref: EMAPA:18374 xref: FMA:12527 xref: galen:CoccygealVertebra xref: MA:0000310 xref: MA:0001420 xref: NCIT:C32334 xref: SCTID:361774004 xref: TAO:0000326 xref: UMLS:C0223616 {source="ncithesaurus:Coccygeal_Vertebra"} xref: Wikipedia:Caudal_vertebra xref: XAO:0003079 xref: ZFA:0000326 is_a: UBERON:0002412 ! vertebra is_a: UBERON:0004247 ! bone of dorsum is_a: UBERON:0018142 ! caudal vertebra endochondral element intersection_of: UBERON:0018142 ! caudal vertebra endochondral element intersection_of: RO:0002473 UBERON:0002481 ! composed primarily of bone tissue property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "caudal vertebra" xsd:string [Term] id: UBERON:0001096 name: wall of esophagus def: "An anatomical wall that is part of a esophagus [Automatically generated definition]." [OBOL:automatic] synonym: "anatomical wall of esophagus" EXACT [OBOL:automatic] synonym: "anatomical wall of gullet" EXACT [OBOL:automatic] synonym: "anatomical wall of oesophagus" EXACT [OBOL:automatic] synonym: "esophageal wall" EXACT [] synonym: "esophagus anatomical wall" EXACT [OBOL:automatic] synonym: "esophagus wall" EXACT [] synonym: "gullet anatomical wall" EXACT [OBOL:automatic] synonym: "gullet wall" EXACT [OBOL:automatic] synonym: "oesophagus anatomical wall" EXACT [OBOL:automatic] synonym: "oesophagus wall" EXACT [OBOL:automatic] synonym: "wall of gullet" EXACT [OBOL:automatic] synonym: "wall of oesophagus" EXACT [OBOL:automatic] xref: EMAPA:35326 xref: FMA:12611 xref: MA:0002691 is_a: UBERON:0000328 ! gut wall intersection_of: UBERON:0000060 ! anatomical wall intersection_of: BFO:0000050 UBERON:0001043 ! part of esophagus relationship: BFO:0000050 UBERON:0001043 ! part of esophagus property_value: skos:prefLabel "wall of esophagus" xsd:string [Term] id: UBERON:0001100 name: pectoralis minor def: "The Pectoralis minor is a thin, triangular muscle, situated at the upper part of the chest, beneath the Pectoralis major. [WP,unvetted]." [Wikipedia:Pectoralis_minor_muscle] subset: human_reference_atlas subset: organ_slim subset: pheno_slim subset: uberon_slim synonym: "musculus pectoralis minor" RELATED OMO:0003011 [Wikipedia:Pectoralis_minor_muscle] synonym: "pectoralis minor muscle" EXACT [] synonym: "supracoracoideus" NARROW SENSU [] synonym: "supracoracoideus muscle" NARROW SENSU [] xref: EHDAA2:0001425 xref: EHDAA:8313 xref: EMAPA:18180 xref: FMA:13109 xref: MA:0002355 xref: NCIT:C33285 xref: SCTID:181625002 xref: UMLS:C0224347 {source="ncithesaurus:Pectoralis_Minor"} xref: VHOG:0000902 xref: Wikipedia:Pectoralis_minor_muscle is_a: UBERON:0001495 {source="FMA"} ! pectoral muscle relationship: RO:0002372 UBERON:0002228 ! has muscle origin rib relationship: RO:0002373 UBERON:0007174 ! has muscle insertion medial border of scapula property_value: foaf:depiction "https://upload.wikimedia.org/wikipedia/commons/5/5d/Pectoralis_minor.png" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001103 name: diaphragm def: "A thin musculomebranous barrier that separates the abdominal and thoracic cavities. Often used for breathing control." [MP:0002279] subset: efo_slim subset: organ_slim subset: pheno_slim subset: uberon_slim synonym: "diaphragm muscle" EXACT [BTO:0000341] synonym: "diaphragm of thorax" EXACT [] synonym: "midriff" RELATED [BTO:0000341] synonym: "phren" RELATED [BTO:0000341] synonym: "thoracic diaphragm" EXACT [] xref: BTO:0000341 xref: CALOHA:TS-0198 xref: EFO:0000937 xref: EHDAA2:0003495 xref: EMAPA:17701 xref: EV:0100376 xref: FMA:13295 xref: GAID:158 xref: MA:0001904 xref: MAT:0000502 xref: MESH:D003964 xref: NCIT:C12702 xref: SCTID:181614006 xref: UMLS:C0011980 {source="ncithesaurus:Diaphragm"} xref: VHOG:0000713 xref: Wikipedia:Thoracid_diaphragm is_a: UBERON:0003830 ! thoracic segment muscle is_a: UBERON:0003831 ! respiratory system muscle relationship: RO:0002005 UBERON:0001884 ! innervated by phrenic nerve relationship: RO:0002495 UBERON:0010084 {evidence="definitional"} ! immediate transformation of future diaphragm property_value: RO:0002161 NCBITaxon:8782 {source="Wikipedia:Thoracic_diaphragm#Comparative_anatomy_and_evolution"} property_value: skos:prefLabel "diaphragm" xsd:string [Term] id: UBERON:0001105 name: clavicle bone def: "A paired dermal or endochondral bone that is part of the pectoral girdle. The clavicle may be in contact with the interclavicle or coracoid and forms an attachment site for pectoral musculature. [PHENOSCAPE:ad]." [https://github.com/obophenotype/uberon/issues/103, PHENOSCAPE:ad] subset: human_reference_atlas subset: pheno_slim subset: uberon_slim synonym: "clavicle" EXACT [VSAO:0005031] synonym: "clavicula" EXACT [VSAO:0005031] synonym: "collar bone" EXACT [] synonym: "collarbone" EXACT [] xref: AAO:0000761 xref: EMAPA:18721 xref: FMA:13321 xref: GAID:182 xref: galen:Clavicle xref: MA:0001329 xref: MESH:D002968 xref: MFMO:0000047 xref: NCIT:C12695 xref: SCTID:181910004 xref: UMLS:C0008913 {source="ncithesaurus:Clavicle"} xref: VHOG:0000849 xref: VSAO:0005031 xref: Wikipedia:Clavicle is_a: UBERON:0002495 {source="FMA"} ! long bone is_a: UBERON:0007829 ! pectoral girdle bone is_a: UBERON:0015212 ! lateral structure relationship: BSPO:0000126 UBERON:0002091 ! appendicular skeleton relationship: RO:0002202 UBERON:0010905 ! develops from clavicle bone primordium relationship: RO:0002254 UBERON:0010843 ! has developmental contribution from clavicle cartilage element property_value: foaf:depiction "https://upload.wikimedia.org/wikipedia/commons/5/59/Pectoral_girdles-en.svg" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 property_value: terms:contributor https://orcid.org/0000-0001-9114-8737 property_value: terms:contributor https://orcid.org/0000-0002-6601-2165 [Term] id: UBERON:0001112 name: latissimus dorsi muscle def: "The latissimus dorsi is the larger, flat, dorso-lateral muscle on the trunk, posterior to the arm, and partly covered by the trapezius on its median dorsal region. [WP,unvetted]." [Wikipedia:Latissimus_dorsi_muscle] comment: Dorsal group[Kardong] subset: efo_slim subset: human_reference_atlas subset: pheno_slim subset: uberon_slim synonym: "dorsal latissimus muscle" EXACT [] synonym: "latissimi dorsi" EXACT OMO:0003004 [] synonym: "latissimus dorsi" EXACT [] synonym: "musculus latissimus dorsi" EXACT [] synonym: "musculus latissimus dorsi" RELATED OMO:0003011 [Wikipedia:Latissimus_dorsi_muscle] xref: EFO:0003067 xref: EHDAA2:0000932 xref: EHDAA:8307 xref: EMAPA:18178 xref: FMA:13357 xref: MA:0002331 xref: NCIT:C33150 xref: SCTID:181747008 xref: UMLS:C0224362 {source="ncithesaurus:Musculus_Latissimus_Dorsi"} xref: VHOG:0000930 xref: Wikipedia:Latissimus_dorsi_muscle is_a: UBERON:0001482 ! muscle of shoulder is_a: UBERON:0034908 ! scapular muscle relationship: BFO:0000050 UBERON:0008713 {source="EHDAA2"} ! part of pectoral girdle and thoracic body wall skeletal muscle relationship: RO:0002202 UBERON:0010982 {source="EHDAA2"} ! develops from latissimus dorsi pre-muscle mass relationship: RO:0002372 UBERON:0006849 ! has muscle origin scapula relationship: RO:0002372 UBERON:0007175 ! has muscle origin inferior angle of scapula relationship: RO:0002373 UBERON:0000976 ! has muscle insertion humerus relationship: RO:0002568 UBERON:0001476 {source="dbpedia"} ! has muscle antagonist deltoid relationship: RO:0002568 UBERON:0002380 {source="dbpedia"} ! has muscle antagonist trapezius muscle property_value: foaf:depiction "https://upload.wikimedia.org/wikipedia/commons/7/7d/Latissimus_dorsi.png" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001113 name: lobe of liver def: "Traditional gross anatomy divided the liver into four lobes based on surface features. The falciform ligament is visible on the front (anterior side) of the liver. This divides the liver into a left anatomical lobe, and a right anatomical lobe." [Wikipedia:Liver#Lobes] synonym: "hepatic lobe" EXACT [] synonym: "liver lobe" EXACT [] synonym: "lobus hepatis" EXACT [] xref: EMAPA:18306 xref: FMA:13361 xref: MA:0000360 xref: NCIT:C49579 xref: SCTID:245378000 xref: UMLS:C0447541 {source="ncithesaurus:Liver_Lobe"} xref: Wikipedia:Liver#Lobes is_a: UBERON:0009912 {source="FMA"} ! anatomical lobe relationship: BFO:0000050 UBERON:0002107 ! part of liver property_value: IAO:0000116 "some work needs to be done to ensure the child terms of this class have correct isa/partof placement. in MA they are subclasses, in FMA they are parts" xsd:string property_value: skos:prefLabel "lobe of liver" xsd:string [Term] id: UBERON:0001114 name: right lobe of liver def: "The right lobe is much larger than the left; the proportion between them being as six to one. It occupies the right hypochondrium, and is separated from the left lobe on its upper surface by the falciform ligament; on its under and posterior surfaces by the left sagittal fossa; and in front by the umbilical notch. It is of a somewhat quadrilateral form, its under and posterior surfaces being marked by three fossæ: the porta and the fossæ for the gall-bladder and inferior vena cava, which separate its left part into two smaller lobes; the quadrate and caudate lobes. [WP,unvetted]." [Wikipedia:Right_lobe_of_liver] subset: uberon_slim subset: vertebrate_core synonym: "2nd lobe" RELATED [TAO:0005173] synonym: "gall bladder lobe" RELATED SENSU [ZFA:0005173] synonym: "liver right lobe" EXACT [] synonym: "lobus hepaticus dexter" EXACT OMO:0003011 [] synonym: "lobus hepatis dexter" RELATED OMO:0003011 [Wikipedia:Right_lobe_of_liver] synonym: "right hepatic lobe" RELATED [EMAPA:18311] synonym: "right liver lobe" EXACT [ZFA:0005173] synonym: "second lobe" RELATED [TAO:0005173] xref: EHDAA2:0001008 xref: EHDAA:4001 xref: EMAPA:18311 xref: FMA:13362 xref: MA:0000363 xref: NCIT:C33481 xref: SCTID:362182008 xref: TAO:0005173 xref: UMLS:C0227481 {source="ncithesaurus:Right_Lobe_of_the_Liver"} xref: VHOG:0001424 xref: Wikipedia:Right_lobe_of_liver xref: ZFA:0005173 is_a: UBERON:0001113 ! lobe of liver property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/a/a3/Gray1087-liver.png" xsd:anyURI property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/liver-female/v1.2/assets/3d-vh-f-liver.glb" xsd:anyURI property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/liver-male/v1.2/assets/3d-vh-m-liver.glb" xsd:anyURI property_value: skos:prefLabel "right lobe of liver" xsd:string [Term] id: UBERON:0001115 name: left lobe of liver def: "The left lobe is smaller and more flattened than the right. It is situated in the epigastric and left hypochondriac regions. Its upper surface is slightly convex and is moulded on to the diaphragm; its under surface presents the gastric impression and omental tuberosity. [WP,unvetted]." [Wikipedia:Left_lobe_of_liver] subset: uberon_slim subset: vertebrate_core synonym: "left hepatic lobe" RELATED [EMAPA:18307] synonym: "left liver lobe" EXACT [] synonym: "liver left lobe" EXACT [] synonym: "lobus hepaticus sinister" EXACT OMO:0003011 [] synonym: "lobus hepatis sinister" RELATED OMO:0003011 [Wikipedia:Left_lobe_of_liver] xref: EHDAA2:0001000 xref: EHDAA:3995 xref: EMAPA:18307 xref: FMA:13363 xref: MA:0000361 xref: NCIT:C32965 xref: SCTID:362183003 xref: TAO:0005172 xref: UMLS:C0227486 {source="ncithesaurus:Left_Lobe_of_the_Liver"} xref: VHOG:0001423 xref: Wikipedia:Left_lobe_of_liver xref: ZFA:0005172 is_a: UBERON:0001113 ! lobe of liver property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/a/a3/Gray1087-liver.png" xsd:anyURI property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/liver-female/v1.2/assets/3d-vh-f-liver.glb" xsd:anyURI property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/liver-male/v1.2/assets/3d-vh-m-liver.glb" xsd:anyURI property_value: skos:prefLabel "left lobe of liver" xsd:string [Term] id: UBERON:0001118 name: lobe of thyroid gland def: "A lobe of tissue that is part of a thyroid gland." [http://orcid.org/0000-0002-6601-2165] comment: The lobes of the thyroid gland are conical in shape, the apex of each being directed upward and lateralward as far as the junction of the middle with the lower third of the thyroid cartilage; the base looks downward, and is on a level with the fifth or sixth tracheal ring. Each lobe is about 5 cm. long; its greatest width is about 3 cm. , and its thickness about 2 cm. The lateral or superficial surface is convex, and covered by the skin, the superficial and deep fasciæ, the Sternocleidomastoideus, the superior belly of the Omohyoideus, the Sternohyoideus and Sternothyreoideus, and beneath the last muscle by the pretracheal layer of the deep fascia, which forms a capsule for the gland. The deep or medial surface is moulded over the underlying structures, viz. , the thyroid and cricoid cartilages, the trachea, the Constrictor pharyngis inferior and posterior part of the Cricothyreoideus, the esophagus (particularly on the left side of the neck), the superior and inferior thyroid arteries, and the recurrent nerves. The anterior border is thin, and inclines obliquely from above downward toward the middle line of the neck, while the posterior border is thick and overlaps the common carotid artery, and, as a rule, the parathyroids synonym: "lobuli glandulae thyroideae" RELATED OMO:0003011 [Wikipedia:Lobes_of_thyroid_gland] synonym: "lobus (glandula thyroidea)" EXACT [] synonym: "lobus glandulae thyroideae" EXACT OMO:0003011 [FMA:13367, FMA:TA] synonym: "thyroid gland lobe" EXACT [] synonym: "thyroid lobe" EXACT [] xref: EHDAA2:0002032 xref: EMAPA:18196 xref: FMA:13367 xref: MA:0000131 xref: NCIT:C33784 xref: SCTID:245537001 xref: UMLS:C0447647 {source="ncithesaurus:Thyroid_Gland_Lobe"} xref: VHOG:0000732 xref: Wikipedia:Lobes_of_thyroid_gland is_a: UBERON:0009912 ! anatomical lobe is_a: UBERON:0015212 ! lateral structure intersection_of: UBERON:0009912 ! anatomical lobe intersection_of: BFO:0000050 UBERON:0002046 ! part of thyroid gland relationship: BFO:0000050 UBERON:0002046 ! part of thyroid gland relationship: BSPO:0000126 UBERON:0002046 {source="FMA-abduced-lr"} ! thyroid gland property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/9/9e/Gray1174.png" xsd:anyURI [Term] id: UBERON:0001119 name: right lobe of thyroid gland def: "A lobe of thyroid gland that is in the right side of a thyroid gland." [OBOL:automatic] synonym: "lobus dexter (glandula thyroidea)" EXACT [] synonym: "right thyroid lobe" EXACT [] synonym: "thyroid gland right lobe" EXACT [] xref: EHDAA2:0001759 xref: EMAPA:18198 xref: FMA:13368 xref: MA:0000729 xref: NCIT:C33491 xref: SCTID:170482008 xref: UMLS:C0229581 {source="ncithesaurus:Right_Thyroid_Gland_Lobe"} xref: VHOG:0000733 is_a: UBERON:0001118 ! lobe of thyroid gland intersection_of: UBERON:0001118 ! lobe of thyroid gland intersection_of: BSPO:0000121 UBERON:0002046 ! thyroid gland relationship: BSPO:0000121 UBERON:0002046 ! thyroid gland [Term] id: UBERON:0001120 name: left lobe of thyroid gland def: "A lobe of thyroid gland that is in the left side of a thyroid gland." [OBOL:automatic] synonym: "left thyroid lobe" EXACT [] synonym: "lobus sinister (glandula thyroidea)" EXACT [] synonym: "thyroid gland left lobe" EXACT [] xref: EHDAA2:0000965 xref: EMAPA:18197 xref: FMA:13369 xref: MA:0000728 xref: NCIT:C32973 xref: SCTID:170784008 xref: UMLS:C0229582 {source="ncithesaurus:Left_Thyroid_Gland_Lobe"} xref: VHOG:0000734 is_a: UBERON:0001118 ! lobe of thyroid gland intersection_of: UBERON:0001118 ! lobe of thyroid gland intersection_of: BSPO:0000120 UBERON:0002046 ! thyroid gland relationship: BSPO:0000120 UBERON:0002046 ! thyroid gland [Term] id: UBERON:0001125 name: serratus ventralis def: "The serratus ventralis is a muscle that originates on the surface of the upper eight or nine ribs at the side of the chest and inserts along the entire anterior length of the medial border of the scapula. [WP,unvetted]." [Wikipedia:Serratus_anterior_muscle] subset: human_reference_atlas subset: pheno_slim subset: uberon_slim synonym: "Boxer's muscle" EXACT [] synonym: "musculus serratus anterior" RELATED OMO:0003011 [Wikipedia:Serratus_anterior_muscle] synonym: "serratus anterior" EXACT [VHOG:0000679] synonym: "serratus anterior muscle" EXACT [] synonym: "serratus lateralis" RELATED OMO:0003011 [Wikipedia:Serratus_anterior_muscle] synonym: "serratus ventralis muscle" EXACT [] xref: EHDAA2:0001832 xref: EHDAA:9463 xref: EMAPA:18525 xref: FMA:13397 xref: MA:0002378 xref: NCIT:C53014 xref: SCTID:181748003 xref: UMLS:C1710059 {source="ncithesaurus:Serratus_Ventralis"} xref: VHOG:0000679 xref: Wikipedia:Serratus_anterior_muscle is_a: UBERON:0001482 ! muscle of shoulder is_a: UBERON:0034908 ! scapular muscle relationship: RO:0002005 UBERON:0003726 ! innervated by thoracic nerve relationship: RO:0002202 UBERON:0010986 {source="EHDAA2"} ! develops from serratus ventralis pre-muscle mass relationship: RO:0002372 UBERON:0002228 ! has muscle origin rib relationship: RO:0002373 UBERON:0006849 ! has muscle insertion scapula relationship: RO:0002568 UBERON:0002380 {source="dbpedia"} ! has muscle antagonist trapezius muscle property_value: foaf:depiction "https://upload.wikimedia.org/wikipedia/commons/c/c6/Serratus_anterior.png" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001130 name: vertebral column def: "Subdivision of skeletal system that consists of all the vertebra and associated skeletal elements and joints in the body[modified from VSAO]." [https://orcid.org/0000-0002-6601-2165, https://sourceforge.net/tracker/?func=detail&aid=3530322&group_id=76834&atid=2257941, VSAO:0000185] subset: efo_slim subset: human_reference_atlas subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "backbone" NARROW [FMA:13478] synonym: "columna vertebralis" RELATED [BTO:0000818] synonym: "dorsal spine" RELATED [BTO:0000818] synonym: "spinal column" RELATED [MESH:A02.835.232.834] synonym: "spine" BROAD [FMA:13478] synonym: "vertebral column skeleton" NARROW [AAO:0000699] synonym: "vertebral region" RELATED [] xref: AAO:0000699 xref: AAO:0000734 xref: BTO:0000818 xref: EFO:0001369 xref: EHDA:10119 xref: EMAPA:35919 xref: FMA:13478 xref: GAID:106 xref: galen:SpinalColumn xref: MA:0002416 xref: MESH:D013131 xref: NCIT:C12998 xref: NCIT:C33588 xref: NIF_Subcellular:sao1145756102 xref: SCTID:44300000 xref: TAO:0001559 xref: UMLS:C0037949 {source="ncithesaurus:Vertebral_Column"} xref: UMLS:C1519455 {source="ncithesaurus:Spinal_Cord_Column"} xref: VHOG:0001142 xref: VSAO:0000185 xref: Wikipedia:Vertebral_column xref: XAO:0003074 xref: ZFA:0001559 is_a: BFO:0000002 is_a: UBERON:0000075 ! subdivision of skeletal system intersection_of: UBERON:0000075 ! subdivision of skeletal system intersection_of: RO:0002473 UBERON:0010913 ! composed primarily of vertebral element relationship: BFO:0000050 UBERON:0011138 {source="cjm"} ! part of postcranial axial skeletal system relationship: protects UBERON:0002240 ! spinal cord relationship: RO:0002473 UBERON:0010913 ! composed primarily of vertebral element property_value: IAO:0000116 "Note that in contrast to VSAO, this is a subset of the skeletal system, and thus includes intervertebral joints, cartilage and ligaments etc. Some ontologies such as AAO seem to purely refer to the skeleton" xsd:string property_value: RO:0002161 NCBITaxon:7762 property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "vertebral column" xsd:string [Term] id: UBERON:0001131 name: vertebral foramen def: "A foramen within a vertebral element through which the spinal cord runs. It is formed by the anterior segment, and the posterior part, the vertebral arch." [http://orcid.org/0000-0002-6601-2165, Wikipedia:Vertebral_foramen] subset: uberon_slim synonym: "foramen vertebrale" RELATED OMO:0003011 [Wikipedia:Vertebral_foramen] synonym: "vertebra neural canal" EXACT [] xref: AAO:0000729 xref: EMAPA:37803 {source="MA:th"} xref: FMA:13479 xref: MA:0001454 xref: SCTID:280734009 xref: Wikipedia:Vertebral_foramen is_a: UBERON:0004111 ! anatomical conduit intersection_of: UBERON:0004111 ! anatomical conduit intersection_of: RO:0002570 UBERON:0002240 ! conduit for spinal cord intersection_of: RO:0002571 UBERON:0010913 ! lumen of vertebral element relationship: BFO:0000050 UBERON:0006692 ! part of vertebral canal relationship: RO:0002570 UBERON:0002240 ! conduit for spinal cord relationship: RO:0002571 UBERON:0010913 ! lumen of vertebral element property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/1/10/Foramenvertebrale.png" xsd:anyURI [Term] id: UBERON:0001132 name: parathyroid gland def: "The parathyroid gland is an endocrine gland for secretion of parathyroid hormone, usually found as a pair, embedded in the connective tissue capsule on the posterior surface of the thyroid gland. Parathyroid regulates calcium and phosphorous metabolism." [ISBN:0-683-40008-8, MP:0000678, Wikipedia:Parathyroid_gland] subset: organ_slim subset: pheno_slim subset: uberon_slim synonym: "epithelial body" RELATED [XAO:0000167] synonym: "parathyroid" EXACT [] synonym: "parathyroid secreting cell" RELATED [] xref: AAO:0010545 xref: BTO:0000997 xref: CALOHA:TS-0745 xref: EFO:0000862 xref: EMAPA:32812 xref: EV:0100134 xref: FMA:13890 xref: GAID:452 xref: MA:0000128 xref: MAT:0000082 xref: MESH:D010280 xref: MIAA:0000082 xref: NCIT:C12765 xref: SCTID:181121007 xref: UMLS:C0030518 {source="ncithesaurus:Parathyroid_Gland"} xref: VHOG:0001188 xref: Wikipedia:Parathyroid_gland xref: XAO:0000167 is_a: UBERON:0002368 ! endocrine gland relationship: RO:0002162 NCBITaxon:32523 {source="PMID:16313389"} ! in taxon Tetrapoda relationship: RO:0002215 GO:0035898 ! capable of parathyroid hormone secretion relationship: RO:0002216 GO:0055074 {source="Wikipedia"} ! capable of part of calcium ion homeostasis [Term] id: UBERON:0001133 name: cardiac muscle tissue def: "Muscle tissue composed of cardiac muscle cells, forming the muscles of the heart[ZFA,modified]." [ZFA:0005280] subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "cardiac muscle" EXACT [] synonym: "cardiac muscle muscle tissue" EXACT [OBOL:automatic] synonym: "cardiac muscle textus muscularis" EXACT [OBOL:automatic] synonym: "cardiac musculature" RELATED [BILA:0000134] synonym: "heart muscle muscle tissue" EXACT [OBOL:automatic] synonym: "heart muscle textus muscularis" EXACT [OBOL:automatic] synonym: "heart myocardium muscle tissue" EXACT [OBOL:automatic] synonym: "heart myocardium textus muscularis" EXACT [OBOL:automatic] synonym: "muscle of heart muscle tissue" EXACT [OBOL:automatic] synonym: "muscle of heart textus muscularis" EXACT [OBOL:automatic] synonym: "muscle tissue of cardiac muscle" EXACT [OBOL:automatic] synonym: "muscle tissue of heart muscle" EXACT [OBOL:automatic] synonym: "muscle tissue of heart myocardium" EXACT [OBOL:automatic] synonym: "muscle tissue of muscle of heart" EXACT [OBOL:automatic] synonym: "muscle tissue of myocardium" EXACT [OBOL:automatic] synonym: "myocardium muscle tissue" EXACT [OBOL:automatic] synonym: "myocardium textus muscularis" EXACT [OBOL:automatic] synonym: "textus muscularis of cardiac muscle" EXACT [OBOL:automatic] synonym: "textus muscularis of heart muscle" EXACT [OBOL:automatic] synonym: "textus muscularis of heart myocardium" EXACT [OBOL:automatic] synonym: "textus muscularis of muscle of heart" EXACT [OBOL:automatic] synonym: "textus muscularis of myocardium" EXACT [OBOL:automatic] xref: AAO:0010245 xref: AEO:0000142 xref: BILA:0000134 xref: BTO:0000199 xref: CALOHA:TS-0440 xref: EHDAA2:0003142 xref: EMAPA:32688 xref: FMA:14068 xref: galen:CardiacMuscle xref: galen:CardiacMuscleTissue xref: ncithesaurus:Heart_Muscle xref: TAO:0005280 xref: Wikipedia:Cardiac_muscle xref: ZFA:0005280 is_a: UBERON:8600006 ! visceral striated muscle tissue intersection_of: UBERON:0002036 ! striated muscle tissue intersection_of: BFO:0000051 CL:0000746 ! has part cardiac muscle cell disjoint_from: UBERON:0001134 ! skeletal muscle tissue relationship: BFO:0000050 UBERON:0007100 ! part of primary circulatory organ relationship: RO:0002473 CL:0000746 ! composed primarily of cardiac muscle cell property_value: IAO:0000116 "check relationship with myocardium. part_of in MA - but we also have a more specific class 'cardiac muscle tissue of myocardium'. Check ncit" xsd:string property_value: skos:prefLabel "cardiac muscle tissue" xsd:string [Term] id: UBERON:0001134 name: skeletal muscle tissue def: "Muscle tissue that consists primarily of skeletal muscle fibers." [https://github.com/obophenotype/uberon/issues/324] subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "skeletal muscle" BROAD [] synonym: "skeletal muscle system" RELATED [BTO:0001103] synonym: "somatic muscle" RELATED [BTO:0001103] xref: EMAPA:32716 xref: FMA:14069 xref: MA:0002439 xref: NCIT:C13050 xref: SCTID:426215008 xref: UMLS:C0242692 {source="ncithesaurus:Skeletal_Muscle_Tissue"} xref: Wikipedia:Skeletal_striated_muscle is_a: UBERON:0002036 ! striated muscle tissue intersection_of: UBERON:0002385 ! muscle tissue intersection_of: RO:0002473 CL:0008002 ! composed primarily of skeletal muscle fiber relationship: BFO:0000050 UBERON:0014892 ! part of skeletal muscle organ, vertebrate relationship: RO:0002202 UBERON:0003082 ! develops from myotome relationship: RO:0002473 CL:0008002 ! composed primarily of skeletal muscle fiber property_value: foaf:depiction "https://upload.wikimedia.org/wikipedia/commons/c/c0/Skeletal_muscle.jpg" xsd:anyURI property_value: IAO:0000116 "TODO - add skeletal muscle organ? See GO:0060538 skeletal muscle organ development. Todo - group FBbt:00005073 - somatic muscle." xsd:string property_value: skos:prefLabel "skeletal muscle tissue" xsd:string property_value: terms:contributor https://orcid.org/0000-0001-9114-8737 property_value: terms:contributor https://orcid.org/0000-0002-1572-1316 property_value: terms:contributor https://orcid.org/0000-0002-6601-2165 property_value: terms:contributor https://orcid.org/0000-0002-7073-9172 [Term] id: UBERON:0001135 name: smooth muscle tissue def: "Muscle tissue which is unstriated, composed primarily of smooth muscle fibers surrounded by a reticulum of collagen and elastic fibers. Smooth muscle differs from striated muscle in the much higher actin/myosin ratio, the absence of conspicuous sarcomeres and the ability to contract to a much smaller fraction of its resting length[GO]." [GO:0006939, Wikipedia:Smooth_muscle_tissue] subset: efo_slim subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "involuntary muscle" EXACT [] synonym: "non-striated muscle" EXACT [] synonym: "smooth muscle" EXACT [] synonym: "textus muscularis levis; textus muscularis nonstriatus" RELATED OMO:0003011 [Wikipedia:Smooth_muscle_tissue] synonym: "textus muscularis nonstriatus" EXACT OMO:0003011 [FMA:14070, FMA:TA] synonym: "visceral muscle" NARROW SENSU [] synonym: "visceral muscle tissue" NARROW SENSU [] xref: AAO:0010244 xref: AEO:0000141 xref: BTO:0001260 xref: CALOHA:TS-0943 xref: EFO:0000889 xref: EHDAA2:0003141 xref: EMAPA:32717 xref: EV:0100378 xref: FMA:14070 xref: GAID:167 xref: galen:SmoothMuscle xref: galen:SmoothMuscleTissue xref: MA:0000166 xref: MAT:0000303 xref: MESH:D009130 xref: MIAA:0000303 xref: NCIT:C12437 xref: TAO:0005274 xref: UMLS:C1267092 {source="ncithesaurus:Smooth_Muscle_Tissue"} xref: VHOG:0001246 xref: WBbt:0005781 xref: Wikipedia:Smooth_muscle_tissue xref: XAO:0000175 xref: ZFA:0005274 is_a: UBERON:0002385 ! muscle tissue intersection_of: UBERON:0002385 ! muscle tissue intersection_of: BFO:0000051 CL:0000192 ! has part smooth muscle cell disjoint_from: UBERON:0002036 ! striated muscle tissue relationship: BFO:0000051 GO:0071953 ! has part elastic fiber relationship: RO:0002473 CL:0000192 ! composed primarily of smooth muscle cell property_value: foaf:depiction "https://upload.wikimedia.org/wikipedia/commons/3/3b/Glatte_Muskelzellen.jpg" xsd:anyURI property_value: skos:prefLabel "smooth muscle tissue" xsd:string [Term] id: UBERON:0001136 name: mesothelium def: "Simple squamous epithelium of mesodermal origin which lines serous membranes. Examples: mesothelium of pleura, mesothelium of peritoneum[FMA]. Wikipedia: The mesothelium is a membrane that forms the lining of several body cavities: the pleura (thoracal cavity), peritoneum (abdominal cavity including the mesentery) and pericardium (heart sac). Mesothelial tissue also surrounds the male internal reproductive organs (the tunica vaginalis testis) and covers the internal reproductive organs of women (the tunica serosa uteri)." [FMA:14074, Wikipedia:Mesothelium] subset: uberon_slim xref: AEO:0000111 xref: BTO:0002422 xref: CALOHA:TS-1183 xref: EHDAA2_RETIRED:0003111 xref: EHDAA:2331 xref: EHDAA:2349 xref: EHDAA:295 xref: EHDAA:6073 xref: EHDAA:640 xref: EHDAA:646 xref: EMAPA:32856 xref: FMA:14074 xref: MA:0000565 xref: NCIT:C33105 xref: SCTID:361918002 xref: UMLS:C0086610 {source="ncithesaurus:Mesothelium"} xref: Wikipedia:Mesothelium is_a: UBERON:0000487 ! simple squamous epithelium is_a: UBERON:0012275 ! meso-epithelium intersection_of: UBERON:0000487 ! simple squamous epithelium intersection_of: BFO:0000050 UBERON:0000042 ! part of serous membrane intersection_of: RO:0002202 UBERON:0000926 ! develops from mesoderm relationship: BFO:0000050 UBERON:0000042 ! part of serous membrane relationship: RO:0002473 CL:0000077 {source="FMA"} ! composed primarily of mesothelial cell property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/2/25/Mesothelium_peritoneal_wash_high_mag.jpg" xsd:anyURI property_value: skos:prefLabel "mesothelium" xsd:string [Term] id: UBERON:0001137 name: dorsum def: "A major subdivision of an organism that is the entire part of the organism dorsal to a horizontal plane and bounded on one side by the same transverse plane. In vertebrares this includes the vertebral column.." [BSPO:0000063, UBERONREF:0000006, Wikipedia:Dorsum_(anatomy)] subset: efo_slim subset: uberon_slim synonym: "back" EXACT [FMA:14181] synonym: "back of body proper" EXACT [FMA:14181] synonym: "dorsal part of organism" EXACT [] xref: BTO:0001713 xref: CALOHA:TS-2223 xref: EFO:0001405 xref: FMA:14181 xref: GAID:30 xref: galen:Back xref: MESH:D001415 xref: NCIT:C13062 xref: SCTID:123961009 xref: UMLS:C0004600 {source="ncithesaurus:Back"} xref: Wikipedia:Dorsum_(anatomy) is_a: UBERON:0000475 ! organism subdivision relationship: RO:0002162 NCBITaxon:33213 ! in taxon Bilateria property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/e/ee/432px-Gray-back.PNG" xsd:anyURI property_value: skos:prefLabel "dorsum" xsd:string [Term] id: UBERON:0001138 name: superior mesenteric vein def: "In anatomy, the superior mesenteric vein (SMV) is a blood vessel that drains blood from the small intestine. At its termination behind the neck of the pancreas, the SMV combines with the splenic vein to form the hepatic portal vein. The SMV lies to the right of the similarly named artery, the superior mesenteric artery, which originates from the abdominal aorta. [WP,unvetted]." [Wikipedia:Superior_mesenteric_vein] subset: human_reference_atlas subset: uberon_slim synonym: "upper mesenteric vein" RELATED [BTO:0002783] synonym: "vena mesenterica superior" RELATED OMO:0003011 [Wikipedia:Superior_mesenteric_vein] xref: BTO:0002783 xref: EHDAA2:0001951 xref: EHDAA:5414 xref: EMAPA:18643 xref: FMA:14332 xref: MA:0002179 xref: NCIT:C33687 xref: SCTID:278031001 xref: UMLS:C0226742 {source="ncithesaurus:Superior_Mesenteric_Vein"} xref: VHOG:0000552 xref: Wikipedia:Superior_mesenteric_vein is_a: UBERON:0005617 ! mesenteric vein intersection_of: UBERON:0005617 ! mesenteric vein intersection_of: RO:0020102 UBERON:0002108 ! vessel drains blood from small intestine relationship: BFO:0000050 UBERON:0005806 ! part of portal system relationship: RO:0002170 UBERON:0001639 ! connected to hepatic portal vein relationship: RO:0002202 UBERON:0005487 {source="Wikipedia:Vitelline_vein"} ! develops from vitelline vein relationship: RO:0020102 UBERON:0002108 ! vessel drains blood from small intestine property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/3/33/Gray591.png" xsd:anyURI property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/blood-vasculature-female/v1.3/assets/3d-vh-f-blood-vasculature.glb" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "superior mesenteric vein" xsd:string [Term] id: UBERON:0001139 name: common iliac vein def: "A vein that drains the pelvis and lower limbs into the inferior vena cava." [MURDOCH:403, Wikipedia:Common_iliac_vein] subset: human_reference_atlas subset: uberon_slim synonym: "common iliac venous tree" EXACT [] synonym: "vena iliaca communis" RELATED OMO:0003011 [Wikipedia:Common_iliac_vein] xref: EMAPA:17874 xref: FMA:14333 xref: galen:CommonIliacVein xref: MA:0002143 xref: NCIT:C32359 xref: SCTID:181398004 xref: UMLS:C0226758 {source="ncithesaurus:Common_Iliac_Vein"} xref: Wikipedia:Common_iliac_vein is_a: UBERON:0005610 {source="MA"} ! iliac vein is_a: UBERON:0015212 ! lateral structure relationship: BSPO:0000126 UBERON:0001072 {source="FMA-abduced-lr"} ! inferior vena cava property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/blood-vasculature-female/v1.3/assets/3d-vh-f-blood-vasculature.glb" xsd:anyURI property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/blood-vasculature-male/v1.3/assets/3d-vh-m-blood-vasculature.glb" xsd:anyURI property_value: foaf:depiction "https://upload.wikimedia.org/wikipedia/commons/6/65/Iliac_veins.gif" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001140 name: renal vein def: "Either of the pair of major vessels which arise from the renal hilus and return blood from the kidneys, suprarenal gland and the ureter to the inferior vena cava." [ISBN:0-683-40008-8, MGI:csmith, MP:0011323] subset: human_reference_atlas subset: pheno_slim subset: uberon_slim synonym: "kidney vein" EXACT [OBOL:automatic] synonym: "renal venous tree" EXACT [] synonym: "vein of kidney" EXACT [OBOL:automatic] synonym: "venae renales" RELATED OMO:0003011 [Wikipedia:Renal_vein] xref: BTO:0002681 xref: EHDAA2:0001602 xref: EHDAA:8722 xref: EMAPA:28376 xref: FMA:14334 xref: GAID:544 xref: galen:RenalVein xref: MA:0002210 xref: MESH:D012082 xref: NCIT:C33462 xref: SCTID:116358006 xref: UMLS:C0035092 {source="ncithesaurus:Renal_Vein"} xref: Wikipedia:Renal_vein is_a: UBERON:0001638 ! vein intersection_of: UBERON:0001638 ! vein intersection_of: RO:0020102 UBERON:0002113 ! vessel drains blood from kidney relationship: RO:0002376 UBERON:0001072 ! tributary of inferior vena cava relationship: RO:0020102 UBERON:0002113 ! vessel drains blood from kidney property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/7/76/Gray1122.png" xsd:anyURI property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/blood-vasculature-female/v1.3/assets/3d-vh-f-blood-vasculature.glb" xsd:anyURI property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/blood-vasculature-male/v1.3/assets/3d-vh-m-blood-vasculature.glb" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001141 name: right renal vein def: "A renal vein that drains the right kidney." [http://orcid.org/0000-0002-6601-2165] subset: human_reference_atlas subset: pheno_slim xref: EMAPA:37381 {source="MA:th"} xref: FMA:14335 xref: MA:0002212 xref: NCIT:C52695 xref: SCTID:116357001 xref: UMLS:C0508000 {source="ncithesaurus:Right_Renal_Vein"} is_a: UBERON:0001140 ! renal vein intersection_of: UBERON:0001140 ! renal vein intersection_of: RO:0020102 UBERON:0004539 ! vessel drains blood from right kidney relationship: RO:0020102 UBERON:0004539 ! vessel drains blood from right kidney property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/blood-vasculature-female/v1.3/assets/3d-vh-f-blood-vasculature.glb" xsd:anyURI property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/blood-vasculature-male/v1.3/assets/3d-vh-m-blood-vasculature.glb" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001142 name: left renal vein def: "A renal vein that drains the left kidney." [http://orcid.org/0000-0002-6601-2165] subset: human_reference_atlas subset: pheno_slim xref: EMAPA:37166 {source="MA:th"} xref: FMA:14336 xref: MA:0002211 xref: NCIT:C52693 xref: SCTID:116356005 xref: UMLS:C0508001 {source="ncithesaurus:Left_Renal_Vein"} is_a: UBERON:0001140 ! renal vein intersection_of: UBERON:0001140 ! renal vein intersection_of: RO:0020102 UBERON:0004538 ! vessel drains blood from left kidney relationship: RO:0020102 UBERON:0004538 ! vessel drains blood from left kidney property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/7/76/Gray1122.png" xsd:anyURI property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/blood-vasculature-female/v1.3/assets/3d-vh-f-blood-vasculature.glb" xsd:anyURI property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/blood-vasculature-male/v1.3/assets/3d-vh-m-blood-vasculature.glb" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001143 name: hepatic vein def: "Vein that carries blood away from the liver[ZFA]." [https://sourceforge.net/tracker/?func=detail&aid=3565355&group_id=76834&atid=1205376, Wikipedia:Hepatic_vein, ZFA:0000670] subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "hepatic veins" RELATED OMO:0003004 [] synonym: "liver vein" EXACT [OBOL:automatic] synonym: "vein of liver" EXACT [OBOL:automatic] synonym: "vena hepatica" EXACT OMO:0003011 [] synonym: "venae hepaticae" RELATED OMO:0003011 [Wikipedia:Hepatic_vein] xref: AAO:0010216 xref: EMAPA:19221 xref: FMA:14337 xref: GAID:534 xref: galen:HepaticVein xref: MA:0003015 xref: MESH:D006503 xref: NCIT:C32736 xref: SCTID:278191001 xref: TAO:0000670 xref: UMLS:C0019155 {source="ncithesaurus:Hepatic_Vein"} xref: Wikipedia:Hepatic_vein xref: XAO:0000387 xref: ZFA:0000670 is_a: UBERON:0013126 ! vein of abdomen is_a: UBERON:0015796 ! liver blood vessel intersection_of: UBERON:0001638 ! vein intersection_of: RO:0020102 UBERON:0002107 ! vessel drains blood from liver disjoint_from: UBERON:0001639 ! hepatic portal vein relationship: BFO:0000050 UBERON:0006877 ! part of vasculature of liver relationship: RO:0002376 UBERON:0001072 {source="FMA-abduced-lr"} ! tributary of inferior vena cava relationship: RO:0020102 UBERON:0002107 ! vessel drains blood from liver property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/6/61/Gray1121.png" xsd:anyURI property_value: IAO:0000116 "todo - add developmental relationships for other taxa" xsd:string property_value: skos:prefLabel "hepatic vein" xsd:string [Term] id: UBERON:0001144 name: testicular vein def: "A vein that carries deoxygenated blood from a single male gonad. It is the male equivalent of the ovarian vein, and is the venous counterpart of the testicular artery. It is a paired vein, with one supplying each testis." [http://orcid.org/0000-0002-6601-2165, https://sourceforge.net/tracker/?func=detail&aid=3220553&group_id=76834&atid=1205376, Wikipedia:Testicular_vein] subset: uberon_slim synonym: "male gonadal vein" EXACT [Wikipedia:Testicular_vein] synonym: "spermatic vein" EXACT [Wikipedia:Testicular_vein] synonym: "testicle vein" EXACT [OBOL:automatic] synonym: "testicular venous tree" EXACT [Wikipedia:Testicular_vein] synonym: "vein of testicle" EXACT [OBOL:automatic] synonym: "vena tesicularis" RELATED [BTO:0002678] synonym: "vena testicularis dextra" RELATED OMO:0003011 [Wikipedia:Testicular_vein] synonym: "vena testicularis sinistra" RELATED OMO:0003011 [Wikipedia:Testicular_vein] synonym: "venae spermaticae" RELATED OMO:0003011 [Wikipedia:Testicular_vein] xref: BTO:0002678 xref: EMAPA:18647 xref: FMA:14344 xref: MA:0002218 xref: MA:0002234 xref: NCIT:C53050 xref: SCTID:264496006 xref: UMLS:C0226718 {source="ncithesaurus:Spermatic_Vein"} xref: Wikipedia:Testicular_vein is_a: UBERON:0001638 ! vein is_a: UBERON:0015212 ! lateral structure intersection_of: UBERON:0001638 ! vein intersection_of: RO:0020102 UBERON:0000473 ! vessel drains blood from testis relationship: BSPO:0000126 UBERON:0000468 ! multicellular organism relationship: RO:0002170 UBERON:0001072 ! connected to inferior vena cava relationship: RO:0002170 UBERON:0001330 ! connected to pampiniform plexus relationship: RO:0020102 UBERON:0000473 ! vessel drains blood from testis relationship: sexually_homologous_to UBERON:0001145 ! ovarian vein property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/1/1b/Gray590.png" xsd:anyURI property_value: IAO:0000116 "TODO - check testicular vs spermatic vein (MA:0002218)" xsd:string [Term] id: UBERON:0001145 name: ovarian vein def: "A vein that carries deoxygenated blood from its corresponding ovary to inferior vena cava or one of its tributaries." [Wikipedia:Ovarian_vein] subset: uberon_slim synonym: "female reproductive system gonad vein" EXACT [OBOL:automatic] synonym: "female reproductive system gonada vein" EXACT [OBOL:automatic] synonym: "gonad of female reproductive system vein" EXACT [OBOL:automatic] synonym: "gonada of female reproductive system vein" EXACT [OBOL:automatic] synonym: "ovary vein" EXACT [OBOL:automatic] synonym: "vein of female reproductive system gonad" EXACT [OBOL:automatic] synonym: "vein of female reproductive system gonada" EXACT [OBOL:automatic] synonym: "vein of gonad of female reproductive system" EXACT [OBOL:automatic] synonym: "vein of gonada of female reproductive system" EXACT [OBOL:automatic] synonym: "vein of ovary" EXACT [OBOL:automatic] synonym: "vena ovarica dextra" RELATED OMO:0003011 [Wikipedia:Ovarian_vein] synonym: "vena ovarica sinistra" RELATED OMO:0003011 [Wikipedia:Ovarian_vein] xref: EMAPA:18644 xref: FMA:14346 xref: MA:0002186 xref: NCIT:C53058 xref: SCTID:278193003 xref: UMLS:C0226720 {source="ncithesaurus:Ovarian_Vein"} xref: Wikipedia:Ovarian_vein is_a: UBERON:0001638 ! vein is_a: UBERON:0015212 ! lateral structure intersection_of: UBERON:0001638 ! vein intersection_of: RO:0020102 UBERON:0000992 ! vessel drains blood from ovary relationship: BSPO:0000126 UBERON:0000468 ! multicellular organism relationship: RO:0020102 UBERON:0000992 ! vessel drains blood from ovary property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/c/cf/Ovarschaf.jpg" xsd:anyURI property_value: skos:prefLabel "ovarian vein" xsd:string [Term] id: UBERON:0001146 name: suprarenal vein def: "A vein that drains the adrenal gland." [http://orcid.org/0000-0002-6601-2165, https://github.com/obophenotype/mouse-anatomy-ontology/issues/110] subset: uberon_slim synonym: "adrenal vein" RELATED [MA:0002081] xref: EHDAA2:0001966 xref: EHDAA:8731 xref: FMA:14348 xref: MA:0002081 xref: MA:0002229 xref: NCIT:C53129 xref: SCTID:278194009 xref: UMLS:C0226717 {source="ncithesaurus:Suprarenal_Vein"} xref: Wikipedia:Suprarenal_vein is_a: UBERON:0001638 ! vein intersection_of: UBERON:0001638 ! vein intersection_of: RO:0020102 UBERON:0002369 ! vessel drains blood from adrenal gland relationship: RO:0020102 UBERON:0002369 ! vessel drains blood from adrenal gland property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/7/76/Gray1122.png" xsd:anyURI [Term] id: UBERON:0001152 name: cystic duct def: "The tubular structure that conducts gall bladder contents from the gall bladder to the common bile duct." [ISBN:0-683-40008-8, MP:0009493] subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "ductus cysticus" RELATED OMO:0003011 [Wikipedia:Cystic_duct] xref: EHDAA2:0000333 xref: EHDAA:3045 xref: EMAPA:16841 xref: FMA:14539 xref: GAID:290 xref: galen:CysticDuct xref: MA:0000355 xref: MESH:D003549 xref: NCIT:C32421 xref: SCTID:245398005 xref: TAO:0005166 xref: UMLS:C0010672 {source="ncithesaurus:Cystic_Duct"} xref: VHOG:0000213 xref: Wikipedia:Cystic_duct xref: ZFA:0005166 is_a: UBERON:0003703 {source="FMA"} ! extrahepatic bile duct intersection_of: UBERON:0000058 ! duct intersection_of: RO:0002150 UBERON:0001174 ! continuous with common bile duct intersection_of: RO:0002150 UBERON:0002110 ! continuous with gallbladder disjoint_from: UBERON:0005171 ! hepatic duct relationship: channels_into UBERON:0001174 ! common bile duct relationship: RO:0002150 UBERON:0001174 ! continuous with common bile duct relationship: RO:0002150 UBERON:0002110 ! continuous with gallbladder relationship: RO:0002202 UBERON:0005604 {source="EHDAA2"} ! develops from extrahepatic part of hepatic duct property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/4/48/Illu_liver_gallbladder.jpg" xsd:anyURI property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/5/5d/Digestive_system_showing_bile_duct.png" xsd:anyURI property_value: skos:prefLabel "cystic duct" xsd:string [Term] id: UBERON:0001153 name: caecum def: "A pouch in the digestive tract that connects the ileum with the ascending colon of the large intestine. It is separated from the ileum by the ileocecal valve, and is the beginning of the large intestine. It is also separated from the colon by the cecocolic junction." [Wikipedia:Cecum] comment: Taxon notes: in some herbivorous lizards, a cecum is present between small and large intestines[Kardong] subset: efo_slim subset: human_reference_atlas subset: pheno_slim subset: uberon_slim synonym: "blind intestine" RELATED [BTO:0000166] synonym: "blindgut" RELATED [BTO:0000166] synonym: "caeca" NARROW OMO:0003004 [NCBITaxon:8782] synonym: "caecum" EXACT [VHOG:0001559] synonym: "ceca" NARROW OMO:0003004 [NCBITaxon:8782] synonym: "cecum" EXACT [FMA:14541] synonym: "intestinum caecum" RELATED [BTO:0000166] synonym: "intestinum crassum caecum" EXACT [] synonym: "intestinum crassum cecum" RELATED [BTO:0000166] xref: BTO:0000166 xref: CALOHA:TS-0122 xref: EFO:0000850 xref: EHDAA2:0000206 xref: EHDAA:3913 xref: EMAPA:35197 xref: EV:0100397 xref: FMA:14541 xref: GAID:307 xref: galen:Cecum xref: MA:0000334 xref: MESH:D002432 xref: MIAA:0000288 xref: NCIT:C12381 xref: SCTID:181256004 xref: UMLS:C0007531 {source="ncithesaurus:Cecum"} xref: VHOG:0001559 xref: Wikipedia:Cecum is_a: BFO:0000002 is_a: UBERON:0009854 ! digestive tract diverticulum relationship: BFO:0000050 UBERON:0001155 {source="EHDAA2"} ! part of colon relationship: RO:0002150 UBERON:0001156 {source="Wikipedia"} ! continuous with ascending colon relationship: RO:0002162 NCBITaxon:7776 ! in taxon Gnathostomata relationship: RO:0002202 UBERON:0001045 {source="Wikipedia"} ! develops from midgut relationship: RO:0002433 UBERON:0000059 ! contributes to morphology of large intestine property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/8/82/Stomach_colon_rectum_diagram.svg" xsd:anyURI property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/large-intestine-female/v1.3/assets/3d-sbu-f-large-intestine.glb" xsd:anyURI property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/large-intestine-male/v1.3/assets/3d-sbu-m-large-intestine.glb" xsd:anyURI property_value: RO:0002161 NCBITaxon:32443 {source="Wikipedia"} property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001154 name: vermiform appendix def: "A blind-ended tube connected to the cecum, from which it develops embryologically[WP]." [https://orcid.org/0000-0002-6826-8770, Wikipedia:Vermiform_appendix] subset: efo_slim subset: human_reference_atlas subset: organ_slim subset: uberon_slim synonym: "apex of caecum" RELATED [EMAPA:35140] synonym: "apex of cecum" RELATED [VHOG:0001306] synonym: "appendix" EXACT [] synonym: "appendix vermiformis" EXACT OMO:0003011 [FMA:14542, FMA:TA] synonym: "appendix vermiformis" RELATED OMO:0003011 [Wikipedia:Vermiform_appendix] synonym: "caecal appendix" EXACT [] synonym: "cecal appendix" EXACT [] synonym: "vermix" BROAD [] xref: BTO:0000084 xref: CALOHA:TS-1267 xref: EFO:0000849 xref: EHDAA2:0000588 xref: EMAPA:35140 xref: EV:0100076 xref: EV:0100080 xref: FMA:14542 xref: GAID:308 xref: galen:AppendixVermiformis xref: MA:0001540 xref: MAT:0000287 xref: MESH:D001065 xref: MIAA:0000287 xref: NCIT:C12380 xref: SCTID:181255000 xref: UMLS:C0003617 {source="ncithesaurus:Vermiform_Appendix"} xref: VHOG:0001306 xref: Wikipedia:Vermiform_appendix is_a: BFO:0000002 is_a: UBERON:0013765 ! digestive system element relationship: BFO:0000050 UBERON:0000059 ! part of large intestine relationship: RO:0002150 UBERON:0001153 {xref="http://orcid.org/0000-0002-1572-1316"} ! continuous with caecum relationship: RO:0002202 UBERON:0001045 {source="Wikipedia"} ! develops from midgut property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/a/ad/Gray536.png" xsd:anyURI property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/large-intestine-female/v1.3/assets/3d-sbu-f-large-intestine.glb" xsd:anyURI property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/large-intestine-male/v1.3/assets/3d-sbu-m-large-intestine.glb" xsd:anyURI property_value: RO:0002175 NCBITaxon:40674 property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001155 name: colon def: "A portion of the large intestine before it becomes the rectum. In mammals, the colon is the most part of the large intestine, excluding the vermiform appendix, the rectum and the anal canal." [http://orcid.org/0000-0002-2825-0621, http://orcid.org/0000-0002-6601-2165, Wikipedia:Colon_(anatomy), ZFIN:curator] subset: efo_slim subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "hindgut" RELATED [] synonym: "large bowel" EXACT [] synonym: "posterior intestine" NARROW [] xref: AAO:0010400 xref: BTO:0000269 xref: CALOHA:TS-0158 xref: EFO:0000361 xref: EMAPA:18939 xref: EV:0100079 xref: FMA:14543 xref: GAID:309 xref: galen:Colon xref: MA:0000335 xref: MAP:0000001 xref: MAT:0000526 xref: MESH:D003106 xref: NCIT:C12382 xref: SCTID:302508007 xref: TAO:0000706 xref: UMLS:C0009368 {source="ncithesaurus:Colon"} xref: VHOG:0000648 xref: Wikipedia:Colon_(anatomy) xref: XAO:0000243 xref: ZFA:0000706 is_a: UBERON:0004921 ! subdivision of digestive tract relationship: BFO:0000050 UBERON:0000059 {source="FMA"} ! part of large intestine relationship: RO:0002433 UBERON:0000059 ! contributes to morphology of large intestine property_value: IAO:0000116 "Some references do not consider the caecum to be part of the colon." xsd:string {xref="http://orcid.org/0000-0002-1572-1316"} property_value: IAO:0000116 "TODO - abstract this such that it legitimately covers all vertebrates" xsd:string property_value: skos:prefLabel "colon" xsd:string [Term] id: UBERON:0001156 name: ascending colon def: "Section of colon which is distal to the cecum and proximal to the transversecolon.[FMA,modified]." [FMA:14545, Wikipedia:Ascending_colon] subset: efo_slim subset: human_reference_atlas subset: uberon_slim synonym: "colon ascendens" EXACT OMO:0003011 [Wikipedia:Ascending_colon] synonym: "spiral colon" RELATED SENSU [Wikipedia:Spiral_colon] xref: BTO:0000270 xref: CALOHA:TS-0057 xref: EFO:0000843 xref: EMAPA:35151 xref: FMA:14545 xref: galen:AscendingColon xref: MA:0001541 xref: MAT:0000311 xref: MIAA:0000311 xref: NCIT:C12265 xref: SCTID:362162009 xref: UMLS:C0227375 {source="ncithesaurus:Ascending_Colon"} xref: Wikipedia:Ascending_colon is_a: BFO:0000002 is_a: UBERON:0000168 {source="FMA"} ! proximal-distal subdivision of colon relationship: RO:0002150 UBERON:0001157 ! continuous with transverse colon relationship: RO:0002202 UBERON:0001045 {source="Wikipedia"} ! develops from midgut property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/3/3b/Dickdarm-Schema.svg" xsd:anyURI property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/large-intestine-female/v1.3/assets/3d-sbu-f-large-intestine.glb" xsd:anyURI property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/large-intestine-male/v1.3/assets/3d-sbu-m-large-intestine.glb" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001157 name: transverse colon def: "The proximal-distal subdivision of colon that runs transversely across the upper part of the abdomen, from the right to the left colic flexure. Continuous with the descending colon[BTO,modified]." [BTO:0000272, Wikipedia:Transverse_colon] subset: efo_slim subset: human_reference_atlas subset: uberon_slim synonym: "colon transversum" EXACT OMO:0003011 [Wikipedia:Transverse_colon] xref: BTO:0000272 xref: CALOHA:TS-2052 xref: EFO:0000844 xref: EMAPA:35880 xref: FMA:14546 xref: galen:TransverseColon xref: MA:0001543 xref: MAT:0000312 xref: MIAA:0000312 xref: NCIT:C12385 xref: SCTID:362163004 xref: UMLS:C0227386 {source="ncithesaurus:Transverse_Colon"} xref: Wikipedia:Transverse_colon is_a: BFO:0000002 is_a: UBERON:0000168 {source="FMA"} ! proximal-distal subdivision of colon relationship: RO:0002150 UBERON:0001158 ! continuous with descending colon relationship: RO:0002202 UBERON:0001045 {source="Wikipedia"} ! develops from midgut property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/3/3b/Dickdarm-Schema.svg" xsd:anyURI property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/large-intestine-female/v1.3/assets/3d-sbu-f-large-intestine.glb" xsd:anyURI property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/large-intestine-male/v1.3/assets/3d-sbu-m-large-intestine.glb" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001158 name: descending colon def: "The portion of the colon between the left colic flexure and the sigmoid colon at the pelvic brim; the portion of the descending colon lying in the left iliac fossa is sometimes called the iliac colon." [BTO:0000641] subset: efo_slim subset: human_reference_atlas subset: uberon_slim synonym: "colon descendens" EXACT OMO:0003011 [Wikipedia:Descending_colon] xref: BTO:0000641 xref: CALOHA:TS-2010 xref: EFO:0000845 xref: EMAPA:35285 xref: FMA:14547 xref: galen:DescendingColon xref: MA:0001542 xref: MAT:0000313 xref: MIAA:0000313 xref: NCIT:C12268 xref: SCTID:362165006 xref: UMLS:C0227389 {source="ncithesaurus:Descending_Colon"} xref: Wikipedia:Descending_colon is_a: BFO:0000002 is_a: UBERON:0000168 {source="FMA"} ! proximal-distal subdivision of colon relationship: RO:0002150 UBERON:0001159 ! continuous with sigmoid colon relationship: RO:0002202 UBERON:0001046 {source="Wikipedia"} ! develops from hindgut property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/c/ca/Gray1223.png" xsd:anyURI property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/large-intestine-female/v1.3/assets/3d-sbu-f-large-intestine.glb" xsd:anyURI property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/large-intestine-male/v1.3/assets/3d-sbu-m-large-intestine.glb" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001159 name: sigmoid colon def: "The part of the large intestine that is closest to the rectum and anus. It forms a loop that averages about 40 cm. in length, and normally lies within the pelvis, but on account of its freedom of movement it is liable to be displaced into the abdominal cavity." [Wikipedia:Sigmoid_colon] subset: efo_slim subset: human_reference_atlas subset: uberon_slim synonym: "colon sigmoideum" RELATED OMO:0003011 [Wikipedia:Sigmoid_colon] synonym: "pelvic colon" RELATED [] synonym: "sigmoid colon" RELATED [] synonym: "sigmoid flexure" RELATED [] xref: BTO:0000645 xref: CALOHA:TS-2044 xref: EFO:0000846 xref: EMAPA:36391 xref: FMA:14548 xref: galen:SigmoidColon xref: MAT:0000314 xref: MESH:D012809 xref: MIAA:0000314 xref: NCIT:C12384 xref: NCIT:C33550 xref: SCTID:362166007 xref: UMLS:C0227391 {source="ncithesaurus:Sigmoid_Colon"} xref: UMLS:C0682612 {source="ncithesaurus:Sigmoid_Flexure"} xref: Wikipedia:Sigmoid_colon is_a: BFO:0000002 is_a: UBERON:0000168 {source="FMA"} ! proximal-distal subdivision of colon relationship: RO:0002150 UBERON:0001052 ! continuous with rectum relationship: RO:0002202 UBERON:0001046 {source="Wikipedia"} ! develops from hindgut property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/3/3b/Dickdarm-Schema.svg" xsd:anyURI property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/large-intestine-female/v1.3/assets/3d-sbu-f-large-intestine.glb" xsd:anyURI property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/large-intestine-male/v1.3/assets/3d-sbu-m-large-intestine.glb" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "sigmoid colon" xsd:string [Term] id: UBERON:0001160 name: fundus of stomach def: "The fundus is the portion of the stomach that lies above the cardiac notch, and contains the fundic glands[GO, Kardong]." [GO:0014825, ISBN:0073040584, Wikipedia:Fundus_(stomach)] subset: efo_slim subset: pheno_slim subset: uberon_slim synonym: "fundus gastricus" RELATED [BTO:0000502] synonym: "fundus gastricus (ventricularis)" EXACT [] synonym: "fundus gastricus ventricularis" RELATED [BTO:0000502] synonym: "fundus ventricularis" RELATED [BTO:0000502] synonym: "fundus ventriculi" RELATED [BTO:0000502] synonym: "gastric fundus" EXACT [] synonym: "stomach fundus" EXACT [] xref: BTO:0000502 xref: EFO:0002554 xref: EHDAA2:0001919 xref: EHDAA:4844 xref: EMAPA:17886 xref: FMA:14559 xref: GAID:320 xref: galen:GastricFundus xref: MA:0001612 xref: MESH:D005748 xref: NCIT:C12257 xref: SCTID:362139007 xref: UMLS:C0017129 {source="ncithesaurus:Fundus_of_the_Stomach"} xref: VHOG:0000421 xref: Wikipedia:Fundus_(stomach) is_a: BFO:0000002 is_a: UBERON:0009870 ! zone of stomach relationship: BFO:0000051 UBERON:0010038 ! has part fundic gastric gland relationship: RO:0002433 UBERON:0000945 ! contributes to morphology of stomach property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/3/31/Gray1046.svg" xsd:anyURI [Term] id: UBERON:0001161 name: body of stomach def: "The body of stomach is the part of the stomach that lies between the fundus above and the pyloric antrum below; its boundaries are poorly defined[GO]." [GO:0014845, Wikipedia:Body_of_stomach] subset: uberon_slim synonym: "corpus gastricum" RELATED OMO:0003011 [BTO:0000505, Wikipedia:Body_of_stomach] synonym: "corpus gastricum (ventriculare)" EXACT [] synonym: "corpus ventriculare" RELATED [BTO:0000505] synonym: "corpus ventriculi" RELATED [BTO:0000505] synonym: "gastric body" EXACT [] synonym: "gastric corpus" RELATED [] synonym: "stomach body" EXACT [] xref: BTO:0000505 xref: EMAPA:35810 xref: FMA:14560 xref: galen:GastricCorpus xref: MA:0002559 xref: NCIT:C12258 xref: SCTID:362140009 xref: UMLS:C0227230 {source="ncithesaurus:Body_of_Stomach"} xref: Wikipedia:Body_of_stomach is_a: UBERON:0009870 {source="FMA"} ! zone of stomach property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/3/31/Gray1046.svg" xsd:anyURI property_value: IAO:0000116 "we include this as zone of stomach even though it is not distinguished by gland type" xsd:string property_value: skos:prefLabel "body of stomach" xsd:string [Term] id: UBERON:0001162 name: cardia of stomach def: "The part of the stomach attached to the esophagus. The cardia begins immediately distal to the z-line of the gastroeosphageal junction, where the squamous epithelium of the esophagus gives way to the columnar epithelium of the gastrointestinal tract[WP]." [BTO:0000198, Wikipedia:Cardia] subset: pheno_slim synonym: "antrum cardiacum" RELATED OMO:0003011 [Wikipedia:Cardia] synonym: "cardiac antrum" RELATED [] synonym: "cardiac orifice" RELATED [Wikipedia:Cardia] synonym: "cardiac region" RELATED [Wikipedia:Cardia] synonym: "cardial orifice" RELATED [Wikipedia:Cardia] synonym: "cardial part of stomach" EXACT [] synonym: "gastric cardia" EXACT [] synonym: "pars cardiaca (gaster)" EXACT [] synonym: "pars cardiaca gastricae" EXACT OMO:0003011 [FMA:14561, FMA:TA] synonym: "stomach cardiac region" EXACT [MA:0001609] xref: BTO:0000198 xref: EMAPA:35811 xref: FMA:14561 xref: GAID:319 xref: MA:0001609 xref: MESH:D002299 xref: NCIT:C12256 xref: SCTID:362138004 xref: UMLS:C0007144 {source="ncithesaurus:Cardia"} xref: Wikipedia:Cardia is_a: UBERON:0009870 ! zone of stomach intersection_of: UBERON:0009870 ! zone of stomach intersection_of: BFO:0000051 UBERON:0008859 ! has part cardiac gastric gland relationship: BFO:0000051 UBERON:0008859 ! has part cardiac gastric gland relationship: RO:0002150 UBERON:0001043 ! continuous with esophagus relationship: RO:0002150 UBERON:0001161 ! continuous with body of stomach relationship: RO:0002433 UBERON:0000945 ! contributes to morphology of stomach property_value: foaf:depiction "https://upload.wikimedia.org/wikipedia/commons/3/33/Illu_stomach.jpg" xsd:anyURI property_value: IAO:0000116 "There were previously conflicting statements in the academic anatomy community[10][11][12] over whether the cardia is part of the stomach, part of the esophagus or a distinct entity. Modern surgical and medical textbooks have agreed that 'The gastric cardia is now clearly considered to be part of the stomach'[13][14]. Classical anatomy textbooks, and some other resources[15], describe the cardia as the first of 4 regions of the stomach. This makes sense histologically because the mucosa of the cardia is the same as that of the stomach[WP]" xsd:string property_value: IAO:0000116 "We follow Kardong in defining stomach regions by glands." xsd:string [Term] id: UBERON:0001165 name: pyloric antrum def: "The area at the bottom of the stomach on the caudal side of the pyloric canal that contains gastrin-producing G cells, which stimulate acid production, and the luminal pH-sensitive population of somatostatin-producing D cells." [ISBN:0-683-40008-8, MP:0010790] subset: efo_slim subset: pheno_slim subset: uberon_slim synonym: "antrum" BROAD [] synonym: "antrum of stomach" EXACT [] synonym: "antrum of Willis" RELATED [BTO:0001732] synonym: "antrum pylori" RELATED [BTO:0001732] synonym: "antrum pyloricum" RELATED OMO:0003011 [BTO:0001732, Wikipedia:Pyloric_antrum] synonym: "gastric antrum" RELATED [BTO:0001732] synonym: "stomach antrum" RELATED [] synonym: "stomach pyloric antrum" EXACT [] xref: BTO:0001732 xref: EFO:0002555 xref: EMAPA:17891 xref: FMA:14579 xref: GAID:332 xref: galen:PyloricAntrum xref: MA:0001624 xref: MESH:D011706 xref: NCIT:C12259 xref: SCTID:362142001 xref: UMLS:C0034193 {source="ncithesaurus:Antrum_Pylori"} xref: Wikipedia:Pyloric_antrum is_a: BFO:0000002 is_a: UBERON:0009870 {source="FMA"} ! zone of stomach relationship: BFO:0000050 UBERON:0001166 {source="Wikipedia"} ! part of pylorus relationship: BFO:0000051 CL:0000502 ! has part type D enteroendocrine cell relationship: BFO:0000051 CL:0000508 ! has part type G enteroendocrine cell relationship: RO:0002150 UBERON:0001161 ! continuous with body of stomach relationship: RO:0002433 UBERON:0001166 ! contributes to morphology of pylorus property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/3/31/Gray1046.svg" xsd:anyURI property_value: skos:prefLabel "pyloric antrum" xsd:string [Term] id: UBERON:0001166 name: pylorus def: "The stomach tissue region surrounding and controlling the distal outlet of the stomach, which opens into the duodenum." [MGI:csmith, MP:0010785] subset: pheno_slim subset: uberon_slim synonym: "pars pylorica" EXACT OMO:0003011 [] synonym: "pars pylorica gastricae" EXACT OMO:0003011 [FMA:14581, FMA:TA] synonym: "pyloric part of stomach" EXACT [] synonym: "pyloric region" EXACT [] synonym: "stomach pyloric region" EXACT [EHDAA2:0001580] synonym: "valvula pylori" RELATED OMO:0003011 [Wikipedia:Pylorus] xref: BTO:0001146 xref: EHDAA2:0001580 xref: EHDAA:4860 xref: EMAPA:17631 xref: FMA:14581 xref: GAID:333 xref: galen:Pylorus xref: MA:0002560 xref: MESH:D011708 xref: NCIT:C12260 xref: SCTID:362143006 xref: UMLS:C0034196 {source="ncithesaurus:Pylorus"} xref: VHOG:0000420 xref: Wikipedia:Pylorus is_a: BFO:0000002 is_a: UBERON:0009870 ! zone of stomach intersection_of: UBERON:0009870 ! zone of stomach intersection_of: BFO:0000051 UBERON:0001165 ! has part pyloric antrum intersection_of: BFO:0000051 UBERON:0008858 ! has part pyloric canal intersection_of: BFO:0000051 UBERON:0008861 ! has part pyloric gastric gland relationship: BFO:0000051 UBERON:0001165 ! has part pyloric antrum relationship: BFO:0000051 UBERON:0008858 ! has part pyloric canal relationship: BFO:0000051 UBERON:0008861 ! has part pyloric gastric gland relationship: RO:0002433 UBERON:0000945 ! contributes to morphology of stomach property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/3/31/Gray1046.svg" xsd:anyURI property_value: IAO:0000116 "We follow Kardong in defining stomach regions by glands" xsd:string property_value: skos:prefLabel "pylorus" xsd:string [Term] id: UBERON:0001167 name: wall of stomach def: "The layered structure that makes up the stomach, typiclly consists of a serous coat, a muscular coat, a mucous membrane, and other tissue layers in between." [MGI:csmith, MP:0010783] subset: pheno_slim synonym: "anatomical wall of stomach" EXACT [OBOL:automatic] synonym: "anatomical wall of ventriculus" EXACT [OBOL:automatic] synonym: "gastric wall" EXACT [] synonym: "stomach anatomical wall" EXACT [OBOL:automatic] synonym: "stomach wall" EXACT [] synonym: "ventriculus anatomical wall" EXACT [OBOL:automatic] synonym: "ventriculus wall" EXACT [OBOL:automatic] synonym: "wall of ventriculus" EXACT [OBOL:automatic] xref: EMAPA:35826 xref: FMA:14582 xref: galen:WallOfStomach xref: MA:0002692 xref: SCTID:279995000 is_a: UBERON:0000328 ! gut wall intersection_of: UBERON:0000060 ! anatomical wall intersection_of: BFO:0000050 UBERON:0000945 ! part of stomach relationship: BFO:0000050 UBERON:0000945 ! part of stomach relationship: RO:0002433 UBERON:0000945 ! contributes to morphology of stomach property_value: skos:prefLabel "wall of stomach" xsd:string [Term] id: UBERON:0001168 name: wall of small intestine def: "An anatomical wall that is part of a small intestine [Automatically generated definition]." [OBOL:automatic] synonym: "anatomical wall of small bowel" EXACT [OBOL:automatic] synonym: "anatomical wall of small intestine" EXACT [OBOL:automatic] synonym: "small bowel anatomical wall" EXACT [OBOL:automatic] synonym: "small bowel wall" EXACT [OBOL:automatic] synonym: "small intestinal wall" EXACT [] synonym: "small intestine anatomical wall" EXACT [OBOL:automatic] synonym: "small intestine wall" EXACT [] synonym: "wall of small bowel" EXACT [OBOL:automatic] xref: EMAPA:35785 xref: FMA:14615 xref: MA:0002696 xref: NCIT:C33573 xref: UMLS:C1519375 {source="ncithesaurus:Small_Intestinal_Wall_Tissue"} is_a: UBERON:0001262 ! wall of intestine intersection_of: UBERON:0000060 ! anatomical wall intersection_of: BFO:0000050 UBERON:0002108 ! part of small intestine relationship: BFO:0000050 UBERON:0002108 ! part of small intestine property_value: skos:prefLabel "wall of small intestine" xsd:string [Term] id: UBERON:0001169 name: wall of large intestine def: "An anatomical wall that is part of a large intestine [Automatically generated definition]." [OBOL:automatic] synonym: "anatomical wall of large intestine" EXACT [OBOL:automatic] synonym: "large intestinal wall" EXACT [] synonym: "large intestine anatomical wall" EXACT [OBOL:automatic] synonym: "large intestine wall" EXACT [] xref: EMAPA:35470 xref: FMA:14619 xref: MA:0002695 is_a: UBERON:0001262 ! wall of intestine intersection_of: UBERON:0000060 ! anatomical wall intersection_of: BFO:0000050 UBERON:0000059 ! part of large intestine relationship: BFO:0000050 UBERON:0000059 ! part of large intestine property_value: skos:prefLabel "wall of large intestine" xsd:string [Term] id: UBERON:0001170 name: mesentery of small intestine def: "The peritoneum responsible for connecting the jejunum and ileum (parts of the small intestine) to the back wall of the abdomen. Between the two sheets of peritoneum are blood vessels, lymph vessels, and nerves. This allows these parts of the small intestine to move relatively freely within the abdominopelvic cavity. The brain, however, cannot map sensation accurately, so sensation is usually referred to the midline, an example of referred pain[WP]." [Wikipedia:Mesentery#Mesentery_.28proper.29] synonym: "mesentery (proper)" EXACT [Wikipedia:Mesentery] synonym: "mesentery proper" EXACT [FMA:14643] synonym: "small intestinal mesentery" EXACT [FMA:14643] synonym: "small intestine mesentery" EXACT [OBOL:automatic] xref: EMAPA:37745 {source="MA:th"} xref: FMA:14643 xref: MA:0001555 xref: SCTID:245456008 xref: Wikipedia:Mesentery#Mesentery_.28proper.29 is_a: UBERON:0001206 ! serosa of small intestine is_a: UBERON:0004854 ! gastrointestinal system mesentery is_a: UBERON:0007826 {source="FMA"} ! peritoneal mesentery intersection_of: UBERON:0002095 ! mesentery intersection_of: BFO:0000050 UBERON:0002108 ! part of small intestine [Term] id: UBERON:0001171 name: portal lobule def: "The triangular region on the periphery of the liver lobules that contain a bile duct and a terminal branch of the hepatic artery and portal vein, and may also include a lymphatic vessel." [MP:0008992] subset: pheno_slim xref: FMA:14653 xref: MA:0002498 xref: NCIT:C33341 xref: UMLS:C0682620 {source="ncithesaurus:Portal_Lobule"} is_a: UBERON:0009911 {source="FMA"} ! lobule relationship: BFO:0000050 UBERON:0001280 {source="MA", source="MP"} ! part of liver parenchyma relationship: RO:0002433 UBERON:0001280 ! contributes to morphology of liver parenchyma property_value: skos:prefLabel "portal lobule" xsd:string [Term] id: UBERON:0001172 name: hepatic acinus def: "The functional unit of the liver, consisting of a mass of hepatocytes from adjacent liver lobules aligned around the hepatic arterioles and portal venules just as they anastomose into sinusoids." [http://orcid.org/0000-0002-6601-2165, http://www.vivo.colostate.edu/hbooks/pathphys/digestion/liver/histo_acinus.html] synonym: "liver acinus" EXACT [] synonym: "portal acinus" EXACT [] xref: EMAPA:35497 xref: FMA:14654 xref: MA:0002496 xref: NCIT:C32992 xref: SCTID:272214009 xref: UMLS:C0227519 {source="ncithesaurus:Liver_Acinus"} is_a: UBERON:0011858 ! acinus of exocrine gland relationship: BFO:0000050 UBERON:0001280 {source="cjm"} ! part of liver parenchyma relationship: RO:0002131 UBERON:0001171 ! overlaps portal lobule relationship: RO:0002131 UBERON:0004647 ! overlaps liver lobule property_value: skos:prefLabel "hepatic acinus" xsd:string [Term] id: UBERON:0001173 name: biliary tree def: "A complex network of conduits that begins with the canals of Hering (intralobar bile duct) and progressively merges into a system of interlobular, septal, and major ducts which then coalesce to form the extrahepatic bile ducts, which finally deliver bile to the intestine, and in some species to the gallbladder." [DOI:10.1002/ar.20664] comment: The path in many species is as follows: Bile canaliculi -> Canals of Hering (intralobar bile duct) -> interlobular bile ducts -> intrahepatic bile ducts -> left and right hepatic ducts merge to form -> common hepatic duct *exits liver* and joins -> cystic duct (from gall bladder) forming -> common bile duct -> joins with pancreatic duct -> forming ampulla of Vater -> enters duodenum [WP] subset: organ_slim subset: pheno_slim subset: uberon_slim synonym: "biliary tract" RELATED [MA:0001273] xref: AAO:0011020 xref: EMAPA:35172 xref: FMA:14665 xref: MESH:D001659 {sssom:mapping_justification="https://w3id.org/semapv/vocab/LexicalMatching"} xref: SCTID:181267003 xref: UMLS:C0005423 {source="ncithesaurus:Biliary_Tract"} xref: Wikipedia:Biliary_tract xref: XAO:0000455 is_a: UBERON:0004119 ! endoderm-derived structure is_a: UBERON:0013765 ! digestive system element intersection_of: UBERON:0000062 ! organ intersection_of: BFO:0000050 UBERON:0002294 ! part of biliary system intersection_of: RO:0002473 UBERON:0002394 ! composed primarily of bile duct relationship: BFO:0000050 UBERON:0002294 ! part of biliary system relationship: BFO:0000051 UBERON:0001246 ! has part interlobular bile duct relationship: BFO:0000051 UBERON:0001282 ! has part intralobular bile duct relationship: BFO:0000051 UBERON:0003703 ! has part extrahepatic bile duct relationship: RO:0002202 UBERON:0004912 ! develops from biliary bud relationship: RO:0002433 UBERON:0002423 ! contributes to morphology of hepatobiliary system relationship: RO:0002473 UBERON:0002394 ! composed primarily of bile duct property_value: skos:prefLabel "biliary tree" xsd:string [Term] id: UBERON:0001174 name: common bile duct def: "The part of the biliary tree formed by the union of the cystic duct and the common hepatic duct." [MGI:csmith, MP:0009495] subset: human_reference_atlas subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "ductus choledochus" RELATED OMO:0003011 [Wikipedia:Common_bile_duct] synonym: "ductus choledochus (biliaris)" EXACT [] xref: EHDAA2:0000303 xref: EHDAA:3981 xref: EMAPA:17201 xref: FMA:14667 xref: GAID:282 xref: galen:CommonBileDuct xref: MA:0001631 xref: MESH:D003135 xref: NCIT:C12698 xref: SCTID:362199009 xref: TAO:0005165 xref: UMLS:C0009437 {source="ncithesaurus:Common_Bile_Duct"} xref: VHOG:0000214 xref: Wikipedia:Common_bile_duct xref: ZFA:0005165 is_a: UBERON:0003703 ! extrahepatic bile duct relationship: channels_into UBERON:0001064 ! ventral pancreatic duct relationship: RO:0002150 UBERON:0001152 ! continuous with cystic duct relationship: RO:0002150 UBERON:0001175 ! continuous with common hepatic duct property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/5/5d/Digestive_system_showing_bile_duct.png" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "common bile duct" xsd:string [Term] id: UBERON:0001175 name: common hepatic duct def: "Predominantly extrahepatic bile duct which is formed by the junction of the right and left hepatic ducts, which are predominantly intrahepatic, and, in turn, joins the cystic duct to form the common bile duct[GAID]. The common hepatic duct is the duct formed by the convergence of the right hepatic duct (which drains bile from the right functional lobe of the liver) and the left hepatic duct (which drains bile from the left functional lobe of the liver). The common hepatic duct then joins the cystic duct coming from the gallbladder to form the common bile duct[WP]." [Wikipedia:Common_hepatic_duct, ZFIN:curator] subset: pheno_slim subset: uberon_slim synonym: "ductus hepaticus communis" RELATED OMO:0003011 [Wikipedia:Common_hepatic_duct] synonym: "hepatic duct" RELATED [] xref: EMAPA:19101 xref: FMA:14668 xref: GAID:286 xref: MA:0002660 xref: MESH:D006500 xref: NCIT:C32356 xref: SCTID:245403006 xref: UMLS:C0019149 {source="ncithesaurus:Common_Hepatic_Duct"} xref: VHOG:0000220 xref: Wikipedia:Common_hepatic_duct is_a: UBERON:0003703 {source="FMA"} ! extrahepatic bile duct relationship: BFO:0000050 UBERON:0005604 {source="MA"} ! part of extrahepatic part of hepatic duct relationship: channels_into UBERON:0001174 ! common bile duct relationship: RO:0002150 UBERON:0001176 {source="Wikipedia"} ! continuous with right hepatic duct relationship: RO:0002150 UBERON:0001177 {source="Wikipedia"} ! continuous with left hepatic duct relationship: RO:0002495 UBERON:0010081 {evidence="definitional"} ! immediate transformation of future common hepatic duct property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/4/48/Illu_liver_gallbladder.jpg" xsd:anyURI property_value: IAO:0000116 "TODO - MA distinguishes between bile duct, hepatic duct, common bile duct and common hepatic duct. in FMA hepatic duct and common hepatic duct are the same. Common is part of extra-hepatic part" xsd:string property_value: skos:prefLabel "common hepatic duct" xsd:string [Term] id: UBERON:0001176 name: right hepatic duct def: "The duct that drains bile from the right half of the liver and joins the left hepatic duct to form the common hepatic duct." [http://www.medterms.com/script/main/art.asp?articlekey=26034] synonym: "ductus hepaticus dexter" RELATED OMO:0003011 [] xref: EHDAA2:0001727 xref: EHDAA:3992 xref: EMAPA:32797 xref: FMA:14669 xref: MA:0001639 xref: NCIT:C33476 xref: SCTID:245401008 xref: UMLS:C0227557 {source="ncithesaurus:Right_Hepatic_Duct"} xref: VHOG:0000217 is_a: UBERON:0003703 ! extrahepatic bile duct intersection_of: UBERON:0003703 ! extrahepatic bile duct intersection_of: RO:0002150 UBERON:0001114 ! continuous with right lobe of liver relationship: BFO:0000050 UBERON:0005171 ! part of hepatic duct relationship: RO:0002150 UBERON:0001114 ! continuous with right lobe of liver property_value: skos:prefLabel "right hepatic duct" xsd:string [Term] id: UBERON:0001177 name: left hepatic duct def: "The duct that drains bile from the left half of the liver and joins the right hepatic duct to form the common hepatic duct." [http://www.medterms.com/script/main/art.asp?articlekey=26035] synonym: "ductus hepaticus sinister" RELATED OMO:0003011 [] xref: EHDAA2:0000941 xref: EHDAA:3990 xref: EMAPA:32795 xref: FMA:14670 xref: MA:0001638 xref: NCIT:C32960 xref: SCTID:245400009 xref: UMLS:C0227560 {source="ncithesaurus:Left_Hepatic_Duct"} xref: VHOG:0000218 is_a: UBERON:0003703 ! extrahepatic bile duct intersection_of: UBERON:0003703 ! extrahepatic bile duct intersection_of: RO:0002150 UBERON:0001115 ! continuous with left lobe of liver relationship: BFO:0000050 UBERON:0005171 ! part of hepatic duct relationship: RO:0002150 UBERON:0001115 ! continuous with left lobe of liver property_value: skos:prefLabel "left hepatic duct" xsd:string [Term] id: UBERON:0001178 name: visceral peritoneum def: "The inner layer of peritoneum that is wrapped around organs located inside the intraperitoneal space." [http://orcid.org/0000-0002-6601-2165, Wikipedia:Peritoneum#Types] subset: uberon_slim subset: vertebrate_core synonym: "visceral serous membrane of peritoneum" EXACT [UBERON:cjm] xref: EMAPA:16592 xref: FMA:14703 xref: SCTID:362702003 xref: TAO:0005132 xref: VHOG:0001528 xref: Wikipedia:Visceral_peritoneum xref: ZFA:0005132 is_a: UBERON:0022350 ! visceral serous membrane intersection_of: UBERON:0022350 ! visceral serous membrane intersection_of: BFO:0000050 UBERON:0002358 ! part of peritoneum relationship: BFO:0000050 UBERON:0002358 ! part of peritoneum property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/5/5f/Gray1040.png" xsd:anyURI property_value: skos:prefLabel "visceral peritoneum" xsd:string [Term] id: UBERON:0001179 name: peritoneal cavity def: "Anatomical cavity bounded by visceral and parietal peritoneum." [http://orcid.org/0000-0002-6601-2165, https://github.com/obophenotype/uberon/issues/86, Wikipedia:Peritoneal_cavity] subset: pheno_slim subset: uberon_slim synonym: "cavitas peritonealis" RELATED OMO:0003011 [BTO:0001782, Wikipedia:Peritoneal_cavity] synonym: "saccus serosus peritonei" RELATED OMO:0003011 [Wikipedia:Peritoneal_cavity] xref: BTO:0001782 xref: EHDAA2:0001446 xref: EMAPA:16138 xref: FMA:14704 xref: GAID:24 xref: MA:0000054 xref: MESH:D010529 xref: NCIT:C12769 xref: SCTID:181616008 xref: UMLS:C1704247 {source="ncithesaurus:Peritoneal_Cavity"} xref: VHOG:0000852 xref: Wikipedia:Peritoneal_cavity is_a: BFO:0000002 is_a: UBERON:0035809 ! serous cavity intersection_of: UBERON:0002553 ! anatomical cavity intersection_of: RO:0002220 UBERON:0001178 ! adjacent to visceral peritoneum intersection_of: RO:0002220 UBERON:0001366 ! adjacent to parietal peritoneum intersection_of: RO:0002572 UBERON:0035820 ! luminal space of peritoneal sac relationship: RO:0002202 UBERON:0003887 {source="Wikipedia"} ! develops from intraembryonic coelom relationship: RO:0002220 UBERON:0001178 ! adjacent to visceral peritoneum relationship: RO:0002220 UBERON:0001366 ! adjacent to parietal peritoneum relationship: RO:0002572 UBERON:0035820 ! luminal space of peritoneal sac property_value: skos:prefLabel "peritoneal cavity" xsd:string [Term] id: UBERON:0001182 name: superior mesenteric artery def: "Mesenteric artery that supplies the whole length of the small intestine except the superior part of the duodenum. It also supplies the cecum and the ascending part of the colon and about half the transverse part of the colon. It arises from the anterior surface of the aorta below the celiac artery at the level of the first lumbar vertebra." [MESH:A07.231.114.565.755] subset: human_reference_atlas subset: pheno_slim subset: uberon_slim synonym: "arteria mesenterica superior" RELATED OMO:0003011 [BTO:0002303, Wikipedia:Superior_mesenteric_artery] synonym: "superior mesenteric arterial tree" EXACT [] xref: BTO:0002303 xref: EHDAA2:0001949 xref: EHDAA:3358 xref: EHDAA:5313 xref: EMAPA:18619 xref: FMA:14749 xref: GAID:502 xref: galen:SuperiorMesentericArtery xref: MA:0002005 xref: MESH:D017538 xref: NCIT:C33685 xref: SCTID:362048004 xref: UMLS:C0162861 {source="ncithesaurus:Superior_Mesenteric_Artery"} xref: VHOG:0000754 xref: Wikipedia:Superior_mesenteric_artery is_a: UBERON:0005616 ! mesenteric artery intersection_of: UBERON:0005616 ! mesenteric artery intersection_of: RO:0020101 UBERON:0002115 ! vessel supplies blood to jejunum intersection_of: RO:0020101 UBERON:0002116 ! vessel supplies blood to ileum relationship: RO:0020101 UBERON:0002115 ! vessel supplies blood to jejunum relationship: RO:0020101 UBERON:0002116 ! vessel supplies blood to ileum property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/6/68/Gray1099.png" xsd:anyURI property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/c/c0/Superior_mesenteric_a.gif" xsd:anyURI property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/blood-vasculature-female/v1.3/assets/3d-vh-f-blood-vasculature.glb" xsd:anyURI property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/blood-vasculature-male/v1.3/assets/3d-vh-m-blood-vasculature.glb" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001183 name: inferior mesenteric artery def: "Mesenteric artery that supplies the large intestine from the left colic (or splenic) flexure to the upper part of the rectum, which includes the descending colon, the sigmoid colon, and part of the rectum. Proximally, its territory of distribution overlaps (forms a watershed) with the middle colic artery, and therefore the superior mesenteric artery. The SMA and IMA anastomose via the marginal artery (artery of Drummond). The territory of distribution of the IMA is more or less equivalent to the embryonic hindgut. [WP,unvetted]." [Wikipedia:Inferior_mesenteric_artery] subset: human_reference_atlas subset: pheno_slim subset: uberon_slim synonym: "arteria mesenterica inferior" RELATED OMO:0003011 [BTO:0002302, Wikipedia:Inferior_mesenteric_artery] synonym: "IMA" BROAD OMO:0003000 [] synonym: "inferior mesenteric arterial tree" EXACT [] xref: BTO:0002302 xref: EHDAA2:0000817 xref: EHDAA:4345 xref: EMAPA:18618 xref: FMA:14750 xref: GAID:501 xref: galen:InferiorMesentericArtery xref: MA:0002004 xref: MESH:D017537 xref: NCIT:C32780 xref: SCTID:181341006 xref: UMLS:C0162860 {source="ncithesaurus:Inferior_Mesenteric_Artery"} xref: VHOG:0001116 xref: Wikipedia:Inferior_mesenteric_artery is_a: UBERON:0005616 ! mesenteric artery is_a: UBERON:0035039 ! rectal artery intersection_of: UBERON:0005616 ! mesenteric artery intersection_of: RO:0020101 UBERON:0001052 ! vessel supplies blood to rectum intersection_of: RO:0020101 UBERON:0001158 ! vessel supplies blood to descending colon intersection_of: RO:0020101 UBERON:0001159 ! vessel supplies blood to sigmoid colon relationship: RO:0020101 UBERON:0001158 ! vessel supplies blood to descending colon relationship: RO:0020101 UBERON:0001159 ! vessel supplies blood to sigmoid colon property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/e/e4/Gray538.png" xsd:anyURI property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/blood-vasculature-female/v1.3/assets/3d-vh-f-blood-vasculature.glb" xsd:anyURI property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/blood-vasculature-male/v1.3/assets/3d-vh-m-blood-vasculature.glb" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001184 name: renal artery def: "One of two laterally paired arteries that supplies the kidneys. These are large arteries that branch from the dorsal aorta in primitive vertebrates." [ISBN:0073040584, Wikipedia:Renal_artery] subset: efo_slim subset: human_reference_atlas subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "arteria renalis" RELATED OMO:0003011 [Wikipedia:Renal_artery] synonym: "renal arterial tree" EXACT [] synonym: "renal arteries" RELATED OMO:0003004 [] xref: AAO:0010223 xref: BTO:0001165 xref: EFO:0002552 xref: EHDAA2:0004100 xref: EHDAA:5321 xref: EHDAA:8594 xref: EMAPA:28373 xref: FMA:14751 xref: GAID:507 xref: galen:RenalArtery xref: MA:0002035 xref: MESH:D012077 xref: NCIT:C12778 xref: RETIRED_EHDAA2:0001600 xref: SCTID:181339005 xref: TAO:0000420 xref: UMLS:C0035065 {source="ncithesaurus:Renal_Artery"} xref: Wikipedia:Renal_artery xref: ZFA:0000420 is_a: UBERON:0012254 ! abdominal aorta artery intersection_of: UBERON:0001637 ! artery intersection_of: RO:0020101 UBERON:0002113 ! vessel supplies blood to kidney relationship: RO:0020101 UBERON:0002113 ! vessel supplies blood to kidney property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/d/da/Gray1120.png" xsd:anyURI property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/blood-vasculature-female/v1.3/assets/3d-vh-f-blood-vasculature.glb" xsd:anyURI property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/blood-vasculature-male/v1.3/assets/3d-vh-m-blood-vasculature.glb" xsd:anyURI property_value: IAO:0000116 "renal arteries vary widely even in humans. Sub-structures should be checked for taxon variability." xsd:string property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001185 name: right renal artery def: "Renal artery that supplies the right kidney." [https://orcid.org/0000-0002-6601-2165] comment: The right [renal artery] passes behind the inferior vena cava, the right renal vein, the head of the pancreas, and the descending part of the duodenum[WP] subset: human_reference_atlas subset: pheno_slim subset: uberon_slim synonym: "right renal arterial tree" EXACT [] xref: EMAPA:37380 {source="MA:th"} xref: FMA:14752 xref: MA:0002037 xref: NCIT:C52740 xref: SCTID:36800007 xref: UMLS:C0226332 {source="ncithesaurus:Right_Renal_Artery"} is_a: UBERON:0001184 ! renal artery intersection_of: UBERON:0001184 ! renal artery intersection_of: RO:0020101 UBERON:0004539 ! vessel supplies blood to right kidney relationship: RO:0020101 UBERON:0004539 ! vessel supplies blood to right kidney property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/d/da/Gray1120.png" xsd:anyURI property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/blood-vasculature-female/v1.3/assets/3d-vh-f-blood-vasculature.glb" xsd:anyURI property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/blood-vasculature-male/v1.3/assets/3d-vh-m-blood-vasculature.glb" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001186 name: left renal artery def: "Renal artery that supplies the left kidney." [https://orcid.org/0000-0002-6601-2165] comment: The left [renal artery] is somewhat higher than the right; it lies behind the left renal vein, the body of the pancreas and the splenic vein, and is crossed by the inferior mesenteric vein[WP] subset: human_reference_atlas subset: pheno_slim synonym: "left renal arterial tree" EXACT [] xref: EMAPA:37098 {source="MA:th"} xref: FMA:14753 xref: MA:0002036 xref: NCIT:C52741 xref: SCTID:19215005 xref: UMLS:C0226333 {source="ncithesaurus:Left_Renal_Artery"} is_a: UBERON:0001184 ! renal artery intersection_of: UBERON:0001184 ! renal artery intersection_of: RO:0020101 UBERON:0004538 ! vessel supplies blood to left kidney relationship: RO:0020101 UBERON:0004538 ! vessel supplies blood to left kidney property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/blood-vasculature-female/v1.3/assets/3d-vh-f-blood-vasculature.glb" xsd:anyURI property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/blood-vasculature-male/v1.3/assets/3d-vh-m-blood-vasculature.glb" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001187 name: testicular artery def: "One of a pair of arteries that is a branch of the abdominal aorta that supplies blood to a male gonad." [http://orcid.org/0000-0002-6601-2165, Wikipedia:Testicular_artery] subset: human_reference_atlas subset: uberon_slim synonym: "arteria testicularis" RELATED OMO:0003011 [Wikipedia:Testicular_artery] synonym: "internal spermatic" RELATED [Wikipedia:Testicular_artery] synonym: "internal spermatic arteries" RELATED [Wikipedia:Testicular_artery] synonym: "internal spermatic artery" RELATED [Wikipedia:Testicular_artery] synonym: "internal spermatic vessels" RELATED [Wikipedia:Testicular_artery] synonym: "spermatic arteries" RELATED [Wikipedia:Testicular_artery] synonym: "spermatic artery" RELATED [Wikipedia:Testicular_artery] synonym: "spermatic vessels" RELATED [Wikipedia:Testicular_artery] synonym: "testicular arterial tree" EXACT [] synonym: "testicular arteries" RELATED [Wikipedia:Testicular_artery] xref: EMAPA:18621 xref: FMA:14758 xref: MA:0002063 xref: SCTID:244281003 xref: Wikipedia:Testicular_artery is_a: UBERON:0010192 ! genital artery intersection_of: UBERON:0001637 ! artery intersection_of: RO:0020101 UBERON:0000473 ! vessel supplies blood to testis relationship: RO:0020101 UBERON:0000473 ! vessel supplies blood to testis property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/a/af/Gray531.png" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001188 name: right testicular artery def: "A testicular artery that supplies a right testicle." [OBOL:automatic] subset: human_reference_atlas synonym: "right spermatic artery" EXACT [] synonym: "trunk of right testicular arterial tree" EXACT [] xref: EMAPA:37382 {source="MA:th"} xref: FMA:14759 xref: MA:0002042 xref: NCIT:C52738 xref: UMLS:C0734076 {source="ncithesaurus:Right_Spermatic_Artery"} is_a: UBERON:0001187 ! testicular artery is_a: UBERON:0003468 ! ureteric segment of renal artery intersection_of: UBERON:0001187 ! testicular artery intersection_of: RO:0020101 UBERON:0004534 ! vessel supplies blood to right testis relationship: RO:0020101 UBERON:0001222 ! vessel supplies blood to right ureter relationship: RO:0020101 UBERON:0004534 ! vessel supplies blood to right testis property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001189 name: left testicular artery def: "A testicular artery that supplies a left testicle." [OBOL:automatic] subset: human_reference_atlas synonym: "left spermatic artery" EXACT [] synonym: "trunk of left testicular arterial tree" EXACT [] xref: EMAPA:37099 {source="MA:th"} xref: FMA:14760 xref: MA:0002041 xref: NCIT:C52739 xref: UMLS:C0734077 {source="ncithesaurus:Left_Spermatic_Artery"} is_a: UBERON:0001187 ! testicular artery is_a: UBERON:0003468 ! ureteric segment of renal artery intersection_of: UBERON:0001187 ! testicular artery intersection_of: RO:0020101 UBERON:0004533 ! vessel supplies blood to left testis relationship: RO:0020101 UBERON:0001223 ! vessel supplies blood to left ureter relationship: RO:0020101 UBERON:0004533 ! vessel supplies blood to left testis property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001190 name: ovarian artery def: "An artery that supplies an ovary." [OBOL:automatic] subset: human_reference_atlas subset: uberon_slim synonym: "arteria ovarica" RELATED OMO:0003011 [Wikipedia:Ovarian_artery] synonym: "ovarian arterial tree" EXACT [] xref: EMAPA:18620 xref: FMA:14761 xref: MA:0002012 xref: NCIT:C33242 xref: SCTID:244280002 xref: UMLS:C0226411 {source="ncithesaurus:Ovarian_Artery"} xref: Wikipedia:Ovarian_artery is_a: UBERON:0001637 ! artery intersection_of: UBERON:0001637 ! artery intersection_of: RO:0020101 UBERON:0000992 ! vessel supplies blood to ovary relationship: RO:0002170 UBERON:0001516 ! connected to abdominal aorta relationship: RO:0020101 UBERON:0000992 ! vessel supplies blood to ovary property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/a/ae/Gray1170.png" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "ovarian artery" xsd:string [Term] id: UBERON:0001191 name: common iliac artery def: "The common iliac arteries are two large arteries, about 4cm long in adults but more than a centimetre in diameter, that originate from the aortic bifurcation. The arteries run inferolaterally, along the medial border of the psoas muscles to the pelvic brim, where they bifurcate into the external iliac artery and internal iliac artery. The common iliac artery, and all of its branches, exist as paired structures (that is to say, there is one on the left side and one on the right). The distribution of the common iliac artery is basically the pelvis and lower limb on the corresponding side. Both common iliac arteries are accompanied along their course by common iliac veins. [WP,unvetted]." [Wikipedia:Common_iliac_artery] comment: See notes for parent class subset: human_reference_atlas subset: uberon_slim synonym: "arteria iliaca communis" RELATED OMO:0003011 [Wikipedia:Common_iliac_artery] synonym: "common iliac arterial tree" EXACT [] xref: EHDAA2:0000311 xref: EHDAA:2553 xref: EMAPA:17310 xref: FMA:14764 xref: MA:0001972 xref: NCIT:C32357 xref: SCTID:362050007 xref: UMLS:C1261084 {source="ncithesaurus:Common_Iliac_Artery"} xref: Wikipedia:Common_iliac_artery is_a: UBERON:0005609 {source="MA"} ! iliac artery is_a: UBERON:0012254 ! abdominal aorta artery property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/6/6e/Iliac_artery_bifurcation_and_aorta.PNG" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001193 name: hepatic artery def: "An artery that supplies the liver." [https://orcid.org/0000-0002-6601-2165, Wikipedia:Hepatic_artery_proper] subset: human_reference_atlas subset: uberon_slim subset: vertebrate_core synonym: "arteria hepatica" RELATED [BTO:0004307] synonym: "arteria hepatica propria" EXACT OMO:0003011 [] xref: BTO:0004307 xref: EMAPA:17859 xref: FMA:14769 xref: GAID:496 xref: galen:HepaticArtery xref: MA:0001963 xref: MESH:D006499 xref: NCIT:C32729 xref: SCTID:76015000 xref: TAO:0005161 xref: UMLS:C0019145 {source="ncithesaurus:Hepatic_Artery"} xref: ZFA:0005161 is_a: UBERON:0001637 ! artery intersection_of: UBERON:0001637 ! artery intersection_of: RO:0020101 UBERON:0002107 ! vessel supplies blood to liver relationship: RO:0020101 UBERON:0002107 ! vessel supplies blood to liver property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/4/4c/Common_and_proper_hepatic_artery.png" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "hepatic artery" xsd:string [Term] id: UBERON:0001194 name: splenic artery def: "An artery that supplies the spleen." [http://orcid.org/0000-0002-6601-2165] subset: human_reference_atlas subset: uberon_slim synonym: "arteria lienalis" RELATED OMO:0003011 [Wikipedia:Splenic_artery] synonym: "arteria splenica" EXACT OMO:0003011 [Wikipedia:Splenic_artery] synonym: "lienal artery" EXACT [MA:0001991] xref: EMAPA:19216 xref: FMA:14773 xref: GAID:510 xref: galen:SplenicArtery xref: MA:0001991 xref: MA:0003177 xref: MESH:D013157 xref: NCIT:C33597 xref: SCTID:244266009 xref: UMLS:C0037996 {source="ncithesaurus:Splenic_Artery"} xref: Wikipedia:Splenic_artery is_a: UBERON:0001637 ! artery intersection_of: UBERON:0001637 ! artery intersection_of: RO:0020101 UBERON:0002106 ! vessel supplies blood to spleen disjoint_from: UBERON:0001640 ! celiac artery relationship: RO:0002252 UBERON:0001640 ! connecting branch of celiac artery relationship: RO:0020101 UBERON:0002106 ! vessel supplies blood to spleen property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/a/a2/Gray1188.png" xsd:anyURI property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/blood-vasculature-female/v1.3/assets/3d-vh-f-blood-vasculature.glb" xsd:anyURI property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/blood-vasculature-male/v1.3/assets/3d-vh-m-blood-vasculature.glb" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 property_value: seeAlso "https://github.com/obophenotype/uberon/issues/268" xsd:anyURI property_value: skos:prefLabel "splenic artery" xsd:string [Term] id: UBERON:0001196 name: middle colic artery def: "The middle colic artery is a branch of the superior mesenteric artery that mostly supplies the transverse colon. It arises just below the pancreas, and, passing downward and forward between the layers of the transverse mesocolon, divides into two branches: right and left. The right branch anastomoses with the right colic artery The left branch anastomoses with the left colic artery, a branch of the inferior mesenteric artery. The arches thus formed are placed about two fingers' breadth from the transverse colon, to which they distribute branches. [WP,unvetted]." [Wikipedia:Middle_colic_artery] subset: human_reference_atlas subset: uberon_slim synonym: "arteria colica media" RELATED OMO:0003011 [Wikipedia:Middle_colic_artery] xref: EMAPA:37106 {source="MA:th"} xref: FMA:14810 xref: galen:MiddleColicArtery xref: MA:0002007 xref: NCIT:C52981 xref: SCTID:244276007 xref: UMLS:C0226328 {source="ncithesaurus:Middle_Colic_Artery"} xref: Wikipedia:Middle_colic_artery is_a: UBERON:0001637 ! artery intersection_of: UBERON:0001637 ! artery intersection_of: RO:0002252 UBERON:0001182 ! connecting branch of superior mesenteric artery intersection_of: RO:0020101 UBERON:0001157 ! vessel supplies blood to transverse colon relationship: RO:0002252 UBERON:0001182 ! connecting branch of superior mesenteric artery relationship: RO:0020101 UBERON:0001157 ! vessel supplies blood to transverse colon property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/c/cb/Gray537.png" xsd:anyURI property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/blood-vasculature-female/v1.3/assets/3d-vh-f-blood-vasculature.glb" xsd:anyURI property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/blood-vasculature-male/v1.3/assets/3d-vh-m-blood-vasculature.glb" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001197 name: ileocolic artery def: "The Ileocolic Artery is the lowest branch arising from the concavity of the superior mesenteric artery. It passes downward and to the right behind the peritoneum toward the right iliac fossa, where it divides into a superior and an inferior branch; the inferior anastomoses with the end of the superior mesenteric artery, the superior with the right colic artery. Supplies the cecum, ileum, and appendix. [WP,unvetted]." [Wikipedia:Ileocolic_artery] subset: human_reference_atlas subset: uberon_slim synonym: "arteria ileocolica" RELATED OMO:0003011 [Wikipedia:Ileocolic_artery] xref: EMAPA:37083 {source="MA:th"} xref: FMA:14815 xref: galen:IleocolicArtery xref: MA:0001970 xref: NCIT:C32760 xref: SCTID:244279000 xref: UMLS:C0226323 {source="ncithesaurus:Ileo-colic_Artery"} xref: Wikipedia:Ileocolic_artery is_a: UBERON:0001637 ! artery intersection_of: UBERON:0001637 ! artery intersection_of: RO:0002252 UBERON:0001182 ! connecting branch of superior mesenteric artery intersection_of: RO:0020101 UBERON:0001153 ! vessel supplies blood to caecum intersection_of: RO:0020101 UBERON:0001154 ! vessel supplies blood to vermiform appendix intersection_of: RO:0020101 UBERON:0002116 ! vessel supplies blood to ileum relationship: RO:0002252 UBERON:0001182 ! connecting branch of superior mesenteric artery relationship: RO:0020101 UBERON:0001153 ! vessel supplies blood to caecum relationship: RO:0020101 UBERON:0001154 ! vessel supplies blood to vermiform appendix relationship: RO:0020101 UBERON:0002116 ! vessel supplies blood to ileum property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/a/ad/Gray536.png" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001199 name: mucosa of stomach def: "The mucosal layer that lines the stomach." [http://orcid.org/0000-0002-6601-2165] subset: pheno_slim subset: uberon_slim synonym: "gastric mucosa" EXACT [] synonym: "gastric mucous membrane" EXACT [] synonym: "Magenschleimhaut" RELATED [BTO:0001308] synonym: "mucosa of organ of stomach" EXACT [OBOL:automatic] synonym: "mucosa of organ of ventriculus" EXACT [OBOL:automatic] synonym: "mucosa of ventriculus" EXACT [OBOL:automatic] synonym: "mucous membrane of stomach" EXACT [] synonym: "mucous membrane of ventriculus" EXACT [OBOL:automatic] synonym: "organ mucosa of stomach" EXACT [OBOL:automatic] synonym: "organ mucosa of ventriculus" EXACT [OBOL:automatic] synonym: "stomach mucosa" EXACT [] synonym: "stomach mucosa of organ" EXACT [OBOL:automatic] synonym: "stomach mucous membrane" EXACT [OBOL:automatic] synonym: "stomach organ mucosa" EXACT [OBOL:automatic] synonym: "tunica mucosa (gaster)" EXACT [] synonym: "tunica mucosa gastricae" EXACT OMO:0003011 [FMA:14907, FMA:TA] synonym: "tunica mucosa gastris" RELATED OMO:0003011 [BTO:0001308, Wikipedia:Gastric_mucosa] synonym: "ventriculus mucosa" EXACT [OBOL:automatic] synonym: "ventriculus mucosa of organ" EXACT [OBOL:automatic] synonym: "ventriculus mucous membrane" EXACT [OBOL:automatic] synonym: "ventriculus organ mucosa" EXACT [OBOL:automatic] xref: BTO:0001308 xref: CALOHA:TS-0404 xref: EMAPA:35817 xref: FMA:14907 xref: GAID:321 xref: galen:GastricMucosa xref: MA:0002683 xref: MESH:D005753 xref: NCIT:C32656 xref: SCTID:362131005 xref: UMLS:C0017136 {source="ncithesaurus:Gastric_Mucosa"} xref: Wikipedia:Gastric_mucosa is_a: UBERON:0004786 ! gastrointestinal system mucosa intersection_of: UBERON:0000344 ! mucosa intersection_of: BFO:0000050 UBERON:0000945 ! part of stomach relationship: BFO:0000050 UBERON:0001167 ! part of wall of stomach relationship: RO:0002215 GO:0001696 ! capable of gastric acid secretion relationship: RO:0002433 UBERON:0001167 ! contributes to morphology of wall of stomach property_value: foaf:depiction "https://upload.wikimedia.org/wikipedia/commons/1/1c/Normal_gastric_mucosa_intermed_mag.jpg" xsd:anyURI property_value: skos:prefLabel "mucosa of stomach" xsd:string [Term] id: UBERON:0001200 name: submucosa of stomach def: "The fibrous connective tissue layer beneath the stomach mucosa." [MGI:csmith, MP:0010794] subset: pheno_slim synonym: "gastric submucosa" EXACT [] synonym: "stomach submucosa" EXACT [] synonym: "submucosa of ventriculus" EXACT [OBOL:automatic] synonym: "submucous layer of stomach" RELATED [BTO:0002110] synonym: "tela submucosa (gaster)" EXACT [] synonym: "tela submucosa gastricae" EXACT OMO:0003011 [FMA:14908, FMA:TA] synonym: "tela submucosa ventriculi" RELATED [BTO:0002110] synonym: "ventriculus submucosa" EXACT [OBOL:automatic] xref: BTO:0002110 xref: EMAPA:35825 xref: FMA:14908 xref: MA:0002685 xref: NCIT:C32663 xref: SCTID:52459002 xref: UMLS:C0227211 {source="ncithesaurus:Gastric_Submucosa"} is_a: UBERON:0018257 ! submucosa of digestive tract intersection_of: UBERON:0000009 ! submucosa intersection_of: BFO:0000050 UBERON:0000945 ! part of stomach relationship: BFO:0000050 UBERON:0001167 ! part of wall of stomach relationship: RO:0002433 UBERON:0001167 ! contributes to morphology of wall of stomach property_value: skos:prefLabel "submucosa of stomach" xsd:string [Term] id: UBERON:0001201 name: serosa of stomach def: "The outermost layer of the stomach wall, consisting of layers of connective tissue continuous with the peritoneum." [MGI:csmith, MP:0010793] subset: pheno_slim synonym: "anatomical wall of stomach serosa" EXACT [OBOL:automatic] synonym: "anatomical wall of stomach serous membrane" EXACT [OBOL:automatic] synonym: "anatomical wall of ventriculus serosa" EXACT [OBOL:automatic] synonym: "anatomical wall of ventriculus serous membrane" EXACT [OBOL:automatic] synonym: "gastric serosa" RELATED [] synonym: "gastric wall serosa" EXACT [OBOL:automatic] synonym: "gastric wall serous membrane" EXACT [OBOL:automatic] synonym: "serosa of anatomical wall of stomach" EXACT [OBOL:automatic] synonym: "serosa of anatomical wall of ventriculus" EXACT [OBOL:automatic] synonym: "serosa of gastric wall" EXACT [OBOL:automatic] synonym: "serosa of stomach anatomical wall" EXACT [OBOL:automatic] synonym: "serosa of stomach wall" EXACT [OBOL:automatic] synonym: "serosa of ventriculus anatomical wall" EXACT [OBOL:automatic] synonym: "serosa of ventriculus wall" EXACT [OBOL:automatic] synonym: "serosa of wall of stomach" EXACT [OBOL:automatic] synonym: "serosa of wall of ventriculus" EXACT [OBOL:automatic] synonym: "serous coat of stomach" EXACT [] synonym: "serous membrane of anatomical wall of stomach" EXACT [OBOL:automatic] synonym: "serous membrane of anatomical wall of ventriculus" EXACT [OBOL:automatic] synonym: "serous membrane of gastric wall" EXACT [OBOL:automatic] synonym: "serous membrane of stomach anatomical wall" EXACT [OBOL:automatic] synonym: "serous membrane of stomach wall" EXACT [OBOL:automatic] synonym: "serous membrane of ventriculus anatomical wall" EXACT [OBOL:automatic] synonym: "serous membrane of ventriculus wall" EXACT [OBOL:automatic] synonym: "serous membrane of wall of stomach" EXACT [OBOL:automatic] synonym: "serous membrane of wall of ventriculus" EXACT [OBOL:automatic] synonym: "stomach anatomical wall serosa" EXACT [OBOL:automatic] synonym: "stomach anatomical wall serous membrane" EXACT [OBOL:automatic] synonym: "stomach serosa" EXACT [] synonym: "stomach wall serosa" EXACT [OBOL:automatic] synonym: "stomach wall serous membrane" EXACT [OBOL:automatic] synonym: "tunica serosa (gaster)" EXACT [] synonym: "tunica serosa gastricae" EXACT OMO:0003011 [FMA:14914, FMA:TA] synonym: "ventriculus anatomical wall serosa" EXACT [OBOL:automatic] synonym: "ventriculus anatomical wall serous membrane" EXACT [OBOL:automatic] synonym: "ventriculus wall serosa" EXACT [OBOL:automatic] synonym: "ventriculus wall serous membrane" EXACT [OBOL:automatic] synonym: "visceral peritoneum of stomach" EXACT [] synonym: "wall of stomach serosa" EXACT [OBOL:automatic] synonym: "wall of stomach serous membrane" EXACT [OBOL:automatic] synonym: "wall of ventriculus serosa" EXACT [OBOL:automatic] synonym: "wall of ventriculus serous membrane" EXACT [OBOL:automatic] xref: EMAPA:35822 xref: FMA:14914 xref: MA:0001626 xref: NCIT:C32662 xref: SCTID:1353004 xref: UMLS:C1517453 {source="ncithesaurus:Gastric_Serosal_Surface"} is_a: UBERON:0004782 ! gastrointestinal system serosa intersection_of: UBERON:0000042 ! serous membrane intersection_of: BFO:0000050 UBERON:0001167 ! part of wall of stomach relationship: BFO:0000050 UBERON:0001167 ! part of wall of stomach relationship: RO:0002433 UBERON:0001167 ! contributes to morphology of wall of stomach property_value: IAO:0000116 "TODO - check serosa/peritoneum" xsd:string property_value: skos:prefLabel "serosa of stomach" xsd:string [Term] id: UBERON:0001202 name: pyloric sphincter def: "A strong ring of smooth muscle at the end of the pyloric canal which lets food pass from the stomach to the duodenum. It receives sympathetic innervation from the celiac ganglion[WP]." [https://orcid.org/0000-0002-6601-2165] subset: pheno_slim subset: uberon_slim synonym: "pyloric valve" EXACT [Wikipedia:Pylorus] xref: AAO:0011093 xref: EMAPA:19251 xref: FMA:14916 xref: MA:0002952 xref: NCIT:C33433 xref: SCTID:268073008 xref: UMLS:C0227238 {source="ncithesaurus:Pyloric_Sphincter"} xref: VHOG:0001466 xref: XAO:0000457 is_a: UBERON:0011185 ! gastrointestinal sphincter intersection_of: UBERON:0004590 ! sphincter muscle intersection_of: BFO:0000050 UBERON:0001166 ! part of pylorus relationship: BFO:0000050 UBERON:0001166 ! part of pylorus relationship: RO:0002150 UBERON:0008858 ! continuous with pyloric canal relationship: RO:0002220 UBERON:0002114 ! adjacent to duodenum relationship: RO:0002433 UBERON:0001166 ! contributes to morphology of pylorus property_value: RO:0002161 NCBITaxon:8355 property_value: skos:prefLabel "pyloric sphincter" xsd:string [Term] id: UBERON:0001203 name: muscularis mucosae of stomach def: "The thin layer of smooth muscle in the mucosal layer of the stomach that functions to agitate the surface area stomach mucosa by moving the villi back and forth." [MGI:csmith, MP:0010806] subset: pheno_slim synonym: "gastric muscularis mucosa" EXACT [] synonym: "lamina muscularis mucosae (tunica mucosa)(gaster)" EXACT [] synonym: "lamina muscularis mucosae gastricae" EXACT OMO:0003011 [FMA:14924, FMA:TA] synonym: "lamina muscularis of gastric mucosa" EXACT [] synonym: "muscular coat of stomach" EXACT [] synonym: "stomach muscularis mucosa" EXACT [] synonym: "tunica muscularis gastricae" EXACT OMO:0003011 [FMA:14924, FMA:TA] xref: EMAPA:35818 xref: FMA:14924 xref: MA:0002684 xref: NCIT:C32658 xref: SCTID:64551004 xref: UMLS:C0227200 {source="ncithesaurus:Gastric_Muscularis_Mucosa"} is_a: UBERON:0004222 ! stomach smooth muscle is_a: UBERON:0006676 ! muscularis mucosa intersection_of: UBERON:0006676 ! muscularis mucosa intersection_of: BFO:0000050 UBERON:0001199 ! part of mucosa of stomach relationship: BFO:0000050 UBERON:0001199 ! part of mucosa of stomach relationship: RO:0002433 UBERON:0001199 ! contributes to morphology of mucosa of stomach [Term] id: UBERON:0001204 name: mucosa of small intestine def: "A mucosa that is part of a small intestine [Automatically generated definition]." [OBOL:automatic] synonym: "mucosa of organ of small bowel" EXACT [OBOL:automatic] synonym: "mucosa of organ of small intestine" EXACT [OBOL:automatic] synonym: "mucosa of small bowel" EXACT [OBOL:automatic] synonym: "mucous membrane of small bowel" EXACT [OBOL:automatic] synonym: "mucous membrane of small intestine" EXACT [] synonym: "organ mucosa of small bowel" EXACT [OBOL:automatic] synonym: "organ mucosa of small intestine" EXACT [OBOL:automatic] synonym: "small bowel mucosa" EXACT [OBOL:automatic] synonym: "small bowel mucosa of organ" EXACT [OBOL:automatic] synonym: "small bowel mucous membrane" EXACT [OBOL:automatic] synonym: "small bowel organ mucosa" EXACT [OBOL:automatic] synonym: "small intestinal mucosa" EXACT [] synonym: "small intestine mucosa" EXACT [] synonym: "small intestine mucosa of organ" EXACT [OBOL:automatic] synonym: "small intestine mucous membrane" EXACT [] synonym: "small intestine organ mucosa" EXACT [OBOL:automatic] synonym: "tunica mucosa (intestinum tenue)" EXACT [] synonym: "tunica mucosa intestini tenuis" EXACT OMO:0003011 [FMA:14933, FMA:TA] xref: BTO:0001259 xref: CALOHA:TS-0941 xref: EMAPA:35780 xref: FMA:14933 xref: MA:0002686 xref: NCIT:C33568 xref: SCTID:362144000 xref: UMLS:C0227261 {source="ncithesaurus:Small_Intestinal_Mucosa"} is_a: UBERON:0001242 ! intestinal mucosa intersection_of: UBERON:0000344 ! mucosa intersection_of: BFO:0000050 UBERON:0002108 ! part of small intestine relationship: BFO:0000050 UBERON:0001168 ! part of wall of small intestine relationship: BFO:0000050 UBERON:0001242 ! part of intestinal mucosa property_value: skos:prefLabel "mucosa of small intestine" xsd:string [Term] id: UBERON:0001205 name: submucosa of small intestine def: "Submucosal tissue in the small intestines." [Wikipedia:Small_intestinal_submucosa] subset: uberon_slim synonym: "small bowel submucosa" EXACT [OBOL:automatic] synonym: "small intestinal submucosa" EXACT [] synonym: "small intestine submucosa" EXACT [] synonym: "submucosa of small bowel" EXACT [OBOL:automatic] synonym: "tela submucosa (intestinum tenue)" EXACT [] synonym: "tela submucosa intestini tenuis" EXACT OMO:0003011 [BTO:0002112] xref: BTO:0002112 xref: EMAPA:37564 {source="MA:th"} xref: FMA:14934 xref: MA:0001562 xref: NCIT:C33572 xref: SCTID:691000 xref: UMLS:C0227268 {source="ncithesaurus:Small_Intestinal_Submucosa"} xref: Wikipedia:Small_intestinal_submucosa is_a: UBERON:0009566 ! intestinal submucosa intersection_of: UBERON:0000009 ! submucosa intersection_of: BFO:0000050 UBERON:0002108 ! part of small intestine relationship: BFO:0000050 UBERON:0001168 ! part of wall of small intestine property_value: skos:prefLabel "submucosa of small intestine" xsd:string [Term] id: UBERON:0001206 name: serosa of small intestine def: "A serous membrane that is part of a small intestine [Automatically generated definition]." [OBOL:automatic] synonym: "serosa of small bowel" EXACT [OBOL:automatic] synonym: "serous coat of small intestine" EXACT [] synonym: "serous membrane of small bowel" EXACT [OBOL:automatic] synonym: "serous membrane of small intestine" EXACT [OBOL:automatic] synonym: "small bowel serosa" EXACT [OBOL:automatic] synonym: "small bowel serous membrane" EXACT [OBOL:automatic] synonym: "small intestinal serosa" EXACT [] synonym: "small intestine serosa" EXACT [] synonym: "small intestine serous membrane" EXACT [OBOL:automatic] synonym: "tunica serosa (intestinum tenue)" EXACT [] synonym: "tunica serosa intestini tenuis" EXACT OMO:0003011 [FMA:14938, FMA:TA] synonym: "visceral peritoneum of small intestine" EXACT [] xref: EMAPA:37561 {source="MA:th"} xref: FMA:14938 xref: MA:0001558 xref: SCTID:8266009 is_a: UBERON:0001243 ! serosa of intestine intersection_of: UBERON:0000042 ! serous membrane intersection_of: BFO:0000050 UBERON:0002108 ! part of small intestine relationship: BFO:0000050 UBERON:0001168 ! part of wall of small intestine relationship: BFO:0000050 UBERON:0001243 ! part of serosa of intestine property_value: skos:prefLabel "serosa of small intestine" xsd:string [Term] id: UBERON:0001207 name: mucosa of large intestine def: "A mucosa that is part of a large intestine [Automatically generated definition]." [OBOL:automatic] synonym: "large intestinal mucosa" EXACT [] synonym: "large intestine mucosa" EXACT [] synonym: "large intestine mucosa of organ" EXACT [OBOL:automatic] synonym: "large intestine mucous membrane" EXACT [OBOL:automatic] synonym: "large intestine organ mucosa" EXACT [OBOL:automatic] synonym: "mucosa of organ of large intestine" EXACT [OBOL:automatic] synonym: "mucous membrane of large intestine" EXACT [] synonym: "organ mucosa of large intestine" EXACT [OBOL:automatic] synonym: "tunica mucosa intestini crassi" EXACT OMO:0003011 [FMA:14969, FMA:TA] xref: CALOHA:TS-2106 xref: EMAPA:35467 xref: FMA:14969 xref: MA:0002688 xref: NCIT:C32926 xref: UMLS:C0734203 {source="ncithesaurus:Large_Intestinal_Mucosa"} is_a: UBERON:0001242 ! intestinal mucosa intersection_of: UBERON:0000344 ! mucosa intersection_of: BFO:0000050 UBERON:0000059 ! part of large intestine relationship: BFO:0000050 UBERON:0001169 ! part of wall of large intestine relationship: BFO:0000050 UBERON:0001242 ! part of intestinal mucosa property_value: skos:prefLabel "mucosa of large intestine" xsd:string [Term] id: UBERON:0001208 name: submucosa of large intestine def: "A submucosa that is part of a large intestine [Automatically generated definition]." [OBOL:automatic] synonym: "large intestinal submucosa" EXACT [] synonym: "large intestine submucosa" EXACT [] synonym: "submucous layer of large intestine" RELATED [BTO:0002111] synonym: "tela submucosa intestini crassi" EXACT OMO:0003011 [FMA:14970, FMA:TA] xref: BTO:0002111 xref: EMAPA:37560 {source="MA:th"} xref: FMA:14970 xref: MA:0002690 xref: NCIT:C32930 xref: UMLS:C0734204 {source="ncithesaurus:Large_Intestinal_Submucosa"} is_a: UBERON:0009566 ! intestinal submucosa intersection_of: UBERON:0000009 ! submucosa intersection_of: BFO:0000050 UBERON:0000059 ! part of large intestine relationship: BFO:0000050 UBERON:0001169 ! part of wall of large intestine property_value: skos:prefLabel "submucosa of large intestine" xsd:string [Term] id: UBERON:0001209 name: serosa of large intestine def: "A serous membrane that is part of a large intestine [Automatically generated definition]." [OBOL:automatic] synonym: "large intestinal serosa" EXACT [] synonym: "large intestine serosa" EXACT [] synonym: "large intestine serous membrane" EXACT [OBOL:automatic] synonym: "serous coat of large intestine" EXACT [] synonym: "serous membrane of large intestine" EXACT [OBOL:automatic] synonym: "tunica serosa intestini crassi" EXACT OMO:0003011 [FMA:14975, FMA:TA] synonym: "visceral peritoneum of large intestine" EXACT [] xref: EMAPA:37557 {source="MA:th"} xref: FMA:14975 xref: MA:0001546 xref: NCIT:C32929 xref: UMLS:C1517727 {source="ncithesaurus:Large_Intestinal_Serosal_Surface"} is_a: UBERON:0001243 ! serosa of intestine intersection_of: UBERON:0000042 ! serous membrane intersection_of: BFO:0000050 UBERON:0000059 ! part of large intestine relationship: BFO:0000050 UBERON:0001169 ! part of wall of large intestine relationship: BFO:0000050 UBERON:0001243 ! part of serosa of intestine property_value: IAO:0000116 "TODO - check serosa/peritoneum" xsd:string property_value: skos:prefLabel "serosa of large intestine" xsd:string [Term] id: UBERON:0001210 name: muscularis mucosae of small intestine def: "A muscularis mucosa that is part of a small intestine." [OBOL:automatic] synonym: "lamina muscularis mucosae (tunica mucosa)(intestinum tenue)" EXACT [] synonym: "lamina muscularis mucosae intestini tenuis" EXACT OMO:0003011 [FMA:15051, FMA:TA] synonym: "lamina muscularis of small intestine mucous membrane" EXACT [] synonym: "small intestine muscularis mucosa" EXACT [] xref: EMAPA:35781 xref: FMA:15051 xref: MA:0002687 xref: NCIT:C33570 xref: SCTID:36401004 xref: UMLS:C0227262 {source="ncithesaurus:Small_Intestinal_Muscularis_Mucosa"} is_a: UBERON:0001240 ! muscularis mucosae of intestine is_a: UBERON:0004239 ! small intestine smooth muscle intersection_of: UBERON:0006676 ! muscularis mucosa intersection_of: BFO:0000050 UBERON:0002108 ! part of small intestine relationship: BFO:0000050 UBERON:0001204 ! part of mucosa of small intestine relationship: BFO:0000050 UBERON:0001240 ! part of muscularis mucosae of intestine [Term] id: UBERON:0001211 name: Peyer's patch def: "The protruding lymphoid tissue located on the mucosa of the intestine that is composed of densely packed B cell follicles." [http://orcid.org/0000-0002-6601-2165, MESH:A10.549.600, MP:0000696, PMID:15841100] subset: efo_slim subset: pheno_slim subset: uberon_slim synonym: "aggregated lymphoid follicle of intestine" RELATED [] synonym: "aggregated lymphoid nodule" RELATED [] synonym: "noduli lymphoidei aggregati" EXACT OMO:0003011 [] synonym: "Peyers gland" RELATED [BTO:0001784] synonym: "Peyers patch" RELATED [BTO:0001784] xref: BTO:0001784 xref: CALOHA:TS-0780 xref: EFO:0001381 xref: EMAPA:19028 xref: GAID:950 xref: MA:0000137 xref: MESH:D010581 xref: NCIT:C12771 xref: UMLS:C0031272 {source="ncithesaurus:Peyer_s_Patch"} xref: Wikipedia:Peyer's_patch is_a: UBERON:0001962 {source="FMA", source="MA"} ! gut-associated lymphoid tissue relationship: BFO:0000050 UBERON:0000030 {comment="EDITOR_NOTE check this"} ! part of lamina propria relationship: BFO:0000050 UBERON:0001242 ! part of intestinal mucosa relationship: RO:0002162 NCBITaxon:32524 {source="PMID:PMID:20181529"} ! in taxon Amniota property_value: RO:0002161 NCBITaxon:8459 {source="PMID:PMID:20181529"} [Term] id: UBERON:0001212 name: duodenal gland def: "A compound tubular submucosal gland found in that portion of the duodenum which is above the hepatopancreatic sphincter (Sphincter of Oddi). The main function of these glands is to produce a mucus-rich alkaline secretion (containing bicarbonate)[WP]." [Wikipedia:Brunner's_glands] subset: organ_slim subset: pheno_slim subset: uberon_slim synonym: "Brunner's gland" EXACT [FMA:15060] synonym: "gland of Brunner" EXACT [FMA:15060] synonym: "glandula duodenales" RELATED OMO:0003011 [BTO:0002376] synonym: "glandula duodenales Brunneri" RELATED OMO:0003011 [BTO:0002376] synonym: "submucosal gland of duodenum" EXACT [] xref: BTO:0002376 xref: EMAPA:36522 xref: FMA:15060 xref: GAID:314 xref: MA:0001551 xref: MESH:D002011 xref: NCIT:C13010 xref: SCTID:41298001 xref: UMLS:C0006323 {source="ncithesaurus:Brunner_s_Gland"} xref: Wikipedia:Brunner's_glands is_a: UBERON:0003408 ! gland of digestive tract is_a: UBERON:0011148 ! submucosal gland intersection_of: UBERON:0011148 ! submucosal gland intersection_of: BFO:0000050 UBERON:0002114 ! part of duodenum relationship: BFO:0000050 UBERON:0002114 ! part of duodenum relationship: RO:0001025 UBERON:0003332 {source="FMA, modified"} ! located in submucosa of duodenum relationship: RO:0002162 NCBITaxon:40674 ! in taxon Mammalia property_value: IAO:0000116 "currently defined as equivalent to any submucosal gland in the duodenum." xsd:string property_value: skos:prefLabel "duodenal gland" xsd:string [Term] id: UBERON:0001213 name: intestinal villus def: "The tiny hair-like projections that protrude from the inside of the small intestine that contain blood vessels that capture digested nutrients that are absorbed through the intestinal wall; the villi increase the absorptive surface area of the small intestine by approximately 30-fold." [MGI:csmith, MGI:rbabiuk, MP:0008108] subset: human_reference_atlas subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "enteric villi" EXACT OMO:0003004 [HP:0011473] synonym: "enteric villous" EXACT [HP:0011473] synonym: "enteric villus" EXACT [HP:0011473] synonym: "intestinal villi" EXACT OMO:0003004 [ZFA:0005125] synonym: "intestinal villus layer" RELATED [] synonym: "small intestine villus" RELATED [MA:0001563] synonym: "villi intestinales" EXACT OMO:0003004 [] synonym: "villi intestinales" RELATED OMO:0003011 [Wikipedia:Intestinal_villus] synonym: "villus" EXACT [BTO:0003121] synonym: "villus intestinalis (intestinum tenue)" EXACT [FMA:15072] xref: BTO:0003121 xref: EMAPA:35784 xref: FMA:15072 xref: MA:0001563 xref: NCIT:C33874 xref: SCTID:23230007 xref: TAO:0005125 xref: UMLS:C1519988 {source="ncithesaurus:Villus"} xref: Wikipedia:Intestinal_villus xref: ZFA:0005125 is_a: BFO:0000002 is_a: UBERON:0004923 {source="FMA"} ! organ component layer relationship: BFO:0000050 UBERON:0001277 {source="ZFA"} ! part of intestinal epithelium relationship: BFO:0000051 UBERON:0001981 ! has part blood vessel relationship: BFO:0000051 UBERON:0012425 ! has part striated border microvillus layer property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/3/38/Small_intestine_low_mag.jpg" xsd:anyURI property_value: IAO:0000116 "in mammals, villi are (largely?) absent from the large intestine, so we treat this as equivalent to small intestinal villus. small/large subdivision may not make sense for all species for which this is present (see ZFA). Note that VHOG quotes ISBN:978-0030223693 as suggesting there are some villi in the large intestine" xsd:string property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "intestinal villus" xsd:string [Term] id: UBERON:0001215 name: inferior mesenteric vein def: "A blood vessel that drains blood from the large intestine that usually terminates when reaching the splenic vein, which goes on to form the portal vein with the superior mesenteric vein (SMV). Anatomical variations include the IMV draining into the confluence of the SMV and splenic vein and the IMV draining in the SMV. The IMV lies to the right of the similarly name artery, the inferior mesenteric artery, which originates from the abdominal aorta. [WP,unvetted]." [Wikipedia:Inferior_mesenteric_vein] subset: human_reference_atlas subset: uberon_slim synonym: "lower mesenteric vein" RELATED [BTO:0002782] synonym: "vena mesenterica inferior" RELATED OMO:0003011 [Wikipedia:Inferior_mesenteric_vein] xref: BTO:0002782 xref: EHDAA2:0000819 xref: EHDAA:8712 xref: EMAPA:18642 xref: FMA:15391 xref: MA:0002178 xref: NCIT:C32782 xref: SCTID:281055007 xref: UMLS:C0226754 {source="ncithesaurus:Inferior_Mesenteric_Vein"} xref: VHOG:0001118 xref: Wikipedia:Inferior_mesenteric_vein is_a: UBERON:0005617 ! mesenteric vein intersection_of: UBERON:0005617 ! mesenteric vein intersection_of: RO:0020102 UBERON:0000059 ! vessel drains blood from large intestine relationship: RO:0002376 UBERON:0003713 {source="FMA/obol"} ! tributary of splenic vein relationship: RO:0020102 UBERON:0000059 ! vessel drains blood from large intestine property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/3/33/Gray591.png" xsd:anyURI property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/blood-vasculature-male/v1.3/assets/3d-vh-m-blood-vasculature.glb" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "inferior mesenteric vein" xsd:string [Term] id: UBERON:0001216 name: jejunal vein def: "A tributary of the superior mesenteric vein that drains the jejunum." [http://orcid.org/0000-0002-6601-2165, Wikipedia:Jejunal_veins] subset: human_reference_atlas synonym: "venae jejunales" RELATED OMO:0003011 [Wikipedia:Jejunal_veins] xref: EMAPA:37160 {source="MA:th"} xref: FMA:15402 xref: MA:0002153 xref: Wikipedia:Jejunal_veins is_a: UBERON:0002017 {source="FMA"} ! portal vein intersection_of: UBERON:0001638 ! vein intersection_of: RO:0020102 UBERON:0002115 ! vessel drains blood from jejunum relationship: RO:0002376 UBERON:0001138 {source="FMA/obol"} ! tributary of superior mesenteric vein relationship: RO:0020102 UBERON:0002115 ! vessel drains blood from jejunum property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/3/33/Gray591.png" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001217 name: ileal vein def: "The veins that drain blood from the ileum into the superior mesenteric vein." [ncithesaurus:Ileal_Vein] subset: human_reference_atlas xref: EMAPA:37149 {source="MA:th"} xref: FMA:15405 xref: MA:0002140 xref: NCIT:C53046 xref: UMLS:C1301431 {source="ncithesaurus:Ileal_Vein"} xref: Wikipedia:Ileal_veins is_a: UBERON:0002017 ! portal vein intersection_of: UBERON:0001638 ! vein intersection_of: RO:0020102 UBERON:0002116 ! vessel drains blood from ileum relationship: BFO:0000050 UBERON:0001138 ! part of superior mesenteric vein relationship: RO:0002376 UBERON:0001138 {source="FMA", source="Wikipedia"} ! tributary of superior mesenteric vein relationship: RO:0020102 UBERON:0002116 ! vessel drains blood from ileum property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001218 name: middle colic vein def: "The middle colic vein drains the transverse colon. It is a tributary of the superior mesenteric vein, and follows the path of its corresponding artery, the middle colic artery. [WP,unvetted]." [Wikipedia:Middle_colic_vein] subset: human_reference_atlas subset: uberon_slim synonym: "vena colica media" RELATED OMO:0003011 [Wikipedia:Middle_colic_vein] synonym: "vena colica media (intermedia)" EXACT [] xref: EMAPA:37174 {source="MA:th"} xref: FMA:15406 xref: MA:0002181 xref: SCTID:9018004 xref: Wikipedia:Middle_colic_vein is_a: UBERON:0002017 ! portal vein intersection_of: UBERON:0002017 ! portal vein intersection_of: RO:0002376 UBERON:0001138 ! tributary of superior mesenteric vein intersection_of: RO:0020102 UBERON:0001157 ! vessel drains blood from transverse colon relationship: RO:0002376 UBERON:0001138 ! tributary of superior mesenteric vein relationship: RO:0020102 UBERON:0001157 ! vessel drains blood from transverse colon property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/3/33/Gray591.png" xsd:anyURI property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/blood-vasculature-female/v1.3/assets/3d-vh-f-blood-vasculature.glb" xsd:anyURI property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/blood-vasculature-male/v1.3/assets/3d-vh-m-blood-vasculature.glb" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001219 name: ileocolic vein def: "The ileocolic vein is a vein which drains the ileum, colon, and cecum. [WP,unvetted]." [Wikipedia:Ileocolic_vein] subset: human_reference_atlas subset: uberon_slim synonym: "vena ileocolica" RELATED OMO:0003011 [Wikipedia:Ileocolic_vein] xref: EMAPA:37150 {source="MA:th"} xref: FMA:15408 xref: MA:0002141 xref: NCIT:C53047 xref: SCTID:36208008 xref: UMLS:C0226744 {source="ncithesaurus:Ileocolic_Vein"} xref: Wikipedia:Ileocolic_vein is_a: UBERON:0001217 ! ileal vein intersection_of: UBERON:0002017 ! portal vein intersection_of: RO:0002376 UBERON:0001138 ! tributary of superior mesenteric vein intersection_of: RO:0020102 UBERON:0001153 ! vessel drains blood from caecum intersection_of: RO:0020102 UBERON:0001155 ! vessel drains blood from colon intersection_of: RO:0020102 UBERON:0002116 ! vessel drains blood from ileum relationship: RO:0020102 UBERON:0001153 ! vessel drains blood from caecum relationship: RO:0020102 UBERON:0001155 ! vessel drains blood from colon property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/3/33/Gray591.png" xsd:anyURI property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/blood-vasculature-female/v1.3/assets/3d-vh-f-blood-vasculature.glb" xsd:anyURI property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/blood-vasculature-male/v1.3/assets/3d-vh-m-blood-vasculature.glb" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001222 name: right ureter def: "An ureter that is part of a right side of organism [Automatically generated definition]." [OBOL:automatic] xref: EMAPA:37373 {source="MA:th"} xref: FMA:15571 xref: MA:0001685 xref: NCIT:C49327 xref: SCTID:276251000 xref: UMLS:C0227682 {source="ncithesaurus:Right_Ureter"} is_a: UBERON:0000056 ! ureter intersection_of: UBERON:0000056 ! ureter intersection_of: BSPO:0000121 UBERON:0000468 ! multicellular organism relationship: BSPO:0000121 UBERON:0000468 ! multicellular organism property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/ureter-female-right/v1.2/assets/3d-vh-f-ureter-r.glb" xsd:anyURI property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/ureter-male-right/v1.2/assets/3d-vh-m-ureter-r.glb" xsd:anyURI [Term] id: UBERON:0001223 name: left ureter def: "An ureter that is part of a left side of organism [Automatically generated definition]." [OBOL:automatic] xref: EMAPA:37372 {source="MA:th"} xref: FMA:15572 xref: MA:0001684 xref: NCIT:C49324 xref: SCTID:276340002 xref: UMLS:C0227683 {source="ncithesaurus:Left_Ureter"} is_a: UBERON:0000056 ! ureter intersection_of: UBERON:0000056 ! ureter intersection_of: BSPO:0000120 UBERON:0000468 ! multicellular organism relationship: BSPO:0000120 UBERON:0000468 ! multicellular organism property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/ureter-female-left/v1.2/assets/3d-vh-f-ureter-l.glb" xsd:anyURI property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/ureter-male-left/v1.2/assets/3d-vh-m-ureter-l.glb" xsd:anyURI [Term] id: UBERON:0001224 name: renal pelvis def: "A funnel shaped proximal portion of the ureter that is formed by convergence of the major calices [MP]." [MP:0004194] comment: In this ontology, the renal pelvis is represented as the area of part-overlap between the kidney and the ureter subset: human_reference_atlas subset: pheno_slim subset: uberon_slim synonym: "kidney pelvis" EXACT [] synonym: "p. renallis" RELATED OMO:0003011 [Wikipedia:Renal_pelvis] synonym: "pelvis of ureter" EXACT [] synonym: "pyelum" RELATED [MP:0004194] xref: CALOHA:TS-2230 xref: EMAPA:17948 xref: FMA:15575 xref: GAID:426 xref: galen:RenalPelvis xref: MA:0000374 xref: MESH:D007682 xref: NCIT:C12887 xref: SCTID:362221007 xref: UMLS:C0227666 {source="ncithesaurus:Renal_Pelvis"} xref: Wikipedia:Renal_pelvis is_a: UBERON:0000064 ! organ part is_a: UBERON:0004111 ! anatomical conduit disjoint_from: UBERON:0002355 ! pelvic region of trunk relationship: BFO:0000050 UBERON:0002113 {source="MA"} ! part of kidney relationship: BFO:0000050 UBERON:0036295 ! part of renal pelvis/ureter relationship: channel_for UBERON:0001088 ! urine relationship: channels_from UBERON:0002113 ! kidney relationship: channels_into UBERON:0000056 ! ureter relationship: RO:0002150 UBERON:0000056 {source="FMA"} ! continuous with ureter relationship: RO:0002433 UBERON:0000056 ! contributes to morphology of ureter property_value: foaf:depiction "https://upload.wikimedia.org/wikipedia/commons/c/c0/Illu_kidney2.jpg" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001225 name: cortex of kidney def: "Outer cortical portion of the kidney, between the renal capsule and the renal medulla." [Wikipedia:Renal_cortex] subset: human_reference_atlas subset: pheno_slim subset: uberon_slim synonym: "cortex renalis" EXACT OMO:0003011 [FMA:15581, FMA:TA] synonym: "kidney cortex" EXACT [] synonym: "renal cortex" EXACT [] xref: BTO:0001166 xref: CALOHA:TS-0503 xref: EMAPA:17952 xref: FMA:15581 xref: GAID:424 xref: galen:CortexOfKidney xref: MA:0000372 xref: MESH:D007672 xref: NCIT:C12739 xref: SCTID:362211004 xref: UMLS:C0022655 {source="ncithesaurus:Renal_Cortex"} xref: Wikipedia:Renal_cortex is_a: UBERON:0001851 ! cortex intersection_of: UBERON:0001851 ! cortex intersection_of: BFO:0000050 UBERON:0002113 ! part of kidney relationship: BFO:0000050 UBERON:0008987 {source="FMA"} ! part of renal parenchyma relationship: RO:0002433 UBERON:0002113 ! contributes to morphology of kidney property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/kidney-female-left/v1.3/assets/3d-vh-f-kidney-l.glb" xsd:anyURI property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/kidney-female-right/v1.3/assets/3d-vh-f-kidney-r.glb" xsd:anyURI property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/kidney-male-left/v1.3/assets/3d-vh-m-kidney-l.glb" xsd:anyURI property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/kidney-male-right/v1.3/assets/3d-vh-m-kidney-r.glb" xsd:anyURI property_value: foaf:depiction "https://upload.wikimedia.org/wikipedia/commons/6/69/Illu_kidney.jpg" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001228 name: renal papilla def: "Tip of renal pyramid projecting into a minor calyx." [http://anatomy.uams.edu/anatomyhtml/kidney.html] subset: human_reference_atlas subset: pheno_slim subset: uberon_slim synonym: "kidney papilla" EXACT [MP:0011303] xref: BTO:0003925 xref: EMAPA:35727 xref: FMA:15622 xref: galen:RenalPapilla xref: MA:0002730 xref: MESH:D007679 xref: NCIT:C33460 xref: SCTID:362214007 xref: UMLS:C0022666 {source="ncithesaurus:Renal_Papilla"} xref: Wikipedia:Renal_papilla is_a: UBERON:0000064 ! organ part relationship: BFO:0000050 UBERON:0001224 ! part of renal pelvis relationship: BFO:0000050 UBERON:0001294 ! part of inner medulla of kidney relationship: RO:0002433 UBERON:0001224 ! contributes to morphology of renal pelvis property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/kidney-female-left/v1.3/assets/3d-vh-f-kidney-l.glb" xsd:anyURI property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/kidney-female-right/v1.3/assets/3d-vh-f-kidney-r.glb" xsd:anyURI property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/kidney-male-left/v1.3/assets/3d-vh-m-kidney-l.glb" xsd:anyURI property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/kidney-male-right/v1.3/assets/3d-vh-m-kidney-r.glb" xsd:anyURI property_value: foaf:depiction "https://upload.wikimedia.org/wikipedia/commons/7/7e/Kidney_PioM.png" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001229 name: renal corpuscle def: "The structure containing the glomerular capsule and the glomerulus that serves as the initial blood-filtering component of a nephron." [ISBN:0-683-40008-8, MP:0002827] comment: Together, the Bowmans capsule and the glomerulus comprise the definitive renal corpuscle. http://www.gudmap.org/About/Tutorial/DevMUS.html#DMK_Nephron subset: human_reference_atlas subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "corpusculum renale" EXACT OMO:0003011 [] synonym: "corpusculum renis" RELATED OMO:0003011 [Wikipedia:Renal_corpuscle] synonym: "cortical renal corpuscle" RELATED [MA:0000376] synonym: "kidney corpuscle" RELATED [Wikipedia:Renal_corpuscle] synonym: "Malphigian corpuscle" EXACT MISSPELLING [MA:0000376] synonym: "Malpighian corpuscle" EXACT [ZFA:0005281] xref: BTO:0000333 xref: CALOHA:TS-1317 xref: EMAPA:28236 xref: EMAPA:35726 xref: EV:0100385 xref: FMA:15625 xref: MA:0000376 xref: NCIT:C33456 xref: SCTID:361329009 xref: TAO:0005281 xref: UMLS:C0227635 {source="ncithesaurus:Renal_Corpuscle"} xref: VHOG:0001262 xref: Wikipedia:Renal_corpuscle xref: ZFA:0005281 is_a: UBERON:0000063 ! organ subunit relationship: BFO:0000050 UBERON:0001225 ! part of cortex of kidney relationship: BFO:0000050 UBERON:0001285 {source="MA", source="ZFA"} ! part of nephron relationship: RO:0002433 UBERON:0001225 ! contributes to morphology of cortex of kidney relationship: RO:0002433 UBERON:0001285 ! contributes to morphology of nephron property_value: foaf:depiction "https://upload.wikimedia.org/wikipedia/commons/2/22/Renal_corpuscle.svg" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001230 name: glomerular capsule def: "A cup-like sac at the expanded beginning of a tubular component of a nephron that contains the glomerulus." [MGI:pvb, MP:0002828, Wikipedia:Bowman%27s_capsule] subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "Bowman's capsule" EXACT [http://www.gudmap.org/About/Tutorial/DevMUS.html#DMK_Nephron] synonym: "Bowman's capsule" RELATED [TAO:0005254] synonym: "Bowmans capsule" EXACT [KUPO:0001001] synonym: "capsula glomerularis" EXACT OMO:0003011 [] synonym: "capsula glomeruli" RELATED OMO:0003011 [] synonym: "Malphigian capsule" RELATED MISSPELLING [BTO:0002297] synonym: "Malpighian capsule" RELATED [UBERON:cjm] synonym: "Mueller capsule" RELATED [BTO:0002297] synonym: "Muellerian capsule" RELATED [BTO:0002297] synonym: "pronephric glomerular capsule" RELATED [TAO:0005310] synonym: "renal glomerular capsule" EXACT [TAO:0005254] xref: AAO:0010526 xref: BTO:0002297 xref: EMAPA:27973 xref: EMAPA:28257 xref: FMA:15626 xref: KUPO:0001001 xref: MA:0001660 xref: NCIT:C32225 xref: SCTID:361331000 xref: TAO:0005254 xref: TAO:0005310 xref: UMLS:C0524448 {source="ncithesaurus:Bowman_s_Capsule"} xref: Wikipedia:Bowman%27s_capsule xref: ZFA:0005254 xref: ZFA:0005310 is_a: BFO:0000002 is_a: UBERON:0000064 ! organ part disjoint_from: UBERON:0002015 ! kidney capsule relationship: BFO:0000050 UBERON:0001229 ! part of renal corpuscle relationship: RO:0002202 UBERON:0004199 ! develops from S-shaped body relationship: RO:0002216 GO:0003094 {source="Wikipedia"} ! capable of part of glomerular filtration relationship: RO:0002433 UBERON:0001229 ! contributes to morphology of renal corpuscle property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/3/30/Gray1130.svg" xsd:anyURI [Term] id: UBERON:0001231 name: nephron tubule def: "An epithelial tube that is part of the nephron, the functional part of the kidney." [GO:0072078, Wikipedia:Renal_tubule] subset: efo_slim subset: human_reference_atlas subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "kidney tubule" EXACT [GAID:433] synonym: "renal tubule" BROAD [] synonym: "tubulus renalis" EXACT [] synonym: "uriniferous tubule" RELATED [MA:0000377] xref: BTO:0000343 xref: CALOHA:TS-1262 xref: EFO:0003666 xref: EMAPA:27782 xref: EV:0100387 xref: FMA:15627 xref: GAID:433 xref: MA:0000377 xref: MESH:D007684 xref: NCIT:C49274 xref: SCTID:361332007 xref: TAO:0001287 xref: UMLS:C0022674 {source="ncithesaurus:Renal_Tubule"} xref: Wikipedia:Renal_tubule xref: ZFA:0001287 is_a: BFO:0000002 is_a: UBERON:0004211 ! nephron epithelium is_a: UBERON:0009773 {source="GO"} ! renal tubule intersection_of: UBERON:0003914 {source="GO", source="MA", source="ZFA"} ! epithelial tube intersection_of: BFO:0000050 UBERON:0001285 {source="GO", source="MA", source="ZFA"} ! part of nephron relationship: BFO:0000051 CL:0005009 {source="ZFA"} ! has part renal principal cell relationship: RO:0002202 UBERON:0003918 ! develops from kidney mesenchyme relationship: RO:0002433 UBERON:0001285 ! contributes to morphology of nephron property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001232 name: collecting duct of renal tubule def: "The collecting duct is a portion of the nephron through which water flows, moving passively down its concentration gradient." [GO:0072044, Wikipedia:Collecting_tubule] subset: human_reference_atlas subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "arcuate renal tubule" RELATED [Wikipedia:Connecting_tubule] synonym: "collecting duct" EXACT [GO:0072044] synonym: "collecting duct system" RELATED [BTO:0000761] synonym: "collecting tubule" RELATED [] synonym: "junctional tube" RELATED [Wikipedia:Connecting_tubule] synonym: "kidney collecting duct" EXACT [] synonym: "kidney collecting tubule" RELATED [] synonym: "renal collecting tubule" EXACT [FMA:15628] synonym: "tubulus renalis arcuatus" EXACT OMO:0003011 [Wikipedia:Connecting_tubule] synonym: "tubulus renalis colligens" EXACT [] synonym: "ureteric tree" RELATED [EMAPA:28407] xref: BTO:0000761 xref: CALOHA:TS-0860 xref: EMAPA:28407 xref: EV:0100391 xref: FMA:15628 xref: GAID:434 xref: MA:0000371 xref: MESH:D007685 xref: SCTID:28202009 xref: TAO:0005294 xref: Wikipedia:Collecting_tubule xref: ZFA:0005294 is_a: UBERON:0006555 ! excretory tube relationship: BFO:0000050 UBERON:0001285 ! part of nephron relationship: BFO:0000050 UBERON:0004100 ! part of renal collecting system relationship: RO:0002433 UBERON:0002113 ! contributes to morphology of kidney property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001233 name: right adrenal gland def: "An adrenal gland that is in the right side of the abdomen." [OBOL:automatic] synonym: "glandula suprarenalis dexter" EXACT OMO:0003011 [] synonym: "right suprarenal gland" EXACT [] xref: EMAPA:37357 {source="MA:th"} xref: FMA:15629 xref: MA:0000719 xref: NCIT:C49325 xref: SCTID:281625001 xref: UMLS:C0229559 {source="ncithesaurus:Right_Adrenal_Gland"} is_a: UBERON:0002369 ! adrenal gland intersection_of: UBERON:0002369 ! adrenal gland intersection_of: BSPO:0000121 UBERON:0000916 ! abdomen relationship: BSPO:0000121 UBERON:0000916 ! abdomen [Term] id: UBERON:0001234 name: left adrenal gland def: "An adrenal gland that is in the left side of the abdomen." [OBOL:automatic] synonym: "glandula suprarenalis sinister" EXACT OMO:0003011 [] synonym: "left suprarenal gland" EXACT [] xref: EMAPA:37356 {source="MA:th"} xref: FMA:15630 xref: MA:0000718 xref: NCIT:C49322 xref: SCTID:281626000 xref: UMLS:C0229560 {source="ncithesaurus:Left_Adrenal_Gland"} is_a: UBERON:0002369 ! adrenal gland intersection_of: UBERON:0002369 ! adrenal gland intersection_of: BSPO:0000120 UBERON:0000916 ! abdomen relationship: BSPO:0000120 UBERON:0000916 ! abdomen [Term] id: UBERON:0001235 name: adrenal cortex def: "The thick outer layer of the adrenal gland that produces and secretes steroid hormones such as corticosterone, estrone and aldosterone." [ISBN:0-683-40008-8, MGI:llw2, MP:0008288] subset: efo_slim subset: pheno_slim subset: uberon_slim synonym: "adrenal gland cortex" EXACT [] synonym: "cortex (glandula suprarenalis)" EXACT [] synonym: "cortex glandulae suprarenalis" RELATED OMO:0003011 [BTO:0000045, Wikipedia:Adrenal_cortex] synonym: "cortex of adrenal gland" EXACT [] synonym: "cortex of suprarenal gland" EXACT [] synonym: "suprarenal" RELATED [] synonym: "suprarenal cortex" EXACT [] xref: AAO:0011009 xref: BTO:0000045 xref: CALOHA:TS-0015 xref: EFO:0000237 xref: EMAPA:18427 xref: EV:0100136 xref: FMA:15632 xref: GAID:447 xref: MA:0000118 xref: MAT:0000494 xref: MESH:D000302 xref: NCIT:C12396 xref: SCTID:362584002 xref: UMLS:C0001613 {source="ncithesaurus:Adrenal_Cortex"} xref: VHOG:0001481 xref: Wikipedia:Adrenal_cortex xref: XAO:0000165 is_a: UBERON:0001851 ! cortex is_a: UBERON:0004120 ! mesoderm-derived structure intersection_of: UBERON:0001851 ! cortex intersection_of: BFO:0000050 UBERON:0002369 ! part of adrenal gland relationship: BFO:0000050 UBERON:0002369 ! part of adrenal gland relationship: RO:0002215 GO:0006704 ! capable of glucocorticoid biosynthetic process relationship: RO:0002215 GO:0006705 ! capable of mineralocorticoid biosynthetic process relationship: RO:0002215 GO:0035932 ! capable of aldosterone secretion relationship: RO:0002433 UBERON:0002369 ! contributes to morphology of adrenal gland property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/5/5c/Gray1185.png" xsd:anyURI [Term] id: UBERON:0001236 name: adrenal medulla def: "The inner portion of the adrenal gland that consists mainly of chromaffin cells which produce, store and secrete neurotransmitters such as epinephrine and norepinephrine." [MESH:A06.407.071.265, MGI:llw2, MP:0008289] subset: efo_slim subset: pheno_slim subset: uberon_slim synonym: "adrenal central medulla" RELATED [] synonym: "adrenal gland medulla" EXACT [] synonym: "chromaffin cells" RELATED [] synonym: "medulla (glandula suprarenalis)" EXACT [] synonym: "medulla glandulae suprarenalis" EXACT OMO:0003011 [FMA:15633, FMA:TA] synonym: "medulla of adrenal gland" EXACT [OBOL:automatic] synonym: "medulla of glandula suprarenalis" RELATED [BTO:0000049] synonym: "medulla of suprarenal gland" EXACT [] synonym: "suprarenal medulla" EXACT [] xref: AAO:0011010 xref: BTO:0000049 xref: CALOHA:TS-0018 xref: EFO:0000852 xref: EMAPA:18428 xref: EV:0100137 xref: FMA:15633 xref: GAID:451 xref: MA:0000119 xref: MAT:0000495 xref: MESH:D019439 xref: NCIT:C12397 xref: SCTID:362585001 xref: UMLS:C0001629 {source="ncithesaurus:Adrenal_Medulla"} xref: VHOG:0001378 xref: Wikipedia:Adrenal_medulla xref: XAO:0000166 is_a: UBERON:0000958 ! medulla of organ is_a: UBERON:0010313 ! neural crest-derived structure intersection_of: UBERON:0000958 ! medulla of organ intersection_of: BFO:0000050 UBERON:0002369 ! part of adrenal gland relationship: BFO:0000050 UBERON:0002369 ! part of adrenal gland relationship: BFO:0000051 CL:0002082 {source="FMA"} ! has part type II cell of adrenal medulla relationship: BFO:0000051 CL:0002083 {source="FMA"} ! has part type I cell of adrenal medulla relationship: RO:0002219 UBERON:0001235 {source="Wikipedia"} ! surrounded by adrenal cortex relationship: RO:0002433 UBERON:0002369 ! contributes to morphology of adrenal gland property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/5/5c/Gray1185.png" xsd:anyURI [Term] id: UBERON:0001237 name: paraaortic body def: "A chromaffin paraganglion located at the bifurcation of the aorta or at the origin of the inferior mesenteric artery." [Wikipedia:Organ_of_Zuckerkandl] comment: The largest chromaffin paraganglia, and the largest source of circulating catecholamines in the fetus and young infants, and gradually atrophies to microscopic loci[WP] subset: organ_slim subset: uberon_slim synonym: "organ of Zuckerkandl" EXACT [] synonym: "para-aortic body" RELATED [] synonym: "paraganglia of Zuckerkandl" RELATED OMO:0003004 [] synonym: "paraganglion of Zuckerkandl" EXACT [EMAPA:18223] xref: EMAPA:18223 xref: FMA:15647 xref: GAID:444 xref: MA:0001137 xref: MESH:D010220 xref: NCIT:C25316 xref: SCTID:276159005 xref: UMLS:C0442134 {source="ncithesaurus:Paraaortic"} xref: Wikipedia:Organ_of_Zuckerkandl is_a: UBERON:0012279 ! chromaffin paraganglion property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/a/af/Gray531.png" xsd:anyURI [Term] id: UBERON:0001238 name: lamina propria of small intestine def: "Lamina propria that is part_of the small intestine." [GOC:Obol] synonym: "lamina propria mucosa of small bowel" EXACT [OBOL:automatic] synonym: "lamina propria mucosa of small intestine" EXACT [OBOL:automatic] synonym: "lamina propria mucosae of small bowel" EXACT [OBOL:automatic] synonym: "lamina propria mucosae of small intestine" EXACT [] synonym: "lamina propria of mucosa of small intestine" EXACT [] synonym: "lamina propria of small bowel" EXACT [OBOL:automatic] synonym: "small bowel lamina propria" EXACT [OBOL:automatic] synonym: "small bowel lamina propria mucosa" EXACT [OBOL:automatic] synonym: "small bowel lamina propria mucosae" EXACT [OBOL:automatic] synonym: "small intestine lamina propria" EXACT [] synonym: "small intestine lamina propria mucosa" EXACT [OBOL:automatic] synonym: "small intestine lamina propria mucosae" EXACT [OBOL:automatic] xref: EMAPA:35779 xref: FMA:15651 xref: MA:0001554 xref: NCIT:C49297 xref: SCTID:63588008 xref: UMLS:C1711325 {source="ncithesaurus:Small_Intestinal_Lamina_Propria"} is_a: UBERON:0004780 ! gastrointestinal system lamina propria intersection_of: UBERON:0000030 ! lamina propria intersection_of: BFO:0000050 UBERON:0002108 ! part of small intestine relationship: BFO:0000050 UBERON:0001204 ! part of mucosa of small intestine property_value: skos:prefLabel "lamina propria of small intestine" xsd:string [Term] id: UBERON:0001239 name: muscularis mucosae of large intestine def: "A muscularis mucosa that is part of a large intestine." [OBOL:automatic] synonym: "lamina muscularis mucosae intestini crassi" EXACT OMO:0003011 [FMA:15655, FMA:TA] synonym: "lamina muscularis of large intestine mucosa" EXACT [] synonym: "lamina muscularis of large intestine mucous membrane" EXACT [] synonym: "large intestine muscularis mucosa" EXACT [] xref: EMAPA:37556 {source="MA:th"} xref: FMA:15655 xref: MA:0002689 xref: NCIT:C32928 xref: UMLS:C0734776 {source="ncithesaurus:Large_Intestinal_Muscularis_Mucosa"} is_a: UBERON:0001240 ! muscularis mucosae of intestine is_a: UBERON:0004220 ! large intestine smooth muscle intersection_of: UBERON:0006676 ! muscularis mucosa intersection_of: BFO:0000050 UBERON:0000059 ! part of large intestine relationship: BFO:0000050 UBERON:0001207 ! part of mucosa of large intestine relationship: BFO:0000050 UBERON:0001240 ! part of muscularis mucosae of intestine [Term] id: UBERON:0001240 name: muscularis mucosae of intestine def: "A muscularis mucosa that is part of a intestine." [OBOL:automatic] synonym: "intestinal muscularis mucosa" RELATED [EMAPA:35442] synonym: "intestine muscularis mucosa" EXACT [MA:0002694] xref: EMAPA:35442 xref: FMA:15691 xref: MA:0002694 is_a: UBERON:0004221 ! intestine smooth muscle is_a: UBERON:0006676 ! muscularis mucosa intersection_of: UBERON:0006676 ! muscularis mucosa intersection_of: BFO:0000050 UBERON:0000160 ! part of intestine relationship: BFO:0000050 UBERON:0001242 ! part of intestinal mucosa [Term] id: UBERON:0001241 name: crypt of Lieberkuhn of small intestine def: "The tubular intestinal glands found in the mucosal membranes of the small intestine." [ISBN:0-683-40008-8, MP:0004841] subset: pheno_slim synonym: "crypt of Lieberkuhn of small bowel" EXACT [OBOL:automatic] synonym: "crypt of Lieberkuhn of small intestine" EXACT [OBOL:automatic] synonym: "intestinal gland of small bowel" EXACT [OBOL:automatic] synonym: "intestinal gland of small intestine" EXACT [OBOL:automatic] synonym: "Lieberkühn crypt of small bowel" EXACT [OBOL:automatic] synonym: "Lieberkühn crypt of small intestine" EXACT [OBOL:automatic] synonym: "small bowel crypt of Lieberkuhn" EXACT [OBOL:automatic] synonym: "small bowel intestinal gland" EXACT [OBOL:automatic] synonym: "small bowel Lieberkühn crypt" EXACT [OBOL:automatic] synonym: "small intestinal crypt of Lieberkuhn" EXACT [] synonym: "small intestine crypt of Lieberkuhn" EXACT [OBOL:automatic] synonym: "small intestine intestinal gland" EXACT [OBOL:automatic] synonym: "small intestine Lieberkühn crypt" EXACT [OBOL:automatic] xref: EMAPA:35777 xref: FMA:15693 xref: MA:0001552 xref: NCIT:C33565 xref: SCTID:52688008 xref: UMLS:C0227267 {source="ncithesaurus:Small_Intestinal_Crypt_of_Lieberkuhn"} is_a: UBERON:0001983 ! crypt of Lieberkuhn intersection_of: UBERON:0001983 ! crypt of Lieberkuhn intersection_of: BFO:0000050 UBERON:0002108 ! part of small intestine relationship: BFO:0000050 UBERON:0002108 ! part of small intestine relationship: RO:0002433 UBERON:0002108 ! contributes to morphology of small intestine [Term] id: UBERON:0001242 name: intestinal mucosa def: "Mucosal layer that lines the intestine." [UBERON:cjm] subset: pheno_slim subset: uberon_slim synonym: "bowel mucosa" EXACT [OBOL:automatic] synonym: "bowel mucosa of organ" EXACT [OBOL:automatic] synonym: "bowel mucous membrane" EXACT [OBOL:automatic] synonym: "bowel organ mucosa" EXACT [OBOL:automatic] synonym: "intestine mucosa" EXACT [] synonym: "intestine mucosa of organ" EXACT [OBOL:automatic] synonym: "intestine mucous membrane" EXACT [OBOL:automatic] synonym: "intestine organ mucosa" EXACT [OBOL:automatic] synonym: "mucosa of bowel" EXACT [OBOL:automatic] synonym: "mucosa of intestine" EXACT [] synonym: "mucosa of organ of bowel" EXACT [OBOL:automatic] synonym: "mucosa of organ of intestine" EXACT [OBOL:automatic] synonym: "mucous membrane of bowel" EXACT [OBOL:automatic] synonym: "mucous membrane of intestine" EXACT [OBOL:automatic] synonym: "organ mucosa of bowel" EXACT [OBOL:automatic] synonym: "organ mucosa of intestine" EXACT [OBOL:automatic] synonym: "tunica mucosa intestini" EXACT [] xref: BTO:0000642 xref: EMAPA:35440 xref: FMA:15695 xref: GAID:296 xref: MA:0001537 xref: MESH:D007413 xref: NCIT:C49241 xref: SCTID:362080002 xref: UMLS:C0021839 {source="ncithesaurus:Intestinal_Mucosa"} is_a: UBERON:0004786 ! gastrointestinal system mucosa intersection_of: UBERON:0000344 ! mucosa intersection_of: BFO:0000050 UBERON:0000160 ! part of intestine relationship: BFO:0000050 UBERON:0001262 ! part of wall of intestine property_value: skos:prefLabel "intestinal mucosa" xsd:string [Term] id: UBERON:0001243 name: serosa of intestine def: "A serous membrane that is part of a wall of intestine [Automatically generated definition]." [OBOL:automatic] synonym: "anatomical wall of bowel serosa" EXACT [OBOL:automatic] synonym: "anatomical wall of bowel serous membrane" EXACT [OBOL:automatic] synonym: "anatomical wall of intestine serosa" EXACT [OBOL:automatic] synonym: "anatomical wall of intestine serous membrane" EXACT [OBOL:automatic] synonym: "bowel anatomical wall serosa" EXACT [OBOL:automatic] synonym: "bowel anatomical wall serous membrane" EXACT [OBOL:automatic] synonym: "bowel wall serosa" EXACT [OBOL:automatic] synonym: "bowel wall serous membrane" EXACT [OBOL:automatic] synonym: "intestinal serosa" EXACT [] synonym: "intestinal wall serosa" EXACT [OBOL:automatic] synonym: "intestinal wall serous membrane" EXACT [OBOL:automatic] synonym: "intestine anatomical wall serosa" EXACT [OBOL:automatic] synonym: "intestine anatomical wall serous membrane" EXACT [OBOL:automatic] synonym: "intestine serosa" EXACT [] synonym: "intestine wall serosa" EXACT [OBOL:automatic] synonym: "intestine wall serous membrane" EXACT [OBOL:automatic] synonym: "serosa of anatomical wall of bowel" EXACT [OBOL:automatic] synonym: "serosa of anatomical wall of intestine" EXACT [OBOL:automatic] synonym: "serosa of bowel anatomical wall" EXACT [OBOL:automatic] synonym: "serosa of bowel wall" EXACT [OBOL:automatic] synonym: "serosa of intestinal wall" EXACT [OBOL:automatic] synonym: "serosa of intestine anatomical wall" EXACT [OBOL:automatic] synonym: "serosa of intestine wall" EXACT [OBOL:automatic] synonym: "serosa of wall of bowel" EXACT [OBOL:automatic] synonym: "serosa of wall of intestine" EXACT [OBOL:automatic] synonym: "serous membrane of anatomical wall of bowel" EXACT [OBOL:automatic] synonym: "serous membrane of anatomical wall of intestine" EXACT [OBOL:automatic] synonym: "serous membrane of bowel anatomical wall" EXACT [OBOL:automatic] synonym: "serous membrane of bowel wall" EXACT [OBOL:automatic] synonym: "serous membrane of intestinal wall" EXACT [OBOL:automatic] synonym: "serous membrane of intestine anatomical wall" EXACT [OBOL:automatic] synonym: "serous membrane of intestine wall" EXACT [OBOL:automatic] synonym: "serous membrane of wall of bowel" EXACT [OBOL:automatic] synonym: "serous membrane of wall of intestine" EXACT [OBOL:automatic] synonym: "visceral peritoneum of intestine" EXACT [] synonym: "wall of bowel serosa" EXACT [OBOL:automatic] synonym: "wall of bowel serous membrane" EXACT [OBOL:automatic] synonym: "wall of intestine serosa" EXACT [OBOL:automatic] synonym: "wall of intestine serous membrane" EXACT [OBOL:automatic] xref: EMAPA:37619 {source="MA:th"} xref: FMA:15701 xref: MA:0001538 is_a: UBERON:0004782 ! gastrointestinal system serosa intersection_of: UBERON:0000042 ! serous membrane intersection_of: BFO:0000050 UBERON:0000160 ! part of intestine relationship: BFO:0000050 UBERON:0001262 ! part of wall of intestine property_value: IAO:0000116 "TODO - check serosa/peritoneum" xsd:string property_value: skos:prefLabel "serosa of intestine" xsd:string [Term] id: UBERON:0001245 name: anus def: "Orifice at the opposite end of an animal's digestive tract from the mouth. Its function is to expel feces, unwanted semi-solid matter produced during digestion, which, depending on the type of animal, may be one or more of: matter which the animal cannot digest, such as bones; food material after all the nutrients have been extracted, for example cellulose or lignin; ingested matter which would be toxic if it remained in the digestive tract; and dead or excess gut bacteria and other endosymbionts." [Wikipedia:Anus, ZFIN:curator] subset: human_reference_atlas subset: pheno_slim subset: uberon_slim synonym: "anal opening" EXACT [] synonym: "anal orifice" EXACT [] synonym: "opening of terminal part of digestive tract" EXACT [] synonym: "proctodeum" RELATED [] xref: BTO:0001680 xref: CALOHA:TS-2005 xref: EV:0100082 xref: FBbt:00047153 {sssom:mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"} xref: FMA:15711 xref: GAID:312 xref: galen:Anus xref: MA:0000331 xref: NCIT:C43362 xref: SCTID:181262009 xref: TADS:0000066 xref: TGMA:0001279 xref: UMLS:C0003461 {source="ncithesaurus:Anus"} xref: WBbt:0005364 xref: Wikipedia:Anus is_a: UBERON:0000161 ! orifice is_a: UBERON:0004121 ! ectoderm-derived structure intersection_of: UBERON:0000161 ! orifice intersection_of: BSPO:0001108 UBERON:0001555 ! digestive tract relationship: BSPO:0001108 UBERON:0001555 ! digestive tract relationship: RO:0002202 UBERON:0000931 ! develops from proctodeum property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/6/65/Protovsdeuterostomes.svg" xsd:anyURI property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/7/75/Anorectum.gif" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "anus" xsd:string [Term] id: UBERON:0001246 name: interlobular bile duct def: "The canals that carry bile in the liver between the intralobular ducts and the biliary ductules; interlobular bile ducts are part of the interlobular portal triad." [MP:0009500] subset: pheno_slim synonym: "interlobular ductule" EXACT [MP:0009500] xref: FMA:15767 xref: MA:0002668 xref: NCIT:C32827 xref: SCTID:83488001 xref: UMLS:C0227515 {source="ncithesaurus:Interlobular_Bile_Duct"} xref: Wikipedia:Interlobular_bile_ducts is_a: UBERON:0003704 {source="FMA", source="MA-part-of"} ! intrahepatic bile duct relationship: BFO:0000050 UBERON:0001279 {source="FMA", source="MA", source="MP"} ! part of portal triad relationship: RO:0002176 UBERON:0004058 ! connects biliary ductule relationship: RO:0002176 UBERON:0014719 ! connects intralobular duct relationship: RO:0002433 UBERON:0001279 ! contributes to morphology of portal triad property_value: skos:prefLabel "interlobular bile duct" xsd:string [Term] id: UBERON:0001247 name: falciform ligament def: "A ligament that attaches the liver to the anterior body wall. It is a broad and thin antero-posterior peritoneal fold, falciform in shape, its base being directed downward and backward and its apex upward and backward. It is a remnant of the ventral mesentery of the fetus. It is situated in an antero-posterior plane but lies obliquely, so that one surface faces forward and is in contact with the peritoneum behind the right rectus and the diaphragm, while the other is directed backward and is in contact with the left lobe of the liver. It is attached by its left margin to the under surface of the diaphragm and the posterior surface of the sheath of the right Rectus as low down as the umbilicus; by its right margin it extends from the notch on the anterior margin of the liver, as far back as the posterior surface. It is composed of two layers of peritoneum closely united together. Its base or free edge contains between its layers the round ligament and the paraumbilical veins[WP]." [Wikipedia:Falciform_ligament] subset: uberon_slim synonym: "falciform ligament of liver" EXACT [] synonym: "ligamentum falciforme (hepatis)" EXACT [] synonym: "ligamentum falciforme hepatis" EXACT OMO:0003011 [FMA:15823, FMA:TA] xref: EHDAA2:0000499 xref: EHDAA:4856 xref: EMAPA:18288 xref: FMA:15823 xref: MA:0001622 xref: NCIT:C32582 xref: SCTID:362705001 xref: UMLS:C0230240 {source="ncithesaurus:Falciform_Ligament"} xref: VHOG:0000355 xref: Wikipedia:Falciform_ligament is_a: UBERON:0013139 ! ligament of liver intersection_of: UBERON:0008845 ! nonskeletal ligament intersection_of: RO:0002371 UBERON:0000309 ! attached to body wall intersection_of: RO:0002371 UBERON:0002107 ! attached to liver relationship: BFO:0000050 UBERON:0005626 {source="MA"} ! part of ventral mesogastrium relationship: RO:0002371 UBERON:0000309 ! attached to body wall relationship: RO:0002371 UBERON:0002107 ! attached to liver property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/liver-female/v1.2/assets/3d-vh-f-liver.glb" xsd:anyURI property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/liver-male/v1.2/assets/3d-vh-m-liver.glb" xsd:anyURI [Term] id: UBERON:0001249 name: spleen lymphoid follicle def: "The area of the white pulp where the affinity maturation of B cells and the generation of memory B cells and plasma cells occur." [CL:tm, https://github.com/obophenotype/uberon/issues/6, MP:0008470] subset: pheno_slim synonym: "lymphatic follicle of spleen" EXACT [FMA:15843] synonym: "lymphoid follicle of spleen" EXACT [FMA:15843] synonym: "lymphoid nodule of spleen" EXACT [FMA:15843] synonym: "Malpighian body" EXACT [FMA:15843] synonym: "spleen B cell follicle" EXACT [CL:tm] synonym: "spleen lymphoid follicle" EXACT [MA:0002672] synonym: "spleen lymphoid nodule" RELATED [MA:0002672] synonym: "splenic B cell follicle" EXACT [CL:tm] synonym: "splenic lymphatic follicle" EXACT [FMA:15843] synonym: "splenic lymphoid follicle" EXACT [] xref: EMAPA:35804 xref: MA:0002672 xref: NCIT:C33602 xref: SCTID:35845000 xref: UMLS:C1519475 {source="ncithesaurus:Splenic_Lymphoid_Follicle"} is_a: UBERON:0000444 ! lymphoid follicle intersection_of: UBERON:0000444 ! lymphoid follicle intersection_of: BFO:0000050 UBERON:0002106 ! part of spleen relationship: BFO:0000050 UBERON:0001959 {source="CL:tm", source="MA"} ! part of white pulp of spleen relationship: BFO:0000050 UBERON:0006561 {source="FMA"} ! part of non-lymphatic part of lymphoid system relationship: BFO:0000067 GO:0002319 ! contains process memory B cell differentiation relationship: RO:0002433 UBERON:0001959 ! contributes to morphology of white pulp of spleen property_value: terms:contributor https://orcid.org/0000-0002-6601-2165 property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 [Term] id: UBERON:0001250 name: red pulp of spleen def: "The parenchymatous tissue network of the spleen that consists of loose plates or cords (sinuses) infiltrated with red blood cells where most of the blood filtration occurs and degenerate erythrocytes are removed from the circulation." [MGI:csmith, MP:0002356] subset: human_reference_atlas subset: pheno_slim subset: uberon_slim synonym: "pulpa rubra" EXACT OMO:0003011 [FMA:15844, FMA:TA] synonym: "pulpa splenica" RELATED OMO:0003011 [Wikipedia:Red_pulp] synonym: "red pulp" EXACT [] synonym: "spleen red pulp" EXACT [] synonym: "splenic red pulp" EXACT [] xref: CALOHA:TS-1263 xref: EMAPA:35806 xref: FMA:15844 xref: MA:0000756 xref: NCIT:C12992 xref: SCTID:27579002 xref: UMLS:C0229687 {source="ncithesaurus:Splenic_Red_Pulp"} xref: Wikipedia:Red_pulp is_a: BFO:0000002 is_a: UBERON:1000023 ! spleen pulp relationship: RO:0002433 UBERON:0002106 ! contributes to morphology of spleen relationship: RO:0002473 CL:0000542 ! composed primarily of lymphocyte property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/1/15/Gray1191.png" xsd:anyURI property_value: RO:0002175 NCBITaxon:7955 {source="DOI:10.1177/0192623311409597"} property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001251 name: marginal zone of spleen def: "The zone between the red and white pulp of the spleen containing numerous macrophages and lymphocytes, and a rich plexus of sinusoids supplied by white pulp arterioles carrying blood-borne antigens." [ISBN:0-683-40008-8, MP:0002362] subset: human_reference_atlas subset: pheno_slim synonym: "junctional zone of spleen" EXACT [] synonym: "marginal zone" BROAD [Wikipedia:Marginal_zone] synonym: "spleen marginal zone" EXACT [MA:0000755] xref: CALOHA:TS-2395 xref: EMAPA:36650 xref: FMA:15852 xref: MA:0000755 xref: NCIT:C49767 xref: UMLS:C1711368 {source="ncithesaurus:Marginal_Zone"} xref: Wikipedia:Marginal_zone is_a: UBERON:0000064 ! organ part relationship: BFO:0000050 UBERON:0002106 ! part of spleen relationship: RO:0002220 UBERON:0001250 ! adjacent to red pulp of spleen relationship: RO:0002220 UBERON:0001959 ! adjacent to white pulp of spleen property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/1/15/Gray1191.png" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001252 name: adventitia of ureter def: "An adventitia that is part of a ureter." [OBOL:automatic] synonym: "external adventitia of ureter" EXACT [] synonym: "tunica adventitia (ureter)" EXACT OMO:0003011 [FMA:15892, FMA:TA] synonym: "tunica adventitia ureteris" EXACT OMO:0003011 [FMA:15892, FMA:TA] synonym: "ureter adventitia" EXACT [] synonym: "ureteral adventitia" EXACT [] xref: EMAPA:28114 xref: FMA:15892 xref: MA:0002652 xref: SCTID:392273001 xref: SCTID:47879001 is_a: UBERON:0005742 ! adventitia intersection_of: UBERON:0005742 ! adventitia intersection_of: BFO:0000050 UBERON:0000056 ! part of ureter relationship: BFO:0000050 UBERON:0009916 {source="https://github.com/obophenotype/uberon/wiki/Inferring-part-of-relationships"} ! part of wall of ureter [Term] id: UBERON:0001253 name: lamina propria of ureter def: "A lamina propria that is part of a ureter [Automatically generated definition]." [OBOL:automatic] subset: human_reference_atlas synonym: "lamina propria mucosa of ureter" EXACT [OBOL:automatic] synonym: "lamina propria mucosae of ureter" EXACT [OBOL:automatic] synonym: "ureter lamina propria" EXACT [] synonym: "ureter lamina propria mucosa" EXACT [OBOL:automatic] synonym: "ureter lamina propria mucosae" EXACT [OBOL:automatic] xref: EMAPA:28841 xref: FMA:15896 xref: MA:0002653 xref: SCTID:2771005 is_a: UBERON:0000030 ! lamina propria intersection_of: UBERON:0000030 ! lamina propria intersection_of: BFO:0000050 UBERON:0000056 ! part of ureter relationship: BFO:0000050 UBERON:0004980 {is_inferred="true", source="https://github.com/obophenotype/uberon/wiki/Inferring-part-of-relationships"} ! part of mucosa of ureter property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001254 name: urothelium of ureter def: "The luminal epithelium of the tube that conducts the urine from the renal pelvis to the bladder[MP]." [MP:0000535] subset: human_reference_atlas subset: pheno_slim synonym: "transitional epithelium of ureter" EXACT [] synonym: "ureter luminal urothelium" RELATED INCONSISTENT [MP:0000535] synonym: "ureter transitional epithelium" EXACT [] synonym: "ureter urothelium" EXACT [] xref: EMAPA:28089 xref: FMA:15897 xref: MA:0002655 is_a: UBERON:0000365 ! urothelium intersection_of: UBERON:0000365 ! urothelium intersection_of: BFO:0000050 UBERON:0000056 ! part of ureter relationship: BFO:0000050 UBERON:0000056 ! part of ureter relationship: RO:0002433 UBERON:0000056 ! contributes to morphology of ureter property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001255 name: urinary bladder def: "Distensible musculomembranous organ situated in the anterior part of the pelvic cavity in which urine collects before excretion[MP]." [MGI:anna, Wikipedia:Urinary_bladder] subset: efo_slim subset: human_reference_atlas subset: major_organ subset: organ_slim subset: pheno_slim subset: uberon_slim synonym: "bladder" BROAD [EHDAA2:0000174] synonym: "urocyst" RELATED [Wikipedia:Urinary_bladder] synonym: "vesica" RELATED [BTO:0001418] synonym: "vesica urinaria" EXACT OMO:0003011 [Wikipedia:Urinary_bladder] xref: AAO:0000623 xref: BTO:0001418 xref: CALOHA:TS-1090 xref: EFO:0000290 xref: EHDAA2:0000174 xref: EHDAA:9328 xref: EMAPA:18321 xref: EV:0100098 xref: FMA:15900 xref: GAID:0000004 xref: galen:UrinaryBladder xref: MA:0000380 xref: MAT:0000122 xref: MESH:D001743 xref: MIAA:0000122 xref: NCIT:C12414 xref: SCTID:302512001 xref: UMLS:C0005682 {source="ncithesaurus:Bladder"} xref: VHOG:0000740 xref: Wikipedia:Urinary_bladder xref: XAO:0000154 is_a: UBERON:0002075 ! viscus is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0018707 {source="BTO"} ! bladder organ relationship: BFO:0000050 UBERON:0001556 {source="FMA"} ! part of lower urinary tract relationship: RO:0002202 UBERON:0000164 ! develops from primitive urogenital sinus property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/urinary-bladder-female/v1.2/assets/3d-vh-f-urinary-bladder.glb" xsd:anyURI property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/urinary-bladder-male/v1.2/assets/3d-vh-m-urinary-bladder.glb" xsd:anyURI property_value: foaf:depiction "https://upload.wikimedia.org/wikipedia/commons/3/30/Urinary_system.svg" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001256 name: wall of urinary bladder def: "An anatomical wall that lines the insider of a urinary bladder." [http://orcid.org/0000-0002-6601-2165] subset: human_reference_atlas subset: pheno_slim synonym: "anatomical wall of bladder" EXACT [OBOL:automatic] synonym: "anatomical wall of urinary bladder" EXACT [OBOL:automatic] synonym: "bladder anatomical wall" EXACT [OBOL:automatic] synonym: "bladder wall" EXACT [OBOL:automatic] synonym: "urinary bladder anatomical wall" EXACT [OBOL:automatic] synonym: "urinary bladder wall" EXACT [] synonym: "wall of bladder" EXACT [OBOL:automatic] xref: BTO:0001462 xref: EMAPA:35175 xref: FMA:15902 xref: MA:0002493 xref: NCIT:C48941 xref: SCTID:362225003 xref: UMLS:C0458421 {source="ncithesaurus:Bladder_Wall"} is_a: UBERON:0000060 ! anatomical wall intersection_of: UBERON:0000060 ! anatomical wall intersection_of: BFO:0000050 UBERON:0001255 ! part of urinary bladder relationship: BFO:0000050 UBERON:0001255 ! part of urinary bladder property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001257 name: trigone of urinary bladder def: "The smooth triangular region of the wall of the urinary bladder formed by the two ureteral orifices and the internal urethral orifice; it is an area in which the muscle fibers are closely adherent to the mucosa." [MGI:anna, MP:0011768] subset: human_reference_atlas subset: pheno_slim subset: uberon_slim synonym: "bladder trigone" EXACT [] synonym: "deep trigone" EXACT [] synonym: "dorsal bladder neck" RELATED [EMAPA:35174] synonym: "Lieutaud's trigone" EXACT [] synonym: "musculus trigoni vesicae profundus" EXACT OMO:0003011 [FMA:15910, FMA:TA] synonym: "trigone of bladder" EXACT [] synonym: "trigonum vesicae" EXACT OMO:0003011 [FMA:15910, FMA:TA] synonym: "trigonum vesicae urinariae" RELATED OMO:0003011 [Wikipedia:Trigone_of_urinary_bladder] synonym: "urinary bladder trigone" EXACT [] synonym: "vesical trigone" EXACT [] xref: EMAPA:35174 xref: FMA:15910 xref: galen:TrigoneOfUrinaryBladder xref: MA:0002492 xref: NCIT:C12331 xref: SCTID:272663002 xref: UMLS:C0447586 {source="ncithesaurus:Bladder_Trigone"} xref: Wikipedia:Trigone_of_urinary_bladder is_a: UBERON:0000064 ! organ part relationship: BFO:0000050 UBERON:0006082 ! part of fundus of urinary bladder relationship: RO:0002433 UBERON:0001255 ! contributes to morphology of urinary bladder property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/urinary-bladder-female/v1.2/assets/3d-vh-f-urinary-bladder.glb" xsd:anyURI property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/urinary-bladder-male/v1.2/assets/3d-vh-m-urinary-bladder.glb" xsd:anyURI property_value: foaf:depiction "https://upload.wikimedia.org/wikipedia/commons/5/57/Illu_bladder.jpg" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001258 name: neck of urinary bladder def: "The constricted portion of the urinary bladder, formed by the meeting of its inferolateral surfaces proximal to the opening of the urethra[MP]." [MP:anna, Wikipedia:Neck_of_urinary_bladder] subset: pheno_slim subset: uberon_slim synonym: "bladder neck" EXACT [] synonym: "cervix vesicae" EXACT OMO:0003011 [FMA:15912, FMA:TA] synonym: "cervix vesicae urinariae" RELATED OMO:0003011 [Wikipedia:Neck_of_urinary_bladder] synonym: "collum vesicae" EXACT OMO:0003011 [FMA:15912, FMA:TA] synonym: "neck of bladder" EXACT [] synonym: "urinary bladder neck" EXACT [] synonym: "vesical neck" EXACT [] xref: EMAPA:36078 xref: FMA:15912 xref: galen:UrinaryBladderNeck xref: MA:0002491 xref: NCIT:C12336 xref: SCTID:362227006 xref: UMLS:C0227716 {source="ncithesaurus:Bladder_Neck"} xref: Wikipedia:Neck_of_urinary_bladder is_a: UBERON:0001560 ! neck of organ intersection_of: UBERON:0001560 ! neck of organ intersection_of: BFO:0000050 UBERON:0001255 ! part of urinary bladder relationship: BFO:0000050 UBERON:0001255 ! part of urinary bladder relationship: RO:0002433 UBERON:0001255 ! contributes to morphology of urinary bladder property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/6/63/Gray1156.png" xsd:anyURI [Term] id: UBERON:0001259 name: mucosa of urinary bladder def: "The mucous membrane lining the urinary bladder." [MGI:anna, MP:0011766] subset: efo_slim subset: human_reference_atlas subset: pheno_slim synonym: "bladder mucosa" EXACT [] synonym: "bladder mucous membrane" EXACT [OBOL:automatic] synonym: "bladder organ mucosa" EXACT [OBOL:automatic] synonym: "mucosa of bladder" EXACT [OBOL:automatic] synonym: "mucous membrane of bladder" EXACT [] synonym: "mucous membrane of urinary bladder" EXACT [] synonym: "tunica mucosa (vesica urinaria)" EXACT OMO:0003011 [FMA:15928, FMA:TA] synonym: "tunica mucosa vesicae" EXACT OMO:0003011 [FMA:15928, FMA:TA] synonym: "tunica mucosa vesicae urinariae" EXACT [MP:MP] synonym: "urinary bladder mucosa" EXACT [] synonym: "urinary bladder mucous membrane" EXACT [OBOL:automatic] xref: EFO:0000293 xref: EMAPA:35897 xref: FMA:15928 xref: galen:MucousMembraneOfUrinaryBladder xref: MA:0001692 xref: NCIT:C32205 xref: SCTID:362224004 xref: UMLS:C0227691 {source="ncithesaurus:Bladder_Mucosa"} is_a: UBERON:0000344 ! mucosa intersection_of: UBERON:0000344 ! mucosa intersection_of: BFO:0000050 UBERON:0001255 ! part of urinary bladder relationship: BFO:0000050 UBERON:0001256 ! part of wall of urinary bladder relationship: RO:0002433 UBERON:0001255 ! contributes to morphology of urinary bladder property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001260 name: serosa of urinary bladder def: "A serous membrane that is part of a urinary bladder [Automatically generated definition]." [OBOL:automatic] synonym: "bladder serosa" EXACT [] synonym: "bladder serous membrane" EXACT [OBOL:automatic] synonym: "serosa of bladder" EXACT [] synonym: "serous coat of bladder" EXACT [] synonym: "serous coat of urinary bladder" EXACT [] synonym: "serous membrane of bladder" EXACT [OBOL:automatic] synonym: "serous membrane of urinary bladder" EXACT [OBOL:automatic] synonym: "tunica serosa (vesica urinaria)" EXACT OMO:0003011 [FMA:15932, FMA:TA] synonym: "tunica serosa vesicae" EXACT OMO:0003011 [FMA:15932, FMA:TA] synonym: "urinary bladder serosa" EXACT [] synonym: "urinary bladder serous membrane" EXACT [OBOL:automatic] synonym: "visceral peritoneum of urinary bladder" EXACT [] xref: EMAPA:28661 xref: FMA:15932 xref: MA:0001696 xref: SCTID:5868002 is_a: UBERON:0000042 ! serous membrane intersection_of: UBERON:0000042 ! serous membrane intersection_of: BFO:0000050 UBERON:0001255 ! part of urinary bladder relationship: BFO:0000050 UBERON:0001256 {source="https://github.com/obophenotype/uberon/wiki/Inferring-part-of-relationships"} ! part of wall of urinary bladder property_value: IAO:0000116 "TODO - check serosa/peritoneum" xsd:string [Term] id: UBERON:0001261 name: lamina propria of urinary bladder def: "A lamina propria that is part of a urinary bladder [Automatically generated definition]." [OBOL:automatic] subset: human_reference_atlas synonym: "bladder lamina propria" EXACT [OBOL:automatic] synonym: "bladder lamina propria mucosa" EXACT [OBOL:automatic] synonym: "bladder lamina propria mucosae" EXACT [OBOL:automatic] synonym: "lamina propria mucosa of bladder" EXACT [OBOL:automatic] synonym: "lamina propria mucosa of urinary bladder" EXACT [OBOL:automatic] synonym: "lamina propria mucosae of bladder" EXACT [OBOL:automatic] synonym: "lamina propria mucosae of urinary bladder" EXACT [OBOL:automatic] synonym: "lamina propria of bladder" EXACT [OBOL:automatic] synonym: "urinary bladder lamina propria" EXACT [] synonym: "urinary bladder lamina propria mucosa" EXACT [OBOL:automatic] synonym: "urinary bladder lamina propria mucosae" EXACT [OBOL:automatic] xref: EMAPA:30088 xref: FMA:15935 xref: MA:0001695 xref: NCIT:C48940 xref: UMLS:C1706967 {source="ncithesaurus:Bladder_Lamina_Propria"} is_a: UBERON:0000030 ! lamina propria intersection_of: UBERON:0000030 ! lamina propria intersection_of: BFO:0000050 UBERON:0001255 ! part of urinary bladder relationship: BFO:0000050 UBERON:0001259 ! part of mucosa of urinary bladder property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001262 name: wall of intestine def: "An anatomical wall that is part of a intestine [Automatically generated definition]." [OBOL:automatic] synonym: "anatomical wall of bowel" EXACT [OBOL:automatic] synonym: "anatomical wall of intestine" EXACT [OBOL:automatic] synonym: "bowel anatomical wall" EXACT [OBOL:automatic] synonym: "bowel wall" EXACT [OBOL:automatic] synonym: "bowel wall" RELATED [MA:0001525] synonym: "intestinal wall" EXACT [] synonym: "intestine anatomical wall" EXACT [OBOL:automatic] synonym: "intestine wall" EXACT [] synonym: "wall of bowel" EXACT [OBOL:automatic] xref: BTO:0000647 xref: EMAPA:35444 xref: FMA:15949 xref: MA:0001525 xref: MA:0002693 xref: NCIT:C49478 xref: UMLS:C1708548 {source="ncithesaurus:Intestinal_Wall_Tissue"} is_a: UBERON:0000328 ! gut wall intersection_of: UBERON:0000060 ! anatomical wall intersection_of: BFO:0000050 UBERON:0000160 ! part of intestine relationship: BFO:0000050 UBERON:0000160 ! part of intestine property_value: IAO:0000116 "we place two MA classes here due to the official ncit2ma mapping to intestinal wall tissue; not clear how bowel and intestine are different" xsd:string property_value: skos:prefLabel "wall of intestine" xsd:string [Term] id: UBERON:0001263 name: pancreatic acinus def: "The secretory units of the exocrine pancreas, where fluid containing digestive enzymes is produced; consists of a group of secretory cells surrounding a luminal space that connects to the pancreatic duct." [MP:0009145] subset: human_reference_atlas subset: pheno_slim synonym: "acinus pancreaticus" EXACT OMO:0003011 [FMA:16011] synonym: "pancreas acinus" EXACT [] synonym: "pancreatic acinar" RELATED [] synonym: "pancreatic acini" RELATED OMO:0003004 [] xref: EMAPA:35651 xref: FMA:16011 xref: MA:0002417 xref: NCIT:C49268 xref: SCTID:247604006 xref: UMLS:C0227578 {source="ncithesaurus:Pancreatic_Acinus"} is_a: BFO:0000002 is_a: UBERON:0013232 ! serous acinus intersection_of: UBERON:0009842 ! glandular acinus intersection_of: BFO:0000050 UBERON:0000017 ! part of exocrine pancreas relationship: BFO:0000050 UBERON:0007324 {source="FMA"} ! part of pancreatic lobule relationship: RO:0002433 UBERON:0000017 ! contributes to morphology of exocrine pancreas relationship: RO:0002473 CL:0002064 ! composed primarily of pancreatic acinar cell property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "pancreatic acinus" xsd:string [Term] id: UBERON:0001264 name: pancreas def: "An endoderm derived structure that produces precursors of digestive enzymes and blood glucose regulating hormones[GO]." [GO:0031016] subset: efo_slim subset: human_reference_atlas subset: major_organ subset: organ_slim subset: pheno_slim subset: uberon_slim subset: vertebrate_core xref: AAO:0010112 xref: BTO:0000988 xref: CALOHA:TS-0736 xref: EFO:0000855 xref: EHDAA2:0001367 xref: EHDAA:6893 xref: EMAPA:17503 xref: EV:0100092 xref: FMA:7198 xref: GAID:334 xref: galen:Pancreas xref: MA:0000120 xref: MAT:0000075 xref: MESH:D010179 xref: MIAA:0000075 xref: NCIT:C12393 xref: SCTID:181277001 xref: TAO:0000140 xref: UMLS:C0030274 {source="ncithesaurus:Pancreas"} xref: VHOG:0000050 xref: Wikipedia:Pancreas xref: XAO:0000136 xref: ZFA:0000140 is_a: BFO:0000002 is_a: UBERON:0002075 ! viscus relationship: BFO:0000051 UBERON:0000016 ! has part endocrine pancreas relationship: RO:0002254 UBERON:0003924 {source="Wikipedia"} ! has developmental contribution from ventral pancreatic bud property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/pancreas-female/v1.3/assets/3d-vh-f-pancreas.glb" xsd:anyURI property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/pancreas-male/v1.3/assets/3d-vh-m-pancreas.glb" xsd:anyURI property_value: foaf:depiction "https://upload.wikimedia.org/wikipedia/commons/7/7e/Blausen_0699_PancreasAnatomy2.png" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "pancreas" xsd:string [Term] id: UBERON:0001265 name: trabecula of spleen def: "A trabecula that is part of a spleen." [OBOL:automatic] subset: human_reference_atlas synonym: "spleen trabeculum" EXACT [] synonym: "splenic trabecula" EXACT [] synonym: "trabeculae of spleen" EXACT OMO:0003004 [] xref: EMAPA:35808 xref: FMA:16027 xref: MA:0000758 xref: NCIT:C33607 xref: SCTID:61987002 xref: UMLS:C0229688 {source="ncithesaurus:Splenic_Trabecula"} xref: Wikipedia:Trabeculae_of_spleen is_a: UBERON:0000440 ! trabecula intersection_of: UBERON:0000440 ! trabecula intersection_of: BFO:0000050 UBERON:0002106 ! part of spleen relationship: BFO:0000050 UBERON:1000024 {source="FMA"} ! part of parenchyma of spleen property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "trabecula of spleen" xsd:string [Term] id: UBERON:0001266 name: splenic cord def: "A structure found in the red pulp of the spleen between the sinusoids, consisting of fibrils and connective tissue cells with a large population of monocytes and macrophages. These cords contain half of the human body's monocytes as a reserve so that after tissue injury these monocytes can move in and aid locally sourced monocytes in wound healing. Erythrocytes pass through the cords of Billroth before entering the sinusoids. The passage into the sinusoids may be seen as a bottleneck, where erythrocytes need to be flexible in order to pass through. In disorders of erythrocyte shape and/or flexibility, such as hereditary spherocytosis, erythrocytes fail to pass through and get phagocytosed, causing extravascular hemolysis." [Wikipedia:Cords_of_Billroth] subset: human_reference_atlas synonym: "cord of Billroth" EXACT [Wikipedia:Cords_of_Billroth] synonym: "cord of Bilroth" EXACT [FMA:16031] xref: EMAPA:37752 {source="MA:th"} xref: FMA:16031 xref: MA:0002671 xref: NCIT:C33599 xref: UMLS:C0735011 {source="ncithesaurus:Splenic_Cord"} xref: Wikipedia:Cords_of_Billroth is_a: UBERON:0000064 ! organ part relationship: BFO:0000050 UBERON:0001250 {source="MA"} ! part of red pulp of spleen property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001268 name: peritoneal fluid def: "Transudate contained in the peritoneal cavity." [FMA:16515] subset: pheno_slim subset: uberon_slim xref: BTO:0001031 xref: EMAPA:35683 xref: FMA:16515 xref: MA:0002531 xref: MESH:D001202 {sssom:mapping_justification="https://w3id.org/semapv/vocab/LexicalMatching"} xref: ncithesaurus:Peritoneal_Fluid xref: Wikipedia:Peritoneal_fluid is_a: UBERON:0007779 ! transudate is_a: UBERON:0007794 {source="FMA"} ! secretion of serous gland is_a: UBERON:0036217 ! coelomic fluid intersection_of: UBERON:0007779 ! transudate intersection_of: RO:0001025 UBERON:0001179 ! located in peritoneal cavity relationship: RO:0001025 UBERON:0001179 ! located in peritoneal cavity property_value: skos:prefLabel "peritoneal fluid" xsd:string [Term] id: UBERON:0001271 name: pelvic girdle region def: "The organism subdivision that includes the pelvic girdle skeleton and associated soft tissue. Note that this includes both the skeletal elements and associated tissues (integument, muscle, etc). Examples: There are only two instances in an organism, right and left pelvic girdle regions." [DOI:10.1002/dvdy.22617, FMA:16581, FMA:23217, https://groups.google.com/d/topic/obo-anatomy/h4R4xKmINrw/discussion, https://orcid.org/0000-0002-6601-2165, UBERONREF:0000003] subset: uberon_slim subset: vertebrate_core synonym: "girdle - pelvic" RELATED [] synonym: "pelvic girdle" RELATED INCONSISTENT [] xref: EMAPA:37862 {source="MA:th"} xref: FMA:16581 xref: NCIT:C33291 xref: SCTID:360010001 xref: UMLS:C0684083 {source="ncithesaurus:Pelvic_Girdle"} xref: VSAO:0000304 is_a: BFO:0000002 is_a: UBERON:0007823 ! appendage girdle region is_a: UBERON:0015212 ! lateral structure intersection_of: UBERON:0007823 ! appendage girdle region intersection_of: BFO:0000050 UBERON:0010709 ! part of pelvic complex disjoint_from: UBERON:0007832 ! pelvic girdle skeleton relationship: BFO:0000050 UBERON:0010709 ! part of pelvic complex relationship: BSPO:0000126 UBERON:0002355 ! pelvic region of trunk relationship: RO:0002551 UBERON:0007832 ! has skeleton pelvic girdle skeleton [Term] id: UBERON:0001272 name: innominate bone def: "A fused bone consisting of the ilium, ischium and pubis. Together with the sacrum and coccyx, it comprises the pelvis. [WP,modified]." [https://github.com/obophenotype/uberon/issues/290, https://orcid.org/0000-0002-6601-2165, Wikipedia:Hip_bone] subset: human_reference_atlas subset: uberon_slim synonym: "basipterygium" RELATED [] synonym: "bone of pelvic girdle" BROAD [FMA:16585] synonym: "coxal bone" EXACT [FMA:16585] synonym: "hip bone" EXACT [FMA:16585] synonym: "innominate" BROAD [] synonym: "innominate bone" EXACT [FMA:16585] synonym: "os coxa" EXACT OMO:0003011 [] synonym: "os coxae" EXACT OMO:0003011 [FMA:16585, FMA:TA] synonym: "os innominatum" RELATED OMO:0003011 [Wikipedia:Hip_bone] synonym: "pelvic bone" EXACT [FMA:16585] xref: FMA:16585 xref: GAID:205 xref: SCTID:361776002 xref: Wikipedia:Hip_bone is_a: UBERON:0007830 ! pelvic girdle bone/zone is_a: UBERON:0010428 {source="FMA"} ! flat bone is_a: UBERON:0015212 ! lateral structure relationship: BFO:0000050 UBERON:0001464 {source="FMA"} ! part of hip relationship: BSPO:0000126 UBERON:0007832 ! pelvic girdle skeleton property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/8/8b/Gray341.png" xsd:anyURI property_value: IAO:0000116 "currently this class is restricted to exclude the teleost bone as the definition mentions ilium, ischium and pubis. In future we may add a grouping class for girdle bones that supports the appendage" xsd:string property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001273 name: ilium def: "Paired endochondral bone that is the dorsal-most of the pelvic bones, offering attachment areas for gluteal muscles on its main surface [PHENOSCAPE:ad]." [https://github.com/obophenotype/uberon/issues/105, https://github.com/obophenotype/uberon/issues/60, PHENOSCAPE:ad] subset: efo_slim subset: pheno_slim subset: uberon_slim synonym: "iliac bone" EXACT [EMAPA:18726] synonym: "ilium bone" EXACT [] synonym: "illium" RELATED [] synonym: "os iliacum" EXACT [] synonym: "os ilii" EXACT [] synonym: "os ilium" EXACT OMO:0003011 [FMA:16589, FMA:TA] xref: AAO:0000772 xref: CALOHA:TS-2200 xref: EFO:0003049 xref: EMAPA:18726 xref: FMA:16589 xref: GAID:207 xref: galen:Ilium xref: MA:0001336 xref: MESH:D007085 xref: NCIT:C32765 xref: SCTID:182029005 xref: UMLS:C0020889 {source="ncithesaurus:Ilium"} xref: Wikipedia:Ilium_(bone) is_a: UBERON:0002513 ! endochondral bone is_a: UBERON:0007830 ! pelvic girdle bone/zone is_a: UBERON:0015054 ! iliac endochondral element is_a: UBERON:0015212 ! lateral structure intersection_of: UBERON:0015054 ! iliac endochondral element intersection_of: RO:0002473 UBERON:0002481 ! composed primarily of bone tissue relationship: BFO:0000050 UBERON:0001272 {source="FMA"} ! part of innominate bone relationship: BSPO:0000126 UBERON:0007832 ! pelvic girdle skeleton relationship: RO:0002202 UBERON:0010714 {source="cjm"} ! develops from iliac cartilage element relationship: RO:0002433 UBERON:0007830 ! contributes to morphology of pelvic girdle bone/zone property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/pelvis-female/v1.3/assets/3d-vh-f-pelvis.glb" xsd:anyURI property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/pelvis-male/v1.3/assets/3d-vh-m-pelvis.glb" xsd:anyURI property_value: RO:0002161 NCBITaxon:32443 {source="Wikipedia"} property_value: terms:contributor https://orcid.org/0000-0001-9114-8737 property_value: terms:contributor https://orcid.org/0000-0002-6601-2165 [Term] id: UBERON:0001274 name: ischium def: "Endochondral bone that is paired, forming the posterior part of the pelvis, articulating with the pubis and ilium." [VSAO:0005006, VSAO:NI, Wikipedia:Ischium] subset: pheno_slim subset: uberon_slim synonym: "ischial bone" EXACT [EMAPA:18727] synonym: "ischium bone" EXACT [] synonym: "os ischii" RELATED OMO:0003011 [AAO:0000860, Wikipedia:Ischium] xref: AAO:0000860 xref: EMAPA:18727 xref: FMA:16592 xref: GAID:208 xref: galen:Ischium xref: MA:0001337 xref: MESH:D007512 xref: NCIT:C32884 xref: SCTID:182025004 xref: UMLS:C0022122 {source="ncithesaurus:Ischium"} xref: VSAO:0005006 xref: Wikipedia:Ischium is_a: UBERON:0002513 {source="VSAO"} ! endochondral bone is_a: UBERON:0007830 {source="MA"} ! pelvic girdle bone/zone is_a: UBERON:0008202 {source="MA"} ! bone of hip region is_a: UBERON:0015056 ! ischial endochondral element is_a: UBERON:0015212 ! lateral structure intersection_of: UBERON:0015056 ! ischial endochondral element intersection_of: RO:0002473 UBERON:0002481 ! composed primarily of bone tissue relationship: BFO:0000050 UBERON:0001272 ! part of innominate bone relationship: BSPO:0000126 UBERON:0007832 ! pelvic girdle skeleton relationship: RO:0002202 UBERON:0006254 {source="cjm"} ! develops from ischial cartilage element relationship: RO:0002433 UBERON:0007830 ! contributes to morphology of pelvic girdle bone/zone property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/2/29/Illu_pelvic_girdle.jpg" xsd:anyURI property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/pelvis-female/v1.3/assets/3d-vh-f-pelvis.glb" xsd:anyURI property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/pelvis-male/v1.3/assets/3d-vh-m-pelvis.glb" xsd:anyURI [Term] id: UBERON:0001276 name: epithelium of stomach def: "The epithelial layer of the stomach ." [MP:0000471] subset: pheno_slim synonym: "epithelial tissue of stomach" EXACT [OBOL:automatic] synonym: "epithelial tissue of ventriculus" EXACT [OBOL:automatic] synonym: "epithelium of ventriculus" EXACT [OBOL:automatic] synonym: "gastric epithelium" RELATED [BTO:0000500] synonym: "stomach epithelial tissue" EXACT [OBOL:automatic] synonym: "stomach epithelium" EXACT [OBOL:automatic] synonym: "ventriculus epithelial tissue" EXACT [OBOL:automatic] synonym: "ventriculus epithelium" EXACT [OBOL:automatic] xref: BTO:0000500 xref: CALOHA:TS-2068 xref: EHDAA2:0001918 xref: EMAPA:17023 xref: FMA:17091 xref: MA:0001610 xref: SCTID:64977002 xref: VHOG:0001433 is_a: UBERON:0000485 ! simple columnar epithelium is_a: UBERON:0003350 ! epithelium of mucosa is_a: UBERON:0004808 ! gastrointestinal system epithelium is_a: UBERON:0015833 ! foregut epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: BFO:0000050 UBERON:0000945 ! part of stomach relationship: BFO:0000050 UBERON:0001199 ! part of mucosa of stomach relationship: RO:0002433 UBERON:0001199 ! contributes to morphology of mucosa of stomach property_value: skos:prefLabel "epithelium of stomach" xsd:string [Term] id: UBERON:0001277 name: intestinal epithelium def: "Epithelial layer that lines the intestine." [UBERON:cjm] subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "bowel epithelial tissue" EXACT [OBOL:automatic] synonym: "bowel epithelium" EXACT [OBOL:automatic] synonym: "epithelial tissue of bowel" EXACT [OBOL:automatic] synonym: "epithelial tissue of intestine" EXACT [OBOL:automatic] synonym: "epithelium of bowel" EXACT [OBOL:automatic] synonym: "epithelium of intestine" EXACT [OBOL:automatic] synonym: "intestine epithelial tissue" EXACT [OBOL:automatic] synonym: "intestine epithelium" RELATED [] synonym: "villous epithelium" NARROW [ZFA:0005124] xref: BTO:0000781 xref: EMAPA:32873 xref: FMA:17229 xref: MA:0001536 xref: NCIT:C49240 xref: SCTID:266135004 xref: TAO:0005124 xref: UMLS:C0226890 {source="ncithesaurus:Intestinal_Epithelium"} xref: Wikipedia:Intestinal_epithelium xref: ZFA:0005124 is_a: UBERON:0000485 ! simple columnar epithelium is_a: UBERON:0003350 ! epithelium of mucosa is_a: UBERON:0003929 ! digestive tract epithelium is_a: UBERON:0004808 ! gastrointestinal system epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: BFO:0000050 UBERON:0000160 ! part of intestine relationship: BFO:0000050 UBERON:0001242 ! part of intestinal mucosa relationship: RO:0002433 UBERON:0000160 ! contributes to morphology of intestine property_value: skos:prefLabel "intestinal epithelium" xsd:string [Term] id: UBERON:0001278 name: epithelium of large intestine def: "An epithelium that is part of a large intestine [Automatically generated definition]." [OBOL:automatic] synonym: "epithelial tissue of large intestine" EXACT [OBOL:automatic] synonym: "large intestinal epithelium" EXACT [] synonym: "large intestine epithelial tissue" EXACT [OBOL:automatic] synonym: "large intestine epithelium" EXACT [] xref: CALOHA:TS-2105 xref: EMAPA:35466 xref: FMA:17301 xref: MA:0001545 is_a: UBERON:0001277 ! intestinal epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: BFO:0000050 UBERON:0000059 ! part of large intestine relationship: BFO:0000050 UBERON:0001207 ! part of mucosa of large intestine property_value: skos:prefLabel "epithelium of large intestine" xsd:string [Term] id: UBERON:0001279 name: portal triad def: "A multi-organ-part structure that consists of three vessels of the portal lobule including the bile duct, a terminal branch of the hepatic artery and portal vein, and may also include a lymphatic vessel." [http://orcid.org/0000-0002-6601-2165, ISBN:0-683-40008-8, MGI:csmith, MP:0008993] subset: human_reference_atlas subset: pheno_slim subset: uberon_slim synonym: "trias hepatica" EXACT [] synonym: "trias hepatica" RELATED OMO:0003011 [Wikipedia:Portal_triad] xref: FMA:17523 xref: MA:0002499 xref: NCIT:C33342 xref: SCTID:362192000 xref: UMLS:C0227514 {source="ncithesaurus:Portal_Triad"} xref: Wikipedia:Portal_triad is_a: BFO:0000002 is_a: UBERON:0034921 ! multi organ part structure relationship: BFO:0000050 UBERON:0001172 ! part of hepatic acinus relationship: BFO:0000051 UBERON:0001193 ! has part hepatic artery relationship: BFO:0000051 UBERON:0002017 ! has part portal vein relationship: BFO:0000051 UBERON:0003704 ! has part intrahepatic bile duct relationship: RO:0002433 UBERON:0001171 ! contributes to morphology of portal lobule property_value: foaf:depiction "https://upload.wikimedia.org/wikipedia/commons/6/62/Portal_triad.JPG" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "portal triad" xsd:string [Term] id: UBERON:0001280 name: liver parenchyma def: "The functional units of the liver including the lobules." [MP:0008986] subset: pheno_slim synonym: "hepatic parenchyma" EXACT [FMA:17540] synonym: "hepatic parenchyme" RELATED [VHOG:0000539] synonym: "liver parenchyme" EXACT [XAO:0000454] synonym: "parenchyma of liver" EXACT [FMA:17540] xref: AAO:0010405 xref: EHDAA2:0001004 xref: EHDAA:2201 xref: EMAPA:17203 xref: FMA:17540 xref: MA:0000366 xref: NCIT:C32735 xref: SCTID:363535004 xref: UMLS:C0736268 xref: VHOG:0000539 xref: XAO:0000454 is_a: UBERON:0000353 ! parenchyma is_a: UBERON:0004119 ! endoderm-derived structure intersection_of: UBERON:0000353 ! parenchyma intersection_of: BFO:0000050 UBERON:0002107 ! part of liver relationship: BFO:0000050 UBERON:0002107 ! part of liver relationship: RO:0002202 UBERON:0008835 {source="XAO"} ! develops from hepatic diverticulum relationship: RO:0002433 UBERON:0002107 ! contributes to morphology of liver property_value: skos:prefLabel "liver parenchyma" xsd:string [Term] id: UBERON:0001281 name: hepatic sinusoid def: "Wide thin-walled blood vessels in the liver. In mammals they have neither veinous or arterial markers." [Wikipedia:Hepatic_sinusoid, ZFIN:curator] subset: human_reference_atlas subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "hepatic sinusoids" RELATED [] synonym: "liver hepatic sinusoids" EXACT [EHDAA2:0000999] synonym: "liver sinusoid" EXACT [] synonym: "liver sinusoidal blood vessel" EXACT [OBOL:automatic] synonym: "sinusoid of liver" EXACT [OBOL:automatic] synonym: "sinusoidal blood vessel of liver" EXACT [OBOL:automatic] synonym: "vas capillare sinusoideum" EXACT [] synonym: "vas sinusoideum" EXACT OMO:0003011 [Wikipedia:Hepatic_sinusoid] xref: EHDAA2:0000999 xref: EMAPA:17365 xref: FMA:17543 xref: MA:0000367 xref: NCIT:C32733 xref: SCTID:67435004 xref: TAO:0005091 xref: UMLS:C0227523 {source="ncithesaurus:Hepatic_Sinusoid"} xref: VHOG:0000708 xref: Wikipedia:Hepatic_sinusoid xref: ZFA:0005091 is_a: UBERON:0003909 ! sinusoid is_a: UBERON:0015796 ! liver blood vessel intersection_of: UBERON:0003909 ! sinusoid intersection_of: BFO:0000050 UBERON:0002107 ! part of liver relationship: BFO:0000050 UBERON:0004647 ! part of liver lobule relationship: BFO:0000050 UBERON:0006877 {source="https://github.com/obophenotype/uberon/wiki/Inferring-part-of-relationships"} ! part of vasculature of liver relationship: RO:0002170 UBERON:0006841 ! connected to central vein of liver relationship: RO:0002226 UBERON:0001113 ! develops in lobe of liver relationship: RO:0002433 UBERON:0004647 ! contributes to morphology of liver lobule property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001282 name: intralobular bile duct def: "The tubules located between the bile canaliculi and interlobular bile ducts near the outer edge of a classic liver lobule." [MGI:csmith, MP:0009499] subset: human_reference_atlas subset: pheno_slim subset: uberon_slim synonym: "canal of Hering" RELATED [] synonym: "canal of Herring" EXACT [FMA:17545] synonym: "canals of Hering" RELATED OMO:0003004 [Wikipedia:Canals_of_Hering] synonym: "cholangiole" EXACT [FMA:17545] synonym: "duct of Herring" RELATED [Wikipedia:Canals_of_Hering] synonym: "ductus interlobularis bilifer" EXACT OMO:0003011 [FMA:17545, FMA:TA] synonym: "intrahepatic bile ductule" RELATED [Wikipedia:Canals_of_Hering] xref: FMA:17545 xref: MA:0002669 xref: NCIT:C32255 xref: SCTID:227002 xref: SCTID:269922006 xref: UMLS:C0227517 {source="ncithesaurus:Canal_of_Hering"} xref: Wikipedia:Canals_of_Hering is_a: UBERON:0003704 {source="FMA"} ! intrahepatic bile duct is_a: UBERON:0014716 ! interlobular duct relationship: BFO:0000050 UBERON:0001172 {source="FMA"} ! part of hepatic acinus relationship: BFO:0000050 UBERON:0004647 {source="FMA"} ! part of liver lobule relationship: BFO:0000051 CL:0000182 ! has part hepatocyte relationship: BFO:0000051 CL:1000488 ! has part cholangiocyte relationship: RO:0002433 UBERON:0004647 ! contributes to morphology of liver lobule property_value: IAO:0000116 "Note that this is part of the intrahepatic bile duct in MA, as this class is more alike the tree in FMA. Note also that SCT has canal of Hering and Entire IBduct as the only sibling terms under 'Structure of intralobular bile duct' (i.e. the CoH is the only part of the entire IBduct)" xsd:string property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "intralobular bile duct" xsd:string [Term] id: UBERON:0001285 name: nephron def: "The basic functional unit of the kidney. its chief function is to regulate the concentration of water and soluble substances like sodium salts by filtering the blood, reabsorbing what is needed and excreting the rest as urine. A nephron eliminates wastes from the body, regulates blood volume and blood pressure, controls levels of electrolytes and metabolites, and regulates blood pH. Its functions are vital to life and are regulated by the endocrine system by hormones such as antidiuretic hormone, aldosterone, and parathyroid hormone.[WP]." [PMID:9268568, Wikipedia:Nephron] subset: human_reference_atlas subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "mature nephron" NARROW [EMAPA:28491] synonym: "nephroneum" RELATED OMO:0003011 [Wikipedia:Nephron] synonym: "tubulus renalis" RELATED OMO:0003011 [Wikipedia:Nephron] xref: BTO:0000924 xref: CALOHA:TS-1312 xref: EMAPA:28491 xref: EMAPA:35592 xref: EV:0100384 xref: FMA:17640 xref: GAID:428 xref: MA:0000375 xref: MESH:D009399 xref: NCIT:C13048 xref: SCTID:361337001 xref: TAO:0002153 xref: UMLS:C0027713 {source="ncithesaurus:Nephron"} xref: Wikipedia:Nephron xref: ZFA:0005282 is_a: BFO:0000002 is_a: UBERON:0000064 ! organ part relationship: BFO:0000050 UBERON:0007684 {source="FMA"} ! part of uriniferous tubule relationship: RO:0002433 UBERON:0002113 ! contributes to morphology of kidney relationship: RO:0002495 UBERON:0010532 {source="Bgee:AN"} ! immediate transformation of primitive nephron property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/0/02/Gray1128.png" xsd:anyURI property_value: IAO:0000116 "kidney terms require review for cross-vertebrate compatibility and developmental relationships." xsd:string property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001286 name: Bowman's space def: "A narrow chalice-shaped cavity between the glomerular and capsular epithelium of the glomerular capsule of the kidney[TFD]. Between the visceral and parietal layers, into which the filtrate enters after passing through the podocytes' filtration slits[WP]. luminal region between the glomerular capsule visceral and parietal layers, into which filtrate enters after passing through the filtration barrier from the glomerular capillaries[MP]." [http://medical-dictionary.thefreedictionary.com/bowman's+space, MP:0011499, Wikipedia:Bowman's_space] subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "Bowman's space" EXACT [] synonym: "Bowmanb%s space" RELATED [TAO:0005312] synonym: "capsular space" EXACT [http://medical-dictionary.thefreedictionary.com/bowman's+space] synonym: "glomerular capsule space" EXACT [MP:0011499] synonym: "glomerular urinary space" EXACT [MP:0011499] synonym: "inter-glomerular space" EXACT [ZFA:0005283, ZFA:0005312] synonym: "pronephric capsular space" EXACT [ZFA:0005312] synonym: "renal capsular space" EXACT [ZFA:0005283] synonym: "urinary space" EXACT [] synonym: "urinary space of renal corpuscle" EXACT [EMAPA:28263] xref: EMAPA:27985 xref: EMAPA:28263 xref: FMA:17676 xref: MA:0001664 xref: NCIT:C33840 xref: SCTID:244284006 xref: TAO:0005283 xref: TAO:0005312 xref: UMLS:C0227643 {source="ncithesaurus:Urinary_Space"} xref: Wikipedia:Bowman's_space xref: ZFA:0005283 xref: ZFA:0005312 is_a: UBERON:0000464 ! anatomical space relationship: BFO:0000050 UBERON:0001230 ! part of glomerular capsule relationship: RO:0002433 UBERON:0001230 ! contributes to morphology of glomerular capsule property_value: IAO:0000116 "TODO - fix ZFA" xsd:string [Term] id: UBERON:0001287 name: proximal convoluted tubule def: "The proximal convoluted tubule is the most proximal portion of the proximal tubule and extends from the glomerular capsule to the proximal straight tubule." [GO:0072019] subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "1st convoluted tubule" RELATED [] synonym: "first convoluted tubule" RELATED [] synonym: "kidney proximal convoluted tubule" RELATED [EMAPA:28287] synonym: "PCT" RELATED [] synonym: "proximal convoluted renal tubule" EXACT [] synonym: "renal proximal convoluted tubule" RELATED [http://orcid.org/0000-0002-6601-2165] synonym: "tubulus contortus proximalis" EXACT [] synonym: "tubulus contortus proximalis" RELATED OMO:0003011 [Wikipedia:Proximal_convoluted_tubule] synonym: "tubulus convolutus proximalis" RELATED OMO:0003011 [] xref: CALOHA:TS-2198 xref: EMAPA:28287 xref: EV:0100388 xref: FMA:17693 xref: MA:0001669 xref: NCIT:C33417 xref: SCTID:362220008 xref: TAO:0005290 xref: UMLS:C1514580 {source="ncithesaurus:Proximal_Convoluted_Tube"} xref: Wikipedia:Proximal_convoluted_tubule xref: ZFA:0005290 is_a: UBERON:0006534 {source="MA"} ! renal convoluted tubule is_a: UBERON:0006853 ! renal cortex tubule is_a: UBERON:0012275 ! meso-epithelium relationship: BFO:0000050 UBERON:0004134 ! part of proximal tubule relationship: RO:0002150 UBERON:0001230 {source="GO"} ! continuous with glomerular capsule relationship: RO:0002150 UBERON:0001290 ! continuous with proximal straight tubule relationship: RO:0002202 UBERON:0003220 {source="Wikipedia"} ! develops from metanephric mesenchyme relationship: RO:0002433 UBERON:0001231 ! contributes to morphology of nephron tubule property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/0/02/Gray1128.png" xsd:anyURI [Term] id: UBERON:0001288 name: loop of Henle def: "The section of the renal tubule in the kidney medulla with a hairpin bend; consists of a descending limb and an ascending limb, and is situated between the proximal convoluted tubule to the distal convoluted tubule; it functions to reabsorb water and ions from the urine." [MGI:csmith, MP:0004755] subset: pheno_slim subset: uberon_slim synonym: "ansa nephroni" EXACT OMO:0003011 [Wikipedia:Loop_of_Henle] synonym: "Henle loop" EXACT [] synonym: "Henle's loop" EXACT [] xref: BTO:0004608 xref: EMAPA:19280 xref: EV:0100390 xref: FMA:17698 xref: GAID:437 xref: MA:0001675 xref: MESH:D008138 xref: NCIT:C33006 xref: SCTID:361335009 xref: UMLS:C0023986 {source="ncithesaurus:Loop_of_Henle"} xref: VHOG:0001270 xref: Wikipedia:Loop_of_Henle is_a: UBERON:0007685 ! region of nephron tubule intersection_of: UBERON:0007685 ! region of nephron tubule intersection_of: RO:0002150 UBERON:0001287 ! continuous with proximal convoluted tubule intersection_of: RO:0002150 UBERON:0001292 ! continuous with distal convoluted tubule relationship: RO:0002150 UBERON:0001287 ! continuous with proximal convoluted tubule relationship: RO:0002150 UBERON:0001292 ! continuous with distal convoluted tubule relationship: RO:0002433 UBERON:0001231 ! contributes to morphology of nephron tubule property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/0/02/Gray1128.png" xsd:anyURI property_value: IAO:0000116 "the definitions of some kidney parts (e.g. proximal straight tubule) refer to Henle's loop, even in species where this may not be present. Requires review." xsd:string property_value: RO:0002175 NCBITaxon:8782 [Term] id: UBERON:0001289 name: descending limb of loop of Henle def: "The portion of the renal tubule that constitutes the proximal part of the loop of Henle, has low permeability to ions and urea, and is highly permeable to water; it consists of an initial short thick segment lined by low simple cuboidal epithelium and a long thin segment lined by simple squamous epithelium; however, this distinction is not as important physiologically as in the ascending limb, so often the two are treated as one structure." [MGI:anna, MP:0011341] subset: human_reference_atlas subset: pheno_slim subset: uberon_slim synonym: "descending limb" BROAD [] synonym: "descending limb of Henle's loop" EXACT [] synonym: "loop of Henle descending limb" EXACT [] xref: EMAPA:35511 xref: FMA:17705 xref: MA:0001679 xref: NCIT:C32456 xref: SCTID:245350001 xref: UMLS:C0227657 {source="ncithesaurus:Descending_Limb_of_the_Henle_s_Loop"} xref: Wikipedia:Descending_limb_of_loop_of_henle is_a: UBERON:0007685 {source="FMA"} ! region of nephron tubule relationship: BFO:0000050 UBERON:0001288 {source="FMA"} ! part of loop of Henle relationship: RO:0002433 UBERON:0001288 ! contributes to morphology of loop of Henle property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/0/02/Gray1128.png" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001290 name: proximal straight tubule def: "The proximal straight tubule is the part of the descending limb that extends from the proximal convoluted tubule to the descending thin tubule." [GO:0072020] subset: human_reference_atlas subset: uberon_slim subset: vertebrate_core synonym: "pars recta" RELATED [] synonym: "pars recta tubuli renalis" RELATED [BTO:0000055] synonym: "proximal tubule segment 3" RELATED [MA:0002614] synonym: "S3" EXACT [GO:0072020] synonym: "segment 3 of proximal tubule" RELATED [EMAPA:29661] synonym: "thick descending limb of proximal tubule" EXACT [] synonym: "tubulus rectus proximalis" EXACT [] xref: BTO:0000055 xref: EMAPA:29661 xref: EMAPA:29669 xref: FMA:17716 xref: MA:0002614 xref: TAO:0005291 xref: Wikipedia:Proximal_straight_tubule xref: ZFA:0005291 is_a: UBERON:0006853 ! renal cortex tubule is_a: UBERON:0009035 {source="MA"} ! renal straight tubule relationship: BFO:0000050 UBERON:0001289 {source="MA"} ! part of descending limb of loop of Henle relationship: BFO:0000050 UBERON:0004134 ! part of proximal tubule relationship: RO:0002131 UBERON:0006542 {source="MA"} ! overlaps outer medulla outer stripe loop of Henle relationship: RO:0002150 UBERON:0001287 ! continuous with proximal convoluted tubule relationship: RO:0002150 UBERON:0005096 ! continuous with descending thin limb property_value: IAO:0000116 "TODO - is S3 exactly coincident with PST? todo - ensure relationships work across species (loop of Henle)" xsd:string property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001291 name: thick ascending limb of loop of Henle def: "The distal sub-portion of the ascending loop of Henle which is lined by simple cuboidal epithelium and enters the renal cortex to empty a hypotonic filtrate into the distal convoluted tubule." [MGI:anna, MP:0011344] subset: human_reference_atlas subset: pheno_slim subset: uberon_slim synonym: "ascending thick limb" EXACT [] synonym: "distal straight tubule" EXACT [MA:0001677] synonym: "loop of Henle ascending limb thick segment" EXACT [MA:0001677] synonym: "straight portion of distal convoluted renal tubule" EXACT [] synonym: "straight portion of distal convoluted tubule" EXACT [FMA:17722] synonym: "thick ascending limb" EXACT [] synonym: "thick ascending limb of distal tubule" EXACT [FMA:17722] synonym: "thick ascending limb of Henle's loop" EXACT [] synonym: "tubulus rectus distalis" EXACT [FMA:17722] synonym: "tubulus rectus distalis" RELATED OMO:0003011 [Wikipedia:Thick_ascending_limb_of_loop_of_Henle] xref: EMAPA:28396 xref: EMAPA:29671 xref: EMAPA:35512 xref: FMA:17722 xref: MA:0001677 xref: SCTID:244953001 xref: Wikipedia:Thick_ascending_limb_of_loop_of_Henle is_a: UBERON:0009035 {source="MA"} ! renal straight tubule relationship: BFO:0000050 UBERON:0005164 ! part of ascending limb of loop of Henle relationship: RO:0002433 UBERON:0005164 ! contributes to morphology of ascending limb of loop of Henle property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/0/02/Gray1128.png" xsd:anyURI property_value: IAO:0000116 "TODO - thick/thin check. Also - does the loop of Henle overlap the distal convoluted tubule? FMA divides DCT into straight and convoluted portions" xsd:string property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001292 name: distal convoluted tubule def: "The first segment of the nephron lying just downstream from the loop of Henle, immediately after the macula densa." [GO:0072025] subset: human_reference_atlas subset: pheno_slim subset: uberon_slim synonym: "distal convoluted renal tubule" EXACT [] synonym: "second convoluted tubule" RELATED [] synonym: "tubulus contortus distalis" EXACT [] synonym: "tubulus contortus distalis" RELATED OMO:0003011 [Wikipedia:Distal_convoluted_tubule] synonym: "tubulus convolutus distalis" RELATED OMO:0003011 [] xref: EMAPA:28393 xref: EV:0100389 xref: FMA:17721 xref: MA:0001666 xref: NCIT:C32469 xref: SCTID:361336005 xref: UMLS:C0022676 {source="ncithesaurus:Distal_Convoluted_Tubule"} xref: Wikipedia:Distal_convoluted_tubule is_a: UBERON:0006534 {source="MA"} ! renal convoluted tubule is_a: UBERON:0006853 ! renal cortex tubule is_a: UBERON:0012275 ! meso-epithelium relationship: BFO:0000050 UBERON:0004135 {source="EMAPA", source="GO", source="MA-modified-from-isa"} ! part of distal tubule relationship: RO:0002202 UBERON:0003220 ! develops from metanephric mesenchyme relationship: RO:0002433 UBERON:0001231 ! contributes to morphology of nephron tubule property_value: foaf:depiction "https://upload.wikimedia.org/wikipedia/commons/2/21/Kidney_nephron.png" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001293 name: outer medulla of kidney def: "The renal outer medulla is the region of the kidney that lies between the renal cortex and the renal inner medulla[GO]." [DOI:10.1371/journal.pone.0099864, GOC:mtg_kidney_jan10] subset: pheno_slim synonym: "kidney outer medulla" RELATED [BTO:0001746] synonym: "outer renal medulla" EXACT [] synonym: "outer zone of medulla of kidney" EXACT [] synonym: "outer zone of renal medulla" EXACT [] synonym: "renal outer medulla" EXACT [BTO:0001746] synonym: "set of outer region of renal pyramids" RELATED [FMA:17733] synonym: "zona externa (medullaris renalis)" EXACT OMO:0003011 [FMA:17733, FMA:TA] synonym: "zona externa medullae renalis" EXACT OMO:0003011 [FMA:17733, FMA:TA] xref: BTO:0001746 xref: CALOHA:TS-0508 xref: EMAPA:28310 xref: FMA:17733 xref: MA:0001653 is_a: UBERON:0000064 ! organ part relationship: BFO:0000050 UBERON:0000362 ! part of renal medulla relationship: RO:0002433 UBERON:0000362 ! contributes to morphology of renal medulla [Term] id: UBERON:0001294 name: inner medulla of kidney def: "Innermost region of the mammalian kidney." [GO:0072053] subset: human_reference_atlas subset: pheno_slim synonym: "inner renal medulla" EXACT [] synonym: "inner zone of medulla of kidney" EXACT [] synonym: "inner zone of renal medulla" EXACT [] synonym: "kidney inner medulla" RELATED [BTO:0001745] synonym: "renal inner medulla" EXACT [BTO:0001745] synonym: "set of inner region of renal pyramids" EXACT [] synonym: "zona interna (medullaris renalis)" EXACT OMO:0003011 [FMA:17734, FMA:TA] synonym: "zona interna medullae renalis" EXACT OMO:0003011 [FMA:17734, FMA:TA] xref: BTO:0001745 xref: CALOHA:TS-0506 xref: EMAPA:28349 xref: FMA:17734 xref: MA:0001652 is_a: UBERON:0000064 ! organ part relationship: BFO:0000050 UBERON:0000362 ! part of renal medulla relationship: RO:0002162 NCBITaxon:40674 {source="GO:0072053"} ! in taxon Mammalia relationship: RO:0002433 UBERON:0000362 ! contributes to morphology of renal medulla property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001295 name: endometrium def: "The glandular mucous membrane lining of the uterine cavity that is hormonally responsive during the estrous/menstrual cycle and during pregnancy." [MESH:A05.360.319.679.490, MGI:smb, MP:0004896] subset: efo_slim subset: human_reference_atlas subset: pheno_slim subset: uberon_slim synonym: "tunica mucosa (endometrium)" EXACT [FMA:17742] synonym: "tunica mucosa uteri" EXACT OMO:0003011 [Wikipedia:Endometrium] synonym: "uterine endometrium" EXACT [BTO:0001422] synonym: "uterine mucosa" RELATED [] synonym: "uterine mucous membrane" RELATED [BTO:0001422] xref: BTO:0001422 xref: CALOHA:TS-0276 xref: EFO:0000980 xref: EMAPA:29917 xref: EV:0100115 xref: FMA:17742 xref: GAID:377 xref: MA:0000390 xref: MAT:0000319 xref: MESH:D004717 xref: MIAA:0000319 xref: NCIT:C12313 xref: SCTID:278867007 xref: UMLS:C0014180 {source="ncithesaurus:Endometrium"} xref: VHOG:0001285 xref: Wikipedia:Endometrium is_a: UBERON:0019042 ! reproductive system mucosa intersection_of: UBERON:0000344 ! mucosa intersection_of: BFO:0000050 UBERON:0000995 ! part of uterus relationship: BFO:0000050 UBERON:0000459 {source="FMA"} ! part of uterine wall relationship: RO:0002433 UBERON:0000995 ! contributes to morphology of uterus property_value: foaf:depiction "https://upload.wikimedia.org/wikipedia/commons/6/66/Illu_cervix.jpg" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001296 name: myometrium def: "The smooth muscle coat of the uterus, which forms the main mass of the organ and surrounds and supports the endometrium." [MESH:A02.633.570.500, MGI:brs, MP:0008256] subset: efo_slim subset: pheno_slim subset: uberon_slim synonym: "tunica muscularis" RELATED OMO:0003011 [Wikipedia:Myometrium] synonym: "tunica muscularis (myometrium)" EXACT [] synonym: "uterine myometrium" RELATED [BTO:0000907] synonym: "uterine smooth muscle" RELATED [] xref: BTO:0000907 xref: CALOHA:TS-0652 xref: EFO:0001970 xref: EMAPA:29923 xref: EV:0100116 xref: FMA:17743 xref: GAID:171 xref: MA:0000391 xref: MESH:D009215 xref: NCIT:C12314 xref: SCTID:279879004 xref: UMLS:C0027088 {source="ncithesaurus:Myometrium"} xref: VHOG:0001281 xref: Wikipedia:Myometrium is_a: UBERON:0005156 ! reproductive structure is_a: UBERON:0034933 ! layer of smooth muscle tissue relationship: BFO:0000050 UBERON:0000459 {source="FMA"} ! part of uterine wall relationship: RO:0002219 UBERON:0001297 ! surrounded by serosa of uterus relationship: RO:0002221 UBERON:0001295 ! surrounds endometrium relationship: RO:0002433 UBERON:0000995 ! contributes to morphology of uterus property_value: foaf:depiction "https://upload.wikimedia.org/wikipedia/commons/6/66/Illu_cervix.jpg" xsd:anyURI [Term] id: UBERON:0001297 name: serosa of uterus def: "Outer serosa layer of the uterus." [Wikipedia:Perimetrium] synonym: "perimetrium" EXACT [Wikipedia:Perimetrium] synonym: "serous coat of uterus" EXACT [Wikipedia:Perimetrium] synonym: "serous membrane of uterus" EXACT [OBOL:automatic] synonym: "tunica serosa (perimetrium)" EXACT [] synonym: "tunica serosa uteri" EXACT OMO:0003011 [FMA:17744, FMA:TA] synonym: "uterine serosa" EXACT [] synonym: "uterus serosa" EXACT [] synonym: "uterus serous membrane" EXACT [OBOL:automatic] synonym: "visceral peritoneum of uterus" EXACT [] xref: EMAPA:37792 {source="MA:th"} xref: FMA:17744 xref: MA:0001729 xref: NCIT:C33298 xref: SCTID:253705006 xref: UMLS:C0227824 {source="ncithesaurus:Perimetrium"} xref: Wikipedia:Perimetrium is_a: UBERON:0000042 ! serous membrane is_a: UBERON:0005156 ! reproductive structure intersection_of: UBERON:0000042 ! serous membrane intersection_of: BFO:0000050 UBERON:0000995 ! part of uterus relationship: BFO:0000050 UBERON:0000459 {source="https://github.com/obophenotype/uberon/wiki/Inferring-part-of-relationships"} ! part of uterine wall property_value: foaf:depiction "https://upload.wikimedia.org/wikipedia/commons/6/66/Illu_cervix.jpg" xsd:anyURI property_value: IAO:0000116 "TODO - check for parallel structure with peritoneum" xsd:string [Term] id: UBERON:0001299 name: glans penis def: "The conic expansion of the corpus spongiosum that forms the head of the penis." [MGI:anna, MP:0009102] subset: pheno_slim subset: uberon_slim synonym: "balanus" RELATED [BTO:0003118] synonym: "coronal sulcus" RELATED INCONSISTENT [Wikipedia:Glans_penis] synonym: "glans" BROAD [EV:0100108] xref: BTO:0003118 xref: EMAPA:18988 xref: EV:0100108 xref: FMA:18247 xref: GAID:0000012 xref: MA:0002726 xref: NCIT:C12324 xref: SCTID:263378009 xref: UMLS:C0227948 {source="ncithesaurus:Glans_Penis"} xref: VHOG:0001475 xref: Wikipedia:Glans_penis is_a: UBERON:0035651 ! glans intersection_of: UBERON:0035651 ! glans intersection_of: BFO:0000050 UBERON:0000989 ! part of penis relationship: BFO:0000050 UBERON:0000989 ! part of penis relationship: RO:0002433 UBERON:0000989 ! contributes to morphology of penis relationship: RO:0002495 UBERON:0013239 {source="Bgee:AN"} ! immediate transformation of future glans penis relationship: sexually_homologous_to UBERON:0006653 ! glans clitoris property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/1/13/Anteriorglanspenis.jpg" xsd:anyURI property_value: foaf:depiction "https://upload.wikimedia.org/wikipedia/commons/3/35/Male_anatomy.png" xsd:anyURI [Term] id: UBERON:0001301 name: epididymis def: "The elongated structure connected to the posterior surface of the testis that transports, stores, and matures spermatozoa between testis and vas deferens." [MGI:pvb, MP:0002631] subset: efo_slim subset: pheno_slim subset: uberon_slim xref: BTO:0000408 xref: CALOHA:TS-0285 xref: EFO:0000982 xref: EMAPA:19290 xref: EV:0100103 xref: FMA:18255 xref: GAID:397 xref: galen:Epididymis xref: MA:0000397 xref: MAT:0000130 xref: MESH:D004822 xref: MIAA:0000130 xref: NCIT:C12328 xref: SCTID:181432000 xref: UMLS:C0014533 {source="ncithesaurus:Epididymis"} xref: VHOG:0001265 xref: Wikipedia:Epididymis is_a: UBERON:0000025 ! tube is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0005904 ! duct of male reproductive system relationship: BFO:0000050 UBERON:0006947 {source="FMA"} ! part of male genital duct relationship: channel_for CL:0000019 ! sperm relationship: channels_from UBERON:0006946 ! efferent duct relationship: channels_into UBERON:0001000 ! vas deferens relationship: RO:0002202 UBERON:0003074 {source="Wikipedia"} ! develops from mesonephric duct relationship: RO:0002433 UBERON:0004054 ! contributes to morphology of internal male genitalia property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/c/c3/Illu_testis_surface.jpg" xsd:anyURI property_value: IAO:0000116 "Kardong has epididymis in elasmobranch" xsd:string [Term] id: UBERON:0001302 name: right fallopian tube def: "A fallopian tube that is part of a right side of organism [Automatically generated definition]." [OBOL:automatic] synonym: "right oviduct" BROAD [] synonym: "right uterine tube" EXACT [] xref: EMAPA:37369 {source="MA:th"} xref: FMA:18483 xref: MA:0001717 xref: NCIT:C33475 xref: SCTID:280106006 xref: UMLS:C0227900 {source="ncithesaurus:Right_Fallopian_Tube"} is_a: UBERON:0003889 ! fallopian tube intersection_of: UBERON:0003889 ! fallopian tube intersection_of: BSPO:0000121 UBERON:0000468 ! multicellular organism relationship: BSPO:0000121 UBERON:0000468 ! multicellular organism property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/fallopian-tube-female-right/v1.2/assets/3d-vh-f-fallopian-tube-r.glb" xsd:anyURI [Term] id: UBERON:0001303 name: left fallopian tube def: "A fallopian tube that is part of a left side of organism [Automatically generated definition]." [OBOL:automatic] synonym: "left oviduct" BROAD [] synonym: "left uterine tube" EXACT [] xref: EMAPA:37368 {source="MA:th"} xref: FMA:18484 xref: MA:0001716 xref: NCIT:C32959 xref: SCTID:280107002 xref: UMLS:C0227902 {source="ncithesaurus:Left_Fallopian_Tube"} is_a: UBERON:0003889 ! fallopian tube intersection_of: UBERON:0003889 ! fallopian tube intersection_of: BSPO:0000120 UBERON:0000468 ! multicellular organism relationship: BSPO:0000120 UBERON:0000468 ! multicellular organism property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/fallopian-tube-female-left/v1.2/assets/3d-vh-f-fallopian-tube-l.glb" xsd:anyURI [Term] id: UBERON:0001304 name: germinal epithelium of ovary def: "Layer of simple cuboidal cells covering surface of ovary[WP]." [PMID:16923182, Wikipedia:Germinal_epithelium_(female), Wikipedia:Talk\:Germinal_epithelium_(female)] comment: Controversial - see article. Requires expert input. Also check BTO placement synonym: "epithelium superficiale (ovarium)" EXACT [] synonym: "female coelomic epithelium" RELATED [EMAPA:17384] synonym: "germinal epithelium (female)" EXACT [Wikipedia:Germinal_epithelium_(female)] synonym: "ovarian surface epithelium" EXACT [BTO:0004483] synonym: "ovary germinal epithelium" EXACT [] synonym: "ovary surface epithelium" RELATED [EMAPA:17963] synonym: "surface epithelium of ovary" EXACT [] xref: BTO:0004483 xref: EHDAA:8126 xref: EMAPA:17963 xref: FMA:18629 xref: MA:0001711 xref: NCIT:C61518 xref: RETIRED_EHDAA2:0001361 xref: SCTID:258308007 xref: UMLS:C0227875 {source="ncithesaurus:Ovarian_Surface_Epithelium"} xref: VHOG:0000630 xref: Wikipedia:Germinal_epithelium_(female) is_a: UBERON:0000484 ! simple cuboidal epithelium is_a: UBERON:0004911 ! epithelium of female gonad intersection_of: UBERON:0000484 ! simple cuboidal epithelium intersection_of: BFO:0000050 UBERON:0001307 ! part of capsule of ovary relationship: BFO:0000050 UBERON:0001307 ! part of capsule of ovary [Term] id: UBERON:0001305 name: ovarian follicle def: "A spherical aggregation of cells in the ovary that contains a single oocyte[WP,modified]." [http://www.repropedia.org/ovarian-follicle, Wikipedia:Ovarian_follicle] subset: human_reference_atlas subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "egg follicle" RELATED [ZFA:0001110] synonym: "follicle of ovary" EXACT [] synonym: "follicle of ovary viewed macroscopically" EXACT [FMA:18640] synonym: "folliculi ovarici primarii" RELATED OMO:0003011 [Wikipedia:Ovarian_follicle] synonym: "folliculi ovarici vesiculosi" RELATED OMO:0003011 [Wikipedia:Ovarian_follicle] synonym: "ovary follicle" EXACT [MA:0001707] xref: BTO:0000475 xref: CALOHA:TS-0726 xref: EMAPA:35627 xref: FMA:18640 xref: GAID:371 xref: MA:0001707 xref: MAT:0000449 xref: MESH:D006080 xref: NCIT:C33244 xref: SCTID:361111009 xref: TAO:0001110 xref: UMLS:C0018120 {source="ncithesaurus:Ovarian_Follicle"} xref: VHOG:0001536 xref: Wikipedia:Ovarian_follicle xref: ZFA:0001110 is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:8450001 ! egg follicle relationship: BFO:0000051 CL:0000023 ! has part oocyte relationship: BFO:0000051 CL:0002174 ! has part follicular cell of ovary relationship: BFO:0000051 UBERON:0000038 ! has part follicular fluid relationship: RO:0002202 UBERON:0005296 {source="Wikipedia"} ! develops from ovary sex cord property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/c/ca/Human_ovarian_follicle.jpg" xsd:anyURI property_value: foaf:depiction "https://upload.wikimedia.org/wikipedia/commons/e/e6/Primary_follicle-4.JPG" xsd:anyURI property_value: IAO:0000116 "TODO - align subtypes based on staging, which is taxon-specific" xsd:string property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001307 name: capsule of ovary def: "A capsule that surrounds a female gonad." [OBOL:automatic] subset: pheno_slim synonym: "ovarian capsule" EXACT [] synonym: "ovary capsule" EXACT [] xref: EMAPA:35626 xref: FMA:18662 xref: MA:0001706 xref: NCIT:C49265 xref: SCTID:258491008 xref: UMLS:C0227877 {source="ncithesaurus:Ovarian_Capsule"} is_a: UBERON:0003893 ! capsule is_a: UBERON:0005156 ! reproductive structure intersection_of: UBERON:0003893 ! capsule intersection_of: RO:0002007 UBERON:0000992 ! bounding layer of ovary relationship: RO:0002007 UBERON:0000992 ! bounding layer of ovary [Term] id: UBERON:0001308 name: external iliac artery def: "The external iliac artery is a large artery in the pelvic region that carries blood to the lower limb. The external iliac artery is a paired artery, meaning there is one on each side of the body: a right external iliac artery and left external iliac artery. The external iliac artery is accompanied by the external iliac vein, which is located posterior to the artery. [WP,unvetted]." [Wikipedia:External_iliac_artery] subset: human_reference_atlas subset: uberon_slim synonym: "arteria iliaca externa" RELATED OMO:0003011 [Wikipedia:External_iliac_artery] xref: BTO:0004666 xref: EHDAA2:0000463 xref: EHDAA:4337 xref: EMAPA:17614 xref: FMA:18805 xref: galen:ExternalIliacArtery xref: MA:0001973 xref: NCIT:C32558 xref: SCTID:181352000 xref: UMLS:C0226398 {source="ncithesaurus:External_Iliac_Artery"} xref: Wikipedia:External_iliac_artery is_a: UBERON:0005609 {source="MA"} ! iliac artery relationship: BFO:0000050 UBERON:0001191 ! part of common iliac artery property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/3/3e/Gray539.png" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001309 name: internal iliac artery def: "The internal iliac artery (formerly known as the hypogastric artery) is the main artery of the pelvis. [WP,unvetted]." [Wikipedia:Internal_iliac_artery] subset: human_reference_atlas subset: uberon_slim synonym: "arteria iliaca interna" RELATED OMO:0003011 [Wikipedia:Internal_iliac_artery] synonym: "hypogastric artery" RELATED [BTO:0004667] xref: BTO:0004667 xref: EMAPA:17860 xref: FMA:18808 xref: galen:InternalIliacArtery xref: MA:0001974 xref: NCIT:C32845 xref: SCTID:181346001 xref: UMLS:C0226364 {source="ncithesaurus:Internal_Iliac_Artery"} xref: Wikipedia:Internal_iliac_artery is_a: UBERON:0005609 {source="MA"} ! iliac artery relationship: BFO:0000050 UBERON:0001191 ! part of common iliac artery property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/d/d3/Iliac_artery_bifurcation.PNG" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001310 name: umbilical artery def: "The umbilical artery is a paired artery (with one for each half of the body) that is found in the abdominal and pelvic regions. In the fetus, it extends into the umbilical cord. [WP,unvetted]." [https://github.com/obophenotype/uberon/issues/328, Wikipedia:Umbilical_artery] subset: human_reference_atlas subset: pheno_slim subset: uberon_slim synonym: "a. umbilicalis" RELATED OMO:0003011 [Wikipedia:Umbilical_artery] xref: BTO:0000841 xref: CALOHA:TS-1077 xref: EHDAA:1026 xref: EHDAA:410 xref: EMAPA:16331 xref: EMAPA:16372 xref: FMA:18820 xref: GAID:516 xref: MA:0002072 xref: MESH:D014469 xref: NCIT:C33827 xref: RETIRED_EHDAA2:0002106 xref: SCTID:261404000 xref: UMLS:C0041632 {source="ncithesaurus:Umbilical_Artery"} xref: Wikipedia:Umbilical_artery is_a: UBERON:0001637 ! artery is_a: UBERON:0010260 ! umbilical blood vessel property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/e/ee/Gray502.png" xsd:anyURI property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/placenta-full-term-female/v1.1/assets/3d-vh-f-placenta-full-term.glb" xsd:anyURI property_value: IAO:0000116 "todo - compare with EHDAA2. Check embryonic vs extraembryonic, developmental relationships" xsd:string property_value: RO:0002175 NCBITaxon:9606 property_value: seeAlso "https://github.com/obophenotype/uberon/issues/328" xsd:anyURI [Term] id: UBERON:0001311 name: inferior vesical artery def: "An artery that supplies blood to the lower urinary bladder." [http://orcid.org/0000-0002-6601-2165] subset: human_reference_atlas subset: uberon_slim synonym: "arteria vesicali inferior" EXACT OMO:0003011 [Wikipedia:Inferior_vesical_artery] synonym: "arteria vesicalis inferior" EXACT OMO:0003011 [Wikipedia:Inferior_vesical_artery] synonym: "arteria vesicalis inferior" RELATED OMO:0003011 [Wikipedia:Inferior_vesical_artery] xref: EMAPA:37089 {source="MA:th"} xref: FMA:18823 xref: MA:0002079 xref: NCIT:C52685 xref: SCTID:43210002 xref: UMLS:C0226377 {source="ncithesaurus:Inferior_Vesical_Artery"} xref: Wikipedia:Inferior_vesical_artery is_a: UBERON:0009027 ! vesical artery intersection_of: UBERON:0009027 ! vesical artery intersection_of: RO:0020101 UBERON:0006082 ! vessel supplies blood to fundus of urinary bladder relationship: RO:0002252 UBERON:0001309 ! connecting branch of internal iliac artery relationship: RO:0020101 UBERON:0006082 ! vessel supplies blood to fundus of urinary bladder property_value: foaf:depiction "https://upload.wikimedia.org/wikipedia/commons/1/13/Inferiorvesical.png" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001312 name: superior vesical artery def: "An artery that supplies blood to the upper urinary bladder." [http://orcid.org/0000-0002-6601-2165] subset: human_reference_atlas subset: uberon_slim synonym: "arteria vesicali superior" EXACT OMO:0003011 [Wikipedia:Superior_vesical_artery] synonym: "arteria vesicalis superior" EXACT OMO:0003011 [Wikipedia:Superior_vesical_artery] synonym: "arteriae vesicales superiores" RELATED OMO:0003011 [Wikipedia:Superior_vesical_artery] xref: EMAPA:37123 {source="MA:th"} xref: FMA:18839 xref: MA:0002080 xref: NCIT:C52686 xref: SCTID:113268007 xref: UMLS:C0226376 {source="ncithesaurus:Superior_Vesical_Artery"} xref: Wikipedia:Superior_vesical_artery is_a: UBERON:0003468 ! ureteric segment of renal artery is_a: UBERON:0009027 ! vesical artery intersection_of: UBERON:0009027 ! vesical artery intersection_of: RO:0020101 UBERON:0000056 ! vessel supplies blood to ureter relationship: RO:0002252 UBERON:0001310 ! connecting branch of umbilical artery property_value: foaf:depiction "https://upload.wikimedia.org/wikipedia/commons/0/02/Internal_iliac_branches.PNG" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001316 name: external iliac vein def: "A large vein that connects the femoral vein to the common iliac vein. Their origin is at the inferior margin of the inguinal ligaments and they terminate when they join the internal iliac veins (to form the common iliac veins). Both external iliac veins are accompanied along their course by external iliac arteries. [WP,modified]." [Wikipedia:External_iliac_vein] subset: human_reference_atlas subset: uberon_slim synonym: "vena iliaca externa" RELATED OMO:0003011 [Wikipedia:External_iliac_vein] xref: EHDAA2:0000464 xref: EMAPA:37144 {source="MA:th"} xref: FMA:18883 xref: galen:ExternalIliacVein xref: MA:0002144 xref: NCIT:C32560 xref: SCTID:181400000 xref: UMLS:C0226761 {source="ncithesaurus:External_Iliac_Vein"} xref: Wikipedia:External_iliac_vein is_a: UBERON:0005610 {source="MA"} ! iliac vein relationship: RO:0002170 UBERON:0001139 ! connected to common iliac vein relationship: RO:0020102 UBERON:0002103 ! vessel drains blood from hindlimb property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/blood-vasculature-male/v1.3/assets/3d-vh-m-blood-vasculature.glb" xsd:anyURI property_value: foaf:depiction "https://upload.wikimedia.org/wikipedia/commons/6/65/Iliac_veins.gif" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001317 name: internal iliac vein def: "A vein that begins near the upper part of the greater sciatic foramen, passes upward behind and slightly medial to the hypogastric artery and, at the brim of the pelvis, joins with the external iliac to form the common iliac vein. [WP,unvetted]." [Wikipedia:Internal_iliac_vein] subset: human_reference_atlas subset: uberon_slim synonym: "hypogastric vein" RELATED [MA:0002139, Wikipedia:Internal_iliac_vein] synonym: "v. hypogastrica" RELATED OMO:0003011 [Wikipedia:Internal_iliac_vein] synonym: "v. iliaca interna" RELATED OMO:0003011 [Wikipedia:Internal_iliac_vein] xref: EHDAA2:0000874 xref: EMAPA:37148 {source="MA:th"} xref: FMA:18884 xref: galen:InternalIliacVein xref: MA:0002139 xref: MA:0002145 xref: NCIT:C32847 xref: SCTID:181399007 xref: UMLS:C0226764 {source="ncithesaurus:Internal_Iliac_Vein"} xref: VHOG:0000749 xref: Wikipedia:Internal_iliac_vein is_a: UBERON:0005610 {source="MA"} ! iliac vein relationship: RO:0002170 UBERON:0001139 ! connected to common iliac vein relationship: RO:0020102 UBERON:0005179 ! vessel drains blood from pelvic region element property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/c/cb/Internaliliacv.png" xsd:anyURI property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/blood-vasculature-female/v1.3/assets/3d-vh-f-blood-vasculature.glb" xsd:anyURI property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/blood-vasculature-male/v1.3/assets/3d-vh-m-blood-vasculature.glb" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001318 name: inferior vesical vein subset: human_reference_atlas xref: EMAPA:37158 {source="MA:th"} xref: FMA:18890 xref: MA:0002264 is_a: UBERON:0002460 {is_inferred="true", source="MA"} ! vesical vein intersection_of: UBERON:0001638 ! vein intersection_of: RO:0020102 UBERON:0006082 ! vessel drains blood from fundus of urinary bladder relationship: RO:0020102 UBERON:0006082 ! vessel drains blood from fundus of urinary bladder property_value: IAO:0000116 "inferred from artery" xsd:string property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001319 name: vaginal vein def: "One the veins that drains the vaginal venous plexus, into the hypogastric veins. [WP,modified]." [Wikipedia:Vaginal_venous_plexus] subset: human_reference_atlas subset: uberon_slim synonym: "vagina vein" EXACT [OBOL:automatic] synonym: "vein of vagina" EXACT [OBOL:automatic] xref: EMAPA:37796 {source="MA:th"} xref: FMA:18899 xref: MA:0002251 xref: SCTID:424336009 is_a: UBERON:0001638 ! vein is_a: UBERON:0005156 ! reproductive structure intersection_of: UBERON:0001638 ! vein intersection_of: BFO:0000050 UBERON:0000996 ! part of vagina relationship: BFO:0000050 UBERON:0000996 ! part of vagina relationship: RO:0002376 UBERON:0001317 {source="FMA/obol"} ! tributary of internal iliac vein property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/d/d4/Gray589.png" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001322 name: sciatic nerve def: "A large nerve that supplies nearly the whole of the skin of the leg, the muscles of the back of the thigh, and those of the leg and foot. It begins in the lower back and runs through the buttock and down the lower limb." [Wikipedia:Sciatic_nerve] subset: efo_slim subset: human_reference_atlas subset: pheno_slim subset: uberon_slim synonym: "ischiadic nerve" RELATED [Wikipedia:Sciatic_nerve] synonym: "ischiatic nerve" RELATED [Wikipedia:Sciatic_nerve] synonym: "nervus ischiadicus" RELATED OMO:0003011 [BTO:0001221, Wikipedia:Sciatic_nerve] synonym: "nervus sciaticus" RELATED [BTO:0001221] xref: BIRNLEX:1133 xref: BTO:0001221 xref: CALOHA:TS-0899 xref: EFO:0001417 xref: EHDAA2:0001779 xref: EHDAA:5659 xref: EMAPA:18577 xref: FMA:19034 xref: GAID:852 xref: MA:0001172 xref: MESH:D012584 xref: NCIT:C52810 xref: SCTID:181050003 xref: UMLS:C0036394 {source="BIRNLEX:1133", source="ncithesaurus:Sciatic_Nerve"} xref: VHOG:0000894 xref: Wikipedia:Sciatic_nerve is_a: UBERON:0001021 ! nerve relationship: BFO:0000050 UBERON:0001815 ! part of lumbosacral nerve plexus relationship: RO:0002131 UBERON:0000978 ! overlaps leg relationship: RO:0002134 UBERON:0001511 ! innervates skin of leg property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/3/3a/Gray1244.png" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001323 name: tibial nerve def: "The tibial nerve is a branch of the sciatic nerve. The tibial nerve passes through the popliteal fossa to pass below the arch of soleus. In the popliteal fossa the nerve gives off branches to gastrocnemius, popliteus, soleus and plantaris muscles, an articular branch to the knee joint, and a cutaneous branch that will become the sural nerve. The sural nerve is joined by fibres from the common peroneal nerve and runs down the calf to supply the lateral side of the foot. Below the soleus muscle the nerve lies close to the tibia and supplies the tibialis posterior, the flexor digitorum longus and the flexor hallucis longus. The nerve passes into the foot running posterior to the medial malleolus. Here it is bound down by the flexor retinaculum in company with the posterior tibial artery. [WP,unvetted]." [Wikipedia:Tibial_nerve] subset: uberon_slim synonym: "medial popliteal nerve" EXACT [] synonym: "n. tibialis" RELATED OMO:0003011 [Wikipedia:Tibial_nerve] xref: EMAPA:36512 xref: FMA:19035 xref: GAID:854 xref: MA:0001173 xref: MESH:D013979 xref: NCIT:C52809 xref: SCTID:181078002 xref: UMLS:C0040186 {source="ncithesaurus:Tibial_Nerve"} xref: Wikipedia:Tibial_nerve is_a: UBERON:0003431 ! leg nerve relationship: RO:0002380 UBERON:0001322 {source="FMA", source="WP"} ! branching part of sciatic nerve property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/1/1a/Gray828.png" xsd:anyURI [Term] id: UBERON:0001325 name: muscle of pelvis def: "Muscle (organ) which is a part of the pelvis. Examples: levator ani,." [FMA:19086] subset: pheno_slim subset: uberon_slim synonym: "muscle organ of pelvis" EXACT [OBOL:automatic] synonym: "pelvic muscle" EXACT [FMA:19086] synonym: "pelvis muscle" EXACT [] synonym: "pelvis muscle organ" EXACT [OBOL:automatic] xref: EMAPA:37481 {source="MA:th"} xref: FMA:19086 xref: MA:0000534 is_a: UBERON:0003833 {source="MA"} ! abdominal segment muscle is_a: UBERON:0005179 ! pelvic region element intersection_of: UBERON:0014892 {source="FMAdef"} ! skeletal muscle organ, vertebrate intersection_of: BFO:0000050 UBERON:0002355 {source="FMAdef"} ! part of pelvic region of trunk [Term] id: UBERON:0001328 name: lobe of prostate def: "A portion of a prostate that forms a lobe." [https://github.com/obophenotype/uberon/issues/665] synonym: "lobe of prostate gland" EXACT [] synonym: "prostate gland lobe" EXACT [] synonym: "prostatic lobe" EXACT [] xref: BTO:0000548 xref: EMAPA:35712 xref: FMA:19570 xref: MA:0001738 xref: NCIT:C52726 xref: SCTID:279692004 xref: UMLS:C0227970 {source="ncithesaurus:Prostate_Gland_Lobe"} is_a: UBERON:0005156 ! reproductive structure is_a: UBERON:0009912 ! anatomical lobe intersection_of: UBERON:0009912 ! anatomical lobe intersection_of: BFO:0000050 UBERON:0002367 ! part of prostate gland relationship: BFO:0000050 UBERON:0002367 ! part of prostate gland property_value: terms:contributor https://orcid.org/0000-0002-0956-8634 property_value: terms:contributor https://orcid.org/0000-0002-1572-1316 property_value: terms:contributor https://orcid.org/0000-0002-6601-2165 [Term] id: UBERON:0001330 name: pampiniform plexus def: "The pampiniform plexus is a network of many small veins found in the male spermatic cord. It is formed by the union of multiple spermatic veins from the back of the testis and tributaries from the epididymis. The veins of the plexus ascend along the cord in front of the ductus deferens. Below the subcutaneous inguinal ring they unite to form three or four veins, which pass along the inguinal canal, and, entering the abdomen through the abdominal inguinal ring, coalesce to form two veins. These again unite to form a single vein, the testicular vein, which opens on the right side into the inferior vena cava, at an acute angle, and on the left side into the left renal vein, at a right angle. The pampinoform plexus forms the chief mass of the cord. In addition to its function in venous return from the testes, the pampiniform plexus also plays a role in the temperature regulation of the testes. It acts as a heat exchanger, cooling blood in adjacent arteries. An abnormal enlargement of the pampiniform plexus is a medical condition called varicocele. [WP,unvetted]." [Wikipedia:Pampiniform_venous_plexus] subset: human_reference_atlas subset: uberon_slim synonym: "pampiniform venous plexus" EXACT [] synonym: "plexus of veins of fascia of prostate" EXACT [] synonym: "plexus venosus pampiniformis" EXACT OMO:0003011 [FMA:19607, FMA:TA] synonym: "venous plexus of fascia of prostate" EXACT [] synonym: "venous plexus of fascia of prostate gland" EXACT [] xref: EMAPA:37385 {source="MA:th"} xref: FMA:19607 xref: MA:0001866 xref: SCTID:279661001 xref: Wikipedia:Pampiniform_venous_plexus is_a: UBERON:0001593 ! venous plexus relationship: RO:0001025 UBERON:0005352 ! located in spermatic cord relationship: RO:0002170 UBERON:0000442 ! connected to right testicular vein property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/a/af/Gray1147.png" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001331 name: skin of penis def: "A zone of skin that is part of a penis [Automatically generated definition]." [OBOL:automatic] synonym: "penile skin" EXACT [FMA:19638] synonym: "penis skin" EXACT [] synonym: "penis zone of skin" EXACT [OBOL:automatic] synonym: "zone of skin of penis" EXACT [OBOL:automatic] xref: EMAPA:35675 xref: FMA:19638 xref: MA:0002727 xref: SCTID:35900000 is_a: UBERON:0000014 ! zone of skin is_a: UBERON:0005156 ! reproductive structure intersection_of: UBERON:0000014 ! zone of skin intersection_of: BFO:0000050 UBERON:0000989 ! part of penis relationship: BFO:0000050 UBERON:0000989 ! part of penis relationship: RO:0002150 UBERON:0001085 ! continuous with skin of trunk [Term] id: UBERON:0001332 name: prepuce of penis def: "A retractable double-layered fold of skin and mucous membrane that covers the glans penis and protects the urinary meatus when the penis is not erect." [http://orcid.org/0000-0002-6601-2165, Wikipedia:Foreskin] subset: efo_slim subset: pheno_slim subset: uberon_slim synonym: "foreskin" RELATED [FMA:19639] synonym: "penile prepuce" EXACT [FMA:19639] synonym: "praeputium" RELATED OMO:0003011 [Wikipedia:Foreskin] synonym: "prepuce" BROAD [MA:0000407, Wikipedia:Foreskin] synonym: "prepuce of male" EXACT [EMAPA:18989] synonym: "prepucium" RELATED OMO:0003011 [Wikipedia:Foreskin] synonym: "preputium" BROAD [HP:0100587] synonym: "preputium penis" EXACT OMO:0003011 [FMA:19639, FMA:TA] xref: BTO:0001113 xref: CALOHA:TS-0383 xref: EFO:0001664 xref: EMAPA:18989 xref: FMA:19639 xref: MA:0000407 xref: NCIT:C33049 xref: SCTID:181426005 xref: UMLS:C0227952 {source="ncithesaurus:Male_Prepuce"} xref: Wikipedia:Foreskin is_a: UBERON:0011374 ! prepuce intersection_of: UBERON:0011374 ! prepuce intersection_of: BFO:0000050 UBERON:0000989 ! part of penis relationship: BFO:0000050 UBERON:0000989 ! part of penis relationship: RO:0002220 UBERON:0001299 ! adjacent to glans penis relationship: RO:0002494 UBERON:0035005 ! transformation of preputial swelling of male property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/en/thumb/c/cc/Foreskin2.jpg/200px-Foreskin2.jpg" xsd:anyURI property_value: foaf:depiction "https://upload.wikimedia.org/wikipedia/commons/e/e6/Foreskin_CloseupV2.jpg" xsd:anyURI [Term] id: UBERON:0001333 name: male urethra def: "A urethra that is part of a male reproductive system." [http://orcid.org/0000-0002-6601-2165] subset: pheno_slim subset: uberon_slim xref: BTO:0004089 xref: EMAPA:18692 xref: FMA:19668 xref: MA:0002640 xref: NCIT:C33050 xref: SCTID:264085007 xref: UMLS:C0458452 {source="ncithesaurus:Male_Urethra"} xref: Wikipedia:Male_urethra is_a: UBERON:0000057 ! urethra intersection_of: UBERON:0000057 ! urethra intersection_of: BFO:0000050 UBERON:0003101 ! part of male organism relationship: BFO:0000050 UBERON:0003101 ! part of male organism property_value: foaf:depiction "https://upload.wikimedia.org/wikipedia/commons/c/cb/Female_anatomy.png" xsd:anyURI [Term] id: UBERON:0001334 name: female urethra def: "A urethra that is part of a female reproductive system." [http://orcid.org/0000-0002-6601-2165] subset: pheno_slim subset: uberon_slim synonym: "urethra feminina" RELATED [BTO:0004088] synonym: "urethra muliebris" RELATED [BTO:0004088] xref: BTO:0004088 xref: EMAPA:28747 xref: FMA:19669 xref: MA:0002637 xref: NCIT:C32591 xref: SCTID:264469008 xref: UMLS:C0458485 {source="ncithesaurus:Female_Urethra"} xref: Wikipedia:Female_urethra is_a: UBERON:0000057 ! urethra intersection_of: UBERON:0000057 ! urethra intersection_of: BFO:0000050 UBERON:0003100 ! part of female organism relationship: BFO:0000050 UBERON:0003100 ! part of female organism property_value: foaf:depiction "https://upload.wikimedia.org/wikipedia/commons/c/cb/Female_anatomy.png" xsd:anyURI [Term] id: UBERON:0001335 name: prostatic urethra def: "The widest and most dilatable part of the male urethra canal which runs almost vertically through the prostate from its base to its apex, lying nearer its anterior than its posterior surface; this portion of the urethral canal is spindle-shaped, being wider in the middle than at either extremity, and narrowest below, where it joins the membranous portion; it is lined by transitional epithelium and contains in its posterior wall, or floor, the orifices of the prostatic utricle, ejaculatory ducts, and prostatic ducts, collectively known as the seminal colliculus (aka verumontanum)." [MGI:anna, MP:0011777] subset: pheno_slim subset: uberon_slim synonym: "male prostatic urethra" EXACT [MP:0011777] synonym: "pars prostatica urethrae" EXACT OMO:0003011 [MP:0011777, Wikipedia:Prostatic_urethra] synonym: "pars prostatica urethrae" RELATED [BTO:0003163] synonym: "prostatic part of male urethra" EXACT [MP:0011777] synonym: "prostatic part of urethra" EXACT [] xref: BTO:0003163 xref: EMAPA:30942 xref: FMA:19673 xref: MA:0002646 xref: NCIT:C13101 xref: SCTID:279434009 xref: UMLS:C0458450 {source="ncithesaurus:Prostatic_Portion_of_the_Male_Urethra"} xref: Wikipedia:Prostatic_urethra is_a: UBERON:0013522 ! subdivision of tube relationship: BFO:0000050 UBERON:0001333 {source="FMA", source="MA"} ! part of male urethra relationship: RO:0001025 UBERON:0002367 {source="FMA"} ! located in prostate gland relationship: RO:0002433 UBERON:0001333 ! contributes to morphology of male urethra property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/d/d7/Gray1142.png" xsd:anyURI [Term] id: UBERON:0001338 name: urethral gland def: "Any of the numerous small mucous-secreting glands located in the wall of the male or female urethra that help protect the epithelium from the corrosive urine." [MP:anna] subset: organ_slim subset: pheno_slim subset: uberon_slim synonym: "gland of urethra" EXACT [OBOL:automatic] synonym: "urethra gland" EXACT [] synonym: "urethra gland (male or female)" EXACT [] synonym: "urethral mucuous gland" EXACT [] xref: EMAPA:37784 {source="MA:th"} xref: FMA:19683 xref: MA:0001688 xref: SCTID:279477005 is_a: UBERON:0000414 {source="MP"} ! mucous gland intersection_of: UBERON:0002530 ! gland intersection_of: BFO:0000050 UBERON:0000057 ! part of urethra relationship: BFO:0000050 UBERON:0000057 ! part of urethra relationship: RO:0002162 NCBITaxon:40674 ! in taxon Mammalia relationship: RO:0002433 UBERON:0000057 ! contributes to morphology of urethra [Term] id: UBERON:0001343 name: seminiferous tubule of testis def: "The tubules in the testes where spermatogenesis occurs." [https://github.com/obophenotype/uberon/issues/1381, ISBN:0-683-40008-8, MGI:csmith, MP:0002216] subset: efo_slim subset: pheno_slim subset: uberon_slim synonym: "seminiferous cord" EXACT [EMAPA:18685] synonym: "seminiferous tubule" EXACT [] synonym: "testis - seminiferous tubule" EXACT [] synonym: "tubuli seminiferi" EXACT [] synonym: "tubuli seminiferi" RELATED OMO:0003011 [Wikipedia:Seminiferous_tubule] xref: AAO:0010399 xref: BTO:0001235 xref: CALOHA:TS-1239 xref: EFO:0001404 xref: EMAPA:18685 xref: EMAPA:31476 xref: EV:0100380 xref: FMA:19825 xref: GAID:400 xref: MA:0000412 xref: MAT:0000503 xref: MESH:D012671 xref: NCIT:C13047 xref: NCIT:C34293 xref: SCTID:279614002 xref: UMLS:C0036630 {source="ncithesaurus:Seminiferous_Tubule"} xref: UMLS:C1519236 {source="ncithesaurus:Seminiferous_Cord"} xref: VHOG:0001363 xref: Wikipedia:Seminiferous_tubule xref: XAO:0003088 is_a: UBERON:0000025 ! tube is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0005904 ! duct of male reproductive system relationship: BFO:0000050 UBERON:0000473 ! part of testis relationship: BFO:0000067 GO:0007283 ! contains process spermatogenesis relationship: channel_for CL:0000019 ! sperm relationship: RO:0002202 UBERON:0005297 {source="Wikipedia"} ! develops from testis sex cord property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/4/49/Seminiferous_tubule_and_sperm_low_mag.jpg" xsd:anyURI property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/6/6a/Gray1145.png" xsd:anyURI [Term] id: UBERON:0001344 name: epithelium of vagina def: "The epithelial layer of the vagina." [MP:0001140] subset: pheno_slim synonym: "epithelial tissue of vagina" EXACT [OBOL:automatic] synonym: "epithelium, vaginal" RELATED [BTO:0000422] synonym: "vagina epithelial tissue" EXACT [OBOL:automatic] synonym: "vagina epithelium" EXACT [] synonym: "vaginal epithelium" EXACT [] xref: BTO:0000422 xref: CALOHA:TS-1325 xref: EMAPA:30991 xref: FMA:19978 xref: MA:0001730 xref: NCIT:C49313 xref: UMLS:C0920840 {source="ncithesaurus:Vaginal_Epithelium"} is_a: UBERON:0000486 ! multilaminar epithelium is_a: UBERON:0004804 ! oviduct epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: BFO:0000050 UBERON:0000996 ! part of vagina relationship: BFO:0000050 UBERON:0000996 ! part of vagina relationship: RO:0002433 UBERON:0000996 ! contributes to morphology of vagina [Term] id: UBERON:0001347 name: white adipose tissue def: "Connective tissue consisting of fat-storing cells and arranged in lobular groups or along minor blood vessels[MP,modified]." [ISBN:0-683-40008-8, MP:0005670] subset: efo_slim subset: pheno_slim subset: uberon_slim synonym: "adipocytus unigutturalis" EXACT [] synonym: "textus adiposus albus" EXACT [] synonym: "textus adiposus albus" RELATED OMO:0003011 [Wikipedia:White_adipose_tissue] synonym: "unilocular adipose tissue" EXACT [] synonym: "white fat" EXACT [] xref: BTO:0001456 xref: CALOHA:TS-1119 xref: EFO:0000813 xref: EMAPA:35926 xref: FMA:20117 xref: MA:0000058 xref: MAT:0000199 xref: MIAA:0000199 xref: NCIT:C33889 xref: UMLS:C1704223 {source="ncithesaurus:White_Adipose_Tissue"} xref: Wikipedia:White_adipose_tissue is_a: UBERON:0001013 ! adipose tissue intersection_of: UBERON:0001013 ! adipose tissue intersection_of: RO:0002473 CL:0000448 ! composed primarily of white adipocyte relationship: RO:0002473 CL:0000448 ! composed primarily of white adipocyte [Term] id: UBERON:0001348 name: brown adipose tissue def: "A thermogenic form of adipose tissue that is composed of brown adipocytes[MP,modified]." [MGI:smb, MP:0011698] subset: efo_slim subset: pheno_slim subset: uberon_slim synonym: "adipocytus multigutturalis" EXACT [] synonym: "BAT" RELATED OMO:0003000 [Wikipedia:Brown_adipose_tissue] synonym: "brown fat" EXACT [] synonym: "multilocular adipose tissue" EXACT [] synonym: "textus adiposus fuscus" EXACT [] synonym: "textus adiposus fuscus" RELATED OMO:0003011 [Wikipedia:Brown_adipose_tissue] xref: BTO:0000156 xref: CALOHA:TS-0099 xref: EFO:0000812 xref: EMAPA:19209 xref: FMA:20118 xref: GAID:921 xref: MA:0000057 xref: MAT:0000198 xref: MESH:D002001 xref: MIAA:0000198 xref: NCIT:C32235 xref: SCTID:15965003 xref: UMLS:C0006298 {source="ncithesaurus:Brown_Adipose_Tissue"} xref: Wikipedia:Brown_adipose_tissue is_a: UBERON:0001013 ! adipose tissue intersection_of: UBERON:0001013 ! adipose tissue intersection_of: RO:0002473 CL:0000449 ! composed primarily of brown adipocyte relationship: RO:0002215 GO:1990845 ! capable of adaptive thermogenesis relationship: RO:0002473 CL:0000449 ! composed primarily of brown adipocyte property_value: foaf:depiction "https://upload.wikimedia.org/wikipedia/commons/6/69/Brownfat_PETCT.jpg" xsd:anyURI [Term] id: UBERON:0001351 name: lacrimal sac def: "The upper dilated end of the nasolacrimal duct that is lodged in a deep groove formed by the lacrimal bone and frontal process of the maxilla; it connects the lacrimal canaliculi, which drain tears from the eye's surface, and the nasolacrimal duct, which conveys this fluid into the nasal cavity; like the nasolacrimal duct, the sac is lined by stratified columnar epithelium with mucus-secreting goblet cells, and is surrounded by connective tissue." [MGI:anna] subset: pheno_slim subset: uberon_slim synonym: "lachrymal sac" EXACT [] synonym: "lacrymal sac" EXACT [] synonym: "saccus lacrimalis" EXACT OMO:0003011 [Wikipedia:Lacrimal_sac] xref: FMA:20289 xref: MA:0001298 xref: NCIT:C32909 xref: SCTID:362534009 xref: UMLS:C0229289 {source="ncithesaurus:Lacrimal_Sac"} xref: Wikipedia:Lacrimal_sac is_a: UBERON:0034944 ! zone of organ relationship: BFO:0000050 UBERON:0002392 ! part of nasolacrimal duct property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/c/cf/Gray896.png" xsd:anyURI [Term] id: UBERON:0001352 name: external acoustic meatus def: "A tube running from the outer ear to the middle ear. The human ear canal extends from the pinna to the eardrum and is about 26 mm in length and 7 mm in diameter." [Wikipedia:External_acoustic_meatus] subset: pheno_slim subset: uberon_slim synonym: "auditory canal" EXACT [] synonym: "auditory meatus" RELATED [EHDAA2:0000460] synonym: "ear canal" EXACT [Wikipedia:Ear_canal] synonym: "external acoustic tube" EXACT [FMA:61734] synonym: "external auditory canal" EXACT [] synonym: "external auditory meatus" RELATED [] synonym: "external auditory tube" EXACT [FMA:61734] xref: EHDAA2:0000460 xref: EHDAA:8975 xref: EMAPA:17588 xref: EV:0100356 xref: FMA:61734 xref: GAID:864 xref: galen:ExternalAuditoryMeatus xref: MA:0000260 xref: MESH:D004424 xref: NCIT:C12498 xref: SCTID:181178004 xref: UMLS:C0013444 {source="ncithesaurus:External_Acoustic_Meatus"} xref: VHOG:0000977 xref: Wikipedia:External_acoustic_meatus is_a: BFO:0000002 is_a: UBERON:0004111 ! anatomical conduit relationship: BFO:0000050 UBERON:0001691 {source="FMA"} ! part of external ear relationship: RO:0002202 UBERON:0005872 {source="PMID:11237469"} ! develops from 1st arch pharyngeal cleft relationship: RO:0002216 GO:0055127 ! capable of part of vibrational conductance of sound to the inner ear relationship: RO:0002219 UBERON:0010065 {source="EHDAA2"} ! surrounded by auditory meatus epithelium property_value: IAO:0000116 "consider revisiting superclass after refinement of CARO/EAO, conduit may not be quite correct." xsd:string [Term] id: UBERON:0001353 name: anal region def: "The anus and surrounding regions. Encompasses both internal and external regions, where present." [https://orcid.org/0000-0002-6601-2165] subset: efo_slim subset: pheno_slim subset: uberon_slim synonym: "posterior" RELATED [] synonym: "posterior end of organism" RELATED [] xref: EFO:0000847 xref: EHDAA2:0000122 xref: EHDAA:2931 xref: EMAPA:16831 xref: MA:0000329 xref: MAT:0000042 xref: MIAA:0000042 xref: NCIT:C32069 xref: SCTID:362680001 xref: UMLS:C0230120 {source="ncithesaurus:Anal_Region"} xref: VHOG:0000395 xref: WBbt:0006919 is_a: BFO:0000002 is_a: UBERON:0000475 ! organism subdivision relationship: RO:0002131 UBERON:0006866 ! overlaps terminal part of digestive tract relationship: RO:0002254 UBERON:0000931 {evidence="cjm"} ! has developmental contribution from proctodeum property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/f/fb/Gray408.png" xsd:anyURI property_value: seeAlso "https://github.com/obophenotype/uberon/issues/507" xsd:anyURI property_value: skos:prefLabel "anal region" xsd:string [Term] id: UBERON:0001355 name: deep femoral artery def: "The profunda femoris artery (also known as the deep femoral artery, or the deep artery of the thigh) is a branch of the femoral artery that, as its name suggests, travels more deeply (posteriorly) than the rest of the femoral artery. [WP,unvetted]." [Wikipedia:Deep_femoral_artery] subset: human_reference_atlas subset: uberon_slim synonym: "arteria profunda femoris" EXACT [] synonym: "profunda femoris artery" EXACT [] xref: EMAPA:37216 {source="MA:th"} xref: FMA:20741 xref: MA:0002027 xref: NCIT:C32436 xref: SCTID:181348000 xref: UMLS:C0226455 {source="ncithesaurus:Deep_Femoral_Artery"} xref: Wikipedia:Deep_femoral_artery is_a: UBERON:0001637 ! artery intersection_of: UBERON:0001637 ! artery intersection_of: BFO:0000050 UBERON:0035551 ! part of deep vasculature intersection_of: RO:0002252 UBERON:0002060 ! connecting branch of femoral artery relationship: BFO:0000050 UBERON:0035551 ! part of deep vasculature relationship: RO:0002252 UBERON:0002060 ! connecting branch of femoral artery property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/8/8b/Gray548.png" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001356 name: medial circumflex femoral artery def: "The medial circumflex femoral artery (internal circumflex artery, medial femoral circumflex artery) is an artery in the upper thigh that helps supply blood to the neck of the femur. [WP,unvetted]." [Wikipedia:Medial_circumflex_femoral_artery] subset: human_reference_atlas subset: uberon_slim synonym: "arteria circumflexa femoris medialis" RELATED OMO:0003011 [Wikipedia:Medial_circumflex_femoral_artery] synonym: "medial femoral circumflex artery" EXACT [] xref: EMAPA:37670 {source="MA:th"} xref: FMA:20799 xref: MA:0001996 xref: SCTID:244326008 xref: Wikipedia:Medial_circumflex_femoral_artery is_a: UBERON:0001637 ! artery intersection_of: UBERON:0001637 ! artery intersection_of: RO:0020101 UBERON:0007119 ! vessel supplies blood to neck of femur relationship: RO:0002252 UBERON:0001355 {source="FMA"} ! connecting branch of deep femoral artery relationship: RO:0020101 UBERON:0007119 ! vessel supplies blood to neck of femur property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/c/c5/Circumflex_femoral_arteries.png" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001359 name: cerebrospinal fluid def: "A clear, colorless, bodily fluid, that occupies the subarachnoid space and the ventricular system around and inside the brain and spinal cord." [Wikipedia:Cerebrospinal_fluid] subset: efo_slim subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "cerebral spinal fluid" EXACT [ZFA:0001626] synonym: "CSF" EXACT [] synonym: "liquor cerebrospinalis" RELATED [Wikipedia:Cerebrospinal_fluid] synonym: "spinal fluid" RELATED [BTO:0000237] xref: BIRNLEX:1798 xref: BTO:0000237 xref: CALOHA:TS-0130 xref: EFO:0000329 xref: EHDAA2:0004441 xref: ENVO:02000029 xref: EV:0100311 xref: FMA:20935 xref: GAID:1181 xref: MA:0002503 xref: MAT:0000499 xref: MESH:D002555 xref: NCIT:C12692 xref: TAO:0002184 xref: UMLS:C0007806 {source="BIRNLEX:1798", source="ncithesaurus:Cerebrospinal_Fluid"} xref: VHOG:0001278 xref: Wikipedia:Cerebrospinal_fluid xref: ZFA:0001626 is_a: UBERON:0007779 {source="Wikipedia"} ! transudate relationship: filtered_through UBERON:0001886 ! choroid plexus relationship: RO:0001025 UBERON:0005281 {source="EHDAA2"} ! located in ventricular system of central nervous system relationship: RO:0002202 UBERON:0002307 ! develops from choroid plexus of lateral ventricle property_value: IAO:0000116 "many sources state the CP as sole producer of CSF, but this is disputed [DOI:10.1007/s11064-015-1581-6]" xsd:string property_value: skos:prefLabel "cerebrospinal fluid" xsd:string [Term] id: UBERON:0001361 name: femoral vein def: "In the human body, the femoral vein is a blood vessel that accompanies the femoral artery in the femoral sheath. It begins at the adductor canal (also known as Hunter's canal) and is a continuation of the popliteal vein. It ends at the inferior margin of the inguinal ligament, where it becomes the external iliac vein. [WP,unvetted]." [Wikipedia:Femoral_vein] subset: human_reference_atlas subset: uberon_slim synonym: "vena femoralis" RELATED OMO:0003011 [Wikipedia:Femoral_vein] xref: AAO:0010237 xref: EMAPA:17876 xref: FMA:21185 xref: GAID:533 xref: galen:FemoralVein xref: MA:0002118 xref: MESH:D005268 xref: NCIT:C12716 xref: SCTID:362071002 xref: UMLS:C0015809 {source="ncithesaurus:Femoral_Vein"} xref: Wikipedia:Femoral_vein is_a: UBERON:0001638 ! vein is_a: UBERON:0003516 ! hindlimb blood vessel relationship: RO:0002170 UBERON:0001316 ! connected to external iliac vein property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001363 name: great saphenous vein def: "The great saphenous vein (GSV), also greater saphenous vein, is the large (subcutaneous) superficial vein of the leg and thigh. The terms 'safaina' (Greek) and 'el safin' (Arabic) have both been claimed as the origin for the word 'saphenous'. [WP,unvetted]." [Wikipedia:Great_saphenous_vein] subset: human_reference_atlas subset: uberon_slim synonym: "greater saphenous vein" EXACT [] synonym: "large saphenous vein" RELATED [BTO:0003271] synonym: "long saphenous vein" RELATED [] synonym: "vena saphena magna" RELATED OMO:0003011 [Wikipedia:Great_saphenous_vein] xref: BTO:0003271 xref: EMAPA:37147 {source="MA:th"} xref: FMA:21376 xref: galen:GreaterSaphenousVein xref: galen:GreatSaphenousVein xref: MA:0002216 xref: NCIT:C33004 xref: SCTID:181402008 xref: UMLS:C0392907 {source="ncithesaurus:Long_Saphenous_Vein"} xref: Wikipedia:Great_saphenous_vein is_a: UBERON:0007318 ! saphenous vein relationship: RO:0002376 UBERON:0001361 {source="FMA/obol"} ! tributary of femoral vein property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/5/51/Great_saphenous_vein.png" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001366 name: parietal peritoneum def: "The outer layer of peritoneum that is attached to the abdominal and pelvic walls." [http://orcid.org/0000-0002-6601-2165, Wikipedia:Peritoneum#Types] subset: uberon_slim subset: vertebrate_core synonym: "parietal serous membrane of peritoneum" EXACT [UBERON:cjm] synonym: "peritoneal cavity lining" RELATED [] xref: AAO:0010816 xref: EMAPA:16591 xref: FMA:21451 xref: SCTID:362700006 xref: TAO:0005131 xref: VHOG:0001527 xref: Wikipedia:Parietal_peritoneum xref: ZFA:0005131 is_a: UBERON:0022351 ! parietal serous membrane intersection_of: UBERON:0022351 ! parietal serous membrane intersection_of: BFO:0000050 UBERON:0002358 ! part of peritoneum relationship: BFO:0000050 UBERON:0002358 ! part of peritoneum relationship: RO:0002371 UBERON:0003697 ! attached to abdominal wall property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/5/5f/Gray1040.png" xsd:anyURI property_value: skos:prefLabel "parietal peritoneum" xsd:string [Term] id: UBERON:0001383 name: muscle of leg def: "A muscle that is part of the region of the hindlimb between the pelvis and ankle." [https://orcid.org/0000-0002-6601-2165, Wikipedia:Leg_muscle] subset: human_reference_atlas subset: pheno_slim subset: uberon_slim synonym: "leg muscle" EXACT [] synonym: "leg muscle organ" EXACT [OBOL:automatic] synonym: "leg skeletal muscle" EXACT [OBOL:automatic] synonym: "leg skeletal muscle tissue" EXACT [OBOL:automatic] synonym: "muscle of hindlimb zeugopod or stylopod" EXACT [https://orcid.org/0000-0002-6601-2165, OBOL:automatic] synonym: "muscle of thigh or crus" EXACT [https://orcid.org/0000-0002-6601-2165, OBOL:automatic] synonym: "muscle of upper or lower hindlimb segment" EXACT [https://orcid.org/0000-0002-6601-2165, OBOL:automatic] synonym: "muscle of upper/lower leg" EXACT [] synonym: "muscle organ of leg" EXACT [OBOL:automatic] synonym: "skeletal muscle of leg" EXACT [OBOL:automatic] xref: BTO:0000722 xref: EHDAA:8291 xref: MA:0000672 xref: RETIRED_EHDAA2:0000974 xref: Wikipedia:Leg_muscle is_a: UBERON:0003663 ! hindlimb muscle intersection_of: UBERON:0014892 ! skeletal muscle organ, vertebrate intersection_of: BFO:0000050 UBERON:0000978 ! part of leg relationship: BFO:0000050 UBERON:0004466 {source="prolog"} ! part of musculature of leg property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001384 name: primary motor cortex def: "The part of the cerebral cortex that receives projections from the motor thalamus and which projects to motor neurons in the brainstem and spinal cord. The motor cortex corresponds to Brodmann's area 4 (MM). The primary motor cortex, or M1, is located on the precentral gyrus and on the anterior paracentral lobule on the medial surface of the brain. Of the three motor cortex areas, stimulation of the primary motor cortex requires the least amount of electrical current to elicit a movement. http://neuroscience.uth.tmc.edu/s3/chapter03.html." [NLX:143555] subset: efo_slim subset: human_reference_atlas subset: pheno_slim subset: uberon_slim synonym: "excitable area" RELATED [BTO:0004348] synonym: "gyrus precentralis" RELATED OMO:0003011 [Wikipedia:Primary_motor_cortex] synonym: "motor area" RELATED [BTO:0004348] synonym: "motor cortex" EXACT [FMA:224854] synonym: "prefrontal gyrus" RELATED [MP:0000798, Wikipedia:Primary_motor_cortex] synonym: "primary motor area" RELATED [BAMS:MOp] synonym: "Rolando's area" RELATED [BTO:0004348] synonym: "somatic motor areas" RELATED [BAMS:MO] synonym: "somatomotor areas" RELATED [BAMS:MO] xref: BAMS:M1 xref: BAMS:MO xref: BAMS:MOp xref: BM:Tel-Cx-M1 xref: BTO:0004348 xref: DHBA:10162 xref: EFO:0002472 xref: EMAPA:35704 xref: FMA:224854 xref: MA:0000907 xref: MBA:985 xref: MESH:D009044 xref: NCIT:C97339 xref: neuronames:1910 xref: NLX:143555 xref: SCTID:11931008 xref: UMLS:C0026607 {source="ncithesaurus:Primary_Motor_Cortex"} xref: Wikipedia:Primary_motor_cortex is_a: UBERON:0002616 ! regional part of brain relationship: BFO:0000050 UBERON:0001870 {source="MA", source="Wikipedia"} ! part of frontal cortex relationship: RO:0002433 UBERON:0000956 ! contributes to morphology of cerebral cortex relationship: RO:0002433 UBERON:0001870 ! contributes to morphology of frontal cortex property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/e/eb/Ba4.png" xsd:anyURI property_value: IAO:0000116 "TODO - in MA this is asserted to be part_of BOTH frontal and parietal cortex. in ABA these are disjoint. FMA makes no commitment beyond cerebral cortex. Wikipedia says frontal lobe. Check if species difference or difference in definition. Removed relationship: part_of UBERON:0001872 parietal lobe" xsd:string property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "primary motor cortex" xsd:string [Term] id: UBERON:0001394 name: axillary artery def: "Artery that supplies the axilla." [http://orcid.org/0000-0002-6601-2165] subset: human_reference_atlas subset: uberon_slim synonym: "arteria axillaris" EXACT OMO:0003011 [Wikipedia:Axillary_artery] synonym: "axillary part of subclavian artery" EXACT [FMA:22654] synonym: "axillary part of trunk of subclavian artery" EXACT [] xref: EMAPA:18749 xref: FMA:22654 xref: GAID:473 xref: galen:AxillaryArtery xref: MA:0002573 xref: MESH:D001366 xref: NCIT:C32169 xref: SCTID:181321001 xref: UMLS:C0004455 {source="ncithesaurus:Axillary_Artery"} xref: Wikipedia:Axillary_artery is_a: UBERON:0001637 ! artery intersection_of: UBERON:0001637 ! artery intersection_of: RO:0020101 UBERON:0009472 ! vessel supplies blood to axilla relationship: BFO:0000050 UBERON:0001467 ! part of shoulder relationship: RO:0002170 UBERON:0001533 ! connected to subclavian artery relationship: RO:0002252 UBERON:0001394 ! connecting branch of axillary artery relationship: RO:0020101 UBERON:0009472 ! vessel supplies blood to axilla property_value: foaf:depiction "https://upload.wikimedia.org/wikipedia/commons/8/88/Axillary_limits.PNG" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001397 name: subscapular artery def: "The subscapular artery, the largest branch of the axillary artery, arises at the lower border of the Subscapularis, which it follows to the inferior angle of the scapula, where it anastomoses with the lateral thoracic and intercostal arteries and with the descending branch of the transverse cervical, and ends in the neighboring muscles. About 4 cm. from its origin it gives off two branches, first the scapular circumflex artery and then the thoracodorsal artery. [WP,unvetted]." [Wikipedia:Subscapular_artery] subset: human_reference_atlas subset: uberon_slim synonym: "arteria subscapularis" RELATED OMO:0003011 [Wikipedia:Subscapular_artery] xref: EMAPA:37116 {source="MA:th"} xref: FMA:22677 xref: MA:0002050 xref: NCIT:C33650 xref: SCTID:244311006 xref: UMLS:C0226422 {source="ncithesaurus:Subscapular_Artery"} xref: Wikipedia:Subscapular_artery is_a: UBERON:0001637 ! artery relationship: RO:0002170 UBERON:0001394 ! connected to axillary artery property_value: foaf:depiction "https://upload.wikimedia.org/wikipedia/commons/4/4c/Axillary_branches.PNG" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001415 name: skin of pelvis def: "A zone of skin that is part of a pelvis [Automatically generated definition]." [OBOL:automatic] synonym: "pelvic skin" EXACT [] synonym: "pelvis skin" EXACT [] synonym: "pelvis zone of skin" EXACT [OBOL:automatic] synonym: "zone of skin of pelvis" EXACT [OBOL:automatic] xref: EMAPA:37282 {source="MA:th"} xref: FMA:22984 xref: MA:0000546 xref: SCTID:181517009 is_a: UBERON:0003836 ! abdominal segment skin intersection_of: UBERON:0000014 ! zone of skin intersection_of: BFO:0000050 UBERON:0002355 ! part of pelvic region of trunk relationship: BFO:0000050 UBERON:0002355 ! part of pelvic region of trunk [Term] id: UBERON:0001416 name: skin of abdomen def: "A zone of skin that is part of an abdomen [Automatically generated definition]." [OBOL:automatic] subset: efo_slim subset: pheno_slim synonym: "abdomen skin" EXACT [] synonym: "abdomen zone of skin" EXACT [OBOL:automatic] synonym: "abdominal skin" EXACT [] synonym: "skin of abdomen proper" EXACT [FMA:22988] synonym: "zone of skin of abdomen" EXACT [OBOL:automatic] xref: EFO:0000214 xref: FMA:22988 xref: FMA:23000 xref: MA:0000523 xref: NCIT:C52758 xref: SCTID:361707007 xref: UMLS:C0222166 {source="ncithesaurus:Abdominal_Skin"} is_a: UBERON:0003836 ! abdominal segment skin intersection_of: UBERON:0000014 ! zone of skin intersection_of: BFO:0000050 UBERON:0000916 ! part of abdomen relationship: BFO:0000050 UBERON:0000916 ! part of abdomen property_value: skos:prefLabel "skin of abdomen" xsd:string [Term] id: UBERON:0001417 name: skin of neck def: "A zone of skin that is part of a neck [Automatically generated definition]." [OBOL:automatic] synonym: "neck (volume) zone of skin" EXACT [OBOL:automatic] synonym: "neck skin" EXACT [] synonym: "neck zone of skin" EXACT [OBOL:automatic] synonym: "zone of skin of neck" EXACT [OBOL:automatic] synonym: "zone of skin of neck (volume)" EXACT [OBOL:automatic] xref: EMAPA:37277 {source="MA:th"} xref: FMA:23021 xref: FMA:23022 xref: MA:0000590 xref: NCIT:C52756 xref: SCTID:361705004 xref: UMLS:C0205030 {source="ncithesaurus:Neck_Skin"} is_a: UBERON:0000014 ! zone of skin intersection_of: UBERON:0000014 ! zone of skin intersection_of: BFO:0000050 UBERON:0000974 ! part of neck relationship: BFO:0000050 UBERON:0000974 ! part of neck property_value: skos:prefLabel "skin of neck" xsd:string [Term] id: UBERON:0001418 name: skin of thorax def: "A zone of skin that is part of a thorax [Automatically generated definition]." [OBOL:automatic] synonym: "thoracic skin" EXACT [] synonym: "thorax skin" EXACT [] synonym: "thorax zone of skin" EXACT [OBOL:automatic] synonym: "upper body skin" RELATED [] synonym: "zone of skin of thorax" EXACT [OBOL:automatic] xref: EMAPA:37765 {source="MA:th"} xref: FMA:23028 xref: FMA:23029 xref: MA:0000564 xref: SCTID:281723000 is_a: UBERON:0001085 ! skin of trunk intersection_of: UBERON:0000014 ! zone of skin intersection_of: BFO:0000050 UBERON:0000915 ! part of thoracic segment of trunk relationship: BFO:0000050 UBERON:0000915 ! part of thoracic segment of trunk property_value: skos:prefLabel "skin of thorax" xsd:string [Term] id: UBERON:0001419 name: skin of limb def: "A zone of skin that is part of a limb [Automatically generated definition]." [OBOL:automatic] subset: pheno_slim synonym: "limb skin" EXACT [] synonym: "limb zone of skin" EXACT [OBOL:automatic] synonym: "zone of skin of limb" EXACT [OBOL:automatic] xref: EMAPA:32726 xref: FMA:23100 xref: MA:0000694 xref: NCIT:C53276 xref: SCTID:314403009 xref: UMLS:C1282135 {source="ncithesaurus:Skin_of_the_Extremity"} is_a: UBERON:0000014 ! zone of skin intersection_of: UBERON:0000014 ! zone of skin intersection_of: BFO:0000050 UBERON:0002101 ! part of limb relationship: BFO:0000050 UBERON:0002101 ! part of limb [Term] id: UBERON:0001421 name: pectoral girdle region def: "An organism subdivision that includes the pectoral girdle skeleton and associated soft tissue. Note that this includes both the skeletal elements and associated tissues (integument, muscle, etc). Examples: There are only two instances in an organism, right and left pectoral girdle regions." [FMA:23217, https://orcid.org/0000-0002-6601-2165, UBERONREF:0000003] subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "cingulum membri superioris" EXACT OMO:0003011 [FMA:23217, FMA:TA] synonym: "cingulum membri superioris" NARROW [FMA:TA] synonym: "girdle - pectoral" EXACT [] synonym: "pectoral girdle" RELATED [] synonym: "pectoral region" RELATED [] synonym: "shoulder girdle" NARROW [FMA:23217] synonym: "upper limb girdle" NARROW [FMA:23217] xref: EMAPA:37856 {source="MA:th"} xref: FMA:23217 xref: galen:ShoulderGirdle xref: SCTID:229759004 xref: VSAO:0000305 is_a: UBERON:0007823 ! appendage girdle region is_a: UBERON:0015212 ! lateral structure intersection_of: UBERON:0007823 ! appendage girdle region intersection_of: BFO:0000050 UBERON:0010708 ! part of pectoral complex disjoint_from: UBERON:0007831 ! pectoral girdle skeleton relationship: BFO:0000050 UBERON:0010708 ! part of pectoral complex relationship: BSPO:0000126 UBERON:0000468 ! multicellular organism relationship: RO:0002551 UBERON:0007831 ! has skeleton pectoral girdle skeleton property_value: skos:prefLabel "pectoral girdle region" xsd:string [Term] id: UBERON:0001422 name: facial lymphatic vessel def: "A lymphatic vessel that is part of a face [Automatically generated definition]." [OBOL:automatic] subset: vertebrate_core synonym: "buccal lymphatic vessel" EXACT [] synonym: "face lymph vessel" EXACT [OBOL:automatic] synonym: "face lymphatic vessel" EXACT [OBOL:automatic] synonym: "FL" RELATED [] synonym: "lymph vessel of face" EXACT [OBOL:automatic] synonym: "lymphatic vessel of face" EXACT [OBOL:automatic] xref: FMA:233946 xref: TAO:0005108 xref: ZFA:0005108 is_a: UBERON:0001473 ! lymphatic vessel intersection_of: UBERON:0001473 ! lymphatic vessel intersection_of: BFO:0000050 UBERON:0001456 ! part of face relationship: BFO:0000050 UBERON:0001456 ! part of face relationship: BFO:0000050 UBERON:0011363 ! part of cranial lymph vasculature [Term] id: UBERON:0001425 name: pectoral lymphatic vessel subset: vertebrate_core synonym: "PL" RELATED OMO:0003000 [] xref: FMA:234865 xref: TAO:0005107 xref: ZFA:0005107 is_a: UBERON:0001473 ! lymphatic vessel intersection_of: UBERON:0001473 ! lymphatic vessel intersection_of: BFO:0000050 UBERON:0001421 ! part of pectoral girdle region relationship: BFO:0000050 UBERON:0001421 ! part of pectoral girdle region [Term] id: UBERON:0001434 name: skeletal system def: "Anatomical system that is a multi-element, multi-tissue anatomical cluster that consists of the skeleton and the articular system." [GO_REF:0000034, http://dx.plos.org/10.1371/journal.pone.0051070, VSAO:0000027] subset: efo_slim subset: human_reference_atlas subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "set of all bones and joints" NARROW SENSU [] synonym: "skeleton system" EXACT [] synonym: "Skelettsystem" RELATED [BTO:0001486] xref: AAO:0000566 xref: BTO:0001486 xref: CALOHA:TS-1320 xref: EFO:0000806 xref: EHDAA2:0003168 xref: EMAPA:35773 xref: FMA:23881 xref: MA:0000018 xref: NCIT:C12788 xref: TAO:0000434 xref: UMLS:C0037253 {source="ncithesaurus:Skeletal_System"} xref: VHOG:0001254 xref: VSAO:0000027 xref: XAO:0003060 xref: ZFA:0000434 is_a: UBERON:0011216 ! organ system subdivision intersection_of: UBERON:0011216 ! organ system subdivision intersection_of: BFO:0000051 UBERON:0004288 ! has part skeleton intersection_of: BFO:0000051 UBERON:0004770 ! has part articular system disjoint_from: UBERON:0001474 ! bone element disjoint_from: UBERON:0002204 ! musculoskeletal system disjoint_from: UBERON:0002294 ! biliary system disjoint_from: UBERON:0002330 ! exocrine system disjoint_from: UBERON:0002390 ! hematopoietic system disjoint_from: UBERON:0002405 ! immune system disjoint_from: UBERON:0002416 ! integumental system disjoint_from: UBERON:0002423 ! hepatobiliary system disjoint_from: UBERON:0004456 ! entire sense organ system disjoint_from: UBERON:8450002 ! excretory system relationship: BFO:0000050 UBERON:0002204 ! part of musculoskeletal system relationship: BFO:0000051 UBERON:0004288 ! has part skeleton relationship: BFO:0000051 UBERON:0004770 ! has part articular system relationship: RO:0002492 UBERON:0000066 ! existence ends during fully formed stage property_value: RO:0002175 NCBITaxon:9606 property_value: seeAlso "https://github.com/obophenotype/uberon/wiki/The-skeletal-system" xsd:anyURI property_value: skos:prefLabel "skeletal system" xsd:string [Term] id: UBERON:0001435 name: carpal bone def: "A bone that is part of the carpal skeleton. Examples: scaphoid, lunate, capitate[cjm]." [https://orcid.org/0000-0002-6601-2165] subset: pheno_slim subset: uberon_slim synonym: "bone of carpus" EXACT [] synonym: "carpal" EXACT [PHENOSCAPE:ad] synonym: "carpal skeleton bone" EXACT [] synonym: "carpus bone" RELATED [EMAPA:25056] xref: EMAPA:25056 xref: FMA:23889 xref: GAID:179 xref: galen:CarpalBone xref: MA:0000296 xref: MESH:D002348 xref: NCIT:C12688 xref: SCTID:83936004 xref: UMLS:C0007285 {source="ncithesaurus:Carpal_Bone"} xref: Wikipedia:Carpus is_a: UBERON:0003656 ! mesopodium bone is_a: UBERON:0005897 ! manus bone is_a: UBERON:0015049 ! carpus endochondral element intersection_of: UBERON:0001474 ! bone element intersection_of: BFO:0000050 UBERON:0004452 ! part of carpal region disjoint_from: UBERON:0012358 ! manual digitopodium bone relationship: RO:0002202 UBERON:0006213 ! develops from carpus cartilage element property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/5/58/Carpus.svg" xsd:anyURI [Term] id: UBERON:0001436 name: phalanx of manus def: "A phalanx that is part of a forelimb autopod[Automatically generated definition]." [https://orcid.org/0000-0002-6601-2165, Wikipedia:Phalanges_of_the_hand] subset: pheno_slim synonym: "bone of finger" RELATED [FMA:23914] synonym: "digital bone of manus" NARROW [OBOL:automatic] synonym: "digitus manus phalanx" EXACT [OBOL:automatic] synonym: "finger phalanx" EXACT [OBOL:automatic] synonym: "hand digit phalanx" EXACT [OBOL:automatic] synonym: "hand phalanx" EXACT [MA:0000306] synonym: "manual phalanx" EXACT [] synonym: "phalanges of fore digit" RELATED OMO:0003004 [AAO:0000947] synonym: "phalanx of digit of hand" EXACT [OBOL:automatic] synonym: "phalanx of digitus manus" EXACT [OBOL:automatic] synonym: "phalanx of finger" EXACT [FMA:23914] synonym: "phalanx of fore digit" EXACT [] synonym: "phalanx of hand" EXACT [] synonym: "phalanx of hand digit" EXACT [OBOL:automatic] synonym: "phalanx of manual digit" EXACT [] xref: AAO:0000947 xref: EMAPA:32650 xref: FMA:23914 xref: http://mbe.oxfordjournals.org/content/26/3/613/F1.large.jpg xref: MA:0000306 xref: NCIT:C52771 xref: SCTID:181976001 xref: SCTID:361100001 xref: UMLS:C0223792 {source="ncithesaurus:Hand_Phalanx"} xref: Wikipedia:Phalanges_of_the_hand is_a: UBERON:0003221 ! phalanx is_a: UBERON:0003607 ! forelimb long bone is_a: UBERON:0004249 ! manual digit bone is_a: UBERON:0015024 ! manual digit phalanx endochondral element intersection_of: UBERON:0003221 ! phalanx intersection_of: BFO:0000050 UBERON:0002389 ! part of manual digit relationship: RO:0002202 UBERON:0010686 ! develops from manual digit phalanx cartilage element [Term] id: UBERON:0001437 name: epiphysis def: "The head of a long bone that articulates with a neighboring skeletal element and is separated from the shaft by the epiphyseal plate until bone growth stops. At that time, the plate disappears and the head and shaft are united[MESH,modified]." [http://orcid.org/0000-0002-6601-2165, MESH:A02.835.232.251] subset: pheno_slim subset: uberon_slim synonym: "bone epiphysis" EXACT [] synonym: "end of long bone" EXACT [] synonym: "epiphyses" EXACT OMO:0003004 [] synonym: "long bone epiphysis" EXACT [] xref: AAO:0000742 xref: BTO:0000413 xref: EMAPA:35508 xref: FMA:24012 xref: MA:0001362 xref: MESH:D004838 xref: NCIT:C32529 xref: NCIT:C52722 xref: SCTID:244701002 xref: UMLS:C1708734 {source="ncithesaurus:Long_Bone_Epiphysis"} xref: Wikipedia:Epiphysis is_a: UBERON:0005055 ! zone of long bone relationship: RO:0002433 UBERON:0002495 ! contributes to morphology of long bone property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/9/94/Illu_long_bone.jpg" xsd:anyURI property_value: seeAlso UBERON:0006776 [Term] id: UBERON:0001438 name: metaphysis def: "Zone of long bone that is between the epiphysis and diaphysis. Subdivision of diaphysis which forms the proximal or distal end of diaphysis next to the epiphysis; together with diaphysis proper, it constitutes the diaphysis. Examples: proximal metaphysis of humerus, distal metaphysis of femur.[FMA]." [FMA:24014, Wikipedia:Metaphysis] subset: pheno_slim subset: uberon_slim synonym: "diaphyseal end of long bone" EXACT [] synonym: "long bone metaphysis" EXACT [] synonym: "metaphyses" EXACT OMO:0003004 [] xref: EMAPA:35509 xref: FMA:24014 xref: MA:0001363 xref: NCIT:C52723 xref: SCTID:304581004 xref: UMLS:C0222671 {source="ncithesaurus:Metaphysis"} xref: Wikipedia:Metaphysis is_a: UBERON:0005055 ! zone of long bone relationship: BFO:0000050 UBERON:0004769 ! part of diaphysis relationship: RO:0002220 UBERON:0006861 ! adjacent to diaphysis proper relationship: RO:0002433 UBERON:0002495 ! contributes to morphology of long bone property_value: IAO:0000116 "todo - decide - adjacent to or containing epiphyseal plate? AO Notes: FMA the metaphysis is part of the diaphysis, but not in MA." xsd:string [Term] id: UBERON:0001439 name: compact bone tissue def: "The outer layers of solid, hard bone that covers spongy bone; consists of parallel osteons containing mineral deposits and interstitial lamellae." [ISBN:0-683-40008-8, MGI:hdene, MP:0003797] comment: MP distinguishes compact/cortical bone. in other AOs they are syns subset: pheno_slim subset: uberon_slim synonym: "bony cortex" EXACT [HP:0002753] synonym: "compact bone" EXACT [MA:0001461] synonym: "compact bone tissue" EXACT [] synonym: "cortical bone" EXACT [] synonym: "cortical bone tissue" EXACT [] synonym: "cortical region of bone" EXACT [] synonym: "substantia compacta" EXACT OMO:0003011 [FMA:24018, FMA:TA] synonym: "substantia compacta (pars ossea)" EXACT [] synonym: "substantia corticalis" EXACT OMO:0003011 [FMA:24018, FMA:TA] xref: EMAPA:35250 xref: FMA:24018 xref: galen:CorticalBone xref: MA:0001461 xref: MESH:D000071538 {sssom:mapping_justification="https://w3id.org/semapv/vocab/LexicalMatching"} xref: NCIT:C52714 xref: SCTID:361728003 xref: UMLS:C0222661 {source="ncithesaurus:Cortical_Bone"} xref: Wikipedia:Compact_bone is_a: UBERON:0002481 ! bone tissue relationship: BFO:0000050 UBERON:0002482 ! part of lamellar bone property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/pelvis-female/v1.3/assets/3d-vh-f-pelvis.glb" xsd:anyURI property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/pelvis-male/v1.3/assets/3d-vh-m-pelvis.glb" xsd:anyURI [Term] id: UBERON:0001440 name: forelimb skeleton def: "The collection of all skeletal elements in a free forelimb region. Excludes the pectoral girdle." [https://orcid.org/0000-0002-6601-2165] synonym: "bones of upper limb" EXACT [] synonym: "fore limb skeleton" EXACT [] synonym: "forelimb skeleton" EXACT [VHOG:0001256] synonym: "free upper limb skeleton" EXACT [FMA:24142] synonym: "ossa membri superioris" EXACT OMO:0003011 [FMA:24139, FMA:TA] synonym: "pectoral limb skeleton" EXACT [] synonym: "set of bones of upper limb" EXACT [] synonym: "skeleton of forelimb" EXACT [] synonym: "skeleton of free upper limb" EXACT [FMA:24142] synonym: "skeleton of pectoral limb" EXACT [] synonym: "skeleton of upper limb" EXACT [FMA:24139] synonym: "upper limb skeleton" EXACT [EHDAA2:0002222] synonym: "wing skeleton" NARROW SENSU [NCBITaxon:8782, OBOL:automatic] xref: AAO:0000202 xref: EHDAA2:0002222 xref: EMAPA:32623 xref: FMA:24142 xref: VHOG:0001256 xref: VSAO:0000151 xref: XAO:0003061 is_a: UBERON:0004381 ! skeleton of limb is_a: UBERON:0007272 ! pectoral appendage skeleton intersection_of: UBERON:0010912 ! subdivision of skeleton intersection_of: RO:0002576 UBERON:0002102 ! skeleton of forelimb relationship: BFO:0000050 UBERON:0012475 ! part of skeleton of pectoral complex relationship: proximally_connected_to UBERON:0007831 ! pectoral girdle skeleton relationship: RO:0002576 UBERON:0002102 ! skeleton of forelimb property_value: IAO:0000116 "TODO - find a home for: FMA:24139 ! skeleton of upper limb" xsd:string [Term] id: UBERON:0001441 name: hindlimb skeleton def: "Subdivision of skeleton consisting of all skeletal elements in an hindlimb region." [https://orcid.org/0000-0002-6601-2165] comment: TOOD - find a home for: FMA:24140 subset: uberon_slim synonym: "bones of lower limb" EXACT [] synonym: "free lower limb skeleton" EXACT [FMA:24144] synonym: "hind limb skeleton" EXACT [XAO:0003062] synonym: "hind-limb skeleton" EXACT [VSAO:0000152] synonym: "hindlimb skeleton" EXACT [VHOG:0001255] synonym: "lower limb skeleton" EXACT [] synonym: "ossa membri inferioris" EXACT OMO:0003011 [FMA:24140, FMA:TA] synonym: "set of bones of lower limb" EXACT [] synonym: "skeleton of free lower limb" EXACT [FMA:24144] synonym: "skeleton of lower limb" EXACT [FMA:24140] xref: AAO:0000217 xref: EHDAA2:0002226 xref: EMAPA:32633 xref: FMA:24144 xref: VHOG:0001255 xref: VSAO:0000152 xref: XAO:0003062 is_a: UBERON:0004381 ! skeleton of limb is_a: UBERON:0007273 ! pelvic appendage skeleton intersection_of: UBERON:0010912 ! subdivision of skeleton intersection_of: RO:0002576 UBERON:0002103 ! skeleton of hindlimb relationship: BFO:0000050 UBERON:0012476 ! part of skeleton of pelvic complex relationship: proximally_connected_to UBERON:0007832 ! pelvic girdle skeleton relationship: RO:0002576 UBERON:0002103 ! skeleton of hindlimb [Term] id: UBERON:0001442 name: skeleton of manus def: "Subdivision of skeleton that is the collection of all skeletal elements in a manus, which is the distal section of the anterior forelimb skeleton consisting of the mesopodium, the metapodium and the acropodium (e.g. including the wrist, palm, and fingers)[Phenoscape]." [https://github.com/obophenotype/uberon/issues/74, https://orcid.org/0000-0002-6601-2165, PHENOSCAPE:MAH] comment: here 'manus' includes both the wrist region, metatarsal region and acropodial region subset: pheno_slim synonym: "anterior autopodium" RELATED [VSAO:0005020, VSAO:NI] synonym: "anterior autopodium skeleton" EXACT [] synonym: "bones of hand" EXACT [FMA:24159] synonym: "fore autopod skeleton" EXACT [] synonym: "forelimb autopod skeleton" EXACT [] synonym: "hand region skeleton" EXACT [EHDAA2:0002227] synonym: "hand skeleton" EXACT [FMA:24159] synonym: "manual skeleton" EXACT [] synonym: "manus" RELATED [VSAO:0005020, VSAO:NI] synonym: "manus skeleton" EXACT [] synonym: "ossa manus" EXACT OMO:0003011 [FMA:24159, FMA:TA] synonym: "set of bones of hand" EXACT [FMA:24159] synonym: "skeleton of hand" EXACT [FMA:24159] xref: EHDAA2:0002227 xref: EMAPA:32643 xref: FMA:24159 xref: VSAO:0005020 is_a: UBERON:0006717 ! autopodial skeleton intersection_of: UBERON:0010912 ! subdivision of skeleton intersection_of: RO:0002576 UBERON:0002398 ! skeleton of manus disjoint_from: UBERON:0001445 {source="lexical"} ! skeleton of pes relationship: BFO:0000050 UBERON:0001440 {source="EHDAA2"} ! part of forelimb skeleton relationship: RO:0002576 UBERON:0002398 ! skeleton of manus property_value: terms:contributor https://orcid.org/0000-0001-9114-8737 property_value: terms:contributor https://orcid.org/0000-0002-6601-2165 [Term] id: UBERON:0001443 name: chest def: "Subdivision of trunk proper, which is demarcated from the neck by the plane of the superior thoracic aperture and from the abdomen internally by the inferior surface of the diaphragm and externally by the costal margin and associated with the thoracic vertebral column and ribcage and from the back of the thorax by the external surface of the posterolateral part of the rib cage, the anterior surface of the thoracic vertebral column and the posterior axillary lines; together with the abdomen and the perineum, it constitutes the trunk proper[FMA]." [FMA:9576, Wikipedia:Chest] subset: efo_slim subset: pheno_slim subset: uberon_slim synonym: "anterolateral part of thorax" EXACT [] synonym: "front of thorax" EXACT [] synonym: "pectus" EXACT OMO:0003011 [FMA:24816, FMA:TA] synonym: "thoracic body wall" RELATED [MA:0000031] synonym: "thorax" RELATED OMO:0003011 [FMA:9576, Wikipedia:Chest] synonym: "ventral part of thoracic region" EXACT [] xref: BTO:0001368 xref: CALOHA:TS-1039 xref: EFO:0000965 xref: EMAPA:37232 {source="MA:th"} xref: EV:0100010 xref: FMA:9576 xref: GAID:91 xref: galen:Chest xref: galen:Thorax xref: MA:0000031 xref: MAT:0000295 xref: MESH:D013909 xref: MIAA:0000295 xref: NCIT:C12799 xref: NCIT:C25389 xref: UMLS:C0817096 {source="ncithesaurus:Thorax"} xref: UMLS:C1527391 {source="ncithesaurus:Chest"} xref: Wikipedia:Chest is_a: UBERON:0009569 {source="FMA-modified"} ! subdivision of trunk relationship: BFO:0000050 UBERON:0000915 {source="FMA", source="MA"} ! part of thoracic segment of trunk property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/d/db/Chest.jpg" xsd:anyURI property_value: IAO:0000116 "FMA:24216 present in FMA1, but gone in subsequent versions" xsd:string [Term] id: UBERON:0001444 name: subdivision of head subset: non_informative synonym: "head region" RELATED [] synonym: "head subdivision" EXACT [] synonym: "region of head" RELATED [] xref: FMA:24218 xref: SCTID:123852005 xref: XAO:0000040 is_a: UBERON:0000475 ! organism subdivision relationship: BFO:0000050 UBERON:0000033 ! part of head property_value: skos:prefLabel "subdivision of head" xsd:string [Term] id: UBERON:0001445 name: skeleton of pes def: "Subdivision of skeleton that is the collection of all skeletal elements in a pes, which is the distal section of the posterior hindlimb skeleton consisting of the mesopodium, the metapodium and the acropodium (e.g. including the ankle, sole, and toes)[Phenoscape]." [https://github.com/obophenotype/uberon/issues/75, https://orcid.org/0000-0002-6601-2165, PHENOSCAPE:MAH] comment: here 'pes' includes both the ankle region, metatarsals and acropodial region subset: pheno_slim synonym: "foot region skeleton" EXACT [EHDAA2:0002228] synonym: "foot skeleton" EXACT [FMA:24222] synonym: "pedal skeleton" EXACT [] synonym: "pes" RELATED INCONSISTENT [VSAO:0005021, VSAO:NI] synonym: "pes skeleton" EXACT [] synonym: "posterior autopodium" RELATED [VSAO:0005021, VSAO:NI] synonym: "posterior autopodium skeleton" EXACT [] synonym: "set of bones of foot" EXACT [FMA:24222] synonym: "skeleton of foot" EXACT [FMA:24222] xref: EHDAA2:0002228 xref: FMA:24222 xref: VSAO:0005021 is_a: UBERON:0006717 ! autopodial skeleton intersection_of: UBERON:0010912 ! subdivision of skeleton intersection_of: RO:0002576 UBERON:0002387 ! skeleton of pes relationship: BFO:0000050 UBERON:0001441 {source="EHDAA2"} ! part of hindlimb skeleton relationship: RO:0002576 UBERON:0002387 ! skeleton of pes property_value: terms:contributor https://orcid.org/0000-0001-9114-8737 property_value: terms:contributor https://orcid.org/0000-0002-6601-2165 [Term] id: UBERON:0001446 name: fibula def: "The major postaxial endochondral bone in the posterior zeugopod[Phenoscape]." [PHENOSCAPE:mah] subset: efo_slim subset: human_reference_atlas subset: pheno_slim subset: uberon_slim xref: AAO:0000891 xref: BTO:0002346 xref: CALOHA:TS-2203 xref: EFO:0003052 xref: EMAPA:19141 xref: FMA:24479 xref: GAID:202 xref: galen:Fibula xref: MA:0001360 xref: MESH:D005360 xref: NCIT:C12718 xref: SCTID:302529003 xref: UMLS:C0016068 {source="ncithesaurus:Fibula"} xref: Wikipedia:Fibula is_a: UBERON:0003608 ! hindlimb long bone is_a: UBERON:0004251 ! hindlimb zeugopod bone is_a: UBERON:0015013 ! fibula endochondral element intersection_of: UBERON:0015013 ! fibula endochondral element intersection_of: RO:0002473 UBERON:0002481 ! composed primarily of bone tissue relationship: BSPO:0001115 UBERON:0010720 ! hindlimb zeugopod skeleton relationship: RO:0002202 UBERON:0010851 ! develops from fibula cartilage element property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/1/16/Illu_lower_extremity.jpg" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001447 name: tarsal bone def: "A bone that is part of the tarsal skeleton. Examples: calcaneus, talus, centralia." [https://orcid.org/0000-0002-6601-2165] subset: pheno_slim subset: uberon_slim synonym: "ankle bone" EXACT [FMA:24491] synonym: "bone of ankle" EXACT [FMA:24491] synonym: "bone of tarsal skeleton" EXACT [http://orcid.org/0000-0002-6601-2165] synonym: "bone of tarsus" EXACT [FMA:24491] synonym: "bony tarsus" RELATED [BTO:0002343] synonym: "hind mesopodium" RELATED [AAO:0000220] synonym: "ossa tarsalia" EXACT OMO:0003004 [FMA:71339, FMA:TA] synonym: "ossa tarsi" EXACT OMO:0003004 [FMA:71339, FMA:TA] synonym: "tarsal" RELATED [BTO:0002343] synonym: "tarsus osseus" RELATED [BTO:0002343] xref: BTO:0002343 xref: EMAPA:25072 xref: FMA:24491 xref: GAID:194 xref: galen:TarsalBone xref: MA:0000297 xref: MESH:D013639 xref: NCIT:C12796 xref: SCTID:108372004 xref: UMLS:C0039316 {source="ncithesaurus:Tarsal_Bone"} is_a: UBERON:0003656 ! mesopodium bone is_a: UBERON:0005899 ! pes bone is_a: UBERON:0015050 ! tarsus endochondral element intersection_of: UBERON:0001474 ! bone element intersection_of: BFO:0000050 UBERON:0004454 ! part of tarsal region disjoint_from: UBERON:0012359 ! pedal digitopodium bone relationship: RO:0002202 UBERON:0010541 ! develops from tarsus cartilage element property_value: foaf:depiction "https://upload.wikimedia.org/wikipedia/commons/b/bf/Ankle_en.svg" xsd:anyURI [Term] id: UBERON:0001448 name: metatarsal bone def: "The metatarsus or metatarsal bones are a group of five long bones in the pes located between the tarsal bones of the hind- and mid-pes and the phalanges of the toes. Lacking individual names, the metatarsal bones are numbered from the medial side (side of big toe): the first, second, third, fourth, and fifth metatarsal. The metatarsals are analogous to the metacarpal bones of the manus. [WP,unvetted]." [Wikipedia:Metatarsal_bone] subset: pheno_slim subset: uberon_slim synonym: "metatarsal" EXACT [] synonym: "ossa metatarsalia" RELATED OMO:0003004 [BTO:0002347] synonym: "ossa metatarsi" RELATED [BTO:0002347] xref: BTO:0002347 xref: EMAPA:32940 xref: EMAPA:36159 xref: FMA:24492 xref: GAID:193 xref: galen:Metatarsal xref: MA:0000303 xref: MESH:D008682 xref: NCIT:C12752 xref: SCTID:302532000 xref: UMLS:C0025584 {source="ncithesaurus:Metatarsal_Bone"} xref: Wikipedia:Metatarsal_bone is_a: UBERON:0003608 ! hindlimb long bone is_a: UBERON:0003821 {is_inferred="true"} ! metapodium bone is_a: UBERON:0012359 ! pedal digitopodium bone is_a: UBERON:0015036 ! pedal digit metatarsal endochondral element intersection_of: UBERON:0001474 ! bone element intersection_of: BFO:0000050 UBERON:0000983 ! part of metatarsus region relationship: BFO:0000050 UBERON:0010545 ! part of metatarsus skeleton relationship: RO:0002170 UBERON:0001447 ! connected to tarsal bone relationship: RO:0002170 UBERON:0001449 ! connected to phalanx of pes property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/5/52/Gray291.png" xsd:anyURI [Term] id: UBERON:0001449 name: phalanx of pes def: "A phalanx that is part of a hindlimb autopod[Automatically generated definition]." [https://orcid.org/0000-0002-6601-2165, Wikipedia:Phalanges_of_the_foot] subset: pheno_slim synonym: "bone of toe" RELATED [FMA:24493] synonym: "digital bone of pes" BROAD [OBOL:automatic] synonym: "digitus pedis phalanx" EXACT [OBOL:automatic] synonym: "foot digit phalanx" EXACT [OBOL:automatic] synonym: "foot phalanx" EXACT [MA:0000305] synonym: "pedal phalanx" EXACT [] synonym: "phalanges of hind digit" RELATED OMO:0003004 [AAO:0000930] synonym: "phalanx of digit of foot" EXACT [OBOL:automatic] synonym: "phalanx of digitus pedis" EXACT [OBOL:automatic] synonym: "phalanx of foot digit" EXACT [OBOL:automatic] synonym: "phalanx of hind digit" EXACT [] synonym: "phalanx of pes" EXACT [] synonym: "phalanx of toe" EXACT [FMA:24493] synonym: "toe phalanx" EXACT [OBOL:automatic] xref: AAO:0000930 xref: EMAPA:32941 xref: FMA:24493 xref: MA:0000305 xref: NCIT:C52772 xref: ncithesaurus:Phalanx_of_the_Foot xref: SCTID:302533005 xref: UMLS:C0584876 {source="ncithesaurus:Foot_Phalanx"} xref: Wikipedia:Phalanges_of_the_foot is_a: UBERON:0003221 ! phalanx is_a: UBERON:0003608 ! hindlimb long bone is_a: UBERON:0004248 ! pedal digit bone is_a: UBERON:0015030 ! pedal digit phalanx endochondral element intersection_of: UBERON:0003221 ! phalanx intersection_of: BFO:0000050 UBERON:0002387 ! part of pes relationship: RO:0002202 UBERON:0010685 ! develops from pedal digit phalanx cartilage element [Term] id: UBERON:0001456 name: face def: "A subdivision of the head that has as parts the layers deep to the surface of the anterior surface, including the mouth, eyes, and nose (when present). In vertebrates, this includes the facial skeleton and structures superficial to the facial skeleton (cheeks, mouth, eyeballs, skin of face, etc)." [http://orcid.org/0000-0002-6601-2165] subset: pheno_slim subset: uberon_slim synonym: "facia/facies" RELATED OMO:0003011 [Wikipedia:Face] synonym: "visage" RELATED [BTO:0003369] xref: BTO:0003369 xref: CALOHA:TS-2216 xref: EMAPA:32763 xref: FMA:24728 xref: GAID:64 xref: galen:Face xref: HAO:0000316 xref: MA:0002473 xref: MESH:D005145 xref: NCIT:C13071 xref: SCTID:302549007 xref: UMLS:C0015450 {source="ncithesaurus:Face"} xref: Wikipedia:Face is_a: UBERON:0001444 ! subdivision of head relationship: RO:0002433 UBERON:0000033 ! contributes to morphology of head property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/5/55/Mona_Lisa_headcrop.jpg" xsd:anyURI property_value: skos:prefLabel "face" xsd:string [Term] id: UBERON:0001457 name: skin of eyelid def: "A zone of skin that is part of a eyelid [Automatically generated definition]." [OBOL:automatic] subset: pheno_slim synonym: "blepharon zone of skin" EXACT [OBOL:automatic] synonym: "eyelid skin" EXACT [] synonym: "eyelid zone of skin" EXACT [OBOL:automatic] synonym: "zone of skin of blepharon" EXACT [OBOL:automatic] synonym: "zone of skin of eyelid" EXACT [OBOL:automatic] xref: EMAPA:37536 {source="MA:th"} xref: FMA:24760 xref: MA:0001256 xref: NCIT:C52718 xref: SCTID:245947005 xref: UMLS:C0222088 {source="ncithesaurus:Eyelid_Skin"} is_a: UBERON:1000021 ! skin of face intersection_of: UBERON:0000014 ! zone of skin intersection_of: BFO:0000050 UBERON:0001711 ! part of eyelid relationship: BFO:0000050 UBERON:0001711 ! part of eyelid [Term] id: UBERON:0001458 name: skin of lip def: "A zone of skin that is part of a lip [Automatically generated definition]." [OBOL:automatic] synonym: "lip skin" EXACT [] synonym: "lip zone of skin" EXACT [OBOL:automatic] synonym: "skin of lips" RELATED OMO:0003004 [] synonym: "zone of skin of lip" EXACT [OBOL:automatic] xref: EMAPA:37643 {source="MA:th"} xref: FMA:24764 xref: MA:0001579 xref: NCIT:C12291 xref: SCTID:244092005 xref: UMLS:C0222101 {source="ncithesaurus:Skin_of_the_Lip"} is_a: UBERON:1000021 ! skin of face intersection_of: UBERON:0000014 ! zone of skin intersection_of: BFO:0000050 UBERON:0001833 ! part of lip relationship: BFO:0000050 UBERON:0001833 ! part of lip property_value: skos:prefLabel "skin of lip" xsd:string [Term] id: UBERON:0001459 name: skin of external ear def: "A zone of skin that is part of a external ear [Automatically generated definition]." [OBOL:automatic] subset: pheno_slim synonym: "auricular region of head zone of skin" EXACT [OBOL:automatic] synonym: "auricular region zone of skin" EXACT [OBOL:automatic] synonym: "ear skin" EXACT [] synonym: "external ear skin" EXACT [] synonym: "external ear zone of skin" EXACT [OBOL:automatic] synonym: "outer ear zone of skin" EXACT [OBOL:automatic] synonym: "zone of skin of auricular region" EXACT [OBOL:automatic] synonym: "zone of skin of auricular region of head" EXACT [OBOL:automatic] synonym: "zone of skin of external ear" EXACT [OBOL:automatic] synonym: "zone of skin of outer ear" EXACT [OBOL:automatic] xref: EMAPA:35301 xref: FMA:24775 xref: MA:0001233 xref: NCIT:C49481 xref: SCTID:244073008 xref: UMLS:C0222110 {source="ncithesaurus:Ear_Skin"} is_a: UBERON:0001084 ! skin of head intersection_of: UBERON:0000014 ! zone of skin intersection_of: BFO:0000050 UBERON:0001691 ! part of external ear relationship: BFO:0000050 UBERON:0001757 ! part of pinna [Term] id: UBERON:0001460 name: arm def: "The part of the forelimb extending from the shoulder to the autopod[cjm]." [Wikipedia:Arm] subset: efo_slim subset: pheno_slim subset: uberon_slim synonym: "brachium" RELATED OMO:0003011 [Wikipedia:Arm] synonym: "upper extremity" RELATED [MESH:A01.378.800] xref: BTO:0001435 xref: CALOHA:TS-2204 xref: EFO:0001410 xref: EHDAA2:0000140 xref: EHDAA:4164 xref: EHDAA:6210 xref: EHDAA:8275 xref: EMAPA:17413 xref: GAID:52 xref: MA:0000033 xref: MESH:D001132 xref: VHOG:0000339 xref: Wikipedia:Arm is_a: UBERON:0006058 ! multi-limb segment region is_a: UBERON:0008785 ! upper limb segment relationship: distally_connected_to UBERON:0002398 ! manus relationship: proximally_connected_to UBERON:0001467 ! shoulder property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/e/ee/Upperarm.jpg" xsd:anyURI property_value: IAO:0000116 "currently declared as overlapping hand, as AOs disagree over whether some wrist parts are in the arm or hand" xsd:string [Term] id: UBERON:0001461 name: elbow def: "The elbow is the region surrounding the elbow-joint-the ginglymus or hinge joint in the middle of the arm. Three bones form the elbow joint: the humerus of the upper arm, and the paired radius and ulna of the forearm. The bony prominence at the very tip of the elbow is the olecranon process of the ulna, and the inner aspect of the elbow is called the antecubital fossa. [WP,unvetted,human-specific]." [Wikipedia:Elbow] subset: efo_slim subset: pheno_slim subset: uberon_slim synonym: "articulatio cubiti" RELATED OMO:0003011 [Wikipedia:Elbow] synonym: "cubital region" EXACT [] synonym: "elbow limb segment" EXACT [] synonym: "elbow region" EXACT [] xref: CALOHA:TS-2222 xref: EFO:0003069 xref: EHDAA2:0000429 xref: EHDAA:4166 xref: EHDAA:6212 xref: EMAPA:17414 xref: FMA:24901 xref: GAID:54 xref: galen:Elbow xref: MA:0000036 xref: MESH:D004550 xref: SCTID:76248009 xref: VHOG:0000340 xref: Wikipedia:Elbow is_a: UBERON:0008785 ! upper limb segment relationship: BFO:0000050 UBERON:0001460 {source="EHDAA2"} ! part of arm property_value: foaf:depiction "https://upload.wikimedia.org/wikipedia/commons/5/5c/Elbow_coude.JPG" xsd:anyURI [Term] id: UBERON:0001464 name: hip def: "The hip region is located lateral to the gluteal region (i.e. the buttock), inferior to the iliac crest, and overlying the greater trochanter of the thigh bone. In adults, three of the bones of the pelvis have fused into the hip bone which forms part of the hip region. The hip joint, scientifically referred to as the acetabulofemoral joint (art. coxae), is the joint between the femur and acetabulum of the pelvis and its primary function is to support the weight of the body in both static (e.g. standing) and dynamic (e.g. walking or running) postures. [WP,modified]." [Wikipedia:Hip] subset: efo_slim subset: pheno_slim subset: uberon_slim synonym: "coxa" RELATED OMO:0003011 [Wikipedia:Hip] synonym: "hip region" EXACT [FMA:24964] synonym: "regio coxae" EXACT [FMA:24964] xref: BTO:0001457 xref: CALOHA:TS-2226 xref: EFO:0001929 xref: EHDAA2:0000783 xref: EHDAA:5153 xref: EHDAA:6178 xref: EMAPA:17490 xref: FMA:24964 xref: GAID:47 xref: galen:Hip xref: MA:0000045 xref: MESH:D006615 xref: NCIT:C64193 xref: SCTID:302543008 xref: UMLS:C0019552 {source="ncithesaurus:Hip"} xref: VHOG:0000346 xref: Wikipedia:Hip is_a: UBERON:0000475 ! organism subdivision relationship: BFO:0000050 UBERON:0010709 ! part of pelvic complex relationship: RO:0002131 UBERON:0001271 {source="FMA-modified"} ! overlaps pelvic girdle region property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/9/9f/Hip.jpg" xsd:anyURI [Term] id: UBERON:0001465 name: knee def: "A segment of the hindlimb that corresponds to the joint connecting a hindlimb stylopod and zeugopod." [https://orcid.org/0000-0002-6601-2165] subset: efo_slim subset: human_reference_atlas subset: pheno_slim subset: uberon_slim synonym: "knee region" EXACT [] xref: BTO:0003595 xref: CALOHA:TS-2220 xref: EHDAA2:0000895 xref: EHDAA:5159 xref: EHDAA:6184 xref: EMAPA:17493 xref: FMA:24974 xref: GAID:48 xref: galen:Knee xref: MA:0000046 xref: MESH:D007717 xref: SCTID:361291001 xref: VHOG:0000347 is_a: UBERON:0008784 ! lower limb segment relationship: BFO:0000050 UBERON:0000978 ! part of leg property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/8/8d/Male_Knee_by_David_Shankbone.jpg" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001466 name: pedal digit def: "A digit that is part of a pes (foot)." [https://orcid.org/0000-0002-6601-2165] subset: pheno_slim subset: uberon_slim synonym: "digit of foot" EXACT [] synonym: "digit of terminal segment of lower limb" EXACT [OBOL:automatic] synonym: "digiti pedis" EXACT OMO:0003004 [FMA:70664, FMA:TA] synonym: "digiti pedis" RELATED OMO:0003011 [Wikipedia:Toe] synonym: "digitipedis" RELATED [BTO:0002348] synonym: "digitus pedis" EXACT [] synonym: "foot digit" EXACT [MA:0000048] synonym: "hind digit" EXACT [XAO:0003035] synonym: "hind_digit" EXACT [AAO:0000888] synonym: "hindlimb digit" EXACT [] synonym: "pedal digit (phalangeal portion) plus soft tissue" EXACT COMPARATIVE_PREFERRED [http://orcid.org/0000-0002-6601-2165] synonym: "pes digit" EXACT [] synonym: "toe" EXACT [FMA:25046] xref: AAO:0000888 xref: BTO:0002348 xref: EMAPA:32649 xref: FMA:25046 xref: GAID:44 xref: galen:Toe xref: MA:0000048 xref: NCIT:C33788 xref: SCTID:116667001 xref: UMLS:C0040357 {source="ncithesaurus:Toe"} xref: Wikipedia:Toe xref: XAO:0003035 is_a: UBERON:0002544 ! digit intersection_of: UBERON:0002544 ! digit intersection_of: BFO:0000050 UBERON:0002387 ! part of pes relationship: BFO:0000050 UBERON:0012142 {source="PHENOSCAPE:ni"} ! part of pedal digitopodium region relationship: BFO:0000050 UBERON:5001466 ! part of pedal digit plus metapodial segment property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/5/5e/Toes.jpg" xsd:anyURI [Term] id: UBERON:0001467 name: shoulder def: "A subdivision of the pectoral complex consisting of the structures in the region of the shoulder joint (which connects the humerus, scapula and clavicle)." [http://orcid.org/0000-0002-6601-2165] subset: efo_slim subset: pheno_slim subset: uberon_slim synonym: "articulatio humeri" RELATED OMO:0003011 [Wikipedia:Shoulder] synonym: "shoulder region" EXACT [] xref: CALOHA:TS-2229 xref: EFO:0003068 xref: EHDAA2:0001834 xref: EHDAA:4180 xref: EHDAA:6228 xref: EMAPA:17421 xref: FMA:25202 xref: GAID:60 xref: galen:Shoulder xref: MA:0000038 xref: MESH:D012782 xref: NCIT:C25203 xref: SCTID:361103004 xref: UMLS:C0037004 {source="ncithesaurus:Shoulder"} xref: VHOG:0000342 xref: Wikipedia:Shoulder is_a: BFO:0000002 is_a: UBERON:0000475 ! organism subdivision relationship: BFO:0000050 UBERON:0010708 ! part of pectoral complex relationship: BFO:0000051 UBERON:0016884 ! has part shoulder joint relationship: RO:0002131 UBERON:0001421 {source="FMA-modified"} ! overlaps pectoral girdle region property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/9/90/Shoulderjoint.PNG" xsd:anyURI [Term] id: UBERON:0001468 name: intervertebral joint def: "The joint between adjacent vertebral bodies. May be composed of the nucleus pulposus, annular ligament, and the anterior and posterior longitudinal ligaments." [http://www.medilexicon.com/medicaldictionary.php?t=87401] synonym: "inter-centrum joint" EXACT [] synonym: "inter-vertebral joint" EXACT [] synonym: "intervertebral symphysis" EXACT [FMA:25511] synonym: "joint of vertebral body" EXACT [FMA:25511] synonym: "vertebral joint" BROAD [] xref: EMAPA:37622 {source="MA:th"} xref: FMA:25511 xref: MA:0001514 xref: NCIT:C49577 xref: SCTID:244512000 xref: UMLS:C1182940 {source="ncithesaurus:Vertebral_Joint"} is_a: UBERON:0002216 {source="FMA"} ! symphysis intersection_of: UBERON:0000982 ! skeletal joint intersection_of: RO:0002176 UBERON:0001075 {cardinality="2"} ! connects bony vertebral centrum relationship: BFO:0000050 UBERON:0001130 {source="FMA"} ! part of vertebral column relationship: RO:0002176 UBERON:0001075 ! connects bony vertebral centrum [Term] id: UBERON:0001469 name: sternoclavicular joint def: "The sternoclavicular articulation is a double arthrodial joint composed of two portions separated by an articular disc. The parts entering into its formation are the sternal end of the clavicle, the upper and lateral part of the manubrium sterni, and the cartilage of the first rib, visible from the outside as the suprasternal notch. The articular surface of the clavicle is much larger than that of the sternum, and is invested with a layer of cartilage, which is considerably thicker than that on the latter bone. The ligaments of this joint are: Articular capsule Anterior sternoclavicular ligament Posterior sternoclavicular ligament Interclavicular ligament Costoclavicular ligament Articular disk [WP,unvetted]." [Wikipedia:Sternoclavicular_articulation] subset: uberon_slim synonym: "articulatio sternoclavicularis" RELATED OMO:0003011 [Wikipedia:Sternoclavicular_articulation] synonym: "sterno clavicular joint" EXACT [] synonym: "sternoclavicular" BROAD [Wikipedia:Sternoclavicular_articulation] synonym: "sternoclavicular articulation" EXACT [Wikipedia:Sternoclavicular_articulation] xref: EMAPA:19203 xref: FMA:25883 xref: GAID:270 xref: MA:0001507 xref: MESH:D013247 xref: NCIT:C33615 xref: SCTID:182165002 xref: UMLS:C0038291 {source="ncithesaurus:Sternoclavicular_Joint"} xref: Wikipedia:Sternoclavicular_articulation is_a: UBERON:0011108 {source="FMA"} ! synovial joint of pectoral girdle intersection_of: UBERON:0000982 ! skeletal joint intersection_of: RO:0002176 UBERON:0000975 ! connects sternum intersection_of: RO:0002176 UBERON:0001105 ! connects clavicle bone relationship: RO:0002176 UBERON:0000975 ! connects sternum relationship: RO:0002176 UBERON:0001105 ! connects clavicle bone property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/3/3f/Gray325.png" xsd:anyURI [Term] id: UBERON:0001470 name: glenohumeral joint def: "The glenohumeral joint, commonly known as the shoulder joint, is a multiaxial synovial ball and socket joint and involves articulation between the glenoid fossa of the scapula (shoulder blade) and the head of the humerus (upper arm bone). [WP,unvetted]." [Wikipedia:Glenohumeral_joint] subset: uberon_slim synonym: "articulatio humeri" EXACT OMO:0003011 [FMA:25912, FMA:TA] synonym: "humeral joint" EXACT [FMA:25912] synonym: "humeroscapular joint" RELATED [Wikipedia:Glenohumeral_joint] synonym: "joint of shoulder" BROAD [OBOL:automatic] synonym: "shoulder joint" BROAD [MA:0000459] xref: EMAPA:19105 xref: FMA:25912 xref: GAID:269 xref: galen:ShoulderJoint xref: MA:0000459 xref: MESH:D012785 xref: NCIT:C33548 xref: SCTID:182168000 xref: UMLS:C0037009 {source="ncithesaurus:Shoulder_Joint"} xref: VHOG:0001002 xref: Wikipedia:Glenohumeral_joint is_a: UBERON:0011108 ! synovial joint of pectoral girdle is_a: UBERON:0011139 {source="FMA"} ! synovial limb joint is_a: UBERON:0016884 ! shoulder joint intersection_of: UBERON:0000982 ! skeletal joint intersection_of: RO:0002176 UBERON:0000976 ! connects humerus intersection_of: RO:0002176 UBERON:0006849 ! connects scapula relationship: BFO:0000050 UBERON:0004753 ! part of scapulocoracoid relationship: RO:0002176 UBERON:0000976 ! connects humerus relationship: RO:0002176 UBERON:0006849 ! connects scapula relationship: RO:0002220 UBERON:0006657 ! adjacent to glenoid fossa property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/a/a3/Gray327.png" xsd:anyURI property_value: IAO:0000116 "note that in this ontology 'glenoid fossa' is a cavity (consistent with FMA) - consider adding a class for the surface of the scapula that is adjacent to this cavity, and making a more explicit connects relationship" xsd:string [Term] id: UBERON:0001471 name: skin of prepuce of penis def: "The loose fold of skin that covers the penis." [MP:0003553, NCBI:matt] subset: pheno_slim synonym: "foreskin of penis" EXACT [] synonym: "penis foreskin" EXACT [] synonym: "preputial skin" EXACT [] xref: FMA:27648 xref: MA:0001744 xref: SCTID:39059001 xref: VHOG:0001342 is_a: UBERON:0001331 ! skin of penis intersection_of: UBERON:0000014 ! zone of skin intersection_of: BFO:0000050 UBERON:0001332 ! part of prepuce of penis relationship: BFO:0000050 UBERON:0001332 ! part of prepuce of penis relationship: RO:0002433 UBERON:0000989 ! contributes to morphology of penis [Term] id: UBERON:0001472 name: vaginal venous plexus def: "The vaginal plexuses are placed at the sides of the vagina; they communicate with the uterine, vesical, and hemorrhoidal plexuses, and are drained by the vaginal veins, one on either side, into the hypogastric veins. [WP,unvetted]." [Wikipedia:Vaginal_venous_plexus] subset: uberon_slim synonym: "plexus venosus vaginalis" RELATED OMO:0003011 [Wikipedia:Vaginal_venous_plexus] synonym: "venous vaginal plexus" EXACT [] xref: EMAPA:37801 {source="MA:th"} xref: FMA:29713 xref: MA:0002257 xref: SCTID:294653003 xref: Wikipedia:Vaginal_venous_plexus is_a: UBERON:0001593 ! venous plexus is_a: UBERON:0006876 ! vasculature of organ intersection_of: UBERON:0001593 ! venous plexus intersection_of: BFO:0000050 UBERON:0000996 ! part of vagina relationship: BFO:0000050 UBERON:0000996 ! part of vagina property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/d/d4/Gray589.png" xsd:anyURI [Term] id: UBERON:0001473 name: lymphatic vessel def: "A vessel that contains or conveys lymph, that originates as an interfibrillar or intercellular cleft or space in a tissue or organ, and that if small has no distinct walls or walls composed only of endothelial cells and if large resembles a vein in structure[BTO]." [BTO:0000752, Wikipedia:Lymphatic_vessel] subset: efo_slim subset: human_reference_atlas subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "lymph vessel" EXACT [] synonym: "vas lymphaticum" RELATED OMO:0003011 [Wikipedia:Lymphatic_vessel] xref: AAO:0011005 xref: BTO:0000752 xref: CALOHA:TS-2102 xref: EFO:0000873 xref: EMAPA:35532 xref: FMA:30315 xref: MA:0000138 xref: MAT:0000443 xref: NCIT:C33038 xref: SCTID:279089004 xref: UMLS:C0229889 {source="ncithesaurus:Lymphatic_Vessel"} xref: VHOG:0001249 xref: Wikipedia:Lymphatic_vessel xref: XAO:0000375 is_a: BFO:0000002 is_a: UBERON:0000055 ! vessel intersection_of: UBERON:0000055 ! vessel intersection_of: BFO:0000050 UBERON:0004536 ! part of lymph vasculature disjoint_from: UBERON:0001981 ! blood vessel relationship: BFO:0000050 UBERON:0004536 ! part of lymph vasculature relationship: BFO:0000051 UBERON:0002391 ! has part lymph relationship: RO:0002433 UBERON:0002405 ! contributes to morphology of immune system property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/4/44/Illu_lymph_capillary.jpg" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001474 name: bone element def: "Skeletal element that is composed of bone tissue." [GO_REF:0000034, http://dx.plos.org/10.1371/journal.pone.0051070, https://github.com/obophenotype/uberon/issues/277, PSPUB:0000170, VSAO:0000057] subset: efo_slim subset: major_organ subset: organ_slim subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "bone" RELATED [AEO:0000082, BTO:0000140, MA:0001459, VHOG:0001190] synonym: "bone organ" EXACT [FMA:5018] synonym: "bones" RELATED OMO:0003004 [ZFA:0001514] xref: AAO:0000047 xref: AEO:0000082 xref: BTO:0000140 xref: CALOHA:TS-0088 xref: EFO:0000298 xref: EHDAA2:0003082 xref: EMAPA:32782 xref: ENVO:00002039 xref: EV:0100140 xref: FMA:30317 xref: FMA:5018 xref: GAID:92 xref: galen:Bone xref: MA:0001459 xref: MAT:0000299 xref: MIAA:0000299 xref: NCIT:C12366 xref: SCTID:90780006 xref: TAO:0001514 xref: UMLS:C0262950 {source="ncithesaurus:Bone"} xref: VHOG:0001190 xref: VSAO:0000057 xref: Wikipedia:Bone xref: XAO:0000169 xref: ZFA:0001514 is_a: BFO:0000002 is_a: UBERON:0004765 ! skeletal element intersection_of: UBERON:0004765 ! skeletal element intersection_of: RO:0002473 UBERON:0002481 ! composed primarily of bone tissue disjoint_from: UBERON:0001630 ! muscle organ disjoint_from: UBERON:0005090 ! muscle structure disjoint_from: UBERON:0010538 ! paired limb/fin segment relationship: RO:0002473 UBERON:0002481 {source="VSAO-modified"} ! composed primarily of bone tissue property_value: skos:prefLabel "bone element" xsd:string [Term] id: UBERON:0001476 name: deltoid def: "A muscle of shoulder which attaches to the scapula, clavicle and humerus.[FMA,generalized]." [FMA:32521, http://orcid.org/0000-0002-6601-2165] comment: We use a generic definition that includes the deltoideus as represented in AAO: 'Muscle which originates as three heads, the pars externalis, pars clavicularis, and pars scapularis. The pars externalis originates from the lateral border of the omosternum and inserts on the distal portion of the humerus. The pars clavicularis originates from the ventro-lateral surface of the clavicle and inserts on the deltoid crest of the humerus. The pars scapularis originates from the lateral surface of the clavicle and inserts on the deltoid crest of the humerus'. Kardong: Dorsal group subset: efo_slim subset: human_reference_atlas subset: pheno_slim subset: uberon_slim synonym: "common shoulder muscle" RELATED [Wikipedia:Deltoid_muscle] synonym: "deltoid muscle" EXACT [Wikipedia:Deltoid_muscle] synonym: "deltoideus" RELATED [Wikipedia:Deltoid_muscle] synonym: "deltoideus muscle" RELATED [Wikipedia:Deltoid_muscle] synonym: "m. deltoideus" EXACT [AAO:0010716] synonym: "musculus deltoideus" EXACT [Wikipedia:Deltoid_muscle] synonym: "musculus deltoideus" RELATED OMO:0003011 [Wikipedia:Deltoid_muscle] xref: AAO:0010716 xref: EFO:0001412 xref: EHDAA2:0000339 xref: EMAPA:18177 xref: FMA:32521 xref: MA:0002286 xref: NCIT:C32446 xref: SCTID:181620007 xref: UMLS:C0224234 {source="ncithesaurus:Deltoid"} xref: VHOG:0000846 xref: Wikipedia:Deltoid_muscle is_a: UBERON:0001482 {source="FMA"} ! muscle of shoulder is_a: UBERON:0034908 ! scapular muscle intersection_of: UBERON:0014892 ! skeletal muscle organ, vertebrate intersection_of: RO:0002371 UBERON:0000976 ! attached to humerus intersection_of: RO:0002371 UBERON:0001105 ! attached to clavicle bone intersection_of: RO:0002371 UBERON:0006849 ! attached to scapula relationship: BFO:0000050 UBERON:0008713 {source="EHDAA2"} ! part of pectoral girdle and thoracic body wall skeletal muscle relationship: RO:0002005 UBERON:0001493 {source="dbpedia"} ! innervated by axillary nerve relationship: RO:0002202 UBERON:0006219 {source="EHDAA2"} ! develops from deltoid pre-muscle mass relationship: RO:0002371 UBERON:0000976 ! attached to humerus relationship: RO:0002372 UBERON:0001105 ! has muscle origin clavicle bone relationship: RO:0002372 UBERON:0002497 ! has muscle origin acromion relationship: RO:0002372 UBERON:0006849 ! has muscle origin scapula relationship: RO:0002373 UBERON:0002498 ! has muscle insertion deltopectoral crest relationship: RO:0002568 UBERON:0001112 {source="dbpedia"} ! has muscle antagonist latissimus dorsi muscle property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/9/93/Deltoideus.png" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001479 name: sesamoid bone def: "A sesamoid element that is composed of bone tissue." [http://orcid.org/0000-0002-6601-2165] comment: Sesamoids are often endochondral replacement elements and in addition to bone tissue, may also be composed of articular cartilage, fibrocartilage, hyaline cartilage, and calcified cartilage.[VSAO] subset: uberon_slim synonym: "ossa sesamoidea" EXACT OMO:0003011 [Wikipedia:Sesamoid_bone] synonym: "sesamoid" BROAD [] xref: AEO:0000086 xref: EHDAA2:0003086 xref: EMAPA:36620 xref: FMA:32672 xref: GAID:210 xref: galen:SessamoidBone xref: MA:0001375 xref: MESH:D012716 xref: NCIT:C33541 xref: SCTID:362914002 xref: UMLS:C0036846 {source="ncithesaurus:Sesamoid_Bone"} xref: Wikipedia:Sesamoid_bone is_a: UBERON:0013630 {source="UBERON:cjm"} ! short bone is_a: UBERON:0013631 ! sesamoid element intersection_of: UBERON:0013631 ! sesamoid element intersection_of: RO:0002473 UBERON:0002481 ! composed primarily of bone tissue property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/b/b3/Gray350.png" xsd:anyURI [Term] id: UBERON:0001480 name: proximal carpal bone def: "A carpal bone that proximally_connected_to a forelimb zeugopod skeleton." [OBOL:automatic] xref: EMAPA:36164 xref: FMA:33302 xref: MA:0002557 xref: SCTID:306715004 is_a: UBERON:0001435 ! carpal bone is_a: UBERON:0014395 ! proximal mesopodial bone is_a: UBERON:0015078 ! proximal carpal endochondral element intersection_of: UBERON:0015078 ! proximal carpal endochondral element intersection_of: RO:0002473 UBERON:0002481 ! composed primarily of bone tissue relationship: RO:0002202 UBERON:0015079 ! develops from proximal carpal cartilage [Term] id: UBERON:0001482 name: muscle of shoulder def: "Any muscle organ that is part of a shoulder [Automatically generated definition]." [OBOL:automatic] subset: human_reference_atlas synonym: "muscle organ of shoulder" EXACT [OBOL:automatic] synonym: "shoulder muscle" EXACT [] synonym: "shoulder muscle organ" EXACT [OBOL:automatic] xref: EMAPA:36154 xref: FMA:33531 xref: MA:0000633 is_a: UBERON:0014892 ! skeletal muscle organ, vertebrate intersection_of: UBERON:0014892 ! skeletal muscle organ, vertebrate intersection_of: RO:0002371 UBERON:0003461 ! attached to shoulder bone relationship: BFO:0000050 UBERON:0004476 {source="prolog"} ! part of musculature of shoulder relationship: RO:0002131 UBERON:0001467 ! overlaps shoulder relationship: RO:0002371 UBERON:0003461 ! attached to shoulder bone property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001483 name: skin of shoulder def: "A zone of skin that is part of a shoulder region." [https://orcid.org/0000-0002-6601-2165, UBERONREF:0000003] synonym: "shoulder skin" EXACT [] synonym: "shoulder zone of skin" EXACT [OBOL:automatic] synonym: "zone of skin of shoulder" EXACT [OBOL:automatic] xref: EMAPA:18059 xref: FMA:34830 xref: MA:0000635 xref: SCTID:244131002 is_a: UBERON:0000014 ! zone of skin intersection_of: UBERON:0000014 ! zone of skin intersection_of: BFO:0000050 UBERON:0001467 ! part of shoulder relationship: BFO:0000050 UBERON:0001467 ! part of shoulder [Term] id: UBERON:0001484 name: articular capsule def: "An articular capsule (or joint capsule) is an envelope surrounding a synovial joint. [WP,unvetted]." [Wikipedia:Articular_capsule] subset: organ_slim subset: uberon_slim synonym: "capsula articularis" EXACT OMO:0003011 [FMA:34836, FMA:TA] synonym: "capsulae articulares" RELATED OMO:0003011 [Wikipedia:Articular_capsule] synonym: "fibrous capsule of joint" EXACT [] synonym: "joint capsule" EXACT [] synonym: "joint fibrous capsule" EXACT [] xref: EMAPA:37621 {source="MA:th"} xref: FMA:34836 xref: GAID:263 xref: galen:JointCapsule xref: MA:0001519 xref: MESH:D017746 xref: NCIT:C32259 xref: NCIT:C84388 xref: SCTID:182238002 xref: UMLS:C0206207 {source="ncithesaurus:Joint_Capsule"} xref: Wikipedia:Articular_capsule is_a: BFO:0000002 is_a: UBERON:0000094 ! membrane organ intersection_of: UBERON:0000094 ! membrane organ intersection_of: BFO:0000051 UBERON:0007616 ! has part layer of synovial tissue intersection_of: RO:0002221 UBERON:0002217 ! surrounds synovial joint relationship: BFO:0000051 UBERON:0007616 ! has part layer of synovial tissue relationship: RO:0002221 UBERON:0002217 ! surrounds synovial joint property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/1/19/Joint.png" xsd:anyURI property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/4/4a/Gray299.png" xsd:anyURI property_value: skos:prefLabel "articular capsule" xsd:string [Term] id: UBERON:0001485 name: knee joint def: "The knee joint joins the thigh with the leg and consists of two articulations: one between the femur and tibia, and one between the femur and patella. It is the largest and most complicated joint in the human body. The knee is a mobile trocho-ginglymus (i.e. a pivotal hinge joint), which permits flexion and extension as well as a slight medial and lateral rotation[WP,unvetted]." [Wikipedia:Knee] subset: efo_slim subset: human_reference_atlas subset: pheno_slim subset: uberon_slim synonym: "articulatio genus" RELATED OMO:0003011 [Wikipedia:Knee] synonym: "joint of knee" EXACT [OBOL:automatic] xref: EFO:0001957 xref: EMAPA:19137 xref: FMA:35175 xref: GAID:114 xref: galen:KneeJoint xref: MA:0000471 xref: MESH:D007719 xref: NCIT:C32898 xref: SCTID:182204005 xref: UMLS:C0022745 {source="ncithesaurus:Knee_Joint"} xref: VHOG:0001003 xref: Wikipedia:Knee is_a: BFO:0000002 is_a: UBERON:0003840 ! hindlimb joint is_a: UBERON:0011139 ! synovial limb joint intersection_of: UBERON:0000982 ! skeletal joint intersection_of: RO:0002176 UBERON:0000979 ! connects tibia intersection_of: RO:0002176 UBERON:0000981 ! connects femur intersection_of: RO:0002176 UBERON:0002446 ! connects patella relationship: BFO:0000050 UBERON:0001465 ! part of knee relationship: RO:0002176 UBERON:0000979 ! connects tibia relationship: RO:0002176 UBERON:0000981 ! connects femur relationship: RO:0002176 UBERON:0002446 ! connects patella relationship: RO:0002202 UBERON:0006256 {evidence="definitional"} ! develops from knee joint primordium property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/c/ca/Knee.agr.jpg" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001487 name: pes joint def: "A skeletal joint that is part of a pes [Automatically generated definition]." [OBOL:automatic] subset: pheno_slim synonym: "articulationes pedis" EXACT OMO:0003011 [FMA:71349, FMA:TA] synonym: "foot joint" EXACT [] synonym: "hind limb autopod joint" EXACT [OBOL:automatic] synonym: "joint of pes" EXACT [] synonym: "joint of terminal segment of free lower limb" EXACT [OBOL:automatic] synonym: "joints of foot" EXACT OMO:0003004 [FMA:71349] synonym: "pedal joint" EXACT [] xref: EMAPA:32949 xref: FMA:35194 xref: GAID:256 xref: MA:0000464 xref: MESH:D033023 xref: SCTID:244555001 xref: Wikipedia:Joints_of_foot is_a: UBERON:0003840 ! hindlimb joint is_a: UBERON:0003841 ! autopod joint is_a: UBERON:0011139 ! synovial limb joint intersection_of: UBERON:0000982 ! skeletal joint intersection_of: BFO:0000050 UBERON:0002387 ! part of pes relationship: BFO:0000050 UBERON:0002387 ! part of pes property_value: IAO:0000116 "TODO check FMA - use the set class for now" xsd:string [Term] id: UBERON:0001488 name: ankle joint def: "A joint that connects the hindlimb autopod and zeugopod skeletons." [https://orcid.org/0000-0002-6601-2165, MESH:A02.835.583.378.062, Wikipedia:Ankle] subset: efo_slim subset: uberon_slim synonym: "gambrel" NARROW [Wikipedia:Hock_(anatomy)] synonym: "hock" NARROW [Wikipedia:Hock_(anatomy)] synonym: "hock joint" NARROW [Wikipedia:Hock_(anatomy)] synonym: "mortise joint" RELATED [BTO:0004706] synonym: "talocrural articulation" RELATED [Wikipedia:Ankle] synonym: "talocrural joint" RELATED [Wikipedia:Ankle] synonym: "talotibial joint" NARROW [Wikipedia:Ankle] xref: BTO:0004706 xref: EMAPA:35126 xref: FMA:35195 xref: GAID:257 xref: galen:AnkleJoint xref: MA:0000463 xref: MESH:D000843 xref: NCIT:C32078 xref: SCTID:182212002 xref: UMLS:C0003087 {source="ncithesaurus:Ankle_Joint"} xref: Wikipedia:Ankle is_a: UBERON:0003840 ! hindlimb joint is_a: UBERON:0011139 ! synovial limb joint intersection_of: UBERON:0000982 ! skeletal joint intersection_of: RO:0002176 UBERON:0001445 ! connects skeleton of pes intersection_of: RO:0002176 UBERON:0010720 ! connects hindlimb zeugopod skeleton relationship: RO:0002131 UBERON:0002387 ! overlaps pes relationship: RO:0002176 UBERON:0001445 ! connects skeleton of pes relationship: RO:0002176 UBERON:0010720 ! connects hindlimb zeugopod skeleton property_value: foaf:depiction "https://upload.wikimedia.org/wikipedia/commons/b/bf/Ankle_en.svg" xsd:anyURI [Term] id: UBERON:0001489 name: manus joint def: "A skeletal joint that is part of a manus (hand) [Automatically generated definition]." [OBOL:automatic] subset: pheno_slim synonym: "articulationes manus" EXACT OMO:0003011 [FMA:71345, FMA:TA] synonym: "hand joint" EXACT [] synonym: "joint of hand" EXACT [] synonym: "joint of manus" EXACT [] synonym: "joint of terminal segment of free upper limb" EXACT [OBOL:automatic] synonym: "manual joint" EXACT [] xref: EMAPA:32641 xref: MA:0000452 xref: SCTID:244546004 xref: Wikipedia:Joints_of_hand is_a: UBERON:0003839 ! forelimb joint is_a: UBERON:0003841 ! autopod joint is_a: UBERON:0011139 ! synovial limb joint intersection_of: UBERON:0000982 ! skeletal joint intersection_of: BFO:0000050 UBERON:0002398 ! part of manus relationship: BFO:0000050 UBERON:0002398 ! part of manus property_value: IAO:0000116 "TODO check FMA - use the set class for now" xsd:string [Term] id: UBERON:0001490 name: elbow joint def: "A joint that connects the forelimb zeugopod and stylopod skeletons[Obol]." [https://orcid.org/0000-0002-6601-2165, Wikipedia:Elbow] subset: pheno_slim subset: uberon_slim synonym: "articulatio cubiti" EXACT OMO:0003011 [] synonym: "cubital region joint" EXACT [OBOL:automatic] synonym: "joint of cubital region" EXACT [OBOL:automatic] synonym: "joint of elbow" EXACT [OBOL:automatic] xref: EMAPA:19102 xref: FMA:35289 xref: GAID:253 xref: galen:ElbowJoint xref: MA:0000451 xref: MESH:D004551 xref: NCIT:C32497 xref: SCTID:182169008 xref: UMLS:C0013770 {source="ncithesaurus:Elbow_Joint"} xref: VHOG:0000997 xref: Wikipedia:Elbow is_a: BFO:0000002 is_a: UBERON:0003839 ! forelimb joint is_a: UBERON:0011139 ! synovial limb joint intersection_of: UBERON:0000982 ! skeletal joint intersection_of: RO:0002176 UBERON:0000976 ! connects humerus intersection_of: RO:0002176 UBERON:0010703 ! connects forelimb zeugopod skeleton relationship: BFO:0000050 UBERON:0001461 ! part of elbow relationship: RO:0002176 UBERON:0000976 ! connects humerus relationship: RO:0002176 UBERON:0010703 ! connects forelimb zeugopod skeleton relationship: RO:0002202 UBERON:0006224 {evidence="definitional"} ! develops from elbow joint primordium [Term] id: UBERON:0001491 name: wrist joint def: "A joint connecting the forelimb zeugopod skeleton with the carpal skeleton." [https://orcid.org/0000-0002-6601-2165, https://sourceforge.net/tracker/?group_id=76834&atid=1205376, Wikipedia:Wrist] subset: uberon_slim synonym: "carpal region joint" EXACT [OBOL:automatic] synonym: "joint of carpal region" EXACT [OBOL:automatic] synonym: "joint of wrist" EXACT [] synonym: "radiocarpal joint" NARROW INCONSISTENT [FMA:35291] xref: FMA:321842 xref: GAID:274 xref: galen:WristJoint xref: MA:0000460 xref: MESH:D014955 xref: NCIT:C33894 xref: SCTID:182178002 xref: UMLS:C1322271 {source="ncithesaurus:Wrist_Joint"} xref: Wikipedia:Wrist is_a: UBERON:0001489 ! manus joint intersection_of: UBERON:0000982 ! skeletal joint intersection_of: RO:0002176 UBERON:0009880 ! connects carpal skeleton intersection_of: RO:0002176 UBERON:0010703 ! connects forelimb zeugopod skeleton relationship: BFO:0000050 UBERON:0004452 ! part of carpal region relationship: RO:0002176 UBERON:0009880 ! connects carpal skeleton relationship: RO:0002176 UBERON:0010703 ! connects forelimb zeugopod skeleton property_value: foaf:depiction "https://upload.wikimedia.org/wikipedia/commons/4/4a/Human_wrist.png" xsd:anyURI [Term] id: UBERON:0001493 name: axillary nerve def: "The axillary nerve is a nerve of the human body, that comes off the posterior cord of the brachial plexus at the level of the axilla (armpit) and carries nerve fibers from C5 and C6. The axillary nerve travels through the quadrangular space with the posterior circumflex humeral artery and vein. [WP,unvetted]." [Wikipedia:Axillary_nerve] subset: human_reference_atlas subset: uberon_slim synonym: "auxillery nerve" RELATED [Wikipedia:Axillary_nerve] synonym: "circumflex humeral nerve" EXACT [] synonym: "circumflex nerve" RELATED [Wikipedia:Axillary_nerve] synonym: "nervus axillaris" RELATED OMO:0003011 [Wikipedia:Axillary_nerve] xref: EMAPA:18802 xref: FMA:37072 xref: MA:0001166 xref: NCIT:C52817 xref: SCTID:181009006 xref: UMLS:C0228885 {source="ncithesaurus:Axillary_Nerve"} xref: Wikipedia:Axillary_nerve is_a: UBERON:0003433 ! arm nerve relationship: BFO:0000050 UBERON:0001814 {source="MA"} ! part of brachial nerve plexus relationship: RO:0002134 UBERON:0009472 ! innervates axilla property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/e/ea/Brachial_plexus_2.svg" xsd:anyURI property_value: foaf:depiction "https://upload.wikimedia.org/wikipedia/commons/d/d4/Brachial_plexus.jpg" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001495 name: pectoral muscle def: "Muscles of the upper chest. The term may refer to one of two muscles, the pectoralis major and pectoralis minor. The former is a thick muscle in the anterior portion of the chest. Its action involves flexion, medial rotation, and adduction of the humerus. The latter is a thin muscle located beneath the pectoralis major. Its action involves lowering the scapula and raising the ribs." [ncithesaurus:Pectoralis_Muscle] comment: This currently groups the major and minor muscles (which have different attachment sites) as well as the AAO structure: Muscle which is comprised of three heads. The anterior head is the portio epicoracoidea that originates on the epicoracoid cartilage and inserts on the deltoid crest of the humerus. The next more posterior head, portio sternalis, originates on the sternum and inserts in the groove next to the deltoid crest of the humerus. The most posterior head, portio abdominalis, arises from the M. rectus abdominis and inserts on the deltoid crest of the humerus subset: grouping_class subset: human_reference_atlas subset: pheno_slim subset: uberon_slim synonym: "breast muscle" RELATED [BTO:0000023] synonym: "M. pectoralis" EXACT [AAO:0010727] synonym: "muscle of pectoral part of chest" EXACT [FMA:37349] synonym: "muscle of pectoral region" EXACT [FMA:37349] synonym: "pectoralis" RELATED [] synonym: "pectoralis group muscle" RELATED [] synonym: "pectoralis muscle" RELATED [BTO:0000023] xref: AAO:0010727 xref: BTO:0000023 xref: CALOHA:TS-0751 xref: EMAPA:35670 xref: FMA:37349 xref: GAID:153 xref: MA:0002423 xref: MESH:D010369 xref: NCIT:C33286 xref: SCTID:181621006 xref: UMLS:C0030747 {source="ncithesaurus:Pectoralis_Muscle"} is_a: UBERON:0003830 ! thoracic segment muscle is_a: UBERON:0008196 {source="FMA"} ! muscle of pectoral girdle relationship: RO:0002202 UBERON:0010984 ! develops from pectoral pre-muscle mass property_value: foaf:depiction "https://upload.wikimedia.org/wikipedia/commons/6/6c/Pectoralis_major.png" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001496 name: ascending aorta def: "The ascending aorta is the portion of the aorta in a two-pass circulatory system that lies between the heart and the arch of aorta[GO]. A portion of the aorta commencing at the upper part of the base of the left ventricle, on a level with the lower border of the third costal cartilage behind the left half of the sternum; it passes obliquely upward, forward, and to the right, in the direction of the heart's axis, as high as the upper border of the second right costal cartilage, describing a slight curve in its course, and being situated, about 6 cm behind the posterior surface of the sternum. The total length is about 5 cm in length [Wikipedia]." [GO:0035905, Wikipedia:Ascending_aorta] subset: human_reference_atlas subset: pheno_slim subset: uberon_slim synonym: "aorta ascendens" RELATED OMO:0003011 [Wikipedia:Ascending_aorta] synonym: "ascending thoracic aorta" EXACT [EMAPA:17014] synonym: "pars ascendens aortae" EXACT [] synonym: "pars ascendens aortae" RELATED OMO:0003011 [Wikipedia:Ascending_aorta] xref: EHDAA2:0000147 xref: EHDAA:9828 xref: EMAPA:17014 xref: FMA:3736 xref: MA:0002570 xref: NCIT:C32150 xref: SCTID:181299009 xref: UMLS:C0003956 {source="ncithesaurus:Ascending_Aorta"} xref: Wikipedia:Ascending_aorta is_a: BFO:0000002 is_a: UBERON:0001515 ! thoracic aorta relationship: BFO:0000050 UBERON:0001515 ! part of thoracic aorta relationship: RO:0002202 UBERON:0005338 {source="EHDAA2"} ! develops from outflow tract aortic component relationship: RO:0002254 UBERON:0002061 ! has developmental contribution from truncus arteriosus relationship: RO:0002254 UBERON:0005432 ! has developmental contribution from aortic sac relationship: RO:0002433 UBERON:0001515 ! contributes to morphology of thoracic aorta property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/e/e6/Gray506.svg" xsd:anyURI property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/blood-vasculature-female/v1.3/assets/3d-vh-f-blood-vasculature.glb" xsd:anyURI property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/blood-vasculature-male/v1.3/assets/3d-vh-m-blood-vasculature.glb" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "ascending aorta" xsd:string [Term] id: UBERON:0001497 name: muscle of pelvic girdle def: "Any muscle organ that is part of a pelvic girdle [Automatically generated definition]." [OBOL:automatic] subset: pheno_slim synonym: "girdle-pelvic muscle organ" EXACT [OBOL:automatic] synonym: "muscle organ of girdle-pelvic" EXACT [OBOL:automatic] synonym: "muscle organ of pelvic girdle" EXACT [OBOL:automatic] synonym: "muscle organ of pelvic girdle bone" EXACT [OBOL:automatic] synonym: "pelvic girdle muscle" EXACT [] synonym: "pelvic girdle muscle organ" EXACT [OBOL:automatic] synonym: "pelvic girdle skeletal muscle" EXACT [EMAPA:18185] xref: EHDAA:8326 xref: EMAPA:18185 xref: FMA:37367 xref: MA:0000537 xref: RETIRED_EHDAA2:0001430 is_a: UBERON:0001325 ! muscle of pelvis is_a: UBERON:0010890 ! pelvic complex muscle intersection_of: UBERON:0014892 ! skeletal muscle organ, vertebrate intersection_of: BFO:0000050 UBERON:0001271 ! part of pelvic girdle region relationship: BFO:0000050 UBERON:0004470 {source="https://github.com/obophenotype/uberon/wiki/Inferring-part-of-relationships"} ! part of musculature of pelvic girdle [Term] id: UBERON:0001498 name: muscle of pes def: "Any muscle organ that is part of a pes [Automatically generated definition]." [OBOL:automatic] synonym: "foot muscle" EXACT [] synonym: "foot muscle organ" EXACT [OBOL:automatic] synonym: "muscle of foot" EXACT [FMA:37369] synonym: "muscle organ of foot" EXACT [OBOL:automatic] xref: BTO:0000477 xref: EMAPA:36160 xref: FMA:37369 xref: MA:0000652 xref: SCTID:67240005 is_a: UBERON:0003663 ! hindlimb muscle intersection_of: UBERON:0014892 ! skeletal muscle organ, vertebrate intersection_of: BFO:0000050 UBERON:0002387 ! part of pes relationship: BFO:0000050 UBERON:0004488 {source="prolog"} ! part of musculature of pes [Term] id: UBERON:0001499 name: muscle of arm def: "A muscle organ that is part of an arm [Automatically generated definition]." [OBOL:automatic] subset: human_reference_atlas subset: pheno_slim synonym: "arm muscle" EXACT [MA:0000594] synonym: "arm muscle system" RELATED [EHDAA2:0000141] synonym: "arm skeletal muscle" EXACT [OBOL:automatic] synonym: "arm skeletal muscle tissue" EXACT [OBOL:automatic] synonym: "muscle of upper arm or lower arm" EXACT [https://orcid.org/0000-0002-6601-2165] synonym: "upper arm / lower arm muscle" EXACT [https://orcid.org/0000-0002-6601-2165] xref: EHDAA:8277 xref: EMAPA:36053 xref: MA:0000594 xref: RETIRED_EHDAA2:0000142 is_a: UBERON:0003662 ! forelimb muscle intersection_of: UBERON:0014892 ! skeletal muscle organ, vertebrate intersection_of: BFO:0000050 UBERON:0001460 ! part of arm relationship: BFO:0000050 UBERON:0004474 {source="https://github.com/obophenotype/uberon/wiki/Inferring-part-of-relationships"} ! part of musculature of arm property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001500 name: muscle of manus def: "Any muscle organ that is part of a manus [Automatically generated definition]." [OBOL:automatic] subset: human_reference_atlas synonym: "hand muscle" EXACT [MA:0000628] synonym: "manus muscle" EXACT [] synonym: "manus muscle organ" EXACT [OBOL:automatic] synonym: "muscle of hand" EXACT [FMA:37372] synonym: "muscle organ of manus" EXACT [OBOL:automatic] xref: EMAPA:32644 xref: FMA:37372 xref: MA:0000628 xref: SCTID:110540008 is_a: UBERON:0003662 ! forelimb muscle intersection_of: UBERON:0014892 ! skeletal muscle organ, vertebrate intersection_of: BFO:0000050 UBERON:0002398 ! part of manus relationship: BFO:0000050 UBERON:0004489 {source="prolog"} ! part of musculature of manus property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001508 name: arch of aorta def: "The convex portion of the aorta between the ascending and descending parts of the aorta; branches from it include the brachiocephalic trunk, the left common carotid artery, and the left subclavian artery; the brachiocephalic trunk further splits to form the right subclavian artery and the right common carotid artery." [ISBN:0-683-40008-8, MP:0004113] subset: human_reference_atlas subset: pheno_slim subset: uberon_slim synonym: "aortic arch" RELATED [FMA:3768] synonym: "arcus aortae" EXACT OMO:0003011 [FMA:3768, FMA:TA] synonym: "thoracic aorta" RELATED [GAID:471] xref: BTO:0000157 xref: EFO:0002526 xref: EHDAA2:0000132 xref: EMAPA:17613 xref: FMA:3768 xref: GAID:471 xref: MA:0000475 xref: SCTID:181300001 xref: VHOG:0001196 xref: Wikipedia:Arch_of_aorta is_a: BFO:0000002 is_a: UBERON:0001515 ! thoracic aorta relationship: BFO:0000050 UBERON:0001515 ! part of thoracic aorta relationship: RO:0002170 UBERON:0001496 ! connected to ascending aorta relationship: RO:0002202 UBERON:0003121 ! develops from pharyngeal arch artery 4 relationship: RO:0002254 UBERON:0005432 ! has developmental contribution from aortic sac relationship: RO:0002254 UBERON:0005613 ! has developmental contribution from left dorsal aorta relationship: RO:0002433 UBERON:0001515 ! contributes to morphology of thoracic aorta property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/e/e6/Gray506.svg" xsd:anyURI property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/blood-vasculature-female/v1.3/assets/3d-vh-f-blood-vasculature.glb" xsd:anyURI property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/blood-vasculature-male/v1.3/assets/3d-vh-m-blood-vasculature.glb" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "arch of aorta" xsd:string [Term] id: UBERON:0001510 name: skin of knee def: "A zone of skin that is part of a knee [Automatically generated definition]." [OBOL:automatic] synonym: "knee skin" EXACT [] synonym: "knee zone of skin" EXACT [OBOL:automatic] synonym: "zone of skin of knee" EXACT [OBOL:automatic] xref: EMAPA:18151 xref: FMA:37800 xref: MA:0000668 xref: NCIT:C64859 xref: SCTID:181552001 xref: UMLS:C0222275 {source="ncithesaurus:Knee_Skin"} is_a: UBERON:0001511 ! skin of leg intersection_of: UBERON:0000014 ! zone of skin intersection_of: BFO:0000050 UBERON:0001465 ! part of knee relationship: BFO:0000050 UBERON:0001465 ! part of knee [Term] id: UBERON:0001511 name: skin of leg def: "A zone of skin that is part of a leg [Automatically generated definition]." [OBOL:automatic] synonym: "leg skin" EXACT [] synonym: "leg zone of skin" EXACT [OBOL:automatic] synonym: "zone of skin of leg" EXACT [OBOL:automatic] xref: EMAPA:37352 {source="MA:th"} xref: FMA:37828 xref: MA:0000674 xref: NCIT:C52749 xref: UMLS:C0222279 {source="ncithesaurus:Leg_Skin"} is_a: UBERON:0003532 ! hindlimb skin intersection_of: UBERON:0000014 ! zone of skin intersection_of: BFO:0000050 UBERON:0000978 ! part of leg relationship: BFO:0000050 UBERON:0000978 ! part of leg [Term] id: UBERON:0001512 name: skin of ankle def: "A zone of skin that is part of an ankle [Automatically generated definition]." [OBOL:automatic] synonym: "ankle skin" EXACT [] synonym: "ankle zone of skin" EXACT [OBOL:automatic] synonym: "tarsal region skin" EXACT [https://orcid.org/0000-0002-6601-2165] synonym: "zone of skin of ankle" EXACT [OBOL:automatic] xref: EMAPA:37353 {source="MA:th"} xref: FMA:37831 xref: MA:0000641 xref: NCIT:C52751 xref: SCTID:181560000 xref: UMLS:C0222286 {source="ncithesaurus:Ankle_Skin"} is_a: UBERON:0001513 ! skin of pes intersection_of: UBERON:0000014 ! zone of skin intersection_of: BFO:0000050 UBERON:0004454 ! part of tarsal region relationship: BFO:0000050 UBERON:0004454 ! part of tarsal region [Term] id: UBERON:0001513 name: skin of pes def: "A zone of skin that is part of a pes [Automatically generated definition]." [OBOL:automatic] subset: pheno_slim synonym: "foot skin" EXACT [] synonym: "skin of foot" EXACT [FMA:37834] synonym: "skin of hind-paw" NARROW SENSU [EMAPA:18504] xref: EMAPA:18504 xref: FMA:37834 xref: MA:0000654 xref: NCIT:C52750 xref: SCTID:181529000 xref: UMLS:C0222289 {source="ncithesaurus:Foot_Skin"} is_a: UBERON:0003532 {source="MA"} ! hindlimb skin is_a: UBERON:0015790 ! autopod skin intersection_of: UBERON:0000014 ! zone of skin intersection_of: BFO:0000050 UBERON:0002387 ! part of pes relationship: BFO:0000050 UBERON:0002387 ! part of pes [Term] id: UBERON:0001514 name: descending aorta def: "The descending aorta is the portion of the aorta in a two-pass circulatory system from the arch of aorta to the point where it divides into the common iliac arteries[GO]. The descending aorta is part of the aorta, the largest artery in the body. The descending aorta is the part of the aorta beginning at the aortic arch that runs down through the chest and abdomen. The descending aorta is divided into two portions, the thoracic and abdominal, in correspondence with the two great cavities of the trunk in which it is situated. Within the abdomen, the descending aorta branches into the two common iliac arteries which serve the legs. [WP,unvetted]." [GO:0035906, Wikipedia:Descending_aorta] subset: human_reference_atlas subset: pheno_slim subset: uberon_slim synonym: "aorta descendens" RELATED OMO:0003011 [Wikipedia:Descending_aorta] synonym: "pars descendens aortae" EXACT [FMA:3784] synonym: "pars descendens aortae" RELATED OMO:0003011 [Wikipedia:Descending_aorta] xref: EMAPA:18606 xref: FMA:3784 xref: MA:0002571 xref: NCIT:C32455 xref: SCTID:261399002 xref: UMLS:C0011666 {source="ncithesaurus:Descending_Aorta"} xref: Wikipedia:Descending_aorta is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0005800 {source="FMA"} ! section of aorta relationship: RO:0002170 UBERON:0001508 ! connected to arch of aorta relationship: RO:0002202 UBERON:0005805 {source="Wikipedia"} ! develops from dorsal aorta relationship: RO:0002254 UBERON:0005613 ! has developmental contribution from left dorsal aorta relationship: RO:0002254 UBERON:0005622 ! has developmental contribution from right dorsal aorta property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/e/e6/Gray506.svg" xsd:anyURI property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/blood-vasculature-female/v1.3/assets/3d-vh-f-blood-vasculature.glb" xsd:anyURI property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/blood-vasculature-male/v1.3/assets/3d-vh-m-blood-vasculature.glb" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "descending aorta" xsd:string [Term] id: UBERON:0001515 name: thoracic aorta def: "The part of the aorta that extends from the origin at the heart to the diaphragm, and from which arises numerous branches that supply oxygenated blood to the chest cage and the organs within the chest." [http://www.medterms.com, MP:0010468] subset: efo_slim subset: pheno_slim subset: uberon_slim synonym: "aorta thoracalis" RELATED OMO:0003011 [Wikipedia:Thoracic_aorta] synonym: "aorta thoracica" EXACT OMO:0003011 [FMA:3786, FMA:TA] synonym: "pars thoracica aortae" RELATED OMO:0003011 [Wikipedia:Thoracic_aorta] synonym: "thoracic part of aorta" EXACT [] xref: BTO:0000157 xref: EFO:0002525 xref: EMAPA:18603 xref: FMA:3786 xref: GAID:471 xref: galen:ThoracicAorta xref: MA:0002569 xref: MESH:D001013 xref: NCIT:C33766 xref: SCTID:302510009 xref: UMLS:C1522460 {source="ncithesaurus:Thoracic_Aorta"} xref: Wikipedia:Thoracic_aorta is_a: UBERON:0005800 {source="FMA"} ! section of aorta intersection_of: UBERON:0005800 ! section of aorta intersection_of: BFO:0000050 UBERON:0000915 ! part of thoracic segment of trunk relationship: BFO:0000050 UBERON:0000915 ! part of thoracic segment of trunk relationship: RO:0002433 UBERON:0000947 ! contributes to morphology of aorta property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/7/75/Gray530.png" xsd:anyURI property_value: skos:prefLabel "thoracic aorta" xsd:string [Term] id: UBERON:0001516 name: abdominal aorta def: "Abdominal part of aorta: the distal part of the descending aorta, which is the continuation of the thoracic part and gives rise to the inferior phrenic, lumbar, median sacral, superior and inferior mesenteric, middle suprarenal, renal, and testicular or ovarian arteries, and celiac trunk[BTO]. The abdominal aorta is the largest artery in the abdominal cavity. As part of the aorta, it is a direct continuation of descending aorta(of the thorax). [WP,unvetted]." [BTO:0002976, Wikipedia:Abdominal_aorta] subset: efo_slim subset: human_reference_atlas subset: pheno_slim subset: uberon_slim synonym: "abdominal part of aorta" EXACT [FMA:3789] synonym: "abdominal part of aorta" RELATED [BTO:0002976] synonym: "aorta abdominalis" RELATED OMO:0003011 [BTO:0002976, Wikipedia:Abdominal_aorta] synonym: "descending abdominal aorta" EXACT [FMA:3789] synonym: "pars abdominalis aortae" EXACT [FMA:3789] synonym: "pars abdominalis aortae" RELATED OMO:0003011 [BTO:0002976, Wikipedia:Abdominal_aorta] xref: BTO:0002976 xref: EFO:0002524 xref: EMAPA:17856 xref: FMA:3789 xref: GAID:470 xref: galen:AbdominalAorta xref: MA:0000474 xref: MESH:D001012 xref: NCIT:C32038 xref: SCTID:244231007 xref: UMLS:C0003484 {source="ncithesaurus:Abdominal_Aorta"} xref: Wikipedia:Abdominal_aorta is_a: UBERON:0005800 ! section of aorta relationship: BFO:0000050 UBERON:0001514 {source="FMA"} ! part of descending aorta relationship: RO:0002131 UBERON:0000916 ! overlaps abdomen relationship: RO:0002170 UBERON:0002345 ! connected to descending thoracic aorta relationship: RO:0002433 UBERON:0001514 ! contributes to morphology of descending aorta property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/a/af/Gray531.png" xsd:anyURI property_value: IAO:0000116 "Many of the branches of the abdominal aorta in mammals may be branches of the dorsal aorta in other vertebrates" xsd:string property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "abdominal aorta" xsd:string [Term] id: UBERON:0001517 name: skin of elbow def: "A zone of skin that is part of a elbow [Automatically generated definition]." [OBOL:automatic] synonym: "cubital region zone of skin" EXACT [OBOL:automatic] synonym: "elbow skin" EXACT [] synonym: "elbow zone of skin" EXACT [OBOL:automatic] synonym: "zone of skin of cubital region" EXACT [OBOL:automatic] synonym: "zone of skin of elbow" EXACT [OBOL:automatic] xref: EMAPA:18051 xref: FMA:38250 xref: MA:0000610 xref: NCIT:C52755 xref: SCTID:181534001 xref: UMLS:C0222213 {source="ncithesaurus:Elbow_Skin"} is_a: UBERON:0002427 ! arm skin intersection_of: UBERON:0000014 ! zone of skin intersection_of: BFO:0000050 UBERON:0001461 ! part of elbow relationship: BFO:0000050 UBERON:0001461 ! part of elbow [Term] id: UBERON:0001518 name: skin of wrist def: "A zone of skin that is part of a wrist [Automatically generated definition]." [OBOL:automatic] synonym: "carpal region zone of skin" EXACT [OBOL:automatic] synonym: "wrist skin" EXACT [] synonym: "wrist zone of skin" EXACT [OBOL:automatic] synonym: "zone of skin of carpal region" EXACT [OBOL:automatic] synonym: "zone of skin of wrist" EXACT [OBOL:automatic] xref: EMAPA:37351 {source="MA:th"} xref: FMA:38280 xref: MA:0000638 xref: NCIT:C52752 xref: SCTID:181540008 xref: UMLS:C0222223 {source="ncithesaurus:Wrist_Skin"} is_a: UBERON:0001519 ! skin of manus intersection_of: UBERON:0000014 ! zone of skin intersection_of: BFO:0000050 UBERON:0004452 ! part of carpal region relationship: BFO:0000050 UBERON:0004452 ! part of carpal region [Term] id: UBERON:0001519 name: skin of manus def: "A zone of skin that is part of a manus [Automatically generated definition]." [OBOL:automatic] subset: pheno_slim synonym: "hand skin" EXACT [MA:0000630] synonym: "manus skin" EXACT [] synonym: "skin of fore-paw" NARROW SENSU [EMAPA:18486] synonym: "skin of hand" EXACT [FMA:38295] xref: EMAPA:18486 xref: FMA:38295 xref: MA:0000630 xref: NCIT:C52753 xref: SCTID:181527003 xref: UMLS:C0222224 {source="ncithesaurus:Hand_Skin"} is_a: UBERON:0003531 ! forelimb skin is_a: UBERON:0015790 ! autopod skin intersection_of: UBERON:0000014 ! zone of skin intersection_of: BFO:0000050 UBERON:0002398 ! part of manus relationship: BFO:0000050 UBERON:0002398 ! part of manus [Term] id: UBERON:0001529 name: brachiocephalic artery def: "The short first aortic arch branch and divides into the right subclavian artery and the right common carotid artery." [MGI:csmith, MP:0010663] subset: efo_slim subset: human_reference_atlas subset: pheno_slim subset: uberon_slim synonym: "brachiocephalic trunk" EXACT [MA:0001922] synonym: "innominate" BROAD [Wikipedia:Brachiocephalic_artery] synonym: "innominate artery" EXACT [Wikipedia:Brachiocephalic_artery] synonym: "truncus brachiocephalicus" EXACT OMO:0003011 [FMA:3932, FMA:TA] synonym: "truncus brachiocephalicus" RELATED OMO:0003011 [Wikipedia:Brachiocephalic_artery] xref: EFO:0002550 xref: EHDAA2:0000835 xref: EMAPA:17615 xref: FMA:3932 xref: GAID:476 xref: galen:BrachioCephalicArtery xref: MA:0001922 xref: MESH:D016122 xref: NCIT:C32814 xref: SCTID:244244002 xref: UMLS:C0006094 {source="ncithesaurus:Innominate_Artery"} xref: Wikipedia:Brachiocephalic_artery is_a: UBERON:0004573 ! systemic artery relationship: BFO:0000050 UBERON:0007204 ! part of brachiocephalic vasculature relationship: channels_from UBERON:0001508 ! arch of aorta relationship: RO:0002170 UBERON:0001508 ! connected to arch of aorta property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/e/e6/Gray506.svg" xsd:anyURI property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/blood-vasculature-female/v1.3/assets/3d-vh-f-blood-vasculature.glb" xsd:anyURI property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/blood-vasculature-male/v1.3/assets/3d-vh-m-blood-vasculature.glb" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "brachiocephalic artery" xsd:string [Term] id: UBERON:0001530 name: common carotid artery plus branches def: "A bilaterally paired branched artery that originates from the aortic arches and divides into and includes as parts the internal and external carotid arteries[cjm]." [Wikipedia:Common_carotid_artery] subset: human_reference_atlas subset: pheno_slim subset: uberon_slim synonym: "a. carotis communis" RELATED OMO:0003011 [Wikipedia:Common_carotid_artery] synonym: "carotid artery" BROAD [FMA:3939] synonym: "carotid artery system" EXACT [EHDAA2:0000217] synonym: "common carotid artery" EXACT INCONSISTENT [FMA:3939] synonym: "trunk of common carotid tree" EXACT [FMA:3939] xref: CALOHA:TS-0116 xref: EHDAA2:0000217 xref: EHDAA:7331 xref: EMAPA:17855 xref: FMA:3939 xref: GAID:479 xref: MA:0001926 xref: MESH:D017536 xref: NCIT:C32352 xref: SCTID:362041005 xref: UMLS:C0162859 {source="ncithesaurus:Common_Carotid_Artery"} xref: VHOG:0000272 xref: Wikipedia:Common_carotid_artery is_a: UBERON:0004573 {source="FMA"} ! systemic artery relationship: RO:0002170 UBERON:0001508 ! connected to arch of aorta relationship: RO:0002202 UBERON:0004363 {source="Wikipedia"} ! develops from pharyngeal arch artery relationship: RO:0002488 UBERON:0000068 ! existence starts during embryo stage property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/e/e6/Gray506.svg" xsd:anyURI property_value: IAO:0000116 "we follow the FMA and treat the artery as a tree-structure - here we include the internal and external as parts. For the part that excludes the branches, see 'trunk of common carotid artery'" xsd:string property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "common carotid artery plus branches" xsd:string [Term] id: UBERON:0001531 name: right common carotid artery plus branches def: "The rightmost of the two common carotid arteries, originating from in the neck from the brachiocephalic trunk." [UBERON:cjm] subset: human_reference_atlas subset: uberon_slim synonym: "right common carotid artery" EXACT [MA:0001928] synonym: "right common carotid artery" RELATED [FMA:3941] synonym: "trunk of right common carotid tree" EXACT [FMA:3941] xref: EMAPA:35749 xref: FMA:3941 xref: MA:0001928 xref: NCIT:C33473 xref: SCTID:362042003 xref: UMLS:C0226086 {source="ncithesaurus:Right_Common_Carotid_Artery"} xref: Wikipedia:Right_common_carotid_artery is_a: UBERON:0001530 {source="FMA"} ! common carotid artery plus branches relationship: RO:0002170 UBERON:0001529 ! connected to brachiocephalic artery property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/e/e6/Gray506.svg" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "right common carotid artery plus branches" xsd:string [Term] id: UBERON:0001532 name: internal carotid artery def: "A terminal branch of the left or right common carotid artery which supplies oxygenated blood to the brain and eyes[MP]." [MGI:anna] subset: efo_slim subset: human_reference_atlas subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "arteria carotis interna" RELATED OMO:0003011 [Wikipedia:Internal_carotid_artery] synonym: "cranial carotid artery" EXACT [ZFA:0005081] synonym: "ICA" RELATED OMO:0003000 [] synonym: "internal carotid" EXACT [AAO:0010219] xref: AAO:0010219 xref: AAO:0011054 xref: BTO:0004697 xref: EFO:0001952 xref: EHDAA2:0000873 xref: EHDAA:408 xref: EHDAA:6389 xref: EMAPA:16328 xref: FMA:3947 xref: GAID:481 xref: MA:0001930 xref: MESH:D002343 xref: NCIT:C32836 xref: SCTID:362045001 xref: TAO:0005081 xref: UMLS:C0007276 {source="ncithesaurus:Internal_Carotid_Artery"} xref: VHOG:0000267 xref: Wikipedia:Internal_carotid_artery xref: XAO:0000366 xref: ZFA:0005081 is_a: UBERON:0003496 ! head blood vessel is_a: UBERON:0005396 {source="MA"} ! carotid artery segment relationship: RO:0002202 UBERON:2001053 {source="cjm"} ! develops from future internal carotid artery relationship: RO:0002380 UBERON:0001530 {source="FMA"} ! branching part of common carotid artery plus branches relationship: RO:0020101 UBERON:0000955 ! vessel supplies blood to brain relationship: RO:0020101 UBERON:0000970 ! vessel supplies blood to eye property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/9/9c/Gray513.png" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "internal carotid artery" xsd:string [Term] id: UBERON:0001533 name: subclavian artery def: "One of two laterally paired arteries that supplies the pectoral appendages, usually branching from the dorsal aorta." [https://orcid.org/0000-0002-6601-2165, ISBN:0073040584] subset: human_reference_atlas subset: pheno_slim subset: uberon_slim subset: unverified_taxonomic_grouping subset: vertebrate_core synonym: "arteria subclavia" EXACT OMO:0003011 [XAO:0000365] synonym: "arteria subclavia" RELATED OMO:0003011 [Wikipedia:Subclavian_artery] synonym: "arterial tree of upper limb" EXACT [] synonym: "PA" RELATED OMO:0003000 [] synonym: "pectoral artery" EXACT [] synonym: "subclavian arterial tree" EXACT [] xref: AAO:0010232 xref: EHDAA2:0001933 xref: EHDAA:4357 xref: EMAPA:17617 xref: FMA:3951 xref: GAID:511 xref: MA:0002045 xref: MESH:D013348 xref: NCIT:C33643 xref: SCTID:265790007 xref: TAO:0005086 xref: UMLS:C0038530 {source="ncithesaurus:Subclavian_Artery"} xref: Wikipedia:Subclavian_artery xref: XAO:0000365 xref: ZFA:0005086 is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0004573 ! systemic artery relationship: RO:0002131 UBERON:0000915 ! overlaps thoracic segment of trunk relationship: RO:0002170 UBERON:0001508 ! connected to arch of aorta relationship: RO:0002202 UBERON:0002457 {source="EHDAA2"} ! develops from intersomitic artery relationship: RO:0002202 UBERON:0005622 {source="EHDAA2"} ! develops from right dorsal aorta relationship: RO:0020101 UBERON:0004710 ! vessel supplies blood to pectoral appendage property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/e/e6/Gray506.svg" xsd:anyURI property_value: IAO:0000116 "Developmental relationships should be added (intersegmental artery and right dorsal aorta in EHDAA2, occipitovertebral artery in XAO)" xsd:string property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "subclavian artery" xsd:string [Term] id: UBERON:0001534 name: right subclavian artery def: "The subclavian artery that supplies the right pectoral appendage." [http://orcid.org/0000-0002-6601-2165] subset: human_reference_atlas subset: pheno_slim subset: uberon_slim synonym: "arteria subclavia dextra" EXACT OMO:0003011 [FMA:3953, FMA:TA] xref: EHDAA2:0004514 xref: EMAPA:37384 {source="MA:th"} xref: FMA:3953 xref: MA:0002047 xref: NCIT:C33490 xref: SCTID:244246000 xref: UMLS:C0226261 {source="ncithesaurus:Right_Subclavian_Artery"} xref: Wikipedia:Subclavian_artery is_a: UBERON:0001533 ! subclavian artery is_a: UBERON:0015212 ! lateral structure intersection_of: UBERON:0001533 ! subclavian artery intersection_of: BSPO:0000121 UBERON:0000468 ! multicellular organism relationship: BSPO:0000121 UBERON:0000468 ! multicellular organism relationship: RO:0002170 UBERON:0001529 ! connected to brachiocephalic artery property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/e/e6/Gray506.svg" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "right subclavian artery" xsd:string [Term] id: UBERON:0001536 name: left common carotid artery plus branches def: "The leftmost of the two common carotid arteries, originating from the aortic arch in the thorax." [UBERON:cjm] subset: human_reference_atlas subset: uberon_slim synonym: "left common carotid artery" EXACT [MA:0001927] synonym: "left common carotid artery" RELATED [FMA:4058] synonym: "trunk of left common carotid tree" EXACT [FMA:4058] xref: EMAPA:35491 xref: FMA:4058 xref: MA:0001927 xref: NCIT:C32956 xref: SCTID:362043008 xref: UMLS:C0226087 {source="ncithesaurus:Left_Common_Carotid_Artery"} xref: Wikipedia:Left_common_carotid_artery is_a: UBERON:0001530 {source="FMA"} ! common carotid artery plus branches property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/e/e6/Gray506.svg" xsd:anyURI property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/blood-vasculature-female/v1.3/assets/3d-vh-f-blood-vasculature.glb" xsd:anyURI property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/blood-vasculature-male/v1.3/assets/3d-vh-m-blood-vasculature.glb" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "left common carotid artery plus branches" xsd:string [Term] id: UBERON:0001544 name: popliteal vein def: "The popliteal vein course runs alongside the popliteal artery but carries the blood from the knee joint and muscles in the thigh and calf back to the heart. Its origin is defined by the junction of the posterior tibial vein and anterior tibial vein. It drains the peroneal vein before reaching the knee joint and turns into the femoral vein when leaving the adductor canal (also known as Hunter's canal). The popliteal artery extends from the femoral artery behind the popliteal fossa which is the space behind the knee. [WP,unvetted]." [Wikipedia:Popliteal_vein] subset: human_reference_atlas subset: uberon_slim synonym: "vena poplitea" RELATED OMO:0003011 [Wikipedia:Popliteal_vein] xref: EMAPA:37181 {source="MA:th"} xref: FMA:44327 xref: GAID:537 xref: galen:PoplitealVein xref: MA:0002197 xref: MESH:D011152 xref: NCIT:C33339 xref: SCTID:281065001 xref: UMLS:C0032652 {source="ncithesaurus:Popliteal_Vein"} xref: Wikipedia:Popliteal_vein is_a: UBERON:0001638 ! vein relationship: RO:0002131 UBERON:0001465 ! overlaps knee relationship: RO:0002376 UBERON:0001361 {source="FMA/obol"} ! tributary of femoral vein property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/6/66/Gray609.png" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001545 name: anterior tibial vein def: "A vein of the lower limb that carries blood from the anterior compartment of the leg to the popliteal vein which is forms when it joins with the posterior tibial vein. Like most deep veins, the anterior tibial vein is accompanied by an artery of the same name, the anterior tibial artery, along its course. [WP,unvetted]." [Wikipedia:Anterior_tibial_vein] subset: human_reference_atlas subset: uberon_slim synonym: "venae tibiales anteriores" RELATED OMO:0003011 [Wikipedia:Anterior_tibial_vein] xref: EMAPA:37135 {source="MA:th"} xref: FMA:44331 xref: galen:AnteriorTibialVein xref: MA:0002244 xref: NCIT:C32115 xref: SCTID:281066000 xref: UMLS:C0226833 {source="ncithesaurus:Anterior_Tibial_Vein"} xref: Wikipedia:Anterior_tibial_vein is_a: UBERON:0010370 {source="MA"} ! tibial vein relationship: RO:0002376 UBERON:0001361 {source="FMA/obol"} ! tributary of femoral vein relationship: RO:0002376 UBERON:0001544 {source="FMA/obol"} ! tributary of popliteal vein property_value: foaf:depiction "https://upload.wikimedia.org/wikipedia/commons/4/4e/Gray440_color.png" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001547 name: small saphenous vein def: "The small saphenous vein (also lesser saphenous vein), is a relatively large vein of the superficial posterior leg. [WP,unvetted]." [Wikipedia:Small_saphenous_vein] subset: human_reference_atlas subset: uberon_slim synonym: "lesser saphenous vein" EXACT [] synonym: "short saphenous vein" EXACT [] synonym: "vena saphena parva" EXACT OMO:0003011 [Wikipedia:Small_saphenous_vein] xref: BTO:0003272 xref: EMAPA:37187 {source="MA:th"} xref: FMA:44333 xref: galen:LesserSaphenousVein xref: MA:0002217 xref: NCIT:C33546 xref: SCTID:181404009 xref: UMLS:C0226827 {source="ncithesaurus:Short_Saphenous_Vein"} xref: Wikipedia:Small_saphenous_vein is_a: UBERON:0007318 ! saphenous vein relationship: RO:0002376 UBERON:0001544 {source="FMA"} ! tributary of popliteal vein property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/6/62/Gray582.png" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001549 name: dorsal metatarsal vein def: "The dorsal metatarsal veins are veins which drain the metatarsus of the foot. [WP,unvetted]." [Wikipedia:Dorsal_metatarsal_veins] subset: human_reference_atlas synonym: "metatarsal vein" EXACT [] synonym: "venae metatarsales dorsales" RELATED OMO:0003011 [Wikipedia:Dorsal_metatarsal_veins] xref: EMAPA:37143 {source="MA:th"} xref: FMA:44377 xref: MA:0002105 xref: NCIT:C52689 xref: UMLS:C0835053 {source="ncithesaurus:Dorsal_Metatarsal_Vein"} xref: Wikipedia:Dorsal_metatarsal_veins is_a: UBERON:0001638 ! vein intersection_of: UBERON:0001638 ! vein intersection_of: RO:0020102 UBERON:0000983 ! vessel drains blood from metatarsus region relationship: RO:0002376 UBERON:0008783 ! tributary of dorsal venous arch relationship: RO:0020102 UBERON:0000983 ! vessel drains blood from metatarsus region property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001550 name: medial marginal vein def: "A continuation of the Dorsal venous arch of the foot and is the origin of the long saphenous vein." [Wikipedia:Medial_marginal_vein] subset: human_reference_atlas synonym: "medial marginal vein of foot" EXACT [] synonym: "vena marginalis medialis" EXACT [] synonym: "vena marginalis medialis pedis" EXACT OMO:0003011 [FMA:44420, FMA:TA] xref: EMAPA:37170 {source="MA:th"} xref: FMA:44420 xref: MA:0002171 xref: Wikipedia:Medial_marginal_vein is_a: UBERON:0001638 ! vein relationship: RO:0002376 UBERON:0001363 {source="FMA/obol"} ! tributary of great saphenous vein property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001552 name: kidney arcuate artery def: "One of the curved arteries at the corticomedullary border of the kidney that arise from the interlobar arteries and give rise to the interlobular arteries." [MP:0011315, Wikipedia:Arcuate_artery_of_the_foot] subset: human_reference_atlas subset: pheno_slim subset: uberon_slim synonym: "arcuate artery" BROAD [MA:0002583] synonym: "renal arcuate artery" EXACT [] xref: EMAPA:28215 xref: FMA:70497 xref: MA:0002583 xref: Wikipedia:Arcuate_arteries_of_the_kidney is_a: UBERON:0001637 ! artery is_a: UBERON:0003644 ! kidney arterial blood vessel relationship: BFO:0000050 UBERON:0001225 {source="MA"} ! part of cortex of kidney relationship: RO:0002252 UBERON:0009885 ! connecting branch of interlobar artery property_value: foaf:depiction "https://upload.wikimedia.org/wikipedia/commons/8/87/2610_The_Kidney.jpg" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001554 name: skin of hip def: "A zone of skin that is part of a hip region." [https://orcid.org/0000-0002-6601-2165, UBERONREF:0000003] synonym: "hip region zone of skin" EXACT [OBOL:automatic] synonym: "hip skin" EXACT [] synonym: "hip zone of skin" EXACT [OBOL:automatic] synonym: "regio coxae zone of skin" EXACT [OBOL:automatic] synonym: "zone of skin of hip" EXACT [OBOL:automatic] synonym: "zone of skin of hip region" EXACT [OBOL:automatic] synonym: "zone of skin of regio coxae" EXACT [OBOL:automatic] xref: EMAPA:18148 xref: FMA:45282 xref: MA:0000658 xref: SCTID:181518004 is_a: UBERON:0000014 ! zone of skin intersection_of: UBERON:0000014 ! zone of skin intersection_of: BFO:0000050 UBERON:0001464 ! part of hip relationship: BFO:0000050 UBERON:0001464 ! part of hip [Term] id: UBERON:0001555 name: digestive tract def: "A tube extending from the mouth to the anus." [https://github.com/geneontology/go-ontology/issues/7549, Wikipedia:Talk\:Human_gastrointestinal_tract] subset: human_reference_atlas subset: uberon_slim subset: vertebrate_core synonym: "alimentary canal" NARROW [] synonym: "alimentary tract" NARROW [] synonym: "digestive canal" RELATED [BTO:0000058] synonym: "digestive tube" EXACT [] synonym: "enteric tract" EXACT [ZFA:0000112] synonym: "gut" BROAD [] synonym: "gut tube" RELATED [] xref: AAO:0010023 xref: BILA:0000083 xref: BTO:0000511 xref: BTO:0000545 xref: EHDAA2:0000726 xref: EHDAA:518 xref: EMAPA:16247 xref: FBbt:00003125 {sssom:mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"} xref: FMA:45615 xref: galen:AlimentaryTract xref: MA:0000917 xref: MESH:D041981 {sssom:mapping_justification="https://w3id.org/semapv/vocab/LexicalMatching"} xref: NCIT:C34082 xref: TAO:0000112 xref: TGMA:0001819 xref: UMLS:C0017189 {source="ncithesaurus:Gastrointestinal_Tract"} xref: VHOG:0000309 xref: WBbt:0005743 xref: ZFA:0000112 is_a: BFO:0000002 is_a: UBERON:0000025 ! tube relationship: BFO:0000050 UBERON:0001007 ! part of digestive system relationship: RO:0002176 UBERON:0000165 ! connects mouth relationship: RO:0002495 UBERON:0007026 {source="NCBIBook:NBK10107"} ! immediate transformation of presumptive gut property_value: RO:0002161 NCBITaxon:147099 {source="Wikipedia:Acoelomorpha"} property_value: RO:0002161 NCBITaxon:41324 {source="DOI:10.1371/journal.pone.0016309"} property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "digestive tract" xsd:string [Term] id: UBERON:0001556 name: lower urinary tract def: "Subdivision of urinary system which consists of the urinary bladder and the urethra." [FMA:45659] subset: human_reference_atlas subset: pheno_slim subset: uberon_slim xref: FMA:45659 xref: galen:LowerUrinaryTract xref: MA:0002636 xref: SCTID:181420004 is_a: BFO:0000002 is_a: UBERON:0011216 ! organ system subdivision relationship: BFO:0000050 UBERON:0001008 ! part of renal system relationship: BFO:0000051 UBERON:0000057 ! has part urethra relationship: BFO:0000051 UBERON:0001255 ! has part urinary bladder property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001557 name: upper respiratory tract def: "The segment of the respiratory tract that starts proximally with the nose and ends distally with the cricoid cartilage, before continuing to the trachea." [http://orcid.org/0000-0002-6601-2165] subset: human_reference_atlas subset: pheno_slim subset: uberon_slim xref: EHDAA2:0002136 xref: EMAPA:17669 xref: FMA:45661 xref: MA:0000442 xref: SCTID:361381009 xref: VHOG:0000406 xref: Wikipedia:Upper_respiratory_tract is_a: BFO:0000002 is_a: UBERON:0000072 ! proximo-distal subdivision of respiratory tract relationship: BFO:0000051 UBERON:0000004 ! has part nose property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/9/9f/Illu_conducting_passages.svg" xsd:anyURI property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/c/c3/Illu_conducting_passages.jpg" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "upper respiratory tract" xsd:string [Term] id: UBERON:0001558 name: lower respiratory tract def: "The segment of the respiratory tract that starts proximally with the trachea and includes all distal structures including the lungs[WP,modified]." [http://orcid.org/0000-0002-6601-2165, Wikipedia:Lower_respiratory_tract] subset: human_reference_atlas subset: pheno_slim subset: uberon_slim synonym: "lower respiratory system" EXACT [] xref: EHDAA2:0001036 xref: EMAPA:16738 xref: FMA:45662 xref: MA:0000435 xref: SCTID:281488008 xref: VHOG:0000382 xref: Wikipedia:Lower_respiratory_tract is_a: BFO:0000002 is_a: UBERON:0000072 ! proximo-distal subdivision of respiratory tract relationship: BFO:0000051 UBERON:0000170 ! has part pair of lungs property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/9/9f/Illu_conducting_passages.svg" xsd:anyURI property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/c/c3/Illu_conducting_passages.jpg" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "lower respiratory tract" xsd:string [Term] id: UBERON:0001560 name: neck of organ subset: non_informative synonym: "organ neck" EXACT [] xref: FMA:45733 is_a: UBERON:0034944 {source="FMA"} ! zone of organ relationship: RO:0002162 NCBITaxon:6072 ! in taxon Eumetazoa [Term] id: UBERON:0001567 name: cheek def: "A fleshy subdivision of one side of the face bounded by an eye, ear and the nose." [http://orcid.org/0000-0002-6601-2165, Wikipedia:Cheek] subset: pheno_slim subset: uberon_slim synonym: "buccae" RELATED OMO:0003011 [Wikipedia:Cheek] synonym: "jowl" RELATED [Wikipedia:Cheek] xref: BTO:0001754 xref: EMAPA:37451 {source="MA:th"} xref: FMA:46476 xref: GAID:65 xref: galen:Cheek xref: MA:0002475 xref: MESH:D002610 xref: NCIT:C13070 xref: SCTID:182325008 xref: TAO:0002113 xref: UMLS:C0007966 {source="ncithesaurus:Cheek"} xref: Wikipedia:Cheek is_a: UBERON:0015212 ! lateral structure is_a: UBERON:0034929 ! external soft tissue zone relationship: BFO:0000050 UBERON:0004089 ! part of midface relationship: BFO:0000050 UBERON:8480069 ! part of temporofacial region relationship: BSPO:0000126 UBERON:0001456 {source="FMA-abduced-lr"} ! face property_value: foaf:depiction "https://upload.wikimedia.org/wikipedia/commons/a/a9/Chica_cachetona.jpg" xsd:anyURI [Term] id: UBERON:0001568 name: muscle of larynx def: "The muscles associated with the larynx." [MP:0002263] subset: human_reference_atlas subset: pheno_slim synonym: "laryngeal muscle" EXACT [] synonym: "larynx muscle" EXACT [] synonym: "larynx muscle organ" EXACT [OBOL:automatic] synonym: "muscle organ of larynx" EXACT [OBOL:automatic] synonym: "musculi laryngeales" EXACT [] xref: BTO:0001626 xref: EMAPA:35473 xref: FMA:46562 xref: GAID:144 xref: MA:0001768 xref: MESH:D007821 xref: NCIT:C32934 xref: SCTID:181744001 xref: UMLS:C0023054 {source="ncithesaurus:Laryngeal_Muscle"} xref: Wikipedia:Muscles_of_larynx is_a: UBERON:0002377 ! muscle of neck is_a: UBERON:0003831 ! respiratory system muscle intersection_of: UBERON:0014892 ! skeletal muscle organ, vertebrate intersection_of: BFO:0000050 UBERON:0001737 ! part of larynx relationship: BFO:0000050 UBERON:0004478 {source="prolog"} ! part of musculature of larynx relationship: RO:0002433 UBERON:0001015 ! contributes to morphology of musculature relationship: RO:0002433 UBERON:0001737 ! contributes to morphology of larynx property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "muscle of larynx" xsd:string [Term] id: UBERON:0001571 name: genioglossus muscle def: "Either of a pair of lingual muscles with origin in the mandible, with insertion to the lingual fascia below the mucous membrane and epiglottis, with nerve supply from the hypoglossal nerve, and whose action depresses and protrudes the tongue." [VHOG:0000847, Wikipedia:Genioglossus_muscle] subset: human_reference_atlas subset: uberon_slim synonym: "genioglossus" EXACT [] synonym: "m. genioglossus" EXACT [] synonym: "musculus genioglossus" EXACT [] xref: AAO:0010660 xref: EHDAA2:0000704 xref: EHDAA:9150 xref: EMAPA:18276 xref: FMA:46690 xref: MA:0002307 xref: NCIT:C52928 xref: SCTID:244784007 xref: UMLS:C0224194 {source="ncithesaurus:Genioglossus"} xref: VHOG:0000847 xref: Wikipedia:Genioglossus_muscle is_a: UBERON:0001575 {source="FMA"} ! extrinsic muscle of tongue is_a: UBERON:0004120 ! mesoderm-derived structure relationship: RO:0002202 UBERON:0010059 {source="EHDAA2"} ! develops from hypoglossal cord relationship: RO:0002372 UBERON:0006606 ! has muscle origin mandibular symphysis relationship: RO:0002373 UBERON:0009471 {source="Wikipedia"} ! has muscle insertion dorsum of tongue property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/7/7e/Genioglossus.png" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "genioglossus muscle" xsd:string [Term] id: UBERON:0001572 name: hyoglossus muscle def: "A muscle that attaches to the hyopid bone and to the tongue and is innervated by cranial nerve XII." [FEED:rd] subset: human_reference_atlas subset: uberon_slim synonym: "hyoglossus" EXACT [Wikipedia:Hyoglossus] synonym: "m. hyoglossus" EXACT [] xref: AAO:0010663 xref: EMAPA:18277 xref: FMA:46691 xref: MA:0002317 xref: MFMO:0000064 xref: NCIT:C53161 xref: SCTID:244785008 xref: UMLS:C0224196 {source="ncithesaurus:Hyoglossus_Muscle"} xref: Wikipedia:Hyoglossus_muscle is_a: UBERON:0001575 {source="FMA"} ! extrinsic muscle of tongue intersection_of: UBERON:0014892 ! skeletal muscle organ, vertebrate intersection_of: RO:0002005 UBERON:0001650 ! innervated by hypoglossal nerve intersection_of: RO:0002371 UBERON:0001685 ! attached to hyoid bone intersection_of: RO:0002371 UBERON:0001723 ! attached to tongue relationship: RO:0002372 UBERON:0001685 ! has muscle origin hyoid bone relationship: RO:0002373 UBERON:0001723 ! has muscle insertion tongue property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/7/7e/Hyoglossus.png" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "hyoglossus muscle" xsd:string [Term] id: UBERON:0001575 name: extrinsic muscle of tongue def: "A muscle organ that attaches the tongue to some other structure." [https://github.com/obophenotype/uberon/issues/331, Wikipedia:Muscles_of_tongue] subset: human_reference_atlas synonym: "extrinsic lingual muscle" EXACT [] synonym: "extrinsic tongue muscle" EXACT [] xref: EHDAA2:0002063 xref: EHDAA:9148 xref: EMAPA:18275 xref: FMA:46699 xref: MA:0002296 xref: SCTID:244782006 xref: VHOG:0000825 is_a: UBERON:0000378 {is_inferred="true"} ! tongue muscle intersection_of: UBERON:0014892 ! skeletal muscle organ, vertebrate intersection_of: RO:0002005 UBERON:0001650 ! innervated by hypoglossal nerve intersection_of: RO:0002177 UBERON:0001723 ! attached to part of tongue intersection_of: RO:0002371 UBERON:0004765 ! attached to skeletal element relationship: RO:0002005 UBERON:0001650 ! innervated by hypoglossal nerve relationship: RO:0002371 UBERON:0004765 ! attached to skeletal element relationship: RO:0002495 UBERON:0011332 ! immediate transformation of extrinsic tongue pre-muscle mass property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "extrinsic muscle of tongue" xsd:string property_value: terms:contributor https://orcid.org/0000-0001-9114-8737 property_value: terms:contributor https://orcid.org/0000-0002-1572-1316 property_value: terms:contributor https://orcid.org/0000-0002-6601-2165 property_value: terms:contributor https://orcid.org/0000-0002-7073-9172 [Term] id: UBERON:0001576 name: intrinsic muscle of tongue def: "The intrinsic tongue muscles are an integral part of the tongue and completely contained within the tongue that are innervated by Cranial Nerve XII." [http://www.feedexp.org/wiki/Mammalian_Muscle_Ontology_Workshop] subset: human_reference_atlas synonym: "intrinsic lingual muscle" EXACT [] synonym: "intrinsic tongue muscle" EXACT [] xref: EHDAA2:0002064 xref: EHDAA:9152 xref: EMAPA:18280 xref: FMA:46701 xref: MA:0002327 xref: SCTID:244788005 xref: VHOG:0000748 is_a: UBERON:0000378 {is_inferred="true"} ! tongue muscle is_a: UBERON:0004120 ! mesoderm-derived structure intersection_of: UBERON:0014892 ! skeletal muscle organ, vertebrate intersection_of: BFO:0000050 UBERON:0001723 ! part of tongue intersection_of: RO:0002005 UBERON:0001650 ! innervated by hypoglossal nerve intersection_of: RO:0002177 UBERON:0001723 ! attached to part of tongue relationship: BFO:0000050 UBERON:0001723 ! part of tongue relationship: RO:0002005 UBERON:0001650 {source="FEED", source="Wikipedia"} ! innervated by hypoglossal nerve relationship: RO:0002202 UBERON:0010059 {source="EHDAA2"} ! develops from hypoglossal cord property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "intrinsic muscle of tongue" xsd:string [Term] id: UBERON:0001577 name: facial muscle def: "A muscle innervated by a facial nerve." [FEED:rd] subset: pheno_slim subset: uberon_slim synonym: "cranial-facial muscle" RELATED [EMAPA:25133] synonym: "cranio-facial muscle" RELATED [EMAPA:25133] synonym: "craniofacial muscle" RELATED [EMAPA:25133] synonym: "face muscle" EXACT [FMA:46751] synonym: "face muscle organ" EXACT [OBOL:automatic] synonym: "facial muscle" EXACT [FMA:46751, XAO:0001013] synonym: "facial muscle proper" EXACT [] synonym: "facial nerve innervated muscle" EXACT [https://orcid.org/0000-0002-6601-2165] synonym: "facial nerve muscle" EXACT [] synonym: "mimetic muscles" RELATED [Wikipedia:Facial_muscles] synonym: "muscle of face" EXACT [FMA:46751] synonym: "muscle of facil expression" RELATED [Wikipedia:Facial_muscles] synonym: "muscle organ of face" EXACT [OBOL:automatic] synonym: "muscles of facial expression" RELATED [Wikipedia:Facial_muscles] synonym: "musculi faciei" RELATED OMO:0003011 [Wikipedia:Facial_muscles] xref: FMA:46751 xref: GAID:143 xref: MA:0003160 xref: MESH:D005152 xref: MFMO:0000005 xref: NCIT:C13073 xref: SCTID:25903009 xref: UMLS:C0015460 {source="ncithesaurus:Facial_Muscle"} xref: Wikipedia:Facial_muscles xref: XAO:0001013 is_a: UBERON:0015789 ! cranial or facial muscle intersection_of: UBERON:0014892 ! skeletal muscle organ, vertebrate intersection_of: RO:0002005 UBERON:0001647 ! innervated by facial nerve relationship: RO:0002005 UBERON:0001647 ! innervated by facial nerve relationship: RO:0002202 UBERON:0003066 {source="FEED", source="Wikipedia"} ! develops from pharyngeal arch 2 property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/f/fa/Gray378.png" xsd:anyURI property_value: skos:prefLabel "facial muscle" xsd:string [Term] id: UBERON:0001579 name: olfactory nerve def: "Nerve that carries information from the olfactory epithelium to the olfactory bulb[Butler and Hodos]." [ISBN:0471209627, Wikipedia:Olfactory_nerve] subset: human_reference_atlas subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "1n" BROAD OMO:0003000 [BIRNLEX:1319, NIFSTD:NeuroNames_abbrevSource] synonym: "CN-I" RELATED [] synonym: "cranial nerve I" RELATED [] synonym: "fila olfactoria" RELATED [BTO:0003648] synonym: "first cranial nerve" EXACT [] synonym: "nerve I" RELATED [NeuroNames:32] synonym: "nerve of smell" RELATED [BTO:0003648] synonym: "nervus olfactorius" RELATED OMO:0003011 [BTO:0003648, Wikipedia:Olfactory_nerve] synonym: "nervus olfactorius [i]" EXACT OMO:0003011 [FMA:46787, FMA:TA] synonym: "olfactoria fila" RELATED [NeuroNames:32] synonym: "olfactory fila" RELATED [BTO:0003648] synonym: "olfactory I" EXACT [EHDAA2:0001293] synonym: "olfactory i nerve" EXACT [] synonym: "olfactory nerve [I]" EXACT [] xref: AAO:0010088 xref: BAMS:1n xref: BAMS:ln xref: BIRNLEX:1319 xref: BTO:0003648 xref: EHDAA2:0001293 xref: EHDAA:6672 xref: EMAPA:17797 xref: FMA:46787 xref: GAID:830 xref: HBA:9300 xref: MA:0001096 xref: MBA:840 xref: MESH:D009832 xref: NCIT:C12759 xref: neuronames:32 {source="BIRNLEX:1319"} xref: SCTID:180937006 xref: TAO:0000249 xref: UMLS:C0028938 {source="ncithesaurus:Olfactory_Nerve", source="BIRNLEX:1319"} xref: UMLS:C1268984 {source="BIRNLEX:1319"} xref: VHOG:0000703 xref: Wikipedia:Olfactory_nerve xref: XAO:0000426 xref: ZFA:0000249 is_a: UBERON:0001785 ! cranial nerve is_a: UBERON:0004121 ! ectoderm-derived structure intersection_of: UBERON:0001785 ! cranial nerve intersection_of: extends_fibers_into UBERON:0002264 ! olfactory bulb intersection_of: RO:0002134 UBERON:0001997 ! innervates olfactory epithelium relationship: extends_fibers_into UBERON:0002264 ! olfactory bulb relationship: RO:0002134 UBERON:0001997 {source="ISBN:0471888893"} ! innervates olfactory epithelium relationship: RO:0002202 UBERON:0003050 {source="ISBN:0471888893"} ! develops from olfactory placode property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/b/be/Gray771.png" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "olfactory nerve" xsd:string [Term] id: UBERON:0001584 name: left subclavian artery def: "The subclavian artery that supplies the left pectoral appendage." [http://orcid.org/0000-0002-6601-2165] subset: human_reference_atlas subset: pheno_slim subset: uberon_slim synonym: "arteria subclavia (sinistra)" EXACT OMO:0003011 [FMA:4694, FMA:TA] xref: EMAPA:37100 {source="MA:th"} xref: FMA:4694 xref: MA:0002046 xref: NCIT:C32972 xref: SCTID:244245001 xref: UMLS:C0226262 {source="ncithesaurus:Left_Subclavian_Artery"} xref: Wikipedia:Subclavian_artery is_a: UBERON:0001533 ! subclavian artery is_a: UBERON:0015212 ! lateral structure intersection_of: UBERON:0001533 ! subclavian artery intersection_of: BSPO:0000120 UBERON:0000468 ! multicellular organism relationship: BSPO:0000120 UBERON:0000468 ! multicellular organism relationship: channels_from UBERON:0001508 ! arch of aorta property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/e/e6/Gray506.svg" xsd:anyURI property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/blood-vasculature-female/v1.3/assets/3d-vh-f-blood-vasculature.glb" xsd:anyURI property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/blood-vasculature-male/v1.3/assets/3d-vh-m-blood-vasculature.glb" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "left subclavian artery" xsd:string [Term] id: UBERON:0001585 name: anterior vena cava def: "A vein that carries deoxygenated blood from the upper half of the body into the right atrium of the heart." [http://orcid.org/0000-0002-6601-2165, Wikipedia:Superior_vena_cava] subset: human_reference_atlas subset: pheno_slim subset: uberon_slim synonym: "cranial vena cava" RELATED [VHOG:0001195] synonym: "precava" RELATED [] synonym: "superior caval vein" EXACT [http://orcid.org/0000-0002-6601-2165] synonym: "superior vena cava" EXACT [FMA:4720] synonym: "vena cava superior" RELATED OMO:0003011 [BTO:0002683, Wikipedia:Superior_vena_cava] synonym: "vena maxima" RELATED OMO:0003011 [Wikipedia:Superior_vena_cava] xref: BTO:0002683 xref: EHDAA2:0001962 xref: EHDAA:8726 xref: EMAPA:18417 xref: FMA:4720 xref: GAID:549 xref: galen:SuperiorVenaCava xref: MA:0000481 xref: MESH:D014683 xref: NCIT:C12816 xref: SCTID:181368006 xref: UMLS:C0042459 {source="ncithesaurus:Superior_Vena_Cava"} xref: VHOG:0001195 xref: Wikipedia:Superior_vena_cava is_a: UBERON:0004087 ! vena cava intersection_of: UBERON:0004087 ! vena cava intersection_of: RO:0020102 UBERON:0000153 ! vessel drains blood from anterior region of body relationship: RO:0002170 UBERON:0002078 ! connected to right cardiac atrium relationship: RO:0020102 UBERON:0000153 ! vessel drains blood from anterior region of body property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/b/b4/Venenwinkel.png" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "anterior vena cava" xsd:string [Term] id: UBERON:0001586 name: internal jugular vein def: "One of two jugular veins that collect the blood from the brain, the superficial parts of the face, and the neck. [WP,unvetted]." [Wikipedia:Internal_jugular_vein] subset: human_reference_atlas subset: uberon_slim synonym: "internal jugular" EXACT [EHDAA2:0000877] synonym: "internal jugular venous tree" EXACT [] synonym: "vena jugularis interna" RELATED OMO:0003011 [Wikipedia:Internal_jugular_vein] xref: AAO:0010236 xref: EHDAA2:0000877 xref: EHDAA:5407 xref: EMAPA:17620 xref: FMA:4724 xref: galen:InternalJugularVein xref: MA:0002157 xref: NCIT:C32849 xref: RETIRED_EHDAA2:0000878 xref: SCTID:181372005 xref: UMLS:C0226550 {source="ncithesaurus:Internal_Jugular_Vein"} xref: Wikipedia:Internal_jugular_vein xref: XAO:0000382 is_a: UBERON:0004711 ! jugular vein relationship: RO:0002170 UBERON:0003711 ! connected to brachiocephalic vein relationship: RO:0020102 UBERON:0000955 ! vessel drains blood from brain relationship: RO:0020102 UBERON:0001456 ! vessel drains blood from face property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/e/e9/Gray562.png" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "internal jugular vein" xsd:string [Term] id: UBERON:0001587 name: subclavian vein def: "The subclavian vein is a paired large vein, one on either side of the body. Their diameter is approximately that of the smallest finger." [Wikipedia:Subclavian_vein] subset: human_reference_atlas subset: uberon_slim synonym: "subclavian venous tree" EXACT [] synonym: "vena subclavia" EXACT OMO:0003011 [Wikipedia:Subclavian_vein] xref: AAO:0010510 xref: EHDAA2:0001934 xref: EHDAA:4455 xref: EMAPA:17621 xref: FMA:4725 xref: GAID:546 xref: galen:SubclavianVein xref: MA:0002221 xref: MESH:D013350 xref: NCIT:C12794 xref: SCTID:181388005 xref: UMLS:C0038532 {source="ncithesaurus:Subclavian_Vein"} xref: Wikipedia:Subclavian_vein is_a: UBERON:0001638 ! vein relationship: RO:0002170 UBERON:0003711 ! connected to brachiocephalic vein relationship: RO:0020102 UBERON:0004710 ! vessel drains blood from pectoral appendage property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/9/9e/Gray1174.png" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001591 name: thymic vein def: "A vein that drains blood from the thymus." [http://orcid.org/0000-0002-6601-2165] subset: human_reference_atlas synonym: "thymic tributary of brachiocephalic vein" EXACT [] synonym: "vena thymica" EXACT OMO:0003011 [Wikipedia:Thymic_veins] synonym: "venae thymicae" RELATED OMO:0003011 [Wikipedia:Thymic_veins] xref: EMAPA:36325 xref: FMA:4747 xref: MA:0002246 xref: NCIT:C53143 xref: SCTID:303432009 xref: UMLS:C0226698 {source="ncithesaurus:Thymic_Vein"} xref: Wikipedia:Thymic_veins is_a: UBERON:0001638 ! vein intersection_of: UBERON:0001638 ! vein intersection_of: RO:0020102 UBERON:0002370 ! vessel drains blood from thymus relationship: RO:0002376 UBERON:0003711 ! tributary of brachiocephalic vein relationship: RO:0020102 UBERON:0002370 ! vessel drains blood from thymus property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001592 name: bronchial vein def: "The bronchial veins are small vessels that return blood from the larger bronchi and structures at the roots of the lungs. The right side drains into the azygos vein, while the left side drains into the left superior intercostal vein or the accessory hemiazygos vein. The bronchial veins are counterparts to the bronchial arteries. The veins, however, do not return all of the blood supplied by the arteries; much of the blood that is carried in the bronchial arteries is returned to the heart via the pulmonary veins. [WP,unvetted]." [Wikipedia:Bronchial_veins] subset: human_reference_atlas subset: uberon_slim synonym: "bronchial venous tree" EXACT [] xref: EMAPA:36284 xref: FMA:4749 xref: MA:0002088 xref: NCIT:C53031 xref: SCTID:198293000 xref: UMLS:C0226650 {source="ncithesaurus:Bronchial_Vein"} xref: Wikipedia:Bronchial_veins is_a: UBERON:0001638 ! vein intersection_of: UBERON:0001638 ! vein intersection_of: RO:0020102 UBERON:0002185 ! vessel drains blood from bronchus relationship: RO:0020102 UBERON:0002185 ! vessel drains blood from bronchus property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "bronchial vein" xsd:string [Term] id: UBERON:0001593 name: venous plexus def: "A congregation of multiple veins." [Wikipedia:Venous_plexus] subset: uberon_slim synonym: "plexus venosus" RELATED OMO:0003011 [Wikipedia:Venous_plexus] synonym: "rete venosum" RELATED OMO:0003011 [Wikipedia:Venous_plexus] synonym: "venous network" EXACT [] xref: EMAPA:36327 xref: FMA:4767 xref: MA:0000069 xref: SCTID:322151008 xref: Wikipedia:Venous_plexus is_a: UBERON:0004537 ! blood vasculature is_a: UBERON:0005629 ! vascular plexus intersection_of: UBERON:0005629 ! vascular plexus intersection_of: RO:0002473 UBERON:0001638 ! composed primarily of vein relationship: RO:0002473 UBERON:0001638 ! composed primarily of vein property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/b/bd/Gray585.png" xsd:anyURI property_value: skos:prefLabel "venous plexus" xsd:string [Term] id: UBERON:0001601 name: extra-ocular muscle def: "Skeletal muscle derived from cranial mesoderm and controls eye movements." [GO:0002074, Wikipedia:Extraocular_muscles] subset: efo_slim subset: human_reference_atlas subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "extra-ocular skeletal muscle" EXACT [] synonym: "extraocular muscle" EXACT [FMA:49033] synonym: "extraocular musculature" EXACT [ZFA:0000511] synonym: "extraocular skeletal muscle" EXACT [MA:0001271] synonym: "extrinsic eye muscle" EXACT [OBOL:automatic] synonym: "extrinsic muscle of eyeball" EXACT [FMA:49033] synonym: "extrinsic ocular muscle" EXACT [EHDAA2:0000482] synonym: "musculi externi bulbi oculi" RELATED OMO:0003011 [Wikipedia:Extraocular_muscles] xref: AAO:0010028 xref: BTO:0001579 xref: CALOHA:TS-0305 xref: EFO:0001921 xref: EHDAA2:0000482 xref: EHDAA:5729 xref: EMAPA:18234 xref: FMA:49033 xref: MA:0001271 xref: MESH:D009801 {sssom:mapping_justification="https://w3id.org/semapv/vocab/LexicalMatching"} xref: SCTID:181150000 xref: TAO:0000511 xref: VHOG:0000549 xref: Wikipedia:Extraocular_muscles xref: ZFA:0000511 is_a: UBERON:0004277 ! eye muscle is_a: UBERON:0010959 ! craniocervical muscle relationship: BFO:0000050 UBERON:0003269 {source="EHDAA2"} ! part of skeletal muscle tissue of eye relationship: BFO:0000050 UBERON:0035639 {source="HPO:pr"} ! part of ocular adnexa relationship: RO:0002202 UBERON:0006230 {source="EHDAA2"} ! develops from extrinsic ocular pre-muscle mass property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/6/61/MRI_of_human_eye.jpg" xsd:anyURI property_value: IAO:0000116 "todo - resolve discrepancies in which muscles are considered extra-ocular" xsd:string property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "extra-ocular muscle" xsd:string [Term] id: UBERON:0001605 name: ciliary muscle def: "The ciliary muscle is a ring of smooth muscle in the middle layer of the eye that controls the eye's accommodation for viewing objects at varying distances and regulates the flow of aqueous humour through Schlemm's canal. [WP,unvetted]." [Wikipedia:Ciliary_muscle] subset: human_reference_atlas subset: pheno_slim subset: uberon_slim synonym: "Bowman`s muscles" RELATED [BTO:0000654] synonym: "ciliaris" RELATED [Wikipedia:Ciliary_muscle] synonym: "musculus ciliaris" RELATED OMO:0003011 [Wikipedia:Ciliary_muscle] synonym: "musculus ciliarus" EXACT [BTO:0000654] xref: BTO:0000654 xref: EMAPA:35240 xref: FMA:49151 xref: MA:0001269 xref: NCIT:C32315 xref: SCTID:280862009 xref: UMLS:C0559230 {source="ncithesaurus:Ciliary_Muscle"} xref: Wikipedia:Ciliary_muscle is_a: UBERON:0003386 {source="MA"} ! smooth muscle of eye is_a: UBERON:0010314 ! structure with developmental contribution from neural crest is_a: UBERON:0011222 {source="FMA"} ! intra-ocular muscle relationship: BFO:0000050 UBERON:0001775 {source="FMA"} ! part of ciliary body property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/2/28/Gray872.png" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "ciliary muscle" xsd:string [Term] id: UBERON:0001606 name: muscle of iris subset: uberon_slim synonym: "iris muscle" EXACT [] synonym: "iris muscle organ" EXACT [OBOL:automatic] synonym: "muscle organ of iris" EXACT [OBOL:automatic] xref: FMA:49154 xref: MA:0001287 xref: SCTID:280888007 xref: Wikipedia:Iris_muscle is_a: UBERON:0011222 {source="FMA"} ! intra-ocular muscle intersection_of: UBERON:0001630 ! muscle organ intersection_of: BFO:0000050 UBERON:0001769 ! part of iris relationship: BFO:0000050 UBERON:0001769 ! part of iris property_value: IAO:0000116 "revisit this, see issue #331" xsd:string property_value: skos:prefLabel "muscle of iris" xsd:string [Term] id: UBERON:0001607 name: sphincter pupillae def: "A sphincter muscle that is part of the iris." [Wikipedia:Iris_sphincter_muscle] subset: uberon_slim synonym: "circular fibers" RELATED [Wikipedia:Iris_sphincter_muscle] synonym: "constrictor pupillae" RELATED [Wikipedia:Iris_sphincter_muscle] synonym: "iris constrictor" RELATED [] synonym: "iris constrictor muscle" RELATED [Wikipedia:Iris_sphincter_muscle] synonym: "iris sphincter" RELATED [Wikipedia:Iris_sphincter_muscle] synonym: "iris sphincter muscle" EXACT [BTO:0000656] synonym: "M. sphincter pupillae" EXACT [] synonym: "m. sphincter pupillae" RELATED OMO:0003011 [Wikipedia:Iris_sphincter_muscle] synonym: "musculus sphincter pupillae" EXACT [BTO:0000656] synonym: "pupillary constrictor muscle" RELATED [Wikipedia:Iris_sphincter_muscle] synonym: "pupillary sphincter" RELATED [Wikipedia:Iris_sphincter_muscle] synonym: "pupillary sphincter muscle" RELATED [Wikipedia:Iris_sphincter_muscle] synonym: "sphincter muscle of pupil" EXACT [BTO:0000656] synonym: "sphincter pupillae" RELATED [Wikipedia:Iris_sphincter_muscle] synonym: "sphincter pupillae muscle" RELATED [Wikipedia:Iris_sphincter_muscle] synonym: "spincter pupillae" RELATED [Wikipedia:Iris_sphincter_muscle] xref: BTO:0000656 xref: EMAPA:35788 xref: FMA:49157 xref: MA:0001289 xref: NCIT:C33586 xref: SCTID:280889004 xref: UMLS:C0229189 {source="ncithesaurus:Sphincter_Pupillae_Muscle"} xref: Wikipedia:Iris_sphincter_muscle is_a: UBERON:0001606 ! muscle of iris is_a: UBERON:0004121 ! ectoderm-derived structure is_a: UBERON:0004234 {source="BTO"} ! iris smooth muscle is_a: UBERON:0007521 ! smooth muscle sphincter intersection_of: UBERON:0004590 ! sphincter muscle intersection_of: BFO:0000050 UBERON:0001769 ! part of iris relationship: RO:0002202 UBERON:0002346 {source="ISBN:0781772214"} ! develops from neurectoderm relationship: RO:0002372 UBERON:0001769 ! has muscle origin iris relationship: RO:0002373 UBERON:0001769 ! has muscle insertion iris relationship: RO:0002568 UBERON:0001608 {source="dbpedia"} ! has muscle antagonist dilatator pupillae property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/2/2f/Gray878.png" xsd:anyURI property_value: skos:prefLabel "sphincter pupillae" xsd:string [Term] id: UBERON:0001608 name: dilatator pupillae def: "A smooth muscle of the eye, running radially in the iris that functions as a dilator. [WP,unvetted]." [Wikipedia:Iris_dilator_muscle] subset: human_reference_atlas subset: uberon_slim synonym: "dilator muscle of pupil" EXACT [] synonym: "dilator of pupil" EXACT [] synonym: "dilator pupillae" EXACT [] synonym: "dilator pupillae muscle" EXACT [Wikipedia:Iris_dilator_muscle] synonym: "dilator pupillae muscle" RELATED [BTO:0001371] synonym: "iris dilator" RELATED [Wikipedia:Iris_dilator_muscle] synonym: "iris dilator muscle" EXACT [BTO:0001371] synonym: "musculus dilatator pupillae" EXACT OMO:0003011 [FMA:49158, FMA:TA] synonym: "musculus dilatator pupillae" RELATED OMO:0003011 [Wikipedia:Iris_dilator_muscle] synonym: "musculus dilator pupillae" RELATED [BTO:0001371] synonym: "pupil dilator" RELATED [Wikipedia:Iris_dilator_muscle] synonym: "pupil dilator muscle" RELATED [Wikipedia:Iris_dilator_muscle] synonym: "pupillary dilator" RELATED [Wikipedia:Iris_dilator_muscle] synonym: "pupillary dilator muscle" EXACT [Wikipedia:Iris_dilator_muscle] synonym: "pupillary muscle" RELATED [Wikipedia:Iris_dilator_muscle] synonym: "radial muscle" RELATED [Wikipedia:Iris_dilator_muscle] synonym: "radial muscle of iris" EXACT [Wikipedia:Iris_dilator_muscle] synonym: "radiating fibers" RELATED [Wikipedia:Iris_dilator_muscle] xref: BTO:0001371 xref: EMAPA:35286 xref: FMA:49158 xref: MA:0001288 xref: NCIT:C32463 xref: SCTID:280890008 xref: UMLS:C0229190 {source="ncithesaurus:Dilator_Pupillae_Muscle"} xref: Wikipedia:Iris_dilator_muscle is_a: UBERON:0004121 ! ectoderm-derived structure is_a: UBERON:0004234 {source="BTO"} ! iris smooth muscle relationship: RO:0002202 UBERON:0002346 {source="ISBN:0781772214"} ! develops from neurectoderm relationship: RO:0002372 UBERON:0001769 ! has muscle origin iris relationship: RO:0002373 UBERON:0001769 ! has muscle insertion iris relationship: RO:0002568 UBERON:0001607 {source="dbpedia"} ! has muscle antagonist sphincter pupillae property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/2/2f/Gray878.png" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "dilatator pupillae" xsd:string [Term] id: UBERON:0001610 name: lingual artery def: "The lingual artery arises from the external carotid between the superior thyroid and facial artery[WP]." [Wikipedia:Lingual_artery] subset: human_reference_atlas subset: uberon_slim synonym: "arteria lingualis" RELATED OMO:0003011 [Wikipedia:Lingual_artery] synonym: "lingual branch of external carotid artery" EXACT [] xref: AAO:0010492 xref: EMAPA:36324 xref: FMA:49526 xref: MA:0001992 xref: NCIT:C52961 xref: SCTID:181327002 xref: UMLS:C0226104 {source="ncithesaurus:Lingual_Artery"} xref: Wikipedia:Lingual_artery is_a: UBERON:0015212 ! lateral structure is_a: UBERON:0035398 ! branch of external carotid artery intersection_of: UBERON:0001637 ! artery intersection_of: RO:0020101 UBERON:0001723 ! vessel supplies blood to tongue relationship: BSPO:0000126 UBERON:0001723 {source="FMA-abduced-lr"} ! tongue relationship: RO:0020101 UBERON:0001723 ! vessel supplies blood to tongue property_value: foaf:depiction "https://upload.wikimedia.org/wikipedia/commons/3/3c/Lingual_artery.PNG" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "lingual artery" xsd:string [Term] id: UBERON:0001611 name: sublingual artery def: "A branch of the lingual artery that supplies the sublingual gland." [http://orcid.org/0000-0002-6601-2165] subset: human_reference_atlas subset: uberon_slim synonym: "arteria sublingualis" RELATED OMO:0003011 [Wikipedia:Sublingual_artery] synonym: "sublingual branch of lingual artery" EXACT [] xref: AAO:0010491 xref: EMAPA:37115 {source="MA:th"} xref: FMA:49543 xref: MA:0002049 xref: NCIT:C53002 xref: SCTID:368706006 xref: UMLS:C0226106 {source="ncithesaurus:Sublingual_Artery"} xref: Wikipedia:Sublingual_artery is_a: UBERON:0001637 ! artery intersection_of: UBERON:0001637 ! artery intersection_of: RO:0020101 UBERON:0001832 ! vessel supplies blood to sublingual gland relationship: RO:0002252 UBERON:0001610 {source="FMA"} ! connecting branch of lingual artery relationship: RO:0020101 UBERON:0001832 ! vessel supplies blood to sublingual gland property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/7/7a/Gray559.png" xsd:anyURI property_value: IAO:0000116 "Check grouping with amphibian structure of the same name" xsd:string property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001612 name: facial artery def: "A branch of the external carotid artery that supplies structures of the face. [WP,unvetted]." [Wikipedia:Facial_artery] subset: human_reference_atlas subset: uberon_slim synonym: "arteria maxillaris externa" RELATED OMO:0003011 [Wikipedia:Facial_artery] synonym: "external maxillary artery" RELATED [] xref: EMAPA:19213 xref: FMA:49549 xref: MA:0001950 xref: NCIT:C32578 xref: SCTID:181328007 xref: UMLS:C0226109 {source="ncithesaurus:Facial_Artery"} xref: Wikipedia:Facial_artery is_a: UBERON:0035398 ! branch of external carotid artery intersection_of: UBERON:0001637 ! artery intersection_of: RO:0002252 UBERON:0001070 ! connecting branch of external carotid artery intersection_of: RO:0020101 UBERON:0001456 ! vessel supplies blood to face relationship: RO:0020101 UBERON:0001456 ! vessel supplies blood to face property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/7/7b/Gray508.png" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "facial artery" xsd:string [Term] id: UBERON:0001613 name: occipital artery def: "The occipital artery arises opposite the facial artery, its path is below the posterior belly of digastric to the occipital region. This artery supplies blood to the back of the scalp and sterno-mastoid muscles. Other muscles it supplies are deep muscles in the back and neck. [WP,unvetted]." [Wikipedia:Occipital_artery] subset: human_reference_atlas subset: uberon_slim synonym: "arteria occipitalis" RELATED OMO:0003011 [Wikipedia:Occipital_artery] xref: EMAPA:37672 {source="MA:th"} xref: FMA:49586 xref: MA:0002009 xref: NCIT:C33194 xref: SCTID:244219005 xref: UMLS:C0226117 {source="ncithesaurus:Occipital_Artery"} xref: Wikipedia:Occipital_artery is_a: UBERON:0035398 ! branch of external carotid artery intersection_of: UBERON:0001637 ! artery intersection_of: RO:0002252 UBERON:0001070 ! connecting branch of external carotid artery intersection_of: RO:0020101 UBERON:0000403 ! vessel supplies blood to scalp intersection_of: RO:0020101 UBERON:0002377 ! vessel supplies blood to muscle of neck relationship: RO:0020101 UBERON:0000403 ! vessel supplies blood to scalp relationship: RO:0020101 UBERON:0002377 ! vessel supplies blood to muscle of neck property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/7/7b/Gray508.png" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001616 name: maxillary artery def: "An artery that supplies deep structures of the face. It comes just out behind the neck of the mandible. [WP,unvetted]." [Wikipedia:Maxillary_artery] subset: human_reference_atlas subset: uberon_slim synonym: "arteria maxillaris" RELATED OMO:0003011 [Wikipedia:Maxillary_artery] synonym: "internal maxillary artery" RELATED [] xref: EHDAA2:0001069 xref: EHDAA:7357 xref: EMAPA:17311 xref: FMA:49675 xref: GAID:498 xref: MA:0001919 xref: MESH:D008438 xref: NCIT:C34205 xref: SCTID:181326006 xref: UMLS:C0024949 {source="ncithesaurus:Maxillary_Artery"} xref: Wikipedia:Maxillary_artery is_a: UBERON:0001637 ! artery intersection_of: UBERON:0001637 ! artery intersection_of: RO:0002207 UBERON:0003118 ! directly develops from pharyngeal arch artery 1 relationship: RO:0002170 UBERON:0001070 ! connected to external carotid artery relationship: RO:0002207 UBERON:0003118 ! directly develops from pharyngeal arch artery 1 property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/3/39/Gray510.png" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001619 name: ophthalmic artery def: "The ophthalmic artery is a branch of the internal carotid artery which supplies branches to supply the eye and other structures in the orbit. It enters the orbit together with the Optic nerve through the Optic foramen/canal. [WP,modified]." [Wikipedia:Ophthalmic_artery] subset: human_reference_atlas subset: uberon_slim synonym: "arteria ophthalmica" RELATED OMO:0003011 [Wikipedia:Ophthalmic_artery] synonym: "opthalmic artery" RELATED [Wikipedia:Ophthalmic_artery] xref: AAO:0010497 xref: EHDAA2:0001300 xref: EHDAA:7363 xref: EMAPA:17007 xref: FMA:49868 xref: GAID:503 xref: MA:0002011 xref: MESH:D009880 xref: NCIT:C33216 xref: SCTID:181310005 xref: UMLS:C0029078 {source="ncithesaurus:Opthalmic_Artery"} xref: Wikipedia:Ophthalmic_artery xref: XAO:0000368 is_a: UBERON:0001637 ! artery relationship: RO:0002252 UBERON:0001532 ! connecting branch of internal carotid artery property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/c/ce/Gray514.png" xsd:anyURI property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/blood-vasculature-female/v1.3/assets/3d-vh-f-blood-vasculature.glb" xsd:anyURI property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/blood-vasculature-male/v1.3/assets/3d-vh-m-blood-vasculature.glb" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "ophthalmic artery" xsd:string [Term] id: UBERON:0001621 name: coronary artery def: "An artery that supplies the myocardium." [http://orcid.org/0000-0002-6601-2165, Wikipedia:Coronary_circulation#Coronary_anatomy] subset: efo_slim subset: pheno_slim subset: uberon_slim synonym: "coronary arterial tree" EXACT [] synonym: "coronary vessel" RELATED [ZFA:0005812] xref: BTO:0000290 xref: CALOHA:TS-0176 xref: EFO:0002551 xref: EMAPA:19160 xref: EV:0100383 xref: FMA:49893 xref: galen:CoronaryArtery xref: MA:0002453 xref: NCIT:C12843 xref: SCTID:181294004 xref: UMLS:C0205042 {source="ncithesaurus:Coronary_Artery"} xref: VHOG:0001557 xref: Wikipedia:Coronary_circulation#Coronary_anatomy xref: ZFA:0005812 is_a: UBERON:0003498 ! heart blood vessel is_a: UBERON:0004573 ! systemic artery relationship: RO:0020101 UBERON:0002349 ! vessel supplies blood to myocardium property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/4/46/Gray492.png" xsd:anyURI [Term] id: UBERON:0001622 name: lacrimal artery def: "The lacrimal artery arises close to the optic foramen, and is one of the largest branches derived from the ophthalmic artery: not infrequently it is given off before the artery enters the orbit. It accompanies the lacrimal nerve along the upper border of the Lateral Rectus, supplies the lacrimal gland. [WP,unvetted]." [Wikipedia:Lacrimal_artery] subset: human_reference_atlas subset: uberon_slim synonym: "a. lacrimalis" RELATED OMO:0003011 [Wikipedia:Lacrimal_artery] xref: EMAPA:37094 {source="MA:th"} xref: FMA:49927 xref: MA:0001988 xref: NCIT:C52948 xref: SCTID:369324002 xref: UMLS:C0226171 {source="ncithesaurus:Lacrimal_Artery"} xref: Wikipedia:Lacrimal_artery is_a: UBERON:0001637 ! artery intersection_of: UBERON:0001637 ! artery intersection_of: RO:0020101 UBERON:0001817 ! vessel supplies blood to lacrimal gland relationship: RO:0002252 UBERON:0001619 {source="FMA"} ! connecting branch of ophthalmic artery relationship: RO:0020101 UBERON:0001817 ! vessel supplies blood to lacrimal gland property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/c/ce/Gray514.png" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001628 name: posterior communicating artery def: "One of a pair of right-sided and left-sided blood vessels in the circle of Willis. It connects the three cerebral arteries of the same side. Anteriorly, it is one portion of the terminal trifurcation of the internal carotid artery. The anterior cerebral artery and the middle cerebral artery are the other two branches of the trifurcation. Posteriorly, it communicates with the posterior cerebral artery." [Wikipedia:Posterior_communicating_artery] subset: human_reference_atlas subset: uberon_slim subset: vertebrate_core synonym: "arteria cerebri communicans posterior" RELATED OMO:0003011 [Wikipedia:Posterior_communicating_artery] synonym: "caudal communicating segment" EXACT [ZFA:0005001] synonym: "PCA" RELATED [] synonym: "PCS" RELATED [] synonym: "posterior communicating segment of the basilar artery" EXACT [ZFA:0005001] xref: EHDAA2:0004518 xref: EHDAA:3352 xref: EMAPA:18600 xref: FMA:50084 xref: MA:0002023 xref: NCIT:C33357 xref: RETIRED_EHDAA2:0001487 xref: SCTID:181314001 xref: TAO:0005001 xref: UMLS:C0149559 {source="ncithesaurus:Posterior_Communicating_Artery"} xref: Wikipedia:Posterior_communicating_artery xref: ZFA:0005001 is_a: UBERON:0004573 ! systemic artery is_a: UBERON:0006347 ! communicating artery is_a: UBERON:0015212 ! lateral structure intersection_of: UBERON:0006347 ! communicating artery intersection_of: BFO:0000050 UBERON:0003709 ! part of circle of Willis intersection_of: RO:0002252 UBERON:0001532 ! connecting branch of internal carotid artery relationship: BFO:0000050 UBERON:0003709 ! part of circle of Willis relationship: BSPO:0000126 UBERON:0003709 {source="FMA-abduced-lr"} ! circle of Willis relationship: RO:0002252 UBERON:0001532 {source="FMA", source="ZFA"} ! connecting branch of internal carotid artery property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/2/2e/Circle_of_Willis_en.svg" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "posterior communicating artery" xsd:string [Term] id: UBERON:0001630 name: muscle organ def: "Organ consisting of a tissue made up of various elongated cells that are specialized to contract and thus to produce movement and mechanical work[GO]." [GO:0007517] subset: organ_slim subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "muscle" BROAD [ZFA:0005145] xref: EMAPA:37474 {source="MA:th"} xref: EV:0100146 xref: FMA:5022 xref: GAID:131 xref: galen:Muscle xref: MA:0000015 xref: SCTID:71616004 xref: TAO:0005145 xref: VHOG:0001245 xref: XAO:0000172 xref: ZFA:0005145 is_a: UBERON:0000062 ! organ is_a: UBERON:0005090 ! muscle structure intersection_of: UBERON:0000062 ! organ intersection_of: RO:0002473 UBERON:0002385 ! composed primarily of muscle tissue relationship: BFO:0000050 UBERON:0001015 ! part of musculature relationship: RO:0002473 UBERON:0002385 ! composed primarily of muscle tissue property_value: skos:prefLabel "muscle organ" xsd:string [Term] id: UBERON:0001637 name: artery def: "An epithelial tube or tree of tibes that transports blood away from the heart[modified from AEO definition]." [AEO:JB] subset: efo_slim subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "arterial subtree" EXACT [] synonym: "arterial system" RELATED [] synonym: "arterial tree organ part" EXACT [] synonym: "arterial vessel" RELATED [] synonym: "arteries" EXACT OMO:0003004 [TAO:0000005] xref: AAO:0010211 xref: AEO:0000208 xref: BTO:0000573 xref: CALOHA:TS-0054 xref: EFO:0000814 xref: EHDAA2:0003253 xref: EMAPA:35147 xref: EV:0100026 xref: FMA:50720 xref: GAID:468 xref: galen:Artery xref: MA:0000064 xref: MAT:0000034 xref: MESH:D001158 xref: MIAA:0000034 xref: NCIT:C12372 xref: SCTID:362877004 xref: TAO:0000005 xref: UMLS:C0003842 {source="ncithesaurus:Artery"} xref: VHOG:0001251 xref: Wikipedia:Artery xref: XAO:0000114 xref: ZFA:0000005 is_a: UBERON:0003509 ! arterial blood vessel relationship: channels_from UBERON:0000948 ! heart property_value: IAO:0000116 "Note that in FMA an artery is a tree, whereas AEO/JB defines it as a tube; FMA includes a separate class for what it calls the trunk. Classification in this ontology may currently (Jan 2012) represent a mix of both schemes, although we are gradually revising in the direction of the AEO scheme." xsd:string property_value: skos:prefLabel "artery" xsd:string [Term] id: UBERON:0001638 name: vein def: "Any of the tubular branching vessels that carry blood from the capillaries toward the heart." [Wikipedia:Vein] subset: efo_slim subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "vascular element" RELATED [EMAPA:th] synonym: "vena" RELATED OMO:0003011 [Wikipedia:Vein] synonym: "venae" RELATED OMO:0003004 [VHOG:0001743] synonym: "venous subtree" BROAD [] synonym: "venous tree organ part" EXACT [] synonym: "venous vessel" BROAD [] xref: AAO:0010212 xref: AEO:0000209 xref: BTO:0000234 xref: CALOHA:TS-1108 xref: EFO:0000816 xref: EHDAA2:0003254 xref: EMAPA:35906 xref: EV:0100031 xref: FMA:50723 xref: GAID:492 xref: galen:Vein xref: MA:0000067 xref: MAT:0000037 xref: MESH:D014680 xref: MIAA:0000037 xref: NCIT:C12814 xref: SCTID:181367001 xref: TAO:0000082 xref: UMLS:C0042449 {source="ncithesaurus:Vein"} xref: VHOG:0001743 xref: Wikipedia:Vein xref: XAO:0000115 xref: ZFA:0000082 is_a: UBERON:0003920 ! venous blood vessel intersection_of: UBERON:0003920 ! venous blood vessel intersection_of: channel_for UBERON:0013756 ! venous blood relationship: channel_for UBERON:0013756 ! venous blood relationship: channels_from UBERON:0001982 ! capillary property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/c/c2/Venous_system_en.svg" xsd:anyURI property_value: IAO:0000116 "TODO - check with MA - vein vs venous blood vessel" xsd:string property_value: skos:prefLabel "vein" xsd:string [Term] id: UBERON:0001639 name: hepatic portal vein def: "A portal vein that transports nutrients from the digestive tract to the liver[Kardong]." [http://sourceforge.net/tracker/?func=detail&aid=3091300&group_id=76834&atid=1205376, ISBN:0073040584, Wikipedia:Hepatic_portal_vein] subset: human_reference_atlas subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "hepatic portal tree" EXACT [] synonym: "HPV" RELATED [] synonym: "liver portal vein" EXACT [OBOL:automatic] synonym: "portal vein" RELATED INCONSISTENT [] synonym: "portal vein of liver" EXACT [OBOL:automatic] synonym: "primary hepatic portal vein" RELATED [ZFA:0005090] synonym: "primary hepatic portal veins" RELATED [] synonym: "vena portae hepatis" RELATED OMO:0003011 [Wikipedia:Hepatic_portal_vein] xref: AAO:0010214 xref: FMA:50735 xref: MA:0002132 xref: TAO:0005090 xref: VHOG:0000642 xref: Wikipedia:Hepatic_portal_vein xref: ZFA:0005090 is_a: UBERON:0002017 {source="MA"} ! portal vein relationship: BFO:0000050 UBERON:0010194 ! part of hepatic portal system relationship: channels_into UBERON:0002107 ! liver relationship: RO:0002131 UBERON:0002107 ! overlaps liver property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/3/33/Gray591.png" xsd:anyURI property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/blood-vasculature-female/v1.3/assets/3d-vh-f-blood-vasculature.glb" xsd:anyURI property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/blood-vasculature-male/v1.3/assets/3d-vh-m-blood-vasculature.glb" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "hepatic portal vein" xsd:string [Term] id: UBERON:0001640 name: celiac artery def: "The first major branch of the abdominal aorta." [Wikipedia:Celiac_artery] comment: dorsal aorta in Kardong subset: human_reference_atlas subset: pheno_slim subset: uberon_slim synonym: "arteria coeliaca" RELATED OMO:0003011 [Wikipedia:Celiac_artery] synonym: "arteria cœliaca" RELATED OMO:0003011 [Wikipedia:Celiac_artery] synonym: "celiac tree" EXACT [] synonym: "celiac trunk" RELATED [Wikipedia:Celiac_artery] synonym: "coeliac artery" EXACT [Wikipedia:Celiac_artery] synonym: "coeliac axis" RELATED [Wikipedia:Celiac_artery] synonym: "coeliac trunck" RELATED [Wikipedia:Celiac_artery] synonym: "coeliac trunk" RELATED [Wikipedia:Celiac_artery] synonym: "truncus coeliacus" RELATED OMO:0003011 [Wikipedia:Celiac_artery] synonym: "truncus cœliacus" RELATED OMO:0003011 [Wikipedia:Celiac_artery] xref: EHDAA2:0004519 xref: EMAPA:35202 xref: FMA:50737 xref: GAID:483 xref: MA:0001931 xref: MESH:D002445 xref: NCIT:C52846 xref: SCTID:181340007 xref: UMLS:C0007569 {source="ncithesaurus:Coeliac_Artery"} xref: Wikipedia:Celiac_artery is_a: UBERON:0012254 ! abdominal aorta artery relationship: indirectly_supplies UBERON:0000160 {source="ISBN:0073040584"} ! intestine relationship: indirectly_supplies UBERON:0000945 {source="ISBN:0073040584"} ! stomach relationship: indirectly_supplies UBERON:0002106 {source="ISBN:0073040584"} ! spleen relationship: indirectly_supplies UBERON:0002107 {source="ISBN:0073040584"} ! liver property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/6/65/Gray532.png" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "celiac artery" xsd:string [Term] id: UBERON:0001643 name: oculomotor nerve def: "Cranial nerve which connects the midbrain to the extra-ocular and intra-ocular muscles." [ISBN:0471209627, Wikipedia:Oculomotor_nerve] subset: human_reference_atlas subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "3n" BROAD OMO:0003000 [BIRNLEX:1646, NIFSTD:NeuroNames_abbrevSource] synonym: "CN-III" RELATED [] synonym: "cranial nerve III" RELATED [] synonym: "nerve III" RELATED [NeuroNames:488] synonym: "nervus oculomotorius" EXACT OMO:0003011 [Wikipedia:Oculomotor_nerve] synonym: "nervus oculomotorius [III]" EXACT OMO:0003011 [FMA:50864, FMA:TA] synonym: "occulomotor" RELATED [] synonym: "oculomotor III" EXACT [EHDAA2:0001284] synonym: "oculomotor III nerve" EXACT [] synonym: "oculomotor nerve [III]" EXACT [] synonym: "oculomotor nerve or its root" RELATED [BAMS:3n] synonym: "oculomotor nerve tree" EXACT [] synonym: "third cranial nerve" EXACT [] xref: AAO:0010468 xref: BAMS:3n xref: BAMS:IIIn xref: BIRNLEX:1646 xref: BM:MB-IIIN xref: EHDAA2:0001284 xref: EHDAA:3736 xref: EMAPA:17574 xref: FMA:50864 xref: GAID:829 xref: HBA:9316 xref: MA:0001095 xref: MBA:832 xref: MESH:D009802 xref: NCIT:C12758 xref: neuronames:488 {source="BIRNLEX:1646"} xref: SCTID:362456009 xref: TAO:0000405 xref: UMLS:C0028864 {source="BIRNLEX:1646", source="ncithesaurus:Oculomotor_Nerve"} xref: VHOG:0000692 xref: Wikipedia:Oculomotor_nerve xref: XAO:0003090 xref: ZFA:0000405 is_a: UBERON:0001785 ! cranial nerve intersection_of: UBERON:0001785 ! cranial nerve intersection_of: extends_fibers_into UBERON:0001715 ! oculomotor nuclear complex intersection_of: RO:0002134 UBERON:0001601 ! innervates extra-ocular muscle intersection_of: RO:0002134 UBERON:0011222 ! innervates intra-ocular muscle relationship: extends_fibers_into UBERON:0001715 ! oculomotor nuclear complex relationship: RO:0002134 UBERON:0001601 ! innervates extra-ocular muscle relationship: RO:0002134 UBERON:0011222 ! innervates intra-ocular muscle relationship: RO:0002202 UBERON:0010285 {source="Wikipedia"} ! develops from midbrain basal plate property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/6/69/Gray776.png" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "oculomotor nerve" xsd:string [Term] id: UBERON:0001645 name: trigeminal nerve def: "Cranial nerve that has three branches - the ophthalmic (supplying the skin of the nose and upper jaw), the maxillary and the mandibular (supplying the lower jaw)." [ISBN:0471209627, Wikipedia:Trigeminal_nerve] subset: efo_slim subset: human_reference_atlas subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "5n" BROAD OMO:0003000 [BIRNLEX:869, NIFSTD:NeuroNames_abbrevSource] synonym: "CN-V" RELATED [] synonym: "cranial nerve V" RELATED [] synonym: "fifth cranial nerve" EXACT [] synonym: "nerve V" RELATED [NeuroNames:549] synonym: "nervus trigeminus" EXACT OMO:0003011 [Wikipedia:Trigeminal_nerve] synonym: "nervus trigeminus" RELATED [BTO:0001072] synonym: "nervus trigeminus [v]" EXACT OMO:0003011 [FMA:50866, FMA:TA] synonym: "trigeminal nerve [V]" EXACT [] synonym: "trigeminal nerve tree" EXACT [] synonym: "trigeminal V" EXACT [EHDAA2:0002084] synonym: "trigeminal v nerve" EXACT [] synonym: "trigeminus" RELATED [BTO:0001072] xref: AAO:0010470 xref: BAMS:5n xref: BAMS:nV xref: BAMS:Vn xref: BIRNLEX:869 xref: BM:VN xref: BTO:0001072 xref: EFO:0001402 xref: EHDAA2:0002084 xref: EHDAA:3738 xref: EMAPA:17576 xref: FMA:50866 xref: GAID:726 xref: MA:0001100 xref: MBA:901 xref: MESH:D014276 xref: MFMO:0000093 xref: NCIT:C12806 xref: neuronames:549 {source="BIRNLEX:869"} xref: SCTID:362459002 xref: TAO:0000697 xref: UMLS:C0040996 {source="ncithesaurus:Trigeminal_Nerve", source="BIRNLEX:869"} xref: VHOG:0000704 xref: Wikipedia:Trigeminal_nerve xref: XAO:0003092 xref: ZFA:0000697 is_a: UBERON:0001785 ! cranial nerve intersection_of: UBERON:0001785 ! cranial nerve intersection_of: extends_fibers_into UBERON:0002925 ! trigeminal nucleus intersection_of: RO:0002134 UBERON:0000165 ! innervates mouth intersection_of: RO:0002134 UBERON:0011648 ! innervates jaw muscle intersection_of: RO:0002134 UBERON:1000021 ! innervates skin of face relationship: extends_fibers_into UBERON:0002925 ! trigeminal nucleus relationship: RO:0002134 UBERON:0000165 ! innervates mouth relationship: RO:0002134 UBERON:0011648 ! innervates jaw muscle relationship: RO:0002134 UBERON:1000021 ! innervates skin of face relationship: RO:0002254 UBERON:0005239 {source="Wikipedia"} ! has developmental contribution from basal plate metencephalon property_value: foaf:depiction "https://upload.wikimedia.org/wikipedia/commons/9/99/Gray778_Trigeminal.png" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "trigeminal nerve" xsd:string [Term] id: UBERON:0001647 name: facial nerve def: "Cranial nerve that branches into the supraorbital (supplying the skin of the eye region and the lateral line organs here), the palatine (to the roof of the buccal cavity), and the hyomandibular (dividing into the jugular and mental branches)." [ISBN:0471209627, Wikipedia:Facial_nerve] subset: human_reference_atlas subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "7n" BROAD OMO:0003000 [BIRNLEX:827, NIFSTD:NeuroNames_abbrevSource] synonym: "branchiomeric cranial nerve" EXACT [] synonym: "CN-VII" RELATED [] synonym: "cranial nerve VII" RELATED [] synonym: "face nerve" EXACT [OBOL:automatic] synonym: "facial nerve [VII]" EXACT [] synonym: "facial nerve or its root" RELATED [BAMS:7n] synonym: "facial nerve tree" EXACT [] synonym: "facial nerve/root" RELATED [BAMS:7n] synonym: "facial VII" EXACT [EHDAA2:0000489] synonym: "facial VII nerve" EXACT [] synonym: "nerve of face" EXACT [OBOL:automatic] synonym: "nerve VII" RELATED [NeuroNames:551] synonym: "nervus facialis" EXACT [ZFA:0000664] synonym: "nervus facialis" RELATED OMO:0003011 [Wikipedia:Facial_nerve] synonym: "nervus facialis [vii]" EXACT OMO:0003011 [FMA:50868, FMA:TA] synonym: "seventh cranial nerve" EXACT [] xref: AAO:0010472 xref: BAMS:7n xref: BAMS:nVII xref: BAMS:VIIn xref: BAMS:Viin xref: BIRNLEX:827 xref: BM:Pons-VIIN xref: EHDAA2:0000489 xref: EHDAA:3729 xref: EMAPA:17796 xref: FMA:50868 xref: GAID:719 xref: HBA:9328 xref: MA:0001091 xref: MBA:798 xref: MESH:D005154 xref: NCIT:C12714 xref: neuronames:551 {source="BIRNLEX:827"} xref: SCTID:362460007 xref: TAO:0000664 xref: UMLS:C0015462 {source="ncithesaurus:Facial_Nerve", source="BIRNLEX:827"} xref: VHOG:0000706 xref: Wikipedia:Facial_nerve xref: XAO:0003094 xref: ZFA:0000664 is_a: UBERON:0001785 ! cranial nerve is_a: UBERON:0010314 ! structure with developmental contribution from neural crest intersection_of: UBERON:0001021 ! nerve intersection_of: extends_fibers_into UBERON:0000127 ! facial nucleus intersection_of: RO:0002134 UBERON:0001577 ! innervates facial muscle relationship: BFO:0000050 UBERON:0001033 {source="ZFA"} ! part of gustatory system relationship: extends_fibers_into UBERON:0000127 ! facial nucleus relationship: RO:0002134 UBERON:0001577 ! innervates facial muscle relationship: RO:0002254 UBERON:0003066 {source="Wikipedia"} ! has developmental contribution from pharyngeal arch 2 relationship: RO:0002254 UBERON:0005239 {source="Wikipedia"} ! has developmental contribution from basal plate metencephalon property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/1/1f/Cranial_nerve_VII.svg" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "facial nerve" xsd:string [Term] id: UBERON:0001648 name: vestibulocochlear nerve def: "Cranial nerve that transmits sound and equilibrium (balance) information from the inner ear to the brain." [ISBN:0471209627, Wikipedia:Vestibulocochlear_nerve] subset: human_reference_atlas subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "8n" BROAD OMO:0003000 [BIRNLEX:890, NIFSTD:NeuroNames_abbrevSource] synonym: "acoustic nerve" EXACT [FMA:50869] synonym: "acoustic nerve (Crosby)" EXACT [] synonym: "acoustic VIII nerve" EXACT [] synonym: "CN-VIII" EXACT [] synonym: "cochlear-vestibular nerve" EXACT [] synonym: "cochleovestibular nerve" EXACT [] synonym: "cranial nerve VIII" EXACT [] synonym: "eighth cranial nerve" EXACT [] synonym: "nervus octavus" RELATED OMO:0003011 [NeuroNames:553] synonym: "nervus statoacusticus" RELATED OMO:0003011 [NeuroNames:553] synonym: "nervus vestibulocochlearis" RELATED [BTO:0003490] synonym: "nervus vestibulocochlearis [viii]" EXACT OMO:0003011 [FMA:50869, FMA:TA] synonym: "octaval nerve" RELATED [] synonym: "stato-acoustic nerve" EXACT [] synonym: "statoacoustic nerve" RELATED [] synonym: "vestibulocochlear nerve [VIII]" EXACT [] synonym: "vestibulocochlear nerve tree" EXACT [] synonym: "vestibulocochlear VIII nerve" EXACT [] synonym: "VIII nerve" EXACT [] synonym: "VIIIth cranial nerve" EXACT [] xref: AAO:0010473 xref: BAMS:8n xref: BAMS:nVIII xref: BAMS:VIIIn xref: BIRNLEX:890 xref: BTO:0003490 xref: EHDAA2:0002194 xref: EMAPA:17801 xref: FMA:50869 xref: GAID:839 xref: HBA:9331 xref: MA:0001109 xref: MBA:933 xref: MESH:D000159 xref: NCIT:C12996 xref: neuronames:553 {source="BIRNLEX:890"} xref: SCTID:180945001 xref: TAO:0000247 xref: UMLS:C0001162 {source="BIRNLEX:890", source="ncithesaurus:Vestibulocochlear_Nerve"} xref: UMLS:C1278835 {source="BIRNLEX:890"} xref: VHOG:0000695 xref: Wikipedia:Vestibulocochlear_nerve xref: XAO:0003095 xref: ZFA:0000247 is_a: UBERON:0001785 ! cranial nerve is_a: UBERON:0004121 ! ectoderm-derived structure intersection_of: UBERON:0001785 ! cranial nerve intersection_of: extends_fibers_into UBERON:0001720 ! cochlear nucleus intersection_of: RO:0002134 UBERON:0001844 ! innervates cochlea relationship: BFO:0000050 UBERON:0002105 ! part of vestibulo-auditory system relationship: extends_fibers_into UBERON:0001720 ! cochlear nucleus relationship: RO:0002134 UBERON:0001844 ! innervates cochlea relationship: RO:0002202 UBERON:0003069 {source="ISBN:0471888893"} ! develops from otic placode property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/7/7d/Gray789.png" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "vestibulocochlear nerve" xsd:string [Term] id: UBERON:0001649 name: glossopharyngeal nerve def: "Cranial nerve that branches into the ramus communicans (to the skin), the pretrematic (to the walls of the pharynx and mouth, viscero-sensory fibers), and the larval post-trematic branch (lost in the adult)." [ISBN:0471209627, Wikipedia:Glossopharyngeal_nerve] subset: human_reference_atlas subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "9n" BROAD OMO:0003000 [BIRNLEX:899, NIFSTD:NeuroNames_abbrevSource] synonym: "CN-IX" RELATED OMO:0003000 [] synonym: "cranial nerve IX" RELATED [] synonym: "glossopharyngeal IX" EXACT [EHDAA2:0000709] synonym: "glossopharyngeal IX nerve" EXACT [] synonym: "glossopharyngeal nerve [IX]" EXACT [] synonym: "glossopharyngeal nerve tree" EXACT [] synonym: "nerve IX" RELATED [NeuroNames:701] synonym: "nervus glossopharyngeus" EXACT [ZFA:0000668] synonym: "nervus glossopharyngeus" RELATED OMO:0003011 [Wikipedia:Glossopharyngeal_nerve] synonym: "nervus glossopharyngeus [ix]" EXACT OMO:0003011 [FMA:50870, FMA:TA] synonym: "ninth cranial nerve" EXACT [] xref: AAO:0010474 xref: BAMS:9n xref: BAMS:IXn xref: BIRNLEX:899 xref: BTO:0004979 xref: EHDAA2:0000709 xref: EHDAA:3733 xref: EMAPA:17268 xref: FMA:50870 xref: GAID:827 xref: MA:0001093 xref: MBA:808 xref: MESH:D005930 xref: NCIT:C12723 xref: neuronames:701 {source="BIRNLEX:899"} xref: SCTID:362465002 xref: TAO:0000668 xref: UMLS:C0017679 {source="BIRNLEX:899", source="ncithesaurus:Glossopharyngeal_Nerve"} xref: UMLS:C1305752 {source="BIRNLEX:899"} xref: VHOG:0000701 xref: Wikipedia:Glossopharyngeal_nerve xref: XAO:0003096 xref: ZFA:0000668 is_a: UBERON:0001785 ! cranial nerve relationship: BFO:0000050 UBERON:0001033 ! part of gustatory system relationship: extends_fibers_into UBERON:0001896 ! medulla oblongata relationship: RO:0002134 UBERON:0001727 ! innervates taste bud relationship: RO:0002134 UBERON:0006562 ! innervates pharynx relationship: RO:0002254 UBERON:0005239 ! has developmental contribution from basal plate metencephalon property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/5/5e/Gray791.png" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "glossopharyngeal nerve" xsd:string [Term] id: UBERON:0001650 name: hypoglossal nerve def: "Cranial nerve that innervates the muscles of the tongue." [http://orcid.org/0000-0002-6601-2165, ISBN:080184780X, VHOG:0000693] subset: human_reference_atlas subset: pheno_slim subset: uberon_slim synonym: "12n" BROAD OMO:0003000 [BIRNLEX:820, NIFSTD:NeuroNames_abbrevSource] synonym: "CN-XII" RELATED [VHOG:0000693] synonym: "cranial nerve XII" EXACT [BIRNLEX:820] synonym: "hypoglossal nerve [XII]" EXACT [] synonym: "hypoglossal nerve tree" EXACT [] synonym: "hypoglossal nerve/ root" RELATED [BAMS:12n] synonym: "hypoglossal XII" EXACT [EHDAA2:0000798] synonym: "hypoglossal XII nerve" EXACT [] synonym: "nerve XII" RELATED [NeuroNames:704] synonym: "nervi hypoglossalis" RELATED OMO:0003011 [NeuroNames:704] synonym: "nervus hypoglossus" RELATED OMO:0003011 [Wikipedia:Hypoglossal_nerve] synonym: "nervus hypoglossus [xii]" EXACT OMO:0003011 [FMA:50871, FMA:TA] synonym: "twelfth cranial nerve" EXACT [] xref: AAO:0010477 xref: BAMS:12n xref: BAMS:nXII xref: BAMS:XIIn xref: BIRNLEX:820 xref: BTO:0003386 xref: EHDAA2:0000798 xref: EHDAA:2859 xref: EMAPA:17269 xref: FMA:50871 xref: GAID:828 xref: MA:0001094 xref: MBA:813 xref: MESH:D007002 xref: NCIT:C12732 xref: neuronames:704 {source="BIRNLEX:820"} xref: SCTID:362471008 xref: UMLS:C0020614 {source="BIRNLEX:820", source="ncithesaurus:Hypoglossal_Nerve"} xref: VHOG:0000693 xref: Wikipedia:Hypoglossal_nerve xref: XAO:0004215 is_a: UBERON:0001785 ! cranial nerve intersection_of: UBERON:0001785 ! cranial nerve intersection_of: extends_fibers_into UBERON:0002871 ! hypoglossal nucleus intersection_of: RO:0002134 UBERON:0000378 ! innervates tongue muscle relationship: extends_fibers_into UBERON:0002871 ! hypoglossal nucleus relationship: RO:0002134 UBERON:0001571 ! innervates genioglossus muscle relationship: RO:0002134 UBERON:0001572 ! innervates hyoglossus muscle property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/e/ef/Gray794.png" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "hypoglossal nerve" xsd:string [Term] id: UBERON:0001651 name: right pulmonary artery def: "The pulmonary artery that supplies the right lung." [UBERON:cjm] subset: human_reference_atlas subset: uberon_slim synonym: "arteria pulmonalis dextra" RELATED OMO:0003011 [Wikipedia:Right_pulmonary_artery] synonym: "right main pulmonary artery" EXACT [] synonym: "right pulmonary arterial tree" EXACT [] xref: EMAPA:37378 {source="MA:th"} xref: FMA:50872 xref: galen:RightPulmonaryArtery xref: MA:0002500 xref: NCIT:C33489 xref: SCTID:244235003 xref: UMLS:C0923924 {source="ncithesaurus:Right_Pulmonary_Artery"} xref: Wikipedia:Right_pulmonary_artery is_a: UBERON:0001637 ! artery intersection_of: UBERON:0001637 ! artery intersection_of: RO:0020101 UBERON:0002167 ! vessel supplies blood to right lung relationship: RO:0002170 UBERON:0002333 ! connected to pulmonary trunk relationship: RO:0020101 UBERON:0002167 ! vessel supplies blood to right lung property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/f/f6/Gray504.png" xsd:anyURI property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/blood-vasculature-female/v1.3/assets/3d-vh-f-blood-vasculature.glb" xsd:anyURI property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/blood-vasculature-male/v1.3/assets/3d-vh-m-blood-vasculature.glb" xsd:anyURI property_value: foaf:depiction "https://upload.wikimedia.org/wikipedia/commons/d/db/Alveoli_diagram.png" xsd:anyURI property_value: IAO:0000116 "TODO - add class 'pulmonary artery tree organ'" xsd:string property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "right pulmonary artery" xsd:string [Term] id: UBERON:0001652 name: left pulmonary artery def: "The pulmonary artery that supplies the left lung." [UBERON:cjm] subset: human_reference_atlas subset: uberon_slim synonym: "arteria pulmonalis sinistra" RELATED OMO:0003011 [Wikipedia:Left_pulmonary_artery] synonym: "left main pulmonary artery" EXACT [] synonym: "left pulmonary arterial tree" EXACT [] xref: EMAPA:37097 {source="MA:th"} xref: FMA:50873 xref: galen:LeftPulmonaryArtery xref: MA:0002032 xref: NCIT:C32971 xref: SCTID:244234004 xref: UMLS:C0923925 {source="ncithesaurus:Left_Pulmonary_Artery"} xref: Wikipedia:Left_pulmonary_artery is_a: UBERON:0001637 ! artery intersection_of: UBERON:0001637 ! artery intersection_of: RO:0020101 UBERON:0002168 ! vessel supplies blood to left lung relationship: RO:0002170 UBERON:0002333 ! connected to pulmonary trunk relationship: RO:0020101 UBERON:0002168 ! vessel supplies blood to left lung property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/f/f6/Gray504.png" xsd:anyURI property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/blood-vasculature-female/v1.3/assets/3d-vh-f-blood-vasculature.glb" xsd:anyURI property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/blood-vasculature-male/v1.3/assets/3d-vh-m-blood-vasculature.glb" xsd:anyURI property_value: foaf:depiction "https://upload.wikimedia.org/wikipedia/commons/d/db/Alveoli_diagram.png" xsd:anyURI property_value: IAO:0000116 "TODO - add class 'pulmonary artery tree organ'" xsd:string property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "left pulmonary artery" xsd:string [Term] id: UBERON:0001653 name: facial vein def: "The anterior facial vein (facial vein) commences at the side of the root of the nose, and is a direct continuation of the angular vein where it also receives a small nasal branch. It lies behind the facial artery and follows a less tortuous course. It receives blood from the external palatine vein before it either joins the anterior branch of the retromandibular vein to form the common facial vein, or drains directly into the internal jugular vein. [WP,unvetted]." [Wikipedia:Facial_vein] subset: human_reference_atlas subset: uberon_slim synonym: "anterior facial vein" RELATED INCONSISTENT [Wikipedia:Facial_vein] synonym: "face vein" EXACT [OBOL:automatic] synonym: "vein of face" EXACT [OBOL:automatic] synonym: "vena facialis anterior" RELATED OMO:0003011 [Wikipedia:Facial_vein] xref: AAO:0010513 xref: EMAPA:19220 xref: FMA:50874 xref: MA:0002115 xref: NCIT:C32579 xref: SCTID:181374006 xref: UMLS:C0226532 {source="ncithesaurus:Facial_Vein"} xref: Wikipedia:Facial_vein is_a: UBERON:0003496 ! head blood vessel is_a: UBERON:0009141 ! craniocervical region vein relationship: BFO:0000050 UBERON:0001456 ! part of face relationship: RO:0002376 UBERON:0001586 {source="FMA"} ! tributary of internal jugular vein property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/8/8c/Gray557.png" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "facial vein" xsd:string [Term] id: UBERON:0001663 name: cerebral vein def: "The cerebral veins are divisible into external and internal groups according to the outer surfaces or the inner parts of the hemispheres they drain into. The external veins are the superior cerebral veins, inferior cerebral veins, and middle cerebral vein. [WP,unvetted]." [Wikipedia:Cerebral_veins] subset: pheno_slim synonym: "venae cerebri" RELATED OMO:0003011 [Wikipedia:Cerebral_veins] synonym: "venae encephali" RELATED OMO:0003011 [Wikipedia:Cerebral_veins] xref: EMAPA:37140 {source="MA:th"} xref: FMA:50981 xref: GAID:530 xref: MA:0002096 xref: MESH:D002550 xref: NCIT:C53037 xref: SCTID:244392000 xref: UMLS:C0007797 {source="ncithesaurus:Cerebral_Vein"} xref: Wikipedia:Cerebral_veins xref: XAO:0004160 is_a: UBERON:0001638 ! vein is_a: UBERON:0003499 ! brain blood vessel intersection_of: UBERON:0001638 ! vein intersection_of: RO:0020102 UBERON:0001893 ! vessel drains blood from telencephalon relationship: BFO:0000050 UBERON:0001893 ! part of telencephalon relationship: RO:0020102 UBERON:0001893 ! vessel drains blood from telencephalon property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/9/9f/Gray568.png" xsd:anyURI property_value: skos:prefLabel "cerebral vein" xsd:string [Term] id: UBERON:0001668 name: cerebellar vein def: "A vein that drains the cerebellum." [http://orcid.org/0000-0002-6601-2165] synonym: "cerebellum vein" EXACT [OBOL:automatic] synonym: "epencephalon-1 vein" EXACT [OBOL:automatic] synonym: "vein of cerebellum" EXACT [OBOL:automatic] synonym: "vein of epencephalon-1" EXACT [OBOL:automatic] xref: EMAPA:37139 {source="MA:th"} xref: FMA:51227 xref: MA:0002093 xref: NCIT:C53032 xref: SCTID:40693009 xref: UMLS:C0226601 {source="ncithesaurus:Cerebellar_Vein"} xref: Wikipedia:Cerebellar_veins is_a: UBERON:0001638 ! vein intersection_of: UBERON:0001638 ! vein intersection_of: RO:0020102 UBERON:0002037 ! vessel drains blood from cerebellum relationship: RO:0020102 UBERON:0002037 ! vessel drains blood from cerebellum property_value: skos:prefLabel "cerebellar vein" xsd:string [Term] id: UBERON:0001675 name: trigeminal ganglion def: "The cranial ganglion that is associated with and extends fibers into the trigeminal nerve." [http://orcid.org/0000-0002-6601-2165, http://www.ncbi.nlm.nih.gov/books/NBK53171, https://github.com/obophenotype/uberon/issues/693] subset: efo_slim subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "5th ganglion" EXACT [ZFA:0000295] synonym: "fifth ganglion" EXACT [ZFA:0000295] synonym: "fused trigeminal ganglion" NARROW SENSU [NCBITaxon:32524] synonym: "ganglion of trigeminal complex" EXACT [http://orcid.org/0000-0002-6601-2165] synonym: "ganglion of trigeminal nerve" RELATED [BTO:0001231] synonym: "ganglion semilunare" RELATED OMO:0003011 [Wikipedia:Trigeminal_ganglion] synonym: "ganglion trigeminale" RELATED OMO:0003011 [BTO:0001231, Wikipedia:Trigeminal_ganglion] synonym: "Gasser's ganglion" RELATED [BTO:0001231] synonym: "Gasserian ganglia" RELATED OMO:0003004 [Wikipedia:Trigeminal_ganglion] synonym: "Gasserian ganglion" EXACT [Wikipedia:Trigeminal_ganglion] synonym: "gV" RELATED [] synonym: "semilunar ganglion" EXACT [ISBN:0471888893] synonym: "trigeminal ganglia" RELATED OMO:0003004 [] synonym: "trigeminal V ganglion" EXACT [MA:0001080] synonym: "trigeminus ganglion" RELATED [] xref: AAO:0011107 xref: BAMS:5Gn xref: BAMS:GV xref: BTO:0001231 xref: EFO:0000903 xref: EHDAA2:0002085 xref: EHDAA:2113 xref: EMAPA:16797 xref: FMA:52618 xref: GAID:725 xref: MA:0001080 xref: MAT:0000511 xref: MESH:D012668 xref: NCIT:C62642 xref: neuronames:1402 xref: SCTID:244449009 xref: TAO:0000295 xref: UMLS:C0040995 {source="ncithesaurus:Trigeminal_Ganglion"} xref: VHOG:0000694 xref: Wikipedia:Trigeminal_ganglion xref: XAO:0000427 xref: XAO:0000428 xref: ZFA:0000295 is_a: UBERON:0001714 ! cranial ganglion is_a: UBERON:0001800 {source="ncithesaurus"} ! sensory ganglion is_a: UBERON:0004121 ! ectoderm-derived structure intersection_of: UBERON:0001714 ! cranial ganglion intersection_of: extends_fibers_into UBERON:0001645 ! trigeminal nerve relationship: extends_fibers_into UBERON:0001645 ! trigeminal nerve relationship: RO:0002495 UBERON:0006304 {source="Bgee:AN"} ! immediate transformation of future trigeminal ganglion property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/6/69/Gray776.png" xsd:anyURI property_value: IAO:0000116 "consider renaming this 'trigeminal ganglion complex'. The complex may be fused (amniotes) partially fused (xenopus) or separate (sharks)" xsd:string property_value: skos:prefLabel "trigeminal ganglion" xsd:string property_value: terms:contributor https://orcid.org/0000-0001-9114-8737 property_value: terms:contributor https://orcid.org/0000-0002-6601-2165 property_value: terms:contributor https://orcid.org/0000-0003-3308-6245 [Term] id: UBERON:0001676 name: occipital bone def: "The bone at the lower, posterior part of the skull." [ISBN:0-683-40008-8, MP:0005269] subset: human_reference_atlas subset: pheno_slim subset: uberon_slim synonym: "occipital complex" RELATED [http://palaeos.com/vertebrates/bones/braincase/occiput.html] synonym: "occipital squama" RELATED [] synonym: "os occipitale" RELATED OMO:0003011 [Wikipedia:Occipital_bone] xref: EMAPA:25112 xref: FMA:52735 xref: GAID:227 xref: MA:0001468 xref: MESH:D009777 xref: NCIT:C12757 xref: SCTID:181796003 xref: UMLS:C0028784 {source="ncithesaurus:Occipital_Bone"} xref: Wikipedia:Occipital_bone is_a: UBERON:0010428 {source="FMA"} ! flat bone is_a: UBERON:0011164 ! neurocranium bone relationship: BFO:0000050 UBERON:0005902 {source="FMA"} ! part of occipital region relationship: RO:0002131 UBERON:0002241 ! overlaps chondrocranium relationship: RO:0002131 UBERON:0003113 ! overlaps dermatocranium relationship: RO:0002162 NCBITaxon:117570 {source="WP"} ! in taxon Teleostomi relationship: RO:0002202 UBERON:0003089 {source="PMID:11523816"} ! develops from sclerotome relationship: RO:0002221 UBERON:0003687 ! surrounds foramen magnum property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/2/27/Gray194.png" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "occipital bone" xsd:string [Term] id: UBERON:0001677 name: sphenoid bone def: "An unpaired bone situated at the base of the skull in front of the temporal bone and basilar part of the occipital bone. The sphenoid bone is one of the seven bones that articulate to form the orbit. Its shape somewhat resembles that of a butterfly or bat with its wings extended." [Wikipedia:Sphenoid_bone] subset: human_reference_atlas subset: pheno_slim subset: uberon_slim synonym: "butterfly bone" RELATED [Wikipedia:Sphenoid_bone] synonym: "os sphenoidale" EXACT OMO:0003011 [FMA:52736, FMA:TA] synonym: "os sphenoidale" RELATED OMO:0003011 [Wikipedia:Sphenoid_bone] synonym: "os sphenoidum" RELATED [Wikipedia:Sphenoid_bone] synonym: "sphenoid" EXACT [] synonym: "sphenoid complex" RELATED [] synonym: "sphenoidal bone" EXACT [] xref: CALOHA:TS-2343 xref: EMAPA:18340 xref: FMA:52736 xref: GAID:230 xref: MA:0001472 xref: MESH:D013100 xref: NCIT:C12790 xref: SCTID:272676008 xref: UMLS:C0037884 {source="ncithesaurus:Sphenoid_Bone"} xref: Wikipedia:Sphenoid_bone is_a: UBERON:0002513 ! endochondral bone is_a: UBERON:0003462 ! facial bone is_a: UBERON:0008193 {source="FMA"} ! pneumatized bone is_a: UBERON:0015060 ! sphenoid endochondral element intersection_of: UBERON:0015060 ! sphenoid endochondral element intersection_of: RO:0002473 UBERON:0002481 ! composed primarily of bone tissue relationship: RO:0002131 UBERON:0002241 ! overlaps chondrocranium relationship: RO:0002131 UBERON:0003113 ! overlaps dermatocranium relationship: RO:0002131 UBERON:0008895 ! overlaps splanchnocranium relationship: RO:0002202 UBERON:0009193 {source="cjm"} ! develops from sphenoid cartilage element property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/6/66/Illu_cranial_bones2.jpg" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "sphenoid bone" xsd:string [Term] id: UBERON:0001678 name: temporal bone def: "The large, irregular bone located at the base and side of the skull; consists of three parts at birth: squamous, tympanic, and petrous." [ISBN:0-683-40008-8, MP:0005272] subset: human_reference_atlas subset: pheno_slim subset: uberon_slim synonym: "os temporale" RELATED OMO:0003011 [Wikipedia:Temporal_bone] xref: EHDAA:6035 xref: EMAPA:17682 xref: FMA:52737 xref: GAID:232 xref: MA:0001476 xref: MESH:D013701 xref: NCIT:C12797 xref: SCTID:181795004 xref: UMLS:C0039484 {source="ncithesaurus:Temporal_Bone"} xref: VHOG:0000800 xref: Wikipedia:Temporal_bone is_a: UBERON:0008193 {source="FMA"} ! pneumatized bone relationship: RO:0002131 UBERON:0002241 ! overlaps chondrocranium relationship: RO:0002131 UBERON:0003113 ! overlaps dermatocranium relationship: RO:0002131 UBERON:0008895 ! overlaps splanchnocranium property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/6/66/Illu_cranial_bones2.jpg" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "temporal bone" xsd:string [Term] id: UBERON:0001679 name: ethmoid bone def: "A bone in the skull that separates the nasal cavity from the brain. As such, it is located at the roof of the nose, between the two orbits. The cubical bone is lightweight due to a spongy construction. The ethmoid bone is one of the bones that makes up the orbit of the eye[WP]." [Wikipedia:Ethmoid_bone] subset: human_reference_atlas subset: pheno_slim subset: uberon_slim synonym: "ethmoid" EXACT [FMA:52740] synonym: "ethmoidal bone" EXACT [MP:0000101] synonym: "os ethmoidale" EXACT OMO:0003011 [FMA:52740, FMA:TA, Wikipedia:Ethmoid] xref: BTO:0004140 xref: EMAPA:19018 xref: FMA:52740 xref: GAID:212 xref: MA:0001483 xref: MESH:D005004 xref: NCIT:C12711 xref: SCTID:272674006 xref: UMLS:C0015027 {source="ncithesaurus:Ethmoid_Bone"} xref: VHOG:0001317 xref: Wikipedia:Ethmoid_bone is_a: UBERON:0002513 {source="ISBN:0073040584"} ! endochondral bone is_a: UBERON:0003462 ! facial bone is_a: UBERON:0011164 ! neurocranium bone relationship: BFO:0000050 UBERON:0002517 ! part of basicranium relationship: BFO:0000050 UBERON:0011241 ! part of ethmoid region relationship: RO:0002202 UBERON:0006227 {evidence="definitional"} ! develops from ethmoid bone primordium relationship: RO:0002433 UBERON:0011156 ! contributes to morphology of facial skeleton property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/6/66/Illu_cranial_bones2.jpg" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "ethmoid bone" xsd:string [Term] id: UBERON:0001685 name: hyoid bone def: "A horseshoe shaped bone situated in the anterior midline of the neck between the chin and the thyroid cartilage. The hyoid bone provides attachment to the muscles of the floor of the mouth and the tongue above, the larynx below, and the epiglottis and pharynx behind. [WP,modified]." [Wikipedia:Hyoid_bone] subset: human_reference_atlas subset: pheno_slim subset: uberon_slim synonym: "hyoid" RELATED [Wikipedia:Hyoid_bone] synonym: "hyoid bone" RELATED [Wikipedia:Hyoid_bone] synonym: "hyoideum" RELATED [Wikipedia:Hyoid_bone] synonym: "lingual bone" RELATED [Wikipedia:Hyoid_bone] synonym: "os hyoideum" RELATED OMO:0003011 [Wikipedia:Hyoid_bone] xref: AAO:0000684 xref: EMAPA:18650 xref: FMA:52749 xref: GAID:197 xref: MA:0001484 xref: MESH:D006928 xref: NCIT:C32752 xref: SCTID:263352000 xref: UMLS:C0020417 {source="ncithesaurus:Hyoid_Bone"} xref: VHOG:0001325 xref: Wikipedia:Hyoid_bone is_a: UBERON:0008001 {source="FMA"} ! irregular bone relationship: BFO:0000050 UBERON:0010272 ! part of hyoid apparatus relationship: RO:0002254 UBERON:0003066 {source="Wikipedia"} ! has developmental contribution from pharyngeal arch 2 relationship: RO:0002254 UBERON:0003114 {source="Wikipedia"} ! has developmental contribution from pharyngeal arch 3 property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/1/1f/Gray186.png" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "hyoid bone" xsd:string [Term] id: UBERON:0001686 name: auditory ossicle bone def: "One of 3 small bones contained within the middle ear space and serve to transmit sounds from the air to the fluid-filled labyrinth. The absence of the auditory ossicles would constitute a moderate-to-severe hearing loss. The term 'ossicles' literally means 'tiny bones' and commonly refers to the auditory ossicles, though the term may refer to any small bone throughout the body. [WP,unvetted]." [https://github.com/obophenotype/uberon/issues/91, Wikipedia:Auditory_ossicle] subset: pheno_slim subset: uberon_slim synonym: "auditory bone" EXACT [] synonym: "auditory ossicle" RELATED [MA:0000254] synonym: "ear bone" RELATED [MA:0000254] synonym: "ear ossicle" RELATED [] synonym: "ear ossicles" RELATED OMO:0003004 [] synonym: "middle ear bone" RELATED [] synonym: "middle ear ossicle" EXACT [MP:0005105] synonym: "ossicle" BROAD [EMAPA:17824, Wikipedia:Auditory_ossicle] synonym: "ossicle of ear" RELATED [] synonym: "ossicle of inner ear" RELATED [] synonym: "ossicular chain" RELATED OMO:0003004 [] xref: AAO:0011015 xref: EHDAA2:0001183 xref: EHDAA:5697 xref: EMAPA:17824 xref: EV:0100360 xref: FMA:52750 xref: MA:0000254 xref: NCIT:C32164 xref: SCTID:181184001 xref: UMLS:C0013450 {source="ncithesaurus:Auditory_Ossicle"} xref: VHOG:0000461 xref: Wikipedia:Auditory_ossicle xref: XAO:0000214 is_a: UBERON:0003457 ! head bone is_a: UBERON:0035130 ! auditory ossicle endochondral element intersection_of: UBERON:0035130 ! auditory ossicle endochondral element intersection_of: RO:0002473 UBERON:0002481 ! composed primarily of bone tissue property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/b/b0/Illu_auditory_ossicles.jpg" xsd:anyURI property_value: IAO:0000116 "This should probably be restricted to mammals - the AAO/XAO structures may group non-homologous structures [Wikipedia:Evolution_of_mammalian_auditory_ossicles] see https://github.com/seger/aao/issues/5." xsd:string property_value: terms:contributor https://orcid.org/0000-0002-6601-2165 [Term] id: UBERON:0001690 name: ear def: "Sense organ in vertebrates that is specialized for the detection of sound, and the maintenance of balance. Includes the outer ear and middle ear, which collect and transmit sound waves; and the inner ear, which contains the organs of balance and (except in fish) hearing. Also includes the pinna, the visible part of the outer ear, present in some mammals." [GO:0042471, Wikipedia:Ear] subset: efo_slim subset: organ_slim subset: pheno_slim subset: uberon_slim synonym: "auditory apparatus" RELATED [] synonym: "auris" RELATED [BTO:0000368] xref: AAO:0011014 xref: BIRNLEX:1062 xref: BTO:0000368 xref: CALOHA:TS-1165 xref: EFO:0000826 xref: EHDAA2:0000423 xref: EHDAA:502 xref: EMAPA:16193 xref: EV:0100353 xref: FMA:52780 xref: GAID:62 xref: galen:Ear xref: MA:0000236 xref: MAT:0000138 xref: MESH:D004423 xref: MIAA:0000138 xref: NCIT:C12394 xref: SCTID:1910005 xref: UMLS:C0013443 {source="ncithesaurus:Ear", source="BIRNLEX:1062"} xref: UMLS:C0521421 {source="BIRNLEX:1062"} xref: VHOG:0000330 xref: Wikipedia:Ear xref: XAO:0000189 is_a: UBERON:0000020 ! sense organ is_a: UBERON:0010314 ! structure with developmental contribution from neural crest relationship: BFO:0000050 UBERON:0000033 ! part of head relationship: BFO:0000050 UBERON:0002105 ! part of vestibulo-auditory system relationship: RO:0002215 GO:0050910 ! capable of detection of mechanical stimulus involved in sensory perception of sound property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/b/b8/Ear.jpg" xsd:anyURI property_value: skos:prefLabel "ear" xsd:string [Term] id: UBERON:0001691 name: external ear def: "Part of the ear external to the tympanum (eardrum). It typically consists of a tube (the external auditory meatus) that directs sound waves on to the tympanum, and may also include the external pinna, which extends beyond the skull[GO]." [GO:0042473, Wikipedia:External_ear] subset: efo_slim subset: pheno_slim subset: uberon_slim synonym: "auricular region" BROAD [] synonym: "auricular region of head" EXACT [] synonym: "auris externa" RELATED [BTO:0002100] synonym: "outer ear" EXACT [MA:0000258] xref: AAO:0011037 xref: BIRNLEX:1705 xref: BTO:0002100 xref: EFO:0004221 xref: EHDAA2:0000462 xref: EHDAA:3786 xref: EMAPA:16991 xref: EV:0100354 xref: FMA:52781 xref: GAID:104 xref: MA:0000258 xref: MAT:0000147 xref: MESH:D004431 xref: MIAA:0000147 xref: NCIT:C12292 xref: SCTID:420893000 xref: UMLS:C0013453 {source="ncithesaurus:External_Ear", source="BIRNLEX:1705"} xref: UMLS:C1269548 {source="BIRNLEX:1705"} xref: VHOG:0000311 xref: Wikipedia:External_ear xref: XAO:0000190 is_a: UBERON:0001444 ! subdivision of head is_a: UBERON:0015212 ! lateral structure relationship: BFO:0000050 UBERON:0001690 ! part of ear relationship: BSPO:0000126 UBERON:0000033 ! head relationship: RO:0002162 NCBITaxon:32523 ! in taxon Tetrapoda relationship: RO:0002433 UBERON:0000033 ! contributes to morphology of head relationship: RO:0002433 UBERON:0001690 ! contributes to morphology of ear property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/2/29/Gray907.png" xsd:anyURI property_value: RO:0002161 NCBITaxon:9709 {source="Wikipedia"} [Term] id: UBERON:0001694 name: petrous part of temporal bone def: "The petrous portion of the temporal bone or pyramid is pyramidal and is wedged in at the base of the skull between the sphenoid and occipital bones. Directed medially, forward, and a little upward, it presents for examination a base, an apex, three surfaces, and three angles, and contains, in its interior, the essential parts of the organ of hearing. The petrous portion is among the most basal elements of the skull and forms part of the endocranium.[WP,unvetted]." [Wikipedia:Petrous_part_of_the_temporal_bone] subset: uberon_slim synonym: "pars petrosa (os temporale)" EXACT [FMA:52871] synonym: "pars petrosa ossis temporalis" EXACT [] synonym: "petromastoid part of temporal bone" EXACT [FMA:52871] synonym: "petrosal" BROAD [VHOG:0001553] synonym: "petrosal bone" RELATED [FMA:52871] synonym: "petrous bone" RELATED [FMA:52871] synonym: "temporal bone petrous part" EXACT [] xref: EHDAA2:0001452 xref: EMAPA:17683 xref: FMA:52871 xref: GAID:234 xref: MA:0001477 xref: MESH:D010579 xref: NCIT:C32316 xref: SCTID:361733004 xref: UMLS:C1261761 {source="ncithesaurus:Ciliary_Process"} xref: VHOG:0001553 xref: Wikipedia:Petrous_part_of_the_temporal_bone is_a: UBERON:0005913 ! zone of bone organ relationship: BFO:0000050 UBERON:0001678 ! part of temporal bone relationship: BFO:0000050 UBERON:0002517 {source="FMA"} ! part of basicranium property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/9/96/Gray137.png" xsd:anyURI property_value: skos:prefLabel "petrous part of temporal bone" xsd:string [Term] id: UBERON:0001697 name: orbit of skull def: "Subdivision of skeleton that is an anterolateral part of the cranium and structurally supports the eye. Includes bones formed and located in sclerotic layer of eyeball." [http://orcid.org/0000-0002-6601-2165, TAO:0001410, Wikipedia:Orbit_(anatomy)] subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "bony orbit" EXACT [] synonym: "eye socket" EXACT [] synonym: "orbit" RELATED [ZFA:0001410] synonym: "orbit of skull" EXACT [FMA:53074] xref: BTO:0004687 xref: FMA:53074 xref: GAID:223 xref: galen:Orbit xref: MA:0002482 xref: MESH:D009915 xref: NCIT:C12347 xref: TAO:0001410 xref: UMLS:C0029180 {source="ncithesaurus:Orbit"} xref: Wikipedia:Orbit_(anatomy) xref: XAO:0003171 xref: ZFA:0001410 is_a: UBERON:0010912 ! subdivision of skeleton is_a: UBERON:0015212 ! lateral structure relationship: BFO:0000050 UBERON:0004088 ! part of orbital region relationship: BSPO:0000126 UBERON:0011156 {source="FMA-abduced-lr"} ! facial skeleton relationship: RO:0001015 UBERON:0000019 ! location of camera-type eye property_value: skos:prefLabel "orbit of skull" xsd:string [Term] id: UBERON:0001700 name: geniculate ganglion def: "The group of sensory neuron cell bodies associated with the facial nerve (seventh cranial nerve)." [ISBN:0-683-40008-8, MP:0001082] subset: efo_slim subset: human_reference_atlas subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "facial ganglion" RELATED [ZFA:0001291] synonym: "facial VII ganglion" EXACT [MA:0001076] synonym: "ganglion genicularum" EXACT [FMA:53414] synonym: "ganglion geniculi" RELATED [Wikipedia:Geniculate_ganglion] synonym: "ganglion geniculi nervi facialis" RELATED OMO:0003011 [Wikipedia:Geniculate_ganglion] synonym: "genicular ganglion" EXACT [FMA:53414, Wikipedia:Geniculate_ganglion] synonym: "geniculate" BROAD [Wikipedia:Geniculate_ganglion] synonym: "geniculate ganglion" RELATED [MA:0001076] synonym: "gVII" EXACT [ZFA:0001291] synonym: "internal genu" RELATED [Wikipedia:Geniculate_ganglion] xref: BAMS:GgVII xref: EFO:0003669 xref: EHDAA2:0000491 xref: EHDAA2:0004623 xref: EHDAA:5567 xref: EHDAA:6644 xref: EMAPA:17569 xref: FMA:53414 xref: GAID:718 xref: MA:0001076 xref: MESH:D005830 xref: NCIT:C12721 xref: neuronames:1535 xref: SCTID:279076005 xref: TAO:0001291 xref: UMLS:C0017406 {source="ncithesaurus:Geniculate_Ganglion"} xref: VHOG:0000707 xref: Wikipedia:Geniculate_ganglion xref: ZFA:0001291 is_a: UBERON:0001800 {source="ncithesaurus"} ! sensory ganglion is_a: UBERON:0009127 ! epibranchial ganglion is_a: UBERON:0010313 ! neural crest-derived structure intersection_of: UBERON:0001714 ! cranial ganglion intersection_of: extends_fibers_into UBERON:0001647 ! facial nerve relationship: extends_fibers_into UBERON:0001647 ! facial nerve relationship: RO:0002202 UBERON:0009124 {source="EHDAA2:0004623", source="ZFA"} ! develops from geniculate placode relationship: RO:0002202 UBERON:0010258 {source="EHDAA2:0004623"} ! develops from mesenchyme from rhombencephalic neural crest relationship: RO:0002202 UBERON:0012175 {source="EHDAA2:0000491"} ! develops from acoustico-facial VII-VIII ganglion complex property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/7/7d/Gray789.png" xsd:anyURI property_value: IAO:0000116 "resolve facial VII vs geniculate (see EHDAA2)" xsd:string property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "geniculate ganglion" xsd:string [Term] id: UBERON:0001701 name: glossopharyngeal ganglion def: "The group of neuron cell bodies associated with the ninth cranial nerve." [MP:0001096] subset: human_reference_atlas subset: pheno_slim subset: vertebrate_core synonym: "ganglion of glossopharyngeal nerve" EXACT [] synonym: "ganglion of glosspharyngeal nerve" EXACT [FMA:53471] synonym: "gIX" RELATED [] synonym: "glossopharyngeal IX ganglion" EXACT [MA:0001077] synonym: "petrosal ganglion" NARROW [ZFA:0001301] xref: EHDAA2:0000710 xref: EHDAA:2838 xref: EMAPA:16795 xref: FMA:53471 xref: MA:0001077 xref: SCTID:244451008 xref: TAO:0001301 xref: VHOG:0000702 xref: ZFA:0001301 is_a: UBERON:0009127 {source="ZFA"} ! epibranchial ganglion intersection_of: UBERON:0001714 ! cranial ganglion intersection_of: extends_fibers_into UBERON:0001649 ! glossopharyngeal nerve relationship: extends_fibers_into UBERON:0001649 ! glossopharyngeal nerve relationship: RO:0002254 UBERON:0005491 ! has developmental contribution from glossopharyngeal neural crest relationship: RO:0002254 UBERON:0009125 ! has developmental contribution from petrosal placode property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "glossopharyngeal ganglion" xsd:string [Term] id: UBERON:0001703 name: neurocranium def: "Subdivision of skeletal system that surrounds and protects the brain. Includes the skull base, sensory capsules and the central part of the skull roof." [PMID:11523816, TAO:MAH, Wikipedia:Neuroranium, ZFA:0001580] subset: human_reference_atlas subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "brain box" EXACT [] synonym: "brain case" RELATED [ZFA:0001580] synonym: "brain pan" RELATED [http://www.thefreedictionary.com/braincase] synonym: "braincase" RELATED [ZFA:0001580] xref: FMA:53672 xref: MA:0000317 xref: SCTID:361731002 xref: TAO:0001580 xref: Wikipedia:Neuroranium xref: XAO:0003170 xref: ZFA:0001580 is_a: BFO:0000002 is_a: UBERON:0011158 {source="FMA"} ! primary subdivision of skull relationship: BFO:0000050 UBERON:0003128 ! part of cranium relationship: protects UBERON:0000955 ! brain relationship: RO:0001015 UBERON:0000955 ! location of brain relationship: RO:0002202 UBERON:0004761 ! develops from cartilaginous neurocranium property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "neurocranium" xsd:string [Term] id: UBERON:0001705 name: nail def: "A horn-like keratin structure covering the dorsal aspect of the terminal phalanges of fingers and toes[WP]." [https://github.com/obophenotype/uberon/issues/120, Wikipedia:Nail_(anatomy)] comment: The nails of humans and the claws are moth are highly similar. Both species have a proximal nail fold, cuticle, nail matrix, nail bed, nail plate, and hyponychium. Distinguishing features are the shape of the nail and the presence of an extended hyponychium in the mouse [PMC3579226] subset: efo_slim subset: pheno_slim subset: uberon_slim synonym: "claw" NARROW SENSU [Wikipedia:Claw] synonym: "nail/claw" EXACT [http://orcid.org/0000-0002-6601-2165] synonym: "talon" RELATED [] xref: BTO:0001719 xref: CALOHA:TS-2034 xref: EFO:0000956 xref: EMAPA:35580 xref: EV:0100159 xref: FMA:54326 xref: GAID:1320 xref: galen:Nail xref: MA:0002703 xref: MAT:0000158 xref: MESH:D009262 xref: MIAA:0000158 xref: NCIT:C33156 xref: SCTID:72651009 xref: UMLS:C0027342 {source="ncithesaurus:Nail"} xref: VHOG:0001361 xref: Wikipedia:Nail_(anatomy) is_a: UBERON:0009564 ! distal limb integumentary appendage relationship: RO:0002473 GO:0045095 ! composed primarily of keratin filament property_value: terms:contributor https://orcid.org/0000-0001-9114-8737 property_value: terms:contributor https://orcid.org/0000-0002-6601-2165 [Term] id: UBERON:0001707 name: nasal cavity def: "An anatomical cavity that is part of the olfactory apparatus. This includes the space bounded anteriorly by the nares and posteriorly by the choanae, when these structures are present." [http://orcid.org/0000-0002-6601-2165] subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "cavitas nasalis" RELATED [BTO:0002096] synonym: "cavitas nasi" RELATED OMO:0003011 [BTO:0002096, Wikipedia:Nasal_cavity] synonym: "cavity of nose" EXACT [] synonym: "cavity of olfactory apparatus" EXACT [http://orcid.org/0000-0002-6601-2165] synonym: "cavum nasi" RELATED OMO:0003011 [Wikipedia:Nasal_cavity] synonym: "nasal canal" EXACT [ZFA:0000130] synonym: "nasal conduit space" EXACT [http://orcid.org/0000-0002-6601-2165] synonym: "nasal fossa" EXACT [Wikipedia:Nasal_cavity] synonym: "nasal pit" RELATED [] synonym: "olfactory cavity" RELATED [] synonym: "olfactory chamber" RELATED [http://orcid.org/0000-0002-6601-2165] synonym: "olfactory chamber cavity" EXACT [http://orcid.org/0000-0002-6601-2165] synonym: "olfactory pit" RELATED INCONSISTENT [ZFA:0000130] xref: AAO:0000314 xref: BTO:0002096 xref: EHDAA2:0001226 xref: EHDAA:6801 xref: EMAPA:17604 xref: FMA:54378 xref: GAID:350 xref: MA:0000284 xref: MESH:D009296 xref: NCIT:C12424 xref: SCTID:263481003 xref: TAO:0000130 xref: UMLS:C0027423 {source="ncithesaurus:Nasal_Cavity"} xref: VHOG:0000271 xref: Wikipedia:Nasal_cavity xref: ZFA:0000130 is_a: BFO:0000002 is_a: UBERON:0002553 ! anatomical cavity relationship: BFO:0000050 UBERON:0015788 {source="cjm"} ! part of olfactory apparatus chamber relationship: RO:0002202 UBERON:0005870 ! develops from olfactory pit property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/d/d4/Illu01_head_neck.jpg" xsd:anyURI property_value: IAO:0000116 "define the boundaries of this cavity for a variety of species and check that parthood relations are not too strong." xsd:string [Term] id: UBERON:0001708 name: jaw skeleton def: "Subdivision of skeleton which includes upper and lower jaw skeletons." [https://orcid.org/0000-0002-6601-2165, Wikipedia:Jaw] subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "anterior splanchnocranium" RELATED [] synonym: "jaw" EXACT [MA:0001905] synonym: "jaw cartilage" EXACT [ZFA:0001227] synonym: "jaws" RELATED [] synonym: "mandibular arch" RELATED [TAO:0001227] synonym: "mandibular arch skeleton" EXACT [ZFA:0001227] synonym: "oral jaw skeleton" RELATED [] synonym: "pharyngeal arch 1 skeleton" RELATED [] synonym: "visceral arch 1" RELATED [] xref: AAO:0000988 xref: BTO:0001749 xref: EMAPA:35455 xref: FMA:54396 xref: GAID:214 xref: galen:Jaw xref: MA:0001905 xref: MESH:D007568 xref: NCIT:C48821 xref: SCTID:181811001 xref: TAO:0001227 xref: UMLS:C0022359 {source="ncithesaurus:Jaw"} xref: Wikipedia:Jaw xref: ZFA:0001227 is_a: UBERON:0010314 ! structure with developmental contribution from neural crest is_a: UBERON:0010912 ! subdivision of skeleton intersection_of: UBERON:0010912 ! subdivision of skeleton intersection_of: RO:0002576 UBERON:0011595 ! skeleton of jaw region relationship: BFO:0000050 UBERON:0011156 {source="cjm"} ! part of facial skeleton relationship: RO:0002131 UBERON:0008895 ! overlaps splanchnocranium relationship: RO:0002576 UBERON:0011595 ! skeleton of jaw region property_value: IAO:0000116 "TODO - move ZFA:0001227 (it is the entire jaw skeleton)." xsd:string property_value: skos:prefLabel "jaw skeleton" xsd:string [Term] id: UBERON:0001709 name: upper jaw region def: "Subdivision of head that consists of the upper jaw skeletal elements plus associated soft tissue (skin, lips, muscle)[cjm]." [http://orcid.org/0000-0002-6601-2165, Wikipedia:Upper_jaw] comment: See notes for jaw w.r.t skeletal element vs subdivision of head. subset: uberon_slim subset: vertebrate_core synonym: "alveolodental arch of bimaxilla" RELATED [FMA:59399] synonym: "dorsal mandibular arch" RELATED [] synonym: "dorsal pharyngeal arch 1" RELATED INCONSISTENT [] synonym: "maxillary part of mouth" EXACT [FMA:59399] synonym: "maxillary part of mouth proper" RELATED [FMA:59399] synonym: "palatoquadrate arch" RELATED INCONSISTENT [] synonym: "upper pharyngeal jaws" RELATED [] xref: AAO:0000620 xref: EHDAA2:0002118 xref: EHDAA2:0004607 xref: EHDAA:8025 xref: EMAPA:17924 xref: FMA:59399 xref: ncithesaurus:Upper_Jaw xref: SCTID:362636001 xref: VHOG:0000454 xref: Wikipedia:Upper_jaw is_a: UBERON:0000475 ! organism subdivision intersection_of: UBERON:0000475 ! organism subdivision intersection_of: RO:0002551 UBERON:0003277 ! has skeleton skeleton of upper jaw disjoint_from: UBERON:0001710 ! lower jaw region relationship: BFO:0000050 UBERON:0004089 ! part of midface relationship: BFO:0000050 UBERON:0011595 ! part of jaw region relationship: RO:0002551 UBERON:0003277 ! has skeleton skeleton of upper jaw property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/a/a7/Gray189.png" xsd:anyURI property_value: skos:prefLabel "upper jaw region" xsd:string [Term] id: UBERON:0001710 name: lower jaw region def: "Subdivision of head that consists of the lower jaw skeletal elements plus associated soft tissue (skin, lips, muscle)[cjm]." [Wikipedia:Lower_jaw] comment: See notes for jaw w.r.t skeletal element vs subdivision of head subset: efo_slim subset: uberon_slim subset: vertebrate_core synonym: "lower part of mouth" RELATED [] synonym: "mandibular part of mouth" EXACT [FMA:59398] synonym: "mandibular series" RELATED [] xref: AAO:0000272 xref: EFO:0003660 xref: EHDAA2:0001018 xref: EHDAA:7995 xref: EMAPA:17906 xref: FMA:59398 xref: MESH:D008334 xref: ncithesaurus:Lower_Jaw xref: SCTID:362637005 xref: VHOG:0000453 xref: Wikipedia:Lower_jaw is_a: BFO:0000002 is_a: UBERON:0000475 ! organism subdivision intersection_of: UBERON:0000475 ! organism subdivision intersection_of: RO:0002551 UBERON:0003278 ! has skeleton skeleton of lower jaw relationship: BFO:0000050 UBERON:0011595 ! part of jaw region relationship: RO:0002202 UBERON:0005867 {source="Wikipedia:Mandibular_prominence"} ! develops from mandibular prominence relationship: RO:0002551 UBERON:0003278 ! has skeleton skeleton of lower jaw property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/6/64/Gray176.png" xsd:anyURI property_value: skos:prefLabel "lower jaw region" xsd:string [Term] id: UBERON:0001711 name: eyelid def: "A fold of skin that covers and protects part of the eyeball. Examples: upper eyelid, lower eyelid, nictitating membrane." [http://orcid.org/0000-0002-6601-2165] subset: pheno_slim subset: uberon_slim synonym: "blephara" RELATED OMO:0003004 [] synonym: "blepharon" EXACT [] synonym: "eye lid" EXACT [] synonym: "palpebra" EXACT [] synonym: "palpebrae" RELATED OMO:0003004 [] xref: BTO:0002241 xref: EHDAA2:0000487 xref: EHDAA:9037 xref: EMAPA:17829 xref: EV:0100338 xref: FMA:54437 xref: GAID:72 xref: MA:0000268 xref: MESH:D005143 xref: NCIT:C12713 xref: SCTID:265782007 xref: UMLS:C0015426 {source="ncithesaurus:Eyelid"} xref: VHOG:0000016 xref: Wikipedia:Eyelid is_a: UBERON:0000064 ! organ part relationship: BFO:0000050 UBERON:0000019 {source="multiple"} ! part of camera-type eye relationship: protects UBERON:0010409 ! ocular surface region relationship: RO:0002215 GO:0060082 ! capable of eye blink reflex relationship: RO:0002433 UBERON:0000019 ! contributes to morphology of camera-type eye property_value: foaf:depiction "https://upload.wikimedia.org/wikipedia/commons/8/84/Eye_makeup.jpg" xsd:anyURI [Term] id: UBERON:0001714 name: cranial ganglion def: "The groups of nerve cell bodies associated with the twelve cranial nerves." [ISBN:0-683-40008-8, MGI:csmith, MP:0001081, PMID:9362461] subset: efo_slim subset: human_reference_atlas subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "cranial ganglia" RELATED [] synonym: "cranial ganglion" EXACT [] synonym: "cranial ganglion part of peripheral nervous system" EXACT [BIRNLEX:2597] synonym: "cranial ganglion/nerve" EXACT [] synonym: "cranial nerve ganglion" EXACT [] synonym: "cranial neural ganglion" EXACT [] synonym: "cranial neural tree organ ganglion" EXACT [OBOL:automatic] synonym: "ganglion of cranial nerve" EXACT [FMA:54502] synonym: "ganglion of cranial neural tree organ" EXACT [OBOL:automatic] synonym: "head ganglion" RELATED [] synonym: "presumptive cranial ganglia" RELATED [ZFA:0000013] xref: BIRNLEX:2597 xref: BTO:0000106 xref: EFO:0000902 xref: EMAPA:16659 xref: FMA:54502 xref: MA:0000213 xref: MA:0000214 xref: MAT:0000200 xref: MIAA:0000200 xref: SCTID:244448001 xref: TAO:0000013 xref: VHOG:0000076 xref: Wikipedia:Cranial_nerve_ganglion xref: XAO:0000027 xref: ZFA:0000013 is_a: UBERON:0000045 ! ganglion intersection_of: UBERON:0000045 ! ganglion intersection_of: extends_fibers_into UBERON:0034713 ! cranial neuron projection bundle relationship: BFO:0000050 UBERON:0000033 ! part of head relationship: extends_fibers_into UBERON:0034713 ! cranial neuron projection bundle property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "cranial ganglion" xsd:string [Term] id: UBERON:0001715 name: oculomotor nuclear complex def: "Nuclear complex containing subnuclei that give rise to the axons of the occulomotor nerve, both motor and parasympathetic fibers, situated at the midline at the level of the superior colliculus in the midbrain tegmentum (Brodal, Neurological Anatomy, 3rd ed., 1981, pg 533-534)." [BIRNLEX:1240] subset: efo_slim subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "motor nucleus III" RELATED [] synonym: "nIII" RELATED [] synonym: "nucleus nervi oculomotorii" EXACT OMO:0003011 [FMA:54510, FMA:TA] synonym: "nucleus oculomotorius" RELATED OMO:0003011 [NeuroNames:492] synonym: "nucleus of oculomotor nerve" EXACT [FMA:54510] synonym: "nucleus of oculomotor nuclear complex" EXACT [http://orcid.org/0000-0002-6601-2165] synonym: "nucleus of third cranial nerve" EXACT [FMA:54510] synonym: "oculomotor III nuclear complex" EXACT [] synonym: "oculomotor III nucleus" EXACT [MA:0001073] synonym: "oculomotor motornucleus" RELATED [XAO:0004389] synonym: "oculomotor nucleus" EXACT [FMA:54510] synonym: "OM" EXACT OMO:0003000 [XAO:0004389] synonym: "third cranial nerve nucleus" EXACT [FMA:54510] xref: BAMS:3 xref: BAMS:III xref: BIRNLEX:1240 xref: BM:MB-III xref: DHBA:12198 xref: EFO:0002468 xref: EHDAA2:0004211 xref: EMAPA:35605 xref: EV:0100250 xref: FMA:54510 xref: HBA:9030 xref: MA:0001073 xref: MBA:35 xref: NCIT:C12897 xref: neuronames:492 {source="BIRNLEX:1240"} xref: SCTID:362457000 xref: TAO:0000553 xref: UMLS:C0228686 {source="ncithesaurus:Oculomotor_Nucleus", source="BIRNLEX:1240"} xref: VHOG:0001389 xref: Wikipedia:Nucleus_of_oculomotor_nerve xref: XAO:0004389 xref: ZFA:0000553 is_a: UBERON:0007245 {source="FMA"} ! nuclear complex of neuraxis is_a: UBERON:0019267 ! gray matter of midbrain relationship: BFO:0000050 UBERON:0001943 {source="ZFA"} ! part of midbrain tegmentum property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/d/da/Cn3nucleus.png" xsd:anyURI property_value: skos:prefLabel "oculomotor nuclear complex" xsd:string [Term] id: UBERON:0001720 name: cochlear nucleus def: "Any of the nuclei of the cochlear nuclear complex." [http://orcid.org/0000-0002-6601-2165] subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "cochlear nucleus of acoustic nerve" EXACT [] synonym: "cochlear nucleus of eighth cranial nerve" EXACT [] synonym: "cochlear VIII nucleus" EXACT [MA:0001012] synonym: "nucleus of cochlear nerve" EXACT [] synonym: "statoacoustic (VIII) nucleus" EXACT [] synonym: "vestibulocochlear nucleus" RELATED [] xref: EMAPA:35248 xref: FMA:54603 xref: GAID:601 xref: MA:0001012 xref: MESH:D017626 xref: NCIT:C12837 xref: SCTID:362463009 xref: TAO:0002243 xref: Wikipedia:Cochlear_nucleus xref: ZFA:0001638 is_a: UBERON:0007635 ! nucleus of medulla oblongata intersection_of: UBERON:0000125 ! neural nucleus intersection_of: BFO:0000050 UBERON:0002610 ! part of cochlear nuclear complex relationship: BFO:0000050 UBERON:0002610 ! part of cochlear nuclear complex relationship: extends_fibers_into UBERON:0004727 ! cochlear nerve relationship: RO:0002433 UBERON:0002298 ! contributes to morphology of brainstem property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/5/52/Gray691.png" xsd:anyURI property_value: skos:prefLabel "cochlear nucleus" xsd:string [Term] id: UBERON:0001723 name: tongue def: "A muscular organ in the floor of the mouth." [FEED:rd, https://github.com/obophenotype/uberon/issues/256] subset: efo_slim subset: human_reference_atlas subset: organ_slim subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "glossus" RELATED [Wikipedia:Tongue] xref: AAO:0010360 xref: BTO:0001385 xref: CALOHA:TS-1050 xref: EFO:0000833 xref: EHDAA2:0002062 xref: EHDAA:9144 xref: EMAPA:17185 xref: EV:0100058 xref: FMA:54640 xref: GAID:816 xref: MA:0000347 xref: MAT:0000040 xref: MESH:D014059 xref: MIAA:0000040 xref: NCIT:C12422 xref: SCTID:181226008 xref: TAO:0005333 xref: UMLS:C0040408 {source="ncithesaurus:Tongue"} xref: VHOG:0000419 xref: Wikipedia:Tongue xref: XAO:0000446 xref: ZFA:0005333 is_a: BFO:0000002 is_a: UBERON:0000020 {source="GO"} ! sense organ is_a: UBERON:0013765 ! digestive system element relationship: BFO:0000050 UBERON:0000165 {source="BTO", source="EHDAA2", source="FMA", source="ZFA"} ! part of mouth relationship: BFO:0000050 UBERON:0001033 {source="MA"} ! part of gustatory system relationship: RO:0002202 UBERON:0008814 ! develops from pharyngeal arch system relationship: RO:0002220 UBERON:0000166 ! adjacent to oral opening relationship: RO:0002254 UBERON:0006260 ! has developmental contribution from lingual swellings relationship: RO:0002254 UBERON:0006756 {source="Wikipedia"} ! has developmental contribution from median lingual swelling relationship: RO:0002254 UBERON:0006757 {source="Wikipedia"} ! has developmental contribution from lateral lingual swelling relationship: RO:0002433 UBERON:0001007 ! contributes to morphology of digestive system relationship: RO:0002495 UBERON:0010056 {evidence="definitional"} ! immediate transformation of future tongue property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/a/a6/Tongue.agr.jpg" xsd:anyURI property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/mouth-female/v1.0/assets/3d-vh-f-mouth.glb" xsd:anyURI property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/mouth-male/v1.0/assets/3d-vh-m-mouth.glb" xsd:anyURI property_value: IAO:0000116 "in MA the tongue is part of the oral region, which in uberon is treated as the oral opening. consider revising oral opening - oral region equivalence." xsd:string property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "tongue" xsd:string [Term] id: UBERON:0001725 name: cranial synchondrosis def: "The cartilaginous joints of the skull; these include sphenoethmoidal synchondrosis, sphenooccipital synchondrosis, sphenopetrosal synchondrosis, petrooccipital synchondrosis, anterior intraoccipital synchondrosis and posterior intraoccipital synchondrosis." [http://www.medilexicon.com/medicaldictionary.php?t=87514] xref: EMAPA:35264 xref: FMA:54816 xref: MA:0001502 xref: SCTID:314228003 is_a: UBERON:0002215 {source="FMA"} ! synchondrosis intersection_of: UBERON:0002215 ! synchondrosis intersection_of: BFO:0000050 UBERON:0003129 ! part of skull relationship: BFO:0000050 UBERON:0003129 ! part of skull property_value: skos:prefLabel "cranial synchondrosis" xsd:string [Term] id: UBERON:0001726 name: papilla of tongue subset: pheno_slim synonym: "lingual papilla" EXACT [] synonym: "tongue papilla" EXACT [] xref: BIRNLEX:4102 xref: EMAPA:32777 xref: FMA:54819 xref: MA:0001593 xref: NCIT:C33258 xref: SCTID:368728006 xref: UMLS:C0226964 {source="ncithesaurus:Papilla_of_the_Tongue", source="BIRNLEX:4102"} xref: UMLS:C1289183 {source="BIRNLEX:4102"} is_a: UBERON:0000064 ! organ part relationship: BFO:0000050 UBERON:0005020 ! part of mucosa of tongue relationship: BFO:0000050 UBERON:0009471 {source="FMA-modified"} ! part of dorsum of tongue property_value: skos:prefLabel "papilla of tongue" xsd:string [Term] id: UBERON:0001727 name: taste bud def: "A specialized receptor organ that is a collection of cells spanning the gustatory epithelium." [http://periowiki.wikispot.org/Taste_bud_histology] subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "caliculus gustatorius" RELATED OMO:0003004 [Wikipedia:Taste_bud] synonym: "taste buds" RELATED OMO:0003004 [Wikipedia:Taste_bud] synonym: "taste-bud" RELATED [Wikipedia:Taste_bud] synonym: "tastebud" EXACT [Wikipedia:Taste_bud] synonym: "tastebuds" RELATED OMO:0003004 [Wikipedia:Taste_bud] xref: AAO:0010573 xref: BIRNLEX:4101 xref: BTO:0000989 xref: CALOHA:TS-1015 xref: EMAPA:35850 xref: FMA:54825 xref: GAID:815 xref: http://uri.neuinfo.org/nif/nifstd/nifext_14 xref: MA:0001591 xref: MESH:D013650 xref: NCIT:C96518 xref: SCTID:362099006 xref: TAO:0001074 xref: UMLS:C0039337 {source="ncithesaurus:Taste_Bud", source="BIRNLEX:4101"} xref: VHOG:0000130 xref: Wikipedia:Taste_bud xref: XAO:0000445 xref: ZFA:0001074 is_a: UBERON:0003212 ! gustatory organ is_a: UBERON:0004119 ! endoderm-derived structure relationship: BFO:0000050 UBERON:0002926 {source="NIF"} ! part of gustatory epithelium relationship: BFO:0000051 CL:0000209 {source="FMA"} ! has part taste receptor cell relationship: RO:0002202 UBERON:0007690 {source="http://dev.biologists.org/content/128/22/4573.full"} ! develops from early pharyngeal endoderm relationship: RO:0002215 GO:0050912 ! capable of detection of chemical stimulus involved in sensory perception of taste relationship: RO:0002433 UBERON:0001033 ! contributes to morphology of gustatory system property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/5/5a/Gray1018.png" xsd:anyURI property_value: skos:prefLabel "taste bud" xsd:string [Term] id: UBERON:0001728 name: nasopharynx def: "The section of the pharynx that lies above the soft palate." [MGI:cwg, MP:0002251] subset: human_reference_atlas subset: pheno_slim subset: uberon_slim synonym: "epipharynx" RELATED [Wikipedia:Pharynx] synonym: "nasal part of pharynx" EXACT [] synonym: "Nasenrachenraum" RELATED [BTO:0000662] synonym: "pars nasalis pharyngis" RELATED OMO:0003011 [Wikipedia:Nasopharynx] synonym: "rhinopharynx" EXACT [] xref: BTO:0000662 xref: CALOHA:TS-0663 xref: EHDAA2:0001239 xref: EHDAA:7086 xref: EMAPA:17670 xref: EV:0100066 xref: FMA:54878 xref: GAID:339 xref: MA:0000443 xref: MAT:0000447 xref: MESH:D009305 xref: NCIT:C12423 xref: SCTID:181200003 xref: UMLS:C0027442 {source="ncithesaurus:Nasopharynx"} xref: VHOG:0000375 xref: Wikipedia:Nasopharynx is_a: UBERON:0000072 ! proximo-distal subdivision of respiratory tract relationship: BFO:0000050 UBERON:0001042 ! part of chordate pharynx relationship: BFO:0000050 UBERON:0001557 ! part of upper respiratory tract relationship: RO:0002433 UBERON:0001042 ! contributes to morphology of chordate pharynx property_value: foaf:depiction "https://upload.wikimedia.org/wikipedia/commons/4/4a/Illu_pharynx.jpg" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001731 name: cavity of pharynx def: "An anatomical space that is enclosed by a pharynx." [OBOL:automatic] synonym: "cavitas pharyngealis" RELATED OMO:0003011 [] synonym: "cavitas pharyngis" RELATED [BTO:0002097] synonym: "lumen of pharynx" EXACT [] synonym: "pharyngeal cavity" EXACT [] xref: AAO:0010435 xref: BSA:0000113 xref: BTO:0002097 xref: EMAPA:18381 xref: FMA:54935 xref: SCTID:180543003 xref: XAO:0000105 is_a: BFO:0000002 is_a: UBERON:0000464 ! anatomical space intersection_of: UBERON:0000464 ! anatomical space intersection_of: RO:0002572 UBERON:0006562 ! luminal space of pharynx relationship: RO:0002202 UBERON:0001041 {source="XAO"} ! develops from foregut relationship: RO:0002572 UBERON:0006562 ! luminal space of pharynx property_value: skos:prefLabel "cavity of pharynx" xsd:string [Term] id: UBERON:0001735 name: tonsillar ring def: "The circular lymphoid tissue formed by the lingual, pharyngeal, and faucial tonsils." [MGI:cwg, MP:0002379] subset: pheno_slim subset: uberon_slim synonym: "anulus lymphoideus pharyngis" EXACT OMO:0003011 [FMA:55070, FMA:TA] synonym: "oropharyngeal lymphoid tissue" EXACT [] synonym: "pharyngeal lymphatic ring" EXACT [] synonym: "pharyngeal lymphoid ring" EXACT [] synonym: "Waldeyer's ring" EXACT [] synonym: "Waldeyer's tonsillar ring" EXACT [] xref: FMA:55070 xref: MA:0000752 xref: NCIT:C73468 xref: SCTID:56411004 xref: UMLS:C0459892 {source="ncithesaurus:Waldeyers_Tonsillar_Ring"} xref: Wikipedia:Waldeyer's_ring is_a: UBERON:0001962 ! gut-associated lymphoid tissue relationship: BFO:0000050 UBERON:0001042 ! part of chordate pharynx property_value: seeAlso FMA:79771 [Term] id: UBERON:0001736 name: submandibular gland def: "Either of the paired compound tubuloalveolar (aka tubuloacinar) major salivary glands composed of both serous and mucous secretory cells and situated beneath the mandible." [DOI:10.1111/j.1432-0436.2006.00088.x, MGI:anna] comment: lobular, sexually dimorphic in mouse subset: efo_slim subset: human_reference_atlas subset: pheno_slim subset: uberon_slim synonym: "glandula submandibularis" RELATED OMO:0003011 [Wikipedia:Submandibular_gland] synonym: "mandibular gland" EXACT SENSU [http://www.avdc.org/Nomenclature.pdf] synonym: "mandibular salivary gland" EXACT SENSU [http://www.avdc.org/Nomenclature.pdf] synonym: "maxillary gland" RELATED [] synonym: "submandibular salivary gland" EXACT [] synonym: "submaxillary gland" RELATED [] xref: BTO:0001316 xref: CALOHA:TS-0988 xref: EFO:0001387 xref: EMAPA:18812 xref: EV:0100061 xref: FMA:55093 xref: GAID:942 xref: MA:0001589 xref: MESH:D013363 xref: NCIT:C12233 xref: SCTID:181235001 xref: UMLS:C0038556 {source="ncithesaurus:Submandibular_Gland"} xref: VHOG:0000364 xref: Wikipedia:Submandibular_gland is_a: BFO:0000002 is_a: UBERON:0001829 ! major salivary gland relationship: BSPO:0000126 UBERON:0001710 {source="FMA-abduced-lr"} ! lower jaw region relationship: RO:0002202 UBERON:0006298 ! develops from submandibular gland primordium property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/5/51/Illu_quiz_hn_02.jpg" xsd:anyURI property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/mouth-female/v1.0/assets/3d-vh-f-mouth.glb" xsd:anyURI property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/mouth-male/v1.0/assets/3d-vh-m-mouth.glb" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001737 name: larynx def: "A continuation of the pharynx that is involved in breathing, sound production, and protecting the trachea against food aspiration." [http://orcid.org/0000-0002-6601-2165, Wikipedia:Larynx] subset: efo_slim subset: pheno_slim subset: uberon_slim xref: AAO:0000268 xref: BTO:0001208 xref: CALOHA:TS-0532 xref: EFO:0000838 xref: EHDAA2:0004063 xref: EMAPA:18333 xref: EV:0100039 xref: FMA:55097 xref: GAID:108 xref: galen:Larynx xref: MA:0000414 xref: MAT:0000187 xref: MESH:D007830 xref: MIAA:0000187 xref: NCIT:C12420 xref: SCTID:181212004 xref: UMLS:C0023078 {source="ncithesaurus:Larynx"} xref: VHOG:0001279 xref: Wikipedia:Larynx xref: XAO:0003081 is_a: BFO:0000002 is_a: UBERON:0000072 ! proximo-distal subdivision of respiratory tract relationship: RO:0002005 UBERON:0003716 ! innervated by recurrent laryngeal nerve relationship: RO:0002202 UBERON:0008947 {source="EHDAA2"} ! develops from respiratory primordium relationship: RO:0002433 UBERON:0001004 ! contributes to morphology of respiratory system property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/8/8a/Larynx_external_en.svg" xsd:anyURI property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/larynx-female/v1.1/assets/3d-vh-f-larynx.glb" xsd:anyURI property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/larynx-male/v1.1/assets/3d-vh-m-larynx.glb" xsd:anyURI property_value: skos:prefLabel "larynx" xsd:string [Term] id: UBERON:0001739 name: laryngeal cartilage def: "The cartilaginous structures that support the larynx." [MP:0002256] subset: pheno_slim synonym: "cartilage of larynx" EXACT [FMA:55108] synonym: "cartilagines laryngeales" EXACT OMO:0003004 [] synonym: "larynx cartilage" EXACT [VHOG:0001550] xref: BTO:0003660 xref: EHDAA:8157 xref: EMAPA:18697 xref: FMA:55108 xref: GAID:107 xref: MA:0001758 xref: MESH:D007817 xref: NCIT:C12281 xref: SCTID:263482005 xref: UMLS:C0023050 {source="ncithesaurus:Laryngeal_Cartilage"} xref: VHOG:0001550 is_a: UBERON:0003406 ! cartilage of respiratory system is_a: UBERON:0011004 ! pharyngeal arch cartilage intersection_of: UBERON:0007844 ! cartilage element intersection_of: BFO:0000050 UBERON:0001737 ! part of larynx relationship: BFO:0000050 UBERON:0010212 ! part of laryngeal apparatus relationship: RO:0002202 UBERON:0010213 ! develops from laryngeal pre-cartilage condensation property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/larynx-female/v1.1/assets/3d-vh-f-larynx.glb" xsd:anyURI property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/larynx-male/v1.1/assets/3d-vh-m-larynx.glb" xsd:anyURI property_value: skos:prefLabel "laryngeal cartilage" xsd:string [Term] id: UBERON:0001743 name: ligament of larynx def: "A ligament that is part of a larynx and connexts the cartilages of the larynx." [http://education.yahoo.com/reference/gray/subjects/subject/236] synonym: "laryngeal ligament" EXACT [] synonym: "larynx ligament" EXACT [MA:0001755] xref: EMAPA:37626 {source="MA:th"} xref: FMA:55131 xref: MA:0001755 xref: NCIT:C32933 xref: SCTID:279508004 xref: UMLS:C0458519 {source="ncithesaurus:Laryngeal_Ligament"} is_a: UBERON:0008845 {source="FMA"} ! nonskeletal ligament intersection_of: UBERON:0000211 ! ligament intersection_of: BFO:0000050 UBERON:0001737 ! part of larynx relationship: BFO:0000050 UBERON:0001737 ! part of larynx [Term] id: UBERON:0001744 name: lymphoid tissue def: "Portion of connective tissue with various types of white blood cells enmeshed in it, most numerous being the lymphocytes[WP]." [Wikipedia:Lymphoid_tissue] subset: pheno_slim subset: uberon_slim synonym: "lymphatic tissue" EXACT [] synonym: "lymphocytic tissue" EXACT [] xref: BTO:0000753 xref: CALOHA:TS-0584 xref: FMA:55220 xref: GAID:342 xref: galen:LymphoidTissue xref: MA:0002436 xref: MESH:D008221 xref: NCIT:C13049 xref: SCTID:181768009 xref: UMLS:C0024296 {source="ncithesaurus:Lymphoid_Tissue"} xref: Wikipedia:Lymphoid_tissue is_a: BFO:0000002 is_a: UBERON:0034769 {source="FMA"} ! lymphomyeloid tissue relationship: BFO:0000050 UBERON:0002465 ! part of lymphoid system relationship: BFO:0000051 CL:0000542 ! has part lymphocyte [Term] id: UBERON:0001745 name: secondary nodular lymphoid tissue def: "A lymphoid follicle that contains a germinal center." [CL:tm] subset: uberon_slim synonym: "peripheral lymphoid tissue" EXACT [] synonym: "secondary lymphoid nodule" EXACT [] synonym: "secondary lymphoid tissue" EXACT [] xref: FMA:55224 xref: GAID:946 is_a: UBERON:0000444 ! lymphoid follicle intersection_of: UBERON:0000444 ! lymphoid follicle intersection_of: BFO:0000051 UBERON:0010754 ! has part germinal center relationship: BFO:0000051 UBERON:0010754 ! has part germinal center relationship: BFO:0000067 GO:0042100 ! contains process B cell proliferation relationship: RO:0002202 UBERON:0010422 ! develops from primary nodular lymphoid tissue property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/2/2f/Keimzentrum.jpg" xsd:anyURI [Term] id: UBERON:0001746 name: capsule of thyroid gland synonym: "capsula fibrosa glandulae thyroideae" EXACT OMO:0003011 [FMA:55513, FMA:TA] synonym: "fibrous capsule of thyroid gland" EXACT [FMA:55513] synonym: "thyroid capsule" EXACT [] synonym: "thyroid gland capsule" EXACT [MA:0002675] xref: EMAPA:37767 {source="MA:th"} xref: FMA:55513 xref: MA:0002675 xref: NCIT:C33781 xref: SCTID:176859009 xref: UMLS:C0229575 {source="ncithesaurus:Thyroid_Gland_Capsule"} is_a: UBERON:0003893 ! capsule intersection_of: UBERON:0003893 ! capsule intersection_of: BFO:0000050 UBERON:0002046 ! part of thyroid gland relationship: BFO:0000050 UBERON:0002046 ! part of thyroid gland [Term] id: UBERON:0001747 name: parenchyma of thyroid gland def: "A parenchyma that is part of a thyroid follicle [Automatically generated definition]." [OBOL:automatic] synonym: "parenchyma glandulae thyroideae" RELATED [BTO:0004579] synonym: "parenchyma of thyroid" EXACT [OBOL:accepted] synonym: "parenchyma of thyroid follicle" EXACT [OBOL:automatic] synonym: "parenchyma of thyroid gland follicle" EXACT [OBOL:automatic] synonym: "thyroid follicle parenchyma" EXACT [OBOL:automatic] synonym: "thyroid gland follicle parenchyma" EXACT [OBOL:automatic] synonym: "thyroid gland parenchyma" EXACT [] synonym: "thyroid parenchyma" EXACT [OBOL:accepted] xref: BTO:0004579 xref: EMAPA:37769 {source="MA:th"} xref: FMA:55515 xref: MA:0000730 xref: SCTID:371402001 is_a: BFO:0000002 is_a: UBERON:0000353 ! parenchyma intersection_of: UBERON:0000353 ! parenchyma intersection_of: BFO:0000050 UBERON:0002046 ! part of thyroid gland relationship: BFO:0000050 UBERON:0002046 ! part of thyroid gland relationship: BFO:0000051 CL:0000570 {source="FMA"} ! has part parafollicular cell relationship: BFO:0000051 CL:0002258 {source="FMA"} ! has part thyroid follicular cell [Term] id: UBERON:0001748 name: capsule of parathyroid gland def: "The dense and irregular connective tissue capsule surrounding a parathyroid gland." [MGI:anna] subset: pheno_slim synonym: "parathyroid gland capsule" EXACT [] xref: EMAPA:35663 xref: FMA:55566 xref: MA:0002676 xref: NCIT:C33265 xref: UMLS:C0927176 {source="ncithesaurus:Parathyroid_Gland_Capsule"} is_a: UBERON:0003893 ! capsule intersection_of: UBERON:0003893 ! capsule intersection_of: RO:0002007 UBERON:0001132 ! bounding layer of parathyroid gland relationship: RO:0002007 UBERON:0001132 ! bounding layer of parathyroid gland relationship: RO:0002473 UBERON:0011822 ! composed primarily of dense irregular connective tissue [Term] id: UBERON:0001749 name: parenchyma of parathyroid gland def: "A parenchyma that is part of a parathyroid gland [Automatically generated definition]." [OBOL:automatic] synonym: "parathyroid gland parenchyma" EXACT [] synonym: "parathyroid parenchyma" EXACT [OBOL:automatic] synonym: "parenchyma of parathyroid" EXACT [OBOL:automatic] xref: EMAPA:35664 xref: FMA:55569 xref: MA:0002677 is_a: BFO:0000002 is_a: UBERON:0000353 ! parenchyma intersection_of: UBERON:0000353 ! parenchyma intersection_of: BFO:0000050 UBERON:0001132 ! part of parathyroid gland relationship: BFO:0000050 UBERON:0001132 ! part of parathyroid gland relationship: BFO:0000051 CL:0000446 {source="FMA"} ! has part chief cell of parathyroid gland relationship: BFO:0000051 CL:0002199 {source="FMA"} ! has part oxyphil cell of parathyroid gland [Term] id: UBERON:0001750 name: lacrimal apparatus def: "A network of orbital structures of the eye that secrete and drain tears from the surface of the eyeball into the nasal cavity; these parts include the lacrimal glands, lacrimal lake, lacrimal ducts, lacrimal canals, lacrimal sacs, nasolacrimal ducts, and lacrimal puncta." [MGI:anna] subset: pheno_slim subset: uberon_slim synonym: "apparatus lacrimalis" EXACT OMO:0003011 [Wikipedia:Lacrimal_apparatus] synonym: "lacrimal drainage system" RELATED [https://orcid.org/0000-0002-6601-2165] synonym: "lacrymal system" EXACT [MGI:anna] synonym: "nasolacrimal drainage system" RELATED [https://orcid.org/0000-0002-6601-2165] synonym: "nasolacrimal system" RELATED [HPO:pr] xref: EMAPA:35462 xref: FMA:55605 xref: GAID:901 xref: MA:0000274 xref: MESH:D007765 xref: NCIT:C32905 xref: UMLS:C0022903 {source="ncithesaurus:Lacrimal_Apparatus"} xref: Wikipedia:Lacrimal_apparatus is_a: BFO:0000002 is_a: UBERON:0000467 ! anatomical system relationship: BFO:0000050 UBERON:0010409 {source="MA"} ! part of ocular surface region relationship: BFO:0000050 UBERON:0035639 {source="HPO:pr"} ! part of ocular adnexa relationship: RO:0002162 NCBITaxon:32523 ! in taxon Tetrapoda relationship: RO:0002202 UBERON:0000076 {source="ISBN:0781772214"} ! develops from external ectoderm relationship: RO:0002433 UBERON:0000019 ! contributes to morphology of camera-type eye property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/c/cf/Gray896.png" xsd:anyURI property_value: IAO:0000116 "TODO - resolve canaliculus vs tear duct vs lacrimal vs nasolacrimal" xsd:string [Term] id: UBERON:0001751 name: dentine def: "Collagen-rich odontogenic tissue characteristic of teeth and tooth-like skeletal elements (e.g., odontodes); mature dentine is mineralized and develops from predentine tissue; often (but not always) tubular and acellular." [GO_REF:0000034, http://dx.plos.org/10.1371/journal.pone.0051070, PSPUB:0000170, VSAO:0000069] comment: . subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "dentin" EXACT [MA:0002542, ZFA:0005143] synonym: "dentine of tooth" EXACT [] synonym: "predentin" NARROW [GO:0070468] xref: BTO:0003453 xref: EMAPA:35281 xref: FMA:55628 xref: GAID:1272 xref: MA:0002542 xref: MESH:D003804 xref: NCIT:C32453 xref: SCTID:362112004 xref: TAO:0005143 xref: UMLS:C0011429 {source="ncithesaurus:Dentin"} xref: VHOG:0001589 xref: VSAO:0000069 xref: Wikipedia:Dentin xref: XAO:0004051 xref: ZFA:0005143 is_a: UBERON:0010313 ! neural crest-derived structure is_a: UBERON:0010365 {source="VSAO"} ! odontoid tissue is_a: UBERON:4000013 ! mineralized skeletal tissue relationship: RO:0002494 UBERON:0011587 {source="VSAO"} ! transformation of pre-dentine [Term] id: UBERON:0001752 name: enamel def: "A dentine-like hypermineralized substance that covers the tooth tip. Enamel's primary mineral is hydroxylapatite, which is a crystalline calcium phosphate. Unlike dentin and bone, enamel does not contain collagen. Instead, it has two unique classes of proteins called amelogenins and enamelins[WP]." [Wikipedia:Enamel_organ, ZFIN:curator] subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "enamel of tooth" EXACT [] synonym: "enamel tissue" EXACT [VSAO:curator] synonym: "enameloid" RELATED [] synonym: "tooth enamel" EXACT [] xref: BTO:0001844 xref: CALOHA:TS-1057 xref: EMAPA:35303 xref: FMA:55629 xref: MA:0002543 xref: MESH:D003743 xref: NCIT:C32505 xref: SCTID:362113009 xref: UMLS:C0011350 {source="ncithesaurus:Enamel"} xref: VSAO:0000065 xref: Wikipedia:Enamel_organ xref: XAO:0004198 is_a: UBERON:0010365 {source="VSAO"} ! odontoid tissue is_a: UBERON:4000013 ! mineralized skeletal tissue relationship: RO:0002202 UBERON:0011588 {source="VSAO"} ! develops from pre-enamel relationship: RO:0002473 CHEBI:52255 ! composed primarily of property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/6/66/Enamelorgan11-17-05.jpg" xsd:anyURI property_value: IAO:0000116 "current classification under substance of tooth may be turned into taxon GCI (e.g. sharks have enamel in dermal denticles)" xsd:string property_value: RO:0002161 NCBITaxon:9359 {source="PMID:19730686"} property_value: RO:0002161 NCBITaxon:9816 {source="PMID:19730686"} [Term] id: UBERON:0001753 name: cementum def: "Odontoid tissue that is deposited by cementoblasts onto dentine tissue and functions to attach teeth, odontodes and other odontogenic derivatives to bone tissue and the integument." [GO_REF:0000034, http://dx.plos.org/10.1371/journal.pone.0051070, PSPUB:0000170, VSAO:0000062] subset: pheno_slim synonym: "bone of attachment" RELATED [VSAO:0000062] synonym: "cement" EXACT [FMA:55630] synonym: "cement of tooth" EXACT [] synonym: "cementum" EXACT [] synonym: "cementum of tooth" EXACT [] xref: BTO:0002525 xref: CALOHA:TS-2163 xref: EMAPA:35203 xref: FMA:55630 xref: MA:0002541 xref: MESH:D003739 xref: NCIT:C32276 xref: SCTID:362114003 xref: UMLS:C0011343 {source="ncithesaurus:Cementum"} xref: VSAO:0000062 xref: Wikipedia:Cementum xref: XAO:0004196 is_a: UBERON:0010365 {source="VSAO"} ! odontoid tissue relationship: RO:0002254 UBERON:0008969 {source="PMID:19767574", source="Wikipedia"} ! has developmental contribution from dental follicle property_value: foaf:depiction "https://upload.wikimedia.org/wikipedia/commons/d/dc/The_Periodontium.jpg" xsd:anyURI [Term] id: UBERON:0001754 name: dental pulp def: "The part in the center of a tooth made up of living soft tissue and cells called odontoblasts[WP]." [Wikipedia:Dental_pulp] subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "dental pulp cell" RELATED [BTO:0000339] synonym: "pulp of tooth" EXACT [] synonym: "tooth pulp" EXACT [ZFA:0005141] xref: BTO:0000339 xref: CALOHA:TS-0195 xref: EMAPA:35274 xref: FMA:55631 xref: GAID:1270 xref: MA:0001599 xref: MESH:D003782 xref: NCIT:C32451 xref: SCTID:362110007 xref: TAO:0005141 xref: UMLS:C0011399 {source="ncithesaurus:Dental_Pulp"} xref: VHOG:0001469 xref: Wikipedia:Dental_pulp xref: ZFA:0005141 is_a: BFO:0000002 is_a: UBERON:0011825 {source="FMA"} ! loose connective tissue relationship: BFO:0000050 UBERON:0001091 ! part of calcareous tooth relationship: BFO:0000051 CL:0000060 ! has part odontoblast relationship: RO:0002202 UBERON:0001763 {source="ZFA"} ! develops from odontogenic papilla property_value: foaf:depiction "https://upload.wikimedia.org/wikipedia/commons/2/2e/Tooth_Section.svg" xsd:anyURI [Term] id: UBERON:0001756 name: middle ear def: "The middle ear is the air-filled cavity within the skull of vertebrates that lies between the outer ear and the inner ear. It is linked to the pharynx (and therefore to outside air) via the Eustachian tube and in mammals contains the three ear ossicles, which transmit auditory vibrations from the outer ear (via the tympanum) to the inner ear (via the oval window)[GO]." [GO:0042474, Wikipedia:Middle_ear] subset: pheno_slim subset: uberon_slim synonym: "auris media" RELATED OMO:0003011 [BTO:0002099, Wikipedia:Middle_ear] xref: AAO:0011065 xref: BIRNLEX:1695 xref: BTO:0002099 xref: CALOHA:TS-2233 xref: EHDAA2:0001181 xref: EHDAA:5693 xref: EMAPA:17000 xref: EV:0100357 xref: FMA:56513 xref: GAID:165 xref: MA:0000253 xref: MAT:0000146 xref: MESH:D004432 xref: MIAA:0000146 xref: NCIT:C12274 xref: SCTID:181185000 xref: UMLS:C0013455 {source="ncithesaurus:Middle_Ear", source="BIRNLEX:1695"} xref: UMLS:C1268972 {source="BIRNLEX:1695"} xref: VHOG:0000312 xref: Wikipedia:Middle_ear xref: XAO:0000191 is_a: UBERON:0034921 ! multi organ part structure relationship: BFO:0000050 UBERON:0001690 ! part of ear relationship: RO:0002433 UBERON:0001690 ! contributes to morphology of ear [Term] id: UBERON:0001757 name: pinna def: "The part of the ear that projects from the head, connecting to the external acoustic meatus." [http://orcid.org/0000-0002-6601-2165, Wikipedia:Pinna_(anatomy)] subset: pheno_slim subset: uberon_slim synonym: "auricle" EXACT [] synonym: "auricle of ear" EXACT [] synonym: "auricle of external ear" EXACT [] synonym: "auricula" EXACT [Wikipedia:Auricula] synonym: "auricula (auris externa)" EXACT [] synonym: "pinna of ear" EXACT [] synonym: "pinnae" RELATED OMO:0003004 [] xref: EHDAA2:0001467 xref: EMAPA:17589 xref: EV:0100355 xref: FMA:56580 xref: galen:Auricle xref: MA:0000259 xref: NCIT:C32165 xref: SCTID:421159007 xref: UMLS:C0928075 {source="ncithesaurus:Auricle"} xref: VHOG:0000460 xref: Wikipedia:Pinna_(anatomy) is_a: BFO:0000002 is_a: UBERON:0001444 ! subdivision of head relationship: BFO:0000050 UBERON:0001691 ! part of external ear relationship: RO:0000086 PATO:0001297 ! has quality reflectivity relationship: RO:0002150 UBERON:0001352 ! continuous with external acoustic meatus relationship: RO:0002162 NCBITaxon:40674 ! in taxon Mammalia relationship: RO:0002202 UBERON:0006208 ! develops from auditory hillocks [Term] id: UBERON:0001758 name: periodontium def: "The tissues that invest or help to invest and support the teeth, including the periodontal ligament, gingivae, cementum, and alveolar and supporting bone[BTO]." [BTO:0001021, Wikipedia:Periodontium] subset: pheno_slim synonym: "paradentium" RELATED [MESH:A14.254.646] synonym: "periodontal ligament" RELATED INCONSISTENT [FMA:56665] synonym: "periodontal membrane" RELATED [MA:0002467] synonym: "tooth supporting structure" RELATED [MESH:A14.254.646] xref: BTO:0001021 xref: CALOHA:TS-2380 xref: GAID:216 xref: MESH:D010519 xref: NCIT:C33304 xref: UMLS:C0031093 {source="ncithesaurus:Periodontium"} xref: Wikipedia:Periodontium is_a: BFO:0000002 is_a: UBERON:0000479 {source="cjm"} ! tissue relationship: BFO:0000050 UBERON:0003672 {source="cjm"} ! part of dentition relationship: BFO:0000051 CL:0002166 {source="FMA"} ! has part epithelial cell of Malassez relationship: RO:0002220 UBERON:0001091 ! adjacent to calcareous tooth property_value: foaf:depiction "https://upload.wikimedia.org/wikipedia/commons/d/dc/The_Periodontium.jpg" xsd:anyURI [Term] id: UBERON:0001759 name: vagus nerve def: "Cranial nerve that branches into the lateral (to body sense organs) and the intestino-accessorial (to the skin, muscles of shoulder, hyoid, larynx, gut, lungs, and heart)." [ISBN:0471209627, Wikipedia:Vagus_nerve] subset: efo_slim subset: human_reference_atlas subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "10n" BROAD OMO:0003000 [BIRNLEX:801, NIFSTD:NeuroNames_abbrevSource] synonym: "CN-X" RELATED [] synonym: "cranial nerve X" RELATED [] synonym: "nerve X" RELATED [NeuroNames:702] synonym: "nervus vagus" RELATED OMO:0003011 [BTO:0003472, Wikipedia:Vagus_nerve] synonym: "nervus vagus [x]" EXACT OMO:0003011 [FMA:5731, FMA:TA] synonym: "pneuomgastric nerve" RELATED [BTO:0003472] synonym: "tenth cranial nerve" EXACT [] synonym: "vagal nerve" RELATED [] synonym: "vagus" EXACT [] synonym: "vagus nerve [X]" EXACT [] synonym: "vagus nerve or its root" RELATED [BAMS:10n] synonym: "vagus nerve tree" EXACT [] synonym: "vagus X nerve" EXACT [MA:0001106] xref: AAO:0010475 xref: BAMS:10n xref: BAMS:Xn xref: BIRNLEX:801 xref: BTO:0003472 xref: EFO:0002549 xref: EMAPA:37797 {source="MA:th"} xref: FMA:5731 xref: GAID:721 xref: galen:VagusNerve xref: MA:0001106 xref: MBA:917 xref: MESH:D014630 xref: NCIT:C12812 xref: neuronames:702 {source="BIRNLEX:801"} xref: SCTID:362466001 xref: TAO:0000453 xref: UMLS:C0042276 {source="ncithesaurus:Vagus_Nerve", source="BIRNLEX:801"} xref: UMLS:C1305910 {source="BIRNLEX:801"} xref: VHOG:0000737 xref: Wikipedia:Vagus_nerve xref: XAO:0003097 xref: ZFA:0000453 is_a: UBERON:0001785 ! cranial nerve is_a: UBERON:0010314 ! structure with developmental contribution from neural crest intersection_of: UBERON:0001785 ! cranial nerve intersection_of: extends_fibers_into UBERON:0011775 ! vagus nerve nucleus relationship: BFO:0000050 UBERON:0001033 ! part of gustatory system relationship: extends_fibers_into UBERON:0002075 ! viscus relationship: extends_fibers_into UBERON:0011775 ! vagus nerve nucleus relationship: RO:0002254 UBERON:0005239 ! has developmental contribution from basal plate metencephalon property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/5/5e/Gray791.png" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "vagus nerve" xsd:string [Term] id: UBERON:0001763 name: odontogenic papilla def: "A condensation of odontoblasts that forms the part of a tooth germ that gives rise to dentin and pulp in the mature tooth. It lies below a cellular aggregation known as the enamel organ." [Wikipedia:Dental_papilla, ZFA:0005140] subset: uberon_slim subset: vertebrate_core synonym: "dental papilla" RELATED [MA:0001598] synonym: "dentinal papilla" RELATED [BTO:0001839] synonym: "dermal papilla" RELATED INCONSISTENT [ISBN:0073040584] synonym: "odontogenic condensation" EXACT [VSAO:0000025] synonym: "papilla dentis" RELATED OMO:0003011 [Wikipedia:Dental_papilla] synonym: "pharyngeal tooth mesenchyme" NARROW SENSU [ZFA:0005140] synonym: "tooth mesenchyme" RELATED [ZFA:0005140] xref: BTO:0001839 xref: EMAPA:32892 xref: FMA:57662 xref: GAID:1277 xref: MA:0001598 xref: MESH:D003771 xref: TAO:0005140 xref: VHOG:0001465 xref: VSAO:0000025 xref: Wikipedia:Dental_papilla xref: XAO:0004045 xref: ZFA:0005140 is_a: UBERON:0005856 ! developing mesenchymal condensation is_a: UBERON:0007213 ! mesenchyme derived from head neural crest intersection_of: UBERON:0005856 ! developing mesenchymal condensation intersection_of: BFO:0000050 UBERON:0008281 ! part of tooth bud intersection_of: RO:0002473 CL:0007003 ! composed primarily of preodontoblast relationship: BFO:0000050 UBERON:0008281 ! part of tooth bud relationship: BSPO:0001107 UBERON:0005176 ! tooth enamel organ relationship: RO:0002202 UBERON:0003856 {source="ZFA"} ! develops from uncondensed odontogenic mesenchyme relationship: RO:0002473 CL:0007003 ! composed primarily of preodontoblast property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/2/22/Gray1011.png" xsd:anyURI [Term] id: UBERON:0001765 name: mammary duct def: "Epithelial tube that transports milk[GO]." [GO:0060603, Wikipedia:Lactiferous_duct] comment: This structure regresses in most males subset: pheno_slim subset: uberon_slim synonym: "ductus lactiferi" RELATED OMO:0003011 [BTO:0002845, Wikipedia:Lactiferous_duct] synonym: "galactophorous duct" RELATED [Wikipedia:Lactiferous_duct] synonym: "galactophorous tubule" RELATED [BTO:0002845] synonym: "lactiferous duct" EXACT [FMA:58006] synonym: "lactiferous gland duct" EXACT [OBOL:automatic] synonym: "lactiferous tubule" RELATED [BTO:0002845] synonym: "mammary gland duct" EXACT [MA:0000791] synonym: "mammilary duct" RELATED [Wikipedia:Lactiferous_duct] xref: BTO:0002845 xref: CALOHA:TS-2385 xref: EMAPA:35538 xref: FMA:58006 xref: MA:0000791 xref: NCIT:C32910 xref: SCTID:361719004 xref: UMLS:C0222613 {source="ncithesaurus:Lactiferous_Duct"} xref: Wikipedia:Lactiferous_duct is_a: UBERON:0000058 ! duct is_a: UBERON:0003244 ! epithelium of mammary gland is_a: UBERON:0003914 ! epithelial tube intersection_of: UBERON:0000058 ! duct intersection_of: BFO:0000050 UBERON:0001911 ! part of mammary gland relationship: channel_for UBERON:0001913 ! milk relationship: channels_into UBERON:0002030 ! nipple property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/6/64/Illu_breast_anatomy.jpg" xsd:anyURI [Term] id: UBERON:0001766 name: anterior chamber of eyeball def: "The space in the eye, filled with aqueous humor, and bounded anteriorly by the cornea and a small portion of the sclera and posteriorly by a small portion of the ciliary body, the iris, and part of the crystalline lens." [MESH:A09.371.060.067, MP:0005205] subset: pheno_slim synonym: "anterior chamber" EXACT [HP:0000593, MP:0010709] synonym: "anterior chamber of eye" EXACT [] synonym: "camera anterior" EXACT [] synonym: "camera anterior bulbi" RELATED [BTO:0002084] synonym: "camera anterior bulbi oculi" RELATED OMO:0003011 [Wikipedia:Anterior_chamber_of_eyeball] synonym: "camera oculi anterior" RELATED [BTO:0002084] synonym: "eye anterior chamber" EXACT [] xref: BTO:0002084 xref: EHDAA2:0000129 xref: EHDAA:9033 xref: EMAPA:18231 xref: FMA:58078 xref: GAID:889 xref: MA:0000262 xref: MESH:D000867 xref: NCIT:C12667 xref: SCTID:181160009 xref: UMLS:C0003151 {source="ncithesaurus:Anterior_Chamber_of_the_Eye"} xref: VHOG:0001431 xref: Wikipedia:Anterior_chamber_of_eyeball is_a: UBERON:0006311 {source="FMA"} ! chamber of eyeball relationship: BFO:0000050 UBERON:0001801 ! part of anterior segment of eyeball relationship: RO:0002433 UBERON:0001801 ! contributes to morphology of anterior segment of eyeball property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/1/1e/Schematic_diagram_of_the_human_eye_en.svg" xsd:anyURI property_value: skos:prefLabel "anterior chamber of eyeball" xsd:string [Term] id: UBERON:0001768 name: uvea def: "The pigmented middle of the three concentric layers that make up an eye, consisting of the iris, ciliary body and choroid[WP,edited]." [MP:0005197, Wikipedia:Uvea] subset: pheno_slim subset: uberon_slim synonym: "pars iridica retinae" RELATED [Wikipedia:Uvea] synonym: "tunica vasculatis oculi" RELATED [Wikipedia:Uvea] synonym: "tunica vasculosa bulbi" RELATED OMO:0003011 [Wikipedia:Uvea] synonym: "tunica vasculosa of eyeball" EXACT [FMA:58103] synonym: "uvea" EXACT [FMA:58103] synonym: "uveal tract" EXACT [FMA:58103] synonym: "vascular layer of eyeball" RELATED [FMA:58103] xref: CALOHA:TS-2228 xref: EMAPA:35901 xref: FMA:58103 xref: GAID:912 xref: MA:0002480 xref: MESH:D014602 xref: NCIT:C12811 xref: SCTID:280648000 xref: UMLS:C0042160 {source="ncithesaurus:Uvea"} xref: Wikipedia:Uvea is_a: UBERON:0004923 {source="FMA"} ! organ component layer is_a: UBERON:0010314 ! structure with developmental contribution from neural crest relationship: BFO:0000050 UBERON:0000019 ! part of camera-type eye relationship: BFO:0000051 UBERON:0001769 ! has part iris relationship: BFO:0000051 UBERON:0001775 ! has part ciliary body relationship: BFO:0000051 UBERON:0001776 ! has part optic choroid property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/e/eb/Gray869.png" xsd:anyURI property_value: IAO:0000116 "TODO - check child terms, isa vs partof. See also MA:0001284 ! tunica vasculosa plexus" xsd:string property_value: RO:0002175 NCBITaxon:7955 {source="DOI:10.1177/0192623311409597"} property_value: skos:prefLabel "uvea" xsd:string [Term] id: UBERON:0001769 name: iris def: "The adjustable membrane, composed of the stroma and pigmented epithelium, located just in front of the crystalline lens within the eye." [ISBN:0-683-40008-8, MP:0001322] subset: efo_slim subset: human_reference_atlas subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "anterior uvea" RELATED [] synonym: "irides" RELATED OMO:0003004 [] synonym: "irises" RELATED OMO:0003004 [VHOG:0000101] xref: AAO:0010347 xref: BTO:0000653 xref: CALOHA:TS-0491 xref: EFO:0004245 xref: EMAPA:19154 xref: EV:0100345 xref: FMA:58235 xref: GAID:917 xref: MA:0000273 xref: MESH:D007498 xref: NCIT:C12737 xref: SCTID:181164000 xref: TAO:0001238 xref: UMLS:C0022077 {source="ncithesaurus:Iris"} xref: VHOG:0000101 xref: Wikipedia:Iris_(anatomy) xref: XAO:0000185 xref: ZFA:0001238 is_a: UBERON:0000481 ! multi-tissue structure is_a: UBERON:0004121 ! ectoderm-derived structure relationship: BFO:0000050 UBERON:0011892 ! part of anterior uvea relationship: RO:0002202 UBERON:0004128 {source="XAO"} ! develops from optic vesicle relationship: RO:0002433 UBERON:0011892 ! contributes to morphology of anterior uvea property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "iris" xsd:string [Term] id: UBERON:0001770 name: lacrimal canaliculus def: "The part of the lacrimal duct that connects the lacrimal punctum to the lacrimal sac." [http://orcid.org/0000-0002-6601-2165] subset: uberon_slim synonym: "canaliculus lacrimalis" RELATED OMO:0003011 [Wikipedia:Lacrimal_canaliculi] synonym: "lacrimal duct" RELATED [https://www.bartleby.com/lit-hub/anatomy-of-the-human-body/fig-896/, ISBN:1587341026] xref: EMAPA:37624 {source="MA:th"} xref: FMA:58245 xref: MA:0001294 xref: NCIT:C32907 xref: SCTID:263348000 xref: UMLS:C0459631 {source="ncithesaurus:Lacrimal_Canaliculus"} xref: Wikipedia:Lacrimal_canaliculi is_a: UBERON:0004111 ! anatomical conduit relationship: BFO:0000050 UBERON:0001850 {source="FMA"} ! part of lacrimal drainage system relationship: RO:0002176 UBERON:0001351 ! connects lacrimal sac relationship: RO:0002176 UBERON:0010284 ! connects lacrimal punctum [Term] id: UBERON:0001772 name: corneal epithelium def: "The smooth stratified squamous epithelium that covers the outer surface of the cornea." [MESH:A09.371.060.217.325, MGI:smb, MP:0006000] subset: efo_slim subset: human_reference_atlas subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "anterior corneal epithelium" EXACT [] synonym: "anterior endothelium of cornea" RELATED [BTO:0000287] synonym: "cornea epithelial tissue" EXACT [OBOL:automatic] synonym: "cornea epithelium" EXACT [OBOL:automatic] synonym: "e. anterius corneae" RELATED OMO:0003011 [Wikipedia:Corneal_epithelium] synonym: "endothelium anterius corneae" RELATED [BTO:0000287] synonym: "endothelium camerae anterioris bulbi" RELATED [BTO:0000287] synonym: "endothelium corneale" RELATED [BTO:0000287] synonym: "epithelial tissue of cornea" EXACT [OBOL:automatic] synonym: "epithelium anterius (cornea)" EXACT [] synonym: "epithelium anterius corneae" EXACT OMO:0003011 [FMA:58263, FMA:TA] synonym: "epithelium corneæ anterior layer" EXACT [] synonym: "epithelium of cornea" EXACT [] synonym: "epithelium posterius corneae" RELATED [BTO:0000287] synonym: "external epithelium of cornea" EXACT [] xref: BTO:0000287 xref: CALOHA:TS-0173 xref: EFO:0001917 xref: EHDAA2:0000319 xref: EMAPA:17162 xref: FMA:58263 xref: GAID:895 xref: MA:0001243 xref: MESH:D019573 xref: NCIT:C12928 xref: SCTID:368825001 xref: TAO:0002187 xref: UMLS:C0459875 {source="ncithesaurus:Corneal_Epithelium"} xref: Wikipedia:Corneal_epithelium xref: ZFA:0001683 is_a: BFO:0000002 is_a: UBERON:0015808 ! eye epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: RO:0002007 UBERON:0000964 ! bounding layer of cornea relationship: RO:0002007 UBERON:0000964 ! bounding layer of cornea relationship: RO:0002202 UBERON:0000076 {source="ISBN:0781772214"} ! develops from external ectoderm relationship: RO:0002433 UBERON:0000964 ! contributes to morphology of cornea property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/6/66/Gray871.png" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "corneal epithelium" xsd:string [Term] id: UBERON:0001773 name: sclera def: "Opaque fibrous outer layer of the eyeball[ZFA,Kardong,WP]." [Wikipedia:Sclera, ZFIN:ZDB-PUB-050701-15] comment: Disease notes: implicated in rheumatoid arthritis. subset: human_reference_atlas subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "scleral capsule" RELATED [] xref: AAO:0010354 xref: BTO:0001606 xref: EMAPA:19027 xref: EV:0100342 xref: FMA:58269 xref: GAID:911 xref: MA:0000280 xref: MESH:D012590 xref: NCIT:C12784 xref: SCTID:181163006 xref: UMLS:C0036410 {source="ncithesaurus:Sclera"} xref: VHOG:0001274 xref: Wikipedia:Sclera xref: XAO:0000183 xref: ZFA:0005563 is_a: BFO:0000002 is_a: UBERON:0000064 ! organ part relationship: BFO:0000050 UBERON:0012430 {source="FMA"} ! part of tunica fibrosa of eyeball relationship: BFO:0000051 CL:0000347 {source="ZFA"} ! has part scleral cell relationship: RO:0000086 PATO:0000963 ! has quality opaque relationship: RO:0002202 UBERON:0003314 {source="ISBN:0781772214"} ! develops from eye mesenchyme relationship: RO:0002202 UBERON:0007213 ! develops from mesenchyme derived from head neural crest relationship: RO:0002433 UBERON:0000019 ! contributes to morphology of camera-type eye property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/1/1e/Schematic_diagram_of_the_human_eye_en.svg" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "sclera" xsd:string [Term] id: UBERON:0001774 name: skeletal muscle of trunk def: "A skeletal muscle organ that is part of the trunk region." [http://orcid.org/0000-0002-6601-2165] subset: uberon_slim subset: vertebrate_core synonym: "body musculature" EXACT [ZFA:0000473] synonym: "muscle of trunk" EXACT [FMA:58274] synonym: "muscle organ of torso" EXACT [OBOL:automatic] synonym: "muscle organ of trunk" EXACT [OBOL:automatic] synonym: "torso muscle organ" EXACT [OBOL:automatic] synonym: "trunk muscle" EXACT [] synonym: "trunk muscle organ" EXACT [OBOL:automatic] synonym: "trunk musculature" EXACT [] xref: AAO:0000611 xref: EMAPA:35888 xref: FMA:58274 xref: MA:0000514 xref: TAO:0000473 xref: XAO:0003230 xref: ZFA:0000473 is_a: UBERON:0005177 ! trunk region element is_a: UBERON:0014892 ! skeletal muscle organ, vertebrate intersection_of: UBERON:0014892 ! skeletal muscle organ, vertebrate intersection_of: BFO:0000050 UBERON:0002100 ! part of trunk relationship: BFO:0000050 UBERON:0004479 {source="prolog"} ! part of musculature of trunk property_value: IAO:0000116 "Note that this class excludes smooth muscle elements in the trunk region, such as the internal anal sphincter. This appears to be consistent with other ontologies such as FMA and ZFA which appear to only include skeletal muscles here. In fact the MA class 'trunk muscle' is classified as a 'set of skeletal muscles'." xsd:string property_value: skos:prefLabel "skeletal muscle of trunk" xsd:string [Term] id: UBERON:0001775 name: ciliary body def: "The thickened portion of the vascular tunic, which lies between the choroid and the iris, composed of ciliary muscle and ciliary processes." [ISBN:0-683-40008-8, MP:0005099, Wikipedia:Ciliary_body] subset: human_reference_atlas subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "anterior uvea" RELATED [] synonym: "ciliary bodies" RELATED OMO:0003004 [VHOG:0000102] synonym: "corpus ciliare" RELATED OMO:0003011 [Wikipedia:Ciliary_body] synonym: "ocular ciliary body" EXACT [] xref: AAO:0010341 xref: BTO:0000260 xref: CALOHA:TS-0694 xref: EMAPA:19065 xref: EV:0100346 xref: FMA:58295 xref: GAID:916 xref: MA:0000264 xref: MESH:D002924 xref: NCIT:C12345 xref: neuronames:1571 xref: SCTID:263340007 xref: UMLS:C0008779 {source="ncithesaurus:Ciliary_Body"} xref: VHOG:0000102 xref: Wikipedia:Ciliary_body xref: XAO:0000186 is_a: UBERON:0000481 ! multi-tissue structure is_a: UBERON:0004121 ! ectoderm-derived structure is_a: UBERON:0010314 ! structure with developmental contribution from neural crest relationship: BFO:0000050 UBERON:0011892 ! part of anterior uvea relationship: BFO:0000051 UBERON:0001605 ! has part ciliary muscle relationship: BFO:0000051 UBERON:0010427 ! has part ciliary processes relationship: RO:0002202 UBERON:0002346 {source="ISBN:0781772214"} ! develops from neurectoderm relationship: RO:0002433 UBERON:0011892 ! contributes to morphology of anterior uvea property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/1/1e/Schematic_diagram_of_the_human_eye_en.svg" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "ciliary body" xsd:string [Term] id: UBERON:0001776 name: optic choroid def: "Vascular layer containing connective tissue, of the eye lying between the retina and the sclera. The choroid provides oxygen and nourishment to the outer layers of the retina. Along with the ciliary body and iris, the choroid forms the uveal tract[WP]." [Wikipedia:Choroid] subset: human_reference_atlas subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "chorioid" RELATED [BTO:0001829] synonym: "choroid" EXACT [MA:0000263] synonym: "choroid coat" EXACT [Wikipedia:Choroid] synonym: "choroidea" EXACT [Wikipedia:Choroid] synonym: "choroidea" RELATED OMO:0003011 [Wikipedia:Choroid] synonym: "eye choroid" EXACT [VHOG:0001568] synonym: "optic choroid" RELATED [ZFA:0005229] synonym: "posterior uvea" EXACT [Wikipedia:Uvea#Regions] xref: BTO:0001829 xref: CALOHA:TS-2054 xref: EMAPA:19077 xref: EV:0100347 xref: FMA:58298 xref: GAID:913 xref: MA:0000263 xref: MESH:D002829 xref: NCIT:C12344 xref: SCTID:181172003 xref: TAO:0005229 xref: UMLS:C0008520 {source="ncithesaurus:Choroid"} xref: VHOG:0001568 xref: Wikipedia:Choroid xref: ZFA:0005229 is_a: UBERON:0002203 ! vasculature of eye disjoint_from: UBERON:0011892 {source="lexical"} ! anterior uvea relationship: BFO:0000050 UBERON:0001768 {source="MA"} ! part of uvea relationship: BFO:0000050 UBERON:0019207 ! part of chorioretinal region relationship: RO:0002131 UBERON:0001802 {source="Wikipedia"} ! overlaps posterior segment of eyeball relationship: RO:0002220 UBERON:0000966 ! adjacent to retina relationship: RO:0002220 UBERON:0001773 ! adjacent to sclera relationship: RO:0002220 UBERON:0011892 ! adjacent to anterior uvea relationship: RO:0002433 UBERON:0001768 ! contributes to morphology of uvea property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/1/1e/Schematic_diagram_of_the_human_eye_en.svg" xsd:anyURI property_value: IAO:0000116 "check choroid vs choroid layer; check ZFA/TAO placement - no homology assertion in VHOG. Note this is entirely in the posterior region of eyeball in ZFA" xsd:string property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "optic choroid" xsd:string [Term] id: UBERON:0001777 name: substantia propria of cornea def: "The lamellated connective tissue of the cornea between the Bowman and Descemet membranes." [ISBN:0-683-40008-8, MESH:A09.371.060.217.228, MP:0005300] subset: efo_slim subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "corneal stroma" EXACT [MA:0001245] synonym: "stroma of cornea" EXACT [] synonym: "substantia propria" BROAD [] synonym: "substantia propria corneae" EXACT OMO:0003011 [FMA:58306, FMA:TA] xref: CALOHA:TS-1138 xref: EFO:0002514 xref: EMAPA:17602 xref: FMA:58306 xref: GAID:893 xref: MA:0001245 xref: MESH:D003319 xref: NCIT:C12699 xref: SCTID:362511000 xref: TAO:0002189 xref: UMLS:C0010040 {source="ncithesaurus:Corneal_Stroma"} xref: Wikipedia:Corneal_stroma xref: ZFA:0001685 is_a: BFO:0000002 is_a: UBERON:0003891 ! stroma intersection_of: UBERON:0003891 ! stroma intersection_of: BFO:0000050 UBERON:0000964 ! part of cornea relationship: BFO:0000050 UBERON:0000964 ! part of cornea relationship: RO:0002202 UBERON:0007213 ! develops from mesenchyme derived from head neural crest relationship: RO:0002220 UBERON:0004367 ! adjacent to Descemet's membrane relationship: RO:0002220 UBERON:0004370 ! adjacent to anterior limiting lamina of cornea relationship: RO:0002433 UBERON:0000964 ! contributes to morphology of cornea property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/6/66/Gray871.png" xsd:anyURI [Term] id: UBERON:0001778 name: ciliary epithelium def: "A double layer covering the ciliary body that produces aqueous humor." [Wikipedia:Ciliary_body#Ciliary_epithelium] subset: human_reference_atlas synonym: "ciliary body epithelium" EXACT [FMA:58464] synonym: "epithelium of ciliary body" EXACT [FMA:58464] synonym: "ocular ciliary epithelium" EXACT [] xref: BTO:0001770 xref: CALOHA:TS-0695 xref: EMAPA:35239 xref: FMA:58464 xref: MA:0001238 xref: NCIT:C32314 xref: SCTID:280870004 xref: UMLS:C0459736 {source="ncithesaurus:Ciliary_Epithelium"} xref: Wikipedia:Ciliary_body#Ciliary_epithelium is_a: UBERON:0000488 {source="FMA"} ! atypical epithelium is_a: UBERON:0015808 ! eye epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: BFO:0000050 UBERON:0001775 ! part of ciliary body relationship: BFO:0000050 UBERON:0001775 {source="MA"} ! part of ciliary body relationship: BFO:0000051 GO:0048770 {source="MP"} ! has part pigment granule relationship: RO:0003000 UBERON:0001796 {source="Wikipedia"} ! produces aqueous humor of eyeball property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "ciliary epithelium" xsd:string [Term] id: UBERON:0001779 name: iris stroma def: "The delicate vascular connective tissue that lies between the anterior surface of the iris and the pars iridica retinae." [http://www.drugs.com/dict/stroma-of-iris.html, Wikipedia:Iris_stroma] subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "iridial stroma" EXACT [] synonym: "stroma of iris" EXACT [] xref: EMAPA:35451 xref: FMA:58526 xref: MA:0002777 xref: SCTID:280882008 xref: Wikipedia:Iris_stroma xref: ZFA:0005569 is_a: UBERON:0003891 ! stroma intersection_of: UBERON:0003891 ! stroma intersection_of: BFO:0000050 UBERON:0001769 ! part of iris relationship: BFO:0000050 UBERON:0001769 ! part of iris relationship: RO:0002433 UBERON:0001769 ! contributes to morphology of iris property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/5/55/Gray883.png" xsd:anyURI [Term] id: UBERON:0001780 name: spinal nerve def: "The any of the paired peripheral nerves formed by the union of the dorsal and ventral spinal roots from each spinal cord segment[MP,modified]." [MESH:A08.800.800.720, MP:0001077] subset: human_reference_atlas subset: pheno_slim subset: uberon_slim synonym: "backbone nerve" EXACT [OBOL:automatic] synonym: "nerve of backbone" EXACT [OBOL:automatic] synonym: "nerve of spinal column" EXACT [OBOL:automatic] synonym: "nerve of spine" EXACT [OBOL:automatic] synonym: "nerve of vertebral column" EXACT [OBOL:automatic] synonym: "nervi spinales" RELATED OMO:0003011 [Wikipedia:Spinal_nerve] synonym: "spinal column nerve" EXACT [OBOL:automatic] synonym: "spinal nerve tree" EXACT [] synonym: "spinal nerves" RELATED OMO:0003004 [BAMS:spin] synonym: "spine nerve" EXACT [OBOL:automatic] synonym: "vertebral column nerve" EXACT [OBOL:automatic] xref: AAO:0011101 xref: BAMS:spin xref: BTO:0000870 xref: EHDAA2:0001898 xref: EMAPA:16989 xref: FMA:5858 xref: GAID:841 xref: MA:0000233 xref: MESH:D013127 xref: NCIT:C12792 xref: neuronames:1228 xref: SCTID:361099009 xref: UMLS:C0037941 {source="ncithesaurus:Spinal_Nerve"} xref: VHOG:0000824 xref: Wikipedia:Spinal_nerve xref: XAO:0003101 is_a: UBERON:0001021 ! nerve intersection_of: UBERON:0001021 ! nerve intersection_of: extends_fibers_into UBERON:0002240 ! spinal cord relationship: extends_fibers_into UBERON:0002240 ! spinal cord property_value: foaf:depiction "https://upload.wikimedia.org/wikipedia/commons/d/d2/Spinal_nerve.svg" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "spinal nerve" xsd:string [Term] id: UBERON:0001781 name: layer of retina def: "Any of the layers that make up the retina[MP]." [MP:0003727] subset: pheno_slim subset: vertebrate_core synonym: "retina layer" EXACT [] synonym: "retina neuronal layer" EXACT [MP:0006069] synonym: "retinal layer" EXACT [] synonym: "retinal neuronal layer" EXACT [MP:0006069] xref: AAO:0010353 xref: EMAPA:35742 xref: FMA:58617 xref: MA:0001319 xref: NCIT:C49328 xref: SCTID:280657006 xref: UMLS:C0459649 {source="ncithesaurus:Retina_Layer"} xref: XAO:0000266 is_a: UBERON:0022303 ! nervous system cell part layer relationship: BFO:0000050 UBERON:0000966 ! part of retina relationship: RO:0002433 UBERON:0000966 ! contributes to morphology of retina property_value: skos:prefLabel "layer of retina" xsd:string [Term] id: UBERON:0001782 name: pigmented layer of retina def: "A monolayer of pigmented epithelium covering the neural retina; develops from the outer of the two layers of the optic cup[ZFA]. the pigmented cell layer just outside the neurosensory retina that nourishes retinal visual cells, and is firmly attached to the underlying choroid and overlying retinal visual cells[WP]." [Wikipedia:Retinal_pigment_epithelium, ZFIN:curator] subset: human_reference_atlas subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "epithelium, retinal pigment" RELATED [BTO:0001177] synonym: "outer pigmented layer of retina" EXACT [] synonym: "p. pigmentosa retinae" RELATED OMO:0003011 [Wikipedia:Retinal_pigment_epithelium] synonym: "pigment epithelium of retina" EXACT [] synonym: "pigmented epithelium" RELATED [] synonym: "pigmented retina" RELATED [] synonym: "pigmented retina epithelium" EXACT [] synonym: "pigmented retinal epithelium" EXACT [] synonym: "PRE" RELATED [] synonym: "retinal pigment epithelium" EXACT [MP:0005201, Wikipedia:Retinal_pigment_epithelium] synonym: "retinal pigment layer" RELATED [VHOG:0000536] synonym: "retinal pigmented epithelium" EXACT [ZFA:0000144] synonym: "RPE" RELATED [] synonym: "stratum pigmentosa retinae" RELATED OMO:0003011 [Wikipedia:Retinal_pigment_epithelium] synonym: "stratum pigmentosum (retina)" EXACT [] synonym: "stratum pigmentosum retinae" EXACT OMO:0003011 [FMA:58627, FMA:TA] xref: AAO:0011096 xref: BTO:0001177 xref: CALOHA:TS-0869 xref: EHDAA2:0001465 xref: EHDAA:4765 xref: EMAPA:17172 xref: EMAPA:35738 xref: FMA:58627 xref: MA:0000279 xref: MA:0003173 xref: NCIT:C33470 xref: SCTID:280662007 xref: TAO:0000144 xref: UMLS:C0035322 {source="ncithesaurus:Retinal_Pigment_Epithelium"} xref: VHOG:0000536 xref: Wikipedia:Retinal_pigment_epithelium xref: XAO:0003217 xref: ZFA:0000144 is_a: UBERON:0000957 ! lamina is_a: UBERON:0001781 ! layer of retina is_a: UBERON:0010371 ! ecto-epithelium is_a: UBERON:0015808 ! eye epithelium intersection_of: UBERON:0001781 ! layer of retina intersection_of: RO:0002495 UBERON:0005424 ! immediate transformation of presumptive retinal pigmented epithelium relationship: BFO:0000051 GO:0048770 ! has part pigment granule relationship: RO:0002220 UBERON:0001787 {source="Wikipedia"} ! adjacent to photoreceptor layer of retina relationship: RO:0002220 UBERON:0003902 ! adjacent to retinal neural layer relationship: RO:0002495 UBERON:0005424 ! immediate transformation of presumptive retinal pigmented epithelium property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/5/55/Gray881.png" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001785 name: cranial nerve def: "Cranial nerves are nerves that emerge directly from the brain, in contrast to spinal nerves, which emerge from segments of the spinal cord." [Wikipedia:Cranial_nerve] subset: human_reference_atlas subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "cranial nerves" RELATED [] synonym: "cranial neural tree organ" EXACT [] synonym: "nervus cranialis" RELATED OMO:0003011 [Wikipedia:Cranial_nerve] xref: AAO:0000108 xref: BAMS:cran xref: BIRNLEX:1623 xref: BTO:0001104 xref: EHDAA2:0000323 xref: EMAPA:17264 xref: FMA:5865 xref: GAID:802 xref: MA:0000215 xref: MBA:967 xref: MESH:D003391 xref: NCIT:C12700 xref: neuronames:1227 xref: SCTID:244447006 xref: TAO:0000641 xref: UMLS:C0010268 {source="BIRNLEX:1623", source="ncithesaurus:Cranial_Nerve"} xref: UMLS:C1269897 {source="BIRNLEX:1623"} xref: VHOG:0000279 xref: Wikipedia:Cranial_nerve xref: XAO:0000429 xref: XAO:0003089 xref: ZFA:0000641 is_a: BFO:0000002 is_a: UBERON:0011779 ! nerve of head region is_a: UBERON:0034713 ! cranial neuron projection bundle intersection_of: UBERON:0001021 ! nerve intersection_of: BSPO:0000096 UBERON:0001780 ! spinal nerve intersection_of: extends_fibers_into UBERON:0000955 ! brain relationship: BSPO:0000096 UBERON:0001780 ! spinal nerve relationship: RO:0002254 UBERON:0003099 ! has developmental contribution from cranial neural crest property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/1/18/Brain_human_normal_inferior_view_with_labels_en-2.svg" xsd:anyURI property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/8/84/Brain_human_normal_inferior_view_with_labels_en.svg" xsd:anyURI property_value: IAO:0000116 "classified as neural tree organ, not nerve in FMA. CN II poses a challenge here as it is not strictly a nerve, yet is expected to be classified under CN." xsd:string property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "cranial nerve" xsd:string [Term] id: UBERON:0001786 name: fovea centralis def: "A depression in the inner retinal surface within the macula lutea, the photoreceptor layer of which is entirely cones and which is specialized for maximum visual acuity." [http://orcid.org/0000-0002-6601-2165, Wikipedia:Fovea] subset: pheno_slim subset: uberon_slim synonym: "centre of fovea" RELATED [BIRNLEX:2543] synonym: "centre of macula" EXACT [BIRNLEX:2543] synonym: "fovea" BROAD [] synonym: "fovea centralis in macula" EXACT [Wikipedia:Fovea_centralis_in_macula] xref: BIRNLEX:2543 xref: CALOHA:TS-2055 xref: EMAPA:37589 {source="MA:th"} xref: EV:0100350 xref: FMA:58658 xref: GAID:910 xref: MA:0001307 xref: MESH:D005584 xref: NCIT:C26463 xref: SCTID:264479005 xref: UMLS:C0016622 {source="ncithesaurus:Fovea_Centralis", source="BIRNLEX:2543"} xref: UMLS:C0450290 {source="BIRNLEX:2543"} xref: VHOG:0001572 xref: Wikipedia:Fovea_centralis_in_macula is_a: BFO:0000002 is_a: UBERON:0000064 ! organ part relationship: BFO:0000050 UBERON:0000053 ! part of macula lutea relationship: BFO:0000051 CHEBI:27547 ! has part relationship: BFO:0000051 CHEBI:28838 ! has part relationship: BFO:0000051 CL:0000573 ! has part retinal cone cell property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/1/1e/Schematic_diagram_of_the_human_eye_en.svg" xsd:anyURI [Term] id: UBERON:0001787 name: photoreceptor layer of retina def: "The layer within the retina where the photoreceptor cell receptor segments reside." [Wikipedia:Layer_of_rods_and_cones, ZFA:0000143] subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "layer of rods and cones" RELATED [] synonym: "retina photoreceptor layer" EXACT [] synonym: "retinal photoreceptor layer" EXACT [ZFA:0000143] synonym: "retinal photoreceptor layers" RELATED OMO:0003004 [ZFA:0000143] synonym: "stratum segmentorum externorum et internorum (retina)" EXACT [] synonym: "stratum segmentorum externorum et internorum retinae" EXACT OMO:0003011 [FMA:58680, FMA:TA] xref: EMAPA:35686 xref: FMA:58680 xref: MA:0001308 xref: NCIT:C32954 xref: TAO:0000143 xref: UMLS:C0229206 {source="ncithesaurus:Layer_of_the_Rods_and_Cones"} xref: VHOG:0001165 xref: Wikipedia:Layer_of_rods_and_cones xref: XAO:0003215 xref: ZFA:0000143 is_a: UBERON:0001781 ! layer of retina relationship: BFO:0000050 UBERON:0003902 ! part of retinal neural layer relationship: BFO:0000051 CL:0000287 {source="ZFA"} ! has part eye photoreceptor cell relationship: RO:0002220 UBERON:0001788 ! adjacent to outer limiting layer of retina property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/5/55/Gray881.png" xsd:anyURI [Term] id: UBERON:0001788 name: outer limiting layer of retina def: "The row of jucntional complexes between the plasma membranes of rod segments and the Muller glia cells; this barrier separates the layer of inner and outer segments of the rods and cones from the outer nuclear layer and forms a blood-retina barrier[MP]." [https://github.com/obophenotype/mammalian-phenotype-ontology/issues/2109, MP:0010236] subset: pheno_slim subset: vertebrate_core synonym: "blood retina barrier" RELATED [https://github.com/obophenotype/mammalian-phenotype-ontology/issues/2109] synonym: "BRB" RELATED OMO:0003000 [https://github.com/obophenotype/mammalian-phenotype-ontology/issues/2109] synonym: "external limiting lamina of retina" EXACT [] synonym: "external limiting membrane" EXACT [ZFA:0001331] synonym: "external limiting membrane of retina" EXACT [] synonym: "outer limiting membrane" EXACT [XAO:0003224] synonym: "outer limiting membrane of retina" EXACT [] synonym: "outer limiting membranes" RELATED OMO:0003004 [ZFA:0001331] synonym: "retina external limiting lamina" EXACT [] synonym: "retina outer limiting membrane" EXACT [MP:0010236] synonym: "stratum limitans externum (retina)" EXACT [] synonym: "stratum limitans externum retinae" EXACT OMO:0003011 [FMA:58683, FMA:TA] xref: EMAPA:36518 xref: FMA:58683 xref: MA:0001309 xref: NCIT:C33235 xref: SCTID:280676008 xref: TAO:0001331 xref: UMLS:C1518685 {source="ncithesaurus:Outer_Limiting_Membrane"} xref: Wikipedia:External_limiting_membrane xref: XAO:0003224 xref: ZFA:0001331 is_a: UBERON:0007619 {source="MA"} ! limiting membrane of retina relationship: RO:0002220 UBERON:0001789 ! adjacent to outer nuclear layer of retina [Term] id: UBERON:0001789 name: outer nuclear layer of retina def: "The layer within the retina where the photoreceptor cell bodies reside." [ZFA:0001464] subset: human_reference_atlas subset: pheno_slim subset: vertebrate_core synonym: "external nuclear layer" RELATED [BTO:0005600] synonym: "layer of outer granules" RELATED [BTO:0005600] synonym: "neural retina outer nuclear layer" EXACT [EMAPA:19157] synonym: "ONL" NARROW [] synonym: "outer nuclear layer" BROAD [] synonym: "retina outer nuclear layer" EXACT [] synonym: "retina, outer nuclear layer" RELATED [BAMS:Ronl] synonym: "retinal outer nuclear layer" EXACT [] synonym: "retinal outer nuclear layers" RELATED OMO:0003004 [ZFA:0001464] synonym: "stratum nucleare externum (retina)" EXACT [] synonym: "stratum nucleare externum retinae" EXACT OMO:0003011 [FMA:58684, FMA:TA] xref: BAMS:Ronl xref: BTO:0005600 xref: EMAPA:19157 xref: FMA:58684 xref: MA:0001315 xref: NCIT:C33236 xref: SCTID:280678009 xref: TAO:0001464 xref: UMLS:C0229210 {source="ncithesaurus:Outer_Nuclear_Layer_of_Retina"} xref: VHOG:0001170 xref: Wikipedia:Outer_nuclear_layer xref: XAO:0003219 xref: ZFA:0001464 is_a: UBERON:0001781 ! layer of retina relationship: BFO:0000050 UBERON:0003902 ! part of retinal neural layer relationship: RO:0002131 CL:0000287 ! overlaps eye photoreceptor cell relationship: RO:0002220 UBERON:0001790 ! adjacent to outer plexiform layer of retina relationship: RO:0002433 UBERON:0003902 ! contributes to morphology of retinal neural layer property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001790 name: outer plexiform layer of retina def: "The layer within the retina where the bipolar cells synapse with the photoreceptor cells[ZFA]. Between the inner and outer nuclear layers, the outer plexiform layer (OPL) contains connections between the photoreceptors and bipolar and horizontal cells[GO]." [ZFA:0001330] subset: pheno_slim subset: vertebrate_core synonym: "external plexiform layer" BROAD [BTO:0003174] synonym: "OPL" NARROW OMO:0003000 [] synonym: "outer plexiform layer" EXACT [BTO:0003174] synonym: "retina outer plexiform layer" EXACT [] synonym: "retina, outer plexiform layer" RELATED [BAMS:Ropl] synonym: "retinal outer plexiform layer" EXACT [] synonym: "retinal outer plexiform layers" RELATED OMO:0003004 [ZFA:0001330] synonym: "stratum plexiforme externum" EXACT [] synonym: "stratum plexiforme externum retinae" EXACT OMO:0003011 [FMA:58685, FMA:TA] xref: BAMS:Ropl xref: BTO:0003174 xref: EMAPA:35744 xref: FMA:58685 xref: MA:0001316 xref: NCIT:C33237 xref: SCTID:280684007 xref: TAO:0001330 xref: UMLS:C0229217 {source="ncithesaurus:Outer_Plexiform_Layer"} xref: VHOG:0001171 xref: Wikipedia:Outer_plexiform_layer xref: XAO:0003218 xref: ZFA:0001330 is_a: UBERON:0001781 ! layer of retina disjoint_from: UBERON:0005376 ! olfactory bulb external plexiform layer relationship: BFO:0000050 UBERON:0003902 ! part of retinal neural layer relationship: RO:0002220 UBERON:0001791 ! adjacent to inner nuclear layer of retina relationship: RO:0002433 UBERON:0003902 ! contributes to morphology of retinal neural layer [Term] id: UBERON:0001791 name: inner nuclear layer of retina def: "Cytoarchitectural layer of retina containing closely packed cell bodies, the majority of which are bipolar cells (adapted from Wikipedia)." [NLX:93816] comment: AO notes NLXANAT:1005031 appears to be retired subset: human_reference_atlas subset: pheno_slim subset: vertebrate_core synonym: "INL" NARROW [] synonym: "inner nuclear layer" EXACT [] synonym: "intermediate cell layer" EXACT [ZFA:0000119] synonym: "layer of inner granules" RELATED [NLX:93816] synonym: "neural retina inner nuclear layer" EXACT [EMAPA:19155] synonym: "retina inner nuclear layer" EXACT [] synonym: "retina, inner nuclear layer" RELATED [BAMS:Rinl] synonym: "retinal inner nuclear layer" EXACT [] synonym: "stratum nucleare internum" EXACT [] synonym: "stratum nucleare internum retinae" EXACT OMO:0003011 [FMA:58686, FMA:TA] xref: BAMS:Rinl xref: BTO:0003176 xref: EMAPA:19155 xref: FMA:58686 xref: MA:0001311 xref: NCIT:C32808 xref: NLX:93816 xref: NLXANAT:1005031 xref: SCTID:362520009 xref: TAO:0000119 xref: UMLS:C0229211 {source="ncithesaurus:Inner_Nuclear_Layer"} xref: VHOG:0001167 xref: Wikipedia:Inner_nuclear_layer xref: XAO:0003221 xref: ZFA:0000119 is_a: BFO:0000002 is_a: UBERON:0001781 ! layer of retina relationship: BFO:0000050 UBERON:0003902 ! part of retinal neural layer relationship: BFO:0000051 CL:0000561 ! has part amacrine cell relationship: BFO:0000051 CL:0000745 ! has part retina horizontal cell relationship: BFO:0000051 CL:0000748 ! has part retinal bipolar neuron relationship: RO:0002220 UBERON:0001795 ! adjacent to inner plexiform layer of retina relationship: RO:0002433 UBERON:0003902 ! contributes to morphology of retinal neural layer property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001792 name: ganglionic layer of retina def: "Cytoarchitectural layer of retina that contains somata of retinal ganglion cells, bounded by the stratum opticum and the inner plexiform layer." [NLX:36500] subset: human_reference_atlas subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "ganglion cell layer" BROAD [FMA:58687, ZFA:0000024] synonym: "ganglionic cell layer of retina" EXACT [FMA:58687] synonym: "GCL layer" EXACT [] synonym: "retina ganglion cell layer" EXACT [] synonym: "retina ganglion layer" EXACT [] synonym: "retina, ganglion cell layer" RELATED [BAMS:Rgcl] synonym: "retinal ganglion cell layer" EXACT [] synonym: "retinal ganglion layer" EXACT [MP:0008510] synonym: "RGC layer" EXACT [] synonym: "stratum ganglionicum (retina)" EXACT [FMA:58687] synonym: "stratum ganglionicum retinae" RELATED OMO:0003011 [Wikipedia:Ganglion_cell_layer] xref: BAMS:Rgcl xref: BTO:0003398 xref: CALOHA:TS-0867 xref: EMAPA:35739 xref: FMA:58687 xref: MA:0001310 xref: NCIT:C32652 xref: NLX:36500 xref: NLXANAT:1005030 xref: SCTID:280670002 xref: TAO:0000024 xref: VHOG:0001166 xref: Wikipedia:Ganglion_cell_layer xref: XAO:0003223 xref: ZFA:0000024 is_a: BFO:0000002 is_a: UBERON:0001781 {source="FMA"} ! layer of retina relationship: BFO:0000050 UBERON:0003902 {source="FMA"} ! part of retinal neural layer relationship: RO:0002220 UBERON:0001793 ! adjacent to nerve fiber layer of retina relationship: RO:0002433 UBERON:0003902 ! contributes to morphology of retinal neural layer relationship: RO:0002473 CL:0000740 ! composed primarily of retinal ganglion cell property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/5/55/Gray881.png" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001793 name: nerve fiber layer of retina def: "Layer of the retina formed by expansion of the fibers of the optic nerve." [ISBN:0-914294-08-3, MGI:smb] subset: pheno_slim subset: vertebrate_core synonym: "layer of nerve fibers of retina" EXACT [] synonym: "layer of nerve fibres of retina" EXACT [] synonym: "nerve fiber layer" BROAD [ZFA:0001619] synonym: "neural retina nerve fibre layer" RELATED [EMAPA:18591] synonym: "optic fiber layer" EXACT [DMBA:15652] synonym: "optic fiber layer" RELATED [VHOG:0001169] synonym: "optic fiber layers" RELATED OMO:0003004 [TAO:0002212] synonym: "retina nerve fiber layer" EXACT [] synonym: "stratum neurofibrarum (retina)" EXACT [] synonym: "stratum neurofibrarum retinae" EXACT OMO:0003011 [FMA:58688, FMA:TA] synonym: "stratum neurofibrum retinae" RELATED OMO:0003011 [Wikipedia:Nerve_fiber_layer] synonym: "stratum opticum of retina" EXACT [] xref: DMBA:15652 xref: EMAPA:18591 xref: FMA:58688 xref: MA:0001314 xref: SCTID:280671003 xref: TAO:0002212 xref: VHOG:0001169 xref: Wikipedia:Nervous_system_fiber_layer xref: XAO:0003220 xref: ZFA:0001619 is_a: UBERON:0001781 ! layer of retina relationship: BFO:0000050 UBERON:0003902 {source="FMA"} ! part of retinal neural layer relationship: RO:0002131 UBERON:0000941 ! overlaps cranial nerve II relationship: RO:0002220 UBERON:0001794 ! adjacent to inner limiting layer of retina relationship: RO:0002433 UBERON:0003902 ! contributes to morphology of retinal neural layer relationship: RO:0002473 GO:0030424 ! composed primarily of axon [Term] id: UBERON:0001794 name: inner limiting layer of retina def: "The row of fused Muller cell processes and astrocytes that separates the retinal nerve fiber layer from the vitreous[MP]." [MP:0010235] subset: pheno_slim subset: vertebrate_core synonym: "ILM" BROAD OMO:0003000 [ZFA:0001029] synonym: "inner limiting membrane" EXACT [XAO:0003222] synonym: "inner limiting membrane of retina" EXACT [] synonym: "inner limiting membranes" RELATED OMO:0003004 [ZFA:0001029] synonym: "internal limiting lamina of retina" EXACT [] synonym: "internal limiting membrane of retina" EXACT [] synonym: "retina inner limiting membrane" EXACT [MP:0010235] synonym: "retina internal limiting lamina" EXACT [] synonym: "stratum limitans internum retinae" EXACT OMO:0003011 [FMA:58689, FMA:TA] xref: EMAPA:36519 xref: FMA:58689 xref: MA:0001313 xref: NCIT:C32807 xref: SCTID:280677004 xref: TAO:0001029 xref: UMLS:C1512783 {source="ncithesaurus:Inner_Limiting_Membrane"} xref: Wikipedia:Inner_limiting_membrane xref: XAO:0003222 xref: ZFA:0001029 is_a: BFO:0000002 is_a: UBERON:0007619 {source="MA"} ! limiting membrane of retina relationship: BFO:0000051 CL:0000127 ! has part astrocyte relationship: BFO:0000051 GO:0043005 ! has part neuron projection relationship: RO:0002131 CL:0000636 ! overlaps Mueller cell relationship: RO:0002220 UBERON:0001797 ! adjacent to vitreous humor property_value: IAO:0000116 "TODO - check frog/fish" xsd:string [Term] id: UBERON:0001795 name: inner plexiform layer of retina def: "Cytoarchitectural layer of the retina that is made up of a dense reticulum of fibrils formed by interlaced dendrites of retinal ganglion cells and cells of the inner nuclear layer (adapted from Wikipedia)." [NLX:20558] subset: pheno_slim subset: vertebrate_core synonym: "inner plexiform layer" RELATED [BTO:0003175] synonym: "internal plexiform layer of retina" RELATED [NLXANAT:1005032] synonym: "IPL" NARROW OMO:0003000 [] synonym: "retina inner plexiform layer" EXACT [] synonym: "retina, inner plexiform layer" RELATED [BAMS:Ripl] synonym: "retinal inner plexiform layer" EXACT [] synonym: "retinal internal plexiform layer" RELATED [NLXANAT:1005032] synonym: "stratum plexifome internum" RELATED [BTO:0003175] synonym: "stratum plexiforme internum" EXACT [FMA:58704] synonym: "stratum plexiforme internum retinae" RELATED OMO:0003011 [Wikipedia:Inner_plexiform_layer] xref: BAMS:Ripl xref: BTO:0003175 xref: EMAPA:35741 xref: FMA:58704 xref: MA:0001312 xref: NCIT:C32809 xref: NLX:20558 xref: NLXANAT:1005032 xref: SCTID:280682006 xref: TAO:0001329 xref: UMLS:C0229221 {source="ncithesaurus:Inner_Plexiform_Layer"} xref: VHOG:0001168 xref: Wikipedia:Inner_plexiform_layer xref: XAO:0003225 xref: ZFA:0001329 is_a: UBERON:0001781 ! layer of retina intersection_of: UBERON:0001781 ! layer of retina intersection_of: RO:0002220 UBERON:0001791 ! adjacent to inner nuclear layer of retina intersection_of: RO:0002220 UBERON:0001792 ! adjacent to ganglionic layer of retina relationship: BFO:0000050 UBERON:0003902 ! part of retinal neural layer relationship: BFO:0000051 GO:0030425 ! has part dendrite relationship: RO:0002131 CL:0000740 ! overlaps retinal ganglion cell relationship: RO:0002131 CL:0000748 ! overlaps retinal bipolar neuron relationship: RO:0002220 UBERON:0001791 ! adjacent to inner nuclear layer of retina relationship: RO:0002220 UBERON:0001792 ! adjacent to ganglionic layer of retina relationship: RO:0002433 UBERON:0003902 ! contributes to morphology of retinal neural layer property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/5/55/Gray881.png" xsd:anyURI [Term] id: UBERON:0001796 name: aqueous humor of eyeball def: "A thick watery refractive medium that fills the space between the lens and the cornea[WP]." [Wikipedia:Aqueous_humor] subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "aqueous humor" EXACT [] synonym: "aqueous humour" EXACT [EHDAA2:0000139] synonym: "humor aquosus" EXACT OMO:0003011 [FMA:58819, FMA:TA] xref: EHDAA2:0000139 xref: EHDAA:10196 xref: EMAPA:18232 xref: ENVO:02000024 xref: FMA:58819 xref: GAID:890 xref: MA:0001236 xref: MESH:D001082 xref: NCIT:C13190 xref: SCTID:280587006 xref: UMLS:C0003662 {source="ncithesaurus:Aqueous_Humor"} xref: VHOG:0000548 xref: Wikipedia:Aqueous_humor xref: ZFA:0005564 is_a: UBERON:0006312 ! ocular refractive media is_a: UBERON:0006314 ! bodily fluid relationship: BFO:0000050 UBERON:0001766 ! part of anterior chamber of eyeball relationship: RO:0002433 UBERON:0001766 ! contributes to morphology of anterior chamber of eyeball property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/1/1e/Schematic_diagram_of_the_human_eye_en.svg" xsd:anyURI property_value: skos:prefLabel "aqueous humor of eyeball" xsd:string [Term] id: UBERON:0001797 name: vitreous humor def: "A transparent, semigelatinous substance that fills the cavity behind the crystalline lens of the eye and in front of the retina." [MP:0002699] subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "humor vitreous" EXACT [] synonym: "humor vitreus" EXACT OMO:0003011 [FMA:58822, FMA:TA] synonym: "humoral fluid" RELATED [BTO:0001451] synonym: "ocular fluid" RELATED [BTO:0001451] synonym: "portion of vitreous humor" BROAD [FMA:67388] synonym: "vitreous" EXACT [ZFA:0005561] synonym: "vitreous fluid" RELATED [BTO:0001451] synonym: "vitreous humour" RELATED [] synonym: "whole portion of vitreous humor" EXACT [FMA:58822] xref: BTO:0001451 xref: CALOHA:TS-0308 xref: EMAPA:17837 xref: ENVO:02000032 xref: EV:0100344 xref: FMA:58822 xref: MA:0001286 xref: MESH:D014822 {sssom:mapping_justification="https://w3id.org/semapv/vocab/LexicalMatching"} xref: NCIT:C13323 xref: UMLS:C0229096 {source="ncithesaurus:Vitreous_Humor"} xref: VHOG:0000795 xref: Wikipedia:Vitreous_humour xref: ZFA:0005561 is_a: UBERON:0006312 ! ocular refractive media relationship: BFO:0000050 UBERON:0001798 ! part of vitreous body relationship: RO:0000086 PATO:0000964 ! has quality transparent relationship: RO:0001025 UBERON:0005606 ! located in hyaloid cavity property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/1/1e/Schematic_diagram_of_the_human_eye_en.svg" xsd:anyURI [Term] id: UBERON:0001798 name: vitreous body def: "Gelatinous mucoid tissue that is composed of vitreous humor and fills the cavity behind the crystalline lens of the eye and in front of the retina[MP,modified]." [MP:0002699] subset: pheno_slim subset: uberon_slim xref: CALOHA:TS-0308 xref: FMA:58827 xref: GAID:919 xref: MA:0002462 xref: MESH:D014822 xref: NCIT:C33884 xref: SCTID:181170006 xref: UMLS:C0042905 {source="ncithesaurus:Vitreous_Body"} is_a: UBERON:0003566 ! head connective tissue is_a: UBERON:0011825 {source="FMA"} ! loose connective tissue relationship: BFO:0000050 UBERON:0001799 ! part of vitreous chamber of eyeball relationship: RO:0002254 UBERON:0002346 ! has developmental contribution from neurectoderm relationship: RO:0002473 UBERON:0001797 ! composed primarily of vitreous humor property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/1/1e/Schematic_diagram_of_the_human_eye_en.svg" xsd:anyURI property_value: IAO:0000116 "distinciton between body and humor requires more work. These may be merged in future. Note that FMA includes the hyaloid canal as part of the vitreous body" xsd:string [Term] id: UBERON:0001799 name: vitreous chamber of eyeball def: "The chamber in the eyeball enclosing the vitreous humor, bounded anteriorly by the lens and ciliary body and posteriorly by the posterior wall of the eyeball[BTO,modified]." [BTO:0002087] subset: uberon_slim synonym: "camera postrema" EXACT [FMA:58848] synonym: "camera postrema bulbi oculi" EXACT OMO:0003011 [FMA:58848, FMA:TA] synonym: "camera vitrea" EXACT [FMA:58848] synonym: "camera vitrea bulbi" EXACT [FMA:58848] synonym: "postremal chamber" EXACT [FMA:58848] synonym: "postremal chamber of eyeball" EXACT [FMA:58848] synonym: "vitreous chamber" EXACT [FMA:58848] xref: BTO:0002087 xref: EMAPA:37805 {source="MA:th"} xref: FMA:58848 xref: MA:0002461 xref: NCIT:C33885 xref: UMLS:C0229095 {source="ncithesaurus:Vitreous_Chamber"} xref: Wikipedia:Vitreous_chamber is_a: UBERON:0006311 ! chamber of eyeball intersection_of: UBERON:0006311 ! chamber of eyeball intersection_of: RO:0001015 UBERON:0001798 ! location of vitreous body relationship: BFO:0000050 UBERON:0001802 ! part of posterior segment of eyeball relationship: RO:0001015 UBERON:0001798 ! location of vitreous body [Term] id: UBERON:0001800 name: sensory ganglion def: "The clusters of neurons in the somatic peripheral nervous system which contain the cell bodies of sensory nerve axons, interneurons and non-neuronal supporting cells." [MP:0000960] subset: human_reference_atlas subset: pheno_slim synonym: "ganglion sensorium" EXACT OMO:0003011 [] xref: AEO:0001000 xref: BTO:0005630 xref: EMAPA:36596 xref: FMA:5885 xref: MA:0002566 xref: MESH:D017950 xref: NCIT:C13060 xref: UMLS:C0206429 {source="ncithesaurus:Sensory_Ganglion"} is_a: UBERON:0000045 ! ganglion intersection_of: UBERON:0000045 ! ganglion intersection_of: extends_fibers_into UBERON:0001027 ! sensory nerve relationship: extends_fibers_into UBERON:0001027 ! sensory nerve property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "sensory ganglion" xsd:string [Term] id: UBERON:0001801 name: anterior segment of eyeball def: "Any of the parts of the eye that lie in front of, or ventral to, the lens (inclusive)." [ISBN:0-683-40008-8, MESH:A09.371.060, MP:0005193] subset: pheno_slim subset: vertebrate_core synonym: "anterior eye segment" EXACT [] synonym: "anterior segment eye" EXACT [ZFA:0005566] synonym: "anterior segment of eye" EXACT [] synonym: "anterior segment of the eye" EXACT [] synonym: "eye anterior segment" EXACT [] synonym: "segmentum anterius (bulbus oculi)" EXACT [] synonym: "segmentum anterius bulbi oculi" RELATED OMO:0003011 [Wikipedia:Anterior_segment_of_eyeball] xref: EMAPA:36594 xref: FMA:58865 xref: MA:0002484 xref: MESH:D000869 xref: NCIT:C12668 xref: SCTID:280658001 xref: UMLS:C0003153 {source="ncithesaurus:Anterior_Eye_Segment"} xref: Wikipedia:Anterior_segment_of_eyeball xref: ZFA:0005566 is_a: UBERON:0000063 ! organ subunit disjoint_from: UBERON:0001802 {source="lexical"} ! posterior segment of eyeball relationship: BSPO:0000123 UBERON:0010230 {source="cjm"} ! eyeball of camera-type eye relationship: RO:0002433 UBERON:0000019 ! contributes to morphology of camera-type eye property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/b/ba/Cataract_in_human_eye.png" xsd:anyURI property_value: skos:prefLabel "anterior segment of eyeball" xsd:string [Term] id: UBERON:0001802 name: posterior segment of eyeball def: "Any of the parts of the eye that lie in back of, or dorsal to, the lens (but not inclusive)." [ISBN:0-683-40008-8, MP:0005195] subset: pheno_slim subset: vertebrate_core synonym: "eye posterior segment" EXACT [] synonym: "posterior eye segment" EXACT [] synonym: "posterior segment eye" EXACT [ZFA:0005567] synonym: "posterior segment of eye" EXACT [] synonym: "posterior segment of the eye" EXACT [] synonym: "segmentum posterius (bulbus oculi)" EXACT [] synonym: "segmentum posterius bulbi oculi" RELATED OMO:0003011 [Wikipedia:Posterior_segment_of_eyeball] xref: EMAPA:36595 xref: FMA:58868 xref: MA:0002485 xref: NCIT:C12906 xref: SCTID:280659009 xref: UMLS:C0278450 {source="ncithesaurus:Posterior_Eye_Segment"} xref: Wikipedia:Posterior_segment_of_eyeball xref: ZFA:0005567 is_a: UBERON:0000063 ! organ subunit relationship: BSPO:0000122 UBERON:0010230 {source="cjm"} ! eyeball of camera-type eye relationship: RO:0002433 UBERON:0000019 ! contributes to morphology of camera-type eye property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/1/1e/Schematic_diagram_of_the_human_eye_en.svg" xsd:anyURI property_value: skos:prefLabel "posterior segment of eyeball" xsd:string [Term] id: UBERON:0001803 name: epithelium of lens def: "A layer of epithelial cells that is part of the eye." [http://orcid.org/0000-0002-6601-2165] subset: human_reference_atlas subset: pheno_slim subset: vertebrate_core synonym: "epithelial tissue of eye lens" EXACT [OBOL:automatic] synonym: "epithelial tissue of lens" EXACT [OBOL:automatic] synonym: "epithelium lentis" EXACT OMO:0003011 [FMA:58871, FMA:TA] synonym: "epithelium of eye lens" EXACT [OBOL:automatic] synonym: "eye lens epithelial tissue" EXACT [OBOL:automatic] synonym: "eye lens epithelium" EXACT [OBOL:automatic] synonym: "lens epithelial tissue" EXACT [OBOL:automatic] synonym: "lens epithelium" EXACT [] xref: BTO:0001873 xref: CALOHA:TS-0543 xref: EMAPA:32871 xref: FMA:58871 xref: MA:0001301 xref: SCTID:362523006 xref: TAO:0001326 xref: Wikipedia:Lens_(anatomy)#Lens_Epithelium xref: XAO:0004094 xref: ZFA:0001326 is_a: UBERON:0000484 ! simple cuboidal epithelium is_a: UBERON:0015808 ! eye epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: BFO:0000050 UBERON:0000965 ! part of lens of camera-type eye relationship: BFO:0000050 UBERON:0000965 ! part of lens of camera-type eye relationship: RO:0002433 UBERON:0000965 ! contributes to morphology of lens of camera-type eye property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "epithelium of lens" xsd:string [Term] id: UBERON:0001804 name: capsule of lens def: "The elastic, clear, membrane-like structure, that is outer most layer of the lens." [MGI:smb, MP:0003236, PMID:15483628] subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "capsula lentis" EXACT OMO:0003011 [] synonym: "lens capsule" EXACT [] xref: EHDAA2:0000977 xref: EMAPA:18237 xref: FMA:58881 xref: MA:0001300 xref: NCIT:C32975 xref: SCTID:244500004 xref: UMLS:C0229232 {source="ncithesaurus:Lens_Capsule"} xref: VHOG:0000550 xref: Wikipedia:Lens_(anatomy)#Lens_capsule xref: ZFA:0005574 is_a: UBERON:0004121 ! ectoderm-derived structure is_a: UBERON:0005764 ! acellular membrane intersection_of: UBERON:0000476 ! acellular anatomical structure intersection_of: RO:0002007 UBERON:0000965 ! bounding layer of lens of camera-type eye relationship: BFO:0000051 CHEBI:35722 ! has part relationship: BFO:0000051 GO:0005587 ! has part collagen type IV trimer relationship: RO:0000086 PATO:0000964 ! has quality transparent relationship: RO:0002007 UBERON:0000965 ! bounding layer of lens of camera-type eye relationship: RO:0002202 UBERON:0005614 {source="EHDAA2"} ! develops from lens anterior epithelium property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/5/55/Gray883.png" xsd:anyURI property_value: skos:prefLabel "capsule of lens" xsd:string [Term] id: UBERON:0001805 name: autonomic ganglion def: "Ganglion that has dendrites that form a junction between autonomic nerves originating from the central nervous system and autonomic nerves innervating their target organs in the periphery. There are two subtypes, sympathetic ganglion and parasympathetic ganglion." [Wikipedia:Autonomic_ganglion] subset: human_reference_atlas subset: uberon_slim synonym: "autonomic nervous system ganglion" EXACT [OBOL:automatic] synonym: "ganglion autonomicum" RELATED OMO:0003011 [Wikipedia:Autonomic_ganglion] synonym: "ganglion of autonomic nervous system" EXACT [OBOL:automatic] synonym: "ganglion of visceral nervous system" EXACT [OBOL:automatic] synonym: "visceral nervous system ganglion" EXACT [OBOL:automatic] xref: AEO:0001001 xref: CALOHA:TS-2340 xref: EMAPA:18221 xref: FMA:5889 xref: MA:0000220 xref: MESH:D005725 xref: NCIT:C12720 xref: UMLS:C0017068 {source="ncithesaurus:Autonomic_Ganglion"} xref: Wikipedia:Autonomic_ganglion is_a: UBERON:0003338 ! ganglion of peripheral nervous system intersection_of: UBERON:0000045 ! ganglion intersection_of: BFO:0000050 UBERON:0002410 ! part of autonomic nervous system relationship: BFO:0000050 UBERON:0002410 ! part of autonomic nervous system relationship: extends_fibers_into UBERON:0034728 ! autonomic nerve property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/f/f7/Gray839.png" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "autonomic ganglion" xsd:string [Term] id: UBERON:0001806 name: sympathetic ganglion def: "A ganglion of the sympathetic nervous system. Examples: paravertebral and the prevertebral ganglia, which include the sympathetic chain ganglia, the superior, middle, and inferior cervical ganglia, and the aorticorenal, celiac, and stellate ganglia." [http://orcid.org/0000-0002-6601-2165, MP:0001008] subset: pheno_slim subset: uberon_slim synonym: "ganglion of sympathetic nervous system" EXACT [OBOL:automatic] synonym: "ganglion of sympathetic part of autonomic division of nervous system" EXACT [OBOL:automatic] synonym: "ganglion sympatheticum" EXACT [] synonym: "ganglion sympathicum" RELATED OMO:0003011 [BTO:0001333, Wikipedia:Sympathetic_ganglion] synonym: "sympathetic nervous system ganglion" EXACT [OBOL:automatic] synonym: "sympathetic part of autonomic division of nervous system ganglion" EXACT [OBOL:automatic] xref: AAO:0010773 xref: BTO:0001333 xref: CALOHA:TS-0994 xref: EHDAA2:0001969 xref: EMAPA:17157 xref: FMA:5890 xref: MA:0000226 xref: NCIT:C12467 xref: SCTID:362485003 xref: UMLS:C0017071 {source="ncithesaurus:Sympathetic_Ganglion"} xref: Wikipedia:Sympathetic_ganglion is_a: UBERON:0001805 ! autonomic ganglion intersection_of: UBERON:0000045 ! ganglion intersection_of: BFO:0000050 UBERON:0000013 ! part of sympathetic nervous system relationship: BFO:0000050 UBERON:0000013 ! part of sympathetic nervous system relationship: extends_fibers_into UBERON:0034729 ! sympathetic nerve relationship: RO:0002202 UBERON:0003083 {source="DOI:10.1101/gr.157586.113", source="ISBN:0073040584"} ! develops from trunk neural crest relationship: RO:0002433 UBERON:0000013 ! contributes to morphology of sympathetic nervous system property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/f/f7/Gray839.png" xsd:anyURI property_value: skos:prefLabel "sympathetic ganglion" xsd:string [Term] id: UBERON:0001807 name: paravertebral ganglion def: "Trunk ganglion which is part of a bilaterally paired set of sympathetic ganglia located anterior and lateral to the spinal cord." [Wikipedia:Paravertebral_ganglion, ZFIN:curator] subset: human_reference_atlas subset: uberon_slim subset: vertebrate_core synonym: "ganglia of sympathetic trunk" RELATED [Wikipedia:Paravertebral_ganglia] synonym: "ganglia trunci sympathici" RELATED OMO:0003011 [Wikipedia:Paravertebral_ganglia] synonym: "ganglion of sympathetic trunk" EXACT [] synonym: "ganglion trunci sympathetici" EXACT OMO:0003011 [] synonym: "ganglion trunci sympathici" EXACT OMO:0003011 [FMA:5891, FMA:TA] synonym: "paravertebral ganglia" RELATED OMO:0003004 [FMA:80128] synonym: "paravertebral ganglion" RELATED [Wikipedia:Paravertebral_ganglia] synonym: "sympathetic chain ganglia" RELATED OMO:0003004 [Wikipedia:Paravertebral_ganglia] synonym: "sympathetic chain ganglion" EXACT [] xref: EHDAA2:0001403 xref: EHDAA:5635 xref: FMA:5891 xref: MA:0003100 xref: SCTID:324478000 xref: TAO:0001556 xref: Wikipedia:Paravertebral_ganglion xref: ZFA:0001556 is_a: UBERON:0001806 ! sympathetic ganglion is_a: UBERON:0007134 {source="ZFA"} ! trunk ganglion intersection_of: UBERON:0000045 ! ganglion intersection_of: BFO:0000050 UBERON:0000407 ! part of sympathetic trunk relationship: BFO:0000050 UBERON:0000407 ! part of sympathetic trunk property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/2/2d/Gray847.png" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001808 name: parasympathetic ganglion def: "Ganglion containing neurons that receive innervation from parasympathetic neurons in the central nervous system and subserves parasympathetic functions through innervation of smooth muscle, cardiac muscle and glands." [NLXANAT:100303] subset: human_reference_atlas subset: pheno_slim subset: uberon_slim synonym: "ganglion parasympathicum" RELATED OMO:0003011 [BTO:0001256, Wikipedia:Parasympathetic_ganglion] xref: BTO:0001256 xref: EHDAA2:0001400 xref: EMAPA:32813 xref: FMA:5894 xref: MA:0002469 xref: NCIT:C52557 xref: NLXANAT:100303 xref: SCTID:279284004 xref: UMLS:C0017069 {source="ncithesaurus:Parasympathetic_Ganglion"} xref: Wikipedia:Parasympathetic_ganglion is_a: UBERON:0001805 ! autonomic ganglion is_a: UBERON:0010313 ! neural crest-derived structure intersection_of: UBERON:0001805 ! autonomic ganglion intersection_of: BFO:0000050 UBERON:0000011 ! part of parasympathetic nervous system relationship: BFO:0000050 UBERON:0000011 ! part of parasympathetic nervous system relationship: extends_fibers_into UBERON:0004293 ! parasympathetic nerve relationship: RO:0002433 UBERON:0000011 ! contributes to morphology of parasympathetic nervous system property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/f/f7/Gray839.png" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "parasympathetic ganglion" xsd:string [Term] id: UBERON:0001809 name: enteric ganglion subset: pheno_slim synonym: "intramural ganglion" EXACT [FMA:5896] xref: EMAPA:35312 xref: FMA:5896 xref: MA:0001144 xref: NCIT:C52709 xref: UMLS:C0501399 {source="ncithesaurus:Enteric_Ganglion"} xref: Wikipedia:Enteric_ganglia is_a: UBERON:0001808 {source="FMA"} ! parasympathetic ganglion intersection_of: UBERON:0001808 ! parasympathetic ganglion intersection_of: BFO:0000050 UBERON:0002005 ! part of enteric nervous system relationship: BFO:0000050 UBERON:0002005 ! part of enteric nervous system relationship: RO:0002433 UBERON:0002005 ! contributes to morphology of enteric nervous system [Term] id: UBERON:0001810 name: nerve plexus def: "Anatomical junction where subdivisions of two or more neural trees interconnect with one another to form a network through which nerve fibers of the constituent nerve trees become regrouped; together with other nerve plexuses, nerves and ganglia, it constitutes the peripheral nervous system. Examples: cervical nerve plexus, brachial nerve plexus, sacral nerve plexus[FMA]." [FMA:5901, https://github.com/obophenotype/cell-ontology/issues/1306, Wikipedia:Nervous_system_plexus] subset: human_reference_atlas subset: uberon_slim synonym: "plexus" BROAD [] xref: AEO:0000138 xref: BTO:0000205 xref: EHDAA2:0003138 xref: EHDAA:3780 xref: EMAPA:37683 {source="MA:th"} xref: FMA:5901 xref: MA:0002407 xref: NCIT:C12929 xref: SCTID:122455009 xref: UMLS:C0501403 {source="ncithesaurus:Nerve_Plexus"} xref: Wikipedia:Nervous_system_plexus is_a: UBERON:0007651 ! anatomical junction relationship: BFO:0000050 UBERON:0001016 ! part of nervous system relationship: BFO:0000051 CL:0000526 {source="AEO"} ! has part afferent neuron relationship: BFO:0000051 CL:0000527 {source="AEO"} ! has part efferent neuron property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001811 name: conjunctiva def: "The mucous membrane that lines the inner surface of the eyelids and the front of the eyeball." [MESH:A09.371.060.200, MGI:csmith, MP:0001310] subset: efo_slim subset: human_reference_atlas subset: pheno_slim subset: uberon_slim synonym: "conjunctivae" EXACT OMO:0003004 [XAO:0000182] synonym: "conjunctivas" EXACT OMO:0003004 [XAO:0000182] synonym: "tunica conjunctiva" EXACT OMO:0003011 [FMA:TA] synonym: "wall of conjunctival sac" EXACT [FMA:59011] xref: AAO:0010343 xref: BTO:0003415 xref: CALOHA:TS-2232 xref: EFO:0000374 xref: EV:0100340 xref: FMA:59011 xref: GAID:898 xref: MA:0000265 xref: MESH:D003228 xref: NCIT:C12341 xref: SCTID:181161008 xref: UMLS:C0009758 {source="ncithesaurus:Conjunctiva"} xref: Wikipedia:Conjunctiva xref: XAO:0000182 is_a: BFO:0000002 is_a: UBERON:0000060 {source="FMA"} ! anatomical wall relationship: BFO:0000050 UBERON:0005908 {source="cjm"} ! part of conjunctival sac relationship: BFO:0000050 UBERON:0010409 {source="MA"} ! part of ocular surface region relationship: RO:0002202 UBERON:0000076 {source="ISBN:0781772214"} ! develops from external ectoderm relationship: RO:0002220 UBERON:0001711 ! adjacent to eyelid relationship: RO:0002220 UBERON:0001773 ! adjacent to sclera relationship: RO:0002433 UBERON:0001801 ! contributes to morphology of anterior segment of eyeball property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/5/55/Gray883.png" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001813 name: spinal nerve plexus def: "An intermingling of fiber fascicles from adjacent spinal nerves to form a network." [http://www.medilexicon.com/medicaldictionary.php?t=70024] subset: human_reference_atlas synonym: "plexus nervorum spinalium" EXACT OMO:0003011 [FMA:5903, FMA:TA] synonym: "plexus of spinal nerves" EXACT [FMA:5903] synonym: "somatic nerve plexus" EXACT [FMA:5903] synonym: "spinal nerve plexus" EXACT [FMA:5903] xref: EHDAA2:0001899 xref: EMAPA:16987 xref: FMA:5903 xref: MA:0000235 xref: NCIT:C49601 xref: SCTID:42280003 xref: UMLS:C0228603 {source="ncithesaurus:Spinal_Nerve_Plexus"} xref: VHOG:0000925 is_a: UBERON:0001810 ! nerve plexus intersection_of: UBERON:0001810 ! nerve plexus intersection_of: extends_fibers_into UBERON:0001780 ! spinal nerve relationship: extends_fibers_into UBERON:0001780 ! spinal nerve property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001814 name: brachial nerve plexus def: "An arrangement of nerve fibers, running from the spine where it proceeds through the neck then the axilla and into the arm where it innervates skin and muscle. [WP,modified]." [UBERON:cjm, Wikipedia:Brachial_plexus] subset: human_reference_atlas subset: uberon_slim synonym: "brachial plexus" EXACT [MA:0001180] synonym: "plexus brachialis" RELATED OMO:0003011 [Wikipedia:Brachial_plexus] xref: EHDAA2:0000180 xref: EHDAA:3782 xref: EMAPA:16988 xref: FMA:5906 xref: GAID:842 xref: MA:0001180 xref: MESH:D001917 xref: NCIT:C12682 xref: SCTID:181002002 xref: UMLS:C0006090 {source="ncithesaurus:Brachial_Plexus"} xref: VHOG:0000372 xref: Wikipedia:Brachial_plexus is_a: UBERON:0000122 ! neuron projection bundle is_a: UBERON:0001813 ! spinal nerve plexus relationship: RO:0002134 UBERON:0002102 ! innervates forelimb property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/3/3a/Gray808.png" xsd:anyURI property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/c/c9/Brachial_plexus_color.svg" xsd:anyURI property_value: IAO:0000116 "check superclass - nerve vs collection of fibers vs junction; note that FMA also has 'brachial autonomic nerve plexus'" xsd:string property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001815 name: lumbosacral nerve plexus def: "An arrangement of nerve fibers, running from the spine that travels to the pelvic appendage where it innervates skin and muscle." [UBERON:cjm] subset: uberon_slim synonym: "lumbosacral plexus" EXACT [] synonym: "plexus lumbosacralis" EXACT OMO:0003011 [FMA:5907, FMA:TA] synonym: "plexus lumbosacralis" RELATED OMO:0003011 [Wikipedia:Lumbosacral_plexus] xref: BAMS:lsp xref: EHDAA2:0001040 xref: EHDAA:4673 xref: EMAPA:17587 xref: FMA:5907 xref: GAID:849 xref: MA:0001181 xref: MESH:D008160 xref: NCIT:C52805 xref: SCTID:181049003 xref: UMLS:C0024093 {source="ncithesaurus:Lumbosacral_Plexus"} xref: VHOG:0000926 xref: Wikipedia:Lumbosacral_plexus is_a: UBERON:0000122 ! neuron projection bundle is_a: UBERON:0001813 ! spinal nerve plexus relationship: RO:0002134 UBERON:0002103 ! innervates hindlimb property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/8/8d/Gray822.png" xsd:anyURI [Term] id: UBERON:0001816 name: autonomic nerve plexus def: "A nerve plexus that is part of an autonomic nervous system [Automatically generated definition]." [OBOL:automatic] synonym: "autonomic plexus" EXACT [] synonym: "plexus autonomicus" EXACT OMO:0003011 [FMA:5910, FMA:TA] synonym: "plexus nervosus visceralis" EXACT OMO:0003011 [FMA:5910, FMA:TA] synonym: "plexus visceralis" EXACT OMO:0003011 [FMA:5910, FMA:TA] synonym: "visceral nerve plexus" EXACT [] synonym: "visceral plexus" EXACT [] xref: EMAPA:18224 xref: FMA:5910 xref: MA:0000221 xref: SCTID:362482000 is_a: UBERON:0001810 ! nerve plexus intersection_of: UBERON:0001810 ! nerve plexus intersection_of: BFO:0000050 UBERON:0002410 ! part of autonomic nervous system relationship: BFO:0000050 UBERON:0002410 ! part of autonomic nervous system [Term] id: UBERON:0001817 name: lacrimal gland def: "The lacrimal glands are paired almond-shaped glands, located in or near the orbital region, that secrete the aqueous layer of the tear film.[WP]." [http://orcid.org/0000-0002-6601-2165, Wikipedia:Lacrimal_gland] subset: efo_slim subset: organ_slim subset: pheno_slim subset: uberon_slim synonym: "glandula lacrimalis" EXACT OMO:0003011 [Wikipedia:Lacrimal_gland] synonym: "glandula praeorbitalis" RELATED SENSU [NCBITaxon:91561, Wikipedia:Preorbital_gland] synonym: "lacrimal-preorbital gland" EXACT [http://orcid.org/0000-0002-6601-2165] synonym: "preorbital gland" RELATED SENSU [NCBITaxon:91561, Wikipedia:Preorbital_gland] synonym: "tear gland" RELATED [BTO:0000044] xref: BTO:0000044 xref: CALOHA:TS-0512 xref: EFO:0001389 xref: EMAPA:35463 xref: EV:0100339 xref: FMA:59101 xref: MA:0001296 xref: NCIT:C12346 xref: SCTID:181147003 xref: UMLS:C0022907 {source="ncithesaurus:Lacrimal_Gland"} xref: VHOG:0001476 xref: Wikipedia:Lacrimal_gland xref: Wikipedia:Preorbital_gland is_a: BFO:0000002 is_a: UBERON:0002365 ! exocrine gland is_a: UBERON:0004859 ! eye gland is_a: UBERON:0015154 ! lateral gland of orbital region intersection_of: UBERON:0002530 ! gland intersection_of: BFO:0000050 UBERON:0001750 ! part of lacrimal apparatus relationship: BFO:0000050 UBERON:0001750 ! part of lacrimal apparatus relationship: RO:0002202 UBERON:0022284 ! develops from lacrimal gland bud relationship: RO:0002433 UBERON:0001750 ! contributes to morphology of lacrimal apparatus property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/c/cf/Gray896.png" xsd:anyURI property_value: RO:0002161 NCBITaxon:8570 {source="PMID:7559104"} [Term] id: UBERON:0001820 name: sweat gland def: "Any of the coil glands of the skin that secrete sweat." [ISBN:0-683-40008-8, MP:0000674] subset: human_reference_atlas subset: organ_slim subset: pheno_slim subset: uberon_slim synonym: "glandula sudorifera" RELATED [BTO:0001331] synonym: "sudoriferous gland" RELATED [BTO:0001331] synonym: "sudoriparous gland" RELATED [BTO:0001331] xref: BTO:0001331 xref: CALOHA:TS-0993 xref: EMAPA:35844 xref: EV:0100160 xref: FMA:59152 xref: GAID:943 xref: MA:0000150 xref: MESH:D013545 xref: NCIT:C33712 xref: SCTID:361700009 xref: UMLS:C0038989 {source="ncithesaurus:Sweat_Gland"} xref: VHOG:0001467 xref: Wikipedia:Sweat_gland is_a: BFO:0000002 is_a: UBERON:0007771 ! epidermis gland is_a: UBERON:0019319 ! exocrine gland of integumental system intersection_of: UBERON:0002530 ! gland intersection_of: RO:0003000 UBERON:0001089 ! produces sweat relationship: RO:0000086 PATO:0002299 ! has quality tubular relationship: RO:0002202 UBERON:0005089 {evidence="definitional"} ! develops from sweat gland placode relationship: RO:0003000 UBERON:0001089 ! produces sweat property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/6/6d/Skin.svg" xsd:anyURI property_value: IAO:0000116 "TODO - check if all sweat glands are epidermal - see EMAPA:29743" xsd:string property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001821 name: sebaceous gland def: "A holocrine gland that secretes sebum into the hair follicles, or in hairless areas into ducts.[MP]." [MP:0000647, Wikipedia:Sebaceous_gland] subset: human_reference_atlas subset: organ_slim subset: pheno_slim subset: uberon_slim synonym: "glandula sebacea" RELATED OMO:0003011 [Wikipedia:Sebaceous_gland] synonym: "glandula sebaceae" RELATED [BTO:0001980] synonym: "sebaceous follicle" RELATED [BTO:0001980] xref: BTO:0001980 xref: CALOHA:TS-2384 xref: EMAPA:35754 xref: EV:0100161 xref: FMA:59160 xref: GAID:900 xref: MA:0002565 xref: MESH:D012627 xref: NCIT:C33519 xref: SCTID:361697005 xref: UMLS:C0036505 {source="ncithesaurus:Sebaceous_Gland"} xref: VHOG:0001468 xref: Wikipedia:Sebaceous_gland is_a: BFO:0000002 is_a: UBERON:0007771 ! epidermis gland is_a: UBERON:0012344 {source="Wikipedia"} ! holocrine gland is_a: UBERON:0019319 ! exocrine gland of integumental system relationship: BFO:0000050 UBERON:0011932 ! part of pilosebaceous unit relationship: RO:0002202 UBERON:0005088 {evidence="definitional"} ! develops from sebaceous gland placode relationship: RO:0003000 UBERON:0001866 ! produces sebum property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/4/49/HairFollicle.png" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001823 name: nasal cartilage def: "One of the cartilage structures in the nose that provide form and support[WP]." [Wikipedia:Nasal_cartilage] subset: pheno_slim subset: uberon_slim synonym: "cartilage of nose" EXACT [] xref: CALOHA:TS-0655 xref: EMAPA:37681 {source="MA:th"} xref: FMA:59502 xref: MA:0001883 xref: NCIT:C49593 xref: SCTID:278941001 xref: UMLS:C0225415 {source="ncithesaurus:Nasal_Cartilage"} xref: Wikipedia:Nasal_cartilage is_a: UBERON:0002418 {source="MA"} ! cartilage tissue is_a: UBERON:0003566 ! head connective tissue is_a: UBERON:0007844 ! cartilage element intersection_of: UBERON:0007844 ! cartilage element intersection_of: BFO:0000050 UBERON:0000004 ! part of nose relationship: BFO:0000050 UBERON:0000004 ! part of nose relationship: RO:0001015 UBERON:0000402 ! location of nasal vestibule property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/e/e1/Gray852.png" xsd:anyURI [Term] id: UBERON:0001824 name: mucosa of larynx def: "The mucous lining of the larynx, which is composed of squamous epithelium in the upper larynx and ciliated columnar epithelium in the lower larynx." [MP:0002261] synonym: "laryngeal mucosa" EXACT [] synonym: "laryngeal mucous membrane" RELATED [EMAPA:18334] synonym: "larynx mucosa" EXACT [] synonym: "larynx mucosa of organ" EXACT [OBOL:automatic] synonym: "larynx mucous membrane" EXACT [OBOL:automatic] synonym: "larynx organ mucosa" EXACT [OBOL:automatic] synonym: "mucosa of organ of larynx" EXACT [OBOL:automatic] synonym: "mucous membrane of larynx" EXACT [] synonym: "organ mucosa of larynx" EXACT [OBOL:automatic] synonym: "tunica mucosa laryngis" EXACT OMO:0003011 [FMA:59662, FMA:TA] xref: EMAPA:18334 xref: FMA:59662 xref: GAID:301 xref: MA:0001766 xref: MESH:D007820 xref: NCIT:C49246 xref: SCTID:361940006 xref: UMLS:C0023053 {source="ncithesaurus:Laryngeal_Mucosa"} is_a: UBERON:0004785 ! respiratory system mucosa intersection_of: UBERON:0000344 ! mucosa intersection_of: BFO:0000050 UBERON:0001737 ! part of larynx relationship: BFO:0000050 UBERON:0001737 ! part of larynx property_value: skos:prefLabel "mucosa of larynx" xsd:string [Term] id: UBERON:0001826 name: nasal cavity mucosa def: "The mucous membrane that lines the nasal cavity[MP]." [MP:0002238] subset: pheno_slim synonym: "mucosa of nose" EXACT [FMA:59684] synonym: "mucous membrane of nose" EXACT [FMA:59684] synonym: "nasal mucosa" RELATED [] synonym: "tunica mucosa nasalis" EXACT [] synonym: "tunica mucosa nasi" EXACT OMO:0003011 [FMA:59684, FMA:TA] xref: BTO:0000912 xref: CALOHA:TS-0657 xref: EMAPA:36026 xref: FMA:59684 xref: GAID:302 xref: SCTID:310211009 xref: Wikipedia:Mucous_membrane_of_nose is_a: UBERON:0004785 ! respiratory system mucosa intersection_of: UBERON:0000344 ! mucosa intersection_of: BFO:0000050 UBERON:0015788 ! part of olfactory apparatus chamber relationship: RO:0002007 UBERON:0015788 ! bounding layer of olfactory apparatus chamber property_value: IAO:0000116 "TODO - check lining vs part of. split olfactory and nasal mucosa?" xsd:string property_value: skos:prefLabel "nasal cavity mucosa" xsd:string [Term] id: UBERON:0001827 name: secretion of lacrimal gland def: "Aqueous substance secreted by the lacrimal gland." [http://orcid.org/0000-0002-6601-2165, Wikipedia:Tear] subset: uberon_slim synonym: "lacrimal fluid" EXACT [] synonym: "lacrimal gland secretion" EXACT [] synonym: "lacrimal secretion" EXACT [] synonym: "tear" EXACT [FMA:59756] synonym: "tear fluid" RELATED [BTO:0001499] synonym: "tears" EXACT OMO:0003004 [] xref: BTO:0001499 xref: CALOHA:TS-1016 xref: EMAPA:36537 xref: ENVO:02000034 xref: FMA:59756 xref: GAID:1173 xref: galen:Tear xref: galen:Tears xref: MA:0002508 xref: MESH:D013666 xref: NCIT:C33739 xref: UMLS:C0039409 {source="ncithesaurus:Tear"} xref: Wikipedia:Tear is_a: UBERON:0000456 ! secretion of exocrine gland intersection_of: UBERON:0000456 ! secretion of exocrine gland intersection_of: RO:0003001 UBERON:0001817 ! produced by lacrimal gland relationship: BFO:0000051 PR:000009978 ! has part lactotransferrin relationship: RO:0003001 UBERON:0001817 ! produced by lacrimal gland [Term] id: UBERON:0001828 name: gingiva def: "The fibrous investing tissue, covered by keratinized epithelium, that immediately surrounds a tooth and is contiguous with its periodontal ligament and with the mucosal tissues of the mouth[Glossary of Periodontal Terms 2001]." [ISBN:0013002015, Wikipedia:Gingiva] subset: efo_slim subset: human_reference_atlas subset: pheno_slim subset: uberon_slim synonym: "gingival mucosa" RELATED [] synonym: "gum" EXACT [FMA:59762] synonym: "gum tissue" EXACT [https://orcid.org/0000-0002-6601-2165] synonym: "gums" EXACT [] xref: BTO:0000519 xref: CALOHA:TS-2074 xref: EFO:0001925 xref: EMAPA:35945 xref: EV:0100064 xref: FMA:59762 xref: GAID:1257 xref: galen:Gingiva xref: MA:0000342 xref: MESH:D005881 xref: NCIT:C32677 xref: SCTID:181224006 xref: UMLS:C0017562 {source="ncithesaurus:Gingiva"} xref: VHOG:0001269 xref: Wikipedia:Gingiva is_a: UBERON:0003729 ! mouth mucosa relationship: BFO:0000050 UBERON:0003729 {source="Carranza"} ! part of mouth mucosa relationship: BFO:0000050 UBERON:0011595 ! part of jaw region relationship: RO:0002150 UBERON:0003729 {source="ISBN:0013002015"} ! continuous with mouth mucosa relationship: RO:0002220 UBERON:0004103 ! adjacent to alveolar ridge relationship: RO:0002220 UBERON:0008266 ! adjacent to periodontal ligament property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/mouth-female/v1.0/assets/3d-vh-f-mouth.glb" xsd:anyURI property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/mouth-male/v1.0/assets/3d-vh-m-mouth.glb" xsd:anyURI property_value: foaf:depiction "https://upload.wikimedia.org/wikipedia/commons/2/2e/Tooth_Section.svg" xsd:anyURI property_value: IAO:0000116 "FMA has a 3-level breakdown of jaws into: region, jaw (skeleton+gums), skeleton." xsd:string property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001829 name: major salivary gland def: "One of the three largest glands of the oral cavity that secrete most of the saliva, including the parotid, submandibular, and sublingual glands." [MP:0003792] subset: human_reference_atlas subset: organ_slim subset: pheno_slim xref: FMA:59788 xref: galen:MajorSalivaryGland xref: MA:0002478 xref: NCIT:C12999 xref: SCTID:303049006 xref: UMLS:C0930553 {source="ncithesaurus:Major_Salivary_Gland"} is_a: UBERON:0001044 ! saliva-secreting gland is_a: UBERON:0015212 ! lateral structure relationship: BSPO:0000126 UBERON:0000165 ! mouth property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/mouth-female/v1.0/assets/3d-vh-f-mouth.glb" xsd:anyURI property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/mouth-male/v1.0/assets/3d-vh-m-mouth.glb" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001831 name: parotid gland def: "The parotid gland is the largest of the salivary glands. It is found wrapped around the mandibular ramus, and it secretes saliva through Stensen's duct into the oral cavity, to facilitate mastication and swallowing. [WP,unvetted]." [Wikipedia:Parotid_gland] comment: The mouse parotid, exorbital lacrimal gland and exocrine pancreas have similar histological appearances[ISBN:0123813611] subset: efo_slim subset: human_reference_atlas subset: pheno_slim subset: uberon_slim synonym: "glandula parotidea" RELATED OMO:0003011 [Wikipedia:Parotid_gland] synonym: "parotid" EXACT [] xref: AAO:0010095 xref: BTO:0001004 xref: CALOHA:TS-0748 xref: EFO:0002558 xref: EMAPA:18537 xref: EV:0100060 xref: FMA:59790 xref: GAID:938 xref: galen:ParotidGland xref: MA:0001585 xref: MESH:D010306 xref: NCIT:C12427 xref: SCTID:181234002 xref: UMLS:C0030580 {source="ncithesaurus:Parotid_Gland"} xref: VHOG:0000308 xref: Wikipedia:Parotid_gland is_a: BFO:0000002 is_a: UBERON:0000409 ! serous gland is_a: UBERON:0001829 ! major salivary gland is_a: UBERON:0012102 ! buccal salivary gland relationship: BSPO:0000126 UBERON:0001710 {source="FMA-abduced-lr"} ! lower jaw region relationship: RO:0002202 UBERON:0008801 ! develops from parotid gland primordium property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/5/51/Illu_quiz_hn_02.jpg" xsd:anyURI property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/mouth-female/v1.0/assets/3d-vh-f-mouth.glb" xsd:anyURI property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/mouth-male/v1.0/assets/3d-vh-m-mouth.glb" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001832 name: sublingual gland def: "The small mucin-producing salivary glands in the floor of the mouth beneath the tongue, anterior to the submandibular gland." [MGI:hdene, MP:0004035] subset: human_reference_atlas subset: pheno_slim subset: uberon_slim synonym: "ductus sublingualis" EXACT [] synonym: "glandula sublingualis" RELATED OMO:0003011 [Wikipedia:Sublingual_gland] synonym: "Rivinus gland" RELATED [BTO:0001315] synonym: "Rivinus' gland" EXACT [] synonym: "sublingual salivary gland" RELATED [] synonym: "submaxillary gland" RELATED [MA:0001589] xref: BTO:0001315 xref: CALOHA:TS-0987 xref: EMAPA:18809 xref: EV:0100062 xref: FMA:59791 xref: GAID:941 xref: MA:0001588 xref: MESH:D013361 xref: NCIT:C12234 xref: SCTID:362176005 xref: UMLS:C0038553 {source="ncithesaurus:Sublingual_Salivary_Gland"} xref: VHOG:0000363 xref: Wikipedia:Sublingual_gland is_a: BFO:0000002 is_a: UBERON:0001829 {source="FMA"} ! major salivary gland relationship: RO:0002202 UBERON:0006297 ! develops from sublingual gland primordium property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/7/7d/Gray1024.png" xsd:anyURI property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/mouth-female/v1.0/assets/3d-vh-f-mouth.glb" xsd:anyURI property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/mouth-male/v1.0/assets/3d-vh-m-mouth.glb" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001833 name: lip def: "One of the two fleshy folds which surround the opening of the mouth." [http://www.medterms.com/script/main/art.asp?articlekey=9458, Wikipedia:Lip] subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "labia oris" RELATED OMO:0003011 [Wikipedia:Lip] synonym: "lips" RELATED [] xref: BTO:0001647 xref: CALOHA:TS-0558 xref: EMAPA:32839 xref: FMA:59816 xref: GAID:76 xref: galen:Lip xref: MA:0000343 xref: MESH:D008046 xref: NCIT:C12220 xref: SCTID:181221003 xref: TAO:0007006 xref: UMLS:C0023759 {source="ncithesaurus:Lip"} xref: VHOG:0000677 xref: Wikipedia:Lip xref: ZFA:0007006 is_a: UBERON:0003102 {source="ZFA"} ! surface structure relationship: BFO:0000050 UBERON:0000165 {source="BTO", source="FMA-implicit", source="VHOG", source="ZFA"} ! part of mouth relationship: BFO:0000050 UBERON:0001456 ! part of face relationship: RO:0002221 UBERON:0000166 {source="cjm"} ! surrounds oral opening relationship: RO:0002433 UBERON:0000165 ! contributes to morphology of mouth property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/9/90/Lips.JPG" xsd:anyURI property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/9/99/Mouth.jpg" xsd:anyURI property_value: RO:0002161 NCBITaxon:8782 property_value: skos:prefLabel "lip" xsd:string [Term] id: UBERON:0001834 name: upper lip def: "Lip that covers the upper portion of the mouth.[TAO]." [TAO:0001970, Wikipedia:Upper_lip] subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "labium superius oris" RELATED OMO:0003011 [Wikipedia:Upper_lip] synonym: "upper jaw lip" EXACT [https://orcid.org/0000-0002-6601-2165] xref: EMAPA:17925 xref: FMA:59817 xref: MA:0000919 xref: SCTID:245776003 xref: TAO:0001970 xref: VHOG:0001750 xref: Wikipedia:Upper_lip xref: ZFA:0005226 is_a: BFO:0000002 is_a: UBERON:0001833 ! lip intersection_of: UBERON:0001833 ! lip intersection_of: BFO:0000050 UBERON:0001709 ! part of upper jaw region relationship: BFO:0000050 UBERON:0001709 ! part of upper jaw region relationship: RO:0002495 UBERON:0011592 ! immediate transformation of future upper lip property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/d/d4/Illu01_head_neck.jpg" xsd:anyURI property_value: skos:prefLabel "upper lip" xsd:string [Term] id: UBERON:0001835 name: lower lip def: "Lip that covers the lower portion of the mouth.[TAO]." [TAO:0002060, Wikipedia:Lower_lip] subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "labium inferius oris" RELATED OMO:0003011 [Wikipedia:Lower_lip] synonym: "lower jaw lip" EXACT [https://orcid.org/0000-0002-6601-2165] xref: EMAPA:17909 xref: FMA:59818 xref: MA:0000921 xref: NCIT:C94572 xref: SCTID:245777007 xref: TAO:0002060 xref: UMLS:C0458583 {source="ncithesaurus:Lower_Lip"} xref: Wikipedia:Lower_lip xref: ZFA:0005225 is_a: BFO:0000002 is_a: UBERON:0001833 ! lip intersection_of: UBERON:0001833 ! lip intersection_of: BFO:0000050 UBERON:0001710 ! part of lower jaw region relationship: BFO:0000050 UBERON:0001710 ! part of lower jaw region relationship: RO:0002202 UBERON:0011596 ! develops from future lower lip property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/9/99/Mouth.jpg" xsd:anyURI property_value: skos:prefLabel "lower lip" xsd:string [Term] id: UBERON:0001836 name: saliva def: "A fluid produced in the oral cavity by salivary glands, typically used in predigestion, but also in other functions." [GO:0046541, Wikipedia:Saliva] subset: uberon_slim synonym: "sailva normalis" RELATED OMO:0003011 [Wikipedia:Saliva] synonym: "saliva atomaris" RELATED OMO:0003011 [Wikipedia:Saliva] synonym: "saliva molecularis" RELATED OMO:0003011 [Wikipedia:Saliva] synonym: "salivary gland secretion" EXACT [FMA:59862] xref: BTO:0001202 xref: CALOHA:TS-0891 xref: EMAPA:36536 xref: ENVO:02000036 xref: FMA:59862 xref: GAID:1167 xref: galen:Saliva xref: MA:0002507 xref: MAT:0000444 xref: MESH:D012463 xref: NCIT:C13275 xref: UMLS:C0036087 {source="ncithesaurus:Saliva"} xref: Wikipedia:Saliva is_a: UBERON:0000456 ! secretion of exocrine gland relationship: RO:0002216 GO:0007586 ! capable of part of digestion [Term] id: UBERON:0001837 name: duct of salivary gland def: "The duct of a salivary gland." [http://orcid.org/0000-0002-6601-2165] subset: pheno_slim subset: uberon_slim synonym: "salivary duct" EXACT [] synonym: "salivary gland duct" EXACT [] synonym: "secretory duct" RELATED [BTO:0005115] xref: BTO:0005115 xref: EMAPA:35750 xref: FMA:59908 xref: GAID:939 xref: MA:0001586 xref: MESH:D018987 xref: NCIT:C32486 xref: SCTID:181238004 xref: Wikipedia:Salivary_duct is_a: UBERON:0000025 ! tube is_a: UBERON:0003928 ! digestive system duct intersection_of: UBERON:0000058 ! duct intersection_of: BFO:0000050 UBERON:0001044 ! part of saliva-secreting gland relationship: BFO:0000050 UBERON:0001044 ! part of saliva-secreting gland relationship: channel_for UBERON:0001836 ! saliva relationship: channels_from UBERON:0001044 ! saliva-secreting gland relationship: channels_into UBERON:0000165 ! mouth relationship: RO:0002433 UBERON:0001044 ! contributes to morphology of saliva-secreting gland [Term] id: UBERON:0001838 name: sublingual duct def: "A duct of a sublingual gland." [http://orcid.org/0000-0002-6601-2165] subset: human_reference_atlas subset: pheno_slim subset: uberon_slim xref: BTO:0004558 xref: EMAPA:36564 xref: FMA:59983 xref: MA:0002699 xref: SCTID:281000009 xref: Wikipedia:Sublingual_duct is_a: UBERON:0001837 ! duct of salivary gland intersection_of: UBERON:0001837 ! duct of salivary gland intersection_of: BFO:0000050 UBERON:0001832 ! part of sublingual gland relationship: BFO:0000050 UBERON:0001832 ! part of sublingual gland relationship: channels_from UBERON:0001832 ! sublingual gland relationship: RO:0002433 UBERON:0001832 ! contributes to morphology of sublingual gland property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001839 name: bony labyrinth def: "A system of fluid passages in the inner ear, including both the cochlea, which is part of the auditory system, and the vestibular system, which provides the sense of balance. The bony labyrinth, or osseous labyrinth, is the network of passages with bony walls lined with periosteum. The bony labyrinth is lined with the membranous labyrinth. There is a layer of perilymph between them. The three parts of the bony labyrinth are the vestibule of the ear, the semicircular canals, and the cochlea. The vestibular system is the region of the inner ear where the semicircular canals converge, close to the cochlea (the hearing organ). The vestibular system works with the visual system to keep objects in focus when the head is moving. Joint and muscle receptors also are important in maintaining balance. The brain receives, interprets, and processes the information from these systems that control our balance. [WP,unvetted]." [Wikipedia:Bony_labyrinth] comment: Ideally we would place a spatially disjoint from relationship to membranous labyrinth, but there are many parts in common. this should be resolved. subset: pheno_slim subset: uberon_slim synonym: "labyrinthus osseus" RELATED OMO:0003011 [Wikipedia:Bony_labyrinth] synonym: "osseous labyrinth" EXACT [] synonym: "osseus labyrinth" RELATED [] xref: AAO:0011078 xref: BTO:0004685 xref: CALOHA:TS-2080 xref: EMAPA:36580 xref: EV:0100362 xref: FMA:60179 xref: MA:0000238 xref: NCIT:C33227 xref: SCTID:279727008 xref: UMLS:C0458699 {source="ncithesaurus:Osseous_Labyrinth"} xref: VHOG:0001219 xref: Wikipedia:Bony_labyrinth xref: XAO:0000193 is_a: UBERON:0034921 ! multi organ part structure relationship: BFO:0000050 UBERON:0001694 {source="FMA", source="MA"} ! part of petrous part of temporal bone relationship: BFO:0000050 UBERON:0001846 {source="FMA"} ! part of internal ear relationship: BFO:0000050 UBERON:0004681 ! part of vestibular system property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/2/22/Gray920.png" xsd:anyURI property_value: skos:prefLabel "bony labyrinth" xsd:string [Term] id: UBERON:0001840 name: semicircular canal def: "One of three half-circular, interconnected tubes located inside each ear[WP]." [Wikipedia:Semicircular_canal] subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "canalis semicircularis" RELATED OMO:0003011 [Wikipedia:Semicircular_canal] synonym: "ductus semicirculares" RELATED OMO:0003004 [BTO:0003383, FMA:71880, FMA:TA] synonym: "scc" RELATED [TAO:0000431] synonym: "semicircular canals" EXACT OMO:0003004 [TAO:0000431] synonym: "semicircular ducts" RELATED OMO:0003004 [XAO:0000198] xref: AAO:0011098 xref: BTO:0003383 xref: CALOHA:TS-2164 xref: EMAPA:32832 xref: EV:0100365 xref: FMA:60186 xref: GAID:776 xref: MA:0000249 xref: MESH:D012665 xref: NCIT:C33527 xref: SCTID:279757004 xref: TAO:0000431 xref: UMLS:C0036622 {source="ncithesaurus:Semicircular_Canal"} xref: VHOG:0001144 xref: Wikipedia:Semicircular_canal xref: XAO:0000198 xref: ZFA:0000431 is_a: BFO:0000002 is_a: UBERON:0000025 {source="GO"} ! tube relationship: BFO:0000050 UBERON:0001849 {source="OG"} ! part of membranous labyrinth relationship: RO:0002202 UBERON:0003051 ! develops from ear vesicle property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/3/33/Balance_Disorder_Illustration_A.png" xsd:anyURI property_value: skos:prefLabel "semicircular canal" xsd:string [Term] id: UBERON:0001844 name: cochlea def: "The spiral-shaped bony canal in the inner ear containing the hair cells that transduce sound. Its core component is the Organ of Corti, the sensory organ of hearing, which is distributed along the partition separating fluid chambers in the coiled tapered tube of the cochlea. [WP,modified]." [ISBN:0-683-40008-8, MP:0000031, Wikipedia:Cochlea] subset: efo_slim subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "cochleae" RELATED OMO:0003004 [] synonym: "cochlear duct" RELATED [] synonym: "cochlear organ" RELATED [BTO:0000267] synonym: "cochlear part of bony labyrinth" EXACT [] synonym: "lagena" EXACT SENSU [XAO:0000197] synonym: "lagenas" RELATED OMO:0003004 [ZFA:0000374] xref: AAO:0000253 xref: BIRNLEX:1190 xref: BTO:0000267 xref: CALOHA:TS-0151 xref: EFO:0000357 xref: EMAPA:17597 xref: EV:0100363 xref: FMA:60201 xref: GAID:724 xref: MA:0000240 xref: MAT:0000144 xref: MESH:D003051 xref: MIAA:0000144 xref: NCIT:C12395 xref: NIFSTD_RETIRED:birnlex_883 xref: SCTID:181187008 xref: TAO:0000374 xref: UMLS:C0009195 {source="ncithesaurus:Cochlea", source="BIRNLEX:1190"} xref: UMLS:C1278895 {source="BIRNLEX:1190"} xref: VHOG:0000691 xref: Wikipedia:Cochlea xref: XAO:0000197 xref: ZFA:0000374 is_a: UBERON:0034921 ! multi organ part structure relationship: BFO:0000050 UBERON:0001839 {source="FMA", source="VHOG", source="XAO", source="ncit"} ! part of bony labyrinth relationship: RO:0002433 UBERON:0001846 ! contributes to morphology of internal ear property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/c/c7/Cochlea-crosssection.png" xsd:anyURI property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/c/cb/Cochlea-crosssection.svg" xsd:anyURI property_value: skos:prefLabel "cochlea" xsd:string [Term] id: UBERON:0001845 name: perilymph def: "Transudate contained in the osseous labyrinth outside the membranous labyrinth.[FMA]." [FMA:FMA, Wikipedia:Perilymph] subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "liquor cotunnii" RELATED OMO:0003011 [Wikipedia:Perilymph] synonym: "perilympha" RELATED [Wikipedia:Perilymph] xref: EMAPA:36549 xref: FMA:60908 xref: GAID:1185 xref: MA:0002529 xref: MESH:D010498 xref: NCIT:C33297 xref: TAO:0005413 xref: UMLS:C0031059 {source="ncithesaurus:Perilymph"} xref: Wikipedia:Perilymph xref: ZFA:0005413 is_a: UBERON:0006586 ! otolymph relationship: RO:0001025 UBERON:0002278 ! located in perilymphatic space relationship: RO:0002221 UBERON:0001849 {source="Wikipedia"} ! surrounds membranous labyrinth [Term] id: UBERON:0001846 name: internal ear def: "Complex labyrinthine structure that comprises sensory endorgans specialized for vestibular, auditory, and acoustico-vestibular sensation." [PMID:16217737, Wikipedia:Internal_ear, ZFIN:curator] subset: efo_slim subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "auris interna" RELATED [BTO:0000630] synonym: "inner ear" EXACT [] synonym: "labyrinth" RELATED [] synonym: "otocyst" RELATED [] xref: AAO:0000238 xref: BIRNLEX:1196 xref: BTO:0000630 xref: CALOHA:TS-0478 xref: EFO:0001363 xref: EHDAA2:0000831 xref: EHDAA:504 xref: EMAPA:16194 xref: EV:0100361 xref: FMA:60909 xref: GAID:871 xref: galen:InnerEar xref: MA:0000237 xref: MAT:0000145 xref: MESH:D007758 xref: MIAA:0000145 xref: NCIT:C12499 xref: SCTID:181189006 xref: SCTID:304982002 xref: TAO:0000217 xref: UMLS:C0022889 {source="ncithesaurus:Internal_Ear", source="BIRNLEX:1196"} xref: UMLS:C1268973 {source="BIRNLEX:1196"} xref: VHOG:0000284 xref: Wikipedia:Internal_ear xref: XAO:0000192 xref: ZFA:0000217 is_a: BFO:0000002 is_a: UBERON:0034921 ! multi organ part structure relationship: BFO:0000050 UBERON:0001690 ! part of ear relationship: RO:0002202 UBERON:0003051 {evidence="definitional"} ! develops from ear vesicle property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/1/19/Gray923.png" xsd:anyURI property_value: skos:prefLabel "internal ear" xsd:string [Term] id: UBERON:0001848 name: auricular cartilage def: "Cartilage of the pinna and much of the external ear canal." [http://medical-dictionary.thefreedictionary.com/auricular+cartilage] subset: pheno_slim synonym: "cartilage of pinna" EXACT [FMA:61013] synonym: "pinna cartilage" EXACT [] xref: EMAPA:35158 xref: FMA:61013 xref: MA:0001227 xref: SCTID:279627003 is_a: UBERON:0034944 ! zone of organ intersection_of: UBERON:0034944 ! zone of organ intersection_of: BFO:0000050 UBERON:0001757 ! part of pinna intersection_of: BFO:0000050 UBERON:0001867 ! part of cartilage of external ear relationship: BFO:0000050 UBERON:0001757 ! part of pinna relationship: BFO:0000050 UBERON:0001867 ! part of cartilage of external ear [Term] id: UBERON:0001849 name: membranous labyrinth def: "Organ with organ cavity which consists of the vestibular labyrinth and the cochlear labyrinth. The membranous labyrinth is lodged within the bony labyrinth and has the same general form; it is, however, considerably smaller and is partly separated from the bony walls by a quantity of fluid, the perilymph.[FMA, WP]." [FMA:61022, Wikipedia:Membranous_labyrinth] subset: organ_slim subset: pheno_slim subset: uberon_slim synonym: "labyrinthus membranaceus" EXACT OMO:0003011 [Wikipedia:Membranous_labyrinth] xref: AAO:0011060 xref: EHDAA2:0000899 xref: EHDAA:4698 xref: EV:0100367 xref: FMA:61022 xref: MA:0000242 xref: NCIT:C33090 xref: SCTID:263790009 xref: UMLS:C0458700 {source="ncithesaurus:Membranous_Labyrinth"} xref: VHOG:0000729 xref: Wikipedia:Membranous_labyrinth xref: XAO:0000194 is_a: BFO:0000002 is_a: UBERON:0000062 ! organ relationship: BFO:0000050 UBERON:0001846 {source="FMA", source="MA"} ! part of internal ear relationship: RO:0001025 UBERON:0004637 ! located in otic capsule relationship: RO:0002202 UBERON:0003051 ! develops from ear vesicle property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/8/8c/Gray924.png" xsd:anyURI property_value: skos:prefLabel "membranous labyrinth" xsd:string [Term] id: UBERON:0001850 name: lacrimal drainage system def: "A collection of channels that connects the conjunctival sac with the nasal cavity, encompassing the lacrimal ducts, the lacrimal sac and the naso-lacrimal duct." [http://orcid.org/0000-0002-6601-2165] subset: pheno_slim subset: uberon_slim synonym: "lacrimal duct" RELATED [FMA:61063, MA:0001295] synonym: "tear duct" RELATED [MA:0001295] xref: EMAPA:19245 xref: FMA:61063 xref: MA:0001295 xref: SCTID:280426002 is_a: UBERON:0000062 {source="FMA"} ! organ is_a: UBERON:0004111 ! anatomical conduit relationship: BFO:0000050 UBERON:0001750 {source="FMA"} ! part of lacrimal apparatus relationship: channel_for UBERON:0001827 ! secretion of lacrimal gland relationship: RO:0002176 UBERON:0001707 ! connects nasal cavity relationship: RO:0002176 UBERON:0010284 ! connects lacrimal punctum property_value: RO:0002161 NCBITaxon:8459 {source="PMID:7559104"} [Term] id: UBERON:0001851 name: cortex def: "Outermost layer of an organ[WP]." [Wikipedia:Cortex_(anatomy)] subset: pheno_slim subset: uberon_slim subset: upper_level synonym: "cortex" EXACT [FMA:61109] synonym: "cortex of organ" EXACT [] xref: EFO:0000383 xref: EHDAA:9344 xref: FMA:61109 xref: galen:Cortex xref: Wikipedia:Cortex_(anatomy) is_a: UBERON:0000064 ! organ part relationship: RO:0002007 UBERON:0000062 ! bounding layer of organ [Term] id: UBERON:0001853 name: utricle of membranous labyrinth def: "The larger of the two otolith organs in the vestibule." [ISBN:0-8036-0655-9, MGI:smb, MP:0006090, PMID:15363417, Wikipedia:Utricle_(ear)] comment: XAO/AAO to be checked - see https://github.com/seger/aao/issues/5; AAO has both utricle and utriculus; these are generally considered synonyms - e.g. http://www.fishbase.org/glossary/Glossary.php?q=utriculus subset: organ_slim subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "membranous labyrinth utricle" EXACT [] synonym: "utricle" EXACT [] synonym: "utriculus" EXACT [ZFA:0000700] synonym: "utriculus (labyrinthus vestibularis)" EXACT [] xref: AAO:0000625 xref: AAO:0011109 xref: BTO:0001807 xref: EHDAA2:0002153 xref: EHDAA:4726 xref: EMAPA:17293 xref: EV:0100368 xref: FMA:61113 xref: MA:0000247 xref: NCIT:C33844 xref: SCTID:279817006 xref: TAO:0000700 xref: UMLS:C0042158 {source="ncithesaurus:Utricle"} xref: VHOG:0000289 xref: Wikipedia:Utricle_(ear) xref: XAO:0000195 xref: ZFA:0000700 is_a: UBERON:0002518 {source="Wikipedia", source="ZFA"} ! otolith organ [Term] id: UBERON:0001854 name: saccule of membranous labyrinth def: "The smaller of the two otolith organs in the vestibule." [ISBN:0-8036-0655-9, MGI:smb, MP:0006089, PMID:15363417, Wikipedia:Saccule] comment: XAO/AAO to be checked - see https://github.com/seger/aao/issues/5 subset: organ_slim subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "membranous labyrinth saccule" EXACT [] synonym: "saccule" EXACT [] synonym: "sacculus" EXACT [ZFA:0000428] synonym: "sacculus" RELATED OMO:0003011 [Wikipedia:Saccule] synonym: "sacculus (labyrinthus vestibularis)" EXACT [] xref: AAO:0000550 xref: BTO:0001805 xref: EHDAA2:0001769 xref: EHDAA:4712 xref: EMAPA:17290 xref: EV:0100369 xref: FMA:61116 xref: MA:0000246 xref: NCIT:C33503 xref: SCTID:279827000 xref: TAO:0000428 xref: UMLS:C0036029 {source="ncithesaurus:Saccule"} xref: VHOG:0000374 xref: Wikipedia:Saccule xref: XAO:0000196 xref: ZFA:0000428 is_a: UBERON:0002518 {source="Wikipedia", source="ZFA"} ! otolith organ property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/c/cb/Bigotolith.jpg" xsd:anyURI [Term] id: UBERON:0001855 name: cochlear duct of membranous labyrinth def: "An endolymph filled cavity inside the cochlea, located in between the scala tympani and the scala vestibuli, separated by the basilar membrane and Reissner's membrane (the vestibular membrane) respectively. Houses the organ of Corti[WP]." [Wikipedia:Cochlear_duct] subset: pheno_slim subset: uberon_slim synonym: "cochlea duct" EXACT [BIRNLEX:2562] synonym: "cochlear aqueduct" RELATED [] synonym: "cochlear duct" EXACT [] synonym: "ductus cochlearis" RELATED OMO:0003011 [BTO:0001692, Wikipedia:Cochlear_duct] synonym: "membranous cochlea" RELATED [BTO:0001692] synonym: "Reissner's canal" EXACT [FMA:61119] synonym: "Reissners canal" EXACT [BIRNLEX:2562] synonym: "scala media" RELATED [Wikipedia:Cochlear_duct] synonym: "scala medias" EXACT [BIRNLEX:2562] synonym: "scala of Loewenberg" RELATED [BTO:0001692] xref: BIRNLEX:2562 xref: BTO:0001692 xref: CALOHA:TS-0152 xref: EHDAA2:0000262 xref: EHDAA:4718 xref: EMAPA:17598 xref: FMA:61119 xref: GAID:874 xref: MA:0000243 xref: MESH:D003053 xref: NCIT:C32335 xref: SCTID:279849006 xref: UMLS:C1281166 {source="BIRNLEX:2562"} xref: UMLS:C1323110 {source="ncithesaurus:Cochlear_Duct", source="BIRNLEX:2562"} xref: VHOG:0000507 xref: Wikipedia:Cochlear_duct is_a: UBERON:0000025 ! tube relationship: BFO:0000050 UBERON:0002499 {source="FMA", source="MA"} ! part of cochlear labyrinth property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/b/bc/Gray928.png" xsd:anyURI property_value: IAO:0000116 "TODO - check cochlear duct vs cochlear aqueduct vs scala media" xsd:string [Term] id: UBERON:0001856 name: semicircular duct def: "Any of the three loop-shaped membranous inner tubular parts of the semicircular canals that are about one-fourth the diameter of the corresponding outer bony canals, that communicate at each end with the utricle, and that have near one end an expanded ampulla containing an area of sensory epithelium." [http://dictionary.reference.com/browse/semicircular+duct] synonym: "ductus semicirculares" RELATED OMO:0003004 [FMA:71880, FMA:TA] synonym: "membranous semicircular canal" RELATED [MA:0000251] xref: EMAPA:32830 xref: FMA:61122 xref: MA:0000251 xref: NCIT:C33528 xref: SCTID:279833009 xref: UMLS:C1323109 {source="ncithesaurus:Semicircular_Duct"} xref: VHOG:0000238 is_a: UBERON:0000025 ! tube relationship: BFO:0000050 UBERON:0001840 {source="MA"} ! part of semicircular canal relationship: BFO:0000050 UBERON:0001862 {source="FMA", source="MA"} ! part of vestibular labyrinth property_value: IAO:0000116 "TODO - check canal vs duct. see Wikipedia:File:Gray927.png" xsd:string [Term] id: UBERON:0001862 name: vestibular labyrinth def: "The part of the membranous labyrinth that includes the utricle and saccule lodged within the vestibule and the semicircular ducts lodged eccentrically in the corresponding canals." [BTO:0001856] subset: pheno_slim synonym: "inner ear vestibular component" EXACT [EHDAA2:0000832] synonym: "labyrinthus vestibularis" RELATED [BTO:0001856] synonym: "vestibular apparatus" RELATED [] synonym: "vestibular component" BROAD [] xref: BTO:0001856 xref: CALOHA:TS-0479 xref: EHDAA2:0000832 xref: EHDAA:4706 xref: EMAPA:17286 xref: FMA:61255 xref: MA:0000245 xref: NCIT:C33871 xref: UMLS:C0042606 {source="ncithesaurus:Vestibular_Labyrinth"} xref: Wikipedia:Inner_ear xref: XAO:0004145 is_a: UBERON:0000064 ! organ part relationship: BFO:0000050 UBERON:0001849 ! part of membranous labyrinth property_value: skos:prefLabel "vestibular labyrinth" xsd:string [Term] id: UBERON:0001866 name: sebum def: "Fatty lubricant matter secreted by sebaceous glands, and made of made of triglyceride oils, wax, squalene, and metabolytes of fat-producing cells[BTO,WP]." [BTO:0001981, Wikipedia:Sebaceous_glands#Sebum] subset: uberon_slim xref: BTO:0001981 xref: ENVO:02000037 xref: FMA:61304 xref: GAID:1168 xref: MA:0002538 xref: MESH:D012629 xref: NCIT:C13276 xref: UMLS:C0036511 {source="ncithesaurus:Sebum"} xref: Wikipedia:Sebaceous_glands#Sebum is_a: UBERON:0000456 ! secretion of exocrine gland intersection_of: UBERON:0000456 ! secretion of exocrine gland intersection_of: RO:0003001 UBERON:0001821 ! produced by sebaceous gland relationship: BFO:0000051 CHEBI:15440 ! has part relationship: RO:0003001 UBERON:0001821 ! produced by sebaceous gland [Term] id: UBERON:0001867 name: cartilage of external ear def: "A cartilage that is part of a external ear [Automatically generated definition]." [OBOL:automatic] subset: pheno_slim synonym: "external ear cartilage" EXACT [] xref: EMAPA:37706 {source="MA:th"} xref: FMA:61339 xref: GAID:103 xref: MA:0001886 xref: MESH:D004425 xref: NCIT:C49225 xref: UMLS:C0013445 {source="ncithesaurus:External_Ear_Cartilage"} is_a: UBERON:0007844 ! cartilage element intersection_of: UBERON:0007844 ! cartilage element intersection_of: BFO:0000050 UBERON:0001691 ! part of external ear relationship: BFO:0000050 UBERON:0001691 ! part of external ear relationship: RO:0002473 UBERON:0001996 ! composed primarily of elastic cartilage tissue [Term] id: UBERON:0001868 name: skin of chest def: "A zone of skin that is part of a chest [Automatically generated definition]." [OBOL:automatic] subset: pheno_slim synonym: "anterior thoracic region zone of skin" EXACT [OBOL:automatic] synonym: "anterolateral part of thorax zone of skin" EXACT [OBOL:automatic] synonym: "chest skin" EXACT [] synonym: "chest zone of skin" EXACT [OBOL:automatic] synonym: "front of thorax zone of skin" EXACT [OBOL:automatic] synonym: "zone of skin of anterior chest" EXACT [FMA:61416] synonym: "zone of skin of anterior part of thorax" EXACT [FMA:61416] synonym: "zone of skin of anterior thoracic region" EXACT [OBOL:automatic] synonym: "zone of skin of anterolateral part of thorax" EXACT [OBOL:automatic] synonym: "zone of skin of chest" EXACT [OBOL:automatic] synonym: "zone of skin of front of thorax" EXACT [OBOL:automatic] synonym: "zone of skin of pectoral part of chest" RELATED [FMA:61417] xref: EMAPA:37279 {source="MA:th"} xref: FMA:61416 xref: MA:0000553 xref: SCTID:181496004 is_a: UBERON:0001418 ! skin of thorax intersection_of: UBERON:0000014 ! zone of skin intersection_of: BFO:0000050 UBERON:0001443 ! part of chest relationship: BFO:0000050 UBERON:0001443 ! part of chest property_value: IAO:0000116 "check FMA:61415" xsd:string [Term] id: UBERON:0001869 name: cerebral hemisphere def: "One of two bilateral, largely symmetrical organ subdivisions within the telencephalon which contain the cerebral cortex and cerebral white matter.[FMA]." [FMA:61817, Wikipedia:Cerebral_hemisphere] subset: efo_slim subset: pheno_slim subset: uberon_slim synonym: "cerebrum" RELATED [https://github.com/obophenotype/uberon/issues/1208, MA:0000133, VHOG:0001639] synonym: "hemisphere" RELATED [VHOG:0001639] synonym: "hemispheric regions" RELATED [BAMS:HEM] synonym: "hemispherium cerebri" RELATED OMO:0003011 [Wikipedia:Cerebral_hemisphere] synonym: "medial amygdalar nucleus" RELATED [NeuroNames:241] synonym: "nucleus amygdaloideus medialis" RELATED OMO:0003011 [NeuroNames:241] synonym: "nucleus medialis amygdalae" RELATED OMO:0003011 [NeuroNames:241] xref: AAO:0010480 xref: BAMS:HEM xref: BIRNLEX:1042 xref: BTO:0000231 xref: CALOHA:TS-2007 xref: DMBA:15739 xref: EFO:0002521 xref: EMAPA:16653 xref: FMA:61817 xref: galen:CerebralHemisphere xref: MA:0000133 xref: MBA:403 xref: NCIT:C12351 xref: neuronames:241 {source="BIRNLEX:1042"} xref: SCTID:278251007 xref: UMLS:C0228174 {source="ncithesaurus:Cerebral_Hemisphere"} xref: UMLS:C0242202 {source="BIRNLEX:1042"} xref: VHOG:0001639 xref: Wikipedia:Cerebral_hemisphere is_a: UBERON:0000064 ! organ part is_a: UBERON:0015212 ! lateral structure relationship: BSPO:0000126 UBERON:0000955 ! brain relationship: BSPO:0000126 UBERON:0001893 {source="FMA-abduced-lr"} ! telencephalon property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/9/92/Hemispheres.png" xsd:anyURI property_value: skos:prefLabel "cerebral hemisphere" xsd:string [Term] id: UBERON:0001870 name: frontal cortex def: "Anterior portion of the neocortex, lying anterior to the central sulcus in humans. It is bounded by the parietal cortex posteriorly and the temporal cortex laterally[NIFSTD,modified]." [NLXANAT:20090601] subset: efo_slim subset: human_reference_atlas subset: pheno_slim subset: uberon_slim synonym: "cortex of frontal lobe" EXACT [FMA:242199] synonym: "frontal lobe cortex" EXACT [FMA:242199] synonym: "frontal neocortex" RELATED [DHBA:10161] synonym: "gray matter of frontal lobe" EXACT [FMA:242199] synonym: "grey matter of frontal lobe" EXACT [] xref: BTO:0000484 xref: DHBA:10161 xref: DMBA:16002 xref: EMAPA:35357 xref: FMA:242199 xref: GAID:674 xref: MA:0000905 xref: MESH:D005625 {sssom:mapping_justification="https://w3id.org/semapv/vocab/LexicalMatching"} xref: NLXANAT:20090601 xref: Wikipedia:Frontal_lobe is_a: UBERON:0016529 ! cortex of cerebral lobe intersection_of: UBERON:0016529 ! cortex of cerebral lobe intersection_of: BFO:0000050 UBERON:0016525 ! part of frontal lobe relationship: BFO:0000050 UBERON:0016525 ! part of frontal lobe property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/b/b4/Gray729.png" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "frontal cortex" xsd:string [Term] id: UBERON:0001871 name: temporal lobe def: "Lower lateral part of the cerebral hemisphere. (MSH)." [BIRNLEX:1160] comment: Boundary notes: It is bounded dorsally by the lateral fissure and posteriorly by an arbitrary border shared with the occipital lobe. [Wikipedia:Temporal_lobe] subset: efo_slim subset: human_reference_atlas subset: pheno_slim subset: uberon_slim synonym: "lobus temporalis" EXACT OMO:0003011 [Wikipedia:Temporal_lobe] synonym: "temporal cortex" NARROW [] xref: BAMS:Temporal_lobe xref: BAMS:TL xref: BIRNLEX:1160 xref: BTO:0001355 xref: CALOHA:TS-1020 xref: DHBA:12139 xref: EFO:0000917 xref: EMAPA:18797 xref: EV:0100169 xref: FMA:61825 xref: GAID:635 xref: HBA:4132 xref: MAT:0000508 xref: MESH:D013702 xref: NCIT:C12353 xref: neuronames:125 {source="BIRNLEX:1160"} xref: SCTID:180921000 xref: UMLS:C0039485 {source="BIRNLEX:1160", source="ncithesaurus:Temporal_Lobe"} xref: UMLS:C1268978 {source="BIRNLEX:1160"} xref: Wikipedia:Temporal_lobe is_a: UBERON:0016526 {source="FMA"} ! lobe of cerebral hemisphere relationship: RO:0002433 UBERON:0001893 ! contributes to morphology of telencephalon property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/9/91/Gray730.png" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "temporal lobe" xsd:string [Term] id: UBERON:0001872 name: parietal lobe def: "Upper central part of the cerebral hemisphere. (MSH)." [BIRNLEX:1148] subset: efo_slim subset: human_reference_atlas subset: pheno_slim subset: uberon_slim synonym: "lobus parietalis" RELATED OMO:0003011 [Wikipedia:Parietal_lobe] synonym: "parietal region" BROAD [] synonym: "regio parietalis" EXACT OMO:0003011 [FMA:61826, FMA:TA] xref: BAMS:Parietal_lobe xref: BIRNLEX:1148 xref: BTO:0001001 xref: CALOHA:TS-0747 xref: DHBA:12131 xref: EFO:0000914 xref: EV:0100168 xref: FMA:61826 xref: GAID:680 xref: HBA:4084 xref: MAT:0000506 xref: MESH:D010296 xref: NCIT:C12354 xref: neuronames:95 {source="BIRNLEX:1148"} xref: SCTID:180922007 xref: UMLS:C0030560 {source="BIRNLEX:1148", source="ncithesaurus:Parietal_Lobe_of_the_Brain"} xref: Wikipedia:Parietal_lobe is_a: UBERON:0016526 {source="FMA"} ! lobe of cerebral hemisphere relationship: RO:0002220 UBERON:0001871 ! adjacent to temporal lobe relationship: RO:0002433 UBERON:0001893 ! contributes to morphology of telencephalon property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/b/b2/Gray726_parietal_lobe.png" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "parietal lobe" xsd:string [Term] id: UBERON:0001873 name: caudate nucleus def: "Subcortical nucleus of telecephalic origin consisting of an elongated gray mass lying lateral to and bordering the lateral ventricle. It is divided into a head, body and tail in some species." [BIRNLEX:1373] subset: efo_slim subset: human_reference_atlas subset: pheno_slim subset: uberon_slim synonym: "Ammon horn fields" RELATED [BAMS:CA] synonym: "caudatum" RELATED [BTO:0000211] synonym: "caudatus" EXACT [] synonym: "nucleus caudatus" RELATED OMO:0003011 [BTO:0000211, Wikipedia:Caudate_nucleus] xref: BAMS:CA xref: BAMS:Cd xref: BIRNLEX:1373 xref: BM:Tel-CA xref: BTO:0000211 xref: CALOHA:TS-0121 xref: DHBA:10334 xref: DMBA:15855 xref: EFO:0000907 xref: EHDAA2:0004461 xref: EMAPA:18207 xref: EV:0100185 xref: FMA:61833 xref: GAID:670 xref: HBA:4278 xref: MA:0000894 xref: MAT:0000513 xref: MESH:D002421 xref: NCIT:C12451 xref: neuronames:226 {source="BIRNLEX:1373"} xref: PBA:10082 xref: SCTID:279297002 xref: UMLS:C0007461 {source="ncithesaurus:Caudate_Nucleus", source="BIRNLEX:1373"} xref: Wikipedia:Caudate_nucleus is_a: UBERON:0009663 ! telencephalic nucleus relationship: BFO:0000050 UBERON:0005383 {source="MA"} ! part of caudate-putamen relationship: RO:0002433 UBERON:0005383 ! contributes to morphology of caudate-putamen property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/9/91/Telencephalon-Horiconatal.jpg" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "caudate nucleus" xsd:string [Term] id: UBERON:0001874 name: putamen def: "Subcortical nucleus of telencephalic , which together with the caudate nucleus, forms the striatum. The putamen lies lateral to the internal capsule and medial to the external medullary lamina, and is separated from the caudate nucleus by the fibers of the internal capsule for most of its length, except at its anterior portion." [BIRNLEX:809] subset: human_reference_atlas subset: pheno_slim subset: uberon_slim synonym: "nucleus putamen" EXACT [] xref: BAMS:PU xref: BAMS:Pu xref: BIRNLEX:809 xref: BM:Tel-Pu xref: CALOHA:TS-2041 xref: DHBA:10338 xref: DMBA:15857 xref: EMAPA:35719 xref: EV:0100187 xref: FMA:61834 xref: GAID:671 xref: HBA:4287 xref: MA:0000895 xref: MESH:D011699 xref: NCIT:C12452 xref: neuronames:230 {source="BIRNLEX:809"} xref: PBA:10086 xref: SCTID:281512002 xref: UMLS:C0034169 {source="ncithesaurus:Putamen"} xref: VHOG:0001456 xref: Wikipedia:Putamen is_a: UBERON:0009663 ! telencephalic nucleus relationship: BFO:0000050 UBERON:0001869 {source="FMA"} ! part of cerebral hemisphere relationship: BFO:0000050 UBERON:0005383 ! part of caudate-putamen relationship: RO:0002433 UBERON:0005383 ! contributes to morphology of caudate-putamen property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/3/33/BrainCaudatePutamen.svg" xsd:anyURI property_value: IAO:0000116 "check - rodents. The caudate nucleus and putamen are separated by a clear white matter bundle in most species but not in rodents (MM)" xsd:string property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "putamen" xsd:string [Term] id: UBERON:0001875 name: globus pallidus def: "Subcortical nucleus, functionally part of the basal ganglia, which consists of two segments the external (or lateral) and internal (or medial) separated by the medial medullary lamina in primates. In rodents, The globus pallidus lateral is separated from the medial segment by the fibers of the internal capsule/cerebral peduncle." [BIRNLEX:1234] comment: BTO and MA are inconsistent w.r.t striatum and pallidum being non-overlapping as in ABA. Note that we have pallidum as part_of basal gangion, so we can make the direct link to basal ganglion. ISBN:1588900649 says: ... a derivative of the diencephalon, seperates as a result of growing fibers of theinternal capsule and is finally displaced into telencephalon. only a small medial remnannt remains, the entopeduncular nucleus. The globus pallidus should be regarded as part of the subthalamus subset: efo_slim subset: pheno_slim subset: uberon_slim synonym: "globus pallidus (Burdach)" RELATED [NeuroNames:231] synonym: "nucleus pallidus" RELATED OMO:0003011 [NeuroNames:231] synonym: "pale body" EXACT [BIRNLEX:1234] synonym: "paleostriatum" EXACT [Wikipedia:Globus_pallidus] synonym: "pallidium" RELATED [Wikipedia:Globus_pallidus] synonym: "pallidum" RELATED [BIRNLEX:1234, GO:0021759, Wikipedia:Globus_pallidus] xref: BAMS:GP xref: BIRNLEX:1234 xref: BTO:0002246 xref: CALOHA:TS-2013 xref: DHBA:10342 xref: EFO:0000905 xref: EMAPA:35380 xref: EV:0100188 xref: FMA:61835 xref: GAID:668 xref: HBA:4293 xref: MA:0000890 xref: MAT:0000510 xref: MESH:D005917 xref: NCIT:C12449 xref: neuronames:231 {source="BIRNLEX:1234"} xref: PBA:10097 xref: SCTID:362361005 xref: UMLS:C0017651 {source="BIRNLEX:1234", source="ncithesaurus:Globus_Pallidus"} xref: Wikipedia:Globus_pallidus is_a: UBERON:0004121 ! ectoderm-derived structure is_a: UBERON:0009663 ! telencephalic nucleus relationship: BFO:0000050 UBERON:0001869 ! part of cerebral hemisphere relationship: BFO:0000050 UBERON:0006514 {source="MA"} ! part of pallidum relationship: RO:0002131 UBERON:0002263 {source="BTO-weakened"} ! overlaps lentiform nucleus relationship: RO:0002225 UBERON:0001894 {source="GO", source="ISBN:1588900649"} ! develops from part of diencephalon relationship: RO:0002433 UBERON:0010011 ! contributes to morphology of collection of basal ganglia property_value: foaf:depiction "https://upload.wikimedia.org/wikipedia/commons/e/ee/Brain_structure.gif" xsd:anyURI property_value: skos:prefLabel "globus pallidus" xsd:string [Term] id: UBERON:0001876 name: amygdala def: "Subcortical brain region lying anterior to the hippocampal formation in the temporal lobe and anterior to the temporal horn of the lateral ventricle in some species. It is usually subdivided into several groups. Functionally, it is not considered a unitary structure (MM)." [BIRNLEX:1241] subset: efo_slim subset: human_reference_atlas subset: pheno_slim subset: uberon_slim synonym: "amygdaloid area" RELATED [] synonym: "amygdaloid body" EXACT [] synonym: "amygdaloid complex" EXACT [BIRNLEX:1241] synonym: "amygdaloid nuclear complex" EXACT [] synonym: "amygdaloid nuclear group" RELATED [BTO:0001042] synonym: "amygdaloid nuclear groups" EXACT [] synonym: "amygdaloid nucleus" RELATED [FMA:61841] synonym: "archistriatum" EXACT [] synonym: "corpus amygdalae" RELATED OMO:0003011 [NeuroNames:237] synonym: "corpus amygdaloideum" RELATED OMO:0003011 [BTO:0001042, Wikipedia:Amygdala] synonym: "nucleus amygdalae" RELATED [BTO:0001042] xref: BAMS:Amg xref: BAMS:AMY xref: BAMS:Amy xref: BAMS:Amygdala xref: BAMS:Amygdaloid_complex xref: BIRNLEX:1241 xref: BM:Tel-Am xref: BTO:0001042 xref: CALOHA:TS-0037 xref: DHBA:10361 xref: EFO:0000252 xref: EMAPA:32672 xref: EMAPA:36051 xref: EV:0100189 xref: EV:0100190 xref: FMA:61841 xref: GAID:616 xref: HBA:4327 xref: MA:0000887 xref: MAT:0000289 xref: MESH:D000679 xref: MIAA:0000289 xref: NCIT:C12440 xref: neuronames:237 {source="BIRNLEX:1241"} xref: PBA:4002 xref: SCTID:279404004 xref: UMLS:C0002708 {source="BIRNLEX:1241", source="ncithesaurus:Amygdala"} xref: VHOG:0001277 xref: Wikipedia:Amygdala is_a: UBERON:0002420 {source="FMA"} ! basal ganglion is_a: UBERON:0005401 ! cerebral hemisphere gray matter relationship: BFO:0000050 UBERON:0000349 {source="FMA"} ! part of limbic system relationship: BFO:0000050 UBERON:0001871 {source="BTO"} ! part of temporal lobe property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/8/8b/Amyg.png" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "amygdala" xsd:string [Term] id: UBERON:0001877 name: medial septal nucleus def: "Cells lying generally in front of Regional_part_of_septal_nuclei, lying ventral to and slightly medial to the lateral septal nucleus. Neurons in this nucleus give rise to the bulk of efferents from the septal nuclei. A major projection from the medial septal nucleus terminates in the hippocampal formation (Adapted from Brodal, 1981)." [BIRNLEX:1668, https://github.com/obophenotype/uberon/issues/1356] synonym: "medial parolfactory nucleus" EXACT [FMA:61879] synonym: "medial septal nucleus (Cajal)" RELATED [NeuroNames:262] synonym: "medial septum" NARROW [BIRNLEX:1668] synonym: "medial septum nucleus" RELATED [NeuroNames:262] synonym: "n. septi medialis" RELATED OMO:0003011 [NeuroNames:262] synonym: "nucleus medialis septi" RELATED OMO:0003011 [NeuroNames:262] synonym: "nucleus septalis medialis" RELATED [BTO:0002446] xref: BAMS:MS xref: BAMS:SMN xref: BIRNLEX:1668 xref: BM:Tel-Spt-SMN xref: BTO:0002446 xref: DHBA:10351 xref: DMBA:15764 xref: EMAPA:35553 xref: FMA:61879 xref: HBA:4302 xref: MA:0000935 xref: MBA:564 xref: neuronames:262 {source="BIRNLEX:1668"} xref: UMLS:C0175233 {source="BIRNLEX:1668"} xref: Wikipedia:Medial_septal_nucleus is_a: UBERON:0009663 ! telencephalic nucleus disjoint_from: UBERON:0002667 {source="lexical"} ! lateral septal nucleus relationship: BFO:0000050 UBERON:0007629 ! part of medial septal complex property_value: skos:prefLabel "medial septal nucleus" xsd:string [Term] id: UBERON:0001879 name: nucleus of diagonal band def: "A brain structure that is part of the septal nuclear complex. It is connected with the hippocampus, hypothalamus and amygdala." [ncithesaurus:Nucleus_of_Diagonal_Band] synonym: "area olfactoria (Roberts)" RELATED OMO:0003011 [NeuroNames:265] synonym: "diagonal band nucleus" EXACT [] synonym: "diagonal nucleus" RELATED [NeuroNames:265] synonym: "nuclei of horizontal and vertical limbs of diagonal band" RELATED [NeuroNames:265] synonym: "nucleus fasciculi diagonalis Brocae" RELATED OMO:0003011 [NeuroNames:265] synonym: "nucleus of diagonal band (of Broca)" EXACT [] synonym: "nucleus of the diagonal band" RELATED [NeuroNames:265] synonym: "nucleus of the diagonal band of Broca" EXACT [] synonym: "olfactory area (roberts)" EXACT [] xref: BAMS:DB xref: BAMS:NDB xref: BIRNLEX:719 xref: DHBA:10354 xref: EHDAA2:0004708 xref: EMAPA:35598 xref: FMA:61882 xref: HBA:4309 xref: MA:0000936 xref: MBA:596 xref: NCIT:C97342 xref: neuronames:265 {source="BIRNLEX:719"} xref: UMLS:C0175227 {source="BIRNLEX:719", source="ncithesaurus:Nucleus_of_Diagonal_Band"} xref: Wikipedia:Nucleus_of_diagonal_band is_a: UBERON:0009663 ! telencephalic nucleus relationship: BFO:0000050 UBERON:0007629 {source="MA"} ! part of medial septal complex property_value: skos:prefLabel "nucleus of diagonal band" xsd:string [Term] id: UBERON:0001881 name: island of Calleja def: "One of the seven small groups of granule cells in the polymorph layer of the olfactory tubercle and one large group, the insula magna, which lies along the border between septum, nucleus accumbens and nucleus of the diagonal band." [MP:0010010, PMID:80412] subset: pheno_slim subset: uberon_slim synonym: "Calleja island" EXACT [] synonym: "insula callejae" RELATED OMO:0003011 [Wikipedia:Islands_of_Calleja] synonym: "insulae olfactoriae" RELATED OMO:0003011 [Wikipedia:Islands_of_Calleja] synonym: "islands of Calleja" EXACT [] synonym: "islands of Calleja (olfactory tubercle)" RELATED [NeuroNames:276] xref: BAMS:ICj xref: BAMS:IClj xref: BAMS:ISC xref: BAMS:isl xref: BIRNLEX:1113 xref: BM:Tel-ISC xref: DHBA:10358 xref: EMAPA:35452 xref: FMA:61888 xref: GAID:632 xref: HBA:265504792 xref: MA:0000977 xref: MBA:481 xref: MESH:D020670 xref: neuronames:276 {source="BIRNLEX:1113"} xref: PBA:10095 xref: UMLS:C0262264 {source="BIRNLEX:1113"} xref: Wikipedia:Islands_of_Calleja is_a: UBERON:0009663 ! telencephalic nucleus relationship: BFO:0000050 UBERON:0001869 ! part of cerebral hemisphere relationship: RO:0002433 UBERON:0001882 ! contributes to morphology of nucleus accumbens relationship: RO:0002433 UBERON:0001883 ! contributes to morphology of olfactory tubercle property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/c/c0/Islands_of_Calleja_Rat.jpg" xsd:anyURI property_value: skos:prefLabel "island of Calleja" xsd:string [Term] id: UBERON:0001882 name: nucleus accumbens def: "A region of the brain consisting of a collection of neurons located in the forebrain ventral to the caudate and putamen. (caudoputamen in rodent) and continuous with these structures. There is no distinct boundary between the nucleus accumbens and the caudate/putamen, but in rodents, it can be identified by its lack of traversing fiber bundles in comparison to the dorsal striatum. Its principle neuron is the medium spiny neuron. Together with the neostriatum (caudate nucleus and putamen), the nucleus accumbens forms the striatum." [BIRNLEX:727] subset: efo_slim subset: human_reference_atlas subset: pheno_slim subset: uberon_slim synonym: "accumbens nucleus" EXACT [FMA:61889] synonym: "colliculus nuclei caudati" RELATED OMO:0003011 [NeuroNames:277] synonym: "colliculus of caudate nucleus" EXACT [FMA:61889] synonym: "nucleus accumbens septi" EXACT [FMA:61889, Wikipedia:Nucleus_accumbens] xref: BAMS:ACB xref: BAMS:Acb xref: BAMS:ACC xref: BIRNLEX:727 xref: BM:Ac xref: BTO:0001862 xref: DHBA:10339 xref: EFO:0000906 xref: EHDAA2:0004707 xref: EMAPA:32789 xref: FMA:61889 xref: GAID:672 xref: HBA:4290 xref: MA:0000892 xref: MAT:0000512 xref: MBA:56 xref: MESH:D009714 xref: NCIT:C52733 xref: neuronames:277 {source="BIRNLEX:727"} xref: PBA:10092 xref: SCTID:427667007 xref: UMLS:C0028633 {source="ncithesaurus:Accumbens_Nucleus"} xref: Wikipedia:Nucleus_accumbens is_a: UBERON:0009663 ! telencephalic nucleus relationship: BFO:0000050 UBERON:0000349 {source="FMA", source="GO"} ! part of limbic system relationship: BFO:0000050 UBERON:0001869 ! part of cerebral hemisphere relationship: BFO:0000050 UBERON:0005403 {source="MA"} ! part of ventral striatum relationship: RO:0002433 UBERON:0005403 ! contributes to morphology of ventral striatum property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/9/93/Circuit_du_syst%C3%A8me_de_recompense.jpg" xsd:anyURI property_value: RO:0002175 NCBITaxon:8782 {source="ISBN:0471888893"} property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "nucleus accumbens" xsd:string [Term] id: UBERON:0001883 name: olfactory tubercle def: "Region in the ventral telencephalon, prominent in rodents, but present in all mammals, consisting of a laminated cortical part and the cap/hilus region. It is traditionally viewed as part of the olfactory cortex but recognized by some as having a striatal character. According to many authors, the structure of the OT transitions from cortical like to striatal like along the lateral medial axis. (Maryann Martone)." [NLXANAT:1005037] subset: human_reference_atlas subset: pheno_slim subset: uberon_slim synonym: "tuberculum olfactorium" EXACT OMO:0003011 [] xref: BAMS:DLT xref: BAMS:OLT xref: BAMS:OT xref: BAMS:Tu xref: BM:Tel-OLT xref: BTO:0001869 xref: DHBA:10310 xref: EHDAA2:0004701 xref: EMAPA:35616 xref: EV:0100177 xref: HBA:10145 xref: MA:0000976 xref: MBA:754 xref: MESH:D066208 xref: NLXANAT:1005037 xref: PBA:10096 xref: VHOG:0001625 xref: Wikipedia:Olfactory_tubercle is_a: UBERON:0009663 ! telencephalic nucleus relationship: BFO:0000050 UBERON:0002894 {source="EHDAA2-inferred", source="MA", source="VHOG", source="Wikipedia"} ! part of olfactory cortex relationship: RO:0002433 UBERON:0002894 ! contributes to morphology of olfactory cortex property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/4/4d/Gray732.png" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "olfactory tubercle" xsd:string [Term] id: UBERON:0001884 name: phrenic nerve def: "A nerve that arises from the caudal cervical nerves and is primarily the motor nerve of the diaphragm but also sends sensory fibers to the pericardium." [VHOG:0000728] subset: human_reference_atlas subset: pheno_slim subset: uberon_slim synonym: "diaphragmatic nerve" RELATED [BTO:0001063] synonym: "nervus phrenicus" RELATED OMO:0003011 [BTO:0001063, Wikipedia:Phrenic_nerve] synonym: "phrenic" RELATED [BTO:0001063] xref: BAMS:phn xref: BTO:0001063 xref: EHDAA:4677 xref: EMAPA:17813 xref: FMA:6191 xref: GAID:848 xref: MA:0001170 xref: MESH:D010791 xref: NCIT:C52813 xref: SCTID:280344009 xref: UMLS:C0031774 {source="ncithesaurus:Phrenic_Nerve"} xref: VHOG:0000728 xref: Wikipedia:Phrenic_nerve is_a: UBERON:0003443 ! thoracic cavity nerve intersection_of: UBERON:0001021 ! nerve intersection_of: RO:0002134 UBERON:0001103 ! innervates diaphragm relationship: RO:0002134 UBERON:0001103 ! innervates diaphragm relationship: RO:0002380 UBERON:0000962 ! branching part of nerve of cervical vertebra property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/3/3c/Gray806.png" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "phrenic nerve" xsd:string [Term] id: UBERON:0001885 name: dentate gyrus of hippocampal formation def: "Part of the hippocampal formation forming a 'V' or 'U' shaped structure with the opening bounded by hippocampal area CA3. It consists of 3 layers from superficial to deep: molecular, granule cell and polymorphic or hilar layer." [BIRNLEX:1178] comment: BTO says dentate gyrus = fascia dentata + hilus. Note that GO classifies dentate gyrus development under hippocampus development subset: efo_slim subset: pheno_slim subset: uberon_slim synonym: "area dentata" EXACT [] synonym: "dentate area" RELATED [DHBA:10295] synonym: "dentate area (dentate gyrus)" EXACT [DHBA:10295] synonym: "dentate gyrus" EXACT [] synonym: "fascia dentata" NARROW [] synonym: "gyrus dentatus" RELATED OMO:0003011 [BTO:0002496, Wikipedia:Dentate_gyrus] synonym: "hippocampal dentate gyrus" RELATED [BTO:0002496] xref: BAMS:DG xref: BIRNLEX:1178 xref: BM:Tel-DG xref: BTO:0002496 xref: BTO:0002615 xref: CALOHA:TS-2388 xref: DHBA:10295 xref: DMBA:16115 xref: EFO:0001366 xref: EMAPA:19037 xref: FMA:61922 xref: GAID:624 xref: HBA:12891 xref: MA:0000190 xref: MBA:726 xref: MESH:D018891 xref: NCIT:C32452 xref: neuronames:179 xref: SCTID:279211002 xref: UMLS:C0152314 {source="ncithesaurus:Dentate_Gyrus"} xref: Wikipedia:Dentate_gyrus is_a: UBERON:0002616 ! regional part of brain relationship: BFO:0000050 UBERON:0002421 {source="MA"} ! part of hippocampal formation property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/a/ab/HippocampalRegions.jpg" xsd:anyURI property_value: skos:prefLabel "dentate gyrus of hippocampal formation" xsd:string [Term] id: UBERON:0001886 name: choroid plexus def: "A network formed by blood vessels and the tela choroidea which secretes CSF into the ventricular spaces." [ISBN:0471888893, Wikipedia:Choroid_plexus] subset: efo_slim subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "chorioid plexus" EXACT [FMA:61934] synonym: "choroid plexus of cerebral hemisphere" RELATED [FMA:61934] synonym: "CP" BROAD OMO:0003000 [PMID:23375746] synonym: "plexus choroideus" EXACT OMO:0003011 [FMA:61934, FMA:TA] synonym: "plexus choroideus" RELATED OMO:0003011 [Wikipedia:Choroid_plexus] synonym: "ventricular choroid plexus" RELATED [] xref: BAMS:CHP xref: BAMS:chp xref: BAMS:chpl xref: BAMS:GHP xref: BTO:0000258 xref: CALOHA:TS-0145 xref: EFO:0001915 xref: EMAPA:32741 xref: FMA:61934 xref: GAID:607 xref: MA:0000823 xref: MBA:108 xref: MESH:D002831 xref: NCIT:C12694 xref: neuronames:1377 xref: SCTID:264450003 xref: TAO:0001443 xref: UMLS:C0008524 {source="ncithesaurus:Choroid_Plexus"} xref: VHOG:0001377 xref: Wikipedia:Choroid_plexus xref: ZFA:0001443 is_a: UBERON:0003947 ! brain ventricle/choroid plexus is_a: UBERON:0005629 ! vascular plexus is_a: UBERON:0006876 ! vasculature of organ is_a: UBERON:0036303 ! vasculature of central nervous system relationship: BFO:0000050 UBERON:0004086 ! part of brain ventricle relationship: BFO:0000050 UBERON:0005283 ! part of tela choroidea relationship: RO:0002433 UBERON:0003947 ! contributes to morphology of brain ventricle/choroid plexus property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/b/b9/Gray708.svg" xsd:anyURI property_value: IAO:0000116 "TODO - check relationship to ventricle. Check subclass - ZFA says vasculature. Note that FMA:61934 (choroid plexus of cerebral hemisphere) has exact synonym 'choroid plexus' but it is not clear that this belongs here, as the fourth ventricle is not in the cerebral hemisphere" xsd:string property_value: skos:prefLabel "choroid plexus" xsd:string [Term] id: UBERON:0001888 name: lateral olfactory stria def: "White matter tract that contains projections from the olfactory bulb to the olfactory cortex (Maryann Martone)." [BIRNLEX:1559] subset: uberon_slim subset: vertebrate_core synonym: "lateral olfactory stria" RELATED [FMA:61971, NeuroNames:284] synonym: "lateral olfactory tract" RELATED [NeuroNames:284] synonym: "lateral olfactory tract, body" RELATED [NeuroNames:284] synonym: "lateral olfactory tract. body" RELATED [BAMS:lot] synonym: "LOT" RELATED OMO:0003000 [] synonym: "olfactory tract" RELATED [NeuroNames:284] synonym: "stria olfactoria lateralis" RELATED OMO:0003011 [NeuroNames:284, Wikipedia:Lateral_olfactory_stria] synonym: "tractus olfactorius lateralis" EXACT OMO:0003011 [ZFA:0000229] synonym: "tractus olfactorius lateralis" RELATED OMO:0003011 [NeuroNames:284] xref: BAMS:LDTR xref: BAMS:lo xref: BAMS:lot xref: BAMS:LOTR xref: BIRNLEX:1559 xref: BM:Tel-LOT xref: DHBA:12075 xref: DMBA:17773 xref: EV:0100175 xref: FMA:61971 xref: HBA:265505514 xref: MBA:665 xref: neuronames:284 {source="BIRNLEX:1559"} xref: SCTID:369107001 xref: UMLS:C0152330 {source="BIRNLEX:1559"} xref: Wikipedia:Lateral_olfactory_stria is_a: UBERON:0034730 ! olfactory tract linking bulb to ipsilateral dorsal telencephalon intersection_of: UBERON:0002265 ! olfactory tract intersection_of: RO:0002131 UBERON:0002894 ! overlaps olfactory cortex relationship: RO:0002131 UBERON:0002894 ! overlaps olfactory cortex property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/4/4d/Gray732.png" xsd:anyURI property_value: skos:prefLabel "lateral olfactory stria" xsd:string [Term] id: UBERON:0001889 name: trunk of phrenic nerve synonym: "phrenic nerve trunk" EXACT [] synonym: "phrenic neural trunk" EXACT [] xref: EHDAA2:0001463 xref: EMAPA:37718 {source="MA:th"} xref: FMA:6198 xref: MA:0001177 is_a: UBERON:0005476 ! spinal nerve trunk intersection_of: UBERON:0002464 ! nerve trunk intersection_of: BFO:0000050 UBERON:0001884 ! part of phrenic nerve relationship: BFO:0000050 UBERON:0001884 ! part of phrenic nerve [Term] id: UBERON:0001890 name: forebrain def: "The most anterior region of the brain including both the telencephalon and diencephalon." [Wikipedia:Forebrain, ZFIN:ZDB-PUB-961014-576] subset: efo_slim subset: human_reference_atlas subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "FB" BROAD OMO:0003000 [BIRNLEX:1509, NIFSTD:NeuroNames_abbrevSource] synonym: "prosencephalon" RELATED [] xref: AAO:0010147 xref: BAMS:FB xref: BAMS:Forebrain xref: BIRNLEX:1509 xref: BTO:0000478 xref: CALOHA:TS-0380 xref: DHBA:10156 xref: DMBA:15566 xref: EFO:0000909 xref: EHDAA2:0000556 xref: EHDAA:3470 xref: EMAPA:16895 xref: FMA:61992 xref: MA:0000170 xref: MAT:0000105 xref: MESH:D016548 xref: MIAA:0000105 xref: NCIT:C40185 xref: neuronames:27 {source="BIRNLEX:1509"} xref: SCTID:362291003 xref: TAO:0000109 xref: UMLS:C0085140 {source="ncithesaurus:Fore-Brain", source="BIRNLEX:1509"} xref: VHOG:0000383 xref: Wikipedia:Forebrain xref: XAO:0000011 xref: ZFA:0000109 is_a: UBERON:0002616 ! regional part of brain is_a: UBERON:0004121 ! ectoderm-derived structure disjoint_from: UBERON:0002298 ! brainstem relationship: RO:0002202 UBERON:0003080 ! develops from anterior neural tube relationship: RO:0002433 UBERON:0000955 ! contributes to morphology of brain relationship: RO:0002495 UBERON:0006240 {evidence="definitional"} ! immediate transformation of future forebrain property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/5/54/EmbryonicBrain.svg" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "forebrain" xsd:string [Term] id: UBERON:0001891 name: midbrain def: "The midbrain is the middle division of the three primary divisions of the developing chordate brain or the corresponding part of the adult brain (in vertebrates, includes a ventral part containing the cerebral peduncles and a dorsal tectum containing the corpora quadrigemina and that surrounds the aqueduct of Sylvius connecting the third and fourth ventricles)[GO]." [GO:0030901] subset: efo_slim subset: human_reference_atlas subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "MB" BROAD OMO:0003000 [BIRNLEX:1667, NIFSTD:NeuroNames_abbrevSource] synonym: "mesencephalon" RELATED OMO:0003011 [Wikipedia:Midbrain] xref: AAO:0010149 xref: BAMS:MES xref: BIRNLEX:1667 xref: BM:MB xref: BTO:0000138 xref: CALOHA:TS-0630 xref: DHBA:10648 xref: DMBA:16649 xref: EFO:0000919 xref: EHDAA2:0001162 xref: EHDAA:3694 xref: EMAPA:16974 xref: EV:0100242 xref: FMA:61993 xref: HBA:9001 xref: MA:0000207 xref: MAT:0000106 xref: MBA:313 xref: MESH:D008636 xref: MIAA:0000106 xref: NCIT:C12510 xref: neuronames:462 {source="BIRNLEX:1667"} xref: RETIRED_EHDAA2:0001104 xref: SCTID:279099009 xref: TAO:0000128 xref: UMLS:C0025462 {source="BIRNLEX:1667", source="ncithesaurus:Mesencephalon"} xref: VHOG:0000069 xref: Wikipedia:Midbrain xref: XAO:0000014 xref: ZFA:0000128 is_a: UBERON:0002616 ! regional part of brain is_a: UBERON:0004121 ! ectoderm-derived structure is_a: UBERON:0010314 ! structure with developmental contribution from neural crest relationship: RO:0002254 UBERON:0003849 {evidence="definitional"} ! has developmental contribution from mesencephalic neural crest relationship: RO:0002433 UBERON:0000955 ! contributes to morphology of brain relationship: RO:0002495 UBERON:0009616 {source="Bgee:AN"} ! immediate transformation of presumptive midbrain property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/f/f9/Human_brain_inferior_view_description.JPG" xsd:anyURI property_value: IAO:0000116 "developmental relationships need revised" xsd:string property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "midbrain" xsd:string [Term] id: UBERON:0001892 name: rhombomere def: "A segment of the developing hindbrain[ZFA]. In the vertebrate embryo, a rhombomere is a transiently divided segment of the developing neural tube, within the hindbrain region (a neuromere) in the area that will eventually become the rhombencephalon. The rhombomeres appear as a series of slightly constricted swellings in the neural tube, caudal to the cephalic flexure.[WP]." [Wikipedia:Rhombomere, ZFIN:curator] subset: efo_slim subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "future rhombencephalon" RELATED [MIAA:0000272] synonym: "hindbrain neuromere" EXACT [] synonym: "hindbrain neuromeres" EXACT OMO:0003004 [DHBA:HNM] synonym: "hindbrain segment" BROAD [ZFA:0001064] synonym: "rhombomere" EXACT [] synonym: "rhombomeres" RELATED OMO:0003004 [VHOG:0000672] synonym: "segment of hindbrain" BROAD [ZFA:0001064] xref: DHBA:12664 xref: EFO:0003617 xref: EMAPA:16148 xref: FMA:295666 xref: MAT:0000272 xref: MIAA:0000272 xref: RETIRED_EHDAA2:0000669 xref: TAO:0001064 xref: VHOG:0000672 xref: Wikipedia:Rhombomere xref: XAO:0004079 xref: ZFA:0001064 is_a: UBERON:0004731 ! neuromere intersection_of: UBERON:0004731 ! neuromere intersection_of: BFO:0000050 UBERON:0007277 ! part of presumptive hindbrain relationship: BFO:0000050 UBERON:0007277 ! part of presumptive hindbrain property_value: skos:prefLabel "rhombomere" xsd:string [Term] id: UBERON:0001893 name: telencephalon def: "Part of the forebrain consisting of paired olfactory bulbs and cerebral hemispheres." [AAO:0010479, XAO:0000012] subset: efo_slim subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "cerebrum" EXACT [BTO:0000239, EMAPA:16910, FMA:62000, https://github.com/obophenotype/uberon/issues/1208, Wikipedia:Talk\:Cerebrum/Archive_1] synonym: "endbrain" EXACT [neuronames:31, Swanson:2004] synonym: "supratentorial region" BROAD [Wikipedia:Tentorium_cerebelli] xref: AAO:0010479 xref: BAMS:CB xref: BAMS:CH xref: BAMS:IV xref: BAMS:Tel xref: BIRNLEX:1115 xref: BM:Tel xref: BTO:0000239 xref: CALOHA:TS-1018 xref: DHBA:10158 xref: EFO:0000912 xref: EHDAA2:0001982 xref: EMAPA:16910 xref: EV:0100165 xref: FMA:62000 xref: GAID:621 xref: HBA:4007 xref: MA:0000183 xref: MAT:0000421 xref: MBA:567 xref: MESH:D013687 xref: MIAA:0000421 xref: neuronames:31 {source="BIRNLEX:1115"} xref: PBA:128011350 xref: SCTID:263353005 xref: TAO:0000079 xref: UMLS:C0039452 {source="BIRNLEX:1115"} xref: VHOG:0000283 xref: Wikipedia:Telencephalon xref: XAO:0000012 xref: ZFA:0000079 is_a: UBERON:0002616 ! regional part of brain is_a: UBERON:0004121 ! ectoderm-derived structure relationship: BFO:0000050 UBERON:0001890 ! part of forebrain relationship: RO:0002495 UBERON:0014371 {source="Bgee:AN"} ! immediate transformation of future telencephalon property_value: skos:prefLabel "telencephalon" xsd:string [Term] id: UBERON:0001894 name: diencephalon def: "The division of the forebrain that develops from the foremost primary cerebral vesicle." [Wikipedia:Diencephalon] subset: efo_slim subset: human_reference_atlas subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "between brain" EXACT [] synonym: "betweenbrain" RELATED [BTO:0000342] synonym: "DiE" BROAD OMO:0003000 [BIRNLEX:1503, NIFSTD:NeuroNames_abbrevSource] synonym: "diencephalon" RELATED OMO:0003011 [Wikipedia:Diencephalon] synonym: "interbrain" EXACT [Swanson:2004] synonym: "mature diencephalon" EXACT [FMA:62001] synonym: "thalamencephalon" EXACT [MGI:anna] xref: AAO:0010481 xref: BAMS:DI xref: BAMS:Di xref: BAMS:DiE xref: BAMS:IB xref: BAMS:Zh. xref: BIRNLEX:1503 xref: BM:Die xref: BTO:0000342 xref: CALOHA:TS-0199 xref: DHBA:10389 xref: DMBA:16308 xref: EFO:0000911 xref: EHDAA2:0000385 xref: EHDAA:1969 xref: EHDAA:2645 xref: EHDAA:3472 xref: EMAPA:16896 xref: EV:0100194 xref: FMA:62001 xref: GAID:618 xref: HBA:4391 xref: MA:0000171 xref: MAT:0000420 xref: MBA:1129 xref: MESH:D004027 xref: MIAA:0000420 xref: NCIT:C12456 xref: neuronames:288 {source="BIRNLEX:1503"} xref: PBA:128013010 xref: SCTID:279328001 xref: TAO:0000101 xref: UMLS:C0012144 {source="ncithesaurus:Diencephalon", source="BIRNLEX:1503"} xref: VHOG:0000318 xref: Wikipedia:Diencephalon xref: XAO:0000013 xref: ZFA:0000101 is_a: UBERON:0002616 ! regional part of brain is_a: UBERON:0004121 ! ectoderm-derived structure is_a: UBERON:0010314 ! structure with developmental contribution from neural crest relationship: BFO:0000050 UBERON:0001890 ! part of forebrain relationship: RO:0002254 UBERON:0003851 {evidence="definitional"} ! has developmental contribution from diencephalon neural crest relationship: RO:0002433 UBERON:0001890 ! contributes to morphology of forebrain relationship: RO:0002495 UBERON:0006222 {evidence="definitional"} ! immediate transformation of future diencephalon property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/5/54/EmbryonicBrain.svg" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "diencephalon" xsd:string [Term] id: UBERON:0001895 name: metencephalon def: "Rostral segment of the hindbrain that has as its parts the pons (where present) and the cerebellum[WP,modified]." [https://github.com/obophenotype/uberon/issues/300, Wikipedia:Metencephalon] comment: the terms metencephalon and myelencephalon are only meaningful in mammals and birds[Neuroanatomy of the Zebrafish Brain]. In zebrafish, with the exception of the cerebellum, the ventral remainder of the metencephalon can be separated only arbitrarily from the more caudal myelencephalic portion of the medulla oblongata and thus these are not distinguished in ZFA[ZFA]. subset: pheno_slim subset: uberon_slim synonym: "epencephalon" BROAD INCONSISTENT [ncithesaurus:Epencephalon] synonym: "epencephalon-2" EXACT [FMA:62003] xref: BAMS:Met xref: BIRNLEX:965 xref: BTO:0000673 xref: CALOHA:TS-2029 xref: DHBA:10655 xref: EHDAA2:0001149 xref: EHDAA:5498 xref: EMAPA:17071 xref: FMA:62003 xref: GAID:594 xref: HBA:4833 xref: MA:0000197 xref: MESH:D020540 xref: NCIT:C32741 xref: neuronames:543 {source="BIRNLEX:965"} xref: UMLS:C0376353 {source="BIRNLEX:965"} xref: UMLS:C1516904 {source="ncithesaurus:Epencephalon"} xref: VHOG:0000741 xref: Wikipedia:Metencephalon is_a: UBERON:0004121 ! ectoderm-derived structure is_a: UBERON:0004733 ! segmental subdivision of hindbrain relationship: RO:0002433 UBERON:0002028 ! contributes to morphology of hindbrain relationship: RO:0002495 UBERON:0010092 {evidence="definitional"} ! immediate transformation of future metencephalon property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/5/54/EmbryonicBrain.svg" xsd:anyURI property_value: skos:prefLabel "metencephalon" xsd:string property_value: terms:contributor https://orcid.org/0000-0002-6601-2165 [Term] id: UBERON:0001896 name: medulla oblongata def: "Organ component of neuraxis that has as its parts the medullary reticular formation, inferior olivary complex and cochlear nuclear complex, among other structures[FMA]. The medulla oblongata lies directly above the spinal cord and controls vital autonomic functions such as digestion, breathing and the control of heart rate[GO]." [FMA:62004, GO:0021550, Wikipedia:Bone_marrow_of_ovary_oblongata] subset: efo_slim subset: human_reference_atlas subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "bulb" BROAD [] synonym: "bulbus" EXACT OMO:0003011 [FMA:62004, FMA:TA] synonym: "medulla" BROAD [ABA:MY] synonym: "medulla oblonzata" RELATED OMO:0003011 [Wikipedia:Medulla_oblongata] synonym: "metepencephalon" RELATED [FMA:62004] xref: AAO:0010486 xref: BAMS:Md xref: BAMS:MY xref: BIRNLEX:957 xref: BM:Me xref: BTO:0000041 xref: CALOHA:TS-0607 xref: DMBA:17352 xref: EFO:0000924 xref: EHDAA2:0001088 xref: EHDAA:7588 xref: EMAPA:17550 xref: EV:0100275 xref: FMA:62004 xref: GAID:590 xref: MA:0000206 xref: MAT:0000111 xref: MAT:0000367 xref: MBA:354 xref: MESH:D008526 xref: MIAA:0000111 xref: NCIT:C12442 xref: neuronames:698 {source="BIRNLEX:957"} xref: SCTID:279104005 xref: TAO:0000545 xref: UMLS:C0025148 {source="ncithesaurus:Medulla_Oblongata", source="BIRNLEX:957"} xref: UMLS:C1269575 {source="BIRNLEX:957"} xref: VHOG:0000181 xref: Wikipedia:Bone_marrow_of_ovary_oblongata xref: XAO:0003100 xref: ZFA:0000545 is_a: UBERON:0000064 ! organ part relationship: BFO:0000050 UBERON:0002298 ! part of brainstem relationship: BFO:0000050 UBERON:0005290 ! part of myelencephalon relationship: RO:0002215 GO:0002027 ! capable of regulation of heart rate relationship: RO:0002215 GO:0043576 ! capable of regulation of respiratory gaseous exchange relationship: RO:0002215 GO:0044058 ! capable of regulation of digestive system process property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/6/6b/Illu_pituitary_pineal_glands.jpg" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "medulla oblongata" xsd:string [Term] id: UBERON:0001897 name: dorsal plus ventral thalamus def: "Subcortical brain region consisting of paired gray matter bodies in the dorsal diencephalon and forming part of the lateral wall of the third ventricle of the brain. The thalamus represents the major portion of the diencephalon and is commonly divided into cellular aggregates known as nuclear groups.(MeSH). The dorsal topographic division of the interbrain. The macrodissected adult human thalamus was clearly illustrated by Vesalius in 1543 and the term as defined here was introduced by His in 1893. It includes the traditional epithalamus, dorsal thalamus, and ventral thalamus of Herrick (1910, pp. 494, 498). Also see Kuhlenbeck (1927, Ch. 9) and Jones (1985, p. 87)." [BIRNLEX:954] subset: efo_slim subset: human_reference_atlas subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "Th" BROAD OMO:0003000 [BIRNLEX:954, NIFSTD:NeuroNames_abbrevSource, PMID:23375746] synonym: "thalamencephalon" RELATED OMO:0003011 [NeuroNames:300] synonym: "thalami" RELATED OMO:0003004 [VHOG:0000657] synonym: "thalamus" BROAD [FMA:62007, MA:0000179] synonym: "thalamus opticus" RELATED OMO:0003011 [NeuroNames:300] synonym: "wider thalamus" EXACT [PMCID:PMC3345571] xref: AAO:0010483 xref: BAMS:TH xref: BAMS:Th xref: BIRNLEX:954 xref: BTO:0001365 xref: CALOHA:TS-1031 xref: DHBA:10390 xref: DMBA:16376 xref: EFO:0000910 xref: EMAPA:17540 xref: EV:0100195 xref: GAID:656 xref: galen:Thalamus xref: HBA:4392 xref: MA:0000179 xref: MAT:0000109 xref: MBA:549 xref: MIAA:0000109 xref: NCIT:C12459 xref: neuronames:300 {source="BIRNLEX:954"} xref: PBA:128013014 xref: SCTID:244433007 xref: TAO:0001215 xref: UMLS:C0039729 {source="BIRNLEX:954", source="ncithesaurus:Thalamus"} xref: VHOG:0000657 xref: Wikipedia:Thalamus xref: ZFA:0001215 is_a: UBERON:0002616 ! regional part of brain is_a: UBERON:0015212 ! lateral structure relationship: BSPO:0000126 UBERON:0010225 {source="FMA-abduced-lr"} ! thalamic complex relationship: RO:0002433 UBERON:0001894 ! contributes to morphology of diencephalon property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/c/ce/Brain_chrischan_thalamus.jpg" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "dorsal plus ventral thalamus" xsd:string [Term] id: UBERON:0001898 name: hypothalamus def: "A specialized brain region of the ventral diencephalon arising near the end of the segmentation period; the embryonic hypothalamic region will give rise to the posterior pituitary gland as well as a number of brain nuclei. [ZFA]. One of the most important functions of the hypothalamus is to link the nervous system to the endocrine system via the pituitary gland (hypophysis).[Wikipedia]." [Wikipedia:Hypothalamus, ZFIN:curator] subset: efo_slim subset: human_reference_atlas subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "Hy" BROAD OMO:0003000 [BIRNLEX:734, NIFSTD:NeuroNames_abbrevSource] synonym: "hypothalamus" RELATED OMO:0003011 [Wikipedia:Hypothalamus] synonym: "preoptico-hypothalamic area" EXACT [] synonym: "preoptico-hypothalamic region" EXACT [] xref: AAO:0010484 xref: BAMS:HY xref: BAMS:Hy xref: BIRNLEX:734 xref: BM:Die-Hy xref: BTO:0000614 xref: CALOHA:TS-0469 xref: DHBA:10467 xref: EFO:0000107 xref: EHDAA2:0000802 xref: EHDAA:5446 xref: EMAPA:17536 xref: EV:0100225 xref: FMA:62008 xref: GAID:460 xref: galen:Hypothalamus xref: HBA:4540 xref: MA:0000173 xref: MAT:0000112 xref: MBA:1097 xref: MESH:D007031 xref: MIAA:0000112 xref: NCIT:C12458 xref: neuronames:292 {source="BIRNLEX:734"} xref: SCTID:264483005 xref: TAO:0000032 xref: UMLS:C0020663 {source="BIRNLEX:734", source="ncithesaurus:Hypothalamus"} xref: VHOG:0000179 xref: Wikipedia:Hypothalamus xref: XAO:0004070 xref: ZFA:0000032 is_a: UBERON:0002616 ! regional part of brain relationship: BFO:0000050 UBERON:0000349 ! part of limbic system relationship: BFO:0000050 UBERON:0010225 ! part of thalamic complex relationship: RO:0002215 GO:0046883 {source="WP"} ! capable of regulation of hormone secretion relationship: RO:0002433 UBERON:0001894 ! contributes to morphology of diencephalon property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/9/9f/LocationOfHypothalamus.jpg" xsd:anyURI property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/brain-female/v1.4/assets/3d-allen-f-brain.glb" xsd:anyURI property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/brain-male/v1.4/assets/3d-allen-m-brain.glb" xsd:anyURI property_value: RO:0002175 NCBITaxon:117569 {source="Ariens, p. 1192"} property_value: RO:0002175 NCBITaxon:7742 property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "hypothalamus" xsd:string [Term] id: UBERON:0001899 name: epithalamus def: "Most dorsal part of the thalamus, comprising the pineal gland and habenular nuclei in most vertebrates. In a few vertebrates, it also includes the parietal eye. (Butler and Hodos, Comparative Vertebrate Neuroanatomy, 2nd ed, 2005, pg. 345-346." [BIRNLEX:1710] subset: efo_slim subset: human_reference_atlas subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "epithalamus" RELATED OMO:0003011 [Wikipedia:Epithalamus] synonym: "ETh" BROAD OMO:0003000 [BIRNLEX:1710, NIFSTD:NeuroNames_abbrevSource] xref: AAO:0010482 xref: BAMS:EPI xref: BAMS:Epi xref: BAMS:EpT xref: BAMS:ETh xref: BIRNLEX:1710 xref: BM:Die-Epi xref: BTO:0000175 xref: CALOHA:TS-2060 xref: DHBA:10451 xref: EFO:0000918 xref: EHDAA2:0000448 xref: EHDAA:5433 xref: EMAPA:17532 xref: EV:0100220 xref: FMA:62009 xref: GAID:455 xref: HBA:4520 xref: MA:0000172 xref: MAT:0000422 xref: MBA:958 xref: MESH:D019261 xref: MIAA:0000422 xref: NCIT:C12457 xref: neuronames:292 {source="BIRNLEX:1710"} xref: PBA:128013147 xref: SCTID:281487003 xref: TAO:0000509 xref: UMLS:C0152361 {source="BIRNLEX:1710", source="ncithesaurus:Epithalamus"} xref: VHOG:0000178 xref: Wikipedia:Epithalamus xref: ZFA:0000509 is_a: UBERON:0002616 ! regional part of brain relationship: BFO:0000050 UBERON:0001897 ! part of dorsal plus ventral thalamus relationship: RO:0002433 UBERON:0001894 ! contributes to morphology of diencephalon property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/c/cb/Epithalamus.png" xsd:anyURI property_value: RO:0002175 NCBITaxon:7742 property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "epithalamus" xsd:string [Term] id: UBERON:0001900 name: ventral thalamus def: "Anterior part of the diencephalon that lies between the dorsal thalamus, hypothalamus, and tegmentum of the mesencephalon, including subthalamic nucleus, zona incerta, the fields of Forel, and the nucleus of ansa lenticularis[GO, modified]." [GO:0021539] comment: Some sources treat the subthalamus as distinct from the thalamus, separated by the zona limitans intrathalamica. In MA, the ventral thalamus is part of the thalamus. Butler Hodos who identify a dorsal to ventral sequence consisting of epithalamus, dorsal thalamus, ventral thalamus and hypothalamus. We solve this by considering dorsal and ventral thalamus distinct, and the label thalamus as being ambiguous w.r.t thalamus proper (dorsal thalamus) or wider thalamus (dorsal plus ventral) subset: human_reference_atlas subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "perithalamus" RELATED [Wikipedia:Thalamus] synonym: "prethalamus" RELATED DEVELOPMENTAL [Wikipedia:Thalamus] synonym: "SbTh" BROAD OMO:0003000 [BIRNLEX:708, NIFSTD:NeuroNames_abbrevSource] synonym: "subthalamic region" EXACT [BIRNLEX:708, FMA:62010] synonym: "subthalamus" EXACT [BIRNLEX:708, Wikipedia:Thalamus] synonym: "thalamus ventralis" EXACT OMO:0003011 [BIRNLEX:708] synonym: "ventral thalamus" EXACT [GO:0021539, MA:0000181] xref: BAMS:SbTh xref: BAMS:Ventral_thalamus xref: BAMS:VNT xref: BAMS:VT xref: BIRNLEX:708 xref: BM:Die-VTh xref: CALOHA:TS-2048 xref: DHBA:10461 xref: DMBA:16310 xref: EHDAA2:0004470 xref: EMAPA:35915 xref: EV:0100223 xref: FMA:62010 xref: GAID:653 xref: HBA:4504 xref: MA:0000181 xref: MESH:D020530 xref: NCIT:C52731 xref: neuronames:434 {source="BIRNLEX:708"} xref: SCTID:279332007 xref: TAO:0000458 xref: UMLS:C0152349 {source="BIRNLEX:708", source="ncithesaurus:Ventral_Thalamus"} xref: Wikipedia:Subthalamus xref: ZFA:0000458 is_a: UBERON:0002616 ! regional part of brain relationship: BFO:0000050 UBERON:0001897 ! part of dorsal plus ventral thalamus relationship: RO:0002433 UBERON:0001894 ! contributes to morphology of diencephalon property_value: RO:0002175 NCBITaxon:117569 {source="Ariens, p. 1192"} property_value: RO:0002175 NCBITaxon:7742 property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "ventral thalamus" xsd:string [Term] id: UBERON:0001901 name: epithelium of trachea def: "The epithelial lining of the trachea which contains numerous ciliated cells." [ISBN:0-397-51047-0, MGI:cwg, MP:0002285] subset: human_reference_atlas subset: pheno_slim synonym: "epithelial tissue of trachea" EXACT [OBOL:automatic] synonym: "epithelial tissue of windpipe" EXACT [OBOL:automatic] synonym: "epithelium of windpipe" EXACT [OBOL:automatic] synonym: "trachea epithelial tissue" EXACT [OBOL:automatic] synonym: "trachea epithelium" EXACT [] synonym: "tracheal epithelium" EXACT [] synonym: "windpipe epithelial tissue" EXACT [OBOL:automatic] synonym: "windpipe epithelium" EXACT [OBOL:automatic] xref: BTO:0001389 xref: CALOHA:TS-1061 xref: EHDAA2:0002069 xref: EHDAA:5007 xref: EMAPA:16855 xref: EMAPA:18409 xref: FMA:62015 xref: MA:0001862 xref: NCIT:C33797 xref: UMLS:C1179002 {source="ncithesaurus:Tracheal_Epithelium"} xref: VHOG:0001045 is_a: UBERON:0005911 ! endo-epithelium is_a: UBERON:0008397 ! tracheobronchial epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: BFO:0000050 UBERON:0003126 ! part of trachea relationship: BFO:0000050 UBERON:0003126 ! part of trachea relationship: RO:0002202 UBERON:0003258 ! develops from endoderm of foregut relationship: RO:0002433 UBERON:0003126 ! contributes to morphology of trachea property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "epithelium of trachea" xsd:string [Term] id: UBERON:0001902 name: epithelium of small intestine def: "An epithelium that is part of a small intestine [Automatically generated definition]." [OBOL:automatic] subset: vertebrate_core synonym: "epithelial tissue of small bowel" EXACT [OBOL:automatic] synonym: "epithelial tissue of small intestine" EXACT [OBOL:automatic] synonym: "epithelium of small bowel" EXACT [OBOL:automatic] synonym: "mid intestine epithelium" EXACT [ZFA:0005127] synonym: "small bowel epithelial tissue" EXACT [OBOL:automatic] synonym: "small bowel epithelium" EXACT [OBOL:automatic] synonym: "small intestinal epithelium" EXACT [] synonym: "small intestine epithelial tissue" EXACT [OBOL:automatic] synonym: "small intestine epithelium" EXACT [] xref: BTO:0001258 xref: CALOHA:TS-2104 xref: EMAPA:35778 xref: FMA:62017 xref: MA:0001553 xref: SCTID:45480009 xref: TAO:0005127 xref: ZFA:0005127 is_a: UBERON:0001277 ! intestinal epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: BFO:0000050 UBERON:0002108 ! part of small intestine relationship: BFO:0000050 UBERON:0001204 ! part of mucosa of small intestine relationship: BFO:0000051 CL:0000164 {source="FMA"} ! has part enteroendocrine cell property_value: skos:prefLabel "epithelium of small intestine" xsd:string [Term] id: UBERON:0001905 name: pineal body def: "A midline, cone like structure located in the dorso-caudal roof of the 3rd ventricle, attached by peduncles to the habenular and posterior commissures. The stalk contains nerve fibers, blood vessels, connective tissue and parenchymal cells (Paxinos, The Rat Central Nervous System, 2nd ed, pg 399)." [BIRNLEX:1184] subset: efo_slim subset: human_reference_atlas subset: organ_slim subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "conarium" RELATED [BIRNLEX:1184] synonym: "corpus pineale" EXACT [] synonym: "epiphysis" RELATED INCONSISTENT [ZFA:0000019] synonym: "epiphysis cerebri" RELATED [Wikipedia:Epiphysis_cerebri] synonym: "frontal organ" RELATED [VHOG:0000051] synonym: "glandula pinealis" EXACT OMO:0003011 [FMA:62033, FMA:TA] synonym: "Pi" BROAD OMO:0003000 [BIRNLEX:1184, NIFSTD:NeuroNames_abbrevSource] synonym: "pineal" RELATED [VHOG:0000051] synonym: "pineal gland" EXACT [FMA:62033] synonym: "pineal gland (Galen)" RELATED [NeuroNames:297] synonym: "pineal organ" EXACT [ZFA:0000019] synonym: "stirnorgan" RELATED [VHOG:0000051] xref: AAO:0010549 xref: BAMS:Pi xref: BAMS:PIN xref: BIRNLEX:1184 xref: BM:P xref: BTO:0001067 xref: CALOHA:TS-0789 xref: DHBA:10460 xref: EFO:0000865 xref: EHDAA2:0001466 xref: EHDAA:7523 xref: EMAPA:18778 xref: EV:0100131 xref: EV:0100221 xref: FMA:62033 xref: GAID:453 xref: galen:PinealGland xref: HBA:4532 xref: MA:0000175 xref: MAT:0000448 xref: MBA:953 xref: MESH:D010870 xref: NCIT:C12398 xref: neuronames:297 {source="BIRNLEX:1184"} xref: NLXANAT:1010009 xref: SCTID:181126002 xref: TAO:0000019 xref: UMLS:C0031939 {source="ncithesaurus:Pineal_Gland", source="BIRNLEX:1184"} xref: VHOG:0000051 xref: Wikipedia:Pineal_gland xref: XAO:0000160 xref: ZFA:0000019 is_a: UBERON:0003296 ! gland of diencephalon is_a: UBERON:0010134 {source="MA"} ! secretory circumventricular organ relationship: BFO:0000050 UBERON:0015238 {source="ZFA", source="various"} ! part of pineal complex relationship: BFO:0000051 CL:0000652 ! has part pinealocyte relationship: BFO:0000051 CL:0002220 ! has part interstitial cell of pineal gland relationship: RO:0002215 GO:0030187 {comment="EDITOR_NOTE add secretion"} ! capable of melatonin biosynthetic process relationship: RO:0002433 UBERON:0001899 ! contributes to morphology of epithalamus property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/6/6b/Illu_pituitary_pineal_glands.jpg" xsd:anyURI property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/brain-female/v1.4/assets/3d-allen-f-brain.glb" xsd:anyURI property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/brain-male/v1.4/assets/3d-allen-m-brain.glb" xsd:anyURI property_value: RO:0002175 NCBITaxon:117569 {source="Hardisty, p. 310"} property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "pineal body" xsd:string [Term] id: UBERON:0001906 name: subthalamic nucleus def: "The subthalamic nucleus is the lens-shaped nucleus located in the ventral part of the subthalamus on the inner aspect of the internal capsule that is concerned with the integration of somatic motor function[GO]." [GO:0021763] subset: efo_slim subset: human_reference_atlas subset: pheno_slim subset: uberon_slim synonym: "body of Forel" EXACT [] synonym: "body of Luys" EXACT [] synonym: "corpus Luysi" RELATED [Wikipedia:Subthalamic_nucleus] synonym: "corpus subthalamicum" RELATED OMO:0003011 [Wikipedia:Subthalamic_nucleus] synonym: "Luy's body" RELATED [Wikipedia:Subthalamic_nucleus] synonym: "Luys' body" RELATED [BTO:0002252] synonym: "Luys' nucleus" EXACT [] synonym: "nucleus of corpus luysii" EXACT [] synonym: "nucleus of Luys" EXACT [Wikipedia:Subthalamic_nucleus] synonym: "nucleus subthalamicus" EXACT OMO:0003011 [BTO:0002252, Wikipedia:Subthalamic_nucleus] synonym: "subthalamic nucleus (of Luys)" EXACT [] synonym: "subthalamic nucleus of Luys" RELATED [Wikipedia:Subthalamic_nucleus] xref: BAMS:STh xref: BAMS:STN xref: BAMS:SUB xref: BM:Die-Sb xref: BTO:0002252 xref: CALOHA:TS-1154 xref: DHBA:10466 xref: EFO:0001392 xref: EMAPA:35839 xref: EV:0100224 xref: FMA:62035 xref: GAID:655 xref: HBA:4518 xref: MA:0000877 xref: MBA:470 xref: MESH:D020531 xref: NCIT:C12454 xref: neuronames:435 xref: NLXANAT:1010002 xref: SCTID:361575000 xref: UMLS:C0152355 {source="ncithesaurus:Subthalamic_Nucleus"} xref: Wikipedia:Subthalamic_nucleus is_a: UBERON:0015233 ! nucleus of dorsal thalamus is_a: UBERON:0015234 ! nucleus of ventral thalamus relationship: BFO:0000050 UBERON:0002776 ! part of ventral nuclear group relationship: RO:0002433 UBERON:0001900 ! contributes to morphology of ventral thalamus property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/3/33/Basal-ganglia-coronal-sections-large.png" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "subthalamic nucleus" xsd:string [Term] id: UBERON:0001907 name: zona incerta def: "The zona incerta is a horizontally elongated region of gray matter cells in the subthalamus below the thalamus. Its connections project extensively over the brain from the cerebral cortex down into the spinal cord. Its function is unknown though several have been proposed related to 'limbic-motor integration' such as controlling visceral activity and pain; gating sensory input and synchronizing cortical and subcortical brain rhythms. Its dysfunction may play a role in central pain syndrome. It is also been identified as a promising deep brain stimulation therapy target for treating Parkinsons Disease. Its existence was first described by Auguste Forel in 1877 as a 'region of which nothing certain can be said'. A hundred and thirty years later in 2007, Nadia Urbain and Martin Deschênes of Université Laval noted that the 'zona incerta is among the least studied regions of the brain; its name does not even appear in the index of many textbooks. ' [WP,unvetted]." [Wikipedia:Zona_incerta] subset: human_reference_atlas subset: uberon_slim synonym: "nucleus of the zona incerta" RELATED [BAMS:ZI] synonym: "zona incerta proper" RELATED [BAMS:ZI] xref: BAMS:ZI xref: BM:Die-VTh-ZI xref: BTO:0003146 xref: DHBA:10463 xref: EMAPA:35930 xref: FMA:62038 xref: HBA:4507 xref: MA:0000878 xref: MBA:797 xref: neuronames:438 xref: SCTID:369186007 xref: Wikipedia:Zona_incerta is_a: UBERON:0015234 ! nucleus of ventral thalamus property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "zona incerta" xsd:string [Term] id: UBERON:0001908 name: optic tract def: "Diencephalic white matter (tract) which is comprised of retinal ganglion cell axons after which they have passed through the optic chiasm[ZFA]. Predominantly white matter structure found in diencephalon consisting of fibers originating in the retina. The optic tract is considered to extend from the point of the optic chiasm and terminates largely, although not exclusively, in the lateral geniculate complex. Other fibers end in the superior colliculus and other structures in the diencephalon, midbrain and brainstem (MM)[NIF]." [NIFSTD, Wikipedia:Optic_tract, ZFIN:curator] subset: human_reference_atlas subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "optic lemniscus" EXACT [] synonym: "optic tracts" RELATED OMO:0003004 [ZFA:0000252] synonym: "tractus optici" RELATED OMO:0003011 [NeuroNames:460] synonym: "tractus opticus" RELATED OMO:0003011 [Wikipedia:Optic_tract] synonym: "visual pathway" RELATED [GAID:735] xref: BAMS:opt xref: BIRNLEX:1684 xref: BM:Tel-OT xref: DHBA:10589 xref: DMBA:17785 xref: EMAPA:35617 xref: FMA:62046 xref: GAID:735 xref: HBA:9309 xref: MA:0001099 xref: MBA:125 xref: MESH:D014795 xref: NCIT:C33218 xref: neuronames:460 {source="BIRNLEX:1684"} xref: SCTID:280952003 xref: TAO:0000252 xref: UMLS:C0152405 {source="ncithesaurus:Optic_Tract", source="BIRNLEX:1684"} xref: VHOG:0001164 xref: Wikipedia:Optic_tract xref: XAO:0004101 xref: ZFA:0000252 is_a: UBERON:0011591 ! tract of diencephalon relationship: BFO:0000050 UBERON:0002104 ! part of visual system relationship: BFO:0000050 UBERON:0003931 ! part of diencephalic white matter relationship: extends_fibers_into UBERON:0000941 ! cranial nerve II relationship: extends_fibers_into UBERON:0000959 ! optic chiasma relationship: RO:0002134 UBERON:0000966 ! innervates retina relationship: RO:0002433 UBERON:0003544 ! contributes to morphology of brain white matter property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/f/f6/Gray773.png" xsd:anyURI property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/brain-female/v1.4/assets/3d-allen-f-brain.glb" xsd:anyURI property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/brain-male/v1.4/assets/3d-allen-m-brain.glb" xsd:anyURI property_value: IAO:0000116 "relationships need checking by expert. NIF and ZFA both state part of diencepahalon; MA says part of optic nerve II. in uberon, CNS and PNS are spatially disjoint, and axon tracts are part of the CNS so we make the relationship to CNII 'continuous_with'" xsd:string property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "optic tract" xsd:string [Term] id: UBERON:0001911 name: mammary gland def: "A specialized accessory gland of the skin of mammals that secretes milk. The gland is typically only developed in females, and regresses in males." [BTO:0000817, http://orcid.org/0000-0002-6601-2165, Wikipedia:Mammary_gland] subset: efo_slim subset: human_reference_atlas subset: organ_slim subset: pheno_slim subset: uberon_slim synonym: "Brustdruese" RELATED [BTO:0000817] synonym: "dug" RELATED [Wikipedia:Mammary_gland] synonym: "glandula mammaria" EXACT OMO:0003011 [FMA:57983, FMA:TA] synonym: "glandula mammaria" RELATED OMO:0003011 [Wikipedia:Mammary_gland] synonym: "lactiferous gland" EXACT [FMA:62088] synonym: "lobe of breast" NARROW [] synonym: "lobe of mammary gland" RELATED [FMA:62088] synonym: "mamma" RELATED [BTO:0000817] synonym: "mammae" RELATED OMO:0003004 [] synonym: "milk patch" NARROW [NCBITaxon:9255] xref: BTO:0000817 xref: CALOHA:TS-0595 xref: EFO:0000854 xref: EMAPA:17759 xref: EV:0100125 xref: FMA:286452 xref: MA:0000145 xref: MAT:0000073 xref: MESH:D008321 xref: MIAA:0000073 xref: NCIT:C12367 xref: SCTID:361720005 xref: UMLS:C0929301 {source="ncithesaurus:Mammary_Gland"} xref: VHOG:0000398 xref: Wikipedia:Mammary_gland is_a: UBERON:0004121 ! ectoderm-derived structure is_a: UBERON:0019319 ! exocrine gland of integumental system intersection_of: UBERON:0002530 ! gland intersection_of: RO:0002215 GO:0007595 ! capable of lactation relationship: RO:0002202 UBERON:0005333 ! develops from mammary bud relationship: RO:0002215 GO:0007595 ! capable of lactation relationship: RO:0003000 UBERON:0001913 ! produces milk property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/6/64/Illu_breast_anatomy.jpg" xsd:anyURI property_value: IAO:0000116 "Originally this was classified as a female reproductive structure, as it was in the MP in 2011" xsd:string property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001912 name: lobule of mammary gland def: "Organ component of the mammary gland which consists of an aggregate of mammary alveoli that communicate with a lobular lactiferous duct.[FMA]." [FMA:62090] subset: pheno_slim subset: uberon_slim synonym: "acinus of mammary gland" EXACT [FMA:62090] synonym: "lactiferous acinus" EXACT [FMA:62090] synonym: "lactiferous gland lobule" EXACT [FMA:62090] synonym: "lactiferous lobule" EXACT [FMA:62090] synonym: "lobule of lactiferous gland" EXACT [FMA:62090] synonym: "lobule of mammary gland" EXACT [FMA:62090] synonym: "mammary acinus" EXACT [FMA:62090] synonym: "mammary gland lobule" EXACT [MA:0000793] xref: EMAPA:36634 xref: FMA:62090 xref: MA:0000793 is_a: UBERON:0009911 {source="FMA"} ! lobule relationship: BFO:0000050 UBERON:0001911 ! part of mammary gland relationship: RO:0002433 UBERON:0001911 ! contributes to morphology of mammary gland property_value: IAO:0000116 "TODO - ensure correct terminology for lobes/lobules. In mouse there are no distinct lobes (ISBN:0123813611), here lobule appears to be synonymous with acinus" xsd:string [Term] id: UBERON:0001913 name: milk def: "An emulsion of fat globules within a fluid that is secreted by the mammary gland during lactation." [http://orcid.org/0000-0002-6601-2165] subset: pheno_slim subset: uberon_slim synonym: "mammary gland milk" EXACT [] xref: BTO:0000868 xref: CALOHA:TS-0636 xref: EMAPA:36540 xref: ENVO:02000031 xref: EV:0100126 xref: FMA:62100 xref: GAID:1230 xref: galen:Milk xref: MA:0002552 xref: MAT:0000056 xref: MESH:D008892 xref: MIAA:0000056 xref: NCIT:C13401 xref: UMLS:C1511310 {source="ncithesaurus:Breast_Fluid_or_Secretion"} xref: VHOG:0001263 xref: Wikipedia:Breast_milk is_a: BFO:0000002 is_a: UBERON:0006314 ! bodily fluid is_a: UBERON:0006539 ! mammary gland fluid/secretion relationship: BFO:0000051 CHEBI:18059 ! has part relationship: BFO:0000051 PR:000028527 ! has part casein derived peptide relationship: RO:0002353 GO:0007595 ! output of lactation property_value: IAO:0000116 "to axiomatize the different forms of mammary gland secretion an ontology of the phases of pregnancy/lactation is required. Using the existing GO def of lactation is circular." xsd:string [Term] id: UBERON:0001915 name: endothelium of capillary def: "An endothelium that is part of a capillary [Automatically generated definition]." [OBOL:automatic] synonym: "blood capillary endothelium" EXACT [OBOL:automatic] synonym: "capillary endothelium" EXACT [] synonym: "capillary vessel endothelium" EXACT [OBOL:automatic] synonym: "endothelium of blood capillary" EXACT [OBOL:automatic] synonym: "endothelium of capillary vessel" EXACT [OBOL:automatic] xref: BTO:0004954 xref: CALOHA:TS-0112 xref: EMAPA:36292 xref: FMA:62114 xref: MA:0000711 xref: NCIT:C49215 xref: UMLS:C0006904 {source="ncithesaurus:Capillary_Endothelium"} is_a: UBERON:0008339 ! microvascular endothelium intersection_of: UBERON:0001986 ! endothelium intersection_of: BFO:0000050 UBERON:0001982 ! part of capillary relationship: BFO:0000050 UBERON:0001982 ! part of capillary property_value: skos:prefLabel "endothelium of capillary" xsd:string [Term] id: UBERON:0001916 name: endothelium of arteriole def: "An endothelium that is part of an arteriole [Automatically generated definition]." [OBOL:automatic] synonym: "arteriole endothelium" EXACT [] xref: EMAPA:36286 xref: FMA:62115 xref: MA:0000705 xref: NCIT:C49192 xref: UMLS:C1179024 {source="ncithesaurus:Arteriole_Endothelium"} is_a: UBERON:0004700 ! arterial system endothelium is_a: UBERON:0008339 ! microvascular endothelium intersection_of: UBERON:0001986 ! endothelium intersection_of: BFO:0000050 UBERON:0001980 ! part of arteriole relationship: BFO:0000050 UBERON:0001980 ! part of arteriole property_value: skos:prefLabel "endothelium of arteriole" xsd:string [Term] id: UBERON:0001917 name: endothelium of artery def: "An endothelium that is part of an artery [Automatically generated definition]." [OBOL:automatic] synonym: "arterial endothelium" EXACT [] synonym: "artery endothelium" EXACT [] xref: AAO:0011013 xref: BTO:0004757 xref: EMAPA:35148 xref: FMA:62116 xref: MA:0000707 xref: NCIT:C49194 xref: UMLS:C1179025 {source="ncithesaurus:Artery_Endothelium"} xref: VHOG:0001215 xref: XAO:0000357 is_a: UBERON:0003915 ! endothelial tube is_a: UBERON:0004638 ! blood vessel endothelium is_a: UBERON:0004700 ! arterial system endothelium intersection_of: UBERON:0001986 ! endothelium intersection_of: BFO:0000050 UBERON:0001637 ! part of artery relationship: BFO:0000050 UBERON:0001637 ! part of artery property_value: skos:prefLabel "endothelium of artery" xsd:string [Term] id: UBERON:0001918 name: endothelium of venule def: "An endothelium that is part of a venule [Automatically generated definition]." [OBOL:automatic] synonym: "venule endothelium" EXACT [] xref: EMAPA:36290 xref: FMA:62117 xref: MA:0000716 xref: NCIT:C49319 xref: UMLS:C1179026 {source="ncithesaurus:Venule_Endothelium"} is_a: UBERON:0004701 ! venous system endothelium is_a: UBERON:0008339 ! microvascular endothelium intersection_of: UBERON:0001986 ! endothelium intersection_of: BFO:0000050 UBERON:0001979 ! part of venule relationship: BFO:0000050 UBERON:0001979 ! part of venule property_value: skos:prefLabel "endothelium of venule" xsd:string [Term] id: UBERON:0001919 name: endothelium of vein def: "An endothelium that is part of a vein [Automatically generated definition]." [OBOL:automatic] synonym: "vein endothelium" EXACT [] synonym: "veinous endothelium" RELATED [VHOG:0001216] synonym: "venous endothelium" EXACT [] xref: AAO:0011110 xref: BTO:0004756 xref: EMAPA:36288 xref: FMA:62118 xref: MA:0000712 xref: NCIT:C49317 xref: UMLS:C1179027 {source="ncithesaurus:Vein_Endothelium"} xref: VHOG:0001216 xref: XAO:0000358 is_a: UBERON:0004638 ! blood vessel endothelium is_a: UBERON:0004701 ! venous system endothelium intersection_of: UBERON:0001986 ! endothelium intersection_of: BFO:0000050 UBERON:0001638 ! part of vein relationship: BFO:0000050 UBERON:0001638 ! part of vein property_value: skos:prefLabel "endothelium of vein" xsd:string [Term] id: UBERON:0001926 name: lateral geniculate body def: "The group of neurons that serve as the primary processor of visual information received from the retina via the optic tract and send processed information to the visual cortex of the occipital lobe." [ISBN:0-683-40008-8, MP:0004165] subset: efo_slim subset: human_reference_atlas subset: pheno_slim subset: uberon_slim synonym: "corpus geniculatum externum" RELATED [BTO:0004367] synonym: "corpus geniculatum laterale" RELATED [BTO:0004367] synonym: "corpus geniculatum laterales" EXACT [BIRNLEX:1662] synonym: "corpus geniculatus lateralis" RELATED OMO:0003011 [NeuroNames:352] synonym: "external geniculate body" RELATED [Wikipedia:Lateral_geniculate_nucleus] synonym: "lateral geniculate complex" EXACT [] synonym: "lateral geniculate nucleus" EXACT [] synonym: "LGB" RELATED OMO:0003000 [BTO:0004367] synonym: "LGN" BROAD OMO:0003000 [BIRNLEX:1662, NIFSTD:NeuroNames_abbrevSource] synonym: "nucleus corporis geniculati lateralis" RELATED OMO:0003011 [BAMS:LG, NeuroNames:352] synonym: "nucleus geniculatus lateralis" EXACT [BIRNLEX:1662] xref: BAMS:C.gl. xref: BAMS:LG xref: BIRNLEX:1662 xref: BTO:0004366 xref: BTO:0004367 xref: DHBA:10429 xref: EFO:0001988 xref: EMAPA:35478 xref: EV:0100219 xref: FMA:62209 xref: MA:0000869 xref: NCIT:C32556 xref: neuronames:352 {source="BIRNLEX:1662"} xref: PBA:128013070 xref: SCTID:362377006 xref: UMLS:C0086526 {source="ncithesaurus:External_Geniculate_Body", source="BIRNLEX:1662"} xref: Wikipedia:Lateral_geniculate_body is_a: UBERON:0015233 ! nucleus of dorsal thalamus relationship: BFO:0000050 UBERON:0002704 {source="FMA"} ! part of metathalamus relationship: RO:0002433 UBERON:0001897 ! contributes to morphology of dorsal plus ventral thalamus property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/b/b7/Gray719.png" xsd:anyURI property_value: RO:0002175 NCBITaxon:117569 {source="Ariens, p. 1192"} property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "lateral geniculate body" xsd:string [Term] id: UBERON:0001928 name: preoptic area def: "Area of the forebrain between the anterior commissure and optic chiasm." [Wikipedia:Preoptic_area, ZFIN:curator] subset: efo_slim subset: uberon_slim subset: vertebrate_core synonym: "area hypothalamica rostralis" RELATED [BTO:0001796] synonym: "area praeoptica" RELATED [] synonym: "area preoptica" RELATED OMO:0003011 [Wikipedia:Preoptic_area] synonym: "nuclei preoptici" RELATED OMO:0003011 [NeuroNames:377] synonym: "POA" BROAD OMO:0003000 [BIRNLEX:1706, NIFSTD:NeuroNames_abbrevSource, PMID:23375746] synonym: "preoptic hypothalamic area" RELATED [BTO:0001796] synonym: "preoptic hypothalamic region" RELATED [BTO:0001796] synonym: "preoptic nuclei" EXACT [] synonym: "preoptic region" RELATED [] synonym: "preoptic region of hypothalamus" EXACT [] synonym: "regio hypothalamica anterior" RELATED [BTO:0001796] xref: BAMS:POA xref: BIRNLEX:1706 xref: BM:Die-Hy-POA xref: BTO:0001796 xref: CALOHA:TS-0822 xref: DMBA:15577 xref: EFO:0002523 xref: EMAPA:36655 xref: FMA:62313 xref: GAID:644 xref: HBA:4541 xref: MESH:D011301 xref: neuronames:377 {source="BIRNLEX:1706"} xref: SCTID:362382004 xref: TAO:0000470 xref: UMLS:C0033063 {source="BIRNLEX:1706"} xref: UMLS:C1284641 {source="BIRNLEX:1706"} xref: Wikipedia:Preoptic_area xref: ZFA:0000470 is_a: UBERON:0002616 ! regional part of brain relationship: BFO:0000050 UBERON:0001894 ! part of diencephalon property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/8/8c/HypothalamicNuclei.PNG" xsd:anyURI property_value: RO:0002175 NCBITaxon:7742 property_value: skos:prefLabel "preoptic area" xsd:string [Term] id: UBERON:0001930 name: paraventricular nucleus of hypothalamus def: "Nucleus in the anterior part of the hypothalamus. (MSH) * one of the magnocellular hypothalamic nuclei, an elongated plate of large, deeply staining cells located close to the third ventricle in the anterior hypothalamic area; major source of oxytocin and to a lesser extent, of antidiuretic hormone, neurohormones, which are carried to the neurohypophysis along the paraventriculohypophysial tract. (CSP)." [BIRNLEX:1407] subset: efo_slim subset: pheno_slim subset: uberon_slim synonym: "filiform nucleus" EXACT [] synonym: "nuclei paraventriculares" RELATED OMO:0003011 [NeuroNames:387] synonym: "nuclei paraventricularis hypothalami" RELATED OMO:0003011 [Wikipedia:Paraventricular_nucleus_of_hypothalamus] synonym: "nucleus filiformis" RELATED OMO:0003011 [NeuroNames:387] synonym: "nucleus hypothalami filiformis" RELATED OMO:0003011 [NeuroNames:387] synonym: "nucleus hypothalami paraventricularis" RELATED OMO:0003011 [NeuroNames:387] synonym: "nucleus paraventricularis hypothalami" RELATED [BTO:0002476] synonym: "Pa" BROAD OMO:0003000 [BIRNLEX:1407, NIFSTD:NeuroNames_abbrevSource] synonym: "paraventricular hypothalamic nucleus" EXACT [] synonym: "paraventricular nucleus" EXACT [] synonym: "paraventricular nucleus hypothalamus (Malone)" RELATED [NeuroNames:387] synonym: "paraventricular nucleus of the hypothalamus" RELATED [NeuroNames:387] synonym: "parvocellular hypothalamic nucleus" RELATED [BAMS:PVH] synonym: "subcommissural nucleus (Ziehen)" RELATED [NeuroNames:387] xref: BAMS:Pa xref: BAMS:PAH xref: BAMS:PVH xref: BIRNLEX:1407 xref: BM:Die-Hy-PAH xref: BTO:0002476 xref: DHBA:10476 xref: EFO:0002469 xref: EMAPA:35665 xref: EV:0100229 xref: FMA:62320 xref: GAID:643 xref: HBA:12905 xref: MA:0000848 xref: MBA:38 xref: MESH:D010286 xref: neuronames:387 {source="BIRNLEX:1407"} xref: SCTID:369131006 xref: UMLS:C0030532 {source="BIRNLEX:1407"} xref: Wikipedia:Paraventricular_nucleus_of_hypothalamus is_a: UBERON:0006568 ! hypothalamic nucleus relationship: BFO:0000050 UBERON:0002271 ! part of periventricular zone of hypothalamus relationship: RO:0002433 UBERON:0001898 ! contributes to morphology of hypothalamus property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/e/ef/PVNss.jpg" xsd:anyURI property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/en/thumb/e/ef/PVNss.jpg/200px-PVNss.jpg" xsd:anyURI property_value: skos:prefLabel "paraventricular nucleus of hypothalamus" xsd:string [Term] id: UBERON:0001932 name: arcuate nucleus of hypothalamus def: "The arcuate nucleus (or infundibular nucleus) is an aggregation of neurons in the mediobasal hypothalamus, adjacent to the third ventricle and the median eminence. The arcuate nucleus includes several important populations of neurons, including: Neuroendocrine neurons, Centrally-projecting neurons and Others. [WP,unvetted]." [Wikipedia:Arcuate_nucleus] subset: uberon_slim synonym: "ArcH" BROAD OMO:0003000 [BIRNLEX:1638, NIFSTD:NeuroNames_abbrevSource] synonym: "arcuate hypothalamic nucleus" EXACT [] synonym: "arcuate nucleus" EXACT [] synonym: "arcuate nucleus of the hypothalamus" RELATED [NeuroNames:395] synonym: "arcuate nucleus-2" EXACT [] synonym: "arcuate periventricular nucleus" EXACT [] synonym: "infundibular hypothalamic nucleus" EXACT [] synonym: "infundibular nucleus" EXACT [] synonym: "infundibular periventricular nucleus" EXACT [] synonym: "nucleus arcuatus" EXACT OMO:0003011 [FMA:62329, FMA:TA] synonym: "nucleus arcuatus (hypothalamus)" RELATED OMO:0003011 [NeuroNames:395] synonym: "nucleus arcuatus hypothalami" RELATED OMO:0003011 [Wikipedia:Arcuate_nucleus] synonym: "nucleus infundibularis" RELATED [BTO:0002473] synonym: "nucleus infundibularis hypothalami" RELATED OMO:0003011 [NeuroNames:395] synonym: "nucleus semilunaris" RELATED [BTO:0002473] xref: BAMS:Arc xref: BAMS:ArcH xref: BAMS:ARH xref: BIRNLEX:1638 xref: BM:HAr xref: BTO:0002473 xref: BTO:0005534 xref: DHBA:10492 xref: EMAPA:35142 xref: EV:0100230 xref: FMA:62329 xref: GAID:647 xref: HBA:12913 xref: MA:0000847 xref: MBA:223 xref: MESH:D001111 xref: NCIT:C52711 xref: neuronames:395 {source="BIRNLEX:1638"} xref: UMLS:C0003741 {source="BIRNLEX:1638", source="ncithesaurus:Arcuate_Nucleus"} xref: Wikipedia:Arcuate_nucleus is_a: UBERON:0006568 ! hypothalamic nucleus relationship: BFO:0000050 UBERON:0002271 ! part of periventricular zone of hypothalamus relationship: BFO:0000050 UBERON:0002555 {source="NIFSTD"} ! part of intermediate hypothalamic region property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/8/8c/HypothalamicNuclei.PNG" xsd:anyURI property_value: skos:prefLabel "arcuate nucleus of hypothalamus" xsd:string [Term] id: UBERON:0001943 name: midbrain tegmentum def: "Ventral part of the midbrain, separated from the hindbrain by the isthmus[ISBN:0471888893]. Subdivision of the midbrain lying anterior to the tectum and posterior to the substantia nigra and cerebral peduncle[FMA] The part of the midbrain extending from the substantia nigra to the cerebral aqueduct in a horizontal section of the midbrain. It forms the floor of the midbrain that surrounds the cerebral aqueduct[WP]." [FMA:FMA, ISBN:0471888893, Wikipedia:Midbrain_tegmentum] comment: 'tegmentum' is used generically for the ventral part of the brainstem (ISBN:0471888893). We use the label 'midbrain tegmentum' to denote the midbrain structure. In NIFSTD tegmentum is a composite structure and there is a separate class for midbrain tegmentum and pontine tegmentum subset: efo_slim subset: human_reference_atlas subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "mesencephalic tegmentum" RELATED [VHOG:0001367] synonym: "MTg" BROAD OMO:0003000 [BIRNLEX:1200, NIFSTD:NeuroNames_abbrevSource] synonym: "tegmentum" BROAD [ISBN:0471888893] synonym: "tegmentum mesencephali" EXACT OMO:0003011 [Wikipedia:Midbrain_tegmentum] synonym: "tegmentum mesencephalicum" RELATED OMO:0003011 [NeuroNames:491] synonym: "tegmentum of midbrain" EXACT [] xref: BAMS:MTg xref: BIRNLEX:1200 xref: BTO:0003388 xref: DHBA:12195 xref: EFO:0000921 xref: EHDAA2:0004475 xref: EMAPA:18215 xref: FMA:62393 xref: HBA:9002 xref: MA:0000212 xref: MAT:0000452 xref: MESH:D013681 {sssom:mapping_justification="https://w3id.org/semapv/vocab/LexicalMatching"} xref: neuronames:491 {source="BIRNLEX:1200"} xref: SCTID:362392007 xref: TAO:0000160 xref: UMLS:C0039441 {source="BIRNLEX:1200"} xref: VHOG:0001367 xref: Wikipedia:Midbrain_tegmentum xref: XAO:0004271 xref: ZFA:0000160 is_a: UBERON:0002616 ! regional part of brain relationship: BFO:0000050 UBERON:0001891 ! part of midbrain relationship: BFO:0000050 UBERON:0002298 ! part of brainstem relationship: RO:0002202 UBERON:0010285 {source="ZFA"} ! develops from midbrain basal plate property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/b/b6/Gray712.png" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "midbrain tegmentum" xsd:string [Term] id: UBERON:0001944 name: pretectal region def: "Nuclear complex between dorsal thalamus and optic tectum whose nuclei receive afferents primarily from the retina and the optic tectum and are involved in modulating motor behavior in response to visual input." [https://github.com/obophenotype/uberon/issues/361, ISBN:0471888893] subset: human_reference_atlas subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "area praetectalis" RELATED OMO:0003011 [NeuroNames:467] synonym: "area pretectalis" EXACT OMO:0003011 [FMA:62402, FMA:TA] synonym: "nuclei pretectales" EXACT OMO:0003011 [FMA:62402, FMA:TA] synonym: "nucleus praetectalis" RELATED OMO:0003011 [NeuroNames:467] synonym: "praetectum" RELATED OMO:0003011 [NeuroNames:467] synonym: "pretectal area" EXACT [] synonym: "pretectal nuclei" EXACT [] synonym: "pretectum" EXACT [] synonym: "regio pretectalis" RELATED OMO:0003011 [NeuroNames:467] xref: BAMS:PRT xref: BAMS:PTc xref: BAMS:PTec xref: BIRNLEX:703 xref: BM:MB-Tec-PT xref: DHBA:12181 xref: DMBA:16510 xref: EMAPA:32778 xref: FMA:62402 xref: HBA:9079 xref: MA:0001062 xref: MBA:1100 xref: neuronames:467 {source="BIRNLEX:703"} xref: NLX:59721 xref: SCTID:416333003 xref: TAO:0000418 xref: UMLS:C0175354 {source="BIRNLEX:703"} xref: Wikipedia:Pretectal_area xref: Wikipedia:Pretectum xref: XAO:0004303 xref: ZFA:0000418 is_a: UBERON:0003528 ! brain gray matter is_a: UBERON:0007245 {source="cjm"} ! nuclear complex of neuraxis relationship: RO:0002131 UBERON:0001891 ! overlaps midbrain relationship: RO:0002131 UBERON:0001894 ! overlaps diencephalon relationship: RO:0002220 UBERON:0004703 {source="ISBN:0471888893"} ! adjacent to dorsal thalamus property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "pretectal region" xsd:string property_value: terms:contributor https://orcid.org/0000-0002-6601-2165 [Term] id: UBERON:0001948 name: regional part of spinal cord def: "A multi-tissue structure that is part of a spinal cord." [OBOL:automatic] subset: non_informative synonym: "spinal cord part" RELATED [] xref: BIRNLEX:1496 xref: NCIT:C33969 xref: SCTID:244437008 xref: UMLS:C1268166 {source="ncithesaurus:Spinal_Cord_Part"} is_a: UBERON:0000073 ! regional part of nervous system intersection_of: UBERON:0000481 ! multi-tissue structure intersection_of: BFO:0000050 UBERON:0002240 ! part of spinal cord relationship: BFO:0000050 UBERON:0002240 ! part of spinal cord property_value: skos:prefLabel "regional part of spinal cord" xsd:string [Term] id: UBERON:0001949 name: gingival epithelium def: "A stratified squamous epithelium consisting of a basal layer; it is keratinized or parakeratinized[BTO]." [BTO:0004998] subset: human_reference_atlas synonym: "epithelial tissue of gingiva" EXACT [OBOL:automatic] synonym: "epithelium of gingiva" EXACT [] synonym: "gingiva epithelial tissue" EXACT [OBOL:automatic] synonym: "gingiva epithelium" EXACT [OBOL:automatic] xref: BTO:0004998 xref: FMA:62423 xref: MA:0001576 xref: NCIT:C49239 xref: UMLS:C1179154 {source="ncithesaurus:Gingival_Epithelium"} is_a: UBERON:0002424 ! oral epithelium is_a: UBERON:0006915 ! stratified squamous epithelium is_a: UBERON:0035037 ! jaw epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: BFO:0000050 UBERON:0001828 ! part of gingiva relationship: BFO:0000050 UBERON:0001828 ! part of gingiva property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001950 name: neocortex def: "An area of cerebral cortex defined on the basis of cytoarchitecture that have six layers. Starting from the cortical surface the layers are: molecular layer (I), external granular layer (II), external pyramidal layer (III), internal granular layer (IV), internal pyramidal layer (V), and multiform layer (VI). Neocortex is most prominent in the frontal lobe, the parietal lobe, the temporal lobe and the occipital lobe, less so in the cingulate gyrus, the parahippocampal gyrus and the insula. It is composed of two subdivisions: true isocortex and proisocortex (Carpenter-83)(NN)." [BIRNLEX:2547, OldNeuroNames:754] subset: pheno_slim subset: uberon_slim synonym: "cerebral neocortex" EXACT [] synonym: "homogenetic cortex" EXACT DEPRECATED [ISBN:0471888893] synonym: "homotypical cortex" EXACT [BIRNLEX:2547] synonym: "iso-cortex" RELATED [BAMS:iso-cortex] synonym: "isocortex" NARROW [BRAINSPAN:BRAINSPAN] synonym: "isocortex (sensu lato)" EXACT [FMA:62429] synonym: "neocortex (isocortex)" EXACT [DHBA:10160] synonym: "neopallial cortex" EXACT [] synonym: "neopallium" EXACT [] synonym: "nonolfactory cortex" RELATED [BTO:0000920] synonym: "nucleus hypoglossalis" RELATED OMO:0003011 [NeuroNames:757] xref: BAMS:ISO xref: BAMS:Iso-cortex xref: BAMS:NCX xref: BIRNLEX:2547 xref: BTO:0000920 xref: DHBA:10160 xref: EHDAA2:0004662 xref: EMAPA:32842 xref: EMAPA:35589 xref: FMA:62429 xref: GAID:677 xref: MA:0002754 xref: MBA:315 xref: MESH:D019579 xref: neuronames:757 {source="BIRNLEX:2547"} xref: PBA:294021746 xref: UMLS:C0175173 {source="BIRNLEX:2547"} xref: Wikipedia:Neocortex is_a: UBERON:0002616 ! regional part of brain relationship: BFO:0000050 UBERON:0000956 ! part of cerebral cortex relationship: RO:0002433 UBERON:0000956 ! contributes to morphology of cerebral cortex property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/7/77/Neocortex.jpg" xsd:anyURI property_value: skos:prefLabel "neocortex" xsd:string [Term] id: UBERON:0001951 name: epithelium of nasopharynx def: "An epithelium that is part of a nasopharynx [Automatically generated definition]." [OBOL:automatic] synonym: "epithelial tissue of nasal part of pharynx" EXACT [OBOL:automatic] synonym: "epithelial tissue of nasopharynx" EXACT [OBOL:automatic] synonym: "epithelial tissue of rhinopharynx" EXACT [OBOL:automatic] synonym: "epithelium of nasal part of pharynx" EXACT [OBOL:automatic] synonym: "epithelium of rhinopharynx" EXACT [OBOL:automatic] synonym: "nasal part of pharynx epithelial tissue" EXACT [OBOL:automatic] synonym: "nasal part of pharynx epithelium" EXACT [OBOL:automatic] synonym: "nasopharyngeal epithelium" RELATED [BTO:0004480] synonym: "nasopharynx epithelial tissue" EXACT [OBOL:automatic] synonym: "nasopharynx epithelium" EXACT [] synonym: "rhinopharynx epithelial tissue" EXACT [OBOL:automatic] synonym: "rhinopharynx epithelium" EXACT [OBOL:automatic] xref: BTO:0004480 xref: CALOHA:TS-0662 xref: EHDAA2:0001241 xref: EHDAA:7090 xref: EMAPA:17672 xref: FMA:62452 xref: MA:0001865 xref: NCIT:C49263 xref: UMLS:C1179157 {source="ncithesaurus:Nasopharynx_Epithelium"} xref: VHOG:0001038 is_a: UBERON:0003351 ! pharyngeal epithelium is_a: UBERON:0004814 ! upper respiratory tract epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: BFO:0000050 UBERON:0001728 ! part of nasopharynx relationship: BFO:0000050 UBERON:0001728 ! part of nasopharynx relationship: BFO:0000050 UBERON:0003929 {source="EHDAA2"} ! part of digestive tract epithelium [Term] id: UBERON:0001954 name: Ammon's horn def: "A part of the brain consisting of a three layered cortex located in the forebrain bordering the medial surface of the lateral ventricle. The term hippocampus is often used synonymously with hippocampal formation which consists of the hippocampus proper or Cornu Ammonis, the dentate gyrus and the subiculum." [BIRNLEX:721] subset: efo_slim subset: pheno_slim subset: uberon_slim synonym: "ammon gyrus" EXACT [GO:0021541] synonym: "ammon horn" EXACT [BIRNLEX:721] synonym: "Ammon horn fields" RELATED [BAMS:CA] synonym: "Ammon's horn" EXACT [GO:0021541] synonym: "Ammons horn" RELATED [BTO:0003705] synonym: "cornu ammonis" RELATED [GO:0021541] synonym: "hippocampus" RELATED [MA:0000191] synonym: "hippocampus major" EXACT [] synonym: "hippocampus proper" EXACT [BIRNLEX:721] synonym: "hippocampus proprius" EXACT OMO:0003011 [FMA:62493, FMA:TA] xref: BAMS:CA xref: BIRNLEX:721 xref: BM:Tel-CAM xref: BTO:0003705 xref: CALOHA:TS-0460 xref: DHBA:10296 xref: DMBA:16124 xref: EFO:0000530 xref: EHDAA2:0004443 xref: EMAPA:32845 xref: EV:0100180 xref: FMA:62493 xref: GAID:623 xref: http://scalablebrainatlas.incf.org/services/thumbnail.php?template=ABA07&size=L&dim=2d3d&format=png®ion=CA xref: MA:0000191 xref: MAT:0000114 xref: MBA:375 xref: MESH:D006624 xref: MIAA:0000114 xref: NCIT:C12444 xref: NCIT:C32374 xref: neuronames:3157 xref: PBA:128012244 xref: SCTID:361561007 xref: UMLS:C0019564 {source="BIRNLEX:721", source="ncithesaurus:Hippocampus"} xref: VHOG:0001177 xref: Wikipedia:Hippocampus is_a: UBERON:0002616 ! regional part of brain relationship: BFO:0000050 UBERON:0000349 {source="FMA"} ! part of limbic system relationship: BFO:0000050 UBERON:0002421 {source="ABA"} ! part of hippocampal formation relationship: BFO:0000050 UBERON:0002600 {source="FMA"} ! part of limbic lobe relationship: RO:0002216 GO:0007613 {source="Wikipedia"} ! capable of part of memory property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/2/2e/Gray739-emphasizing-hippocampus.png" xsd:anyURI property_value: skos:prefLabel "Ammon's horn" xsd:string [Term] id: UBERON:0001955 name: epithelium of respiratory bronchiole def: "An epithelium that is part of a respiratory bronchiole [Automatically generated definition]." [OBOL:automatic] subset: human_reference_atlas synonym: "bronchiolus respiratorius epithelial tissue" EXACT [OBOL:automatic] synonym: "bronchiolus respiratorius epithelium" EXACT [OBOL:automatic] synonym: "epithelial tissue of bronchiolus respiratorius" EXACT [OBOL:automatic] synonym: "epithelial tissue of respiratory bronchiole" EXACT [OBOL:automatic] synonym: "epithelium of bronchiolus respiratorius" EXACT [OBOL:automatic] synonym: "respiratory bronchiole epithelial tissue" EXACT [OBOL:automatic] synonym: "respiratory bronchiole epithelium" EXACT [] xref: EMAPA:35730 xref: FMA:62498 xref: MA:0001773 xref: NCIT:C48943 xref: UMLS:C1179179 {source="ncithesaurus:Respiratory_Bronchiole_Epithelium"} is_a: UBERON:0002051 ! epithelium of bronchiole intersection_of: UBERON:0000483 ! epithelium intersection_of: BFO:0000050 UBERON:0002188 ! part of respiratory bronchiole relationship: BFO:0000050 UBERON:0002188 ! part of respiratory bronchiole property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001956 name: cartilage of bronchus def: "The hyaline cartilaginous structures that support the bronchi, present as irregular rings in the larger bronchi (and not as regular as in the trachea), and as small plates and islands in the smaller bronchi; as the branching continues through the bronchial tree, the amount of hyaline cartilage in the walls decreases until it is absent in the smallest bronchioles[MP]." [MP:0010988] subset: human_reference_atlas subset: pheno_slim synonym: "bronchi cartilage" EXACT [OBOL:automatic] synonym: "bronchial cartilage" EXACT [] synonym: "bronchial cartilage ring" EXACT [MP:0010988] synonym: "bronchial trunk cartilage" EXACT [OBOL:automatic] synonym: "bronchus cartilage" EXACT [] synonym: "cartilage of bronchi" EXACT [OBOL:automatic] synonym: "cartilage of bronchial trunk" EXACT [OBOL:automatic] synonym: "cartilagines bronchiales" EXACT OMO:0003004 [] xref: EMAPA:35192 xref: FMA:62649 xref: MA:0001835 xref: NCIT:C49209 xref: SCTID:278980009 xref: UMLS:C0225604 {source="ncithesaurus:Bronchus_Cartilage"} is_a: UBERON:0003603 ! lower respiratory tract cartilage intersection_of: UBERON:0007844 ! cartilage element intersection_of: BFO:0000050 UBERON:0002185 ! part of bronchus relationship: BFO:0000050 UBERON:0002185 ! part of bronchus relationship: BFO:0000051 CL:0019002 ! has part tracheobronchial chondrocyte relationship: RO:0002433 UBERON:0002185 ! contributes to morphology of bronchus relationship: RO:0002473 UBERON:0001994 {source="MP"} ! composed primarily of hyaline cartilage tissue property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "cartilage of bronchus" xsd:string property_value: terms:contributor https://orcid.org/0000-0001-6677-8489 [Term] id: UBERON:0001957 name: submucosa of bronchus def: "A submucosa that is part of a bronchus [Automatically generated definition]." [OBOL:automatic] synonym: "bronchi submucosa" EXACT [OBOL:automatic] synonym: "bronchial submucosa" EXACT [] synonym: "bronchial trunk submucosa" EXACT [OBOL:automatic] synonym: "bronchus submucosa" EXACT [] synonym: "submucosa of bronchi" EXACT [OBOL:automatic] synonym: "submucosa of bronchial trunk" EXACT [OBOL:automatic] synonym: "submucous layer of bronchi" RELATED [BTO:0002108] synonym: "tela submucosa bronchi" EXACT OMO:0003011 [FMA:62653, FMA:TA] xref: BTO:0002108 xref: EMAPA:37449 {source="MA:th"} xref: FMA:62653 xref: MA:0001837 xref: NCIT:C49214 xref: SCTID:85546005 xref: UMLS:C0225601 {source="ncithesaurus:Bronchus_Submucosa"} is_a: UBERON:0004777 ! respiratory system submucosa intersection_of: UBERON:0000009 ! submucosa intersection_of: BFO:0000050 UBERON:0002185 ! part of bronchus relationship: BFO:0000050 UBERON:0002185 ! part of bronchus property_value: skos:prefLabel "submucosa of bronchus" xsd:string [Term] id: UBERON:0001958 name: terminal bronchiole epithelium def: "An epithelium that lines a terminal bronchiole." [http://orcid.org/0000-0002-6601-2165] subset: human_reference_atlas synonym: "bronchiolus terminalis epithelial tissue" EXACT [OBOL:automatic] synonym: "bronchiolus terminalis epithelium" EXACT [OBOL:automatic] synonym: "epithelial tissue of bronchiolus terminalis" EXACT [OBOL:automatic] synonym: "epithelial tissue of terminal bronchiole" EXACT [OBOL:automatic] synonym: "epithelium of bronchiolus terminalis" EXACT [OBOL:automatic] synonym: "epithelium of terminal bronchiole" EXACT [FMA:62794] synonym: "terminal bronchiole epithelial tissue" EXACT [OBOL:automatic] synonym: "terminal bronchiole epithelium" EXACT [] xref: EMAPA:36283 xref: FMA:62794 xref: MA:0001774 xref: NCIT:C33755 xref: UMLS:C1179400 {source="ncithesaurus:Terminal_Bronchiole_Epithelium"} is_a: UBERON:0002051 ! epithelium of bronchiole intersection_of: UBERON:0000483 ! epithelium intersection_of: BFO:0000050 UBERON:0002187 ! part of terminal bronchiole relationship: BFO:0000050 UBERON:0002187 ! part of terminal bronchiole property_value: RO:0002175 NCBITaxon:9606 property_value: terms:contributor https://orcid.org/0000-0001-6677-8489 [Term] id: UBERON:0001959 name: white pulp of spleen def: "The parenchymatous tissue of the spleen that surrounds splenic blood vessels, consists of compact masses of lymphatic cells and is where foreign material removed from the blood is used to initiate an immune reaction that results in the production of antibodies." [MGI:csmith, MP:0002357] subset: human_reference_atlas subset: pheno_slim subset: uberon_slim synonym: "noduli lymphoidei splenici" RELATED OMO:0003011 [Wikipedia:White_pulp] synonym: "pulpa alba" EXACT OMO:0003011 [FMA:62805, FMA:TA] synonym: "spleen white pulp" EXACT [] synonym: "splenic white pulp" EXACT [] synonym: "white pulp" EXACT [] xref: CALOHA:TS-1264 xref: EMAPA:35809 xref: FMA:62805 xref: MA:0000762 xref: NCIT:C12993 xref: UMLS:C0229686 {source="ncithesaurus:Splenic_White_Pulp"} xref: Wikipedia:White_pulp is_a: BFO:0000002 is_a: UBERON:1000023 ! spleen pulp relationship: RO:0002433 UBERON:0002106 ! contributes to morphology of spleen relationship: RO:0002473 CL:0000542 ! composed primarily of lymphocyte property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/1/15/Gray1191.png" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001960 name: periarterial lymphatic sheath def: "The area of the spleen in which T cells surround the central arteriole." [MP:0002358] subset: human_reference_atlas subset: pheno_slim synonym: "PALS" EXACT OMO:0003000 [MP:0002358] synonym: "periarterial lymphoid sheath" EXACT [] synonym: "periarteriolar sheath" EXACT [MP:0002358] synonym: "spleen periarteriolar lymphatic sheath" EXACT [] synonym: "splenic periarteriolar lymphoid sheath" RELATED [MP:0002358] synonym: "T cell domain of the splenic white pulp" EXACT [MP:0002358] xref: EMAPA:37750 {source="MA:th"} xref: FMA:62810 xref: MA:0000765 is_a: UBERON:0004177 ! hemopoietic organ is_a: UBERON:0005172 ! abdomen element is_a: UBERON:0010393 ! T cell domain intersection_of: UBERON:0010393 ! T cell domain intersection_of: BFO:0000050 UBERON:0001959 ! part of white pulp of spleen relationship: BFO:0000050 UBERON:0001959 ! part of white pulp of spleen relationship: RO:0002433 UBERON:0001959 ! contributes to morphology of white pulp of spleen property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001961 name: mucosa-associated lymphoid tissue def: "Diffuse system of small concentrations of lymphoid tissue found in various sites of the body such as the gastrointestinal tract, thyroid, breast, lung, salivary glands, eye, and skin[WP]. Mucosal-associated lymphoid tissue is typically found as nodules associated with mucosal epithelia with distinct internal structures including B- and T-zones for the activation of lymphocytes[GO]." [Wikipedia:Mucosa-associated_lymphoid_tissue] subset: human_reference_atlas subset: pheno_slim subset: uberon_slim synonym: "epithelio-lymphoid tissue" EXACT [FMA:62819] synonym: "MALT" EXACT [] synonym: "mucosa associated lymphatic tissue" EXACT [] synonym: "mucosa associated lymphoid tissue" EXACT [] synonym: "mucosa-associated lymphoid tissue" EXACT [GO:0048537] synonym: "mucosal-associated lymphatic tissue" EXACT [GO:0048537] synonym: "mucosal-associated lymphoid tissue" EXACT [GO:0048537] xref: FMA:62819 xref: MA:0000140 xref: NCIT:C12910 xref: UMLS:C0599921 {source="ncithesaurus:Mucosa-Associated_Lymphoid_Tissue"} xref: Wikipedia:Mucosa-associated_lymphoid_tissue is_a: UBERON:0012069 {source="FMA"} ! epithelium-associated lymphoid tissue relationship: BFO:0000067 GO:0046649 ! contains process lymphocyte activation relationship: RO:0002131 UBERON:0000344 ! overlaps mucosa property_value: IAO:0000116 "todo - add part relationships to specific layers" xsd:string property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001962 name: gut-associated lymphoid tissue def: "Mucosa-associated lymphoid tissue in digestive tract. includes Peyer's patches, appendix, and solitary lymph nodules[GO]." [Wikipedia:Gut-associated_lymphoid_tissue] subset: human_reference_atlas subset: pheno_slim subset: uberon_slim synonym: "GALT" RELATED [] synonym: "gut associated lymphoid tissue" EXACT [] xref: FMA:62820 xref: MA:0000136 xref: NCIT:C12936 xref: UMLS:C0596638 {source="ncithesaurus:Gut_Associated_Lymphoid_Tissue"} xref: Wikipedia:Gut-associated_lymphoid_tissue is_a: UBERON:0001961 ! mucosa-associated lymphoid tissue intersection_of: UBERON:0001961 ! mucosa-associated lymphoid tissue intersection_of: BFO:0000050 UBERON:0001555 ! part of digestive tract relationship: BFO:0000050 UBERON:0001555 ! part of digestive tract property_value: IAO:0000116 "phylogenetic relationships to be added" xsd:string property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001963 name: bronchial-associated lymphoid tissue def: "A diffuse collection of lymphpoid cells that participate in airway immune responses." [ISBN:0123813611] comment: Lymphoid tissue associated with airways in mice has functional similarities to human BALT[ISBN:0123813611] Notes: FMA classifies this as organized, not diffuse subset: pheno_slim synonym: "BALT" RELATED [] synonym: "bronchus associated lymphoid tissue" EXACT [] xref: FMA:62821 xref: MA:0000135 xref: NCIT:C32234 xref: UMLS:C1179418 {source="ncithesaurus:Bronchus-Associated_Lymphoid_Tissue"} is_a: UBERON:0001961 ! mucosa-associated lymphoid tissue intersection_of: UBERON:0001961 ! mucosa-associated lymphoid tissue intersection_of: BFO:0000050 UBERON:0002185 ! part of bronchus relationship: BFO:0000050 UBERON:0002185 ! part of bronchus relationship: RO:0002131 UBERON:0001957 {source="ISBN:0123813611"} ! overlaps submucosa of bronchus [Term] id: UBERON:0001968 name: semen def: "Organism substance that is composed of sperm cells suspended in seminal fluid." [http://orcid.org/0000-0002-6601-2165] subset: pheno_slim subset: uberon_slim synonym: "ejaculate" RELATED [] synonym: "sperm" RELATED [BTO:0001230] xref: BTO:0001230 xref: CALOHA:TS-0917 xref: EMAPA:31488 xref: FMA:62966 xref: GAID:1169 xref: MA:0002522 xref: MESH:D012661 xref: NCIT:C13277 xref: NCIT:C13713 xref: UMLS:C1518159 {source="ncithesaurus:Male_Genital_System_Fluid_or_Secretion"} xref: UMLS:C2756969 {source="ncithesaurus:Semen"} xref: Wikipedia:Semen is_a: BFO:0000002 is_a: UBERON:0000463 ! organism substance relationship: BFO:0000051 CL:0000019 ! has part sperm relationship: BFO:0000051 UBERON:0006530 ! has part seminal fluid relationship: RO:0002353 GO:0042713 ! output of sperm ejaculation property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/4/40/Human_semen_in_petri_dish2.jpg" xsd:anyURI [Term] id: UBERON:0001969 name: blood plasma def: "The liquid component of blood, in which erythrocytes are suspended." [http://orcid.org/0000-0002-6601-2165] subset: efo_slim subset: pheno_slim subset: uberon_slim synonym: "blood plasm" EXACT [] synonym: "plasma" BROAD [MA:0002501] synonym: "portion of blood plasma" EXACT [] synonym: "portion of plasma" BROAD [FMA:62970] xref: BTO:0000131 xref: CALOHA:TS-0800 xref: EFO:0001905 xref: EMAPA:35690 xref: FMA:62970 xref: GAID:1178 xref: MA:0002501 xref: MAT:0000052 xref: MESH:D010949 xref: MIAA:0000052 xref: NCIT:C13356 xref: UMLS:C0032105 {source="ncithesaurus:Plasma"} xref: Wikipedia:Blood_plasma is_a: UBERON:0000179 ! haemolymphatic fluid intersection_of: UBERON:0000463 ! organism substance intersection_of: BFO:0000050 UBERON:0000178 ! part of blood intersection_of: BFO:0000051 GO:0005577 ! has part fibrinogen complex intersection_of: RO:0000086 PATO:0001548 ! has quality quality of a liquid intersection_of: RO:0002221 CL:0000232 ! surrounds erythrocyte relationship: BFO:0000050 UBERON:0000178 ! part of blood relationship: BFO:0000051 GO:0005577 ! has part fibrinogen complex relationship: RO:0002221 CL:0000232 ! surrounds erythrocyte property_value: skos:prefLabel "blood plasma" xsd:string [Term] id: UBERON:0001970 name: bile def: "Vital aqueous secretion of the liver that is formed by hepatocytes and modified down stream by absorptive and secretory properties of the bile duct epithelium." [DOI:10.1002/cphy.c120027, Wikipedia:Bile] subset: pheno_slim subset: uberon_slim synonym: "fel" RELATED [BTO:0000121] synonym: "gall" RELATED [BTO:0000121] xref: BTO:0000121 xref: CALOHA:TS-1172 xref: ENVO:02000023 xref: FMA:62971 xref: GAID:1157 xref: galen:Bile xref: MA:0002513 xref: MESH:D001646 xref: NCIT:C13192 xref: UMLS:C0005388 {source="ncithesaurus:Bile"} xref: Wikipedia:Bile xref: ZFA:0005857 is_a: UBERON:0000456 ! secretion of exocrine gland is_a: UBERON:0006314 ! bodily fluid intersection_of: UBERON:0000456 ! secretion of exocrine gland intersection_of: RO:0003001 UBERON:0002107 ! produced by liver relationship: BFO:0000051 CHEBI:16990 ! has part relationship: BFO:0000051 CHEBI:22868 ! has part relationship: BFO:0000051 CHEBI:36277 ! has part relationship: RO:0000086 PATO:0001735 ! has quality liquid configuration relationship: RO:0002216 GO:0007586 ! capable of part of digestion relationship: RO:0003001 UBERON:0002107 ! produced by liver property_value: skos:prefLabel "bile" xsd:string [Term] id: UBERON:0001971 name: gastric juice subset: pheno_slim subset: uberon_slim synonym: "stomach secretion" EXACT [] synonym: "succus gastricus" RELATED [BTO:0000501] xref: BTO:0000501 xref: FMA:62972 xref: GAID:1160 xref: galen:GastricJuice xref: MA:0002519 xref: MESH:D005750 xref: NCIT:C32661 xref: UMLS:C0017133 {source="ncithesaurus:Gastric_Secretion"} xref: Wikipedia:Gastric_juice is_a: UBERON:0000456 ! secretion of exocrine gland intersection_of: UBERON:0000456 ! secretion of exocrine gland intersection_of: RO:0003001 UBERON:0011953 ! produced by stomach glandular region relationship: RO:0003001 UBERON:0011953 ! produced by stomach glandular region property_value: skos:prefLabel "gastric juice" xsd:string [Term] id: UBERON:0001972 name: submucosa of esophagus def: "A submucosa that is part of a esophagus [Automatically generated definition]." [OBOL:automatic] synonym: "esophageal submucosa" EXACT [] synonym: "esophagus submucosa" EXACT [] synonym: "gullet submucosa" EXACT [OBOL:automatic] synonym: "oesophagus submucosa" EXACT [OBOL:automatic] synonym: "submucosa of esophagus" EXACT [] synonym: "submucosa of gullet" EXACT [OBOL:automatic] synonym: "submucosa of oesophagus" EXACT [OBOL:automatic] synonym: "submucous layer of esophagus" RELATED [BTO:0002109] synonym: "tela submucosa (oesophagus)" EXACT OMO:0003011 [FMA:62997, FMA:TA] synonym: "tela submucosa esophagi" EXACT OMO:0003011 [BTO:0002109] synonym: "tela submucosa oesophageae" EXACT OMO:0003011 [FMA:62997, FMA:TA] synonym: "tela submucosa oesophagi" RELATED [BTO:0002109] synonym: "tela submucosa of esophagus" EXACT [] xref: BTO:0002109 xref: EMAPA:35325 xref: FMA:62997 xref: MA:0002724 xref: SCTID:362128009 is_a: UBERON:0018257 ! submucosa of digestive tract intersection_of: UBERON:0000009 ! submucosa intersection_of: BFO:0000050 UBERON:0001043 ! part of esophagus relationship: BFO:0000050 UBERON:0001096 ! part of wall of esophagus property_value: skos:prefLabel "submucosa of esophagus" xsd:string [Term] id: UBERON:0001974 name: lamina propria of esophagus def: "A lamina propria that is part of a esophagus [Automatically generated definition]." [OBOL:automatic] synonym: "esophageal lamina propria" RELATED [EMAPA:26987] synonym: "esophagus lamina propria" EXACT [] synonym: "esophagus lamina propria mucosa" EXACT [OBOL:automatic] synonym: "esophagus lamina propria mucosae" EXACT [OBOL:automatic] synonym: "gullet lamina propria" EXACT [OBOL:automatic] synonym: "gullet lamina propria mucosa" EXACT [OBOL:automatic] synonym: "gullet lamina propria mucosae" EXACT [OBOL:automatic] synonym: "lamina propria mucosa of esophagus" EXACT [OBOL:automatic] synonym: "lamina propria mucosa of gullet" EXACT [OBOL:automatic] synonym: "lamina propria mucosa of oesophagus" EXACT [OBOL:automatic] synonym: "lamina propria mucosae of esophagus" EXACT [] synonym: "lamina propria mucosae of gullet" EXACT [OBOL:automatic] synonym: "lamina propria mucosae of oesophagus" EXACT [OBOL:automatic] synonym: "lamina propria of gullet" EXACT [OBOL:automatic] synonym: "lamina propria of oesophagus" EXACT [OBOL:automatic] synonym: "oesophagus lamina propria" RELATED [] synonym: "oesophagus lamina propria mucosa" EXACT [OBOL:automatic] synonym: "oesophagus lamina propria mucosae" EXACT [OBOL:automatic] xref: EMAPA:26987 xref: FMA:63050 xref: MA:0001568 xref: NCIT:C49223 xref: UMLS:C1707949 {source="ncithesaurus:Esophageal_Lamina_Propria"} is_a: UBERON:0000030 ! lamina propria intersection_of: UBERON:0000030 ! lamina propria intersection_of: BFO:0000050 UBERON:0001043 ! part of esophagus relationship: BFO:0000050 UBERON:0002469 {source="FMA"} ! part of esophagus mucosa property_value: skos:prefLabel "lamina propria of esophagus" xsd:string [Term] id: UBERON:0001975 name: serosa of esophagus def: "A serous membrane that is part of a esophagus [Automatically generated definition]." [OBOL:automatic] synonym: "esophagus serosa" EXACT [] synonym: "esophagus serous membrane" EXACT [OBOL:automatic] synonym: "gullet serosa" EXACT [OBOL:automatic] synonym: "gullet serous membrane" EXACT [OBOL:automatic] synonym: "oesophagus serosa" RELATED [] synonym: "oesophagus serous membrane" EXACT [OBOL:automatic] synonym: "serosa of abdominal part of esophagus" EXACT [] synonym: "serosa of gullet" EXACT [OBOL:automatic] synonym: "serosa of oesophagus" EXACT [] synonym: "serous coat of oesophagus" EXACT [] synonym: "serous membrane of esophagus" EXACT [OBOL:automatic] synonym: "serous membrane of gullet" EXACT [OBOL:automatic] synonym: "serous membrane of oesophagus" EXACT [OBOL:automatic] synonym: "tunica serosa oesophageae" EXACT OMO:0003011 [FMA:63057, FMA:TA] xref: EMAPA:35322 xref: FMA:63057 xref: MA:0001571 is_a: UBERON:0000042 ! serous membrane intersection_of: UBERON:0000042 ! serous membrane intersection_of: BFO:0000050 UBERON:0001043 ! part of esophagus relationship: BFO:0000050 UBERON:0001096 ! part of wall of esophagus property_value: skos:prefLabel "serosa of esophagus" xsd:string [Term] id: UBERON:0001976 name: epithelium of esophagus def: "The epithelial layer that lines the luminal space of the esophagus." [ISBN:0-683-40008-8, MP:0000468] subset: efo_slim subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "epithelial tissue of esophagus" EXACT [OBOL:automatic] synonym: "epithelial tissue of gullet" EXACT [OBOL:automatic] synonym: "epithelial tissue of oesophagus" EXACT [OBOL:automatic] synonym: "epithelium of gullet" EXACT [OBOL:automatic] synonym: "epithelium of oesophagus" EXACT [OBOL:automatic] synonym: "esophageal epithelium" EXACT [] synonym: "esophagus epithelial tissue" EXACT [OBOL:automatic] synonym: "esophagus epithelium" EXACT [] synonym: "gullet epithelial tissue" EXACT [OBOL:automatic] synonym: "gullet epithelium" EXACT [OBOL:automatic] synonym: "oesophagus epithelial tissue" EXACT [OBOL:automatic] synonym: "oesophagus epithelium" RELATED [] xref: BTO:0001578 xref: CALOHA:TS-0698 xref: EFO:0003041 xref: EHDAA2:0001287 xref: EMAPA:16835 xref: FMA:63063 xref: MA:0001565 xref: NCIT:C49221 xref: TAO:0001499 xref: UMLS:C1179544 {source="ncithesaurus:Esophageal_Epithelium"} xref: ZFA:0001499 is_a: UBERON:0003350 ! epithelium of mucosa is_a: UBERON:0003929 ! digestive tract epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: BFO:0000050 UBERON:0001043 ! part of esophagus relationship: BFO:0000050 UBERON:0002469 {source="FMA"} ! part of esophagus mucosa relationship: RO:0002433 UBERON:0001043 ! contributes to morphology of esophagus property_value: IAO:0000116 "TODO check epithelium types: in FMA: Nonkeratinizing stratified squamous epithelium; mouse has basal and squamous subtypes; in ZFA it is columnar" xsd:string property_value: skos:prefLabel "epithelium of esophagus" xsd:string [Term] id: UBERON:0001978 name: parenchyma of pancreas subset: human_reference_atlas synonym: "pancreas parenchyma" EXACT [] synonym: "pancreatic parenchyma" EXACT [] xref: EMAPA:32925 xref: FMA:63120 xref: MA:0000724 xref: SCTID:371401008 xref: VHOG:0001430 is_a: UBERON:0000353 ! parenchyma intersection_of: UBERON:0000353 ! parenchyma intersection_of: BFO:0000050 UBERON:0001264 ! part of pancreas relationship: BFO:0000050 UBERON:0001264 ! part of pancreas property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "parenchyma of pancreas" xsd:string [Term] id: UBERON:0001979 name: venule def: "One of the minute vessels that collect deoxygenated blood from the capillary plexuses returns it to the veins." [MESH:A07.231.432.952, MP:0004125] subset: human_reference_atlas subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "venula" RELATED OMO:0003011 [Wikipedia:Venule] xref: BTO:0002626 xref: EMAPA:35917 xref: FMA:63130 xref: MA:0000071 xref: MESH:D014699 xref: NCIT:C12818 xref: SCTID:341687009 xref: TAO:0005315 xref: UMLS:C0042520 {source="ncithesaurus:Venule"} xref: VHOG:0001765 xref: Wikipedia:Venule xref: ZFA:0005315 is_a: UBERON:0003920 ! venous blood vessel is_a: UBERON:8410081 ! blood microvessel relationship: RO:0002176 UBERON:0001638 ! connects vein relationship: RO:0002176 UBERON:0001982 ! connects capillary property_value: foaf:depiction "https://upload.wikimedia.org/wikipedia/commons/d/da/Illu_capillary.jpg" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "venule" xsd:string [Term] id: UBERON:0001980 name: arteriole def: "The smallest division of the artery located between the muscular arteries and the capillaries[GO]." [GO:0014830] subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "arteriola" RELATED OMO:0003011 [Wikipedia:Arteriole] xref: AAO:0010253 xref: BTO:0001997 xref: EMAPA:35146 xref: FMA:63182 xref: MA:0000063 xref: MESH:D001160 xref: NCIT:C12672 xref: SCTID:337724002 xref: TAO:0002138 xref: UMLS:C0003847 {source="ncithesaurus:Arteriole"} xref: VHOG:0001763 xref: Wikipedia:Arteriole xref: ZFA:0005255 is_a: UBERON:0003509 {source="MA"} ! arterial blood vessel is_a: UBERON:8410081 ! blood microvessel intersection_of: UBERON:0001981 ! blood vessel intersection_of: RO:0002176 UBERON:0001637 ! connects artery intersection_of: RO:0002176 UBERON:0001982 ! connects capillary relationship: RO:0002176 UBERON:0001637 ! connects artery relationship: RO:0002176 UBERON:0001982 ! connects capillary relationship: RO:0002433 UBERON:0001637 ! contributes to morphology of artery property_value: foaf:depiction "https://upload.wikimedia.org/wikipedia/commons/d/da/Illu_capillary.jpg" xsd:anyURI property_value: skos:prefLabel "arteriole" xsd:string [Term] id: UBERON:0001981 name: blood vessel def: "A vessel through which blood circulates in the body." [BTO:0001102, Wikipedia:Blood_vessel] subset: efo_slim subset: human_reference_atlas subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "region of vascular tree organ" EXACT [FMA:50722] synonym: "vas sanguineum" RELATED OMO:0003011 [Wikipedia:Blood_vessel] synonym: "vascular element" BROAD [EMAPA:35993] synonym: "vascular tree organ region" EXACT [FMA:50722] xref: AAO:0011004 xref: AEO:0000207 xref: BTO:0001102 xref: CALOHA:TS-0080 xref: EFO:0000817 xref: EHDAA2:0003252 xref: EHDAA:240 xref: EMAPA:32743 xref: EMAPA:35993 xref: FMA:50722 xref: FMA:63183 xref: GAID:169 xref: MA:0000060 xref: MAT:0000393 xref: MESH:D001808 xref: NCIT:C12679 xref: NLXANAT:090901 xref: SCTID:361097006 xref: TAO:0002137 xref: UMLS:C0005847 {source="ncithesaurus:Blood_Vessel"} xref: VHOG:0001250 xref: Wikipedia:Blood_vessel xref: XAO:0001011 xref: ZFA:0005314 is_a: BFO:0000002 is_a: UBERON:0000055 ! vessel relationship: BFO:0000050 UBERON:0004537 ! part of blood vasculature relationship: BFO:0000051 CL:0000071 {source="AEO"} ! has part blood vessel endothelial cell relationship: BFO:0000051 UBERON:0007500 {source="EHDAA2"} ! has part epithelial tube open at both ends relationship: channel_for UBERON:0000178 ! blood relationship: RO:0000086 PATO:0002045 ! has quality dendritic relationship: RO:0002202 UBERON:0004872 ! develops from splanchnic layer of lateral plate mesoderm relationship: RO:0002202 UBERON:0006965 {source="GO:0072360"} ! develops from vascular cord relationship: RO:0002216 GO:0008015 ! capable of part of blood circulation property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/2/29/Circulatory_System_en.svg" xsd:anyURI property_value: IAO:0000116 "consider adopting the EMAPA superclass 'vascular element', which includes microvasculature (e.g. capillaries), vascular plexus" xsd:string property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "blood vessel" xsd:string [Term] id: UBERON:0001982 name: capillary def: "Any of the smallest blood vessels connecting arterioles with venules." [https://github.com/obophenotype/uberon/issues/137, ISBN:0073040584, Wikipedia:Capillary] subset: efo_slim subset: human_reference_atlas subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "blood capillary" EXACT [] synonym: "capillary vessel" EXACT [] xref: AAO:0010252 xref: BTO:0002045 xref: CALOHA:TS-2006 xref: EFO:0001906 xref: EMAPA:35198 xref: EV:0100035 xref: FMA:63194 xref: MA:0000065 xref: MESH:D002196 xref: NCIT:C12685 xref: NLXANAT:090902 xref: TAO:0005250 xref: UMLS:C0935624 {source="ncithesaurus:Capillary"} xref: VHOG:0001253 xref: Wikipedia:Capillary xref: XAO:0000116 xref: ZFA:0005250 is_a: UBERON:8410081 ! blood microvessel intersection_of: UBERON:8410081 ! blood microvessel intersection_of: RO:0002176 UBERON:0001979 ! connects venule intersection_of: RO:0002176 UBERON:0001980 ! connects arteriole relationship: RO:0002176 UBERON:0001979 ! connects venule relationship: RO:0002176 UBERON:0001980 ! connects arteriole property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/2/2f/A_red_blood_cell_in_a_capillary,_pancreatic_tissue_-_TEM.jpg" xsd:anyURI property_value: IAO:0000116 "not all sources agree capillary is a blood vessel - consider adopting EMAPA superclass of vascular element" xsd:string property_value: RO:0002175 NCBITaxon:9606 property_value: seeAlso "https://github.com/obophenotype/uberon/issues/2186" xsd:string property_value: skos:prefLabel "capillary" xsd:string [Term] id: UBERON:0001983 name: crypt of Lieberkuhn def: "The tubular intestinal glands found in the mucosal membranes." [https://github.com/obophenotype/uberon/issues/213, ISBN:0-683-40008-8, MP:0000490] subset: organ_slim subset: pheno_slim synonym: "crypt of Lieberkuhn" EXACT [] synonym: "crypt of Lieberkühn" EXACT [] synonym: "crypts of Lieberkühn" EXACT OMO:0003004 [] synonym: "follicles of Lieberkühn" EXACT [] synonym: "intestinal crypt" EXACT [] synonym: "intestinal crypts" EXACT OMO:0003004 [] synonym: "intestinal gland" BROAD [Wikipedia:Crypts_of_Lieberkuhn] synonym: "intestinal gland of Lieberkuhn" RELATED [FMA:63621] synonym: "Lieberkuhn crypt" EXACT [] synonym: "Lieberkuhn gland" EXACT [] synonym: "Lieberkuhn's gland" EXACT [] synonym: "Lieberkuhn's glands" EXACT OMO:0003004 [] synonym: "Lieberkühn crypt" EXACT [] xref: EMAPA:35266 xref: FMA:63621 xref: MA:0001535 xref: NCIT:C32411 xref: SCTID:118652008 xref: UMLS:C1621887 {source="ncithesaurus:Crypts_of_the_Lieberkuhn"} xref: Wikipedia:Intestinal_crypt is_a: UBERON:0000333 ! intestinal gland relationship: RO:0000086 PATO:0002299 {source="Wikipedia:Tubular_gland"} ! has quality tubular relationship: RO:0002162 NCBITaxon:32523 ! in taxon Tetrapoda relationship: RO:0002433 UBERON:0001242 ! contributes to morphology of intestinal mucosa property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/3/38/Small_intestine_low_mag.jpg" xsd:anyURI property_value: seeAlso UBERON:2005256 [Term] id: UBERON:0001984 name: crypt of Lieberkuhn of large intestine def: "A crypt of Lieberkühn that is part of a large intestine [Automatically generated definition]." [OBOL:automatic] subset: human_reference_atlas subset: pheno_slim synonym: "intestinal gland of large intestine" EXACT [OBOL:automatic] synonym: "large intestinal crypt of Lieberkuhn" EXACT [] synonym: "large intestine crypt of Lieberkuhn" EXACT [] synonym: "large intestine intestinal gland" EXACT [OBOL:automatic] synonym: "large intestine Lieberkühn crypt" EXACT [OBOL:automatic] synonym: "Lieberkühn crypt of large intestine" EXACT [OBOL:automatic] xref: EMAPA:35465 xref: FMA:63622 xref: MA:0001544 xref: NCIT:C32924 xref: UMLS:C1179777 {source="ncithesaurus:Large_Intestinal_Crypt_of_the_Lieberkuhn"} is_a: UBERON:0001983 ! crypt of Lieberkuhn intersection_of: UBERON:0001983 ! crypt of Lieberkuhn intersection_of: BFO:0000050 UBERON:0000059 ! part of large intestine relationship: BFO:0000050 UBERON:0001207 ! part of mucosa of large intestine relationship: RO:0002433 UBERON:0000059 ! contributes to morphology of large intestine property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001985 name: corneal endothelium def: "A monolayer of specialized, flattened, mitochondria-rich cells that lines the posterior surface of the cornea and faces the anterior chamber of the eye[WP]." [Wikipedia:Corneal_endothelium] subset: human_reference_atlas subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "cornea endothelium" EXACT [OBOL:automatic] synonym: "endothelium of cornea" EXACT [OBOL:automatic] synonym: "epithelium posterius corneae" RELATED OMO:0003011 [Wikipedia:Corneal_endothelium] xref: CALOHA:TS-0172 xref: EMAPA:35935 xref: FMA:63882 xref: GAID:891 xref: MA:0001242 xref: MESH:D004728 xref: NCIT:C12707 xref: SCTID:368827009 xref: TAO:0002186 xref: UMLS:C0014259 {source="ncithesaurus:Corneal_Endothelium"} xref: Wikipedia:Corneal_endothelium xref: ZFA:0001687 is_a: UBERON:0001986 ! endothelium is_a: UBERON:0010313 ! neural crest-derived structure is_a: UBERON:0010371 ! ecto-epithelium is_a: UBERON:0015808 ! eye epithelium intersection_of: UBERON:0001986 ! endothelium intersection_of: BFO:0000050 UBERON:0000964 ! part of cornea relationship: BFO:0000050 UBERON:0000964 ! part of cornea relationship: RO:0002220 UBERON:0001766 ! adjacent to anterior chamber of eyeball relationship: RO:0002433 UBERON:0000964 ! contributes to morphology of cornea property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/6/66/Gray871.png" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "corneal endothelium" xsd:string [Term] id: UBERON:0001986 name: endothelium def: "A layer of epithelium that lines the heart, blood vessels (endothelium, vascular), lymph vessels (endothelium, lymphatic), and the serous cavities of the body[MESH]. Simple squamous epithelium which lines blood and lymphatic vessels and the heart[FMA]." [FMA:63916, https://github.com/obophenotype/uberon/issues/225, MESH:A10.272.491] comment: The term 'endothelium' has been either restricted to the continuous cell layer of the vertebrates, as we are assuming here, or applied to all the cells able to adhere to the luminal surface of the vascular basement membrane (Casley-Smith 1980) subset: efo_slim subset: human_reference_atlas subset: uberon_slim xref: BTO:0000393 xref: CALOHA:TS-0278 xref: EFO:0002548 xref: FMA:63916 xref: GAID:520 xref: galen:Endothelium xref: MESH:D004727 xref: NCIT:C12481 xref: SCTID:27168002 xref: UMLS:C0014257 {source="ncithesaurus:Endothelium"} is_a: UBERON:0000487 {source="FMA-text-def", source="https://github.com/obophenotype/uberon/issues/225"} ! simple squamous epithelium is_a: UBERON:0012275 ! meso-epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: RO:0002473 CL:0000115 ! composed primarily of endothelial cell relationship: RO:0002162 NCBITaxon:7742 ! in taxon Vertebrata relationship: RO:0002473 CL:0000115 ! composed primarily of endothelial cell property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "endothelium" xsd:string [Term] id: UBERON:0001987 name: placenta def: "Organ of metabolic interchange between fetus and mother, partly of embryonic origin and partly of maternal origin[GO]. The fetal portion of the placenta is known as the villous chorion. The maternal portion is known as the decidua basalis. The two portions are held together by anchoring villi that are anchored to the decidua basalis by the cytotrophoblastic shell." [http://www.med.umich.edu/lrc/coursepages/m1/embryology/embryo/06placenta.htm, Wikipedia:Placenta] comment: Marsupials possess only a rudimentary yolk-type placenta, with reduced nutrient and oxygen exchanging capabilities. subset: efo_slim subset: human_reference_atlas subset: organ_slim subset: pheno_slim subset: uberon_slim synonym: "allantoic placenta" EXACT [ISBN:0073040584] synonym: "eutherian placenta" EXACT [] xref: BTO:0001078 xref: CALOHA:TS-0799 xref: EFO:0001407 xref: EMAPA:35689 xref: EV:0100119 xref: FMA:63934 xref: GAID:379 xref: MA:0000386 xref: MAT:0000279 xref: MESH:D010920 xref: MIAA:0000279 xref: NCIT:C13272 xref: SCTID:181455002 xref: UMLS:C0032043 {source="ncithesaurus:Placenta"} xref: VHOG:0001266 xref: Wikipedia:Placenta is_a: BFO:0000002 is_a: UBERON:0000062 ! organ is_a: UBERON:0005156 ! reproductive structure relationship: BFO:0000050 UBERON:0000474 ! part of female reproductive system relationship: BFO:0000050 UBERON:0016887 ! part of entire extraembryonic component relationship: RO:0002202 UBERON:0000995 {source="ISBN:0073040584"} ! develops from uterus relationship: RO:0002202 UBERON:0003124 {source="Wikipedia"} ! develops from chorion membrane relationship: RO:0002202 UBERON:0004340 {source="ISBN:0073040584"} ! develops from allantois property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/6/66/Placenta.jpg" xsd:anyURI property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/f/f1/Placenta.svg" xsd:anyURI property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/placenta-full-term-female/v1.1/assets/3d-vh-f-placenta-full-term.glb" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001988 name: feces def: "Portion of semisolid bodily waste discharged through the anus[MW,modified]." [http://www.merriam-webster.com/dictionary/feces, Wikipedia:Feces] subset: pheno_slim subset: uberon_slim synonym: "cow dung" NARROW [Wikipedia:Cow_dung] synonym: "cow pat" NARROW [Wikipedia:Cow_dung] synonym: "droppings" RELATED [] synonym: "dung" NARROW [] synonym: "excrement" RELATED [BTO:0000440] synonym: "excreta" BROAD [] synonym: "faeces" EXACT [] synonym: "fecal material" EXACT [] synonym: "fecal matter" EXACT [] synonym: "fewmet" NARROW [Wikipedia:Fewmet] synonym: "frass" NARROW [Wikipedia:Frass] synonym: "guano" NARROW [Wikipedia:Guano] synonym: "ordure" RELATED [] synonym: "piece of shit" EXACT [PMID:23285307] synonym: "portion of dung" NARROW [] synonym: "portion of excrement" EXACT [] synonym: "portion of faeces" EXACT [] synonym: "portion of fecal material" EXACT [] synonym: "portion of fecal matter" EXACT [] synonym: "portion of feces" EXACT [] synonym: "portion of guano" NARROW [] synonym: "portion of scat" NARROW [] synonym: "portionem cacas" EXACT OMO:0003011 [] synonym: "scat" NARROW [] synonym: "spoor" RELATED [] synonym: "spraint" NARROW [Wikipedia:Spraint] synonym: "stool" EXACT [] xref: BTO:0000440 xref: CALOHA:TS-2345 xref: ENVO:00002003 xref: FMA:64183 xref: GAID:1199 xref: galen:Feces xref: MA:0002509 xref: MAT:0000053 xref: MESH:D005243 xref: MIAA:0000053 xref: NCIT:C13234 xref: UMLS:C0015733 {source="ncithesaurus:Feces"} xref: Wikipedia:Feces is_a: UBERON:0000174 ! excreta intersection_of: UBERON:0000174 ! excreta intersection_of: RO:0002353 GO:0030421 ! output of defecation relationship: RO:0002353 GO:0030421 ! output of defecation property_value: skos:prefLabel "feces" xsd:string [Term] id: UBERON:0001989 name: superior cervical ganglion def: "Trunk ganglion which is bilaterally paired and located at the anterior end of the sympathetic ganglion chain." [Wikipedia:Superior_cervical_ganglion, ZFIN:curator] subset: efo_slim subset: human_reference_atlas subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "ganglion cervicale superius" RELATED OMO:0003011 [BTO:0001325, Wikipedia:Superior_cervical_ganglion] synonym: "SCG" RELATED OMO:0003000 [ZFA:0001572] synonym: "superior cervical sympathetic ganglion" EXACT [] synonym: "superior sympathetic cervical ganglion" RELATED [] xref: BAMS:GSC xref: BAMS:SCGn xref: BTO:0001325 xref: EFO:0001945 xref: EHDAA:8943 xref: EMAPA:18441 xref: FMA:6467 xref: GAID:712 xref: MA:0001156 xref: MESH:D017783 xref: NCIT:C92213 xref: RETIRED_EHDAA2:0001946 xref: SCTID:279278002 xref: TAO:0001572 xref: UMLS:C0206257 {source="ncithesaurus:Superior_Cervical_Ganglion"} xref: Wikipedia:Superior_cervical_ganglion xref: ZFA:0001572 is_a: UBERON:0001991 ! cervical ganglion property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/e/e1/Gray844.png" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001990 name: middle cervical ganglion def: "The small ganglion located at the level of the cricoid cartilage of the laryngeal wall." [ISBN:0-683-40008-8, MP:0001016] subset: human_reference_atlas subset: pheno_slim subset: uberon_slim synonym: "ganglion cervicale medium" RELATED OMO:0003011 [BTO:0000359, Wikipedia:Middle_cervical_ganglion] synonym: "middle cervical sympathetic ganglion" EXACT [] xref: BAMS:GMC xref: BTO:0000359 xref: EHDAA:8941 xref: EMAPA:18440 xref: FMA:6468 xref: MA:0001155 xref: NCIT:C92212 xref: RETIRED_EHDAA2:0001180 xref: SCTID:279279005 xref: UMLS:C0228999 {source="ncithesaurus:Middle_Cervical_Ganglion"} xref: Wikipedia:Middle_cervical_ganglion is_a: UBERON:0001991 ! cervical ganglion property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/e/e1/Gray844.png" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001991 name: cervical ganglion def: "The cervical ganglia are paravertebral ganglia of the sympathetic nervous system. They consist of three paravertebral ganglia: superior cervical ganglion middle cervical ganglion inferior cervical ganglion. The inferior ganglion may be fused with the first thoracic ganglion to form a single structure, the stellate ganglion. Nerves emerging from cervical sympathetic ganglia contribute to the cardiac plexus, among other things. [WP,unvetted]." [Wikipedia:Cervical_ganglion] subset: human_reference_atlas subset: uberon_slim synonym: "cervical sympathetic ganglion" EXACT [] xref: BTO:0000113 xref: EMAPA:18438 xref: FMA:6470 xref: MA:0001153 xref: SCTID:181100007 xref: Wikipedia:Cervical_ganglion is_a: UBERON:0001807 ! paravertebral ganglion property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/e/e1/Gray844.png" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001992 name: papillary layer of dermis def: "The upper layer of the dermis beneath the epidermis, composed of dense irregular connective tissue[ncit,modified]." [ncithesaurus:Papillary_Dermis] subset: pheno_slim subset: uberon_slim synonym: "corpus papillary" EXACT [MP:0009545] synonym: "dermal papillary layer" RELATED [EMAPA:35282] synonym: "dermis papillary layer" EXACT [MA:0000800] synonym: "papillary dermis" EXACT [] synonym: "papillary layer" EXACT [MP:0009545] synonym: "papillary layer of dermis" EXACT [FMA:64776] synonym: "stratum papillare" EXACT [MP:0009545] synonym: "stratum papillare" RELATED OMO:0003011 [Wikipedia:Papillary_dermis] synonym: "stratum papillare (dermis)" EXACT OMO:0003011 [FMA:64776, FMA:TA] synonym: "stratum papillare corii" EXACT [MP:0009545] synonym: "stratum papillare dermis" EXACT OMO:0003011 [FMA:64776, FMA:TA] synonym: "superficial dermis" EXACT [MA:0000802, MP:0009545] xref: EMAPA:35282 xref: FMA:64776 xref: MA:0000800 xref: MA:0000802 xref: NCIT:C33630 xref: NCIT:C94819 xref: UMLS:C0221930 {source="ncithesaurus:Stratum_Papillare"} xref: UMLS:C0682598 {source="ncithesaurus:Papillary_Dermis"} xref: Wikipedia:Papillary_dermis is_a: BFO:0000002 is_a: UBERON:0013754 ! integumentary system layer relationship: BFO:0000050 UBERON:0002067 ! part of dermis relationship: RO:0002473 UBERON:0006815 {source="WP"} ! composed primarily of areolar connective tissue relationship: RO:0002473 UBERON:0011822 {source="FMA-text"} ! composed primarily of dense irregular connective tissue property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/b/b4/Normal_Epidermis_and_Dermis_with_Intradermal_Nevus_10x.JPG" xsd:anyURI property_value: IAO:0000116 "todo - check tissue composition" xsd:string [Term] id: UBERON:0001993 name: reticular layer of dermis def: "The thicker, deeper layer of the dermis, comprised of criss-crossing collagen fibers that form a strong elastic network and also containing blood and lymph vessels, nerves and nerve endings, and hair follicles." [ISBN:0-683-40008-8, MP:0005081] subset: pheno_slim subset: uberon_slim synonym: "dermal reticular layer" RELATED [EMAPA:35283] synonym: "dermis reticular layer" EXACT [] synonym: "dermis stratum reticulare" EXACT [] synonym: "reticular dermis" EXACT [] synonym: "stratum reticulare" EXACT [Wikipedia:Reticular_dermis] synonym: "stratum reticulare" RELATED OMO:0003011 [Wikipedia:Reticular_dermis] synonym: "stratum reticulare dermis" EXACT OMO:0003011 [FMA:64778, FMA:TA] xref: EMAPA:35283 xref: FMA:64778 xref: MA:0000801 xref: NCIT:C33631 xref: NCIT:C94818 xref: UMLS:C0682599 {source="ncithesaurus:Reticular_Dermis"} xref: UMLS:C1514988 {source="ncithesaurus:Stratum_Reticulare"} xref: Wikipedia:Reticular_dermis is_a: UBERON:0013754 ! integumentary system layer relationship: BFO:0000050 UBERON:0002067 ! part of dermis relationship: BFO:0000050 UBERON:0008877 {source="FMA"} ! part of epidermal-dermal junction relationship: BSPO:0000107 UBERON:0001992 ! papillary layer of dermis relationship: RO:0002433 UBERON:0000014 ! contributes to morphology of zone of skin [Term] id: UBERON:0001994 name: hyaline cartilage tissue def: "Cartilage tissue primarily composed of type II collagen (thin fibrils) and a glassy appearance." [GO_REF:0000034, http://dx.plos.org/10.1371/journal.pone.0051070, PSPUB:0000170, VSAO:0000094] subset: pheno_slim subset: uberon_slim synonym: "chondroid cartilage" RELATED [http://orcid.org/0000-0002-6601-2165] synonym: "hyaline cartilage" EXACT [MA:0000109] xref: EMAPA:35414 xref: FMA:64783 xref: MA:0000109 xref: NCIT:C32746 xref: SCTID:39298000 xref: UMLS:C0225362 {source="ncithesaurus:Hyaline_Cartilage"} xref: VSAO:0000094 xref: Wikipedia:Hyaline_cartilage xref: XAO:0004029 is_a: UBERON:0002418 {source="FMA"} ! cartilage tissue relationship: RO:0002473 GO:0005585 {source="VSAO-text-def"} ! composed primarily of collagen type II trimer property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/2/2a/Gray292.png" xsd:anyURI property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/e/ee/Hypertrophic_Zone_of_Epiphyseal_Plate.jpg" xsd:anyURI property_value: skos:prefLabel "hyaline cartilage tissue" xsd:string [Term] id: UBERON:0001995 name: fibrocartilage def: "Cartilage tissue intermediate between hyaline cartilage and dense connective tissue; contains of abundant collagen fibers; chondrocytes often arranged in columns." [GO_REF:0000034, http://dx.plos.org/10.1371/journal.pone.0051070, PSPUB:0000170, VSAO:0000103] comment: The white fibrocartilages admit of arrangement into four groups-interarticular, connecting, circumferential, and stratiform -- WP. EDITOR NOTE: TODO add mineralized subset: pheno_slim subset: uberon_slim synonym: "fibrocartilage tissue" EXACT [http://orcid.org/0000-0002-6601-2165] synonym: "stratified cartilage tissue" EXACT [http://orcid.org/0000-0002-6601-2165] xref: FMA:64784 xref: galen:Fibrocartilage xref: MA:0000108 xref: NCIT:C32599 xref: SCTID:91685003 xref: UMLS:C0684077 {source="ncithesaurus:Fibrocartilage"} xref: VSAO:0000103 xref: Wikipedia:Fibrocartilage xref: XAO:0004028 is_a: UBERON:0002418 ! cartilage tissue relationship: BFO:0000051 GO:0005584 ! has part collagen type I trimer property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/2/2e/Gray295.png" xsd:anyURI [Term] id: UBERON:0001996 name: elastic cartilage tissue def: "Cartilage tissue that is flexible and contains abundant elastic fibers." [GO_REF:0000034, http://dx.plos.org/10.1371/journal.pone.0051070, PSPUB:0000170, VSAO:0000091] subset: pheno_slim subset: uberon_slim synonym: "elastic cartilage" EXACT [MA:0000107] synonym: "elastic cartilage tissue" EXACT [VSAO:0000091] synonym: "reticular cartilage" RELATED [http://orcid.org/0000-0002-6601-2165] synonym: "yellow cartilage" RELATED [http://orcid.org/0000-0002-6601-2165] synonym: "yellow elastic cartilage" EXACT [Wikipedia:Elastic_cartilage] synonym: "yellow elastic cartilage tissue" EXACT [] xref: FMA:64785 xref: MA:0000107 xref: MA:0000485 xref: NCIT:C32494 xref: UMLS:C0682559 {source="ncithesaurus:Elastic_Cartilage"} xref: VSAO:0000091 xref: Wikipedia:Elastic_cartilage xref: XAO:0004197 is_a: UBERON:0011589 {source="VSAO"} ! non-mineralized cartilage tissue relationship: BFO:0000051 GO:0071953 {source="Wikipedia"} ! has part elastic fiber relationship: RO:0000086 PATO:0001544 ! has quality flexible relationship: RO:0002202 UBERON:0005863 {source="VSAO"} ! develops from cartilaginous condensation property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/c/ca/Gray904.png" xsd:anyURI [Term] id: UBERON:0001997 name: olfactory epithelium def: "A sensory epithelium inside the nasal cavity that is responsible for detecting odors[WP]." [Wikipedia:Olfactory_epithelium] comment: Genes: V1Rs, Trpc2 present in lamprey subset: efo_slim subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "main olfactory epithelium" EXACT [NCBIBook:NBK55971] synonym: "MOE" RELATED OMO:0003000 [NCBIBook:NBK55971] synonym: "nasal cavity olfactory epithelium" EXACT [MA:0001325] synonym: "nasal epithelium" RELATED [] synonym: "nasal sensory epithelium" RELATED [] synonym: "olfactory membrane" EXACT [BIRNLEX:2703] synonym: "olfactory sensory epithelium" EXACT [] synonym: "pseudostratified main olfactory epithelium" RELATED [http://www.ncbi.nlm.nih.gov/books/NBK55971/] synonym: "sensory olfactory epithelium" EXACT [] xref: AAO:0010158 xref: BIRNLEX:2703 xref: BTO:0000108 xref: CALOHA:TS-0703 xref: EFO:0001972 xref: EHDAA2:0001228 xref: EHDAA:4774 xref: EMAPA:17606 xref: FMA:64803 xref: MA:0001325 xref: MAT:0000445 xref: NCIT:C33203 xref: neuronames:1900 {source="BIRNLEX:2703"} xref: SCTID:37623003 xref: TAO:0000554 xref: UMLS:C0599332 {source="BIRNLEX:2703", source="ncithesaurus:Olfactory_Epithelium"} xref: VHOG:0000985 xref: Wikipedia:Olfactory_epithelium xref: ZFA:0000554 is_a: UBERON:0005384 ! nasal cavity epithelium is_a: UBERON:0006934 ! sensory epithelium is_a: UBERON:0010371 ! ecto-epithelium intersection_of: UBERON:0006934 ! sensory epithelium intersection_of: BFO:0000050 UBERON:0005386 ! part of olfactory segment of nasal mucosa relationship: BFO:0000050 UBERON:0000012 {source="NIFSTD"} ! part of somatic nervous system relationship: BFO:0000050 UBERON:0005386 ! part of olfactory segment of nasal mucosa relationship: BFO:0000051 CL:0000207 {source="NBK26868"} ! has part olfactory receptor cell relationship: BFO:0000051 CL:0000853 {source="NBK26868"} ! has part olfactory epithelial supporting cell relationship: BFO:0000051 CL:0002169 {source="NBK26868"} ! has part basal cell of olfactory epithelium relationship: RO:0002216 GO:0050911 ! capable of part of detection of chemical stimulus involved in sensory perception of smell relationship: RO:0002433 UBERON:0005725 ! contributes to morphology of olfactory system relationship: RO:0002495 UBERON:2001431 ! immediate transformation of primitive olfactory epithelium relationship: site_of GO:0022008 {source="NCBIBook:NBK55982"} ! neurogenesis property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/4/4d/Gray857.png" xsd:anyURI property_value: skos:prefLabel "olfactory epithelium" xsd:string [Term] id: UBERON:0002001 name: joint of rib def: "Any joint that connects a rib to another structure (or another rib). Examples: costochondral, costovertebral, interchondral, sternocostal joints." [https://orcid.org/0000-0002-6601-2165] synonym: "rib joint" EXACT [] xref: FMA_RETIRED:64994 xref: MA:0001508 xref: NCIT:C49575 xref: SCTID:263314001 xref: UMLS:C1261194 {source="ncithesaurus:Joint_of_the_Rib"} is_a: UBERON:0000982 ! skeletal joint intersection_of: UBERON:0000982 ! skeletal joint intersection_of: RO:0002176 UBERON:0002228 ! connects rib relationship: BFO:0000050 UBERON:0014478 {source="cjm"} ! part of rib skeletal system relationship: RO:0002176 UBERON:0002228 ! connects rib [Term] id: UBERON:0002004 name: trunk of sciatic nerve synonym: "sciatic nerve trunk" EXACT [] synonym: "sciatic neural trunk" EXACT [] xref: FMA:65507 xref: MA:0001178 is_a: UBERON:0002464 ! nerve trunk intersection_of: UBERON:0002464 ! nerve trunk intersection_of: BFO:0000050 UBERON:0001322 ! part of sciatic nerve relationship: BFO:0000050 UBERON:0001322 ! part of sciatic nerve [Term] id: UBERON:0002005 name: enteric nervous system def: "The enteric nervous system is composed of two ganglionated neural plexuses in the gut wall which form one of the three major divisions of the autonomic nervous system. The enteric nervous system innervates the gastrointestinal tract, the pancreas, and the gall bladder. It contains sensory neurons, interneurons, and motor neurons. Thus the circuitry can autonomously sense the tension and the chemical environment in the gut and regulate blood vessel tone, motility, secretions, and fluid transport. The system is itself governed by the central nervous system and receives both parasympathetic and sympathetic innervation[GO]." [GO:0048484] subset: efo_slim subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "enteric PNS" EXACT [EFO:0000895] synonym: "PNS - enteric" EXACT [EFO:0000895] xref: BAMS:ENS xref: BIRNLEX:1166 xref: BTO:0002506 xref: CALOHA:TS-2093 xref: EFO:0000895 xref: EHDAA2:0004202 xref: EMAPA:26922 xref: FMA:66070 xref: GAID:799 xref: MA:0000222 xref: MAT:0000102 xref: MESH:D017615 xref: MIAA:0000102 xref: TAO:0001155 xref: UMLS:C0206111 {source="BIRNLEX:1166"} xref: Wikipedia:Enteric_nervous_system xref: ZFA:0001155 is_a: BFO:0000002 is_a: UBERON:0011216 {source="cjm"} ! organ system subdivision relationship: BFO:0000050 UBERON:0002410 {source="FMA", source="MA", source="NIF", source="ZFA-isa-changed"} ! part of autonomic nervous system relationship: RO:0002202 UBERON:0005428 {source="Wikipedia", source="ZFA", source="https://github.com/obophenotype/uberon/wiki/The-neural-crest"} ! develops from vagal neural crest relationship: RO:0002433 UBERON:0002410 ! contributes to morphology of autonomic nervous system [Term] id: UBERON:0002006 name: cortex of lymph node def: "Peripheral portion of the lymph node, underneath the capsule[WP]." [Wikipedia:Cortex_of_lymph_node] subset: human_reference_atlas subset: pheno_slim subset: uberon_slim synonym: "cortex nodi lymphoidei" RELATED OMO:0003011 [Wikipedia:Cortex_of_lymph_node] synonym: "lymph node cortex" EXACT [] xref: EMAPA:35525 xref: FMA:66253 xref: MA:0000740 xref: NCIT:C33029 xref: UMLS:C0933402 {source="ncithesaurus:Lymph_Node_Cortex"} xref: Wikipedia:Cortex_of_lymph_node is_a: UBERON:0001851 ! cortex intersection_of: UBERON:0001851 ! cortex intersection_of: BFO:0000050 UBERON:0000029 ! part of lymph node relationship: BFO:0000050 UBERON:0000029 ! part of lymph node relationship: RO:0002220 UBERON:0002194 ! adjacent to capsule of lymph node property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/b/b8/Illu_lymph_node_structure.png" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0002007 name: medulla of lymph node def: "The medullary portion of the lymph node, which contains large blood vessels, sinuses and medullary cords that contain antibody-secreting plasma cells." [http://orcid.org/0000-0002-6601-2165, Wikipedia:Lymph_node#Medulla] subset: human_reference_atlas subset: pheno_slim subset: uberon_slim synonym: "lymph node medulla" EXACT [] synonym: "medulla nodi lymphoidei" RELATED OMO:0003011 [Wikipedia:Medulla_of_lymph_node] xref: EMAPA:35529 xref: FMA:66254 xref: MA:0000745 is_a: UBERON:0000958 ! medulla of organ intersection_of: UBERON:0000958 ! medulla of organ intersection_of: BFO:0000050 UBERON:0000029 ! part of lymph node relationship: BFO:0000050 UBERON:0000029 ! part of lymph node relationship: BFO:0000051 UBERON:0009744 ! has part lymph node medullary sinus relationship: BFO:0000051 UBERON:0009745 ! has part lymph node medullary cord property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/lymph-node-female/v1.4/assets/3d-nih-f-lymph-node.glb" xsd:anyURI property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/lymph-node-male/v1.4/assets/3d-nih-m-lymph-node.glb" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0002008 name: cardiac nerve plexus def: "A plexus of nerves situated at the base of the heart that innervate the heart." [Wikipedia:Cardiac_plexus] subset: uberon_slim synonym: "autonomic nerve plexus of heart" EXACT [OBOL:automatic] synonym: "autonomic plexus of heart" EXACT [OBOL:automatic] synonym: "cardiac plexus" EXACT [] synonym: "heart autonomic nerve plexus" EXACT [OBOL:automatic] synonym: "heart autonomic plexus" EXACT [OBOL:automatic] synonym: "plexus cardiacus" EXACT OMO:0003011 [Wikipedia:Cardiac_plexus] xref: EMAPA:37460 {source="MA:th"} xref: FMA:6628 xref: MA:0001138 xref: NCIT:C52833 xref: SCTID:280511002 xref: UMLS:C0459528 {source="ncithesaurus:Cardiac_Nerve_Plexus"} xref: Wikipedia:Cardiac_plexus is_a: UBERON:0000122 ! neuron projection bundle is_a: UBERON:0001816 ! autonomic nerve plexus intersection_of: UBERON:0001816 ! autonomic nerve plexus intersection_of: RO:0002134 UBERON:0000948 ! innervates heart relationship: RO:0002134 UBERON:0000948 ! innervates heart property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/7/77/Gray838.png" xsd:anyURI [Term] id: UBERON:0002010 name: celiac nerve plexus def: "A complex network of nerves located in the abdomen behind the stomach. The celiac plexus is located near where the celiac trunk, superior mesenteric artery, and renal arteries branch from the abdominal aorta. It is behind the stomach and the omental bursa and in front of the crura of the diaphragm, on the level of the first lumbar vertebra, L1. The plexus is formed (in part) by the greater and lesser splanchnic nerves of both sides, and also parts of the right vagus nerve. The celiac plexus proper consists of the celiac ganglia with a network of interconnecting fibers. The aorticorenal ganglia are often considered to be part of the celiac ganglia, and thus, part of the plexus. [WP,unvetted]." [Wikipedia:Celiac_plexus] subset: uberon_slim synonym: "celiac plexus" EXACT [] synonym: "coeliac nerve plexus" RELATED [] synonym: "coeliac plexus" EXACT [] synonym: "plexus coeliacus" EXACT OMO:0003011 [FMA:6630, FMA:TA] synonym: "plexus coeliacus" RELATED OMO:0003011 [Wikipedia:Celiac_plexus] synonym: "plexus nervosus coeliacus" EXACT OMO:0003011 [FMA:6630, FMA:TA] synonym: "solar plexus" RELATED [MESH:A08.800.050.050.150] xref: EMAPA:37461 {source="MA:th"} xref: FMA:6630 xref: GAID:796 xref: MA:0001139 xref: MESH:D002447 xref: SCTID:362494009 xref: Wikipedia:Celiac_plexus is_a: UBERON:0001816 ! autonomic nerve plexus relationship: BFO:0000050 UBERON:0000916 ! part of abdomen property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/7/77/Gray838.png" xsd:anyURI [Term] id: UBERON:0002011 name: thoracodorsal artery def: "The thoracodorsal artery is a branch of the subscapular artery. It travels inferiorly with the thoracodorsal nerve and supplies the latissimus dorsi. [WP,unvetted]." [Wikipedia:Thoracodorsal_artery] subset: human_reference_atlas subset: uberon_slim synonym: "arteria thoracodorsalis" RELATED OMO:0003011 [Wikipedia:Thoracodorsal_artery] xref: EMAPA:37129 {source="MA:th"} xref: FMA:66320 xref: MA:0002065 xref: NCIT:C53018 xref: UMLS:C0933449 {source="ncithesaurus:Thoracodorsal_Artery"} xref: Wikipedia:Thoracodorsal_artery is_a: UBERON:0001637 ! artery intersection_of: UBERON:0001637 ! artery intersection_of: RO:0020101 UBERON:0001112 ! vessel supplies blood to latissimus dorsi muscle relationship: RO:0002170 UBERON:0001397 ! connected to subscapular artery relationship: RO:0020101 UBERON:0001112 ! vessel supplies blood to latissimus dorsi muscle property_value: foaf:depiction "https://upload.wikimedia.org/wikipedia/commons/7/7d/Latissimus_dorsi.png" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0002012 name: pulmonary artery def: "An artery that carries deoxygenated blood from heart to the lungs. They are the only arteries (other than umbilical arteries in the fetus) that carry deoxygenated blood.." [http://orcid.org/0000-0002-6601-2165, Wikipedia:Pulmonary_artery] subset: efo_slim subset: human_reference_atlas subset: pheno_slim subset: uberon_slim synonym: "arteria pulmonalis" RELATED OMO:0003011 [Wikipedia:Pulmonary_artery] synonym: "pulmonary arterial subtree" RELATED [FMA:66326] synonym: "pulmonary arterial tree" EXACT [FMA:66326] synonym: "pulmonary arterial tree organ part" EXACT [FMA:66326] synonym: "truncus pulmonalis" RELATED OMO:0003011 [Wikipedia:Pulmonary_artery] xref: AAO:0010221 xref: BTO:0000778 xref: CALOHA:TS-0839 xref: EFO:0001399 xref: EHDAA2:0001575 xref: EHDAA:4351 xref: EMAPA:17008 xref: FMA:66326 xref: GAID:505 xref: galen:PulmonaryArtery xref: MA:0002031 xref: MESH:D011651 xref: NCIT:C12774 xref: SCTID:181380003 xref: UMLS:C0034052 {source="ncithesaurus:Pulmonary_Artery"} xref: VHOG:0000982 xref: Wikipedia:Pulmonary_artery xref: XAO:0004162 is_a: UBERON:0001637 ! artery is_a: UBERON:0013768 ! great vessel of heart intersection_of: UBERON:0001637 ! artery intersection_of: BFO:0000050 UBERON:0008886 ! part of pulmonary vascular system intersection_of: RO:0020101 UBERON:0002048 ! vessel supplies blood to lung disjoint_from: UBERON:0004573 ! systemic artery relationship: BFO:0000050 UBERON:0008886 ! part of pulmonary vascular system relationship: RO:0002150 UBERON:0002333 ! continuous with pulmonary trunk relationship: RO:0002202 UBERON:0002061 {source="Wikipedia"} ! develops from truncus arteriosus relationship: RO:0002202 UBERON:0003123 {source="EHDAA2", source="XAO"} ! develops from pharyngeal arch artery 6 relationship: RO:0002202 UBERON:0005339 {source="EHDAA2"} ! develops from outflow tract pulmonary component relationship: RO:0020101 UBERON:0002048 ! vessel supplies blood to lung property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/blood-vasculature-female/v1.3/assets/3d-vh-f-blood-vasculature.glb" xsd:anyURI property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/blood-vasculature-male/v1.3/assets/3d-vh-m-blood-vasculature.glb" xsd:anyURI property_value: foaf:depiction "https://upload.wikimedia.org/wikipedia/commons/d/db/Alveoli_diagram.png" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "pulmonary artery" xsd:string [Term] id: UBERON:0002015 name: kidney capsule def: "The tough fibrous layer surrounding the kidney which is covered in a thick layer of perirenal adipose tissue that functions to provide some protection from trauma and damage." [MGI:anna, MP:0011383] subset: human_reference_atlas subset: pheno_slim subset: uberon_slim synonym: "capsula fibrosa renis" EXACT OMO:0003011 [FMA:66610, FMA:TA] synonym: "capsule of kidney" EXACT [] synonym: "fibrous capsule of kidney" EXACT [FMA:66610] synonym: "renal capsule" EXACT [GO:0072127] xref: EMAPA:18679 xref: FMA:66610 xref: galen:CapsuleOfKidney xref: MA:0000370 xref: NCIT:C12885 xref: SCTID:243657006 xref: UMLS:C0227637 {source="ncithesaurus:Renal_Capsule"} xref: Wikipedia:Kidney_capsule is_a: UBERON:0003567 ! abdomen connective tissue is_a: UBERON:0011824 ! fibrous connective tissue intersection_of: UBERON:0011824 ! fibrous connective tissue intersection_of: RO:0002007 UBERON:0002113 ! bounding layer of kidney relationship: RO:0002007 UBERON:0002113 ! bounding layer of kidney relationship: RO:0002433 UBERON:0002113 ! contributes to morphology of kidney property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/kidney-female-left/v1.3/assets/3d-vh-f-kidney-l.glb" xsd:anyURI property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/kidney-female-right/v1.3/assets/3d-vh-f-kidney-r.glb" xsd:anyURI property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/kidney-male-left/v1.3/assets/3d-vh-m-kidney-l.glb" xsd:anyURI property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/kidney-male-right/v1.3/assets/3d-vh-m-kidney-r.glb" xsd:anyURI property_value: foaf:depiction "https://upload.wikimedia.org/wikipedia/commons/6/69/Illu_kidney.jpg" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0002016 name: pulmonary vein def: "Pulmonary veins are blood vessels that transport blood from the lungs to the heart[GO]." [GO:0060577] subset: human_reference_atlas subset: pheno_slim subset: uberon_slim synonym: "pulmonary venous tree organ part" EXACT [] synonym: "venae pulmonales" RELATED OMO:0003011 [Wikipedia:Pulmonary_vein] xref: AAO:0010521 xref: BTO:0001799 xref: CALOHA:TS-0840 xref: EHDAA2:0001579 xref: EHDAA:2629 xref: EMAPA:18645 xref: FMA:66643 xref: GAID:543 xref: galen:PulmonaryVein xref: MA:0002206 xref: MESH:D011667 xref: NCIT:C12776 xref: SCTID:430160002 xref: UMLS:C0034090 {source="ncithesaurus:Pulmonary_Vein"} xref: VHOG:0001133 xref: Wikipedia:Pulmonary_vein xref: XAO:0000394 is_a: UBERON:0001638 ! vein is_a: UBERON:0013768 ! great vessel of heart intersection_of: UBERON:0001638 ! vein intersection_of: RO:0020102 UBERON:0002048 ! vessel drains blood from lung relationship: BFO:0000050 UBERON:0008886 ! part of pulmonary vascular system relationship: RO:0002170 UBERON:0002079 ! connected to left cardiac atrium relationship: RO:0002202 UBERON:0002061 ! develops from truncus arteriosus relationship: RO:0020102 UBERON:0002048 ! vessel drains blood from lung property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/blood-vasculature-female/v1.3/assets/3d-vh-f-blood-vasculature.glb" xsd:anyURI property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/blood-vasculature-male/v1.3/assets/3d-vh-m-blood-vasculature.glb" xsd:anyURI property_value: foaf:depiction "https://upload.wikimedia.org/wikipedia/commons/d/db/Alveoli_diagram.png" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "pulmonary vein" xsd:string [Term] id: UBERON:0002017 name: portal vein def: "A vein that conducts blood from the digestive organs, spleen, pancreas, and gallbladder to the liver[BTO]." [BTO:0001792] subset: pheno_slim subset: uberon_slim synonym: "portal venous tree organ part" EXACT [FMA:66645] xref: BTO:0001792 xref: CALOHA:TS-0814 xref: EHDAA2:0001485 xref: EHDAA:6510 xref: EMAPA:17349 xref: FMA:66645 xref: GAID:540 xref: galen:PortalVein xref: MA:0002198 xref: MESH:D011169 xref: NCIT:C33343 xref: SCTID:362064007 xref: UMLS:C0032718 {source="ncithesaurus:Portal_Vein"} xref: VHOG:0000656 xref: XAO:0000392 is_a: UBERON:0001638 {source="FMA"} ! vein relationship: BFO:0000050 UBERON:0005806 ! part of portal system property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/3/33/Gray591.png" xsd:anyURI property_value: skos:prefLabel "portal vein" xsd:string [Term] id: UBERON:0002018 name: synovial membrane of synovial joint def: "Soft tissue that lines the non-cartilaginous surfaces within joints with cavities (synovial joints)." [Wikipedia:Synovial_membrane] subset: efo_slim subset: uberon_slim synonym: "membrana synovialis (capsula articularis)" EXACT OMO:0003011 [FMA:9865, FMA:TA] synonym: "membrana synovialis capsulae articularis" EXACT OMO:0003011 [Wikipedia:Synovial_membrane] synonym: "stratum synoviale" EXACT OMO:0003011 [FMA:66762, FMA:TA] synonym: "stratum synoviale (capsula articularis)" EXACT OMO:0003011 [FMA:9865, FMA:TA] synonym: "synovial layer" BROAD [FMA:66762] synonym: "synovial layer of articular capsule of synovial joint" RELATED [FMA:9865] synonym: "synovial membrane" BROAD [AEO:0000181] synonym: "synovial membrane of articular capsule of synovial joint" RELATED [FMA:9865] synonym: "synovium" BROAD [BTO:0001823, VHOG:0001282] synonym: "synovium of articular capsule of synovial joint" RELATED [FMA:9865] xref: AEO:0000181 xref: BTO:0001823 xref: EFO:0001393 xref: EHDAA2_RETIRED:0003181 xref: EMAPA:37476 {source="MA:th"} xref: EV:0100143 xref: FMA:9865 xref: GAID:264 xref: galen:SynovialMembrane xref: MA:0000114 xref: MESH:D013583 xref: NCIT:C12473 xref: SCTID:361828005 xref: UMLS:C0039099 {source="ncithesaurus:Synovial_Membrane"} xref: VHOG:0001282 xref: Wikipedia:Synovial_membrane is_a: UBERON:0007616 {source="FMA"} ! layer of synovial tissue relationship: BFO:0000050 UBERON:0002217 {source="EHDAA2"} ! part of synovial joint relationship: BFO:0000051 CL:0000214 ! has part synovial cell relationship: RO:0002371 UBERON:0001484 {source="GAID"} ! attached to articular capsule property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/1/19/Joint.png" xsd:anyURI property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/5/5d/Synovium.png" xsd:anyURI [Term] id: UBERON:0002019 name: accessory XI nerve def: "A cranial nerve that originates from neurons in the medulla and in the cervical spinal cord." [BIRNLEX:812, http://orcid.org/0000-0002-6601-2165] subset: pheno_slim subset: uberon_slim synonym: "accessory nerve" EXACT [] synonym: "accessory nerve [XI]" EXACT [] synonym: "accessory spinal nerve" RELATED [BAMS:XIn] synonym: "accessory XI" EXACT [EHDAA2:0000106] synonym: "accessory XI nerve" EXACT [] synonym: "cervical accessory nerve" EXACT [] synonym: "CN-XI" RELATED [VHOG:0000699] synonym: "cranial nerve XI" EXACT [BIRNLEX:812] synonym: "eleventh cranial nerve" EXACT [BIRNLEX:812] synonym: "nervus accessorius [XI]" EXACT OMO:0003011 [FMA:6720, FMA:TA] synonym: "pars spinalis nervus accessorius" EXACT OMO:0003011 [FMA:6720, FMA:TA] synonym: "radix spinalis nervus accessorius" EXACT OMO:0003011 [FMA:6720, FMA:TA] synonym: "spinal accessory nerve" EXACT [FMA:6720] synonym: "spinal accessory nerve tree" EXACT [] synonym: "spinal part of accessory nerve" EXACT [] synonym: "Willis' nerve" EXACT [] xref: AAO:0010476 xref: BAMS:11n xref: BAMS:XIn xref: BIRNLEX:812 xref: EHDAA2:0000106 xref: EHDAA:2855 xref: EMAPA:17265 xref: FMA:6720 xref: FMA:80284 xref: GAID:825 xref: MA:0001088 xref: MBA:717 xref: MESH:D000055 xref: NCIT:C32041 xref: neuronames:2085 xref: SCTID:362469008 xref: UMLS:C0000905 {source="ncithesaurus:Accessory_Nerve", source="BIRNLEX:812"} xref: UMLS:C1305777 {source="BIRNLEX:812"} xref: VHOG:0000699 xref: Wikipedia:Spinal_accessory_nerve xref: XAO:0004214 is_a: UBERON:0035642 ! laryngeal nerve intersection_of: UBERON:0001021 ! nerve intersection_of: extends_fibers_into UBERON:0020358 ! accessory XI nerve nucleus relationship: extends_fibers_into UBERON:0020358 ! accessory XI nerve nucleus property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/5/5e/Gray791.png" xsd:anyURI property_value: skos:prefLabel "accessory XI nerve" xsd:string [Term] id: UBERON:0002020 name: gray matter def: "A nervous system structure composed primarily of nerve cell bodies (somas). May also include dendrites and the initial unmyelinated portion of axons." [http://orcid.org/0000-0002-6601-2165, Wikipedia:Gray_matter] subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "gray mater" RELATED [ZFA:0001681] synonym: "gray matter" EXACT [] synonym: "gray matter of neuraxis" EXACT [FMA:67242] synonym: "grey matter" EXACT [] synonym: "grey matter of neuraxis" EXACT [] synonym: "grey substance" EXACT [] synonym: "grisea" RELATED OMO:0003011 [] synonym: "neuronal grey matter" EXACT [AEO:0001012] synonym: "substantia grisea" EXACT OMO:0003011 [FMA:67242, FMA:TA] xref: AEO:0001012 xref: EHDAA2:0003136 xref: EHDAA2_RETIRED:0004658 xref: EMAPA:37596 {source="MA:th"} xref: FMA:67242 xref: HBA:4006 xref: MA:0001112 xref: NCIT:C32695 xref: neuronames:2869 xref: TAO:0002197 xref: UMLS:C0018220 {source="ncithesaurus:Gray_Matter"} xref: VHOG:0001768 xref: Wikipedia:Gray_matter xref: ZFA:0001681 is_a: UBERON:0011215 ! central nervous system cell part cluster relationship: RO:0002473 GO:0043025 ! composed primarily of neuronal cell body property_value: foaf:depiction "https://upload.wikimedia.org/wikipedia/commons/d/d2/Spinal_nerve.svg" xsd:anyURI property_value: skos:prefLabel "gray matter" xsd:string [Term] id: UBERON:0002025 name: stratum basale of epidermis def: "The deepest layer of the epidermis, which is composed of dividing stem cells and anchoring cells." [ISBN:0-683-40008-8, MP:0001231] subset: human_reference_atlas subset: pheno_slim subset: uberon_slim synonym: "basal cell layer of epidermis" EXACT [FMA:67540] synonym: "basal cell layer of skin" RELATED [] synonym: "basal epidermal layer" EXACT [ZFA:0001180] synonym: "basal layer of epidermis" RELATED [] synonym: "epidermal basal stratum" EXACT [TAO:0001180] synonym: "epidermis basal layer" RELATED [] synonym: "epidermis sensorial layer" RELATED [XAO:0000041] synonym: "epidermis stratum basale" EXACT [] synonym: "epidermis stratum germinativum" RELATED [] synonym: "Malpighian layer" BROAD [Wikipedia:Malpighian_layer] synonym: "rete Malphighii" BROAD MISSPELLING [] synonym: "rete Malpighii" BROAD [] synonym: "stratum basale" BROAD [] synonym: "stratum basalis of epidermis" EXACT [] synonym: "stratum germinativum" EXACT [] synonym: "stratum germinosum" BROAD [] synonym: "stratum germinosum of epidermis" EXACT [] synonym: "stratum Malpighi" BROAD OMO:0003011 [Wikipedia:Malpighian_layer] xref: AAO:0010598 xref: BTO:0000438 xref: EMAPA:32779 xref: FMA:67540 xref: MA:0000803 xref: NCIT:C33466 xref: NCIT:C33623 xref: SCTID:419481005 xref: TAO:0001180 xref: UMLS:C0221925 {source="ncithesaurus:Stratum_Basale"} xref: Wikipedia:Stratum_germinativum xref: XAO:0000041 xref: ZFA:0001180 is_a: BFO:0000002 is_a: UBERON:0013754 ! integumentary system layer intersection_of: UBERON:0013754 ! integumentary system layer intersection_of: RO:0002473 CL:0002187 ! composed primarily of basal cell of epidermis relationship: BFO:0000050 UBERON:0001003 ! part of skin epidermis relationship: BFO:0000051 CL:0000148 ! has part melanocyte relationship: BFO:0000051 CL:0000242 ! has part Merkel cell relationship: RO:0002473 CL:0002187 ! composed primarily of basal cell of epidermis property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0002026 name: stratum spinosum of epidermis def: "The layer of polyhedral cells in the epidermis found between the stratum granulosum and stratum basale; shrinkage and adhesion of these cells gives a spiny or prickly appearance." [ISBN:0-683-40008-8, MP:0001236] subset: human_reference_atlas subset: pheno_slim synonym: "epidermis prickle cell layer" RELATED [] synonym: "epidermis stratum spinosum" EXACT [] synonym: "Malpighian layer" BROAD [Wikipedia:Malpighian_layer] synonym: "prickle cell layer" RELATED [BTO:0000435] synonym: "prickle cell layer of epidermis" EXACT [FMA:67542] synonym: "squamous cell layer of epidermis" EXACT [] synonym: "stratum Malpighii" BROAD OMO:0003011 [Wikipedia:Malpighian] synonym: "stratum spinosum" EXACT [] xref: BTO:0000435 xref: EMAPA:32785 xref: FMA:67542 xref: MA:0000807 xref: NCIT:C12850 xref: SCTID:420086000 xref: UMLS:C0221924 {source="ncithesaurus:Stratum_Spinosum"} xref: Wikipedia:Stratum_spinosum is_a: BFO:0000002 is_a: UBERON:0013754 ! integumentary system layer intersection_of: UBERON:0013754 ! integumentary system layer intersection_of: RO:0002473 CL:0000649 ! composed primarily of spinous cell of epidermis relationship: BFO:0000050 UBERON:0001003 ! part of skin epidermis relationship: BFO:0000051 CL:0000453 ! has part Langerhans cell relationship: RO:0002220 UBERON:0002025 ! adjacent to stratum basale of epidermis relationship: RO:0002220 UBERON:0002069 ! adjacent to stratum granulosum of epidermis relationship: RO:0002473 CL:0000649 ! composed primarily of spinous cell of epidermis property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0002027 name: stratum corneum of epidermis def: "The outer layer of the epidermis, consisting of several layers of flat keratinized non-nucleated cells." [ISBN:0-683-40008-8, MP:0001240] subset: human_reference_atlas subset: pheno_slim synonym: "cornified layer" EXACT [] synonym: "epidermis stratum corneum" EXACT [] synonym: "horny layer" BROAD [BTO:0000344] synonym: "horny layer of epidermis" EXACT [FMA:67545] synonym: "keratinized squame layer" BROAD [] synonym: "keratinized squame layer of epidermis" EXACT [] synonym: "stratum corneum" BROAD [] synonym: "stratum corneum epidermidis" RELATED OMO:0003011 [Wikipedia:Stratum_corneum] xref: AAO:0010597 xref: BTO:0000344 xref: CALOHA:TS-0981 xref: EMAPA:32787 xref: FMA:67545 xref: MA:0000804 xref: NCIT:C33625 xref: SCTID:361695002 xref: UMLS:C0221921 {source="ncithesaurus:Stratum_Corneum"} xref: Wikipedia:Stratum_corneum is_a: BFO:0000002 is_a: UBERON:0013754 ! integumentary system layer relationship: BFO:0000050 UBERON:0001003 ! part of skin epidermis relationship: BFO:0000051 CL:0002153 {source="FMA"} ! has part corneocyte relationship: BFO:0000067 GO:0031424 ! contains process keratinization relationship: BSPO:0000108 UBERON:0002069 ! stratum granulosum of epidermis property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/2/20/Skinlayers.png" xsd:anyURI property_value: foaf:depiction "https://upload.wikimedia.org/wikipedia/commons/e/e4/Epidermal_layers.png" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0002028 name: hindbrain def: "The most posterior of the three principal regions of the brain. In mammals and birds the hindbrain is divided into a rostral metencephalon and a caudal myelencephalon. In zebrafish, with the exception of the cerebellum, the ventral remainder of the metencephalon can be separated only arbitrarily from the more caudal myelencephalic portion of the medulla oblongata (From: Neuroanatomy of the Zebrafish Brain)[ZFA]. Organ component of neuraxis that has as its parts the pons, cerebellum and medulla oblongata[FMA]." [Wikipedia:Rhombencephalon, ZFA:0000029, ZFIN:curator] subset: efo_slim subset: human_reference_atlas subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "rhombencephalon" RELATED [] xref: AAO:0010150 xref: BAMS:HB xref: BIRNLEX:942 xref: BTO:0000672 xref: CALOHA:TS-0457 xref: DHBA:10653 xref: DMBA:16808 xref: EFO:0000923 xref: EHDAA2:0000746 xref: EHDAA:3514 xref: EHDAA:6487 xref: EMAPA:16916 xref: FMA:67687 xref: MA:0000195 xref: MAT:0000107 xref: MBA:1065 xref: MESH:D012249 xref: MIAA:0000107 xref: NCIT:C40336 xref: neuronames:540 {source="BIRNLEX:942"} xref: SCTID:303456008 xref: TAO:0000029 xref: UMLS:C0035507 {source="ncithesaurus:Hind-Brain", source="BIRNLEX:942"} xref: UMLS:C1522180 {source="BIRNLEX:942"} xref: VHOG:0000070 xref: Wikipedia:Rhombencephalon xref: XAO:0000015 xref: ZFA:0000029 is_a: UBERON:0002616 ! regional part of brain is_a: UBERON:0004121 ! ectoderm-derived structure relationship: RO:0002131 UBERON:0002298 ! overlaps brainstem relationship: RO:0002433 UBERON:0000955 ! contributes to morphology of brain relationship: RO:0002495 UBERON:0007277 {source="Bgee:AN"} ! immediate transformation of presumptive hindbrain property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/5/54/EmbryonicBrain.svg" xsd:anyURI property_value: RO:0002175 NCBITaxon:7762 {source="PMID:8932866"} property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "hindbrain" xsd:string [Term] id: UBERON:0002029 name: epithelium of gall bladder def: "The simple columnar epithelial lining of the gall bladder." [MP:0009492] subset: pheno_slim synonym: "biliary epithelium" RELATED [] synonym: "epithelial tissue of gall bladder" EXACT [OBOL:automatic] synonym: "epithelial tissue of gallbladder" EXACT [OBOL:automatic] synonym: "epithelium of gallbladder" EXACT [OBOL:automatic] synonym: "gall bladder epithelial tissue" EXACT [OBOL:automatic] synonym: "gall bladder epithelium" EXACT [] synonym: "gallbladder epithelial tissue" EXACT [OBOL:automatic] synonym: "gallbladder epithelium" EXACT [OBOL:automatic] xref: BTO:0001449 xref: CALOHA:TS-1304 xref: EMAPA:35370 xref: FMA:67711 xref: MA:0001632 xref: NCIT:C49227 xref: UMLS:C1180206 {source="ncithesaurus:Gallbladder_Epithelium"} is_a: UBERON:0000485 ! simple columnar epithelium is_a: UBERON:0034932 ! epithelium of biliary system intersection_of: UBERON:0000483 ! epithelium intersection_of: BFO:0000050 UBERON:0002110 ! part of gallbladder relationship: BFO:0000050 UBERON:0002110 ! part of gallbladder relationship: RO:0002433 UBERON:0002110 ! contributes to morphology of gallbladder property_value: skos:prefLabel "epithelium of gall bladder" xsd:string [Term] id: UBERON:0002030 name: nipple def: "Projection of skin containing the outlets for 15-20 lactiferous ducts arranged cylindrically around the tip." [FMA:67771, Wikipedia:Nipple] comment: Nipple being part_of mammary gland is due to a practical modelling in uberon that treats mammary gland as including adnexa. A GCI asserts that nipple is part of the breast in humans. For discussion of this, please refer to https://github.com/obophenotype/uberon/issues/1873. subset: pheno_slim subset: uberon_slim synonym: "papilla mammae" EXACT [MP:0009723] synonym: "papilla mammaria" RELATED OMO:0003011 [Wikipedia:Nipple] synonym: "papilla of breast" EXACT [] synonym: "papillary part of breast" NARROW [] synonym: "teat" NARROW [] synonym: "thele" EXACT [MP:0009723] synonym: "thelium" EXACT [MP:0009723] xref: BTO:0000821 xref: CALOHA:TS-2234 xref: EMAPA:36508 xref: FMA:67771 xref: GAID:35 xref: galen:Nipple xref: MA:0000796 xref: MESH:D009558 xref: NCIT:C12299 xref: SCTID:265780004 xref: UMLS:C0028109 {source="ncithesaurus:Nipple"} xref: Wikipedia:Nipple is_a: UBERON:0000475 ! organism subdivision is_a: UBERON:0004121 ! ectoderm-derived structure relationship: BFO:0000050 UBERON:0001911 ! part of mammary gland relationship: RO:0002162 NCBITaxon:32525 ! in taxon Theria relationship: RO:0002202 UBERON:0008425 {source="Stedmans"} ! develops from mammary ridge property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/5/59/Female_nipple_profile.jpg" xsd:anyURI property_value: seeAlso "https://github.com/obophenotype/uberon/issues/1873" xsd:string [Term] id: UBERON:0002031 name: epithelium of bronchus def: "An epithelium that is part of a bronchus [Automatically generated definition]." [OBOL:automatic] subset: efo_slim subset: pheno_slim synonym: "bronchi epithelial tissue" EXACT [OBOL:automatic] synonym: "bronchi epithelium" EXACT [OBOL:automatic] synonym: "bronchial epithelium" EXACT [] synonym: "bronchial trunk epithelial tissue" EXACT [OBOL:automatic] synonym: "bronchial trunk epithelium" EXACT [OBOL:automatic] synonym: "bronchus epithelial tissue" EXACT [OBOL:automatic] synonym: "bronchus epithelium" EXACT [] synonym: "epithelial tissue of bronchi" EXACT [OBOL:automatic] synonym: "epithelial tissue of bronchial trunk" EXACT [OBOL:automatic] synonym: "epithelial tissue of bronchus" EXACT [OBOL:automatic] synonym: "epithelium of bronchi" EXACT [OBOL:automatic] synonym: "epithelium of bronchial trunk" EXACT [OBOL:automatic] xref: BTO:0001845 xref: CALOHA:TS-1240 xref: EFO:0000307 xref: EMAPA:32691 xref: FMA:67782 xref: MA:0001839 xref: NCIT:C32231 xref: UMLS:C0599333 {source="ncithesaurus:Bronchial_Epithelium"} is_a: BFO:0000002 is_a: UBERON:0008397 ! tracheobronchial epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: BFO:0000050 UBERON:0002185 ! part of bronchus relationship: BFO:0000050 UBERON:0002185 ! part of bronchus relationship: BFO:0000051 CL:0002209 {source="FMA"} ! has part intermediate epitheliocyte relationship: RO:0002433 UBERON:0002185 ! contributes to morphology of bronchus property_value: skos:prefLabel "epithelium of bronchus" xsd:string [Term] id: UBERON:0002033 name: arrector muscle of hair def: "A tiny smooth muscle that connects the hair follicle with the dermis." [DOI:10.1016/j.cub.2008.12.005] subset: pheno_slim subset: uberon_slim synonym: "arectores pilorum" RELATED [BTO:0005132] synonym: "arrector pili" EXACT OMO:0003004 [FMA:67821, MA:0000778] synonym: "arrector pili muscle" EXACT OMO:0003004 [EMAPA:26779, MP:0010679] synonym: "arrector pili smooth muscle" EXACT OMO:0003004 [MA:0000778] synonym: "arrector pilli" EXACT OMO:0003004 [MP:0010679] synonym: "arrector pilli muscle" EXACT OMO:0003004 [MP:0010679] synonym: "arrector pilorum" EXACT [ISBN:0123813611] synonym: "arrector pilorum muscle of hair" EXACT [ISBN:0123813611] synonym: "erector pili" RELATED OMO:0003004 [BTO:0005132] synonym: "erectores pilorum" RELATED [BTO:0005132] synonym: "pilomotor muscle" RELATED [BTO:0005132] xref: BTO:0005132 xref: EMAPA:26775 xref: FMA:67821 xref: MA:0000778 xref: SCTID:319910005 xref: Wikipedia:Arrector_pili_muscle is_a: UBERON:0001135 {source="FMA"} ! smooth muscle tissue relationship: BFO:0000050 UBERON:0011932 {source="FMA"} ! part of pilosebaceous unit relationship: RO:0002371 UBERON:0002073 ! attached to hair follicle [Term] id: UBERON:0002034 name: suprachiasmatic nucleus def: "* An ovoid densely packed collection of small cells of the anterior hypothalamus lying close to the midline in a shallow impression of the optic chiasm. (MSH) * small group of nerve cell bodies in the supraoptic region of the hypothalamus, just above the optic chiasm; influences rhythmic aspects of hypothalamic functions in many vertebrate species. (CSP)." [BIRNLEX:1325] subset: efo_slim subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "nucleus suprachiasmaticus" RELATED OMO:0003011 [Wikipedia:Suprachiasmatic_nucleus] synonym: "nucleus suprachiasmaticus hypothalami" RELATED OMO:0003011 [NeuroNames:384] synonym: "SCh" BROAD OMO:0003000 [BIRNLEX:1325, NIFSTD:NeuroNames_abbrevSource] synonym: "SCN" BROAD OMO:0003000 [BIRNLEX:1325, NIFSTD:NeuroNames_abbrevSource] synonym: "SCN" RELATED [BTO:0001822] synonym: "suprachiasmatic nucleus (Spiegel-Zwieg)" RELATED [NeuroNames:384] synonym: "suprachiasmatic nucleus of hypothalamus" EXACT [] xref: BAMS:SCH xref: BAMS:SCh xref: BIRNLEX:1325 xref: BM:Die-Hy-SCN xref: BTO:0001822 xref: CALOHA:TS-0992 xref: DHBA:10480 xref: DMBA:15660 xref: EFO:0002475 xref: EMAPA:35841 xref: EV:0100228 xref: FMA:67883 xref: GAID:645 xref: HBA:12908 xref: MA:0000843 xref: MBA:286 xref: MESH:D013493 xref: NCIT:C74537 xref: neuronames:384 {source="BIRNLEX:1325"} xref: SCTID:369132004 xref: TAO:0000441 xref: UMLS:C0038866 {source="ncithesaurus:Suprachiasmatic_Nucleus", source="BIRNLEX:1325"} xref: UMLS:C1289559 {source="BIRNLEX:1325"} xref: VHOG:0000036 xref: Wikipedia:Suprachiasmatic_nucleus xref: XAO:0004072 xref: ZFA:0000441 is_a: UBERON:0006568 ! hypothalamic nucleus is_a: UBERON:0007251 ! preoptic nucleus relationship: BFO:0000050 UBERON:0002272 ! part of medial zone of hypothalamus relationship: RO:0002433 UBERON:0001898 ! contributes to morphology of hypothalamus property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/8/8c/HypothalamicNuclei.PNG" xsd:anyURI property_value: skos:prefLabel "suprachiasmatic nucleus" xsd:string [Term] id: UBERON:0002036 name: striated muscle tissue def: "Muscle tissue that contains fibers that are divided by transverse bands into striations." [CL:0000737, GOC:dph, GOC:mtg_muscle] subset: pheno_slim subset: uberon_slim synonym: "striated muscle" EXACT [] xref: AAO:0010762 xref: AEO:0000140 xref: CALOHA:TS-2047 xref: EHDAA2:0003140 xref: EMAPA:36390 xref: FMA:67905 xref: galen:StriatedMuscle xref: MA:0002438 xref: NCIT:C12436 xref: UMLS:C1331262 {source="ncithesaurus:Striated_Muscle_Tissue"} xref: WBbt:0005779 xref: Wikipedia:Striated_muscle is_a: UBERON:0002385 ! muscle tissue intersection_of: UBERON:0002385 ! muscle tissue intersection_of: RO:0002473 CL:0000737 ! composed primarily of striated muscle cell relationship: RO:0002473 CL:0000737 ! composed primarily of striated muscle cell property_value: skos:prefLabel "striated muscle tissue" xsd:string [Term] id: UBERON:0002037 name: cerebellum def: "Part of the metencephalon that lies in the posterior cranial fossa behind the brain stem. It is concerned with the coordination of movement[MESH]. A large dorsally projecting part of the brain concerned especially with the coordination of muscles and the maintenance of bodily equilibrium, situated between the brain stem and the back of the cerebrum , and formed in humans of two lateral lobes and a median lobe[BTO]. Brain structure derived from the anterior hindbrain, and perhaps including posterior midbrain. The cerebellum plays a role in somatic motor function, the control of muscle tone, and balance[ZFA]." [BTO:0000232, https://sourceforge.net/tracker/index.php?func=detail&aid=3291162&group_id=76834&atid=1205376, ISBN:3764351209, MESH:A08.186.211.132.810.428.200, ZFA:0000100] subset: efo_slim subset: human_reference_atlas subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "corpus cerebelli" RELATED OMO:0003011 [NeuroNames:643] synonym: "epencephalon-1" EXACT [FMA:67944] synonym: "infratentorial region" BROAD [Wikipedia:Tentorium_cerebelli] synonym: "parencephalon" RELATED OMO:0003011 [NeuroNames:643] xref: AAO:0010485 xref: BAMS:CB xref: BAMS:Cb xref: BIRNLEX:1489 xref: BM:CB xref: BTO:0000232 xref: CALOHA:TS-0125 xref: DHBA:10656 xref: EFO:0000327 xref: EHDAA2:0000232 xref: EMAPA:17787 xref: EV:0100293 xref: FMA:67944 xref: GAID:595 xref: HBA:4696 xref: MA:0000198 xref: MAT:0000110 xref: MBA:512 xref: MESH:D002531 xref: MIAA:0000110 xref: NCIT:C12445 xref: neuronames:643 {source="BIRNLEX:1489"} xref: SCTID:180924008 xref: TAO:0000100 xref: UMLS:C0007765 {source="BIRNLEX:1489", source="ncithesaurus:Cerebellum"} xref: UMLS:C1268981 {source="BIRNLEX:1489"} xref: VHOG:0000024 xref: Wikipedia:Cerebellum xref: XAO:0003098 xref: ZFA:0000100 is_a: UBERON:0002616 ! regional part of brain relationship: BFO:0000050 UBERON:0001895 {source="FMA", source="MA"} ! part of metencephalon relationship: RO:0002202 UBERON:0006215 {evidence="definitional"} ! develops from rhombic lip relationship: RO:0002433 UBERON:0001895 ! contributes to morphology of metencephalon property_value: foaf:depiction "https://upload.wikimedia.org/wikipedia/commons/a/a7/Cerebellum_NIH.png" xsd:anyURI property_value: RO:0002161 NCBITaxon:117565 {source="ISBN:0471888893"} property_value: RO:0002175 NCBITaxon:117569 {source="ISBN:0471888893"} property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "cerebellum" xsd:string [Term] id: UBERON:0002038 name: substantia nigra def: "Predominantly gray matter midbrain structure lying dorsal to the crus cerebri and ventral to the midbrain tegmentum. It is divided into a dorsal, cellularly compact region known as the pars compacta and a more ventrally located, containing more loosely packed cells, the pars reticulata. The most lateral region of the reticulata is identified as the pars lateralis (MM)." [BIRNLEX:789] subset: efo_slim subset: human_reference_atlas subset: pheno_slim subset: uberon_slim synonym: "nucleus of basis pedunculi" EXACT [] synonym: "nucleus pigmentosus subthalamo-peduncularis" RELATED OMO:0003011 [NeuroNames:536] synonym: "SN" BROAD OMO:0003000 [BIRNLEX:789, NIFSTD:NeuroNames_abbrevSource] synonym: "Soemmering's substance" EXACT [] synonym: "substancia nigra" RELATED [Wikipedia:Substantia_nigra] synonym: "substantia nigra (Soemmerringi)" RELATED OMO:0003011 [NeuroNames:536] xref: BAMS:SN xref: BIRNLEX:789 xref: BTO:0000143 xref: CALOHA:TS-0990 xref: DHBA:12251 xref: EFO:0000922 xref: EHDAA2:0004711 xref: EMAPA:35835 xref: EV:0100247 xref: FMA:67947 xref: GAID:581 xref: HBA:9072 xref: MA:0000210 xref: MAT:0000504 xref: MESH:D013378 xref: NCIT:C12453 xref: neuronames:536 {source="BIRNLEX:789"} xref: SCTID:279286002 xref: UMLS:C0038590 {source="BIRNLEX:789", source="ncithesaurus:Substantia_Nigra"} xref: UMLS:C1269578 {source="BIRNLEX:789"} xref: VHOG:0001573 xref: Wikipedia:Substantia_nigra is_a: UBERON:0009661 ! midbrain nucleus is_a: UBERON:0015212 ! lateral structure relationship: BFO:0000050 UBERON:0002420 {source="NIF"} ! part of basal ganglion relationship: BSPO:0000126 UBERON:0001891 {source="FMA-abduced-lr"} ! midbrain relationship: RO:0002433 UBERON:0001891 ! contributes to morphology of midbrain relationship: RO:0002433 UBERON:0010011 ! contributes to morphology of collection of basal ganglia property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/5/5f/Midbraincrosssection.png" xsd:anyURI property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/brain-female/v1.4/assets/3d-allen-f-brain.glb" xsd:anyURI property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/brain-male/v1.4/assets/3d-allen-m-brain.glb" xsd:anyURI property_value: IAO:0000116 "TODO - In BTO and NIF, part of basal ganglion which is part of telencephalon - but this is inconsistent with being part of midbrain, if these are spatially disjoint, as in ABA" xsd:string property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "substantia nigra" xsd:string [Term] id: UBERON:0002040 name: bronchial artery def: "A systemic artery that supplies the lung with with oxygenated blood." [UBERON:cjm, Wikipedia:Bronchial_artery] comment: Although there is much variation, there are usually two bronchial arteries that run to the left lung, and one to the right lung. subset: human_reference_atlas subset: uberon_slim synonym: "arteriae bronchiales" RELATED OMO:0003011 [Wikipedia:Bronchial_artery] synonym: "bronchial arterial tree" EXACT [] synonym: "rami bronchiales partis thoracicae aortae" RELATED OMO:0003011 [Wikipedia:Bronchial_artery] xref: EMAPA:18608 xref: FMA:68109 xref: GAID:477 xref: MA:0001923 xref: MESH:D001981 xref: NCIT:C32230 xref: SCTID:244247009 xref: UMLS:C0006257 {source="ncithesaurus:Bronchial_Artery"} xref: Wikipedia:Bronchial_artery is_a: UBERON:0004573 ! systemic artery intersection_of: UBERON:0004573 ! systemic artery intersection_of: BFO:0000050 UBERON:0004571 ! part of systemic arterial system intersection_of: RO:0020101 UBERON:0002048 ! vessel supplies blood to lung relationship: BFO:0000051 UBERON:0004848 ! has part respiratory system arterial endothelium relationship: BFO:0000051 UBERON:0012416 ! has part respiratory system arterial smooth muscle relationship: RO:0020101 UBERON:0002048 ! vessel supplies blood to lung property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/a/a7/Gray1032.png" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "bronchial artery" xsd:string [Term] id: UBERON:0002042 name: lymphatic vessel endothelium def: "An endothelium that is part of a lymphatic vessel [Automatically generated definition]." [OBOL:automatic] subset: human_reference_atlas subset: pheno_slim subset: vertebrate_core synonym: "endothelium of lymph vessel" EXACT [OBOL:automatic] synonym: "endothelium of lymphatic vessel" EXACT [FMA:68444] synonym: "lymph vessel endothelium" EXACT [OBOL:automatic] synonym: "lymphatic endothelium" EXACT [BTO:0004303] synonym: "lymphatic vessel endothelium" EXACT [] xref: BTO:0004303 xref: CALOHA:TS-2156 xref: EMAPA:35533 xref: FMA:68444 xref: MA:0000750 xref: MESH:D004729 xref: NCIT:C49258 xref: TAO:0005258 xref: UMLS:C1180786 {source="ncithesaurus:Lymphatic_Vessel_Endothelium"} xref: ZFA:0005258 is_a: UBERON:0004852 ! cardiovascular system endothelium intersection_of: UBERON:0001986 ! endothelium intersection_of: BFO:0000050 UBERON:0001473 ! part of lymphatic vessel relationship: BFO:0000050 UBERON:0001473 ! part of lymphatic vessel relationship: BFO:0000051 CL:0002138 {source="FMA"} ! has part endothelial cell of lymphatic vessel relationship: RO:0002433 UBERON:0001473 ! contributes to morphology of lymphatic vessel property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0002046 name: thyroid gland def: "A two-lobed endocrine gland found in all vertebrates, located in front of and on either side of the trachea in humans, and producing various hormones, such as triiodothyronine and calcitonin[BTO]." [BTO:0001379, Wikipedia:Thyroid] subset: efo_slim subset: organ_slim subset: pheno_slim subset: uberon_slim synonym: "glandula thyroidea" RELATED OMO:0003011 [Wikipedia:Thyroid] synonym: "thyroid" EXACT [] xref: AAO:0010544 xref: BTO:0001379 xref: CALOHA:TS-1047 xref: EFO:0000861 xref: EHDAA2:0002028 xref: EHDAA:2148 xref: EHDAA:2975 xref: EMAPA:17068 xref: EV:0100133 xref: FMA:9603 xref: GAID:465 xref: galen:ThyroidGland xref: MA:0000129 xref: MAT:0000081 xref: MESH:D013961 xref: MIAA:0000081 xref: NCIT:C12400 xref: SCTID:181117000 xref: UMLS:C0040132 {source="ncithesaurus:Thyroid_Gland"} xref: VHOG:0000418 xref: Wikipedia:Thyroid xref: XAO:0000162 is_a: UBERON:0002368 ! endocrine gland is_a: UBERON:0004119 ! endoderm-derived structure is_a: UBERON:0010314 ! structure with developmental contribution from neural crest relationship: BFO:0000067 GO:0006590 ! contains process thyroid hormone generation relationship: RO:0002215 GO:0036161 {source="Wikipedia"} ! capable of calcitonin secretion relationship: RO:0002216 GO:0055074 {source="Wikipedia"} ! capable of part of calcium ion homeostasis relationship: RO:0002494 UBERON:0007689 ! transformation of thyroid diverticulum property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/a/a3/Illu_thyroid_parathyroid.jpg" xsd:anyURI property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/c/c6/Illu_endocrine_system.jpg" xsd:anyURI [Term] id: UBERON:0002047 name: pontine raphe nucleus def: "The pontine raphe nucleus is one of the raphe nuclei. It is located in the pontine tegmentum. [WP,unvetted]." [Wikipedia:Pontine_raphe_nucleus] subset: pheno_slim subset: uberon_slim synonym: "nucleus raphe pontis" RELATED OMO:0003011 [NeuroNames:589] synonym: "nucleus raphes pontis" RELATED OMO:0003011 [Wikipedia:Pontine_raphe_nucleus] synonym: "raphe (mediana pontina)" RELATED OMO:0003011 [NeuroNames:589] synonym: "raphe of pons" EXACT [] synonym: "raphe pontis" EXACT OMO:0003011 [FMA:68875, FMA:TA] synonym: "raphe pontis nucleus" RELATED [] xref: BAMS:PnR xref: BAMS:RA-PONS xref: BAMS:RPn xref: BIRNLEX:1110 xref: DHBA:12475 xref: FMA:68875 xref: HBA:9159 xref: MA:0001022 xref: MBA:238 xref: neuronames:589 {source="BIRNLEX:1110"} xref: UMLS:C0175423 {source="BIRNLEX:1110"} xref: Wikipedia:Pontine_raphe_nucleus is_a: UBERON:0006331 ! brainstem nucleus is_a: UBERON:0009662 ! hindbrain nucleus relationship: BFO:0000050 UBERON:0003023 ! part of pontine tegmentum relationship: BFO:0000050 UBERON:0004684 {source="Wikipedia"} ! part of raphe nuclei property_value: skos:prefLabel "pontine raphe nucleus" xsd:string [Term] id: UBERON:0002048 name: lung def: "Respiration organ that develops as an outpocketing of the esophagus." [http://orcid.org/0000-0002-6601-2165] comment: Snakes and limbless lizards typically possess only the right lung as a major respiratory organ; the left lung is greatly reduced, or even absent. Amphisbaenians, however, have the opposite arrangement, with a major left lung, and a reduced or absent right lung [WP] subset: efo_slim subset: human_reference_atlas subset: major_organ subset: organ_slim subset: pheno_slim subset: uberon_slim synonym: "pulmo" EXACT OMO:0003011 [] xref: AAO:0000275 xref: AAO:0010567 xref: BTO:0000763 xref: CALOHA:TS-0568 xref: EFO:0000934 xref: EHDAA2:0001042 xref: EHDAA:1554 xref: EHDAA:2205 xref: EMAPA:16728 xref: EV:0100042 xref: FMA:7195 xref: GAID:345 xref: galen:Lung xref: MA:0000415 xref: MAT:0000135 xref: MESH:D008168 xref: MIAA:0000135 xref: NCIT:C12468 xref: SCTID:181216001 xref: UMLS:C0024109 {source="ncithesaurus:Lung"} xref: Wikipedia:Lung xref: XAO:0000119 is_a: BFO:0000002 is_a: UBERON:0000171 ! respiration organ is_a: UBERON:0005178 ! thoracic cavity element is_a: UBERON:0015212 ! lateral structure relationship: BFO:0000051 UBERON:0002185 ! has part bronchus relationship: BSPO:0000126 UBERON:0000170 ! pair of lungs relationship: RO:0002202 UBERON:0000118 ! develops from lung bud relationship: RO:0002433 UBERON:0001004 ! contributes to morphology of respiratory system property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/lung-female/v1.4/assets/3d-vh-f-lung.glb" xsd:anyURI property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/lung-male/v1.4/assets/3d-vh-m-lung.glb" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 property_value: seeAlso "https://github.com/obophenotype/uberon/issues/701" xsd:anyURI property_value: skos:prefLabel "lung" xsd:string [Term] id: UBERON:0002049 name: vasculature def: "An interconnected tubular multi-tissue structure contains fluid that is actively transported around the organism[ZFA]. Examples: vasculature of lung, vasculature of face." [ZFA:0005249] subset: human_reference_atlas subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "vascular network" EXACT [FMA:69050] xref: BTO:0003718 xref: FMA:69050 xref: TAO:0005249 xref: ZFA:0005249 is_a: BFO:0000004 is_a: UBERON:0000477 {source="FMA"} ! anatomical cluster relationship: BFO:0000050 UBERON:0007798 ! part of vascular system relationship: BFO:0000051 UBERON:0000179 ! has part haemolymphatic fluid relationship: RO:0002473 UBERON:0000055 ! composed primarily of vessel property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/2/29/Circulatory_System_en.svg" xsd:anyURI property_value: IAO:0000116 "see also: vascular system. Consider merging?" xsd:string property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "vasculature" xsd:string [Term] id: UBERON:0002050 name: embryonic structure def: "Anatomical structure that is part of an embryo." [BTO:0000174, ZFIN:curator] subset: efo_slim subset: inconsistent_with_fma subset: vertebrate_core synonym: "developing embryonic structure" EXACT [FBbt:00004208] synonym: "developing structure" RELATED [] synonym: "embryonale Struktur" RELATED [BTO:0000174] synonym: "embryonic anatomical structure" EXACT [RETIRED_EHDAA2:0003169] synonym: "embryonic structures" RELATED OMO:0003004 [ZFA:0001105] xref: AAO:0000138 xref: BILA:0000034 xref: BTO:0000174 xref: CALOHA:TS-2110 xref: EFO:0000461 xref: FBbt:00004208 {sssom:mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"} xref: FMA:69067 xref: GAID:407 xref: MESH:D004628 xref: NCIT:C13229 xref: RETIRED_EHDAA2:0003169 xref: SCTID:667009 xref: TAO:0001105 xref: UMLS:C0013948 {source="ncithesaurus:Embryonic_Structure"} xref: VSAO:0000178 xref: XAO:0003042 xref: ZFA:0001105 is_a: UBERON:0005423 ! developing anatomical structure intersection_of: UBERON:0005423 ! developing anatomical structure intersection_of: BFO:0000050 UBERON:0000922 ! part of embryo relationship: BFO:0000050 UBERON:0000922 ! part of embryo property_value: skos:prefLabel "embryonic structure" xsd:string [Term] id: UBERON:0002051 name: epithelium of bronchiole def: "An epithelium that is part of a bronchiole [Automatically generated definition]." [OBOL:automatic] subset: human_reference_atlas subset: pheno_slim synonym: "bronchiolar epithelium" EXACT [BTO:0001866] synonym: "bronchiole epithelial tissue" EXACT [OBOL:automatic] synonym: "bronchiole epithelium" EXACT [] synonym: "epithelial tissue of bronchiole" EXACT [OBOL:automatic] xref: BTO:0001866 xref: CALOHA:TS-0570 xref: EMAPA:32693 xref: FMA:69077 xref: MA:0001772 xref: NCIT:C48942 xref: UMLS:C1181296 {source="ncithesaurus:Bronchiole_Epithelium"} is_a: UBERON:0000115 ! lung epithelium is_a: UBERON:0003350 ! epithelium of mucosa is_a: UBERON:0008397 ! tracheobronchial epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: BFO:0000050 UBERON:0002186 ! part of bronchiole relationship: BFO:0000050 UBERON:0005039 ! part of mucosa of bronchiole relationship: BFO:0000051 CL:0000158 ! has part club cell relationship: BFO:0000051 CL:0002145 {source="FMA"} ! has part multiciliated columnar cell of tracheobronchial tree relationship: BFO:0000051 CL:1000271 ! has part lung multiciliated epithelial cell relationship: RO:0002433 UBERON:0002186 ! contributes to morphology of bronchiole property_value: RO:0002175 NCBITaxon:9606 property_value: terms:contributor https://orcid.org/0000-0001-6677-8489 [Term] id: UBERON:0002052 name: adrenal gland capsule def: "The thick capsule of dense irregular connective tissue that surrounds each adrenal gland and contains scattered elastic fibers; the capsule contains a rich plexus of blood vessels (mainly small arteries) and numerous nerve fibers; some blood vessels and nerves enter the substance of the gland in the trabeculae that extend inward from the capsule and then leave the trabeculae to enter the cortex." [MP:0013565] subset: pheno_slim synonym: "adrenal capsule" RELATED [] synonym: "capsule of adrenal gland" EXACT [FMA:69087] xref: FMA:69087 xref: MA:0000117 xref: NCIT:C32050 xref: UMLS:C1181304 {source="ncithesaurus:Adrenal_Gland_Capsule"} is_a: UBERON:0003893 ! capsule intersection_of: UBERON:0003893 ! capsule intersection_of: RO:0002007 UBERON:0002369 ! bounding layer of adrenal gland relationship: RO:0002007 UBERON:0002369 ! bounding layer of adrenal gland relationship: RO:0002433 UBERON:0001235 ! contributes to morphology of adrenal cortex relationship: RO:0002473 UBERON:0011822 ! composed primarily of dense irregular connective tissue [Term] id: UBERON:0002053 name: zona glomerulosa of adrenal gland def: "The narrow subcapsular outer zone of the adrenal cortex where aldosterone is produced." [MESH:A06.407.071.140.960, MGI:llw2, MP:0008293] subset: pheno_slim subset: uberon_slim synonym: "adrenal gland zona glomerulosa" EXACT [MA:0001891] synonym: "glomerulosa" RELATED [BTO:0000048] synonym: "zona glomerulosa" EXACT [] synonym: "zona glomerulosa of suprarenal gland" EXACT [] xref: BTO:0000048 xref: CALOHA:TS-0017 xref: EMAPA:35115 xref: FMA:69225 xref: GAID:449 xref: MA:0001891 xref: MESH:D015384 xref: SCTID:21476003 xref: Wikipedia:Zona_glomerulosa is_a: BFO:0000002 is_a: UBERON:0009753 {source="MA"} ! adrenal gland cortex zone relationship: BFO:0000051 CL:1000427 {source="FMA"} ! has part adrenal cortex chromaffin cell relationship: RO:0002215 GO:0032342 ! capable of aldosterone biosynthetic process relationship: RO:0002433 UBERON:0001235 ! contributes to morphology of adrenal cortex property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/5/5c/Gray1185.png" xsd:anyURI [Term] id: UBERON:0002056 name: inferior suprarenal artery def: "Each renal artery gives off some small inferior suprarenal branches to the suprarenal gland, the ureter, and the surrounding cellular tissue and muscles. [WP,unvetted]." [Wikipedia:Inferior_suprarenal_artery] subset: human_reference_atlas subset: uberon_slim synonym: "arteria suprarenalis inferior" RELATED OMO:0003011 [Wikipedia:Inferior_suprarenal_artery] xref: EMAPA:37088 {source="MA:th"} xref: FMA:69264 xref: MA:0002056 xref: NCIT:C52737 xref: SCTID:303426004 xref: UMLS:C0226334 {source="ncithesaurus:Inferior_Suprarenal_Artery"} xref: Wikipedia:Inferior_suprarenal_artery is_a: UBERON:0005624 ! suprarenal artery intersection_of: UBERON:0005624 ! suprarenal artery intersection_of: RO:0002252 UBERON:0001184 ! connecting branch of renal artery relationship: RO:0002252 UBERON:0001184 ! connecting branch of renal artery property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/6/61/Gray1121.png" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0002057 name: phrenic artery def: "An artery that supplies the diaphragm." [https://orcid.org/0000-0002-6601-2165] subset: uberon_slim xref: EMAPA:37108 {source="MA:th"} xref: FMA:69330 xref: MA:0002019 xref: NCIT:C33320 xref: UMLS:C1181536 {source="ncithesaurus:Phrenic_Artery"} is_a: UBERON:0004573 ! systemic artery intersection_of: UBERON:0004573 ! systemic artery intersection_of: RO:0020101 UBERON:0001103 ! vessel supplies blood to diaphragm relationship: RO:0020101 UBERON:0001103 ! vessel supplies blood to diaphragm property_value: skos:prefLabel "phrenic artery" xsd:string [Term] id: UBERON:0002058 name: main ciliary ganglion def: "A parasympathetic ganglion located in the posterior orbit that contains preganglionic nerves and postganglionic neurons of the oculomotor nerve, connects to the Edinger-Westphal nucleus via the oculomotor nerve and the eye muscles via the short ciliary nerve." [UBERON:cjm, Wikipedia:Ciliary_ganglion] subset: efo_slim subset: human_reference_atlas subset: pheno_slim subset: uberon_slim synonym: "ciliary ganglion" EXACT [MA:0001136] synonym: "ganglion ciliare" RELATED OMO:0003011 [Wikipedia:Ciliary_ganglion] xref: BAMS:GcIII xref: EFO:0002559 xref: EHDAA2:0000251 xref: EHDAA:5623 xref: EMAPA:18222 xref: FMA:6964 xref: MA:0001136 xref: NLXANAT:100304 xref: SCTID:279281007 xref: VHOG:0000805 xref: Wikipedia:Ciliary_ganglion is_a: UBERON:0001714 ! cranial ganglion is_a: UBERON:0035783 ! ganglion of ciliary nerve intersection_of: UBERON:0001808 ! parasympathetic ganglion intersection_of: extends_fibers_into UBERON:0001643 ! oculomotor nerve intersection_of: extends_fibers_into UBERON:0022302 ! short ciliary nerve relationship: BFO:0000050 UBERON:0035639 {source="http://orcid.org/0000-0001-9114-8737", source="inferred"} ! part of ocular adnexa relationship: extends_fibers_into UBERON:0001643 ! oculomotor nerve property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/3/30/Augennerven.jpg" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0002059 name: submandibular ganglion def: "The ganglion associated with the lingual nerve that provides postsynaptic fibers to the submandibular and sublingual glands." [ISBN:0-683-40008-8, MP:0001035] subset: human_reference_atlas subset: pheno_slim subset: uberon_slim synonym: "Blandin`s ganglion" RELATED [BTO:0001318] synonym: "ganglion submandibulare" RELATED OMO:0003011 [BTO:0001318, Wikipedia:Submandibular_ganglion] synonym: "lingual ganglion" RELATED [https://sourceforge.net/tracker/index.php?func=detail&aid=2979467&group_id=76834&atid=1205376, MA:0002470] synonym: "mandibular ganglion" EXACT SENSU [UBERON:cjm] synonym: "maxillary ganglion" RELATED [MA:0002470] synonym: "submaxillary ganglion" RELATED [MA:0002470] xref: BTO:0001318 xref: EHDAA2:0001942 xref: EHDAA:6710 xref: EMAPA:36276 xref: FMA:6966 xref: MA:0002470 xref: NCIT:C52558 xref: SCTID:279282000 xref: UMLS:C0229063 {source="ncithesaurus:Submandibular_Ganglion"} xref: Wikipedia:Submandibular_ganglion is_a: UBERON:0001808 ! parasympathetic ganglion intersection_of: UBERON:0000045 ! ganglion intersection_of: extends_fibers_into UBERON:0001736 ! submandibular gland relationship: extends_fibers_into UBERON:0001736 ! submandibular gland relationship: extends_fibers_into UBERON:0003721 ! lingual nerve property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/8/83/Gray778.png" xsd:anyURI property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/en/thumb/8/83/Gray778.png/200px-Gray778.png" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0002060 name: femoral artery def: "The femoral artery is a large artery in the muscles of the thigh. It is a continuation of external iliac artery where it enters the femoral triangle at the mid inguinal point behind the inguinal ligament. It leaves femoral triangle through apex beneath the sartorius muscle. It enters the popliteal fossa by passing through the 5th osseo-aponeurotic(adductor hiatus) opening of adductor magnus where it becomes the Popliteal Artery. [WP,unvetted]." [Wikipedia:Femoral_artery] subset: uberon_slim synonym: "arteria femoralis" RELATED OMO:0003011 [Wikipedia:Femoral_artery] xref: AAO:0010222 xref: BTO:0001624 xref: CALOHA:TS-0321 xref: EMAPA:35342 xref: FMA:70248 xref: GAID:494 xref: galen:FemoralArtery xref: MA:0001951 xref: MESH:D005263 xref: NCIT:C12715 xref: SCTID:244332003 xref: UMLS:C0015801 {source="ncithesaurus:Femoral_Artery"} xref: Wikipedia:Femoral_artery is_a: UBERON:0001637 ! artery relationship: RO:0002252 UBERON:0001308 {source="FMA", source="WP"} ! connecting branch of external iliac artery property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/7/7d/Gray546.png" xsd:anyURI [Term] id: UBERON:0002061 name: truncus arteriosus def: "The truncus arteriosus and bulbus cordis are divided by the aorticopulmonary septum. The truncus arteriosus gives rise to the ascending aorta and the pulmonary trunk. The bulbus cordis gives rise to the smooth parts (outflow tract) of the left and right ventricles." [Wikipedia:Truncus_arteriosus_(embryology)] subset: uberon_slim xref: EHDAA2:0004143 xref: EMAPA:35887 xref: FMA:70301 xref: GAID:554 xref: MA:0000103 xref: MESH:D014338 xref: NCIT:C34317 xref: SCTID:308828009 xref: UMLS:C1519589 {source="ncithesaurus:Trancus_Arteriosus"} xref: Wikipedia:Truncus_arteriosus_(embryology) is_a: UBERON:0001637 {source="EHDAA2"} ! artery is_a: UBERON:0002050 {source="FMA"} ! embryonic structure is_a: UBERON:0003498 ! heart blood vessel relationship: BFO:0000050 UBERON:0004145 {source="MA"} ! part of outflow tract relationship: BFO:0000050 UBERON:0005498 {source="EHDAA2"} ! part of primitive heart tube relationship: RO:0002202 UBERON:0005432 {source="EHDAA2"} ! develops from aortic sac property_value: skos:prefLabel "truncus arteriosus" xsd:string [Term] id: UBERON:0002062 name: endocardial cushion def: "The endocardial cushion is a specialized region of mesenchymal cells that will give rise to the heart septa and valves[GO]. Swellings of tissue present between the endocardial and myocardial cell layers that will give rise to the interstitial cells of the cardiac valves[ZFA]." [GO:0003197, Wikipedia:Atrioventricular_cushions, ZFIN:curator] comment: GO graph seems to suggest this is an endothelium. WP: The endocardial cushions are thought to arise from a subset of endothelial cells that undergo epithelial to mesenchymal transformation, a process whereby these cells break cell-to-cell contacts and migrate into the cardiac jelly (towards to interior of the heart tube). Latest (2010-06-01) new def suggested for GO, added above. Note that EHDAA2 has a more detailed model which we may later adopt. JB: Patterning makes the cushions lay down connective tissue in three domains that force out the local endothelial lining and so the leaflets form subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "atrioventricular canal cushion" RELATED [FMA:70302] synonym: "atrioventricular cushion" EXACT [Wikipedia:Endocardial_cushion] synonym: "AV cushion" EXACT [] synonym: "cardiac cushion" EXACT [PMID:15797462] synonym: "endocardial cushion tissue" EXACT [EHDAA2:0000434] synonym: "endocardial cushions" RELATED OMO:0003004 [] xref: EHDAA2:0000434 xref: EHDAA2:0004028 xref: EHDAA:2586 xref: EMAPA:16696 xref: FMA:70302 xref: MA:0000078 xref: TAO:0001317 xref: VHOG:0000932 xref: Wikipedia:Atrioventricular_cushions xref: XAO:0004189 xref: ZFA:0001317 is_a: UBERON:0002050 ! embryonic structure is_a: UBERON:0005256 ! trunk mesenchyme is_a: UBERON:0009751 ! cardiac mesenchyme is_a: UBERON:0014387 ! mesenchyme derived from neural crest relationship: BFO:0000050 UBERON:0002165 {source="ZFA"} ! part of endocardium property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/c/c7/Gray465.png" xsd:anyURI property_value: skos:prefLabel "endocardial cushion" xsd:string [Term] id: UBERON:0002063 name: sinus venosus def: "The sinus venosus is a large cardiac chamber at the inflow tract that receives venous blood from systemic circulation. precedes the atrium on the venous side of the chordate heart." [PMID:20735616, Wikipedia:Sinus_venosus] subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "inflow tract" BROAD [ZFA:0000154] synonym: "sinus venarum" RELATED [Wikipedia:Sinus_venosus] synonym: "sinus venosus cordis" RELATED OMO:0003011 [Wikipedia:Sinus_venosus] synonym: "venarum" RELATED [Wikipedia:Sinus_venosus] synonym: "venarum sinus" RELATED [Wikipedia:Sinus_venosus] synonym: "venosus" RELATED [Wikipedia:Sinus_venosus] xref: AAO:0010505 xref: EHDAA2:0001839 xref: EHDAA:480 xref: EMAPA:16237 xref: FMA:70303 xref: NCIT:C34299 xref: NCIT:C34300 xref: TAO:0000154 xref: UMLS:C0225857 {source="ncithesaurus:Sinus_Venarum"} xref: UMLS:C0231084 {source="ncithesaurus:Sinus_Venosus"} xref: VHOG:0000177 xref: Wikipedia:Sinus_venosus xref: ZFA:0000154 is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0004151 ! cardiac chamber disjoint_from: UBERON:0006615 ! venous sinus relationship: BFO:0000050 UBERON:0002350 {source="VHOG"} ! part of conducting system of heart relationship: RO:0002495 UBERON:0007278 {source="Bgee:AN"} ! immediate transformation of presumptive sinus venosus property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/c/c7/Gray465.png" xsd:anyURI property_value: skos:prefLabel "sinus venosus" xsd:string [Term] id: UBERON:0002066 name: umbilical vein def: "The umbilical vein is a blood vessel present during fetal development that carries oxygenated blood from the placenta to the growing fetus. [WP,unvetted]." [https://github.com/obophenotype/uberon/issues/328, Wikipedia:Umbilical_vein] subset: efo_slim subset: human_reference_atlas subset: pheno_slim subset: uberon_slim synonym: "vena umbilicalis" RELATED OMO:0003011 [Wikipedia:Umbilical_vein] xref: BTO:0001509 xref: CALOHA:TS-1082 xref: EFO:0001940 xref: EHDAA:1034 xref: EHDAA:488 xref: EMAPA:16243 xref: EMAPA:16375 xref: EV:0100392 xref: FMA:70317 xref: GAID:542 xref: MA:0002249 xref: MESH:D014471 xref: NCIT:C33830 xref: RETIRED_EHDAA2:0002107 xref: SCTID:367567000 xref: UMLS:C0041637 {source="ncithesaurus:Umbilical_Vein"} xref: Wikipedia:Umbilical_vein is_a: UBERON:0001638 ! vein is_a: UBERON:0010260 ! umbilical blood vessel property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/e/ee/Gray502.png" xsd:anyURI property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/placenta-full-term-female/v1.1/assets/3d-vh-f-placenta-full-term.glb" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0002067 name: dermis def: "The dermis is a layer of skin between the epidermis (with which it makes up the skin) and subcutaneous tissues, and is composed of two layers, the papillary and reticular dermis[WP]." [Wikipedia:Dermis, ZFIN:curator] subset: efo_slim subset: human_reference_atlas subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "corium" RELATED OMO:0003011 [BTO:0000294, Wikipedia:Dermis] synonym: "cutis" RELATED [BTO:0000294] synonym: "vertebrate dermis" EXACT [] xref: AAO:0000128 xref: BTO:0000294 xref: CALOHA:TS-2076 xref: EFO:0000953 xref: EMAPA:17527 xref: EV:0100154 xref: FMA:70323 xref: GAID:1321 xref: MA:0000152 xref: MAT:0000153 xref: MESH:D020405 xref: MIAA:0000153 xref: NCIT:C12701 xref: SCTID:361696001 xref: TAO:0001119 xref: UMLS:C0011646 {source="ncithesaurus:Dermis"} xref: VHOG:0000108 xref: Wikipedia:Dermis xref: XAO:0000217 xref: ZFA:0001119 is_a: UBERON:0010314 ! structure with developmental contribution from neural crest is_a: UBERON:0013754 ! integumentary system layer relationship: BFO:0000050 UBERON:0002097 {source="FMA"} ! part of skin of body relationship: BFO:0000051 GO:0071953 ! has part elastic fiber relationship: BFO:0000051 UBERON:0011860 ! has part collection of collagen fibrils relationship: BSPO:0000107 UBERON:0001003 ! skin epidermis relationship: BSPO:0000108 UBERON:0002072 ! hypodermis relationship: RO:0002473 UBERON:0002384 ! composed primarily of connective tissue relationship: RO:0002495 UBERON:0010083 {evidence="definitional"} ! immediate transformation of future dermis property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/2/23/EpidermisPainted.svg" xsd:anyURI property_value: IAO:0000116 "Consider adding a layer-of-skin grouping class for all skin layers" xsd:string property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "dermis" xsd:string [Term] id: UBERON:0002069 name: stratum granulosum of epidermis def: "The layer of flattened cells containing basophilic granules of keratohyalin and lying just above the stratum spinosum (spiny layer) of the epidermis." [ISBN:0-683-40008-8, MP:0001239] subset: human_reference_atlas subset: pheno_slim synonym: "epidermis granular layer" RELATED [] synonym: "epidermis stratum granulosum" EXACT [] synonym: "granular layer of epidermis" EXACT [FMA:70344] synonym: "stratum granulosum" EXACT [BTO:0000361] xref: BTO:0000361 xref: EMAPA:32786 xref: FMA:70344 xref: MA:0000805 xref: NCIT:C33627 xref: SCTID:418563001 xref: UMLS:C0221923 {source="ncithesaurus:Stratum_Granulosum"} xref: Wikipedia:Stratum_granulosum is_a: BFO:0000002 is_a: UBERON:0013754 ! integumentary system layer intersection_of: UBERON:0013754 ! integumentary system layer intersection_of: RO:0002473 CL:0000712 ! composed primarily of stratum granulosum cell relationship: BFO:0000050 UBERON:0001003 ! part of skin epidermis relationship: BSPO:0015014 UBERON:0002026 ! stratum spinosum of epidermis relationship: RO:0002473 CL:0000712 ! composed primarily of stratum granulosum cell property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0002072 name: hypodermis def: "Lowermost layer of the integumentary system in vertebrates. Types of cells that are found in the hypodermis are fibroblasts, adipose cells, and macrophages. It is derived from the mesoderm, but unlike the dermis, it is not derived from the dermatome region of the mesoderm. The hypodermis is used mainly for fat storage[WP]." [Wikipedia:Hypodermis] subset: human_reference_atlas subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "hypoderm" EXACT [] synonym: "sub-tegumental tissue" RELATED [BTO:0004525] synonym: "subcutaneous tissue" RELATED [Wikipedia:Hypodermis] synonym: "subcutis" RELATED [] synonym: "subtegumental tissue" RELATED [BTO:0004525] synonym: "superficial fascia" RELATED INCONSISTENT [] synonym: "tela subcutanea" RELATED OMO:0003011 [Wikipedia:Hypodermis] synonym: "vertebrate hypodermis" EXACT [] xref: BTO:0001314 xref: CALOHA:TS-2366 xref: EMAPA:37505 {source="MA:th"} xref: FMA:70544 xref: MESH:D040521 {sssom:mapping_justification="https://w3id.org/semapv/vocab/LexicalMatching"} xref: NCIT:C33645 xref: TAO:0001136 xref: UMLS:C0278403 {source="ncithesaurus:Subcutis"} xref: Wikipedia:Hypodermis xref: ZFA:0001136 is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0013754 ! integumentary system layer relationship: BFO:0000050 UBERON:0002199 {source="ZFA"} ! part of integument relationship: BSPO:0000107 UBERON:0002067 ! dermis relationship: BSPO:0000108 UBERON:0001015 ! musculature relationship: RO:0002473 UBERON:0001013 ! composed primarily of adipose tissue relationship: RO:0002473 UBERON:0011825 {source="FMA-modified"} ! composed primarily of loose connective tissue property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/6/6d/Skin.svg" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "hypodermis" xsd:string [Term] id: UBERON:0002073 name: hair follicle def: "A tube-like opening in the epidermis where the hair shaft develops and into which the sebaceous glands open[GO]." [Wikipedia:Hair_follicle] comment: Development notes:Formation largely takes place during fetal and perinatal skin development. However, after skin wounding de novo hair follicle formation may also occur in adult mouse and rabbit skin[DOI:10.1016/j.cub.2008.12.005]. subset: efo_slim subset: human_reference_atlas subset: organ_slim subset: pheno_slim subset: uberon_slim synonym: "folliculus pili" RELATED OMO:0003011 [Wikipedia:Hair_follicle] xref: BTO:0000554 xref: CALOHA:TS-0432 xref: EFO:0002464 xref: EMAPA:18771 xref: EMAPA:29741 xref: EV:0100156 xref: FMA:70660 xref: GAID:934 xref: MA:0000154 xref: MESH:D018859 xref: NCIT:C13317 xref: SCTID:280830006 xref: UMLS:C0221971 {source="ncithesaurus:Hair_Follicle"} xref: VHOG:0001268 xref: Wikipedia:Hair_follicle is_a: BFO:0000002 is_a: UBERON:0036150 ! skin appendage follicle relationship: BFO:0000050 UBERON:0001003 {source="FMA"} ! part of skin epidermis relationship: BFO:0000050 UBERON:0011932 {source="DOI:10.1016/j.cub.2008.12.005"} ! part of pilosebaceous unit relationship: RO:0002131 UBERON:0001037 ! overlaps strand of hair relationship: RO:0002202 UBERON:0005086 ! develops from hair follicle placode property_value: foaf:depiction "https://upload.wikimedia.org/wikipedia/commons/4/4d/Hair_follicle-en.svg" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0002074 name: hair shaft def: "The main part of the hair which is composed of trichocytes and is divided into the cortex and medulla." [DOI:10.1016/j.cub.2008.12.005] subset: human_reference_atlas subset: pheno_slim synonym: "scapus pili" RELATED [BTO:0004672] synonym: "shaft of hair" EXACT [] xref: BTO:0004672 xref: EMAPA:36498 xref: FMA:70728 xref: MA:0000159 xref: NCIT:C33543 xref: SCTID:361359004 xref: UMLS:C0221961 {source="ncithesaurus:Shaft_of_the_Hair"} is_a: UBERON:0000021 ! cutaneous appendage relationship: BFO:0000050 UBERON:0001037 {source="DOI:10.1016/j.cub.2008.12.005"} ! part of strand of hair property_value: IAO:0000116 "TODO - add distinct subclasses for coat hair vs vibrissa hair" xsd:string property_value: IAO:0000116 "TODO - check definition of trichocyte in CL" xsd:string property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0002075 name: viscus def: "An organ that is located within the body cavity (or in its extension, in the scrotum); it consists of organ parts that are embryologically derived from endoderm, splanchnic mesoderm or intermediate mesoderm; together with other organs, the viscus constitutes the respiratory, gastrointestinal, urinary, reproductive and immune systems, or is the central organ of the cardiovascular system. Examples: heart, lung, esophagus, kidney, ovary, spleen." [BTO:0001491, https://github.com/obophenotype/mouse-anatomy-ontology/issues/14, Wikipedia:Viscus] subset: organ_slim subset: pheno_slim subset: uberon_slim subset: upper_level synonym: "splanchnic tissue" RELATED [BTO:0001491] synonym: "viscera" RELATED [] synonym: "visceral organ" EXACT [RETIRED_EHDAA2:0002201] synonym: "visceral organ system" EXACT [MA:0000019] synonym: "visceral tissue" RELATED [BTO:0001491] xref: AAO:0010386 xref: BTO:0001491 xref: EHDAA:512 xref: EMAPA:16245 xref: FMA:7085 xref: MA:0000019 xref: MESH:D014781 xref: NCIT:C28287 xref: RETIRED_EHDAA2:0002201 xref: SCTID:118760003 xref: UMLS:C0042779 {source="ncithesaurus:Viscera"} xref: Wikipedia:Viscus xref: XAO:0003034 is_a: UBERON:0005177 ! trunk region element intersection_of: UBERON:0000062 ! organ intersection_of: RO:0001025 UBERON:0002323 ! located in coelemic cavity lumen relationship: RO:0001025 UBERON:0002323 ! located in coelemic cavity lumen property_value: skos:prefLabel "viscus" xsd:string [Term] id: UBERON:0002076 name: cuticle of hair def: "Smooth and glossy outer protective cell layer of hair shaft." [MGI:llw2, MP:0003810] subset: human_reference_atlas subset: pheno_slim synonym: "hair cuticle" EXACT [] xref: EMAPA:35388 xref: FMA:70933 xref: MA:0000157 is_a: UBERON:0000119 ! cell layer intersection_of: UBERON:0000119 ! cell layer intersection_of: RO:0002007 UBERON:0002074 ! bounding layer of hair shaft relationship: RO:0002007 UBERON:0002074 ! bounding layer of hair shaft property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0002077 name: cortex of hair def: "A cortex that is part of a hair [Automatically generated definition]." [OBOL:automatic] subset: human_reference_atlas subset: pheno_slim synonym: "coat hair cortex" EXACT [OBOL:automatic] synonym: "coat/hair cortex" EXACT [OBOL:automatic] synonym: "cortex of coat hair" EXACT [OBOL:automatic] synonym: "cortex of coat/hair" EXACT [OBOL:automatic] synonym: "hair cortex" EXACT [] xref: EMAPA:35387 xref: FMA:70934 xref: MA:0000156 xref: SCTID:318832008 is_a: UBERON:0001851 ! cortex intersection_of: UBERON:0001851 ! cortex intersection_of: BFO:0000050 UBERON:0001037 ! part of strand of hair relationship: BFO:0000050 UBERON:0002074 ! part of hair shaft property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0002078 name: right cardiac atrium def: "A cardiac atrium that is in the right side of the heart. It receives deoxygenated blood. In mammals, this comes from the superior and inferior vena cava and the coronary sinus, and pumps it into the right ventricle through the tricuspid valve." [http://orcid.org/0000-0002-6601-2165, Wikipedia:Right_atrium] subset: human_reference_atlas subset: pheno_slim subset: uberon_slim synonym: "atrium dextrum" RELATED OMO:0003011 [Wikipedia:Right_atrium] synonym: "cardiac right atrium" EXACT [] synonym: "heart right atrium" EXACT [MA:0000075] synonym: "right atrium" EXACT [VHOG:0000328] synonym: "right atrium of heart" EXACT [] synonym: "right cardiac atrium" EXACT [] xref: AAO:0010248 xref: BTO:0001703 xref: EHDAA2:0000290 xref: EMAPA:17321 xref: FMA:7096 xref: galen:RightAtrium xref: MA:0000075 xref: NCIT:C12868 xref: SCTID:244383003 xref: UMLS:C0225844 {source="ncithesaurus:Right_Atrium"} xref: VHOG:0000328 xref: Wikipedia:Right_atrium xref: XAO:0003192 is_a: UBERON:0002081 ! cardiac atrium is_a: UBERON:0035554 ! right cardiac chamber intersection_of: UBERON:0002081 ! cardiac atrium intersection_of: BSPO:0000121 UBERON:0000948 ! heart relationship: RO:0002170 UBERON:0004537 ! connected to blood vasculature property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/2/20/Diagram_of_the_human_heart_%28cropped%29.svg" xsd:anyURI property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/heart-female/v1.3/assets/3d-vh-f-heart.glb" xsd:anyURI property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/heart-male/v1.3/assets/3d-vh-m-heart.glb" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "right cardiac atrium" xsd:string [Term] id: UBERON:0002079 name: left cardiac atrium def: "A cardiac atrium that is in the left side of the heart. It receives oxygenated blood from the pulmonary veins, In mammals this is pumped into the left ventricle, via the Mitral valve." [http://orcid.org/0000-0002-6601-2165, Wikipedia:Left_atrium] subset: human_reference_atlas subset: pheno_slim subset: uberon_slim synonym: "atrium sinistrum" EXACT OMO:0003011 [Wikipedia:Left_atrium] synonym: "cardiac left atrium" EXACT [] synonym: "heart left atrium" EXACT [MA:0000074] synonym: "left atrium" EXACT [VHOG:0000369] synonym: "left atrium of heart" EXACT [] synonym: "left cardiac atrium" EXACT [] xref: AAO:0010247 xref: BTO:0001702 xref: EHDAA2:0000275 xref: EMAPA:17315 xref: FMA:7097 xref: galen:LeftAtrium xref: MA:0000074 xref: NCIT:C12869 xref: SCTID:244387002 xref: UMLS:C0225860 {source="ncithesaurus:Left_Atrium"} xref: VHOG:0000369 xref: Wikipedia:Left_atrium xref: XAO:0003191 is_a: UBERON:0002081 ! cardiac atrium is_a: UBERON:0035553 ! left cardiac chamber intersection_of: UBERON:0002081 ! cardiac atrium intersection_of: BSPO:0000120 UBERON:0000948 ! heart relationship: RO:0002170 UBERON:0004537 ! connected to blood vasculature property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/2/20/Diagram_of_the_human_heart_%28cropped%29.svg" xsd:anyURI property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/heart-female/v1.3/assets/3d-vh-f-heart.glb" xsd:anyURI property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/heart-male/v1.3/assets/3d-vh-m-heart.glb" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "left cardiac atrium" xsd:string [Term] id: UBERON:0002080 name: heart right ventricle def: "A cardiac ventricle that is in the right side of the heart." [http://orcid.org/0000-0002-6601-2165] subset: human_reference_atlas subset: pheno_slim subset: uberon_slim synonym: "cardiac right ventricle" EXACT [] synonym: "right cardiac ventricle" RELATED [EMAPA:17340] synonym: "right ventricle" EXACT [FMA:7098] synonym: "right ventricle of heart" EXACT [] synonym: "ventriculus dexter" RELATED OMO:0003011 [Wikipedia:Right_ventricle] xref: BTO:0001630 xref: CALOHA:TS-0443 xref: EHDAA2:0000196 xref: EMAPA:17340 xref: FMA:7098 xref: galen:RightVentricle xref: MA:0000093 xref: NCIT:C12870 xref: SCTID:244384009 xref: UMLS:C0225883 {source="ncithesaurus:Right_Ventricle"} xref: VHOG:0000717 xref: Wikipedia:Right_ventricle is_a: UBERON:0002082 ! cardiac ventricle is_a: UBERON:0035554 ! right cardiac chamber intersection_of: UBERON:0002082 ! cardiac ventricle intersection_of: BSPO:0000121 UBERON:0000948 ! heart relationship: RO:0002170 UBERON:0004537 ! connected to blood vasculature relationship: RO:0002202 UBERON:0009889 {source="PMID:17276708"} ! develops from secondary heart field relationship: RO:0002254 UBERON:0004706 {source="cjm"} ! has developmental contribution from bulbus cordis property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/2/20/Diagram_of_the_human_heart_%28cropped%29.svg" xsd:anyURI property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/heart-female/v1.3/assets/3d-vh-f-heart.glb" xsd:anyURI property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/heart-male/v1.3/assets/3d-vh-m-heart.glb" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "heart right ventricle" xsd:string [Term] id: UBERON:0002081 name: cardiac atrium def: "Cardiac chamber in which blood enters the heart." [http://orcid.org/0000-0002-6601-2165, Wikipedia:Heart_atrium] subset: efo_slim subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "atria" EXACT OMO:0003004 [] synonym: "atrial tissue" RELATED [BTO:0000903] synonym: "atrium" EXACT [ZFA:0000471] synonym: "atrium of heart" EXACT [] synonym: "cardiac atria" EXACT OMO:0003004 [] synonym: "heart atrium" EXACT [] xref: AAO:0010246 xref: BTO:0000903 xref: CALOHA:TS-0437 xref: EFO:0000277 xref: EHDAA2:0000154 xref: EHDAA:1265 xref: EMAPA:16688 xref: EV:0100019 xref: FMA:7099 xref: GAID:555 xref: galen:Atrium xref: MA:0000073 xref: MAT:0000496 xref: MESH:D006325 xref: NCIT:C12728 xref: SCTID:261405004 xref: TAO:0000471 xref: UMLS:C0018792 {source="ncithesaurus:Cardiac_Atrium"} xref: VHOG:0000175 xref: Wikipedia:Heart_atrium xref: ZFA:0000471 is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0004151 ! cardiac chamber relationship: RO:0002433 UBERON:0000948 ! contributes to morphology of heart relationship: RO:0002495 UBERON:0010227 ! immediate transformation of future cardiac atrium property_value: skos:prefLabel "cardiac atrium" xsd:string [Term] id: UBERON:0002082 name: cardiac ventricle def: "Cardiac chamber through which blood leaves the heart." [http://orcid.org/0000-0002-6601-2165, Wikipedia:Ventricle_(heart)] subset: efo_slim subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "heart ventricle" EXACT [] synonym: "lower chamber of heart" EXACT [] synonym: "ventricle" BROAD [] synonym: "ventricle of heart" EXACT [] xref: AAO:0010249 xref: BTO:0000862 xref: CALOHA:TS-0444 xref: EFO:0000317 xref: EHDAA2:0004164 xref: EHDAA:1912 xref: EMAPA:17331 xref: EV:0100020 xref: FMA:7100 xref: GAID:568 xref: galen:Ventricle xref: MA:0000091 xref: MAT:0000497 xref: MESH:D006352 xref: NCIT:C12730 xref: SCTID:277699000 xref: TAO:0000009 xref: UMLS:C0018827 {source="ncithesaurus:Cardiac_Ventricle"} xref: VHOG:0000435 xref: Wikipedia:Ventricle_(heart) xref: XAO:0003193 xref: ZFA:0000009 is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0004151 ! cardiac chamber relationship: RO:0002433 UBERON:0000948 ! contributes to morphology of heart relationship: RO:0002495 UBERON:0006283 {source="Bgee:AN"} ! immediate transformation of future cardiac ventricle property_value: skos:prefLabel "cardiac ventricle" xsd:string [Term] id: UBERON:0002084 name: heart left ventricle def: "A cardiac ventricle that is in the left side of the heart." [http://orcid.org/0000-0002-6601-2165] subset: human_reference_atlas subset: pheno_slim subset: uberon_slim synonym: "cardiac left ventricle" EXACT [] synonym: "left cardiac ventricle" EXACT [] synonym: "left ventricle" EXACT [FMA:7101] synonym: "left ventricle of heart" EXACT [] synonym: "ventriculus sinister cordis" RELATED OMO:0003011 [Wikipedia:Left_ventricle] xref: BTO:0001629 xref: CALOHA:TS-0439 xref: EHDAA2:0002178 xref: EMAPA:17337 xref: FMA:7101 xref: galen:LeftVentricle xref: MA:0000092 xref: NCIT:C12871 xref: SCTID:244385005 xref: UMLS:C0225897 {source="ncithesaurus:Left_Ventricle"} xref: VHOG:0000718 xref: Wikipedia:Left_ventricle is_a: UBERON:0002082 ! cardiac ventricle is_a: UBERON:0035553 ! left cardiac chamber intersection_of: UBERON:0002082 ! cardiac ventricle intersection_of: BSPO:0000120 UBERON:0000948 ! heart relationship: RO:0002150 UBERON:0000947 ! continuous with aorta relationship: RO:0002170 UBERON:0004537 ! connected to blood vasculature property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/2/20/Diagram_of_the_human_heart_%28cropped%29.svg" xsd:anyURI property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/heart-female/v1.3/assets/3d-vh-f-heart.glb" xsd:anyURI property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/heart-male/v1.3/assets/3d-vh-m-heart.glb" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "heart left ventricle" xsd:string [Term] id: UBERON:0002085 name: interatrial septum def: "A cardiac septum that divides the left and right atria of the heart." [http://orcid.org/0000-0002-6601-2165] subset: pheno_slim subset: uberon_slim synonym: "atrial septum" EXACT [] synonym: "atrium septum" EXACT [] synonym: "interatrial septal wall" EXACT [] xref: EHDAA2:0000838 xref: EHDAA:1896 xref: EMAPA:17011 xref: FMA:7108 xref: galen:InteratrialSeptum xref: MA:0000084 xref: NCIT:C32818 xref: SCTID:362016003 xref: UMLS:C0225836 {source="ncithesaurus:Interatrial_Septum"} xref: VHOG:0000385 xref: Wikipedia:Interatrial_septum is_a: UBERON:0002099 ! cardiac septum intersection_of: UBERON:0002099 ! cardiac septum intersection_of: RO:0002220 UBERON:0002078 ! adjacent to right cardiac atrium intersection_of: RO:0002220 UBERON:0002079 ! adjacent to left cardiac atrium relationship: RO:0002220 UBERON:0002078 ! adjacent to right cardiac atrium relationship: RO:0002220 UBERON:0002079 ! adjacent to left cardiac atrium property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/6/6c/Gray493.png" xsd:anyURI property_value: skos:prefLabel "interatrial septum" xsd:string [Term] id: UBERON:0002089 name: thoracodorsal vein def: "Companion vein of the thoracodorsal artery, draining the apical part of the latissimus dorsi and merging with the circumflex scapular vein to form a subscapular vein." [http://www.medilexicon.com/medicaldictionary.php?t=97559] subset: human_reference_atlas xref: EMAPA:37198 {source="MA:th"} xref: FMA:71213 xref: MA:0002238 is_a: UBERON:0001638 ! vein intersection_of: UBERON:0001638 ! vein intersection_of: RO:0020102 UBERON:0001112 ! vessel drains blood from latissimus dorsi muscle relationship: RO:0002376 UBERON:0000985 {source="FMA/obol"} ! tributary of axillary vein relationship: RO:0020102 UBERON:0001112 ! vessel drains blood from latissimus dorsi muscle property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0002090 name: postcranial axial skeleton def: "The postcranial subdivision of skeleton structural components forming the long axis of the vertebrate body; in Danio, consisting of the notochord, vertebrae, ribs, supraneurals, intermuscular bones, and unpaired median fins; in human consists of the bones of the vertebral column, the thoracic cage and the pelvis[ZFA+FMA]." [https://sourceforge.net/tracker/?func=detail&aid=2983975&group_id=76834&atid=974957, https://sourceforge.net/tracker/?func=detail&atid=1205376&aid=2983977&group_id=76834, ZFA:0000317] comment: previous some AOs had used the term 'axial skeleton' to include the skull. This is being resolved (see tracker items above). Status: MA - fixed. subset: efo_slim subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "axial skeleton" BROAD [FMA:71221, https://github.com/obophenotype/uberon/wiki/The-axial-skeleton] synonym: "post-cranial axial skeleton" EXACT [] xref: AAO:0000034 xref: EFO:0000942 xref: EHDAA2:0000161 xref: EHDAA:5049 xref: EMAPA:37721 {source="MA:th"} xref: FMA:71221 xref: MA:0002986 xref: MAT:0000148 xref: MESH:D013131 {sssom:mapping_justification="https://w3id.org/semapv/vocab/LexicalMatching"} xref: MIAA:0000148 xref: TAO:0000317 xref: VHOG:0000317 xref: VSAO:0000093 xref: XAO:0003073 xref: ZFA:0000317 is_a: BFO:0000002 is_a: UBERON:0010912 ! subdivision of skeleton relationship: BFO:0000050 UBERON:0005944 ! part of axial skeleton plus cranial skeleton relationship: BFO:0000050 UBERON:0011138 ! part of postcranial axial skeletal system relationship: RO:0002202 UBERON:0003089 ! develops from sclerotome property_value: seeAlso "http://purl.obolibrary.org/obo/uberon/docs/The-axial-skeleton" xsd:anyURI property_value: skos:prefLabel "postcranial axial skeleton" xsd:string [Term] id: UBERON:0002091 name: appendicular skeleton def: "Subdivision of skeleton which which consists of all the skeletal elements in in the pectoral and pelvic appendage complexes[cjm]." [https://orcid.org/0000-0002-6601-2165, UBERONREF:0000003, Wikipedia:Appendicular_skeleton] subset: efo_slim subset: human_reference_atlas subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "appendicular skeleton" EXACT [] synonym: "entire appendicular skeleton" EXACT [https://github.com/obophenotype/uberon/issues/59] synonym: "paired fin skeleton" NARROW SENSU [] synonym: "skeleton appendiculare" RELATED OMO:0003011 [Wikipedia:Appendicular_skeleton] xref: AAO:0000747 xref: EFO:0000951 xref: EMAPA:32729 xref: FMA:71222 xref: MA:0000290 xref: MAT:0000278 xref: MIAA:0000278 xref: NCIT:C49477 xref: SCTID:322050006 xref: UMLS:C0222646 {source="ncithesaurus:Appendicular_Skeleton"} xref: VSAO:0000076 xref: Wikipedia:Appendicular_skeleton xref: XAO:0003166 is_a: UBERON:0010912 ! subdivision of skeleton relationship: BFO:0000050 UBERON:0011249 ! part of appendicular skeletal system relationship: RO:0002131 UBERON:0000026 ! overlaps appendage relationship: RO:0002433 UBERON:0001434 ! contributes to morphology of skeletal system property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/7/7c/Appendicular_skeleton_diagram.svg" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 property_value: seeAlso "https://github.com/obophenotype/uberon/wiki/Appendages-and-the-appendicular-skeleton" xsd:anyURI property_value: skos:prefLabel "appendicular skeleton" xsd:string [Term] id: UBERON:0002092 name: brain dura mater def: "The fibrous membrane forming the outer of the three coverings that surrounds the brain within the cranial cavity; consists of two layers including the periosteal layer and the meningeal layer." [MP:0009025] subset: pheno_slim synonym: "cranial dura mater" EXACT [FMA:71236] synonym: "dura mater cranialis" EXACT OMO:0003011 [FMA:71236, FMA:TA] synonym: "dura mater encephali" EXACT [] synonym: "dura mater of brain" EXACT [] xref: EMAPA:32668 xref: FMA:71236 xref: MA:0000815 xref: NCIT:C49332 xref: SCTID:309321003 xref: UMLS:C0459393 {source="ncithesaurus:Cerebral_Dura_Mater"} xref: VHOG:0000270 is_a: UBERON:0002363 ! dura mater is_a: UBERON:0003547 ! brain meninx intersection_of: UBERON:0002363 ! dura mater intersection_of: BFO:0000050 UBERON:0000955 ! part of brain property_value: skos:prefLabel "brain dura mater" xsd:string [Term] id: UBERON:0002093 name: spinal dura mater def: "A dura mater that is part of a spinal cord [Automatically generated definition]." [OBOL:automatic] subset: organ_slim subset: pheno_slim synonym: "dura mater of neuraxis of spinal cord" EXACT [OBOL:automatic] synonym: "dura mater of spinal cord" EXACT [] synonym: "spinal cord dura mater" EXACT [] synonym: "spinal cord dura mater of neuraxis" EXACT [OBOL:automatic] xref: EMAPA:17806 xref: FMA:71237 xref: MA:0001132 xref: NCIT:C49799 xref: SCTID:362302001 xref: UMLS:C0228124 {source="ncithesaurus:Spinal_Cord_Dura_Mater"} xref: VHOG:0000411 is_a: UBERON:0002363 ! dura mater is_a: UBERON:0003292 ! meninx of spinal cord intersection_of: UBERON:0002363 ! dura mater intersection_of: BFO:0000050 UBERON:0002240 ! part of spinal cord property_value: skos:prefLabel "spinal dura mater" xsd:string [Term] id: UBERON:0002094 name: interventricular septum def: "Cardiac septum which separates the right ventricle from the left ventricle.[FMA]." [FMA:7133] subset: efo_slim subset: human_reference_atlas subset: pheno_slim subset: uberon_slim synonym: "heart interventricular septum" EXACT [MA:0000085] synonym: "heart ventricular septum" EXACT [MA:0000085] synonym: "interventricular septum of heart" RELATED [BTO:0002483] synonym: "interventriculare cordis" RELATED [BTO:0002483] synonym: "intraventricular septum" RELATED [Wikipedia:Interventricular_septum] synonym: "s. interventriculare cordis" RELATED OMO:0003011 [Wikipedia:Interventricular_septum] synonym: "septum inferius" RELATED [Wikipedia:Interventricular_septum] synonym: "septum membranaceum" RELATED [Wikipedia:Interventricular_septum] synonym: "ventricle septum" RELATED [] synonym: "ventricular septum" RELATED [MA:0000085, Wikipedia:Interventricular_septum] xref: BTO:0002483 xref: EFO:0001956 xref: EHDAA:2603 xref: EMAPA:17333 xref: FMA:7133 xref: galen:InterventricularSeptum xref: MA:0000085 xref: NCIT:C32874 xref: SCTID:362019005 xref: UMLS:C0225870 {source="ncithesaurus:Interventricular_Septum"} xref: VHOG:0000386 xref: Wikipedia:Interventricular_septum is_a: UBERON:0002099 ! cardiac septum intersection_of: UBERON:0002099 ! cardiac septum intersection_of: RO:0002220 UBERON:0002080 ! adjacent to heart right ventricle intersection_of: RO:0002220 UBERON:0002084 ! adjacent to heart left ventricle relationship: RO:0002220 UBERON:0002080 ! adjacent to heart right ventricle relationship: RO:0002220 UBERON:0002084 ! adjacent to heart left ventricle property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/9/96/Gray498.png" xsd:anyURI property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/heart-female/v1.3/assets/3d-vh-f-heart.glb" xsd:anyURI property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/heart-male/v1.3/assets/3d-vh-m-heart.glb" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "interventricular septum" xsd:string [Term] id: UBERON:0002095 name: mesentery def: "Anatomical organ component composed of a double layer of serous membrane that suspends a viscus from the body wall or connects adjacent viscera and in doing so conveys blood vessels, lymphatics and nerves to and from the viscera. Examples: greater omentum, broad ligament of uterus, sigmoid mesocolon." [FMA:7144, https://github.com/obophenotype/uberon/issues/85, Wikipedia:Mesentery, Wikipedia:Mesentery#Mesentery_.28general.29] subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "generic mesentery" EXACT [Wikipedia:Mesentery] synonym: "mesentery (generic)" EXACT [Wikipedia:Mesentery] xref: AAO:0011061 xref: BTO:0001380 xref: EV:0100083 xref: FMA:7144 xref: GAID:21 xref: galen:Mesentery xref: MESH:D008643 xref: NCIT:C33103 xref: SCTID:362707009 xref: UMLS:C0025474 {source="ncithesaurus:Mesentery"} xref: Wikipedia:Mesentery#Mesentery_.28general.29 is_a: UBERON:0000042 ! serous membrane property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/1/19/Gray1038.png" xsd:anyURI property_value: terms:contributor https://orcid.org/0000-0002-6601-2165 [Term] id: UBERON:0002097 name: skin of body def: "The organ covering the body that consists of the dermis and epidermis." [UBERON:cjm] subset: efo_slim subset: human_reference_atlas subset: major_organ subset: pheno_slim subset: uberon_slim synonym: "entire integument" RELATED [] synonym: "entire skin" EXACT [] synonym: "integument" RELATED [] synonym: "integumental organ" RELATED [] synonym: "pelt" RELATED [] synonym: "skin" RELATED [] synonym: "skin organ" EXACT [] xref: BTO:0001253 xref: CALOHA:TS-0934 xref: EFO:0000962 xref: EHDAA2:0001844 xref: EMAPA:17525 xref: FMA:7163 xref: galen:Skin xref: MESH:D012867 xref: MFMO:0000099 xref: NCIT:C12470 xref: SCTID:181469002 xref: UMLS:C1123023 {source="ncithesaurus:Skin"} xref: Wikipedia:Skin xref: XAO:0000023 is_a: UBERON:0000062 ! organ is_a: UBERON:0010314 ! structure with developmental contribution from neural crest relationship: BFO:0000050 UBERON:0002199 ! part of integument relationship: RO:0002202 UBERON:0011272 {source="Wikipathways:WP2062"} ! develops from embryonic skin basal layer relationship: RO:0002473 UBERON:0000014 ! composed primarily of zone of skin property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/6/6d/Skin.svg" xsd:anyURI property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/skin-female/v1.5/assets/3d-vh-f-skin.glb" xsd:anyURI property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/skin-male/v1.4/assets/3d-vh-m-skin.glb" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "skin of body" xsd:string [Term] id: UBERON:0002099 name: cardiac septum def: "The thin membranous structure between parts of the heart, including the atria, ventricles, and outflow tract." [MESH:A07.541.459] subset: pheno_slim subset: uberon_slim synonym: "cardiac septa" EXACT OMO:0003004 [] synonym: "heart septa" EXACT OMO:0003004 [] synonym: "heart septum" EXACT [] synonym: "septum of heart" EXACT [] synonym: "spiral septa" RELATED OMO:0003004 [XAO:0004141] xref: EMAPA:35400 xref: FMA:7180 xref: GAID:562 xref: MA:0000083 xref: MESH:D006346 xref: NCIT:C49485 xref: SCTID:362014000 xref: UMLS:C0018819 {source="ncithesaurus:Heart_Septum"} is_a: UBERON:0003037 ! septum intersection_of: UBERON:0003037 ! septum intersection_of: BFO:0000050 UBERON:0000948 ! part of heart relationship: BFO:0000050 UBERON:0000948 ! part of heart relationship: RO:0002220 UBERON:0004151 ! adjacent to cardiac chamber relationship: RO:0002433 UBERON:0000948 ! contributes to morphology of heart property_value: skos:prefLabel "cardiac septum" xsd:string [Term] id: UBERON:0002100 name: trunk def: "Organism subdivision which is the part of the body posterior to the cervical region (or head, when cervical region not present) and anterior to the caudal region. Includes the sacrum when present." [TAO:0001115, UBERONREF:0000006, Wikipedia:Torso] subset: efo_slim subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "Rumpf" RELATED [BTO:0001493] synonym: "thoracolumbar region" EXACT [] synonym: "torso" EXACT [] synonym: "trunk region" EXACT [XAO:0000054] xref: AAO:0010339 xref: BILA:0000116 xref: BTO:0001493 xref: CALOHA:TS-1071 xref: EFO:0000966 xref: EMAPA:31857 xref: FMA:7181 xref: galen:Trunk xref: MA:0000004 xref: MAT:0000296 xref: MIAA:0000296 xref: NCIT:C33816 xref: SCTID:262225004 xref: TAO:0001115 xref: UMLS:C0460005 {source="ncithesaurus:Trunk"} xref: Wikipedia:Torso xref: XAO:0000054 xref: XAO:0003025 xref: ZFA:0001115 is_a: UBERON:0011676 ! subdivision of organism along main body axis disjoint_from: UBERON:0002464 ! nerve trunk relationship: BFO:0000050 UBERON:0013702 ! part of body proper property_value: skos:prefLabel "trunk" xsd:string [Term] id: UBERON:0002101 name: limb def: "A paired appendage that is evolved from a paired fin. The extent of this structure includes autopod, stylopod and zeugopod regions when present, but excludes the girdle and its parts." [UBERONREF:0000003] subset: efo_slim subset: pheno_slim subset: uberon_slim synonym: "extremities" RELATED OMO:0003004 [] synonym: "extremity" RELATED [] synonym: "flipper" NARROW SENSU [] synonym: "free limb" EXACT [FMA:24875] synonym: "limb sensu Vertebrata" EXACT [MAT:0000090] synonym: "pentadactyl limb" EXACT [] synonym: "tetrapod limb" EXACT [] xref: AAO:0010336 xref: AEO:0000172 xref: CALOHA:TS-0552 xref: EFO:0000876 xref: EHDAA2:0003172 xref: EHDAA:1697 xref: EHDAA:8273 xref: EMAPA:16405 xref: FMA:24875 xref: GAID:36 xref: galen:Extremity xref: MA:0000007 xref: MAT:0000090 xref: MESH:D005121 {sssom:mapping_justification="https://w3id.org/semapv/vocab/LexicalMatching"} xref: MIAA:0000090 xref: NCIT:C12429 xref: SCTID:243996003 xref: UMLS:C0015385 {source="ncithesaurus:Limb"} xref: VHOG:0000336 xref: VSAO:0000121 xref: Wikipedia:Limb xref: XAO:0003027 is_a: UBERON:0004708 ! paired limb/fin intersection_of: UBERON:0000475 ! organism subdivision intersection_of: RO:0002551 UBERON:0004381 ! has skeleton skeleton of limb relationship: RO:0002202 UBERON:0004347 ! develops from limb bud relationship: RO:0002492 UBERON:0000066 ! existence ends during fully formed stage relationship: RO:0002551 UBERON:0004381 ! has skeleton skeleton of limb [Term] id: UBERON:0002102 name: forelimb def: "A (free) limb that is connected to a pectoral girdle. The extent of this structure includes autopod, stylopod and zeugopod regions when present, but excludes the pectoral girdle and its parts." [UBERONREF:0000003] subset: efo_slim subset: pheno_slim subset: uberon_slim synonym: "anteriormost limb" EXACT [] synonym: "fore limb" EXACT [] synonym: "foreleg" RELATED [] synonym: "forelimb" EXACT [] synonym: "free part of upper limb" EXACT [FMA:24878] synonym: "free upper limb" EXACT [FMA:24878, UBERONREF:0000003] synonym: "membrum superius" EXACT OMO:0003011 [FMA:7183, FMA:TA] synonym: "pectoral flipper" NARROW SENSU [] synonym: "pectoral limb" EXACT [] synonym: "superior member" EXACT [] synonym: "upper extremity" EXACT [] synonym: "upper limb" EXACT [] xref: AAO:0000205 xref: BTO:0001729 xref: CALOHA:TS-2214 xref: EFO:0000882 xref: EHDAA2:0002133 xref: EHDAA:6208 xref: EMAPA:17412 xref: EV:0100014 xref: FMA:24878 xref: GAID:1215 xref: GAID:51 xref: galen:UpperExtremity xref: MA:0000025 xref: MAT:0000394 xref: MESH:D005552 xref: MIAA:0000394 xref: NCIT:C12671 xref: SCTID:182245002 xref: UMLS:C1140618 {source="ncithesaurus:Upper_Extremity"} xref: VHOG:0000338 xref: VSAO:0000148 xref: Wikipedia:Forelimb xref: XAO:0003030 is_a: UBERON:0002101 ! limb is_a: UBERON:0004710 ! pectoral appendage intersection_of: UBERON:0002101 ! limb intersection_of: BFO:0000050 UBERON:0010708 ! part of pectoral complex relationship: BFO:0000050 UBERON:0000153 ! part of anterior region of body relationship: BSPO:0000096 UBERON:0002103 ! hindlimb relationship: RO:0002202 UBERON:0005417 ! develops from forelimb bud relationship: RO:0002551 UBERON:0001440 ! has skeleton forelimb skeleton [Term] id: UBERON:0002103 name: hindlimb def: "A (free) limb that is connected to a pelvic girdle region. The extent of this structure includes autopod, stylopod and zeugopod regions when present, but excludes the pelvic girdle and its parts." [UBERONREF:0000003, Wikipedia:Hindlimb, Wikipedia:Lower_limb] subset: efo_slim subset: pheno_slim subset: uberon_slim synonym: "free lower limb" EXACT [FMA:24879, UBERONREF:0000003] synonym: "free part of lower limb" RELATED [FMA:24879] synonym: "hind limb" EXACT [] synonym: "hind-limb" EXACT [VSAO:0000150] synonym: "hindlimb" EXACT [] synonym: "inferior member" EXACT [] synonym: "lower extremity" RELATED [] synonym: "lower limb" EXACT [] synonym: "membrum inferius" EXACT OMO:0003011 [FMA:7184, FMA:TA] synonym: "membrum inferius" RELATED OMO:0003011 [Wikipedia:Lower_limb] synonym: "pelvic appendage" RELATED [] xref: AAO:0000219 xref: BTO:0002345 xref: CALOHA:TS-2215 xref: EFO:0000883 xref: EHDAA2:0001033 xref: EHDAA:6094 xref: EMAPA:17458 xref: EV:0100015 xref: FMA:24879 xref: GAID:1221 xref: GAID:38 xref: galen:LowerExtremity xref: MA:0000026 xref: MAT:0000395 xref: MESH:D006614 xref: MIAA:0000395 xref: NCIT:C12742 xref: NCIT:C77625 xref: SCTID:182281004 xref: UMLS:C0023216 {source="ncithesaurus:Lower_Extremity"} xref: UMLS:C1522391 {source="ncithesaurus:Hind_Limb"} xref: VHOG:0000337 xref: VSAO:0000150 xref: Wikipedia:Hindlimb xref: XAO:0003031 is_a: UBERON:0002101 ! limb is_a: UBERON:0004709 ! pelvic appendage intersection_of: UBERON:0002101 ! limb intersection_of: BFO:0000050 UBERON:0010709 ! part of pelvic complex relationship: BFO:0000050 UBERON:0000154 ! part of posterior region of body relationship: RO:0002202 UBERON:0005418 ! develops from hindlimb bud relationship: RO:0002551 UBERON:0001441 ! has skeleton hindlimb skeleton property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/d/dc/Gray1239.png" xsd:anyURI [Term] id: UBERON:0002104 name: visual system def: "The sensory system subserving the sense of vision." [NIFSTD:FMAID_7191] subset: human_reference_atlas subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "photosensory system" EXACT [BILA:0000140] synonym: "visual organ system" EXACT [] xref: AAO:0000632 xref: BILA:0000140 xref: EMAPA:36003 xref: FMA:7191 xref: http://uri.neuinfo.org/nif/nifstd/FMAID_7191 xref: MA:0002444 xref: NCIT:C12888 xref: SCTID:281831001 xref: TAO:0001127 xref: UMLS:C0587900 {source="ncithesaurus:Visual_System"} xref: Wikipedia:Visual_system xref: XAO:0003198 xref: ZFA:0001127 is_a: UBERON:0001032 ! sensory system relationship: RO:0002216 GO:0007601 ! capable of part of visual perception property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "visual system" xsd:string [Term] id: UBERON:0002105 name: vestibulo-auditory system def: "Sensory system responsible for the perception of spatial orientation and auditory stimuli." [ZFA:0001138] subset: functional_classification subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "auditory organ system" EXACT [] synonym: "auditory system" RELATED [] synonym: "auditory/vestibular system" RELATED [] synonym: "vestibuloauditory system" EXACT [] synonym: "vestibuloauditory system" RELATED [] xref: AAO:0000631 xref: EMAPA:37985 {source="MA:th"} xref: FMA:78500 xref: TAO:0001138 xref: XAO:0003195 xref: ZFA:0001138 is_a: UBERON:0001032 ! sensory system relationship: RO:0002216 GO:0007605 ! capable of part of sensory perception of sound property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/d/d2/Anatomy_of_the_Human_Ear.svg" xsd:anyURI property_value: skos:prefLabel "vestibulo-auditory system" xsd:string [Term] id: UBERON:0002106 name: spleen def: "The organ that functions to filter blood and to store red corpuscles and platelets." [ISBN:0-683-40008-8, MP:0000689] subset: efo_slim subset: human_reference_atlas subset: organ_slim subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "lien" RELATED OMO:0003011 [Wikipedia:Spleen] xref: AAO:0010395 xref: BTO:0001281 xref: CALOHA:TS-0956 xref: EFO:0000869 xref: EMAPA:18767 xref: EV:0100055 xref: FMA:7196 xref: GAID:1289 xref: galen:Spleen xref: MA:0000141 xref: MAT:0000085 xref: MESH:D013154 xref: MIAA:0000085 xref: NCIT:C12432 xref: SCTID:181279003 xref: TAO:0000436 xref: UMLS:C0037993 {source="ncithesaurus:Spleen"} xref: VHOG:0000120 xref: Wikipedia:Spleen xref: XAO:0000328 xref: ZFA:0000436 is_a: BFO:0000002 is_a: UBERON:0004177 ! hemopoietic organ is_a: UBERON:0005057 ! immune organ is_a: UBERON:0017672 ! abdominal viscera relationship: RO:0002162 NCBITaxon:7776 {source="multiple sources - true spleen appear in jawed vertebrates"} ! in taxon Gnathostomata relationship: RO:0002202 UBERON:0006293 ! develops from spleen primordium property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/spleen-female/v1.3/assets/3d-vh-f-spleen.glb" xsd:anyURI property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/spleen-male/v1.3/assets/3d-vh-m-spleen.glb" xsd:anyURI property_value: foaf:depiction "https://upload.wikimedia.org/wikipedia/commons/d/d6/Illu_spleen.jpg" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "spleen" xsd:string [Term] id: UBERON:0002107 name: liver def: "An exocrine gland which secretes bile and functions in metabolism of protein and carbohydrate and fat, synthesizes substances involved in the clotting of the blood, synthesizes vitamin A, detoxifies poisonous substances, stores glycogen, and breaks down worn-out erythrocytes[GO]." [BTO:0000759, Wikipedia:Liver] subset: efo_slim subset: human_reference_atlas subset: major_organ subset: organ_slim subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "iecur" RELATED OMO:0003011 [Wikipedia:Liver] synonym: "jecur" RELATED OMO:0003011 [Wikipedia:Liver] xref: AAO:0010111 xref: BTO:0000759 xref: CALOHA:TS-0564 xref: EFO:0000887 xref: EHDAA2:0000997 xref: EHDAA:2197 xref: EMAPA:16846 xref: EV:0100089 xref: FMA:7197 xref: GAID:288 xref: galen:Liver xref: MA:0000358 xref: MAT:0000097 xref: MESH:D008099 xref: MIAA:0000097 xref: NCIT:C12392 xref: SCTID:181268008 xref: TAO:0000123 xref: UMLS:C0023884 {source="ncithesaurus:Liver"} xref: VHOG:0000257 xref: Wikipedia:Liver xref: XAO:0000133 xref: ZFA:0000123 is_a: UBERON:0002365 {source="BTO", source="EHDAA2", source="GO-def"} ! exocrine gland is_a: UBERON:0004119 ! endoderm-derived structure is_a: UBERON:0005172 ! abdomen element is_a: UBERON:0006925 ! digestive system gland relationship: BFO:0000050 UBERON:0002423 {source="ZFA"} ! part of hepatobiliary system relationship: BFO:0000051 UBERON:0004647 ! has part liver lobule relationship: RO:0002131 UBERON:0002405 {source="ZFA-weakened"} ! overlaps immune system relationship: RO:0002202 UBERON:0004161 {source="EHDAA2"} ! develops from septum transversum relationship: RO:0002202 UBERON:0008836 {source="http://www.stembook.org/node/512"} ! develops from liver bud relationship: RO:0002433 UBERON:0002423 ! contributes to morphology of hepatobiliary system relationship: RO:0003000 UBERON:0001970 ! produces bile relationship: site_of GO:0002384 ! hepatic immune response relationship: site_of GO:0005978 ! glycogen biosynthetic process relationship: site_of GO:0005980 ! glycogen catabolic process property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/liver-female/v1.2/assets/3d-vh-f-liver.glb" xsd:anyURI property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/liver-male/v1.2/assets/3d-vh-m-liver.glb" xsd:anyURI property_value: foaf:depiction "https://upload.wikimedia.org/wikipedia/commons/6/64/Leber_Schaf.jpg" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "liver" xsd:string [Term] id: UBERON:0002108 name: small intestine def: "Subdivision of digestive tract that connects the stomach to the large intestine and is where much of the digestion and absorption of food takes place (with the exception of ruminants). The mammalian small intestine is long and coiled and can be differentiated histologically into: duodenum, jejunem, ileum[WP,cjm,Kardong]." [ISBN:0073040584, Wikipedia:Small_intestine] subset: efo_slim subset: human_reference_atlas subset: major_organ subset: organ_slim subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "anterior intestine" RELATED [] synonym: "intestinum tenue" RELATED OMO:0003011 [BTO:0000651, Wikipedia:Small_intestine] synonym: "mid intestine" RELATED [] synonym: "small bowel" EXACT [] synonym: "small intestine" EXACT [] xref: AAO:0010397 xref: BTO:0000651 xref: CALOHA:TS-0942 xref: EFO:0000841 xref: EMAPA:32834 xref: EV:0100072 xref: FMA:7200 xref: GAID:313 xref: galen:SmallIntestine xref: MA:0000337 xref: MAT:0000047 xref: MESH:D007421 xref: MIAA:0000047 xref: NCIT:C12386 xref: SCTID:181250005 xref: TAO:0001323 xref: UMLS:C0021852 {source="ncithesaurus:Small_Intestine"} xref: VHOG:0000055 xref: Wikipedia:Small_intestine xref: XAO:0000130 xref: ZFA:0001323 is_a: UBERON:0004921 ! subdivision of digestive tract is_a: UBERON:0013765 ! digestive system element relationship: BFO:0000050 UBERON:0000160 ! part of intestine relationship: RO:0002162 NCBITaxon:7742 ! in taxon Vertebrata relationship: RO:0002433 UBERON:0000160 ! contributes to morphology of intestine property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/8/82/Stomach_colon_rectum_diagram.svg" xsd:anyURI property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/small-intestine-female/v1.2/assets/3d-vh-f-small-intestine.glb" xsd:anyURI property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/small-intestine-male/v1.2/assets/3d-vh-m-small-intestine.glb" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "small intestine" xsd:string [Term] id: UBERON:0002109 name: pair of nares def: "Pair of nostrils." [Wikipedia:Nares] subset: uberon_slim synonym: "nares" RELATED [] synonym: "nares set" EXACT [] synonym: "nostrils" EXACT [] synonym: "pair of nostrils" EXACT [] synonym: "set of nares" RELATED [FMA:72005] xref: FMA:72005 xref: Wikipedia:Nares is_a: BFO:0000004 is_a: UBERON:0034925 ! anatomical collection intersection_of: UBERON:0034925 ! anatomical collection intersection_of: RO:0002351 UBERON:0000003 {cardinality="2"} ! has member naris relationship: BFO:0000050 UBERON:0000004 ! part of nose relationship: RO:0002351 UBERON:0000003 ! has member naris property_value: RO:0002161 NCBITaxon:7745 {source="http://webs.lander.edu/rsfox/invertebrates/ammocoetes.html"} [Term] id: UBERON:0002110 name: gallbladder def: "An organ that aids digestion and stores bile produced by the liver[WP]." [Wikipedia:Gallbladder] comment: Rats do not have a gallbladder, but produce bile. The bile flows directly from the liver through the (hepatic) bile duct into the small intestine (Hebel and Stromberg, 1988) subset: efo_slim subset: organ_slim subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "cholecyst" EXACT [WikipediaVersioned:Gallbladder&oldid=1092217922] synonym: "gall bladder" EXACT [] synonym: "vesica biliaris" RELATED OMO:0003011 [Wikipedia:Gallbladder] synonym: "vesica fellea" RELATED OMO:0003011 [Wikipedia:Gallbladder] xref: AAO:0010114 xref: BTO:0000493 xref: CALOHA:TS-0394 xref: EFO:0000853 xref: EHDAA2:0000699 xref: EHDAA:8062 xref: EMAPA:17202 xref: EV:0100090 xref: FMA:7202 xref: galen:Gallbladder xref: MA:0000356 xref: MAT:0000072 xref: MESH:D005704 xref: MIAA:0000072 xref: NCIT:C12377 xref: SCTID:181269000 xref: TAO:0000208 xref: UMLS:C0016976 {source="ncithesaurus:Gallbladder"} xref: VHOG:0000221 xref: Wikipedia:Gallbladder xref: XAO:0000135 xref: ZFA:0000208 is_a: UBERON:0004119 ! endoderm-derived structure is_a: UBERON:0013765 ! digestive system element is_a: UBERON:0017672 ! abdominal viscera is_a: UBERON:0018707 {source="BTO"} ! bladder organ relationship: BFO:0000050 UBERON:0002294 ! part of biliary system relationship: RO:0002202 UBERON:0004912 ! develops from biliary bud relationship: RO:0002202 UBERON:0006242 {evidence="definitional"} ! develops from gallbladder primordium relationship: RO:0002433 UBERON:0001173 ! contributes to morphology of biliary tree property_value: foaf:depiction "https://upload.wikimedia.org/wikipedia/commons/b/b1/GallbladderAnatomy-en.svg" xsd:anyURI property_value: foaf:depiction "https://upload.wikimedia.org/wikipedia/commons/f/f4/Abdomal_organs.svg" xsd:anyURI property_value: RO:0002161 NCBITaxon:10114 {source="ISBN:9780120749034"} property_value: RO:0002161 NCBITaxon:8801 {source="GOC:mr", source="ISBN:9781840761122"} property_value: RO:0002161 NCBITaxon:8930 {source="GOC:mr", source="ISBN:9781840761122"} property_value: skos:prefLabel "gallbladder" xsd:string [Term] id: UBERON:0002111 name: artery smooth muscle tissue def: "A portion of smooth muscle tissue that is part of an artery [Automatically generated definition]." [OBOL:automatic] synonym: "arterial smooth muscle" EXACT [BTO:0000087] synonym: "arterial smooth muscle cell" RELATED [BTO:0000087] synonym: "artery smooth muscle" EXACT [] synonym: "artery smooth muscle tissue" EXACT [] synonym: "smooth muscle of artery" EXACT [FMA:72024] xref: BTO:0000087 xref: CALOHA:TS-1198 xref: EMAPA:36285 xref: FMA:72024 xref: MA:0000708 xref: NCIT:C49195 xref: UMLS:C1706851 {source="ncithesaurus:Artery_Smooth_Muscle_Tissue"} is_a: UBERON:0004237 ! blood vessel smooth muscle is_a: UBERON:0004695 ! arterial system smooth muscle intersection_of: UBERON:0001135 ! smooth muscle tissue intersection_of: BFO:0000050 UBERON:0001637 ! part of artery relationship: BFO:0000050 UBERON:0001637 ! part of artery property_value: skos:prefLabel "artery smooth muscle tissue" xsd:string [Term] id: UBERON:0002112 name: smooth muscle of esophagus def: "A portion of smooth muscle tissue that is part of a esophagus [Automatically generated definition]." [OBOL:automatic] subset: pheno_slim synonym: "esophageal smooth muscle" EXACT [] synonym: "esophagus involuntary muscle" EXACT [OBOL:automatic] synonym: "esophagus non-striated muscle" EXACT [OBOL:automatic] synonym: "esophagus smooth muscle" EXACT [] synonym: "esophagus smooth muscle tissue" EXACT [OBOL:automatic] synonym: "gullet involuntary muscle" EXACT [OBOL:automatic] synonym: "gullet non-striated muscle" EXACT [OBOL:automatic] synonym: "gullet smooth muscle" EXACT [OBOL:automatic] synonym: "gullet smooth muscle tissue" EXACT [OBOL:automatic] synonym: "involuntary muscle of esophagus" EXACT [OBOL:automatic] synonym: "involuntary muscle of gullet" EXACT [OBOL:automatic] synonym: "involuntary muscle of oesophagus" EXACT [OBOL:automatic] synonym: "non-striated muscle of esophagus" EXACT [OBOL:automatic] synonym: "non-striated muscle of gullet" EXACT [OBOL:automatic] synonym: "non-striated muscle of oesophagus" EXACT [OBOL:automatic] synonym: "oesophagus involuntary muscle" EXACT [OBOL:automatic] synonym: "oesophagus non-striated muscle" EXACT [OBOL:automatic] synonym: "oesophagus smooth muscle" RELATED [] synonym: "oesophagus smooth muscle tissue" EXACT [OBOL:automatic] synonym: "smooth muscle of gullet" EXACT [OBOL:automatic] synonym: "smooth muscle of oesophagus" EXACT [OBOL:automatic] synonym: "smooth muscle tissue of esophagus" EXACT [OBOL:automatic] synonym: "smooth muscle tissue of gullet" EXACT [OBOL:automatic] synonym: "smooth muscle tissue of oesophagus" EXACT [OBOL:automatic] xref: EMAPA:35323 xref: FMA:72025 xref: MA:0001573 is_a: UBERON:0001135 ! smooth muscle tissue intersection_of: UBERON:0001135 ! smooth muscle tissue intersection_of: BFO:0000050 UBERON:0001043 ! part of esophagus relationship: BFO:0000050 UBERON:0003832 ! part of esophagus muscle relationship: RO:0002433 UBERON:0001043 ! contributes to morphology of esophagus property_value: skos:prefLabel "smooth muscle of esophagus" xsd:string [Term] id: UBERON:0002113 name: kidney def: "A paired organ of the urinary tract that produces urine and maintains bodily fluid homeostasis, blood pressure, pH levels, red blood cell production and skeleton mineralization." [http://anatomy.uams.edu/anatomyhtml/kidney.html, https://www.kidney.org/kidneydisease/top-5-jobs-kidneys-do, PMID:25140012, PMID:35003210, Wikipedia:Kidney] subset: efo_slim subset: human_reference_atlas subset: major_organ subset: organ_slim subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "reniculate kidney" NARROW SENSU [Wikipedia:Reniculate_kidney] xref: AAO:0000250 xref: BTO:0000671 xref: CALOHA:TS-0510 xref: GAID:423 xref: galen:Kidney xref: MAT:0000119 xref: MESH:D007668 xref: MIAA:0000119 xref: UMLS:C0022646 {source="ncithesaurus:Kidney"} xref: Wikipedia:Kidney xref: XAO:0003267 is_a: BFO:0000002 is_a: UBERON:0000489 ! cavitated compound organ is_a: UBERON:0005172 ! abdomen element is_a: UBERON:0015212 ! lateral structure relationship: BFO:0000050 UBERON:0011143 {source="FMA"} ! part of upper urinary tract relationship: BSPO:0000126 UBERON:0000468 ! multicellular organism relationship: RO:0002202 UBERON:0003918 {evidence="definitional"} ! develops from kidney mesenchyme relationship: RO:0002202 UBERON:0005095 ! develops from kidney rudiment relationship: RO:0002433 UBERON:0001008 ! contributes to morphology of renal system property_value: RO:0002175 NCBITaxon:9606 property_value: terms:contributor https://orcid.org/0000-0001-7655-4833 property_value: terms:contributor https://orcid.org/0000-0003-2804-127X [Term] id: UBERON:0002114 name: duodenum def: "The first part of the small intestine. At the junction of the stomach and the duodenum the alimentary canal is inflected. The duodenum first goes anteriorly for a short distance, turns dorsally, and eventually caudally, thus it is a U-shaped structure with two horizontal sections (a ventral and a dorsal one)." [ISBN:0815318960, Wikipedia:Duodenum] subset: efo_slim subset: human_reference_atlas subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "proximal intestine" RELATED [BTO:0000365] synonym: "upper intestine" RELATED [BTO:0000365] xref: AAO:0010402 xref: BTO:0000365 xref: CALOHA:TS-0214 xref: EFO:0000851 xref: EMAPA:18852 xref: EV:0100073 xref: FMA:7206 xref: GAID:284 xref: galen:Duodenum xref: MA:0000338 xref: MAT:0000044 xref: MESH:D004386 xref: MIAA:0000044 xref: NCIT:C12263 xref: SCTID:181247007 xref: UMLS:C0013303 {source="ncithesaurus:Duodenum"} xref: VHOG:0000052 xref: Wikipedia:Duodenum xref: XAO:0000236 is_a: UBERON:0004921 ! subdivision of digestive tract relationship: BSPO:0001106 UBERON:0002108 ! small intestine relationship: RO:0002150 UBERON:0001166 ! continuous with pylorus relationship: RO:0002433 UBERON:0002108 ! contributes to morphology of small intestine property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/b/b3/Tractus_intestinalis_duodenum.svg" xsd:anyURI property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/small-intestine-female/v1.2/assets/3d-vh-f-small-intestine.glb" xsd:anyURI property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/small-intestine-male/v1.2/assets/3d-vh-m-small-intestine.glb" xsd:anyURI property_value: RO:0002161 NCBITaxon:7955 {source="ZFA:0000348"} property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "duodenum" xsd:string [Term] id: UBERON:0002115 name: jejunum def: "The portion of the small intestine that extends from the duodenum to the ileum." [MGI:monikat, MP:0004002] subset: efo_slim subset: human_reference_atlas subset: pheno_slim subset: uberon_slim synonym: "intestinum jejunum" RELATED [BTO:0000657] synonym: "mid-intestine" RELATED [Wikipedia:Jejunum] synonym: "middle intestine" RELATED [BTO:0000657] xref: BTO:0000657 xref: CALOHA:TS-0496 xref: EFO:0001333 xref: EMAPA:18666 xref: EV:0100074 xref: FMA:7207 xref: GAID:318 xref: galen:Jejunum xref: MA:0000340 xref: MAT:0000045 xref: MESH:D007583 xref: MIAA:0000045 xref: NCIT:C12388 xref: SCTID:181248002 xref: UMLS:C0022378 {source="ncithesaurus:Jejunum"} xref: VHOG:0000053 xref: Wikipedia:Jejunum is_a: BFO:0000002 is_a: UBERON:0004921 ! subdivision of digestive tract relationship: BFO:0000050 UBERON:0002108 ! part of small intestine relationship: RO:0002202 UBERON:0001045 {source="Wikipedia"} ! develops from midgut relationship: RO:0002433 UBERON:0002108 ! contributes to morphology of small intestine property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/3/3d/Illu_small_intestine.jpg" xsd:anyURI property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/small-intestine-female/v1.2/assets/3d-vh-f-small-intestine.glb" xsd:anyURI property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/small-intestine-male/v1.2/assets/3d-vh-m-small-intestine.glb" xsd:anyURI property_value: IAO:0000116 "TODO consider ZFA:0001323 mid intestine, see also small intestine" xsd:string property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0002116 name: ileum def: "The portion of the small intestine that extends from the jejunum to the colon." [ISBN:0-683-40008-8, MGI:csmith, MP:0002581] subset: efo_slim subset: human_reference_atlas subset: pheno_slim subset: uberon_slim synonym: "distal intestine" RELATED [BTO:0000620] synonym: "intestinum ileum" RELATED [BTO:0000620] synonym: "lower intestine" RELATED [BTO:0000620] synonym: "posterior intestine" RELATED [Wikipedia:Ileum] xref: AAO:0010403 xref: BTO:0000620 xref: CALOHA:TS-0472 xref: EFO:0001334 xref: EMAPA:32764 xref: EV:0100075 xref: FMA:7208 xref: GAID:315 xref: galen:Ileum xref: MA:0000339 xref: MAT:0000282 xref: MESH:D007082 xref: MIAA:0000282 xref: NCIT:C12387 xref: SCTID:181249005 xref: UMLS:C0020885 {source="ncithesaurus:Ileum"} xref: VHOG:0000647 xref: Wikipedia:Ileum xref: XAO:0000237 is_a: UBERON:0004921 ! subdivision of digestive tract relationship: BFO:0000050 UBERON:0002108 ! part of small intestine relationship: RO:0002433 UBERON:0002108 ! contributes to morphology of small intestine property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/3/3d/Illu_small_intestine.jpg" xsd:anyURI property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/small-intestine-female/v1.2/assets/3d-vh-f-small-intestine.glb" xsd:anyURI property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/small-intestine-male/v1.2/assets/3d-vh-m-small-intestine.glb" xsd:anyURI property_value: IAO:0000116 "TODO consider ZFA:0000706 posterior intestine, see also colon" xsd:string property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0002118 name: right ovary def: "An ovary that is part of a right side of organism [Automatically generated definition]." [OBOL:automatic] xref: EMAPA:37367 {source="MA:th"} xref: FMA:7213 xref: MA:0001705 xref: NCIT:C33487 xref: SCTID:280123002 xref: UMLS:C0227873 {source="ncithesaurus:Right_Ovary"} is_a: UBERON:0000992 ! ovary is_a: UBERON:0015212 ! lateral structure intersection_of: UBERON:0000992 ! ovary intersection_of: BSPO:0000121 UBERON:0000468 ! multicellular organism relationship: BSPO:0000121 UBERON:0000468 ! multicellular organism property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/ovary-female-right/v1.3/assets/3d-vh-f-ovary-r.glb" xsd:anyURI property_value: skos:prefLabel "right ovary" xsd:string [Term] id: UBERON:0002119 name: left ovary def: "An ovary that is part of a left side of organism [Automatically generated definition]." [OBOL:automatic] xref: EMAPA:37366 {source="MA:th"} xref: FMA:7214 xref: MA:0001704 xref: NCIT:C32969 xref: SCTID:280124008 xref: UMLS:C0227874 {source="ncithesaurus:Left_Ovary"} is_a: UBERON:0000992 ! ovary is_a: UBERON:0015212 ! lateral structure intersection_of: UBERON:0000992 ! ovary intersection_of: BSPO:0000120 UBERON:0000468 ! multicellular organism relationship: BSPO:0000120 UBERON:0000468 ! multicellular organism property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/ovary-female-left/v1.3/assets/3d-vh-f-ovary-l.glb" xsd:anyURI property_value: skos:prefLabel "left ovary" xsd:string [Term] id: UBERON:0002120 name: pronephros def: "In mammals, the pronephros is the first of the three embryonic kidneys to be established and exists only transiently. In lower vertebrates such as fish and amphibia, the pronephros is the fully functional embryonic kidney and is indispensible for larval life[GO]." [GO:0048793, Wikipedia:Pronephros] comment: Once the more complex mesonephros forms the pronephros undergoes apoptosis in amphibians. In fishes the nephron degenerates but the organ remains and becomes a component of the immune system[Wikipedia:Pronephros]. // TODO - check developmental relationships. Note that we previously include the ZFA/XAO terms under the more specific 'pronephric kidney', but these are now merged. TODO GCI: relationship: capable_of GO:0030104 subset: efo_slim subset: organ_slim subset: uberon_slim synonym: "archinephron" RELATED [BTO:0001541] synonym: "embryonic kidney" RELATED [BTO:0001541] synonym: "pronephric kidney" EXACT [XAO:0002000] synonym: "pronephron" RELATED [BTO:0001541] xref: AAO:0011089 xref: BTO:0001541 xref: EFO:0000927 xref: EHDAA2:0001570 xref: EHDAA:1017 xref: EMAPA:16579 xref: FMA:72170 xref: MAT:0000117 xref: MIAA:0000117 xref: NCIT:C34280 xref: SCTID:308804007 xref: TAO:0000151 xref: UMLS:C0231048 {source="ncithesaurus:Pronephros"} xref: VHOG:0000037 xref: Wikipedia:Pronephros xref: XAO:0002000 xref: ZFA:0000151 is_a: UBERON:0002113 {source="GO"} ! kidney is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0005423 ! developing anatomical structure relationship: RO:0001025 UBERON:0003887 {source="OG"} ! located in intraembryonic coelom relationship: RO:0002202 UBERON:0005721 {source="ZFA"} ! develops from pronephric mesoderm relationship: RO:0002202 UBERON:0005754 ! develops from rostral part of nephrogenic cord [Term] id: UBERON:0002122 name: capsule of thymus def: "The fibrous connective tissue surrounding the thymus." [MP:0002368] subset: human_reference_atlas subset: pheno_slim synonym: "thymic capsule" EXACT [] synonym: "thymus capsule" EXACT [] xref: EMAPA:19306 xref: FMA:72204 xref: MA:0000766 xref: NCIT:C33770 xref: SCTID:188181003 xref: UMLS:C0229945 {source="ncithesaurus:Thymic_Capsule"} is_a: UBERON:0003893 ! capsule intersection_of: UBERON:0003893 ! capsule intersection_of: RO:0002007 UBERON:0002370 ! bounding layer of thymus relationship: RO:0002007 UBERON:0002370 ! bounding layer of thymus property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0002123 name: cortex of thymus def: "The outer part of a thymus lobule that surrounds the medulla and is composed of closely packed lymphocytes." [ISBN:0-683-40008-8, MP:0002371] subset: human_reference_atlas subset: pheno_slim synonym: "thymic cortex" EXACT [BTO:0002934] synonym: "thymus cortex" EXACT [MA:0000767] xref: BTO:0002934 xref: EMAPA:35863 xref: FMA:72205 xref: MA:0000767 xref: NCIT:C33774 xref: SCTID:188262003 xref: UMLS:C0229948 {source="ncithesaurus:Thymus_Cortex"} xref: Wikipedia:Thymus#Cortex is_a: BFO:0000002 is_a: UBERON:0001851 ! cortex intersection_of: UBERON:0001851 ! cortex intersection_of: BFO:0000050 UBERON:0002370 ! part of thymus relationship: BFO:0000050 UBERON:0002370 ! part of thymus relationship: BFO:0000051 CL:0000542 ! has part lymphocyte relationship: BFO:0000051 CL:0002293 ! has part epithelial cell of thymus relationship: RO:0002216 GO:0045058 ! capable of part of T cell selection property_value: RO:0002175 NCBITaxon:7955 {source="DOI:10.1177/0192623311409597"} property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0002124 name: medulla of thymus def: "Medullary portion of thymus. The reticulum is coarser than in the cortex, the lymphoid cells are relatively fewer in number, and there are found peculiar nest-like bodies, the concentric corpuscles of Hassall. These concentric corpuscles are composed of a central mass, consisting of one or more granular cells, and of a capsule formed of epithelioid cells. They are the remains of the epithelial tubes, which grow out from the third branchial pouches of the embryo to form the thymus. Each follicle is surrounded by a vascular plexus, from which vessels pass into the interior, and radiate from the periphery toward the center, forming a second zone just within the margin of the medullary portion. In the center of the medullary portion there are very few vessels, and they are of minute size." [Wikipedia:Thymus#Medulla] subset: efo_slim subset: human_reference_atlas subset: pheno_slim synonym: "medulla of thymus gland" EXACT [OBOL:automatic] synonym: "thymus gland medulla" EXACT [OBOL:automatic] synonym: "thymus medulla" EXACT [] xref: BTO:0004560 xref: EFO:0001969 xref: EMAPA:19305 xref: FMA:72206 xref: MA:0000771 xref: NCIT:C33775 xref: SCTID:188344009 xref: UMLS:C0229949 {source="ncithesaurus:Thymus_Medulla"} xref: Wikipedia:Thymus#Medulla is_a: UBERON:0000958 ! medulla of organ intersection_of: UBERON:0000958 ! medulla of organ intersection_of: BFO:0000050 UBERON:0002370 ! part of thymus relationship: BFO:0000050 UBERON:0002370 ! part of thymus property_value: RO:0002175 NCBITaxon:7955 {source="DOI:10.1177/0192623311409597"} property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0002125 name: thymus lobule def: "A lobule that is part of a thymus. Divided into an outer cortex and inner medulla and separated from each other by connective tissue septa, but with the medullary tissue continuous from lobule to lobule.[ncit,modified]." [http://orcid.org/0000-0002-6601-2165, ncithesaurus:Thymic_Lobule] subset: human_reference_atlas subset: pheno_slim synonym: "lobule of thymus" EXACT [FMA:72215] synonym: "thymic lobule" EXACT [] synonym: "thymus lobule" EXACT [MA:0000770] xref: FMA:72215 xref: MA:0000770 xref: NCIT:C33772 xref: SCTID:187882006 xref: UMLS:C1522462 {source="ncithesaurus:Thymic_Lobule"} is_a: BFO:0000002 is_a: UBERON:0009911 ! lobule intersection_of: UBERON:0009911 ! lobule intersection_of: BFO:0000050 UBERON:0002370 ! part of thymus relationship: BFO:0000050 UBERON:0005483 ! part of thymus lobe relationship: BFO:0000051 CL:0000235 ! has part macrophage relationship: BFO:0000051 CL:0000432 ! has part reticular cell relationship: BFO:0000051 CL:0000542 ! has part lymphocyte relationship: RO:0002433 UBERON:0002370 ! contributes to morphology of thymus property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0002128 name: superior olivary complex def: "A collection of brainstem nuclei that functions in multiple aspects of hearing and is an important component of the ascending and descending auditory pathways of the auditory system." [ISBN:0-19-502694-2, Wikipedia:Superior_olivary_complex] subset: uberon_slim synonym: "nucleus olivaris superior" EXACT OMO:0003011 [FMA:72247, FMA:TA] synonym: "regio olivaris superioris" RELATED OMO:0003011 [NeuroNames:569] synonym: "superior olivary nuclei" EXACT [FMA:72247] synonym: "superior olivary nucleus" RELATED INCONSISTENT [FMA:72247] synonym: "superior olivary nucleus (Barr & Kiernan)" RELATED [NeuroNames:569] synonym: "superior olive" RELATED INCONSISTENT [FMA:72247, ISBN:0-19-502694-2] xref: BAMS:SOC xref: BIRNLEX:1307 xref: DHBA:12462 xref: EMAPA:35840 xref: EV:0100263 xref: FMA:72247 xref: HBA:9177 xref: MA:0001026 xref: MBA:398 xref: neuronames:569 {source="BIRNLEX:1307"} xref: UMLS:C0175427 {source="BIRNLEX:1307"} xref: VHOG:0001381 xref: Wikipedia:Superior_olivary_complex is_a: UBERON:0007245 ! nuclear complex of neuraxis is_a: UBERON:0019263 ! gray matter of hindbrain relationship: BFO:0000050 UBERON:0003023 {source="NIFSTD"} ! part of pontine tegmentum relationship: BFO:0000050 UBERON:0016490 ! part of auditory system property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/4/46/Gray713.png" xsd:anyURI property_value: skos:prefLabel "superior olivary complex" xsd:string [Term] id: UBERON:0002129 name: cerebellar cortex def: "The superficial gray matter of the cerebellum. It consists of three main layers, the molecular layer, the Purkinje cell layer and the granule cell layer." [BIRNLEX:1566] comment: The circuits in the cerebellar cortex look similar across all classes of vertebrates, including fish, reptiles, birds, and mammals (e.g., Fig. 2). This has been taken as evidence that the cerebellum performs functions important to all vertebrate species. (Wikipedia) subset: human_reference_atlas subset: pheno_slim subset: uberon_slim synonym: "cortex cerebellaris" RELATED [BTO:0000043] synonym: "cortex cerebelli" RELATED OMO:0003011 [NeuroNames:647] synonym: "cortex of cerebellar hemisphere" EXACT [DMBA:CbHCx] xref: BAMS:CB xref: BAMS:CbCx xref: BAMS:CBX xref: BIRNLEX:1566 xref: BM:CB-Cbx xref: BTO:0000043 xref: CALOHA:TS-2000 xref: DHBA:10657 xref: DMBA:16939 xref: EMAPA:35211 xref: EV:0100294 xref: FMA:72248 xref: GAID:596 xref: HBA:4697 xref: MA:0000199 xref: MBA:528 xref: MESH:D002525 xref: NCIT:C49216 xref: neuronames:647 {source="BIRNLEX:1566"} xref: SCTID:361593004 xref: UMLS:C0007759 {source="BIRNLEX:1566", source="ncithesaurus:Cerebellar_Cortex"} xref: UMLS:C1284087 {source="BIRNLEX:1566"} xref: VHOG:0001597 xref: Wikipedia:Cerebellar_cortex is_a: UBERON:0019263 ! gray matter of hindbrain relationship: BFO:0000050 UBERON:0002037 ! part of cerebellum relationship: RO:0002216 GO:0007613 {source="Wikipedia"} ! capable of part of memory relationship: RO:0002433 UBERON:0002037 ! contributes to morphology of cerebellum property_value: foaf:depiction "https://upload.wikimedia.org/wikipedia/commons/a/a7/Cerebellum_NIH.png" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "cerebellar cortex" xsd:string [Term] id: UBERON:0002130 name: cerebellar nuclear complex def: "The gray matter nuclei located in the center of the cerebellum, embedded in the white matter, which receive inhibitory (GABAergic) inputs from Purkinje cells in the cerebellar cortex and excitatory (glutamatergic) inputs from mossy fiber pathways; all output fibers of the cerebellum originate from the these nuclei[MP]." [MP:0009979, Wikipedia:Deep_cerebellar_nuclei] subset: human_reference_atlas subset: uberon_slim synonym: "central nuclei" EXACT [] synonym: "cerebellar nuclei" EXACT [] synonym: "deep cerebellar nuclear complex" EXACT [BIRNLEX:1568] synonym: "deep cerebellar nuclei" EXACT [] synonym: "intracerebellar nuclei" EXACT [] synonym: "intrinsic nuclei of cerebellum" EXACT [] synonym: "nuclei cerebellares" RELATED OMO:0003011 [NeuroNames:682] synonym: "nuclei cerebellaris" RELATED OMO:0003011 [NeuroNames:682] synonym: "nuclei cerebelli" EXACT OMO:0003011 [FMA:72249, FMA:TA] synonym: "nuclei cerebelli" RELATED OMO:0003011 [Wikipedia:Deep_cerebellar_nuclei] synonym: "roof nuclei-2" EXACT [] xref: BAMS:CBN xref: BAMS:CBn xref: BAMS:DCb xref: BAMS:DNC xref: BIRNLEX:1568 xref: DHBA:10660 xref: EV:0100299 xref: FMA:72249 xref: GAID:599 xref: HBA:4780 xref: MBA:519 xref: MESH:D002529 xref: neuronames:682 {source="BIRNLEX:1568"} xref: UMLS:C0007763 {source="BIRNLEX:1568"} xref: Wikipedia:Deep_cerebellar_nuclei is_a: UBERON:0007245 ! nuclear complex of neuraxis is_a: UBERON:0019263 ! gray matter of hindbrain relationship: BFO:0000050 UBERON:0002037 ! part of cerebellum property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/2/23/Gray707.png" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "cerebellar nuclear complex" xsd:string [Term] id: UBERON:0002139 name: subcommissural organ def: "The subcommissural organ is a circumventricular organ consisting of ependymal and hypendymal cells which secrete SCO-spondin[WP,partially vetted]." [PMID:9579598, Wikipedia:Subcommissural_organ] comment: Occurs throughout the vertebartes [PMID:9579598, DOI:10.1002/ar.1091260210]. First appears in hagfish(Olsson). In many species, including the human, it reaches its full development during embryonic life[PMID:9579598]. During the course of phyletic evolution, one notes various changes. Indeed, in lower vertebrates, the SCO presents a greater degree of enzyme activity than the ependyma while in birds the ependyma demonstrates a more intense activity than the SCO[PMID:479574] Sometimes preceded by flexural organ[DOI:10.1007/BF00303086]. Hypendymal cells are rare in non-mammals [PMID:9579598]. {xref="DOI:10.1002/ar.1091260210", xref="PMID:479574", xref="DOI:10.1007/BF00303086", xref="PMID:9579598"} subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "cerebral aqueduct subcommissural organ" RELATED [BAMS:SCO] synonym: "corpus subcommissurale" RELATED OMO:0003011 [NeuroNames:483] synonym: "dorsal subcommissural organ" RELATED [] synonym: "organum subcommissurale" RELATED OMO:0003011 [Wikipedia:Subcommissural_organ] synonym: "SCO" RELATED [] xref: BAMS:SCO xref: BIRNLEX:1028 xref: BTO:0001820 xref: CALOHA:TS-0986 xref: DHBA:12101 xref: DMBA:16514 xref: EMAPA:35828 xref: FMA:72414 xref: GAID:794 xref: HBA:9489 xref: MA:0002941 xref: MESH:D013351 xref: neuronames:483 {source="BIRNLEX:1028"} xref: SCTID:369193006 xref: TAO:0000683 xref: UMLS:C0038533 {source="BIRNLEX:1028"} xref: Wikipedia:Subcommissural_organ xref: ZFA:0000683 is_a: UBERON:0010134 {source="MA"} ! secretory circumventricular organ relationship: BFO:0000050 UBERON:0002314 {source="MA"} ! part of midbrain tectum relationship: BFO:0000050 UBERON:0011357 ! part of Reissner's fiber relationship: BFO:0000051 CL:0000065 ! has part ependymal cell relationship: RO:0003000 PR:000015658 ! produces SCO-spondin property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/d/d7/Gray715.png" xsd:anyURI property_value: RO:0002175 NCBITaxon:7742 {source="multiple"} property_value: skos:prefLabel "subcommissural organ" xsd:string [Term] id: UBERON:0002142 name: pedunculopontine tegmental nucleus def: "The pedunculopontine nucleus (PPN) (or pedunculopontine tegmental nucleus, PPTN) is located in the brainstem, caudal to the substantia nigra and adjacent to the superior cerebellar peduncle. It is composed by a wide variety of neurochemical cell types, including cholinergic, glutamatergic and GABAergic cells. In the classical sense, the PPN is considered to be one of the main components of the reticular activating system. [WP,unvetted]." [https://github.com/obophenotype/mouse-anatomy-ontology/issues/95, Wikipedia:Pedunculopontine_tegmental_nucleus] subset: uberon_slim synonym: "nucleus pedunculopontinus" RELATED OMO:0003011 [NeuroNames:504] synonym: "nucleus tegmenti pedunculopontinus" RELATED OMO:0003011 [NeuroNames:504] synonym: "peduncular pontine nucleus" EXACT [] synonym: "pedunculopontine nucleus" EXACT [] synonym: "PPTg" BROAD OMO:0003000 [BIRNLEX:1437, NIFSTD:NeuroNames_abbrevSource] xref: BAMS:PPN xref: BAMS:PPTg xref: BIRNLEX:1437 xref: BM:Pons-PPT xref: DHBA:12413 xref: DMBA:16965 xref: EMAPA:35672 xref: FMA:72429 xref: HBA:9021 xref: MA:0001020 xref: MBA:1052 xref: neuronames:504 {source="BIRNLEX:1437"} xref: UMLS:C0262306 {source="BIRNLEX:1437"} xref: Wikipedia:Pedunculopontine_tegmental_nucleus is_a: UBERON:0007415 ! nucleus of midbrain reticular formation property_value: skos:prefLabel "pedunculopontine tegmental nucleus" xsd:string [Term] id: UBERON:0002148 name: locus ceruleus def: "The locus ceruleus is a dense cluster of neurons within the dorsorostral pons. This nucleus is the major location of neurons that release norepinephrine throughout the brain, and is responsible for physiological responses to stress and panic[GO]. Bluish region in the superior angle of the fourth ventricle floor, corresponding to melanin-like pigmented nerve cells which lie lateral to the ponto-mesencephalic central gray (griseum centrale). It is also known as nucleus pigmentosus pontis[GAID]." [GAID:577, GO:0021703, Wikipedia:Locus_ceruleus] subset: efo_slim subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "blue nucleus" EXACT [BIRNLEX:905] synonym: "caerulean nucleus" EXACT [] synonym: "loci coeruleus" RELATED OMO:0003004 [ZFA:0000539] synonym: "locus caeruleus" EXACT [BIRNLEX:905] synonym: "locus cinereus" RELATED [BTO:0001408] synonym: "locus coeruleu" EXACT [] synonym: "locus coeruleus" EXACT [] synonym: "locus coeruleus (Vicq d'Azyr)" RELATED [NeuroNames:583] synonym: "Noradrenergic cell group A6" EXACT [Noradrenergic_cell_group_A6&oldid=981960774] synonym: "nucleus caeruleus" EXACT OMO:0003011 [FMA:72478, FMA:TA] synonym: "nucleus loci caerulei" RELATED OMO:0003011 [NeuroNames:583] synonym: "nucleus of locus caeruleus" EXACT [] synonym: "nucleus pigmentosus pontis" EXACT [BIRNLEX:905] synonym: "substantia ferruginea" EXACT [BIRNLEX:905] xref: BAMS:CAE xref: BAMS:LC xref: BIRNLEX:905 xref: BM:Pons-LC xref: BTO:0001408 xref: DHBA:12819 xref: DMBA:16972 xref: EFO:0001963 xref: EMAPA:35502 xref: FMA:72478 xref: GAID:577 xref: HBA:9148 xref: MA:0001017 xref: MBA:147 xref: MESH:D008125 xref: NCIT:C97333 xref: neuronames:583 {source="BIRNLEX:905"} xref: SCTID:369016004 xref: TAO:0000539 xref: UMLS:C0023951 {source="ncithesaurus:Locus_Coeruleus", source="BIRNLEX:905"} xref: Wikipedia:Locus_ceruleus xref: ZFA:0000539 is_a: UBERON:0006331 ! brainstem nucleus is_a: UBERON:0009662 ! hindbrain nucleus is_a: UBERON:8440015 ! noradrenergic cell groups relationship: BFO:0000050 UBERON:0003023 ! part of pontine tegmentum relationship: RO:0002215 GO:0048243 ! capable of norepinephrine secretion property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/7/77/Gray709.png" xsd:anyURI property_value: IAO:0000116 "TODO - check ZFA/pons. also GO says part of dorsorostral pons" xsd:string property_value: skos:prefLabel "locus ceruleus" xsd:string [Term] id: UBERON:0002149 name: superior salivatory nucleus def: "Nucleus containing parasympathetic neurons giving rise to the parasympathetic division of the facial nerve, innervating the salivary glands (Brodal, Neurological Anatomy, 3rd ed., 1981, pg 703)." [BIRNLEX:1131] subset: uberon_slim synonym: "nucleus salivarius superior" RELATED OMO:0003011 [NeuroNames:590] synonym: "nucleus salivatorius cranialis" RELATED OMO:0003011 [NeuroNames:590] synonym: "nucleus salivatorius rostralis" RELATED OMO:0003011 [NeuroNames:590] synonym: "nucleus salivatorius superior" RELATED OMO:0003011 [NeuroNames:590] synonym: "superior salivary nucleus" EXACT [GO:0021753] xref: BAMS:SSN xref: BAMS:SuS xref: BIRNLEX:1131 xref: DHBA:12435 xref: EHDAA2:0004646 xref: EMAPA:37756 {source="MA:th"} xref: FMA:72482 xref: HBA:9194 xref: MA:0001027 xref: MBA:462 xref: neuronames:590 {source="BIRNLEX:1131"} xref: SCTID:369028007 xref: UMLS:C0175447 {source="BIRNLEX:1131"} xref: Wikipedia:Superior_salivatory_nucleus is_a: UBERON:0000126 ! cranial nerve nucleus is_a: UBERON:0004121 ! ectoderm-derived structure is_a: UBERON:0004133 ! salivatory nucleus is_a: UBERON:0007635 ! nucleus of medulla oblongata relationship: BFO:0000050 UBERON:0003023 ! part of pontine tegmentum relationship: RO:0002495 UBERON:0010125 {evidence="definitional"} ! immediate transformation of future superior salivatory nucleus property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/6/6b/Gray788.png" xsd:anyURI property_value: skos:prefLabel "superior salivatory nucleus" xsd:string [Term] id: UBERON:0002151 name: pontine nuclear group def: "Nuclei in the basal pons, intermingled among the descending axons from the cortex, that receive neocrotcial input and give rise to many axons that cross the midline to enter the contralateral cerebellum (Butler and Hodos, Comparative Vertebrate Neuroanatomy, 2nd ed., 2005, pg 135)." [BIRNLEX:1516] subset: human_reference_atlas subset: uberon_slim synonym: "nuclei brachii pontis" RELATED OMO:0003011 [NeuroNames:617] synonym: "nuclei pontis" RELATED OMO:0003011 [BTO:0003396, Wikipedia:Pontine_nuclei] synonym: "nucleus pontis" RELATED OMO:0003011 [NeuroNames:617] synonym: "pontine gray" EXACT [BIRNLEX:1516] synonym: "pontine gray matter" RELATED [BTO:0003396] synonym: "pontine grey matter" RELATED [BAMS:PG] synonym: "pontine nuclear complex" EXACT [BIRNLEX:1516] synonym: "pontine nuclear group" EXACT [FMA:72512] synonym: "pontine nuclei" EXACT [] synonym: "pontine nucleus" EXACT [] xref: BAMS:PG xref: BAMS:Pn xref: BIRNLEX:1516 xref: BM:Pons-PGr xref: BTO:0003396 xref: DHBA:12406 xref: EMAPA:35692 xref: FMA:72512 xref: HBA:9133 xref: MA:0001021 xref: MBA:931 xref: neuronames:617 {source="BIRNLEX:1516"} xref: SCTID:304942009 xref: UMLS:C0228448 {source="BIRNLEX:1516"} xref: Wikipedia:Pontine_nuclei is_a: UBERON:0006331 ! brainstem nucleus is_a: UBERON:0009662 ! hindbrain nucleus relationship: BFO:0000050 UBERON:0002567 ! part of basal part of pons property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/d/dc/Lower_pons_horizontal_KB.svg" xsd:anyURI property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/brain-female/v1.4/assets/3d-allen-f-brain.glb" xsd:anyURI property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/brain-male/v1.4/assets/3d-allen-m-brain.glb" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "pontine nuclear group" xsd:string [Term] id: UBERON:0002152 name: middle cerebellar peduncle def: "Regional part of medullary white matter (according to Neuronames) primarily found at the level of the pons, consisting of a very large bundle of fibers originating in the pontine nuclei projecting to the cerebellum (MM)." [BIRNLEX:1529] subset: human_reference_atlas subset: pheno_slim subset: uberon_slim synonym: "brachium pontis" EXACT [BIRNLEX:1529] synonym: "brachium pontis (stem of middle cerebellar peduncle)" RELATED [BAMS:bp] synonym: "crus cerebelli ad pontem" RELATED OMO:0003011 [NeuroNames:620] synonym: "crus ponto-cerebellare" RELATED OMO:0003011 [NeuroNames:620] synonym: "mid-cerebellar peduncle" RELATED [NeuroNames:620] synonym: "pedunculus cerebellaris medialis" RELATED OMO:0003011 [NeuroNames:620] synonym: "pedunculus cerebellaris medius" RELATED OMO:0003011 [Wikipedia:Middle_cerebellar_peduncle] synonym: "pedunculus cerebellaris pontinus" RELATED OMO:0003011 [NeuroNames:620] xref: BAMS:BP xref: BAMS:bp xref: BAMS:mcp xref: BIRNLEX:1529 xref: BM:Pons-BP xref: DHBA:12768 xref: FMA:72515 xref: HBA:9294 xref: MA:0002745 xref: MBA:78 xref: neuronames:620 {source="BIRNLEX:1529"} xref: NIFSTD_RETIRED:birnlex_1699 xref: SCTID:279219000 xref: UMLS:C0152392 {source="BIRNLEX:1529"} xref: Wikipedia:Middle_cerebellar_peduncle is_a: UBERON:0007416 ! cerebellar peduncle is_a: UBERON:0019292 ! white matter of pons relationship: BFO:0000050 UBERON:0002567 {source="FMA"} ! part of basal part of pons property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/2/2b/Gray705.png" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "middle cerebellar peduncle" xsd:string [Term] id: UBERON:0002162 name: area postrema def: "A small, rounded eminence on each side of the fourth ventricle, which receives nerve fibers from the solitary nucleus , spinal cord, and adjacent areas of the medulla. The area postrema lies outside the blood-brain barrier and its functions include acting as an emetic chemoreceptor." [MESH:A08.186.211.132.810.406.286, Wikipedia:Area_postrema] subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "AP" BROAD OMO:0003000 [BIRNLEX:2636, NIFSTD:NeuroNames_abbrevSource] synonym: "chemoreceptor trigger zone" RELATED [NeuroNames:772] xref: BAMS:AP xref: BIRNLEX:2636 xref: BTO:0003425 xref: DHBA:12807 xref: EMAPA:35143 xref: FMA:72607 xref: GAID:591 xref: HBA:9522 xref: MA:0001034 xref: MBA:207 xref: MESH:D031608 xref: neuronames:772 {source="BIRNLEX:2636"} xref: SCTID:369039005 xref: TAO:0005146 xref: UMLS:C0228530 {source="BIRNLEX:2636"} xref: UMLS:C1289468 {source="BIRNLEX:2636"} xref: Wikipedia:Area_postrema xref: ZFA:0005146 is_a: UBERON:0010135 {source="MA"} ! sensory circumventricular organ relationship: BFO:0000050 UBERON:0001896 {source="MA", source="ZFA"} ! part of medulla oblongata relationship: BFO:0000050 UBERON:0002422 ! part of fourth ventricle property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/7/77/Gray709.png" xsd:anyURI property_value: skos:prefLabel "area postrema" xsd:string [Term] id: UBERON:0002165 name: endocardium def: "The endocardium is an anatomical structure comprised of an endothelium and an extracellular matrix that forms the innermost layer of tissue of the heart, and lines the heart chambers[GO]." [GO:0003157] comment: fixed in GO to reflect FMA. See email to David/Varsha June 18 2010 subset: efo_slim subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "endocardial lining" EXACT [EMAPA:32686] synonym: "endocardial tissue" EXACT [EMAPA:17868] synonym: "heart endocardial tissue" RELATED [VHOG:0000084] synonym: "heart endocardium" EXACT [] xref: AAO:0010408 xref: BTO:0000387 xref: CALOHA:TS-2075 xref: EFO:0000821 xref: EHDAA2:0004153 xref: EMAPA:17868 xref: EMAPA:32686 xref: EV:0100021 xref: FMA:7280 xref: GAID:550 xref: galen:Endocardium xref: MA:0000076 xref: MAT:0000455 xref: MESH:D004699 xref: NCIT:C13004 xref: SCTID:362013006 xref: TAO:0001320 xref: UMLS:C0014124 {source="ncithesaurus:Endocardium"} xref: VHOG:0000084 xref: Wikipedia:Endocardium xref: XAO:0000066 xref: ZFA:0001320 is_a: UBERON:0002523 ! tunica intima is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0005983 ! heart layer relationship: BFO:0000051 UBERON:0005316 ! has part endocardial endothelium relationship: RO:0002495 UBERON:0007280 {source="Bgee:AN"} ! immediate transformation of presumptive endocardium property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/6/6c/Gray493.png" xsd:anyURI property_value: skos:prefLabel "endocardium" xsd:string [Term] id: UBERON:0002166 name: endocardium of atrium def: "Endocardium that is part of the atrium." [ZFIN:curator] subset: pheno_slim subset: vertebrate_core synonym: "atrial endocardium" EXACT [] synonym: "atrium endocardial tissue" RELATED [VHOG:0000606] synonym: "atrium endocardium" EXACT [] synonym: "atrium of heart endocardium" EXACT [OBOL:automatic] synonym: "Cardiac atria endocardium" EXACT [OBOL:automatic] synonym: "cardiac atrium endocardium" EXACT [OBOL:automatic] synonym: "endocardium of atrium of heart" EXACT [OBOL:automatic] synonym: "endocardium of Cardiac atria" EXACT [OBOL:automatic] synonym: "endocardium of cardiac atrium" EXACT [OBOL:automatic] synonym: "endocardium of heart atrium" EXACT [OBOL:automatic] synonym: "heart atrium endocardium" EXACT [OBOL:automatic] xref: EMAPA:32745 xref: FMA:7284 xref: MA:0000077 xref: SCTID:192001005 xref: TAO:0002169 xref: VHOG:0000606 xref: ZFA:0001614 is_a: UBERON:0002165 ! endocardium intersection_of: UBERON:0002165 ! endocardium intersection_of: BFO:0000050 UBERON:0002081 ! part of cardiac atrium relationship: BFO:0000050 UBERON:0002081 ! part of cardiac atrium relationship: RO:0002433 UBERON:0002081 ! contributes to morphology of cardiac atrium property_value: skos:prefLabel "endocardium of atrium" xsd:string [Term] id: UBERON:0002167 name: right lung def: "Lung which consists of the right upper lobe, middle lobe and right lower lobe.[FMA]." [FMA:FMA, Wikipedia:Right_lung] subset: pheno_slim subset: uberon_slim xref: EHDAA2:0001730 xref: EHDAA:4969 xref: EMAPA:17661 xref: FMA:7309 xref: MA:0000426 xref: NCIT:C33483 xref: SCTID:361967000 xref: UMLS:C0225706 {source="ncithesaurus:Right_Lung"} xref: VHOG:0000301 xref: Wikipedia:Right_lung is_a: UBERON:0002048 ! lung intersection_of: UBERON:0002048 ! lung intersection_of: BSPO:0000121 UBERON:0000170 ! pair of lungs relationship: BSPO:0000121 UBERON:0000170 ! pair of lungs property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/3/32/Gray972.png" xsd:anyURI property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/lung-female/v1.4/assets/3d-vh-f-lung.glb" xsd:anyURI property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/lung-male/v1.4/assets/3d-vh-m-lung.glb" xsd:anyURI property_value: skos:prefLabel "right lung" xsd:string [Term] id: UBERON:0002168 name: left lung def: "Lung which consists of the left upper lobe and left lower lobe.[FMA]." [FMA:FMA, Wikipedia:Left_lung] subset: pheno_slim subset: uberon_slim xref: EHDAA2:0000943 xref: EHDAA:4947 xref: EMAPA:17653 xref: FMA:7310 xref: MA:0000425 xref: NCIT:C32967 xref: SCTID:361982005 xref: UMLS:C0225730 {source="ncithesaurus:Left_Lung"} xref: VHOG:0000618 xref: Wikipedia:Left_lung is_a: UBERON:0002048 ! lung intersection_of: UBERON:0002048 ! lung intersection_of: BSPO:0000120 UBERON:0000170 ! pair of lungs relationship: BSPO:0000120 UBERON:0000170 ! pair of lungs property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/d/dd/Gray973.png" xsd:anyURI property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/lung-female/v1.4/assets/3d-vh-f-lung.glb" xsd:anyURI property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/lung-male/v1.4/assets/3d-vh-m-lung.glb" xsd:anyURI property_value: skos:prefLabel "left lung" xsd:string [Term] id: UBERON:0002169 name: alveolar sac def: "The small terminal dilation of the alveolar ducts around which the alveoli form pocket-like clusters." [MP:0010902, Wikipedia:Alveolar_sac] subset: pheno_slim subset: uberon_slim synonym: "air sac" RELATED [MP:0010902] synonym: "pulmonary alveolar sac" EXACT [MP:0010902] synonym: "sacculus alveolaris" EXACT [FMA:7317] xref: BTO:0000061 xref: EMAPA:35119 xref: FMA:7317 xref: MA:0000418 xref: NCIT:C32057 xref: SCTID:361964007 xref: UMLS:C0225691 {source="ncithesaurus:Alveolar_Sac"} xref: Wikipedia:Alveolar_sac is_a: UBERON:0000115 ! lung epithelium is_a: UBERON:0000117 ! respiratory tube is_a: UBERON:0007499 ! epithelial sac intersection_of: UBERON:0007499 ! epithelial sac intersection_of: BFO:0000050 UBERON:0008874 ! part of pulmonary acinus relationship: BFO:0000050 UBERON:0006524 {source="MA"} ! part of alveolar system relationship: BFO:0000050 UBERON:0008874 {source="FMA"} ! part of pulmonary acinus relationship: BFO:0000051 UBERON:0002299 ! has part alveolus of lung relationship: RO:0002433 UBERON:0008874 ! contributes to morphology of pulmonary acinus [Term] id: UBERON:0002173 name: pulmonary alveolar duct def: "The respiratory conducting tubes distal to the respiratory bronchiole that lead to the alveolar sacs and the alveoli." [ISBN:0-683-40008-8, MGI:cwg, MP:0002271] subset: human_reference_atlas subset: pheno_slim subset: uberon_slim synonym: "alveolar duct" EXACT [MA:0000417] synonym: "ductus alveolaris" EXACT OMO:0003011 [FMA:7341, FMA:TA] synonym: "respiratory alveolar duct" EXACT [] xref: EMAPA:32694 xref: FMA:7341 xref: MA:0000417 xref: NCIT:C32056 xref: UMLS:C0391892 {source="ncithesaurus:Alveolar_Duct"} xref: Wikipedia:Alveolar_duct is_a: UBERON:0000117 ! respiratory tube relationship: BFO:0000050 UBERON:0006524 ! part of alveolar system property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/8/8f/Gray975.png" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0002180 name: ventral funiculus of spinal cord def: "The white substance of the spinal cord lying on either side between the ventral median fissure and the ventral roots of the spinal nerves." [http://medical-dictionary.thefreedictionary.com/ventral+funiculus] subset: uberon_slim subset: vertebrate_core synonym: "anterior funiculus" EXACT [] synonym: "anterior funiculus of spinal cord" EXACT [] synonym: "anterior white column of spinal cord" EXACT [FMA:74003] synonym: "funiculus anterior medullae spinalis" EXACT OMO:0003011 [FMA:74003, FMA:TA] synonym: "ventral funiculi" RELATED OMO:0003004 [ZFA:0000605] synonym: "ventral funiculus" EXACT [ZFA:0000605] synonym: "ventral funiculus of spinal cord" EXACT [] synonym: "ventral white column of spinal cord" EXACT [FMA:74003] xref: FMA:74003 xref: neuronames:1304 xref: NLX:379 xref: SCTID:362429007 xref: TAO:0000605 xref: Wikipedia:Ventral_funiculus xref: ZFA:0000605 is_a: UBERON:0006127 ! funiculus of spinal cord is_a: UBERON:0015212 ! lateral structure relationship: BSPO:0000126 UBERON:0002318 {source="FMA-abduced-lr"} ! white matter of spinal cord property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/d/dc/Medulla_spinalis_-_Section_-_English.svg" xsd:anyURI [Term] id: UBERON:0002183 name: lobar bronchus def: "The lobar bronchus is the major airway within the respiratory tree that starts by division of the principal bronchi on both sides and ends at the point of its own subdivision into tertiary or segmental bronchi[GO]." [GO:0060482, Wikipedia:Secondary_bronchus] subset: human_reference_atlas subset: organ_slim subset: uberon_slim synonym: "bronchi lobaris" EXACT OMO:0003011 [Wikipedia:Secondary_bronchus] synonym: "lobar bronchi" RELATED OMO:0003004 [Wikipedia:Secondary_bronchus] synonym: "secondary bronchi" RELATED OMO:0003004 [Wikipedia:Secondary_bronchus] synonym: "secondary bronchus" EXACT [FMA:7406, Wikipedia:Secondary_bronchus] xref: EHDAA:4955 xref: EHDAA:4963 xref: EHDAA:4977 xref: EHDAA:4985 xref: EHDAA:4993 xref: EHDAA:8175 xref: EHDAA:8187 xref: EHDAA:8203 xref: EHDAA:8213 xref: EHDAA:8225 xref: EMAPA:32696 xref: FMA:7406 xref: MA:0000437 xref: NCIT:C32998 xref: SCTID:245509008 xref: UMLS:C0225653 {source="ncithesaurus:Lobar_Bronchus"} xref: Wikipedia:Secondary_bronchus is_a: BFO:0000002 is_a: UBERON:0035767 ! intrapulmonary bronchus relationship: BFO:0000050 UBERON:0000101 {source="FMA"} ! part of lobe of lung relationship: BFO:0000051 UBERON:0001956 ! has part cartilage of bronchus relationship: BFO:0000051 UBERON:0004242 ! has part bronchus smooth muscle relationship: BFO:0000051 UBERON:8410043 ! has part bronchus submucosal gland relationship: distally_connected_to UBERON:0002184 ! segmental bronchus property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/d/df/Illu_quiz_lung05.jpg" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0002184 name: segmental bronchus def: "The tertiary bronchi (also known as the segmental bronchi) arise from the secondary bronchi. The respiratory epithelium lining their lumen is surrounded by a layer of smooth muscle. This layer is composed of two ribbons of smooth muscle that spiral in opposite directions. The smooth muscle layer is surrounded by irregular plates of hyaline cartilage which help maintain the patency of the airway. Each of the tertiary bronchi serves a specific bronchopulmonary segment. There are 10 tertiary bronchi in the right lung, and eight in the left. The tertiary bronchi get smaller and divide into primary bronchioles. [WP,unvetted]." [Wikipedia:Segmental_bronchus] subset: human_reference_atlas subset: organ_slim subset: uberon_slim synonym: "tertiary bronchus" EXACT [] xref: EHDAA:7043 xref: EHDAA:7049 xref: EHDAA:7058 xref: EHDAA:7064 xref: EHDAA:7070 xref: EMAPA:37739 {source="MA:th"} xref: FMA:7407 xref: MA:0000439 xref: NCIT:C33526 xref: SCTID:245513001 xref: UMLS:C0444439 {source="ncithesaurus:Segmental_Bronchus"} xref: VHOG:0001446 xref: Wikipedia:Segmental_bronchus is_a: BFO:0000002 is_a: UBERON:0035767 ! intrapulmonary bronchus relationship: BFO:0000050 UBERON:0000101 {source="FMA"} ! part of lobe of lung relationship: BFO:0000051 UBERON:0001956 ! has part cartilage of bronchus relationship: BFO:0000051 UBERON:0004242 ! has part bronchus smooth muscle relationship: BFO:0000051 UBERON:0004883 ! has part lung mesenchyme relationship: BFO:0000051 UBERON:8410043 ! has part bronchus submucosal gland relationship: proximally_connected_to UBERON:0002183 ! lobar bronchus relationship: RO:0002131 UBERON:8600017 ! overlaps bronchopulmonary segment property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/d/df/Illu_quiz_lung05.jpg" xsd:anyURI property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/lung-female/v1.4/assets/3d-vh-f-lung.glb" xsd:anyURI property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/lung-male/v1.4/assets/3d-vh-m-lung.glb" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0002185 name: bronchus def: "The upper conducting airways of the lung; these airways arise from the terminus of the trachea." [ISBN:0-397-51047-0, MESH:A04.411.125, MGI:cwg, MP:0002264] subset: efo_slim subset: human_reference_atlas subset: organ_slim subset: pheno_slim subset: uberon_slim synonym: "bronchi" EXACT OMO:0003004 [] synonym: "bronchial tissue" RELATED [BTO:0001340] synonym: "bronchial trunk" EXACT [FMA:7409] xref: BTO:0001340 xref: CALOHA:TS-1229 xref: EFO:0000932 xref: EMAPA:32689 xref: EV:0100041 xref: FMA:7409 xref: GAID:346 xref: MA:0000436 xref: MAT:0000133 xref: MESH:D001980 xref: MIAA:0000133 xref: NCIT:C12683 xref: SCTID:181215002 xref: UMLS:C0006255 {source="ncithesaurus:Bronchus"} xref: VHOG:0000262 xref: Wikipedia:Bronchus xref: XAO:0000121 is_a: UBERON:0000117 ! respiratory tube relationship: BFO:0000050 UBERON:0007196 ! part of tracheobronchial tree relationship: RO:0001025 UBERON:0002224 ! located in thoracic cavity property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/1/18/Respiratory_system_complete_numbered.svg" xsd:anyURI property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/lung-female/v1.4/assets/3d-vh-f-lung.glb" xsd:anyURI property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/lung-male/v1.4/assets/3d-vh-m-lung.glb" xsd:anyURI property_value: RO:0002161 NCBITaxon:8507 {source="Wikipedia"} property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "bronchus" xsd:string [Term] id: UBERON:0002186 name: bronchiole def: "The conducting airway of the lungs found terminal to the bronchi; these structures contain neither cartilage nor mucous-secreting glands; the epithelium of the bronchioles becomes thinner with each branching." [ISBN:0-397-51047-0, MGI:cwg, MP:0002267] comment: In some texts/references/ontologies, bronchiole has been used as an exact synonym of 'lobular bronchiole'. However, a 'lobular bronchiole' is a segment of a bronchiole. {xref="https://github.com/obophenotype/uberon/issues/2795"} subset: pheno_slim subset: uberon_slim synonym: "bronchioli" RELATED OMO:0003004 [] synonym: "bronchiolus" RELATED [BTO:0002375] xref: BTO:0002375 xref: CALOHA:TS-2003 xref: EHDAA:8171 xref: EHDAA:8183 xref: EHDAA:8199 xref: EHDAA:8221 xref: EMAPA:32697 xref: FMA:7410 xref: MA:0000422 xref: NCIT:C12684 xref: SCTID:278982001 xref: UMLS:C0006270 {source="ncithesaurus:Bronchiole"} xref: VHOG:0000675 xref: Wikipedia:Bronchiole is_a: UBERON:0000117 ! respiratory tube relationship: BFO:0000050 UBERON:0002048 {source="MA"} ! part of lung relationship: RO:0002380 UBERON:0007196 {source="FMA"} ! branching part of tracheobronchial tree property_value: foaf:depiction "https://upload.wikimedia.org/wikipedia/commons/d/db/Alveoli_diagram.png" xsd:anyURI [Term] id: UBERON:0002187 name: terminal bronchiole def: "A bronchiole that is part of a secondary pulmonary lobule and the last conducting structure of a non-respiratory bronchiole; after this point, the airways have alveoli in their walls." [ISBN:0-397-51047-0, MGI:cwg, MP:0002268, PMID:16543587] subset: human_reference_atlas subset: pheno_slim subset: uberon_slim synonym: "bronchioli terminalis" RELATED OMO:0003011 [Wikipedia:Terminal_bronchiole] synonym: "bronchiolus terminalis" EXACT OMO:0003011 [] synonym: "terminal bronchiole tube" RELATED [] xref: BTO:0003223 xref: EMAPA:36282 xref: FMA:7411 xref: MA:0000424 xref: NCIT:C33754 xref: SCTID:278981008 xref: UMLS:C0225666 {source="ncithesaurus:Terminal_Bronchiole"} xref: Wikipedia:Terminal_bronchiole is_a: UBERON:0002186 ! bronchiole relationship: BFO:0000050 UBERON:0010369 ! part of secondary pulmonary lobule relationship: distally_connected_to UBERON:0002188 ! respiratory bronchiole relationship: distally_connected_to UBERON:0008874 ! pulmonary acinus property_value: foaf:depiction "https://upload.wikimedia.org/wikipedia/commons/d/db/Alveoli_diagram.png" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0002188 name: respiratory bronchiole def: "A bronchiole that is the first segment of the respiratory zone." [ISBN:0123813611, Wikipedia:Respiratory_bronchiole] subset: human_reference_atlas subset: pheno_slim subset: uberon_slim synonym: "bronchiolus respiratorii" EXACT OMO:0003011 [Wikipedia:Respiratory_bronchiole] synonym: "bronchiolus respiratorius" EXACT OMO:0003011 [FMA:7412] xref: BTO:0003222 xref: EMAPA:35729 xref: FMA:7412 xref: MA:0000423 xref: NCIT:C33465 xref: SCTID:128517006 xref: UMLS:C1261270 {source="ncithesaurus:Respiratory_Bronchiole"} xref: Wikipedia:Respiratory_bronchiole is_a: UBERON:0002186 ! bronchiole relationship: BFO:0000050 UBERON:0008874 {source="ISBN:0123813611"} ! part of pulmonary acinus relationship: distally_connected_to UBERON:0002173 ! pulmonary alveolar duct relationship: proximally_connected_to UBERON:0002187 ! terminal bronchiole relationship: RO:0002433 UBERON:0008874 ! contributes to morphology of pulmonary acinus property_value: foaf:depiction "https://upload.wikimedia.org/wikipedia/commons/d/db/Alveoli_diagram.png" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0002190 name: subcutaneous adipose tissue def: "A portion of adipose tissue that is part of the hypodermis, beneath the dermis." [http://orcid.org/0000-0002-6601-2165] subset: human_reference_atlas subset: pheno_slim synonym: "fatty layer of subcutaneous tissue" EXACT [FMA:74315] synonym: "fatty layer of superficial fascia" RELATED [FMA:74315] synonym: "hypodermis fat layer" EXACT [MP:0011156] synonym: "panniculus adiposus" BROAD [MP:0011156] synonym: "panniculus adiposus (tela subcutanea)" EXACT OMO:0003011 [FMA:74315, FMA:TA] synonym: "panniculus adiposus telae subcutaneae" EXACT OMO:0003011 [FMA:74315, FMA:TA] synonym: "subcutaneous fat" RELATED [BTO:0004042] synonym: "subcutaneous fat layer" EXACT [MP:0011156] xref: BTO:0004042 xref: EMAPA:35829 xref: FMA:74315 xref: MA:0000473 xref: MESH:D015434 {sssom:mapping_justification="https://w3id.org/semapv/vocab/LexicalMatching"} is_a: UBERON:0001013 ! adipose tissue intersection_of: UBERON:0001013 ! adipose tissue intersection_of: BFO:0000050 UBERON:0002072 ! part of hypodermis relationship: BFO:0000050 UBERON:0002072 ! part of hypodermis relationship: RO:0002433 UBERON:0002072 ! contributes to morphology of hypodermis property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "subcutaneous adipose tissue" xsd:string [Term] id: UBERON:0002191 name: subiculum def: "Part of the hippocampal formation that is bounded by the entorhinal cortex and area CA1. It is characterized on the CA1 border by an abrupt widening of the pyramidal cell layer. A molecular layer is present that is continuous with that of CA1, although the stratum radiatum is no longer present. The stratum oriens is also not present. adapted from Paxinos, G. The rat central nervous system, 2nd ed, Academic Press, San Diego, 1995, pg. 468)." [BIRNLEX:1305] subset: pheno_slim subset: uberon_slim synonym: "gyrus parahippocampalis" RELATED [BTO:0003087] synonym: "subicular cortex" EXACT [BIRNLEX:1305] synonym: "subiculum cornu ammonis" RELATED [BTO:0003087] synonym: "subiculum hippocampi" EXACT [FMA:74414] xref: BAMS:S xref: BAMS:SUB xref: BIRNLEX:1305 xref: BM:Tel-Cx-SB xref: BTO:0003087 xref: DHBA:10302 xref: DMBA:16163 xref: EMAPA:35832 xref: FMA:74414 xref: HBA:12896 xref: MA:0000960 xref: MBA:502 xref: NCIT:C33648 xref: neuronames:188 xref: PBA:10054 xref: PBA:128012354 xref: SCTID:369097009 xref: UMLS:C0152316 {source="ncithesaurus:Subiculum"} xref: Wikipedia:Subiculum is_a: UBERON:0002616 ! regional part of brain relationship: BFO:0000050 UBERON:0002421 {source="NIFSTD"} ! part of hippocampal formation relationship: RO:0002216 GO:0007613 {source="Wikipedia"} ! capable of part of memory property_value: foaf:depiction "https://upload.wikimedia.org/wikipedia/commons/9/99/Hippocampus.gif" xsd:anyURI property_value: skos:prefLabel "subiculum" xsd:string [Term] id: UBERON:0002193 name: hemolymphoid system def: "Anatomical cluster consisting of the hematopoietic system and the lymphoid system, or its analogs." [http://orcid.org/0000-0002-6601-2165] synonym: "haemolymphoid system" RELATED [] synonym: "hematolymphoid system" EXACT [] synonym: "lymphomyeloid complex" EXACT [] xref: CALOHA:TS-2018 xref: EHDAA2:0004615 xref: EMAPA:18765 xref: FMA:74562 xref: MA:0000013 is_a: UBERON:0000467 {source="MA"} ! anatomical system relationship: RO:0002162 NCBITaxon:33213 ! in taxon Bilateria property_value: skos:prefLabel "hemolymphoid system" xsd:string [Term] id: UBERON:0002194 name: capsule of lymph node def: "Capsule surrounding lymph node composed of connective tissue with some plain muscle fibers." [Wikipedia:Lymph_node#Capsule] subset: human_reference_atlas subset: uberon_slim synonym: "capsula nodi lymphoidei" EXACT OMO:0003011 [FMA:74604, FMA:TA] synonym: "lymph node capsule" EXACT [] xref: EMAPA:35524 xref: FMA:74604 xref: MA:0000739 xref: NCIT:C33028 xref: SCTID:327532004 xref: UMLS:C0229699 {source="ncithesaurus:Lymph_Node_Capsule"} xref: Wikipedia:Lymph_node_capsule is_a: UBERON:0003893 ! capsule intersection_of: UBERON:0003893 ! capsule intersection_of: RO:0002007 UBERON:0000029 ! bounding layer of lymph node relationship: RO:0002007 UBERON:0000029 ! bounding layer of lymph node relationship: RO:0002473 UBERON:0002384 ! composed primarily of connective tissue property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/lymph-node-female/v1.4/assets/3d-nih-f-lymph-node.glb" xsd:anyURI property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/lymph-node-male/v1.4/assets/3d-nih-m-lymph-node.glb" xsd:anyURI property_value: foaf:depiction "https://upload.wikimedia.org/wikipedia/commons/9/92/Lymphknoten_(Schwein).jpg" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0002195 name: trabecula of lymph node def: "Membranous process coming from capsule of lymph node[WP]." [Wikipedia:Lymph_node_trabeculae] subset: human_reference_atlas subset: pheno_slim synonym: "lymph node trabecula" EXACT [] synonym: "lymph node trabeculae" EXACT OMO:0003004 [] synonym: "lymph node trabeculum" EXACT [] synonym: "trabeculae of lymph node" EXACT OMO:0003004 [] xref: FMA:74605 xref: MA:0000746 xref: NCIT:C33035 xref: UMLS:C1184179 {source="ncithesaurus:Lymph_Node_Trabecula"} xref: Wikipedia:Lymph_node_trabeculae is_a: UBERON:0000440 ! trabecula intersection_of: UBERON:0000440 ! trabecula intersection_of: BFO:0000050 UBERON:0000029 ! part of lymph node relationship: BFO:0000050 UBERON:0000029 ! part of lymph node property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/b/b3/Gray598.png" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0002196 name: adenohypophysis def: "The glandular, anterior lobe of the pituitary gland. The anterior pituitary regulates several physiological processes including stress, growth, and reproduction[WP]. The anterior lobe of the hypophysis (pituitary gland). This lobe contains cells that produce prolactin, growth hormone, thyroid-stimulating hormone, follicle-stimulating hormone and proopiomelanocortin[ZFA]." [Wikipedia:Adenohypophysis, ZFIN:curator] subset: efo_slim subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "AHP" BROAD OMO:0003000 [BIRNLEX:1581, NIFSTD:NeuroNames_abbrevSource] synonym: "anterior hypophysis" EXACT [ZFA:0001282] synonym: "anterior lobe (hypophysis)" EXACT [] synonym: "anterior lobe of hypophysis" EXACT [] synonym: "anterior lobe of pituitary" EXACT [] synonym: "anterior lobe of pituitary gland" EXACT [] synonym: "anterior lobe of the pituitary" RELATED [BAMS:APit] synonym: "anterior pituitary" EXACT [] synonym: "anterior pituitary gland" RELATED [BTO:0000040] synonym: "cranial lobe" RELATED [BTO:0000496] synonym: "lobus anterior" RELATED OMO:0003011 [NeuroNames:407] synonym: "lobus anterior (glandula pituitaria)" EXACT OMO:0003011 [FMA:74627, FMA:TA] synonym: "lobus anterior hypophysis" EXACT OMO:0003011 [FMA:74627, FMA:TA] synonym: "pituitary anterior lobe" RELATED [EMAPA:17514] synonym: "pituitary gland, anterior lobe" EXACT [] synonym: "pituitary glandanterior lobe" RELATED [BAMS:AL] synonym: "rostral lobe" RELATED [BTO:0000496] xref: AAO:0010540 xref: BAMS:AHY xref: BAMS:AL xref: BAMS:APit xref: BIRNLEX:1581 xref: BM:AHy xref: BTO:0000040 xref: CALOHA:TS-0794 xref: EFO:0000230 xref: EHDAA2:0000109 xref: EMAPA:17514 xref: FMA:74627 xref: MA:0000177 xref: MESH:D010903 xref: NCIT:C12772 xref: neuronames:407 {source="BIRNLEX:1581"} xref: SCTID:245532007 xref: TAO:0001282 xref: UMLS:C0032008 {source="ncithesaurus:Anterior_Lobe_of_the_Pituitary_Gland", source="BIRNLEX:1581"} xref: UMLS:C1280369 {source="BIRNLEX:1581"} xref: VHOG:0000141 xref: Wikipedia:Adenohypophysis xref: ZFA:0001282 is_a: UBERON:0000064 ! organ part is_a: UBERON:0004121 ! ectoderm-derived structure is_a: UBERON:0005156 ! reproductive structure disjoint_from: UBERON:0002198 {source="lexical"} ! neurohypophysis relationship: BFO:0000050 UBERON:0000007 ! part of pituitary gland relationship: BFO:0000051 CL:0000438 ! has part luteinizing hormone secreting cell relationship: BFO:0000051 CL:0000439 {source="ZFA"} ! has part prolactin secreting cell relationship: BFO:0000051 CL:0000467 {source="ZFA"} ! has part adrenocorticotropic hormone secreting cell relationship: BFO:0000051 CL:0002312 ! has part somatotroph relationship: RO:0002202 UBERON:0009122 {source="NCBIBook:NBK53175", source="ZFA"} ! develops from adenohypophyseal placode relationship: RO:0002433 UBERON:0000007 ! contributes to morphology of pituitary gland property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/f/fb/Gray1181.png" xsd:anyURI property_value: skos:prefLabel "adenohypophysis" xsd:string [Term] id: UBERON:0002197 name: median eminence of neurohypophysis def: "Elevation on the ventral surface of the brain located at the zone of attachment between the hypothalamic floor and the hypophysis (Butler and Hodos, Comparative Vertebrate Neuroanatomy, 2nd ed., 2005, pg. 446)." [BIRNLEX:925] subset: pheno_slim subset: uberon_slim synonym: "eminentia medialis (Shantha)" RELATED OMO:0003011 [NeuroNames:402] synonym: "eminentia mediana" RELATED OMO:0003011 [NeuroNames:402] synonym: "eminentia mediana hypothalami" EXACT OMO:0003011 [FMA:74634, FMA:TA] synonym: "eminentia mediana hypothalami" RELATED OMO:0003011 [Wikipedia:Median_eminence] synonym: "eminentia postinfundibularis" RELATED OMO:0003011 [NeuroNames:402] synonym: "ME" BROAD OMO:0003000 [BIRNLEX:925, NIFSTD:NeuroNames_abbrevSource] synonym: "medial eminence" RELATED [NeuroNames:402] synonym: "median eminence" EXACT [] synonym: "median eminence of hypothalamus" EXACT [] synonym: "median eminence of posterior lobe of pituitary gland" EXACT [] synonym: "median eminence of tuber cinereum" EXACT [] xref: AAO:0010539 xref: BAMS:ME xref: BIRNLEX:925 xref: BM:ME xref: BTO:0001954 xref: DHBA:13338 xref: DMBA:15689 xref: EHDAA2:0001080 xref: EHDAA:7540 xref: EMAPA:17521 xref: FMA:74634 xref: GAID:463 xref: HBA:12916 xref: MA:0000859 xref: MBA:10671 xref: MESH:D008473 xref: neuronames:402 {source="BIRNLEX:925"} xref: SCTID:369121004 xref: UMLS:C0025056 {source="BIRNLEX:925"} xref: VHOG:0001179 xref: Wikipedia:Median_eminence is_a: UBERON:0003296 ! gland of diencephalon is_a: UBERON:0003937 ! reproductive gland is_a: UBERON:0010134 ! secretory circumventricular organ relationship: BFO:0000050 UBERON:0002198 ! part of neurohypophysis relationship: RO:0002162 NCBITaxon:8287 {source="ISBN:0471888893"} ! in taxon Sarcopterygii property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/8/8c/HypothalamicNuclei.PNG" xsd:anyURI property_value: skos:prefLabel "median eminence of neurohypophysis" xsd:string [Term] id: UBERON:0002198 name: neurohypophysis def: "The posterior part of the pituitary gland that secretes hormones involved in blood pressure regulation such as oxytocin and antidiuretic hormon." [MP:0004164] subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "infundibular process" EXACT [FMA:74628] synonym: "lobus nervosus" RELATED OMO:0003011 [NeuroNames:401] synonym: "lobus nervosus neurohypophysis" EXACT OMO:0003011 [FMA:74628, FMA:TA] synonym: "lobus posterior" RELATED OMO:0003011 [NeuroNames:401] synonym: "lobus posterior (glandula pituitaria)" EXACT OMO:0003011 [FMA:74628, FMA:TA] synonym: "lobus posterior hypophysis" EXACT OMO:0003011 [FMA:74628, FMA:TA] synonym: "neural lobe" EXACT [FMA:74628] synonym: "neural lobe of pituitary" EXACT [BIRNLEX:1586] synonym: "neural lobe of pituitary gland" EXACT [FMA:74628] synonym: "neuro hypophysis" EXACT [] synonym: "neurohypophysis" EXACT [] synonym: "NHP" BROAD OMO:0003000 [BIRNLEX:1586, NIFSTD:NeuroNames_abbrevSource] synonym: "pituitary gland neural lobe" RELATED [BAMS:NL] synonym: "pituitary gland, neural lobe" RELATED [NeuroNames:401] synonym: "pituitary gland, posterior lobe" EXACT [] synonym: "posterior lobe of hypophysis" RELATED [NeuroNames:401] synonym: "posterior lobe of pituitary" EXACT [] synonym: "posterior lobe of pituitary gland" EXACT [FMA:74628] synonym: "posterior pituitary" EXACT [] synonym: "posterior pituitary gland" RELATED [BTO:0000937] xref: AAO:0010537 xref: BAMS:NHP xref: BAMS:NHY xref: BAMS:NL xref: BAMS:PPit xref: BIRNLEX:1586 xref: BM:NY xref: BTO:0000937 xref: CALOHA:TS-0815 xref: DMBA:15691 xref: EHDAA2:0001271 xref: EHDAA:7536 xref: EMAPA:17519 xref: FMA:74628 xref: MA:0000178 xref: MESH:D010904 xref: NCIT:C12773 xref: neuronames:401 {source="BIRNLEX:1586"} xref: SCTID:245527006 xref: TAO:0001271 xref: UMLS:C0032009 {source="ncithesaurus:Posterior_Lobe_of_the_Pituitary_Gland", source="BIRNLEX:1586"} xref: UMLS:C1280368 {source="BIRNLEX:1586"} xref: VHOG:0000142 xref: Wikipedia:Neurohypophysis xref: ZFA:0001271 is_a: UBERON:0003296 ! gland of diencephalon is_a: UBERON:0003937 ! reproductive gland is_a: UBERON:0004121 ! ectoderm-derived structure is_a: UBERON:0010134 {source="MA"} ! secretory circumventricular organ relationship: BFO:0000050 UBERON:0000007 {source="ZFA"} ! part of pituitary gland relationship: RO:0002202 UBERON:0002346 ! develops from neurectoderm relationship: RO:0002215 GO:0001992 {source="Wikipedia"} ! capable of regulation of systemic arterial blood pressure by vasopressin relationship: RO:0002215 GO:0030103 {source="Wikipedia"} ! capable of vasopressin secretion property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/b/b9/Pituitary_gland_representation.PNG" xsd:anyURI property_value: IAO:0000116 "request magnocellular cell from CL. Request oxytocin secretion from GO. Notes: 'The hypophysis or pituitary gland is derived, in part from an ectodermal outpocketing of the stomodeum (Rathke's Pouch) and in part from the floor of the diencephalon'" xsd:string {source="http://syllabus.med.unc.edu/courseware/embryo_images/"} property_value: RO:0002175 NCBITaxon:117569 {source="Ariens, p. 1192"} property_value: skos:prefLabel "neurohypophysis" xsd:string [Term] id: UBERON:0002199 name: integument def: "The dermis, epidermis and hypodermis." [Wikipedia:Integument] subset: human_reference_atlas subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "dermal system" RELATED [BTO:0000634] synonym: "dermis plus epidermis plus hypodermis" EXACT [] synonym: "dermoid system" RELATED [BTO:0000634] synonym: "integumentum commune" EXACT OMO:0003011 [FMA:74657, FMA:TA] synonym: "skin" RELATED [] synonym: "skin and subcutaneous tissue" EXACT [] synonym: "skin plus hypodermis" EXACT [] synonym: "tegument" RELATED [BTO:0000634] synonym: "the integument" EXACT [FMA:74657] synonym: "vertebrate integument" RELATED [] xref: AAO:0000239 xref: BTO:0000634 xref: EMAPA:37504 {source="MA:th"} xref: FMA:74657 xref: galen:Integument xref: TAO:0000368 xref: VSAO:0000029 xref: Wikipedia:Integument xref: ZFA:0000368 is_a: UBERON:0010314 ! structure with developmental contribution from neural crest is_a: UBERON:0011216 {source="FMA"} ! organ system subdivision relationship: BFO:0000050 UBERON:0002416 {source="FMA"} ! part of integumental system relationship: BFO:0000051 UBERON:0002072 ! has part hypodermis relationship: BFO:0000051 UBERON:0002097 ! has part skin of body relationship: RO:0002007 UBERON:0000468 ! bounding layer of multicellular organism property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "integument" xsd:string [Term] id: UBERON:0002200 name: vasculature of head def: "Vasculature that is part of a head [Automatically generated definition]." [OBOL:automatic] subset: efo_slim subset: vertebrate_core synonym: "adult head vascular network" EXACT [OBOL:automatic] synonym: "adult head vasculature" EXACT [OBOL:automatic] synonym: "cranial vasculature" EXACT [] synonym: "head vascular network" EXACT [OBOL:automatic] synonym: "head vasculature" RELATED [] synonym: "vascular network of adult head" EXACT [OBOL:automatic] synonym: "vascular network of head" EXACT [OBOL:automatic] synonym: "vasculature of adult head" EXACT [OBOL:automatic] xref: EFO:0003656 xref: FMA:74710 xref: TAO:0001267 xref: XAO:0004152 xref: ZFA:0001267 is_a: UBERON:0002049 ! vasculature intersection_of: UBERON:0002049 ! vasculature intersection_of: BFO:0000050 UBERON:0000033 ! part of head relationship: BFO:0000050 UBERON:0000033 ! part of head property_value: skos:prefLabel "vasculature of head" xsd:string [Term] id: UBERON:0002201 name: vasculature of trunk def: "A vasculature that is part of a trunk [Automatically generated definition]." [OBOL:automatic] subset: vertebrate_core synonym: "torso vascular network" EXACT [OBOL:automatic] synonym: "torso vasculature" EXACT [OBOL:automatic] synonym: "trunk vascular network" EXACT [OBOL:automatic] synonym: "trunk vasculature" EXACT [] synonym: "vascular network of torso" EXACT [OBOL:automatic] synonym: "vascular network of trunk" EXACT [OBOL:automatic] synonym: "vasculature of torso" EXACT [OBOL:automatic] xref: FMA:74712 xref: TAO:0005024 xref: ZFA:0005024 is_a: UBERON:0002049 ! vasculature intersection_of: UBERON:0002049 ! vasculature intersection_of: BFO:0000050 UBERON:0002100 ! part of trunk relationship: BFO:0000050 UBERON:0002100 ! part of trunk property_value: skos:prefLabel "vasculature of trunk" xsd:string [Term] id: UBERON:0002202 name: submucosa of trachea def: "A submucosa that is part of a trachea." [OBOL:automatic] subset: human_reference_atlas subset: pheno_slim synonym: "submucosa of windpipe" EXACT [OBOL:automatic] synonym: "submucous layer of trachea" RELATED [BTO:0002115] synonym: "trachea submucosa" EXACT [] synonym: "tracheal submucosa" EXACT [] synonym: "windpipe submucosa" EXACT [OBOL:automatic] xref: BTO:0002115 xref: EMAPA:35879 xref: FMA:7472 xref: MA:0001860 xref: NCIT:C49307 xref: SCTID:4419000 xref: UMLS:C0225586 {source="ncithesaurus:Trachea_Submucosa"} is_a: UBERON:0004777 ! respiratory system submucosa intersection_of: UBERON:0000009 ! submucosa intersection_of: BFO:0000050 UBERON:0003126 ! part of trachea relationship: BFO:0000050 UBERON:0003126 ! part of trachea property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "submucosa of trachea" xsd:string [Term] id: UBERON:0002203 name: vasculature of eye def: "Vasculature that is part of the eye region." [https://sourceforge.net/tracker/?func=detail&aid=3489658&group_id=76834&atid=994726, OBOL:automatic] subset: human_reference_atlas subset: pheno_slim subset: vertebrate_core synonym: "eye vascular network" EXACT [OBOL:automatic] synonym: "eye vasculature" RELATED [] synonym: "ocular blood vessel" EXACT [ZFA:0007057] synonym: "ocular vasculature" EXACT [] synonym: "optic vasculature" RELATED [] synonym: "vascular network of eye" EXACT [OBOL:automatic] xref: FMA:74743 xref: SCTID:123846009 xref: TAO:0007057 xref: ZFA:0007057 is_a: BFO:0000002 is_a: UBERON:0002200 ! vasculature of head is_a: UBERON:0006876 ! vasculature of organ intersection_of: UBERON:0002049 ! vasculature intersection_of: BFO:0000050 UBERON:0000019 ! part of camera-type eye relationship: BFO:0000050 UBERON:0000019 ! part of camera-type eye relationship: RO:0002202 UBERON:0003314 {source="ISBN:0781772214"} ! develops from eye mesenchyme property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/blood-vasculature-female/v1.3/assets/3d-vh-f-blood-vasculature.glb" xsd:anyURI property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/blood-vasculature-male/v1.3/assets/3d-vh-m-blood-vasculature.glb" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "vasculature of eye" xsd:string [Term] id: UBERON:0002204 name: musculoskeletal system def: "Anatomical system that consists of the muscular and skeletal systems." [https://github.com/obophenotype/uberon/issues/77, VSAO:0000031, VSAO:curator] subset: uberon_slim synonym: "musculo-skeletal system" EXACT [] xref: AAO:0010546 xref: CALOHA:TS-1311 xref: EMAPA:32714 xref: EV:0100139 xref: FMA:7482 xref: GAID:98 xref: MA:0002418 xref: MESH:D009141 xref: NCIT:C12754 xref: SCTID:278858007 xref: UMLS:C0026860 {source="ncithesaurus:Musculoskeletal_System"} xref: VHOG:0001275 xref: VSAO:0000031 xref: Wikipedia:Musculoskeletal_system xref: XAO:0000168 is_a: BFO:0000002 is_a: UBERON:0000467 ! anatomical system disjoint_from: UBERON:0002294 ! biliary system disjoint_from: UBERON:0002330 ! exocrine system disjoint_from: UBERON:0002390 ! hematopoietic system disjoint_from: UBERON:0002405 ! immune system disjoint_from: UBERON:0002416 ! integumental system disjoint_from: UBERON:0002423 ! hepatobiliary system disjoint_from: UBERON:0004456 ! entire sense organ system disjoint_from: UBERON:8450002 ! excretory system relationship: BFO:0000051 UBERON:0000383 ! has part musculature of body relationship: BFO:0000051 UBERON:0001434 ! has part skeletal system relationship: RO:0002216 GO:0040011 ! capable of part of locomotion relationship: RO:0002492 UBERON:0000066 ! existence ends during fully formed stage property_value: skos:prefLabel "musculoskeletal system" xsd:string property_value: terms:contributor https://orcid.org/0000-0002-6601-2165 [Term] id: UBERON:0002206 name: mammillary body def: "One of two hemispherical bulges on the base of the posterior hypothalamus (Butler and Hodos, Comparative Vertebrate Neuroanatomy, 2nd ed., 2005, pg 455)." [BIRNLEX:865] subset: human_reference_atlas subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "corpora mamillaria" RELATED OMO:0003011 [NeuroNames:412] synonym: "corpora mammillaria" RELATED OMO:0003011 [NeuroNames:412] synonym: "corpus mamillare" EXACT [ZFA:0000334] synonym: "corpus mamillare" RELATED OMO:0003011 [Wikipedia:Mammillary_body] synonym: "corpus mamillaris" RELATED OMO:0003011 [NeuroNames:412] synonym: "corpus mammillare" RELATED OMO:0003011 [NeuroNames:412] synonym: "mammillary area" RELATED [DMBA:Mam] synonym: "MMB" BROAD OMO:0003000 [BIRNLEX:865, NIFSTD:NeuroNames_abbrevSource] xref: BAMS:MB xref: BAMS:MBO xref: BAMS:mmb xref: BIRNLEX:865 xref: DHBA:15546 xref: DMBA:15723 xref: EMAPA:35542 xref: FMA:74877 xref: GAID:652 xref: HBA:12909 xref: MA:0000174 xref: MBA:331 xref: MESH:D008326 xref: NCIT:C33052 xref: neuronames:412 {source="BIRNLEX:865"} xref: SCTID:279306001 xref: TAO:0000334 xref: UMLS:C0024670 {source="BIRNLEX:865", source="ncithesaurus:Mamillary_Body"} xref: UMLS:C1305759 {source="BIRNLEX:865"} xref: Wikipedia:Mammillary_body xref: ZFA:0000334 is_a: UBERON:0000064 ! organ part relationship: BFO:0000050 UBERON:0002272 {source="ABA"} ! part of medial zone of hypothalamus relationship: BFO:0000050 UBERON:0002770 {source="GO definition"} ! part of posterior hypothalamic region relationship: RO:0002433 UBERON:0001894 ! contributes to morphology of diencephalon property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/9/97/Gray1180.png" xsd:anyURI property_value: RO:0002175 NCBITaxon:117569 {source="Hardisty, p. 320-1"} property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "mammillary body" xsd:string [Term] id: UBERON:0002209 name: fibrous joint def: "Nonsynovial joint in which the articulating bones or cartilages are connected by ligaments. Examples: sagittal suture, inferior tibiofibular syndesmosis, gomphosis.[FMA]." [FMA:FMA, Wikipedia:Fibrous_joint] subset: uberon_slim subset: vertebrate_core synonym: "articulatio fibrosa" EXACT [] synonym: "junctura fibrosa" RELATED OMO:0003011 [Wikipedia:Fibrous_joint] xref: AEO:0000178 xref: EHDAA2:0003178 xref: EMAPA:35344 xref: FMA:7492 xref: MA:0000321 xref: SCTID:37772004 xref: TAO:0005156 xref: Wikipedia:Fibrous_joint xref: ZFA:0005156 is_a: UBERON:0011134 {source="FMA"} ! nonsynovial joint relationship: BFO:0000051 CL:0002320 {source="AEO"} ! has part connective tissue cell property_value: skos:prefLabel "fibrous joint" xsd:string [Term] id: UBERON:0002210 name: syndesmosis def: "Fibrous joint in which the articulating bones or cartilages of the vertebral column and the limbs as well as articulating ossicles, are connected by skeletal ligaments or membranes. Examples: Intervertebral syndesmosis, inferior tibiofibular joint.[FMA]." [FMA:FMA, Wikipedia:Syndesmosis] subset: uberon_slim xref: EMAPA:37465 {source="MA:th"} xref: FMA:7494 xref: MA:0001500 xref: SCTID:89358004 xref: Wikipedia:Syndesmosis is_a: UBERON:0002209 ! fibrous joint is_a: UBERON:0002213 ! cartilaginous joint [Term] id: UBERON:0002211 name: nerve root def: "A continuation of the neuron projection bundle component of a nerve inside, crossing or immediately outside the central nervous system." [http://orcid.org/0000-0002-6601-2165, https://github.com/obophenotype/uberon/issues/286] subset: human_reference_atlas subset: uberon_slim synonym: "initial segment of nerve" EXACT [http://orcid.org/0000-0002-6601-2165] synonym: "radix nervi" EXACT OMO:0003011 [] xref: FMA:5981 xref: FMA:82524 xref: NCIT:C54024 xref: NLX:144250 xref: SCTID:362295007 xref: UMLS:C0228084 {source="ncithesaurus:Nerve_Root"} xref: Wikipedia:Nerve_root is_a: UBERON:0000122 ! neuron projection bundle relationship: extends_fibers_into UBERON:0001017 ! central nervous system relationship: extends_fibers_into UBERON:0001021 ! nerve property_value: IAO:0000116 "We consider cranial nerve roots to be primarily CNS structures, but model spinal nerve roots as PNS structures, due to the existence of ganglia on the roots." xsd:string property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "nerve root" xsd:string [Term] id: UBERON:0002212 name: macula of saccule of membranous labyrinth def: "The oval neuroepithelial sensory receptor in the anterior wall of the saccule; hair cells of the neuroepithelium support the statoconial membrane and have terminal arborizations of vestibular nerve fibers around their bodies." [MGI:anna, MP:0004330] subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "macula of membranous labyrinth saccule" EXACT [OBOL:automatic] synonym: "macula of saccule" EXACT [] synonym: "macula of sacculus (labyrinthus vestibularis)" EXACT [OBOL:automatic] synonym: "macula saccule" EXACT [ZFA:0007000] synonym: "macula sacculi" EXACT OMO:0003011 [FMA:74944, FMA:TA] synonym: "macula sacculi" RELATED OMO:0003011 [Wikipedia:Macula_of_saccule] synonym: "membranous labyrinth saccule macula" EXACT [OBOL:automatic] synonym: "saccular macula" EXACT [ZFA:0007000] synonym: "saccular macula of membranous labyrinth" EXACT [] synonym: "saccular maculs" RELATED [] synonym: "saccule macula" EXACT [OBOL:automatic] synonym: "saccule of membranous labyrinth macula" EXACT [OBOL:automatic] synonym: "sacculus (labyrinthus vestibularis) macula" EXACT [OBOL:automatic] xref: EMAPA:35534 xref: FMA:74944 xref: MA:0001201 xref: NCIT:C33045 xref: SCTID:362572004 xref: TAO:0007000 xref: UMLS:C0229468 {source="ncithesaurus:Macula_of_Saccule"} xref: Wikipedia:Macula_of_saccule xref: XAO:0004136 xref: ZFA:0007000 is_a: UBERON:0000054 ! macula intersection_of: UBERON:0000054 ! macula intersection_of: BFO:0000050 UBERON:0001854 ! part of saccule of membranous labyrinth relationship: BFO:0000050 UBERON:0001854 ! part of saccule of membranous labyrinth relationship: RO:0002433 UBERON:0001854 ! contributes to morphology of saccule of membranous labyrinth [Term] id: UBERON:0002213 name: cartilaginous joint def: "Nonsynovial joint in which the articulating bones or cartilages are connected by cartilage. Examples: Spheno-occipital synchondrosis, first sternocostal joint, pubic symphysis.[FMA]." [FMA:FMA, Wikipedia:Cartilaginous_joint] subset: uberon_slim subset: vertebrate_core synonym: "articulatio cartilaginea" EXACT [] synonym: "junctura cartilaginea" RELATED OMO:0003011 [Wikipedia:Cartilaginous_joint] xref: EMAPA:36581 xref: FMA:7496 xref: MA:0000320 xref: SCTID:58442004 xref: TAO:0005155 xref: Wikipedia:Cartilaginous_joint xref: ZFA:0005155 is_a: BFO:0000002 is_a: UBERON:0011134 {source="FMA"} ! nonsynovial joint intersection_of: UBERON:0011134 ! nonsynovial joint intersection_of: RO:0002473 UBERON:0002418 ! composed primarily of cartilage tissue relationship: RO:0002473 UBERON:0002418 ! composed primarily of cartilage tissue property_value: skos:prefLabel "cartilaginous joint" xsd:string [Term] id: UBERON:0002214 name: macula of utricle of membranous labyrinth def: "The neuroepithelial sensory receptor in the inferolateral wall of the utricle; hair cells of the neuroepithelium support the statoconial membrane and have terminal arborizations of vestibular nerve fibers around their bodies; normally sensitive to linear acceleration in the longitudinal axis of the body and to gravitational influences." [MGI:anna, MP:0004333] subset: efo_slim subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "macula of membranous labyrinth utricle" EXACT [OBOL:automatic] synonym: "macula of utricle" EXACT [] synonym: "macula of utriculus (labyrinthus vestibularis)" EXACT [OBOL:automatic] synonym: "macula utricle" EXACT [ZFA:0000030] synonym: "macula utriculi" EXACT OMO:0003011 [FMA:74960, FMA:TA] synonym: "macula utriculi" RELATED OMO:0003011 [Wikipedia:Macula_of_utricle] synonym: "maculae utricle" RELATED OMO:0003004 [ZFA:0000030] synonym: "membranous labyrinth utricle macula" EXACT [OBOL:automatic] synonym: "utricle macula" EXACT [OBOL:automatic] synonym: "utricle of membranous labyrinth macula" EXACT [OBOL:automatic] synonym: "utricular macula" RELATED [] synonym: "utriculus (labyrinthus vestibularis) macula" EXACT [OBOL:automatic] xref: EFO:0003474 xref: EMAPA:35535 xref: FMA:74960 xref: MA:0001203 xref: NCIT:C33046 xref: SCTID:362568003 xref: TAO:0000030 xref: UMLS:C0229451 {source="ncithesaurus:Macula_of_Utricle"} xref: Wikipedia:Macula_of_utricle xref: ZFA:0000030 is_a: UBERON:0000054 ! macula intersection_of: UBERON:0000054 ! macula intersection_of: BFO:0000050 UBERON:0001853 ! part of utricle of membranous labyrinth relationship: BFO:0000050 UBERON:0001853 ! part of utricle of membranous labyrinth relationship: RO:0002433 UBERON:0001853 ! contributes to morphology of utricle of membranous labyrinth property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/c/cb/Bigotolith.jpg" xsd:anyURI [Term] id: UBERON:0002215 name: synchondrosis def: "Cartilaginous joint in which the articulating bones or cartilages are connected by hyaline cartilage. Examples: spheno-occipital synchondrosis, first sternocostal joint.[FMA]." [FMA:FMA, Wikipedia:Synchondrosis] subset: pheno_slim subset: uberon_slim synonym: "cartilago epiphysialis" EXACT OMO:0003011 [FMA:7497, FMA:TA] synonym: "epiphysial cartilage" RELATED [FMA:7497] synonym: "primary cartilaginous joint" EXACT [FMA:7497] xref: EMAPA:35846 xref: FMA:7497 xref: MA:0001501 xref: SCTID:42903008 xref: Wikipedia:Synchondrosis is_a: UBERON:0002209 ! fibrous joint is_a: UBERON:0002213 ! cartilaginous joint intersection_of: UBERON:0002209 ! fibrous joint intersection_of: RO:0002473 UBERON:0001994 ! composed primarily of hyaline cartilage tissue relationship: RO:0002473 UBERON:0001994 ! composed primarily of hyaline cartilage tissue property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/7/76/Gray297.png" xsd:anyURI property_value: IAO:0000116 "consider adding link to hyaline cartilage" xsd:string property_value: IAO:0000116 "WP considers epiphyseal plates as subtypes of this" xsd:string property_value: skos:prefLabel "synchondrosis" xsd:string [Term] id: UBERON:0002216 name: symphysis def: "Cartilaginous joint in which the articulating bones or cartilages are connected by fibrocartilage. Examples: pubic symphysis, intervertebral symphysis, manubriosternal joint.[FMA]." [FMA:FMA, Wikipedia:Symphysis] subset: uberon_slim synonym: "secondary cartilaginous joint" EXACT [FMA:7498] xref: EMAPA:37758 {source="MA:th"} xref: FMA:7498 xref: MA:0001504 xref: SCTID:1584001 xref: Wikipedia:Symphysis is_a: UBERON:0002209 {source="MA"} ! fibrous joint is_a: UBERON:0002213 {source="FMA"} ! cartilaginous joint property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/b/b1/Gray298.png" xsd:anyURI property_value: IAO:0000116 "consider adding fibrocartilage class" xsd:string property_value: skos:prefLabel "symphysis" xsd:string [Term] id: UBERON:0002217 name: synovial joint def: "Joint in which the articulating bones or cartilages are connected by an articular capsule which encloses a synovial membrane and a synovial cavity. Examples: Temporomandibular joint, knee joint.[FMA]." [FMA:7501, Wikipedia:Synovial_joint] subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "articulatio synoviale" EXACT [] synonym: "diarthrodial joints" RELATED OMO:0003004 [ZFA:0005153] synonym: "diarthroses" EXACT OMO:0003004 [ZFA:0005153] synonym: "diarthrosis" EXACT [] synonym: "diarthrosis joint" EXACT [] xref: AEO:0000183 xref: CALOHA:TS-2138 xref: EHDAA2:0003183 xref: FMA:7501 xref: galen:SynovialJoint xref: MA:0000322 xref: NCIT:C32461 xref: SCTID:113234001 xref: TAO:0005153 xref: Wikipedia:Synovial_joint xref: ZFA:0005153 is_a: UBERON:0000982 ! skeletal joint intersection_of: UBERON:0000982 ! skeletal joint intersection_of: RO:0002219 UBERON:0001484 ! surrounded by articular capsule disjoint_from: UBERON:0011134 ! nonsynovial joint relationship: RO:0002162 NCBITaxon:7742 ! in taxon Vertebrata relationship: RO:0002219 UBERON:0001484 ! surrounded by articular capsule property_value: skos:prefLabel "synovial joint" xsd:string [Term] id: UBERON:0002219 name: subfornical organ def: "Group of neurons situated on the ventral surface of the fornix at the level of the foramen of Monro in the third ventricle (adapted from Wikipedia via NIF)." [NLXANAT:100314, Wikipedia:Subfornical_organ] subset: uberon_slim synonym: "organum subfornicale" RELATED OMO:0003011 [Wikipedia:Subfornical_organ] xref: BAMS:SFO xref: DHBA:12104 xref: EMAPA:35830 xref: FMA:75260 xref: GAID:795 xref: MA:0000940 xref: MBA:338 xref: MESH:D013356 xref: neuronames:454 xref: NLXANAT:100314 xref: Wikipedia:Subfornical_organ is_a: UBERON:0010135 {source="MA"} ! sensory circumventricular organ relationship: BFO:0000050 UBERON:0002663 {source="MA-modified"} ! part of septal nuclear complex property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/d/d7/Gray715.png" xsd:anyURI property_value: skos:prefLabel "subfornical organ" xsd:string [Term] id: UBERON:0002222 name: perichondrium def: "Fibrous connective tissue that surrounds cartilage." [GO_REF:0000034, http://dx.plos.org/10.1371/journal.pone.0051070, https://github.com/obophenotype/uberon/issues/26, PSPUB:0000170, VSAO:0000036] subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "cartilage connective tissue" RELATED [] synonym: "perichondral region of cartilage" RELATED [] synonym: "perichondral region of cartilage element" RELATED [] xref: AAO:0010445 xref: BTO:0005089 xref: EMAPA:35676 xref: FMA:75446 xref: MA:0003008 xref: SCTID:11881003 xref: TAO:0001643 xref: VSAO:0000036 xref: Wikipedia:Perichondrium xref: XAO:0004049 xref: ZFA:0001634 is_a: UBERON:0002384 {source="VSAO"} ! connective tissue relationship: RO:0002007 UBERON:0007844 ! bounding layer of cartilage element property_value: terms:contributor https://orcid.org/0000-0002-6601-2165 property_value: terms:contributor https://orcid.org/0000-0003-3162-7490 [Term] id: UBERON:0002224 name: thoracic cavity def: "The part of the coelemic cavity lumen that is enclosed by the walls of the thorax." [UBERON:cjm, Wikipedia:Thoracic_cavity] subset: pheno_slim subset: uberon_slim synonym: "cavitas thoracis" EXACT OMO:0003011 [Wikipedia:Thoracic_cavity] synonym: "cavity of chest" EXACT [] synonym: "cavity of thorax" EXACT [] synonym: "chest cavity" EXACT [] synonym: "pectoral cavity" EXACT [] synonym: "space of thoracic compartment" EXACT [FMA:7565] synonym: "thoracic lumen" EXACT [] xref: EMAPA:36497 xref: FMA:7565 xref: GAID:93 xref: MA:0000032 xref: MESH:D035423 xref: NCIT:C12905 xref: SCTID:243949006 xref: UMLS:C0230139 {source="ncithesaurus:Thoracic_Cavity"} xref: Wikipedia:Thoracic_cavity is_a: UBERON:0000464 ! anatomical space intersection_of: UBERON:0000464 ! anatomical space intersection_of: BFO:0000050 UBERON:0002323 ! part of coelemic cavity lumen intersection_of: RO:0002572 UBERON:0000915 ! luminal space of thoracic segment of trunk relationship: BFO:0000050 UBERON:0002323 ! part of coelemic cavity lumen relationship: RO:0002572 UBERON:0000915 ! luminal space of thoracic segment of trunk property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/c/ce/Gray846.png" xsd:anyURI property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/e/ee/Scheme_body_cavities-en.svg" xsd:anyURI property_value: skos:prefLabel "thoracic cavity" xsd:string [Term] id: UBERON:0002227 name: spiral organ of cochlea def: "The organ of Corti (or spiral organ) is the organ in the inner ear of mammals that contains auditory sensory cells, or 'hair cells.' [WP,unvetted]." [Wikipedia:Organ_of_Corti] subset: efo_slim subset: pheno_slim subset: uberon_slim synonym: "auditory papilla" RELATED SENSU [ISBN:9780387714691] synonym: "auditory papillae" RELATED OMO:0003004 [ISBN:9780387714691] synonym: "basilar papilla" RELATED SENSU [XAO:0003145] synonym: "cochlear spiral organ" EXACT [] synonym: "Corti's organ" RELATED [BTO:0001691] synonym: "organ of Corti" RELATED [] synonym: "organum spirale" EXACT OMO:0003011 [Wikipedia:Organ_of_Corti] synonym: "papilla basilaris" RELATED SENSU [XAO:0003145] synonym: "spiral organ" EXACT [] synonym: "spiral organ of Corti" EXACT [] xref: BIRNLEX:2526 xref: BTO:0001691 xref: CALOHA:TS-0717 xref: EFO:0001364 xref: EMAPA:19061 xref: EV:0100364 xref: FMA:75715 xref: GAID:772 xref: MA:0001193 xref: NCIT:C33223 xref: ncithesaurus:Spiral_Organ_of_Corti xref: SCTID:279841009 xref: UMLS:C0029207 {source="BIRNLEX:2526", source="ncithesaurus:Organ_of_Corti"} xref: Wikipedia:Organ_of_Corti is_a: UBERON:0000020 ! sense organ relationship: BFO:0000050 UBERON:0001855 {source="MA"} ! part of cochlear duct of membranous labyrinth relationship: BFO:0000051 CL:0000202 ! has part auditory hair cell relationship: RO:0001025 UBERON:0002295 {source="Wikipedia:Scala_media"} ! located in scala media relationship: RO:0002162 NCBITaxon:32523 ! in taxon Tetrapoda relationship: RO:0002215 GO:0050910 ! capable of detection of mechanical stimulus involved in sensory perception of sound property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/c/c7/Cochlea-crosssection.png" xsd:anyURI property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/c/cb/Cochlea-crosssection.svg" xsd:anyURI property_value: RO:0002175 NCBITaxon:40674 [Term] id: UBERON:0002228 name: rib def: "An intersegmental rod-shaped bone that forms in the peritoneal membrane and attach to the vertebral parapophyses." [Wikipedia:Rib, ZFIN:curator] subset: efo_slim subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "dorsal rib" RELATED [] synonym: "pleural rib" RELATED [] synonym: "ribs" RELATED OMO:0003004 [TAO:0000538] xref: AAO:0000545 xref: CALOHA:TS-2209 xref: EFO:0003066 xref: EMAPA:18010 xref: FMA:7574 xref: GAID:245 xref: galen:Rib xref: MA:0000315 xref: MESH:D012272 xref: NCIT:C12782 xref: SCTID:302523002 xref: TAO:0000538 xref: UMLS:C0035561 {source="ncithesaurus:Rib"} xref: VHOG:0001154 xref: Wikipedia:Rib xref: ZFA:0000538 is_a: UBERON:0002513 ! endochondral bone is_a: UBERON:0015019 ! rib endochondral element intersection_of: UBERON:0015019 ! rib endochondral element intersection_of: RO:0002473 UBERON:0002481 ! composed primarily of bone tissue relationship: RO:0002202 UBERON:0006288 {evidence="definitional"} ! develops from rib cartilage element [Term] id: UBERON:0002234 name: proximal phalanx of manus def: "A proximal phalanx that is part of a finger [Automatically generated definition]." [OBOL:automatic] subset: pheno_slim synonym: "hand proximal phalanx" EXACT [MA:0001395] synonym: "phalanx proximalis manus" EXACT OMO:0003011 [FMA:75816, FMA:TA] synonym: "proximal manual phalanx" EXACT [] synonym: "proximal phalanx of finger" EXACT [FMA:75816] synonym: "proximal phalanx of fore digit" EXACT [] synonym: "proximal phalanx of hand" EXACT [] synonym: "proximal phalanx of manual digit" EXACT [] xref: EMAPA:37307 {source="MA:th"} xref: FMA:75816 xref: MA:0001395 xref: NCIT:C52786 xref: SCTID:181986000 xref: SCTID:361325003 xref: UMLS:C0730117 {source="ncithesaurus:Proximal_Phalanx_of_Hand"} is_a: UBERON:0001436 ! phalanx of manus is_a: UBERON:0004302 ! proximal phalanx intersection_of: UBERON:0004302 ! proximal phalanx intersection_of: BFO:0000050 UBERON:0002389 ! part of manual digit relationship: proximally_connected_to UBERON:0002374 ! metacarpal bone [Term] id: UBERON:0002237 name: true rib def: "A rib that is ventrally connected to the sternum." [ISBN:0073040584, Wikipedia:True_ribs] synonym: "costa vera" EXACT [] synonym: "costae verae" RELATED OMO:0003004 [Wikipedia:True_ribs] xref: EMAPA:37774 {source="MA:th"} xref: FMA:7592 xref: MA:0001419 xref: SCTID:368044009 xref: Wikipedia:True_ribs is_a: UBERON:0002228 ! rib intersection_of: UBERON:0002228 ! rib intersection_of: RO:0002170 UBERON:0000975 ! connected to sternum relationship: RO:0002170 UBERON:0000975 ! connected to sternum property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/3/3d/Gray115.png" xsd:anyURI [Term] id: UBERON:0002240 name: spinal cord def: "Part of the central nervous system located in the vertebral canal continuous with and caudal to the brain; demarcated from brain by plane of foramen magnum. It is composed of an inner core of gray matter in which nerve cells predominate, and an outer layer of white matter in which myelinated nerve fibers predominate, and surrounds the central canal. (CUMBO)." [BIRNLEX:1709] subset: cumbo subset: efo_slim subset: human_reference_atlas subset: major_organ subset: organ_slim subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "cerebro-cerebellar fissure" RELATED [NeuroNames:22] synonym: "cerebrocerebellar fissure" RELATED [NeuroNames:22] synonym: "fissura cerebro-cerebellaris" RELATED OMO:0003011 [NeuroNames:22] synonym: "fissura cerebrocerebellaris" RELATED OMO:0003011 [NeuroNames:22] synonym: "medulla spinalis" RELATED OMO:0003011 [BTO:0001279, Wikipedia:Spinal_cord] synonym: "SpC" RELATED OMO:0003000 [] synonym: "spinal cord structure" RELATED [ZFA:0000075] synonym: "spinal medulla" RELATED [BTO:0001279] xref: AAO:0010151 xref: BAMS:SP xref: BAMS:Spinal xref: BIRNLEX:1709 xref: BM:SpC xref: BTO:0001279 xref: CALOHA:TS-0953 xref: DHBA:12890 xref: DMBA:17651 xref: EFO:0000110 xref: EHDAA2:0001255 xref: EHDAA:2863 xref: EMAPA:17577 xref: EV:0100316 xref: FMA:7647 xref: GAID:695 xref: MA:0000216 xref: MAT:0000183 xref: MESH:D013116 xref: MIAA:0000183 xref: NCIT:C12464 xref: neuronames:22 {source="BIRNLEX:1709"} xref: SCTID:180959008 xref: TAO:0000075 xref: UMLS:C0037925 {source="ncithesaurus:Spinal_Cord", source="BIRNLEX:1709"} xref: VHOG:0000601 xref: Wikipedia:Spinal_cord xref: XAO:0000020 xref: ZFA:0000075 is_a: UBERON:0000489 ! cavitated compound organ is_a: UBERON:0004121 ! ectoderm-derived structure is_a: UBERON:0005174 ! dorsal region element is_a: UBERON:0010314 ! structure with developmental contribution from neural crest relationship: BFO:0000050 UBERON:0001017 ! part of central nervous system relationship: BFO:0000051 CL:0005000 {source="ZFA"} ! has part spinal cord interneuron relationship: RO:0002202 UBERON:0003076 ! develops from posterior neural tube relationship: RO:0002254 UBERON:0003853 {evidence="definitional"} ! has developmental contribution from spinal cord neural crest relationship: RO:0002495 UBERON:0006241 {evidence="definitional"} ! immediate transformation of future spinal cord property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/5/58/Spinal_cord_direv.svg" xsd:anyURI property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/spinal-cord-female/v1.1/assets/3d-vh-f-spinal-cord.glb" xsd:anyURI property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/spinal-cord-male/v1.1/assets/3d-vh-m-spinal-cord.glb" xsd:anyURI property_value: IAO:0000116 "TODO - add superclass to unify with VNC?" xsd:string property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "spinal cord" xsd:string [Term] id: UBERON:0002241 name: chondrocranium def: "Endoskeletal elements that encase the brain, nose, inner ear[cjm]. that part of the neurocranium formed by endochondral ossification and comprising the bones of the base of the skull[TFD]." [http://medical-dictionary.thefreedictionary.com/chondrocranium, Wikipedia:Chondrocranium] subset: vertebrate_core synonym: "calvarium" RELATED [MA:0000317] synonym: "neurocranium" RELATED INCONSISTENT [MA:0000317] xref: AAO:0010169 xref: EHDAA2:0000243 xref: EMAPA:17681 xref: TAO:0001424 xref: VHOG:0000288 xref: Wikipedia:Chondrocranium xref: ZFA:0001424 is_a: UBERON:0011159 ! primary subdivision of cranial skeletal system relationship: RO:0002131 UBERON:0001703 ! overlaps neurocranium property_value: IAO:0000116 "we follow the standard evolutionary classification and treat this as endoskeletal. This means what MA calls 'chondrocranium' must in fact be neurocranium, as it includes parts of the dermatocranium (e.g. frontal, parietal)" xsd:string property_value: skos:prefLabel "chondrocranium" xsd:string [Term] id: UBERON:0002242 name: nucleus pulposus def: "The jelly-like substance in the middle of the spinal disc which is a remnant of the notochord." [MGI:llw2, MP:0006392] comment: Function noyes: It functions to distribute hydraulic pressure in all directions within each disc under compressive loads. subset: pheno_slim subset: uberon_slim synonym: "nucleus propulsus" RELATED [Wikipedia:Nucleus_pulposus] synonym: "nucleus propulsus of intervertebral disk" RELATED [Wikipedia:Nucleus_pulposus] synonym: "nucleus pulposus (diskus intervertebralis)" EXACT [FMA:13550] synonym: "nucleus pulposus of intervertebral disk" RELATED [FMA:13550] synonym: "pulpy nucleus" EXACT [] xref: BTO:0003626 xref: EMAPA:18008 xref: FMA:13550 xref: FMA:76703 xref: MA:0000112 xref: SCTID:316586000 xref: Wikipedia:Nucleus_pulposus is_a: UBERON:0000062 ! organ is_a: UBERON:0002384 ! connective tissue is_a: UBERON:0004121 ! ectoderm-derived structure relationship: BFO:0000050 UBERON:0001066 ! part of intervertebral disk relationship: BFO:0000051 CHEBI:37397 ! has part relationship: BFO:0000051 CHEBI:60924 ! has part relationship: BFO:0000051 CL:0000138 ! has part chondrocyte relationship: BFO:0000051 UBERON:0011860 ! has part collection of collagen fibrils relationship: RO:0002202 UBERON:0002328 ! develops from notochord relationship: RO:0002433 UBERON:0001066 ! contributes to morphology of intervertebral disk property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/d/d9/Cervical_vertebra_english.png" xsd:anyURI [Term] id: UBERON:0002245 name: cerebellar hemisphere def: "A paired regions of the cerebellum that lie outside and lateral to the central vermis[MP]. The cerebellum consists of three parts, a median and two lateral, which are continuous with each other, and are substantially the same in structure. The median portion is constricted, and is called the vermis, from its annulated appearance which it owes to the transverse ridges and furrows upon it; the lateral expanded portions are named the hemispheres. The lateral hemisphere is considered the portion of the cerebellum to develop most recently. [WP,unvetted]." [MP:0009959, Wikipedia:Cerebellar_hemisphere] subset: pheno_slim subset: uberon_slim synonym: "cerebellar hemisphere" EXACT [] synonym: "cerebellar hemispheres" RELATED OMO:0003004 [] synonym: "cerebellum hemisphere" EXACT [] synonym: "hemisphere of cerebellum" EXACT [FMA:76925] synonym: "hemisphere of cerebellum [H II - H X]" EXACT [] synonym: "hemispherium cerebelli" RELATED OMO:0003011 [Wikipedia:Cerebellar_hemisphere] synonym: "hemispherium cerebelli [H II - H X]" EXACT OMO:0003011 [FMA:76925, FMA:TA] synonym: "hemispherium cerebelli [hII-hX]" EXACT OMO:0003011 [FMA:76925, FMA:TA] xref: BAMS:CH xref: BIRNLEX:1575 xref: DHBA:10659 xref: DMBA:16920 xref: EMAPA:35218 xref: FMA:76925 xref: HBA:12930 xref: MA:0000200 xref: MBA:1073 xref: NCIT:C32726 xref: neuronames:1214 xref: SCTID:362411002 xref: UMLS:C0228465 {source="ncithesaurus:Hemisphere_of_the_Cerebellum"} xref: Wikipedia:Cerebellar_hemisphere is_a: UBERON:0002749 ! regional part of cerebellar cortex is_a: UBERON:0015212 ! lateral structure relationship: BSPO:0000126 UBERON:0002037 ! cerebellum relationship: RO:0002433 UBERON:0002129 ! contributes to morphology of cerebellar cortex property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/4/43/CerebellumDiv.png" xsd:anyURI property_value: skos:prefLabel "cerebellar hemisphere" xsd:string [Term] id: UBERON:0002255 name: vomeronasal organ def: "An organ thought to supplement the olfactory system in receiving pheromonic communication. The sensory part of the organ is in two long, thin sacs, situated on either side of the nasal septum at its base." [VHOG:0000665] subset: efo_slim subset: organ_slim subset: pheno_slim subset: uberon_slim synonym: "Jacobson's organ" EXACT [XAO:0000272] synonym: "organ of Jacobsen" RELATED [] synonym: "organon vomeronasale" EXACT OMO:0003011 [] synonym: "organum vomeronasale" EXACT OMO:0003011 [Wikipedia:Vomeronasal_organ] synonym: "VNO" RELATED [VHOG:0000665] xref: AAO:0000997 xref: BTO:0002608 xref: EFO:0001934 xref: EHDAA2:0002211 xref: EHDAA:7865 xref: EMAPA:17612 xref: FMA:77280 xref: GAID:354 xref: MA:0000289 xref: MESH:D019147 xref: neuronames:1566 xref: SCTID:361346007 xref: VHOG:0000665 xref: Wikipedia:Vomeronasal_organ xref: XAO:0000272 is_a: UBERON:0000020 ! sense organ is_a: UBERON:0004121 ! ectoderm-derived structure relationship: BFO:0000050 UBERON:0000004 ! part of nose relationship: BFO:0000050 UBERON:0009954 ! part of vomeronasal system relationship: RO:0002202 UBERON:0003050 {source="Wikipedia"} ! develops from olfactory placode relationship: RO:0002215 GO:0043695 {source="Wikipedia"} ! capable of detection of pheromone relationship: RO:0002254 UBERON:0009714 {source="EHDAA2-abduced"} ! has developmental contribution from intermaxillary process property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/8/84/Gray51.png" xsd:anyURI property_value: skos:prefLabel "vomeronasal organ" xsd:string [Term] id: UBERON:0002256 name: dorsal horn of spinal cord def: "The pronounced, dorsolaterally oriented ridge of grey matter in each lateral half of the spinal cord[MP]. the dorsal (more towards the back) grey matter of the spinal cord. It receives several types of sensory information from the body, including light touch, proprioception, and vibration. This information is sent from receptors of the skin, bones, and joints through sensory neurons whose cell bodies lie in the dorsal root ganglion[WP]. The dorsal region of the mature spinal cord contains neurons that process and relay sensory input[GO]." [GO:0021516, https://sourceforge.net/tracker/?group_id=36855&atid=440764, MP:0006282, Wikipedia:Posterior_horn_of_spinal_cord] subset: pheno_slim subset: vertebrate_core synonym: "columna grisea posterior medullae spinalis" EXACT OMO:0003011 [FMA:256530, FMA:TA] synonym: "cornu dorsale" EXACT [ZFA:0000649] synonym: "cornu posterius medullae spinalis" EXACT OMO:0003011 [Wikipedia:Posterior_horn_of_spinal_cord] synonym: "dorsal gray column of spinal cord" EXACT [FMA:256530] synonym: "dorsal gray horn" EXACT [BIRNLEX:2667] synonym: "dorsal gray matter of spinal cord" EXACT [FMA:256530] synonym: "dorsal grey column of spinal cord" EXACT [] synonym: "dorsal grey horn" BROAD [EMAPA:18574] synonym: "dorsal horn" BROAD [ZFA:0000649] synonym: "dorsal horn of the spinal cord" RELATED [BAMS:DH] synonym: "dorsal horn spinal cord" EXACT [ZFA:0000649] synonym: "dorsal region of mature spinal cord" BROAD [] synonym: "dorsal region of spinal cord" BROAD [] synonym: "dorsal spinal cord" BROAD [] synonym: "posterior gray column of spinal cord" EXACT [FMA:256530] synonym: "posterior gray horn of spinal cord" EXACT [FMA:256530] synonym: "posterior grey column of spinal cord" EXACT [] synonym: "posterior horn of spinal cord" EXACT [Wikipedia:Posterior_horn_of_spinal_cord] synonym: "spinal cord dorsal horn" EXACT [] synonym: "spinal cord dorsal horns" RELATED OMO:0003004 [] synonym: "spinal cord posterior horn" EXACT [BIRNLEX:2667] xref: BAMS:DH xref: BIRNLEX:2667 xref: BM:SpC-DH xref: EMAPA:18574 xref: EMAPA:35790 xref: FMA:256530 xref: MA:0001119 xref: NCIT:C32473 xref: neuronames:1686 xref: SCTID:180961004 xref: TAO:0000649 xref: UMLS:C0228564 {source="BIRNLEX:2667"} xref: UMLS:C0228575 {source="ncithesaurus:Dorsal_Horn_of_the_Spinal_Cord"} xref: VHOG:0001287 xref: Wikipedia:Posterior_horn_of_spinal_cord xref: ZFA:0000649 is_a: UBERON:0015212 ! lateral structure is_a: UBERON:0016550 ! spinal cord column disjoint_from: UBERON:0002257 {source="lexical"} ! ventral horn of spinal cord relationship: BFO:0000051 CL:0000101 ! has part sensory neuron relationship: BSPO:0000126 UBERON:0002315 {source="FMA-abduced-lr"} ! gray matter of spinal cord relationship: RO:0002216 GO:0019230 {source="GO"} ! capable of part of proprioception relationship: RO:0002433 UBERON:0002315 ! contributes to morphology of gray matter of spinal cord property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/d/dc/Medulla_spinalis_-_Section_-_English.svg" xsd:anyURI [Term] id: UBERON:0002257 name: ventral horn of spinal cord def: "The ventral grey column of the spinal cord[MP]. The neurons of the ventral region of the mature spinal cord participate in motor output[GO]." [GO:0021517, https://sourceforge.net/tracker/?group_id=36855&atid=440764, MP:0005112, Wikipedia:Anterior_horn_of_spinal_cord] subset: pheno_slim subset: vertebrate_core synonym: "anterior column" RELATED [Wikipedia:Anterior_horn_of_spinal_cord] synonym: "anterior column of the spinal cord" RELATED [Wikipedia:Anterior_horn_of_spinal_cord] synonym: "anterior gray column of spinal cord" EXACT [FMA:256541] synonym: "anterior gray horn of spinal cord" EXACT [FMA:256541] synonym: "anterior grey column of spinal cord" EXACT [] synonym: "anterior horn" EXACT [BIRNLEX:2668] synonym: "anterior horn (spinal cord)" RELATED [Wikipedia:Anterior_horn_of_spinal_cord] synonym: "columna grisea anterior medullae spinalis" EXACT OMO:0003011 [FMA:256541, FMA:TA] synonym: "cornu anterius medullae spinalis" RELATED OMO:0003011 [Wikipedia:Anterior_horn_of_spinal_cord] synonym: "spinal cord anterior horn" EXACT [BIRNLEX:2668] synonym: "spinal cord ventral horn" EXACT [] synonym: "ventral gray column of spinal cord" EXACT [FMA:256541] synonym: "ventral gray matter of spinal cord" EXACT [FMA:256541] synonym: "ventral grey column of spinal cord" EXACT [] synonym: "ventral grey horn" EXACT [BIRNLEX:2668] synonym: "ventral horn of the spinal cord" RELATED [BAMS:VH] synonym: "ventral horn spinal cord" EXACT [ZFA:0000702] synonym: "ventral horns spinal cord" RELATED OMO:0003004 [VHOG:0001288] synonym: "ventral region of spinal cord" EXACT [] synonym: "ventral spinal cord" EXACT [] xref: BAMS:VH xref: BIRNLEX:2668 xref: BTO:0005151 xref: EMAPA:18575 xref: EMAPA:35794 xref: FMA:256541 xref: MA:0001134 xref: NCIT:C33859 xref: neuronames:1751 xref: SCTID:279443000 xref: TAO:0000702 xref: UMLS:C0228569 {source="BIRNLEX:2668"} xref: UMLS:C0228590 {source="ncithesaurus:Ventral_Horn_of_the_Spinal_Cord"} xref: VHOG:0001288 xref: Wikipedia:Anterior_horn_of_spinal_cord xref: ZFA:0000702 is_a: UBERON:0015212 ! lateral structure is_a: UBERON:0016550 ! spinal cord column relationship: BFO:0000051 CL:0000100 ! has part motor neuron relationship: BSPO:0000126 UBERON:0002315 {source="FMA-abduced-lr"} ! gray matter of spinal cord relationship: RO:0002433 UBERON:0002315 ! contributes to morphology of gray matter of spinal cord [Term] id: UBERON:0002261 name: dorsal root of spinal cord def: "The dorsal roots contain afferent sensory axons. The dorsal roots of each side continue outwards, along the way forming a dorsal root ganglion (also called a spinal ganglion)." [NLXANAT:20090208] subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "dorsal root" EXACT [ZFA:0000652] synonym: "dorsal root of spinal nerve" EXACT [FMA:5980] synonym: "dorsal roots" RELATED [BAMS:drt] synonym: "dorsal spinal nerve root" EXACT [FMA:5980] synonym: "dorsal spinal root" EXACT [] synonym: "posterior root of spinal nerve" EXACT [Wikipedia:Posterior_root_of_spinal_nerve] synonym: "radix dorsalis" EXACT [ZFA:0000652] synonym: "radix posterior" RELATED OMO:0003011 [Wikipedia:Posterior_root_of_spinal_nerve] synonym: "radix posterior (nervus spinalis)" EXACT [FMA:5980] synonym: "radix posterior nervi spinalis" RELATED [BTO:0000360] synonym: "radix sensoria (nervus spinalis)" EXACT [FMA:5980] synonym: "root dorsali nervi spinalis" RELATED [BTO:0000360] synonym: "root sensoria nervi spinalis" RELATED [BTO:0000360] synonym: "sensory root of spinal nerve" EXACT [FMA:5980] synonym: "sensory spinal root" RELATED [BTO:0000360] xref: BAMS:drt xref: BTO:0000360 xref: FMA:5980 xref: NCIT:C32477 xref: neuronames:1661 xref: NLXANAT:20090208 xref: SCTID:362436008 xref: TAO:0000652 xref: UMLS:C0205955 {source="ncithesaurus:Dorsal_Root_of_the_Spinal_Nerve"} xref: Wikipedia:Posterior_root_of_spinal_nerve xref: ZFA:0000652 is_a: UBERON:0009623 {source="FMA"} ! spinal nerve root relationship: extends_fibers_into UBERON:0000044 ! dorsal root ganglion relationship: RO:0002216 GO:0019230 {source="Wikipedia"} ! capable of part of proprioception property_value: foaf:depiction "https://upload.wikimedia.org/wikipedia/commons/d/d2/Spinal_nerve.svg" xsd:anyURI [Term] id: UBERON:0002262 name: celiac ganglion def: "The celiac ganglia are two large irregularly shaped masses of nerve tissue in the upper abdomen. Part of the sympathetic subdivision of the autonomic nervous system (ANS), the two celiac ganglia are the largest ganglia in the ANS, and they innervate most of the digestive tract. They have the appearance of lymph glands and are placed on either side of the midline in front of the crura of the diaphragm, close to the suprarenal glands (also called adrenal glands). The ganglion on the right side is placed behind the inferior vena cava. They are sometimes referred to as the semilunar ganglia or the solar ganglia. [WP,unvetted]." [Wikipedia:Celiac_ganglia] subset: human_reference_atlas subset: uberon_slim synonym: "coeliac ganglion" EXACT [FMA:77570] xref: BAMS:GCE xref: EHDAA2:0000266 xref: EHDAA:8946 xref: EMAPA:19321 xref: FMA:77570 xref: MA:0001158 xref: NCIT:C52830 xref: SCTID:362492008 xref: UMLS:C0007571 {source="ncithesaurus:Coeliac_Ganglion"} xref: Wikipedia:Celiac_ganglia is_a: UBERON:0003964 {source="MA"} ! prevertebral ganglion property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/6/63/Gray848.png" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0002263 name: lentiform nucleus def: "The lentiform nucleus or lenticular nucleus comprises the putamen and the globus pallidus within the basal ganglia. It is a large, cone-shaped mass of gray matter just lateral to the internal capsule. [WP,unvetted]." [Wikipedia:Lentiform_nucleus] subset: uberon_slim synonym: "lenticular nucleus" RELATED [BTO:0002250] synonym: "nucleus lenticularis" EXACT [BTO:0002250] synonym: "nucleus lentiformis" EXACT [BTO:0002250] synonym: "nucleus lentiformis" RELATED OMO:0003011 [Wikipedia:Lentiform_nucleus] xref: BTO:0002250 xref: EMAPA:18208 xref: EMAPA:19147 xref: EV:0100186 xref: FMA:77615 xref: MA:0000896 xref: NCIT:C32977 xref: neuronames:1234 xref: SCTID:279319002 xref: UMLS:C0162342 {source="ncithesaurus:Lenticular_Nucleus"} xref: Wikipedia:Lentiform_nucleus is_a: BFO:0000002 is_a: UBERON:0009663 ! telencephalic nucleus relationship: BFO:0000050 UBERON:0005403 {source="MA"} ! part of ventral striatum relationship: BFO:0000051 UBERON:0001874 ! has part putamen relationship: BFO:0000051 UBERON:0001875 ! has part globus pallidus property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/f/fc/Gray741.png" xsd:anyURI property_value: IAO:0000116 "TODO - add parts" xsd:string property_value: skos:prefLabel "lentiform nucleus" xsd:string [Term] id: UBERON:0002264 name: olfactory bulb def: "A bulbous anterior projection of the olfactory lobe that is the place of termination of the olfactory nerves and is especially well developed in lower vertebrates (as fishes)[BTO]." [BTO:0000961, Wikipedia:Olfactory_bulb] subset: human_reference_atlas subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "bulbus olfactorius" EXACT [Wikipedia:Olfactory_bulb] synonym: "bulbus olfactorius" RELATED OMO:0003011 [Wikipedia:Olfactory_bulb] synonym: "bulbus olfactorius (Morgagni)" RELATED OMO:0003011 [NeuroNames:279] synonym: "olfactory lobe" RELATED [ZFA:0000402] synonym: "olfactory lobe (Barr & Kiernan)" RELATED [NeuroNames:279] xref: AAO:0010165 xref: BAMS:DLB xref: BAMS:OB xref: BAMS:Olf xref: BIRNLEX:1137 xref: BM:Tel-OB xref: BTO:0000961 xref: CALOHA:TS-0702 xref: DHBA:10307 xref: EHDAA2:0004705 xref: EMAPA:32809 xref: EV:0100173 xref: FMA:77624 xref: GAID:633 xref: HBA:9303 xref: MA:0000194 xref: MESH:D009830 xref: NCIT:C28401 xref: neuronames:279 {source="BIRNLEX:1137"} xref: SCTID:279394006 xref: TAO:0000402 xref: UMLS:C0028936 {source="BIRNLEX:1137", source="ncithesaurus:Olfactory_Bulb"} xref: VHOG:0000033 xref: Wikipedia:Olfactory_bulb xref: XAO:0004180 xref: ZFA:0000402 is_a: UBERON:0002616 ! regional part of brain is_a: UBERON:0015212 ! lateral structure relationship: BFO:0000050 UBERON:0005366 ! part of olfactory lobe relationship: BFO:0000051 CL:0000626 {source="ZFA"} ! has part olfactory granule cell relationship: BSPO:0000126 UBERON:0001893 {source="ISBN:0471888893"} ! telencephalon relationship: RO:0002215 GO:0007608 ! capable of sensory perception of smell relationship: RO:0002433 UBERON:0005366 ! contributes to morphology of olfactory lobe property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/d/d2/1543%2CVesalius%27OlfactoryBulbs.jpg" xsd:anyURI property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/f/f9/1543,Vesalius%27OlfactoryBulbs.jpg" xsd:anyURI property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/brain-female/v1.4/assets/3d-allen-f-brain.glb" xsd:anyURI property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/brain-male/v1.4/assets/3d-allen-m-brain.glb" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "olfactory bulb" xsd:string [Term] id: UBERON:0002265 name: olfactory tract def: "White matter tract that contains projections from the olfactory bulb to other parts of the brain." [BIRNLEX:1663, http://orcid.org/0000-0002-6601-2165, ISBN:0471888893, Wikipedia:Olfactory_tract] subset: human_reference_atlas subset: pheno_slim subset: uberon_slim synonym: "olfactory peduncle" RELATED [BTO:0003647] synonym: "olfactory stalk" RELATED [NeuroNames:283] synonym: "pedunclulus olfactorius" RELATED OMO:0003011 [NeuroNames:283] synonym: "tractus olfactorium" RELATED OMO:0003011 [NeuroNames:283] synonym: "tractus olfactorius" RELATED OMO:0003011 [BTO:0003647, Wikipedia:Olfactory_tract] xref: BAMS:olf xref: BIRNLEX:1663 xref: BTO:0003647 xref: DHBA:12073 xref: EMAPA:35615 xref: FMA:77626 xref: HBA:9302 xref: MA:0000975 xref: NCIT:C33207 xref: neuronames:283 {source="BIRNLEX:1663"} xref: SCTID:362356008 xref: UMLS:C0162435 {source="ncithesaurus:Olfactory_Tract"} xref: Wikipedia:Olfactory_tract is_a: UBERON:0007702 ! tract of brain intersection_of: UBERON:0007702 ! tract of brain intersection_of: RO:0002131 UBERON:0002264 ! overlaps olfactory bulb relationship: BFO:0000050 UBERON:0011299 ! part of white matter of telencephalon relationship: RO:0002131 UBERON:0002264 ! overlaps olfactory bulb property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/4/4d/Gray732.png" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "olfactory tract" xsd:string [Term] id: UBERON:0002266 name: anterior olfactory nucleus def: "Laminated structure lying caudal to the olfactory bulb." [BIRNLEX:1085] subset: uberon_slim synonym: "anterior olfactory cortex" RELATED [BTO:0003649] synonym: "AON" RELATED [BTO:0003649] synonym: "area retrobulbaris" RELATED OMO:0003011 [NeuroNames:280] synonym: "nucleus olfactorius anterior" RELATED OMO:0003011 [Wikipedia:Anterior_olfactory_nucleus] synonym: "nucleus retrobulbaris [a8]" EXACT OMO:0003011 [FMA:77628, FMA:TA] synonym: "regio retrobulbaris" RELATED OMO:0003011 [NeuroNames:280] synonym: "retrobulbar nucleus [a8]" EXACT [] synonym: "retrobulbar region" RELATED [NeuroNames:280] xref: BAMS:AO xref: BAMS:AON xref: BIRNLEX:1085 xref: BM:Tel-OAN xref: BTO:0003649 xref: DHBA:10308 xref: EMAPA:35131 xref: EV:0100174 xref: FMA:77628 xref: HBA:4324 xref: MA:0000968 xref: MBA:159 xref: NCIT:C52710 xref: neuronames:280 {source="BIRNLEX:1085"} xref: UMLS:C0175225 {source="BIRNLEX:1085", source="ncithesaurus:Anterior_Olfactory_Nucleus"} xref: Wikipedia:Anterior_olfactory_nucleus is_a: UBERON:0009663 ! telencephalic nucleus relationship: BFO:0000050 UBERON:0002894 ! part of olfactory cortex property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/b/b1/Human_brainstem_anterior_view_2_description.JPG" xsd:anyURI property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/brain-female/v1.4/assets/3d-allen-f-brain.glb" xsd:anyURI property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/brain-male/v1.4/assets/3d-allen-m-brain.glb" xsd:anyURI property_value: skos:prefLabel "anterior olfactory nucleus" xsd:string [Term] id: UBERON:0002268 name: olfactory organ def: "An organ that houses olfactory neurons and is responsible for the sense of smell. Examples include the vertebrate nose and the Drosophila dorsal organ." [UBERON:cjm] subset: functional_classification synonym: "main olfactory organ" NARROW [] synonym: "olfactory neuroepithelium" RELATED [BTO:0001772] synonym: "olfactory organ" EXACT [BTO:0001772] synonym: "olfactory sense organ" EXACT [] synonym: "olfactory sensory organ" EXACT [FBbt:00005158] synonym: "organ olfactus" RELATED [BTO:0001772] synonym: "organum olfactorium" RELATED [BTO:0001772] synonym: "primary olfactory organ" NARROW [] xref: AAO:0010180 xref: BTO:0001772 xref: FBbt:00005158 {sssom:mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"} xref: FMA:77659 xref: VHOG:0000287 xref: XAO:0000273 is_a: UBERON:0000020 ! sense organ intersection_of: UBERON:0000020 ! sense organ intersection_of: RO:0002215 GO:0050911 ! capable of detection of chemical stimulus involved in sensory perception of smell relationship: BFO:0000051 CL:0000207 ! has part olfactory receptor cell relationship: RO:0002215 GO:0050911 ! capable of detection of chemical stimulus involved in sensory perception of smell property_value: IAO:0000116 "An olfactory organ overlaps with the olfactory system, because some parts of the nose (e.g. nasal skeleton) are parts of the skeletal system, which is spatially disjoint" xsd:string property_value: skos:prefLabel "olfactory organ" xsd:string [Term] id: UBERON:0002271 name: periventricular zone of hypothalamus synonym: "hypothalamus periventricular zone" EXACT [] synonym: "periventricular zone of the hypothalamus" RELATED [BAMS:PVZ] synonym: "zona periventricularis hypothalamicae" EXACT OMO:0003011 [FMA:77682, FMA:TA] xref: BAMS:PVZ xref: EMAPA:35421 xref: FMA:77682 xref: MA:0000846 xref: MBA:157 xref: neuronames:2292 xref: VHOG:0000623 is_a: UBERON:0000064 ! organ part relationship: BFO:0000050 UBERON:0001898 ! part of hypothalamus property_value: skos:prefLabel "periventricular zone of hypothalamus" xsd:string [Term] id: UBERON:0002272 name: medial zone of hypothalamus synonym: "hypothalamic medial zone behavioral control column" RELATED [BAMS:MEZ] synonym: "hypothalamus medial zone" EXACT [] synonym: "medial zone of the hypothalamus" RELATED [BAMS:MEZ, BAMS:MZ] synonym: "zona medialis hypothalamicae" EXACT OMO:0003011 [FMA:77683, FMA:TA] xref: BAMS:MEZ xref: BAMS:MZ xref: EMAPA:35419 xref: FMA:77683 xref: MA:0000837 xref: MBA:467 xref: neuronames:2291 is_a: UBERON:0000064 ! organ part disjoint_from: UBERON:0002273 {source="lexical"} ! lateral zone of hypothalamus relationship: BFO:0000050 UBERON:0001898 ! part of hypothalamus property_value: skos:prefLabel "medial zone of hypothalamus" xsd:string [Term] id: UBERON:0002273 name: lateral zone of hypothalamus synonym: "hypothalamic lateral zone" RELATED [BAMS:LZ] synonym: "hypothalamus lateral zone" EXACT [] synonym: "lateral zone of the hypothalamus" RELATED [BAMS:LZ] synonym: "zona lateralis hypothalamicae" EXACT OMO:0003011 [FMA:77684, FMA:TA] xref: BAMS:LZ xref: EMAPA:35418 xref: FMA:77684 xref: MA:0000833 xref: MBA:290 xref: neuronames:2290 is_a: UBERON:0000064 ! organ part relationship: BFO:0000050 UBERON:0001898 ! part of hypothalamus property_value: skos:prefLabel "lateral zone of hypothalamus" xsd:string [Term] id: UBERON:0002275 name: reticular formation def: "A composite substructure of the brainstem that consists of the midbrain reticular formation, the pontine reticular formation and the medullary reticular formation ( Carpenter-1983 )." [NeuroNames:1223] subset: uberon_slim synonym: "brain stem reticular formation" EXACT [NeuroNames:1223] synonym: "brainstem reticular formation" EXACT [MA:0003185, NeuroNames:1223] synonym: "reticular formation (classical)" EXACT [NeuroNames:1223] synonym: "reticular formation of the brainstem" EXACT [NeuroNames:1223] xref: BAMS:RET xref: EMAPA:35188 xref: FMA:77719 xref: MA:0003185 xref: MESH:D012154 xref: neuronames:1223 xref: NLX:143558 xref: SCTID:361552007 xref: Wikipedia:Reticular_formation is_a: UBERON:0002616 ! regional part of brain relationship: BFO:0000050 UBERON:0002298 ! part of brainstem property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/9/9b/Gray701.png" xsd:anyURI property_value: skos:prefLabel "reticular formation" xsd:string [Term] id: UBERON:0002276 name: lamina of spiral limbus def: "The osseous spiral lamina consists of two plates of bone, and between these are the canals for the transmission of the filaments of the acoustic nerve. On the upper plate of that part of the lamina which is outside the vestibular membrane, the periosteum is thickened to form the limbus spiralis (or limbus laminæ spiralis), this ends externally in a concavity, the sulcus spiralis internus, which represents, on section, the form of the letter C. [WP,unvetted]." [Wikipedia:Limbus_laminae_spiralis] subset: human_reference_atlas subset: pheno_slim subset: uberon_slim synonym: "limbus lamina spiralis" EXACT [MA:0001191] synonym: "limbus laminae spiralis" EXACT [FMA:77721] synonym: "limbus laminae spiralis osseae" EXACT [] synonym: "spiral limbus" RELATED [] synonym: "spiral limbus lamina" EXACT [FMA:77721] xref: EMAPA:35496 xref: FMA:77721 xref: MA:0001191 xref: Wikipedia:Limbus_laminae_spiralis is_a: UBERON:0000064 ! organ part relationship: BFO:0000050 UBERON:0001855 {source="MA"} ! part of cochlear duct of membranous labyrinth property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/a/a5/Gray930.png" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0002278 name: perilymphatic space def: "The fluid-filled space separating the membranous from the osseous labyrinth." [Dorlands_Medical_Dictionary:MerckSource] subset: vertebrate_core synonym: "cisterna perilymphatica" RELATED [http://medical-dictionary.thefreedictionary.com/perilymphatic+space] synonym: "Retzius space" RELATED [] synonym: "spatium perilymphaticum" RELATED [http://medical-dictionary.thefreedictionary.com/perilymphatic+space] xref: BTO:0002083 xref: FMA:77745 xref: SCTID:362576001 xref: Wikipedia:Perilymphatic_space xref: ZFA:0005459 is_a: UBERON:0002553 ! anatomical cavity relationship: BFO:0000050 UBERON:0001846 {source="ZFA"} ! part of internal ear relationship: RO:0002220 UBERON:0001839 ! adjacent to bony labyrinth relationship: RO:0002220 UBERON:0001849 ! adjacent to membranous labyrinth [Term] id: UBERON:0002282 name: stria vascularis of cochlear duct def: "The upper portion of the spiral ligament contains numerous capillary loops and small blood vessels, and is termed the stria vascularis. It produces endolymph for the scala media, one of the three fluid-filled compartments of the cochlea. [WP,unvetted]." [Wikipedia:Stria_vascularis] subset: efo_slim subset: pheno_slim subset: uberon_slim synonym: "psalterial cord" EXACT [MP:0000048] synonym: "stria vascularis" EXACT [] synonym: "stria vascularis ductus cochlearis" RELATED OMO:0003011 [BTO:0001819] synonym: "stria vascularis of cochlea" EXACT [FMA:77832] synonym: "vascular stria of cochlear duct" RELATED [BTO:0001819] synonym: "vascular stripe of cochlear duct" EXACT [MP:0000048] xref: BIRNLEX:2525 xref: BTO:0001819 xref: CALOHA:TS-0982 xref: EFO:0001644 xref: EMAPA:35827 xref: FMA:77832 xref: GAID:875 xref: MA:0001198 xref: MESH:D013316 xref: SCTID:279842002 xref: UMLS:C0229477 {source="BIRNLEX:2525"} xref: Wikipedia:Stria_vascularis is_a: UBERON:0000064 ! organ part is_a: UBERON:0010314 ! structure with developmental contribution from neural crest relationship: BFO:0000050 UBERON:0001855 {source="FMA", source="MA"} ! part of cochlear duct of membranous labyrinth property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/c/c7/Cochlea-crosssection.png" xsd:anyURI [Term] id: UBERON:0002283 name: nail matrix def: "Portion of tissue (or germinal matrix) upon which the nail rests, the part of the nail bed that extends beneath the nail root and contains nerves, lymph and blood vessels. The matrix is responsible for the production of the cells that become the nail plate. The width and thickness of the nail plate is determined by the size, length, and thickness of the matrix, while the shape of the fingertip itself determines if the nail plate is flat, arched, or hooked. The matrix will continue to grow as long as it receives nutrition and remains in a healthy condition. As new nail plate cells are incubated, they emerge from the matrix round and white to push older nail plate cells forward; and in this way yet older cells become compressed, flat, and translucent, making the pink colour of the capillaries in the nail bed below visible[WP]." [https://orcid.org/0000-0002-6601-2165] subset: uberon_slim synonym: "keratogenous membrane" EXACT [Wikipedia:Nail_(anatomy)#Parts_of_the_nail] synonym: "matrix unguis" EXACT OMO:0003011 [Wikipedia:Nail_(anatomy)#Parts_of_the_nail] synonym: "nail germinal matrix" EXACT [Wikipedia:Nail_(anatomy)#Parts_of_the_nail] synonym: "nail root" RELATED [http://dermatology.about.com/cs/nailanatomy/a/nailanatomy.htm] synonym: "onychostroma" EXACT [Wikipedia:Nail_(anatomy)#Parts_of_the_nail] xref: EMAPA:35582 xref: FMA:77856 xref: MA:0002707 is_a: UBERON:0000479 ! tissue relationship: BFO:0000050 UBERON:0001705 ! part of nail relationship: site_of GO:0008283 ! cell population proliferation [Term] id: UBERON:0002285 name: telencephalic ventricle def: "A brain ventricle that is part of a telencephalon. In mammals and species with an evaginated telencephalon, this is one of a pair of lateral structures, one in each hemisphere." [https://orcid.org/0000-0002-6601-2165, Wikipedia:Lateral_ventricle] comment: modeled as space in EHDAA2 subset: efo_slim subset: human_reference_atlas subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "forebrain ventricle" RELATED [] synonym: "lateral ventricle" EXACT HUMAN_PREFERRED [MA:0000192] synonym: "lateral ventricle of brain" RELATED [BTO:0000879] synonym: "lateral ventricles" EXACT OMO:0003004 [] synonym: "tectal ventricle" RELATED [] synonym: "telencephalic ventricle" EXACT [VHOG:0000643, ZFA:0000696] synonym: "telencephalic ventricles" RELATED [BAMS:Tel-V] synonym: "telencephalic vesicle" RELATED [ZFA:0000696] synonym: "telencephalon lateral ventricle" EXACT [EHDAA2:0001984] xref: BAMS:LV xref: BAMS:Tel-V xref: BIRNLEX:1263 xref: BM:Tel-LV xref: BTO:0000879 xref: CALOHA:TS-1230 xref: DHBA:10596 xref: DMBA:126651562 xref: EFO:0001961 xref: EHDAA2:0001984 xref: EHDAA:3502 xref: EHDAA:6576 xref: EV:0100307 xref: FMA:78448 xref: GAID:611 xref: HBA:9419 xref: MA:0000192 xref: MBA:81 xref: MESH:D020547 xref: NCIT:C12834 xref: neuronames:209 xref: SCTID:180930008 xref: TAO:0000696 xref: UMLS:C0152279 {source="ncithesaurus:Lateral_Ventricle", source="BIRNLEX:1263"} xref: VHOG:0000643 xref: Wikipedia:Lateral_ventricle xref: ZFA:0000696 is_a: BFO:0000002 is_a: UBERON:0004086 ! brain ventricle intersection_of: UBERON:0004086 ! brain ventricle intersection_of: BFO:0000050 UBERON:0001893 ! part of telencephalon relationship: BFO:0000050 UBERON:0001893 ! part of telencephalon relationship: RO:0002494 UBERON:0009676 ! transformation of early telencephalic vesicle property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/7/7d/Gray734.png" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "telencephalic ventricle" xsd:string [Term] id: UBERON:0002286 name: third ventricle def: "Part of the ventricular system of the brain, forming a single large cavity in the midline of the diencephalon; it is continuous with the lateral ventricles through the interventricular foramen and the fourth ventricle through the cerebral aqueduct. (Maryann Martone)." [BIRNLEX:714] subset: human_reference_atlas subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "3rd ventricle" EXACT [] synonym: "diencephalic ventricle" RELATED [] synonym: "diencephalic vesicle" NARROW [] synonym: "ventriculus diencephali" EXACT [ZFA:0000161] synonym: "ventriculus tertius cerebri" RELATED OMO:0003011 [Wikipedia:Third_ventricle] xref: BAMS:3V xref: BAMS:V3 xref: BIRNLEX:714 xref: BM:Die-3V xref: CALOHA:TS-2058 xref: DHBA:10602 xref: EHDAA2:0000084 xref: EMAPA:16900 xref: EV:0100308 xref: FMA:78454 xref: GAID:614 xref: HBA:9420 xref: MA:0000182 xref: MBA:129 xref: MESH:D020542 xref: NCIT:C12827 xref: neuronames:446 xref: SCTID:180931007 xref: TAO:0000161 xref: UMLS:C0149555 {source="ncithesaurus:Third_Ventricle_of_Brain", source="BIRNLEX:714"} xref: VHOG:0000007 xref: Wikipedia:Third_ventricle xref: ZFA:0000161 is_a: BFO:0000002 is_a: UBERON:0004086 ! brain ventricle relationship: BFO:0000050 UBERON:0001894 ! part of diencephalon relationship: RO:0002202 UBERON:0006284 {source="EHDAA2"} ! develops from early prosencephalic vesicle relationship: RO:0002433 UBERON:0001894 ! contributes to morphology of diencephalon property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/7/7d/Gray734.png" xsd:anyURI property_value: IAO:0000116 "consider adding class for secondary vesicle precursor" xsd:string property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "third ventricle" xsd:string [Term] id: UBERON:0002288 name: choroid plexus of third ventricle def: "Part of choroid plexus contained in the third ventricle." [NLX:18606] subset: vertebrate_core synonym: "3rd ventricle choroid plexus" RELATED [] synonym: "chorioid plexus of cerebral hemisphere of third ventricle" EXACT [OBOL:automatic] synonym: "chorioid plexus of third ventricle" EXACT [] synonym: "choroid plexus third ventricle" EXACT [ZFA:0001444] synonym: "diencephalic choroid plexus" EXACT [ZFA:0001444] synonym: "third ventricle chorioid plexus of cerebral hemisphere" EXACT [OBOL:automatic] synonym: "third ventricle choroid plexus" EXACT [] xref: BAMS:chp3 xref: BAMS:cp3v xref: EMAPA:18543 xref: FMA:78462 xref: HBA:9709 xref: MA:0000879 xref: NCIT:C49782 xref: neuronames:452 xref: NLX:18606 xref: SCTID:61576002 xref: TAO:0001444 xref: UMLS:C0152291 {source="ncithesaurus:Choroid_Plexus_of_the_Third_Ventricle"} xref: VHOG:0001374 xref: ZFA:0001444 is_a: UBERON:0001886 ! choroid plexus intersection_of: UBERON:0001886 ! choroid plexus intersection_of: BFO:0000050 UBERON:0002286 ! part of third ventricle relationship: BFO:0000050 UBERON:0002286 ! part of third ventricle property_value: skos:prefLabel "choroid plexus of third ventricle" xsd:string [Term] id: UBERON:0002290 name: choroid plexus of fourth ventricle def: "Choroid plexus of the fourth ventricle." [NLX:27388] subset: vertebrate_core synonym: "4th ventricle choroid plexus" RELATED [] synonym: "chorioid plexus of cerebral hemisphere of fourth ventricle" EXACT [OBOL:automatic] synonym: "chorioid plexus of fourth ventricle" EXACT [] synonym: "choroid plexus fourth ventricle" EXACT [ZFA:0001446] synonym: "fourth ventricle chorioid plexus of cerebral hemisphere" EXACT [OBOL:automatic] synonym: "fourth ventricle choroid plexus" EXACT [] xref: BAMS:chp4 xref: BAMS:cp4v xref: DHBA:12808 xref: EMAPA:32742 xref: FMA:78492 xref: HBA:9710 xref: MA:0000983 xref: NCIT:C32308 xref: neuronames:638 xref: NLX:27388 xref: SCTID:42214001 xref: TAO:0001446 xref: UMLS:C0152293 {source="ncithesaurus:Choroid_Plexus_of_the_Fourth_Ventricle"} xref: VHOG:0001375 xref: ZFA:0001446 is_a: UBERON:0001886 ! choroid plexus is_a: UBERON:0006694 ! cerebellum vasculature intersection_of: UBERON:0001886 ! choroid plexus intersection_of: BFO:0000050 UBERON:0002422 ! part of fourth ventricle relationship: BFO:0000050 UBERON:0002422 ! part of fourth ventricle property_value: skos:prefLabel "choroid plexus of fourth ventricle" xsd:string [Term] id: UBERON:0002291 name: central canal of spinal cord def: "Spinal cord structure that is part of the ventricular system and is filled with cerebral-spinal fluid and runs the length of the spinal cord." [PMID:23409159, ZFIN:curator] comment: previously mapped to FMA:75364. Note some ontologies (NIF, SNOMED) subdivide this into lumbar, thoracic, etc. Note we follow FMA in distinguishing between the canal and the lumen subset: human_reference_atlas subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "canalis centralis" EXACT [ZFA:0000938] synonym: "central canal" EXACT [ZFA:0000938] synonym: "central canal of spinal cord" EXACT [] synonym: "central canal, spinal cord/medulla" RELATED [BAMS:C] synonym: "spinal cord central canal" EXACT [] synonym: "ventricle of spinal cord" EXACT [FMA:78497] xref: BAMS:C xref: BAMS:CC xref: BIRNLEX:1409 xref: DHBA:146035108 xref: DMBA:126652042 xref: EHDAA2:0004361 xref: EMAPA:35789 xref: FMA:78497 xref: HBA:9422 xref: MA:0001117 xref: MBA:164 xref: NCIT:C12891 xref: neuronames:1733 xref: SCTID:279447004 xref: TAO:0000938 xref: UMLS:C0459414 {source="ncithesaurus:Central_Canal"} xref: Wikipedia:Central_canal_of_spinal_cord xref: ZFA:0000938 is_a: UBERON:0004111 {source="cjm"} ! anatomical conduit is_a: UBERON:0004121 ! ectoderm-derived structure relationship: BFO:0000050 UBERON:0002240 {source="MA"} ! part of spinal cord relationship: BFO:0000050 UBERON:0005281 {source="FMA"} ! part of ventricular system of central nervous system relationship: BFO:0000051 UBERON:0001359 ! has part cerebrospinal fluid relationship: channel_for UBERON:0001359 ! cerebrospinal fluid relationship: RO:0002202 UBERON:0001049 ! develops from neural tube relationship: RO:0002433 UBERON:0002240 ! contributes to morphology of spinal cord property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/d/dc/Medulla_spinalis_-_Section_-_English.svg" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "central canal of spinal cord" xsd:string [Term] id: UBERON:0002294 name: biliary system def: "Organ system subdivision that consists of the organs and ducts that are involved in the production and transportation of bile. In most species this is the gallbladder and the bile ducts (biliary tree)." [Wikipedia:Biliary_system] subset: pheno_slim subset: uberon_slim synonym: "biliary apparatus" EXACT [FMA:79646] synonym: "biliary tract" RELATED [FMA:79646, MA:0001273] xref: FMA:79646 xref: GAID:279 xref: MA:0001273 xref: MESH:D001659 xref: NCIT:C12678 xref: SCTID:361354009 xref: Wikipedia:Biliary_system is_a: BFO:0000002 is_a: UBERON:0011216 ! organ system subdivision intersection_of: UBERON:0011216 ! organ system subdivision intersection_of: BFO:0000051 UBERON:0001173 ! has part biliary tree intersection_of: RO:0002215 GO:0006699 ! capable of bile acid biosynthetic process intersection_of: RO:0002215 GO:0015721 ! capable of bile acid and bile salt transport disjoint_from: UBERON:0002330 ! exocrine system disjoint_from: UBERON:0002390 ! hematopoietic system disjoint_from: UBERON:0002405 ! immune system disjoint_from: UBERON:0002416 ! integumental system disjoint_from: UBERON:0002423 ! hepatobiliary system disjoint_from: UBERON:0004456 ! entire sense organ system disjoint_from: UBERON:8450002 ! excretory system relationship: BFO:0000050 UBERON:0002423 ! part of hepatobiliary system relationship: BFO:0000051 UBERON:0001173 ! has part biliary tree relationship: RO:0002215 GO:0006699 ! capable of bile acid biosynthetic process relationship: RO:0002215 GO:0015721 ! capable of bile acid and bile salt transport property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/5/5d/Digestive_system_showing_bile_duct.png" xsd:anyURI property_value: skos:prefLabel "biliary system" xsd:string [Term] id: UBERON:0002295 name: scala media def: "The division of the spiral canal of the cochlea that contains the organ of Corti (the neuroepithelial receptor organ for hearing)." [MGI:anna, MP:0003169, PMID:1680563] comment: located in between the scala tympani and the scala vestibuli, separated by the basilar membrane and Reissner's membrane (the vestibular membrane) respectively. Scala media houses the organ of Corti. [Wikipedia:Scala_media] subset: pheno_slim subset: uberon_slim synonym: "cochlear duct" RELATED [] xref: EMAPA:35751 xref: FMA:79789 xref: MA:0002458 xref: MESH:D003053 {sssom:mapping_justification="https://w3id.org/semapv/vocab/LexicalMatching"} xref: Wikipedia:Scala_media is_a: UBERON:0011060 {source="MA"} ! perilymphatic channel is_a: UBERON:0013685 ! foramen of skull relationship: BFO:0000050 UBERON:0001844 {source="FMA"} ! part of cochlea relationship: RO:0002433 UBERON:0001844 ! contributes to morphology of cochlea property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/b/bc/Gray928.png" xsd:anyURI property_value: IAO:0000116 "TODO - check cochlear duct vs cochlear aqueduct vs scala media" xsd:string [Term] id: UBERON:0002298 name: brainstem def: "Stalk-like part of the brain that includes amongst its parts the medulla oblongata of the hindbrain and the tegmentum of the midbrain[ZFA,MP,generalized]." [ISBN:0471888893, MP:0005277, Wikipedia:Brainstem, ZFA:0001707] comment: 'brainstem' is a loose term that sometimes refers to the ventral parts o the brain except for any part of the telencephalon - sometimes it includes the diencephalon or subpallial telencephalon structures (ISBN:0471888893). Here we use it in a more restriced sense, to include only the medulla oblongata, pons (when present) and the midbrain tegmentum (following the ZFA definitions). subset: efo_slim subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "accessory medullary lamina of pallidum" RELATED [NeuroNames:236] synonym: "brain stem" EXACT [ABA:BS] synonym: "lamella pallidi incompleta" RELATED OMO:0003011 [NeuroNames:236] synonym: "lamina medullaris accessoria" RELATED OMO:0003011 [NeuroNames:236] synonym: "lamina medullaris incompleta pallidi" RELATED OMO:0003011 [NeuroNames:236] synonym: "lamina pallidi incompleta" RELATED OMO:0003011 [NeuroNames:236] synonym: "truncus encephali" EXACT OMO:0003011 [Wikipedia:Brainstem] synonym: "truncus encephalicus" RELATED OMO:0003011 [BTO:0000146] xref: BAMS:BS xref: BIRNLEX:1565 xref: BTO:0000146 xref: CALOHA:TS-0093 xref: EFO:0001962 xref: EMAPA:32678 xref: EV:0100241 xref: FMA:79876 xref: MA:0000169 xref: MBA:343 xref: MESH:D001933 xref: NCIT:C12441 xref: neuronames:236 {source="BIRNLEX:1565"} xref: SCTID:180925009 xref: TAO:0002156 xref: UMLS:C0006121 {source="BIRNLEX:1565", source="ncithesaurus:Brain_Stem"} xref: VHOG:0001457 xref: Wikipedia:Brainstem xref: ZFA:0001707 is_a: UBERON:0002616 ! regional part of brain relationship: BFO:0000051 UBERON:0001896 ! has part medulla oblongata relationship: BFO:0000051 UBERON:0001943 ! has part midbrain tegmentum relationship: RO:0002150 UBERON:0002240 ! continuous with spinal cord relationship: RO:0002433 UBERON:0000955 ! contributes to morphology of brain property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/b/b7/Gray719.png" xsd:anyURI property_value: skos:prefLabel "brainstem" xsd:string [Term] id: UBERON:0002299 name: alveolus of lung def: "Spherical outcropping of the respiratory bronchioles and primary site of gas exchange with the blood. Alveoli are particular to mammalian lungs. Different structures are involved in gas exchange in other vertebrates[WP]." [Wikipedia:Pulmonary_alveolus] subset: efo_slim subset: human_reference_atlas subset: pheno_slim subset: uberon_slim synonym: "alveoli" RELATED OMO:0003004 [BTO:0000060] synonym: "alveolus" BROAD [] synonym: "alveolus pulmonis" EXACT [Wikipedia:Pulmonary_alveolus] synonym: "alveolus pulmonis" RELATED OMO:0003011 [Wikipedia:Pulmonary_alveolus] synonym: "lung alveolus" EXACT [] synonym: "pulmonary alveolus" EXACT [FMA:7318] synonym: "respiratory alveoli" RELATED OMO:0003004 [] synonym: "respiratory alveolus" EXACT [] xref: BTO:0000060 xref: CALOHA:TS-0031 xref: EFO:0001985 xref: EMAPA:32682 xref: FMA:7318 xref: GAID:349 xref: MA:0000420 xref: MESH:D011650 xref: SCTID:361364000 xref: VHOG:0001445 xref: Wikipedia:Pulmonary_alveolus is_a: UBERON:0003215 ! alveolus intersection_of: UBERON:0003215 ! alveolus intersection_of: BFO:0000050 UBERON:0002048 ! part of lung relationship: BFO:0000050 UBERON:0006524 {source="MA"} ! part of alveolar system relationship: BFO:0000050 UBERON:0008874 ! part of pulmonary acinus relationship: BFO:0000067 GO:0007585 ! contains process respiratory gaseous exchange by respiratory system relationship: RO:0002162 NCBITaxon:40674 {source="PMID:12625309", source="PMID:12869615"} ! in taxon Mammalia relationship: RO:0002433 UBERON:0008874 ! contributes to morphology of pulmonary acinus property_value: foaf:depiction "https://upload.wikimedia.org/wikipedia/commons/4/46/Alveolus_diagram.svg" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0002301 name: layer of neocortex def: "One of the layers of the neocortex. These layers are defined by distinctive populations of cells based on somata size, shape, or density, that are aligned into sheets." [http://orcid.org/0000-0002-6601-2165, ISBN-10:0-87893-742-0, PMID:29081739] synonym: "cerebral cortex layer" RELATED [MA:0000186] synonym: "cortical layer" BROAD [] synonym: "lamina of neocortex" RELATED [FMA:83138] synonym: "layer of neocortex" EXACT [FMA:83138] synonym: "neocortex layer" EXACT [MA:0000186] xref: ABA:CTX1-6b xref: EMAPA:35588 xref: FMA:83138 xref: MA:0000186 is_a: UBERON:0022303 ! nervous system cell part layer is_a: UBERON:8440004 ! laminar subdivision of the cortex intersection_of: UBERON:0022303 ! nervous system cell part layer intersection_of: BFO:0000050 UBERON:0001950 ! part of neocortex property_value: skos:prefLabel "layer of neocortex" xsd:string [Term] id: UBERON:0002302 name: myocardium of atrium def: "The atrial part of middle layer of the heart, comprised of involuntary muscle." [ISBN:0-683-40008-8, MP:0010493] subset: efo_slim subset: pheno_slim subset: vertebrate_core synonym: "atrial myocardium" EXACT [ZFA:0001374] synonym: "atrium cardiac muscle" RELATED [VHOG:0000602] synonym: "atrium myocardium" EXACT [] xref: EFO:0003087 xref: EMAPA:32746 xref: FMA:83509 xref: MA:0000081 xref: SCTID:191910002 xref: TAO:0001374 xref: VHOG:0000602 xref: ZFA:0001374 is_a: UBERON:0002349 ! myocardium intersection_of: UBERON:0002349 ! myocardium intersection_of: BFO:0000050 UBERON:0002081 ! part of cardiac atrium relationship: BFO:0000050 UBERON:0002081 ! part of cardiac atrium relationship: RO:0002433 UBERON:0002081 ! contributes to morphology of cardiac atrium property_value: skos:prefLabel "myocardium of atrium" xsd:string [Term] id: UBERON:0002303 name: juxtaglomerular apparatus def: "An anatomical structure which consists of juxtaglomerular cells, extraglomerular mesangial cells and the macula densa. The juxtaglomerular apparatus lies adjacent to the glomerulus and regulates kidney function by maintaining the blood flow to the kidney and the filtration rate[GO]. a microscopic structure in the kidney, which regulates the function of each nephron. The juxtaglomerular apparatus is named for its proximity to the glomerulus: it is found between the vascular pole of the renal corpuscle and the returning distal convoluted tubule of the same nephron. This location is critical to its function in regulating renal blood flow and glomerular filtration rate. The three cellular components of the apparatus are the macula densa, extraglomerular mesangial cells, and juxtaglomerular cells (also known as granular cells)[WP]." [GO:0072206, Wikipedia:Juxtaglomerular_apparatus] subset: human_reference_atlas subset: pheno_slim subset: uberon_slim synonym: "complexus juxtaglomerularis" EXACT OMO:0003011 [] synonym: "juxtaglomerular complex" EXACT [MP:0002829] xref: BTO:0005157 xref: EMAPA:30449 xref: FMA:83599 xref: GAID:432 xref: MA:0002546 xref: MESH:D007606 xref: NCIT:C32891 xref: SCTID:362219002 xref: UMLS:C0022445 {source="ncithesaurus:Juxtaglomerular_Apparatus"} xref: Wikipedia:Juxtaglomerular_apparatus is_a: BFO:0000002 is_a: UBERON:0000061 ! anatomical structure relationship: BFO:0000050 UBERON:0001225 {source="MA"} ! part of cortex of kidney relationship: BFO:0000051 CL:0000648 ! has part kidney granular cell relationship: BFO:0000051 CL:0002173 ! has part extraglomerular mesangial cell relationship: BFO:0000051 UBERON:0002335 ! has part macula densa relationship: RO:0002215 GO:0003093 {source="GO"} ! capable of regulation of glomerular filtration property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0002304 name: layer of dentate gyrus def: "One of the three layers of the dentate gyrus of the hippocampal formation." [http://orcid.org/0000-0002-6601-2165, PMCID:PMC2492885] synonym: "dentate gyrus cell layer" EXACT [] synonym: "dentate gyrus layer" EXACT [] xref: EMAPA:35278 xref: FMA:83678 xref: MA:0002429 is_a: UBERON:0011215 ! central nervous system cell part cluster is_a: UBERON:0022303 ! nervous system cell part layer intersection_of: UBERON:0022303 ! nervous system cell part layer intersection_of: BFO:0000050 UBERON:0001885 ! part of dentate gyrus of hippocampal formation relationship: BFO:0000050 UBERON:0001885 ! part of dentate gyrus of hippocampal formation property_value: skos:prefLabel "layer of dentate gyrus" xsd:string [Term] id: UBERON:0002305 name: layer of hippocampus def: "The layers of the laminar structure of the hippocampus." [MP:0000813, Wikipedia:Hippocampus_anatomy#Hippocampal_Cells_and_Layers] comment: EDITOR_NOTE TODO - check NIF xref subset: pheno_slim synonym: "cytoarchitectural fields of hippocampal formation" EXACT [BIRNLEX:1192] synonym: "hippocampus layer" EXACT [] synonym: "hippocampus proper layer" RELATED [FMA:83679] synonym: "layer of cornu ammonis" RELATED [FMA:83679] xref: BIRNLEX:1192 xref: EMAPA:35407 xref: FMA:277842 xref: FMA:83679 xref: MA:0002427 xref: Wikipedia:Hippocampus_anatomy#Hippocampal_Cells_and_Layers is_a: UBERON:0011215 ! central nervous system cell part cluster is_a: UBERON:0016548 ! central nervous system gray matter layer intersection_of: UBERON:0016548 ! central nervous system gray matter layer intersection_of: BFO:0000050 UBERON:0002421 ! part of hippocampal formation relationship: BFO:0000050 UBERON:0002421 ! part of hippocampal formation relationship: RO:0002433 UBERON:0002421 ! contributes to morphology of hippocampal formation property_value: skos:prefLabel "layer of hippocampus" xsd:string [Term] id: UBERON:0002306 name: nasal mucus def: "Mucus produced in the nasal cavity, by the respiratory segment of the nasal mucosa." [http://orcid.org/0000-0002-6601-2165] comment: EDITOR_NOTE TODO - split nasal vs respiratory tract? subset: uberon_slim synonym: "respiratory mucus" RELATED [BTO:0003603] xref: BTO:0003603 xref: CALOHA:TS-0658 xref: EMAPA:36552 xref: FMA:83688 xref: MA:0002535 xref: NCIT:C52551 xref: UMLS:C0225392 {source="ncithesaurus:Nasal_Mucus"} xref: Wikipedia:Nasal_mucus#Respiratory_system is_a: UBERON:0016553 ! respiratory system mucus intersection_of: UBERON:0000912 ! mucus intersection_of: RO:0003001 UBERON:0015786 ! produced by respiratory segment of nasal mucosa relationship: RO:0003001 UBERON:0015786 ! produced by respiratory segment of nasal mucosa [Term] id: UBERON:0002307 name: choroid plexus of lateral ventricle def: "Part of choroid plexus contained in the lateral ventricle." [NLX:32548] subset: vertebrate_core synonym: "chorioid plexus of cerebral hemisphere of lateral ventricle" EXACT [OBOL:automatic] synonym: "chorioid plexus of lateral ventricle" EXACT [] synonym: "choroid plexus telencephalic ventricle" EXACT [ZFA:0001447] synonym: "lateral ventricle chorioid plexus of cerebral hemisphere" EXACT [OBOL:automatic] synonym: "lateral ventricle choroid plexus" EXACT [] xref: BAMS:cplv xref: DHBA:10601 xref: EHDAA2:0004449 xref: EMAPA:17769 xref: FMA:83711 xref: HBA:9708 xref: MA:0000961 xref: NCIT:C32309 xref: neuronames:218 xref: NLX:32548 xref: SCTID:70064002 xref: TAO:0001447 xref: UMLS:C0152289 {source="ncithesaurus:Choroid_Plexus_of_the_Lateral_Ventricle"} xref: VHOG:0001376 xref: ZFA:0001447 is_a: UBERON:0001886 ! choroid plexus intersection_of: UBERON:0001886 ! choroid plexus intersection_of: BFO:0000050 UBERON:0002285 ! part of telencephalic ventricle relationship: BFO:0000050 UBERON:0002285 ! part of telencephalic ventricle property_value: skos:prefLabel "choroid plexus of lateral ventricle" xsd:string [Term] id: UBERON:0002308 name: nucleus of brain def: "A neural nucleus that is part of the brain." [http://orcid.org/0000-0002-6601-2165] synonym: "brain nuclei" RELATED OMO:0003004 [ZFA:0005575] synonym: "brain nucleus" EXACT [] xref: EMAPA:35185 xref: FMA:83840 xref: MA:0000811 xref: NCIT:C49346 xref: SCTID:426465002 xref: UMLS:C1706993 {source="ncithesaurus:Brain_Nucleus"} xref: ZFA:0005575 is_a: UBERON:0000125 ! neural nucleus intersection_of: UBERON:0000125 ! neural nucleus intersection_of: BFO:0000050 UBERON:0000955 ! part of brain relationship: BFO:0000050 UBERON:0003528 ! part of brain gray matter property_value: skos:prefLabel "nucleus of brain" xsd:string [Term] id: UBERON:0002310 name: hippocampus fimbria def: "Regional part of fornix consisting of a prominent white matter structure adjacent to the hippocampus on the ventricular side continuous with the alveus. Near the splenium the fimbria separates from the hippocampus as the crus of the fornix. [adapted from Wikipedia] (MM: 2006-10-26)." [BIRNLEX:1502] subset: pheno_slim synonym: "fimbria" BROAD [BIRNLEX:1502] synonym: "fimbria (Vieussens)" RELATED [NeuroNames:187] synonym: "fimbria fornicis" RELATED OMO:0003011 [NeuroNames:187] synonym: "fimbria hippocampi" RELATED OMO:0003011 [NeuroNames:187, Wikipedia:Fimbria_of_hippocampus] synonym: "fimbria hippocampus" EXACT [] synonym: "fimbria of fornix" RELATED [NeuroNames:187] synonym: "fimbria of hippocampus" EXACT [FMA:83866] synonym: "fimbria of the fornix" EXACT [BIRNLEX:1502] synonym: "fimbria of the hippocampus" RELATED [NeuroNames:187] synonym: "fimbria-fornix" EXACT [BIRNLEX:1502] synonym: "hippocampal fimbria" EXACT [MP:0009324] synonym: "neuraxis fimbria" EXACT [] xref: BAMS:FI xref: BAMS:fi xref: BIRNLEX:1502 xref: BM:Tel-FI xref: DHBA:10575 xref: DMBA:17766 xref: EMAPA:35345 xref: FMA:83866 xref: HBA:9253 xref: MA:0000949 xref: MBA:603 xref: NCIT:C32606 xref: neuronames:187 {source="BIRNLEX:1502"} xref: SCTID:369096000 xref: UMLS:C0152315 {source="BIRNLEX:1502", source="ncithesaurus:Fimbria"} xref: Wikipedia:Fimbria_of_hippocampus is_a: UBERON:0011215 ! central nervous system cell part cluster relationship: BFO:0000050 UBERON:0000052 ! part of fornix of brain relationship: BFO:0000050 UBERON:0001954 {source="MA", source="NIFSTD"} ! part of Ammon's horn relationship: BFO:0000050 UBERON:0011299 ! part of white matter of telencephalon property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/6/6b/Gray749.png" xsd:anyURI property_value: skos:prefLabel "hippocampus fimbria" xsd:string [Term] id: UBERON:0002313 name: hippocampus pyramidal layer def: "A cytoarchitectural term denoting the layer of the hippocampus in which pyramidal cells are predominant. Its location is superficial to the Stratum oriens; it is deep to the Stratum radiatum in area CA1 and area CA2 and deep to the Stratum lucidum in area CA3 (Stephan-75) (NeuroNames)." [BIRNLEX:1444] comment: EDITOR_NOTE this layer changes in its depthwise spatial relation across its extent subset: pheno_slim synonym: "gyrus occipitalis inferior" RELATED OMO:0003011 [NeuroNames:156] synonym: "gyrus occipitalis tertius" RELATED OMO:0003011 [NeuroNames:156] synonym: "hippocampal pyramidal cell layer" RELATED [] synonym: "hippocampal pyramidal layer" RELATED [] synonym: "hippocampus pyramidal cell layer" RELATED [] synonym: "hippocampus stratum pyramidale" RELATED [] synonym: "pyramidal cell layer of the hippocampus" EXACT [BIRNLEX:1444] synonym: "pyramidal layer of hippocampus" EXACT [FMA:83895] synonym: "stratum pyramidale" EXACT [BIRNLEX:1444] synonym: "stratum pyramidale hippocampi" EXACT [BIRNLEX:1444] xref: BAMS:Py xref: BIRNLEX:1444 xref: BTO:0001066 xref: EMAPA:35409 xref: FMA:83895 xref: MA:0000956 xref: neuronames:156 {source="BIRNLEX:1444"} is_a: UBERON:0002305 ! layer of hippocampus intersection_of: UBERON:0002305 ! layer of hippocampus intersection_of: BSPO:0000107 UBERON:0007637 ! hippocampus stratum lucidum intersection_of: BSPO:0015014 UBERON:0005371 ! hippocampus stratum oriens relationship: BSPO:0000107 UBERON:0007637 ! hippocampus stratum lucidum relationship: BSPO:0015014 UBERON:0005371 ! hippocampus stratum oriens relationship: RO:0002473 CL:0000598 ! composed primarily of pyramidal neuron property_value: skos:prefLabel "hippocampus pyramidal layer" xsd:string [Term] id: UBERON:0002314 name: midbrain tectum def: "Dorsal part of the midbrain, consisting of the superior and inferior colliculi and the pretectal nuclei (MM)." [BIRNLEX:1032] subset: efo_slim subset: pheno_slim subset: uberon_slim synonym: "mesencephalic tectum" EXACT [ZFA:0000445] synonym: "neuraxis tectum" EXACT [] synonym: "t. mesencephali" RELATED OMO:0003011 [Wikipedia:Midbrain_tectum] synonym: "tectum" EXACT [] synonym: "tectum mesencephali" EXACT [BTO:0001793] synonym: "tectum mesencephalicum" RELATED OMO:0003011 [NeuroNames:465] synonym: "tectum of midbrain" RELATED [NeuroNames:465] xref: BAMS:MTec xref: BAMS:Tec xref: BIRNLEX:1032 xref: BM:MB-Tec xref: BTO:0001793 xref: DHBA:12291 xref: EFO:0000920 xref: EHDAA2:0004474 xref: EMAPA:19051 xref: FMA:83902 xref: HBA:9101 xref: MA:0000211 xref: MAT:0000451 xref: NCIT:C12460 xref: neuronames:465 {source="BIRNLEX:1032"} xref: SCTID:362394008 xref: TAO:0001353 xref: UMLS:C0039433 {source="ncithesaurus:Tectum_Mesencephali", source="BIRNLEX:1032"} xref: VHOG:0001388 xref: Wikipedia:Midbrain_tectum is_a: UBERON:0002616 ! regional part of brain relationship: BFO:0000050 UBERON:0001891 ! part of midbrain relationship: RO:0002202 UBERON:0005882 {source="Wikipedia"} ! develops from neural tube alar plate property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/c/cf/Gray685.png" xsd:anyURI property_value: skos:prefLabel "midbrain tectum" xsd:string [Term] id: UBERON:0002315 name: gray matter of spinal cord def: "The ridge-shaped grey matter of the spinal cord that extends longitudunally through the center of each half of the spinal cord, and are largely or entirely composed of nerve cell bodies and their dendrites and some supportive tissue." [MP:0008503] subset: pheno_slim synonym: "gray matter of spinal cord" EXACT [OBOL:automatic] synonym: "gray substance of spinal cord" EXACT [FMA:256580] synonym: "grey matter of spinal cord" EXACT [] synonym: "grey substance of spinal cord" EXACT [] synonym: "spinal cord gray matter" EXACT [OBOL:automatic] synonym: "spinal cord grey matter" EXACT [] synonym: "spinal cord grey substance" EXACT [OBOL:automatic] synonym: "substantia grisea medullae spinalis" EXACT OMO:0003011 [FMA:256580, FMA:TA] xref: BAMS:Scgrey xref: DHBA:146035048 xref: EMAPA:35792 xref: FMA:256580 xref: MA:0000002 xref: NCIT:C32696 xref: neuronames:2619 xref: NLXANAT:100204 xref: SCTID:279441003 xref: UMLS:C0475853 {source="ncithesaurus:Gray_Matter_of_the_Spinal_Cord"} is_a: UBERON:0002020 ! gray matter intersection_of: UBERON:0002020 ! gray matter intersection_of: BFO:0000050 UBERON:0002240 ! part of spinal cord relationship: BFO:0000050 UBERON:0002240 ! part of spinal cord relationship: RO:0002433 UBERON:0002240 ! contributes to morphology of spinal cord property_value: skos:prefLabel "gray matter of spinal cord" xsd:string [Term] id: UBERON:0002316 name: white matter def: "Neural tissue consisting of myelinated axons connecting grey matter areas of the central nervous system." [https://orcid.org/0000-0002-6601-2165, Wikipedia:White_matter] subset: uberon_slim subset: vertebrate_core synonym: "CNS tract/commissure" EXACT [ZFA:0001682] synonym: "CNS tracts and commissures" RELATED [TAO:0000145] synonym: "CNS white matter" RELATED [TAO:0002143] synonym: "neuronal white matter" EXACT [AEO:0001011] synonym: "substantia alba" RELATED OMO:0003011 [Wikipedia:White_matter] synonym: "white mater" RELATED [VHOG:0001764] synonym: "white matter of neuraxis" EXACT [FMA:83929] synonym: "white substance" EXACT [] xref: AEO:0000139 xref: AEO:0001011 xref: EMAPA:35927 xref: FMA:83929 xref: HBA:9218 xref: MA:0001135 xref: NCIT:C33892 xref: neuronames:2870 xref: NLX:412 xref: NLXANAT:101177 xref: PBA:294022044 xref: TAO:0000145 xref: TAO:0002142 xref: TAO:0002143 xref: UMLS:C0682708 {source="ncithesaurus:White_Matter"} xref: VHOG:0001764 xref: Wikipedia:White_matter xref: ZFA:0001682 is_a: UBERON:0011215 ! central nervous system cell part cluster relationship: RO:0002473 UBERON:0006135 ! composed primarily of myelinated nerve fiber property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/d/d7/Grey_matter_and_white_matter_-_very_high_mag.jpg" xsd:anyURI property_value: foaf:depiction "https://upload.wikimedia.org/wikipedia/commons/d/d2/Spinal_nerve.svg" xsd:anyURI property_value: skos:prefLabel "white matter" xsd:string [Term] id: UBERON:0002317 name: white matter of cerebellum def: "Regional part of cerebellum consisting of the myelinated axons lying deep to the granule cell layer, excluding the deep cerebellar nuclei and the cerebellar peduncles." [BIRNLEX:1562] subset: pheno_slim subset: vertebrate_core synonym: "cerebellar tracts/commissures" RELATED OMO:0003004 [ZFA:0001708] synonym: "cerebellar white matter" EXACT [] synonym: "cerebellum white matter" EXACT [] synonym: "medullary substance of cerebellum" RELATED [NeuroNames:691] synonym: "substantia centralis medullaris cerebelli" RELATED OMO:0003011 [NeuroNames:691] synonym: "substantia medullaris cerebelli" RELATED OMO:0003011 [NeuroNames:691] xref: BAMS:CB-white xref: BAMS:cbw xref: BIRNLEX:1562 xref: DMBA:16926 xref: EMAPA:35235 xref: FMA:83943 xref: HBA:9288 xref: MA:0002430 xref: NCIT:C49217 xref: neuronames:691 {source="BIRNLEX:1562"} xref: SCTID:362412009 xref: TAO:0002183 xref: UMLS:C0152381 {source="ncithesaurus:Cerebellum_White_Matter", source="BIRNLEX:1562"} xref: ZFA:0001708 is_a: UBERON:0002316 ! white matter relationship: RO:0002131 UBERON:0002037 {source="FMA-weakened", source="MA-weakened"} ! overlaps cerebellum property_value: skos:prefLabel "white matter of cerebellum" xsd:string [Term] id: UBERON:0002318 name: white matter of spinal cord def: "The regions of the spinal cord that are largely or entirely composed of myelinated nerve cell axons and contain few or no neural cell bodies or dendrites." [MP:0008027] subset: pheno_slim synonym: "spinal cord white matter" EXACT [] synonym: "spinal cord white matter of neuraxis" EXACT [OBOL:automatic] synonym: "spinal cord white substance" EXACT [OBOL:automatic] synonym: "substantia alba medullae spinalis" EXACT OMO:0003011 [FMA:83945, FMA:TA] synonym: "white matter of neuraxis of spinal cord" EXACT [OBOL:automatic] synonym: "white substance of spinal cord" EXACT [OBOL:automatic] xref: BAMS:SCwhite xref: DHBA:146035088 xref: EMAPA:35795 xref: FMA:83945 xref: MA:0000910 xref: NCIT:C33893 xref: SCTID:279436006 xref: UMLS:C0458457 {source="ncithesaurus:White_Matter_of_the_Spinal_Cord"} is_a: UBERON:0002316 ! white matter intersection_of: UBERON:0002316 ! white matter intersection_of: BFO:0000050 UBERON:0002240 ! part of spinal cord relationship: BFO:0000050 UBERON:0002240 ! part of spinal cord relationship: RO:0002433 UBERON:0002240 ! contributes to morphology of spinal cord property_value: skos:prefLabel "white matter of spinal cord" xsd:string [Term] id: UBERON:0002319 name: mesangium def: "The inner layer of the glomerulus, within the basement membrane surrounding the glomerular capillaries." [https://sourceforge.net/p/obo/foundational-model-of-anatomy-fma-requests/13/, Wikipedia:Mesangium] subset: human_reference_atlas subset: pheno_slim subset: uberon_slim xref: BTO:0002494 xref: EMAPA:36561 {source="MA:th"} xref: FMA:84139 xref: MA:0002617 xref: NCIT:C33101 xref: UMLS:C0017655 {source="ncithesaurus:Mesangium"} xref: Wikipedia:Mesangium is_a: BFO:0000002 is_a: UBERON:0000119 ! cell layer intersection_of: UBERON:0000119 ! cell layer intersection_of: RO:0001025 UBERON:0005777 ! located in glomerular basement membrane intersection_of: RO:0002473 CL:0000650 ! composed primarily of mesangial cell relationship: BFO:0000050 UBERON:0000074 ! part of renal glomerulus relationship: BFO:0000050 UBERON:0005215 ! part of kidney interstitium relationship: RO:0001025 UBERON:0005777 ! located in glomerular basement membrane relationship: RO:0002221 UBERON:0004212 ! surrounds glomerular capillary relationship: RO:0002473 CL:0000650 ! composed primarily of mesangial cell property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0002320 name: glomerular mesangium def: "A thin membrane which helps to support the capillary loops in a renal glomerulus. It is connective tissue composed of mesangial cells - myofibroblasts phenotypically related to vascular smooth muscle cells (muscle, smooth, vascular), phagocytes and the mesangial extracellular matrix." [MESH:A05.810.453.736.520.380, Wikipedia:Glomerular_mesangium] subset: human_reference_atlas subset: pheno_slim subset: uberon_slim xref: EMAPA:27961 xref: FMA:84140 xref: GAID:430 xref: MA:0002606 xref: MESH:D005920 xref: SCTID:244574009 xref: Wikipedia:Glomerular_mesangium is_a: UBERON:0003891 ! stroma relationship: BFO:0000050 UBERON:0002319 ! part of mesangium relationship: BFO:0000050 UBERON:0004190 {source="GO"} ! part of renal glomerulus vasculature relationship: RO:0002433 UBERON:0000074 ! contributes to morphology of renal glomerulus property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0002321 name: extraglomerular mesangium def: "The tissue comprised of mesangial cells that fill the triangular space between the macula densa and the afferent and efferent arterioles of the juxtaglomerular apparatus." [ISBN:0-683-40008-8, MP:0011340] comment: EDITOR_NOTE check MA part_ofs - should be spatially disjoint from renal glomerulus? subset: pheno_slim xref: EMAPA:28278 xref: FMA:84141 xref: MA:0002602 is_a: UBERON:0003891 ! stroma relationship: BFO:0000050 UBERON:0002303 {source="MA"} ! part of juxtaglomerular apparatus relationship: BFO:0000050 UBERON:0002319 {source="MA"} ! part of mesangium [Term] id: UBERON:0002322 name: periventricular nucleus def: "A thin sheet of small neurons located in the wall of the third ventricle, a composite structure of the hypothalamus." [Wikipedia:Periventricular_nucleus] subset: uberon_slim subset: vertebrate_core synonym: "periventricular nuclei" RELATED OMO:0003004 [ZFA:0000260] synonym: "ventral zone of periventricular hypothalamus" EXACT [ZFA:0000260] xref: FMA:84354 xref: TAO:0000260 xref: Wikipedia:Periventricular_nucleus xref: ZFA:0000260 is_a: UBERON:0002308 ! nucleus of brain [Term] id: UBERON:0002323 name: coelemic cavity lumen def: "The cavity within the body of all animals higher than the coelenterates and certain primitive worms, formed by the splitting of the embryonic mesoderm into two layers. In mammals it forms the peritoneal, pleural, and pericardial cavities." [BTO:0001707] comment: EDITOR_NOTE check the FMA placement here; ncit placement of body cavity here probably not correct subset: uberon_slim subset: vertebrate_core synonym: "body cavity" BROAD [BTO:0001707] synonym: "celom" RELATED [BTO:0001707] synonym: "coelom" RELATED [] synonym: "coelome" RELATED [BTO:0001707] synonym: "coelomic cavity" EXACT [EHDAA2:0000267] synonym: "coelomic cavity lumen" EXACT [EHDAA2:0000267] synonym: "hemocoel" RELATED [FBbt:00005060] synonym: "main body cavity" EXACT [] synonym: "space of body compartment" EXACT [FMA:85006] synonym: "ventral body cavity" NARROW [NCBITaxon:7742] xref: AEO:0000186 xref: BTO:0001707 xref: EHDAA2:0000267 xref: FBbt:00005060 {sssom:mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"} xref: FMA:85006 xref: galen:BodyCavity xref: NCIT:C25444 xref: RETIRED_EHDAA2:0003186 xref: SCTID:361348008 xref: TAO:0001438 xref: UMLS:C0333343 {source="ncithesaurus:Cavity"} is_a: BFO:0000002 is_a: UBERON:0002553 ! anatomical cavity relationship: RO:0002494 UBERON:0003886 {evidence="definitional"} ! transformation of future coelemic cavity lumen relationship: RO:0002572 UBERON:0011997 ! luminal space of coelom property_value: skos:prefLabel "coelemic cavity lumen" xsd:string [Term] id: UBERON:0002324 name: muscle of back def: "Any muscle organ that is part of a back [Automatically generated definition]." [OBOL:automatic] subset: human_reference_atlas synonym: "back muscle" EXACT [] synonym: "back muscle organ" EXACT [OBOL:automatic] synonym: "muscle organ of back" EXACT [OBOL:automatic] xref: EMAPA:35161 xref: FMA:85216 xref: MA:0000496 is_a: UBERON:0001774 ! skeletal muscle of trunk is_a: UBERON:0005174 ! dorsal region element intersection_of: UBERON:0014892 ! skeletal muscle organ, vertebrate intersection_of: BFO:0000050 UBERON:0001137 ! part of dorsum relationship: BFO:0000050 UBERON:0004469 {source="prolog"} ! part of musculature of back property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "muscle of back" xsd:string [Term] id: UBERON:0002325 name: epithelium of urethra def: "The urethra is a renal system organ that carries urine from the bladder to outside the body. The epithelium is the tubular, planar layer of cells through which the urine passes.." [GO:0061071] synonym: "epithelial tissue of urethra" EXACT [OBOL:automatic] synonym: "urethra epithelial tissue" EXACT [OBOL:automatic] synonym: "urethra epithelium" EXACT [] synonym: "urethral epithelium" RELATED [] synonym: "urethral plate" RELATED [EMAPA:31518] synonym: "urethral seam" RELATED [EMAPA:31518] xref: EMAPA:31518 xref: FMA:85275 xref: MA:0001686 xref: NCIT:C49309 xref: UMLS:C1710584 {source="ncithesaurus:Urethra_Epithelium"} is_a: UBERON:0003914 {source="GO"} ! epithelial tube is_a: UBERON:0005911 ! endo-epithelium is_a: UBERON:0006555 ! excretory tube intersection_of: UBERON:0000483 ! epithelium intersection_of: BFO:0000050 UBERON:0000057 ! part of urethra relationship: BFO:0000050 UBERON:0000057 ! part of urethra [Term] id: UBERON:0002326 name: lamina propria of urethra def: "A lamina propria that is part of a urethra [Automatically generated definition]." [OBOL:automatic] synonym: "lamina propria mucosa of urethra" EXACT [OBOL:automatic] synonym: "lamina propria mucosae of urethra" EXACT [OBOL:automatic] synonym: "urethra lamina propria" EXACT [] synonym: "urethra lamina propria mucosa" EXACT [OBOL:automatic] synonym: "urethra lamina propria mucosae" EXACT [OBOL:automatic] synonym: "urethral lamina propria" RELATED [] xref: EMAPA:37785 {source="MA:th"} xref: FMA:85276 xref: MA:0001689 is_a: UBERON:0000030 ! lamina propria intersection_of: UBERON:0000030 ! lamina propria intersection_of: BFO:0000050 UBERON:0000057 ! part of urethra relationship: BFO:0000050 UBERON:0000057 ! part of urethra [Term] id: UBERON:0002327 name: trunk of intercostal nerve synonym: "intercostal nerve trunk" EXACT [] synonym: "intercostal neural trunk" EXACT [] xref: EMAPA:37720 {source="MA:th"} xref: FMA:85315 xref: MA:0001176 is_a: UBERON:0005476 ! spinal nerve trunk intersection_of: UBERON:0002464 ! nerve trunk intersection_of: BFO:0000050 UBERON:0003727 ! part of intercostal nerve relationship: BFO:0000050 UBERON:0003727 ! part of intercostal nerve [Term] id: UBERON:0002328 name: notochord def: "A flexible rod-shaped body found in embryos of all chordates. It is composed of cells derived from the mesoderm and defines the primitive axis of the embryo. In some chordates, it persists throughout life as the main axial support of the body, while in most vertebrates it becomes the nucleus pulposus of the intervertebral disc. The notochord is found ventral to the neural tube." [http://tolweb.org/Chordata/2499, https://github.com/obophenotype/uberon/issues/25, https://github.com/obophenotype/uberon/issues/271, ISBN:0815318960, Wikipedia:Notochord] comment: The notochord appears early in embryogeny and plays an important role in promoting or organizing the embryonic development of nearby structures. In most adult chordates the notochord disappears or becomes highly modified. In some non-vertebrate chordates and fishes the notochord persists as a laterally flexible but incompressible skeletal rod that prevents telescopic collapse of the body during swimming[TOLWEB] subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "embryonic notocord" EXACT [] synonym: "notochorda" RELATED OMO:0003011 [Wikipedia:Notochord] synonym: "notocord" EXACT [ZFA:0000135] xref: AAO:0000327 xref: BTO:0001768 xref: CALOHA:TS-0690 xref: EHDAA2:0001277 xref: EHDAA:1241 xref: EHDAA:6021 xref: EMAPA:16191 xref: EV:0100002 xref: FMA:85521 xref: GAID:1311 xref: http://evolution.berkeley.edu/evolibrary/images/history/notochords.jpg xref: MAT:0000281 xref: MESH:D009672 xref: NCIT:C12463 xref: SCTID:308820002 xref: TAO:0000135 xref: UMLS:C0028439 {source="ncithesaurus:Notochord"} xref: VHOG:0000199 xref: VSAO:0000032 xref: Wikipedia:Notochord xref: XAO:0000055 xref: ZFA:0000135 is_a: UBERON:0000062 {source="PMID:15890825"} ! organ is_a: UBERON:0000481 {source="VSAO"} ! multi-tissue structure is_a: UBERON:0004121 ! ectoderm-derived structure relationship: BFO:0000050 UBERON:0011137 ! part of axial skeletal system relationship: BSPO:0000098 UBERON:0001555 ! digestive tract relationship: BSPO:0000102 UBERON:0001049 ! neural tube relationship: RO:0002202 UBERON:0004880 {source="ZFA"} ! develops from chordamesoderm relationship: RO:0002202 UBERON:0006267 {source="EHDAA2"} ! develops from notochordal plate relationship: RO:0002488 UBERON:0000068 ! existence starts during embryo stage relationship: RO:0003000 PR:000014841 ! produces sonic hedgehog protein property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/6/64/Gray19_with_color.png" xsd:anyURI property_value: skos:prefLabel "notochord" xsd:string property_value: terms:contributor https://orcid.org/0000-0002-6601-2165 property_value: terms:contributor https://orcid.org/0000-0003-3162-7490 [Term] id: UBERON:0002329 name: somite def: "Somites are spheres of epithelial cells that form sequentially along the anterior-posterior axis of the embryo through mesenchymal to epithelial transition of the presomitic mesoderm." [DOI:10.1111/j.1439-0426.2012.01987.x, Wikipedia:Somite] comment: When the somite becomes segmented from the segmental plate, it is composed of an epithelial sac enclosing mesenchymal somitocoel cells. Thereafter the somite differentiates into two parts, the ventro-medial mesenchymal sclerotome and the dorso-lateral epithelial dermomyotome. This change in the epithelial somite depends on surrounding tissue [PMID:15906248] subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "epimere" RELATED [ISBN:0073040584] synonym: "epimere mesoderm" RELATED [] synonym: "epithelial somite" RELATED [https://github.com/obophenotype/uberon/wiki/The-neural-crest] synonym: "mesodermal cluster" BROAD [GO:0001756] synonym: "somites" RELATED OMO:0003004 [] synonym: "somitic mesoderm" RELATED [] synonym: "somitus" RELATED OMO:0003011 [Wikipedia:Somite] xref: AAO:0010569 xref: AEO:0001015 xref: BTO:0001558 xref: EHDAA2:0003436 xref: EHDAA:366 xref: EHDAA:699 xref: EMAPA:31169 xref: FMA:85522 xref: GAID:1306 xref: MAT:0000068 xref: MESH:D019170 xref: MIAA:0000068 xref: NCIT:C34302 xref: TAO:0000155 xref: UMLS:C0376449 {source="ncithesaurus:Somite"} xref: VHOG:0000191 xref: Wikipedia:Somite xref: XAO:0000058 xref: ZFA:0000155 is_a: BFO:0000002 is_a: UBERON:0005423 ! developing anatomical structure is_a: UBERON:0007503 {source="EHDAA2"} ! epithelial vesicle relationship: RO:0002202 UBERON:0003059 {source="ZFA"} ! develops from presomitic mesoderm property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/6/64/Gray19_with_color.png" xsd:anyURI property_value: RO:0002161 NCBITaxon:7712 {source="PMID:17237766"} property_value: skos:prefLabel "somite" xsd:string [Term] id: UBERON:0002330 name: exocrine system def: "Anatomical system that consists of the glands and parts of glands that produce exocrine secretions and help to integrate and control bodily metabolic activity. Exocrine glands are glands that secrete their products (hormones) into ducts (duct glands). They are the counterparts to endocrine glands, which secrete their products (hormones) directly into the bloodstream (ductless glands) or release hormones (paracrines) that affect only target cells nearby the release site. [Wikipedia]." [Wikipedia:Exocrine_gland] subset: human_reference_atlas subset: pheno_slim subset: uberon_slim synonym: "exocrine glandular system" EXACT [EHDAA2:0002225] xref: CALOHA:TS-2057 xref: EHDAA2:0002225 xref: EMAPA:35329 xref: FMA:85539 xref: MA:0002411 xref: NCIT:C12957 xref: UMLS:C1516995 {source="ncithesaurus:Exocrine_System"} xref: Wikipedia:Exocrine_gland xref: WikipediaCategory:Exocrine_system is_a: UBERON:0000467 ! anatomical system disjoint_from: UBERON:0002390 ! hematopoietic system disjoint_from: UBERON:0002405 ! immune system disjoint_from: UBERON:0002416 ! integumental system disjoint_from: UBERON:0002423 ! hepatobiliary system disjoint_from: UBERON:0004456 ! entire sense organ system disjoint_from: UBERON:8450002 ! excretory system relationship: RO:0002473 UBERON:0002365 ! composed primarily of exocrine gland relationship: RO:0002492 UBERON:0000066 ! existence ends during fully formed stage property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "exocrine system" xsd:string [Term] id: UBERON:0002331 name: umbilical cord def: "The connecting cord from the developing embryo to the placenta." [ISBN:0-683-40008-8, MP:0001725, PMID:9144284, Wikipedia:Umbilical_cord] comment: See notes for connecting stalk subset: efo_slim subset: human_reference_atlas subset: pheno_slim subset: uberon_slim synonym: "birth cord" RELATED [Wikipedia:Umbilical_cord] synonym: "chorda umbilicalis" EXACT OMO:0003011 [MP:0012134] synonym: "connecting stalk" RELATED [] synonym: "funiculus umbilicalis" EXACT OMO:0003011 [MP:0012134] synonym: "funiculus umbilicalis" RELATED OMO:0003011 [Wikipedia:Umbilical_cord] synonym: "yolk stalk" RELATED [BTO:0001415] xref: BTO:0001415 xref: CALOHA:TS-1078 xref: EFO:0001415 xref: EHDAA2:0000312 xref: EHDAA:158 xref: EMAPA:26115 xref: EV:0100127 xref: FMA:85541 xref: GAID:517 xref: MAT:0000280 xref: MESH:D014470 xref: MIAA:0000280 xref: NCIT:C34320 xref: SCTID:280644003 xref: UMLS:C0041633 {source="ncithesaurus:Umbilical_Cord"} xref: Wikipedia:Umbilical_cord is_a: BFO:0000002 is_a: UBERON:0000478 ! extraembryonic structure relationship: RO:0002176 UBERON:0000922 ! connects embryo relationship: RO:0002176 UBERON:0001987 ! connects placenta relationship: RO:0002202 UBERON:0007806 ! develops from connecting stalk property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/f/f3/Umbilicalcord.jpg" xsd:anyURI property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/placenta-full-term-female/v1.1/assets/3d-vh-f-placenta-full-term.glb" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0002333 name: pulmonary trunk def: "An arterial trunk which is continuous with the heart and branches into the pulmonary arteries." [http://orcid.org/0000-0002-6601-2165] subset: efo_slim subset: human_reference_atlas subset: pheno_slim subset: uberon_slim synonym: "main pulmonary artery" RELATED [Wikipedia:Pulmonary_artery] synonym: "pulmonary artery (trunk)" EXACT [] synonym: "trunk of pulmonary arterial tree" EXACT [] xref: EHDAA2:0001576 xref: EHDAA:9831 xref: EMAPA:17015 xref: FMA:8612 xref: galen:PulmonaryTrunk xref: MA:0002033 xref: NCIT:C116918 xref: VHOG:0001134 is_a: UBERON:0001637 {source="MA"} ! artery relationship: BFO:0000050 UBERON:0008886 ! part of pulmonary vascular system relationship: RO:0002150 UBERON:0000948 ! continuous with heart relationship: RO:0002170 UBERON:0002080 ! connected to heart right ventricle property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/blood-vasculature-female/v1.3/assets/3d-vh-f-blood-vasculature.glb" xsd:anyURI property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/blood-vasculature-male/v1.3/assets/3d-vh-m-blood-vasculature.glb" xsd:anyURI property_value: foaf:depiction "https://upload.wikimedia.org/wikipedia/commons/d/db/Alveoli_diagram.png" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "pulmonary trunk" xsd:string [Term] id: UBERON:0002334 name: submandibular duct def: "The duct of the submadibular gland that opens at the sublingual papilla near the frenulum of the tongue." [ISBN:0-683-40008-8, MP:0009525] subset: human_reference_atlas subset: pheno_slim subset: uberon_slim synonym: "ductus submandibularis" RELATED [BTO:0004556] synonym: "ductus submaxillaris" RELATED OMO:0003011 [Wikipedia:Submandibular_duct] synonym: "submandibular salivary duct" RELATED [] synonym: "submaxillar gland duct" RELATED [BTO:0004556] synonym: "submaxillary duct" RELATED [] synonym: "Wharton's duct" RELATED INCONSISTENT [FMA:59899, Wikipedia:Submandibular_duct] xref: BTO:0004556 xref: EMAPA:35833 xref: FMA:86266 xref: MA:0002698 xref: NCIT:C33649 xref: SCTID:181237009 xref: UMLS:C0227472 {source="ncithesaurus:Submandibular_Duct"} xref: Wikipedia:Submandibular_duct is_a: UBERON:0001837 ! duct of salivary gland intersection_of: UBERON:0001837 ! duct of salivary gland intersection_of: BFO:0000050 UBERON:0001736 ! part of submandibular gland relationship: BFO:0000050 UBERON:0001736 ! part of submandibular gland relationship: channels_from UBERON:0001736 ! submandibular gland relationship: RO:0002433 UBERON:0001736 ! contributes to morphology of submandibular gland property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/7/7d/Gray1024.png" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0002335 name: macula densa def: "The macula densa is an area of specialized cells in the distal tubule that makes contact with the vascular pole of the glomerulus[GO]." [GO:0072024, Wikipedia:Macula_densa] subset: human_reference_atlas subset: pheno_slim subset: uberon_slim xref: BTO:0003940 xref: EMAPA:28399 xref: FMA:86333 xref: MA:0002603 xref: NCIT:C33043 xref: SCTID:244657003 xref: UMLS:C0227662 {source="ncithesaurus:Macula_Densa"} xref: Wikipedia:Macula_densa is_a: UBERON:0004211 ! nephron epithelium relationship: BFO:0000050 UBERON:0002303 {source="MA"} ! part of juxtaglomerular apparatus relationship: BFO:0000050 UBERON:0004135 {source="GO"} ! part of distal tubule property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0002336 name: corpus callosum def: "White matter structure containing massive numbers of commissural fibers connecting cortical areas in the two cerebral hemispheres. It is subdivided into a genu, a rostrum, a body, and a splenium. (MM)." [BIRNLEX:1087] subset: efo_slim subset: human_reference_atlas subset: pheno_slim subset: uberon_slim xref: BAMS:CC xref: BAMS:cc xref: BIRNLEX:1087 xref: BM:Tel-CC xref: BTO:0000615 xref: CALOHA:TS-0180 xref: DHBA:10561 xref: EFO:0001390 xref: EMAPA:35253 xref: EV:0100305 xref: FMA:86464 xref: GAID:683 xref: HBA:9222 xref: MA:0000188 xref: MAT:0000286 xref: MBA:776 xref: MESH:D003337 xref: MIAA:0000286 xref: NCIT:C12446 xref: neuronames:191 xref: SCTID:362354006 xref: UMLS:C0010090 {source="BIRNLEX:1087", source="ncithesaurus:Corpus_Callosum"} xref: VHOG:0001608 xref: Wikipedia:Corpus_callosum is_a: UBERON:0002473 {source="FMA-part_of", source="MA"} ! intercerebral commissure is_a: UBERON:0005340 {source="MP"} ! dorsal telencephalic commissure relationship: RO:0002162 NCBITaxon:9347 {source="Wikipedia"} ! in taxon Eutheria relationship: RO:0002433 UBERON:0001893 ! contributes to morphology of telencephalon property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/a/aa/Gray733.png" xsd:anyURI property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/brain-female/v1.4/assets/3d-allen-f-brain.glb" xsd:anyURI property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/brain-male/v1.4/assets/3d-allen-m-brain.glb" xsd:anyURI property_value: RO:0002161 NCBITaxon:9255 {source="Wikipedia"} property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "corpus callosum" xsd:string [Term] id: UBERON:0002337 name: endometrial stroma def: "The layer of connective tissue comprised of the endometrial lining of the uterus which fluctuates in thickness throughout the menstrual cycle." [ncithesaurus:Endometrial_Stroma] subset: human_reference_atlas synonym: "endometrium stroma" EXACT [] synonym: "stroma of endometrium" EXACT [] xref: CALOHA:TS-1266 xref: EMAPA:35310 xref: FMA:86487 xref: MA:0002734 xref: NCIT:C32516 xref: SCTID:254115004 xref: UMLS:C0227849 {source="ncithesaurus:Endometrial_Stroma"} is_a: UBERON:0003891 ! stroma is_a: UBERON:0005156 ! reproductive structure intersection_of: UBERON:0003891 ! stroma intersection_of: BFO:0000050 UBERON:0001295 ! part of endometrium relationship: BFO:0000050 UBERON:0001295 ! part of endometrium property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0002338 name: lamina propria of bronchus def: "A lamina propria that is part of a bronchus [Automatically generated definition]." [OBOL:automatic] synonym: "bronchi lamina propria" EXACT [OBOL:automatic] synonym: "bronchi lamina propria mucosa" EXACT [OBOL:automatic] synonym: "bronchi lamina propria mucosae" EXACT [OBOL:automatic] synonym: "bronchial lamina propria" RELATED [EMAPA:35194] synonym: "bronchial trunk lamina propria" EXACT [OBOL:automatic] synonym: "bronchial trunk lamina propria mucosa" EXACT [OBOL:automatic] synonym: "bronchial trunk lamina propria mucosae" EXACT [OBOL:automatic] synonym: "bronchus lamina propria" EXACT [] synonym: "bronchus lamina propria mucosa" EXACT [OBOL:automatic] synonym: "bronchus lamina propria mucosae" EXACT [OBOL:automatic] synonym: "lamina propria mucosa of bronchi" EXACT [OBOL:automatic] synonym: "lamina propria mucosa of bronchial trunk" EXACT [OBOL:automatic] synonym: "lamina propria mucosa of bronchus" EXACT [OBOL:automatic] synonym: "lamina propria mucosae of bronchi" EXACT [OBOL:automatic] synonym: "lamina propria mucosae of bronchial trunk" EXACT [OBOL:automatic] synonym: "lamina propria mucosae of bronchus" EXACT [OBOL:automatic] synonym: "lamina propria of bronchi" EXACT [OBOL:automatic] synonym: "lamina propria of bronchial trunk" EXACT [OBOL:automatic] xref: EMAPA:35194 xref: FMA:86619 xref: MA:0001836 xref: NCIT:C49212 xref: UMLS:C1707054 {source="ncithesaurus:Bronchus_Lamina_Propria"} is_a: UBERON:0000031 ! lamina propria of trachea intersection_of: UBERON:0000030 ! lamina propria intersection_of: BFO:0000050 UBERON:0002185 ! part of bronchus relationship: BFO:0000050 UBERON:0000410 {is_inferred="true", source="https://github.com/obophenotype/uberon/wiki/Inferring-part-of-relationships"} ! part of bronchial mucosa property_value: skos:prefLabel "lamina propria of bronchus" xsd:string [Term] id: UBERON:0002339 name: epithelium of lobar bronchus def: "The tissue made up of epithelial cells that lines the inside of the lobar bronchus." [GO:0060481] subset: human_reference_atlas synonym: "epithelial tissue of lobar bronchus" EXACT [OBOL:automatic] synonym: "epithelial tissue of secondary bronchus" EXACT [OBOL:automatic] synonym: "epithelium of secondary bronchus" EXACT [OBOL:automatic] synonym: "lobar bronchial epithelium" EXACT [] synonym: "lobar bronchus epithelial tissue" EXACT [OBOL:automatic] synonym: "lobar bronchus epithelium" EXACT [] synonym: "secondary bronchus epithelial tissue" EXACT [OBOL:automatic] synonym: "secondary bronchus epithelium" EXACT [OBOL:automatic] xref: EMAPA:32695 xref: FMA:86624 xref: MA:0001842 is_a: UBERON:0000115 ! lung epithelium is_a: UBERON:0002031 ! epithelium of bronchus intersection_of: UBERON:0000483 ! epithelium intersection_of: BFO:0000050 UBERON:0002183 ! part of lobar bronchus relationship: BFO:0000050 UBERON:0002183 ! part of lobar bronchus relationship: BFO:0000051 CL:0002329 ! has part basal epithelial cell of tracheobronchial tree relationship: BFO:0000051 CL:0002332 ! has part multiciliated epithelial cell of the bronchus relationship: BFO:0000051 CL:0017000 ! has part pulmonary ionocyte property_value: RO:0002175 NCBITaxon:9606 property_value: terms:contributor https://orcid.org/0000-0001-6677-8489 [Term] id: UBERON:0002341 name: epithelium of segmental bronchus def: "An epithelium that is part of a segmental bronchus [Automatically generated definition]." [OBOL:automatic] subset: human_reference_atlas synonym: "epithelial tissue of segmental bronchus" EXACT [OBOL:automatic] synonym: "epithelial tissue of tertiary bronchus" EXACT [OBOL:automatic] synonym: "epithelium of tertiary bronchus" EXACT [OBOL:automatic] synonym: "segmental bronchial epithelium" EXACT [] synonym: "segmental bronchus epithelial tissue" EXACT [OBOL:automatic] synonym: "segmental bronchus epithelium" EXACT [] synonym: "tertiary bronchus epithelial tissue" EXACT [OBOL:automatic] synonym: "tertiary bronchus epithelium" EXACT [OBOL:automatic] xref: EMAPA:37740 {source="MA:th"} xref: FMA:86626 xref: MA:0001850 is_a: UBERON:0000115 ! lung epithelium is_a: UBERON:0002031 ! epithelium of bronchus is_a: UBERON:0006934 ! sensory epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: BFO:0000050 UBERON:0002184 ! part of segmental bronchus relationship: BFO:0000050 UBERON:0002184 ! part of segmental bronchus relationship: BFO:0000051 CL:0000158 ! has part club cell relationship: BFO:0000051 CL:0002208 ! has part brush cell of bronchus relationship: BFO:0000051 CL:0002329 ! has part basal epithelial cell of tracheobronchial tree relationship: BFO:0000051 CL:0002332 ! has part multiciliated epithelial cell of the bronchus relationship: BFO:0000051 CL:0017000 ! has part pulmonary ionocyte relationship: BFO:0000051 CL:1000143 ! has part lung goblet cell relationship: BFO:0000051 CL:1000223 ! has part pulmonary neuroendocrine cell property_value: RO:0002175 NCBITaxon:9606 property_value: terms:contributor https://orcid.org/0000-0001-6677-8489 [Term] id: UBERON:0002342 name: neural crest def: "A specialized region of ectoderm found between the neural ectoderm (neural plate) and non-neural ectoderm and composed of highly migratory pluripotent cells that delaminate in early embryonic development from the dorsal neural tube and give rise to an astounding variety of differentiated cell types[MP]." [MP:0009846] comment: Gene notes: Many factors and genes, such as Pax3 (Tremblay et al., 1995), slug (Nieto et al., 1994), AP-2 (Zhang et al., 1996; Schorle et al., 1996), and Wnt-1/3a (Ikeya et al., 1997) are expressed in the dorsal most region of the neural tube, and have been shown to be involved in the generation of neural crest cells. subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "crista neuralis" RELATED OMO:0003011 [Wikipedia:Neural_crest] synonym: "NC" EXACT OMO:0003000 [XAO:0000048] synonym: "neural crest material" RELATED [VHOG:0000057] xref: AAO:0010578 xref: BTO:0001764 xref: CALOHA:TS-0676 xref: EHDAA2:0004419 xref: EMAPA:32737 xref: FMA:86666 xref: GAID:1310 xref: MAT:0000066 xref: MESH:D009432 xref: MIAA:0000066 xref: NCIT:C34222 xref: neuronames:1366 xref: SCTID:361462002 xref: UMLS:C0027789 {source="ncithesaurus:Neural_Crest"} xref: VHOG:0000057 xref: Wikipedia:Neural_crest xref: XAO:0000048 xref: ZFA:0000045 is_a: UBERON:0004121 ! ectoderm-derived structure is_a: UBERON:0010316 ! germ layer / neural crest relationship: BFO:0000050 UBERON:0002346 {source="XAO", source="https://github.com/obophenotype/uberon/wiki/The-neural-crest"} ! part of neurectoderm relationship: RO:0002202 UBERON:0003075 {source="BTO"} ! develops from neural plate relationship: RO:0002202 UBERON:0005062 {source="PMID:11523831"} ! develops from neural fold relationship: RO:0002473 CL:0000333 ! composed primarily of migratory neural crest cell relationship: RO:0002488 UBERON:0000110 {source="PMID:11523831"} ! existence starts during neurula stage property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/5/5f/Gray644.png" xsd:anyURI property_value: foaf:depiction "https://upload.wikimedia.org/wikipedia/commons/8/8f/Neural_Crest.png" xsd:anyURI property_value: skos:prefLabel "neural crest" xsd:string [Term] id: UBERON:0002343 name: abdomen musculature def: "Set of all muscles in abdomen." [OBOL:automatic] subset: pheno_slim subset: vertebrate_core synonym: "abdominal musculature" EXACT [] synonym: "muscle group of abdomen" EXACT [FMA:71294] synonym: "muscles of abdomen" EXACT [FMA:71294] synonym: "musculature of abdomen" EXACT [] synonym: "musculature of abdominal wall" EXACT [FMA:86917] synonym: "set of muscles of abdomen" EXACT [FMA:71294] xref: FMA:71294 xref: FMA:86917 xref: TAO:0001327 xref: ZFA:0001327 is_a: UBERON:0004479 ! musculature of trunk intersection_of: UBERON:0001015 ! musculature intersection_of: BFO:0000050 UBERON:0000916 ! part of abdomen relationship: BFO:0000050 UBERON:0000916 ! part of abdomen property_value: skos:prefLabel "abdomen musculature" xsd:string [Term] id: UBERON:0002345 name: descending thoracic aorta def: "The part of the aorta that extends from the arch of the aorta to the diaphragm, and from which arises numerous branches that supply oxygenated blood to the chest cage and the organs within the chest." [MP:0009868] subset: efo_slim subset: human_reference_atlas subset: pheno_slim xref: EFO:0002527 xref: EMAPA:18605 xref: FMA:87217 xref: MA:0002572 xref: SCTID:181301002 is_a: UBERON:0013522 ! subdivision of tube relationship: BFO:0000050 UBERON:0001514 ! part of descending aorta relationship: BFO:0000050 UBERON:0001515 ! part of thoracic aorta relationship: RO:0002433 UBERON:0001514 ! contributes to morphology of descending aorta relationship: RO:0002433 UBERON:0001515 ! contributes to morphology of thoracic aorta property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "descending thoracic aorta" xsd:string [Term] id: UBERON:0002346 name: neurectoderm def: "Embryonic ectoderm that gives rise to nervous tissue." [Wikipedia:Neuroectoderm] subset: uberon_slim subset: vertebrate_core synonym: "epithelium tubi neuralis; neuroectoderma" RELATED OMO:0003011 [Wikipedia:Neuroectoderm] synonym: "neuaral ectoderm" RELATED [] synonym: "neural ectoderm" EXACT [] synonym: "neuroectoderm" EXACT [] synonym: "presumptive central nervous system" RELATED [] synonym: "ventral neurogenic region" RELATED [VHOG:0000150] xref: AAO:0011074 xref: BILA:0000039 xref: CALOHA:TS-1212 xref: EHDAA2:0001248 xref: EHDAA:1498 xref: EHDAA:255 xref: EMAPA:16073 xref: EV:0100004 xref: FBbt:00001057 {sssom:mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"} xref: FMA:87657 xref: MAT:0000176 xref: MIAA:0000176 xref: NCIT:C34228 xref: TAO:0001120 xref: UMLS:C1518271 {source="ncithesaurus:Neuroectoderm"} xref: VHOG:0000150 xref: Wikipedia:Neuroectoderm xref: XAO:0000042 xref: ZFA:0001120 is_a: UBERON:0000923 ! germ layer is_a: UBERON:0004121 ! ectoderm-derived structure relationship: BFO:0000051 CL:0000133 ! has part neurectodermal cell property_value: skos:prefLabel "neurectoderm" xsd:string [Term] id: UBERON:0002347 name: thoracic vertebra def: "A thoracic vertebra endochondral element that is composed primarily of a bone tissue." [OBOL:automatic] subset: human_reference_atlas subset: pheno_slim subset: uberon_slim synonym: "dorsal vertebra" EXACT [] synonym: "thorax vertebra" EXACT [OBOL:automatic] synonym: "vertebra of thorax" EXACT [OBOL:automatic] synonym: "vertebra thoracica" EXACT [] xref: EMAPA:18011 xref: FMA:9139 xref: GAID:244 xref: MA:0000314 xref: MESH:D013904 xref: NCIT:C12798 xref: SCTID:181821009 xref: UMLS:C0039987 {source="ncithesaurus:Thoracic_Vertebra"} xref: Wikipedia:Thoracic_vertebrae is_a: UBERON:0002412 ! vertebra is_a: UBERON:0003827 ! thoracic segment bone is_a: UBERON:0004247 ! bone of dorsum is_a: UBERON:0015008 ! thoracic vertebra endochondral element intersection_of: UBERON:0015008 ! thoracic vertebra endochondral element intersection_of: RO:0002473 UBERON:0002481 ! composed primarily of bone tissue relationship: RO:0002202 UBERON:0013507 ! develops from thoracic vertebra cartilage element property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/d/d2/Gray90.png" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "thoracic vertebra" xsd:string [Term] id: UBERON:0002348 name: epicardium def: "A region of the serous membrane that forms the innermost layer of the pericardium and the outer surface of the heart." [http://orcid.org/0000-0002-6601-2165] comment: EDITOR_NOTE TODO - check links with UBERON:0002425 visceral serous pericardium. develops from proepicardium. WP:Epicardium -- When considered as a part of the pericardium, it is the inner layer, or visceral pericardium, continuous with the serous layer. subset: human_reference_atlas subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "heart epicardium" EXACT [] synonym: "pericardium visceral mesothelium" RELATED [EMAPA:16589] synonym: "visceral serous pericardium of heart" EXACT [FMA:9461] synonym: "visceral serous pericardium proper" EXACT [FMA:9461] xref: AAO:0010409 xref: EHDAA2:0002202 xref: FMA:9461 xref: galen:Epicardium xref: NCIT:C13164 xref: TAO:0005057 xref: UMLS:C0225968 {source="ncithesaurus:Epicardium"} xref: VHOG:0000119 xref: Wikipedia:Epicardium xref: XAO:0000316 xref: ZFA:0005057 is_a: BFO:0000002 is_a: UBERON:0000481 ! multi-tissue structure relationship: BFO:0000050 UBERON:0000948 {source="multiple"} ! part of heart relationship: BFO:0000050 UBERON:0002425 {source="FMA-inferred"} ! part of visceral serous pericardium relationship: RO:0002202 UBERON:0004160 ! develops from proepicardium relationship: RO:0002371 UBERON:0002349 {source="FMA"} ! attached to myocardium property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "epicardium" xsd:string [Term] id: UBERON:0002349 name: myocardium def: "The middle layer of the heart, comprised mainly of striated cardiac muscle fibers." [ISBN:0-683-40008-8, MP:0005329] comment: EDITOR_NOTE TODO - check 'Myocardum proper' in FMA. We superclass the more generic class for now. FMA has is_a muscle layer - should we add this? ZFA and BTO both have is_a 'cardiac muscle' (tissue?). But in U we also follow FMA and have cardiac muscle tissue of myocardium (there is also Fibrocollagenous connective tissue of myocardium), which would be identical (see issue-10). Note that GO also treats left/right ventricular cardiac muscle tissue synonymous with ventricular myocardium subset: efo_slim subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "cardiac muscle" RELATED [ZFA:0001319] synonym: "heart muscle" RELATED [FMA:9462, ZFA:0001319] synonym: "heart myocardium" EXACT [] synonym: "muscle of heart" EXACT [FMA:9462] xref: AAO:0010410 xref: BSA:0000089 xref: BTO:0000901 xref: CALOHA:TS-0440 xref: EFO:0000819 xref: EHDAA2:0004150 xref: EV:0100022 xref: FMA:9462 xref: GAID:173 xref: galen:Myocardium xref: MA:0000164 xref: MAT:0000453 xref: MESH:D009206 xref: NCIT:C12371 xref: RETIRED_EHDAA2:0001220 xref: SCTID:362012001 xref: TAO:0001319 xref: UMLS:C0027061 {source="ncithesaurus:Myocardium"} xref: VHOG:0000083 xref: Wikipedia:Myocardium xref: XAO:0000065 xref: ZFA:0001319 is_a: UBERON:0005983 ! heart layer is_a: UBERON:0018260 ! layer of muscle tissue intersection_of: UBERON:0005983 ! heart layer intersection_of: RO:0002473 UBERON:0001133 ! composed primarily of cardiac muscle tissue relationship: BFO:0000050 UBERON:0000383 ! part of musculature of body relationship: BFO:0000051 UBERON:0002350 ! has part conducting system of heart relationship: RO:0002473 UBERON:0001133 ! composed primarily of cardiac muscle tissue property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/6/6e/Glanzstreifen.jpg" xsd:anyURI property_value: skos:prefLabel "myocardium" xsd:string [Term] id: UBERON:0002350 name: conducting system of heart def: "The cardiac conduction system consists of specialized cardiomyocytes that regulate the frequency of heart beat[GO]." [GO:0003161] subset: efo_slim subset: pheno_slim subset: vertebrate_core synonym: "cardiac conducting system" EXACT [VHOG:0001271] synonym: "cardiac conduction system" EXACT [] synonym: "cardiac impulse conducting system" EXACT [GO:0003161] synonym: "cardionector" EXACT [] synonym: "central conduction system" RELATED [] synonym: "complexus stimulans cordis" EXACT OMO:0003011 [FMA:9476, FMA:TA] synonym: "heart conduction system" EXACT [GO:0003161] synonym: "impulse conducting system" EXACT [MA:0000094] synonym: "systema conducente cordis" EXACT OMO:0003011 [FMA:9476, FMA:TA] xref: EFO:0003909 xref: EHDAA2:0004185 xref: EMAPA:35428 xref: EV:0100025 xref: FMA:9476 xref: MA:0000094 xref: MESH:D006329 xref: SCTID:281489000 xref: TAO:0005063 xref: VHOG:0001271 xref: ZFA:0005063 is_a: UBERON:0004493 ! cardiac muscle tissue of myocardium is_a: UBERON:0010131 {source="FMA"} ! conducting tissue of heart relationship: BFO:0000051 CL:0002068 {source="FMA"} ! has part Purkinje myocyte relationship: BFO:0000051 CL:0002073 {source="FMA"} ! has part transitional myocyte relationship: BFO:0000051 CL:0002074 {source="FMA"} ! has part myocardial endocrine cell relationship: BFO:0000051 CL:1000409 {source="FMA"} ! has part myocyte of sinoatrial node relationship: BFO:0000051 CL:1000410 {source="FMA"} ! has part myocyte of atrioventricular node relationship: RO:0002433 UBERON:0000948 ! contributes to morphology of heart property_value: IAO:0000116 "EHDAA2 divides the system from the tissue" xsd:string property_value: skos:prefLabel "conducting system of heart" xsd:string [Term] id: UBERON:0002351 name: sinoatrial node def: "The part of the cardiac conduction system that controls the timing of heart muscle contraction. It relays electrical signals to the AV node[GO]. Subdivision of conducting system of heart at the junction of the right atrium and the superior vena cava, around the sinoatrial nodal branch of right coronary artery and is continuous with the internodal tract[FMA]." [GO:0003163, Wikipedia:Sinoatrial_node] comment: WP:Heart states: "The SA node is found in all amniotes but not in more primitive vertebrates. In these animals, the muscles of the heart are relatively continuous and the sinus venosus coordinates the beat which passes in a wave through the remaining chambers. Indeed, since the sinus venosus is incorporated into the right atrium in amniotes, it is likely homologous with the SA node. In teleosts, with their vestigial sinus venosus, the main centre of coordination is, instead, in the atrium.". Note however that ZFA has SA node. subset: human_reference_atlas subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "cardiac pacemaker" EXACT [FMA:9477] synonym: "Koch's node" EXACT [FMA:9477] synonym: "node of Keith-Flack" EXACT [FMA:9477] synonym: "nodus sinuatrialis" EXACT OMO:0003011 [FMA:9477, FMA:TA] synonym: "nodus sinuatrialis" RELATED OMO:0003011 [Wikipedia:Sinoatrial_node] synonym: "SA nodal muscle tissue" EXACT [FMA:9477] synonym: "SA node" EXACT [FMA:9477] synonym: "sinoatrial node" EXACT [FMA:9477] synonym: "sinu-atrial node" EXACT [FMA:9477] synonym: "sinuatrial nodal muscle tissue" EXACT [FMA:9477] synonym: "sinuatrial node" EXACT [FMA:9477] synonym: "sinus node" EXACT [FMA:9477] synonym: "sinus node of Keith and Flack" EXACT [FMA:9477] xref: BTO:0004358 xref: EHDAA2:0004184 xref: EMAPA:35772 xref: FMA:9477 xref: GAID:561 xref: MA:0000097 xref: MESH:D012849 xref: NCIT:C33555 xref: SCTID:277687007 xref: TAO:0005069 xref: UMLS:C0037189 {source="ncithesaurus:Sinoatrial_Node"} xref: Wikipedia:Sinoatrial_node xref: ZFA:0005069 is_a: UBERON:0003379 ! cardiac muscle of right atrium is_a: UBERON:0010131 {source="cjm"} ! conducting tissue of heart relationship: BFO:0000050 UBERON:0002350 {source="ZFA"} ! part of conducting system of heart relationship: RO:0002215 GO:0002027 ! capable of regulation of heart rate relationship: RO:0002216 GO:0060048 ! capable of part of cardiac muscle contraction relationship: RO:0002433 UBERON:0002350 ! contributes to morphology of conducting system of heart property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/d/d2/Sinoatrial_node_low_mag.jpg" xsd:anyURI property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/d/de/Sinoatrial_node_2_low_mag.jpg" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0002352 name: atrioventricular node def: "An area of conducting tissue between the atria and the ventricles of the heart that conducts the normal electrical impulse from the atria to the ventricles." [UBERON:cjm, Wikipedia:Atrioventricular_node] subset: efo_slim subset: human_reference_atlas subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "A-V node" RELATED [EMAPA:35153] synonym: "Aschoff-Tawara node" EXACT [FMA:9478] synonym: "atrio-ventricular node" RELATED [EMAPA:35153] synonym: "atrioventricular nodal muscle tissue" EXACT [FMA:9478] synonym: "atriovetricular node" RELATED [TAO:0005070] synonym: "AV nodal muscle tissue" EXACT [FMA:9478] synonym: "AV node" EXACT [FMA:9478, MA:0000095] synonym: "downstream pacemaker" RELATED [ZFA:0005070] synonym: "node of Tawara" EXACT [FMA:9478] synonym: "nodus atrioventricularis" EXACT OMO:0003011 [FMA:TA] synonym: "nodus atrioventricularis" RELATED OMO:0003011 [Wikipedia:Atrioventricular_node] xref: BTO:0005689 xref: EFO:0000276 xref: EHDAA2:0004183 xref: EMAPA:35153 xref: FMA:9478 xref: GAID:558 xref: MA:0000095 xref: MAT:0000498 xref: MESH:D001283 xref: NCIT:C32161 xref: SCTID:277688002 xref: TAO:0005070 xref: UMLS:C0004247 {source="ncithesaurus:Atrioventricular_Node"} xref: VHOG:0001474 xref: Wikipedia:Atrioventricular_node xref: ZFA:0005070 is_a: UBERON:0004491 ! cardiac muscle tissue of interatrial septum is_a: UBERON:0004493 ! cardiac muscle tissue of myocardium is_a: UBERON:0010131 {source="cjm"} ! conducting tissue of heart relationship: BFO:0000050 UBERON:0002350 ! part of conducting system of heart relationship: RO:0002170 UBERON:0002085 ! connected to interatrial septum relationship: RO:0002170 UBERON:0005979 ! connected to crista terminalis relationship: RO:0002433 UBERON:0002350 ! contributes to morphology of conducting system of heart property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/5/50/ConductionsystemoftheheartwithouttheHeart.png" xsd:anyURI property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/9/92/Gray501.png" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0002353 name: bundle of His def: "A part of the His-Purkinje system that transmits signals from the AV node to the cardiac Purkinje fibers[GO]." [GO:0003166, GOC:mtg_heart] subset: human_reference_atlas subset: pheno_slim subset: uberon_slim synonym: "A-V bundle" RELATED [EMAPA:35152] synonym: "atrio-ventricular bundle" EXACT [EMAPA:35152] synonym: "atrioventricular bundle" EXACT [] synonym: "atrioventricular bundle muscle tissue" EXACT [FMA:9484] synonym: "atrioventricular fasciculus" EXACT [FMA:9484] synonym: "AV bundle" EXACT [] synonym: "AVB" EXACT OMO:0003000 [] synonym: "bundle of His" EXACT [FMA:9484, GO:0003166] synonym: "fasciculus atrioventricularis" EXACT OMO:0003011 [Wikipedia:Bundle_of_His] synonym: "His bundle" EXACT [] xref: EMAPA:35152 xref: FMA:9484 xref: GAID:559 xref: galen:BundleOfHis xref: MA:0002576 xref: MESH:D002036 xref: NCIT:C32160 xref: SCTID:362022007 xref: UMLS:C0006382 {source="ncithesaurus:Atrioventricular_Bundle"} xref: Wikipedia:Bundle_of_His is_a: UBERON:0010131 {source="cjm"} ! conducting tissue of heart is_a: UBERON:0018649 ! cardiac muscle tissue of ventricle relationship: BFO:0000050 UBERON:0004146 {source="GO"} ! part of His-Purkinje system relationship: BFO:0000051 CL:1000410 {source="FMA"} ! has part myocyte of atrioventricular node relationship: RO:0002433 UBERON:0002350 ! contributes to morphology of conducting system of heart property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/5/50/ConductionsystemoftheheartwithouttheHeart.png" xsd:anyURI property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/b/b6/ECG_Principle_fast.gif" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0002354 name: cardiac Purkinje fiber def: "The cardiac Purkinje fiber is part of the cardiac conduction system that receives signals from the bundle of His and innervates the ventricular cardiac muscle." [GO:0003165] subset: pheno_slim subset: uberon_slim synonym: "cardiac Purkinje fiber" EXACT [BTO:0001735, GO:0003165] synonym: "heart Purkinje fiber" RELATED [BTO:0001735] synonym: "myofibra conducens cardiacus" EXACT OMO:0003011 [] synonym: "Purkinje fiber" EXACT [FMA:9492, MA:0000096] synonym: "subendocardial branch" EXACT [Wikipedia:Purkinje_fiber] xref: BTO:0001735 xref: EMAPA:35718 xref: FMA:9492 xref: GAID:560 xref: MA:0000096 xref: MESH:D011690 xref: NCIT:C33430 xref: UMLS:C0034144 {source="ncithesaurus:Purkinje_Fiber"} xref: Wikipedia:Purkinje_fiber is_a: UBERON:0010131 {source="FMA"} ! conducting tissue of heart is_a: UBERON:0018649 ! cardiac muscle tissue of ventricle relationship: BFO:0000050 UBERON:8000009 {source="https://github.com/obophenotype/uberon/issues/1785", source="https://orcid.org/0000-0001-5208-3432", source="https://orcid.org/0000-0002-9791-0064"} ! part of Purkinje fiber network relationship: BFO:0000051 CL:0002068 {source="FMA"} ! has part Purkinje myocyte relationship: RO:0002433 UBERON:0002350 ! contributes to morphology of conducting system of heart property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/9/96/Gray498.png" xsd:anyURI [Term] id: UBERON:0002355 name: pelvic region of trunk def: "The lower segment of the trunk, inferioposterior to the abdomen proper, in the transition area between the trunk and the lower limbs." [http://orcid.org/0000-0002-6601-2165, https://github.com/obophenotype/uberon/issues/720, Wikipedia:Pelvis] subset: efo_slim subset: pheno_slim subset: uberon_slim synonym: "lesser pelvis" EXACT [FMA:9578] synonym: "pelvic region" EXACT [] synonym: "pelvis" EXACT [FMA:9578, MA:0000030] synonym: "pelvis region" EXACT [] synonym: "true pelvis" EXACT [FMA:9578] xref: BTO:0001006 xref: CALOHA:TS-2227 xref: EFO:0002805 xref: EMAPA:35931 xref: EV:0100012 xref: FMA:9578 xref: GAID:87 xref: galen:Pelvis xref: MA:0000030 xref: MESH:D010388 xref: NCIT:C12767 xref: SCTID:229765004 xref: UMLS:C0030797 {source="ncithesaurus:Pelvis"} xref: Wikipedia:Pelvis is_a: BFO:0000002 is_a: UBERON:0000475 ! organism subdivision relationship: BFO:0000050 UBERON:0002417 ! part of abdominal segment of trunk relationship: BFO:0000051 UBERON:0007832 ! has part pelvic girdle skeleton [Term] id: UBERON:0002357 name: serous pericardium def: "Serous membrane which is divided into parietal and visceral serous pericardium." [http://orcid.org/0000-0002-6601-2165, Wikipedia:Serous_pericardium] subset: uberon_slim synonym: "pericardium serosum" RELATED OMO:0003011 [Wikipedia:Serous_pericardium] synonym: "serous portion of pericardium" EXACT [FMA:9582] xref: EMAPA:19030 xref: FMA:9582 xref: MA:0002739 xref: SCTID:243954002 xref: Wikipedia:Serous_pericardium is_a: UBERON:0000042 ! serous membrane relationship: BFO:0000050 UBERON:0002406 {source="FMA"} ! part of pericardial sac relationship: BFO:0000051 UBERON:0002408 ! has part parietal serous pericardium relationship: BFO:0000051 UBERON:0002425 ! has part visceral serous pericardium relationship: RO:0002371 UBERON:0002359 {source="FMA"} ! attached to fibrous pericardium property_value: skos:prefLabel "serous pericardium" xsd:string [Term] id: UBERON:0002358 name: peritoneum def: "A serous membrane that lines the peritoneal cavity[VHOG,modified]." [VHOG:0001257] subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "peritonaeum" RELATED [VHOG:0001257] xref: AAO:0010814 xref: BTO:0001472 xref: CALOHA:TS-2072 xref: EV:0100087 xref: FMA:9584 xref: GAID:18 xref: galen:Peritoneum xref: MA:0000449 xref: MESH:D010537 xref: NCIT:C12770 xref: TAO:0005120 xref: UMLS:C0031153 {source="ncithesaurus:Peritoneum"} xref: VHOG:0001257 xref: Wikipedia:Peritoneum xref: XAO:0000139 xref: ZFA:0005120 is_a: UBERON:0000042 ! serous membrane intersection_of: UBERON:0000042 ! serous membrane intersection_of: BFO:0000050 UBERON:0035820 ! part of peritoneal sac relationship: BFO:0000050 UBERON:0003697 {source="MP"} ! part of abdominal wall relationship: BFO:0000050 UBERON:0035820 ! part of peritoneal sac property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/5/5f/Gray1040.png" xsd:anyURI property_value: IAO:0000116 "TODO - in ZFA is_a epithelium" xsd:string property_value: skos:prefLabel "peritoneum" xsd:string [Term] id: UBERON:0002359 name: fibrous pericardium def: "Membrane organ which is attached to the pericardial sac proper and the central tendon of diaphragm and is continuous with the pretracheal fascia.[FMA]." [FMA:9586] subset: organ_slim subset: uberon_slim synonym: "fibrous portion of pericardium" EXACT [] synonym: "pericardium fibrosum" RELATED OMO:0003011 [Wikipedia:Fibrous_pericardium] xref: EMAPA:19029 xref: FMA:9586 xref: MA:0002738 xref: SCTID:243953008 xref: Wikipedia:Fibrous_pericardium is_a: BFO:0000002 is_a: UBERON:0000094 {source="FMA"} ! membrane organ is_a: UBERON:0005181 ! thoracic segment organ relationship: BFO:0000050 UBERON:0002407 {source="FMA"} ! part of pericardium relationship: RO:0002150 UBERON:0002408 ! continuous with parietal serous pericardium relationship: RO:0002473 UBERON:0006815 {source="WP"} ! composed primarily of areolar connective tissue property_value: skos:prefLabel "fibrous pericardium" xsd:string [Term] id: UBERON:0002360 name: meninx def: "Membrane organ that surrounds the brain and the spinal cord." [FMA:9589, http://www.shsu.edu/~bio_mlt/Chap15.html, Wikipedia:Meninx] subset: efo_slim subset: organ_slim subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "layer of meninges" EXACT [] synonym: "meningeal layer" EXACT [] synonym: "meninx primitiva" NARROW [VHOG:0001295] xref: BTO:0000144 xref: CALOHA:TS-1177 xref: EFO:0000867 xref: EMAPA:32660 xref: FMA:9589 xref: GAID:687 xref: MA:0001113 xref: MAT:0000113 xref: MESH:D008578 xref: NCIT:C12348 xref: NLXANAT:090204 xref: TAO:0001355 xref: UMLS:C0025285 {source="ncithesaurus:Meninges"} xref: VHOG:0001295 xref: Wikipedia:Meninx xref: ZFA:0001355 is_a: UBERON:0000094 {source="FMA"} ! membrane organ is_a: UBERON:0004121 ! ectoderm-derived structure relationship: BFO:0000050 UBERON:0010743 ! part of meningeal cluster relationship: RO:0002495 UBERON:0007645 {source="Bgee:AN"} ! immediate transformation of future meninx property_value: foaf:depiction "https://upload.wikimedia.org/wikipedia/commons/4/48/Illu_meninges.jpg" xsd:anyURI property_value: skos:prefLabel "meninx" xsd:string [Term] id: UBERON:0002361 name: pia mater def: "The innermost layer of the leptomeninges, consisting of a delicate membrane closely covering the surface of the brain and spinal cord,and lying under the arachnoid membrane. The pia, unlike the arachnoid, extends into the sulci in gyrencephalic animals." [NLXANAT:090209] subset: pheno_slim subset: uberon_slim synonym: "pia" RELATED [NLXANAT:090209] synonym: "pia mater of neuraxis" EXACT [] synonym: "pial membrane" EXACT [NLXANAT:090209] xref: BTO:0001635 xref: EHDAA2:0004318 xref: EHDAA:1367 xref: EHDAA:1961 xref: EHDAA:2001 xref: EHDAA:2099 xref: EHDAA:2685 xref: EHDAA:2833 xref: EHDAA:2867 xref: EHDAA:3692 xref: EHDAA:3710 xref: EHDAA:6566 xref: EHDAA:6583 xref: EMAPA:32663 xref: FMA:9590 xref: GAID:693 xref: MA:0001116 xref: MESH:D010841 xref: NCIT:C33321 xref: neuronames:1463 xref: NLXANAT:090209 xref: RETIRED_EHDAA2:0001464 xref: SCTID:362305004 xref: UMLS:C0031869 {source="ncithesaurus:Pia_Mater"} xref: Wikipedia:Pia_mater is_a: UBERON:0000391 ! leptomeninx relationship: RO:0002162 NCBITaxon:40674 ! in taxon Mammalia relationship: RO:0002473 UBERON:0011825 ! composed primarily of loose connective tissue property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/3/31/Gray770-en.svg" xsd:anyURI property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/6/65/Gray770.png" xsd:anyURI property_value: IAO:0000116 "consider adding adjacency relationship to neuraxis (brain+spinal cord); however note that at this time the meninges may be considered part of the nervous system" xsd:string property_value: skos:prefLabel "pia mater" xsd:string [Term] id: UBERON:0002362 name: arachnoid mater def: "A think avascular meningeal layer, between the pia mater and the dural mater. It is separated from the pia mater by the subarachnoid space." [ISBN:0471888893, Wikipedia:Arachnoid_mater] subset: pheno_slim subset: uberon_slim synonym: "arachnoid" EXACT [] synonym: "arachnoid mater of neuraxis" EXACT [] synonym: "arachnoid membrane" EXACT [NLXANAT:090208] synonym: "arachnoidea mater" RELATED [BTO:0001636] xref: BTO:0001636 xref: CALOHA:TS-0052 xref: EMAPA:32659 xref: EV:0100314 xref: FMA:9591 xref: GAID:688 xref: MA:0001114 xref: MESH:D001099 xref: NCIT:C32136 xref: neuronames:1464 xref: NLXANAT:090208 xref: SCTID:362304000 xref: UMLS:C1510935 {source="ncithesaurus:Arachnoid_Membrane"} xref: Wikipedia:Arachnoid_mater is_a: UBERON:0000391 ! leptomeninx relationship: RO:0002162 NCBITaxon:40674 {source="ISBN:0073040584"} ! in taxon Mammalia relationship: RO:0002473 GO:0071953 ! composed primarily of elastic fiber property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/a/a0/Gray767.png" xsd:anyURI property_value: skos:prefLabel "arachnoid mater" xsd:string [Term] id: UBERON:0002363 name: dura mater def: "Thick, fibrous meningeal covering surrounding the brain and spinal cord. It is the outermost of the three meningeal coverings. It consists of two layers: the periosteal dura linking the inner surface of the skull and the meningeal dura that lies above the arachnoid dural membrane. The meningeal layer draws away from the periosteal layer and certain locations to form the dural reflections." [NLXANAT:090206] subset: organ_slim subset: pheno_slim subset: uberon_slim synonym: "dura" RELATED [BTO:0001637] synonym: "dura mater of neuraxis" EXACT [] synonym: "pachymeninges" EXACT [NLXANAT:090206] xref: BTO:0001637 xref: CALOHA:TS-2008 xref: EMAPA:32664 xref: FMA:9592 xref: GAID:691 xref: MA:0001115 xref: MESH:D004388 xref: NCIT:C32488 xref: neuronames:1462 xref: NLXANAT:090206 xref: SCTID:362301008 xref: UMLS:C0013313 {source="ncithesaurus:Dura_Mater"} xref: Wikipedia:Dura_mater is_a: UBERON:0002360 ! meninx relationship: RO:0002150 UBERON:0001773 {source="PMID:16496288"} ! continuous with sclera relationship: RO:0002495 UBERON:0007647 {evidence="definitional"} ! immediate transformation of ectomeninx property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/8/8e/Meninges-en.svg" xsd:anyURI property_value: RO:0002161 NCBITaxon:32443 {source="ISBN:0073040584"} property_value: skos:prefLabel "dura mater" xsd:string [Term] id: UBERON:0002364 name: tympanic membrane def: "A thin membrane that separates the external ear from the middle ear, consisting of two epithelia (one part of the the external accoustic meatus epithelium, the other part of the tympanic cavity epithelium) with a fibrous layer between them. Its function is to transmit sound from the air to the ossicles inside the middle ear. The malleus bone bridges the gap between the eardrum and the other ossicles. Rupture or perforation of the eardrum can lead to conductive hearing loss. [WP,unvetted]." [PMID:11237469, Wikipedia:Tympanic_membrane] subset: organ_slim subset: pheno_slim subset: uberon_slim synonym: "ear drum" EXACT [] synonym: "eardrum" EXACT [] synonym: "lateral wall of tympanic cavity" EXACT [] synonym: "membranous wall of tympanic cavity" EXACT [] synonym: "myrinx" EXACT [] synonym: "paries membranaceus cavi tympani" EXACT OMO:0003011 [FMA:9595, FMA:TA] synonym: "Rivinus' membrane" EXACT [] synonym: "tympanum" RELATED [Wikipedia:Tympanic_membrane] xref: EMAPA:19062 xref: FMA:9595 xref: GAID:870 xref: MA:0000257 xref: MESH:D014432 xref: NCIT:C12502 xref: SCTID:181180005 xref: UMLS:C0041445 {source="ncithesaurus:Tympanic_Membrane"} xref: VHOG:0001146 xref: Wikipedia:Tympanic_membrane xref: XAO:0000212 is_a: BFO:0000002 is_a: UBERON:0000094 {source="FMA"} ! membrane organ relationship: BFO:0000050 UBERON:0001756 {source="MA"} ! part of middle ear relationship: BFO:0000051 UBERON:0005042 ! has part inner epithelial layer of tympanic membrane relationship: BFO:0000051 UBERON:0010069 ! has part outer epithelial layer of tympanic membrane relationship: BFO:0000051 UBERON:0010070 ! has part intermediate layer of tympanic membrane relationship: RO:0002202 UBERON:0009213 {source="Wikipedia"} ! develops from pharyngeal membrane of 1st arch relationship: RO:0002220 UBERON:0004114 {source="cjm"} ! adjacent to tympanic cavity relationship: RO:0002433 UBERON:0001756 ! contributes to morphology of middle ear property_value: RO:0002161 NCBITaxon:8459 {source="Wikipedia"} [Term] id: UBERON:0002365 name: exocrine gland def: "A gland that secretes products (excluding hormones and other chemical messengers) into ducts (duct glands) which lead directly into the external environment[WP]. Typical exocrine glands include sweat glands, salivary glands, mammary glands, stomach, liver, pancreas." [Wikipedia:Exocrine_gland] subset: organ_slim subset: pheno_slim subset: uberon_slim synonym: "ducted gland" EXACT [AEO:0000097] synonym: "glandula exocrina" EXACT OMO:0003011 [Wikipedia:Exocrine_gland] xref: AEO:0000097 xref: BTO:0000765 xref: CALOHA:TS-2012 xref: EHDAA2:0003097 xref: EMAPA:35327 xref: FMA:9596 xref: GAID:34 xref: MA:0002564 xref: MESH:D005088 xref: NCIT:C12712 xref: SCTID:115976003 xref: UMLS:C0015282 {source="ncithesaurus:Exocrine_Gland"} xref: Wikipedia:Exocrine_gland is_a: UBERON:0002530 ! gland intersection_of: UBERON:0002530 ! gland intersection_of: BFO:0000050 UBERON:0002330 ! part of exocrine system relationship: BFO:0000050 UBERON:0002330 ! part of exocrine system relationship: BFO:0000051 UBERON:0000058 ! has part duct property_value: IAO:0000116 "Currently this is logically defined by the system it belongs to, but a better system may be base this on presence/absence of ducts. However, the dual nature of the liver should be taken into consideration here. Consider adding subclasses" xsd:string property_value: skos:prefLabel "exocrine gland" xsd:string [Term] id: UBERON:0002367 name: prostate gland def: "The prostate gland is a partly muscular, partly glandular body that is situated near the base of the mammalian male urethra and secretes an alkaline viscid fluid which is a major constituent of the ejaculatory fluid." [GO:0030850, Wikipedia:Prostate] subset: efo_slim subset: human_reference_atlas subset: major_organ subset: organ_slim subset: pheno_slim subset: uberon_slim synonym: "male prostate" EXACT [PMID:10668204] synonym: "prostata" RELATED OMO:0003011 [Wikipedia:Prostate] synonym: "prostate" EXACT [] xref: BTO:0001129 xref: CALOHA:TS-0828 xref: EFO:0000858 xref: EMAPA:19287 xref: EV:0100104 xref: FMA:9600 xref: GAID:392 xref: galen:ProstateGland xref: MA:0000404 xref: MAT:0000078 xref: MESH:D011467 xref: MIAA:0000078 xref: NCIT:C12410 xref: SCTID:181422007 xref: UMLS:C0033572 {source="ncithesaurus:Prostate_Gland"} xref: VHOG:0001261 xref: Wikipedia:Prostate is_a: UBERON:0004119 ! endoderm-derived structure is_a: UBERON:0010147 ! male accessory sex gland relationship: RO:0002202 UBERON:0003820 ! develops from prostate bud property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/a/a1/Prostatelead.jpg" xsd:anyURI property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/prostate-male/v1.2/assets/3d-vh-m-prostate.glb" xsd:anyURI property_value: IAO:0000116 "TODO - FMA treats the gland as part of the prostate - see also FMA:74119." xsd:string property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0002368 name: endocrine gland def: "Endocrine glands are glands of the endocrine system that secrete their products directly into the circulatory system rather than through a duct.[WP, modified]." [Wikipedia:Endocrine_gland] subset: organ_slim subset: pheno_slim subset: uberon_slim synonym: "ductless gland" EXACT [AEO:0000098] synonym: "ductless gland" RELATED [Wikipedia:Ductless_gland] synonym: "glandula endocrina" EXACT [] synonym: "glandulae endocrinae" RELATED OMO:0003011 [Wikipedia:Endocrine_gland] xref: AEO:0000098 xref: BTO:0001488 xref: CALOHA:TS-1300 xref: EHDAA2:0003098 xref: EMAPA:35999 xref: FMA:9602 xref: GAID:335 xref: MA:0002563 xref: MESH:D004702 xref: NCIT:C12704 xref: SCTID:40818001 xref: UMLS:C0014133 {source="ncithesaurus:Endocrine_Gland"} xref: Wikipedia:Endocrine_gland is_a: UBERON:0002530 ! gland intersection_of: UBERON:0002530 ! gland intersection_of: BFO:0000050 UBERON:0000949 ! part of endocrine system relationship: BFO:0000050 UBERON:0000949 ! part of endocrine system relationship: RO:0002215 GO:0046879 ! capable of hormone secretion property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/d/da/Illu_endocrine_system.png" xsd:anyURI property_value: skos:prefLabel "endocrine gland" xsd:string [Term] id: UBERON:0002369 name: adrenal gland def: "Either of a pair of complex endocrine organs near the anterior medial border of the kidney consisting of a mesodermal cortex that produces glucocorticoid, mineralocorticoid, and androgenic hormones and an ectodermal medulla that produces epinephrine and norepinephrine[BTO]." [BTO:0000047, Wikipedia:Adrenal_gland] subset: organ_slim subset: pheno_slim subset: uberon_slim synonym: "adrenal" RELATED [BTO:0000047] synonym: "adrenal capsule" RELATED [BTO:0000047] synonym: "adrenal medulla cell" RELATED [] synonym: "atrabiliary capsule" RELATED [BTO:0000047] synonym: "epinephric gland" RELATED [Wikipedia:Adrenal_gland] synonym: "epinephros" RELATED [BTO:0000047] synonym: "glandula adrenalis" EXACT OMO:0003011 [Wikipedia:Adrenal_gland] synonym: "glandula suprarenalis" EXACT OMO:0003011 [Wikipedia:Adrenal_gland] synonym: "glandula suprarenalis" RELATED [BTO:0000047] synonym: "interrenal gland" RELATED HOMOLOGY [GO:0030325] synonym: "suprarenal capsule" RELATED [BTO:0000047] synonym: "suprarenal gland" RELATED [Wikipedia:Adrenal_gland] xref: AAO:0010551 xref: BTO:0000047 xref: CALOHA:TS-0016 xref: EFO:0000238 xref: EMAPA:18426 xref: EV:0100135 xref: FMA:9604 xref: GAID:446 xref: galen:AdrenalGland xref: MA:0000116 xref: MAT:0000071 xref: MESH:D000311 xref: MIAA:0000071 xref: NCIT:C12666 xref: SCTID:181127006 xref: UMLS:C0001625 {source="ncithesaurus:Adrenal_Gland"} xref: Wikipedia:Adrenal_gland xref: XAO:0000164 is_a: UBERON:0005172 ! abdomen element is_a: UBERON:0006858 ! adrenal/interrenal gland is_a: UBERON:0010314 ! structure with developmental contribution from neural crest is_a: UBERON:0015212 ! lateral structure relationship: BSPO:0000126 UBERON:0000949 {source="FMA-abduced-lr"} ! endocrine system property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/9/9d/Illu_endocrine_system_New.png" xsd:anyURI property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/c/c6/Illu_endocrine_system.jpg" xsd:anyURI [Term] id: UBERON:0002370 name: thymus def: "Anatomical structure of largely lymphoid tissue that functions in cell-mediated immunity by being the site where T cells develop." [NLM:thymus, Wikipedia:Thymus] subset: efo_slim subset: human_reference_atlas subset: major_organ subset: organ_slim subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "thymus gland" EXACT [] synonym: "thymus organ" EXACT [] xref: AAO:0010548 xref: BTO:0001374 xref: CALOHA:TS-1043 xref: EFO:0000860 xref: EHDAA2:0002017 xref: EHDAA:9119 xref: EMAPA:18768 xref: EV:0100138 xref: FMA:9607 xref: GAID:464 xref: MA:0000142 xref: MAT:0000080 xref: MESH:D013950 xref: MIAA:0000080 xref: NCIT:C12433 xref: SCTID:118507000 xref: TAO:0001078 xref: UMLS:C0040113 {source="ncithesaurus:Thymus_Gland"} xref: VHOG:0000253 xref: Wikipedia:Thymus xref: XAO:0000163 xref: ZFA:0001078 is_a: UBERON:0002368 {source="EHDAA2"} ! endocrine gland is_a: UBERON:0004119 ! endoderm-derived structure is_a: UBERON:0004177 ! hemopoietic organ is_a: UBERON:0005057 ! immune organ is_a: UBERON:0005058 ! hemolymphoid system gland relationship: BFO:0000050 UBERON:0000153 ! part of anterior region of body relationship: BFO:0000051 UBERON:0003483 ! has part thymus lymphoid tissue relationship: BFO:0000051 UBERON:0003846 ! has part thymus epithelium relationship: BFO:0000067 GO:0030217 ! contains process T cell differentiation relationship: RO:0002202 UBERON:0005562 {source="ZFA"} ! develops from thymus primordium property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/thymus-female/v1.3/assets/3d-vh-f-thymus.glb" xsd:anyURI property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/thymus-male/v1.3/assets/3d-vh-m-thymus.glb" xsd:anyURI property_value: foaf:depiction "https://upload.wikimedia.org/wikipedia/commons/c/cf/Illu_thymus.jpg" xsd:anyURI property_value: IAO:0000116 "check - a subtype of gland? not in GO. NCIT has thymus and thymus gland. EHDAA2 has ductless gland." xsd:string property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0002371 name: bone marrow def: "The soft tissue that fills the cavities of bones." [MGI:cwg, MP:0002397] subset: efo_slim subset: human_reference_atlas subset: pheno_slim subset: uberon_slim synonym: "medulla of bone" RELATED [BTO:0000141] synonym: "medulla ossea" EXACT OMO:0003011 [BTO:0000141, FMA:9608] synonym: "medulla ossium" EXACT OMO:0003011 [BTO:0000141, Wikipedia:Bone_marrow] synonym: "medullary bone" RELATED [] xref: AAO:0011007 xref: BTO:0000141 xref: BTO:0000829 xref: CALOHA:TS-0087 xref: EFO:0000868 xref: EMAPA:32760 xref: EV:0100046 xref: FMA:9608 xref: GAID:1287 xref: galen:BoneMarrow xref: MA:0000134 xref: MAT:0000084 xref: MESH:D001853 xref: MIAA:0000084 xref: NCIT:C12431 xref: SCTID:421320006 xref: UMLS:C0005953 {source="ncithesaurus:Bone_Marrow"} xref: VHOG:0001218 xref: Wikipedia:Bone_marrow xref: XAO:0000123 is_a: UBERON:0000479 ! tissue intersection_of: UBERON:0000479 ! tissue intersection_of: BFO:0000050 UBERON:0001474 ! part of bone element intersection_of: BFO:0000051 UBERON:0012429 ! has part hematopoietic tissue relationship: BFO:0000050 UBERON:0001474 ! part of bone element relationship: BFO:0000050 UBERON:0002390 {source="FMA", source="MA"} ! part of hematopoietic system relationship: BFO:0000050 UBERON:0002405 ! part of immune system relationship: BFO:0000051 CL:0002092 ! has part bone marrow cell relationship: BFO:0000051 UBERON:0012429 ! has part hematopoietic tissue property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/7/74/Gray72-en.svg" xsd:anyURI property_value: IAO:0000116 "consider placement of NCIT:C53466 medullary bone" xsd:string property_value: IAO:0000116 "TODO - create superclass for bone marrow / head kidney. both are portions of tissue in the hematopoetic system. also consider adding as subclass of zone of bone organ for consistency with FMA. See also: Leydig and epigonal organs" xsd:string property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0002372 name: tonsil def: "Either of the two small almond-shaped masses of lymph tissue found on either side of the oropharynx." [MGI:cwg, MP:0002380] subset: efo_slim subset: human_reference_atlas subset: pheno_slim subset: uberon_slim synonym: "Mandel" RELATED [BTO:0001387] xref: BTO:0001387 xref: CALOHA:TS-1053 xref: EFO:0001401 xref: EMAPA:35871 xref: EV:0100052 xref: FMA:9609 xref: GAID:341 xref: MA:0000143 xref: MESH:D014066 xref: NCIT:C12802 xref: neuronames:671 xref: UMLS:C0836921 {source="ncithesaurus:Tonsil"} xref: UMLS:C1519547 {source="ncithesaurus:Tonsilar_Tissue"} xref: UMLS:C1519548 {source="ncithesaurus:Tonsillar_Lymphoid_Tissue"} xref: VHOG:0001139 xref: Wikipedia:Tonsil is_a: UBERON:0001962 ! gut-associated lymphoid tissue disjoint_from: UBERON:0005351 ! paraflocculus relationship: BFO:0000050 UBERON:0001735 {source="cjm"} ! part of tonsillar ring relationship: RO:0001025 UBERON:0000167 ! located in oral cavity relationship: RO:0002433 UBERON:0001735 ! contributes to morphology of tonsillar ring property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0002374 name: metacarpal bone def: "A bone that is part of the metacarpal skeleton." [https://orcid.org/0000-0002-6601-2165, Wikipedia:Metacarpal_bone] subset: efo_slim subset: pheno_slim subset: uberon_slim synonym: "metacarpal" EXACT [] xref: EFO:0003886 xref: EMAPA:36158 xref: FMA:9612 xref: galen:Metacarpal xref: MA:0000302 xref: NCIT:C12751 xref: SCTID:181977005 xref: SCTID:425761003 xref: UMLS:C0025526 {source="ncithesaurus:Metacarpal_Bone"} xref: Wikipedia:Metacarpal_bone is_a: UBERON:0003607 ! forelimb long bone is_a: UBERON:0003821 {is_inferred="true"} ! metapodium bone is_a: UBERON:0012358 ! manual digitopodium bone is_a: UBERON:0015042 ! manual digit metacarpus endochondral element intersection_of: UBERON:0001474 ! bone element intersection_of: BFO:0000050 UBERON:0004453 ! part of metacarpus region relationship: BFO:0000050 UBERON:0010544 ! part of metacarpus skeleton relationship: RO:0002170 UBERON:0001435 ! connected to carpal bone relationship: RO:0002170 UBERON:0001436 ! connected to phalanx of manus property_value: foaf:depiction "https://upload.wikimedia.org/wikipedia/commons/2/2f/Metacarpals_numbered-en.svg" xsd:anyURI [Term] id: UBERON:0002376 name: cranial muscle def: "Any skeletal muscle that is part of the head region." [http://orcid.org/0000-0002-6601-2165] comment: defined generically so could in theory encompass FBbt:00003260 'skeletal muscle of head', or the muscle of a starfish Aristotle's lantern, but we restrict this to craniates. Skeletal muscles of the head originate from the non-segmented head mesoderm (Noden, 1983; Wachtler et al., 1984) subset: efo_slim subset: human_reference_atlas subset: uberon_slim subset: vertebrate_core synonym: "adult head muscle organ" NARROW [OBOL:automatic] synonym: "cephalic muscle" EXACT [ZFA:0001652] synonym: "cephalic musculature" EXACT [] synonym: "cranial muscle" RELATED [ZFA:0001652] synonym: "head muscle" EXACT [MA:0000578] synonym: "head muscle organ" EXACT [OBOL:automatic] synonym: "head muscles" RELATED [] synonym: "muscle of head" EXACT [FMA:9616] synonym: "muscle organ of adult head" EXACT [OBOL:automatic] synonym: "muscle organ of head" EXACT [OBOL:automatic] synonym: "musculus caput" EXACT [] xref: AAO:0000107 xref: BTO:0000021 xref: EFO:0003524 xref: EHDAA2:0000322 xref: EMAPA:18172 xref: FMA:9616 xref: MA:0000578 xref: SCTID:244718003 xref: ZFA:0001652 is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0010959 ! craniocervical muscle intersection_of: UBERON:0014892 ! skeletal muscle organ, vertebrate intersection_of: BFO:0000050 UBERON:0000033 ! part of head intersection_of: RO:0002371 UBERON:0003129 ! attached to skull relationship: BFO:0000050 UBERON:0004461 {source="https://github.com/obophenotype/uberon/wiki/Inferring-part-of-relationships"} ! part of skeletal musculature of head relationship: RO:0002202 UBERON:0006904 {source="EHDAA2-abduced"} ! develops from head mesenchyme from mesoderm relationship: RO:0002371 UBERON:0003129 ! attached to skull property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "cranial muscle" xsd:string [Term] id: UBERON:0002377 name: muscle of neck def: "Any muscle that is part of the cervical (neck) region." [http://orcid.org/0000-0002-6601-2165] subset: human_reference_atlas subset: pheno_slim subset: uberon_slim synonym: "muscle organ of neck" EXACT [OBOL:automatic] synonym: "muscle organ of neck (volume)" EXACT [OBOL:automatic] synonym: "neck (volume) muscle organ" EXACT [OBOL:automatic] synonym: "neck muscle" EXACT [] synonym: "neck muscle organ" EXACT [OBOL:automatic] xref: FMA:9617 xref: GAID:149 xref: MA:0000587 xref: MESH:D009334 xref: NCIT:C33163 xref: UMLS:C0027532 {source="ncithesaurus:Neck_Muscle"} is_a: UBERON:0010959 ! craniocervical muscle intersection_of: UBERON:0014892 ! skeletal muscle organ, vertebrate intersection_of: BFO:0000050 UBERON:0000974 ! part of neck relationship: BFO:0000050 UBERON:0004465 {source="prolog"} ! part of musculature of neck property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "muscle of neck" xsd:string [Term] id: UBERON:0002378 name: muscle of abdomen def: "Muscle (organ) which is a part of the abdomen. Examples: external oblique, rectus abdominis." [Wikipedia:Abdominal_muscle] subset: human_reference_atlas subset: pheno_slim subset: uberon_slim synonym: "abdomen muscle" EXACT [] synonym: "abdomen muscle organ" EXACT [OBOL:automatic] synonym: "abdominal muscle" EXACT [] synonym: "abdominal wall muscle" EXACT [] synonym: "abdominal wall musculature" RELATED [EMAPA:35103] synonym: "muscle organ of abdomen" EXACT [OBOL:automatic] xref: BTO:0001261 xref: EMAPA:35103 xref: FMA:9620 xref: GAID:89 xref: MA:0000520 xref: MESH:D000009 xref: NCIT:C32040 xref: SCTID:361352008 xref: UMLS:C0000739 {source="ncithesaurus:Abdominal_Muscle"} xref: Wikipedia:Abdominal_muscle is_a: UBERON:0003833 ! abdominal segment muscle is_a: UBERON:0005172 ! abdomen element intersection_of: UBERON:0014892 ! skeletal muscle organ, vertebrate intersection_of: BFO:0000050 UBERON:0000916 ! part of abdomen relationship: BFO:0000050 UBERON:0002343 {source="prolog"} ! part of abdomen musculature relationship: BFO:0000050 UBERON:0003697 ! part of abdominal wall property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "muscle of abdomen" xsd:string [Term] id: UBERON:0002380 name: trapezius muscle def: "A large superficial muscle that extends longitudinally from the occipital bone to the lower thoracic vertebrae and laterally to the spine of the scapula (shoulder blade). Its functions are to move the scapulae and support the arm. The trapezius has three functional regions: the superior region (descending part), which supports the weight of the arm; the intermediate region (transverse part), which retracts the scapulae; and the inferior region (ascending part), which medially rotates and depresses the scapulae. [WP,unvetted]." [Wikipedia:Trapezius_muscle] subset: human_reference_atlas subset: uberon_slim synonym: "musculus trapezius" RELATED OMO:0003011 [Wikipedia:Trapezius_muscle] synonym: "spinotrapezius" RELATED [Wikipedia:Trapezius_muscle] synonym: "trapezius" EXACT [] xref: EMAPA:18183 xref: FMA:9626 xref: MA:0002398 xref: NCIT:C33809 xref: SCTID:181740005 xref: UMLS:C0224361 {source="ncithesaurus:Trapezius_Muscle"} xref: VHOG:0000834 xref: Wikipedia:Trapezius_muscle is_a: UBERON:0001482 ! muscle of shoulder is_a: UBERON:0010313 ! neural crest-derived structure relationship: RO:0002202 UBERON:0010955 ! develops from trapezius pre-muscle mass relationship: RO:0002372 UBERON:0000351 ! has muscle origin nuchal ligament relationship: RO:0002372 UBERON:0001076 ! has muscle origin neural spine relationship: RO:0002373 UBERON:0002497 ! has muscle insertion acromion relationship: RO:0002373 UBERON:0007173 ! has muscle insertion lateral border of scapula relationship: RO:0002568 UBERON:0001112 {source="dbpedia"} ! has muscle antagonist latissimus dorsi muscle relationship: RO:0002568 UBERON:0001125 {source="dbpedia"} ! has muscle antagonist serratus ventralis property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/6/60/Trapezius.png" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0002381 name: pectoralis major def: "The pectoralis major is a thick, fan-shaped muscle, situated at the upper front of the chest wall. It makes up the bulk of the chest muscles in the male and lies under the breast in the female. Underneath the pectoralis major is the pectoralis minor, a thin, triangular muscle. [WP,unvetted]." [Wikipedia:Pectoralis_major_muscle] subset: human_reference_atlas subset: organ_slim subset: pheno_slim subset: uberon_slim synonym: "musculus pectoralis major" RELATED OMO:0003011 [Wikipedia:Pectoralis_major_muscle] synonym: "pectoralis major muscle" EXACT [] synonym: "pectoralis major muscle structure" EXACT [] xref: EHDAA2:0001424 xref: EHDAA:8311 xref: EMAPA:18179 xref: FMA:9627 xref: MA:0002354 xref: NCIT:C33284 xref: SCTID:181624003 xref: UMLS:C0585574 {source="ncithesaurus:Pectoralis_Major"} xref: VHOG:0000895 xref: Wikipedia:Pectoralis_major_muscle is_a: UBERON:0001482 ! muscle of shoulder is_a: UBERON:0001495 {source="FMA"} ! pectoral muscle relationship: BSPO:0000108 UBERON:0001100 ! pectoralis minor relationship: RO:0002005 UBERON:0003726 ! innervated by thoracic nerve relationship: RO:0002372 UBERON:0000975 ! has muscle origin sternum relationship: RO:0002372 UBERON:0001105 ! has muscle origin clavicle bone relationship: RO:0002373 UBERON:0000976 ! has muscle insertion humerus property_value: foaf:depiction "https://upload.wikimedia.org/wikipedia/commons/6/6c/Pectoralis_major.png" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0002384 name: connective tissue def: "Tissue with cells that deposit non-polarized extracellular matrix including connective tissue fibers and ground substance." [GO_REF:0000034, http://dx.plos.org/10.1371/journal.pone.0051070, https://github.com/obophenotype/uberon/issues/23, PSPUB:0000170, VSAO:0000017] subset: human_reference_atlas subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "Bindegewebe" RELATED [BTO:0000421] synonym: "portion of connective tissue" EXACT [FMA:9640] synonym: "textus connectivus" EXACT [] xref: AAO:0000098 xref: BTO:0000421 xref: CALOHA:TS-2009 xref: EFO:0000952 xref: EMAPA:35251 xref: FMA:9640 xref: GAID:100 xref: galen:ConnectiveTissue xref: MA:0000011 xref: MAT:0000301 xref: MESH:D003238 xref: MIAA:0000301 xref: NCIT:C12374 xref: SCTID:361919005 xref: TAO:0001641 xref: UMLS:C0009780 {source="ncithesaurus:Connective_Tissue"} xref: VSAO:0000017 xref: XAO:0001017 xref: ZFA:0001632 is_a: UBERON:0000479 ! tissue relationship: RO:0002162 NCBITaxon:6072 ! in taxon Eumetazoa property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "connective tissue" xsd:string property_value: terms:contributor https://orcid.org/0000-0002-6601-2165 property_value: terms:contributor https://orcid.org/0000-0003-3162-7490 [Term] id: UBERON:0002385 name: muscle tissue def: "Muscle tissue is a contractile tissue made up of actin and myosin fibers[GO]." [GO:0060537, https://sourceforge.net/tracker/index.php?func=detail&aid=2801266&group_id=36855&atid=440764, Wikipedia:Muscle_tissue] comment: Vertebrate muscle is categorized into three major muscle types defined by their structural and functional properties: skeletal, cardiac and smooth. In Dmel the counterparts are somatic, heart/cardiac and visceral. Here we take a cell type based approach. subset: uberon_slim synonym: "muscular tissue" EXACT SENSU [] synonym: "portion of muscle tissue" EXACT [FMA:9641] synonym: "textus muscularis" EXACT [] xref: AAO:0000306 xref: AEO:0000122 xref: CALOHA:TS-0642 xref: EHDAA2:0003122 xref: EMAPA:32715 xref: FMA:9641 xref: galen:MuscleTissue xref: MA:0002437 xref: MESH:D009132 xref: NCIT:C12435 xref: SCTID:91727004 xref: UMLS:C2328219 {source="ncithesaurus:Muscle_Tissue"} xref: Wikipedia:Muscle_tissue is_a: UBERON:0000479 ! tissue is_a: UBERON:0004120 ! mesoderm-derived structure intersection_of: UBERON:0000479 ! tissue intersection_of: RO:0002473 CL:0000187 ! composed primarily of muscle cell disjoint_from: UBERON:0003714 ! neural tissue relationship: BFO:0000050 UBERON:0001015 ! part of musculature relationship: RO:0002215 GO:0006936 ! capable of muscle contraction relationship: RO:0002473 CL:0000187 ! composed primarily of muscle cell property_value: skos:prefLabel "muscle tissue" xsd:string [Term] id: UBERON:0002386 name: forelimb zeugopod def: "The middle limb segment of the pectoral free limb, between the autopod and stylopod segments. Includes as parts the forelimb zeugopodial skeleton, which includes as parts the radius and ulna, or their cartilage precursors, or evolutionary variants." [PHENOSCAPE:curators] subset: efo_slim subset: pheno_slim subset: uberon_slim synonym: "antebrachial region" EXACT [] synonym: "antebrachium" EXACT [VSAO:0005058, Wikipedia:Forearm] synonym: "antebrachium" RELATED OMO:0003011 [Wikipedia:Forearm] synonym: "antibrachium" EXACT [] synonym: "arm middle limb segment" EXACT [OBOL:automatic] synonym: "arm zeugopod" EXACT [OBOL:automatic] synonym: "brachial region middle limb segment" EXACT [OBOL:automatic] synonym: "brachial region zeugopod" EXACT [OBOL:automatic] synonym: "fore epipodium" RELATED [] synonym: "forearm" EXACT [] synonym: "forelimb epipodium" EXACT [] synonym: "forelimb zeugopodium" EXACT [] synonym: "forelimb zygopod" EXACT [] synonym: "intermediate segment of free upper limb" EXACT [] synonym: "lower arm" EXACT HUMAN_PREFERRED [MA:0000034] synonym: "lower segment of arm" EXACT [] synonym: "middle limb segment of arm" EXACT [OBOL:automatic] synonym: "middle limb segment of brachial region" EXACT [OBOL:automatic] synonym: "middle limb segment of forelimb" EXACT [https://orcid.org/0000-0002-6601-2165] synonym: "middle limb segment of proximal segment of free upper limb" EXACT [OBOL:automatic] synonym: "regio antebrachialis" EXACT OMO:0003011 [FMA:9663, FMA:TA] synonym: "wing zeugopod" NARROW SENSU [NCBITaxon:8782, OBOL:automatic] synonym: "zeugopod of arm" EXACT [] synonym: "zeugopod of brachial region" EXACT [OBOL:automatic] synonym: "zeugopod of forelimb" EXACT [] synonym: "zeugopod of proximal segment of free upper limb" EXACT [OBOL:automatic] xref: BTO:0001447 xref: CALOHA:TS-2205 xref: EFO:0003053 xref: EHDAA2:0000553 xref: EHDAA:4172 xref: EHDAA:6218 xref: EMAPA:17417 xref: FMA:9663 xref: GAID:55 xref: galen:Forearm xref: MA:0000034 xref: MESH:D005542 xref: NCIT:C32628 xref: SCTID:362741001 xref: UMLS:C0016536 {source="ncithesaurus:Forearm"} xref: VHOG:0000341 xref: VSAO:0005058 xref: Wikipedia:Forearm is_a: UBERON:0002471 ! zeugopod is_a: UBERON:0008785 ! upper limb segment intersection_of: UBERON:0002471 ! zeugopod intersection_of: BFO:0000050 UBERON:0002102 ! part of forelimb relationship: BFO:0000050 UBERON:0001460 {source="MA"} ! part of arm relationship: RO:0002551 UBERON:0010703 ! has skeleton forelimb zeugopod skeleton property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/3/3b/Veins.jpg" xsd:anyURI property_value: foaf:depiction "https://upload.wikimedia.org/wikipedia/commons/5/50/Forearm_labeled.png" xsd:anyURI [Term] id: UBERON:0002387 name: pes def: "Distal portion of the hind limb, including tarsal region, metatarsal region and digits." [Wikipedia:Foot, Wikipedia:Pes_(anatomy)] subset: efo_slim subset: pheno_slim subset: uberon_slim synonym: "foot" EXACT HUMAN_PREFERRED [MA:0000044] synonym: "hind foot" NARROW [] synonym: "hind limb autopodium" RELATED [VHOG:0000350] synonym: "hind paw" NARROW SENSU [EMAPA:17428, OBOL:automatic] synonym: "hind-paw" NARROW SENSU [EMAPA:17428] synonym: "hindfeet" NARROW OMO:0003004 [] synonym: "hindfoot" NARROW [] synonym: "hindfoot of quadruped" NARROW [] synonym: "hindlimb autopod" EXACT [OBOL:automatic] synonym: "hindlimb autopodium" EXACT [OBOL:automatic] synonym: "hindlimb distal free limb segment" EXACT [OBOL:automatic] synonym: "hindpaw" NARROW SENSU [MA:0000044] synonym: "pes" EXACT [https://orcid.org/0000-0002-6601-2165] synonym: "terminal segment of free lower limb" EXACT [] xref: BTO:0000476 xref: CALOHA:TS-0377 xref: EFO:0003065 xref: EHDAA2:0000546 xref: EMAPA:17459 xref: FMA:9664 xref: GAID:40 xref: galen:Foot xref: MA:0000044 xref: MESH:D005528 xref: NCIT:C32622 xref: SCTID:302545001 xref: UMLS:C0016504 {source="ncithesaurus:Foot"} xref: VHOG:0000350 xref: Wikipedia:Pes_(anatomy) is_a: UBERON:0002470 ! autopod region is_a: UBERON:0008784 ! lower limb segment intersection_of: UBERON:0002470 ! autopod region intersection_of: BFO:0000050 UBERON:0002103 ! part of hindlimb relationship: RO:0002202 UBERON:0006871 ! develops from embryonic footplate relationship: RO:0002551 UBERON:0001445 ! has skeleton skeleton of pes property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/a/ae/Male_Right_Foot_1.jpg" xsd:anyURI [Term] id: UBERON:0002389 name: manual digit def: "A digit that is part of a manus (hand)." [http://orcid.org/0000-0002-6601-2165] subset: pheno_slim subset: uberon_slim synonym: "digit of hand" EXACT [FMA:9666] synonym: "digit of manus" EXACT [] synonym: "digitus manus" EXACT [] synonym: "finger" EXACT [FMA:9666] synonym: "fore digit" EXACT [AAO:0000857, XAO:0003036] synonym: "forelimb digit" EXACT [] synonym: "hand digit" EXACT [MA:0000041] synonym: "manual digit (phalangeal portion) plus soft tissue" EXACT COMPARATIVE_PREFERRED [http://orcid.org/0000-0002-6601-2165] xref: AAO:0000857 xref: BTO:0004669 xref: EHDAA2:0000404 xref: EMAPA:32642 xref: FMA:9666 xref: GAID:57 xref: galen:Finger xref: MA:0000041 xref: MESH:D005385 xref: NCIT:C32608 xref: NLXANAT:20090602 xref: SCTID:283992002 xref: UMLS:C0016129 {source="ncithesaurus:Finger"} xref: Wikipedia:Finger xref: XAO:0003036 is_a: UBERON:0002544 ! digit intersection_of: UBERON:0002544 ! digit intersection_of: BFO:0000050 UBERON:0002102 ! part of forelimb relationship: BFO:0000050 UBERON:0012141 {source="PHENOSCAPE:ni"} ! part of manual digitopodium region relationship: BFO:0000050 UBERON:5002389 ! part of manual digit plus metapodial segment [Term] id: UBERON:0002390 name: hematopoietic system def: "Anatomical system that is involved in the production of hematopoietic cells." [Wikipedia:Haematopoiesis] subset: efo_slim subset: human_reference_atlas subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "Blutbildungssystem" RELATED [BTO:0000570] synonym: "haematological system" EXACT [] synonym: "haematopoietic system" RELATED [] synonym: "haemopoietic system" EXACT [] synonym: "hematological system" RELATED [] synonym: "hematolymphoid system" RELATED [] synonym: "hemopoietic system" RELATED [] synonym: "organa haemopoietica" EXACT [] xref: AAO:0011002 xref: BTO:0000570 xref: CALOHA:TS-0449 xref: EFO:0000798 xref: EMAPA:35402 xref: EV:0100045 xref: FMA:9667 xref: GAID:1008 xref: MA:0002434 xref: MAT:0000022 xref: MESH:D006413 xref: MIAA:0000022 xref: NCIT:C12909 xref: SCTID:362587009 xref: TAO:0005023 xref: UMLS:C0018957 {source="ncithesaurus:Hematopoietic_System"} xref: VHOG:0001624 xref: Wikipedia:Haematopoiesis xref: XAO:0000122 xref: ZFA:0005023 is_a: UBERON:0000467 ! anatomical system is_a: UBERON:0004120 ! mesoderm-derived structure disjoint_from: UBERON:0002405 ! immune system disjoint_from: UBERON:0002416 ! integumental system disjoint_from: UBERON:0002423 ! hepatobiliary system disjoint_from: UBERON:0004456 ! entire sense organ system disjoint_from: UBERON:8450002 ! excretory system relationship: BFO:0000050 UBERON:0002193 {source="FMA"} ! part of hemolymphoid system relationship: RO:0002202 UBERON:0003061 {evidence="definitional"} ! develops from blood island property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "hematopoietic system" xsd:string [Term] id: UBERON:0002391 name: lymph def: "Lymph is the fluid that is formed when interstitial fluid enters the conduits of the lymphatic system through lymph capillaries[WP]." [Wikipedia:Lymph] subset: efo_slim subset: pheno_slim subset: uberon_slim synonym: "lympha" RELATED OMO:0003011 [Wikipedia:Lymph] xref: BTO:0000855 xref: CALOHA:TS-0580 xref: EFO:0000871 xref: ENVO:02000041 xref: EV:0100049 xref: FMA:9671 xref: GAID:1186 xref: galen:Lymph xref: MA:0002520 xref: MAT:0000055 xref: MESH:D008196 xref: MIAA:0000055 xref: NCIT:C13252 xref: UMLS:C0024202 {source="ncithesaurus:Lymph"} xref: VHOG:0001590 xref: Wikipedia:Lymph xref: ZFA:0005658 is_a: BFO:0000002 is_a: UBERON:0000179 ! haemolymphatic fluid relationship: BFO:0000050 UBERON:0006558 ! part of lymphatic part of lymphoid system relationship: RO:0002494 UBERON:0000913 ! transformation of interstitial fluid property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/1/19/Illu_lymph_capillary.png" xsd:anyURI [Term] id: UBERON:0002392 name: nasolacrimal duct def: "The paired channels leading from the lacrimal sacs to the inferior meatus of the nose, through which tears are conducted through the nasal cavity." [ISBN:0-683-40008-8, MP:0008969] subset: pheno_slim subset: uberon_slim synonym: "d. nasolacrimalis" RELATED OMO:0003011 [Wikipedia:Nasolacrimal_duct] synonym: "lacrimal duct" RELATED [PMID:30285382] synonym: "nasolacrimal duct - posterior naris" BROAD [VHOG:0000664] synonym: "tear duct" RELATED [Wikipedia:Nasolacrimal_duct] xref: AAO:0000643 xref: EHDAA2:0001237 xref: EHDAA:7849 xref: EHDAA:9094 xref: EMAPA:17853 xref: FMA:9703 xref: GAID:902 xref: MA:0001299 xref: MESH:D009301 xref: NCIT:C33161 xref: SCTID:280643009 xref: UMLS:C0027437 {source="ncithesaurus:Nasolacrimal_Duct"} xref: VHOG:0000664 xref: Wikipedia:Nasolacrimal_duct is_a: BFO:0000002 is_a: UBERON:0000025 ! tube is_a: UBERON:0000058 ! duct relationship: BFO:0000050 UBERON:0001850 ! part of lacrimal drainage system relationship: BFO:0000051 CL:0000160 ! has part goblet cell relationship: BFO:0000051 UBERON:0007602 ! has part stratified columnar epithelium relationship: channel_for UBERON:0001827 ! secretion of lacrimal gland relationship: RO:0002176 UBERON:0001351 ! connects lacrimal sac relationship: RO:0002176 UBERON:0001707 ! connects nasal cavity relationship: RO:0002202 UBERON:0006266 ! develops from nasolacrimal groove relationship: RO:0002433 UBERON:0001750 ! contributes to morphology of lacrimal apparatus property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/c/cf/Gray896.png" xsd:anyURI [Term] id: UBERON:0002393 name: pharyngotympanic tube def: "Organ with organ cavity which connects the cavity of the middle ear to the cavity of the pharynx. Examples: There are only two pharyngotympanic tubes, the right and the left pharyngotympanic tubes.[FMA]." [FMA:FMA, Wikipedia:Eustachian_tube] comment: EDITOR_NOTE we follow FMA in making this an organ, but include a separate class for the part that is epithelium, which is equivalent to the EHDAA2 structure. From this we infer the developmental relationship subset: organ_slim subset: pheno_slim subset: uberon_slim synonym: "auditory tube" EXACT [MA:0000255] synonym: "eustachian tube" RELATED [] synonym: "internal auditory tube" EXACT [] synonym: "pharyngo-tympanic tube" EXACT [MA:0000255] synonym: "tuba auditiva" EXACT OMO:0003011 [FMA:9705, FMA:TA] synonym: "tuba auditiva; tuba auditoria; tuba auditivea" RELATED OMO:0003011 [Wikipedia:Eustachian_tube] synonym: "tuba auditoria" EXACT OMO:0003011 [FMA:9705, FMA:TA] synonym: "tuba pharyngotympanica" RELATED OMO:0003011 [] xref: AAO:0000146 xref: AAO:0011016 xref: EMAPA:17601 xref: EV:0100359 xref: FMA:9705 xref: GAID:869 xref: MA:0000255 xref: MESH:D005064 {sssom:mapping_justification="https://w3id.org/semapv/vocab/LexicalMatching"} xref: NCIT:C12500 xref: UMLS:C0015183 {source="ncithesaurus:Eustachian_Tube"} xref: VHOG:0001145 xref: Wikipedia:Eustachian_tube xref: XAO:0000213 is_a: BFO:0000002 is_a: UBERON:0000062 {source="FMA"} ! organ relationship: BFO:0000050 UBERON:0001756 ! part of middle ear relationship: BFO:0000051 UBERON:0010062 ! has part pharyngotympanic tube epithelium property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/4/40/Ear-anatomy-text-small-en.svg" xsd:anyURI [Term] id: UBERON:0002394 name: bile duct def: "Any of the ducts that form the biliary tree, carrying bile from the liver to the small intestine." [http://orcid.org/0000-0002-6601-2165, Wikipedia:Bile_duct] subset: human_reference_atlas subset: pheno_slim subset: uberon_slim synonym: "bile tube" RELATED [] synonym: "biliary duct" RELATED [FMA:9706] synonym: "gall duct" RELATED [BTO:0000122] synonym: "hepatic duct" RELATED INCONSISTENT [ZFA:0001100] xref: AAO:0011019 xref: BTO:0000122 xref: CALOHA:TS-0075 xref: EMAPA:35171 xref: EV:0100091 xref: FMA:9706 xref: GAID:280 xref: MA:0000354 xref: MESH:D001652 xref: NCIT:C12376 xref: SCTID:276157007 xref: TAO:0001100 xref: UMLS:C0005400 {source="ncithesaurus:Bile_Duct"} xref: VHOG:0000212 xref: Wikipedia:Bile_duct xref: XAO:0000134 xref: ZFA:0001100 is_a: UBERON:0000025 ! tube is_a: UBERON:0003928 ! digestive system duct is_a: UBERON:0004119 ! endoderm-derived structure intersection_of: UBERON:0000058 ! duct intersection_of: BFO:0000050 UBERON:0001173 ! part of biliary tree relationship: BFO:0000050 UBERON:0001173 {source="EMAPA", source="MA"} ! part of biliary tree relationship: channel_for UBERON:0001970 ! bile relationship: RO:0002202 UBERON:0008835 {source="XAO"} ! develops from hepatic diverticulum relationship: RO:0002433 UBERON:0001173 ! contributes to morphology of biliary tree property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/5/5d/Digestive_system_showing_bile_duct.png" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "bile duct" xsd:string [Term] id: UBERON:0002396 name: vomer def: "The triangular flat bone of the nasal septum." [ISBN:0-683-40008-8, MP:0000098] subset: human_reference_atlas subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "prevomer" RELATED [TAO:0000308] synonym: "vomer bone" EXACT [] xref: AAO:0000633 xref: FMA:9710 xref: MA:0001496 xref: NCIT:C33888 xref: SCTID:272678009 xref: TAO:0000308 xref: UMLS:C0242403 {source="ncithesaurus:Vomer"} xref: Wikipedia:Vomer xref: ZFA:0000308 is_a: UBERON:0008001 {source="FMA"} ! irregular bone is_a: UBERON:0011597 ! bone of upper jaw is_a: UBERON:0012071 ! palate bone relationship: BFO:0000050 UBERON:0011085 ! part of palatoquadrate arch relationship: RO:0002433 UBERON:0011156 ! contributes to morphology of facial skeleton property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/7/77/Illu_facial_bones.jpg" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "vomer" xsd:string [Term] id: UBERON:0002398 name: manus def: "Distal segment of the fore limb, including carpal region, metacarpal region and digits." [Wikipedia:Hand, Wikipedia:Manus_(anatomy)] subset: pheno_slim subset: uberon_slim synonym: "fore foot" NARROW INCONSISTENT [] synonym: "fore paw" NARROW SENSU [EMAPA:17428, OBOL:automatic] synonym: "fore-paw" NARROW SENSU [EMAPA:17428] synonym: "forefeet" NARROW OMO:0003004 [] synonym: "forefoot" NARROW INCONSISTENT [] synonym: "forefoot of quadruped" NARROW [] synonym: "forelimb autopod" EXACT [OBOL:automatic] synonym: "forelimb autopodium" EXACT [OBOL:automatic] synonym: "forepaw" NARROW SENSU [MA:0000037] synonym: "hand" EXACT HUMAN_PREFERRED [MA:0000037] synonym: "hand region" EXACT [EHDAA2:0000728] synonym: "terminal segment of free upper limb" EXACT [] xref: AAO:0010803 xref: BTO:0004668 xref: CALOHA:TS-2213 xref: EHDAA2:0000728 xref: EMAPA:17428 xref: FMA:9712 xref: GAID:56 xref: galen:Hand xref: MA:0000037 xref: MESH:D006225 xref: NCIT:C32712 xref: NLXANAT:20090603 xref: SCTID:302539009 xref: UMLS:C0018563 {source="ncithesaurus:Hand"} xref: VHOG:0000344 xref: Wikipedia:Manus_(anatomy) is_a: UBERON:0002470 ! autopod region is_a: UBERON:0008785 ! upper limb segment intersection_of: UBERON:0002470 ! autopod region intersection_of: BFO:0000050 UBERON:0002102 ! part of forelimb relationship: RO:0002202 UBERON:0006875 ! develops from embryonic handplate relationship: RO:0002551 UBERON:0001442 ! has skeleton skeleton of manus property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/7/76/LeftHand0.jpg" xsd:anyURI [Term] id: UBERON:0002400 name: parietal pleura def: "The outer serous membrane of the pulmonary pleural." [UBERON:cjm, Wikipedia:Pulmonary_pleurae] comment: the part of the pleura external to the visceral pleura. It lines the inner surface of the chest wall, covers the diaphragm, and is reflected over the structures occupying the middle of the thorax subset: pheno_slim subset: uberon_slim synonym: "pleura parietalis" RELATED OMO:0003011 [Wikipedia:Parietal_pleura] xref: EMAPA:16776 xref: FMA:9733 xref: MA:0002488 xref: NCIT:C33273 xref: SCTID:361998003 xref: UMLS:C0225777 {source="ncithesaurus:Parietal_Pleura"} xref: VHOG:0001495 xref: Wikipedia:Parietal_pleura is_a: UBERON:0004923 ! organ component layer intersection_of: UBERON:0004923 ! organ component layer intersection_of: BFO:0000050 UBERON:0000977 ! part of pleura intersection_of: RO:0002220 UBERON:0002224 ! adjacent to thoracic cavity relationship: BFO:0000050 UBERON:0000977 ! part of pleura relationship: RO:0002005 UBERON:0003727 ! innervated by intercostal nerve relationship: RO:0002220 UBERON:0002224 ! adjacent to thoracic cavity relationship: RO:0002433 UBERON:0000977 ! contributes to morphology of pleura property_value: skos:prefLabel "parietal pleura" xsd:string [Term] id: UBERON:0002401 name: visceral pleura def: "The inner serous membrane of the pulmonary pleural. The visceral pleura lines the lungs." [UBERON:cjm, Wikipedia:Pulmonary_pleurae] subset: human_reference_atlas subset: pheno_slim subset: uberon_slim synonym: "lung mesothelium" RELATED [EHDAA2:0002205] synonym: "lung pleura" RELATED [] synonym: "pleura pulmonalis" EXACT OMO:0003011 [FMA:9734, FMA:TA] synonym: "pleura visceralis" EXACT OMO:0003011 [Wikipedia:Visceral_pleura] synonym: "pleura visceralis (pulmonalis)" EXACT [] synonym: "pulmonary pleura" RELATED INCONSISTENT [FMA:9734] synonym: "pulmonary visceral pleura" EXACT [] xref: EHDAA2:0002205 xref: EMAPA:16777 xref: FMA:9734 xref: MA:0002489 xref: NCIT:C33881 xref: SCTID:361997008 xref: UMLS:C0225776 {source="ncithesaurus:Visceral_Pleura"} xref: VHOG:0001496 is_a: UBERON:0022350 ! visceral serous membrane intersection_of: UBERON:0004923 ! organ component layer intersection_of: BFO:0000050 UBERON:0000977 ! part of pleura intersection_of: RO:0002220 UBERON:0002048 ! adjacent to lung relationship: BFO:0000050 UBERON:0000977 ! part of pleura relationship: BFO:0000050 UBERON:0002048 {source="FMA"} ! part of lung relationship: RO:0002220 UBERON:0002048 ! adjacent to lung relationship: RO:0002371 UBERON:0008946 ! attached to lung parenchyma relationship: RO:0002433 UBERON:0000977 ! contributes to morphology of pleura property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "visceral pleura" xsd:string [Term] id: UBERON:0002402 name: pleural cavity def: "The fluid-filled cavity that lies between the visceral and parietal pleurae." [https://github.com/obophenotype/uberon/issues/86, Wikipedia:Pleural_cavity] subset: pheno_slim subset: uberon_slim synonym: "cavitas pleuralis" EXACT OMO:0003011 [Wikipedia:Pleural_cavity] synonym: "cavitum pleuralae" RELATED OMO:0003011 [Wikipedia:Pleural_cavity] synonym: "cavitum pleurale" RELATED OMO:0003011 [Wikipedia:Pleural_cavity] xref: BTO:0004422 xref: EHDAA2:0001475 xref: EMAPA:16773 xref: EMAPA:16774 xref: FMA:9740 xref: GAID:95 xref: MA:0000055 xref: MESH:D035422 xref: NCIT:C12840 xref: SCTID:361999006 xref: UMLS:C0178802 {source="ncithesaurus:Pleural_Cavity"} xref: VHOG:0000581 xref: Wikipedia:Pleural_cavity is_a: BFO:0000002 is_a: UBERON:0035809 ! serous cavity intersection_of: UBERON:0002553 ! anatomical cavity intersection_of: RO:0002572 UBERON:0009778 ! luminal space of pleural sac relationship: RO:0002202 UBERON:0003887 {source="Wikipedia"} ! develops from intraembryonic coelom relationship: RO:0002220 UBERON:0002400 ! adjacent to parietal pleura relationship: RO:0002220 UBERON:0002401 ! adjacent to visceral pleura relationship: RO:0002572 UBERON:0009778 ! luminal space of pleural sac property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/a/ab/Gray965.png" xsd:anyURI property_value: skos:prefLabel "pleural cavity" xsd:string [Term] id: UBERON:0002405 name: immune system def: "Anatomical system that protects the body from foreign substances, cells, and tissues by producing the immune response and that includes especially the thymus, spleen, lymphoid tissue, lymphocytes including the B cells and T cells, and antibodies." [Wikipedia:Immune_system] subset: human_reference_atlas subset: pheno_slim subset: uberon_slim subset: vertebrate_core xref: AAO:0011003 xref: BILA:0000104 xref: BTO:0005810 xref: FMA:9825 xref: GAID:328 xref: MA:0002711 xref: MESH:D007107 xref: NCIT:C12735 xref: SCTID:362590003 xref: TAO:0001159 xref: UMLS:C0020962 {source="ncithesaurus:Immune_System"} xref: VHOG:0001247 xref: Wikipedia:Immune_system xref: XAO:0003152 xref: ZFA:0001159 is_a: BFO:0000004 is_a: UBERON:0015203 ! non-connected functional system disjoint_from: UBERON:0002416 ! integumental system disjoint_from: UBERON:0002423 ! hepatobiliary system disjoint_from: UBERON:0004456 ! entire sense organ system disjoint_from: UBERON:8450002 ! excretory system relationship: protects UBERON:0000468 ! multicellular organism relationship: RO:0002215 GO:0002376 ! capable of immune system process relationship: RO:0002492 UBERON:0000066 ! existence ends during fully formed stage property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "immune system" xsd:string [Term] id: UBERON:0002406 name: pericardial sac def: "A double-walled sac containing the heart and the roots of the great vessels." [https://github.com/obophenotype/uberon/issues/86, Wikipedia:Pericardium] subset: uberon_slim subset: vertebrate_core synonym: "pericardium" RELATED [] xref: FMA:9868 xref: RETIRED_EHDAA2:0001443 xref: SCTID:361326002 is_a: UBERON:0005181 ! thoracic segment organ is_a: UBERON:0005906 ! serous sac intersection_of: UBERON:0005906 ! serous sac intersection_of: BFO:0000051 UBERON:0001074 ! has part pericardial cavity intersection_of: BFO:0000051 UBERON:0002357 ! has part serous pericardium relationship: BFO:0000050 UBERON:0002407 ! part of pericardium relationship: BFO:0000051 UBERON:0001074 ! has part pericardial cavity relationship: BFO:0000051 UBERON:0002357 ! has part serous pericardium relationship: RO:0002219 UBERON:0002359 {source="FMA"} ! surrounded by fibrous pericardium property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/7/7e/Gray489.png" xsd:anyURI property_value: skos:prefLabel "pericardial sac" xsd:string [Term] id: UBERON:0002407 name: pericardium def: "The combination of pericardial sac (a double-walled sac containing the heart and the roots of the great vessels) plus fibrous pericardium." [http://orcid.org/0000-0002-6601-2165, Wikipedia:Pericardium] subset: efo_slim subset: human_reference_atlas subset: pheno_slim subset: uberon_slim subset: vertebrate_core xref: AAO:0010817 xref: BSA:0000090 xref: BTO:0000717 xref: CALOHA:TS-0761 xref: EFO:0000820 xref: EHDAA:5376 xref: EV:0100023 xref: FMA:9869 xref: GAID:569 xref: galen:Pericardium xref: MA:0000099 xref: MAT:0000454 xref: MESH:D010496 xref: NCIT:C13005 xref: RETIRED_EHDAA2:0001443 xref: SCTID:181295003 xref: UMLS:C0031050 {source="ncithesaurus:Pericardium"} xref: VHOG:0001280 xref: Wikipedia:Pericardium xref: XAO:0004182 xref: ZFA:0000054 is_a: BFO:0000002 is_a: UBERON:0000481 ! multi-tissue structure relationship: BFO:0000050 UBERON:0015410 {source="MA"} ! part of heart plus pericardium relationship: BFO:0000051 UBERON:0002359 ! has part fibrous pericardium relationship: BFO:0000051 UBERON:0002406 ! has part pericardial sac relationship: RO:0002221 UBERON:0002349 ! surrounds myocardium property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/7/7e/Gray489.png" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "pericardium" xsd:string [Term] id: UBERON:0002408 name: parietal serous pericardium def: "Parietal serous membrane which is part of the pericardium and forms the outer layer of the pericardial sac." [http://orcid.org/0000-0002-6601-2165] subset: pheno_slim subset: uberon_slim synonym: "lamina parietalis (pericardii serosum)" EXACT [] synonym: "lamina parietalis pericardii" EXACT OMO:0003011 [FMA:9870, FMA:TA] synonym: "parietal layer of serous pericardium" EXACT [] synonym: "parietal pericardium" EXACT [VHOG:0000537] synonym: "pericardial sac" RELATED INCONSISTENT [DOI:10.5962/bhl.title.1013] xref: EHDAA:3422 xref: EHDAA:5378 xref: EMAPA:19031 xref: FMA:9870 xref: MA:0000483 xref: NCIT:C94500 xref: SCTID:243956000 xref: UMLS:C0225969 {source="ncithesaurus:Parietal_Pericardium"} xref: VHOG:0000537 xref: Wikipedia:Parietal_pericardium is_a: UBERON:0022351 ! parietal serous membrane intersection_of: UBERON:0022351 ! parietal serous membrane intersection_of: BFO:0000050 UBERON:0002357 ! part of serous pericardium relationship: BFO:0000050 UBERON:0002357 ! part of serous pericardium property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/7/7e/Gray489.png" xsd:anyURI property_value: skos:prefLabel "parietal serous pericardium" xsd:string [Term] id: UBERON:0002409 name: pericardial fluid def: "Transudate contained in the pericardial cavity.[FMA]." [FMA:9887, Wikipedia:Pericardial_fluid] subset: uberon_slim xref: BTO:0001016 xref: FMA:9887 xref: MA:0002530 xref: Wikipedia:Pericardial_fluid is_a: UBERON:0007794 {source="FMA"} ! secretion of serous gland is_a: UBERON:0036217 ! coelomic fluid intersection_of: UBERON:0000463 ! organism substance intersection_of: RO:0003001 UBERON:0002425 ! produced by visceral serous pericardium relationship: RO:0001025 UBERON:0001074 ! located in pericardial cavity relationship: RO:0003001 UBERON:0002425 ! produced by visceral serous pericardium property_value: skos:prefLabel "pericardial fluid" xsd:string [Term] id: UBERON:0002410 name: autonomic nervous system def: "The autonomic nervous system is composed of neurons that are not under conscious control, and is comprised of two antagonistic components, the sympathetic and parasympathetic nervous systems. The autonomic nervous system regulates key functions including the activity of the cardiac (heart) muscle, smooth muscles (e.g. of the gut), and glands[GO]." [GO:0048483] subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "ANS" RELATED OMO:0003000 [] synonym: "autonomic division of peripheral nervous system" EXACT [FMA:65553] synonym: "autonomic part of peripheral nervous system" EXACT [FMA:65553] synonym: "divisio autonomica systematis nervosi peripherici" EXACT [FMA:TA] synonym: "divisio autonomica systematis nervosi peripherici" RELATED OMO:0003011 [Wikipedia:Autonomic_nervous_system] synonym: "pars autonomica systematis nervosi peripherici" EXACT [FMA:TA] synonym: "peripheral autonomic nervous system" EXACT [FMA:65553] synonym: "visceral nervous system" EXACT [] xref: AAO:0000033 xref: BIRNLEX:1123 xref: BTO:0002507 xref: CALOHA:TS-2001 xref: EHDA:10095 xref: EHDAA2:0000158 xref: EHDAA:3767 xref: EMAPA:16984 xref: FMA:65553 xref: GAID:706 xref: IDOMAL:0002126 {sssom:mapping_justification="https://w3id.org/semapv/vocab/LexicalMatching"} xref: MA:0000219 xref: MESH:D001341 xref: NCIT:C12673 xref: neuronames:2054 xref: SCTID:362481007 xref: TAO:0001574 xref: UMLS:C0004388 {source="ncithesaurus:Autonomic_Nervous_System", source="BIRNLEX:1123"} xref: UMLS:C1305381 {source="BIRNLEX:1123"} xref: VHOG:0000396 xref: Wikipedia:Autonomic_nervous_system xref: ZFA:0001574 is_a: UBERON:0011216 {source="cjm"} ! organ system subdivision relationship: BFO:0000050 UBERON:0000010 {source="EMAPA", source="MA", source="NIFSTD", source="ZFA-modified-from-isa"} ! part of peripheral nervous system relationship: RO:0002162 NCBITaxon:7742 ! in taxon Vertebrata relationship: RO:0002433 UBERON:0001016 ! contributes to morphology of nervous system property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/f/f7/Gray839.png" xsd:anyURI property_value: skos:prefLabel "autonomic nervous system" xsd:string [Term] id: UBERON:0002411 name: clitoris def: "The small, erectile body located at the anterior end of the vulva." [ISBN:0-683-40008-8, MP:0003127] subset: organ_slim subset: pheno_slim subset: uberon_slim xref: BTO:0002020 xref: EHDAA2:0000255 xref: EHDAA:9360 xref: EMAPA:30819 xref: FMA:9909 xref: GAID:385 xref: galen:Clitoris xref: MA:0000382 xref: MESH:D002987 xref: NCIT:C12308 xref: SCTID:181442003 xref: UMLS:C0008984 {source="ncithesaurus:Clitoris"} xref: VHOG:0000700 xref: Wikipedia:Clitoris is_a: BFO:0000002 is_a: UBERON:0000062 {source="Wikipedia"} ! organ is_a: UBERON:0005156 ! reproductive structure relationship: BFO:0000050 UBERON:0000997 {source="MA"} ! part of mammalian vulva relationship: RO:0002202 UBERON:0005876 {source="EHDAA2", source="Wikipedia"} ! develops from undifferentiated genital tubercle relationship: RO:0002433 UBERON:0005056 ! contributes to morphology of external female genitalia property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/c/cf/Clitoris_anatomy_labeled-en.svg" xsd:anyURI [Term] id: UBERON:0002412 name: vertebra def: "The ossified form of a vertebral element, a skeletal element that forms around the notochord and is part of the vertebral column." [GO_REF:0000034, http://dx.plos.org/10.1371/journal.pone.0051070, http://orcid.org/0000-0002-6601-2165, VSAO:0000184] subset: efo_slim subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "vertebra bone" EXACT [] synonym: "vertebrae" EXACT OMO:0003004 [PHENOSCAPE:ad] xref: AAO:0000691 xref: CALOHA:TS-2352 xref: EFO:0001371 xref: EMAPA:32740 xref: FMA:9914 xref: galen:Vertebra xref: MA:0000309 xref: NCIT:C12933 xref: SCTID:181817002 xref: TAO:0001189 xref: UMLS:C0549207 {source="ncithesaurus:Vertebra"} xref: Wikipedia:Vertebra xref: XAO:0004019 xref: ZFA:0001189 is_a: UBERON:0002513 ! endochondral bone is_a: UBERON:0008001 {source="FMA"} ! irregular bone is_a: UBERON:0010913 ! vertebral element intersection_of: UBERON:0010913 ! vertebral element intersection_of: RO:0002473 UBERON:0002481 ! composed primarily of bone tissue relationship: BFO:0000050 UBERON:0001130 ! part of vertebral column relationship: RO:0002202 UBERON:0011094 ! develops from vertebra cartilage element property_value: IAO:0000116 "Consider changing name to make distinction from inferred superclass 'vertebral element' clear" xsd:string property_value: IAO:0000116 "we follow FMA in making this an irregular bone - however vertebra have 'epiphyses' which are currently classified as belonging to long bones" xsd:string property_value: RO:0002161 NCBITaxon:7901 {source="Wikipedia"} property_value: skos:prefLabel "vertebra" xsd:string [Term] id: UBERON:0002413 name: cervical vertebra def: "A vertebra that is located in the cervical region of the vertebral column." [http://orcid.org/0000-0002-6601-2165] subset: human_reference_atlas subset: pheno_slim subset: uberon_slim synonym: "cervical vertebrae" EXACT OMO:0003004 [] synonym: "vertebrae cervicales" RELATED OMO:0003011 [Wikipedia:Cervical_vertebrae] xref: EMAPA:17674 xref: FMA:9915 xref: GAID:235 xref: galen:CervicalVertebra xref: MA:0000311 xref: MESH:D002574 xref: NCIT:C12693 xref: SCTID:181820005 xref: Wikipedia:Cervical_vertebrae xref: XAO:0003076 is_a: UBERON:0003458 ! neck bone is_a: UBERON:0004451 {is_inferred="true"} ! trunk or cervical vertebra is_a: UBERON:0015007 ! cervical vertebra endochondral element intersection_of: UBERON:0015007 ! cervical vertebra endochondral element intersection_of: RO:0002473 UBERON:0002481 ! composed primarily of bone tissue relationship: RO:0002202 UBERON:0013505 ! develops from cervical vertebra cartilage element property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/f/f8/Illu_vertebral_column.jpg" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "cervical vertebra" xsd:string [Term] id: UBERON:0002414 name: lumbar vertebra def: "Large vertebra of the movable part of the vertebral column, characterized by the absence of the foramen transversarium within the transverse process, and by the absence of facets on the sides of the body." [Wikipedia:Lumbar_vertebrae] subset: human_reference_atlas subset: pheno_slim subset: uberon_slim xref: CALOHA:TS-2364 xref: EMAPA:18007 xref: FMA:9921 xref: GAID:240 xref: galen:LumbarVertebra xref: MA:0000312 xref: MESH:D008159 xref: NCIT:C12744 xref: SCTID:181822002 xref: UMLS:C0024091 {source="ncithesaurus:Lumbar_Vertebra"} xref: Wikipedia:Lumbar_vertebrae is_a: UBERON:0002412 ! vertebra is_a: UBERON:0003828 ! abdominal segment bone is_a: UBERON:0004247 ! bone of dorsum is_a: UBERON:0015009 ! lumbar vertebra endochondral element intersection_of: UBERON:0015009 ! lumbar vertebra endochondral element intersection_of: RO:0002473 UBERON:0002481 ! composed primarily of bone tissue relationship: RO:0002202 UBERON:0013509 ! develops from lumbar vertebra cartilage element property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/c/c8/Gray93.png" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0002415 name: tail def: "An external caudal extension of the body. In chordates, the tail is post-anal, in other animals the anus ends in the tail." [AEO:0000109, Wikipedia:Tail] subset: efo_slim subset: grouping_class subset: pheno_slim subset: uberon_slim synonym: "caudal subdivision" EXACT [https://orcid.org/0000-0002-6601-2165] xref: AEO:0000109 xref: BILA:0000117 xref: BTO:0001348 xref: EFO:0000963 xref: EHDAA:9198 xref: GAID:1245 xref: MAT:0000094 xref: MESH:D013623 xref: MIAA:0000094 xref: WBbt:0005741 xref: Wikipedia:Tail is_a: UBERON:0011676 ! subdivision of organism along main body axis relationship: BFO:0000050 UBERON:0000154 ! part of posterior region of body property_value: IAO:0000116 "Note we also have a subclass post-anal tail, for the chordate specific structure. currently defined very generally, inclusive of caudal fin" xsd:string property_value: RO:0002161 NCBITaxon:9606 property_value: skos:prefLabel "tail" xsd:string [Term] id: UBERON:0002416 name: integumental system def: "Connected anatomical system that forms a barrier between an animal and its environment. In vertebrates, the integumental system consists of the epidermis, dermis plus associated glands and adnexa such as hair and scales. In invertebrates, the integumental system may include cuticle." [CARO:0002001, http://orcid.org/0000-0002-6601-2165, https://github.com/obophenotype/uberon/issues/29] subset: efo_slim subset: grouping_class subset: human_reference_atlas subset: pheno_slim synonym: "body surface" RELATED [] synonym: "dermal system" RELATED [MIAA:0000033] synonym: "external covering of organism" RELATED [] synonym: "integumentary system" EXACT [FMA:72979] synonym: "integumentum commune" RELATED OMO:0003011 [Wikipedia:Integumentary_system] synonym: "organism surface" RELATED [EHDAA2:0003154] synonym: "surface" RELATED [BILA:0000118] xref: AEO:0000154 xref: BILA:0000118 xref: CALOHA:TS-1299 xref: CARO:0002001 xref: EFO:0000807 xref: EHDAA2:0000836 xref: EHDAA2_RETIRED:0003154 xref: EHDAA:6520 xref: EMAPA:17524 xref: EV:0100151 xref: FBbt:00004969 {sssom:mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"} xref: FMA:72979 xref: galen:Surface xref: HAO:0000421 xref: MA:0000014 xref: MAT:0000033 xref: MESH:D034582 xref: MIAA:0000033 xref: NCIT:C12907 xref: SCTID:361692004 xref: TADS:0000108 xref: UMLS:C0037267 {source="ncithesaurus:Integumentary_System"} xref: VHOG:0000403 xref: Wikipedia:Integumentary_system xref: XAO:0000176 is_a: BFO:0000002 is_a: UBERON:0000467 ! anatomical system disjoint_from: UBERON:0002423 ! hepatobiliary system disjoint_from: UBERON:0004456 ! entire sense organ system disjoint_from: UBERON:8450002 ! excretory system relationship: BFO:0000051 UBERON:0007376 ! has part outer epithelium relationship: RO:0002007 UBERON:0000468 ! bounding layer of multicellular organism relationship: RO:0002219 UBERON:0013514 ! surrounded by space surrounding organism relationship: RO:0002492 UBERON:0000066 ! existence ends during fully formed stage property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "integumental system" xsd:string property_value: terms:contributor https://orcid.org/0000-0002-0956-8634 property_value: terms:contributor https://orcid.org/0000-0002-6601-2165 [Term] id: UBERON:0002417 name: abdominal segment of trunk def: "The abdominal segment of the torso." [Wikipedia:Lumbar] synonym: "abdomen/pelvis/perineum" RELATED [MA:0000021] synonym: "lower body" RELATED [MA:0000021] synonym: "lower trunk" RELATED [FMA:259211] synonym: "lumbar region" RELATED [https://orcid.org/0000-0002-6601-2165] xref: EMAPA:35104 xref: FMA:259211 xref: MA:0000021 xref: SCTID:362875007 xref: Wikipedia:Lumbar is_a: UBERON:0009569 {source="FMA"} ! subdivision of trunk is_a: UBERON:0011676 ! subdivision of organism along main body axis property_value: skos:prefLabel "abdominal segment of trunk" xsd:string [Term] id: UBERON:0002418 name: cartilage tissue def: "Skeletal tissue that is avascular, rich in glycosaminoglycans (GAGs) and typically includes chondrocytes within isolated lacunae. Cartilage tissue is deposited by chondroblasts." [GO_REF:0000034, http://dx.plos.org/10.1371/journal.pone.0051070, https://github.com/obophenotype/uberon/issues/37, https://sourceforge.net/p/obo/vertebrate-skeletal-anatomy-vsao-term-requests/5, PSPUB:0000170, VSAO:0000040] comment: Previous: "A portion of connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate[GO]. Regular connective tissue, which consists of chondrocytes and related cells, the intercellular matrix of which is chondrified. Examples: hyaline cartilage, fibrocartilage, elastic cartilage[FMA]. an avascular supporting and articular skeletal tissue. It also functions as the primary endoskeletal support in vertebrate embryos. Cartilage is deposited by and is composed of chondroblasts and chondrocytes separated by an extracellular matrix, which may or may not mineralize depending on cartilage type, age, or taxon[Hall and Witten]." See also FMA:71500 Set of cartilages, FMA:55107 Cartilage organ, FMA:12264 Articular cartilage. // elements made from cartilage, cartilage-like, or chondroid tissues evolved in invertebrates[H&W] subset: efo_slim subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "cartilage" RELATED [] synonym: "cartilage tissue" EXACT [FMA:37377] synonym: "cartilages" RELATED [VHOG:0001207] synonym: "cartilaginous tissue" EXACT [] synonym: "chondrogenic tissue" EXACT [VSAO:0000040] synonym: "portion of cartilage tissue" RELATED [FMA:37377] xref: AAO:0000060 xref: AEO:0000087 xref: BTO:0000206 xref: EFO:0000949 xref: EHDAA2:0003087 xref: EMAPA:32730 xref: EV:0100141 xref: FMA:37377 xref: GAID:99 xref: galen:Cartilage xref: MA:0000104 xref: MAT:0000189 xref: MESH:D002356 xref: MIAA:0000189 xref: NCIT:C12373 xref: NCIT:C32268 xref: SCTID:309312004 xref: TAO:0001501 xref: UMLS:C0007301 {source="ncithesaurus:Cartilage"} xref: VHOG:0001207 xref: VSAO:0000040 xref: Wikipedia:Cartilage xref: XAO:0000170 xref: ZFA:0005622 is_a: UBERON:0004755 ! skeletal tissue disjoint_from: UBERON:0002481 {source="https://github.com/obophenotype/uberon/issues/117"} ! bone tissue relationship: BFO:0000051 CHEBI:18085 ! has part relationship: BFO:0000051 CL:0000138 ! has part chondrocyte relationship: RO:0002433 UBERON:0001434 ! contributes to morphology of skeletal system property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/e/ee/Hypertrophic_Zone_of_Epiphyseal_Plate.jpg" xsd:anyURI property_value: skos:prefLabel "cartilage tissue" xsd:string property_value: terms:contributor https://orcid.org/0000-0001-9114-8737 property_value: terms:contributor https://orcid.org/0000-0002-6601-2165 [Term] id: UBERON:0002419 name: skin gland def: "A gland that is part of a skin of body [Automatically generated definition]." [OBOL:automatic] subset: organ_slim synonym: "glandulae cutis" EXACT OMO:0003011 [FMA:71878, FMA:TA] synonym: "set of skin glands" RELATED [FMA:71878] synonym: "skin glands" RELATED OMO:0003004 [] synonym: "skin glands set" RELATED OMO:0003004 [] xref: EMAPA:35774 xref: FMA:71878 xref: MA:0000146 xref: SCTID:110485007 is_a: UBERON:0003297 ! gland of integumental system is_a: UBERON:0006003 ! integumentary adnexa intersection_of: UBERON:0002530 ! gland intersection_of: BFO:0000050 UBERON:0002097 ! part of skin of body relationship: BFO:0000050 UBERON:0002097 ! part of skin of body property_value: IAO:0000116 "check FMA, use plural for now as general class not there" xsd:string property_value: skos:prefLabel "skin gland" xsd:string [Term] id: UBERON:0002420 name: basal ganglion def: "An individual member of a collection of basal ganglia. Basal ganglia are subcortical masses of gray matter in the forebrain and midbrain that are richly interconnected and so viewed as a functional system. The nuclei usually included are the caudate nucleus (caudoputamen in rodents), putamen, globus pallidus, substantia nigra (pars compacta and pars reticulata) and the subthalamic nucleus. Some also include the nucleus accumbens and ventral pallidum[NIF,modified]." [BIRNLEX:826] subset: efo_slim subset: human_reference_atlas subset: pheno_slim subset: uberon_slim synonym: "basal ganglia" RELATED OMO:0003004 [] synonym: "basal ganglion of telencephalon" EXACT [] synonym: "basal nucleus" RELATED [MA:0000184] synonym: "nuclei basales" RELATED OMO:0003011 [Wikipedia:Basal_ganglia] xref: BTO:0000235 xref: CALOHA:TS-1149 xref: DHBA:10332 xref: EFO:0000904 xref: FMA:62514 xref: SCTID:244434001 is_a: UBERON:0003528 ! brain gray matter is_a: UBERON:0007245 {source="FMA"} ! nuclear complex of neuraxis relationship: BFO:0000050 UBERON:0010011 ! part of collection of basal ganglia property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/1/1b/Basal_Ganglia_and_Related_Structures.svg" xsd:anyURI property_value: IAO:0000116 "it is necessary to introduce two classes, one representing an individual basal ganglion, another representing the aggregate structure, in order to have consistent classification amongst AOs (e.g. in MA the aygdala is part of the BG, in FMA and BTO it is a subclass). Apart from achieving this consistency, the value of having two distinct classes is questionable, since the BG-plural is trivially the set of all BGs-singular. it would be better for all AOs to decide on one single way of doing this. Do not merge until this is done." xsd:string property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "basal ganglion" xsd:string [Term] id: UBERON:0002421 name: hippocampal formation def: "Hippocampus (proper) plus dentate gyrus and subiculum[definition derived from NIF comments and ontology alignment]." [https://orcid.org/0000-0002-6601-2165] subset: human_reference_atlas subset: pheno_slim subset: uberon_slim synonym: "archipallium" RELATED [MA:0000189] synonym: "formatio hippocampi" RELATED OMO:0003011 [NeuroNames:177] synonym: "hippocampus" NARROW INCONSISTENT [BTO:0000601, GO:0021766] synonym: "hippocampus (Crosby)" EXACT [] synonym: "major hippocampus" RELATED [BTO:0000601] synonym: "primal cortex" RELATED [MA:0000189] synonym: "seahorse" RELATED [NeuroNames:177] xref: BAMS:Hi xref: BAMS:HiF xref: BAMS:HPF xref: BIRNLEX:715 xref: BM:Tel-HF xref: BTO:0000601 xref: DHBA:10294 xref: EMAPA:35405 xref: FMA:74038 xref: HBA:4249 xref: MA:0000189 xref: MBA:1089 xref: neuronames:177 {source="BIRNLEX:715"} xref: PBA:4003 xref: SCTID:422867004 xref: UMLS:C0175202 {source="BIRNLEX:715"} xref: Wikipedia:Hippocampal_formation is_a: UBERON:0002616 ! regional part of brain relationship: BFO:0000050 UBERON:0000956 {source="MBA-indirect", source="NIFSTD"} ! part of cerebral cortex relationship: RO:0002162 NCBITaxon:40674 {source="Wikipedia:Hippocampus"} ! in taxon Mammalia property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/brain-female/v1.4/assets/3d-allen-f-brain.glb" xsd:anyURI property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/brain-male/v1.4/assets/3d-allen-m-brain.glb" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "hippocampal formation" xsd:string [Term] id: UBERON:0002422 name: fourth ventricle def: "Part of the ventricular system of the brain, forming a single large irregularly shaped cavity located on the midline of the rhombencephalon, between the medulla, pons and the isthmus ventrally and the cerebellum dorsally. It is continuous with the cerebral aqueduct anteriorally and the central canal of the spinal cord posteriorly. It communicates with the subarachnoid space through its lateral and median apertures." [BIRNLEX:1256] subset: human_reference_atlas subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "4th ventricle" RELATED [MA:0000196] synonym: "fourth ventricle proper" RELATED [BAMS:V4] synonym: "hindbrain ventricle" RELATED NON_MAMMAL [VHOG:0000006] synonym: "IVth ventricle" RELATED [VHOG:0000006] synonym: "rhombencephalic ventricle" RELATED [VHOG:0000006] synonym: "rhombencephalic vesicle" NARROW [ZFA:0000110] synonym: "ventricle IV" EXACT [ZFA:0000110] synonym: "ventricle of hindbrain" RELATED NON_MAMMAL [BTO:0003426] synonym: "ventricle of rhombencephalon" RELATED [BTO:0003426] synonym: "ventriculus quartus" RELATED OMO:0003011 [Wikipedia:Fourth_ventricle] xref: AAO:0011043 xref: BAMS:4V xref: BAMS:V4 xref: BIRNLEX:1256 xref: BM:Pons-4V xref: BTO:0003426 xref: CALOHA:TS-2015 xref: DHBA:12805 xref: DMBA:126651782 xref: EHDAA2:0000100 xref: EHDAA:896 xref: EMAPA:16917 xref: EV:0100310 xref: FMA:78469 xref: GAID:610 xref: HBA:9421 xref: MA:0000196 xref: MBA:145 xref: MESH:D020546 xref: NCIT:C12828 xref: neuronames:621 xref: SCTID:180932000 xref: TAO:0000110 xref: UMLS:C0149556 {source="ncithesaurus:Fourth_Ventricle_of_the_Brain"} xref: VHOG:0000006 xref: Wikipedia:Fourth_ventricle xref: XAO:0003099 xref: ZFA:0000110 is_a: BFO:0000002 is_a: UBERON:0004086 ! brain ventricle intersection_of: UBERON:0004086 ! brain ventricle intersection_of: BFO:0000050 UBERON:0002028 ! part of hindbrain relationship: BFO:0000050 UBERON:0002028 ! part of hindbrain relationship: RO:0002202 UBERON:0013149 {source="EHDAA2"} ! develops from hindbrain vesicle relationship: RO:0002433 UBERON:0002028 ! contributes to morphology of hindbrain property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/7/7d/Gray734.png" xsd:anyURI property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/brain-female/v1.4/assets/3d-allen-f-brain.glb" xsd:anyURI property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/brain-male/v1.4/assets/3d-allen-m-brain.glb" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "fourth ventricle" xsd:string [Term] id: UBERON:0002423 name: hepatobiliary system def: "The part of the digestive system that contains the liver and the biliary system." [http://orcid.org/0000-0002-6601-2165] subset: efo_slim subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "hepaticobiliary system" EXACT [GO:0061008] synonym: "liver and biliary system" EXACT [] synonym: "liver/biliary system" RELATED [] xref: AAO:0011056 xref: CALOHA:TS-1308 xref: EFO:0000800 xref: EHDAA2:0000998 xref: EHDAA:2189 xref: EMAPA:16840 xref: EV:0100088 xref: MA:0000324 xref: MAT:0000024 xref: MIAA:0000024 xref: NCIT:C43612 xref: TAO:0000036 xref: UMLS:C1711359 {source="ncithesaurus:Hepatobiliary_System"} xref: VHOG:0000294 xref: Wikipedia:Hepatobiliary_system xref: XAO:0000132 xref: ZFA:0000036 is_a: BFO:0000002 is_a: UBERON:0011216 ! organ system subdivision disjoint_from: UBERON:0004456 ! entire sense organ system disjoint_from: UBERON:8450002 ! excretory system relationship: BFO:0000050 UBERON:0001007 ! part of digestive system relationship: BFO:0000051 UBERON:0002107 ! has part liver relationship: BFO:0000051 UBERON:0002294 ! has part biliary system relationship: RO:0002215 GO:0061007 ! capable of hepaticobiliary system process relationship: RO:0002492 UBERON:0000066 ! existence ends during fully formed stage property_value: skos:prefLabel "hepatobiliary system" xsd:string [Term] id: UBERON:0002424 name: oral epithelium def: "An epithelium that is part of the mouth and lines the oral cavity, typically stratified squamous, and may be para-, ortho- or non- keratinized. Primary barrier between oral environment and deeper tissues." [https://orcid.org/0000-0002-6601-2165] subset: vertebrate_core synonym: "epithelium of mucosa of mouth" EXACT [FMA:265152] synonym: "epithelium of oral mucosa" EXACT [FMA:265152] xref: AAO:0010357 xref: BTO:0001775 xref: CALOHA:TS-0715 xref: EHDAA2:0001325 xref: EHDAA:2187 xref: EMAPA:16839 xref: EMAPA:26942 xref: FMA:265152 xref: MA:0000344 xref: NCIT:C49595 xref: TAO:0000816 xref: UMLS:C1709332 {source="ncithesaurus:Oral_Cavity_Epithelium"} xref: VHOG:0000187 xref: XAO:0003201 xref: ZFA:0000816 is_a: UBERON:0003350 ! epithelium of mucosa is_a: UBERON:0003929 ! digestive tract epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: BFO:0000050 UBERON:0003729 ! part of mouth mucosa relationship: BFO:0000050 UBERON:0003729 ! part of mouth mucosa relationship: RO:0002220 UBERON:0000167 {source="AAO-modified"} ! adjacent to oral cavity property_value: IAO:0000116 "consider including separate class for developmental structure (adult human is stratified; in EHDAA2 is unilaminar)" xsd:string property_value: skos:prefLabel "oral epithelium" xsd:string [Term] id: UBERON:0002425 name: visceral serous pericardium def: "Visceral serous membrane which is continuous with the parietal serous pericardium and is attached to the myocardium[FMA]." [Wikipedia:Visceral_pericardium] subset: pheno_slim subset: uberon_slim synonym: "epicardium" RELATED [MA:0000484] synonym: "lamina visceralis pericardii serosi" EXACT OMO:0003011 [Wikipedia:Epicardium] synonym: "pericardium visceral mesothelium" RELATED [EMAPA:16589] synonym: "serous visceral pericardium" EXACT [] synonym: "visceral lamina of serous pericardium" EXACT [] synonym: "visceral layer of serous pericardium" EXACT [] synonym: "visceral pericardium" EXACT [VHOG:0000538] xref: EMAPA:19032 xref: FMA:84882 xref: MA:0000484 xref: SCTID:243955001 xref: VHOG:0000538 xref: Wikipedia:Visceral_pericardium is_a: BFO:0000002 is_a: UBERON:0022350 ! visceral serous membrane intersection_of: UBERON:0022350 ! visceral serous membrane intersection_of: BFO:0000050 UBERON:0002357 ! part of serous pericardium relationship: BFO:0000050 UBERON:0002357 ! part of serous pericardium relationship: BFO:0000051 UBERON:0002348 {source="cjm"} ! has part epicardium relationship: RO:0002371 UBERON:0002349 {source="FMA"} ! attached to myocardium relationship: RO:0002433 UBERON:0002407 ! contributes to morphology of pericardium property_value: skos:prefLabel "visceral serous pericardium" xsd:string [Term] id: UBERON:0002426 name: chest muscle def: "Any muscle organ that is part of a chest [Automatically generated definition]." [OBOL:automatic] subset: human_reference_atlas synonym: "anterior thoracic region muscle organ" EXACT [OBOL:automatic] synonym: "anterolateral part of thorax muscle organ" EXACT [OBOL:automatic] synonym: "chest muscle organ" EXACT [OBOL:automatic] synonym: "front of thorax muscle organ" EXACT [OBOL:automatic] synonym: "muscle of thorax" EXACT [FMA:9619] synonym: "muscle organ of anterior thoracic region" EXACT [OBOL:automatic] synonym: "muscle organ of anterolateral part of thorax" EXACT [OBOL:automatic] synonym: "muscle organ of chest" EXACT [OBOL:automatic] synonym: "muscle organ of front of thorax" EXACT [OBOL:automatic] synonym: "musculus thoracicus" EXACT [] synonym: "thoracic muscle" EXACT [] xref: BTO:0000508 xref: CALOHA:TS-1037 xref: EMAPA:17747 xref: FMA:9619 xref: MA:0000548 is_a: UBERON:0003830 ! thoracic segment muscle is_a: UBERON:0005175 ! chest organ intersection_of: UBERON:0014892 ! skeletal muscle organ, vertebrate intersection_of: BFO:0000050 UBERON:0001443 ! part of chest property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0002427 name: arm skin def: "A zone of skin that is part of an arm [Automatically generated definition]." [OBOL:automatic] synonym: "brachial region skin" RELATED [OBOL:automatic] synonym: "skin of arm" EXACT [OBOL:automatic] xref: EMAPA:37350 {source="MA:th"} xref: MA:0000596 xref: NCIT:C52754 xref: UMLS:C0222204 {source="ncithesaurus:Arm_Skin"} is_a: UBERON:0003531 ! forelimb skin intersection_of: UBERON:0000014 ! zone of skin intersection_of: BFO:0000050 UBERON:0001460 ! part of arm relationship: BFO:0000050 UBERON:0001460 ! part of arm [Term] id: UBERON:0002428 name: limb bone def: "A bone that is part of a limb [Automatically generated definition]." [OBOL:automatic] subset: efo_slim subset: pheno_slim synonym: "bone of extremity" EXACT [] synonym: "bone of limb" EXACT [OBOL:automatic] synonym: "free limb bone" EXACT [https://orcid.org/0000-0002-6601-2165, UBERONREF:0000003] xref: EFO:0000945 xref: MAT:0000151 xref: MIAA:0000151 xref: NCIT:C32223 xref: SCTID:304149004 xref: UMLS:C0582791 {source="ncithesaurus:Bone_of_the_Extremity"} is_a: UBERON:0002513 ! endochondral bone is_a: UBERON:0004375 ! bone of free limb or fin is_a: UBERON:0015061 ! limb endochondral element intersection_of: UBERON:0001474 ! bone element intersection_of: BFO:0000050 UBERON:0002101 ! part of limb relationship: RO:0002202 UBERON:0010881 ! develops from limb cartilage element [Term] id: UBERON:0002429 name: cervical lymph node def: "Cervical lymph nodes are lymph nodes found in the neck. [WP,unvetted]." [Wikipedia:Cervical_lymph_node] subset: pheno_slim subset: uberon_slim synonym: "lymph node of neck" EXACT [] xref: FMA:61213 xref: MA:0000736 xref: NCIT:C32298 xref: SCTID:181757009 xref: UMLS:C0588054 {source="ncithesaurus:Cervical_Lymph_Node"} xref: Wikipedia:Cervical_lymph_nodes is_a: UBERON:0000029 ! lymph node intersection_of: UBERON:0000029 ! lymph node intersection_of: BFO:0000050 UBERON:0000974 ! part of neck relationship: BFO:0000050 UBERON:0000974 ! part of neck property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/4/4c/Lymph_node_regions.jpg" xsd:anyURI [Term] id: UBERON:0002435 name: striatum def: "A region of the forebrain consisting of the caudate nucleus, putamen and fundus striati.[GO]." [GOC:jl, Wikipedia:Striatum] subset: human_reference_atlas subset: pheno_slim subset: uberon_slim synonym: "caudate putamen" RELATED [BIRNLEX:1672] synonym: "corpus striatum" RELATED [MA:0000891] synonym: "corpus striatum (Zilles)" RELATED OMO:0003011 [NeuroNames:225] synonym: "dorsal striatum" RELATED [BIRNLEX:1672] synonym: "neostriatum" EXACT [BIRNLEX:1672, GO:0021756, Wikipedia:Striatum] synonym: "neuraxis striatum" EXACT [FMA:83683] synonym: "striate nucleus" EXACT [GO:0021756, Wikipedia:Striatum] synonym: "striated nucleus" RELATED [BTO:0000418] synonym: "striatum" EXACT [BIRNLEX:1672] synonym: "striatum of neuraxis" EXACT [FMA:83683] xref: BAMS:STR xref: BAMS:Str xref: BAMS:Striatum xref: BIRNLEX:1672 xref: BM:N xref: BTO:0000418 xref: DHBA:10333 xref: DMBA:15851 xref: EFO:0000109 xref: EMAPA:17549 xref: FMA:77618 xref: FMA:83683 xref: HBA:4277 xref: MA:0000891 xref: MBA:477 xref: MESH:D017072 xref: NCIT:C111122 xref: ncithesaurus:Striatum xref: neuronames:225 {source="BIRNLEX:1672"} xref: PBA:10080 xref: UMLS:C0162512 {source="BIRNLEX:1672"} xref: Wikipedia:Striatum is_a: UBERON:0011300 ! gray matter of telencephalon relationship: BFO:0000050 UBERON:0000204 {source="GO"} ! part of ventral part of telencephalon relationship: BFO:0000050 UBERON:0000369 {source="BTO"} ! part of corpus striatum relationship: BFO:0000050 UBERON:0006098 {source="NIFSTD"} ! part of basal nuclear complex relationship: RO:0002433 UBERON:0010011 ! contributes to morphology of collection of basal ganglia property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/3/33/BrainCaudatePutamen.svg" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "striatum" xsd:string [Term] id: UBERON:0002437 name: cerebral hemisphere white matter def: "White matter that is part of a cerebral hemisphere." [https://orcid.org/0000-0002-6601-2165] subset: pheno_slim synonym: "cerebral hemisphere white matter" EXACT [] synonym: "cerebral white matter" EXACT [MA:0000945] synonym: "hemisphere white matter" RELATED [] synonym: "region of cerebral white matter" RELATED [FMA:256174] synonym: "substantia medullaris cerebri" RELATED OMO:0003011 [NeuroNames:189] synonym: "white matter structure of cerebral hemisphere" EXACT [FMA:61822] xref: BAMS:cw xref: BIRNLEX:711 xref: BTO:0000236 xref: CALOHA:TS-2362 xref: EMAPA:35237 xref: FMA:241998 xref: FMA:256174 xref: FMA:61822 xref: MA:0000945 xref: NCIT:C49347 xref: neuronames:189 {source="BIRNLEX:711"} xref: SCTID:361691006 xref: UMLS:C0152295 {source="ncithesaurus:Cerebral_White_Matter", source="BIRNLEX:711"} xref: UMLS:C1284115 {source="BIRNLEX:711"} is_a: UBERON:0011299 ! white matter of telencephalon intersection_of: UBERON:0002316 ! white matter intersection_of: BFO:0000050 UBERON:0001869 ! part of cerebral hemisphere relationship: BFO:0000050 UBERON:0001869 ! part of cerebral hemisphere property_value: skos:prefLabel "cerebral hemisphere white matter" xsd:string [Term] id: UBERON:0002439 name: myenteric nerve plexus def: "One of two ganglionated neural networks which together form the enteric nervous system. The myenteric (Auerbach's) plexus is located between the longitudinal and circular muscle layers of the gut. Its neurons project to the circular muscle, to other myenteric ganglia, to submucosal ganglia, or directly to the epithelium, and play an important role in regulating and patterning gut motility." [NLXANAT:100306] subset: human_reference_atlas subset: pheno_slim subset: uberon_slim synonym: "Auberbach plexus" EXACT [NLXANAT:100306] synonym: "Auberbach's plexus" EXACT [NLXANAT:100306] synonym: "Auberbachs plexus" EXACT [NLXANAT:100306] synonym: "Auerbach's plexus" EXACT [FMA:63252, HP:0002251] synonym: "Meissner's plexus" RELATED INCONSISTENT [FMA:63252] synonym: "myenteric plexus" EXACT [] synonym: "plexus myentericus" RELATED [BTO:0002436] synonym: "plexus nervosus submucosus" EXACT OMO:0003011 [FMA:63252, FMA:TA] synonym: "plexus submucosus" EXACT OMO:0003011 [FMA:63252, FMA:TA] synonym: "Remak's plexus" EXACT [FMA:63252] synonym: "submucous plexus" RELATED [] xref: BAMS:myp xref: BTO:0002436 xref: EMAPA:32847 xref: FMA:63252 xref: GAID:798 xref: MA:0001148 xref: MESH:D009197 xref: NCIT:C52748 xref: NLXANAT:100306 xref: SCTID:267716001 xref: UMLS:C0027028 {source="ncithesaurus:Myenteric_Nerve_Plexus"} xref: Wikipedia:Auerbach's_plexus is_a: UBERON:0000429 ! enteric plexus relationship: BFO:0000050 UBERON:0012367 {source="FMA"} ! part of muscle layer of intestine relationship: RO:0002216 GO:0030432 ! capable of part of peristalsis relationship: RO:0002433 UBERON:0002005 ! contributes to morphology of enteric nervous system property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0002441 name: cervicothoracic ganglion def: "The group of neurons formed by the fusion of the inferior cervical and first thoracic ganglia." [ISBN:0-683-40008-8, MESH:A08.340.315.350.800, MP:0001017] subset: human_reference_atlas subset: pheno_slim subset: uberon_slim synonym: "cervicothoracic sympathetic ganglion" EXACT [] synonym: "ganglion cervicothoracicum" EXACT OMO:0003011 [FMA:6469, FMA:TA] synonym: "ganglion stellatum" EXACT OMO:0003011 [FMA:6469, FMA:TA] synonym: "stellate ganglion" EXACT [] xref: BAMS:GSTL xref: BTO:0001815 xref: EMAPA:18226 xref: FMA:6469 xref: GAID:711 xref: MA:0001157 xref: MESH:D013233 xref: SCTID:181101006 xref: Wikipedia:Cervicothoracic_ganglion is_a: UBERON:0001991 ! cervical ganglion property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/7/7a/Gray845.png" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0002442 name: axillary nerve trunk synonym: "circumflex nerve trunk" RELATED [MA:0001175] synonym: "right axillary neural trunk" EXACT [] synonym: "trunk of right axillary nerve" EXACT [FMA:65265] xref: EMAPA:37719 {source="MA:th"} xref: FMA:65265 xref: MA:0001175 is_a: UBERON:0002464 ! nerve trunk intersection_of: UBERON:0002464 ! nerve trunk intersection_of: BFO:0000050 UBERON:0001493 ! part of axillary nerve relationship: BFO:0000050 UBERON:0001493 ! part of axillary nerve [Term] id: UBERON:0002443 name: choroidal blood vessel def: "A blood vessel that is part of a choroid [Automatically generated definition]." [OBOL:automatic] comment: cannot find singular in FMA, using Set class subset: pheno_slim synonym: "blood vessel of choroid" EXACT [OBOL:automatic] synonym: "blood vessel of choroid coat" EXACT [OBOL:automatic] synonym: "blood vessel of choroidea" EXACT [OBOL:automatic] synonym: "blood vessel of posterior uvea" EXACT [OBOL:automatic] synonym: "choroid blood vessel" EXACT [OBOL:automatic] synonym: "choroid blood vessels" EXACT [] synonym: "choroid blood vessels set" EXACT [] synonym: "choroid coat blood vessel" EXACT [OBOL:automatic] synonym: "choroidea blood vessel" EXACT [OBOL:automatic] synonym: "posterior uvea blood vessel" EXACT [OBOL:automatic] synonym: "set of choroid blood vessels" RELATED [FMA:76550] synonym: "vasa sanguinea choroideae" EXACT OMO:0003011 [FMA:76550, FMA:TA] xref: EMAPA:17828 xref: FMA:76550 xref: MA:0001237 is_a: UBERON:0003496 ! head blood vessel intersection_of: UBERON:0001981 ! blood vessel intersection_of: BFO:0000050 UBERON:0001776 ! part of optic choroid relationship: BFO:0000050 UBERON:0001776 ! part of optic choroid property_value: skos:prefLabel "choroidal blood vessel" xsd:string [Term] id: UBERON:0002444 name: lens fiber def: "A region of the lens consisting of packed elongated enucleate cells packed with crystallin." [http://orcid.org/0000-0002-6601-2165] subset: human_reference_atlas subset: pheno_slim synonym: "fibrae lentis" EXACT OMO:0003011 [FMA:76827, FMA:TA] synonym: "lens fibers" EXACT [] synonym: "lens fibers set" EXACT [] synonym: "lens fibre" RELATED [EMAPA:17841] synonym: "lens fibres" EXACT [] synonym: "set of lens fibers" RELATED [FMA:76827] xref: BTO:0000724 xref: CALOHA:TS-0544 xref: EHDAA:4745 xref: EHDAA:9065 xref: EMAPA:17841 xref: FMA:76827 xref: MA:0001304 xref: NCIT:C32976 xref: RETIRED_EHDAA2:0000979 xref: UMLS:C0229224 {source="ncithesaurus:Lens_Fiber"} xref: VHOG:0000444 xref: Wikipedia:Lens_(anatomy)#Lens_fibers xref: XAO:0004096 is_a: UBERON:0034944 ! zone of organ intersection_of: UBERON:0034944 ! zone of organ intersection_of: RO:0002473 CL:0011004 ! composed primarily of lens fiber cell relationship: BFO:0000050 UBERON:0000965 ! part of lens of camera-type eye relationship: RO:0002433 UBERON:0000965 ! contributes to morphology of lens of camera-type eye relationship: RO:0002473 CL:0011004 ! composed primarily of lens fiber cell property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0002446 name: patella def: "A large sesamoid bone found in the distal femur/proximal tibial region of the hindlimb of tetrapods. The patella is the attachment site for proximal hindlimb tendons.[PHENOSCAPE:ad]." [https://sourceforge.net/tracker/?func=detail&atid=1205376&aid=3470151&group_id=76834, PHENOSCAPE:ad] comment: The patella, also known as the knee cap or kneepan, is the largest sesamoid bone in the human body. The primary functional role of the patella is knee extension. The patella has convergently evolved in placental mammals and birds; marsupials have only rudimentary, non-ossified patellae. In more primitive tetrapods, including living amphibians and reptiles, the muscle tendons from the upper leg are attached directly to the tibia, and the patella is not present. See also: fabella. subset: human_reference_atlas subset: pheno_slim subset: uberon_slim synonym: "knee bone" RELATED [FMA:24485] synonym: "knee cap" RELATED [Wikipedia:Patella] synonym: "patella" RELATED OMO:0003011 [Wikipedia:Patella] xref: EMAPA:35668 xref: FMA:24485 xref: GAID:203 xref: galen:Patella xref: MA:0001374 xref: MESH:D010329 xref: NCIT:C33282 xref: SCTID:182083008 xref: UMLS:C0030647 {source="ncithesaurus:Patella"} xref: Wikipedia:Patella is_a: UBERON:0001479 {source="FMA"} ! sesamoid bone is_a: UBERON:0005893 ! leg bone is_a: UBERON:0011141 ! appendicular ossicle intersection_of: UBERON:0001474 ! bone element intersection_of: BFO:0000050 UBERON:0001465 ! part of knee intersection_of: RO:0002170 UBERON:0000981 ! connected to femur relationship: BFO:0000050 UBERON:0001465 ! part of knee relationship: RO:0002170 UBERON:0000981 ! connected to femur relationship: RO:0002220 UBERON:0001485 ! adjacent to knee joint property_value: foaf:depiction "https://upload.wikimedia.org/wikipedia/commons/9/9a/Knee_diagram.svg" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0002450 name: decidua def: "The maternal uterine-derived portion of the placenta." [MP:0004256, PMID:11433360] subset: pheno_slim subset: uberon_slim synonym: "decidous membrane" EXACT [FMA:85538] synonym: "decidua basalis" RELATED [] synonym: "endometrium" RELATED [] synonym: "extraembryonic part of placenta" RELATED [http://orcid.org/0000-0002-6601-2165] synonym: "extraembryonic placenta" RELATED [http://orcid.org/0000-0002-6601-2165] synonym: "maternal decidual layer" RELATED [MP:0004256] synonym: "maternal part of placenta" RELATED [http://orcid.org/0000-0002-6601-2165] synonym: "maternal placenta" RELATED [EMAPA:35269, GOC:dph] synonym: "placenta maternal decidual layer" RELATED [] synonym: "uterine decidua" RELATED [BTO:0001360] xref: BTO:0001360 xref: CALOHA:TS-0193 xref: EMAPA:35269 xref: FMA:85538 xref: GAID:378 xref: MA:0001722 xref: MAT:0000290 xref: MESH:D003656 xref: MIAA:0000290 xref: NCIT:C32425 xref: SCTID:362842004 xref: UMLS:C0011106 {source="ncithesaurus:Decidua"} xref: Wikipedia:Decidua is_a: BFO:0000002 is_a: UBERON:0000478 {source="FMA"} ! extraembryonic structure relationship: BFO:0000050 UBERON:0001987 ! part of placenta relationship: RO:0002202 UBERON:0000459 ! develops from uterine wall relationship: RO:0002433 UBERON:0001987 ! contributes to morphology of placenta property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/f/fa/Gray33.png" xsd:anyURI property_value: IAO:0000116 "TODO - check mp syn" xsd:string [Term] id: UBERON:0002451 name: endometrial gland def: "The mucous secreting gland associated with the mucuous membrane lining the uterus." [Wikipedia:Uterine_glands] subset: human_reference_atlas subset: organ_slim subset: pheno_slim subset: uberon_slim synonym: "endometrial gland" EXACT [BTO:0003433] synonym: "endometrial mucuous gland" EXACT [] synonym: "endometrium gland" EXACT [] synonym: "glandulae uterinae" EXACT OMO:0003011 [FMA:71647, FMA:TA] synonym: "glandulae uterinae" RELATED OMO:0003011 [Wikipedia:Uterine_glands] synonym: "uterine gland" EXACT [] xref: BTO:0003433 xref: BTO:0004518 xref: EMAPA:29919 xref: MA:0001726 xref: NCIT:C33842 xref: SCTID:361377009 xref: UMLS:C1183035 {source="ncithesaurus:Uterine_Gland"} xref: Wikipedia:Uterine_glands is_a: UBERON:0000414 {source="MP"} ! mucous gland is_a: UBERON:0005398 ! female reproductive gland intersection_of: UBERON:0002530 ! gland intersection_of: BFO:0000050 UBERON:0001295 ! part of endometrium relationship: BFO:0000050 UBERON:0012276 ! part of endometrium glandular epithelium relationship: RO:0000086 PATO:0002299 {source="Wikipedia:Tubular_gland"} ! has quality tubular property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/2/28/Gray1169.png" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0002456 name: internal thoracic artery def: "An artery that supplies the anterior chest wall and the breasts. It is a paired artery, with one running along each side of the sternum, to continue after its bifurcation as the superior epigastric and musculophrenic arteries. [WP,unvetted]." [Wikipedia:Internal_thoracic_artery] subset: human_reference_atlas subset: uberon_slim synonym: "arteria mammaria interna" RELATED OMO:0003011 [Wikipedia:Internal_thoracic_artery] synonym: "arteria thoracica interna" RELATED OMO:0003011 [Wikipedia:Internal_thoracic_artery] synonym: "internal mammary artery" EXACT PENDING_REVIEW [MA:0001982] synonym: "internal thoracic mammary artery" EXACT [] synonym: "mammary artery" RELATED [EMAPA:18617] xref: EHDAA2:0000880 xref: EHDAA:8585 xref: EMAPA:18617 xref: FMA:3960 xref: MA:0001982 xref: MA:0001984 xref: NCIT:C52941 xref: SCTID:244239009 xref: UMLS:C0226276 {source="ncithesaurus:Internal_Mammary_Artery"} xref: Wikipedia:Internal_thoracic_artery is_a: UBERON:0004573 ! systemic artery relationship: BFO:0000050 UBERON:0001533 ! part of subclavian artery relationship: RO:0002252 UBERON:0001533 ! connecting branch of subclavian artery relationship: RO:0020101 UBERON:0000310 ! vessel supplies blood to breast property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/5/5c/Gray522.png" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0002457 name: intersomitic artery def: "The small branching sprouts of the dorsal aorta that grow across the medial surface of the somite, turn right angles to grow over that surface and then fuse with other sprouts and form the vertebral arteries adjacent to the neural tube; the intersomitic arteries supply the body wall and persist in the adult as the posterior intercostal, subcostal and the lumbar arteries." [MP:0010662] subset: pheno_slim subset: vertebrate_core synonym: "intersegmental arteries" RELATED OMO:0003004 [ZFA:0001061] synonym: "intersegmental artery" EXACT [ZFA:0001061] xref: EHDAA2:0000882 xref: EHDAA:4340 xref: EMAPA:17616 xref: MA:0001985 xref: SCTID:360401001 xref: TAO:0001061 xref: VHOG:0000225 xref: XAO:0004165 xref: ZFA:0001061 is_a: UBERON:0001637 ! artery is_a: UBERON:0014907 ! intersomitic vessel property_value: skos:prefLabel "intersomitic artery" xsd:string [Term] id: UBERON:0002458 name: spinal artery def: "Arteries that supply the spinal cord." [https://orcid.org/0000-0002-6601-2165, Wikipedia:Spinal_artery] subset: uberon_slim subset: vertebrate_core synonym: "spinal arteries" EXACT OMO:0003004 [ZFA:0000682] xref: EHDAA2:0001890 xref: EHDAA:4355 xref: EMAPA:18241 xref: MA:0002043 xref: NCIT:C33587 xref: SCTID:244228006 xref: TAO:0000682 xref: UMLS:C0447043 {source="ncithesaurus:Spinal_Artery"} xref: Wikipedia:Spinal_artery xref: ZFA:0000682 is_a: UBERON:0004573 ! systemic artery intersection_of: UBERON:0001637 ! artery intersection_of: RO:0020101 UBERON:0002240 ! vessel supplies blood to spinal cord relationship: RO:0020101 UBERON:0002240 ! vessel supplies blood to spinal cord property_value: skos:prefLabel "spinal artery" xsd:string [Term] id: UBERON:0002460 name: vesical vein def: "A tributary of the iliac vein that drains the urinary bladder." [UBERON:cjm, Wikipedia:Vesical_veins] subset: human_reference_atlas subset: uberon_slim synonym: "venae vesicales" EXACT OMO:0003011 [FMA:70911, FMA:TA] synonym: "vesical veins" EXACT OMO:0003004 [] synonym: "vesical veins set" EXACT [] xref: EMAPA:37205 {source="MA:th"} xref: MA:0002263 xref: SCTID:12683000 xref: Wikipedia:Vesical_veins is_a: UBERON:0001638 ! vein intersection_of: UBERON:0001638 ! vein intersection_of: RO:0020102 UBERON:0001255 ! vessel drains blood from urinary bladder relationship: RO:0002376 UBERON:0001317 ! tributary of internal iliac vein relationship: RO:0020102 UBERON:0001255 ! vessel drains blood from urinary bladder property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/b/bd/Gray585.png" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0002464 name: nerve trunk synonym: "peripheral nerve trunk" EXACT [EMAPA:16986] synonym: "trunk of nerve" EXACT [] synonym: "trunk of peripheral nerve" EXACT [] xref: BTO:0000927 xref: EHDAA:4675 xref: EMAPA:16986 xref: FMA:14383 xref: FMA:5913 xref: MA:0000229 xref: MA:0002408 xref: SCTID:281248001 is_a: UBERON:0000122 ! neuron projection bundle intersection_of: UBERON:0000122 ! neuron projection bundle intersection_of: trunk_part_of UBERON:0001021 ! nerve disjoint_from: UBERON:0003439 ! nerve of trunk region relationship: trunk_part_of UBERON:0001021 ! nerve [Term] id: UBERON:0002465 name: lymphoid system def: "The lymphatic system in vertebrates is a network of conduits that carry a clear fluid called lymph. It also includes the lymphoid tissue through which the lymph travels. Lymphoid tissue is found in many organs, particularly the lymph nodes, and in the lymphoid follicles associated with the digestive system such as the tonsils. The system also includes all the structures dedicated to the circulation and production of lymphocytes, which includes the spleen, thymus, bone marrow and the lymphoid tissue associated with the digestive system[WP]." [Wikipedia:Lymphoid_system] subset: human_reference_atlas subset: uberon_slim subset: vertebrate_core synonym: "lymphatic circulatory system" RELATED [https://orcid.org/0000-0002-6601-2165] synonym: "lymphatic drainage system" RELATED [https://orcid.org/0000-0002-6601-2165] synonym: "lymphatic system" NARROW [ZFA:0000385] synonym: "systema lymphoideum" RELATED OMO:0003011 [Wikipedia:Lymphoid_system] xref: EHDAA2:0001043 xref: EHDAA:8677 xref: EMAPA:37664 {source="MA:th"} xref: FMA:74594 xref: GAID:931 xref: MA:0002435 xref: MAT:0000197 xref: MIAA:0000197 xref: NCIT:C12746 xref: SCTID:362589007 xref: TAO:0000385 xref: UMLS:C0024235 {source="ncithesaurus:Lymphatic_System"} xref: VHOG:0000842 xref: Wikipedia:Lymphoid_system xref: XAO:0003199 xref: ZFA:0000385 is_a: UBERON:0000467 ! anatomical system relationship: BFO:0000050 UBERON:0002193 {source="FMA"} ! part of hemolymphoid system relationship: BFO:0000050 UBERON:0002405 ! part of immune system relationship: RO:0002162 NCBITaxon:7711 ! in taxon Chordata property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/b/b3/TE-Lymphatic_system_diagram.svg" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0002466 name: intestine secretion def: "Clear to pale yellow watery secretions from the glands lining the small intestine walls. Secretion is stimulated by the mechanical pressure of partly digested food in the intestine." [Wikipedia:Succus_entericus] subset: pheno_slim subset: uberon_slim synonym: "intestinal juice" RELATED [BTO:0000644] synonym: "intestinal secretion" EXACT [FMA:62974] synonym: "succus entericus" EXACT [Wikipedia:Succus_entericus] xref: BTO:0000644 xref: FMA:62974 xref: GAID:1162 xref: MA:0002515 xref: MESH:D007419 xref: NCIT:C32875 xref: UMLS:C0021849 {source="ncithesaurus:Intestinal_Secretion"} xref: Wikipedia:Succus_entericus is_a: UBERON:0000456 ! secretion of exocrine gland intersection_of: UBERON:0000456 ! secretion of exocrine gland intersection_of: RO:0003001 UBERON:0000160 ! produced by intestine relationship: RO:0003001 UBERON:0000160 ! produced by intestine property_value: skos:prefLabel "intestine secretion" xsd:string [Term] id: UBERON:0002469 name: esophagus mucosa def: "A mucosa that is part of a esophagus [Automatically generated definition]." [OBOL:automatic] synonym: "esophageal mucosa" EXACT [] synonym: "esophageal mucous membrane" EXACT [] synonym: "esophagus mucosa" EXACT [FMA:62996] synonym: "esophagus mucous membrane" EXACT [OBOL:automatic] synonym: "lamina muscularis mucosae oesophageae" EXACT OMO:0003011 [FMA:62996, FMA:TA] synonym: "mucosa of esophagus" EXACT [OBOL:automatic] synonym: "mucosa of oesophagus" EXACT [OBOL:automatic] synonym: "mucous membrane of esophagus" EXACT [] synonym: "mucous membrane of oesophagus" EXACT [FMA:62996] synonym: "muscularis mucosae of oesophagus" RELATED INCONSISTENT [FMA:62996] synonym: "oesophageal mucosa" EXACT [FMA:62996] synonym: "oesophagus mucosa" EXACT [] synonym: "oesophagus mucous membrane" EXACT [OBOL:automatic] synonym: "tunica mucosa esophagi" EXACT [] synonym: "tunica mucosa oesophageae" EXACT OMO:0003011 [FMA:62996, FMA:TA] synonym: "tunica mucosa oesophagi" EXACT [] synonym: "tunica mucosa oesophagi" RELATED [BTO:0002859] xref: BTO:0002859 xref: EMAPA:26981 xref: FMA:62996 xref: MA:0002680 xref: NCIT:C32538 xref: SCTID:362127004 xref: UMLS:C0227176 {source="ncithesaurus:Esophageal_Mucosa"} is_a: UBERON:0000344 ! mucosa intersection_of: UBERON:0000344 ! mucosa intersection_of: BFO:0000050 UBERON:0001043 ! part of esophagus relationship: BFO:0000050 UBERON:0001096 ! part of wall of esophagus property_value: skos:prefLabel "esophagus mucosa" xsd:string [Term] id: UBERON:0002470 name: autopod region def: "Terminal segment of free limb, immediately distal to the zeugopod region. The fully developed autopod consists of the autopod skeleton plus associated structures such as integument, muscle tissue, vasculature etc. The autopod is divided into mesopodial, metapodiual, and acropodial segments. Examples: human hand, mouse paw, human foot." [https://github.com/obophenotype/uberon/issues/303, https://orcid.org/0000-0002-6601-2165] subset: efo_slim subset: pheno_slim subset: uberon_slim synonym: "autopod" BROAD [MA:0002714] synonym: "autopodial element" RELATED [] synonym: "autopodial limb segment" EXACT [MA:th] synonym: "autopodial segment" EXACT [] synonym: "autopodium" EXACT [] synonym: "autopodium region" EXACT [] synonym: "distal free limb segment" EXACT [FMA:83015] synonym: "distal segment of free limb" EXACT [FMA:83015] synonym: "distal segment of limb" RELATED [EMAPA:32722] synonym: "manus/pes" RELATED [] synonym: "paw" RELATED [] synonym: "paw/hand/foot/hoof" RELATED [] synonym: "pod" RELATED [] xref: BTO:0004359 xref: EFO:0000877 xref: EMAPA:32722 xref: FMA:83015 xref: MA:0002714 xref: MAT:0000091 xref: MIAA:0000091 xref: NCIT:C77660 xref: SCTID:95936004 xref: UMLS:C0687080 {source="ncithesaurus:Paw"} is_a: UBERON:0002529 ! limb segment intersection_of: UBERON:0002529 ! limb segment intersection_of: RO:0002551 UBERON:0006717 ! has skeleton autopodial skeleton relationship: distally_connected_to UBERON:0002471 ! zeugopod relationship: RO:0002202 UBERON:0010130 {evidence="definitional"} ! develops from embryonic autopod plate relationship: RO:0002433 UBERON:0002101 ! contributes to morphology of limb relationship: RO:0002551 UBERON:0006717 ! has skeleton autopodial skeleton [Term] id: UBERON:0002471 name: zeugopod def: "The middle free limb segment, between the autopod and stylopod segments. Includes as parts the zeugopodial skeleton. Examples: There are two types of zeugopod: forelimb zeugopod (aka forearm), hindlimb zeugopod (aka crus)." [https://github.com/obophenotype/uberon/issues/101, PHENOSCAPE:curators] comment: There exists some controversy about which podial segments are present in some fishes, e.g. if the autopod is not newly evolved in tetrapods, there is a question as to which segments are actually present in basal vertebrate taxa.[PHENOSCAPE:curators] subset: efo_slim subset: pheno_slim subset: uberon_slim synonym: "epipodium" EXACT [MA:th] synonym: "middle free limb segment" EXACT [FMA:83016] synonym: "middle limb segment" EXACT [] synonym: "middle part of limb" BROAD [] synonym: "middle segment of free limb" RELATED [FMA:83016] synonym: "zeugopod limb segment" EXACT [MA:th] synonym: "zeugopodial limb segment" EXACT [MA:th] synonym: "zeugopodium" EXACT [] synonym: "zygopod" EXACT [] synonym: "zygopodium" EXACT [] xref: EFO:0000878 xref: FMA:83016 xref: MA:0002716 xref: MAT:0000092 xref: MIAA:0000092 is_a: UBERON:0002529 ! limb segment intersection_of: UBERON:0002529 ! limb segment intersection_of: RO:0002551 UBERON:0011584 ! has skeleton zeugopodial skeleton relationship: BSPO:0000097 UBERON:0002472 ! stylopod relationship: BSPO:0000100 UBERON:0002470 ! autopod region relationship: RO:0002551 UBERON:0011584 ! has skeleton zeugopodial skeleton property_value: terms:contributor https://orcid.org/0000-0001-7972-3866 property_value: terms:contributor https://orcid.org/0000-0001-9114-8737 property_value: terms:contributor https://orcid.org/0000-0002-6601-2165 [Term] id: UBERON:0002472 name: stylopod def: "The proximal free limb segment. Includes as parts the stylopod skeleton." [http://orcid.org/0000-0002-6601-2165] subset: efo_slim subset: uberon_slim synonym: "propodium" EXACT [MA:th] synonym: "proximal free limb segment" EXACT [FMA:83014] synonym: "proximal part of limb" BROAD [] synonym: "proximal segment of free limb" RELATED [FMA:83014] synonym: "stylopodial limb segment" EXACT [MA:th] synonym: "stylopodium" EXACT [] xref: EFO:0000879 xref: FMA:83014 xref: MA:0002717 xref: MAT:0000093 xref: MIAA:0000093 is_a: UBERON:0002529 ! limb segment intersection_of: UBERON:0002529 ! limb segment intersection_of: RO:0002551 UBERON:0011583 ! has skeleton stylopodial skeleton relationship: BSPO:0000100 UBERON:0002471 ! zeugopod relationship: RO:0002551 UBERON:0011583 ! has skeleton stylopodial skeleton [Term] id: UBERON:0002473 name: intercerebral commissure def: "A commissure that connects the two cerebral hemispheres. Examples: anterior commissure, corpus callosum." [http://orcid.org/0000-0002-6601-2165] synonym: "commissure of cerebrum" RELATED [] synonym: "inter-hemispheric commissure" RELATED [] synonym: "interhemispheric commissure" RELATED [MA:0002721] xref: EMAPA:35435 xref: FMA:67930 xref: MA:0002721 xref: neuronames:1559 xref: SCTID:360567002 is_a: UBERON:0019294 ! commissure of telencephalon intersection_of: UBERON:0001020 ! nervous system commissure intersection_of: RO:0002176 UBERON:0002812 ! connects left cerebral hemisphere intersection_of: RO:0002176 UBERON:0002813 ! connects right cerebral hemisphere relationship: BFO:0000050 UBERON:0002437 ! part of cerebral hemisphere white matter relationship: RO:0002176 UBERON:0002812 ! connects left cerebral hemisphere relationship: RO:0002176 UBERON:0002813 ! connects right cerebral hemisphere property_value: skos:prefLabel "intercerebral commissure" xsd:string [Term] id: UBERON:0002474 name: cerebellar peduncular complex def: "A composite structure of the brain stem, which is subdivided into the superior cerebellar peduncle of pons, the decussation of superior cerebellar peduncle and the superior cerebellar peduncle of midbrain (MM)[NIF, based on NN]." [BIRNLEX:970] subset: uberon_slim synonym: "basal ganglia (anatomic)" RELATED [NeuroNames:224] synonym: "cerebellar peduncles" EXACT [] synonym: "cerebellar peduncles and decussations" EXACT [BIRNLEX:970] synonym: "cerebellar peduncles set" EXACT [] synonym: "cerebellum peduncles" EXACT [] synonym: "corpus striatum (Savel'ev)" RELATED OMO:0003011 [NeuroNames:224] synonym: "ganglia basales" RELATED OMO:0003011 [NeuroNames:224] synonym: "pedunculi cerebellares" EXACT OMO:0003011 [FMA:77791, FMA:TA] synonym: "set of cerebellar peduncles" RELATED [FMA:77791] xref: BAMS:cbp xref: BIRNLEX:970 xref: FMA:77791 xref: MBA:752 xref: neuronames:224 {source="BIRNLEX:970"} xref: UMLS:C0228514 {source="BIRNLEX:970"} xref: Wikipedia:Cerebellar_peduncle is_a: UBERON:0002616 ! regional part of brain relationship: BFO:0000050 UBERON:0002317 {source="NIF-isa"} ! part of white matter of cerebellum relationship: BFO:0000050 UBERON:0014891 {source="MA"} ! part of brainstem white matter property_value: IAO:0000116 "TODO - this requires work for making consistent with ABA, which strictly separates cerebellum from brainstem. in MA, cerebellar peduncle is part of both brainstem and cerebellar white matter." xsd:string property_value: skos:prefLabel "cerebellar peduncular complex" xsd:string [Term] id: UBERON:0002476 name: lateral globus pallidus def: "The more lateral of the two segments of the globus pallidus, abutting the putamen." [BIRNLEX:1610] subset: human_reference_atlas subset: uberon_slim synonym: "external globus pallidus" EXACT [] synonym: "external pallidum" EXACT [BIRNLEX:1610] synonym: "external part of globus pallidus" EXACT [BIRNLEX:1610] synonym: "globus pallidus (rat)" RELATED OMO:0003011 [NeuroNames:232] synonym: "globus pallidus extermal segment" EXACT [BIRNLEX:1610] synonym: "globus pallidus external segment" EXACT [BIRNLEX:1610, FMA:61839, MA:0002767] synonym: "globus pallidus externus" EXACT [] synonym: "globus pallidus lateral part" RELATED [BAMS:GPl] synonym: "globus pallidus lateral segment" RELATED [MA:0002767] synonym: "globus pallidus lateralis" EXACT [BTO:0002247] synonym: "globus pallidus, external segment" RELATED [NeuroNames:232] synonym: "globus pallidus, lateral part" RELATED [NeuroNames:232] synonym: "globus pallidus, lateral segment" EXACT [] synonym: "globus pallidus, pars externa" RELATED OMO:0003011 [NeuroNames:232] synonym: "lateral division of globus pallidus" RELATED [NeuroNames:232] synonym: "lateral pallidal segment" EXACT [] synonym: "lateral pallidum" EXACT [BIRNLEX:1610] synonym: "lateral part of globus pallidus" EXACT [] synonym: "lateral segment of globus pallidus" EXACT [BIRNLEX:1610] synonym: "lateral segment of the globus pallidus" RELATED [NeuroNames:232] synonym: "nucleus lateralis globi pallidi" RELATED OMO:0003011 [NeuroNames:232] synonym: "pallidum dorsal region external segment" RELATED [BAMS:GPe] synonym: "pallidum I" RELATED [BTO:0002247] synonym: "pallidus II" EXACT [FMA:61839] synonym: "pars lateralis globi pallidi medialis" EXACT OMO:0003011 [FMA:61839, FMA:TA] xref: BAMS:EGP xref: BAMS:GPe xref: BAMS:GPl xref: BAMS:LGP xref: BIRNLEX:1610 xref: BTO:0002247 xref: EHDAA2:0004462 xref: EMAPA:37638 {source="MA:th"} xref: FMA:61839 xref: HBA:12897 xref: MA:0002767 xref: MBA:1022 xref: neuronames:232 {source="BIRNLEX:1610"} xref: PBA:10099 xref: SCTID:361560008 xref: UMLS:C0262267 {source="BIRNLEX:1610"} xref: Wikipedia:Lateral_globus_pallidus is_a: UBERON:0005401 ! cerebral hemisphere gray matter disjoint_from: UBERON:0002477 {source="lexical"} ! medial globus pallidus relationship: BFO:0000050 UBERON:0001875 ! part of globus pallidus property_value: foaf:depiction "https://upload.wikimedia.org/wikipedia/commons/e/ee/Brain_structure.gif" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "lateral globus pallidus" xsd:string [Term] id: UBERON:0002477 name: medial globus pallidus def: "The more medial segment of the globus pallidus." [BIRNLEX:1555] comment: See also: endopeduncular nucleus subset: human_reference_atlas subset: uberon_slim synonym: "entopeduncular nucleus" RELATED [MA:0002768] synonym: "entopeduncular nucleus (monakow)" EXACT [FMA:61840] synonym: "globus pallidus inernal segment" RELATED [MA:0002768] synonym: "globus pallidus interna" EXACT OMO:0003011 [] synonym: "globus pallidus internal segment" EXACT [FMA:61840] synonym: "globus pallidus internus" EXACT OMO:0003011 [FMA:61840] synonym: "globus pallidus medial part" RELATED [BAMS:GPm] synonym: "globus pallidus medial segment" EXACT [FMA:61840] synonym: "globus pallidus medial segment" RELATED [MA:0002768] synonym: "globus pallidus medialis" EXACT OMO:0003011 [BTO:0002248, FMA:TA] synonym: "globus pallidus pars medialis" RELATED OMO:0003011 [NeuroNames:233] synonym: "globus pallidus, internal segment" RELATED [NeuroNames:233] synonym: "globus pallidus, medial part" RELATED [NeuroNames:233] synonym: "globus pallidus, medial segment" EXACT [FMA:61840] synonym: "globus pallidus, pars interna" RELATED OMO:0003011 [NeuroNames:233] synonym: "internal globus pallidus" EXACT [FMA:61840] synonym: "internal pallidum" EXACT [BIRNLEX:1555] synonym: "internal part of globus pallidus" EXACT [BIRNLEX:1555] synonym: "medial division of globus pallidus" RELATED [NeuroNames:233] synonym: "medial globus pallidus (entopeduncular nucleus)" RELATED [BAMS:MGP] synonym: "medial pallidal segment" EXACT [FMA:61840] synonym: "medial part of globus pallidus" EXACT [FMA:61840] synonym: "medial segment of globus pallidus" EXACT [BIRNLEX:1555] synonym: "medial segment of the globus pallidus" RELATED [NeuroNames:233] synonym: "mesial pallidum" EXACT [FMA:61840] synonym: "nucleus medialis globi pallidi" RELATED OMO:0003011 [NeuroNames:233] synonym: "pallidum dorsal region internal segment" RELATED [BAMS:GPi] synonym: "pallidum I" RELATED [] synonym: "pallidum II" RELATED [BTO:0002248] synonym: "pallidus I" EXACT [FMA:61840] synonym: "pallidus I" RELATED [] synonym: "pars medialis globi pallidi" EXACT OMO:0003011 [FMA:61840, FMA:TA] synonym: "principal medial geniculate nucleus" RELATED [BAMS:MGP] xref: BAMS:GPi xref: BAMS:GPm xref: BAMS:IGP xref: BAMS:MGP xref: BIRNLEX:1555 xref: BTO:0002248 xref: DHBA:10344 xref: DMBA:15830 xref: EMAPA:37639 {source="MA:th"} xref: FMA:61840 xref: HBA:12898 xref: MA:0002768 xref: MBA:1031 xref: neuronames:233 {source="BIRNLEX:1555"} xref: PBA:10098 xref: SCTID:361562000 xref: UMLS:C0262283 {source="BIRNLEX:1555"} xref: Wikipedia:Medial_globus_pallidus is_a: UBERON:0005401 ! cerebral hemisphere gray matter relationship: BFO:0000050 UBERON:0001875 {source="MA"} ! part of globus pallidus property_value: foaf:depiction "https://upload.wikimedia.org/wikipedia/commons/e/ee/Brain_structure.gif" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "medial globus pallidus" xsd:string [Term] id: UBERON:0002478 name: orbitosphenoid def: "The bone that is situated in the orbit on either side of the presphenoid; it generally forms a part of the sphenoid in the adult, and may be independent in the young." [ISBN:0-683-40008-8, MP:0004457] subset: pheno_slim subset: vertebrate_core synonym: "ala minor (os sphenoidale)" EXACT [FMA:52869] synonym: "ala minor ossis sphenoidalis" EXACT OMO:0003011 [FMA:52869, FMA:TA] synonym: "alae parvae" RELATED OMO:0003011 [Wikipedia:Lesser_wing_of_sphenoid_bone] synonym: "ingrassia's process" EXACT [FMA:52869] synonym: "lesser wing of sphenoid" EXACT [FMA:52869] synonym: "lesser wing of sphenoid bone" RELATED [MA:0002773] synonym: "lesser wing of sphenoidal bone" EXACT [FMA:52869] synonym: "orbitosphenoid bone" EXACT [http://orcid.org/0000-0002-6601-2165] synonym: "orbitosphenoids" RELATED OMO:0003004 [ZFA:0000253] xref: AAO:0000345 xref: EMAPA:18719 xref: FMA:52869 xref: MA:0002773 xref: SCTID:361737003 xref: TAO:0000253 xref: VHOG:0001153 xref: Wikipedia:Lesser_wing_of_sphenoid_bone xref: ZFA:0000253 is_a: UBERON:0002513 ! endochondral bone is_a: UBERON:0003462 ! facial bone is_a: UBERON:0011164 ! neurocranium bone is_a: UBERON:0015059 ! orbitosphenoid endochondral element is_a: UBERON:0015212 ! lateral structure intersection_of: UBERON:0015059 ! orbitosphenoid endochondral element intersection_of: RO:0002473 UBERON:0002481 ! composed primarily of bone tissue relationship: BFO:0000050 UBERON:0001677 ! part of sphenoid bone relationship: BSPO:0000126 UBERON:0002517 {source="FMA-abduced-lr"} ! basicranium relationship: RO:0002202 UBERON:0005687 ! develops from orbitosphenoid cartilage element relationship: RO:0002202 UBERON:0009638 ! develops from orbitosphenoid ossification center relationship: RO:0002433 UBERON:0001677 ! contributes to morphology of sphenoid bone property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/3/35/Gray145.png" xsd:anyURI property_value: skos:prefLabel "orbitosphenoid" xsd:string [Term] id: UBERON:0002479 name: dorsal lateral geniculate nucleus def: "The main division of the lateral geniculate body; consists of two magnocellular layers [TA] (strata magnocellularia [TA]) and four parvocellular layers [TA] (strata parvocellularia [TA]) and serves as a processing station in the major pathway from the retina to the cerebral cortex, receiving fibers from the optic tract and giving rise to the geniculocalcarine radiation to the visual cortex in the occipital lobe." [http://www.medilexicon.com/medicaldictionary.php?t=61422] synonym: "corpus geniculatum laterale (Hassler)" RELATED OMO:0003011 [NeuroNames:353] synonym: "DLG" BROAD OMO:0003000 [BIRNLEX:1595, NIFSTD:NeuroNames_abbrevSource] synonym: "dorsal nucleus of lateral geniculate body" RELATED [MA:0002775] synonym: "dorsal part of the lateral geniculate complex" RELATED [NeuroNames:353] synonym: "lateral geniculate complex, dorsal part" EXACT [] synonym: "lateral geniculate nucleus dorsal part" RELATED [BAMS:LGd] synonym: "lateral geniculate nucleus, dorsal part" EXACT [NeuroNames:353] synonym: "nucleus corporis geniculati lateralis, pars dorsalis" RELATED OMO:0003011 [NeuroNames:353] synonym: "nucleus dorsalis corporis geniculati lateralis" EXACT OMO:0003011 [FMA:62214, FMA:TA] synonym: "nucleus geniculatus lateralis dorsalis" RELATED OMO:0003011 [NeuroNames:353] synonym: "nucleus geniculatus lateralis pars dorsalis" EXACT [BIRNLEX:1595] xref: BAMS:DLG xref: BAMS:LGd xref: BIRNLEX:1595 xref: BM:GLd xref: DHBA:10430 xref: DMBA:16436 xref: EMAPA:35290 xref: FMA:62214 xref: HBA:4440 xref: MA:0002775 xref: MBA:170 xref: neuronames:353 {source="BIRNLEX:1595"} xref: PBA:128013074 xref: UMLS:C0175292 {source="BIRNLEX:1595"} is_a: UBERON:0015233 ! nucleus of dorsal thalamus relationship: BFO:0000050 UBERON:0001926 ! part of lateral geniculate body relationship: BFO:0000050 UBERON:0002104 {source="NIFSTD"} ! part of visual system property_value: skos:prefLabel "dorsal lateral geniculate nucleus" xsd:string [Term] id: UBERON:0002481 name: bone tissue def: "Skeletal tissue with a collagen-rich extracellular matrix vascularized, mineralized with hydroxyapatite and typically including osteocytes located in lacunae that communicate with one another by cell processes (in canaliculi). Bone is deposited by osteoblasts." [GO_REF:0000034, http://dx.plos.org/10.1371/journal.pone.0051070, PSPUB:0000170, VSAO:0000047] subset: pheno_slim subset: uberon_slim synonym: "bone" RELATED [MESH:A02.835.232] synonym: "calcium tissue" EXACT [] synonym: "mineralized bone tissue" NARROW [XAO:0004040] synonym: "osseous tissue" EXACT [] synonym: "osteogenic tissue" EXACT [VSAO:curator] synonym: "portion of bone tissue" RELATED [FMA:224804] xref: CALOHA:TS-2011 xref: EMAPA:35179 xref: FMA:224804 xref: galen:BoneTissue xref: MA:0002780 xref: MESH:D001842 xref: NCIT:C13076 xref: UMLS:C0391978 {source="ncithesaurus:Bone_Tissue"} xref: VSAO:0000047 xref: Wikipedia:Bone_tissue xref: XAO:0004040 xref: ZFA:0005621 is_a: UBERON:0004755 {source="VSAO"} ! skeletal tissue disjoint_from: UBERON:0005090 ! muscle structure relationship: BFO:0000050 UBERON:0001474 ! part of bone element property_value: IAO:0000116 "see https://github.com/obophenotype/uberon/issues/27" xsd:string property_value: skos:prefLabel "bone tissue" xsd:string [Term] id: UBERON:0002482 name: lamellar bone def: "Bone tissue that has a regular parallel alignment of collagen into sheets (lamellae) and is mechanically strong." [Wikipedia:Bone#Woven_or_lamellar] comment: histological classification, lamellar vs woven. Note that only FMA has woven xref: EMAPA:37625 {source="MA:th"} xref: FMA:224806 xref: galen:LamellarBone xref: MA:0002781 xref: Wikipedia:Bone#Woven_or_lamellar is_a: UBERON:0002481 ! bone tissue [Term] id: UBERON:0002484 name: bone marrow cavity def: "The medullary cavities of the bones where bone marrow is stored." [ISBN:0-683-40008-8, MP:0000065, PMID:10709991] subset: pheno_slim synonym: "cavity of cancellous bone" EXACT [] synonym: "marrow cavity" EXACT [FMA:83698] synonym: "medullary cavity" EXACT [FMA:83698] xref: FMA:75147 xref: FMA:83698 xref: MA:0002783 xref: Wikipedia:Bone_marrow_of_ovaryry_cavity is_a: UBERON:0002553 ! anatomical cavity relationship: BFO:0000050 UBERON:0001439 ! part of compact bone tissue relationship: RO:0002221 UBERON:0002371 ! surrounds bone marrow [Term] id: UBERON:0002485 name: prostate duct def: "The minute canals that pass the prostatic secretions to the urethra." [MP:0009734] subset: pheno_slim synonym: "duct of prostate" EXACT [] synonym: "duct of prostate gland" EXACT [] synonym: "prostate duct" EXACT [] synonym: "prostate gland duct" EXACT [] synonym: "prostatic duct" EXACT [] xref: EMAPA:36568 xref: FMA:19580 xref: MA:0002785 xref: NCIT:C13102 xref: SCTID:362276000 xref: UMLS:C0227965 {source="ncithesaurus:Prostatic_Duct"} xref: Wikipedia:Prostatic_ducts is_a: UBERON:0004119 ! endoderm-derived structure is_a: UBERON:0005904 ! duct of male reproductive system intersection_of: UBERON:0000058 ! duct intersection_of: BFO:0000050 UBERON:0002367 ! part of prostate gland relationship: BFO:0000050 UBERON:0002367 ! part of prostate gland relationship: RO:0002202 UBERON:0003820 {source="PMID:18977204"} ! develops from prostate bud relationship: RO:0002433 UBERON:0002367 ! contributes to morphology of prostate gland property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/prostate-male/v1.2/assets/3d-vh-m-prostate.glb" xsd:anyURI [Term] id: UBERON:0002490 name: frontal suture def: "A suture that connects the two frontal bones of the skull." [http://orcid.org/0000-0002-6601-2165] subset: pheno_slim subset: uberon_slim synonym: "frontal suture of skull" EXACT [] synonym: "median frontal suture" EXACT [] synonym: "metopic suture" RELATED [MA:0002796] synonym: "sutura frontalis" EXACT [Wikipedia:Frontal_suture] synonym: "sutura frontalis" RELATED OMO:0003011 [Wikipedia:Frontal_suture] synonym: "sutura metopica" EXACT OMO:0003011 [FMA:52989, FMA:TA] xref: EMAPA:19226 xref: EMAPA:35358 xref: FMA:52989 xref: MA:0002796 xref: SCTID:136854008 xref: Wikipedia:Frontal_suture is_a: UBERON:0003685 ! cranial suture intersection_of: UBERON:0003685 ! cranial suture intersection_of: RO:0002176 UBERON:0000209 {cardinality="2"} ! connects tetrapod frontal bone relationship: RO:0002176 UBERON:0000209 ! connects tetrapod frontal bone property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/1/17/Gray134.png" xsd:anyURI property_value: foaf:depiction "https://upload.wikimedia.org/wikipedia/commons/d/d1/Frontal_suture.png" xsd:anyURI property_value: skos:prefLabel "frontal suture" xsd:string [Term] id: UBERON:0002495 name: long bone def: "A long bone is a bone that has a shaft and 2 ends and is longer than it is wide. Long bones have a thick outside layer of compact bone and an inner medullary cavity containing bone marrow. The ends of a long bone contain spongy bone and an epiphyseal plate or line depending on the stage of development. The epiphyseal plate is a hyaline cartilage, where new bone growth takes place, lengthening the bone prior to adulthood. Bone lengthening ceases when this cartilage is lost, leaving a remnant referred to as an epiphyseal line." [https://medlineplus.gov/ency/imagepages/9582.htm, Wikipedia:Long_bone] {seeAlso="https://github.com/obophenotype/uberon/issues/32", seeAlso="https://github.com/obophenotype/uberon/issues/2010"} comment: Endochondral_ossification is an essential process during the rudimentary formation of long bones, with the exception of the clavicle[Wikipedia:Endochondral_ossification]. The medial and and lateral ends undergo EO, the mid-portion is formed by a process with features of EO & IO (the process is shared by the mandible)[ISBN:9780397517251] subset: pheno_slim subset: uberon_slim synonym: "os longum" RELATED [BTO:0004256] xref: BTO:0004256 xref: EMAPA:35503 xref: FMA:7474 xref: galen:LongBone xref: MA:0002802 xref: NCIT:C33003 xref: SCTID:332709000 xref: UMLS:C0222647 {source="ncithesaurus:Long_Bone"} xref: Wikipedia:Long_bone is_a: UBERON:0001474 ! bone element relationship: BFO:0000050 UBERON:0002091 ! part of appendicular skeleton relationship: RO:0002433 UBERON:0002091 ! contributes to morphology of appendicular skeleton property_value: terms:contributor https://orcid.org/0000-0002-6601-2165 property_value: terms:contributor https://orcid.org/0000-0003-3162-7490 [Term] id: UBERON:0002497 name: acromion def: "Region of the scapula where the latter meets with the clavicle: attachment point of the clavicle to the scapula in some taxa." [VSAO:0005067] subset: pheno_slim subset: uberon_slim synonym: "acromion of scapula" RELATED [Wikipedia:Acromion] synonym: "acromion of the scapula" RELATED [Wikipedia:Acromion] synonym: "acromion process" EXACT [VSAO:0005067] synonym: "scapular acromion" EXACT [VSAO:0005067] xref: AAO:0000826 xref: EMAPA:25119 xref: FMA:23260 xref: GAID:187 xref: MA:0002805 xref: MESH:D000174 xref: NCIT:C32048 xref: SCTID:181911000 xref: UMLS:C0001209 {source="ncithesaurus:Acromion"} xref: VSAO:0005067 xref: Wikipedia:Acromion is_a: UBERON:0004530 ! bony projection relationship: BFO:0000050 UBERON:0006849 ! part of scapula property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/7/79/Gray206.png" xsd:anyURI [Term] id: UBERON:0002498 name: deltopectoral crest def: "A rough elevation at the middle of the lateral side of the shaft of the humerus to which the deltoid muscle attaches." [ISBN:0-683-40008-8, MP:0004353] subset: pheno_slim subset: uberon_slim synonym: "crista ventralis" EXACT [AAO:0000736] synonym: "crista ventralis humeri" RELATED [AAO:0000736] synonym: "deltoid crest" EXACT [AAO:0000736, MP:0004353] synonym: "deltoid eminence" EXACT [MP:0004353] synonym: "deltoid impression" EXACT [MP:0004353] synonym: "deltoid process" RELATED [MP:0004353] synonym: "deltoid tuberosity" EXACT [FMA:23418] synonym: "deltoid tuberosity of humerus" EXACT [FMA:23418] synonym: "pectoral process" RELATED [] synonym: "tuberositas deltoidea" EXACT OMO:0003011 [FMA:23418, FMA:TA] synonym: "tuberositas deltoidea (corpus humeri)" EXACT [] synonym: "tuberositas deltoidea humeri" EXACT OMO:0003011 [Wikipedia:Deltoid_tuberosity] xref: AAO:0000736 xref: EMAPA:25052 xref: FMA:23418 xref: MA:0002808 xref: Wikipedia:Deltoid_tuberosity is_a: UBERON:0005813 ! tubercle is_a: UBERON:4100000 ! skeletal element projection relationship: BFO:0000050 UBERON:0004652 ! part of humerus diaphysis relationship: RO:0002433 UBERON:0000976 ! contributes to morphology of humerus property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/a/a7/HumerusFront.png" xsd:anyURI [Term] id: UBERON:0002499 name: cochlear labyrinth def: "The labyrinth is a system of fluid passages in the inner ear, including both the cochlea, which is part of the auditory system, and the vestibular system, which provides the sense of balance. It is named by analogy with the mythical maze that imprisoned the Minotaur, because of its appearance. The bony labyrinth, or osseous labyrinth, is the network of passages with bony walls lined with periosteum. The bony labyrinth is lined with the membranous labyrinth. There is a layer of perilymph between them. The three parts of the bony labyrinth are the vestibule of the ear, the semicircular canals, and the cochlea. The vestibular system is the region of the inner ear where the semicircular canals converge, close to the cochlea (the hearing organ). The vestibular system works with the visual system to keep objects in focus when the head is moving. Joint and muscle receptors also are important in maintaining balance. The brain receives, interprets, and processes the information from these systems that control our balance. [WP,unvetted]." [Wikipedia:Cochlear_labyrinth] subset: pheno_slim subset: uberon_slim xref: BTO:0004686 xref: EMAPA:36569 xref: FMA:61259 xref: MA:0002809 xref: NCIT:C32336 xref: UMLS:C0931689 {source="ncithesaurus:Cochlear_Labyrinth"} xref: Wikipedia:Cochlear_labyrinth is_a: UBERON:0000064 ! organ part relationship: BFO:0000050 UBERON:0001849 {source="FMA"} ! part of membranous labyrinth relationship: RO:0001025 UBERON:0001844 ! located in cochlea property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/1/19/Gray923.png" xsd:anyURI property_value: IAO:0000116 "we follow the FMA in placing this in the membranous labyrinth. Notes: The labyrinth can be divided by layer or by region. Bony vs. membranous / Vestibular vs. cochlear" xsd:string [Term] id: UBERON:0002506 name: iris epithelium def: "An epithelium that is part of a iris [Automatically generated definition]." [OBOL:automatic] subset: human_reference_atlas subset: pheno_slim synonym: "epithelial tissue of iris" EXACT [OBOL:automatic] synonym: "epithelium of iris" EXACT [OBOL:automatic] synonym: "epithelium pigmentosum (iris)" EXACT [FMA:58517] synonym: "epithelium pigmentosum iridis" EXACT OMO:0003011 [FMA:58517, FMA:TA] synonym: "iris epithelial tissue" EXACT [OBOL:automatic] synonym: "iris epithelium" EXACT [FMA:58517] synonym: "iris pigmented epithelium" RELATED [MA:0002826] synonym: "pigmented epithelium of iris" EXACT [FMA:58517] xref: EMAPA:35447 xref: FMA:58517 xref: MA:0002826 is_a: UBERON:0000488 {source="FMA"} ! atypical epithelium is_a: UBERON:0015808 ! eye epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: BFO:0000050 UBERON:0001769 ! part of iris relationship: BFO:0000050 UBERON:0001769 {source="MA"} ! part of iris relationship: BFO:0000051 GO:0048770 {source="MP"} ! has part pigment granule relationship: RO:0002433 UBERON:0001769 ! contributes to morphology of iris property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "iris epithelium" xsd:string [Term] id: UBERON:0002507 name: abdominal lymph node def: "A lymph node that is part of an abdomen [Automatically generated definition]." [OBOL:automatic] subset: pheno_slim synonym: "abdomen lymph node" EXACT [OBOL:automatic] synonym: "lymph node of abdomen" EXACT [] synonym: "parietal abdominal lymph node" RELATED [FMA:12787] xref: EMAPA:35992 xref: FMA:12787 xref: MA:0002827 xref: SCTID:245342005 is_a: UBERON:0000029 ! lymph node is_a: UBERON:0005172 ! abdomen element intersection_of: UBERON:0000029 ! lymph node intersection_of: BFO:0000050 UBERON:0000916 ! part of abdomen [Term] id: UBERON:0002509 name: mesenteric lymph node def: "The lymph nodes located in the mesentery, of which there are 3 classes: ileocolic, juxtaintestinal mesenteric, and central superior group." [MP:0005232] subset: human_reference_atlas subset: pheno_slim synonym: "mesenteric node" EXACT [] synonym: "nodi lymphoidei mesenterici" RELATED OMO:0003011 [BTO:0000767] xref: BTO:0000767 xref: EMAPA:35561 xref: FMA:12795 xref: MA:0002829 xref: NCIT:C77641 xref: UMLS:C0229792 {source="ncithesaurus:Mesenteric_Lymph_Node"} xref: Wikipedia:Mesenteric_lymph_nodes is_a: UBERON:0015860 {source="FMA"} ! visceral abdominal lymph node intersection_of: UBERON:0002507 ! abdominal lymph node intersection_of: BFO:0000050 UBERON:0002095 ! part of mesentery relationship: BFO:0000050 UBERON:0002095 ! part of mesentery property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/lymph-node-female/v1.4/assets/3d-nih-f-lymph-node.glb" xsd:anyURI property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/lymph-node-male/v1.4/assets/3d-nih-m-lymph-node.glb" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0002511 name: trabecula carnea def: "The supporting bundles of muscular fibers lining the walls of the ventricles of the heart." [MGI:monikat, MP:0004067] subset: pheno_slim synonym: "cardiac trabecula" RELATED [GO:0060347] synonym: "columnae carneae" RELATED OMO:0003011 [Wikipedia:Trabeculae_carneae] synonym: "heart trabecula" RELATED [GO:0060347] synonym: "trabecula of heart" RELATED [] synonym: "trabeculae carneae" RELATED OMO:0003004 [] synonym: "trabeculae carneae cordis" RELATED OMO:0003011 [Wikipedia:Trabeculae_carneae] synonym: "ventricle trabecula carnea" EXACT [MA:0002831] synonym: "ventricular trabecula" RELATED [MA:0002831] xref: EMAPA:18626 xref: FMA:7269 xref: MA:0002831 xref: SCTID:118755002 xref: Wikipedia:Trabeculae_carneae is_a: BFO:0000002 is_a: UBERON:0000440 ! trabecula relationship: BFO:0000050 UBERON:0002082 {source="WP"} ! part of cardiac ventricle relationship: RO:0002473 UBERON:0001133 ! composed primarily of cardiac muscle tissue [Term] id: UBERON:0002512 name: corpus luteum def: "A transient endocrine gland that develops from the postovulatory or atretic follicles and secretes progesterone; it is thought to be related to egg retention[PMID]." [PMID:20959416, Wikipedia:Corpus_luteum] subset: human_reference_atlas subset: pheno_slim subset: uberon_slim synonym: "corpora lutea" EXACT OMO:0003004 [] synonym: "corpus luteum of ovary" EXACT [] synonym: "luteal gland" RELATED [BTO:0000292] synonym: "ovarian corpus luteum" EXACT [] xref: BTO:0000292 xref: CALOHA:TS-0181 xref: EMAPA:29886 xref: FMA:18619 xref: GAID:369 xref: MA:0002834 xref: MESH:D003338 xref: NCIT:C26465 xref: SCTID:257943001 xref: UMLS:C0010092 {source="ncithesaurus:Corpus_Luteum"} xref: Wikipedia:Corpus_luteum is_a: UBERON:0002368 {source="PMID:20959416"} ! endocrine gland is_a: UBERON:0003134 ! female reproductive organ is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0005398 ! female reproductive gland relationship: BFO:0000050 UBERON:0000992 {source="MA"} ! part of ovary relationship: BFO:0000051 CL:0000175 ! has part luteal cell relationship: RO:0002202 UBERON:0001305 ! develops from ovarian follicle relationship: RO:0002215 GO:0042701 ! capable of progesterone secretion property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/5/57/Folliclesinovary.jpg" xsd:anyURI property_value: RO:0002175 NCBITaxon:7762 {source="PMID:20959416"} property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0002513 name: endochondral bone def: "Replacement bone that forms within cartilage." [GO:0001958, GO_REF:0000034, http://dx.plos.org/10.1371/journal.pone.0051070, https://github.com/obophenotype/uberon/issues/54, VSAO:0000145] subset: uberon_slim subset: vertebrate_core synonym: "cartilaginous bone" RELATED [BTO:0002157] synonym: "endochondral bones" RELATED OMO:0003004 [ZFA:0001591] synonym: "ossified chondrogenic bone" EXACT [VSAO:0000145] xref: AAO:0010776 xref: AEO:0000083 xref: BTO:0002157 xref: EHDAA2:0003083 xref: FMA:24321 xref: TAO:0001591 xref: VSAO:0000145 xref: XAO:0004018 xref: ZFA:0001591 is_a: UBERON:0001474 ! bone element is_a: UBERON:0010363 {source="VSAO"} ! endochondral element intersection_of: UBERON:0001474 ! bone element intersection_of: RO:0002202 UBERON:0005863 ! develops from cartilaginous condensation relationship: RO:0002202 UBERON:0007844 {source="VSAO"} ! develops from cartilage element relationship: RO:0002285 UBERON:0002418 ! developmentally replaces cartilage tissue property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/e/ee/Hypertrophic_Zone_of_Epiphyseal_Plate.jpg" xsd:anyURI property_value: IAO:0000116 "placement in this class to be inferred" xsd:string property_value: seeAlso "https://github.com/obophenotype/uberon/wiki/Modeling-endochondral-elements-Design-Pattern" xsd:anyURI property_value: skos:prefLabel "endochondral bone" xsd:string property_value: terms:contributor https://orcid.org/0000-0001-9114-8737 property_value: terms:contributor https://orcid.org/0000-0002-6601-2165 property_value: terms:contributor https://orcid.org/0000-0003-3162-7490 [Term] id: UBERON:0002514 name: intramembranous bone def: "Bone tissue forms directly within mesenchyme, and does not replace other tissues[TAO]. Intramembranous ossification is the formation of bone in which osteoblasts secrete a collagen-proteoglycan matrix that binds calcium salts and becomes calcified[GO]. Intramembranous ossification is the way flat bones and the shell of a turtle are formed[GO]. Unlike endochondral ossification, cartilage is not present during intramembranous ossification[WP]." [GO:0001957, https://github.com/obophenotype/uberon/issues/267, Wikipedia:Intramembranous_ossification] synonym: "intramembranous bones" RELATED OMO:0003004 [ZFA:0001635] synonym: "membrane bone" RELATED [AEO:0000085] xref: EMAPA:36615 xref: TAO:0001644 xref: Wikipedia:Intramembranous_ossification xref: ZFA:0001635 is_a: UBERON:0001474 {source="VSAO"} ! bone element relationship: RO:0002202 UBERON:0003104 ! develops from mesenchyme relationship: RO:0002353 GO:0001957 ! output of intramembranous ossification property_value: skos:prefLabel "intramembranous bone" xsd:string [Term] id: UBERON:0002515 name: periosteum def: "The thick fibrous membrane that closely invests the entire surface of a bone except the articular cartilage at synovial joints." [ISBN:0-683-40008-8, MP:0010971] subset: pheno_slim subset: uberon_slim xref: BTO:0001022 xref: EMAPA:35681 xref: FMA:24041 xref: GAID:925 xref: galen:PeriOsteum xref: MA:0002838 xref: MESH:D010521 xref: NCIT:C13184 xref: SCTID:33840008 xref: UMLS:C0031110 {source="ncithesaurus:Periosteum"} xref: Wikipedia:Periosteum is_a: UBERON:0000158 ! membranous layer relationship: BFO:0000050 UBERON:0001474 ! part of bone element relationship: RO:0002473 UBERON:0011822 ! composed primarily of dense irregular connective tissue property_value: foaf:depiction "https://upload.wikimedia.org/wikipedia/commons/c/cf/Bone_growth.png" xsd:anyURI [Term] id: UBERON:0002517 name: basicranium def: "The base of skull is the most inferior area of the skull, composed of the endocranium and lower parts of the skull roof." [Wikipedia:Base_of_skull] comment: The skull base is formed from a series of cartilages either side of, and rostral to, the notochord, whose tip lies just caudal to the pituitary gland. It is closely associated with the sensory capsules, which partially or completely sur- round the olfactory epithelium, the eye, and the inner ear[PMID:11523816] subset: pheno_slim subset: uberon_slim synonym: "base of cranium" EXACT [] synonym: "base of skull" EXACT [FMA:52801] synonym: "basis cranii" EXACT OMO:0003011 [FMA:52801, FMA:TA, Wikipedia:Base_of_skull] synonym: "cranial base" EXACT [FMA:52801, MA:0002840] xref: FMA:52801 xref: MA:0002840 xref: MESH:D019291 xref: MFMO:0000044 xref: NCIT:C12493 xref: SCTID:181890004 xref: UMLS:C0149543 {source="ncithesaurus:Base_of_the_Skull"} xref: Wikipedia:Base_of_skull is_a: UBERON:0000075 ! subdivision of skeletal system relationship: BFO:0000050 UBERON:0001703 ! part of neurocranium relationship: BFO:0000050 UBERON:0002241 ! part of chondrocranium relationship: RO:0002433 UBERON:0003128 ! contributes to morphology of cranium property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/8/81/Gray193.png" xsd:anyURI property_value: skos:prefLabel "basicranium" xsd:string [Term] id: UBERON:0002518 name: otolith organ def: "The crystalline particles composed of calcium carbonate and a protein which adhere to the gelatinous membrane of the maculae of the utricle and saccule (otolithic membrane)." [ISBN:0-683-40008-8, MGI:llw2, MP:0002894] subset: efo_slim subset: organ_slim subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "otolith organs" RELATED [ZFA:0000559] synonym: "saccule and utricle" RELATED [MESH:A09.246.631.909.625] synonym: "utricle and saccule" RELATED [MESH:A09.246.631.909.625] xref: EFO:0003539 xref: GAID:883 xref: MA:0002841 xref: MESH:D012444 xref: TAO:0000559 xref: VHOG:0001676 xref: Wikipedia:Otolith_organ xref: ZFA:0000559 is_a: BFO:0000002 is_a: UBERON:0006585 ! vestibular organ relationship: BFO:0000050 UBERON:0001862 ! part of vestibular labyrinth relationship: RO:0002202 UBERON:0003051 ! develops from ear vesicle relationship: RO:0002216 GO:0060007 ! capable of part of linear vestibuloocular reflex property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/c/cb/Bigotolith.jpg" xsd:anyURI property_value: IAO:0000116 "Representation of utricle, sacule and otoliths in correspondence to other ontologies may require review. In EHDAA2, saccule and utricle are epithelia" xsd:string [Term] id: UBERON:0002521 name: elastic tissue def: "Connective tissue composed of elastic fibers." [http://orcid.org/0000-0002-6601-2165] subset: uberon_slim synonym: "elastic connective tissue" EXACT [] synonym: "elastic fiber" NARROW [] synonym: "textus connectivus elasticus" EXACT OMO:0003011 [] xref: FMA:20113 xref: GAID:926 xref: MA:0002853 xref: MESH:D004547 xref: NCIT:C32495 xref: SCTID:27197004 xref: Wikipedia:Elastic_fiber is_a: UBERON:0002384 ! connective tissue intersection_of: UBERON:0002384 ! connective tissue intersection_of: RO:0002473 GO:0071953 ! composed primarily of elastic fiber relationship: RO:0000086 PATO:0001171 ! has quality elastic relationship: RO:0002473 GO:0071953 ! composed primarily of elastic fiber property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/c/cb/Gray377.png" xsd:anyURI property_value: skos:prefLabel "elastic tissue" xsd:string [Term] id: UBERON:0002522 name: tunica media def: "The middle layer of an artery or vein. [WP,unvetted]." [Wikipedia:Tunica_media] comment: May be composed of smooth muscle and elastic tissue subset: uberon_slim synonym: "tunica media vasorum" RELATED OMO:0003011 [BTO:0002011, Wikipedia:Tunica_media] xref: BTO:0002011 xref: EMAPA:36298 xref: FMA:55590 xref: GAID:170 xref: MA:0002855 xref: MESH:D017540 xref: NCIT:C33821 xref: SCTID:61695000 xref: UMLS:C0162867 {source="ncithesaurus:Tunica_Media"} xref: Wikipedia:Tunica_media is_a: BFO:0000002 is_a: UBERON:0004797 {source="MA"} ! blood vessel layer relationship: BFO:0000051 UBERON:0002521 {source="cjm"} ! has part elastic tissue relationship: BFO:0000051 UBERON:0004237 {source="cjm"} ! has part blood vessel smooth muscle relationship: RO:0002219 UBERON:0005734 ! surrounded by tunica adventitia of blood vessel property_value: foaf:depiction "https://upload.wikimedia.org/wikipedia/commons/3/32/Illu_artery.jpg" xsd:anyURI property_value: skos:prefLabel "tunica media" xsd:string [Term] id: UBERON:0002523 name: tunica intima def: "The innermost layer of a blood vessel which is a lining of endothelial cells facing the lumen[Kardong]." [ISBN:0073040584, NCIT:C33820, Wikipedia:Tunica_intima] subset: uberon_slim synonym: "Bichat's tunic" RELATED [BTO:0002012] synonym: "intima" RELATED [BTO:0002012] synonym: "tunica intima vasorum" RELATED [BTO:0002012] xref: BTO:0002012 xref: EMAPA:36297 xref: FMA:55589 xref: GAID:523 xref: MA:0002861 xref: MESH:D017539 xref: NCIT:C33820 xref: SCTID:8361002 xref: SCTID:87483006 xref: UMLS:C0162864 {source="ncithesaurus:Tunica_Intima"} xref: Wikipedia:Tunica_intima is_a: BFO:0000002 is_a: UBERON:0004923 {source="FMA"} ! organ component layer relationship: BFO:0000051 UBERON:0001986 ! has part endothelium relationship: RO:0002219 UBERON:0002522 ! surrounded by tunica media relationship: RO:0002220 UBERON:0010161 {source="ISBN:0073040584"} ! adjacent to lumen of blood vessel property_value: foaf:depiction "https://upload.wikimedia.org/wikipedia/commons/3/32/Illu_artery.jpg" xsd:anyURI property_value: IAO:0000116 "the FMA class represents a more generic layer which is the superclass of the layer found in both blood vessels and lymph vessels (and also endocardium) - we should probably follow this structure" xsd:string property_value: IAO:0000116 "the FMA class represents a structure which may have both epithelium and fibroelastic connective tissue as parts" xsd:string property_value: skos:prefLabel "tunica intima" xsd:string [Term] id: UBERON:0002527 name: pancreatic lymph node def: "A lymph node that is part of a pancreas [Automatically generated definition]." [OBOL:automatic] synonym: "aJCC level 19 node" RELATED [FMA:16626] synonym: "lymph node of pancreas" EXACT [OBOL:automatic] synonym: "pancreas lymph node" EXACT [OBOL:automatic] synonym: "pancreatic node" EXACT [] synonym: "pyloric lymph node" RELATED INCONSISTENT [MA:0002881] xref: FMA:16626 xref: MA:0002881 xref: NCIT:C77642 xref: SCTID:276170003 xref: UMLS:C0229783 {source="ncithesaurus:Pancreatic_Lymph_Node"} is_a: UBERON:0002507 ! abdominal lymph node intersection_of: UBERON:0000029 ! lymph node intersection_of: BFO:0000050 UBERON:0001264 ! part of pancreas relationship: BFO:0000050 UBERON:0001264 ! part of pancreas [Term] id: UBERON:0002528 name: sacral lymph node def: "A lymph node located in the sacral region." [ncithesaurus:Sacral_Lymph_Node] synonym: "sacral node" EXACT [] xref: FMA:16655 xref: MA:0002883 xref: NCIT:C77647 xref: SCTID:279797001 xref: UMLS:C0229827 {source="ncithesaurus:Sacral_Lymph_Node"} xref: Wikipedia:Sacral_lymph_nodes is_a: UBERON:0005179 ! pelvic region element is_a: UBERON:8470001 ! sublumbar lymph node intersection_of: UBERON:0000029 ! lymph node intersection_of: BFO:0000050 UBERON:0005473 ! part of sacral region relationship: BFO:0000050 UBERON:0005473 ! part of sacral region [Term] id: UBERON:0002529 name: limb segment def: "A major subdivision of a mature or developing limb, including both skeletal elements (or the mesenchyme that gives rise to the skeletal elements) and associated tissues, such as muscle, connective tissue, integument. Examples: autopod region, zeugopod region, stylopod region, metapodial region, arm region. Excludes the limb girdles." [https://orcid.org/0000-0002-6601-2165] synonym: "extremity part" RELATED [] synonym: "free limb segment" EXACT [FMA:241863] synonym: "limb region" RELATED [] synonym: "region of limb" RELATED [] synonym: "segment of limb" EXACT [] synonym: "subdivision of limb" EXACT [] xref: FMA:241863 xref: MA:0002889 xref: NCIT:C38630 xref: UMLS:C1268195 {source="ncithesaurus:Extremity_Part"} is_a: BFO:0000002 is_a: UBERON:0010538 ! paired limb/fin segment intersection_of: UBERON:0010758 ! subdivision of organism along appendicular axis intersection_of: BFO:0000050 UBERON:0002101 ! part of limb disjoint_from: UBERON:0010912 ! subdivision of skeleton relationship: BFO:0000050 UBERON:0002101 ! part of limb relationship: BFO:0000051 UBERON:0014892 ! has part skeletal muscle organ, vertebrate relationship: RO:0002488 UBERON:0000068 ! existence starts during embryo stage relationship: RO:0002492 UBERON:0000066 ! existence ends during fully formed stage property_value: IAO:0000116 "TODO - align this with the CARO2 class 'appendage segment'; note the FMA class does not appear to require repetition" xsd:string [Term] id: UBERON:0002530 name: gland def: "An organ that functions as a secretory or excretory organ." [MGI:csmith, MP:0002163] subset: efo_slim subset: pheno_slim subset: uberon_slim synonym: "Druese" RELATED [BTO:0000522] synonym: "glandula" RELATED OMO:0003011 [BTO:0000522, Wikipedia:Gland] synonym: "glandular organ" EXACT [http://orcid.org/0000-0002-6601-2165] xref: AAO:0000212 xref: AEO:0000096 xref: BTO:0000522 xref: EFO:0000797 xref: EHDAA2:0003096 xref: EHDAA:2161 xref: EMAPA:18425 xref: FBbt:00100317 {sssom:mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"} xref: FMA:7146 xref: FMA:86294 xref: galen:Gland xref: HAO:0000375 xref: MA:0003038 xref: MAT:0000021 xref: MIAA:0000021 xref: NCIT:C13319 xref: SCTID:134358001 xref: UMLS:C1285092 {source="ncithesaurus:Gland"} xref: Wikipedia:Gland xref: WikipediaCategory:Glands is_a: UBERON:0000062 ! organ relationship: RO:0002162 NCBITaxon:6072 ! in taxon Eumetazoa relationship: RO:0002215 GO:0046903 ! capable of secretion relationship: RO:0003000 UBERON:0000463 ! produces organism substance property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/a/a1/Gray1026.png" xsd:anyURI property_value: skos:prefLabel "gland" xsd:string [Term] id: UBERON:0002532 name: epiblast (generic) def: "In amniote animal embryology, the epiblast is a tissue type derived either from the inner cell mass in mammals or the blastodisc in birds and reptiles. It lies above the hypoblast. In mammalian embryogenesis, the columnar cells of the epiblast are adjacent to the trophoblast, while the cuboidal cells of the hypoblast are closer to the blastocoele. The epiblast, whilst referred to as the primary ectoderm, differentiates to form all three layers of the trilaminar germ disc in a process called gastrulation[WP]. The outer of the two layers of the blastoderm that form during gastrulation, corresponding to primitive ectoderm during gastrulation and to the definitive ectoderm after gastrulation[ZFA]." [Wikipedia:Epiblast, ZFIN:curator] subset: early_development subset: grouping_class subset: uberon_slim subset: vertebrate_core synonym: "blastocyst" RELATED [] synonym: "ectoblast" RELATED [MP:0003886] synonym: "epiblast" EXACT [VHOG:0000243] synonym: "epiblastus" RELATED OMO:0003011 [Wikipedia:Epiblast] synonym: "primitive ectoderm" RELATED [VHOG:0000243] xref: BTO:0004593 xref: FMA:296704 xref: MAT:0000067 xref: MIAA:0000067 xref: VHOG:0000243 xref: Wikipedia:Epiblast is_a: UBERON:0002050 ! embryonic structure relationship: BFO:0000051 CL:0000352 ! has part epiblast cell property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/e/e3/Gray21.png" xsd:anyURI property_value: IAO:0000116 "MP says - tissue that gives rise to the ectoderm, endoderm and mesoderm of the embryo proper. In HOG, epiblast is part of primitive streak/blastpore, which is inconsistent with the MP definition of primitive streak as a ridge of the epiblast. Note that these terms, epiblast and hypoblast, are also used to describe layers of the avian embryonic blastoderm, but the layers so-named seem to be altogether different in these two kinds of vertebrate embryos(CVS). Consider obsoleting this as a grouping class" xsd:string property_value: skos:prefLabel "epiblast (generic)" xsd:string [Term] id: UBERON:0002533 name: post-anal tail bud def: "The rapidly proliferating mass of cells at the caudal extremity of the embryo; remnant of the primitive node." [BTO:0001445] subset: efo_slim subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "end bud" RELATED [BTO:0001445] synonym: "tail bud" EXACT [ZFA:0000077] synonym: "tail bud mesenchyme" RELATED [ZFA:0000077] synonym: "tailbud" EXACT [] xref: AAO:0011104 xref: BTO:0001445 xref: EFO:0002748 xref: EHDAA2:0001976 xref: EHDAA:1595 xref: EMAPA:16580 xref: MAT:0000070 xref: MIAA:0000070 xref: TAO:0000077 xref: VHOG:0000201 xref: XAO:0000107 xref: ZFA:0000077 is_a: UBERON:0002050 ! embryonic structure relationship: RO:0002162 NCBITaxon:7742 ! in taxon Vertebrata property_value: IAO:0000116 "See notes from https://github.com/obophenotype/uberon/wiki/The-neural-crest" xsd:string property_value: skos:prefLabel "post-anal tail bud" xsd:string [Term] id: UBERON:0002536 name: arthropod sensillum def: "Sense organ embedded in the integument and consisting of one or a cluster of sensory neurons and associated sensory structures, support cells and glial cells forming a single organised unit with a largely bona-fide boundary.[FBbt]." [FBbt:00007152, Wikipedia:Sensillum] subset: efo_slim subset: uberon_slim synonym: "sensillum" EXACT [FBbt:00007152, HAO:0000933] xref: BTO:0001237 xref: EFO:0000939 xref: FBbt:00007152 {sssom:mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"} xref: HAO:0000933 xref: MAT:0000163 xref: MIAA:0000163 xref: TGMA:0000540 xref: Wikipedia:Sensillum is_a: UBERON:0000020 ! sense organ relationship: BFO:0000050 UBERON:0001016 ! part of nervous system relationship: RO:0002162 NCBITaxon:6656 ! in taxon Arthropoda property_value: IAO:0000116 "this term should be ceded to the arthropod anatomy ontology" xsd:string [Term] id: UBERON:0002537 name: hermaphrodite gonad def: "A gonad with both testicular and ovarian aspects[WP]." [Wikipedia:Ovotestis] subset: efo_slim synonym: "glandula hermaphroditica" NARROW SENSU [Wikipedia:Ovotestis#In_gastropods] synonym: "hermaphrodite genitalia" EXACT [GO:0040035] synonym: "hermaphrodite gland" NARROW SENSU [Wikipedia:Ovotestis#In_gastropods] synonym: "ovotestis" RELATED [BTO:0000981] xref: BTO:0000981 xref: EFO:0000971 xref: MAT:0000165 xref: MIAA:0000165 xref: WBbt:0005178 xref: Wikipedia:Ovotestis is_a: UBERON:0000991 ! gonad intersection_of: UBERON:0000991 ! gonad intersection_of: RO:0002215 GO:0007283 ! capable of spermatogenesis intersection_of: RO:0002215 GO:0048477 ! capable of oogenesis relationship: BFO:0000050 UBERON:0007197 ! part of hermaphroditic organism relationship: RO:0002215 GO:0007283 ! capable of spermatogenesis relationship: RO:0002215 GO:0048477 ! capable of oogenesis [Term] id: UBERON:0002539 name: pharyngeal arch def: "One of a series of paired bulges that develop along the lateral walls of the foregut. The pharyngeal arches have developmental contributions from endoderm, mesoderm, and neural crest cells and are separated by anterior lateral endoderm out-pockets known as pharyngeal pouches." [http://orcid.org/0000-0002-6601-2165, PMID:16313389, ZFA:yb] subset: efo_slim subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "arcus pharyngei" RELATED OMO:0003011 [Wikipedia:Pharyngeal_arch] synonym: "branchial arch" NARROW [BTO:0001785, MP:0002884] synonym: "pharyngeal arches" EXACT OMO:0003004 [] synonym: "visceral arch" RELATED [] xref: AAO:0010359 xref: BTO:0001785 xref: EFO:0000959 xref: EHDAA:571 xref: EMAPA:16117 xref: FMA:293015 xref: GAID:1292 xref: MAT:0000242 xref: MESH:D001934 xref: MIAA:0000242 xref: NCIT:C34249 xref: SCTID:308766004 xref: TAO:0001306 xref: UMLS:C0080322 {source="ncithesaurus:Pharyngeal_Arch"} xref: VHOG:0000155 xref: Wikipedia:Pharyngeal_arch xref: XAO:0000096 xref: ZFA:0001306 is_a: UBERON:0000481 ! multi-tissue structure is_a: UBERON:0010188 {source="EHDAA2"} ! protuberance is_a: UBERON:0010314 ! structure with developmental contribution from neural crest relationship: BFO:0000050 UBERON:0008814 ! part of pharyngeal arch system relationship: BFO:0000050 UBERON:8450003 {source="PMID:16313389"} ! part of embryonic craniocervical region relationship: RO:0002256 UBERON:0007690 {source="PMID:16313389"} ! developmentally induced by early pharyngeal endoderm property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/8/8b/Gray41.png" xsd:anyURI property_value: skos:prefLabel "pharyngeal arch" xsd:string [Term] id: UBERON:0002540 name: lateral line system def: "A line of sensory organs and associated structures along the sides of fish and amphibia that detect vibrations and pressure changes." [http://orcid.org/0000-0002-6601-2165, ISBN:0471209627, ISBN:0815318960, Wikipedia:Lateral_line_system] subset: efo_slim subset: uberon_slim synonym: "lateral line organs" RELATED [VHOG:0001243] synonym: "lateral line stitches" RELATED [] synonym: "lateral-line organs" RELATED [] synonym: "ll" RELATED [] xref: AAO:0000269 xref: AAO:0000975 xref: EFO:0000941 xref: MAT:0000249 xref: MIAA:0000249 xref: TAO:0000034 xref: VHOG:0001243 xref: Wikipedia:Lateral_line_system xref: XAO:0000095 xref: ZFA:0000034 is_a: BFO:0000002 is_a: UBERON:0001032 ! sensory system relationship: BFO:0000051 UBERON:0010202 ! has part lateral line relationship: RO:0002131 UBERON:0000010 ! overlaps peripheral nervous system property_value: IAO:0000116 "we model this as being potentially inclusive of lateral line scales, and thus overlapping with the skeletal system. This is to accomodate TAO" xsd:string property_value: RO:0002161 NCBITaxon:32524 {source="http://tolweb.org/Amniota"} [Term] id: UBERON:0002544 name: digit def: "A subdivision of the autopod that has as part a series of phalanges together with associated vasculature, musculature, integument and nerves. It is continuous with the metapodial subdivision of the autopod, but does not include the metapodials. In species such as humans, fully formed digits are distinct, whereas in other species the digits may be connected by interdigital webbing, or may be completely unseparated (for example, in cetaceans)." [http://orcid.org/0000-0002-6601-2165, https://github.com/obophenotype/uberon/issues/420] subset: efo_slim subset: pheno_slim subset: uberon_slim synonym: "acropodial unit" EXACT [] synonym: "digit (phalangeal portion) plus soft tissue" EXACT COMPARATIVE_PREFERRED [http://orcid.org/0000-0002-6601-2165] synonym: "limb digit" EXACT [MA:0000690] xref: AAO:0011126 xref: EFO:0000881 xref: EMAPA:32725 xref: galen:Digit xref: MA:0000690 xref: MAT:0000285 xref: MIAA:0000285 xref: NCIT:C40186 xref: SCTID:361367007 xref: UMLS:C0582802 {source="ncithesaurus:Digit"} xref: VHOG:0000944 xref: Wikipedia:Digit_(anatomy) xref: XAO:0003032 is_a: BFO:0000002 is_a: UBERON:0005881 ! autopodial extension intersection_of: UBERON:0005881 ! autopodial extension intersection_of: BFO:0000050 UBERON:0012354 ! part of acropodium region relationship: BFO:0000050 UBERON:0012354 ! part of acropodium region relationship: BFO:0000050 UBERON:5002544 ! part of digit plus metapodial segment relationship: BFO:0000051 UBERON:0015023 ! has part phalanx endochondral element relationship: RO:0002433 UBERON:0002470 ! contributes to morphology of autopod region property_value: terms:contributor https://orcid.org/0000-0001-7972-3866 property_value: terms:contributor https://orcid.org/0000-0002-6601-2165 property_value: terms:contributor https://orcid.org/0000-0002-8688-6599 property_value: terms:contributor https://orcid.org/0000-0003-3162-7490 [Term] id: UBERON:0002546 name: cranial placode def: "Ectodermal placode that develops in the head into a part of the sensory nervous system. With a few exceptions (lens, adenohypophyseal), cranial placodes are neurogenic." [http://www.ncbi.nlm.nih.gov/books/NBK53175/, https://github.com/obophenotype/uberon/issues/135, https://github.com/seger/aao/issues/4, https://orcid.org/0000-0002-6601-2165, https://sourceforge.net/p/obo/xenopus-anatomy-xao-term-requests/11/] subset: efo_slim synonym: "cranial placodes" RELATED OMO:0003004 [XAO:0000305] synonym: "ectodermal cranial placode" EXACT [UBERON:cjm] synonym: "ectodermal placode" BROAD INCONSISTENT [FMA:293966, PMID:22512454] synonym: "placode" BROAD [Wikipedia:Placode] xref: AAO:0010466 xref: EFO:0001650 xref: MAT:0000369 xref: MIAA:0000369 xref: XAO:0000305 is_a: UBERON:0005085 {source="cjm"} ! ectodermal placode relationship: BFO:0000050 UBERON:0000033 ! part of head relationship: RO:0002162 NCBITaxon:7711 {source="PMID:11523831", source="PMID:22512454"} ! in taxon Chordata property_value: IAO:0000116 "Do not merge with neurogenic placode" xsd:string property_value: skos:prefLabel "cranial placode" xsd:string [Term] id: UBERON:0002548 name: larva def: "A distinct juvenile form many animals undergo before metamorphosis into adults. Animals with indirect development such as insects, amphibians, or cnidarians typically have a larval phase of their life cycle." [Wikipedia:Larva] subset: uberon_slim synonym: "ammocoete" NARROW [Wikipedia:Larva] synonym: "bipinnaria" NARROW [Wikipedia:Larva] synonym: "caterpillar" NARROW [Wikipedia:Larva] synonym: "glochidium" NARROW [Wikipedia:Larva] synonym: "grub" NARROW [Wikipedia:Larva] synonym: "larval organism" EXACT [TAO:0002048] synonym: "leptocephalus" NARROW [Wikipedia:Larva] synonym: "maggot" NARROW [Wikipedia:Larva] synonym: "naiad" NARROW [Wikipedia:Larva] synonym: "nymph" NARROW [Wikipedia:Larva] synonym: "planula" NARROW [Wikipedia:Larva] synonym: "tadpole" NARROW [Wikipedia:Larva] synonym: "trochophore" NARROW [Wikipedia:Larva] synonym: "veliger" NARROW [Wikipedia:Larva] synonym: "wriggler" NARROW [Wikipedia:Larva] synonym: "zoea" NARROW [Wikipedia:Larva] xref: AEO:0000126 xref: BTO:0000707 xref: FBbt:00001727 {sssom:mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"} xref: HAO:0000459 xref: TAO:0002048 xref: Wikipedia:Larva is_a: UBERON:0000468 ! multicellular organism intersection_of: UBERON:0000468 ! multicellular organism intersection_of: RO:0002491 UBERON:0000069 ! existence starts and ends during larval stage relationship: RO:0000086 PATO:0001185 ! has quality larval relationship: RO:0002491 UBERON:0000069 ! existence starts and ends during larval stage property_value: IAO:0000116 "TODO discriminate between stages and organisms" xsd:string [Term] id: UBERON:0002550 name: anterior hypothalamic region synonym: "AHR" BROAD OMO:0003000 [BIRNLEX:1005, NIFSTD:NeuroNames_abbrevSource] synonym: "anterior hypothalamic area" EXACT [DHBA:266441551] synonym: "chiasmal zone" EXACT [FMA:62027] synonym: "preoptic division" RELATED [NeuroNames:376] xref: BAMS:AHR xref: BIRNLEX:1005 xref: DHBA:266441551 xref: FMA:62027 xref: HBA:12902 xref: HBA:4570 xref: MESH:D007032 xref: neuronames:2381 xref: neuronames:376 {source="BIRNLEX:1005"} xref: UMLS:C0020653 {source="BIRNLEX:1005"} is_a: UBERON:0002616 ! regional part of brain disjoint_from: UBERON:0002770 {source="lexical"} ! posterior hypothalamic region relationship: BFO:0000050 UBERON:0001898 ! part of hypothalamus property_value: skos:prefLabel "anterior hypothalamic region" xsd:string [Term] id: UBERON:0002553 name: anatomical cavity def: "Anatomical space which contains portions of one or more body substances and is bounded by the internal surface of one maximally connected anatomical structure. Examples: cranial cavity, pharyngeal recess space, nasal cavity, tooth socket, cavity of serous sac, lumen of stomach, lumen of artery, fornix of vagina." [FMA:67552] subset: upper_level synonym: "cavity" BROAD [] xref: BIRNLEX:1011 xref: EMAPA:37442 {source="MA:th"} xref: FMA:67552 xref: galen:Cavity xref: MA:0002447 xref: NCIT:C34007 is_a: UBERON:0000464 ! anatomical space relationship: RO:0001015 UBERON:0000463 ! location of organism substance property_value: skos:prefLabel "anatomical cavity" xsd:string [Term] id: UBERON:0002555 name: intermediate hypothalamic region def: "The portion of the hypothalamus located generally internal to the region of the infundibulum." [http://medical-dictionary.thefreedictionary.com] comment: ) synonym: "area hypothalamica intermedia" EXACT OMO:0003011 [FMA:62028, FMA:TA] synonym: "IHR" BROAD OMO:0003000 [BIRNLEX:1015, NIFSTD:NeuroNames_abbrevSource] synonym: "intermediate hypothalamic area" EXACT [FMA:62028] synonym: "intermediate hypothalamus" RELATED [TAO:0006000] synonym: "medial hypothalamus" RELATED [MESH:A08.186.211.730.385.357.352] synonym: "middle hypothalamus" RELATED [MESH:A08.186.211.730.385.357.352] synonym: "regio hypothalamica intermedia" RELATED OMO:0003011 [NeuroNames:392] xref: BAMS:IHR xref: BIRNLEX:1015 xref: FMA:62028 xref: MESH:D007033 xref: neuronames:392 {source="BIRNLEX:1015"} xref: TAO:0006000 xref: UMLS:C0020669 {source="BIRNLEX:1015"} is_a: UBERON:0002616 ! regional part of brain relationship: BFO:0000050 UBERON:0001898 ! part of hypothalamus property_value: skos:prefLabel "intermediate hypothalamic region" xsd:string [Term] id: UBERON:0002558 name: organ cavity subset: upper_level synonym: "cavity of organ" EXACT [FMA:12237] xref: BIRNLEX:1019 xref: FMA:12237 xref: SCTID:362606005 is_a: UBERON:0002553 ! anatomical cavity property_value: skos:prefLabel "organ cavity" xsd:string [Term] id: UBERON:0002561 name: lumen of central nervous system def: "The cavity that is enclosed by the central nervous system. In vertebrates this is the cavity that includes as parts ventricular cavities and the central canal of the spinal cord that develops from the lumen of the neura tube." [https://orcid.org/0000-0002-6601-2165] synonym: "cavity of neuraxis" EXACT [FMA:75007] synonym: "cavity of ventricular system of neuraxis" EXACT [FMA:75007] synonym: "neuraxis cavity" EXACT [FMA:75007] synonym: "neuraxis lumen" EXACT [] xref: BIRNLEX:1029 xref: FMA:75007 is_a: UBERON:0002558 ! organ cavity intersection_of: UBERON:0002558 ! organ cavity intersection_of: RO:0002572 UBERON:0001017 ! luminal space of central nervous system relationship: RO:0002572 UBERON:0001017 ! luminal space of central nervous system property_value: RO:0002175 NCBITaxon:569425 {source="DOI:10.1186/s12983-014-0089-2"} property_value: skos:prefLabel "lumen of central nervous system" xsd:string [Term] id: UBERON:0002567 name: basal part of pons def: "Ventral subdivision of the pons which consists of the massive pontine pertuberance on pontine ventral surface." [FMA:72244] subset: pheno_slim synonym: "basal part of the pons" RELATED [NeuroNames:616] synonym: "basal portion of pons" EXACT [FMA:72244] synonym: "base of pons" EXACT [FMA:72244] synonym: "basilar part of pons" EXACT [FMA:72244] synonym: "basilar pons" RELATED [NeuroNames:616] synonym: "basis pontis" RELATED OMO:0003011 [NeuroNames:616] synonym: "pars anterior pontis" RELATED OMO:0003011 [NeuroNames:616] synonym: "pars basilaris pontis" EXACT OMO:0003011 [FMA:72244, FMA:TA] synonym: "pars ventralis pontis" RELATED OMO:0003011 [NeuroNames:616] synonym: "pons proper" EXACT [FMA:72244] synonym: "ventral pons" EXACT [] synonym: "ventral portion of pons" EXACT [FMA:72244] xref: BAMS:Bpons xref: BIRNLEX:1043 xref: DHBA:12405 xref: FMA:72244 xref: HBA:9132 xref: neuronames:616 {source="BIRNLEX:1043"} xref: SCTID:361541001 xref: UMLS:C0228427 {source="BIRNLEX:1043"} xref: Wikipedia:Basilar_part_of_pons is_a: UBERON:0002616 ! regional part of brain relationship: BFO:0000050 UBERON:0000988 ! part of pons relationship: BFO:0000051 UBERON:0002152 ! has part middle cerebellar peduncle property_value: skos:prefLabel "basal part of pons" xsd:string [Term] id: UBERON:0002596 name: ventral posterior nucleus of thalamus def: "Part of thalamus receiving primary somatic sensory information via the medial lemniscal pathway that projects to the primary somatosensory cortex (adapted from Paxinos, The Rat Nervous System, 2nd Ed, Academic Press, 1995)." [BIRNLEX:1116] subset: uberon_slim synonym: "nuclei ventrales posteriores" RELATED OMO:0003011 [NeuroNames:343] synonym: "nucleus ventrales posteriores" EXACT [BIRNLEX:1116] synonym: "nucleus ventralis posterior" EXACT [BIRNLEX:1116] synonym: "ventral posterior" RELATED [BAMS:VP] synonym: "ventral posterior complex of the thalamus" RELATED [ABA:VP, BAMS:VP] synonym: "ventral posterior nucleus" EXACT [FMA:62187] synonym: "ventral posterior thalamic nucleus" EXACT [FMA:62187] synonym: "ventrobasal complex" EXACT [FMA:62187] synonym: "ventrobasal nucleus" EXACT [FMA:62187] synonym: "ventroposterior inferior nucleus" RELATED [BTO:0004374] synonym: "ventroposterior nucleus" RELATED [BTO:0004373] synonym: "ventroposterior nucleus of thalamus" RELATED [BAMS:VP] synonym: "VP" BROAD OMO:0003000 [BIRNLEX:1116, NIFSTD:NeuroNames_abbrevSource] synonym: "VPN" RELATED [BTO:0004373] xref: BAMS:VP xref: BIRNLEX:1116 xref: BM:Die-Th-VPI xref: BTO:0004373 xref: BTO:0004374 xref: DHBA:10423 xref: EMAPA:35912 xref: FMA:62187 xref: MBA:709 xref: neuronames:343 {source="BIRNLEX:1116"} xref: SCTID:279147005 xref: UMLS:C0175276 {source="BIRNLEX:1116"} xref: Wikipedia:Ventral_posterior_nucleus is_a: UBERON:0015233 ! nucleus of dorsal thalamus relationship: BFO:0000050 UBERON:0002776 {source="FMA"} ! part of ventral nuclear group property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/1/1b/ThalamicNuclei.png" xsd:anyURI property_value: skos:prefLabel "ventral posterior nucleus of thalamus" xsd:string [Term] id: UBERON:0002600 name: limbic lobe def: "Part of cerebral hemisphere located on the medial surface, forming a ring around the brain stem." [BIRNLEX:1128] subset: human_reference_atlas subset: pheno_slim subset: uberon_slim synonym: "fornicate convolution" RELATED [NeuroNames:834] synonym: "fornicate gyrus" EXACT [FMA:72719] synonym: "fornicate lobe" RELATED [NeuroNames:834] synonym: "grande lobe limbique of Broca" EXACT [] synonym: "gyrus fornicatus" RELATED OMO:0003011 [NeuroNames:834] synonym: "limbic lobe (carpenter)" EXACT [] synonym: "lobus limbicus" RELATED OMO:0003011 [Wikipedia:Limbic_lobe] xref: BAMS:Limbic_lobe xref: BAMS:LL xref: BIRNLEX:1128 xref: CALOHA:TS-2061 xref: DHBA:12155 xref: FMA:72719 xref: HBA:4219 xref: neuronames:834 {source="BIRNLEX:1128"} xref: SCTID:279215006 xref: UMLS:C0458337 {source="BIRNLEX:1128"} xref: Wikipedia:Limbic_lobe is_a: UBERON:0016526 {source="FMA"} ! lobe of cerebral hemisphere property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/7/7e/Human_brain_inferior-medial_view_description.JPG" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "limbic lobe" xsd:string [Term] id: UBERON:0002610 name: cochlear nuclear complex def: "The cochlear nuclei consist of: (a) the dorsal cochlear nucleus, corresponding to the tuberculum acusticum on the dorso-lateral surface of the inferior peduncle; and (b) the ventral or accessory cochlear nucleus, placed between the two divisions of the nerve, on the ventral aspect of the inferior peduncle. [WP,unvetted]." [Wikipedia:Cochlear_nuclei] subset: uberon_slim synonym: "cochlear nuclei" EXACT [FMA:72240] synonym: "nuclei cochleares" RELATED OMO:0003011 [Wikipedia:Cochlear_nuclei] xref: BAMS:CN xref: BIRNLEX:1151 xref: BM:Me-Co xref: DHBA:12437 xref: EV:0100260 xref: FMA:72240 xref: HBA:9528 xref: MBA:607 xref: neuronames:720 {source="BIRNLEX:1151"} xref: UMLS:C0152411 {source="ncithesaurus:Cochlear_Nuclei", source="BIRNLEX:1151"} xref: Wikipedia:Cochlear_nuclei is_a: UBERON:0019263 ! gray matter of hindbrain relationship: BFO:0000050 UBERON:0001896 ! part of medulla oblongata property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/5/52/Gray691.png" xsd:anyURI property_value: skos:prefLabel "cochlear nuclear complex" xsd:string [Term] id: UBERON:0002615 name: ventral tegmental decussation synonym: "anterior tegmental decussation" EXACT [FMA:72452] synonym: "decussatio inferior (Forel)" RELATED OMO:0003011 [NeuroNames:524] synonym: "decussatio tegmentalis anterior" EXACT OMO:0003011 [FMA:72452, FMA:TA] synonym: "decussatio tegmenti ventralis" RELATED OMO:0003011 [NeuroNames:524] synonym: "decussatio ventralis tegmenti" RELATED OMO:0003011 [NeuroNames:524] synonym: "decussation of forel" EXACT [] synonym: "inferior decussation (Forel's decussation)" RELATED [NeuroNames:524] synonym: "ventral tegmental decussation (Forel)" RELATED [NeuroNames:524] synonym: "ventral tegmental decussation of forel" EXACT [] synonym: "VTGX" BROAD OMO:0003000 [BIRNLEX:1163, NIFSTD:NeuroNames_abbrevSource] xref: BAMS:vtd xref: BAMS:vtgx xref: BIRNLEX:1163 xref: DHBA:12366 xref: DMBA:17807 xref: FMA:72452 xref: MBA:397 xref: neuronames:524 {source="BIRNLEX:1163"} xref: SCTID:369249001 xref: UMLS:C0152371 {source="BIRNLEX:1163"} is_a: UBERON:0007418 ! neural decussation intersection_of: UBERON:0007418 ! neural decussation intersection_of: BFO:0000050 UBERON:0002691 ! part of ventral tegmental area relationship: BFO:0000050 UBERON:0002691 ! part of ventral tegmental area property_value: skos:prefLabel "ventral tegmental decussation" xsd:string [Term] id: UBERON:0002616 name: regional part of brain def: "Anatomical divisons of the brain according to one or more criteria, e.g. cytoarchitectural, gross anatomy. Parts may be contiguous in 3D or not, e.g., basal ganglia." [BIRNLEX:1167] subset: non_informative synonym: "anatomical structure of brain" EXACT [OBOL:automatic] synonym: "biological structure of brain" EXACT [OBOL:automatic] synonym: "brain anatomical structure" EXACT [OBOL:automatic] synonym: "brain biological structure" EXACT [OBOL:automatic] synonym: "brain part" EXACT [] synonym: "neuraxis segment" EXACT [FMA:55676] synonym: "neuroanatomical region" EXACT [] synonym: "segment of brain" EXACT [BIRNLEX:1167] xref: BIRNLEX:1167 xref: FMA:55676 xref: NCIT:C13031 xref: SCTID:384763002 xref: UMLS:C0445620 {source="ncithesaurus:Brain_Part"} is_a: BFO:0000002 is_a: UBERON:0000073 ! regional part of nervous system intersection_of: UBERON:0000481 ! multi-tissue structure intersection_of: BFO:0000050 UBERON:0000955 ! part of brain relationship: BFO:0000050 UBERON:0000955 ! part of brain relationship: RO:0002473 UBERON:0003714 ! composed primarily of neural tissue property_value: skos:prefLabel "regional part of brain" xsd:string [Term] id: UBERON:0002622 name: preoptic periventricular nucleus def: "The preoptic periventricular nucleus is located along the midline and is medial to the medial preoptic nucleus.[WP,unvetted]." [Wikipedia:Preoptic_area#Preoptic_periventricular_nucleus] synonym: "dorsal periventricular hypothalamic nucleus" RELATED [NeuroNames:379] synonym: "nucleus periventricularis hypothalami, pars dorsalis" RELATED OMO:0003011 [NeuroNames:379] synonym: "nucleus periventricularis praeopticus" RELATED OMO:0003011 [NeuroNames:379] synonym: "nucleus periventricularis preopticus" RELATED OMO:0003011 [NeuroNames:379] synonym: "nucleus preopticus periventricularis" EXACT OMO:0003011 [FMA:62324, FMA:TA] synonym: "periventricular hypothalamic nucleus, preoptic part" RELATED [BAMS:PVpo] synonym: "periventricular nucleus, anterior portion" RELATED [NeuroNames:379] synonym: "periventricular preoptic nucleus" EXACT [FMA:62324] synonym: "POP" BROAD OMO:0003000 [BIRNLEX:1201, NIFSTD:NeuroNames_abbrevSource] synonym: "preoptic periventricular hypothalamic nucleus" EXACT [FMA:62324] xref: BAMS:POP xref: BAMS:PVpo xref: BIRNLEX:1201 xref: FMA:62324 xref: HBA:4549 xref: MBA:133 xref: neuronames:379 {source="BIRNLEX:1201"} xref: SCTID:369127000 xref: UMLS:C0175314 {source="BIRNLEX:1201"} xref: UMLS:C1289554 {source="BIRNLEX:1201"} xref: Wikipedia:Preoptic_area#Preoptic_periventricular_nucleus is_a: UBERON:0007251 ! preoptic nucleus relationship: RO:0002131 UBERON:8440005 ! overlaps rostral periventricular region of the third ventricle property_value: skos:prefLabel "preoptic periventricular nucleus" xsd:string [Term] id: UBERON:0002625 name: median preoptic nucleus def: "The median preoptic nucleus is located along the midline in a position significantly dorsal to the other 3 preoptic nuclei, at least in the macaca fascicularis brain. It wraps around the top (dorsal), front, and bottom (ventral) surfaces of the anterior commissure. The median preoptic nucleus generates thirst. Drinking decreases noradrenaline release in the median preoptic nucleus." [Wikipedia:Preoptic_area#Median_preoptic_nucleus] subset: uberon_slim synonym: "median preoptic nucleus (Loo)" RELATED [NeuroNames:378] synonym: "MnPO" BROAD OMO:0003000 [BIRNLEX:1208, NIFSTD:NeuroNames_abbrevSource] synonym: "nucleus praeopticus medianus" RELATED OMO:0003011 [NeuroNames:378] synonym: "nucleus preopticus medianus" RELATED OMO:0003011 [NeuroNames:378] synonym: "periventricular nucleus, preventricular portion" RELATED [NeuroNames:378] xref: BAMS:MEPO xref: BAMS:MnPO xref: BIRNLEX:1208 xref: BM:MPO xref: DHBA:13063 xref: FMA:62323 xref: HBA:4548 xref: MBA:452 xref: neuronames:378 {source="BIRNLEX:1208"} xref: UMLS:C0259793 {source="BIRNLEX:1208"} xref: Wikipedia:Preoptic_area#Median_preoptic_nucleus is_a: UBERON:0007251 ! preoptic nucleus relationship: RO:0002131 UBERON:8440005 ! overlaps rostral periventricular region of the third ventricle relationship: RO:0002215 GO:0048243 {source="Wikipedia"} ! capable of norepinephrine secretion relationship: RO:0002215 GO:2000070 {source="Wikipedia"} ! capable of regulation of response to water deprivation property_value: skos:prefLabel "median preoptic nucleus" xsd:string [Term] id: UBERON:0002639 name: midbrain reticular formation def: "Part of the reticular formation located in the midbrain tegmentum." [BIRNLEX:1235] synonym: "formatio reticularis mesencephali" RELATED OMO:0003011 [NeuroNames:501] synonym: "formatio reticularis tegmentalis" RELATED OMO:0003011 [NeuroNames:501] synonym: "formatio reticularis tegmenti mesencephali" RELATED OMO:0003011 [NeuroNames:501] synonym: "MBRF" BROAD OMO:0003000 [BIRNLEX:1235, NIFSTD:NeuroNames_abbrevSource] synonym: "reticular formation of midbrain" EXACT [FMA:62406] synonym: "substantia reticularis mesencephali" RELATED OMO:0003011 [NeuroNames:501] synonym: "tegmental reticular formation" EXACT [FMA:62406] xref: BAMS:MBRF xref: BIRNLEX:1235 xref: BM:MB-MBRF xref: DHBA:12239 xref: EMAPA:35570 xref: FMA:62406 xref: HBA:9018 xref: neuronames:501 {source="BIRNLEX:1235"} xref: SCTID:369234009 xref: UMLS:C0228394 {source="BIRNLEX:1235"} is_a: UBERON:0007245 ! nuclear complex of neuraxis is_a: UBERON:0019267 ! gray matter of midbrain relationship: BFO:0000050 UBERON:0001943 ! part of midbrain tegmentum relationship: BFO:0000050 UBERON:0002275 ! part of reticular formation relationship: BFO:0000051 UBERON:0002142 ! has part pedunculopontine tegmental nucleus property_value: skos:prefLabel "midbrain reticular formation" xsd:string [Term] id: UBERON:0002663 name: septal nuclear complex def: "Collection of nerve cells in the medial forebrain lying generally in front of the anterior commissure (Maryann Martone)." [BIRNLEX:1313] subset: uberon_slim synonym: "nuclei septales" RELATED OMO:0003011 [Wikipedia:Septal_nuclei] synonym: "parolfactory nuclei" EXACT [FMA:61845] synonym: "septal nuclei" EXACT [FMA:61845] synonym: "septal nucleus" EXACT [MA:0002978] xref: BAMS:SptN xref: BIRNLEX:1313 xref: DHBA:10350 xref: EHDAA2:0004709 xref: EMAPA:35763 xref: FMA:61845 xref: GAID:637 xref: HBA:13002 xref: MA:0002978 xref: MESH:D012686 xref: neuronames:259 xref: UMLS:C0036687 {source="BIRNLEX:1313"} xref: Wikipedia:Septal_nuclei is_a: UBERON:0005401 ! cerebral hemisphere gray matter is_a: UBERON:0007245 ! nuclear complex of neuraxis intersection_of: UBERON:0007245 ! nuclear complex of neuraxis intersection_of: BFO:0000050 UBERON:0000446 ! part of septum of telencephalon relationship: BFO:0000050 UBERON:0000446 ! part of septum of telencephalon relationship: BFO:0000050 UBERON:0002743 {source="NIFSTD"} ! part of basal forebrain property_value: skos:prefLabel "septal nuclear complex" xsd:string [Term] id: UBERON:0002667 name: lateral septal nucleus def: "Regional part of the septal nuclei, lying dorsal and slightly lateral to the medial septal nucleus. The lateral septum receives the bulk of projections of areas projecting to the septal nuclei (Adapted from Brodal, 1981)." [BIRNLEX:1321] synonym: "lateral parolfactory nucleus" EXACT [FMA:61878] synonym: "lateral septal nucleus (cajal)" EXACT [BIRNLEX:1321] synonym: "lateral septum" EXACT [BIRNLEX:1321] synonym: "lateral septum nucleus" EXACT [BIRNLEX:1321] synonym: "nucleus lateralis septi" RELATED OMO:0003011 [NeuroNames:261] synonym: "nucleus septalis lateralis" RELATED OMO:0003011 [NeuroNames:261] synonym: "nucleus septi lateralis" RELATED OMO:0003011 [NeuroNames:261] xref: BAMS:LS xref: BAMS:SLN xref: BIRNLEX:1321 xref: BM:Tel-Spt-SLN xref: DHBA:10352 xref: EMAPA:35486 xref: FMA:61878 xref: HBA:4303 xref: MBA:242 xref: neuronames:261 {source="BIRNLEX:1321"} xref: UMLS:C0175232 {source="BIRNLEX:1321"} is_a: UBERON:0009663 ! telencephalic nucleus intersection_of: UBERON:0002308 ! nucleus of brain intersection_of: BFO:0000050 UBERON:0007628 ! part of lateral septal complex relationship: BFO:0000050 UBERON:0007628 ! part of lateral septal complex property_value: skos:prefLabel "lateral septal nucleus" xsd:string [Term] id: UBERON:0002668 name: oculomotor nerve root def: "Initial segment of the occulomotor nerve as it leaves the midbrain." [BIRNLEX:1335] synonym: "3nf" BROAD OMO:0003000 [BIRNLEX:1323, NIFSTD:NeuroNames_abbrevSource] synonym: "central part of oculomotor nerve" EXACT [FMA:72457] synonym: "fibrae nervi oculomotorii" RELATED OMO:0003011 [NeuroNames:529] synonym: "oculomotor nerve fibers" EXACT [FMA:72457] synonym: "oculomotor nerve tract" RELATED [] synonym: "root of oculomotor nerve" EXACT [FMA:72457] xref: BAMS:3nf xref: BIRNLEX:1323 xref: BIRNLEX:1335 xref: DHBA:12376 xref: DMBA:17736 xref: FMA:72457 xref: neuronames:529 {source="BIRNLEX:1323"} xref: UMLS:C0175408 {source="BIRNLEX:1323"} is_a: UBERON:0006843 ! root of cranial nerve intersection_of: UBERON:0006843 ! root of cranial nerve intersection_of: extends_fibers_into UBERON:0001643 ! oculomotor nerve relationship: BFO:0000050 UBERON:0001943 ! part of midbrain tegmentum relationship: extends_fibers_into UBERON:0001643 ! oculomotor nerve property_value: skos:prefLabel "oculomotor nerve root" xsd:string [Term] id: UBERON:0002673 name: vestibular nuclear complex def: "Nuclear complex containing the vestibular nuclei." [UBERON:cjm] subset: uberon_slim synonym: "nuclei vestibulares" RELATED OMO:0003011 [Wikipedia:Vestibular_nuclei] synonym: "nuclei vestibulares in medulla oblongata" EXACT OMO:0003011 [FMA:72239, FMA:TA] synonym: "vestibular nuclei" EXACT [FMA:72239] synonym: "vestibular nuclei in medulla oblongata" EXACT [FMA:72239] synonym: "vestibular nucleus" RELATED [GO:0021750] xref: BAMS:Ve xref: BAMS:VNC xref: BIRNLEX:1337 xref: BM:Me-VS xref: BTO:0004368 xref: CALOHA:TS-2078 xref: FMA:72239 xref: GAID:602 xref: HBA:9697 xref: MBA:701 xref: MESH:D014726 xref: neuronames:714 {source="BIRNLEX:1337"} xref: UMLS:C0042600 {source="BIRNLEX:1337"} xref: Wikipedia:Vestibular_nuclei is_a: UBERON:0007245 ! nuclear complex of neuraxis is_a: UBERON:0019263 ! gray matter of hindbrain relationship: BFO:0000050 UBERON:0001896 {source="ABA", source="FMA", source="NIF"} ! part of medulla oblongata relationship: BFO:0000050 UBERON:0004681 {source="Wikipedia:Vestibular_nuclei"} ! part of vestibular system property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/5/52/Gray691.png" xsd:anyURI property_value: IAO:0000116 "In TA they are grouped in both the pons and medulla; DHBA has 'vestibular nuclei of pons', with LVN and SVN underneath; WP+MA says the SVN is in the pons, and GO includes VNC development under pons development, but this is not supported by ABA. Todo - check with NIF." xsd:string property_value: skos:prefLabel "vestibular nuclear complex" xsd:string [Term] id: UBERON:0002689 name: supraoptic crest def: "One of the circumventricular organs of the brain. The OVLT is outside the blood brain barrier, and so neurons in this region can respond to factors that are present in the systemic circulation." [https://sourceforge.net/tracker/?func=detail&aid=3474225&group_id=76834&atid=1205376, Wikipedia:Organum_vasculosum_of_the_lamina_terminalis] synonym: "olfactory ventricle (olfactory part of lateral ventricle)" RELATED [BAMS:OV] synonym: "organum vasculosum" RELATED [NeuroNames:383] synonym: "organum vasculosum lamina terminalis" EXACT OMO:0003011 [NLXANAT:100313] synonym: "organum vasculosum laminae terminalis" EXACT OMO:0003011 [FMA:62315, FMA:TA] synonym: "organum vasculosum of lamina terminalis" RELATED OMO:0003011 [NeuroNames:383] synonym: "OVLT" EXACT OMO:0003000 [BIRNLEX:1400] synonym: "prechiasmatic gland" EXACT [BIRNLEX:1400] synonym: "SoC" BROAD OMO:0003000 [BIRNLEX:1400, NIFSTD:NeuroNames_abbrevSource] synonym: "vascular organ of lamina terminalis" EXACT [FMA:62315] synonym: "vascular organ of the lamina terminalis" RELATED [NeuroNames:383] xref: BAMS:OV xref: BAMS:SoC xref: BAMS:VOLT xref: BIRNLEX:1400 xref: DHBA:12106 xref: DMBA:15582 xref: EMAPA:37742 {source="MA:th"} xref: FMA:62315 xref: MA:0003018 xref: MBA:763 xref: MESH:D066278 {sssom:mapping_justification="https://w3id.org/semapv/vocab/LexicalMatching"} xref: neuronames:383 {source="BIRNLEX:1400"} xref: NLXANAT:100313 xref: UMLS:C0175316 {source="BIRNLEX:1400"} xref: Wikipedia:Organum_vasculosum_of_the_lamina_terminalis is_a: UBERON:0010135 {source="MA"} ! sensory circumventricular organ relationship: BFO:0000050 UBERON:0002550 {source="FMA"} ! part of anterior hypothalamic region relationship: BSPO:0000108 UBERON:0000201 {source="Wikipedia"} ! endothelial blood brain barrier property_value: skos:prefLabel "supraoptic crest" xsd:string [Term] id: UBERON:0002690 name: anteroventral periventricular nucleus synonym: "anterior ventral periventricular nucleus of hypothalamus" RELATED [BAMS:AVPe] synonym: "anteroventral periventricular nucleus of the hypothalamus" RELATED [BAMS:AVPV] synonym: "AVPe" BROAD OMO:0003000 [BIRNLEX:1401, NIFSTD:NeuroNames_abbrevSource] synonym: "nucleus periventricularis anteroventralis" RELATED OMO:0003011 [NeuroNames:382] synonym: "ventral periventricular hypothalamic nucleus" RELATED [NeuroNames:382] xref: BAMS:AVPe xref: BAMS:AVPV xref: BIRNLEX:1401 xref: DHBA:13061 xref: FMA:62314 xref: HBA:4550 xref: MBA:272 xref: neuronames:382 {source="BIRNLEX:1401"} xref: UMLS:C0262200 {source="BIRNLEX:1401"} is_a: UBERON:0006568 ! hypothalamic nucleus relationship: BFO:0000050 UBERON:0002550 {source="FMA"} ! part of anterior hypothalamic region relationship: RO:0002131 UBERON:8440005 ! overlaps rostral periventricular region of the third ventricle property_value: skos:prefLabel "anteroventral periventricular nucleus" xsd:string [Term] id: UBERON:0002691 name: ventral tegmental area def: "Unpaired midbrain region situated in the ventromedial portion of the reticular formation. The VTA is medial to the substantia nigra and ventral to the red nucleus, and extends caudally from the posterior hypothalamus in the diencephalon. The VTA contains dopamine neurons that project to various limbic and cortical areas and is a critical component of the brain's reward circuitry." [BIRNLEX:1415] subset: efo_slim subset: uberon_slim synonym: "a10a" EXACT OMO:0003011 [FMA:72438, FMA:TA] synonym: "area tegmentalis ventralis" RELATED OMO:0003011 [NeuroNames:521] synonym: "area tegmentalis ventralis (Tsai)" RELATED OMO:0003011 [NeuroNames:521] synonym: "tegmentum ventrale" RELATED [XAO:0004226] synonym: "ventral brain stem" RELATED [XAO:0004226] synonym: "ventral tegmental area (Tsai)" RELATED [NeuroNames:521] synonym: "ventral tegmental area of tsai" EXACT [FMA:72438] synonym: "ventral tegmental nucleus (Rioch)" RELATED [NeuroNames:521] synonym: "ventral tegmental nucleus (tsai)" EXACT [FMA:72438] synonym: "ventral tegmental nucleus of tsai" EXACT [FMA:72438] synonym: "ventromedial mesencephalic tegmentum" RELATED [BIRNLEX:1415] synonym: "VTA" BROAD OMO:0003000 [BIRNLEX:1415, NIFSTD:NeuroNames_abbrevSource] xref: BAMS:VTA xref: BIRNLEX:1415 xref: BM:MB-VTA xref: CALOHA:TS-2389 xref: DHBA:12261 xref: EFO:0001935 xref: EMAPA:35913 xref: FMA:72438 xref: GAID:587 xref: HBA:9066 xref: MBA:749 xref: MESH:D017557 xref: neuronames:521 {source="BIRNLEX:1415"} xref: UMLS:C0175405 {source="BIRNLEX:1415"} xref: Wikipedia:Ventral_tegmental_area xref: XAO:0004226 is_a: UBERON:0002616 ! regional part of brain relationship: BFO:0000050 UBERON:0001943 ! part of midbrain tegmentum property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/b/b6/Gray712.png" xsd:anyURI property_value: skos:prefLabel "ventral tegmental area" xsd:string [Term] id: UBERON:0002704 name: metathalamus def: "The metathalamus is a composite structure of the thalamus, consisting of the medial geniculate nucleus and the lateral geniculate nucleus. [WP,unvetted]." [Wikipedia:Metathalamus] subset: uberon_slim synonym: "corpora geniculata" RELATED OMO:0003011 [Wikipedia:Metathalamus] synonym: "geniculate group of dorsal thalamus" RELATED [BAMS:GENd] synonym: "geniculate group of the dorsal thalamus" EXACT [FMA:62023] synonym: "geniculate thalamic group" EXACT [MA:0000868] synonym: "geniculate thalamic nuclear group (metathalamus)" RELATED [BAMS:GENd] synonym: "MTh" BROAD OMO:0003000 [BIRNLEX:1461, NIFSTD:NeuroNames_abbrevSource] synonym: "nuclei metathalami" EXACT [BIRNLEX:1461] xref: BAMS:GENd xref: BAMS:Metathalamus xref: BAMS:MetThal xref: BAMS:MTh xref: BIRNLEX:1461 xref: EMAPA:35376 xref: EV:0100217 xref: FMA:62023 xref: MA:0000868 xref: MBA:1008 xref: MESH:D005829 {sssom:mapping_justification="https://w3id.org/semapv/vocab/LexicalMatching"} xref: neuronames:351 {source="BIRNLEX:1461"} xref: SCTID:361550004 xref: Wikipedia:Metathalamus is_a: UBERON:0015233 ! nucleus of dorsal thalamus property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/1/1b/ThalamicNuclei.png" xsd:anyURI property_value: skos:prefLabel "metathalamus" xsd:string [Term] id: UBERON:0002707 name: corticospinal tract def: "The corticospinal fibers that arise from the pyramidal cells within the cerebral cortex layer V of the precentral motor area, the premotor area and the postcentral gyrus, then descend into and through the medulla to form the lateral corticospinal tract and the anterior corticospinal tract." [ISBN:0-683-40008-8, MP:0002878] subset: human_reference_atlas subset: pheno_slim subset: uberon_slim synonym: "corticospinal fibers" EXACT [NeuroNames:1320] synonym: "fasciculus cerebro-spinalis" EXACT OMO:0003011 [NeuroNames:1320] synonym: "fasciculus pyramidalis" EXACT OMO:0003011 [NeuroNames:800] synonym: "fibrae corticospinales" EXACT OMO:0003011 [NeuroNames:1320] synonym: "pyramid (Willis)" EXACT [NeuroNames:800] synonym: "pyramidal tract" BROAD INCONSISTENT [BIRNLEX:1464, MP:0002878, neuronames:1320] synonym: "tractus cortico-spinalis" EXACT OMO:0003011 [NeuroNames:1320] synonym: "tractus corticospinalis" EXACT OMO:0003011 [NeuroNames:1320, Wikipedia:Corticospinal_tract] synonym: "tractus pyramidalis" EXACT OMO:0003011 [NeuroNames:800] xref: BAMS:P xref: BIRNLEX:1464 xref: BM:CST xref: BM:Me-PyT xref: DHBA:12776 xref: DMBA:17756 xref: EMAPA:36600 xref: FMA:72634 xref: GAID:702 xref: HBA:265505574 xref: MBA:190 xref: MBA:784 xref: MESH:D011712 xref: neuronames:1320 xref: neuronames:800 {source="BIRNLEX:1464"} xref: SCTID:362325000 xref: UMLS:C0034229 {source="BIRNLEX:1464"} xref: Wikipedia:Corticospinal_tract is_a: UBERON:0001018 ! axon tract relationship: BFO:0000050 UBERON:0025525 ! part of motor system relationship: BFO:0000050 UBERON:0036224 ! part of corticobulbar and corticospinal tracts property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/a/ac/Gray684.png" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "corticospinal tract" xsd:string [Term] id: UBERON:0002708 name: posterior periventricular nucleus synonym: "griseum periventriculare hypothalami" EXACT OMO:0003011 [NeuroNames:419] synonym: "nucleus periventricularis posterior" EXACT [BTO:0002479] synonym: "periventricular hypothalamic nucleus, posterior part" EXACT [NeuroNames:419] synonym: "periventricular nucleus, posterior subdivision" EXACT [FMA:62349] synonym: "posterior paraventricular nucleus" EXACT [BAMS:PVp] synonym: "posterior periventricular hypothalamic nucleus" EXACT [BIRNLEX:1466] synonym: "posterior periventricular nucleus" EXACT [FMA:62349] synonym: "posterior periventricular nucleus of hypothalamus" EXACT [FMA:62349] synonym: "posterior periventricular nucleus of the hypothalamus" EXACT [BAMS:PVp] synonym: "PPe" BROAD OMO:0003000 [BIRNLEX:1466, NIFSTD:NeuroNames_abbrevSource] xref: BAMS:PPe xref: BAMS:PVp xref: BIRNLEX:1466 xref: BTO:0002479 xref: DMBA:16441 xref: FMA:62349 xref: MBA:126 xref: neuronames:419 {source="BIRNLEX:1466"} xref: UMLS:C0262317 {source="BIRNLEX:1466"} is_a: UBERON:0006568 ! hypothalamic nucleus relationship: BFO:0000050 UBERON:0002770 {source="NIFSTD"} ! part of posterior hypothalamic region property_value: skos:prefLabel "posterior periventricular nucleus" xsd:string [Term] id: UBERON:0002709 name: posterior nuclear complex of thalamus def: "Part of thalamus comprising ill defined cellular groups in the caudal thalamus at the meso-diencephalic junction. It is not a homogeneous structure but consists of several distinct cellular groups, including the suprageniculate and limitans nuclei, the magnocellular division of the medial geniculate body, portions of the pulvinar nucleus and an area of mixed cell types intercalated between the ventroposterior nucleus and the nucleus lateral posterior (Brodal, Neurological Anatomy, 3rd ed., 1981, pg 97)." [BIRNLEX:1467] subset: vertebrate_core synonym: "caudal thalamic nucleus" EXACT [TAO:0000325] synonym: "nuclei posteriores thalami" EXACT [BIRNLEX:1467] synonym: "parieto-occipital" RELATED [BAMS:PO] synonym: "PNC" BROAD OMO:0003000 [BIRNLEX:1467, NIFSTD:NeuroNames_abbrevSource] synonym: "posterior complex of thalamus" EXACT [FMA:62024] synonym: "posterior complex of the thalamus" EXACT [BAMS:PO] synonym: "posterior nuclear complex" EXACT [FMA:62024] synonym: "posterior nuclear complex of thalamus" EXACT [FMA:62024] synonym: "posterior nuclear group of thalamus" EXACT [FMA:62024] synonym: "posterior nucleus of dorsal thalamus" EXACT [BAMS:Po] synonym: "posterior thalamic nuclear group" EXACT [FMA:62024] synonym: "posterior thalamic nucleus" EXACT [BTO:0002462] xref: BAMS:PNC xref: BAMS:PO xref: BAMS:Po xref: BIRNLEX:1467 xref: BTO:0002462 xref: DHBA:10428 xref: EMAPA:35697 xref: EMAPA:35698 xref: FMA:62024 xref: MBA:1020 xref: neuronames:360 {source="BIRNLEX:1467"} xref: SCTID:424395006 xref: UMLS:C0175298 {source="BIRNLEX:1467"} is_a: UBERON:0007245 ! nuclear complex of neuraxis is_a: UBERON:0019269 ! gray matter of diencephalon relationship: BFO:0000050 UBERON:0004703 {source="FMA"} ! part of dorsal thalamus property_value: IAO:0000116 "ZFA grouping dubious" xsd:string property_value: skos:prefLabel "posterior nuclear complex of thalamus" xsd:string [Term] id: UBERON:0002714 name: rubrospinal tract def: "White matter tract arising in red nucleus and projecting to spinal cord ventral horn." [BIRNLEX:1476] subset: uberon_slim synonym: "Monakow's tract" EXACT [FMA:72640] synonym: "rubrospinal tract (Monakow)" EXACT [BIRNLEX:1476] synonym: "tractus rubrospinalis" RELATED OMO:0003011 [Wikipedia:Rubrospinal_tract] xref: BAMS:rs xref: BAMS:rust xref: BIRNLEX:1476 xref: DHBA:12782 xref: DMBA:17792 xref: FMA:72640 xref: MBA:863 xref: neuronames:806 {source="BIRNLEX:1476"} xref: SCTID:369264001 xref: UMLS:C0152377 {source="BIRNLEX:1476"} xref: Wikipedia:Rubrospinal_tract is_a: UBERON:0007702 ! tract of brain relationship: BFO:0000050 UBERON:0014649 {source="FMA NIF combined"} ! part of white matter of medulla oblongata property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/b/b2/Spinal_cord_tracts_-_English.svg" xsd:anyURI property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/f/fe/Medulla_spinalis_-_tracts_-_English.svg" xsd:anyURI property_value: skos:prefLabel "rubrospinal tract" xsd:string [Term] id: UBERON:0002726 name: cervical spinal cord def: "A spinal cord segment that adjacent_to a cervical region." [OBOL:automatic] subset: human_reference_atlas synonym: "cervical segment of spinal cord" EXACT [FMA:71166] synonym: "cervical segments of spinal cord [1-8]" EXACT [FMA:71166] synonym: "cervical spinal cord" EXACT [FMA:71166] synonym: "pars cervicalis medullae spinalis" EXACT OMO:0003011 [FMA:71166, FMA:TA] synonym: "segmenta cervicalia medullae spinalis [1-8" EXACT OMO:0003011 [FMA:71166, FMA:TA] xref: BIRNLEX:1499 xref: FMA:71166 xref: MA:0003081 xref: MESH:D066193 {sssom:mapping_justification="https://w3id.org/semapv/vocab/LexicalMatching"} xref: NCIT:C12892 xref: neuronames:1654 xref: SCTID:180960003 xref: UMLS:C0581619 {source="BIRNLEX:1499", source="ncithesaurus:Cervical_Spinal_Cord"} xref: UMLS:C1278837 {source="BIRNLEX:1499"} is_a: UBERON:0005844 ! spinal cord segment intersection_of: UBERON:0005844 ! spinal cord segment intersection_of: RO:0002220 UBERON:0005434 ! adjacent to cervical region relationship: RO:0002162 NCBITaxon:8287 ! in taxon Sarcopterygii relationship: RO:0002220 UBERON:0005434 ! adjacent to cervical region property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "cervical spinal cord" xsd:string [Term] id: UBERON:0002731 name: vestibulocochlear nerve root def: "Either of the two roots that come of the vestibulocochlear nerve." [http://orcid.org/0000-0002-6601-2165] synonym: "central part of vestibulocochlear nerve" EXACT [FMA:72499] synonym: "fibrae nervi statoacustici" EXACT OMO:0003011 [FMA:72499, FMA:TA] synonym: "root of vestibulocochlear nerve" EXACT [DHBA:12868] synonym: "statoacoustic nerve fibers" EXACT [FMA:72499] synonym: "vestibulocochlear nerve fibers" EXACT [FMA:72499] synonym: "vestibulocochlear nerve roots" EXACT [FMA:72499] synonym: "vestibulocochlear nerve tract" EXACT [FMA:72499] xref: BAMS:8nf xref: BIRNLEX:1519 xref: BIRNLEX:1636 xref: DHBA:12868 xref: DMBA:17746 xref: FMA:72499 xref: neuronames:605 is_a: UBERON:0006843 ! root of cranial nerve intersection_of: UBERON:0002211 ! nerve root intersection_of: extends_fibers_into UBERON:0001648 ! vestibulocochlear nerve relationship: BFO:0000050 UBERON:0003023 {source="FMA"} ! part of pontine tegmentum relationship: extends_fibers_into UBERON:0001648 ! vestibulocochlear nerve property_value: skos:prefLabel "vestibulocochlear nerve root" xsd:string [Term] id: UBERON:0002736 name: lateral nuclear group of thalamus def: "The lateral nuclear group is a collection of nuclei on the lateral side of the thalamus. According to MeSH, it consists of the following: lateral dorsal nucleus lateral posterior nucleus pulvinar [WP,unvetted]." [Wikipedia:Lateral_nuclear_group] subset: uberon_slim synonym: "lateral group of nuclei" EXACT [HBA:DTL] synonym: "lateral group of the dorsal thalamus" EXACT [BIRNLEX:1537] synonym: "lateral nuclear group" EXACT [FMA:62174] synonym: "lateral nuclear group of dorsal thalamus" EXACT [] synonym: "lateral nuclear group of thalamus" EXACT [FMA:62174] synonym: "lateral nucleus of thalamus" EXACT [FMA:62174] synonym: "lateral thalamic group" EXACT [MA:0000862] synonym: "lateral thalamic nuclear group" RELATED [BAMS:LAT] synonym: "lateral thalamic nuclear region" RELATED [BAMS:LTh] synonym: "lateral thalamic nuclei" EXACT [FMA:62174] synonym: "lateral thalamic nucleus" EXACT [BIRNLEX:1537] synonym: "LNG" BROAD OMO:0003000 [BIRNLEX:1537, NIFSTD:NeuroNames_abbrevSource] synonym: "nuclei laterales thalami" EXACT [BIRNLEX:1537] synonym: "nucleus lateralis thalami" EXACT [BIRNLEX:1537] xref: BAMS:LAT xref: BAMS:LNG xref: BAMS:LTh xref: BIRNLEX:1537 xref: CALOHA:TS-2028 xref: EMAPA:35487 xref: EV:0100210 xref: FMA:62174 xref: GAID:661 xref: HBA:12923 xref: MA:0000862 xref: MBA:138 xref: MESH:D020647 xref: neuronames:325 {source="BIRNLEX:1537"} xref: SCTID:279126006 xref: Wikipedia:Lateral_nuclear_group is_a: UBERON:0015233 ! nucleus of dorsal thalamus property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/1/1b/ThalamicNuclei.png" xsd:anyURI property_value: skos:prefLabel "lateral nuclear group of thalamus" xsd:string [Term] id: UBERON:0002743 name: basal forebrain def: "A region of the brain consisting of ventral and rostral subcortical regions of the telencephalon, including among others, the basal ganglia, septal nuclei, amygdala, ventral pallidum, substantia innominata, and basal nucleus of Meynert." [BIRNLEX:1560] subset: human_reference_atlas subset: uberon_slim synonym: "basal forebrain area" RELATED [NeuroNames:1997] synonym: "pars basalis telencephali" RELATED OMO:0003011 [Wikipedia:Basal_forebrain] xref: BAMS:Basal_forebrain xref: BIRNLEX:1560 xref: BM:Tel-BF xref: BTO:0002444 xref: DHBA:10349 xref: EMAPA:35164 xref: FMA:77700 xref: HBA:4300 xref: neuronames:1997 {source="BIRNLEX:1560"} xref: PBA:128012976 xref: Wikipedia:Basal_forebrain is_a: UBERON:0002616 ! regional part of brain relationship: BFO:0000050 UBERON:0001890 {source="BTO"} ! part of forebrain property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/a/a4/Basal_Forebrain_Monakhos_2007.png" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "basal forebrain" xsd:string [Term] id: UBERON:0002749 name: regional part of cerebellar cortex def: "A regional part of brain that is part of a cerebellar cortex [Automatically generated definition]." [OBOL:automatic] subset: non_informative synonym: "cerebellar cortical segment" EXACT [FMA:76924] synonym: "segment of cerebellar cortex" EXACT [BIRNLEX:1571] xref: BIRNLEX:1571 xref: FMA:76924 is_a: UBERON:0002616 ! regional part of brain intersection_of: UBERON:0000481 ! multi-tissue structure intersection_of: BFO:0000050 UBERON:0002129 ! part of cerebellar cortex relationship: BFO:0000050 UBERON:0002129 ! part of cerebellar cortex property_value: skos:prefLabel "regional part of cerebellar cortex" xsd:string [Term] id: UBERON:0002770 name: posterior hypothalamic region def: "The part of the hypothalamus posterior to the middle region consisting of several nuclei including the medial mamillary nucleus, lateral mamillary nucleus, and posterior hypothalamic nucleus (posterior hypothalamic area). The posterior hypothalamic area is concerned with control of sympathetic responses and is sensitive to conditions of decreasing temperature and controls the mechanisms for the conservation and increased production of heat." [MESH:A08.186.211.730.385.357.362] synonym: "hypothalamus posterior" RELATED OMO:0003011 [NeuroNames:411] synonym: "mammillary level of hypothalamus" EXACT [FMA:62029] synonym: "mammillary region" EXACT [FMA:62029] synonym: "PHR" BROAD OMO:0003000 [BIRNLEX:1651, NIFSTD:NeuroNames_abbrevSource] synonym: "posterior hypothalamus" EXACT [FMA:62029] synonym: "regio hypothalamica posterior" RELATED OMO:0003011 [NeuroNames:411] xref: BAMS:PH xref: BAMS:PHR xref: BIRNLEX:1651 xref: FMA:62029 xref: GAID:651 xref: HBA:4665 xref: MESH:D007034 xref: neuronames:411 {source="BIRNLEX:1651"} xref: UMLS:C0020670 {source="BIRNLEX:1651"} xref: Wikipedia:Mammillary_process is_a: UBERON:0002616 ! regional part of brain relationship: BFO:0000050 UBERON:0001898 ! part of hypothalamus property_value: skos:prefLabel "posterior hypothalamic region" xsd:string [Term] id: UBERON:0002776 name: ventral nuclear group def: "Nuclei in the ventral part of the thalamus, involved in modulating activity of dorsal thalamic nuclei." [ISBN:0471888893] subset: uberon_slim synonym: "dorsal thalamus, ventral group" EXACT [http://orcid.org/0000-0002-6601-2165] synonym: "nuclei ventrales thalami" EXACT [BIRNLEX:1669] synonym: "ventral dorsal thalamic nuclear group" RELATED [BAMS:VENT] synonym: "ventral group of dorsal thalamus" EXACT [BIRNLEX:1669] synonym: "ventral group of the dorsal thalamus" RELATED [BAMS:VENT] synonym: "ventral nuclear group" EXACT [FMA:62022] synonym: "ventral nuclear group of thalamus" EXACT [FMA:62022] synonym: "ventral nuclear mass" EXACT [FMA:62022] synonym: "ventral nuclei of thalamus" EXACT [FMA:62022] synonym: "ventral thalamus nucleus" RELATED [ZFA:0005576] synonym: "ventral tier thalamic nuclei" EXACT [FMA:62022] synonym: "VNG" BROAD OMO:0003000 [BIRNLEX:1669, NIFSTD:NeuroNames_abbrevSource] xref: BAMS:VENT xref: BAMS:VNG xref: BIRNLEX:1669 xref: BTO:0002467 xref: DMBA:16423 xref: EV:0100206 xref: FMA:62022 xref: MBA:637 xref: MESH:D020651 {sssom:mapping_justification="https://w3id.org/semapv/vocab/LexicalMatching"} xref: neuronames:333 {source="BIRNLEX:1669"} xref: SCTID:279125005 xref: UMLS:C0228333 {source="BIRNLEX:1669"} xref: Wikipedia:Ventral_nuclear_group xref: ZFA:0005576 is_a: UBERON:0015233 ! nucleus of dorsal thalamus property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/1/1b/ThalamicNuclei.png" xsd:anyURI property_value: skos:prefLabel "ventral nuclear group" xsd:string [Term] id: UBERON:0002792 name: lumbar spinal cord subset: human_reference_atlas subset: uberon_slim synonym: "lumbar segment of spinal cord" EXACT [FMA:71168] synonym: "lumbar segments of spinal cord [1-5]" EXACT [FMA:71168] synonym: "lumbar spinal cord" EXACT [FMA:71168] synonym: "pars lumbalis medullae spinalis" EXACT OMO:0003011 [FMA:71168, FMA:TA] synonym: "segmenta lumbalia medullae spinalis [1-5]" EXACT OMO:0003011 [FMA:71168, FMA:TA] synonym: "spinal cord lumbar segment" EXACT [MA:0003083] xref: BIRNLEX:1704 xref: FMA:71168 xref: MA:0003083 xref: NCIT:C12895 xref: neuronames:1677 xref: SCTID:180962006 xref: UMLS:C0581620 {source="BIRNLEX:1704"} xref: UMLS:C0581621 {source="ncithesaurus:Lumbar_Spinal_Cord"} xref: UMLS:C1278838 {source="BIRNLEX:1704"} xref: Wikipedia:Lumbar_spinal_cord is_a: UBERON:0005844 ! spinal cord segment intersection_of: UBERON:0005844 ! spinal cord segment intersection_of: BFO:0000050 UBERON:0005462 ! part of lower back relationship: BFO:0000050 UBERON:0005462 ! part of lower back property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0002802 name: left parietal lobe def: "Parietal lobe of the left hemisphere of the brain." [BIRNLEX:1728] xref: BIRNLEX:1728 xref: FMA:72974 xref: SCTID:314147009 xref: UMLS:C1281960 {source="BIRNLEX:1728"} is_a: UBERON:0001872 ! parietal lobe intersection_of: UBERON:0001872 ! parietal lobe intersection_of: BFO:0000050 UBERON:0002812 ! part of left cerebral hemisphere relationship: BFO:0000050 UBERON:0002812 ! part of left cerebral hemisphere relationship: RO:0002220 UBERON:0002921 ! adjacent to longitudinal fissure property_value: skos:prefLabel "left parietal lobe" xsd:string [Term] id: UBERON:0002803 name: right parietal lobe def: "Parietal lobe of the right hemisphere of the brain." [BIRNLEX:1729] xref: BIRNLEX:1729 xref: FMA:72973 xref: SCTID:314146000 xref: UMLS:C1281959 {source="BIRNLEX:1729"} is_a: UBERON:0001872 ! parietal lobe intersection_of: UBERON:0001872 ! parietal lobe intersection_of: BFO:0000050 UBERON:0002813 ! part of right cerebral hemisphere relationship: BFO:0000050 UBERON:0002813 ! part of right cerebral hemisphere relationship: RO:0002220 UBERON:0002921 ! adjacent to longitudinal fissure property_value: skos:prefLabel "right parietal lobe" xsd:string [Term] id: UBERON:0002804 name: left limbic lobe def: "A limbic lobe that is part of a left cerebral hemisphere." [OBOL:automatic] xref: BIRNLEX:1780 xref: FMA:72981 is_a: UBERON:0002600 ! limbic lobe intersection_of: UBERON:0002600 ! limbic lobe intersection_of: BFO:0000050 UBERON:0002812 ! part of left cerebral hemisphere relationship: BFO:0000050 UBERON:0002812 ! part of left cerebral hemisphere property_value: skos:prefLabel "left limbic lobe" xsd:string [Term] id: UBERON:0002805 name: right limbic lobe def: "A limbic lobe that is part of a right cerebral hemisphere." [OBOL:automatic] xref: BIRNLEX:1781 xref: FMA:72980 is_a: UBERON:0002600 ! limbic lobe intersection_of: UBERON:0002600 ! limbic lobe intersection_of: BFO:0000050 UBERON:0002813 ! part of right cerebral hemisphere relationship: BFO:0000050 UBERON:0002813 ! part of right cerebral hemisphere property_value: skos:prefLabel "right limbic lobe" xsd:string [Term] id: UBERON:0002808 name: left temporal lobe def: "A temporal lobe that is part of a left cerebral hemisphere." [OBOL:automatic] xref: BIRNLEX:1784 xref: FMA:72972 xref: SCTID:314158000 xref: UMLS:C1281971 {source="BIRNLEX:1784"} is_a: UBERON:0001871 ! temporal lobe intersection_of: UBERON:0001871 ! temporal lobe intersection_of: BFO:0000050 UBERON:0002812 ! part of left cerebral hemisphere relationship: BFO:0000050 UBERON:0002812 ! part of left cerebral hemisphere property_value: skos:prefLabel "left temporal lobe" xsd:string [Term] id: UBERON:0002809 name: right temporal lobe def: "A temporal lobe that is part of a right cerebral hemisphere." [OBOL:automatic] xref: BIRNLEX:1785 xref: FMA:72971 xref: SCTID:314157005 xref: UMLS:C1281970 {source="BIRNLEX:1785"} is_a: UBERON:0001871 ! temporal lobe intersection_of: UBERON:0001871 ! temporal lobe intersection_of: BFO:0000050 UBERON:0002813 ! part of right cerebral hemisphere relationship: BFO:0000050 UBERON:0002813 ! part of right cerebral hemisphere property_value: skos:prefLabel "right temporal lobe" xsd:string [Term] id: UBERON:0002810 name: right frontal lobe def: "A frontal cortex that is part of a right cerebral hemisphere." [OBOL:automatic] xref: BIRNLEX:1786 xref: FMA:72969 xref: SCTID:314141005 xref: UMLS:C1281954 {source="BIRNLEX:1786"} is_a: UBERON:0001870 ! frontal cortex intersection_of: UBERON:0001870 ! frontal cortex intersection_of: BFO:0000050 UBERON:0002813 ! part of right cerebral hemisphere relationship: BFO:0000050 UBERON:0002813 ! part of right cerebral hemisphere relationship: RO:0002220 UBERON:0002921 ! adjacent to longitudinal fissure property_value: skos:prefLabel "right frontal lobe" xsd:string [Term] id: UBERON:0002811 name: left frontal lobe def: "A frontal cortex that is part of a left cerebral hemisphere." [OBOL:automatic] xref: BIRNLEX:1787 xref: FMA:72970 xref: SCTID:314142003 xref: UMLS:C1281955 {source="BIRNLEX:1787"} is_a: UBERON:0001870 ! frontal cortex intersection_of: UBERON:0001870 ! frontal cortex intersection_of: BFO:0000050 UBERON:0002812 ! part of left cerebral hemisphere relationship: BFO:0000050 UBERON:0002812 ! part of left cerebral hemisphere relationship: RO:0002220 UBERON:0002921 ! adjacent to longitudinal fissure property_value: skos:prefLabel "left frontal lobe" xsd:string [Term] id: UBERON:0002812 name: left cerebral hemisphere def: "A cerebral hemisphere that is in the left side of a brain." [OBOL:automatic] synonym: "left hemisphere" EXACT [BIRNLEX:1795] xref: BIRNLEX:1795 xref: FMA:61819 xref: NCIT:C32955 xref: SCTID:362323007 xref: UMLS:C0228176 {source="ncithesaurus:Left_Cerebral_Hemisphere"} is_a: UBERON:0001869 ! cerebral hemisphere intersection_of: UBERON:0001869 ! cerebral hemisphere intersection_of: BSPO:0000120 UBERON:0000955 ! brain relationship: BSPO:0000120 UBERON:0000955 ! brain property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/brain-female/v1.4/assets/3d-allen-f-brain.glb" xsd:anyURI property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/brain-male/v1.4/assets/3d-allen-m-brain.glb" xsd:anyURI property_value: skos:prefLabel "left cerebral hemisphere" xsd:string [Term] id: UBERON:0002813 name: right cerebral hemisphere def: "A cerebral hemisphere that is in the right side of a brain." [OBOL:automatic] synonym: "right hemisphere" EXACT [BIRNLEX:1797] xref: BIRNLEX:1797 xref: FMA:67292 xref: NCIT:C33472 xref: SCTID:362322002 xref: UMLS:C0228175 {source="ncithesaurus:Right_Cerebral_Hemisphere"} is_a: UBERON:0001869 ! cerebral hemisphere intersection_of: UBERON:0001869 ! cerebral hemisphere intersection_of: BSPO:0000121 UBERON:0000955 ! brain relationship: BSPO:0000121 UBERON:0000955 ! brain property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/brain-female/v1.4/assets/3d-allen-f-brain.glb" xsd:anyURI property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/brain-male/v1.4/assets/3d-allen-m-brain.glb" xsd:anyURI property_value: skos:prefLabel "right cerebral hemisphere" xsd:string [Term] id: UBERON:0002824 name: vestibular ganglion def: "The ganglion of the vestibular nerve. It contains the cell bodies of the bipolar primary afferent neurons whose peripheral processes form synaptic contact with hair cells of the vestibular sensory end organs[WP,unvetted]. Distributed to the maculae of the utricle and saccule and to the ampullary crests of the semicircular ducts. The vestibular fibers arise in bipolar cells in the vestibular ganglion in the internal acoustic meatus." [http://www.dartmouth.edu/~humananatomy/part_8/chapter_44.html, Wikipedia:Scarpa%27s_ganglion] subset: human_reference_atlas subset: pheno_slim subset: uberon_slim synonym: "nucleus nervi oculomotorii, pars medialis" RELATED OMO:0003011 [NeuroNames:495] synonym: "Scarpa's ganglion" EXACT [FMA:53435] synonym: "vestibular part of vestibulocochlear ganglion" EXACT [http://orcid.org/0000-0002-6601-2165] synonym: "vestibulocochlear ganglion vestibular component" RELATED [EMAPA:17573] synonym: "vestibulocochlear VIII ganglion vestibular component" EXACT [MA:0001086] xref: BAMS:GvVIII xref: BIRNLEX:2549 xref: EMAPA:17573 xref: FMA:53435 xref: MA:0001086 xref: NCIT:C33870 xref: neuronames:495 {source="BIRNLEX:2549"} xref: RETIRED_EHDAA2:0002199 xref: SCTID:244450009 xref: UMLS:C0036286 {source="BIRNLEX:2549", source="ncithesaurus:Vestibular_Ganglion"} xref: UMLS:C0446706 {source="BIRNLEX:2549"} xref: VHOG:0000682 xref: Wikipedia:Scarpa%27s_ganglion is_a: UBERON:0001714 ! cranial ganglion is_a: UBERON:0001800 {source="ncithesaurus"} ! sensory ganglion intersection_of: UBERON:0001714 ! cranial ganglion intersection_of: extends_fibers_into UBERON:0003723 ! vestibular nerve relationship: BFO:0000050 UBERON:0001862 ! part of vestibular labyrinth relationship: BFO:0000050 UBERON:0002827 ! part of vestibulocochlear ganglion relationship: BFO:0000050 UBERON:0004681 ! part of vestibular system relationship: extends_fibers_into UBERON:0003723 ! vestibular nerve property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "vestibular ganglion" xsd:string [Term] id: UBERON:0002827 name: vestibulocochlear ganglion def: "The group of neuron cell bodies associated with the eighth cranial nerve during embryogenesis; splits in later development to form the cochlear and vestibular ganglia." [MGI:smb, MP:0003703] subset: efo_slim subset: pheno_slim subset: vertebrate_core synonym: "acoustic ganglion" RELATED [VHOG:0000696] synonym: "acoustic ganglion VIII" EXACT [EMAPA:16982] synonym: "acoustico-vestibular VIII ganglion" EXACT [EHDAA2:0002196] synonym: "auditory ganglion" EXACT [ZFA:0000588] synonym: "auditory ganglion" RELATED [BIRNLEX:2564] synonym: "ganglion VIII" EXACT [] synonym: "gVIII" EXACT [ZFA:0000588] synonym: "nucleus nervi oculomotorii ventrolateralis" RELATED OMO:0003011 [NeuroNames:496] synonym: "nucleus nervi oculomotorii, pars ventralis" RELATED OMO:0003011 [NeuroNames:496] synonym: "SAG" BROAD [ZFA:0000588] synonym: "statoacoustic (VIII) ganglion" EXACT [ZFA:0000588] synonym: "statoacoustic ganglia" EXACT [ZFA:0000588] synonym: "statoacoustic ganglion" EXACT [XAO:0004142] synonym: "statoacoustic VIII ganglion" RELATED [VHOG:0000696] synonym: "vestibulocochlear ganglia" RELATED OMO:0003004 [XAO:0004142] synonym: "vestibulocochlear VIII ganglion" EXACT [MA:0001084] xref: BIRNLEX:2564 xref: EFO:0003543 xref: EHDAA2:0002196 xref: EHDAA:5569 xref: EHDAA:6653 xref: EMAPA:16982 xref: EMAPA:17571 xref: MA:0001084 xref: neuronames:496 {source="BIRNLEX:2564"} xref: TAO:0000588 xref: UMLS:C0037959 {source="BIRNLEX:2564"} xref: VHOG:0000696 xref: XAO:0004142 xref: ZFA:0000588 is_a: UBERON:0001714 {source="ZFA"} ! cranial ganglion is_a: UBERON:0010313 ! neural crest-derived structure relationship: BFO:0000050 UBERON:0002105 {source="ZFA"} ! part of vestibulo-auditory system relationship: RO:0002202 UBERON:0003249 {source="NCBIBook:NBK53175"} ! develops from epithelium of otic placode relationship: RO:0002202 UBERON:0012175 {source="EHDAA2"} ! develops from acoustico-facial VII-VIII ganglion complex property_value: IAO:0000116 "Consider follow MA naming scheme." xsd:string property_value: skos:prefLabel "vestibulocochlear ganglion" xsd:string [Term] id: UBERON:0002828 name: ventral cochlear nucleus def: "The ventral cochlear nucleus (or anterior, or accessory), placed between the two divisions of the cochlear nerve, is on the ventral aspect of the inferior peduncle. Composed of several regions of distinct cell types, this nucleus serves primarily as a relay station for ascending auditory information. Bushy cells in the anterior ventral cochlear nucleus (AVCN), which receive end bulbs of held from auditory nerve fibers, project to the superior olivary complex through the trapezoid body and intermediate acoustic stria. Other cell types project to the lateral lemniscus and the inferior colliculus directly. [WP,unvetted]." [Wikipedia:Ventral_cochlear_nucleus] subset: uberon_slim synonym: "accessory cochlear nucleus" RELATED [NeuroNames:722] synonym: "anterior cochlear nucleus" EXACT [FMA:54621] synonym: "c1281209" EXACT [BIRNLEX:2567] synonym: "nucleus acustici accessorici" RELATED OMO:0003011 [NeuroNames:722] synonym: "nucleus cochlearis anterior" RELATED OMO:0003011 [NeuroNames:722] synonym: "nucleus cochlearis ventralis" RELATED OMO:0003011 [NeuroNames:722] synonym: "VCo" BROAD OMO:0003000 [BIRNLEX:2567, NIFSTD:NeuroNames_abbrevSource] synonym: "ventral cochlear nuclei" RELATED [NeuroNames:722] synonym: "ventral cochlear nucleus" EXACT [FMA:54621] synonym: "ventral coclear nucleus" RELATED [BAMS:VCO] synonym: "ventral division of cochlear nucleus" RELATED [NeuroNames:722] xref: BAMS:VC xref: BAMS:VCO xref: BIRNLEX:2567 xref: BM:CV xref: DHBA:12439 xref: FMA:54621 xref: HBA:9531 xref: MBA:101 xref: neuronames:722 {source="BIRNLEX:2567"} xref: SCTID:280178008 xref: UMLS:C0175500 {source="BIRNLEX:2567"} xref: Wikipedia:Ventral_cochlear_nucleus is_a: UBERON:0001720 ! cochlear nucleus disjoint_from: UBERON:0002829 {source="lexical"} ! dorsal cochlear nucleus property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/b/bb/Gray760.png" xsd:anyURI property_value: skos:prefLabel "ventral cochlear nucleus" xsd:string [Term] id: UBERON:0002829 name: dorsal cochlear nucleus def: "The dorsal cochlear nucleus (DCN, also known as the 'tuberculum acousticum'), is a cortex-like structure on the dorso-lateral surface of the brainstem. Along with the ventral cochlear nucleus, it forms the cochlear nucleus, where all auditory nerve fibers from the cochlea form their first synapses. [WP,unvetted]." [Wikipedia:Dorsal_cochlear_nucleus] subset: uberon_slim synonym: "DCo" BROAD OMO:0003000 [BIRNLEX:2569, NIFSTD:NeuroNames_abbrevSource] synonym: "dorsal cochlear nucleus" EXACT [FMA:54624] synonym: "dorsal coclear nucleus" RELATED [BAMS:DCO] synonym: "dorsal division of cochlear nucleus" EXACT [FMA:54624] synonym: "nucleus cochlearis dorsalis" RELATED OMO:0003011 [NeuroNames:721] synonym: "nucleus cochlearis posterior" RELATED OMO:0003011 [Wikipedia:Dorsal_cochlear_nucleus] synonym: "posterior cochlear nucleus" EXACT [FMA:54624] synonym: "tuberculum acousticum" EXACT [] xref: BAMS:DC xref: BAMS:DCO xref: BAMS:DCo xref: BIRNLEX:2569 xref: BM:Me-CD xref: DHBA:12438 xref: EMAPA:35289 xref: FMA:54624 xref: HBA:9530 xref: MBA:96 xref: NCIT:C32471 xref: neuronames:721 {source="BIRNLEX:2569"} xref: SCTID:280179000 xref: UMLS:C0175499 {source="BIRNLEX:2569", source="ncithesaurus:Dorsal_Cochlear_Nucleus"} xref: UMLS:C1281210 {source="BIRNLEX:2569"} xref: Wikipedia:Dorsal_cochlear_nucleus is_a: UBERON:0001720 ! cochlear nucleus property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/b/bb/Gray760.png" xsd:anyURI property_value: skos:prefLabel "dorsal cochlear nucleus" xsd:string [Term] id: UBERON:0002830 name: anteroventral cochlear nucleus synonym: "anterior part of anterior cochlear nucleus" EXACT [BIRNLEX:2572] synonym: "anterior part of the ventral cochlear nucleus" RELATED [NeuroNames:723] synonym: "anterior ventral cochlear nucleus" RELATED [NeuroNames:723] synonym: "anteroventral auditory nucleus" EXACT [FMA:72571] synonym: "AVCo" BROAD OMO:0003000 [BIRNLEX:2572, NIFSTD:NeuroNames_abbrevSource] synonym: "nucleus cochlearis anteroventralis" RELATED OMO:0003011 [NeuroNames:723] synonym: "nucleus magnocellularis" EXACT [BIRNLEX:2572] synonym: "ventral cochlear nucleus, anterior part" RELATED [NeuroNames:723] synonym: "ventral coclear nucleus anterior part" RELATED [NeuroNames:723] xref: BAMS:AVCo xref: BIRNLEX:2572 xref: DHBA:12440 xref: FMA:72571 xref: HBA:9532 xref: neuronames:723 {source="BIRNLEX:2572"} xref: UMLS:C0926557 {source="BIRNLEX:2572"} is_a: UBERON:0001720 ! cochlear nucleus disjoint_from: UBERON:0002831 {source="lexical"} ! posteroventral cochlear nucleus relationship: BFO:0000050 UBERON:0002828 {source="NIFSTD"} ! part of ventral cochlear nucleus property_value: skos:prefLabel "anteroventral cochlear nucleus" xsd:string [Term] id: UBERON:0002831 name: posteroventral cochlear nucleus synonym: "nucleus cochlearis posteroventralis" RELATED OMO:0003011 [NeuroNames:724] synonym: "posterior part of anterior cochlear nucleus" EXACT [BIRNLEX:2573] synonym: "posterior part of the ventral cochlear nucleus" RELATED [NeuroNames:724] synonym: "posterior ventral cochlear nucleus" RELATED [NeuroNames:724] synonym: "PVCo" BROAD OMO:0003000 [BIRNLEX:2573, NIFSTD:NeuroNames_abbrevSource] synonym: "ventral cochlear nucleus, posterior part" RELATED [NeuroNames:724] synonym: "ventral coclear nucleus posterior part" RELATED [NeuroNames:724] xref: BAMS:PVCo xref: BIRNLEX:2573 xref: DHBA:12441 xref: FMA:72572 xref: HBA:9533 xref: neuronames:724 {source="BIRNLEX:2573"} xref: UMLS:C0926558 {source="BIRNLEX:2573"} is_a: UBERON:0001720 ! cochlear nucleus relationship: BFO:0000050 UBERON:0002828 {source="NIFSTD"} ! part of ventral cochlear nucleus property_value: skos:prefLabel "posteroventral cochlear nucleus" xsd:string [Term] id: UBERON:0002834 name: cervical dorsal root ganglion subset: human_reference_atlas synonym: "cervical dorsal root ganglion" EXACT [FMA:6005] synonym: "cervical spinal ganglion" EXACT [FMA:6005] xref: BIRNLEX:2599 xref: FMA:6005 xref: SCTID:278325008 xref: UMLS:C0457466 {source="BIRNLEX:2599"} is_a: UBERON:0000044 ! dorsal root ganglion intersection_of: UBERON:0000044 ! dorsal root ganglion intersection_of: extends_fibers_into UBERON:0009632 ! root of cervical nerve relationship: extends_fibers_into UBERON:0009632 ! root of cervical nerve property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0002835 name: thoracic dorsal root ganglion def: "A dorsal root ganglion that is part of a thorax [Automatically generated definition]." [OBOL:automatic] subset: human_reference_atlas synonym: "dorsal root ganglion of thorax" EXACT [OBOL:automatic] synonym: "ganglion of dorsal root of thorax" EXACT [OBOL:automatic] synonym: "ganglion spinalis of thorax" EXACT [OBOL:automatic] synonym: "thoracic dorsal root ganglion" EXACT [FMA:6006] synonym: "thoracic spinal ganglion" EXACT [FMA:6006] synonym: "thorax dorsal root ganglion" EXACT [OBOL:automatic] synonym: "thorax ganglion of dorsal root" EXACT [OBOL:automatic] synonym: "thorax ganglion spinalis" EXACT [OBOL:automatic] xref: BIRNLEX:2600 xref: FMA:6006 xref: SCTID:278326009 xref: UMLS:C0457467 {source="BIRNLEX:2600"} is_a: UBERON:0000044 ! dorsal root ganglion intersection_of: UBERON:0000044 ! dorsal root ganglion intersection_of: extends_fibers_into UBERON:0009630 ! root of thoracic nerve relationship: extends_fibers_into UBERON:0009630 ! root of thoracic nerve property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0002836 name: lumbar dorsal root ganglion def: "The group of nerve cell bodies located on the dorsal spinal roots within the vertebral column at the level of the lumbar vertebrae." [MP:0006404] subset: human_reference_atlas subset: pheno_slim synonym: "lumbar dorsal root ganglion" EXACT [FMA:6007] synonym: "lumbar spinal ganglion" EXACT [FMA:6007] xref: BIRNLEX:2601 xref: FMA:6007 xref: SCTID:278327000 xref: UMLS:C0457468 {source="BIRNLEX:2601"} is_a: UBERON:0000044 ! dorsal root ganglion intersection_of: UBERON:0000044 ! dorsal root ganglion intersection_of: extends_fibers_into UBERON:0009631 ! root of lumbar spinal nerve relationship: extends_fibers_into UBERON:0009631 ! root of lumbar spinal nerve property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0002837 name: sacral dorsal root ganglion subset: human_reference_atlas synonym: "sacral dorsal root ganglion" EXACT [FMA:6008] synonym: "sacral spinal ganglion" EXACT [FMA:6008] xref: BIRNLEX:2602 xref: FMA:6008 xref: SCTID:278328005 xref: UMLS:C0457469 {source="BIRNLEX:2602"} is_a: UBERON:0000044 ! dorsal root ganglion intersection_of: UBERON:0000044 ! dorsal root ganglion intersection_of: extends_fibers_into UBERON:0009633 ! root of sacral nerve relationship: extends_fibers_into UBERON:0009633 ! root of sacral nerve property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0002871 name: hypoglossal nucleus def: "Nucleus forming a longitudinal cell column in the medulla, close beneath the floor of the 4th ventricle, containing motor neurons that innervate the muscles of the tongue (Brodal, Neurological Anatomy, 3rd ed., 1981, pg 453)." [BIRNLEX:2644] subset: pheno_slim subset: uberon_slim synonym: "hypoglossal nerve nucleus" EXACT [FMA:54505] synonym: "hypoglossal nucleus" EXACT [FMA:54505] synonym: "hypoglossal XII nucleus" EXACT [MA:0001039] synonym: "nucleus hypoglossalis" RELATED OMO:0003011 [NeuroNames:757] synonym: "nucleus nervi hypoglossi" EXACT OMO:0003011 [FMA:54505, FMA:TA] synonym: "nucleus nervi hypoglossi" RELATED OMO:0003011 [Wikipedia:Hypoglossal_nucleus] synonym: "nucleus of hypoglossal nerve" EXACT [FMA:54505] synonym: "twelfth cranial nerve nucleus" EXACT [FMA:54505] xref: BAMS:12 xref: BAMS:12N xref: BAMS:XII xref: BIRNLEX:2644 xref: BM:XII xref: DHBA:12545 xref: EHDAA2:0004635 xref: EMAPA:35416 xref: EV:0100286 xref: FMA:54505 xref: HBA:9557 xref: MA:0001039 xref: MBA:773 xref: NCIT:C12899 xref: ncithesaurus:Nucleus_of_the_Hypoglossal_Nerve xref: neuronames:757 {source="BIRNLEX:2644"} xref: SCTID:47361005 xref: UMLS:C0228802 {source="BIRNLEX:2644", source="ncithesaurus:Hypoglossal_Nucleus"} xref: VHOG:0001358 xref: Wikipedia:Hypoglossal_nucleus is_a: UBERON:0000126 ! cranial nerve nucleus is_a: UBERON:0007635 ! nucleus of medulla oblongata intersection_of: UBERON:0000126 ! cranial nerve nucleus intersection_of: extends_fibers_into UBERON:0001650 ! hypoglossal nerve relationship: extends_fibers_into UBERON:0001650 ! hypoglossal nerve property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/9/94/Gray694.png" xsd:anyURI property_value: skos:prefLabel "hypoglossal nucleus" xsd:string [Term] id: UBERON:0002886 name: lateral amygdaloid nucleus def: "The sensory interface of the amygdala where plasticity is mediated (Phelps & LeDoux, 2005, http://www.ncbi.nlm.nih.gov/pubmed/ 16242399)." [BIRNLEX:2687] subset: human_reference_atlas synonym: "lateral amygdala" RELATED [] synonym: "lateral amygdalar nucleus" RELATED [NeuroNames:245] synonym: "lateral nucleus of amygdala" EXACT [FMA:61866] synonym: "lateral nucleus of the amygdala" RELATED [NeuroNames:245] synonym: "lateral principal nucleus of amygdala" EXACT [FMA:61866] synonym: "medial principal nucleus" RELATED [BIRNLEX:2687] synonym: "nucleus amygdalae lateralis" RELATED [BTO:0002704] synonym: "nucleus amygdaloideus lateralis" RELATED OMO:0003011 [NeuroNames:245] synonym: "nucleus lateralis amygdalae" RELATED OMO:0003011 [NeuroNames:245] xref: BAMS:ALA xref: BAMS:LA xref: BAMS:La xref: BIRNLEX:2687 xref: BM:Tel-Am-ALA xref: BTO:0002704 xref: DHBA:10367 xref: DMBA:15944 xref: EMAPA:35476 xref: FMA:61866 xref: HBA:4378 xref: MA:0002926 xref: MBA:131 xref: neuronames:245 {source="BIRNLEX:2687"} xref: PBA:10116 xref: UMLS:C0175221 {source="BIRNLEX:2687"} is_a: UBERON:0009663 ! telencephalic nucleus disjoint_from: UBERON:0002892 {source="lexical"} ! medial amygdaloid nucleus relationship: BFO:0000050 UBERON:0006107 {source="NIFSTD"} ! part of basolateral amygdaloid nuclear complex property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "lateral amygdaloid nucleus" xsd:string [Term] id: UBERON:0002892 name: medial amygdaloid nucleus subset: human_reference_atlas synonym: "medial amygalar nucleus" EXACT [BIRNLEX:2701] synonym: "medial amygdala" RELATED [] synonym: "medial amygdalar nucleus" RELATED [NeuroNames:241] synonym: "medial amygdaloid nucleus principal part" RELATED [BAMS:MeA] synonym: "medial nucleus of amygdala" EXACT [FMA:74046] synonym: "medial nucleus of the amygdala" RELATED [BAMS:MEA] synonym: "nucleus amygdalae medialis" RELATED [BTO:0002702] synonym: "nucleus amygdaloideus medialis" RELATED OMO:0003011 [NeuroNames:241] synonym: "nucleus medialis amygdalae" RELATED OMO:0003011 [NeuroNames:241] xref: BAMS:Me xref: BAMS:MEA xref: BIRNLEX:2701 xref: BM:Tel-Am-AME xref: BTO:0002702 xref: EMAPA:35543 xref: EV:0100192 xref: FMA:74046 xref: MA:0002927 xref: MBA:403 xref: neuronames:241 {source="BIRNLEX:2701"} xref: UMLS:C0175217 {source="BIRNLEX:2701"} is_a: UBERON:0009663 ! telencephalic nucleus relationship: BFO:0000050 UBERON:0006108 {source="NIFSTD"} ! part of corticomedial nuclear complex property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "medial amygdaloid nucleus" xsd:string [Term] id: UBERON:0002893 name: nucleus of lateral olfactory tract comment: part of amygdala in FMA but this leads to inconsistency when combined with ABA partitions synonym: "lateral olfactory tract nucleus" EXACT [FMA:61865] synonym: "NLOT" EXACT OMO:0003000 [] synonym: "nucleus of the lateral olfactory tract" RELATED [NeuroNames:242] synonym: "nucleus of the lateral olfactory tract (ganser)" EXACT [BIRNLEX:2702] synonym: "nucleus of the olfactory tract" RELATED [BAMS:LOT] synonym: "nucleus of tractus olfactorius lateralis" RELATED OMO:0003011 [NeuroNames:242] synonym: "nucleus striae olfactoriae lateralis" RELATED OMO:0003011 [NeuroNames:242] xref: BAMS:LOT xref: BAMS:NLOT xref: BIRNLEX:2702 xref: BM:Tel-NLOT xref: DHBA:10309 xref: DMBA:15951 xref: EMAPA:35599 xref: FMA:61865 xref: HBA:4385 xref: MBA:619 xref: neuronames:242 {source="BIRNLEX:2702"} xref: UMLS:C0175218 {source="BIRNLEX:2702"} is_a: UBERON:0009663 ! telencephalic nucleus intersection_of: UBERON:0002308 ! nucleus of brain intersection_of: BFO:0000050 UBERON:0002894 ! part of olfactory cortex intersection_of: extends_fibers_into UBERON:0001888 ! lateral olfactory stria relationship: BFO:0000050 UBERON:0002894 ! part of olfactory cortex relationship: extends_fibers_into UBERON:0001888 ! lateral olfactory stria property_value: skos:prefLabel "nucleus of lateral olfactory tract" xsd:string [Term] id: UBERON:0002894 name: olfactory cortex def: "Aggregate brain region defined as those areas of cerebral cortex receiving direct synaptic input from the olfactory bulb (Price, 1973). It usually includes the piriform cortex and sometimes other areas." [BIRNLEX:2707] subset: human_reference_atlas subset: pheno_slim subset: uberon_slim synonym: "archaeocortex" RELATED [BTO:0001446] synonym: "archeocortex" RELATED [BTO:0001446] synonym: "olfactory areas" RELATED [BAMS:OLF] synonym: "olfactory lobe" RELATED [MA:0000193] xref: BAMS:OLF xref: BIRNLEX:2707 xref: BTO:0001446 xref: EHDAA2:0001289 xref: EHDAA:5482 xref: EMAPA:17779 xref: FMA:276600 xref: HBA:265504406 xref: MA:0000193 xref: MESH:D066194 xref: neuronames:2275 xref: UMLS:C0162434 {source="BIRNLEX:2707"} xref: VHOG:0000325 xref: Wikipedia:Olfactory_cortex is_a: UBERON:0002616 ! regional part of brain relationship: BFO:0000050 UBERON:0000956 {source="VHOG"} ! part of cerebral cortex relationship: BFO:0000050 UBERON:0005366 {source="MA"} ! part of olfactory lobe relationship: RO:0002433 UBERON:0005366 ! contributes to morphology of olfactory lobe property_value: IAO:0000116 "consider relationship: receives_input_from UBERON:0002264 olfactory bulb" xsd:string property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "olfactory cortex" xsd:string [Term] id: UBERON:0002916 name: central sulcus def: "The central sulcus is a fold in the cerebral cortex of brains in vertebrates. Also called the central fissure, it was originally called the fissure of Rolando or the Rolandic fissure, after Luigi Rolando. The central sulcus is a prominent landmark of the brain, separating the parietal lobe from the frontal lobe and the primary motor cortex from the primary somatosensory cortex. [WP,unvetted]." [Wikipedia:Central_sulcus] subset: uberon_slim synonym: "central cerebral sulcus" EXACT [FMA:83752] synonym: "central fissure" EXACT [FMA:83752] synonym: "central sulcus of Rolando" EXACT [] synonym: "CS" BROAD OMO:0003000 [BIRNLEX:4035, NIFSTD:NeuroNames_abbrevSource] synonym: "fissure of Rolando" EXACT [] synonym: "rolandic fissure" EXACT [BIRNLEX:4035] synonym: "sulcus centralis" EXACT [BIRNLEX:4035] synonym: "sulcus centralis (rolandi)" EXACT [BIRNLEX:4035] synonym: "sulcus centralis cerebri" EXACT OMO:0003011 [BIRNLEX:4035, Wikipedia:Central_sulcus] synonym: "sulcus of Rolando" EXACT [] xref: BAMS:cs xref: BIRNLEX:4035 xref: BM:Tel-Cx-CS xref: DHBA:10614 xref: FMA:83752 xref: HBA:9403 xref: NCIT:C32280 xref: neuronames:48 {source="BIRNLEX:4035"} xref: SCTID:279340001 xref: UMLS:C0228188 {source="ncithesaurus:Central_Sulcus_of_Rolando", source="BIRNLEX:4035"} xref: UMLS:C1281071 {source="BIRNLEX:4035"} xref: Wikipedia:Central_sulcus is_a: UBERON:0013118 ! sulcus of brain intersection_of: UBERON:0013118 ! sulcus of brain intersection_of: RO:0002176 UBERON:0001870 ! connects frontal cortex intersection_of: RO:0002176 UBERON:0001872 ! connects parietal lobe relationship: BFO:0000050 UBERON:0000956 {source="NIFSTD"} ! part of cerebral cortex relationship: RO:0002176 UBERON:0001870 ! connects frontal cortex relationship: RO:0002176 UBERON:0001872 ! connects parietal lobe property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/8/8e/Gray726_central_sulcus.svg" xsd:anyURI property_value: foaf:depiction "https://upload.wikimedia.org/wikipedia/commons/b/b6/Central_sulcus.png" xsd:anyURI property_value: skos:prefLabel "central sulcus" xsd:string [Term] id: UBERON:0002921 name: longitudinal fissure def: "The deep groove which separates the two hemispheres of the vertebrate brain. The falx cerebri, a dural brain covering, lies within the medial longitudinal fissure. [WP,unvetted]." [Wikipedia:Medial_longitudinal_fissure] subset: pheno_slim subset: uberon_slim synonym: "fissura interhemispherica" EXACT [BIRNLEX:4041] synonym: "fissura longitudinalis cerebrales" EXACT [BIRNLEX:4041] synonym: "fissura longitudinalis cerebri" EXACT [BIRNLEX:4041] synonym: "fissura longitudinalis magna" EXACT [BIRNLEX:4041] synonym: "hemispheric sulcus" EXACT [FMA:83727] synonym: "interhemispheric fissure" EXACT [FMA:83727] synonym: "LF" BROAD OMO:0003000 [BIRNLEX:4041, NIFSTD:NeuroNames_abbrevSource] synonym: "longitudinal cerebral fissure" EXACT [FMA:83727] synonym: "longitudinal fissure of hemisphere" EXACT [BIRNLEX:4041] synonym: "longitudinal fissure of the cerebrum" EXACT [BIRNLEX:4041] synonym: "longitudinal sulcus" EXACT [FMA:83727] synonym: "medial longitudinal fissure" EXACT [FMA:83727] synonym: "sagittal fissure" EXACT [FMA:83727] xref: BAMS:lf xref: BAMS:lfh xref: BIRNLEX:4041 xref: DHBA:10622 xref: FMA:83727 xref: HBA:9401 xref: NCIT:C33005 xref: neuronames:35 {source="BIRNLEX:4041"} xref: SCTID:369225004 xref: UMLS:C0228186 {source="BIRNLEX:4041", source="ncithesaurus:Longitudinal_Fissure"} xref: Wikipedia:Medial_longitudinal_fissure is_a: UBERON:0014466 {source="FMA"} ! subarachnoid fissure property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/9/92/Hemispheres.png" xsd:anyURI property_value: skos:prefLabel "longitudinal fissure" xsd:string [Term] id: UBERON:0002925 name: trigeminal nucleus def: "A nucleus of brain that is part of a trigeminal nuclear complex." [OBOL:automatic] subset: uberon_slim synonym: "nucleus mesencephalicus nervi trigemini" RELATED [BTO:0001074] synonym: "nucleus mesencephalicus trigeminalis" RELATED [BTO:0001074] synonym: "nucleus of trigeminal nuclear complex" EXACT [FMA:71247] synonym: "nucleus tractus mesencephali nervi trigeminalis" RELATED [BTO:0001074] synonym: "trigeminal nuclear complex nucleus" EXACT [FMA:71247] synonym: "trigeminal nucleus" EXACT [FMA:71248] synonym: "trigeminal V nucleus" EXACT [MA:0001028] xref: BM:V xref: BTO:0001074 xref: CALOHA:TS-2077 xref: EMAPA:35883 xref: EV:0100271 xref: FMA:71247 xref: GAID:604 xref: http://uri.neuinfo.org/nif/nifstd/nifext_11 xref: MA:0001028 xref: MESH:D014278 xref: NCIT:C12807 xref: SCTID:280164007 xref: UMLS:C0040999 {source="ncithesaurus:Trigeminal_Nucleus"} xref: VHOG:0001353 is_a: UBERON:0000126 ! cranial nerve nucleus intersection_of: UBERON:0002308 ! nucleus of brain intersection_of: BFO:0000050 UBERON:0007641 ! part of trigeminal nuclear complex relationship: BFO:0000050 UBERON:0007641 ! part of trigeminal nuclear complex relationship: extends_fibers_into UBERON:0001645 ! trigeminal nerve property_value: skos:prefLabel "trigeminal nucleus" xsd:string [Term] id: UBERON:0002926 name: gustatory epithelium def: "A sensory epithelium that is part of a gustatory system." [OBOL:automatic] xref: FMA:62412 xref: http://uri.neuinfo.org/nif/nifstd/nifext_12 is_a: UBERON:0006934 ! sensory epithelium intersection_of: UBERON:0006934 ! sensory epithelium intersection_of: BFO:0000050 UBERON:0001033 ! part of gustatory system relationship: BFO:0000050 UBERON:0000012 {source="NIFSTD"} ! part of somatic nervous system relationship: BFO:0000050 UBERON:0001033 ! part of gustatory system property_value: skos:prefLabel "gustatory epithelium" xsd:string [Term] id: UBERON:0002928 name: dentate gyrus polymorphic layer def: "A cellular layer of the dentate gyrus enclosed by the granule cell layer. A number of cell types are located in the polymorphic layer but the most prominent is the mossy cell." [http://orcid.org/0000-0002-6601-2165, PMCID:PMC2492885] synonym: "CA4" RELATED OMO:0003002 [PMID:17765709] synonym: "polymorph layer of the dentate gyrus" RELATED [BAMS:PoDG] xref: BAMS:po xref: BAMS:PoDG xref: BIRNLEX:4128 xref: EMAPA:35280 xref: MA:0002864 xref: MBA:10704 xref: neuronames:2123 xref: NLX:42439 is_a: UBERON:0002304 ! layer of dentate gyrus intersection_of: UBERON:0002304 ! layer of dentate gyrus intersection_of: BSPO:0001107 UBERON:0005381 ! dentate gyrus granule cell layer relationship: BSPO:0001107 UBERON:0005381 ! dentate gyrus granule cell layer relationship: RO:0002473 CL:0000540 ! composed primarily of neuron property_value: IAO:0000116 "TODO: add mossy cell" xsd:string property_value: skos:prefLabel "dentate gyrus polymorphic layer" xsd:string [Term] id: UBERON:0002945 name: ventral posteromedial nucleus of thalamus def: "The ventral posteromedial nucleus is a nucleus of the thalamus. [WP,unvetted]." [Wikipedia:Ventral_posteromedial_nucleus] subset: human_reference_atlas subset: uberon_slim synonym: "arcuate nucleus of thalamus" EXACT [FMA:62202] synonym: "arcuate nucleus of the thalamus" EXACT [BIRNLEX:743] synonym: "arcuate nucleus-3" EXACT [FMA:62202] synonym: "nucleus arcuatus thalami" EXACT [BIRNLEX:743] synonym: "nucleus semilunaris thalami" EXACT [BIRNLEX:743] synonym: "nucleus ventralis posterior medialis thalami" EXACT [BIRNLEX:743] synonym: "nucleus ventralis posteromedialis" EXACT [BIRNLEX:743] synonym: "nucleus ventralis posteromedialis thalami" EXACT [BIRNLEX:743] synonym: "nucleus ventralis posteromedialis thalami" RELATED OMO:0003011 [Wikipedia:Ventral_posteromedial_nucleus] synonym: "nucleus ventrocaudalis anterior internus (hassler)" EXACT [BIRNLEX:743] synonym: "posteromedial ventral nucleus" EXACT [FMA:62202] synonym: "posteromedial ventral nucleus of thalamus" EXACT [FMA:62202] synonym: "posteromedial ventral nucleus of the thalamus" EXACT [BIRNLEX:743] synonym: "semilunar nucleus" EXACT [FMA:62202] synonym: "thalamic gustatory nucleus" EXACT [FMA:62202] synonym: "ventral posterior medial nucleus" EXACT [FMA:62202] synonym: "ventral posterior medial nucleus of dorsal thalamus" RELATED [BAMS:VPM] synonym: "ventral posterior medial nucleus of thalamus" EXACT [BIRNLEX:743] synonym: "ventral posteromedial nucleus of thalamus" EXACT [FMA:62202] synonym: "ventral posteromedial nucleus of the thalamus" EXACT [BIRNLEX:743] synonym: "ventral posteromedial nucleus of the thalamus principal part" RELATED [BAMS:VPM] synonym: "ventral posteromedial nucleus of the thalamus, general" RELATED [NeuroNames:347] synonym: "ventral posteromedial nucleus of the thalamus, principal part" RELATED [BAMS:VPM] synonym: "ventral posteromedial thalamic nucleus" EXACT [BIRNLEX:743] synonym: "ventroposterior medial thalamic nucleus" RELATED [BAMS:VPM] synonym: "ventroposteromedial nucleus of the thalamus" EXACT [BIRNLEX:743] synonym: "VPM" BROAD OMO:0003000 [BIRNLEX:743, NIFSTD:NeuroNames_abbrevSource] xref: BAMS:Gus xref: BAMS:SL xref: BAMS:VPM xref: BIRNLEX:743 xref: BM:Die-Th-VPM xref: DHBA:10425 xref: DMBA:16429 xref: EMAPA:35911 xref: FMA:62202 xref: HBA:4424 xref: MBA:733 xref: NCIT:C33864 xref: neuronames:347 {source="BIRNLEX:743"} xref: SCTID:369172008 xref: UMLS:C0752056 {source="BIRNLEX:743"} xref: Wikipedia:Ventral_posteromedial_nucleus is_a: UBERON:0015233 ! nucleus of dorsal thalamus relationship: BFO:0000050 UBERON:0002596 {source="FMA"} ! part of ventral posterior nucleus of thalamus property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/1/1b/ThalamicNuclei.png" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "ventral posteromedial nucleus of thalamus" xsd:string [Term] id: UBERON:0002956 name: granular layer of cerebellar cortex def: "The granular layer is the innermost layer of the cerebellar cortex. This layer contains densely packed small neurons, mostly granule cells. Some Golgi cells are found at the outer border. Granule neurons send parallel fibers to the upper molecular layer, where they synapse with Purkinje cell dendrites. Mossy fibers from the pontine nuclei in the white matter synapse with granule cell axons, Golgi cell axons and unipolar brush interneuron axons at cerebellar glomeruli in the granule cell layer." [GO:0021681] subset: pheno_slim synonym: "cerebellar granular layer" EXACT [GO:0021681] synonym: "cerebellar granule cell layer" EXACT [] synonym: "cerebellar granule layer" EXACT [] synonym: "cerebellum granule cell layer" EXACT [MA:0000993] synonym: "cerebellum granule layer" EXACT [] synonym: "granular layer of cerebellum" RELATED [BTO:0004425] synonym: "granule cell layer of cerebellar cortex" EXACT [BIRNLEX:779] synonym: "stratum granulosum cerebelli" EXACT [BTO:0004425] synonym: "stratum granulosum corticis cerebelli" EXACT OMO:0003011 [FMA:83140, FMA:TA] xref: BIRNLEX:779 xref: BTO:0004425 xref: CALOHA:TS-1247 xref: EMAPA:35217 xref: FMA:83140 xref: MA:0000993 xref: MBA:1143 xref: NCIT:C49138 xref: neuronames:363 {source="BIRNLEX:779"} xref: UMLS:C1708253 {source="ncithesaurus:Granular_Layer_of_the_Cerebellum"} is_a: BFO:0000002 is_a: UBERON:0004130 ! cerebellar layer intersection_of: UBERON:0004130 ! cerebellar layer intersection_of: BSPO:0001101 UBERON:0002129 ! cerebellar cortex relationship: BFO:0000051 CL:0000119 ! has part cerebellar Golgi cell relationship: BFO:0000051 CL:0001031 ! has part cerebellar granule cell relationship: BFO:0000051 CL:4023161 ! has part unipolar brush cell relationship: BSPO:0001101 UBERON:0002129 ! cerebellar cortex property_value: skos:prefLabel "granular layer of cerebellar cortex" xsd:string [Term] id: UBERON:0002961 name: archicortex def: "A portion of the cerebral cortex that, with the paleocortex, develops in association with the olfactory system, and which is phylogenetically older than the neocortex and lacks its layered structure. The embryonic archicortex corresponds to the cortex of the dentate gyrus and hippocampus in mature mammals. Being part of the limbic system, it has functions related to emotions and formation of memory. Signals being sent from the limbic lobe to the hippocampal formations can go via the archicortex as an intermediate." [Wikipedia:Archicortex] subset: uberon_slim synonym: "archipallium" EXACT [FMA:62424] synonym: "hippocampal pallium" RELATED [] synonym: "hippocampus" RELATED [NeuroNames:170] synonym: "intralimbic gyrus" RELATED [NeuroNames:170] xref: BAMS:ACx xref: BIRNLEX:787 xref: DHBA:10293 xref: EHDAA2:0004496 xref: FMA:62424 xref: neuronames:170 xref: SCTID:423918008 xref: Wikipedia:Archicortex is_a: UBERON:0014734 {source="FMA"} ! allocortex relationship: BFO:0000050 UBERON:0002600 {source="FMA"} ! part of limbic lobe relationship: RO:0002216 GO:0007613 {source="Wikipedia"} ! capable of part of memory property_value: skos:prefLabel "archicortex" xsd:string [Term] id: UBERON:0002974 name: molecular layer of cerebellar cortex def: "The molecular layer is the outermost layer of the cerebellar cortex. It contains the parallel fibers of the granule cells, interneurons such as stellate and basket cells, and the dendrites of the underlying Purkinje cells." [GO:0021679] subset: pheno_slim synonym: "cerebellar molecular layer" EXACT [GO:0021679] synonym: "cerebellum molecular cell layer" EXACT [] synonym: "cerebellum molecular layer" EXACT [] synonym: "fasciculi thalami" RELATED OMO:0003011 [NeuroNames:366] synonym: "stratum moleculare corticis cerebelli" EXACT OMO:0003011 [FMA:83897, FMA:TA] synonym: "thalamic fiber tracts" RELATED [NeuroNames:366] xref: BAMS:thf xref: BIRNLEX:810 xref: CALOHA:TS-1248 xref: EMAPA:35221 xref: FMA:83897 xref: MA:0000996 xref: MBA:1144 xref: NCIT:C49139 xref: neuronames:366 {source="BIRNLEX:810"} xref: SCTID:369045002 xref: UMLS:C0228469 {source="BIRNLEX:810"} xref: UMLS:C1289474 {source="BIRNLEX:810"} xref: UMLS:C1709064 {source="ncithesaurus:Molecular_Layer_of_the_Cerebellum"} is_a: UBERON:0004130 ! cerebellar layer intersection_of: UBERON:0004130 ! cerebellar layer intersection_of: BSPO:0001100 UBERON:0002129 ! cerebellar cortex relationship: BFO:0000051 CL:0000118 ! has part basket cell relationship: BFO:0000051 CL:0000122 ! has part stellate neuron relationship: BSPO:0001100 UBERON:0002129 ! cerebellar cortex property_value: IAO:0000116 "revisit logical definition after using brain layer patterns" xsd:string property_value: skos:prefLabel "molecular layer of cerebellar cortex" xsd:string [Term] id: UBERON:0002979 name: Purkinje cell layer of cerebellar cortex def: "The Purkinje cell layer lies just underneath the molecular layer of the cerebellar cortex. It contains the neuronal cell bodies of the Purkinje cells that are arranged side by side in a single layer. Candelabrum interneurons are vertically oriented between the Purkinje cells. Purkinje neurons are inhibitory and provide the output of the cerebellar cortex through axons that project into the white matter. Extensive dendritic trees from the Purkinje cells extend upward in a single plane into the molecular layer where they synapse with parallel fibers of granule cells." [GO:0021680] subset: pheno_slim synonym: "cerebellar Purkinje cell layer" EXACT [FMA:83896, GO:0021694] synonym: "cerebellum Purkinje cell layer" EXACT [] synonym: "cerebellum Purkinje layer" EXACT [] synonym: "nuclei reticulares (thalami)" RELATED OMO:0003011 [NeuroNames:365] synonym: "nucleus reticularis" RELATED OMO:0003011 [NeuroNames:365] synonym: "nucleus reticulatus (thalami)" RELATED OMO:0003011 [NeuroNames:365] synonym: "nucleus thalamicus reticularis" RELATED OMO:0003011 [NeuroNames:365] synonym: "Purkinje cell layer" EXACT [FMA:83896] synonym: "reticular nucleus thalamus (Arnold)" RELATED [NeuroNames:365] synonym: "reticulatum thalami (Hassler)" RELATED OMO:0003011 [NeuroNames:365] xref: BIRNLEX:818 xref: BTO:0004909 xref: EMAPA:35223 xref: FMA:83896 xref: MA:0000997 xref: MBA:1145 xref: NCIT:C49140 xref: neuronames:365 {source="BIRNLEX:818"} xref: SCTID:369046001 xref: UMLS:C0228469 {source="BIRNLEX:818"} xref: UMLS:C1289475 {source="BIRNLEX:818"} xref: UMLS:C1709776 {source="ncithesaurus:Purkinje_Cell_Layer_of_the_Cerebellum"} is_a: BFO:0000002 is_a: UBERON:0004130 ! cerebellar layer intersection_of: UBERON:0004130 ! cerebellar layer intersection_of: BSPO:0001107 UBERON:0002974 ! molecular layer of cerebellar cortex intersection_of: BSPO:0015014 UBERON:0002956 ! granular layer of cerebellar cortex relationship: BSPO:0001107 UBERON:0002974 ! molecular layer of cerebellar cortex relationship: BSPO:0015014 UBERON:0002956 ! granular layer of cerebellar cortex relationship: RO:0002473 CL:0000121 ! composed primarily of Purkinje cell property_value: skos:prefLabel "Purkinje cell layer of cerebellar cortex" xsd:string [Term] id: UBERON:0003012 name: flocculonodular lobe def: "The flocculonodular lobe is a lobe of the cerebellum consisting of the nodule and the flocculus. It is closely associated with the vestibulocerebellum. [WP,unvetted]." [Wikipedia:Flocculonodular_lobe] subset: pheno_slim subset: uberon_slim synonym: "cerebellum flocculonodular lobe" EXACT [MA:0002965] synonym: "flocculonodular lobe" EXACT [FMA:72253] synonym: "flocculonodular lobe of cerebellum" EXACT [FMA:72253] synonym: "lobus flocculonodularis" EXACT OMO:0003011 [FMA:72253, FMA:TA] synonym: "posterior lobe-2 of cerebellum" EXACT [FMA:72253] xref: BAMS:FNL xref: BIRNLEX:904 xref: DHBA:12852 xref: EV:0100297 xref: FMA:72253 xref: HBA:12944 xref: MA:0002965 xref: neuronames:679 xref: SCTID:279361008 xref: Wikipedia:Flocculonodular_lobe is_a: UBERON:0005293 ! cerebellum lobe relationship: BFO:0000050 UBERON:0014642 {source="Wikipedia"} ! part of vestibulocerebellum relationship: RO:0002433 UBERON:0002129 ! contributes to morphology of cerebellar cortex property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/4/43/CerebellumDiv.png" xsd:anyURI property_value: skos:prefLabel "flocculonodular lobe" xsd:string [Term] id: UBERON:0003023 name: pontine tegmentum def: "Dorsal portion of the pons, containing cranial nervee nuclei, ascending and descending tracts and reticular nuclei. It is continuous with the reticular formation of the medulla (Carpenter, A Core Text of Neuroanatomy, 3rd ed, 1985, pg 133)." [BIRNLEX:923] subset: human_reference_atlas subset: uberon_slim synonym: "dorsal pons" EXACT [] synonym: "dorsal portion of pons" EXACT [FMA:71108] synonym: "pars dorsalis pontis" RELATED OMO:0003011 [NeuroNames:557] synonym: "pars posterior pontis" RELATED OMO:0003011 [NeuroNames:557] synonym: "tegmental portion of pons" EXACT [FMA:71108] synonym: "tegmentum of pons" EXACT [FMA:71108] synonym: "tegmentum pontis" EXACT OMO:0003011 [FMA:71108, FMA:TA] synonym: "tegmentum pontis" RELATED OMO:0003011 [Wikipedia:Pontine_tegmentum] xref: BAMS:PTg xref: BIRNLEX:923 xref: DHBA:12416 xref: FMA:71108 xref: HBA:9135 xref: neuronames:557 {source="BIRNLEX:923"} xref: SCTID:362401009 xref: UMLS:C0228426 {source="BIRNLEX:923"} xref: Wikipedia:Pontine_tegmentum is_a: BFO:0000002 is_a: UBERON:0000064 ! organ part relationship: BFO:0000050 UBERON:0000988 ! part of pons relationship: BFO:0000051 UBERON:0002047 ! has part pontine raphe nucleus relationship: BFO:0000051 UBERON:0002128 ! has part superior olivary complex relationship: BFO:0000051 UBERON:0002148 ! has part locus ceruleus relationship: BFO:0000051 UBERON:0002149 ! has part superior salivatory nucleus property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/brain-female/v1.4/assets/3d-allen-f-brain.glb" xsd:anyURI property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/brain-male/v1.4/assets/3d-allen-m-brain.glb" xsd:anyURI property_value: foaf:depiction "https://upload.wikimedia.org/wikipedia/commons/9/9c/Brainstem_Abducens.png" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "pontine tegmentum" xsd:string [Term] id: UBERON:0003030 name: posterior nucleus of thalamus subset: vertebrate_core synonym: "caudal thalamic nucleus" RELATED [TAO:0000325] synonym: "nucleus posterior thalami" EXACT [BIRNLEX:939] synonym: "nucleus thalami posterior" EXACT OMO:0003011 [FMA:62221, FMA:TA] synonym: "posterior nucleus of the thalamus" RELATED [NeuroNames:362] synonym: "PTh" BROAD OMO:0003000 [BIRNLEX:939, NIFSTD:NeuroNames_abbrevSource] xref: BAMS:PTh xref: BIRNLEX:939 xref: BM:Die-Th-Po xref: DHBA:10440 xref: FMA:62221 xref: HBA:4431 xref: NCIT:C33370 xref: neuronames:362 {source="BIRNLEX:939"} xref: SCTID:424901000 xref: TAO:0000325 xref: UMLS:C0262315 {source="BIRNLEX:939", source="ncithesaurus:Posterior_Nucleus_of_the_Thalamus"} xref: ZFA:0000325 is_a: UBERON:0015233 ! nucleus of dorsal thalamus intersection_of: UBERON:0002308 ! nucleus of brain intersection_of: BFO:0000050 UBERON:0002709 ! part of posterior nuclear complex of thalamus relationship: BFO:0000050 UBERON:0002709 {source="FMA", source="NIFSTD"} ! part of posterior nuclear complex of thalamus property_value: skos:prefLabel "posterior nucleus of thalamus" xsd:string [Term] id: UBERON:0003037 name: septum def: "A wall, dividing a cavity or structure into smaller ones[WP]." [Wikipedia:Septum] comment: general anatomical term in FMA subset: pheno_slim synonym: "septa" EXACT OMO:0003004 [] xref: AAO:0011127 xref: FMA:86461 xref: Wikipedia:Septum is_a: UBERON:0000061 ! anatomical structure relationship: RO:0001025 UBERON:0002553 ! located in anatomical cavity property_value: skos:prefLabel "septum" xsd:string [Term] id: UBERON:0003038 name: thoracic spinal cord def: "The thoracic nerves are the spinal nerves emerging from the thoracic vertebrae. [WP,unvetted]." [Wikipedia:Thoracic_spinal_cord] subset: human_reference_atlas subset: uberon_slim synonym: "pars thoracica medullae spinalis" EXACT OMO:0003011 [FMA:71167, FMA:TA] synonym: "segmenta thoracica medullae spinalis [1-12]" EXACT OMO:0003011 [FMA:71167, FMA:TA] synonym: "thoracic region of spinal cord" EXACT [FMA:71167] synonym: "thoracic segment of spinal cord" EXACT [FMA:71167] synonym: "thoracic segments of spinal cord [1-12]" EXACT [FMA:71167] synonym: "thoracic spinal cord" EXACT [FMA:71167] xref: BIRNLEX:966 xref: FMA:71167 xref: MA:0003082 xref: NCIT:C12894 xref: neuronames:1718 xref: SCTID:278750009 xref: UMLS:C0581620 {source="ncithesaurus:Thoracic_Spinal_Cord", source="BIRNLEX:966"} xref: Wikipedia:Thoracic_spinal_cord is_a: UBERON:0005844 ! spinal cord segment intersection_of: UBERON:0005844 ! spinal cord segment intersection_of: BFO:0000050 UBERON:0000915 ! part of thoracic segment of trunk relationship: BFO:0000050 UBERON:0008231 ! part of dorsal thoracic segment of trunk property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/6/68/Gray820.png" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "thoracic spinal cord" xsd:string [Term] id: UBERON:0003041 name: trigeminal nerve fibers def: "A nerve fiber that is part of a trigeminal nerve." [OBOL:automatic] synonym: "central part of trigeminal nerve" EXACT [FMA:72501] synonym: "fibrae nervi trigemini" RELATED OMO:0003011 [NeuroNames:607] synonym: "trigeminal nerve fibers" EXACT [FMA:72501] synonym: "trigeminal nerve tract" EXACT [FMA:72501] xref: BAMS:5nf xref: BIRNLEX:974 xref: FMA:72501 xref: neuronames:607 {source="BIRNLEX:974"} xref: UMLS:C0175452 {source="BIRNLEX:974"} is_a: UBERON:0006134 ! nerve fiber intersection_of: UBERON:0006134 ! nerve fiber intersection_of: BFO:0000050 UBERON:0001645 ! part of trigeminal nerve relationship: BFO:0000050 UBERON:0001645 ! part of trigeminal nerve property_value: skos:prefLabel "trigeminal nerve fibers" xsd:string [Term] id: UBERON:0003050 name: olfactory placode def: "A thick plate of cells derived from the neural ectoderm in the head region of the embryo that develops into the olfactory region of the nasal cavity." [Wikipedia:Nasal_placode, XAO:0000005] comment: Olfactory placodes are the only ectodermal placodes to produce glia, a cell type typically derived from neural crest // Note that NBK53171 classifies this as non-neurogenic subset: efo_slim subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "nasal I placode" RELATED [] synonym: "nasal placode" RELATED [] synonym: "olfactory placodes" EXACT OMO:0003004 [] synonym: "placoda nasalis" EXACT OMO:0003011 [] synonym: "placoda olfactoria" EXACT OMO:0003011 [] xref: AAO:0011076 xref: EFO:0003420 xref: EHDAA2:0001232 xref: EHDAA:1504 xref: EMAPA:16543 xref: FMA:293971 xref: TAO:0000048 xref: VHOG:0000186 xref: Wikipedia:Nasal_placode xref: XAO:0000005 xref: ZFA:0000048 is_a: UBERON:0009955 ! neurogenic placode relationship: BFO:0000050 UBERON:0000076 {source="EHDAA2"} ! part of external ectoderm relationship: RO:0002202 UBERON:0002346 ! develops from neurectoderm property_value: skos:prefLabel "olfactory placode" xsd:string [Term] id: UBERON:0003051 name: ear vesicle def: "An epithelial sac of invaginated ectoderm formed from the otic placode that gives rise to the structures of the inner ear[MP]." [MP:0009806, Wikipedia:Otic_vesicle] subset: pheno_slim subset: vertebrate_core synonym: "acoustic vesicle" RELATED [VHOG:0001148] synonym: "auditory vesicle" RELATED [BTO:0002661] synonym: "otic vesicle" EXACT [MP:0004311] synonym: "otocyst" RELATED [MP:0004311] synonym: "OV" RELATED [] xref: AAO:0011080 xref: BTO:0002661 xref: EHDAA2:0001342 xref: EMAPA:16669 xref: FMA:302920 xref: NCIT:C34240 xref: SCTID:308792006 xref: TAO:0000051 xref: UMLS:C1518678 {source="ncithesaurus:Otic_Vesicle"} xref: VHOG:0001148 xref: Wikipedia:Otic_vesicle xref: XAO:0000006 xref: ZFA:0000051 is_a: BFO:0000002 is_a: UBERON:0005291 ! embryonic tissue is_a: UBERON:0006598 ! presumptive structure is_a: UBERON:0007499 ! epithelial sac intersection_of: UBERON:0007499 ! epithelial sac intersection_of: BFO:0000050 UBERON:0000924 ! part of ectoderm intersection_of: RO:0002387 UBERON:0001846 ! has potential to develop into internal ear relationship: BFO:0000050 UBERON:0000924 ! part of ectoderm relationship: RO:0002202 UBERON:0006273 ! develops from otic pit relationship: RO:0002387 UBERON:0001846 ! has potential to develop into internal ear property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/2/2d/Gray40.png" xsd:anyURI property_value: skos:prefLabel "ear vesicle" xsd:string [Term] id: UBERON:0003052 name: midbrain-hindbrain boundary def: "The part of the brain that is the morphological boundary between the midbrain and hindbrain and that is the location of an organizing center which patterns the midbrain and hindbrain primordia of the neural plate." [GO:0021555] subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "isthmic organizer territory" RELATED [XAO:0000016] synonym: "isthmo-cerebellar region" RELATED [VHOG:0000649] synonym: "isthmus" RELATED [] synonym: "isthmus/MHB" RELATED [Geisha:syn, NCBITaxon:8782] synonym: "MHB" EXACT [] synonym: "mid-hindbrain boundary" EXACT [] synonym: "mid-hindbrain junction" EXACT [] synonym: "midbrain hindbrain boundary" EXACT [] xref: AAO:0011064 xref: DMBA:16810 xref: EHDAA2:0004395 xref: EHDAA:5789 xref: EMAPA:32857 xref: NCIT:C93172 xref: neuronames:2076 xref: TAO:0000042 xref: VHOG:0000649 xref: XAO:0000016 xref: ZFA:0000042 is_a: UBERON:0004121 ! ectoderm-derived structure is_a: UBERON:0007651 ! anatomical junction intersection_of: UBERON:0007651 ! anatomical junction intersection_of: RO:0002131 UBERON:0001891 ! overlaps midbrain intersection_of: RO:0002131 UBERON:0002028 ! overlaps hindbrain relationship: BFO:0000050 UBERON:0000955 {source="ZFA"} ! part of brain relationship: RO:0002131 UBERON:0001891 ! overlaps midbrain relationship: RO:0002131 UBERON:0002028 ! overlaps hindbrain relationship: RO:0002495 UBERON:0009615 {source="ZFA"} ! immediate transformation of midbrain hindbrain boundary neural plate property_value: IAO:0000116 "consider adding class for organizer. Consider adding separate class for isthmus as a structure" xsd:string property_value: skos:prefLabel "midbrain-hindbrain boundary" xsd:string [Term] id: UBERON:0003053 name: ventricular zone def: "Proliferative region that is part of the ventricular system." [ZFA:0001083] subset: efo_slim subset: vertebrate_core synonym: "brain ventricular zone" EXACT [MA:0000819] synonym: "ventricular zone of brain" EXACT [] synonym: "ventricular zones" RELATED OMO:0003004 [ZFA:0001083] synonym: "VZ" EXACT [] xref: AAO:0011112 xref: BTO:0003654 xref: DHBA:10542 xref: EFO:0003624 xref: EMAPA:32679 xref: MA:0000819 xref: PBA:294022030 xref: TAO:0001083 xref: VHOG:0001224 xref: XAO:0000021 xref: ZFA:0001083 is_a: BFO:0000004 is_a: UBERON:0000477 ! anatomical cluster relationship: BFO:0000050 UBERON:0000955 {source="MA"} ! part of brain relationship: BFO:0000050 UBERON:0005281 {source="ZFA"} ! part of ventricular system of central nervous system property_value: skos:prefLabel "ventricular zone" xsd:string [Term] id: UBERON:0003054 name: roof plate def: "A single row of glia at the dorsal midline of the developing neural tube along the entire anterior-posterior axis. This region provides inductive signals for the specification of neuronal cell types and of the specification of neural crest cells. The cells comprising the roof plate are the precursors to radial glial cells." [GO:0021509, PMID:15378040] subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "alar plate" RELATED [Wikipedia:Roof_plate] synonym: "future brain roof plate" RELATED [EMAPA:35361] synonym: "roof plate neural tube" EXACT [VHOG:0000303] synonym: "roof plate neural tube region" EXACT [ZFA:0001436] synonym: "roofplate" EXACT [] xref: AAO:0011097 xref: EHDAA2:0001270 xref: EHDAA:2891 xref: EHDAA:916 xref: EMAPA:16168 xref: EMAPA:35361 xref: neuronames:1371 xref: TAO:0001436 xref: TAO:0007058 xref: VHOG:0000303 xref: ZFA:0001436 xref: ZFA:0007058 is_a: BFO:0000002 is_a: UBERON:0000119 ! cell layer is_a: UBERON:0005291 ! embryonic tissue relationship: BSPO:0015101 UBERON:0001049 ! neural tube relationship: RO:0002473 CL:0000125 ! composed primarily of glial cell property_value: IAO:0000116 "TODO - Note that although this is classically defined as being located on the neural tube, in many AOs the roof plate continues post-embryonically after the neural tube has ceased to exist. Consider 'roof plate of neural tube'. TODO - alar plate vs roof plate" xsd:string property_value: skos:prefLabel "roof plate" xsd:string [Term] id: UBERON:0003055 name: periderm def: "The outermost layer (or layers, depending on the species) of embryonic skin, essential for the development of the epidermis and establishment of the barrier functions. The periderm derives from the outer layer of the ectoderm." [ISBN:9780878932504, PMID:25133425, PMID:35582825] subset: pheno_slim subset: uberon_slim synonym: "enveloping layer" RELATED [ZFA:0001185] synonym: "epitrichium" RELATED [MP:0013530, PMID:28722897] synonym: "EVL" RELATED OMO:0003000 [ZFA:0001185] xref: EHDAA2:0001846 xref: EHDAA:6538 xref: FMA:295662 xref: NCIT:C34247 xref: TAO:0001185 xref: UMLS:C1518973 {source="ncithesaurus:Periderm"} xref: VHOG:0001680 xref: XAO:0000029 xref: ZFA:0001185 is_a: UBERON:0000487 {source="EHDAA2"} ! simple squamous epithelium is_a: UBERON:0007376 ! outer epithelium is_a: UBERON:3000961 ! external integument structure property_value: skos:prefLabel "periderm" xsd:string [Term] id: UBERON:0003056 name: pre-chordal neural plate def: "The portion of neural plate anterior to the mid-hindbrain junction." [XB:curator] synonym: "anterior neural plate" RELATED [] xref: AAO:0011084 xref: TAO:0007016 xref: VHOG:0001200 xref: XAO:0000045 xref: ZFA:0007016 is_a: UBERON:0005291 ! embryonic tissue relationship: BFO:0000050 UBERON:0003075 ! part of neural plate relationship: BSPO:0000096 UBERON:0009615 ! midbrain hindbrain boundary neural plate property_value: skos:prefLabel "pre-chordal neural plate" xsd:string [Term] id: UBERON:0003057 name: chordal neural plate def: "The portion of neural plate posterior to the mid-hindbrain junction." [XB:curator] synonym: "posterior neural plate" RELATED [] xref: TAO:0007017 xref: VHOG:0001201 xref: XAO:0000046 xref: ZFA:0007017 is_a: UBERON:0002050 ! embryonic structure relationship: BFO:0000050 UBERON:0003075 ! part of neural plate relationship: BSPO:0000099 UBERON:0009615 ! midbrain hindbrain boundary neural plate property_value: skos:prefLabel "chordal neural plate" xsd:string [Term] id: UBERON:0003059 name: presomitic mesoderm def: "Unsegmented field of paraxial mesoderm present posterior to the most recently formed somite pair, from which somites will form." [ZFIN:curator] subset: efo_slim subset: pheno_slim synonym: "presumptive somite mesoderm" RELATED [] synonym: "PSM" RELATED [] synonym: "segmental plate" EXACT [] synonym: "somitogenic mesoderm" RELATED [] synonym: "somitomeric mesoderm" RELATED [GO:0002075] synonym: "unsegmented mesenchyme" RELATED [VHOG:0000559] synonym: "unsegmented paraxial mesoderm" EXACT [https://orcid.org/0000-0002-6601-2165] xref: AAO:0011086 xref: EFO:0001982 xref: EMAPA:16189 xref: EMAPA:16752 xref: TAO:0000279 xref: VHOG:0000559 xref: XAO:0000057 xref: ZFA:0000279 is_a: BFO:0000002 is_a: UBERON:0000061 ! anatomical structure is_a: UBERON:0006598 ! presumptive structure intersection_of: UBERON:0005423 ! developing anatomical structure intersection_of: RO:0002387 UBERON:0002329 ! has potential to develop into somite intersection_of: RO:0002495 UBERON:0007282 ! immediate transformation of presumptive segmental plate relationship: BFO:0000050 UBERON:0003077 ! part of paraxial mesoderm relationship: RO:0002387 UBERON:0002329 ! has potential to develop into somite relationship: RO:0002495 UBERON:0007282 {source="Bgee:AN"} ! immediate transformation of presumptive segmental plate property_value: skos:prefLabel "presomitic mesoderm" xsd:string [Term] id: UBERON:0003060 name: pronephric duct def: "In mammals, the pronephric duct is the predecessor of the Wolffian duct[WP]." [Wikipedia:Pronephric_duct] comment: The pronephric duct collects the filtrate from the pronephric tubules and opens to the exterior of the pronephric kidney[GOC:mtg_kidney_jan10, PMID:15647339, XAO:0000063, ZFA:0000150] subset: uberon_slim synonym: "archinephric duct" RELATED [VHOG:0000082] synonym: "ductus pronephricus" RELATED OMO:0003011 [Wikipedia:Pronephric_duct] synonym: "pronephric ducts" RELATED OMO:0003004 [ZFA:0000150] xref: AAO:0011088 xref: NCIT:C34279 xref: SCTID:361406002 xref: TAO:0000150 xref: UMLS:C1283945 {source="ncithesaurus:Pronephric_Duct"} xref: Wikipedia:Pronephric_duct xref: XAO:0000063 xref: ZFA:0000150 is_a: UBERON:0009201 {source="GO"} ! nephric duct relationship: BFO:0000050 UBERON:0002120 ! part of pronephros relationship: RO:0002202 UBERON:0003064 {source="Wikipedia"} ! develops from intermediate mesoderm relationship: RO:0002202 UBERON:0005721 {source="XAO"} ! develops from pronephric mesoderm [Term] id: UBERON:0003061 name: blood island def: "Blood islands are structures in the developing embryo which lead to many different parts of the circulatory system. They primarily derive from plexuses formed from angioblasts. Within them, vacuoles appear through liquefaction of the central part of the syncytium into plasma. The lumen of the blood vessels thus formed is probably intracellular. The flattened cells at the periphery form the endothelium. The nucleated red blood corpuscles develop either from small masses of the original angioblast left attached to the inner wall of the lumen or directly from the flat endothelial cells. In either case the syncytial mass thus formed projects from and is attached to the wall of the vessel. Such a mass is known as a blood island and hemoglobin gradually accumulates within it. Later the cells on the surface round up, giving the mass a mulberry-like appearance. Then the red blood cells break loose and are carried away in the plasma. Such free blood cells continue to divide. Blood islands have been seen in the area vasculosa in the omphalomesenteric vein and arteries, and in the dorsal aorta[WP, unvetted]." [Wikipedia:Blood_island_of_umbilical_vesicle] subset: efo_slim subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "blood islands" EXACT OMO:0003004 [] synonym: "caudal hematopoietic tissue" RELATED [] synonym: "posterior blood island" RELATED [] synonym: "posterior ICM" RELATED [] synonym: "VBI" RELATED [] synonym: "ventral blood island" RELATED [] synonym: "ventral lateral plate mesoderm" BROAD [] xref: AAO:0011006 xref: EFO:0003489 xref: EHDAA:207 xref: NCIT:C34113 xref: TAO:0000094 xref: TE:E5.11.2.0.0.0.4 xref: UMLS:C1511224 {source="ncithesaurus:Blood_Island"} xref: VHOG:0000085 xref: Wikipedia:Blood_island_of_umbilical_vesicle xref: XAO:0000067 xref: ZFA:0000094 is_a: BFO:0000002 is_a: UBERON:0006598 ! presumptive structure relationship: RO:0002202 UBERON:0003081 ! develops from lateral plate mesoderm relationship: RO:0002387 UBERON:0002390 ! has potential to develop into hematopoietic system property_value: skos:prefLabel "blood island" xsd:string [Term] id: UBERON:0003063 name: prechordal plate def: "A horseshoe-shaped thickening of the endoderm at the cranial (rostral) end of the primitive streak formed by the involution of Spemann's organizer cells which, together with the notochord, induces the formation of the neural plate from the overlying ectodermal cells and contributes mesodermal type cells to the surrounding tissue." [ISBN:0838580343, MP:0004387] subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "head mesenchyme" BROAD [XAO:0000079] synonym: "head mesoderm" BROAD [XAO:0000079] xref: AAO:0011085 xref: EHDAA2:0001493 xref: EHDAA:181 xref: FMA:295532 xref: TAO:0000060 xref: VHOG:0000086 xref: Wikipedia:Prechordal_plate xref: XAO:0000079 xref: ZFA:0000060 is_a: BFO:0000002 is_a: UBERON:0002050 ! embryonic structure relationship: BFO:0000050 UBERON:0003068 {source="ZFA"} ! part of axial mesoderm relationship: RO:0002494 UBERON:0034878 ! transformation of prechordal mesoderm property_value: IAO:0000116 "TODO - check; developmental relationship to anterior hypoblast in ZFA?" xsd:string property_value: skos:prefLabel "prechordal plate" xsd:string [Term] id: UBERON:0003064 name: intermediate mesoderm def: "The intermediate mesoderm is located between the lateral mesoderm and the paraxial mesoderm. It develops into the kidney and gonads." [GOC:curators, Wikipedia:Intermediate_mesoderm] subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "IM" RELATED [] synonym: "intermediate mesenchyme" RELATED [https://github.com/obophenotype/uberon/wiki/The-neural-crest] synonym: "intermediate plate" RELATED [EMAPA:16178] synonym: "intermediate plate mesoderm" RELATED [https://orcid.org/0000-0002-6601-2165] synonym: "mesenchyma intermedium" RELATED OMO:0003011 [Wikipedia:Intermediate_mesoderm] xref: AAO:0010575 xref: EMAPA:16056 xref: EMAPA:16178 xref: FMA:293147 xref: NCIT:C34193 xref: SCTID:361476001 xref: TAO:0001206 xref: UMLS:C1284010 {source="ncithesaurus:Intermediate_Mesoderm"} xref: VHOG:0000087 xref: Wikipedia:Intermediate_mesoderm xref: XAO:0000085 xref: ZFA:0001206 is_a: BFO:0000002 is_a: UBERON:0002050 ! embryonic structure relationship: BFO:0000050 UBERON:0000926 {source="AAO"} ! part of mesoderm relationship: BFO:0000050 UBERON:0005256 {source="EMAPA"} ! part of trunk mesenchyme relationship: RO:0002202 UBERON:0000926 {source="XAO"} ! develops from mesoderm relationship: RO:0002220 UBERON:0003077 ! adjacent to paraxial mesoderm relationship: RO:0002220 UBERON:0003081 ! adjacent to lateral plate mesoderm property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/6/64/Gray19_with_color.png" xsd:anyURI property_value: skos:prefLabel "intermediate mesoderm" xsd:string [Term] id: UBERON:0003066 name: pharyngeal arch 2 def: "The second pharyngeal arch will form the hyoid apparatus. The cranial neural crest cells that populate the second pharyngeal arch emerge primarily from rhombomere 4 and will form skeletal elements." [https://github.com/obophenotype/uberon/issues/258, PMID:12784288, ZFIN:yb] subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "2nd arch" RELATED [EHDAA2:0000050] synonym: "2nd pharyngeal arch" EXACT [] synonym: "2nd visceral arch" RELATED [VHOG:0000297] synonym: "arcus pharyngeus secundus" EXACT OMO:0003011 [Wikipedia:Second_pharyngeal_arch] synonym: "branchial arch 2" EXACT SENSU [] synonym: "hyoid arch" EXACT [XAO:0000098] synonym: "hyoid bars" RELATED [] synonym: "pharyngeal arch 2" EXACT [] synonym: "pharyngeal arches 2" RELATED [VHOG:0000297] synonym: "second branchial arch" EXACT SENSU [] synonym: "second pharyngeal arch" EXACT [] synonym: "second visceral arch" EXACT SENSU [] synonym: "visceral arch 2" EXACT SENSU [] xref: AAO:0010363 xref: EHDAA2:0000050 xref: EHDAA:611 xref: EMAPA:16272 xref: FMA:293017 xref: NCIT:C34288 xref: SCTID:308768003 xref: TAO:0001596 xref: VHOG:0000297 xref: Wikipedia:Second_pharyngeal_arch xref: XAO:0000098 xref: ZFA:0001611 is_a: UBERON:0002539 ! pharyngeal arch property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/8/8b/Gray41.png" xsd:anyURI property_value: skos:prefLabel "pharyngeal arch 2" xsd:string [Term] id: UBERON:0003067 name: dorsolateral placode def: "Lateral neurogenic placodes positioned dorsal of the epibranchial placodes." [ZFIN:curator] comment: The only remaining dorsolateral placode in land vertebrates is the otic/octaval placode synonym: "dorsolateral placodes" EXACT OMO:0003004 [ZFA:0001310] xref: TAO:0001310 xref: VHOG:0000103 xref: XAO:0000187 xref: ZFA:0001310 is_a: UBERON:0009955 {source="NCBIBook:NBK53175"} ! neurogenic placode relationship: BSPO:0000098 UBERON:0003078 ! epibranchial placode property_value: skos:prefLabel "dorsolateral placode" xsd:string [Term] id: UBERON:0003068 name: axial mesoderm def: "The axial mesoderm includes the prechordal mesoderm and the chordamesoderm. It gives rise to the prechordal plate and to the notochord." [GO:0048318, Wikipedia:Chordamesoderm] subset: efo_slim subset: uberon_slim synonym: "chordamesoderm" RELATED [Wikipedia:Chordamesoderm] xref: AAO:0011017 xref: EFO:0003647 xref: TAO:0001204 xref: VHOG:0000107 xref: Wikipedia:Chordamesoderm xref: XAO:0000205 xref: ZFA:0001204 is_a: BFO:0000002 is_a: UBERON:0002050 ! embryonic structure relationship: BFO:0000050 UBERON:0000926 ! part of mesoderm relationship: RO:0002162 NCBITaxon:7711 ! in taxon Chordata relationship: RO:0002202 UBERON:0000926 ! develops from mesoderm property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/6/64/Gray19_with_color.png" xsd:anyURI property_value: skos:prefLabel "axial mesoderm" xsd:string [Term] id: UBERON:0003069 name: otic placode def: "A cranial placode which, once specified, invaginates to form an otic cup, which eventually separates from the surface ectoderm to form the otic vesicle or otocyst, a rounded structure without appar- ent polarity. As the otic placode invaginates into a cup neuroblasts delaminate from the anterior ventral aspect of the otic epithelium to give rise to neurons of the vestibulocochlear (statoacoustic) ganglion of cranial nerve VIII[NBK]." [NCBIBook:NBK53175, Wikipedia:Otic_placode] subset: efo_slim subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "auditory placode" RELATED [] synonym: "ear placode" RELATED [] synonym: "ear/otic placode" RELATED [] synonym: "octaval placode" RELATED [ISBN:0471888893] synonym: "octaval VIII placode" RELATED [ISBN:0471888893] synonym: "placoda otica" EXACT OMO:0003011 [] xref: AAO:0011079 xref: EFO:0003429 xref: EHDAA2:0001339 xref: EHDAA:506 xref: EMAPA:16195 xref: FMA:293973 xref: NCIT:C34239 xref: TAO:0000138 xref: UMLS:C1518677 {source="ncithesaurus:Otic_Placodes"} xref: VHOG:0000235 xref: Wikipedia:Otic_placode xref: XAO:0000223 xref: ZFA:0000138 is_a: UBERON:0003067 ! dorsolateral placode relationship: BFO:0000050 UBERON:0001690 ! part of ear property_value: skos:prefLabel "otic placode" xsd:string [Term] id: UBERON:0003070 name: trigeminal placode complex def: "A neurogenic placode that arises at the level of the midbrain-hindbrain boundary and develops into a trigeminal ganglion." [http://orcid.org/0000-0002-6601-2165, https://github.com/obophenotype/uberon/issues/693, PMID:22512454] subset: efo_slim synonym: "profundus placode" RELATED INCONSISTENT [ISBN:0471888893] synonym: "profundus V placode" RELATED INCONSISTENT [ISBN:0471888893] synonym: "trigeminal placode" EXACT [EHDAA2:0004209, VHOG:0000109, XAO:0000225, ZFA:0000162] synonym: "trigeminal placodes" RELATED OMO:0003004 [ZFA:0000162] synonym: "trigeminal V placode" EXACT [] xref: EFO:0003433 xref: EHDAA2:0004209 xref: TAO:0000162 xref: VHOG:0000109 xref: XAO:0000225 xref: ZFA:0000162 is_a: UBERON:0003067 {source="ISBN:0471888893"} ! dorsolateral placode relationship: RO:0002385 UBERON:0003942 ! has potential to developmentally contribute to somatosensory system property_value: skos:prefLabel "trigeminal placode complex" xsd:string property_value: terms:contributor https://orcid.org/0000-0001-9114-8737 property_value: terms:contributor https://orcid.org/0000-0002-6601-2165 property_value: terms:contributor https://orcid.org/0000-0003-3308-6245 [Term] id: UBERON:0003071 name: eye primordium def: "Portion of tissue that is part of the anterior neural keel and will form the optic vesicle[ZFA]. A paired ectodermal placode that becomes invaginated to form the embryonic lens vesicles." [GO:0046619, ZFA:0000570] subset: efo_slim synonym: "eye anlage" RELATED [XAO:0000227] synonym: "eye field" RELATED [] synonym: "eye placode" EXACT [OBOL:automatic] synonym: "occular primordium" EXACT [] synonym: "ocular primordium" EXACT [] synonym: "optic field" RELATED [] synonym: "optic placode" EXACT [GO:0046619] synonym: "optic placode of camera-type eye" EXACT [GO:0046619, https://orcid.org/0000-0002-6601-2165] synonym: "optic placodes" RELATED OMO:0003004 [] synonym: "optic primordium" EXACT [] xref: AAO:0011038 xref: EFO:0003541 xref: EHDAA2:0004431 xref: TAO:0000570 xref: XAO:0000227 xref: XAO:0004090 xref: ZFA:0000570 is_a: BFO:0000002 is_a: UBERON:0000490 {source="EHDAA2"} ! unilaminar epithelium is_a: UBERON:0001048 ! primordium is_a: UBERON:0005291 ! embryonic tissue is_a: UBERON:0006598 ! presumptive structure intersection_of: UBERON:0001048 ! primordium intersection_of: RO:0002387 UBERON:0000019 ! has potential to develop into camera-type eye relationship: BFO:0000050 UBERON:0003056 {source="PMID:16496288", source="XAO"} ! part of pre-chordal neural plate relationship: RO:0002202 UBERON:0003056 ! develops from pre-chordal neural plate relationship: RO:0002387 UBERON:0000019 ! has potential to develop into camera-type eye property_value: skos:prefLabel "eye primordium" xsd:string [Term] id: UBERON:0003072 name: optic cup def: "Multi-tissue structure that is comprised of neural and non-neural epithelial layers which will form the retina and retinal pigmented epithelium of the mature eye[ZFA]. double walled structured formed by expansion and invagination of the distal end of the optic vesicle that develops into the pigmented and sensory layers of the retina while the mouth of the optic cup eventually forms the pupil of the eye[MP]." [MP:0004269, Wikipedia:Optic_cup_(embryology), ZFA:0001202] subset: pheno_slim subset: vertebrate_core synonym: "eye cup" RELATED [] synonym: "eyecup" RELATED [BTO:0005351] synonym: "ocular cup" RELATED [VHOG:0000167] synonym: "ophtalmic cup" RELATED [BTO:0005351] xref: BTO:0005351 xref: EHDAA2:0001303 xref: EHDAA:2912 xref: EMAPA:16674 xref: NCIT:C34233 xref: SCTID:308789007 xref: TAO:0001202 xref: UMLS:C0231109 {source="ncithesaurus:Optic_Cup"} xref: VHOG:0000167 xref: ZFA:0001202 is_a: UBERON:0000481 ! multi-tissue structure is_a: UBERON:0004121 ! ectoderm-derived structure relationship: BFO:0000050 UBERON:0010312 {source="ZFA"} ! part of immature eye relationship: RO:0002202 UBERON:0004128 {source="ZFA"} ! develops from optic vesicle relationship: RO:0002256 UBERON:0003073 ! developmentally induced by lens placode property_value: skos:prefLabel "optic cup" xsd:string [Term] id: UBERON:0003073 name: lens placode def: "A thickened portion of ectoderm which serves as the precursor to the lens. SOX2 and Pou2f1 are involved in its development[WP]." [Wikipedia:Lens_placode, ZFIN:curator] subset: efo_slim subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "lens placodes" RELATED OMO:0003004 [ZFA:0000122] synonym: "placoda lentis" RELATED OMO:0003011 [Wikipedia:Lens_placode] xref: AAO:0011055 xref: EFO:0003494 xref: EHDAA2:0000982 xref: EHDAA:2908 xref: EMAPA:16672 xref: FMA:296767 xref: NCIT:C34202 xref: TAO:0000122 xref: UMLS:C1517770 {source="ncithesaurus:Lens_Placodes"} xref: VHOG:0000166 xref: Wikipedia:Lens_placode xref: XAO:0000240 xref: ZFA:0000122 is_a: BFO:0000002 is_a: UBERON:0002546 ! cranial placode is_a: UBERON:0006598 ! presumptive structure is_a: UBERON:0011814 {source="NCBIBook:NBK53175"} ! non-neurogenic ectodermal placode intersection_of: UBERON:0005085 ! ectodermal placode intersection_of: RO:0002387 UBERON:0000965 ! has potential to develop into lens of camera-type eye relationship: BFO:0000050 UBERON:0010312 {source="ZFA"} ! part of immature eye relationship: RO:0002256 UBERON:0004128 ! developmentally induced by optic vesicle relationship: RO:0002387 UBERON:0000965 ! has potential to develop into lens of camera-type eye property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/2/2f/Gray864.png" xsd:anyURI property_value: skos:prefLabel "lens placode" xsd:string [Term] id: UBERON:0003074 name: mesonephric duct def: "Paired organ that connects the primitive kidney Wolffian body (or mesonephros) to the cloaca and serves as the anlage for certain male reproductive organs. the Wolffian duct is what remains of the pronephric duct after the atrophy of the pronephros[WP]. In Zebrafish: Duct of the adult kidney (mesonephros), present bilaterally ventral to the somites and leading to the cloacal chamber[ZFA]." [https://github.com/obophenotype/uberon/issues/28, Wikipedia:Mesonephric_duct, ZFIN:curator] subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "archinephric duct" RELATED [VHOG:0000082, Wikipedia:Wolffian_duct] synonym: "ductus mesonephricus; ductus Wolffi" RELATED OMO:0003011 [Wikipedia:Mesonephric_duct] synonym: "Leydig's duct" RELATED [Wikipedia:Wolffian_duct] synonym: "renal duct" RELATED [] synonym: "Wolffian duct" EXACT [GOC:yaf, Wikipedia:Wolffian_duct, ZFA:0000546] xref: AAO:0000637 xref: EHDAA2:0001243 xref: EHDAA:1590 xref: GAID:1315 xref: MESH:D014928 xref: NCIT:C26469 xref: SCTID:308800003 xref: TAO:0000546 xref: UMLS:C0043204 {source="ncithesaurus:Mesonephric_Duct"} xref: Wikipedia:Mesonephric_duct xref: XAO:0000242 xref: ZFA:0000546 is_a: UBERON:0000083 ! mesonephric tubule is_a: UBERON:0009201 {source="GO"} ! nephric duct relationship: RO:0002202 UBERON:0003060 ! develops from pronephric duct relationship: RO:0002202 UBERON:0005792 {source="EHDAA2"} ! develops from nephric ridge property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/6/6d/Gray1109.png" xsd:anyURI property_value: IAO:0000116 "Consider adding subclasses for male and female specific variants" xsd:string property_value: IAO:0000116 "TODO - mesonephric portion of the nephric duct" xsd:string property_value: terms:contributor https://orcid.org/0000-0002-6601-2165 [Term] id: UBERON:0003075 name: neural plate def: "A region of embryonic ectodermal cells that lie directly above the notochord. During neurulation, they change shape and produce an infolding of the neural plate (the neural fold) that then seals to form the neural tube[XAO]. The earliest recognizable dorsal ectodermal primordium of the central nervous system present near the end of gastrulation before infolding to form the neural keel; consists of a thickened pseudostratified epithelium[ZFA]." [ISBN:0815318960, OMD:neural+plate, Wikipedia:Neural_plate, ZFIN:curator] subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "lamina neuralis" RELATED OMO:0003011 [Wikipedia:Neural_plate] synonym: "presumptive central nervous system" RELATED [] xref: AAO:0011072 xref: BTO:0001765 xref: DHBA:10153 xref: DMBA:15565 xref: EHDAA:346 xref: EHDAA:902 xref: EMAPA:35593 xref: FMA:293879 xref: NCIT:C34225 xref: neuronames:1362 xref: RETIRED_EHDAA2:0001252 xref: TAO:0000132 xref: UMLS:C0920623 {source="ncithesaurus:Neural_Plate"} xref: VHOG:0000068 xref: Wikipedia:Neural_plate xref: XAO:0000249 xref: ZFA:0000132 is_a: UBERON:0005291 ! embryonic tissue is_a: UBERON:0010371 ! ecto-epithelium is_a: UBERON:0016879 ! future central nervous system relationship: RO:0002256 UBERON:0002328 {source="Wikipedia"} ! developmentally induced by notochord relationship: RO:0002495 UBERON:0007284 {source="Bgee:AN"} ! immediate transformation of presumptive neural plate property_value: foaf:depiction "https://upload.wikimedia.org/wikipedia/commons/8/8f/Neural_Crest.png" xsd:anyURI property_value: skos:prefLabel "neural plate" xsd:string [Term] id: UBERON:0003076 name: posterior neural tube xref: AAO:0011082 xref: TAO:0007037 xref: VHOG:0001383 xref: XAO:0000250 xref: ZFA:0007037 is_a: BFO:0000002 is_a: UBERON:0002050 ! embryonic structure disjoint_from: UBERON:0003080 {source="lexical"} ! anterior neural tube relationship: BFO:0000050 UBERON:0001049 ! part of neural tube relationship: RO:0002202 UBERON:0003057 ! develops from chordal neural plate property_value: skos:prefLabel "posterior neural tube" xsd:string [Term] id: UBERON:0003077 name: paraxial mesoderm def: "The paraxial mesoderm is the mesoderm located bilaterally adjacent to the notochord and neural tube[GO]." [GO:0048339, https://github.com/obophenotype/uberon/issues/30] subset: efo_slim subset: uberon_slim subset: vertebrate_core synonym: "mesoderma paraxiale" RELATED OMO:0003011 [Wikipedia:Paraxial_mesoderm] synonym: "paraxial mesenchyme" EXACT [https://github.com/obophenotype/uberon/issues/30, https://github.com/obophenotype/uberon/wiki/The-neural-crest, ZFA:0000255] synonym: "somitic mesoderm" EXACT [ISBN:9780878932504] xref: AAO:0010568 xref: EFO:0003515 xref: EMAPA:16183 xref: EMAPA:16751 xref: FMA:293145 xref: NCIT:C34244 xref: SCTID:361475002 xref: TAO:0000255 xref: UMLS:C1284009 {source="ncithesaurus:Paraxial_Mesoderm"} xref: VHOG:0000114 xref: Wikipedia:Paraxial_mesoderm xref: XAO:0000259 xref: ZFA:0000255 is_a: UBERON:0005291 ! embryonic tissue is_a: UBERON:0007524 {source="EHDAA2"} ! dense mesenchyme tissue is_a: UBERON:0015212 ! lateral structure relationship: BSPO:0000126 UBERON:0000922 ! embryo relationship: RO:0002488 UBERON:0000109 ! existence starts during gastrula stage relationship: RO:0002495 UBERON:0007285 {source="Bgee:AN"} ! immediate transformation of presumptive paraxial mesoderm property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/6/64/Gray19_with_color.png" xsd:anyURI property_value: skos:prefLabel "paraxial mesoderm" xsd:string [Term] id: UBERON:0003078 name: epibranchial placode def: "Focal thickenings of the embryonic ectoderm that form immediately dorsal and caudal of the clefts between the pharyngeal arches and that produce the neuroblasts that migrate and condense to form the distal cranial ganglia." [VHOG:0000117] subset: efo_slim synonym: "epibranchial placodes" EXACT OMO:0003004 [ZFA:0001294] synonym: "ventrolateral placode" RELATED [ISBN:0471888893] xref: AAO:0011036 xref: EFO:0003455 xref: FMA:293968 xref: TAO:0001294 xref: VHOG:0000117 xref: XAO:0000284 xref: ZFA:0001294 is_a: UBERON:0009955 {source="NCBIBook:NBK53175", source="ZFA"} ! neurogenic placode relationship: BFO:0000050 UBERON:0000010 {source="ZFA"} ! part of peripheral nervous system relationship: RO:0002202 UBERON:0000076 {source="EHDAA2-abduced"} ! develops from external ectoderm relationship: RO:0002385 UBERON:0002410 ! has potential to developmentally contribute to autonomic nervous system property_value: skos:prefLabel "epibranchial placode" xsd:string [Term] id: UBERON:0003079 name: floor plate def: "The specialized glial structure (non-neuronal cells) situated at the ventral midline of the embryonic neural tube; this structure spans the anteroposterior axis from the midbrain to the tail regions, separating the left and right basal plates of the developing neural tube, and serves as an organizer to ventralize tissues in the embryo as well as to guide neuronal positioning and differentiation along the dorsoventral axis of the neural tube." [GO:0021508, MGI:anna, PMID:15738958, Wikipedia:Floor_plate] comment: "A structure integral to the developing nervous system of vertebrate organisms. Located on the ventral midline of the embryonic neural tube, the floor plate is a specialized glial structure that spans the anteroposterior axis from the midbrain to the tail regions. It has been shown that the floor plate is conserved among vertebrates with homologous structures in invertebrates such as the fruit fly Drosophila and the nematode C. elegans. Functionally, the structure serves as an organizer to ventralize tissues in the embryo as well as to guide neuronal positioning and differentiation along the dorsoventral axis of the neural tube." {source="Wikipedia:Floor_plate"} subset: efo_slim subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "bodenplatte" RELATED [BTO:0001720] synonym: "floorplate" EXACT [] synonym: "FP" RELATED [TAO:0000022] synonym: "ventral plate" RELATED [BTO:0001720] xref: AAO:0011041 xref: BTO:0001720 xref: EFO:0003473 xref: EMAPA:32684 xref: RETIRED_EHDAA2:0000545 xref: TAO:0000022 xref: Wikipedia:Floor_plate xref: ZFA:0000022 is_a: UBERON:0000119 ! cell layer is_a: UBERON:0004121 ! ectoderm-derived structure is_a: UBERON:0005291 ! embryonic tissue relationship: BSPO:0015102 UBERON:0001049 ! neural tube relationship: RO:0002202 UBERON:0002328 {source="Wikipedia"} ! develops from notochord relationship: RO:0002473 CL:0000125 ! composed primarily of glial cell relationship: RO:0002495 UBERON:0007286 ! immediate transformation of presumptive floor plate relationship: RO:0003000 PR:000015557 ! produces spondin-1 property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/8/89/Gray642.png" xsd:anyURI property_value: skos:prefLabel "floor plate" xsd:string [Term] id: UBERON:0003080 name: anterior neural tube xref: AAO:0011012 xref: TAO:0007038 xref: VHOG:0001384 xref: XAO:0000307 xref: ZFA:0007038 is_a: BFO:0000002 is_a: UBERON:0002050 ! embryonic structure relationship: BFO:0000050 UBERON:0001049 ! part of neural tube relationship: RO:0002202 UBERON:0003056 ! develops from pre-chordal neural plate property_value: IAO:0000116 "TODO - add grouping class for the anterior end of the neural tube at all stages" xsd:string property_value: skos:prefLabel "anterior neural tube" xsd:string [Term] id: UBERON:0003081 name: lateral plate mesoderm def: "Portion of the middle of the three primary germ layers of the embryo that resides on the periphery of the embryo, is continuous with the extra-embryonic mesoderm, splits into two layers enclosing the intra-embryonic coelom, and gives rise to body wall structures[MP]." [MP:0010117, Wikipedia:Lateral_plate_mesoderm] subset: pheno_slim subset: uberon_slim synonym: "lateral mesoderm" EXACT [GO:0048368] synonym: "lateral plate" RELATED [] synonym: "lateral plate mesenchyme" RELATED [EHDAA2:0000919] synonym: "LPM" EXACT OMO:0003000 [ZFA:0000121] synonym: "mesoderma laminae lateralis" RELATED OMO:0003011 [Wikipedia:Lateral_plate_mesoderm] xref: AAO:0010574 xref: EHDAA2:0000919 xref: EHDAA:379 xref: EMAPA:16179 xref: FMA:293149 xref: NCIT:C34199 xref: SCTID:361477005 xref: TAO:0000121 xref: UMLS:C1517749 {source="ncithesaurus:Lateral_Mesoderm"} xref: VHOG:0000118 xref: Wikipedia:Lateral_plate_mesoderm xref: XAO:0000311 xref: ZFA:0000121 is_a: UBERON:0002050 ! embryonic structure is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0005291 ! embryonic tissue is_a: UBERON:0007524 {source="EHDAA2"} ! dense mesenchyme tissue relationship: BFO:0000050 UBERON:0000926 {source="EHDAA2", source="VHOG"} ! part of mesoderm relationship: RO:0002162 NCBITaxon:33213 ! in taxon Bilateria relationship: RO:0002221 UBERON:0003887 ! surrounds intraembryonic coelom property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/6/64/Gray19_with_color.png" xsd:anyURI property_value: skos:prefLabel "lateral plate mesoderm" xsd:string [Term] id: UBERON:0003082 name: myotome def: "A transitional population of migrating mesenchymal cells that derive from somites and that will become muscle cells." [AEO:0001018] subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "muscle plate" RELATED [] synonym: "myomere" RELATED [] synonym: "myomeres" EXACT OMO:0003004 [TAO:0001056] synonym: "myotome region" RELATED [] synonym: "myotomes" RELATED [] synonym: "myotomus" RELATED OMO:0003011 [Wikipedia:Myotome] xref: AAO:0011067 xref: AEO:0001018 xref: BTO:0000742 xref: EHDAA2_RETIRED:0003431 xref: EHDAA:1721 xref: EHDAA:1727 xref: EHDAA:1733 xref: EHDAA:1739 xref: EMAPA:32841 xref: FMA:295658 xref: NCIT:C34214 xref: SCTID:344535001 xref: TAO:0001056 xref: UMLS:C1513802 {source="ncithesaurus:Myotome_Region"} xref: VHOG:0001244 xref: Wikipedia:Myotome xref: XAO:0000315 xref: ZFA:0001056 is_a: BFO:0000002 is_a: UBERON:0017650 {source="AEO"} ! developing mesenchymal structure relationship: RO:0002202 UBERON:0004290 {source="EHDAA2-abduced"} ! develops from dermomyotome relationship: RO:0002433 UBERON:0001630 ! contributes to morphology of muscle organ property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/9/96/Gray65.png" xsd:anyURI property_value: IAO:0000116 "The term 'myotome' is also used to describe the muscles served by a single nerve root / spinal segment - consider adding new class, myomere." xsd:string property_value: skos:prefLabel "myotome" xsd:string [Term] id: UBERON:0003083 name: trunk neural crest def: "Trunk portion of the neural crest. The trunk neural crest lies between the vagal and sacral neural crest and gives rise to two groups of cells. One group migrates dorsolateral and populates the skin, forming pigment cells and the other migrates ventrolateral through the anterior sclerotome to become the epinephrine-producing cells of the adrenal gland and the neurons of the sympathetic nervous system. Some cells remain in the sclerotome to form the dorsal root ganglia [Wikipedia]." [ISBN:0815318960, Wikipedia:Trunk_neural_crest] subset: efo_slim subset: uberon_slim synonym: "TNC" EXACT OMO:0003000 [XAO:0000319] synonym: "trunk crest" RELATED [] xref: AAO:0010582 xref: EFO:0003605 xref: EHDAA2:0001901 xref: TAO:0001024 xref: VHOG:0000062 xref: Wikipedia:Trunk_neural_crest xref: XAO:0000319 xref: ZFA:0001024 is_a: BFO:0000002 is_a: UBERON:0005291 ! embryonic tissue relationship: BFO:0000050 UBERON:0002342 ! part of neural crest relationship: BFO:0000051 CL:0000011 {source="ZFA"} ! has part migratory trunk neural crest cell property_value: skos:prefLabel "trunk neural crest" xsd:string [Term] id: UBERON:0003084 name: heart primordium def: "Bilateral groups of cells consisting of three rows: one row of endocardial precursors medially and two rows of myocardical precursors laterally. The two populations fuse at the midline to form the heart rudiment or cone." [ZFIN:curator] subset: uberon_slim synonym: "cardiac field" RELATED [ZFA:0000028] synonym: "fused heart primordium" RELATED [] xref: AAO:0011044 xref: BTO:0001887 xref: NCIT:C34276 xref: TAO:0000028 xref: UMLS:C1514450 {source="ncithesaurus:Primordium_of_the_Heart"} xref: XAO:0000336 xref: ZFA:0000028 is_a: BFO:0000002 is_a: UBERON:0001048 {source="Obol"} ! primordium relationship: BFO:0000050 UBERON:0004535 {source="ZFA"} ! part of cardiovascular system relationship: RO:0002202 UBERON:0003081 {source="ZFA"} ! develops from lateral plate mesoderm relationship: RO:0002202 UBERON:0004140 ! develops from primary heart field relationship: RO:0002202 UBERON:0007005 {source="XAO"} ! develops from cardiogenic splanchnic mesoderm property_value: IAO:0000116 "should probably be merged with heart rudiment." xsd:string property_value: skos:prefLabel "heart primordium" xsd:string [Term] id: UBERON:0003086 name: caudal artery def: "Extension of the dorsal aorta in the tail." [Wikipedia:Caudal_artery, ZFIN:curator] subset: efo_slim subset: uberon_slim synonym: "CA" RELATED [] xref: AAO:0011023 xref: EFO:0003472 xref: TAO:0000011 xref: VHOG:0000123 xref: Wikipedia:Caudal_artery xref: XAO:0000364 xref: ZFA:0000011 is_a: UBERON:0001637 ! artery is_a: UBERON:0003524 ! tail blood vessel intersection_of: UBERON:0001637 ! artery intersection_of: BFO:0000050 UBERON:0007812 ! part of post-anal tail intersection_of: RO:0002252 UBERON:0005805 ! connecting branch of dorsal aorta relationship: BFO:0000050 UBERON:2001073 ! part of axial vasculature relationship: RO:0002252 UBERON:0005805 ! connecting branch of dorsal aorta property_value: skos:prefLabel "caudal artery" xsd:string [Term] id: UBERON:0003089 name: sclerotome def: "Ventral somitic compartment that is a precursor of the axial skeleton[XAO]. Sclerotomes eventually differentiate into the vertebrae and most of the skull. The caudal (posterior) half of one sclerotome fuses with the rostral (anterior) half of the adjacent one to form each vertebra. From their initial location within the somite, the sclerotome cells migrate medially towards the notochord. These cells meet the sclerotome cells from the other side to form the vertebral body. From this vertebral body, sclerotome cells move dorsally and surround the developing spinal cord, forming the vertebral arch[WP]." [https://github.com/obophenotype/uberon/issues/316, Wikipedia:Sclerotome, XB:curator] subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "sclerotomes" EXACT OMO:0003004 [TAO:0001080] synonym: "sclerotomus" RELATED OMO:0003011 [Wikipedia:Sclerotome] xref: AAO:0010571 xref: AEO:0000212 xref: EHDAA2:0003439 xref: EMAPA:31159 xref: FMA:295652 xref: NCIT:C34287 xref: TAO:0001080 xref: UMLS:C0183176 {source="ncithesaurus:Sclerotome"} xref: VHOG:0000680 xref: Wikipedia:Sclerotome xref: XAO:0000397 xref: ZFA:0001080 is_a: UBERON:0005856 {source="EHDAA2"} ! developing mesenchymal condensation is_a: UBERON:0007530 {source="EHDAA2"} ! migrating mesenchyme population relationship: RO:0002162 NCBITaxon:7742 {source="VHOG:0000680"} ! in taxon Vertebrata relationship: RO:0002202 UBERON:0002329 {source="ZFA"} ! develops from somite property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/9/96/Gray65.png" xsd:anyURI property_value: skos:prefLabel "sclerotome" xsd:string [Term] id: UBERON:0003091 name: thyroid primordium def: "The initial thyroid precursor, the thyroid primordium, starts as a simple midline thickening and develops to form the thyroid diverticulum. This structure is initially hollow, although it later solidifies and becomes bilobed. The 2 lobes are located on either side of the midline and are connected via an isthmus." [http://emedicine.medscape.com/article/845125-overview] subset: vertebrate_core synonym: "thyroid primordia" RELATED OMO:0003004 [ZFA:0001081] xref: AAO:0011106 xref: BTO:0004709 xref: EHDAA2:0002033 xref: EHDAA:952 xref: EMAPA:16361 xref: NCIT:C34312 xref: TAO:0001081 xref: UMLS:C1519512 {source="ncithesaurus:Thyroid_Primordium"} xref: XAO:0000444 xref: ZFA:0001081 is_a: UBERON:0000479 {source="ZFA"} ! tissue is_a: UBERON:0001048 ! primordium is_a: UBERON:0004119 ! endoderm-derived structure relationship: BFO:0000050 UBERON:0000949 {source="ZFA"} ! part of endocrine system relationship: BFO:0000050 UBERON:0001042 {source="VHOG"} ! part of chordate pharynx relationship: RO:0002202 UBERON:0007123 {source="ISBN:0073040584", source="PMID:16313389"} ! develops from pharyngeal pouch 2 [Term] id: UBERON:0003098 name: optic stalk def: "The narrow, proximal portion of the optic vesicle which connects the embryonic eye and forebrain." [ISBN:0-914294-08-3, MP:0004268] subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "optic stalks" RELATED OMO:0003004 [ZFA:0000137] synonym: "pedunculus opticus" RELATED OMO:0003011 [Wikipedia:Optic_stalk] xref: AAO:0011077 xref: EHDAA2:0001318 xref: EHDAA:3816 xref: EMAPA:16678 xref: NCIT:C34235 xref: SCTID:308788004 xref: TAO:0000137 xref: UMLS:C0231107 {source="ncithesaurus:Optic_Stalk"} xref: VHOG:0000223 xref: Wikipedia:Optic_stalk xref: XAO:0000475 xref: ZFA:0000137 is_a: UBERON:0010371 ! ecto-epithelium is_a: UBERON:0034705 {source="EHDAA2"} ! developing neuroepithelium relationship: BFO:0000050 UBERON:0001894 ! part of diencephalon relationship: RO:0002202 UBERON:0003072 ! develops from optic cup property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/2/2f/Gray864.png" xsd:anyURI property_value: skos:prefLabel "optic stalk" xsd:string [Term] id: UBERON:0003099 name: cranial neural crest def: "Neural crest cells (NCCs) originating in the anterior part of the developing embryo and residing between the mid-diencephalon and the forming hindbrain; cranial NCCs migrate dorsolaterally to form the craniofacial mesenchyme that differentiates into various craniofacial cartilages and bones, cranial neurons, glia, and connective tissues of the face; these cells enter the pharyngeal pouches and arches where they give rise to thymic cells, bones of the middle ear and jaw (mandible), and the odontoblasts of the tooth primordia; like their counterparts in the trunk, cranial NCCs also contribute to the developing peripheral nervous system, along with the pigmented cell (i.e. melanocyte) lineage." [MGI:anna] subset: efo_slim subset: uberon_slim subset: vertebrate_core synonym: "cephalic neural crest" EXACT [EMAPA:16091] synonym: "CNC" EXACT OMO:0003000 [XAO:0001001] synonym: "cranial NCC population" EXACT [] synonym: "crista neuralis cranialis" RELATED OMO:0003011 [Wikipedia:Cranial_neural_crest] synonym: "head crest" RELATED [] synonym: "head NCC population" EXACT [] synonym: "head neural crest" RELATED [] xref: AAO:0010580 xref: EFO:0003645 xref: EHDAA2:0004420 xref: EMAPA:16091 xref: TAO:0001194 xref: VHOG:0000063 xref: Wikipedia:Cranial_neural_crest xref: XAO:0001001 xref: ZFA:0001194 is_a: BFO:0000002 is_a: UBERON:0005291 ! embryonic tissue relationship: BFO:0000050 UBERON:0002342 ! part of neural crest relationship: BFO:0000051 CL:0000008 ! has part migratory cranial neural crest cell property_value: skos:prefLabel "cranial neural crest" xsd:string [Term] id: UBERON:0003100 name: female organism def: "Gonochoristic organism that can produce female gametes." [CARO:0000028] subset: pheno_slim subset: vertebrate_core synonym: "female" RELATED [TAO:0000303] synonym: "female human body" NARROW SENSU [FMA:67812] xref: AAO:0010030 xref: BILA:0000028 xref: CARO:0000028 xref: FBbt:00007011 {sssom:mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"} xref: FMA:67812 xref: HAO:0000028 xref: SCTID:362608006 xref: TAO:0000303 xref: TGMA:0001839 xref: XAO:0003005 xref: ZFA:0000303 is_a: UBERON:0000468 ! multicellular organism disjoint_from: UBERON:0003101 ! male organism property_value: skos:prefLabel "female organism" xsd:string [Term] id: UBERON:0003101 name: male organism def: "Gonochoristic organism that can produce male gametes." [CARO:0000027] subset: pheno_slim subset: vertebrate_core synonym: "male" RELATED [TAO:0000242] synonym: "male human body" NARROW SENSU [FMA:67811] xref: AAO:0010033 xref: BILA:0000027 xref: CARO:0000027 xref: FBbt:00007004 {sssom:mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"} xref: FMA:67811 xref: HAO:0000027 xref: SCTID:362609003 xref: TAO:0000242 xref: TGMA:0001838 xref: WBbt:0007850 xref: XAO:0003006 xref: ZFA:0000242 is_a: UBERON:0000468 ! multicellular organism [Term] id: UBERON:0003102 name: surface structure def: "Anatomical structure that overlaps the outer epithelial layer and is adjacent to the space surrounding the organism." [http://orcid.org/0000-0002-6601-2165, https://github.com/obophenotype/uberon/issues/24] subset: upper_level synonym: "anatomical surface feature" EXACT [EHDAA2:0003010] synonym: "surface feature" RELATED [] synonym: "surface region" RELATED [] synonym: "surface structures" RELATED OMO:0003004 [ZFA:0000292] xref: AAO:0010337 xref: AEO_RETIRED:0000010 xref: EHDAA2_RETIRED:0003010 xref: galen:SurfaceRegion xref: TAO:0000292 xref: VSAO:0000001 xref: Wikipedia:Surface_structure xref: XAO:0003028 xref: ZFA:0000292 is_a: UBERON:0000061 ! anatomical structure relationship: RO:0002220 UBERON:0013514 ! adjacent to space surrounding organism property_value: IAO:0000116 "consider obsoleting. See issue/1305" xsd:string property_value: skos:prefLabel "surface structure" xsd:string property_value: terms:contributor https://orcid.org/0000-0002-6601-2165 property_value: terms:contributor https://orcid.org/0000-0003-3162-7490 [Term] id: UBERON:0003103 name: compound organ def: "Anatomical structure that has as its parts two or more multi-tissue structures of at least two different types and which through specific morphogenetic processes forms a single distinct structural unit demarcated by bona fide boundaries from other distinct anatomical structures of different types." [CARO:0000024] subset: organ_slim subset: upper_level synonym: "organ" RELATED [] xref: AAO:0010015 xref: AEO:0000024 xref: BILA:0000024 xref: CARO:0000024 xref: EHDAA2:0003024 xref: HAO:0000024 xref: TADS:0000598 xref: TAO:0000496 xref: TGMA:0001837 xref: VHOG:0001723 xref: XAO:0003041 xref: ZFA:0000496 is_a: UBERON:0000062 ! organ property_value: skos:prefLabel "compound organ" xsd:string [Term] id: UBERON:0003104 name: mesenchyme def: "Portion of tissue composed of mesenchymal cells (motile cells that develop from epthelia via an epithelial to mesenchymal transition) and surrounding extracellular material. Mesenchyme has different embryological origins in different metazoan taxa - in many invertebrates it derives in whole or part from ectoderm. In vertebrates it derives largely from mesoderm, and sometimes the terms are used interchangeably, e.g. lateral plate mesoderm/mesenchyme." [https://archive.org/details/invertebratesnde00brus/page/n240/mode/2up, https://en.wikipedia.org/wiki/Mesenchyme, https://github.com/obophenotype/uberon/issues/1641] subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "mesenchyma" RELATED OMO:0003011 [Wikipedia:Mesenchyme] synonym: "mesenchymal tissue" EXACT [] synonym: "mesenchyme tissue" EXACT [] synonym: "portion of mesenchymal tissue" EXACT [] synonym: "portion of mesenchyme tissue" EXACT [] xref: AAO:0010427 xref: AEO:0000145 xref: BTO:0001393 xref: CALOHA:TS-0620 xref: EHDAA2:0003145 xref: EV:0100007 xref: NCIT:C13301 xref: TAO:0000393 xref: UMLS:C0162415 {source="ncithesaurus:Mesenchyme"} xref: VHOG:0000170 xref: Wikipedia:Mesenchyme xref: XAO:0003046 xref: ZFA:0000393 is_a: UBERON:0000479 ! tissue intersection_of: UBERON:0000479 ! tissue intersection_of: RO:0002473 CL:0008019 ! composed primarily of mesenchymal cell relationship: RO:0002328 GO:0032502 ! functionally related to developmental process relationship: RO:0002473 CL:0008019 ! composed primarily of mesenchymal cell property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/f/f4/Mesenchymal_Stem_Cell.jpg" xsd:anyURI property_value: IAO:0000116 "the relationship to mesoderm is weaker than develops_from in order to have classes such as 'head mesenchyme from mesoderm' make sense" xsd:string property_value: skos:prefLabel "mesenchyme" xsd:string [Term] id: UBERON:0003110 name: otic region synonym: "cranial vault" RELATED [ZFA:0000189] xref: AAO:0010208 xref: TAO:0000189 xref: XAO:0003175 xref: ZFA:0000189 is_a: UBERON:0034921 ! multi organ part structure relationship: BFO:0000050 UBERON:0001703 ! part of neurocranium relationship: BFO:0000050 UBERON:0002241 ! part of chondrocranium property_value: skos:prefLabel "otic region" xsd:string [Term] id: UBERON:0003111 name: sphenoid region def: "Anatomical cluster that forms the floor and sidewalls of the middle part of the cranium." [TAO:0000290, UBERONREF:0000007] xref: AAO:0010207 xref: TAO:0000290 xref: XAO:0003174 xref: ZFA:0000290 is_a: UBERON:0034921 ! multi organ part structure relationship: BFO:0000050 UBERON:0001703 ! part of neurocranium relationship: BFO:0000050 UBERON:0002241 ! part of chondrocranium property_value: skos:prefLabel "sphenoid region" xsd:string [Term] id: UBERON:0003112 name: olfactory region def: "Anatomical cluster that is located in the anterior region of the cranium and provides structural support for the olfactory organ." [TAO:0000351] subset: efo_slim synonym: "ethmoid region" RELATED [ZFA:0000351] xref: AAO:0010206 xref: EFO:0003525 xref: NCIT:C98765 xref: TAO:0000351 xref: XAO:0003172 xref: ZFA:0000351 is_a: UBERON:0034921 ! multi organ part structure relationship: BFO:0000050 UBERON:0001703 ! part of neurocranium relationship: BFO:0000050 UBERON:0002241 ! part of chondrocranium property_value: skos:prefLabel "olfactory region" xsd:string [Term] id: UBERON:0003113 name: dermatocranium def: "Subdivision of skeleton that includes all dermal bones in the cranial skeleton[ZFA,modified]." [Wikipedia:Skull_roof, ZFA:0000863] synonym: "dendrocranium" EXACT [TAO:0000863] synonym: "dermal bone cranium" RELATED [ZFA:0000863] synonym: "dermal part of skull" RELATED [] synonym: "dermal skull bones" RELATED [] synonym: "dermal skull roof" NARROW [PMID:11523816, Wikipedia:Skull_roof] synonym: "dermatocranial cover" NARROW [] synonym: "exocranium" EXACT [UBERONREF:0000007] synonym: "roof of skull" NARROW [Wikipedia:Skull_roof] synonym: "roofing bones of the skull" RELATED [Wikipedia:Skull_roof] synonym: "skull exoskeleton" RELATED [] synonym: "skull roof" NARROW [PMID:11523816, Wikipedia:Skull_roof] xref: AAO:0010154 xref: TAO:0000863 xref: VHOG:0001665 xref: Wikipedia:Skull_roof xref: XAO:0003169 xref: ZFA:0000863 is_a: UBERON:0011159 ! primary subdivision of cranial skeletal system relationship: BFO:0000050 UBERON:0010364 ! part of dermal skeleton property_value: IAO:0000116 "wikipedia treats skull roof and dermatocranium as synonymous, but some sources treat the roof as being part of the dermatocranium - see UBERONREF:0000007" xsd:string property_value: RO:0002161 NCBITaxon:7777 {source="ISBN:0073040584"} property_value: skos:prefLabel "dermatocranium" xsd:string [Term] id: UBERON:0003114 name: pharyngeal arch 3 def: "The third branchial arch contributes to the development of the hyoid bone, stylopharyngeus muscle, inferior parathyroid gland, and thymus." [MP:0006339] subset: pheno_slim subset: vertebrate_core synonym: "3rd arch" RELATED [EHDAA2:0000069] synonym: "3rd pharyngeal arch" EXACT [] synonym: "3rd visceral arch" RELATED [VHOG:0000298] synonym: "branchial arch 1" RELATED SENSU [AAO:0010365, ZFA:0001606] synonym: "first branchial arch" RELATED SENSU [ZFA:0001606] synonym: "first gill arch" EXACT SENSU [ZFA:0001606] synonym: "gill arch 1" EXACT SENSU [ZFA:0001606] synonym: "third pharyngeal arch" EXACT [] synonym: "third visceral arch" EXACT [] synonym: "visceral arch 3" EXACT [] xref: AAO:0010365 xref: EHDAA2:0000069 xref: EHDAA:1080 xref: EMAPA:16399 xref: FMA:293029 xref: SCTID:308769006 xref: TAO:0001598 xref: VHOG:0000298 xref: XAO:0000447 xref: ZFA:0001606 is_a: UBERON:0002539 ! pharyngeal arch property_value: skos:prefLabel "pharyngeal arch 3" xsd:string [Term] id: UBERON:0003115 name: pharyngeal arch 4 def: "Contributes to development of the cartilage of the larynx, laryngeal, pharyngeal, and soft palate muscles, superior parathyroid gland, and C-cells of the thymus." [MP:0006340] subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "4th arch" RELATED [EHDAA2:0000086] synonym: "4th branchial arch" EXACT SENSU [] synonym: "4th pharyngeal arch" EXACT [] synonym: "4th visceral arch" EXACT [] synonym: "branchial arch 2" RELATED SENSU [AAO:0010366, ZFA:0001607] synonym: "fourth pharyngeal arch" EXACT [] synonym: "fourth visceral arch" RELATED [VHOG:0000299] synonym: "gill arch 2" EXACT SENSU [ZFA:0001607] synonym: "second branchial arch" RELATED SENSU [ZFA:0001607] synonym: "second gill arch" EXACT SENSU [ZFA:0001607] synonym: "visceral arch 4" EXACT [] xref: AAO:0010366 xref: EHDAA2:0000086 xref: EHDAA:1663 xref: EMAPA:16760 xref: FMA:293035 xref: SCTID:308770007 xref: TAO:0001599 xref: VHOG:0000299 xref: XAO:0000449 xref: ZFA:0001607 is_a: UBERON:0002539 ! pharyngeal arch property_value: skos:prefLabel "pharyngeal arch 4" xsd:string [Term] id: UBERON:0003116 name: pharyngeal arch 5 synonym: "5th pharyngeal arch" RELATED [VHOG:0001204] synonym: "5th visceral arch" RELATED [VHOG:0001204] synonym: "branchial arch 3" RELATED SENSU [AAO:0010367, XAO:0000451, ZFA:0001608] synonym: "fifth pharyngeal arch" RELATED [VHOG:0001204] synonym: "fifth visceral arch" EXACT [XAO:0000451] synonym: "gill arch 3" EXACT [ZFA:0001608] synonym: "third branchial arch" RELATED SENSU [XAO:0000451] synonym: "visceral arch 5" EXACT [ZFA:0001608] xref: AAO:0010367 xref: FMA:293045 xref: SCTID:308771006 xref: TAO:0001600 xref: VHOG:0001204 xref: XAO:0000451 xref: ZFA:0001608 is_a: UBERON:0002539 ! pharyngeal arch [Term] id: UBERON:0003117 name: pharyngeal arch 6 def: "The 6th pharyngeal arch. contributes to the development of the sternocleidomastoid and trapezius muscles." [MP:0006347] subset: pheno_slim synonym: "6th arch" EXACT [EHDAA2:0004075] synonym: "6th pharyngeal arch" RELATED [VHOG:0001205] synonym: "6th visceral arch" RELATED [VHOG:0001205] synonym: "branchial arch 4" RELATED SENSU [AAO:0010368, ZFA:0001609] synonym: "fourth branchial arch" RELATED SENSU [] synonym: "gill arch 4" EXACT [ZFA:0001609] synonym: "sixth branchial arch" EXACT [] synonym: "sixth pharyngeal arch" RELATED [VHOG:0001205] synonym: "sixth visceral arch" RELATED [XAO:0000453] synonym: "visceral arch 6" EXACT [ZFA:0001609] xref: AAO:0010368 xref: EHDAA2:0004075 xref: EMAPA:32766 xref: FMA:293047 xref: SCTID:308772004 xref: TAO:0001601 xref: VHOG:0001205 xref: XAO:0000453 xref: ZFA:0001609 is_a: UBERON:0002539 ! pharyngeal arch property_value: skos:prefLabel "pharyngeal arch 6" xsd:string [Term] id: UBERON:0003118 name: pharyngeal arch artery 1 def: "The vessels formed within the first pair of branchial arches in embryogenesis." [MP:0010355] subset: pheno_slim subset: vertebrate_core synonym: "1st aortic arch artery" RELATED [EMAPA:16685] synonym: "1st arch artery" EXACT [EMAPA:16685] synonym: "1st branchial arch artery" RELATED [EMAPA:16685] synonym: "1st pharyngeal arch artery" RELATED [EMAPA:16685] synonym: "AA1" EXACT [ZFA:0005005] synonym: "aortic arch 1" EXACT [ZFA:0005005] synonym: "first aortic arch" EXACT [XAO:0000342] synonym: "first arch artery" RELATED [EMAPA:16685] synonym: "first branchial arch artery" EXACT [] synonym: "mandibular aortic arch" EXACT [ZFA:0005005] xref: AAO:0010415 xref: EHDAA2:0000007 xref: EMAPA:16202 xref: EMAPA:16685 xref: SCTID:308774003 xref: TAO:0005005 xref: VHOG:0000149 xref: XAO:0000342 xref: ZFA:0005005 is_a: UBERON:0004363 ! pharyngeal arch artery intersection_of: UBERON:0004363 ! pharyngeal arch artery intersection_of: BFO:0000050 UBERON:0004362 ! part of pharyngeal arch 1 relationship: BFO:0000050 UBERON:0004362 ! part of pharyngeal arch 1 relationship: RO:0002433 UBERON:0004362 ! contributes to morphology of pharyngeal arch 1 property_value: skos:prefLabel "pharyngeal arch artery 1" xsd:string [Term] id: UBERON:0003119 name: pharyngeal arch artery 2 def: "The vessels formed within the second pair of branchial arches in embryogenesis." [MP:0010356] subset: pheno_slim subset: vertebrate_core synonym: "2nd aortic arch artery" RELATED [EMAPA:16686] synonym: "2nd arch artery" EXACT [EHDAA2:0000051] synonym: "2nd branchial arch artery" RELATED [EMAPA:16686] synonym: "2nd pharyngeal arch artery" RELATED [EMAPA:16686] synonym: "AA2" EXACT [ZFA:0005006] synonym: "aortic arch 2" EXACT [ZFA:0005006] synonym: "hyoid aortic arch" EXACT [ZFA:0005006] synonym: "second aortic arch" EXACT [XAO:0000343] synonym: "second branchial arch artery" EXACT [] xref: AAO:0010418 xref: EHDAA2:0000051 xref: EMAPA:16203 xref: EMAPA:16686 xref: SCTID:308775002 xref: TAO:0005006 xref: VHOG:0000148 xref: Wikipedia:Aortic_arches#Arches_1_and_2 xref: XAO:0000343 xref: ZFA:0005006 is_a: UBERON:0004363 ! pharyngeal arch artery intersection_of: UBERON:0004363 ! pharyngeal arch artery intersection_of: BFO:0000050 UBERON:0003066 ! part of pharyngeal arch 2 relationship: BFO:0000050 UBERON:0003066 ! part of pharyngeal arch 2 relationship: RO:0002433 UBERON:0003066 ! contributes to morphology of pharyngeal arch 2 property_value: skos:prefLabel "pharyngeal arch artery 2" xsd:string [Term] id: UBERON:0003120 name: pharyngeal arch artery 3 def: "The vessels formed within the third pair of branchial arches in embryogenesis." [MP:0006356] subset: pheno_slim subset: vertebrate_core synonym: "3rd aortic arch artery" RELATED [EMAPA:16687] synonym: "3rd arch artery" EXACT [EHDAA2:0000070] synonym: "3rd branchial arch artery" RELATED [EMAPA:16687] synonym: "3rd pharyngeal arch artery" RELATED [EMAPA:16687] synonym: "AA3" EXACT [ZFA:0005007] synonym: "aortic arch 3" EXACT [ZFA:0005007] synonym: "carotid arch" EXACT [Wikipedia:Aortic_arches#Arch_3] synonym: "third aortic arch" EXACT [XAO:0000344] synonym: "third branchial arch artery" EXACT [] xref: AAO:0010419 xref: EHDAA2:0000070 xref: EMAPA:16687 xref: SCTID:308776001 xref: TAO:0005007 xref: VHOG:0000147 xref: Wikipedia:Aortic_arches#Arch_3 xref: XAO:0000344 xref: ZFA:0005007 is_a: UBERON:0004363 ! pharyngeal arch artery intersection_of: UBERON:0004363 ! pharyngeal arch artery intersection_of: BFO:0000050 UBERON:0003114 ! part of pharyngeal arch 3 relationship: BFO:0000050 UBERON:0003114 ! part of pharyngeal arch 3 relationship: RO:0002433 UBERON:0003114 ! contributes to morphology of pharyngeal arch 3 property_value: skos:prefLabel "pharyngeal arch artery 3" xsd:string [Term] id: UBERON:0003121 name: pharyngeal arch artery 4 def: "The vessels formed within the fourth pair of branchial arches in embryogenesis." [MP:0006354] comment: proximal right subclavian subset: pheno_slim subset: vertebrate_core synonym: "4th aortic arch artery" RELATED [EMAPA:17004] synonym: "4th arch artery" EXACT [EHDAA2:0000087] synonym: "4th branchial arch artery" RELATED [EMAPA:17004] synonym: "4th pharyngeal arch artery" RELATED [EMAPA:17004] synonym: "AA4" EXACT [ZFA:0005008] synonym: "aortic arch 4" EXACT [ZFA:0005008] synonym: "fourth aortic arch" EXACT [XAO:0000355] synonym: "fourth branchial arch artery" EXACT [] synonym: "systemic arch" RELATED [ISBN:0073040584, XAO:0000355] xref: AAO:0010420 xref: EHDAA2:0000087 xref: EMAPA:17004 xref: SCTID:308777005 xref: TAO:0005008 xref: Wikipedia:Aortic_arches#Arch_4 xref: XAO:0000355 xref: ZFA:0005008 is_a: UBERON:0004363 ! pharyngeal arch artery intersection_of: UBERON:0004363 ! pharyngeal arch artery intersection_of: BFO:0000050 UBERON:0003115 ! part of pharyngeal arch 4 relationship: BFO:0000050 UBERON:0003115 ! part of pharyngeal arch 4 property_value: skos:prefLabel "pharyngeal arch artery 4" xsd:string [Term] id: UBERON:0003122 name: pharyngeal arch artery 5 def: "The vessels formed within the fifth pair of pharyngeal arches in embryogenesis." [http://orcid.org/0000-0002-6601-2165] subset: vertebrate_core synonym: "AA5" EXACT [ZFA:0005009] synonym: "aortic arch 5" EXACT [ZFA:0005009] synonym: "fifth aortic arch" EXACT [XAO:0000352] xref: AAO:0010421 xref: SCTID:308778000 xref: TAO:0005009 xref: VHOG:0000145 xref: Wikipedia:Aortic_arches#Arch_5 xref: XAO:0000352 xref: ZFA:0005009 is_a: UBERON:0004363 ! pharyngeal arch artery intersection_of: UBERON:0004363 ! pharyngeal arch artery intersection_of: BFO:0000050 UBERON:0003116 ! part of pharyngeal arch 5 relationship: BFO:0000050 UBERON:0003116 ! part of pharyngeal arch 5 [Term] id: UBERON:0003123 name: pharyngeal arch artery 6 def: "The vessels formed within the sixth pair of branchial arches in embryogenesis." [MP:0006355] subset: pheno_slim subset: vertebrate_core synonym: "6th aortic arch artery" RELATED [EMAPA:17005] synonym: "6th arch artery" EXACT [EMAPA:17005] synonym: "6th branchial arch artery" RELATED [EMAPA:17005] synonym: "6th pharyngeal arch artery" RELATED [EMAPA:17005] synonym: "AA6" EXACT [ZFA:0005016] synonym: "aortic arch 6" EXACT [ZFA:0005016] synonym: "pulmonary arch" RELATED [ISBN:0073040584] synonym: "sixth aortic arch" EXACT [XAO:0000353] synonym: "sixth branchial arch artery" EXACT [] xref: AAO:0010422 xref: EHDAA2:0000102 xref: EMAPA:17005 xref: SCTID:308779008 xref: TAO:0005016 xref: VHOG:0000144 xref: Wikipedia:Aortic_arches#Arch_6 xref: XAO:0000353 xref: ZFA:0005016 is_a: UBERON:0004363 ! pharyngeal arch artery intersection_of: UBERON:0004363 ! pharyngeal arch artery intersection_of: BFO:0000050 UBERON:0003117 ! part of pharyngeal arch 6 relationship: BFO:0000050 UBERON:0003117 ! part of pharyngeal arch 6 property_value: skos:prefLabel "pharyngeal arch artery 6" xsd:string [Term] id: UBERON:0003124 name: chorion membrane def: "The outermost extraembryonic membrane of amniotes." [http://orcid.org/0000-0002-6601-2165, https://github.com/geneontology/go-ontology/issues/22603, MESH:A10.615.284.473, MP:0002836] comment: This term refers to the amniote structure. It is distinct from the concept of chorion in insects subset: efo_slim subset: human_reference_atlas subset: pheno_slim subset: uberon_slim synonym: "chorion" EXACT [] synonym: "chorion (vertebrates)" EXACT [] synonym: "chorion frondosum" RELATED [Wikipedia:Chorion] synonym: "chorionic sac" RELATED [Wikipedia:Chorion] synonym: "embryonic chorion" EXACT [] synonym: "fetal chorion" EXACT [] synonym: "uterine chorion" EXACT [http://orcid.org/0000-0002-6601-2165, ZFIN:curator] xref: BTO:0000252 xref: CALOHA:TS-0144 xref: EFO:0002780 xref: EHDAA2:0000245 xref: EHDAA:150 xref: EMAPA:16112 xref: EV:0100121 xref: FMA:80224 xref: GAID:1299 xref: MESH:D002823 xref: NCIT:C34122 xref: NCIT:C34124 xref: UMLS:C0008503 {source="ncithesaurus:Chorion"} xref: UMLS:C1516505 {source="ncithesaurus:Chorionic_Sac"} xref: VHOG:0000200 xref: Wikipedia:Chorion is_a: BFO:0000002 is_a: UBERON:0005631 ! extraembryonic membrane relationship: BFO:0000051 UBERON:0003265 ! has part chorionic mesenchyme relationship: BFO:0000051 UBERON:0003374 ! has part chorionic ectoderm relationship: RO:0002202 UBERON:0005971 {source="ISBN:0073040584"} ! develops from amniotic fold relationship: RO:0002220 UBERON:0000922 ! adjacent to embryo property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/5/51/Gray24.png" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0003126 name: trachea def: "The trachea is the portion of the airway that attaches to the bronchi as it branches [GO:dph]." [GO:0060438, Wikipedia:Vertebrate_trachea] subset: efo_slim subset: human_reference_atlas subset: major_organ subset: pheno_slim subset: uberon_slim synonym: "cartilaginous trachea" EXACT [] synonym: "tracheal tubule" RELATED [BTO:0001388] synonym: "vertebrate trachea" EXACT SENSU [] synonym: "windpipe" EXACT [] xref: AAO:0010140 xref: BTO:0001388 xref: CALOHA:TS-1060 xref: EFO:0000935 xref: EHDAA2:0002066 xref: EHDAA:3078 xref: EMAPA:16853 xref: EV:0100040 xref: FMA:7394 xref: GAID:361 xref: MA:0000441 xref: MAT:0000137 xref: MESH:D014132 xref: MIAA:0000137 xref: NCIT:C12428 xref: SCTID:181213009 xref: UMLS:C0040578 {source="ncithesaurus:Trachea"} xref: VHOG:0000371 xref: Wikipedia:Vertebrate_trachea xref: XAO:0000118 is_a: BFO:0000002 is_a: UBERON:0000117 ! respiratory tube relationship: BFO:0000050 UBERON:0007196 ! part of tracheobronchial tree relationship: RO:0001025 UBERON:0002224 ! located in thoracic cavity relationship: RO:0002202 UBERON:0008947 {source="EHDAA2"} ! develops from respiratory primordium relationship: RO:0002433 UBERON:0001004 ! contributes to morphology of respiratory system property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/9/9f/Illu_conducting_passages.svg" xsd:anyURI property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/c/c3/Illu_conducting_passages.jpg" xsd:anyURI property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/trachea-female/v1.1/assets/3d-vh-f-trachea.glb" xsd:anyURI property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/trachea-male/v1.1/assets/3d-vh-m-trachea.glb" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "trachea" xsd:string [Term] id: UBERON:0003127 name: open tracheal system trachea def: "A respiratory airway that is part of an open tracheal system." [http://orcid.org/0000-0002-6601-2165] subset: uberon_slim synonym: "invertebrate trachea" EXACT [] synonym: "trachea" BROAD SENSU [FBbt:00005043] xref: SPD:0000434 xref: TADS:0000315 xref: Wikipedia:Invertebrate_trachea is_a: UBERON:0001005 ! respiratory airway relationship: BFO:0000050 UBERON:0005155 ! part of open tracheal system relationship: BFO:0000051 UBERON:0003914 ! has part epithelial tube [Term] id: UBERON:0003128 name: cranium def: "Upper portion of the skull that excludes the mandible (when present in the organism)." [http://orcid.org/0000-0002-6601-2165, Wikipedia:Cranium_(anatomy)] subset: efo_slim subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "bones of cranium" EXACT [FMA:71325] synonym: "calvarium" RELATED [BTO:0001328] synonym: "epicranial plate" RELATED [] synonym: "ossa cranii" EXACT OMO:0003011 [FMA:71325, FMA:TA] synonym: "set of bones of cranium" EXACT [FMA:71325] synonym: "skeletal system of head" RELATED [] synonym: "skull minus mandible" EXACT [] synonym: "upper part of skull" EXACT [] xref: BTO:0001328 xref: EFO:0000831 xref: EHDAA:6029 xref: FMA:71325 xref: MA:0000316 xref: MAT:0000340 xref: MESH:D012886 {sssom:mapping_justification="https://w3id.org/semapv/vocab/LexicalMatching"} xref: MIAA:0000340 xref: SCTID:181889008 xref: VHOG:0000334 xref: Wikipedia:Cranium_(anatomy) is_a: UBERON:0000075 {source="FMA-inferred"} ! subdivision of skeletal system property_value: RO:0002175 NCBITaxon:7762 property_value: skos:prefLabel "cranium" xsd:string [Term] id: UBERON:0003129 name: skull def: "Anatomical structure that is part of the head consisting entirely of cranium and mandible[WP]." [http://sourceforge.net/tracker/?func=detail&aid=2962656&group_id=76834&atid=1205376, PMID:11523816, Wikipedia:Skull] subset: pheno_slim subset: uberon_slim synonym: "cranial skeleton" RELATED [] synonym: "skeletal system of head" RELATED [] xref: BTO:0001295 xref: CALOHA:TS-2344 xref: EHDAA2:0000325 xref: EMAPA:17680 xref: FMA:46565 xref: GAID:82 xref: galen:Skull xref: MESH:D012886 xref: NCIT:C12789 xref: SCTID:110530005 xref: UMLS:C0037303 {source="ncithesaurus:Skull"} xref: Wikipedia:Skull xref: WikipediaCategory:Skull is_a: UBERON:0000075 {source="FMA"} ! subdivision of skeletal system relationship: BFO:0000050 UBERON:0000033 ! part of head relationship: BFO:0000050 UBERON:0010323 ! part of cranial skeletal system relationship: BFO:0000051 UBERON:0003128 ! has part cranium relationship: BFO:0000051 UBERON:0003278 ! has part skeleton of lower jaw property_value: skos:prefLabel "skull" xsd:string [Term] id: UBERON:0003133 name: reproductive organ def: "An organ involved in reproduction." [UBERON:xp] subset: functional_classification subset: organ_slim subset: pheno_slim synonym: "genital organ" EXACT [] synonym: "genitalia" RELATED OMO:0003004 [] synonym: "reproductive system organ" EXACT [] synonym: "sex organ" EXACT [] xref: EMAPA:37731 {source="MA:th"} xref: MA:0001752 xref: MESH:D005835 xref: NCIT:C25177 xref: SCTID:128181006 xref: TGMA:0000591 xref: UMLS:C0017420 {source="ncithesaurus:Genitalia"} xref: WBbt:0008422 is_a: UBERON:0000062 ! organ is_a: UBERON:0005156 ! reproductive structure intersection_of: UBERON:0000062 ! organ intersection_of: RO:0002216 GO:0022414 ! capable of part of reproductive process relationship: RO:0002216 GO:0022414 ! capable of part of reproductive process property_value: skos:prefLabel "reproductive organ" xsd:string [Term] id: UBERON:0003134 name: female reproductive organ def: "A female organ involved in reproduction." [UBERON:xp] subset: organ_slim subset: pheno_slim synonym: "female organism reproductive organ" EXACT [OBOL:automatic] synonym: "female organism reproductive structure" EXACT [OBOL:automatic] synonym: "female organism reproductive system organ" EXACT [OBOL:automatic] synonym: "female organism sex organ" EXACT [OBOL:automatic] synonym: "female reproductive gland/organ" EXACT [MA:0000544] synonym: "female reproductive system organ" EXACT [] synonym: "female sex organ" EXACT [] synonym: "reproductive organ of female organism" EXACT [OBOL:automatic] synonym: "reproductive structure of female organism" EXACT [OBOL:automatic] synonym: "reproductive system organ of female organism" EXACT [OBOL:automatic] synonym: "sex organ of female organism" EXACT [OBOL:automatic] xref: EMAPA:28540 xref: MA:0000544 is_a: UBERON:0003133 ! reproductive organ intersection_of: UBERON:0003133 ! reproductive organ intersection_of: BFO:0000050 UBERON:0003100 ! part of female organism relationship: BFO:0000050 UBERON:0000474 ! part of female reproductive system property_value: skos:prefLabel "female reproductive organ" xsd:string [Term] id: UBERON:0003135 name: male reproductive organ def: "A male organ involved in reproduction." [UBERON:xp] subset: organ_slim subset: pheno_slim synonym: "male genital" RELATED [WBbt:0008423] synonym: "male organism reproductive organ" EXACT [OBOL:automatic] synonym: "male organism reproductive structure" EXACT [OBOL:automatic] synonym: "male organism reproductive system organ" EXACT [OBOL:automatic] synonym: "male organism sex organ" EXACT [OBOL:automatic] synonym: "male reproductive gland/organ" EXACT [MA:0000545] synonym: "male reproductive system organ" EXACT [] synonym: "male sex organ" EXACT [] synonym: "reproductive organ of male organism" EXACT [OBOL:automatic] synonym: "reproductive structure of male organism" EXACT [OBOL:automatic] synonym: "reproductive system organ of male organism" EXACT [OBOL:automatic] synonym: "sex organ of male organism" EXACT [OBOL:automatic] xref: MA:0000545 xref: WBbt:0008423 is_a: UBERON:0003133 ! reproductive organ intersection_of: UBERON:0003133 ! reproductive organ intersection_of: BFO:0000050 UBERON:0003101 ! part of male organism relationship: BFO:0000050 UBERON:0000079 ! part of male reproductive system [Term] id: UBERON:0003209 name: blood nerve barrier def: "Barrier between the perineurium of peripheral nerves and the vascular endothelium of endoneurial capillaries. The perineurium acts as a diffusion barrier, but ion permeability at the blood-nerve barrier is still higher than at the blood-brain barrier[GO]." [GO:0008065, Wikipedia:Blood-nerve_barrier] synonym: "blood-nerve barrier" EXACT [] xref: Wikipedia:Blood-nerve_barrier is_a: UBERON:0000119 ! cell layer relationship: BFO:0000050 UBERON:0001016 ! part of nervous system relationship: RO:0002162 NCBITaxon:7711 ! in taxon Chordata relationship: RO:0002220 UBERON:0000179 ! adjacent to haemolymphatic fluid relationship: RO:0002220 UBERON:0001021 ! adjacent to nerve [Term] id: UBERON:0003210 name: blood-cerebrospinal fluid barrier def: "Barrier in the choroid plexus located in the lateral, third, and fourth brain ventricles that controls the entrance of substances into the cerebrospinal fluid from the blood[MP]." [MP:0006088] subset: pheno_slim synonym: "blood-CSF barrier" EXACT [MP:0006088] is_a: UBERON:0000119 ! cell layer relationship: BFO:0000050 UBERON:0001886 ! part of choroid plexus relationship: RO:0002220 UBERON:0000178 ! adjacent to blood relationship: RO:0002220 UBERON:0001359 ! adjacent to cerebrospinal fluid [Term] id: UBERON:0003212 name: gustatory organ def: "Any sense organ that functions in (some) detection of chemical stimulus involved in sensory perception of taste (GO:0050912)." [FBC:auto_generated_definition] synonym: "gustatory organ system organ" EXACT [OBOL:automatic] synonym: "gustatory system organ" EXACT [OBOL:automatic] synonym: "organ of gustatory organ system" EXACT [OBOL:automatic] synonym: "organ of gustatory system" EXACT [OBOL:automatic] synonym: "organ of taste system" EXACT [OBOL:automatic] synonym: "taste organ" EXACT [] synonym: "taste system organ" EXACT [OBOL:automatic] xref: FBbt:00005159 {sssom:mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"} xref: FMA:77853 is_a: UBERON:0000005 ! chemosensory organ intersection_of: UBERON:0000062 ! organ intersection_of: RO:0002216 GO:0050912 ! capable of part of detection of chemical stimulus involved in sensory perception of taste relationship: BFO:0000050 UBERON:0001033 ! part of gustatory system relationship: RO:0002216 GO:0050912 ! capable of part of detection of chemical stimulus involved in sensory perception of taste property_value: skos:prefLabel "gustatory organ" xsd:string [Term] id: UBERON:0003214 name: mammary gland alveolus def: "A sac-like structure that is found in the mature gland[GO]." [GO:0060749] subset: pheno_slim synonym: "alveolus of lactiferous gland" EXACT [OBOL:automatic] synonym: "alveolus of lobe of breast" EXACT [OBOL:automatic] synonym: "alveolus of lobe of mammary gland" EXACT [OBOL:automatic] synonym: "alveolus of mammary gland" EXACT [OBOL:automatic] synonym: "lactiferous alveolus" EXACT [] synonym: "lactiferous gland alveolus" EXACT [] synonym: "lobe of breast alveolus" EXACT [OBOL:automatic] synonym: "lobe of mammary gland alveolus" EXACT [OBOL:automatic] synonym: "mammary alveoli" RELATED OMO:0003004 [] synonym: "mammary alveolus" EXACT [] xref: EMAPA:36566 xref: FMA:73285 xref: MA:0002760 is_a: UBERON:0003215 ! alveolus intersection_of: UBERON:0003215 ! alveolus intersection_of: BFO:0000050 UBERON:0001911 ! part of mammary gland relationship: BFO:0000050 UBERON:0001912 ! part of lobule of mammary gland relationship: RO:0002433 UBERON:0001912 ! contributes to morphology of lobule of mammary gland [Term] id: UBERON:0003215 name: alveolus def: "Organ part that has the form of a hollow cavity[WP]." [Wikipedia:Alveolus] subset: efo_slim xref: EFO:0002513 xref: FMA:82493 xref: NCIT:C12986 xref: UMLS:C0034051 {source="ncithesaurus:Alveolus"} xref: Wikipedia:Alveolus is_a: UBERON:0000064 ! organ part [Term] id: UBERON:0003218 name: ovary septum def: "Septum that divides the ovary, the basal portion of a carpel or group of fused carpels, that encloses the ovule(s)[GO]." [GO:0080126] is_a: UBERON:0003037 ! septum intersection_of: UBERON:0003037 ! septum intersection_of: BFO:0000050 UBERON:0000992 ! part of ovary relationship: BFO:0000050 UBERON:0000992 ! part of ovary property_value: skos:prefLabel "ovary septum" xsd:string [Term] id: UBERON:0003220 name: metanephric mesenchyme def: "One of the two embryological structures that give rise to the kidney (the other is the ureteric bud). The metanephric blastema mostly develops into nephrons, but can also form parts of the collecting duct system.[WP]. Metanephric mesenchyme is the tissue made up of loosely connected mesenchymal cells in the metanephros[GO]." [GO:0072075, Wikipedia:Metanephric_blastema] comment: Genes: The positional specification of the metanephrogenic mesenchyme is negatively regulated by Foxc1 and Foxc2. Next the permanent kidney forming metanephrogenic mesenchyme is specified by Hox11 genes. The competence to respond to ureteric bud inducers is regulated by WT1. GDNF secretion restricted to posterior region by Robo2 and Sprouty1. The receptors for GDNF are synthesized in the nephric ducts and later in ureteric buds [ISBN:9780878932504 "Developmental Biology"] subset: pheno_slim synonym: "metanephric blastema" EXACT [Wikipedia:Metanephric_blastema] synonym: "metanephric mesoderm" EXACT [Wikipedia:Metanephric_blastema] synonym: "metanephrogenic mesenchyme" EXACT [EHDAA:5021] synonym: "metanephros associated mesenchyme" EXACT [RETIRED_EHDAA2:0001139] xref: EHDAA2:0004062 xref: EHDAA:4041 xref: EHDAA:5021 xref: EHDAA:5915 xref: EMAPA:17375 xref: SCTID:361529008 xref: VHOG:0000540 xref: Wikipedia:Metanephric_blastema is_a: UBERON:0003918 ! kidney mesenchyme is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0005291 ! embryonic tissue is_a: UBERON:0006598 ! presumptive structure intersection_of: UBERON:0003104 ! mesenchyme intersection_of: RO:0002387 UBERON:0000081 ! has potential to develop into metanephros relationship: RO:0002202 UBERON:0003074 ! develops from mesonephric duct relationship: RO:0002256 UBERON:0000084 {source="ISBN:9780878932504"} ! developmentally induced by ureteric bud relationship: RO:0002387 UBERON:0000081 ! has potential to develop into metanephros [Term] id: UBERON:0003221 name: phalanx def: "Endochondral bones that are often elongate and arranged in rows of articulating elements, and form the visible part of the digits." [VSAO:0000199, Wikipedia:Phalanx_bones] subset: pheno_slim synonym: "digit long bone" EXACT [OBOL:automatic] synonym: "long bone of digit" EXACT [OBOL:automatic] synonym: "phalange" EXACT [] synonym: "phalanges" EXACT OMO:0003004 [] synonym: "phalanx bone" EXACT [Wikipedia:Phalanx_bones] xref: CALOHA:TS-2211 xref: EMAPA:32614 xref: FMA:321661 xref: galen:Phalanx xref: MA:0000304 xref: NCIT:C33317 xref: SCTID:290029003 xref: UMLS:C0222682 {source="ncithesaurus:Phalanx"} xref: VSAO:0000199 xref: Wikipedia:Phalanx_bones is_a: UBERON:0003606 ! limb long bone is_a: UBERON:0012357 ! digitopodium bone is_a: UBERON:0015023 ! phalanx endochondral element intersection_of: UBERON:0015023 ! phalanx endochondral element intersection_of: RO:0002473 UBERON:0002481 ! composed primarily of bone tissue relationship: BFO:0000050 UBERON:5102544 ! part of individual digit of digitopodial skeleton relationship: RO:0002202 UBERON:0010701 ! develops from phalanx cartilage element [Term] id: UBERON:0003224 name: chorion syncytiotrophoblast def: "An extraembryonic structure that develops_from a syncytiotrophoblast and is part of a chorion." [OBOL:automatic] xref: EHDAA2:0001973 xref: EHDAA:156 is_a: BFO:0000002 is_a: UBERON:0000478 ! extraembryonic structure intersection_of: UBERON:0000478 ! extraembryonic structure intersection_of: BFO:0000050 UBERON:0003124 ! part of chorion membrane intersection_of: RO:0002202 UBERON:0000371 ! develops from syncytiotrophoblast relationship: BFO:0000050 UBERON:0003124 {source="EHDAA2"} ! part of chorion membrane relationship: RO:0002202 UBERON:0000371 ! develops from syncytiotrophoblast property_value: IAO:0000116 "TODO - check" xsd:string [Term] id: UBERON:0003229 name: epithelium of elbow def: "An epithelium that is part of a elbow [Automatically generated definition]." [OBOL:automatic] synonym: "cubital region epithelial tissue" EXACT [OBOL:automatic] synonym: "cubital region epithelium" EXACT [OBOL:automatic] synonym: "elbow epithelial tissue" EXACT [OBOL:automatic] synonym: "elbow epithelium" EXACT [OBOL:automatic] synonym: "epithelial tissue of cubital region" EXACT [OBOL:automatic] synonym: "epithelial tissue of elbow" EXACT [OBOL:automatic] synonym: "epithelium of cubital region" EXACT [OBOL:automatic] xref: EHDAA2:0000430 xref: EHDAA:4168 xref: EHDAA:6214 xref: EMAPA:17415 xref: VHOG:0001044 is_a: BFO:0000002 is_a: UBERON:0000483 ! epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: BFO:0000050 UBERON:0001461 ! part of elbow relationship: BFO:0000050 UBERON:0001461 ! part of elbow relationship: RO:0002202 UBERON:0003372 {source="EHDAA2"} ! develops from pectoral appendage bud ectoderm [Term] id: UBERON:0003230 name: epithelium of carpal region def: "An epithelium that is part of a wrist [Automatically generated definition]." [OBOL:automatic] synonym: "carpal region epithelial tissue" EXACT [OBOL:automatic] synonym: "carpal region epithelium" EXACT [OBOL:automatic] synonym: "epithelial tissue of carpal region" EXACT [OBOL:automatic] synonym: "epithelial tissue of wrist" EXACT [OBOL:automatic] synonym: "epithelium of wrist" EXACT [OBOL:automatic] synonym: "wrist epithelial tissue" EXACT [OBOL:automatic] synonym: "wrist epithelium" EXACT [OBOL:automatic] xref: EHDAA2:0000219 xref: EHDAA:5198 is_a: BFO:0000002 is_a: UBERON:0000490 {source="EHDAA2"} ! unilaminar epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: BFO:0000050 UBERON:0004452 ! part of carpal region relationship: BFO:0000050 UBERON:0004452 ! part of carpal region relationship: RO:0002202 UBERON:0003372 {source="EHDAA2"} ! develops from pectoral appendage bud ectoderm [Term] id: UBERON:0003231 name: epithelium of hip def: "An epithelium that is part of a hip [Automatically generated definition]." [OBOL:automatic] synonym: "epithelial tissue of hip" EXACT [OBOL:automatic] synonym: "epithelial tissue of hip region" EXACT [OBOL:automatic] synonym: "epithelial tissue of regio coxae" EXACT [OBOL:automatic] synonym: "epithelium of hip region" EXACT [OBOL:automatic] synonym: "epithelium of regio coxae" EXACT [OBOL:automatic] synonym: "hip epithelial tissue" EXACT [OBOL:automatic] synonym: "hip epithelium" EXACT [OBOL:automatic] synonym: "hip region epithelial tissue" EXACT [OBOL:automatic] synonym: "hip region epithelium" EXACT [OBOL:automatic] synonym: "regio coxae epithelial tissue" EXACT [OBOL:automatic] synonym: "regio coxae epithelium" EXACT [OBOL:automatic] xref: EHDAA2:0000784 xref: EHDAA:5155 xref: EHDAA:6180 xref: EMAPA:17491 xref: VHOG:0000779 is_a: BFO:0000002 is_a: UBERON:0000483 ! epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: BFO:0000050 UBERON:0001464 ! part of hip relationship: BFO:0000050 UBERON:0001464 ! part of hip relationship: RO:0002202 UBERON:0003371 {source="EHDAA2"} ! develops from pelvic appendage bud ectoderm [Term] id: UBERON:0003232 name: epithelium of knee def: "An epithelium that is part of a knee [Automatically generated definition]." [OBOL:automatic] synonym: "epithelial tissue of knee" EXACT [OBOL:automatic] synonym: "knee epithelial tissue" EXACT [OBOL:automatic] synonym: "knee epithelium" EXACT [OBOL:automatic] xref: EHDAA2:0000896 xref: EHDAA:5161 xref: EHDAA:6186 xref: EMAPA:17494 xref: VHOG:0000810 is_a: BFO:0000002 is_a: UBERON:0000483 ! epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: BFO:0000050 UBERON:0001465 ! part of knee relationship: BFO:0000050 UBERON:0001465 ! part of knee relationship: RO:0002202 UBERON:0003371 {source="EHDAA2"} ! develops from pelvic appendage bud ectoderm [Term] id: UBERON:0003233 name: epithelium of shoulder def: "An epithelium that is part of a shoulder [Automatically generated definition]." [OBOL:automatic] synonym: "epithelial tissue of shoulder" EXACT [OBOL:automatic] synonym: "shoulder epithelial tissue" EXACT [OBOL:automatic] synonym: "shoulder epithelium" EXACT [OBOL:automatic] xref: EHDAA2:0001835 xref: EHDAA:4182 xref: EHDAA:6230 xref: EMAPA:17422 xref: VHOG:0000761 is_a: BFO:0000002 is_a: UBERON:0000483 ! epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: BFO:0000050 UBERON:0001467 ! part of shoulder relationship: BFO:0000050 UBERON:0001467 ! part of shoulder relationship: RO:0002202 UBERON:0003372 {source="EHDAA2"} ! develops from pectoral appendage bud ectoderm [Term] id: UBERON:0003235 name: epithelium of upper jaw def: "An epithelium that is part of a upper jaw [Automatically generated definition]." [OBOL:automatic] synonym: "epithelial tissue of palatoquadrate arch" EXACT [OBOL:automatic] synonym: "epithelial tissue of upper jaw" EXACT [OBOL:automatic] synonym: "epithelium of palatoquadrate arch" EXACT [OBOL:automatic] synonym: "palatoquadrate arch epithelial tissue" EXACT [OBOL:automatic] synonym: "palatoquadrate arch epithelium" EXACT [OBOL:automatic] synonym: "upper jaw epithelial tissue" EXACT [OBOL:automatic] synonym: "upper jaw epithelium" EXACT [OBOL:automatic] xref: EHDAA2:0002119 xref: EHDAA:8027 xref: EMAPA:18971 is_a: UBERON:0035037 ! jaw epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: BFO:0000050 UBERON:0001709 ! part of upper jaw region relationship: BFO:0000050 UBERON:0001709 ! part of upper jaw region property_value: skos:prefLabel "epithelium of upper jaw" xsd:string [Term] id: UBERON:0003236 name: epithelium of lower jaw def: "An epithelium that is part of a lower jaw [Automatically generated definition]." [OBOL:automatic] synonym: "epithelial tissue of lower jaw" EXACT [OBOL:automatic] synonym: "epithelial tissue of ventral mandibular arch" EXACT [OBOL:automatic] synonym: "epithelium of ventral mandibular arch" EXACT [OBOL:automatic] synonym: "lower jaw epithelial tissue" EXACT [OBOL:automatic] synonym: "lower jaw epithelium" EXACT [OBOL:automatic] synonym: "ventral mandibular arch epithelial tissue" EXACT [OBOL:automatic] synonym: "ventral mandibular arch epithelium" EXACT [OBOL:automatic] xref: EHDAA2:0001019 xref: EHDAA:7999 xref: EMAPA:35516 xref: VHOG:0000802 is_a: UBERON:0035037 ! jaw epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: BFO:0000050 UBERON:0001710 ! part of lower jaw region relationship: BFO:0000050 UBERON:0001710 ! part of lower jaw region property_value: skos:prefLabel "epithelium of lower jaw" xsd:string [Term] id: UBERON:0003241 name: epithelium of utricle def: "An epithelium that is part of a utricle of membranous labyrinth [Automatically generated definition]." [OBOL:automatic] synonym: "epithelial tissue of membranous labyrinth utricle" EXACT [OBOL:automatic] synonym: "epithelial tissue of utricle" EXACT [OBOL:automatic] synonym: "epithelial tissue of utricle of membranous labyrinth" EXACT [OBOL:automatic] synonym: "epithelial tissue of utriculus (labyrinthus vestibularis)" EXACT [OBOL:automatic] synonym: "epithelium of macula of utricle of membranous labyrinth" NARROW [FMA:75604] synonym: "epithelium of membranous labyrinth utricle" EXACT [OBOL:automatic] synonym: "epithelium of utricle of membranous labyrinth" EXACT [OBOL:automatic] synonym: "epithelium of utriculus (labyrinthus vestibularis)" EXACT [OBOL:automatic] synonym: "membranous labyrinth utricle epithelial tissue" EXACT [OBOL:automatic] synonym: "membranous labyrinth utricle epithelium" EXACT [OBOL:automatic] synonym: "utricle epithelial tissue" EXACT [OBOL:automatic] synonym: "utricle epithelium" EXACT [OBOL:automatic] synonym: "utricle of membranous labyrinth epithelial tissue" EXACT [OBOL:automatic] synonym: "utricle of membranous labyrinth epithelium" EXACT [OBOL:automatic] synonym: "utriculus (labyrinthus vestibularis) epithelial tissue" EXACT [OBOL:automatic] synonym: "utriculus (labyrinthus vestibularis) epithelium" EXACT [OBOL:automatic] xref: EHDAA:4730 xref: EMAPA:17295 xref: FMA:75604 xref: MA:0001204 xref: RETIRED_EHDAA2:0002155 xref: VHOG:0000634 is_a: BFO:0000002 is_a: UBERON:0006932 {source="FMA"} ! vestibular epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: BFO:0000050 UBERON:0001853 ! part of utricle of membranous labyrinth relationship: BFO:0000050 UBERON:0002214 {source="FMA"} ! part of macula of utricle of membranous labyrinth relationship: BFO:0000051 CL:0002316 {source="FMA"} ! has part supporting cell of vestibular epithelium relationship: BFO:0000051 CL:1000379 {source="FMA"} ! has part type 1 vestibular sensory cell of epithelium of macula of utricle of membranous labyrinth relationship: BFO:0000051 CL:1000383 {source="FMA"} ! has part type 2 vestibular sensory cell of epithelium of macula of utricle of membranous labyrinth property_value: IAO:0000116 "TODO - check relationships w.r.t macula" xsd:string [Term] id: UBERON:0003242 name: epithelium of saccule def: "An epithelium that is part of a saccule of membranous labyrinth [Automatically generated definition]." [OBOL:automatic] synonym: "epithelial tissue of membranous labyrinth saccule" EXACT [OBOL:automatic] synonym: "epithelial tissue of saccule" EXACT [OBOL:automatic] synonym: "epithelial tissue of saccule of membranous labyrinth" EXACT [OBOL:automatic] synonym: "epithelial tissue of sacculus (labyrinthus vestibularis)" EXACT [OBOL:automatic] synonym: "epithelium of macula of saccule of membranous labyrinth" RELATED [FMA:75605] synonym: "epithelium of membranous labyrinth saccule" EXACT [OBOL:automatic] synonym: "epithelium of saccule of membranous labyrinth" EXACT [OBOL:automatic] synonym: "epithelium of sacculus (labyrinthus vestibularis)" EXACT [OBOL:automatic] synonym: "membranous labyrinth saccule epithelial tissue" EXACT [OBOL:automatic] synonym: "membranous labyrinth saccule epithelium" EXACT [OBOL:automatic] synonym: "saccule epithelial tissue" EXACT [OBOL:automatic] synonym: "saccule epithelium" EXACT [OBOL:automatic] synonym: "saccule of membranous labyrinth epithelial tissue" EXACT [OBOL:automatic] synonym: "saccule of membranous labyrinth epithelium" EXACT [OBOL:automatic] synonym: "sacculus (labyrinthus vestibularis) epithelial tissue" EXACT [OBOL:automatic] synonym: "sacculus (labyrinthus vestibularis) epithelium" EXACT [OBOL:automatic] xref: EHDAA:4724 xref: EMAPA:17292 xref: FMA:75605 xref: MA:0001202 xref: RETIRED_EHDAA2:0001771 xref: VHOG:0000633 is_a: BFO:0000002 is_a: UBERON:0006932 ! vestibular epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: BFO:0000050 UBERON:0001854 ! part of saccule of membranous labyrinth relationship: BFO:0000050 UBERON:0001854 ! part of saccule of membranous labyrinth relationship: BFO:0000051 CL:0002316 {source="FMA"} ! has part supporting cell of vestibular epithelium relationship: BFO:0000051 CL:1000380 {source="FMA"} ! has part type 1 vestibular sensory cell of epithelium of macula of saccule of membranous labyrinth relationship: BFO:0000051 CL:1000384 {source="FMA"} ! has part type 2 vestibular sensory cell of epithelium of macula of saccule of membranous labyrinth property_value: IAO:0000116 "TODO - check relationships w.r.t macula" xsd:string [Term] id: UBERON:0003243 name: epithelium of cochlear duct def: "An epithelium that is part of a cochlear duct of membranous labyrinth [Automatically generated definition]." [OBOL:automatic] synonym: "cochlear duct epithelial tissue" EXACT [OBOL:automatic] synonym: "cochlear duct epithelium" EXACT [OBOL:automatic] synonym: "cochlear duct of membranous labyrinth epithelial tissue" EXACT [OBOL:automatic] synonym: "cochlear duct of membranous labyrinth epithelium" EXACT [OBOL:automatic] synonym: "epithelial tissue of cochlear duct" EXACT [OBOL:automatic] synonym: "epithelial tissue of cochlear duct of membranous labyrinth" EXACT [OBOL:automatic] synonym: "epithelial tissue of Reissner's canal" EXACT [OBOL:automatic] synonym: "epithelium of cochlear duct of membranous labyrinth" EXACT [OBOL:automatic] synonym: "epithelium of Reissner's canal" EXACT [OBOL:automatic] synonym: "Reissner's canal epithelial tissue" EXACT [OBOL:automatic] synonym: "Reissner's canal epithelium" EXACT [OBOL:automatic] xref: EHDAA:4722 xref: EMAPA:17600 xref: RETIRED_EHDAA2:0000264 xref: VHOG:0000640 is_a: UBERON:0006937 ! inner ear epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: BFO:0000050 UBERON:0001855 ! part of cochlear duct of membranous labyrinth relationship: BFO:0000050 UBERON:0001855 ! part of cochlear duct of membranous labyrinth [Term] id: UBERON:0003244 name: epithelium of mammary gland def: "The epithelial layer of the luminal surfaces of the mammary gland." [MGI:csmith, MP:0009504] subset: pheno_slim synonym: "epithelium of lactiferous gland" EXACT [FMA:74445] synonym: "lactiferous gland epithelium" EXACT [FMA:74445] synonym: "mammary epithelium" EXACT [BTO:0001430] synonym: "mammary gland epithelial tissue" EXACT [OBOL:automatic] synonym: "mammary gland epithelium" EXACT [OBOL:automatic] xref: BTO:0001430 xref: CALOHA:TS-0593 xref: EHDAA2:0001057 xref: EHDAA:6526 xref: EMAPA:17760 xref: FMA:74445 xref: MA:0000792 xref: NCIT:C12937 xref: UMLS:C0596882 {source="ncithesaurus:Mammary_Epithelium"} xref: VHOG:0001088 is_a: BFO:0000002 is_a: UBERON:0000483 ! epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: BFO:0000050 UBERON:0001911 ! part of mammary gland relationship: BFO:0000050 UBERON:0001911 ! part of mammary gland relationship: RO:0002202 UBERON:0011272 {source="EHDAA2", source="Wikipathways:WP2062"} ! develops from embryonic skin basal layer relationship: RO:0002433 UBERON:0001911 ! contributes to morphology of mammary gland [Term] id: UBERON:0003247 name: epithelium of forearm def: "An epithelium that is part of a lower arm [Automatically generated definition]." [OBOL:automatic] synonym: "forearm epithelium" EXACT [] xref: EHDAA2:0000554 xref: EHDAA:4174 xref: EHDAA:6220 xref: EMAPA:17418 xref: VHOG:0001096 is_a: BFO:0000002 is_a: UBERON:0000483 ! epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: BFO:0000050 UBERON:0002386 ! part of forelimb zeugopod relationship: BFO:0000050 UBERON:0002386 ! part of forelimb zeugopod relationship: RO:0002202 UBERON:0003372 {source="EHDAA2"} ! develops from pectoral appendage bud ectoderm [Term] id: UBERON:0003248 name: epithelium of footplate def: "An epithelium that is part of a footplate." [OBOL:automatic] synonym: "foot plate epithelium" EXACT [] synonym: "footplate epithelium" EXACT [EHDAA2:0000548] xref: EHDAA2:0000548 xref: EHDAA:5145 xref: EHDAA:6144 xref: EMAPA:32655 is_a: BFO:0000002 is_a: UBERON:0000490 {source="EHDAA2"} ! unilaminar epithelium is_a: UBERON:0005291 ! embryonic tissue intersection_of: UBERON:0000483 ! epithelium intersection_of: BFO:0000050 UBERON:0006871 ! part of embryonic footplate relationship: BFO:0000050 UBERON:0006871 ! part of embryonic footplate relationship: RO:0002202 UBERON:0003372 {source="EHDAA2"} ! develops from pectoral appendage bud ectoderm [Term] id: UBERON:0003249 name: epithelium of otic placode def: "An epithelium that is part of a otic placode [Automatically generated definition]." [OBOL:automatic] synonym: "epithelial tissue of otic placode" EXACT [OBOL:automatic] synonym: "otic epithelium" EXACT [https://orcid.org/0000-0002-6601-2165] synonym: "otic placode epithelial tissue" EXACT [OBOL:automatic] synonym: "otic placode epithelium" EXACT [OBOL:automatic] xref: EHDAA2:0001341 xref: EHDAA:510 xref: EMAPA:16197 xref: VHOG:0000636 xref: ZFA:0007068 is_a: UBERON:0005291 ! embryonic tissue is_a: UBERON:0015807 ! ear epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: BFO:0000050 UBERON:0003069 ! part of otic placode relationship: BFO:0000050 UBERON:0003069 ! part of otic placode property_value: IAO:0000116 "check ZFA, placemeant, appears to refer to both adult structures and primordium" xsd:string property_value: skos:prefLabel "epithelium of otic placode" xsd:string [Term] id: UBERON:0003252 name: thoracic rib cage def: "Subdivision of skeletal system that consists of all ribs in an organism connected to the sternum and the vertebrae. Some vertebrates have abdominal ribs (gastrialia), not connected to the vertebrate - these are not considered part of the rib case." [https://orcid.org/0000-0002-6601-2165] subset: pheno_slim synonym: "cavea thoracis" EXACT OMO:0003011 [FMA:7480, FMA:TA] synonym: "cavea thoracis" RELATED OMO:0003011 [Wikipedia:Human_rib_cage] synonym: "rib cage" EXACT [FMA:7480] synonym: "thoracic cage" EXACT [FMA:7480] xref: FMA:7480 xref: galen:RibCage xref: SCTID:361741004 xref: Wikipedia:Human_rib_cage xref: Wikipedia:Rib_cage is_a: UBERON:0010912 ! subdivision of skeleton relationship: BFO:0000050 UBERON:0014477 ! part of thoracic skeleton relationship: BFO:0000050 UBERON:0014478 ! part of rib skeletal system relationship: RO:0002433 UBERON:0005944 ! contributes to morphology of axial skeleton plus cranial skeleton property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/8/88/Gray112.png" xsd:anyURI [Term] id: UBERON:0003253 name: neck of rib def: "The neck of the rib is the flattened portion which extends lateralward from the head; it is about 2.5 cm. long, and is placed in front of the transverse process of the lower of the two vertebrC& with which the head articulates. Its anterior surface is flat and smooth, its posterior rough for the attachment of the ligament of the neck, and perforated by numerous foramina. Of its two borders the superior presents a rough crest (crista colli costE) for the attachment of the anterior costotransverse ligament; its inferior border is rounded. On the posterior surface at the junction of the neck and body, and nearer the lower than the upper border, is an eminencebthe tubercle; it consists of an articular and a non-articular portion. The articular portion, the lower and more medial of the two, presents a small, oval surface for articulation with the end of the transverse process of the lower of the two vertebrC& to which the head is connected. The non-articular portion is a rough elevation, and affords attachment to the ligament of the tubercle. The tubercle is much more prominent in the upper than in the lower ribs." [Wikipedia:Neck_of_rib] synonym: "collum costae" EXACT OMO:0003011 [Wikipedia:Neck_of_rib] synonym: "collum costae" RELATED OMO:0003011 [Wikipedia:Neck_of_rib] synonym: "rib neck" EXACT [FMA:7576] xref: EMAPA:37826 {source="MA:th"} xref: FMA:7576 xref: SCTID:263359009 xref: Wikipedia:Neck_of_rib is_a: UBERON:0018664 ! neck of bone element intersection_of: UBERON:0001560 ! neck of organ intersection_of: BFO:0000050 UBERON:0002228 ! part of rib relationship: BFO:0000050 UBERON:0010388 {source="PMID:15906248"} ! part of proximal segment of rib property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/5/5c/Gray122.png" xsd:anyURI [Term] id: UBERON:0003254 name: amniotic ectoderm subset: human_reference_atlas synonym: "amnion ectoderm" EXACT [EHDAA2:0000117, OBOL:automatic] synonym: "amnion epithelium" RELATED [BTO:0000897] synonym: "amnionic ectoderm" EXACT [http://placentation.ucsd.edu/glossfs.html, ISBN:9780878932504] xref: BTO:0000897 xref: EHDAA2:0000117 xref: EHDAA:138 xref: EMAPA:16110 xref: VHOG:0000621 is_a: BFO:0000002 is_a: UBERON:0000478 {source="EHDAA2"} ! extraembryonic structure is_a: UBERON:0000490 {source="EHDAA2"} ! unilaminar epithelium is_a: UBERON:0005292 ! extraembryonic tissue relationship: BFO:0000050 UBERON:0000305 {source="EHDAA2"} ! part of amnion relationship: RO:0002202 UBERON:0002532 {source="EHDAA2-via-amnioblasts", source="ISBN:9780878932504"} ! develops from epiblast (generic) property_value: IAO:0000116 "we make the germ layer relationship develops_from, as currently the germ layers are declared to be purely embryonic. TODO - check. WP:Amnion - In the human embryo the earliest stages of the formation of the amnion have not been observed; in the youngest embryo which has been studied the amnion was already present as a closed sac, and appears in the inner cell-mass as a cavity. This cavity is roofed in by a single stratum of flattened, ectodermal cells, the amniotic ectoderm, and its floor consists of the prismatic ectoderm of the embryonic disk-the continuity between the roof and floor being established at the margin of the embryonic disk. Outside the amniotic ectoderm is a thin layer of mesoderm, which is continuous with that of the somatopleure and is connected by the body-stalk with the mesodermal lining of the chorion." xsd:string property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0003257 name: yolk sac endoderm def: "The portion of the yolk sac that is derived from endoderm and lines the yolk sac." [UBERON:cjm] xref: EHDAA2:0002215 xref: EHDAA:166 xref: EMAPA:16086 xref: VHOG:0000626 is_a: UBERON:0000478 {source="EHDAA2"} ! extraembryonic structure is_a: UBERON:0005292 ! extraembryonic tissue is_a: UBERON:0005911 ! endo-epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: RO:0002007 UBERON:0001040 ! bounding layer of yolk sac intersection_of: RO:0002202 UBERON:0000925 ! develops from endoderm relationship: RO:0002007 UBERON:0001040 ! bounding layer of yolk sac property_value: skos:prefLabel "yolk sac endoderm" xsd:string [Term] id: UBERON:0003258 name: endoderm of foregut def: "An endoderm that is part of a foregut [Automatically generated definition]." [OBOL:automatic] synonym: "foregut endoderm" EXACT [OBOL:automatic] xref: EHDAA2:0004568 xref: EHDAA:524 is_a: UBERON:0000490 ! unilaminar epithelium is_a: UBERON:0005911 ! endo-epithelium is_a: UBERON:0015833 ! foregut epithelium intersection_of: UBERON:0000490 ! unilaminar epithelium intersection_of: BFO:0000050 UBERON:0001041 ! part of foregut intersection_of: RO:0002202 UBERON:0000925 ! develops from endoderm property_value: IAO:0000116 "TODO - check" xsd:string property_value: skos:prefLabel "endoderm of foregut" xsd:string [Term] id: UBERON:0003259 name: endoderm of midgut def: "An endoderm that is part of a midgut [Automatically generated definition]." [OBOL:automatic] synonym: "midgut endoderm" EXACT [OBOL:automatic] xref: EHDAA:987 xref: EMAPA:16257 xref: RETIRED_EHDAA2:0001194 xref: VHOG:0001080 is_a: UBERON:0000490 ! unilaminar epithelium is_a: UBERON:0003352 ! epithelium of midgut is_a: UBERON:0005911 ! endo-epithelium intersection_of: UBERON:0000490 ! unilaminar epithelium intersection_of: BFO:0000050 UBERON:0001045 ! part of midgut intersection_of: RO:0002202 UBERON:0000925 ! develops from endoderm property_value: IAO:0000116 "TODO - check" xsd:string property_value: skos:prefLabel "endoderm of midgut" xsd:string [Term] id: UBERON:0003260 name: endoderm of hindgut def: "An endoderm that is part of a hindgut [Automatically generated definition]." [OBOL:automatic] synonym: "hindgut endoderm" EXACT [OBOL:automatic] xref: EHDAA:979 xref: RETIRED_EHDAA2:0000781 is_a: UBERON:0000490 ! unilaminar epithelium is_a: UBERON:0003353 ! epithelium of hindgut is_a: UBERON:0005911 ! endo-epithelium intersection_of: UBERON:0000490 ! unilaminar epithelium intersection_of: BFO:0000050 UBERON:0001046 ! part of hindgut intersection_of: RO:0002202 UBERON:0000925 ! develops from endoderm property_value: IAO:0000116 "TODO - check" xsd:string property_value: skos:prefLabel "endoderm of hindgut" xsd:string [Term] id: UBERON:0003261 name: thyroid primordium endoderm def: "An endoderm that is part of a thyroid primordium." [OBOL:automatic] synonym: "endoderm of thyroid primordium" EXACT [OBOL:automatic] xref: EHDAA:956 xref: EMAPA:25357 xref: RETIRED_EHDAA2:0002035 xref: VHOG:0001089 is_a: UBERON:0000925 ! endoderm is_a: UBERON:0004119 ! endoderm-derived structure intersection_of: UBERON:0000925 ! endoderm intersection_of: BFO:0000050 UBERON:0003091 ! part of thyroid primordium relationship: BFO:0000050 UBERON:0003091 ! part of thyroid primordium relationship: RO:0002202 UBERON:0007690 {source="ZFA-propagated"} ! develops from early pharyngeal endoderm [Term] id: UBERON:0003262 name: amniotic mesoderm def: "A mesenchyme that is part of a amnion." [OBOL:automatic] subset: human_reference_atlas synonym: "amnion mesenchyme" EXACT [EHDAA2:0000118] synonym: "amnion mesoderm" EXACT [OBOL:automatic] synonym: "amnionic mesenchyme" RELATED [EMAPA:16265] synonym: "amnionic mesoderm" EXACT [http://placentation.ucsd.edu/glossfs.html] synonym: "amnionic mesoderm" RELATED [EMAPA:16111] synonym: "mesenchyme of amnion" EXACT [EMAPA:16265] xref: EHDAA2:0000118 xref: EHDAA:140 xref: EMAPA:16111 xref: EMAPA:16265 xref: VHOG:0000622 is_a: UBERON:0000478 {source="EHDAA2"} ! extraembryonic structure is_a: UBERON:0007524 {source="EHDAA2"} ! dense mesenchyme tissue is_a: UBERON:0010333 ! extraembryonic membrane mesenchyme intersection_of: UBERON:0003104 ! mesenchyme intersection_of: BFO:0000050 UBERON:0000305 ! part of amnion relationship: BFO:0000050 UBERON:0000305 ! part of amnion property_value: IAO:0000116 "we make the germ layer relationship develops_from, as currently the germ layers are declared to be purely embryonic. TODO - check. WP:Amnion - In the human embryo the earliest stages of the formation of the amnion have not been observed; in the youngest embryo which has been studied the amnion was already present as a closed sac, and appears in the inner cell-mass as a cavity. This cavity is roofed in by a single stratum of flattened, ectodermal cells, the amniotic ectoderm, and its floor consists of the prismatic ectoderm of the embryonic disk-the continuity between the roof and floor being established at the margin of the embryonic disk. Outside the amniotic ectoderm is a thin layer of mesoderm, which is continuous with that of the somatopleure and is connected by the body-stalk with the mesodermal lining of the chorion." xsd:string property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0003265 name: chorionic mesenchyme def: "A mesenchyme that is part of a chorion." [OBOL:automatic] synonym: "chorion mesenchyme" EXACT [OBOL:automatic] synonym: "chorion mesoderm" EXACT [RETIRED_EHDAA2:0000247] synonym: "chorionic mesenchyme" EXACT [EHDAA2:0003245] synonym: "mesenchyme of chorion" EXACT [] synonym: "mesenchyme of chorion (vertebrates)" EXACT [OBOL:automatic] xref: EHDAA2:0003245 xref: EHDAA:154 xref: EMAPA:16114 xref: EMAPA:16266 xref: RETIRED_EHDAA2:0000247 xref: VHOG:0000620 is_a: UBERON:0000478 {source="EHDAA2"} ! extraembryonic structure is_a: UBERON:0007524 {source="EHDAA2"} ! dense mesenchyme tissue is_a: UBERON:0010333 ! extraembryonic membrane mesenchyme intersection_of: UBERON:0003104 ! mesenchyme intersection_of: BFO:0000050 UBERON:0003124 ! part of chorion membrane relationship: BFO:0000050 UBERON:0003124 ! part of chorion membrane relationship: RO:0002202 UBERON:0004871 {source="ISBN:0073040584"} ! develops from somatic layer of lateral plate mesoderm property_value: IAO:0000116 "TODO - check" xsd:string [Term] id: UBERON:0003267 name: tooth of upper jaw def: "A calcareous tooth that is part of the upper jaw region. In mammals, the upper jaw teeth are attached to the maxilla." [http://orcid.org/0000-0002-6601-2165] synonym: "maxillary tooth" NARROW [NCBITaxon:40674] synonym: "upper jaw tooth" EXACT [MA:0001909] xref: EHDAA:8045 xref: EMAPA:17938 xref: MA:0001909 xref: NCIT:C49792 xref: SCTID:422279005 xref: UMLS:C1710581 {source="ncithesaurus:Upper_Jaw_Tooth"} is_a: UBERON:0001091 ! calcareous tooth is_a: UBERON:0013765 ! digestive system element intersection_of: UBERON:0001091 ! calcareous tooth intersection_of: BFO:0000050 UBERON:0001709 ! part of upper jaw region relationship: BFO:0000050 UBERON:0009680 ! part of set of upper jaw teeth relationship: RO:0002371 UBERON:0011597 ! attached to bone of upper jaw property_value: IAO:0000116 "Note that we follow EHDAA2 and consider teeth part of the jaw skeleton" xsd:string [Term] id: UBERON:0003268 name: tooth of lower jaw def: "A calcareous tooth that is part of the lower jaw region. In mammals, the lower jaw teeth are attached to the mandible (dentary)." [http://orcid.org/0000-0002-6601-2165] synonym: "calcareous tooth of lower jaw" EXACT [OBOL:automatic] synonym: "lower jaw calcareous tooth" EXACT [OBOL:automatic] synonym: "lower jaw dentine containing tooth" EXACT [OBOL:automatic] synonym: "lower jaw tooth" EXACT [OBOL:automatic] synonym: "lower jaw vertebrate tooth" EXACT [OBOL:automatic] synonym: "mandibular tooth" NARROW [NCBITaxon:40674] xref: EHDAA:8009 xref: EMAPA:17917 xref: FMA:321647 xref: MA:0001907 xref: NCIT:C49582 xref: SCTID:422032003 xref: UMLS:C1708757 {source="ncithesaurus:Lower_Jaw_Tooth"} is_a: UBERON:0001091 ! calcareous tooth is_a: UBERON:0013765 ! digestive system element intersection_of: UBERON:0001091 ! calcareous tooth intersection_of: BFO:0000050 UBERON:0001710 ! part of lower jaw region relationship: BFO:0000050 UBERON:0009679 ! part of set of lower jaw teeth relationship: RO:0002371 UBERON:0004768 ! attached to bone of lower jaw [Term] id: UBERON:0003269 name: skeletal muscle tissue of eye def: "A portion of skeletal muscle tissue that is part of a eye [Automatically generated definition]." [OBOL:automatic] synonym: "eye skeletal muscle" EXACT [OBOL:automatic] synonym: "eye skeletal muscle group" RELATED [EHDAA2:0000486] synonym: "eye skeletal muscle tissue" EXACT [OBOL:automatic] synonym: "skeletal muscle tissue of eye" EXACT [OBOL:automatic] xref: EHDAA2:0000486 xref: EHDAA:2923 xref: EMAPA:17844 is_a: UBERON:0001134 ! skeletal muscle tissue intersection_of: UBERON:0001134 ! skeletal muscle tissue intersection_of: BFO:0000050 UBERON:0000019 ! part of camera-type eye relationship: BFO:0000050 UBERON:0000019 ! part of camera-type eye property_value: skos:prefLabel "skeletal muscle tissue of eye" xsd:string [Term] id: UBERON:0003277 name: skeleton of upper jaw def: "A subdivision of the skeleton that corresponds to the upper part of the mouth. The lower jaw skeleton includes the following elements, when present: upper jaw teeth, the maxilla and other lower jaw bones." [http://orcid.org/0000-0002-6601-2165] subset: pheno_slim synonym: "upper jaw" BROAD [MA:0001908] synonym: "upper jaw skeleton" EXACT [] xref: AAO:0000622 xref: EHDAA2:0002128 xref: EHDAA:8041 xref: EMAPA:17927 xref: FMA:54397 xref: MA:0001908 xref: VHOG:0000429 xref: XAO:0003087 is_a: UBERON:0010912 ! subdivision of skeleton intersection_of: UBERON:0010912 ! subdivision of skeleton intersection_of: RO:0002576 UBERON:0001709 ! skeleton of upper jaw region relationship: BFO:0000050 UBERON:0001708 ! part of jaw skeleton relationship: RO:0002576 UBERON:0001709 ! skeleton of upper jaw region property_value: skos:prefLabel "skeleton of upper jaw" xsd:string [Term] id: UBERON:0003278 name: skeleton of lower jaw def: "A subdivision of the skeleton that corresponds to the lower part of the mouth. The lower jaw skeleton includes the following elements, when present: lower jaw teeth, the mandible and other lower jaw bones, and Meckel's cartilage." [http://orcid.org/0000-0002-6601-2165] subset: pheno_slim synonym: "lower jaw" BROAD [MA:0001906, ZFA:0001273] synonym: "lower jaw skeleton" EXACT [AAO:0000274] synonym: "mandible" BROAD [ZFA:0001273] synonym: "mandibles" RELATED OMO:0003004 [TAO:0001273] synonym: "mandibular series" RELATED [ZFA:0001273] xref: AAO:0000274 xref: EHDAA2:0004606 xref: EHDAA:8005 xref: EMAPA:17910 xref: FMA:54398 xref: MA:0001906 xref: TAO:0001273 xref: VHOG:0000428 xref: XAO:0003084 xref: ZFA:0001273 is_a: UBERON:0010912 ! subdivision of skeleton intersection_of: UBERON:0010912 ! subdivision of skeleton intersection_of: RO:0002576 UBERON:0001710 ! skeleton of lower jaw region relationship: BFO:0000050 UBERON:0001708 ! part of jaw skeleton relationship: RO:0002131 UBERON:0008895 {source="VHOG-modified"} ! overlaps splanchnocranium relationship: RO:0002576 UBERON:0001710 ! skeleton of lower jaw region property_value: skos:prefLabel "skeleton of lower jaw" xsd:string [Term] id: UBERON:0003279 name: endothelium of trachea def: "An endothelium that is part of a trachea." [OBOL:automatic] synonym: "endothelium of windpipe" EXACT [OBOL:automatic] synonym: "trachea endothelium" EXACT [OBOL:automatic] synonym: "windpipe endothelium" EXACT [OBOL:automatic] xref: EHDAA:3082 xref: RETIRED_EHDAA2:0002068 is_a: UBERON:0000077 ! mixed endoderm/mesoderm-derived structure is_a: UBERON:0001901 ! epithelium of trachea is_a: UBERON:0001986 ! endothelium intersection_of: UBERON:0001986 ! endothelium intersection_of: BFO:0000050 UBERON:0003126 ! part of trachea property_value: skos:prefLabel "endothelium of trachea" xsd:string [Term] id: UBERON:0003281 name: mesentery of stomach def: "The portion of the primitive mesentery that encloses the stomach; from its dorsal sheet, the greater omentum develops, and from its ventral sheet, the lesser omentum." [http://medical-dictionary.thefreedictionary.com/mesogastrium] subset: pheno_slim synonym: "mesentery of ventriculus" EXACT [OBOL:automatic] synonym: "mesogaster" EXACT [http://medical-dictionary.thefreedictionary.com/mesogastrium] synonym: "mesogastium" EXACT [MA:0001617] synonym: "mesogastrium" EXACT [http://www.vivo.colostate.edu/hbooks/pathphys/misc_topics/peritoneum.html] synonym: "stomach mesentery" EXACT [Obol:obol] synonym: "ventriculus mesentery" EXACT [OBOL:automatic] xref: EHDAA2:0001922 xref: EHDAA:2999 xref: EMAPA:17024 xref: MA:0001617 xref: SCTID:261623000 xref: VHOG:0000358 is_a: UBERON:0004854 {source="MA"} ! gastrointestinal system mesentery intersection_of: UBERON:0002095 ! mesentery intersection_of: BFO:0000050 UBERON:0000945 ! part of stomach relationship: BFO:0000050 UBERON:0000945 {source="MA"} ! part of stomach relationship: RO:0002433 UBERON:0000945 ! contributes to morphology of stomach property_value: IAO:0000116 "TODO - check primitive vs developed" xsd:string [Term] id: UBERON:0003282 name: mesentery of heart def: "A mesentery that surrounds the heart." [MA:th] synonym: "cardiac mesentery" RELATED [EMAPA:16212] synonym: "heart mesentery" EXACT [OBOL:automatic] synonym: "mesocardium" RELATED [MA:0000098] xref: EHDAA:432 xref: EMAPA:16212 xref: RETIRED_EHDAA2:0000739 xref: VHOG:0000353 is_a: UBERON:0002095 ! mesentery intersection_of: UBERON:0002095 ! mesentery intersection_of: BFO:0000050 UBERON:0000948 ! part of heart relationship: BFO:0000050 UBERON:0000948 ! part of heart [Term] id: UBERON:0003283 name: mesentery of oesophagus def: "A mesentery that is part of a esophagus [Automatically generated definition]." [OBOL:automatic] synonym: "esophagus mesentery" EXACT [MA:0001569] synonym: "gullet mesentery" EXACT [OBOL:automatic] synonym: "mesentery of esophagus" EXACT [OBOL:automatic] synonym: "mesentery of gullet" EXACT [OBOL:automatic] synonym: "meso-esophagus" EXACT [] synonym: "oesophagus mesentery" EXACT [VHOG:0000415] xref: EHDAA2:0001288 xref: EHDAA:2943 xref: EMAPA:16836 xref: MA:0001569 xref: VHOG:0000415 is_a: UBERON:0001975 ! serosa of esophagus is_a: UBERON:0002095 ! mesentery intersection_of: UBERON:0002095 ! mesentery intersection_of: BFO:0000050 UBERON:0001043 ! part of esophagus [Term] id: UBERON:0003284 name: mesentery of midgut def: "A mesentery that is part of a midgut [Automatically generated definition]." [OBOL:automatic] synonym: "midgut mesentery" EXACT [OBOL:automatic] xref: EHDAA2:0001202 xref: EHDAA:3031 xref: EMAPA:16721 xref: EMAPA:17039 xref: EMAPA:17197 xref: VHOG:0000413 is_a: UBERON:0002095 ! mesentery intersection_of: UBERON:0002095 ! mesentery intersection_of: BFO:0000050 UBERON:0001045 ! part of midgut relationship: BFO:0000050 UBERON:0001045 ! part of midgut [Term] id: UBERON:0003288 name: meninx of midbrain def: "A meninx that is part of a midbrain [Automatically generated definition]." [OBOL:automatic] synonym: "meninges of midbrain" EXACT OMO:0003004 [OBOL:automatic] synonym: "mesencephalon meninges" RELATED OMO:0003004 [VHOG:0000012] synonym: "midbrain meninges" EXACT OMO:0003004 [OBOL:automatic] synonym: "midbrain meninx" EXACT [OBOL:automatic] xref: EHDAA2:0001174 xref: EHDAA:3708 xref: EMAPA:17791 xref: MA:0001058 xref: RETIRED_EHDAA2:0001109 xref: VHOG:0000012 is_a: UBERON:0003547 ! brain meninx intersection_of: UBERON:0002360 ! meninx intersection_of: BFO:0000050 UBERON:0001891 ! part of midbrain relationship: BFO:0000050 UBERON:0001891 ! part of midbrain property_value: IAO:0000116 "consider changing genus to subdivision of meninx" xsd:string property_value: skos:prefLabel "meninx of midbrain" xsd:string [Term] id: UBERON:0003289 name: meninx of telencephalon def: "A meninx that is part of a telencephalon [Automatically generated definition]." [OBOL:automatic] synonym: "meninges of telencephalon" EXACT OMO:0003004 [OBOL:automatic] synonym: "telencephalon meninges" EXACT OMO:0003004 [OBOL:automatic] synonym: "telencephalon meninx" EXACT [OBOL:automatic] xref: EHDAA2:0001990 xref: EHDAA:5476 xref: EMAPA:17774 xref: MA:0000979 xref: VHOG:0000010 is_a: UBERON:0003548 ! forebrain meninges intersection_of: UBERON:0002360 ! meninx intersection_of: BFO:0000050 UBERON:0001893 ! part of telencephalon relationship: BFO:0000050 UBERON:0001893 ! part of telencephalon property_value: IAO:0000116 "consider changing genus to subdivision of meninx" xsd:string property_value: skos:prefLabel "meninx of telencephalon" xsd:string [Term] id: UBERON:0003290 name: meninx of diencephalon def: "A meninx that is part of a diencephalon [Automatically generated definition]." [OBOL:automatic] synonym: "between brain meninges" EXACT [OBOL:automatic] synonym: "between brain meninx" EXACT [OBOL:automatic] synonym: "diencephalon meninges" EXACT [OBOL:automatic] synonym: "diencephalon meninx" EXACT [OBOL:automatic] synonym: "interbrain meninges" EXACT [OBOL:automatic] synonym: "interbrain meninx" EXACT [OBOL:automatic] synonym: "mature diencephalon meninges" EXACT [OBOL:automatic] synonym: "mature diencephalon meninx" EXACT [OBOL:automatic] synonym: "meninges of between brain" EXACT [OBOL:automatic] synonym: "meninges of diencephalon" EXACT [OBOL:automatic] synonym: "meninges of interbrain" EXACT [OBOL:automatic] synonym: "meninges of mature diencephalon" EXACT [OBOL:automatic] synonym: "meninx of between brain" EXACT [OBOL:automatic] synonym: "meninx of interbrain" EXACT [OBOL:automatic] synonym: "meninx of mature diencephalon" EXACT [OBOL:automatic] xref: EHDAA2:0000399 xref: EHDAA:5458 xref: EMAPA:17764 xref: MA:0000826 xref: VHOG:0000009 is_a: UBERON:0003548 ! forebrain meninges intersection_of: UBERON:0002360 ! meninx intersection_of: BFO:0000050 UBERON:0001894 ! part of diencephalon relationship: BFO:0000050 UBERON:0001894 ! part of diencephalon property_value: IAO:0000116 "consider changing genus to subdivision of meninx" xsd:string property_value: skos:prefLabel "meninx of diencephalon" xsd:string [Term] id: UBERON:0003291 name: meninx of hindbrain def: "A meninx that is part of a hindbrain [Automatically generated definition]." [OBOL:automatic] synonym: "hindbrain meninges" EXACT [OBOL:automatic] synonym: "hindbrain meninx" EXACT [OBOL:automatic] synonym: "meninges of hindbrain" EXACT [OBOL:automatic] synonym: "rhomencephalon meninges" RELATED OMO:0003004 [VHOG:0000011] xref: EHDAA2:0000770 xref: EHDAA:3688 xref: EMAPA:17783 xref: MA:0000987 xref: VHOG:0000011 is_a: UBERON:0003547 ! brain meninx intersection_of: UBERON:0002360 ! meninx intersection_of: BFO:0000050 UBERON:0002028 ! part of hindbrain relationship: BFO:0000050 UBERON:0002028 ! part of hindbrain relationship: RO:0002495 UBERON:0010091 {evidence="definitional"} ! immediate transformation of future hindbrain meninx property_value: IAO:0000116 "consider changing genus to subdivision of meninx" xsd:string property_value: skos:prefLabel "meninx of hindbrain" xsd:string [Term] id: UBERON:0003292 name: meninx of spinal cord def: "A meninx that is part of a spinal cord [Automatically generated definition]." [OBOL:automatic] subset: pheno_slim synonym: "menines of spinal cord" EXACT OMO:0003004 [] synonym: "meninges of spinal cord" EXACT [OBOL:automatic] synonym: "spinal cord meninges" EXACT [OBOL:automatic] synonym: "spinal cord meninx" EXACT [OBOL:automatic] synonym: "spinal meninges" EXACT OMO:0003004 [] synonym: "spinal meninx" EXACT [] xref: CALOHA:TS-2148 xref: EHDAA2:0001895 xref: EHDAA:2865 xref: EMAPA:17804 xref: MA:0001130 xref: NCIT:C12350 xref: SCTID:181097002 xref: UMLS:C0037938 {source="ncithesaurus:Spinal_Meninges"} xref: VHOG:0000443 is_a: UBERON:0002360 ! meninx is_a: UBERON:0005174 ! dorsal region element intersection_of: UBERON:0002360 ! meninx intersection_of: BFO:0000050 UBERON:0002240 ! part of spinal cord relationship: BFO:0000050 UBERON:0002240 ! part of spinal cord property_value: skos:prefLabel "meninx of spinal cord" xsd:string [Term] id: UBERON:0003294 name: gland of foregut def: "A gland that is part of a foregut [Automatically generated definition]." [OBOL:automatic] synonym: "foregut gland" EXACT [OBOL:automatic] xref: EHDAA2:0000567 xref: EHDAA:950 xref: EMAPA:16557 xref: VHOG:0000650 is_a: UBERON:0003408 ! gland of digestive tract intersection_of: UBERON:0002530 ! gland intersection_of: BFO:0000050 UBERON:0001041 ! part of foregut relationship: BFO:0000050 UBERON:0001041 ! part of foregut property_value: skos:prefLabel "gland of foregut" xsd:string [Term] id: UBERON:0003295 name: pharyngeal gland def: "Racemose mucous glands beneath the mucous membrane of the pharynx." [http://www.biology-online.org/dictionary/] subset: organ_slim synonym: "glandulae pharyngeae" RELATED [BTO:0004849] synonym: "pharynx gland" EXACT [EHDAA2:0001461] xref: BTO:0004849 xref: EHDAA2:0001461 xref: EHDAA:2967 xref: FMA:55075 is_a: UBERON:0003408 ! gland of digestive tract is_a: UBERON:0036225 ! respiratory system gland intersection_of: UBERON:0002530 ! gland intersection_of: BFO:0000050 UBERON:0001042 ! part of chordate pharynx relationship: BFO:0000050 UBERON:0001042 {source="BTO"} ! part of chordate pharynx property_value: skos:prefLabel "pharyngeal gland" xsd:string [Term] id: UBERON:0003296 name: gland of diencephalon def: "Any gland that is part of the diencephalon. Examples: pineal gland, neurohypophysis." [http://orcid.org/0000-0002-6601-2165] synonym: "diencephalon gland" EXACT [OBOL:automatic] synonym: "interbrain gland" EXACT [OBOL:automatic] xref: EHDAA2:0000395 xref: EMAPA:16897 xref: VHOG:0000653 is_a: UBERON:0002530 ! gland intersection_of: UBERON:0002530 ! gland intersection_of: BFO:0000050 UBERON:0001894 ! part of diencephalon relationship: BFO:0000050 UBERON:0001894 ! part of diencephalon property_value: skos:prefLabel "gland of diencephalon" xsd:string [Term] id: UBERON:0003297 name: gland of integumental system def: "A gland that is part of a integumental system [Automatically generated definition]." [OBOL:automatic] synonym: "integumental gland" EXACT [http://orcid.org/0000-0002-6601-2165] synonym: "integumental system gland" EXACT [http://orcid.org/0000-0002-6601-2165] synonym: "integumentary gland" EXACT [http://orcid.org/0000-0002-6601-2165] xref: EHDAA2:0000837 xref: EMAPA:17758 xref: MA:0000144 xref: VHOG:0000654 is_a: UBERON:0002530 ! gland intersection_of: UBERON:0002530 ! gland intersection_of: BFO:0000050 UBERON:0002416 ! part of integumental system relationship: BFO:0000050 UBERON:0002416 ! part of integumental system property_value: skos:prefLabel "gland of integumental system" xsd:string [Term] id: UBERON:0003299 name: roof plate of midbrain def: "The mesencephalic roof plate, including the caudal and rostral part of the midbrain roof." [MGI:anna, MGI:smb, MP:0006103] subset: pheno_slim subset: vertebrate_core synonym: "midbrain roof" RELATED [EMAPA:16981] synonym: "midbrain roof plate" EXACT [OBOL:automatic] synonym: "midbrain roofplate" EXACT [OBOL:automatic] synonym: "roof plate mesencephalon" RELATED [VHOG:0000772] synonym: "roof plate midbrain" EXACT [VHOG:0000772] synonym: "roof plate midbrain region" EXACT [ZFA:0000355] synonym: "roofplate midbrain" RELATED [VHOG:0000772] synonym: "roofplate of midbrain" EXACT [OBOL:automatic] xref: DHBA:12320 xref: EHDAA2:0001177 xref: EHDAA:3712 xref: EMAPA:16981 xref: RETIRED_EHDAA2:0001111 xref: TAO:0000355 xref: VHOG:0000772 xref: ZFA:0000355 is_a: UBERON:0005291 ! embryonic tissue intersection_of: UBERON:0000479 ! tissue intersection_of: BFO:0000050 UBERON:0001891 ! part of midbrain intersection_of: BFO:0000050 UBERON:0003054 ! part of roof plate relationship: BFO:0000050 UBERON:0001891 ! part of midbrain relationship: BFO:0000050 UBERON:0003054 ! part of roof plate relationship: RO:0002433 UBERON:0001891 ! contributes to morphology of midbrain property_value: skos:prefLabel "roof plate of midbrain" xsd:string [Term] id: UBERON:0003300 name: roof plate of telencephalon def: "A roof plate that is part of a telencephalon [Automatically generated definition]." [OBOL:automatic] synonym: "roof plate telencephalon" EXACT [VHOG:0000774] synonym: "roofplate medulla telencephalon" RELATED [VHOG:0000774] synonym: "roofplate of telencephalon" EXACT [OBOL:automatic] synonym: "telencephalon roof plate" EXACT [OBOL:automatic] synonym: "telencephalon roofplate" EXACT [OBOL:automatic] xref: EHDAA2:0001994 xref: EHDAA:3512 xref: EMAPA:16657 xref: VHOG:0000774 is_a: UBERON:0005291 ! embryonic tissue intersection_of: UBERON:0000479 ! tissue intersection_of: BFO:0000050 UBERON:0001893 ! part of telencephalon intersection_of: BFO:0000050 UBERON:0003054 ! part of roof plate relationship: BFO:0000050 UBERON:0001893 ! part of telencephalon relationship: BFO:0000050 UBERON:0003054 ! part of roof plate property_value: skos:prefLabel "roof plate of telencephalon" xsd:string [Term] id: UBERON:0003301 name: roof plate of diencephalon def: "A roof plate that is part of a diencephalon [Automatically generated definition]." [OBOL:automatic] subset: vertebrate_core synonym: "between brain roof plate" EXACT [OBOL:automatic] synonym: "between brain roofplate" EXACT [OBOL:automatic] synonym: "diencephalon roof plate" EXACT [OBOL:automatic] synonym: "diencephalon roofplate" EXACT [OBOL:automatic] synonym: "interbrain roof plate" EXACT [OBOL:automatic] synonym: "interbrain roofplate" EXACT [OBOL:automatic] synonym: "mature diencephalon roof plate" EXACT [OBOL:automatic] synonym: "mature diencephalon roofplate" EXACT [OBOL:automatic] synonym: "roof plate diencephalic region" EXACT [ZFA:0001358] synonym: "roof plate diencephalon" EXACT [VHOG:0000771] synonym: "roof plate of between brain" EXACT [OBOL:automatic] synonym: "roof plate of interbrain" EXACT [OBOL:automatic] synonym: "roof plate of mature diencephalon" EXACT [OBOL:automatic] synonym: "roofplate medulla diencephalon" RELATED [VHOG:0000771] synonym: "roofplate of between brain" EXACT [OBOL:automatic] synonym: "roofplate of diencephalon" EXACT [OBOL:automatic] synonym: "roofplate of interbrain" EXACT [OBOL:automatic] synonym: "roofplate of mature diencephalon" EXACT [OBOL:automatic] xref: EHDAA2:0000402 xref: EHDAA:1979 xref: EHDAA:2657 xref: EHDAA:3494 xref: EMAPA:16909 xref: TAO:0001358 xref: VHOG:0000771 xref: ZFA:0001358 is_a: UBERON:0005291 ! embryonic tissue intersection_of: UBERON:0000479 ! tissue intersection_of: BFO:0000050 UBERON:0001894 ! part of diencephalon intersection_of: BFO:0000050 UBERON:0003054 ! part of roof plate relationship: BFO:0000050 UBERON:0001894 ! part of diencephalon relationship: BFO:0000050 UBERON:0003054 ! part of roof plate property_value: skos:prefLabel "roof plate of diencephalon" xsd:string [Term] id: UBERON:0003302 name: roof plate of metencephalon def: "A roof plate that is part of a metencephalon [Automatically generated definition]." [OBOL:automatic] synonym: "epencephalon-2 roof plate" EXACT [OBOL:automatic] synonym: "epencephalon-2 roofplate" EXACT [OBOL:automatic] synonym: "metencephalon roof plate" EXACT [OBOL:automatic] synonym: "metencephalon roofplate" EXACT [OBOL:automatic] synonym: "roof plate metencephalon" EXACT [VHOG:0000770] synonym: "roof plate of epencephalon-2" EXACT [OBOL:automatic] synonym: "roofplate medulla metencephalon" RELATED [VHOG:0000770] synonym: "roofplate of epencephalon-2" EXACT [OBOL:automatic] synonym: "roofplate of metencephalon" EXACT [OBOL:automatic] xref: EHDAA2:0001160 xref: EHDAA:5524 xref: VHOG:0000770 is_a: UBERON:0005291 ! embryonic tissue intersection_of: UBERON:0000479 ! tissue intersection_of: BFO:0000050 UBERON:0001895 ! part of metencephalon intersection_of: BFO:0000050 UBERON:0003054 ! part of roof plate relationship: BFO:0000050 UBERON:0001895 ! part of metencephalon relationship: BFO:0000050 UBERON:0003054 ! part of roof plate property_value: skos:prefLabel "roof plate of metencephalon" xsd:string [Term] id: UBERON:0003303 name: roof plate of medulla oblongata def: "A roof plate that is part of a medulla oblongata [Automatically generated definition]." [OBOL:automatic] synonym: "bulb roof plate" EXACT [OBOL:automatic] synonym: "bulb roofplate" EXACT [OBOL:automatic] synonym: "medulla oblongata roof plate" EXACT [OBOL:automatic] synonym: "medulla oblongata roofplate" EXACT [OBOL:automatic] synonym: "medulla oblonmgata roof plate" EXACT [OBOL:automatic] synonym: "medulla oblonmgata roofplate" EXACT [OBOL:automatic] synonym: "metepencephalon roof plate" EXACT [OBOL:automatic] synonym: "metepencephalon roofplate" EXACT [OBOL:automatic] synonym: "roof plate medulla oblongata" EXACT [VHOG:0000776] synonym: "roof plate of bulb" EXACT [OBOL:automatic] synonym: "roof plate of medulla oblonmgata" EXACT [OBOL:automatic] synonym: "roof plate of metepencephalon" EXACT [OBOL:automatic] synonym: "roofplate medulla oblongata" RELATED [VHOG:0000776] synonym: "roofplate of bulb" EXACT [OBOL:automatic] synonym: "roofplate of medulla oblongata" EXACT [OBOL:automatic] synonym: "roofplate of medulla oblonmgata" EXACT [OBOL:automatic] synonym: "roofplate of metepencephalon" EXACT [OBOL:automatic] xref: EHDAA2:0001099 xref: EHDAA:7614 xref: VHOG:0000776 is_a: UBERON:0005291 ! embryonic tissue intersection_of: UBERON:0000479 ! tissue intersection_of: BFO:0000050 UBERON:0001896 ! part of medulla oblongata intersection_of: BFO:0000050 UBERON:0003054 ! part of roof plate relationship: BFO:0000050 UBERON:0001896 ! part of medulla oblongata relationship: BFO:0000050 UBERON:0003054 ! part of roof plate property_value: skos:prefLabel "roof plate of medulla oblongata" xsd:string [Term] id: UBERON:0003304 name: mesoderm blood island def: "A blood island that is part of a mesoderm." [OBOL:automatic] synonym: "mesenchyme blood island" RELATED [OBOL:automatic] synonym: "mesoderm blood islands" EXACT OMO:0003004 [EHDAA2:0003241] xref: EHDAA2:0003241 xref: EHDAA:170 is_a: UBERON:0003061 ! blood island is_a: UBERON:0005291 ! embryonic tissue is_a: UBERON:0007503 {source="EHDAA2"} ! epithelial vesicle is_a: UBERON:0012275 ! meso-epithelium intersection_of: UBERON:0003061 ! blood island intersection_of: BFO:0000050 UBERON:0000926 ! part of mesoderm relationship: BFO:0000050 UBERON:0000926 ! part of mesoderm relationship: BFO:0000050 UBERON:0007798 {source="EHDAA2"} ! part of vascular system property_value: skos:prefLabel "mesoderm blood island" xsd:string [Term] id: UBERON:0003306 name: floor plate of neural tube def: "A floor plate that is part of a neural tube [Automatically generated definition]." [OBOL:automatic] subset: efo_slim subset: vertebrate_core synonym: "floor plate neural tube" EXACT [ZFA:0001434] synonym: "floorplate neural tube" RELATED [VHOG:0000300] synonym: "floorplate of neural tube" EXACT [OBOL:automatic] synonym: "neural tube floor plate" EXACT [OBOL:automatic] synonym: "neural tube floorplate" EXACT [OBOL:automatic] xref: EFO:0003688 xref: EHDAA2:0001256 xref: EHDAA:2871 xref: EHDAA:910 xref: EMAPA:16165 xref: TAO:0001434 xref: VHOG:0000300 xref: ZFA:0001434 is_a: UBERON:0000481 ! multi-tissue structure intersection_of: UBERON:0000481 ! multi-tissue structure intersection_of: BFO:0000050 UBERON:0001049 ! part of neural tube intersection_of: BFO:0000050 UBERON:0003079 ! part of floor plate relationship: BFO:0000050 UBERON:0001049 ! part of neural tube relationship: BFO:0000050 UBERON:0003079 ! part of floor plate property_value: skos:prefLabel "floor plate of neural tube" xsd:string [Term] id: UBERON:0003307 name: floor plate of midbrain def: "A floor plate that is part of a midbrain [Automatically generated definition]." [OBOL:automatic] subset: efo_slim subset: vertebrate_core synonym: "floor plate mesencephalon" RELATED [VHOG:0000780] synonym: "floor plate midbrain" EXACT [VHOG:0000780] synonym: "floor plate midbrain region" EXACT [ZFA:0001677] synonym: "floorplate midbrain" RELATED [VHOG:0000780] synonym: "floorplate of midbrain" EXACT [OBOL:automatic] synonym: "midbrain floor plate" EXACT [OBOL:automatic] synonym: "midbrain floorplate" EXACT [OBOL:automatic] xref: DHBA:12325 xref: EHDAA2:0001164 xref: EHDAA:3698 xref: EMAPA:16975 xref: RETIRED_EHDAA2:0001106 xref: TAO:0002196 xref: VHOG:0000780 xref: ZFA:0001677 is_a: UBERON:0002616 ! regional part of brain is_a: UBERON:0003306 ! floor plate of neural tube intersection_of: UBERON:0000481 ! multi-tissue structure intersection_of: BFO:0000050 UBERON:0001891 ! part of midbrain intersection_of: BFO:0000050 UBERON:0003079 ! part of floor plate relationship: BFO:0000050 UBERON:0001891 ! part of midbrain property_value: skos:prefLabel "floor plate of midbrain" xsd:string [Term] id: UBERON:0003308 name: floor plate of telencephalon def: "A floor plate that is part of a telencephalon [Automatically generated definition]." [OBOL:automatic] subset: vertebrate_core synonym: "floor plate telencephalic region" EXACT [ZFA:0000914] synonym: "floor plate telencephalon" EXACT [VHOG:0000783] synonym: "floorplate of telencephalon" EXACT [OBOL:automatic] synonym: "floorplate telencephalon" EXACT [ZFA:0000914] synonym: "telencephalon floor plate" EXACT [OBOL:automatic] synonym: "telencephalon floorplate" EXACT [OBOL:automatic] xref: EHDAA2:0001983 xref: EHDAA:3498 xref: EMAPA:16655 xref: TAO:0000914 xref: VHOG:0000783 xref: ZFA:0000914 is_a: UBERON:0002616 ! regional part of brain is_a: UBERON:0003306 ! floor plate of neural tube intersection_of: UBERON:0000481 ! multi-tissue structure intersection_of: BFO:0000050 UBERON:0001893 ! part of telencephalon intersection_of: BFO:0000050 UBERON:0003079 ! part of floor plate relationship: BFO:0000050 UBERON:0001893 ! part of telencephalon property_value: skos:prefLabel "floor plate of telencephalon" xsd:string [Term] id: UBERON:0003309 name: floor plate of diencephalon def: "A floor plate that is part of a diencephalon [Automatically generated definition]." [OBOL:automatic] subset: vertebrate_core synonym: "between brain floor plate" EXACT [OBOL:automatic] synonym: "between brain floorplate" EXACT [OBOL:automatic] synonym: "diencephalon floor plate" EXACT [OBOL:automatic] synonym: "diencephalon floorplate" EXACT [OBOL:automatic] synonym: "floor plate diencephalic region" EXACT [ZFA:0000871] synonym: "floor plate diencephalon" EXACT [VHOG:0000782] synonym: "floor plate of between brain" EXACT [OBOL:automatic] synonym: "floor plate of interbrain" EXACT [OBOL:automatic] synonym: "floor plate of mature diencephalon" EXACT [OBOL:automatic] synonym: "floorplate diencephalon" EXACT [ZFA:0000871] synonym: "floorplate of between brain" EXACT [OBOL:automatic] synonym: "floorplate of diencephalon" EXACT [OBOL:automatic] synonym: "floorplate of interbrain" EXACT [OBOL:automatic] synonym: "floorplate of mature diencephalon" EXACT [OBOL:automatic] synonym: "interbrain floor plate" EXACT [OBOL:automatic] synonym: "interbrain floorplate" EXACT [OBOL:automatic] synonym: "mature diencephalon floor plate" EXACT [OBOL:automatic] synonym: "mature diencephalon floorplate" EXACT [OBOL:automatic] xref: EHDAA2:0000388 xref: EHDAA:1975 xref: EHDAA:2651 xref: EHDAA:3480 xref: EMAPA:16903 xref: TAO:0000871 xref: VHOG:0000782 xref: ZFA:0000871 is_a: UBERON:0002616 ! regional part of brain is_a: UBERON:0003306 ! floor plate of neural tube intersection_of: UBERON:0000481 ! multi-tissue structure intersection_of: BFO:0000050 UBERON:0001894 ! part of diencephalon intersection_of: BFO:0000050 UBERON:0003079 ! part of floor plate relationship: BFO:0000050 UBERON:0001894 ! part of diencephalon property_value: skos:prefLabel "floor plate of diencephalon" xsd:string [Term] id: UBERON:0003310 name: floor plate of metencephalon def: "A floor plate that is part of a metencephalon [Automatically generated definition]." [OBOL:automatic] synonym: "epencephalon-2 floor plate" EXACT [OBOL:automatic] synonym: "epencephalon-2 floorplate" EXACT [OBOL:automatic] synonym: "floor plate metencephalon" EXACT [VHOG:0000784] synonym: "floor plate of epencephalon-2" EXACT [OBOL:automatic] synonym: "floorplate metencephalon" RELATED [VHOG:0000784] synonym: "floorplate of epencephalon-2" EXACT [OBOL:automatic] synonym: "floorplate of metencephalon" EXACT [OBOL:automatic] synonym: "metencephalon floor plate" EXACT [OBOL:automatic] synonym: "metencephalon floorplate" EXACT [OBOL:automatic] xref: EHDAA2:0001158 xref: EHDAA:5500 xref: EMAPA:17258 xref: VHOG:0000784 is_a: UBERON:0002616 ! regional part of brain is_a: UBERON:0003306 ! floor plate of neural tube intersection_of: UBERON:0000481 ! multi-tissue structure intersection_of: BFO:0000050 UBERON:0001895 ! part of metencephalon intersection_of: BFO:0000050 UBERON:0003079 ! part of floor plate relationship: BFO:0000050 UBERON:0001895 ! part of metencephalon property_value: skos:prefLabel "floor plate of metencephalon" xsd:string [Term] id: UBERON:0003311 name: floor plate of medulla oblongata def: "A floor plate that is part of a medulla oblongata [Automatically generated definition]." [OBOL:automatic] synonym: "bulb floor plate" EXACT [OBOL:automatic] synonym: "bulb floorplate" EXACT [OBOL:automatic] synonym: "floor plate medulla oblongata" EXACT [VHOG:0000786] synonym: "floor plate of bulb" EXACT [OBOL:automatic] synonym: "floor plate of medulla oblonmgata" EXACT [OBOL:automatic] synonym: "floor plate of metepencephalon" EXACT [OBOL:automatic] synonym: "floorplate medulla oblongata" RELATED [VHOG:0000786] synonym: "floorplate of bulb" EXACT [OBOL:automatic] synonym: "floorplate of medulla oblongata" EXACT [OBOL:automatic] synonym: "floorplate of medulla oblonmgata" EXACT [OBOL:automatic] synonym: "floorplate of metepencephalon" EXACT [OBOL:automatic] synonym: "medulla oblongata floor plate" EXACT [OBOL:automatic] synonym: "medulla oblongata floorplate" EXACT [OBOL:automatic] synonym: "medulla oblonmgata floor plate" EXACT [OBOL:automatic] synonym: "medulla oblonmgata floorplate" EXACT [OBOL:automatic] synonym: "metepencephalon floor plate" EXACT [OBOL:automatic] synonym: "metepencephalon floorplate" EXACT [OBOL:automatic] xref: EHDAA2:0001097 xref: EHDAA:7590 xref: EMAPA:17551 xref: VHOG:0000786 is_a: UBERON:0002616 ! regional part of brain is_a: UBERON:0003306 ! floor plate of neural tube intersection_of: UBERON:0000481 ! multi-tissue structure intersection_of: BFO:0000050 UBERON:0001896 ! part of medulla oblongata intersection_of: BFO:0000050 UBERON:0003079 ! part of floor plate relationship: BFO:0000050 UBERON:0001896 ! part of medulla oblongata property_value: skos:prefLabel "floor plate of medulla oblongata" xsd:string [Term] id: UBERON:0003312 name: mesenchyme of testis def: "Mesenchyme that is part of a developing testis [Automatically generated definition]." [OBOL:automatic] synonym: "testis mesenchyme" EXACT [OBOL:automatic] xref: EHDAA2:0002010 xref: EHDAA:8150 xref: EMAPA:35858 xref: VHOG:0001442 is_a: UBERON:0003855 ! gonad mesenchyme intersection_of: UBERON:0003104 ! mesenchyme intersection_of: BFO:0000050 UBERON:0000473 ! part of testis relationship: BFO:0000050 UBERON:0000473 ! part of testis [Term] id: UBERON:0003314 name: eye mesenchyme def: "Mesenchyme that is part of a developing camera-type eye." [OBOL:automatic] synonym: "mesenchyme of eye" EXACT [OBOL:automatic] xref: EHDAA2:0000485 xref: EHDAA:2910 xref: EMAPA:16673 xref: VHOG:0001084 is_a: BFO:0000002 is_a: UBERON:0009891 ! facial mesenchyme intersection_of: UBERON:0003104 ! mesenchyme intersection_of: BFO:0000050 UBERON:0000019 ! part of camera-type eye relationship: BFO:0000050 UBERON:0000019 ! part of camera-type eye relationship: RO:0002202 UBERON:0009920 {source="EHDAA2"} ! develops from optic neural crest property_value: IAO:0000116 "TODO - change mesenchyme relationships to precursor_of" xsd:string property_value: skos:prefLabel "eye mesenchyme" xsd:string [Term] id: UBERON:0003315 name: mesenchyme of ovary def: "Mesenchyme that is part of a developing ovary [Automatically generated definition]." [OBOL:automatic] subset: human_reference_atlas synonym: "female reproductive system gonad mesenchyme" EXACT [OBOL:automatic] synonym: "female reproductive system gonada mesenchyme" EXACT [OBOL:automatic] synonym: "gonad of female reproductive system mesenchyme" EXACT [OBOL:automatic] synonym: "gonada of female reproductive system mesenchyme" EXACT [OBOL:automatic] synonym: "mesenchyme of female reproductive system gonad" EXACT [OBOL:automatic] synonym: "mesenchyme of female reproductive system gonada" EXACT [OBOL:automatic] synonym: "mesenchyme of gonad of female reproductive system" EXACT [OBOL:automatic] synonym: "mesenchyme of gonada of female reproductive system" EXACT [OBOL:automatic] synonym: "ovary mesenchyme" EXACT [OBOL:automatic] xref: EHDAA2:0001362 xref: EHDAA:8128 xref: VHOG:0001441 is_a: UBERON:0003855 ! gonad mesenchyme intersection_of: UBERON:0003104 ! mesenchyme intersection_of: BFO:0000050 UBERON:0000992 ! part of ovary relationship: BFO:0000050 UBERON:0000992 ! part of ovary property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "mesenchyme of ovary" xsd:string [Term] id: UBERON:0003316 name: mesenchyme of yolk sac def: "The portion of the yolk sac that is derived from mesoderm and consists of mesenchyme." [UBERON:cjm] synonym: "yolk sac mesenchyme" EXACT [OBOL:automatic] xref: EHDAA2:0002216 xref: EHDAA:168 xref: EHDAA:205 xref: EMAPA:16087 xref: EMAPA:16267 xref: VHOG:0000503 xref: VHOG:0000617 is_a: UBERON:0010333 ! extraembryonic membrane mesenchyme intersection_of: UBERON:0003104 ! mesenchyme intersection_of: BFO:0000050 UBERON:0001040 ! part of yolk sac relationship: BFO:0000050 UBERON:0001040 ! part of yolk sac property_value: skos:prefLabel "mesenchyme of yolk sac" xsd:string [Term] id: UBERON:0003318 name: mesenchyme of elbow def: "Mesenchyme that is part of a developing elbow [Automatically generated definition]." [OBOL:automatic] synonym: "cubital region mesenchyme" EXACT [OBOL:automatic] synonym: "elbow mesenchyme" EXACT [OBOL:automatic] synonym: "mesenchyme of cubital region" EXACT [OBOL:automatic] xref: EHDAA2:0000432 xref: EHDAA:4170 xref: EHDAA:6216 xref: EMAPA:17416 xref: VHOG:0001075 is_a: UBERON:0003859 ! forelimb mesenchyme intersection_of: UBERON:0003104 ! mesenchyme intersection_of: BFO:0000050 UBERON:0001461 ! part of elbow relationship: BFO:0000050 UBERON:0001461 ! part of elbow [Term] id: UBERON:0003319 name: mesenchyme of carpal region def: "Mesenchyme of the carpal region that contributes to the carpal skeleton." [https://orcid.org/0000-0002-6601-2165] synonym: "carpal region mesenchyme" EXACT [OBOL:automatic] synonym: "carpus mesenchyme" EXACT [OBOL:automatic] synonym: "mesenchyme of wrist" EXACT [OBOL:automatic] synonym: "wrist mesenchyme" EXACT [OBOL:automatic] xref: EHDAA2:0000220 xref: EHDAA:5200 is_a: UBERON:0003859 ! forelimb mesenchyme intersection_of: UBERON:0003104 ! mesenchyme intersection_of: BFO:0000050 UBERON:0004452 ! part of carpal region relationship: BFO:0000050 UBERON:0004452 ! part of carpal region [Term] id: UBERON:0003320 name: mesenchyme of hip def: "Mesenchyme that is part of a developing hip [Automatically generated definition]." [OBOL:automatic] synonym: "hip mesenchyme" EXACT [OBOL:automatic] synonym: "hip region mesenchyme" EXACT [OBOL:automatic] synonym: "mesenchyme of hip region" EXACT [OBOL:automatic] synonym: "mesenchyme of regio coxae" EXACT [OBOL:automatic] synonym: "regio coxae mesenchyme" EXACT [OBOL:automatic] xref: EHDAA2:0000786 xref: EHDAA:5157 xref: EHDAA:6182 xref: EMAPA:17492 xref: VHOG:0001029 is_a: UBERON:0003104 ! mesenchyme intersection_of: UBERON:0003104 ! mesenchyme intersection_of: BFO:0000050 UBERON:0001464 ! part of hip relationship: BFO:0000050 UBERON:0001464 ! part of hip [Term] id: UBERON:0003321 name: mesenchyme of knee def: "Mesenchyme that is part of a developing knee [Automatically generated definition]." [OBOL:automatic] synonym: "knee mesenchyme" EXACT [OBOL:automatic] xref: EHDAA2:0000898 xref: EHDAA:5163 xref: EHDAA:6188 xref: EMAPA:17495 xref: VHOG:0001070 is_a: UBERON:0003860 ! hindlimb mesenchyme intersection_of: UBERON:0003104 ! mesenchyme intersection_of: BFO:0000050 UBERON:0001465 ! part of knee relationship: BFO:0000050 UBERON:0001465 ! part of knee [Term] id: UBERON:0003322 name: mesenchyme of shoulder def: "Mesenchyme that is part of a developing shoulder [Automatically generated definition]." [OBOL:automatic] synonym: "shoulder mesenchyme" EXACT [OBOL:automatic] xref: EHDAA2:0001837 xref: EHDAA:4184 xref: EHDAA:6232 xref: EMAPA:17423 xref: VHOG:0001035 is_a: UBERON:0003104 ! mesenchyme intersection_of: UBERON:0003104 ! mesenchyme intersection_of: BFO:0000050 UBERON:0001467 ! part of shoulder relationship: BFO:0000050 UBERON:0001467 ! part of shoulder [Term] id: UBERON:0003323 name: mesenchyme of upper jaw def: "Mesenchyme that is part of a developing upper jaw [Automatically generated definition]." [OBOL:automatic] synonym: "mesenchyme of palatoquadrate arch" EXACT [OBOL:automatic] synonym: "palatoquadrate arch mesenchyme" EXACT [OBOL:automatic] synonym: "upper jaw mesenchyme" EXACT [OBOL:automatic] xref: EHDAA2:0002124 xref: EHDAA:8031 xref: EMAPA:17929 xref: VHOG:0001099 is_a: BFO:0000002 is_a: UBERON:0009891 ! facial mesenchyme is_a: UBERON:0034995 ! jaw mesenchyme intersection_of: UBERON:0003104 ! mesenchyme intersection_of: BFO:0000050 UBERON:0001709 ! part of upper jaw region relationship: BFO:0000050 UBERON:0001709 ! part of upper jaw region relationship: RO:0002202 UBERON:0009526 {source="EHDAA2"} ! develops from maxillary process mesenchyme property_value: skos:prefLabel "mesenchyme of upper jaw" xsd:string [Term] id: UBERON:0003324 name: mesenchyme of lower jaw def: "Mesenchyme that is part of a developing lower jaw [Automatically generated definition]." [OBOL:automatic] synonym: "lower jaw mesenchyme" EXACT [OBOL:automatic] synonym: "mesenchyme of ventral mandibular arch" EXACT [OBOL:automatic] synonym: "ventral mandibular arch mesenchyme" EXACT [OBOL:automatic] xref: EHDAA2:0001024 xref: EHDAA:8003 xref: EMAPA:17916 xref: VHOG:0001069 is_a: BFO:0000002 is_a: UBERON:0034995 ! jaw mesenchyme intersection_of: UBERON:0003104 ! mesenchyme intersection_of: BFO:0000050 UBERON:0001710 ! part of lower jaw region relationship: BFO:0000050 UBERON:0001710 ! part of lower jaw region relationship: RO:0002202 UBERON:0006905 {source="EHDAA2"} ! develops from mandibular process mesenchyme property_value: skos:prefLabel "mesenchyme of lower jaw" xsd:string [Term] id: UBERON:0003325 name: mesenchyme of pinna def: "Mesenchyme that is part of a developing pinna [Automatically generated definition]." [OBOL:automatic] synonym: "auricle mesenchyme" EXACT [OBOL:automatic] synonym: "auricle of ear mesenchyme" EXACT [OBOL:automatic] synonym: "auricle of external ear mesenchyme" EXACT [OBOL:automatic] synonym: "auricula (auris externa) mesenchyme" EXACT [OBOL:automatic] synonym: "auricula mesenchyme" EXACT [OBOL:automatic] synonym: "mesenchyme of auricle" EXACT [OBOL:automatic] synonym: "mesenchyme of auricle of ear" EXACT [OBOL:automatic] synonym: "mesenchyme of auricle of external ear" EXACT [OBOL:automatic] synonym: "mesenchyme of auricula" EXACT [OBOL:automatic] synonym: "mesenchyme of auricula (auris externa)" EXACT [OBOL:automatic] synonym: "mesenchyme of pinna of ear" EXACT [OBOL:automatic] synonym: "pinna mesenchyme" EXACT [OBOL:automatic] synonym: "pinna of ear mesenchyme" EXACT [OBOL:automatic] xref: EHDAA2:0001469 xref: EHDAA:8981 xref: EMAPA:17591 xref: VHOG:0000747 is_a: UBERON:0005253 ! head mesenchyme intersection_of: UBERON:0003104 ! mesenchyme intersection_of: BFO:0000050 UBERON:0001757 ! part of pinna relationship: BFO:0000050 UBERON:0001757 ! part of pinna [Term] id: UBERON:0003326 name: mesenchyme of mammary gland def: "Mesenchyme that is part of a developing mammary gland." [OBOL:automatic] synonym: "lactiferous gland mesenchyme" EXACT [OBOL:automatic] synonym: "lobe of breast mesenchyme" EXACT [OBOL:automatic] synonym: "lobe of mammary gland mesenchyme" EXACT [OBOL:automatic] synonym: "mammary gland mesenchyme" EXACT [OBOL:automatic] synonym: "mammary mesenchyme" EXACT [] synonym: "mesenchyme of lactiferous gland" EXACT [OBOL:automatic] synonym: "mesenchyme of lobe of breast" EXACT [OBOL:automatic] synonym: "mesenchyme of lobe of mammary gland" EXACT [OBOL:automatic] xref: EHDAA2:0001058 xref: EHDAA:6528 xref: EMAPA:17761 xref: VHOG:0001087 is_a: UBERON:0003104 ! mesenchyme intersection_of: UBERON:0003104 ! mesenchyme intersection_of: BFO:0000050 UBERON:0001911 ! part of mammary gland relationship: BFO:0000050 UBERON:0001911 ! part of mammary gland [Term] id: UBERON:0003327 name: mesenchyme of forearm def: "Mesenchyme that is part of a developing lower arm [Automatically generated definition]." [OBOL:automatic] xref: EHDAA2:0000555 xref: EHDAA:4176 xref: EHDAA:6222 xref: EMAPA:17419 xref: VHOG:0000504 is_a: UBERON:0003859 ! forelimb mesenchyme intersection_of: UBERON:0003104 ! mesenchyme intersection_of: BFO:0000050 UBERON:0002386 ! part of forelimb zeugopod relationship: BFO:0000050 UBERON:0002386 ! part of forelimb zeugopod [Term] id: UBERON:0003328 name: mesenchyme of footplate def: "Mesenchyme that is part of a footplate." [OBOL:automatic] synonym: "foot plate mesenchyme" EXACT [] xref: EHDAA2:0000549 xref: EHDAA:5149 xref: EHDAA:6172 xref: EMAPA:17252 xref: EMAPA:17488 xref: VHOG_RETIRED:0001055 is_a: UBERON:0010377 ! mesenchyme from somatopleure intersection_of: UBERON:0003104 ! mesenchyme intersection_of: BFO:0000050 UBERON:0006871 ! part of embryonic footplate relationship: BFO:0000050 UBERON:0006871 ! part of embryonic footplate relationship: RO:0002202 UBERON:0003412 {source="EHDAA2"} ! develops from pelvic appendage bud mesenchyme [Term] id: UBERON:0003329 name: submucosa of anal canal def: "A submucosa that is part of an anal canal [Automatically generated definition]." [OBOL:automatic] subset: human_reference_atlas synonym: "anal canal submucosa" EXACT [OBOL:automatic] synonym: "anal canal viewed anatomically submucosa" EXACT [OBOL:automatic] synonym: "anal region submucosa" EXACT [OBOL:automatic] synonym: "anatomical anal canal submucosa" EXACT [OBOL:automatic] synonym: "submucosa of anal canal viewed anatomically" EXACT [OBOL:automatic] synonym: "submucosa of anal region" EXACT [OBOL:automatic] synonym: "submucosa of anatomical anal canal" EXACT [OBOL:automatic] xref: EMAPA:27217 xref: EMAPA:27227 xref: EMAPA:27535 xref: FMA:85399 xref: SCTID:7892006 is_a: UBERON:0001208 ! submucosa of large intestine intersection_of: UBERON:0000009 ! submucosa intersection_of: BFO:0000050 UBERON:0000159 ! part of anal canal relationship: BFO:0000050 UBERON:0000159 ! part of anal canal property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "submucosa of anal canal" xsd:string [Term] id: UBERON:0003330 name: submucosa of rectum def: "The submucous layer of the wall of the rectum." [BTO:0002114] synonym: "rectal submucosa" EXACT [FMA:15034] synonym: "rectum submucosa" EXACT [OBOL:automatic] synonym: "tela submucosa recti" EXACT OMO:0003011 [BTO:0002114] xref: BTO:0002114 xref: EMAPA:27083 xref: FMA:15034 xref: SCTID:71683001 is_a: UBERON:0001208 ! submucosa of large intestine intersection_of: UBERON:0000009 ! submucosa intersection_of: BFO:0000050 UBERON:0001052 ! part of rectum relationship: BFO:0000050 UBERON:0001052 ! part of rectum property_value: skos:prefLabel "submucosa of rectum" xsd:string [Term] id: UBERON:0003331 name: submucosa of colon def: "A submucosa that is part of a colon [Automatically generated definition]." [OBOL:automatic] subset: human_reference_atlas synonym: "colon submucosa" EXACT [OBOL:automatic] synonym: "colonic submucosa" EXACT [FMA:14985] synonym: "large bowel submucosa" EXACT [OBOL:automatic] synonym: "submucosa of large bowel" EXACT [OBOL:automatic] xref: EMAPA:27379 xref: FMA:14985 xref: MA:0003200 xref: SCTID:61647009 is_a: UBERON:0001208 ! submucosa of large intestine intersection_of: UBERON:0000009 ! submucosa intersection_of: BFO:0000050 UBERON:0001155 ! part of colon relationship: BFO:0000050 UBERON:0001155 ! part of colon property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "submucosa of colon" xsd:string [Term] id: UBERON:0003332 name: submucosa of duodenum def: "A submucosa that is part of a duodenum [Automatically generated definition]." [OBOL:automatic] subset: human_reference_atlas synonym: "doudenal submucosa" EXACT [FMA:14943] synonym: "duodenal submucosa" EXACT [FMA:14943] synonym: "duodenum submucosa" EXACT [OBOL:automatic] xref: EMAPA:27027 xref: EMAPA:27097 xref: EMAPA:27239 xref: FMA:14943 xref: MA:0003213 xref: SCTID:76519004 is_a: UBERON:0001205 ! submucosa of small intestine intersection_of: UBERON:0000009 ! submucosa intersection_of: BFO:0000050 UBERON:0002114 ! part of duodenum relationship: BFO:0000050 UBERON:0002114 ! part of duodenum property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "submucosa of duodenum" xsd:string [Term] id: UBERON:0003333 name: submucosa of jejunum def: "A submucosa that is part of a jejunum [Automatically generated definition]." [OBOL:automatic] subset: human_reference_atlas synonym: "jejunal submucosa" EXACT [FMA:14950] synonym: "jejunum submucosa" EXACT [OBOL:automatic] xref: EMAPA:27111 xref: FMA:14950 xref: SCTID:70192009 is_a: UBERON:0001205 ! submucosa of small intestine intersection_of: UBERON:0000009 ! submucosa intersection_of: BFO:0000050 UBERON:0002115 ! part of jejunum relationship: BFO:0000050 UBERON:0002115 ! part of jejunum property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0003334 name: serosa of rectum def: "A serous membrane that is part of a rectum [Automatically generated definition]." [OBOL:automatic] synonym: "rectal serosa" EXACT [FMA:15039] synonym: "rectum serosa" EXACT [OBOL:automatic] synonym: "rectum serous membrane" EXACT [OBOL:automatic] synonym: "serous membrane of rectum" EXACT [OBOL:automatic] synonym: "visceral peritoneum of rectum" EXACT [FMA:15039] xref: EMAPA:27087 xref: FMA:15039 is_a: UBERON:0001209 ! serosa of large intestine intersection_of: UBERON:0000042 ! serous membrane intersection_of: BFO:0000050 UBERON:0001052 ! part of rectum relationship: BFO:0000050 UBERON:0001052 ! part of rectum property_value: skos:prefLabel "serosa of rectum" xsd:string [Term] id: UBERON:0003335 name: serosa of colon def: "A serous membrane that is part of a colon [Automatically generated definition]." [OBOL:automatic] subset: human_reference_atlas synonym: "colon serosa" EXACT [OBOL:automatic] synonym: "colon serous membrane" EXACT [OBOL:automatic] synonym: "colonic serosa" EXACT [FMA:14990] synonym: "large bowel serosa" EXACT [OBOL:automatic] synonym: "large bowel serous membrane" EXACT [OBOL:automatic] synonym: "serosa of large bowel" EXACT [OBOL:automatic] synonym: "serous membrane of colon" EXACT [OBOL:automatic] synonym: "serous membrane of large bowel" EXACT [OBOL:automatic] synonym: "visceral peritoneum of colon" EXACT [FMA:14990] xref: EMAPA:27387 xref: FMA:14990 xref: MA:0003199 xref: SCTID:90132000 is_a: UBERON:0001209 ! serosa of large intestine intersection_of: UBERON:0000042 ! serous membrane intersection_of: BFO:0000050 UBERON:0001155 ! part of colon relationship: BFO:0000050 UBERON:0001155 ! part of colon property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "serosa of colon" xsd:string [Term] id: UBERON:0003336 name: serosa of duodenum def: "A serous membrane that is part of a duodenum [Automatically generated definition]." [OBOL:automatic] subset: human_reference_atlas synonym: "doudenal serosa" EXACT [FMA:14948] synonym: "duodenal serosa" EXACT [FMA:14948] synonym: "duodenum serosa" EXACT [OBOL:automatic] synonym: "duodenum serous membrane" EXACT [OBOL:automatic] synonym: "serous membrane of duodenum" EXACT [OBOL:automatic] synonym: "visceral peritoneum of duodenum" EXACT [FMA:14948] xref: EMAPA:27247 xref: FMA:14948 xref: MA:0003212 xref: SCTID:1236009 is_a: UBERON:0001206 ! serosa of small intestine intersection_of: UBERON:0000042 ! serous membrane intersection_of: BFO:0000050 UBERON:0002114 ! part of duodenum relationship: BFO:0000050 UBERON:0002114 ! part of duodenum property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "serosa of duodenum" xsd:string [Term] id: UBERON:0003337 name: serosa of jejunum def: "A serous membrane that is part of a jejunum [Automatically generated definition]." [OBOL:automatic] subset: human_reference_atlas synonym: "jejunal serosa" EXACT [FMA:14955] synonym: "jejunum serosa" EXACT [OBOL:automatic] synonym: "jejunum serous membrane" EXACT [OBOL:automatic] synonym: "serous membrane of jejunum" EXACT [OBOL:automatic] synonym: "visceral peritoneum of jejunum" EXACT [FMA:14955] xref: EMAPA:27115 xref: FMA:14955 is_a: UBERON:0001206 ! serosa of small intestine intersection_of: UBERON:0000042 ! serous membrane intersection_of: BFO:0000050 UBERON:0002115 ! part of jejunum relationship: BFO:0000050 UBERON:0002115 ! part of jejunum property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0003338 name: ganglion of peripheral nervous system def: "A spatially aggregated collection of nerve cell bodies in the PNS, consisting of one or more subpopulations that share cell type, chemical phenotype, and connections. (CUMBO)." [BIRNLEX:2548] subset: cumbo synonym: "peripheral nervous system ganglion" EXACT [OBOL:automatic] xref: BIRNLEX:2548 xref: BTO:0001123 xref: EMAPA:32814 xref: MA:0001161 is_a: UBERON:0000045 ! ganglion intersection_of: UBERON:0000045 ! ganglion intersection_of: BFO:0000050 UBERON:0000010 ! part of peripheral nervous system relationship: BFO:0000050 UBERON:0000010 ! part of peripheral nervous system property_value: skos:prefLabel "ganglion of peripheral nervous system" xsd:string [Term] id: UBERON:0003339 name: ganglion of central nervous system def: "A ganglion that is part of a central nervous system [Automatically generated definition]." [OBOL:automatic] synonym: "central nervous system ganglion" EXACT [OBOL:automatic] synonym: "ganglion of neuraxis" EXACT [OBOL:automatic] synonym: "neuraxis ganglion" EXACT [OBOL:automatic] xref: EHDAA2:0000227 xref: EMAPA:16658 xref: FMA:83843 is_a: UBERON:0000045 ! ganglion intersection_of: UBERON:0000045 ! ganglion intersection_of: BFO:0000050 UBERON:0001017 ! part of central nervous system relationship: BFO:0000050 UBERON:0001017 ! part of central nervous system property_value: skos:prefLabel "ganglion of central nervous system" xsd:string [Term] id: UBERON:0003342 name: mucosa of anal canal def: "A mucosa that is part of an anal canal [Automatically generated definition]." [OBOL:automatic] subset: human_reference_atlas synonym: "anal canal mucosa" EXACT [OBOL:automatic] synonym: "anal canal mucosa of organ" EXACT [OBOL:automatic] synonym: "anal canal mucous membrane" EXACT [OBOL:automatic] synonym: "anal canal organ mucosa" EXACT [OBOL:automatic] synonym: "anal canal viewed anatomically mucosa" EXACT [OBOL:automatic] synonym: "anal canal viewed anatomically mucosa of organ" EXACT [OBOL:automatic] synonym: "anal canal viewed anatomically mucous membrane" EXACT [OBOL:automatic] synonym: "anal canal viewed anatomically organ mucosa" EXACT [OBOL:automatic] synonym: "anal mucosa" EXACT [FMA:74654] synonym: "anal mucous membrane" EXACT [FMA:74654] synonym: "anal region mucosa" EXACT [OBOL:automatic] synonym: "anal region mucosa of organ" EXACT [OBOL:automatic] synonym: "anal region mucous membrane" EXACT [OBOL:automatic] synonym: "anal region organ mucosa" EXACT [OBOL:automatic] synonym: "anatomical anal canal mucosa" EXACT [OBOL:automatic] synonym: "anatomical anal canal mucosa of organ" EXACT [OBOL:automatic] synonym: "anatomical anal canal mucous membrane" EXACT [OBOL:automatic] synonym: "anatomical anal canal organ mucosa" EXACT [OBOL:automatic] synonym: "mucosa of anal canal viewed anatomically" EXACT [OBOL:automatic] synonym: "mucosa of anal region" EXACT [OBOL:automatic] synonym: "mucosa of anatomical anal canal" EXACT [OBOL:automatic] synonym: "mucosa of organ of anal canal" EXACT [OBOL:automatic] synonym: "mucosa of organ of anal canal viewed anatomically" EXACT [OBOL:automatic] synonym: "mucosa of organ of anal region" EXACT [OBOL:automatic] synonym: "mucosa of organ of anatomical anal canal" EXACT [OBOL:automatic] synonym: "mucous membrane of anal canal" EXACT [OBOL:automatic] synonym: "mucous membrane of anal canal viewed anatomically" EXACT [OBOL:automatic] synonym: "mucous membrane of anal region" EXACT [OBOL:automatic] synonym: "mucous membrane of anatomical anal canal" EXACT [OBOL:automatic] synonym: "organ mucosa of anal canal" EXACT [OBOL:automatic] synonym: "organ mucosa of anal canal viewed anatomically" EXACT [OBOL:automatic] synonym: "organ mucosa of anal region" EXACT [OBOL:automatic] synonym: "organ mucosa of anatomical anal canal" EXACT [OBOL:automatic] xref: EMAPA:27531 xref: FMA:74654 xref: NCIT:C60784 xref: SCTID:362170004 xref: UMLS:C0227414 {source="ncithesaurus:Anal_Mucosa"} is_a: UBERON:0001207 ! mucosa of large intestine intersection_of: UBERON:0000344 ! mucosa intersection_of: BFO:0000050 UBERON:0000159 ! part of anal canal relationship: BFO:0000050 UBERON:0000159 ! part of anal canal property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "mucosa of anal canal" xsd:string [Term] id: UBERON:0003343 name: mucosa of oral region def: "A mucosa that is part of a oral opening [Automatically generated definition]." [OBOL:automatic] synonym: "mucosa of oral opening" EXACT [OBOL:automatic] synonym: "mucosa of oral part of face" EXACT [OBOL:automatic] synonym: "mucosa of organ of oral opening" EXACT [OBOL:automatic] synonym: "mucosa of organ of oral part of face" EXACT [OBOL:automatic] synonym: "mucosa of organ of oral region" EXACT [OBOL:automatic] synonym: "mucosa of organ of subdivision of mouth" EXACT [OBOL:automatic] synonym: "mucosa of subdivision of mouth" EXACT [OBOL:automatic] synonym: "mucous membrane of oral opening" EXACT [OBOL:automatic] synonym: "mucous membrane of oral part of face" EXACT [OBOL:automatic] synonym: "mucous membrane of oral region" EXACT [OBOL:automatic] synonym: "mucous membrane of subdivision of mouth" EXACT [OBOL:automatic] synonym: "oral opening mucosa" EXACT [OBOL:automatic] synonym: "oral opening mucosa of organ" EXACT [OBOL:automatic] synonym: "oral opening mucous membrane" EXACT [OBOL:automatic] synonym: "oral opening organ mucosa" EXACT [OBOL:automatic] synonym: "oral part of face mucosa" EXACT [OBOL:automatic] synonym: "oral part of face mucosa of organ" EXACT [OBOL:automatic] synonym: "oral part of face mucous membrane" EXACT [OBOL:automatic] synonym: "oral part of face organ mucosa" EXACT [OBOL:automatic] synonym: "oral region mucosa" EXACT [OBOL:automatic] synonym: "oral region mucosa of organ" EXACT [OBOL:automatic] synonym: "oral region mucous membrane" EXACT [OBOL:automatic] synonym: "oral region organ mucosa" EXACT [OBOL:automatic] synonym: "organ mucosa of oral opening" EXACT [OBOL:automatic] synonym: "organ mucosa of oral part of face" EXACT [OBOL:automatic] synonym: "organ mucosa of oral region" EXACT [OBOL:automatic] synonym: "organ mucosa of subdivision of mouth" EXACT [OBOL:automatic] synonym: "subdivision of mouth mucosa" EXACT [OBOL:automatic] synonym: "subdivision of mouth mucosa of organ" EXACT [OBOL:automatic] synonym: "subdivision of mouth mucous membrane" EXACT [OBOL:automatic] synonym: "subdivision of mouth organ mucosa" EXACT [OBOL:automatic] xref: SCTID:362083000 is_a: UBERON:0003729 ! mouth mucosa intersection_of: UBERON:0000344 ! mucosa intersection_of: BFO:0000050 UBERON:0000166 ! part of oral opening relationship: BFO:0000050 UBERON:0000166 ! part of oral opening property_value: skos:prefLabel "mucosa of oral region" xsd:string [Term] id: UBERON:0003346 name: mucosa of rectum def: "A mucosa that is part of a rectum [Automatically generated definition]." [OBOL:automatic] subset: human_reference_atlas synonym: "mucosa of organ of rectum" EXACT [OBOL:automatic] synonym: "mucous membrane of rectum" EXACT [OBOL:automatic] synonym: "organ mucosa of rectum" EXACT [OBOL:automatic] synonym: "rectal mucosa" EXACT [FMA:15033] synonym: "rectal mucous membrane" EXACT [FMA:15033] synonym: "rectum mucosa" EXACT [OBOL:automatic] synonym: "rectum mucosa of organ" EXACT [OBOL:automatic] synonym: "rectum mucous membrane" EXACT [OBOL:automatic] synonym: "rectum organ mucosa" EXACT [OBOL:automatic] xref: CALOHA:TS-2107 xref: EMAPA:27081 xref: FMA:15033 xref: MA:0003218 xref: SCTID:362167003 is_a: UBERON:0001207 ! mucosa of large intestine intersection_of: UBERON:0000344 ! mucosa intersection_of: BFO:0000050 UBERON:0001052 ! part of rectum relationship: BFO:0000050 UBERON:0001052 ! part of rectum property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "mucosa of rectum" xsd:string [Term] id: UBERON:0003350 name: epithelium of mucosa def: "A layer of epithelial cells on the surface of the mucosa." [BTO:0003752] comment: lies on top of lamina propria synonym: "lamina epithelialis mucosa" RELATED [BTO:0003752] synonym: "lamina epithelialis mucosae" RELATED [BTO:0003752] xref: BTO:0003752 is_a: UBERON:0000483 ! epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: BFO:0000050 UBERON:0000344 ! part of mucosa relationship: BFO:0000050 UBERON:0000344 ! part of mucosa property_value: skos:prefLabel "epithelium of mucosa" xsd:string [Term] id: UBERON:0003351 name: pharyngeal epithelium def: "An epithelium that is part of a pharynx [Automatically generated definition]." [OBOL:automatic] subset: vertebrate_core synonym: "epithelial tissue of pharynx" EXACT [OBOL:automatic] synonym: "epithelium of pharynx" EXACT [OBOL:automatic] synonym: "pharynx epithelial tissue" EXACT [OBOL:automatic] synonym: "pharynx epithelium" EXACT [OBOL:automatic] xref: BSA:0000112 xref: BTO:0005240 xref: EMAPA:16708 xref: MA:0002725 xref: RETIRED_EHDAA2:0001460 xref: TAO:0001174 xref: XAO:0003202 xref: ZFA:0001174 is_a: UBERON:0003929 ! digestive tract epithelium is_a: UBERON:0004807 ! respiratory system epithelium is_a: UBERON:0005911 ! endo-epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: BFO:0000050 UBERON:0001042 ! part of chordate pharynx relationship: BFO:0000050 UBERON:0001042 {source="ZFA"} ! part of chordate pharynx relationship: RO:0002202 UBERON:0007690 {source="ZFA"} ! develops from early pharyngeal endoderm property_value: skos:prefLabel "pharyngeal epithelium" xsd:string [Term] id: UBERON:0003352 name: epithelium of midgut def: "An epithelium that is part of a midgut." [OBOL:automatic] synonym: "epithelial tissue of midgut" EXACT [OBOL:automatic] synonym: "midgut epithelial tissue" EXACT [OBOL:automatic] synonym: "midgut epithelium" EXACT [BTO:0005053, OBOL:automatic] xref: BTO:0005053 xref: EHDAA2:0001195 xref: EMAPA:16569 xref: MA:0003205 is_a: UBERON:0003929 ! digestive tract epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: BFO:0000050 UBERON:0001045 ! part of midgut relationship: BFO:0000050 UBERON:0001045 {source="BTO"} ! part of midgut property_value: skos:prefLabel "epithelium of midgut" xsd:string [Term] id: UBERON:0003353 name: epithelium of hindgut def: "An epithelium that is part of a hindgut [Automatically generated definition]." [OBOL:automatic] synonym: "epithelial tissue of hindgut" EXACT [OBOL:automatic] synonym: "hindgut epithelial tissue" EXACT [OBOL:automatic] synonym: "hindgut epithelium" EXACT [OBOL:automatic] xref: EHDAA2:0000782 xref: EMAPA:16717 xref: MA:0003206 is_a: UBERON:0003929 ! digestive tract epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: BFO:0000050 UBERON:0001046 ! part of hindgut relationship: BFO:0000050 UBERON:0001046 ! part of hindgut property_value: skos:prefLabel "epithelium of hindgut" xsd:string [Term] id: UBERON:0003354 name: epithelium of rectum def: "An epithelium that is part of a rectum [Automatically generated definition]." [OBOL:automatic] synonym: "epithelial tissue of rectum" EXACT [OBOL:automatic] synonym: "rectal epithelium" EXACT [FMA:17510] synonym: "rectum epithelial tissue" EXACT [OBOL:automatic] synonym: "rectum epithelium" EXACT [OBOL:automatic] xref: CALOHA:TS-2066 xref: EHDAA2:0001594 xref: EMAPA:17898 xref: FMA:17510 xref: MA:0003219 xref: VHOG:0001037 is_a: UBERON:0001278 ! epithelium of large intestine is_a: UBERON:0016885 ! epithelium of terminal part of digestive tract intersection_of: UBERON:0000483 ! epithelium intersection_of: BFO:0000050 UBERON:0001052 ! part of rectum relationship: BFO:0000050 UBERON:0001052 ! part of rectum property_value: skos:prefLabel "epithelium of rectum" xsd:string [Term] id: UBERON:0003357 name: epithelium of tongue def: "An epithelium that is part of a tongue [Automatically generated definition]." [OBOL:automatic] comment: examples: tongue squamous epithelium, keratined, non-keratinized and parakeratinized epithelium, as well as gustatory epithelium. Note that not all these subtypes are named in individual anatomy ontologies. subset: human_reference_atlas subset: pheno_slim synonym: "epithelial tissue of tongue" EXACT [OBOL:automatic] synonym: "lingual epithelium" RELATED [BTO:0000992] synonym: "tongue epithelial tissue" EXACT [OBOL:automatic] synonym: "tongue epithelium" EXACT [OBOL:automatic] xref: BTO:0000992 xref: CALOHA:TS-1051 xref: EHDAA2:0004598 xref: EMAPA:17881 xref: FMA:284658 xref: MA:0001592 xref: NCIT:C49300 xref: UMLS:C1710436 {source="ncithesaurus:Tongue_Epithelium"} is_a: UBERON:0003929 ! digestive tract epithelium is_a: UBERON:0019304 ! sensory organ epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: BFO:0000050 UBERON:0001723 ! part of tongue relationship: BFO:0000050 UBERON:0001723 ! part of tongue relationship: RO:0002433 UBERON:0001723 ! contributes to morphology of tongue property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "epithelium of tongue" xsd:string [Term] id: UBERON:0003359 name: epithelium of submandibular gland def: "An epithelium that is part of a submandibular gland [Automatically generated definition]." [OBOL:automatic] subset: human_reference_atlas synonym: "epithelial tissue of submandibular gland" EXACT [OBOL:automatic] synonym: "submandibular duct epithelium" RELATED [BTO:0004557] synonym: "submandibular gland duct epithelium" RELATED [BTO:0004557] synonym: "submandibular gland epithelial tissue" EXACT [OBOL:automatic] synonym: "submandibular gland epithelium" EXACT [OBOL:automatic] synonym: "submaxillary gland epithelium" RELATED [EMAPA:18813] xref: BTO:0004557 xref: EMAPA:18813 xref: VHOG:0000989 is_a: UBERON:0003236 ! epithelium of lower jaw is_a: UBERON:0004809 ! salivary gland epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: BFO:0000050 UBERON:0001736 ! part of submandibular gland relationship: BFO:0000050 UBERON:0001736 ! part of submandibular gland property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0003360 name: epithelium of parotid gland def: "An epithelium that is part of a parotid gland [Automatically generated definition]." [OBOL:automatic] subset: human_reference_atlas synonym: "epithelial tissue of parotid gland" EXACT [OBOL:automatic] synonym: "epithelium of parotid" EXACT [OBOL:automatic] synonym: "epithelium of parotid gland" EXACT [OBOL:automatic] synonym: "parotid epithelial tissue" EXACT [OBOL:automatic] synonym: "parotid epithelium" EXACT [OBOL:automatic] synonym: "parotid gland duct epithelium" RELATED [BTO:0004555] synonym: "parotid gland epithelial tissue" EXACT [OBOL:automatic] synonym: "parotid gland epithelium" EXACT [OBOL:automatic] xref: BTO:0004555 xref: EMAPA:18538 xref: VHOG:0001434 is_a: UBERON:0003236 ! epithelium of lower jaw is_a: UBERON:0004809 ! salivary gland epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: BFO:0000050 UBERON:0001831 ! part of parotid gland relationship: BFO:0000050 UBERON:0001831 ! part of parotid gland property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0003361 name: epithelium of sublingual gland def: "An epithelium that is part of a sublingual gland [Automatically generated definition]." [OBOL:automatic] subset: human_reference_atlas synonym: "ductus sublingualis epithelial tissue" EXACT [OBOL:automatic] synonym: "ductus sublingualis epithelium" EXACT [OBOL:automatic] synonym: "epithelial tissue of ductus sublingualis" EXACT [OBOL:automatic] synonym: "epithelial tissue of Rivinus'gland" EXACT [OBOL:automatic] synonym: "epithelial tissue of sublingual gland" EXACT [OBOL:automatic] synonym: "epithelium of ductus sublingualis" EXACT [OBOL:automatic] synonym: "epithelium of Rivinus'gland" EXACT [OBOL:automatic] synonym: "Rivinus'gland epithelial tissue" EXACT [OBOL:automatic] synonym: "Rivinus'gland epithelium" EXACT [OBOL:automatic] synonym: "sublingual duct epithelium" RELATED [BTO:0004559] synonym: "sublingual gland duct epithelium" RELATED [BTO:0004559] synonym: "sublingual gland epithelial tissue" EXACT [OBOL:automatic] synonym: "sublingual gland epithelium" EXACT [OBOL:automatic] xref: BTO:0004559 xref: EMAPA:18810 xref: VHOG:0001098 is_a: UBERON:0004809 ! salivary gland epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: BFO:0000050 UBERON:0001832 ! part of sublingual gland relationship: BFO:0000050 UBERON:0001832 ! part of sublingual gland property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0003364 name: epithelium of right lung def: "An epithelium that is part of a right lung [Automatically generated definition]." [OBOL:automatic] synonym: "epithelial tissue of right lung" EXACT [OBOL:automatic] synonym: "right lung epithelial tissue" EXACT [OBOL:automatic] synonym: "right lung epithelium" EXACT [OBOL:automatic] xref: EMAPA:17663 xref: MA:0003132 is_a: UBERON:0000115 ! lung epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: BFO:0000050 UBERON:0002167 ! part of right lung relationship: BFO:0000050 UBERON:0002167 ! part of right lung property_value: skos:prefLabel "epithelium of right lung" xsd:string [Term] id: UBERON:0003365 name: epithelium of left lung def: "An epithelium that is part of a left lung [Automatically generated definition]." [OBOL:automatic] synonym: "epithelial tissue of left lung" EXACT [OBOL:automatic] synonym: "left lung epithelial tissue" EXACT [OBOL:automatic] synonym: "left lung epithelium" EXACT [OBOL:automatic] xref: EMAPA:17655 xref: MA:0003131 is_a: UBERON:0000115 ! lung epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: BFO:0000050 UBERON:0002168 ! part of left lung relationship: BFO:0000050 UBERON:0002168 ! part of left lung property_value: skos:prefLabel "epithelium of left lung" xsd:string [Term] id: UBERON:0003367 name: epithelium of vomeronasal organ def: "An epithelium that is part of a vomeronasal organ [Automatically generated definition]." [OBOL:automatic] synonym: "epithelial tissue of Jacobson's organ" EXACT [OBOL:automatic] synonym: "epithelial tissue of vomeronasal organ" EXACT [OBOL:automatic] synonym: "epithelium of Jacobson's organ" EXACT [OBOL:automatic] synonym: "Jacobson's organ epithelial tissue" EXACT [OBOL:automatic] synonym: "Jacobson's organ epithelium" EXACT [OBOL:automatic] synonym: "vomeronasal epithelium" EXACT [EHDAA2:0004102] synonym: "vomeronasal organ epithelial tissue" EXACT [OBOL:automatic] synonym: "vomeronasal organ epithelium" EXACT [OBOL:automatic] synonym: "vomeronasal organ sensory epithelium" EXACT [MA:0001328] xref: EHDAA2:0004102 xref: EMAPA:18444 xref: FMA:301283 xref: MA:0001328 is_a: UBERON:0000490 {source="EHDAA2"} ! unilaminar epithelium is_a: UBERON:0010371 ! ecto-epithelium is_a: UBERON:0019306 ! nose epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: BFO:0000050 UBERON:0002255 ! part of vomeronasal organ relationship: BFO:0000050 UBERON:0002255 ! part of vomeronasal organ relationship: RO:0002202 UBERON:0001997 {source="EHDAA2"} ! develops from olfactory epithelium property_value: IAO:0000116 "TODO - add cell types" xsd:string property_value: skos:prefLabel "epithelium of vomeronasal organ" xsd:string [Term] id: UBERON:0003371 name: pelvic appendage bud ectoderm def: "An unilaminar epithelium that surrounds a pelvic appendage bud." [OBOL:automatic] synonym: "hindlimb bud ectoderm" NARROW SENSU [EMAPA:16780] synonym: "hindlimb ectoderm" EXACT [VHOG:0001048] synonym: "hindlimb ectoderm" NARROW SENSU [VHOG:0001048] synonym: "leg ectoderm" RELATED [OBOL:automatic] synonym: "lower limb bud ectoderm" NARROW SENSU [EHDAA2:0001034] synonym: "pelvic fin bud ectoderm" NARROW SENSU [] xref: EHDAA2:0001034 xref: EMAPA:16780 xref: VHOG:0001048 is_a: BFO:0000002 is_a: UBERON:0000490 ! unilaminar epithelium is_a: UBERON:0005291 ! embryonic tissue intersection_of: UBERON:0000490 ! unilaminar epithelium intersection_of: RO:0002007 UBERON:0005420 ! bounding layer of pelvic appendage bud relationship: BFO:0000050 UBERON:0000076 {source="EHDAA2"} ! part of external ectoderm relationship: RO:0002007 UBERON:0005420 ! bounding layer of pelvic appendage bud relationship: RO:0002202 UBERON:0000076 {source="EHDAA2"} ! develops from external ectoderm [Term] id: UBERON:0003372 name: pectoral appendage bud ectoderm def: "An unilaminar epithelium that surrounds a pectoral appendage bud." [OBOL:automatic] synonym: "arm ectoderm" RELATED [OBOL:automatic] synonym: "forelimb bud ectoderm" NARROW SENSU [EMAPA:16407] synonym: "forelimb ectoderm" NARROW SENSU [VHOG:0001047] synonym: "pectoral fin bud ectoderm" NARROW SENSU [] synonym: "upper limb bud ectoderm" NARROW SENSU [EHDAA2:0002134] synonym: "wing ectoderm" NARROW SENSU [Geisha:syn, NCBITaxon:8782] xref: EHDAA2:0002134 xref: EMAPA:16407 xref: VHOG:0001047 is_a: BFO:0000002 is_a: UBERON:0000490 ! unilaminar epithelium is_a: UBERON:0005291 ! embryonic tissue intersection_of: UBERON:0000490 ! unilaminar epithelium intersection_of: RO:0002007 UBERON:0005419 ! bounding layer of pectoral appendage bud relationship: BFO:0000050 UBERON:0000076 {source="EHDAA2"} ! part of external ectoderm relationship: RO:0002007 UBERON:0005419 ! bounding layer of pectoral appendage bud relationship: RO:0002202 UBERON:0000076 {source="EHDAA2"} ! develops from external ectoderm property_value: skos:prefLabel "pectoral appendage bud ectoderm" xsd:string [Term] id: UBERON:0003373 name: ectoderm of footplate def: "An ectoderm that is part of a footplate." [OBOL:automatic] xref: EMAPA:17250 is_a: UBERON:0000924 ! ectoderm intersection_of: UBERON:0000924 ! ectoderm intersection_of: BFO:0000050 UBERON:0006871 ! part of embryonic footplate relationship: BFO:0000050 UBERON:0006871 ! part of embryonic footplate [Term] id: UBERON:0003374 name: chorionic ectoderm def: "An extraembryonic structure that develops_from a ectoderm and is part of a chorion." [OBOL:automatic] synonym: "chorion ectoderm" EXACT [OBOL:automatic] synonym: "chorion epithelium" RELATED [] synonym: "chorionic epithelium" RELATED [BTO:0005145] xref: BTO:0005145 xref: EMAPA:16113 is_a: BFO:0000002 is_a: UBERON:0000478 ! extraembryonic structure intersection_of: UBERON:0000478 ! extraembryonic structure intersection_of: BFO:0000050 UBERON:0003124 ! part of chorion membrane intersection_of: RO:0002202 UBERON:0000924 ! develops from ectoderm relationship: BFO:0000050 UBERON:0003124 ! part of chorion membrane relationship: RO:0002202 UBERON:0000924 {source="ISBN:0073040584"} ! develops from ectoderm [Term] id: UBERON:0003379 name: cardiac muscle of right atrium def: "A portion of cardiac muscle tissue that is part of a right atrium [Automatically generated definition]." [OBOL:automatic] subset: human_reference_atlas synonym: "cardiac muscle of cardiac right atrium" EXACT [OBOL:automatic] synonym: "cardiac muscle of heart right atrium" EXACT [OBOL:automatic] synonym: "cardiac muscle tissue of heart right atrium" EXACT [OBOL:automatic] synonym: "cardiac muscle tissue of right atrium" EXACT [OBOL:automatic] synonym: "cardiac muscle tissue of right atrium of heart" EXACT [OBOL:automatic] synonym: "myocardium of right atrium" EXACT [] synonym: "right atrium heart muscle" EXACT [EHDAA2:0004155] synonym: "right atrium myocardium" EXACT [VHOG:0001227] synonym: "textus muscularis of myocardium of right atrium" EXACT [OBOL:automatic] synonym: "textus muscularis of myocardium of right atrium of heart" EXACT [OBOL:automatic] synonym: "textus muscularis of myocardium of right cardiac atrium" EXACT [OBOL:automatic] xref: EHDAA2:0004155 xref: EMAPA:17326 xref: FMA:7282 xref: SCTID:362018002 xref: VHOG:0001227 is_a: UBERON:0004490 ! cardiac muscle tissue of atrium intersection_of: UBERON:0001133 ! cardiac muscle tissue intersection_of: BFO:0000050 UBERON:0002078 ! part of right cardiac atrium relationship: BFO:0000050 UBERON:0002078 ! part of right cardiac atrium property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "cardiac muscle of right atrium" xsd:string [Term] id: UBERON:0003380 name: cardiac muscle of left atrium def: "A portion of cardiac muscle tissue that is part of a left atrium [Automatically generated definition]." [OBOL:automatic] subset: human_reference_atlas synonym: "cardiac left atrium cardiac muscle" EXACT [OBOL:automatic] synonym: "cardiac left atrium cardiac muscle tissue" EXACT [OBOL:automatic] synonym: "cardiac muscle of cardiac left atrium" EXACT [OBOL:automatic] synonym: "cardiac muscle of heart left atrium" EXACT [OBOL:automatic] synonym: "cardiac muscle of left atrium of heart" EXACT [OBOL:automatic] synonym: "left atrium heart muscle" EXACT [EHDAA2:0004154] synonym: "left atrium myocardium" EXACT [VHOG:0001225] synonym: "myocardium of left atrium" EXACT [] synonym: "textus muscularis of myocardium of cardiac left atrium" EXACT [OBOL:automatic] synonym: "textus muscularis of myocardium of heart left atrium" EXACT [OBOL:automatic] synonym: "textus muscularis of myocardium of left atrium" EXACT [OBOL:automatic] synonym: "textus muscularis of myocardium of left atrium of heart" EXACT [OBOL:automatic] synonym: "textus muscularis of myocardium of left cardiac atrium" EXACT [OBOL:automatic] xref: EHDAA2:0004154 xref: EMAPA:17320 xref: FMA:7285 xref: SCTID:189936008 xref: VHOG:0001225 is_a: UBERON:0004490 ! cardiac muscle tissue of atrium intersection_of: UBERON:0001133 ! cardiac muscle tissue intersection_of: BFO:0000050 UBERON:0002079 ! part of left cardiac atrium relationship: BFO:0000050 UBERON:0002079 ! part of left cardiac atrium property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "cardiac muscle of left atrium" xsd:string [Term] id: UBERON:0003381 name: cardiac muscle of right ventricle def: "A portion of cardiac muscle tissue that is part of a right ventricle [Automatically generated definition]." [OBOL:automatic] synonym: "cardiac muscle tissue of right ventricle" EXACT [FMA:83452] synonym: "right ventricle cardiac muscle" RELATED [VHOG:0001236] synonym: "right ventricular cardiac muscle tissue" EXACT [GO:0003221] xref: EMAPA:17342 xref: FMA:83452 xref: VHOG:0001236 is_a: UBERON:0018649 ! cardiac muscle tissue of ventricle intersection_of: UBERON:0001133 ! cardiac muscle tissue intersection_of: BFO:0000050 UBERON:0002080 ! part of heart right ventricle relationship: BFO:0000050 UBERON:0002080 ! part of heart right ventricle property_value: skos:prefLabel "cardiac muscle of right ventricle" xsd:string [Term] id: UBERON:0003382 name: cardiac muscle of left ventricle def: "A portion of cardiac muscle tissue that is part of a left ventricle [Automatically generated definition]." [OBOL:automatic] synonym: "cardiac muscle tissue of left ventricle" EXACT [FMA:83453] synonym: "left ventricle cardiac muscle" RELATED [VHOG:0001234] synonym: "left ventricular cardiac muscle tissue" EXACT [GO:0003220] xref: EMAPA:17339 xref: FMA:83453 xref: VHOG:0001234 is_a: UBERON:0018649 ! cardiac muscle tissue of ventricle intersection_of: UBERON:0001133 ! cardiac muscle tissue intersection_of: BFO:0000050 UBERON:0002084 ! part of heart left ventricle relationship: BFO:0000050 UBERON:0002084 ! part of heart left ventricle property_value: skos:prefLabel "cardiac muscle of left ventricle" xsd:string [Term] id: UBERON:0003383 name: cardiac muscle tissue of interventricular septum def: "A portion of cardiac muscle tissue that is part of an interventricular septum [Automatically generated definition]." [OBOL:automatic] subset: human_reference_atlas synonym: "cardiac muscle of interventricular septum" EXACT [] synonym: "cardiac muscle tissue of interventricular septum" EXACT [FMA:84084] synonym: "interventricular septum cardiac muscle" EXACT [VHOG:0000999] synonym: "interventricular septum heart muscle" EXACT [EHDAA2:0004158] synonym: "interventricular septum muscle" RELATED [http://orcid.org/0000-0002-6601-2165] synonym: "interventricular septum myocardium" EXACT [VHOG:0000999] xref: EHDAA2:0004158 xref: EMAPA:17335 xref: FMA:84084 xref: VHOG:0000999 is_a: UBERON:0004492 ! cardiac muscle tissue of cardiac septum is_a: UBERON:0004667 ! interventricular septum muscular part intersection_of: UBERON:0001133 ! cardiac muscle tissue intersection_of: BFO:0000050 UBERON:0002094 ! part of interventricular septum property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "cardiac muscle tissue of interventricular septum" xsd:string [Term] id: UBERON:0003384 name: skeletal muscle tissue of pharynx def: "A portion of skeletal muscle tissue that is part of a pharynx [Automatically generated definition]." [OBOL:automatic] synonym: "pharynx skeletal muscle" EXACT [OBOL:automatic] synonym: "pharynx skeletal muscle tissue" EXACT [OBOL:automatic] synonym: "skeletal muscle tissue of pharynx" EXACT [OBOL:automatic] xref: EMAPA:18963 is_a: UBERON:0004830 ! respiratory system skeletal muscle intersection_of: UBERON:0001134 ! skeletal muscle tissue intersection_of: BFO:0000050 UBERON:0001042 ! part of chordate pharynx relationship: BFO:0000050 UBERON:0001042 ! part of chordate pharynx property_value: skos:prefLabel "skeletal muscle tissue of pharynx" xsd:string [Term] id: UBERON:0003386 name: smooth muscle of eye def: "Any of the striated muscles that move the eye and include: superior rectus, inferior rectus, medial rectus, lateral rectus, superior oblique, inferior oblique, retractor bulbi." [MGI:cwg, MP:0005247] subset: pheno_slim synonym: "ocular smooth muscle" EXACT [MA:0001268] xref: EMAPA:18807 xref: MA:0001268 is_a: UBERON:0001135 ! smooth muscle tissue intersection_of: UBERON:0001135 ! smooth muscle tissue intersection_of: BFO:0000050 UBERON:0000019 ! part of camera-type eye relationship: BFO:0000050 UBERON:0000019 ! part of camera-type eye relationship: RO:0002433 UBERON:0001015 ! contributes to morphology of musculature property_value: IAO:0000116 "Not clear if we need this and intra-ocular muscle. See issue #331. MA includes ciliary and iris smooth muscle" xsd:string property_value: skos:prefLabel "smooth muscle of eye" xsd:string [Term] id: UBERON:0003387 name: smooth muscle of trachea def: "A portion of smooth muscle tissue that is part of a trachea [Automatically generated definition]." [OBOL:automatic] subset: human_reference_atlas subset: pheno_slim synonym: "trachea smooth muscle" EXACT [MA:0001863] synonym: "tracheal smooth muscle" EXACT [BTO:0001391] xref: BTO:0001391 xref: EMAPA:19192 xref: FMA:262010 xref: MA:0001863 xref: NCIT:C49306 xref: UMLS:C1710458 {source="ncithesaurus:Trachea_Smooth_Muscle_Tissue"} is_a: UBERON:0004233 ! lower respiratory tract smooth muscle intersection_of: UBERON:0001135 ! smooth muscle tissue intersection_of: BFO:0000050 UBERON:0003126 ! part of trachea relationship: BFO:0000050 UBERON:0003126 ! part of trachea relationship: RO:0002433 UBERON:0003126 ! contributes to morphology of trachea property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "smooth muscle of trachea" xsd:string [Term] id: UBERON:0003388 name: mesothelium of pericardial cavity def: "A mesothelium that is part of a pericardium [Automatically generated definition]." [OBOL:automatic] synonym: "cavity of pericardial sac meso-epithelium" EXACT [OBOL:automatic] synonym: "cavity of pericardial sac mesothelium" EXACT [OBOL:automatic] synonym: "meso-epithelium of cavity of pericardial sac" EXACT [OBOL:automatic] synonym: "meso-epithelium of pericardial cavity" EXACT [OBOL:automatic] synonym: "mesothelium of cavity of pericardial sac" EXACT [OBOL:automatic] synonym: "pericardial cavity meso-epithelium" EXACT [OBOL:automatic] synonym: "pericardial cavity mesothelium" EXACT [OBOL:automatic] xref: RETIRED_EHDAA2:0001436 is_a: UBERON:0001136 ! mesothelium intersection_of: UBERON:0001136 ! mesothelium intersection_of: BFO:0000050 UBERON:0002407 ! part of pericardium relationship: BFO:0000050 UBERON:0002407 ! part of pericardium property_value: skos:prefLabel "mesothelium of pericardial cavity" xsd:string [Term] id: UBERON:0003389 name: mesothelium of diaphragm def: "A mesothelium that is part of a diaphragm [Automatically generated definition]." [OBOL:automatic] synonym: "diaphragm meso-epithelium" EXACT [OBOL:automatic] synonym: "diaphragm mesothelium" EXACT [OBOL:automatic] synonym: "meso-epithelium of diaphragm" EXACT [OBOL:automatic] synonym: "meso-epithelium of thoracic diaphragm" EXACT [OBOL:automatic] synonym: "mesothelium of thoracic diaphragm" EXACT [OBOL:automatic] synonym: "thoracic diaphragm meso-epithelium" EXACT [OBOL:automatic] synonym: "thoracic diaphragm mesothelium" EXACT [OBOL:automatic] xref: EMAPA:18429 is_a: UBERON:0001136 ! mesothelium is_a: UBERON:0004807 ! respiratory system epithelium intersection_of: UBERON:0001136 ! mesothelium intersection_of: BFO:0000050 UBERON:0001103 ! part of diaphragm relationship: BFO:0000050 UBERON:0001103 ! part of diaphragm property_value: skos:prefLabel "mesothelium of diaphragm" xsd:string [Term] id: UBERON:0003390 name: mesothelium of pleural cavity def: "A mesothelium that is part of a pleural cavity [Automatically generated definition]." [OBOL:automatic] synonym: "meso-epithelium of pleural cavity" EXACT [OBOL:automatic] synonym: "mesothelium of pleura" EXACT [FMA:18148] synonym: "pleura" RELATED [EMAPA:16775] synonym: "pleural cavity meso-epithelium" EXACT [OBOL:automatic] synonym: "pleural cavity mesothelium" EXACT [OBOL:automatic] synonym: "pleural mesothelium" EXACT [EMAPA:16775] xref: BTO:0003155 xref: EHDAA2:0001476 xref: EMAPA:16775 xref: FMA:18148 is_a: UBERON:0001136 ! mesothelium intersection_of: UBERON:0001136 ! mesothelium intersection_of: RO:0001025 UBERON:0002402 ! located in pleural cavity relationship: RO:0001025 UBERON:0002402 ! located in pleural cavity property_value: skos:prefLabel "mesothelium of pleural cavity" xsd:string [Term] id: UBERON:0003393 name: mesentery of urinary system def: "A mesentery that is part of a urinary system [Automatically generated definition]." [OBOL:automatic] synonym: "excretory system mesentery" EXACT [OBOL:automatic] synonym: "mesentery of excretory system" EXACT [OBOL:automatic] synonym: "mesentery of renal system" EXACT [OBOL:automatic] synonym: "mesentery of systema urinaria" EXACT [OBOL:automatic] synonym: "renal system mesentery" EXACT [OBOL:automatic] synonym: "systema urinaria mesentery" EXACT [OBOL:automatic] synonym: "urinary system mesentery" EXACT [OBOL:automatic] xref: EMAPA:17367 xref: MA:0003233 is_a: UBERON:0002095 ! mesentery intersection_of: UBERON:0002095 ! mesentery intersection_of: BFO:0000050 UBERON:0001008 ! part of renal system relationship: BFO:0000050 UBERON:0001008 ! part of renal system [Term] id: UBERON:0003394 name: mesentery of hindgut def: "A mesentery that is part of a hindgut [Automatically generated definition]." [OBOL:automatic] synonym: "hindgut mesentery" EXACT [OBOL:automatic] xref: EMAPA:16718 is_a: UBERON:0002095 ! mesentery intersection_of: UBERON:0002095 ! mesentery intersection_of: BFO:0000050 UBERON:0001046 ! part of hindgut relationship: BFO:0000050 UBERON:0001046 ! part of hindgut [Term] id: UBERON:0003395 name: mesentery of rectum def: "A mesentery that is part of a rectum [Automatically generated definition]." [OBOL:automatic] synonym: "rectum mesentery" EXACT [OBOL:automatic] xref: EMAPA:18664 is_a: UBERON:0003334 ! serosa of rectum is_a: UBERON:0004854 ! gastrointestinal system mesentery intersection_of: UBERON:0002095 ! mesentery intersection_of: BFO:0000050 UBERON:0001052 ! part of rectum [Term] id: UBERON:0003396 name: mesentery of colon def: "A mesentery that is part of a colon [Automatically generated definition]." [OBOL:automatic] synonym: "colon mesentery" EXACT [OBOL:automatic] synonym: "large bowel mesentery" EXACT [OBOL:automatic] synonym: "large intestinal mesentery" EXACT [FMA:14645] synonym: "mesentery of large bowel" EXACT [OBOL:automatic] synonym: "mesentery of large intestine" EXACT [FMA:14645] synonym: "mesocolon" EXACT [https://github.com/obophenotype/uberon/issues/1473] xref: EMAPA:18942 xref: FMA:14645 xref: SCTID:245457004 is_a: UBERON:0003335 ! serosa of colon is_a: UBERON:0004854 ! gastrointestinal system mesentery is_a: UBERON:0007826 {source="FMA"} ! peritoneal mesentery intersection_of: UBERON:0002095 ! mesentery intersection_of: BFO:0000050 UBERON:0001155 ! part of colon [Term] id: UBERON:0003397 name: mesentery of duodenum def: "A mesentery that is part of a duodenum [Automatically generated definition]." [OBOL:automatic] synonym: "duodenum mesentery" EXACT [OBOL:automatic] xref: EMAPA:19081 is_a: UBERON:0001170 ! mesentery of small intestine is_a: UBERON:0003336 ! serosa of duodenum intersection_of: UBERON:0002095 ! mesentery intersection_of: BFO:0000050 UBERON:0002114 ! part of duodenum [Term] id: UBERON:0003398 name: mesentery of jejunum def: "A mesentery that is part of a jejunum [Automatically generated definition]." [OBOL:automatic] synonym: "jejunal mesentery" EXACT [] synonym: "jejunum mesentery" EXACT [] synonym: "mesojejunum" EXACT [http://www.vivo.colostate.edu/hbooks/pathphys/misc_topics/peritoneum.html] xref: EMAPA:18670 xref: FMA:14651 xref: SCTID:261286003 is_a: UBERON:0001170 ! mesentery of small intestine is_a: UBERON:0003337 ! serosa of jejunum intersection_of: UBERON:0002095 ! mesentery intersection_of: BFO:0000050 UBERON:0002115 ! part of jejunum [Term] id: UBERON:0003403 name: skin of forearm def: "A zone of skin that is part of a lower arm [Automatically generated definition]." [OBOL:automatic] synonym: "forearm skin" EXACT [FMA:38265] synonym: "lower arm skin" EXACT [OBOL:automatic] synonym: "lower segment of arm skin" EXACT [OBOL:automatic] synonym: "skin of antebrachial region" EXACT [OBOL:automatic] synonym: "skin of lower arm" EXACT [OBOL:automatic] synonym: "skin of lower segment of arm" EXACT [OBOL:automatic] synonym: "skin of zeugopod of arm" EXACT [OBOL:automatic] xref: EMAPA:18056 xref: FMA:38265 xref: MA:0000602 xref: SCTID:181537008 is_a: UBERON:0002427 ! arm skin intersection_of: UBERON:0000014 ! zone of skin intersection_of: BFO:0000050 UBERON:0002386 ! part of forelimb zeugopod relationship: BFO:0000050 UBERON:0002386 ! part of forelimb zeugopod [Term] id: UBERON:0003404 name: lobar bronchus of right lung def: "A lobar bronchus that is part of a right lung [Automatically generated definition]." [OBOL:automatic] synonym: "right lobar bronchus" EXACT [OBOL:automatic] synonym: "right lung lobar bronchus" EXACT [OBOL:automatic] synonym: "right lung secondary bronchus" EXACT [OBOL:automatic] synonym: "secondary bronchus of right lung" EXACT [OBOL:automatic] xref: EMAPA:17664 xref: MA:0003134 xref: SCTID:245511004 is_a: UBERON:0002183 ! lobar bronchus intersection_of: UBERON:0002183 ! lobar bronchus intersection_of: BFO:0000050 UBERON:0002167 ! part of right lung relationship: BFO:0000050 UBERON:0006518 {is_inferred="true", source="https://github.com/obophenotype/uberon/wiki/Inferring-part-of-relationships"} ! part of right lung lobe property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/lung-female/v1.4/assets/3d-vh-f-lung.glb" xsd:anyURI property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/lung-male/v1.4/assets/3d-vh-m-lung.glb" xsd:anyURI [Term] id: UBERON:0003405 name: lobar bronchus of left lung def: "A lobar bronchus that is part of a left lung [Automatically generated definition]." [OBOL:automatic] synonym: "left lobar bronchus" EXACT [OBOL:automatic] synonym: "left lung lobar bronchus" EXACT [OBOL:automatic] synonym: "left lung secondary bronchus" EXACT [OBOL:automatic] synonym: "secondary bronchus of left lung" EXACT [OBOL:automatic] xref: EMAPA:17388 xref: EMAPA:17656 xref: MA:0003133 xref: SCTID:245510003 is_a: UBERON:0002183 ! lobar bronchus intersection_of: UBERON:0002183 ! lobar bronchus intersection_of: BFO:0000050 UBERON:0002168 ! part of left lung relationship: BFO:0000050 UBERON:0008951 {is_inferred="true", source="https://github.com/obophenotype/uberon/wiki/Inferring-part-of-relationships"} ! part of left lung lobe property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/lung-female/v1.4/assets/3d-vh-f-lung.glb" xsd:anyURI property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/lung-male/v1.4/assets/3d-vh-m-lung.glb" xsd:anyURI [Term] id: UBERON:0003406 name: cartilage of respiratory system def: "A cartilage element that is part of a respiratory system [Automatically generated definition]." [OBOL:automatic] synonym: "apparatus respiratorius cartilage" EXACT [OBOL:automatic] synonym: "cartilage of apparatus respiratorius" EXACT [OBOL:automatic] synonym: "respiratory system cartilage" EXACT [OBOL:automatic] xref: EMAPA:18694 xref: MA:0001818 is_a: UBERON:0007844 ! cartilage element intersection_of: UBERON:0007844 ! cartilage element intersection_of: BFO:0000050 UBERON:0001004 ! part of respiratory system relationship: BFO:0000050 UBERON:0001004 ! part of respiratory system property_value: skos:prefLabel "cartilage of respiratory system" xsd:string [Term] id: UBERON:0003408 name: gland of digestive tract def: "A gland that is part of a digestive tract [Automatically generated definition]." [OBOL:automatic] synonym: "digestive tract gland" EXACT [OBOL:automatic] synonym: "gland of digestive tract" EXACT [OBOL:automatic] synonym: "gland of lower gastrointestinal tract" EXACT [OBOL:automatic] synonym: "gut gland" EXACT [MA:0003202] synonym: "lower gastrointestinal tract gland" EXACT [OBOL:automatic] xref: EMAPA:18815 xref: MA:0003202 is_a: UBERON:0002530 ! gland is_a: UBERON:0013765 ! digestive system element intersection_of: UBERON:0002530 ! gland intersection_of: BFO:0000050 UBERON:0001555 ! part of digestive tract relationship: BFO:0000050 UBERON:0001555 ! part of digestive tract property_value: skos:prefLabel "gland of digestive tract" xsd:string [Term] id: UBERON:0003409 name: gland of tongue def: "Any of the mucous, serous, or mixed glands that empty their secretions onto the surface of the tongue." [http://www.merriam-webster.com/medical/lingual%20gland] subset: human_reference_atlas synonym: "lingual gland" EXACT [OBOL:automatic] synonym: "tongue gland" EXACT [OBOL:automatic] xref: EMAPA:25097 is_a: UBERON:0010047 ! oral gland intersection_of: UBERON:0002530 ! gland intersection_of: BFO:0000050 UBERON:0001723 ! part of tongue relationship: BFO:0000050 UBERON:0001723 ! part of tongue property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "gland of tongue" xsd:string [Term] id: UBERON:0003412 name: pelvic appendage bud mesenchyme def: "Mesenchyme that is part of a pelvic appendage bud." [OBOL:automatic] synonym: "hindlimb bud mesenchyme" NARROW SENSU [EMAPA:16781] synonym: "leg mesenchyme" EXACT [OBOL:automatic] synonym: "lower limb bud mesenchyme" EXACT [EHDAA2:0001035] synonym: "mesoderm pelvic fin bud" NARROW SENSU [ZFA:0001386] synonym: "pelvic fin bud mesenchyme" NARROW SENSU [] xref: EHDAA2:0001035 xref: EMAPA:16781 xref: TAO:0001386 xref: ZFA:0001386 is_a: UBERON:0010329 ! paired limb/fin bud mesenchyme intersection_of: UBERON:0003104 ! mesenchyme intersection_of: BFO:0000050 UBERON:0005420 ! part of pelvic appendage bud relationship: BFO:0000050 UBERON:0005420 ! part of pelvic appendage bud relationship: RO:0002202 UBERON:0005730 ! develops from pelvic appendage field [Term] id: UBERON:0003413 name: pectoral appendage bud mesenchyme def: "Mesenchyme that is part of a pectoral appendage bud." [OBOL:automatic] synonym: "arm mesenchyme" NARROW [OBOL:automatic] synonym: "forelimb bud mesenchyme" NARROW SENSU [EMAPA:16408] synonym: "mesoderm pectoral fin bud" NARROW SENSU [ZFA:0000789] synonym: "pectoral fin bud mesenchyme" NARROW SENSU [] synonym: "upper limb bud mesenchyme" NARROW [EHDAA2:0002135] synonym: "wing mesenchyme" NARROW [OBOL:automatic] xref: EHDAA2:0002135 xref: EHDAA:1703 xref: EMAPA:16408 xref: TAO:0000789 xref: ZFA:0000789 is_a: UBERON:0010329 ! paired limb/fin bud mesenchyme intersection_of: UBERON:0003104 ! mesenchyme intersection_of: BFO:0000050 UBERON:0005419 ! part of pectoral appendage bud relationship: BFO:0000050 UBERON:0005419 ! part of pectoral appendage bud relationship: RO:0002202 UBERON:0005729 ! develops from pectoral appendage field property_value: skos:prefLabel "pectoral appendage bud mesenchyme" xsd:string [Term] id: UBERON:0003416 name: mesenchyme of tongue def: "Mesenchyme that is part of a developing tongue [Automatically generated definition]." [OBOL:automatic] subset: human_reference_atlas synonym: "tongue mesenchyme" EXACT [EHDAA2:0004614] xref: EHDAA2:0004614 xref: EMAPA:17882 is_a: UBERON:0003104 ! mesenchyme intersection_of: UBERON:0003104 ! mesenchyme intersection_of: BFO:0000050 UBERON:0001723 ! part of tongue relationship: BFO:0000050 UBERON:0001723 ! part of tongue property_value: IAO:0000116 "TODO - develops_from" xsd:string property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "mesenchyme of tongue" xsd:string [Term] id: UBERON:0003418 name: mesenchyme of submandibular gland def: "Mesenchyme that is part of a developing submandibular gland [Automatically generated definition]." [OBOL:automatic] subset: human_reference_atlas synonym: "submandibular gland mesenchyme" EXACT [OBOL:automatic] synonym: "submaxillary gland mesenchyme" RELATED [EMAPA:18814] xref: EMAPA:18814 xref: VHOG:0001110 is_a: UBERON:0003324 ! mesenchyme of lower jaw intersection_of: UBERON:0003104 ! mesenchyme intersection_of: BFO:0000050 UBERON:0001736 ! part of submandibular gland relationship: BFO:0000050 UBERON:0001736 ! part of submandibular gland property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0003419 name: mesenchyme of parotid def: "Mesenchyme that is part of a developing parotid gland [Automatically generated definition]." [OBOL:automatic] subset: human_reference_atlas synonym: "mesenchyme of parotid gland" EXACT [OBOL:automatic] synonym: "parotid gland mesenchyme" EXACT [OBOL:automatic] synonym: "parotid mesenchyme" EXACT [OBOL:automatic] xref: EMAPA:18539 xref: VHOG:0001435 is_a: UBERON:0003324 ! mesenchyme of lower jaw is_a: UBERON:0009891 ! facial mesenchyme intersection_of: UBERON:0003104 ! mesenchyme intersection_of: BFO:0000050 UBERON:0001831 ! part of parotid gland relationship: BFO:0000050 UBERON:0001831 ! part of parotid gland property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0003420 name: mesenchyme of sublingual gland def: "Mesenchyme that is part of a developing sublingual gland [Automatically generated definition]." [OBOL:automatic] subset: human_reference_atlas synonym: "ductus sublingualis mesenchyme" EXACT [OBOL:automatic] synonym: "mesenchyme of ductus sublingualis" EXACT [OBOL:automatic] synonym: "mesenchyme of Rivinus'gland" EXACT [OBOL:automatic] synonym: "Rivinus'gland mesenchyme" EXACT [OBOL:automatic] synonym: "sublingual gland mesenchyme" EXACT [OBOL:automatic] xref: EMAPA:18811 xref: VHOG:0001106 is_a: UBERON:0003104 ! mesenchyme intersection_of: UBERON:0003104 ! mesenchyme intersection_of: BFO:0000050 UBERON:0001832 ! part of sublingual gland relationship: BFO:0000050 UBERON:0001832 ! part of sublingual gland property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0003421 name: mesenchyme of vomeronasal organ def: "Mesenchyme that is part of a developing vomeronasal organ [Automatically generated definition]." [OBOL:automatic] synonym: "Jacobson's organ mesenchyme" EXACT [OBOL:automatic] synonym: "mesenchyme of Jacobson's organ" EXACT [OBOL:automatic] synonym: "vomeronasal mesenchyme" EXACT [EHDAA2:0004103] synonym: "vomeronasal organ mesenchyme" EXACT [OBOL:automatic] xref: EHDAA2:0004103 xref: EMAPA:18445 is_a: UBERON:0007213 ! mesenchyme derived from head neural crest is_a: UBERON:0009891 ! facial mesenchyme intersection_of: UBERON:0003104 ! mesenchyme intersection_of: BFO:0000050 UBERON:0002255 ! part of vomeronasal organ relationship: BFO:0000050 UBERON:0002255 {source="EHDAA2"} ! part of vomeronasal organ relationship: RO:0002202 UBERON:0009204 {source="EHDAA2"} ! develops from medial nasal process mesenchyme [Term] id: UBERON:0003422 name: mesenchyme of umbilical cord def: "A gelatinous substance within the umbilical cord, largely made up of mucopolysaccharides (hyaluronic acid and chondroitin sulfate). It also contains some fibroblasts and macrophages. It is derived from Extra Embryonic Mesoderm[WP]." [Wikipedia:Wharton's_jelly] subset: human_reference_atlas synonym: "umbilical cord mesenchyme" EXACT [OBOL:automatic] synonym: "Wharton's jelly" EXACT [EMAPA:26127] xref: EMAPA:26127 xref: EMAPA:35925 xref: SCTID:368069009 xref: Wikipedia:Wharton's_jelly is_a: UBERON:0003104 ! mesenchyme is_a: UBERON:0005292 ! extraembryonic tissue intersection_of: UBERON:0003104 ! mesenchyme intersection_of: BFO:0000050 UBERON:0002331 ! part of umbilical cord relationship: BFO:0000050 UBERON:0002331 ! part of umbilical cord relationship: BFO:0000051 CHEBI:37395 {source="Wikipedia"} ! has part property_value: IAO:0000116 "TODO - check" xsd:string property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0003425 name: renal lymph node def: "A lymph node that is located in a kidney [Automatically generated definition]." [OBOL:automatic] synonym: "kidney lymph node" EXACT [OBOL:automatic] synonym: "lymph node of kidney" EXACT [OBOL:automatic] synonym: "para-renal lymph node" BROAD [PMID:22740822] synonym: "pararenal lymph node" BROAD [PMID:28346247] synonym: "perirenal lymph node" BROAD [PMID:35764904] xref: FMA:276799 xref: MA:0002882 xref: NCIT:C77646 xref: UMLS:C2699031 {source="ncithesaurus:Renal_Lymph_Node"} is_a: UBERON:0000029 ! lymph node intersection_of: UBERON:0000029 ! lymph node intersection_of: RO:0001025 UBERON:0002113 ! located in kidney relationship: RO:0001025 UBERON:0002113 ! located in kidney [Term] id: UBERON:0003426 name: dermis adipose tissue def: "An adipose tissue that is part of a dermis [Automatically generated definition]." [OBOL:automatic] subset: pheno_slim synonym: "adipose tissue of dermis" EXACT [OBOL:automatic] synonym: "dermis fat tissue" EXACT [OBOL:automatic] synonym: "dermis fatty tissue" EXACT [OBOL:automatic] synonym: "fat tissue of dermis" EXACT [OBOL:automatic] synonym: "fatty tissue of dermis" EXACT [OBOL:automatic] xref: MA:0000798 is_a: UBERON:0001013 ! adipose tissue is_a: UBERON:0003585 ! dermis connective tissue intersection_of: UBERON:0001013 ! adipose tissue intersection_of: BFO:0000050 UBERON:0002067 ! part of dermis property_value: skos:prefLabel "dermis adipose tissue" xsd:string [Term] id: UBERON:0003429 name: abdomen nerve def: "A nerve that is part of an abdomen [Automatically generated definition]." [OBOL:automatic] synonym: "nerve of abdomen" EXACT [OBOL:automatic] xref: MA:0000521 is_a: UBERON:0003825 ! nerve of abdominal segment intersection_of: UBERON:0001021 ! nerve intersection_of: BFO:0000050 UBERON:0000916 ! part of abdomen relationship: BFO:0000050 UBERON:0000916 ! part of abdomen property_value: skos:prefLabel "abdomen nerve" xsd:string [Term] id: UBERON:0003430 name: neck nerve def: "A nerve that is part of a neck [Automatically generated definition]." [OBOL:automatic] synonym: "neck (volume) nerve" EXACT [OBOL:automatic] synonym: "nerve of neck" EXACT [OBOL:automatic] synonym: "nerve of neck (volume)" EXACT [OBOL:automatic] xref: EMAPA:37263 {source="MA:th"} xref: MA:0000588 is_a: UBERON:0001021 ! nerve intersection_of: UBERON:0001021 ! nerve intersection_of: BFO:0000050 UBERON:0000974 ! part of neck relationship: BFO:0000050 UBERON:0000974 ! part of neck property_value: skos:prefLabel "neck nerve" xsd:string [Term] id: UBERON:0003431 name: leg nerve def: "A nerve that is part of a leg [Automatically generated definition]." [OBOL:automatic] synonym: "nerve of leg" EXACT [OBOL:automatic] xref: EMAPA:37343 {source="MA:th"} xref: MA:0000673 is_a: UBERON:0003442 ! hindlimb nerve intersection_of: UBERON:0001021 ! nerve intersection_of: BFO:0000050 UBERON:0000978 ! part of leg relationship: BFO:0000050 UBERON:0000978 ! part of leg [Term] id: UBERON:0003432 name: chest nerve def: "A nerve that is part of a chest [Automatically generated definition]." [OBOL:automatic] synonym: "anterior thoracic region nerve" EXACT [OBOL:automatic] synonym: "anterolateral part of thorax nerve" EXACT [OBOL:automatic] synonym: "front of thorax nerve" EXACT [OBOL:automatic] synonym: "nerve of anterior thoracic region" EXACT [OBOL:automatic] synonym: "nerve of anterolateral part of thorax" EXACT [OBOL:automatic] synonym: "nerve of chest" EXACT [OBOL:automatic] synonym: "nerve of front of thorax" EXACT [OBOL:automatic] xref: EMAPA:37266 {source="MA:th"} xref: MA:0000551 is_a: UBERON:0003824 ! nerve of thoracic segment intersection_of: UBERON:0001021 ! nerve intersection_of: BFO:0000050 UBERON:0001443 ! part of chest relationship: BFO:0000050 UBERON:0001443 ! part of chest [Term] id: UBERON:0003433 name: arm nerve def: "A nerve that is part of an arm [Automatically generated definition]." [OBOL:automatic] synonym: "brachial region nerve" EXACT [OBOL:automatic] synonym: "nerve of arm" EXACT [OBOL:automatic] synonym: "nerve of brachial region" EXACT [OBOL:automatic] xref: EMAPA:37336 {source="MA:th"} xref: MA:0000595 is_a: UBERON:0003441 ! forelimb nerve intersection_of: UBERON:0001021 ! nerve intersection_of: BFO:0000050 UBERON:0001460 ! part of arm relationship: BFO:0000050 UBERON:0001460 ! part of arm [Term] id: UBERON:0003434 name: wrist nerve def: "A nerve that is part of a wrist [Automatically generated definition]." [OBOL:automatic] synonym: "carpal region nerve" EXACT [OBOL:automatic] synonym: "nerve of carpal region" EXACT [OBOL:automatic] synonym: "nerve of wrist" EXACT [OBOL:automatic] xref: EMAPA:37339 {source="MA:th"} xref: MA:0000637 is_a: UBERON:0003448 ! manus nerve intersection_of: UBERON:0001021 ! nerve intersection_of: BFO:0000050 UBERON:0004452 ! part of carpal region relationship: BFO:0000050 UBERON:0004452 ! part of carpal region [Term] id: UBERON:0003435 name: pedal digit nerve def: "A nerve that is part of a toe [Automatically generated definition]." [OBOL:automatic] synonym: "digit of foot nerve" EXACT [OBOL:automatic] synonym: "digit of terminal segment of free lower limb nerve" EXACT [OBOL:automatic] synonym: "digitus pedis nerve" EXACT [OBOL:automatic] synonym: "foot digit nerve" EXACT [MA:0000649] synonym: "foot digit nerve" NARROW SENSU [NCBITaxon:9606, OBOL:accepted] synonym: "hind limb digit nerve" EXACT [OBOL:accepted] synonym: "nerve of digit of foot" EXACT [OBOL:automatic] synonym: "nerve of digit of terminal segment of free lower limb" EXACT [OBOL:automatic] synonym: "nerve of digitus pedis" EXACT [OBOL:automatic] synonym: "nerve of foot digit" EXACT [OBOL:automatic] synonym: "nerve of terminal segment of free lower limb digit" EXACT [OBOL:automatic] synonym: "nerve of toe" EXACT [OBOL:automatic] synonym: "terminal segment of free lower limb digit nerve" EXACT [OBOL:automatic] synonym: "toe nerve" EXACT [OBOL:automatic] xref: EMAPA:37348 {source="MA:th"} xref: MA:0000649 xref: SCTID:300056004 is_a: UBERON:0003445 ! pes nerve intersection_of: UBERON:0001021 ! nerve intersection_of: BFO:0000050 UBERON:0001466 ! part of pedal digit relationship: BFO:0000050 UBERON:0001466 ! part of pedal digit [Term] id: UBERON:0003436 name: shoulder nerve def: "A nerve that is part of a shoulder [Automatically generated definition]." [OBOL:automatic] synonym: "nerve of shoulder" EXACT [OBOL:automatic] xref: EMAPA:37335 {source="MA:th"} xref: MA:0000634 is_a: UBERON:0001021 ! nerve intersection_of: UBERON:0001021 ! nerve intersection_of: BFO:0000050 UBERON:0001467 ! part of shoulder relationship: BFO:0000050 UBERON:0001467 ! part of shoulder [Term] id: UBERON:0003437 name: eyelid nerve def: "A nerve that innervates an eyelid." [http://orcid.org/0000-0002-6601-2165] synonym: "blepharon nerve" EXACT [OBOL:automatic] synonym: "nerve of blepharon" EXACT [OBOL:automatic] synonym: "nerve of eyelid" EXACT [OBOL:automatic] synonym: "palpebral nerve" EXACT [OBOL:automatic] xref: EMAPA:37535 {source="MA:th"} xref: MA:0001255 is_a: UBERON:0001021 ! nerve intersection_of: UBERON:0001021 ! nerve intersection_of: RO:0002134 UBERON:0001711 ! innervates eyelid relationship: RO:0002134 UBERON:0001711 ! innervates eyelid [Term] id: UBERON:0003438 name: iris nerve def: "Any nerve that innervates the iris." [UBERON:cjm] synonym: "ciliary nerve" NARROW [] synonym: "nerve of iris" EXACT [OBOL:automatic] xref: EMAPA:35449 xref: MA:0001291 is_a: UBERON:0001021 ! nerve intersection_of: UBERON:0001021 ! nerve intersection_of: RO:0002134 UBERON:0001769 ! innervates iris relationship: RO:0002134 UBERON:0001769 ! innervates iris property_value: IAO:0000116 "added for consistency with mouse ontologies. The term 'ciliary nerve' is usually used to denote either of the two nerves (with different origins) that innervate the iris, as well as ciliary muscles and cornea" xsd:string property_value: skos:prefLabel "iris nerve" xsd:string [Term] id: UBERON:0003439 name: nerve of trunk region def: "A nerve that is part of the trunk region of the body (not to be confused with a nerve trunk)." [http://orcid.org/0000-0002-6601-2165] subset: grouping_class subset: non_informative synonym: "nerve of torso" EXACT [OBOL:automatic] synonym: "nerve of trunk" EXACT [OBOL:automatic] synonym: "torso nerve" EXACT [OBOL:automatic] synonym: "trunk nerve" RELATED [MA:0000515] xref: EMAPA:37264 {source="MA:th"} xref: MA:0000515 is_a: UBERON:0001021 ! nerve intersection_of: UBERON:0001021 ! nerve intersection_of: BFO:0000050 UBERON:0002100 ! part of trunk relationship: BFO:0000050 UBERON:0002100 ! part of trunk property_value: skos:prefLabel "nerve of trunk region" xsd:string [Term] id: UBERON:0003440 name: limb nerve def: "A nerve that is part of a limb [Automatically generated definition]." [OBOL:automatic] synonym: "nerve of limb" EXACT [OBOL:automatic] xref: EMAPA:37291 {source="MA:th"} xref: MA:0000693 xref: SCTID:359923002 is_a: UBERON:0001021 ! nerve intersection_of: UBERON:0001021 ! nerve intersection_of: BFO:0000050 UBERON:0002101 ! part of limb relationship: BFO:0000050 UBERON:0002101 ! part of limb [Term] id: UBERON:0003441 name: forelimb nerve def: "A nerve that is part of a forelimb [Automatically generated definition]." [OBOL:automatic] synonym: "fore limb nerve" EXACT [OBOL:automatic] synonym: "nerve of fore limb" EXACT [OBOL:automatic] synonym: "nerve of forelimb" EXACT [OBOL:automatic] synonym: "nerve of superior member" EXACT [OBOL:automatic] synonym: "nerve of upper extremity" EXACT [OBOL:automatic] synonym: "wing nerve" NARROW SENSU [NCBITaxon:8782, OBOL:automatic] xref: EMAPA:37334 {source="MA:th"} xref: MA:0000616 is_a: UBERON:0003440 ! limb nerve intersection_of: UBERON:0001021 ! nerve intersection_of: BFO:0000050 UBERON:0002102 ! part of forelimb relationship: BFO:0000050 UBERON:0002102 ! part of forelimb [Term] id: UBERON:0003442 name: hindlimb nerve def: "A nerve that is part of a hindlimb [Automatically generated definition]." [OBOL:automatic] synonym: "hind limb nerve" EXACT [OBOL:automatic] synonym: "nerve of hind limb" EXACT [OBOL:automatic] synonym: "nerve of hindlimb" EXACT [OBOL:automatic] synonym: "nerve of inferior member" EXACT [OBOL:automatic] synonym: "nerve of lower extremity" EXACT [OBOL:automatic] xref: EMAPA:37342 {source="MA:th"} xref: MA:0000664 is_a: UBERON:0003440 ! limb nerve intersection_of: UBERON:0001021 ! nerve intersection_of: BFO:0000050 UBERON:0002103 ! part of hindlimb relationship: BFO:0000050 UBERON:0002103 ! part of hindlimb [Term] id: UBERON:0003443 name: thoracic cavity nerve def: "A nerve that is located in a thoracic cavity [Automatically generated definition]." [OBOL:automatic] synonym: "cavity of chest nerve" EXACT [OBOL:automatic] synonym: "cavity of thorax nerve" EXACT [OBOL:automatic] synonym: "chest cavity nerve" EXACT [OBOL:automatic] synonym: "nerve of cavity of chest" EXACT [OBOL:automatic] synonym: "nerve of cavity of thorax" EXACT [OBOL:automatic] synonym: "nerve of chest cavity" EXACT [OBOL:automatic] synonym: "nerve of pectoral cavity" EXACT [OBOL:automatic] synonym: "nerve of thoracic cavity" EXACT [OBOL:automatic] synonym: "pectoral cavity nerve" EXACT [OBOL:automatic] xref: EMAPA:37267 {source="MA:th"} xref: MA:0000556 is_a: UBERON:0001021 ! nerve intersection_of: UBERON:0001021 ! nerve intersection_of: RO:0001025 UBERON:0002224 ! located in thoracic cavity relationship: RO:0001025 UBERON:0002224 ! located in thoracic cavity property_value: IAO:0000116 "consider merging with thoracic nerve. In MA the only subclass is the phrenic nerve, which arises from a cervical nerve" xsd:string property_value: skos:prefLabel "thoracic cavity nerve" xsd:string [Term] id: UBERON:0003444 name: pelvis nerve def: "A nerve that is part of a pelvis [Automatically generated definition]." [OBOL:automatic] synonym: "nerve of pelvis" EXACT [OBOL:automatic] xref: EMAPA:37269 {source="MA:th"} xref: MA:0000542 is_a: UBERON:0003825 ! nerve of abdominal segment intersection_of: UBERON:0001021 ! nerve intersection_of: BFO:0000050 UBERON:0002355 ! part of pelvic region of trunk relationship: BFO:0000050 UBERON:0002355 ! part of pelvic region of trunk [Term] id: UBERON:0003445 name: pes nerve def: "A nerve that is part of a foot [Automatically generated definition]." [OBOL:automatic] synonym: "foot nerve" EXACT [MA:0000653] synonym: "nerve of foot" EXACT [OBOL:automatic] xref: EMAPA:37347 {source="MA:th"} xref: MA:0000653 is_a: UBERON:0003442 ! hindlimb nerve intersection_of: UBERON:0001021 ! nerve intersection_of: BFO:0000050 UBERON:0002387 ! part of pes relationship: BFO:0000050 UBERON:0002387 ! part of pes [Term] id: UBERON:0003446 name: ankle nerve def: "A nerve that is part of an ankle [Automatically generated definition]." [OBOL:automatic] synonym: "nerve of ankle" EXACT [OBOL:automatic] synonym: "neural network of ankle" RELATED [FMA:86901] synonym: "tarsal region nerve" EXACT [https://orcid.org/0000-0002-6601-2165] xref: EMAPA:37346 {source="MA:th"} xref: MA:0000640 is_a: UBERON:0003445 ! pes nerve intersection_of: UBERON:0001021 ! nerve intersection_of: BFO:0000050 UBERON:0004454 ! part of tarsal region relationship: BFO:0000050 UBERON:0004454 ! part of tarsal region property_value: seeAlso FMA:86901 [Term] id: UBERON:0003447 name: digit nerve of manus def: "A nerve that is part of a finger [Automatically generated definition]." [OBOL:automatic] synonym: "digit of hand nerve" EXACT [OBOL:automatic] synonym: "digit of terminal segment of free upper limb nerve" EXACT [OBOL:automatic] synonym: "digitus manus nerve" EXACT [OBOL:automatic] synonym: "finger nerve" EXACT [OBOL:automatic] synonym: "hand digit nerve" EXACT [MA:0000625] synonym: "nerve of digit of hand" EXACT [OBOL:automatic] synonym: "nerve of digit of terminal segment of free upper limb" EXACT [OBOL:automatic] synonym: "nerve of digitus manus" EXACT [OBOL:automatic] synonym: "nerve of finger" EXACT [OBOL:automatic] synonym: "nerve of hand digit" EXACT [OBOL:automatic] synonym: "nerve of terminal segment of free upper limb digit" EXACT [OBOL:automatic] synonym: "terminal segment of free upper limb digit nerve" EXACT [OBOL:automatic] xref: EMAPA:37341 {source="MA:th"} xref: MA:0000625 xref: SCTID:181015006 is_a: UBERON:0003448 ! manus nerve intersection_of: UBERON:0001021 ! nerve intersection_of: BFO:0000050 UBERON:0002389 ! part of manual digit relationship: BFO:0000050 UBERON:0002389 ! part of manual digit [Term] id: UBERON:0003448 name: manus nerve def: "A nerve that is part of a manus [Automatically generated definition]." [OBOL:automatic] synonym: "hand nerve" EXACT [MA:0000629] synonym: "nerve of hand" EXACT [UBERON:cjm] synonym: "nerve of manus" EXACT [OBOL:automatic] xref: EMAPA:37340 {source="MA:th"} xref: MA:0000629 is_a: UBERON:0003441 ! forelimb nerve intersection_of: UBERON:0001021 ! nerve intersection_of: BFO:0000050 UBERON:0002398 ! part of manus relationship: BFO:0000050 UBERON:0002398 ! part of manus [Term] id: UBERON:0003449 name: tail intervertebral disc def: "An intervertebral disk that is part of a tail [Automatically generated definition]." [OBOL:automatic] synonym: "intervertebral disc of post-ventral region" EXACT [UBERON:cjm] synonym: "intervertebral disc of tail" EXACT [OBOL:automatic] synonym: "intervertebral disk of post-ventral region" EXACT [OBOL:automatic] synonym: "intervertebral disk of tail" EXACT [OBOL:automatic] synonym: "tail intervertebral disk" EXACT [OBOL:automatic] synonym: "tail spinal disc" EXACT [OBOL:automatic] xref: EMAPA:19592 xref: MA:0000698 is_a: UBERON:0001066 ! intervertebral disk intersection_of: UBERON:0001066 ! intervertebral disk intersection_of: BFO:0000050 UBERON:0007812 ! part of post-anal tail relationship: BFO:0000050 UBERON:0007812 ! part of post-anal tail [Term] id: UBERON:0003452 name: trabecula carnea cardiac muscle tissue def: "A portion of cardiac muscle tissue that is part of a trabecula carnea [Automatically generated definition]." [OBOL:automatic] subset: pheno_slim synonym: "cardiac muscle muscle tissue of trabecula carnea" EXACT [OBOL:automatic] synonym: "cardiac muscle of trabecula carnea" EXACT [OBOL:automatic] synonym: "cardiac muscle textus muscularis of trabecula carnea" EXACT [OBOL:automatic] synonym: "cardiac muscle tissue of trabecula carnea" EXACT [OBOL:automatic] synonym: "heart muscle muscle tissue of trabecula carnea" EXACT [OBOL:automatic] synonym: "heart muscle textus muscularis of trabecula carnea" EXACT [OBOL:automatic] synonym: "heart myocardium muscle tissue of trabecula carnea" EXACT [OBOL:automatic] synonym: "heart myocardium textus muscularis of trabecula carnea" EXACT [OBOL:automatic] synonym: "muscle of heart muscle tissue of trabecula carnea" EXACT [OBOL:automatic] synonym: "muscle of heart textus muscularis of trabecula carnea" EXACT [OBOL:automatic] synonym: "muscle tissue of cardiac muscle of trabecula carnea" EXACT [OBOL:automatic] synonym: "muscle tissue of heart muscle of trabecula carnea" EXACT [OBOL:automatic] synonym: "muscle tissue of heart myocardium of trabecula carnea" EXACT [OBOL:automatic] synonym: "muscle tissue of muscle of heart of trabecula carnea" EXACT [OBOL:automatic] synonym: "muscle tissue of myocardium of trabecula carnea" EXACT [OBOL:automatic] synonym: "myocardium muscle tissue of trabecula carnea" EXACT [OBOL:automatic] synonym: "myocardium textus muscularis of trabecula carnea" EXACT [OBOL:automatic] synonym: "textus muscularis of cardiac muscle of trabecula carnea" EXACT [OBOL:automatic] synonym: "textus muscularis of heart muscle of trabecula carnea" EXACT [OBOL:automatic] synonym: "textus muscularis of heart myocardium of trabecula carnea" EXACT [OBOL:automatic] synonym: "textus muscularis of muscle of heart of trabecula carnea" EXACT [OBOL:automatic] synonym: "textus muscularis of myocardium of trabecula carnea" EXACT [OBOL:automatic] synonym: "trabecula carnea cardiac muscle" EXACT [OBOL:automatic] synonym: "trabecula carnea cardiac muscle muscle tissue" EXACT [OBOL:automatic] synonym: "trabecula carnea cardiac muscle textus muscularis" EXACT [OBOL:automatic] synonym: "trabecula carnea heart muscle muscle tissue" EXACT [OBOL:automatic] synonym: "trabecula carnea heart muscle textus muscularis" EXACT [OBOL:automatic] synonym: "trabecula carnea heart myocardium muscle tissue" EXACT [OBOL:automatic] synonym: "trabecula carnea heart myocardium textus muscularis" EXACT [OBOL:automatic] synonym: "trabecula carnea muscle of heart muscle tissue" EXACT [OBOL:automatic] synonym: "trabecula carnea muscle of heart textus muscularis" EXACT [OBOL:automatic] synonym: "trabecula carnea muscle tissue of cardiac muscle" EXACT [OBOL:automatic] synonym: "trabecula carnea muscle tissue of heart muscle" EXACT [OBOL:automatic] synonym: "trabecula carnea muscle tissue of heart myocardium" EXACT [OBOL:automatic] synonym: "trabecula carnea muscle tissue of muscle of heart" EXACT [OBOL:automatic] synonym: "trabecula carnea muscle tissue of myocardium" EXACT [OBOL:automatic] synonym: "trabecula carnea myocardium muscle tissue" EXACT [OBOL:automatic] synonym: "trabecula carnea myocardium textus muscularis" EXACT [OBOL:automatic] synonym: "trabecula carnea textus muscularis of cardiac muscle" EXACT [OBOL:automatic] synonym: "trabecula carnea textus muscularis of heart muscle" EXACT [OBOL:automatic] synonym: "trabecula carnea textus muscularis of heart myocardium" EXACT [OBOL:automatic] synonym: "trabecula carnea textus muscularis of muscle of heart" EXACT [OBOL:automatic] synonym: "trabecula carnea textus muscularis of myocardium" EXACT [OBOL:automatic] xref: EMAPA:36573 xref: FMA:84428 xref: MA:0002833 is_a: UBERON:0018649 ! cardiac muscle tissue of ventricle intersection_of: UBERON:0001133 ! cardiac muscle tissue intersection_of: BFO:0000050 UBERON:0002511 ! part of trabecula carnea relationship: BFO:0000050 UBERON:0002511 ! part of trabecula carnea [Term] id: UBERON:0003453 name: large intestine Peyer's patch def: "A Peyer's patch that is part of a large intestine." [OBOL:automatic] synonym: "large intestine Peyer's patch" EXACT [OBOL:automatic] synonym: "Peyer's patch of large intestine" EXACT [OBOL:automatic] synonym: "solitary lymphatic follicle of large intestine" RELATED [FMA:15658] synonym: "solitary lymphoid follicle of subdivision of large intestine" RELATED [FMA:15658] xref: EMAPA:35468 xref: FMA:15658 xref: MA:0001550 is_a: UBERON:0001211 ! Peyer's patch intersection_of: UBERON:0001211 ! Peyer's patch intersection_of: BFO:0000050 UBERON:0000059 ! part of large intestine relationship: BFO:0000050 UBERON:0000059 ! part of large intestine property_value: IAO:0000116 "requires expert attention" xsd:string [Term] id: UBERON:0003454 name: small intestine Peyer's patch def: "Nodular lymphoid structures on the serosal surface of the small intestine." [http://orcid.org/0000-0002-6601-2165] synonym: "aggregated lymphoid follicle of small intestine" EXACT [FMA:15054] synonym: "noduli lymphoidei aggregati intestini tenuis" EXACT OMO:0003011 [FMA:76466] synonym: "Peyer's patch" BROAD [FMA:15054] synonym: "Peyer's patch of small bowel" EXACT [OBOL:automatic] synonym: "Peyer's patch of small intestine" EXACT [OBOL:automatic] synonym: "small bowel Peyer's patch" EXACT [OBOL:automatic] synonym: "small intestine Peyer's patch" EXACT [OBOL:automatic] xref: EMAPA:35782 xref: FMA:15054 xref: MA:0001557 xref: SCTID:38986009 is_a: UBERON:0001211 ! Peyer's patch intersection_of: UBERON:0001211 ! Peyer's patch intersection_of: BFO:0000050 UBERON:0002108 ! part of small intestine relationship: BFO:0000050 UBERON:0001204 {source="ncithesaurus"} ! part of mucosa of small intestine property_value: IAO:0000116 "add subtypes for jejunum, ileum" xsd:string [Term] id: UBERON:0003455 name: inner renal medulla loop of Henle def: "A loop of Henle that is part of a inner medulla of kidney [Automatically generated definition]." [OBOL:automatic] synonym: "kidney inner medulla loop of Henle" EXACT [MA:0002623] synonym: "loop of Henle, inner medullary portion" EXACT [EMAPA:28352] xref: EMAPA:28352 xref: MA:0002623 is_a: UBERON:0034997 ! renal medulla loop of Henle intersection_of: UBERON:0001288 ! loop of Henle intersection_of: BFO:0000050 UBERON:0001294 ! part of inner medulla of kidney relationship: BFO:0000050 UBERON:0001294 ! part of inner medulla of kidney [Term] id: UBERON:0003456 name: respiratory system lymphatic vessel def: "A lymphatic vessel that is part of a respiratory system [Automatically generated definition]." [OBOL:automatic] synonym: "apparatus respiratorius lymph vessel" EXACT [OBOL:automatic] synonym: "apparatus respiratorius lymphatic vessel" EXACT [OBOL:automatic] synonym: "lymph vessel of apparatus respiratorius" EXACT [OBOL:automatic] synonym: "lymph vessel of respiratory system" EXACT [OBOL:automatic] synonym: "lymphatic vessel of apparatus respiratorius" EXACT [OBOL:automatic] synonym: "lymphatic vessel of respiratory system" EXACT [OBOL:automatic] synonym: "respiratory system lymph vessel" EXACT [OBOL:automatic] xref: EMAPA:37580 {source="MA:th"} xref: MA:0001824 is_a: UBERON:0001473 ! lymphatic vessel intersection_of: UBERON:0001473 ! lymphatic vessel intersection_of: BFO:0000050 UBERON:0001004 ! part of respiratory system relationship: BFO:0000050 UBERON:0001004 ! part of respiratory system [Term] id: UBERON:0003457 name: head bone def: "A bone that is part of a head [Automatically generated definition]." [OBOL:automatic] comment: Different sources vary regarding which bones are craniofacial; e.g. hyoid bone subset: pheno_slim synonym: "adult head bone" EXACT [OBOL:automatic] synonym: "adult head bone organ" EXACT [OBOL:automatic] synonym: "bone of adult head" EXACT [OBOL:automatic] synonym: "bone of head" EXACT [OBOL:automatic] synonym: "bone organ of adult head" EXACT [OBOL:automatic] synonym: "bone organ of head" EXACT [OBOL:automatic] synonym: "craniofacial bone" RELATED [http://orcid.org/0000-0002-6601-2165] synonym: "head bone organ" EXACT [OBOL:automatic] xref: EMAPA:35996 xref: MA:0000576 xref: SCTID:118646007 is_a: UBERON:0007914 ! bone of craniocervical region intersection_of: UBERON:0001474 ! bone element intersection_of: BFO:0000050 UBERON:0000033 ! part of head relationship: BFO:0000050 UBERON:0000033 ! part of head property_value: skos:prefLabel "head bone" xsd:string [Term] id: UBERON:0003458 name: neck bone def: "A bone that is part of a neck [Automatically generated definition]." [OBOL:automatic] synonym: "bone of neck" EXACT [OBOL:automatic] synonym: "bone of neck (volume)" EXACT [OBOL:automatic] synonym: "bone organ of neck" EXACT [OBOL:automatic] synonym: "bone organ of neck (volume)" EXACT [OBOL:automatic] synonym: "neck (volume) bone" EXACT [OBOL:automatic] synonym: "neck (volume) bone organ" EXACT [OBOL:automatic] synonym: "neck bone organ" EXACT [OBOL:automatic] xref: EMAPA:37246 {source="MA:th"} xref: MA:0000584 is_a: UBERON:0001474 ! bone element intersection_of: UBERON:0001474 ! bone element intersection_of: BFO:0000050 UBERON:0000974 ! part of neck relationship: BFO:0000050 UBERON:0000974 ! part of neck property_value: skos:prefLabel "neck bone" xsd:string [Term] id: UBERON:0003459 name: chest bone def: "A bone that is part of a chest [Automatically generated definition]." [OBOL:automatic] synonym: "anterior thoracic region bone" EXACT [OBOL:automatic] synonym: "anterior thoracic region bone organ" EXACT [OBOL:automatic] synonym: "anterolateral part of thorax bone" EXACT [OBOL:automatic] synonym: "anterolateral part of thorax bone organ" EXACT [OBOL:automatic] synonym: "bone of anterior thoracic region" EXACT [OBOL:automatic] synonym: "bone of anterolateral part of thorax" EXACT [OBOL:automatic] synonym: "bone of chest" EXACT [OBOL:automatic] synonym: "bone of front of thorax" EXACT [OBOL:automatic] synonym: "bone organ of anterior thoracic region" EXACT [OBOL:automatic] synonym: "bone organ of anterolateral part of thorax" EXACT [OBOL:automatic] synonym: "bone organ of chest" EXACT [OBOL:automatic] synonym: "bone organ of front of thorax" EXACT [OBOL:automatic] synonym: "chest bone organ" EXACT [OBOL:automatic] synonym: "front of thorax bone" EXACT [OBOL:automatic] synonym: "front of thorax bone organ" EXACT [OBOL:automatic] xref: EMAPA:18025 xref: MA:0000547 is_a: UBERON:0003827 ! thoracic segment bone is_a: UBERON:0005175 ! chest organ intersection_of: UBERON:0001474 ! bone element intersection_of: BFO:0000050 UBERON:0001443 ! part of chest [Term] id: UBERON:0003460 name: arm bone def: "A bone that is part of the region of the forelimb that includes the zeugopod and stylopod. Examples: patella, femur, tibia." [https://orcid.org/0000-0002-6601-2165] subset: human_reference_atlas synonym: "arm bone organ" EXACT [OBOL:automatic] synonym: "bone of arm" EXACT [OBOL:automatic] synonym: "bone of upper extremity" RELATED [GAID:178] synonym: "bone organ of arm" EXACT [OBOL:automatic] xref: EMAPA:37303 {source="MA:th"} xref: MA:0000592 is_a: UBERON:0008962 ! forelimb bone intersection_of: UBERON:0001474 ! bone element intersection_of: BFO:0000050 UBERON:0001460 ! part of arm relationship: BFO:0000050 UBERON:0001460 ! part of arm property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0003461 name: shoulder bone def: "A bone that is connected via a shoulder joint (i.e. glenohumeral or acromioclavicular joints). The shoulder bones are the clavicle, scapula and humerus - but note that these are only considered to be shoulder bones when a true shoulder is present, as in most tetrapods." [http://orcid.org/0000-0002-6601-2165] subset: pheno_slim synonym: "bone of shoulder" EXACT [OBOL:automatic] synonym: "shoulder-articulating bone" EXACT [] xref: MA:0000631 is_a: UBERON:0010741 ! bone of pectoral complex intersection_of: UBERON:0001474 ! bone element intersection_of: RO:0002131 UBERON:0016884 ! overlaps shoulder joint relationship: BFO:0000050 UBERON:0012475 ! part of skeleton of pectoral complex relationship: RO:0002131 UBERON:0016884 ! overlaps shoulder joint [Term] id: UBERON:0003462 name: facial bone def: "A bone that is part of a facial skeleton [Automatically generated definition]." [OBOL:automatic] subset: pheno_slim synonym: "bone of facial skeleton" EXACT [OBOL:automatic] synonym: "bone of viscerocranium" RELATED [OBOL:automatic] synonym: "facial bone" EXACT [EMAPA:19019] synonym: "facial skeleton bone" EXACT [OBOL:automatic] synonym: "viscerocranium bone" RELATED [OBOL:automatic] xref: EMAPA:19019 xref: EMAPA:35924 xref: MA:0001482 xref: MA:0003159 xref: NCIT:C63706 xref: SCTID:181799005 xref: UMLS:C0015455 {source="ncithesaurus:Facial_Bone"} is_a: UBERON:0003457 ! head bone intersection_of: UBERON:0001474 ! bone element intersection_of: BFO:0000050 UBERON:0011156 ! part of facial skeleton relationship: BFO:0000050 UBERON:0011156 {source="MA"} ! part of facial skeleton property_value: IAO:0000116 "test whether 'facial bone' is an exact synonym" xsd:string property_value: skos:prefLabel "facial bone" xsd:string [Term] id: UBERON:0003463 name: trunk bone def: "A bone that is part of a trunk [Automatically generated definition]." [OBOL:automatic] synonym: "bone of torso" EXACT [OBOL:automatic] synonym: "bone of trunk" EXACT [OBOL:automatic] synonym: "bone organ of torso" EXACT [OBOL:automatic] synonym: "bone organ of trunk" EXACT [OBOL:automatic] synonym: "torso bone" EXACT [OBOL:automatic] synonym: "torso bone organ" EXACT [OBOL:automatic] synonym: "trunk bone organ" EXACT [OBOL:automatic] xref: EMAPA:36583 xref: MA:0000512 xref: SCTID:427358002 is_a: UBERON:0001474 ! bone element is_a: UBERON:0005177 ! trunk region element intersection_of: UBERON:0001474 ! bone element intersection_of: BFO:0000050 UBERON:0002100 ! part of trunk property_value: skos:prefLabel "trunk bone" xsd:string [Term] id: UBERON:0003464 name: hindlimb bone def: "A bone that is part of a hindlimb region. Examples: any pes phalanx, femur. Counter-examples: ischium, pubis (they are part of the pelvic girdle)." [https://orcid.org/0000-0002-6601-2165] subset: efo_slim synonym: "bone of hind limb" EXACT [OBOL:automatic] synonym: "bone of hindlimb" EXACT [OBOL:automatic] synonym: "bone of inferior member" EXACT [OBOL:automatic] synonym: "bone of lower extremity" EXACT [OBOL:automatic] synonym: "bone organ of hind limb" EXACT [OBOL:automatic] synonym: "bone organ of hindlimb" EXACT [OBOL:automatic] synonym: "bone organ of lower extremity" EXACT [OBOL:automatic] synonym: "hind limb bone" EXACT [OBOL:automatic] synonym: "hind limb bone organ" EXACT [OBOL:automatic] synonym: "hindlimb bone organ" EXACT [OBOL:automatic] xref: EFO:0003842 xref: GAID:198 xref: NCIT:C12982 xref: SCTID:361370006 xref: UMLS:C0448188 {source="ncithesaurus:Bone_of_the_Lower_Extremity"} is_a: UBERON:0002428 ! limb bone is_a: UBERON:0010742 ! bone of pelvic complex is_a: UBERON:0015022 ! hindlimb endochondral element intersection_of: UBERON:0001474 ! bone element intersection_of: BFO:0000050 UBERON:0002103 ! part of hindlimb relationship: RO:0002202 UBERON:0010885 ! develops from hindlimb cartilage element [Term] id: UBERON:0003466 name: forelimb zeugopod bone def: "A bone that is part of a lower arm [Automatically generated definition]." [OBOL:automatic] subset: pheno_slim synonym: "antebrachial region bone" EXACT [OBOL:automatic] synonym: "antebrachial region bone organ" EXACT [OBOL:automatic] synonym: "arm zeugopod bone" EXACT [OBOL:automatic] synonym: "arm zeugopod bone organ" EXACT [OBOL:automatic] synonym: "lower arm bone" EXACT [MA:0000598] synonym: "wing zeugopod bone" NARROW SENSU [NCBITaxon:8782, OBOL:automatic] synonym: "zeugopod bone, forelimb" EXACT [OBOL:automatic] synonym: "zeugopod bone, upper" EXACT [OBOL:automatic] xref: EMAPA:35347 xref: MA:0000598 is_a: UBERON:0003460 ! arm bone intersection_of: UBERON:0001474 ! bone element intersection_of: BFO:0000050 UBERON:0002386 ! part of forelimb zeugopod relationship: BFO:0000050 UBERON:0010703 ! part of forelimb zeugopod skeleton [Term] id: UBERON:0003468 name: ureteric segment of renal artery def: "The ureteral branches of renal artery are small branches which supply the ureter." [Wikipedia:Ureteral_branches_of_renal_artery] subset: human_reference_atlas synonym: "ureteric artery" BROAD [MA:0002074] xref: EMAPA:37676 {source="MA:th"} xref: FMA:70491 xref: MA:0002074 xref: SCTID:65376008 xref: Wikipedia:Ureteral_branches_of_renal_artery is_a: UBERON:0004573 ! systemic artery intersection_of: UBERON:0001637 ! artery intersection_of: RO:0020101 UBERON:0000056 ! vessel supplies blood to ureter relationship: BFO:0000050 UBERON:0001184 {source="FMA"} ! part of renal artery relationship: RO:0002252 UBERON:0001184 {source="FMA"} ! connecting branch of renal artery relationship: RO:0020101 UBERON:0000056 ! vessel supplies blood to ureter property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0003469 name: respiratory system artery def: "An artery that is part of a respiratory system [Automatically generated definition]." [OBOL:automatic] xref: EMAPA:37569 {source="MA:th"} xref: MA:0001804 is_a: UBERON:0001637 ! artery is_a: UBERON:0003643 ! respiratory system arterial blood vessel intersection_of: UBERON:0001637 ! artery intersection_of: BFO:0000050 UBERON:0001004 ! part of respiratory system property_value: skos:prefLabel "respiratory system artery" xsd:string [Term] id: UBERON:0003470 name: artery of upper lip def: "The superior labial artery (superior labial branch of facial artery) is larger and more tortuous than the inferior labial artery. It follows a similar course along the edge of the upper lip, lying between the mucous membrane and the Orbicularis oris, and anastomoses with the artery of the opposite side. It supplies the upper lip, and gives off in its course two or three vessels which ascend to the nose; a septal branch ramifies on the nasal septum as far as the point of the nose, and an alar branch supplies the ala of the nose." [Wikipedia:Superior_labial_artery] subset: human_reference_atlas synonym: "arteria labialis superior" EXACT OMO:0003011 [Wikipedia:Superior_labial_artery] synonym: "ramus labialis superior arteriae facialis" EXACT OMO:0003011 [Wikipedia:Superior_labial_artery] synonym: "superior labial artery" EXACT [FMA:49570] synonym: "superior labial branch of facial artery" EXACT [FMA:49570] xref: EMAPA:37430 {source="MA:th"} xref: FMA:49570 xref: MA:0001917 xref: SCTID:145137009 xref: Wikipedia:Superior_labial_artery is_a: UBERON:0003496 ! head blood vessel is_a: UBERON:0009657 ! artery of lip intersection_of: UBERON:0001637 ! artery intersection_of: RO:0020101 UBERON:0001834 ! vessel supplies blood to upper lip relationship: RO:0002252 UBERON:0001612 {source="FMA"} ! connecting branch of facial artery relationship: RO:0020101 UBERON:0001834 ! vessel supplies blood to upper lip property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "artery of upper lip" xsd:string [Term] id: UBERON:0003471 name: artery of lower lip def: "The inferior labial artery (inferior labial branch of facial artery) arises near the angle of the mouth; it passes upward and forward beneath the Triangularis and, penetrating the Orbicularis oris, runs in a tortuous course along the edge of the lower lip between this muscle and the mucous membrane. It supplies the labial glands, the mucous membrane, and the muscles of the lower lip; and anastomoses with the artery of the opposite side, and with the mental branch of the inferior alveolar artery." [Wikipedia:Inferior_labial_artery] subset: human_reference_atlas synonym: "arteria labialis inferior" EXACT OMO:0003011 [Wikipedia:Inferior_labial_artery] synonym: "inferior labial artery" EXACT [FMA:49567] synonym: "inferior labial branch of facial artery" EXACT [FMA:49567] synonym: "ramus labialis inferior (arteria facialis)" EXACT [FMA:TA] synonym: "ramus labialis inferior arteriae facialis" EXACT OMO:0003011 [Wikipedia:Inferior_labial_artery] xref: EMAPA:37429 {source="MA:th"} xref: FMA:49567 xref: MA:0001916 xref: SCTID:145036002 xref: Wikipedia:Inferior_labial_artery is_a: UBERON:0003496 ! head blood vessel is_a: UBERON:0009657 ! artery of lip intersection_of: UBERON:0001637 ! artery intersection_of: RO:0020101 UBERON:0001835 ! vessel supplies blood to lower lip relationship: RO:0002252 UBERON:0001612 {source="FMA"} ! connecting branch of facial artery relationship: RO:0020101 UBERON:0001835 ! vessel supplies blood to lower lip property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "artery of lower lip" xsd:string [Term] id: UBERON:0003472 name: cerebellar artery def: "An artery that supplies blood to the cerebellum." [Wikipedia:Cerebellar_artery] xref: EHDAA2:0000228 xref: EHDAA:5290 xref: EMAPA:37074 {source="MA:th"} xref: MA:0001933 xref: NCIT:C52845 xref: SCTID:278102002 xref: UMLS:C0226246 {source="ncithesaurus:Cerebellar_Artery"} xref: Wikipedia:Cerebellar_artery is_a: UBERON:0001637 ! artery is_a: UBERON:0003496 ! head blood vessel intersection_of: UBERON:0001637 ! artery intersection_of: RO:0020101 UBERON:0002037 ! vessel supplies blood to cerebellum relationship: RO:0020101 UBERON:0002037 ! vessel supplies blood to cerebellum property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/e/e1/CerebellumArteries.jpg" xsd:anyURI property_value: skos:prefLabel "cerebellar artery" xsd:string [Term] id: UBERON:0003473 name: thoracic cavity artery def: "An artery that is part of a thoracic cavity[cjm]." [https://sourceforge.net/tracker/index.php?func=detail&aid=3317815&group_id=76834&atid=1205376] synonym: "thoracic artery" RELATED [MESH:A07.231.114.891] xref: EMAPA:37241 {source="MA:th"} xref: MA:0001902 xref: MESH:D013895 is_a: UBERON:0001637 ! artery is_a: UBERON:0003519 ! thoracic cavity blood vessel intersection_of: UBERON:0001637 ! artery intersection_of: RO:0001025 UBERON:0002224 ! located in thoracic cavity property_value: skos:prefLabel "thoracic cavity artery" xsd:string [Term] id: UBERON:0003474 name: meningeal artery def: "One of the arteries supplying a meninix[Automatically generated definition]." [Wikipedia:Meningeal_arteries] xref: EMAPA:37104 {source="MA:th"} xref: GAID:499 xref: MA:0002001 xref: MESH:D008576 xref: Wikipedia:Meningeal_arteries is_a: UBERON:0001637 ! artery intersection_of: UBERON:0001637 ! artery intersection_of: RO:0020101 UBERON:0002360 ! vessel supplies blood to meninx relationship: RO:0020101 UBERON:0002360 ! vessel supplies blood to meninx property_value: skos:prefLabel "meningeal artery" xsd:string [Term] id: UBERON:0003475 name: ureteric vein def: "A vein that is part of a ureter [Automatically generated definition]." [OBOL:automatic] synonym: "ureter vein" EXACT [OBOL:automatic] synonym: "vein of ureter" EXACT [OBOL:automatic] xref: EMAPA:37679 {source="MA:th"} xref: MA:0002250 is_a: UBERON:0001638 ! vein is_a: UBERON:0003520 ! pelvis blood vessel intersection_of: UBERON:0001638 ! vein intersection_of: BFO:0000050 UBERON:0000056 ! part of ureter relationship: BFO:0000050 UBERON:0000056 ! part of ureter [Term] id: UBERON:0003476 name: respiratory system venous blood vessel def: "A vein that is part of a respiratory system [Automatically generated definition]." [OBOL:automatic] synonym: "apparatus respiratorius vein" EXACT [OBOL:automatic] synonym: "respiratory system vein" EXACT [OBOL:automatic] synonym: "vein of apparatus respiratorius" EXACT [OBOL:automatic] synonym: "vein of respiratory system" EXACT [OBOL:automatic] xref: EMAPA:37584 {source="MA:th"} xref: MA:0001809 xref: MA:0001810 is_a: UBERON:0001638 ! vein intersection_of: UBERON:0001638 ! vein intersection_of: RO:0020102 UBERON:0001004 ! vessel drains blood from respiratory system relationship: RO:0020102 UBERON:0001004 ! vessel drains blood from respiratory system property_value: skos:prefLabel "respiratory system venous blood vessel" xsd:string [Term] id: UBERON:0003477 name: vein of upper lip def: "The inferior labial vein is the vein receiving blood from the upper lip." [Wikipedia:Superior_labial_vein] subset: human_reference_atlas synonym: "superior labial vein" EXACT [FMA:52538] synonym: "upper lip vein" EXACT [OBOL:automatic] synonym: "vena labialis superior" EXACT OMO:0003011 [] xref: EMAPA:37204 {source="MA:th"} xref: FMA:52538 xref: MA:0002255 xref: SCTID:422755007 xref: Wikipedia:Superior_labial_vein is_a: UBERON:0013136 ! vein of lip intersection_of: UBERON:0001638 ! vein intersection_of: RO:0020102 UBERON:0001834 ! vessel drains blood from upper lip relationship: RO:0020102 UBERON:0001834 ! vessel drains blood from upper lip property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "vein of upper lip" xsd:string [Term] id: UBERON:0003478 name: vein of lower lip def: "The inferior labial vein is the vein receiving blood from the lower lip." [Wikipedia:Inferior_labial_vein] subset: human_reference_atlas synonym: "inferior labial vein" EXACT [FMA:52541] synonym: "lower lip vein" EXACT [OBOL:automatic] synonym: "vena labialis inferior" EXACT OMO:0003011 [] synonym: "venae labiales inferiores" RELATED OMO:0003011 [Wikipedia:Inferior_labial_vein] xref: EMAPA:37202 {source="MA:th"} xref: FMA:52541 xref: MA:0002253 xref: SCTID:422955002 xref: Wikipedia:Inferior_labial_vein is_a: UBERON:0013136 ! vein of lip intersection_of: UBERON:0001638 ! vein intersection_of: RO:0020102 UBERON:0001835 ! vessel drains blood from lower lip relationship: RO:0020102 UBERON:0001835 ! vessel drains blood from lower lip property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/8/8c/Gray557.png" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "vein of lower lip" xsd:string [Term] id: UBERON:0003479 name: thoracic cavity vein def: "A vein that is part of a thoracic cavity [Automatically generated definition]." [OBOL:automatic] synonym: "cavity of chest vein" EXACT [OBOL:automatic] synonym: "cavity of thorax vein" EXACT [OBOL:automatic] synonym: "chest cavity vein" EXACT [OBOL:automatic] synonym: "pectoral cavity vein" EXACT [OBOL:automatic] synonym: "vein of cavity of chest" EXACT [OBOL:automatic] synonym: "vein of cavity of thorax" EXACT [OBOL:automatic] synonym: "vein of chest cavity" EXACT [OBOL:automatic] synonym: "vein of pectoral cavity" EXACT [OBOL:automatic] synonym: "vein of thoracic cavity" EXACT [OBOL:automatic] xref: EMAPA:37242 {source="MA:th"} xref: MA:0001903 is_a: UBERON:0001638 ! vein is_a: UBERON:0003519 ! thoracic cavity blood vessel intersection_of: UBERON:0001638 ! vein intersection_of: RO:0001025 UBERON:0002224 ! located in thoracic cavity property_value: skos:prefLabel "thoracic cavity vein" xsd:string [Term] id: UBERON:0003480 name: vein of clitoris def: "A vein that is part of a clitoris [Automatically generated definition]." [OBOL:automatic] synonym: "clitoris vein" EXACT [OBOL:automatic] xref: EMAPA:37201 {source="MA:th"} xref: MA:0002252 xref: SCTID:360819004 is_a: UBERON:0001638 ! vein is_a: UBERON:0005156 ! reproductive structure intersection_of: UBERON:0001638 ! vein intersection_of: BFO:0000050 UBERON:0002411 ! part of clitoris relationship: BFO:0000050 UBERON:0002411 ! part of clitoris [Term] id: UBERON:0003481 name: tail vein def: "A vein that is part of a tail [Automatically generated definition]." [OBOL:automatic, Wikipedia:Tail_vein] synonym: "caudal vein" RELATED [Wikipedia:Tail_vein] synonym: "post-vent region vein" EXACT [OBOL:automatic] synonym: "vein of post-vent region" EXACT [OBOL:automatic] synonym: "vein of tail" EXACT [OBOL:automatic] xref: AAO:0011105 xref: EMAPA:37761 {source="MA:th"} xref: MA:0002233 xref: Wikipedia:Tail_vein xref: XAO:0000393 is_a: UBERON:0001638 ! vein is_a: UBERON:0003524 ! tail blood vessel intersection_of: UBERON:0001638 ! vein intersection_of: BFO:0000050 UBERON:0007812 ! part of post-anal tail property_value: IAO:0000116 "see also caudal vein" xsd:string property_value: skos:prefLabel "tail vein" xsd:string [Term] id: UBERON:0003483 name: thymus lymphoid tissue def: "A portion of lymphoid tissue that is part of a thymus [Automatically generated definition]." [OBOL:automatic] synonym: "lymphoid tissue of thymus" EXACT [OBOL:automatic] synonym: "lymphoid tissue of thymus gland" EXACT [OBOL:automatic] synonym: "thymus gland lymphoid tissue" EXACT [OBOL:automatic] xref: EMAPA:37766 {source="MA:th"} xref: MA:0002673 xref: MESH:D013950 xref: NCIT:C38515 xref: UMLS:C1515429 {source="ncithesaurus:Thymic_Lymphoid_Tissue"} is_a: UBERON:0001744 ! lymphoid tissue intersection_of: UBERON:0001744 ! lymphoid tissue intersection_of: BFO:0000050 UBERON:0002370 ! part of thymus relationship: BFO:0000050 UBERON:0002370 ! part of thymus relationship: BFO:0000051 CL:0000893 ! has part thymocyte [Term] id: UBERON:0003484 name: eye sebaceous gland def: "A sebaceous gland that is part of a camera-type eye. Example: a tarsal gland." [http://orcid.org/0000-0002-6601-2165] subset: organ_slim synonym: "camera-type eye sebaceous gland" EXACT [OBOL:automatic] synonym: "sebaceous gland of camera-type eye" EXACT [OBOL:automatic] synonym: "sebaceous gland of vertebrate eye" EXACT [OBOL:automatic] synonym: "vertebrate eye sebaceous gland" EXACT [OBOL:automatic] xref: EMAPA:37531 {source="MA:th"} xref: MA:0002452 is_a: UBERON:0003487 {source="MA"} ! skin sebaceous gland is_a: UBERON:0003605 ! eye skin gland intersection_of: UBERON:0001821 ! sebaceous gland intersection_of: BFO:0000050 UBERON:0000019 ! part of camera-type eye [Term] id: UBERON:0003485 name: vagina sebaceous gland def: "A sebaceous gland that is part of a vagina [Automatically generated definition]." [OBOL:automatic] subset: organ_slim synonym: "sebaceous gland of vagina" EXACT [OBOL:automatic] xref: EMAPA:37793 {source="MA:th"} xref: MA:0001732 is_a: UBERON:0001821 ! sebaceous gland is_a: UBERON:0005398 ! female reproductive gland intersection_of: UBERON:0001821 ! sebaceous gland intersection_of: BFO:0000050 UBERON:0000996 ! part of vagina relationship: BFO:0000050 UBERON:0000996 ! part of vagina [Term] id: UBERON:0003487 name: skin sebaceous gland def: "A holocrine gland of the dermis that secretes sebum into hair follicles." [MP:0009535] subset: pheno_slim synonym: "cutaneous sebaceous gland" EXACT [] synonym: "sebaceous gland of skin" EXACT [OBOL:automatic] xref: MA:0000149 xref: SCTID:115977007 is_a: UBERON:0001821 ! sebaceous gland [Term] id: UBERON:0003488 name: abdominal mammary gland def: "A lactiferous gland that is part of the abdominal region [Automatically generated definition]." [OBOL:automatic] synonym: "abdomen lactiferous gland" EXACT [OBOL:automatic] synonym: "abdomen lobe of breast" EXACT [OBOL:automatic] synonym: "abdomen lobe of mammary gland" EXACT [OBOL:automatic] synonym: "abdomen mammary gland" EXACT [OBOL:automatic] synonym: "lactiferous gland of abdomen" EXACT [OBOL:automatic] synonym: "lobe of breast of abdomen" EXACT [OBOL:automatic] synonym: "lobe of mammary gland of abdomen" EXACT [OBOL:automatic] synonym: "mammary gland of abdomen" EXACT [OBOL:automatic] xref: EMAPA:36507 xref: MA:0000787 xref: SCTID:113191002 xref: SCTID:68037003 is_a: UBERON:0001911 ! mammary gland is_a: UBERON:0005172 ! abdomen element intersection_of: UBERON:0001911 ! mammary gland intersection_of: BFO:0000050 UBERON:0000916 ! part of abdomen [Term] id: UBERON:0003489 name: respiratory system capillary endothelium def: "An endothelium of capillary that is part of a respiratory system [Automatically generated definition]." [OBOL:automatic] synonym: "apparatus respiratorius blood capillary endothelium" EXACT [OBOL:automatic] synonym: "apparatus respiratorius capillary endothelium" EXACT [OBOL:automatic] synonym: "apparatus respiratorius capillary vessel endothelium" EXACT [OBOL:automatic] synonym: "apparatus respiratorius endothelium of blood capillary" EXACT [OBOL:automatic] synonym: "apparatus respiratorius endothelium of capillary" EXACT [OBOL:automatic] synonym: "apparatus respiratorius endothelium of capillary vessel" EXACT [OBOL:automatic] synonym: "blood capillary endothelium of apparatus respiratorius" EXACT [OBOL:automatic] synonym: "blood capillary endothelium of respiratory system" EXACT [OBOL:automatic] synonym: "capillary endothelium of apparatus respiratorius" EXACT [OBOL:automatic] synonym: "capillary endothelium of respiratory system" EXACT [OBOL:automatic] synonym: "capillary vessel endothelium of apparatus respiratorius" EXACT [OBOL:automatic] synonym: "capillary vessel endothelium of respiratory system" EXACT [OBOL:automatic] synonym: "endothelium of blood capillary of apparatus respiratorius" EXACT [OBOL:automatic] synonym: "endothelium of blood capillary of respiratory system" EXACT [OBOL:automatic] synonym: "endothelium of capillary of apparatus respiratorius" EXACT [OBOL:automatic] synonym: "endothelium of capillary of respiratory system" EXACT [OBOL:automatic] synonym: "endothelium of capillary vessel of apparatus respiratorius" EXACT [OBOL:automatic] synonym: "endothelium of capillary vessel of respiratory system" EXACT [OBOL:automatic] synonym: "respiratory system blood capillary endothelium" EXACT [OBOL:automatic] synonym: "respiratory system capillary vessel endothelium" EXACT [OBOL:automatic] synonym: "respiratory system endothelium of blood capillary" EXACT [OBOL:automatic] synonym: "respiratory system endothelium of capillary" EXACT [OBOL:automatic] synonym: "respiratory system endothelium of capillary vessel" EXACT [OBOL:automatic] xref: EMAPA:37575 {source="MA:th"} xref: MA:0001808 is_a: UBERON:0001915 ! endothelium of capillary is_a: UBERON:0004702 ! respiratory system blood vessel endothelium intersection_of: UBERON:0001915 ! endothelium of capillary intersection_of: BFO:0000050 UBERON:0001004 ! part of respiratory system relationship: BFO:0000050 UBERON:0003526 {is_inferred="true", source="https://github.com/obophenotype/uberon/wiki/Inferring-part-of-relationships"} ! part of respiratory system capillary property_value: skos:prefLabel "respiratory system capillary endothelium" xsd:string [Term] id: UBERON:0003494 name: respiratory system venule def: "A venule that is part of a respiratory system [Automatically generated definition]." [OBOL:automatic] synonym: "apparatus respiratorius venule" EXACT [OBOL:automatic] synonym: "venule of apparatus respiratorius" EXACT [OBOL:automatic] synonym: "venule of respiratory system" EXACT [OBOL:automatic] xref: EMAPA:37587 {source="MA:th"} xref: MA:0001813 is_a: UBERON:0001979 ! venule is_a: UBERON:0003504 ! respiratory system blood vessel intersection_of: UBERON:0001979 ! venule intersection_of: BFO:0000050 UBERON:0001004 ! part of respiratory system property_value: skos:prefLabel "respiratory system venule" xsd:string [Term] id: UBERON:0003495 name: respiratory system arteriole def: "An arteriole that is part of a respiratory system [Automatically generated definition]." [OBOL:automatic] xref: EMAPA:37568 {source="MA:th"} xref: MA:0001803 is_a: UBERON:0001980 ! arteriole is_a: UBERON:0003643 ! respiratory system arterial blood vessel intersection_of: UBERON:0001980 ! arteriole intersection_of: BFO:0000050 UBERON:0001004 ! part of respiratory system relationship: BFO:0000050 UBERON:0003469 {is_inferred="true", source="https://github.com/obophenotype/uberon/wiki/Inferring-part-of-relationships"} ! part of respiratory system artery property_value: skos:prefLabel "respiratory system arteriole" xsd:string [Term] id: UBERON:0003496 name: head blood vessel def: "A blood vessel that is part of a head [Automatically generated definition]." [OBOL:automatic] synonym: "adult head blood vessel" EXACT [OBOL:automatic] synonym: "blood vessel of adult head" EXACT [OBOL:automatic] synonym: "blood vessel of head" EXACT [OBOL:automatic] xref: EMAPA:36610 xref: MA:0000575 xref: SCTID:127865000 is_a: UBERON:0001981 ! blood vessel intersection_of: UBERON:0001981 ! blood vessel intersection_of: BFO:0000050 UBERON:0000033 ! part of head relationship: BFO:0000050 UBERON:0011362 {is_inferred="true", source="https://github.com/obophenotype/uberon/wiki/Inferring-part-of-relationships"} ! part of cranial blood vasculature property_value: skos:prefLabel "head blood vessel" xsd:string [Term] id: UBERON:0003497 name: abdomen blood vessel def: "A blood vessel that is part of an abdomen [Automatically generated definition]." [OBOL:automatic] synonym: "blood vessel of abdomen" EXACT [OBOL:automatic] xref: MA:0000518 is_a: UBERON:0003835 ! abdominal segment blood vessel intersection_of: UBERON:0001981 ! blood vessel intersection_of: BFO:0000050 UBERON:0000916 ! part of abdomen relationship: BFO:0000050 UBERON:0000916 ! part of abdomen property_value: skos:prefLabel "abdomen blood vessel" xsd:string [Term] id: UBERON:0003498 name: heart blood vessel def: "A blood vessel that is part of a heart [Automatically generated definition]." [OBOL:automatic] subset: pheno_slim synonym: "blood vessel of heart" EXACT [OBOL:automatic] synonym: "cardiac blood vessel" RELATED [EMAPA:35397] xref: EMAPA:35397 xref: MA:0002483 is_a: UBERON:0003834 ! thoracic segment blood vessel is_a: UBERON:0005985 ! coronary vessel intersection_of: UBERON:0001981 ! blood vessel intersection_of: BFO:0000050 UBERON:0000948 ! part of heart relationship: BFO:0000050 UBERON:0018674 ! part of heart vasculature property_value: skos:prefLabel "heart blood vessel" xsd:string [Term] id: UBERON:0003499 name: brain blood vessel def: "A blood vessel that is part of a brain [Automatically generated definition]." [OBOL:automatic] subset: pheno_slim synonym: "blood vessel of brain" EXACT [OBOL:automatic] xref: EMAPA:35182 xref: MA:0002769 is_a: UBERON:0001981 ! blood vessel intersection_of: UBERON:0001981 ! blood vessel intersection_of: BFO:0000050 UBERON:0000955 ! part of brain relationship: BFO:0000050 UBERON:0008998 ! part of vasculature of brain property_value: skos:prefLabel "brain blood vessel" xsd:string [Term] id: UBERON:0003500 name: corneal blood vessel def: "A blood vessel that is part of a cornea [Automatically generated definition]." [https://orcid.org/0000-0002-6601-2165, https://sourceforge.net/tracker/index.php?func=detail&aid=3564332&group_id=36855&atid=440764] synonym: "blood vessel of cornea" EXACT [OBOL:automatic] synonym: "cornea blood vessel" EXACT [OBOL:automatic] xref: EMAPA:36611 xref: MA:0001241 is_a: UBERON:0003496 ! head blood vessel intersection_of: UBERON:0001981 ! blood vessel intersection_of: BFO:0000050 UBERON:0000964 ! part of cornea relationship: BFO:0000050 UBERON:0000964 ! part of cornea property_value: IAO:0000116 "follow up on tracker item" xsd:string property_value: RO:0002175 NCBITaxon:9775 {source="PMID:17051153"} property_value: skos:prefLabel "corneal blood vessel" xsd:string [Term] id: UBERON:0003501 name: retina blood vessel def: "A blood vessel that is part of a retina [Automatically generated definition]." [OBOL:automatic] subset: pheno_slim synonym: "blood vessel of inner layer of eyeball" EXACT [OBOL:automatic] synonym: "blood vessel of retina" EXACT [OBOL:automatic] synonym: "blood vessel of tunica interna of eyeball" EXACT [OBOL:automatic] synonym: "inner layer of eyeball blood vessel" EXACT [OBOL:automatic] synonym: "retinal blood vessel" EXACT [OBOL:automatic] synonym: "tunica interna of eyeball blood vessel" EXACT [OBOL:automatic] xref: EMAPA:36520 xref: GAID:509 xref: MA:0001317 xref: MESH:D012171 xref: SCTID:280692003 xref: XAO:0004153 is_a: UBERON:0003496 ! head blood vessel intersection_of: UBERON:0001981 ! blood vessel intersection_of: BFO:0000050 UBERON:0000966 ! part of retina relationship: BFO:0000050 UBERON:0004864 ! part of vasculature of retina relationship: RO:0002433 UBERON:0000966 ! contributes to morphology of retina property_value: skos:prefLabel "retina blood vessel" xsd:string [Term] id: UBERON:0003502 name: neck blood vessel def: "A blood vessel that is part of a neck [Automatically generated definition]." [OBOL:automatic] synonym: "blood vessel of neck" EXACT [OBOL:automatic] synonym: "blood vessel of neck (volume)" EXACT [OBOL:automatic] synonym: "neck (volume) blood vessel" EXACT [OBOL:automatic] xref: EMAPA:37236 {source="MA:th"} xref: MA:0000583 is_a: UBERON:0001981 ! blood vessel intersection_of: UBERON:0001981 ! blood vessel intersection_of: BFO:0000050 UBERON:0000974 ! part of neck relationship: BFO:0000050 UBERON:0000974 ! part of neck property_value: skos:prefLabel "neck blood vessel" xsd:string [Term] id: UBERON:0003503 name: leg blood vessel def: "A blood vessel that is part of a leg [Automatically generated definition]." [OBOL:automatic] synonym: "blood vessel of leg" EXACT [OBOL:automatic] xref: EMAPA:36500 xref: MA:0000669 is_a: UBERON:0003516 ! hindlimb blood vessel intersection_of: UBERON:0001981 ! blood vessel intersection_of: BFO:0000050 UBERON:0000978 ! part of leg relationship: BFO:0000050 UBERON:0000978 ! part of leg [Term] id: UBERON:0003504 name: respiratory system blood vessel def: "A blood vessel that is part of a respiratory system [Automatically generated definition]." [OBOL:automatic] synonym: "apparatus respiratorius blood vessel" EXACT [OBOL:automatic] synonym: "blood vessel of apparatus respiratorius" EXACT [OBOL:automatic] synonym: "blood vessel of respiratory system" EXACT [OBOL:automatic] xref: EMAPA:35731 xref: EMAPA:35995 xref: MA:0001799 is_a: UBERON:0001981 ! blood vessel intersection_of: UBERON:0001981 ! blood vessel intersection_of: BFO:0000050 UBERON:0001004 ! part of respiratory system relationship: BFO:0000050 UBERON:0001004 ! part of respiratory system property_value: skos:prefLabel "respiratory system blood vessel" xsd:string [Term] id: UBERON:0003505 name: trachea blood vessel def: "A blood vessel that is part of a trachea." [OBOL:automatic] synonym: "blood vessel of trachea" EXACT [OBOL:automatic] xref: EMAPA:35874 xref: MA:0001852 is_a: UBERON:0003504 ! respiratory system blood vessel intersection_of: UBERON:0001981 ! blood vessel intersection_of: BFO:0000050 UBERON:0003126 ! part of trachea relationship: BFO:0000050 UBERON:0003126 ! part of trachea property_value: skos:prefLabel "trachea blood vessel" xsd:string [Term] id: UBERON:0003506 name: chest blood vessel def: "A blood vessel that is part of a chest [Automatically generated definition]." [OBOL:automatic] synonym: "anterior thoracic region blood vessel" EXACT [OBOL:automatic] synonym: "anterolateral part of thorax blood vessel" EXACT [OBOL:automatic] synonym: "blood vessel of anterior thoracic region" EXACT [OBOL:automatic] synonym: "blood vessel of anterolateral part of thorax" EXACT [OBOL:automatic] synonym: "blood vessel of chest" EXACT [OBOL:automatic] synonym: "blood vessel of front of thorax" EXACT [OBOL:automatic] synonym: "front of thorax blood vessel" EXACT [OBOL:automatic] xref: EMAPA:37239 {source="MA:th"} xref: MA:0000549 is_a: UBERON:0003834 ! thoracic segment blood vessel intersection_of: UBERON:0001981 ! blood vessel intersection_of: BFO:0000050 UBERON:0001443 ! part of chest relationship: BFO:0000050 UBERON:0001443 ! part of chest [Term] id: UBERON:0003507 name: arm blood vessel def: "A blood vessel that is part of an arm [Automatically generated definition]." [OBOL:automatic] synonym: "blood vessel of arm" EXACT [OBOL:automatic] xref: EMAPA:37293 {source="MA:th"} xref: MA:0000591 is_a: UBERON:0003515 ! forelimb blood vessel intersection_of: UBERON:0001981 ! blood vessel intersection_of: BFO:0000050 UBERON:0001460 ! part of arm relationship: BFO:0000050 UBERON:0001460 ! part of arm [Term] id: UBERON:0003508 name: pedal digit blood vessel def: "A blood vessel that is part of a toe [Automatically generated definition]." [OBOL:automatic] synonym: "blood vessel of digit of foot" EXACT [OBOL:automatic] synonym: "blood vessel of digit of terminal segment of free lower limb" EXACT [OBOL:automatic] synonym: "blood vessel of digitus pedis" EXACT [OBOL:automatic] synonym: "blood vessel of foot digit" EXACT [OBOL:automatic] synonym: "blood vessel of terminal segment of free lower limb digit" EXACT [OBOL:automatic] synonym: "blood vessel of toe" EXACT [OBOL:automatic] synonym: "digit of foot blood vessel" EXACT [OBOL:automatic] synonym: "digit of terminal segment of free lower limb blood vessel" EXACT [OBOL:automatic] synonym: "digitus pedis blood vessel" EXACT [OBOL:automatic] synonym: "foot digit blood vessel" EXACT [MA:0000645] synonym: "foot digit blood vessel" NARROW SENSU [NCBITaxon:9606, OBOL:accepted] synonym: "hind limb digit blood vessel" EXACT [OBOL:accepted] synonym: "terminal segment of free lower limb digit blood vessel" EXACT [OBOL:automatic] synonym: "toe blood vessel" EXACT [OBOL:automatic] xref: EMAPA:37302 {source="MA:th"} xref: MA:0000645 is_a: UBERON:0003521 ! pes blood vessel intersection_of: UBERON:0001981 ! blood vessel intersection_of: BFO:0000050 UBERON:0001466 ! part of pedal digit relationship: BFO:0000050 UBERON:0001466 ! part of pedal digit [Term] id: UBERON:0003509 name: arterial blood vessel def: "A blood vessel that is part of the arterial system. Includes artery, arteriole and aorta." [https://orcid.org/0000-0002-6601-2165] comment: only in MA - supertype of artery, arteriole, aorta. subset: pheno_slim xref: EMAPA:35144 xref: MA:0000061 is_a: UBERON:0001981 ! blood vessel intersection_of: UBERON:0001981 ! blood vessel intersection_of: BFO:0000050 UBERON:0004572 ! part of arterial system relationship: BFO:0000050 UBERON:0004572 ! part of arterial system property_value: skos:prefLabel "arterial blood vessel" xsd:string [Term] id: UBERON:0003510 name: eyelid blood vessel def: "A blood vessel that is part of a eyelid [Automatically generated definition]." [OBOL:automatic] synonym: "blepharon blood vessel" EXACT [OBOL:automatic] synonym: "blood vessel of blepharon" EXACT [OBOL:automatic] synonym: "blood vessel of eyelid" EXACT [OBOL:automatic] xref: EMAPA:37388 {source="MA:th"} xref: MA:0001250 is_a: UBERON:0003496 ! head blood vessel intersection_of: UBERON:0001981 ! blood vessel intersection_of: BFO:0000050 UBERON:0001711 ! part of eyelid relationship: BFO:0000050 UBERON:0001711 ! part of eyelid [Term] id: UBERON:0003511 name: iris blood vessel def: "A blood vessel that is part of a iris [Automatically generated definition]." [OBOL:automatic] subset: vertebrate_core synonym: "blood vessel of iris" EXACT [OBOL:automatic] xref: EMAPA:37387 {source="MA:th"} xref: MA:0001290 is_a: UBERON:0003496 ! head blood vessel intersection_of: UBERON:0001981 ! blood vessel intersection_of: BFO:0000050 UBERON:0001769 ! part of iris relationship: BFO:0000050 UBERON:0004118 ! part of vasculature of iris property_value: skos:prefLabel "iris blood vessel" xsd:string [Term] id: UBERON:0003512 name: lung blood vessel def: "A blood vessel that is part of a lung [Automatically generated definition]." [OBOL:automatic] subset: pheno_slim synonym: "blood vessel of lung" EXACT [OBOL:automatic] synonym: "pulmonary vascular element" RELATED [EMAPA:32867] xref: EMAPA:32867 xref: MA:0002457 is_a: UBERON:0003504 ! respiratory system blood vessel is_a: UBERON:0003834 ! thoracic segment blood vessel intersection_of: UBERON:0001981 ! blood vessel intersection_of: BFO:0000050 UBERON:0002048 ! part of lung relationship: BFO:0000050 UBERON:0002048 ! part of lung relationship: RO:0002433 UBERON:0002048 ! contributes to morphology of lung property_value: skos:prefLabel "lung blood vessel" xsd:string [Term] id: UBERON:0003513 name: trunk blood vessel def: "A blood vessel that is part of a trunk [Automatically generated definition]." [OBOL:automatic] synonym: "blood vessel of torso" EXACT [OBOL:automatic] synonym: "blood vessel of trunk" EXACT [OBOL:automatic] synonym: "torso blood vessel" EXACT [OBOL:automatic] xref: EMAPA:37237 {source="MA:th"} xref: MA:0000511 is_a: UBERON:0001981 ! blood vessel intersection_of: UBERON:0001981 ! blood vessel intersection_of: BFO:0000050 UBERON:0002100 ! part of trunk relationship: BFO:0000050 UBERON:0002100 ! part of trunk property_value: skos:prefLabel "trunk blood vessel" xsd:string [Term] id: UBERON:0003514 name: limb blood vessel def: "A blood vessel that is part of a limb [Automatically generated definition]." [OBOL:automatic] synonym: "blood vessel of limb" EXACT [OBOL:automatic] xref: EMAPA:36598 xref: MA:0000687 is_a: UBERON:0007301 ! appendage blood vessel intersection_of: UBERON:0001981 ! blood vessel intersection_of: BFO:0000050 UBERON:0002101 ! part of limb relationship: BFO:0000050 UBERON:0002101 ! part of limb [Term] id: UBERON:0003515 name: forelimb blood vessel def: "A blood vessel that is part of a forelimb [Automatically generated definition]." [OBOL:automatic] synonym: "anteriormost limb blood vessel" EXACT [OBOL:automatic] synonym: "blood vessel of anteriormost limb" EXACT [OBOL:automatic] synonym: "blood vessel of fore limb" EXACT [OBOL:automatic] synonym: "blood vessel of forelimb" EXACT [OBOL:automatic] synonym: "blood vessel of upper extremity" EXACT [OBOL:automatic] synonym: "fore limb blood vessel" EXACT [OBOL:automatic] synonym: "wing blood vessel" NARROW SENSU [NCBITaxon:8782, OBOL:automatic] xref: EMAPA:37292 {source="MA:th"} xref: MA:0000611 is_a: UBERON:0003514 ! limb blood vessel is_a: UBERON:0007300 ! pectoral appendage blood vessel intersection_of: UBERON:0001981 ! blood vessel intersection_of: BFO:0000050 UBERON:0002102 ! part of forelimb relationship: BFO:0000050 UBERON:0002102 ! part of forelimb [Term] id: UBERON:0003516 name: hindlimb blood vessel def: "A blood vessel that is part of a hindlimb [Automatically generated definition]." [OBOL:automatic] synonym: "blood vessel of hind limb" EXACT [OBOL:automatic] synonym: "blood vessel of hindlimb" EXACT [OBOL:automatic] synonym: "blood vessel of lower extremity" EXACT [OBOL:automatic] synonym: "hind limb blood vessel" EXACT [OBOL:automatic] xref: EMAPA:37298 {source="MA:th"} xref: MA:0000659 is_a: UBERON:0003514 ! limb blood vessel intersection_of: UBERON:0001981 ! blood vessel intersection_of: BFO:0000050 UBERON:0002103 ! part of hindlimb relationship: BFO:0000050 UBERON:0002103 ! part of hindlimb [Term] id: UBERON:0003517 name: kidney blood vessel def: "A blood vessel that is part of a kidney [Automatically generated definition]." [OBOL:automatic] subset: human_reference_atlas subset: pheno_slim subset: vertebrate_core synonym: "blood vessel of kidney" EXACT [OBOL:automatic] synonym: "renal blood vessel" EXACT [OBOL:automatic] xref: MA:0001682 xref: TAO:0005306 xref: ZFA:0005306 is_a: UBERON:0003497 ! abdomen blood vessel intersection_of: UBERON:0001981 ! blood vessel intersection_of: BFO:0000050 UBERON:0002113 ! part of kidney relationship: BFO:0000050 UBERON:0006544 ! part of kidney vasculature property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0003519 name: thoracic cavity blood vessel def: "A blood vessel that is part of a thoracic cavity [Automatically generated definition]." [OBOL:automatic] synonym: "blood vessel of cavity of chest" EXACT [OBOL:automatic] synonym: "blood vessel of cavity of thorax" EXACT [OBOL:automatic] synonym: "blood vessel of chest cavity" EXACT [OBOL:automatic] synonym: "blood vessel of pectoral cavity" EXACT [OBOL:automatic] synonym: "blood vessel of thoracic cavity" EXACT [OBOL:automatic] synonym: "cavity of chest blood vessel" EXACT [OBOL:automatic] synonym: "cavity of thorax blood vessel" EXACT [OBOL:automatic] synonym: "chest cavity blood vessel" EXACT [OBOL:automatic] synonym: "pectoral cavity blood vessel" EXACT [OBOL:automatic] xref: EMAPA:37240 {source="MA:th"} xref: MA:0000554 is_a: UBERON:0001981 ! blood vessel intersection_of: UBERON:0001981 ! blood vessel intersection_of: RO:0001025 UBERON:0002224 ! located in thoracic cavity relationship: RO:0001025 UBERON:0002224 ! located in thoracic cavity property_value: skos:prefLabel "thoracic cavity blood vessel" xsd:string [Term] id: UBERON:0003520 name: pelvis blood vessel def: "A blood vessel that is part of a pelvis [Automatically generated definition]." [OBOL:automatic] synonym: "blood vessel of pelvis" EXACT [OBOL:automatic] xref: EMAPA:37244 {source="MA:th"} xref: MA:0000531 is_a: UBERON:0003835 ! abdominal segment blood vessel intersection_of: UBERON:0001981 ! blood vessel intersection_of: BFO:0000050 UBERON:0002355 ! part of pelvic region of trunk relationship: BFO:0000050 UBERON:0002355 ! part of pelvic region of trunk [Term] id: UBERON:0003521 name: pes blood vessel def: "A blood vessel that is part of a foot [Automatically generated definition]." [OBOL:automatic] synonym: "blood vessel of foot" EXACT [OBOL:automatic] synonym: "foot blood vessel" EXACT [MA:0000642] xref: EMAPA:37301 {source="MA:th"} xref: MA:0000642 is_a: UBERON:0003516 ! hindlimb blood vessel intersection_of: UBERON:0001981 ! blood vessel intersection_of: BFO:0000050 UBERON:0002387 ! part of pes relationship: BFO:0000050 UBERON:0002387 ! part of pes [Term] id: UBERON:0003522 name: manual digit blood vessel def: "A blood vessel that is part of a finger [Automatically generated definition]." [OBOL:automatic] synonym: "blood vessel of digit of terminal segment of free upper limb" EXACT [OBOL:automatic] synonym: "blood vessel of terminal segment of free upper limb digit" EXACT [OBOL:automatic] synonym: "digit of terminal segment of free upper limb blood vessel" EXACT [OBOL:automatic] synonym: "finger blood vessel" EXACT [OBOL:automatic] synonym: "hand digit blood vessel" EXACT [MA:0000621] synonym: "hand digit blood vessel" NARROW SENSU [NCBITaxon:9606, OBOL:accepted] synonym: "terminal segment of free upper limb digit blood vessel" EXACT [OBOL:automatic] xref: EMAPA:37297 {source="MA:th"} xref: MA:0000621 is_a: UBERON:0003523 ! manus blood vessel intersection_of: UBERON:0001981 ! blood vessel intersection_of: BFO:0000050 UBERON:0002389 ! part of manual digit relationship: BFO:0000050 UBERON:0002389 ! part of manual digit [Term] id: UBERON:0003523 name: manus blood vessel def: "A blood vessel that is part of a manus [Automatically generated definition]." [OBOL:automatic] synonym: "blood vessel of hand" EXACT [OBOL:automatic] synonym: "blood vessel of manus" EXACT [OBOL:automatic] synonym: "hand blood vessel" EXACT [MA:0000618] xref: EMAPA:37296 {source="MA:th"} xref: MA:0000618 is_a: UBERON:0003515 ! forelimb blood vessel intersection_of: UBERON:0001981 ! blood vessel intersection_of: BFO:0000050 UBERON:0002398 ! part of manus relationship: BFO:0000050 UBERON:0002398 ! part of manus [Term] id: UBERON:0003524 name: tail blood vessel def: "A blood vessel that is part of a tail [Automatically generated definition]." [OBOL:automatic] synonym: "blood vessel of post-vent region" EXACT [OBOL:automatic] synonym: "blood vessel of tail" EXACT [OBOL:automatic] synonym: "post-vent region blood vessel" EXACT [OBOL:automatic] xref: EMAPA:35848 xref: MA:0000695 is_a: UBERON:0001981 ! blood vessel intersection_of: UBERON:0001981 ! blood vessel intersection_of: BFO:0000050 UBERON:0007812 ! part of post-anal tail relationship: BFO:0000050 UBERON:0007812 ! part of post-anal tail property_value: skos:prefLabel "tail blood vessel" xsd:string [Term] id: UBERON:0003526 name: respiratory system capillary def: "A capillary that is part of a respiratory system [Automatically generated definition]." [OBOL:automatic] synonym: "apparatus respiratorius blood capillary" EXACT [OBOL:automatic] synonym: "apparatus respiratorius capillary" EXACT [OBOL:automatic] synonym: "apparatus respiratorius capillary vessel" EXACT [OBOL:automatic] synonym: "blood capillary of apparatus respiratorius" EXACT [OBOL:automatic] synonym: "blood capillary of respiratory system" EXACT [OBOL:automatic] synonym: "capillary of apparatus respiratorius" EXACT [OBOL:automatic] synonym: "capillary of respiratory system" EXACT [OBOL:automatic] synonym: "capillary vessel of apparatus respiratorius" EXACT [OBOL:automatic] synonym: "capillary vessel of respiratory system" EXACT [OBOL:automatic] synonym: "respiratory system blood capillary" EXACT [OBOL:automatic] synonym: "respiratory system capillary vessel" EXACT [OBOL:automatic] xref: EMAPA:37574 {source="MA:th"} xref: MA:0001807 is_a: UBERON:0001982 ! capillary is_a: UBERON:0003504 ! respiratory system blood vessel intersection_of: UBERON:0001982 ! capillary intersection_of: BFO:0000050 UBERON:0001004 ! part of respiratory system property_value: skos:prefLabel "respiratory system capillary" xsd:string [Term] id: UBERON:0003527 name: kidney capillary def: "A capillary that is part of a kidney [Automatically generated definition]." [OBOL:automatic] subset: human_reference_atlas subset: pheno_slim synonym: "blood capillary of kidney" EXACT [OBOL:automatic] synonym: "capillary of kidney" EXACT [OBOL:automatic] synonym: "capillary vessel of kidney" EXACT [OBOL:automatic] synonym: "kidney blood capillary" EXACT [OBOL:automatic] synonym: "kidney capillary vessel" EXACT [OBOL:automatic] synonym: "renal capillary" EXACT [OBOL:automatic] xref: EMAPA:31443 xref: MA:0002586 xref: SCTID:275409003 is_a: UBERON:0001982 ! capillary is_a: UBERON:0003517 ! kidney blood vessel intersection_of: UBERON:0001982 ! capillary intersection_of: BFO:0000050 UBERON:0002113 ! part of kidney property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0003528 name: brain gray matter def: "A gray matter that is part of a brain [Automatically generated definition]." [OBOL:automatic] synonym: "brain grey matter" EXACT [MA:0000810] synonym: "brain grey substance" EXACT [OBOL:automatic] synonym: "gray matter of brain" EXACT [OBOL:automatic] synonym: "grey matter of brain" EXACT [OBOL:automatic] synonym: "grey substance of brain" EXACT [OBOL:automatic] xref: EMAPA:35184 xref: MA:0000810 xref: NCIT:C49333 xref: UMLS:C1707348 {source="ncithesaurus:Cerebral_Gray_Matter"} is_a: UBERON:0002020 ! gray matter intersection_of: UBERON:0002020 ! gray matter intersection_of: BFO:0000050 UBERON:0000955 ! part of brain relationship: BFO:0000050 UBERON:0000955 ! part of brain property_value: skos:prefLabel "brain gray matter" xsd:string [Term] id: UBERON:0003529 name: respiratory system lymphatic vessel endothelium def: "An lymphatic vessel endothelium that is part of a respiratory system [Automatically generated definition]." [OBOL:automatic] subset: human_reference_atlas synonym: "apparatus respiratorius endothelium of lymph vessel" EXACT [OBOL:automatic] synonym: "apparatus respiratorius lymph vessel endothelium" EXACT [OBOL:automatic] synonym: "apparatus respiratorius lymphatic vessel endothelium" EXACT [OBOL:automatic] synonym: "endothelium of lymph vessel of apparatus respiratorius" EXACT [OBOL:automatic] synonym: "endothelium of lymph vessel of respiratory system" EXACT [OBOL:automatic] synonym: "lymph vessel endothelium of apparatus respiratorius" EXACT [OBOL:automatic] synonym: "lymph vessel endothelium of respiratory system" EXACT [OBOL:automatic] synonym: "lymphatic vessel endothelium of apparatus respiratorius" EXACT [OBOL:automatic] synonym: "lymphatic vessel endothelium of respiratory system" EXACT [OBOL:automatic] synonym: "respiratory system endothelium of lymph vessel" EXACT [OBOL:automatic] synonym: "respiratory system lymph vessel endothelium" EXACT [OBOL:automatic] synonym: "respiratory system lymphatic vessel endothelium" EXACT [OBOL:automatic] xref: EMAPA:37581 {source="MA:th"} xref: MA:0001825 is_a: UBERON:0002042 ! lymphatic vessel endothelium is_a: UBERON:0004807 ! respiratory system epithelium intersection_of: UBERON:0002042 ! lymphatic vessel endothelium intersection_of: BFO:0000050 UBERON:0001004 ! part of respiratory system relationship: BFO:0000050 UBERON:0003456 ! part of respiratory system lymphatic vessel property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0003530 name: pedal digit skin def: "A zone of skin that is part of a toe [Automatically generated definition]." [OBOL:automatic] synonym: "digit of foot skin" EXACT [OBOL:automatic] synonym: "digit of terminal segment of free lower limb skin" EXACT [OBOL:automatic] synonym: "digitus pedis skin" EXACT [OBOL:automatic] synonym: "foot digit skin" EXACT [MA:0000650] synonym: "foot digit skin" NARROW SENSU [NCBITaxon:9606, OBOL:accepted] synonym: "hind limb digit skin" EXACT [OBOL:accepted] synonym: "skin of digit of foot" EXACT [OBOL:automatic] synonym: "skin of digit of terminal segment of free lower limb" EXACT [OBOL:automatic] synonym: "skin of digitus pedis" EXACT [OBOL:automatic] synonym: "skin of foot digit" EXACT [OBOL:automatic] synonym: "skin of terminal segment of free lower limb digit" EXACT [OBOL:automatic] synonym: "skin of toe" EXACT [OBOL:automatic] synonym: "terminal segment of free lower limb digit skin" EXACT [OBOL:automatic] synonym: "toe skin" EXACT [OBOL:automatic] xref: EMAPA:32942 xref: FMA:37852 xref: MA:0000650 xref: NCIT:C52719 xref: SCTID:181530005 xref: UMLS:C1708089 {source="ncithesaurus:Foot_Digit_Skin"} is_a: UBERON:0001513 ! skin of pes is_a: UBERON:0015249 ! digit skin intersection_of: UBERON:0000014 ! zone of skin intersection_of: BFO:0000050 UBERON:0001466 ! part of pedal digit relationship: BFO:0000050 UBERON:0001466 ! part of pedal digit [Term] id: UBERON:0003531 name: forelimb skin def: "A zone of skin that is part of a forelimb [Automatically generated definition]." [OBOL:automatic] synonym: "anteriormost limb skin" EXACT [OBOL:automatic] synonym: "fore limb skin" EXACT [OBOL:automatic] synonym: "skin of fore limb" EXACT [OBOL:automatic] synonym: "skin of forelimb" EXACT [OBOL:automatic] synonym: "skin of upper limb" EXACT [FMA:23101] synonym: "upper limb skin" EXACT [FMA:23101] synonym: "wing skin" NARROW SENSU [NCBITaxon:8782, OBOL:automatic] xref: EMAPA:32612 xref: FMA:23101 xref: MA:0000617 xref: NCIT:C12296 xref: SCTID:244130001 xref: UMLS:C0222212 {source="ncithesaurus:Skin_of_the_Upper_Limb_and_Shoulder"} is_a: UBERON:0001419 ! skin of limb intersection_of: UBERON:0000014 ! zone of skin intersection_of: BFO:0000050 UBERON:0002102 ! part of forelimb relationship: BFO:0000050 UBERON:0002102 ! part of forelimb property_value: IAO:0000116 "TODO - check free limb vs pectoral complex" xsd:string [Term] id: UBERON:0003532 name: hindlimb skin def: "A zone of skin that is part of a hindlimb [Automatically generated definition]." [OBOL:automatic] synonym: "hind limb skin" EXACT [OBOL:automatic] synonym: "lower limb skin" EXACT [FMA:23102, https://orcid.org/0000-0002-0819-0473] synonym: "skin of hind limb" EXACT [OBOL:automatic] synonym: "skin of hindlimb" EXACT [OBOL:automatic] synonym: "skin of lower extremity" EXACT [OBOL:automatic] synonym: "skin of lower limb" EXACT [FMA:23102] xref: EMAPA:32620 xref: FMA:23102 xref: MA:0000665 xref: NCIT:C12297 xref: SCTID:181528008 xref: UMLS:C0222268 {source="ncithesaurus:Skin_of_the_Lower_Limb_and_Hip"} is_a: UBERON:0001419 ! skin of limb intersection_of: UBERON:0000014 ! zone of skin intersection_of: BFO:0000050 UBERON:0002103 ! part of hindlimb relationship: BFO:0000050 UBERON:0002103 ! part of hindlimb property_value: IAO:0000116 "TODO - check free limb vs pelvic complex" xsd:string [Term] id: UBERON:0003533 name: manual digit skin def: "A zone of skin that is part of a finger [Automatically generated definition]." [OBOL:automatic] synonym: "digit of hand skin" EXACT [OBOL:automatic] synonym: "digit of terminal segment of free upper limb skin" EXACT [OBOL:automatic] synonym: "digitus manus skin" EXACT [OBOL:automatic] synonym: "finger skin" EXACT [OBOL:automatic] synonym: "fore limb digit skin" EXACT [OBOL:accepted] synonym: "hand digit skin" EXACT [MA:0000626] synonym: "hand digit skin" NARROW SENSU [NCBITaxon:9606, OBOL:accepted] synonym: "skin of digit of hand" EXACT [OBOL:automatic] synonym: "skin of digit of terminal segment of free upper limb" EXACT [OBOL:automatic] synonym: "skin of digitus manus" EXACT [OBOL:automatic] synonym: "skin of finger" EXACT [OBOL:automatic] synonym: "skin of hand digit" EXACT [OBOL:automatic] synonym: "skin of terminal segment of free upper limb digit" EXACT [OBOL:automatic] synonym: "terminal segment of free upper limb digit skin" EXACT [OBOL:automatic] xref: EMAPA:32648 xref: FMA:38304 xref: MA:0000626 xref: NCIT:C52720 xref: SCTID:361711001 xref: UMLS:C1708318 {source="ncithesaurus:Hand_Digit_Skin"} is_a: UBERON:0001519 ! skin of manus is_a: UBERON:0015249 ! digit skin intersection_of: UBERON:0000014 ! zone of skin intersection_of: BFO:0000050 UBERON:0002389 ! part of manual digit relationship: BFO:0000050 UBERON:0002389 ! part of manual digit [Term] id: UBERON:0003534 name: tail skin def: "A zone of skin that is part of a tail [Automatically generated definition]." [OBOL:automatic] subset: pheno_slim synonym: "post-vent region skin" EXACT [OBOL:automatic] synonym: "skin of post-vent region" EXACT [OBOL:automatic] synonym: "skin of tail" EXACT [OBOL:automatic] xref: EMAPA:36502 xref: MA:0000700 xref: SCTID:67214004 is_a: UBERON:0000014 ! zone of skin intersection_of: UBERON:0000014 ! zone of skin intersection_of: BFO:0000050 UBERON:0007812 ! part of post-anal tail relationship: BFO:0000050 UBERON:0007812 ! part of post-anal tail property_value: skos:prefLabel "tail skin" xsd:string [Term] id: UBERON:0003535 name: vagus X nerve trunk def: "A nerve trunk that is part of a vagus nerve." [OBOL:automatic] synonym: "trunk of vagal nerve" EXACT [] synonym: "trunk of vagus nerve" EXACT [FMA:6221] synonym: "vagal nerve trunk" EXACT [EMAPA:17272] synonym: "vagal X nerve trunk" EXACT [EMAPA:17272] synonym: "vagus nerve trunk" EXACT [] synonym: "vagus neural trunk" EXACT [FMA:6221] xref: EHDAA2:0002160 xref: EHDAA:4659 xref: EMAPA:17272 xref: FMA:6221 xref: MA:0001150 xref: SCTID:280308004 xref: VHOG:0000736 is_a: UBERON:0002464 ! nerve trunk intersection_of: UBERON:0002464 ! nerve trunk intersection_of: BFO:0000050 UBERON:0001759 ! part of vagus nerve relationship: BFO:0000050 UBERON:0001759 ! part of vagus nerve [Term] id: UBERON:0003536 name: right lung alveolar duct def: "An alveolar duct that is part of a right lung [Automatically generated definition]." [OBOL:automatic] synonym: "alveolar duct of right lung" EXACT [OBOL:automatic] xref: EMAPA:35819 xref: MA:0001785 xref: NCIT:C49277 xref: UMLS:C1709958 {source="ncithesaurus:Right_Lung_Alveolar_Duct"} is_a: UBERON:0002173 ! pulmonary alveolar duct intersection_of: UBERON:0002173 ! pulmonary alveolar duct intersection_of: BFO:0000050 UBERON:0002167 ! part of right lung relationship: BFO:0000050 UBERON:0006526 ! part of right lung alveolar system [Term] id: UBERON:0003537 name: left lung alveolar duct def: "An alveolar duct that is part of a left lung [Automatically generated definition]." [OBOL:automatic] comment: Mice have 1 left lobe synonym: "alveolar duct of left lung" EXACT [OBOL:automatic] xref: EMAPA:19183 xref: MA:0001776 xref: NCIT:C49250 xref: UMLS:C1708672 {source="ncithesaurus:Left_Lung_Alveolar_Duct"} is_a: UBERON:0002173 ! pulmonary alveolar duct intersection_of: UBERON:0002173 ! pulmonary alveolar duct intersection_of: BFO:0000050 UBERON:0002168 ! part of left lung relationship: BFO:0000050 UBERON:0006525 ! part of left lung alveolar system [Term] id: UBERON:0003538 name: right lung bronchiole def: "A bronchiole that is part of a right lung [Automatically generated definition]." [OBOL:automatic] synonym: "bronchiole of right lung" EXACT [OBOL:automatic] xref: EMAPA:35425 xref: MA:0001787 xref: NCIT:C49279 xref: SCTID:200089000 xref: UMLS:C0225670 {source="ncithesaurus:Right_Lung_Bronchiole"} is_a: UBERON:0002186 ! bronchiole intersection_of: UBERON:0002186 ! bronchiole intersection_of: BFO:0000050 UBERON:0002167 ! part of right lung relationship: BFO:0000050 UBERON:0002167 ! part of right lung [Term] id: UBERON:0003539 name: left lung bronchiole def: "A bronchiole that is part of a left lung [Automatically generated definition]." [OBOL:automatic] synonym: "bronchiole of left lung" EXACT [OBOL:automatic] xref: EMAPA:19000 xref: MA:0001778 xref: NCIT:C49252 xref: SCTID:200484003 xref: UMLS:C0225674 {source="ncithesaurus:Left_Lung_Bronchiole"} is_a: UBERON:0002186 ! bronchiole intersection_of: UBERON:0002186 ! bronchiole intersection_of: BFO:0000050 UBERON:0002168 ! part of left lung relationship: BFO:0000050 UBERON:0002168 ! part of left lung [Term] id: UBERON:0003540 name: right lung terminal bronchiole def: "A terminal bronchiole that is part of a right lung [Automatically generated definition]." [OBOL:automatic] synonym: "bronchiolus terminalis of right lung" EXACT [OBOL:automatic] synonym: "right lung bronchiolus terminalis" EXACT [OBOL:automatic] synonym: "terminal bronchiole of right lung" EXACT [OBOL:automatic] xref: EMAPA:36638 xref: MA:0001789 xref: NCIT:C49294 xref: UMLS:C1709961 {source="ncithesaurus:Right_Lung_Terminal_Bronchiole"} is_a: UBERON:0002187 ! terminal bronchiole is_a: UBERON:0003538 ! right lung bronchiole intersection_of: UBERON:0002187 ! terminal bronchiole intersection_of: BFO:0000050 UBERON:0002167 ! part of right lung [Term] id: UBERON:0003541 name: left lung terminal bronchiole def: "A terminal bronchiole that is part of a left lung [Automatically generated definition]." [OBOL:automatic] synonym: "bronchiolus terminalis of left lung" EXACT [OBOL:automatic] synonym: "left lung bronchiolus terminalis" EXACT [OBOL:automatic] synonym: "terminal bronchiole of left lung" EXACT [OBOL:automatic] xref: EMAPA:36636 xref: MA:0001780 xref: NCIT:C49255 xref: UMLS:C1708675 {source="ncithesaurus:Left_Lung_Terminal_Bronchiole"} is_a: UBERON:0002187 ! terminal bronchiole is_a: UBERON:0003539 ! left lung bronchiole intersection_of: UBERON:0002187 ! terminal bronchiole intersection_of: BFO:0000050 UBERON:0002168 ! part of left lung [Term] id: UBERON:0003542 name: right lung respiratory bronchiole def: "A respiratory bronchiole that is part of a right lung [Automatically generated definition]." [OBOL:automatic] synonym: "bronchiolus respiratorius of right lung" EXACT [OBOL:automatic] synonym: "respiratory bronchiole of right lung" EXACT [OBOL:automatic] synonym: "right lung bronchiolus respiratorius" EXACT [OBOL:automatic] xref: EMAPA:36637 xref: MA:0001788 xref: NCIT:C49285 xref: UMLS:C1709960 {source="ncithesaurus:Right_Lung_Respiratory_Bronchiole"} is_a: UBERON:0002188 ! respiratory bronchiole is_a: UBERON:0003538 ! right lung bronchiole intersection_of: UBERON:0002188 ! respiratory bronchiole intersection_of: BFO:0000050 UBERON:0002167 ! part of right lung [Term] id: UBERON:0003543 name: left lung respiratory bronchiole def: "A respiratory bronchiole that is part of a left lung [Automatically generated definition]." [OBOL:automatic] synonym: "bronchiolus respiratorius of left lung" EXACT [OBOL:automatic] synonym: "left lung bronchiolus respiratorius" EXACT [OBOL:automatic] synonym: "respiratory bronchiole of left lung" EXACT [OBOL:automatic] xref: EMAPA:36635 xref: MA:0001779 xref: NCIT:C49254 xref: UMLS:C1708674 {source="ncithesaurus:Left_Lung_Respiratory_Bronchiole"} is_a: UBERON:0002188 ! respiratory bronchiole is_a: UBERON:0003539 ! left lung bronchiole intersection_of: UBERON:0002188 ! respiratory bronchiole intersection_of: BFO:0000050 UBERON:0002168 ! part of left lung [Term] id: UBERON:0003544 name: brain white matter def: "The regions of the brain that are largely or entirely composed of myelinated nerve cell axons and contain few or no neural cell bodies or dendrites." [MP:0008026] subset: pheno_slim synonym: "brain white matter of neuraxis" EXACT [OBOL:automatic] synonym: "brain white substance" EXACT [OBOL:automatic] synonym: "white matter of brain" EXACT [OBOL:automatic] synonym: "white matter of neuraxis of brain" EXACT [OBOL:automatic] synonym: "white substance of brain" EXACT [OBOL:automatic] xref: EMAPA:35187 xref: MA:0000820 xref: NCIT:C49334 xref: UMLS:C1706995 {source="ncithesaurus:Brain_White_Matter"} is_a: UBERON:0002316 ! white matter intersection_of: UBERON:0002316 ! white matter intersection_of: BFO:0000050 UBERON:0000955 ! part of brain relationship: BFO:0000050 UBERON:0000955 ! part of brain relationship: RO:0002433 UBERON:0000955 ! contributes to morphology of brain property_value: skos:prefLabel "brain white matter" xsd:string [Term] id: UBERON:0003546 name: distal convoluted tubule macula densa def: "A macula densa that is part of a distal convoluted tubule [Automatically generated definition]." [OBOL:automatic] xref: MA:0001668 is_a: UBERON:0002335 ! macula densa intersection_of: UBERON:0002335 ! macula densa intersection_of: BFO:0000050 UBERON:0001292 ! part of distal convoluted tubule relationship: BFO:0000050 UBERON:0001292 {source="MA"} ! part of distal convoluted tubule relationship: BFO:0000050 UBERON:0002335 {source="MA"} ! part of macula densa [Term] id: UBERON:0003547 name: brain meninx def: "A meninx that is part of a brain [Automatically generated definition]." [OBOL:automatic] subset: organ_slim subset: pheno_slim synonym: "brain meninges" EXACT [OBOL:automatic] synonym: "meninges of brain" EXACT [OBOL:automatic] synonym: "meninx of brain" EXACT [OBOL:automatic] xref: CALOHA:TS-2147 xref: EMAPA:32662 xref: MA:0000813 xref: SCTID:180949007 xref: VHOG:0000013 is_a: UBERON:0002360 ! meninx intersection_of: UBERON:0002360 ! meninx intersection_of: BFO:0000050 UBERON:0000955 ! part of brain relationship: BFO:0000050 UBERON:0000955 ! part of brain property_value: skos:prefLabel "brain meninx" xsd:string [Term] id: UBERON:0003548 name: forebrain meninges def: "A meninx that is part of a forebrain [Automatically generated definition]." [OBOL:automatic] synonym: "forebrain meninx" EXACT [OBOL:automatic] synonym: "meninges of forebrain" EXACT [OBOL:automatic] synonym: "meninx of forebrain" EXACT [OBOL:automatic] xref: EMAPA:37543 {source="MA:th"} xref: MA:0000883 is_a: UBERON:0003547 ! brain meninx intersection_of: UBERON:0002360 ! meninx intersection_of: BFO:0000050 UBERON:0001890 ! part of forebrain relationship: BFO:0000050 UBERON:0001890 ! part of forebrain property_value: skos:prefLabel "forebrain meninges" xsd:string [Term] id: UBERON:0003549 name: brain pia mater def: "The fibrous membrane forming the innermost of the three coverings that surrounds the brain within the cranial cavity that is firmly attached to the glial capsule." [MP:0009026] subset: pheno_slim synonym: "brain pia mater of neuraxis" EXACT [OBOL:automatic] synonym: "pia mater of brain" EXACT [OBOL:automatic] synonym: "pia mater of neuraxis of brain" EXACT [OBOL:automatic] xref: EMAPA:32667 xref: MA:0000816 xref: NCIT:C49335 xref: UMLS:C1706994 {source="ncithesaurus:Brain_Pia_Mater"} xref: VHOG:0000470 is_a: UBERON:0002361 ! pia mater is_a: UBERON:0003547 ! brain meninx intersection_of: UBERON:0002361 ! pia mater intersection_of: BFO:0000050 UBERON:0000955 ! part of brain property_value: skos:prefLabel "brain pia mater" xsd:string [Term] id: UBERON:0003550 name: forebrain pia mater def: "A pia mater that is part of a forebrain [Automatically generated definition]." [OBOL:automatic] synonym: "forebrain pia mater of neuraxis" EXACT [OBOL:automatic] synonym: "pia mater of forebrain" EXACT [OBOL:automatic] synonym: "pia mater of neuraxis of forebrain" EXACT [OBOL:automatic] xref: EMAPA:37546 {source="MA:th"} xref: MA:0000886 is_a: UBERON:0003548 ! forebrain meninges is_a: UBERON:0003549 ! brain pia mater intersection_of: UBERON:0002361 ! pia mater intersection_of: BFO:0000050 UBERON:0001890 ! part of forebrain property_value: skos:prefLabel "forebrain pia mater" xsd:string [Term] id: UBERON:0003551 name: midbrain pia mater def: "A pia mater that is part of a midbrain [Automatically generated definition]." [OBOL:automatic] synonym: "mesencephalon pia mater" RELATED [VHOG:0000467] synonym: "midbrain pia mater of neuraxis" EXACT [OBOL:automatic] synonym: "pia mater of midbrain" EXACT [OBOL:automatic] synonym: "pia mater of neuraxis of midbrain" EXACT [OBOL:automatic] xref: EHDAA2:0001175 xref: EMAPA:17794 xref: MA:0001061 xref: RETIRED_EHDAA2:0001110 xref: VHOG:0000467 is_a: UBERON:0003288 ! meninx of midbrain is_a: UBERON:0003549 ! brain pia mater intersection_of: UBERON:0002361 ! pia mater intersection_of: BFO:0000050 UBERON:0001891 ! part of midbrain property_value: skos:prefLabel "midbrain pia mater" xsd:string [Term] id: UBERON:0003552 name: telencephalon pia mater def: "A pia mater that is part of a telencephalon [Automatically generated definition]." [OBOL:automatic] synonym: "pia mater of neuraxis of telencephalon" EXACT [OBOL:automatic] synonym: "pia mater of telencephalon" EXACT [OBOL:automatic] synonym: "telencephalon pia mater of neuraxis" EXACT [OBOL:automatic] xref: EHDAA2:0001992 xref: EMAPA:17777 xref: MA:0000982 xref: VHOG:0000476 is_a: UBERON:0003289 ! meninx of telencephalon is_a: UBERON:0003550 ! forebrain pia mater intersection_of: UBERON:0002361 ! pia mater intersection_of: BFO:0000050 UBERON:0001893 ! part of telencephalon property_value: skos:prefLabel "telencephalon pia mater" xsd:string [Term] id: UBERON:0003553 name: diencephalon pia mater def: "A pia mater that is part of a diencephalon [Automatically generated definition]." [OBOL:automatic] synonym: "between brain pia mater" EXACT [OBOL:automatic] synonym: "between brain pia mater of neuraxis" EXACT [OBOL:automatic] synonym: "diencephalon pia mater of neuraxis" EXACT [OBOL:automatic] synonym: "interbrain pia mater" EXACT [OBOL:automatic] synonym: "interbrain pia mater of neuraxis" EXACT [OBOL:automatic] synonym: "mature diencephalon pia mater" EXACT [OBOL:automatic] synonym: "mature diencephalon pia mater of neuraxis" EXACT [OBOL:automatic] synonym: "pia mater of between brain" EXACT [OBOL:automatic] synonym: "pia mater of diencephalon" EXACT [OBOL:automatic] synonym: "pia mater of interbrain" EXACT [OBOL:automatic] synonym: "pia mater of mature diencephalon" EXACT [OBOL:automatic] synonym: "pia mater of neuraxis of between brain" EXACT [OBOL:automatic] synonym: "pia mater of neuraxis of diencephalon" EXACT [OBOL:automatic] synonym: "pia mater of neuraxis of interbrain" EXACT [OBOL:automatic] synonym: "pia mater of neuraxis of mature diencephalon" EXACT [OBOL:automatic] xref: EHDAA2:0000400 xref: EMAPA:17767 xref: MA:0000829 xref: VHOG:0000475 is_a: UBERON:0003290 ! meninx of diencephalon is_a: UBERON:0003550 ! forebrain pia mater intersection_of: UBERON:0002361 ! pia mater intersection_of: BFO:0000050 UBERON:0001894 ! part of diencephalon property_value: skos:prefLabel "diencephalon pia mater" xsd:string [Term] id: UBERON:0003554 name: hindbrain pia mater def: "A pia mater that is part of a hindbrain [Automatically generated definition]." [OBOL:automatic] synonym: "hindbrain pia mater of neuraxis" EXACT [OBOL:automatic] synonym: "pia mater of hindbrain" EXACT [OBOL:automatic] synonym: "pia mater of neuraxis of hindbrain" EXACT [OBOL:automatic] synonym: "rhombencephalon pia mater" RELATED [VHOG:0000466] xref: EHDAA2:0000772 xref: EMAPA:17786 xref: MA:0000990 xref: VHOG:0000466 is_a: UBERON:0003291 ! meninx of hindbrain is_a: UBERON:0003549 ! brain pia mater intersection_of: UBERON:0002361 ! pia mater intersection_of: BFO:0000050 UBERON:0002028 ! part of hindbrain property_value: skos:prefLabel "hindbrain pia mater" xsd:string [Term] id: UBERON:0003555 name: spinal cord pia mater def: "A pia mater that is part of a spinal cord [Automatically generated definition]." [OBOL:automatic] subset: organ_slim synonym: "pia mater of neuraxis of spinal cord" EXACT [OBOL:automatic] synonym: "pia mater of spinal cord" EXACT [OBOL:automatic] synonym: "spinal cord pia mater of neuraxis" EXACT [OBOL:automatic] xref: EHDAA2:0001896 xref: EMAPA:17807 xref: MA:0001133 xref: NCIT:C49800 xref: UMLS:C1710148 {source="ncithesaurus:Spinal_Cord_Pia_Mater"} xref: VHOG:0000468 is_a: UBERON:0002361 ! pia mater is_a: UBERON:0003292 ! meninx of spinal cord intersection_of: UBERON:0002361 ! pia mater intersection_of: BFO:0000050 UBERON:0002240 ! part of spinal cord property_value: skos:prefLabel "spinal cord pia mater" xsd:string [Term] id: UBERON:0003556 name: forebrain arachnoid mater def: "An arachnoid mater that is part of a forebrain [Automatically generated definition]." [OBOL:automatic] synonym: "arachnoid mater of forebrain" EXACT [OBOL:automatic] synonym: "arachnoid mater of neuraxis of forebrain" EXACT [OBOL:automatic] synonym: "arachnoid of forebrain" EXACT [OBOL:automatic] synonym: "forebrain arachnoid" EXACT [OBOL:automatic] synonym: "forebrain arachnoid mater of neuraxis" EXACT [OBOL:automatic] xref: EMAPA:37544 {source="MA:th"} xref: MA:0000884 is_a: UBERON:0002362 ! arachnoid mater is_a: UBERON:0003548 ! forebrain meninges intersection_of: UBERON:0002362 ! arachnoid mater intersection_of: BFO:0000050 UBERON:0001890 ! part of forebrain property_value: skos:prefLabel "forebrain arachnoid mater" xsd:string [Term] id: UBERON:0003557 name: midbrain arachnoid mater def: "An arachnoid mater that is part of a midbrain [Automatically generated definition]." [OBOL:automatic] synonym: "arachnoid mater of midbrain" EXACT [OBOL:automatic] synonym: "arachnoid mater of neuraxis of midbrain" EXACT [OBOL:automatic] synonym: "arachnoid of midbrain" EXACT [OBOL:automatic] synonym: "mesencephalon arachnoid mater" RELATED [VHOG:0000233] synonym: "midbrain arachnoid" EXACT [OBOL:automatic] synonym: "midbrain arachnoid mater of neuraxis" EXACT [OBOL:automatic] xref: EMAPA:17792 xref: MA:0001059 xref: VHOG:0000233 is_a: UBERON:0002362 ! arachnoid mater is_a: UBERON:0003288 ! meninx of midbrain intersection_of: UBERON:0002362 ! arachnoid mater intersection_of: BFO:0000050 UBERON:0001891 ! part of midbrain property_value: skos:prefLabel "midbrain arachnoid mater" xsd:string [Term] id: UBERON:0003558 name: diencephalon arachnoid mater def: "An arachnoid mater that is part of a diencephalon [Automatically generated definition]." [OBOL:automatic] synonym: "arachnoid mater of between brain" EXACT [OBOL:automatic] synonym: "arachnoid mater of diencephalon" EXACT [OBOL:automatic] synonym: "arachnoid mater of interbrain" EXACT [OBOL:automatic] synonym: "arachnoid mater of mature diencephalon" EXACT [OBOL:automatic] synonym: "arachnoid mater of neuraxis of between brain" EXACT [OBOL:automatic] synonym: "arachnoid mater of neuraxis of diencephalon" EXACT [OBOL:automatic] synonym: "arachnoid mater of neuraxis of interbrain" EXACT [OBOL:automatic] synonym: "arachnoid mater of neuraxis of mature diencephalon" EXACT [OBOL:automatic] synonym: "arachnoid of between brain" EXACT [OBOL:automatic] synonym: "arachnoid of diencephalon" EXACT [OBOL:automatic] synonym: "arachnoid of interbrain" EXACT [OBOL:automatic] synonym: "arachnoid of mature diencephalon" EXACT [OBOL:automatic] synonym: "between brain arachnoid" EXACT [OBOL:automatic] synonym: "between brain arachnoid mater" EXACT [OBOL:automatic] synonym: "between brain arachnoid mater of neuraxis" EXACT [OBOL:automatic] synonym: "diencephalon arachnoid" EXACT [OBOL:automatic] synonym: "diencephalon arachnoid mater of neuraxis" EXACT [OBOL:automatic] synonym: "interbrain arachnoid" EXACT [OBOL:automatic] synonym: "interbrain arachnoid mater" EXACT [OBOL:automatic] synonym: "interbrain arachnoid mater of neuraxis" EXACT [OBOL:automatic] synonym: "mature diencephalon arachnoid" EXACT [OBOL:automatic] synonym: "mature diencephalon arachnoid mater" EXACT [OBOL:automatic] synonym: "mature diencephalon arachnoid mater of neuraxis" EXACT [OBOL:automatic] xref: EMAPA:17765 xref: MA:0000827 xref: VHOG:0000231 is_a: UBERON:0003290 ! meninx of diencephalon is_a: UBERON:0003556 ! forebrain arachnoid mater intersection_of: UBERON:0002362 ! arachnoid mater intersection_of: BFO:0000050 UBERON:0001894 ! part of diencephalon property_value: skos:prefLabel "diencephalon arachnoid mater" xsd:string [Term] id: UBERON:0003559 name: hindbrain arachnoid mater def: "An arachnoid mater that is part of a hindbrain [Automatically generated definition]." [OBOL:automatic] synonym: "arachnoid mater of hindbrain" EXACT [OBOL:automatic] synonym: "arachnoid mater of neuraxis of hindbrain" EXACT [OBOL:automatic] synonym: "arachnoid of hindbrain" EXACT [OBOL:automatic] synonym: "hindbrain arachnoid" EXACT [OBOL:automatic] synonym: "hindbrain arachnoid mater of neuraxis" EXACT [OBOL:automatic] synonym: "rhombencephalon arachnoid mater" RELATED [VHOG:0000236] xref: EMAPA:17784 xref: MA:0000988 xref: VHOG:0000236 is_a: UBERON:0002362 ! arachnoid mater is_a: UBERON:0003291 ! meninx of hindbrain intersection_of: UBERON:0002362 ! arachnoid mater intersection_of: BFO:0000050 UBERON:0002028 ! part of hindbrain property_value: skos:prefLabel "hindbrain arachnoid mater" xsd:string [Term] id: UBERON:0003560 name: spinal cord arachnoid mater def: "An arachnoid mater that is part of a spinal cord [Automatically generated definition]." [OBOL:automatic] subset: organ_slim synonym: "arachnoid mater of neuraxis of spinal cord" EXACT [OBOL:automatic] synonym: "arachnoid mater of spinal cord" EXACT [OBOL:automatic] synonym: "arachnoid of spinal cord" EXACT [OBOL:automatic] synonym: "spinal cord arachnoid" EXACT [OBOL:automatic] synonym: "spinal cord arachnoid mater of neuraxis" EXACT [OBOL:automatic] xref: EMAPA:17805 xref: MA:0001131 xref: VHOG:0000234 is_a: UBERON:0002362 ! arachnoid mater is_a: UBERON:0003292 ! meninx of spinal cord intersection_of: UBERON:0002362 ! arachnoid mater intersection_of: BFO:0000050 UBERON:0002240 ! part of spinal cord property_value: skos:prefLabel "spinal cord arachnoid mater" xsd:string [Term] id: UBERON:0003561 name: forebrain dura mater def: "A dura mater that is part of a forebrain." [OBOL:automatic] synonym: "dura mater of forebrain" EXACT [OBOL:automatic] synonym: "dura mater of neuraxis of forebrain" EXACT [OBOL:automatic] synonym: "forebrain dura mater of neuraxis" EXACT [OBOL:automatic] xref: EMAPA:37545 {source="MA:th"} xref: MA:0000885 is_a: UBERON:0002092 ! brain dura mater is_a: UBERON:0003548 ! forebrain meninges intersection_of: UBERON:0002363 ! dura mater intersection_of: BFO:0000050 UBERON:0001890 ! part of forebrain property_value: skos:prefLabel "forebrain dura mater" xsd:string [Term] id: UBERON:0003562 name: midbrain dura mater def: "A dura mater that is part of a midbrain [Automatically generated definition]." [OBOL:automatic] synonym: "dura mater of midbrain" EXACT [OBOL:automatic] synonym: "dura mater of neuraxis of midbrain" EXACT [OBOL:automatic] synonym: "mesencephalon dura mater" RELATED [VHOG:0000410] synonym: "midbrain dura mater of neuraxis" EXACT [OBOL:automatic] xref: EMAPA:17793 xref: MA:0001060 xref: VHOG:0000410 is_a: UBERON:0002092 ! brain dura mater is_a: UBERON:0003288 ! meninx of midbrain intersection_of: UBERON:0002363 ! dura mater intersection_of: BFO:0000050 UBERON:0001891 ! part of midbrain property_value: skos:prefLabel "midbrain dura mater" xsd:string [Term] id: UBERON:0003563 name: telencephalon dura mater def: "A dura mater that is part of a telencephalon [Automatically generated definition]." [OBOL:automatic] synonym: "dura mater of neuraxis of telencephalon" EXACT [OBOL:automatic] synonym: "dura mater of telencephalon" EXACT [OBOL:automatic] synonym: "telencephalon dura mater of neuraxis" EXACT [OBOL:automatic] xref: EMAPA:17776 xref: MA:0000981 is_a: UBERON:0003289 ! meninx of telencephalon is_a: UBERON:0003561 ! forebrain dura mater intersection_of: UBERON:0002363 ! dura mater intersection_of: BFO:0000050 UBERON:0001893 ! part of telencephalon property_value: skos:prefLabel "telencephalon dura mater" xsd:string [Term] id: UBERON:0003564 name: diencephalon dura mater def: "A dura mater that is part of a diencephalon [Automatically generated definition]." [OBOL:automatic] synonym: "between brain dura mater" EXACT [OBOL:automatic] synonym: "between brain dura mater of neuraxis" EXACT [OBOL:automatic] synonym: "diencephalon dura mater of neuraxis" EXACT [OBOL:automatic] synonym: "dura mater of between brain" EXACT [OBOL:automatic] synonym: "dura mater of diencephalon" EXACT [OBOL:automatic] synonym: "dura mater of interbrain" EXACT [OBOL:automatic] synonym: "dura mater of mature diencephalon" EXACT [OBOL:automatic] synonym: "dura mater of neuraxis of between brain" EXACT [OBOL:automatic] synonym: "dura mater of neuraxis of diencephalon" EXACT [OBOL:automatic] synonym: "dura mater of neuraxis of interbrain" EXACT [OBOL:automatic] synonym: "dura mater of neuraxis of mature diencephalon" EXACT [OBOL:automatic] synonym: "interbrain dura mater" EXACT [OBOL:automatic] synonym: "interbrain dura mater of neuraxis" EXACT [OBOL:automatic] synonym: "mature diencephalon dura mater" EXACT [OBOL:automatic] synonym: "mature diencephalon dura mater of neuraxis" EXACT [OBOL:automatic] xref: EMAPA:17766 xref: MA:0000828 xref: VHOG:0000258 is_a: UBERON:0003290 ! meninx of diencephalon is_a: UBERON:0003561 ! forebrain dura mater intersection_of: UBERON:0002363 ! dura mater intersection_of: BFO:0000050 UBERON:0001894 ! part of diencephalon property_value: skos:prefLabel "diencephalon dura mater" xsd:string [Term] id: UBERON:0003565 name: hindbrain dura mater def: "A dura mater that is part of a hindbrain [Automatically generated definition]." [OBOL:automatic] synonym: "dura mater of hindbrain" EXACT [OBOL:automatic] synonym: "dura mater of neuraxis of hindbrain" EXACT [OBOL:automatic] synonym: "hindbrain dura mater of neuraxis" EXACT [OBOL:automatic] synonym: "rhombencephalon dura mater" RELATED [VHOG:0000409] xref: EMAPA:17785 xref: MA:0000989 xref: VHOG:0000409 is_a: UBERON:0002092 ! brain dura mater is_a: UBERON:0003291 ! meninx of hindbrain intersection_of: UBERON:0002363 ! dura mater intersection_of: BFO:0000050 UBERON:0002028 ! part of hindbrain property_value: skos:prefLabel "hindbrain dura mater" xsd:string [Term] id: UBERON:0003566 name: head connective tissue def: "A portion of connective tissue that is part of a head [Automatically generated definition]." [OBOL:automatic] synonym: "adult head connective tissue" EXACT [OBOL:automatic] synonym: "adult head portion of connective tissue" EXACT [OBOL:automatic] synonym: "adult head textus connectivus" EXACT [OBOL:automatic] synonym: "connective tissue of adult head" EXACT [OBOL:automatic] synonym: "connective tissue of head" EXACT [OBOL:automatic] synonym: "head portion of connective tissue" EXACT [OBOL:automatic] synonym: "head textus connectivus" EXACT [OBOL:automatic] synonym: "portion of connective tissue of adult head" EXACT [OBOL:automatic] synonym: "portion of connective tissue of head" EXACT [OBOL:automatic] synonym: "textus connectivus of adult head" EXACT [OBOL:automatic] synonym: "textus connectivus of head" EXACT [OBOL:automatic] xref: MA:0000577 is_a: BFO:0000002 is_a: UBERON:0002384 ! connective tissue intersection_of: UBERON:0002384 ! connective tissue intersection_of: BFO:0000050 UBERON:0000033 ! part of head relationship: BFO:0000050 UBERON:0000033 ! part of head relationship: RO:0002494 UBERON:0005253 ! transformation of head mesenchyme property_value: skos:prefLabel "head connective tissue" xsd:string [Term] id: UBERON:0003567 name: abdomen connective tissue def: "A portion of connective tissue that is part of an abdomen [Automatically generated definition]." [OBOL:automatic] synonym: "abdomen portion of connective tissue" EXACT [OBOL:automatic] synonym: "abdomen textus connectivus" EXACT [OBOL:automatic] synonym: "connective tissue of abdomen" EXACT [OBOL:automatic] synonym: "portion of connective tissue of abdomen" EXACT [OBOL:automatic] synonym: "textus connectivus of abdomen" EXACT [OBOL:automatic] xref: MA:0000519 is_a: UBERON:0003838 ! abdominal segment connective tissue intersection_of: UBERON:0002384 ! connective tissue intersection_of: BFO:0000050 UBERON:0000916 ! part of abdomen relationship: BFO:0000050 UBERON:0000916 ! part of abdomen property_value: skos:prefLabel "abdomen connective tissue" xsd:string [Term] id: UBERON:0003568 name: neck connective tissue def: "A portion of connective tissue that is part of a neck [Automatically generated definition]." [OBOL:automatic] synonym: "connective tissue of neck" EXACT [OBOL:automatic] synonym: "connective tissue of neck (volume)" EXACT [OBOL:automatic] synonym: "neck (volume) connective tissue" EXACT [OBOL:automatic] synonym: "neck (volume) portion of connective tissue" EXACT [OBOL:automatic] synonym: "neck (volume) textus connectivus" EXACT [OBOL:automatic] synonym: "neck portion of connective tissue" EXACT [OBOL:automatic] synonym: "neck textus connectivus" EXACT [OBOL:automatic] synonym: "portion of connective tissue of neck" EXACT [OBOL:automatic] synonym: "portion of connective tissue of neck (volume)" EXACT [OBOL:automatic] synonym: "textus connectivus of neck" EXACT [OBOL:automatic] synonym: "textus connectivus of neck (volume)" EXACT [OBOL:automatic] xref: EMAPA:37250 {source="MA:th"} xref: MA:0000585 is_a: UBERON:0002384 ! connective tissue intersection_of: UBERON:0002384 ! connective tissue intersection_of: BFO:0000050 UBERON:0000974 ! part of neck relationship: BFO:0000050 UBERON:0000974 ! part of neck property_value: skos:prefLabel "neck connective tissue" xsd:string [Term] id: UBERON:0003569 name: leg connective tissue def: "A portion of connective tissue that is part of a leg [Automatically generated definition]." [OBOL:automatic] synonym: "connective tissue of leg" EXACT [OBOL:automatic] synonym: "leg portion of connective tissue" EXACT [OBOL:automatic] synonym: "leg textus connectivus" EXACT [OBOL:automatic] synonym: "portion of connective tissue of leg" EXACT [OBOL:automatic] synonym: "textus connectivus of leg" EXACT [OBOL:automatic] xref: EMAPA:37324 {source="MA:th"} xref: MA:0000671 is_a: UBERON:0003589 ! hindlimb connective tissue intersection_of: UBERON:0002384 ! connective tissue intersection_of: BFO:0000050 UBERON:0000978 ! part of leg relationship: BFO:0000050 UBERON:0000978 ! part of leg [Term] id: UBERON:0003570 name: respiratory system connective tissue def: "A portion of connective tissue that is part of a respiratory system [Automatically generated definition]." [OBOL:automatic] synonym: "apparatus respiratorius connective tissue" EXACT [OBOL:automatic] synonym: "apparatus respiratorius portion of connective tissue" EXACT [OBOL:automatic] synonym: "apparatus respiratorius textus connectivus" EXACT [OBOL:automatic] synonym: "connective tissue of apparatus respiratorius" EXACT [OBOL:automatic] synonym: "connective tissue of respiratory system" EXACT [OBOL:automatic] synonym: "portion of connective tissue of apparatus respiratorius" EXACT [OBOL:automatic] synonym: "portion of connective tissue of respiratory system" EXACT [OBOL:automatic] synonym: "respiratory system portion of connective tissue" EXACT [OBOL:automatic] synonym: "respiratory system textus connectivus" EXACT [OBOL:automatic] synonym: "textus connectivus of apparatus respiratorius" EXACT [OBOL:automatic] synonym: "textus connectivus of respiratory system" EXACT [OBOL:automatic] xref: EMAPA:35968 xref: EMAPA:35977 xref: MA:0001814 is_a: UBERON:0002384 ! connective tissue intersection_of: UBERON:0002384 ! connective tissue intersection_of: BFO:0000050 UBERON:0001004 ! part of respiratory system relationship: BFO:0000050 UBERON:0001004 ! part of respiratory system property_value: skos:prefLabel "respiratory system connective tissue" xsd:string [Term] id: UBERON:0003571 name: trachea connective tissue def: "A portion of connective tissue that is part of a trachea." [OBOL:automatic] subset: human_reference_atlas synonym: "connective tissue of trachea" EXACT [OBOL:automatic] synonym: "connective tissue of windpipe" EXACT [OBOL:automatic] xref: EMAPA:35876 xref: MA:0001853 is_a: BFO:0000002 is_a: UBERON:0003580 ! lower respiratory tract connective tissue intersection_of: UBERON:0002384 ! connective tissue intersection_of: BFO:0000050 UBERON:0003126 ! part of trachea relationship: BFO:0000050 UBERON:0003126 ! part of trachea relationship: RO:0002494 UBERON:0009505 ! transformation of mesenchyme of trachea property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "trachea connective tissue" xsd:string [Term] id: UBERON:0003572 name: chest connective tissue def: "A portion of connective tissue that is part of a chest [Automatically generated definition]." [OBOL:automatic] synonym: "anterior thoracic region connective tissue" EXACT [OBOL:automatic] synonym: "anterior thoracic region portion of connective tissue" EXACT [OBOL:automatic] synonym: "anterior thoracic region textus connectivus" EXACT [OBOL:automatic] synonym: "anterolateral part of thorax connective tissue" EXACT [OBOL:automatic] synonym: "anterolateral part of thorax portion of connective tissue" EXACT [OBOL:automatic] synonym: "anterolateral part of thorax textus connectivus" EXACT [OBOL:automatic] synonym: "chest portion of connective tissue" EXACT [OBOL:automatic] synonym: "chest textus connectivus" EXACT [OBOL:automatic] synonym: "connective tissue of anterior thoracic region" EXACT [OBOL:automatic] synonym: "connective tissue of anterolateral part of thorax" EXACT [OBOL:automatic] synonym: "connective tissue of chest" EXACT [OBOL:automatic] synonym: "connective tissue of front of thorax" EXACT [OBOL:automatic] synonym: "front of thorax connective tissue" EXACT [OBOL:automatic] synonym: "front of thorax portion of connective tissue" EXACT [OBOL:automatic] synonym: "front of thorax textus connectivus" EXACT [OBOL:automatic] synonym: "portion of connective tissue of anterior thoracic region" EXACT [OBOL:automatic] synonym: "portion of connective tissue of anterolateral part of thorax" EXACT [OBOL:automatic] synonym: "portion of connective tissue of chest" EXACT [OBOL:automatic] synonym: "portion of connective tissue of front of thorax" EXACT [OBOL:automatic] synonym: "textus connectivus of anterior thoracic region" EXACT [OBOL:automatic] synonym: "textus connectivus of anterolateral part of thorax" EXACT [OBOL:automatic] synonym: "textus connectivus of chest" EXACT [OBOL:automatic] synonym: "textus connectivus of front of thorax" EXACT [OBOL:automatic] xref: EMAPA:37254 {source="MA:th"} xref: MA:0000550 is_a: UBERON:0003837 ! thoracic segment connective tissue intersection_of: UBERON:0002384 ! connective tissue intersection_of: BFO:0000050 UBERON:0001443 ! part of chest relationship: BFO:0000050 UBERON:0001443 ! part of chest [Term] id: UBERON:0003573 name: arm connective tissue def: "A portion of connective tissue that is part of an arm [Automatically generated definition]." [OBOL:automatic] xref: EMAPA:37316 {source="MA:th"} xref: MA:0000593 is_a: UBERON:0003588 ! forelimb connective tissue intersection_of: UBERON:0002384 ! connective tissue intersection_of: BFO:0000050 UBERON:0001460 ! part of arm relationship: BFO:0000050 UBERON:0001460 ! part of arm [Term] id: UBERON:0003574 name: elbow connective tissue def: "A portion of connective tissue that is part of a elbow [Automatically generated definition]." [OBOL:automatic] synonym: "connective tissue of cubital region" EXACT [OBOL:automatic] synonym: "connective tissue of elbow" EXACT [OBOL:automatic] synonym: "textus connectivus of cubital region" EXACT [OBOL:automatic] xref: EMAPA:37318 {source="MA:th"} xref: MA:0000609 is_a: UBERON:0003573 ! arm connective tissue intersection_of: UBERON:0002384 ! connective tissue intersection_of: BFO:0000050 UBERON:0001461 ! part of elbow relationship: BFO:0000050 UBERON:0001461 ! part of elbow relationship: RO:0002494 UBERON:0003318 ! transformation of mesenchyme of elbow [Term] id: UBERON:0003575 name: wrist connective tissue def: "A portion of connective tissue that is part of a wrist [Automatically generated definition]." [OBOL:automatic] synonym: "carpal region connective tissue" EXACT [OBOL:automatic] synonym: "connective tissue of carpal region" EXACT [OBOL:automatic] synonym: "connective tissue of wrist" EXACT [OBOL:automatic] xref: EMAPA:37320 {source="MA:th"} xref: MA:0000636 is_a: UBERON:0003598 ! manus connective tissue intersection_of: UBERON:0002384 ! connective tissue intersection_of: BFO:0000050 UBERON:0004452 ! part of carpal region relationship: BFO:0000050 UBERON:0004452 ! part of carpal region relationship: RO:0002494 UBERON:0003319 ! transformation of mesenchyme of carpal region [Term] id: UBERON:0003576 name: hip connective tissue def: "A portion of connective tissue that is part of a hip [Automatically generated definition]." [OBOL:automatic] synonym: "connective tissue of hip" EXACT [OBOL:automatic] synonym: "connective tissue of hip region" EXACT [OBOL:automatic] synonym: "connective tissue of regio coxae" EXACT [OBOL:automatic] xref: EMAPA:37323 {source="MA:th"} xref: MA:0000656 is_a: BFO:0000002 is_a: UBERON:0002384 ! connective tissue intersection_of: UBERON:0002384 ! connective tissue intersection_of: BFO:0000050 UBERON:0001464 ! part of hip relationship: BFO:0000050 UBERON:0001464 ! part of hip relationship: RO:0002494 UBERON:0003320 ! transformation of mesenchyme of hip [Term] id: UBERON:0003577 name: knee connective tissue def: "A portion of connective tissue that is part of a knee [Automatically generated definition]." [OBOL:automatic] synonym: "connective tissue of knee" EXACT [OBOL:automatic] synonym: "knee portion of connective tissue" EXACT [OBOL:automatic] xref: EMAPA:37326 {source="MA:th"} xref: MA:0000667 is_a: UBERON:0003569 ! leg connective tissue intersection_of: UBERON:0002384 ! connective tissue intersection_of: BFO:0000050 UBERON:0001465 ! part of knee relationship: BFO:0000050 UBERON:0001465 ! part of knee relationship: RO:0002494 UBERON:0003321 ! transformation of mesenchyme of knee [Term] id: UBERON:0003578 name: pedal digit connective tissue def: "A portion of connective tissue that is part of a toe [Automatically generated definition]." [OBOL:automatic] synonym: "connective tissue of digit of foot" EXACT [OBOL:automatic] synonym: "connective tissue of digitus pedis" EXACT [OBOL:automatic] synonym: "connective tissue of foot digit" EXACT [OBOL:automatic] synonym: "connective tissue of toe" EXACT [OBOL:automatic] synonym: "digitus pedis textus connectivus" EXACT [OBOL:automatic] synonym: "foot digit connective tissue" EXACT [MA:0000647] synonym: "foot digit connective tissue" NARROW SENSU [NCBITaxon:9606, OBOL:accepted] synonym: "hind limb digit connective tissue" EXACT [OBOL:accepted] xref: EMAPA:37330 {source="MA:th"} xref: MA:0000647 is_a: UBERON:0003595 ! pes connective tissue is_a: UBERON:0015791 ! digit connective tissue intersection_of: UBERON:0002384 ! connective tissue intersection_of: BFO:0000050 UBERON:0001466 ! part of pedal digit relationship: BFO:0000050 UBERON:0001466 ! part of pedal digit relationship: RO:0002494 UBERON:0005255 ! transformation of pedal digit mesenchyme [Term] id: UBERON:0003579 name: shoulder connective tissue def: "A portion of connective tissue that is part of a shoulder [Automatically generated definition]." [OBOL:automatic] synonym: "connective tissue of shoulder" EXACT [OBOL:automatic] synonym: "portion of connective tissue of shoulder" EXACT [OBOL:automatic] synonym: "shoulder portion of connective tissue" EXACT [OBOL:automatic] synonym: "shoulder textus connectivus" EXACT [OBOL:automatic] synonym: "textus connectivus of shoulder" EXACT [OBOL:automatic] xref: EMAPA:37315 {source="MA:th"} xref: MA:0000632 is_a: BFO:0000002 is_a: UBERON:0002384 ! connective tissue intersection_of: UBERON:0002384 ! connective tissue intersection_of: BFO:0000050 UBERON:0001467 ! part of shoulder relationship: BFO:0000050 UBERON:0001467 ! part of shoulder relationship: RO:0002494 UBERON:0003322 ! transformation of mesenchyme of shoulder [Term] id: UBERON:0003580 name: lower respiratory tract connective tissue def: "A portion of connective tissue that is part of a lower respiratory tract [Automatically generated definition]." [OBOL:automatic] synonym: "connective tissue of lower respiratory tract" EXACT [OBOL:automatic] synonym: "lower respiratory tract portion of connective tissue" EXACT [OBOL:automatic] synonym: "lower respiratory tract textus connectivus" EXACT [OBOL:automatic] synonym: "portion of connective tissue of lower respiratory tract" EXACT [OBOL:automatic] synonym: "textus connectivus of lower respiratory tract" EXACT [OBOL:automatic] xref: EMAPA:37548 {source="MA:th"} xref: MA:0002409 is_a: UBERON:0003570 ! respiratory system connective tissue intersection_of: UBERON:0002384 ! connective tissue intersection_of: BFO:0000050 UBERON:0001558 ! part of lower respiratory tract relationship: BFO:0000050 UBERON:0001558 ! part of lower respiratory tract property_value: skos:prefLabel "lower respiratory tract connective tissue" xsd:string [Term] id: UBERON:0003581 name: eyelid connective tissue def: "A portion of connective tissue that is part of a eyelid [Automatically generated definition]." [OBOL:automatic] synonym: "blepharon connective tissue" EXACT [OBOL:automatic] synonym: "connective tissue of blepharon" EXACT [OBOL:automatic] synonym: "connective tissue of eyelid" EXACT [OBOL:automatic] xref: EMAPA:37532 {source="MA:th"} xref: MA:0001251 xref: NCIT:C49482 xref: UMLS:C1707989 {source="ncithesaurus:Eyelid_Connective_Tissue"} is_a: UBERON:0003566 ! head connective tissue intersection_of: UBERON:0002384 ! connective tissue intersection_of: BFO:0000050 UBERON:0001711 ! part of eyelid relationship: BFO:0000050 UBERON:0001711 ! part of eyelid relationship: RO:0002494 UBERON:0010330 ! transformation of eyelid mesenchyme [Term] id: UBERON:0003582 name: nasopharynx connective tissue def: "A portion of connective tissue that is part of a nasopharynx [Automatically generated definition]." [OBOL:automatic] synonym: "connective tissue of nasal part of pharynx" EXACT [OBOL:automatic] synonym: "connective tissue of nasopharynx" EXACT [OBOL:automatic] synonym: "connective tissue of rhinopharynx" EXACT [OBOL:automatic] synonym: "nasal part of pharynx connective tissue" EXACT [OBOL:automatic] synonym: "nasal part of pharynx portion of connective tissue" EXACT [OBOL:automatic] synonym: "nasal part of pharynx textus connectivus" EXACT [OBOL:automatic] synonym: "nasopharynx portion of connective tissue" EXACT [OBOL:automatic] synonym: "nasopharynx textus connectivus" EXACT [OBOL:automatic] synonym: "portion of connective tissue of nasal part of pharynx" EXACT [OBOL:automatic] synonym: "portion of connective tissue of nasopharynx" EXACT [OBOL:automatic] synonym: "portion of connective tissue of rhinopharynx" EXACT [OBOL:automatic] synonym: "rhinopharynx connective tissue" EXACT [OBOL:automatic] synonym: "rhinopharynx portion of connective tissue" EXACT [OBOL:automatic] synonym: "rhinopharynx textus connectivus" EXACT [OBOL:automatic] synonym: "textus connectivus of nasal part of pharynx" EXACT [OBOL:automatic] synonym: "textus connectivus of nasopharynx" EXACT [OBOL:automatic] synonym: "textus connectivus of rhinopharynx" EXACT [OBOL:automatic] xref: EMAPA:37682 {source="MA:th"} xref: MA:0001864 is_a: UBERON:0003570 ! respiratory system connective tissue intersection_of: UBERON:0002384 ! connective tissue intersection_of: BFO:0000050 UBERON:0001728 ! part of nasopharynx relationship: BFO:0000050 UBERON:0001728 ! part of nasopharynx [Term] id: UBERON:0003583 name: larynx connective tissue def: "A portion of connective tissue that is part of a larynx [Automatically generated definition]." [OBOL:automatic] synonym: "connective tissue of larynx" EXACT [OBOL:automatic] synonym: "laryngeal connective tissue" RELATED [EMAPA:35471] synonym: "larynx portion of connective tissue" EXACT [OBOL:automatic] synonym: "larynx textus connectivus" EXACT [OBOL:automatic] synonym: "portion of connective tissue of larynx" EXACT [OBOL:automatic] synonym: "textus connectivus of larynx" EXACT [OBOL:automatic] xref: EMAPA:35471 xref: MA:0001754 xref: NCIT:C49245 xref: UMLS:C1708651 {source="ncithesaurus:Laryngeal_Connective_Tissue"} is_a: UBERON:0003570 ! respiratory system connective tissue intersection_of: UBERON:0002384 ! connective tissue intersection_of: BFO:0000050 UBERON:0001737 ! part of larynx relationship: BFO:0000050 UBERON:0001737 ! part of larynx property_value: skos:prefLabel "larynx connective tissue" xsd:string [Term] id: UBERON:0003584 name: mammary gland connective tissue def: "The fibrous supportive tissue of the mammary gland." [https://github.com/obophenotype/uberon/issues/1151, MP:0009507] subset: pheno_slim synonym: "connective tissue of lactiferous gland" EXACT [OBOL:automatic] synonym: "connective tissue of lobe of breast" EXACT [OBOL:automatic] synonym: "connective tissue of lobe of mammary gland" EXACT [OBOL:automatic] synonym: "connective tissue of mammary gland" EXACT [OBOL:automatic] synonym: "lactiferous gland connective tissue" EXACT [OBOL:automatic] synonym: "lactiferous gland portion of connective tissue" EXACT [OBOL:automatic] synonym: "lactiferous gland stroma" EXACT [https://github.com/obophenotype/uberon/issues/1151] synonym: "mammary gland stroma" EXACT [https://github.com/obophenotype/uberon/issues/1151] synonym: "mammary stroma" EXACT [https://github.com/obophenotype/uberon/issues/1151] synonym: "stroma of lactiferous gland" EXACT [FMA:74483] xref: EMAPA:35537 xref: FMA:74479 xref: FMA:74483 xref: MA:0002897 is_a: BFO:0000002 is_a: UBERON:0002384 ! connective tissue intersection_of: UBERON:0002384 ! connective tissue intersection_of: BFO:0000050 UBERON:0001911 ! part of mammary gland relationship: BFO:0000050 UBERON:0001911 ! part of mammary gland relationship: RO:0002433 UBERON:0001911 ! contributes to morphology of mammary gland relationship: RO:0002494 UBERON:0003326 ! transformation of mesenchyme of mammary gland [Term] id: UBERON:0003585 name: dermis connective tissue def: "A portion of connective tissue that is part of a dermis [Automatically generated definition]." [OBOL:automatic] subset: pheno_slim synonym: "connective tissue of dermis" EXACT [OBOL:automatic] synonym: "dermis portion of connective tissue" EXACT [OBOL:automatic] synonym: "dermis textus connectivus" EXACT [OBOL:automatic] synonym: "portion of connective tissue of dermis" EXACT [OBOL:automatic] synonym: "textus connectivus of dermis" EXACT [OBOL:automatic] xref: EMAPA:36509 xref: MA:0000799 is_a: UBERON:0002384 ! connective tissue is_a: UBERON:0010313 ! neural crest-derived structure intersection_of: UBERON:0002384 ! connective tissue intersection_of: BFO:0000050 UBERON:0002067 ! part of dermis relationship: BFO:0000050 UBERON:0002067 ! part of dermis relationship: RO:0002202 UBERON:0004016 ! develops from dermatome property_value: skos:prefLabel "dermis connective tissue" xsd:string [Term] id: UBERON:0003586 name: trunk connective tissue def: "A portion of connective tissue that is part of a trunk [Automatically generated definition]." [OBOL:automatic] synonym: "connective tissue of torso" EXACT [OBOL:automatic] synonym: "connective tissue of trunk" EXACT [OBOL:automatic] synonym: "portion of connective tissue of torso" EXACT [OBOL:automatic] synonym: "portion of connective tissue of trunk" EXACT [OBOL:automatic] synonym: "textus connectivus of torso" EXACT [OBOL:automatic] synonym: "textus connectivus of trunk" EXACT [OBOL:automatic] synonym: "torso connective tissue" EXACT [OBOL:automatic] synonym: "torso portion of connective tissue" EXACT [OBOL:automatic] synonym: "torso textus connectivus" EXACT [OBOL:automatic] synonym: "trunk portion of connective tissue" EXACT [OBOL:automatic] synonym: "trunk textus connectivus" EXACT [OBOL:automatic] xref: EMAPA:37252 {source="MA:th"} xref: MA:0000513 is_a: UBERON:0002384 ! connective tissue intersection_of: UBERON:0002384 ! connective tissue intersection_of: BFO:0000050 UBERON:0002100 ! part of trunk relationship: BFO:0000050 UBERON:0002100 ! part of trunk property_value: skos:prefLabel "trunk connective tissue" xsd:string [Term] id: UBERON:0003587 name: limb connective tissue def: "A portion of connective tissue that is part of a limb [Automatically generated definition]." [OBOL:automatic] synonym: "connective tissue of limb" EXACT [OBOL:automatic] synonym: "limb portion of connective tissue" EXACT [OBOL:automatic] synonym: "limb textus connectivus" EXACT [OBOL:automatic] synonym: "portion of connective tissue of limb" EXACT [OBOL:automatic] synonym: "textus connectivus of limb" EXACT [OBOL:automatic] xref: EMAPA:37313 {source="MA:th"} xref: MA:0000689 is_a: BFO:0000002 is_a: UBERON:0002384 ! connective tissue intersection_of: UBERON:0002384 ! connective tissue intersection_of: BFO:0000050 UBERON:0002101 ! part of limb relationship: BFO:0000050 UBERON:0002101 ! part of limb relationship: RO:0002494 UBERON:0009749 ! transformation of limb mesenchyme [Term] id: UBERON:0003588 name: forelimb connective tissue def: "A portion of connective tissue that is part of a forelimb [Automatically generated definition]." [OBOL:automatic] synonym: "connective tissue of anteriormost limb" EXACT [OBOL:automatic] synonym: "connective tissue of fore limb" EXACT [OBOL:automatic] synonym: "connective tissue of forelimb" EXACT [OBOL:automatic] synonym: "connective tissue of superior member" EXACT [OBOL:automatic] synonym: "connective tissue of upper extremity" EXACT [OBOL:automatic] synonym: "wing connective tissue" NARROW SENSU [NCBITaxon:8782, OBOL:automatic] xref: EMAPA:37314 {source="MA:th"} xref: MA:0000613 is_a: UBERON:0003587 ! limb connective tissue intersection_of: UBERON:0002384 ! connective tissue intersection_of: BFO:0000050 UBERON:0002102 ! part of forelimb relationship: BFO:0000050 UBERON:0002102 ! part of forelimb relationship: RO:0002494 UBERON:0003859 ! transformation of forelimb mesenchyme [Term] id: UBERON:0003589 name: hindlimb connective tissue def: "A portion of connective tissue that is part of a hindlimb [Automatically generated definition]." [OBOL:automatic] synonym: "connective tissue of hind limb" EXACT [OBOL:automatic] synonym: "connective tissue of hindlimb" EXACT [OBOL:automatic] synonym: "connective tissue of inferior member" EXACT [OBOL:automatic] synonym: "connective tissue of lower extremity" EXACT [OBOL:automatic] synonym: "hind limb connective tissue" EXACT [OBOL:automatic] xref: EMAPA:37322 {source="MA:th"} xref: MA:0000661 is_a: UBERON:0003587 ! limb connective tissue intersection_of: UBERON:0002384 ! connective tissue intersection_of: BFO:0000050 UBERON:0002103 ! part of hindlimb relationship: BFO:0000050 UBERON:0002103 ! part of hindlimb relationship: RO:0002494 UBERON:0003860 ! transformation of hindlimb mesenchyme [Term] id: UBERON:0003591 name: lobar bronchus connective tissue def: "A portion of connective tissue that is part of a lobar bronchus [Automatically generated definition]." [OBOL:automatic] subset: human_reference_atlas synonym: "connective tissue of lobar bronchus" EXACT [OBOL:automatic] synonym: "connective tissue of secondary bronchus" EXACT [OBOL:automatic] xref: EMAPA:37647 {source="MA:th"} xref: MA:0001841 is_a: UBERON:0000114 ! lung connective tissue is_a: UBERON:0003592 ! bronchus connective tissue intersection_of: UBERON:0002384 ! connective tissue intersection_of: BFO:0000050 UBERON:0002183 ! part of lobar bronchus relationship: BFO:0000050 UBERON:0002183 ! part of lobar bronchus relationship: RO:0002494 UBERON:0004884 ! transformation of lobar bronchus mesenchyme property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0003592 name: bronchus connective tissue def: "A portion of connective tissue that is part of a bronchus [Automatically generated definition]." [OBOL:automatic] synonym: "bronchi connective tissue" EXACT [OBOL:automatic] synonym: "bronchi portion of connective tissue" EXACT [OBOL:automatic] synonym: "bronchi textus connectivus" EXACT [OBOL:automatic] synonym: "bronchial connective tissue" RELATED [EMAPA:35193] synonym: "bronchial mesenchyme" RELATED [EMAPA:32690] synonym: "bronchial trunk connective tissue" EXACT [OBOL:automatic] synonym: "bronchial trunk portion of connective tissue" EXACT [OBOL:automatic] synonym: "bronchial trunk textus connectivus" EXACT [OBOL:automatic] synonym: "bronchus portion of connective tissue" EXACT [OBOL:automatic] synonym: "bronchus textus connectivus" EXACT [OBOL:automatic] synonym: "connective tissue of bronchi" EXACT [OBOL:automatic] synonym: "connective tissue of bronchial trunk" EXACT [OBOL:automatic] synonym: "connective tissue of bronchus" EXACT [OBOL:automatic] synonym: "portion of connective tissue of bronchi" EXACT [OBOL:automatic] synonym: "portion of connective tissue of bronchial trunk" EXACT [OBOL:automatic] synonym: "portion of connective tissue of bronchus" EXACT [OBOL:automatic] synonym: "textus connectivus of bronchi" EXACT [OBOL:automatic] synonym: "textus connectivus of bronchial trunk" EXACT [OBOL:automatic] synonym: "textus connectivus of bronchus" EXACT [OBOL:automatic] xref: EMAPA:32690 xref: EMAPA:35193 xref: MA:0001831 xref: NCIT:C49210 xref: UMLS:C1707052 {source="ncithesaurus:Bronchus_Connective_Tissue"} is_a: UBERON:0003580 ! lower respiratory tract connective tissue intersection_of: UBERON:0002384 ! connective tissue intersection_of: BFO:0000050 UBERON:0002185 ! part of bronchus relationship: BFO:0000050 UBERON:0002185 ! part of bronchus property_value: skos:prefLabel "bronchus connective tissue" xsd:string [Term] id: UBERON:0003593 name: thoracic cavity connective tissue def: "A portion of connective tissue that is part of a thoracic cavity [Automatically generated definition]." [OBOL:automatic] synonym: "cavity of chest connective tissue" EXACT [OBOL:automatic] synonym: "cavity of chest portion of connective tissue" EXACT [OBOL:automatic] synonym: "cavity of chest textus connectivus" EXACT [OBOL:automatic] synonym: "cavity of thorax connective tissue" EXACT [OBOL:automatic] synonym: "cavity of thorax portion of connective tissue" EXACT [OBOL:automatic] synonym: "cavity of thorax textus connectivus" EXACT [OBOL:automatic] synonym: "chest cavity connective tissue" EXACT [OBOL:automatic] synonym: "chest cavity portion of connective tissue" EXACT [OBOL:automatic] synonym: "chest cavity textus connectivus" EXACT [OBOL:automatic] synonym: "connective tissue of cavity of chest" EXACT [OBOL:automatic] synonym: "connective tissue of cavity of thorax" EXACT [OBOL:automatic] synonym: "connective tissue of chest cavity" EXACT [OBOL:automatic] synonym: "connective tissue of pectoral cavity" EXACT [OBOL:automatic] synonym: "connective tissue of thoracic cavity" EXACT [OBOL:automatic] synonym: "pectoral cavity connective tissue" EXACT [OBOL:automatic] synonym: "pectoral cavity portion of connective tissue" EXACT [OBOL:automatic] synonym: "pectoral cavity textus connectivus" EXACT [OBOL:automatic] synonym: "portion of connective tissue of cavity of chest" EXACT [OBOL:automatic] synonym: "portion of connective tissue of cavity of thorax" EXACT [OBOL:automatic] synonym: "portion of connective tissue of chest cavity" EXACT [OBOL:automatic] synonym: "portion of connective tissue of pectoral cavity" EXACT [OBOL:automatic] synonym: "portion of connective tissue of thoracic cavity" EXACT [OBOL:automatic] synonym: "textus connectivus of cavity of chest" EXACT [OBOL:automatic] synonym: "textus connectivus of cavity of thorax" EXACT [OBOL:automatic] synonym: "textus connectivus of chest cavity" EXACT [OBOL:automatic] synonym: "textus connectivus of pectoral cavity" EXACT [OBOL:automatic] synonym: "textus connectivus of thoracic cavity" EXACT [OBOL:automatic] synonym: "thoracic cavity portion of connective tissue" EXACT [OBOL:automatic] synonym: "thoracic cavity textus connectivus" EXACT [OBOL:automatic] xref: EMAPA:37255 {source="MA:th"} xref: MA:0000555 is_a: UBERON:0002384 ! connective tissue intersection_of: UBERON:0002384 ! connective tissue intersection_of: RO:0001025 UBERON:0002224 ! located in thoracic cavity relationship: RO:0001025 UBERON:0002224 ! located in thoracic cavity property_value: skos:prefLabel "thoracic cavity connective tissue" xsd:string [Term] id: UBERON:0003594 name: pelvis connective tissue def: "A portion of connective tissue that is part of a pelvis [Automatically generated definition]." [OBOL:automatic] synonym: "connective tissue of pelvis" EXACT [OBOL:automatic] synonym: "pelvis portion of connective tissue" EXACT [OBOL:automatic] synonym: "pelvis textus connectivus" EXACT [OBOL:automatic] synonym: "portion of connective tissue of pelvis" EXACT [OBOL:automatic] synonym: "textus connectivus of pelvis" EXACT [OBOL:automatic] xref: EMAPA:37257 {source="MA:th"} xref: MA:0000533 is_a: UBERON:0003838 ! abdominal segment connective tissue intersection_of: UBERON:0002384 ! connective tissue intersection_of: BFO:0000050 UBERON:0002355 ! part of pelvic region of trunk relationship: BFO:0000050 UBERON:0002355 ! part of pelvic region of trunk [Term] id: UBERON:0003595 name: pes connective tissue def: "A portion of connective tissue that is part of a foot [Automatically generated definition]." [OBOL:automatic] synonym: "connective tissue of foot" EXACT [OBOL:automatic] synonym: "connective tissue of terminal segment of free lower limb" EXACT [OBOL:automatic] synonym: "foot connective tissue" EXACT [MA:0000644] synonym: "textus connectivus of pes" EXACT OMO:0003011 [OBOL:automatic] xref: EMAPA:37329 {source="MA:th"} xref: MA:0000644 is_a: UBERON:0003589 ! hindlimb connective tissue intersection_of: UBERON:0002384 ! connective tissue intersection_of: BFO:0000050 UBERON:0002387 ! part of pes relationship: BFO:0000050 UBERON:0002387 ! part of pes relationship: RO:0002494 UBERON:0003328 ! transformation of mesenchyme of footplate [Term] id: UBERON:0003596 name: ankle connective tissue def: "A portion of connective tissue that is part of an ankle [Automatically generated definition]." [OBOL:automatic] synonym: "connective tissue of ankle" EXACT [OBOL:automatic] synonym: "tarsal region connective tissue" EXACT [https://orcid.org/0000-0002-6601-2165] xref: EMAPA:37328 {source="MA:th"} xref: MA:0000639 is_a: UBERON:0003595 ! pes connective tissue intersection_of: UBERON:0002384 ! connective tissue intersection_of: BFO:0000050 UBERON:0004454 ! part of tarsal region relationship: BFO:0000050 UBERON:0004454 ! part of tarsal region relationship: RO:0002494 UBERON:0010695 ! transformation of mesenchyme of tarsal region [Term] id: UBERON:0003597 name: manual digit connective tissue def: "A portion of connective tissue that is part of a finger [Automatically generated definition]." [OBOL:automatic] synonym: "connective tissue of digit of hand" EXACT [OBOL:automatic] synonym: "connective tissue of digitus manus" EXACT [OBOL:automatic] synonym: "connective tissue of finger" EXACT [OBOL:automatic] synonym: "connective tissue of hand digit" EXACT [OBOL:automatic] synonym: "fore limb digit connective tissue" EXACT [OBOL:accepted] synonym: "hand digit connective tissue" EXACT [MA:0000623] synonym: "hand digit connective tissue" NARROW SENSU [NCBITaxon:9606, OBOL:accepted] xref: EMAPA:37321 {source="MA:th"} xref: MA:0000623 is_a: UBERON:0003598 ! manus connective tissue is_a: UBERON:0015791 ! digit connective tissue intersection_of: UBERON:0002384 ! connective tissue intersection_of: BFO:0000050 UBERON:0002389 ! part of manual digit relationship: BFO:0000050 UBERON:0002389 ! part of manual digit relationship: RO:0002494 UBERON:0005257 ! transformation of manual digit mesenchyme [Term] id: UBERON:0003598 name: manus connective tissue def: "A portion of connective tissue that is part of a hand [Automatically generated definition]." [OBOL:automatic] synonym: "connective tissue of hand" EXACT [OBOL:automatic] synonym: "connective tissue of terminal segment of free upper limb" EXACT [OBOL:automatic] synonym: "hand connective tissue" EXACT [MA:0000620] xref: EMAPA:35392 xref: MA:0000620 is_a: UBERON:0003588 ! forelimb connective tissue intersection_of: UBERON:0002384 ! connective tissue intersection_of: BFO:0000050 UBERON:0002398 ! part of manus relationship: BFO:0000050 UBERON:0002398 ! part of manus relationship: RO:0002494 UBERON:0009523 ! transformation of mesenchyme of handplate [Term] id: UBERON:0003599 name: tail connective tissue def: "A portion of connective tissue that is part of a tail [Automatically generated definition]." [OBOL:automatic] synonym: "connective tissue of post-vent region" EXACT [OBOL:automatic] synonym: "connective tissue of tail" EXACT [OBOL:automatic] synonym: "portion of connective tissue of post-vent region" EXACT [OBOL:automatic] synonym: "portion of connective tissue of tail" EXACT [OBOL:automatic] synonym: "post-vent region connective tissue" EXACT [OBOL:automatic] synonym: "post-vent region portion of connective tissue" EXACT [OBOL:automatic] synonym: "post-vent region textus connectivus" EXACT [OBOL:automatic] synonym: "tail portion of connective tissue" EXACT [OBOL:automatic] synonym: "tail textus connectivus" EXACT [OBOL:automatic] synonym: "textus connectivus of post-vent region" EXACT [OBOL:automatic] synonym: "textus connectivus of tail" EXACT [OBOL:automatic] xref: EMAPA:16749 xref: MA:0000697 is_a: UBERON:0002384 ! connective tissue intersection_of: UBERON:0002384 ! connective tissue intersection_of: BFO:0000050 UBERON:0007812 ! part of post-anal tail relationship: BFO:0000050 UBERON:0007812 ! part of post-anal tail property_value: skos:prefLabel "tail connective tissue" xsd:string [Term] id: UBERON:0003601 name: neck cartilage def: "A cartilage that is part of a neck [Automatically generated definition]." [OBOL:automatic] synonym: "cartilage of neck" EXACT [OBOL:automatic] synonym: "cartilage of neck (volume)" EXACT [OBOL:automatic] synonym: "neck (volume) cartilage" EXACT [OBOL:automatic] xref: EMAPA:37251 {source="MA:th"} xref: MA:0000586 is_a: UBERON:0007844 ! cartilage element intersection_of: UBERON:0007844 ! cartilage element intersection_of: BFO:0000050 UBERON:0000974 ! part of neck relationship: BFO:0000050 UBERON:0000974 ! part of neck property_value: skos:prefLabel "neck cartilage" xsd:string [Term] id: UBERON:0003603 name: lower respiratory tract cartilage def: "A cartilage that is part of a lower respiratory tract [Automatically generated definition]." [OBOL:automatic] synonym: "cartilage of lower respiratory tract" EXACT [OBOL:automatic] xref: EMAPA:37547 {source="MA:th"} xref: MA:0001819 xref: NCIT:C49256 xref: UMLS:C1708759 {source="ncithesaurus:Lower_Respiratory_Tract_Cartilage"} is_a: UBERON:0003406 ! cartilage of respiratory system intersection_of: UBERON:0007844 ! cartilage element intersection_of: BFO:0000050 UBERON:0001558 ! part of lower respiratory tract relationship: BFO:0000050 UBERON:0001558 ! part of lower respiratory tract property_value: skos:prefLabel "lower respiratory tract cartilage" xsd:string [Term] id: UBERON:0003604 name: trachea cartilage def: "The ring-shaped cartilaginous structures that support the trachea." [http://orcid.org/0000-0002-6601-2165, J:97123, MGI:smb, MP:0003120] subset: human_reference_atlas subset: pheno_slim synonym: "cartilage of the trachea" RELATED [Wikipedia:Tracheal_rings] synonym: "cartilage of trachea" EXACT [OBOL:automatic] synonym: "cartilage of windpipe" EXACT [OBOL:automatic] synonym: "cartilagines tracheales" RELATED OMO:0003011 [Wikipedia:Tracheal_rings] synonym: "cartilaginous ring of trachea" EXACT [EMAPA:18699] synonym: "cartilaginous trachea cartilage" EXACT [OBOL:automatic] synonym: "cartilago trachealis" EXACT [FMA:7434] synonym: "ring of the trachea" RELATED [Wikipedia:Tracheal_rings] synonym: "trachea ring" RELATED [] synonym: "tracheal cartilage" EXACT [FMA:7434] synonym: "tracheal ring" RELATED [Wikipedia:Tracheal_rings] synonym: "windpipe cartilage" EXACT [OBOL:automatic] xref: EMAPA:18699 xref: EMAPA:35875 xref: FMA:7434 xref: MA:0001857 xref: NCIT:C49304 xref: SCTID:278979006 xref: UMLS:C1710456 {source="ncithesaurus:Trachea_Cartilage"} xref: Wikipedia:Tracheal_rings is_a: UBERON:0003603 ! lower respiratory tract cartilage intersection_of: UBERON:0007844 ! cartilage element intersection_of: BFO:0000050 UBERON:0003126 ! part of trachea relationship: BFO:0000050 UBERON:0003126 ! part of trachea relationship: RO:0002202 UBERON:0007267 ! develops from trachea pre-cartilage rings property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/5/56/Gray952.png" xsd:anyURI property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/trachea-female/v1.1/assets/3d-vh-f-trachea.glb" xsd:anyURI property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/trachea-male/v1.1/assets/3d-vh-m-trachea.glb" xsd:anyURI property_value: IAO:0000116 "check whether to classify as part of splanchoncranium" xsd:string property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "trachea cartilage" xsd:string [Term] id: UBERON:0003605 name: eye skin gland def: "A skin gland that is part of a camera-type eye [Automatically generated definition]." [OBOL:automatic] subset: organ_slim synonym: "camera-type eye skin gland" EXACT [OBOL:automatic] synonym: "camera-type eye skin glands" EXACT [OBOL:automatic] synonym: "camera-type eye skin glands set" EXACT [OBOL:automatic] synonym: "skin gland of camera-type eye" EXACT [OBOL:automatic] synonym: "skin gland of vertebrate eye" EXACT [OBOL:automatic] synonym: "skin glands of camera-type eye" EXACT [OBOL:automatic] synonym: "skin glands of vertebrate eye" EXACT [OBOL:automatic] synonym: "skin glands set of camera-type eye" EXACT [OBOL:automatic] synonym: "skin glands set of vertebrate eye" EXACT [OBOL:automatic] synonym: "vertebrate eye skin gland" EXACT [OBOL:automatic] synonym: "vertebrate eye skin glands" EXACT [OBOL:automatic] synonym: "vertebrate eye skin glands set" EXACT [OBOL:automatic] xref: EMAPA:37530 {source="MA:th"} xref: MA:0002451 is_a: UBERON:0002419 ! skin gland is_a: UBERON:0004859 ! eye gland is_a: UBERON:0015152 ! gland of ocular region intersection_of: UBERON:0002419 ! skin gland intersection_of: BFO:0000050 UBERON:0000019 ! part of camera-type eye relationship: BFO:0000050 UBERON:0000019 ! part of camera-type eye property_value: skos:prefLabel "eye skin gland" xsd:string [Term] id: UBERON:0003606 name: limb long bone def: "A long bone that is part of a limb [Automatically generated definition]." [OBOL:automatic] subset: pheno_slim synonym: "long bone of limb" EXACT [OBOL:automatic] xref: EMAPA:35495 xref: MA:0000298 is_a: UBERON:0002428 ! limb bone is_a: UBERON:0002495 ! long bone intersection_of: UBERON:0002495 ! long bone intersection_of: BFO:0000050 UBERON:0002101 ! part of limb [Term] id: UBERON:0003607 name: forelimb long bone def: "A long bone that is part of a forelimb [Automatically generated definition]." [OBOL:automatic] synonym: "anteriormost limb long bone" EXACT [OBOL:automatic] synonym: "fore limb long bone" EXACT [OBOL:automatic] synonym: "long bone of anteriormost limb" EXACT [OBOL:automatic] synonym: "long bone of fore limb" EXACT [OBOL:automatic] synonym: "long bone of forelimb" EXACT [OBOL:automatic] synonym: "long bone of superior member" EXACT [OBOL:automatic] synonym: "long bone of upper extremity" EXACT [OBOL:automatic] synonym: "superior member long bone" EXACT [OBOL:automatic] synonym: "upper extremity long bone" EXACT [OBOL:automatic] synonym: "wing long bone" NARROW SENSU [NCBITaxon:8782, OBOL:automatic] xref: EMAPA:35350 xref: MA:0000299 is_a: UBERON:0003606 ! limb long bone is_a: UBERON:0008962 ! forelimb bone intersection_of: UBERON:0002495 ! long bone intersection_of: BFO:0000050 UBERON:0002102 ! part of forelimb [Term] id: UBERON:0003608 name: hindlimb long bone def: "A long bone that is part of a hindlimb [Automatically generated definition]." [OBOL:automatic] synonym: "hind limb long bone" EXACT [OBOL:automatic] synonym: "inferior member long bone" EXACT [OBOL:automatic] synonym: "long bone of hind limb" EXACT [OBOL:automatic] synonym: "long bone of hindlimb" EXACT [OBOL:automatic] synonym: "long bone of inferior member" EXACT [OBOL:automatic] synonym: "long bone of lower extremity" EXACT [OBOL:automatic] synonym: "lower extremity long bone" EXACT [OBOL:automatic] xref: EMAPA:35403 xref: MA:0000300 is_a: UBERON:0003464 ! hindlimb bone is_a: UBERON:0003606 ! limb long bone intersection_of: UBERON:0002495 ! long bone intersection_of: BFO:0000050 UBERON:0002103 ! part of hindlimb [Term] id: UBERON:0003609 name: aorta elastic tissue def: "The dense connective tissue which contains predominantly elastic fibers and is found in the tunica media of the aorta wall." [MP:0009862] subset: pheno_slim synonym: "adult aorta elastic connective tissue" EXACT [OBOL:automatic] synonym: "adult aorta elastic tissue" EXACT [OBOL:automatic] synonym: "adult aorta textus connectivus elasticus" EXACT [OBOL:automatic] synonym: "aorta elastic connective tissue" EXACT [OBOL:automatic] synonym: "aorta elastic lamina" EXACT [MP:0009862] synonym: "aorta elastic laminae" EXACT OMO:0003004 [MP:0009862] synonym: "aorta textus connectivus elasticus" EXACT [OBOL:automatic] synonym: "dorsal aorta elastic connective tissue" EXACT [OBOL:automatic] synonym: "dorsal aorta elastic tissue" EXACT [OBOL:automatic] synonym: "dorsal aorta textus connectivus elasticus" EXACT [OBOL:automatic] synonym: "elastic connective tissue of adult aorta" EXACT [OBOL:automatic] synonym: "elastic connective tissue of aorta" EXACT [OBOL:automatic] synonym: "elastic connective tissue of dorsal aorta" EXACT [OBOL:automatic] synonym: "elastic connective tissue of trunk of aortic tree" EXACT [OBOL:automatic] synonym: "elastic tissue of adult aorta" EXACT [OBOL:automatic] synonym: "elastic tissue of aorta" EXACT [OBOL:automatic] synonym: "elastic tissue of dorsal aorta" EXACT [OBOL:automatic] synonym: "elastic tissue of trunk of aortic tree" EXACT [OBOL:automatic] synonym: "textus connectivus elasticus of adult aorta" EXACT [OBOL:automatic] synonym: "textus connectivus elasticus of aorta" EXACT [OBOL:automatic] synonym: "textus connectivus elasticus of dorsal aorta" EXACT [OBOL:automatic] synonym: "textus connectivus elasticus of trunk of aortic tree" EXACT [OBOL:automatic] synonym: "trunk of aortic tree elastic connective tissue" EXACT [OBOL:automatic] synonym: "trunk of aortic tree elastic tissue" EXACT [OBOL:automatic] synonym: "trunk of aortic tree textus connectivus elasticus" EXACT [OBOL:automatic] xref: MA:0002859 is_a: UBERON:0003614 ! blood vessel elastic tissue intersection_of: UBERON:0002521 ! elastic tissue intersection_of: BFO:0000050 UBERON:0000947 ! part of aorta relationship: BFO:0000050 UBERON:0000947 ! part of aorta property_value: skos:prefLabel "aorta elastic tissue" xsd:string [Term] id: UBERON:0003610 name: heart elastic tissue def: "The type of heart connective tissue found in the endocardial layer that consists mainly of elastic fibers." [MP:0009863] subset: pheno_slim synonym: "cardiac elastic tissue" EXACT [MP:0009863] synonym: "elastic connective tissue of heart" EXACT [OBOL:automatic] synonym: "elastic tissue of heart" EXACT [OBOL:automatic] synonym: "heart elastic connective tissue" EXACT [OBOL:automatic] synonym: "heart textus connectivus elasticus" EXACT [OBOL:automatic] synonym: "textus connectivus elasticus of heart" EXACT [OBOL:automatic] xref: MA:0002858 is_a: UBERON:0003613 ! cardiovascular system elastic tissue is_a: UBERON:0003837 ! thoracic segment connective tissue intersection_of: UBERON:0002521 ! elastic tissue intersection_of: BFO:0000050 UBERON:0000948 ! part of heart relationship: BFO:0000050 UBERON:0000948 ! part of heart property_value: skos:prefLabel "heart elastic tissue" xsd:string [Term] id: UBERON:0003611 name: respiratory system elastic tissue def: "An elastic tissue that is part of a respiratory system [Automatically generated definition]." [OBOL:automatic] synonym: "apparatus respiratorius elastic connective tissue" EXACT [OBOL:automatic] synonym: "apparatus respiratorius elastic tissue" EXACT [OBOL:automatic] synonym: "apparatus respiratorius textus connectivus elasticus" EXACT [OBOL:automatic] synonym: "elastic connective tissue of apparatus respiratorius" EXACT [OBOL:automatic] synonym: "elastic connective tissue of respiratory system" EXACT [OBOL:automatic] synonym: "elastic tissue of apparatus respiratorius" EXACT [OBOL:automatic] synonym: "elastic tissue of respiratory system" EXACT [OBOL:automatic] synonym: "respiratory system elastic connective tissue" EXACT [OBOL:automatic] synonym: "respiratory system textus connectivus elasticus" EXACT [OBOL:automatic] synonym: "textus connectivus elasticus of apparatus respiratorius" EXACT [OBOL:automatic] synonym: "textus connectivus elasticus of respiratory system" EXACT [OBOL:automatic] xref: EMAPA:37579 {source="MA:th"} xref: MA:0001820 is_a: UBERON:0002521 ! elastic tissue is_a: UBERON:0003570 ! respiratory system connective tissue intersection_of: UBERON:0002521 ! elastic tissue intersection_of: BFO:0000050 UBERON:0001004 ! part of respiratory system relationship: BFO:0000050 UBERON:0004777 ! part of respiratory system submucosa property_value: skos:prefLabel "respiratory system elastic tissue" xsd:string [Term] id: UBERON:0003613 name: cardiovascular system elastic tissue def: "An elastic tissue that is part of a circulatory system [Automatically generated definition]." [OBOL:automatic] synonym: "cardiovascular system elastic connective tissue" EXACT [OBOL:automatic] synonym: "cardiovascular system textus connectivus elasticus" EXACT [OBOL:automatic] synonym: "circulatory system elastic connective tissue" EXACT [OBOL:automatic] synonym: "circulatory system elastic tissue" EXACT [OBOL:automatic] synonym: "circulatory system textus connectivus elasticus" EXACT [OBOL:automatic] synonym: "elastic connective tissue of cardiovascular system" EXACT [OBOL:automatic] synonym: "elastic connective tissue of circulatory system" EXACT [OBOL:automatic] synonym: "elastic tissue of cardiovascular system" EXACT [OBOL:automatic] synonym: "elastic tissue of circulatory system" EXACT [OBOL:automatic] synonym: "textus connectivus elasticus of cardiovascular system" EXACT [OBOL:automatic] synonym: "textus connectivus elasticus of circulatory system" EXACT [OBOL:automatic] xref: MA:0002857 is_a: UBERON:0002521 ! elastic tissue intersection_of: UBERON:0002521 ! elastic tissue intersection_of: BFO:0000050 UBERON:0001009 ! part of circulatory system relationship: BFO:0000050 UBERON:0004535 ! part of cardiovascular system property_value: skos:prefLabel "cardiovascular system elastic tissue" xsd:string [Term] id: UBERON:0003614 name: blood vessel elastic tissue def: "Elastic tissue layer that lines a blood vessel layer." [http://orcid.org/0000-0002-6601-2165, https://sourceforge.net/p/obo/mammalian-phenotype-requests/2026/] subset: pheno_slim synonym: "blood vessel elastic connective tissue" EXACT [OBOL:automatic] synonym: "blood vessel textus connectivus elasticus" EXACT [OBOL:automatic] synonym: "elastic connective tissue of blood vessel" EXACT [OBOL:automatic] synonym: "elastic lamina" BROAD [MP:0006083] synonym: "elastic laminae" BROAD OMO:0003004 [MP:0006083] synonym: "elastic tissue of blood vessel" EXACT [OBOL:automatic] synonym: "textus connectivus elasticus of blood vessel" EXACT [OBOL:automatic] synonym: "vascular elastic lamina" EXACT [http://orcid.org/0000-0002-6601-2165] synonym: "vascular elastic laminae" EXACT OMO:0003004 [http://orcid.org/0000-0002-6601-2165] synonym: "vascular elastic tissue" EXACT [MP:0006083] xref: EMAPA:36300 xref: MA:0002856 is_a: UBERON:0003613 ! cardiovascular system elastic tissue intersection_of: UBERON:0002521 ! elastic tissue intersection_of: BFO:0000050 UBERON:0001981 ! part of blood vessel relationship: BFO:0000050 UBERON:0001981 ! part of blood vessel property_value: skos:prefLabel "blood vessel elastic tissue" xsd:string [Term] id: UBERON:0003615 name: lung elastic tissue def: "Elastic tissue that is part of a lung [Automatically generated definition]." [OBOL:automatic] synonym: "elastic connective tissue of lung" EXACT [OBOL:automatic] synonym: "elastic tissue of lung" EXACT [OBOL:automatic] synonym: "lung elastic connective tissue" EXACT [OBOL:automatic] synonym: "lung textus connectivus elasticus" EXACT [OBOL:automatic] synonym: "pulmonary elastic fiber" NARROW [http://orcid.org/0000-0002-6601-2165] synonym: "textus connectivus elasticus of lung" EXACT [OBOL:automatic] xref: MA:0002860 is_a: UBERON:0000114 ! lung connective tissue is_a: UBERON:0003611 ! respiratory system elastic tissue intersection_of: UBERON:0002521 ! elastic tissue intersection_of: BFO:0000050 UBERON:0002048 ! part of lung property_value: skos:prefLabel "lung elastic tissue" xsd:string [Term] id: UBERON:0003616 name: bronchus elastic tissue def: "An elastic tissue that is part of a bronchus [Automatically generated definition]." [OBOL:automatic] synonym: "bronchi elastic connective tissue" EXACT [OBOL:automatic] synonym: "bronchi elastic tissue" EXACT [OBOL:automatic] synonym: "bronchi textus connectivus elasticus" EXACT [OBOL:automatic] synonym: "bronchial trunk elastic connective tissue" EXACT [OBOL:automatic] synonym: "bronchial trunk elastic tissue" EXACT [OBOL:automatic] synonym: "bronchial trunk textus connectivus elasticus" EXACT [OBOL:automatic] synonym: "bronchus elastic connective tissue" EXACT [OBOL:automatic] synonym: "bronchus textus connectivus elasticus" EXACT [OBOL:automatic] synonym: "elastic connective tissue of bronchi" EXACT [OBOL:automatic] synonym: "elastic connective tissue of bronchial trunk" EXACT [OBOL:automatic] synonym: "elastic connective tissue of bronchus" EXACT [OBOL:automatic] synonym: "elastic tissue of bronchi" EXACT [OBOL:automatic] synonym: "elastic tissue of bronchial trunk" EXACT [OBOL:automatic] synonym: "elastic tissue of bronchus" EXACT [OBOL:automatic] synonym: "textus connectivus elasticus of bronchi" EXACT [OBOL:automatic] synonym: "textus connectivus elasticus of bronchial trunk" EXACT [OBOL:automatic] synonym: "textus connectivus elasticus of bronchus" EXACT [OBOL:automatic] xref: MA:0001838 xref: NCIT:C49211 xref: UMLS:C1707053 {source="ncithesaurus:Bronchus_Elastic_Tissue"} is_a: UBERON:0003592 ! bronchus connective tissue is_a: UBERON:0003611 ! respiratory system elastic tissue intersection_of: UBERON:0002521 ! elastic tissue intersection_of: BFO:0000050 UBERON:0002185 ! part of bronchus relationship: BFO:0000050 UBERON:0001957 ! part of submucosa of bronchus property_value: skos:prefLabel "bronchus elastic tissue" xsd:string [Term] id: UBERON:0003617 name: trachea elastic tissue def: "An elastic tissue that is part of a trachea [Automatically generated definition]." [OBOL:automatic] subset: human_reference_atlas synonym: "cartilaginous trachea elastic connective tissue" EXACT [OBOL:automatic] synonym: "cartilaginous trachea elastic tissue" EXACT [OBOL:automatic] synonym: "cartilaginous trachea textus connectivus elasticus" EXACT [OBOL:automatic] synonym: "elastic connective tissue of cartilaginous trachea" EXACT [OBOL:automatic] synonym: "elastic connective tissue of vertebrate trachea" EXACT [OBOL:automatic] synonym: "elastic connective tissue of windpipe" EXACT [OBOL:automatic] synonym: "elastic tissue of cartilaginous trachea" EXACT [OBOL:automatic] synonym: "elastic tissue of vertebrate trachea" EXACT [OBOL:automatic] synonym: "elastic tissue of windpipe" EXACT [OBOL:automatic] synonym: "textus connectivus elasticus of cartilaginous trachea" EXACT [OBOL:automatic] synonym: "textus connectivus elasticus of vertebrate trachea" EXACT [OBOL:automatic] synonym: "textus connectivus elasticus of windpipe" EXACT [OBOL:automatic] synonym: "vertebrate trachea elastic connective tissue" EXACT [OBOL:automatic] synonym: "vertebrate trachea elastic tissue" EXACT [OBOL:automatic] synonym: "vertebrate trachea textus connectivus elasticus" EXACT [OBOL:automatic] synonym: "windpipe elastic connective tissue" EXACT [OBOL:automatic] synonym: "windpipe elastic tissue" EXACT [OBOL:automatic] synonym: "windpipe textus connectivus elasticus" EXACT [OBOL:automatic] xref: MA:0001861 is_a: UBERON:0003571 ! trachea connective tissue is_a: UBERON:0003611 ! respiratory system elastic tissue intersection_of: UBERON:0002521 ! elastic tissue intersection_of: BFO:0000050 UBERON:0003126 ! part of trachea relationship: BFO:0000050 UBERON:0002202 ! part of submucosa of trachea property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "trachea elastic tissue" xsd:string [Term] id: UBERON:0003618 name: aorta tunica media def: "The middle layer of the aorta wall, containing the smooth muscle layer and elastic fibers." [MP:0009873] subset: pheno_slim synonym: "adult aorta tunica media" EXACT [OBOL:automatic] synonym: "dorsal aorta tunica media" EXACT [OBOL:automatic] synonym: "trunk of aortic tree tunica media" EXACT [OBOL:automatic] synonym: "tunica media of adult aorta" EXACT [OBOL:automatic] synonym: "tunica media of aorta" EXACT [OBOL:automatic] synonym: "tunica media of dorsal aorta" EXACT [OBOL:automatic] synonym: "tunica media of trunk of aortic tree" EXACT [OBOL:automatic] xref: EMAPA:35138 xref: FMA:74433 xref: MA:0002903 xref: SCTID:48467007 is_a: UBERON:0002522 ! tunica media intersection_of: UBERON:0002522 ! tunica media intersection_of: BFO:0000050 UBERON:0000947 ! part of aorta relationship: BFO:0000050 UBERON:0004663 ! part of aorta wall relationship: RO:0002433 UBERON:0004663 ! contributes to morphology of aorta wall property_value: skos:prefLabel "aorta tunica media" xsd:string [Term] id: UBERON:0003619 name: aorta tunica intima def: "The innermost layer of the aorta, containing the endothelium and an inner elastic membrane." [MP:0009872] subset: pheno_slim synonym: "adult aorta tunica intima" EXACT [OBOL:automatic] synonym: "dorsal aorta tunica intima" EXACT [OBOL:automatic] synonym: "trunk of aortic tree tunica intima" EXACT [OBOL:automatic] synonym: "tunica intima of adult aorta" EXACT [OBOL:automatic] synonym: "tunica intima of aorta" EXACT [OBOL:automatic] synonym: "tunica intima of dorsal aorta" EXACT [OBOL:automatic] synonym: "tunica intima of trunk of aortic tree" EXACT [OBOL:automatic] xref: BTO:0005553 xref: EMAPA:35137 xref: FMA:74419 xref: MA:0002904 xref: SCTID:362031007 is_a: UBERON:0002523 ! tunica intima is_a: UBERON:0004797 ! blood vessel layer intersection_of: UBERON:0002523 ! tunica intima intersection_of: BFO:0000050 UBERON:0000947 ! part of aorta relationship: BFO:0000050 UBERON:0004663 ! part of aorta wall relationship: RO:0002433 UBERON:0004663 ! contributes to morphology of aorta wall property_value: skos:prefLabel "aorta tunica intima" xsd:string [Term] id: UBERON:0003643 name: respiratory system arterial blood vessel def: "An arterial blood vessel that is part of a respiratory system [Automatically generated definition]." [OBOL:automatic] xref: EMAPA:37565 {source="MA:th"} xref: MA:0001800 is_a: UBERON:0003504 ! respiratory system blood vessel is_a: UBERON:0003509 ! arterial blood vessel intersection_of: UBERON:0003509 ! arterial blood vessel intersection_of: BFO:0000050 UBERON:0001004 ! part of respiratory system property_value: skos:prefLabel "respiratory system arterial blood vessel" xsd:string [Term] id: UBERON:0003644 name: kidney arterial blood vessel def: "An arterial blood vessel that is part of a kidney [Automatically generated definition]." [OBOL:automatic] subset: pheno_slim synonym: "kidney arterial system" RELATED [EMAPA:31436] xref: EMAPA:31436 xref: MA:0002578 is_a: UBERON:0003509 ! arterial blood vessel is_a: UBERON:0003517 ! kidney blood vessel intersection_of: UBERON:0003509 ! arterial blood vessel intersection_of: BFO:0000050 UBERON:0002113 ! part of kidney [Term] id: UBERON:0003656 name: mesopodium bone def: "A bone that is part of a mesopodial skeleton." [https://orcid.org/0000-0002-6601-2165] synonym: "basipodium bone" EXACT [MA:th] synonym: "carpal/tarsal bone" EXACT [MA:0000295] synonym: "mesopod bone" EXACT [] synonym: "mesopodial bone" EXACT [] xref: EMAPA:36579 xref: MA:0000295 xref: Wikipedia:Carpus_and_tarsus_of_land_vertebrates is_a: UBERON:0011250 ! autopod bone is_a: UBERON:0013630 {source="UBERON:cjm"} ! short bone intersection_of: UBERON:0001474 ! bone element intersection_of: BFO:0000050 UBERON:0006716 ! part of mesopodium region relationship: BFO:0000050 UBERON:0009878 ! part of mesopodial skeleton [Term] id: UBERON:0003657 name: limb joint def: "Any joint that is part of a (free) limb." [https://orcid.org/0000-0002-6601-2165] comment: Most limb joints are synovial, but a few such as the tibiofibular joints are syndesmoses subset: grouping_class synonym: "joint of limb" EXACT [] synonym: "joint of limb skeletal system" EXACT [OBOL:automatic] synonym: "skeletal limb joint" EXACT [GO:0036023] xref: EMAPA:36501 xref: FMA:321558 xref: galen:LimbJoint xref: MA:0000691 xref: SCTID:312683002 is_a: UBERON:0000982 ! skeletal joint intersection_of: UBERON:0000982 ! skeletal joint intersection_of: BFO:0000050 UBERON:0002101 ! part of limb relationship: BFO:0000050 UBERON:0002101 ! part of limb [Term] id: UBERON:0003658 name: hip muscle def: "Any muscle organ that is part of a hip [Automatically generated definition]." [OBOL:automatic] synonym: "hip muscle organ" EXACT [OBOL:automatic] synonym: "hip region muscle organ" EXACT [OBOL:automatic] synonym: "muscle organ of hip" EXACT [OBOL:automatic] synonym: "muscle organ of hip region" EXACT [OBOL:automatic] synonym: "muscle organ of regio coxae" EXACT [OBOL:automatic] synonym: "regio coxae muscle organ" EXACT [OBOL:automatic] xref: MA:0000657 is_a: UBERON:0010890 ! pelvic complex muscle intersection_of: UBERON:0014892 ! skeletal muscle organ, vertebrate intersection_of: BFO:0000050 UBERON:0001464 ! part of hip relationship: BFO:0000050 UBERON:0001464 ! part of hip relationship: BFO:0000050 UBERON:0004475 {source="prolog"} ! part of musculature of hip [Term] id: UBERON:0003659 name: pedal digit muscle def: "Any muscle organ that is part of a toe [Automatically generated definition]." [OBOL:automatic] synonym: "digit of foot muscle organ" EXACT [OBOL:automatic] synonym: "digit of terminal segment of free lower limb muscle organ" EXACT [OBOL:automatic] synonym: "digitus pedis muscle organ" EXACT [OBOL:automatic] synonym: "foot digit muscle" EXACT [MA:0000648] synonym: "foot digit muscle" NARROW SENSU [NCBITaxon:9606, OBOL:accepted] synonym: "foot digit muscle organ" EXACT [OBOL:automatic] synonym: "hind limb digit muscle" EXACT [OBOL:accepted] synonym: "muscle organ of digit of foot" EXACT [OBOL:automatic] synonym: "muscle organ of digit of terminal segment of free lower limb" EXACT [OBOL:automatic] synonym: "muscle organ of digitus pedis" EXACT [OBOL:automatic] synonym: "muscle organ of foot digit" EXACT [OBOL:automatic] synonym: "muscle organ of terminal segment of free lower limb digit" EXACT [OBOL:automatic] synonym: "muscle organ of toe" EXACT [OBOL:automatic] synonym: "terminal segment of free lower limb digit muscle organ" EXACT [OBOL:automatic] synonym: "toe muscle organ" EXACT [OBOL:automatic] xref: EMAPA:37333 {source="MA:th"} xref: MA:0000648 is_a: UBERON:0001498 ! muscle of pes intersection_of: UBERON:0014892 ! skeletal muscle organ, vertebrate intersection_of: BFO:0000050 UBERON:0001466 ! part of pedal digit relationship: BFO:0000050 UBERON:0001466 ! part of pedal digit [Term] id: UBERON:0003660 name: eyelid muscle def: "A muscle that attaches to an eyelid." [http://orcid.org/0000-0002-6601-2165] synonym: "blepharon muscle organ" EXACT [OBOL:automatic] synonym: "eyelid muscle organ" EXACT [OBOL:automatic] synonym: "muscle organ of blepharon" EXACT [OBOL:automatic] synonym: "muscle organ of eyelid" EXACT [OBOL:automatic] xref: MA:0000269 xref: NCIT:C52803 xref: UMLS:C1707990 {source="ncithesaurus:Eyelid_Muscle"} is_a: UBERON:0001630 ! muscle organ intersection_of: UBERON:0001630 ! muscle organ intersection_of: RO:0002371 UBERON:0001711 ! attached to eyelid relationship: RO:0002371 UBERON:0001711 ! attached to eyelid [Term] id: UBERON:0003661 name: limb muscle def: "Any muscle organ that is part of a limb [Automatically generated definition]." [OBOL:automatic] subset: human_reference_atlas subset: pheno_slim synonym: "limb muscle organ" EXACT [OBOL:accepted] synonym: "limb skeletal muscle" EXACT [OBOL:exploratory] synonym: "muscle organ of limb" EXACT [OBOL:accepted] xref: MA:0000692 is_a: UBERON:0014892 ! skeletal muscle organ, vertebrate intersection_of: UBERON:0014892 ! skeletal muscle organ, vertebrate intersection_of: BFO:0000050 UBERON:0002101 ! part of limb relationship: BFO:0000050 UBERON:0004480 {source="prolog"} ! part of musculature of limb relationship: RO:0002433 UBERON:0001015 ! contributes to morphology of musculature property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0003662 name: forelimb muscle def: "Any muscle organ that is part of a forelimb." [OBOL:automatic] synonym: "arm muscle system" RELATED [EHDAA2:0000141] synonym: "fore limb muscle organ" EXACT [OBOL:automatic] synonym: "forelimb muscle organ" EXACT [OBOL:automatic] synonym: "free upper limb muscle" EXACT [FMA:37348] synonym: "muscle of free upper limb" EXACT [FMA:37348] synonym: "muscle of upper limb" EXACT [FMA:9621] synonym: "musculature of arm" RELATED OMO:0003004 [] synonym: "musculature of the arm" RELATED OMO:0003004 [] synonym: "upper limb skeletal muscle" EXACT [http://orcid.org/0000-0002-6601-2165] synonym: "wing muscle" NARROW SENSU [Geisha:syn, NCBITaxon:8782, OBOL:automatic] xref: AAO:0000204 xref: BTO:0000479 xref: EMAPA:36049 xref: FMA:37348 is_a: UBERON:0003661 ! limb muscle is_a: UBERON:0014794 ! pectoral appendage muscle intersection_of: UBERON:0014892 ! skeletal muscle organ, vertebrate intersection_of: BFO:0000050 UBERON:0002102 ! part of forelimb relationship: BFO:0000050 UBERON:0004481 {source="prolog"} ! part of musculature of upper limb [Term] id: UBERON:0003663 name: hindlimb muscle def: "Any muscle organ that is part of a hindlimb [Automatically generated definition]." [OBOL:automatic] subset: efo_slim subset: human_reference_atlas synonym: "free lower limb muscle" EXACT [FMA:37368] synonym: "hind limb muscle organ" EXACT [OBOL:automatic] synonym: "hindlimb muscle organ" EXACT [OBOL:automatic] synonym: "inferior member muscle organ" EXACT [OBOL:automatic] synonym: "lower extremity muscle organ" EXACT [OBOL:automatic] synonym: "lower limb skeletal muscle" EXACT [http://orcid.org/0000-0002-6601-2165] synonym: "muscle of free lower limb" EXACT [FMA:37368] synonym: "muscle of posterior limb" EXACT [https://orcid.org/0000-0002-6601-2165] synonym: "muscle organ of hind limb" EXACT [OBOL:automatic] synonym: "muscle organ of hindlimb" EXACT [OBOL:automatic] synonym: "muscle organ of inferior member" EXACT [OBOL:automatic] synonym: "muscle organ of lower extremity" EXACT [OBOL:automatic] xref: AAO:0000222 xref: EFO:0001928 xref: FMA:37368 is_a: UBERON:0003661 ! limb muscle is_a: UBERON:0014795 ! pelvic appendage muscle intersection_of: UBERON:0014892 ! skeletal muscle organ, vertebrate intersection_of: BFO:0000050 UBERON:0002103 ! part of hindlimb relationship: BFO:0000050 UBERON:0004482 {source="prolog"} ! part of musculature of lower limb property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0003664 name: manual digit muscle def: "Any muscle organ that is part of a finger [Automatically generated definition]." [OBOL:automatic] synonym: "digit of hand muscle organ" EXACT [OBOL:automatic] synonym: "digit of terminal segment of free upper limb muscle organ" EXACT [OBOL:automatic] synonym: "digitus manus muscle organ" EXACT [OBOL:automatic] synonym: "finger muscle organ" EXACT [OBOL:automatic] synonym: "fore limb digit muscle" EXACT [OBOL:accepted] synonym: "hand digit muscle" EXACT [MA:0000624] synonym: "hand digit muscle" NARROW SENSU [NCBITaxon:9606, OBOL:accepted] synonym: "hand digit muscle organ" EXACT [OBOL:automatic] synonym: "muscle organ of digit of hand" EXACT [OBOL:automatic] synonym: "muscle organ of digit of terminal segment of free upper limb" EXACT [OBOL:automatic] synonym: "muscle organ of digitus manus" EXACT [OBOL:automatic] synonym: "muscle organ of finger" EXACT [OBOL:automatic] synonym: "muscle organ of hand digit" EXACT [OBOL:automatic] synonym: "muscle organ of terminal segment of free upper limb digit" EXACT [OBOL:automatic] synonym: "terminal segment of free upper limb digit muscle organ" EXACT [OBOL:automatic] xref: EMAPA:37331 {source="MA:th"} xref: MA:0000624 is_a: UBERON:0001500 ! muscle of manus intersection_of: UBERON:0014892 ! skeletal muscle organ, vertebrate intersection_of: BFO:0000050 UBERON:0002389 ! part of manual digit relationship: BFO:0000050 UBERON:0002389 ! part of manual digit [Term] id: UBERON:0003665 name: post-anal tail muscle def: "A muscle organ that attaches to a tail vertebra [Automatically generated definition]." [OBOL:automatic] synonym: "caudal muscle" EXACT [] synonym: "muscle organ of post-vent region" EXACT [OBOL:automatic] synonym: "muscle organ of tail" EXACT [OBOL:automatic] synonym: "post-vent region muscle organ" EXACT [OBOL:automatic] synonym: "tail muscle" EXACT [MA:0000699] synonym: "tail muscle organ" EXACT [OBOL:automatic] xref: AAO:0000081 xref: BTO:0001905 xref: EMAPA:37759 {source="MA:th"} xref: MA:0000699 xref: SCTID:113230005 is_a: UBERON:0004518 ! muscle of vertebral column intersection_of: UBERON:0014892 ! skeletal muscle organ, vertebrate intersection_of: RO:0002371 UBERON:0001095 ! attached to caudal vertebra relationship: RO:0002131 UBERON:0007812 ! overlaps post-anal tail relationship: RO:0002371 UBERON:0001095 ! attached to caudal vertebra property_value: skos:prefLabel "post-anal tail muscle" xsd:string [Term] id: UBERON:0003672 name: dentition def: "A collection of teeth arranged in some pattern in the mouth or other part of the body. The arrangement may be a simple row, a collection of rows, or a more elaborate structure, such as a toooth whorl." [http://orcid.org/0000-0002-6601-2165] subset: pheno_slim synonym: "collection of teeth" RELATED [] synonym: "dentes" EXACT OMO:0003011 [FMA:75150, FMA:TA] synonym: "set of teeth" EXACT [FMA:75150] synonym: "teeth" EXACT [FMA:75150] synonym: "teeth" RELATED [] synonym: "teeth set" EXACT [FMA:75150] xref: AAO:0000126 xref: FMA:75150 xref: GAID:1249 xref: MESH:D003817 xref: NCIT:C13072 xref: SCTID:245543004 xref: UMLS:C0011443 {source="ncithesaurus:Dentition"} is_a: BFO:0000002 is_a: BFO:0000004 is_a: UBERON:0034925 ! anatomical collection intersection_of: UBERON:0034925 ! anatomical collection intersection_of: RO:0002351 UBERON:0001091 ! has member calcareous tooth relationship: BFO:0000050 UBERON:0010323 ! part of cranial skeletal system relationship: RO:0002351 UBERON:0001091 ! has member calcareous tooth [Term] id: UBERON:0003677 name: tooth root def: "The part of a tooth that is implanted in the gum; the root is normally located below the neck of the tooth, covered by cementum rather than enamel, and attached by the periodontal ligament to the alveolar bone." [MP:0011165] subset: pheno_slim synonym: "radix corona" EXACT [FMA:55624] synonym: "root of tooth" EXACT [FMA:55624] synonym: "tooth root" EXACT [FMA:55624] xref: EMAPA:37975 {source="MA:th"} xref: FMA:55624 xref: GAID:1280 xref: MESH:D014092 xref: SCTID:245728004 is_a: UBERON:0000063 ! organ subunit relationship: BFO:0000050 UBERON:0001091 ! part of calcareous tooth relationship: RO:0002371 UBERON:0001091 ! attached to calcareous tooth [Term] id: UBERON:0003684 name: abdominal cavity def: "The part of the ventral body cavity that is within the abdomen proper (excluding the pelvic cavity)." [UBERON:cjm] subset: efo_slim synonym: "cavitas abdominis" RELATED OMO:0003011 [GAID:17, Wikipedia:Abdominal_cavity] synonym: "cavity of abdominal compartment" EXACT [FMA:12266] synonym: "cavity of compartment of abdomen" EXACT [FMA:12266] synonym: "space of abdominal compartment" EXACT [FMA:12266] xref: EFO:0000213 xref: EMAPA:36505 xref: FMA:12266 xref: GAID:17 xref: galen:AbdominalCavity xref: MA:0003057 xref: MESH:D034841 xref: NCIT:C12664 xref: SCTID:361294009 xref: UMLS:C0230168 {source="ncithesaurus:Abdominal_Cavity"} xref: Wikipedia:Abdominal_cavity is_a: UBERON:0000464 ! anatomical space intersection_of: UBERON:0000464 ! anatomical space intersection_of: BFO:0000050 UBERON:0002323 ! part of coelemic cavity lumen intersection_of: RO:0002572 UBERON:0000916 ! luminal space of abdomen relationship: BFO:0000050 UBERON:0035819 ! part of abdominopelvic cavity relationship: RO:0002572 UBERON:0000916 ! luminal space of abdomen property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/e/ee/Scheme_body_cavities-en.svg" xsd:anyURI property_value: skos:prefLabel "abdominal cavity" xsd:string [Term] id: UBERON:0003685 name: cranial suture def: "Fibrous joint in which the articulating bones or cartilages of the skull are connected by sutural ligaments (scant amount of collagenous dense connective tissue). Examples: sagittal suture, frontal suture." [FMA:71385, ISBN:3110148986, Wikipedia:Suture_(joint)] subset: pheno_slim subset: uberon_slim synonym: "cranium suture" EXACT [OBOL:automatic] synonym: "sutura" BROAD [] synonym: "suture" BROAD [FMA:71385] synonym: "suture joint of skull" EXACT [] synonym: "suture of cranium" EXACT [OBOL:automatic] xref: EMAPA:35263 xref: FMA:7493 xref: GAID:211 xref: MA:0001475 xref: MESH:D003393 xref: SCTID:244509003 xref: Wikipedia:Suture_(joint) is_a: UBERON:0009198 {source="GO"} ! craniofacial suture intersection_of: UBERON:0002209 ! fibrous joint intersection_of: BFO:0000050 UBERON:0003128 ! part of cranium relationship: BFO:0000050 UBERON:0003128 ! part of cranium relationship: RO:0002433 UBERON:0003128 ! contributes to morphology of cranium property_value: skos:prefLabel "cranial suture" xsd:string [Term] id: UBERON:0003687 name: foramen magnum def: "In anatomy, in the occipital bone, the foramen magnum is one of the several oval or circular apertures in the base of the skull, through which the medulla oblongata (an extension of the spinal cord) enters and exits the skull vault. Apart from the transmission of the medulla oblongata and its membranes, the foramen magnum transmits the Spinal Accessory nerve, vertebral arteries, the anterior and posterior spinal arteries, the membrana tectoria and alar ligaments. [WP,unvetted]." [Wikipedia:Foramen_magnum] comment: Design pattern notes: check whether this fits the foramen design pattern subset: pheno_slim subset: vertebrate_core xref: AAO:0010826 xref: EMAPA:37868 {source="MA:th"} xref: FMA:75306 xref: GAID:228 xref: MESH:D005539 xref: NCIT:C12495 xref: SCTID:244679008 xref: TAO:0002045 xref: UMLS:C0016519 {source="ncithesaurus:Foramen_Magnum"} xref: Wikipedia:Foramen_magnum xref: ZFA:0005387 is_a: UBERON:0013685 ! foramen of skull intersection_of: UBERON:0013685 ! foramen of skull intersection_of: RO:0002570 UBERON:0001896 ! conduit for medulla oblongata relationship: RO:0001025 UBERON:0001676 ! located in occipital bone relationship: RO:0002570 UBERON:0001896 ! conduit for medulla oblongata property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/3/39/Gray130.png" xsd:anyURI property_value: skos:prefLabel "foramen magnum" xsd:string [Term] id: UBERON:0003688 name: omentum def: "A fold of peritoneum originating at the stomach and supporting the viscera." [ncithesaurus:Omentum] xref: CALOHA:TS-2004 xref: EV:0100084 xref: FMA:14650 xref: GAID:23 xref: galen:Omentum xref: MESH:D009852 xref: NCIT:C33209 xref: SCTID:362710002 xref: UMLS:C0028977 {source="ncithesaurus:Omentum"} is_a: UBERON:0034944 ! zone of organ relationship: BFO:0000050 UBERON:0001178 ! part of visceral peritoneum [Term] id: UBERON:0003691 name: epidural space def: "The outermost part of the spinal canal. It is the space within the canal (formed by the surrounding vertebrae) lying outside the dura mater." [Wikipedia:Epidural_space] synonym: "cavum epidurale" EXACT OMO:0003011 [Wikipedia:Epidural_space] synonym: "cavum extradurale" EXACT OMO:0003011 [Wikipedia:Epidural_space] synonym: "epidural cavity" RELATED [Wikipedia:Epidural_space] synonym: "extradural space" EXACT [FMA:71228] synonym: "spatium epidurale" EXACT OMO:0003011 [Wikipedia:Epidural_space] synonym: "spatium extradurale" EXACT OMO:0003011 [FMA:71228, FMA:TA] xref: FMA:71228 xref: GAID:243 xref: MESH:D004824 xref: SCTID:281866004 xref: Wikipedia:Epidural_space is_a: UBERON:0010276 ! space in vertebral column intersection_of: UBERON:0000464 ! anatomical space intersection_of: BFO:0000050 UBERON:0006692 ! part of vertebral canal intersection_of: RO:0002221 UBERON:0002363 ! surrounds dura mater relationship: BFO:0000050 UBERON:0006692 ! part of vertebral canal relationship: RO:0002221 UBERON:0002363 ! surrounds dura mater [Term] id: UBERON:0003692 name: acromioclavicular joint def: "Any joint connecting the acromonion of the scapula and clavicle." [http://orcid.org/0000-0002-6601-2165, Wikipedia:Acromioclavicular_joint] synonym: "acromioclavicular articulation" RELATED [Wikipedia:Acromioclavicular_joint] synonym: "articulatio acromioclavicularis" RELATED OMO:0003011 [Wikipedia:Acromioclavicular_joint] synonym: "scapuloclavicular articulation" RELATED [Wikipedia:Acromioclavicular_joint] xref: FMA:25898 xref: GAID:249 xref: MESH:D000173 xref: NCIT:C32047 xref: SCTID:182166001 xref: UMLS:C0001208 {source="ncithesaurus:Acromioclavicular_Joint"} xref: Wikipedia:Acromioclavicular_joint is_a: UBERON:0011108 {source="FMA"} ! synovial joint of pectoral girdle is_a: UBERON:0016884 ! shoulder joint intersection_of: UBERON:0000982 ! skeletal joint intersection_of: RO:0002176 UBERON:0001105 ! connects clavicle bone intersection_of: RO:0002176 UBERON:0002497 ! connects acromion relationship: RO:0002176 UBERON:0001105 ! connects clavicle bone relationship: RO:0002176 UBERON:0002497 ! connects acromion property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/3/3b/Gray326.png" xsd:anyURI [Term] id: UBERON:0003694 name: atlanto-axial joint def: "The Atlanto-axial joint is of a complicated nature, comprising no fewer than four distinct joints. There is a pivot articulation between the odontoid process of the axis and the ring formed by the anterior arch and the transverse ligament of the atlas." [Wikipedia:Atlanto-axial_joint] subset: pheno_slim synonym: "articulatio atlantoaxialis" RELATED [Wikipedia:Atlanto-axial_joint] synonym: "articulatio atlantoepistrophica" RELATED [Wikipedia:Atlanto-axial_joint] synonym: "atlanto axial joint" EXACT [GAID:250] synonym: "atlantoaxial" RELATED [Wikipedia:Atlanto-axial_joint] synonym: "atlantoaxial joint" EXACT [GAID:250] synonym: "lateral atlanto-axial joint" RELATED [Wikipedia:Atlanto-axial_joint] synonym: "median atlanto-axial joint" RELATED [Wikipedia:Atlanto-axial_joint] xref: FMA:25524 xref: GAID:250 xref: MESH:D001268 xref: NCIT:C32157 xref: SCTID:361832004 xref: UMLS:C0004168 {source="ncithesaurus:Atlanto-axial_Joint"} xref: Wikipedia:Atlanto-axial_joint is_a: UBERON:0000982 ! skeletal joint intersection_of: UBERON:0000982 ! skeletal joint intersection_of: RO:0002176 UBERON:0001092 ! connects vertebral bone 1 intersection_of: RO:0002176 UBERON:0001093 ! connects vertebral bone 2 relationship: BFO:0000050 UBERON:0011138 ! part of postcranial axial skeletal system relationship: RO:0002176 UBERON:0001092 ! connects vertebral bone 1 relationship: RO:0002176 UBERON:0001093 ! connects vertebral bone 2 property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/d/d4/Gray304.png" xsd:anyURI property_value: skos:prefLabel "atlanto-axial joint" xsd:string [Term] id: UBERON:0003695 name: metacarpophalangeal joint def: "The metacarpophalangeal joints (MCP) are of the condyloid kind, formed by the reception of the rounded heads of the metacarpal bones into shallow cavities on the proximal ends of the first phalanges, with the exception of that of the thumb, which presents more of the characters of a ginglymoid joint. Arthritis of the MCP is a distinguishing feature of Rheumatoid Arthritis, as opposed to the distal interphalangeal joint in osteoarthritis. [WP,unvetted]." [Wikipedia:Metacarpophalangeal_joint] subset: pheno_slim synonym: "articulationes metacarpophalangeae" RELATED OMO:0003011 [Wikipedia:Metacarpophalangeal_joint] synonym: "carpometacarpophalangeal joint" NARROW SENSU [NCBITaxon:8782] synonym: "knuckle" EXACT [https://orcid.org/0000-0001-5208-3432] synonym: "knuckles" EXACT OMO:0003004 [https://orcid.org/0000-0001-5208-3432] synonym: "metacarpal joint" BROAD [FMA:35246] synonym: "metacarpal phalangeal joint" RELATED [HP:0004294] synonym: "metacarpo-phalangeal joint" EXACT [MA:0000453] synonym: "MP joint" EXACT [FMA:35246] xref: EMAPA:19302 xref: FMA:35246 xref: GAID:255 xref: galen:MetacarpoPhalangealJoint xref: MA:0000453 xref: MESH:D008662 xref: NCIT:C33106 xref: SCTID:280995004 xref: SCTID:370651001 xref: UMLS:C0025525 {source="ncithesaurus:Metacarpophalangeal_Joint"} xref: Wikipedia:Metacarpophalangeal_joint is_a: UBERON:0001489 ! manus joint intersection_of: UBERON:0000982 ! skeletal joint intersection_of: RO:0002176 UBERON:0002234 ! connects proximal phalanx of manus intersection_of: RO:0002176 UBERON:0002374 ! connects metacarpal bone relationship: BFO:0000050 UBERON:0002389 ! part of manual digit relationship: RO:0002176 UBERON:0002234 ! connects proximal phalanx of manus relationship: RO:0002176 UBERON:0002374 ! connects metacarpal bone property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/5/53/Gray337.png" xsd:anyURI property_value: IAO:0000116 "we follow FMA in making these joints part of digits. We include carpometacarpophalangeal joint as a synonym - these joints connect to the carpometacarpus - this is not necessarily inconsistent with the relationship for this class to metacarpal bone, as the carpometacarpus could be considered to have a metacarpal as part" xsd:string [Term] id: UBERON:0003696 name: metatarsophalangeal joint def: "The metatarsophalangeal articulations are the joints between the metatarsal bones of the foot and the proximal bones of the toes . They are condyloid joints meaning an elliptical or rounded surface (of the metatarsal bones) come close to the shallow cavities (of the proximal phalanges). The ligaments are the plantar and two collateral." [Wikipedia:Metatarsophalangeal_articulations] synonym: "articulationes metatarsophalangeae" RELATED OMO:0003011 [Wikipedia:Metatarsophalangeal_articulations] synonym: "metatarsal joint" RELATED [FMA:35222] synonym: "metatarsal-phalangeal joint" EXACT [PHENOSCAPE:ad] synonym: "metatarsalphalangeal joint" RELATED [Wikipedia:Metatarsophalangeal_articulations] synonym: "metatarsophalangeal" RELATED [Wikipedia:Metatarsophalangeal_articulations] synonym: "metatarsophalangeal articulation" RELATED [Wikipedia:Metatarsophalangeal_articulations] xref: FMA:35222 xref: GAID:258 xref: galen:MetatarsoPhalangealJoint xref: MESH:D008683 xref: NCIT:C33108 xref: SCTID:239747005 xref: SCTID:302535003 xref: SCTID:370752004 xref: UMLS:C0025589 {source="ncithesaurus:Metatarsophalangeal_Joint"} xref: Wikipedia:Metatarsophalangeal_articulations is_a: UBERON:0001487 ! pes joint intersection_of: UBERON:0000982 ! skeletal joint intersection_of: RO:0002176 UBERON:0001448 ! connects metatarsal bone intersection_of: RO:0002176 UBERON:0003867 ! connects distal phalanx of pes relationship: BFO:0000050 UBERON:0001466 ! part of pedal digit relationship: RO:0002176 UBERON:0001448 ! connects metatarsal bone relationship: RO:0002176 UBERON:0003867 ! connects distal phalanx of pes property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/9/9e/Gray268.png" xsd:anyURI property_value: IAO:0000116 "we follow FMA in making these joints part of digits" xsd:string [Term] id: UBERON:0003697 name: abdominal wall def: "The tissues that surround the organs that are present within the abdominal cavity. The abdominal wall tissue is composed of layers of fat, parietal peritoneum, fascia, and muscles." [ncithesaurus:Abdominal_Wall] subset: pheno_slim synonym: "abdominal wall proper" RELATED [FMA:10429] synonym: "layers of the abdominal wall" RELATED [Wikipedia:Abdominal_wall] synonym: "paries abdominalis" EXACT [Wikipedia:Abdominal_wall] synonym: "paries abdominalis" RELATED OMO:0003011 [Wikipedia:Abdominal_wall] synonym: "wall of abdomen" EXACT [FMA:259054] synonym: "wall of abdomen proper" EXACT [FMA:10429] xref: EMAPA:37064 {source="MA:th"} xref: FMA:10429 xref: FMA:259054 xref: GAID:26 xref: MESH:D034861 xref: NCIT:C77608 xref: SCTID:181613000 xref: UMLS:C0836916 {source="ncithesaurus:Abdominal_Wall"} xref: Wikipedia:Abdominal_wall is_a: UBERON:0000060 ! anatomical wall intersection_of: UBERON:0000060 ! anatomical wall intersection_of: BFO:0000050 UBERON:0000916 ! part of abdomen relationship: BFO:0000050 UBERON:0000916 ! part of abdomen property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/e/ee/Scheme_body_cavities-en.svg" xsd:anyURI property_value: skos:prefLabel "abdominal wall" xsd:string [Term] id: UBERON:0003703 name: extrahepatic bile duct def: "Passages external to the liver for the conveyance of bile. These include the common bile duct and the common hepatic duct." [MESH:A03.159.183.079] subset: pheno_slim subset: vertebrate_core synonym: "bile duct extrahepatic part" RELATED [MA:0002659] synonym: "extrahepatic biliary system" RELATED [GAID:281] xref: FMA:14678 xref: GAID:281 xref: MA:0002659 xref: MESH:D017734 xref: NCIT:C32573 xref: SCTID:276158002 xref: UMLS:C0206187 {source="ncithesaurus:Extrahepatic_Bile_Duct"} is_a: UBERON:0002394 ! bile duct property_value: IAO:0000116 "includes all the cystic duct, all the common bile duct and the extrahapetic part of the hepatic duct" xsd:string property_value: skos:prefLabel "extrahepatic bile duct" xsd:string [Term] id: UBERON:0003704 name: intrahepatic bile duct def: "Passages within the liver for the conveyance of bile. Includes right and left hepatic ducts even though these may join outside the liver to form the common hepatic duct." [MESH:A03.159.183.158] subset: pheno_slim subset: vertebrate_core synonym: "bile duct intrahepatic part" EXACT [MA:0001630] synonym: "intrahepatic biliary system" RELATED [] xref: FMA:15766 xref: GAID:287 xref: MA:0001630 xref: MESH:D001653 xref: NCIT:C12677 xref: SCTID:362193005 xref: TAO:0005169 xref: UMLS:C0005401 {source="ncithesaurus:Intrahepatic_Bile_Duct"} xref: ZFA:0005169 is_a: UBERON:0002394 {source="FMA"} ! bile duct intersection_of: UBERON:0002394 ! bile duct intersection_of: BFO:0000050 UBERON:0002107 ! part of liver relationship: BFO:0000050 UBERON:0002107 {source="MA"} ! part of liver relationship: RO:0002433 UBERON:0002107 ! contributes to morphology of liver property_value: IAO:0000116 "includes the hepatic duct of the caudate lobe, and the intra- and inter- lobar bile ducts" xsd:string property_value: skos:prefLabel "intrahepatic bile duct" xsd:string [Term] id: UBERON:0003709 name: circle of Willis def: "A circle of arteries that supply blood to the brain. The Circle of Willis comprises the following arteries: Anterior cerebral artery (left and right); Anterior communicating artery; Internal carotid artery (left and right); Posterior cerebral artery (left and right); Posterior communicating artery (left and right).The basilar artery and middle cerebral arteries, supplying the brain, are also considered part of the circle." [Wikipedia:Circle_of_Willis] subset: pheno_slim synonym: "arterial circle" BROAD [Wikipedia:Circle_of_Willis] synonym: "arterial circle of Willis" EXACT [] synonym: "cerebral arterial circle" EXACT [GAID:486] synonym: "circulus arteriosus cerebri" RELATED OMO:0003011 [Wikipedia:Circle_of_Willis] synonym: "Willis circle" RELATED [GAID:486] xref: EHDAA2:0000252 xref: EHDAA:9758 xref: EMAPA:37829 {source="MA:th"} xref: FMA:50454 xref: GAID:486 xref: MESH:D002941 xref: neuronames:1468 xref: SCTID:362047009 xref: Wikipedia:Circle_of_Willis is_a: UBERON:0004573 ! systemic artery relationship: RO:0002131 UBERON:0007142 {source="FMA-modified"} ! overlaps left internal carotid artery relationship: RO:0002131 UBERON:0007143 {source="FMA-modified"} ! overlaps right internal carotid artery property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/2/2e/Circle_of_Willis_en.svg" xsd:anyURI property_value: skos:prefLabel "circle of Willis" xsd:string [Term] id: UBERON:0003711 name: brachiocephalic vein def: "The left and right brachiocephalic veins in the upper chest are formed by the union of each corresponding internal jugular vein and subclavian vein. This is at the level of the sternoclavicular joint. These great vessels merge to form the superior vena cava. The brachiocephalic veins are the major veins returning blood to the superior vena cava." [Wikipedia:Brachiocephalic_vein] subset: human_reference_atlas synonym: "brachiocephalic venous tree" EXACT [FMA:4723] synonym: "innomiate vein" RELATED [Wikipedia:Brachiocephalic_vein] synonym: "innominate trunk" RELATED [Wikipedia:Brachiocephalic_vein] synonym: "innominate vein" EXACT [FMA:4723] synonym: "innominate vein" RELATED [GAID:529, Wikipedia:Brachiocephalic_vein] synonym: "innominate veins" RELATED [Wikipedia:Brachiocephalic_vein] synonym: "vena brachiocephalica" RELATED OMO:0003011 [Wikipedia:Brachiocephalic_vein] synonym: "venae anonyma" RELATED OMO:0003011 [Wikipedia:Brachiocephalic_vein] xref: EHDAA2:0000182 xref: EHDAA:9868 xref: FMA:4723 xref: GAID:529 xref: galen:BrachiocephalicVein xref: MESH:D016121 xref: NCIT:C32816 xref: SCTID:181371003 xref: UMLS:C0006095 {source="ncithesaurus:Innominate_Vein"} xref: Wikipedia:Brachiocephalic_vein is_a: UBERON:0001638 ! vein relationship: BFO:0000050 UBERON:0007204 ! part of brachiocephalic vasculature relationship: RO:0002170 UBERON:0001585 ! connected to anterior vena cava property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/9/9e/Gray1174.png" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "brachiocephalic vein" xsd:string [Term] id: UBERON:0003712 name: cavernous sinus def: "The cavernous sinus (or lateral sellar compartment), within the human head, is a large collection of thin-walled veins creating a cavity bordered by the temporal bone of the skull and the sphenoid bone, lateral to the sella turcica." [Wikipedia:Cavernous_sinus] subset: human_reference_atlas synonym: "cavernous" RELATED [Wikipedia:Cavernous_sinus] synonym: "cavernous sinus syndrome" RELATED [Wikipedia:Cavernous_sinus] synonym: "cavernous sinuses" RELATED [Wikipedia:Cavernous_sinus] synonym: "cavernus sinus vein" RELATED [Wikipedia:Cavernous_sinus] synonym: "parasellar syndrome" RELATED [Wikipedia:Cavernous_sinus] synonym: "sinus cavernosus" RELATED [Wikipedia:Cavernous_sinus] xref: EMAPA:19059 xref: FMA:50772 xref: GAID:532 xref: MESH:D002426 xref: NCIT:C12690 xref: SCTID:244402005 xref: UMLS:C0007473 {source="ncithesaurus:Cavernous_Sinus"} xref: Wikipedia:Cavernous_sinus is_a: UBERON:0005486 ! venous dural sinus relationship: RO:0002170 UBERON:0007160 ! connected to inferior petrosal sinus property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0003713 name: splenic vein def: "A vein arising from the splenic trabecular vein in the hilum of the spleen that drains into the portal vein." [ncithesaurus:Splenic_Vein] subset: human_reference_atlas synonym: "lienal vein" RELATED [MA:0002164, Wikipedia:Splenic_vein] synonym: "vena lienalis" RELATED OMO:0003011 [Wikipedia:Splenic_vein] synonym: "vena splenica" EXACT OMO:0003011 [FMA:14331, FMA:TA] xref: EMAPA:37226 {source="MA:th"} xref: FMA:14331 xref: GAID:541 xref: galen:SplenicVein xref: MA:0002164 xref: MESH:D013162 xref: NCIT:C33608 xref: SCTID:278029005 xref: UMLS:C0038001 {source="ncithesaurus:Splenic_Vein"} xref: Wikipedia:Splenic_vein is_a: UBERON:0001638 ! vein relationship: RO:0002170 UBERON:0001639 ! connected to hepatic portal vein property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/5/5b/Gray1189.png" xsd:anyURI property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/e/e4/Bilebladder.png" xsd:anyURI property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/blood-vasculature-female/v1.3/assets/3d-vh-f-blood-vasculature.glb" xsd:anyURI property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/blood-vasculature-male/v1.3/assets/3d-vh-m-blood-vasculature.glb" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "splenic vein" xsd:string [Term] id: UBERON:0003714 name: neural tissue def: "Portion of tissue in the nervous system which consists of neurons and glial cells, and may also contain parts of the vasculature." [FMA:9642] synonym: "nerve tissue" EXACT [FMA:9642] synonym: "nervous tissue" EXACT [FMA:9642] synonym: "portion of neural tissue" EXACT [FMA:9642] xref: AAO:0000325 xref: AEO:0000123 xref: EHDAA2:0003123 xref: FMA:9642 xref: GAID:609 xref: MESH:D009417 xref: NCIT:C13052 xref: SCTID:91728009 xref: UMLS:C0027757 {source="ncithesaurus:Nervous_Tissue"} is_a: BFO:0000002 is_a: UBERON:0000479 ! tissue intersection_of: UBERON:0000479 ! tissue intersection_of: BFO:0000051 CL:0000125 ! has part glial cell intersection_of: BFO:0000051 CL:0000540 ! has part neuron disjoint_from: UBERON:0004755 ! skeletal tissue relationship: BFO:0000050 UBERON:0001016 ! part of nervous system relationship: BFO:0000051 CL:0000125 ! has part glial cell relationship: BFO:0000051 CL:0000540 ! has part neuron property_value: skos:prefLabel "neural tissue" xsd:string [Term] id: UBERON:0003715 name: splanchnic nerve def: "The major nerves supplying sympathetic innervation to the abdomen, including the greater, lesser, and lowest (or smallest) splanchnic nerves that are formed by preganglionic fibers from the spinal cord which pass through the paravertebral ganglia and then to the celiac ganglia and plexuses and the lumbar splanchnic nerves carry fibers which pass through the lumbar paravertebral ganglia to the mesenteric and hypogastric ganglia." [MP:0008318] subset: human_reference_atlas subset: pheno_slim synonym: "splanchnic nerves" RELATED [BAMS:spn] synonym: "visceral nerve" RELATED [Wikipedia:Splanchnic_nerves] xref: BAMS:spn xref: EMAPA:37959 {source="MA:th"} xref: FMA:5883 xref: GAID:800 xref: MESH:D013153 xref: SCTID:264198001 xref: Wikipedia:Splanchnic_nerves is_a: UBERON:0034729 ! sympathetic nerve intersection_of: UBERON:0001021 ! nerve intersection_of: RO:0002134 UBERON:0000916 ! innervates abdomen relationship: RO:0002134 UBERON:0000916 ! innervates abdomen relationship: RO:0002433 UBERON:0000013 ! contributes to morphology of sympathetic nervous system property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "splanchnic nerve" xsd:string [Term] id: UBERON:0003716 name: recurrent laryngeal nerve def: "A branch of the vagus nerve that supplies motor function and sensation to the larynx (voice box). It travels within the endoneurium. It is the nerve of the 6th Branchial Arch." [Wikipedia:Recurrent_laryngeal_nerve] subset: human_reference_atlas synonym: "inferior laryngeal nerve" RELATED [GAID:804] synonym: "nervus laryngeus recurrens" EXACT OMO:0003011 [Wikipedia:Recurrent_laryngeal_nerve] synonym: "ramus recurrens" RELATED [AAO:0010754] synonym: "recurrent laryngeal nerve from vagus nerve" EXACT [] synonym: "recurrent nerve" BROAD [Wikipedia:Recurrent_laryngeal_nerve] synonym: "vagus X nerve recurrent laryngeal branch" EXACT [VHOG:0001347] xref: AAO:0010754 xref: FMA:6246 xref: GAID:804 xref: MESH:D012009 xref: SCTID:24227007 xref: VHOG:0001347 xref: Wikipedia:Recurrent_laryngeal_nerve is_a: BFO:0000002 is_a: UBERON:0011779 ! nerve of head region is_a: UBERON:0035642 ! laryngeal nerve relationship: RO:0002202 UBERON:0003117 {source="Wikipedia"} ! develops from pharyngeal arch 6 relationship: RO:0002380 UBERON:0001759 ! branching part of vagus nerve property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "recurrent laryngeal nerve" xsd:string [Term] id: UBERON:0003718 name: muscle spindle def: "The sensory organs in muscle that are involved in the stretch reflex." [MP:0004069] subset: pheno_slim synonym: "muscle stretch receptor" RELATED [GAID:819] synonym: "neuromuscular spindle" EXACT [FMA:83607] synonym: "neuromuscular spindle" RELATED [GAID:819] xref: FMA:83607 xref: GAID:819 xref: MESH:D009470 xref: NCIT:C13824 xref: SCTID:12945004 xref: UMLS:C0027871 {source="ncithesaurus:Muscle_Spindle"} is_a: UBERON:0000061 ! anatomical structure relationship: BFO:0000050 UBERON:0001016 ! part of nervous system [Term] id: UBERON:0003721 name: lingual nerve def: "The lingual nerve is a branch of the mandibular nerve (CN V3), itself a branch of the trigeminal nerve, which supplies sensory innervation to the tongue. It also carries fibers from the facial nerve, which return taste information from the anterior two thirds of the tongue." [Wikipedia:Lingual_nerve] subset: human_reference_atlas synonym: "lingual branch of trigeminal nerve" EXACT [] synonym: "trigeminal nerve lingual branch" EXACT [] synonym: "trigeminal V nerve lingual branch" EXACT [MA:0001102] xref: BAMS:5lg xref: EMAPA:19168 xref: FMA:53218 xref: GAID:835 xref: MA:0001102 xref: MESH:D008036 xref: SCTID:280260006 xref: Wikipedia:Lingual_nerve is_a: UBERON:0011779 ! nerve of head region intersection_of: UBERON:0001021 ! nerve intersection_of: RO:0002134 UBERON:0001723 ! innervates tongue relationship: RO:0002134 UBERON:0001723 ! innervates tongue relationship: RO:0002380 UBERON:0000375 ! branching part of mandibular nerve property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "lingual nerve" xsd:string [Term] id: UBERON:0003723 name: vestibular nerve def: "The vestibular nerve is one of the two branches of the Vestibulocochlear nerve (the cochlear nerve being the other). It goes to the semicircular canals via the vestibular ganglion. It receives positional information. Axons of the vestibular nerve synapse in the vestibular nucleus on the lateral floor and wall of the fourth ventricle in the pons and medulla. It arises from bipolar cells in the vestibular ganglion, ganglion of Scarpa, which is situated in the upper part of the outer end of the internal auditory meatus. [WP,unvetted]." [Wikipedia:Vestibular_nerve] subset: pheno_slim synonym: "nervus vestibularis" RELATED OMO:0003011 [Wikipedia:Vestibular_nerve] synonym: "scarpa ganglion" RELATED [GAID:840] synonym: "scarpa's ganglion" RELATED [GAID:840] synonym: "scarpas ganglion" RELATED [GAID:840] synonym: "vestibular root of acoustic nerve" EXACT [FMA:53401] synonym: "vestibular root of eighth cranial nerve" EXACT [FMA:53401] synonym: "vestibulocochlear nerve vestibular root" RELATED [BAMS:vVIIIn] synonym: "vestibulocochlear VIII nerve vestibular component" EXACT [MA:0001111] xref: BAMS:vVIIIn xref: EHDAA2:0002200 xref: EHDAA:3749 xref: EMAPA:17803 xref: FMA:53401 xref: GAID:840 xref: MA:0001111 xref: MBA:413 xref: MESH:D014725 xref: NCIT:C12820 xref: neuronames:1389 xref: SCTID:362464003 xref: UMLS:C0042598 {source="ncithesaurus:Vestibular_Nerve"} xref: VHOG:0001181 xref: Wikipedia:Vestibular_nerve is_a: UBERON:0011779 ! nerve of head region intersection_of: UBERON:0001021 ! nerve intersection_of: extends_fibers_into UBERON:0007228 ! vestibular nucleus intersection_of: RO:0002134 UBERON:0001840 ! innervates semicircular canal intersection_of: RO:0002134 UBERON:0006585 ! innervates vestibular organ intersection_of: RO:0002380 UBERON:0001648 ! branching part of vestibulocochlear nerve relationship: BFO:0000050 UBERON:0004681 ! part of vestibular system relationship: extends_fibers_into UBERON:0007228 ! vestibular nucleus relationship: RO:0002134 UBERON:0001840 ! innervates semicircular canal relationship: RO:0002134 UBERON:0006585 ! innervates vestibular organ relationship: RO:0002380 UBERON:0001648 ! branching part of vestibulocochlear nerve property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/6/65/Vestibular_system%27s_semicircular_canal-_a_cross-section.jpg" xsd:anyURI property_value: skos:prefLabel "vestibular nerve" xsd:string [Term] id: UBERON:0003726 name: thoracic nerve def: "The twelve spinal nerves on each side of the thorax. They include eleven INTERCOSTAL NERVES and one subcostal nerve. Both sensory and motor, they supply the muscles and skin of the thoracic and abdominal walls." [MESH:A08.800.800.720.800] subset: human_reference_atlas synonym: "nervi thoracici" RELATED OMO:0003011 [Wikipedia:Thoracic_nerves] synonym: "nervus thoracis" EXACT OMO:0003011 [FMA:5860, FMA:TA] synonym: "pectoral nerve" RELATED [GAID:857] synonym: "thoracic spinal nerve" EXACT [FMA:5860] xref: FMA:5860 xref: GAID:857 xref: MESH:D013900 xref: neuronames:1725 xref: SCTID:360498003 xref: Wikipedia:Thoracic_nerves is_a: UBERON:0001780 ! spinal nerve intersection_of: UBERON:0001780 ! spinal nerve intersection_of: extends_fibers_into UBERON:0003038 ! thoracic spinal cord relationship: extends_fibers_into UBERON:0003038 ! thoracic spinal cord property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "thoracic nerve" xsd:string [Term] id: UBERON:0003727 name: intercostal nerve def: "The intercostal nerves are the anterior divisions (rami anteriores; ventral divisions) of the thoracic spinal nerves from T1 to T11. Each nerve is connected with the adjoining ganglion of the sympathetic trunk by a gray and a white ramus communicans. The intercostal nerves are distributed chiefly to the thoracic pleura and abdominal peritoneum and differ from the anterior divisions of the other spinal nerves in that each pursues an independent course without plexus formation. The first two nerves supply fibers to the upper limb in addition to their thoracic branches; the next four are limited in their distribution to the parietes of the thorax; the lower five supply the parietes of the thorax and abdomen. The 7th intercostal nerve terminates at the xyphoid process, at the lower end of the sternum. The 10th intercostal nerve terminates at the umbilicus. The twelfth thoracic is distributed to the abdominal wall and groin. [WP,unvetted]." [Wikipedia:Intercostal_nerves] synonym: "anterior ramus of thoracic nerve" EXACT [FMA:6028] synonym: "anterior ramus of thoracic spinal nerve" EXACT [FMA:6028] synonym: "nervi intercostales" RELATED OMO:0003011 [Wikipedia:Intercostal_nerves] synonym: "ramus anterior, nervus thoracicus" EXACT [FMA:6028] synonym: "thoracic anterior ramus" EXACT [FMA:6028] synonym: "ventral ramus of thoracic spinal nerve" EXACT [FMA:6028] xref: EMAPA:18227 xref: FMA:6028 xref: GAID:858 xref: MESH:D007367 xref: NCIT:C32825 xref: SCTID:279568001 xref: UMLS:C1285089 {source="ncithesaurus:Intercostal_Nerve"} xref: Wikipedia:Intercostal_nerves is_a: UBERON:0001780 ! spinal nerve property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/b/b1/Gray819.png" xsd:anyURI property_value: skos:prefLabel "intercostal nerve" xsd:string [Term] id: UBERON:0003728 name: mediastinum def: "The central part of the thoracic cavity enclosed by the left and right pleurae." [UBERON:cjm, Wikipedia:Mediastinum] subset: efo_slim subset: pheno_slim synonym: "mediastinal part of chest" EXACT [FMA:9826] xref: CALOHA:TS-2338 xref: EFO:0003057 xref: EMAPA:36001 xref: FMA:9826 xref: GAID:94 xref: MA:0003075 xref: MESH:D008482 xref: NCIT:C12748 xref: SCTID:181217005 xref: UMLS:C0025066 {source="ncithesaurus:Mediastinum"} xref: Wikipedia:Mediastinum is_a: UBERON:0002553 ! anatomical cavity relationship: BFO:0000050 UBERON:0002224 ! part of thoracic cavity relationship: RO:0002219 UBERON:0035431 {source="FMA"} ! surrounded by mediastinal pleura property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/a/ab/Mediastinum.png" xsd:anyURI [Term] id: UBERON:0003729 name: mouth mucosa def: "A mucous membrane that lines the mouth." [http://orcid.org/0000-0002-6601-2165] subset: human_reference_atlas subset: pheno_slim synonym: "buccal mucosa" RELATED [GAID:951] synonym: "mouth mucosa" EXACT [FMA:59660] synonym: "mouth mucous membrane" EXACT [OBOL:accepted] synonym: "mouth organ mucosa" EXACT [OBOL:accepted] synonym: "mucosa of mouth" EXACT [OBOL:accepted] synonym: "mucosal lining of mouth" RELATED [MA:0002794] synonym: "mucous membrane of mouth" EXACT [FMA:59660] synonym: "oral mucosa" RELATED [GAID:951] synonym: "oral mucous membrane" EXACT [] synonym: "oral part of viscerocranial mucosa" EXACT [FMA:59660] synonym: "tunica mucosa oris" EXACT OMO:0003011 [FMA:59660, FMA:TA] synonym: "tunica mucosa oris" RELATED OMO:0003011 [Wikipedia:Oral_mucosa] xref: BTO:0002860 xref: CALOHA:TS-0716 xref: EMAPA:26937 xref: FMA:59660 xref: GAID:951 xref: MA:0002794 xref: MESH:D009061 xref: NCIT:C77637 xref: UMLS:C0026639 {source="ncithesaurus:Oral_Mucosa"} xref: Wikipedia:Oral_mucosa is_a: UBERON:0000344 ! mucosa intersection_of: UBERON:0000344 ! mucosa intersection_of: BFO:0000050 UBERON:0000165 ! part of mouth relationship: RO:0002007 UBERON:0000165 ! bounding layer of mouth relationship: RO:0002150 UBERON:0000355 ! continuous with pharyngeal mucosa relationship: RO:0002150 UBERON:0001458 ! continuous with skin of lip relationship: RO:0002433 UBERON:0001007 ! contributes to morphology of digestive system property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "mouth mucosa" xsd:string [Term] id: UBERON:0003820 name: prostate bud def: "A region of the fetal urogenital sinus epithelium destined to become the prostate[GO]." [GO:0060513] synonym: "prostate ductal progenitor" EXACT [PMID:18977204] synonym: "prostate gland bud" RELATED [EMAPA:36141] synonym: "prostate primordium" RELATED [] synonym: "prostatic bud" EXACT [] xref: EMAPA:36141 is_a: UBERON:0004902 ! urogenital sinus epithelium is_a: UBERON:0005153 ! epithelial bud intersection_of: UBERON:0005153 ! epithelial bud intersection_of: RO:0002387 UBERON:0002367 ! has potential to develop into prostate gland relationship: BFO:0000050 UBERON:0004902 ! part of urogenital sinus epithelium relationship: RO:0002202 UBERON:0009847 {source="PMID:18977204"} ! develops from prostate field relationship: RO:0002387 UBERON:0002367 ! has potential to develop into prostate gland [Term] id: UBERON:0003821 name: metapodium bone def: "A bone of the metapodial skeleton." [https://orcid.org/0000-0002-6601-2165] synonym: "metacarpal or metatarsal bone" EXACT [] synonym: "metacarpal/metatarsal" EXACT [] synonym: "metacarpal/metatarsal bone" EXACT [MA:0000301] synonym: "metapodi bone" EXACT [https://orcid.org/0000-0002-6601-2165] synonym: "metapodial bone" EXACT [https://orcid.org/0000-0002-6601-2165] synonym: "metapodium bone" EXACT [http://en.wiktionary.org/wiki/metapodial, https://orcid.org/0000-0002-6601-2165] xref: EMAPA:37284 {source="MA:th"} xref: MA:0000301 is_a: UBERON:0003606 ! limb long bone is_a: UBERON:0012357 ! digitopodium bone intersection_of: UBERON:0001474 ! bone element intersection_of: BFO:0000050 UBERON:0009877 ! part of metapodium region relationship: BFO:0000050 UBERON:0010546 ! part of metapodial skeleton [Term] id: UBERON:0003822 name: forelimb stylopod def: "The part of the forelimb between pectoral region and the elbow, corresponding to the humerus." [http://orcid.org/0000-0002-6601-2165] subset: pheno_slim synonym: "arm" RELATED INCONSISTENT [FMA:24890] synonym: "brachial region" EXACT [] synonym: "brachium" EXACT [VSAO:0005057] synonym: "fore propodium" EXACT [AAO:0000199] synonym: "forelimb propodium" EXACT [] synonym: "forelimb stylopodial element" EXACT [MA:th] synonym: "forelimb stylopodium" EXACT [OBOL:automatic] synonym: "proximal segment of free upper limb" EXACT [] synonym: "regio brachialis" EXACT OMO:0003011 [FMA:24890, FMA:TA] synonym: "stylopod of arm" EXACT [] synonym: "stylopod of forelimb" EXACT [] synonym: "upper arm" EXACT HUMAN_PREFERRED [MA:0000035] synonym: "wing stylopod" NARROW SENSU [NCBITaxon:8782, OBOL:automatic] xref: AAO:0000199 xref: EHDAA2:0002112 xref: EHDAA:4186 xref: EHDAA:6234 xref: EMAPA:17424 xref: FMA:24890 xref: galen:Arm xref: MA:0000035 xref: MESH:D001132 xref: NCIT:C32141 xref: SCTID:302538001 xref: UMLS:C0446516 {source="ncithesaurus:Arm"} xref: VHOG:0000343 xref: VSAO:0005057 is_a: UBERON:0002472 ! stylopod is_a: UBERON:0008785 ! upper limb segment intersection_of: UBERON:0002472 ! stylopod intersection_of: BFO:0000050 UBERON:0002102 ! part of forelimb relationship: BFO:0000050 UBERON:0001460 {source="MA"} ! part of arm relationship: RO:0002433 UBERON:0002102 ! contributes to morphology of forelimb relationship: RO:0002551 UBERON:0015053 ! has skeleton humerus endochondral element [Term] id: UBERON:0003823 name: hindlimb zeugopod def: "The middle limb segment of the pelvic free limb, between the autopod and stylopod segments. Includes as parts the hindlimb zeugopodial skeleton, which includes as parts the tibia and fibula, or their cartilage precursors, or evolutionary variants." [PHENOSCAPE:curators] subset: efo_slim subset: pheno_slim synonym: "crus" EXACT [VSAO:0005060] synonym: "crus of hindlimb" EXACT [] synonym: "hind epipodium" RELATED INCONSISTENT [] synonym: "hind limb middle limb segment" EXACT [OBOL:automatic] synonym: "hind limb zeudopodium" EXACT [VHOG:0000348] synonym: "hind limb zeugopod" EXACT [OBOL:automatic] synonym: "hindlimb epipodium" EXACT [] synonym: "hindlimb middle limb segment" EXACT [OBOL:automatic] synonym: "hindlimb zeudopodium" EXACT [VHOG:0000348] synonym: "hindlimb zeugopod" EXACT [OBOL:automatic] synonym: "hindlimb zeugopodium" EXACT [OBOL:automatic] synonym: "intermediate segment of free lower limb" EXACT [FMA:24979] synonym: "leg" RELATED INCONSISTENT [FMA:24979, MESH:A01.378.610.500] synonym: "lower extremity middle limb segment" EXACT [OBOL:automatic] synonym: "lower extremity zeugopod" EXACT [OBOL:automatic] synonym: "lower leg" EXACT HUMAN_PREFERRED [MA:0000051] synonym: "middle limb segment of hind limb" EXACT [OBOL:automatic] synonym: "middle limb segment of hindlimb" EXACT [https://orcid.org/0000-0002-6601-2165] synonym: "shank" EXACT [VSAO:0005060] synonym: "zeugopod of hind limb" EXACT [OBOL:automatic] synonym: "zeugopod of hindlimb" EXACT [OBOL:automatic] xref: EFO:0003051 xref: EHDAA2:0001030 xref: EHDAA:5165 xref: EHDAA:6190 xref: EMAPA:17496 xref: FMA:24979 xref: galen:Leg xref: MA:0000051 xref: MESH:D007866 xref: NCIT:C32974 xref: SCTID:244015008 xref: UMLS:C1140621 {source="ncithesaurus:Leg"} xref: VHOG:0000348 xref: VSAO:0005060 xref: Wikipedia:Forearm is_a: UBERON:0002471 ! zeugopod is_a: UBERON:0008784 ! lower limb segment intersection_of: UBERON:0002471 ! zeugopod intersection_of: BFO:0000050 UBERON:0002103 ! part of hindlimb relationship: BFO:0000050 UBERON:0000978 {source="MA"} ! part of leg relationship: RO:0002433 UBERON:0002103 ! contributes to morphology of hindlimb relationship: RO:0002551 UBERON:0010720 ! has skeleton hindlimb zeugopod skeleton [Term] id: UBERON:0003824 name: nerve of thoracic segment def: "A nerve that is part of a thorax [Automatically generated definition]." [OBOL:automatic] synonym: "nerve of thorax" EXACT [OBOL:automatic] synonym: "thoracic segment nerve" EXACT [MA:0000562] synonym: "thorax nerve" EXACT [OBOL:automatic] synonym: "upper body nerve" RELATED [MA:0000562] xref: EMAPA:37265 {source="MA:th"} xref: MA:0000562 xref: MESH:D013900 xref: SCTID:359876006 is_a: UBERON:0003439 ! nerve of trunk region intersection_of: UBERON:0001021 ! nerve intersection_of: BFO:0000050 UBERON:0000915 ! part of thoracic segment of trunk relationship: BFO:0000050 UBERON:0000915 ! part of thoracic segment of trunk property_value: skos:prefLabel "nerve of thoracic segment" xsd:string [Term] id: UBERON:0003825 name: nerve of abdominal segment def: "A nerve that is part of an abdominal segment of trunk [Automatically generated definition]." [OBOL:automatic] synonym: "abdominal segment nerve" EXACT [MA:0000528] xref: EMAPA:37061 {source="MA:th"} xref: MA:0000528 is_a: UBERON:0003439 ! nerve of trunk region intersection_of: UBERON:0001021 ! nerve intersection_of: BFO:0000050 UBERON:0002417 ! part of abdominal segment of trunk relationship: BFO:0000050 UBERON:0002417 ! part of abdominal segment of trunk property_value: skos:prefLabel "nerve of abdominal segment" xsd:string [Term] id: UBERON:0003826 name: upper leg bone def: "A bone that is part of a hindlimb stylopod [Automatically generated definition]." [https://sourceforge.net/tracker/index.php?func=detail&aid=3586533&group_id=76834&atid=1205376, OBOL:automatic] comment: May be merged into femur. See https://sourceforge.net/tracker/index.php?func=detail&aid=3586533&group_id=76834&atid=1205376 synonym: "femur" RELATED [https://sourceforge.net/tracker/index.php?func=detail&aid=3586533&group_id=76834&atid=1205376] xref: EMAPA:35893 xref: MA:0000682 is_a: UBERON:0005893 ! leg bone intersection_of: UBERON:0001474 ! bone element intersection_of: BFO:0000050 UBERON:0000376 ! part of hindlimb stylopod relationship: BFO:0000050 UBERON:0000376 ! part of hindlimb stylopod [Term] id: UBERON:0003827 name: thoracic segment bone def: "A bone that is part of a thorax [Automatically generated definition]." [OBOL:automatic] synonym: "bone of thorax" EXACT [OBOL:automatic] synonym: "bone organ of thorax" EXACT [OBOL:automatic] synonym: "thorax bone" EXACT [OBOL:automatic] synonym: "thorax bone organ" EXACT [OBOL:automatic] synonym: "upper body bone" RELATED [MA:0000559] xref: EMAPA:37247 {source="MA:th"} xref: MA:0000559 xref: SCTID:426649006 is_a: UBERON:0003463 ! trunk bone is_a: UBERON:0005181 ! thoracic segment organ intersection_of: UBERON:0001474 ! bone element intersection_of: BFO:0000050 UBERON:0000915 ! part of thoracic segment of trunk property_value: skos:prefLabel "thoracic segment bone" xsd:string [Term] id: UBERON:0003828 name: abdominal segment bone def: "A bone that is part of an abdominal segment of trunk [Automatically generated definition]." [OBOL:automatic] synonym: "abdominal segment of trunk bone" EXACT [OBOL:automatic] synonym: "abdominal segment of trunk bone organ" EXACT [OBOL:automatic] synonym: "bone of abdominal segment of trunk" EXACT [OBOL:automatic] synonym: "bone organ of abdominal segment of trunk" EXACT [OBOL:automatic] xref: EMAPA:37058 {source="MA:th"} xref: MA:0000525 is_a: UBERON:0003463 ! trunk bone is_a: UBERON:0005173 ! abdominal segment element intersection_of: UBERON:0001474 ! bone element intersection_of: BFO:0000050 UBERON:0002417 ! part of abdominal segment of trunk property_value: skos:prefLabel "abdominal segment bone" xsd:string [Term] id: UBERON:0003829 name: urethra muscle tissue def: "Any muscle tissue that is part of the urethra." [UBERON:cjm] synonym: "urethral muscle layer" RELATED [MA:0002649] xref: EMAPA:37787 {source="MA:th"} xref: MA:0002649 is_a: UBERON:0005090 ! muscle structure intersection_of: UBERON:0005090 ! muscle structure intersection_of: BFO:0000050 UBERON:0000057 ! part of urethra relationship: BFO:0000050 UBERON:0000057 ! part of urethra [Term] id: UBERON:0003830 name: thoracic segment muscle def: "Any muscle organ that is part of a thorax [Automatically generated definition]." [OBOL:automatic] synonym: "muscle organ of thorax" EXACT [OBOL:automatic] synonym: "thorax muscle organ" EXACT [OBOL:automatic] synonym: "upper body muscle" RELATED [MA:0000561] xref: MA:0000561 is_a: UBERON:0001774 ! skeletal muscle of trunk is_a: UBERON:0005181 ! thoracic segment organ intersection_of: UBERON:0014892 ! skeletal muscle organ, vertebrate intersection_of: BFO:0000050 UBERON:0000915 ! part of thoracic segment of trunk relationship: BFO:0000050 UBERON:0004464 {source="prolog"} ! part of musculature of thorax property_value: skos:prefLabel "thoracic segment muscle" xsd:string [Term] id: UBERON:0003831 name: respiratory system muscle def: "Any muscle organ that is part of a respiratory system [Automatically generated definition]." [OBOL:automatic] synonym: "apparatus respiratorius muscle organ" EXACT [OBOL:automatic] synonym: "muscle organ of apparatus respiratorius" EXACT [OBOL:automatic] synonym: "muscle organ of respiratory system" EXACT [OBOL:automatic] synonym: "respiratory system muscle organ" EXACT [OBOL:automatic] xref: EMAPA:35733 xref: MA:0001828 is_a: UBERON:0001630 ! muscle organ intersection_of: UBERON:0001630 ! muscle organ intersection_of: BFO:0000050 UBERON:0001004 ! part of respiratory system relationship: BFO:0000050 UBERON:0001004 ! part of respiratory system property_value: skos:prefLabel "respiratory system muscle" xsd:string [Term] id: UBERON:0003832 name: esophagus muscle def: "Any muscle organ that is part of a esophagus [Automatically generated definition]." [OBOL:automatic] synonym: "esophageal muscle" EXACT [] synonym: "esophagus muscle organ" EXACT [OBOL:automatic] synonym: "gullet muscle organ" EXACT [OBOL:automatic] synonym: "muscle organ of esophagus" EXACT [OBOL:automatic] synonym: "muscle organ of gullet" EXACT [OBOL:automatic] synonym: "muscle organ of oesophagus" EXACT [OBOL:automatic] synonym: "oesophagus muscle organ" EXACT [OBOL:automatic] xref: EMAPA:26983 xref: MA:0002682 xref: SCTID:360961009 is_a: UBERON:0001630 ! muscle organ is_a: UBERON:0013765 ! digestive system element intersection_of: UBERON:0001630 ! muscle organ intersection_of: BFO:0000050 UBERON:0001043 ! part of esophagus relationship: BFO:0000050 UBERON:0001096 {source="MA"} ! part of wall of esophagus property_value: IAO:0000116 "merge muscle and muscle layer?" xsd:string property_value: skos:prefLabel "esophagus muscle" xsd:string [Term] id: UBERON:0003833 name: abdominal segment muscle def: "A muscle organ that is part of an abdominal segment of trunk [Automatically generated definition]." [OBOL:automatic] synonym: "abdominal segment of trunk muscle organ" EXACT [OBOL:automatic] synonym: "muscle organ of abdominal segment of trunk" EXACT [OBOL:automatic] xref: EMAPA:37060 {source="MA:th"} xref: MA:0000527 is_a: UBERON:0001774 ! skeletal muscle of trunk is_a: UBERON:0005173 ! abdominal segment element intersection_of: UBERON:0014892 ! skeletal muscle organ, vertebrate intersection_of: BFO:0000050 UBERON:0002417 ! part of abdominal segment of trunk property_value: skos:prefLabel "abdominal segment muscle" xsd:string [Term] id: UBERON:0003834 name: thoracic segment blood vessel def: "A blood vessel that is part of a thorax [Automatically generated definition]." [OBOL:automatic] synonym: "blood vessel of thorax" EXACT [OBOL:automatic] synonym: "thorax blood vessel" EXACT [OBOL:automatic] synonym: "upper body blood vessel" RELATED [MA:0000558] xref: EMAPA:37238 {source="MA:th"} xref: MA:0000558 is_a: UBERON:0003513 ! trunk blood vessel intersection_of: UBERON:0001981 ! blood vessel intersection_of: BFO:0000050 UBERON:0000915 ! part of thoracic segment of trunk relationship: BFO:0000050 UBERON:0000915 ! part of thoracic segment of trunk property_value: skos:prefLabel "thoracic segment blood vessel" xsd:string [Term] id: UBERON:0003835 name: abdominal segment blood vessel def: "A blood vessel that is part of an abdominal segment of trunk [Automatically generated definition]." [OBOL:automatic] synonym: "abdominal segment of trunk blood vessel" EXACT [OBOL:automatic] synonym: "blood vessel of abdominal segment of trunk" EXACT [OBOL:automatic] xref: EMAPA:37057 {source="MA:th"} xref: MA:0000524 is_a: UBERON:0003513 ! trunk blood vessel intersection_of: UBERON:0001981 ! blood vessel intersection_of: BFO:0000050 UBERON:0002417 ! part of abdominal segment of trunk relationship: BFO:0000050 UBERON:0002417 ! part of abdominal segment of trunk property_value: skos:prefLabel "abdominal segment blood vessel" xsd:string [Term] id: UBERON:0003836 name: abdominal segment skin def: "A skin of body that is part of an abdominal segment of trunk [Automatically generated definition]." [OBOL:automatic] synonym: "abdominal segment of trunk skin" EXACT [OBOL:automatic] synonym: "skin of abdominal segment of trunk" EXACT [OBOL:automatic] xref: EMAPA:37063 {source="MA:th"} xref: FMA:264898 xref: MA:0000530 is_a: UBERON:0001085 ! skin of trunk intersection_of: UBERON:0000014 ! zone of skin intersection_of: BFO:0000050 UBERON:0002417 ! part of abdominal segment of trunk relationship: BFO:0000050 UBERON:0002417 ! part of abdominal segment of trunk property_value: skos:prefLabel "abdominal segment skin" xsd:string [Term] id: UBERON:0003837 name: thoracic segment connective tissue def: "A portion of connective tissue that is part of a thorax [Automatically generated definition]." [OBOL:automatic] synonym: "connective tissue of thorax" EXACT [OBOL:automatic] synonym: "portion of connective tissue of thorax" EXACT [OBOL:automatic] synonym: "textus connectivus of thorax" EXACT [OBOL:automatic] synonym: "thorax connective tissue" EXACT [OBOL:automatic] synonym: "thorax portion of connective tissue" EXACT [OBOL:automatic] synonym: "thorax textus connectivus" EXACT [OBOL:automatic] synonym: "upper body connective tissue" RELATED [MA:0000560] xref: EMAPA:37253 {source="MA:th"} xref: MA:0000560 is_a: UBERON:0003586 ! trunk connective tissue intersection_of: UBERON:0002384 ! connective tissue intersection_of: BFO:0000050 UBERON:0000915 ! part of thoracic segment of trunk relationship: BFO:0000050 UBERON:0000915 ! part of thoracic segment of trunk property_value: skos:prefLabel "thoracic segment connective tissue" xsd:string [Term] id: UBERON:0003838 name: abdominal segment connective tissue def: "A portion of connective tissue that is part of an abdominal segment of trunk [Automatically generated definition]." [OBOL:automatic] synonym: "abdominal segment of trunk connective tissue" EXACT [OBOL:automatic] synonym: "abdominal segment of trunk portion of connective tissue" EXACT [OBOL:automatic] synonym: "abdominal segment of trunk textus connectivus" EXACT [OBOL:automatic] synonym: "connective tissue of abdominal segment of trunk" EXACT [OBOL:automatic] synonym: "portion of connective tissue of abdominal segment of trunk" EXACT [OBOL:automatic] synonym: "textus connectivus of abdominal segment of trunk" EXACT [OBOL:automatic] xref: EMAPA:37059 {source="MA:th"} xref: MA:0000526 is_a: UBERON:0003586 ! trunk connective tissue intersection_of: UBERON:0002384 ! connective tissue intersection_of: BFO:0000050 UBERON:0002417 ! part of abdominal segment of trunk relationship: BFO:0000050 UBERON:0002417 ! part of abdominal segment of trunk property_value: skos:prefLabel "abdominal segment connective tissue" xsd:string [Term] id: UBERON:0003839 name: forelimb joint def: "A limb joint that is part of a forelimb [Automatically generated definition]." [OBOL:automatic] subset: pheno_slim synonym: "anteriormost limb joint of limb" EXACT [OBOL:automatic] synonym: "anteriormost limb limb joint" EXACT [OBOL:automatic] synonym: "fore limb joint of limb" EXACT [OBOL:automatic] synonym: "fore limb limb joint" EXACT [OBOL:automatic] synonym: "forelimb joint of limb" EXACT [OBOL:automatic] synonym: "forelimb limb joint" EXACT [OBOL:automatic] synonym: "joint of free upper limb" EXACT [http://orcid.org/0000-0002-6601-2165] synonym: "joint of limb of anteriormost limb" EXACT [OBOL:automatic] synonym: "joint of limb of fore limb" EXACT [OBOL:automatic] synonym: "joint of limb of forelimb" EXACT [OBOL:automatic] synonym: "joint of limb of superior member" EXACT [OBOL:automatic] synonym: "joint of limb of upper extremity" EXACT [OBOL:automatic] synonym: "limb joint of anteriormost limb" EXACT [OBOL:automatic] synonym: "limb joint of fore limb" EXACT [OBOL:automatic] synonym: "limb joint of forelimb" EXACT [OBOL:automatic] synonym: "limb joint of superior member" EXACT [OBOL:automatic] synonym: "limb joint of upper extremity" EXACT [OBOL:automatic] synonym: "superior member joint of limb" EXACT [OBOL:automatic] synonym: "superior member limb joint" EXACT [OBOL:automatic] synonym: "upper extremity joint of limb" EXACT [OBOL:automatic] synonym: "upper extremity limb joint" EXACT [OBOL:automatic] synonym: "wing joint" NARROW SENSU [NCBITaxon:8782, OBOL:automatic] xref: EMAPA:19204 xref: MA:0000614 is_a: UBERON:0003657 ! limb joint intersection_of: UBERON:0000982 ! skeletal joint intersection_of: BFO:0000050 UBERON:0002102 ! part of forelimb relationship: BFO:0000050 UBERON:0002102 ! part of forelimb [Term] id: UBERON:0003840 name: hindlimb joint def: "A limb joint that is part of a hindlimb [Automatically generated definition]." [OBOL:automatic] subset: pheno_slim synonym: "hind limb joint of limb" EXACT [OBOL:automatic] synonym: "hind limb limb joint" EXACT [OBOL:automatic] synonym: "hindlimb joint of limb" EXACT [OBOL:automatic] synonym: "hindlimb limb joint" EXACT [OBOL:automatic] synonym: "inferior member joint of limb" EXACT [OBOL:automatic] synonym: "inferior member limb joint" EXACT [OBOL:automatic] synonym: "joint of free lower limb" EXACT [http://orcid.org/0000-0002-6601-2165] synonym: "joint of limb of hind limb" EXACT [OBOL:automatic] synonym: "joint of limb of hindlimb" EXACT [OBOL:automatic] synonym: "joint of limb of inferior member" EXACT [OBOL:automatic] synonym: "joint of limb of lower extremity" EXACT [OBOL:automatic] synonym: "joint of lower limb" EXACT [https://orcid.org/0000-0002-6601-2165] synonym: "limb joint of hind limb" EXACT [OBOL:automatic] synonym: "limb joint of hindlimb" EXACT [OBOL:automatic] synonym: "limb joint of inferior member" EXACT [OBOL:automatic] synonym: "limb joint of lower extremity" EXACT [OBOL:automatic] synonym: "lower extremity joint of limb" EXACT [OBOL:automatic] synonym: "lower extremity limb joint" EXACT [OBOL:automatic] xref: EMAPA:32635 xref: MA:0000662 xref: SCTID:304573000 is_a: UBERON:0003657 ! limb joint intersection_of: UBERON:0000982 ! skeletal joint intersection_of: BFO:0000050 UBERON:0002103 ! part of hindlimb relationship: BFO:0000050 UBERON:0002103 ! part of hindlimb [Term] id: UBERON:0003841 name: autopod joint def: "A limb joint that is part of an autopod [Automatically generated definition]." [OBOL:automatic] synonym: "autopod joint of limb" EXACT [OBOL:automatic] synonym: "autopod limb joint" EXACT [OBOL:automatic] synonym: "distal free limb segment joint of limb" EXACT [OBOL:automatic] synonym: "distal free limb segment limb joint" EXACT [OBOL:automatic] synonym: "joint of limb of autopod" EXACT [OBOL:automatic] synonym: "joint of limb of distal free limb segment" EXACT [OBOL:automatic] synonym: "limb joint of autopod" EXACT [OBOL:automatic] synonym: "limb joint of distal free limb segment" EXACT [OBOL:automatic] synonym: "paw joint" RELATED [MA:0002715] xref: EMAPA:35160 xref: MA:0002715 is_a: UBERON:0003657 ! limb joint intersection_of: UBERON:0000982 ! skeletal joint intersection_of: BFO:0000050 UBERON:0002470 ! part of autopod region relationship: BFO:0000050 UBERON:0002470 ! part of autopod region [Term] id: UBERON:0003842 name: neural tube lumen def: "An anatomical space that surrounded_by a neural tube." [OBOL:automatic] synonym: "cavity of neural tube" EXACT [https://orcid.org/0000-0002-6601-2165] synonym: "central lumen" RELATED [] synonym: "lumen of neural tube" EXACT [https://orcid.org/0000-0002-6601-2165] synonym: "neural lumen" RELATED [EHDAA:2889] synonym: "neural tube neural lumen" EXACT [EHDAA2:0001269] synonym: "neurocoel" RELATED [VHOG:0001119] synonym: "prosencoel" NARROW [] xref: AAO:0011073 xref: EHDAA2:0001269 xref: EHDAA:2889 xref: EHDAA:914 xref: EMAPA:16167 xref: VHOG:0001119 xref: XAO:0000252 is_a: UBERON:0000464 ! anatomical space intersection_of: UBERON:0000464 ! anatomical space intersection_of: RO:0002572 UBERON:0001049 ! luminal space of neural tube relationship: RO:0002572 UBERON:0001049 ! luminal space of neural tube property_value: skos:prefLabel "neural tube lumen" xsd:string [Term] id: UBERON:0003843 name: dental epithelium def: "Epithelium that is part of a developing tooth or dental organ." [https://github.com/cerivs/zebrafish-anatomical-ontology/issues/107, ZFA:0005134] subset: vertebrate_core synonym: "dental epithelia" EXACT OMO:0003004 [ZFA:0005134] synonym: "dental epithelium" EXACT [ZFA:0005134] synonym: "odontogenic epithelium" EXACT [] synonym: "reduced enamel epithelium" RELATED [BTO:0001723] synonym: "tooth epithelium" EXACT [] xref: AAO:0011027 xref: BTO:0001723 xref: EMAPA:32903 xref: MA:0003151 xref: NCIT:C54296 xref: TAO:0005134 xref: UMLS:C1709309 {source="ncithesaurus:Odontogenic_Epithelial_Remnants"} xref: VHOG:0001443 xref: XAO:0003203 xref: ZFA:0005134 is_a: BFO:0000002 is_a: UBERON:0000483 ! epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: BFO:0000050 UBERON:0005176 ! part of tooth enamel organ relationship: BFO:0000050 UBERON:0005176 ! part of tooth enamel organ relationship: RO:0002202 UBERON:0004362 ! develops from pharyngeal arch 1 property_value: IAO:0000116 "see comments for dental organ." xsd:string property_value: IAO:0000116 "todo - full developmental relationships" xsd:string [Term] id: UBERON:0003846 name: thymus epithelium def: "An epithelium that is part of a thymus, forming a supporting framework[MP,modified]." [MP:0009544] subset: human_reference_atlas subset: pheno_slim synonym: "epithelial tissue of thymus" EXACT [OBOL:automatic] synonym: "epithelial tissue of thymus gland" EXACT [OBOL:automatic] synonym: "epithelium of thymus" EXACT [OBOL:automatic] synonym: "epithelium of thymus gland" EXACT [OBOL:automatic] synonym: "thymic epithelial tissue" EXACT [] synonym: "thymic epithelium" EXACT [BTO:0001836] synonym: "thymus epithelial tissue" EXACT [OBOL:automatic] synonym: "thymus gland epithelial tissue" EXACT [OBOL:automatic] synonym: "thymus gland epithelium" EXACT [OBOL:automatic] xref: BTO:0001836 xref: CALOHA:TS-1040 xref: EHDAA2:0002019 xref: EMAPA:35864 xref: MA:0000768 xref: NCIT:C45713 xref: UMLS:C1711423 {source="ncithesaurus:Thymic_Epithelial_Tissue"} xref: VHOG:0001426 xref: ZFA:0005779 is_a: BFO:0000002 is_a: UBERON:0000483 ! epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: BFO:0000050 UBERON:0002370 ! part of thymus relationship: BFO:0000050 UBERON:0002370 ! part of thymus relationship: BFO:0000051 CL:0002293 ! has part epithelial cell of thymus relationship: BFO:0000051 PR:000007636 {source="PMID:21293377"} ! has part forkhead box protein N1 relationship: RO:0002433 UBERON:0002370 ! contributes to morphology of thymus property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0003847 name: thyroid artery def: "An artery that supplies a thyroid gland." [OBOL:automatic] xref: AAO:0010490 xref: EHDAA2:0002029 xref: EHDAA:7372 xref: EMAPA:18622 xref: MA:0002066 xref: NCIT:C53020 xref: UMLS:C1711424 {source="ncithesaurus:Thyroid_Artery"} xref: VHOG:0001366 is_a: UBERON:0001637 ! artery intersection_of: UBERON:0001637 ! artery intersection_of: RO:0020101 UBERON:0002046 ! vessel supplies blood to thyroid gland relationship: RO:0020101 UBERON:0002046 ! vessel supplies blood to thyroid gland [Term] id: UBERON:0003848 name: gonadal vein def: "In medicine, gonadal vein refers to the blood vessel that carrying blood away from the gonad (testis, ovary) toward the heart. Females : ovarian vein Males : testicular vein [WP,unvetted]." [Wikipedia:Gonadal_vein] synonym: "gonad vein" EXACT [OBOL:automatic] synonym: "gonada vein" EXACT [OBOL:automatic] synonym: "vein of gonad" EXACT [OBOL:automatic] synonym: "vein of gonada" EXACT [OBOL:automatic] xref: EHDAA2:0000719 xref: EHDAA:8703 xref: SCTID:278192008 xref: VHOG:0001340 xref: Wikipedia:Gonadal_vein is_a: UBERON:0001638 ! vein intersection_of: UBERON:0001638 ! vein intersection_of: RO:0002371 UBERON:0000991 ! attached to gonad relationship: RO:0002371 UBERON:0000991 ! attached to gonad property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/d/da/Gray1120.png" xsd:anyURI property_value: skos:prefLabel "gonadal vein" xsd:string [Term] id: UBERON:0003849 name: mesencephalic neural crest def: "A neural crest that has_potential_to_developmentally_contribute_to a midbrain." [OBOL:automatic] subset: efo_slim subset: vertebrate_core synonym: "mesencephalic neural crest" EXACT [ZFA:0000935] synonym: "neural crest midbrain" EXACT [ZFA:0000935] xref: EFO:0003591 xref: EHDAA2:0001101 xref: EHDAA:360 xref: TAO:0000935 xref: VHOG:0000796 xref: ZFA:0000935 is_a: UBERON:0002342 ! neural crest is_a: UBERON:0003099 {source="ZFA"} ! cranial neural crest intersection_of: UBERON:0002342 ! neural crest intersection_of: RO:0002385 UBERON:0001891 ! has potential to developmentally contribute to midbrain relationship: RO:0002385 UBERON:0001891 ! has potential to developmentally contribute to midbrain property_value: skos:prefLabel "mesencephalic neural crest" xsd:string [Term] id: UBERON:0003850 name: telencephalon neural crest def: "A neural crest that has_potential_to_developmentally_contribute_to a telencephalon." [OBOL:automatic] subset: efo_slim subset: vertebrate_core synonym: "neural crest telencephalon" EXACT [ZFA:0000812] xref: EFO:0003574 xref: RETIRED_EHDAA2:0001991 xref: TAO:0000812 xref: VHOG:0000799 xref: ZFA:0000812 is_a: UBERON:0002342 ! neural crest intersection_of: UBERON:0002342 ! neural crest intersection_of: RO:0002385 UBERON:0001893 ! has potential to developmentally contribute to telencephalon relationship: RO:0002385 UBERON:0001893 ! has potential to developmentally contribute to telencephalon property_value: skos:prefLabel "telencephalon neural crest" xsd:string [Term] id: UBERON:0003851 name: diencephalon neural crest def: "A neural crest that has_potential_to_developmentally_contribute_to a diencephalon." [OBOL:automatic] subset: efo_slim synonym: "diencephalic neural crest" EXACT [ZFA:0000811] synonym: "future diencephalon neural crest" EXACT [EHDAA2:0000603] synonym: "neural crest diencephalon" EXACT [ZFA:0000811] synonym: "neural crest of future diencephalon" EXACT [EMAPA:16518] xref: EFO:0003573 xref: EHDAA2:0000603 xref: EMAPA:16518 xref: TAO:0000811 xref: VHOG:0000798 xref: ZFA:0000811 is_a: UBERON:0002342 ! neural crest intersection_of: UBERON:0002342 ! neural crest intersection_of: RO:0002385 UBERON:0001894 ! has potential to developmentally contribute to diencephalon relationship: RO:0002385 UBERON:0001894 ! has potential to developmentally contribute to diencephalon property_value: skos:prefLabel "diencephalon neural crest" xsd:string [Term] id: UBERON:0003852 name: rhombencephalon neural crest def: "A neural crest that has_potential_to_developmentally_contribute_to a hindbrain." [OBOL:automatic] subset: vertebrate_core synonym: "neural crest hindbrain" EXACT [ZFA:0007063] synonym: "rhombencephalic neural crest" EXACT [ZFA:0007063] synonym: "rhombomere neural crest" RELATED [EMAPA:35747] xref: EHDAA2:0001628 xref: EHDAA:362 xref: EMAPA:35747 xref: TAO:0007063 xref: VHOG:0001210 xref: ZFA:0007063 is_a: UBERON:0002342 ! neural crest is_a: UBERON:0003099 {source="ZFA"} ! cranial neural crest intersection_of: UBERON:0002342 ! neural crest intersection_of: RO:0002385 UBERON:0002028 ! has potential to developmentally contribute to hindbrain relationship: RO:0002385 UBERON:0002028 ! has potential to developmentally contribute to hindbrain property_value: skos:prefLabel "rhombencephalon neural crest" xsd:string [Term] id: UBERON:0003853 name: spinal cord neural crest def: "A neural crest that has_potential_to_developmentally_contribute_to a spinal cord." [OBOL:automatic] synonym: "neural crest spinal cord" EXACT [VHOG:0001006] synonym: "spinal neural crest" RELATED [VHOG:0001006] xref: EHDAA:696 xref: EMAPA:16163 xref: EMAPA:16881 xref: VHOG:0001006 is_a: UBERON:0002342 ! neural crest intersection_of: UBERON:0002342 ! neural crest intersection_of: RO:0002385 UBERON:0002240 ! has potential to developmentally contribute to spinal cord relationship: RO:0002385 UBERON:0002240 ! has potential to developmentally contribute to spinal cord property_value: skos:prefLabel "spinal cord neural crest" xsd:string [Term] id: UBERON:0003854 name: spinal cord neural plate def: "A neural plate that develops_from a future spinal cord." [OBOL:automatic] synonym: "neural plate of spinal cord" EXACT [OBOL:automatic] xref: FMA:312957 xref: TAO:0007021 xref: VHOG:0000439 xref: ZFA:0007021 is_a: UBERON:0003075 ! neural plate intersection_of: UBERON:0003075 ! neural plate intersection_of: RO:0002202 UBERON:0006241 ! develops from future spinal cord relationship: RO:0002202 UBERON:0006241 {source="ZFA"} ! develops from future spinal cord property_value: skos:prefLabel "spinal cord neural plate" xsd:string [Term] id: UBERON:0003855 name: gonad mesenchyme def: "Mesenchyme that is part of a developing gonad [Automatically generated definition]." [OBOL:automatic] subset: pheno_slim synonym: "gonada mesenchyme" EXACT [OBOL:automatic] synonym: "mesenchyme of gonad" EXACT [OBOL:automatic] synonym: "mesenchyme of gonada" EXACT [OBOL:automatic] xref: EHDAA:5012 xref: EMAPA:16858 xref: EMAPA:17385 xref: VHOG:0001090 is_a: UBERON:0003104 ! mesenchyme is_a: UBERON:0005156 ! reproductive structure intersection_of: UBERON:0003104 ! mesenchyme intersection_of: BFO:0000050 UBERON:0000991 ! part of gonad relationship: BFO:0000050 UBERON:0000991 ! part of gonad property_value: skos:prefLabel "gonad mesenchyme" xsd:string [Term] id: UBERON:0003856 name: uncondensed odontogenic mesenchyme def: "Mesenchyme enclosed by a dental organ that gives rise to an odontogenic papilla." [https://github.com/cerivs/zebrafish-anatomical-ontology/issues/107, https://orcid.org/0000-0002-6601-2165] subset: vertebrate_core synonym: "dental mesenchyme" EXACT [ZFA:0005139] synonym: "dental organ mesenchyme" EXACT [OBOL:automatic] synonym: "enamel organ mesenchyme" EXACT [OBOL:automatic] synonym: "tooth enamel organ mesenchyme" EXACT [OBOL:automatic] synonym: "tooth mesenchyme" EXACT [OBOL:automatic] xref: EMAPA:32891 xref: MA:0003152 xref: TAO:0005139 xref: VHOG_RETIRED:0001444 xref: ZFA:0005139 is_a: UBERON:0007213 ! mesenchyme derived from head neural crest is_a: UBERON:0007529 ! loose mesenchyme tissue intersection_of: UBERON:0007529 ! loose mesenchyme tissue intersection_of: BFO:0000050 UBERON:0008281 ! part of tooth bud relationship: BFO:0000050 UBERON:0008281 ! part of tooth bud relationship: RO:0002202 UBERON:0007213 ! develops from mesenchyme derived from head neural crest relationship: RO:0002220 UBERON:0005176 ! adjacent to tooth enamel organ property_value: IAO:0000116 "we follow ZFA in introducing an additional distinction between the dental papilla and the (uncondensed) mesenchyme. Note that in some species such as zebrafish teeth are not part of the mouth, and sharks have dermal denticles which share similar developmental origins with teeth. For now we assume a NC origin for all and add a taxon restriction to 1st arch mesenchyme" xsd:string [Term] id: UBERON:0003859 name: forelimb mesenchyme def: "Mesenchyme that is part of a developing forelimb [Automatically generated definition]." [OBOL:automatic] synonym: "anteriormost limb mesenchyme" EXACT [OBOL:automatic] synonym: "fore limb mesenchyme" EXACT [OBOL:automatic] synonym: "mesenchyme of anteriormost limb" EXACT [OBOL:automatic] synonym: "mesenchyme of fore limb" EXACT [OBOL:automatic] synonym: "mesenchyme of forelimb" EXACT [OBOL:automatic] synonym: "mesenchyme of superior member" EXACT [OBOL:automatic] synonym: "mesenchyme of upper extremity" EXACT [OBOL:automatic] synonym: "superior member mesenchyme" EXACT [OBOL:automatic] synonym: "upper extremity mesenchyme" EXACT [OBOL:automatic] synonym: "wing mesenchyme" NARROW SENSU [Geisha:syn, NCBITaxon:8782, OBOL:automatic] xref: EMAPA:32628 xref: VHOG:0001109 is_a: UBERON:0009749 ! limb mesenchyme intersection_of: UBERON:0003104 ! mesenchyme intersection_of: BFO:0000050 UBERON:0002102 ! part of forelimb relationship: BFO:0000050 UBERON:0002102 ! part of forelimb [Term] id: UBERON:0003860 name: hindlimb mesenchyme def: "Mesenchyme that is part of a developing hindlimb [Automatically generated definition]." [OBOL:automatic] synonym: "hind limb mesenchyme" EXACT [OBOL:automatic] synonym: "inferior member mesenchyme" EXACT [OBOL:automatic] synonym: "lower extremity mesenchyme" EXACT [OBOL:automatic] synonym: "mesenchyme of hind limb" EXACT [OBOL:automatic] synonym: "mesenchyme of hindlimb" EXACT [OBOL:automatic] synonym: "mesenchyme of inferior member" EXACT [OBOL:automatic] synonym: "mesenchyme of lower extremity" EXACT [OBOL:automatic] xref: EMAPA:32637 xref: VHOG:0001074 is_a: UBERON:0009749 ! limb mesenchyme intersection_of: UBERON:0003104 ! mesenchyme intersection_of: BFO:0000050 UBERON:0002103 ! part of hindlimb relationship: BFO:0000050 UBERON:0002103 ! part of hindlimb [Term] id: UBERON:0003861 name: neural arch def: "Posterior part of a vertebra that consists of a pair of pedicles and a pair of laminae, and supports seven processes: four articular processes, two transverse processes one spinous process[WP]. ZFA: A neural arch encloses the neural canal and typically meets its partner to form a neural spine." [Wikipedia:Vertebral_arch] subset: efo_slim subset: pheno_slim subset: vertebrate_core synonym: "arcus vertebra" EXACT [Wikipedia:Vertebral_arch] synonym: "arcus vertebrae" EXACT OMO:0003004 [Wikipedia:Vertebral_arch] synonym: "arcus vertebrae" RELATED OMO:0003011 [Wikipedia:Vertebral_arch] synonym: "arcus vertebrae (vertebralis)" EXACT [FMA:11946] synonym: "dorsal arcocentrum" EXACT [ZFA:0001066] synonym: "vertebra dorsal arch" RELATED [MA:0001453] synonym: "vertebra neural arch" BROAD SENSU [MA:0001453] xref: AAO:0000725 xref: EFO:0003618 xref: FMA:11946 xref: MA:0001453 xref: NCIT:C32138 xref: SCTID:317373001 xref: TAO:0001066 xref: UMLS:C0223076 {source="ncithesaurus:Arch_of_the_Vertebra"} xref: VHOG:0001670 xref: Wikipedia:Vertebral_arch xref: ZFA:0001066 is_a: UBERON:0002513 ! endochondral bone is_a: UBERON:0010358 ! arch of centrum of vertebra relationship: RO:0002202 UBERON:0006063 ! develops from cartilaginous neural arch property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/3/30/Gray82.png" xsd:anyURI [Term] id: UBERON:0003864 name: middle phalanx of manus def: "A middle phalanx that is part of a finger [Automatically generated definition]." [OBOL:automatic] subset: pheno_slim synonym: "hand middle phalanx" EXACT [MA:0001394] synonym: "middle manual phalanx" EXACT [] synonym: "middle phalanx of finger" EXACT [FMA:75817] synonym: "middle phalanx of hand" EXACT [MA:0001394] synonym: "middle phalanx of manual digit" EXACT [] synonym: "phalanx media manus" EXACT OMO:0003011 [FMA:75817, FMA:TA] xref: EMAPA:37306 {source="MA:th"} xref: FMA:75817 xref: MA:0001394 xref: NCIT:C12863 xref: SCTID:113223004 xref: SCTID:371230003 xref: UMLS:C0223828 {source="ncithesaurus:Middle_Phalanx_of_the_Hand"} is_a: UBERON:0001436 ! phalanx of manus is_a: UBERON:0004301 ! middle phalanx intersection_of: UBERON:0004301 ! middle phalanx intersection_of: BFO:0000050 UBERON:0002389 ! part of manual digit relationship: distally_connected_to UBERON:0001436 ! phalanx of manus relationship: proximally_connected_to UBERON:0001436 ! phalanx of manus [Term] id: UBERON:0003865 name: distal phalanx of manus def: "A distal phalanx that is part of a finger [Automatically generated definition]." [OBOL:automatic] comment: This is typically proximally connected to the middle phalanx of manus, except in some cases such as the manual digit 1 (thumb) of many mammals such as humans, where it connects to the proximal phalanx. It always connects to some phalanx, by definition subset: pheno_slim synonym: "distal manual phalanx" EXACT [] synonym: "distal phalanx of finger" EXACT [FMA:75818] synonym: "distal phalanx of hand" EXACT [] synonym: "distal phalanx of manual digit" EXACT [] synonym: "hand distal phalanx" EXACT [MA:0001388] synonym: "phalanx distalis manus" EXACT OMO:0003011 [FMA:75818, FMA:TA] synonym: "terminal phalanx of hand" EXACT [https://orcid.org/0000-0002-6601-2165] synonym: "ungual phalanx of hand" EXACT [http://www.medilexicon.com/medicaldictionary.php?t=67679] xref: EMAPA:35393 xref: FMA:75818 xref: MA:0001388 xref: NCIT:C52784 xref: SCTID:182001007 xref: SCTID:361782004 xref: UMLS:C1269782 {source="ncithesaurus:Distal_Phalanx_of_Hand"} is_a: UBERON:0001436 ! phalanx of manus is_a: UBERON:0004300 ! distal phalanx intersection_of: UBERON:0004300 ! distal phalanx intersection_of: BFO:0000050 UBERON:0002389 ! part of manual digit relationship: BFO:0000050 UBERON:0009552 ! part of distal segment of manual digit relationship: proximally_connected_to UBERON:0001436 ! phalanx of manus [Term] id: UBERON:0003866 name: middle phalanx of pes def: "A middle phalanx that is part of a toe [Automatically generated definition]." [OBOL:automatic] subset: pheno_slim synonym: "foot middle phalanx" EXACT [MA:0001386] synonym: "middle pedal phalanx" EXACT [] synonym: "middle phalanx of foot" EXACT [] synonym: "middle phalanx of toe" EXACT [FMA:75829] synonym: "phalanx media pedis" EXACT OMO:0003011 [FMA:75829, FMA:TA] xref: EMAPA:37311 {source="MA:th"} xref: FMA:75829 xref: MA:0001386 xref: SCTID:83207005 is_a: UBERON:0001449 ! phalanx of pes is_a: UBERON:0004301 ! middle phalanx intersection_of: UBERON:0004301 ! middle phalanx intersection_of: BFO:0000050 UBERON:0001466 ! part of pedal digit relationship: distally_connected_to UBERON:0001449 ! phalanx of pes relationship: proximally_connected_to UBERON:0001449 ! phalanx of pes [Term] id: UBERON:0003867 name: distal phalanx of pes def: "A distal phalanx that is part of a pedal digit [Automatically generated definition]." [OBOL:automatic] comment: This is typically proximally connected to the middle phalanx of pes, except in some cases such as the pedal digit 1 (big toe) in many mammals such as humans, where it connects to the proximal phalanx. It always connects to some phalanx, by definition subset: pheno_slim synonym: "distal pedal phalanx" EXACT [] synonym: "distal phalanx of foot" EXACT [] synonym: "distal phalanx of toe" EXACT [FMA:75830] synonym: "foot distal phalanx" EXACT [MA:0001380] synonym: "phalanx distalis pedis" EXACT OMO:0003011 [FMA:75830, FMA:TA] synonym: "terminal phalanx of foot" EXACT [https://orcid.org/0000-0002-6601-2165] synonym: "terminal phalanx of hindlimb" EXACT [https://orcid.org/0000-0002-6601-2165] synonym: "ungual phalanx of foot" EXACT [http://www.medilexicon.com/medicaldictionary.php?t=67679] synonym: "ungual phalanx of hindlimb" EXACT [http://www.medilexicon.com/medicaldictionary.php?t=67679] xref: EMAPA:37310 {source="MA:th"} xref: FMA:75830 xref: MA:0001380 xref: NCIT:C52783 xref: SCTID:361797001 xref: UMLS:C0224026 {source="ncithesaurus:Distal_Phalanx_of_Foot"} is_a: UBERON:0001449 ! phalanx of pes is_a: UBERON:0004300 ! distal phalanx intersection_of: UBERON:0004300 ! distal phalanx intersection_of: BFO:0000050 UBERON:0001466 ! part of pedal digit relationship: BFO:0000050 UBERON:0009553 ! part of distal segment of pedal digit relationship: proximally_connected_to UBERON:0001449 ! phalanx of pes [Term] id: UBERON:0003868 name: proximal phalanx of pes def: "A proximal phalanx that is part of a pedal digit [Automatically generated definition]." [OBOL:automatic] subset: pheno_slim synonym: "foot proximal phalanx" EXACT [MA:0001387] synonym: "phalanx proximalis pedis" EXACT OMO:0003011 [FMA:75828, FMA:TA] synonym: "proximal pedal phalanx" EXACT [] synonym: "proximal phalanx of foot" EXACT [] synonym: "proximal phalanx of foot digit" EXACT [] synonym: "proximal phalanx of hind digit" EXACT [] synonym: "proximal phalanx of pes" EXACT [] synonym: "proximal phalanx of toe" EXACT [FMA:75828] xref: EMAPA:37312 {source="MA:th"} xref: FMA:75828 xref: MA:0001387 xref: NCIT:C52785 xref: SCTID:85533000 xref: UMLS:C0224020 {source="ncithesaurus:Proximal_Phalanx_of_Foot"} is_a: UBERON:0001449 ! phalanx of pes is_a: UBERON:0004302 ! proximal phalanx intersection_of: UBERON:0004302 ! proximal phalanx intersection_of: BFO:0000050 UBERON:0001466 ! part of pedal digit relationship: proximally_connected_to UBERON:0001448 ! metatarsal bone [Term] id: UBERON:0003869 name: presumptive ganglion def: "A presumptive structure that has the potential to develop into a ganglion." [OBOL:automatic] is_a: UBERON:0006598 ! presumptive structure intersection_of: UBERON:0006598 ! presumptive structure intersection_of: RO:0002387 UBERON:0000045 ! has potential to develop into ganglion relationship: RO:0002387 UBERON:0000045 ! has potential to develop into ganglion property_value: skos:prefLabel "presumptive ganglion" xsd:string [Term] id: UBERON:0003876 name: hippocampal field def: "A part or parts of the hippocampus that have a particular function." [MGI:csmith, MP:0008262] subset: non_informative subset: pheno_slim synonym: "hippocampal region" RELATED [BAMS:HIP] synonym: "hippocampus region" RELATED [MA:0002428] synonym: "hippocampus subdivision" EXACT [FMA:74041] synonym: "subdivision of hippocampus" EXACT [FMA:74041] xref: BAMS:Hi/CA xref: BAMS:HIP xref: EMAPA:32772 xref: FMA:74041 xref: MA:0002428 is_a: UBERON:0002616 ! regional part of brain disjoint_from: UBERON:0007688 ! anlage relationship: BFO:0000050 UBERON:0002421 ! part of hippocampal formation relationship: RO:0002433 UBERON:0001954 ! contributes to morphology of Ammon's horn property_value: skos:prefLabel "hippocampal field" xsd:string [Term] id: UBERON:0003883 name: CA3 field of hippocampus def: "Part of hippocampus proper bounded by the hilus of the dentate gyrus and area CA2, characterized by large pyramidal cells and a dense projection from dentate gyrus granule cell mossy fibers." [http://neurolex.org/wiki/Category\:CA3] subset: efo_slim subset: pheno_slim synonym: "CA3" EXACT [] synonym: "CA3" RELATED [Wikipedia:Region_III_of_hippocampus_proper] synonym: "CA3 field" EXACT [] synonym: "CA3 field of Ammon's horn" EXACT [] synonym: "CA3 field of cornu ammonis" EXACT [] synonym: "CA3 field of hippocampus" EXACT [] synonym: "CA3 field of the Ammon horn" RELATED [BAMS:CA3] synonym: "CA3 field of the hippocampus" RELATED [NeuroNames:185] synonym: "cornu Ammonis 3" RELATED OMO:0003011 [NeuroNames:185] synonym: "field CA3" RELATED [NeuroNames:185] synonym: "field CA3 of hippocampus" RELATED [NeuroNames:185] synonym: "field CA3, Ammon's horn (Lorente de Ns)" RELATED [NeuroNames:185] synonym: "hippocampus CA3" EXACT [] synonym: "regio hippocampi proprii III" RELATED OMO:0003011 [Wikipedia:Region_III_of_hippocampus_proper] synonym: "regio III cornus ammonis" EXACT OMO:0003011 [FMA:74045, FMA:TA] synonym: "regio III cornus ammonis" RELATED OMO:0003011 [Wikipedia:Region_III_of_hippocampus_proper] synonym: "regio III hippocampi proprii" EXACT OMO:0003011 [FMA:74045, FMA:TA] synonym: "regio inferior" EXACT [BIRNLEX:1204] synonym: "region 3 of Ammon's horn" EXACT [] synonym: "region CA3" RELATED [NeuroNames:185] synonym: "region III of ammon's horn" EXACT [FMA:74045] synonym: "region III of hippocampus proper" EXACT [FMA:74045] xref: BAMS:CA3 xref: BIRNLEX:1204 xref: DHBA:10299 xref: DMBA:16141 xref: EFO:0002456 xref: EMAPA:32770 xref: FMA:74045 xref: HBA:12894 xref: MA:0000952 xref: MBA:463 xref: NCIT:C32248 xref: neuronames:185 {source="BIRNLEX:1204"} xref: PBA:10068 xref: UMLS:C0694600 {source="BIRNLEX:1204", source="ncithesaurus:CA3_Field_of_the_Cornu_Ammonis"} xref: Wikipedia:Region_III_of_hippocampus_proper is_a: UBERON:0003876 ! hippocampal field property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/a/ab/HippocampalRegions.jpg" xsd:anyURI property_value: skos:prefLabel "CA3 field of hippocampus" xsd:string [Term] id: UBERON:0003884 name: CA4 field of hippocampus def: "The last of four regions in the cornu ammonis of the hippocampus and is also part of the hilus of the dentate gyrus. This area contains mostly mossy cells that receive inputs from the dentate gyrus and pyramidal cells in the CA3 region and also projects back to the dentate gyrus." [ncithesaurus:CA4_Field_of_the_Cornu_Ammonis] subset: efo_slim subset: pheno_slim synonym: "CA4" EXACT [] synonym: "CA4 field" EXACT [] synonym: "CA4 field of Ammon's horn" EXACT [] synonym: "CA4 field of cornu ammonis" EXACT [] synonym: "hippocampus CA4" EXACT [] synonym: "regio IV cornus ammonis" EXACT OMO:0003011 [FMA:75741, FMA:TA] synonym: "regio IV hippocampi proprii" EXACT OMO:0003011 [FMA:75741, FMA:TA] synonym: "region 4 of Ammon's horn" EXACT [] synonym: "region IV of ammon's horn" EXACT [FMA:75741] synonym: "region IV of hippocampus proper" EXACT [FMA:75741] xref: DHBA:10300 xref: EFO:0002457 xref: EMAPA:32771 xref: FMA:75741 xref: HBA:12895 xref: MA:0000953 xref: NCIT:C32249 xref: neuronames:181 xref: PBA:10074 xref: UMLS:C2328406 {source="ncithesaurus:CA4_Field_of_the_Cornu_Ammonis"} xref: Wikipedia:Region_IV_of_hippocampus_proper is_a: UBERON:0003876 ! hippocampal field property_value: IAO:0000116 "consider obsoleting. consider - CA3c, hilus" xsd:string property_value: skos:prefLabel "CA4 field of hippocampus" xsd:string [Term] id: UBERON:0003885 name: mesometrium def: "A mesentery that is part of a uterus [Automatically generated definition]." [OBOL:automatic] subset: human_reference_atlas synonym: "mesentery of uterus" RELATED [FMA:19816, http://www.vivo.colostate.edu/hbooks/pathphys/misc_topics/peritoneum.html, MA:0002931] xref: EMAPA:35562 xref: FMA:19816 xref: MA:0002931 xref: SCTID:250172001 xref: Wikipedia:Mesometrium is_a: UBERON:0001297 ! serosa of uterus is_a: UBERON:0002095 ! mesentery intersection_of: UBERON:0002095 ! mesentery intersection_of: BFO:0000050 UBERON:0000995 ! part of uterus relationship: BFO:0000050 UBERON:0012332 ! part of broad ligament of uterus property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0003886 name: future coelemic cavity lumen def: "An anatomical cavity that has the potential to develop into a coelemic cavity lumen." [OBOL:automatic] subset: grouping_class subset: non_informative synonym: "body cavity precursor" RELATED [] synonym: "future coelomic cavity lumen" EXACT [] is_a: UBERON:0000464 ! anatomical space intersection_of: UBERON:0000464 ! anatomical space intersection_of: RO:0002387 UBERON:0002323 ! has potential to develop into coelemic cavity lumen relationship: BFO:0000050 UBERON:0000926 ! part of mesoderm relationship: RO:0002387 UBERON:0002323 ! has potential to develop into coelemic cavity lumen relationship: RO:0002488 UBERON:0000109 ! existence starts during gastrula stage relationship: RO:0002492 UBERON:0000111 ! existence ends during organogenesis stage property_value: skos:prefLabel "future coelemic cavity lumen" xsd:string [Term] id: UBERON:0003887 name: intraembryonic coelom def: "The part of the coelom in the embryo between the somatopleuric and splanchnopleuric mesoderm; the principal body cavities of the trunk (thoracic, abdominal, and pelvic) arise from this embryonic part of the coelom." [MGI:anna, MP:0012187] subset: pheno_slim synonym: "somatic coelom" EXACT [Wikipedia:Intraembryonic_coelom] xref: EHDAA:251 xref: EMAPA:16088 xref: NCIT:C34195 xref: UMLS:C1512940 {source="ncithesaurus:Intraembryonic_Coelom"} xref: VHOG:0000316 xref: Wikipedia:Intraembryonic_coelom is_a: BFO:0000002 is_a: UBERON:0002050 ! embryonic structure relationship: BFO:0000050 UBERON:0011997 ! part of coelom relationship: RO:0002202 UBERON:0003081 {source="Wikipedia"} ! develops from lateral plate mesoderm property_value: IAO:0000116 "consider merging with coelom. TODO - add spatial relationships to halves of LPM. Note the OG places XAO and ZFA coelem terms here. editor note: TODO check ZFA, which appears to be a structure present in adults" xsd:string property_value: skos:prefLabel "intraembryonic coelom" xsd:string [Term] id: UBERON:0003889 name: fallopian tube def: "Initial section of the oviduct through which the ova pass from the ovary to the uterus." [http://orcid.org/0000-0002-6601-2165, MGI:smb, MP:0003574] subset: efo_slim subset: human_reference_atlas subset: pheno_slim subset: uberon_slim synonym: "fallopian tubes" RELATED OMO:0003004 [] synonym: "female paramesonephric duct" RELATED [EHDAA2:0000504] synonym: "mammalian oviduct" BROAD [https://sourceforge.net/p/geneontology/ontology-requests/8397/] synonym: "paramesonephric duct of female" RELATED [EMAPA:35660] synonym: "salpinges" BROAD OMO:0003004 [] synonym: "salpinx" BROAD [] synonym: "tuba uterina" RELATED OMO:0003011 [Wikipedia:Fallopian_tube] synonym: "uterine tube (sensu Mammalia)" EXACT [] xref: CALOHA:TS-0732 xref: EHDAA2:0000504 xref: EMAPA:35660 xref: EV:0100112 xref: FMA:18245 xref: GAID:365 xref: galen:FallopianTube xref: MA:0000385 xref: MESH:D005187 xref: NCIT:C12403 xref: SCTID:181463001 xref: UMLS:C0015560 {source="ncithesaurus:Fallopian_Tube"} xref: Wikipedia:Fallopian_tube is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0013515 ! subdivision of oviduct is_a: UBERON:0015212 ! lateral structure relationship: BFO:0000050 UBERON:0002355 ! part of pelvic region of trunk relationship: BSPO:0000126 UBERON:0003975 {source="FMA-abduced-lr"} ! internal female genitalia relationship: RO:0002176 UBERON:0000995 ! connects uterus relationship: RO:0002176 UBERON:0003984 ! connects uterine tube infundibulum relationship: RO:0002202 UBERON:0003890 ! develops from Mullerian duct property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/6/68/Scheme_female_reproductive_system-en.svg" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0003890 name: Mullerian duct def: "Paired ducts of the embryo that run down the lateral sides of the urogenital ridge and terminate at the mullerian eminence in the primitive urogenital sinus. In the female, they will develop to form the fallopian tubes, uterus, and the upper portion of the vagina; in the male, they are lost. These ducts are made of tissue of mesodermal origin[WP]. develops either by lengthwise splitting of the archinephric duct (in chondrichthyans and some amphibians) or by a elongated invagination of the coelomic epithelium (other vertebrates) In males, the oviducts regress. The cranial end of the oviduct maintains an opening into the coelom (which primitively may have been the anteriormost coelomic funnels connecting the nephrocoel with the coelom). This opening is the ostium tubae[USM]." [GO:0061205, http://www.usm.maine.edu/bio/courses/bio205/bio205_26_sex.html, Wikipedia:Paramesonephric_duct] subset: pheno_slim synonym: "ductus paramesonephricus" EXACT [] synonym: "early paramesonephric duct" NARROW [EHDAA2:0004048] synonym: "Muellerian duct" EXACT [] synonym: "Müllerian duct" EXACT [] synonym: "paramesonephric duct" EXACT [EMAPA:27665] xref: AAO:0010141 xref: EHDAA2:0004048 xref: EMAPA:27665 xref: GAID:1309 xref: MESH:D009095 xref: NCIT:C13260 xref: RETIRED_EHDAA2:0001399 xref: SCTID:308802006 xref: UMLS:C0026732 {source="ncithesaurus:Mullerian_Duct"} xref: VHOG:0001199 xref: Wikipedia:Paramesonephric_duct xref: XAO:0000330 is_a: UBERON:0000025 ! tube is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0015212 ! lateral structure relationship: BSPO:0000126 UBERON:0000922 ! embryo relationship: RO:0002202 UBERON:0003064 {source="Wikipedia"} ! develops from intermediate mesoderm property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/6/6d/Gray1109.png" xsd:anyURI [Term] id: UBERON:0003891 name: stroma def: "Connective, non-functional supportive framework of a biological cell, tissue, or organ. Contrast with parenchyma." [http://orcid.org/0000-0002-6601-2165] subset: grouping_class synonym: "stromal connective tissue" RELATED [] xref: FMA:81494 xref: NCIT:C67387 xref: UMLS:C0927195 {source="ncithesaurus:Stroma_Connective_Tissue"} is_a: UBERON:0000064 ! organ part relationship: RO:0002473 UBERON:0002384 ! composed primarily of connective tissue [Term] id: UBERON:0003893 name: capsule def: "A cover or envelope partly or wholly surrounding a structure. Examples: egg shell, articular capsules, renal capsules[WP]." [Wikipedia:Capsule_(anatomy)] comment: see also: protective structure surrounding some species of bacteria and fungi. Note that FMA has classes such as Articular capsule that are not subtypes of Capsule (which is undefined in FMA). GO has 'capsule' which is a fungal structure, and 'external encapsulating structure' which is restricted to cells subset: grouping_class subset: non_informative xref: EHDAA:4739 xref: EHDAA:9061 xref: FMA:85272 xref: galen:Capsule xref: Wikipedia:Capsule_(anatomy) is_a: UBERON:0000158 ! membranous layer [Term] id: UBERON:0003894 name: liver primordium def: "A small endodermal thickening in the foregut adjacent to the transverse septum. Invaginates forming the hepatic diverticulum." [ISBN:3211492755] subset: efo_slim subset: pheno_slim subset: vertebrate_core synonym: "embryological hepatic plate" EXACT [https://orcid.org/0000-0002-6601-2165] synonym: "hepatic plate" RELATED [EHDAA2:0000744] synonym: "liver bud" RELATED INCONSISTENT [XAO:0003266, ZFA:0000124] synonym: "liver endoderm" RELATED [EFO:0002577] synonym: "primordium of the liver" EXACT [ncithesaurus:Primordium_of_the_Liver] xref: AAO:0011058 xref: BTO:0003391 xref: EFO:0002577 xref: EFO:0003428 xref: EHDAA2:0000744 xref: EHDAA:973 xref: EMAPA:16847 xref: NCIT:C34277 xref: TAO:0000124 xref: UMLS:C0734013 {source="ncithesaurus:Hepatic_Cord"} xref: UMLS:C1514451 {source="ncithesaurus:Primordium_of_the_Liver"} xref: XAO:0003266 xref: ZFA:0000124 is_a: UBERON:0000485 {source="EHDAA2"} ! simple columnar epithelium is_a: UBERON:0001048 {source="XAO"} ! primordium is_a: UBERON:0005291 ! embryonic tissue is_a: UBERON:0006598 ! presumptive structure is_a: UBERON:0009497 ! epithelium of foregut-midgut junction intersection_of: UBERON:0001048 ! primordium intersection_of: RO:0002387 UBERON:0002107 ! has potential to develop into liver relationship: BFO:0000050 UBERON:0009550 {source="EHDAA2"} ! part of endoderm of foregut-midgut junction relationship: RO:0002202 UBERON:0001041 ! develops from foregut relationship: RO:0002387 UBERON:0002107 ! has potential to develop into liver property_value: IAO:0000116 "consider adding further subdivisions of the endoderm, e.g. ventral foregut. Note we place two EFO classes here, it's not clear how they differ" xsd:string property_value: skos:prefLabel "liver primordium" xsd:string [Term] id: UBERON:0003897 name: axial muscle def: "One of the skeletal muscles of the head and neck, spine, and ribs." [HP:0003327] subset: pheno_slim xref: EHDAA:5982 xref: EMAPA:18167 xref: MA:0003153 xref: RETIRED_EHDAA2:0000160 xref: TAO:0001954 is_a: UBERON:0014892 ! skeletal muscle organ, vertebrate intersection_of: UBERON:0014892 ! skeletal muscle organ, vertebrate intersection_of: BFO:0000050 UBERON:0013701 ! part of main body axis intersection_of: RO:0002177 UBERON:0005944 ! attached to part of axial skeleton plus cranial skeleton relationship: BFO:0000050 UBERON:0013700 ! part of axial musculature relationship: RO:0002177 UBERON:0005944 ! attached to part of axial skeleton plus cranial skeleton property_value: skos:prefLabel "axial muscle" xsd:string [Term] id: UBERON:0003898 name: skeletal muscle tissue of trunk def: "A portion of skeletal muscle tissue in the trunk." [http://orcid.org/0000-0002-6601-2165] synonym: "skeletal muscle of torso" EXACT [OBOL:automatic] synonym: "skeletal muscle tissue of torso" EXACT [OBOL:automatic] synonym: "skeletal muscle tissue of trunk" EXACT [OBOL:automatic] synonym: "torso skeletal muscle" EXACT [OBOL:automatic] synonym: "torso skeletal muscle tissue" EXACT [OBOL:automatic] synonym: "trunk skeletal muscle" EXACT [OBOL:automatic] synonym: "trunk skeletal muscle tissue" EXACT [OBOL:automatic] xref: SCTID:244848007 is_a: UBERON:0001134 ! skeletal muscle tissue intersection_of: UBERON:0001134 ! skeletal muscle tissue intersection_of: BFO:0000050 UBERON:0002100 ! part of trunk relationship: BFO:0000050 UBERON:0004479 {source="https://github.com/obophenotype/uberon/wiki/Inferring-part-of-relationships"} ! part of musculature of trunk relationship: BFO:0000050 UBERON:0013700 ! part of axial musculature property_value: skos:prefLabel "skeletal muscle tissue of trunk" xsd:string [Term] id: UBERON:0003902 name: retinal neural layer def: "The part of the retina that contains neurons and photoreceptor cells[GO]." [GO:0003407] subset: human_reference_atlas subset: pheno_slim subset: vertebrate_core synonym: "neural layer of retina" EXACT [FMA:58628] synonym: "neural retina" EXACT [XAO:0003216, ZFA:0000046] synonym: "neural retinal epithelium" RELATED [MA:000027] synonym: "neuroretina" EXACT [ZFA:0000046] synonym: "stratum nervosum (retina)" EXACT [FMA:58628] synonym: "stratum nervosum retinae" EXACT OMO:0003011 [FMA:58628, FMA:TA] xref: AAO:0011095 xref: BTO:0000929 xref: CALOHA:TS-0685 xref: EHDAA2:0001253 xref: EHDAA:4763 xref: EMAPA:17171 xref: EMAPA:18590 xref: FMA:58628 xref: MA:0000277 xref: NCIT:C33166 xref: TAO:0000046 xref: UMLS:C1518263 {source="ncithesaurus:Neural_Retina"} xref: VHOG:0000535 xref: XAO:0003216 xref: ZFA:0000046 is_a: UBERON:0001781 ! layer of retina is_a: UBERON:0004121 ! ectoderm-derived structure intersection_of: UBERON:0001781 ! layer of retina intersection_of: RO:0002495 UBERON:0005425 ! immediate transformation of presumptive neural retina relationship: BFO:0000051 CL:0000210 ! has part photoreceptor cell relationship: RO:0002256 UBERON:0005426 ! developmentally induced by lens vesicle relationship: RO:0002495 UBERON:0005425 {source="Bgee:AN"} ! immediate transformation of presumptive neural retina property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "retinal neural layer" xsd:string [Term] id: UBERON:0003909 name: sinusoid def: "Small blood vessel similar to a capillary but with a fenestrated endothelium. Sinusoids are found in the liver, lymphoid tissue, endocrine organs, and hematopoietic organs such as the bone marrow and the spleen. Sinusoids found within terminal villi of the placenta are not comparable to these; they possess a continuous endothelium and complete basal lamina[WP]." [Wikipedia:Sinusoid_(blood_vessel)] subset: vertebrate_core synonym: "endothelium of irregular blood filled space" RELATED [] synonym: "sinusoidal blood vessel" EXACT [] synonym: "sinusoidal blood vessel endothelium" EXACT [ZFA:0005261] synonym: "sinusoidal capillary" RELATED [http://www.medilexicon.com/medicaldictionary.php?t=13986] synonym: "sinusoidal endothelium" RELATED [] xref: FMA:63131 xref: SCTID:340163004 xref: TAO:0005261 xref: Wikipedia:Sinusoid_(blood_vessel) xref: ZFA:0005261 is_a: UBERON:2005260 {source="Wikipedia", source="ZFA"} ! fenestrated capillary [Term] id: UBERON:0003910 name: splenic sinusoid def: "Wide vessels in the spleen that drain into trabecular veins[WP]." [Wikipedia:Red_pulp#Sinusoids] subset: human_reference_atlas synonym: "sinusoid of red pulp of spleen" RELATED [FMA:63199] synonym: "sinusoidal blood vessel of spleen" EXACT [OBOL:automatic] xref: FMA:63199 xref: SCTID:9081000 xref: Wikipedia:Red_pulp#Sinusoids is_a: UBERON:0003497 ! abdomen blood vessel is_a: UBERON:0003909 ! sinusoid intersection_of: UBERON:0003909 ! sinusoid intersection_of: BFO:0000050 UBERON:0001250 ! part of red pulp of spleen relationship: BFO:0000050 UBERON:0001250 ! part of red pulp of spleen relationship: RO:0002162 NCBITaxon:40674 ! in taxon Mammalia relationship: RO:0002170 UBERON:0010400 ! connected to spleen trabecular vein property_value: RO:0002161 NCBITaxon:10088 {source="http://www.informatics.jax.org/greenbook/chapters/chapter13.shtml"} property_value: RO:0002161 NCBITaxon:9681 {source="http://www.informatics.jax.org/greenbook/chapters/chapter13.shtml"} property_value: RO:0002161 NCBITaxon:9822 {source="http://www.informatics.jax.org/greenbook/chapters/chapter13.shtml"} property_value: RO:0002175 NCBITaxon:10114 {source="http://www.informatics.jax.org/greenbook/chapters/chapter13.shtml"} property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0003911 name: choroid plexus epithelium def: "The epithelial component of the choroid plexus. Consists of cuboidal epithelial cells surrounding a core of capillaries and loose connective tissue." [UBERON:cjm, Wikipedia:Choroid_plexus] synonym: "choroid plexus epithelial tissue" EXACT [OBOL:automatic] synonym: "epithelial tissue of chorioid plexus of cerebral hemisphere" EXACT [OBOL:automatic] synonym: "epithelial tissue of choroid plexus" EXACT [OBOL:automatic] synonym: "epithelium of choroid plexus" EXACT [FMA:242811] xref: EMAPA:36608 xref: FMA:242811 xref: MA:0000824 xref: NCIT:C42079 xref: UMLS:C1516506 {source="ncithesaurus:Choroid_Plexus_Epithelium"} is_a: UBERON:0000483 ! epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: BFO:0000050 UBERON:0001886 ! part of choroid plexus relationship: BFO:0000050 UBERON:0001886 ! part of choroid plexus property_value: skos:prefLabel "choroid plexus epithelium" xsd:string [Term] id: UBERON:0003913 name: tooth-like structure def: "Hard bony, calcareous, or chitinous organ found in the mouth or pharynx of an animal and used in procuring or masticating food." [http://orcid.org/0000-0002-6601-2165] comment: see dermal denticle subset: grouping_class synonym: "tooth-like organ" EXACT [http://orcid.org/0000-0002-6601-2165] xref: HAO:0001019 is_a: UBERON:0004765 ! skeletal element relationship: RO:0002216 GO:0071626 ! capable of part of mastication [Term] id: UBERON:0003914 name: epithelial tube def: "Epithelial tubes transport gases, liquids and cells from one site to another and form the basic structure of many organs and tissues, with tube shape and organization varying from the single-celled excretory organ in Caenorhabditis elegans to the branching trees of the mammalian kidney and insect tracheal system." [GO:0060562, PMID:12526790] synonym: "epithelial or endothelial tube" EXACT [] xref: AEO:0000114 xref: EHDAA2:0003114 xref: FBbt:00007474 {sssom:mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"} is_a: UBERON:0000025 ! tube is_a: UBERON:0000483 ! epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: RO:0000086 PATO:0002299 ! has quality tubular property_value: skos:prefLabel "epithelial tube" xsd:string [Term] id: UBERON:0003915 name: endothelial tube def: "Any endothelium that has the quality of being cylindrical [Automatically generated definition]." [OBOL:automatic] is_a: UBERON:0001986 ! endothelium is_a: UBERON:0003914 ! epithelial tube intersection_of: UBERON:0001986 ! endothelium intersection_of: RO:0000086 PATO:0002299 ! has quality tubular property_value: skos:prefLabel "endothelial tube" xsd:string [Term] id: UBERON:0003918 name: kidney mesenchyme def: "Kidney mesenchyme is the tissue made up of loosely connected mesenchymal cells in the kidney[GO]." [GO:0072074] subset: pheno_slim synonym: "mesenchyme of kidney" EXACT [] is_a: UBERON:0003104 ! mesenchyme intersection_of: UBERON:0003104 ! mesenchyme intersection_of: RO:0002387 UBERON:0002113 ! has potential to develop into kidney relationship: RO:0002387 UBERON:0002113 ! has potential to develop into kidney property_value: IAO:0000116 "check this" xsd:string [Term] id: UBERON:0003920 name: venous blood vessel def: "A blood vessel that carries blood from the capillaries toward the heart." [http://www.thefreedictionary.com/venous+blood+vessel] comment: Compare to: vein subset: human_reference_atlas synonym: "segment of venous tree organ" EXACT [FMA:86188] synonym: "venous tree organ segment" EXACT [FMA:86188] xref: EMAPA:35932 xref: FMA:86188 xref: MA:0000066 is_a: UBERON:0001981 ! blood vessel intersection_of: UBERON:0001981 ! blood vessel intersection_of: BFO:0000050 UBERON:0004582 ! part of venous system relationship: BFO:0000050 UBERON:0004582 ! part of venous system property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "venous blood vessel" xsd:string [Term] id: UBERON:0003921 name: pancreas primordium def: "Embryonic structure that develops into pancreatic bud." [Wikipedia:Pancreas#Embryological_development] subset: efo_slim subset: vertebrate_core synonym: "pancreatic anlage" RELATED [ZFA:0000254] synonym: "pancreatic endoderm" RELATED [EFO:0002579] synonym: "pancreatic primordium" EXACT [] synonym: "primordial pancreas" RELATED [FMA:79792] xref: EFO:0002579 xref: EFO:0003434 xref: EHDAA2:0001382 xref: EHDAA:2163 xref: EMAPA:17066 xref: FMA:79792 xref: TAO:0000254 xref: XAO:0001101 xref: ZFA:0000254 is_a: BFO:0000002 is_a: UBERON:0001048 ! primordium is_a: UBERON:0006598 ! presumptive structure intersection_of: UBERON:0001048 ! primordium intersection_of: RO:0002387 UBERON:0001264 ! has potential to develop into pancreas relationship: BFO:0000050 UBERON:0007026 ! part of presumptive gut relationship: RO:0002202 UBERON:0000925 {source="Wikipedia"} ! develops from endoderm relationship: RO:0002387 UBERON:0001264 ! has potential to develop into pancreas property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/d/db/Gray982.png" xsd:anyURI property_value: skos:prefLabel "pancreas primordium" xsd:string [Term] id: UBERON:0003922 name: pancreatic epithelial bud def: "The embryonic pancreas develops from two separate anlagen in the foregut epithelium, one dorsal and two ventral pancreatic buds[PMID]." [PMID:16417468, Wikipedia:Pancreatic_bud] subset: efo_slim synonym: "pancreas epithelium" RELATED [EMAPA:35645] synonym: "pancreatic anlage" RELATED [] synonym: "pancreatic bud" EXACT [ZFA:0001390] synonym: "pancreatic buds" EXACT OMO:0003004 [TAO:0001390] xref: EFO:0003470 xref: EMAPA:35645 xref: NCIT:C34242 xref: SCTID:360398004 xref: TAO:0001390 xref: UMLS:C1283285 {source="ncithesaurus:Pancreatic_Bud"} xref: Wikipedia:Pancreatic_bud xref: ZFA:0001390 is_a: UBERON:0005291 ! embryonic tissue is_a: UBERON:0005911 ! endo-epithelium is_a: UBERON:0007499 {source="EHDAA2"} ! epithelial sac relationship: BFO:0000050 UBERON:0003921 {source="EHDAA2"} ! part of pancreas primordium relationship: RO:0002202 UBERON:0001041 {source="Wikipedia:Pancreas#Embryological_development"} ! develops from foregut relationship: RO:0002202 UBERON:0001555 ! develops from digestive tract relationship: RO:0002202 UBERON:0002114 ! develops from duodenum relationship: RO:0002202 UBERON:0009497 {source="EHDAA2-inferred"} ! develops from epithelium of foregut-midgut junction property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/4/49/Suckale08FBS_fig1_pancreas_development.jpeg" xsd:anyURI property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/d/db/Gray982.png" xsd:anyURI property_value: skos:prefLabel "pancreatic epithelial bud" xsd:string [Term] id: UBERON:0003923 name: dorsal pancreatic bud def: "Pancreatic bud that gives rise to the accessory pancreatic duct." [Wikipedia:Pancreatic_bud] subset: efo_slim subset: vertebrate_core synonym: "dorsal pancreas anlage" RELATED [] synonym: "dorsal pancreatic anlage" RELATED [] synonym: "pancreas dorsal primordium duct bud" EXACT [EHDAA2:0001385] synonym: "pancreas primordium dorsal bud" EXACT [] synonym: "posterior pancreatic anlage" RELATED [] synonym: "posterior pancreatic bud" RELATED [] synonym: "primary pancreatic bud" EXACT [XAO:0000467] xref: AAO:0011031 xref: EFO:0003465 xref: EHDAA2:0001385 xref: EMAPA:17067 xref: SCTID:361435005 xref: TAO:0001370 xref: VHOG:0001428 xref: Wikipedia:Pancreatic_bud xref: XAO:0000467 xref: ZFA:0001370 is_a: UBERON:0003922 ! pancreatic epithelial bud relationship: BFO:0000050 UBERON:0010375 {source="EHDAA2"} ! part of pancreas dorsal primordium relationship: RO:0002202 UBERON:0001045 {source="XAO"} ! develops from midgut property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/d/db/Gray982.png" xsd:anyURI property_value: skos:prefLabel "dorsal pancreatic bud" xsd:string [Term] id: UBERON:0003924 name: ventral pancreatic bud def: "Pancreatic bud that gives rise to the major pancreatic duct." [Wikipedia:Pancreatic_bud] subset: efo_slim subset: vertebrate_core synonym: "anterior pancreatic anlage" RELATED [] synonym: "anterior pancreatic bud" RELATED [] synonym: "pancreas primordium ventral bud" EXACT [] synonym: "pancreas ventral primordium duct bud" EXACT [EHDAA2:0001389] synonym: "ventral pancreas anlage" RELATED [] synonym: "ventral pancreatic anlage" RELATED [] xref: AAO:0011111 xref: EFO:0003464 xref: EHDAA2:0001389 xref: EMAPA:17256 xref: SCTID:361437002 xref: TAO:0001369 xref: VHOG:0001429 xref: Wikipedia:Pancreatic_bud xref: XAO:0001103 xref: ZFA:0001369 is_a: UBERON:0003922 ! pancreatic epithelial bud relationship: BFO:0000050 UBERON:0010376 {source="EHDAA2"} ! part of pancreas ventral primordium relationship: RO:0002202 UBERON:0008835 {source="PMID:16417468", source="WP"} ! develops from hepatic diverticulum property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/d/db/Gray982.png" xsd:anyURI property_value: skos:prefLabel "ventral pancreatic bud" xsd:string [Term] id: UBERON:0003928 name: digestive system duct def: "A duct that is part of a digestive system [Automatically generated definition]." [OBOL:automatic] synonym: "duct of digestive system" EXACT [OBOL:automatic] synonym: "duct of gastrointestinal system" EXACT [OBOL:automatic] synonym: "gastrointestinal system duct" EXACT [OBOL:automatic] xref: TAO:0005162 xref: ZFA:0005162 is_a: UBERON:0000058 ! duct intersection_of: UBERON:0000058 ! duct intersection_of: BFO:0000050 UBERON:0001007 ! part of digestive system relationship: BFO:0000050 UBERON:0001007 ! part of digestive system property_value: skos:prefLabel "digestive system duct" xsd:string [Term] id: UBERON:0003929 name: digestive tract epithelium def: "An epithelium that lines the lumen of the digestive tract." [http://orcid.org/0000-0002-6601-2165] synonym: "alimentary tract epithelium" RELATED [OBOL:automatic] synonym: "digestive tract epithelial tissue" EXACT [OBOL:automatic] synonym: "epithelial tissue of digestive tract" EXACT [OBOL:automatic] synonym: "epithelial tissue of gut" EXACT [OBOL:automatic] synonym: "epithelium of digestive tract" EXACT [OBOL:automatic] synonym: "epithelium of gut" EXACT [OBOL:automatic] synonym: "gastrodermis" EXACT SENSU [https://orcid.org/0000-0003-3308-6245, NCBITaxon:6073] synonym: "gut epithelial tissue" EXACT [OBOL:automatic] synonym: "gut epithelium" EXACT [EHDAA2:0004567, MA:0003201, ZFA:0005123] xref: BTO:0000956 xref: EHDAA2:0004567 xref: EMAPA:32928 xref: FBbt:00047166 {sssom:mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"} xref: MA:0003201 xref: NCIT:C12963 xref: TAO:0005123 xref: UMLS:C0836205 {source="ncithesaurus:Gut_Epithelium"} xref: XAO:0003200 xref: ZFA:0005123 is_a: UBERON:0000483 ! epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: BFO:0000050 UBERON:0001555 ! part of digestive tract relationship: BFO:0000050 UBERON:0001555 ! part of digestive tract property_value: skos:prefLabel "digestive tract epithelium" xsd:string [Term] id: UBERON:0003931 name: diencephalic white matter def: "White matter that is part of a diencephalon [Automatically generated definition]." [OBOL:automatic] subset: vertebrate_core synonym: "diencephalic tract/commissure" EXACT [ZFA:0000338] synonym: "diencephalic tracts and commissures" EXACT OMO:0003004 [TAO:0000338] synonym: "predominantly white regional part of diencephalon" EXACT [BIRNLEX:1678] synonym: "white matter of diencephalon" EXACT [FMA:83931] xref: BIRNLEX:1678 xref: FMA:83931 xref: TAO:0000338 xref: ZFA:0000338 is_a: UBERON:0019261 ! white matter of forebrain intersection_of: UBERON:0002316 ! white matter intersection_of: BFO:0000050 UBERON:0001894 ! part of diencephalon relationship: BFO:0000050 UBERON:0001894 ! part of diencephalon property_value: skos:prefLabel "diencephalic white matter" xsd:string [Term] id: UBERON:0003932 name: cartilage element of chondrocranium def: "A cartilage element of chondrocranium. Example: neurocranial trabecula." [https://orcid.org/0000-0002-6601-2165] subset: efo_slim synonym: "cartilage of chondrocranium" EXACT [OBOL:accepted] synonym: "cartilaginous element of chondrocranium" EXACT [OBOL:accepted] synonym: "chondrocranium cartilage" EXACT [ZFA:0001461] synonym: "neurocranium cartilage" EXACT [ZFA:0001461] xref: EFO:0003690 xref: TAO:0001461 xref: ZFA:0001461 is_a: UBERON:0003933 ! cranial cartilage intersection_of: UBERON:0007844 ! cartilage element intersection_of: BFO:0000050 UBERON:0002241 ! part of chondrocranium relationship: BFO:0000050 UBERON:0002241 ! part of chondrocranium property_value: skos:prefLabel "cartilage element of chondrocranium" xsd:string [Term] id: UBERON:0003933 name: cranial cartilage def: "A cartilage element that is part of the cranial skeleton." [https://orcid.org/0000-0002-6601-2165, ZFA:0001458] synonym: "cartilage of cranium" EXACT [OBOL:automatic] synonym: "cranial cartilages" RELATED OMO:0003004 [ZFA:0001458] synonym: "cranium cartilage" EXACT [OBOL:automatic] xref: TAO:0001458 xref: ZFA:0001458 is_a: UBERON:0007844 ! cartilage element intersection_of: UBERON:0007844 ! cartilage element intersection_of: BFO:0000050 UBERON:0010323 ! part of cranial skeletal system relationship: BFO:0000050 UBERON:0010323 ! part of cranial skeletal system property_value: skos:prefLabel "cranial cartilage" xsd:string [Term] id: UBERON:0003937 name: reproductive gland def: "Any of the organized aggregations of cells that function as secretory or excretory organs and are associated with reproduction." [MP:0000653] subset: organ_slim subset: pheno_slim synonym: "genitalia gland" EXACT [OBOL:automatic] synonym: "gland of genitalia" EXACT [MP:0000653] synonym: "gland of reproductive system" EXACT [OBOL:automatic] synonym: "reproductive gland" EXACT [MA:0001751] synonym: "reproductive system gland" EXACT [OBOL:automatic] synonym: "sex gland" EXACT [MP:0000653] xref: MA:0001751 is_a: UBERON:0002530 ! gland is_a: UBERON:0005156 ! reproductive structure intersection_of: UBERON:0002530 ! gland intersection_of: BFO:0000050 UBERON:0000990 ! part of reproductive system property_value: skos:prefLabel "reproductive gland" xsd:string [Term] id: UBERON:0003942 name: somatosensory system def: "The sensory system for the sense of touch and pain." [NLXANAT:090818] subset: pheno_slim synonym: "somatic sensory system" EXACT [] synonym: "system for detection of somatic senses" EXACT [] xref: EMAPA:37954 {source="MA:th"} xref: neuronames:2887 xref: NLXANAT:090818 xref: Wikipedia:Somatosensory_system is_a: UBERON:0001032 ! sensory system relationship: RO:0002216 GO:0019233 ! capable of part of sensory perception of pain relationship: RO:0002216 GO:0050975 ! capable of part of sensory perception of touch property_value: skos:prefLabel "somatosensory system" xsd:string [Term] id: UBERON:0003946 name: placenta labyrinth def: "The placental layers where embryonic blood vessels are surrounded by trophoblast cells and maternal blood." [MP:0001716] subset: pheno_slim synonym: "labyrinthine layer" EXACT [GO:0060713] synonym: "labyrinthine layer of placenta" EXACT [GO:0060713] synonym: "placental labyrinth" EXACT [] is_a: UBERON:0005156 ! reproductive structure relationship: BFO:0000050 UBERON:0001987 ! part of placenta relationship: RO:0002433 UBERON:0001987 ! contributes to morphology of placenta property_value: RO:0002161 NCBITaxon:9606 {source="http://placentation.ucsd.edu"} property_value: seeAlso "http://placentation.ucsd.edu/placenta.html" xsd:anyURI [Term] id: UBERON:0003947 name: brain ventricle/choroid plexus def: "The brain ventricles or their associated choroid plexuses." [MP:0002200] subset: pheno_slim is_a: UBERON:0010000 ! multicellular anatomical structure union_of: UBERON:0001886 ! choroid plexus union_of: UBERON:0004086 ! brain ventricle relationship: BFO:0000050 UBERON:0000955 ! part of brain relationship: RO:0002433 UBERON:0000955 ! contributes to morphology of brain property_value: IAO:0000116 "TODO - check relationship between CP and BV. If this is part of then this class should be obsoleted" xsd:string property_value: IAO:0000116 "TODO merge into BV" xsd:string property_value: skos:prefLabel "brain ventricle/choroid plexus" xsd:string [Term] id: UBERON:0003952 name: anterior stroma of cornea def: "The anterior segment of the lamellated connective tissue layer of the cornea." [MP:0003093] subset: human_reference_atlas subset: pheno_slim synonym: "anterior stroma" BROAD [MP:0003093] synonym: "cornea anterior stroma" EXACT [MP:0003093] xref: EMAPA:37414 {source="MA:th"} is_a: UBERON:0003566 ! head connective tissue intersection_of: UBERON:0002384 ! connective tissue intersection_of: BSPO:0000123 UBERON:0001777 ! substantia propria of cornea disjoint_from: UBERON:0003953 {source="lexical"} ! posterior stroma of cornea relationship: BSPO:0000123 UBERON:0001777 ! substantia propria of cornea relationship: RO:0002433 UBERON:0001777 ! contributes to morphology of substantia propria of cornea property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0003953 name: posterior stroma of cornea def: "The posterior segment of the lamellated connective tissue layer of the cornea." [MP:0003094] subset: pheno_slim synonym: "cornea posterior stroma" EXACT [MP:0003094] synonym: "posterior stroma" BROAD [MP:0003094] xref: EMAPA:37415 {source="MA:th"} is_a: UBERON:0003566 ! head connective tissue intersection_of: UBERON:0002384 ! connective tissue intersection_of: BSPO:0000122 UBERON:0001777 ! substantia propria of cornea relationship: BSPO:0000122 UBERON:0001777 ! substantia propria of cornea relationship: RO:0002433 UBERON:0001777 ! contributes to morphology of substantia propria of cornea [Term] id: UBERON:0003956 name: aqueous drainage system def: "The structures associated with drainage of the aqueous humor from the eye, that include the trabecular meshwork, Schlemm's canal, the uveoscleral network, and the aqueous veins." [MP:0005198] subset: pheno_slim xref: EMAPA:37427 {source="MA:th"} is_a: UBERON:0000467 ! anatomical system relationship: BFO:0000050 UBERON:0001768 ! part of uvea [Term] id: UBERON:0003959 name: rete testis def: "An anastomosing network of delicate tubules located in the hilum of the testicle (mediastinum testis) that carries sperm from the seminiferous tubules to the vasa efferentia[WP]." [MP:0006416, Wikipedia:Rete_testis] subset: pheno_slim synonym: "Haller's rete" EXACT [FMA:19834] xref: EMAPA:18332 xref: FMA:19834 xref: GAID:399 xref: MA:0003013 xref: MESH:D012152 xref: NCIT:C33467 xref: SCTID:279617009 xref: UMLS:C0035278 {source="ncithesaurus:Rete_Testis"} xref: Wikipedia:Rete_testis is_a: UBERON:0004111 ! anatomical conduit is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0005156 ! reproductive structure relationship: BFO:0000050 UBERON:0005051 ! part of mediastinum testis relationship: channel_for CL:0000019 ! sperm relationship: channels_from UBERON:0001343 ! seminiferous tubule of testis relationship: channels_into UBERON:0006946 ! efferent duct relationship: RO:0002202 UBERON:0005297 {source="Wikipedia"} ! develops from testis sex cord property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/b/b5/Hodenschema.svg" xsd:anyURI property_value: IAO:0000116 "add more specific classification e.g. anastomosing network - consider FMA:3726" xsd:string [Term] id: UBERON:0003962 name: pterygopalatine ganglion def: "The small parasympathetic ganglion that supplies nerve fibers to the lacrimal, nasal, palatine and pharyngeal glands." [MP:0008314, Wikipedia:Pterygopalatine_ganglion] subset: human_reference_atlas subset: pheno_slim synonym: "g. pterygopalatinum" RELATED OMO:0003011 [Wikipedia:Pterygopalatine_ganglion] synonym: "Meckel ganglion" EXACT [MP:0008314] synonym: "Meckel's ganglion" EXACT [FMA:6965] synonym: "nasal ganglion" EXACT [MP:0008314] synonym: "palatine ganglion" EXACT [MP:0008314] synonym: "pterygopalatine ganglia" EXACT [MP:0008314] synonym: "sphenopalatine ganglion" EXACT [MP:0008314] synonym: "sphenopalatine parasympathetic ganglion" EXACT [EHDAA2:0001889] xref: BAMS:GptVII xref: EHDAA2:0001889 xref: EMAPA:36275 xref: FMA:6965 xref: SCTID:280364004 xref: Wikipedia:Pterygopalatine_ganglion is_a: UBERON:0001808 ! parasympathetic ganglion relationship: RO:0002495 UBERON:0010128 {evidence="definitional"} ! immediate transformation of future pterygopalatine ganglion property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/a/a9/Gray779.png" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0003963 name: otic ganglion def: "The ganglion that supplies nerve fibers to the parotid gland." [MP:0008315, Wikipedia:Otic_ganglion] subset: human_reference_atlas subset: pheno_slim synonym: "Arnold's ganglion" EXACT [FMA:6967] synonym: "ganglion oticum" RELATED OMO:0003011 [Wikipedia:Otic_ganglion] synonym: "otic parasympathetic ganglion" EXACT [EHDAA2:0001335] xref: BAMS:GoIX xref: EHDAA2:0001335 xref: EHDAA:6706 xref: EMAPA:36274 xref: FMA:6967 xref: SCTID:279283005 xref: Wikipedia:Otic_ganglion is_a: UBERON:0001714 ! cranial ganglion is_a: UBERON:0001808 ! parasympathetic ganglion relationship: extends_fibers_into UBERON:0001831 ! parotid gland property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/6/64/Gray783.png" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0003964 name: prevertebral ganglion def: "The sympathetic ganglia located in front of the vertebral column and are associated with the major branches of the abdominal aorta; these include the celiac, aorticorenal, superior and inferior mesenteric ganglia." [ISBN:0-683-40008-8, MP:0008316] subset: human_reference_atlas subset: pheno_slim synonym: "collateral ganglia" RELATED OMO:0003004 [Wikipedia:Prevertebral_ganglia] synonym: "collateral ganglion" EXACT [FMA:5892] synonym: "pre-aortic ganglia" RELATED OMO:0003004 [Wikipedia:Prevertebral_ganglia] synonym: "preaortic ganglia" RELATED OMO:0003004 [Wikipedia:Prevertebral_ganglia] synonym: "prevertebral ganglion" RELATED [Wikipedia:Prevertebral_ganglia] synonym: "prevertebral plexuses" RELATED OMO:0003004 [Wikipedia:Prevertebral_ganglia] synonym: "previsceral ganglion" EXACT [FMA:5892] synonym: "three great gangliated plexuses" RELATED OMO:0003004 [Wikipedia:Prevertebral_ganglia] xref: FMA:5892 xref: MA:0003101 xref: Wikipedia:Prevertebral_ganglia is_a: UBERON:0001806 ! sympathetic ganglion relationship: BSPO:0000102 UBERON:0001130 ! vertebral column property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0003967 name: cutaneous elastic tissue def: "The slender connective tissue fiber in the extracellular matrix of skin tissue that is composed of microfibrils and amorphous elastin and is characterized by great elasticity." [MP:0008418] subset: pheno_slim synonym: "cutaneous elastic fiber" NARROW [MP:0008418] synonym: "dermal elastic fiber" NARROW [MP:0008418] xref: EMAPA:37841 {source="MA:th"} is_a: UBERON:0002521 ! elastic tissue intersection_of: UBERON:0002521 ! elastic tissue intersection_of: BFO:0000050 UBERON:0000014 ! part of zone of skin relationship: BFO:0000050 UBERON:0000014 ! part of zone of skin relationship: RO:0002433 UBERON:0000014 ! contributes to morphology of zone of skin property_value: skos:prefLabel "cutaneous elastic tissue" xsd:string [Term] id: UBERON:0003970 name: placental labyrinth vasculature def: "Blood vessels of the layer of the placenta where embryonic and maternal blood vessels interdigitate." [MP:0008803] subset: pheno_slim synonym: "placental labyrinth vascular network" EXACT [] synonym: "placental vasculature" RELATED [OBOL:automatic] synonym: "vasculature of placenta labyrinth" EXACT [] is_a: UBERON:0006876 ! vasculature of organ intersection_of: UBERON:0002049 ! vasculature intersection_of: BFO:0000050 UBERON:0003946 ! part of placenta labyrinth relationship: BFO:0000050 UBERON:0003946 ! part of placenta labyrinth [Term] id: UBERON:0003975 name: internal female genitalia def: "The internal feminine genital organs, including the ovaries, uterine tubes, uterus, uterine cervix, and vagina." [MP:0009209] comment: TODO: Relabel. Make distinct organ class. See https://github.com/obophenotype/uberon/issues/547 subset: human_reference_atlas subset: organ_slim subset: pheno_slim synonym: "female internal genitalia" EXACT [FMA:45654] synonym: "internal female genital organ" EXACT [BTO:0003099] synonym: "internal genitalia of female reproductive system" EXACT [OBOL:automatic] synonym: "organa genitalia feminina interna" RELATED [BTO:0003099] xref: BTO:0003099 xref: FMA:45654 xref: SCTID:303518005 is_a: UBERON:0003134 ! female reproductive organ is_a: UBERON:0004175 ! internal genitalia intersection_of: UBERON:0004175 ! internal genitalia intersection_of: BFO:0000050 UBERON:0000474 ! part of female reproductive system property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "internal female genitalia" xsd:string [Term] id: UBERON:0003978 name: valve subset: grouping_class synonym: "anatomical valve" EXACT [FMA:67611] xref: EHDAA2:0004046 xref: EHDAA:1892 xref: EHDAA:4406 xref: FMA:67611 xref: galen:Valve is_a: UBERON:0000064 ! organ part relationship: RO:0002215 GO:0065008 ! capable of regulation of biological quality property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/heart-female/v1.3/assets/3d-vh-f-heart.glb" xsd:anyURI property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/heart-male/v1.3/assets/3d-vh-m-heart.glb" xsd:anyURI [Term] id: UBERON:0003980 name: cerebellum fissure def: "One of a set of deep furrows which divide the lobules of the cerebellum. Examples: postcentral, primary and secondary furrows." [MP:0009267] subset: pheno_slim synonym: "cerebellar fissure" EXACT [] synonym: "cerebellar fissures" RELATED OMO:0003004 [BAMS:CBf] synonym: "cerebellar fissures set" RELATED OMO:0003004 [FMA:77789] synonym: "cerebellar sulci" RELATED OMO:0003004 [HBA:9406] synonym: "cerebellar sulcus" RELATED [] synonym: "fissurae cerebelli" EXACT OMO:0003011 [FMA:77789, FMA:TA] synonym: "set of cerebellar fissures" RELATED OMO:0003004 [FMA:77789] synonym: "sulcus of cerebellum" RELATED [] xref: BAMS:CBf xref: DHBA:12828 xref: EMAPA:37818 {source="MA:th"} xref: FMA:321547 xref: HBA:9406 xref: neuronames:1213 xref: SCTID:314163001 is_a: UBERON:0014466 ! subarachnoid fissure intersection_of: UBERON:0014466 ! subarachnoid fissure intersection_of: BFO:0000050 UBERON:0002037 ! part of cerebellum relationship: BFO:0000050 UBERON:0002037 ! part of cerebellum property_value: skos:prefLabel "cerebellum fissure" xsd:string [Term] id: UBERON:0003981 name: primordial ovarian follicle def: "Primordial follicles are indiscernible to the naked eye and develop to primary, secondary, and finally mature vesicular follicles." [MP:0009361] subset: human_reference_atlas subset: pheno_slim synonym: "ovary primordial follicle" EXACT [MA:0001710] synonym: "primordial follicle" EXACT [] xref: EMAPA:30755 xref: MA:0001710 xref: NCIT:C33400 xref: UMLS:C1514441 {source="ncithesaurus:Primordial_Follicle"} is_a: UBERON:0001305 ! ovarian follicle property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0003984 name: uterine tube infundibulum def: "The funnel-like expansion of the abdominal extremity of the uterine tube[MP]." [MP:0009466, Wikipedia:Infundibulum_of_uterine_tube] subset: human_reference_atlas subset: pheno_slim synonym: "infundibulum" BROAD INCONSISTENT [] synonym: "infundibulum of fallopian tube" NARROW [FMA:18307] synonym: "infundibulum of oviduct" EXACT [FMA:18307] synonym: "infundibulum of uterine tube" EXACT [FMA:18307] synonym: "infundibulum tubae uterinae" RELATED OMO:0003011 [Wikipedia:Infundibulum_of_uterine_tube] xref: EMAPA:29897 xref: FMA:18307 xref: SCTID:362262001 xref: Wikipedia:Infundibulum_of_uterine_tube is_a: UBERON:0013515 {source="FMA"} ! subdivision of oviduct relationship: RO:0002162 NCBITaxon:7742 ! in taxon Vertebrata property_value: foaf:depiction "https://upload.wikimedia.org/wikipedia/commons/6/66/Illu_cervix.jpg" xsd:anyURI property_value: RO:0002175 NCBITaxon:8782 property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0003988 name: thymus corticomedullary boundary def: "The dense region demarcating the thymus medulla from the surrounding cortex that is characterized by numerous blood vessels (predominantly arterioles) with some perivascular connective tissue, mature and immature T lymphocytes, dendritic cells, variable numbers of perivascular B-lymphocytes and plasma cells; site of entry of bone marrow stem cells and exit of mature, functional T cells." [MP:0009543] subset: human_reference_atlas subset: pheno_slim synonym: "thymic cortico-medullary boundary" EXACT [MP:0009543] synonym: "thymic corticomedullary boundary" EXACT [MP:0009543] synonym: "thymic corticomedullary junction" EXACT [MP:0009543] synonym: "thymic corticomedullary zone" EXACT [MP:0009543] synonym: "thymus CMZ" EXACT [MP:0009543] synonym: "thymus cortico-medullary boundary" EXACT [MP:0009543] synonym: "thymus corticomedullary junction" EXACT [MP:0009543] synonym: "thymus corticomedullary zone" EXACT [MP:0009543] xref: EMAPA:37974 {source="MA:th"} is_a: BFO:0000002 is_a: UBERON:0007651 ! anatomical junction intersection_of: UBERON:0007651 ! anatomical junction intersection_of: RO:0002131 UBERON:0002123 ! overlaps cortex of thymus intersection_of: RO:0002131 UBERON:0002124 ! overlaps medulla of thymus relationship: BFO:0000050 UBERON:0002125 ! part of thymus lobule relationship: BFO:0000051 CL:0000451 ! has part dendritic cell relationship: BFO:0000051 CL:0000542 ! has part lymphocyte relationship: BFO:0000051 CL:0000881 ! has part perivascular macrophage relationship: BFO:0000051 UBERON:0001980 ! has part arteriole relationship: RO:0002131 UBERON:0002123 ! overlaps cortex of thymus relationship: RO:0002131 UBERON:0002124 ! overlaps medulla of thymus relationship: RO:0002433 UBERON:0002125 ! contributes to morphology of thymus lobule property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0003990 name: spinal cord motor column def: "The subclasses of motor neurons which are organized into longitudinally oriented columns that occupy distinct and, in some cases, discontinuous domains along the rostrocaudal axis of the spinal cord; motor neurons within a single column send their axons to a common peripheral target." [MP:0009685] subset: pheno_slim is_a: UBERON:0016550 ! spinal cord column relationship: RO:0002433 UBERON:0002240 ! contributes to morphology of spinal cord relationship: RO:0002473 CL:0000100 ! composed primarily of motor neuron [Term] id: UBERON:0004001 name: olfactory bulb layer def: "Missing definition for term UBERON:0004001. Please replace it using linked reference." [MP:0009946] subset: pheno_slim synonym: "cytoarchitectural part of olfactory bulb" EXACT [NLXANAT:20090402] xref: EMAPA:37917 {source="MA:th"} xref: NLXANAT:20090402 is_a: UBERON:0011215 ! central nervous system cell part cluster is_a: UBERON:0022303 ! nervous system cell part layer intersection_of: UBERON:0022303 ! nervous system cell part layer intersection_of: BFO:0000050 UBERON:0002264 ! part of olfactory bulb relationship: BFO:0000050 UBERON:0002264 ! part of olfactory bulb relationship: RO:0002433 UBERON:0002264 ! contributes to morphology of olfactory bulb property_value: IAO:0000116 "TODO - check isa parentage" xsd:string property_value: skos:prefLabel "olfactory bulb layer" xsd:string [Term] id: UBERON:0004003 name: cerebellum hemisphere lobule def: "The region of a cerebellar lobule that resides in either of the lateral sections of the cerebellum outside the vermis; in mammals, the vermis portion of the cerebellum has a foliation pattern along the AP axis that is distinct from the lateral cerebellar hemispheres." [MP:0009963] subset: pheno_slim synonym: "cerebellar hemisphere lobule" EXACT [] synonym: "lobule of cerebellar hemisphere" EXACT [FMA:83880] synonym: "lobule of hemisphere of cerebellum" EXACT [FMA:83880] xref: FMA:83880 xref: MA:0002967 xref: NLXANAT:20081201 is_a: UBERON:0004004 ! cerebellum lobule intersection_of: UBERON:0004004 ! cerebellum lobule intersection_of: BFO:0000050 UBERON:0002245 ! part of cerebellar hemisphere relationship: BFO:0000050 UBERON:0002245 ! part of cerebellar hemisphere relationship: RO:0002433 UBERON:0002245 ! contributes to morphology of cerebellar hemisphere property_value: IAO:0000116 "TODO - define as a region overlapping the lobule" xsd:string property_value: skos:prefLabel "cerebellum hemisphere lobule" xsd:string [Term] id: UBERON:0004004 name: cerebellum lobule def: "One of the the ten gyri of the cerebellar cortex." [MP:0009964] subset: pheno_slim synonym: "lobular parts of the cerebellar cortex" EXACT [BIRNLEX:1084] xref: BIRNLEX:1084 xref: MA:0002966 is_a: UBERON:0002749 ! regional part of cerebellar cortex relationship: RO:0002433 UBERON:0002129 ! contributes to morphology of cerebellar cortex property_value: skos:prefLabel "cerebellum lobule" xsd:string [Term] id: UBERON:0004008 name: cerebellar plate def: "The embryonic pseudostratified epithelium of the fourth cerebellar ventricle that eventually forms the vermis and ventral neuroepithelium." [MP:0000856] subset: pheno_slim synonym: "cerebellum plate" EXACT [] synonym: "cerebellum roof plate" RELATED [EHDAA2:0004401] xref: DHBA:12698 xref: EHDAA2:0004401 xref: neuronames:1373 is_a: BFO:0000002 is_a: UBERON:0000490 {source="EHDAA2"} ! unilaminar epithelium is_a: UBERON:0005291 ! embryonic tissue relationship: BFO:0000050 UBERON:0002037 {source="EHDAA2"} ! part of cerebellum relationship: RO:0002202 UBERON:0005568 {source="EHDAA2"} ! develops from rhombomere 1 roof plate property_value: skos:prefLabel "cerebellar plate" xsd:string [Term] id: UBERON:0004015 name: embryonic-extraembryonic boundary def: "The connection between the embryo proper and extraembryonic tissues." [MP:0003890] subset: pheno_slim is_a: BFO:0000004 is_a: UBERON:0000015 ! non-material anatomical boundary intersection_of: UBERON:0000015 ! non-material anatomical boundary intersection_of: RO:0002220 UBERON:0000478 ! adjacent to extraembryonic structure intersection_of: RO:0002220 UBERON:0002050 ! adjacent to embryonic structure relationship: RO:0002220 UBERON:0000478 ! adjacent to extraembryonic structure relationship: RO:0002220 UBERON:0002050 ! adjacent to embryonic structure property_value: skos:prefLabel "embryonic-extraembryonic boundary" xsd:string [Term] id: UBERON:0004016 name: dermatome def: "A transitional population of migrating mesenchymal cells that derive from somites and that will become dermal cells." [AEO:0001017, AEO:JB] subset: pheno_slim synonym: "cutis plate" EXACT [Wikipedia:Cutis_plate] synonym: "dermatomal mesenchyme" EXACT [Wikipedia:Cutis_plate] synonym: "epimere mesoderm" RELATED [] synonym: "mesenchyma dermatomiale" RELATED OMO:0003011 [Wikipedia:Dermatomal_mesenchyme] xref: AAO:0011028 xref: AEO:0001017 xref: EHDAA2_RETIRED:0003428 xref: EHDAA:1719 xref: EHDAA:1725 xref: EHDAA:1731 xref: EHDAA:1737 xref: EMAPA:32838 xref: FMA:295656 xref: NCIT:C61572 xref: UMLS:C0180383 {source="ncithesaurus:Dermatome"} xref: Wikipedia:Dermatome_(embryology) xref: XAO:0000220 is_a: BFO:0000002 is_a: UBERON:0017650 {source="AEO"} ! developing mesenchymal structure relationship: RO:0002202 UBERON:0004290 {source="EHDAA2-abduced"} ! develops from dermomyotome property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/f/f3/Gray64.png" xsd:anyURI property_value: skos:prefLabel "dermatome" xsd:string [Term] id: UBERON:0004021 name: spongiotrophoblast layer def: "The structure of the outer structural layer of the rodent placenta[MP]." [MP:0004255, PMID:19829370] subset: pheno_slim synonym: "spongiotrophoblast" BROAD [] synonym: "spongiotrophoblast layer of placenta" EXACT [] xref: BTO:0005402 xref: EMAPA:31876 is_a: BFO:0000002 is_a: UBERON:0000119 ! cell layer is_a: UBERON:0005156 ! reproductive structure is_a: UBERON:0005292 ! extraembryonic tissue relationship: BFO:0000050 UBERON:0001987 ! part of placenta relationship: RO:0002202 UBERON:0004364 {source="PMID:19829370"} ! develops from ectoplacental cone relationship: RO:0002473 CL:0002499 ! composed primarily of spongiotrophoblast cell [Term] id: UBERON:0004022 name: germinal neuroepithelium def: "The single layer of epithelial cells that lines the early neural tube and develops into the nervous system and into the neural crest cells." [http://www.ncbi.nlm.nih.gov/books/NBK10047, MP:0004261] subset: pheno_slim synonym: "germinal neuroepithelial layer" EXACT [http://orcid.org/0000-0002-6601-2165] synonym: "germinal neuroepithelium" EXACT [NCBIBook:NBK10047] synonym: "original neural tube" EXACT [NCBIBook:NBK10047] is_a: UBERON:0005291 ! embryonic tissue is_a: UBERON:0034706 {source="NCBIBook:NBK10047"} ! proliferating neuroepithelium disjoint_from: UBERON:0006934 ! sensory epithelium relationship: RO:0002007 UBERON:0001049 ! bounding layer of neural tube relationship: RO:0002220 UBERON:0003842 ! adjacent to neural tube lumen property_value: skos:prefLabel "germinal neuroepithelium" xsd:string [Term] id: UBERON:0004023 name: ganglionic eminence def: "The transient proliferative population of neurons that expands exponentially during late prenatal development; it is a continuous germinal zone distinct from the ventricular zone that surrounds the brain ventricles[MP]." [MP:0004274] subset: pheno_slim synonym: "embryonic GE" BROAD OMO:0003000 [] synonym: "embryonic subventricular zone" EXACT [MP:0004274] synonym: "embryonic SVZ" BROAD OMO:0003000 [] synonym: "embryonic/fetal subventricular zone" EXACT [] synonym: "fetal subventricular zone" EXACT [] synonym: "GE" BROAD OMO:0003000 [] synonym: "subependymal layer" EXACT [MP:0004274] synonym: "subventricular zone" BROAD [DHBA:SZ] synonym: "SVZ" BROAD OMO:0003000 [MP:0004274] xref: DHBA:10549 xref: EMAPA:32665 xref: PBA:128012818 xref: Wikipedia:Ganglionic_eminence is_a: UBERON:0002050 ! embryonic structure relationship: BFO:0000050 UBERON:0001016 ! part of nervous system property_value: skos:prefLabel "ganglionic eminence" xsd:string [Term] id: UBERON:0004024 name: medial ganglionic eminence def: "A distinct elevation of a transient proliferating cell mass of the fetal subventricular zone; this mass contributes most of its cells to the neocortex; however, hippocampal neurons, thalamus, septum and olfactory bulb neurons are also partly derived from the MGE." [MP:0004276] subset: pheno_slim synonym: "MGE" BROAD OMO:0003000 [PMID:23375746] xref: DHBA:10550 xref: EMAPA:37471 {source="MA:th"} xref: PBA:128012834 is_a: UBERON:0002050 ! embryonic structure disjoint_from: UBERON:0004025 {source="lexical"} ! lateral ganglionic eminence relationship: BFO:0000050 UBERON:0004023 ! part of ganglionic eminence relationship: RO:0002433 UBERON:0004023 ! contributes to morphology of ganglionic eminence property_value: skos:prefLabel "medial ganglionic eminence" xsd:string [Term] id: UBERON:0004025 name: lateral ganglionic eminence def: "A distinct elevation of a transient proliferating cell mass of the fetal subventricular zone; this mass contributes most of its cells to the striatum; however, neocortex, thalamus, septum and olfactory bulb neurons are also partly derived from the LGE." [MP:0004277] subset: pheno_slim synonym: "LGE" BROAD OMO:0003000 [PMID:23375746] xref: DHBA:10551 xref: EMAPA:37470 {source="MA:th"} xref: PBA:128012822 is_a: UBERON:0002050 ! embryonic structure relationship: BFO:0000050 UBERON:0004023 ! part of ganglionic eminence relationship: RO:0002433 UBERON:0004023 ! contributes to morphology of ganglionic eminence property_value: skos:prefLabel "lateral ganglionic eminence" xsd:string [Term] id: UBERON:0004026 name: caudal ganglionic eminence def: "The caudally located, distinct elevation of a transient proliferating cell mass of the fetal subventricular zone, located adjacent to the lateral ventricle." [MP:0004278] subset: efo_slim subset: pheno_slim synonym: "CGE" BROAD [] xref: DHBA:10552 xref: EFO:0001911 xref: EMAPA:37469 {source="MA:th"} xref: PBA:128012846 is_a: UBERON:0002050 ! embryonic structure relationship: BFO:0000050 UBERON:0004023 ! part of ganglionic eminence relationship: RO:0002433 UBERON:0004023 ! contributes to morphology of ganglionic eminence property_value: skos:prefLabel "caudal ganglionic eminence" xsd:string [Term] id: UBERON:0004027 name: chorionic plate def: "That portion of the chorionic wall in the region of its uterine attachment, which gives rise to chorionic villi; it consists of the mesoderm that lines the chorionic vesicle and, on the maternal side, of the trophoblast that lines the intervillous spaces; in the last half of gestation, the mesodermal connective tissue is largely replaced by fibrinoid material, and the amnionic membrane is adherent to the fetal side of the plate." [http://www.medilexicon.com/medicaldictionary.php?t=69523, MP:0004560] subset: human_reference_atlas subset: pheno_slim xref: BTO:0002879 xref: EMAPA:31872 xref: NCIT:C34123 xref: SCTID:256391000 xref: UMLS:C0230972 {source="ncithesaurus:Chorionic_Plate"} is_a: UBERON:0005156 ! reproductive structure is_a: UBERON:0005292 ! extraembryonic tissue relationship: BFO:0000050 UBERON:0003124 ! part of chorion membrane relationship: BFO:0000050 UBERON:8600038 ! part of placental disc relationship: RO:0002433 UBERON:0003124 ! contributes to morphology of chorion membrane property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/placenta-full-term-female/v1.1/assets/3d-vh-f-placenta-full-term.glb" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0004029 name: canal of Schlemm def: "The vascular structure encircling the anterior chamber of the eye, through which the aqueous humor is returned to the blood circulation." [MP:0005204, Wikipedia:Schlemm's_canal] subset: pheno_slim synonym: "Schlemm's canal" EXACT [] synonym: "scleral sinus" EXACT [FMA:51873] synonym: "scleral venous sinus" EXACT [FMA:51873] synonym: "sinus venosus of sclera" EXACT [FMA:51873] synonym: "sinus venosus sclerae" EXACT OMO:0003011 [Wikipedia:Schlemm's_canal] xref: EMAPA:37456 {source="MA:th"} xref: FMA:51873 xref: NCIT:C32256 xref: SCTID:280605006 xref: UMLS:C0229108 {source="ncithesaurus:Canal_of_Schlemm"} xref: Wikipedia:Schlemm's_canal xref: ZFA:0005829 is_a: UBERON:0003496 ! head blood vessel is_a: UBERON:0009141 ! craniocervical region vein relationship: BFO:0000050 UBERON:0003956 ! part of aqueous drainage system relationship: RO:0002376 UBERON:0003712 {source="FMA/obol"} ! tributary of cavernous sinus [Term] id: UBERON:0004035 name: cortical subplate def: "The transient outer neural tube region that contains the first generated post-mitotic neurons that receive synaptic input from thalamic axons and in turn project axons to the developing cortical plate." [https://github.com/obophenotype/mouse-anatomy-ontology/issues/1, MP:0008440, Wikipedia:Subplate] subset: pheno_slim synonym: "cerebral cortex subplate" EXACT [EMAPA:32833] synonym: "SP" BROAD OMO:0003000 [BRAINSPAN:BRAINSPAN] synonym: "subplate" EXACT [] synonym: "subplate zone" EXACT [DHBA:10522] xref: DHBA:10522 xref: EMAPA:32703 xref: https://upload.wikimedia.org/wikipedia/commons/thumb/a/ac/Corticogenesis_in_a_wild-type_mouse_with_captions_in_english_copy.png/360px-Corticogenesis_in_a_wild-type_mouse_with_captions_in_english_copy.png xref: neuronames:3233 xref: PBA:294021932 xref: Wikipedia:Subplate is_a: BFO:0000002 is_a: UBERON:0014950 ! layer of developing cerebral cortex intersection_of: UBERON:0014950 ! layer of developing cerebral cortex intersection_of: RO:0002220 UBERON:0004040 ! adjacent to cortical intermediate zone intersection_of: RO:0002220 UBERON:0005343 ! adjacent to cortical plate relationship: RO:0002202 UBERON:0034711 ! develops from cortical preplate relationship: RO:0002220 UBERON:0004040 ! adjacent to cortical intermediate zone relationship: RO:0002220 UBERON:0005343 ! adjacent to cortical plate property_value: skos:prefLabel "cortical subplate" xsd:string [Term] id: UBERON:0004040 name: cortical intermediate zone def: "The region of the developing mammalian cortex that extends between the ventricular zone and the cortical plate (CP); normally, the IZ is a region of tangential migration of cells, and at midgestation, the lower part of the IZ develops into the subventricular zone." [MP:0008457] subset: pheno_slim synonym: "cerebral cortex mantle layer" RELATED [EMAPA:17545] synonym: "cerebral cortex mantle zone" RELATED [] synonym: "cortical mantle layer" RELATED [] synonym: "IZ" BROAD OMO:0003000 [BRAINSPAN:BRAINSPAN] xref: EMAPA:17545 xref: EMAPA:32712 is_a: BFO:0000002 is_a: UBERON:0014950 ! layer of developing cerebral cortex relationship: RO:0002162 NCBITaxon:40674 {source="Wikipedia"} ! in taxon Mammalia relationship: RO:0002202 UBERON:0004061 ! develops from neural tube mantle layer property_value: skos:prefLabel "cortical intermediate zone" xsd:string [Term] id: UBERON:0004041 name: spleen primary B follicle def: "The nodules of small undifferentiated B lymphocytes and follicular dendritic cells located in the spleen white pulp." [MP:0008471] subset: human_reference_atlas subset: pheno_slim synonym: "primary spleen B cell follicle" EXACT [CL:tm] xref: EMAPA:37960 {source="MA:th"} xref: FMA:15843 is_a: UBERON:0001249 ! spleen lymphoid follicle is_a: UBERON:0010422 ! primary nodular lymphoid tissue intersection_of: UBERON:0010422 ! primary nodular lymphoid tissue intersection_of: BFO:0000050 UBERON:0002106 ! part of spleen property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0004042 name: spleen secondary B follicle def: "The nodules of antigen-activated, differentiating B cells, follicular dendritic cells, antigen-presenting T cells and macrophages in the spleen white pulp." [MP:0008472] subset: human_reference_atlas subset: pheno_slim synonym: "secondary spleen B cell follicle" EXACT [CL:tm] synonym: "splenic secondary B cell follicle" EXACT [MP:0008472] xref: EMAPA:37961 {source="MA:th"} is_a: UBERON:0001249 ! spleen lymphoid follicle is_a: UBERON:0001745 ! secondary nodular lymphoid tissue intersection_of: UBERON:0001745 ! secondary nodular lymphoid tissue intersection_of: BFO:0000050 UBERON:0002106 ! part of spleen relationship: RO:0002202 UBERON:0004041 {source="CL:tm"} ! develops from spleen primary B follicle property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0004043 name: semicircular canal ampulla def: "The spherical enlargement at the base of each semicircular canal where they connect with the utricle, containing the crista ampullaris which detects movement of the fluid within the canals." [MP:0008488, Wikipedia:Osseous_ampullae] subset: pheno_slim synonym: "ampullae osseae" RELATED OMO:0003011 [Wikipedia:Osseous_ampullae] synonym: "membraneous ampulla of the semicircular duct" RELATED [MP:0008488] synonym: "semicircular duct ampulla" RELATED [MA:0002770] xref: EMAPA:32831 xref: MA:0002770 xref: SCTID:279759001 xref: Wikipedia:Osseous_ampullae is_a: UBERON:0010000 ! multicellular anatomical structure relationship: BFO:0000050 UBERON:0001856 {source="MA"} ! part of semicircular duct property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/6/65/Vestibular_system%27s_semicircular_canal-_a_cross-section.jpg" xsd:anyURI property_value: IAO:0000116 "TODO check duct vs canal. Also check FMA - has many subtypes of semicircular canal such as 'ampulla of anterior semicircular canal'" xsd:string [Term] id: UBERON:0004044 name: anterior visceral endoderm def: "The extraembryonic tissue that is responsible for the proper orientation of the anterior-posterior axis of the embryo and for appropriate patterning of adjacent embryonic tissue." [MP:0008533] subset: pheno_slim synonym: "AVE" RELATED [BTO:0003361] xref: BTO:0003361 xref: EMAPA:36068 is_a: UBERON:0004877 ! visceral endoderm property_value: seeAlso UBERON:0004341 [Term] id: UBERON:0004053 name: external male genitalia def: "The external masculine genital organs." [MP:0009199] comment: TODO: Relabel. Make distinct organ class. See https://github.com/obophenotype/uberon/issues/547 subset: organ_slim subset: pheno_slim synonym: "external male genital organ" EXACT [BTO:0003097] synonym: "male external genitalia" EXACT [FMA:45642] synonym: "organa genitalia masculina externa" RELATED [BTO:0003097] xref: BTO:0003097 xref: EMAPA:30977 xref: FMA:45642 xref: galen:MaleExternalGenitalia xref: SCTID:362264000 is_a: UBERON:0003135 ! male reproductive organ is_a: UBERON:0004176 ! external genitalia intersection_of: UBERON:0004176 ! external genitalia intersection_of: BFO:0000050 UBERON:0000079 ! part of male reproductive system disjoint_from: UBERON:0005056 ! external female genitalia disjoint_from: UBERON:0009196 ! indifferent external genitalia relationship: RO:0002433 UBERON:0000079 ! contributes to morphology of male reproductive system property_value: RO:0002175 NCBITaxon:50557 property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0004054 name: internal male genitalia def: "The internal masculine genital organs, including the testes, epididymides, deferent ducts, seminal vesicles, prostate, ejaculatory ducts, and bulbourethral glands." [MP:0009205] comment: TODO: Relabel. Make distinct organ class. See https://github.com/obophenotype/uberon/issues/547 subset: organ_slim subset: pheno_slim synonym: "internal male genital organ" EXACT [BTO:0003096] synonym: "male internal genitalia" EXACT [FMA:45655] synonym: "organa genitalia masculina interna" RELATED [BTO:0003096] xref: BTO:0003096 xref: FMA:45655 xref: SCTID:310536002 is_a: UBERON:0003135 ! male reproductive organ is_a: UBERON:0004175 ! internal genitalia intersection_of: UBERON:0004175 ! internal genitalia intersection_of: BFO:0000050 UBERON:0000079 ! part of male reproductive system relationship: RO:0002433 UBERON:0000079 ! contributes to morphology of male reproductive system property_value: IAO:0000116 "consider splitting genitalia from genital organ" xsd:string [Term] id: UBERON:0004058 name: biliary ductule def: "One of the fine terminal elements of the bile duct system, leaving the portal canal, and pursuing a course at the periphery of a lobule of the liver[BTO]. the excretory ducts of the liver that connect the interlobular ductules to the right or left hepatic duct[MP]." [BTO:0002840, MP:0009494] subset: human_reference_atlas subset: pheno_slim synonym: "bile capillary" RELATED [BTO:0002840] synonym: "bile ductule" EXACT [BTO:0002840] synonym: "biliary ductule" EXACT [http://www.mondofacto.com/facts/dictionary?ductuli+biliferi] synonym: "biliary ductule" RELATED [BTO:0002840] synonym: "cholangiole" RELATED [BTO:0002840] synonym: "ductuli biliferi" EXACT [http://www.mondofacto.com/facts/dictionary?ductuli+biliferi] synonym: "terminal cholangiole" RELATED [http://orcid.org/0000-0002-6601-2165] xref: BTO:0002840 xref: EMAPA:37440 {source="MA:th"} xref: TAO:0005164 xref: ZFA:0005164 is_a: UBERON:0000025 ! tube relationship: BFO:0000050 UBERON:0002107 ! part of liver relationship: BFO:0000050 UBERON:0002394 {source="BTO"} ! part of bile duct relationship: RO:0002220 UBERON:0001175 ! adjacent to common hepatic duct property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "biliary ductule" xsd:string [Term] id: UBERON:0004059 name: spinal cord medial motor column def: "The subclasses of motor neurons which project their axons to axial muscles that lie close to the vertebral column; motor neurons in the lateral subdivision of the MMC project their axons to body wall muscles." [MP:0009686] subset: pheno_slim is_a: UBERON:0003990 ! spinal cord motor column [Term] id: UBERON:0004060 name: neural tube ventricular layer def: "The layer of undifferentiated, proliferating cells that line the neural tube lumen that is the immediate transformation of the germinal neuroepithelium." [http://www.ncbi.nlm.nih.gov/books/NBK10047, MP:0009689] subset: pheno_slim synonym: "ependymal layer" BROAD [NCBIBook:NBK10047] synonym: "neural tube ependymal layer" EXACT [NCBIBook:NBK10047] synonym: "neural tube ependymal zone" NARROW [MP:0009689] synonym: "neural tube ventricular germinal zone" EXACT [NCBIBook:NBK10047] synonym: "neural tube ventricular zone" EXACT [MP:0009689] xref: EMAPA:17152 xref: EMAPA:35362 xref: EMAPA_RETIRED:16783 xref: MA:0003193 is_a: UBERON:0005291 ! embryonic tissue is_a: UBERON:0010371 ! ecto-epithelium is_a: UBERON:0034706 {source="NCBIBook:NBK10047"} ! proliferating neuroepithelium relationship: BFO:0000050 UBERON:0001049 ! part of neural tube relationship: RO:0002220 UBERON:0003842 ! adjacent to neural tube lumen relationship: RO:0002495 UBERON:0004022 {source="NCBIBook:NBK10047"} ! immediate transformation of germinal neuroepithelium property_value: IAO:0000116 "consider merging with 'ventricular zone'; note that the MA class probably does not belong here, as this is an embryonic structure" xsd:string property_value: skos:prefLabel "neural tube ventricular layer" xsd:string [Term] id: UBERON:0004061 name: neural tube mantle layer def: "The layer of glia and differentiating neurons that forms as a second layer around the germinal neuroepithium; as this develops it comes to lie between the ventricular and marginal layers and includes the basal and alar plates. Develops into neurons and glia forming a gray matter layer." [http://www.ncbi.nlm.nih.gov/books/NBK10047, MP:0009690] subset: pheno_slim synonym: "future brain marginal layer" RELATED [EMAPA:35360] synonym: "neural tube intermediate zone" EXACT [http://www.ncbi.nlm.nih.gov/books/NBK10047, MP:0009690] xref: EMAPA:17148 xref: EMAPA:35360 xref: neuronames:1367 is_a: UBERON:0005291 ! embryonic tissue is_a: UBERON:0034707 {source="NCBIBook:NBK10047"} ! differentiating neuroepithelium relationship: BFO:0000050 UBERON:0001049 ! part of neural tube relationship: RO:0002202 UBERON:0004022 ! develops from germinal neuroepithelium relationship: RO:0002220 UBERON:0004060 ! adjacent to neural tube ventricular layer relationship: RO:0002220 UBERON:0004062 ! adjacent to neural tube marginal layer property_value: skos:prefLabel "neural tube mantle layer" xsd:string [Term] id: UBERON:0004062 name: neural tube marginal layer def: "The outermost layer of the neural tube that consists of axons from the developing mantle layer and will form the white matter." [http://www.ncbi.nlm.nih.gov/books/NBK10047, MP:0009691] subset: pheno_slim synonym: "brain marginal zone" RELATED [] synonym: "neural tube marginal zone" EXACT [MP:0009691] xref: EMAPA:17151 xref: neuronames:1368 is_a: BFO:0000002 is_a: UBERON:0005162 ! multi cell part structure relationship: BFO:0000050 UBERON:0001049 ! part of neural tube relationship: RO:0002202 UBERON:0004061 ! develops from neural tube mantle layer relationship: RO:0002220 UBERON:0004061 ! adjacent to neural tube mantle layer property_value: skos:prefLabel "neural tube marginal layer" xsd:string [Term] id: UBERON:0004063 name: spinal cord alar plate def: "The region of the mantle layer of the neural tube that lies dorsal to the sulcus limitans and contains primarily sensory neurons and interneurons involved in communication of sensory impulses; the alar plate develops into the dorsal horn in the grey matter of the spinal cord." [MP:0009692] subset: pheno_slim synonym: "alar column spinal cord" EXACT [VHOG:0000899] synonym: "spinal cord alar column" EXACT [MP:0009692] synonym: "spinal cord alar lamina" EXACT [MP:0009692] xref: EMAPA:17149 xref: EMAPA:17581 xref: VHOG:0000899 is_a: UBERON:0005882 ! neural tube alar plate intersection_of: UBERON:0005882 ! neural tube alar plate intersection_of: BFO:0000050 UBERON:0006241 ! part of future spinal cord relationship: BFO:0000050 UBERON:0006241 ! part of future spinal cord relationship: RO:0002433 UBERON:0004061 ! contributes to morphology of neural tube mantle layer property_value: IAO:0000116 "TODO - merge with UBERON:0003054 roof plate?" xsd:string property_value: skos:prefLabel "spinal cord alar plate" xsd:string [Term] id: UBERON:0004064 name: neural tube basal plate def: "The region of the mantle layer of the neural tube that lies ventral to the sulcus limitans and contains primarily motor neurons and interneurons." [http://www.ncbi.nlm.nih.gov/books/NBK10047, MP:0009693, Wikipedia:Basal_plate_(neural_tube)] subset: efo_slim subset: pheno_slim synonym: "basal plate" EXACT [] synonym: "basal plate of neural tube" EXACT [Wikipedia:Basal_plate_(neural_tube)] synonym: "motor part of neural tube" RELATED [] synonym: "spinal cord basal plate" NARROW [MP:0009693] synonym: "ventral part of neural tube" RELATED [] xref: AAO:0010561 xref: EFO:0001904 xref: NCIT:C34111 xref: neuronames:1372 xref: UMLS:C1511061 {source="ncithesaurus:Basal_Plate"} xref: Wikipedia:Basal_plate_(neural_tube) is_a: BFO:0000002 is_a: UBERON:0005291 ! embryonic tissue relationship: BFO:0000050 UBERON:0004061 ! part of neural tube mantle layer relationship: BFO:0000051 CL:0000100 ! has part motor neuron relationship: BSPO:0000102 UBERON:0005478 ! sulcus limitans of neural tube relationship: RO:0002256 UBERON:0002328 ! developmentally induced by notochord relationship: RO:0002433 UBERON:0004061 ! contributes to morphology of neural tube mantle layer property_value: skos:prefLabel "neural tube basal plate" xsd:string [Term] id: UBERON:0004066 name: frontonasal prominence def: "The unpaired embryonic prominence that is formed by the tissues surrounding the forebrain vesicle and develops into the forehead and bridge of the nose/snout." [MP:0009901] subset: pheno_slim synonym: "embryonic frontonasal prominence" EXACT [http://orcid.org/0000-0002-6601-2165] synonym: "forebrain prominence" RELATED [MP:0009901] synonym: "frontonasal mass" RELATED [MP:0009901] synonym: "frontonasal process" RELATED [MP:0009901] synonym: "prominentia frontonasalis" RELATED OMO:0003011 [Wikipedia:Frontonasal_prominence] xref: EHDAA2:0000578 xref: EHDAA:4778 xref: EMAPA:16681 xref: FMA:293101 xref: NCIT:C34182 xref: SCTID:361486000 xref: UMLS:C1517321 {source="ncithesaurus:Frontonasal_Prominence"} xref: VHOG:0001319 xref: Wikipedia:Frontonasal_prominence is_a: UBERON:0009292 ! embryonic nasal process relationship: BSPO:0005001 UBERON:0000033 ! head property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/9/98/Gray44.png" xsd:anyURI property_value: skos:prefLabel "frontonasal prominence" xsd:string [Term] id: UBERON:0004067 name: lateral nasal prominence def: "The lateral area of the two branches of a horseshoe-shaped mesenchymal swelling in the future nasal region of the embryo; it separates the olfactory pit from the developing eye and the ala of the nose/snout develops from it." [MP:0009902, Wikipedia:Lateral_nasal_prominence] subset: pheno_slim synonym: "lateral nasal process" EXACT [EHDAA2:0000916] synonym: "lateral nasal swelling" RELATED [https://orcid.org/0000-0002-6601-2165] synonym: "latero-nasal process" EXACT [EMAPA:16805] synonym: "prominentia nasalis lateralis" RELATED OMO:0003011 [Wikipedia:Lateral_nasal_prominence] xref: EHDAA2:0000916 xref: EHDAA:4786 xref: EMAPA:16805 xref: FMA:295864 xref: SCTID:308880000 xref: Wikipedia:Lateral_nasal_prominence is_a: BFO:0000002 is_a: UBERON:0009292 ! embryonic nasal process disjoint_from: UBERON:0004068 {source="lexical"} ! medial nasal prominence relationship: BFO:0000050 UBERON:0004066 {source="EHDAA2"} ! part of frontonasal prominence relationship: RO:0002202 UBERON:0004066 {source="Wikipedia"} ! develops from frontonasal prominence property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/2/2d/Gray48.png" xsd:anyURI property_value: skos:prefLabel "lateral nasal prominence" xsd:string [Term] id: UBERON:0004068 name: medial nasal prominence def: "The central area of the two limbs of a horseshoe-shaped mesenchymal swelling that lie medial to the olfactory placode or pit in the future nasal region of the embryo; it joins with the ipsilateral maxillary prominence in the formation of half of the upper jaw, and the nasal tip and philtrum of the upper lip develop from it." [MP:0009903, Wikipedia:Medial_nasal_prominence] subset: pheno_slim synonym: "medial nasal process" EXACT [EHDAA2:0001076] synonym: "medial nasal swelling" RELATED [https://orcid.org/0000-0002-6601-2165] synonym: "medial-nasal process" EXACT [EMAPA:16808] synonym: "nasomedial prominence" RELATED [https://orcid.org/0000-0002-6601-2165] synonym: "prominentia nasalis medialis" EXACT OMO:0003011 [Wikipedia:Medial_nasal_prominence] xref: EHDAA2:0001076 xref: EHDAA:4792 xref: EMAPA:16808 xref: FMA:295858 xref: SCTID:308877001 xref: VHOG:0000804 xref: Wikipedia:Medial_nasal_prominence is_a: BFO:0000002 is_a: UBERON:0009292 ! embryonic nasal process relationship: BFO:0000050 UBERON:0004066 {source="EHDAA2"} ! part of frontonasal prominence relationship: BSPO:0000126 UBERON:0008816 ! embryonic head relationship: RO:0002202 UBERON:0004066 {source="Wikipedia"} ! develops from frontonasal prominence property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/8/85/Gray45.png" xsd:anyURI property_value: skos:prefLabel "medial nasal prominence" xsd:string [Term] id: UBERON:0004070 name: cerebellum vermis lobule def: "The region of a cerebellar lobule that resides in the central section of the cerebellum between the two hemispheres." [MP:0009957] subset: pheno_slim synonym: "lobule of vermis" EXACT [FMA:278629] xref: EMAPA:35224 xref: FMA:278629 xref: MA:0002968 xref: NLXANAT:20081223 is_a: UBERON:0004004 ! cerebellum lobule intersection_of: UBERON:0004004 ! cerebellum lobule intersection_of: BFO:0000050 UBERON:0004720 ! part of cerebellar vermis relationship: BFO:0000050 UBERON:0004720 ! part of cerebellar vermis relationship: RO:0002433 UBERON:0004720 ! contributes to morphology of cerebellar vermis property_value: IAO:0000116 "TODO - define as a region overlapping" xsd:string property_value: skos:prefLabel "cerebellum vermis lobule" xsd:string [Term] id: UBERON:0004073 name: cerebellum interpositus nucleus def: "The nucleus composed of the globose and emoliform nuclei of the cerebellum; in some mammalian species the globose nucleus is not distinguishable." [MP:0009984] subset: pheno_slim synonym: "interposed nucleus" RELATED [Wikipedia:Interposed_nucleus] synonym: "interposed nucleus of cerebellum" EXACT [] synonym: "interposed nucleus of the cerebellum" EXACT [NeuroNames:1243] synonym: "interposed nucleus of the cerebellum" RELATED [NLXANAT:20081242] synonym: "interpositus" RELATED [Wikipedia:Interposed_nucleus] synonym: "interpositus nucleus" RELATED [Wikipedia:Interposed_nucleus] xref: DHBA:12613 xref: DMBA:16929 xref: EMAPA:37819 {source="MA:th"} xref: HBA:9578 xref: neuronames:1243 xref: NLXANAT:20081242 xref: Wikipedia:Interposed_nucleus is_a: UBERON:0008995 ! nucleus of cerebellar nuclear complex relationship: RO:0002162 NCBITaxon:32524 {source="ISBN:0471888893"} ! in taxon Amniota property_value: RO:0002161 NCBITaxon:8570 {source="ISBN:0471888893"} property_value: skos:prefLabel "cerebellum interpositus nucleus" xsd:string [Term] id: UBERON:0004083 name: cerebellum vermis lobule X def: "Missing definition for term UBERON:0004083. Please replace it using linked reference." [MP:0009997] subset: pheno_slim synonym: "lobule X of cerebellum vermis" EXACT [] synonym: "lobule X of vermis of cerebellum" RELATED [FMA:83882] synonym: "neuraxis nodule" EXACT [UBERON:cjm] synonym: "neuraxis nodulus" EXACT [] synonym: "nodule" BROAD [NeuroNames:681] synonym: "nodulus" BROAD [MA:0001007, neuronames:681] synonym: "nodulus" RELATED [NLXANAT:20081235] synonym: "nodulus (X)" EXACT [ABA:NOD] synonym: "nodulus of cerebellum" EXACT [] synonym: "nodulus of vermis of cerebellum" EXACT [] synonym: "vermic lobule X" EXACT [NLXANAT:20081235] xref: BAMS:NOD xref: BIRNLEX:1165 xref: EMAPA:35234 xref: FMA:83882 xref: HBA:4713 xref: MA:0001007 xref: MBA:968 xref: neuronames:681 xref: NLXANAT:20081235 is_a: UBERON:0004070 {source="MA"} ! cerebellum vermis lobule relationship: BFO:0000050 UBERON:0003012 {source="NIFSTD"} ! part of flocculonodular lobe relationship: RO:0002433 UBERON:0003012 ! contributes to morphology of flocculonodular lobe property_value: skos:prefLabel "cerebellum vermis lobule X" xsd:string [Term] id: UBERON:0004086 name: brain ventricle def: "One of the system of communicating cavities in the brain that are continuous with the central canal of the spinal cord, that like it are derived from the medullary canal of the embryo, that are lined with an epithelial ependyma, and that contain a serous fluid." [https://github.com/obophenotype/uberon/issues/300] subset: efo_slim subset: human_reference_atlas subset: pheno_slim synonym: "brain ventricles" EXACT OMO:0003004 [] synonym: "cerebral ventricle" EXACT [HP:0002118] synonym: "region of ventricular system of brain" EXACT [FMA:78447] xref: BIRNLEX:1356 xref: BTO:0001442 xref: EFO:0001914 xref: EMAPA:32674 xref: FMA:78447 xref: HBA:9418 xref: MA:0000818 xref: MESH:D002552 xref: NCIT:C12356 xref: neuronames:2497 xref: SCTID:180929003 xref: UMLS:C0007799 {source="ncithesaurus:Ventricle_Brain"} is_a: UBERON:0003947 ! brain ventricle/choroid plexus is_a: UBERON:0005358 ! ventricle of nervous system relationship: BFO:0000050 UBERON:0005282 ! part of ventricular system of brain property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "brain ventricle" xsd:string property_value: terms:contributor https://orcid.org/0000-0002-6601-2165 [Term] id: UBERON:0004087 name: vena cava def: "Any of the veins that carries deoxygenated blood from a part of the body into the right atrium of the heart." [http://orcid.org/0000-0002-6601-2165, Wikipedia:Venae_cavae] subset: pheno_slim synonym: "caval vein" RELATED [] synonym: "venae cavae" RELATED OMO:0003004 [Wikipedia:Venae_cavae] xref: AAO:0010215 xref: BTO:0001438 xref: EMAPA:18415 xref: FMA:321896 xref: GAID:547 xref: MA:0000068 xref: MESH:D014684 xref: NCIT:C12817 xref: SCTID:244405007 xref: UMLS:C0042460 {source="ncithesaurus:Vena_Cava"} xref: Wikipedia:Venae_cavae is_a: UBERON:0003479 ! thoracic cavity vein is_a: UBERON:0013768 ! great vessel of heart property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/3/35/Relations_of_the_aorta,_trachea,_esophagus_and_other_heart_structures.png" xsd:anyURI property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/blood-vasculature-female/v1.3/assets/3d-vh-f-blood-vasculature.glb" xsd:anyURI property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/blood-vasculature-male/v1.3/assets/3d-vh-m-blood-vasculature.glb" xsd:anyURI property_value: foaf:depiction "https://upload.wikimedia.org/wikipedia/commons/7/7c/Heart_numlabels.png" xsd:anyURI property_value: skos:prefLabel "vena cava" xsd:string [Term] id: UBERON:0004088 name: orbital region def: "The subdivision of the face that includes the eye (eyeball plus adnexa such as eyelids) and the orbit of the skull and associated parts of the face such as the eyebrows, if present." [http://orcid.org/0000-0002-6601-2165] subset: pheno_slim synonym: "content of orbital part of eye" EXACT [FMA:260119] synonym: "eye region" EXACT [http://orcid.org/0000-0002-6601-2165] synonym: "ocular and peri-ocular region" RELATED [] synonym: "ocular region" RELATED [] synonym: "orbital content" RELATED [FMA:260119] synonym: "orbital part of eye" RELATED [FMA:72951] synonym: "orbital part of face" EXACT [http://orcid.org/0000-0002-6601-2165] xref: FMA:260119 is_a: UBERON:0001444 ! subdivision of head relationship: BFO:0000050 UBERON:0001456 ! part of face property_value: IAO:0000116 "note the FMA class is more narrow though, and is more like eye + muscles + vasculature. The FMA also has FMA:72951 orbital part of eye" xsd:string property_value: skos:prefLabel "orbital region" xsd:string [Term] id: UBERON:0004089 name: midface def: "The middle of the face including the nose and its associated bony structures[MW]." [HP:0000309, http://www.merriam-webster.com/medical/midface] subset: pheno_slim synonym: "lower face" RELATED [] synonym: "midface/lower face" RELATED [] synonym: "snout" RELATED SENSU [MA:0001910] xref: FMA:285406 xref: MA:0001910 is_a: UBERON:0001444 ! subdivision of head relationship: BFO:0000050 UBERON:0001456 ! part of face relationship: RO:0002162 NCBITaxon:89593 ! in taxon Craniata relationship: RO:0002433 UBERON:0001456 ! contributes to morphology of face property_value: IAO:0000116 "this class is currently a union of the snout (e.g. in mouse), the midface and the lower face. Note that in MA, snout includes the whole jaw and should thus be more alike the lower face than the midface, so its placement here is not strictly accurate. In future we might introduce specific classes for each of these, and include the full parthood relationships. if this is done, then care should be taken to preserve inferences such as an abnormality of the lower face being an abnormality of the midface." xsd:string property_value: skos:prefLabel "midface" xsd:string [Term] id: UBERON:0004099 name: joint space of elbow def: "Joint cavity shared by all the joints of the elbow. The elbow joint is a compound joint that actually comprises three separate joints: the joints connecting the upper and lower arm: 1) Articulatio humero-ulnaris and 2) Articulatio humero-radialis as well as the proximal joint connecting the forarm bones: 3) Articulatio radio-ulnaris proximalis. All three share a joint cavity which is highly sinuated/scalloped/coved. Joint spaces of the elbow summarizes the joint cavity shared by all three adjoining joints of the elbow joint." [HP:0003943] subset: pheno_slim synonym: "synovial cavity of elbow joint" EXACT [FMA:38911] xref: FMA:38911 is_a: UBERON:0000464 ! anatomical space intersection_of: UBERON:0000464 ! anatomical space intersection_of: RO:0002572 UBERON:0001490 ! luminal space of elbow joint relationship: RO:0002572 UBERON:0001490 ! luminal space of elbow joint [Term] id: UBERON:0004100 name: renal collecting system def: "The collecting duct system of the kidney consists of a series of tubules and ducts that connect the nephrons to the ureter. It participates in electrolyte and fluid balance through reabsorption and excretion, processes regulated by the hormones aldosterone and antidiuretic hormone." [HP:0004742, Wikipedia:Collecting_duct_system] subset: human_reference_atlas subset: pheno_slim synonym: "collecting duct system" EXACT [Wikipedia:Collecting_duct_system] synonym: "kidney collecting duct system" EXACT [Wikipedia:Collecting_duct_system] synonym: "tubulus renalis colligens" RELATED OMO:0003011 [Wikipedia:Collecting_duct_system] xref: FMA:265239 xref: SCTID:279371005 xref: Wikipedia:Collecting_duct_system is_a: UBERON:0000467 ! anatomical system relationship: BFO:0000050 UBERON:0002113 ! part of kidney property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/0/02/Gray1128.png" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0004103 name: alveolar ridge def: "One of the two jaw ridges either on the roof of the mouth between the upper teeth and the hard palate or on the bottom of the mouth behind the lower teeth[WP]. The alveolar ridges contain the sockets (alveoli) of the teeth[HP]." [HP:0006477, Wikipedia:Alveolar_ridge] subset: pheno_slim synonym: "alveolar body" EXACT [MP:0004189] synonym: "alveolar bone" EXACT [MP:0004189] synonym: "alveolar margin" EXACT [] synonym: "alveolar process" EXACT [] synonym: "margo alveolaris" EXACT OMO:0003011 [] xref: BTO:0001383 xref: EMAPA:35118 xref: FMA:313923 xref: GAID:215 xref: MA:0003119 xref: MESH:D000539 xref: NCIT:C89749 xref: SCTID:245790000 xref: UMLS:C0447411 {source="ncithesaurus:Alveolar_Ridge"} xref: Wikipedia:Alveolar_ridge is_a: UBERON:0005913 ! zone of bone organ relationship: BFO:0000050 UBERON:0001708 ! part of jaw skeleton relationship: RO:0002254 UBERON:0008969 {source="PMID:19767574", source="Wikipedia"} ! has developmental contribution from dental follicle [Term] id: UBERON:0004105 name: subungual region def: "Region beneath a nail or claw." [https://orcid.org/0000-0002-6601-2165] subset: pheno_slim xref: CALOHA:TS-2351 is_a: BFO:0000004 is_a: UBERON:0000477 ! anatomical cluster relationship: BFO:0000050 UBERON:0001705 ! part of nail property_value: IAO:0000116 "consider merging with nailbed" xsd:string [Term] id: UBERON:0004109 name: cortex of humerus def: "The outer or sperficial part of the humerus." [PHENOSCAPE:ad] subset: pheno_slim synonym: "compact bone of humerus" EXACT [FMA:31542] synonym: "cortex of the humerus" EXACT [] synonym: "humerus compact bone" EXACT [] synonym: "humerus cortical bone" EXACT [] xref: FMA:31542 is_a: UBERON:0001439 ! compact bone tissue is_a: UBERON:0004269 ! upper arm connective tissue is_a: UBERON:0005808 ! bone tissue of long bone intersection_of: UBERON:0001439 ! compact bone tissue intersection_of: BFO:0000050 UBERON:0000976 ! part of humerus relationship: BFO:0000050 UBERON:0000976 ! part of humerus [Term] id: UBERON:0004111 name: anatomical conduit def: "Any tube, opening or passage that connects two distinct anatomical spaces." [http://orcid.org/0000-0002-6601-2165] subset: common_anatomy synonym: "foramen" NARROW [EHDAA2:0003080] synonym: "foramina" NARROW OMO:0003004 [https://orcid.org/0000-0002-6601-2165] synonym: "opening" RELATED [] synonym: "ostia" RELATED OMO:0003004 [] synonym: "ostium" RELATED [] xref: AEO:0000080 xref: EHDAA2:0003080 xref: FMA:242873 xref: SCTID:346902003 xref: Wikipedia:Foramen is_a: UBERON:0010000 ! multicellular anatomical structure intersection_of: UBERON:0010000 ! multicellular anatomical structure intersection_of: BFO:0000051 UBERON:0013686 ! has part anatomical conduit space intersection_of: RO:0002570 UBERON:0000061 ! conduit for anatomical structure relationship: BFO:0000051 UBERON:0013686 ! has part anatomical conduit space relationship: RO:0002176 UBERON:0000464 {cardinality="2"} ! connects anatomical space relationship: RO:0002176 UBERON:0000464 ! connects anatomical space relationship: RO:0002570 UBERON:0000061 ! conduit for anatomical structure property_value: RO:0002175 NCBITaxon:33090 property_value: RO:0002175 NCBITaxon:33208 property_value: RO:0002175 NCBITaxon:4751 property_value: skos:prefLabel "anatomical conduit" xsd:string [Term] id: UBERON:0004113 name: muscle of auditory ossicle def: "A muscle of the tympanic cavity that attaches to an auditory ossicle." [http://orcid.org/0000-0002-6601-2165] synonym: "auditory ossicles muscle" EXACT [FMA:49026] synonym: "muscle of auditory ossicles" EXACT [FMA:49026] synonym: "muscle of middle ear" RELATED [] synonym: "muscle of tympanic cavity" EXACT [] synonym: "ossicular muscle" EXACT [FMA:49026] synonym: "tympanic cavity muscle" EXACT [MA:0000256] xref: EMAPA:37776 {source="MA:th"} xref: FMA:49026 xref: MA:0000256 xref: NCIT:C33148 xref: SCTID:244778009 xref: UMLS:C1513769 {source="ncithesaurus:Muscle_of_the_Tympanum"} xref: Wikipedia:Muscles_of_auditory_ossicles is_a: UBERON:0002376 {source="FMA"} ! cranial muscle intersection_of: UBERON:0001630 ! muscle organ intersection_of: RO:0002371 UBERON:0001686 ! attached to auditory ossicle bone relationship: BFO:0000050 UBERON:0001756 ! part of middle ear relationship: RO:0001025 UBERON:0004114 ! located in tympanic cavity relationship: RO:0002371 UBERON:0001686 ! attached to auditory ossicle bone [Term] id: UBERON:0004114 name: tympanic cavity def: "Small cavity surrounding the bones of the middle ear." [Wikipedia:Tympanic_cavity] synonym: "anatomical cavity of middle ear" EXACT [OBOL:automatic] synonym: "cavitas tympani" EXACT OMO:0003011 [Wikipedia:Tympanic_cavity] synonym: "cavitas tympanica" RELATED [BTO:0002098] synonym: "cavity of middle ear" EXACT [OBOL:automatic] synonym: "middle ear cavity" EXACT [OBOL:automatic] synonym: "middle-ear cavity" EXACT [OBOL:automatic] synonym: "tympanum" RELATED [BTO:0002098] xref: BTO:0002098 xref: EHDAA2:0004119 xref: EMAPA:37778 {source="MA:th"} xref: FMA:56461 xref: SCTID:362551002 xref: Wikipedia:Tympanic_cavity is_a: BFO:0000002 is_a: UBERON:0002553 ! anatomical cavity is_a: UBERON:0005082 ! tube lumen is_a: UBERON:0010064 {source="EHDAA2"} ! open anatomical space intersection_of: UBERON:0002553 ! anatomical cavity intersection_of: RO:0002572 UBERON:0001756 ! luminal space of middle ear relationship: RO:0002219 UBERON:0010063 ! surrounded by tympanic cavity epithelium relationship: RO:0002221 UBERON:0001686 ! surrounds auditory ossicle bone relationship: RO:0002285 UBERON:0005625 {source="EHDAA2"} ! developmentally replaces tubotympanic recess lumen relationship: RO:0002572 UBERON:0001756 ! luminal space of middle ear property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/1/19/Gray923.png" xsd:anyURI [Term] id: UBERON:0004115 name: blood vessel of tympanic cavity def: "A blood vessel that is part of a tympanic cavity [Automatically generated definition]." [OBOL:automatic] synonym: "anatomical cavity of middle ear blood vessel" EXACT [OBOL:automatic] synonym: "blood vessel of anatomical cavity of middle ear" EXACT [OBOL:automatic] synonym: "blood vessel of cavity of middle ear" EXACT [OBOL:automatic] synonym: "blood vessel of middle ear anatomical cavity" EXACT [OBOL:automatic] synonym: "blood vessel of middle ear cavity" EXACT [OBOL:automatic] synonym: "cavity of middle ear blood vessel" EXACT [OBOL:automatic] synonym: "middle ear anatomical cavity blood vessel" EXACT [OBOL:automatic] synonym: "middle ear blood vessel" EXACT [] synonym: "middle ear cavity blood vessel" EXACT [OBOL:automatic] synonym: "tympanic cavity blood vessel" EXACT [] xref: EMAPA:37775 {source="MA:th"} xref: MA:0001219 is_a: UBERON:0003496 ! head blood vessel intersection_of: UBERON:0001981 ! blood vessel intersection_of: RO:0001025 UBERON:0004114 ! located in tympanic cavity relationship: BFO:0000050 UBERON:0001756 ! part of middle ear relationship: RO:0001025 UBERON:0004114 ! located in tympanic cavity [Term] id: UBERON:0004116 name: nerve of tympanic cavity def: "A nerve that is part of a tympanic cavity [Automatically generated definition]." [OBOL:automatic] synonym: "anatomical cavity of middle ear nerve" EXACT [OBOL:automatic] synonym: "cavity of middle ear nerve" EXACT [OBOL:automatic] synonym: "middle ear anatomical cavity nerve" EXACT [OBOL:automatic] synonym: "middle ear cavity nerve" EXACT [OBOL:automatic] synonym: "nerve of anatomical cavity of middle ear" EXACT [OBOL:automatic] synonym: "nerve of cavity of middle ear" EXACT [OBOL:automatic] synonym: "nerve of middle ear anatomical cavity" EXACT [OBOL:automatic] synonym: "nerve of middle ear cavity" EXACT [OBOL:automatic] synonym: "tympanic cavity nerve" EXACT [] synonym: "tympanic cavity nerves" EXACT [MA:0001222] xref: EMAPA:37777 {source="MA:th"} xref: MA:0001222 is_a: UBERON:0011779 ! nerve of head region intersection_of: UBERON:0001021 ! nerve intersection_of: RO:0001025 UBERON:0004114 ! located in tympanic cavity relationship: BFO:0000050 UBERON:0001756 ! part of middle ear relationship: RO:0001025 UBERON:0004114 ! located in tympanic cavity [Term] id: UBERON:0004117 name: pharyngeal pouch def: "An internal pocketing of pharyngeal endoderm that contacts a region of ectoderm (a pharyngeal cleft) and interdigitates in the anterior and posterior directions with the pharyngeal arches." [http://orcid.org/0000-0002-6601-2165, PMID:23020903, ZFA:0001106] comment: The pouches are polarized structures. For example, whereas the rostral half of each pouch expresses Bmp-7, the caudal half expresses FGF-8 and the dorsal aspect of each pouch is marked via its expression of Pax-1. each pouch has an individual sense of identity. Shh expression is a prominent early feature of the caudal endoderm of the second arch, and individual pouches mark the anterior limits of expression of Hox genes within the pharyngeal endoderm; Hox-a2 has a rostral boundary at the second pouch, Hox-a3 at the third pouch and Hox-a4 at the most caudal pouch[PMID:16313389] subset: efo_slim subset: pheno_slim subset: vertebrate_core synonym: "branchial pouch" EXACT [Wikipedia:Branchial_pouch] synonym: "pharyngeal pouches" RELATED [VHOG:0001203] synonym: "visceral pouch" EXACT SENSU [] synonym: "visceral pouches" RELATED [VHOG:0001203] xref: AAO:0011113 xref: EFO:0003627 xref: EHDAA:1086 xref: EHDAA:1669 xref: EHDAA:579 xref: EHDAA:617 xref: EMAPA:32752 xref: FMA:293063 xref: NCIT:C34252 xref: SCTID:34674002 xref: TAO:0001106 xref: UMLS:C0231067 {source="ncithesaurus:Pharyngeal_Pouch"} xref: VHOG:0001203 xref: Wikipedia:Pharyngeal_pouch_(embryology) xref: XAO:0000282 xref: ZFA:0001106 is_a: UBERON:0002050 ! embryonic structure is_a: UBERON:0003258 ! endoderm of foregut is_a: UBERON:0005291 ! embryonic tissue relationship: BFO:0000050 UBERON:0008814 ! part of pharyngeal arch system relationship: RO:0002131 UBERON:0002539 ! overlaps pharyngeal arch relationship: RO:0002202 UBERON:0007690 {source="EHDAA2", source="ZFA"} ! develops from early pharyngeal endoderm property_value: skos:prefLabel "pharyngeal pouch" xsd:string [Term] id: UBERON:0004118 name: vasculature of iris def: "A vasculature that is part of a iris [Automatically generated definition]." [OBOL:automatic] subset: pheno_slim synonym: "iris blood vessels" EXACT [ZFA:0005568] synonym: "iris vascular network" EXACT [OBOL:automatic] synonym: "iris vasculature" EXACT [] synonym: "vascular network of iris" EXACT [OBOL:automatic] xref: ZFA:0005568 is_a: UBERON:0002203 ! vasculature of eye intersection_of: UBERON:0002049 ! vasculature intersection_of: BFO:0000050 UBERON:0001769 ! part of iris relationship: BFO:0000050 UBERON:0001769 ! part of iris property_value: skos:prefLabel "vasculature of iris" xsd:string [Term] id: UBERON:0004119 name: endoderm-derived structure def: "An anatomical structure that develops (entirely or partially) from the endoderm." [https://orcid.org/0000-0002-6601-2165] subset: grouping_class is_a: BFO:0000002 is_a: UBERON:0000061 ! anatomical structure intersection_of: UBERON:0000061 ! anatomical structure intersection_of: RO:0002202 UBERON:0000925 ! develops from endoderm relationship: RO:0002202 UBERON:0000925 ! develops from endoderm property_value: skos:prefLabel "endoderm-derived structure" xsd:string [Term] id: UBERON:0004120 name: mesoderm-derived structure def: "An anatomical structure that develops (entirely or partially) from the mesoderm." [https://orcid.org/0000-0002-6601-2165] subset: grouping_class synonym: "mesodermal derivative" EXACT [FBbt:00025998] is_a: BFO:0000002 is_a: UBERON:0000061 ! anatomical structure intersection_of: UBERON:0000061 ! anatomical structure intersection_of: RO:0002202 UBERON:0000926 ! develops from mesoderm relationship: RO:0002202 UBERON:0000926 ! develops from mesoderm property_value: skos:prefLabel "mesoderm-derived structure" xsd:string [Term] id: UBERON:0004121 name: ectoderm-derived structure def: "An anatomical structure that develops (entirely or partially) from the ectoderm." [https://orcid.org/0000-0002-6601-2165] subset: grouping_class synonym: "ectodermal deriviative" EXACT [FBbt:00025990] is_a: BFO:0000002 is_a: UBERON:0000061 ! anatomical structure intersection_of: UBERON:0000061 ! anatomical structure intersection_of: RO:0002202 UBERON:0000924 ! develops from ectoderm relationship: RO:0002202 UBERON:0000924 ! develops from ectoderm property_value: skos:prefLabel "ectoderm-derived structure" xsd:string [Term] id: UBERON:0004122 name: genitourinary system def: "Anatomical system that has as its parts the organs concerned with the production and excretion of urine and those concerned with reproduction." [VHOG:0000286] subset: efo_slim subset: pheno_slim synonym: "genito-urinary system" RELATED [FMA:280610] synonym: "genitourinary tract" RELATED [] synonym: "GU tract" RELATED [] synonym: "UG tract" RELATED [] synonym: "urogenital system" EXACT [] synonym: "urogenital tract" RELATED [BTO:0003091] synonym: "Urogenitalsystem" RELATED [BTO:0003091] xref: AAO:0000624 xref: BILA:0000122 xref: BTO:0003091 xref: EFO:0003864 xref: EHDAA:1013 xref: EMAPA:16367 xref: EV:0100094 xref: FMA:280610 xref: GAID:362 xref: galen:GenitoUrinarySystem xref: MESH:D014566 xref: NCIT:C12810 xref: SCTID:278861008 xref: UMLS:C0042066 {source="ncithesaurus:Genitourinary_System"} xref: VHOG:0000286 xref: XAO:0000140 is_a: BFO:0000002 is_a: UBERON:0000467 ! anatomical system intersection_of: UBERON:0000467 ! anatomical system intersection_of: BFO:0000051 UBERON:0000990 ! has part reproductive system intersection_of: BFO:0000051 UBERON:0001008 ! has part renal system relationship: BFO:0000051 UBERON:0000990 ! has part reproductive system relationship: BFO:0000051 UBERON:0001008 ! has part renal system relationship: RO:0002492 UBERON:0000066 ! existence ends during fully formed stage property_value: skos:prefLabel "genitourinary system" xsd:string [Term] id: UBERON:0004123 name: myocardial layer def: "Any of the layers of the myocardium. Example: compact layer, trabecular layer." [http://orcid.org/0000-0002-6601-2165] subset: non_informative subset: pheno_slim synonym: "layer of myocardium" EXACT [] synonym: "myocardium layer" EXACT [] xref: EMAPA:37475 {source="MA:th"} xref: MA:0000080 is_a: UBERON:0005983 ! heart layer intersection_of: UBERON:0004923 ! organ component layer intersection_of: layer_part_of UBERON:0002349 ! myocardium relationship: layer_part_of UBERON:0002349 ! myocardium property_value: skos:prefLabel "myocardial layer" xsd:string [Term] id: UBERON:0004124 name: myocardium trabecular layer def: "The layer of the myocardium composed of projections of contractile myocytes. The trabecular layer is bounded internally by the endocardium. In zebrafish, unlike the trabeculations of higher vertebrates, both atrial and ventricular trabeculae have more strut-like character, and are more uniform without apparent regional differences[ZFA]." [ZFA:0005059] subset: efo_slim subset: vertebrate_core synonym: "heart muscle trabecula" RELATED [] synonym: "heart muscle trabeculae" RELATED OMO:0003004 [] synonym: "myocardial trabeculae carneae" RELATED OMO:0003004 [] synonym: "myocardial trabecular layer" EXACT [] synonym: "trabecula of heart muscle" RELATED [] synonym: "trabeculae" RELATED [TAO:0005059] synonym: "trabecular layer" EXACT [ZFA:0005059] xref: EFO:0003706 xref: MA:0002866 xref: TAO:0005059 xref: ZFA:0005059 is_a: UBERON:0004123 ! myocardial layer intersection_of: UBERON:0004123 ! myocardial layer intersection_of: RO:0002220 UBERON:0002165 ! adjacent to endocardium intersection_of: RO:0002473 GO:0036194 ! composed primarily of muscle cell projection relationship: RO:0002220 UBERON:0002165 ! adjacent to endocardium relationship: RO:0002473 GO:0036194 ! composed primarily of muscle cell projection property_value: skos:prefLabel "myocardium trabecular layer" xsd:string [Term] id: UBERON:0004126 name: trabecular layer of ventricle def: "A myocardium trabecular layer that is part of a cardiac ventricle." [OBOL:automatic] subset: vertebrate_core synonym: "myocardium of region of ventricle" EXACT [FMA:83511] synonym: "trabecular cardiac ventricle muscle" EXACT [GO:0003222] synonym: "ventricular trabecular myocardium" EXACT [GO:0003222] xref: FMA:83511 xref: TAO:0005060 xref: ZFA:0005060 is_a: UBERON:0004124 ! myocardium trabecular layer intersection_of: UBERON:0004124 ! myocardium trabecular layer intersection_of: BFO:0000050 UBERON:0002082 ! part of cardiac ventricle relationship: BFO:0000050 UBERON:0001083 {source="https://github.com/obophenotype/uberon/wiki/Inferring-part-of-relationships"} ! part of myocardium of ventricle property_value: IAO:0000116 "TODO - check FMA" xsd:string property_value: skos:prefLabel "trabecular layer of ventricle" xsd:string [Term] id: UBERON:0004128 name: optic vesicle def: "The optic vesicle is the evagination of neurectoderm that precedes formation of the optic cup[GO]. Portion of tissue that is comprised of neuroepitheium which has pinched off from the anterior neural keel and will form the optic cup[ZFA]." [GO:0003404, Wikipedia:Optic_vesicles] comment: Genes: Six3, Pax6, Rx1 are expressed together in the tip of the neural plate [ISBN:9780878932504 "Developmental Biology"]. Development notes: During subsequent develop- ment, the optic vesicle invaginates and becomes a two-layered structure with an inner neural retina and outer retinal pigment epithelium. As soon as the developing optic vesicle makes contact with the overlying ectoderm, it induces the ectoderm to thicken and form the lens placode [PMID:16496288] subset: pheno_slim subset: vertebrate_core synonym: "evagination" RELATED [] synonym: "eye vesicle" RELATED [XAO:0000228] synonym: "ocular vesicle" RELATED [VHOG:0000165] synonym: "optic vesicles" RELATED OMO:0003004 [ZFA:0000050] xref: AAO:0011039 xref: EHDAA2:0001320 xref: EMAPA:16540 xref: FMA:293357 xref: NCIT:C34236 xref: SCTID:362864008 xref: TAO:0000050 xref: UMLS:C0231106 {source="ncithesaurus:Optic_Vesicle"} xref: VHOG:0000165 xref: Wikipedia:Optic_vesicles xref: XAO:0000228 xref: ZFA:0000050 is_a: UBERON:0000479 ! tissue is_a: UBERON:0004121 ! ectoderm-derived structure relationship: BFO:0000050 UBERON:0010312 {source="ZFA"} ! part of immature eye relationship: RO:0002202 UBERON:0002346 {source="GO-def"} ! develops from neurectoderm relationship: RO:0002202 UBERON:0003071 {source="ZFA"} ! develops from eye primordium relationship: RO:0002256 UBERON:0004880 ! developmentally induced by chordamesoderm property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/e/e0/Gray863.png" xsd:anyURI property_value: skos:prefLabel "optic vesicle" xsd:string [Term] id: UBERON:0004129 name: growth plate cartilage def: "Cartilage that will provide a scaffold for mineralization of endochondral bones as they elongate or grow." [GO:0003417] synonym: "growth plate" RELATED [] is_a: UBERON:0002418 ! cartilage tissue relationship: BFO:0000050 UBERON:0010363 ! part of endochondral element relationship: RO:0002162 NCBITaxon:7742 ! in taxon Vertebrata relationship: RO:0002221 UBERON:0004763 ! surrounds endochondral bone tissue relationship: site_of GO:0030282 ! bone mineralization [Term] id: UBERON:0004130 name: cerebellar layer def: "A cortical cell layer of the cerebellum. Examples: the granular (inner+outer) layer, molecular layer, Purkinje cell layer, and the ventricular layer of the embryo." [http://orcid.org/0000-0002-6601-2165, ncithesaurus:Cortical_Cell_Layer_of_the_Cerebellum] subset: pheno_slim synonym: "cell layer of cerebellar cortex" EXACT [] synonym: "cytoarchitectural part of the cerebellar cortex" EXACT [BIRNLEX:880] synonym: "gray matter layer of cerebellum" EXACT [FMA:83141] synonym: "layer of cerebellar cortex" EXACT [] synonym: "layer of cerebellum" EXACT [] xref: BIRNLEX:880 xref: EMAPA:35212 xref: FMA:83141 xref: MA:0000201 xref: NCIT:C49137 xref: SCTID:360478008 xref: UMLS:C1707522 {source="ncithesaurus:Cortical_Cell_Layer_of_the_Cerebellum"} is_a: UBERON:0011215 ! central nervous system cell part cluster is_a: UBERON:0016548 ! central nervous system gray matter layer intersection_of: UBERON:0016548 ! central nervous system gray matter layer intersection_of: BFO:0000050 UBERON:0002037 ! part of cerebellum relationship: BFO:0000050 UBERON:0002129 ! part of cerebellar cortex relationship: RO:0002433 UBERON:0002129 ! contributes to morphology of cerebellar cortex property_value: skos:prefLabel "cerebellar layer" xsd:string [Term] id: UBERON:0004133 name: salivatory nucleus def: "Missing definition for term UBERON:0004133. Please replace it using linked reference." [GO:0021751] synonym: "salivary nucleus" EXACT [GO:0021751] is_a: UBERON:0006331 ! brainstem nucleus is_a: UBERON:0009662 ! hindbrain nucleus relationship: BFO:0000050 UBERON:0000988 ! part of pons property_value: skos:prefLabel "salivatory nucleus" xsd:string [Term] id: UBERON:0004134 name: proximal tubule def: "In mammals, the proximal tubule is a nephron tubule that connects Bowman's capsule to the loop of Henle. It has a brush border epithelial morphology[GO]." [GO:0072014] subset: human_reference_atlas synonym: "kidney proximal tubule" EXACT [MA:0002611] synonym: "proximal kidney tubule" EXACT [MESH:A05.810.453.736.560.570] synonym: "renal proximal tubule" EXACT [] xref: BTO:0001498 xref: CALOHA:TS-0509 xref: EMAPA:28281 xref: MA:0002611 xref: MESH:D007687 is_a: UBERON:0006853 ! renal cortex tubule relationship: RO:0002150 UBERON:0001230 {source="GO"} ! continuous with glomerular capsule relationship: RO:0002150 UBERON:0001289 {source="GO"} ! continuous with descending limb of loop of Henle property_value: IAO:0000116 "TODO - ensure definition works across species." xsd:string property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0004135 name: distal tubule def: "The distal tubule is a nephron tubule that consists of the distal convoluted tubule and distal straight tubule segments." [GO:0072017] synonym: "kidney distal tubule" EXACT [MA:0002633] synonym: "renal distal tubule" EXACT [] xref: BTO:0000482 xref: CALOHA:TS-0504 xref: EMAPA:28387 xref: MA:0002633 xref: MESH:D007686 is_a: UBERON:0007685 ! region of nephron tubule [Term] id: UBERON:0004136 name: intermediate tubule def: "The intermediate tubule is a nephron tubule that lies between the proximal and distal tubules." [GO:0072018] synonym: "renal intermediate tubule" EXACT [] synonym: "tubulus attenuatus" EXACT [FMA:17718] xref: FMA:17718 is_a: UBERON:0007685 ! region of nephron tubule relationship: BFO:0000050 UBERON:0001288 {source="FMA"} ! part of loop of Henle property_value: IAO:0000116 "TODO - check for applicability across species" xsd:string [Term] id: UBERON:0004139 name: cardiogenic plate def: "The first recognizable structure derived from the heart field." [GO:0003142] subset: pheno_slim synonym: "cardiac crescent" RELATED [EMAPA:16106] synonym: "cardiogenic crescent" RELATED [GO:0003142] synonym: "heart rudiment" RELATED [] synonym: "myocardial plate" EXACT [EHDAA2:0000215] xref: EHDAA2:0000215 xref: EMAPA:16106 xref: VHOG:0000975 is_a: BFO:0000002 is_a: UBERON:0002050 ! embryonic structure relationship: RO:0002202 UBERON:0003084 ! develops from heart primordium property_value: IAO:0000116 "TODO - check plate vs rudiment vs primordium vs endocardial tube. See XAO" xsd:string property_value: skos:prefLabel "cardiogenic plate" xsd:string [Term] id: UBERON:0004140 name: primary heart field def: "A specific region of the lateral mesoderm that will form the primary beating heart tube. In mammals the primary heart field gives rise to the left ventricle." [GO:0003138, GOC:mtg_heart, GOC:rl] synonym: "FHF" RELATED OMO:0003000 [XAO:0004185] synonym: "first heart field" EXACT [XAO:0004185] synonym: "heart field" RELATED [XAO:0004185] synonym: "PHF" RELATED OMO:0003000 [XAO:0004185] synonym: "primary heart field" EXACT [PMID:17276708, XAO:0004185] xref: XAO:0004185 is_a: UBERON:0002050 ! embryonic structure is_a: UBERON:0005291 ! embryonic tissue is_a: UBERON:0007688 ! anlage relationship: BFO:0000050 UBERON:0003081 {source="GO:0003128"} ! part of lateral plate mesoderm relationship: BFO:0000050 UBERON:0036146 {source="https://orcid.org/0000-0003-3308-6245"} ! part of cardiopharyngeal field property_value: skos:prefLabel "primary heart field" xsd:string [Term] id: UBERON:0004141 name: heart tube def: "An epithelial tube that will give rise to the mature heart." [GO:0003143, GOC:mtg_heart] subset: efo_slim subset: pheno_slim subset: vertebrate_core synonym: "embryonic heart tube" EXACT [GO:0003143] synonym: "endocardial heart tube" EXACT [MP:0012700] synonym: "endocardial tube" EXACT [XAO:0000337] xref: AAO:0010411 xref: EFO:0003526 xref: EMAPA:32685 xref: NCIT:C34161 xref: TAO:0000360 xref: XAO:0000337 xref: ZFA:0000360 is_a: UBERON:0003914 ! epithelial tube is_a: UBERON:0005291 ! embryonic tissue is_a: UBERON:0012275 ! meso-epithelium relationship: RO:0002495 UBERON:0005498 {source="ZFA-modified"} ! immediate transformation of primitive heart tube property_value: skos:prefLabel "heart tube" xsd:string [Term] id: UBERON:0004142 name: outflow tract septum def: "The outflow tract septum is a partition in the outflow tract." [GO:0003148] xref: XAO:0004141 is_a: UBERON:0002099 ! cardiac septum intersection_of: UBERON:0002099 ! cardiac septum intersection_of: BFO:0000050 UBERON:0004145 ! part of outflow tract relationship: BFO:0000050 UBERON:0004145 ! part of outflow tract property_value: skos:prefLabel "outflow tract septum" xsd:string [Term] id: UBERON:0004145 name: outflow tract def: "The outflow tract is the portion of the heart through which blood flows into the arteries." [GO:0003151] subset: pheno_slim synonym: "arterial (outflow) pole" RELATED [PMID:20735616] synonym: "cardiac outflow tract" EXACT [PMID:20735616] synonym: "heart outflow tract" EXACT [] xref: EHDAA2:0001351 xref: EHDAA:464 xref: EHDAA:798 xref: EMAPA:16346 xref: MA:0000100 xref: VHOG:0000670 xref: XAO:0004139 is_a: UBERON:0004111 ! anatomical conduit relationship: BFO:0000050 UBERON:0000948 ! part of heart relationship: channel_for UBERON:0000178 ! blood relationship: channels_from UBERON:0000948 ! heart relationship: channels_into UBERON:0001637 ! artery property_value: skos:prefLabel "outflow tract" xsd:string [Term] id: UBERON:0004146 name: His-Purkinje system def: "The His-Purkinje system receives signals from the AV node and is composed of the fibers that regulate cardiac muscle contraction in the ventricles." [GO:0003164, https://github.com/geneontology/go-ontology/issues/12451] synonym: "His-Purkinji network" EXACT [] synonym: "HPS" EXACT OMO:0003000 [] synonym: "VCS" EXACT [] synonym: "ventricular conduction system" EXACT [] is_a: UBERON:0010131 {source="cjm"} ! conducting tissue of heart is_a: UBERON:0018649 ! cardiac muscle tissue of ventricle relationship: BFO:0000050 UBERON:0002350 {source="GO"} ! part of conducting system of heart relationship: RO:0002162 NCBITaxon:32523 {source="PMID:12626327", source="PMID:21234997", source="github:michaelerice"} ! in taxon Tetrapoda [Term] id: UBERON:0004148 name: cardiac vein def: "Vein of heart that drains the myocardium." [http://orcid.org/0000-0002-6601-2165] subset: pheno_slim synonym: "cardiac vein" EXACT [FMA:12846] synonym: "coronary vein" EXACT [ZFA:0005814] synonym: "coronary vein" RELATED [Wikipedia:Coronary_circulation] synonym: "heart vein" EXACT [OBOL:automatic] synonym: "vein of heart" EXACT [OBOL:automatic] xref: EHDAA2:0004507 xref: EMAPA:37137 {source="MA:th"} xref: FMA:12846 xref: galen:CoronaryVein xref: NCIT:C12878 xref: NCIT:C12882 xref: SCTID:277726009 xref: UMLS:C0226654 {source="ncithesaurus:Cardiac_Vein"} xref: UMLS:C0226737 {source="ncithesaurus:Coronary_Vein"} xref: Wikipedia:Coronary_circulation xref: ZFA:0005814 is_a: UBERON:0003498 ! heart blood vessel is_a: UBERON:0005194 ! thoracic vein is_a: UBERON:0013140 {source="FMA"} ! systemic vein intersection_of: UBERON:0001638 ! vein intersection_of: BFO:0000050 UBERON:0000948 ! part of heart intersection_of: RO:0020102 UBERON:0002349 ! vessel drains blood from myocardium relationship: RO:0020102 UBERON:0002349 ! vessel drains blood from myocardium property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/blood-vasculature-female/v1.3/assets/3d-vh-f-blood-vasculature.glb" xsd:anyURI property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/blood-vasculature-male/v1.3/assets/3d-vh-m-blood-vasculature.glb" xsd:anyURI property_value: skos:prefLabel "cardiac vein" xsd:string [Term] id: UBERON:0004151 name: cardiac chamber def: "A cardiac chamber surrounds an enclosed cavity within the heart." [GO:0003205] comment: generic enough to cover FBbt:00003156 heart chamber but this is a cavity. GO defines it as the cavity. TODO - move subclasses. Note this also includes sinus venosus synonym: "chamber of heart" EXACT [] synonym: "heart chamber" EXACT [] xref: FMA:7095 xref: SCTID:276456008 is_a: UBERON:0000064 ! organ part relationship: BFO:0000050 UBERON:0000948 ! part of heart property_value: skos:prefLabel "cardiac chamber" xsd:string [Term] id: UBERON:0004160 name: proepicardium def: "An embryonic group of progenitor cells that forms from an outpouching of the septum transversum near the venous pole of the heart and gives rise to the epicardium." [GO:0003342, http://en.wiktionary.org/wiki/proepicardium] synonym: "proepicardial cluster" EXACT [ZFA:0005808] synonym: "proepicardial organ" EXACT [ZFIN:ZDB-PUB-080218-16] xref: EMAPA:36025 xref: ZFA:0005808 is_a: UBERON:0003104 ! mesenchyme relationship: BFO:0000050 UBERON:0004161 ! part of septum transversum relationship: BFO:0000050 UBERON:0004535 {source="ZFA"} ! part of cardiovascular system property_value: skos:prefLabel "proepicardium" xsd:string [Term] id: UBERON:0004161 name: septum transversum def: "A thick plate of mesodermal tissue that occupies the space between the thoracic cavity and yolk stalk in the early embryo, forming a transverse partition partially separating the coelomic cavity into thoracic and abdominal portions. It gives rise to the central tendon of the diaphragm[VHOG]." [VHOG:0000019, Wikipedia:Septum_transversum] subset: pheno_slim synonym: "transverse septum" EXACT [https://orcid.org/0000-0002-6601-2165] xref: EHDAA2:0001829 xref: EHDAA:736 xref: EMAPA:16318 xref: FMA:295593 xref: NCIT:C34296 xref: SCTID:308819008 xref: UMLS:C0231004 {source="ncithesaurus:Septum_Transversum"} xref: VHOG:0000019 xref: Wikipedia:Septum_transversum is_a: UBERON:0003104 ! mesenchyme relationship: BFO:0000050 UBERON:0002100 ! part of trunk relationship: RO:0001025 UBERON:0002323 ! located in coelemic cavity lumen property_value: skos:prefLabel "septum transversum" xsd:string [Term] id: UBERON:0004164 name: branchiomeric muscle def: "A jaw muscle that arises from cranial mesenchyme and is innervated by cranial nerves." [ISBN:0073040584] synonym: "branchial head muscle" EXACT [XAO:0004325] synonym: "branchiomeric skeletal muscle" EXACT [GO:0014707] xref: Wikipedia:Branchiomeric_musculature xref: XAO:0004325 is_a: UBERON:0001630 ! muscle organ is_a: UBERON:0004120 ! mesoderm-derived structure relationship: RO:0002005 UBERON:0001785 {source="ISBN:0073040584"} ! innervated by cranial nerve relationship: RO:0002202 UBERON:0010360 {source="PMID:21610022"} ! develops from pharyngeal arch mesenchyme from head mesenchyme relationship: RO:0002473 UBERON:0001134 ! composed primarily of skeletal muscle tissue [Term] id: UBERON:0004175 name: internal genitalia def: "The internal genitalia are the internal sex organs such as the uterine tube, the uterus and the vagina in female mammals, and the testis, seminal vesicle, ejaculatory duct and prostate in male mammals." [GO:0035260] comment: TODO: make a subdivision of reproductive system. Relabel. See https://github.com/obophenotype/uberon/issues/547 subset: human_reference_atlas subset: organ_slim subset: pheno_slim synonym: "internal genitalia" EXACT [] synonym: "internal genitals" EXACT [] synonym: "internal reproductive organ" RELATED [] synonym: "internal sex organ" RELATED [] xref: FMA:45652 is_a: UBERON:0003133 ! reproductive organ property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "internal genitalia" xsd:string [Term] id: UBERON:0004176 name: external genitalia def: "The external genitalia are the outer sex organs, such as the penis or vulva in mammals." [GO:0035261] comment: TODO: make a subdivision of reproductive system. Relabel. See https://github.com/obophenotype/uberon/issues/547 subset: organ_slim subset: pheno_slim synonym: "external genitalia" EXACT [] synonym: "external reproductive organ" RELATED [] synonym: "external sex organ" RELATED [] xref: FMA:45643 xref: SCTID:362207005 is_a: UBERON:0003133 ! reproductive organ property_value: skos:prefLabel "external genitalia" xsd:string [Term] id: UBERON:0004177 name: hemopoietic organ def: "Organ that is part of the hematopoietic system." [GOC:Obol] subset: organ_slim subset: pheno_slim synonym: "haematological system organ" EXACT [OBOL:automatic] synonym: "haemopoietic system organ" EXACT [OBOL:automatic] synonym: "hematopoeitic or lymphoid organ" NARROW [] synonym: "hematopoeitic organ" EXACT [] synonym: "hematopoietic system organ" EXACT [OBOL:automatic] synonym: "lymph organ" NARROW [MA:0000747] synonym: "lymphoid organ" NARROW [BTO:0004605, FMA:7143] synonym: "organ of haematological system" EXACT [OBOL:automatic] synonym: "organ of haemopoietic system" EXACT [OBOL:automatic] synonym: "organ of hematopoietic system" EXACT [OBOL:automatic] synonym: "organ of organa haemopoietica" EXACT [OBOL:automatic] synonym: "organa haemopoietica organ" EXACT [OBOL:automatic] xref: BTO:0004605 xref: EMAPA:37665 {source="MA:th"} xref: FMA:7143 xref: MA:0000747 xref: SCTID:361338006 is_a: UBERON:0000062 ! organ intersection_of: UBERON:0000062 ! organ intersection_of: BFO:0000050 UBERON:0002390 ! part of hematopoietic system relationship: BFO:0000050 UBERON:0002390 ! part of hematopoietic system property_value: IAO:0000116 "consider splitting out lymph organ, compare with lymph node" xsd:string property_value: skos:prefLabel "hemopoietic organ" xsd:string [Term] id: UBERON:0004178 name: aorta smooth muscle tissue def: "The nonstriated, involuntary muscle tissue located in the wall of the aorta." [MGI:csmith, MP:0009865] subset: efo_slim subset: pheno_slim synonym: "aorta non-striated muscle" EXACT [OBOL:automatic] synonym: "aorta smooth muscle" EXACT [OBOL:automatic] synonym: "aortic smooth muscle" EXACT [BTO:0001685] xref: BTO:0001685 xref: CALOHA:TS-0048 xref: EFO:0002775 xref: EMAPA:35135 xref: MA:0000702 xref: NCIT:C49191 xref: UMLS:C1706825 {source="ncithesaurus:Aorta_Smooth_Muscle_Tissue"} is_a: UBERON:0004237 ! blood vessel smooth muscle is_a: UBERON:0004695 ! arterial system smooth muscle intersection_of: UBERON:0001135 ! smooth muscle tissue intersection_of: BFO:0000050 UBERON:0000947 ! part of aorta relationship: BFO:0000050 UBERON:0000947 ! part of aorta property_value: skos:prefLabel "aorta smooth muscle tissue" xsd:string [Term] id: UBERON:0004179 name: prostate glandular acinus def: "A saclike structure of the prostate gland, comprised of at least three cell layers: an innermost layer of secretory columnar luminal epithelium, a middle layer of squamous basal epithelium that also contains neuroendocrine cells, transit amplifying cells, and stem cells, and an outer layer of smooth muscle intermixed with other stromal cells." [GO:0060525, PMID:18977204] subset: human_reference_atlas synonym: "prostatic acinus" EXACT [FMA:66808] synonym: "prostatic follicle" EXACT [FMA:66808] xref: FMA:66808 is_a: BFO:0000002 is_a: UBERON:0005156 ! reproductive structure is_a: UBERON:0009842 {source="FMA"} ! glandular acinus relationship: BFO:0000050 UBERON:0000428 {source="GO"} ! part of prostate epithelium relationship: RO:0002202 UBERON:0009843 {source="PMID:18977204"} ! develops from prostate epithelial cord property_value: IAO:0000116 "the muscle layer is implicitly treated as outside the acinus" xsd:string property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0004180 name: mammary gland fat def: "The mammary fat is an adipose structure in the gland that is invaded by the mammary ducts." [GO:0060611] synonym: "adipose tissue of lactiferous gland" EXACT [OBOL:automatic] synonym: "adipose tissue of mammary gland" EXACT [OBOL:automatic] synonym: "fat tissue of lactiferous gland" EXACT [OBOL:automatic] synonym: "fat tissue of lobe of breast" EXACT [OBOL:automatic] synonym: "fat tissue of lobe of mammary gland" EXACT [OBOL:automatic] synonym: "fat tissue of mammary gland" EXACT [OBOL:automatic] synonym: "fatty tissue of lactiferous gland" EXACT [OBOL:automatic] synonym: "fatty tissue of lobe of breast" EXACT [OBOL:automatic] synonym: "fatty tissue of lobe of mammary gland" EXACT [OBOL:automatic] synonym: "fatty tissue of mammary gland" EXACT [OBOL:automatic] synonym: "lactiferous gland adipose tissue" EXACT [OBOL:automatic] synonym: "lactiferous gland fat tissue" EXACT [OBOL:automatic] synonym: "lactiferous gland fatty tissue" EXACT [OBOL:automatic] synonym: "lobe of breast adipose tissue" EXACT [OBOL:automatic] synonym: "lobe of breast fat tissue" EXACT [OBOL:automatic] synonym: "lobe of breast fatty tissue" EXACT [OBOL:automatic] synonym: "lobe of mammary gland adipose tissue" EXACT [OBOL:automatic] synonym: "lobe of mammary gland fat tissue" EXACT [OBOL:automatic] synonym: "lobe of mammary gland fatty tissue" EXACT [OBOL:automatic] synonym: "mammary gland adipose tissue" EXACT [OBOL:automatic] synonym: "mammary gland fat tissue" EXACT [OBOL:automatic] synonym: "mammary gland fatty tissue" EXACT [OBOL:automatic] xref: EMAPA:35539 xref: MA:0002911 is_a: UBERON:0001013 ! adipose tissue is_a: UBERON:0003584 ! mammary gland connective tissue intersection_of: UBERON:0001013 ! adipose tissue intersection_of: BFO:0000050 UBERON:0001911 ! part of mammary gland [Term] id: UBERON:0004182 name: mammary gland cord def: "The solid cord of epithelial cells that emerges from the mammary bud and grows down from the primary mammary mesenchyme and into a second stromal compartment, the fat pad precursor, beneath the dermis." [MP:0013725] synonym: "lactiferous gland cord" EXACT [] synonym: "mammary cord" EXACT [] synonym: "mammary sprout" RELATED [] is_a: UBERON:0003244 ! epithelium of mammary gland is_a: UBERON:0005154 ! epithelial cord is_a: UBERON:0010371 ! ecto-epithelium is_a: UBERON:0034969 ! epithelial layer of duct intersection_of: UBERON:0005154 ! epithelial cord intersection_of: BFO:0000050 UBERON:0001765 ! part of mammary duct relationship: BFO:0000050 UBERON:0001765 ! part of mammary duct relationship: RO:0002202 UBERON:0005333 ! develops from mammary bud [Term] id: UBERON:0004183 name: placental labyrinth blood vessel def: "The embryonic vessels grow through the layer to come in close contact with the maternal blood supply." [GO:0060716] synonym: "blood vessel of labyrinthine layer" EXACT [OBOL:automatic] synonym: "blood vessel of labyrinthine layer of placenta" EXACT [OBOL:automatic] synonym: "blood vessel of placenta labyrinth" EXACT [OBOL:automatic] synonym: "labyrinthine layer blood vessel" EXACT [GO:0060716] synonym: "labyrinthine layer of placenta blood vessel" EXACT [OBOL:automatic] synonym: "placenta labyrinth blood vessel" EXACT [OBOL:automatic] is_a: UBERON:0022358 ! placenta blood vessel intersection_of: UBERON:0001981 ! blood vessel intersection_of: BFO:0000050 UBERON:0003946 ! part of placenta labyrinth relationship: BFO:0000050 UBERON:0003970 ! part of placental labyrinth vasculature [Term] id: UBERON:0004184 name: prostate gland stroma def: "The prostate gland stroma is made up of the mesenchymal or fibroblast cells of the prostate gland." [GO:0060741] subset: human_reference_atlas synonym: "prostate stroma" EXACT [OBOL:automatic] synonym: "prostatic stroma" EXACT [FMA:45719] synonym: "stroma of glandular part of prostate" NARROW [FMA:74349, OBOL:automatic] synonym: "stroma of prostate" EXACT [OBOL:automatic] synonym: "stroma of prostate gland" EXACT [OBOL:automatic] xref: EMAPA:35714 xref: FMA:45719 xref: MA:0002912 xref: NCIT:C13104 xref: UMLS:C1521760 {source="ncithesaurus:Prostatic_Stroma"} is_a: UBERON:0003891 ! stroma is_a: UBERON:0005156 ! reproductive structure intersection_of: UBERON:0003891 ! stroma intersection_of: BFO:0000050 UBERON:0002367 ! part of prostate gland relationship: BFO:0000050 UBERON:0002367 ! part of prostate gland property_value: IAO:0000116 "TODO - check also FMA Stroma of glandular part of prostate" xsd:string property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0004185 name: endodermal part of digestive tract def: "A portions of the gut that is derived from endoderm." [GO:0061031] synonym: "endodermal gut" EXACT [] synonym: "gut endoderm" EXACT [EMAPA:32930] xref: EMAPA:32930 is_a: UBERON:0004119 ! endoderm-derived structure is_a: UBERON:0004921 ! subdivision of digestive tract intersection_of: UBERON:0004921 ! subdivision of digestive tract intersection_of: BFO:0000050 UBERON:0001555 ! part of digestive tract intersection_of: RO:0002202 UBERON:0000925 ! develops from endoderm property_value: skos:prefLabel "endodermal part of digestive tract" xsd:string [Term] id: UBERON:0004186 name: olfactory bulb mitral cell layer def: "The mitral cell layer is composed of pyramidal neurons whose cell bodies are located between the granule cell layer and the plexiform layer." [GO:0061034] subset: pheno_slim synonym: "mitral cell body layer" EXACT [NLXANAT:100201] synonym: "mitral cell layer" EXACT [BTO:0001108] synonym: "mitral cell layer of the olfactory bulb" RELATED [BAMS:Mi] synonym: "OB mitral cell layer" EXACT [DMBA:OB] synonym: "olfactory bulb main mitral cell body layer" RELATED [NLXANAT:100201] xref: BAMS:Mi xref: BTO:0001108 xref: DHBA:11329 xref: DMBA:15912 xref: EMAPA:35611 xref: MA:0000973 xref: NLXANAT:100201 is_a: UBERON:0004001 ! olfactory bulb layer property_value: skos:prefLabel "olfactory bulb mitral cell layer" xsd:string [Term] id: UBERON:0004188 name: glomerular epithelium def: "The glomerular epithelium is an epithelial tissue that covers the outer surfaces of the glomerulus. The glomerular epithelium consists of both parietal and visceral epithelium. Metanephric glomerular parietal epithelial cells are specialized epithelial cells that form tight junctions as a barrier to protein transport. A metanephric glomerular visceral epithelial cell is a specialized epithelial cell that contains 'feet' that interdigitate with the 'feet' of other glomerular epithelial cells in the metanephros." [GO:0072010] subset: human_reference_atlas synonym: "epithelium of glomerulus" EXACT [] synonym: "epithelium of kidney glomerulus" EXACT [] synonym: "epithelium of renal glomerulus" EXACT [] synonym: "glomerular epithelial cell" RELATED [BTO:0001515] synonym: "kidney glomerular epithelium" EXACT [MA:0002847] xref: BTO:0001515 xref: EMAPA:35458 xref: MA:0002847 is_a: UBERON:0004211 ! nephron epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: BFO:0000050 UBERON:0000074 ! part of renal glomerulus relationship: BFO:0000050 UBERON:0000074 ! part of renal glomerulus property_value: IAO:0000116 "TODO - check - GO says outer, BTO says inner. Make this a superclass" xsd:string property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0004189 name: glomerular endothelium def: "The glomerular endothelium is an epithelial tissue that covers the internal surfaces of the glomerulus." [GO:0072011] synonym: "endothelium of renal glomerulus" EXACT [OBOL:automatic] synonym: "renal glomerulus endothelium" EXACT [OBOL:automatic] xref: BTO:0004631 is_a: UBERON:0004188 ! glomerular epithelium is_a: UBERON:0004852 ! cardiovascular system endothelium intersection_of: UBERON:0001986 ! endothelium intersection_of: BFO:0000050 UBERON:0000074 ! part of renal glomerulus relationship: BFO:0000050 UBERON:0004190 ! part of renal glomerulus vasculature [Term] id: UBERON:0004190 name: renal glomerulus vasculature def: "The glomerulus vasculature is composed of the tubule structures that carry blood or lymph in the glomerulus." [GO:0072012] subset: human_reference_atlas synonym: "glomerulus vasculature" EXACT [OBOL:automatic] synonym: "renal glomerulus vascular network" EXACT [OBOL:automatic] synonym: "renal glomerulus vasculature" EXACT [OBOL:automatic] synonym: "vascular network of renal glomerulus" EXACT [OBOL:automatic] synonym: "vasculature of renal glomerulus" EXACT [OBOL:automatic] is_a: UBERON:0006544 ! kidney vasculature intersection_of: UBERON:0002049 ! vasculature intersection_of: BFO:0000050 UBERON:0000074 ! part of renal glomerulus relationship: BFO:0000050 UBERON:0000074 ! part of renal glomerulus property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0004193 name: loop of Henle ascending limb thin segment def: "A sub-portion of the loop of Henle in the nephron of the kidney that is permeable to ions but not to water." [GO:0072021, Wikipedia:Thin_ascending_limb_of_loop_of_Henle] subset: human_reference_atlas subset: pheno_slim synonym: "ascending limb thin segment of loop of Henle" EXACT [] synonym: "ascending thin limb" EXACT [FMA:17720] synonym: "pars ascendens (tubulus attenuatus)" EXACT [FMA:17720] synonym: "thin ascending limb" EXACT [EMAPA:28328] synonym: "thin ascending limb of loop of Henle" EXACT [] xref: EMAPA:28328 xref: EMAPA:28361 xref: FMA:17720 xref: MA:0001678 xref: Wikipedia:Thin_ascending_limb_of_loop_of_Henle is_a: UBERON:0007685 ! region of nephron tubule relationship: BFO:0000050 UBERON:0003455 ! part of inner renal medulla loop of Henle relationship: BFO:0000050 UBERON:0005164 ! part of ascending limb of loop of Henle relationship: RO:0002433 UBERON:0005164 ! contributes to morphology of ascending limb of loop of Henle property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/0/02/Gray1128.png" xsd:anyURI property_value: IAO:0000116 "check relationship to distal tubule" xsd:string property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0004194 name: long nephron def: "Long nephrons are associated with juxtamedullary glomeruli and extend to the inner medulla." [GO:0072029] synonym: "juxtamedullary nephron" RELATED [GO:0072029, http://sourceforge.net/tracker/?func=detail&aid=3031362&group_id=36855&atid=440764] xref: FMA:272054 xref: NCIT:C32892 xref: UMLS:C1517630 {source="ncithesaurus:Juxtamedullary_Nephron"} is_a: UBERON:0001285 ! nephron [Term] id: UBERON:0004195 name: short nephron def: "Short nephrons are associated with mid-cortical glomeruli, and have no short ascending limb, so the limb is situated in the outer medulla." [GO:0072030] xref: FMA:272051 is_a: UBERON:0001285 ! nephron [Term] id: UBERON:0004196 name: proximal convoluted tubule segment 1 def: "The S1 portion is the initial portion of the proximal convoluted tubule and is responsible for avid reabsorption of water and solutes[GO]." [GO:0072031, http://sourceforge.net/tracker/?func=detail&atid=440764&aid=3298740&group_id=36855] subset: human_reference_atlas synonym: "proximal tubule segment 1" EXACT [MA:0002612] synonym: "S1" BROAD [GO:0072031] synonym: "S1 portion of renal tubule" EXACT [] synonym: "S1 portion of tubule" EXACT [] synonym: "segment 1 of proximal tubule" EXACT [EMAPA:29657] xref: EMAPA:29657 xref: MA:0002612 is_a: UBERON:0006555 ! excretory tube relationship: BFO:0000050 UBERON:0001287 {source="GO"} ! part of proximal convoluted tubule relationship: RO:0002216 GO:0070295 {source="GO"} ! capable of part of renal water absorption property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0004197 name: proximal convoluted tubule segment 2 def: "The S2 portion of the tubule is involved in reabsorption of water and sodium chloride[GO]." [GO:0072032] subset: human_reference_atlas synonym: "proximal tubule segment 2" EXACT [MA:0002613] synonym: "S2" BROAD [GO:0072032] synonym: "S2 portion of renal tubule" EXACT [] synonym: "S2 portion of tubule" EXACT [] synonym: "segment 2 of proximal tubule" EXACT [EMAPA:29659] xref: EMAPA:29659 xref: MA:0002613 is_a: UBERON:0006555 ! excretory tube relationship: BFO:0000050 UBERON:0001287 {source="GO"} ! part of proximal convoluted tubule relationship: RO:0002216 GO:0070295 {source="GO"} ! capable of part of renal water absorption property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0004198 name: comma-shaped body def: "The comma-shaped body is the precursor structure to the S-shaped body that contributes to the morphogenesis of the nephron." [GO:0072049] subset: pheno_slim synonym: "CSB" EXACT OMO:0003000 [] xref: EMAPA:27681 xref: ZFA:0005588 is_a: BFO:0000002 is_a: UBERON:0005423 ! developing anatomical structure relationship: BFO:0000050 UBERON:0010532 {source="cjm"} ! part of primitive nephron relationship: RO:0002202 UBERON:0004209 {source="ZFA"} ! develops from renal vesicle [Term] id: UBERON:0004199 name: S-shaped body def: "The S-shaped body is the successor of the comma-shaped body that contributes to the morphogenesis of the nephron." [GO:0072050] subset: pheno_slim synonym: "SSB" EXACT OMO:0003000 [] synonym: "stage II nephron" EXACT [http://www.gudmap.org/Organ_Summaries/Metanephros/Renal_vesicle.html] xref: EMAPA:27756 xref: ZFA:0005589 is_a: BFO:0000002 is_a: UBERON:0005423 ! developing anatomical structure relationship: BFO:0000050 UBERON:0010532 {source="cjm"} ! part of primitive nephron relationship: RO:0002202 UBERON:0004198 {source="GO"} ! develops from comma-shaped body property_value: IAO:0000116 "TODO" xsd:string [Term] id: UBERON:0004200 name: kidney pyramid def: "Kidney pyramids are the conical arrangements of tubules that constitute the renal medulla in a multi-lobed mammalian kidney; they contain the loops of Henle and the medullary collecting ducts." [GO:0072056, http://anatomy.uams.edu/anatomyhtml/kidney.html] subset: human_reference_atlas subset: pheno_slim synonym: "Malphigian pyramid" RELATED MISSPELLING [BTO:0003926] synonym: "Malpighian pyramid" EXACT [Wikipedia:Renal_pyramids] synonym: "Malpighian pyramid" RELATED [] synonym: "medullary pyramid" RELATED [] synonym: "pyramid" BROAD [GO:0072056] synonym: "pyramid of Malphigi" RELATED MISSPELLING [ncithesaurus:Pyramid_of_Malpighi] synonym: "pyramid of Malpighi" RELATED [UBERON:cjm] synonym: "pyramides renales" RELATED OMO:0003011 [Wikipedia:Renal_pyramids] synonym: "pyramis renalis" RELATED [BTO:0003926] synonym: "renal medullary region" RELATED [FMA:258870] synonym: "renal pyramid" EXACT [Wikipedia:Renal_pyramids] xref: BTO:0003926 xref: FMA:258870 xref: MA:0001654 xref: NCIT:C12886 xref: NCIT:C33436 xref: SCTID:361328001 xref: UMLS:C0227629 {source="ncithesaurus:Renal_Pyramid"} xref: UMLS:C1514613 {source="ncithesaurus:Pyramid_of_Malpighi"} xref: Wikipedia:Renal_pyramids is_a: UBERON:0000064 ! organ part relationship: BFO:0000050 UBERON:0000362 ! part of renal medulla relationship: RO:0002433 UBERON:0000362 ! contributes to morphology of renal medulla property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/kidney-female-left/v1.3/assets/3d-vh-f-kidney-l.glb" xsd:anyURI property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/kidney-female-right/v1.3/assets/3d-vh-f-kidney-r.glb" xsd:anyURI property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/kidney-male-left/v1.3/assets/3d-vh-m-kidney-l.glb" xsd:anyURI property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/kidney-male-right/v1.3/assets/3d-vh-m-kidney-r.glb" xsd:anyURI property_value: foaf:depiction "https://upload.wikimedia.org/wikipedia/commons/7/7e/Kidney_PioM.png" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0004201 name: kidney outer medulla inner stripe def: "The inner stripe is a deep, centrally located portion of the renal outer medulla and is traversed by thick and thin portions of nephron tubules." [GO:0072057] subset: human_reference_atlas subset: pheno_slim synonym: "inner stripe" EXACT [GO:0072057] synonym: "inner stripe of medulla of kidney" EXACT [FMA:76663] synonym: "inner stripe of outer medulla" EXACT [EMAPA:29675] synonym: "inner stripe of renal medulla" EXACT [FMA:76663] synonym: "outer medulla inner stripe" EXACT [MA:0002626] synonym: "stria interna medullae renalis" EXACT OMO:0003011 [FMA:76663, FMA:TA] xref: EMAPA:29675 xref: FMA:76663 xref: MA:0002626 is_a: UBERON:0010000 ! multicellular anatomical structure relationship: BFO:0000050 UBERON:0001293 ! part of outer medulla of kidney relationship: RO:0002433 UBERON:0001293 ! contributes to morphology of outer medulla of kidney property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0004202 name: kidney outer medulla outer stripe def: "The outer stripe is the region of the kidney that lies distal to the line of termination of the straight renal tubules." [GO:0072058] subset: human_reference_atlas subset: pheno_slim synonym: "outer medulla outer stripe" EXACT [MA:0002629] synonym: "outer stripe" EXACT [GO:0072058] synonym: "outer stripe of medulla of kidney" EXACT [FMA:76662] synonym: "outer stripe of outer medulla" EXACT [EMAPA:29663] synonym: "outer stripe of renal medulla" EXACT [FMA:76662] synonym: "stria externa medullae renalis" EXACT OMO:0003011 [FMA:76662, FMA:TA] xref: EMAPA:29663 xref: FMA:76662 xref: MA:0002629 is_a: UBERON:0010000 ! multicellular anatomical structure relationship: BFO:0000050 UBERON:0001293 ! part of outer medulla of kidney relationship: RO:0002433 UBERON:0001293 ! contributes to morphology of outer medulla of kidney property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0004203 name: cortical collecting duct def: "The cortical collecting duct is the portion of the collecting duct that resides in the renal cortex." [GO:0072059] subset: human_reference_atlas synonym: "kidney cortex collecting duct" EXACT [MA:0002600] synonym: "renal cortex collecting duct" RELATED [MA:0002600] xref: BTO:0002643 xref: EMAPA:28130 xref: MA:0002600 is_a: UBERON:0013522 ! subdivision of tube intersection_of: UBERON:0013522 ! subdivision of tube intersection_of: BFO:0000050 UBERON:0001225 ! part of cortex of kidney intersection_of: BFO:0000050 UBERON:0001232 ! part of collecting duct of renal tubule relationship: BFO:0000050 UBERON:0001225 ! part of cortex of kidney relationship: BFO:0000050 UBERON:0001232 ! part of collecting duct of renal tubule property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0004204 name: outer medullary collecting duct def: "The outer medullary collecting duct is the portion of the collecting duct that lies in the renal outer medulla." [GO:0072060] subset: human_reference_atlas synonym: "kidney outer medulla collecting duct" EXACT [MA:0002599] synonym: "outer renal medulla collecting duct" EXACT [MA:0002599] xref: EMAPA:28346 xref: MA:0002599 is_a: UBERON:0001232 ! collecting duct of renal tubule intersection_of: UBERON:0001232 ! collecting duct of renal tubule intersection_of: BFO:0000050 UBERON:0001293 ! part of outer medulla of kidney relationship: BFO:0000050 UBERON:0001293 ! part of outer medulla of kidney property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0004205 name: inner medullary collecting duct def: "The inner medullary collecting duct is the portion of the collecting duct that lies in the renal inner medulla." [GO:0072061] subset: human_reference_atlas synonym: "inner renal medulla collecting duct" EXACT [MA:0002598] synonym: "kidney inner medulla collecting duct" EXACT [MA:0002598] synonym: "papillary collecting duct" RELATED [MA:0002598] xref: BTO:0004544 xref: EMAPA:28370 xref: MA:0002598 is_a: UBERON:0001232 ! collecting duct of renal tubule intersection_of: UBERON:0001232 ! collecting duct of renal tubule intersection_of: BFO:0000050 UBERON:0001294 ! part of inner medulla of kidney relationship: BFO:0000050 UBERON:0001294 ! part of inner medulla of kidney property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0004208 name: nephrogenic mesenchyme def: "Nephrogenic mesenchyme is the tissue made up of loosely connected mesenchymal cells in the nephron." [GO:0072076] comment: The detailed events associated with the differentiation of the nephrogenic mesenchyme are somewhat complex. It has been suggested that each terminal branch of the ureteric bud stimulates the associated cap mesenchyme tissue to form a renal vesicle (the most primitive stage of nephron development: a stage I nephron). This then elongates, becomes a comma-shaped and then an S-shaped body (stage II nephron), and makes contact with and fuses with the distal component of the ureteric bud. The latter then forms the collecting duct. One fold of the S-shaped body gives rise to Bowman's capsule (also termed the glomerular capsule). Soon afterwards, endothelial cells invade to make a capillary knot-like outgrowth, the glomerular tuft, which goes on to form the glomerulus. The inner epithelial layer of the Bowman's capsule (also called the visceral epithelium, or podocyte layer because it consists of podocytes) is closely apposed to the endothelial glomerulus. Together, the Bowman's capsule and the glomerulus comprise the definitive renal corpuscle. The rest of the nephron elongates to form components of the proximal tubule, the loop of Henle and the distal tubule. The distal pole of the developing nephron connects to the ureteric bud that induced it at an early stage of nephron/ collecting duct development, before differentiation of the proximal tubule, the loop of Henle and the distal tubule are complete. This connection allows the excretory products produced by the kidney to be removed and subsequently transferred, via the ureter, into the bladder where they are stored until it is appropriate to empty the bladder. [http://www.gudmap.org/About/Tutorial/DevMUS.html#DMK_Nephron] synonym: "mesenchyme of nephron" EXACT [OBOL:automatic] synonym: "nephron mesenchyme" EXACT [OBOL:automatic] is_a: UBERON:0003104 ! mesenchyme intersection_of: UBERON:0003104 ! mesenchyme intersection_of: RO:0002387 UBERON:0001285 ! has potential to develop into nephron relationship: RO:0002387 UBERON:0001285 ! has potential to develop into nephron [Term] id: UBERON:0004209 name: renal vesicle def: "The renal vesicle is the primordial structure of the nephron epithelium, and is formed by the condensation of mesenchymal cells." [GO:0072077] synonym: "stage I nephron" EXACT [http://www.gudmap.org/Organ_Summaries/Metanephros/Renal_vesicle.html, ZFA:0005586] is_a: BFO:0000002 is_a: UBERON:0007503 {source="EHDAA2"} ! epithelial vesicle relationship: BFO:0000050 UBERON:0010536 ! part of nephron progenitor relationship: RO:0002202 UBERON:0004208 ! develops from nephrogenic mesenchyme relationship: RO:0002256 UBERON:0000084 ! developmentally induced by ureteric bud relationship: RO:0002387 UBERON:0004211 ! has potential to develop into nephron epithelium property_value: IAO:0000116 "note that this class includes both metanephric and mesonephric vesicles - ZFA and EHDAA2 associations are placed with these classes. TODO - make a more specific develops_from relationship - see UBERON:0005107 ! metanephric cap" xsd:string [Term] id: UBERON:0004211 name: nephron epithelium def: "The nephron epithelium is a tissue that covers the surface of a nephron." [GO:0072088] synonym: "epithelial tissue of nephron" EXACT [OBOL:automatic] synonym: "epithelium of nephron" EXACT [OBOL:automatic] synonym: "nephron epithelial tissue" EXACT [OBOL:automatic] is_a: UBERON:0004819 ! kidney epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: BFO:0000050 UBERON:0001285 ! part of nephron relationship: BFO:0000050 UBERON:0001285 ! part of nephron [Term] id: UBERON:0004212 name: glomerular capillary def: "The small branching blood vessels in the kidney glomerulus that receives blood from the kidney afferent arterioles; these capillaries are under high pressure for filtering within the glomerulus." [MGI:csmith, MP:0011320] subset: human_reference_atlas subset: pheno_slim subset: vertebrate_core synonym: "blood capillary of renal glomerulus" EXACT [OBOL:automatic] synonym: "capillary of renal glomerulus" EXACT [OBOL:automatic] synonym: "capillary vessel of renal glomerulus" EXACT [OBOL:automatic] synonym: "glomerular capillaries" RELATED OMO:0003004 [] synonym: "glomerular capillary system" RELATED [MA:0002587] synonym: "renal glomerulus blood capillary" EXACT [OBOL:automatic] synonym: "renal glomerulus capillary" EXACT [OBOL:automatic] synonym: "renal glomerulus capillary vessel" EXACT [OBOL:automatic] xref: EMAPA:28245 xref: FMA:274259 xref: MA:0002587 xref: NCIT:C32684 xref: SCTID:362049007 xref: TAO:0005284 xref: UMLS:C0226356 {source="ncithesaurus:Glomerular_Capillary"} xref: ZFA:0005284 is_a: UBERON:0003527 ! kidney capillary intersection_of: UBERON:0001982 ! capillary intersection_of: BFO:0000050 UBERON:0000074 ! part of renal glomerulus relationship: BFO:0000050 UBERON:0004190 {source="https://github.com/obophenotype/uberon/wiki/Inferring-part-of-relationships"} ! part of renal glomerulus vasculature relationship: RO:0002170 UBERON:0004639 ! connected to renal afferent arteriole relationship: RO:0002433 UBERON:0000074 ! contributes to morphology of renal glomerulus property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0004214 name: upper leg nerve def: "A nerve that is part of a hindlimb stylopod [Automatically generated definition]." [OBOL:automatic] synonym: "hind limb stylopod nerve" EXACT [OBOL:automatic] synonym: "hindlimb stylopod nerve" EXACT [OBOL:automatic] synonym: "lower extremity stylopod nerve" EXACT [OBOL:automatic] synonym: "thigh RELATED" EXACT [OBOL:automatic] xref: EMAPA:37344 {source="MA:th"} xref: MA:0000685 is_a: UBERON:0003431 ! leg nerve intersection_of: UBERON:0001021 ! nerve intersection_of: BFO:0000050 UBERON:0000376 ! part of hindlimb stylopod relationship: BFO:0000050 UBERON:0000376 ! part of hindlimb stylopod [Term] id: UBERON:0004215 name: back nerve def: "A nerve that is part of a back [Automatically generated definition]." [OBOL:automatic] synonym: "nerve of back" EXACT [OBOL:automatic] xref: EMAPA:37268 {source="MA:th"} xref: MA:0000497 is_a: UBERON:0001021 ! nerve intersection_of: UBERON:0001021 ! nerve intersection_of: BFO:0000050 UBERON:0001137 ! part of dorsum relationship: BFO:0000050 UBERON:0001137 ! part of dorsum property_value: skos:prefLabel "back nerve" xsd:string [Term] id: UBERON:0004216 name: lower arm nerve def: "A nerve that is part of a lower arm [Automatically generated definition]." [OBOL:automatic] xref: EMAPA:37338 {source="MA:th"} xref: MA:0000601 is_a: UBERON:0003433 ! arm nerve intersection_of: UBERON:0001021 ! nerve intersection_of: BFO:0000050 UBERON:0002386 ! part of forelimb zeugopod relationship: BFO:0000050 UBERON:0002386 ! part of forelimb zeugopod [Term] id: UBERON:0004217 name: upper arm nerve def: "A nerve that is part of a forelimb stylopod [Automatically generated definition]." [OBOL:automatic] xref: EMAPA:37337 {source="MA:th"} xref: MA:0000607 is_a: UBERON:0003433 ! arm nerve intersection_of: UBERON:0001021 ! nerve intersection_of: BFO:0000050 UBERON:0003822 ! part of forelimb stylopod relationship: BFO:0000050 UBERON:0003822 ! part of forelimb stylopod [Term] id: UBERON:0004218 name: lower leg nerve def: "A nerve that is part of a lower leg [Automatically generated definition]." [OBOL:automatic] xref: EMAPA:37345 {source="MA:th"} xref: MA:0000679 is_a: UBERON:0003431 ! leg nerve intersection_of: UBERON:0001021 ! nerve intersection_of: BFO:0000050 UBERON:0003823 ! part of hindlimb zeugopod relationship: BFO:0000050 UBERON:0003823 ! part of hindlimb zeugopod [Term] id: UBERON:0004219 name: urethra smooth muscle layer def: "A portion of smooth muscle tissue that is part of a urethra [Automatically generated definition]." [OBOL:automatic] synonym: "muscle layer of urethra" EXACT [FMA:76909] synonym: "muscular coat of urethra" EXACT [FMA:76909] synonym: "muscular layer of urethra" EXACT [FMA:76909] synonym: "smooth muscle of urethra" EXACT [OBOL:automatic] synonym: "smooth muscle tissue of urethra" EXACT [OBOL:automatic] synonym: "tunica muscularis urethrae" EXACT OMO:0003011 [FMA:TA] synonym: "urethra smooth muscle tissue" EXACT [OBOL:automatic] synonym: "urethral smooth muscle" RELATED [MA:0001691] xref: EMAPA:36630 xref: FMA:76909 xref: MA:0001691 is_a: UBERON:0001135 ! smooth muscle tissue intersection_of: UBERON:0001135 ! smooth muscle tissue intersection_of: BFO:0000050 UBERON:0000057 ! part of urethra relationship: BFO:0000050 UBERON:0000057 ! part of urethra [Term] id: UBERON:0004220 name: large intestine smooth muscle def: "A portion of smooth muscle tissue that is part of a large intestine [Automatically generated definition]." [OBOL:automatic] synonym: "involuntary muscle of large intestine" EXACT [OBOL:automatic] synonym: "large intestine involuntary muscle" EXACT [OBOL:automatic] synonym: "large intestine non-striated muscle" EXACT [OBOL:automatic] synonym: "large intestine smooth muscle tissue" EXACT [OBOL:automatic] synonym: "non-striated muscle of large intestine" EXACT [OBOL:automatic] synonym: "smooth muscle of large intestine" EXACT [OBOL:automatic] synonym: "smooth muscle tissue of large intestine" EXACT [OBOL:automatic] xref: EMAPA:35469 xref: MA:0001547 is_a: UBERON:0004221 ! intestine smooth muscle intersection_of: UBERON:0001135 ! smooth muscle tissue intersection_of: BFO:0000050 UBERON:0000059 ! part of large intestine relationship: BFO:0000050 UBERON:0001169 {source="MA"} ! part of wall of large intestine relationship: RO:0002131 UBERON:0011198 ! overlaps muscle layer of large intestine property_value: skos:prefLabel "large intestine smooth muscle" xsd:string [Term] id: UBERON:0004221 name: intestine smooth muscle def: "A portion of smooth muscle tissue that is part of a intestine [Automatically generated definition]." [OBOL:automatic] subset: pheno_slim synonym: "bowel involuntary muscle" EXACT [OBOL:automatic] synonym: "bowel non-striated muscle" EXACT [OBOL:automatic] synonym: "bowel smooth muscle" EXACT [OBOL:automatic] synonym: "bowel smooth muscle tissue" EXACT [OBOL:automatic] synonym: "intestinal muscularis" RELATED [EMAPA:35441] synonym: "intestinal smooth muscle" RELATED [BTO:0000643] synonym: "intestine involuntary muscle" EXACT [OBOL:automatic] synonym: "intestine non-striated muscle" EXACT [OBOL:automatic] synonym: "intestine smooth muscle tissue" EXACT [OBOL:automatic] synonym: "involuntary muscle of bowel" EXACT [OBOL:automatic] synonym: "involuntary muscle of intestine" EXACT [OBOL:automatic] synonym: "non-striated muscle of bowel" EXACT [OBOL:automatic] synonym: "non-striated muscle of intestine" EXACT [OBOL:automatic] synonym: "smooth muscle of bowel" EXACT [OBOL:automatic] synonym: "smooth muscle of intestine" EXACT [OBOL:automatic] synonym: "smooth muscle tissue of bowel" EXACT [OBOL:automatic] synonym: "smooth muscle tissue of intestine" EXACT [OBOL:automatic] xref: BTO:0000643 xref: EMAPA:35441 xref: EMAPA:35443 xref: MA:0001539 xref: NCIT:C49243 xref: UMLS:C1708547 {source="ncithesaurus:Intestinal_Smooth_Muscle_Tissue"} is_a: UBERON:0004226 ! gastrointestinal system smooth muscle intersection_of: UBERON:0001135 ! smooth muscle tissue intersection_of: BFO:0000050 UBERON:0000160 ! part of intestine relationship: BFO:0000050 UBERON:0001262 ! part of wall of intestine relationship: RO:0002131 UBERON:0012367 ! overlaps muscle layer of intestine relationship: RO:0002433 UBERON:0000160 ! contributes to morphology of intestine property_value: skos:prefLabel "intestine smooth muscle" xsd:string [Term] id: UBERON:0004222 name: stomach smooth muscle def: "A portion of smooth muscle tissue that is part of a stomach [Automatically generated definition]." [OBOL:automatic] synonym: "gastric muscle" RELATED [BTO:0001818] synonym: "gastric smooth muscle" RELATED [MA:0001627] synonym: "involuntary muscle of stomach" EXACT [OBOL:automatic] synonym: "involuntary muscle of ventriculus" EXACT [OBOL:automatic] synonym: "non-striated muscle of stomach" EXACT [OBOL:automatic] synonym: "non-striated muscle of ventriculus" EXACT [OBOL:automatic] synonym: "smooth muscle of stomach" EXACT [OBOL:automatic] synonym: "smooth muscle of ventriculus" EXACT [OBOL:automatic] synonym: "smooth muscle tissue of stomach" EXACT [OBOL:automatic] synonym: "smooth muscle tissue of ventriculus" EXACT [OBOL:automatic] synonym: "stomach involuntary muscle" EXACT [OBOL:automatic] synonym: "stomach muscle" RELATED [BTO:0001818] synonym: "stomach non-striated muscle" EXACT [OBOL:automatic] synonym: "stomach smooth muscle tissue" EXACT [OBOL:automatic] synonym: "ventriculus involuntary muscle" EXACT [OBOL:automatic] synonym: "ventriculus non-striated muscle" EXACT [OBOL:automatic] synonym: "ventriculus smooth muscle" EXACT [OBOL:automatic] synonym: "ventriculus smooth muscle tissue" EXACT [OBOL:automatic] xref: BTO:0001818 xref: EMAPA:35823 xref: MA:0001627 is_a: UBERON:0004226 ! gastrointestinal system smooth muscle intersection_of: UBERON:0001135 ! smooth muscle tissue intersection_of: BFO:0000050 UBERON:0000945 ! part of stomach relationship: BFO:0000050 UBERON:0001167 ! part of wall of stomach property_value: skos:prefLabel "stomach smooth muscle" xsd:string [Term] id: UBERON:0004223 name: vagina smooth muscle def: "A portion of smooth muscle tissue that is part of a vagina [Automatically generated definition]." [OBOL:automatic] synonym: "involuntary muscle of vagina" EXACT [OBOL:automatic] synonym: "non-striated muscle of vagina" EXACT [OBOL:automatic] synonym: "smooth muscle of vagina" EXACT [OBOL:automatic] synonym: "smooth muscle tissue of vagina" EXACT [OBOL:automatic] synonym: "vagina involuntary muscle" EXACT [OBOL:automatic] synonym: "vagina non-striated muscle" EXACT [OBOL:automatic] synonym: "vagina smooth muscle" RELATED [BTO:0004999] synonym: "vagina smooth muscle tissue" EXACT [OBOL:automatic] synonym: "vaginal smooth muscle" EXACT [BTO:0004999] xref: BTO:0004999 xref: MA:0001733 is_a: UBERON:0001135 ! smooth muscle tissue is_a: UBERON:0005156 ! reproductive structure intersection_of: UBERON:0001135 ! smooth muscle tissue intersection_of: BFO:0000050 UBERON:0000996 ! part of vagina relationship: BFO:0000050 UBERON:0000996 ! part of vagina [Term] id: UBERON:0004224 name: muscular coat of vas deferens def: "A muscular coat that is part of a vas deferens [Automatically generated definition]." [OBOL:automatic] synonym: "muscle layer of deferent duct" EXACT [FMA:19239] synonym: "muscle layer of ductus deferens" EXACT [FMA:19239] synonym: "muscle layer of vas deferens" EXACT [FMA:19239] synonym: "muscular coat of ductus deferens" EXACT [FMA:19239] synonym: "muscular layer of ductus deferens" EXACT [FMA:19239] synonym: "muscularis of vas deferens" EXACT [FMA:19239] synonym: "tunica muscularis (ductus deferens)" EXACT [FMA:19239] synonym: "tunica muscularis ductus deferentis" EXACT OMO:0003011 [FMA:19239, FMA:TA] xref: EMAPA:29270 xref: FMA:19239 xref: MA:0001750 xref: SCTID:299705008 is_a: UBERON:0005156 ! reproductive structure is_a: UBERON:0006660 ! muscular coat is_a: UBERON:0034933 ! layer of smooth muscle tissue intersection_of: UBERON:0006660 ! muscular coat intersection_of: BFO:0000050 UBERON:0001000 ! part of vas deferens relationship: BFO:0000050 UBERON:0001000 ! part of vas deferens property_value: IAO:0000116 "TODO - check MA and FMA classes mean the same thing" xsd:string [Term] id: UBERON:0004225 name: respiratory system smooth muscle def: "A portion of smooth muscle tissue that is part of a respiratory system [Automatically generated definition]." [OBOL:automatic] synonym: "airway smooth muscle" RELATED [BTO:0001660] synonym: "airway smooth muscle cell" RELATED [BTO:0001660] synonym: "respiratory smooth muscle" EXACT [BTO:0001660] synonym: "smooth muscle of respiratory system" EXACT [OBOL:automatic] xref: BTO:0001660 xref: EMAPA:35734 xref: MA:0001830 is_a: UBERON:0001135 ! smooth muscle tissue intersection_of: UBERON:0001135 ! smooth muscle tissue intersection_of: BFO:0000050 UBERON:0001004 ! part of respiratory system relationship: BFO:0000050 UBERON:0001004 ! part of respiratory system property_value: skos:prefLabel "respiratory system smooth muscle" xsd:string [Term] id: UBERON:0004226 name: gastrointestinal system smooth muscle def: "A portion of smooth muscle tissue that is part of a digestive system [Automatically generated definition]." [OBOL:automatic] synonym: "smooth muscle tissue of gastrointestinal system" EXACT [OBOL:automatic] xref: EMAPA:35117 xref: MA:0001523 is_a: UBERON:0001135 ! smooth muscle tissue intersection_of: UBERON:0001135 ! smooth muscle tissue intersection_of: BFO:0000050 UBERON:0005409 ! part of alimentary part of gastrointestinal system relationship: BFO:0000050 UBERON:0005409 ! part of alimentary part of gastrointestinal system property_value: skos:prefLabel "gastrointestinal system smooth muscle" xsd:string [Term] id: UBERON:0004227 name: kidney pelvis smooth muscle def: "The smooth muscle tissue surrounding the urothelium of the kidney pelvis." [MGI:csmith, MP:0011335] subset: pheno_slim synonym: "kidney pelvis smooth muscle" EXACT [EMAPA:28120] synonym: "pelvic smooth muscle" RELATED [EMAPA:28120] synonym: "renal pelvis smooth muscle" EXACT [EMAPA:28120] synonym: "smooth muscle tissue of renal pelvis" EXACT [FMA:262022] xref: EMAPA:28120 xref: FMA:262022 xref: MA:0002631 is_a: UBERON:0001135 ! smooth muscle tissue intersection_of: UBERON:0001135 ! smooth muscle tissue intersection_of: BFO:0000050 UBERON:0001224 ! part of renal pelvis relationship: BFO:0000050 UBERON:0001224 ! part of renal pelvis relationship: RO:0002433 UBERON:0001224 ! contributes to morphology of renal pelvis [Term] id: UBERON:0004228 name: urinary bladder smooth muscle def: "A portion of smooth muscle tissue that is part of a urinary bladder [Automatically generated definition]." [OBOL:automatic] synonym: "bladder involuntary muscle" EXACT [OBOL:automatic] synonym: "bladder non-striated muscle" EXACT [OBOL:automatic] synonym: "bladder smooth muscle" EXACT [OBOL:automatic] synonym: "bladder smooth muscle tissue" EXACT [OBOL:automatic] synonym: "involuntary muscle of bladder" EXACT [OBOL:automatic] synonym: "involuntary muscle of urinary bladder" EXACT [OBOL:automatic] synonym: "non-striated muscle of bladder" EXACT [OBOL:automatic] synonym: "non-striated muscle of urinary bladder" EXACT [OBOL:automatic] synonym: "smooth muscle layer of bladder" RELATED [] synonym: "smooth muscle of bladder" EXACT [OBOL:automatic] synonym: "smooth muscle of urinary bladder" EXACT [OBOL:automatic] synonym: "smooth muscle tissue of bladder" EXACT [OBOL:automatic] synonym: "smooth muscle tissue of urinary bladder" EXACT [OBOL:automatic] synonym: "urinary bladder involuntary muscle" EXACT [OBOL:automatic] synonym: "urinary bladder muscle" EXACT [MA:0001697] synonym: "urinary bladder non-striated muscle" EXACT [OBOL:automatic] synonym: "urinary bladder smooth muscle tissue" EXACT [OBOL:automatic] xref: BTO:0001849 xref: CALOHA:TS-1087 xref: EMAPA:37791 {source="MA:th"} xref: MA:0001697 is_a: UBERON:0001135 ! smooth muscle tissue intersection_of: UBERON:0001135 ! smooth muscle tissue intersection_of: BFO:0000050 UBERON:0001255 ! part of urinary bladder relationship: BFO:0000050 UBERON:0001255 ! part of urinary bladder [Term] id: UBERON:0004229 name: urinary bladder trigone smooth muscle def: "A portion of smooth muscle tissue that is part of a trigone of urinary bladder [Automatically generated definition]." [OBOL:automatic] subset: human_reference_atlas synonym: "deep trigone involuntary muscle" EXACT [OBOL:automatic] synonym: "deep trigone non-striated muscle" EXACT [OBOL:automatic] synonym: "deep trigone smooth muscle" EXACT [OBOL:automatic] synonym: "deep trigone smooth muscle tissue" EXACT [OBOL:automatic] synonym: "involuntary muscle of deep trigone" EXACT [OBOL:automatic] synonym: "involuntary muscle of Lieutaud's trigone" EXACT [OBOL:automatic] synonym: "involuntary muscle of trigone of bladder" EXACT [OBOL:automatic] synonym: "involuntary muscle of trigone of urinary bladder" EXACT [OBOL:automatic] synonym: "involuntary muscle of urinary bladder trigone" EXACT [OBOL:automatic] synonym: "involuntary muscle of vesical trigone" EXACT [OBOL:automatic] synonym: "Lieutaud's trigone involuntary muscle" EXACT [OBOL:automatic] synonym: "Lieutaud's trigone non-striated muscle" EXACT [OBOL:automatic] synonym: "Lieutaud's trigone smooth muscle" EXACT [OBOL:automatic] synonym: "Lieutaud's trigone smooth muscle tissue" EXACT [OBOL:automatic] synonym: "non-striated muscle of deep trigone" EXACT [OBOL:automatic] synonym: "non-striated muscle of Lieutaud's trigone" EXACT [OBOL:automatic] synonym: "non-striated muscle of trigone of bladder" EXACT [OBOL:automatic] synonym: "non-striated muscle of trigone of urinary bladder" EXACT [OBOL:automatic] synonym: "non-striated muscle of urinary bladder trigone" EXACT [OBOL:automatic] synonym: "non-striated muscle of vesical trigone" EXACT [OBOL:automatic] synonym: "smooth muscle of deep trigone" EXACT [OBOL:automatic] synonym: "smooth muscle of Lieutaud's trigone" EXACT [OBOL:automatic] synonym: "smooth muscle of trigone of bladder" EXACT [OBOL:automatic] synonym: "smooth muscle of trigone of urinary bladder" EXACT [OBOL:automatic] synonym: "smooth muscle of urinary bladder trigone" EXACT [OBOL:automatic] synonym: "smooth muscle of vesical trigone" EXACT [OBOL:automatic] synonym: "smooth muscle tissue of deep trigone" EXACT [OBOL:automatic] synonym: "smooth muscle tissue of Lieutaud's trigone" EXACT [OBOL:automatic] synonym: "smooth muscle tissue of trigone of bladder" EXACT [OBOL:automatic] synonym: "smooth muscle tissue of trigone of urinary bladder" EXACT [OBOL:automatic] synonym: "smooth muscle tissue of urinary bladder trigone" EXACT [OBOL:automatic] synonym: "smooth muscle tissue of vesical trigone" EXACT [OBOL:automatic] synonym: "trigone of bladder involuntary muscle" EXACT [OBOL:automatic] synonym: "trigone of bladder non-striated muscle" EXACT [OBOL:automatic] synonym: "trigone of bladder smooth muscle" EXACT [OBOL:automatic] synonym: "trigone of bladder smooth muscle tissue" EXACT [OBOL:automatic] synonym: "trigone of urinary bladder involuntary muscle" EXACT [OBOL:automatic] synonym: "trigone of urinary bladder non-striated muscle" EXACT [OBOL:automatic] synonym: "trigone of urinary bladder smooth muscle" EXACT [OBOL:automatic] synonym: "trigone of urinary bladder smooth muscle tissue" EXACT [OBOL:automatic] synonym: "urinary bladder trigone involuntary muscle" EXACT [OBOL:automatic] synonym: "urinary bladder trigone muscle" EXACT [MA:0001700] synonym: "urinary bladder trigone non-striated muscle" EXACT [OBOL:automatic] synonym: "urinary bladder trigone smooth muscle tissue" EXACT [OBOL:automatic] synonym: "vesical trigone involuntary muscle" EXACT [OBOL:automatic] synonym: "vesical trigone non-striated muscle" EXACT [OBOL:automatic] synonym: "vesical trigone smooth muscle" EXACT [OBOL:automatic] synonym: "vesical trigone smooth muscle tissue" EXACT [OBOL:automatic] xref: EMAPA:28649 xref: MA:0001700 is_a: UBERON:0004228 ! urinary bladder smooth muscle intersection_of: UBERON:0001135 ! smooth muscle tissue intersection_of: BFO:0000050 UBERON:0001257 ! part of trigone of urinary bladder relationship: BFO:0000050 UBERON:0001257 ! part of trigone of urinary bladder property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0004230 name: urinary bladder neck smooth muscle def: "A portion of smooth muscle tissue that is part of a neck of urinary bladder [Automatically generated definition]." [OBOL:automatic] synonym: "bladder neck involuntary muscle" EXACT [OBOL:automatic] synonym: "bladder neck non-striated muscle" EXACT [OBOL:automatic] synonym: "bladder neck smooth muscle" EXACT [OBOL:automatic] synonym: "bladder neck smooth muscle tissue" EXACT [OBOL:automatic] synonym: "involuntary muscle of bladder neck" EXACT [OBOL:automatic] synonym: "involuntary muscle of neck of bladder" EXACT [OBOL:automatic] synonym: "involuntary muscle of neck of urinary bladder" EXACT [OBOL:automatic] synonym: "involuntary muscle of urinary bladder neck" EXACT [OBOL:automatic] synonym: "involuntary muscle of vesical neck" EXACT [OBOL:automatic] synonym: "neck of bladder involuntary muscle" EXACT [OBOL:automatic] synonym: "neck of bladder non-striated muscle" EXACT [OBOL:automatic] synonym: "neck of bladder smooth muscle" EXACT [OBOL:automatic] synonym: "neck of bladder smooth muscle tissue" EXACT [OBOL:automatic] synonym: "neck of urinary bladder involuntary muscle" EXACT [OBOL:automatic] synonym: "neck of urinary bladder non-striated muscle" EXACT [OBOL:automatic] synonym: "neck of urinary bladder smooth muscle" EXACT [OBOL:automatic] synonym: "neck of urinary bladder smooth muscle tissue" EXACT [OBOL:automatic] synonym: "non-striated muscle of bladder neck" EXACT [OBOL:automatic] synonym: "non-striated muscle of neck of bladder" EXACT [OBOL:automatic] synonym: "non-striated muscle of neck of urinary bladder" EXACT [OBOL:automatic] synonym: "non-striated muscle of urinary bladder neck" EXACT [OBOL:automatic] synonym: "non-striated muscle of vesical neck" EXACT [OBOL:automatic] synonym: "smooth muscle of bladder neck" EXACT [OBOL:automatic] synonym: "smooth muscle of neck of bladder" EXACT [OBOL:automatic] synonym: "smooth muscle of neck of urinary bladder" EXACT [OBOL:automatic] synonym: "smooth muscle of urinary bladder neck" EXACT [OBOL:automatic] synonym: "smooth muscle of vesical neck" EXACT [OBOL:automatic] synonym: "smooth muscle tissue of bladder neck" EXACT [OBOL:automatic] synonym: "smooth muscle tissue of neck of bladder" EXACT [OBOL:automatic] synonym: "smooth muscle tissue of neck of urinary bladder" EXACT [OBOL:automatic] synonym: "smooth muscle tissue of urinary bladder neck" EXACT [OBOL:automatic] synonym: "smooth muscle tissue of vesical neck" EXACT [OBOL:automatic] synonym: "trigonal muscle" EXACT [FMA:67990] synonym: "trigonal muscle of urinary bladder" EXACT [FMA:67990] synonym: "urinary bladder neck involuntary muscle" EXACT [OBOL:automatic] synonym: "urinary bladder neck muscle" EXACT [MA:0001699] synonym: "urinary bladder neck non-striated muscle" EXACT [OBOL:automatic] synonym: "urinary bladder neck smooth muscle tissue" EXACT [OBOL:automatic] synonym: "vesical neck involuntary muscle" EXACT [OBOL:automatic] synonym: "vesical neck non-striated muscle" EXACT [OBOL:automatic] synonym: "vesical neck smooth muscle" EXACT [OBOL:automatic] synonym: "vesical neck smooth muscle tissue" EXACT [OBOL:automatic] xref: EMAPA:30123 xref: FMA:67990 xref: MA:0001699 is_a: UBERON:0004228 ! urinary bladder smooth muscle intersection_of: UBERON:0001135 ! smooth muscle tissue intersection_of: BFO:0000050 UBERON:0001258 ! part of neck of urinary bladder relationship: BFO:0000050 UBERON:0001258 ! part of neck of urinary bladder property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/urinary-bladder-female/v1.2/assets/3d-vh-f-urinary-bladder.glb" xsd:anyURI property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/urinary-bladder-male/v1.2/assets/3d-vh-m-urinary-bladder.glb" xsd:anyURI [Term] id: UBERON:0004231 name: anal region smooth muscle def: "A portion of smooth muscle tissue that is part of an anal region [Automatically generated definition]." [OBOL:automatic] synonym: "anal part of perineum involuntary muscle" EXACT [OBOL:automatic] synonym: "anal part of perineum non-striated muscle" EXACT [OBOL:automatic] synonym: "anal part of perineum smooth muscle" EXACT [OBOL:automatic] synonym: "anal part of perineum smooth muscle tissue" EXACT [OBOL:automatic] synonym: "anal region involuntary muscle" EXACT [OBOL:automatic] synonym: "anal region non-striated muscle" EXACT [OBOL:automatic] synonym: "anal region smooth muscle tissue" EXACT [OBOL:automatic] synonym: "anal triangle involuntary muscle" EXACT [OBOL:automatic] synonym: "anal triangle non-striated muscle" EXACT [OBOL:automatic] synonym: "anal triangle smooth muscle" EXACT [OBOL:automatic] synonym: "anal triangle smooth muscle tissue" EXACT [OBOL:automatic] synonym: "involuntary muscle of anal part of perineum" EXACT [OBOL:automatic] synonym: "involuntary muscle of anal region" EXACT [OBOL:automatic] synonym: "involuntary muscle of anal triangle" EXACT [OBOL:automatic] synonym: "non-striated muscle of anal part of perineum" EXACT [OBOL:automatic] synonym: "non-striated muscle of anal region" EXACT [OBOL:automatic] synonym: "non-striated muscle of anal triangle" EXACT [OBOL:automatic] synonym: "smooth muscle of anal part of perineum" EXACT [OBOL:automatic] synonym: "smooth muscle of anal region" EXACT [OBOL:automatic] synonym: "smooth muscle of anal triangle" EXACT [OBOL:automatic] synonym: "smooth muscle tissue of anal part of perineum" EXACT [OBOL:automatic] synonym: "smooth muscle tissue of anal region" EXACT [OBOL:automatic] synonym: "smooth muscle tissue of anal triangle" EXACT [OBOL:automatic] xref: EMAPA:37394 {source="MA:th"} xref: MA:0001532 is_a: UBERON:0001135 ! smooth muscle tissue intersection_of: UBERON:0001135 ! smooth muscle tissue intersection_of: BFO:0000050 UBERON:0001353 ! part of anal region relationship: BFO:0000050 UBERON:0001353 ! part of anal region property_value: skos:prefLabel "anal region smooth muscle" xsd:string [Term] id: UBERON:0004232 name: lymphatic vessel smooth muscle def: "A portion of smooth muscle tissue that is part of a lymphatic vessel [Automatically generated definition]." [OBOL:automatic] subset: pheno_slim synonym: "involuntary muscle of lymph vessel" EXACT [OBOL:automatic] synonym: "involuntary muscle of lymphatic vessel" EXACT [OBOL:automatic] synonym: "lymph vessel involuntary muscle" EXACT [OBOL:automatic] synonym: "lymph vessel non-striated muscle" EXACT [OBOL:automatic] synonym: "lymph vessel smooth muscle" EXACT [OBOL:automatic] synonym: "lymph vessel smooth muscle tissue" EXACT [OBOL:automatic] synonym: "lymphatic vessel involuntary muscle" EXACT [OBOL:automatic] synonym: "lymphatic vessel non-striated muscle" EXACT [OBOL:automatic] synonym: "lymphatic vessel smooth muscle tissue" EXACT [OBOL:automatic] synonym: "non-striated muscle of lymph vessel" EXACT [OBOL:automatic] synonym: "non-striated muscle of lymphatic vessel" EXACT [OBOL:automatic] synonym: "smooth muscle of lymph vessel" EXACT [OBOL:automatic] synonym: "smooth muscle of lymphatic vessel" EXACT [OBOL:automatic] synonym: "smooth muscle tissue of lymph vessel" EXACT [OBOL:automatic] synonym: "smooth muscle tissue of lymphatic vessel" EXACT [OBOL:automatic] xref: EMAPA:36313 xref: FMA:262026 xref: MA:0000751 xref: NCIT:C49260 xref: UMLS:C1708791 {source="ncithesaurus:Lymphatic_Vessel_Smooth_Muscle_Tissue"} is_a: UBERON:0001135 ! smooth muscle tissue intersection_of: UBERON:0001135 ! smooth muscle tissue intersection_of: BFO:0000050 UBERON:0001473 ! part of lymphatic vessel relationship: BFO:0000050 UBERON:0001473 ! part of lymphatic vessel relationship: RO:0002433 UBERON:0001473 ! contributes to morphology of lymphatic vessel [Term] id: UBERON:0004233 name: lower respiratory tract smooth muscle def: "A portion of smooth muscle tissue that is part of a lower respiratory tract [Automatically generated definition]." [OBOL:automatic] synonym: "involuntary muscle of lower respiratory tract" EXACT [OBOL:automatic] synonym: "lower respiratory tract involuntary muscle" EXACT [OBOL:automatic] synonym: "lower respiratory tract non-striated muscle" EXACT [OBOL:automatic] synonym: "lower respiratory tract smooth muscle tissue" EXACT [OBOL:automatic] synonym: "non-striated muscle of lower respiratory tract" EXACT [OBOL:automatic] synonym: "smooth muscle of lower respiratory tract" EXACT [OBOL:automatic] synonym: "smooth muscle tissue of lower respiratory tract" EXACT [OBOL:automatic] xref: EMAPA:35520 xref: MA:0002410 is_a: UBERON:0004225 ! respiratory system smooth muscle intersection_of: UBERON:0001135 ! smooth muscle tissue intersection_of: BFO:0000050 UBERON:0001558 ! part of lower respiratory tract relationship: BFO:0000050 UBERON:0001558 ! part of lower respiratory tract property_value: skos:prefLabel "lower respiratory tract smooth muscle" xsd:string [Term] id: UBERON:0004234 name: iris smooth muscle def: "A portion of smooth muscle tissue that is part of a iris [Automatically generated definition]." [OBOL:automatic] synonym: "involuntary muscle of iris" EXACT [OBOL:automatic] synonym: "iridial smooth muscle" EXACT [http://orcid.org/0000-0002-6601-2165] synonym: "iris involuntary muscle" EXACT [OBOL:automatic] synonym: "iris non-striated muscle" EXACT [OBOL:automatic] synonym: "iris smooth muscle tissue" EXACT [OBOL:automatic] synonym: "non-striated muscle of iris" EXACT [OBOL:automatic] synonym: "smooth muscle of iris" EXACT [OBOL:automatic] synonym: "smooth muscle tissue of iris" EXACT [OBOL:automatic] xref: BTO:0000655 xref: EMAPA:35448 xref: FMA:312338 xref: MA:0001270 is_a: UBERON:0003386 {source="MA"} ! smooth muscle of eye intersection_of: UBERON:0001135 ! smooth muscle tissue intersection_of: BFO:0000050 UBERON:0001769 ! part of iris relationship: BFO:0000050 UBERON:0001606 ! part of muscle of iris property_value: IAO:0000116 "see notes for muscle of iris." xsd:string property_value: skos:prefLabel "iris smooth muscle" xsd:string [Term] id: UBERON:0004235 name: mammary gland smooth muscle def: "A portion of smooth muscle tissue that is part of a mammary gland [Automatically generated definition]." [OBOL:automatic] synonym: "smooth muscle tissue of mammary gland" EXACT [OBOL:automatic] xref: EMAPA:37669 {source="MA:th"} xref: MA:0000795 is_a: UBERON:0001135 ! smooth muscle tissue intersection_of: UBERON:0001135 ! smooth muscle tissue intersection_of: BFO:0000050 UBERON:0001911 ! part of mammary gland relationship: BFO:0000050 UBERON:0001911 ! part of mammary gland [Term] id: UBERON:0004236 name: arteriole smooth muscle def: "A portion of smooth muscle tissue that is part of an arteriole [Automatically generated definition]." [OBOL:automatic] xref: EMAPA:36287 xref: FMA:312251 xref: MA:0000706 is_a: UBERON:0004237 ! blood vessel smooth muscle is_a: UBERON:0004695 ! arterial system smooth muscle intersection_of: UBERON:0001135 ! smooth muscle tissue intersection_of: BFO:0000050 UBERON:0001980 ! part of arteriole relationship: BFO:0000050 UBERON:0001980 ! part of arteriole property_value: skos:prefLabel "arteriole smooth muscle" xsd:string [Term] id: UBERON:0004237 name: blood vessel smooth muscle def: "Smooth muscle found within, and composing the majority of the wall of blood vessels." [Wikipedia:Vascular_smooth_muscle] subset: human_reference_atlas subset: pheno_slim synonym: "blood vessel involuntary muscle" EXACT [OBOL:automatic] synonym: "blood vessel non-striated muscle" EXACT [OBOL:automatic] synonym: "blood vessel smooth muscle tissue" EXACT [OBOL:automatic] synonym: "involuntary muscle of blood vessel" EXACT [OBOL:automatic] synonym: "non-striated muscle of blood vessel" EXACT [OBOL:automatic] synonym: "smooth muscle of blood vessel" EXACT [OBOL:automatic] synonym: "smooth muscle tissue of blood vessel" EXACT [OBOL:automatic] synonym: "vascular smooth muscle" EXACT [ZFA:0005321] synonym: "vascular smooth muscle tissue" EXACT [] xref: BTO:0001431 xref: CALOHA:TS-1107 xref: EMAPA:35177 xref: MA:0000710 xref: MESH:D009131 xref: NCIT:C33853 xref: TAO:0005321 xref: UMLS:C1519956 {source="ncithesaurus:Vascular_Smooth_Muscle_Tissue"} xref: Wikipedia:Vascular_smooth_muscle xref: ZFA:0005321 is_a: UBERON:0001135 ! smooth muscle tissue intersection_of: UBERON:0001135 ! smooth muscle tissue intersection_of: BFO:0000050 UBERON:0001981 ! part of blood vessel relationship: BFO:0000050 UBERON:0001981 ! part of blood vessel property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "blood vessel smooth muscle" xsd:string [Term] id: UBERON:0004238 name: spleen smooth muscle def: "A portion of smooth muscle tissue that is part of a spleen [Automatically generated definition]." [OBOL:automatic] synonym: "involuntary muscle of spleen" EXACT [OBOL:automatic] synonym: "non-striated muscle of spleen" EXACT [OBOL:automatic] synonym: "smooth muscle of spleen" EXACT [OBOL:automatic] synonym: "smooth muscle tissue of spleen" EXACT [OBOL:automatic] synonym: "spleen involuntary muscle" EXACT [OBOL:automatic] synonym: "spleen non-striated muscle" EXACT [OBOL:automatic] synonym: "spleen smooth muscle tissue" EXACT [OBOL:automatic] xref: EMAPA:35807 xref: MA:0000757 is_a: UBERON:0001135 ! smooth muscle tissue intersection_of: UBERON:0001135 ! smooth muscle tissue intersection_of: BFO:0000050 UBERON:0002106 ! part of spleen relationship: BFO:0000050 UBERON:0002106 ! part of spleen property_value: skos:prefLabel "spleen smooth muscle" xsd:string [Term] id: UBERON:0004239 name: small intestine smooth muscle def: "A portion of smooth muscle tissue that is part of a small intestine [Automatically generated definition]." [OBOL:automatic] subset: pheno_slim synonym: "involuntary muscle of small bowel" EXACT [OBOL:automatic] synonym: "involuntary muscle of small intestine" EXACT [OBOL:automatic] synonym: "non-striated muscle of small bowel" EXACT [OBOL:automatic] synonym: "non-striated muscle of small intestine" EXACT [OBOL:automatic] synonym: "small bowel involuntary muscle" EXACT [OBOL:automatic] synonym: "small bowel non-striated muscle" EXACT [OBOL:automatic] synonym: "small bowel smooth muscle" EXACT [OBOL:automatic] synonym: "small bowel smooth muscle tissue" EXACT [OBOL:automatic] synonym: "small intestine involuntary muscle" EXACT [OBOL:automatic] synonym: "small intestine non-striated muscle" EXACT [OBOL:automatic] synonym: "small intestine smooth muscle tissue" EXACT [OBOL:automatic] synonym: "smooth muscle of small bowel" EXACT [OBOL:automatic] synonym: "smooth muscle of small intestine" EXACT [OBOL:automatic] synonym: "smooth muscle tissue of small bowel" EXACT [OBOL:automatic] synonym: "smooth muscle tissue of small intestine" EXACT [OBOL:automatic] xref: EMAPA:35783 xref: MA:0001559 is_a: UBERON:0004221 ! intestine smooth muscle intersection_of: UBERON:0001135 ! smooth muscle tissue intersection_of: BFO:0000050 UBERON:0002108 ! part of small intestine relationship: BFO:0000050 UBERON:0001168 ! part of wall of small intestine relationship: RO:0002131 UBERON:0011201 ! overlaps muscle layer of small intestine property_value: skos:prefLabel "small intestine smooth muscle" xsd:string [Term] id: UBERON:0004240 name: gallbladder smooth muscle def: "A portion of smooth muscle tissue that is part of a gallbladder [Automatically generated definition]." [OBOL:automatic] synonym: "biliary smooth muscle" RELATED [MA:0001635] synonym: "gall bladder involuntary muscle" EXACT [OBOL:automatic] synonym: "gall bladder non-striated muscle" EXACT [OBOL:automatic] synonym: "gall bladder smooth muscle" EXACT [OBOL:automatic] synonym: "gall bladder smooth muscle tissue" EXACT [OBOL:automatic] synonym: "gallbladder involuntary muscle" EXACT [OBOL:automatic] synonym: "gallbladder non-striated muscle" EXACT [OBOL:automatic] synonym: "gallbladder smooth muscle tissue" EXACT [] synonym: "involuntary muscle of gall bladder" EXACT [OBOL:automatic] synonym: "involuntary muscle of gallbladder" EXACT [OBOL:automatic] synonym: "non-striated muscle of gall bladder" EXACT [OBOL:automatic] synonym: "non-striated muscle of gallbladder" EXACT [OBOL:automatic] synonym: "smooth muscle of gall bladder" EXACT [OBOL:automatic] synonym: "smooth muscle of gallbladder" EXACT [OBOL:automatic] synonym: "smooth muscle tissue of gall bladder" EXACT [OBOL:automatic] synonym: "smooth muscle tissue of gallbladder" EXACT [OBOL:automatic] xref: EMAPA:35373 xref: MA:0001635 xref: NCIT:C49483 xref: UMLS:C1708179 {source="ncithesaurus:Gallbladder_Smooth_Muscle_Tissue"} is_a: UBERON:0001135 ! smooth muscle tissue intersection_of: UBERON:0001135 ! smooth muscle tissue intersection_of: BFO:0000050 UBERON:0002110 ! part of gallbladder relationship: BFO:0000050 UBERON:0002110 ! part of gallbladder property_value: skos:prefLabel "gallbladder smooth muscle" xsd:string [Term] id: UBERON:0004242 name: bronchus smooth muscle def: "A portion of smooth muscle tissue that is part of a bronchus [Automatically generated definition]." [OBOL:automatic] subset: human_reference_atlas synonym: "bronchi involuntary muscle" EXACT [OBOL:automatic] synonym: "bronchi non-striated muscle" EXACT [OBOL:automatic] synonym: "bronchi smooth muscle" EXACT [OBOL:automatic] synonym: "bronchi smooth muscle tissue" EXACT [OBOL:automatic] synonym: "bronchial smooth muscle" RELATED [EMAPA:35195] synonym: "bronchial trunk involuntary muscle" EXACT [OBOL:automatic] synonym: "bronchial trunk non-striated muscle" EXACT [OBOL:automatic] synonym: "bronchial trunk smooth muscle" EXACT [OBOL:automatic] synonym: "bronchial trunk smooth muscle tissue" EXACT [OBOL:automatic] synonym: "bronchus involuntary muscle" EXACT [OBOL:automatic] synonym: "bronchus non-striated muscle" EXACT [OBOL:automatic] synonym: "bronchus smooth muscle tissue" EXACT [OBOL:automatic] synonym: "involuntary muscle of bronchi" EXACT [OBOL:automatic] synonym: "involuntary muscle of bronchial trunk" EXACT [OBOL:automatic] synonym: "involuntary muscle of bronchus" EXACT [OBOL:automatic] synonym: "non-striated muscle of bronchi" EXACT [OBOL:automatic] synonym: "non-striated muscle of bronchial trunk" EXACT [OBOL:automatic] synonym: "non-striated muscle of bronchus" EXACT [OBOL:automatic] synonym: "smooth muscle of bronchi" EXACT [OBOL:automatic] synonym: "smooth muscle of bronchial trunk" EXACT [OBOL:automatic] synonym: "smooth muscle of bronchus" EXACT [OBOL:automatic] synonym: "smooth muscle tissue of bronchi" EXACT [OBOL:automatic] synonym: "smooth muscle tissue of bronchial trunk" EXACT [OBOL:automatic] synonym: "smooth muscle tissue of bronchus" EXACT [OBOL:automatic] xref: BTO:0004401 xref: EMAPA:35195 xref: MA:0001840 xref: NCIT:C49213 xref: UMLS:C1707055 {source="ncithesaurus:Bronchus_Smooth_Muscle_Tissue"} is_a: UBERON:0004233 ! lower respiratory tract smooth muscle intersection_of: UBERON:0001135 ! smooth muscle tissue intersection_of: BFO:0000050 UBERON:0002185 ! part of bronchus relationship: BFO:0000050 UBERON:0002185 ! part of bronchus relationship: BFO:0000051 CL:0002598 ! has part bronchial smooth muscle cell property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "bronchus smooth muscle" xsd:string property_value: terms:contributor https://orcid.org/0000-0001-6677-8489 [Term] id: UBERON:0004243 name: prostate gland smooth muscle def: "A portion of smooth muscle tissue that is part of a prostate gland [Automatically generated definition]." [OBOL:automatic] subset: human_reference_atlas synonym: "involuntary muscle of prostate" EXACT [OBOL:automatic] synonym: "involuntary muscle of prostate gland" EXACT [OBOL:automatic] synonym: "muscular tissue of prostate" EXACT [FMA:74245] synonym: "non-striated muscle of prostate" EXACT [OBOL:automatic] synonym: "non-striated muscle of prostate gland" EXACT [OBOL:automatic] synonym: "prostate gland involuntary muscle" EXACT [OBOL:automatic] synonym: "prostate gland non-striated muscle" EXACT [OBOL:automatic] synonym: "prostate gland smooth muscle tissue" EXACT [OBOL:automatic] synonym: "prostate involuntary muscle" EXACT [OBOL:automatic] synonym: "prostate non-striated muscle" EXACT [OBOL:automatic] synonym: "prostate smooth muscle" EXACT [OBOL:automatic] synonym: "prostate smooth muscle tissue" EXACT [OBOL:automatic] synonym: "smooth muscle of prostate" EXACT [OBOL:automatic] synonym: "smooth muscle of prostate gland" EXACT [OBOL:automatic] synonym: "smooth muscle tissue of prostate" EXACT [OBOL:automatic] synonym: "smooth muscle tissue of prostate gland" EXACT [OBOL:automatic] synonym: "substantia muscularis prostatae" EXACT OMO:0003011 [FMA:74245, FMA:TA] xref: BTO:0003159 xref: EMAPA:35713 xref: FMA:74245 xref: MA:0001741 is_a: UBERON:0001135 ! smooth muscle tissue is_a: UBERON:0008715 ! muscle tissue of prostate intersection_of: UBERON:0001135 ! smooth muscle tissue intersection_of: BFO:0000050 UBERON:0002367 ! part of prostate gland relationship: BFO:0000051 CL:1000487 {source="FMA"} ! has part smooth muscle cell of prostate property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0004245 name: oviduct smooth muscle def: "A portion of smooth muscle tissue that is part of a fallopian tube [Automatically generated definition]." [OBOL:automatic] synonym: "fallopian tube involuntary muscle" EXACT [OBOL:automatic] synonym: "fallopian tube non-striated muscle" EXACT [OBOL:automatic] synonym: "fallopian tube smooth muscle" EXACT [OBOL:automatic] synonym: "fallopian tube smooth muscle tissue" EXACT [OBOL:automatic] synonym: "involuntary muscle of fallopian tube" EXACT [OBOL:automatic] synonym: "non-striated muscle of fallopian tube" EXACT [OBOL:automatic] synonym: "smooth muscle of fallopian tube" EXACT [OBOL:automatic] synonym: "smooth muscle tissue of fallopian tube" EXACT [OBOL:automatic] xref: MA:0001721 is_a: UBERON:0001135 ! smooth muscle tissue is_a: UBERON:0005156 ! reproductive structure intersection_of: UBERON:0001135 ! smooth muscle tissue intersection_of: BFO:0000050 UBERON:0003889 ! part of fallopian tube relationship: BFO:0000050 UBERON:0003889 ! part of fallopian tube [Term] id: UBERON:0004246 name: outflow tract smooth muscle def: "A portion of smooth muscle tissue that is part of a outflow tract [Automatically generated definition]." [OBOL:automatic] synonym: "involuntary muscle of outflow tract" EXACT [OBOL:automatic] synonym: "non-striated muscle of outflow tract" EXACT [OBOL:automatic] synonym: "outflow tract involuntary muscle" EXACT [OBOL:automatic] synonym: "outflow tract non-striated muscle" EXACT [OBOL:automatic] synonym: "outflow tract smooth muscle tissue" EXACT [OBOL:automatic] synonym: "smooth muscle of outflow tract" EXACT [OBOL:automatic] synonym: "smooth muscle tissue of outflow tract" EXACT [OBOL:automatic] xref: EMAPA:37708 {source="MA:th"} xref: MA:0000492 is_a: UBERON:0001135 ! smooth muscle tissue intersection_of: UBERON:0001135 ! smooth muscle tissue intersection_of: BFO:0000050 UBERON:0004145 ! part of outflow tract relationship: BFO:0000050 UBERON:0004145 ! part of outflow tract property_value: skos:prefLabel "outflow tract smooth muscle" xsd:string [Term] id: UBERON:0004247 name: bone of dorsum def: "A bone that is part of the dorsal region of an animal." [http://orcid.org/0000-0002-6601-2165] subset: grouping_class synonym: "back bone" RELATED [MA:0000494] synonym: "bone of back" RELATED [OBOL:automatic] synonym: "dorsal region bone" RELATED [http://orcid.org/0000-0002-6601-2165] xref: EMAPA:37248 {source="MA:th"} xref: MA:0000494 is_a: UBERON:0001474 ! bone element is_a: UBERON:0005174 ! dorsal region element intersection_of: UBERON:0001474 ! bone element intersection_of: BFO:0000050 UBERON:0001137 ! part of dorsum property_value: skos:prefLabel "bone of dorsum" xsd:string [Term] id: UBERON:0004248 name: pedal digit bone def: "A bone that is part of a hindlimb digit. Typically phalanges but may include sesamoids." [https://orcid.org/0000-0002-6601-2165] synonym: "bone of digit of foot" EXACT [OBOL:automatic] synonym: "digit of foot bone" EXACT [OBOL:automatic] synonym: "digital bone of foot" EXACT [] synonym: "digital bone of pes" EXACT [] synonym: "digitus pedis bone" EXACT [OBOL:automatic] synonym: "digitus pedis bone organ" EXACT [OBOL:automatic] synonym: "foot digit bone" EXACT [MA:0000646] synonym: "foot digit bone" NARROW SENSU [NCBITaxon:9606, OBOL:accepted] synonym: "foot digit bone organ" EXACT [OBOL:automatic] synonym: "hind limb digit bone" EXACT [OBOL:accepted] synonym: "toe bone" EXACT [OBOL:automatic] synonym: "toe bone organ" EXACT [OBOL:automatic] xref: EMAPA:37309 {source="MA:th"} xref: MA:0000646 is_a: UBERON:0012359 ! pedal digitopodium bone intersection_of: UBERON:0001474 ! bone element intersection_of: BFO:0000050 UBERON:0001466 ! part of pedal digit relationship: BFO:0000050 UBERON:0001466 ! part of pedal digit relationship: BFO:0000050 UBERON:5101466 ! part of pedal digit digitopodial skeleton [Term] id: UBERON:0004249 name: manual digit bone def: "A bone that is part of a forelimb digit. Typically phalanges but may include sesamoids." [https://orcid.org/0000-0002-6601-2165] synonym: "digital bone of hand" EXACT [] synonym: "digital bone of manus" EXACT [] synonym: "finger bone" EXACT [OBOL:automatic] synonym: "fore limb digit bone" EXACT [OBOL:accepted] synonym: "hand digit bone" EXACT [MA:0000622] synonym: "hand digit bone" NARROW SENSU [NCBITaxon:9606, OBOL:accepted] xref: EMAPA:37305 {source="MA:th"} xref: MA:0000622 is_a: UBERON:0012358 ! manual digitopodium bone intersection_of: UBERON:0001474 ! bone element intersection_of: BFO:0000050 UBERON:0002389 ! part of manual digit relationship: BFO:0000050 UBERON:0002389 ! part of manual digit relationship: BFO:0000050 UBERON:5102389 ! part of manual digit digitopodial skeleton [Term] id: UBERON:0004250 name: upper arm bone def: "A bone that is part of a forelimb stylopod [Automatically generated definition]." [https://sourceforge.net/tracker/index.php?func=detail&aid=3586533&group_id=76834&atid=1205376, OBOL:automatic] comment: May be merged into humerus. See: https://sourceforge.net/tracker/index.php?func=detail&aid=3586533&group_id=76834&atid=1205376 synonym: "humerus" NARROW [https://sourceforge.net/tracker/index.php?func=detail&aid=3586533&group_id=76834&atid=1205376] xref: EMAPA:35892 xref: MA:0000604 is_a: UBERON:0003460 ! arm bone intersection_of: UBERON:0001474 ! bone element intersection_of: BFO:0000050 UBERON:0003822 ! part of forelimb stylopod relationship: BFO:0000050 UBERON:0003822 ! part of forelimb stylopod [Term] id: UBERON:0004251 name: hindlimb zeugopod bone def: "A bone that is part of a lower leg [Automatically generated definition]." [OBOL:automatic] synonym: "bone of hind limb middle limb segment" EXACT [OBOL:automatic] synonym: "bone of hind limb zeugopod" EXACT [OBOL:automatic] synonym: "bone of hindlimb middle limb segment" EXACT [OBOL:automatic] synonym: "bone of hindlimb zeugopod" EXACT [OBOL:automatic] synonym: "bone of inferior member middle limb segment" EXACT [OBOL:automatic] synonym: "bone of inferior member zeugopod" EXACT [OBOL:automatic] synonym: "bone of intermediate segment of free lower limb" EXACT [OBOL:automatic] synonym: "bone of lower extremity middle limb segment" EXACT [OBOL:automatic] synonym: "bone of lower extremity zeugopod" EXACT [OBOL:automatic] synonym: "bone of lower leg" EXACT [OBOL:automatic] synonym: "bone of middle limb segment of hind limb" EXACT [OBOL:automatic] synonym: "bone of middle limb segment of hindlimb" EXACT [OBOL:automatic] synonym: "bone of middle limb segment of inferior member" EXACT [OBOL:automatic] synonym: "bone of middle limb segment of lower extremity" EXACT [OBOL:automatic] synonym: "bone of zeugopod of hind limb" EXACT [OBOL:automatic] synonym: "bone of zeugopod of hindlimb" EXACT [OBOL:automatic] synonym: "bone of zeugopod of inferior member" EXACT [OBOL:automatic] synonym: "bone of zeugopod of leg" EXACT [OBOL:automatic] synonym: "bone of zeugopod of lower extremity" EXACT [OBOL:automatic] synonym: "bone organ of hind limb middle limb segment" EXACT [OBOL:automatic] synonym: "bone organ of hind limb zeugopod" EXACT [OBOL:automatic] synonym: "bone organ of hindlimb middle limb segment" EXACT [OBOL:automatic] synonym: "bone organ of hindlimb zeugopod" EXACT [OBOL:automatic] synonym: "bone organ of inferior member middle limb segment" EXACT [OBOL:automatic] synonym: "bone organ of inferior member zeugopod" EXACT [OBOL:automatic] synonym: "bone organ of intermediate segment of free lower limb" EXACT [OBOL:automatic] synonym: "bone organ of lower extremity middle limb segment" EXACT [OBOL:automatic] synonym: "bone organ of lower extremity zeugopod" EXACT [OBOL:automatic] synonym: "bone organ of lower leg" EXACT [OBOL:automatic] synonym: "bone organ of middle limb segment of hind limb" EXACT [OBOL:automatic] synonym: "bone organ of middle limb segment of hindlimb" EXACT [OBOL:automatic] synonym: "bone organ of middle limb segment of inferior member" EXACT [OBOL:automatic] synonym: "bone organ of middle limb segment of lower extremity" EXACT [OBOL:automatic] synonym: "bone organ of zeugopod of hind limb" EXACT [OBOL:automatic] synonym: "bone organ of zeugopod of hindlimb" EXACT [OBOL:automatic] synonym: "bone organ of zeugopod of inferior member" EXACT [OBOL:automatic] synonym: "bone organ of zeugopod of leg" EXACT [OBOL:automatic] synonym: "bone organ of zeugopod of lower extremity" EXACT [OBOL:automatic] synonym: "hind limb middle limb segment bone" EXACT [OBOL:automatic] synonym: "hind limb middle limb segment bone organ" EXACT [OBOL:automatic] synonym: "hind limb zeugopod bone" EXACT [OBOL:automatic] synonym: "hind limb zeugopod bone organ" EXACT [OBOL:automatic] synonym: "hindlimb middle limb segment bone" EXACT [OBOL:automatic] synonym: "hindlimb middle limb segment bone organ" EXACT [OBOL:automatic] synonym: "hindlimb zeugopod bone" EXACT [OBOL:automatic] synonym: "hindlimb zeugopod bone organ" EXACT [OBOL:automatic] synonym: "inferior member middle limb segment bone" EXACT [OBOL:automatic] synonym: "inferior member middle limb segment bone organ" EXACT [OBOL:automatic] synonym: "inferior member zeugopod bone" EXACT [OBOL:automatic] synonym: "inferior member zeugopod bone organ" EXACT [OBOL:automatic] synonym: "intermediate segment of free lower limb bone" EXACT [OBOL:automatic] synonym: "intermediate segment of free lower limb bone organ" EXACT [OBOL:automatic] synonym: "lower extremity middle limb segment bone" EXACT [OBOL:automatic] synonym: "lower extremity middle limb segment bone organ" EXACT [OBOL:automatic] synonym: "lower extremity zeugopod bone" EXACT [OBOL:automatic] synonym: "lower extremity zeugopod bone organ" EXACT [OBOL:automatic] synonym: "lower leg bone" EXACT [MA:0000676] synonym: "middle limb segment of hind limb bone" EXACT [OBOL:automatic] synonym: "middle limb segment of hind limb bone organ" EXACT [OBOL:automatic] synonym: "middle limb segment of hindlimb bone" EXACT [OBOL:automatic] synonym: "middle limb segment of hindlimb bone organ" EXACT [OBOL:automatic] synonym: "middle limb segment of inferior member bone" EXACT [OBOL:automatic] synonym: "middle limb segment of inferior member bone organ" EXACT [OBOL:automatic] synonym: "middle limb segment of lower extremity bone" EXACT [OBOL:automatic] synonym: "middle limb segment of lower extremity bone organ" EXACT [OBOL:automatic] synonym: "zeugopod of hind limb bone" EXACT [OBOL:automatic] synonym: "zeugopod of hind limb bone organ" EXACT [OBOL:automatic] synonym: "zeugopod of hindlimb bone" EXACT [OBOL:automatic] synonym: "zeugopod of hindlimb bone organ" EXACT [OBOL:automatic] synonym: "zeugopod of inferior member bone" EXACT [OBOL:automatic] synonym: "zeugopod of inferior member bone organ" EXACT [OBOL:automatic] synonym: "zeugopod of leg bone" EXACT [OBOL:automatic] synonym: "zeugopod of leg bone organ" EXACT [OBOL:automatic] synonym: "zeugopod of lower extremity bone" EXACT [OBOL:automatic] synonym: "zeugopod of lower extremity bone organ" EXACT [OBOL:automatic] xref: EMAPA:35519 xref: MA:0000676 is_a: UBERON:0005893 ! leg bone intersection_of: UBERON:0001474 ! bone element intersection_of: BFO:0000050 UBERON:0003823 ! part of hindlimb zeugopod relationship: BFO:0000050 UBERON:0003823 ! part of hindlimb zeugopod [Term] id: UBERON:0004252 name: hindlimb stylopod muscle def: "Any muscle organ that is part of a hindlimb stylopod (upper leg)[Automatically generated definition]." [OBOL:automatic] subset: pheno_slim synonym: "muscle of thigh" EXACT [FMA:22470] synonym: "thigh muscle" EXACT [FMA:22470] synonym: "upper leg muscle" EXACT [MA:0000684] xref: BTO:0001367 xref: EMAPA:19144 xref: FMA:22470 xref: MA:0000684 xref: SCTID:245013005 is_a: UBERON:0001383 ! muscle of leg intersection_of: UBERON:0014892 ! skeletal muscle organ, vertebrate intersection_of: BFO:0000050 UBERON:0000376 ! part of hindlimb stylopod relationship: BFO:0000050 UBERON:0004463 {source="prolog"} ! part of musculature of hindlimb stylopod [Term] id: UBERON:0004253 name: skin muscle def: "Any muscle organ that is part of a skin of body [Automatically generated definition]." [OBOL:automatic] synonym: "integumental system muscle" EXACT [MA:0003139] synonym: "muscle of integumental system" EXACT [EMAPA:18187] synonym: "muscle organ of skin" EXACT [OBOL:automatic] synonym: "skin muscle organ" EXACT [OBOL:automatic] xref: EMAPA:18187 xref: EMAPA:35776 xref: MA:0002710 xref: MA:0003139 is_a: UBERON:0001630 ! muscle organ intersection_of: UBERON:0001630 ! muscle organ intersection_of: BFO:0000050 UBERON:0002416 ! part of integumental system relationship: BFO:0000050 UBERON:0002416 ! part of integumental system relationship: RO:0001025 UBERON:0002097 ! located in skin of body property_value: IAO:0000116 "review as part of general integumentary system review - part of skin, or more generally, integumental system" xsd:string property_value: skos:prefLabel "skin muscle" xsd:string [Term] id: UBERON:0004254 name: forelimb zeugopod muscle def: "Any muscle organ that is part of a forelimb zeugopod (lower arm)[Automatically generated definition]." [OBOL:automatic] synonym: "forearm muscle" EXACT [FMA:37371] synonym: "lower arm muscle" EXACT [MA:0000600] synonym: "muscle of forearm" EXACT [FMA:37371] synonym: "wing zeugopod muscle" NARROW SENSU [NCBITaxon:8782, OBOL:automatic] xref: EMAPA:32622 xref: FMA:37371 xref: MA:0000600 xref: SCTID:181631004 is_a: UBERON:0001499 ! muscle of arm intersection_of: UBERON:0014892 ! skeletal muscle organ, vertebrate intersection_of: BFO:0000050 UBERON:0002386 ! part of forelimb zeugopod relationship: BFO:0000050 UBERON:0004487 {source="prolog"} ! part of musculature of forelimb zeugopod [Term] id: UBERON:0004255 name: forelimb stylopod muscle def: "Any muscle organ that is part of a forelimb stylopod (upper arm)[Automatically generated definition]." [OBOL:automatic] subset: pheno_slim synonym: "muscle of arm" RELATED INCONSISTENT [FMA:37370] synonym: "muscle of upper arm" EXACT [MA:0000606] synonym: "skeletal muscle of upper arm" RELATED [EMAPA:19107] synonym: "upper arm muscle" EXACT [MA:0000606] synonym: "wing stylopod muscle" NARROW SENSU [NCBITaxon:8782, OBOL:automatic] xref: EMAPA:19107 xref: FMA:37370 xref: MA:0000606 xref: SCTID:244979005 is_a: UBERON:0001499 ! muscle of arm intersection_of: UBERON:0014892 ! skeletal muscle organ, vertebrate intersection_of: BFO:0000050 UBERON:0003822 ! part of forelimb stylopod relationship: BFO:0000050 UBERON:0014791 {source="prolog"} ! part of musculature of forelimb stylopod property_value: IAO:0000116 "the FMA class 'muscle of arm' belongs here, do not move" xsd:string [Term] id: UBERON:0004256 name: hindlimb zeugopod muscle def: "Any muscle organ that is part of a hindlimb zeugopod (lower leg) [Automatically generated definition]." [OBOL:automatic] subset: human_reference_atlas subset: pheno_slim synonym: "calf muscle" RELATED [OBOL:automatic] synonym: "lower leg muscle" EXACT [MA:0000678] synonym: "muscle of leg" RELATED INCONSISTENT [FMA:22471] xref: EMAPA:19318 xref: FMA:22471 xref: MA:0000678 xref: SCTID:265806001 is_a: UBERON:0001383 ! muscle of leg intersection_of: UBERON:0014892 ! skeletal muscle organ, vertebrate intersection_of: BFO:0000050 UBERON:0003823 ! part of hindlimb zeugopod relationship: BFO:0000050 UBERON:0006067 {source="prolog"} ! part of musculature of hindlimb zeugopod property_value: IAO:0000116 "the FMA class 'muscle of leg' belongs here, do not move[cjm]" xsd:string property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0004257 name: upper leg blood vessel def: "A blood vessel that is part of a hindlimb stylopod [Automatically generated definition]." [OBOL:automatic] synonym: "blood vessel of stylopod of hind limb" EXACT [OBOL:automatic] synonym: "blood vessel of stylopod of hindlimb" EXACT [OBOL:automatic] synonym: "blood vessel of thigh" EXACT [OBOL:automatic] synonym: "blood vessel of upper leg" EXACT [OBOL:automatic] synonym: "hind limb stylopod blood vessel" EXACT [OBOL:automatic] synonym: "hindlimb stylopod blood vessel" EXACT [OBOL:automatic] synonym: "thigh blood vessel" EXACT [OBOL:automatic] xref: EMAPA:37299 {source="MA:th"} xref: MA:0000681 is_a: UBERON:0003503 ! leg blood vessel intersection_of: UBERON:0001981 ! blood vessel intersection_of: BFO:0000050 UBERON:0000376 ! part of hindlimb stylopod relationship: BFO:0000050 UBERON:0000376 ! part of hindlimb stylopod [Term] id: UBERON:0004258 name: back blood vessel def: "A blood vessel that is part of a back [Automatically generated definition]." [OBOL:automatic] synonym: "blood vessel of back" EXACT [OBOL:automatic] xref: EMAPA:37243 {source="MA:th"} xref: MA:0000493 is_a: UBERON:0001981 ! blood vessel intersection_of: UBERON:0001981 ! blood vessel intersection_of: BFO:0000050 UBERON:0001137 ! part of dorsum relationship: BFO:0000050 UBERON:0001137 ! part of dorsum property_value: skos:prefLabel "back blood vessel" xsd:string [Term] id: UBERON:0004259 name: lower arm blood vessel def: "A blood vessel that is part of a lower arm [Automatically generated definition]." [OBOL:automatic] synonym: "forelimb zeugopod blood vessel" EXACT [https://orcid.org/0000-0002-6601-2165] xref: EMAPA:37295 {source="MA:th"} xref: MA:0000597 is_a: UBERON:0003507 ! arm blood vessel intersection_of: UBERON:0001981 ! blood vessel intersection_of: BFO:0000050 UBERON:0002386 ! part of forelimb zeugopod relationship: BFO:0000050 UBERON:0002386 ! part of forelimb zeugopod [Term] id: UBERON:0004260 name: upper arm blood vessel def: "A blood vessel that is part of a forelimb stylopod [Automatically generated definition]." [OBOL:automatic] synonym: "forelimb stylopod blood vessel" EXACT [https://orcid.org/0000-0002-6601-2165] xref: EMAPA:37294 {source="MA:th"} xref: MA:0000603 is_a: UBERON:0003507 ! arm blood vessel intersection_of: UBERON:0001981 ! blood vessel intersection_of: BFO:0000050 UBERON:0003822 ! part of forelimb stylopod relationship: BFO:0000050 UBERON:0003822 ! part of forelimb stylopod [Term] id: UBERON:0004261 name: lower leg blood vessel def: "A blood vessel that is part of a lower leg [Automatically generated definition]." [OBOL:automatic] synonym: "hindlimb zeugopod blood vessel" EXACT [https://orcid.org/0000-0002-6601-2165] xref: EMAPA:37300 {source="MA:th"} xref: MA:0000675 is_a: UBERON:0003503 ! leg blood vessel intersection_of: UBERON:0001981 ! blood vessel intersection_of: BFO:0000050 UBERON:0003823 ! part of hindlimb zeugopod relationship: BFO:0000050 UBERON:0003823 ! part of hindlimb zeugopod [Term] id: UBERON:0004262 name: upper leg skin def: "A zone of skin that is part of a hindlimb stylopod [Automatically generated definition]." [OBOL:automatic] synonym: "hind limb stylopod skin" EXACT [OBOL:automatic] synonym: "hindlimb stylopod skin" EXACT [OBOL:automatic] synonym: "skin of thigh" RELATED [OBOL:automatic] synonym: "skin of upper leg" EXACT [OBOL:automatic] synonym: "thigh skin" RELATED [OBOL:automatic] xref: EMAPA:18159 xref: FMA:37790 xref: MA:0000686 xref: SCTID:181547006 is_a: UBERON:0001511 ! skin of leg intersection_of: UBERON:0000014 ! zone of skin intersection_of: BFO:0000050 UBERON:0000376 ! part of hindlimb stylopod relationship: BFO:0000050 UBERON:0000376 ! part of hindlimb stylopod [Term] id: UBERON:0004263 name: upper arm skin def: "A zone of skin that is part of a forelimb stylopod [Automatically generated definition]." [OBOL:automatic] synonym: "arm stylopod skin" EXACT [OBOL:automatic] synonym: "skin of arm stylopod" EXACT [OBOL:automatic] synonym: "skin of upper arm" EXACT [OBOL:automatic] xref: EMAPA:18062 xref: FMA:37721 xref: MA:0000608 xref: SCTID:181531009 is_a: UBERON:0002427 ! arm skin intersection_of: UBERON:0000014 ! zone of skin intersection_of: BFO:0000050 UBERON:0003822 ! part of forelimb stylopod relationship: BFO:0000050 UBERON:0003822 ! part of forelimb stylopod [Term] id: UBERON:0004264 name: lower leg skin def: "A zone of skin that is part of a lower leg [Automatically generated definition]." [OBOL:automatic] synonym: "hind limb middle limb segment skin" EXACT [OBOL:automatic] synonym: "hind limb zeugopod skin" EXACT [OBOL:automatic] synonym: "hindlimb zeugopod skin" EXACT [https://orcid.org/0000-0002-0819-0473] xref: EMAPA:18156 xref: MA:0000680 xref: SCTID:244180007 is_a: UBERON:0001511 ! skin of leg intersection_of: UBERON:0000014 ! zone of skin intersection_of: BFO:0000050 UBERON:0003823 ! part of hindlimb zeugopod relationship: BFO:0000050 UBERON:0003823 ! part of hindlimb zeugopod [Term] id: UBERON:0004265 name: outflow tract myocardium def: "A myocardium that is part of a outflow tract [Automatically generated definition]." [OBOL:automatic] synonym: "cardiac muscle of outflow tract" EXACT [OBOL:automatic] synonym: "heart muscle of outflow tract" EXACT [OBOL:automatic] synonym: "heart myocardium of outflow tract" EXACT [OBOL:automatic] synonym: "muscle of heart of outflow tract" EXACT [OBOL:automatic] synonym: "myocardium of outflow tract" EXACT [OBOL:automatic] synonym: "outflow tract cardiac muscle" EXACT [OBOL:automatic] synonym: "outflow tract heart muscle" EXACT [OBOL:automatic] synonym: "outflow tract heart myocardium" EXACT [OBOL:automatic] synonym: "outflow tract muscle of heart" EXACT [OBOL:automatic] xref: EHDAA2:0001358 xref: EMAPA:35623 xref: MA:0000489 xref: VHOG:0000603 is_a: UBERON:0002349 ! myocardium intersection_of: UBERON:0002349 ! myocardium intersection_of: BFO:0000050 UBERON:0004145 ! part of outflow tract relationship: BFO:0000050 UBERON:0004145 ! part of outflow tract property_value: skos:prefLabel "outflow tract myocardium" xsd:string [Term] id: UBERON:0004266 name: upper leg connective tissue def: "A portion of connective tissue that is part of a hindlimb stylopod [Automatically generated definition]." [OBOL:automatic] xref: EMAPA:37325 {source="MA:th"} xref: MA:0000683 is_a: UBERON:0003569 ! leg connective tissue intersection_of: UBERON:0002384 ! connective tissue intersection_of: BFO:0000050 UBERON:0000376 ! part of hindlimb stylopod relationship: BFO:0000050 UBERON:0000376 ! part of hindlimb stylopod relationship: RO:0002494 UBERON:0005254 ! transformation of upper leg mesenchyme [Term] id: UBERON:0004267 name: back connective tissue def: "A portion of connective tissue that is part of a back [Automatically generated definition]." [OBOL:automatic] synonym: "mesenchyne of back" RELATED [OBOL:automatic] xref: EMAPA:37256 {source="MA:th"} xref: MA:0000495 is_a: UBERON:0002384 ! connective tissue intersection_of: UBERON:0002384 ! connective tissue intersection_of: BFO:0000050 UBERON:0001137 ! part of dorsum relationship: BFO:0000050 UBERON:0001137 ! part of dorsum property_value: skos:prefLabel "back connective tissue" xsd:string [Term] id: UBERON:0004268 name: lower arm connective tissue def: "A portion of connective tissue that is part of a lower arm [Automatically generated definition]." [OBOL:automatic] xref: EMAPA:37319 {source="MA:th"} xref: MA:0000599 is_a: UBERON:0003573 ! arm connective tissue intersection_of: UBERON:0002384 ! connective tissue intersection_of: BFO:0000050 UBERON:0002386 ! part of forelimb zeugopod relationship: BFO:0000050 UBERON:0002386 ! part of forelimb zeugopod relationship: RO:0002494 UBERON:0003327 ! transformation of mesenchyme of forearm [Term] id: UBERON:0004269 name: upper arm connective tissue def: "A portion of connective tissue that is part of a forelimb stylopod [Automatically generated definition]." [OBOL:automatic] xref: EMAPA:37317 {source="MA:th"} xref: MA:0000605 is_a: UBERON:0003573 ! arm connective tissue intersection_of: UBERON:0002384 ! connective tissue intersection_of: BFO:0000050 UBERON:0003822 ! part of forelimb stylopod relationship: BFO:0000050 UBERON:0003822 ! part of forelimb stylopod relationship: RO:0002494 UBERON:0005258 ! transformation of upper arm mesenchyme [Term] id: UBERON:0004270 name: lower leg connective tissue def: "A portion of connective tissue that is part of a lower leg [Automatically generated definition]." [OBOL:automatic] xref: EMAPA:37327 {source="MA:th"} xref: MA:0000677 is_a: UBERON:0003569 ! leg connective tissue intersection_of: UBERON:0002384 ! connective tissue intersection_of: BFO:0000050 UBERON:0003823 ! part of hindlimb zeugopod relationship: BFO:0000050 UBERON:0003823 ! part of hindlimb zeugopod relationship: RO:0002494 UBERON:0005259 ! transformation of lower leg mesenchyme [Term] id: UBERON:0004271 name: outflow tract pericardium def: "A pericardium that is part of a outflow tract [Automatically generated definition]." [OBOL:automatic] synonym: "pericardium of outflow tract" EXACT [OBOL:automatic] xref: EMAPA:37707 {source="MA:th"} xref: MA:0000491 is_a: UBERON:0002407 ! pericardium intersection_of: UBERON:0002407 ! pericardium intersection_of: BFO:0000050 UBERON:0004145 ! part of outflow tract relationship: BFO:0000050 UBERON:0004145 ! part of outflow tract property_value: skos:prefLabel "outflow tract pericardium" xsd:string [Term] id: UBERON:0004273 name: cartilaginous joint suture def: "A cranial suture that is part of a cartilaginous joint [Automatically generated definition]." [OBOL:automatic] synonym: "articulatio cartilaginea cranial suture" EXACT [OBOL:automatic] synonym: "articulatio cartilaginea cranial sutures" EXACT [OBOL:automatic] synonym: "articulatio cartilaginea cranial sutures set" EXACT [OBOL:automatic] synonym: "articulatio cartilaginea cranium suture" EXACT [OBOL:automatic] synonym: "articulatio cartilaginea suture of cranium" EXACT [OBOL:automatic] synonym: "cartilaginous joint cranial suture" EXACT [OBOL:automatic] synonym: "cartilaginous joint cranial sutures" EXACT [OBOL:automatic] synonym: "cartilaginous joint cranial sutures set" EXACT [OBOL:automatic] synonym: "cartilaginous joint cranium suture" EXACT [OBOL:automatic] synonym: "cartilaginous joint suture of cranium" EXACT [OBOL:automatic] synonym: "cranial suture of articulatio cartilaginea" EXACT [OBOL:automatic] synonym: "cranial suture of cartilaginous joint" EXACT [OBOL:automatic] synonym: "cranial sutures of articulatio cartilaginea" EXACT [OBOL:automatic] synonym: "cranial sutures of cartilaginous joint" EXACT [OBOL:automatic] synonym: "cranial sutures set of articulatio cartilaginea" EXACT [OBOL:automatic] synonym: "cranial sutures set of cartilaginous joint" EXACT [OBOL:automatic] synonym: "cranium suture of articulatio cartilaginea" EXACT [OBOL:automatic] synonym: "cranium suture of cartilaginous joint" EXACT [OBOL:automatic] synonym: "suture of cranium of articulatio cartilaginea" EXACT [OBOL:automatic] synonym: "suture of cranium of cartilaginous joint" EXACT [OBOL:automatic] xref: EMAPA:37463 {source="MA:th"} xref: MA:0001498 is_a: UBERON:0003685 ! cranial suture intersection_of: UBERON:0003685 ! cranial suture intersection_of: BFO:0000050 UBERON:0002213 ! part of cartilaginous joint relationship: BFO:0000050 UBERON:0002213 ! part of cartilaginous joint property_value: skos:prefLabel "cartilaginous joint suture" xsd:string [Term] id: UBERON:0004274 name: lateral ventricle choroid plexus epithelium def: "A choroid plexus epithelium that is part of a lateral ventricle [Automatically generated definition]." [OBOL:automatic] synonym: "chorioid plexus of cerebral hemisphere epithelial tissue of lateral ventricle" EXACT [OBOL:automatic] synonym: "chorioid plexus of cerebral hemisphere epithelium of lateral ventricle" EXACT [OBOL:automatic] synonym: "choroid plexus epithelial tissue of lateral ventricle" EXACT [OBOL:automatic] synonym: "choroid plexus epithelium of lateral ventricle" EXACT [OBOL:automatic] synonym: "epithelial tissue of chorioid plexus of cerebral hemisphere of lateral ventricle" EXACT [OBOL:automatic] synonym: "epithelial tissue of choroid plexus of lateral ventricle" EXACT [OBOL:automatic] synonym: "epithelium of chorioid plexus of cerebral hemisphere of lateral ventricle" EXACT [OBOL:automatic] synonym: "epithelium of choroid plexus of lateral ventricle" EXACT [OBOL:automatic] synonym: "lateral ventricle chorioid plexus of cerebral hemisphere epithelial tissue" EXACT [OBOL:automatic] synonym: "lateral ventricle chorioid plexus of cerebral hemisphere epithelium" EXACT [OBOL:automatic] synonym: "lateral ventricle choroid plexus epithelial tissue" EXACT [OBOL:automatic] synonym: "lateral ventricle epithelial tissue of chorioid plexus of cerebral hemisphere" EXACT [OBOL:automatic] synonym: "lateral ventricle epithelial tissue of choroid plexus" EXACT [OBOL:automatic] synonym: "lateral ventricle epithelium of chorioid plexus of cerebral hemisphere" EXACT [OBOL:automatic] synonym: "lateral ventricle epithelium of choroid plexus" EXACT [OBOL:automatic] xref: EHDAA2:0004450 xref: FMA:242815 xref: MA:0000962 xref: NCIT:C49248 xref: UMLS:C1711323 {source="ncithesaurus:Choroid_Plexus_Epithelium_of_the_Lateral_Ventricle"} is_a: UBERON:0003911 ! choroid plexus epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: BFO:0000050 UBERON:0002307 ! part of choroid plexus of lateral ventricle relationship: BFO:0000050 UBERON:0002307 ! part of choroid plexus of lateral ventricle property_value: skos:prefLabel "lateral ventricle choroid plexus epithelium" xsd:string [Term] id: UBERON:0004275 name: third ventricle choroid plexus epithelium def: "A choroid plexus epithelium that is part of a third ventricle [Automatically generated definition]." [OBOL:automatic] synonym: "chorioid plexus of cerebral hemisphere epithelial tissue of third ventricle" EXACT [OBOL:automatic] synonym: "chorioid plexus of cerebral hemisphere epithelium of third ventricle" EXACT [OBOL:automatic] synonym: "choroid plexus epithelial tissue of third ventricle" EXACT [OBOL:automatic] synonym: "choroid plexus epithelium of third ventricle" EXACT [OBOL:automatic] synonym: "epithelial tissue of chorioid plexus of cerebral hemisphere of third ventricle" EXACT [OBOL:automatic] synonym: "epithelial tissue of choroid plexus of third ventricle" EXACT [OBOL:automatic] synonym: "epithelium of chorioid plexus of cerebral hemisphere of third ventricle" EXACT [OBOL:automatic] synonym: "epithelium of choroid plexus of third ventricle" EXACT [OBOL:automatic] synonym: "third ventricle chorioid plexus of cerebral hemisphere epithelial tissue" EXACT [OBOL:automatic] synonym: "third ventricle chorioid plexus of cerebral hemisphere epithelium" EXACT [OBOL:automatic] synonym: "third ventricle choroid plexus epithelial tissue" EXACT [OBOL:automatic] synonym: "third ventricle epithelial tissue of chorioid plexus of cerebral hemisphere" EXACT [OBOL:automatic] synonym: "third ventricle epithelial tissue of choroid plexus" EXACT [OBOL:automatic] synonym: "third ventricle epithelium of chorioid plexus of cerebral hemisphere" EXACT [OBOL:automatic] synonym: "third ventricle epithelium of choroid plexus" EXACT [OBOL:automatic] xref: EMAPA:37055 {source="MA:th"} xref: FMA:242821 xref: MA:0000880 is_a: UBERON:0003911 ! choroid plexus epithelium intersection_of: UBERON:0003911 ! choroid plexus epithelium intersection_of: BFO:0000050 UBERON:0002286 ! part of third ventricle relationship: BFO:0000050 UBERON:0002288 ! part of choroid plexus of third ventricle property_value: skos:prefLabel "third ventricle choroid plexus epithelium" xsd:string [Term] id: UBERON:0004276 name: fourth ventricle choroid plexus epithelium def: "A choroid plexus epithelium that is part of a fourth ventricle [Automatically generated definition]." [OBOL:automatic] synonym: "chorioid plexus of cerebral hemisphere epithelial tissue of fourth ventricle" EXACT [OBOL:automatic] synonym: "chorioid plexus of cerebral hemisphere epithelium of fourth ventricle" EXACT [OBOL:automatic] synonym: "choroid plexus epithelial tissue of fourth ventricle" EXACT [OBOL:automatic] synonym: "choroid plexus epithelium of fourth ventricle" EXACT [OBOL:automatic] synonym: "epithelial tissue of chorioid plexus of cerebral hemisphere of fourth ventricle" EXACT [OBOL:automatic] synonym: "epithelial tissue of choroid plexus of fourth ventricle" EXACT [OBOL:automatic] synonym: "epithelium of chorioid plexus of cerebral hemisphere of fourth ventricle" EXACT [OBOL:automatic] synonym: "epithelium of choroid plexus of fourth ventricle" EXACT [OBOL:automatic] synonym: "fourth ventricle chorioid plexus of cerebral hemisphere epithelial tissue" EXACT [OBOL:automatic] synonym: "fourth ventricle chorioid plexus of cerebral hemisphere epithelium" EXACT [OBOL:automatic] synonym: "fourth ventricle choroid plexus epithelial tissue" EXACT [OBOL:automatic] synonym: "fourth ventricle epithelial tissue of chorioid plexus of cerebral hemisphere" EXACT [OBOL:automatic] synonym: "fourth ventricle epithelial tissue of choroid plexus" EXACT [OBOL:automatic] synonym: "fourth ventricle epithelium of chorioid plexus of cerebral hemisphere" EXACT [OBOL:automatic] synonym: "fourth ventricle epithelium of choroid plexus" EXACT [OBOL:automatic] xref: FMA:242823 xref: MA:0000984 xref: NCIT:C49230 xref: UMLS:C1707392 {source="ncithesaurus:Choroid_Plexus_Epithelium_of_the_Fourth_Ventricle"} is_a: UBERON:0003911 ! choroid plexus epithelium intersection_of: UBERON:0003911 ! choroid plexus epithelium intersection_of: BFO:0000050 UBERON:0002422 ! part of fourth ventricle relationship: BFO:0000050 UBERON:0002290 ! part of choroid plexus of fourth ventricle property_value: skos:prefLabel "fourth ventricle choroid plexus epithelium" xsd:string [Term] id: UBERON:0004277 name: eye muscle def: "A muscle that is part of the eye region." [OBOL:automatic] subset: pheno_slim xref: AAO:0000156 xref: EMAPA:35335 xref: MA:0000271 is_a: UBERON:0001630 ! muscle organ intersection_of: UBERON:0001630 ! muscle organ intersection_of: BFO:0000050 UBERON:0000019 ! part of camera-type eye relationship: BFO:0000050 UBERON:0000019 {source="MA"} ! part of camera-type eye relationship: RO:0002433 UBERON:0000019 ! contributes to morphology of camera-type eye property_value: skos:prefLabel "eye muscle" xsd:string [Term] id: UBERON:0004288 name: skeleton def: "Anatomical cluster that consists of all the skeletal elements (eg., bone, cartilage, and teeth) of the body." [VSAO:0000026] subset: efo_slim subset: human_reference_atlas subset: pheno_slim subset: uberon_slim synonym: "set of all bones" EXACT [] synonym: "set of bones of body" EXACT [] xref: AEO:0000168 xref: EHDAA2:0001843 xref: EHDAA:5047 xref: EMAPA:17213 xref: FMA:23875 xref: GAID:177 xref: galen:Skeleton xref: MA:0003006 xref: MAT:0000032 xref: MESH:D012863 xref: MIAA:0000032 xref: SCTID:361378004 xref: VSAO:0000026 xref: Wikipedia:Skeleton xref: XAO:0004053 is_a: BFO:0000004 is_a: UBERON:0034925 ! anatomical collection disjoint_from: UBERON:0004770 ! articular system relationship: BFO:0000050 UBERON:0001434 ! part of skeletal system relationship: RO:0002351 UBERON:0004765 ! has member skeletal element property_value: RO:0002175 NCBITaxon:9606 property_value: seeAlso "https://github.com/obophenotype/uberon/wiki/The-skeletal-system" xsd:anyURI property_value: skos:prefLabel "skeleton" xsd:string [Term] id: UBERON:0004290 name: dermomyotome def: "The bilaminar epithelium formed from the myotome and dermatome." [AEO:0000214] synonym: "dermamyotome" RELATED [VHOG:0000676] synonym: "dermomyotomes" RELATED OMO:0003004 [VHOG:0000676] xref: AAO:0010572 xref: AEO:0000214 xref: EHDAA2:0003259 xref: EMAPA:31109 xref: FMA:295654 xref: NCIT:C34140 xref: TAO:0001513 xref: UMLS:C1511786 {source="ncithesaurus:Dermomyotome"} xref: VHOG:0000676 xref: ZFA:0001513 is_a: BFO:0000002 is_a: UBERON:0000486 {source="AEO"} ! multilaminar epithelium is_a: UBERON:0016888 {source="AEO"} ! transitional anatomical structure relationship: BFO:0000051 CL:0000075 ! has part columnar/cuboidal epithelial cell relationship: RO:0002202 UBERON:0002329 {source="EHDAA2", source="ZFA"} ! develops from somite property_value: skos:prefLabel "dermomyotome" xsd:string [Term] id: UBERON:0004291 name: heart rudiment def: "A cone-like structure that is formed when myocardial progenitor cells of the heart field fuse at the midline. The heart rudiment is the first structure of the heart tube." [GO:0003313] synonym: "heart cone" EXACT [GO:0003313] synonym: "rudimentary heart" EXACT [ZFA:0000115] xref: TAO:0000115 xref: ZFA:0000115 is_a: UBERON:0012275 ! meso-epithelium relationship: RO:0002202 UBERON:0004139 ! develops from cardiogenic plate property_value: skos:prefLabel "heart rudiment" xsd:string [Term] id: UBERON:0004292 name: cardiac skeleton def: "Dense connective tissue that separates the atria from the ventricles and provides physical support for the heart." [GO:0003204, Wikipedia:Cardiac_skeleton] synonym: "anulus fibrosus dexter cordis" RELATED OMO:0003011 [Wikipedia:Cardiac_skeleton] synonym: "anulus fibrosus sinister cordis" RELATED OMO:0003011 [Wikipedia:Cardiac_skeleton] synonym: "cardiac fibrous skeleton" EXACT [EMAPA:36645] synonym: "fibrous skeleton of heart" EXACT [] synonym: "heart fibrous skeleton" EXACT [GO:0003204] synonym: "skeleton of heart" EXACT [FMA:9496] synonym: "trigona fibrosa" RELATED OMO:0003011 [Wikipedia:Cardiac_skeleton] synonym: "trigonum fibrosum dextrum cordis" RELATED OMO:0003011 [Wikipedia:Cardiac_skeleton] synonym: "trigonum fibrosum sinistrum cordis" RELATED OMO:0003011 [Wikipedia:Cardiac_skeleton] xref: EMAPA:36645 xref: FMA:9496 xref: Wikipedia:Cardiac_skeleton is_a: UBERON:0003837 ! thoracic segment connective tissue relationship: BFO:0000050 UBERON:0000948 ! part of heart relationship: RO:0002220 UBERON:0002081 ! adjacent to cardiac atrium relationship: RO:0002220 UBERON:0002082 ! adjacent to cardiac ventricle property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/5/50/Gray495.png" xsd:anyURI property_value: skos:prefLabel "cardiac skeleton" xsd:string [Term] id: UBERON:0004293 name: parasympathetic nerve def: "A nerve that is part of a parasympathetic nervous system [Automatically generated definition]." [OBOL:automatic] subset: human_reference_atlas synonym: "nerve of parasympathetic nervous system" EXACT [OBOL:automatic] xref: EHDAA2:0001401 xref: EMAPA:17271 xref: MA:0000224 xref: SCTID:276146002 xref: VHOG:0000641 is_a: BFO:0000002 is_a: UBERON:0001021 ! nerve intersection_of: UBERON:0001021 ! nerve intersection_of: BFO:0000050 UBERON:0000011 ! part of parasympathetic nervous system relationship: BFO:0000050 UBERON:0000011 ! part of parasympathetic nervous system relationship: extends_fibers_into UBERON:0001808 ! parasympathetic ganglion relationship: RO:0002254 UBERON:0005428 {source="NCBIBook:NBK10065"} ! has developmental contribution from vagal neural crest relationship: RO:0002254 UBERON:0010075 {source="NCBIBook:NBK10065"} ! has developmental contribution from sacral neural crest property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "parasympathetic nerve" xsd:string [Term] id: UBERON:0004294 name: glomerular capillary endothelium def: "An endothelium that is part of a glomerular capillary." [OBOL:automatic] subset: human_reference_atlas subset: pheno_slim synonym: "renal glomerulus capillary endothelium" EXACT [OBOL:automatic] xref: MA:0001658 xref: NCIT:C32522 xref: SCTID:243993006 xref: UMLS:C0227647 {source="ncithesaurus:Endothelium_of_the_Glomerular_Capillary"} is_a: UBERON:0001915 ! endothelium of capillary is_a: UBERON:0004189 ! glomerular endothelium intersection_of: UBERON:0001986 ! endothelium intersection_of: BFO:0000050 UBERON:0004212 ! part of glomerular capillary relationship: BFO:0000050 UBERON:0004212 ! part of glomerular capillary relationship: RO:0002433 UBERON:0004212 ! contributes to morphology of glomerular capillary property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0004295 name: sympathetic nerve trunk def: "A nerve trunk that is part of a sympathetic nervous system [Automatically generated definition]." [OBOL:automatic] subset: pheno_slim synonym: "nerve trunk of sympathetic nervous system" EXACT [OBOL:automatic] synonym: "nerve trunk of sympathetic part of autonomic division of nervous system" EXACT [OBOL:automatic] synonym: "sympathetic nervous system nerve trunk" EXACT [OBOL:automatic] xref: EHDAA2:0001970 xref: EMAPA:35845 xref: MA:0000227 is_a: UBERON:0002464 ! nerve trunk intersection_of: UBERON:0002464 ! nerve trunk intersection_of: BFO:0000050 UBERON:0000013 ! part of sympathetic nervous system relationship: BFO:0000050 UBERON:0000013 ! part of sympathetic nervous system [Term] id: UBERON:0004296 name: respiratory system lymphatic vessel smooth muscle def: "A lymphatic vessel smooth muscle that is part of a respiratory system [Automatically generated definition]." [OBOL:automatic] synonym: "smooth muscle of lymph vessel of respiratory system" EXACT [OBOL:automatic] xref: EMAPA:37582 {source="MA:th"} xref: MA:0001826 is_a: UBERON:0004225 ! respiratory system smooth muscle is_a: UBERON:0004232 ! lymphatic vessel smooth muscle intersection_of: UBERON:0001135 ! smooth muscle tissue intersection_of: BFO:0000050 UBERON:0003456 ! part of respiratory system lymphatic vessel relationship: BFO:0000050 UBERON:0003456 ! part of respiratory system lymphatic vessel [Term] id: UBERON:0004297 name: respiratory system blood vessel smooth muscle def: "A blood vessel smooth muscle that is part of a respiratory system [Automatically generated definition]." [OBOL:automatic] synonym: "smooth muscle tissue of blood vessel of respiratory system" EXACT [OBOL:automatic] xref: EMAPA:37573 {source="MA:th"} xref: MA:0001806 is_a: UBERON:0004225 ! respiratory system smooth muscle is_a: UBERON:0004237 ! blood vessel smooth muscle intersection_of: UBERON:0001135 ! smooth muscle tissue intersection_of: BFO:0000050 UBERON:0003504 ! part of respiratory system blood vessel relationship: BFO:0000050 UBERON:0003504 ! part of respiratory system blood vessel property_value: skos:prefLabel "respiratory system blood vessel smooth muscle" xsd:string [Term] id: UBERON:0004300 name: distal phalanx def: "Distal-most phalanx within a digit." [http://orcid.org/0000-0002-6601-2165, https://github.com/obophenotype/uberon/issues/120] subset: pheno_slim synonym: "phalanx distalis" EXACT [Wikipedia:Distal_phalanges] synonym: "phalanx distalis" RELATED OMO:0003011 [Wikipedia:Distal_phalanges] synonym: "terminal phalanx" EXACT [AAO:0010676] synonym: "ungual phalanx" EXACT [http://www.medilexicon.com/medicaldictionary.php?t=67679] xref: AAO:0010676 xref: EMAPA:35287 xref: MA:0002914 xref: SCTID:299711006 xref: Wikipedia:Distal_phalanges is_a: UBERON:0003221 ! phalanx intersection_of: UBERON:0003221 ! phalanx intersection_of: proximally_connected_to UBERON:0004301 ! middle phalanx relationship: BFO:0000050 UBERON:0009551 ! part of distal segment of digit relationship: proximally_connected_to UBERON:0004301 ! middle phalanx property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/a/ab/Scheme_human_hand_bones-en.svg" xsd:anyURI property_value: terms:contributor https://orcid.org/0000-0001-9114-8737 property_value: terms:contributor https://orcid.org/0000-0002-6601-2165 [Term] id: UBERON:0004301 name: middle phalanx def: "A phalanx located between proximal and distal phalanges." [http://orcid.org/0000-0002-6601-2165] synonym: "intermediate phalanx" EXACT [] synonym: "medial phalanx" RELATED [] synonym: "penultimate phalanx" RELATED [AAO:0010677] synonym: "phalanx 2" RELATED [] synonym: "phalanx II" RELATED [] xref: AAO:0010677 xref: EMAPA:35572 xref: MA:0002915 xref: SCTID:299710007 xref: Wikipedia:Intermediate_phalanges is_a: UBERON:0003221 ! phalanx intersection_of: UBERON:0003221 ! phalanx intersection_of: distally_connected_to UBERON:0003221 ! phalanx intersection_of: proximally_connected_to UBERON:0003221 ! phalanx relationship: distally_connected_to UBERON:0004300 ! distal phalanx relationship: proximally_connected_to UBERON:0004302 ! proximal phalanx property_value: IAO:0000116 "consider using numbering system, and axioms to the effect that there is a single middle phalanx per finger in humans. This should perhaps be renamed 'intermediate phalanx', leaving the term middle phalanx open for the specific intermediate phalanx of a 3-phalanx digit" xsd:string [Term] id: UBERON:0004302 name: proximal phalanx def: "Proximal-most phalanx within a digit." [http://orcid.org/0000-0002-6601-2165] synonym: "phalanx 1" EXACT [] synonym: "phalanx I" EXACT [] synonym: "proximal-most phalanx" EXACT [AAO:0010680] xref: AAO:0010680 xref: EMAPA:35716 xref: MA:0002916 xref: SCTID:299708005 xref: Wikipedia:Proximal_phalanges is_a: UBERON:0003221 ! phalanx intersection_of: UBERON:0003221 ! phalanx intersection_of: RO:0002170 UBERON:0003821 ! connected to metapodium bone relationship: RO:0002170 UBERON:0003821 ! connected to metapodium bone [Term] id: UBERON:0004340 name: allantois def: "A membranous sac that develops from the posterior part of the alimentary canal in the embryos of mammals, birds, and reptiles, and it is important in the formation of the umbilical cord and placenta in mammals[VHOG]." [VHOG:0000738, Wikipedia:Allantois] subset: pheno_slim synonym: "allantoic bud" RELATED [EMAPA:16107] xref: BTO:0000474 xref: EHDAA2:0001504 xref: EMAPA:16107 xref: EMAPA_RETIRED:16084 xref: MESH:D000482 xref: NCIT:C34101 xref: RETIRED_EHDAA2:0000114 xref: SCTID:308825007 xref: UMLS:C0002084 {source="ncithesaurus:Allantois"} xref: VHOG:0000738 xref: Wikipedia:Allantois is_a: BFO:0000002 is_a: UBERON:0005631 ! extraembryonic membrane relationship: RO:0002131 UBERON:0001008 {source="EHDAA2-modified"} ! overlaps renal system relationship: RO:0002162 NCBITaxon:32524 {source="Hymans"} ! in taxon Amniota relationship: RO:0002202 UBERON:0000162 {source="Hymans"} ! develops from cloaca relationship: RO:0002254 UBERON:0000925 ! has developmental contribution from endoderm relationship: RO:0002254 UBERON:0004872 {source="ISBN:0073040584"} ! has developmental contribution from splanchnic layer of lateral plate mesoderm property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/a/a5/Gray25.png" xsd:anyURI [Term] id: UBERON:0004341 name: primitive streak def: "The primitive streak is a structure that forms during the early stages of avian, reptilian and mammalian embryonic development[WP]. the midline ridge of the embryonic epiblast that later develops into mesoderm and endoderm[MP]." [MP:0002231, Wikipedia:Primitive_streak] subset: early_development subset: pheno_slim synonym: "primitive streak - blastopore - germ ring" EXACT [VHOG:0001202] xref: EHDAA2:0001525 xref: EHDAA:185 xref: EMAPA:16072 xref: FMA:293110 xref: NCIT:C28402 xref: SCTID:361438007 xref: UMLS:C0033153 {source="ncithesaurus:Primitive_Streak"} xref: VHOG:0001202 xref: Wikipedia:Primitive_streak is_a: UBERON:0000485 {source="EHDAA2"} ! simple columnar epithelium is_a: UBERON:0005291 ! embryonic tissue relationship: RO:0002387 UBERON:0000925 ! has potential to develop into endoderm relationship: RO:0002387 UBERON:0000926 ! has potential to develop into mesoderm property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/f/f4/Gray13.png" xsd:anyURI [Term] id: UBERON:0004345 name: trophectoderm def: "Outermost layer of cells in the blastodermic vesicle, which will develop into the trophoblast layer and then contact the endometrium and take part in establishing the embryo's means of nutrition." [MP:0005028] subset: early_development subset: pheno_slim xref: BTO:0001840 xref: EHDAA2:0002091 xref: EHDAA:56 xref: EMAPA:16046 xref: VHOG:0000979 is_a: BFO:0000002 is_a: UBERON:0000490 {source="EHDAA2"} ! unilaminar epithelium is_a: UBERON:0005292 ! extraembryonic tissue relationship: BFO:0000050 UBERON:0005631 {source="EHDAA2"} ! part of extraembryonic membrane relationship: BFO:0000051 CL:1000274 ! has part trophectodermal cell relationship: RO:0002202 UBERON:0000085 {source="EHDAA2"} ! develops from morula property_value: IAO:0000116 "distinction between trophectoderm and trophoblast unclear/inconsistent in many sources" xsd:string property_value: skos:prefLabel "trophectoderm" xsd:string [Term] id: UBERON:0004347 name: limb bud def: "An outgrowth on the lateral trunk of the embryo that develops into a limb. The limb bud is divided into ectoderm and mesenchyme[cjm, modified from MP]." [https://orcid.org/0000-0002-6601-2165, ISBN:9780878932504, MP:0005650, Wikipedia:Limb_bud] comment: developmentally_induced_by Fgf10, capable of initiating limb forming interactions between endoderm and mesoderm subset: pheno_slim synonym: "gemmae membrorum" RELATED OMO:0003011 [Wikipedia:Limb_bud] synonym: "limb buds" EXACT OMO:0003004 [] synonym: "limbbud" EXACT [GO:0060174] xref: AAO:0010375 xref: BTO:0001640 xref: EMAPA:35944 xref: FMA:296780 xref: GAID:1307 xref: MESH:D018878 xref: NCIT:C34203 xref: UMLS:C0282505 {source="ncithesaurus:Limb_Bud"} xref: Wikipedia:Limb_bud xref: XAO:0003161 is_a: UBERON:0004357 ! paired limb/fin bud relationship: RO:0002254 UBERON:0005733 ! has developmental contribution from limb field relationship: RO:0002256 UBERON:0003081 {source="ISBN:9780878932504"} ! developmentally induced by lateral plate mesoderm relationship: RO:0002387 UBERON:0002101 ! has potential to develop into limb [Term] id: UBERON:0004348 name: optic eminence def: "The embryonic structure that gives rise to the corneal ectoderm." [MP:0006305] subset: pheno_slim xref: EHDAA:938 xref: EMAPA:16322 xref: RETIRED_EHDAA2:0001308 xref: VHOG:0001296 is_a: UBERON:0006598 ! presumptive structure relationship: RO:0002387 UBERON:0000964 ! has potential to develop into cornea property_value: skos:prefLabel "optic eminence" xsd:string [Term] id: UBERON:0004356 name: apical ectodermal ridge def: "Multilayered ectodermal region at the distal tip of a limb or fin bud necessary for the proper development of the underlying mesenchyme[MP,modified]. Along with the zone of polarizing activity, it is a crucial organizing region during limb development[WP]." [MP:0001676, Wikipedia:Apical_ectodermal_ridge] subset: pheno_slim synonym: "AER" RELATED [MP:0001676] synonym: "apical epidermal ridge" EXACT [XAO:0004121] synonym: "crista ectodermalis apicalis" RELATED OMO:0003011 [Wikipedia:Apical_ectodermal_ridge] xref: AAO:0010760 xref: EMAPA:32744 xref: NCIT:C34109 xref: TAO:0002146 xref: UMLS:C1516037 {source="ncithesaurus:Apical_Ectodermal_Ridge"} xref: Wikipedia:Apical_ectodermal_ridge xref: XAO:0004121 xref: ZFA:0001702 is_a: BFO:0000002 is_a: UBERON:0002050 ! embryonic structure relationship: BFO:0000050 UBERON:0000924 ! part of ectoderm relationship: BFO:0000050 UBERON:0004357 ! part of paired limb/fin bud relationship: RO:0002215 GO:0010464 ! capable of regulation of mesenchymal cell proliferation relationship: RO:0002215 GO:0061037 ! capable of negative regulation of cartilage development relationship: RO:0002256 UBERON:0003104 ! developmentally induced by mesenchyme relationship: RO:0003000 PR:000007499 ! produces fibroblast growth factor 8 property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/5/56/Limbbuddiagram.jpg" xsd:anyURI property_value: skos:prefLabel "apical ectodermal ridge" xsd:string [Term] id: UBERON:0004357 name: paired limb/fin bud def: "An outgrowth on the lateral trunk of the embryo that develops into a limb or paired fin. The limb/fin bud is divided into ectoderm and mesenchyme[cjm, modified from MP]." [https://orcid.org/0000-0002-6601-2165, ISBN:9780878932504, MP:0005650] comment: Genes: In limb buds of chick and mouse, Shh expression is activated as soon as there is a morphological bud, whereas in S. canicula fin buds, consistent with reported data in other cartilaginous fishes, Shh is transcribed late in fin development[PMID:17187056] subset: homology_grouping synonym: "limb - fin bud" EXACT [VHOG:0001258] synonym: "paired appendage bud" EXACT [] synonym: "paired limb/fin bud" EXACT [VHOG:0001258] xref: VHOG:0001258 is_a: BFO:0000002 is_a: UBERON:0003102 ! surface structure is_a: UBERON:0006598 ! presumptive structure relationship: BFO:0000051 UBERON:0004356 ! has part apical ectodermal ridge relationship: RO:0002254 UBERON:0005732 ! has developmental contribution from paired limb/fin field relationship: RO:0002387 UBERON:0004708 ! has potential to develop into paired limb/fin property_value: skos:prefLabel "paired limb/fin bud" xsd:string [Term] id: UBERON:0004362 name: pharyngeal arch 1 def: "The first of the series of pharyngeal arches that develop into jaw bones or their homologs, and their associated nerves and arteries." [http://orcid.org/0000-0002-6601-2165] subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "1st arch" RELATED [EHDAA2:0000006] synonym: "1st pharyngeal arch" EXACT [] synonym: "1st visceral arch" RELATED [VHOG:0000296] synonym: "arcus pharyngeus primus" RELATED OMO:0003011 [Wikipedia:First_pharyngeal_arch] synonym: "branchial arch 1" EXACT SENSU [] synonym: "first branchial arch" EXACT SENSU [] synonym: "first pharyngeal arch" EXACT [] synonym: "first visceral arch" EXACT SENSU [] synonym: "mandibular arch" EXACT [] synonym: "visceral arch 1" EXACT SENSU [] xref: AAO:0010364 xref: CALOHA:TS-2089 xref: EHDAA2:0000006 xref: EHDAA:573 xref: EMAPA:16118 xref: FMA:293019 xref: MFMO:0000095 xref: NCIT:C34175 xref: SCTID:308767008 xref: TAO:0001595 xref: UMLS:C1517197 {source="ncithesaurus:First_Pharyngeal_Arch"} xref: VHOG:0000296 xref: Wikipedia:First_pharyngeal_arch xref: XAO:0000097 xref: ZFA:0001612 is_a: UBERON:0002539 ! pharyngeal arch property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/2/2d/Gray48.png" xsd:anyURI property_value: skos:prefLabel "pharyngeal arch 1" xsd:string [Term] id: UBERON:0004363 name: pharyngeal arch artery def: "One of a series of paired embryological vascular structures formed within a pharyngeal arch; in the adult, some of these vessels give rise to the great vessels[MP]." [MP:0002672] subset: efo_slim subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "a. arcuum pharyngeorum" RELATED OMO:0003011 [Wikipedia:Aortic_arches] synonym: "aortic arch" EXACT [ZFA:0005004] synonym: "aortic arch artery" RELATED [EMAPA:16684] synonym: "aortic arches" EXACT OMO:0003004 [ZFA:0005004] synonym: "arteriae arcuum pharyngeorum" RELATED OMO:0003011 [Wikipedia:Aortic_arches] synonym: "branchial aortic arches" EXACT OMO:0003004 [ZFIN:ZDB-PUB-080512-6] synonym: "branchial aortic arches" RELATED OMO:0003004 [ZFA:0005004, ZFIN:ZDB-PUB-080512-6] synonym: "branchial arch artery" EXACT [EMAPA:16684] synonym: "embryonic aortic arch artery" EXACT [EMAPA:16684, MP:0002672] synonym: "PAA" EXACT OMO:0003000 [MP:0002672] synonym: "pharyngeal arch arteries" RELATED OMO:0003004 [] synonym: "pharyngeal arch artery" EXACT [MP:0002672] synonym: "pharyngeal arch artery" RELATED [VHOG:0000122] xref: AAO:0010414 xref: EFO:0003695 xref: EHDAA2:0000186 xref: EHDAA:398 xref: EHDAA:7327 xref: EMAPA:16684 xref: NCIT:C32123 xref: TAO:0005004 xref: UMLS:C0003489 {source="ncithesaurus:Aortic_Arch"} xref: VHOG:0000122 xref: Wikipedia:Aortic_arches xref: XAO:0000341 xref: ZFA:0005004 is_a: UBERON:0003469 ! respiratory system artery is_a: UBERON:0006598 ! presumptive structure is_a: UBERON:0010314 ! structure with developmental contribution from neural crest relationship: BFO:0000050 UBERON:0002539 ! part of pharyngeal arch relationship: BFO:0000050 UBERON:0007303 {source="ZFA"} ! part of pharyngeal vasculature relationship: RO:0002387 UBERON:0001637 ! has potential to develop into artery relationship: RO:0002433 UBERON:0002539 ! contributes to morphology of pharyngeal arch property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/8/84/Gray473.png" xsd:anyURI property_value: IAO:0000116 "add specific artery derivatives" xsd:string property_value: skos:prefLabel "pharyngeal arch artery" xsd:string [Term] id: UBERON:0004364 name: ectoplacental cone def: "Thickened trophoblast of the blastocyst in rodents that becomes the fetal portion of the placenta." [MP:0001717, PMID:19829370] subset: pheno_slim synonym: "epamniotic cone" EXACT [] synonym: "placenta - ectoplacental cone" EXACT [] xref: BTO:0001715 xref: EMAPA:16059 is_a: UBERON:0002050 ! embryonic structure relationship: BFO:0000050 UBERON:0000088 ! part of trophoblast [Term] id: UBERON:0004365 name: vitelline blood vessel def: "Blood vessel that is connected to the yolk sac." [http://orcid.org/0000-0002-6601-2165] subset: pheno_slim xref: EMAPA:36494 is_a: UBERON:0001981 ! blood vessel intersection_of: UBERON:0001981 ! blood vessel intersection_of: RO:0002170 UBERON:0001040 ! connected to yolk sac relationship: BFO:0000050 UBERON:0004374 ! part of vitelline vasculature relationship: RO:0002170 UBERON:0001040 ! connected to yolk sac property_value: skos:prefLabel "vitelline blood vessel" xsd:string [Term] id: UBERON:0004367 name: Descemet's membrane def: "A transparent homogeneous acellular layer found between the substantia propria and the endothelial layer of the cornea[MP]." [https://github.com/obophenotype/uberon/issues/15, MP:0004285] comment: The strong, resistant, thin, noncellular fourth layer of the cornea, located between the endothelium (from which it is secreted) and the stroma. (Cline et al., Dictionary of Visual Science, 4th ed) subset: pheno_slim subset: vertebrate_core synonym: "Descemet membrane" EXACT [] synonym: "Descemet's posterior elastic lamina" EXACT [FMA:58309] synonym: "lamina limitans posterior" EXACT [FMA:58309] synonym: "lamina limitans posterior corneae" EXACT OMO:0003011 [FMA:58309, FMA:TA] synonym: "posterior limiting lamina" EXACT [MA:0001246] synonym: "posterior limiting lamina of cornea" EXACT [FMA:58309] synonym: "posterior limiting membrane" EXACT [ZFA:0001686] xref: EMAPA:18804 xref: FMA:58309 xref: GAID:894 xref: MA:0001246 xref: MESH:D003886 xref: NCIT:C32454 xref: SCTID:281076002 xref: TAO:0002157 xref: UMLS:C0011665 {source="ncithesaurus:Descemet_s_Membrane"} xref: Wikipedia:Descemet%27s_membrane xref: ZFA:0001686 is_a: UBERON:0005769 ! basement membrane of epithelium intersection_of: UBERON:0005769 ! basement membrane of epithelium intersection_of: BFO:0000050 UBERON:0000964 ! part of cornea intersection_of: RO:0002220 UBERON:0001777 ! adjacent to substantia propria of cornea intersection_of: RO:0002220 UBERON:0001985 ! adjacent to corneal endothelium disjoint_from: UBERON:0004370 {source="lexical"} ! anterior limiting lamina of cornea relationship: BFO:0000050 UBERON:0000964 ! part of cornea relationship: RO:0000086 PATO:0000964 ! has quality transparent relationship: RO:0002220 UBERON:0001777 ! adjacent to substantia propria of cornea relationship: RO:0002220 UBERON:0001985 ! adjacent to corneal endothelium relationship: RO:0003001 UBERON:0001985 {source="Cline et al"} ! produced by corneal endothelium property_value: seeAlso "https://github.com/obophenotype/uberon/issues/15" xsd:anyURI property_value: terms:contributor https://orcid.org/0000-0002-2061-091X property_value: terms:contributor https://orcid.org/0000-0002-6601-2165 [Term] id: UBERON:0004370 name: anterior limiting lamina of cornea def: "A transparent homogeneous acellular layer, 6 to 9 um thick, lying between the basal lamina of the outer layer of stratified epithelium and the substantia propria of the cornea; it is considered to be a basement membrane." [ncithesaurus:Bowman_s_Membrane] subset: pheno_slim subset: vertebrate_core synonym: "anterior elastic lamina" EXACT [ZFA:0001684] synonym: "anterior limiting lamina" EXACT [MA:0001240] synonym: "anterior limiting lamina of cornea" EXACT [FMA:58273] synonym: "anterior limiting membrane" RELATED [ZFA:0001684] synonym: "Bowman's anterior elastic lamina" EXACT [FMA:58273] synonym: "Bowman's layer" EXACT [FMA:58273] synonym: "Bowman's membrane" EXACT [FMA:58273] synonym: "lamina limitans anterior (cornea)" EXACT [FMA:58273] synonym: "lamina limitans anterior corneae" EXACT OMO:0003011 [FMA:58273, FMA:TA] synonym: "Reichert's membrane" RELATED OMO:0003002 [http://sourceforge.net/tracker/?func=detail&aid=2956371&group_id=76834&atid=974957] xref: FMA:58273 xref: MA:0001240 xref: NCIT:C32226 xref: SCTID:281075003 xref: TAO:0002155 xref: UMLS:C0229127 {source="ncithesaurus:Bowman_s_Membrane"} xref: Wikipedia:Bowman%27s_membrane xref: ZFA:0001684 is_a: UBERON:0005769 ! basement membrane of epithelium intersection_of: UBERON:0005769 ! basement membrane of epithelium intersection_of: BFO:0000050 UBERON:0000964 ! part of cornea intersection_of: RO:0002371 UBERON:0001772 ! attached to corneal epithelium relationship: BFO:0000050 UBERON:0000964 ! part of cornea relationship: RO:0002371 UBERON:0001772 ! attached to corneal epithelium property_value: skos:prefLabel "anterior limiting lamina of cornea" xsd:string [Term] id: UBERON:0004374 name: vitelline vasculature def: "Vascular network that is connected to the yolk sac." [http://orcid.org/0000-0002-6601-2165] subset: pheno_slim synonym: "omphalomesenteric system" RELATED [https://orcid.org/0000-0002-6601-2165] synonym: "vitelline bloos vessel system" RELATED [https://orcid.org/0000-0002-6601-2165] synonym: "vitelline system" RELATED [https://orcid.org/0000-0002-6601-2165] xref: Wikipedia:Vitelline_circulation is_a: UBERON:0002049 ! vasculature intersection_of: UBERON:0002049 ! vasculature intersection_of: RO:0002170 UBERON:0001040 ! connected to yolk sac relationship: RO:0002170 UBERON:0001040 ! connected to yolk sac property_value: skos:prefLabel "vitelline vasculature" xsd:string [Term] id: UBERON:0004375 name: bone of free limb or fin def: "A bone that is part of an appendage [Automatically generated definition]." [OBOL:automatic] subset: homology_grouping synonym: "appendage bone" EXACT [] synonym: "bone of appendage" EXACT [] synonym: "bone of free segment of appendicular skeleton" EXACT [] is_a: UBERON:0010740 ! bone of appendage girdle complex intersection_of: UBERON:0001474 ! bone element intersection_of: BFO:0000050 UBERON:0004708 ! part of paired limb/fin relationship: BFO:0000050 UBERON:0011582 ! part of paired limb/fin skeleton property_value: skos:prefLabel "bone of free limb or fin" xsd:string [Term] id: UBERON:0004378 name: proximal metaphysis def: "A metaphysis that is in the proximal side of a diaphysis." [OBOL:automatic] synonym: "proximal diaphyseal end of long bone" EXACT [FMA:32823] xref: FMA:32823 is_a: UBERON:0001438 ! metaphysis intersection_of: UBERON:0001438 ! metaphysis intersection_of: BSPO:0000124 UBERON:0004769 ! diaphysis relationship: BSPO:0000124 UBERON:0004769 ! diaphysis [Term] id: UBERON:0004380 name: proximal epiphysis def: "An epiphysis that is on the proximal side of the bone." [http://orcid.org/0000-0002-6601-2165] synonym: "proximal end of long bone" EXACT [FMA:32821] xref: FMA:32821 xref: SCTID:279998003 is_a: UBERON:0001437 ! epiphysis intersection_of: UBERON:0001437 ! epiphysis intersection_of: BSPO:0000124 UBERON:0001474 ! bone element relationship: BSPO:0000124 UBERON:0001474 ! bone element relationship: RO:0002220 UBERON:0004378 ! adjacent to proximal metaphysis [Term] id: UBERON:0004381 name: skeleton of limb def: "The collection of all skeletal elements in an individual limb." [https://orcid.org/0000-0002-6601-2165] synonym: "free limb skeleton" EXACT [VSAO:0000300] synonym: "limb skeleton" EXACT [EHDAA2:0002221] synonym: "set of bones of limb" EXACT [] xref: EHDAA2:0002221 xref: EMAPA:32702 xref: VSAO:0000300 is_a: UBERON:0010712 ! limb skeleton subdivision is_a: UBERON:0011582 ! paired limb/fin skeleton intersection_of: UBERON:0010912 ! subdivision of skeleton intersection_of: RO:0002576 UBERON:0002101 ! skeleton of limb relationship: RO:0002576 UBERON:0002101 ! skeleton of limb [Term] id: UBERON:0004382 name: epiphysis of humerus def: "An epiphysis that is part of a humerus [Automatically generated definition]." [OBOL:automatic] subset: pheno_slim synonym: "humeral epiphysis" EXACT [OBOL:automatic] xref: FMA:32825 xref: SCTID:313054009 is_a: UBERON:0001437 ! epiphysis intersection_of: UBERON:0001437 ! epiphysis intersection_of: BFO:0000050 UBERON:0000976 ! part of humerus relationship: BFO:0000050 UBERON:0000976 ! part of humerus [Term] id: UBERON:0004383 name: epiphysis of tibia def: "An epiphysis that is part of a tibia [Automatically generated definition]." [OBOL:automatic] subset: pheno_slim synonym: "tibial epiphysis" EXACT [FMA:33112] xref: EMAPA:37771 {source="MA:th"} xref: FMA:33112 xref: MA:0003113 xref: SCTID:314626006 is_a: UBERON:0001437 ! epiphysis intersection_of: UBERON:0001437 ! epiphysis intersection_of: BFO:0000050 UBERON:0000979 ! part of tibia relationship: BFO:0000050 UBERON:0000979 ! part of tibia [Term] id: UBERON:0004384 name: epiphysis of femur def: "An epiphysis that is part of a femur [Automatically generated definition]." [OBOL:automatic] subset: pheno_slim synonym: "femoral epiphysis" EXACT [FMA:32838] xref: EMAPA:37539 {source="MA:th"} xref: FMA:32838 xref: MA:0003056 xref: SCTID:314625005 is_a: UBERON:0001437 ! epiphysis intersection_of: UBERON:0001437 ! epiphysis intersection_of: BFO:0000050 UBERON:0000981 ! part of femur relationship: BFO:0000050 UBERON:0000981 ! part of femur [Term] id: UBERON:0004387 name: epiphysis of phalanx of manus def: "An epiphysis that is part of a phalanx of a manus [Automatically generated definition]." [OBOL:automatic] subset: pheno_slim synonym: "epiphysis of phalanx of finger" EXACT [] synonym: "epiphysis of phalanx of hand" RELATED [FMA:240707] xref: FMA:240707 xref: SCTID:314620000 is_a: UBERON:0004446 ! epiphysis of phalanx intersection_of: UBERON:0001437 ! epiphysis intersection_of: BFO:0000050 UBERON:0001436 ! part of phalanx of manus relationship: BFO:0000050 UBERON:0001436 ! part of phalanx of manus [Term] id: UBERON:0004388 name: epiphysis of fibula def: "An epiphysis that is part of a fibula [Automatically generated definition]." [OBOL:automatic] subset: pheno_slim synonym: "fibula epiphysis" EXACT [FMA:33726] xref: FMA:33726 is_a: UBERON:0001437 ! epiphysis intersection_of: UBERON:0001437 ! epiphysis intersection_of: BFO:0000050 UBERON:0001446 ! part of fibula relationship: BFO:0000050 UBERON:0001446 ! part of fibula [Term] id: UBERON:0004389 name: epiphysis of metatarsal bone def: "An epiphysis that is part of a metatarsal bone [Automatically generated definition]." [OBOL:automatic] subset: pheno_slim synonym: "epiphysis of metatarsal" EXACT [] synonym: "metatarsal bone epiphysis" EXACT [FMA:33814] synonym: "metatarsal epiphysis" EXACT [] xref: FMA:33814 xref: SCTID:313057002 is_a: UBERON:0011973 ! epiphysis of phalanx of pes intersection_of: UBERON:0001437 ! epiphysis intersection_of: BFO:0000050 UBERON:0001448 ! part of metatarsal bone relationship: BFO:0000050 UBERON:0001448 ! part of metatarsal bone [Term] id: UBERON:0004390 name: epiphysis of metacarpal bone def: "An epiphysis that is part of a metacarpal bone [Automatically generated definition]." [OBOL:automatic] subset: pheno_slim synonym: "epiphysis of metacarpal" EXACT [] synonym: "metacarpal bone epiphysis" EXACT [FMA:33792] synonym: "metacarpal epiphysis" EXACT [] xref: FMA:33792 xref: SCTID:314907001 is_a: UBERON:0001437 ! epiphysis intersection_of: UBERON:0001437 ! epiphysis intersection_of: BFO:0000050 UBERON:0002374 ! part of metacarpal bone relationship: BFO:0000050 UBERON:0002374 ! part of metacarpal bone [Term] id: UBERON:0004400 name: bone tissue of epiphysis def: "A portion of bone tissue that is part of a epiphysis [Automatically generated definition]." [OBOL:automatic] xref: FMA:241364 is_a: UBERON:0005808 ! bone tissue of long bone intersection_of: UBERON:0002481 ! bone tissue intersection_of: BFO:0000050 UBERON:0001437 ! part of epiphysis relationship: BFO:0000050 UBERON:0001437 ! part of epiphysis [Term] id: UBERON:0004402 name: bone tissue of proximal epiphysis def: "A portion of bone tissue that is part of a proximal epiphysis [Automatically generated definition]." [OBOL:automatic] xref: FMA:241372 is_a: UBERON:0004400 ! bone tissue of epiphysis intersection_of: UBERON:0002481 ! bone tissue intersection_of: BFO:0000050 UBERON:0004380 ! part of proximal epiphysis relationship: BFO:0000050 UBERON:0004380 ! part of proximal epiphysis [Term] id: UBERON:0004403 name: periosteum of epiphysis def: "A periosteum that is part of a epiphysis [Automatically generated definition]." [OBOL:automatic] synonym: "epiphysis periosteum" EXACT [FMA:32687] xref: FMA:32687 is_a: UBERON:0016896 ! periosteum of long bone intersection_of: UBERON:0002515 ! periosteum intersection_of: BFO:0000050 UBERON:0001437 ! part of epiphysis relationship: BFO:0000050 UBERON:0001437 ! part of epiphysis [Term] id: UBERON:0004411 name: proximal epiphysis of humerus def: "The upper extremity of the humerus (proximal humerus) consists of a large rounded head joined to the body by a constricted portion called the neck, and two eminences, the greater and lesser tubercles." [Wikipedia:Upper_extremity_of_humerus] subset: pheno_slim synonym: "head of the humerus" RELATED [Wikipedia:Upper_extremity_of_humerus] synonym: "humeral head" RELATED [Wikipedia:Upper_extremity_of_humerus] synonym: "proximal end of humerus" EXACT [FMA:23362] synonym: "proximal humeral epiphysis" EXACT [https://orcid.org/0000-0002-6601-2165, OBOL:automatic] synonym: "proximal humerus" RELATED [Wikipedia:Upper_extremity_of_humerus] synonym: "upper end of humerus" EXACT [FMA:23362] synonym: "upper extremity of humerus" RELATED [Wikipedia:Upper_extremity_of_humerus] xref: FMA:23362 xref: SCTID:280028008 xref: Wikipedia:Upper_extremity_of_humerus is_a: UBERON:0004380 ! proximal epiphysis is_a: UBERON:0004382 ! epiphysis of humerus intersection_of: UBERON:0004380 ! proximal epiphysis intersection_of: BFO:0000050 UBERON:0000976 ! part of humerus property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/a/ad/Gray207.png" xsd:anyURI [Term] id: UBERON:0004412 name: proximal epiphysis of femur def: "A proximal epiphysis that is part of a femur [Automatically generated definition]." [OBOL:automatic] subset: pheno_slim synonym: "capital femoral epiphysis" RELATED [http://orcid.org/0000-0002-6601-2165] synonym: "proximal femoral epiphysis" EXACT [https://orcid.org/0000-0002-6601-2165, OBOL:automatic] xref: FMA:32841 xref: SCTID:244702009 is_a: UBERON:0004380 ! proximal epiphysis is_a: UBERON:0004384 ! epiphysis of femur intersection_of: UBERON:0004380 ! proximal epiphysis intersection_of: BFO:0000050 UBERON:0000981 ! part of femur [Term] id: UBERON:0004414 name: proximal epiphysis of phalanx of manus def: "A proximal epiphysis that is part of a phalanx of manus [Automatically generated definition]." [OBOL:automatic] synonym: "basal epiphysis of phalanx of finger" EXACT [FMA:226482] synonym: "base of phalanx of finger" EXACT [FMA:226482] synonym: "basis phalangis manus" EXACT OMO:0003011 [FMA:226482, FMA:TA] synonym: "proximal epiphysis of phalanx of finger" EXACT [] synonym: "proximal epiphysis of phalanx of hand" RELATED [FMA:226482] xref: FMA:226482 xref: SCTID:272704004 is_a: UBERON:0004387 ! epiphysis of phalanx of manus is_a: UBERON:0004447 ! proximal epiphysis of phalanx intersection_of: UBERON:0004380 ! proximal epiphysis intersection_of: BFO:0000050 UBERON:0001436 ! part of phalanx of manus [Term] id: UBERON:0004415 name: proximal epiphysis of metatarsal bone def: "A proximal epiphysis that is part of a metatarsal bone [Automatically generated definition]." [OBOL:automatic] synonym: "base of metatarsal bone" EXACT [FMA:33817] synonym: "basis ossis metatarsi" EXACT OMO:0003011 [FMA:33817, FMA:TA] synonym: "proximal end of metatarsal bone" EXACT [FMA:33817] synonym: "upper end of metatarsal bone" EXACT [FMA:33817] xref: FMA:33817 xref: SCTID:119545008 is_a: UBERON:0004380 ! proximal epiphysis is_a: UBERON:0004389 ! epiphysis of metatarsal bone intersection_of: UBERON:0004380 ! proximal epiphysis intersection_of: BFO:0000050 UBERON:0001448 ! part of metatarsal bone [Term] id: UBERON:0004416 name: proximal epiphysis of metacarpal bone def: "A proximal epiphysis that is part of a metacarpal bone [Automatically generated definition]." [OBOL:automatic] synonym: "base of metacarpal bone" EXACT [FMA:33795] synonym: "basis ossis metacarpi" EXACT OMO:0003011 [FMA:33795, FMA:TA] synonym: "metacarpal bone base" EXACT [FMA:33795] synonym: "proximal end of metacarpal bone" EXACT [FMA:33795] synonym: "upper end of metacarpal bone" EXACT [FMA:33795] xref: FMA:33795 xref: SCTID:272695001 is_a: UBERON:0004380 ! proximal epiphysis is_a: UBERON:0004390 ! epiphysis of metacarpal bone intersection_of: UBERON:0004380 ! proximal epiphysis intersection_of: BFO:0000050 UBERON:0002374 ! part of metacarpal bone [Term] id: UBERON:0004446 name: epiphysis of phalanx def: "An epiphysis that is part of a phalanx [Automatically generated definition]." [OBOL:automatic] subset: pheno_slim xref: SCTID:280033007 is_a: UBERON:0001437 ! epiphysis intersection_of: UBERON:0001437 ! epiphysis intersection_of: BFO:0000050 UBERON:0003221 ! part of phalanx relationship: BFO:0000050 UBERON:0003221 ! part of phalanx [Term] id: UBERON:0004447 name: proximal epiphysis of phalanx def: "A proximal epiphysis that is part of a phalanx [Automatically generated definition]." [OBOL:automatic] is_a: UBERON:0004380 ! proximal epiphysis is_a: UBERON:0004446 ! epiphysis of phalanx intersection_of: UBERON:0004380 ! proximal epiphysis intersection_of: BFO:0000050 UBERON:0003221 ! part of phalanx [Term] id: UBERON:0004449 name: cerebral artery def: "One of three main pairs of arteries and their branches, which irrigate the cerebrum of the brain." [Wikipedia:Cerebral_artery] subset: pheno_slim xref: AAO:0010493 xref: BTO:0005205 xref: CALOHA:TS-0126 xref: EHDAA2:0000233 xref: EHDAA:5294 xref: EMAPA:18613 xref: GAID:484 xref: MA:0002562 xref: MESH:D002536 xref: NCIT:C12691 xref: SCTID:181308008 xref: UMLS:C0007770 {source="ncithesaurus:Cerebral_Artery"} xref: Wikipedia:Cerebral_artery xref: XAO:0000367 is_a: UBERON:0004573 ! systemic artery intersection_of: UBERON:0001637 ! artery intersection_of: RO:0020101 UBERON:0001893 ! vessel supplies blood to telencephalon relationship: BFO:0000050 UBERON:0003709 ! part of circle of Willis relationship: RO:0020101 UBERON:0001893 ! vessel supplies blood to telencephalon property_value: skos:prefLabel "cerebral artery" xsd:string [Term] id: UBERON:0004451 name: trunk or cervical vertebra def: "A vertebra in the trunk or cervical region. Includes all cervical, thoracic and lumbar vertebrae, but excludes caudal vertebra." [UBERONREF:0000006] subset: pheno_slim synonym: "presacral vertebra" RELATED [MA:0002869] xref: EMAPA:37722 {source="MA:th"} xref: MA:0002869 xref: XAO:0003077 is_a: UBERON:0002412 ! vertebra is_a: UBERON:0004247 ! bone of dorsum intersection_of: UBERON:0002412 ! vertebra intersection_of: BSPO:0000096 UBERON:0001095 ! caudal vertebra union_of: UBERON:0002413 ! cervical vertebra union_of: UBERON:0011677 ! trunk vertebra relationship: BSPO:0000096 UBERON:0001095 ! caudal vertebra property_value: skos:prefLabel "trunk or cervical vertebra" xsd:string [Term] id: UBERON:0004452 name: carpal region def: "A mesopodium that is part of a manus. Includes as parts the carpal skeleton and associated tissues[cjm]. The anatomical region surrounding the carpus including the distal parts of the bones of the forearm and the proximal parts of the metacarpus or five metacarpal bones and the series of joints between these bones, thus referred to as wrist joints. This region also includes the carpal tunnel, the anatomical snuff box, the flexor retinaculum, and the extensor retinaculum[WP,unvetted]." [https://orcid.org/0000-0002-6601-2165, Wikipedia:Wrist] subset: pheno_slim subset: uberon_slim synonym: "articulatio radiocarpea" RELATED OMO:0003011 [Wikipedia:Wrist] synonym: "carpal limb segment" EXACT [] synonym: "carpal segment" EXACT [] synonym: "carpus" RELATED INCONSISTENT [] synonym: "carpus of fore-paw" NARROW [EMAPA:19122] synonym: "fore basipodium" EXACT [MA:th] synonym: "fore mesopodium" EXACT [MA:th] synonym: "hand mesopodium" EXACT [] synonym: "manus mesopodium" EXACT [] synonym: "regio carpalis" EXACT OMO:0003011 [FMA:24922, FMA:TA] synonym: "wrist" EXACT [MA:0000039] synonym: "wrist region" EXACT [] xref: EHDAA2:0000218 xref: EHDAA:5196 xref: EMAPA:19122 xref: EMAPA:32784 xref: FMA:24922 xref: GAID:59 xref: galen:Wrist xref: MA:0000039 xref: MESH:D014953 xref: NCIT:C111033 xref: SCTID:361289009 xref: Wikipedia:Wrist is_a: UBERON:0006716 ! mesopodium region is_a: UBERON:0008785 {source="FMA"} ! upper limb segment intersection_of: UBERON:0006716 ! mesopodium region intersection_of: BFO:0000050 UBERON:0002398 ! part of manus relationship: BFO:0000050 UBERON:0002398 ! part of manus relationship: distally_connected_to UBERON:0004453 ! metacarpus region relationship: proximally_connected_to UBERON:0002386 ! forelimb zeugopod relationship: RO:0002551 UBERON:0009880 ! has skeleton carpal skeleton property_value: foaf:depiction "https://upload.wikimedia.org/wikipedia/commons/4/4a/Human_wrist.png" xsd:anyURI property_value: foaf:depiction "https://upload.wikimedia.org/wikipedia/commons/c/cc/Hand_parts.jpg" xsd:anyURI [Term] id: UBERON:0004453 name: metacarpus region def: "A metapodium region that is part of a manus." [OBOL:automatic] subset: pheno_slim synonym: "distal segment of hand proper" EXACT [FMA:24925] synonym: "forelimb cannon region" NARROW [http://orcid.org/0000-0002-6601-2165, NCBITaxon:9788] synonym: "forelimb equine cannon region" NARROW [http://orcid.org/0000-0002-6601-2165, NCBITaxon:9788] synonym: "metacarpal part of hand" EXACT [FMA:24925] synonym: "metacarpal part of manus" EXACT [] synonym: "metacarpal region" EXACT [FMA:24925] synonym: "metacarpus" EXACT [MA:0000042] xref: CALOHA:TS-2218 xref: EMAPA:32654 xref: FMA:24925 xref: MA:0000042 xref: SCTID:370638006 is_a: UBERON:0005451 {source="FMA"} ! segment of manus is_a: UBERON:0009877 ! metapodium region intersection_of: UBERON:0009877 ! metapodium region intersection_of: BFO:0000050 UBERON:0002398 ! part of manus relationship: BFO:0000050 UBERON:0012141 {source="PHENOSCAPE:ni"} ! part of manual digitopodium region relationship: RO:0002551 UBERON:0010544 ! has skeleton metacarpus skeleton property_value: foaf:depiction "https://upload.wikimedia.org/wikipedia/commons/2/2f/Metacarpals_numbered-en.svg" xsd:anyURI property_value: IAO:0000116 "Note that along with FMA we treat this as a limb segment rather than a purely skeletal element" xsd:string [Term] id: UBERON:0004454 name: tarsal region def: "Mesopodial segment of the pes, including the tarsal skeleton and associated tissues." [https://orcid.org/0000-0002-6601-2165, Wikipedia:Ankle] subset: efo_slim subset: pheno_slim subset: uberon_slim synonym: "ankle" EXACT [MA:0000043] synonym: "ankle region" EXACT [] synonym: "articulatio talocruralis" RELATED OMO:0003011 [Wikipedia:Ankle] synonym: "hind basipodium" RELATED [MA:th] synonym: "hind mesopodium" RELATED [MA:th] synonym: "hock" RELATED SENSU [Wikipedia:Hock_(anatomy)] synonym: "tarsal limb segment" EXACT [] xref: CALOHA:TS-2219 xref: EFO:0001409 xref: EMAPA:32783 xref: FMA:9665 xref: GAID:41 xref: galen:Ankle xref: MA:0000043 xref: MESH:D000842 xref: SCTID:361292008 xref: Wikipedia:Ankle is_a: UBERON:0006716 ! mesopodium region is_a: UBERON:0008784 ! lower limb segment intersection_of: UBERON:0006716 ! mesopodium region intersection_of: BFO:0000050 UBERON:0002387 ! part of pes relationship: BFO:0000050 UBERON:0002387 ! part of pes relationship: distally_connected_to UBERON:0000983 ! metatarsus region relationship: proximally_connected_to UBERON:0003823 ! hindlimb zeugopod relationship: RO:0002551 UBERON:0009879 ! has skeleton tarsal skeleton property_value: foaf:depiction "https://upload.wikimedia.org/wikipedia/commons/b/bf/Ankle_en.svg" xsd:anyURI [Term] id: UBERON:0004455 name: neurula embryo def: "An embryo at the neurula stage." [http://orcid.org/0000-0002-6601-2165] synonym: "neurula" EXACT [BTO:0001766] xref: BILA:0000061 xref: BTO:0001766 xref: NCIT:C34229 xref: UMLS:C1518306 {source="ncithesaurus:Neurula"} is_a: BFO:0000002 is_a: UBERON:0000922 ! embryo intersection_of: UBERON:0000468 ! multicellular organism intersection_of: RO:0002491 UBERON:0000110 ! existence starts and ends during neurula stage relationship: RO:0002202 UBERON:0004734 ! develops from gastrula relationship: RO:0002491 UBERON:0000110 ! existence starts and ends during neurula stage property_value: skos:prefLabel "neurula embryo" xsd:string [Term] id: UBERON:0004456 name: entire sense organ system def: "Sum of all sensory systems in an organism." [http://orcid.org/0000-0002-6601-2165] subset: human_reference_atlas subset: uberon_slim synonym: "sense organ system" EXACT [FMA:78499] xref: FMA:78499 is_a: UBERON:0000467 ! anatomical system disjoint_from: UBERON:8450002 ! excretory system relationship: RO:0002131 UBERON:0001016 ! overlaps nervous system relationship: RO:0002492 UBERON:0000066 ! existence ends during fully formed stage property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "entire sense organ system" xsd:string [Term] id: UBERON:0004461 name: skeletal musculature of head def: "Any collection of skeletal muscles that is part of a head [Automatically generated definition]." [OBOL:automatic] comment: This class is restricted to skeletal muscles that attach to the cranial skeleton. This seems to be consistent with FMA and EMAPA usage. Note that by definition this excludes invertebrate head musculature. It corresponds to the individual muscle organ term UBERON:0002376 subset: non_informative synonym: "head musculature" EXACT [FMA:71287] synonym: "muscle group of head" EXACT [FMA:71287] synonym: "muscles of head" EXACT [FMA:71287] synonym: "musculi capitis" EXACT OMO:0003011 [FMA:71287, FMA:TA] synonym: "set of muscles of head" EXACT [FMA:71287] xref: EMAPA:18171 xref: FMA:71287 is_a: UBERON:0008229 ! craniocervical region musculature intersection_of: UBERON:0001015 ! musculature intersection_of: BFO:0000050 UBERON:0000033 ! part of head intersection_of: RO:0002371 UBERON:0003129 ! attached to skull relationship: BFO:0000050 UBERON:0000033 ! part of head relationship: BFO:0000050 UBERON:0013700 ! part of axial musculature relationship: RO:0002202 UBERON:0005253 ! develops from head mesenchyme relationship: RO:0002371 UBERON:0003129 ! attached to skull property_value: seeAlso "https://github.com/obophenotype/mouse-anatomy-ontology/issues/4" xsd:anyURI property_value: seeAlso "https://github.com/obophenotype/uberon/issues/1405" xsd:anyURI property_value: skos:prefLabel "skeletal musculature of head" xsd:string [Term] id: UBERON:0004462 name: musculature of body wall def: "Any collection of muscles that is part of a body wall [Automatically generated definition]." [OBOL:automatic] synonym: "body wall muscles" RELATED [] synonym: "body wall musculature" EXACT [FMA:86931] xref: BSA:0000058 xref: BTO:0001863 xref: EMAPA:37853 {source="MA:th"} xref: FMA:86931 xref: WBbt:0005813 is_a: UBERON:0001015 ! musculature intersection_of: UBERON:0001015 ! musculature intersection_of: BFO:0000050 UBERON:0000309 ! part of body wall relationship: BFO:0000050 UBERON:0000309 ! part of body wall [Term] id: UBERON:0004463 name: musculature of hindlimb stylopod def: "Any collection of muscles that is part of a hindlimb stylopod (upper leg / thigh)[Automatically generated definition]." [OBOL:automatic] subset: pheno_slim synonym: "muscle group of thigh" EXACT [FMA:50208] synonym: "musculature of thigh" EXACT [FMA:50208] synonym: "set of muscles of thigh" EXACT [FMA:50208] synonym: "thigh musculature" EXACT [FMA:50208] xref: FMA:50208 is_a: UBERON:0004466 ! musculature of leg intersection_of: UBERON:0001015 ! musculature intersection_of: BFO:0000050 UBERON:0000376 ! part of hindlimb stylopod relationship: BFO:0000050 UBERON:0000376 ! part of hindlimb stylopod [Term] id: UBERON:0004464 name: musculature of thorax def: "Any collection of muscles that is part of a thorax [Automatically generated definition]." [OBOL:automatic] subset: pheno_slim synonym: "muscle group of thorax" EXACT [FMA:71293] synonym: "muscles of thorax" EXACT [FMA:71293] synonym: "musculi thoracis" EXACT OMO:0003011 [FMA:71293, FMA:TA] synonym: "set of muscles of thorax" EXACT [FMA:71293] synonym: "thoracic musculature" EXACT [FMA:71293] xref: BTO:0000508 xref: EMAPA:37260 {source="MA:th"} xref: FMA:71293 is_a: UBERON:0004479 ! musculature of trunk intersection_of: UBERON:0001015 ! musculature intersection_of: BFO:0000050 UBERON:0000915 ! part of thoracic segment of trunk relationship: BFO:0000050 UBERON:0000915 ! part of thoracic segment of trunk property_value: skos:prefLabel "musculature of thorax" xsd:string [Term] id: UBERON:0004465 name: musculature of neck def: "Any collection of muscles that is part of a neck [Automatically generated definition]." [OBOL:automatic] subset: pheno_slim synonym: "cervical muscles" EXACT [AAO:0000091] synonym: "muscle group of neck" EXACT [FMA:71290] synonym: "muscles of neck" EXACT [FMA:71290] synonym: "musculi cervicis" EXACT OMO:0003011 [FMA:71290, FMA:TA] synonym: "musculi colli" EXACT OMO:0003011 [FMA:71290, FMA:TA] synonym: "neck musculature" EXACT [FMA:71290] synonym: "set of muscles of neck" EXACT [FMA:71290] xref: AAO:0000091 xref: EMAPA:36050 xref: FMA:71290 xref: MESH:D009334 is_a: UBERON:0001015 ! musculature intersection_of: UBERON:0001015 ! musculature intersection_of: BFO:0000050 UBERON:0000974 ! part of neck relationship: BFO:0000050 UBERON:0000974 ! part of neck property_value: skos:prefLabel "musculature of neck" xsd:string [Term] id: UBERON:0004466 name: musculature of leg def: "Any collection of muscles that is part of a lower leg or upper leg [Automatically generated definition]." [OBOL:automatic] synonym: "leg muscle system" EXACT [EHDAA2:0000973] xref: EHDAA2:0000973 is_a: UBERON:0004482 ! musculature of lower limb intersection_of: UBERON:0001015 ! musculature intersection_of: BFO:0000050 UBERON:0000978 ! part of leg relationship: BFO:0000050 UBERON:0000978 ! part of leg [Term] id: UBERON:0004467 name: musculature of pharynx def: "The collection of muscles that acts on the pharynx." [http://orcid.org/0000-0002-6601-2165] comment: See comments for 'pharyngeal muscle' subset: vertebrate_core synonym: "pharyngeal musculature" EXACT [TAO:0001307] synonym: "set of muscles of pharynx" RELATED [FMA:264609] xref: FMA:264609 xref: TAO:0001307 xref: ZFA:0001307 is_a: UBERON:0001015 ! musculature relationship: RO:0002131 UBERON:0001042 ! overlaps chordate pharynx [Term] id: UBERON:0004468 name: set of muscles of vertebral column synonym: "muscle group of vertebral column" EXACT [FMA:33061] xref: FMA:33061 is_a: UBERON:0001015 ! musculature intersection_of: UBERON:0001015 ! musculature intersection_of: RO:0002371 UBERON:0001130 ! attached to vertebral column relationship: RO:0002371 UBERON:0001130 ! attached to vertebral column property_value: skos:prefLabel "set of muscles of vertebral column" xsd:string [Term] id: UBERON:0004469 name: musculature of back def: "Any collection of muscles that is part of a back [Automatically generated definition]." [OBOL:automatic] synonym: "muscle group of back" EXACT [FMA:71291] synonym: "muscles of back" EXACT [FMA:71291] synonym: "musculi dorsi" EXACT OMO:0003011 [FMA:71291, FMA:TA] synonym: "set of muscles of back" EXACT [FMA:71291] xref: FMA:71291 is_a: UBERON:0001015 ! musculature intersection_of: UBERON:0001015 ! musculature intersection_of: BFO:0000050 UBERON:0001137 ! part of dorsum relationship: BFO:0000050 UBERON:0001137 ! part of dorsum property_value: skos:prefLabel "musculature of back" xsd:string [Term] id: UBERON:0004470 name: musculature of pelvic girdle def: "Any collection of muscles that is part of a pelvic girdle [Automatically generated definition]." [OBOL:automatic] subset: pheno_slim synonym: "muscle group of pelvic girdle" EXACT [FMA:50205] synonym: "muscle group of pelvis" EXACT [FMA:50248] synonym: "muscular system of pelvis" RELATED [FMA:50248] synonym: "pelvic girdle muscle system" EXACT [EHDAA2:0001429] synonym: "pelvic girdle muscles" EXACT [AAO:0000427] synonym: "pelvic girdle musculature" EXACT [FMA:50205] synonym: "set of muscles of pelvic girdle" EXACT [FMA:50205] synonym: "set of muscles of pelvis" RELATED [FMA:50248] xref: AAO:0000427 xref: EHDAA2:0001429 xref: EMAPA:18184 xref: FMA:50205 xref: FMA:50248 is_a: UBERON:0004479 ! musculature of trunk is_a: UBERON:0014792 ! musculature of pelvic complex intersection_of: UBERON:0001015 ! musculature intersection_of: BFO:0000050 UBERON:0001271 ! part of pelvic girdle region relationship: BFO:0000050 UBERON:0001271 ! part of pelvic girdle region [Term] id: UBERON:0004471 name: musculature of pectoral girdle def: "A subdivision of the musculature of the body in the pectoral girdle region. Includes pectoral and shoulder muscles." [https://orcid.org/0000-0002-6601-2165] subset: pheno_slim synonym: "muscle group of pectoral girdle" EXACT [FMA:33519] synonym: "pectoral girdle muscles" EXACT [AAO:0000423] synonym: "pectoral girdle musculature" EXACT [FMA:33519] synonym: "set of muscles of pectoral girdle" EXACT [FMA:33519] xref: AAO:0000423 xref: EMAPA:37857 {source="MA:th"} xref: FMA:33519 is_a: UBERON:0014793 ! musculature of pectoral complex intersection_of: UBERON:0001015 ! musculature intersection_of: BFO:0000050 UBERON:0001421 ! part of pectoral girdle region relationship: BFO:0000050 UBERON:0001421 ! part of pectoral girdle region property_value: skos:prefLabel "musculature of pectoral girdle" xsd:string [Term] id: UBERON:0004473 name: musculature of face def: "Any collection of muscles that is part of a face." [OBOL:automatic] subset: pheno_slim synonym: "entire facial musculature" EXACT [https://orcid.org/0000-0002-6601-2165] synonym: "facial muscles" EXACT [FMA:71288] synonym: "muscle group of face" EXACT [FMA:71288] synonym: "musculi faciei" EXACT OMO:0003011 [FMA:71288, FMA:TA] synonym: "set of facial muscles" RELATED [FMA:71288] synonym: "set of muscles of face" RELATED [FMA:71288] xref: FMA:71288 is_a: UBERON:0008229 ! craniocervical region musculature intersection_of: UBERON:0001015 ! musculature intersection_of: BFO:0000050 UBERON:0001456 ! part of face relationship: BFO:0000050 UBERON:0001456 ! part of face property_value: IAO:0000116 "originally created to reflect the distinction drawn in FMA between a facial muscle and the entire musculature of the face. However, naming both does not serve any particular purpose" xsd:string property_value: skos:prefLabel "musculature of face" xsd:string [Term] id: UBERON:0004474 name: musculature of arm def: "Any collection of muscles that is part of an arm [Automatically generated definition]." [OBOL:automatic] subset: pheno_slim synonym: "arm muscle system" EXACT [EHDAA2:0000141] synonym: "arm musculature" EXACT [FMA:50202] synonym: "muscle group of arm" EXACT [FMA:50202] synonym: "set of muscles of arm" EXACT [FMA:50202] xref: EHDAA2:0000141 is_a: UBERON:0004481 ! musculature of upper limb intersection_of: UBERON:0001015 ! musculature intersection_of: BFO:0000050 UBERON:0001460 ! part of arm relationship: BFO:0000050 UBERON:0001460 ! part of arm [Term] id: UBERON:0004475 name: musculature of hip def: "The collection of muscles that form attachments to the hip skeleton." [http://orcid.org/0000-0002-6601-2165] subset: pheno_slim synonym: "hip musculature" EXACT [FMA:50227] synonym: "muscle group of hip" EXACT [FMA:50227] synonym: "set of muscles of hip" EXACT [FMA:50227] xref: FMA:50227 is_a: UBERON:0001015 ! musculature intersection_of: UBERON:0001015 ! musculature intersection_of: RO:0002371 UBERON:0008202 ! attached to bone of hip region relationship: RO:0002131 UBERON:0001464 ! overlaps hip relationship: RO:0002371 UBERON:0008202 ! attached to bone of hip region [Term] id: UBERON:0004476 name: musculature of shoulder def: "The collection of muscles that form attachments to the shoulder skeleton." [http://orcid.org/0000-0002-6601-2165] subset: pheno_slim synonym: "muscle group of shoulder" EXACT [FMA:50220] synonym: "set of muscles of shoulder" EXACT [FMA:50220] xref: FMA:50220 is_a: UBERON:0001015 ! musculature intersection_of: UBERON:0001015 ! musculature intersection_of: RO:0002371 UBERON:0003461 ! attached to shoulder bone relationship: RO:0002131 UBERON:0001467 ! overlaps shoulder relationship: RO:0002371 UBERON:0003461 ! attached to shoulder bone [Term] id: UBERON:0004478 name: musculature of larynx def: "The collection of muscles that are part of the larynx." [http://orcid.org/0000-0002-6601-2165] synonym: "laryngeal muscles" EXACT [FMA:46616] synonym: "laryngeal muscles set" EXACT [FMA:46616] synonym: "muscle group of larynx" EXACT [FMA:46616] synonym: "set of laryngeal muscles" EXACT [FMA:46616] synonym: "set of muscles of larynx" EXACT [FMA:264611] xref: FMA:264611 xref: FMA:46616 xref: MESH:D007821 xref: Wikipedia:Muscles_of_larynx is_a: UBERON:0001015 ! musculature intersection_of: UBERON:0001015 ! musculature intersection_of: BFO:0000050 UBERON:0001737 ! part of larynx relationship: BFO:0000050 UBERON:0001737 ! part of larynx property_value: IAO:0000116 "currently defined by location rather than attachment" xsd:string property_value: skos:prefLabel "musculature of larynx" xsd:string [Term] id: UBERON:0004479 name: musculature of trunk def: "Any collection of muscles that is part of a trunk [Automatically generated definition]." [OBOL:automatic] subset: efo_slim subset: pheno_slim synonym: "muscle group of trunk" EXACT [FMA:50187] synonym: "muscular system of trunk" RELATED [FMA:50187] synonym: "set of muscles of trunk" EXACT [FMA:50187] xref: AAO:0011572 xref: EFO:0003531 xref: FMA:50187 is_a: UBERON:0001015 ! musculature intersection_of: UBERON:0001015 ! musculature intersection_of: BFO:0000050 UBERON:0002100 ! part of trunk relationship: BFO:0000050 UBERON:0002100 ! part of trunk property_value: IAO:0000116 "currently defined by location rather than attachment" xsd:string property_value: skos:prefLabel "musculature of trunk" xsd:string [Term] id: UBERON:0004480 name: musculature of limb def: "Any collection of muscles that is part of a limb [Automatically generated definition]." [OBOL:automatic] subset: pheno_slim synonym: "limb muscle system" EXACT [EHDAA2:0000995] synonym: "limb musculature" EXACT [FMA:50188] synonym: "muscle group of limb" EXACT [FMA:50188] synonym: "set of muscles of limb" EXACT [FMA:50188] xref: EHDAA2:0000995 xref: EMAPA:32700 xref: FMA:50188 is_a: UBERON:0007271 ! appendage musculature intersection_of: UBERON:0001015 ! musculature intersection_of: BFO:0000050 UBERON:0002101 ! part of limb relationship: BFO:0000050 UBERON:0002101 ! part of limb property_value: IAO:0000116 "currently defined by location rather than attachment" xsd:string [Term] id: UBERON:0004481 name: musculature of upper limb def: "Any collection of muscles that is part of a forelimb [Automatically generated definition]." [OBOL:automatic] subset: pheno_slim synonym: "free upper limb musculature" EXACT [FMA:50396] synonym: "muscle group of free upper limb" EXACT [FMA:50396] synonym: "musculature of free upper limb" EXACT [FMA:50396] synonym: "set of muscles of free upper limb" EXACT [FMA:50396] xref: FMA:50396 is_a: UBERON:0004480 ! musculature of limb is_a: UBERON:0007269 ! pectoral appendage musculature intersection_of: UBERON:0001015 ! musculature intersection_of: BFO:0000050 UBERON:0002102 ! part of forelimb relationship: BFO:0000050 UBERON:0002102 ! part of forelimb property_value: IAO:0000116 "currently defined by location rather than attachment" xsd:string [Term] id: UBERON:0004482 name: musculature of lower limb def: "Any collection of muscles that is part of a hindlimb [Automatically generated definition]." [OBOL:automatic] subset: pheno_slim synonym: "free lower limb musculature" EXACT [FMA:50399] synonym: "muscle group of free lower limb" EXACT [FMA:50399] synonym: "musculature of free lower limb" EXACT [FMA:50399] synonym: "set of muscles of free lower limb" EXACT [FMA:50399] xref: FMA:50399 is_a: UBERON:0004480 ! musculature of limb is_a: UBERON:0007270 ! pelvic appendage musculature intersection_of: UBERON:0001015 ! musculature intersection_of: BFO:0000050 UBERON:0002103 ! part of hindlimb relationship: BFO:0000050 UBERON:0002103 ! part of hindlimb property_value: IAO:0000116 "currently defined by location rather than attachment" xsd:string [Term] id: UBERON:0004487 name: musculature of forelimb zeugopod def: "Any collection of muscles that is part of a lower arm [Automatically generated definition]." [OBOL:automatic] synonym: "muscle group of forearm" EXACT [FMA:39089] synonym: "musculature of forearm" EXACT [FMA:39089] synonym: "set of muscles of forearm" EXACT [FMA:39089] xref: FMA:39089 is_a: UBERON:0004474 ! musculature of arm intersection_of: UBERON:0001015 ! musculature intersection_of: BFO:0000050 UBERON:0002386 ! part of forelimb zeugopod relationship: BFO:0000050 UBERON:0002386 ! part of forelimb zeugopod [Term] id: UBERON:0004488 name: musculature of pes def: "Any collection of muscles that is part of a foot [Automatically generated definition]." [OBOL:automatic] subset: pheno_slim synonym: "foot musculature" EXACT [FMA:50214] synonym: "muscle group of foot" EXACT [FMA:50214] synonym: "musculature of foot" EXACT [FMA:50214] synonym: "set of muscles of foot" EXACT [FMA:50214] xref: FMA:50214 is_a: UBERON:0004482 ! musculature of lower limb intersection_of: UBERON:0001015 ! musculature intersection_of: BFO:0000050 UBERON:0002387 ! part of pes relationship: BFO:0000050 UBERON:0002387 ! part of pes property_value: IAO:0000116 "currently defined by location rather than attachment" xsd:string [Term] id: UBERON:0004489 name: musculature of manus def: "Any collection of muscles that is part of a manus [Automatically generated definition]." [OBOL:automatic] subset: pheno_slim synonym: "hand musculature" EXACT [FMA:42368] synonym: "muscle group of hand" EXACT [FMA:42368] synonym: "musculature of hand" EXACT [FMA:42368] synonym: "set of muscles of hand" EXACT [FMA:42368] xref: FMA:42368 is_a: UBERON:0004481 ! musculature of upper limb intersection_of: UBERON:0001015 ! musculature intersection_of: BFO:0000050 UBERON:0002398 ! part of manus relationship: BFO:0000050 UBERON:0002398 ! part of manus property_value: IAO:0000116 "currently defined by location rather than attachment" xsd:string [Term] id: UBERON:0004490 name: cardiac muscle tissue of atrium def: "A portion of cardiac muscle tissue that is part of an atrium [Automatically generated definition]." [OBOL:automatic] synonym: "atrial cardiac muscle tissue" EXACT [GO:0055009] synonym: "atrial heart muscle" EXACT [GO:0055009] synonym: "atrial myocardium" RELATED [GO:0055009, GOC:mtg_heart] synonym: "cardiac atrium muscle" EXACT [GO:0055009] xref: FMA:7283 is_a: UBERON:0004493 ! cardiac muscle tissue of myocardium intersection_of: UBERON:0001133 ! cardiac muscle tissue intersection_of: BFO:0000050 UBERON:0002081 ! part of cardiac atrium relationship: BFO:0000050 UBERON:0002302 ! part of myocardium of atrium property_value: skos:prefLabel "cardiac muscle tissue of atrium" xsd:string [Term] id: UBERON:0004491 name: cardiac muscle tissue of interatrial septum def: "A portion of cardiac muscle tissue that is part of a interatrial septum [Automatically generated definition]." [OBOL:automatic] subset: human_reference_atlas synonym: "interatrial septum cardiac muscle tissue" EXACT [http://orcid.org/0000-0002-6601-2165] synonym: "interatrial septum heart muscle" EXACT [http://orcid.org/0000-0002-6601-2165] synonym: "interatrial septum muscle" EXACT [http://orcid.org/0000-0002-6601-2165] synonym: "interatrial septum myocardium" EXACT [http://orcid.org/0000-0002-6601-2165] xref: FMA:84083 is_a: UBERON:0004492 ! cardiac muscle tissue of cardiac septum intersection_of: UBERON:0001133 ! cardiac muscle tissue intersection_of: BFO:0000050 UBERON:0002085 ! part of interatrial septum relationship: BFO:0000050 UBERON:0002085 ! part of interatrial septum property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "cardiac muscle tissue of interatrial septum" xsd:string [Term] id: UBERON:0004492 name: cardiac muscle tissue of cardiac septum def: "A portion of cardiac muscle tissue that is part of a cardiac septum [Automatically generated definition]." [OBOL:automatic] synonym: "cardiac septum cardiac muscle tissue" EXACT [http://orcid.org/0000-0002-6601-2165] synonym: "cardiac septum heart muscle" EXACT [http://orcid.org/0000-0002-6601-2165] synonym: "cardiac septum muscle" EXACT [http://orcid.org/0000-0002-6601-2165] synonym: "cardiac septum myocardium" EXACT [http://orcid.org/0000-0002-6601-2165] xref: FMA:226279 is_a: UBERON:0001133 ! cardiac muscle tissue intersection_of: UBERON:0001133 ! cardiac muscle tissue intersection_of: BFO:0000050 UBERON:0002099 ! part of cardiac septum relationship: BFO:0000050 UBERON:0002099 ! part of cardiac septum property_value: skos:prefLabel "cardiac muscle tissue of cardiac septum" xsd:string [Term] id: UBERON:0004493 name: cardiac muscle tissue of myocardium def: "A portion of cardiac muscle tissue that is part of a myocardium [Automatically generated definition]." [OBOL:automatic] subset: pheno_slim xref: FMA:261726 xref: MA:0002441 is_a: UBERON:0001133 ! cardiac muscle tissue intersection_of: UBERON:0001133 ! cardiac muscle tissue intersection_of: BFO:0000050 UBERON:0002349 ! part of myocardium relationship: BFO:0000050 UBERON:0002349 {source="MA"} ! part of myocardium property_value: IAO:0000116 "Note placement of MA class based on parthood relationship" xsd:string property_value: skos:prefLabel "cardiac muscle tissue of myocardium" xsd:string [Term] id: UBERON:0004495 name: skeletal muscle tissue of diaphragm def: "A portion of skeletal muscle tissue that is part of a diaphragm [Automatically generated definition]." [OBOL:automatic] xref: FMA:261898 is_a: UBERON:0003898 ! skeletal muscle tissue of trunk is_a: UBERON:0004830 ! respiratory system skeletal muscle intersection_of: UBERON:0001134 ! skeletal muscle tissue intersection_of: BFO:0000050 UBERON:0001103 ! part of diaphragm relationship: BFO:0000050 UBERON:0001103 ! part of diaphragm property_value: skos:prefLabel "skeletal muscle tissue of diaphragm" xsd:string [Term] id: UBERON:0004500 name: skeletal muscle tissue of deltoid def: "A portion of skeletal muscle tissue that is part of a deltoid [Automatically generated definition]." [OBOL:automatic] synonym: "skeletal muscle tissue of deltoid muscle" RELATED [FMA:261732] xref: FMA:261732 is_a: UBERON:0001134 ! skeletal muscle tissue intersection_of: UBERON:0001134 ! skeletal muscle tissue intersection_of: BFO:0000050 UBERON:0001476 ! part of deltoid relationship: BFO:0000050 UBERON:0001476 ! part of deltoid [Term] id: UBERON:0004509 name: skeletal muscle tissue of trapezius def: "A portion of skeletal muscle tissue that is part of a trapezius [Automatically generated definition]." [OBOL:automatic] synonym: "skeletal muscle tissue of trapezius muscle" RELATED [FMA:261938] xref: FMA:261938 is_a: UBERON:0001134 ! skeletal muscle tissue intersection_of: UBERON:0001134 ! skeletal muscle tissue intersection_of: BFO:0000050 UBERON:0002380 ! part of trapezius muscle relationship: BFO:0000050 UBERON:0002380 ! part of trapezius muscle [Term] id: UBERON:0004510 name: skeletal muscle tissue of pectoralis major def: "A portion of skeletal muscle tissue that is part of a pectoralis major [Automatically generated definition]." [OBOL:automatic] synonym: "skeletal muscle tissue of pectoralis major muscle" RELATED [FMA:261968] xref: FMA:261968 is_a: UBERON:0003898 ! skeletal muscle tissue of trunk intersection_of: UBERON:0001134 ! skeletal muscle tissue intersection_of: BFO:0000050 UBERON:0002381 ! part of pectoralis major relationship: BFO:0000050 UBERON:0002381 ! part of pectoralis major [Term] id: UBERON:0004515 name: smooth muscle tissue of bronchiole def: "A portion of smooth muscle tissue that is part of a bronchiole [Automatically generated definition]." [OBOL:automatic] subset: human_reference_atlas xref: FMA:261045 is_a: UBERON:0004233 ! lower respiratory tract smooth muscle intersection_of: UBERON:0001135 ! smooth muscle tissue intersection_of: BFO:0000050 UBERON:0002186 ! part of bronchiole relationship: BFO:0000050 UBERON:0002186 ! part of bronchiole property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0004516 name: smooth muscle tissue of terminal bronchiole def: "A portion of smooth muscle tissue that is part of a terminal bronchiole [Automatically generated definition]." [OBOL:automatic] subset: human_reference_atlas xref: FMA:261051 is_a: UBERON:0004515 ! smooth muscle tissue of bronchiole intersection_of: UBERON:0001135 ! smooth muscle tissue intersection_of: BFO:0000050 UBERON:0002187 ! part of terminal bronchiole relationship: BFO:0000050 UBERON:0002187 ! part of terminal bronchiole relationship: BFO:0000051 CL:4033017 ! has part bronchiolar smooth muscle cell property_value: RO:0002175 NCBITaxon:9606 property_value: terms:contributor https://orcid.org/0000-0001-6677-8489 [Term] id: UBERON:0004517 name: smooth muscle tissue of respiratory bronchiole def: "A portion of smooth muscle tissue that is part of a respiratory bronchiole [Automatically generated definition]." [OBOL:automatic] subset: human_reference_atlas xref: FMA:261055 is_a: UBERON:0004515 ! smooth muscle tissue of bronchiole intersection_of: UBERON:0001135 ! smooth muscle tissue intersection_of: BFO:0000050 UBERON:0002188 ! part of respiratory bronchiole relationship: BFO:0000050 UBERON:0002188 ! part of respiratory bronchiole relationship: BFO:0000051 CL:4033017 ! has part bronchiolar smooth muscle cell property_value: RO:0002175 NCBITaxon:9606 property_value: terms:contributor https://orcid.org/0000-0001-6677-8489 [Term] id: UBERON:0004518 name: muscle of vertebral column def: "A muscle that is attached to a vertebra of the vertebral column." [https://orcid.org/0000-0002-6601-2165] synonym: "vertebral column muscle" EXACT [FMA:22594] xref: FMA:22594 is_a: UBERON:0014892 ! skeletal muscle organ, vertebrate intersection_of: UBERON:0014892 ! skeletal muscle organ, vertebrate intersection_of: RO:0002371 UBERON:0002412 ! attached to vertebra relationship: RO:0002371 UBERON:0002412 ! attached to vertebra property_value: skos:prefLabel "muscle of vertebral column" xsd:string [Term] id: UBERON:0004520 name: striated muscle tissue of prostate def: "A portion of striated muscle tissue that is part of a prostate gland [Automatically generated definition]." [OBOL:automatic] xref: FMA:45716 is_a: UBERON:0001134 ! skeletal muscle tissue is_a: UBERON:0008715 ! muscle tissue of prostate intersection_of: UBERON:0002036 ! striated muscle tissue intersection_of: BFO:0000050 UBERON:0002367 ! part of prostate gland [Term] id: UBERON:0004521 name: vasculature of muscle organ def: "A vasculature that is part of a muscle organ [Automatically generated definition]." [OBOL:automatic] synonym: "muscular organ vasculature" EXACT [FMA:87123] xref: FMA:87123 is_a: UBERON:0006876 ! vasculature of organ intersection_of: UBERON:0002049 ! vasculature intersection_of: BFO:0000050 UBERON:0001630 ! part of muscle organ relationship: BFO:0000050 UBERON:0001630 ! part of muscle organ property_value: skos:prefLabel "vasculature of muscle organ" xsd:string [Term] id: UBERON:0004522 name: vasculature of musculoskeletal system def: "A vasculature that is part of a musculoskeletal system [Automatically generated definition]." [OBOL:automatic] xref: FMA:239607 is_a: UBERON:0002049 ! vasculature intersection_of: UBERON:0002049 ! vasculature intersection_of: BFO:0000050 UBERON:0002204 ! part of musculoskeletal system relationship: BFO:0000050 UBERON:0002204 ! part of musculoskeletal system property_value: skos:prefLabel "vasculature of musculoskeletal system" xsd:string [Term] id: UBERON:0004525 name: cardiac muscle tissue of trabecula carnea of right ventricle def: "A portion of trabecula carnea cardiac muscle tissue that is part of a right ventricle [Automatically generated definition]." [OBOL:automatic] xref: FMA:84429 is_a: UBERON:0003381 ! cardiac muscle of right ventricle is_a: UBERON:0003452 ! trabecula carnea cardiac muscle tissue intersection_of: UBERON:0003452 ! trabecula carnea cardiac muscle tissue intersection_of: BFO:0000050 UBERON:0002080 ! part of heart right ventricle relationship: BFO:0000050 UBERON:0006570 {is_inferred="true", source="https://github.com/obophenotype/uberon/wiki/Inferring-part-of-relationships"} ! part of trabecula carnea of right ventricle [Term] id: UBERON:0004526 name: cardiac muscle tissue of trabecula carnea of left ventricle def: "A portion of trabecula carnea cardiac muscle tissue that is part of a left ventricle [Automatically generated definition]." [OBOL:automatic] xref: FMA:84430 is_a: UBERON:0003382 ! cardiac muscle of left ventricle is_a: UBERON:0003452 ! trabecula carnea cardiac muscle tissue intersection_of: UBERON:0003452 ! trabecula carnea cardiac muscle tissue intersection_of: BFO:0000050 UBERON:0002084 ! part of heart left ventricle relationship: BFO:0000050 UBERON:0006571 {is_inferred="true", source="https://github.com/obophenotype/uberon/wiki/Inferring-part-of-relationships"} ! part of trabecula carnea of left ventricle [Term] id: UBERON:0004529 name: anatomical projection def: "A projection or outgrowth of tissue from a larger body or organ." [https://github.com/obophenotype/uberon/issues/39, Wikipedia:Process_(anatomy)] subset: common_anatomy subset: upper_level synonym: "anatomical process" BROAD [] synonym: "anatomical protrusion" RELATED [] synonym: "flange" NARROW [VSAO:0000180] synonym: "flanges" NARROW OMO:0003004 [VSAO:0000180] synonym: "lamella" NARROW [VSAO:0000180] synonym: "lamellae" NARROW OMO:0003004 [VSAO:0000180] synonym: "lamina" NARROW [VSAO:0000180] synonym: "laminae" NARROW [VSAO:0000180] synonym: "organ process" NARROW [] synonym: "papilla" NARROW [] synonym: "process" BROAD [VSAO:0000180] synonym: "process of organ" NARROW [] synonym: "processes" NARROW OMO:0003004 [VSAO:0000180] synonym: "processus" EXACT OMO:0003011 [FMA:67601, FMA:TA] synonym: "projection" EXACT [] synonym: "projection" NARROW [VSAO:0000180] synonym: "projections" NARROW OMO:0003004 [VSAO:0000180] synonym: "protrusion" RELATED [] synonym: "ridge" NARROW [VSAO:0000180] synonym: "ridges" NARROW OMO:0003004 [VSAO:0000180] synonym: "shelf" NARROW [VSAO:0000180] synonym: "shelves" NARROW OMO:0003004 [VSAO:0000180] synonym: "spine" RELATED [] xref: AAO:0010278 xref: FMA:67601 xref: galen:Ridge xref: HAO:0000822 xref: NCIT:C61549 xref: TAO:0001834 xref: VSAO:0000180 xref: Wikipedia:Process_(anatomy) xref: XAO:0004020 is_a: UBERON:0034768 ! morphological feature relationship: BFO:0000050 UBERON:0000062 ! part of organ property_value: IAO:0000116 "should be declared disjoint from organ, but in some ontologies (e.g. ZFA), structures such as neural spines are classified as bones (and hence organs)" xsd:string property_value: RO:0002175 NCBITaxon:33090 property_value: RO:0002175 NCBITaxon:33208 property_value: RO:0002175 NCBITaxon:4751 property_value: terms:contributor https://orcid.org/0000-0002-6601-2165 property_value: terms:contributor https://orcid.org/0000-0003-3162-7490 [Term] id: UBERON:0004530 name: bony projection def: "Anatomical projection that is composed of bone tissue." [VSAO:wd] subset: vertebrate_core synonym: "bone process" EXACT [FMA:75433] synonym: "bony projections" RELATED OMO:0003004 [ZFA:0001637] synonym: "projection of bone" EXACT [] xref: FMA:75433 xref: ZFA:0001637 is_a: BFO:0000002 is_a: UBERON:4100000 ! skeletal element projection intersection_of: UBERON:4100000 ! skeletal element projection intersection_of: RO:0002473 UBERON:0002481 ! composed primarily of bone tissue relationship: RO:0002150 UBERON:0004765 ! continuous with skeletal element relationship: RO:0002473 UBERON:0002481 ! composed primarily of bone tissue [Term] id: UBERON:0004533 name: left testis def: "A testis that is in the left side of the genitalia [Automatically generated definition]." [OBOL:automatic] synonym: "left testicle" EXACT [MA:0001746] xref: EMAPA:37370 {source="MA:th"} xref: FMA:7212 xref: MA:0001746 xref: NCIT:C49323 xref: SCTID:367720001 xref: UMLS:C0227998 {source="ncithesaurus:Left_Testis"} is_a: UBERON:0000473 ! testis is_a: UBERON:0015212 ! lateral structure intersection_of: UBERON:0000473 ! testis intersection_of: BSPO:0000120 UBERON:0000990 ! reproductive system relationship: BSPO:0000120 UBERON:0000990 ! reproductive system [Term] id: UBERON:0004534 name: right testis def: "A testis that is in the right side of the genitalia [Automatically generated definition]." [OBOL:automatic] synonym: "right testicle" EXACT [MA:0001747] xref: EMAPA:37371 {source="MA:th"} xref: FMA:7211 xref: MA:0001747 xref: NCIT:C49326 xref: SCTID:367719007 xref: UMLS:C0227997 {source="ncithesaurus:Right_Testis"} is_a: UBERON:0000473 ! testis is_a: UBERON:0015212 ! lateral structure intersection_of: UBERON:0000473 ! testis intersection_of: BSPO:0000121 UBERON:0000990 ! reproductive system relationship: BSPO:0000121 UBERON:0000990 ! reproductive system [Term] id: UBERON:0004535 name: cardiovascular system def: "Anatomical system that has as its parts the heart and blood vessels." [BTO:0000088] subset: efo_slim subset: human_reference_atlas subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "CV system" RELATED [BTO:0000088] synonym: "Herz und Gefaesssystem" RELATED [BTO:0000088] xref: AAO:0011001 xref: BILA:0000016 xref: BTO:0000088 xref: CALOHA:TS-1297 xref: EFO:0000791 xref: EHDAA:394 xref: EMAPA:16104 xref: EV:0100017 xref: FMA:7161 xref: GAID:467 xref: MA:0000010 xref: MAT:0000016 xref: MESH:D002319 xref: MIAA:0000016 xref: NCIT:C12686 xref: SCTID:278198007 xref: TAO:0000010 xref: UMLS:C0007226 {source="ncithesaurus:Cardiovascular_System"} xref: VHOG:0000302 xref: WikipediaCategory:Cardiovascular_system xref: XAO:0000100 xref: XAO:0001010 xref: ZFA:0000010 is_a: UBERON:0000467 ! anatomical system is_a: UBERON:0010314 ! structure with developmental contribution from neural crest intersection_of: UBERON:0000467 ! anatomical system intersection_of: BFO:0000050 UBERON:0001009 ! part of circulatory system intersection_of: BFO:0000051 UBERON:0000948 ! has part heart intersection_of: BFO:0000051 UBERON:0001981 ! has part blood vessel relationship: BFO:0000050 UBERON:0001009 ! part of circulatory system relationship: BFO:0000051 UBERON:0000948 ! has part heart relationship: BFO:0000051 UBERON:0001981 ! has part blood vessel property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "cardiovascular system" xsd:string [Term] id: UBERON:0004536 name: lymph vasculature def: "A network of blunt ended vessels lacking direct connection to the blood vascular system. These vessels collect and drain fluids and macromolecules from interstitial spaces throughout the animal. They derive from a subpopulation of endothelial cells and have walls that are much thinner than the blood carrying vessels. Lymphatic vessels are usually classified as either superficial or deep." [ZFA:0005105] subset: human_reference_atlas subset: vertebrate_core synonym: "lymph vessels" RELATED OMO:0003004 [ZFA:0005105] synonym: "lymphatic trunks and ducts" EXACT [FMA:63815] synonym: "lymphatic vasculature" EXACT [] synonym: "lymphatic vessel network" EXACT [] synonym: "lymphatic vessels set" EXACT [FMA:63815] synonym: "set of lymphatic vessels" EXACT [] synonym: "trunci et ductus lymphatici" EXACT OMO:0003011 [FMA:63815, FMA:TA] xref: FMA:63815 xref: ZFA:0005105 is_a: BFO:0000002 is_a: UBERON:0002049 ! vasculature intersection_of: UBERON:0002049 ! vasculature intersection_of: BFO:0000051 UBERON:0002391 ! has part lymph relationship: BFO:0000050 UBERON:0006558 ! part of lymphatic part of lymphoid system relationship: BFO:0000051 UBERON:0002391 ! has part lymph property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/lymph-node-female/v1.4/assets/3d-nih-f-lymph-node.glb" xsd:anyURI property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/lymph-node-male/v1.4/assets/3d-nih-m-lymph-node.glb" xsd:anyURI property_value: IAO:0000116 "consider merging with parent" xsd:string property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0004537 name: blood vasculature def: "A vascular network consisting of blood vessels." [https://orcid.org/0000-0002-6601-2165] subset: human_reference_atlas synonym: "blood system" RELATED [] synonym: "blood vascular network" EXACT [] synonym: "blood vessel system" RELATED [] synonym: "blood vessels" RELATED [TAO:0001079] synonym: "set of blood vessels" EXACT [] xref: TAO:0001079 xref: ZFA:0001079 is_a: BFO:0000002 is_a: UBERON:0002049 ! vasculature intersection_of: UBERON:0002049 ! vasculature intersection_of: RO:0002473 UBERON:0001981 ! composed primarily of blood vessel relationship: RO:0002473 UBERON:0001981 ! composed primarily of blood vessel property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/blood-vasculature-female/v1.3/assets/3d-vh-f-blood-vasculature.glb" xsd:anyURI property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/blood-vasculature-male/v1.3/assets/3d-vh-m-blood-vasculature.glb" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "blood vasculature" xsd:string [Term] id: UBERON:0004538 name: left kidney def: "A kidney that is part of a left side of organism [Automatically generated definition]." [OBOL:automatic] subset: pheno_slim xref: EMAPA:36589 xref: FMA:7205 xref: MA:0001655 xref: NCIT:C34006 xref: SCTID:362209008 xref: UMLS:C0227614 {source="ncithesaurus:Left_Kidney"} is_a: UBERON:0002113 ! kidney intersection_of: UBERON:0002113 ! kidney intersection_of: BSPO:0000120 UBERON:0000468 ! multicellular organism relationship: BSPO:0000120 UBERON:0000468 ! multicellular organism property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/kidney-female-left/v1.3/assets/3d-vh-f-kidney-l.glb" xsd:anyURI property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/kidney-male-left/v1.3/assets/3d-vh-m-kidney-l.glb" xsd:anyURI [Term] id: UBERON:0004539 name: right kidney def: "A kidney that is part of a right side of organism [Automatically generated definition]." [OBOL:automatic] subset: pheno_slim xref: EMAPA:36590 xref: FMA:7204 xref: MA:0001683 xref: NCIT:C34005 xref: SCTID:362208000 xref: UMLS:C0227613 {source="ncithesaurus:Right_Kidney"} is_a: UBERON:0002113 ! kidney intersection_of: UBERON:0002113 ! kidney intersection_of: BSPO:0000121 UBERON:0000468 ! multicellular organism relationship: BSPO:0000121 UBERON:0000468 ! multicellular organism property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/kidney-female-right/v1.3/assets/3d-vh-f-kidney-r.glb" xsd:anyURI property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/kidney-male-right/v1.3/assets/3d-vh-m-kidney-r.glb" xsd:anyURI [Term] id: UBERON:0004544 name: epididymis epithelium def: "The layer of secretory cells which lines the epididymis." [MGI:csmith, MP:0004933] subset: pheno_slim synonym: "epididymis epithelium" EXACT [FMA:19153] synonym: "epithelium of epididymis" EXACT [FMA:19153] xref: BTO:0005768 xref: CALOHA:TS-2063 xref: EMAPA:30445 xref: FMA:19153 xref: MA:0002825 is_a: UBERON:0000485 ! simple columnar epithelium is_a: UBERON:0005156 ! reproductive structure is_a: UBERON:0034969 ! epithelial layer of duct intersection_of: UBERON:0000485 ! simple columnar epithelium intersection_of: BFO:0000050 UBERON:0001301 ! part of epididymis relationship: BFO:0000050 UBERON:0001301 ! part of epididymis relationship: RO:0002433 UBERON:0001301 ! contributes to morphology of epididymis [Term] id: UBERON:0004545 name: external capsule of telencephalon def: "Any of the series of white matter fiber tracts in the brain that run between the most lateral segment of the lentiform nucleus and the claustrum; the white matter of the external capsule contains fibers known as corticocortical association fibers which are responsible for connecting the cerebral cortex to another cortical area; the capsule appears as a thin white sheet of white matter and provides a route for cholinergic fibers from the basal forebrain to the cerebral cortex; it eventually joins the internal capsule around the lentiform nucleus." [MP:0020139] synonym: "brain external capsule" BROAD [MP:0020139] synonym: "capsula externa" RELATED OMO:0003011 [Wikipedia:External_capsule] synonym: "corpus callosum external capsule" RELATED [BAMS:ec] synonym: "external capsule" BROAD [MA:0002896] xref: BAMS:EC xref: BAMS:ec xref: DHBA:10573 xref: DMBA:17765 xref: EMAPA:35331 xref: FMA:61959 xref: HBA:9243 xref: MA:0002896 xref: MBA:579 xref: NCIT:C32550 xref: neuronames:253 xref: NLXANAT:1010013 xref: SCTID:279300007 xref: UMLS:C0152345 {source="ncithesaurus:External_Capsule"} xref: Wikipedia:External_capsule is_a: UBERON:0002437 ! cerebral hemisphere white matter relationship: BFO:0000050 UBERON:0002437 {source="FMA"} ! part of cerebral hemisphere white matter property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/9/91/Telencephalon-Horiconatal.jpg" xsd:anyURI property_value: skos:prefLabel "external capsule of telencephalon" xsd:string [Term] id: UBERON:0004548 name: left eye def: "An eye that is part of a left side of organism [Automatically generated definition]." [OBOL:automatic] subset: pheno_slim synonym: "left eyeball" EXACT [FMA:12515] synonym: "left orbital part of face" NARROW [FMA:54450] synonym: "left orbital region" NARROW [FMA:54450] xref: EMAPA:37362 {source="MA:th"} xref: FMA:12515 xref: MA:0002949 xref: NCIT:C119334 xref: SCTID:362503005 is_a: UBERON:0000970 ! eye is_a: UBERON:0015212 ! lateral structure intersection_of: UBERON:0000970 ! eye intersection_of: BSPO:0000120 UBERON:0000468 ! multicellular organism relationship: BSPO:0000120 UBERON:0000468 ! multicellular organism property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/eye-female-left/v1.3/assets/3d-vh-f-eye-l.glb" xsd:anyURI property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/eye-male-left/v1.3/assets/3d-vh-m-eye-l.glb" xsd:anyURI property_value: skos:prefLabel "left eye" xsd:string [Term] id: UBERON:0004549 name: right eye def: "An eye that is part of a right side of organism [Automatically generated definition]." [OBOL:automatic] subset: pheno_slim synonym: "right eyeball" EXACT [FMA:12514] synonym: "right orbital part of face" NARROW [FMA:54449] synonym: "right orbital region" NARROW [FMA:54449] xref: EMAPA:37363 {source="MA:th"} xref: FMA:12514 xref: MA:0002950 xref: NCIT:C119333 xref: SCTID:362502000 is_a: UBERON:0000970 ! eye is_a: UBERON:0015212 ! lateral structure intersection_of: UBERON:0000970 ! eye intersection_of: BSPO:0000121 UBERON:0000468 ! multicellular organism relationship: BSPO:0000121 UBERON:0000468 ! multicellular organism property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/eye-female-right/v1.3/assets/3d-vh-f-eye-r.glb" xsd:anyURI property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/eye-male-right/v1.3/assets/3d-vh-m-eye-r.glb" xsd:anyURI property_value: skos:prefLabel "right eye" xsd:string [Term] id: UBERON:0004550 name: gastroesophageal sphincter def: "The thick circular layer of smooth gastric musculature encircling the gastroesophageal junction that functions to reduce backflow into the esophagus from the stomach." [ISBN:0-683-40008-8, MP:0010153] subset: pheno_slim synonym: "cardiac sphincter" EXACT [MA:0002951, MP:0010153] synonym: "cardiac sphincter" RELATED [Wikipedia:Cardia] synonym: "constrictor cardiae" RELATED OMO:0003011 [MP:0010153] synonym: "esophageal sphincter" RELATED [Wikipedia:Cardia] synonym: "esophageal sphincter%2c lower" RELATED [Wikipedia:Cardia] synonym: "esophageal-cardiac junction" RELATED [Wikipedia:Cardia] synonym: "esophagogastric junction" RELATED [Wikipedia:Cardia] synonym: "gastro-esophageal junction" RELATED [Wikipedia:Cardia] synonym: "gastro-esophageal sphincter" RELATED [Wikipedia:Cardia] synonym: "gastro-oesophageal junction" RELATED [Wikipedia:Cardia] synonym: "gastroesophageal junction" RELATED [Wikipedia:Cardia] synonym: "gastroesophageal sphincter" EXACT [FMA:14915] synonym: "gastroesophageal sphincter" RELATED [Wikipedia:Cardia] synonym: "gastroesophageal sphincter muscle" EXACT [] synonym: "inferior esophageal sphincter" EXACT [FMA:14915] synonym: "LES" RELATED OMO:0003000 [Wikipedia:Cardia] synonym: "lower esophageal sphincter" RELATED [MA:0002951, Wikipedia:Cardia] xref: EMAPA:18267 xref: FMA:14915 xref: galen:LowerEsophagealSphincter xref: MA:0002951 xref: MESH:D049630 {sssom:mapping_justification="https://w3id.org/semapv/vocab/LexicalMatching"} xref: NCIT:C33009 xref: SCTID:267809009 xref: UMLS:C0227192 {source="ncithesaurus:Lower_Esophageal_Sphincter"} is_a: UBERON:0011185 ! gastrointestinal sphincter intersection_of: UBERON:0004590 {source="MA"} ! sphincter muscle intersection_of: BFO:0000050 UBERON:0001162 {source="MA"} ! part of cardia of stomach relationship: BFO:0000050 UBERON:0001162 ! part of cardia of stomach relationship: RO:0002433 UBERON:0001162 ! contributes to morphology of cardia of stomach property_value: IAO:0000116 "TODO - split? check FMA:63048 ! circular muscle layer of abdominal part of esophagus" xsd:string [Term] id: UBERON:0004552 name: digital artery def: "An artery that is part of a digit [Automatically generated definition]." [OBOL:automatic] xref: EMAPA:37076 {source="MA:th"} xref: MA:0001941 xref: SCTID:181335004 is_a: UBERON:0001637 ! artery is_a: UBERON:0003514 ! limb blood vessel intersection_of: UBERON:0001637 ! artery intersection_of: BFO:0000050 UBERON:0002544 ! part of digit relationship: BFO:0000050 UBERON:0002544 ! part of digit property_value: IAO:0000116 "check part_of - do we need term for digit + metacarpal/tarsal bones?" xsd:string [Term] id: UBERON:0004553 name: forelimb digital artery def: "A digital artery that is part of a forelimb [Automatically generated definition]." [OBOL:automatic] synonym: "digital artery of manus" EXACT [] synonym: "forelimb digital arteries" EXACT [MA:0001953] synonym: "wing digital artery" NARROW SENSU [NCBITaxon:8782, OBOL:automatic] xref: EMAPA:37210 {source="MA:th"} xref: MA:0001953 xref: SCTID:265791006 is_a: UBERON:0003522 ! manual digit blood vessel is_a: UBERON:0004552 ! digital artery intersection_of: UBERON:0004552 ! digital artery intersection_of: BFO:0000050 UBERON:0002102 ! part of forelimb [Term] id: UBERON:0004554 name: hindlimb digital artery def: "A digital artery that is part of a hindlimb [Automatically generated definition]." [OBOL:automatic] synonym: "digital artery of foot" EXACT [FMA:69713] synonym: "hindlimb digital arteries" EXACT [MA:0001964] xref: EMAPA:37214 {source="MA:th"} xref: FMA:69713 xref: MA:0001964 is_a: UBERON:0003516 ! hindlimb blood vessel is_a: UBERON:0004552 ! digital artery intersection_of: UBERON:0004552 ! digital artery intersection_of: BFO:0000050 UBERON:0002103 ! part of hindlimb [Term] id: UBERON:0004571 name: systemic arterial system def: "The part of the arterial system which carries oxygenated blood away from the heart to the body, and returns deoxygenated blood back to the heart." [http://orcid.org/0000-0002-6601-2165, Wikipedia:Systemic_circulation#Arteries] subset: pheno_slim synonym: "systemic arterial circulatory system" EXACT [FMA:45623] xref: FMA:45623 xref: Wikipedia:Systemic_circulation#Arteries is_a: UBERON:0007798 {source="MA-inferred"} ! vascular system relationship: BFO:0000050 UBERON:0004572 ! part of arterial system property_value: skos:prefLabel "systemic arterial system" xsd:string [Term] id: UBERON:0004572 name: arterial system def: "The part of the cardiovascular system consisting of all arteries." [https://orcid.org/0000-0002-6601-2165] subset: pheno_slim xref: BTO:0004690 xref: EHDAA2:0000143 xref: EHDAA:396 xref: EMAPA:16201 xref: EMAPA:16371 xref: MA:0002719 xref: SCTID:362030008 xref: VHOG:0000273 is_a: BFO:0000002 is_a: UBERON:0007798 {source="MA"} ! vascular system relationship: RO:0002351 UBERON:0001637 ! has member artery property_value: skos:prefLabel "arterial system" xsd:string [Term] id: UBERON:0004573 name: systemic artery def: "An artery of the systemic circulation, which is the part of the cardiovascular system which carries oxygenated blood away from the heart, to the body, and returns deoxygenated blood back to the heart." [http://orcid.org/0000-0002-6601-2165, Wikipedia:Artery#Systemic_arteries] subset: human_reference_atlas subset: pheno_slim synonym: "systemic arterial subtree" EXACT [FMA:66464] xref: EMAPA:37126 {source="MA:th"} xref: FMA:66464 xref: Wikipedia:Artery#Systemic_arteries is_a: UBERON:0001637 ! artery intersection_of: UBERON:0001637 ! artery intersection_of: BFO:0000050 UBERON:0004571 ! part of systemic arterial system relationship: BFO:0000050 UBERON:0004571 ! part of systemic arterial system property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "systemic artery" xsd:string [Term] id: UBERON:0004581 name: systemic venous system def: "The part of the venous system that drains the general body tissues[Kardong]." [ISBN:0073040584, Wikipedia:Systemic_venous_system] synonym: "systemic venous circulatory system" EXACT [FMA:45626] xref: FMA:45626 xref: Wikipedia:Systemic_venous_system is_a: UBERON:0002049 ! vasculature relationship: BFO:0000050 UBERON:0004582 ! part of venous system property_value: skos:prefLabel "systemic venous system" xsd:string [Term] id: UBERON:0004582 name: venous system def: "The part of the cardiovascular system consisting of all venous vessels. In vertebrates with a double circulation, this can be divided into systemic and pulmonary portions." [https://orcid.org/0000-0002-6601-2165] synonym: "vein system" EXACT [] xref: BTO:0004692 xref: EHDAA2:0002171 xref: EHDAA:486 xref: EMAPA:16240 xref: MA:0002720 xref: NCIT:C33858 xref: SCTID:362060003 xref: UMLS:C1267406 {source="ncithesaurus:Venous_System"} xref: VHOG:0000277 is_a: BFO:0000002 is_a: UBERON:0007798 {source="MA"} ! vascular system relationship: RO:0002473 UBERON:0001638 ! composed primarily of vein property_value: skos:prefLabel "venous system" xsd:string [Term] id: UBERON:0004590 name: sphincter muscle def: "A structure, usually a circular muscle, that normally maintains constriction of a natural body passage or orifice and which relaxes as required by normal physiological functioning." [Wikipedia:Sphincter] synonym: "circular muscle" RELATED [] synonym: "sphincter" EXACT [] xref: FMA:75004 xref: NCIT:C28381 xref: UMLS:C1409894 {source="ncithesaurus:Sphincter"} xref: Wikipedia:Sphincter is_a: UBERON:0001630 ! muscle organ property_value: skos:prefLabel "sphincter muscle" xsd:string [Term] id: UBERON:0004637 name: otic capsule def: "The capsule surrounding the inner ear mechanism." [http://www.biology-online.org/dictionary/Otic_capsule] synonym: "auditory capsule" RELATED [VHOG:0000854] synonym: "otic capsule" EXACT [ZFA:0001500] synonym: "otic capsule element" EXACT [https://github.com/obophenotype/uberon/wiki/Modeling-endochondral-elements-Design-Pattern] synonym: "otic capsule endochondral element" EXACT [https://github.com/obophenotype/uberon/wiki/Modeling-endochondral-elements-Design-Pattern] synonym: "otic capsule skeletal element" BROAD [https://github.com/obophenotype/uberon/wiki/Modeling-endochondral-elements-Design-Pattern] synonym: "otic region" RELATED [] synonym: "periotic" RELATED [] synonym: "periotic capsule" RELATED [VHOG:0000854] xref: AAO:0010143 xref: EMAPA:17596 xref: SCTID:361515007 xref: VHOG:0000854 is_a: UBERON:0010363 ! endochondral element relationship: BFO:0000050 UBERON:0001846 ! part of internal ear relationship: BFO:0000050 UBERON:0003110 ! part of otic region property_value: IAO:0000116 "developmental relationships need to be checked" xsd:string property_value: skos:prefLabel "otic capsule" xsd:string [Term] id: UBERON:0004638 name: blood vessel endothelium def: "An endothelium that lines the blood vasculature. Other endothelia may line lymph vessels, the heart." [https://orcid.org/0000-0002-6601-2165] subset: human_reference_atlas subset: pheno_slim subset: vertebrate_core xref: BTO:0000766 xref: CALOHA:TS-2155 xref: EMAPA:35176 xref: MA:0000709 xref: NCIT:C53395 xref: TAO:0005257 xref: UMLS:C1706972 {source="ncithesaurus:Blood_Vessel_Endothelium"} xref: ZFA:0005257 is_a: UBERON:0004852 ! cardiovascular system endothelium intersection_of: UBERON:0001986 ! endothelium intersection_of: BFO:0000050 UBERON:0001981 ! part of blood vessel relationship: BFO:0000050 UBERON:0001981 ! part of blood vessel property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "blood vessel endothelium" xsd:string [Term] id: UBERON:0004639 name: renal afferent arteriole def: "The blood vessels that branch from the kidney interlobular artery, convey blood to the glomerular capillaries, and play an important role in the regulation of blood pressure as a part of the tubuloglomerular feedback mechanism." [ISBN:0-683-40008-8, MGI:csmith, MP:0011312] subset: human_reference_atlas subset: pheno_slim subset: vertebrate_core synonym: "afferent arteriole" EXACT [MA:0002579] synonym: "afferent glomerular arteriole" EXACT [ZFA:0005307] synonym: "afferent glomerular arteriole of kidney" EXACT [FMA:77042] synonym: "arteriola glomerularis afferens" RELATED OMO:0003011 [Wikipedia:Afferent_arterioles] synonym: "arteriola glomerularis afferens renis" EXACT OMO:0003011 [FMA:77042, FMA:TA] synonym: "kidney afferent arteriole" EXACT [MP:0011312] xref: EMAPA:28230 xref: EMAPA:28266 xref: FMA:77042 xref: MA:0002579 xref: SCTID:67498004 xref: TAO:0002139 xref: Wikipedia:Afferent_arterioles xref: ZFA:0005307 is_a: UBERON:0001980 ! arteriole is_a: UBERON:0003644 ! kidney arterial blood vessel relationship: BFO:0000050 UBERON:0001229 ! part of renal corpuscle relationship: RO:0002215 GO:0003093 {source="Wikipedia"} ! capable of regulation of glomerular filtration relationship: RO:0002252 UBERON:0004723 ! connecting branch of interlobular artery relationship: RO:0002433 UBERON:0001229 ! contributes to morphology of renal corpuscle relationship: RO:0020101 UBERON:0001285 ! vessel supplies blood to nephron property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/0/02/Gray1128.png" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0004640 name: renal efferent arteriole def: "The blood vessels that convey blood from the glomerulocapillary network to the capillary bed of the proximal convoluted tubule." [ISBN:0-683-40008-8, MGI:csmith, MP:0011313] subset: human_reference_atlas subset: pheno_slim subset: vertebrate_core synonym: "arteriola glomerularis efferens capsulae renalis" RELATED OMO:0003011 [Wikipedia:Efferent_arteriole] synonym: "arteriola glomerularis efferens renis" EXACT OMO:0003011 [FMA:77043, FMA:TA] synonym: "efferent arteriole" EXACT [MA:0002585] synonym: "efferent glomerular arteriole" EXACT [ZFA:0005308] synonym: "efferent glomerular arteriole of kidney" EXACT [FMA:77043] synonym: "kidney efferent arteriole" EXACT [MP:0011313] xref: EMAPA:28233 xref: EMAPA:28275 xref: FMA:77043 xref: MA:0002585 xref: SCTID:29926005 xref: TAO:0002140 xref: Wikipedia:Efferent_arteriole xref: ZFA:0005308 is_a: UBERON:0001980 ! arteriole is_a: UBERON:0003644 ! kidney arterial blood vessel relationship: BFO:0000050 UBERON:0001229 ! part of renal corpuscle relationship: RO:0002170 UBERON:0004212 ! connected to glomerular capillary relationship: RO:0002215 GO:0003093 {source="Wikipedia"} ! capable of regulation of glomerular filtration relationship: RO:0002433 UBERON:0001229 ! contributes to morphology of renal corpuscle property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/0/02/Gray1128.png" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0004641 name: spleen capsule def: "The connective tissue that surrounds the spleen." [MGI:cwg, MP:0002227] subset: human_reference_atlas subset: pheno_slim synonym: "capsula splenica" EXACT OMO:0003011 [FMA:15849, FMA:TA] synonym: "capsule of spleen" EXACT [FMA:15849] synonym: "fibroelastic coat of spleen" EXACT [FMA:15849] synonym: "fibrous capsule of spleen" EXACT [FMA:15849] synonym: "Malpighian capsule" EXACT [FMA:15849] synonym: "splenic capsule" EXACT [FMA:15849] synonym: "tunica fibrosa (splen)(lien)" EXACT [FMA:15849] synonym: "tunica fibrosa splenica" EXACT OMO:0003011 [FMA:15849, FMA:TA] xref: EMAPA:35802 xref: FMA:15849 xref: MA:0000753 xref: NCIT:C33598 xref: SCTID:329635002 xref: UMLS:C0229681 {source="ncithesaurus:Splenic_Capsule"} is_a: UBERON:0003893 ! capsule intersection_of: UBERON:0003893 ! capsule intersection_of: BFO:0000050 UBERON:0002106 ! part of spleen relationship: BFO:0000050 UBERON:0002106 ! part of spleen relationship: RO:0002433 UBERON:0002106 ! contributes to morphology of spleen property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0004642 name: third ventricle ependyma def: "An ependyma that is part of a third ventricle [Automatically generated definition]." [OBOL:automatic] synonym: "3rd ventricle ependyma" EXACT [MA:0000882] synonym: "ependyma of third ventricle" EXACT [MA:0000882] xref: EMAPA:35100 xref: FMA:242833 xref: MA:0000882 xref: SCTID:362316006 is_a: UBERON:0005357 ! brain ependyma intersection_of: UBERON:0004670 ! ependyma intersection_of: BFO:0000050 UBERON:0002286 ! part of third ventricle relationship: BFO:0000050 UBERON:0002286 ! part of third ventricle property_value: skos:prefLabel "third ventricle ependyma" xsd:string [Term] id: UBERON:0004643 name: lateral ventricle ependyma def: "An ependyma that is part of a lateral ventricle [Automatically generated definition]." [OBOL:automatic] synonym: "ependyma of lateral ventricle" EXACT [FMA:242825] xref: EMAPA:35488 xref: FMA:242825 xref: MA:0000964 xref: NCIT:C49249 xref: SCTID:369275002 xref: UMLS:C0228162 {source="ncithesaurus:Lateral_Ventricle_Ependyma"} is_a: UBERON:0005357 ! brain ependyma intersection_of: UBERON:0004670 ! ependyma intersection_of: BFO:0000050 UBERON:0002285 ! part of telencephalic ventricle relationship: BFO:0000050 UBERON:0002285 ! part of telencephalic ventricle property_value: skos:prefLabel "lateral ventricle ependyma" xsd:string [Term] id: UBERON:0004644 name: fourth ventricle ependyma def: "An ependyma that is part of a fourth ventricle [Automatically generated definition]." [OBOL:automatic] synonym: "4th ventricle ependyma" RELATED [MA:0000986] synonym: "ependyma of fourth ventricle" EXACT [FMA:242835] xref: EMAPA:35355 xref: FMA:242835 xref: MA:0000986 xref: NCIT:C49232 xref: SCTID:369277005 xref: UMLS:C0228171 {source="ncithesaurus:Fourth_Ventricle_Ependyma"} is_a: UBERON:0005357 ! brain ependyma intersection_of: UBERON:0004670 ! ependyma intersection_of: BFO:0000050 UBERON:0002422 ! part of fourth ventricle relationship: BFO:0000050 UBERON:0002422 ! part of fourth ventricle property_value: skos:prefLabel "fourth ventricle ependyma" xsd:string [Term] id: UBERON:0004645 name: urinary bladder urothelium def: "The epithelial lining of the luminal space of the urinary bladder." [MP:0000540] subset: human_reference_atlas subset: pheno_slim synonym: "bladder transitional cell epithelium" EXACT [FMA:15936] synonym: "epithelium of bladder" RELATED [EMAPA:28601] synonym: "transitional epithelium" RELATED [MA:0001693] synonym: "transitional epithelium of urinary bladder" EXACT [FMA:15936] synonym: "urinary bladder transitional epithelium" EXACT [FMA:15936] synonym: "urothelium" BROAD [BTO:0001245] synonym: "urothelium of urinary bladder" EXACT [FMA:15936] xref: BTO:0001694 xref: CALOHA:TS-1088 xref: EMAPA:28601 xref: FMA:15936 xref: MA:0001693 xref: SCTID:25631003 xref: UMLS:C0225339 {source="ncithesaurus:Transitional_Epithelium"} is_a: UBERON:0000365 ! urothelium is_a: UBERON:0003350 ! epithelium of mucosa intersection_of: UBERON:0000365 ! urothelium intersection_of: BFO:0000050 UBERON:0001255 ! part of urinary bladder relationship: BFO:0000050 UBERON:0001259 ! part of mucosa of urinary bladder relationship: RO:0002433 UBERON:0001255 ! contributes to morphology of urinary bladder property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0004647 name: liver lobule def: "The polygonal structure of the liver that consists of hepatocytes radiating outward from a hepatic vein." [ISBN:0-683-40008-8, MP:0008987] subset: human_reference_atlas subset: pheno_slim synonym: "hepatic lobule" EXACT [FMA:14471] synonym: "lobules of liver" RELATED OMO:0003004 [Wikipedia:Lobules_of_liver] synonym: "lobuli hepatici" EXACT OMO:0003004 [] synonym: "lobuli hepatis" RELATED OMO:0003011 [Wikipedia:Lobules_of_liver] synonym: "lobulus hepaticus" EXACT OMO:0003011 [FMA:14471] xref: EMAPA:35499 xref: FMA:14471 xref: MA:0002494 xref: NCIT:C32732 xref: SCTID:362194004 xref: UMLS:C0227518 {source="ncithesaurus:Hepatic_Lobule"} xref: Wikipedia:Lobules_of_liver is_a: BFO:0000002 is_a: UBERON:0000064 {source="FMA"} ! organ part relationship: BFO:0000050 UBERON:0001280 {source="FMA", source="MA"} ! part of liver parenchyma relationship: BFO:0000051 CL:0000182 ! has part hepatocyte relationship: RO:0002433 UBERON:0001280 ! contributes to morphology of liver parenchyma property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "liver lobule" xsd:string [Term] id: UBERON:0004648 name: esophagus muscularis mucosa def: "A muscularis mucosa that is part of a esophagus." [OBOL:automatic] subset: human_reference_atlas synonym: "esophagus muscularis" RELATED [] synonym: "esophagus muscularis mucosae" EXACT [] synonym: "lamina muscularis mucosae (oesphagus)" EXACT OMO:0003011 [FMA:63059, FMA:TA] synonym: "lamina muscularis of esophageal mucous membrane" EXACT [FMA:63059] synonym: "muscularis mucosae of esophagus" EXACT [FMA:63059] xref: EMAPA:26989 xref: FMA:63059 xref: MA:0002681 xref: NCIT:C32540 xref: SCTID:47720007 xref: UMLS:C0227177 {source="ncithesaurus:Esophageal_Muscularis_Mucosa"} is_a: UBERON:0002112 ! smooth muscle of esophagus is_a: UBERON:0006676 ! muscularis mucosa intersection_of: UBERON:0006676 ! muscularis mucosa intersection_of: BFO:0000050 UBERON:0001043 ! part of esophagus relationship: BFO:0000050 UBERON:0002469 ! part of esophagus mucosa property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0004650 name: tongue keratinized epithelium def: "A keratinized stratified squamous epithelium that is part of a tongue." [OBOL:automatic] subset: human_reference_atlas synonym: "keratinized epithelium of tongue" EXACT [FMA:74865] xref: FMA:74865 xref: MA:0002787 is_a: UBERON:0006919 ! tongue squamous epithelium is_a: UBERON:0012329 ! keratinized stratified squamous epithelium intersection_of: UBERON:0012329 ! keratinized stratified squamous epithelium intersection_of: BFO:0000050 UBERON:0001723 ! part of tongue property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0004652 name: humerus diaphysis def: "The body or shaft of the humerus is almost cylindrical in the upper half of its extent, prismatic and flattened below, and has three borders and three surfaces." [Wikipedia:Body_of_humerus] subset: pheno_slim synonym: "body of humerus" EXACT [FMA:13305] synonym: "body of the humerus" RELATED [Wikipedia:Body_of_humerus] synonym: "corpus humeri" EXACT OMO:0003011 [FMA:13305, FMA:TA] synonym: "diaphysis of humerus" EXACT [FMA:13305] synonym: "humeral diaphysis" EXACT [FMA:13305] synonym: "medial humerus" RELATED [Wikipedia:Body_of_humerus] synonym: "shaft of humerus" EXACT [FMA:13305] synonym: "shaft of the humerus" RELATED [Wikipedia:Body_of_humerus] xref: EMAPA:25051 xref: FMA:13305 xref: MA:0002807 xref: NCIT:C120671 xref: SCTID:181927007 xref: Wikipedia:Body_of_humerus is_a: UBERON:0004769 ! diaphysis intersection_of: UBERON:0004769 ! diaphysis intersection_of: BFO:0000050 UBERON:0000976 ! part of humerus relationship: BFO:0000050 UBERON:0000976 ! part of humerus [Term] id: UBERON:0004663 name: aorta wall def: "An anatomical wall that is part of an aorta, enclosing the luminal space." [http://orcid.org/0000-0002-6601-2165] subset: pheno_slim synonym: "aortic wall" EXACT [FMA:14156] synonym: "wall of aorta" EXACT [FMA:14156] xref: EMAPA:35139 xref: FMA:14156 xref: MA:0002901 is_a: UBERON:0035965 ! wall of blood vessel intersection_of: UBERON:0000060 ! anatomical wall intersection_of: BFO:0000050 UBERON:0000947 ! part of aorta relationship: BFO:0000050 UBERON:0000947 ! part of aorta relationship: RO:0002433 UBERON:0000947 ! contributes to morphology of aorta property_value: skos:prefLabel "aorta wall" xsd:string [Term] id: UBERON:0004664 name: aorta tunica adventitia def: "The outermost layer of the aorta wall, containing connective tissue and collagen and elastic fibers." [ISBN:0-683-40008-8, MP:0009871] subset: pheno_slim synonym: "tunica adventitia of aorta" EXACT [FMA:14283] xref: EMAPA:35136 xref: FMA:14283 xref: MA:0002902 xref: SCTID:24996002 is_a: UBERON:0005734 ! tunica adventitia of blood vessel intersection_of: UBERON:0005734 ! tunica adventitia of blood vessel intersection_of: BFO:0000050 UBERON:0000947 ! part of aorta relationship: BFO:0000050 UBERON:0004663 ! part of aorta wall relationship: RO:0002433 UBERON:0004663 ! contributes to morphology of aorta wall property_value: skos:prefLabel "aorta tunica adventitia" xsd:string [Term] id: UBERON:0004665 name: muscular coat of seminal vesicle def: "A muscular coat that is part of a seminal vesicle [Automatically generated definition]." [OBOL:automatic] synonym: "muscle layer of seminal vesicle" EXACT [FMA:19404] synonym: "muscular coat of seminal gland" EXACT [FMA:19404] synonym: "muscular layer of seminal gland" EXACT [FMA:19404] synonym: "tunica muscularis (vesicula seminalis)" EXACT [FMA:19404] synonym: "tunica muscularis glandulae vesiculosae" EXACT OMO:0003011 [FMA:19404, FMA:TA] xref: EMAPA:29773 xref: FMA:19404 xref: MA:0002913 is_a: UBERON:0005156 ! reproductive structure is_a: UBERON:0006660 ! muscular coat intersection_of: UBERON:0006660 ! muscular coat intersection_of: BFO:0000050 UBERON:0000998 ! part of seminal vesicle relationship: BFO:0000050 UBERON:0000998 ! part of seminal vesicle [Term] id: UBERON:0004666 name: interventricular septum membranous part def: "The membranous portion of the wall between the two lower chambers of the heart." [MP:0008823] subset: pheno_slim synonym: "cardiac ventricular membranous septum" EXACT [http://orcid.org/0000-0002-6601-2165] synonym: "membranous interventricular septum" EXACT [FMA:7135] synonym: "membranous interventricular septum" RELATED [MA:0002939] synonym: "membranous part interventricular septum" EXACT [VHOG:0000927] synonym: "membranous part of interventricular septum" EXACT [FMA:7135] synonym: "membranous portion of interventricular septum" EXACT [FMA:7135] synonym: "membranous septum" BROAD [GO:0003149] synonym: "pars membranacea (septi interventricularis)" EXACT [FMA:7135] synonym: "pars membranacea septi interventricularis" EXACT OMO:0003011 [FMA:7135, FMA:TA] synonym: "ventricle membranous septum" BROAD [VT:0000018] synonym: "ventricular membranous septum" BROAD [MP:0008823] xref: EHDAA2:0004596 xref: EMAPA:18246 xref: FMA:7135 xref: MA:0002939 xref: SCTID:278228007 xref: VHOG:0000927 is_a: BFO:0000002 is_a: UBERON:0000158 ! membranous layer is_a: UBERON:0005983 ! heart layer intersection_of: UBERON:0000158 ! membranous layer intersection_of: BFO:0000050 UBERON:0002094 ! part of interventricular septum relationship: BFO:0000050 UBERON:0002094 ! part of interventricular septum relationship: RO:0002202 UBERON:0000095 {source="Wikipedia"} ! develops from cardiac neural crest relationship: RO:0002433 UBERON:0002094 ! contributes to morphology of interventricular septum property_value: skos:prefLabel "interventricular septum membranous part" xsd:string [Term] id: UBERON:0004667 name: interventricular septum muscular part def: "The muscular portion of the wall between the two lower chambers of the heart." [http://orcid.org/0000-0002-6601-2165, Wikipedia:Interventricular_septum#Portions] subset: pheno_slim synonym: "cardiac ventricular muscular septum" EXACT [http://orcid.org/0000-0002-6601-2165] synonym: "muscular interventricular septum" EXACT [FMA:7134] synonym: "muscular interventricular septum" RELATED [MA:0002940] synonym: "muscular part interventricular septum" EXACT [] synonym: "muscular part of interventricular septum" EXACT [FMA:7134] synonym: "muscular septum" BROAD [GO:0003150] synonym: "pars muscularis (septi interventricularis)" EXACT [FMA:7134] synonym: "pars muscularis septi interventricularis" EXACT OMO:0003011 [FMA:7134, FMA:TA] synonym: "septum membranaceum" EXACT OMO:0003011 [] synonym: "ventricular muscular septum" EXACT [] xref: EHDAA2:0000885 xref: EHDAA:2607 xref: EMAPA:18247 xref: FMA:7134 xref: MA:0002940 xref: RETIRED_EHDAA2:0000888 is_a: UBERON:0002385 ! muscle tissue intersection_of: UBERON:0002385 ! muscle tissue intersection_of: BFO:0000050 UBERON:0002094 ! part of interventricular septum relationship: BFO:0000050 UBERON:0002094 ! part of interventricular septum relationship: RO:0002433 UBERON:0002094 ! contributes to morphology of interventricular septum property_value: skos:prefLabel "interventricular septum muscular part" xsd:string [Term] id: UBERON:0004668 name: fourth ventricle aperture def: "One of: the 4th ventricle median or lateral apertures." [https://orcid.org/0000-0002-6601-2165] synonym: "aperture of 4th ventricle" EXACT [] synonym: "aperture of fourth ventricle" EXACT [FMA:242766] xref: FMA:242766 xref: MA:0002945 is_a: UBERON:0000161 ! orifice intersection_of: UBERON:0000161 ! orifice intersection_of: BFO:0000050 UBERON:0002422 ! part of fourth ventricle relationship: BFO:0000050 UBERON:0002422 ! part of fourth ventricle property_value: skos:prefLabel "fourth ventricle aperture" xsd:string [Term] id: UBERON:0004670 name: ependyma def: "The thin epithelium-like membrane composed of ependymal cells that lines the ventricular system of the brain and the spinal cord." [http://orcid.org/0000-0002-6601-2165, ISBN:0387949542, Wikipedia:Ependyma] subset: pheno_slim synonym: "ependyma of neuraxis" EXACT [FMA:242791] synonym: "ependymal epithelium" EXACT [BTO:0000401] synonym: "lamina epithelialis" RELATED [FMA:242791] xref: BTO:0000401 xref: EMAPA:37865 {source="MA:th"} xref: FMA:242791 xref: GAID:608 xref: MESH:D004805 xref: NCIT:C13078 xref: neuronames:1856 xref: SCTID:12766003 xref: UMLS:C0014472 {source="ncithesaurus:Ependyma"} xref: Wikipedia:Ependyma is_a: UBERON:0007601 ! ciliated epithelium is_a: UBERON:0010371 ! ecto-epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: RO:0002473 CL:0000065 ! composed primarily of ependymal cell relationship: BFO:0000050 UBERON:0005358 ! part of ventricle of nervous system relationship: RO:0002202 UBERON:0004060 ! develops from neural tube ventricular layer relationship: RO:0002433 UBERON:0001016 ! contributes to morphology of nervous system relationship: RO:0002473 CL:0000065 ! composed primarily of ependymal cell property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/b/b6/Gray667.png" xsd:anyURI property_value: skos:prefLabel "ependyma" xsd:string [Term] id: UBERON:0004673 name: trigeminal nerve root def: "A nerve root that extends_fibers_into a trigeminal nerve." [OBOL:automatic] synonym: "descending trigeminal root" RELATED [TAO:0000192] synonym: "radix descendens nervi trigemini" EXACT OMO:0003011 [ZFA:0000192] synonym: "root of trigeminal nerve" EXACT [FMA:52610] synonym: "root of trigeminal V nerve" EXACT [Obol:cjm] synonym: "trigeminal nerve root" EXACT [BIRNLEX:1346] synonym: "trigeminal neural root" EXACT [FMA:52610] xref: BIRNLEX:1346 xref: DHBA:12865 xref: DMBA:17739 xref: FMA:52610 xref: HBA:9322 xref: SCTID:280185007 xref: TAO:0000192 xref: ZFA:0000192 is_a: UBERON:0006843 {source="FMA"} ! root of cranial nerve intersection_of: UBERON:0002211 ! nerve root intersection_of: extends_fibers_into UBERON:0001645 ! trigeminal nerve relationship: BFO:0000050 UBERON:0001895 ! part of metencephalon relationship: extends_fibers_into UBERON:0001645 ! trigeminal nerve property_value: IAO:0000116 "TODO - check ZFA" xsd:string property_value: skos:prefLabel "trigeminal nerve root" xsd:string [Term] id: UBERON:0004674 name: facial nerve root def: "A nerve root that extends_fibers_into a facial nerve." [OBOL:automatic] synonym: "central part of facial nerve" EXACT [FMA:53418] synonym: "facial nerve fibers" EXACT [FMA:53418] synonym: "facial nerve or its root" RELATED [BAMS:7n] synonym: "facial nerve root" EXACT [BIRNLEX:1513] synonym: "facial nerve/root" RELATED [BAMS:7n] synonym: "facial neural root" EXACT [FMA:53418] synonym: "fibrae nervi facialis" EXACT OMO:0003011 [FMA:53418, FMA:TA] synonym: "root of facial nerve" EXACT [FMA:53418] xref: BAMS:7n xref: BAMS:7nf xref: BIRNLEX:1513 xref: DHBA:12862 xref: DMBA:17742 xref: FMA:53418 xref: neuronames:579 xref: SCTID:280186008 is_a: UBERON:0006843 {source="FMA"} ! root of cranial nerve intersection_of: UBERON:0002211 ! nerve root intersection_of: extends_fibers_into UBERON:0001647 ! facial nerve relationship: BFO:0000050 UBERON:0001895 ! part of metencephalon relationship: extends_fibers_into UBERON:0001647 ! facial nerve property_value: skos:prefLabel "facial nerve root" xsd:string [Term] id: UBERON:0004675 name: hypoglossal nerve root def: "A nerve root that extends_fibers_into a hypoglossal nerve." [OBOL:automatic] synonym: "central part of hypoglossal nerve" EXACT [FMA:72632] synonym: "central part of hypoglossal nerve" RELATED [BIRNLEX:1288] synonym: "fibrae nervi hypoglossi" EXACT OMO:0003011 [FMA:72632, FMA:TA] synonym: "hypoglossal nerve fiber bundle" EXACT HUMAN_PREFERRED [BIRNLEX:1288] synonym: "hypoglossal nerve fibers" EXACT [FMA:72632] synonym: "hypoglossal nerve fibers" RELATED [BIRNLEX:1288] synonym: "hypoglossal nerve root" EXACT [BIRNLEX:1588] synonym: "hypoglossal nerve tract" EXACT [FMA:72632] synonym: "hypoglossal nerve/ root" RELATED [BAMS:12n] synonym: "root of hypoglossal nerve" EXACT [FMA:72632] synonym: "root of hypoglossal nerve" RELATED [BIRNLEX:1288] xref: BAMS:12n xref: BAMS:12nf xref: BIRNLEX:1288 xref: BIRNLEX:1588 xref: DHBA:12886 xref: DMBA:17750 xref: FMA:72632 xref: HBA:9343 xref: neuronames:798 xref: UMLS:C0175555 is_a: UBERON:0006843 {source="FMA"} ! root of cranial nerve intersection_of: UBERON:0002211 ! nerve root intersection_of: extends_fibers_into UBERON:0001650 ! hypoglossal nerve relationship: BFO:0000050 UBERON:0001896 ! part of medulla oblongata relationship: extends_fibers_into UBERON:0001650 ! hypoglossal nerve property_value: skos:prefLabel "hypoglossal nerve root" xsd:string [Term] id: UBERON:0004679 name: dentate gyrus molecular layer def: "The molecular layer of the dentate gyrus that is bounded by the pial surface superficially and the dentate gyrus granule cell layer deep. It is divided into 2 or more sublayers." [BIRNLEX:4127] synonym: "dentate gyrus molecular layer" EXACT [BIRNLEX:4127] synonym: "molecular layer of dentate gyrus" EXACT [FMA:83677] synonym: "molecular layer of the dentate gyrus" RELATED [BAMS:Mol] synonym: "stratum moleculare gyri dentati" EXACT OMO:0003011 [FMA:83677, FMA:TA] xref: BAMS:mo xref: BAMS:Mol xref: BIRNLEX:4127 xref: EMAPA:35279 xref: FMA:83677 xref: MA:0003122 xref: MBA:10703 xref: neuronames:2121 is_a: UBERON:0002304 ! layer of dentate gyrus intersection_of: UBERON:0002304 ! layer of dentate gyrus intersection_of: RO:0002007 UBERON:0001885 ! bounding layer of dentate gyrus of hippocampal formation relationship: BFO:0000051 GO:0030425 ! has part dendrite relationship: BFO:0000051 UBERON:0006134 ! has part nerve fiber relationship: BSPO:0001107 UBERON:0002361 ! pia mater relationship: RO:0002007 UBERON:0001885 ! bounding layer of dentate gyrus of hippocampal formation property_value: skos:prefLabel "dentate gyrus molecular layer" xsd:string [Term] id: UBERON:0004681 name: vestibular system def: "The sensory system for the sense of balance." [NLXANAT:090819] subset: pheno_slim synonym: "equilibrioception system" NARROW [] synonym: "vestibular organ system" EXACT [FMA:7193] synonym: "vestibular system" EXACT [NLXANAT:090819] synonym: "vestibulomotor system" NARROW [] xref: BTO:0003381 xref: EMAPA:37986 {source="MA:th"} xref: FMA:7193 xref: NLXANAT:090819 xref: SCTID:361533001 xref: Wikipedia:Vestibular_system is_a: UBERON:0001032 ! sensory system intersection_of: UBERON:0001032 ! sensory system intersection_of: RO:0002215 GO:0050957 ! capable of equilibrioception relationship: BFO:0000050 UBERON:0002105 ! part of vestibulo-auditory system relationship: RO:0002215 GO:0050957 ! capable of equilibrioception relationship: RO:0002216 GO:0060005 ! capable of part of vestibular reflex property_value: skos:prefLabel "vestibular system" xsd:string [Term] id: UBERON:0004684 name: raphe nuclei def: "The raphe nuclei are thin plates of cells in and immediately adjacent to the sagittal plane." [https://sourceforge.net/tracker/?func=detail&aid=3248146&group_id=36855&atid=440764, NLXANAT:20090205] comment: we treat NR obscurus, NR magnus etc as parts of the raphe nuclei. This is consistent with treatment in FMA, where the class is 'set of raphe nuclei' subset: vertebrate_core synonym: "nuclei raphes" EXACT OMO:0003011 [FMA:84017, FMA:TA] synonym: "nuclei raphes" RELATED OMO:0003011 [Wikipedia:Raphe_nuclei] synonym: "raphe cluster" RELATED [Wikipedia:Raphe_nuclei] synonym: "raphe nuclei" EXACT [FMA:84017, NLXANAT:20090205] synonym: "raphe nuclei set" EXACT [FMA:84017] synonym: "raphe nucleus" RELATED [ZFA:0001429] synonym: "raphe of mesenchephalon" RELATED [BAMS:RA] synonym: "set of raphe nuclei" RELATED [FMA:84017] xref: BAMS:RA xref: EMAPA:35721 xref: FMA:84017 xref: MA:0003147 xref: MESH:D011903 xref: NCIT:C97335 xref: neuronames:2495 xref: NLXANAT:20090205 xref: TAO:0001429 xref: UMLS:C0034671 {source="ncithesaurus:Raphe_Nuclei"} xref: Wikipedia:Raphe_nuclei xref: ZFA:0001429 is_a: UBERON:0002616 ! regional part of brain relationship: BFO:0000050 UBERON:0002275 {source="GO", source="Wikipedia"} ! part of reticular formation relationship: RO:0002215 GO:0001820 {source="Wikipedia"} ! capable of serotonin secretion property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/9/94/Gray694.png" xsd:anyURI property_value: skos:prefLabel "raphe nuclei" xsd:string [Term] id: UBERON:0004688 name: costo-cervical trunk def: "The costocervical trunk arises from the upper and back part of the subclavian artery, behind the scalenus anterior on the right side, and medial to that muscle on the left side. Passing backward, it splits into the deep cervical artery and the supreme intercostal artery (or the Highest intercostal artery), which descends behind the pleura in front of the necks of the first and second ribs, and anastomoses with the first aortic intercostal (3rd posterior intercostal artery). As it crosses the neck of the first rib it lies medial to the anterior division of the first thoracic nerve, and lateral to the first thoracic ganglion of the sympathetic trunk. In the first intercostal space, it gives off a branch which is distributed in a manner similar to the distribution of the aortic intercostals. The branch for the second intercostal space usually joins with one from the highest aortic intercostal artery. This branch is not constant, but is more commonly found on the right side; when absent, its place is supplied by an intercostal branch from the aorta. Each intercostal gives off a posterior branch which goes to the posterior vertebral muscles, and sends a small spinal branch through the corresponding intervertebral foramen to the medulla spinalis and its membranes. [WP,unvetted]." [Wikipedia:Costocervical_trunk] subset: human_reference_atlas synonym: "costocervical trunk" EXACT [FMA:10636] synonym: "truncus costocervicalis" RELATED OMO:0003011 [Wikipedia:Costocervical_trunk] synonym: "trunk of costocervical artery" EXACT [FMA:10636] xref: EMAPA:37496 {source="MA:th"} xref: FMA:10636 xref: MA:0001939 xref: SCTID:244225009 xref: Wikipedia:Costocervical_trunk is_a: UBERON:0001637 ! artery relationship: RO:0002170 UBERON:0001533 ! connected to subclavian artery property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/b/b3/Costocervical_trunk_with_branches.png" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "costo-cervical trunk" xsd:string [Term] id: UBERON:0004692 name: external naris epithelium def: "An epithelium that is part of an external naris [Automatically generated definition]." [OBOL:automatic] xref: EMAPA:18596 xref: MA:0001321 is_a: UBERON:0019306 ! nose epithelium is_a: UBERON:0035036 ! naris epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: BFO:0000050 UBERON:0005928 ! part of external naris relationship: BFO:0000050 UBERON:0005928 ! part of external naris [Term] id: UBERON:0004693 name: Peyer's patch epithelium def: "The specialized epithelial layer covering the entire Peyer's patch, including both the follicular and interfollicular areas and forming part of the gut-associated lymphoid tissue." [ISBN:0-8153-1691-7, MGI:cwg, MP:0002388] subset: pheno_slim synonym: "Peyer's patch epithelium" EXACT [MA:0000731, PMID:31813624] xref: EMAPA:36506 xref: MA:0000731 is_a: UBERON:0001277 ! intestinal epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: BFO:0000050 UBERON:0001211 ! part of Peyer's patch relationship: BFO:0000050 UBERON:0001211 ! part of Peyer's patch relationship: RO:0002433 UBERON:0001211 ! contributes to morphology of Peyer's patch [Term] id: UBERON:0004695 name: arterial system smooth muscle def: "A portion of smooth muscle tissue that is part of an arterial system [Automatically generated definition]." [OBOL:automatic] xref: EMAPA:36503 xref: MA:0000704 is_a: UBERON:0001135 ! smooth muscle tissue intersection_of: UBERON:0001135 ! smooth muscle tissue intersection_of: BFO:0000050 UBERON:0004572 ! part of arterial system relationship: BFO:0000050 UBERON:0004572 ! part of arterial system property_value: skos:prefLabel "arterial system smooth muscle" xsd:string [Term] id: UBERON:0004696 name: venous system smooth muscle def: "A portion of smooth muscle tissue that is part of a venous system [Automatically generated definition]." [OBOL:automatic] xref: EMAPA:36613 xref: MA:0000715 is_a: UBERON:0004237 ! blood vessel smooth muscle intersection_of: UBERON:0001135 ! smooth muscle tissue intersection_of: BFO:0000050 UBERON:0004582 ! part of venous system relationship: BFO:0000050 UBERON:0004237 ! part of blood vessel smooth muscle relationship: BFO:0000050 UBERON:0004582 ! part of venous system property_value: skos:prefLabel "venous system smooth muscle" xsd:string [Term] id: UBERON:0004697 name: Peyer's patch germinal center def: "Area of the Peyer's patch where B cells proliferate and differentiate into plasma cells." [MP:0002391] subset: pheno_slim xref: EMAPA:35684 xref: MA:0000734 xref: NCIT:C49600 xref: UMLS:C1711398 {source="ncithesaurus:Peyer_s_Patch_Germinal_Center"} is_a: UBERON:0010754 ! germinal center intersection_of: UBERON:0010754 ! germinal center intersection_of: BFO:0000050 UBERON:0001211 ! part of Peyer's patch relationship: BFO:0000050 UBERON:0001211 ! part of Peyer's patch relationship: BFO:0000067 GO:0002317 ! contains process plasma cell differentiation relationship: BFO:0000067 GO:0042100 ! contains process B cell proliferation [Term] id: UBERON:0004698 name: vena cava endothelium def: "An endothelium that is part of a vena cava [Automatically generated definition]." [OBOL:automatic] xref: EMAPA:37800 {source="MA:th"} xref: MA:0000713 xref: NCIT:C49318 xref: UMLS:C1710623 {source="ncithesaurus:Vena_Cava_Endothelium"} is_a: UBERON:0001919 ! endothelium of vein intersection_of: UBERON:0001986 ! endothelium intersection_of: BFO:0000050 UBERON:0004087 ! part of vena cava relationship: BFO:0000050 UBERON:0004087 ! part of vena cava property_value: skos:prefLabel "vena cava endothelium" xsd:string [Term] id: UBERON:0004699 name: outflow tract endothelium def: "An endothelium that is part of a outflow tract [Automatically generated definition]." [OBOL:automatic] xref: MA:0000490 xref: VHOG:0001524 is_a: UBERON:0008307 ! heart endothelium intersection_of: UBERON:0001986 ! endothelium intersection_of: BFO:0000050 UBERON:0004145 ! part of outflow tract relationship: BFO:0000050 UBERON:0004145 ! part of outflow tract property_value: skos:prefLabel "outflow tract endothelium" xsd:string [Term] id: UBERON:0004700 name: arterial system endothelium def: "An endothelium that is part of an arterial system [Automatically generated definition]." [OBOL:automatic] xref: EMAPA:35145 xref: MA:0000703 xref: NCIT:C49329 xref: UMLS:C1706849 {source="ncithesaurus:Arterial_System_Endothelium"} is_a: UBERON:0004852 ! cardiovascular system endothelium intersection_of: UBERON:0001986 ! endothelium intersection_of: BFO:0000050 UBERON:0004572 ! part of arterial system relationship: BFO:0000050 UBERON:0004572 ! part of arterial system property_value: skos:prefLabel "arterial system endothelium" xsd:string [Term] id: UBERON:0004701 name: venous system endothelium def: "An endothelium that is part of a venous system [Automatically generated definition]." [OBOL:automatic] xref: EMAPA:35907 xref: MA:0000714 xref: NCIT:C49320 xref: UMLS:C1710626 {source="ncithesaurus:Venous_System_Endothelium"} is_a: UBERON:0004852 ! cardiovascular system endothelium intersection_of: UBERON:0001986 ! endothelium intersection_of: BFO:0000050 UBERON:0004582 ! part of venous system relationship: BFO:0000050 UBERON:0004582 ! part of venous system property_value: skos:prefLabel "venous system endothelium" xsd:string [Term] id: UBERON:0004702 name: respiratory system blood vessel endothelium def: "A blood vessel endothelium that is part of a respiratory system [Automatically generated definition]." [OBOL:automatic] xref: EMAPA:35732 xref: MA:0001805 is_a: UBERON:0004638 ! blood vessel endothelium is_a: UBERON:0004807 ! respiratory system epithelium intersection_of: UBERON:0004638 ! blood vessel endothelium intersection_of: BFO:0000050 UBERON:0001004 ! part of respiratory system relationship: BFO:0000050 UBERON:0003504 ! part of respiratory system blood vessel property_value: skos:prefLabel "respiratory system blood vessel endothelium" xsd:string [Term] id: UBERON:0004703 name: dorsal thalamus subset: human_reference_atlas subset: pheno_slim subset: vertebrate_core synonym: "dorsal thalamus" EXACT [FMA:62007] synonym: "dorsal thalamus (Anthoney)" EXACT [FMA:62007] synonym: "dorsal tier of thalamus" RELATED [DMBA:DTTh] synonym: "thalamus dorsalis" EXACT OMO:0003011 [BTO:0001365, Wikipedia:Thalamus] synonym: "thalamus proper" EXACT [PMCID:PMC3345571] synonym: "thalamus, pars dorsalis" EXACT [ZFA:0000653] xref: BAMS:DOR xref: BAMS:Dorsal_thalamus xref: BM:Die-Th xref: DHBA:10391 xref: DMBA:16396 xref: EHDAA2:0000692 xref: EMAPA:35295 xref: FMA:62007 xref: HBA:4393 xref: MA:0000180 xref: ncithesaurus:Dorsal_Thalamus xref: neuronames:1455 xref: PBA:128013018 xref: TAO:0000653 xref: ZFA:0000653 is_a: UBERON:0002616 ! regional part of brain relationship: BFO:0000050 UBERON:0001897 ! part of dorsal plus ventral thalamus property_value: IAO:0000116 "TODO. http://www.ncbi.nlm.nih.gov/pubmed/8167659" xsd:string property_value: RO:0002175 NCBITaxon:117569 {source="Ariens, p. 1192"} property_value: RO:0002175 NCBITaxon:7742 property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "dorsal thalamus" xsd:string [Term] id: UBERON:0004704 name: bone fossa def: "A depression or hollow in a bone[WP]." [Wikipedia:Fossa#Anatomy] subset: vertebrate_core synonym: "concavities" RELATED OMO:0003004 [TAO:0001743] synonym: "concavity" RELATED [TAO:0001743] synonym: "depression" RELATED [TAO:0001743] synonym: "depressions" RELATED OMO:0003004 [TAO:0001743] synonym: "fossa" BROAD [] synonym: "fossae" RELATED OMO:0003004 [TAO:0001743] synonym: "groove" RELATED [TAO:0001743] xref: AAO:0010439 xref: FMA:45791 xref: TAO:0001743 xref: UMLS:C0836913 {source="ncithesaurus:Fossa"} xref: VSAO:0005069 xref: Wikipedia:Fossa#Anatomy xref: ZFA:0005388 is_a: UBERON:0002553 {source="FMA-implied"} ! anatomical cavity relationship: BFO:0000050 UBERON:0001474 ! part of bone element [Term] id: UBERON:0004706 name: bulbus cordis def: "A transient fetal dilation of the distal (or cranial) heart tube located where the arterial trunk joins the ventral roots of the aortic arches." [ISBN:0-683-40008-8, MP:0010568] subset: pheno_slim subset: vertebrate_core synonym: "primitive right ventricle endocardium" EXACT [EHDAA2:0000197] xref: EHDAA2:0000197 xref: EHDAA:438 xref: EHDAA:768 xref: EMAPA:16333 xref: FMA:70300 xref: NCIT:C34114 xref: SCTID:361525002 xref: UMLS:C1284055 {source="ncithesaurus:Bulbus_Cordis"} xref: Wikipedia:Bulbus_cordis is_a: UBERON:0002050 ! embryonic structure relationship: BFO:0000050 UBERON:0000948 ! part of heart property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/c/c9/Gray466.png" xsd:anyURI property_value: IAO:0000116 "TODO - check relationship to bulbus arteriosus" xsd:string property_value: skos:prefLabel "bulbus cordis" xsd:string [Term] id: UBERON:0004707 name: pharyngula stage def: "A chordate developmental stage that follows the blastula, gastrula and neurula stages. At the pharyngula stage, all vertebrate embryos show remarkable similarities." [Wikipedia:Pharyngula] subset: efo_slim synonym: "pharyngula" RELATED [] synonym: "phylotypic stage" EXACT [] xref: DrerDO:0000052 xref: EFO:0001310 xref: OGES:000006 xref: Wikipedia:Pharyngula xref: ZFS:0000050 is_a: BFO:0000003 is_a: UBERON:0000105 ! life cycle stage relationship: BFO:0000050 UBERON:0000111 ! part of organogenesis stage relationship: BFO:0000062 UBERON:0000110 ! preceded by neurula stage relationship: RO:0002162 NCBITaxon:7711 ! in taxon Chordata [Term] id: UBERON:0004708 name: paired limb/fin def: "An appendage that is part of an appendage girdle complex." [https://github.com/geneontology/go-ontology/issues/9029, UBERON:cjm] subset: homology_grouping synonym: "girdle-associated appendage" EXACT [https://orcid.org/0000-0002-6601-2165] synonym: "jointed paired lateral appendage" NARROW [https://orcid.org/0000-0002-6601-2165] synonym: "limb or fin" EXACT [https://orcid.org/0000-0002-6601-2165] synonym: "limb/fin" EXACT [https://orcid.org/0000-0002-6601-2165] synonym: "paired appendage" NARROW [VSAO:0000067] synonym: "pectoral or pelvic appendage" EXACT [https://orcid.org/0000-0002-6601-2165] synonym: "pelvic/pectoral appendage" EXACT [https://orcid.org/0000-0002-6601-2165] xref: VSAO:0000067 is_a: UBERON:0000026 {source="VSAO"} ! appendage is_a: UBERON:0010314 ! structure with developmental contribution from neural crest intersection_of: UBERON:0000026 ! appendage intersection_of: BFO:0000050 UBERON:0010707 ! part of appendage girdle complex relationship: BFO:0000050 UBERON:0010707 {source="VSAO"} ! part of appendage girdle complex relationship: BFO:0000051 UBERON:0000014 ! has part zone of skin relationship: BFO:0000051 UBERON:0001015 ! has part musculature relationship: BFO:0000051 UBERON:0002049 ! has part vasculature relationship: RO:0002170 UBERON:0007823 ! connected to appendage girdle region relationship: RO:0002202 UBERON:0004357 {evidence="definitional"} ! develops from paired limb/fin bud relationship: RO:0002551 UBERON:0011582 ! has skeleton paired limb/fin skeleton property_value: skos:prefLabel "paired limb/fin" xsd:string [Term] id: UBERON:0004709 name: pelvic appendage def: "Paired appendage that consists of the posterior appendicular skeleton and associated soft and hard tissues, but excludes the pelvic girdle and its associated soft and hard tissues." [VSAO:0000150] subset: homology_grouping synonym: "hindlimb/pelvic fin" EXACT [https://orcid.org/0000-0002-6601-2165] synonym: "pelvic appendage" EXACT [VSAO:0000126] synonym: "pelvic limb/fin" EXACT [https://orcid.org/0000-0002-6601-2165] synonym: "posterior appendage" BROAD [] synonym: "posterior limb/fin" EXACT [] synonym: "posterior paired appendage" EXACT [VSAO:0000126] xref: VSAO:0000126 is_a: UBERON:0004708 ! paired limb/fin intersection_of: UBERON:0004708 ! paired limb/fin intersection_of: BFO:0000050 UBERON:0010709 ! part of pelvic complex disjoint_from: UBERON:0004710 {source="lexical"} ! pectoral appendage relationship: BFO:0000050 UBERON:0010709 ! part of pelvic complex relationship: RO:0002170 UBERON:0001271 ! connected to pelvic girdle region relationship: RO:0002202 UBERON:0005420 {evidence="definitional"} ! develops from pelvic appendage bud relationship: RO:0002551 UBERON:0007273 ! has skeleton pelvic appendage skeleton [Term] id: UBERON:0004710 name: pectoral appendage def: "Paired appendage that consists of the anterior appendicular skeleton and associated soft and hard tissues, but excludes the pectoral girdle and its associated soft and hard tissues." [VSAO:0000150-modified] subset: homology_grouping synonym: "anterior appendage" BROAD [] synonym: "anterior limb/fin" EXACT [https://orcid.org/0000-0002-6601-2165] synonym: "anterior paired appendage" EXACT [VSAO:0000148] synonym: "forelimb - pectoral fin" EXACT [VHOG:0001753] synonym: "forelimb or pectoral fin" EXACT [https://orcid.org/0000-0002-6601-2165] synonym: "forelimb/pectoral fin" EXACT [https://orcid.org/0000-0002-6601-2165] synonym: "pectoral limb/fin" EXACT [https://orcid.org/0000-0002-6601-2165] xref: VHOG:0001753 xref: VSAO:0000125 is_a: UBERON:0004708 ! paired limb/fin intersection_of: UBERON:0004708 ! paired limb/fin intersection_of: BFO:0000050 UBERON:0010708 ! part of pectoral complex relationship: BFO:0000050 UBERON:0010708 ! part of pectoral complex relationship: RO:0002170 UBERON:0001421 ! connected to pectoral girdle region relationship: RO:0002202 UBERON:0005419 {evidence="definitional"} ! develops from pectoral appendage bud relationship: RO:0002551 UBERON:0007272 ! has skeleton pectoral appendage skeleton property_value: skos:prefLabel "pectoral appendage" xsd:string [Term] id: UBERON:0004711 name: jugular vein def: "The jugular veins are veins that bring deoxygenated blood from the head back to the heart via the superior vena cava." [Wikipedia:Jugular_vein] synonym: "jugular" RELATED [] synonym: "vena jugularis" RELATED [BTO:0001744] xref: BTO:0001744 xref: CALOHA:TS-0497 xref: EMAPA:18638 xref: GAID:536 xref: MA:0002154 xref: MESH:D007601 xref: NCIT:C12738 xref: SCTID:244403000 xref: UMLS:C0022427 {source="ncithesaurus:Jugular_Vein"} xref: Wikipedia:Jugular_vein is_a: UBERON:0001638 ! vein relationship: RO:0020102 UBERON:0000033 ! vessel drains blood from head property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/f/f8/Gray558.png" xsd:anyURI property_value: skos:prefLabel "jugular vein" xsd:string [Term] id: UBERON:0004715 name: annulus fibrosus disci intervertebralis def: "The ring of fibrocartilage and fibrous tissue forming the circumference of the intervertebral disc; surrounds the nucleus pulposus, which is prone to herniation when the annulus fibrosus is compromised." [BTO:0003629, Wikipedia:Annulus_fibrosus_disci_intervertebralis] synonym: "annulus fibrosus" BROAD [MA:0000111] synonym: "annulus fibrosus of intervertebral disc" RELATED [BTO:0003629] synonym: "anulus fibrosus (diskus intervertebralis)" EXACT [FMA:13551] synonym: "anulus fibrosus of intervertebral disk" EXACT [FMA:13551] synonym: "fibrous ring of intervertebral disc" RELATED [BTO:0003629] xref: BTO:0003629 xref: EMAPA:32670 xref: FMA:13551 xref: MA:0000111 xref: Wikipedia:Annulus_fibrosus_disci_intervertebralis is_a: UBERON:0006444 ! annulus fibrosus intersection_of: UBERON:0006444 ! annulus fibrosus intersection_of: BFO:0000050 UBERON:0001066 ! part of intervertebral disk disjoint_from: UBERON:0006008 ! fibrous ring of heart relationship: BFO:0000050 UBERON:0001066 ! part of intervertebral disk property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/d/d9/Cervical_vertebra_english.png" xsd:anyURI [Term] id: UBERON:0004716 name: conceptus def: "The embryo and its adnexa (appendages or adjunct parts) or associated membranes (i.e. the products of conception) The conceptus includes all structures that develop from the zygote, both embryonic and extraembryonic. It includes the embryo as well as the embryonic part of the placenta and its associated membranes - amnion, chorion (gestational sac), and yolk sac[WP]." [BTO:0003834, Wikipedia:Conceptus] synonym: "embryo plus adnexa" EXACT [] xref: AEO:0000194 xref: BTO:0003834 xref: EHDAA2:0000001 xref: EHDAA2:0003235 xref: EMAPA:36040 xref: NCIT:C34131 xref: UMLS:C1516779 {source="ncithesaurus:Conceptus"} xref: Wikipedia:Conceptus is_a: BFO:0000002 is_a: UBERON:0000061 ! anatomical structure relationship: BFO:0000051 UBERON:0002050 ! has part embryonic structure relationship: BFO:0000051 UBERON:0016887 ! has part entire extraembryonic component relationship: RO:0002202 CL:0000365 ! develops from animal zygote relationship: RO:0002489 UBERON:0000068 ! existence starts with embryo stage relationship: RO:0002493 UBERON:0000068 ! existence ends with embryo stage property_value: IAO:0000116 "EHDAA2 places this as a subtype of organism. This leads to the inference that a conceptus is an embryo (if an embryo is defined as an organism at embryo stage), which eliminates the embryonic + extra-embryonic = conceptus" xsd:string property_value: skos:prefLabel "conceptus" xsd:string [Term] id: UBERON:0004719 name: kidney arcuate vein def: "Any of the veins that parallel the arcuate arteries, receive blood from the interlobular veins and straight venules, and terminate in the interlobar veins." [ISBN:0-683-40008-8, MP:0011325] subset: human_reference_atlas subset: pheno_slim synonym: "arciform vein of kidney" EXACT [MP:0011325] synonym: "arcuate vein" BROAD [MA:0002593] synonym: "arcuate vein of kidney" EXACT [MP:0011325] synonym: "arcuate veins" RELATED [Wikipedia:Arcuate_vein] synonym: "renal arcuate vein" EXACT [MP:0011325] synonym: "venae arcuatae renis" EXACT OMO:0003011 [Wikipedia:Arcuate_vein] xref: EMAPA:28221 xref: FMA:272193 xref: FMA:321527 xref: MA:0002593 xref: Wikipedia:Arcuate_vein is_a: UBERON:0013126 ! vein of abdomen is_a: UBERON:0014401 ! renal venous blood vessel relationship: RO:0002170 UBERON:0009887 ! connected to interlobar vein property_value: foaf:depiction "https://upload.wikimedia.org/wikipedia/commons/7/7e/Kidney_PioM.png" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0004720 name: cerebellar vermis def: "A subregion of the cerebellar cortex, consisting of the most medial zone of the cerebellar cortex, stradding the midline. May be continuous with the lateral cerebellar hemispheres in some areas of the cerebellum, e.g., dorsally, or separated by deeper fissures in others (e.g., ventrally)." [BIRNLEX:1106] subset: human_reference_atlas subset: pheno_slim synonym: "cerebellum vermis" EXACT [FMA:76928] synonym: "vermal parts of the cerebellum" EXACT [BIRNLEX:1175] synonym: "vermal regions" EXACT [ABA:VERM] synonym: "vermis" RELATED [Wikipedia:Cerebellar_vermis] synonym: "vermis cerebelli" RELATED OMO:0003011 [Wikipedia:Cerebellar_vermis] synonym: "vermis cerebelli [I-X]" EXACT OMO:0003011 [FMA:76928, FMA:TA] synonym: "vermis of cerebellum" EXACT [FMA:76928] synonym: "vermis of cerebellum [I-X]" EXACT [FMA:76928] xref: BAMS:Ver xref: BAMS:VERM xref: BIRNLEX:1106 xref: BIRNLEX:1175 xref: CALOHA:TS-2059 xref: DHBA:10658 xref: DMBA:16814 xref: EMAPA:35214 xref: EV:0100298 xref: FMA:76928 xref: HBA:4698 xref: MA:0000202 xref: MBA:645 xref: NCIT:C33866 xref: neuronames:2463 xref: SCTID:279105006 xref: UMLS:C0228482 {source="BIRNLEX:1106", source="ncithesaurus:Vermis"} xref: Wikipedia:Cerebellar_vermis is_a: UBERON:0002749 ! regional part of cerebellar cortex relationship: BSPO:0005001 UBERON:0002037 ! cerebellum relationship: RO:0002202 UBERON:0004008 ! develops from cerebellar plate relationship: RO:0002216 GO:0040011 ! capable of part of locomotion relationship: RO:0002433 UBERON:0002129 ! contributes to morphology of cerebellar cortex property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/4/43/CerebellumDiv.png" xsd:anyURI property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/brain-female/v1.4/assets/3d-allen-f-brain.glb" xsd:anyURI property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/brain-male/v1.4/assets/3d-allen-m-brain.glb" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "cerebellar vermis" xsd:string [Term] id: UBERON:0004721 name: crista ampullaris def: "The crista ampullaris is the sensory organ of rotation located in the semicircular canal of the inner ear. The function of the crista ampullaris is to sense angular acceleration and deceleration." [Wikipedia:Crista_ampullaris] subset: organ_slim subset: pheno_slim synonym: "ampullary crest" RELATED [MA:0002771] synonym: "ampullary crest of semicircular duct" EXACT [FMA:77714] synonym: "cristae ampullares" RELATED [Wikipedia:Crista_ampullaris] xref: EMAPA:32791 xref: FMA:77714 xref: MA:0002771 xref: NCIT:C32063 xref: SCTID:368953000 xref: UMLS:C0229465 {source="ncithesaurus:Ampullary_Crest"} xref: Wikipedia:Crista_ampullaris is_a: UBERON:0000020 ! sense organ relationship: BFO:0000050 UBERON:0004043 {source="MA"} ! part of semicircular canal ampulla relationship: RO:0002433 UBERON:0004043 ! contributes to morphology of semicircular canal ampulla property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/e/ec/Semicircular_canal_-_ampulla.png" xsd:anyURI [Term] id: UBERON:0004723 name: interlobular artery def: "The branches of the arcuate arteries of the kidney that radiate outward throught the renal columns and supply the glomeruli[MP]. The first set of renal bloodvessels, the interlobular arteries (or cortical radiate arteries, or cortical radial arteries), are given off at right angles from the side of the arcuate arteries looking toward the cortical substance, and pass directly outward between the medullary rays to reach the fibrous tunic, where they end in the capillary network of this part. These vessels do not anastomose with each other, but form what are called end-arteries. In their outward course they give off lateral branches; these are the afferent vessels for the renal corpuscles; they enter the capsule, and end in the glomerulus. From each tuft the corresponding efferent vessel arises, and, having made its egress from the capsule near to the point where the afferent vessel enters, breaks up into a number of branches, which form a dense plexus within Bowman's capsule." [MP:0011316, Wikipedia:Interlobular_arteries] subset: human_reference_atlas subset: pheno_slim synonym: "arteriae corticales radiatae" RELATED OMO:0003011 [Wikipedia:Interlobular_arteries] synonym: "arteriae interlobulares renis" RELATED OMO:0003011 [Wikipedia:Interlobular_arteries] synonym: "cortical radial arteries" RELATED [Wikipedia:Interlobular_arteries] synonym: "interlobular" RELATED [Wikipedia:Interlobular_arteries] synonym: "interlobular renal artery" EXACT [FMA:70498] synonym: "kidney interlobular artery" EXACT [MP:0011316] synonym: "renal interlobular artery" RELATED [FMA:70498] xref: EMAPA:28212 xref: FMA:70498 xref: MA:0002584 xref: NCIT:C32826 xref: SCTID:76147008 xref: UMLS:C1512856 {source="ncithesaurus:Interlobular_Artery"} xref: Wikipedia:Interlobular_arteries is_a: UBERON:0003644 ! kidney arterial blood vessel disjoint_from: UBERON:0009885 {source="Wikipedia:Renal_circulation"} ! interlobar artery relationship: RO:0002170 UBERON:0001552 ! connected to kidney arcuate artery property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/0/02/Gray1128.png" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0004725 name: piriform cortex def: "The subdivision of the laminated olfactory cortex with only three main layers that receive monosynaptic input from the olfactory bulb via the lateral olfactory tract; it is located bilaterally in the ventrolateral forebrain and is commonly divided into anterior and posterior regions." [MP:0010009, PMID:17714095] subset: human_reference_atlas subset: pheno_slim synonym: "area prepiriformis" RELATED OMO:0003011 [NeuroNames:165] synonym: "cortex piriformis" EXACT OMO:0003011 [Wikipedia:Piriform_cortex] synonym: "eupalaeocortex" RELATED OMO:0003011 [NeuroNames:165] synonym: "olfactory pallium" RELATED [ISBN:0471888893] synonym: "palaeocortex II" RELATED OMO:0003011 [NeuroNames:165] synonym: "paleopallium" RELATED [Wikipedia:Piriform_cortex] synonym: "piriform area" RELATED [BTO:0002651, MA:0000978] synonym: "piriform lobe" RELATED [BTO:0002651] synonym: "primary olfactory areas" EXACT [BIRNLEX:2706] synonym: "primary olfactory cortex" RELATED INCONSISTENT [Wikipedia:Piriform_cortex] synonym: "pyriform cortex" RELATED [Wikipedia:Piriform_cortex] synonym: "pyriform lobe" RELATED [Wikipedia:Piriform_cortex] synonym: "regio praepiriformis" RELATED OMO:0003011 [NeuroNames:165] xref: BAMS:PIR xref: BAMS:Pir xref: BIRNLEX:1097 xref: BTO:0002651 xref: DHBA:10311 xref: EMAPA:32767 xref: EV:0100178 xref: HBA:10142 xref: MA:0000978 xref: MESH:D066195 xref: neuronames:165 {source="BIRNLEX:1097"} xref: SCTID:369098004 xref: UMLS:C0228280 {source="BIRNLEX:1097"} xref: Wikipedia:Piriform_cortex is_a: UBERON:0002616 ! regional part of brain relationship: BFO:0000050 UBERON:0002894 ! part of olfactory cortex relationship: RO:0002162 NCBITaxon:32523 {source="Wikipedia"} ! in taxon Tetrapoda relationship: RO:0002433 UBERON:0002894 ! contributes to morphology of olfactory cortex property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/b/b1/Human_brainstem_anterior_view_2_description.JPG" xsd:anyURI property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/brain-female/v1.4/assets/3d-allen-f-brain.glb" xsd:anyURI property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/brain-male/v1.4/assets/3d-allen-m-brain.glb" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "piriform cortex" xsd:string [Term] id: UBERON:0004726 name: vasa recta def: "A group of microvessels that are part of the kidney. A vasa recta has a hairpin-like shape, entering the renal medulla as the straight arterioles and surrounds the loop of Henle, forming a capillary network. Finally it leaves the renal medulla to ascend to the cortex as the straight venules. The primary function of the vasa recta is to facilitate countercurrent exchange, which is essential for the kidney's ability to concentrate urine" [PMID:23126245, Wikipedia:Vasa_recta] subset: human_reference_atlas subset: pheno_slim synonym: "arteriolae rectae renis" NARROW OMO:0003011 [FMA:72006, FMA:TA] synonym: "arteriolae rectae renis" RELATED OMO:0003011 [Wikipedia:Vasa_recta] synonym: "arteriolae recti" RELATED [Wikipedia:Vasa_recta] synonym: "kidney vasa recta" EXACT [MP:0011324] synonym: "renal medullary capillary" NARROW [EMAPA:30043] synonym: "set of straight arterioles of kidney" NARROW [FMA:72006] synonym: "straight arterioles of kidney" NARROW [FMA:72006] synonym: "vasa recta of kidney" EXACT [FMA:72006] synonym: "vasa recta renis" EXACT OMO:0003011 [FMA:72006, FMA:TA] synonym: "vasa rectae" RELATED [Wikipedia:Vasa_recta] xref: EMAPA:30043 xref: FMA:72006 xref: galen:ArteriaeRectae xref: MA:0002595 xref: Wikipedia:Vasa_recta is_a: UBERON:0006544 ! kidney vasculature relationship: RO:0002170 UBERON:0004640 ! connected to renal efferent arteriole property_value: foaf:depiction "https://upload.wikimedia.org/wikipedia/commons/2/21/Kidney_nephron.png" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0004727 name: cochlear nerve def: "A nerve in the head that carries signals from the cochlea of the inner ear to the brain. It is part of the vestibulocochlear nerve, the 8th cranial nerve which is found in higher vertebrates; the other portion of the 8th cranial nerve is the vestibular nerve which carries spatial orientation information from the semicircular canals. The cochlear nerve is a sensory nerve, one which conducts to the brain information about the environment, in this case acoustic energy impinging on the tympanic membrane. The cochlear nerve arises from within the cochlea and extends to the brainstem, where its fibers make contact with the cochlear nucleus, the next stage of neural processing in the auditory system[WP]." [Wikipedia:Cochlear_nerve] subset: pheno_slim subset: uberon_slim synonym: "auditory nerve" EXACT [FMA:53431] synonym: "cochlear component" BROAD [] synonym: "cochlear root of acoustic nerve" EXACT [FMA:53431] synonym: "cochlear root of eighth cranial nerve" EXACT [FMA:53431] synonym: "nervus vestibulocochlearis" RELATED [BTO:0003490] synonym: "vestibulocochlear nerve cochlear component" RELATED [EMAPA:17802] synonym: "vestibulocochlear VIII nerve cochlear component" EXACT [MA:0001110] xref: BAMS:cVIIIn xref: BM:VIIIN xref: BTO:0003490 xref: EHDAA2:0002195 xref: EMAPA:17802 xref: FMA:53431 xref: GAID:723 xref: MA:0001110 xref: MBA:948 xref: MESH:D003056 xref: NCIT:C12697 xref: neuronames:1406 xref: SCTID:280286001 xref: UMLS:C0009201 {source="ncithesaurus:Cochlear_Nerve"} xref: VHOG:0001182 xref: Wikipedia:Cochlear_nerve is_a: UBERON:0011779 ! nerve of head region intersection_of: UBERON:0001021 ! nerve intersection_of: extends_fibers_into UBERON:0001720 ! cochlear nucleus intersection_of: RO:0002134 UBERON:0001844 ! innervates cochlea intersection_of: RO:0002380 UBERON:0001648 ! branching part of vestibulocochlear nerve relationship: extends_fibers_into UBERON:0001720 ! cochlear nucleus relationship: RO:0002134 UBERON:0001844 ! innervates cochlea relationship: RO:0002380 UBERON:0001648 ! branching part of vestibulocochlear nerve property_value: skos:prefLabel "cochlear nerve" xsd:string [Term] id: UBERON:0004731 name: neuromere def: "A transverse unitary subdivision of the neural tube that shares a common dorsoventral structure (floor, basal, alar, and roof plates), but each having differential molecular identities and fates; they comprise the secondary prosencephalon, diencephalon (prosomeres), the midbrain (mesomeres), and the hindbrain (rhombomeres)." [DOI:10.1016/j.tins.2013.06.004, https://github.com/obophenotype/uberon/issues/318] subset: pheno_slim synonym: "neural metamere" RELATED [] synonym: "neural segment" RELATED [] synonym: "neural tube metameric segment" EXACT [http://orcid.org/0000-0002-6601-2165] synonym: "neural tube segment" EXACT [] synonym: "neuromere" EXACT [] synonym: "neuromeres" EXACT OMO:0003004 [TAO:0001328] xref: NLX:147842 xref: TAO:0001328 xref: Wikipedia:Neuromere xref: ZFA:0001328 is_a: UBERON:0004732 ! segmental subdivision of nervous system intersection_of: UBERON:0004732 ! segmental subdivision of nervous system intersection_of: BFO:0000050 UBERON:0001049 ! part of neural tube relationship: BFO:0000050 UBERON:0001049 ! part of neural tube property_value: IAO:0000116 "We take the definition of neuromere from Puelles et al, although the existence of mesomeres and prosomeres may not be widely accepted" xsd:string property_value: skos:prefLabel "neuromere" xsd:string property_value: terms:contributor https://orcid.org/0000-0001-9114-8737 creation_date: 2009-06-18T09:00:04Z [Term] id: UBERON:0004732 name: segmental subdivision of nervous system def: "Any segmental subdivision of a nervous system. Includes metameric developmental segments, such as vertebrates neuromeres." [FBbt:00005140, http://orcid.org/0000-0002-6601-2165] subset: non_informative synonym: "neuromere" RELATED [FBbt:00005140] is_a: UBERON:0000063 ! organ subunit intersection_of: UBERON:0000063 ! organ subunit intersection_of: BFO:0000050 UBERON:0001016 ! part of nervous system relationship: BFO:0000050 UBERON:0001016 ! part of nervous system property_value: IAO:0000116 "revisit this after CARO is revised and/or we have defined metameric segment; note that with the additional of an A/P axis constraint this corresponds to what Richter at al call a neuromere (PMID:21062451)" xsd:string property_value: skos:prefLabel "segmental subdivision of nervous system" xsd:string [Term] id: UBERON:0004733 name: segmental subdivision of hindbrain def: "An organ subunit that is part of a hindbrain [Automatically generated definition]." [OBOL:automatic] subset: non_informative synonym: "hindbrain segment" EXACT [FMA:61998] synonym: "segment of hindbrain" EXACT [FMA:61998] xref: FMA:61998 is_a: UBERON:0004732 ! segmental subdivision of nervous system intersection_of: UBERON:0000063 ! organ subunit intersection_of: BFO:0000050 UBERON:0002028 ! part of hindbrain relationship: BFO:0000050 UBERON:0002028 ! part of hindbrain property_value: skos:prefLabel "segmental subdivision of hindbrain" xsd:string [Term] id: UBERON:0004734 name: gastrula def: "Organism at the gastrula stage." [Wikipedia:Gastrula, Wikipedia:Trilaminar_blastocyst] subset: pheno_slim synonym: "blastocystis trilaminaris" RELATED [https://orcid.org/0000-0002-6601-2165] synonym: "gastrula embryo" EXACT [BILA:0000060] synonym: "tri-laminar disc" RELATED [https://orcid.org/0000-0002-6601-2165] synonym: "tri-laminar disk" RELATED [https://orcid.org/0000-0002-6601-2165] synonym: "trilaminar blastocyst" RELATED [https://orcid.org/0000-0002-6601-2165] synonym: "trilaminar blastoderm" RELATED [https://orcid.org/0000-0002-6601-2165] synonym: "trilaminar disc" RELATED [https://orcid.org/0000-0002-6601-2165] synonym: "trilaminar disk" RELATED [https://orcid.org/0000-0002-6601-2165] synonym: "trilaminar germ" RELATED [https://orcid.org/0000-0002-6601-2165] xref: BILA:0000060 xref: BTO:0001403 xref: FBbt:00005317 {sssom:mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"} xref: FMA:293108 xref: GAID:1302 xref: MESH:D005775 xref: MIAA:0000179 xref: NCIT:C34057 xref: NCIT:C34058 xref: UMLS:C0017199 {source="ncithesaurus:Gastrula"} xref: UMLS:C1284022 {source="ncithesaurus:Trilaminar_Embryonic_Disc"} xref: Wikipedia:Gastrula xref: Wikipedia:Trilaminar_blastocyst is_a: BFO:0000002 is_a: UBERON:0000922 ! embryo intersection_of: UBERON:0000468 ! multicellular organism intersection_of: RO:0002491 UBERON:0000109 ! existence starts and ends during gastrula stage relationship: RO:0002202 UBERON:0000307 ! develops from blastula relationship: RO:0002491 UBERON:0000109 ! existence starts and ends during gastrula stage property_value: skos:prefLabel "gastrula" xsd:string [Term] id: UBERON:0004736 name: metanephric glomerulus def: "Glomerulus of the mature vertebrate kidney, or metanephros." [GO:0072224] synonym: "glomerulus of metanephros" EXACT [] xref: VHOG:0001242 is_a: UBERON:0000074 ! renal glomerulus intersection_of: UBERON:0000074 ! renal glomerulus intersection_of: BFO:0000050 UBERON:0000081 ! part of metanephros relationship: BFO:0000050 UBERON:0000081 ! part of metanephros [Term] id: UBERON:0004737 name: metanephric collecting duct def: "A collecting duct of renal tubule that is part of a metanephros [Automatically generated definition]." [OBOL:automatic] synonym: "collecting duct of metanephros" EXACT [] synonym: "metanephric collecting tubule" RELATED [VHOG:0000983] xref: VHOG:0000983 is_a: UBERON:0001232 ! collecting duct of renal tubule is_a: UBERON:0004120 ! mesoderm-derived structure intersection_of: UBERON:0001232 ! collecting duct of renal tubule intersection_of: BFO:0000050 UBERON:0000081 ! part of metanephros relationship: BFO:0000050 UBERON:0005110 {is_inferred="true", source="https://github.com/obophenotype/uberon/wiki/Inferring-part-of-relationships"} ! part of metanephric nephron relationship: RO:0002202 UBERON:0003220 {source="Wikipedia-abduced"} ! develops from metanephric mesenchyme relationship: RO:0002202 UBERON:0014706 ! develops from primitive renal collecting duct system [Term] id: UBERON:0004738 name: metanephric juxtaglomerular apparatus def: "Juxtaglomerular apparatus of the mature vertebrate kidney, or metanephros." [GO:0072206] synonym: "juxtaglomerular apparatus of metanephros" EXACT [] is_a: UBERON:0002303 ! juxtaglomerular apparatus intersection_of: UBERON:0002303 ! juxtaglomerular apparatus intersection_of: BFO:0000050 UBERON:0000081 ! part of metanephros relationship: BFO:0000050 UBERON:0010533 {is_inferred="true", source="https://github.com/obophenotype/uberon/wiki/Inferring-part-of-relationships"} ! part of metanephros cortex [Term] id: UBERON:0004739 name: pronephric glomerulus def: "The glomus forms from the splanchnic intermediate mesoderm and is the vascularized filtration unit, filtering the blood before it enters the tubules. The glomus is external to the nephron and extends over more than one body segment." [DOI:10.1371/journal.pone.0099864, GO:0072013, GOC:mtg_kidney_jan10, PMID:10572058, PMID:15647339, PMID:9268568, XAO:0000318] synonym: "corpuscle" RELATED [XAO:0000318] synonym: "glomera" RELATED OMO:0003004 [XAO:0000318] synonym: "glomerulus of pronephros" EXACT [] synonym: "glomus" NARROW [XAO:0000318] synonym: "pronephric glomera" RELATED [VHOG:0001237] synonym: "pronephric glomeruli" RELATED OMO:0003004 [VHOG:0001237] synonym: "pronephric glomus" RELATED [VHOG:0001237] xref: AAO:0011049 xref: SCTID:360548001 xref: TAO:0001557 xref: VHOG:0001237 xref: XAO:0000318 xref: ZFA:0001557 is_a: UBERON:0000074 ! renal glomerulus intersection_of: UBERON:0000074 ! renal glomerulus intersection_of: BFO:0000050 UBERON:0002120 ! part of pronephros relationship: BFO:0000050 UBERON:0002120 ! part of pronephros relationship: RO:0002202 UBERON:0007128 {source="XAO"} ! develops from glomeral mesenchyme [Term] id: UBERON:0004742 name: dentary def: "The dentary is a dermal bone that forms the antero-lateral part of the lower jaw in fishes and amphibians, extending to the whole lower jaw in mammals[VHOG,modified]." [VHOG:0001022] subset: efo_slim synonym: "dentale" RELATED [AAO:0000124] synonym: "dentaries" EXACT OMO:0003004 [TAO:0000191] synonym: "dentary bone" EXACT [ZFA:0000191] synonym: "os dentale" RELATED [AAO:0000124] synonym: "sur-angulaire" RELATED [AAO:0000124] xref: AAO:0000124 xref: EFO:0003508 xref: http://palaeos.com/vertebrates/bones/dermal/images/Dentary1.gif xref: TAO:0000191 xref: VHOG:0001022 xref: ZFA:0000191 is_a: UBERON:0004768 ! bone of lower jaw is_a: UBERON:0008907 {source="ZFA"} ! dermal bone is_a: UBERON:0015212 ! lateral structure relationship: BFO:0000050 UBERON:0003113 ! part of dermatocranium relationship: BSPO:0000126 UBERON:0003278 ! skeleton of lower jaw relationship: RO:0002202 UBERON:0010336 {source="EHDAA2"} ! develops from mandibular process mesenchyme from neural crest relationship: RO:0002254 UBERON:0003324 {source="EHDAA2-modified"} ! has developmental contribution from mesenchyme of lower jaw property_value: skos:prefLabel "dentary" xsd:string [Term] id: UBERON:0004753 name: scapulocoracoid def: "Skeletal element that consists of the scapula and the coracoid[VSAO, modified]." [https://github.com/obophenotype/uberon/issues/125, https://github.com/obophenotype/uberon/issues/66, VSAO:0005002, Wikipedia:Scapulocoracoid] synonym: "coraco-scapular cartilage" NARROW [ZFA:0001455] synonym: "scapulo-coracoid cartilage" NARROW [TAO:0001455] synonym: "scapulocoracoid cartilage" NARROW [TAO:0001455] synonym: "scapulocoracoideum" EXACT [VSAO:0005002] xref: AAO:0000781 xref: TAO:0001455 xref: VSAO:0005002 xref: Wikipedia:Scapulocoracoid xref: ZFA:0001455 is_a: UBERON:0004765 ! skeletal element relationship: BFO:0000050 UBERON:0007831 {source="VSAO"} ! part of pectoral girdle skeleton property_value: IAO:0000116 "todo - decide whether to create separate classes for cartilage & ossified. Wikipedia considers this absent in Therians, but if considered as a grouping of scapula and coracoid then it would be present" xsd:string property_value: terms:contributor https://orcid.org/0000-0001-7972-3866 property_value: terms:contributor https://orcid.org/0000-0001-9114-8737 property_value: terms:contributor https://orcid.org/0000-0002-6601-2165 [Term] id: UBERON:0004755 name: skeletal tissue def: "A specialized form of connective tissue in which the extracellular matrix is firm, providing the tissue with resilience, and/or mineralized and that functions in mechanical and structural support.[VSAO]." [GO_REF:0000034, http://dx.plos.org/10.1371/journal.pone.0051070, https://github.com/obophenotype/uberon/issues/134, PSPUB:0000170, VSAO:0000015] comment: Four classes of mineralized tissues are found in vertebrates: bone, cartilage, dentine, and enamel. We think of cartilage and bone as skeletal tissues and of enamel and dentine as dental tissues, but enamel and dentine arose evolutionarily together with bone as skeletal tissues in the dermal skeleton (exoskeleton) of early vertebrates. Scales and teeth of sharks are examples of dermal skeletal elements that are still composed of the three ancient components-enamel, dentine, and bone. Cartilage, on the other hand, provided the basis for the second vertebrate skeletal system, the endoskeleton (Smith and Hall, 1990; Hall, 1998a,b). some invertebrate skeletal tissues have surprisingly bone-like features. Examples include chondrocytes interconnected by cell processes in cephalopod cartilages (Cole and Hall, 2004a,b), and the calcium phosphate layer in the shells of brachiopods (Rodland et al., 2003). However, neither bone nor mineralized cartilage have been found in invertebrates. Editors notes: TODO - develops_from xref: EMAPA:37744 {source="MA:th"} xref: MA:0003047 xref: SCTID:309311006 xref: VSAO:0000015 xref: XAO:0004038 xref: ZFA:0005619 is_a: BFO:0000002 is_a: UBERON:0002384 {source="VSAO"} ! connective tissue relationship: BFO:0000050 UBERON:0004765 ! part of skeletal element relationship: RO:0002202 CL:0007001 ! develops from skeletogenic cell property_value: skos:prefLabel "skeletal tissue" xsd:string [Term] id: UBERON:0004756 name: dermal skeletal element def: "Dermis-derived entity that is made of skeletal tissue." [http://orcid.org/0000-0002-6601-2165, https://github.com/obophenotype/uberon/issues/206] synonym: "dermal element" EXACT [VSAO:curator] is_a: BFO:0000002 is_a: UBERON:0004765 ! skeletal element intersection_of: UBERON:0004765 ! skeletal element intersection_of: BFO:0000051 UBERON:0004755 ! has part skeletal tissue intersection_of: RO:0002202 UBERON:0002067 ! develops from dermis relationship: BFO:0000051 UBERON:0004755 ! has part skeletal tissue relationship: RO:0002202 UBERON:0002067 ! develops from dermis property_value: skos:prefLabel "dermal skeletal element" xsd:string [Term] id: UBERON:0004757 name: rectal salt gland def: "An evagination of the terminal portion of the intestine that is capable of secreting high concentrations of excess sodium chloride." [http://www.briancoad.com/dictionary/complete%20dictionary.htm, UBERON:cjm] subset: organ_slim synonym: "digitiform gland" BROAD [http://www.briancoad.com/dictionary/complete%20dictionary.htm] synonym: "glandula rectalis" BROAD OMO:0003011 [http://www.briancoad.com/dictionary/complete%20dictionary.htm] synonym: "rectal gland" BROAD [] xref: BTO:0001157 xref: SCTID:80455007 is_a: UBERON:0003408 ! gland of digestive tract is_a: UBERON:0004758 ! salt gland intersection_of: UBERON:0002530 ! gland intersection_of: BFO:0000050 UBERON:0001052 ! part of rectum intersection_of: RO:0002215 GO:0055078 ! capable of sodium ion homeostasis relationship: BFO:0000050 UBERON:0001052 ! part of rectum relationship: RO:0002162 NCBITaxon:7776 ! in taxon Gnathostomata property_value: RO:0002161 NCBITaxon:32523 property_value: RO:0002175 NCBITaxon:118072 property_value: RO:0002175 NCBITaxon:119203 [Term] id: UBERON:0004758 name: salt gland def: "An organ for excreting excess salts. It is found in elasmobranchs, seabirds, and some reptiles.[WP]." [Wikipedia:Salt_gland] subset: functional_classification subset: organ_slim xref: BTO:0001204 xref: GAID:1235 xref: MESH:D012491 xref: Wikipedia:Salt_gland is_a: UBERON:0002530 ! gland intersection_of: UBERON:0002530 ! gland intersection_of: RO:0002215 GO:0055078 ! capable of sodium ion homeostasis relationship: RO:0002162 NCBITaxon:7742 ! in taxon Vertebrata relationship: RO:0002215 GO:0055078 ! capable of sodium ion homeostasis property_value: RO:0002161 NCBITaxon:40674 [Term] id: UBERON:0004759 name: cranial salt gland def: "A salt gland located in the cranium or head region." [OBOL:automatic] subset: organ_slim is_a: UBERON:0004758 ! salt gland intersection_of: UBERON:0004758 ! salt gland intersection_of: BFO:0000050 UBERON:0000033 ! part of head relationship: BFO:0000050 UBERON:0000033 ! part of head [Term] id: UBERON:0004760 name: gland of anal canal def: "A gland that is part of an anal canal [Automatically generated definition]." [OBOL:automatic, Wikipedia:Anal_gland] subset: human_reference_atlas subset: organ_slim synonym: "anal gland" RELATED [] synonym: "anal sac" RELATED SENSU [Wikipedia:Anal_gland] synonym: "gland of anal sac" RELATED [] synonym: "gland of anus" RELATED [] synonym: "rectal gland" RELATED [] xref: EMAPA:27221 xref: EMAPA:27233 xref: EMAPA:27543 xref: FMA:15720 xref: FMA:15724 xref: NCIT:C32068 xref: SCTID:245448005 xref: UMLS:C0162322 {source="ncithesaurus:Anal_Gland"} xref: Wikipedia:Anal_gland is_a: UBERON:0003408 ! gland of digestive tract intersection_of: UBERON:0002530 ! gland intersection_of: BFO:0000050 UBERON:0000159 ! part of anal canal relationship: BFO:0000050 UBERON:0000159 ! part of anal canal property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "gland of anal canal" xsd:string [Term] id: UBERON:0004761 name: cartilaginous neurocranium def: "The primitive cartilagionous skeletal structure of the fetal skull that grows to envelop the rapidly growing embyonic brain. In humans, the chondrocranium begins forming at 28 days from mesenchymal condensations and is fully formed between week 7 and 9 of fetal development. While the majority of the chondrocranium is succeeded by the bony skull in most higher vertebrates, some components do persist into adulthood.[1] In Cartilagious fishes and Agnathans, the chondrocranium persist throughout life.[2] Embryologically, the chondrocranium represent the basal cranial structure, and lay the base for the formation of the endocranium in higher vertebrates[WP]." [Wikipedia:Chondrocranium] synonym: "cartilaginous chondocranium" EXACT [] synonym: "cartilaginous skull" RELATED [] synonym: "cartiligionous skeletal structure of skull" EXACT [] synonym: "chondocranium" RELATED [Wikipedia:Chondrocranium] synonym: "embryonic chondocranium" RELATED [] synonym: "neurocranium" RELATED SENSU [] xref: AAO:0000094 xref: EHDAA:6031 xref: FMA:76621 xref: NCIT:C34121 xref: SCTID:155540009 xref: UMLS:C1516496 {source="ncithesaurus:Chondrocranium"} xref: Wikipedia:Chondrocranium xref: XAO:0003059 is_a: BFO:0000002 is_a: UBERON:0000075 {source="FMA"} ! subdivision of skeletal system relationship: BFO:0000051 UBERON:0002418 ! has part cartilage tissue relationship: RO:0002162 NCBITaxon:7742 ! in taxon Vertebrata relationship: RO:0002202 UBERON:0009617 {source="PMC1571569"} ! develops from head paraxial mesoderm property_value: skos:prefLabel "cartilaginous neurocranium" xsd:string [Term] id: UBERON:0004763 name: endochondral bone tissue def: "Replacement bone tissue that forms within cartilage[VSAO, modified]." [GO:0001958, VSAO:0000145, Wikipedia:Endochondral_ossification] subset: uberon_slim subset: vertebrate_core xref: EMAPA:35304 xref: MA:0002836 xref: Wikipedia:Endochondral_ossification is_a: UBERON:0002481 ! bone tissue intersection_of: UBERON:0002481 ! bone tissue intersection_of: RO:0002353 GO:0001958 ! output of endochondral ossification disjoint_from: UBERON:0004764 ! intramembranous bone tissue relationship: BFO:0000050 UBERON:0002513 ! part of endochondral bone relationship: RO:0002285 UBERON:0002418 ! developmentally replaces cartilage tissue relationship: RO:0002353 GO:0001958 ! output of endochondral ossification [Term] id: UBERON:0004764 name: intramembranous bone tissue def: "Bone tissue that forms directly within mesenchyme, and does not replace other tissues[TAO]. Intramembranous ossification is the formation of bone in which osteoblasts secrete a collagen-proteoglycan matrix that binds calcium salts and becomes calcified[GO]. Intramembranous ossification is the way flat bones and the shell of a turtle are formed[GO]. Unlike endochondral ossification, cartilage is not present during intramembranous ossification[WP]." [GO:0001957, Wikipedia:Intramembranous_ossification] xref: MA:0002837 xref: Wikipedia:Intramembranous_ossification is_a: UBERON:0002481 ! bone tissue intersection_of: UBERON:0002481 ! bone tissue intersection_of: RO:0002353 GO:0001957 ! output of intramembranous ossification relationship: BFO:0000050 UBERON:0002514 ! part of intramembranous bone relationship: RO:0002202 UBERON:0003104 ! develops from mesenchyme relationship: RO:0002353 GO:0001957 ! output of intramembranous ossification property_value: skos:prefLabel "intramembranous bone tissue" xsd:string [Term] id: UBERON:0004765 name: skeletal element def: "Organ consisting of skeletal tissue. Encompasses whole bones, fused bones, cartilaginious elements, teeth, dermal denticles." [https://orcid.org/0000-0002-6601-2165] subset: organ_slim subset: uberon_slim xref: AAO:0011129 xref: galen:SkeletalStructure xref: TAO:0001890 xref: VSAO:0000128 xref: XAO:0004012 xref: ZFA:0005494 is_a: UBERON:0000062 ! organ relationship: BFO:0000050 UBERON:0001434 {source="VSAO"} ! part of skeletal system property_value: skos:prefLabel "skeletal element" xsd:string [Term] id: UBERON:0004766 name: cranial bone def: "A bone that is part of a cranium." [UBERON:automatic] subset: human_reference_atlas synonym: "cranium bone" EXACT [UBERON:automatic] xref: SCTID:181792001 is_a: UBERON:0001474 ! bone element intersection_of: UBERON:0001474 ! bone element intersection_of: BFO:0000050 UBERON:0003128 ! part of cranium relationship: BFO:0000050 UBERON:0003128 ! part of cranium property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "cranial bone" xsd:string [Term] id: UBERON:0004767 name: vomerine tooth def: "A tooth that is on the vomer." [http://www.encyclo.co.uk/define/Vomerine%20teeth] xref: TAO:0001631 is_a: UBERON:0012070 ! palatal tooth intersection_of: UBERON:0001091 ! calcareous tooth intersection_of: RO:0002371 UBERON:0002396 ! attached to vomer relationship: BFO:0000050 UBERON:0017615 ! part of vomerine dentition relationship: RO:0002371 UBERON:0002396 ! attached to vomer [Term] id: UBERON:0004768 name: bone of lower jaw def: "Any bone that is part of the lower jaw skeleton. This includes (when present): the dentary/mandible, the articular, the splenial, the suprangular." [https://orcid.org/0000-0002-6601-2165] subset: grouping_class synonym: "lower jaw bone" EXACT [] is_a: UBERON:0010313 ! neural crest-derived structure is_a: UBERON:0012360 ! bone of jaw intersection_of: UBERON:0001474 ! bone element intersection_of: BFO:0000050 UBERON:0001710 ! part of lower jaw region relationship: BFO:0000050 UBERON:0003278 ! part of skeleton of lower jaw property_value: IAO:0000116 "Do not manually classify under here - bones are automatically classified" xsd:string property_value: skos:prefLabel "bone of lower jaw" xsd:string [Term] id: UBERON:0004769 name: diaphysis def: "Subdivision of long bone which forms the part of the bone between the two epiphyses, excluding the metaphyses[FMA,modified]." [FMA:24013, Wikipedia:Diaphysis] subset: pheno_slim subset: uberon_slim synonym: "body of long bone" EXACT [] synonym: "long bone diaphysis" EXACT [] synonym: "shaft of long bone" EXACT [] xref: EMAPA:35504 xref: FMA:24013 xref: GAID:189 xref: MESH:D018483 xref: SCTID:361729006 xref: Wikipedia:Diaphysis is_a: UBERON:0005055 ! zone of long bone property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/9/94/Illu_long_bone.jpg" xsd:anyURI [Term] id: UBERON:0004770 name: articular system def: "Anatomical system that consists of all the joints of the body." [VSAO:0000181] synonym: "joint system" EXACT [FMA:23878] synonym: "set of all joints" RELATED [] synonym: "set of all joints of body" EXACT [FMA:23878] synonym: "set of joints of body" RELATED [FMA:23878] xref: EMAPA:35150 xref: FMA:23878 xref: MA:0003007 xref: SCTID:361827000 xref: VSAO:0000181 is_a: BFO:0000004 is_a: UBERON:0034925 ! anatomical collection intersection_of: UBERON:0034925 ! anatomical collection intersection_of: RO:0002351 UBERON:0000982 ! has member skeletal joint relationship: BFO:0000050 UBERON:0001434 {source="FMA"} ! part of skeletal system relationship: RO:0002328 GO:0040011 ! functionally related to locomotion relationship: RO:0002351 UBERON:0000982 ! has member skeletal joint relationship: RO:0002492 UBERON:0000066 ! existence ends during fully formed stage property_value: skos:prefLabel "articular system" xsd:string [Term] id: UBERON:0004771 name: posterior nasal aperture def: "Opening/conduit between the nasal cavity and the nasopharynx[AAO] The choanae are separated by the vomer[WP]." [AAO:0000093, Wikipedia:Posterior_nasal_apertures] subset: pheno_slim synonym: "choana" BROAD [Wikipedia:Choane, XAO:0000277] synonym: "choanae" RELATED OMO:0003004 [VHOG:0000545] synonym: "internal naris" BROAD [MA:0001323] synonym: "nasopharyngeal naris" RELATED [] synonym: "posterior choana" RELATED [HP:0004496] synonym: "posterior naris" RELATED [VHOG:0000545] synonym: "posterior nasal apperture" EXACT [XAO:0000277] xref: AAO:0000093 xref: EHDAA2:0000242 xref: EHDAA:7842 xref: EMAPA:17849 xref: FMA:53143 xref: MA:0001323 xref: SCTID:244507001 xref: VHOG:0000545 xref: Wikipedia:Posterior_nasal_apertures xref: XAO:0000277 is_a: UBERON:0010425 ! internal naris intersection_of: UBERON:0010425 ! internal naris intersection_of: RO:0002176 UBERON:0001707 ! connects nasal cavity intersection_of: RO:0002176 UBERON:0001728 ! connects nasopharynx relationship: BFO:0000050 UBERON:0003128 ! part of cranium relationship: RO:0002176 UBERON:0001728 ! connects nasopharynx property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/8/87/Gray855.png" xsd:anyURI [Term] id: UBERON:0004775 name: outer renal medulla vasa recta def: "A vasa recta that is part of a outer medulla of kidney [Automatically generated definition]." [OBOL:automatic] subset: pheno_slim synonym: "kidney outer medulla vasa recta" EXACT [MP:0011330] synonym: "kidney outer renal medulla vasa recta" EXACT [MP:0011330] synonym: "outer medulla of kidney vasa recta" EXACT [OBOL:automatic] synonym: "outer zone of medulla of kidney vasa recta" EXACT [OBOL:automatic] synonym: "outer zone of renal medulla vasa recta" EXACT [OBOL:automatic] synonym: "vasa recta of outer medulla of kidney" EXACT [OBOL:automatic] synonym: "vasa recta of outer renal medulla" EXACT [OBOL:automatic] synonym: "vasa recta of outer zone of medulla of kidney" EXACT [OBOL:automatic] synonym: "vasa recta of outer zone of renal medulla" EXACT [OBOL:automatic] xref: EMAPA:36560 xref: MA:0002597 is_a: UBERON:0004726 ! vasa recta intersection_of: UBERON:0004726 ! vasa recta intersection_of: BFO:0000050 UBERON:0001293 ! part of outer medulla of kidney relationship: BFO:0000050 UBERON:0001293 ! part of outer medulla of kidney relationship: RO:0002433 UBERON:0001293 ! contributes to morphology of outer medulla of kidney [Term] id: UBERON:0004776 name: inner renal medulla vasa recta def: "A vasa recta that is part of a inner medulla of kidney [Automatically generated definition]." [OBOL:automatic] subset: pheno_slim synonym: "inner medulla of kidney vasa recta" EXACT [OBOL:automatic] synonym: "inner zone of medulla of kidney vasa recta" EXACT [OBOL:automatic] synonym: "inner zone of renal medulla vasa recta" EXACT [OBOL:automatic] synonym: "set of inner region of renal pyramids vasa recta" EXACT [OBOL:automatic] synonym: "vasa recta of inner medulla of kidney" EXACT [OBOL:automatic] synonym: "vasa recta of inner renal medulla" EXACT [OBOL:automatic] synonym: "vasa recta of inner zone of medulla of kidney" EXACT [OBOL:automatic] synonym: "vasa recta of inner zone of renal medulla" EXACT [OBOL:automatic] synonym: "vasa recta of set of inner region of renal pyramids" EXACT [OBOL:automatic] xref: EMAPA:36559 xref: MA:0002596 is_a: UBERON:0004726 ! vasa recta intersection_of: UBERON:0004726 ! vasa recta intersection_of: BFO:0000050 UBERON:0001294 ! part of inner medulla of kidney relationship: BFO:0000050 UBERON:0001294 ! part of inner medulla of kidney relationship: RO:0002433 UBERON:0001294 ! contributes to morphology of inner medulla of kidney [Term] id: UBERON:0004777 name: respiratory system submucosa def: "A submucosa that is part of a respiratory system [Automatically generated definition]." [OBOL:automatic] synonym: "apparatus respiratorius submucosa" EXACT [OBOL:automatic] synonym: "submucosa of apparatus respiratorius" EXACT [OBOL:automatic] synonym: "submucosa of respiratory system" EXACT [OBOL:automatic] xref: EMAPA:37578 {source="MA:th"} xref: MA:0001822 is_a: UBERON:0000009 ! submucosa intersection_of: UBERON:0000009 ! submucosa intersection_of: BFO:0000050 UBERON:0001004 ! part of respiratory system relationship: BFO:0000050 UBERON:0003570 ! part of respiratory system connective tissue property_value: skos:prefLabel "respiratory system submucosa" xsd:string [Term] id: UBERON:0004778 name: larynx submucosa def: "A submucosa that is part of a larynx [Automatically generated definition]." [OBOL:automatic] synonym: "laryngeal submucosa" RELATED [EMAPA:35474] synonym: "submucosa of larynx" EXACT [OBOL:automatic] xref: EMAPA:35474 xref: FMA:321584 xref: MA:0002728 xref: SCTID:361941005 is_a: UBERON:0004777 ! respiratory system submucosa intersection_of: UBERON:0000009 ! submucosa intersection_of: BFO:0000050 UBERON:0001737 ! part of larynx relationship: BFO:0000050 UBERON:0001737 ! part of larynx property_value: skos:prefLabel "larynx submucosa" xsd:string [Term] id: UBERON:0004779 name: respiratory system lamina propria def: "A lamina propria that is part of a respiratory system [Automatically generated definition]." [OBOL:automatic] synonym: "apparatus respiratorius lamina propria" EXACT [OBOL:automatic] synonym: "apparatus respiratorius lamina propria mucosa" EXACT [OBOL:automatic] synonym: "lamina propria mucosa of apparatus respiratorius" EXACT [OBOL:automatic] synonym: "lamina propria mucosa of respiratory system" EXACT [OBOL:automatic] synonym: "lamina propria of apparatus respiratorius" EXACT [OBOL:automatic] synonym: "lamina propria of respiratory system" EXACT [OBOL:automatic] synonym: "respiratory system lamina propria mucosa" EXACT [OBOL:automatic] xref: EMAPA:37576 {source="MA:th"} xref: MA:0001821 is_a: UBERON:0000030 ! lamina propria intersection_of: UBERON:0000030 ! lamina propria intersection_of: BFO:0000050 UBERON:0001004 ! part of respiratory system relationship: BFO:0000050 UBERON:0003570 ! part of respiratory system connective tissue relationship: BFO:0000050 UBERON:0004785 {is_inferred="true", source="https://github.com/obophenotype/uberon/wiki/Inferring-part-of-relationships"} ! part of respiratory system mucosa property_value: skos:prefLabel "respiratory system lamina propria" xsd:string [Term] id: UBERON:0004780 name: gastrointestinal system lamina propria def: "A lamina propria that is part of a gastrointestinal system." [OBOL:automatic] xref: MA:0001899 xref: NCIT:C49299 xref: UMLS:C1708197 {source="ncithesaurus:Gastrointestinal_Tract_Lamina_Propria"} is_a: UBERON:0000030 ! lamina propria intersection_of: UBERON:0000030 ! lamina propria intersection_of: BFO:0000050 UBERON:0005409 ! part of alimentary part of gastrointestinal system relationship: BFO:0000050 UBERON:0004786 {is_inferred="true", source="https://github.com/obophenotype/uberon/wiki/Inferring-part-of-relationships"} ! part of gastrointestinal system mucosa property_value: skos:prefLabel "gastrointestinal system lamina propria" xsd:string [Term] id: UBERON:0004781 name: gallbladder lamina propria def: "A lamina propria that is part of a gallbladder [Automatically generated definition]." [OBOL:automatic] synonym: "biliary lamina propria" RELATED [MA:0001633] synonym: "gall bladder lamina propria" EXACT [OBOL:automatic] synonym: "gall bladder lamina propria mucosa" EXACT [OBOL:automatic] synonym: "gallbladder lamina propria mucosa" EXACT [] synonym: "lamina propria mucosa of gall bladder" EXACT [OBOL:automatic] synonym: "lamina propria mucosa of gallbladder" EXACT [OBOL:automatic] synonym: "lamina propria of gall bladder" EXACT [OBOL:automatic] synonym: "lamina propria of gallbladder" EXACT [OBOL:automatic] xref: EMAPA:35371 xref: FMA:278594 xref: MA:0001633 xref: NCIT:C49228 xref: UMLS:C1708175 {source="ncithesaurus:Gallbladder_Lamina_Propria"} is_a: UBERON:0000030 ! lamina propria intersection_of: UBERON:0000030 ! lamina propria intersection_of: BFO:0000050 UBERON:0002110 ! part of gallbladder relationship: BFO:0000050 UBERON:0005033 {is_inferred="true", source="https://github.com/obophenotype/uberon/wiki/Inferring-part-of-relationships"} ! part of mucosa of gallbladder property_value: skos:prefLabel "gallbladder lamina propria" xsd:string [Term] id: UBERON:0004782 name: gastrointestinal system serosa def: "A serous membrane that is part of a digestive system [Automatically generated definition]." [OBOL:automatic] synonym: "digestive system serosa" EXACT [OBOL:automatic] synonym: "digestive system serous membrane" EXACT [OBOL:automatic] synonym: "gastrointestinal system serous membrane" EXACT [OBOL:automatic] synonym: "serosa of digestive system" EXACT [OBOL:automatic] synonym: "serosa of gastrointestinal system" EXACT [OBOL:automatic] synonym: "serous membrane of digestive system" EXACT [OBOL:automatic] synonym: "serous membrane of gastrointestinal system" EXACT [OBOL:automatic] xref: EMAPA:37592 {source="MA:th"} xref: MA:0001522 is_a: UBERON:0000042 ! serous membrane intersection_of: UBERON:0000042 ! serous membrane intersection_of: BFO:0000050 UBERON:0005409 ! part of alimentary part of gastrointestinal system relationship: BFO:0000050 UBERON:0005409 ! part of alimentary part of gastrointestinal system property_value: skos:prefLabel "gastrointestinal system serosa" xsd:string [Term] id: UBERON:0004783 name: gallbladder serosa def: "A serous membrane that is part of a gallbladder [Automatically generated definition]." [OBOL:automatic] synonym: "biliary serosa" RELATED [MA:0001634] synonym: "gall bladder serosa" EXACT [OBOL:automatic] synonym: "gall bladder serous membrane" EXACT [] synonym: "gallbladder serous membrane" EXACT [OBOL:automatic] synonym: "serosa of gall bladder" EXACT [OBOL:automatic] synonym: "serosa of gallbladder" EXACT [OBOL:automatic] synonym: "serous coat of gallbladder" EXACT [FMA:14659] synonym: "serous membrane of gall bladder" EXACT [OBOL:automatic] synonym: "serous membrane of gallbladder" EXACT [OBOL:automatic] synonym: "tunica serosa (vesica biliaris)" EXACT [FMA:14659] synonym: "tunica serosa vesicae biliaris" EXACT OMO:0003011 [FMA:14659, FMA:TA] xref: EMAPA:35372 xref: FMA:14659 xref: MA:0001634 xref: SCTID:362197006 is_a: UBERON:0000042 ! serous membrane intersection_of: UBERON:0000042 ! serous membrane intersection_of: BFO:0000050 UBERON:0002110 ! part of gallbladder relationship: BFO:0000050 UBERON:0002110 ! part of gallbladder property_value: skos:prefLabel "gallbladder serosa" xsd:string [Term] id: UBERON:0004784 name: heart ventricle wall def: "An anatomical wall that is part of a cardiac ventricle [Automatically generated definition]." [OBOL:automatic] subset: pheno_slim synonym: "anatomical wall of cardiac ventricle" EXACT [OBOL:automatic] synonym: "anatomical wall of heart ventricle" EXACT [OBOL:automatic] synonym: "anatomical wall of lower chamber of heart" EXACT [OBOL:automatic] synonym: "anatomical wall of ventricle of heart" EXACT [OBOL:automatic] synonym: "cardiac ventricle anatomical wall" EXACT [OBOL:automatic] synonym: "cardiac ventricle wall" EXACT [OBOL:automatic] synonym: "heart ventricle anatomical wall" EXACT [OBOL:automatic] synonym: "lower chamber of heart anatomical wall" EXACT [OBOL:automatic] synonym: "lower chamber of heart wall" EXACT [OBOL:automatic] synonym: "ventricle of heart anatomical wall" EXACT [OBOL:automatic] synonym: "ventricle of heart wall" EXACT [OBOL:automatic] synonym: "ventricular wall" EXACT [FMA:13884] synonym: "wall of cardiac ventricle" EXACT [OBOL:automatic] synonym: "wall of heart ventricle" EXACT [OBOL:automatic] synonym: "wall of lower chamber of heart" EXACT [OBOL:automatic] synonym: "wall of ventricle" RELATED [MA:0002791] synonym: "wall of ventricle of heart" EXACT [OBOL:automatic] xref: FMA:13884 xref: MA:0002791 xref: NCIT:C119295 is_a: UBERON:0037144 ! wall of heart intersection_of: UBERON:0000060 ! anatomical wall intersection_of: BFO:0000050 UBERON:0002082 ! part of cardiac ventricle relationship: BFO:0000050 UBERON:0002082 ! part of cardiac ventricle property_value: skos:prefLabel "heart ventricle wall" xsd:string [Term] id: UBERON:0004785 name: respiratory system mucosa def: "The mucous membrane lining the respiratory tract." [MESH:A04.760, MGI:cwg, MP:0002277] subset: pheno_slim synonym: "apparatus respiratorius mucosa" EXACT [OBOL:automatic] synonym: "apparatus respiratorius mucosa of organ" EXACT [OBOL:automatic] synonym: "apparatus respiratorius mucous membrane" EXACT [OBOL:automatic] synonym: "laryngeal mucous membrane" RELATED [EMAPA:18334] synonym: "mucosa of apparatus respiratorius" EXACT [OBOL:automatic] synonym: "mucosa of organ of apparatus respiratorius" EXACT [OBOL:automatic] synonym: "mucosa of organ of respiratory system" EXACT [OBOL:automatic] synonym: "mucosa of respiratory system" EXACT [OBOL:automatic] synonym: "mucous membrane of apparatus respiratorius" EXACT [OBOL:automatic] synonym: "mucous membrane of respiratory system" EXACT [OBOL:automatic] synonym: "respiratory mucosa" RELATED [BTO:0000973] synonym: "respiratory system mucosa of organ" EXACT [OBOL:automatic] synonym: "respiratory system mucous membrane" EXACT [OBOL:automatic] synonym: "respiratory tract mucosa" RELATED [] xref: BTO:0000973 xref: EMAPA:37577 {source="MA:th"} xref: FMA:302092 xref: GAID:304 xref: MA:0001827 xref: MESH:D020545 is_a: UBERON:0000344 ! mucosa intersection_of: UBERON:0000344 ! mucosa intersection_of: BFO:0000050 UBERON:0001004 ! part of respiratory system relationship: BFO:0000050 UBERON:0001004 ! part of respiratory system property_value: IAO:0000116 "TODO - split respiratory tract mucosa from respiratory system mucosa" xsd:string property_value: skos:prefLabel "respiratory system mucosa" xsd:string [Term] id: UBERON:0004786 name: gastrointestinal system mucosa def: "A mucosa that is part of a gastrointestinal system." [OBOL:automatic] comment: The gut mucosa of amphioxus has insulin-secreting cells. http://www.ncbi.nlm.nih.gov/pubmed/16417468 synonym: "digestive tract mucosa" EXACT [https://orcid.org/0000-0002-6601-2165] synonym: "gut mucosa" EXACT [BTO:0000546] synonym: "gut mucuous membrane" EXACT [https://orcid.org/0000-0002-6601-2165] synonym: "mucosa of gut" EXACT [https://orcid.org/0000-0002-6601-2165] xref: BTO:0000546 xref: BTO:0005568 xref: EMAPA:36591 xref: MA:0001521 xref: SCTID:410433007 is_a: UBERON:0000344 ! mucosa intersection_of: UBERON:0000344 ! mucosa intersection_of: BFO:0000050 UBERON:0005409 ! part of alimentary part of gastrointestinal system relationship: BFO:0000050 UBERON:0001555 ! part of digestive tract relationship: BFO:0000050 UBERON:0005409 ! part of alimentary part of gastrointestinal system relationship: BFO:0000051 CL:0000172 {source="PMID:16417468"} ! has part somatostatin secreting cell relationship: BFO:0000051 CL:0000696 {source="PMID:16417468"} ! has part PP cell relationship: BFO:0000051 CL:0002067 {source="PMID:16417468"} ! has part type A enteroendocrine cell relationship: RO:0002220 UBERON:0006909 {source="BTO-modified"} ! adjacent to lumen of digestive tract property_value: skos:prefLabel "gastrointestinal system mucosa" xsd:string [Term] id: UBERON:0004787 name: urethra urothelium def: "An urothelium that is part of a urethra [Automatically generated definition]." [OBOL:automatic] subset: pheno_slim synonym: "urethra uroepithelium" EXACT [OBOL:automatic] synonym: "uroepithelium of urethra" EXACT [OBOL:automatic] synonym: "urothelium of urethra" EXACT [OBOL:automatic] xref: EMAPA:35896 xref: MA:0001687 xref: NCIT:C49310 xref: UMLS:C1710585 {source="ncithesaurus:Urethra_Transitional_Cell_Epithelium"} is_a: UBERON:0000365 ! urothelium is_a: UBERON:0002325 ! epithelium of urethra intersection_of: UBERON:0000365 ! urothelium intersection_of: BFO:0000050 UBERON:0000057 ! part of urethra relationship: RO:0002433 UBERON:0000057 ! contributes to morphology of urethra [Term] id: UBERON:0004788 name: kidney pelvis urothelium def: "The epithelial lining of the luminal space of the kidney pelvis." [MGI:csmith, MP:0011336] subset: pheno_slim synonym: "kidney pelvis transitional epithelium" EXACT [OBOL:automatic] synonym: "kidney pelvis uroepithelium" EXACT [OBOL:automatic] synonym: "pelvic urothelium" RELATED [EMAPA:28077] synonym: "pelvis of ureter uroepithelium" EXACT [OBOL:automatic] synonym: "pelvis of ureter urothelium" EXACT [OBOL:automatic] synonym: "renal pelvis transitional epithelium" EXACT [OBOL:automatic] synonym: "renal pelvis uroepithelium" EXACT [OBOL:automatic] synonym: "renal pelvis urothelium" EXACT [OBOL:automatic] synonym: "transitional epithelium of kidney pelvis" EXACT [OBOL:automatic] synonym: "transitional epithelium of renal pelvis" EXACT [FMA:263264] synonym: "uroepithelium of kidney pelvis" EXACT [OBOL:automatic] synonym: "uroepithelium of pelvis of ureter" EXACT [OBOL:automatic] synonym: "uroepithelium of renal pelvis" EXACT [OBOL:automatic] synonym: "urothelium of kidney pelvis" EXACT [OBOL:automatic] synonym: "urothelium of pelvis of ureter" EXACT [OBOL:automatic] synonym: "urothelium of renal pelvis" EXACT [OBOL:automatic] xref: EMAPA:28077 xref: FMA:263264 xref: MA:0002632 xref: NCIT:C54556 xref: UMLS:C1709899 {source="ncithesaurus:Renal_Pelvis_Urothelium"} is_a: UBERON:0000365 ! urothelium is_a: UBERON:0004819 ! kidney epithelium intersection_of: UBERON:0000365 ! urothelium intersection_of: BFO:0000050 UBERON:0001224 ! part of renal pelvis relationship: BFO:0000050 UBERON:0001224 ! part of renal pelvis relationship: RO:0002433 UBERON:0001224 ! contributes to morphology of renal pelvis [Term] id: UBERON:0004789 name: larynx mucous gland def: "A mucous gland that is part of a larynx [Automatically generated definition]." [OBOL:automatic] synonym: "mucous gland of larynx" EXACT [OBOL:automatic] xref: EMAPA:37631 {source="MA:th"} xref: MA:0001767 is_a: UBERON:0000414 ! mucous gland is_a: UBERON:0036225 ! respiratory system gland intersection_of: UBERON:0000414 ! mucous gland intersection_of: BFO:0000050 UBERON:0001737 ! part of larynx relationship: BFO:0000050 UBERON:0001824 ! part of mucosa of larynx property_value: skos:prefLabel "larynx mucous gland" xsd:string [Term] id: UBERON:0004790 name: skin mucous gland def: "A mucous gland that is part of the skin." [http://orcid.org/0000-0002-6601-2165] subset: organ_slim synonym: "mucous gland of entire skin" EXACT [OBOL:automatic] synonym: "mucous gland of skin of body" EXACT [OBOL:automatic] synonym: "skin mucus gland" EXACT [OBOL:automatic] synonym: "skin of body mucous gland" EXACT [OBOL:automatic] xref: EMAPA:35775 xref: MA:0000148 is_a: UBERON:0000414 ! mucous gland is_a: UBERON:0007771 ! epidermis gland is_a: UBERON:0019319 ! exocrine gland of integumental system intersection_of: UBERON:0000414 ! mucous gland intersection_of: BFO:0000050 UBERON:0002097 ! part of skin of body property_value: IAO:0000116 "See comments for 'skin mucus'" xsd:string property_value: skos:prefLabel "skin mucous gland" xsd:string [Term] id: UBERON:0004791 name: thymus trabecula def: "The thymic connective tissue which extends into the parenchyma." [ISBN:0-397-51047-0, MGI:cwg, MP:0002370] subset: human_reference_atlas subset: pheno_slim synonym: "thymic trabecula" EXACT [OBOL:automatic] synonym: "thymus gland trabecula" EXACT [OBOL:automatic] synonym: "thymus trabeculae" EXACT OMO:0003004 [] synonym: "trabecula of thymus" EXACT [OBOL:automatic] synonym: "trabecula of thymus gland" EXACT [OBOL:automatic] xref: MA:0002674 xref: NCIT:C33773 xref: UMLS:C1515431 {source="ncithesaurus:Thymic_Trabecula"} is_a: UBERON:0000440 ! trabecula intersection_of: UBERON:0000440 ! trabecula intersection_of: BFO:0000050 UBERON:0002370 ! part of thymus relationship: BFO:0000050 UBERON:0002370 {source="MA"} ! part of thymus relationship: RO:0002433 UBERON:0002370 ! contributes to morphology of thymus property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0004792 name: secretion of endocrine pancreas def: "A secretion that is part of a endocrine pancreas [Automatically generated definition]." [OBOL:automatic] synonym: "endocrine pancreas secretion" EXACT [OBOL:automatic] synonym: "pancreatic endocrine secretion" EXACT [ncithesaurus:Pancreatic_Endocrine_Secretion] synonym: "pars endocrina pancreatis secretion" EXACT [OBOL:automatic] synonym: "secretion of pars endocrina pancreatis" EXACT [OBOL:automatic] xref: MA:0002517 xref: NCIT:C33255 xref: UMLS:C1518866 {source="ncithesaurus:Pancreatic_Endocrine_Secretion"} is_a: UBERON:0004795 ! pancreas secretion intersection_of: UBERON:0000456 ! secretion of exocrine gland intersection_of: BFO:0000050 UBERON:0000016 ! part of endocrine pancreas relationship: BFO:0000050 UBERON:0000016 ! part of endocrine pancreas property_value: skos:prefLabel "secretion of endocrine pancreas" xsd:string [Term] id: UBERON:0004793 name: secretion of exocrine pancreas def: "A secretion that is part of a exocrine pancreas [Automatically generated definition]." [OBOL:automatic] synonym: "exocrine pancreas secretion" EXACT [OBOL:automatic] synonym: "pancreatic exocrine secretion" EXACT [ncithesaurus:Pancreatic_Exocrine_Secretion] synonym: "pars exocrina pancreatis secretion" EXACT [OBOL:automatic] synonym: "secretion of pars exocrina pancreatis" EXACT [OBOL:automatic] xref: MA:0002518 xref: NCIT:C33256 xref: UMLS:C1518867 {source="ncithesaurus:Pancreatic_Exocrine_Secretion"} is_a: UBERON:0004795 ! pancreas secretion intersection_of: UBERON:0000456 ! secretion of exocrine gland intersection_of: BFO:0000050 UBERON:0000017 ! part of exocrine pancreas relationship: BFO:0000050 UBERON:0000017 ! part of exocrine pancreas property_value: skos:prefLabel "secretion of exocrine pancreas" xsd:string [Term] id: UBERON:0004794 name: esophagus secretion def: "A secretion that is part of a esophagus [Automatically generated definition]." [OBOL:automatic] synonym: "esophageal secretion" EXACT [FMA:79662] synonym: "gullet secretion" EXACT [OBOL:automatic] synonym: "oesophagus secretion" EXACT [OBOL:automatic] synonym: "secretion of esophagus" EXACT [OBOL:automatic] synonym: "secretion of gullet" EXACT [OBOL:automatic] synonym: "secretion of oesophagus" EXACT [OBOL:automatic] xref: FMA:79662 xref: MA:0002514 xref: NCIT:C52555 xref: UMLS:C0227179 {source="ncithesaurus:Esophagus_Secretion"} is_a: UBERON:0000456 ! secretion of exocrine gland intersection_of: UBERON:0000456 ! secretion of exocrine gland intersection_of: BFO:0000050 UBERON:0001043 ! part of esophagus relationship: BFO:0000050 UBERON:0001043 ! part of esophagus property_value: skos:prefLabel "esophagus secretion" xsd:string [Term] id: UBERON:0004795 name: pancreas secretion def: "A secretion that is part of a pancreas [Automatically generated definition]." [OBOL:automatic] synonym: "pancreatic secretion" EXACT [OBOL:automatic] synonym: "secretion of pancreas" EXACT [OBOL:automatic] xref: MA:0002516 xref: NCIT:C13270 xref: UMLS:C0030296 {source="ncithesaurus:Pancreatic_Secretion"} is_a: UBERON:0000456 ! secretion of exocrine gland intersection_of: UBERON:0000456 ! secretion of exocrine gland intersection_of: BFO:0000050 UBERON:0001264 ! part of pancreas relationship: BFO:0000050 UBERON:0001264 ! part of pancreas property_value: skos:prefLabel "pancreas secretion" xsd:string [Term] id: UBERON:0004796 name: prostate gland secretion def: "A bodily secretion that is produced by the prostate gland." [http://orcid.org/0000-0002-6601-2165] synonym: "prostate fluid" RELATED [BTO:0001232] synonym: "prostate secretion" EXACT [OBOL:automatic] synonym: "prostatic fluid" EXACT [FMA:66884] synonym: "secretion of prostate" EXACT [OBOL:automatic] synonym: "secretion of prostate gland" EXACT [OBOL:automatic] xref: EMAPA:36545 xref: FMA:66884 xref: MA:0002525 xref: NCIT:C52553 xref: UMLS:C1709733 {source="ncithesaurus:Prostate_Gland_Secretion"} xref: Wikipedia:Prostate#Secretions is_a: UBERON:0006530 {source="FMA"} ! seminal fluid intersection_of: UBERON:0000456 ! secretion of exocrine gland intersection_of: RO:0003001 UBERON:0002367 ! produced by prostate gland relationship: RO:0003001 UBERON:0002367 ! produced by prostate gland [Term] id: UBERON:0004797 name: blood vessel layer def: "Any of the tissue layers that comprise a blood vessel. Examples: tunica media, tunica adventitia." [http://orcid.org/0000-0002-6601-2165] xref: EMAPA:36296 xref: MA:0002854 is_a: UBERON:0004923 ! organ component layer intersection_of: UBERON:0004923 ! organ component layer intersection_of: BFO:0000050 UBERON:0001981 ! part of blood vessel relationship: BFO:0000050 UBERON:0035965 ! part of wall of blood vessel property_value: foaf:depiction "https://upload.wikimedia.org/wikipedia/commons/6/61/Blood_vessels.svg" xsd:anyURI property_value: skos:prefLabel "blood vessel layer" xsd:string [Term] id: UBERON:0004798 name: respiratory system basal lamina def: "A basal lamina that is part of a respiratory system [Automatically generated definition]." [OBOL:automatic] synonym: "apparatus respiratorius basal lamina" EXACT [OBOL:automatic] synonym: "apparatus respiratorius basal lamina of connective tissue" EXACT [OBOL:automatic] synonym: "basal lamina of apparatus respiratorius" EXACT [OBOL:automatic] synonym: "basal lamina of connective tissue of apparatus respiratorius" EXACT [OBOL:automatic] synonym: "basal lamina of connective tissue of respiratory system" EXACT [OBOL:automatic] synonym: "basal lamina of respiratory system" EXACT [OBOL:automatic] synonym: "respiratory system basal lamina of connective tissue" EXACT [OBOL:automatic] xref: EMAPA:37571 {source="MA:th"} xref: MA:0001816 is_a: UBERON:0000482 ! basal lamina of epithelium intersection_of: UBERON:0000482 ! basal lamina of epithelium intersection_of: BFO:0000050 UBERON:0001004 ! part of respiratory system relationship: BFO:0000050 UBERON:0001004 ! part of respiratory system [Term] id: UBERON:0004799 name: trachea basal lamina def: "A basal lamina that is part of a respiratory airway [Automatically generated definition]." [OBOL:automatic] synonym: "basal lamina of connective tissue of respiratory airway" EXACT [OBOL:automatic] xref: EMAPA:37553 {source="MA:th"} xref: MA:0001855 xref: NCIT:C49303 xref: UMLS:C1710454 {source="ncithesaurus:Trachea_Basal_Lamina"} is_a: UBERON:0004798 ! respiratory system basal lamina intersection_of: UBERON:0000482 ! basal lamina of epithelium intersection_of: BFO:0000050 UBERON:0001005 ! part of respiratory airway relationship: BFO:0000050 UBERON:0001005 ! part of respiratory airway [Term] id: UBERON:0004800 name: bronchus basal lamina def: "A basal lamina that is part of a bronchus [Automatically generated definition]." [OBOL:automatic] synonym: "basal lamina of bronchi" EXACT [OBOL:automatic] synonym: "basal lamina of bronchial trunk" EXACT [OBOL:automatic] synonym: "basal lamina of bronchus" EXACT [OBOL:automatic] synonym: "basal lamina of connective tissue of bronchi" EXACT [OBOL:automatic] synonym: "basal lamina of connective tissue of bronchial trunk" EXACT [OBOL:automatic] synonym: "basal lamina of connective tissue of bronchus" EXACT [OBOL:automatic] synonym: "bronchi basal lamina" EXACT [OBOL:automatic] synonym: "bronchi basal lamina of connective tissue" EXACT [OBOL:automatic] synonym: "bronchial trunk basal lamina" EXACT [OBOL:automatic] synonym: "bronchial trunk basal lamina of connective tissue" EXACT [OBOL:automatic] synonym: "bronchus basal lamina of connective tissue" EXACT [OBOL:automatic] xref: EMAPA:37810 {source="MA:th"} xref: MA:0001833 xref: NCIT:C49207 xref: UMLS:C1707050 {source="ncithesaurus:Bronchus_Basal_Lamina"} is_a: UBERON:0004799 ! trachea basal lamina intersection_of: UBERON:0000482 ! basal lamina of epithelium intersection_of: BFO:0000050 UBERON:0002185 ! part of bronchus relationship: BFO:0000050 UBERON:0002185 ! part of bronchus [Term] id: UBERON:0004801 name: cervix epithelium def: "An epithelium that is part of a uterine cervix [Automatically generated definition]." [OBOL:automatic] subset: efo_slim subset: human_reference_atlas subset: pheno_slim synonym: "cervical canal epithelial tissue" EXACT [OBOL:automatic] synonym: "cervical canal epithelium" EXACT [OBOL:automatic] synonym: "cervical epithelium" EXACT [BTO:0000241] synonym: "cervix epithelial tissue" EXACT [OBOL:automatic] synonym: "epithelium of cervix" EXACT [OBOL:automatic] xref: BTO:0000241 xref: CALOHA:TS-0137 xref: EFO:0001913 xref: EMAPA:29929 xref: MA:0001724 xref: NCIT:C49218 xref: UMLS:C1711358 {source="ncithesaurus:Cervix_Epithelium"} is_a: UBERON:0006955 ! uterine epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: BFO:0000050 UBERON:0000002 ! part of uterine cervix relationship: BFO:0000050 UBERON:0000002 ! part of uterine cervix relationship: RO:0002433 UBERON:0000002 ! contributes to morphology of uterine cervix property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0004802 name: respiratory tract epithelium def: "The pseudostratified ciliated epithelium that lines much of the conducting portion of the airway, including part of the nasal cavity and larynx, the trachea, and bronchi." [ISBN:0-683-40008-8, MGI:anna, MP:0010942] subset: pheno_slim synonym: "airway epithelium" RELATED [BTO:0000419] synonym: "epithelial tissue of respiratory tract" EXACT [OBOL:automatic] synonym: "epithelium of respiratory tract" EXACT [OBOL:automatic] synonym: "respiratory epithelium" RELATED [BTO:0000419] synonym: "respiratory tract epithelial tissue" EXACT [OBOL:automatic] xref: BTO:0000419 xref: CALOHA:TS-0023 xref: EMAPA:32827 xref: MA:0001480 xref: SCTID:321764001 is_a: UBERON:0004807 ! respiratory system epithelium is_a: UBERON:0010499 ! pseudostratified ciliated columnar epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: BFO:0000050 UBERON:0000065 ! part of respiratory tract relationship: BFO:0000050 UBERON:0000072 ! part of proximo-distal subdivision of respiratory tract relationship: RO:0002433 UBERON:0001004 ! contributes to morphology of respiratory system property_value: skos:prefLabel "respiratory tract epithelium" xsd:string [Term] id: UBERON:0004803 name: penis epithelium def: "An epithelium that is part of a penis [Automatically generated definition]." [OBOL:automatic] synonym: "epithelial tissue of penis" EXACT [OBOL:automatic] synonym: "epithelium of penis" EXACT [OBOL:automatic] synonym: "penis epithelial tissue" EXACT [OBOL:automatic] xref: EHDAA2:0004039 xref: EMAPA:35674 xref: MA:0001742 is_a: UBERON:0000483 ! epithelium is_a: UBERON:0005156 ! reproductive structure intersection_of: UBERON:0000483 ! epithelium intersection_of: BFO:0000050 UBERON:0000989 ! part of penis relationship: BFO:0000050 UBERON:0000989 ! part of penis [Term] id: UBERON:0004804 name: oviduct epithelium def: "An epithelium that is part of a oviduct [Automatically generated definition]." [OBOL:automatic] subset: human_reference_atlas synonym: "columnar epithelium of the fallopian tube" RELATED [BTO:0002402] synonym: "columnar epithelium of the oviduct" RELATED [BTO:0002402] synonym: "epithelial tissue of oviduct" EXACT [OBOL:automatic] synonym: "epithelium of fallopian tube" EXACT [OBOL:automatic] synonym: "epithelium of oviduct" EXACT [OBOL:automatic] synonym: "epithelium of uterine tube" EXACT [FMA:62016] synonym: "fallopian tube epithelium" RELATED [BTO:0002402] synonym: "oviduct epithelial tissue" EXACT [OBOL:automatic] xref: BTO:0002402 xref: CALOHA:TS-1316 xref: EMAPA:29043 xref: MA:0001718 is_a: UBERON:0000483 ! epithelium is_a: UBERON:0005156 ! reproductive structure intersection_of: UBERON:0000483 ! epithelium intersection_of: BFO:0000050 UBERON:0000993 ! part of oviduct relationship: BFO:0000050 UBERON:0000993 ! part of oviduct property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0004805 name: seminal vesicle epithelium def: "An epithelium that is part of a seminal vesicle [Automatically generated definition]." [OBOL:automatic] synonym: "epithelial tissue of seminal gland" EXACT [OBOL:automatic] synonym: "epithelial tissue of seminal vesicle" EXACT [OBOL:automatic] synonym: "epithelium of seminal gland" EXACT [OBOL:automatic] synonym: "epithelium of seminal vesicle" EXACT [OBOL:automatic] synonym: "seminal gland epithelial tissue" EXACT [OBOL:automatic] synonym: "seminal gland epithelium" EXACT [OBOL:automatic] synonym: "seminal vesicle epithelial tissue" EXACT [OBOL:automatic] xref: CALOHA:TS-2069 xref: EMAPA:29771 xref: MA:0001745 xref: NCIT:C49295 xref: UMLS:C1710049 {source="ncithesaurus:Seminal_Vesicle_Epithelium"} is_a: UBERON:0004910 ! epithelium of male gonad is_a: UBERON:0034969 ! epithelial layer of duct intersection_of: UBERON:0000483 ! epithelium intersection_of: BFO:0000050 UBERON:0000998 ! part of seminal vesicle relationship: BFO:0000050 UBERON:0000998 ! part of seminal vesicle [Term] id: UBERON:0004806 name: vas deferens epithelium def: "An epithelium that is part of a vas deferens [Automatically generated definition]." [OBOL:automatic] synonym: "deferent duct epithelial tissue" EXACT [OBOL:automatic] synonym: "deferent duct epithelium" EXACT [OBOL:automatic] synonym: "ductus deferens epithelial tissue" EXACT [OBOL:automatic] synonym: "ductus deferens epithelium" EXACT [OBOL:automatic] synonym: "epithelial tissue of deferent duct" EXACT [OBOL:automatic] synonym: "epithelial tissue of ductus deferens" EXACT [OBOL:automatic] synonym: "epithelial tissue of sperm duct" EXACT [OBOL:automatic] synonym: "epithelial tissue of vas deferen" EXACT [OBOL:automatic] synonym: "epithelial tissue of vas deferens" EXACT [OBOL:automatic] synonym: "epithelium of deferent duct" EXACT [OBOL:automatic] synonym: "epithelium of ductus deferens" EXACT [OBOL:automatic] synonym: "epithelium of sperm duct" EXACT [OBOL:automatic] synonym: "epithelium of vas deferen" EXACT [OBOL:automatic] synonym: "epithelium of vas deferens" EXACT [OBOL:automatic] synonym: "sperm duct epithelial tissue" EXACT [OBOL:automatic] synonym: "sperm duct epithelium" EXACT [OBOL:automatic] synonym: "vas deferen epithelial tissue" EXACT [OBOL:automatic] synonym: "vas deferen epithelium" EXACT [OBOL:automatic] synonym: "vas deferens epithelial tissue" EXACT [OBOL:automatic] xref: EMAPA:29274 xref: FMA:225317 xref: MA:0001749 xref: NCIT:C49315 xref: UMLS:C1710617 {source="ncithesaurus:Vas_Deferens_Epithelium"} is_a: UBERON:0005156 ! reproductive structure is_a: UBERON:0034969 ! epithelial layer of duct intersection_of: UBERON:0000483 ! epithelium intersection_of: BFO:0000050 UBERON:0001000 ! part of vas deferens relationship: BFO:0000050 UBERON:0001000 ! part of vas deferens [Term] id: UBERON:0004807 name: respiratory system epithelium def: "An epithelium that is part of a respiratory system [Automatically generated definition]." [OBOL:automatic] subset: pheno_slim synonym: "apparatus respiratorius epithelial tissue" EXACT [OBOL:automatic] synonym: "apparatus respiratorius epithelium" EXACT [OBOL:automatic] synonym: "epithelial tissue of apparatus respiratorius" EXACT [OBOL:automatic] synonym: "epithelial tissue of respiratory system" EXACT [OBOL:automatic] synonym: "epithelium of apparatus respiratorius" EXACT [OBOL:automatic] synonym: "epithelium of respiratory system" EXACT [OBOL:automatic] synonym: "respiratory system epithelial tissue" EXACT [OBOL:automatic] xref: CALOHA:TS-0023 xref: EMAPA:32826 xref: MA:0001823 is_a: UBERON:0000483 ! epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: BFO:0000050 UBERON:0001004 ! part of respiratory system relationship: BFO:0000050 UBERON:0001004 ! part of respiratory system property_value: skos:prefLabel "respiratory system epithelium" xsd:string [Term] id: UBERON:0004808 name: gastrointestinal system epithelium def: "An epithelium that is part of a digestive system [Automatically generated definition]." [OBOL:automatic] synonym: "digestive system epithelial tissue" EXACT [OBOL:automatic] synonym: "digestive system epithelium" EXACT [OBOL:automatic] synonym: "epithelial tissue of digestive system" EXACT [OBOL:automatic] synonym: "epithelial tissue of gastrointestinal system" EXACT [OBOL:automatic] synonym: "epithelium of digestive system" EXACT [OBOL:automatic] synonym: "epithelium of gastrointestinal system" EXACT [OBOL:automatic] synonym: "gastrointestinal system epithelial tissue" EXACT [OBOL:automatic] xref: EMAPA:32683 xref: MA:0001520 is_a: UBERON:0000483 ! epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: BFO:0000050 UBERON:0005409 ! part of alimentary part of gastrointestinal system relationship: BFO:0000050 UBERON:0005409 ! part of alimentary part of gastrointestinal system property_value: skos:prefLabel "gastrointestinal system epithelium" xsd:string [Term] id: UBERON:0004809 name: salivary gland epithelium def: "An epithelium that is part of a salivary gland [Automatically generated definition]." [OBOL:automatic] subset: pheno_slim synonym: "epithelial tissue of salivary gland" EXACT [OBOL:automatic] synonym: "epithelium of salivary gland" EXACT [OBOL:automatic] synonym: "salivary gland epithelial tissue" EXACT [OBOL:automatic] xref: BTO:0004421 xref: CALOHA:TS-2067 xref: EMAPA:32816 xref: MA:0001587 is_a: UBERON:0003929 ! digestive tract epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: BFO:0000050 UBERON:0001044 ! part of saliva-secreting gland relationship: BFO:0000050 UBERON:0001044 ! part of saliva-secreting gland [Term] id: UBERON:0004810 name: nephron tubule epithelium def: "The cellular avascular layer of the renal tubule luminar surfaces." [MGI:csmith, MP:0009640] subset: pheno_slim synonym: "kidney tubule epithelium" EXACT [MA:0001681] xref: BTO:0005239 xref: EMAPA:36524 xref: MA:0001681 xref: NCIT:C49276 xref: UMLS:C1709902 {source="ncithesaurus:Renal_Tubule_Epithelium"} is_a: UBERON:0004211 ! nephron epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: BFO:0000050 UBERON:0001231 ! part of nephron tubule intersection_of: RO:0002220 UBERON:0000464 ! adjacent to anatomical space relationship: BFO:0000050 UBERON:0001231 ! part of nephron tubule relationship: RO:0002220 UBERON:0000464 ! adjacent to anatomical space relationship: RO:0002433 UBERON:0001231 ! contributes to morphology of nephron tubule property_value: IAO:0000116 "See https://github.com/obophenotype/uberon/issues/1305" xsd:string [Term] id: UBERON:0004811 name: endometrium epithelium def: "An epithelium that is part of an endometrium [Automatically generated definition]." [OBOL:automatic] subset: pheno_slim synonym: "endometrium epithelial tissue" EXACT [OBOL:automatic] synonym: "epithelial tissue of endometrium" EXACT [OBOL:automatic] synonym: "epithelium of endometrium" EXACT [OBOL:automatic] synonym: "epithelium of tunica mucosa of endometrium" EXACT [OBOL:automatic] synonym: "uterine epithelium" RELATED [PMID:19829370] xref: EMAPA:35307 xref: MA:0002731 xref: SCTID:253526009 is_a: UBERON:0003350 ! epithelium of mucosa is_a: UBERON:0006955 ! uterine epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: BFO:0000050 UBERON:0001295 ! part of endometrium relationship: BFO:0000050 UBERON:0001295 ! part of endometrium [Term] id: UBERON:0004812 name: male prepuce epithelium def: "An epithelium that is part of a prepuce of penis [Automatically generated definition]." [OBOL:automatic] synonym: "epithelial tissue of foreskin" EXACT [OBOL:automatic] synonym: "epithelial tissue of penile prepuce" EXACT [OBOL:automatic] synonym: "epithelial tissue of prepuce" BROAD [OBOL:automatic] synonym: "epithelial tissue of prepuce of penis" EXACT [OBOL:automatic] synonym: "epithelium of foreskin" EXACT [OBOL:automatic] synonym: "epithelium of penile prepuce" EXACT [OBOL:automatic] synonym: "epithelium of prepuce" BROAD [OBOL:automatic] synonym: "epithelium of prepuce of penis" EXACT [OBOL:automatic] synonym: "foreskin epithelial tissue" EXACT [OBOL:automatic] synonym: "foreskin epithelium" EXACT [OBOL:automatic] synonym: "penile prepuce epithelial tissue" EXACT [OBOL:automatic] synonym: "penile prepuce epithelium" EXACT [OBOL:automatic] synonym: "prepuce epithelial tissue" BROAD [OBOL:automatic] synonym: "prepuce epithelium" EXACT [MA:0001753] synonym: "prepuce of penis epithelial tissue" EXACT [OBOL:automatic] synonym: "prepuce of penis epithelium" BROAD [OBOL:automatic] xref: EMAPA:30655 xref: MA:0001753 xref: NCIT:C49270 xref: UMLS:C1709639 {source="ncithesaurus:Prepuce_Epithelium"} is_a: UBERON:0004803 ! penis epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: BFO:0000050 UBERON:0001332 ! part of prepuce of penis relationship: BFO:0000050 UBERON:0001332 ! part of prepuce of penis property_value: IAO:0000116 "NCITA term may be sex-neutral" xsd:string [Term] id: UBERON:0004813 name: seminiferous tubule epithelium def: "The stratified epithelial lining of the seminiferous tubules, consisting of the developing spermatozoa and the supporting Sertoli cells, which are tall, columnar type cells that line the tubule." [MGI:csmith, MP:0011750] subset: pheno_slim synonym: "epithelial tissue of seminiferous tubule" EXACT [OBOL:automatic] synonym: "epithelial tissue of seminiferous tubule of testis" EXACT [OBOL:automatic] synonym: "epithelium of seminiferous tubule" EXACT [OBOL:automatic] synonym: "epithelium of seminiferous tubule of testis" EXACT [OBOL:automatic] synonym: "germinal epithelium (male)" EXACT [Wikipedia:Germinal_epithelium_(male)] synonym: "male germinal epithelium" EXACT [Wikipedia:Germinal_epithelium_(male)] synonym: "seminiferous epithelium" EXACT [BTO:0001811] synonym: "seminiferous tubule epithelial tissue" EXACT [OBOL:automatic] synonym: "testis germinal epithelium" EXACT [VHOG:0000631] synonym: "wall of seminiferous tubule" EXACT [Wikipedia:Germinal_epithelium_(male)] xref: BTO:0001811 xref: CALOHA:TS-0920 xref: EHDAA:8148 xref: EMAPA:35761 xref: FMA:19885 xref: GAID:401 xref: MA:0001748 xref: MESH:D012670 xref: NCIT:C49296 xref: RETIRED_EHDAA2:0002009 xref: UMLS:C0036629 {source="ncithesaurus:Seminiferous_Epithelium"} xref: VHOG:0000631 xref: Wikipedia:Germinal_epithelium_(male) is_a: UBERON:0001136 ! mesothelium is_a: UBERON:0004910 ! epithelium of male gonad is_a: UBERON:0034969 ! epithelial layer of duct intersection_of: UBERON:0000483 ! epithelium intersection_of: BFO:0000050 UBERON:0001343 ! part of seminiferous tubule of testis relationship: BFO:0000050 UBERON:0001343 ! part of seminiferous tubule of testis relationship: BFO:0000051 CL:0000020 ! has part spermatogonium relationship: BFO:0000051 CL:0000216 ! has part Sertoli cell relationship: RO:0002433 UBERON:0001343 ! contributes to morphology of seminiferous tubule of testis [Term] id: UBERON:0004814 name: upper respiratory tract epithelium def: "An epithelium that is part of a upper respiratory tract [Automatically generated definition]." [OBOL:automatic] synonym: "epithelial tissue of upper respiratory tract" EXACT [OBOL:automatic] synonym: "epithelium of upper respiratory tract" EXACT [OBOL:automatic] synonym: "upper respiratory tract epithelial tissue" EXACT [OBOL:automatic] xref: EMAPA:35894 xref: MA:0001912 is_a: UBERON:0004802 ! respiratory tract epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: BFO:0000050 UBERON:0001557 ! part of upper respiratory tract relationship: BFO:0000050 UBERON:0001557 ! part of upper respiratory tract property_value: skos:prefLabel "upper respiratory tract epithelium" xsd:string [Term] id: UBERON:0004815 name: lower respiratory tract epithelium def: "An epithelium that is part of a lower respiratory tract [Automatically generated definition]." [OBOL:automatic] synonym: "epithelial tissue of lower respiratory tract" EXACT [OBOL:automatic] synonym: "epithelium of lower respiratory tract" EXACT [OBOL:automatic] synonym: "lower respiratory tract epithelial tissue" EXACT [OBOL:automatic] xref: EMAPA:37549 {source="MA:th"} xref: MA:0001481 is_a: UBERON:0004802 ! respiratory tract epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: BFO:0000050 UBERON:0001558 ! part of lower respiratory tract relationship: BFO:0000050 UBERON:0001558 ! part of lower respiratory tract property_value: skos:prefLabel "lower respiratory tract epithelium" xsd:string [Term] id: UBERON:0004816 name: larynx epithelium def: "An epithelium that is part of a larynx [Automatically generated definition]." [OBOL:automatic] subset: pheno_slim synonym: "epithelial tissue of larynx" EXACT [OBOL:automatic] synonym: "epithelium of larynx" EXACT [OBOL:automatic] synonym: "laryngeal epithelium" EXACT [OBOL:automatic] synonym: "larynx epithelial tissue" EXACT [OBOL:automatic] xref: EHDAA2:0004065 xref: EMAPA:35472 xref: MA:0001765 xref: NCIT:C49247 xref: UMLS:C0751258 {source="ncithesaurus:Laryngeal_Epithelium"} is_a: UBERON:0004802 ! respiratory tract epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: BFO:0000050 UBERON:0001737 ! part of larynx relationship: BFO:0000050 UBERON:0001737 ! part of larynx relationship: RO:0002433 UBERON:0001737 ! contributes to morphology of larynx property_value: skos:prefLabel "larynx epithelium" xsd:string [Term] id: UBERON:0004817 name: lacrimal gland epithelium def: "An epithelium that is part of a lacrimal gland [Automatically generated definition]." [OBOL:automatic] synonym: "epithelial tissue of lacrimal gland" EXACT [OBOL:automatic] synonym: "epithelium of lacrimal gland" EXACT [OBOL:automatic] synonym: "lacrimal gland epithelial tissue" EXACT [OBOL:automatic] xref: EMAPA:36515 xref: MA:0001297 is_a: UBERON:0015808 ! eye epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: BFO:0000050 UBERON:0001817 ! part of lacrimal gland relationship: BFO:0000050 UBERON:0001817 ! part of lacrimal gland [Term] id: UBERON:0004819 name: kidney epithelium def: "The cellular avascular layer of the kidney luminar surfaces." [MGI:csmith, MP:0004967] subset: pheno_slim synonym: "epithelial tissue of kidney" EXACT [OBOL:automatic] synonym: "epithelium of kidney" EXACT [OBOL:automatic] synonym: "kidney epithelial tissue" EXACT [OBOL:automatic] synonym: "renal epithelium" RELATED [EMAPA:35457] xref: BTO:0000059 xref: CALOHA:TS-0505 xref: EMAPA:35457 xref: MA:0002846 is_a: UBERON:0000483 ! epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: BFO:0000050 UBERON:0002113 ! part of kidney relationship: BFO:0000050 UBERON:0002113 ! part of kidney relationship: RO:0002433 UBERON:0002113 ! contributes to morphology of kidney [Term] id: UBERON:0004820 name: bile duct epithelium def: "Any epithelium that lines one of the bile ducts." [http://orcid.org/0000-0002-6601-2165] subset: pheno_slim synonym: "biliary duct epithelium" EXACT [OBOL:automatic] synonym: "epithelium of bile duct" EXACT [OBOL:automatic] synonym: "epithelium of biliary duct" EXACT [OBOL:automatic] xref: BTO:0000417 xref: MA:0001629 xref: NCIT:C43616 xref: UMLS:C1711208 {source="ncithesaurus:Bile_Duct_Epithelium"} is_a: BFO:0000002 is_a: UBERON:0034932 ! epithelium of biliary system is_a: UBERON:0034969 ! epithelial layer of duct intersection_of: UBERON:0000483 ! epithelium intersection_of: BFO:0000050 UBERON:0002394 ! part of bile duct relationship: BFO:0000050 UBERON:0002394 ! part of bile duct relationship: BFO:0000051 CL:1000488 ! has part cholangiocyte property_value: skos:prefLabel "bile duct epithelium" xsd:string [Term] id: UBERON:0004821 name: pulmonary alveolus epithelium def: "The epithelial layer of the alveoli[MP]. The layer of cells covering the lining of the tiny air sacs at the end of the bronchioles[BTO]." [BTO:0003511, MP:0010898] subset: pheno_slim synonym: "alveolar epithelium" RELATED [EMAPA:35121] synonym: "alveolus epithelial tissue" EXACT [OBOL:automatic] synonym: "alveolus epithelium" EXACT [MA:0001771] synonym: "epithelial tissue of alveolus" EXACT [OBOL:automatic] synonym: "epithelium of alveolus" EXACT [OBOL:automatic] synonym: "epithelium of pulmonary alveolus" EXACT [FMA:63915] synonym: "pulmonary alveolar epithelium" EXACT [FMA:63915] synonym: "pulmonary alveolus epithelium" EXACT [MP:0010898] xref: BTO:0003511 xref: EMAPA:35121 xref: FMA:63915 xref: MA:0001771 xref: NCIT:C12867 is_a: UBERON:0000115 ! lung epithelium is_a: UBERON:0000487 {source="FMA"} ! simple squamous epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: BFO:0000050 UBERON:0002299 ! part of alveolus of lung relationship: BFO:0000050 UBERON:0004894 {source="FMA"} ! part of alveolar wall relationship: BFO:0000051 CL:0002062 {source="FMA"} ! has part pulmonary alveolar type 1 cell relationship: RO:0002433 UBERON:0000115 ! contributes to morphology of lung epithelium relationship: RO:0002433 UBERON:0002299 ! contributes to morphology of alveolus of lung [Term] id: UBERON:0004822 name: extrahepatic bile duct epithelium def: "An epithelium that is part of a extrahepatic bile duct [Automatically generated definition]." [OBOL:automatic] synonym: "epithelial tissue of extrahepatic bile duct" EXACT [OBOL:automatic] synonym: "epithelium of extrahepatic bile duct" EXACT [OBOL:automatic] synonym: "extrahepatic bile duct epithelial tissue" EXACT [OBOL:automatic] xref: EHDAA2:0000742 xref: EHDAA:3051 xref: MA:0002661 xref: NCIT:C43618 xref: UMLS:C1711347 {source="ncithesaurus:Extrahepatic_Bile_Duct_Epithelium"} is_a: UBERON:0004820 ! bile duct epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: BFO:0000050 UBERON:0003703 ! part of extrahepatic bile duct relationship: BFO:0000050 UBERON:0003703 ! part of extrahepatic bile duct property_value: skos:prefLabel "extrahepatic bile duct epithelium" xsd:string [Term] id: UBERON:0004823 name: intrahepatic bile duct epithelium def: "An epithelium that is part of a intrahepatic bile duct [Automatically generated definition]." [OBOL:automatic] synonym: "epithelial tissue of intrahepatic bile duct" EXACT [OBOL:automatic] synonym: "epithelium of intrahepatic bile duct" EXACT [OBOL:automatic] synonym: "intrahepatic bile duct epithelial tissue" EXACT [OBOL:automatic] xref: EHDAA2:0000743 xref: EHDAA:3053 xref: MA:0002662 xref: NCIT:C43617 xref: UMLS:C1708552 {source="ncithesaurus:Intrahepatic_Bile_Duct_Epithelium"} is_a: UBERON:0004820 ! bile duct epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: BFO:0000050 UBERON:0003704 ! part of intrahepatic bile duct relationship: BFO:0000050 UBERON:0003704 ! part of intrahepatic bile duct property_value: skos:prefLabel "intrahepatic bile duct epithelium" xsd:string [Term] id: UBERON:0004827 name: thyroid gland medulla def: "A medulla that is part of a thyroid [Automatically generated definition]." [OBOL:automatic] synonym: "medulla of thyroid" EXACT [OBOL:automatic] synonym: "medulla of thyroid follicle" EXACT [OBOL:automatic] synonym: "medulla of thyroid gland" EXACT [OBOL:automatic] synonym: "medulla of thyroid gland follicle" EXACT [OBOL:automatic] synonym: "thyroid follicle medulla" EXACT [OBOL:automatic] synonym: "thyroid gland follicle medulla" EXACT [OBOL:automatic] synonym: "thyroid medulla" EXACT [OBOL:automatic] xref: EMAPA:37768 {source="MA:th"} xref: MA:0000132 is_a: UBERON:0000958 ! medulla of organ intersection_of: UBERON:0000958 ! medulla of organ intersection_of: BFO:0000050 UBERON:0002046 ! part of thyroid gland relationship: BFO:0000050 UBERON:0002046 ! part of thyroid gland [Term] id: UBERON:0004829 name: urethra skeletal muscle tissue def: "A portion of skeletal muscle tissue that is part of a urethra [Automatically generated definition]." [OBOL:automatic] synonym: "skeletal muscle of urethra" EXACT [OBOL:automatic] synonym: "skeletal muscle tissue of urethra" EXACT [OBOL:automatic] synonym: "urethra skeletal muscle" RELATED [MA:0001690] synonym: "urethra skeletal muscle tissue" EXACT [OBOL:automatic] synonym: "urethral skeletal muscle" RELATED [MA:0001690] xref: EMAPA:37788 {source="MA:th"} xref: MA:0001690 is_a: UBERON:0001134 ! skeletal muscle tissue intersection_of: UBERON:0001134 ! skeletal muscle tissue intersection_of: BFO:0000050 UBERON:0000057 ! part of urethra relationship: BFO:0000050 UBERON:0003829 ! part of urethra muscle tissue [Term] id: UBERON:0004830 name: respiratory system skeletal muscle def: "A portion of skeletal muscle tissue that is part of a respiratory system [Automatically generated definition]." [OBOL:automatic] synonym: "respiratory system skeletal muscle tissue" EXACT [OBOL:automatic] synonym: "skeletal muscle of apparatus respiratorius" EXACT [OBOL:automatic] synonym: "skeletal muscle of respiratory system" EXACT [OBOL:automatic] synonym: "skeletal muscle tissue of apparatus respiratorius" EXACT [OBOL:automatic] synonym: "skeletal muscle tissue of respiratory system" EXACT [OBOL:automatic] xref: EMAPA:37583 {source="MA:th"} xref: MA:0001829 is_a: UBERON:0001134 ! skeletal muscle tissue intersection_of: UBERON:0001134 ! skeletal muscle tissue intersection_of: BFO:0000050 UBERON:0001004 ! part of respiratory system relationship: BFO:0000050 UBERON:0001004 ! part of respiratory system property_value: skos:prefLabel "respiratory system skeletal muscle" xsd:string [Term] id: UBERON:0004831 name: esophagus skeletal muscle def: "A portion of skeletal muscle tissue that is part of a esophagus [Automatically generated definition]." [OBOL:automatic] comment: Most muscle tissue lining the digestive tract is smooth, but part of the externa of the esophagus is skeletal synonym: "esophagus skeletal muscle tissue" EXACT [OBOL:automatic] synonym: "skeletal muscle of esophagus" EXACT [OBOL:automatic] xref: EMAPA:36523 xref: MA:0001572 is_a: UBERON:0001134 ! skeletal muscle tissue intersection_of: UBERON:0001134 ! skeletal muscle tissue intersection_of: BFO:0000050 UBERON:0001043 ! part of esophagus relationship: BFO:0000050 UBERON:0003832 ! part of esophagus muscle property_value: skos:prefLabel "esophagus skeletal muscle" xsd:string [Term] id: UBERON:0004832 name: anal region skeletal muscle def: "A portion of skeletal muscle tissue that is part of an anal region [Automatically generated definition]." [OBOL:automatic] synonym: "anal part of perineum skeletal muscle" EXACT [OBOL:automatic] synonym: "anal part of perineum skeletal muscle tissue" EXACT [OBOL:automatic] synonym: "anal region skeletal muscle tissue" EXACT [OBOL:automatic] synonym: "anal triangle skeletal muscle" EXACT [OBOL:automatic] synonym: "anal triangle skeletal muscle tissue" EXACT [OBOL:automatic] synonym: "skeletal muscle of anal part of perineum" EXACT [OBOL:automatic] synonym: "skeletal muscle of anal region" EXACT [OBOL:automatic] synonym: "skeletal muscle of anal triangle" EXACT [OBOL:automatic] synonym: "skeletal muscle tissue of anal part of perineum" EXACT [OBOL:automatic] synonym: "skeletal muscle tissue of anal region" EXACT [OBOL:automatic] synonym: "skeletal muscle tissue of anal triangle" EXACT [OBOL:automatic] xref: EMAPA:37393 {source="MA:th"} xref: MA:0001530 is_a: UBERON:0001134 ! skeletal muscle tissue intersection_of: UBERON:0001134 ! skeletal muscle tissue intersection_of: BFO:0000050 UBERON:0001353 ! part of anal region relationship: BFO:0000050 UBERON:0001353 ! part of anal region property_value: skos:prefLabel "anal region skeletal muscle" xsd:string [Term] id: UBERON:0004833 name: lip skeletal muscle def: "A portion of skeletal muscle tissue that is part of a lip [Automatically generated definition]." [OBOL:automatic] synonym: "lip skeletal muscle tissue" EXACT [OBOL:automatic] synonym: "skeletal muscle of lip" EXACT [OBOL:automatic] synonym: "skeletal muscle tissue of lip" EXACT [OBOL:automatic] xref: EMAPA:37642 {source="MA:th"} xref: MA:0001578 is_a: UBERON:0001134 ! skeletal muscle tissue intersection_of: UBERON:0001134 ! skeletal muscle tissue intersection_of: BFO:0000050 UBERON:0001833 ! part of lip relationship: BFO:0000050 UBERON:0001833 ! part of lip property_value: IAO:0000116 "this class is derived from MA. Consider re-modeling this as being a muscle that acts on the lips. See: Wikipedia:Lip#Muscles_acting_on_the_lips" xsd:string property_value: skos:prefLabel "lip skeletal muscle" xsd:string [Term] id: UBERON:0004834 name: hepatic duct smooth muscle def: "Smooth muscle tissue in all or part of a hepatic duct." [http://orcid.org/0000-0002-6601-2165] xref: EMAPA:37598 {source="MA:th"} xref: MA:0001640 is_a: UBERON:0001135 ! smooth muscle tissue intersection_of: UBERON:0001135 ! smooth muscle tissue intersection_of: BFO:0000050 UBERON:0005171 ! part of hepatic duct relationship: BFO:0000050 UBERON:0005171 ! part of hepatic duct property_value: skos:prefLabel "hepatic duct smooth muscle" xsd:string [Term] id: UBERON:0004835 name: epididymis smooth muscle def: "A portion of smooth muscle tissue that is part of a epididymis [Automatically generated definition]." [OBOL:automatic] synonym: "epididymis involuntary muscle" EXACT [OBOL:automatic] synonym: "epididymis non-striated muscle" EXACT [OBOL:automatic] synonym: "epididymis smooth muscle tissue" EXACT [OBOL:automatic] synonym: "involuntary muscle of epididymis" EXACT [OBOL:automatic] synonym: "non-striated muscle of epididymis" EXACT [OBOL:automatic] synonym: "smooth muscle of epididymis" EXACT [OBOL:automatic] synonym: "smooth muscle tissue of epididymis" EXACT [OBOL:automatic] xref: MA:0001736 is_a: UBERON:0001135 ! smooth muscle tissue is_a: UBERON:0005156 ! reproductive structure intersection_of: UBERON:0001135 ! smooth muscle tissue intersection_of: BFO:0000050 UBERON:0001301 ! part of epididymis relationship: BFO:0000050 UBERON:0001301 ! part of epididymis [Term] id: UBERON:0004848 name: respiratory system arterial endothelium def: "An endothelium of artery that is part of a respiratory system [Automatically generated definition]." [OBOL:automatic] subset: human_reference_atlas synonym: "apparatus respiratorius arterial endothelium" EXACT [OBOL:automatic] synonym: "apparatus respiratorius artery endothelium" EXACT [OBOL:automatic] synonym: "apparatus respiratorius endothelium of artery" EXACT [OBOL:automatic] synonym: "arterial endothelium of apparatus respiratorius" EXACT [OBOL:automatic] synonym: "arterial endothelium of respiratory system" EXACT [OBOL:automatic] synonym: "artery endothelium of apparatus respiratorius" EXACT [OBOL:automatic] synonym: "artery endothelium of respiratory system" EXACT [OBOL:automatic] synonym: "endothelium of artery of apparatus respiratorius" EXACT [OBOL:automatic] synonym: "endothelium of artery of respiratory system" EXACT [OBOL:automatic] synonym: "respiratory system artery endothelium" EXACT [OBOL:automatic] synonym: "respiratory system endothelium of artery" EXACT [OBOL:automatic] xref: EMAPA:37566 {source="MA:th"} xref: MA:0001801 is_a: UBERON:0001917 ! endothelium of artery is_a: UBERON:0004702 ! respiratory system blood vessel endothelium intersection_of: UBERON:0001917 ! endothelium of artery intersection_of: BFO:0000050 UBERON:0001004 ! part of respiratory system relationship: BFO:0000050 UBERON:0003469 {is_inferred="true", source="https://github.com/obophenotype/uberon/wiki/Inferring-part-of-relationships"} ! part of respiratory system artery property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "respiratory system arterial endothelium" xsd:string [Term] id: UBERON:0004849 name: respiratory system venous endothelium def: "An endothelium of vein that is part of a respiratory system [Automatically generated definition]." [OBOL:automatic] subset: human_reference_atlas synonym: "apparatus respiratorius endothelium of vein" EXACT [OBOL:automatic] synonym: "apparatus respiratorius vein endothelium" EXACT [OBOL:automatic] synonym: "apparatus respiratorius venous endothelium" EXACT [OBOL:automatic] synonym: "endothelium of vein of apparatus respiratorius" EXACT [OBOL:automatic] synonym: "endothelium of vein of respiratory system" EXACT [OBOL:automatic] synonym: "respiratory system endothelium of vein" EXACT [OBOL:automatic] synonym: "respiratory system vein endothelium" EXACT [OBOL:automatic] synonym: "vein endothelium of apparatus respiratorius" EXACT [OBOL:automatic] synonym: "vein endothelium of respiratory system" EXACT [OBOL:automatic] synonym: "venous endothelium of apparatus respiratorius" EXACT [OBOL:automatic] synonym: "venous endothelium of respiratory system" EXACT [OBOL:automatic] xref: EMAPA:37585 {source="MA:th"} xref: MA:0001811 is_a: UBERON:0001919 ! endothelium of vein is_a: UBERON:0004702 ! respiratory system blood vessel endothelium intersection_of: UBERON:0001919 ! endothelium of vein intersection_of: BFO:0000050 UBERON:0001004 ! part of respiratory system relationship: BFO:0000050 UBERON:0003476 ! part of respiratory system venous blood vessel property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "respiratory system venous endothelium" xsd:string [Term] id: UBERON:0004850 name: lymph node endothelium def: "An endothelium that is part of a lymph node [Automatically generated definition]." [OBOL:automatic] synonym: "endothelium of lymph node" EXACT [OBOL:automatic] xref: EMAPA:35526 xref: MA:0000741 is_a: UBERON:0001986 ! endothelium intersection_of: UBERON:0001986 ! endothelium intersection_of: BFO:0000050 UBERON:0000029 ! part of lymph node relationship: BFO:0000050 UBERON:0000029 ! part of lymph node [Term] id: UBERON:0004851 name: aorta endothelium def: "The thin layer of flat cells that line the aorta and form a barrier between circulating blood in the lumen and the rest of the vessel wall." [MGI:csmith, MP:0009864] subset: efo_slim subset: pheno_slim synonym: "adult aorta endothelium" EXACT [OBOL:automatic] synonym: "aortic endothelium" RELATED [BTO:0000394] synonym: "endothelium of adult aorta" EXACT [OBOL:automatic] synonym: "endothelium of aorta" EXACT [OBOL:automatic] synonym: "endothelium of trunk of aortic tree" EXACT [OBOL:automatic] synonym: "endothelium of trunk of systemic arterial tree" EXACT [OBOL:automatic] synonym: "trunk of aortic tree endothelium" EXACT [OBOL:automatic] synonym: "trunk of systemic arterial tree endothelium" EXACT [OBOL:automatic] xref: BTO:0000394 xref: CALOHA:TS-0047 xref: EFO:0002597 xref: EMAPA:35134 xref: MA:0000701 xref: NCIT:C49190 xref: UMLS:C1706824 {source="ncithesaurus:Aorta_Endothelium"} is_a: UBERON:0004638 ! blood vessel endothelium is_a: UBERON:0004700 ! arterial system endothelium intersection_of: UBERON:0001986 ! endothelium intersection_of: BFO:0000050 UBERON:0000947 ! part of aorta relationship: BFO:0000050 UBERON:0000947 ! part of aorta property_value: skos:prefLabel "aorta endothelium" xsd:string [Term] id: UBERON:0004852 name: cardiovascular system endothelium def: "An endothelium that is part of the cardiovascular system." [https://orcid.org/0000-0002-6601-2165] subset: vertebrate_core synonym: "endothelia" RELATED OMO:0003004 [ZFA:0001639] synonym: "vascular endothelia" RELATED OMO:0003004 [XAO:0000356] xref: BTO:0001853 xref: EMAPA:35201 xref: GAID:519 xref: MA:0000717 xref: MESH:D004730 xref: NCIT:C13053 xref: TAO:0002171 xref: UMLS:C0014261 {source="ncithesaurus:Vascular_Endothelium"} xref: VHOG:0001217 xref: XAO:0000356 xref: ZFA:0001639 is_a: UBERON:0001986 ! endothelium intersection_of: UBERON:0001986 ! endothelium intersection_of: BFO:0000050 UBERON:0004535 ! part of cardiovascular system relationship: BFO:0000050 UBERON:0004535 ! part of cardiovascular system property_value: IAO:0000116 "consider merging with 'endothelium'" xsd:string property_value: skos:prefLabel "cardiovascular system endothelium" xsd:string [Term] id: UBERON:0004854 name: gastrointestinal system mesentery def: "A mesentery that is part of a digestive system [Automatically generated definition]." [OBOL:automatic] subset: pheno_slim synonym: "digestive system mesentery" EXACT [OBOL:automatic] synonym: "mesentery of digestive system" EXACT [OBOL:automatic] synonym: "mesentery of gastrointestinal system" EXACT [OBOL:automatic] xref: EMAPA:37068 {source="MA:th"} xref: MA:0001900 is_a: UBERON:0002095 ! mesentery is_a: UBERON:0004782 ! gastrointestinal system serosa intersection_of: UBERON:0002095 ! mesentery intersection_of: BFO:0000050 UBERON:0005409 ! part of alimentary part of gastrointestinal system [Term] id: UBERON:0004857 name: skeletal muscle connective tissue def: "A connective tissue that surrounds a skeletal muscle tissue." [OBOL:automatic] synonym: "connective tissue of skeletal muscle" EXACT [OBOL:automatic] synonym: "connective tissue of skeletal muscle tissue" EXACT [OBOL:automatic] synonym: "portion of connective tissue of skeletal muscle" EXACT [OBOL:automatic] synonym: "portion of connective tissue of skeletal muscle tissue" EXACT [OBOL:automatic] synonym: "skeletal muscle interstitial tissue" RELATED [MA:0002868] synonym: "skeletal muscle interstitum" RELATED [MA:0002868] synonym: "skeletal muscle portion of connective tissue" EXACT [OBOL:automatic] synonym: "skeletal muscle textus connectivus" EXACT [OBOL:automatic] synonym: "skeletal muscle tissue connective tissue" EXACT [OBOL:automatic] synonym: "skeletal muscle tissue portion of connective tissue" EXACT [OBOL:automatic] synonym: "skeletal muscle tissue textus connectivus" EXACT [OBOL:automatic] synonym: "textus connectivus of skeletal muscle" EXACT [OBOL:automatic] synonym: "textus connectivus of skeletal muscle tissue" EXACT [OBOL:automatic] xref: EMAPA:37743 {source="MA:th"} xref: MA:0002868 is_a: UBERON:0002384 ! connective tissue intersection_of: UBERON:0002384 ! connective tissue intersection_of: RO:0002221 UBERON:0001134 ! surrounds skeletal muscle tissue relationship: RO:0002221 UBERON:0001134 ! surrounds skeletal muscle tissue property_value: skos:prefLabel "skeletal muscle connective tissue" xsd:string [Term] id: UBERON:0004859 name: eye gland def: "A gland that is part of a eye. The eye is a compound unit which depending on the species may consist of an eyeballs plus associated ducts and integumentary structures. Eye glands therefore include the various types of lacrimal gland, the various types of apocrine and sebaceous glands associated with the eyelid." [http://orcid.org/0000-0002-6601-2165] comment: Examples: harderian gland, accessory lacrimal gland, gland of Moll, gland of Zeis, nictitating membrane glands subset: organ_slim synonym: "eye-associated gland" EXACT [http://orcid.org/0000-0002-6601-2165] synonym: "gland of eye" EXACT [OBOL:automatic] xref: EMAPA:35334 xref: MA:0000267 is_a: UBERON:0002530 ! gland intersection_of: UBERON:0002530 ! gland intersection_of: BFO:0000050 UBERON:0000970 ! part of eye relationship: BFO:0000050 UBERON:0000970 ! part of eye property_value: skos:prefLabel "eye gland" xsd:string [Term] id: UBERON:0004861 name: right lung alveolus def: "An alveolus that is part of a right lung [Automatically generated definition]." [OBOL:automatic] synonym: "alveolus of right lung" EXACT [OBOL:automatic] xref: EMAPA:35997 xref: MA:0001786 xref: NCIT:C49278 xref: UMLS:C1709959 {source="ncithesaurus:Right_Lung_Alveolus"} is_a: UBERON:0002299 ! alveolus of lung intersection_of: UBERON:0003215 ! alveolus intersection_of: BFO:0000050 UBERON:0002167 ! part of right lung relationship: BFO:0000050 UBERON:0006526 ! part of right lung alveolar system [Term] id: UBERON:0004862 name: left lung alveolus def: "An alveolus that is part of a left lung [Automatically generated definition]." [OBOL:automatic] synonym: "alveolus of left lung" EXACT [OBOL:automatic] synonym: "alveolus of lobe of left lung" EXACT [OBOL:automatic] xref: EMAPA:19182 xref: MA:0001777 xref: NCIT:C49251 xref: UMLS:C1708673 {source="ncithesaurus:Left_Lung_Alveolus"} is_a: UBERON:0002299 ! alveolus of lung intersection_of: UBERON:0003215 ! alveolus intersection_of: BFO:0000050 UBERON:0002168 ! part of left lung relationship: BFO:0000050 UBERON:0006525 ! part of left lung alveolar system [Term] id: UBERON:0004863 name: thoracic sympathetic nerve trunk def: "A sympathetic nerve trunk that is part of a thorax [Automatically generated definition]." [OBOL:automatic] synonym: "nerve trunk of sympathetic nervous system of thorax" EXACT [OBOL:automatic] synonym: "nerve trunk of sympathetic part of autonomic division of nervous system of thorax" EXACT [OBOL:automatic] synonym: "sympathetic nerve trunk of thorax" EXACT [OBOL:automatic] synonym: "sympathetic nervous system nerve trunk of thorax" EXACT [OBOL:automatic] synonym: "thoracic part of sympathetic trunk" EXACT [FMA:6262] synonym: "thoracic sympathetic chain" EXACT [FMA:6262] synonym: "thoracic sympathetic trunk" RELATED [FMA:6262] synonym: "thorax nerve trunk of sympathetic nervous system" EXACT [OBOL:automatic] synonym: "thorax nerve trunk of sympathetic part of autonomic division of nervous system" EXACT [OBOL:automatic] synonym: "thorax sympathetic nerve trunk" EXACT [OBOL:automatic] synonym: "thorax sympathetic nervous system nerve trunk" EXACT [OBOL:automatic] xref: EMAPA:37657 {source="MA:th"} xref: FMA:6262 xref: MA:0001165 xref: NCIT:C52827 xref: UMLS:C1710393 {source="ncithesaurus:Thoracic_Sympathetic_Nerve_Trunk"} is_a: UBERON:0004295 ! sympathetic nerve trunk intersection_of: UBERON:0004295 ! sympathetic nerve trunk intersection_of: BFO:0000050 UBERON:0000915 ! part of thoracic segment of trunk relationship: BFO:0000050 UBERON:0000915 ! part of thoracic segment of trunk [Term] id: UBERON:0004864 name: vasculature of retina def: "A vasculature that is part of a retina [Automatically generated definition]." [OBOL:automatic] subset: human_reference_atlas subset: pheno_slim synonym: "retina vasculature" EXACT [GO:0061298] synonym: "retina vasculature of camera-type eye" EXACT [GO:0061298] synonym: "retinal blood vessels" EXACT [FMA:76552] synonym: "retinal blood vessels set" EXACT [FMA:76552] synonym: "retinal vasculature" EXACT [OBOL:automatic] synonym: "set of blood vessels of retina" EXACT [OBOL:automatic] synonym: "set of retinal blood vessels" EXACT [FMA:76552] synonym: "vasa sanguinea retinae" EXACT OMO:0003011 [FMA:76552, FMA:TA] xref: FMA:76552 xref: MESH:D012171 is_a: UBERON:0002203 ! vasculature of eye is_a: UBERON:0036302 ! vasculature of central nervous system plus retina intersection_of: UBERON:0002049 ! vasculature intersection_of: BFO:0000050 UBERON:0000966 ! part of retina relationship: BFO:0000050 UBERON:0000966 ! part of retina property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "vasculature of retina" xsd:string [Term] id: UBERON:0004867 name: orbital cavity def: "Anatomical cavity bounded by the orbital region of the cranium and forming the location of some or all of the eye." [http://orcid.org/0000-0002-6601-2165] synonym: "orbit" RELATED [AAO:0000343] xref: AAO:0000343 xref: FMA:84961 xref: SCTID:280541000 xref: Wikipedia:Orbit_(anatomy) xref: ZFA:0005558 is_a: UBERON:0002553 ! anatomical cavity intersection_of: UBERON:0002553 ! anatomical cavity intersection_of: RO:0002572 UBERON:0001697 ! luminal space of orbit of skull relationship: RO:0002572 UBERON:0001697 ! luminal space of orbit of skull property_value: skos:prefLabel "orbital cavity" xsd:string [Term] id: UBERON:0004871 name: somatic layer of lateral plate mesoderm def: "Layer of lateral plate mesoderm that forms the future body wall - underlies the ectoderm[WP]." [Wikipedia:Lateral_plate_mesoderm#Division_into_layers] subset: pheno_slim synonym: "outer layer of lateral plate mesoderm" EXACT [] synonym: "parietal mesoderm" RELATED [ISBN:9780878932504] synonym: "somatic mesoderm" RELATED [BILA:0000047] xref: AAO:0011100 xref: BILA:0000047 xref: FMA:295570 xref: Wikipedia:Lateral_plate_mesoderm#Division_into_layers xref: XAO:0000271 is_a: UBERON:0002050 ! embryonic structure relationship: BFO:0000050 UBERON:0003081 ! part of lateral plate mesoderm property_value: IAO:0000116 "check BILA" xsd:string [Term] id: UBERON:0004872 name: splanchnic layer of lateral plate mesoderm def: "Layer of lateral plate mesoderm that forms the circulatory system and future gut wall - overlies endoderm[WP]." [Wikipedia:Lateral_plate_mesoderm#Division_into_layers] subset: pheno_slim synonym: "inner layer of lateral plate mesoderm" EXACT [] synonym: "splanchnic mesoderm" RELATED [ISBN:9780878932504] synonym: "visceral mesoderm" BROAD [BILA:0000044, http://www.drugs.com/dict/visceral-mesoderm.html, http://www.stedmans.com/] xref: AAO:0011102 xref: BILA:0000044 xref: FMA:295568 xref: Wikipedia:Lateral_plate_mesoderm#Division_into_layers xref: XAO:0000276 is_a: UBERON:0002050 ! embryonic structure relationship: BFO:0000050 UBERON:0003081 ! part of lateral plate mesoderm property_value: skos:prefLabel "splanchnic layer of lateral plate mesoderm" xsd:string [Term] id: UBERON:0004873 name: splanchnopleure def: "A structure created during embryogenesis when the lateral mesoderm splits into two layers - the inner (or splanchnic) layer adheres to the endoderm, and with it forms the splanchnopleure[WP]." [Wikipedia:Splanchnopleure] synonym: "ventral splanchnic mesoderm" RELATED [Wikipedia:Intraembryonic_coelom] xref: EHDAA2:0001903 xref: EHDAA:383 xref: EMAPA:16181 xref: FMA:295564 xref: NCIT:C34303 xref: UMLS:C1519472 {source="ncithesaurus:Splanchnopleure"} xref: VHOG:0000558 xref: Wikipedia:Splanchnopleure is_a: UBERON:0002050 ! embryonic structure relationship: BFO:0000050 UBERON:0003081 {source="EHDAA2"} ! part of lateral plate mesoderm relationship: RO:0002131 UBERON:0000925 ! overlaps endoderm property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/2/28/Gray16.png" xsd:anyURI property_value: IAO:0000116 "TODO - check relationship to LPM" xsd:string property_value: skos:prefLabel "splanchnopleure" xsd:string [Term] id: UBERON:0004874 name: somatopleure def: "A structure created during embryogenesis when the lateral mesoderm splits into two layers - the outer (or somatic) layer becomes applied to the inner surface of the ectoderm, and with it forms the somatopleure.[WP]." [Wikipedia:Somatopleure] xref: EHDAA2:0001847 xref: EHDAA:381 xref: EMAPA:16180 xref: FMA:295566 xref: NCIT:C34301 xref: UMLS:C1519423 {source="ncithesaurus:Somatopleure"} xref: VHOG:0000557 xref: Wikipedia:Somatopleure is_a: UBERON:0002050 ! embryonic structure relationship: BFO:0000050 UBERON:0003081 {source="EHDAA2"} ! part of lateral plate mesoderm relationship: RO:0002131 UBERON:0000924 ! overlaps ectoderm property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/2/28/Gray16.png" xsd:anyURI property_value: skos:prefLabel "somatopleure" xsd:string [Term] id: UBERON:0004875 name: nephrogenic cord def: "A portion of the urogenital ridge which is the source of much of the urinary system[WP]." [Wikipedia:Nephrogenic_cord] comment: part_of or develops_from urogenital ridge? synonym: "chorda nephrogenica" RELATED OMO:0003011 [Wikipedia:Nephrogenic_cord] xref: FMA:72168 xref: NCIT:C34219 xref: SCTID:361405003 xref: UMLS:C1283944 {source="ncithesaurus:Nephrogenic_Cord"} xref: Wikipedia:Nephrogenic_cord is_a: BFO:0000002 is_a: UBERON:0002050 ! embryonic structure relationship: RO:0002202 UBERON:0004876 ! develops from urogenital fold [Term] id: UBERON:0004876 name: urogenital fold def: "One of of the pair of folds derived from the cloacal folds which give rise to a portion of the external genitalia; in male embryos they close over the urethral plate and fuse to form the spongy (penile) urethra and ventral aspect of the penis, not including the glans; failure of fusion of the urethral folds leads to hypospadias; in female embryos they fuse only anterior to the anus and form the labia minora[MP]." [MP:0011835, MP:anna, Wikipedia:Urogenital_folds] subset: pheno_slim synonym: "urethral fold" EXACT [EMAPA:30888] synonym: "urogenital fold" EXACT [EHDAA2:0004022, MP:0011835] synonym: "urogenital ridge" RELATED INCONSISTENT [MP:0011835] xref: EHDAA2:0004022 xref: EMAPA:30888 xref: FMA:321919 xref: Wikipedia:Urogenital_folds is_a: BFO:0000002 is_a: UBERON:0006598 ! presumptive structure relationship: BFO:0000050 UBERON:0009196 {source="EHDAA2"} ! part of indifferent external genitalia relationship: RO:0002202 UBERON:0003064 {source="Wikipedia"} ! develops from intermediate mesoderm relationship: RO:0002202 UBERON:0012292 {source="EHDAA2"} ! develops from embryonic cloacal fold relationship: RO:0002387 UBERON:0004176 ! has potential to develop into external genitalia [Term] id: UBERON:0004877 name: visceral endoderm def: "Visceral endoderm, a population of extraembyonic endoderm, is an extraembryonic tissue that functions in a regulatory capacity but does not contribute directly to the formation of any adult organs[PMID:15905405]. primitive endoderm-derived tissue which remains in contact with and surrounds the extra-embryonic ectoderm and the epiblast and provides signals for the differentiation and patterning of the epiblast; a small number of visceral endoderm cells also contribute to the endoderm of the embryonic gut[MP]." [MP:0011186, PMID:15905405] subset: pheno_slim xref: BTO:0003487 xref: EMAPA:16058 is_a: UBERON:0004119 ! endoderm-derived structure is_a: UBERON:0005292 {source="BTO"} ! extraembryonic tissue [Term] id: UBERON:0004880 name: chordamesoderm def: "The central region of trunk mesoderm. This tissue forms the notochord." [https://orcid.org/0000-0002-6601-2165] subset: efo_slim subset: pheno_slim synonym: "axial chorda mesoderm" EXACT [ZFA:0000091] synonym: "chorda mesoderm" EXACT [] synonym: "dorsal mesoderm" EXACT [https://github.com/obophenotype/uberon/wiki/The-neural-crest] synonym: "presumptive notochord" EXACT [ZFA:0000091] xref: AAO:0000478 xref: EFO:0003426 xref: TAO:0000091 xref: ZFA:0000091 is_a: UBERON:0002050 ! embryonic structure relationship: BFO:0000050 UBERON:0003068 ! part of axial mesoderm property_value: skos:prefLabel "chordamesoderm" xsd:string [Term] id: UBERON:0004883 name: lung mesenchyme def: "The mass of tissue made up of mesenchymal cells in the lung." [GO:0060484] subset: human_reference_atlas subset: pheno_slim synonym: "lung-associated mesenchyme" EXACT [GO:0060484] synonym: "mesenchyme of lung" EXACT [OBOL:automatic] synonym: "pulmonary mesenchyme" EXACT [GO:0060484] xref: EMAPA:32866 is_a: UBERON:0003104 ! mesenchyme is_a: UBERON:0004120 ! mesoderm-derived structure intersection_of: UBERON:0003104 ! mesenchyme intersection_of: BFO:0000050 UBERON:0002048 ! part of lung relationship: BFO:0000050 UBERON:0002048 ! part of lung relationship: RO:0002202 UBERON:0003081 ! develops from lateral plate mesoderm property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "lung mesenchyme" xsd:string [Term] id: UBERON:0004884 name: lobar bronchus mesenchyme def: "The mass of tissue composed of mesenchymal cells in the lobar bronchus.." [GO:0060483] subset: human_reference_atlas synonym: "mesenchyme of lobar bronchus" EXACT [OBOL:automatic] xref: EMAPA:32698 is_a: UBERON:0004883 ! lung mesenchyme intersection_of: UBERON:0003104 ! mesenchyme intersection_of: BFO:0000050 UBERON:0002183 ! part of lobar bronchus relationship: BFO:0000050 UBERON:0002183 ! part of lobar bronchus relationship: BFO:0000051 CL:0019019 ! has part tracheobronchial smooth muscle cell property_value: RO:0002175 NCBITaxon:9606 property_value: terms:contributor https://orcid.org/0000-0001-6677-8489 [Term] id: UBERON:0004889 name: lobar bronchus vasculature def: "Vasculature that is composed of the tubule structures that carry blood or lymph in the lungs." [LG:0012616] is_a: UBERON:0000102 ! lung vasculature intersection_of: UBERON:0002049 ! vasculature intersection_of: BFO:0000050 UBERON:0002183 ! part of lobar bronchus relationship: BFO:0000050 UBERON:0002183 ! part of lobar bronchus [Term] id: UBERON:0004893 name: interalveolar septum def: "A the thin septum that separates adjacent pulmonary alveoli, containing connective tissue constituents of the respiratory tissue and the capillary network of the blood supply of the lung." [LG:0012625, Wikipedia:Alveolar_septum] subset: pheno_slim synonym: "alveolar septum" EXACT [https://orcid.org/0000-0002-6601-2165] synonym: "septum interalveolare" RELATED [BTO:0003149] xref: BTO:0003149 xref: EMAPA:35433 xref: MA:0000421 xref: NCIT:C49473 xref: UMLS:C1706784 {source="ncithesaurus:Alveolar_Septum"} xref: Wikipedia:Alveolar_septum is_a: UBERON:0003037 ! septum intersection_of: UBERON:0003037 ! septum intersection_of: RO:0002220 UBERON:0002299 ! adjacent to alveolus of lung relationship: BFO:0000050 UBERON:0006524 ! part of alveolar system relationship: RO:0002220 UBERON:0002299 ! adjacent to alveolus of lung [Term] id: UBERON:0004894 name: alveolar wall def: "A wall that contains the alveoli." [LG:0012626, MP:0010903] subset: pheno_slim synonym: "alveolus wall" RELATED [EMAPA:35120] synonym: "pulmonary alveolar wall" EXACT [FMA:14117] synonym: "pulmonary interalveolar septum" EXACT [FMA:14117] synonym: "wall of pulmonary alveolus" EXACT [FMA:14117] xref: BTO:0002543 xref: EMAPA:35120 xref: FMA:14117 xref: MA:0002568 xref: NCIT:C13085 xref: SCTID:361965008 xref: UMLS:C0225695 {source="ncithesaurus:Alveolar_Wall"} is_a: UBERON:0000060 ! anatomical wall intersection_of: UBERON:0000060 ! anatomical wall intersection_of: BFO:0000050 UBERON:0002299 ! part of alveolus of lung relationship: BFO:0000050 UBERON:0002299 ! part of alveolus of lung relationship: RO:0002433 UBERON:0002299 ! contributes to morphology of alveolus of lung [Term] id: UBERON:0004895 name: alveolar smooth muscle def: "Alveolar smooth muscle is a type of non-striated muscle, found within the walls of the alveolus." [LG:0012628] xref: EMAPA:35122 xref: MA:0002759 is_a: UBERON:0004233 ! lower respiratory tract smooth muscle intersection_of: UBERON:0001135 ! smooth muscle tissue intersection_of: BFO:0000050 UBERON:0002299 ! part of alveolus of lung relationship: BFO:0000050 UBERON:0002299 ! part of alveolus of lung [Term] id: UBERON:0004901 name: right lung lobar bronchus mesenchyme def: "The right lung lobar bronchus mesenchyme is a type of tissue made up of loosely-packed mesenchymal cells in the right lung lobar bronchus." [LG:0012681] xref: EMAPA:17665 is_a: UBERON:0004884 ! lobar bronchus mesenchyme is_a: UBERON:0009603 ! right lung associated mesenchyme intersection_of: UBERON:0003104 ! mesenchyme intersection_of: BFO:0000050 UBERON:0002167 ! part of right lung intersection_of: BFO:0000050 UBERON:0002183 ! part of lobar bronchus [Term] id: UBERON:0004902 name: urogenital sinus epithelium def: "The fetal urogenital sinus (from which the prostate derives) is a simple cylinder of stratified basal epithelium, surrounded by mesenchyme and positioned between the embryonic bladder and pelvic urethra." [PMID:18977204] synonym: "epithelium of urogenital sinus" EXACT [OBOL:automatic] synonym: "UGE" EXACT [PMID:18977204] xref: EHDAA2:0004061 xref: EMAPA:31509 is_a: UBERON:0009846 ! embryonic cloacal epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: BFO:0000050 UBERON:0000164 ! part of primitive urogenital sinus relationship: BFO:0000050 UBERON:0000164 ! part of primitive urogenital sinus relationship: RO:0002202 UBERON:0009846 {source="EHDAA2"} ! develops from embryonic cloacal epithelium [Term] id: UBERON:0004903 name: bronchoalveolar duct junction def: "A branch point connecting the respiratory bronchioles to the alveolar ducts[MP]." [MP:0004390] subset: pheno_slim xref: EMAPA:37448 {source="MA:th"} is_a: UBERON:0007651 ! anatomical junction relationship: BFO:0000050 UBERON:0001004 ! part of respiratory system relationship: RO:0002176 UBERON:0002173 ! connects pulmonary alveolar duct relationship: RO:0002176 UBERON:0002188 ! connects respiratory bronchiole [Term] id: UBERON:0004904 name: neuron projection bundle connecting eye with brain def: "A neuron projection bundle that connects the retina or its analog in the eye with the brain. This includes the vertebrate optic nerve (not truly a nerve) as well as analogous structures such as the Bolwig nerve in Drosophila." [http://orcid.org/0000-0002-6601-2165] comment: for the vertebrate-specific structure, see UBERON:0000941 (cranial nerve II) subset: grouping_class subset: pheno_slim synonym: "optic nerve" BROAD [BTO:0000966] synonym: "optic nerve (generic)" EXACT [] xref: BTO:0000966 xref: EV:0100351 xref: FBbt:00001956 {sssom:mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"} xref: TADS:0000232 is_a: UBERON:0000122 ! neuron projection bundle intersection_of: UBERON:0000122 ! neuron projection bundle intersection_of: extends_fibers_into UBERON:0000955 ! brain intersection_of: extends_fibers_into UBERON:0005388 ! photoreceptor array relationship: BFO:0000050 UBERON:0002104 ! part of visual system relationship: extends_fibers_into UBERON:0000955 ! brain relationship: extends_fibers_into UBERON:0005388 ! photoreceptor array property_value: skos:prefLabel "neuron projection bundle connecting eye with brain" xsd:string [Term] id: UBERON:0004905 name: articulation def: "Anatomical structure that connects two or more adjacent skeletal elements or hardened body parts." [http://orcid.org/0000-0002-6601-2165] subset: grouping_class synonym: "joint" NARROW [] xref: FBbt:00005811 {sssom:mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"} is_a: UBERON:0034921 ! multi organ part structure relationship: BFO:0000050 UBERON:0004770 ! part of articular system property_value: skos:prefLabel "articulation" xsd:string [Term] id: UBERON:0004906 name: ectodermal part of digestive tract def: "A portion of the gut that is derived from ectoderm." [GO:0007439] synonym: "ectodermal gut" EXACT [] synonym: "gut ectoderm" EXACT [EMAPA:32930] is_a: UBERON:0004121 ! ectoderm-derived structure is_a: UBERON:0004921 ! subdivision of digestive tract intersection_of: UBERON:0004921 ! subdivision of digestive tract intersection_of: BFO:0000050 UBERON:0001555 ! part of digestive tract intersection_of: RO:0002202 UBERON:0000924 ! develops from ectoderm property_value: skos:prefLabel "ectodermal part of digestive tract" xsd:string [Term] id: UBERON:0004907 name: lower digestive tract def: "The region of the digestive tract extending from the beginning of the intestines to the anus[GO - gut definition]." [Wikipedia:Alimentary_canal#Upper_gastrointestinal_tract] subset: uberon_slim synonym: "gut" BROAD [GO:0048565] synonym: "lower gastrointestinal tract" EXACT [] synonym: "lower GI tract" EXACT [] xref: FMA:49179 xref: galen:LowerGastrointestinalTract xref: NCIT:C33010 xref: SCTID:279973004 xref: UMLS:C0226875 {source="ncithesaurus:Lower_Gastrointestinal_Tract"} xref: Wikipedia:Alimentary_canal#Upper_gastrointestinal_tract is_a: BFO:0000002 is_a: UBERON:0004921 ! subdivision of digestive tract relationship: BFO:0000050 UBERON:0005409 ! part of alimentary part of gastrointestinal system relationship: RO:0002202 UBERON:0001046 ! develops from hindgut property_value: skos:prefLabel "lower digestive tract" xsd:string [Term] id: UBERON:0004908 name: upper digestive tract def: "The region of the digestive tract extending from the mouth cavity through pharynx esophagus stomach and duodenum." [Wikipedia:Alimentary_canal#Upper_gastrointestinal_tract] subset: uberon_slim synonym: "upper gastrointestinal tract" EXACT [] synonym: "upper GI tract" EXACT [] xref: FMA:49177 xref: galen:UpperGastrointestinalTract xref: NCIT:C33837 xref: SCTID:181244000 xref: UMLS:C0226874 {source="ncithesaurus:Upper_Gastrointestinal_Tract"} xref: Wikipedia:Alimentary_canal#Upper_gastrointestinal_tract is_a: BFO:0000002 is_a: UBERON:0004921 ! subdivision of digestive tract relationship: RO:0002202 UBERON:0001041 ! develops from foregut property_value: skos:prefLabel "upper digestive tract" xsd:string [Term] id: UBERON:0004909 name: epithelium of gonad def: "An epithelium surrounding a gonad." [OBOL:automatic] synonym: "gonad epithelium" EXACT [OBOL:automatic] synonym: "gonadal epithelium" EXACT [OBOL:automatic] synonym: "gonadal sheath" RELATED [FBbt:00004859] xref: EHDAA:4032 xref: EHDAA:5931 xref: NCIT:C32676 xref: UMLS:C1517534 {source="ncithesaurus:Germinal_Epithelium"} is_a: UBERON:0000483 ! epithelium is_a: UBERON:0005156 ! reproductive structure intersection_of: UBERON:0000483 ! epithelium intersection_of: BFO:0000050 UBERON:0000991 ! part of gonad relationship: BFO:0000050 UBERON:0000991 ! part of gonad property_value: IAO:0000116 "after reasoning this should subsume the more specific germinal epithelium classes. We include the fly structure here although it is not clear if the sheath is an epithelium or a multi-tissue structure that includes epithelium as parts" xsd:string property_value: skos:prefLabel "epithelium of gonad" xsd:string [Term] id: UBERON:0004910 name: epithelium of male gonad def: "An epithelium surrounding a testis." [OBOL:automatic] synonym: "testis epithelium" EXACT [OBOL:automatic] xref: BTO:0001364 xref: EMAPA:17973 is_a: UBERON:0004909 ! epithelium of gonad intersection_of: UBERON:0000483 ! epithelium intersection_of: BFO:0000050 UBERON:0000473 ! part of testis relationship: BFO:0000050 UBERON:0000473 ! part of testis property_value: IAO:0000116 "after reasoning this should subsume the more specific germinal epithelium classes. We include the fly structure here although it is not clear if the sheath is an epithelium or a multi-tissue structure that includes epithelium as parts" xsd:string [Term] id: UBERON:0004911 name: epithelium of female gonad def: "An epithelium surrounding an ovary." [OBOL:automatic] synonym: "ovarian epithelium" EXACT [OBOL:automatic] synonym: "ovarian sheath" NARROW SENSU [FBbt:00004896] synonym: "ovary epithelium" EXACT [OBOL:automatic] xref: BTO:0003661 is_a: UBERON:0004909 ! epithelium of gonad intersection_of: UBERON:0000483 ! epithelium intersection_of: BFO:0000050 UBERON:0000992 ! part of ovary relationship: BFO:0000050 UBERON:0000992 ! part of ovary property_value: IAO:0000116 "after reasoning this should subsume the more specific germinal epithelium classes. We include the fly structure here although it is not clear if the sheath is an epithelium or a multi-tissue structure that includes epithelium as parts" xsd:string property_value: skos:prefLabel "epithelium of female gonad" xsd:string [Term] id: UBERON:0004912 name: biliary bud synonym: "hepatic diverticulum" RELATED [EMAPA:16561] xref: EHDAA2:0000171 xref: EMAPA:16561 xref: EMAPA_RETIRED:16565 xref: VHOG:0001351 is_a: UBERON:0004185 ! endodermal part of digestive tract is_a: UBERON:0007499 {source="EHDAA2"} ! epithelial sac is_a: UBERON:0009497 ! epithelium of foregut-midgut junction is_a: UBERON:0009854 ! digestive tract diverticulum relationship: BFO:0000050 UBERON:0002423 {source="EHDAA2"} ! part of hepatobiliary system relationship: RO:0002202 UBERON:0004161 {source="EHDAA2-modified"} ! develops from septum transversum property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/4/4f/Gray1088.png" xsd:anyURI property_value: skos:prefLabel "biliary bud" xsd:string [Term] id: UBERON:0004913 name: hepatopancreatic ampulla def: "A dilation of the duodenal papilla that is the opening of the juncture of the common bile duct and the main pancreatic duct." [Wikipedia:Ampulla_of_Vater] subset: human_reference_atlas subset: vertebrate_core synonym: "ampulla biliaropancreatica" EXACT OMO:0003011 [FMA:15076, FMA:TA] synonym: "ampulla hepatopancreatica" RELATED OMO:0003011 [Wikipedia:Ampulla_of_Vater] synonym: "ampulla of bile duct" EXACT [FMA:15076] synonym: "ampulla of Vater" EXACT [] synonym: "ampulla Vaterii" RELATED OMO:0003011 [Wikipedia:Ampulla_of_Vater] synonym: "biliaropancreatic ampulla" EXACT [] synonym: "papilla duodeni major" RELATED [ZFA:0005167] synonym: "papilla Vateri" EXACT [ZFA:0005167] synonym: "Vater's ampulla" EXACT [] xref: CALOHA:TS-2348 xref: FMA:15076 xref: GAID:283 xref: galen:AmpullaOfVater xref: MESH:D014670 xref: NCIT:C13011 xref: SCTID:362200007 xref: TAO:0005167 xref: UMLS:C0042425 {source="ncithesaurus:Ampulla_of_Vater"} xref: Wikipedia:Ampulla_of_Vater xref: ZFA:0005167 is_a: UBERON:0002394 ! bile duct intersection_of: UBERON:0000058 ! duct intersection_of: BFO:0000050 UBERON:0001174 ! part of common bile duct intersection_of: BFO:0000050 UBERON:0004914 ! part of duodenal papilla relationship: BFO:0000050 UBERON:0001174 ! part of common bile duct relationship: BFO:0000050 UBERON:0004914 ! part of duodenal papilla property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/1/1e/Biliary_system_new.svg" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "hepatopancreatic ampulla" xsd:string [Term] id: UBERON:0004914 name: duodenal papilla def: "One of the two small elevations on the mucosa of the duodenum, the major at the entrance of the conjoined pancreatic and common bile ducts and the minor at the entrance of the accessory pancreatic duct." [http://medical-dictionary.thefreedictionary.com/duodenal+papilla] synonym: "papilla duodenalis" EXACT [] synonym: "papilla duodeni" RELATED OMO:0003011 [Wikipedia:Major_duodenal_papilla] synonym: "papilla of duodenum" EXACT [] xref: EMAPA:18662 xref: FMA:15953 xref: MA:0003107 xref: NCIT:C119578 xref: SCTID:245389007 is_a: UBERON:0034944 ! zone of organ relationship: BFO:0000050 UBERON:0000320 ! part of duodenal mucosa property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/4/43/Gray1057.png" xsd:anyURI property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/small-intestine-male/v1.2/assets/3d-vh-m-small-intestine.glb" xsd:anyURI property_value: skos:prefLabel "duodenal papilla" xsd:string [Term] id: UBERON:0004915 name: sphincter of hepatopancreatic ampulla def: "Muscular valve that controls the flow of digestive juices (bile and pancreatic juice) through the ampulla of Vater into the second part of the duodenum. Relaxed by the hormone Cholecystokinin (CCK) via vasoactive intestinal polypeptide (VIP).[WP]." [Wikipedia:Sphincter_of_ampulla] subset: human_reference_atlas synonym: "hepatopancreatic ampullary sphincter" EXACT [FMA:15077] synonym: "musculus sphincter ampullae" EXACT [FMA:15077] synonym: "musculus sphincter ampullae hepatopancreatica" EXACT OMO:0003011 [FMA:15077, FMA:TA] synonym: "Oddi's sphincter" EXACT [] synonym: "sphincter of ampulla of vater" EXACT [FMA:15077] synonym: "sphincter of Oddi" EXACT [] xref: EMAPA:18663 xref: FMA:15077 xref: GAID:285 xref: MESH:D009803 xref: NCIT:C13065 xref: SCTID:181271000 xref: UMLS:C0028872 {source="ncithesaurus:Sphincter_of_Oddi"} xref: Wikipedia:Sphincter_of_ampulla is_a: UBERON:0011185 ! gastrointestinal sphincter intersection_of: UBERON:0004590 ! sphincter muscle intersection_of: BFO:0000050 UBERON:0004913 ! part of hepatopancreatic ampulla relationship: BFO:0000050 UBERON:0004913 ! part of hepatopancreatic ampulla property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/4/43/Gray1057.png" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "sphincter of hepatopancreatic ampulla" xsd:string [Term] id: UBERON:0004916 name: anal sphincter def: "A sphincter muscle that is part of a anal region." [OBOL:automatic] synonym: "anal region sphincter" EXACT [] synonym: "sphincter analia" EXACT [] xref: EMAPA:36052 is_a: UBERON:0004590 ! sphincter muscle intersection_of: UBERON:0004590 ! sphincter muscle intersection_of: BFO:0000050 UBERON:0001353 ! part of anal region relationship: BFO:0000050 UBERON:0001353 ! part of anal region relationship: RO:0002216 GO:0030421 ! capable of part of defecation property_value: skos:prefLabel "anal sphincter" xsd:string [Term] id: UBERON:0004917 name: urethral sphincter def: "A sphincter muscle surrounding the urethra." [Wikipedia:Urethral_sphincter] synonym: "sphincter muscle of urethra" EXACT [] synonym: "sphincter of urethra" EXACT [] synonym: "sphincter urethrae" EXACT [] synonym: "urethral sphincter muscle" EXACT [] xref: EMAPA:37789 {source="MA:th"} xref: MA:0002650 xref: SCTID:277855007 xref: SCTID:277857004 xref: Wikipedia:Urethral_sphincter is_a: UBERON:0003829 ! urethra muscle tissue is_a: UBERON:0004590 ! sphincter muscle intersection_of: UBERON:0004590 ! sphincter muscle intersection_of: BFO:0000050 UBERON:0000057 ! part of urethra [Term] id: UBERON:0004921 name: subdivision of digestive tract def: "A proximal-distal subdivision of the digestive tract." [http://orcid.org/0000-0002-6601-2165] subset: human_reference_atlas subset: non_informative synonym: "alimentary system subdivision" RELATED [FMA:71131] synonym: "gut section" RELATED [FBbt:00100315] synonym: "intestinal tract" RELATED [] synonym: "segment of intestinal tract" RELATED [] synonym: "subdivision of alimentary system" RELATED [FMA:71131] xref: FBbt:00100315 {sssom:mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"} xref: FMA:71131 is_a: UBERON:0013522 ! subdivision of tube intersection_of: UBERON:0013522 ! subdivision of tube intersection_of: subdivision_of UBERON:0001555 ! digestive tract relationship: BFO:0000050 UBERON:0001555 ! part of digestive tract relationship: subdivision_of UBERON:0001555 ! digestive tract property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "subdivision of digestive tract" xsd:string [Term] id: UBERON:0004923 name: organ component layer def: "A part of a wall of an organ that forms a layer." [http://orcid.org/0000-0002-6601-2165] subset: human_reference_atlas subset: upper_level xref: FMA:82485 is_a: UBERON:0000064 ! organ part relationship: BFO:0000050 UBERON:0000060 ! part of anatomical wall property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "organ component layer" xsd:string [Term] id: UBERON:0004924 name: submucosa of pharynx def: "The tissue underlying the tunica mucosa of the pharynx." [BTO:0002113] synonym: "pharyngeal submucosa" EXACT [FMA:75144] synonym: "pharyngobasilar fascia" RELATED [] synonym: "pharynx submucosa" EXACT [OBOL:automatic] synonym: "submucous coat of pharynx" RELATED [BTO:0002113] synonym: "submucous layer of pharynx" RELATED [BTO:0002113] synonym: "tela submucosa pharyngea" EXACT OMO:0003011 [FMA:75144, FMA:TA] synonym: "tela submucosa pharyngis" EXACT OMO:0003011 [BTO:0002113] xref: BTO:0002113 xref: FMA:75144 xref: SCTID:19594009 is_a: UBERON:0004777 ! respiratory system submucosa is_a: UBERON:0018257 ! submucosa of digestive tract intersection_of: UBERON:0000009 ! submucosa intersection_of: BFO:0000050 UBERON:0001042 ! part of chordate pharynx relationship: BFO:0000050 UBERON:0001042 ! part of chordate pharynx property_value: skos:prefLabel "submucosa of pharynx" xsd:string [Term] id: UBERON:0004926 name: submucosa of cystic duct def: "A submucosa that is part of a cystic duct [Automatically generated definition]." [OBOL:automatic] synonym: "cystic duct submucosa" EXACT [OBOL:automatic] synonym: "cystic ductal submucosa" EXACT [FMA:18013] xref: FMA:18013 is_a: UBERON:0004938 ! submucosa of biliary tree intersection_of: UBERON:0000009 ! submucosa intersection_of: BFO:0000050 UBERON:0001152 ! part of cystic duct relationship: BFO:0000050 UBERON:0001152 ! part of cystic duct property_value: skos:prefLabel "submucosa of cystic duct" xsd:string [Term] id: UBERON:0004927 name: submucosa of cecum def: "A submucosa that is part of a cecum [Automatically generated definition]." [OBOL:automatic] subset: human_reference_atlas synonym: "caecum submucosa" EXACT [OBOL:automatic] synonym: "cecum submucosa" EXACT [OBOL:automatic] synonym: "intestinum crassum caecum submucosa" EXACT [OBOL:automatic] synonym: "submucosa of caecum" EXACT [OBOL:automatic] synonym: "submucosa of intestinum crassum caecum" EXACT [OBOL:automatic] xref: FMA:14999 is_a: UBERON:0003331 ! submucosa of colon intersection_of: UBERON:0000009 ! submucosa intersection_of: BFO:0000050 UBERON:0001153 ! part of caecum relationship: BFO:0000050 UBERON:0001153 ! part of caecum property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0004928 name: submucosa of appendix def: "A submucosa that is part of an appendix [Automatically generated definition]." [OBOL:automatic] subset: human_reference_atlas synonym: "appendiceal submucosa" EXACT [FMA:14992] synonym: "appendix submucosa" EXACT [OBOL:automatic] synonym: "caecal appendix submucosa" EXACT [OBOL:automatic] synonym: "submucosa of caecal appendix" EXACT [OBOL:automatic] synonym: "submucosa of vermiform appendix" EXACT [OBOL:automatic] synonym: "submucosa of vermix" EXACT [OBOL:automatic] synonym: "vermiform appendix submucosa" EXACT [OBOL:automatic] synonym: "vermix submucosa" EXACT [OBOL:automatic] xref: FMA:14992 xref: SCTID:86833001 is_a: UBERON:0001208 ! submucosa of large intestine intersection_of: UBERON:0000009 ! submucosa intersection_of: BFO:0000050 UBERON:0001154 ! part of vermiform appendix relationship: BFO:0000050 UBERON:0001154 ! part of vermiform appendix property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0004929 name: submucosa of ascending colon def: "A submucosa that is part of an ascending colon [Automatically generated definition]." [OBOL:automatic] synonym: "ascending colon submucosa" EXACT [OBOL:automatic] xref: FMA:15006 is_a: UBERON:0003331 ! submucosa of colon intersection_of: UBERON:0000009 ! submucosa intersection_of: BFO:0000050 UBERON:0001156 ! part of ascending colon relationship: BFO:0000050 UBERON:0001156 ! part of ascending colon [Term] id: UBERON:0004930 name: submucosa of transverse colon def: "A submucosa that is part of a transverse colon [Automatically generated definition]." [OBOL:automatic] synonym: "transverse colon submucosa" EXACT [OBOL:automatic] xref: FMA:15013 is_a: UBERON:0003331 ! submucosa of colon intersection_of: UBERON:0000009 ! submucosa intersection_of: BFO:0000050 UBERON:0001157 ! part of transverse colon relationship: BFO:0000050 UBERON:0001157 ! part of transverse colon [Term] id: UBERON:0004931 name: submucosa of descending colon def: "A submucosa that is part of a descending colon [Automatically generated definition]." [OBOL:automatic] synonym: "descending colon submucosa" EXACT [OBOL:automatic] xref: FMA:15020 is_a: UBERON:0003331 ! submucosa of colon intersection_of: UBERON:0000009 ! submucosa intersection_of: BFO:0000050 UBERON:0001158 ! part of descending colon relationship: BFO:0000050 UBERON:0001158 ! part of descending colon [Term] id: UBERON:0004932 name: submucosa of sigmoid colon def: "A submucosa that is part of a sigmoid colon [Automatically generated definition]." [OBOL:automatic] synonym: "sigmoid colon submucosa" EXACT [OBOL:automatic] xref: FMA:15027 is_a: UBERON:0003331 ! submucosa of colon intersection_of: UBERON:0000009 ! submucosa intersection_of: BFO:0000050 UBERON:0001159 ! part of sigmoid colon relationship: BFO:0000050 UBERON:0001159 ! part of sigmoid colon property_value: skos:prefLabel "submucosa of sigmoid colon" xsd:string [Term] id: UBERON:0004933 name: submucosa of fundus of stomach def: "A submucosa that is part of a fundus of stomach [Automatically generated definition]." [OBOL:automatic] synonym: "fundus gastricus (ventricularis) submucosa" EXACT [OBOL:automatic] synonym: "fundus of stomach submucosa" EXACT [OBOL:automatic] synonym: "stomach fundus submucosa" EXACT [OBOL:automatic] synonym: "submucosa of fundus gastricus (ventricularis)" EXACT [OBOL:automatic] synonym: "submucosa of stomach fundus" EXACT [OBOL:automatic] xref: EMAPA:27153 xref: FMA:17058 is_a: UBERON:0001200 ! submucosa of stomach intersection_of: UBERON:0000009 ! submucosa intersection_of: BFO:0000050 UBERON:0001160 ! part of fundus of stomach relationship: BFO:0000050 UBERON:0001160 ! part of fundus of stomach [Term] id: UBERON:0004934 name: submucosa of body of stomach def: "A submucosa that is part of a body of stomach [Automatically generated definition]." [OBOL:automatic] synonym: "body of stomach submucosa" EXACT [OBOL:automatic] synonym: "corpus gastricum (ventriculare) submucosa" EXACT [OBOL:automatic] synonym: "gastric body submucosa" EXACT [OBOL:automatic] synonym: "stomach body submucosa" EXACT [OBOL:automatic] synonym: "submucosa of corpus gastricum (ventriculare)" EXACT [OBOL:automatic] synonym: "submucosa of gastric body" EXACT [OBOL:automatic] synonym: "submucosa of stomach body" EXACT [OBOL:automatic] xref: FMA:17059 is_a: UBERON:0001200 ! submucosa of stomach intersection_of: UBERON:0000009 ! submucosa intersection_of: BFO:0000050 UBERON:0001161 ! part of body of stomach relationship: BFO:0000050 UBERON:0001161 ! part of body of stomach property_value: skos:prefLabel "submucosa of body of stomach" xsd:string [Term] id: UBERON:0004935 name: submucosa of cardia of stomach def: "A submucosa that is part of a cardia of stomach [Automatically generated definition]." [OBOL:automatic] synonym: "cardia of stomach submucosa" EXACT [OBOL:automatic] synonym: "cardial part of stomach submucosa" EXACT [OBOL:automatic] synonym: "gastric cardia submucosa" EXACT [OBOL:automatic] synonym: "pars cardiaca (gaster) submucosa" EXACT [OBOL:automatic] synonym: "stomach cardiac region submucosa" EXACT [OBOL:automatic] synonym: "submucosa of cardial part of stomach" EXACT [OBOL:automatic] synonym: "submucosa of gastric cardia" EXACT [OBOL:automatic] synonym: "submucosa of pars cardiaca (gaster)" EXACT [OBOL:automatic] synonym: "submucosa of stomach cardiac region" EXACT [OBOL:automatic] xref: FMA:17457 is_a: UBERON:0001200 ! submucosa of stomach intersection_of: UBERON:0000009 ! submucosa intersection_of: BFO:0000050 UBERON:0001162 ! part of cardia of stomach relationship: BFO:0000050 UBERON:0001162 ! part of cardia of stomach [Term] id: UBERON:0004936 name: submucosa of pyloric antrum def: "A submucosa that is part of a pyloric antrum [Automatically generated definition]." [OBOL:automatic] synonym: "antrum of stomach submucosa" EXACT [OBOL:automatic] synonym: "pyloric antrum submucosa" EXACT [OBOL:automatic] synonym: "stomach pyloric antrum submucosa" EXACT [OBOL:automatic] synonym: "submucosa of antrum of stomach" EXACT [OBOL:automatic] synonym: "submucosa of stomach pyloric antrum" EXACT [OBOL:automatic] xref: FMA:17060 is_a: UBERON:0004937 ! submucosa of pylorus intersection_of: UBERON:0000009 ! submucosa intersection_of: BFO:0000050 UBERON:0001165 ! part of pyloric antrum relationship: BFO:0000050 UBERON:0001165 ! part of pyloric antrum property_value: skos:prefLabel "submucosa of pyloric antrum" xsd:string [Term] id: UBERON:0004937 name: submucosa of pylorus def: "A submucosa that is part of a pylorus [Automatically generated definition]." [OBOL:automatic] synonym: "pyloric part of stomach submucosa" EXACT [OBOL:automatic] synonym: "pyloric submucosa" EXACT [] synonym: "pylorus submucosa" EXACT [FMA:17462, OBOL:automatic] synonym: "stomach pyloric region submucosa" EXACT [OBOL:automatic] synonym: "submucosa of pyloric part of stomach" EXACT [OBOL:automatic] synonym: "submucosa of stomach pyloric region" EXACT [OBOL:automatic] xref: EMAPA:27201 xref: FMA:17462 is_a: UBERON:0001200 ! submucosa of stomach intersection_of: UBERON:0000009 ! submucosa intersection_of: BFO:0000050 UBERON:0001166 ! part of pylorus relationship: BFO:0000050 UBERON:0001166 ! part of pylorus property_value: skos:prefLabel "submucosa of pylorus" xsd:string [Term] id: UBERON:0004938 name: submucosa of biliary tree def: "A submucosa that is part of a biliary tree [Automatically generated definition]." [OBOL:automatic] synonym: "biliary tract submucosa" EXACT [OBOL:automatic] synonym: "biliary tree submucosa" EXACT [OBOL:automatic] synonym: "submucosa of biliary tract" EXACT [OBOL:automatic] xref: FMA:18009 is_a: UBERON:0000009 ! submucosa intersection_of: UBERON:0000009 ! submucosa intersection_of: BFO:0000050 UBERON:0001173 ! part of biliary tree relationship: BFO:0000050 UBERON:0001173 ! part of biliary tree property_value: skos:prefLabel "submucosa of biliary tree" xsd:string [Term] id: UBERON:0004939 name: submucosa of common bile duct def: "A submucosa that is part of a common bile duct [Automatically generated definition]." [OBOL:automatic] synonym: "common bile duct submucosa" EXACT [OBOL:automatic] synonym: "common bile ductal submucosa" EXACT [FMA:18011] synonym: "ductus choledochus (biliaris) submucosa" EXACT [OBOL:automatic] synonym: "submucosa of ductus choledochus (biliaris)" EXACT [OBOL:automatic] xref: FMA:18011 is_a: UBERON:0004938 ! submucosa of biliary tree intersection_of: UBERON:0000009 ! submucosa intersection_of: BFO:0000050 UBERON:0001174 ! part of common bile duct relationship: BFO:0000050 UBERON:0001174 ! part of common bile duct property_value: skos:prefLabel "submucosa of common bile duct" xsd:string [Term] id: UBERON:0004940 name: submucosa of common hepatic duct def: "A submucosa that is part of a common hepatic duct [Automatically generated definition]." [OBOL:automatic] synonym: "common hepatic duct submucosa" EXACT [OBOL:automatic] synonym: "common hepatic ductal submucosa" EXACT [FMA:18014] synonym: "hepatic duct submucosa" EXACT [OBOL:automatic] synonym: "submucosa of hepatic duct" EXACT [OBOL:automatic] xref: FMA:18014 is_a: UBERON:0004938 ! submucosa of biliary tree intersection_of: UBERON:0000009 ! submucosa intersection_of: BFO:0000050 UBERON:0001175 ! part of common hepatic duct relationship: BFO:0000050 UBERON:0001175 ! part of common hepatic duct property_value: skos:prefLabel "submucosa of common hepatic duct" xsd:string [Term] id: UBERON:0004941 name: submucosa of right hepatic duct def: "A submucosa that is part of a right hepatic duct [Automatically generated definition]." [OBOL:automatic] synonym: "right hepatic duct submucosa" EXACT [OBOL:automatic] synonym: "right hepatic ductal submucosa" EXACT [FMA:18015] xref: FMA:18015 is_a: UBERON:0004938 ! submucosa of biliary tree intersection_of: UBERON:0000009 ! submucosa intersection_of: BFO:0000050 UBERON:0001176 ! part of right hepatic duct relationship: BFO:0000050 UBERON:0001176 ! part of right hepatic duct property_value: skos:prefLabel "submucosa of right hepatic duct" xsd:string [Term] id: UBERON:0004942 name: submucosa of left hepatic duct def: "A submucosa that is part of a left hepatic duct [Automatically generated definition]." [OBOL:automatic] synonym: "left hepatic duct submucosa" EXACT [OBOL:automatic] synonym: "left hepatic ductal submucosa" EXACT [FMA:18017] xref: FMA:18017 is_a: UBERON:0004938 ! submucosa of biliary tree intersection_of: UBERON:0000009 ! submucosa intersection_of: BFO:0000050 UBERON:0001177 ! part of left hepatic duct relationship: BFO:0000050 UBERON:0001177 ! part of left hepatic duct property_value: skos:prefLabel "submucosa of left hepatic duct" xsd:string [Term] id: UBERON:0004943 name: submucosa of urinary bladder def: "The submucous layer of the wall of the urinary bladder." [BTO:0002117] subset: human_reference_atlas synonym: "bladder submucosa" EXACT [OBOL:automatic] synonym: "submucosa of bladder" EXACT [OBOL:automatic] synonym: "submucous layer of urinary bladder" RELATED [BTO:0002117] synonym: "tela submucosa (vesica urinaria)" EXACT OMO:0003011 [FMA:15929, FMA:TA] synonym: "tela submucosa vesicae" EXACT OMO:0003011 [FMA:15929, FMA:TA] synonym: "tela submucosa vesicae urinariae" EXACT [BTO:0002117] synonym: "urinary bladder submucosa" EXACT [OBOL:automatic] xref: BTO:0002117 xref: EMAPA:32275 xref: FMA:15929 xref: SCTID:88384001 is_a: UBERON:0000009 ! submucosa intersection_of: UBERON:0000009 ! submucosa intersection_of: BFO:0000050 UBERON:0001255 ! part of urinary bladder relationship: BFO:0000050 UBERON:0001256 {source="https://github.com/obophenotype/uberon/wiki/Inferring-part-of-relationships"} ! part of wall of urinary bladder property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0004944 name: submucosa of trigone of urinary bladder def: "A submucosa that is part of a trigone of urinary bladder [Automatically generated definition]." [OBOL:automatic] subset: human_reference_atlas synonym: "deep trigone submucosa" EXACT [OBOL:automatic] synonym: "Lieutaud ' s trigone submucosa" EXACT [OBOL:automatic] synonym: "submucosa of deep trigone" EXACT [OBOL:automatic] synonym: "submucosa of Lieutaud ' s trigone" EXACT [OBOL:automatic] synonym: "submucosa of trigone of bladder" EXACT [OBOL:automatic] synonym: "submucosa of urinary bladder trigone" EXACT [OBOL:automatic] synonym: "submucosa of vesical trigone" EXACT [OBOL:automatic] synonym: "trigone of bladder submucosa" EXACT [OBOL:automatic] synonym: "trigone of urinary bladder submucosa" EXACT [OBOL:automatic] synonym: "urinary bladder trigone submucosa" EXACT [OBOL:automatic] synonym: "vesical trigone submucosa" EXACT [OBOL:automatic] xref: EMAPA:32304 xref: FMA:17852 is_a: UBERON:0004943 ! submucosa of urinary bladder intersection_of: UBERON:0000009 ! submucosa intersection_of: BFO:0000050 UBERON:0001257 ! part of trigone of urinary bladder relationship: BFO:0000050 UBERON:0001257 ! part of trigone of urinary bladder property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0004945 name: submucosa of neck of urinary bladder def: "A submucosa that is part of a neck of urinary bladder [Automatically generated definition]." [OBOL:automatic] synonym: "bladder neck submucosa" EXACT [OBOL:automatic] synonym: "neck of bladder submucosa" EXACT [OBOL:automatic] synonym: "neck of urinary bladder submucosa" EXACT [OBOL:automatic] synonym: "submucosa of bladder neck" EXACT [OBOL:automatic] synonym: "submucosa of neck of bladder" EXACT [OBOL:automatic] synonym: "submucosa of urinary bladder neck" EXACT [OBOL:automatic] synonym: "submucosa of vesical neck" EXACT [OBOL:automatic] synonym: "urinary bladder neck submucosa" EXACT [OBOL:automatic] synonym: "vesical neck submucosa" EXACT [OBOL:automatic] xref: EMAPA:32276 xref: FMA:17851 is_a: UBERON:0004943 ! submucosa of urinary bladder intersection_of: UBERON:0000009 ! submucosa intersection_of: BFO:0000050 UBERON:0001258 ! part of neck of urinary bladder relationship: BFO:0000050 UBERON:0001258 ! part of neck of urinary bladder [Term] id: UBERON:0004946 name: submucosa of ileum def: "A submucosa that is part of a ileum [Automatically generated definition]." [OBOL:automatic] subset: human_reference_atlas synonym: "ileal submucosa" EXACT [FMA:14957] synonym: "ileum submucosa" EXACT [OBOL:automatic] xref: FMA:14957 xref: SCTID:65374006 is_a: UBERON:0001205 ! submucosa of small intestine intersection_of: UBERON:0000009 ! submucosa intersection_of: BFO:0000050 UBERON:0002116 ! part of ileum relationship: BFO:0000050 UBERON:0002116 ! part of ileum property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0004950 name: submucosa of lobar bronchus def: "A submucosa that is part of a lobar bronchus [Automatically generated definition]." [OBOL:automatic] synonym: "lobar bronchial submucosa" EXACT [FMA:62669] synonym: "lobar bronchus submucosa" EXACT [OBOL:automatic] synonym: "secondary bronchus submucosa" EXACT [OBOL:automatic] synonym: "submucosa of secondary bronchus" EXACT [OBOL:automatic] xref: FMA:62669 is_a: UBERON:0001957 ! submucosa of bronchus intersection_of: UBERON:0000009 ! submucosa intersection_of: BFO:0000050 UBERON:0002183 ! part of lobar bronchus relationship: BFO:0000050 UBERON:0002183 ! part of lobar bronchus [Term] id: UBERON:0004951 name: submucosa of segmental bronchus def: "A submucosa that is part of a segmental bronchus [Automatically generated definition]." [OBOL:automatic] synonym: "segmental bronchial submucosa" EXACT [FMA:62670] synonym: "segmental bronchus submucosa" EXACT [OBOL:automatic] synonym: "submucosa of tertiary bronchus" EXACT [OBOL:automatic] synonym: "tertiary bronchus submucosa" EXACT [OBOL:automatic] xref: FMA:62670 is_a: UBERON:0001957 ! submucosa of bronchus intersection_of: UBERON:0000009 ! submucosa intersection_of: BFO:0000050 UBERON:0002184 ! part of segmental bronchus relationship: BFO:0000050 UBERON:0002184 ! part of segmental bronchus [Term] id: UBERON:0004952 name: submucosa of bronchiole def: "A submucosa that is part of a bronchiole [Automatically generated definition]." [OBOL:automatic] synonym: "bronchiole submucosa" EXACT [OBOL:automatic] xref: FMA:62775 is_a: UBERON:0004777 ! respiratory system submucosa intersection_of: UBERON:0000009 ! submucosa intersection_of: BFO:0000050 UBERON:0002186 ! part of bronchiole relationship: BFO:0000050 UBERON:0002186 ! part of bronchiole [Term] id: UBERON:0004980 name: mucosa of ureter def: "A mucosa that is part of a ureter [Automatically generated definition]." [OBOL:automatic] synonym: "mucosa of organ of ureter" EXACT [OBOL:automatic] synonym: "mucosal layer of ureter" EXACT [FMA:15894] synonym: "mucous membrane of ureter" EXACT [OBOL:automatic] synonym: "organ mucosa of ureter" EXACT [OBOL:automatic] synonym: "tunica mucosa (ureter)" EXACT [FMA:15894] synonym: "tunica mucosa ureteris" EXACT OMO:0003011 [FMA:15894, FMA:TA] synonym: "ureter mucosa" EXACT [OBOL:automatic] synonym: "ureter mucosa of organ" EXACT [OBOL:automatic] synonym: "ureter mucous membrane" EXACT [OBOL:automatic] synonym: "ureter organ mucosa" EXACT [OBOL:automatic] synonym: "ureteral mucosa" EXACT [FMA:15894] synonym: "ureteric mucosa" EXACT [FMA:15894] xref: FMA:15894 xref: galen:MucousMembraneOfUreter xref: SCTID:40476001 is_a: UBERON:0000344 ! mucosa intersection_of: UBERON:0000344 ! mucosa intersection_of: BFO:0000050 UBERON:0000056 ! part of ureter relationship: BFO:0000050 UBERON:0009916 {source="https://github.com/obophenotype/uberon/wiki/Inferring-part-of-relationships"} ! part of wall of ureter [Term] id: UBERON:0004983 name: mucosa of vagina def: "A mucosa that is part of a vagina [Automatically generated definition]." [OBOL:automatic] synonym: "mucosa of organ of vagina" EXACT [OBOL:automatic] synonym: "mucous membrane of vagina" EXACT [OBOL:automatic] synonym: "organ mucosa of vagina" EXACT [OBOL:automatic] synonym: "tunica mucosa vaginae" EXACT OMO:0003011 [FMA:19975, FMA:TA] synonym: "vagina mucosa" EXACT [OBOL:automatic] synonym: "vagina mucosa of organ" EXACT [OBOL:automatic] synonym: "vagina mucous membrane" EXACT [OBOL:automatic] synonym: "vagina organ mucosa" EXACT [OBOL:automatic] synonym: "vaginal mucosa" EXACT [FMA:19975] xref: BTO:0005676 xref: FMA:19975 xref: SCTID:362245006 is_a: UBERON:0019042 ! reproductive system mucosa intersection_of: UBERON:0000344 ! mucosa intersection_of: BFO:0000050 UBERON:0000996 ! part of vagina relationship: BFO:0000050 UBERON:0000996 ! part of vagina [Term] id: UBERON:0004984 name: mucosa of seminal vesicle def: "A mucosa that is part of a seminal vesicle [Automatically generated definition]." [OBOL:automatic] synonym: "mucosa of organ of seminal gland" EXACT [OBOL:automatic] synonym: "mucosa of organ of seminal vesicle" EXACT [OBOL:automatic] synonym: "mucosa of seminal gland" EXACT [OBOL:automatic] synonym: "mucous membrane of seminal gland" EXACT [OBOL:automatic] synonym: "mucous membrane of seminal vesicle" EXACT [OBOL:automatic] synonym: "organ mucosa of seminal gland" EXACT [OBOL:automatic] synonym: "organ mucosa of seminal vesicle" EXACT [OBOL:automatic] synonym: "seminal gland mucosa" EXACT [OBOL:automatic] synonym: "seminal gland mucosa of organ" EXACT [OBOL:automatic] synonym: "seminal gland mucous membrane" EXACT [OBOL:automatic] synonym: "seminal gland organ mucosa" EXACT [OBOL:automatic] synonym: "seminal vesicle mucosa" EXACT [OBOL:automatic] synonym: "seminal vesicle mucosa of organ" EXACT [OBOL:automatic] synonym: "seminal vesicle mucous membrane" EXACT [OBOL:automatic] synonym: "seminal vesicle organ mucosa" EXACT [OBOL:automatic] synonym: "tunica mucosa glandulae vesiculosae" EXACT OMO:0003011 [FMA:19405, FMA:TA] xref: FMA:19405 xref: SCTID:252260007 is_a: UBERON:0019042 ! reproductive system mucosa intersection_of: UBERON:0000344 ! mucosa intersection_of: BFO:0000050 UBERON:0000998 ! part of seminal vesicle relationship: BFO:0000050 UBERON:0000998 ! part of seminal vesicle [Term] id: UBERON:0004985 name: mucosa of ejaculatory duct def: "A mucosa that is part of a ejaculatory duct [Automatically generated definition]." [OBOL:automatic] synonym: "ejaculatory duct mucosa" EXACT [OBOL:automatic] synonym: "ejaculatory duct mucosa of organ" EXACT [OBOL:automatic] synonym: "ejaculatory duct mucous membrane" EXACT [OBOL:automatic] synonym: "ejaculatory duct organ mucosa" EXACT [OBOL:automatic] synonym: "ejaculatory ductal mucosa" EXACT [FMA:19373] synonym: "mucosa of organ of ejaculatory duct" EXACT [OBOL:automatic] synonym: "mucous membrane of ejaculatory duct" EXACT [OBOL:automatic] synonym: "organ mucosa of ejaculatory duct" EXACT [OBOL:automatic] xref: FMA:19373 is_a: UBERON:0019042 ! reproductive system mucosa intersection_of: UBERON:0000344 ! mucosa intersection_of: BFO:0000050 UBERON:0000999 ! part of ejaculatory duct relationship: BFO:0000050 UBERON:0000999 ! part of ejaculatory duct [Term] id: UBERON:0004986 name: mucosa of deferent duct def: "A mucosa that is part of a vas deferens [Automatically generated definition]." [OBOL:automatic] synonym: "deferent duct mucosa" EXACT [OBOL:automatic] synonym: "deferent duct mucosa of organ" EXACT [OBOL:automatic] synonym: "deferent duct mucous membrane" EXACT [OBOL:automatic] synonym: "deferent duct organ mucosa" EXACT [OBOL:automatic] synonym: "deferent ductal mucosa" EXACT [FMA:19240] synonym: "ductus deferens mucosa" EXACT [OBOL:automatic] synonym: "ductus deferens mucosa of organ" EXACT [OBOL:automatic] synonym: "ductus deferens mucous membrane" EXACT [OBOL:automatic] synonym: "ductus deferens organ mucosa" EXACT [OBOL:automatic] synonym: "mucosa of ductus deferens" EXACT [OBOL:automatic] synonym: "mucosa of organ of deferent duct" EXACT [OBOL:automatic] synonym: "mucosa of organ of ductus deferens" EXACT [OBOL:automatic] synonym: "mucosa of organ of sperm duct" EXACT [OBOL:automatic] synonym: "mucosa of organ of vas deferen" EXACT [OBOL:automatic] synonym: "mucosa of organ of vas deferens" EXACT [OBOL:automatic] synonym: "mucosa of sperm duct" EXACT [OBOL:automatic] synonym: "mucosa of vas deferen" EXACT [OBOL:automatic] synonym: "mucosa of vas deferens" EXACT [OBOL:automatic] synonym: "mucous membrane of deferent duct" EXACT [OBOL:automatic] synonym: "mucous membrane of ductus deferens" EXACT [OBOL:automatic] synonym: "mucous membrane of sperm duct" EXACT [OBOL:automatic] synonym: "mucous membrane of vas deferen" EXACT [OBOL:automatic] synonym: "mucous membrane of vas deferens" EXACT [OBOL:automatic] synonym: "organ mucosa of deferent duct" EXACT [OBOL:automatic] synonym: "organ mucosa of ductus deferens" EXACT [OBOL:automatic] synonym: "organ mucosa of sperm duct" EXACT [OBOL:automatic] synonym: "organ mucosa of vas deferen" EXACT [OBOL:automatic] synonym: "organ mucosa of vas deferens" EXACT [OBOL:automatic] synonym: "sperm duct mucosa" EXACT [OBOL:automatic] synonym: "sperm duct mucosa of organ" EXACT [OBOL:automatic] synonym: "sperm duct mucous membrane" EXACT [OBOL:automatic] synonym: "sperm duct organ mucosa" EXACT [OBOL:automatic] synonym: "tunica mucosa (ductus deferens)" EXACT [FMA:19240] synonym: "tunica mucosa ductus deferentis" EXACT OMO:0003011 [FMA:19240, FMA:TA] synonym: "vas deferen mucosa" EXACT [OBOL:automatic] synonym: "vas deferen mucosa of organ" EXACT [OBOL:automatic] synonym: "vas deferen mucous membrane" EXACT [OBOL:automatic] synonym: "vas deferen organ mucosa" EXACT [OBOL:automatic] synonym: "vas deferens mucosa" EXACT [OBOL:automatic] synonym: "vas deferens mucosa of organ" EXACT [OBOL:automatic] synonym: "vas deferens mucous membrane" EXACT [OBOL:automatic] synonym: "vas deferens organ mucosa" EXACT [OBOL:automatic] xref: FMA:19240 xref: SCTID:299626000 is_a: UBERON:0019042 ! reproductive system mucosa intersection_of: UBERON:0000344 ! mucosa intersection_of: BFO:0000050 UBERON:0001000 ! part of vas deferens relationship: BFO:0000050 UBERON:0001000 ! part of vas deferens [Term] id: UBERON:0004988 name: mucosa of cystic duct def: "A mucosa that is part of a cystic duct [Automatically generated definition]." [OBOL:automatic] synonym: "cystic duct mucosa" EXACT [OBOL:automatic] synonym: "cystic duct mucosa of organ" EXACT [OBOL:automatic] synonym: "cystic duct mucous membrane" EXACT [OBOL:automatic] synonym: "cystic duct organ mucosa" EXACT [OBOL:automatic] synonym: "cystic ductal mucosa" EXACT [FMA:14690] synonym: "mucosa of organ of cystic duct" EXACT [OBOL:automatic] synonym: "mucous membrane of cystic duct" EXACT [OBOL:automatic] synonym: "organ mucosa of cystic duct" EXACT [OBOL:automatic] xref: FMA:14690 is_a: UBERON:0004999 ! mucosa of biliary tree intersection_of: UBERON:0000344 ! mucosa intersection_of: BFO:0000050 UBERON:0001152 ! part of cystic duct relationship: BFO:0000050 UBERON:0001152 ! part of cystic duct property_value: skos:prefLabel "mucosa of cystic duct" xsd:string [Term] id: UBERON:0004989 name: mucosa of appendix def: "A mucosa that is part of an appendix [Automatically generated definition]." [OBOL:automatic] subset: human_reference_atlas synonym: "appendiceal mucous membrane" EXACT [FMA:14991] synonym: "appendix mucosa" EXACT [OBOL:automatic] synonym: "appendix mucosa of organ" EXACT [OBOL:automatic] synonym: "appendix mucous membrane" EXACT [OBOL:automatic] synonym: "appendix organ mucosa" EXACT [OBOL:automatic] synonym: "caecal appendix mucosa" EXACT [OBOL:automatic] synonym: "caecal appendix mucosa of organ" EXACT [OBOL:automatic] synonym: "caecal appendix mucous membrane" EXACT [OBOL:automatic] synonym: "caecal appendix organ mucosa" EXACT [OBOL:automatic] synonym: "mucosa of caecal appendix" EXACT [OBOL:automatic] synonym: "mucosa of organ of appendix" EXACT [OBOL:automatic] synonym: "mucosa of organ of caecal appendix" EXACT [OBOL:automatic] synonym: "mucosa of organ of vermiform appendix" EXACT [OBOL:automatic] synonym: "mucosa of organ of vermix" EXACT [OBOL:automatic] synonym: "mucosa of vermiform appendix" EXACT [OBOL:automatic] synonym: "mucosa of vermix" EXACT [OBOL:automatic] synonym: "mucous membrane of appendix" EXACT [OBOL:automatic] synonym: "mucous membrane of caecal appendix" EXACT [OBOL:automatic] synonym: "mucous membrane of vermiform appendix" EXACT [OBOL:automatic] synonym: "mucous membrane of vermix" EXACT [OBOL:automatic] synonym: "organ mucosa of appendix" EXACT [OBOL:automatic] synonym: "organ mucosa of caecal appendix" EXACT [OBOL:automatic] synonym: "organ mucosa of vermiform appendix" EXACT [OBOL:automatic] synonym: "organ mucosa of vermix" EXACT [OBOL:automatic] synonym: "vermiform appendix mucosa" EXACT [OBOL:automatic] synonym: "vermiform appendix mucosa of organ" EXACT [OBOL:automatic] synonym: "vermiform appendix mucous membrane" EXACT [OBOL:automatic] synonym: "vermiform appendix organ mucosa" EXACT [OBOL:automatic] synonym: "vermix mucosa" EXACT [OBOL:automatic] synonym: "vermix mucosa of organ" EXACT [OBOL:automatic] synonym: "vermix mucous membrane" EXACT [OBOL:automatic] synonym: "vermix organ mucosa" EXACT [OBOL:automatic] xref: CALOHA:TS-2022 xref: FMA:14991 xref: SCTID:362155000 is_a: UBERON:0001207 ! mucosa of large intestine intersection_of: UBERON:0000344 ! mucosa intersection_of: BFO:0000050 UBERON:0001154 ! part of vermiform appendix relationship: BFO:0000050 UBERON:0001154 ! part of vermiform appendix property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0004990 name: mucosa of ascending colon def: "A mucosa that is part of an ascending colon [Automatically generated definition]." [OBOL:automatic] subset: human_reference_atlas synonym: "ascending colon mucosa" EXACT [OBOL:automatic] synonym: "ascending colon mucosa of organ" EXACT [OBOL:automatic] synonym: "ascending colon mucous membrane" EXACT [OBOL:automatic] synonym: "ascending colon organ mucosa" EXACT [OBOL:automatic] synonym: "mucosa of organ of ascending colon" EXACT [OBOL:automatic] synonym: "mucous membrane of ascending colon" EXACT [OBOL:automatic] synonym: "organ mucosa of ascending colon" EXACT [OBOL:automatic] xref: FMA:15005 is_a: UBERON:0000317 ! colonic mucosa intersection_of: UBERON:0000344 ! mucosa intersection_of: BFO:0000050 UBERON:0001156 ! part of ascending colon relationship: BFO:0000050 UBERON:0001156 ! part of ascending colon property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0004991 name: mucosa of transverse colon def: "A mucosa that is part of a transverse colon [Automatically generated definition]." [OBOL:automatic] subset: human_reference_atlas synonym: "mucosa of organ of transverse colon" EXACT [OBOL:automatic] synonym: "mucous membrane of transverse colon" EXACT [OBOL:automatic] synonym: "organ mucosa of transverse colon" EXACT [OBOL:automatic] synonym: "transverse colon mucosa" EXACT [OBOL:automatic] synonym: "transverse colon mucosa of organ" EXACT [OBOL:automatic] synonym: "transverse colon mucous membrane" EXACT [OBOL:automatic] synonym: "transverse colon organ mucosa" EXACT [OBOL:automatic] xref: FMA:15012 is_a: UBERON:0000317 ! colonic mucosa intersection_of: UBERON:0000344 ! mucosa intersection_of: BFO:0000050 UBERON:0001157 ! part of transverse colon relationship: BFO:0000050 UBERON:0001157 ! part of transverse colon property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0004992 name: mucosa of descending colon def: "A mucosa that is part of a descending colon [Automatically generated definition]." [OBOL:automatic] subset: human_reference_atlas synonym: "descending colon mucosa" EXACT [OBOL:automatic] synonym: "descending colon mucosa of organ" EXACT [OBOL:automatic] synonym: "descending colon mucous membrane" EXACT [OBOL:automatic] synonym: "descending colon organ mucosa" EXACT [OBOL:automatic] synonym: "mucosa of organ of descending colon" EXACT [OBOL:automatic] synonym: "mucous membrane of descending colon" EXACT [OBOL:automatic] synonym: "organ mucosa of descending colon" EXACT [OBOL:automatic] xref: FMA:15019 is_a: UBERON:0000317 ! colonic mucosa intersection_of: UBERON:0000344 ! mucosa intersection_of: BFO:0000050 UBERON:0001158 ! part of descending colon relationship: BFO:0000050 UBERON:0001158 ! part of descending colon property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0004993 name: mucosa of sigmoid colon def: "A mucosa that is part of a sigmoid colon [Automatically generated definition]." [OBOL:automatic] subset: human_reference_atlas synonym: "mucosa of organ of sigmoid colon" EXACT [OBOL:automatic] synonym: "mucous membrane of sigmoid colon" EXACT [OBOL:automatic] synonym: "organ mucosa of sigmoid colon" EXACT [OBOL:automatic] synonym: "sigmoid colon mucosa" EXACT [OBOL:automatic] synonym: "sigmoid colon mucosa of organ" EXACT [OBOL:automatic] synonym: "sigmoid colon mucous membrane" EXACT [OBOL:automatic] synonym: "sigmoid colon organ mucosa" EXACT [OBOL:automatic] xref: FMA:15026 is_a: UBERON:0000317 ! colonic mucosa intersection_of: UBERON:0000344 ! mucosa intersection_of: BFO:0000050 UBERON:0001159 ! part of sigmoid colon relationship: BFO:0000050 UBERON:0001159 ! part of sigmoid colon property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "mucosa of sigmoid colon" xsd:string [Term] id: UBERON:0004994 name: mucosa of fundus of stomach def: "A mucosa that is part of a fundus of stomach [Automatically generated definition]." [OBOL:automatic] synonym: "fundus gastricus (ventricularis) mucosa" EXACT [OBOL:automatic] synonym: "fundus gastricus (ventricularis) mucosa of organ" EXACT [OBOL:automatic] synonym: "fundus gastricus (ventricularis) mucous membrane" EXACT [OBOL:automatic] synonym: "fundus gastricus (ventricularis) organ mucosa" EXACT [OBOL:automatic] synonym: "fundus of stomach mucosa" EXACT [OBOL:automatic] synonym: "fundus of stomach mucosa of organ" EXACT [OBOL:automatic] synonym: "fundus of stomach mucous membrane" EXACT [OBOL:automatic] synonym: "fundus of stomach organ mucosa" EXACT [OBOL:automatic] synonym: "mucosa of fundus gastricus (ventricularis)" EXACT [OBOL:automatic] synonym: "mucosa of organ of fundus gastricus (ventricularis)" EXACT [OBOL:automatic] synonym: "mucosa of organ of fundus of stomach" EXACT [OBOL:automatic] synonym: "mucosa of organ of stomach fundus" EXACT [OBOL:automatic] synonym: "mucosa of stomach fundus" EXACT [OBOL:automatic] synonym: "mucous membrane of fundus gastricus (ventricularis)" EXACT [OBOL:automatic] synonym: "mucous membrane of fundus of stomach" EXACT [OBOL:automatic] synonym: "mucous membrane of stomach fundus" EXACT [OBOL:automatic] synonym: "organ mucosa of fundus gastricus (ventricularis)" EXACT [OBOL:automatic] synonym: "organ mucosa of fundus of stomach" EXACT [OBOL:automatic] synonym: "organ mucosa of stomach fundus" EXACT [OBOL:automatic] synonym: "stomach fundus mucosa" EXACT [OBOL:automatic] synonym: "stomach fundus mucosa of organ" EXACT [OBOL:automatic] synonym: "stomach fundus mucous membrane" EXACT [OBOL:automatic] synonym: "stomach fundus organ mucosa" EXACT [OBOL:automatic] xref: EMAPA:27151 xref: FMA:17053 is_a: UBERON:0001199 ! mucosa of stomach intersection_of: UBERON:0000344 ! mucosa intersection_of: BFO:0000050 UBERON:0001160 ! part of fundus of stomach relationship: BFO:0000050 UBERON:0001160 ! part of fundus of stomach [Term] id: UBERON:0004995 name: mucosa of body of stomach def: "A mucosa that is part of a body of stomach [Automatically generated definition]." [OBOL:automatic] synonym: "body of stomach mucosa" EXACT [OBOL:automatic] synonym: "body of stomach mucosa of organ" EXACT [OBOL:automatic] synonym: "body of stomach mucous membrane" EXACT [OBOL:automatic] synonym: "body of stomach organ mucosa" EXACT [OBOL:automatic] synonym: "corpus gastricum (ventriculare) mucosa" EXACT [OBOL:automatic] synonym: "corpus gastricum (ventriculare) mucosa of organ" EXACT [OBOL:automatic] synonym: "corpus gastricum (ventriculare) mucous membrane" EXACT [OBOL:automatic] synonym: "corpus gastricum (ventriculare) organ mucosa" EXACT [OBOL:automatic] synonym: "gastric body mucosa" EXACT [OBOL:automatic] synonym: "gastric body mucosa of organ" EXACT [OBOL:automatic] synonym: "gastric body mucous membrane" EXACT [OBOL:automatic] synonym: "gastric body organ mucosa" EXACT [OBOL:automatic] synonym: "mucosa of corpus gastricum (ventriculare)" EXACT [OBOL:automatic] synonym: "mucosa of gastric body" EXACT [OBOL:automatic] synonym: "mucosa of organ of body of stomach" EXACT [OBOL:automatic] synonym: "mucosa of organ of corpus gastricum (ventriculare)" EXACT [OBOL:automatic] synonym: "mucosa of organ of gastric body" EXACT [OBOL:automatic] synonym: "mucosa of organ of stomach body" EXACT [OBOL:automatic] synonym: "mucosa of stomach body" EXACT [OBOL:automatic] synonym: "mucous membrane of body of stomach" EXACT [OBOL:automatic] synonym: "mucous membrane of corpus gastricum (ventriculare)" EXACT [OBOL:automatic] synonym: "mucous membrane of gastric body" EXACT [OBOL:automatic] synonym: "mucous membrane of stomach body" EXACT [OBOL:automatic] synonym: "organ mucosa of body of stomach" EXACT [OBOL:automatic] synonym: "organ mucosa of corpus gastricum (ventriculare)" EXACT [OBOL:automatic] synonym: "organ mucosa of gastric body" EXACT [OBOL:automatic] synonym: "organ mucosa of stomach body" EXACT [OBOL:automatic] synonym: "stomach body mucosa" EXACT [OBOL:automatic] synonym: "stomach body mucosa of organ" EXACT [OBOL:automatic] synonym: "stomach body mucous membrane" EXACT [OBOL:automatic] synonym: "stomach body organ mucosa" EXACT [OBOL:automatic] xref: FMA:17054 is_a: UBERON:0001199 ! mucosa of stomach intersection_of: UBERON:0000344 ! mucosa intersection_of: BFO:0000050 UBERON:0001161 ! part of body of stomach relationship: BFO:0000050 UBERON:0001161 ! part of body of stomach property_value: skos:prefLabel "mucosa of body of stomach" xsd:string [Term] id: UBERON:0004996 name: mucosa of cardia of stomach def: "A mucosa that is part of a cardia of stomach [Automatically generated definition]." [OBOL:automatic] synonym: "cardia of stomach mucosa" EXACT [OBOL:automatic] synonym: "cardia of stomach mucosa of organ" EXACT [OBOL:automatic] synonym: "cardia of stomach mucous membrane" EXACT [OBOL:automatic] synonym: "cardia of stomach organ mucosa" EXACT [OBOL:automatic] synonym: "cardial part of stomach mucosa" EXACT [OBOL:automatic] synonym: "cardial part of stomach mucosa of organ" EXACT [OBOL:automatic] synonym: "cardial part of stomach mucous membrane" EXACT [OBOL:automatic] synonym: "cardial part of stomach organ mucosa" EXACT [OBOL:automatic] synonym: "gastric cardia mucosa" EXACT [OBOL:automatic] synonym: "gastric cardia mucosa of organ" EXACT [OBOL:automatic] synonym: "gastric cardia mucous membrane" EXACT [OBOL:automatic] synonym: "gastric cardia organ mucosa" EXACT [OBOL:automatic] synonym: "mucosa of cardial part of stomach" EXACT [OBOL:automatic] synonym: "mucosa of gastric cardia" EXACT [OBOL:automatic] synonym: "mucosa of organ of cardia of stomach" EXACT [OBOL:automatic] synonym: "mucosa of organ of cardial part of stomach" EXACT [OBOL:automatic] synonym: "mucosa of organ of gastric cardia" EXACT [OBOL:automatic] synonym: "mucosa of organ of pars cardiaca (gaster)" EXACT [OBOL:automatic] synonym: "mucosa of organ of stomach cardiac region" EXACT [OBOL:automatic] synonym: "mucosa of pars cardiaca (gaster)" EXACT [OBOL:automatic] synonym: "mucosa of stomach cardiac region" EXACT [OBOL:automatic] synonym: "mucous membrane of cardia of stomach" EXACT [OBOL:automatic] synonym: "mucous membrane of cardial part of stomach" EXACT [OBOL:automatic] synonym: "mucous membrane of gastric cardia" EXACT [OBOL:automatic] synonym: "mucous membrane of pars cardiaca (gaster)" EXACT [OBOL:automatic] synonym: "mucous membrane of stomach cardiac region" EXACT [OBOL:automatic] synonym: "organ mucosa of cardia of stomach" EXACT [OBOL:automatic] synonym: "organ mucosa of cardial part of stomach" EXACT [OBOL:automatic] synonym: "organ mucosa of gastric cardia" EXACT [OBOL:automatic] synonym: "organ mucosa of pars cardiaca (gaster)" EXACT [OBOL:automatic] synonym: "organ mucosa of stomach cardiac region" EXACT [OBOL:automatic] synonym: "pars cardiaca (gaster) mucosa" EXACT [OBOL:automatic] synonym: "pars cardiaca (gaster) mucosa of organ" EXACT [OBOL:automatic] synonym: "pars cardiaca (gaster) mucous membrane" EXACT [OBOL:automatic] synonym: "pars cardiaca (gaster) organ mucosa" EXACT [OBOL:automatic] synonym: "stomach cardiac region mucosa" EXACT [OBOL:automatic] synonym: "stomach cardiac region mucosa of organ" EXACT [OBOL:automatic] synonym: "stomach cardiac region mucous membrane" EXACT [OBOL:automatic] synonym: "stomach cardiac region organ mucosa" EXACT [OBOL:automatic] xref: FMA:17456 is_a: UBERON:0001199 ! mucosa of stomach intersection_of: UBERON:0000344 ! mucosa intersection_of: BFO:0000050 UBERON:0001162 ! part of cardia of stomach relationship: BFO:0000050 UBERON:0001162 ! part of cardia of stomach [Term] id: UBERON:0004997 name: mucosa of pyloric antrum def: "A mucosa that is part of a pyloric antrum [Automatically generated definition]." [OBOL:automatic] synonym: "antral mucosa" EXACT [BTO:0004107] synonym: "antrum of stomach mucosa" EXACT [OBOL:automatic] synonym: "antrum of stomach mucosa of organ" EXACT [OBOL:automatic] synonym: "antrum of stomach mucous membrane" EXACT [OBOL:automatic] synonym: "antrum of stomach organ mucosa" EXACT [OBOL:automatic] synonym: "gastric antrum mucosa" RELATED [BTO:0004107] synonym: "mucosa of antrum of stomach" EXACT [OBOL:automatic] synonym: "mucosa of organ of antrum of stomach" EXACT [OBOL:automatic] synonym: "mucosa of organ of pyloric antrum" EXACT [OBOL:automatic] synonym: "mucosa of organ of stomach pyloric antrum" EXACT [OBOL:automatic] synonym: "mucosa of stomach pyloric antrum" EXACT [OBOL:automatic] synonym: "mucous membrane of antrum of stomach" EXACT [OBOL:automatic] synonym: "mucous membrane of pyloric antrum" EXACT [OBOL:automatic] synonym: "mucous membrane of stomach pyloric antrum" EXACT [OBOL:automatic] synonym: "organ mucosa of antrum of stomach" EXACT [OBOL:automatic] synonym: "organ mucosa of pyloric antrum" EXACT [OBOL:automatic] synonym: "organ mucosa of stomach pyloric antrum" EXACT [OBOL:automatic] synonym: "pyloric antrum mucosa" EXACT [OBOL:automatic] synonym: "pyloric antrum mucosa of organ" EXACT [OBOL:automatic] synonym: "pyloric antrum mucous membrane" EXACT [OBOL:automatic] synonym: "pyloric antrum organ mucosa" EXACT [OBOL:automatic] synonym: "stomach pyloric antrum mucosa" EXACT [OBOL:automatic] synonym: "stomach pyloric antrum mucosa of organ" EXACT [OBOL:automatic] synonym: "stomach pyloric antrum mucous membrane" EXACT [OBOL:automatic] synonym: "stomach pyloric antrum organ mucosa" EXACT [OBOL:automatic] xref: BTO:0004107 xref: FMA:17055 is_a: UBERON:0004998 ! mucosa of pylorus intersection_of: UBERON:0000344 ! mucosa intersection_of: BFO:0000050 UBERON:0001165 ! part of pyloric antrum relationship: BFO:0000050 UBERON:0001165 ! part of pyloric antrum relationship: BFO:0000050 UBERON:0004998 {source="BTO"} ! part of mucosa of pylorus property_value: skos:prefLabel "mucosa of pyloric antrum" xsd:string [Term] id: UBERON:0004998 name: mucosa of pylorus def: "A mucosa that is part of a pylorus [Automatically generated definition]." [OBOL:automatic] synonym: "antropyloric mucosa" RELATED [BTO:0002984] synonym: "mucosa of organ of pyloric part of stomach" EXACT [OBOL:automatic] synonym: "mucosa of organ of pylorus" EXACT [OBOL:automatic] synonym: "mucosa of organ of stomach pyloric region" EXACT [OBOL:automatic] synonym: "mucosa of pyloric part of stomach" EXACT [OBOL:automatic] synonym: "mucosa of stomach pyloric region" EXACT [OBOL:automatic] synonym: "mucous membrane of pyloric part of stomach" EXACT [OBOL:automatic] synonym: "mucous membrane of pylorus" EXACT [OBOL:automatic] synonym: "mucous membrane of stomach pyloric region" EXACT [OBOL:automatic] synonym: "organ mucosa of pyloric part of stomach" EXACT [OBOL:automatic] synonym: "organ mucosa of pylorus" EXACT [OBOL:automatic] synonym: "organ mucosa of stomach pyloric region" EXACT [OBOL:automatic] synonym: "pyloric part of stomach mucosa" EXACT [OBOL:automatic] synonym: "pyloric part of stomach mucosa of organ" EXACT [OBOL:automatic] synonym: "pyloric part of stomach mucous membrane" EXACT [OBOL:automatic] synonym: "pyloric part of stomach organ mucosa" EXACT [OBOL:automatic] synonym: "pylorus mucosa" EXACT [OBOL:automatic] synonym: "pylorus mucosa of organ" EXACT [OBOL:automatic] synonym: "pylorus mucous membrane" EXACT [OBOL:automatic] synonym: "pylorus organ mucosa" EXACT [OBOL:automatic] synonym: "stomach pyloric region mucosa" EXACT [OBOL:automatic] synonym: "stomach pyloric region mucosa of organ" EXACT [OBOL:automatic] synonym: "stomach pyloric region mucous membrane" EXACT [OBOL:automatic] synonym: "stomach pyloric region organ mucosa" EXACT [OBOL:automatic] xref: BTO:0004110 xref: EMAPA:27199 xref: FMA:17461 is_a: UBERON:0001199 ! mucosa of stomach intersection_of: UBERON:0000344 ! mucosa intersection_of: BFO:0000050 UBERON:0001166 ! part of pylorus relationship: BFO:0000050 UBERON:0001166 ! part of pylorus property_value: skos:prefLabel "mucosa of pylorus" xsd:string [Term] id: UBERON:0004999 name: mucosa of biliary tree def: "A mucosa that is part of a biliary tree [Automatically generated definition]." [OBOL:automatic] synonym: "biliary tract mucosa" EXACT [OBOL:automatic] synonym: "biliary tract mucosa of organ" EXACT [OBOL:automatic] synonym: "biliary tract mucous membrane" EXACT [OBOL:automatic] synonym: "biliary tract organ mucosa" EXACT [OBOL:automatic] synonym: "biliary tree mucosa" EXACT [OBOL:automatic] synonym: "biliary tree mucosa of organ" EXACT [OBOL:automatic] synonym: "biliary tree mucous membrane" EXACT [OBOL:automatic] synonym: "biliary tree organ mucosa" EXACT [OBOL:automatic] synonym: "mucosa of biliary tract" EXACT [OBOL:automatic] synonym: "mucosa of organ of biliary tract" EXACT [OBOL:automatic] synonym: "mucosa of organ of biliary tree" EXACT [OBOL:automatic] synonym: "mucous membrane of biliary tract" EXACT [OBOL:automatic] synonym: "mucous membrane of biliary tree" EXACT [OBOL:automatic] synonym: "organ mucosa of biliary tract" EXACT [OBOL:automatic] synonym: "organ mucosa of biliary tree" EXACT [OBOL:automatic] xref: FMA:14695 is_a: UBERON:0000344 ! mucosa intersection_of: UBERON:0000344 ! mucosa intersection_of: BFO:0000050 UBERON:0001173 ! part of biliary tree relationship: BFO:0000050 UBERON:0001173 ! part of biliary tree property_value: skos:prefLabel "mucosa of biliary tree" xsd:string [Term] id: UBERON:0005000 name: mucosa of common bile duct def: "A mucosa that is part of a common bile duct [Automatically generated definition]." [OBOL:automatic] synonym: "common bile duct mucosa" EXACT [OBOL:automatic] synonym: "common bile duct mucosa of organ" EXACT [OBOL:automatic] synonym: "common bile duct mucous membrane" EXACT [OBOL:automatic] synonym: "common bile duct organ mucosa" EXACT [OBOL:automatic] synonym: "common bile ductal mucosa" EXACT [FMA:14688] synonym: "ductus choledochus (biliaris) mucosa" EXACT [OBOL:automatic] synonym: "ductus choledochus (biliaris) mucosa of organ" EXACT [OBOL:automatic] synonym: "ductus choledochus (biliaris) mucous membrane" EXACT [OBOL:automatic] synonym: "ductus choledochus (biliaris) organ mucosa" EXACT [OBOL:automatic] synonym: "mucosa of ductus choledochus (biliaris)" EXACT [OBOL:automatic] synonym: "mucosa of organ of common bile duct" EXACT [OBOL:automatic] synonym: "mucosa of organ of ductus choledochus (biliaris)" EXACT [OBOL:automatic] synonym: "mucous membrane of common bile duct" EXACT [OBOL:automatic] synonym: "mucous membrane of ductus choledochus (biliaris)" EXACT [OBOL:automatic] synonym: "organ mucosa of common bile duct" EXACT [OBOL:automatic] synonym: "organ mucosa of ductus choledochus (biliaris)" EXACT [OBOL:automatic] xref: FMA:14688 is_a: UBERON:0004999 ! mucosa of biliary tree intersection_of: UBERON:0000344 ! mucosa intersection_of: BFO:0000050 UBERON:0001174 ! part of common bile duct relationship: BFO:0000050 UBERON:0001174 ! part of common bile duct property_value: skos:prefLabel "mucosa of common bile duct" xsd:string [Term] id: UBERON:0005001 name: mucosa of common hepatic duct def: "A mucosa that is part of a common hepatic duct [Automatically generated definition]." [OBOL:automatic] synonym: "common hepatic duct mucosa" EXACT [OBOL:automatic] synonym: "common hepatic duct mucosa of organ" EXACT [OBOL:automatic] synonym: "common hepatic duct mucous membrane" EXACT [OBOL:automatic] synonym: "common hepatic duct organ mucosa" EXACT [OBOL:automatic] synonym: "common hepatic ductal mucosa" EXACT [FMA:14691] synonym: "hepatic duct mucosa" EXACT [OBOL:automatic] synonym: "hepatic duct mucosa of organ" EXACT [OBOL:automatic] synonym: "hepatic duct mucous membrane" EXACT [OBOL:automatic] synonym: "hepatic duct organ mucosa" EXACT [OBOL:automatic] synonym: "mucosa of hepatic duct" EXACT [OBOL:automatic] synonym: "mucosa of organ of common hepatic duct" EXACT [OBOL:automatic] synonym: "mucosa of organ of hepatic duct" EXACT [OBOL:automatic] synonym: "mucous membrane of common hepatic duct" EXACT [OBOL:automatic] synonym: "mucous membrane of hepatic duct" EXACT [OBOL:automatic] synonym: "organ mucosa of common hepatic duct" EXACT [OBOL:automatic] synonym: "organ mucosa of hepatic duct" EXACT [OBOL:automatic] xref: FMA:14691 is_a: UBERON:0004999 ! mucosa of biliary tree intersection_of: UBERON:0000344 ! mucosa intersection_of: BFO:0000050 UBERON:0001175 ! part of common hepatic duct relationship: BFO:0000050 UBERON:0001175 ! part of common hepatic duct property_value: skos:prefLabel "mucosa of common hepatic duct" xsd:string [Term] id: UBERON:0005002 name: mucosa of right hepatic duct def: "A mucosa that is part of a right hepatic duct [Automatically generated definition]." [OBOL:automatic] synonym: "mucosa of organ of right hepatic duct" EXACT [OBOL:automatic] synonym: "mucous membrane of right hepatic duct" EXACT [OBOL:automatic] synonym: "organ mucosa of right hepatic duct" EXACT [OBOL:automatic] synonym: "right hepatic duct mucosa" EXACT [OBOL:automatic] synonym: "right hepatic duct mucosa of organ" EXACT [OBOL:automatic] synonym: "right hepatic duct mucous membrane" EXACT [OBOL:automatic] synonym: "right hepatic duct organ mucosa" EXACT [OBOL:automatic] synonym: "right hepatic ductal mucosa" EXACT [FMA:14692] xref: FMA:14692 is_a: UBERON:0004999 ! mucosa of biliary tree intersection_of: UBERON:0000344 ! mucosa intersection_of: BFO:0000050 UBERON:0001176 ! part of right hepatic duct relationship: BFO:0000050 UBERON:0001176 ! part of right hepatic duct property_value: skos:prefLabel "mucosa of right hepatic duct" xsd:string [Term] id: UBERON:0005003 name: mucosa of left hepatic duct def: "A mucosa that is part of a left hepatic duct [Automatically generated definition]." [OBOL:automatic] synonym: "left hepatic duct mucosa" EXACT [OBOL:automatic] synonym: "left hepatic duct mucosa of organ" EXACT [OBOL:automatic] synonym: "left hepatic duct mucous membrane" EXACT [OBOL:automatic] synonym: "left hepatic duct organ mucosa" EXACT [OBOL:automatic] synonym: "left hepatic ductal mucosa" EXACT [FMA:14693] synonym: "mucosa of organ of left hepatic duct" EXACT [OBOL:automatic] synonym: "mucous membrane of left hepatic duct" EXACT [OBOL:automatic] synonym: "organ mucosa of left hepatic duct" EXACT [OBOL:automatic] xref: FMA:14693 is_a: UBERON:0004999 ! mucosa of biliary tree intersection_of: UBERON:0000344 ! mucosa intersection_of: BFO:0000050 UBERON:0001177 ! part of left hepatic duct relationship: BFO:0000050 UBERON:0001177 ! part of left hepatic duct property_value: skos:prefLabel "mucosa of left hepatic duct" xsd:string [Term] id: UBERON:0005004 name: mucosa of right ureter def: "A mucosa that is part of a right ureter [Automatically generated definition]." [OBOL:automatic] synonym: "mucosa of organ of right ureter" EXACT [OBOL:automatic] synonym: "mucous membrane of right ureter" EXACT [OBOL:automatic] synonym: "organ mucosa of right ureter" EXACT [OBOL:automatic] synonym: "right ureter mucosa" EXACT [OBOL:automatic] synonym: "right ureter mucosa of organ" EXACT [OBOL:automatic] synonym: "right ureter mucous membrane" EXACT [OBOL:automatic] synonym: "right ureter organ mucosa" EXACT [OBOL:automatic] synonym: "right ureteral mucosa" EXACT [FMA:17806] xref: FMA:17806 is_a: UBERON:0004980 ! mucosa of ureter intersection_of: UBERON:0000344 ! mucosa intersection_of: BFO:0000050 UBERON:0001222 ! part of right ureter relationship: BFO:0000050 UBERON:0001222 ! part of right ureter [Term] id: UBERON:0005005 name: mucosa of left ureter def: "A mucosa that is part of a left ureter [Automatically generated definition]." [OBOL:automatic] subset: human_reference_atlas synonym: "left ureter mucosa" EXACT [OBOL:automatic] synonym: "left ureter mucosa of organ" EXACT [OBOL:automatic] synonym: "left ureter mucous membrane" EXACT [OBOL:automatic] synonym: "left ureter organ mucosa" EXACT [OBOL:automatic] synonym: "left ureteral mucosa" EXACT [FMA:17807] synonym: "mucosa of organ of left ureter" EXACT [OBOL:automatic] synonym: "mucous membrane of left ureter" EXACT [OBOL:automatic] synonym: "organ mucosa of left ureter" EXACT [OBOL:automatic] xref: FMA:17807 is_a: UBERON:0004980 ! mucosa of ureter intersection_of: UBERON:0000344 ! mucosa intersection_of: BFO:0000050 UBERON:0001223 ! part of left ureter relationship: BFO:0000050 UBERON:0001223 ! part of left ureter property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0005006 name: mucosa of renal pelvis def: "A mucosa that is part of a renal pelvis [Automatically generated definition]." [OBOL:automatic] synonym: "kidney pelvis mucosa" EXACT [OBOL:automatic] synonym: "kidney pelvis mucosa of organ" EXACT [OBOL:automatic] synonym: "kidney pelvis mucous membrane" EXACT [OBOL:automatic] synonym: "kidney pelvis organ mucosa" EXACT [OBOL:automatic] synonym: "mucosa of kidney pelvis" EXACT [OBOL:automatic] synonym: "mucosa of organ of kidney pelvis" EXACT [OBOL:automatic] synonym: "mucosa of organ of pelvis of ureter" EXACT [OBOL:automatic] synonym: "mucosa of organ of renal pelvis" EXACT [OBOL:automatic] synonym: "mucosa of pelvis of ureter" EXACT [OBOL:automatic] synonym: "mucous membrane of kidney pelvis" EXACT [OBOL:automatic] synonym: "mucous membrane of pelvis of ureter" EXACT [OBOL:automatic] synonym: "mucous membrane of renal pelvis" EXACT [OBOL:automatic] synonym: "organ mucosa of kidney pelvis" EXACT [OBOL:automatic] synonym: "organ mucosa of pelvis of ureter" EXACT [OBOL:automatic] synonym: "organ mucosa of renal pelvis" EXACT [OBOL:automatic] synonym: "pelvis of ureter mucosa" EXACT [OBOL:automatic] synonym: "pelvis of ureter mucosa of organ" EXACT [OBOL:automatic] synonym: "pelvis of ureter mucous membrane" EXACT [OBOL:automatic] synonym: "pelvis of ureter organ mucosa" EXACT [OBOL:automatic] synonym: "renal pelvic mucosa" EXACT [FMA:17931] synonym: "renal pelvis mucosa" EXACT [OBOL:automatic] synonym: "renal pelvis mucosa of organ" EXACT [OBOL:automatic] synonym: "renal pelvis mucous membrane" EXACT [OBOL:automatic] synonym: "renal pelvis organ mucosa" EXACT [OBOL:automatic] synonym: "tunica mucosa pelvis renalis" EXACT OMO:0003011 [FMA:17931, FMA:TA] xref: FMA:17931 xref: SCTID:243482002 is_a: UBERON:0000344 ! mucosa intersection_of: UBERON:0000344 ! mucosa intersection_of: BFO:0000050 UBERON:0001224 ! part of renal pelvis relationship: BFO:0000050 UBERON:0001224 ! part of renal pelvis [Term] id: UBERON:0005009 name: mucosa of trigone of urinary bladder def: "A mucosa that is part of a trigone of urinary bladder [Automatically generated definition]." [OBOL:automatic] subset: human_reference_atlas synonym: "deep trigone mucosa" EXACT [OBOL:automatic] synonym: "deep trigone mucosa of organ" EXACT [OBOL:automatic] synonym: "deep trigone mucous membrane" EXACT [OBOL:automatic] synonym: "deep trigone organ mucosa" EXACT [OBOL:automatic] synonym: "Lieutaud ' s trigone mucosa" EXACT [OBOL:automatic] synonym: "Lieutaud ' s trigone mucosa of organ" EXACT [OBOL:automatic] synonym: "Lieutaud ' s trigone mucous membrane" EXACT [OBOL:automatic] synonym: "Lieutaud ' s trigone organ mucosa" EXACT [OBOL:automatic] synonym: "mucosa of deep trigone" EXACT [OBOL:automatic] synonym: "mucosa of Lieutaud ' s trigone" EXACT [OBOL:automatic] synonym: "mucosa of organ of deep trigone" EXACT [OBOL:automatic] synonym: "mucosa of organ of Lieutaud ' s trigone" EXACT [OBOL:automatic] synonym: "mucosa of organ of trigone of bladder" EXACT [OBOL:automatic] synonym: "mucosa of organ of trigone of urinary bladder" EXACT [OBOL:automatic] synonym: "mucosa of organ of urinary bladder trigone" EXACT [OBOL:automatic] synonym: "mucosa of organ of vesical trigone" EXACT [OBOL:automatic] synonym: "mucosa of trigone of bladder" EXACT [OBOL:automatic] synonym: "mucosa of urinary bladder trigone" EXACT [OBOL:automatic] synonym: "mucosa of vesical trigone" EXACT [OBOL:automatic] synonym: "mucous membrane of deep trigone" EXACT [OBOL:automatic] synonym: "mucous membrane of Lieutaud ' s trigone" EXACT [OBOL:automatic] synonym: "mucous membrane of trigone of bladder" EXACT [OBOL:automatic] synonym: "mucous membrane of trigone of urinary bladder" EXACT [OBOL:automatic] synonym: "mucous membrane of urinary bladder trigone" EXACT [OBOL:automatic] synonym: "mucous membrane of vesical trigone" EXACT [OBOL:automatic] synonym: "organ mucosa of deep trigone" EXACT [OBOL:automatic] synonym: "organ mucosa of Lieutaud ' s trigone" EXACT [OBOL:automatic] synonym: "organ mucosa of trigone of bladder" EXACT [OBOL:automatic] synonym: "organ mucosa of trigone of urinary bladder" EXACT [OBOL:automatic] synonym: "organ mucosa of urinary bladder trigone" EXACT [OBOL:automatic] synonym: "organ mucosa of vesical trigone" EXACT [OBOL:automatic] synonym: "trigone of bladder mucosa" EXACT [OBOL:automatic] synonym: "trigone of bladder mucosa of organ" EXACT [OBOL:automatic] synonym: "trigone of bladder mucous membrane" EXACT [OBOL:automatic] synonym: "trigone of bladder organ mucosa" EXACT [OBOL:automatic] synonym: "trigone of urinary bladder mucosa" EXACT [OBOL:automatic] synonym: "trigone of urinary bladder mucosa of organ" EXACT [OBOL:automatic] synonym: "trigone of urinary bladder mucous membrane" EXACT [OBOL:automatic] synonym: "trigone of urinary bladder organ mucosa" EXACT [OBOL:automatic] synonym: "urinary bladder trigone mucosa" EXACT [OBOL:automatic] synonym: "urinary bladder trigone mucosa of organ" EXACT [OBOL:automatic] synonym: "urinary bladder trigone mucous membrane" EXACT [OBOL:automatic] synonym: "urinary bladder trigone organ mucosa" EXACT [OBOL:automatic] synonym: "vesical trigone mucosa" EXACT [OBOL:automatic] synonym: "vesical trigone mucosa of organ" EXACT [OBOL:automatic] synonym: "vesical trigone mucous membrane" EXACT [OBOL:automatic] synonym: "vesical trigone organ mucosa" EXACT [OBOL:automatic] xref: FMA:17847 is_a: UBERON:0001259 ! mucosa of urinary bladder intersection_of: UBERON:0000344 ! mucosa intersection_of: BFO:0000050 UBERON:0001257 ! part of trigone of urinary bladder relationship: BFO:0000050 UBERON:0001257 ! part of trigone of urinary bladder property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0005010 name: mucosa of neck of urinary bladder def: "A mucosa that is part of a neck of urinary bladder [Automatically generated definition]." [OBOL:automatic] synonym: "bladder neck mucosa" EXACT [OBOL:automatic] synonym: "bladder neck mucosa of organ" EXACT [OBOL:automatic] synonym: "bladder neck mucous membrane" EXACT [OBOL:automatic] synonym: "bladder neck organ mucosa" EXACT [OBOL:automatic] synonym: "mucosa of bladder neck" EXACT [OBOL:automatic] synonym: "mucosa of neck of bladder" EXACT [OBOL:automatic] synonym: "mucosa of organ of bladder neck" EXACT [OBOL:automatic] synonym: "mucosa of organ of neck of bladder" EXACT [OBOL:automatic] synonym: "mucosa of organ of neck of urinary bladder" EXACT [OBOL:automatic] synonym: "mucosa of organ of urinary bladder neck" EXACT [OBOL:automatic] synonym: "mucosa of organ of vesical neck" EXACT [OBOL:automatic] synonym: "mucosa of urinary bladder neck" EXACT [OBOL:automatic] synonym: "mucosa of vesical neck" EXACT [OBOL:automatic] synonym: "mucous membrane of bladder neck" EXACT [OBOL:automatic] synonym: "mucous membrane of neck of bladder" EXACT [OBOL:automatic] synonym: "mucous membrane of neck of urinary bladder" EXACT [OBOL:automatic] synonym: "mucous membrane of urinary bladder neck" EXACT [OBOL:automatic] synonym: "mucous membrane of vesical neck" EXACT [OBOL:automatic] synonym: "neck of bladder mucosa" EXACT [OBOL:automatic] synonym: "neck of bladder mucosa of organ" EXACT [OBOL:automatic] synonym: "neck of bladder mucous membrane" EXACT [OBOL:automatic] synonym: "neck of bladder organ mucosa" EXACT [OBOL:automatic] synonym: "neck of urinary bladder mucosa" EXACT [OBOL:automatic] synonym: "neck of urinary bladder mucosa of organ" EXACT [OBOL:automatic] synonym: "neck of urinary bladder mucous membrane" EXACT [OBOL:automatic] synonym: "neck of urinary bladder organ mucosa" EXACT [OBOL:automatic] synonym: "organ mucosa of bladder neck" EXACT [OBOL:automatic] synonym: "organ mucosa of neck of bladder" EXACT [OBOL:automatic] synonym: "organ mucosa of neck of urinary bladder" EXACT [OBOL:automatic] synonym: "organ mucosa of urinary bladder neck" EXACT [OBOL:automatic] synonym: "organ mucosa of vesical neck" EXACT [OBOL:automatic] synonym: "urinary bladder neck mucosa" EXACT [OBOL:automatic] synonym: "urinary bladder neck mucosa of organ" EXACT [OBOL:automatic] synonym: "urinary bladder neck mucous membrane" EXACT [OBOL:automatic] synonym: "vesical neck mucosa" EXACT [OBOL:automatic] synonym: "vesical neck mucosa of organ" EXACT [OBOL:automatic] synonym: "vesical neck mucous membrane" EXACT [OBOL:automatic] synonym: "vesical neck organ mucosa" EXACT [OBOL:automatic] xref: FMA:17846 is_a: UBERON:0001259 ! mucosa of urinary bladder intersection_of: UBERON:0000344 ! mucosa intersection_of: BFO:0000050 UBERON:0001258 ! part of neck of urinary bladder relationship: BFO:0000050 UBERON:0001258 ! part of neck of urinary bladder [Term] id: UBERON:0005011 name: mucosa of right fallopian tube def: "A mucosa that is part of a right uterine tube [Automatically generated definition]." [OBOL:automatic] synonym: "mucosa of organ of right fallopian tube" EXACT [OBOL:automatic] synonym: "mucosa of organ of right oviduct" EXACT [OBOL:automatic] synonym: "mucosa of organ of right uterine tube" EXACT [OBOL:automatic] synonym: "mucosa of right oviduct" EXACT [OBOL:automatic] synonym: "mucosa of right uterine tube" EXACT [] synonym: "mucous membrane of right fallopian tube" EXACT [OBOL:automatic] synonym: "mucous membrane of right oviduct" EXACT [OBOL:automatic] synonym: "mucous membrane of right uterine tube" EXACT [OBOL:automatic] synonym: "organ mucosa of right fallopian tube" EXACT [OBOL:automatic] synonym: "organ mucosa of right oviduct" EXACT [OBOL:automatic] synonym: "organ mucosa of right uterine tube" EXACT [OBOL:automatic] synonym: "right fallopian tube mucosa" EXACT [OBOL:automatic] synonym: "right fallopian tube mucosa of organ" EXACT [OBOL:automatic] synonym: "right fallopian tube mucous membrane" EXACT [OBOL:automatic] synonym: "right fallopian tube organ mucosa" EXACT [OBOL:automatic] synonym: "right oviduct mucosa" EXACT [OBOL:automatic] synonym: "right oviduct mucosa of organ" EXACT [OBOL:automatic] synonym: "right oviduct mucous membrane" EXACT [OBOL:automatic] synonym: "right oviduct organ mucosa" EXACT [OBOL:automatic] synonym: "right uterine tube mucosa" EXACT [OBOL:automatic] synonym: "right uterine tube mucosa of organ" EXACT [OBOL:automatic] synonym: "right uterine tube mucous membrane" EXACT [OBOL:automatic] synonym: "right uterine tube organ mucosa" EXACT [OBOL:automatic] xref: FMA:18452 is_a: UBERON:0005048 ! mucosa of fallopian tube intersection_of: UBERON:0000344 ! mucosa intersection_of: BFO:0000050 UBERON:0001302 ! part of right fallopian tube relationship: BFO:0000050 UBERON:0001302 ! part of right fallopian tube [Term] id: UBERON:0005012 name: mucosa of left fallopian tube def: "A mucosa that is part of a left uterine tube [Automatically generated definition]." [OBOL:automatic] synonym: "left fallopian tube mucosa" EXACT [OBOL:automatic] synonym: "left fallopian tube mucosa of organ" EXACT [OBOL:automatic] synonym: "left fallopian tube mucous membrane" EXACT [OBOL:automatic] synonym: "left fallopian tube organ mucosa" EXACT [OBOL:automatic] synonym: "left oviduct mucosa" EXACT [OBOL:automatic] synonym: "left oviduct mucosa of organ" EXACT [OBOL:automatic] synonym: "left oviduct mucous membrane" EXACT [OBOL:automatic] synonym: "left oviduct organ mucosa" EXACT [OBOL:automatic] synonym: "left uterine tube mucosa" EXACT [OBOL:automatic] synonym: "left uterine tube mucosa of organ" EXACT [OBOL:automatic] synonym: "left uterine tube mucous membrane" EXACT [OBOL:automatic] synonym: "left uterine tube organ mucosa" EXACT [OBOL:automatic] synonym: "mucosa of left oviduct" EXACT [OBOL:automatic] synonym: "mucosa of left uterine tube" EXACT [] synonym: "mucosa of organ of left fallopian tube" EXACT [OBOL:automatic] synonym: "mucosa of organ of left oviduct" EXACT [OBOL:automatic] synonym: "mucosa of organ of left uterine tube" EXACT [OBOL:automatic] synonym: "mucous membrane of left fallopian tube" EXACT [OBOL:automatic] synonym: "mucous membrane of left oviduct" EXACT [OBOL:automatic] synonym: "mucous membrane of left uterine tube" EXACT [OBOL:automatic] synonym: "organ mucosa of left fallopian tube" EXACT [OBOL:automatic] synonym: "organ mucosa of left oviduct" EXACT [OBOL:automatic] synonym: "organ mucosa of left uterine tube" EXACT [OBOL:automatic] xref: FMA:18453 is_a: UBERON:0005048 ! mucosa of fallopian tube intersection_of: UBERON:0000344 ! mucosa intersection_of: BFO:0000050 UBERON:0001303 ! part of left fallopian tube relationship: BFO:0000050 UBERON:0001303 ! part of left fallopian tube [Term] id: UBERON:0005013 name: mucosa of male urethra def: "A mucosa that is part of a male urethra [Automatically generated definition]." [OBOL:automatic] synonym: "male urethra mucosa" EXACT [OBOL:automatic] synonym: "male urethra mucosa of organ" EXACT [OBOL:automatic] synonym: "male urethra mucous membrane" EXACT [OBOL:automatic] synonym: "male urethra organ mucosa" EXACT [OBOL:automatic] synonym: "mucosa of organ of male urethra" EXACT [OBOL:automatic] synonym: "mucous membrane of male urethra" EXACT [OBOL:automatic] synonym: "organ mucosa of male urethra" EXACT [OBOL:automatic] xref: FMA:239937 is_a: UBERON:0012299 ! mucosa of urethra intersection_of: UBERON:0000344 ! mucosa intersection_of: BFO:0000050 UBERON:0001333 ! part of male urethra relationship: BFO:0000050 UBERON:0001333 ! part of male urethra [Term] id: UBERON:0005014 name: mucosa of female urethra def: "A mucosa that is part of a female urethra [Automatically generated definition]." [OBOL:automatic] synonym: "female urethra mucosa" EXACT [OBOL:automatic] synonym: "female urethra mucosa of organ" EXACT [OBOL:automatic] synonym: "female urethra mucous membrane" EXACT [OBOL:automatic] synonym: "female urethra organ mucosa" EXACT [OBOL:automatic] synonym: "mucosa of organ of female urethra" EXACT [OBOL:automatic] synonym: "mucous membrane of female urethra" EXACT [OBOL:automatic] synonym: "organ mucosa of female urethra" EXACT [OBOL:automatic] xref: FMA:239940 is_a: UBERON:0012299 ! mucosa of urethra intersection_of: UBERON:0000344 ! mucosa intersection_of: BFO:0000050 UBERON:0001334 ! part of female urethra relationship: BFO:0000050 UBERON:0001334 ! part of female urethra [Term] id: UBERON:0005015 name: mucosa of prostatic urethra def: "A mucosa that is part of a prostatic urethra [Automatically generated definition]." [OBOL:automatic] synonym: "mucosa of organ of prostatic part of urethra" EXACT [OBOL:automatic] synonym: "mucosa of organ of prostatic urethra" EXACT [OBOL:automatic] synonym: "mucosa of prostatic part of urethra" EXACT [OBOL:automatic] synonym: "mucous membrane of prostatic part of urethra" EXACT [OBOL:automatic] synonym: "mucous membrane of prostatic urethra" EXACT [OBOL:automatic] synonym: "organ mucosa of prostatic part of urethra" EXACT [OBOL:automatic] synonym: "organ mucosa of prostatic urethra" EXACT [OBOL:automatic] synonym: "prostatic part of urethra mucosa" EXACT [OBOL:automatic] synonym: "prostatic part of urethra mucosa of organ" EXACT [OBOL:automatic] synonym: "prostatic part of urethra mucous membrane" EXACT [OBOL:automatic] synonym: "prostatic part of urethra organ mucosa" EXACT [OBOL:automatic] synonym: "prostatic urethra mucosa" EXACT [OBOL:automatic] synonym: "prostatic urethra mucosa of organ" EXACT [OBOL:automatic] synonym: "prostatic urethra mucous membrane" EXACT [OBOL:automatic] synonym: "prostatic urethra organ mucosa" EXACT [OBOL:automatic] synonym: "prostatic urethral mucosa" EXACT [FMA:77079] synonym: "tunica mucosa urethrae prosticae" EXACT OMO:0003011 [FMA:77079, FMA:TA] xref: FMA:77079 is_a: UBERON:0005013 ! mucosa of male urethra intersection_of: UBERON:0000344 ! mucosa intersection_of: BFO:0000050 UBERON:0001335 ! part of prostatic urethra relationship: BFO:0000050 UBERON:0001335 ! part of prostatic urethra [Term] id: UBERON:0005017 name: mucosa of lacrimal sac def: "A mucosa that is part of a lacrimal sac [Automatically generated definition]." [OBOL:automatic] synonym: "lacrimal sac mucosa" EXACT [OBOL:automatic] synonym: "lacrimal sac mucosa of organ" EXACT [OBOL:automatic] synonym: "lacrimal sac mucous membrane" EXACT [OBOL:automatic] synonym: "lacrimal sac organ mucosa" EXACT [OBOL:automatic] synonym: "mucosa of organ of lacrimal sac" EXACT [OBOL:automatic] synonym: "mucous membrane of lacrimal sac" EXACT [OBOL:automatic] synonym: "organ mucosa of lacrimal sac" EXACT [OBOL:automatic] xref: FMA:72061 is_a: UBERON:0005043 ! mucosa of nasolacrimal duct intersection_of: UBERON:0000344 ! mucosa intersection_of: BFO:0000050 UBERON:0001351 ! part of lacrimal sac relationship: BFO:0000050 UBERON:0001351 ! part of lacrimal sac [Term] id: UBERON:0005020 name: mucosa of tongue def: "A mucosa that is part of a tongue [Automatically generated definition]." [OBOL:automatic] subset: efo_slim subset: human_reference_atlas synonym: "lingual mucosa" EXACT [FMA:54807] synonym: "mucosa of organ of tongue" EXACT [OBOL:automatic] synonym: "mucous membrane of tongue" EXACT [OBOL:automatic] synonym: "organ mucosa of tongue" EXACT [OBOL:automatic] synonym: "tongue mucosa" EXACT [OBOL:automatic] synonym: "tongue mucosa of organ" EXACT [OBOL:automatic] synonym: "tongue mucous membrane" EXACT [OBOL:automatic] synonym: "tongue organ mucosa" EXACT [OBOL:automatic] synonym: "tunica mucosa linguae" EXACT OMO:0003011 [FMA:54807, FMA:TA] xref: EFO:0002553 xref: FMA:54807 xref: SCTID:362092002 is_a: UBERON:0003729 ! mouth mucosa intersection_of: UBERON:0000344 ! mucosa intersection_of: BFO:0000050 UBERON:0001723 ! part of tongue relationship: BFO:0000050 UBERON:0001723 ! part of tongue property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "mucosa of tongue" xsd:string [Term] id: UBERON:0005022 name: mucosa of nasopharynx def: "A mucosa that is part of a nasopharynx [Automatically generated definition]." [OBOL:automatic] synonym: "mucosa of nasal part of pharynx" EXACT [OBOL:automatic] synonym: "mucosa of organ of nasal part of pharynx" EXACT [OBOL:automatic] synonym: "mucosa of organ of nasopharynx" EXACT [OBOL:automatic] synonym: "mucosa of organ of rhinopharynx" EXACT [OBOL:automatic] synonym: "mucosa of rhinopharynx" EXACT [OBOL:automatic] synonym: "mucous membrane of nasal part of pharynx" EXACT [OBOL:automatic] synonym: "mucous membrane of nasopharynx" EXACT [OBOL:automatic] synonym: "mucous membrane of rhinopharynx" EXACT [OBOL:automatic] synonym: "nasal part of pharynx mucosa" EXACT [OBOL:automatic] synonym: "nasal part of pharynx mucosa of organ" EXACT [OBOL:automatic] synonym: "nasal part of pharynx mucous membrane" EXACT [OBOL:automatic] synonym: "nasal part of pharynx organ mucosa" EXACT [OBOL:automatic] synonym: "nasopharynx mucosa" EXACT [OBOL:automatic] synonym: "nasopharynx mucosa of organ" EXACT [OBOL:automatic] synonym: "nasopharynx mucous membrane" EXACT [OBOL:automatic] synonym: "nasopharynx organ mucosa" EXACT [OBOL:automatic] synonym: "organ mucosa of nasal part of pharynx" EXACT [OBOL:automatic] synonym: "organ mucosa of nasopharynx" EXACT [OBOL:automatic] synonym: "organ mucosa of rhinopharynx" EXACT [OBOL:automatic] synonym: "rhinopharynx mucosa" EXACT [OBOL:automatic] synonym: "rhinopharynx mucosa of organ" EXACT [OBOL:automatic] synonym: "rhinopharynx mucous membrane" EXACT [OBOL:automatic] synonym: "rhinopharynx organ mucosa" EXACT [OBOL:automatic] xref: FMA:54971 xref: SCTID:361938001 is_a: UBERON:0000355 ! pharyngeal mucosa intersection_of: UBERON:0000344 ! mucosa intersection_of: BFO:0000050 UBERON:0001728 ! part of nasopharynx relationship: BFO:0000050 UBERON:0001728 ! part of nasopharynx [Term] id: UBERON:0005026 name: mucosa of middle ear def: "A mucosa that is part of a middle ear [Automatically generated definition]." [OBOL:automatic] synonym: "middle ear mucosa" EXACT [OBOL:automatic] synonym: "middle ear mucosa of organ" EXACT [OBOL:automatic] synonym: "middle ear mucous membrane" EXACT [OBOL:automatic] synonym: "middle ear organ mucosa" EXACT [OBOL:automatic] synonym: "mucosa of organ of middle ear" EXACT [OBOL:automatic] synonym: "mucosa of tympanic cavity" EXACT [FMA:59663] synonym: "mucous membrane of middle ear" EXACT [OBOL:automatic] synonym: "organ mucosa of middle ear" EXACT [OBOL:automatic] synonym: "tunica mucosa cavitatis tympanicae" EXACT OMO:0003011 [FMA:59663, FMA:TA] xref: CALOHA:TS-0631 xref: FMA:59663 is_a: UBERON:0000344 ! mucosa intersection_of: UBERON:0000344 ! mucosa intersection_of: BFO:0000050 UBERON:0001756 ! part of middle ear relationship: BFO:0000050 UBERON:0001756 ! part of middle ear [Term] id: UBERON:0005029 name: mucosa of lacrimal canaliculus def: "A mucosa that is part of a lacrimal canaliculus [Automatically generated definition]." [OBOL:automatic] synonym: "lacrimal canalicular mucosa" EXACT [FMA:85366] synonym: "lacrimal canaliculus mucosa" EXACT [OBOL:automatic] synonym: "lacrimal canaliculus mucosa of organ" EXACT [OBOL:automatic] synonym: "lacrimal canaliculus mucous membrane" EXACT [OBOL:automatic] synonym: "lacrimal canaliculus organ mucosa" EXACT [OBOL:automatic] synonym: "mucosa of organ of lacrimal canaliculus" EXACT [OBOL:automatic] synonym: "mucous membrane of lacrimal canaliculus" EXACT [OBOL:automatic] synonym: "organ mucosa of lacrimal canaliculus" EXACT [OBOL:automatic] xref: FMA:85366 is_a: UBERON:0000344 ! mucosa intersection_of: UBERON:0000344 ! mucosa intersection_of: BFO:0000050 UBERON:0001770 ! part of lacrimal canaliculus relationship: BFO:0000050 UBERON:0001770 ! part of lacrimal canaliculus [Term] id: UBERON:0005031 name: mucosa of upper lip def: "A mucosa that is part of a upper lip [Automatically generated definition]." [OBOL:automatic] synonym: "mucosa of organ of upper lip" EXACT [OBOL:automatic] synonym: "mucous membrane of upper lip" EXACT [OBOL:automatic] synonym: "organ mucosa of upper lip" EXACT [OBOL:automatic] synonym: "upper labial mucosa" EXACT [UBERON:cjm] synonym: "upper lip mucosa" EXACT [OBOL:automatic] synonym: "upper lip mucosa of organ" EXACT [OBOL:automatic] synonym: "upper lip mucous membrane" EXACT [OBOL:automatic] synonym: "upper lip organ mucosa" EXACT [OBOL:automatic] xref: FMA:59832 xref: NCIT:C12224 xref: SCTID:362088009 xref: UMLS:C0226933 {source="ncithesaurus:Mucosa_of_the_Upper_Lip"} is_a: UBERON:0036294 ! mucosa of lip intersection_of: UBERON:0000344 ! mucosa intersection_of: BFO:0000050 UBERON:0001834 ! part of upper lip relationship: BFO:0000050 UBERON:0001834 ! part of upper lip property_value: skos:prefLabel "mucosa of upper lip" xsd:string [Term] id: UBERON:0005032 name: mucosa of lower lip def: "A mucosa that is part of a lower lip [Automatically generated definition]." [OBOL:automatic] synonym: "lower labial mucosa" EXACT [UBERON:cjm] synonym: "lower lip mucosa" EXACT [OBOL:automatic] synonym: "lower lip mucosa of organ" EXACT [OBOL:automatic] synonym: "lower lip mucous membrane" EXACT [OBOL:automatic] synonym: "lower lip organ mucosa" EXACT [OBOL:automatic] synonym: "mucosa of organ of lower lip" EXACT [OBOL:automatic] synonym: "mucous membrane of lower lip" EXACT [OBOL:automatic] synonym: "organ mucosa of lower lip" EXACT [OBOL:automatic] xref: FMA:59833 xref: NCIT:C12225 xref: SCTID:362089001 xref: UMLS:C0226939 {source="ncithesaurus:Mucosa_of_the_Lower_Lip"} is_a: UBERON:0036294 ! mucosa of lip intersection_of: UBERON:0000344 ! mucosa intersection_of: BFO:0000050 UBERON:0001835 ! part of lower lip relationship: BFO:0000050 UBERON:0001835 ! part of lower lip property_value: skos:prefLabel "mucosa of lower lip" xsd:string [Term] id: UBERON:0005033 name: mucosa of gallbladder def: "A mucosa that is part of a gallbladder [Automatically generated definition]." [OBOL:automatic] synonym: "gall bladder mucosa" EXACT [OBOL:automatic] synonym: "gall bladder mucosa of organ" EXACT [OBOL:automatic] synonym: "gall bladder mucous membrane" EXACT [OBOL:automatic] synonym: "gall bladder organ mucosa" EXACT [OBOL:automatic] synonym: "gallbladder mucosa" EXACT [OBOL:automatic] synonym: "gallbladder mucosa of organ" EXACT [OBOL:automatic] synonym: "gallbladder mucous membrane" EXACT [OBOL:automatic] synonym: "gallbladder organ mucosa" EXACT [OBOL:automatic] synonym: "mucosa of gall bladder" EXACT [OBOL:automatic] synonym: "mucosa of organ of gall bladder" EXACT [OBOL:automatic] synonym: "mucosa of organ of gallbladder" EXACT [OBOL:automatic] synonym: "mucous membrane of gall bladder" EXACT [OBOL:automatic] synonym: "mucous membrane of gallbladder" EXACT [OBOL:automatic] synonym: "organ mucosa of gall bladder" EXACT [OBOL:automatic] synonym: "organ mucosa of gallbladder" EXACT [OBOL:automatic] synonym: "tunica mucosa (vesica biliaris)" EXACT [FMA:14662] synonym: "tunica mucosa vesicae biliaris" EXACT OMO:0003011 [FMA:14662, FMA:TA] xref: FMA:14662 xref: SCTID:362196002 is_a: UBERON:0000344 ! mucosa intersection_of: UBERON:0000344 ! mucosa intersection_of: BFO:0000050 UBERON:0002110 ! part of gallbladder relationship: BFO:0000050 UBERON:0002110 ! part of gallbladder property_value: skos:prefLabel "mucosa of gallbladder" xsd:string [Term] id: UBERON:0005037 name: mucosa of lobar bronchus def: "A mucosa that is part of a lobar bronchus [Automatically generated definition]." [OBOL:automatic] synonym: "lobar bronchial mucosa" EXACT [FMA:62668] synonym: "lobar bronchus mucosa" EXACT [OBOL:automatic] synonym: "lobar bronchus mucosa of organ" EXACT [OBOL:automatic] synonym: "lobar bronchus mucous membrane" EXACT [OBOL:automatic] synonym: "lobar bronchus organ mucosa" EXACT [OBOL:automatic] synonym: "mucosa of organ of lobar bronchus" EXACT [OBOL:automatic] synonym: "mucosa of organ of secondary bronchus" EXACT [OBOL:automatic] synonym: "mucosa of secondary bronchus" EXACT [OBOL:automatic] synonym: "mucous membrane of lobar bronchus" EXACT [OBOL:automatic] synonym: "mucous membrane of secondary bronchus" EXACT [OBOL:automatic] synonym: "organ mucosa of lobar bronchus" EXACT [OBOL:automatic] synonym: "organ mucosa of secondary bronchus" EXACT [OBOL:automatic] synonym: "secondary bronchus mucosa" EXACT [OBOL:automatic] synonym: "secondary bronchus mucosa of organ" EXACT [OBOL:automatic] synonym: "secondary bronchus mucous membrane" EXACT [OBOL:automatic] synonym: "secondary bronchus organ mucosa" EXACT [OBOL:automatic] xref: FMA:62668 is_a: UBERON:0000410 ! bronchial mucosa intersection_of: UBERON:0000344 ! mucosa intersection_of: BFO:0000050 UBERON:0002183 ! part of lobar bronchus relationship: BFO:0000050 UBERON:0002183 ! part of lobar bronchus [Term] id: UBERON:0005038 name: mucosa of segmental bronchus def: "A mucosa that is part of a segmental bronchus [Automatically generated definition]." [OBOL:automatic] synonym: "mucosa of organ of segmental bronchus" EXACT [OBOL:automatic] synonym: "mucosa of organ of tertiary bronchus" EXACT [OBOL:automatic] synonym: "mucosa of tertiary bronchus" EXACT [OBOL:automatic] synonym: "mucous membrane of segmental bronchus" EXACT [OBOL:automatic] synonym: "mucous membrane of tertiary bronchus" EXACT [OBOL:automatic] synonym: "organ mucosa of segmental bronchus" EXACT [OBOL:automatic] synonym: "organ mucosa of tertiary bronchus" EXACT [OBOL:automatic] synonym: "segmental bronchial mucosa" EXACT [FMA:62666] synonym: "segmental bronchus mucosa" EXACT [OBOL:automatic] synonym: "segmental bronchus mucosa of organ" EXACT [OBOL:automatic] synonym: "segmental bronchus mucous membrane" EXACT [OBOL:automatic] synonym: "segmental bronchus organ mucosa" EXACT [OBOL:automatic] synonym: "tertiary bronchus mucosa" EXACT [OBOL:automatic] synonym: "tertiary bronchus mucosa of organ" EXACT [OBOL:automatic] synonym: "tertiary bronchus mucous membrane" EXACT [OBOL:automatic] synonym: "tertiary bronchus organ mucosa" EXACT [OBOL:automatic] xref: FMA:62666 is_a: UBERON:0000410 ! bronchial mucosa intersection_of: UBERON:0000344 ! mucosa intersection_of: BFO:0000050 UBERON:0002184 ! part of segmental bronchus relationship: BFO:0000050 UBERON:0002184 ! part of segmental bronchus [Term] id: UBERON:0005039 name: mucosa of bronchiole def: "A mucosa that is part of a bronchiole [Automatically generated definition]." [OBOL:automatic] synonym: "bronchiole mucosa" EXACT [OBOL:automatic] synonym: "bronchiole mucosa of organ" EXACT [OBOL:automatic] synonym: "bronchiole mucous membrane" EXACT [OBOL:automatic] synonym: "bronchiole organ mucosa" EXACT [OBOL:automatic] synonym: "mucosa of organ of bronchiole" EXACT [OBOL:automatic] synonym: "mucous membrane of bronchiole" EXACT [OBOL:automatic] synonym: "organ mucosa of bronchiole" EXACT [OBOL:automatic] xref: FMA:62774 xref: SCTID:10887006 is_a: UBERON:0004785 ! respiratory system mucosa intersection_of: UBERON:0000344 ! mucosa intersection_of: BFO:0000050 UBERON:0002186 ! part of bronchiole relationship: BFO:0000050 UBERON:0002186 ! part of bronchiole [Term] id: UBERON:0005040 name: mucosa of terminal bronchiole def: "A mucosa that is part of a terminal bronchiole [Automatically generated definition]." [OBOL:automatic] synonym: "bronchiolus terminalis mucosa" EXACT [OBOL:automatic] synonym: "bronchiolus terminalis mucosa of organ" EXACT [OBOL:automatic] synonym: "bronchiolus terminalis mucous membrane" EXACT [OBOL:automatic] synonym: "bronchiolus terminalis organ mucosa" EXACT [OBOL:automatic] synonym: "mucosa of bronchiolus terminalis" EXACT [OBOL:automatic] synonym: "mucosa of organ of bronchiolus terminalis" EXACT [OBOL:automatic] synonym: "mucosa of organ of terminal bronchiole" EXACT [OBOL:automatic] synonym: "mucous membrane of bronchiolus terminalis" EXACT [OBOL:automatic] synonym: "mucous membrane of terminal bronchiole" EXACT [OBOL:automatic] synonym: "organ mucosa of bronchiolus terminalis" EXACT [OBOL:automatic] synonym: "organ mucosa of terminal bronchiole" EXACT [OBOL:automatic] synonym: "terminal bronchiole mucosa" EXACT [OBOL:automatic] synonym: "terminal bronchiole mucosa of organ" EXACT [OBOL:automatic] synonym: "terminal bronchiole mucous membrane" EXACT [OBOL:automatic] synonym: "terminal bronchiole organ mucosa" EXACT [OBOL:automatic] xref: FMA:263232 is_a: UBERON:0005039 ! mucosa of bronchiole intersection_of: UBERON:0000344 ! mucosa intersection_of: BFO:0000050 UBERON:0002187 ! part of terminal bronchiole relationship: BFO:0000050 UBERON:0002187 ! part of terminal bronchiole [Term] id: UBERON:0005041 name: mucosa of respiratory bronchiole def: "A mucosa that is part of a respiratory bronchiole [Automatically generated definition]." [OBOL:automatic] synonym: "bronchiolus respiratorius mucosa" EXACT [OBOL:automatic] synonym: "bronchiolus respiratorius mucosa of organ" EXACT [OBOL:automatic] synonym: "bronchiolus respiratorius mucous membrane" EXACT [OBOL:automatic] synonym: "bronchiolus respiratorius organ mucosa" EXACT [OBOL:automatic] synonym: "mucosa of bronchiolus respiratorius" EXACT [OBOL:automatic] synonym: "mucosa of organ of bronchiolus respiratorius" EXACT [OBOL:automatic] synonym: "mucosa of organ of respiratory bronchiole" EXACT [OBOL:automatic] synonym: "mucous membrane of bronchiolus respiratorius" EXACT [OBOL:automatic] synonym: "mucous membrane of respiratory bronchiole" EXACT [OBOL:automatic] synonym: "organ mucosa of bronchiolus respiratorius" EXACT [OBOL:automatic] synonym: "organ mucosa of respiratory bronchiole" EXACT [OBOL:automatic] synonym: "respiratory bronchiole mucosa" EXACT [OBOL:automatic] synonym: "respiratory bronchiole mucosa of organ" EXACT [OBOL:automatic] synonym: "respiratory bronchiole mucous membrane" EXACT [OBOL:automatic] synonym: "respiratory bronchiole organ mucosa" EXACT [OBOL:automatic] xref: FMA:263238 is_a: UBERON:0005039 ! mucosa of bronchiole intersection_of: UBERON:0000344 ! mucosa intersection_of: BFO:0000050 UBERON:0002188 ! part of respiratory bronchiole relationship: BFO:0000050 UBERON:0002188 ! part of respiratory bronchiole [Term] id: UBERON:0005042 name: inner epithelial layer of tympanic membrane def: "A portion of the tympanic cavity epithelium which makes up the outer (cuticular) layer of the tympanic membrane." [https://orcid.org/0000-0002-6601-2165, PMID:11237469] synonym: "mucosa of tympanic membrane" EXACT [FMA:56844] synonym: "mucous layer of tympanic membrane" EXACT [FMA:56844] synonym: "mucous stratum of tympanic membrane" EXACT [FMA:56844] synonym: "tympanic membrane external middle ear cavity epithelial component" EXACT [https://orcid.org/0000-0002-6601-2165] synonym: "tympanic membrane mucosa" EXACT [FMA:56844] xref: FMA:56844 xref: SCTID:36411006 is_a: UBERON:0009647 ! tympanic membrane epithelium intersection_of: UBERON:0009647 ! tympanic membrane epithelium intersection_of: BFO:0000050 UBERON:0010063 ! part of tympanic cavity epithelium relationship: BFO:0000050 UBERON:0010063 ! part of tympanic cavity epithelium [Term] id: UBERON:0005043 name: mucosa of nasolacrimal duct def: "A mucosa that is part of a nasolacrimal duct [Automatically generated definition]." [OBOL:automatic] synonym: "mucosa of organ of nasolacrimal duct" EXACT [OBOL:automatic] synonym: "mucous membrane of nasolacrimal duct" EXACT [OBOL:automatic] synonym: "nasolacrimal duct mucosa" EXACT [OBOL:automatic] synonym: "nasolacrimal duct mucosa of organ" EXACT [OBOL:automatic] synonym: "nasolacrimal duct mucous membrane" EXACT [OBOL:automatic] synonym: "nasolacrimal duct organ mucosa" EXACT [OBOL:automatic] synonym: "nasolacrimal ductal mucosa" EXACT [FMA:59664] synonym: "organ mucosa of nasolacrimal duct" EXACT [OBOL:automatic] xref: FMA:59664 is_a: UBERON:0000344 ! mucosa intersection_of: UBERON:0000344 ! mucosa intersection_of: BFO:0000050 UBERON:0002392 ! part of nasolacrimal duct relationship: BFO:0000050 UBERON:0002392 ! part of nasolacrimal duct [Term] id: UBERON:0005044 name: mucosa of pharyngotympanic tube def: "A mucosa that is part of a pharyngotympanic tube [Automatically generated definition]." [OBOL:automatic] synonym: "auditory tube mucosa" EXACT [OBOL:automatic] synonym: "auditory tube mucosa of organ" EXACT [OBOL:automatic] synonym: "auditory tube mucous membrane" EXACT [OBOL:automatic] synonym: "auditory tube organ mucosa" EXACT [OBOL:automatic] synonym: "internal auditory tube mucosa" EXACT [OBOL:automatic] synonym: "internal auditory tube mucosa of organ" EXACT [OBOL:automatic] synonym: "internal auditory tube mucous membrane" EXACT [OBOL:automatic] synonym: "internal auditory tube organ mucosa" EXACT [OBOL:automatic] synonym: "mucosa of auditory tube" EXACT [OBOL:automatic] synonym: "mucosa of internal auditory tube" EXACT [OBOL:automatic] synonym: "mucosa of organ of auditory tube" EXACT [OBOL:automatic] synonym: "mucosa of organ of internal auditory tube" EXACT [OBOL:automatic] synonym: "mucosa of organ of pharyngotympanic tube" EXACT [OBOL:automatic] synonym: "mucous membrane of auditory tube" EXACT [OBOL:automatic] synonym: "mucous membrane of internal auditory tube" EXACT [OBOL:automatic] synonym: "mucous membrane of pharyngotympanic tube" EXACT [OBOL:automatic] synonym: "mucuous membrane of eustachian tube" EXACT [FMA:60109] synonym: "mucuous membrane of pharyngotympanic tube" EXACT [FMA:60109] synonym: "organ mucosa of auditory tube" EXACT [OBOL:automatic] synonym: "organ mucosa of internal auditory tube" EXACT [OBOL:automatic] synonym: "organ mucosa of pharyngotympanic tube" EXACT [OBOL:automatic] synonym: "pharyngotympanic tube mucosa" EXACT [OBOL:automatic] synonym: "pharyngotympanic tube mucosa of organ" EXACT [OBOL:automatic] synonym: "pharyngotympanic tube mucous membrane" EXACT [OBOL:automatic] synonym: "pharyngotympanic tube organ mucosa" EXACT [OBOL:automatic] synonym: "tunica mucosa (tuba auditiva)" EXACT [FMA:60109] synonym: "tunica mucosa (tuba auditoria)" EXACT [FMA:60109] xref: FMA:60109 is_a: UBERON:0005026 ! mucosa of middle ear intersection_of: UBERON:0000344 ! mucosa intersection_of: BFO:0000050 UBERON:0002393 ! part of pharyngotympanic tube relationship: BFO:0000050 UBERON:0002393 ! part of pharyngotympanic tube [Term] id: UBERON:0005048 name: mucosa of fallopian tube def: "A mucosa that is part of a fallopian tube [Automatically generated definition]." [OBOL:automatic] synonym: "fallopian tube mucosa" EXACT [OBOL:automatic] synonym: "fallopian tube mucosa of organ" EXACT [OBOL:automatic] synonym: "fallopian tube mucous membrane" EXACT [OBOL:automatic] synonym: "fallopian tube organ mucosa" EXACT [OBOL:automatic] synonym: "mucosa of organ of fallopian tube" EXACT [OBOL:automatic] synonym: "mucosa of organ of uterine tube" EXACT [OBOL:automatic] synonym: "mucosa of oviduct" EXACT [FMA:18319] synonym: "mucosa of uterine tube" EXACT [] synonym: "mucous membrane of fallopian tube" EXACT [OBOL:automatic] synonym: "mucous membrane of uterine tube" EXACT [OBOL:automatic] synonym: "organ mucosa of fallopian tube" EXACT [OBOL:automatic] synonym: "organ mucosa of uterine tube" EXACT [OBOL:automatic] synonym: "tunica mucosa tubae uterinae" EXACT OMO:0003011 [FMA:18319, FMA:TA] synonym: "uterine tubal mucosa" EXACT [FMA:18319] synonym: "uterine tube mucosa" EXACT [OBOL:automatic] synonym: "uterine tube mucosa of organ" EXACT [OBOL:automatic] synonym: "uterine tube mucous membrane" EXACT [OBOL:automatic] synonym: "uterine tube organ mucosa" EXACT [OBOL:automatic] xref: FMA:18319 is_a: UBERON:0019042 ! reproductive system mucosa intersection_of: UBERON:0000344 ! mucosa intersection_of: BFO:0000050 UBERON:0003889 ! part of fallopian tube relationship: BFO:0000050 UBERON:0003889 ! part of fallopian tube [Term] id: UBERON:0005049 name: mucosa of infundibulum of uterine tube def: "A mucosa that is part of a uterine tube infundibulum [Automatically generated definition]." [OBOL:automatic] synonym: "mucosa of infundibulum of fallopian tube" EXACT [FMA:18357] synonym: "mucosa of infundibulum of oviduct" EXACT [FMA:18357] synonym: "mucosa of organ of uterine tube infundibulum" EXACT [OBOL:automatic] synonym: "mucosa of uterine tube infundibulum" EXACT [OBOL:automatic] synonym: "mucous membrane of uterine tube infundibulum" EXACT [OBOL:automatic] synonym: "organ mucosa of uterine tube infundibulum" EXACT [OBOL:automatic] synonym: "uterine tube infundibulum mucosa" EXACT [OBOL:automatic] synonym: "uterine tube infundibulum mucosa of organ" EXACT [OBOL:automatic] synonym: "uterine tube infundibulum mucous membrane" EXACT [OBOL:automatic] synonym: "uterine tube infundibulum organ mucosa" EXACT [OBOL:automatic] xref: FMA:18357 is_a: UBERON:0019042 ! reproductive system mucosa intersection_of: UBERON:0000344 ! mucosa intersection_of: BFO:0000050 UBERON:0003984 ! part of uterine tube infundibulum relationship: BFO:0000050 UBERON:0003984 ! part of uterine tube infundibulum [Term] id: UBERON:0005051 name: mediastinum testis def: "The mediastinum testis is a network of fibrous connective tissue that extends from the upper to near the lower extremity of the testis, and is wider above than below. From its front and sides numerous imperfect septa (trabeculæ) are given off, which radiate toward the surface of the organ, and are attached to the tunica albuginea. They divide the interior of the organ into a number of incomplete spaces, called lobules. These are somewhat cone-shaped, being broad at their bases at the surface of the gland, and becoming narrower as they converge to the mediastinum. The mediastinum supports the rete testis and blood vessels of the testis in their passage to and from the substance of the gland[WP]." [Wikipedia:Mediastinum_testis] synonym: "body of highmore" EXACT [FMA:19812] synonym: "hilum of testicle" EXACT [] synonym: "mediastinum of testis" EXACT [FMA:19812] synonym: "testis mediastinum" EXACT [FMA:19812] xref: EMAPA:18331 xref: FMA:19812 xref: MA:0003240 xref: SCTID:362279007 xref: Wikipedia:Mediastinum_testis is_a: UBERON:0002050 ! embryonic structure relationship: BFO:0000050 UBERON:0000473 ! part of testis relationship: BFO:0000051 UBERON:0002384 ! has part connective tissue relationship: RO:0002131 UBERON:0003728 ! overlaps mediastinum property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/b/b5/Hodenschema.svg" xsd:anyURI [Term] id: UBERON:0005055 name: zone of long bone def: "An organ part that is part of a long bone [Automatically generated definition]." [OBOL:automatic] subset: uberon_slim synonym: "long bone zone" EXACT [] xref: FMA:24008 is_a: UBERON:0005913 ! zone of bone organ intersection_of: UBERON:0005913 ! zone of bone organ intersection_of: BFO:0000050 UBERON:0002495 ! part of long bone relationship: BFO:0000050 UBERON:0002495 ! part of long bone [Term] id: UBERON:0005056 name: external female genitalia def: "An external genitalia that is part of a female reproductive system [Automatically generated definition]." [OBOL:automatic] comment: TODO: Relabel. Make distinct organ class. See https://github.com/obophenotype/uberon/issues/547 subset: organ_slim subset: pheno_slim synonym: "external female genital organ" EXACT [BTO:0003100] synonym: "external genitalia of female reproductive system" EXACT [OBOL:automatic] synonym: "female external genitalia" EXACT [FMA:45649] synonym: "organa genitalia feminina externa" RELATED [BTO:0003100] xref: BTO:0003100 xref: EMAPA:30984 xref: FMA:45649 xref: galen:FemaleExternalGenitalia xref: SCTID:362234008 is_a: UBERON:0003134 ! female reproductive organ is_a: UBERON:0004176 ! external genitalia intersection_of: UBERON:0004176 ! external genitalia intersection_of: BFO:0000050 UBERON:0000474 ! part of female reproductive system disjoint_from: UBERON:0009196 ! indifferent external genitalia property_value: RO:0002175 NCBITaxon:50557 property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "external female genitalia" xsd:string [Term] id: UBERON:0005057 name: immune organ def: "An organ that is part of a immune system [Automatically generated definition]." [OBOL:automatic] subset: organ_slim subset: pheno_slim synonym: "immune system organ" EXACT [] is_a: UBERON:0000062 ! organ intersection_of: UBERON:0000062 ! organ intersection_of: BFO:0000050 UBERON:0002405 ! part of immune system relationship: BFO:0000050 UBERON:0002405 ! part of immune system property_value: skos:prefLabel "immune organ" xsd:string [Term] id: UBERON:0005058 name: hemolymphoid system gland def: "A gland that is part of a hemolymphoid system [Automatically generated definition]." [OBOL:automatic] subset: organ_slim synonym: "haemolymphoid system gland" RELATED [EMAPA:18766] synonym: "hemopoietic or lymphoid gland" EXACT [http://orcid.org/0000-0002-6601-2165] synonym: "hemopoietic or lymphoid organ" BROAD [GO:0048534] xref: EMAPA:18766 xref: MA:0002962 is_a: UBERON:0002530 ! gland intersection_of: UBERON:0002530 ! gland intersection_of: BFO:0000050 UBERON:0002193 ! part of hemolymphoid system relationship: BFO:0000050 UBERON:0002193 ! part of hemolymphoid system property_value: skos:prefLabel "hemolymphoid system gland" xsd:string [Term] id: UBERON:0005061 name: neural groove def: "The median dorsal longitudinal groove formed in the embryo by the neural plate after the appearance of the neural folds." [GO:0001842, http://orcid.org/0000-0002-6601-2165, Wikipedia:Neural_groove] xref: AAO:0011071 xref: EMAPA:35594 xref: FMA:295624 xref: NCIT:C34224 xref: neuronames:1363 xref: SCTID:361463007 xref: UMLS:C0814992 {source="ncithesaurus:Neural_Groove"} xref: Wikipedia:Neural_groove xref: XAO:0000248 is_a: UBERON:0002050 ! embryonic structure relationship: BFO:0000050 UBERON:0003075 ! part of neural plate property_value: skos:prefLabel "neural groove" xsd:string [Term] id: UBERON:0005062 name: neural fold def: "One of the two elevated edges of the neural groove[GO,MP]." [GO:0001842, MP:0011256, Wikipedia:Neural_fold] subset: pheno_slim synonym: "medullary fold" EXACT [MP:0011256] xref: EHDAA2:0001249 xref: FMA:295618 xref: NCIT:C34223 xref: neuronames:1364 xref: SCTID:361461009 xref: UMLS:C0814993 {source="ncithesaurus:Neural_Fold"} xref: Wikipedia:Neural_fold xref: XAO:0004087 is_a: UBERON:0002050 ! embryonic structure is_a: UBERON:0005157 ! epithelial fold is_a: UBERON:0005291 ! embryonic tissue is_a: UBERON:0015212 ! lateral structure relationship: BSPO:0000126 UBERON:0005061 ! neural groove property_value: skos:prefLabel "neural fold" xsd:string [Term] id: UBERON:0005064 name: left ventricular trabecular myocardium def: "Missing definition for term UBERON:0005064. Please replace it using linked reference." [GO:0003225] is_a: UBERON:0004126 ! trabecular layer of ventricle intersection_of: UBERON:0004126 ! trabecular layer of ventricle intersection_of: BFO:0000050 UBERON:0002084 ! part of heart left ventricle relationship: BFO:0000050 UBERON:0003382 {source="GO"} ! part of cardiac muscle of left ventricle property_value: skos:prefLabel "left ventricular trabecular myocardium" xsd:string [Term] id: UBERON:0005066 name: right ventricular trabecular myocardium def: "Missing definition for term UBERON:0005066. Please replace it using linked reference." [GO:0003227] is_a: UBERON:0004126 ! trabecular layer of ventricle intersection_of: UBERON:0004126 ! trabecular layer of ventricle intersection_of: BFO:0000050 UBERON:0002080 ! part of heart right ventricle relationship: BFO:0000050 UBERON:0003381 {source="GO"} ! part of cardiac muscle of right ventricle property_value: skos:prefLabel "right ventricular trabecular myocardium" xsd:string [Term] id: UBERON:0005068 name: neural rod def: "A solid rod of neurectoderm derived from the neural keel. The neural rod is roughly circular in cross section. Neural rod formation occurs during primary neurulation in teleosts[GO]. An intermediate stage in the development of the central nervous system present during the segmentation period; the neural rod is roughly cylindrical in shape, forms from the neural keel, and is not yet hollowed out into the neural tube[ZFIN]." [GO:0014024, ZFA:0000133] subset: efo_slim synonym: "neural tube rod" RELATED [GO:0014027] xref: EFO:0003498 xref: TAO:0000133 xref: ZFA:0000133 is_a: UBERON:0016879 ! future central nervous system relationship: RO:0002202 UBERON:0007135 ! develops from neural keel property_value: skos:prefLabel "neural rod" xsd:string [Term] id: UBERON:0005075 name: forebrain-midbrain boundary def: "An anatomical boundary that adjacent_to a forebrain and adjacent_to a midbrain." [OBOL:automatic] synonym: "diencephalic-mesencephalic boundary" EXACT [ZFA:0001367] synonym: "forebrain midbrain boundary" EXACT [ZFA:0001367] synonym: "forebrain-midbrain boundary region" EXACT [EMAPA:36449] xref: EMAPA:36449 xref: TAO:0001367 xref: ZFA:0001367 is_a: BFO:0000002 is_a: UBERON:0007651 ! anatomical junction intersection_of: UBERON:0007651 ! anatomical junction intersection_of: RO:0002220 UBERON:0001890 ! adjacent to forebrain intersection_of: RO:0002220 UBERON:0001891 ! adjacent to midbrain relationship: BFO:0000050 UBERON:0000955 ! part of brain relationship: RO:0002202 UBERON:0007288 {evidence="definitional"} ! develops from presumptive forebrain midbrain boundary relationship: RO:0002220 UBERON:0001890 ! adjacent to forebrain relationship: RO:0002220 UBERON:0001891 ! adjacent to midbrain property_value: skos:prefLabel "forebrain-midbrain boundary" xsd:string [Term] id: UBERON:0005076 name: hindbrain-spinal cord boundary def: "An anatomical boundary that adjacent_to a hindbrain and adjacent_to a spinal cord." [OBOL:automatic] synonym: "hindbrain-spinal cord boundary region" EXACT [] is_a: UBERON:0007651 ! anatomical junction intersection_of: UBERON:0007651 ! anatomical junction intersection_of: RO:0002220 UBERON:0002028 ! adjacent to hindbrain intersection_of: RO:0002220 UBERON:0002240 ! adjacent to spinal cord relationship: BFO:0000050 UBERON:0001017 ! part of central nervous system relationship: RO:0002220 UBERON:0002028 ! adjacent to hindbrain relationship: RO:0002220 UBERON:0002240 ! adjacent to spinal cord property_value: skos:prefLabel "hindbrain-spinal cord boundary" xsd:string [Term] id: UBERON:0005080 name: metanephric ureteric bud def: "The portion of the ureteric bud tube that contributes to the morphogenesis of the metanephros[GO]." [GO:0035502] is_a: UBERON:0000084 ! ureteric bud intersection_of: UBERON:0000084 ! ureteric bud intersection_of: RO:0002387 UBERON:0000081 ! has potential to develop into metanephros relationship: RO:0002387 UBERON:0000081 ! has potential to develop into metanephros [Term] id: UBERON:0005081 name: ureter ureteric bud def: "The portion of the ureteric bud that contributes to the morphogenesis of the ureter. The ureter ureteric bud is the initial structure that forms the ureter[GO]." [GO:0035503] is_a: UBERON:0000084 ! ureteric bud intersection_of: UBERON:0000084 ! ureteric bud intersection_of: RO:0002387 UBERON:0000056 ! has potential to develop into ureter relationship: RO:0002387 UBERON:0000056 ! has potential to develop into ureter [Term] id: UBERON:0005082 name: tube lumen def: "A hole in a tube[GO]." [GO:0060609] xref: AEO:0000078 xref: EHDAA2:0004618 xref: RETIRED_EHDAA2:0003078 is_a: UBERON:0000464 ! anatomical space intersection_of: UBERON:0000464 ! anatomical space intersection_of: RO:0002219 UBERON:0000025 ! surrounded by tube relationship: RO:0002219 UBERON:0000025 ! surrounded by tube property_value: skos:prefLabel "tube lumen" xsd:string [Term] id: UBERON:0005085 name: ectodermal placode def: "An ectodermal placode is a thickening of the ectoderm that is the primordium of many structures derived from the ectoderm[GO]." [GO:0060788] synonym: "epithelial placode" RELATED [AEO:0000112] xref: AEO:0000218 is_a: UBERON:0001048 ! primordium is_a: UBERON:0002050 ! embryonic structure relationship: BFO:0000050 UBERON:0000924 ! part of ectoderm property_value: IAO:0000116 "consder adding placodal ectoderm as a distinct class? Also place placodal ectoderm as develops_from ectoderm; need to check taxon-appropriateness" xsd:string property_value: skos:prefLabel "ectodermal placode" xsd:string [Term] id: UBERON:0005086 name: hair follicle placode def: "A bud-like thickening in the epidermis consisting of elongated keratinocytes, which at the distal end are in touch with numerous aggregated specialized dermal fibroblasts, the dermal condensate." [DOI:10.1016/j.cub.2008.12.005] synonym: "hair gem" RELATED [ISBN:9780878932504] synonym: "hair germ" RELATED [DOI:10.1016/j.cub.2008.12.005] synonym: "hair peg" RELATED [ISBN:9780878932504] synonym: "hair placode" EXACT [DOI:10.1016/j.cub.2008.12.005] synonym: "vibrissa placode" NARROW [] xref: EMAPA:36479 is_a: UBERON:0011817 ! skin appendage placode intersection_of: UBERON:0005085 ! ectodermal placode intersection_of: RO:0002387 UBERON:0002073 ! has potential to develop into hair follicle relationship: RO:0002202 UBERON:0001003 ! develops from skin epidermis relationship: RO:0002202 UBERON:0011272 {source="Wikipathways:WP2062"} ! develops from embryonic skin basal layer relationship: RO:0002387 UBERON:0002073 ! has potential to develop into hair follicle [Term] id: UBERON:0005087 name: tooth placode def: "An tooth placode is a thickening of the ectoderm that will give rise to the tooth bud[GO]." [GO:0060790] synonym: "dental anlage" EXACT [] synonym: "dental placode" EXACT [OBOL:automatic] synonym: "dental primordium" EXACT [ZFA:0001153] synonym: "odontogenic placode" EXACT [OBOL:automatic] synonym: "tooth anlage" EXACT [MP:0000117] synonym: "tooth germ" RELATED [ZFA:0001153] synonym: "tooth primordium" EXACT [MP:0000117] xref: BTO:0001511 xref: TAO:0001153 xref: ZFA:0001153 is_a: BFO:0000002 is_a: UBERON:0006598 ! presumptive structure is_a: UBERON:0011814 {source="NCBIBook:NBK53175"} ! non-neurogenic ectodermal placode intersection_of: UBERON:0005085 ! ectodermal placode intersection_of: RO:0002387 UBERON:0001091 ! has potential to develop into calcareous tooth relationship: RO:0002254 UBERON:0004362 ! has developmental contribution from pharyngeal arch 1 relationship: RO:0002387 UBERON:0001091 ! has potential to develop into calcareous tooth [Term] id: UBERON:0005088 name: sebaceous gland placode def: "A sebaceous gland placode is a thickening of the ectoderm that will give rise to the sebaceous gland bud[GO]." [GO:0060791] is_a: BFO:0000002 is_a: UBERON:0006598 ! presumptive structure is_a: UBERON:0011814 {source="NCBIBook:NBK53175"} ! non-neurogenic ectodermal placode intersection_of: UBERON:0005085 ! ectodermal placode intersection_of: RO:0002387 UBERON:0001821 ! has potential to develop into sebaceous gland relationship: RO:0002202 UBERON:0011272 {source="Wikipathways:WP2062"} ! develops from embryonic skin basal layer relationship: RO:0002387 UBERON:0001821 ! has potential to develop into sebaceous gland property_value: IAO:0000116 "TODO - add bud" xsd:string [Term] id: UBERON:0005089 name: sweat gland placode def: "An sweat gland placode is a thickening of the ectoderm that will give rise to the sweat gland bud[GO]." [GO:0060793] is_a: BFO:0000002 is_a: UBERON:0006598 ! presumptive structure is_a: UBERON:0011814 {source="NCBIBook:NBK53175"} ! non-neurogenic ectodermal placode intersection_of: UBERON:0005085 ! ectodermal placode intersection_of: RO:0002387 UBERON:0001820 ! has potential to develop into sweat gland relationship: RO:0002202 UBERON:0011272 {source="Wikipathways:WP2062"} ! develops from embryonic skin basal layer relationship: RO:0002387 UBERON:0001820 ! has potential to develop into sweat gland property_value: IAO:0000116 "TODO - add bud" xsd:string [Term] id: UBERON:0005090 name: muscle structure def: "Muscle structures are contractile cells, tissues or organs that are found in multicellular organisms[GO]." [GO:0061061] synonym: "muscle" RELATED [] synonym: "muscle element" RELATED [] synonym: "musculus" EXACT [FMA:30316] xref: FMA:30316 is_a: BFO:0000002 is_a: UBERON:0000061 ! anatomical structure relationship: BFO:0000051 CL:0000187 ! has part muscle cell property_value: skos:prefLabel "muscle structure" xsd:string [Term] id: UBERON:0005092 name: right horn of sinus venosus synonym: "sinus venosus right horn" EXACT [VHOG:0000489] xref: EHDAA2:0001841 xref: EHDAA:484 xref: EMAPA:16239 xref: FMA:70318 xref: VHOG:0000489 is_a: UBERON:0002050 {source="FMA"} ! embryonic structure relationship: BSPO:0000121 UBERON:0002063 ! sinus venosus property_value: skos:prefLabel "right horn of sinus venosus" xsd:string [Term] id: UBERON:0005095 name: kidney rudiment def: "Missing definition for term UBERON:0005095. Please replace it using linked reference." [GO:0072003] synonym: "kidney anlage" RELATED [GOC:mtg_kidney_jan10] is_a: BFO:0000002 is_a: UBERON:0002050 ! embryonic structure relationship: RO:0002202 UBERON:0007687 {source="GO"} ! develops from kidney field property_value: IAO:0000116 "class added for consistency with GO - consider merging with kidney mesenchyme." xsd:string [Term] id: UBERON:0005096 name: descending thin limb def: "The descending thin limb is a part of the loop of Henle situated just after the proximal straight tubule (S3). It extends to the tip of the loop of Henle[GO]." [GO:0072022, Wikipedia:Descending_limb_of_loop_of_Henle] subset: human_reference_atlas subset: uberon_slim synonym: "descending limb of Henle's loop" RELATED [Wikipedia:Descending_limb_of_loop_of_Henle] synonym: "descending limb of loop of Henle" RELATED [Wikipedia:Descending_limb_of_loop_of_Henle] synonym: "descending thin limb of loop of Henle" EXACT [] synonym: "loop of Henle descending thin limb" EXACT [] synonym: "loop of Henle thin descending limb" EXACT [MA:0002625] synonym: "pars descendens (tubulus attenuatus)" EXACT [FMA:17719] synonym: "thin descending limb" EXACT [] synonym: "thin descending limb of loop of Henle" RELATED [Wikipedia:Descending_limb_of_loop_of_Henle] synonym: "thin descending limb of the loop of Henle" RELATED [Wikipedia:Descending_limb_of_loop_of_Henle] synonym: "thin descending loop of Henle" RELATED [Wikipedia:Descending_limb_of_loop_of_Henle] xref: EMAPA:35514 xref: FMA:17719 xref: MA:0002625 xref: Wikipedia:Descending_limb_of_loop_of_Henle is_a: UBERON:0000064 ! organ part relationship: BFO:0000050 UBERON:0001289 ! part of descending limb of loop of Henle relationship: BFO:0000050 UBERON:0004136 ! part of intermediate tubule property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/0/02/Gray1128.png" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 property_value: seeAlso "https://github.com/obophenotype/uberon/issues/2276" xsd:string [Term] id: UBERON:0005097 name: renal connecting tubule def: "The connecting tubule is a tubular segment of the nephron; it connects the distal convoluted tubule to the collecting duct[GO]." [GO:0072027, Wikipedia:Connecting_tubule] subset: human_reference_atlas synonym: "connecting tubule" EXACT [MA:0002610] synonym: "kidney connecting tubule" EXACT [MA:0002610] synonym: "tubulus renalis arcuatus" RELATED OMO:0003011 [Wikipedia:Connecting_tubule] xref: BTO:0004539 xref: EMAPA:27758 xref: EMAPA:27790 xref: EMAPA:28011 xref: MA:0002610 xref: Wikipedia:Connecting_tubule is_a: UBERON:0007685 ! region of nephron tubule is_a: UBERON:0012275 ! meso-epithelium relationship: RO:0002202 UBERON:0003220 {source="Wikipedia"} ! develops from metanephric mesenchyme property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/0/02/Gray1128.png" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0005099 name: short descending thin limb def: "The short descending thin limb is the descending thin limb of a short nephron that has a squamous epithelial morphology[GO]." [GO:0072063] subset: human_reference_atlas is_a: UBERON:0004211 ! nephron epithelium is_a: UBERON:0006914 ! squamous epithelium property_value: IAO:0000116 "TODO - epithelium types" xsd:string property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0005100 name: long descending thin limb def: "The long descending limb starts in the inner stripe of the outer medulla and extends into the inner medulla[GO]." [GO:0072064] is_a: UBERON:0004211 ! nephron epithelium [Term] id: UBERON:0005101 name: early distal convoluted tubule def: "The early distal convoluted tubule contains DCT cells and is vasopressin-insensitive[GO]." [GO:0072067] is_a: UBERON:0004211 ! nephron epithelium relationship: BFO:0000050 UBERON:0001292 ! part of distal convoluted tubule [Term] id: UBERON:0005102 name: late distal convoluted tubule def: "The late distal convoluted tubule contains DCT cells and intercalated (IC) alpha and beta cells and is vasopressin-sensitive[GO]." [GO:0072068] is_a: UBERON:0004211 ! nephron epithelium relationship: BFO:0000050 UBERON:0001292 ! part of distal convoluted tubule property_value: IAO:0000116 "TODO - CL" xsd:string [Term] id: UBERON:0005103 name: mesonephric epithelium def: "An epithelium that is part of a mesonephros [Automatically generated definition]." [OBOL:automatic] is_a: UBERON:0004819 ! kidney epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: BFO:0000050 UBERON:0000080 ! part of mesonephros relationship: BFO:0000050 UBERON:0000080 ! part of mesonephros [Term] id: UBERON:0005106 name: metanephric tubule def: "A metanephric tubule is an epithelial tube that is part of the metanephros[GO]." [GO:0072173] xref: VHOG:0001526 is_a: UBERON:0003914 ! epithelial tube is_a: UBERON:0005108 ! metanephric epithelium is_a: UBERON:0006555 ! excretory tube intersection_of: UBERON:0003914 ! epithelial tube intersection_of: BFO:0000050 UBERON:0000081 ! part of metanephros [Term] id: UBERON:0005108 name: metanephric epithelium def: "An epithelium is a tissue that covers the internal or external surfaces of an anatomical structure[GO]." [GO:0072207] is_a: UBERON:0004819 ! kidney epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: BFO:0000050 UBERON:0000081 ! part of metanephros relationship: BFO:0000050 UBERON:0000081 ! part of metanephros [Term] id: UBERON:0005109 name: metanephric smooth muscle tissue def: "Any smooth muscle tissue that is part of a metanephros." [GO:0072208, https://orcid.org/0000-0002-6601-2165] is_a: UBERON:0001135 ! smooth muscle tissue intersection_of: UBERON:0001135 ! smooth muscle tissue intersection_of: BFO:0000050 UBERON:0000081 ! part of metanephros relationship: BFO:0000050 UBERON:0000081 ! part of metanephros [Term] id: UBERON:0005110 name: metanephric nephron def: "A metanephric nephron is the functional unit of the metanephros[GO]." [GO:0072273] xref: VHOG:0000719 is_a: UBERON:0001285 ! nephron is_a: UBERON:0004120 ! mesoderm-derived structure intersection_of: UBERON:0001285 ! nephron intersection_of: BFO:0000050 UBERON:0000081 ! part of metanephros relationship: BFO:0000050 UBERON:0000081 ! part of metanephros relationship: RO:0002495 UBERON:0010535 {source="Bgee:AN"} ! immediate transformation of primitive metanephric nephron [Term] id: UBERON:0005111 name: metanephric pyramid def: "Metanephric pyramids are the conical masses that constitute the renal medulla in a metanephros; they contain the loops of Henle and the medullary collecting ducts[GO]." [GO:0072211] is_a: UBERON:0004200 ! kidney pyramid intersection_of: UBERON:0004200 ! kidney pyramid intersection_of: BFO:0000050 UBERON:0000081 ! part of metanephros relationship: BFO:0000050 UBERON:0000081 ! part of metanephros [Term] id: UBERON:0005113 name: metanephric cortex mesenchyme xref: EHDAA2:0001140 is_a: UBERON:0003104 ! mesenchyme is_a: UBERON:0004120 ! mesoderm-derived structure relationship: RO:0002202 UBERON:0010531 {source="EHDAA2"} ! develops from metanephros induced blastemal cells [Term] id: UBERON:0005114 name: metanephric ascending thin limb def: "The metanephric ascending thin limb is a segment of a nephron tubule in the metanephros lying in the inner medulla that is permeable to ions but not to water and has a simple epithelium; active transepithelial solute transport is absent[GO]." [GO:0072218] is_a: UBERON:0004193 ! loop of Henle ascending limb thin segment is_a: UBERON:0005146 ! metanephric nephron tubule intersection_of: UBERON:0004193 ! loop of Henle ascending limb thin segment intersection_of: BFO:0000050 UBERON:0000081 ! part of metanephros relationship: BFO:0000050 UBERON:0005129 {source="https://github.com/obophenotype/uberon/wiki/Inferring-part-of-relationships"} ! part of metanephric distal tubule [Term] id: UBERON:0005115 name: metanephric cortical collecting duct def: "The metanephric cortical collecting duct is the portion of the metanephric collecting duct that resides in the renal cortex[GO]." [GO:0072219] is_a: UBERON:0004203 ! cortical collecting duct intersection_of: UBERON:0004203 ! cortical collecting duct intersection_of: BFO:0000050 UBERON:0000081 ! part of metanephros relationship: BFO:0000050 UBERON:0004737 {is_inferred="true", source="https://github.com/obophenotype/uberon/wiki/Inferring-part-of-relationships"} ! part of metanephric collecting duct relationship: BFO:0000050 UBERON:0010533 {is_inferred="true", source="https://github.com/obophenotype/uberon/wiki/Inferring-part-of-relationships"} ! part of metanephros cortex [Term] id: UBERON:0005116 name: metanephric descending thin limb def: "It extends to the tip of the metanephric loop of Henle[GO]." [GO:0072220] is_a: UBERON:0005096 ! descending thin limb intersection_of: UBERON:0005096 ! descending thin limb intersection_of: BFO:0000050 UBERON:0000081 ! part of metanephros relationship: BFO:0000050 UBERON:0005130 {is_inferred="true", source="https://github.com/obophenotype/uberon/wiki/Inferring-part-of-relationships"} ! part of metanephric loop of Henle [Term] id: UBERON:0005117 name: metanephric distal convoluted tubule def: "The metanephric distal convoluted tubule is a portion of the metanephric nephron tubule that connects the metanephric loop of Henle to the collecting duct[GO]." [GO:0072221] xref: VHOG:0001569 is_a: UBERON:0001292 ! distal convoluted tubule is_a: UBERON:0005146 ! metanephric nephron tubule intersection_of: UBERON:0001292 ! distal convoluted tubule intersection_of: BFO:0000050 UBERON:0000081 ! part of metanephros relationship: BFO:0000050 UBERON:0010533 {is_inferred="true", source="https://github.com/obophenotype/uberon/wiki/Inferring-part-of-relationships"} ! part of metanephros cortex [Term] id: UBERON:0005118 name: metanephric early distal convoluted tubule def: "The metanephric early distal convoluted tubule contains metanephric DCT cells and is vasopressin-insensitive[GO]." [GO:0072222] is_a: UBERON:0005101 ! early distal convoluted tubule is_a: UBERON:0005134 ! metanephric nephron epithelium intersection_of: UBERON:0005101 ! early distal convoluted tubule intersection_of: BFO:0000050 UBERON:0000081 ! part of metanephros relationship: BFO:0000050 UBERON:0005117 {is_inferred="true", source="https://github.com/obophenotype/uberon/wiki/Inferring-part-of-relationships"} ! part of metanephric distal convoluted tubule relationship: BFO:0000050 UBERON:0005129 {source="https://github.com/obophenotype/uberon/wiki/Inferring-part-of-relationships"} ! part of metanephric distal tubule [Term] id: UBERON:0005119 name: metanephric glomerular mesangium def: "The metanephric glomerular mesangium is the thin membrane connective tissue composed of mesangial cells in the metanephros, which helps to support the capillary loops in a renal glomerulus[GO]." [GO:0072223] is_a: UBERON:0002320 ! glomerular mesangium intersection_of: UBERON:0002320 ! glomerular mesangium intersection_of: BFO:0000050 UBERON:0000081 ! part of metanephros relationship: BFO:0000050 UBERON:0005133 {is_inferred="true", source="https://github.com/obophenotype/uberon/wiki/Inferring-part-of-relationships"} ! part of metanephric glomerulus vasculature [Term] id: UBERON:0005120 name: metanephric late distal convoluted tubule def: "The metanephric late distal convoluted tubule contains metanephric DCT cells and intercalated (IC) alpha and beta cells and is vasopressin-sensitive[GO]." [GO:0072225] is_a: UBERON:0005102 ! late distal convoluted tubule is_a: UBERON:0005134 ! metanephric nephron epithelium intersection_of: UBERON:0005102 ! late distal convoluted tubule intersection_of: BFO:0000050 UBERON:0000081 ! part of metanephros relationship: BFO:0000050 UBERON:0005117 {is_inferred="true", source="https://github.com/obophenotype/uberon/wiki/Inferring-part-of-relationships"} ! part of metanephric distal convoluted tubule relationship: BFO:0000050 UBERON:0005129 {source="https://github.com/obophenotype/uberon/wiki/Inferring-part-of-relationships"} ! part of metanephric distal tubule [Term] id: UBERON:0005122 name: metanephric macula densa def: "The metanephric macula densa is an area of specialized cells in the distal tubule of the metanephros that makes contact with the vascular pole of the glomerulus[GO]." [GO:0072227] is_a: UBERON:0002335 ! macula densa is_a: UBERON:0005134 ! metanephric nephron epithelium intersection_of: UBERON:0002335 ! macula densa intersection_of: BFO:0000050 UBERON:0000081 ! part of metanephros relationship: BFO:0000050 UBERON:0004738 {is_inferred="true", source="https://github.com/obophenotype/uberon/wiki/Inferring-part-of-relationships"} ! part of metanephric juxtaglomerular apparatus [Term] id: UBERON:0005124 name: metanephric proximal convoluted tubule def: "The metanephric proximal convoluted tubule is the most proximal portion of the metanephric proximal tubule and extends from the metanephric glomerular capsule to the metanephric proximal straight tubule[GO]." [GO:0072229] xref: VHOG:0001570 is_a: UBERON:0001287 ! proximal convoluted tubule is_a: UBERON:0005146 ! metanephric nephron tubule intersection_of: UBERON:0001287 ! proximal convoluted tubule intersection_of: BFO:0000050 UBERON:0000081 ! part of metanephros relationship: BFO:0000050 UBERON:0010533 {is_inferred="true", source="https://github.com/obophenotype/uberon/wiki/Inferring-part-of-relationships"} ! part of metanephros cortex [Term] id: UBERON:0005125 name: metanephric proximal straight tubule def: "The metanephric proximal straight tubule is the part of the metanephric descending limb that extends from the metanephric proximal convoluted tubule to the metanephric descending thin tubule[GO]." [GO:0072230] is_a: UBERON:0001290 ! proximal straight tubule is_a: UBERON:0005146 ! metanephric nephron tubule intersection_of: UBERON:0001290 ! proximal straight tubule intersection_of: BFO:0000050 UBERON:0000081 ! part of metanephros relationship: BFO:0000050 UBERON:0005151 {is_inferred="true", source="https://github.com/obophenotype/uberon/wiki/Inferring-part-of-relationships"} ! part of metanephric proximal tubule property_value: IAO:0000116 "TODO - place mammalian xrefs here rather than at parent" xsd:string [Term] id: UBERON:0005126 name: metanephric S1 def: "The S1 portion is the initial portion of the metanephric proximal convoluted tubule and is responsible for avid reabsorption of water and solutes[GO]." [GO:0072231] is_a: UBERON:0004196 ! proximal convoluted tubule segment 1 intersection_of: UBERON:0004196 ! proximal convoluted tubule segment 1 intersection_of: BFO:0000050 UBERON:0000081 ! part of metanephros relationship: BFO:0000050 UBERON:0005124 {is_inferred="true", source="https://github.com/obophenotype/uberon/wiki/Inferring-part-of-relationships"} ! part of metanephric proximal convoluted tubule [Term] id: UBERON:0005127 name: metanephric thick ascending limb def: "At the macula densa, the thick ascending limb connects to the distal convoluted tubule[GO]." [GO:0072233] is_a: UBERON:0001291 ! thick ascending limb of loop of Henle is_a: UBERON:0005146 ! metanephric nephron tubule intersection_of: UBERON:0001291 ! thick ascending limb of loop of Henle intersection_of: BFO:0000050 UBERON:0000081 ! part of metanephros [Term] id: UBERON:0005129 name: metanephric distal tubule def: "The metanephric distal tubule is a metanephric nephron tubule that begins at the metanephric macula densa and extends to the metanephric connecting tubule[GO]." [GO:0072235] is_a: UBERON:0004135 ! distal tubule is_a: UBERON:0005146 ! metanephric nephron tubule intersection_of: UBERON:0004135 ! distal tubule intersection_of: BFO:0000050 UBERON:0000081 ! part of metanephros [Term] id: UBERON:0005130 name: metanephric loop of Henle def: "The metanephric loop of Henle is a metanephric nephron tubule that connects the proximal convoluted tubule to the distal convoluted tubule in the metanephros[GO]." [GO:0072236] is_a: UBERON:0001288 ! loop of Henle is_a: UBERON:0005146 ! metanephric nephron tubule intersection_of: UBERON:0001288 ! loop of Henle intersection_of: BFO:0000050 UBERON:0000081 ! part of metanephros relationship: BFO:0000050 UBERON:0004136 ! part of intermediate tubule [Term] id: UBERON:0005132 name: metanephric long nephron def: "Long nephrons are associated with juxtamedullary glomeruli and extend into the inner medulla in the metanephros[GO]." [GO:0072238] is_a: UBERON:0004194 ! long nephron is_a: UBERON:0005110 ! metanephric nephron intersection_of: UBERON:0004194 ! long nephron intersection_of: BFO:0000050 UBERON:0000081 ! part of metanephros [Term] id: UBERON:0005133 name: metanephric glomerulus vasculature def: "The metanephric glomerulus vasculature is composed of the tubule structures that carry blood or lymph in the metanephric glomerulus[GO]." [GO:0072239] is_a: UBERON:0004190 ! renal glomerulus vasculature intersection_of: UBERON:0004190 ! renal glomerulus vasculature intersection_of: BFO:0000050 UBERON:0000081 ! part of metanephros relationship: BFO:0000050 UBERON:0004736 {is_inferred="true", source="https://github.com/obophenotype/uberon/wiki/Inferring-part-of-relationships"} ! part of metanephric glomerulus [Term] id: UBERON:0005134 name: metanephric nephron epithelium def: "The metanephric nephron epithelium is a tissue that covers the surface of a nephron in the metanephros[GO]." [GO:0072243] is_a: UBERON:0004211 ! nephron epithelium is_a: UBERON:0005108 ! metanephric epithelium intersection_of: UBERON:0004211 ! nephron epithelium intersection_of: BFO:0000050 UBERON:0000081 ! part of metanephros relationship: BFO:0000050 UBERON:0005110 {is_inferred="true", source="https://github.com/obophenotype/uberon/wiki/Inferring-part-of-relationships"} ! part of metanephric nephron [Term] id: UBERON:0005135 name: metanephric glomerular epithelium def: "A metanephric glomerular visceral epithelial cell is a specialized epithelial cell that contains 'feet' that interdigitate with the 'feet' of other glomerular epithelial cells in the metanephros[GO]." [GO:0072244] is_a: UBERON:0004188 ! glomerular epithelium is_a: UBERON:0005134 ! metanephric nephron epithelium intersection_of: UBERON:0004188 ! glomerular epithelium intersection_of: BFO:0000050 UBERON:0000081 ! part of metanephros relationship: BFO:0000050 UBERON:0004736 {is_inferred="true", source="https://github.com/obophenotype/uberon/wiki/Inferring-part-of-relationships"} ! part of metanephric glomerulus [Term] id: UBERON:0005136 name: metanephric glomerular endothelium def: "The metanephric glomerular endothelium is an epithelial tissue that covers the internal surfaces of the glomerulus of the metanephros[GO]." [GO:0072264] is_a: UBERON:0004189 ! glomerular endothelium is_a: UBERON:0005135 ! metanephric glomerular epithelium intersection_of: UBERON:0004189 ! glomerular endothelium intersection_of: BFO:0000050 UBERON:0000081 ! part of metanephros relationship: BFO:0000050 UBERON:0005133 {is_inferred="true", source="https://github.com/obophenotype/uberon/wiki/Inferring-part-of-relationships"} ! part of metanephric glomerulus vasculature [Term] id: UBERON:0005137 name: metanephric capsule def: "The metanephric capsule is the tough fibrous layer surrounding the metanephros, covered in a thick layer of perinephric adipose tissue. It provides some protection from trauma and damage[GO]." [GO:0072213] is_a: UBERON:0002015 ! kidney capsule intersection_of: UBERON:0002015 ! kidney capsule intersection_of: BFO:0000050 UBERON:0000081 ! part of metanephros relationship: BFO:0000050 UBERON:0000081 ! part of metanephros [Term] id: UBERON:0005139 name: metanephric long descending thin limb is_a: UBERON:0005100 ! long descending thin limb is_a: UBERON:0005134 ! metanephric nephron epithelium intersection_of: UBERON:0005100 ! long descending thin limb intersection_of: BFO:0000050 UBERON:0000081 ! part of metanephros [Term] id: UBERON:0005140 name: metanephric short nephron def: "Short nephrons are associated with mid-cortical and superficial glomeruli, are situated entirely in the outer medulla, and have no thin ascending limb[GO]." [GO:0072270] is_a: UBERON:0004195 ! short nephron is_a: UBERON:0005110 ! metanephric nephron intersection_of: UBERON:0004195 ! short nephron intersection_of: BFO:0000050 UBERON:0000081 ! part of metanephros [Term] id: UBERON:0005141 name: metanephric short descending thin limb def: "The metanephric short descending thin limb is the descending thin limb of a short nephron in the metanephros that has a squamous epithelial morphology[GO]." [GO:0072271] is_a: UBERON:0005099 ! short descending thin limb is_a: UBERON:0005134 ! metanephric nephron epithelium intersection_of: UBERON:0005099 ! short descending thin limb intersection_of: BFO:0000050 UBERON:0000081 ! part of metanephros [Term] id: UBERON:0005144 name: metanephric glomerular capillary def: "This process pertains to the initial formation of a structure from unspecified parts[GO]." [GO:0072277] is_a: UBERON:0004212 ! glomerular capillary intersection_of: UBERON:0004212 ! glomerular capillary intersection_of: BFO:0000050 UBERON:0000081 ! part of metanephros relationship: BFO:0000050 UBERON:0004736 {is_inferred="true", source="https://github.com/obophenotype/uberon/wiki/Inferring-part-of-relationships"} ! part of metanephric glomerulus relationship: BFO:0000050 UBERON:0005110 {source="https://github.com/obophenotype/uberon/wiki/Inferring-part-of-relationships"} ! part of metanephric nephron [Term] id: UBERON:0005145 name: metanephric comma-shaped body def: "The metanephric comma-shaped body is the precursor structure to the metanephric S-shaped body that contributes to the morphogenesis of a nephron in the metanephros[GO]." [GO:0072278] is_a: UBERON:0004198 ! comma-shaped body intersection_of: UBERON:0004198 ! comma-shaped body intersection_of: BFO:0000050 UBERON:0000081 ! part of metanephros relationship: BFO:0000050 UBERON:0000081 ! part of metanephros [Term] id: UBERON:0005146 name: metanephric nephron tubule def: "A metanephric nephron tubule is an epithelial tube that is part of the metanephric nephron, the functional part of the metanephros[GO]." [GO:0072282] is_a: UBERON:0001231 ! nephron tubule is_a: UBERON:0005106 ! metanephric tubule is_a: UBERON:0005134 ! metanephric nephron epithelium is_a: UBERON:0012275 ! meso-epithelium intersection_of: UBERON:0001231 ! nephron tubule intersection_of: BFO:0000050 UBERON:0000081 ! part of metanephros relationship: RO:0002202 UBERON:0003220 {source="ISBN:9780878932504"} ! develops from metanephric mesenchyme [Term] id: UBERON:0005147 name: metanephric renal vesicle def: "The renal vesicle is the primordial structure of the metanephric nephron epithelium, and is formed by the condensation of mesenchymal cells[GO]." [GO:0072283] synonym: "metanephric vesicle" EXACT [] xref: EHDAA2:0001245 xref: EHDAA:9346 xref: EMAPA:27678 is_a: UBERON:0004209 ! renal vesicle is_a: UBERON:0005108 ! metanephric epithelium is_a: UBERON:0012275 ! meso-epithelium intersection_of: UBERON:0004209 ! renal vesicle intersection_of: BFO:0000050 UBERON:0000081 ! part of metanephros relationship: RO:0002202 UBERON:0005113 {source="EHDAA2"} ! develops from metanephric cortex mesenchyme relationship: RO:0002387 UBERON:0005134 ! has potential to develop into metanephric nephron epithelium [Term] id: UBERON:0005148 name: metanephric S-shaped body def: "The metanephric S-shaped body is the successor of the metanephric comma-shaped body that contributes to the morphogenesis of a nephron in the metanephros[GO]." [GO:0072284] is_a: UBERON:0004199 ! S-shaped body intersection_of: UBERON:0004199 ! S-shaped body intersection_of: BFO:0000050 UBERON:0000081 ! part of metanephros relationship: BFO:0000050 UBERON:0005110 {is_inferred="true", source="https://github.com/obophenotype/uberon/wiki/Inferring-part-of-relationships"} ! part of metanephric nephron [Term] id: UBERON:0005149 name: metanephric connecting tubule def: "The metanephric connecting tubule is a tubular segment of the metanephric nephron; it connects the distal convoluted tubule to the collecting duct in the metanephros[GO]." [GO:0072286] is_a: UBERON:0005097 ! renal connecting tubule is_a: UBERON:0005146 ! metanephric nephron tubule intersection_of: UBERON:0005097 ! renal connecting tubule intersection_of: BFO:0000050 UBERON:0000081 ! part of metanephros [Term] id: UBERON:0005151 name: metanephric proximal tubule def: "The metanephric proximal tubule is a metanephric nephron tubule that connects Bowman's capsule to the descending thin limb of the loop of Henle in the metanephros. It has a brush border epithelial morphology[GO]." [GO:0072288] is_a: UBERON:0004134 ! proximal tubule is_a: UBERON:0005146 ! metanephric nephron tubule intersection_of: UBERON:0004134 ! proximal tubule intersection_of: BFO:0000050 UBERON:0000081 ! part of metanephros relationship: BFO:0000050 UBERON:0010533 {is_inferred="true", source="https://github.com/obophenotype/uberon/wiki/Inferring-part-of-relationships"} ! part of metanephros cortex [Term] id: UBERON:0005153 name: epithelial bud def: "A bud is a protrusion that forms from an epithelial sheet by localized folding." [GO:0060572] xref: BTO:0001639 is_a: UBERON:0005157 ! epithelial fold property_value: skos:prefLabel "epithelial bud" xsd:string [Term] id: UBERON:0005154 name: epithelial cord def: "A cord of epithelial cells without a lumen and usually several cells thick." [AEO:0000216] xref: AEO:0000216 xref: EHDAA2:0004052 is_a: UBERON:0000486 {source="AEO"} ! multilaminar epithelium [Term] id: UBERON:0005155 name: open tracheal system def: "An open tracheal system is a respiratory system, a branched network of epithelial tubes that supplies oxygen to target tissues via spiracles. An example of this is found in Drosophila melanogaster." [GO:0007424] subset: uberon_slim synonym: "invertebrate tracheal system" EXACT [] synonym: "open tracheal system" EXACT [] synonym: "tracheal system" BROAD SENSU [FBbt:00005024] xref: BTO:0003870 xref: FBbt:00005024 {sssom:mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"} xref: SPD:0000427 xref: TADS:0000043 is_a: UBERON:0001004 ! respiratory system relationship: RO:0002162 NCBITaxon:6656 ! in taxon Arthropoda [Term] id: UBERON:0005156 name: reproductive structure def: "Any anatomical structure that is part of the reproductive system." [http://orcid.org/0000-0002-6601-2165] subset: grouping_class synonym: "reproductive system element" EXACT [] synonym: "reproductive system structure" EXACT [] is_a: UBERON:0010000 ! multicellular anatomical structure intersection_of: UBERON:0010000 ! multicellular anatomical structure intersection_of: BFO:0000050 UBERON:0000990 ! part of reproductive system relationship: BFO:0000050 UBERON:0000990 ! part of reproductive system property_value: skos:prefLabel "reproductive structure" xsd:string [Term] id: UBERON:0005157 name: epithelial fold def: "An epithelial sheet bent on a linear axis." [GO:0060571] is_a: UBERON:0000483 ! epithelium property_value: skos:prefLabel "epithelial fold" xsd:string [Term] id: UBERON:0005158 name: parenchyma of central nervous system def: "The functional tissue of the central nervous system consisting of neurons and glial cells." [CL:tm, https://github.com/obophenotype/uberon/issues/8] synonym: "central nervous system parenchyma" EXACT [OBOL:automatic] synonym: "CNS parenchyma" EXACT [OBOL:automatic] synonym: "parenchyma of central nervous system" EXACT [] synonym: "parenchyma of CNS" EXACT [OBOL:automatic] is_a: UBERON:0000353 ! parenchyma intersection_of: UBERON:0000353 ! parenchyma intersection_of: BFO:0000050 UBERON:0001017 ! part of central nervous system relationship: BFO:0000050 UBERON:0001017 ! part of central nervous system property_value: skos:prefLabel "parenchyma of central nervous system" xsd:string property_value: terms:contributor https://orcid.org/0000-0002-6601-2165 property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 [Term] id: UBERON:0005160 name: vestigial structure def: "A remnant structure from earlier development or evolution." [PATOC:MAH] xref: Wikipedia:Vestigiality is_a: UBERON:0000061 ! anatomical structure intersection_of: UBERON:0000061 ! anatomical structure intersection_of: RO:0000086 PATO:0000588 ! has quality vestigial relationship: RO:0000086 PATO:0000588 ! has quality vestigial [Term] id: UBERON:0005162 name: multi cell part structure def: "A structure consisting mainly of cell components, rather than complete cells." [CARO:0001000] comment: Such a structure may contain some complete cells in addition to partial cells (e.g., glia in nervous system regions). subset: upper_level synonym: "cell part cluster" RELATED [FMA:83115] synonym: "multi-cell-component structure" EXACT [CARO:0001000] synonym: "multi-cell-part structure" EXACT [CARO:0001000] xref: AAO:0011000 xref: CARO:0001000 xref: FBbt:00007060 {sssom:mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"} xref: FMA:83115 is_a: UBERON:0000061 ! anatomical structure relationship: RO:0002473 GO:0005575 ! composed primarily of cellular_component property_value: skos:prefLabel "multi cell part structure" xsd:string [Term] id: UBERON:0005164 name: ascending limb of loop of Henle def: "The distal part of the loop of Henle that is impermeable to water and actively pumps sodium out of the filtrate to generate the hypertonic interstitium that drives countercurrent exchange; it consists of an initial very thin segment lined by simple squamous epithelium followed by a distal thick segment lined by simple cuboidal epithelium[MP]." [MP:0011342, Wikipedia:Ascending_limb_of_loop_of_Henle] subset: pheno_slim subset: uberon_slim synonym: "ascending limb" BROAD [] synonym: "ascending limb of Henle's loop" EXACT [] synonym: "distal straight tubule" RELATED [] synonym: "loop of Henle ascending limb" EXACT [MP:0011342] xref: EMAPA:35510 xref: FMA:17717 xref: MA:0001676 xref: NCIT:C32154 xref: SCTID:245434005 xref: UMLS:C0227658 {source="ncithesaurus:Ascending_Limb_of_the_Henle_s_Loop"} xref: Wikipedia:Ascending_limb_of_loop_of_Henle is_a: UBERON:0004135 ! distal tubule relationship: BFO:0000050 UBERON:0001288 ! part of loop of Henle relationship: RO:0002433 UBERON:0001288 ! contributes to morphology of loop of Henle property_value: IAO:0000116 "TODO - thick/thin check. Also relationship to distal tubule. We need a home for MA:0002634-renal straight tubule" xsd:string [Term] id: UBERON:0005167 name: papillary duct def: "The terminal portions of the medullary collecting ducts are the papillary ducts, which end at the renal papilla and empty into a minor calyx." [http://encyclopedia.thefreedictionary.com/] subset: pheno_slim synonym: "Bellini's duct" RELATED [MP:0011331] synonym: "duct of Bellini" RELATED [] synonym: "papillary duct" EXACT [] synonym: "papillary duct of kidney" EXACT [] synonym: "renal papillary duct" EXACT [] xref: BTO:0004540 xref: EMAPA:35655 xref: MA:0001646 xref: SCTID:110623009 xref: Wikipedia:Duct_of_Bellini is_a: UBERON:0001232 ! collecting duct of renal tubule [Term] id: UBERON:0005168 name: renal interlobular vein def: "Any of the veins that parallel the interlobular arteries, receiving blood from the peritubular capillary plexus and empty into the arcuate veins." [ISBN:0-683-40008-8, MP:0011326] subset: human_reference_atlas subset: pheno_slim synonym: "interlobular vein" EXACT [MA:0002594] synonym: "interlobular veins of kidney" RELATED [FMA:71634] synonym: "set of interlobular veins of kidney" RELATED [FMA:71634] synonym: "venae interlobulares renis" EXACT OMO:0003011 [FMA:71634, FMA:TA] synonym: "venae interlobulares renis" RELATED OMO:0003011 [Wikipedia:Interlobular_veins] xref: EMAPA:28218 xref: FMA:71634 xref: MA:0002594 xref: Wikipedia:Interlobular_veins is_a: UBERON:0013126 ! vein of abdomen is_a: UBERON:0014401 ! renal venous blood vessel disjoint_from: UBERON:0009887 ! interlobar vein relationship: BFO:0000050 UBERON:0001225 ! part of cortex of kidney relationship: RO:0002170 UBERON:0004719 ! connected to kidney arcuate vein property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/0/02/Gray1128.png" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0005169 name: interstitial tissue def: "Connective tissue between the cellular elements of a structure." [http://medical-dictionary.thefreedictionary.com/tissue] subset: human_reference_atlas subset: pheno_slim synonym: "interstitium" EXACT [] xref: FMA:86301 xref: SCTID:85293002 is_a: UBERON:0003891 {source="FMA"} ! stroma property_value: IAO:0000116 "specify differentia from stroma" xsd:string property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0005170 name: granulosa cell layer def: "A layer of the ovarian follicle that consists of granulosa cells." [http://orcid.org/0000-0002-6601-2165] subset: efo_slim subset: human_reference_atlas subset: vertebrate_core synonym: "granulosa cell layer" RELATED [TAO:0001112] synonym: "granulosa cell layer of ovarian follicle" EXACT [FMA:18660] synonym: "granulosa cell layers" RELATED OMO:0003004 [ZFA:0001112] synonym: "membrana granulosa" BROAD [] synonym: "membrana granulosa of ovarian follicle" EXACT [FMA:18660] synonym: "ovary stratum granulosum" EXACT [MA:0001460] synonym: "stratum granulosum of ovarian follicle" EXACT [FMA:18660] xref: EFO:0003628 xref: EMAPA:35633 xref: FMA:18660 xref: MA:0001460 xref: SCTID:258971005 xref: TAO:0001112 xref: Wikipedia:Membrana_granulosa xref: ZFA:0001112 is_a: BFO:0000002 is_a: UBERON:0000119 ! cell layer is_a: UBERON:0005156 ! reproductive structure intersection_of: UBERON:0000119 ! cell layer intersection_of: BFO:0000050 UBERON:0001305 ! part of ovarian follicle intersection_of: RO:0002473 CL:0000501 ! composed primarily of granulosa cell relationship: BFO:0000050 UBERON:0001305 ! part of ovarian follicle relationship: RO:0002473 CL:0000501 ! composed primarily of granulosa cell property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0005171 name: hepatic duct def: "Any portion of the ducts that carry bile from the liver to the common bile duct. This may include both intrahapetic components (parts of left and right hepatic ducts) and extrahapetic components (common hepatic duct, plus hilar portion)." [http://orcid.org/0000-0002-6601-2165] subset: pheno_slim subset: vertebrate_core xref: EHDAA2:0000741 xref: EHDAA:3049 xref: EMAPA:16843 xref: FMA:71891 xref: galen:HepaticDuct xref: MA:0000357 xref: NCIT:C32730 xref: SCTID:245399002 xref: UMLS:C0917710 {source="ncithesaurus:Hepatic_Duct"} xref: VHOG:0000219 is_a: UBERON:0002394 ! bile duct relationship: RO:0002176 UBERON:0001174 ! connects common bile duct relationship: RO:0002176 UBERON:0002107 ! connects liver property_value: IAO:0000116 "TODO - MA distinguishes between bile duct, hepatic duct, common bile duct and common hepatic duct. in FMA hepatic duct and common hepatic duct are the same" xsd:string property_value: skos:prefLabel "hepatic duct" xsd:string [Term] id: UBERON:0005172 name: abdomen element def: "An organ or element that is in the abdomen. Examples: spleen, intestine, kidney, abdominal mammary gland." [http://orcid.org/0000-0002-6601-2165] subset: non_informative synonym: "abdomen organ" EXACT [MA:0000522] xref: MA:0000522 xref: SCTID:272631008 is_a: UBERON:0005173 ! abdominal segment element intersection_of: UBERON:0000062 ! organ intersection_of: BFO:0000050 UBERON:0000916 ! part of abdomen relationship: BFO:0000050 UBERON:0000916 ! part of abdomen property_value: skos:prefLabel "abdomen element" xsd:string [Term] id: UBERON:0005173 name: abdominal segment element def: "An organ or element that is part of the adbominal segment of the organism. This region can be further subdivided into the abdominal cavity and the pelvic region." [http://orcid.org/0000-0002-6601-2165] subset: non_informative synonym: "abdominal segment organ" EXACT [MA:0000529] xref: EMAPA:37062 {source="MA:th"} xref: MA:0000529 is_a: UBERON:0005177 ! trunk region element intersection_of: UBERON:0000062 ! organ intersection_of: BFO:0000050 UBERON:0002417 ! part of abdominal segment of trunk relationship: BFO:0000050 UBERON:0002417 ! part of abdominal segment of trunk property_value: skos:prefLabel "abdominal segment element" xsd:string [Term] id: UBERON:0005174 name: dorsal region element def: "An organ or element that part of the dorsum of the organism. Examples: spinal cord, vertebrae, muscles of back." [http://orcid.org/0000-0002-6601-2165] subset: non_informative synonym: "back organ" EXACT [MA:0001901] synonym: "dorsal region organ" EXACT [] xref: EMAPA:37274 {source="MA:th"} xref: MA:0001901 is_a: UBERON:0000062 ! organ intersection_of: UBERON:0000062 ! organ intersection_of: BFO:0000050 UBERON:0001137 ! part of dorsum relationship: BFO:0000050 UBERON:0001137 ! part of dorsum property_value: skos:prefLabel "dorsal region element" xsd:string [Term] id: UBERON:0005175 name: chest organ def: "An organ that is part of a chest [Automatically generated definition]." [OBOL:automatic] subset: non_informative subset: organ_slim xref: EMAPA:37272 {source="MA:th"} xref: MA:0000552 is_a: UBERON:0005181 ! thoracic segment organ intersection_of: UBERON:0000062 ! organ intersection_of: BFO:0000050 UBERON:0001443 ! part of chest relationship: BFO:0000050 UBERON:0001443 ! part of chest [Term] id: UBERON:0005176 name: tooth enamel organ def: "A circumscribed mass of ectodermal cells which bud off from the dental lamina; it becomes cup-shaped and develops on its internal face the ameloblast layer of cells that produces the enamel cap of a developing tooth." [https://github.com/cerivs/zebrafish-anatomical-ontology/issues/107, https://github.com/obophenotype/uberon/issues/1313, ISBN:0-683-40008-8, MP:0010747, Wikipedia:Enamel_organ] comment: . Alternate definition: A cellular aggregation seen in histologic sections of a developing tooth. It lies above a condensation of ectomesenchymal cells called the odontogenic papilla. subset: pheno_slim subset: vertebrate_core synonym: "dental organ" EXACT [ZFA:0005138] synonym: "enamel organ" EXACT [MP:0010747] synonym: "odontogenic organ" RELATED [] synonym: "organum enameleum" RELATED OMO:0003011 [Wikipedia:Enamel_organ] xref: BTO:0001722 xref: CALOHA:TS-0271 xref: EMAPA:32888 xref: FMA:312389 xref: MA:0001604 xref: MESH:D004658 xref: SCTID:362863002 xref: TAO:0005138 xref: Wikipedia:Enamel_organ xref: ZFA:0005138 is_a: UBERON:0004121 ! ectoderm-derived structure is_a: UBERON:0034922 ! cell cluster relationship: BFO:0000050 UBERON:0008281 ! part of tooth bud property_value: RO:0002161 NCBITaxon:8782 [Term] id: UBERON:0005177 name: trunk region element def: "An organ or element that part of the trunk region. The trunk region can be further subdividied into thoracic (including chest and thoracic cavity) and abdominal (including abdomen and pelbis) regions." [http://orcid.org/0000-0002-6601-2165] subset: non_informative subset: organ_slim synonym: "trunk organ" EXACT [MA:0000516] xref: EMAPA:37270 {source="MA:th"} xref: MA:0000516 is_a: UBERON:0000062 ! organ intersection_of: UBERON:0000062 ! organ intersection_of: BFO:0000050 UBERON:0002100 ! part of trunk relationship: BFO:0000050 UBERON:0002100 ! part of trunk property_value: skos:prefLabel "trunk region element" xsd:string [Term] id: UBERON:0005178 name: thoracic cavity element def: "An organ or element that is in the thoracic cavity. Examples: lung, heart, longus colli." [http://orcid.org/0000-0002-6601-2165] subset: non_informative subset: pheno_slim synonym: "thoracic cavity organ" EXACT [MA:0000557] xref: EMAPA:37273 {source="MA:th"} xref: MA:0000557 is_a: UBERON:0002075 ! viscus is_a: UBERON:0005181 ! thoracic segment organ intersection_of: UBERON:0000062 ! organ intersection_of: RO:0001025 UBERON:0002224 ! located in thoracic cavity relationship: RO:0001025 UBERON:0002224 ! located in thoracic cavity property_value: skos:prefLabel "thoracic cavity element" xsd:string [Term] id: UBERON:0005179 name: pelvic region element def: "An organ or element that is part of the pelvic region. Examples: reproductive organs (in some organisms), urinary bladder, bones of the pelvis." [http://orcid.org/0000-0002-6601-2165] subset: non_informative subset: organ_slim subset: pheno_slim synonym: "pelvic element" EXACT [] synonym: "pelvis organ" EXACT [MA:0000543] synonym: "pelvis region organ" EXACT [] xref: EMAPA:37275 {source="MA:th"} xref: MA:0000543 is_a: UBERON:0005173 ! abdominal segment element intersection_of: UBERON:0000062 ! organ intersection_of: BFO:0000050 UBERON:0002355 ! part of pelvic region of trunk relationship: BFO:0000050 UBERON:0002355 ! part of pelvic region of trunk [Term] id: UBERON:0005181 name: thoracic segment organ def: "An organ that part of the thoracic segment region. This region can be further subdividied chest and thoracic cavity regions." [http://orcid.org/0000-0002-6601-2165] subset: non_informative synonym: "upper body organ" RELATED [MA:0000563] xref: EMAPA:37271 {source="MA:th"} xref: MA:0000563 is_a: UBERON:0005177 ! trunk region element intersection_of: UBERON:0000062 ! organ intersection_of: BFO:0000050 UBERON:0000915 ! part of thoracic segment of trunk relationship: BFO:0000050 UBERON:0000915 ! part of thoracic segment of trunk property_value: skos:prefLabel "thoracic segment organ" xsd:string [Term] id: UBERON:0005184 name: hair medulla def: "Innermost layer of the hair shaft." [Wikipedia:Bone_marrow_of_ovary_(hair)] subset: human_reference_atlas subset: pheno_slim synonym: "medulla of hair shaft" RELATED [BTO:0004671] xref: BTO:0004671 xref: EMAPA:35389 xref: MA:0000158 xref: SCTID:318929009 xref: Wikipedia:Bone_marrow_of_ovary_(hair) is_a: UBERON:0000958 ! medulla of organ intersection_of: UBERON:0000958 ! medulla of organ intersection_of: BFO:0000050 UBERON:0001037 ! part of strand of hair relationship: BFO:0000050 UBERON:0001037 ! part of strand of hair property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0005185 name: renal medulla collecting duct def: "The portion of the collecting duct that resides in the renal medulla." [http://orcid.org/0000-0002-6601-2165] synonym: "kidney medulla collecting duct" EXACT [MA:0002935] synonym: "medullary collecting duct" EXACT [EMAPA:28061] xref: BTO:0004536 xref: EMAPA:28061 xref: EMAPA:35459 xref: MA:0002935 is_a: UBERON:0013522 ! subdivision of tube intersection_of: UBERON:0013522 ! subdivision of tube intersection_of: BFO:0000050 UBERON:0000362 ! part of renal medulla intersection_of: BFO:0000050 UBERON:0001232 ! part of collecting duct of renal tubule relationship: BFO:0000050 UBERON:0000362 ! part of renal medulla relationship: BFO:0000050 UBERON:0001232 ! part of collecting duct of renal tubule [Term] id: UBERON:0005192 name: deferent duct artery def: "An artery in males that provides blood to the vas deferens. The artery usually arises from the anterior trunk of the superior vesical artery. It accompanies the vas deferens into the testis, where it anastomoses with the testicular artery. In this way it also supplies blood to the testis and epididymis. A small branch supplies the ureter[WP]." [Wikipedia:Artery_to_the_ductus_deferens] subset: human_reference_atlas synonym: "arteria ductus deferentis" EXACT OMO:0003011 [Wikipedia:Artery_to_the_ductus_deferens] synonym: "artery of ductus deferens" EXACT [FMA:18930] synonym: "ductus deferens artery" EXACT [FMA:18930] synonym: "vas deferens artery" EXACT [] xref: EMAPA:37513 {source="MA:th"} xref: FMA:18930 xref: MA:0001940 xref: SCTID:279659005 xref: Wikipedia:Artery_to_the_ductus_deferens is_a: UBERON:0001637 ! artery is_a: UBERON:0005156 ! reproductive structure intersection_of: UBERON:0001637 ! artery intersection_of: RO:0020101 UBERON:0001000 ! vessel supplies blood to vas deferens relationship: BFO:0000050 UBERON:0005352 ! part of spermatic cord relationship: RO:0002252 UBERON:0001312 {source="Wikipedia"} ! connecting branch of superior vesical artery relationship: RO:0020101 UBERON:0001000 ! vessel supplies blood to vas deferens property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0005194 name: thoracic vein def: "A vein that is part of a thorax [Automatically generated definition]." [OBOL:automatic] xref: EMAPA:37197 {source="MA:th"} xref: MA:0002235 xref: NCIT:C53142 xref: SCTID:281472008 xref: UMLS:C0226629 {source="ncithesaurus:Thoracic_Vein"} is_a: UBERON:0001638 ! vein is_a: UBERON:0003834 ! thoracic segment blood vessel intersection_of: UBERON:0001638 ! vein intersection_of: BFO:0000050 UBERON:0000915 ! part of thoracic segment of trunk property_value: skos:prefLabel "thoracic vein" xsd:string [Term] id: UBERON:0005195 name: deferent duct vein def: "A vein that is part of a vas deferens [Automatically generated definition]." [OBOL:automatic] xref: EMAPA:37514 {source="MA:th"} xref: MA:0002100 is_a: UBERON:0001638 ! vein is_a: UBERON:0005156 ! reproductive structure intersection_of: UBERON:0001638 ! vein intersection_of: BFO:0000050 UBERON:0001000 ! part of vas deferens relationship: BFO:0000050 UBERON:0001000 ! part of vas deferens [Term] id: UBERON:0005196 name: spleen germinal center def: "A germinal center that is part of the spleen. The spleen germinal center is located in a secondary B follicle in the white pulp of the spleen." [CL:tm, https://github.com/obophenotype/uberon/issues/6] subset: human_reference_atlas subset: pheno_slim synonym: "germinal center of spleen" EXACT [] synonym: "spleen follicle center" EXACT [MP:0008474] synonym: "spleen GC" EXACT [MP:0008474] synonym: "splenic germinal center" EXACT [MP:0008474] xref: EMAPA:35803 xref: MA:0000764 xref: NCIT:C49760 xref: UMLS:C1710156 {source="ncithesaurus:Spleen_Germinal_Center"} is_a: UBERON:0010754 ! germinal center intersection_of: UBERON:0010754 ! germinal center intersection_of: BFO:0000050 UBERON:0002106 ! part of spleen relationship: BFO:0000050 UBERON:0004042 {source="CL:tm"} ! part of spleen secondary B follicle relationship: RO:0002433 UBERON:0004042 ! contributes to morphology of spleen secondary B follicle property_value: RO:0002175 NCBITaxon:9606 property_value: terms:contributor https://orcid.org/0000-0002-6601-2165 property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 [Term] id: UBERON:0005199 name: cervical mammary gland def: "A mammary gland that is part of a cervical region." [OBOL:automatic] xref: MA:0000789 is_a: UBERON:0001911 ! mammary gland intersection_of: UBERON:0001911 ! mammary gland intersection_of: BFO:0000050 UBERON:0005434 ! part of cervical region relationship: BFO:0000050 UBERON:0005434 ! part of cervical region [Term] id: UBERON:0005200 name: thoracic mammary gland def: "A lactiferous gland that is located in the thoracic region/breast." [https://orcid.org/0000-0002-6601-2165, Wikipedia:Mammary_gland#Other_mammals] subset: pheno_slim synonym: "anterior mammary gland" RELATED [Wikipedia:Mammary_gland#Other_mammals] synonym: "breast mammary gland" EXACT [] synonym: "lactiferous gland" BROAD SENSU [FMA:62088] synonym: "mammary gland" BROAD SENSU [FMA:62088] xref: EHDAA2:0001056 xref: EHDAA:6524 xref: EMAPA:36633 xref: FMA:62088 xref: MA:0000797 xref: SCTID:31448001 xref: Wikipedia:Mammary_gland#Other_mammals is_a: UBERON:0001911 ! mammary gland is_a: UBERON:0005175 ! chest organ intersection_of: UBERON:0001911 ! mammary gland intersection_of: BFO:0000050 UBERON:0000915 ! part of thoracic segment of trunk relationship: BFO:0000050 UBERON:0000310 {source="BTO"} ! part of breast [Term] id: UBERON:0005202 name: distal straight tubule macula densa def: "A macula densa that is part of an ascending limb of loop of Henle [Automatically generated definition]." [OBOL:automatic] xref: MA:0002604 is_a: UBERON:0002335 ! macula densa intersection_of: UBERON:0002335 ! macula densa intersection_of: BFO:0000050 UBERON:0001291 ! part of thick ascending limb of loop of Henle relationship: BFO:0000050 UBERON:0001291 {source="MA"} ! part of thick ascending limb of loop of Henle relationship: BFO:0000050 UBERON:0006853 {source="MA"} ! part of renal cortex tubule property_value: IAO:0000116 "TODO - unify terminology - check DST = TAL? Note EMAPA class appears to refer to this segment" xsd:string [Term] id: UBERON:0005203 name: trachea gland def: "A tubuloacinar seromucous gland that is located principally in the submucosa of the trachea. Excretory ducts from this gland pass through the lamina propria to the tracheal lumen." [http://medical-dictionary.thefreedictionary.com/tracheal+glands, https://github.com/obophenotype/uberon/issues/1197, ISBN:1451113412, MGI:Anna, PMID:15973734] subset: human_reference_atlas subset: organ_slim subset: pheno_slim synonym: "glandula trachealis" EXACT [FMA:7473] synonym: "tracheal gland" EXACT [FMA:7473] synonym: "tubular seromucous gland of trachea" RELATED [FMA:7473] xref: EMAPA:36574 xref: FMA:7473 xref: MA:0002937 xref: SCTID:197423006 is_a: UBERON:8410077 ! airway submucosal gland intersection_of: UBERON:0011148 ! submucosal gland intersection_of: BFO:0000050 UBERON:0003126 ! part of trachea intersection_of: BFO:0000051 CL:0000159 ! has part seromucus secreting cell relationship: BFO:0000050 UBERON:0003126 ! part of trachea property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0005204 name: larynx submucosa gland def: "A gland that is part of a larynx submucosa [Automatically generated definition]." [OBOL:automatic] subset: organ_slim synonym: "laryngeal submucosa gland" RELATED [EMAPA:35475] xref: EMAPA:35475 xref: MA:0002729 is_a: UBERON:0036225 ! respiratory system gland intersection_of: UBERON:0002530 ! gland intersection_of: BFO:0000050 UBERON:0004778 ! part of larynx submucosa relationship: BFO:0000050 UBERON:0004778 ! part of larynx submucosa property_value: skos:prefLabel "larynx submucosa gland" xsd:string [Term] id: UBERON:0005205 name: lamina propria of vagina synonym: "vagina stroma" RELATED [MA:0002737] xref: EMAPA:35902 xref: FMA:19979 xref: MA:0002737 is_a: UBERON:0000030 ! lamina propria is_a: UBERON:0005156 ! reproductive structure intersection_of: UBERON:0000030 ! lamina propria intersection_of: BFO:0000050 UBERON:0000996 ! part of vagina relationship: BFO:0000050 UBERON:0000996 ! part of vagina [Term] id: UBERON:0005206 name: choroid plexus stroma def: "Stromal matrix surrounding blood vessels within the choroid plexus." [PMCID:PMC3496674] synonym: "choroid plexus stromal matrix" EXACT [PMCID:PMC3496674] xref: EMAPA:36609 xref: MA:0000825 is_a: BFO:0000002 is_a: UBERON:0003891 ! stroma intersection_of: UBERON:0003891 ! stroma intersection_of: BFO:0000050 UBERON:0001886 ! part of choroid plexus relationship: BFO:0000050 UBERON:0001886 ! part of choroid plexus relationship: BFO:0000051 CL:0000235 ! has part macrophage relationship: BFO:0000051 CL:0000451 ! has part dendritic cell [Term] id: UBERON:0005207 name: tonsil capsule def: "A capsule that is part of a tonsil [Automatically generated definition]." [OBOL:automatic] subset: human_reference_atlas xref: FMA:294647 xref: MA:0000776 is_a: UBERON:0003893 ! capsule intersection_of: UBERON:0003893 ! capsule intersection_of: BFO:0000050 UBERON:0002372 ! part of tonsil relationship: BFO:0000050 UBERON:0002372 ! part of tonsil property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0005208 name: right atrium valve def: "A valve that is part of a right atrium [Automatically generated definition]." [OBOL:automatic] synonym: "right atrium valves" RELATED OMO:0003004 [EHDAA2:0000302] synonym: "superior vena cava valve" RELATED [EMAPA:17327] synonym: "valve of right atrium" EXACT [EMAPA:17327] xref: EHDAA2:0000302 xref: EMAPA:17327 xref: MA:0001871 is_a: UBERON:0003978 ! valve intersection_of: UBERON:0003978 ! valve intersection_of: BFO:0000050 UBERON:0002078 ! part of right cardiac atrium relationship: BFO:0000050 UBERON:0002078 ! part of right cardiac atrium [Term] id: UBERON:0005211 name: renal medulla interstitium def: "Tissue surrounding the loop of Henle in the renal medulla." [Wikipedia:Bone_marrow_of_ovaryry_interstitium] synonym: "kidney medulla interstitium" EXACT [MA:0002619] synonym: "medullary interstitium" NARROW [Wikipedia:Medullary_interstitium] synonym: "medullary stroma" RELATED [EMAPA:18326] synonym: "renal medullary interstitial tissue" EXACT [] synonym: "renal medullary interstitium" EXACT [EMAPA:18326] xref: EMAPA:18326 xref: MA:0002619 xref: SCTID:245693005 xref: Wikipedia:Bone_marrow_of_ovaryry_interstitium is_a: UBERON:0005215 ! kidney interstitium intersection_of: UBERON:0005169 ! interstitial tissue intersection_of: BFO:0000050 UBERON:0000362 ! part of renal medulla relationship: BFO:0000050 UBERON:0000362 ! part of renal medulla relationship: BFO:0000050 UBERON:0005215 {source="MA"} ! part of kidney interstitium relationship: RO:0002216 GO:0070295 ! capable of part of renal water absorption [Term] id: UBERON:0005212 name: Leydig cell region of testis def: "The male gonad containing two functional parts: the SEMINIFEROUS TUBULES for the production and transport of male germ cells (SPERMATOGENESIS) and the interstitial compartment containing LEYDIG CELLS that produce ANDROGENS.." [MESH:A05.360.444.849] subset: pheno_slim synonym: "interstitium of testis" EXACT [https://orcid.org/0000-0002-6601-2165] synonym: "interstitium of the testis" EXACT [EMAPA:18687] synonym: "testis - interstitial" EXACT [https://orcid.org/0000-0002-6601-2165] synonym: "testis interstitial tissue" EXACT [MA:0002713] synonym: "testis interstitium" EXACT [https://orcid.org/0000-0002-6601-2165] xref: EMAPA:18687 xref: MA:0002713 xref: SCTID:362280005 is_a: BFO:0000002 is_a: UBERON:0005156 ! reproductive structure is_a: UBERON:0005169 ! interstitial tissue intersection_of: UBERON:0005169 ! interstitial tissue intersection_of: BFO:0000050 UBERON:0000473 ! part of testis intersection_of: RO:0002473 CL:0000178 ! composed primarily of Leydig cell relationship: BFO:0000050 NCBITaxon:7742 ! part of Vertebrata relationship: BFO:0000050 UBERON:0000473 ! part of testis relationship: RO:0002433 UBERON:0000473 ! contributes to morphology of testis relationship: RO:0002473 CL:0000178 ! composed primarily of Leydig cell [Term] id: UBERON:0005213 name: outer renal medulla interstitium def: "A portion of interstitial tissue that is part of a outer medulla of kidney [Automatically generated definition]." [OBOL:automatic] synonym: "kidney outer medulla interstitium" EXACT [MA:0002621] synonym: "outer medullary interstitium" EXACT [EMAPA:28337] xref: EMAPA:28337 xref: MA:0002621 is_a: UBERON:0005211 ! renal medulla interstitium intersection_of: UBERON:0005169 ! interstitial tissue intersection_of: BFO:0000050 UBERON:0001293 ! part of outer medulla of kidney relationship: BFO:0000050 UBERON:0001293 {source="MA"} ! part of outer medulla of kidney relationship: BFO:0000050 UBERON:0005211 {source="MA"} ! part of renal medulla interstitium [Term] id: UBERON:0005214 name: inner renal medulla interstitium def: "A portion of interstitial tissue that is part of a inner medulla of kidney [Automatically generated definition]." [OBOL:automatic] synonym: "inner medullary interstitium" EXACT [EMAPA:28364] synonym: "kidney inner medulla interstitium" EXACT [MA:0002620] synonym: "papillary interstitium" RELATED [EMAPA:28364] xref: EMAPA:28364 xref: MA:0002620 is_a: UBERON:0005211 ! renal medulla interstitium intersection_of: UBERON:0005169 ! interstitial tissue intersection_of: BFO:0000050 UBERON:0001294 ! part of inner medulla of kidney relationship: BFO:0000050 UBERON:0001294 {source="MA"} ! part of inner medulla of kidney relationship: BFO:0000050 UBERON:0005211 {source="MA"} ! part of renal medulla interstitium [Term] id: UBERON:0005215 name: kidney interstitium def: "The interstitial compartment of the kidney, comprising the extravascular intertubular spaces of the renal parenchyma, with their attendant cellular elements and extracellular substances, bounded on all sides by epithelial and vascular basement membranes." [DOI:10.1038/ki.1991.49, http://orcid.org/0000-0002-6601-2165, PMID:18575881] subset: human_reference_atlas subset: pheno_slim synonym: "interstitial tissue of kidney" EXACT [] synonym: "kidney interstitium group" RELATED [EMAPA:28518] synonym: "renal interstitial tissue" EXACT [] synonym: "renal interstitium" EXACT [FMA:70983] synonym: "renal stroma" EXACT [FMA:70983] synonym: "stroma of kidney" EXACT [FMA:70983] xref: EMAPA:28518 xref: FMA:70983 xref: MA:0002616 xref: NCIT:C33459 xref: SCTID:362210003 is_a: BFO:0000002 is_a: UBERON:0005169 ! interstitial tissue intersection_of: UBERON:0005169 ! interstitial tissue intersection_of: BFO:0000050 UBERON:0002113 ! part of kidney relationship: BFO:0000050 UBERON:0002113 ! part of kidney relationship: RO:0002433 UBERON:0002113 ! contributes to morphology of kidney relationship: RO:0002473 CL:1000692 ! composed primarily of kidney interstitial fibroblast property_value: IAO:0000116 "See https://sourceforge.net/p/geneontology/ontology-requests/10941/" xsd:string property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0005217 name: midbrain subarachnoid space def: "A subarachnoid space that is part of a midbrain [Automatically generated definition]." [OBOL:automatic] synonym: "subarachnoid space mesencephalon" RELATED [VHOG:0001304] synonym: "subarachnoid space midbrain" EXACT [VHOG:0001304] xref: EMAPA:19055 xref: VHOG:0001304 is_a: UBERON:0039175 ! subarachnoid space of brain intersection_of: UBERON:0000315 ! subarachnoid space intersection_of: BFO:0000050 UBERON:0001891 ! part of midbrain relationship: BFO:0000050 UBERON:0001891 ! part of midbrain property_value: skos:prefLabel "midbrain subarachnoid space" xsd:string [Term] id: UBERON:0005218 name: diencephalon subarachnoid space def: "A subarachnoid space that is part of a diencephalon [Automatically generated definition]." [OBOL:automatic] synonym: "subarachnoid space diencephalon" EXACT [VHOG:0001302] xref: EMAPA:19053 xref: VHOG:0001302 is_a: UBERON:0039175 ! subarachnoid space of brain intersection_of: UBERON:0000315 ! subarachnoid space intersection_of: BFO:0000050 UBERON:0001894 ! part of diencephalon relationship: BFO:0000050 UBERON:0001894 ! part of diencephalon property_value: skos:prefLabel "diencephalon subarachnoid space" xsd:string [Term] id: UBERON:0005219 name: hindbrain subarachnoid space def: "A subarachnoid space that is part of a hindbrain [Automatically generated definition]." [OBOL:automatic] synonym: "subarachnoid space hindbrain" EXACT [VHOG:0001303] synonym: "subarachnoid space rhombencephalon" RELATED [VHOG:0001303] xref: EMAPA:18211 xref: VHOG:0001303 is_a: UBERON:0039175 ! subarachnoid space of brain intersection_of: UBERON:0000315 ! subarachnoid space intersection_of: BFO:0000050 UBERON:0002028 ! part of hindbrain relationship: BFO:0000050 UBERON:0002028 ! part of hindbrain property_value: skos:prefLabel "hindbrain subarachnoid space" xsd:string [Term] id: UBERON:0005221 name: liver right lobe parenchyma def: "A parenchyma that is part of a right lobe of liver [Automatically generated definition]." [OBOL:automatic] synonym: "parenchyma of right lobe of liver" EXACT [FMA:71657] xref: EHDAA2:0001010 xref: EMAPA:18317 xref: FMA:71657 xref: VHOG:0000840 is_a: UBERON:0001280 ! liver parenchyma intersection_of: UBERON:0000353 ! parenchyma intersection_of: BFO:0000050 UBERON:0001114 ! part of right lobe of liver relationship: BFO:0000050 UBERON:0001114 ! part of right lobe of liver property_value: skos:prefLabel "liver right lobe parenchyma" xsd:string [Term] id: UBERON:0005222 name: liver left lobe parenchyma def: "A parenchyma that is part of a left lobe of liver [Automatically generated definition]." [OBOL:automatic] synonym: "parenchyma of left lobe of liver" EXACT [FMA:71658] xref: EHDAA2:0001002 xref: EMAPA:18310 xref: FMA:71658 xref: VHOG:0000839 is_a: UBERON:0001280 ! liver parenchyma intersection_of: UBERON:0000353 ! parenchyma intersection_of: BFO:0000050 UBERON:0001115 ! part of left lobe of liver relationship: BFO:0000050 UBERON:0001115 ! part of left lobe of liver property_value: skos:prefLabel "liver left lobe parenchyma" xsd:string [Term] id: UBERON:0005225 name: upper leg epithelium def: "An epithelium that is part of a hindlimb stylopod [Automatically generated definition]." [OBOL:automatic] xref: EHDAA2:0002131 xref: EMAPA:17500 xref: VHOG:0001041 is_a: BFO:0000002 is_a: UBERON:0000483 ! epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: BFO:0000050 UBERON:0000376 ! part of hindlimb stylopod relationship: BFO:0000050 UBERON:0000376 ! part of hindlimb stylopod relationship: RO:0002202 UBERON:0003371 {source="EHDAA2"} ! develops from pelvic appendage bud ectoderm [Term] id: UBERON:0005226 name: pedal digit epithelium def: "An epithelium that is part of a toe [Automatically generated definition]." [OBOL:automatic] synonym: "foot digit epithelium" NARROW SENSU [NCBITaxon:9606, OBOL:accepted] synonym: "hind limb digit epithelium" EXACT [OBOL:accepted] synonym: "toe epithelium" EXACT [] xref: EMAPA:32946 xref: VHOG:0001031 is_a: BFO:0000002 is_a: UBERON:0000490 {source="EHDAA2"} ! unilaminar epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: BFO:0000050 UBERON:0001466 ! part of pedal digit relationship: BFO:0000050 UBERON:0001466 ! part of pedal digit relationship: RO:0002202 UBERON:0003248 {source="EHDAA2"} ! develops from epithelium of footplate [Term] id: UBERON:0005227 name: manual digit epithelium def: "An epithelium that is part of a finger [Automatically generated definition]." [OBOL:automatic] synonym: "finger epithelium" EXACT [] synonym: "fore limb digit epithelium" EXACT [OBOL:accepted] synonym: "hand digit epithelium" NARROW SENSU [NCBITaxon:9606, OBOL:accepted] xref: EHDAA2:0000406 xref: EMAPA:32647 xref: VHOG:0001032 is_a: BFO:0000002 is_a: UBERON:0000490 ! unilaminar epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: BFO:0000050 UBERON:0002389 ! part of manual digit relationship: BFO:0000050 UBERON:0002389 ! part of manual digit relationship: RO:0002202 UBERON:0010332 {source="EHDAA2"} ! develops from epithelium of handplate [Term] id: UBERON:0005228 name: upper arm epithelium def: "An epithelium that is part of a forelimb stylopod [Automatically generated definition]." [OBOL:automatic] xref: EHDAA2:0002113 xref: EMAPA:17425 xref: VHOG:0000990 is_a: BFO:0000002 is_a: UBERON:0000483 ! epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: BFO:0000050 UBERON:0003822 ! part of forelimb stylopod relationship: BFO:0000050 UBERON:0003822 ! part of forelimb stylopod relationship: RO:0002202 UBERON:0003372 {source="EHDAA2"} ! develops from pectoral appendage bud ectoderm [Term] id: UBERON:0005229 name: lower leg epithelium def: "An epithelium that is part of a lower leg [Automatically generated definition]." [OBOL:automatic] xref: EHDAA2:0001031 xref: EMAPA:17497 xref: VHOG:0001050 is_a: BFO:0000002 is_a: UBERON:0000483 ! epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: BFO:0000050 UBERON:0003823 ! part of hindlimb zeugopod relationship: BFO:0000050 UBERON:0003823 ! part of hindlimb zeugopod relationship: RO:0002202 UBERON:0003371 {source="EHDAA2"} ! develops from pelvic appendage bud ectoderm [Term] id: UBERON:0005233 name: medial-nasal process ectoderm def: "An ectoderm that is part of a medial nasal prominence [Automatically generated definition]." [OBOL:automatic] xref: EHDAA2:0001078 xref: EMAPA:16809 xref: FMA:312675 xref: VHOG:0000803 is_a: UBERON:0000924 ! ectoderm is_a: UBERON:0014702 ! frontonasal process epithelium intersection_of: UBERON:0000924 ! ectoderm intersection_of: BFO:0000050 UBERON:0004068 ! part of medial nasal prominence relationship: BFO:0000050 UBERON:0004068 ! part of medial nasal prominence property_value: skos:prefLabel "medial-nasal process ectoderm" xsd:string [Term] id: UBERON:0005234 name: optic eminence ectoderm def: "An ectoderm that is part of a optic eminence [Automatically generated definition]." [OBOL:automatic] xref: EHDAA:940 xref: EMAPA:16539 xref: RETIRED_EHDAA2:0001309 xref: VHOG:0001105 is_a: UBERON:0000924 ! ectoderm intersection_of: UBERON:0000924 ! ectoderm intersection_of: BFO:0000050 UBERON:0004348 ! part of optic eminence relationship: BFO:0000050 UBERON:0004348 ! part of optic eminence property_value: skos:prefLabel "optic eminence ectoderm" xsd:string [Term] id: UBERON:0005239 name: basal plate metencephalon synonym: "metencephalon basal plate" EXACT [EHDAA2:0001154] xref: EHDAA2:0001154 xref: EMAPA:17078 xref: VHOG:0000320 is_a: UBERON:0004064 ! neural tube basal plate property_value: skos:prefLabel "basal plate metencephalon" xsd:string [Term] id: UBERON:0005243 name: interventricular septum endocardium def: "An endocardium that is part of a interventricular septum [Automatically generated definition]." [OBOL:automatic] synonym: "endocardium of interventricular septum" EXACT [FMA:83584] synonym: "interventricular septum endocardial tissue" RELATED [VHOG:0000615] xref: EHDAA2:0000886 xref: EHDAA2:0000887 xref: FMA:83584 xref: VHOG:0000615 is_a: UBERON:0002165 ! endocardium intersection_of: UBERON:0002165 ! endocardium intersection_of: BFO:0000050 UBERON:0002094 ! part of interventricular septum relationship: BFO:0000050 UBERON:0002094 ! part of interventricular septum property_value: IAO:0000116 "TODO - split?" xsd:string property_value: skos:prefLabel "interventricular septum endocardium" xsd:string [Term] id: UBERON:0005248 name: bulbus cordis myocardium def: "A myocardium that is part of a bulbus cordis [Automatically generated definition]." [OBOL:automatic] synonym: "bulbus cordis cardiac muscle" RELATED [VHOG:0000609] xref: EMAPA:36488 xref: VHOG:0000609 is_a: UBERON:0002349 ! myocardium intersection_of: UBERON:0002349 ! myocardium intersection_of: BFO:0000050 UBERON:0004706 ! part of bulbus cordis relationship: BFO:0000050 UBERON:0004706 ! part of bulbus cordis property_value: skos:prefLabel "bulbus cordis myocardium" xsd:string [Term] id: UBERON:0005249 name: metanephric renal pelvis def: "A renal pelvis that is part of a metanephros." [OBOL:automatic] synonym: "metanephros pelvis" EXACT [VHOG:0000945] xref: VHOG:0000945 is_a: UBERON:0001224 ! renal pelvis intersection_of: UBERON:0001224 ! renal pelvis intersection_of: BFO:0000050 UBERON:0000081 ! part of metanephros relationship: BFO:0000050 UBERON:0000081 ! part of metanephros [Term] id: UBERON:0005250 name: stomatodeum gland def: "A gland that is part of a stomodeum." [OBOL:automatic] subset: organ_slim synonym: "stomatodaeum gland" EXACT [VHOG:0000658] xref: VHOG:0000658 is_a: UBERON:0002530 ! gland intersection_of: UBERON:0002530 ! gland intersection_of: BFO:0000050 UBERON:0000930 ! part of stomodeum relationship: BFO:0000050 UBERON:0000930 ! part of stomodeum property_value: IAO:0000116 "check this" xsd:string property_value: skos:prefLabel "stomatodeum gland" xsd:string [Term] id: UBERON:0005251 name: yolk sac cavity def: "An anatomical cavity that is part of a yolk sac [Automatically generated definition]." [OBOL:automatic] synonym: "cavity of yolk sac" EXACT [FMA:63942] synonym: "yolk sac lumen" EXACT [] synonym: "yolk sac space" RELATED [FMA:63942] xref: EMAPA:16055 xref: FMA:63942 xref: VHOG:0000843 is_a: UBERON:0002553 ! anatomical cavity is_a: UBERON:0007473 ! lumen of epithelial sac is_a: UBERON:0012466 ! extraembryonic cavity intersection_of: UBERON:0002553 ! anatomical cavity intersection_of: RO:0002572 UBERON:0001040 ! luminal space of yolk sac relationship: RO:0002572 UBERON:0001040 ! luminal space of yolk sac property_value: skos:prefLabel "yolk sac cavity" xsd:string [Term] id: UBERON:0005253 name: head mesenchyme def: "Portion of primordial embryonic connective tissue of the developing head, consisting of mesenchymal cells supported in interlaminar jelly, that derive mostly from the mesoderm and contribute to head connective tissue, bone and musculature in conjunction with cranial neural crest cells." [ISBN:0683400088, MP:0011260] subset: efo_slim subset: pheno_slim subset: vertebrate_core synonym: "cephalic mesenchyme" EXACT [MP:0011260] synonym: "cranial mesenchyme" RELATED [MGI:anna] synonym: "desmocranium" RELATED PENDING_REVIEW [FMA:76622] xref: EFO:0003492 xref: EHDAA2:0000732 xref: EHDAA:179 xref: EMAPA:16098 xref: EMAPA_RETIRED:16269 xref: FMA:76622 xref: TAO:0000113 xref: VHOG:0000332 xref: ZFA:0000113 is_a: UBERON:0003104 ! mesenchyme is_a: UBERON:0005291 ! embryonic tissue intersection_of: UBERON:0003104 ! mesenchyme intersection_of: BFO:0000050 UBERON:0000033 ! part of head relationship: BFO:0000050 UBERON:0000033 ! part of head relationship: BFO:0000050 UBERON:0009142 {source="EHDAA2"} ! part of entire embryonic mesenchyme property_value: skos:prefLabel "head mesenchyme" xsd:string [Term] id: UBERON:0005254 name: upper leg mesenchyme def: "Mesenchyme that is part of a developing hindlimb stylopod [Automatically generated definition]." [OBOL:automatic] xref: EHDAA2:0002132 xref: EMAPA:17501 xref: VHOG:0000506 is_a: UBERON:0003860 ! hindlimb mesenchyme intersection_of: UBERON:0003104 ! mesenchyme intersection_of: BFO:0000050 UBERON:0000376 ! part of hindlimb stylopod relationship: BFO:0000050 UBERON:0000376 ! part of hindlimb stylopod [Term] id: UBERON:0005255 name: pedal digit mesenchyme def: "Mesenchyme that is part of a developing toe [Automatically generated definition]." [OBOL:automatic] synonym: "finger ray mesenchyme" RELATED [https://orcid.org/0000-0002-6601-2165] synonym: "foot digit mesenchyme" NARROW SENSU [NCBITaxon:9606, OBOL:accepted] synonym: "hind limb digit mesenchyme" EXACT [OBOL:accepted] synonym: "pedal digital ray mesenchyme" RELATED [https://orcid.org/0000-0002-6601-2165] synonym: "toe mesenchyme" EXACT [] xref: EMAPA:32947 xref: VHOG:0000463 is_a: BFO:0000002 is_a: UBERON:0003860 ! hindlimb mesenchyme is_a: UBERON:0010702 ! digit mesenchyme intersection_of: UBERON:0003104 ! mesenchyme intersection_of: BFO:0000050 UBERON:0001466 ! part of pedal digit relationship: BFO:0000050 UBERON:0001466 ! part of pedal digit relationship: RO:0002202 UBERON:0003328 {source="EHDAA2"} ! develops from mesenchyme of footplate [Term] id: UBERON:0005256 name: trunk mesenchyme def: "Mesenchyme that is part of a developing trunk." [OBOL:automatic] subset: efo_slim subset: vertebrate_core synonym: "trunk and cervical mesenchyme" RELATED [EHDAA2:0002092] xref: EFO:0003485 xref: EHDAA2:0002092 xref: EHDAA:377 xref: EMAPA:16177 xref: TAO:0000081 xref: VHOG:0000281 xref: ZFA:0000081 is_a: UBERON:0003104 ! mesenchyme is_a: UBERON:0005291 ! embryonic tissue intersection_of: UBERON:0003104 ! mesenchyme intersection_of: BFO:0000050 UBERON:0000922 ! part of embryo intersection_of: BFO:0000050 UBERON:0002100 ! part of trunk relationship: BFO:0000050 UBERON:0002100 ! part of trunk relationship: BFO:0000050 UBERON:0009142 {source="EHDAA2"} ! part of entire embryonic mesenchyme property_value: skos:prefLabel "trunk mesenchyme" xsd:string [Term] id: UBERON:0005257 name: manual digit mesenchyme def: "Mesenchyme that is part of a developing finger [Automatically generated definition]." [OBOL:automatic] synonym: "anterior limb digital ray mesenchyme" RELATED [https://orcid.org/0000-0002-6601-2165] synonym: "finger mesenchyme" EXACT [] synonym: "finger ray mesenchyme" RELATED [https://orcid.org/0000-0002-6601-2165] synonym: "fore limb digit mesenchyme" EXACT [OBOL:accepted] synonym: "hand digit mesenchyme" NARROW SENSU [NCBITaxon:9606, OBOL:accepted] synonym: "manual digital ray mesenchyme" RELATED [https://orcid.org/0000-0002-6601-2165] xref: EHDAA2:0000407 xref: EMAPA:32645 xref: VHOG:0001416 is_a: BFO:0000002 is_a: UBERON:0003859 ! forelimb mesenchyme is_a: UBERON:0010702 ! digit mesenchyme intersection_of: UBERON:0003104 ! mesenchyme intersection_of: BFO:0000050 UBERON:0002389 ! part of manual digit relationship: BFO:0000050 UBERON:0002389 ! part of manual digit relationship: RO:0002202 UBERON:0009523 ! develops from mesenchyme of handplate property_value: IAO:0000116 "In EHDAA2, the metacarpal cartilage condensation is considered part of the digits - it might be better to call the whole structure digital ray mesenchyme/condensation" xsd:string [Term] id: UBERON:0005258 name: upper arm mesenchyme def: "Mesenchyme that is part of a developing forelimb stylopod [Automatically generated definition]." [OBOL:automatic] xref: EHDAA2:0002114 xref: EMAPA:17426 xref: VHOG:0000505 is_a: UBERON:0003859 ! forelimb mesenchyme intersection_of: UBERON:0003104 ! mesenchyme intersection_of: BFO:0000050 UBERON:0003822 ! part of forelimb stylopod relationship: BFO:0000050 UBERON:0003822 ! part of forelimb stylopod [Term] id: UBERON:0005259 name: lower leg mesenchyme def: "Mesenchyme that is part of a developing lower leg [Automatically generated definition]." [OBOL:automatic] xref: EHDAA2:0001032 xref: EMAPA:17498 xref: VHOG:0000752 is_a: UBERON:0003860 ! hindlimb mesenchyme intersection_of: UBERON:0003104 ! mesenchyme intersection_of: BFO:0000050 UBERON:0003823 ! part of hindlimb zeugopod relationship: BFO:0000050 UBERON:0003823 ! part of hindlimb zeugopod [Term] id: UBERON:0005268 name: renal cortex artery def: "An artery that supplies the renal cortex." [http://orcid.org/0000-0002-6601-2165] subset: pheno_slim synonym: "kidney cortex artery" EXACT [MP:0011314] synonym: "renal cortex arterial system" RELATED [MA:0002582] synonym: "renal cortex artery" EXACT [MA:0002582] xref: EMAPA:28147 xref: MA:0002582 is_a: UBERON:0001637 ! artery is_a: UBERON:0003644 ! kidney arterial blood vessel intersection_of: UBERON:0001637 ! artery intersection_of: RO:0020101 UBERON:0001225 ! vessel supplies blood to cortex of kidney relationship: BFO:0000050 UBERON:0001225 {source="MA"} ! part of cortex of kidney relationship: RO:0002433 UBERON:0001225 ! contributes to morphology of cortex of kidney relationship: RO:0020101 UBERON:0001225 ! vessel supplies blood to cortex of kidney [Term] id: UBERON:0005269 name: renal cortex vein def: "Artery that receives blood from the renal cortex[MP, modified]." [MGI:csmith] subset: pheno_slim synonym: "kidney cortex vein" RELATED [MP:0011322] synonym: "renal cortex venous system" RELATED [MA:0002592] xref: EMAPA:28152 xref: MA:0002592 is_a: UBERON:0013126 ! vein of abdomen is_a: UBERON:0014401 ! renal venous blood vessel intersection_of: UBERON:0001638 ! vein intersection_of: RO:0020102 UBERON:0001225 ! vessel drains blood from cortex of kidney relationship: BFO:0000050 UBERON:0001225 {source="MA"} ! part of cortex of kidney relationship: RO:0002433 UBERON:0001225 ! contributes to morphology of cortex of kidney relationship: RO:0020102 UBERON:0001225 ! vessel drains blood from cortex of kidney [Term] id: UBERON:0005270 name: renal cortex interstitium def: "A compartment of the renal cortex situated between basement membranes of epithelia and vessels that contains two contiguous cellular networks in mutual contact, one formed by interstitial fibroblasts, the other by dendritic cells." [PMID:18575881] synonym: "cortical stroma" RELATED [EMAPA:28136] synonym: "kidney cortex interstitium" EXACT [MA:0002608] synonym: "renal cortical interstitial tissue" EXACT [] xref: EMAPA:28136 xref: MA:0002608 xref: SCTID:243707006 xref: Wikipedia:Medullary_interstitium is_a: UBERON:0005215 ! kidney interstitium intersection_of: UBERON:0005169 ! interstitial tissue intersection_of: BFO:0000050 UBERON:0001225 ! part of cortex of kidney relationship: BFO:0000050 UBERON:0001225 {source="MA"} ! part of cortex of kidney relationship: BFO:0000050 UBERON:0005215 {source="MA"} ! part of kidney interstitium relationship: BFO:0000051 CL:0000451 ! has part dendritic cell [Term] id: UBERON:0005271 name: juxtamedullary cortex def: "The part of the renal cortex nearest to the medulla." [http://medical-dictionary.thefreedictionary.com/juxtamedullary+cortex] subset: human_reference_atlas synonym: "inner cortex of kidney" EXACT [FMA:74288] synonym: "inner renal cortex" EXACT [KUPO:0001008] synonym: "juxtamedullary cortex of kidney" EXACT [FMA:74288] xref: EMAPA:37623 {source="MA:th"} xref: FMA:74288 xref: KUPO:0001008 xref: MA:0001648 is_a: UBERON:0000064 ! organ part relationship: BFO:0000050 UBERON:0001225 {source="FMA", source="KUPO"} ! part of cortex of kidney property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0005272 name: peritubular capillary def: "The tiny blood vessels that receive blood from the efferent arterioles of the glomerulus, and interact with superficial cortical nephrons allowing reabsorption and secretion between blood and the inner lumen of the nephron; peritubular capillaries are situated around the tubule and are at low pressure." [MGI:csmith, MP:0011321] subset: human_reference_atlas subset: pheno_slim xref: EMAPA:36558 xref: MA:0002588 xref: Wikipedia:Peritubular_capillaries is_a: UBERON:0003527 ! kidney capillary relationship: RO:0002170 UBERON:0004640 ! connected to renal efferent arteriole relationship: RO:0002216 GO:0070293 {source="Wikipedia"} ! capable of part of renal absorption property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0005273 name: nail bed def: "Region of skin beneath the nail plate[WP]." [UBERON:gvg] subset: pheno_slim synonym: "nailbed" EXACT [] xref: EMAPA:35581 xref: EV:0100158 xref: MA:0002706 xref: SCTID:181578005 xref: VHOG:0001362 is_a: UBERON:0005275 ! dorsal skin of digit relationship: BFO:0000050 UBERON:0004105 ! part of subungual region relationship: RO:0002220 UBERON:0008198 ! adjacent to nail plate relationship: RO:0002433 UBERON:0001705 ! contributes to morphology of nail [Term] id: UBERON:0005275 name: dorsal skin of digit synonym: "dorsal digit skin" EXACT [] synonym: "skin of dorsal part of digit" EXACT [] is_a: UBERON:0015249 ! digit skin [Term] id: UBERON:0005276 name: dorsal skin of finger def: "A dorsal skin of digit that is part of a manual digit." [OBOL:automatic] synonym: "dorsal finger skin" EXACT [] synonym: "skin of dorsal part of finger" EXACT [FMA:38320] synonym: "subdivision of skin of dorsal part of finger" EXACT [FMA:60346] xref: FMA:38320 xref: FMA:60346 is_a: UBERON:0003533 ! manual digit skin is_a: UBERON:0005275 ! dorsal skin of digit intersection_of: UBERON:0005275 ! dorsal skin of digit intersection_of: BFO:0000050 UBERON:0002389 ! part of manual digit [Term] id: UBERON:0005277 name: dorsal skin of toe def: "A dorsal skin of digit that is part of a pedal digit." [OBOL:automatic] synonym: "dorsal toe skin" EXACT [] synonym: "skin of dorsal part of toe" EXACT [FMA:37868] synonym: "subdivision of skin of dorsal part of toe" EXACT [FMA:60523] xref: FMA:37868 xref: FMA:60523 is_a: UBERON:0003530 ! pedal digit skin is_a: UBERON:0005275 ! dorsal skin of digit intersection_of: UBERON:0005275 ! dorsal skin of digit intersection_of: BFO:0000050 UBERON:0001466 ! part of pedal digit [Term] id: UBERON:0005278 name: nail bed of finger def: "A nail bed that is part of a manual digit." [OBOL:automatic] synonym: "nail bed of finger" EXACT [FMA:60348] xref: FMA:60348 xref: SCTID:244199003 is_a: UBERON:0005273 ! nail bed is_a: UBERON:0005276 ! dorsal skin of finger intersection_of: UBERON:0005273 ! nail bed intersection_of: BFO:0000050 UBERON:0002102 ! part of forelimb [Term] id: UBERON:0005279 name: nail bed of toe def: "A nail bed that is part of a pedal digit." [OBOL:automatic] synonym: "nail bed of toe" EXACT [FMA:60529] xref: FMA:60529 xref: SCTID:244200000 is_a: UBERON:0005273 ! nail bed is_a: UBERON:0005277 ! dorsal skin of toe intersection_of: UBERON:0005273 ! nail bed intersection_of: BFO:0000050 UBERON:0002103 ! part of hindlimb [Term] id: UBERON:0005281 name: ventricular system of central nervous system def: "A set of structures containing cerebrospinal fluid in the brain. It is continuous with the central canal of the spinal cord[WP]." [Wikipedia:Ventricular_system] subset: efo_slim subset: vertebrate_core synonym: "CNS ventricular system" EXACT [EHDAA2:0004362] synonym: "ventricle system" RELATED [Wikipedia:Ventricular_system] synonym: "ventricular system" EXACT [ZFA:0001261] synonym: "ventricular system of neuraxis" EXACT [FMA:242675] synonym: "ventriculi cerebri" RELATED OMO:0003011 [Wikipedia:Ventricular_system] xref: EFO:0003650 xref: EHDAA2:0004362 xref: EV:0100306 xref: FMA:242675 xref: MBA:73 xref: neuronames:2497 xref: TAO:0001261 xref: Wikipedia:Ventricular_system xref: ZFA:0001261 is_a: UBERON:0000467 {source="ZFA"} ! anatomical system relationship: BFO:0000050 UBERON:0001017 ! part of central nervous system property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/7/7d/Gray734.png" xsd:anyURI property_value: IAO:0000116 "TODO - resolve space vs structure conflation. We follow FMA in making this and the various ventricles a structure - it follows from this that strutures such as the tela choroidea and choroid plexuses can be part of the ventricles and ventricular system. Note: see also the class 'neuraxis cavity'" xsd:string property_value: skos:prefLabel "ventricular system of central nervous system" xsd:string [Term] id: UBERON:0005282 name: ventricular system of brain synonym: "brain ventricular system" EXACT [VHOG:0000005] xref: CALOHA:TS-1295 xref: EMAPA:37447 {source="MA:th"} xref: FMA:242787 xref: VHOG:0000005 is_a: UBERON:0000467 ! anatomical system relationship: BFO:0000050 UBERON:0000955 ! part of brain relationship: BFO:0000050 UBERON:0005281 ! part of ventricular system of central nervous system property_value: skos:prefLabel "ventricular system of brain" xsd:string [Term] id: UBERON:0005283 name: tela choroidea def: "A structure found in the walls of the ventricles of the brain, consisting of part of the meninges (pia mater in mammals) plus ependyma[cjm]." [http://isc.temple.edu/neuroanatomy/lab/embryo_new/choroid/, ISBN:0471888893, Wikipedia:Tela_chorioidea] subset: pheno_slim subset: vertebrate_core synonym: "tela chorioidea" RELATED [FMA:242849] xref: FMA:242849 xref: neuronames:1378 xref: TAO:0000447 xref: Wikipedia:Tela_chorioidea xref: ZFA:0000447 is_a: UBERON:0004923 ! organ component layer relationship: BFO:0000050 UBERON:0005358 {source="FMA"} ! part of ventricle of nervous system relationship: RO:0002131 UBERON:0001886 ! overlaps choroid plexus relationship: RO:0002131 UBERON:0010743 ! overlaps meningeal cluster property_value: skos:prefLabel "tela choroidea" xsd:string [Term] id: UBERON:0005287 name: tela choroidea of fourth ventricle def: "Tela chorioidea that lines the fourth ventricle[ZFA]. The tela chorioidea of the fourth ventricle is the name applied to the triangular fold of pia mater which is carried upward between the cerebellum and the medulla oblongata. It consists of two layers, which are continuous with each other in front, and are more or less adherent throughout: The posterior layer covers the antero-inferior surface of the cerebellum. The anterior layer is applied to the structures which form the lower part of the roof of the ventricle, and is continuous inferiorly with the pia mater on the inferior peduncles and closed part of the medulla[WP]." [Wikipedia:Tela_chorioidea_of_fourth_ventricle, ZFIN:curator] subset: vertebrate_core synonym: "choroid membrane" EXACT [FMA:78493] synonym: "choroid membrane of fourth ventricle" EXACT [FMA:78493] synonym: "tela chorioidea fourth ventricle" EXACT [] synonym: "tela choroidea" BROAD [FMA:78493, FMA:TA] synonym: "tela choroidea fourth ventricle" EXACT [] synonym: "tela choroidea of fourth ventricle" EXACT [] synonym: "tela choroidea ventriculi quarti" EXACT OMO:0003011 [FMA:78493, FMA:TA] synonym: "tela choroidea ventriculi quarti" RELATED OMO:0003011 [Wikipedia:Tela_chorioidea_of_fourth_ventricle] xref: BAMS:tc4v xref: FMA:78493 xref: neuronames:639 xref: SCTID:362321009 xref: TAO:0005158 xref: Wikipedia:Tela_chorioidea_of_fourth_ventricle xref: ZFA:0005158 is_a: UBERON:0005283 ! tela choroidea intersection_of: UBERON:0005283 ! tela choroidea intersection_of: BFO:0000050 UBERON:0002422 ! part of fourth ventricle relationship: BFO:0000050 UBERON:0002422 ! part of fourth ventricle property_value: skos:prefLabel "tela choroidea of fourth ventricle" xsd:string [Term] id: UBERON:0005288 name: tela choroidea of third ventricle def: "Tela chorioidea that lines the third ventricle[ZFA]. The part of the choroid plexus in relation to the body of the ventricle forms the vascular fringed margin of a triangular process of pia mater, named the tela chorioidea of the third ventricle, and projects from under cover of the lateral edge of the fornix. Blood is supplied by branches from the superior cerebellar artery[WP]." [Wikipedia:Tela_chorioidea_of_third_ventricle, ZFIN:curator] subset: vertebrate_core synonym: "choroid membrane of third ventricle" EXACT [FMA:78463] synonym: "tela chorioidea of third ventricle" EXACT [] synonym: "tela chorioidea third ventricle" EXACT [ZFA:0005159] synonym: "tela choroidea third ventricle" EXACT [] synonym: "tela choroidea ventriculi tertii" EXACT OMO:0003011 [FMA:78463, FMA:TA] synonym: "tela choroidea ventriculi tertii" RELATED OMO:0003011 [Wikipedia:Tela_chorioidea_of_third_ventricle] xref: BAMS:tc3v xref: FMA:78463 xref: neuronames:453 xref: SCTID:362320005 xref: TAO:0005159 xref: Wikipedia:Tela_chorioidea_of_third_ventricle xref: ZFA:0005159 is_a: UBERON:0005283 ! tela choroidea intersection_of: UBERON:0005283 ! tela choroidea intersection_of: BFO:0000050 UBERON:0002286 ! part of third ventricle relationship: BFO:0000050 UBERON:0002286 ! part of third ventricle property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/6/60/Gray723.png" xsd:anyURI property_value: skos:prefLabel "tela choroidea of third ventricle" xsd:string [Term] id: UBERON:0005289 name: tela choroidea of telencephalic ventricle def: "Tela chorioidea that lines the telencephalic ventricle." [ZFIN:curator] subset: vertebrate_core synonym: "tela chorioidea of lateral ventricle" EXACT [] synonym: "tela chorioidea of telencephalic ventricle" EXACT [] synonym: "tela chorioidea telencephalic ventricle" EXACT [ZFA:0005160] synonym: "tela choroidea (ventriculi lateralis)" EXACT OMO:0003011 [FMA:83712, FMA:TA] synonym: "tela choroidea of lateral ventricle" EXACT [FMA:83712] synonym: "tela choroidea telencephalic ventricle" EXACT [] xref: BAMS:tclv xref: FMA:83712 xref: neuronames:219 xref: SCTID:362319004 xref: TAO:0005160 xref: ZFA:0005160 is_a: UBERON:0005283 ! tela choroidea intersection_of: UBERON:0005283 ! tela choroidea intersection_of: BFO:0000050 UBERON:0002285 ! part of telencephalic ventricle relationship: BFO:0000050 UBERON:0002285 ! part of telencephalic ventricle property_value: skos:prefLabel "tela choroidea of telencephalic ventricle" xsd:string [Term] id: UBERON:0005290 name: myelencephalon def: "The posterior part of the developing vertebrate hindbrain or the corresponding part of the adult brain composed of the medulla oblongata and a portion of the fourth ventricle; as well as the glossopharyngeal nerve (CN IX), vagus nerve (CN X), accessory nerve (CN XI), hypoglossal nerve (CN XII), and a portion of the vestibulocochlear nerve (CN VIII).[BTO,WP]." [BTO:0000758, Wikipedia:Myelencephalon] subset: uberon_slim synonym: "myelencephalon (medulla oblongata)" RELATED [DHBA:10662] xref: BTO:0000758 xref: CALOHA:TS-0607 xref: CALOHA:TS-2365 xref: DHBA:10662 xref: EHDAA2:0001207 xref: EHDAA:5526 xref: EMAPA:17082 xref: HBA:9512 xref: MA:0000205 xref: VHOG:0000456 xref: Wikipedia:Myelencephalon is_a: UBERON:0004121 ! ectoderm-derived structure is_a: UBERON:0004733 ! segmental subdivision of hindbrain relationship: RO:0002495 UBERON:0010096 {evidence="definitional"} ! immediate transformation of future myelencephalon property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/5/54/EmbryonicBrain.svg" xsd:anyURI property_value: skos:prefLabel "myelencephalon" xsd:string [Term] id: UBERON:0005291 name: embryonic tissue def: "A portion of tissue that is part of an embryo." [OBOL:automatic] subset: pheno_slim subset: upper_level synonym: "developing tissue" RELATED [] synonym: "portion of embryonic tissue" EXACT [OBOL:automatic] xref: CALOHA:TS-2100 is_a: UBERON:0000479 ! tissue intersection_of: UBERON:0000479 ! tissue intersection_of: BFO:0000050 UBERON:0000922 ! part of embryo relationship: BFO:0000050 UBERON:0002050 ! part of embryonic structure property_value: skos:prefLabel "embryonic tissue" xsd:string [Term] id: UBERON:0005292 name: extraembryonic tissue def: "Portion of tissue that is contiguous with the embryo and is comprised of portions of tissue or cells that will not contribute to the embryo." [https://orcid.org/0000-0002-6601-2165] subset: efo_slim synonym: "extra-embryonic tissue" EXACT [] xref: BTO:0003360 xref: CALOHA:TS-2119 xref: EFO:0001406 xref: MAT:0000061 xref: MIAA:0000061 is_a: UBERON:0000479 ! tissue intersection_of: UBERON:0000479 ! tissue intersection_of: BFO:0000050 UBERON:0016887 ! part of entire extraembryonic component relationship: BFO:0000050 UBERON:0016887 ! part of entire extraembryonic component property_value: skos:prefLabel "extraembryonic tissue" xsd:string [Term] id: UBERON:0005293 name: cerebellum lobe def: "A major subdivision of the cerebellum: anterior, posterior and flocculonodular." [Wikipedia:Anatomy_of_the_cerebellum#Gross_anatomical_divisions] synonym: "cerebellar lobe" EXACT [FMA:242392] synonym: "cerebellar lobes" RELATED [BAMS:CBl] synonym: "lobe of cerebellum" EXACT [FMA:242392] synonym: "lobe parts of the cerebellar cortex" EXACT [BIRNLEX:1076] xref: BAMS:CBl xref: BIRNLEX:1076 xref: EMAPA:35220 xref: FMA:242392 xref: MA:0002963 xref: SCTID:263971006 is_a: UBERON:0002749 ! regional part of cerebellar cortex property_value: skos:prefLabel "cerebellum lobe" xsd:string [Term] id: UBERON:0005294 name: gonadal ridge def: "The elevation of thickened mesothelium and underlying mesenchyme found on the ventromedial border of the embryonic mesonephros in which the primordial germ cells become embedded, establishing it as the primordium of the testis or ovary." [MGI:anna, MP:0011411] subset: efo_slim subset: pheno_slim synonym: "crista gonadalis" RELATED OMO:0003011 [Wikipedia:Gonadal_ridge] synonym: "genital cord" RELATED [MP:0011411] synonym: "genital ridge" EXACT [MP:0011411, Wikipedia:Gonadal_ridge] synonym: "gonadal ridge" EXACT [Wikipedia:Gonadal_ridge] synonym: "indifferent gonadal ridge" EXACT [http://orcid.org/0000-0002-6601-2165] xref: AAO:0011047 xref: BTO:0001402 xref: EFO:0001414 xref: EHDAA2:0004044 xref: EMAPA:35899 xref: FMA:321917 xref: NCIT:C34184 xref: NCIT:C34321 xref: SCTID:308801004 xref: SCTID:361399001 xref: UMLS:C0231047 {source="ncithesaurus:Urogenital_Ridge"} xref: UMLS:C1512243 {source="ncithesaurus:Gonadal_Ridge"} xref: Wikipedia:Gonadal_ridge xref: XAO:0000018 is_a: BFO:0000002 is_a: UBERON:0002050 ! embryonic structure relationship: BFO:0000050 UBERON:0004122 ! part of genitourinary system relationship: RO:0002202 UBERON:0004876 ! develops from urogenital fold property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/3/30/Gray1106.png" xsd:anyURI property_value: IAO:0000116 "TODO - check developmental relationships. merge with urogenital ridge?" xsd:string [Term] id: UBERON:0005295 name: sex cord def: "Cordlike masses of epithelial tissue that invaginate from germinal epithelium of the gonad and give rise to seminiferous tubules and rete testes in the male, and primary ovarian follicles and rete ovarii in the female." [http://www.answers.com/topic/sex-cord, Wikipedia:Sex_cords] synonym: "genital cord" RELATED [] synonym: "gonad cord" RELATED [] synonym: "gonadal cord" RELATED [] synonym: "primitive sex cord" RELATED [] xref: NCIT:C34183 xref: RETIRED_EHDAA2:0001523 xref: SCTID:343823004 xref: UMLS:C1512242 {source="ncithesaurus:Gonadal_Cord"} xref: Wikipedia:Sex_cords is_a: UBERON:0005154 {source="EHDAA2"} ! epithelial cord is_a: UBERON:0005291 ! embryonic tissue is_a: UBERON:0012275 ! meso-epithelium relationship: RO:0002202 UBERON:0005294 ! develops from gonadal ridge [Term] id: UBERON:0005296 name: ovary sex cord def: "Structures that develop from sex cords in the female. After further development they become the ovarian follicles." [Wikipedia:Cortical_cords] synonym: "cortical cord" RELATED [] synonym: "cortical sex cord" RELATED [] synonym: "ovary primitive sex cord" RELATED [] synonym: "ovigerous cord" EXACT [] synonym: "ovigerous cords" EXACT OMO:0003004 [VHOG:0001339] synonym: "secondary cord" RELATED [] xref: EHDAA2:0001363 xref: EHDAA:8130 xref: EMAPA:31058 xref: NCIT:C34134 xref: UMLS:C1511527 {source="ncithesaurus:Cortical_Cord"} xref: VHOG:0001339 xref: Wikipedia:Cortical_cords is_a: UBERON:0004911 ! epithelium of female gonad is_a: UBERON:0005295 ! sex cord intersection_of: UBERON:0005295 ! sex cord intersection_of: BFO:0000050 UBERON:0000992 ! part of ovary relationship: RO:0002202 UBERON:0010141 ! develops from primitive sex cord of indifferent gonad property_value: IAO:0000116 "TODO check secondary vs cortical vs ovary" xsd:string [Term] id: UBERON:0005297 name: testis sex cord def: "The testis cords are precursors to the rete testis. They play several different roles in the development of the male genitals[WP]." [Wikipedia:Testis_cords] subset: pheno_slim synonym: "primary sex cord" RELATED [] synonym: "testis cord" EXACT [MP:0006424] synonym: "testis primary sex cords" EXACT [EHDAA2:0002011] synonym: "testis primitive sex cord" RELATED [] xref: EHDAA2:0002011 xref: EHDAA:8152 xref: EMAPA:29098 xref: VHOG:0001321 xref: Wikipedia:Testis_cords is_a: UBERON:0004910 ! epithelium of male gonad is_a: UBERON:0005295 ! sex cord intersection_of: UBERON:0005295 ! sex cord intersection_of: BFO:0000050 UBERON:0000473 ! part of testis relationship: RO:0002495 UBERON:0010141 {source="Bgee:AN"} ! immediate transformation of primitive sex cord of indifferent gonad property_value: IAO:0000116 "TODO - check primary vs testis" xsd:string [Term] id: UBERON:0005298 name: skin of clitoris def: "A zone of skin that is part of a clitoris [Automatically generated definition]." [OBOL:automatic] synonym: "clitoris skin" EXACT [] xref: FMA:20168 xref: SCTID:361374002 is_a: UBERON:8480029 ! skin of external genitalia intersection_of: UBERON:0000014 ! zone of skin intersection_of: BFO:0000050 UBERON:0002411 ! part of clitoris relationship: BFO:0000050 UBERON:0002411 ! part of clitoris [Term] id: UBERON:0005299 name: prepuce of clitoris def: "A retractable double-layered fold of skin and mucous membrane that covers the clitoral glans." [http://orcid.org/0000-0002-6601-2165, Wikipedia:Clitoral_hood] synonym: "clitoral hood" EXACT [Wikipedia:Clitoral_hood] synonym: "clitoral prepuce" EXACT [] synonym: "clitoris prepuce" EXACT [] synonym: "prepuce of female" EXACT [EMAPA:30699] synonym: "prepuce of the clitoris" EXACT [] synonym: "preputium clitoridis" EXACT [Wikipedia:Clitoral_hood] xref: EMAPA:30699 xref: FMA:20169 xref: NCIT:C32590 xref: SCTID:362242009 xref: UMLS:C0227771 {source="ncithesaurus:Female_Prepuce"} xref: Wikipedia:Clitoral_hood is_a: UBERON:0011374 ! prepuce intersection_of: UBERON:0011374 ! prepuce intersection_of: BFO:0000050 UBERON:0002411 ! part of clitoris relationship: BFO:0000050 UBERON:0002411 ! part of clitoris relationship: RO:0002220 UBERON:0006653 ! adjacent to glans clitoris relationship: RO:0002494 UBERON:0035006 ! transformation of preputial swelling of female property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/b/bd/Clitoris_outer_anatomy.gif" xsd:anyURI [Term] id: UBERON:0005305 name: thyroid follicle def: "Discrete, cystlike units of the thyroid gland that are lined with cuboidal epithelium and are filled with a colloid substance, about 30 to each lobule[BTO]." [BTO:0004708] subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "thyroid follicles" RELATED OMO:0003004 [ZFA:0001072] synonym: "thyroid gland follicle" EXACT [] xref: BTO:0004708 xref: EMAPA:19307 xref: EMAPA:19308 xref: FMA:68805 xref: MA:0000726 xref: NCIT:C33782 xref: SCTID:176685006 xref: TAO:0001072 xref: UMLS:C0229577 {source="ncithesaurus:Thyroid_Gland_Follicle"} xref: ZFA:0001072 is_a: UBERON:0000064 ! organ part relationship: BFO:0000050 UBERON:0002046 ! part of thyroid gland relationship: RO:0002433 UBERON:0002046 ! contributes to morphology of thyroid gland [Term] id: UBERON:0005309 name: pronephric nephron def: "A pronephric nephron is the functional unit of the pronephros[GO]." [GO:0039019] xref: AAO:0011091 xref: XAO:0000285 is_a: UBERON:0001285 ! nephron intersection_of: UBERON:0001285 ! nephron intersection_of: BFO:0000050 UBERON:0002120 ! part of pronephros relationship: BFO:0000050 UBERON:0002120 ! part of pronephros [Term] id: UBERON:0005310 name: pronephric nephron tubule def: "The pronephric nephron tubule is an epithelial tube that is part of the pronephric nephron and connects the filtration unit (glomerulus or glomus) of the pronephros to the pronephric duct[GO]." [GO:0039020] synonym: "ciliated neck segment" RELATED [ZFA:0001558] synonym: "pronephric tubule" EXACT [ZFA:0001558] xref: TAO:0001558 xref: XAO:0004105 xref: ZFA:0001558 is_a: UBERON:0001231 ! nephron tubule intersection_of: UBERON:0001231 ! nephron tubule intersection_of: BFO:0000050 UBERON:0005309 ! part of pronephric nephron relationship: BFO:0000050 UBERON:0005309 {source="GO"} ! part of pronephric nephron [Term] id: UBERON:0005311 name: mammary placode def: "The mammary placode is a transient lens shaped structure that will give rise to the mammary bud proper[GO]." [GO:0060596] synonym: "mammary anlage" RELATED [] xref: EMAPA:35541 is_a: BFO:0000002 is_a: UBERON:0011814 {source="NCBIBook:NBK53175"} ! non-neurogenic ectodermal placode relationship: BFO:0000050 UBERON:0000076 {source="PMID:20484386"} ! part of external ectoderm relationship: RO:0002202 UBERON:0008425 {source="Stedmans"} ! develops from mammary ridge property_value: IAO:0000116 "TODO develops_from" xsd:string [Term] id: UBERON:0005316 name: endocardial endothelium def: "The endothelial lining of the endocardium." [UBERON:cjm] synonym: "endocardium endothelium" EXACT [FMA:83596] synonym: "endothelium of endocardium" EXACT [FMA:83596] xref: FMA:83596 is_a: UBERON:0008307 ! heart endothelium intersection_of: UBERON:0001986 ! endothelium intersection_of: BFO:0000050 UBERON:0002165 ! part of endocardium relationship: BFO:0000050 UBERON:0002165 ! part of endocardium property_value: skos:prefLabel "endocardial endothelium" xsd:string [Term] id: UBERON:0005317 name: pulmonary artery endothelium def: "An pulmonary artery endothelium is an epithelium that lines the pulmonary artery[GO]." [GO:0061155] synonym: "pulmonary artery endothelial tube" EXACT [GO:0061155] xref: BTO:0000137 is_a: UBERON:0001917 ! endothelium of artery intersection_of: UBERON:0001986 ! endothelium intersection_of: BFO:0000050 UBERON:0002012 ! part of pulmonary artery relationship: BFO:0000050 UBERON:0002012 ! part of pulmonary artery property_value: skos:prefLabel "pulmonary artery endothelium" xsd:string [Term] id: UBERON:0005319 name: mesonephric collecting duct def: "The collecting duct is the final common path through which urine flows before entering the ureter and then emptying into the bladder[GO]." [GO:0061211] xref: AAO:0010390 xref: XAO:0000151 is_a: UBERON:0001232 ! collecting duct of renal tubule intersection_of: UBERON:0001232 ! collecting duct of renal tubule intersection_of: BFO:0000050 UBERON:0000080 ! part of mesonephros relationship: BFO:0000050 UBERON:0005322 {is_inferred="true", source="https://github.com/obophenotype/uberon/wiki/Inferring-part-of-relationships"} ! part of mesonephric nephron [Term] id: UBERON:0005320 name: mesonephric juxtaglomerular apparatus def: "The juxtaglomerular apparatus lies adjacent to the glomerulus and regulates kidney function by maintaining the blood flow to the kidney and the filtration rate[GO]." [GO:0061212] is_a: UBERON:0002303 ! juxtaglomerular apparatus intersection_of: UBERON:0002303 ! juxtaglomerular apparatus intersection_of: BFO:0000050 UBERON:0000080 ! part of mesonephros relationship: BFO:0000050 UBERON:0000080 ! part of mesonephros [Term] id: UBERON:0005321 name: mesonephric smooth muscle tissue def: "Missing definition for term UBERON:0005321. Please replace it using linked reference." [GO:0061214] is_a: UBERON:0001135 ! smooth muscle tissue intersection_of: UBERON:0001135 ! smooth muscle tissue intersection_of: BFO:0000050 UBERON:0000080 ! part of mesonephros relationship: BFO:0000050 UBERON:0000080 ! part of mesonephros [Term] id: UBERON:0005322 name: mesonephric nephron def: "A nephron that is part of a mesonephros." [http://orcid.org/0000-0002-6601-2165] synonym: "nephron of mesonephros" EXACT [] synonym: "stage IV nephron" RELATED [ZFA:0005592] xref: AAO:0010387 xref: XAO:0000292 xref: ZFA:0005592 is_a: UBERON:0001285 ! nephron intersection_of: UBERON:0001285 ! nephron intersection_of: BFO:0000050 UBERON:0000080 ! part of mesonephros relationship: BFO:0000050 UBERON:0000080 ! part of mesonephros relationship: RO:0002202 UBERON:0005323 {source="XAO"} ! develops from mesonephric mesenchyme [Term] id: UBERON:0005323 name: mesonephric mesenchyme def: "Mesonephric mesenchyme is the tissue made up of loosely connected mesenchymal cells in the mesonephros[GO]." [GO:0061219] subset: pheno_slim xref: AAO:0011062 xref: EHDAA2:0001132 xref: EMAPA:16745 xref: XAO:0000291 is_a: UBERON:0003104 ! mesenchyme intersection_of: UBERON:0003104 ! mesenchyme intersection_of: BFO:0000050 UBERON:0000080 ! part of mesonephros relationship: BFO:0000050 UBERON:0000080 ! part of mesonephros [Term] id: UBERON:0005324 name: mesonephric macula densa def: "The mesonephric macula densa is an area of specialized cells in the distal tubule of the mesonephros that makes contact with the vascular pole of the glomerulus[GO]." [GO:0061220] is_a: UBERON:0002335 ! macula densa is_a: UBERON:0005330 ! mesonephric nephron epithelium intersection_of: UBERON:0002335 ! macula densa intersection_of: BFO:0000050 UBERON:0000080 ! part of mesonephros relationship: BFO:0000050 UBERON:0005320 {is_inferred="true", source="https://github.com/obophenotype/uberon/wiki/Inferring-part-of-relationships"} ! part of mesonephric juxtaglomerular apparatus [Term] id: UBERON:0005325 name: mesonephric glomerulus def: "The mesonephric glomerulus is a capillary tuft which forms a close network with the visceral epithelium (podocytes) and the mesangium to form the filtration barrier and is surrounded by Bowman's capsule in nephrons of the mature vertebrate kidney, or mesonephros[GO]." [GO:0061224] synonym: "glomerulus" BROAD SENSU [AAO:0010388] xref: AAO:0010388 xref: EMAPA:30568 xref: VHOG:0001238 xref: XAO:0000146 is_a: UBERON:0000074 ! renal glomerulus intersection_of: UBERON:0000074 ! renal glomerulus intersection_of: BFO:0000050 UBERON:0000080 ! part of mesonephros relationship: BFO:0000050 UBERON:0000080 ! part of mesonephros [Term] id: UBERON:0005326 name: mesonephric glomerulus vasculature def: "The mesonephric glomerulus vasculature is composed of the tubule structures that carry blood or lymph in the mesonephric glomerulus[GO]." [GO:0061231] is_a: UBERON:0004190 ! renal glomerulus vasculature intersection_of: UBERON:0004190 ! renal glomerulus vasculature intersection_of: BFO:0000050 UBERON:0000080 ! part of mesonephros relationship: BFO:0000050 UBERON:0005325 {is_inferred="true", source="https://github.com/obophenotype/uberon/wiki/Inferring-part-of-relationships"} ! part of mesonephric glomerulus [Term] id: UBERON:0005327 name: mesonephric glomerular epithelium def: "A mesonephric glomerular visceral epithelial cell is a specialized epithelial cell that contains 'feet' that interdigitate with the 'feet' of other glomerular epithelial cells in the mesonephros[GO]." [GO:0061232] is_a: UBERON:0004188 ! glomerular epithelium is_a: UBERON:0005330 ! mesonephric nephron epithelium intersection_of: UBERON:0004188 ! glomerular epithelium intersection_of: BFO:0000050 UBERON:0000080 ! part of mesonephros relationship: BFO:0000050 UBERON:0005325 {is_inferred="true", source="https://github.com/obophenotype/uberon/wiki/Inferring-part-of-relationships"} ! part of mesonephric glomerulus [Term] id: UBERON:0005328 name: mesonephric comma-shaped body def: "The mesonephric comma-shaped body is the precursor structure to the mesonephric S-shaped body that contributes to the morphogenesis of a nephron in the mesonephros[GO]." [GO:0061236] is_a: UBERON:0004198 ! comma-shaped body intersection_of: UBERON:0004198 ! comma-shaped body intersection_of: BFO:0000050 UBERON:0000080 ! part of mesonephros relationship: BFO:0000050 UBERON:0000080 ! part of mesonephros [Term] id: UBERON:0005329 name: mesonephric nephron tubule def: "A mesonephric nephron tubule is an epithelial tube that is part of the mesonephric nephron, the functional part of the mesonephros[GO]." [GO:0061240] synonym: "mesonephric renal tubule" EXACT [https://orcid.org/0000-0002-6601-2165] is_a: UBERON:0000083 ! mesonephric tubule is_a: UBERON:0001231 ! nephron tubule is_a: UBERON:0005330 ! mesonephric nephron epithelium [Term] id: UBERON:0005330 name: mesonephric nephron epithelium def: "The mesonephric nephron epithelium is a tissue that covers the surface of a nephron in the mesonephros[GO]." [GO:0061241] is_a: UBERON:0004211 ! nephron epithelium is_a: UBERON:0005103 ! mesonephric epithelium intersection_of: UBERON:0004211 ! nephron epithelium intersection_of: BFO:0000050 UBERON:0000080 ! part of mesonephros relationship: BFO:0000050 UBERON:0005322 {is_inferred="true", source="https://github.com/obophenotype/uberon/wiki/Inferring-part-of-relationships"} ! part of mesonephric nephron [Term] id: UBERON:0005331 name: mesonephric renal vesicle def: "The renal vesicle is the primordial structure of the mesonephric nephron epithelium, and is formed by the condensation of mesenchymal cells[GO]." [GO:0061243] synonym: "mesonephric vesicle" EXACT [] xref: SCTID:361407006 xref: ZFA:0005586 is_a: UBERON:0004209 ! renal vesicle is_a: UBERON:0005103 ! mesonephric epithelium intersection_of: UBERON:0004209 ! renal vesicle intersection_of: BFO:0000050 UBERON:0000080 ! part of mesonephros relationship: RO:0002202 UBERON:0010534 {source="ZFA"} ! develops from primitive mesonephric nephron relationship: RO:0002387 UBERON:0005330 ! has potential to develop into mesonephric nephron epithelium [Term] id: UBERON:0005332 name: mesonephric S-shaped body def: "The mesonephric S-shaped body is the successor of the mesonephric comma-shaped body that contributes to the morphogenesis of a nephron in the mesonephros[GO]." [GO:0061244] is_a: UBERON:0004199 ! S-shaped body intersection_of: UBERON:0004199 ! S-shaped body intersection_of: BFO:0000050 UBERON:0000080 ! part of mesonephros relationship: BFO:0000050 UBERON:0000080 ! part of mesonephros [Term] id: UBERON:0005333 name: mammary bud def: "A bulb of epithelial cells that forms from the mammary placode that develops into the mammary gland." [http://orcid.org/0000-0002-6601-2165] synonym: "lactiferous gland bud" EXACT [] synonym: "mammary gland bud" EXACT [GO:0060648] synonym: "mammary primordium" RELATED [] synonym: "milk bud" RELATED [] xref: EMAPA:35536 is_a: UBERON:0005153 ! epithelial bud is_a: UBERON:0010371 ! ecto-epithelium intersection_of: UBERON:0005153 ! epithelial bud intersection_of: RO:0002494 UBERON:0005311 ! transformation of mammary placode relationship: RO:0002494 UBERON:0005311 ! transformation of mammary placode [Term] id: UBERON:0005334 name: oral lamina propria def: "A lamina propria that is part of a mucosa of oral region." [OBOL:automatic] synonym: "lamina propria of oral mucosa" EXACT [] xref: EMAPA:26947 is_a: UBERON:0000030 ! lamina propria intersection_of: UBERON:0000030 ! lamina propria intersection_of: BFO:0000050 UBERON:0003343 ! part of mucosa of oral region relationship: BFO:0000050 UBERON:0003343 ! part of mucosa of oral region property_value: skos:prefLabel "oral lamina propria" xsd:string [Term] id: UBERON:0005337 name: outflow tract of ventricle def: "A ventricular outflow tract is a portion of either the left ventricle or right ventricle of the heart through which blood passes in order to enter the great arteries. The right ventricular outflow tract (RVOT) is an infundibular extension of the ventricular cavity which connects to the pulmonary artery. The left ventricular outflow tract (LVOT), which connects to the aorta, is nearly indistinguishable from the rest of the ventricle[WP]." [Wikipedia:Ventricular_outflow_tract] synonym: "heart ventricle outflow tract" EXACT [MP:0010224] synonym: "outflow part of ventricle" EXACT [] synonym: "ventricular outflow tract" EXACT [Wikipedia:Ventricular_outflow_tract] xref: FMA:13225 xref: Wikipedia:Ventricular_outflow_tract xref: XAO:0004140 is_a: UBERON:0004145 ! outflow tract intersection_of: UBERON:0004145 ! outflow tract intersection_of: BFO:0000050 UBERON:0002082 ! part of cardiac ventricle relationship: BFO:0000050 UBERON:0002082 ! part of cardiac ventricle property_value: skos:prefLabel "outflow tract of ventricle" xsd:string [Term] id: UBERON:0005338 name: outflow tract aortic component def: "An outflow tract that is part of a aorta." [OBOL:automatic] xref: EHDAA2:0001353 xref: EMAPA:17329 xref: MA:0000101 xref: VHOG:0001394 is_a: UBERON:0004145 ! outflow tract intersection_of: UBERON:0004145 ! outflow tract intersection_of: BFO:0000050 UBERON:0000947 ! part of aorta relationship: BFO:0000050 UBERON:0000947 ! part of aorta property_value: IAO:0000116 "merge with LVOT?" xsd:string property_value: skos:prefLabel "outflow tract aortic component" xsd:string [Term] id: UBERON:0005339 name: outflow tract pulmonary component xref: EHDAA2:0001359 xref: EHDAA:4401 xref: EMAPA:17330 xref: MA:0000102 xref: VHOG:0001395 is_a: UBERON:0004145 ! outflow tract property_value: IAO:0000116 "merge with RVOT?" xsd:string property_value: skos:prefLabel "outflow tract pulmonary component" xsd:string [Term] id: UBERON:0005340 name: dorsal telencephalic commissure def: "A fiber tracts that connect the dorsal region of the two cerebral hemispheres and span the longitudinal fissure, including the corpus callosum and hippocampal commissure[MP]." [MP:0008219] subset: pheno_slim synonym: "dorsal commissure" EXACT [MP:0008219] xref: EMAPA:37844 {source="MA:th"} xref: NLX:147892 is_a: UBERON:0019294 ! commissure of telencephalon relationship: RO:0002176 UBERON:0000203 ! connects pallium property_value: skos:prefLabel "dorsal telencephalic commissure" xsd:string [Term] id: UBERON:0005343 name: cortical plate def: "The outer neural tube region in which post-mitotic neuroblasts migrate along radial glia to form the adult cortical layers[MP]." [http://www.ncbi.nlm.nih.gov/books/NBK10047, MP:0008439] subset: pheno_slim synonym: "cerebral cortex cortical plate" EXACT [] synonym: "CP" BROAD OMO:0003000 [BRAINSPAN:BRAINSPAN] synonym: "CxP" BROAD OMO:0003000 [PMID:23375746] synonym: "future cortical layers II-VI" EXACT [http://orcid.org/0000-0002-6601-2165] synonym: "future neocortex" RELATED [http://orcid.org/0000-0002-6601-2165] synonym: "neocortex cortical plate" EXACT [] xref: BAMS:CTXpl xref: DHBA:10515 xref: EMAPA:32711 xref: MBA:695 xref: MESH:D002540 {sssom:mapping_justification="https://w3id.org/semapv/vocab/LexicalMatching"} xref: neuronames:2702 xref: PBA:294021914 is_a: UBERON:0014950 ! layer of developing cerebral cortex relationship: RO:0002387 UBERON:0001950 {source="NCBIBook:NBK10047"} ! has potential to develop into neocortex property_value: skos:prefLabel "cortical plate" xsd:string [Term] id: UBERON:0005351 name: paraflocculus subset: pheno_slim synonym: "cerebellar tonsil" EXACT [NLXANAT:20081212] synonym: "hemispheric lobule IX" RELATED INCONSISTENT [NLXANAT:20081212] synonym: "neuraxis paraflocculus" EXACT [FMA:83885] synonym: "parafloccular lobule of cerebellum" EXACT [ISBN:0123813611] synonym: "paraflocculus of cerebellum" EXACT [FMA:83885] synonym: "tonsil (HXI)" EXACT [NLXANAT:20081212] synonym: "tonsilla" EXACT [NLXANAT:20081212] xref: BAMS:CbT xref: BAMS:PFL xref: BAMS:PFl xref: DMBA:16945 xref: EMAPA:37402 {source="MA:th"} xref: FMA:278790 xref: FMA:83885 xref: MBA:1041 xref: neuronames:672 xref: NLXANAT:20081212 xref: SCTID:314174005 xref: SCTID:51969002 xref: Wikipedia:Cerebellar_tonsil is_a: UBERON:0004003 ! cerebellum hemisphere lobule is_a: UBERON:0027331 ! flocculonodular lobe, hemisphere portion property_value: IAO:0000116 "consider separate class for IX." xsd:string property_value: skos:prefLabel "paraflocculus" xsd:string [Term] id: UBERON:0005352 name: spermatic cord def: "The cord-like structure in males comprising the vas deferens and associated tissue that runs from the abdomen down to each testis[MP]." [MP:0010145, Wikipedia:Spermatic_cord] subset: pheno_slim synonym: "funiculus spermaticus" RELATED OMO:0003011 [Wikipedia:Spermatic_cord] synonym: "spermatic chord" RELATED [] xref: FMA:19937 xref: GAID:395 xref: MESH:D013085 xref: NCIT:C12329 xref: SCTID:181433005 xref: UMLS:C0037855 {source="ncithesaurus:Spermatic_Cord"} xref: Wikipedia:Spermatic_cord is_a: UBERON:0005156 ! reproductive structure is_a: UBERON:0034921 ! multi organ part structure relationship: BFO:0000050 UBERON:0004054 ! part of internal male genitalia relationship: BFO:0000051 UBERON:0001000 ! has part vas deferens relationship: RO:0002433 UBERON:0004054 ! contributes to morphology of internal male genitalia property_value: foaf:depiction "https://upload.wikimedia.org/wikipedia/commons/3/35/Male_anatomy.png" xsd:anyURI [Term] id: UBERON:0005356 name: Rathke's pouch def: "A pouch of ectoderm that grows out from the upper surface of the embryonic stomodeum and gives rise to the anterior and intermediate lobes of the pituitary gland[MP]. In embryogenesis, Rathke's pouch is a depression in the roof of the developing mouth in front of the buccopharyngeal membrane. It gives rise to the anterior pituitary (adenohypophysis), a part of the endocrine system[WP]." [MP:0003817, Wikipedia:Rathke's_pouch] subset: pheno_slim synonym: "adenohypophysial pouch" NARROW [EHDAA2:0001588] synonym: "craniobuccal pouch" RELATED [] synonym: "craniopharyngeal pouch" RELATED [] synonym: "hypophyseal diverticulum" RELATED [https://orcid.org/0000-0002-6601-2165] synonym: "hypophyseal pouch" RELATED [ISBN:0073040584] synonym: "nasohypophyseal pouch" RELATED SENSU [http://webs.lander.edu/rsfox/invertebrates/ammocoetes.html] synonym: "pituitary diverticulum" RELATED [MP:0003817] synonym: "pouch of Rathke" EXACT [] synonym: "Rathke pouch" EXACT [] synonym: "Rathke's cleft" RELATED [] synonym: "Rathke's cyst" RELATED [] synonym: "Rathke's pocket" RELATED [MP:0003817] synonym: "Rathkes pouch epithelium" NARROW [EHDAA2:0001473] xref: AAO:0011094 xref: EHDAA2:0001588 xref: EMAPA:16725 xref: FMA:302929 xref: NCIT:C34281 xref: NCIT:C54098 xref: neuronames:1516 xref: SCTID:362583008 xref: SCTID:61127000 xref: UMLS:C0229548 {source="ncithesaurus:Rathke_s_Pouch"} xref: UMLS:C1709841 {source="ncithesaurus:Rathke_Pouch_Epithelium"} xref: VHOG:0000674 xref: Wikipedia:Rathke's_pouch xref: XAO:0000430 is_a: UBERON:0005423 ! developing anatomical structure is_a: UBERON:0007499 {source="EHDAA2"} ! epithelial sac is_a: UBERON:0010371 ! ecto-epithelium relationship: BFO:0000050 UBERON:0000033 ! part of head relationship: RO:0002202 UBERON:0000930 {source="MP"} ! develops from stomodeum relationship: RO:0002202 UBERON:0009122 {source="NCBIBook:NBK53175"} ! develops from adenohypophyseal placode property_value: skos:prefLabel "Rathke's pouch" xsd:string [Term] id: UBERON:0005357 name: brain ependyma def: "The ependymal cell layer that lines the brain ventricles." [http://orcid.org/0000-0002-6601-2165, ISBN:0387949542] subset: pheno_slim synonym: "ependyma of ventricular system of brain" EXACT [FMA:242837] xref: EMAPA:35183 xref: FMA:242837 xref: MA:0000809 xref: MESH:D004805 is_a: UBERON:0004670 ! ependyma intersection_of: UBERON:0004670 ! ependyma intersection_of: BFO:0000050 UBERON:0004086 ! part of brain ventricle relationship: BFO:0000050 UBERON:0004086 ! part of brain ventricle relationship: RO:0002433 UBERON:0003947 ! contributes to morphology of brain ventricle/choroid plexus property_value: skos:prefLabel "brain ependyma" xsd:string [Term] id: UBERON:0005358 name: ventricle of nervous system def: "A layer in the central nervous system that lines system of communicating cavities in the brain and spinal cord." [https://github.com/obophenotype/uberon/issues/300] synonym: "region of wall of ventricular system of neuraxis" RELATED [FMA:242770] synonym: "ventricular layer" EXACT [EMAPA:35209] xref: EMAPA:35209 xref: FMA:242770 is_a: UBERON:0004923 ! organ component layer relationship: BFO:0000050 UBERON:0001016 ! part of nervous system property_value: skos:prefLabel "ventricle of nervous system" xsd:string property_value: terms:contributor https://orcid.org/0000-0002-6601-2165 [Term] id: UBERON:0005359 name: spinal cord ependyma def: "The ependymal cell layer that lines the spinal cord." [http://orcid.org/0000-0002-6601-2165, ISBN:0387949542] subset: pheno_slim synonym: "ependyma of central canal of spinal cord" EXACT [FMA:242839] synonym: "spinal cord ependymal layer" EXACT [MA:0001125] synonym: "spinal cord ventricular layer" RELATED [] xref: EMAPA:35791 xref: FMA:242839 xref: MA:0001125 xref: SCTID:369278000 is_a: UBERON:0004670 ! ependyma intersection_of: UBERON:0004670 ! ependyma intersection_of: BFO:0000050 UBERON:0002240 ! part of spinal cord relationship: BFO:0000050 UBERON:0002291 ! part of central canal of spinal cord relationship: RO:0002202 UBERON:0034710 ! develops from spinal cord ventricular layer relationship: RO:0002433 UBERON:0002240 ! contributes to morphology of spinal cord property_value: skos:prefLabel "spinal cord ependyma" xsd:string [Term] id: UBERON:0005362 name: vagus X ganglion def: "The group of sensory neuron cell bodies associated with the vagus nerve." [ISBN:0-683-40008-8, MP:0001100] subset: human_reference_atlas subset: pheno_slim synonym: "ganglion of vagus nerve" EXACT [FMA:53472] synonym: "gX" BROAD [ZFA:0007067] synonym: "right glossopharyngeal ganglion" EXACT [FMA:53472] synonym: "vagal ganglion" EXACT [ZFA:0007067] synonym: "vagus ganglion" EXACT [] synonym: "vagus neural ganglion" EXACT [FMA:53472] synonym: "vagus X" RELATED [EMAPA:16798] xref: EMAPA:16798 xref: FMA:53472 xref: MA:0001081 xref: SCTID:244452001 xref: TAO:0007067 xref: VHOG:0000684 xref: Wikipedia:Vagus_ganglion xref: ZFA:0007067 is_a: UBERON:0009127 {source="ZFA"} ! epibranchial ganglion intersection_of: UBERON:0000045 ! ganglion intersection_of: extends_fibers_into UBERON:0001759 ! vagus nerve relationship: extends_fibers_into UBERON:0001759 ! vagus nerve property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "vagus X ganglion" xsd:string [Term] id: UBERON:0005363 name: inferior vagus X ganglion def: "The large group of sensory neuron cell bodies, anterior to the jugular vein, associated with the vagus nerve (tenth cranial nerve)." [ISBN:0-683-40008-8, MP:0001087, PMID:9362461] subset: efo_slim subset: human_reference_atlas subset: pheno_slim synonym: "ganglion inferius (nervus vagus)" EXACT [FMA:6230] synonym: "ganglion inferius nervi vagi" EXACT OMO:0003011 [Wikipedia:Inferior_ganglion_of_vagus_nerve] synonym: "ganglion inferius nervus vagi" EXACT OMO:0003011 [FMA:6230, FMA:TA] synonym: "ganglion nodosum" EXACT OMO:0003011 [Wikipedia:Inferior_ganglion_of_vagus_nerve] synonym: "inferior ganglion of vagus" EXACT [FMA:6230] synonym: "inferior ganglion of vagus nerve" EXACT [FMA:6230] synonym: "inferior vagus ganglion" RELATED [EMAPA:17155] synonym: "inferior vagus X" BROAD [EMAPA:17155] synonym: "nodose ganglia" RELATED OMO:0003004 [] synonym: "nodose ganglion" EXACT [FMA:6230] synonym: "tenth cranial nerve nodose ganglion" EXACT [FMA:6230] synonym: "vagus nerve inferior ganglion" EXACT [FMA:6230] synonym: "vagus nerve nodose ganglion" EXACT [FMA:6230] synonym: "vagus X inferior ganglion" RELATED [VHOG:0000685] xref: EFO:0002516 xref: EHDAA2:0004622 xref: EMAPA:17155 xref: FMA:6230 xref: MA:0001082 xref: MESH:D009620 xref: SCTID:14420006 xref: VHOG:0000685 xref: Wikipedia:Inferior_ganglion_of_vagus_nerve is_a: UBERON:0005362 ! vagus X ganglion is_a: UBERON:0010313 ! neural crest-derived structure relationship: RO:0002202 UBERON:0009126 {source="EHDAA2"} ! develops from nodosal placode relationship: RO:0002202 UBERON:0010258 {source="EHDAA2"} ! develops from mesenchyme from rhombencephalic neural crest property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0005364 name: superior vagus X ganglion def: "The upper ganglion of the vagus nerve located at the jugular foramen." [ISBN:0-683-40008-8, MP:0001101] subset: human_reference_atlas subset: pheno_slim synonym: "ganglion superius (nervus vagus)" EXACT [FMA:6229] synonym: "ganglion superius nervus vagi" EXACT OMO:0003011 [FMA:6229, FMA:TA] synonym: "gasserian ganglion" RELATED [EMAPA:17156] synonym: "jugular ganglion" RELATED [FMA:6229] synonym: "superior ganglion of vagus" EXACT [FMA:6229] synonym: "superior ganglion of vagus nerve" EXACT [FMA:6229] synonym: "superior vagus ganglion" EXACT [] synonym: "superior vagus X" BROAD [EMAPA:17156] synonym: "tenth cranial nerve jugular ganglion" EXACT [FMA:6229] synonym: "vagus nerve jugular ganglion" EXACT [FMA:6229] synonym: "vagus nerve superior ganglion" EXACT [FMA:6229] synonym: "vagus X superior ganglion" RELATED [VHOG:0000686] xref: EMAPA:17156 xref: FMA:6229 xref: MA:0001083 xref: SCTID:280197008 xref: VHOG:0000686 xref: Wikipedia:Superior_ganglion_of_vagus_nerve is_a: UBERON:0005362 ! vagus X ganglion property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0005366 name: olfactory lobe def: "The lobe at the anterior part of each cerebral hemisphere, responsible for olfactory functions." [UBERON:cjm] subset: efo_slim subset: pheno_slim xref: BTO:0001362 xref: EFO:0000108 xref: EHDAA2_RETIRED:0001294 xref: EHDAA:5480 xref: EMAPA:17778 xref: MA:0002413 xref: MIAA:0000116 xref: NCIT:C33204 xref: neuronames:2078 xref: UMLS:C0178780 {source="ncithesaurus:Olfactory_Lobe"} xref: VHOG:0000833 is_a: UBERON:0016526 ! lobe of cerebral hemisphere property_value: skos:prefLabel "olfactory lobe" xsd:string [Term] id: UBERON:0005367 name: hippocampus granule cell layer subset: pheno_slim synonym: "hippocampus granular layer" RELATED [] xref: EMAPA:35406 xref: MA:0000954 is_a: BFO:0000002 is_a: UBERON:0002305 ! layer of hippocampus intersection_of: UBERON:0002305 ! layer of hippocampus intersection_of: RO:0002473 CL:0001033 ! composed primarily of hippocampal granule cell relationship: RO:0002473 CL:0001033 ! composed primarily of hippocampal granule cell property_value: IAO:0000116 "TODO - check this. The granule layer is typically in the dentate gyrus, under some definitions of hippocampus, the DG is included, thus making this layer a hippocampal layer" xsd:string [Term] id: UBERON:0005371 name: hippocampus stratum oriens def: "Layer that is part of the CA fields of the hippocampus consisting of a narrow relatively cell free layer located deep to the pyramidal cell layer extending through areas CA1, CA2 and CA3. (adapted from Paxinos The rat central nervous system, 2nd ed, Academic Press, San Diego, 1995)." [BIRNLEX:4113] subset: pheno_slim synonym: "gyrus cuneus" RELATED OMO:0003011 [NeuroNames:157] synonym: "oriens layer of hippocampus" EXACT [BIRNLEX:4113] synonym: "oriens layer of the hippocampus" EXACT [BIRNLEX:4113] synonym: "polymorphic layer of hippocampus" EXACT [BIRNLEX:4113] synonym: "polymorphic layer of the hippocampus" EXACT [BIRNLEX:4113] synonym: "stratum oriens" EXACT [BIRNLEX:4113] synonym: "stratum oriens hippocampi" EXACT OMO:0003011 [FMA:83893, FMA:TA] xref: BAMS:Or xref: BIRNLEX:4113 xref: EMAPA:35412 xref: FMA:83893 xref: MA:0000958 xref: neuronames:157 {source="BIRNLEX:4113"} is_a: UBERON:0002305 ! layer of hippocampus intersection_of: UBERON:0002305 ! layer of hippocampus intersection_of: BSPO:0001107 UBERON:0002313 ! hippocampus pyramidal layer intersection_of: BSPO:0015014 UBERON:0007639 ! hippocampus alveus relationship: BSPO:0001107 UBERON:0002313 ! hippocampus pyramidal layer relationship: BSPO:0015014 UBERON:0007639 ! hippocampus alveus property_value: skos:prefLabel "hippocampus stratum oriens" xsd:string [Term] id: UBERON:0005372 name: hippocampus stratum radiatum def: "The layer located immediately above the pyramidal cell layer in CA2 and CA1 and superficial to the stratum lucidum in CA3. Suprapyramidal region in which CA3 to CA3 associational connections and CA3 to CA1 Schaffer collateral connections are located." [BIRNLEX:1298] subset: pheno_slim synonym: "radiate layer of hippocampus" EXACT [FMA:83894] synonym: "stratum radiatum" EXACT [BIRNLEX:1298] synonym: "stratum radiatum hippocampi" EXACT OMO:0003011 [FMA:83894, FMA:TA] synonym: "stratum radiatum of the hippocampus" RELATED [BAMS:Rad] xref: BAMS:Rad xref: BIRNLEX:1298 xref: EMAPA:35413 xref: FMA:83894 xref: MA:0000959 xref: neuronames:158 {source="BIRNLEX:1298"} is_a: UBERON:0002305 ! layer of hippocampus intersection_of: UBERON:0002305 ! layer of hippocampus intersection_of: BSPO:0001107 UBERON:0002313 ! hippocampus pyramidal layer intersection_of: BSPO:0015014 UBERON:0007637 ! hippocampus stratum lucidum relationship: BSPO:0001107 UBERON:0002313 ! hippocampus pyramidal layer relationship: BSPO:0015014 UBERON:0007637 ! hippocampus stratum lucidum property_value: skos:prefLabel "hippocampus stratum radiatum" xsd:string [Term] id: UBERON:0005375 name: spinal cord ventral column def: "The area of white matter of the spinal cord located on either side of the ventral (anterior) medial fissure." [ISBN:0-683-40008-8, MP:0009679] subset: pheno_slim synonym: "anterior column" EXACT [] synonym: "spinal cord anterior column" EXACT [] synonym: "ventral column" EXACT [] xref: EV:0100326 xref: MA:0002751 xref: neuronames:269 xref: VHOG:0001622 is_a: UBERON:0016550 ! spinal cord column relationship: BFO:0000050 UBERON:0002180 ! part of ventral funiculus of spinal cord relationship: RO:0002433 UBERON:0002318 ! contributes to morphology of white matter of spinal cord [Term] id: UBERON:0005376 name: olfactory bulb external plexiform layer def: "Cytoarchitectural part of the olfactory bulb, lying superior to the mitral cell layer and inferior to the glomerular layer. The EPL is mostly neuropil composed almost entirely of mitral and tulfted cell dendrites and granule cell dendrites and their synaptic inputs." [NLXANAT:20090403] subset: pheno_slim synonym: "EPL" RELATED OMO:0003000 [BTO:0001319] synonym: "external plexiform layer" BROAD [BTO:0001319] synonym: "external plexiform layer of the olfactory bulb" RELATED [BAMS:EPl] synonym: "OB outer plexiform layer" RELATED [DMBA:OB-Opl] synonym: "olfactory bulb main external plexiform layer" EXACT [NLXANAT:20090403] xref: BAMS:EPl xref: BTO:0001319 xref: DMBA:15913 xref: EMAPA:35607 xref: MA:0000969 xref: NLXANAT:20090403 is_a: UBERON:0009950 ! olfactory bulb plexiform layer property_value: skos:prefLabel "olfactory bulb external plexiform layer" xsd:string [Term] id: UBERON:0005377 name: olfactory bulb glomerular layer def: "The glomerular layer is the most superficial layer, consisting of mitral cell dendritic arborizations (glomeruli), olfactory nerve fibers, and periglomerular cells. Periglomerular cells contact multiple mitral cell dendrites within the glomeruli and provide lateral inhibition of neighboring glomeruli while allowing excitation of a specific mitral cell dendritic tree. Each mitral cell is contacted by at least 1000 olfactory nerve fibers[BTO]. Portion of tissue which is located in between the primary olfactory fiber layer and the external cellular layer of the olfactory bulb[ZFA]." [BTO:0001317, https://github.com/obophenotype/uberon/issues/260] subset: pheno_slim subset: vertebrate_core synonym: "glomerular layer" BROAD [BTO:0001317, ZFA:0000357] synonym: "glomerular layer of the olfactory bulb" RELATED [BAMS:Gl] synonym: "olfactory bulb main glomerulus" EXACT [NLXANAT:1005007] synonym: "stratum glomerulosum bulbi olfactorii" EXACT [ZFA:0000357] xref: BAMS:Gl xref: BTO:0001317 xref: DHBA:11327 xref: EMAPA:35608 xref: MA:0000970 xref: MBA:212 xref: neuronames:2710 xref: NLXANAT:1005007 xref: TAO:0000357 xref: ZFA:0000357 is_a: UBERON:0004001 ! olfactory bulb layer property_value: skos:prefLabel "olfactory bulb glomerular layer" xsd:string [Term] id: UBERON:0005378 name: olfactory bulb granule cell layer def: "The granule cell layer contains multiple small round neurons that lack axons. Long dendritic processes of the neurons reach the more superficial layers and inhibit mitral cells and tufted cells. Small distal processes make contacts with the exiting mitral cell axons." [BTO:0001327] subset: pheno_slim synonym: "accessory olfactory bulb granule cell layer" RELATED [BAMS:gr] synonym: "granule cell layer" BROAD [BTO:0001327] synonym: "granule layer of main olfactory bulb" RELATED [NLXANAT:20090404] synonym: "main olfactory bulb granule cell layer" RELATED [BAMS:gr, BAMS:MOBgr] synonym: "main olfactory bulb, granule layer" RELATED [BAMS:MOBgr] synonym: "olfactory bulb main granule cell layer" EXACT [NLXANAT:20090404] xref: BAMS:MOBgr xref: BTO:0001327 xref: DMBA:15909 xref: EMAPA:35609 xref: MA:0000971 xref: MBA:220 xref: neuronames:2714 xref: NLXANAT:20090404 is_a: UBERON:0004001 ! olfactory bulb layer property_value: skos:prefLabel "olfactory bulb granule cell layer" xsd:string [Term] id: UBERON:0005381 name: dentate gyrus granule cell layer def: "Granule cell layer is also called the DG principal cell layer. This one of the three layers of dentate gyrus that lies deep to the molecular layer and is made of densely packed layer that is four to eight granule cells thick." [BIRNLEX:4129] subset: pheno_slim synonym: "dentate gyrus, granule cell layer" RELATED [BAMS:DG-sg] synonym: "DG granule cell layer" EXACT [BIRNLEX:4129] synonym: "granular layer of dentate gyrus" EXACT [FMA:83146] synonym: "granular layer of the dentate gyrus" RELATED [BAMS:GrDG] synonym: "stratum granulare gyri dentati" EXACT OMO:0003011 [FMA:83146, FMA:TA] xref: BAMS:DG-sg xref: BAMS:GrDG xref: BAMS:sg xref: BIRNLEX:4129 xref: DMBA:16122 xref: EMAPA:35276 xref: FMA:83146 xref: MA:0000946 xref: MBA:632 xref: neuronames:2122 is_a: BFO:0000002 is_a: UBERON:0002304 ! layer of dentate gyrus intersection_of: UBERON:0002304 ! layer of dentate gyrus intersection_of: BSPO:0001107 UBERON:0004679 ! dentate gyrus molecular layer relationship: BSPO:0001107 UBERON:0004679 ! dentate gyrus molecular layer relationship: RO:0002131 CL:0000118 ! overlaps basket cell relationship: RO:0002473 CL:2000089 ! composed primarily of dentate gyrus granule cell property_value: skos:prefLabel "dentate gyrus granule cell layer" xsd:string [Term] id: UBERON:0005382 name: dorsal striatum def: "Dorsal components of the striatum comprising the caudate nucleus and the putamen, in species that have distinct nuclei; the caudoputamen in species which don't." [NLXANAT:1010001] subset: human_reference_atlas synonym: "caudoputamen" RELATED [NLXANAT:100312] synonym: "corpus striatum" RELATED [Wikipedia:Dorsal_striatum] synonym: "dorsal basal ganglia" RELATED [BTO:0004701] synonym: "dorsal basal ganglion" RELATED [BTO:0004701] synonym: "striated body" RELATED [Wikipedia:Dorsal_striatum] synonym: "striatum dorsal region" EXACT [ABA:STRd] synonym: "striatum dorsale" RELATED [BTO:0004701] xref: BAMS:Dorsal_striatum xref: BAMS:STRd xref: BAMS:StrD xref: BTO:0004701 xref: EMAPA:36575 xref: FMA:77620 xref: MA:0002971 xref: MBA:485 xref: neuronames:2340 xref: NLXANAT:1010001 xref: PBA:10081 xref: Wikipedia:Dorsal_striatum is_a: UBERON:0011300 ! gray matter of telencephalon relationship: BFO:0000050 UBERON:0002435 {source="NIFSTD"} ! part of striatum relationship: BFO:0000051 UBERON:0001873 ! has part caudate nucleus relationship: BFO:0000051 UBERON:0001874 ! has part putamen property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "dorsal striatum" xsd:string [Term] id: UBERON:0005383 name: caudate-putamen def: "Regional part of telencephalon in some species, e.g., rodent, equivalent to the dorsal striatum (caudate nucleus and putamen). Unlike the dorsal striatum of primates, for example, the caudoputamen is not split into separate nuclei by the fibers of the internal capsule. Rather, the internal capsule splits into fiber bundles which course through the structure." [NLXANAT:100312] subset: efo_slim subset: pheno_slim synonym: "caudate putamen" EXACT [] synonym: "caudate putamen" RELATED [NLXANAT:100312] synonym: "caudate putamen (striatum)" RELATED [BAMS:CPu] synonym: "caudate-putamen" RELATED [NLXANAT:100312] synonym: "caudateputamen" EXACT [NLXANAT:100312] synonym: "caudateputamen" RELATED [NLXANAT:100312] synonym: "caudoputamen" EXACT [NLXANAT:100312] synonym: "dorsal striatum" RELATED [NLXANAT:100312] synonym: "neostriatum" RELATED [NLXANAT:100312] synonym: "striatum" RELATED [NLXANAT:100312] xref: BAMS:CP xref: BAMS:CPu xref: BM:Tel-C-Pu xref: BTO:0000212 xref: EFO:0001912 xref: EMAPA:19095 xref: MA:0000893 xref: MBA:672 xref: NLXANAT:100312 is_a: UBERON:0011215 ! central nervous system cell part cluster relationship: BFO:0000050 UBERON:0005382 {source="MA"} ! part of dorsal striatum relationship: BFO:0000051 UBERON:0001873 ! has part caudate nucleus relationship: BFO:0000051 UBERON:0001874 ! has part putamen relationship: RO:0002433 UBERON:0002435 ! contributes to morphology of striatum relationship: RO:0002473 UBERON:0002020 ! composed primarily of gray matter property_value: IAO:0000116 "check - rodents. The caudate nucleus and putamen are separated by a clear white matter bundle in most species but not in rodents (MM)" xsd:string property_value: IAO:0000116 "we do not currently place rodent-specific taxon constraints here as this would cause taxon violations. There is an argument for merging this into dorsal striatum and treating the distinction as phenotypic" xsd:string property_value: skos:prefLabel "caudate-putamen" xsd:string [Term] id: UBERON:0005384 name: nasal cavity epithelium def: "An epithelium that lines the nasal cavity." [http://orcid.org/0000-0002-6601-2165] subset: pheno_slim synonym: "nasal epithelium" EXACT [FMA:63140] synonym: "nasal mucosa" RELATED [MA:0001324] xref: CALOHA:TS-0656 xref: EHDAA2:0001227 xref: EHDAA:6803 xref: EMAPA:17605 xref: FMA:63140 xref: MA:0001324 xref: NCIT:C49261 xref: UMLS:C1709151 {source="ncithesaurus:Nasal_Cavity_Epithelium"} xref: VHOG:0000501 is_a: UBERON:0003350 ! epithelium of mucosa is_a: UBERON:0004814 ! upper respiratory tract epithelium is_a: UBERON:0019306 ! nose epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: BFO:0000050 UBERON:0001826 ! part of nasal cavity mucosa relationship: BFO:0000050 UBERON:0001826 ! part of nasal cavity mucosa relationship: RO:0002007 UBERON:0015788 ! bounding layer of olfactory apparatus chamber relationship: RO:0002433 UBERON:0000004 ! contributes to morphology of nose relationship: RO:0002433 UBERON:0004785 ! contributes to morphology of respiratory system mucosa property_value: IAO:0000116 "this class may in future be split into the embryonic precursor of the oronasal membrane and the structure that is part of the mucosa in the developed organism" xsd:string property_value: skos:prefLabel "nasal cavity epithelium" xsd:string [Term] id: UBERON:0005385 name: nasal cavity respiratory epithelium def: "An epithelium that is part of the respiratory segment of the nasal mucosa [Automatically generated definition]." [https://github.com/obophenotype/uberon/issues/50, OBOL:automatic] xref: EHDAA2:0001230 xref: EHDAA:6807 xref: EMAPA:17607 xref: MA:0001326 xref: NCIT:C49262 xref: UMLS:C1709152 {source="ncithesaurus:Nasal_Cavity_Respiratory_Epithelium"} is_a: UBERON:0005384 ! nasal cavity epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: BFO:0000050 UBERON:0015786 ! part of respiratory segment of nasal mucosa relationship: BFO:0000050 UBERON:0015786 ! part of respiratory segment of nasal mucosa property_value: terms:contributor https://orcid.org/0000-0002-6601-2165 [Term] id: UBERON:0005386 name: olfactory segment of nasal mucosa def: "That portion of the nasal mucosa containing the sensory endings for olfaction; the organ of smell[MESH]." [MESH:A04.531.520.573, Wikipedia:Olfactory_mucosa] subset: pheno_slim synonym: "olfactory area of nasal mucosa" EXACT [FMA:77199] synonym: "olfactory mucosa" EXACT [] synonym: "olfactory part of nasal mucosa" EXACT [FMA:77199] synonym: "olfactory zone of nasal mucosa" EXACT [FMA:77199] synonym: "pars olfactoria tunicae mucosae nasi" EXACT OMO:0003011 [FMA:77199, FMA:TA] synonym: "pars olfactoria tunicae mucosae nasi" RELATED OMO:0003011 [Wikipedia:Olfactory_mucosa] xref: CALOHA:TS-2197 xref: EMAPA:37918 {source="MA:th"} xref: FMA:77199 xref: GAID:303 xref: MESH:D009831 xref: NCIT:C33205 xref: UMLS:C0028937 {source="ncithesaurus:Olfactory_Mucosa"} xref: Wikipedia:Olfactory_mucosa is_a: BFO:0000002 is_a: UBERON:0001826 ! nasal cavity mucosa intersection_of: UBERON:0001826 ! nasal cavity mucosa intersection_of: BFO:0000050 UBERON:0005725 ! part of olfactory system intersection_of: BFO:0000051 UBERON:0001997 ! has part olfactory epithelium disjoint_from: UBERON:0015786 ! respiratory segment of nasal mucosa relationship: BFO:0000050 UBERON:0005725 ! part of olfactory system relationship: BFO:0000051 UBERON:0001997 ! has part olfactory epithelium property_value: skos:prefLabel "olfactory segment of nasal mucosa" xsd:string [Term] id: UBERON:0005388 name: photoreceptor array def: "An array of photoreceptors and any supporting cells found in an eye." [https://orcid.org/0000-0002-6601-2165] synonym: "light-sensitive tissue" EXACT [] xref: FBbt:00004200 {sssom:mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"} is_a: UBERON:0004923 ! organ component layer intersection_of: UBERON:0004923 ! organ component layer intersection_of: BFO:0000050 UBERON:0000970 ! part of eye intersection_of: RO:0002473 CL:0000210 ! composed primarily of photoreceptor cell relationship: BFO:0000050 UBERON:0000970 ! part of eye relationship: BFO:0000050 UBERON:0001016 ! part of nervous system relationship: RO:0002473 CL:0000210 ! composed primarily of photoreceptor cell property_value: skos:prefLabel "photoreceptor array" xsd:string [Term] id: UBERON:0005389 name: transparent eye structure def: "A transparent structure that is part of a visual sense organ, the function of which is to direct or focus light onto a photoreceptor array." [http://orcid.org/0000-0002-6601-2165] subset: grouping_class synonym: "lens" NARROW [] is_a: UBERON:0000061 ! anatomical structure relationship: BFO:0000050 UBERON:0000970 ! part of eye relationship: RO:0000086 PATO:0000964 ! has quality transparent property_value: skos:prefLabel "transparent eye structure" xsd:string [Term] id: UBERON:0005390 name: cortical layer I def: "The most superficial layer of the neocortex characterized by a paucity of cell bodies." [NLXANAT:090807] synonym: "cerebral cortex, layer 1" EXACT [ABA:CTX1] synonym: "lamina molecularis isocorticis [lamina I]" EXACT OMO:0003011 [FMA:83900, FMA:TA] synonym: "layer 1 of neocortex" EXACT [NLXANAT:090807] synonym: "layer I of neocortex" EXACT [NLXANAT:090807] synonym: "molecular layer" RELATED [] synonym: "molecular layer of cerebral cortex" EXACT [ncithesaurus:Molecular_layer] synonym: "molecular layer of isocortex [layer i]" EXACT [FMA:83900] synonym: "molecular layer of neocortex" EXACT [FMA:83900, NLXANAT:090807] synonym: "neocortex layer 1" EXACT [NLXANAT:090807] synonym: "neocortex layer I" EXACT [NLXANAT:090807] synonym: "neocortex molecular layer" EXACT [NLXANAT:090807] synonym: "neocortex plexiform layer" EXACT [NLXANAT:090807] synonym: "plexiform layer" RELATED [] synonym: "plexiform layer of neocortex" EXACT [NLXANAT:090807] xref: ABA:CTX1 xref: BTO:0004906 xref: EMAPA:35255 xref: FMA:83900 xref: MA:0000897 xref: NCIT:C33137 xref: neuronames:2444 xref: NLXANAT:090807 xref: PBA:294021786 xref: UMLS:C1709063 {source="ncithesaurus:Molecular_Layer"} is_a: BFO:0000002 is_a: UBERON:0002301 ! layer of neocortex relationship: RO:0002202 UBERON:0014935 {source="NBK10047"} ! develops from cerebral cortex marginal layer property_value: skos:prefLabel "cortical layer I" xsd:string [Term] id: UBERON:0005391 name: cortical layer II def: "Layer of neocortex lying just deep to molecular layer characterized by numerous small cell bodies." [NLXANAT:090808] synonym: "cerebral cortex, layer 2" EXACT [ABA:CTX2] synonym: "EGL" RELATED OMO:0003000 [] synonym: "external granular cell layer" RELATED [] synonym: "external granular layer" RELATED [] synonym: "external granular layer of cerebral cortex" RELATED [] synonym: "external granular layer of isocortex [layer II]" EXACT [FMA:77804] synonym: "external granular layer of neocortex" EXACT [FMA:77804] synonym: "external granule cell layer" RELATED [] synonym: "external granule cell layer of neocortex" EXACT [NLXANAT:090808] synonym: "granule cell layer of cerebral cortex" RELATED [] synonym: "lamina granularis externa isocorticis [lamina ii]" EXACT OMO:0003011 [FMA:77804, FMA:TA] synonym: "layer II of neocortex" EXACT [NLXANAT:090808] synonym: "neocortex layer 2" EXACT [NLXANAT:090808] synonym: "neocortex layer II" EXACT [NLXANAT:090808] xref: ABA:CTX2 xref: EMAPA:35256 xref: FMA:77804 xref: MA:0000898 xref: NCIT:C32557 xref: neuronames:2446 xref: NLXANAT:090808 xref: PBA:294021800 xref: UMLS:C1517039 {source="ncithesaurus:External_Granular_Layer"} is_a: BFO:0000002 is_a: UBERON:0002301 ! layer of neocortex relationship: BSPO:0001107 UBERON:0005390 ! cortical layer I relationship: RO:0002202 UBERON:0005343 {source="BRAINSPAN"} ! develops from cortical plate property_value: skos:prefLabel "cortical layer II" xsd:string [Term] id: UBERON:0005392 name: cortical layer III def: "Layer of neocortex lying deep to the external granule cell layer defined cytoarchitecturally by numerous small pyramidal neurons." [NLXANAT:090809] synonym: "cerebral cortex, layer 3" EXACT [ABA:CTX3] synonym: "external pyramidal cell layer" EXACT [FMA:77810] synonym: "external pyramidal cell layer of neocortex" EXACT [NLXANAT:090809] synonym: "external pyramidal layer of cerebral cortex" RELATED [ncithesaurus:External_Pyramidal_Cell_Layer] synonym: "external pyramidal layer of isocortex [layer iii]" EXACT [FMA:77810] synonym: "external pyramidal layer of neocortex" EXACT [FMA:77810] synonym: "isocortex, deep supragranular pyramidal layer" RELATED [NeuroNames:2448] synonym: "lamina pyramidalis externa" RELATED OMO:0003011 [NeuroNames:2448] synonym: "lamina pyramidalis externa isocorticis [lamina iii]" EXACT OMO:0003011 [FMA:77810, FMA:TA] synonym: "layer 3 of neocortex" EXACT [NLXANAT:090809] synonym: "layer III of neocortex" EXACT [NLXANAT:090809] synonym: "layer of medium-sized and large pyramidal cells" RELATED [NeuroNames:2448] synonym: "neocortex external pyramidal cell layer" EXACT [NLXANAT:090809] synonym: "neocortex layer 3" EXACT [NLXANAT:090809] synonym: "neocortex layer III" EXACT [NLXANAT:090809] synonym: "pyramidal layer" RELATED [] xref: ABA:CTX3 xref: EMAPA:35257 xref: FMA:77810 xref: MA:0000899 xref: NCIT:C32571 xref: neuronames:2448 xref: NLXANAT:090809 xref: PBA:294021824 xref: UMLS:C1517046 {source="ncithesaurus:External_Pyramidal_Cell_Layer"} is_a: BFO:0000002 is_a: UBERON:0002301 ! layer of neocortex relationship: BFO:0000051 CL:0000598 ! has part pyramidal neuron relationship: BSPO:0001107 UBERON:0005391 ! cortical layer II relationship: RO:0002202 UBERON:0005343 {source="BRAINSPAN"} ! develops from cortical plate property_value: skos:prefLabel "cortical layer III" xsd:string [Term] id: UBERON:0005393 name: cortical layer IV def: "Layer of neocortex lying deep to the external pyramidal cell layer defined cytoarchitecturally by the presence of numerous small cells." [NLXANAT:090810] synonym: "cerebral cortex, layer 4" EXACT [ABA:CTX4] synonym: "internal granular layer" RELATED [] synonym: "internal granular layer of isocortex [layer iv]" EXACT [FMA:77811] synonym: "internal granular layer of neocortex" EXACT [FMA:77811] synonym: "internal granule cell layer of neocortex" EXACT [NLXANAT:090810] synonym: "lamina granularis interna isocorticis [lamina iv]" EXACT OMO:0003011 [FMA:77811, FMA:TA] synonym: "layer 4 of neocortex" EXACT [NLXANAT:090810] synonym: "layer IV of neocortex" EXACT [NLXANAT:090810] synonym: "neocortex internal granule cell layer" EXACT [NLXANAT:090810] synonym: "neocortex layer 4" EXACT [NLXANAT:090810] synonym: "neocortex layer IV" EXACT [NLXANAT:090810] synonym: "neocortical internal granule cell layer" EXACT [NLXANAT:090810] synonym: "neocortical layer IV" EXACT [NLXANAT:090810] xref: ABA:CTX4 xref: EMAPA:35258 xref: FMA:77811 xref: MA:0000900 xref: NCIT:C32844 xref: neuronames:2449 xref: NLXANAT:090810 xref: PBA:294021852 xref: UMLS:C1512872 {source="ncithesaurus:Internal_Granular_Layer"} is_a: BFO:0000002 is_a: UBERON:0002301 ! layer of neocortex relationship: BSPO:0001107 UBERON:0005392 ! cortical layer III relationship: RO:0002202 UBERON:0005343 {source="BRAINSPAN"} ! develops from cortical plate property_value: skos:prefLabel "cortical layer IV" xsd:string [Term] id: UBERON:0005394 name: cortical layer V def: "Layer of neocortex lying deep to the internal granule cell layer (layer 4) defined cytoarchitecturally by the predominance of large pyramidal cell bodies." [NLXANAT:090811] synonym: "betz' cells" EXACT [FMA:77812] synonym: "cerebral cortex, layer 5" EXACT [ABA:CTX5] synonym: "deep layer of large pyramidal cells" RELATED [NeuroNames:2450] synonym: "ganglionic layer" RELATED [] synonym: "ganglionic layer of cerebral cortex" RELATED [] synonym: "inner layer of large pyramidal cells" RELATED [NeuroNames:2450] synonym: "internal pyramidal cell layer of neocortex" EXACT [NLXANAT:090811] synonym: "internal pyramidal layer" RELATED [NeuroNames:2450] synonym: "internal pyramidal layer of isocortex [layer v]" EXACT [FMA:77812] synonym: "internal pyramidal layer of neocortex" EXACT [FMA:77812] synonym: "isocortex, infragranular pyramidal layer" RELATED [NeuroNames:2450] synonym: "lamina ganglionaris" RELATED OMO:0003011 [NeuroNames:2450] synonym: "lamina pyramidalis interna" RELATED OMO:0003011 [NeuroNames:2450] synonym: "lamina pyramidalis interna isocorticis [lamina v]" EXACT OMO:0003011 [FMA:77812, FMA:TA] synonym: "layer 5 of neocortex" EXACT [NLXANAT:090811] synonym: "layer V of neocortex" EXACT [NLXANAT:090811] synonym: "neocortex internal pyramidal cell layer" EXACT [NLXANAT:090811] synonym: "neocortex layer 5" EXACT [NLXANAT:090811] synonym: "neocortex layer V" EXACT [NLXANAT:090811] synonym: "neocortical layer 5" EXACT [NLXANAT:090811] synonym: "neocortical layer V" EXACT [NLXANAT:090811] xref: ABA:CTX5 xref: EMAPA:35259 xref: FMA:77812 xref: MA:0000901 xref: NCIT:C32653 xref: neuronames:2450 xref: NLXANAT:090811 xref: PBA:294021878 xref: UMLS:C1517447 {source="ncithesaurus:Ganglionic_Layer"} is_a: BFO:0000002 is_a: UBERON:0002301 ! layer of neocortex relationship: BFO:0000051 CL:0000598 ! has part pyramidal neuron relationship: BSPO:0001107 UBERON:0005393 ! cortical layer IV relationship: RO:0002202 UBERON:0005343 {source="BRAINSPAN"} ! develops from cortical plate property_value: skos:prefLabel "cortical layer V" xsd:string [Term] id: UBERON:0005395 name: cortical layer VI def: "Innermost layer of neocortex lying deep to the internal pyramidal cell layer defined cytoarchitecturally by cells of varying size." [NLXANAT:090812] synonym: "cerebral cortex, layer 6" EXACT [ABA:CTX6] synonym: "fusiform layer" RELATED [NeuroNames:2451] synonym: "isocortex, polymorph layer" RELATED [NeuroNames:2451] synonym: "lamina multiformis" RELATED OMO:0003011 [NeuroNames:2451] synonym: "lamina multiformis isocorticis [lamina vi]" EXACT OMO:0003011 [FMA:77805, FMA:TA] synonym: "layer VI of neocortex" EXACT [NLXANAT:090812] synonym: "multiform layer" RELATED [NeuroNames:2451] synonym: "multiform layer of isocortex [layer vi]" EXACT [FMA:77805] synonym: "multiform layer of neocortex" EXACT [FMA:77805, NLXANAT:090812] synonym: "neocortex layer 6" EXACT [NLXANAT:090812] synonym: "neocortex layer VI" EXACT [NLXANAT:090812] synonym: "neocortex multiform layer" EXACT [NLXANAT:090812] synonym: "neocortical layer 6" EXACT [NLXANAT:090812] synonym: "neocortical layer VI" EXACT [NLXANAT:090812] synonym: "pleiomorphic layer of neocortex" EXACT [NLXANAT:090812] synonym: "spindle cell layer" RELATED [NeuroNames:2451] xref: ABA:CTX6 xref: EMAPA:35260 xref: FMA:77805 xref: MA:0000902 xref: neuronames:2451 xref: NLXANAT:090812 xref: PBA:294021896 is_a: UBERON:0002301 ! layer of neocortex relationship: BSPO:0001107 UBERON:0005394 ! cortical layer V property_value: skos:prefLabel "cortical layer VI" xsd:string [Term] id: UBERON:0005396 name: carotid artery segment def: "One of: the common carotid artery, or its branches, the external and internal carotid arteries." [https://sourceforge.net/tracker/?func=detail&aid=3486870&group_id=76834&atid=994764, Wikipedia:Carotid_artery] subset: efo_slim subset: grouping_class subset: pheno_slim subset: vertebrate_core synonym: "carotid" EXACT [AAO:0010217] synonym: "carotid artery" EXACT [MA:0001925] synonym: "common carotid arterial subdivision" RELATED [FMA:70504] synonym: "subdivision of common carotid artery" EXACT [FMA:70504] xref: AAO:0010217 xref: BTO:0000168 xref: CALOHA:TS-0116 xref: EFO:0000818 xref: EHDAA:6385 xref: EMAPA:18609 xref: EV:0100379 xref: FMA:70504 xref: GAID:478 xref: galen:CarotidArtery xref: MA:0001925 xref: MAT:0000501 xref: MESH:D002339 xref: NCIT:C12687 xref: SCTID:362040006 xref: SCTID:69105007 xref: TAO:0000097 xref: UMLS:C0007272 {source="ncithesaurus:Carotid_Artery"} xref: VHOG:0000266 xref: Wikipedia:Carotid_artery xref: ZFA:0000097 is_a: UBERON:0004573 {source="FMA"} ! systemic artery property_value: IAO:0000116 "This is a generic grouping class that is the superclass of the trunks/branches of the common carotid artery. Note that AOs vary widely in how they divide up and generalize arteries" xsd:string property_value: skos:prefLabel "carotid artery segment" xsd:string [Term] id: UBERON:0005397 name: brain arachnoid mater def: "An arachnoid mater that surrounds a brain." [OBOL:automatic] synonym: "arachnoidea mater cranialis" EXACT OMO:0003011 [FMA:83981, FMA:TA] synonym: "arachnoidea mater encephali" EXACT OMO:0003011 [FMA:83981, FMA:TA] synonym: "brain arachnoid matter" EXACT [MA:0000814] synonym: "cranial arachnoid mater" EXACT [FMA:83981] xref: EMAPA:32661 xref: FMA:83981 xref: MA:0000814 xref: NCIT:C49331 xref: UMLS:C1707346 xref: VHOG:0000230 is_a: UBERON:0002362 ! arachnoid mater is_a: UBERON:0003547 ! brain meninx intersection_of: UBERON:0002362 ! arachnoid mater intersection_of: RO:0002221 UBERON:0000955 ! surrounds brain relationship: BFO:0000050 UBERON:0003547 ! part of brain meninx relationship: RO:0002221 UBERON:0000955 ! surrounds brain property_value: skos:prefLabel "brain arachnoid mater" xsd:string [Term] id: UBERON:0005398 name: female reproductive gland def: "A sex gland that is part of a female reproductive system." [OBOL:automatic] subset: organ_slim subset: pheno_slim xref: BTO:0000254 xref: MA:0000383 is_a: UBERON:0003937 ! reproductive gland intersection_of: UBERON:0003937 ! reproductive gland intersection_of: BFO:0000050 UBERON:0000474 ! part of female reproductive system relationship: BFO:0000050 UBERON:0003134 ! part of female reproductive organ property_value: skos:prefLabel "female reproductive gland" xsd:string [Term] id: UBERON:0005399 name: male reproductive gland def: "A sex gland that is part of a male reproductive system." [OBOL:automatic] subset: organ_slim subset: pheno_slim synonym: "accessory sex gland" RELATED [EMAPA:19285] xref: BTO:0000080 xref: EMAPA:19285 xref: MA:0000399 is_a: UBERON:0003937 ! reproductive gland intersection_of: UBERON:0003937 ! reproductive gland intersection_of: BFO:0000050 UBERON:0000079 ! part of male reproductive system relationship: BFO:0000050 UBERON:0000079 ! part of male reproductive system [Term] id: UBERON:0005400 name: telencephalon arachnoid mater def: "An arachnoid mater that is part of a telencephalon." [OBOL:automatic] synonym: "telencephalon arachnoid matter" EXACT [MA:0000980] xref: EMAPA:17775 xref: MA:0000980 is_a: UBERON:0003289 ! meninx of telencephalon is_a: UBERON:0003556 ! forebrain arachnoid mater intersection_of: UBERON:0002362 ! arachnoid mater intersection_of: BFO:0000050 UBERON:0001893 ! part of telencephalon property_value: skos:prefLabel "telencephalon arachnoid mater" xsd:string [Term] id: UBERON:0005401 name: cerebral hemisphere gray matter def: "A gray matter that is part of a cerebral hemisphere." [OBOL:automatic] synonym: "cerebral gray matter" EXACT [BTO:0000823] synonym: "cerebral grey matter" EXACT [MA:0000944] synonym: "cerebral hemisphere grey matter" EXACT [] xref: BTO:0000823 xref: CALOHA:TS-2361 xref: EMAPA:37477 {source="MA:th"} xref: FMA:61821 xref: MA:0000944 is_a: UBERON:0011300 ! gray matter of telencephalon intersection_of: UBERON:0002020 ! gray matter intersection_of: BFO:0000050 UBERON:0001869 ! part of cerebral hemisphere relationship: BFO:0000050 UBERON:0001869 ! part of cerebral hemisphere property_value: skos:prefLabel "cerebral hemisphere gray matter" xsd:string [Term] id: UBERON:0005403 name: ventral striatum def: "A composite structure of the telencephalon that is defined in the striatopallidal system by connectivity and neurochemical staining. It includes the nucleus accumbens, the most ventral portions of the caudate nucleus and the putamen, the rostrolateral portion of the anterior perforated substance, the islands of Calleja and a rostral subcommissural portion of substantia innominata. The boundary between the ventral striatum and dorsal striatum is indistinct in sections stained for Nissl substance (Heimer-1995; adapted from Brain Info)." [NLX:57107] subset: efo_slim subset: human_reference_atlas subset: pheno_slim synonym: "striatum ventral region" EXACT [ABA:STRv] synonym: "striatum ventrale" RELATED [BTO:0004702] xref: BAMS:STRv xref: BAMS:StrV xref: BAMS:Ventral_striatum xref: BTO:0004702 xref: DMBA:15858 xref: EFO:0001936 xref: EMAPA:36576 xref: FMA:77614 xref: MA:0002972 xref: MBA:493 xref: neuronames:2341 xref: NLX:57107 xref: PBA:10091 xref: Wikipedia:Ventral_striatum is_a: UBERON:0011300 ! gray matter of telencephalon relationship: BFO:0000050 UBERON:0002435 {source="MA"} ! part of striatum relationship: RO:0002433 UBERON:0002435 ! contributes to morphology of striatum property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "ventral striatum" xsd:string [Term] id: UBERON:0005406 name: perirenal fat def: "The adipose capsule of kidney (or perinephric fat or perirenal fat) is a structure between the renal fascia and renal capsule, and may be regarded as a part of the latter. A different structure, the pararenal fat, is the adipose tissue superficial to the renal fascia." [Wikipedia:Adipose_capsule_of_kidney] synonym: "adipose capsule of kidney" RELATED [MA:0002975] synonym: "capsula adiposa renis" RELATED OMO:0003011 [Wikipedia:Adipose_capsule_of_kidney] synonym: "fatty capsule of kidney" RELATED [MA:0002975] synonym: "perinephric fat" RELATED [MA:0002975] synonym: "periphrenic fascia" RELATED [MA:0002975] synonym: "perirenal fascia" EXACT [FMA:20502] synonym: "perirenal fascia" RELATED [MA:0002975] synonym: "perirenal fat capsule" RELATED PENDING_REVIEW [MA:0002975] synonym: "perirenal fat pad" RELATED PENDING_REVIEW [] xref: EMAPA:36495 xref: FMA:15876 xref: FMA:20502 xref: MA:0002975 xref: SCTID:246901006 xref: Wikipedia:Adipose_capsule_of_kidney is_a: UBERON:0001013 ! adipose tissue relationship: RO:0002162 NCBITaxon:40674 ! in taxon Mammalia property_value: foaf:depiction "https://upload.wikimedia.org/wikipedia/commons/6/69/Illu_kidney.jpg" xsd:anyURI property_value: IAO:0000116 "TODO - split perinephric / perirenal" xsd:string [Term] id: UBERON:0005407 name: sublingual ganglion def: "The small parasympathetic ganglion found anterior to the submandibular gland that provides postsynaptic fibers to the sublingual gland." [ISBN:0-683-40008-8, MP:0010105] subset: pheno_slim xref: EHDAA2:0001938 xref: EHDAA:10101 xref: FMA:77591 xref: MA:0002982 is_a: UBERON:0001808 ! parasympathetic ganglion intersection_of: UBERON:0000045 ! ganglion intersection_of: extends_fibers_into UBERON:0001832 ! sublingual gland relationship: extends_fibers_into UBERON:0001832 ! sublingual gland [Term] id: UBERON:0005408 name: circumventricular organ def: "Any of any of the secretory or sensory organs located in the brain region around or in relation to the ventricular system that are characterized by extensive vasculature and a lack of a normal blood brain barrier (BBB) and allow for the linkage between the central nervous system and peripheral blood flow." [MP:0013562] subset: pheno_slim synonym: "circumventricular organ" EXACT [NLXANAT:20090312] synonym: "circumventricular organ of neuraxis" EXACT [FMA:84081] synonym: "CVO" EXACT OMO:0003000 [NLXANAT:20090312] xref: EMAPA:35243 xref: FMA:84081 xref: MA:0002942 xref: neuronames:1242 xref: NLXANAT:20090312 xref: Wikipedia:Circumventricular_organs is_a: UBERON:0002616 ! regional part of brain property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/7/7d/Gray734.png" xsd:anyURI property_value: skos:prefLabel "circumventricular organ" xsd:string [Term] id: UBERON:0005409 name: alimentary part of gastrointestinal system def: "The part of the digestive system that excludes the hepatobiliary system." [http://orcid.org/0000-0002-6601-2165] subset: pheno_slim synonym: "alimentary system" RELATED [MA:0000323] synonym: "alimentary tract" RELATED [MA:0000323] synonym: "gastro-intestinal system" RELATED [FMA:71132] synonym: "gastroenterological system" RELATED [UBERON:cjm] synonym: "gastrointestinal (GI) tract" RELATED [GAID:294] synonym: "gastrointestinal system" RELATED [FMA:71132] synonym: "gastrointestinal tract" RELATED INCONSISTENT [FMA:71132] synonym: "GI tract" RELATED [GAID:294] xref: BTO:0000058 xref: CALOHA:TS-0407 xref: EHDAA2:0000110 xref: EHDAA:514 xref: EMAPA:16246 xref: FMA:71132 xref: GAID:294 xref: galen:GastrointestinalTract xref: MA:0000323 xref: MESH:D041981 xref: NCIT:C12378 xref: SCTID:373871007 xref: UMLS:C0012240 {source="ncithesaurus:Gastrointestinal_System"} xref: VHOG:0000412 is_a: UBERON:0000467 ! anatomical system relationship: BFO:0000050 UBERON:0001007 ! part of digestive system relationship: RO:0002492 UBERON:0000066 ! existence ends during fully formed stage property_value: IAO:0000116 "the decision to split digestive and gastrointestinal in this way may be revisited. As it currently stands, this class more closely aligns what MA calls the alimentary system" xsd:string property_value: skos:prefLabel "alimentary part of gastrointestinal system" xsd:string [Term] id: UBERON:0005410 name: cartilaginous otic capsule def: "An otic capsule endochondral element that is composed primarily of cartilage tissue." [OBOL:automatic] subset: vertebrate_core synonym: "auditory capsule" EXACT [ZFA:0001500] synonym: "otic capsule cartilage element" EXACT [] xref: EHDAA2:0001333 xref: EHDAA:4704 xref: EMAPA:18803 xref: EMAPA:37467 {source="MA:th"} xref: TAO:0001500 xref: ZFA:0001500 is_a: UBERON:0003932 ! cartilage element of chondrocranium is_a: UBERON:0004637 ! otic capsule intersection_of: UBERON:0004637 ! otic capsule intersection_of: RO:0002473 UBERON:0002418 ! composed primarily of cartilage tissue relationship: RO:0002202 UBERON:0010349 {source="EHDAA2"} ! develops from otic capsule pre-cartilage condensation property_value: skos:prefLabel "cartilaginous otic capsule" xsd:string [Term] id: UBERON:0005411 name: bony otic capsule def: "The cartilage or bony capsule surrounding the inner ear mechanism." [ISBN:0-683-40008-8, MP:0000039] subset: pheno_slim synonym: "otic capsule bone" EXACT [] xref: EMAPA:37466 {source="MA:th"} xref: MA:0000252 is_a: UBERON:0002513 ! endochondral bone is_a: UBERON:0004637 ! otic capsule is_a: UBERON:0011164 ! neurocranium bone intersection_of: UBERON:0004637 ! otic capsule intersection_of: RO:0002473 UBERON:0002481 ! composed primarily of bone tissue relationship: BFO:0000050 UBERON:0001694 {source="EHDAA2"} ! part of petrous part of temporal bone relationship: RO:0002202 UBERON:0005410 ! develops from cartilaginous otic capsule property_value: skos:prefLabel "bony otic capsule" xsd:string [Term] id: UBERON:0005417 name: forelimb bud def: "A limb bud that develops into a forelimb." [http://orcid.org/0000-0002-6601-2165] comment: Genes: Tbx5 specifies forelimbs. Wnt2b restricts Fgf10 in chick // In tetrapods, the position of the forelimb is associated with the anterior expression border of Hoxc6 in the paraxial mesoderm (Burke et al., 1995) subset: pheno_slim synonym: "anterior limb bud" EXACT [] synonym: "arm bud" RELATED [] synonym: "limb bud - forelimb" EXACT [MIAA:0000065] synonym: "upper limb bud" EXACT [RETIRED_EHDAA2:0003198] synonym: "wing bud" NARROW SENSU [NCBITaxon:8782, OBOL:automatic] xref: AAO:0010381 xref: BTO:0001645 xref: EHDAA:1699 xref: EMAPA:16406 xref: FMA:296782 xref: MIAA:0000065 xref: RETIRED_EHDAA2:0003198 xref: SCTID:346062002 xref: XAO:0003065 is_a: UBERON:0004347 ! limb bud is_a: UBERON:0005419 ! pectoral appendage bud intersection_of: UBERON:0004347 ! limb bud intersection_of: RO:0002387 UBERON:0002102 ! has potential to develop into forelimb disjoint_from: UBERON:0005418 {source="lexical"} ! hindlimb bud relationship: RO:0002387 UBERON:0002102 ! has potential to develop into forelimb [Term] id: UBERON:0005418 name: hindlimb bud def: "A limb bud that develops into a hindlimb." [http://orcid.org/0000-0002-6601-2165] comment: Genes: Tbx4 specifies hindlimbs. Wnt8c restricts Fgf10 in chick. subset: pheno_slim synonym: "hind limb bud" EXACT [XAO:0003066] synonym: "leg bud" RELATED [] synonym: "limb bud - hindlimb" RELATED [] synonym: "posterior limb bud" EXACT [] xref: AAO:0010382 xref: EHDAA:2358 xref: EMAPA:16779 xref: MIAA:0000256 xref: RETIRED_EHDAA2:0003197 xref: SCTID:346164003 xref: XAO:0003066 is_a: UBERON:0004347 ! limb bud is_a: UBERON:0005420 ! pelvic appendage bud intersection_of: UBERON:0004347 ! limb bud intersection_of: BFO:0000050 UBERON:0000154 ! part of posterior region of body intersection_of: RO:0002387 UBERON:0002103 ! has potential to develop into hindlimb relationship: RO:0002387 UBERON:0002103 ! has potential to develop into hindlimb [Term] id: UBERON:0005419 name: pectoral appendage bud def: "A limb bud that develops into a forelimb or pectoral fin." [OBOL:automatic] comment: at this time we have no need to name a more specific 'pectoral fin bud' class, but we may in future subset: efo_slim synonym: "forelimb - pectoral fin bud" EXACT [VHOG:0001754] synonym: "pectoral fin bud" RELATED [TAO:0000141] synonym: "pectoral fin buds" RELATED OMO:0003004 [TAO:0000141] xref: EFO:0003430 xref: TAO:0000141 xref: VHOG:0001754 xref: VHOG_RETIRED:0001259 xref: ZFA:0000141 is_a: UBERON:0004357 ! paired limb/fin bud intersection_of: UBERON:0004357 ! paired limb/fin bud intersection_of: RO:0002387 UBERON:0004710 ! has potential to develop into pectoral appendage relationship: BFO:0000050 UBERON:0000153 ! part of anterior region of body relationship: RO:0002254 UBERON:0005729 ! has developmental contribution from pectoral appendage field relationship: RO:0002387 UBERON:0004710 ! has potential to develop into pectoral appendage property_value: skos:prefLabel "pectoral appendage bud" xsd:string [Term] id: UBERON:0005420 name: pelvic appendage bud def: "A limb bud that develops into a hindlimb or pelvic fin." [OBOL:automatic] comment: at this time we have no need to name a more specific 'pelvic fin bud' class, but we may in future subset: efo_slim synonym: "hindlimb/pelvic fin bud" EXACT [VHOG:0001260] synonym: "pelvic fin bud" RELATED [TAO:0001384] synonym: "pelvic fin buds" RELATED OMO:0003004 [ZFA:0001384] xref: EFO:0003469 xref: TAO:0001384 xref: VHOG:0001260 xref: ZFA:0001384 is_a: UBERON:0004357 ! paired limb/fin bud intersection_of: UBERON:0004357 ! paired limb/fin bud intersection_of: BFO:0000050 UBERON:0000154 ! part of posterior region of body intersection_of: RO:0002387 UBERON:0004709 ! has potential to develop into pelvic appendage relationship: BFO:0000050 UBERON:0000154 ! part of posterior region of body relationship: RO:0002254 UBERON:0005730 ! has developmental contribution from pelvic appendage field relationship: RO:0002387 UBERON:0004709 ! has potential to develop into pelvic appendage property_value: RO:0002161 NCBITaxon:31033 {source="PMID:15893975"} [Term] id: UBERON:0005421 name: pectoral appendage apical ectodermal ridge def: "An apical ectodermal ridge that is part of a pectoral appendage bud." [OBOL:automatic] subset: efo_slim subset: vertebrate_core synonym: "AER forelimb" NARROW [VHOG:0001064] synonym: "aer pectoral fin" RELATED [TAO:0000085] synonym: "apical ectodermal ridge forelimb" NARROW [VHOG:0001064] synonym: "apical ectodermal ridge pectoral fin" RELATED [TAO:0000085] synonym: "apical ectodermal ridge pectoral fin bud" NARROW [ZFA:0000085] synonym: "apical fold pectoral fin" RELATED [TAO:0000085] synonym: "upper limb bud apical ectodermal ridge" NARROW [EHDAA2:0000138] synonym: "wing AER" NARROW SENSU [Giesha:syn] synonym: "wing apical ectodermal ridge" NARROW SENSU [] xref: EFO:0003487 xref: EHDAA2:0000138 xref: EMAPA:16778 xref: TAO:0000085 xref: TAO:0000736 xref: VHOG:0001064 xref: ZFA:0000085 is_a: UBERON:0004356 ! apical ectodermal ridge intersection_of: UBERON:0004356 ! apical ectodermal ridge intersection_of: BFO:0000050 UBERON:0005419 ! part of pectoral appendage bud relationship: BFO:0000050 UBERON:0005419 ! part of pectoral appendage bud relationship: RO:0002202 UBERON:0003372 {source="EHDAA2"} ! develops from pectoral appendage bud ectoderm property_value: skos:prefLabel "pectoral appendage apical ectodermal ridge" xsd:string [Term] id: UBERON:0005422 name: pelvic appendage apical ectodermal ridge def: "An apical ectodermal ridge that is part of a pelvic appendage bud." [OBOL:automatic] subset: efo_slim subset: vertebrate_core synonym: "AER hindlimb" RELATED [VHOG:0001066] synonym: "apical ectodermal ridge hind limb" NARROW [VHOG:0001066] synonym: "apical ectodermal ridge hindlimb" NARROW [VHOG:0001066] synonym: "apical ectodermal ridge pelvic fin bud" RELATED [TAO:0001385] synonym: "leg AER" RELATED [] synonym: "lower lmb bud apical ectodermal ridge" NARROW [EHDAA2:0003194] xref: EFO:0003681 xref: EHDAA2:0003194 xref: EMAPA:16892 xref: TAO:0001385 xref: VHOG:0001066 xref: ZFA:0001385 is_a: UBERON:0004356 ! apical ectodermal ridge intersection_of: UBERON:0004356 ! apical ectodermal ridge intersection_of: BFO:0000050 UBERON:0005420 ! part of pelvic appendage bud relationship: BFO:0000050 UBERON:0005420 ! part of pelvic appendage bud relationship: RO:0002202 UBERON:0003371 {source="EHDAA2"} ! develops from pelvic appendage bud ectoderm [Term] id: UBERON:0005423 name: developing anatomical structure subset: common_anatomy synonym: "developing structure" RELATED [] synonym: "developmental structure" RELATED [] synonym: "developmental tissue" RELATED [MIAA:0000019] xref: AEO:0000125 xref: CALOHA:TS-2122 xref: EHDAA2:0003125 xref: FBbt:00007006 {sssom:mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"} xref: FMA:292313 xref: MIAA:0000019 is_a: BFO:0000004 is_a: UBERON:0000465 ! material anatomical entity relationship: RO:0002215 GO:0032502 ! capable of developmental process property_value: RO:0002175 NCBITaxon:33090 property_value: RO:0002175 NCBITaxon:33208 property_value: RO:0002175 NCBITaxon:4751 property_value: skos:prefLabel "developing anatomical structure" xsd:string [Term] id: UBERON:0005424 name: presumptive retinal pigmented epithelium def: "Portion of tissue that is the outer layer of the optic cup and will become the retinal pigmented epithelium." [ZFIN:curator] subset: vertebrate_core synonym: "future pigmented layer" RELATED [EMAPA:16677] synonym: "future pigmented retinal epithelium" RELATED [EMAPA:16677] synonym: "future PRE" RELATED [EMAPA:16677] synonym: "future retinal pigmented epithelium" EXACT [] synonym: "future RPE" EXACT [] synonym: "optic cup outer layer" EXACT [EHDAA2:0001306] synonym: "outer layer optic cup" EXACT [ZFA:0000064] synonym: "presumptive pigmented epithelia" EXACT OMO:0003004 [ZFA:0000064] synonym: "presumptive pigmented epithelium" RELATED [TAO:0000064] xref: EHDAA2:0001306 xref: EMAPA:16677 xref: TAO:0000064 xref: VHOG:0000492 xref: ZFA:0000064 is_a: UBERON:0006598 ! presumptive structure intersection_of: UBERON:0006598 ! presumptive structure intersection_of: RO:0002387 UBERON:0001782 ! has potential to develop into pigmented layer of retina relationship: BFO:0000050 UBERON:0003072 ! part of optic cup relationship: RO:0002387 UBERON:0001782 ! has potential to develop into pigmented layer of retina [Term] id: UBERON:0005425 name: presumptive neural retina def: "Portion of tissue that is the inner layer of the optic cup and will become the neural retina." [ZFIN:curator] subset: vertebrate_core synonym: "future neural epithelium" RELATED [EMAPA:16675] synonym: "future neural layer" RELATED [EMAPA:16675] synonym: "future neural retina" EXACT [] synonym: "future NR" RELATED [] synonym: "future retinal neural layer" EXACT [] synonym: "inner layer optic cup" EXACT [ZFA:0001071] synonym: "optic cup inner layer" EXACT [EHDAA2:0001304] synonym: "presumptive retina" RELATED [TAO:0001071] synonym: "presumptive retinas" EXACT OMO:0003004 [ZFA:0001071] xref: EHDAA2:0001304 xref: EMAPA:16675 xref: TAO:0001071 xref: VHOG:0000490 xref: ZFA:0001071 is_a: UBERON:0006598 ! presumptive structure intersection_of: UBERON:0006598 ! presumptive structure intersection_of: RO:0002387 UBERON:0003902 ! has potential to develop into retinal neural layer relationship: BFO:0000050 UBERON:0003072 ! part of optic cup relationship: RO:0002387 UBERON:0003902 ! has potential to develop into retinal neural layer property_value: skos:prefLabel "presumptive neural retina" xsd:string [Term] id: UBERON:0005426 name: lens vesicle def: "Portion of tissue that gives rise to the lens." [https://sourceforge.net/tracker/?func=detail&atid=994726&aid=3514998&group_id=76834, ZFIN:curator] subset: pheno_slim subset: vertebrate_core synonym: "hollow lens vesicle" NARROW SENSU [] synonym: "immature lens" RELATED [ZFA:0001679] synonym: "lens mass" RELATED [ZFA:0001679, ZFIN:ZDB-PUB-091023-49] synonym: "presumptive lens" RELATED [ZFA:0001679] synonym: "solid lens vesicle" NARROW SENSU [ZFA:0001679] xref: EHDAA2:0000983 xref: EHDAA:4737 xref: EMAPA:17163 xref: SCTID:361510002 xref: TAO:0002205 xref: VHOG:0001163 xref: ZFA:0001679 is_a: BFO:0000002 is_a: UBERON:0000479 ! tissue relationship: RO:0002202 UBERON:0003073 ! develops from lens placode property_value: skos:prefLabel "lens vesicle" xsd:string [Term] id: UBERON:0005427 name: corneal primordium def: "Portion of tissue that is part of the eye and gives rise to the mature, fully layered cornea." [ZFIN:ZDB-PUB-061010-3] xref: TAO:0002188 xref: ZFA:0001688 is_a: UBERON:0000479 {source="ZFA"} ! tissue is_a: UBERON:0001048 {source="Obol"} ! primordium is_a: UBERON:0010313 ! neural crest-derived structure relationship: BFO:0000050 UBERON:0000019 {source="ZFA"} ! part of camera-type eye property_value: skos:prefLabel "corneal primordium" xsd:string [Term] id: UBERON:0005428 name: vagal neural crest def: "Vagal neural crest is adjacent to the first seven somites gives rise to both ganglionic and ectomesenchymal derivatives[ZFA]." [ZFIN:curator] subset: vertebrate_core synonym: "enteric neural crest" RELATED [] synonym: "post-otic neural crest" RELATED [ZFA:0000818] synonym: "VNC" EXACT OMO:0003000 [XAO:0004191] xref: EHDAA2:0002156 xref: EHDAA:669 xref: TAO:0000818 xref: VHOG:0001208 xref: XAO:0004191 xref: ZFA:0000818 is_a: UBERON:0005291 ! embryonic tissue relationship: BFO:0000050 UBERON:0002342 ! part of neural crest property_value: skos:prefLabel "vagal neural crest" xsd:string [Term] id: UBERON:0005432 name: aortic sac def: "The dilated structure that is lined by endothelial cells and located at the arterial pole of the heart just above (distal to) the truncus arteriosus in mammalian embryos; it is the primordial vascular channel from which the aortic arches (and eventually the dorsal aortae) arise; the aortic sac is homologous to the ventral aorta of gill-bearing vertebrates." [MP:0012510] subset: pheno_slim synonym: "saccus aorticus" EXACT OMO:0003011 [] xref: EHDAA2:0004145 xref: EHDAA:9826 xref: EMAPA:36461 xref: FMA:71008 xref: RETIRED_EHDAA2:0000133 xref: SCTID:361527005 is_a: UBERON:0001637 {source="EHDAA2"} ! artery is_a: UBERON:0002050 ! embryonic structure is_a: UBERON:0003498 ! heart blood vessel relationship: BFO:0000050 UBERON:0004145 ! part of outflow tract relationship: RO:0002202 UBERON:0004363 {source="EHDAA2"} ! develops from pharyngeal arch artery property_value: skos:prefLabel "aortic sac" xsd:string [Term] id: UBERON:0005434 name: cervical region synonym: "cervical region" EXACT [FMA:24219] synonym: "neck subdivision" EXACT [FMA:24219] synonym: "region of neck" EXACT [FMA:24219] synonym: "subdivision of neck" EXACT [FMA:24219] xref: FMA:24219 xref: SCTID:123958008 is_a: UBERON:0011676 ! subdivision of organism along main body axis relationship: BFO:0000050 UBERON:0000974 ! part of neck relationship: RO:0002162 NCBITaxon:8287 ! in taxon Sarcopterygii property_value: skos:prefLabel "cervical region" xsd:string [Term] id: UBERON:0005436 name: common hepatic artery def: "In anatomy, the common hepatic artery is a short blood vessel that supplies oxygenated blood to the liver, pylorus (a part of the stomach), duodenum (a part of the small intestine), pancreas, and gall bladder. It arises from the celiac artery and has the following branches: the hepatic artery proper, the gastroduodenal artery and the right gastric artery." [https://www.elsevier.com/resources/anatomy/cardiovascular-system/arteries/common-hepatic-artery/22763, Wikipedia:Common_hepatic_artery] subset: human_reference_atlas synonym: "arteria hepatica communis" RELATED OMO:0003011 [Wikipedia:Common_hepatic_artery] synonym: "common hepatic" RELATED [Wikipedia:Common_hepatic_artery] xref: EHDAA2:0000308 xref: EHDAA:8570 xref: EMAPA:37206 {source="MA:th"} xref: FMA:14771 xref: galen:CommonHepaticArtery xref: MA:0003094 xref: SCTID:244263001 xref: Wikipedia:Common_hepatic_artery is_a: UBERON:0004573 ! systemic artery relationship: RO:0002252 UBERON:0001640 ! connecting branch of celiac artery property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/6/65/Gray532.png" xsd:anyURI property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/blood-vasculature-female/v1.3/assets/3d-vh-f-blood-vasculature.glb" xsd:anyURI property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/blood-vasculature-male/v1.3/assets/3d-vh-m-blood-vasculature.glb" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "common hepatic artery" xsd:string [Term] id: UBERON:0005445 name: segment of pes def: "A segment of autopod that is part of a pes." [OBOL:automatic] subset: pheno_slim synonym: "foot region" BROAD [FMA:24993] synonym: "foot subdivision" EXACT [FMA:24993] synonym: "regio pedis" EXACT OMO:0003011 [FMA:24993, FMA:TA] synonym: "segment of foot" EXACT [FMA:24993] synonym: "subdivision of foot" EXACT [FMA:24993] xref: FMA:24993 xref: SCTID:362887000 is_a: UBERON:0008784 ! lower limb segment is_a: UBERON:0012139 ! segment of autopod intersection_of: UBERON:0012139 ! segment of autopod intersection_of: BFO:0000050 UBERON:0002387 ! part of pes relationship: BFO:0000050 UBERON:0002387 ! part of pes [Term] id: UBERON:0005446 name: foramen rotundum def: "The foramen rotundum is a circular hole in the sphenoid bone that connects the middle cranial fossa and the pterygopalatine fossa." [Wikipedia:Foramen_rotundum] synonym: "foramen rotundum of the skull" RELATED [Wikipedia:Foramen_rotundum] synonym: "foramen rotundum ossis sphenoidalis" RELATED OMO:0003011 [Wikipedia:Foramen_rotundum] synonym: "round foramen" RELATED [VHOG:0001543] xref: AAO:0000194 xref: EHDAA2:0000552 xref: EHDAA:10629 xref: EMAPA:18712 xref: FMA:53154 xref: SCTID:369439002 xref: VHOG:0001543 xref: Wikipedia:Foramen_rotundum is_a: UBERON:0013685 ! foramen of skull intersection_of: UBERON:0013685 ! foramen of skull intersection_of: BFO:0000050 UBERON:0001677 ! part of sphenoid bone intersection_of: RO:0002570 UBERON:0000377 ! conduit for maxillary nerve relationship: BFO:0000050 UBERON:0001677 ! part of sphenoid bone relationship: RO:0002570 UBERON:0000377 ! conduit for maxillary nerve property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/3/35/Gray145.png" xsd:anyURI property_value: skos:prefLabel "foramen rotundum" xsd:string [Term] id: UBERON:0005451 name: segment of manus def: "A segment of autopod that is part of a manus." [OBOL:automatic] subset: pheno_slim synonym: "hand region" BROAD [FMA:24945] synonym: "hand subdivision" EXACT [FMA:24945] synonym: "regio manus" EXACT OMO:0003011 [] synonym: "segment of hand" EXACT [FMA:24945] synonym: "subdivision of hand" EXACT [FMA:24945] xref: FMA:24945 xref: SCTID:127950000 is_a: UBERON:0008785 ! upper limb segment is_a: UBERON:0012139 ! segment of autopod intersection_of: UBERON:0012139 ! segment of autopod intersection_of: BFO:0000050 UBERON:0002398 ! part of manus relationship: BFO:0000050 UBERON:0002398 ! part of manus [Term] id: UBERON:0005453 name: inferior mesenteric ganglion def: "A ganglion located near where the inferior mesenteric artery branches from the abdominal aorta[WP]." [Wikipedia:Inferior_mesenteric_ganglion] subset: human_reference_atlas synonym: "ganglion mesentericum inferius" RELATED OMO:0003011 [Wikipedia:Inferior_mesenteric_ganglion] xref: BAMS:GIM xref: EHDAA2:0000818 xref: EHDAA:8948 xref: FMA:77590 xref: MA:0003103 xref: SCTID:279277007 xref: Wikipedia:Inferior_mesenteric_ganglion is_a: UBERON:0035769 ! mesenteric ganglion intersection_of: UBERON:0003964 ! prevertebral ganglion intersection_of: BFO:0000050 UBERON:0035770 ! part of inferior mesenteric nerve plexus relationship: BFO:0000050 UBERON:0035770 ! part of inferior mesenteric nerve plexus property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/6/63/Gray848.png" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0005456 name: jugular foramen def: "The jugular foramen is a large aperture in the base of the skull. It is located behind the carotid canal and is formed in front by the petrous portion of the temporal, and behind by the occipital; it is generally larger on the right than on the left side." [Wikipedia:Jugular_foramen] synonym: "foramen jugulare" RELATED [Wikipedia:Jugular_foramen] synonym: "Posterior lacerate foramen" EXACT [FMA:56432] xref: AAO:0000249 xref: EHDAA2:0000893 xref: EHDAA:10631 xref: EMAPA:18713 xref: FMA:56432 xref: NCIT:C12496 xref: SCTID:361735006 xref: UMLS:C0222712 {source="ncithesaurus:Jugular_Foramen"} xref: VHOG:0001113 xref: Wikipedia:Jugular_foramen is_a: UBERON:0018321 ! foramen for glossopharyngeal nerve intersection_of: UBERON:0013685 ! foramen of skull intersection_of: BFO:0000050 UBERON:0001678 ! part of temporal bone intersection_of: RO:0002570 UBERON:0001586 ! conduit for internal jugular vein relationship: BFO:0000050 UBERON:0001678 ! part of temporal bone relationship: RO:0002570 UBERON:0001586 ! conduit for internal jugular vein relationship: RO:0002570 UBERON:0001759 ! conduit for vagus nerve relationship: RO:0002570 UBERON:0002019 ! conduit for accessory XI nerve property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/f/fa/Foramenjugulare.PNG" xsd:anyURI property_value: skos:prefLabel "jugular foramen" xsd:string [Term] id: UBERON:0005457 name: left thymus lobe def: "A thymus lobe that is in the left side of a thymus." [OBOL:automatic] synonym: "left lobe of thymus" EXACT [FMA:71195] synonym: "left thymic lobe" EXACT [FMA:71195] xref: FMA:71195 xref: RETIRED_EHDAA2:0000964 xref: SCTID:188079002 is_a: UBERON:0005483 ! thymus lobe intersection_of: UBERON:0005483 ! thymus lobe intersection_of: BSPO:0000120 UBERON:0002370 ! thymus relationship: BSPO:0000120 UBERON:0002370 ! thymus property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/thymus-female/v1.3/assets/3d-vh-f-thymus.glb" xsd:anyURI property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/thymus-male/v1.3/assets/3d-vh-m-thymus.glb" xsd:anyURI [Term] id: UBERON:0005458 name: left umbilical artery synonym: "embryonic left umbilical artery" EXACT [VHOG:0000522] xref: EHDAA2:0000966 xref: EMAPA:16544 xref: FMA:18822 xref: VHOG:0000522 is_a: UBERON:0001310 ! umbilical artery relationship: RO:0002202 UBERON:0005613 ! develops from left dorsal aorta relationship: RO:0002202 UBERON:0011696 ! develops from left extraembryonic umbilical artery [Term] id: UBERON:0005459 name: left umbilical vein def: "An umbilical vein that is in the left side of a multicellular organism." [OBOL:automatic] xref: EHDAA2:0000967 xref: EMAPA:16358 xref: EMAPA:16377 xref: FMA:70320 xref: SCTID:308833008 is_a: UBERON:0002066 ! umbilical vein is_a: UBERON:0015212 ! lateral structure intersection_of: UBERON:0002066 ! umbilical vein intersection_of: BSPO:0000120 UBERON:0000468 ! multicellular organism relationship: BSPO:0000120 UBERON:0000468 ! multicellular organism [Term] id: UBERON:0005460 name: left vitelline vein def: "A vitelline vein that is in the left side of a multicellular organism." [OBOL:automatic] xref: EHDAA2:0000971 xref: EMAPA:16380 xref: EMAPA:16698 xref: FMA:70307 xref: SCTID:361446008 is_a: UBERON:0005487 ! vitelline vein is_a: UBERON:0015212 ! lateral structure intersection_of: UBERON:0005487 ! vitelline vein intersection_of: BSPO:0000120 UBERON:0000468 ! multicellular organism relationship: BSPO:0000120 UBERON:0000468 ! multicellular organism property_value: skos:prefLabel "left vitelline vein" xsd:string [Term] id: UBERON:0005461 name: levator scapulae muscle def: "An axial muscle that originates in the cervical vertebraae inserts on the scapula." [http://orcid.org/0000-0002-6601-2165] comment: Axial muscle group[Kardong] subset: human_reference_atlas subset: pheno_slim synonym: "levator scapula" RELATED [Wikipedia:Levator_scapulae_muscle] synonym: "levator scapulae" EXACT [FMA:32519] synonym: "levator scapulae muscle" RELATED [Wikipedia:Levator_scapulae_muscle] synonym: "levator scapulæ" RELATED [Wikipedia:Levator_scapulae_muscle] synonym: "musculus levator scapulae" RELATED OMO:0003011 [Wikipedia:Levator_scapulae_muscle] xref: AAO:0010689 xref: EHDAA2:0000992 xref: EHDAA:8309 xref: FMA:32519 xref: SCTID:279236008 xref: Wikipedia:Levator_scapulae_muscle is_a: UBERON:0001482 ! muscle of shoulder is_a: UBERON:0004518 ! muscle of vertebral column is_a: UBERON:0034908 ! scapular muscle intersection_of: UBERON:0014892 ! skeletal muscle organ, vertebrate intersection_of: RO:0002371 UBERON:0002413 ! attached to cervical vertebra intersection_of: RO:0002371 UBERON:0006849 ! attached to scapula relationship: BFO:0000050 UBERON:0008713 {source="EHDAA2"} ! part of pectoral girdle and thoracic body wall skeletal muscle relationship: BFO:0000050 UBERON:0013700 {source="Kardong"} ! part of axial musculature relationship: RO:0002005 UBERON:0000962 ! innervated by nerve of cervical vertebra relationship: RO:0002202 UBERON:0010983 {source="EHDAA2"} ! develops from levator scapulae pre-muscle mass relationship: RO:0002371 UBERON:0002413 ! attached to cervical vertebra relationship: RO:0002372 UBERON:0001077 ! has muscle origin transverse process of vertebra relationship: RO:0002373 UBERON:0007174 ! has muscle insertion medial border of scapula property_value: foaf:depiction "https://upload.wikimedia.org/wikipedia/commons/b/bc/Levator_scapulae.png" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0005462 name: lower back def: "Subdivision of abdominal segment of trunk which in humans is demarcated from the front of the abdomen by the posterior surface of the anterior layer of the thoracolumbar fascia and the anterior surface of the lumbar vertebral column; together with the front of the abdomen, it constitutes the abdomen[Modified from FMA]." [FMA:61681] comment: overlaps with region sometimes called 'loin' synonym: "abdominal back" EXACT [FMA:61681] synonym: "back of abdomen" EXACT [FMA:61681] synonym: "dorsum of abdomen" EXACT [FMA:61681] synonym: "loin" RELATED [BTO:0001505, Wikipedia:Loin] synonym: "lombus" RELATED [] synonym: "lower back" EXACT [MA:0000027] synonym: "lumbar part of back" EXACT [FMA:61681] synonym: "lumbar region" BROAD [FMA:61681] synonym: "lumbar region of back" EXACT [https://orcid.org/0000-0002-6601-2165] synonym: "lumbos" RELATED [] synonym: "posterior part of abdomen" EXACT [FMA:61681] synonym: "regio lumbalis" EXACT OMO:0003011 [FMA:61681, FMA:TA] xref: BTO:0001505 xref: EMAPA:36623 xref: FMA:61681 xref: MA:0000027 xref: NCIT:C34004 xref: SCTID:182343007 xref: UMLS:C0024090 {source="ncithesaurus:Lumbar_Region"} is_a: UBERON:0009569 ! subdivision of trunk relationship: BFO:0000050 UBERON:0001137 ! part of dorsum relationship: BFO:0000050 UBERON:0002417 {source="MA"} ! part of abdominal segment of trunk [Term] id: UBERON:0005463 name: subcapsular sinus of lymph node def: "A space between the capsule and the cortex which allows the free movement of lymphatic fluid and so contains a sparsity of lymphocytes. It is continuous with the similar lymph sinuses that flank the trabeculae." [Wikipedia:Lymph_node#Subcapsular_sinus] subset: human_reference_atlas synonym: "lymph node subcortical sinus" EXACT [MA:0003027] synonym: "lymph path" RELATED [Wikipedia:Subcapsular_sinus] synonym: "lymph sinus" RELATED [Wikipedia:Subcapsular_sinus] synonym: "marginal sinus" BROAD [Wikipedia:Subcapsular_sinus] synonym: "marginal sinus of lymph node" RELATED [Wikipedia:Subcapsular_sinus] synonym: "subcapsular sinus" RELATED [Wikipedia:Subcapsular_sinus] xref: EMAPA:37662 {source="MA:th"} xref: FMA:312355 xref: MA:0003027 xref: NCIT:C33033 xref: NCIT:C33642 xref: UMLS:C1518051 {source="ncithesaurus:Lymph_Node_Sinus"} xref: UMLS:C1518052 {source="ncithesaurus:Lymph_Node_Subcapsular_Sinus"} xref: Wikipedia:Subcapsular_sinus is_a: UBERON:0000464 ! anatomical space intersection_of: UBERON:0000464 ! anatomical space intersection_of: BFO:0000050 UBERON:0000029 ! part of lymph node intersection_of: RO:0002220 UBERON:0002006 ! adjacent to cortex of lymph node intersection_of: RO:0002220 UBERON:0002194 ! adjacent to capsule of lymph node relationship: BFO:0000050 UBERON:0000029 ! part of lymph node relationship: RO:0002220 UBERON:0002006 ! adjacent to cortex of lymph node relationship: RO:0002220 UBERON:0002194 ! adjacent to capsule of lymph node property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/6/68/Gray597.png" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0005469 name: right thymus lobe def: "A thymus lobe that is in the right side of a thymus." [OBOL:automatic] synonym: "right lobe of thymus" EXACT [FMA:71194] synonym: "right thymic lobe" EXACT [FMA:71194] xref: FMA:71194 xref: RETIRED_EHDAA2:0001758 xref: SCTID:187981000 is_a: UBERON:0005483 ! thymus lobe intersection_of: UBERON:0005483 ! thymus lobe intersection_of: BSPO:0000121 UBERON:0002370 ! thymus relationship: BSPO:0000121 UBERON:0002370 ! thymus property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/thymus-female/v1.3/assets/3d-vh-f-thymus.glb" xsd:anyURI property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/thymus-male/v1.3/assets/3d-vh-m-thymus.glb" xsd:anyURI [Term] id: UBERON:0005470 name: right umbilical artery synonym: "embryonic right umbilical artery" EXACT [VHOG:0000523] xref: EHDAA2:0001760 xref: EMAPA:16545 xref: FMA:18821 xref: VHOG:0000523 is_a: UBERON:0001310 ! umbilical artery relationship: RO:0002202 UBERON:0005622 ! develops from right dorsal aorta relationship: RO:0002202 UBERON:0011697 ! develops from right extraembryonic umbilical artery [Term] id: UBERON:0005471 name: right umbilical vein def: "An umbilical vein that is in the right side of a multicellular organism." [OBOL:automatic] xref: EHDAA2:0001761 xref: EMAPA:16359 xref: EMAPA:16378 xref: FMA:70319 xref: SCTID:361447004 is_a: UBERON:0002066 ! umbilical vein is_a: UBERON:0015212 ! lateral structure intersection_of: UBERON:0002066 ! umbilical vein intersection_of: BSPO:0000121 UBERON:0000468 ! multicellular organism relationship: BSPO:0000121 UBERON:0000468 ! multicellular organism [Term] id: UBERON:0005472 name: right vitelline vein def: "A vitelline vein that is in the right side of a multicellular organism." [OBOL:automatic] xref: EHDAA2:0001766 xref: EMAPA:16381 xref: EMAPA:16699 xref: FMA:70306 xref: SCTID:361445007 is_a: UBERON:0005487 ! vitelline vein is_a: UBERON:0015212 ! lateral structure intersection_of: UBERON:0005487 ! vitelline vein intersection_of: BSPO:0000121 UBERON:0000468 ! multicellular organism relationship: BSPO:0000121 UBERON:0000468 ! multicellular organism property_value: skos:prefLabel "right vitelline vein" xsd:string [Term] id: UBERON:0005473 name: sacral region def: "A subdivision of an organism along the anterior-posterior axis in the pelvic region immediately posterior to the lumbar region and anterior to the caudal region. Sometimes an intermediate region is defined between the sacral and caudal." [http://orcid.org/0000-0002-6601-2165] synonym: "back of pelvis" EXACT [FMA:24228] synonym: "croup" NARROW SENSU [Wikipedia:Rump_(animal)] synonym: "hindquarter" NARROW SENSU [Wikipedia:Rump_(animal)] synonym: "pelvic back" EXACT [FMA:24228] synonym: "posterior part of pelvis" EXACT [FMA:24228] synonym: "regio sacralis" EXACT OMO:0003011 [FMA:24228, FMA:TA] synonym: "rump" NARROW SENSU [Wikipedia:Rump_(animal)] synonym: "sacral part of pelvis" EXACT [FMA:24228] xref: FMA:24228 xref: SCTID:182344001 xref: Wikipedia:Sacrum is_a: UBERON:0011676 ! subdivision of organism along main body axis relationship: BFO:0000050 UBERON:0002355 ! part of pelvic region of trunk relationship: RO:0002551 UBERON:0006075 ! has skeleton sacral region of vertebral column [Term] id: UBERON:0005476 name: spinal nerve trunk def: "Trunk part of spinal nerve, where dorsal and ventral roots meet to form the spinal nerve, before branching off to dorsal and ventral rami." [http://orcid.org/0000-0002-6601-2165] subset: human_reference_atlas synonym: "spinal nerve (trunk)" EXACT [FMA:5929] synonym: "spinal neural trunk" EXACT [FMA:5929] synonym: "trunk of spinal nerve" EXACT [FMA:5929] xref: EHDAA2:0001900 xref: FMA:5929 is_a: UBERON:0002464 ! nerve trunk intersection_of: UBERON:0002464 ! nerve trunk intersection_of: BFO:0000050 UBERON:0001780 ! part of spinal nerve relationship: BFO:0000050 UBERON:0001780 ! part of spinal nerve property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0005477 name: stomach fundus epithelium def: "A simple columnar epithelium that is part of a fundus of stomach." [OBOL:automatic] synonym: "epithelium of fundus of stomach" EXACT [FMA:17277] synonym: "gastric epithelium of fundus" EXACT [FMA:17277] synonym: "gastric fundus epithelium" EXACT [FMA:17277] xref: EHDAA2:0001921 xref: EMAPA:17888 xref: FMA:17277 xref: VHOG:0000878 is_a: UBERON:0001276 ! epithelium of stomach intersection_of: UBERON:0000485 ! simple columnar epithelium intersection_of: BFO:0000050 UBERON:0001160 ! part of fundus of stomach relationship: BFO:0000050 UBERON:0004994 ! part of mucosa of fundus of stomach [Term] id: UBERON:0005478 name: sulcus limitans of neural tube def: "A longitudinal groove in the neural tube wall that divides the neural tube into dorsal (alar) and ventral (basal) halves (dorsal receives input from sensory neurons, ventral effects motor functions); stretches from the mesencephalon caudad[TMD]." [http://medical-dictionary.thefreedictionary.com/Sulcus+limitans, http://www.ncbi.nlm.nih.gov/books/NBK10047] synonym: "neural tube lateral wall sulcus limitans" EXACT [EHDAA2:0001265] synonym: "sulcus limitans" BROAD [] xref: BAMS:slim xref: BAMS:slm xref: neuronames:629 is_a: BFO:0000004 is_a: UBERON:0006846 ! surface groove relationship: BFO:0000050 UBERON:0005496 {source="EHDAA2"} ! part of neural tube lateral wall property_value: skos:prefLabel "sulcus limitans of neural tube" xsd:string [Term] id: UBERON:0005479 name: superior mesenteric ganglion def: "A ganglion in the upper part of the superior mesenteric plexus that is the synapsing point for one of the pre- and post-synaptic nerves of the sympathetic division of the autonomous nervous system." [Wikipedia:Superior_mesenteric_ganglion] subset: human_reference_atlas synonym: "ganglion mesentericum superius" RELATED OMO:0003011 [Wikipedia:Superior_mesenteric_ganglion] synonym: "superior mesenteric ganglia" RELATED [Wikipedia:Superior_mesenteric_ganglion] xref: BAMS:GSM xref: EHDAA2:0001950 xref: EHDAA:8950 xref: FMA:77589 xref: MA:0003102 xref: SCTID:279276003 xref: Wikipedia:Superior_mesenteric_ganglion is_a: UBERON:0035769 ! mesenteric ganglion intersection_of: UBERON:0003964 ! prevertebral ganglion intersection_of: BFO:0000050 UBERON:0005488 ! part of superior mesenteric plexus relationship: BFO:0000050 UBERON:0005488 ! part of superior mesenteric plexus property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/f/f7/Gray839.png" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0005483 name: thymus lobe def: "Either of the two lateral lobes that constitute the thymus." [http://orcid.org/0000-0002-6601-2165] subset: human_reference_atlas synonym: "lateral lobe of thymus" EXACT [http://orcid.org/0000-0002-6601-2165] synonym: "lobe of thymus" EXACT [FMA:71193] synonym: "thymus subunit" EXACT [] xref: FMA:71193 xref: RETIRED_EHDAA2:0002021 is_a: UBERON:0009912 ! anatomical lobe is_a: UBERON:0015212 ! lateral structure intersection_of: UBERON:0009912 ! anatomical lobe intersection_of: BFO:0000050 UBERON:0002370 ! part of thymus relationship: BFO:0000050 UBERON:0002370 ! part of thymus relationship: BSPO:0000126 UBERON:0002370 {source="FMA-abduced-lr"} ! thymus property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0005486 name: venous dural sinus def: "A venous channel found between layers of dura mater in the brain. Receives blood from internal and external veins of the brain, receive cerebrospinal fluid (CSF) from the subarachnoid space, and ultimately empty into the internal jugular vein." [Wikipedia:Dural_venous_sinuses] synonym: "cranial dural venous sinus" EXACT [FMA:50762] synonym: "dural sinus" EXACT [FMA:50762] synonym: "dural vein" EXACT [MA:0002113] synonym: "dural venous sinus" EXACT [FMA:50762] synonym: "s. durae matris" RELATED OMO:0003011 [Wikipedia:Dural_venous_sinuses] synonym: "venous dural" EXACT [EHDAA:6491] synonym: "venous dural sinus" EXACT [EHDAA2:0002169] xref: EHDAA2:0002169 xref: EHDAA:6491 xref: EMAPA:18634 xref: FMA:50762 xref: MA:0002113 xref: NCIT:C102627 xref: SCTID:54944003 xref: VHOG:0001004 xref: Wikipedia:Dural_venous_sinuses is_a: UBERON:0006615 ! venous sinus intersection_of: UBERON:0006615 ! venous sinus intersection_of: RO:0001025 UBERON:0002363 ! located in dura mater relationship: BFO:0000050 UBERON:0003711 {source="FMA"} ! part of brachiocephalic vein relationship: BFO:0000050 UBERON:0010743 ! part of meningeal cluster relationship: RO:0001025 UBERON:0002363 ! located in dura mater property_value: foaf:depiction "https://upload.wikimedia.org/wikipedia/commons/b/bd/Gray488_blue.gif" xsd:anyURI property_value: IAO:0000116 "the MA placement should be checked" xsd:string [Term] id: UBERON:0005487 name: vitelline vein def: "The paired veins that carry blood from the yolk sac back to the embryo." [MGI:csmith, MP:0010666] subset: pheno_slim subset: vertebrate_core synonym: "embryonic vitelline vein" EXACT [VHOG:0000401] synonym: "omphalomesenteric vein" RELATED [EMAPA:16244] synonym: "vascular vitelline network" EXACT [XAO:0004147] synonym: "vein of omphalomesenteric system" RELATED [] synonym: "vena vitellina" EXACT OMO:0003011 [Wikipedia:Vitelline_veins] synonym: "vitelline veins" RELATED OMO:0003004 [XAO:0004147] xref: EMAPA:36021 xref: FMA:70305 xref: NCIT:C34329 xref: RETIRED_EHDAA2:0002209 xref: SCTID:2730004 xref: SCTID:308832003 xref: UMLS:C0231091 {source="ncithesaurus:Vitelline_Vein"} xref: VHOG:0000401 xref: Wikipedia:Vitelline_veins xref: XAO:0000376 xref: XAO:0004147 is_a: UBERON:0004365 ! vitelline blood vessel is_a: UBERON:0013140 ! systemic vein intersection_of: UBERON:0001638 ! vein intersection_of: RO:0020102 UBERON:0001040 ! vessel drains blood from yolk sac relationship: RO:0020102 UBERON:0001040 ! vessel drains blood from yolk sac property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/7/7e/Gray475.png" xsd:anyURI property_value: skos:prefLabel "vitelline vein" xsd:string [Term] id: UBERON:0005488 name: superior mesenteric plexus def: "The superior mesenteric plexus is a continuation of the lower part of the celiac plexus, receiving a branch from the junction of the right vagus nerve with the plexus. It surrounds the superior mesenteric artery, accompanies it into the mesentery, and divides into a number of secondary plexuses, which are distributed to all the parts supplied by the artery, viz. , pancreatic branches to the pancreas; intestinal branches to the small intestine; and ileocolic, right colic, and middle colic branches, which supply the corresponding parts of the great intestine. The nerves composing this plexus are white in color and firm in texture; in the upper part of the plexus close to the origin of the superior mesenteric artery is the superior mesenteric ganglion." [Wikipedia:Superior_mesenteric_plexus] subset: human_reference_atlas synonym: "plexus mesentericus superior" EXACT OMO:0003011 [Wikipedia:Superior_mesenteric_plexus] synonym: "superior mesenteric nerve plexus" EXACT [FMA:6639] xref: FMA:6639 xref: SCTID:362493003 xref: Wikipedia:Superior_mesenteric_plexus is_a: UBERON:0000122 ! neuron projection bundle is_a: UBERON:0035771 ! mesenteric plexus intersection_of: UBERON:0035771 ! mesenteric plexus intersection_of: extends_fibers_into UBERON:0002010 ! celiac nerve plexus intersection_of: RO:0002134 UBERON:0000059 ! innervates large intestine relationship: extends_fibers_into UBERON:0002010 ! celiac nerve plexus relationship: RO:0002134 UBERON:0000059 ! innervates large intestine property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/6/63/Gray848.png" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0005491 name: glossopharyngeal neural crest def: "Cranial neural crest which gives rise to the glossopharyngeal ganglion." [ZFA:0007066] subset: vertebrate_core xref: EHDAA2:0000714 xref: EHDAA:660 xref: TAO:0007066 xref: ZFA:0007066 is_a: UBERON:0003099 ! cranial neural crest property_value: skos:prefLabel "glossopharyngeal neural crest" xsd:string [Term] id: UBERON:0005496 name: neural tube lateral wall def: "Portion of tissue on the side of the lumen of the neural tube." [ZFA:0001435] subset: vertebrate_core synonym: "lateral wall neural tube" EXACT [ZFA:0001435] xref: EHDAA2:0001257 xref: EHDAA:2873 xref: EHDAA:912 xref: EMAPA:16166 xref: TAO:0001435 xref: VHOG:0000513 xref: ZFA:0001435 is_a: UBERON:0000061 ! anatomical structure relationship: BFO:0000050 UBERON:0001049 ! part of neural tube property_value: skos:prefLabel "neural tube lateral wall" xsd:string [Term] id: UBERON:0005497 name: non-neural ectoderm comment: Gene notes: One of the first genes to be expressed in nonneural ectoderm in amphioxus is BMP2/4 (Panopoulou et al. 1998). BMP2/4 homologues appear to have a very ancient role in distinguishing neural from nonneural ectoderm; in Drosophila as well as in amphioxus and vertebrates, BMP2/4 homologues are expressed in nonneural ectoderm and function in distinguishing neural from nonneural ectoderm (Francois & Bier, 1995 ; Sasai et al. 1995 ; Wilson & Hemmati-Brivanlou, 1995; Panopoulou et al. 1998). A change in level of BMP2/4 from very high in nonneural ectoderm to low in neural ectoderm appears to be a key factor in development of neural crest (Baker & Bronner-Fraser,1997a,1997b;Erickson&Reedy,1998;Marchantet al.1998 ;Selleck et al. 1998). subset: efo_slim subset: vertebrate_core synonym: "epidermal ectoderm" NARROW [https://github.com/obophenotype/uberon/wiki/The-neural-crest] synonym: "epithelial ectoderm" NARROW [https://github.com/obophenotype/uberon/wiki/The-neural-crest] synonym: "non neural ectoderm" EXACT [ZFA:0001178] synonym: "surface ectoderm" RELATED [https://github.com/obophenotype/uberon/wiki/The-neural-crest] synonym: "ventral ectoderm" RELATED [ZFA:0001178] xref: EFO:0003643 xref: EHDAA:257 xref: EMAPA:16074 xref: RETIRED_EHDAA2:0001273 xref: TAO:0001178 xref: VHOG:0001372 xref: XAO:0004091 xref: ZFA:0001178 is_a: UBERON:0000479 {source="ZFA"} ! tissue is_a: UBERON:0004121 ! ectoderm-derived structure property_value: IAO:0000116 "todo - epidermis? todo - track down EHDAA2 class in new release" xsd:string property_value: skos:prefLabel "non-neural ectoderm" xsd:string [Term] id: UBERON:0005498 name: primitive heart tube def: "Multi-tissue structure that arises from the heart rudiment and will become the heart tube." [ZFA:0000149] subset: vertebrate_core synonym: "early primitive heart tube" NARROW [EMAPA:16208] synonym: "primitive heart tube" EXACT [EMAPA:16215] xref: EHDAA2:0001512 xref: EHDAA:424 xref: EHDAA:436 xref: EMAPA:16215 xref: FMA:321916 xref: SCTID:361522004 xref: TAO:0000149 xref: Wikipedia:Primitive_heart_tube xref: ZFA:0000149 is_a: UBERON:0000481 ! multi-tissue structure is_a: UBERON:0004120 ! mesoderm-derived structure relationship: BFO:0000050 UBERON:0000922 ! part of embryo relationship: RO:0002202 UBERON:0004291 {source="ZFA"} ! develops from heart rudiment property_value: skos:prefLabel "primitive heart tube" xsd:string [Term] id: UBERON:0005499 name: rhombomere 1 def: "Hindbrain segment or neuromere 1." [ZFA:0001031] subset: efo_slim subset: pheno_slim subset: vertebrate_core synonym: "r1" EXACT OMO:0003000 [ZFA:0001031] xref: DHBA:12667 xref: DMBA:16915 xref: EFO:0003608 xref: EHDAA2:0001637 xref: EMAPA:16290 xref: FMA:295790 xref: TAO:0001031 xref: ZFA:0001031 is_a: BFO:0000002 is_a: UBERON:0001892 ! rhombomere relationship: RO:0002202 UBERON:0007289 {evidence="definitional"} ! develops from presumptive rhombomere 1 property_value: skos:prefLabel "rhombomere 1" xsd:string [Term] id: UBERON:0005501 name: rhombomere lateral wall def: "A neural tube lateral wall that is part of a rhombomere." [OBOL:automatic] synonym: "future hindbrain lateral wall" RELATED [EMAPA:35364] xref: EMAPA:32819 xref: EMAPA:35364 is_a: UBERON:0005496 ! neural tube lateral wall intersection_of: UBERON:0005496 ! neural tube lateral wall intersection_of: BFO:0000050 UBERON:0001892 ! part of rhombomere relationship: BFO:0000050 UBERON:0001892 ! part of rhombomere property_value: skos:prefLabel "rhombomere lateral wall" xsd:string [Term] id: UBERON:0005502 name: rhombomere roof plate synonym: "future hindbrain roof plate" RELATED [EMAPA:35367] synonym: "roof plate hindbrain" RELATED [ZFA:0001311] synonym: "roof plate rhombomere" EXACT [TAO:0001311] synonym: "roof plate rhombomere region" EXACT [ZFA:0001311] synonym: "roof plate rhombomeres" EXACT [VHOG:0001018] xref: EMAPA:32824 xref: EMAPA:35367 xref: TAO:0001311 xref: VHOG:0001018 xref: ZFA:0001311 is_a: UBERON:0003054 ! roof plate intersection_of: UBERON:0003054 ! roof plate intersection_of: BFO:0000050 UBERON:0001892 ! part of rhombomere relationship: BFO:0000050 UBERON:0001892 ! part of rhombomere property_value: skos:prefLabel "rhombomere roof plate" xsd:string [Term] id: UBERON:0005562 name: thymus primordium def: "A small outgrowth of the pharyngeal epithelium that is the site of lymphocyte cell production[ZFA]. [PMID]." [ZFA:0001077] subset: efo_slim subset: vertebrate_core synonym: "thymic primordium" EXACT [OBOL:automatic] synonym: "thymic rudiment" EXACT [ZFA:0001077] xref: EFO:0003622 xref: EHDAA2:0002023 xref: EHDAA:2969 xref: EMAPA:17523 xref: TAO:0001077 xref: ZFA:0001077 is_a: UBERON:0001048 ! primordium is_a: UBERON:0003351 ! pharyngeal epithelium relationship: BFO:0000050 UBERON:0002405 {source="ZFA"} ! part of immune system relationship: BFO:0000050 UBERON:0003295 {source="EHDAA2"} ! part of pharyngeal gland relationship: RO:0002254 UBERON:0005428 ! has developmental contribution from vagal neural crest property_value: IAO:0000116 "we follow Kardong table 13.1 in having some developmental contribution of pouch 4 in mammals, but this isn't reflected in EHDAA2. Consider adding distinct term for mesenchyme (see EHDAA2), to indicate NC constribution." xsd:string {source="ISBN:0781714125"} [Term] id: UBERON:0005563 name: trigeminal neural crest def: "Cranial neural crest which gives rise to the trigeminal ganglion." [ZFA:0000080] subset: efo_slim subset: vertebrate_core xref: EFO:0003484 xref: EHDAA2:0002083 xref: EHDAA:667 xref: EMAPA:16170 xref: TAO:0000080 xref: VHOG:0000269 xref: ZFA:0000080 is_a: UBERON:0003099 {source="ZFA"} ! cranial neural crest is_a: UBERON:0005253 ! head mesenchyme is_a: UBERON:0007530 {source="EHDAA2"} ! migrating mesenchyme population relationship: BFO:0000050 UBERON:0007213 {source="EHDAA2"} ! part of mesenchyme derived from head neural crest property_value: IAO:0000116 "todo - compare ZFA and EHDAA2 representation" xsd:string property_value: skos:prefLabel "trigeminal neural crest" xsd:string [Term] id: UBERON:0005564 name: gonad primordium def: "Portion of tissue that gives rise to the immature gonad." [ZFA:0001262] subset: efo_slim subset: grouping_class subset: vertebrate_core synonym: "future gonad" EXACT [http://orcid.org/0000-0002-6601-2165] synonym: "gonadal primordium" EXACT [ZFA:0001262] synonym: "immature gonad" RELATED [http://orcid.org/0000-0002-6601-2165] synonym: "primitive gonad" EXACT [http://orcid.org/0000-0002-6601-2165] synonym: "undifferentiated gonad" EXACT [ZFA:0001262] xref: EFO:0003651 xref: EHDAA:5927 xref: EMAPA:17204 xref: RETIRED_EHDAA2:0002148 xref: TAO:0001262 xref: WBbt:0008366 xref: ZFA:0001262 is_a: UBERON:0001048 {source="Obol"} ! primordium relationship: BFO:0000050 UBERON:0000990 {source="ZFA"} ! part of reproductive system relationship: RO:0002387 UBERON:0000991 ! has potential to develop into gonad property_value: skos:prefLabel "gonad primordium" xsd:string [Term] id: UBERON:0005565 name: facio-acoustic neural crest def: "Cranial neural crest that gives rise to the facio-acoustic ganglion." [ZFA:0000762] subset: vertebrate_core synonym: "facio acoustic neural crest" EXACT [ZFA:0000762] xref: EHDAA2:0000492 xref: EHDAA:658 xref: EMAPA:16312 xref: TAO:0000762 xref: VHOG:0000268 xref: ZFA:0000762 is_a: UBERON:0003099 ! cranial neural crest is_a: UBERON:0007213 ! mesenchyme derived from head neural crest is_a: UBERON:0007530 {source="EHDAA2"} ! migrating mesenchyme population is_a: UBERON:0014387 ! mesenchyme derived from neural crest relationship: RO:0002202 UBERON:0003849 {source="EHDAA2"} ! develops from mesencephalic neural crest property_value: skos:prefLabel "facio-acoustic neural crest" xsd:string [Term] id: UBERON:0005567 name: rhombomere 1 lateral wall def: "A rhombomere lateral wall that is part of a rhombomere 1." [OBOL:automatic] subset: vertebrate_core synonym: "lateral wall rhombomere 1" EXACT [ZFA:0000781] xref: EHDAA2:0001641 xref: EMAPA:16482 xref: TAO:0000781 xref: ZFA:0000781 is_a: UBERON:0005501 ! rhombomere lateral wall intersection_of: UBERON:0005501 ! rhombomere lateral wall intersection_of: BFO:0000050 UBERON:0005499 ! part of rhombomere 1 relationship: BFO:0000050 UBERON:0005499 ! part of rhombomere 1 property_value: skos:prefLabel "rhombomere 1 lateral wall" xsd:string [Term] id: UBERON:0005568 name: rhombomere 1 roof plate def: "A rhombomere roof plate that is part of a rhombomere 1." [OBOL:automatic] subset: vertebrate_core synonym: "roof plate rhombomere 1" EXACT [ZFA:0001033] xref: DMBA:16916 xref: EHDAA2:0001645 xref: EMAPA:16483 xref: TAO:0001033 xref: ZFA:0001033 is_a: UBERON:0005502 ! rhombomere roof plate intersection_of: UBERON:0005502 ! rhombomere roof plate intersection_of: BFO:0000050 UBERON:0005499 ! part of rhombomere 1 relationship: BFO:0000050 UBERON:0005499 ! part of rhombomere 1 property_value: skos:prefLabel "rhombomere 1 roof plate" xsd:string [Term] id: UBERON:0005594 name: head somite def: "Somite located in the head region, caudal to the otic vesicle." [PMID:11830559] synonym: "cranial somite" RELATED [XAO:0000313] synonym: "occipital somite" EXACT [PMID:11830559, XAO:0000313] xref: EHDAA2:0003437 xref: EMAPA:16172 xref: XAO:0000313 is_a: UBERON:0002050 ! embryonic structure is_a: UBERON:0002329 ! somite is_a: UBERON:0005291 ! embryonic tissue intersection_of: UBERON:0002329 ! somite intersection_of: RO:0002202 UBERON:0009617 ! develops from head paraxial mesoderm relationship: BFO:0000050 UBERON:0009617 {source="EHDAA2"} ! part of head paraxial mesoderm relationship: RO:0002202 UBERON:0009617 {source="EHDAA2"} ! develops from head paraxial mesoderm property_value: skos:prefLabel "head somite" xsd:string [Term] id: UBERON:0005597 name: lung primordium def: "A pair of lateral diverticula just over the liver rudiment representing the primordia of the lungs, formed by the floor of the foregut just anterior to the liver diverticulum." [XAO:0001002] subset: efo_slim synonym: "lateral diverticula" RELATED [XAO:0001002] synonym: "lung diverticulum" RELATED [AAO:3010717] synonym: "lung endoderm" RELATED [EFO:0002578] xref: AAO:0011059 xref: EFO:0002578 xref: EMAPA:36007 xref: XAO:0001002 is_a: BFO:0000002 is_a: UBERON:0001048 {source="XAO"} ! primordium relationship: BFO:0000050 UBERON:0008947 ! part of respiratory primordium relationship: RO:0002202 UBERON:0001041 {source="XAO"} ! develops from foregut relationship: RO:0002387 UBERON:0000170 ! has potential to develop into pair of lungs property_value: skos:prefLabel "lung primordium" xsd:string [Term] id: UBERON:0005598 name: trunk somite def: "A somite that is part of a trunk." [OBOL:automatic] xref: AAO:0010385 xref: EHDAA2:0003438 xref: EMAPA:16184 xref: XAO:0000314 is_a: UBERON:0002329 ! somite intersection_of: UBERON:0002329 ! somite intersection_of: BFO:0000050 UBERON:0002100 ! part of trunk relationship: BFO:0000050 UBERON:0002100 ! part of trunk property_value: skos:prefLabel "trunk somite" xsd:string [Term] id: UBERON:0005604 name: extrahepatic part of hepatic duct synonym: "extrahepatic part of the hepatic duct" EXACT [VHOG:0000215] synonym: "hepatic duct extrahepatic part" EXACT [MA:0001636] xref: EMAPA:16844 xref: MA:0001636 xref: VHOG:0000215 is_a: UBERON:0002394 ! bile duct relationship: BFO:0000050 UBERON:0003703 {source="MA"} ! part of extrahepatic bile duct relationship: BFO:0000050 UBERON:0005171 {source="MA"} ! part of hepatic duct property_value: skos:prefLabel "extrahepatic part of hepatic duct" xsd:string [Term] id: UBERON:0005606 name: hyaloid cavity xref: EHDAA2:0000789 xref: EHDAA:4733 xref: EMAPA:17302 xref: FMA:312291 xref: MA:0000272 xref: VHOG:0001477 is_a: UBERON:0002553 ! anatomical cavity is_a: UBERON:0012467 ! enclosed anatomical space relationship: BFO:0000050 UBERON:0002203 ! part of vasculature of eye [Term] id: UBERON:0005609 name: iliac artery def: "Any of the arteries that arise from a bifurcation of the aorta supplying the pelvic or abdomen. Examples: Common iliac artery, External iliac artery, Internal iliac artery." [https://orcid.org/0000-0002-6601-2165, Wikipedia:Iliac_artery] subset: grouping_class xref: BTO:0004665 xref: EHDAA:2551 xref: EMAPA:17309 xref: galen:IliacArtery xref: MA:0001971 xref: MESH:D007083 xref: NCIT:C12733 xref: RETIRED_EHDAA2:0000807 xref: SCTID:244330006 xref: UMLS:C0020887 {source="ncithesaurus:Iliac_Artery"} xref: Wikipedia:Iliac_artery xref: XAO:0000361 is_a: UBERON:0004573 ! systemic artery relationship: BFO:0000050 UBERON:0010709 ! part of pelvic complex relationship: RO:0020101 UBERON:0002355 ! vessel supplies blood to pelvic region of trunk [Term] id: UBERON:0005610 name: iliac vein def: "Any of the three veins including the common, external and internal iliac veins." [ncithesaurus:Iliac_Vein] synonym: "pelvic vein" RELATED [] xref: EHDAA2:0000811 xref: EMAPA:37151 {source="MA:th"} xref: MA:0002142 xref: MESH:D007084 xref: NCIT:C12734 xref: SCTID:281481002 xref: UMLS:C0020888 {source="ncithesaurus:Iliac_Vein"} is_a: UBERON:0001638 ! vein relationship: RO:0020102 UBERON:0010708 ! vessel drains blood from pectoral complex [Term] id: UBERON:0005613 name: left dorsal aorta xref: EHDAA2:0000936 xref: EHDAA:404 xref: EMAPA:16205 xref: MA:0000478 xref: SCTID:361403005 xref: VHOG:0000484 is_a: UBERON:0000947 ! aorta is_a: UBERON:0003513 ! trunk blood vessel relationship: BFO:0000050 UBERON:0005805 ! part of dorsal aorta property_value: skos:prefLabel "left dorsal aorta" xsd:string [Term] id: UBERON:0005614 name: lens anterior epithelium def: "A layer of cuboidal epithelial cells bounded anteriorly by the capsule of the lens and posteriorly by the lens cortex." [http://orcid.org/0000-0002-6601-2165] synonym: "anterior epithelium of lens vesicle" RELATED [EMAPA:17304] synonym: "anterior surface of lens" RELATED [FMA:58889] synonym: "lens epithelium" BROAD [] synonym: "lens subcapsular epithelium" EXACT [http://www.lab.anhb.uwa.edu.au/mb140/corepages/eye/eye.htm] synonym: "subcapsular lens epithelium" EXACT [FMA:70612] xref: EHDAA2:0000984 xref: EHDAA:9059 xref: EMAPA:17304 xref: EMAPA:17839 xref: FMA:70612 xref: MA:0001302 xref: NCIT:C33641 xref: RETIRED_EHDAA2:0000976 xref: SCTID:362521008 xref: UMLS:C1182652 {source="ncithesaurus:Subcapsular_Epithelium_of_the_Lens"} xref: VHOG:0001425 is_a: UBERON:0001803 ! epithelium of lens is_a: UBERON:0010371 ! ecto-epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: BFO:0000050 UBERON:0000965 ! part of lens of camera-type eye intersection_of: RO:0002220 UBERON:0001804 ! adjacent to capsule of lens relationship: RO:0002220 UBERON:0000389 ! adjacent to lens cortex relationship: RO:0002220 UBERON:0001804 ! adjacent to capsule of lens property_value: skos:prefLabel "lens anterior epithelium" xsd:string [Term] id: UBERON:0005616 name: mesenteric artery def: "Arteries which arise from the abdominal aorta and distribute to most of the intestines." [MESH:A07.231.114.565, Wikipedia:Mesenteric_artery] xref: BTO:0000779 xref: EHDAA2:0001123 xref: EHDAA:4343 xref: EMAPA:17312 xref: MA:0002003 xref: MESH:D008638 xref: NCIT:C52975 xref: SCTID:281084003 xref: UMLS:C0025465 {source="ncithesaurus:Mesenteric_Artery"} xref: VHOG:0001117 xref: Wikipedia:Mesenteric_artery xref: XAO:0000370 is_a: UBERON:0012254 ! abdominal aorta artery intersection_of: UBERON:0001637 ! artery intersection_of: RO:0020101 UBERON:0000160 ! vessel supplies blood to intestine relationship: RO:0020101 UBERON:0000160 ! vessel supplies blood to intestine property_value: IAO:0000116 "includes posterior and anterior mesenteric arteries, which branch from the dorsal aorta (see Kardong), and superior and inferior mesenteric arteries" xsd:string property_value: skos:prefLabel "mesenteric artery" xsd:string [Term] id: UBERON:0005617 name: mesenteric vein def: "A vein that returns blood from the intestines." [MESH:A07.231.908.670.385, Wikipedia:Mesenteric_vein] synonym: "intestinal vein" RELATED [http://orcid.org/0000-0002-6601-2165] xref: BTO:0002781 xref: EHDAA:4442 xref: EMAPA:17348 xref: MA:0002177 xref: MESH:D008642 xref: NCIT:C53055 xref: RETIRED_EHDAA2:0001125 xref: SCTID:304045008 xref: UMLS:C0025473 {source="ncithesaurus:Mesenteric_Vein"} xref: Wikipedia:Mesenteric_vein is_a: UBERON:0001638 ! vein intersection_of: UBERON:0001638 ! vein intersection_of: RO:0020102 UBERON:0000160 ! vessel drains blood from intestine relationship: RO:0020102 UBERON:0000160 ! vessel drains blood from intestine property_value: skos:prefLabel "mesenteric vein" xsd:string [Term] id: UBERON:0005622 name: right dorsal aorta xref: EHDAA2:0001720 xref: EHDAA:406 xref: EMAPA:16206 xref: MA:0000479 xref: SCTID:361404004 xref: VHOG:0000485 is_a: UBERON:0000947 ! aorta is_a: UBERON:0003513 ! trunk blood vessel relationship: BFO:0000050 UBERON:0005805 ! part of dorsal aorta property_value: skos:prefLabel "right dorsal aorta" xsd:string [Term] id: UBERON:0005624 name: suprarenal artery def: "Artery that supplies blood to the adrenal glands." [Wikipedia:Adrenal_artery] subset: grouping_class synonym: "adrenal artery" RELATED [MA:0001914, Wikipedia:Adrenal_artery] xref: EHDAA2:0001965 xref: EHDAA:8596 xref: EMAPA:37124 {source="MA:th"} xref: MA:0001914 xref: NCIT:C33708 xref: ncithesaurus:Adrenal_Artery xref: SCTID:181342004 xref: Wikipedia:Adrenal_artery is_a: UBERON:0001637 ! artery intersection_of: UBERON:0001637 ! artery intersection_of: RO:0020101 UBERON:0002369 ! vessel supplies blood to adrenal gland relationship: RO:0020101 UBERON:0002369 ! vessel supplies blood to adrenal gland [Term] id: UBERON:0005625 name: tubotympanic recess lumen def: "The cavity formed by the tubotympanic recess epithelium." [https://orcid.org/0000-0002-6601-2165] synonym: "cavity of tubotympanic recess" EXACT [] synonym: "tubotympanic recess" RELATED [EHDAA2:0002095] synonym: "tubotympanic recess cavity" EXACT [] synonym: "tubotympanic recess space" EXACT [] xref: EHDAA2:0002095 is_a: BFO:0000002 is_a: UBERON:0002553 ! anatomical cavity is_a: UBERON:0007473 ! lumen of epithelial sac intersection_of: UBERON:0002553 ! anatomical cavity intersection_of: RO:0002572 UBERON:0010020 ! luminal space of tubotympanic recess epithelium relationship: RO:0002202 UBERON:0007122 {source="ISBN:0073040584"} ! develops from pharyngeal pouch 1 relationship: RO:0002572 UBERON:0010020 ! luminal space of tubotympanic recess epithelium [Term] id: UBERON:0005626 name: ventral mesogastrium def: "Portion of ventral mesentery closest to the stomach." [Wikipedia:Ventral_mesentery] comment: "The primitive gut is enveloped by a mesentery that has a dorsal and a ventral aspect. The ventral mesentery degenerates during development with the exception of the foregut ventral mesentery, which develops into specialized structures (see foregut embryology)." [http://sprojects.mmi.mcgill.ca/embryology/gi/pgm.htm]. todo - check subset: vertebrate_core synonym: "foregut ventral mesentery" RELATED [Wikipedia:Ventral_mesentery] xref: EHDAA2:0002176 xref: EHDAA:3005 xref: EMAPA:17026 xref: MA:0001621 xref: NCIT:C34327 xref: TAO:0005133 xref: UMLS:C1519967 {source="ncithesaurus:Ventral_Mesogastrium"} xref: VHOG:0000351 xref: ZFA:0005133 is_a: UBERON:0003281 ! mesentery of stomach relationship: BFO:0000050 UBERON:0009668 {source="EHDAA2"} ! part of ventral mesentery property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/c/cf/Gray984.png" xsd:anyURI [Term] id: UBERON:0005629 name: vascular plexus def: "A vascular network formed by frequent anastomoses between the blood vessels (arteries or veins) of a part." [http://www.medilexicon.com/medicaldictionary.php?t=70052] synonym: "plexus vasculosus" EXACT OMO:0003011 [] xref: AEO:0000219 xref: EHDAA2:0004112 xref: EMAPA:35904 xref: FMA:5900 xref: XAO:0004143 is_a: BFO:0000002 is_a: UBERON:0002049 ! vasculature relationship: BFO:0000051 UBERON:0001981 ! has part blood vessel property_value: skos:prefLabel "vascular plexus" xsd:string [Term] id: UBERON:0005631 name: extraembryonic membrane def: "Intrinsic membrane that arises from embryonic germ layers and grow to surround the developing embryo." [ISBN:0073040584] xref: EHDAA2:0004714 xref: FMA:305915 xref: SCTID:362840007 is_a: UBERON:0000158 ! membranous layer relationship: BFO:0000050 UBERON:0016887 ! part of entire extraembryonic component property_value: seeAlso "https://github.com/obophenotype/uberon/wiki/Modeling-extraembryonic-membranes" xsd:anyURI property_value: skos:prefLabel "extraembryonic membrane" xsd:string [Term] id: UBERON:0005636 name: caecum epithelium def: "An epithelium that is part of a caecum." [OBOL:automatic] xref: EHDAA2:0000209 is_a: UBERON:0000397 ! colonic epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: BFO:0000050 UBERON:0001153 ! part of caecum relationship: BFO:0000050 UBERON:0001153 ! part of caecum [Term] id: UBERON:0005637 name: pyloric region epithelium def: "An epithelium that is part of a pylorus." [OBOL:automatic] xref: EHDAA2:0001582 xref: EMAPA:17633 xref: RETIRED_EHDAA2:0001927 is_a: UBERON:0001276 ! epithelium of stomach intersection_of: UBERON:0000483 ! epithelium intersection_of: BFO:0000050 UBERON:0001166 ! part of pylorus relationship: BFO:0000050 UBERON:0001166 ! part of pylorus property_value: skos:prefLabel "pyloric region epithelium" xsd:string [Term] id: UBERON:0005638 name: anterior chamber epithelium def: "An epithelium that is part of a anterior chamber of eyeball." [OBOL:automatic] xref: EHDAA2:0000130 is_a: UBERON:0015808 ! eye epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: BFO:0000050 UBERON:0001766 ! part of anterior chamber of eyeball relationship: BFO:0000050 UBERON:0001766 ! part of anterior chamber of eyeball property_value: skos:prefLabel "anterior chamber epithelium" xsd:string [Term] id: UBERON:0005656 name: lens vesicle epithelium def: "An epithelium that is part of a lens vesicle." [OBOL:automatic] xref: EHDAA2:0000987 xref: EMAPA:17165 xref: VHOG:0000532 is_a: UBERON:0000483 ! epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: BFO:0000050 UBERON:0005426 ! part of lens vesicle relationship: BFO:0000050 UBERON:0005426 ! part of lens vesicle property_value: skos:prefLabel "lens vesicle epithelium" xsd:string [Term] id: UBERON:0005660 name: 2nd arch ectoderm def: "An ectoderm that is part of a pharyngeal arch 2." [OBOL:automatic] synonym: "2nd pharyngeal arch ectoderm" EXACT [VHOG:0001062] xref: EHDAA2:0000055 xref: EMAPA:16277 xref: EMAPA:16397 xref: EMAPA:16398 xref: RETIRED_EHDAA2:0000064 xref: VHOG:0001062 is_a: UBERON:0000924 ! ectoderm intersection_of: UBERON:0000924 ! ectoderm intersection_of: BFO:0000050 UBERON:0003066 ! part of pharyngeal arch 2 relationship: BFO:0000050 UBERON:0003066 ! part of pharyngeal arch 2 property_value: skos:prefLabel "2nd arch ectoderm" xsd:string [Term] id: UBERON:0005661 name: 3rd arch ectoderm def: "An ectoderm that is part of a pharyngeal arch 3." [OBOL:automatic] synonym: "3rd pharyngeal arch ectoderm" EXACT [VHOG:0000946] xref: EHDAA2:0000072 xref: EMAPA:16400 xref: EMAPA:16582 xref: EMAPA:16584 xref: RETIRED_EHDAA2:0000079 xref: VHOG:0000946 is_a: UBERON:0000924 ! ectoderm intersection_of: UBERON:0000924 ! ectoderm intersection_of: BFO:0000050 UBERON:0003114 ! part of pharyngeal arch 3 relationship: BFO:0000050 UBERON:0003114 ! part of pharyngeal arch 3 property_value: skos:prefLabel "3rd arch ectoderm" xsd:string [Term] id: UBERON:0005662 name: 4th arch ectoderm def: "An ectoderm that is part of a pharyngeal arch 4." [OBOL:automatic] synonym: "4th pharyngeal arch ectoderm" EXACT [VHOG:0001095] xref: EHDAA2:0004032 xref: EMAPA:16762 xref: EMAPA:16764 xref: EMAPA:16768 xref: RETIRED_EHDAA2:0000094 xref: VHOG:0001095 is_a: UBERON:0000924 ! ectoderm intersection_of: UBERON:0000924 ! ectoderm intersection_of: BFO:0000050 UBERON:0003115 ! part of pharyngeal arch 4 relationship: BFO:0000050 UBERON:0003115 ! part of pharyngeal arch 4 property_value: skos:prefLabel "4th arch ectoderm" xsd:string [Term] id: UBERON:0005664 name: 2nd arch endoderm def: "An endoderm that is part of a pharyngeal arch 2." [OBOL:automatic] synonym: "2nd pharyngeal arch endoderm" EXACT [VHOG:0001108] xref: EHDAA2:0000061 xref: EMAPA:16274 xref: EMAPA:16276 xref: EMAPA:16278 xref: RETIRED_EHDAA2:0000065 xref: VHOG:0001108 is_a: UBERON:0000925 ! endoderm intersection_of: UBERON:0000925 ! endoderm intersection_of: BFO:0000050 UBERON:0003066 ! part of pharyngeal arch 2 relationship: BFO:0000050 UBERON:0003066 ! part of pharyngeal arch 2 property_value: skos:prefLabel "2nd arch endoderm" xsd:string [Term] id: UBERON:0005665 name: 3rd arch endoderm def: "An endoderm that is part of a pharyngeal arch 3." [OBOL:automatic] synonym: "3rd pharyngeal arch endoderm" EXACT [VHOG:0001081] xref: EHDAA2:0000075 xref: EMAPA:16401 xref: EMAPA:16585 xref: EMAPA:16587 xref: RETIRED_EHDAA2:0000080 xref: VHOG:0001081 is_a: UBERON:0000925 ! endoderm intersection_of: UBERON:0000925 ! endoderm intersection_of: BFO:0000050 UBERON:0003114 ! part of pharyngeal arch 3 relationship: BFO:0000050 UBERON:0003114 ! part of pharyngeal arch 3 property_value: skos:prefLabel "3rd arch endoderm" xsd:string [Term] id: UBERON:0005666 name: 4th arch endoderm def: "An endoderm that is part of a pharyngeal arch 4." [OBOL:automatic] synonym: "4th pharyngeal arch endoderm" EXACT [VHOG:0001092] xref: EHDAA2:0004033 xref: EMAPA:16765 xref: EMAPA:16767 xref: EMAPA:16769 xref: RETIRED_EHDAA2:0000095 xref: VHOG:0001092 is_a: UBERON:0000925 ! endoderm intersection_of: UBERON:0000925 ! endoderm intersection_of: BFO:0000050 UBERON:0003115 ! part of pharyngeal arch 4 relationship: BFO:0000050 UBERON:0003115 ! part of pharyngeal arch 4 property_value: skos:prefLabel "4th arch endoderm" xsd:string [Term] id: UBERON:0005667 name: connecting stalk mesoderm xref: EHDAA2:0000314 is_a: UBERON:0003422 ! mesenchyme of umbilical cord is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0007524 {source="EHDAA2"} ! dense mesenchyme tissue relationship: RO:0002202 UBERON:0005728 {source="EHDAA2"} ! develops from extraembryonic mesoderm [Term] id: UBERON:0005669 name: peritoneal cavity mesothelium def: "A mesothelium that is part of a peritoneal cavity." [OBOL:automatic] synonym: "mesothelium of peritoneal component" EXACT [EMAPA:16139] synonym: "mesothelium of peritoneum" EXACT [FMA:18147] synonym: "peritoneal mesothelium" EXACT [BTO:0003156, EMAPA:16139] synonym: "peritoneum" BROAD INCONSISTENT [EMAPA:16139] synonym: "peritoneum mesothelium" EXACT [FMA:18147] xref: BTO:0003156 xref: EHDAA2:0001447 xref: EMAPA:16139 xref: FMA:18147 xref: SCTID:34073007 is_a: UBERON:0001136 ! mesothelium intersection_of: UBERON:0001136 ! mesothelium intersection_of: RO:0001025 UBERON:0001179 ! located in peritoneal cavity relationship: RO:0001025 UBERON:0001179 ! located in peritoneal cavity property_value: skos:prefLabel "peritoneal cavity mesothelium" xsd:string [Term] id: UBERON:0005672 name: right lung endothelium def: "An endothelium that is part of a right lung." [OBOL:automatic] xref: EHDAA2:0001755 is_a: UBERON:0001986 ! endothelium is_a: UBERON:0003364 ! epithelium of right lung intersection_of: UBERON:0001986 ! endothelium intersection_of: BFO:0000050 UBERON:0002167 ! part of right lung property_value: skos:prefLabel "right lung endothelium" xsd:string [Term] id: UBERON:0005673 name: left lung endothelium def: "An endothelium that is part of a left lung." [OBOL:automatic] xref: EHDAA2:0000961 is_a: UBERON:0001986 ! endothelium is_a: UBERON:0003365 ! epithelium of left lung intersection_of: UBERON:0001986 ! endothelium intersection_of: BFO:0000050 UBERON:0002168 ! part of left lung property_value: skos:prefLabel "left lung endothelium" xsd:string [Term] id: UBERON:0005677 name: caecum mesentery def: "A mesentery that is part of a caecum." [OBOL:automatic] xref: RETIRED_EHDAA2:0000210 is_a: UBERON:0003396 ! mesentery of colon intersection_of: UBERON:0002095 ! mesentery intersection_of: BFO:0000050 UBERON:0001153 ! part of caecum relationship: BFO:0000050 UBERON:0001153 ! part of caecum [Term] id: UBERON:0005687 name: orbitosphenoid cartilage element def: "An orbitosphenoid endochondral element that is composed primarily of cartilage tissue." [OBOL:automatic] synonym: "sphenoid lesser wing cartilage element" RELATED [EHDAA2:0001329] xref: EHDAA2:0001329 xref: EHDAA:9554 is_a: UBERON:0003932 ! cartilage element of chondrocranium is_a: UBERON:0005863 {source="EHDAA2"} ! cartilaginous condensation is_a: UBERON:0006904 ! head mesenchyme from mesoderm is_a: UBERON:0009891 ! facial mesenchyme is_a: UBERON:0015059 ! orbitosphenoid endochondral element intersection_of: UBERON:0015059 ! orbitosphenoid endochondral element intersection_of: RO:0002473 UBERON:0002418 ! composed primarily of cartilage tissue relationship: BFO:0000050 UBERON:0009193 {source="EHDAA2"} ! part of sphenoid cartilage element relationship: RO:0002202 UBERON:0010728 {source="EHDAA2"} ! develops from sphenoid lesser wing pre-cartilage condensation property_value: skos:prefLabel "orbitosphenoid cartilage element" xsd:string [Term] id: UBERON:0005688 name: lens vesicle cavity def: "An anatomical cavity that is part of a lens vesicle." [OBOL:automatic] synonym: "cavity of lens" BROAD [] synonym: "cavity of lens vesicle" EXACT [EMAPA:17164] synonym: "lens cavity" BROAD [EHDAA2:0000986] xref: EHDAA2:0000986 xref: EMAPA:17164 xref: VHOG:0000531 is_a: UBERON:0000464 ! anatomical space intersection_of: UBERON:0000464 ! anatomical space intersection_of: RO:0002572 UBERON:0005426 ! luminal space of lens vesicle relationship: RO:0002572 UBERON:0005426 ! luminal space of lens vesicle property_value: skos:prefLabel "lens vesicle cavity" xsd:string [Term] id: UBERON:0005689 name: 2nd arch mesenchyme def: "Mesenchyme that is part of a pharyngeal arch 2." [OBOL:automatic] synonym: "2nd branchial arch mesenchyme" RELATED [] synonym: "2nd pharyngeal arch mesenchyme" EXACT [VHOG:0001102] synonym: "pharyngeal arch 2 mesenchyme" RELATED [] xref: EHDAA2:0000066 xref: EHDAA:625 xref: EMAPA:16279 xref: FMA:295698 xref: VHOG:0001102 is_a: UBERON:0009494 ! pharyngeal arch mesenchymal region intersection_of: UBERON:0003104 ! mesenchyme intersection_of: BFO:0000050 UBERON:0003066 ! part of pharyngeal arch 2 relationship: BFO:0000050 UBERON:0003066 ! part of pharyngeal arch 2 property_value: skos:prefLabel "2nd arch mesenchyme" xsd:string [Term] id: UBERON:0005690 name: 3rd arch mesenchyme def: "Mesenchyme that is part of a pharyngeal arch 3." [OBOL:automatic] synonym: "3rd branchial arch mesenchyme" RELATED [] synonym: "3rd pharyngeal arch mesenchyme" EXACT [VHOG:0001083] synonym: "pharyngeal arch 3 mesenchyme" RELATED [] xref: EHDAA2:0000081 xref: EHDAA:1094 xref: EMAPA:16402 xref: FMA:295700 xref: VHOG:0001083 is_a: UBERON:0009494 ! pharyngeal arch mesenchymal region intersection_of: UBERON:0003104 ! mesenchyme intersection_of: BFO:0000050 UBERON:0003114 ! part of pharyngeal arch 3 relationship: BFO:0000050 UBERON:0003114 ! part of pharyngeal arch 3 property_value: skos:prefLabel "3rd arch mesenchyme" xsd:string [Term] id: UBERON:0005691 name: 4th arch mesenchyme def: "Mesenchyme that is part of a pharyngeal arch 4." [OBOL:automatic] synonym: "4th branchial arch mesenchyme" RELATED [] synonym: "4th pharyngeal arch mesenchyme" EXACT [VHOG:0001052] synonym: "pharyngeal arch 4 mesenchyme" RELATED [] xref: EHDAA2:0000096 xref: EHDAA:1677 xref: EMAPA:16770 xref: FMA:295702 xref: VHOG:0001052 is_a: UBERON:0009494 ! pharyngeal arch mesenchymal region intersection_of: UBERON:0003104 ! mesenchyme intersection_of: BFO:0000050 UBERON:0003115 ! part of pharyngeal arch 4 relationship: BFO:0000050 UBERON:0003115 ! part of pharyngeal arch 4 property_value: skos:prefLabel "4th arch mesenchyme" xsd:string [Term] id: UBERON:0005702 name: optic eminence mesenchyme def: "Mesenchyme that is part of a optic eminence." [OBOL:automatic] xref: EHDAA:942 xref: EMAPA:16324 xref: RETIRED_EHDAA2:0001310 xref: VHOG:0001073 is_a: UBERON:0003104 ! mesenchyme is_a: UBERON:0005291 ! embryonic tissue intersection_of: UBERON:0003104 ! mesenchyme intersection_of: BFO:0000050 UBERON:0004348 ! part of optic eminence relationship: BFO:0000050 UBERON:0004348 ! part of optic eminence property_value: skos:prefLabel "optic eminence mesenchyme" xsd:string [Term] id: UBERON:0005711 name: foregut duodenum mesentery def: "A mesentery of duodenum that is part of a foregut." [OBOL:automatic] xref: EHDAA2:0000564 is_a: UBERON:0003397 ! mesentery of duodenum is_a: UBERON:0004121 ! ectoderm-derived structure intersection_of: UBERON:0003397 ! mesentery of duodenum intersection_of: BFO:0000050 UBERON:0001041 ! part of foregut relationship: BFO:0000050 UBERON:0001041 ! part of foregut relationship: RO:0002202 UBERON:0011642 ! develops from oral epithelium from ectoderm [Term] id: UBERON:0005712 name: midgut duodenum mesentery def: "A mesentery of duodenum that is part of a midgut." [OBOL:automatic] xref: EHDAA2:0001193 is_a: UBERON:0003284 ! mesentery of midgut is_a: UBERON:0003397 ! mesentery of duodenum is_a: UBERON:0004121 ! ectoderm-derived structure intersection_of: UBERON:0003397 ! mesentery of duodenum intersection_of: BFO:0000050 UBERON:0001045 ! part of midgut relationship: RO:0002202 UBERON:0011642 ! develops from oral epithelium from ectoderm [Term] id: UBERON:0005719 name: footplate apical ectodermal ridge def: "An apical ectodermal ridge that is part of a footplate." [OBOL:automatic] xref: EHDAA2:0000547 xref: EMAPA:17251 is_a: UBERON:0004356 ! apical ectodermal ridge intersection_of: UBERON:0004356 ! apical ectodermal ridge intersection_of: BFO:0000050 UBERON:0006871 ! part of embryonic footplate relationship: BFO:0000050 UBERON:0003373 {is_inferred="true", source="https://github.com/obophenotype/uberon/wiki/Inferring-part-of-relationships"} ! part of ectoderm of footplate [Term] id: UBERON:0005720 name: hindbrain venous system def: "A venous system that is part of a hindbrain." [OBOL:automatic] synonym: "rhombencephalon venous system" RELATED [VHOG:0001322] xref: EHDAA2:0000776 xref: EMAPA:18632 xref: VHOG:0001322 is_a: UBERON:0004582 ! venous system intersection_of: UBERON:0004582 ! venous system intersection_of: BFO:0000050 UBERON:0002028 ! part of hindbrain relationship: BFO:0000050 UBERON:0002028 ! part of hindbrain property_value: skos:prefLabel "hindbrain venous system" xsd:string [Term] id: UBERON:0005721 name: pronephric mesoderm def: "A mesoderm that has the potential to develop into a pronephros." [OBOL:automatic] comment: the intermediate mesoderm of the chick embryo acquires its ability to form kidneys through its interactions with the paraxial mesoderm [ISBN:9780878932504 "Developmental Biology", PMID:10720431 "Signals from trunk paraxial mesoderm induce pronephros formation in chick intermediate mesoderm"]. These interactions induce the expression of TFs including Lim1, Pax2 and Pax6 that cause the intermediate mesoderm to form the kidney subset: efo_slim synonym: "pronephric anlage" RELATED [XAO:0000264] synonym: "pronephric bulge" RELATED [XAO:0000264] synonym: "pronephric mesenchyme" RELATED [XAO:0000264] synonym: "pronephric primordium" RELATED [XAO:0000264] xref: AAO:0011090 xref: EFO:0003479 xref: TAO:0000067 xref: VHOG:0001239 xref: XAO:0000264 xref: ZFA:0000067 is_a: UBERON:0000926 ! mesoderm is_a: UBERON:0006598 ! presumptive structure intersection_of: UBERON:0000926 ! mesoderm intersection_of: RO:0002387 UBERON:0002120 ! has potential to develop into pronephros relationship: BFO:0000050 UBERON:0003064 {source="ZFA"} ! part of intermediate mesoderm relationship: RO:0002387 UBERON:0002120 ! has potential to develop into pronephros relationship: RO:0002495 UBERON:0007297 {source="Bgee:AN"} ! immediate transformation of presumptive pronephric mesoderm [Term] id: UBERON:0005723 name: floor plate spinal cord region def: "A multi-tissue structure that is part of a spinal cord and is part of a floor plate." [OBOL:automatic] subset: vertebrate_core synonym: "floor plate spinal cord" EXACT [VHOG:0000787] synonym: "floorplate spinal cord" EXACT [ZFA:0000890] synonym: "spinal cord floor" RELATED [VHOG:0000787] xref: EMAPA:17578 xref: TAO:0000890 xref: VHOG:0000787 xref: XAO:0000306 xref: ZFA:0000890 is_a: BFO:0000002 is_a: UBERON:0001948 ! regional part of spinal cord is_a: UBERON:0003306 ! floor plate of neural tube intersection_of: UBERON:0000481 ! multi-tissue structure intersection_of: BFO:0000050 UBERON:0002240 ! part of spinal cord intersection_of: BFO:0000050 UBERON:0003079 ! part of floor plate relationship: RO:0002202 UBERON:0003306 ! develops from floor plate of neural tube property_value: skos:prefLabel "floor plate spinal cord region" xsd:string [Term] id: UBERON:0005724 name: roof plate spinal cord region def: "A tissue that is part of a spinal cord and is part of a roof plate." [OBOL:automatic] synonym: "roof plate spinal cord" EXACT [VHOG:0000777] synonym: "roofplate spinal cord" RELATED [VHOG:0000777] synonym: "spinal cord roof" RELATED [VHOG:0000777] xref: EMAPA:17586 xref: TAO:0001177 xref: VHOG:0000777 xref: XAO:0000022 xref: ZFA:0001177 is_a: UBERON:0005291 ! embryonic tissue intersection_of: UBERON:0000479 ! tissue intersection_of: BFO:0000050 UBERON:0002240 ! part of spinal cord intersection_of: BFO:0000050 UBERON:0003054 ! part of roof plate relationship: BFO:0000050 UBERON:0002240 ! part of spinal cord relationship: BFO:0000050 UBERON:0003054 ! part of roof plate property_value: skos:prefLabel "roof plate spinal cord region" xsd:string [Term] id: UBERON:0005725 name: olfactory system def: "A sensory system that is capable of olfaction (the sensory perception of smell)." [http://orcid.org/0000-0002-6601-2165] subset: efo_slim subset: pheno_slim subset: vertebrate_core xref: AAO:0000334 xref: AAO:0000978 xref: BILA:0000144 xref: EFO:0001973 xref: EMAPA:36004 xref: FMA:7190 xref: MA:0002445 xref: NCIT:C94501 xref: NLXANAT:090806 xref: SCTID:362290002 xref: TAO:0001149 xref: UMLS:C0228065 {source="ncithesaurus:Olfactory_System"} xref: Wikipedia:Olfactory_system xref: XAO:0003196 xref: ZFA:0001149 is_a: UBERON:0005726 ! chemosensory system intersection_of: UBERON:0001032 ! sensory system intersection_of: RO:0002215 GO:0007608 ! capable of sensory perception of smell relationship: RO:0002215 GO:0007608 ! capable of sensory perception of smell relationship: RO:0002492 UBERON:0000066 ! existence ends during fully formed stage property_value: IAO:0000116 "consider splitting into main and accessory. See also: vomeronasal organ" xsd:string property_value: IAO:0000116 "we make the relationship to nervous system 'overlaps', as the olfactory system includes e.g. apertures in the cranium that are not part of the nervous system" xsd:string property_value: skos:prefLabel "olfactory system" xsd:string [Term] id: UBERON:0005726 name: chemosensory system subset: functional_classification xref: BILA:0000139 is_a: UBERON:0001032 ! sensory system intersection_of: UBERON:0001032 ! sensory system intersection_of: RO:0002215 GO:0007606 ! capable of sensory perception of chemical stimulus relationship: RO:0002215 GO:0007606 ! capable of sensory perception of chemical stimulus property_value: skos:prefLabel "chemosensory system" xsd:string [Term] id: UBERON:0005728 name: extraembryonic mesoderm synonym: "extra-embryonic mesoderm" EXACT [] synonym: "extraembryonic mesenchyme" EXACT [] xref: EHDAA2:0000474 xref: EMAPA:31862 xref: EMAPA:31863 xref: FMA:296719 xref: VHOG:0000616 is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0005292 ! extraembryonic tissue is_a: UBERON:0007524 {source="EHDAA2"} ! dense mesenchyme tissue relationship: RO:0002202 UBERON:0003081 ! develops from lateral plate mesoderm relationship: RO:0002202 UBERON:0008780 {source="EHDAA2"} ! develops from inner cell mass derived epiblast property_value: skos:prefLabel "extraembryonic mesoderm" xsd:string [Term] id: UBERON:0005729 name: pectoral appendage field def: "A limb/fin field that has the potential to develop into a pectoral appendage bud mesenchyme." [OBOL:automatic] synonym: "pectoral appendage field of lateral plate mesoderm" EXACT [] synonym: "pectoral fin field" NARROW SENSU [ZFA:0001453] xref: TAO:0001453 xref: ZFA:0001453 is_a: UBERON:0005732 ! paired limb/fin field is_a: UBERON:0006598 ! presumptive structure intersection_of: UBERON:0005732 ! paired limb/fin field intersection_of: RO:0002387 UBERON:0003413 ! has potential to develop into pectoral appendage bud mesenchyme relationship: RO:0002387 UBERON:0003413 ! has potential to develop into pectoral appendage bud mesenchyme property_value: skos:prefLabel "pectoral appendage field" xsd:string [Term] id: UBERON:0005730 name: pelvic appendage field def: "A limb/fin field that has the potential to develop into a pelvic appendage bud mesenchyme." [OBOL:automatic] synonym: "pelvic appendage field of lateral plate mesoderm" EXACT [] synonym: "pelvic fin field" NARROW SENSU [ZFA:0001454] xref: TAO:0001454 xref: ZFA:0001454 is_a: UBERON:0005732 ! paired limb/fin field is_a: UBERON:0006598 ! presumptive structure intersection_of: UBERON:0005732 ! paired limb/fin field intersection_of: RO:0002387 UBERON:0003412 ! has potential to develop into pelvic appendage bud mesenchyme relationship: RO:0002387 UBERON:0003412 ! has potential to develop into pelvic appendage bud mesenchyme [Term] id: UBERON:0005732 name: paired limb/fin field def: "A ring of cells capable of forming a limb or paired fin[Gilbert,modified]." [ISBN:9780878932504] subset: homology_grouping synonym: "limb/fin field of lateral plate mesoderm" EXACT [] synonym: "paired limb/fin field" EXACT [] is_a: UBERON:0002050 ! embryonic structure is_a: UBERON:0005291 ! embryonic tissue is_a: UBERON:0007688 ! anlage intersection_of: UBERON:0007688 ! anlage intersection_of: RO:0002385 UBERON:0004357 ! has potential to developmentally contribute to paired limb/fin bud relationship: BFO:0000050 UBERON:0003081 {source="ISBN:9780878932504", source="ZFA-inferred"} ! part of lateral plate mesoderm relationship: RO:0002385 UBERON:0004357 ! has potential to developmentally contribute to paired limb/fin bud property_value: IAO:0000116 "we represent the field as being a part of the LPM (consistent with ZFA, Gilbert). As a consequence, the relationship between limb bud (with is ectoderm+mesenchyme) stands in a weaker has_developmental_contribution_from relation to the field - TODO implement this." xsd:string property_value: skos:prefLabel "paired limb/fin field" xsd:string [Term] id: UBERON:0005733 name: limb field def: "A ring of cells capable of forming a limb." [ISBN:9780878932504] comment: the central portion of the limb field gives rise to the limb proper. mesenchyme cells proliferate from from the somatic layer of limb field lateral plate mesoderm (limb skeletal precursors) and from the somites (limb muscle precursors) . these mesenchymal cells accumulate under the ectedermal tissue to make a limb bud. // The lateral plate mesoderm in the limb field is also special in that it will induce myoblasts to migrate out from the somites and enter the limb bud. No other region of the lateral plate mesoderm will do that (Hayashi and Ozawa 1995) synonym: "limb field of lateral plate mesoderm" EXACT [] is_a: UBERON:0005732 ! paired limb/fin field intersection_of: UBERON:0005732 ! paired limb/fin field intersection_of: RO:0002385 UBERON:0004347 ! has potential to developmentally contribute to limb bud relationship: RO:0002385 UBERON:0004347 ! has potential to developmentally contribute to limb bud [Term] id: UBERON:0005734 name: tunica adventitia of blood vessel def: "The outermost layer of a blood vessel, composed mainly of fibrous tissue." [ISBN:0073040584, Wikipedia:Tunica_externa_(vessels)] synonym: "adventitia externa" EXACT [Wikipedia:Tunica_externa_(vessels)] synonym: "external coat" RELATED [Wikipedia:Tunica_externa_(vessels)] synonym: "tunica adventitia" EXACT [Wikipedia:Tunica_externa_(vessels)] synonym: "tunica adventitia of vessel" EXACT [Wikipedia:Tunica_externa_(vessels)] synonym: "tunica adventitia vasorum" RELATED OMO:0003011 [Wikipedia:Tunica_externa_(vessels)] synonym: "tunica externa vasorum" RELATED OMO:0003011 [Wikipedia:Tunica_externa_(vessels)] xref: BTO:0002010 xref: EMAPA:36299 xref: NCIT:C33818 xref: SCTID:61066005 xref: UMLS:C0225342 {source="ncithesaurus:Tunica_Adventitia"} xref: Wikipedia:Tunica_externa_(vessels) is_a: UBERON:0004797 {source="cjm"} ! blood vessel layer is_a: UBERON:0005742 ! adventitia relationship: RO:0000086 PATO:0002462 ! has quality collagenous relationship: RO:0002473 UBERON:0011824 ! composed primarily of fibrous connective tissue property_value: foaf:depiction "https://upload.wikimedia.org/wikipedia/commons/3/32/Illu_artery.jpg" xsd:anyURI property_value: IAO:0000116 "TODO - note terminological problems. WP says tunica external layer of blood vessel. FMA says tunica externa = adventitia, and is FMA adventitia covers other kinds of vessels. Here we opt for a lengthier name that attempts to disambiguate. There is no precise FMA equivalent, as FMA has tunica externa of arteries, veins, genital ducts etc as siblings" xsd:string property_value: skos:prefLabel "tunica adventitia of blood vessel" xsd:string [Term] id: UBERON:0005740 name: tunica intima of artery def: "A tunica intima that is part of a artery." [OBOL:automatic] synonym: "arterial intima" EXACT [EV:0100028] synonym: "tunica interna (intima)(arteriae)" EXACT [FMA:14272] xref: EMAPA:36293 xref: EV:0100028 xref: FMA:14272 xref: galen:IntimaOfArtery xref: SCTID:40022005 is_a: UBERON:0002523 ! tunica intima is_a: UBERON:0004797 ! blood vessel layer intersection_of: UBERON:0002523 ! tunica intima intersection_of: BFO:0000050 UBERON:0001637 ! part of artery relationship: BFO:0000050 UBERON:0000415 ! part of artery wall property_value: skos:prefLabel "tunica intima of artery" xsd:string [Term] id: UBERON:0005742 name: adventitia def: "An outermost connective tissue covering of an organ, vessel, or other structure[WP]." [Wikipedia:Adventitia] subset: grouping_class subset: human_reference_atlas synonym: "tunica advetitia" NARROW [Wikipedia:Adventitia] synonym: "tunica externa" NARROW [FMA:45635] xref: BTO:0002010 xref: FMA:45635 xref: SCTID:30180000 xref: Wikipedia:Adventitia is_a: UBERON:0004923 ! organ component layer relationship: RO:0002473 UBERON:0002384 ! composed primarily of connective tissue property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/e/e8/Illu_esophageal_layers.jpg" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "adventitia" xsd:string [Term] id: UBERON:0005744 name: bone foramen def: "Anatomical space that is an opening in a bone, usually for passage of blood vessels or nerves." [TAO:curator] subset: vertebrate_core synonym: "foramen" BROAD [ZFA:0005386] xref: AAO:0010438 xref: TAO:0001736 xref: VHOG:0001760 xref: ZFA:0005386 is_a: UBERON:0004111 ! anatomical conduit intersection_of: UBERON:0004111 ! anatomical conduit intersection_of: BFO:0000050 UBERON:0001474 ! part of bone element relationship: BFO:0000050 UBERON:0001474 ! part of bone element property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/8/81/Gray193.png" xsd:anyURI property_value: skos:prefLabel "bone foramen" xsd:string [Term] id: UBERON:0005745 name: optic foramen def: "An opening in the skull through which cranial nerve II passes.[MP]." [https://github.com/obophenotype/uberon/issues/1213, ISBN:0-683-40008-8, MP:0010704, Wikipedia:Optic_canal] comment: In teleost fishes the opening is wider that in mammals. Due to the longer and deeper shape in mammals, this is usually called the optic canal; sometimes the term optic foramen may be used for the opening of the canal, but here we use this term to denote the entire space together with surrounding bone surface. subset: pheno_slim subset: vertebrate_core synonym: "canalis opticus" RELATED OMO:0003011 [Wikipedia:Optic_canal] synonym: "foramen opticum ossis sphenoidalis" RELATED OMO:0003011 [Wikipedia:Optic_canal] synonym: "optic canal" EXACT [Wikipedia:Optic_canal] synonym: "optic foramen" EXACT [Wikipedia:Optic_canal] synonym: "optic nerve (II) foramen" EXACT [ZFA:0005428, ZFIN:ZDB-PUB-961014-192] synonym: "optic nerve foramen" EXACT [TAO:0002025] xref: AAO:0000342 xref: EHDAA2:0001312 xref: EHDAA:10646 xref: EMAPA:18716 xref: FMA:54774 xref: SCTID:361732009 xref: TAO:0002025 xref: VHOG:0001408 xref: Wikipedia:Optic_canal xref: ZFA:0005428 is_a: UBERON:0013685 ! foramen of skull is_a: UBERON:0015212 ! lateral structure intersection_of: UBERON:0013685 ! foramen of skull intersection_of: RO:0002570 UBERON:0000941 ! conduit for cranial nerve II relationship: BFO:0000050 UBERON:0002478 ! part of orbitosphenoid relationship: BSPO:0000126 UBERON:0001677 {source="FMA-abduced-lr"} ! sphenoid bone relationship: RO:0002570 UBERON:0000941 ! conduit for cranial nerve II relationship: RO:0002570 UBERON:0001619 ! conduit for ophthalmic artery property_value: foaf:depiction "https://upload.wikimedia.org/wikipedia/commons/8/8e/Orbita_mensch.jpg" xsd:anyURI property_value: skos:prefLabel "optic foramen" xsd:string [Term] id: UBERON:0005749 name: glomerular tuft def: "The capillary loops of the kidney that normally function as a filtration unit[MP]." [http://www.gudmap.org/About/Tutorial/DevMUS.html#DMK_Nephron, MP:0005325, Wikipedia:Glomerulus] subset: pheno_slim synonym: "glomerular capillary tuft" RELATED [] synonym: "glomerulus" RELATED INCONSISTENT [EMAPA:28239] xref: EMAPA:28239 xref: Wikipedia:Glomerulus is_a: UBERON:0000064 ! organ part is_a: UBERON:0004120 ! mesoderm-derived structure relationship: BFO:0000050 UBERON:0001230 ! part of glomerular capsule relationship: RO:0002202 UBERON:0003220 {source="Wikipedia"} ! develops from metanephric mesenchyme relationship: RO:0002216 GO:0003094 ! capable of part of glomerular filtration [Term] id: UBERON:0005750 name: glomerular parietal epithelium def: "A single layer of simple squamous epithelium in the glomerular capsule. Does not function in filtration[UBERON]. outer layer of the glomerular capsule composed of a single layer of simple squamous epithelium[MP]." [https://orcid.org/0000-0002-6601-2165, MP:0011498] subset: human_reference_atlas subset: pheno_slim subset: vertebrate_core synonym: "Bowman's parietal epithelium" EXACT [MP:0011498] synonym: "capsular epithelium" EXACT [BTO:0002296] synonym: "glomerular capsule parietal layer" EXACT [FMA:74272] synonym: "kidney parietal epithelium" RELATED [EMAPA:35969] synonym: "outer layer of glomerular capsule" EXACT [FMA:74272] synonym: "parietal capsular epithelium" EXACT [MP:0011498] synonym: "parietal epithelial layer" EXACT [ZFA:0005253] synonym: "parietal epithelium of Bowman's capsule" EXACT [MP:0011498] synonym: "parietal layer of Bowman capsule" EXACT [] synonym: "parietal layer of Bowman's capsule" EXACT [MP:0011498] synonym: "parietal layer of glomerular capsule" EXACT [FMA:74272, MP:0011498] synonym: "renal glomerular capsule epithelium" EXACT [ZFA:0005253] xref: BTO:0002296 xref: EMAPA:27979 xref: EMAPA:28260 xref: EMAPA:35969 xref: FMA:74272 xref: MA:0002605 xref: NCIT:C33271 xref: SCTID:362218005 xref: TAO:0005253 xref: UMLS:C0227645 {source="ncithesaurus:Parietal_Layer_of_Bowman_s_Capsule"} xref: ZFA:0005253 is_a: UBERON:0000487 ! simple squamous epithelium is_a: UBERON:0004188 ! glomerular epithelium relationship: BFO:0000050 UBERON:0001230 ! part of glomerular capsule relationship: RO:0002220 UBERON:0001286 ! adjacent to Bowman's space property_value: IAO:0000116 "TODO - check this. BTO has podocytes under here" xsd:string property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0005751 name: glomerular visceral epithelium def: "The inner (visceral) layer of the renal glomerular capsule, overlying the capillaries, composed of podocytes, and separated from the outer (parietal) layer by the capsular (Bowman's) space[BTO]. This epithelial layer is superficially adjacent to the thickened glomerular basement membrane and is made of podocytes. Beneath the visceral layer lie the glomerular capillaries[WP]. This inner epithelial layer of the glomerular capsule surrounds the capillary endothelial cells and is composed of highly specialized epithelial cells (podocytes) that are separated by filtration slits; the inner visceral layer is separated from the outer parietal layer by the urinary space (also known as the Bowman's or capsular space)[MP]." [BTO:0001515, MP:0011497] comment: Formerly had rdfs:label 'visceral layer of glomerular capsule'. The current label 'glomerular visceral epithelium' was copied from UBERON:0006852, which is now obsolete since it represented the same entity as this IRI. subset: human_reference_atlas subset: inconsistent_with_fma subset: pheno_slim synonym: "Bowman's visceral epithelium" EXACT [MP:0011497] synonym: "glomerular capsule visceral layer" EXACT [MP:0011497] synonym: "inner epithelial layer of Bowman's capsule" EXACT [http://www.gudmap.org/About/Tutorial/DevMUS.html#DMK_Nephron] synonym: "podocyte layer of Bowman's capsule" EXACT [http://www.gudmap.org/About/Tutorial/DevMUS.html#DMK_Nephron] synonym: "visceral epithelium of Bowman's capsule" EXACT [http://www.gudmap.org/About/Tutorial/DevMUS.html#DMK_Nephron, MP:0011497] synonym: "visceral layer of Bowman's capsule" EXACT [MP:0011497] synonym: "visceral layer of glomerular capsule" EXACT [MP:0011497] xref: EMAPA:28254 xref: FMA:74273 xref: MA:0002607 xref: NCIT:C33879 xref: SCTID:244093000 xref: UMLS:C0227644 {source="ncithesaurus:Visceral_Layer_of_Bowman_s_Capsule"} is_a: UBERON:0004188 ! glomerular epithelium relationship: BFO:0000050 UBERON:0001230 ! part of glomerular capsule relationship: BFO:0000051 CL:0000653 ! has part podocyte relationship: RO:0002220 UBERON:0001286 ! adjacent to Bowman's space relationship: RO:0002433 UBERON:0001230 ! contributes to morphology of glomerular capsule property_value: IAO:0000116 "TODO - check - the BTO class 'glomerular epithelium' is the visceral layer. But GO uses 'glomerular epithelium' as the mereological sum of P+V layers" xsd:string property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0005753 name: caudal part of nephrogenic cord def: "The metanephros develops from the most caudal part of the nephrogenic cord that is itself derived from the intermediate plate mesoderm." [http://www.gudmap.org/About/Tutorial/DevMUS.html#DMK_Nephron] synonym: "caudal portion of nephrogenic cord" EXACT [OBOL:automatic] synonym: "caudal region of nephrogenic cord" EXACT [OBOL:automatic] synonym: "rear part of nephrogenic cord" EXACT [OBOL:automatic] synonym: "rear portion of nephrogenic cord" EXACT [Wikipedia:Metanephros#Metanephros] is_a: UBERON:0002050 ! embryonic structure relationship: BFO:0000050 UBERON:0004875 ! part of nephrogenic cord [Term] id: UBERON:0005754 name: rostral part of nephrogenic cord def: "The initial renal anlage that develops from the most rostral part of the nephrogenic cord is termed the pronephros." [http://www.gudmap.org/About/Tutorial/DevMUS.html#DMK_Nephron] is_a: UBERON:0002050 ! embryonic structure relationship: BFO:0000050 UBERON:0004875 ! part of nephrogenic cord [Term] id: UBERON:0005760 name: urorectal septum def: "The ridge of mesoderm covered with endoderm that in the early developing embryo partitions the endodermal cloaca into the primary urogenital sinus (ventrally) and the anorectal canal of the hindgut (dorsally); the urorectal septum eventually fuses with the cloacal membrane, dividing it into a dorsal anal membrane and a larger ventral urogenital membrane - this area of fusion is represented in the adult by the perineal body[MP]." [MP:anna, Wikipedia:Urorectal_septum] subset: pheno_slim synonym: "cloacal septum" RELATED [VHOG:0000018] synonym: "septum urorectale" EXACT OMO:0003011 [Wikipedia:Urorectal_septum] synonym: "urorectal fold" EXACT [MP:anna] synonym: "urorectal membrane" EXACT [MP:anna] xref: EHDAA2:0002152 xref: EHDAA:5921 xref: EMAPA:17212 xref: MA:0003235 xref: NCIT:C34323 xref: UMLS:C1519838 {source="ncithesaurus:Urorectal_Septum"} xref: VHOG:0000018 xref: Wikipedia:Urorectal_septum is_a: UBERON:0003037 ! septum relationship: BFO:0000050 UBERON:0001008 {source="MA"} ! part of renal system relationship: BFO:0000050 UBERON:0012361 {source="EHDAA2"} ! part of internal anal region relationship: RO:0002162 NCBITaxon:7742 ! in taxon Vertebrata property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/f/fb/Gray992.png" xsd:anyURI property_value: IAO:0000116 "todo - use to define cloacal septation in GO" xsd:string [Term] id: UBERON:0005764 name: acellular membrane def: "An acellular anatomical structure that is the bounding layer of a anatomical structure." [OBOL:automatic] subset: common_anatomy xref: FMA:63871 is_a: UBERON:0000476 ! acellular anatomical structure intersection_of: UBERON:0000476 ! acellular anatomical structure intersection_of: RO:0002007 UBERON:0000061 ! bounding layer of anatomical structure relationship: RO:0002007 UBERON:0000061 ! bounding layer of anatomical structure property_value: RO:0002175 NCBITaxon:33090 property_value: RO:0002175 NCBITaxon:33208 property_value: RO:0002175 NCBITaxon:4751 property_value: skos:prefLabel "acellular membrane" xsd:string [Term] id: UBERON:0005769 name: basement membrane of epithelium def: "An acellular membrane that is part of the epithelium, lies adjacent to the epithelial cells, and is the fusion of the the basal lamina and the reticular lamina." [http://orcid.org/0000-0002-6601-2165, Wikipedia:Basement_membrane] synonym: "basement membrane" RELATED [FMA:63872] synonym: "basement membrane of connective tissue" EXACT [FMA:63872] synonym: "membrana basalis" EXACT OMO:0003011 [Wikipedia:Basement_membrane] xref: AAO:0010596 xref: FMA:63872 xref: GAID:915 xref: NCIT:C13191 xref: SCTID:68989006 xref: UMLS:C0004799 {source="ncithesaurus:Basement_Membrane"} xref: Wikipedia:Basement_membrane is_a: UBERON:0005764 {source="FMA"} ! acellular membrane relationship: BFO:0000050 UBERON:0000483 ! part of epithelium relationship: BFO:0000051 GO:0005587 ! has part collagen type IV trimer relationship: RO:0002220 CL:0000066 ! adjacent to epithelial cell relationship: RO:0002473 GO:0005604 ! composed primarily of basement membrane property_value: RO:0002175 NCBITaxon:80999 {source="http://palaeos.com/metazoa/porifera/homoscleromorpha.html"} property_value: skos:prefLabel "basement membrane of epithelium" xsd:string [Term] id: UBERON:0005777 name: glomerular basement membrane def: "The layer of extracellular matrix that lies between the endothelium of the glomerular capillaries and the podocytes of the inner or visceral layer of the Bowman capsule; it is a fusion of the endothelial cell and podocyte basal laminas and acts as a physical barrier and an ion-selective filter." [MGI:anna, MP:0011348] subset: pheno_slim subset: vertebrate_core synonym: "GBM" BROAD OMO:0003000 [] synonym: "glomerular capillary basement membrane" EXACT [MA:0001659] synonym: "glomerular filtration membrane" EXACT [ZFA:0005285] xref: EMAPA:28251 xref: EMAPA:30965 xref: FMA:74274 xref: MA:0001659 xref: NCIT:C32683 xref: SCTID:243897006 xref: TAO:0005285 xref: UMLS:C0599297 {source="ncithesaurus:Glomerular_Basement_Membrane"} xref: Wikipedia:Glomerular_basement_membrane xref: ZFA:0005285 is_a: UBERON:0005769 ! basement membrane of epithelium intersection_of: UBERON:0005769 ! basement membrane of epithelium intersection_of: BFO:0000050 UBERON:0000074 ! part of renal glomerulus relationship: BFO:0000050 UBERON:0004188 {is_inferred="true", source="https://github.com/obophenotype/uberon/wiki/Inferring-part-of-relationships"} ! part of glomerular epithelium relationship: RO:0002215 GO:0003094 ! capable of glomerular filtration property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/d/de/PhysiologieGlom%C3%A9rulaire.png" xsd:anyURI [Term] id: UBERON:0005787 name: lamina densa of glomerular basement membrane def: "Middle layer of the glomerular basement membrane." [ZFIN:curator] subset: vertebrate_core synonym: "lamina densa" BROAD [ZFA:0005286] synonym: "lamina densa of glomerular basement membrane" EXACT [FMA:74276] synonym: "middle layer of glomerular basement membrane" EXACT [FMA:74276] xref: FMA:74276 xref: NCIT:C32916 xref: TAO:0005286 xref: UMLS:C1235665 {source="ncithesaurus:Lamina_Densa"} xref: ZFA:0005286 is_a: UBERON:0005764 ! acellular membrane intersection_of: UBERON:0005764 ! acellular membrane intersection_of: BFO:0000050 UBERON:0005777 ! part of glomerular basement membrane intersection_of: RO:0002220 UBERON:0005788 ! adjacent to lamina rara interna intersection_of: RO:0002220 UBERON:0005789 ! adjacent to lamina rara externa relationship: BFO:0000050 UBERON:0005777 ! part of glomerular basement membrane relationship: RO:0002220 UBERON:0005788 ! adjacent to lamina rara interna relationship: RO:0002220 UBERON:0005789 ! adjacent to lamina rara externa relationship: RO:0002473 GO:0005604 ! composed primarily of basement membrane [Term] id: UBERON:0005788 name: lamina rara interna def: "Layer of the glomerular basement membrane adjacent to the glomerular capillary." [ZFIN:curator] subset: vertebrate_core synonym: "internal layer of glomerular basement membrane" EXACT [FMA:74277] synonym: "lamina interna of glomerular basement membrane" EXACT [FMA:74277] xref: FMA:74277 xref: NCIT:C32920 xref: TAO:0005287 xref: UMLS:C1517719 {source="ncithesaurus:Lamina_Rara_Interna"} xref: ZFA:0005287 is_a: UBERON:0000476 ! acellular anatomical structure intersection_of: UBERON:0000476 ! acellular anatomical structure intersection_of: BFO:0000050 UBERON:0005777 ! part of glomerular basement membrane intersection_of: RO:0002220 UBERON:0001230 ! adjacent to glomerular capsule relationship: BFO:0000050 UBERON:0005777 ! part of glomerular basement membrane relationship: RO:0002220 UBERON:0001230 ! adjacent to glomerular capsule [Term] id: UBERON:0005789 name: lamina rara externa def: "Layer of the glomerular basement membrane adjacent to the podocytes and capsular space." [ZFIN:curator] subset: vertebrate_core synonym: "external layer of glomerular basement membrane" EXACT [FMA:74275] synonym: "lamina externa of glomerular basement membrane" EXACT [FMA:74275] xref: FMA:74275 xref: NCIT:C32919 xref: TAO:0005288 xref: UMLS:C1517718 {source="ncithesaurus:Lamina_Rara_Externa"} xref: ZFA:0005288 is_a: UBERON:0000476 ! acellular anatomical structure intersection_of: UBERON:0000476 ! acellular anatomical structure intersection_of: BFO:0000050 UBERON:0005777 ! part of glomerular basement membrane intersection_of: RO:0002220 UBERON:0001286 ! adjacent to Bowman's space relationship: BFO:0000050 UBERON:0005777 ! part of glomerular basement membrane relationship: RO:0002220 UBERON:0001286 ! adjacent to Bowman's space [Term] id: UBERON:0005792 name: nephric ridge def: "Nephric tubules (nephrons) form embryonically along the nephric ridge. The ridge comprises three regions; anterior, middle and posterior. The functional kidney uses nephrons from only one or two regions of the ridge. A pronephric kidney uses only the nephrons from the anterior region of the ridge. A mesonephric kidney uses only the middle region, a metanephric kidney uses only the posterior region and an opisthonephric kidney uses the middle and posterior regions." [http://cwx.prenhall.com/bookbind/pubbooks/martini10/chapter27/custom2/deluxe-content.html] synonym: "nephric cord" RELATED [VHOG:0001240] xref: EHDAA2:0001242 xref: EHDAA:1015 xref: EMAPA:16368 xref: VHOG:0001240 is_a: UBERON:0002050 ! embryonic structure relationship: BFO:0000050 UBERON:0001008 ! part of renal system relationship: BFO:0000050 UBERON:0004122 ! part of genitourinary system property_value: IAO:0000116 "TODO - check ridge vs cord vs nephrogenic cord vs blastema" xsd:string [Term] id: UBERON:0005795 name: embryonic uterus synonym: "fetal uterus" EXACT [FMA:72173] xref: FMA:72173 xref: SCTID:255782009 is_a: UBERON:0006598 ! presumptive structure relationship: RO:0002387 UBERON:0000995 ! has potential to develop into uterus [Term] id: UBERON:0005800 name: section of aorta def: "Any portion of the aorta including the ascending and descending aorta, and aortic arch or a portion of the aortic orifice of the left ventricle." [ncithesaurus:Aortic_Segment] synonym: "aortic section" EXACT [] synonym: "aortic segment" RELATED [FMA:13087] synonym: "portion of aorta" RELATED [] synonym: "segment of aorta" RELATED [FMA:13087] xref: FMA:13087 xref: NCIT:C34027 xref: SCTID:119203005 xref: UMLS:C0506947 {source="ncithesaurus:Aortic_Segment"} is_a: UBERON:0013522 ! subdivision of tube relationship: BFO:0000050 UBERON:0000947 ! part of aorta property_value: skos:prefLabel "section of aorta" xsd:string [Term] id: UBERON:0005805 name: dorsal aorta def: "The dorsal aorta is a blood vessel in a single-pass circulatory system that carries oxygenated blood from the gills to the rest of the body. In a single-pass circulatory system blood passes once through the heart to supply the body once." [GO:0035907, https://sourceforge.net/p/geneontology/ontology-requests/8525/] subset: vertebrate_core synonym: "aorta dorsalis" EXACT OMO:0003011 [XAO:0000051] synonym: "aortae dorsales" RELATED OMO:0003011 [Wikipedia:Dorsal_aorta] synonym: "DA" EXACT [ZFA:0000014] synonym: "dorsal aorta root" RELATED [VHOG:0000264] synonym: "dorsal aortae" RELATED OMO:0003004 [Wikipedia:Dorsal_aorta] synonym: "dorsal aortic root" RELATED [VHOG:0000264] synonym: "dorsal aortæ" RELATED OMO:0003004 [Wikipedia:Dorsal_aorta] xref: AAO:0011029 xref: BTO:0004673 xref: EHDAA:402 xref: EMAPA:18606 xref: SCTID:338637006 xref: TAO:0000014 xref: VHOG:0000264 xref: Wikipedia:Dorsal_aorta xref: XAO:0000051 xref: ZFA:0000014 is_a: UBERON:0000947 ! aorta is_a: UBERON:0003513 ! trunk blood vessel is_a: UBERON:0004120 ! mesoderm-derived structure relationship: BFO:0000050 UBERON:0002201 ! part of vasculature of trunk relationship: RO:0002202 UBERON:0001917 ! develops from endothelium of artery relationship: RO:0002202 UBERON:0003064 ! develops from intermediate mesoderm property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/f/fb/Gray459.png" xsd:anyURI property_value: skos:prefLabel "dorsal aorta" xsd:string [Term] id: UBERON:0005806 name: portal system def: "In the circulatory system of animals, a portal venous system occurs when a capillary bed drains into another capillary bed through veins, without first going through the heart. Both capillary beds and the blood vessels that connect them are considered part of the portal venous system. They are relatively uncommon as the majority of capillary beds drain into veins which then drain into the heart, not into another capillary bed. Portal venous systems are considered venous because the blood vessels that join the two capillary beds are either veins or venules. Examples of such systems include the hepatic portal system and the hypophyseal portal system. Unqualified, 'portal venous system' often refers to the hepatic portal system. For this reason, 'portal vein' most commonly refers to the hepatic portal vein[WP]." [Wikipedia:Portal_venous_system] synonym: "portal venous system" EXACT [FMA:45628] xref: FMA:45628 xref: MESH:D011168 xref: NCIT:C33344 xref: SCTID:362063001 xref: UMLS:C0226727 {source="ncithesaurus:Portal_Venous_System"} xref: Wikipedia:Portal_venous_system is_a: UBERON:0002049 ! vasculature property_value: skos:prefLabel "portal system" xsd:string [Term] id: UBERON:0005808 name: bone tissue of long bone def: "A bone tissue that is part of a long bone." [OBOL:automatic] synonym: "osseous tissue of long bone" RELATED [FMA:83117] xref: FMA:83117 xref: SCTID:425475006 is_a: UBERON:0002481 ! bone tissue intersection_of: UBERON:0002481 ! bone tissue intersection_of: BFO:0000050 UBERON:0002495 ! part of long bone relationship: BFO:0000050 UBERON:0002495 ! part of long bone [Term] id: UBERON:0005809 name: cortex of manus bone def: "The outer or sperficial part of a bone of the manus." [PHENOSCAPE:ad] is_a: UBERON:0001439 ! compact bone tissue is_a: UBERON:0003598 ! manus connective tissue intersection_of: UBERON:0001439 ! compact bone tissue intersection_of: BFO:0000050 UBERON:0005897 ! part of manus bone relationship: BFO:0000050 UBERON:0005897 ! part of manus bone [Term] id: UBERON:0005813 name: tubercle def: "A round nodule, small eminence, or warty outgrowth on an anatomical surface, such as bones, skin, or within the lungs (in the case of tuberculosis). They are also found on the leading edge of Humpback Whale's flippers, improving fluid flow over the flipper's surface[WP]." [Wikipedia:Tubercle_(anatomy)] subset: grouping_class subset: upper_level synonym: "tuber" RELATED [] xref: AAO:0010605 xref: BTO:0002173 xref: FMA:75429 xref: Wikipedia:Tubercle_(anatomy) is_a: UBERON:0004529 ! anatomical projection [Term] id: UBERON:0005814 name: arch of atlas def: "A vertebral arch that is part of the first cervical vertebra." [http://orcid.org/0000-0002-6601-2165] synonym: "atlas arch" EXACT [FMA:23975] xref: FMA:23975 xref: SCTID:272708001 xref: Wikipedia:Arch_of_the_atlas is_a: UBERON:0010358 ! arch of centrum of vertebra intersection_of: UBERON:0010358 ! arch of centrum of vertebra intersection_of: BFO:0000050 UBERON:0001092 ! part of vertebral bone 1 relationship: BFO:0000050 UBERON:0001092 ! part of vertebral bone 1 [Term] id: UBERON:0005837 name: fasciculus of spinal cord def: "A fascicle that is part of a spinal cord." [OBOL:automatic] synonym: "spinal cord fasciculus" EXACT [FMA:75799] xref: FMA:75799 is_a: UBERON:0001019 ! nerve fasciculus is_a: UBERON:0011215 ! central nervous system cell part cluster intersection_of: UBERON:0001019 ! nerve fasciculus intersection_of: BFO:0000050 UBERON:0002240 ! part of spinal cord relationship: BFO:0000050 UBERON:0002240 ! part of spinal cord property_value: skos:prefLabel "fasciculus of spinal cord" xsd:string [Term] id: UBERON:0005838 name: fasciculus of brain def: "A fascicle that is part of a brain." [OBOL:automatic] synonym: "brain fasciculus" EXACT [FMA:83844] xref: FMA:83844 is_a: UBERON:0001019 ! nerve fasciculus is_a: UBERON:0011215 ! central nervous system cell part cluster intersection_of: UBERON:0001019 ! nerve fasciculus intersection_of: BFO:0000050 UBERON:0000955 ! part of brain relationship: BFO:0000050 UBERON:0000955 ! part of brain relationship: BFO:0000050 UBERON:0002316 ! part of white matter property_value: skos:prefLabel "fasciculus of brain" xsd:string [Term] id: UBERON:0005843 name: sacral spinal cord def: "A spinal cord segment that adjacent_to a sacral region." [OBOL:automatic] subset: human_reference_atlas synonym: "pars sacralis medullae spinalis" EXACT OMO:0003011 [FMA:256623, FMA:TA] synonym: "sacral segment of spinal cord" EXACT [FMA:256623] synonym: "sacral segments of spinal cord [1-5]" EXACT [FMA:256623] synonym: "segmenta sacralia medullae spinalis [1-5]" EXACT OMO:0003011 [FMA:256623, FMA:TA] xref: BIRNLEX:1275 xref: FMA:256623 xref: MA:0003085 xref: NCIT:C12896 xref: SCTID:244438003 xref: UMLS:C0581669 {source="BIRNLEX:1275", source="ncithesaurus:Sacral_Spinal_Cord"} xref: UMLS:C1280196 {source="BIRNLEX:1275"} is_a: UBERON:0005844 ! spinal cord segment intersection_of: UBERON:0005844 ! spinal cord segment intersection_of: RO:0002220 UBERON:0005473 ! adjacent to sacral region relationship: RO:0002220 UBERON:0005473 ! adjacent to sacral region property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0005844 name: spinal cord segment synonym: "axial part of spinal cord" EXACT [BIRNLEX:2665] synonym: "axial regional part of spinal cord" EXACT [BIRNLEX:2665] synonym: "segment of spinal cord" EXACT [FMA:62420] synonym: "spinal neuromeres" RELATED OMO:0003004 [TAO:0001332] xref: BIRNLEX:2665 xref: FMA:62420 xref: MA:0003080 xref: SCTID:278748001 is_a: UBERON:0001948 ! regional part of spinal cord property_value: IAO:0000116 "This is currently used loosely to refer to cervical, lumbar, etc as well as the metamerically repeated segments, which may correspond more closely with the ZFA neuromere term" xsd:string property_value: skos:prefLabel "spinal cord segment" xsd:string [Term] id: UBERON:0005845 name: caudal segment of spinal cord def: "A spinal cord segment that adjacent_to a caudal region." [OBOL:automatic] comment: for spinal cord segments, we treat coccygeal/caudal as synonyms - we only differentiate where bone is concerned synonym: "coccygeal segment of spinal cord" EXACT [FMA:256635] synonym: "coccygeal segments of spinal cord [1-3]" EXACT [FMA:256635] synonym: "pars coccygea medullae spinalis" EXACT OMO:0003011 [FMA:256635, FMA:TA] synonym: "segmenta coccygea" RELATED OMO:0003011 [NeuroNames:1656] synonym: "segmenta coccygea medullae spinalis [1-3]" EXACT OMO:0003011 [FMA:256635, FMA:TA] xref: FMA:256635 xref: MA:0003084 xref: neuronames:1656 xref: SCTID:278753006 is_a: UBERON:0005844 ! spinal cord segment intersection_of: UBERON:0005844 ! spinal cord segment intersection_of: RO:0002220 UBERON:0006071 ! adjacent to caudal region relationship: RO:0002220 UBERON:0006071 ! adjacent to caudal region property_value: skos:prefLabel "caudal segment of spinal cord" xsd:string [Term] id: UBERON:0005856 name: developing mesenchymal condensation def: "A delimited region of dense mesenchyme within looser mesenchyme." [AEO:0000148] synonym: "mesenchyme condensation" EXACT [EMAPA:25351] xref: AEO:0000148 xref: EHDAA2_RETIRED:0003148 xref: EHDAA:8979 is_a: UBERON:0007524 {source="AEO"} ! dense mesenchyme tissue is_a: UBERON:0011585 {source="cjm"} ! cell condensation relationship: RO:0002473 CL:0000335 {source="AEO-modified-relation"} ! composed primarily of mesenchyme condensation cell property_value: skos:prefLabel "developing mesenchymal condensation" xsd:string [Term] id: UBERON:0005863 name: cartilaginous condensation def: "Cell condensation that is an aggregation of mesenchymal cells that are committed to differentiate into chondroblasts and chondrocytes." [GO:curator] synonym: "cartilage condensation" EXACT [EMAPA:25353] synonym: "cartilagenous condensation" EXACT [EHDAA2:0003147] synonym: "chondrogenic condensation" EXACT [VSAO:0000092] xref: AEO:0000147 xref: EHDAA2_RETIRED:0003147 xref: EMAPA:32731 xref: VSAO:0000092 xref: XAO:0004022 is_a: UBERON:0005856 {source="AEO"} ! developing mesenchymal condensation relationship: BFO:0000050 UBERON:0004288 {source="AEO"} ! part of skeleton relationship: RO:0002202 UBERON:0005866 ! develops from pre-cartilage condensation property_value: skos:prefLabel "cartilaginous condensation" xsd:string [Term] id: UBERON:0005865 name: pre-muscle condensation synonym: "pre muscle mass" EXACT [] synonym: "premuscle mass" EXACT [] xref: AEO:0000149 xref: EHDAA2_RETIRED:0003149 is_a: UBERON:0005856 ! developing mesenchymal condensation intersection_of: UBERON:0005856 ! developing mesenchymal condensation intersection_of: RO:0002473 CL:0000680 ! composed primarily of muscle precursor cell relationship: RO:0002387 UBERON:0005090 ! has potential to develop into muscle structure relationship: RO:0002473 CL:0000680 ! composed primarily of muscle precursor cell property_value: skos:prefLabel "pre-muscle condensation" xsd:string [Term] id: UBERON:0005866 name: pre-cartilage condensation def: "A delimited region of dense mesenchyme within looser mesenchyme whose cells are committed to become chondroblasts." [AEO:0000150, AEO:JB] synonym: "pre-chondrogenic condensation" EXACT [] synonym: "precartilage condensation" EXACT [] synonym: "precartilagenous condensation" EXACT [] synonym: "prechondrogenic condensation" EXACT [] xref: AEO:0000150 xref: EHDAA2:0003150 xref: EMAPA:32736 is_a: UBERON:0005291 ! embryonic tissue is_a: UBERON:0005856 {source="AEO"} ! developing mesenchymal condensation relationship: BFO:0000050 UBERON:0004288 {source="AEO"} ! part of skeleton relationship: RO:0002387 UBERON:0007844 ! has potential to develop into cartilage element property_value: skos:prefLabel "pre-cartilage condensation" xsd:string [Term] id: UBERON:0005867 name: mandibular prominence def: "The paired ventral prominences formed by bifurcation of the first pharyngeal arches in the embryo; the two prominences unite ventrally and fuse to form the mandible and lower lip." [ISBN:0-683-40008-8, MP:0010939] subset: pheno_slim synonym: "mandibular process" RELATED [Wikipedia:Mandibular_prominence] synonym: "mandibular swelling" RELATED [https://orcid.org/0000-0002-6601-2165] synonym: "prominentia mandibularis" RELATED OMO:0003011 [Wikipedia:Mandibular_prominence] xref: EHDAA2:0001061 xref: EHDAA:5871 xref: EMAPA:17355 xref: FMA:293051 xref: NCIT:C34204 xref: UMLS:C1512982 {source="ncithesaurus:Mandibular_Prominence"} xref: Wikipedia:Mandibular_prominence is_a: BFO:0000002 is_a: UBERON:0012314 ! embryonic facial prominence relationship: BFO:0000050 UBERON:0000166 ! part of oral opening relationship: RO:0002202 UBERON:0007237 ! develops from 1st arch mandibular component property_value: IAO:0000116 "check develops_from" xsd:string property_value: skos:prefLabel "mandibular prominence" xsd:string [Term] id: UBERON:0005868 name: maxillary prominence def: "The paired dorsal prominences formed by bifurcation of the first pharyngeal arches in the embryo that unite with the ipsilateral medial nasal process to form the upper jaw." [ISBN:0-683-40008-8, MP:0010940] subset: pheno_slim synonym: "embryonic maxillary process" EXACT [] synonym: "maxillary process" EXACT [EHDAA2:0001070] synonym: "maxillary process of embryo" EXACT [] synonym: "prominentia maxilaris" RELATED OMO:0003011 [Wikipedia:Maxillary_prominence] xref: EHDAA2:0001070 xref: EHDAA:5877 xref: EMAPA:17359 xref: FMA:293049 xref: NCIT:C34206 xref: SCTID:346355001 xref: UMLS:C1513037 {source="ncithesaurus:Maxillary_Prominence"} xref: Wikipedia:Maxillary_prominence is_a: BFO:0000002 is_a: UBERON:0002050 ! embryonic structure relationship: RO:0002202 UBERON:0007238 ! develops from 1st arch maxillary component property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/2/2d/Gray48.png" xsd:anyURI property_value: skos:prefLabel "maxillary prominence" xsd:string [Term] id: UBERON:0005870 name: olfactory pit def: "An indentation of the olfactory placode which ends when the pits hollows out to form the nasopharynx[GO]." [GO:0060166, Wikipedia:Nasal_pit] subset: efo_slim subset: pheno_slim synonym: "nasal pit" EXACT [XAO:0000275] xref: AAO:0011068 xref: EFO:0003496 xref: EHDAA2:0001295 xref: EHDAA:4772 xref: EMAPA:16800 xref: FMA:295840 xref: SCTID:361485001 xref: Wikipedia:Nasal_pit xref: XAO:0000275 xref: XAO:0004073 is_a: BFO:0000002 is_a: UBERON:0016566 {source="EHDAA2"} ! pit relationship: BFO:0000050 UBERON:0000004 {source="EMAPA"} ! part of nose relationship: BFO:0000050 UBERON:0000922 ! part of embryo relationship: RO:0001025 UBERON:0005384 {source="EHDAA2"} ! located in nasal cavity epithelium relationship: RO:0002202 UBERON:0003050 {source="XAO:0000275 nasal pit"} ! develops from olfactory placode property_value: IAO:0000116 "we represent the relationship as develops from, though in fact the pit is formed as an indentation in the placode" xsd:string [Term] id: UBERON:0005872 name: 1st arch pharyngeal cleft def: "A groove that is situated between the 1st and 2nd pharyngeal arch." [ISBN:0124020607, VHOG:OG] subset: vertebrate_core synonym: "1st arch branchial groove" EXACT [EHDAA2:0000008] synonym: "1st arch groove ectoderm" EXACT [EHDAA2:0000009] synonym: "1st branchial cleft" RELATED [EMAPA:16119] synonym: "1st pharyngeal cleft" RELATED [VHOG:0000969] synonym: "1st pharyngeal groove" EXACT [VHOG:0000969] synonym: "1st pharyngeal groove ectoderm" EXACT [VHOG:0000554] synonym: "branchial groove of 1st arch" EXACT [EMAPA:16119] xref: EHDAA2:0000009 xref: EHDAA:575 xref: EMAPA:16119 xref: VHOG:0000554 xref: VHOG:0000969 is_a: UBERON:0005879 ! pharyngeal cleft intersection_of: UBERON:0005879 ! pharyngeal cleft intersection_of: RO:0002131 UBERON:0003066 ! overlaps pharyngeal arch 2 intersection_of: RO:0002131 UBERON:0004362 ! overlaps pharyngeal arch 1 relationship: RO:0002131 UBERON:0003066 ! overlaps pharyngeal arch 2 relationship: RO:0002131 UBERON:0004362 ! overlaps pharyngeal arch 1 [Term] id: UBERON:0005873 name: 2nd arch pharyngeal cleft def: "A groove that is situated between the 2nd and 3rd pharyngeal arch." [ISBN:0124020607, VHOG:OG] subset: vertebrate_core synonym: "2nd arch branchial groove" EXACT [EHDAA2:0000054] synonym: "2nd arch groove ectoderm" EXACT [EHDAA2:0000057] synonym: "2nd branchial cleft" RELATED [EMAPA:16396] synonym: "2nd pharyngeal cleft" RELATED [VHOG:0000972] synonym: "2nd pharyngeal groove" EXACT [VHOG:0000972] synonym: "2nd pharyngeal groove ectoderm" EXACT [VHOG:0000568] synonym: "branchial groove of 2nd arch" EXACT [EMAPA:16396] xref: EHDAA2:0000057 xref: EHDAA:613 xref: EMAPA:16396 xref: VHOG:0000568 xref: VHOG:0000972 is_a: UBERON:0005879 ! pharyngeal cleft intersection_of: UBERON:0005879 ! pharyngeal cleft intersection_of: RO:0002131 UBERON:0003066 ! overlaps pharyngeal arch 2 intersection_of: RO:0002131 UBERON:0003114 ! overlaps pharyngeal arch 3 relationship: RO:0002131 UBERON:0003066 ! overlaps pharyngeal arch 2 relationship: RO:0002131 UBERON:0003114 ! overlaps pharyngeal arch 3 [Term] id: UBERON:0005874 name: 3rd arch pharyngeal cleft def: "A groove that is situated between the 3rd and 4th pharyngeal arch." [ISBN:0124020607, VHOG:OG] subset: vertebrate_core synonym: "3rd arch branchial groove" EXACT [EHDAA2:0000071] synonym: "3rd arch groove ectoderm" EXACT [EHDAA2:0000074] synonym: "3rd branchial cleft" RELATED [EMAPA:16581] synonym: "3rd pharyngeal cleft" RELATED [VHOG:0000973] synonym: "3rd pharyngeal groove" EXACT [VHOG:0000973] synonym: "3rd pharyngeal groove ectoderm" EXACT [VHOG:0000572] synonym: "branchial groove of 3rd arch" EXACT [EMAPA:16581] xref: EHDAA2:0000074 xref: EHDAA:1082 xref: EMAPA:16581 xref: VHOG:0000572 xref: VHOG:0000973 is_a: UBERON:0005879 ! pharyngeal cleft intersection_of: UBERON:0005879 ! pharyngeal cleft intersection_of: RO:0002131 UBERON:0003114 ! overlaps pharyngeal arch 3 intersection_of: RO:0002131 UBERON:0003115 ! overlaps pharyngeal arch 4 relationship: RO:0002131 UBERON:0003114 ! overlaps pharyngeal arch 3 relationship: RO:0002131 UBERON:0003115 ! overlaps pharyngeal arch 4 [Term] id: UBERON:0005875 name: 4th arch pharyngeal cleft def: "A groove that is situated between the 4th and 5th pharyngeal arch." [ISBN:0124020607, VHOG:OG] subset: vertebrate_core synonym: "4th arch branchial groove" EXACT [RETIRED_EHDAA2:0000088] synonym: "4th arch pharyngeal groove ectoderm" EXACT [EHDAA2:0000089] synonym: "4th branchial cleft" RELATED [EMAPA:16761] synonym: "4th pharyngeal cleft" RELATED [VHOG:0000968] synonym: "4th pharyngeal groove" EXACT [VHOG:0000968] synonym: "4th pharyngeal groove ectoderm" EXACT [VHOG:0000577] synonym: "branchial groove of 4th arch" EXACT [EMAPA:16761] xref: EHDAA2:0000089 xref: EHDAA:1665 xref: EMAPA:16761 xref: RETIRED_EHDAA2:0000088 xref: VHOG:0000577 xref: VHOG:0000968 is_a: UBERON:0005879 ! pharyngeal cleft intersection_of: UBERON:0005879 ! pharyngeal cleft intersection_of: RO:0002131 UBERON:0003115 ! overlaps pharyngeal arch 4 intersection_of: RO:0002131 UBERON:0003116 ! overlaps pharyngeal arch 5 relationship: RO:0002131 UBERON:0003115 ! overlaps pharyngeal arch 4 relationship: RO:0002131 UBERON:0003116 ! overlaps pharyngeal arch 5 [Term] id: UBERON:0005876 name: undifferentiated genital tubercle def: "The embryonic anlage of the external genitalia, which emerges as paired swellings ventral to the cloacal membrane, is proposed to be derived from all three germ layers, and gives rise to the penis, clitoris, scrotum, labia, and foreskin." [https://github.com/obophenotype/uberon/issues/1230, MGI:anna, MP:0011771] subset: pheno_slim synonym: "genital tubercle" RELATED [EMAPA:17382] synonym: "phallic tubercle" RELATED [] synonym: "tuberculum genitale" RELATED OMO:0003011 [Wikipedia:Genital_tubercle] synonym: "tuberculum phallicum" RELATED OMO:0003011 [Wikipedia:Genital_tubercle] synonym: "undifferentiated genital tubercle" EXACT [VHOG:0000583] xref: EHDAA2:0000705 xref: EHDAA:5925 xref: EMAPA:17382 xref: FMA:302888 xref: SCTID:308798005 xref: VHOG:0000583 xref: Wikipedia:Genital_tubercle is_a: BFO:0000002 is_a: UBERON:0002050 ! embryonic structure relationship: BFO:0000050 UBERON:0009196 {source="EHDAA2"} ! part of indifferent external genitalia relationship: RO:0002202 UBERON:0004874 ! develops from somatopleure relationship: RO:0002387 UBERON:0011757 ! has potential to develop into differentiated genital tubercle property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/d/d6/Gray1119.png" xsd:anyURI [Term] id: UBERON:0005879 name: pharyngeal cleft def: "An external pocketing of pharyngeal ectoderm that contacts a region of endoderm (a pharyngeal pouch) and interdigitates in the anterior and posterior directions by the pharyngeal arches." [http://orcid.org/0000-0002-6601-2165, PMID:23020903] subset: pheno_slim synonym: "branchial cleft" RELATED [Wikipedia:Pharyngeal_groove] synonym: "branchial groove" RELATED [AAO:0010623, Wikipedia:Pharyngeal_groove] synonym: "gill cleft" NARROW [] synonym: "Kiemenspalten" RELATED [] synonym: "pharyngeal ectodermal cleft" RELATED [] synonym: "pharyngeal groove" BROAD [Wikipedia:Pharyngeal_groove] synonym: "pharyngeal groove ectoderm" EXACT [https://orcid.org/0000-0002-6601-2165] synonym: "pharyngeal slit" RELATED INCONSISTENT [] synonym: "sulcus pharyngei" RELATED OMO:0003011 [Wikipedia:Pharyngeal_groove] xref: AAO:0010623 xref: EMAPA:32750 xref: FMA:295672 xref: NCIT:C34250 xref: UMLS:C1280559 {source="ncithesaurus:Pharyngeal_Groove"} xref: Wikipedia:Pharyngeal_groove is_a: BFO:0000004 is_a: UBERON:0006846 {source="EHDAA2"} ! surface groove relationship: BFO:0000050 UBERON:0016545 ! part of pharyngeal ectoderm relationship: RO:0002131 UBERON:0002539 ! overlaps pharyngeal arch relationship: RO:0002220 UBERON:0004117 ! adjacent to pharyngeal pouch property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/2/20/Kiemenbogen.jpg" xsd:anyURI property_value: IAO:0000116 "Note we use overlaps as the relationship to the arches" xsd:string [Term] id: UBERON:0005881 name: autopodial extension def: "A subdivision of the autopod that corresponds to one or more bones arranged in series branching from the main limb axis." [http://orcid.org/0000-0002-6601-2165] comment: encompasses digits and prepollex. requires review synonym: "digit or predigit" RELATED [] synonym: "limb outgrowth" RELATED [] is_a: UBERON:0000475 ! organism subdivision relationship: BFO:0000050 UBERON:0002470 ! part of autopod region [Term] id: UBERON:0005882 name: neural tube alar plate def: "The mantle layer of the neural tube that lies dorsal to the sulcus limitans and contains primarily sensory neurons and interneurons involved in communication of sensory impulses." [http://www.ncbi.nlm.nih.gov/books/NBK10047, MP:0009692, Wikipedia:Alar_plate] synonym: "alar lamina" RELATED [Wikipedia:Alar_lamina] synonym: "alar plate" EXACT [NeuroNames:1370] synonym: "alar plate of neural tube" EXACT [] synonym: "dorsal part of neural tube" RELATED [] synonym: "lamina alaris" RELATED OMO:0003011 [Wikipedia:Alar_plate] synonym: "lamina dorsolateralis" RELATED OMO:0003011 [Wikipedia:Alar_plate] synonym: "sensory part of neural tube" RELATED [] xref: neuronames:1370 xref: Wikipedia:Alar_plate is_a: UBERON:0002050 ! embryonic structure relationship: BFO:0000050 UBERON:0004061 ! part of neural tube mantle layer relationship: BFO:0000051 CL:0000101 ! has part sensory neuron relationship: BSPO:0000098 UBERON:0005478 ! sulcus limitans of neural tube property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/2/29/Gray646.png" xsd:anyURI property_value: seeAlso "https://github.com/obophenotype/uberon/issues/336" xsd:anyURI property_value: skos:prefLabel "neural tube alar plate" xsd:string [Term] id: UBERON:0005884 name: hyoid arch skeleton def: "A subdivision of skeleton that supports pharyngeal arch 2." [OBOL:automatic] synonym: "hyoid arch" RELATED INCONSISTENT [TAO:0001276] synonym: "hyoid arch skeleton" EXACT [ZFA:0001276] synonym: "hyoid bars" NARROW [TAO:0001276] synonym: "pharyngeal arch 2 skeleton" EXACT [ZFA:0001276] synonym: "visceral arch 2" RELATED INCONSISTENT [TAO:0001276] xref: AAO:0000665 xref: AAO:0010370 xref: TAO:0001276 xref: XAO:0003177 xref: ZFA:0001276 is_a: BFO:0000002 is_a: UBERON:0010912 ! subdivision of skeleton relationship: BFO:0000050 UBERON:0008895 {source="ZFA"} ! part of splanchnocranium relationship: RO:0002202 UBERON:0003066 {source="cjm"} ! develops from pharyngeal arch 2 property_value: skos:prefLabel "hyoid arch skeleton" xsd:string [Term] id: UBERON:0005891 name: coelomic epithelium def: "The epithelial lining of the surface of the coelom." [Wikipedia:Coelomic_epithelium, XAO:0000329] synonym: "celomic epithelium" EXACT [] synonym: "germinal epithelium of Waldeyer" EXACT [Wikipedia:Coelomic_epithelium] xref: Wikipedia:Coelomic_epithelium xref: XAO:0000329 is_a: BFO:0000002 is_a: UBERON:0000483 ! epithelium relationship: BFO:0000050 UBERON:0011997 ! part of coelom relationship: RO:0001025 UBERON:0002323 ! located in coelemic cavity lumen relationship: RO:0002254 UBERON:0004871 {source="XAO"} ! has developmental contribution from somatic layer of lateral plate mesoderm relationship: RO:0002254 UBERON:0004872 {source="XAO"} ! has developmental contribution from splanchnic layer of lateral plate mesoderm [Term] id: UBERON:0005893 name: leg bone def: "A bone that is part of the region of the hindlimb that includes the zeugopod and stylopod. Examples: patella, femur, tibia. Counter-examples: any pes phalanx." [https://orcid.org/0000-0002-6601-2165] subset: grouping_class subset: human_reference_atlas xref: EMAPA:37304 {source="MA:th"} xref: MA:0000670 xref: MESH:D007867 is_a: UBERON:0003464 ! hindlimb bone intersection_of: UBERON:0001474 ! bone element intersection_of: BFO:0000050 UBERON:0000978 ! part of leg relationship: BFO:0000050 UBERON:0000978 ! part of leg property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0005897 name: manus bone def: "A bone that is part of the manus skeleton. Note that this includes the carpal bones." [https://orcid.org/0000-0002-6601-2165] subset: human_reference_atlas synonym: "bone of hand" EXACT [] synonym: "bone of hand skeleton" EXACT [] synonym: "bone of manus" EXACT [] synonym: "bone of pectoral limb autopod" EXACT [] synonym: "bone of pectoral limb autopodium" EXACT [] synonym: "forelimb autopod bone" EXACT [] synonym: "forelimb autopodium bone" EXACT [] synonym: "hand bone" EXACT [MA:0000619] xref: EMAPA:35391 xref: MA:0000619 xref: SCTID:426741001 is_a: UBERON:0008962 ! forelimb bone is_a: UBERON:0011250 ! autopod bone intersection_of: UBERON:0001474 ! bone element intersection_of: BFO:0000050 UBERON:0002398 ! part of manus relationship: BFO:0000050 UBERON:0001442 ! part of skeleton of manus property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0005899 name: pes bone def: "A bone that is part of the pes skeleton." [https://orcid.org/0000-0002-6601-2165] subset: human_reference_atlas synonym: "bone of foor proper or tarsal skeleton" EXACT [] synonym: "bone of foot" EXACT [] synonym: "bone of pedal skeleton" EXACT [] synonym: "bone of pes" EXACT [] synonym: "foot bone" EXACT [MA:0000643] xref: EMAPA:35354 xref: GAID:192 xref: MA:0000643 xref: MESH:D005529 xref: NCIT:C13068 xref: SCTID:361371005 xref: UMLS:C0016505 {source="ncithesaurus:Foot_Bone"} is_a: UBERON:0003464 ! hindlimb bone is_a: UBERON:0011250 ! autopod bone intersection_of: UBERON:0001474 ! bone element intersection_of: BFO:0000050 UBERON:0002387 ! part of pes relationship: BFO:0000050 UBERON:0001445 ! part of skeleton of pes property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0005902 name: occipital region def: "Anatomical cluster that is located in the posterior region of the cranium and forms the margin of the foramen magnum and occipital condyles." [TAO:0001414, UBERONREF:0000007] synonym: "back of head" RELATED [FMA:49187] synonym: "basicranial region" EXACT [ZFA:0001414] synonym: "occipital part of head" EXACT [FMA:49187] synonym: "occipital region of head" EXACT [FMA:49187] xref: AAO:0010199 xref: BTO:0004675 xref: FMA:49187 xref: MESH:D009778 {sssom:mapping_justification="https://w3id.org/semapv/vocab/LexicalMatching"} xref: neuronames:2431 xref: SCTID:362618001 xref: TAO:0001414 xref: XAO:0003173 xref: ZFA:0001414 is_a: UBERON:0034921 ! multi organ part structure relationship: BFO:0000050 UBERON:0003128 ! part of cranium property_value: IAO:0000116 "TODO - check" xsd:string property_value: skos:prefLabel "occipital region" xsd:string [Term] id: UBERON:0005903 name: duct of seminal vesicle def: "Each seminal vesicle consists of a single tube, coiled upon itself, and giving off several irregular cecal diverticula; the separate coils, as well as the diverticula, are connected together by fibrous tissue. When uncoiled, the tube is about the diameter of a quill, and varies in length from 10 to 15 cm.; it ends posteriorly in a cul-de-sac; its anterior extremity becomes constricted into a narrow straight duct called the excretory duct of seminal gland (or duct of the seminal vesicle), which joins with the corresponding ductus deferens to form the ejaculatory duct[WP]." [Wikipedia:Excretory_duct_of_seminal_gland] synonym: "ductus excretorius (vesicula seminalis)" EXACT [FMA:19473] synonym: "ductus excretorius glandulae vesiculosae" EXACT OMO:0003011 [FMA:19473, FMA:TA] synonym: "ductus excretorius glandulae vesiculosae" RELATED OMO:0003011 [Wikipedia:Excretory_duct_of_seminal_gland] synonym: "excretory duct of seminal gland" EXACT [FMA:19473] synonym: "seminal vesicle duct" EXACT [FMA:19473] xref: EMAPA:29282 xref: FMA:19473 xref: SCTID:279675008 xref: Wikipedia:Excretory_duct_of_seminal_gland is_a: UBERON:0000025 ! tube is_a: UBERON:0005904 ! duct of male reproductive system intersection_of: UBERON:0000058 ! duct intersection_of: BFO:0000050 UBERON:0000998 ! part of seminal vesicle relationship: BFO:0000050 UBERON:0000998 ! part of seminal vesicle relationship: channel_for UBERON:0010143 ! seminal vesicle fluid relationship: channels_into UBERON:0000999 ! ejaculatory duct property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/9/97/Gray1160.png" xsd:anyURI [Term] id: UBERON:0005904 name: duct of male reproductive system def: "Any of the ducts that are part of a male reproductive system." [http://orcid.org/0000-0002-6601-2165] subset: grouping_class is_a: UBERON:0000058 ! duct is_a: UBERON:0005156 ! reproductive structure intersection_of: UBERON:0000058 ! duct intersection_of: BFO:0000050 UBERON:0000079 ! part of male reproductive system relationship: BFO:0000050 UBERON:0000079 ! part of male reproductive system [Term] id: UBERON:0005906 name: serous sac def: "Organ with organ cavity, which has as parts a serous membrane and a serous cavity . Examples: pleural sac, pericardial sac, tendon sheath, bursa.[FMA]." [FMA:9689, https://github.com/obophenotype/uberon/issues/86] comment: See notes for serous membrane xref: FMA:9689 xref: SCTID:362890006 is_a: BFO:0000002 is_a: UBERON:0000062 ! organ relationship: BFO:0000051 UBERON:0000042 ! has part serous membrane relationship: BFO:0000051 UBERON:0002553 ! has part anatomical cavity property_value: skos:prefLabel "serous sac" xsd:string property_value: terms:contributor https://orcid.org/0000-0002-6601-2165 [Term] id: UBERON:0005908 name: conjunctival sac def: "A serous sac which is the aggregate of the conjunctiva plus the conjunctival space." [https://github.com/obophenotype/uberon/wiki/Serous-Membranes-Design-Pattern] synonym: "conjunctiva serous sac" EXACT [] synonym: "subbrillar sac" NARROW [NCBITaxon:8570] xref: EMAPA:18233 xref: FMA:20291 xref: SCTID:362531001 is_a: UBERON:0005906 {source="FMA"} ! serous sac relationship: BFO:0000050 UBERON:0000019 {source="FMA"} ! part of camera-type eye relationship: BFO:0000050 UBERON:0035639 {source="HPO:pr"} ! part of ocular adnexa relationship: RO:0002220 UBERON:0001801 ! adjacent to anterior segment of eyeball [Term] id: UBERON:0005911 name: endo-epithelium def: "Epithelium that derives from the endoderm. Examples: urothelium, transitional epithelium of ureter, epithelium of prostatic gland.[FMA]." [FMA:69065] synonym: "endoderm-derived epithelium" EXACT [] synonym: "endoepithelium" EXACT [] xref: FMA:69065 is_a: UBERON:0000483 ! epithelium is_a: UBERON:0004119 ! endoderm-derived structure intersection_of: UBERON:0000483 ! epithelium intersection_of: RO:0002202 UBERON:0000925 ! develops from endoderm property_value: skos:prefLabel "endo-epithelium" xsd:string [Term] id: UBERON:0005913 name: zone of bone organ synonym: "bone organ zone" EXACT [FMA:10483] xref: FMA:10483 is_a: BFO:0000002 is_a: UBERON:0034944 {source="FMA"} ! zone of organ relationship: BFO:0000050 UBERON:0001474 ! part of bone element relationship: RO:0002473 UBERON:0002481 ! composed primarily of bone tissue property_value: skos:prefLabel "zone of bone organ" xsd:string [Term] id: UBERON:0005928 name: external naris def: "A naris that provides one of the small external openings of the head that give passage to air for breathing." [http://orcid.org/0000-0002-6601-2165, Wikipedia:Nostril] subset: pheno_slim subset: vertebrate_core synonym: "anterior nares" RELATED OMO:0003004 [VHOG:0000544] synonym: "anterior naris" RELATED [ZFA:0001427] synonym: "blowhole" NARROW [Wikipedia:Blowhole_(anatomy)] synonym: "external nares" EXACT OMO:0003004 [] synonym: "naris" BROAD [ZFA:0000550] synonym: "nostril" EXACT [FMA:59645, XAO:0003033] xref: AAO:0000024 xref: AAO:0000983 xref: AAO:0010358 xref: EHDAA2:0001275 xref: EHDAA:9085 xref: EMAPA:17848 xref: FMA:59645 xref: MA:0001320 xref: NCIT:C33178 xref: SCTID:276165005 xref: TAO:0000550 xref: UMLS:C0595944 {source="ncithesaurus:Nostril"} xref: VHOG:0000544 xref: Wikipedia:Nostril xref: XAO:0003033 xref: ZFA:0000550 is_a: UBERON:0000003 ! naris is_a: UBERON:0003102 {source="ZFA"} ! surface structure intersection_of: UBERON:0000003 ! naris intersection_of: RO:0002176 UBERON:0001707 ! connects nasal cavity intersection_of: RO:0002176 UBERON:0013514 ! connects space surrounding organism relationship: BFO:0000050 UBERON:0000004 ! part of nose relationship: RO:0002176 UBERON:0013514 ! connects space surrounding organism relationship: RO:0002216 GO:0007585 ! capable of part of respiratory gaseous exchange by respiratory system relationship: RO:0002433 UBERON:0000004 ! contributes to morphology of nose [Term] id: UBERON:0005932 name: bulb of hair follicle def: "Thickening of the proximal end of the hair follicle. Contains rapidly proliferating, rather undifferentiated matrix cells (transient amplifying cells), melanocytes and outer root sheath cells." [DOI:10.1016/j.cub.2008.12.005] subset: human_reference_atlas subset: pheno_slim synonym: "coat hair bulb" NARROW SENSU [MA:0000161] synonym: "hair bulb" EXACT [FMA:70666] synonym: "hair follicle bulb" EXACT [FMA:70666] xref: EMAPA:18770 xref: FMA:70666 xref: MA:0000161 xref: NCIT:C32706 xref: SCTID:361360009 xref: UMLS:C0221962 {source="ncithesaurus:Hair_Bulb"} is_a: UBERON:0000479 ! tissue relationship: BFO:0000050 UBERON:0002073 ! part of hair follicle property_value: RO:0002175 NCBITaxon:9606 property_value: seeAlso "https://github.com/obophenotype/mouse-anatomy-ontology/issues/56" xsd:anyURI [Term] id: UBERON:0005933 name: hair root sheath xref: EMAPA:18772 xref: FMA:294628 xref: MA:0000162 is_a: UBERON:0000479 ! tissue relationship: BFO:0000050 UBERON:0005932 ! part of bulb of hair follicle property_value: seeAlso "https://github.com/obophenotype/mouse-anatomy-ontology/issues/56" xsd:anyURI [Term] id: UBERON:0005941 name: hair inner root sheath def: "A multilayered tube composed of terminally differentiated hair follicle keratinocytes that is surrounded by the outer root sheath; the layers of the inner root sheath include the companion layer, Henle's layer, Huxley's layer and the inner root sheath cuticle[MP]." [https://github.com/obophenotype/mouse-anatomy-ontology/issues/56, MP:0010685] subset: human_reference_atlas subset: pheno_slim synonym: "hair follicle inner root sheath" EXACT [MP:0010685] synonym: "inner root sheath" RELATED [BTO:0003971] synonym: "inner root sheath of hair follicle" EXACT [FMA:70935] synonym: "inner sheath of hair follicle" EXACT [FMA:70935] synonym: "internal root sheath of hair follicle" EXACT [FMA:70935] xref: BTO:0003971 xref: EMAPA:32792 xref: FMA:70935 xref: MA:0000779 is_a: BFO:0000002 is_a: UBERON:0005933 ! hair root sheath relationship: BFO:0000051 CL:0000312 ! has part keratinocyte property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0005942 name: hair outer root sheath def: "A stratified epithelium that surrounds the hair follicle that merges proximally with the basal layer of the interfollicular epidermis and distally with the hair bulb." [DOI:10.1016/j.cub.2008.12.005, http://www.keratin.com/aa/aa022.shtml, https://github.com/obophenotype/mouse-anatomy-ontology/issues/56] subset: human_reference_atlas subset: pheno_slim synonym: "external root sheath of hair follicle" EXACT [FMA:70943] synonym: "hair follicle outer root sheath" EXACT [BTO:0003969] synonym: "ORS" RELATED [BTO:0003969] synonym: "outer hair sheath" RELATED [] synonym: "outer root sheath" RELATED [BTO:0003969] synonym: "outer root sheath of hair follicle" EXACT [FMA:70943] xref: BTO:0003969 xref: EMAPA:32793 xref: FMA:70943 xref: MA:0000780 xref: NCIT:C62490 xref: SCTID:319224003 xref: Wikipedia:Outer_root_sheath is_a: UBERON:0005933 ! hair root sheath relationship: RO:0002150 UBERON:0005932 ! continuous with bulb of hair follicle property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0005944 name: axial skeleton plus cranial skeleton def: "Subdivision of skeleton which consists of cranial skeleton, set of all vertebrae, set of all ribs and sternum[FMA, modified]." [FMA:71221, https://github.com/obophenotype/uberon/issues/44, https://github.com/obophenotype/uberon/wiki/The-axial-skeleton, VSAO:0000056, Wikipedia:Axial_skeleton] subset: human_reference_atlas subset: pheno_slim subset: uberon_slim synonym: "skeleton axiale" RELATED OMO:0003011 [Wikipedia:Axial_skeleton] xref: AAO:0000963 xref: EMAPA:17214 xref: MA:0000308 xref: NCIT:C32172 xref: SCTID:361725000 xref: UMLS:C0222645 {source="ncithesaurus:Axial_Skeleton"} xref: VSAO:0000056 xref: Wikipedia:Axial_skeleton xref: XAO:0004011 is_a: BFO:0000002 is_a: UBERON:0010912 ! subdivision of skeleton relationship: BFO:0000050 UBERON:0011137 ! part of axial skeletal system relationship: RO:0002202 UBERON:0003089 ! develops from sclerotome relationship: RO:0002433 UBERON:0001434 ! contributes to morphology of skeletal system property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/8/8b/Axial_skeleton_diagram.svg" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 property_value: seeAlso "http://purl.obolibrary.org/obo/uberon/docs/The-axial-skeleton" xsd:anyURI property_value: skos:prefLabel "axial skeleton plus cranial skeleton" xsd:string property_value: terms:contributor https://orcid.org/0000-0002-6601-2165 [Term] id: UBERON:0005945 name: neurocranial trabecula subset: efo_slim synonym: "neurocranial trabeculae" EXACT OMO:0003004 [ZFA:0001321] synonym: "trabecula" BROAD SENSU [ZFA:0001321] synonym: "trabecular cartilage" BROAD [ZFA:0001321] xref: EFO:0003677 xref: TAO:0001321 xref: ZFA:0001321 is_a: UBERON:0000440 ! trabecula is_a: UBERON:0003932 {source="ZFA"} ! cartilage element of chondrocranium relationship: BFO:0000050 UBERON:0003112 {source="ZFA"} ! part of olfactory region property_value: skos:prefLabel "neurocranial trabecula" xsd:string [Term] id: UBERON:0005946 name: outflow tract of atrium def: "An outflow tract that is part of a cardiac atrium." [OBOL:automatic] synonym: "outflow part of atrium" EXACT [FMA:14141] xref: FMA:14141 is_a: UBERON:0004145 ! outflow tract intersection_of: UBERON:0004145 ! outflow tract intersection_of: BFO:0000050 UBERON:0002081 ! part of cardiac atrium relationship: BFO:0000050 UBERON:0002081 ! part of cardiac atrium relationship: RO:0002150 UBERON:0002082 ! continuous with cardiac ventricle property_value: skos:prefLabel "outflow tract of atrium" xsd:string [Term] id: UBERON:0005953 name: outflow part of right ventricle def: "Anteriosuperior, smooth-walled portion of the cavity of the right ventricle, beginning at the supraventricular crest and terminating in the pulmonary trunk." [MP:0010428] synonym: "arterial cone" RELATED [MP:0010428] synonym: "conus arteriosus" RELATED [MP:0010428] synonym: "conus arteriosus (infundibulum)" EXACT [FMA:7216] synonym: "infundibulum" BROAD [Wikipedia:Conus_arteriosus] synonym: "infundibulum of right ventricle" EXACT [FMA:7216, MP:0010428] synonym: "outflow tract of right ventricle" EXACT [FMA:7216] synonym: "pulmonary cone" RELATED [MP:0010428] synonym: "pulmonary conus" EXACT [FMA:7216] synonym: "pulmonary conus" RELATED [MP:0010428] synonym: "right ventricle pulmonary outflow tract" EXACT [MP:0010428] synonym: "right ventricular outflow tract" EXACT [MP:0010428] synonym: "RVOT" EXACT OMO:0003000 [MP:0010428] xref: EMAPA:37926 {source="MA:th"} xref: FMA:7216 xref: NCIT:C61368 xref: SCTID:244379003 xref: UMLS:C1881209 {source="ncithesaurus:Infundibulum"} is_a: BFO:0000002 is_a: UBERON:0005337 ! outflow tract of ventricle intersection_of: UBERON:0005337 ! outflow tract of ventricle intersection_of: BFO:0000050 UBERON:0002080 ! part of heart right ventricle relationship: BFO:0000050 UBERON:0002080 ! part of heart right ventricle relationship: RO:0002150 UBERON:0002333 ! continuous with pulmonary trunk relationship: RO:0002202 UBERON:0009889 {source="PMID:17276708"} ! develops from secondary heart field property_value: skos:prefLabel "outflow part of right ventricle" xsd:string [Term] id: UBERON:0005956 name: outflow part of left ventricle def: "Anterosuperior fibrous portion of the left ventricle that connects to the ascending aorta." [MP:0010429] subset: pheno_slim synonym: "aortic vestibule" EXACT [FMA:9473, MP:0010429] synonym: "heart left ventricle outflow tract" EXACT [MP:0010429] synonym: "left ventricular outflow" EXACT [FMA:9473] synonym: "left ventricular outflow tract" EXACT [HP:0011103] synonym: "LVOT" EXACT OMO:0003000 [MP:0010429] synonym: "outflow tract of left ventricle" EXACT [FMA:9473] synonym: "Sibson vestibule" EXACT [MP:0010429] synonym: "vestibulum aortae" EXACT OMO:0003011 [FMA:9473, FMA:TA] xref: EMAPA:37925 {source="MA:th"} xref: FMA:9473 xref: SCTID:264070001 xref: Wikipedia:Aortic_vestibule is_a: UBERON:0005337 ! outflow tract of ventricle intersection_of: UBERON:0005337 ! outflow tract of ventricle intersection_of: BFO:0000050 UBERON:0002084 ! part of heart left ventricle relationship: BFO:0000050 UBERON:0002084 ! part of heart left ventricle property_value: skos:prefLabel "outflow part of left ventricle" xsd:string [Term] id: UBERON:0005965 name: outflow part of right atrium def: "Outflow part of atrium which consists of wall and cavity of the outflow part of right atrium and the tricuspid valve.[FMA]." [FMA:9550, FMA:FMA] synonym: "main part of right atrium" EXACT [FMA:9550] synonym: "outflow tract of right atrium" EXACT [FMA:9550] xref: FMA:9550 is_a: UBERON:0005946 ! outflow tract of atrium intersection_of: UBERON:0005946 ! outflow tract of atrium intersection_of: BFO:0000050 UBERON:0002078 ! part of right cardiac atrium relationship: BFO:0000050 UBERON:0002078 ! part of right cardiac atrium property_value: skos:prefLabel "outflow part of right atrium" xsd:string [Term] id: UBERON:0005966 name: outflow part of left atrium def: "An outflow tract of atrium that is part of a left atrium." [OBOL:automatic] synonym: "main part of left atrium" EXACT [FMA:9551] synonym: "outflow tract of left atrium" EXACT [FMA:9551] xref: FMA:9551 is_a: UBERON:0005946 ! outflow tract of atrium intersection_of: UBERON:0005946 ! outflow tract of atrium intersection_of: BFO:0000050 UBERON:0002079 ! part of left cardiac atrium relationship: BFO:0000050 UBERON:0002079 ! part of left cardiac atrium property_value: skos:prefLabel "outflow part of left atrium" xsd:string [Term] id: UBERON:0005969 name: eye trabecular meshwork def: "A pore-like structure surrounding the entire circumference of the anterior chamber of the eye through which aqueous humor circulates[MP]." [MP:0005203, Wikipedia:Trabecular_meshwork] subset: efo_slim subset: pheno_slim synonym: "cribiform ligament" RELATED [Wikipedia:Trabecular_meshwork] synonym: "eye trabecular meshwork" EXACT [MA:0003086] synonym: "Hueck's ligament" RELATED [BTO:0001605] synonym: "iridis" RELATED [Wikipedia:Trabecular_meshwork] synonym: "ligamentum peactin-tum iridis" RELATED [Wikipedia:Trabecular_meshwork] synonym: "ligamentum pectinatum" RELATED [Wikipedia:Trabecular_meshwork] synonym: "ligamentum pectinatum anguli iridocornealis" RELATED [BTO:0001605] synonym: "ligamentum pectinatum iridis" RELATED [Wikipedia:Trabecular_meshwork] synonym: "pectinate ligament" RELATED [BTO:0001605] synonym: "pectinate ligament of iris" RELATED [BTO:0001605] synonym: "reticulum trabeculare" EXACT [BTO:0001605] synonym: "reticulum trabeculare sclerae" RELATED OMO:0003011 [Wikipedia:Trabecular_meshwork] synonym: "scleral trabeculae" RELATED [Wikipedia:Trabecular_meshwork] synonym: "scleral trabecular" RELATED [Wikipedia:Trabecular_meshwork] synonym: "scleral trabecule" RELATED [Wikipedia:Trabecular_meshwork] synonym: "scribiform ligament" RELATED [Wikipedia:Trabecular_meshwork] synonym: "trabecular mesh" RELATED [Wikipedia:Trabecular_meshwork] synonym: "trabecular meshwork" RELATED [BTO:0001605, GO:0002930] synonym: "trabecular meshwork of the eye" EXACT [Wikipedia:Trabecular_meshwork] xref: BTO:0001605 xref: CALOHA:TS-1058 xref: EFO:0003077 xref: EV:0100352 xref: FMA:77660 xref: GAID:897 xref: MA:0003086 xref: MESH:D014129 xref: NCIT:C12803 xref: SCTID:280694002 xref: UMLS:C0040573 {source="ncithesaurus:Trabecular_Meshwork"} xref: Wikipedia:Trabecular_meshwork is_a: UBERON:0000479 ! tissue relationship: BFO:0000050 UBERON:0003956 ! part of aqueous drainage system relationship: BFO:0000051 CL:0002367 ! has part trabecular meshwork cell relationship: RO:0002131 UBERON:0006206 ! overlaps iridocorneal angle relationship: RO:0002221 UBERON:0001766 ! surrounds anterior chamber of eyeball property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/2/22/Gray870.png" xsd:anyURI property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/eye-female-left/v1.3/assets/3d-vh-f-eye-l.glb" xsd:anyURI property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/eye-female-right/v1.3/assets/3d-vh-f-eye-r.glb" xsd:anyURI property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/eye-male-left/v1.3/assets/3d-vh-m-eye-l.glb" xsd:anyURI property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/eye-male-right/v1.3/assets/3d-vh-m-eye-r.glb" xsd:anyURI property_value: IAO:0000116 "TODO check syns - ligaments" xsd:string [Term] id: UBERON:0005970 name: brain commissure def: "Any of the nerve fiber tracts that span the longitudinal fissure between the cerebral and/or cerebellar hemispheres of the brain." [https://github.com/obophenotype/uberon/issues/325, ISBN:0-683-40008-8, MGI:csmith, MP:0002199] subset: pheno_slim xref: EMAPA:37446 {source="MA:th"} is_a: UBERON:0001020 ! nervous system commissure is_a: UBERON:0007702 ! tract of brain intersection_of: UBERON:0001020 ! nervous system commissure intersection_of: BFO:0000050 UBERON:0000955 ! part of brain relationship: BSPO:0005001 UBERON:0000955 ! brain property_value: skos:prefLabel "brain commissure" xsd:string [Term] id: UBERON:0005971 name: amniotic fold def: "A sheet of somatopleure that grows upward over the embryo and eventually meets in the midline enclosing the embryo, eventually giving rise to the amnion and chorion[Kardong]." [ISBN:0073040584] subset: pheno_slim synonym: "amnionic fold" EXACT [http://placentation.ucsd.edu/glossfs.html] xref: EMAPA:16076 is_a: BFO:0000002 is_a: UBERON:0000478 ! extraembryonic structure relationship: RO:0002162 NCBITaxon:32524 ! in taxon Amniota relationship: RO:0002202 UBERON:0004874 {source="ISBN:0073040584"} ! develops from somatopleure [Term] id: UBERON:0005978 name: olfactory bulb outer nerve layer def: "Superficial layer of the main olfactory bulb containing axons from the olfactory nerve and glial cells." [NLXANAT:1005010] subset: pheno_slim synonym: "olfactory bulb main olfactory nerve layer" EXACT [NLXANAT:1005010] synonym: "olfactory bulb olfactory nerve layer" EXACT [MA:0003191] xref: DHBA:11326 xref: EMAPA:35614 xref: MA:0003191 xref: MBA:1016 xref: NLXANAT:1005010 is_a: UBERON:0004001 ! olfactory bulb layer relationship: BSPO:0001100 UBERON:0002264 ! olfactory bulb property_value: skos:prefLabel "olfactory bulb outer nerve layer" xsd:string [Term] id: UBERON:0005979 name: crista terminalis def: "The vertical crest of the interior wall of the right atrium that lies to the right of the sinus of the vena cava and separates this from the remainder of the right atrium." [MP:0010495] subset: pheno_slim synonym: "crista terminalis atrii dextri" EXACT OMO:0003011 [FMA:9236, FMA:TA] synonym: "crista terminalis cordis" EXACT [FMA:9236] synonym: "crista terminalis of right atrium" EXACT [FMA:9236] xref: EMAPA:37837 {source="MA:th"} xref: FMA:9236 xref: SCTID:277693004 xref: Wikipedia:Crista_terminalis is_a: UBERON:0000064 ! organ part relationship: BFO:0000050 UBERON:0002078 ! part of right cardiac atrium relationship: RO:0002433 UBERON:0002078 ! contributes to morphology of right cardiac atrium [Term] id: UBERON:0005983 name: heart layer def: "The laminar structure of the heart." [MP:0010545] subset: non_informative subset: pheno_slim is_a: UBERON:0004923 ! organ component layer intersection_of: UBERON:0004923 ! organ component layer intersection_of: BFO:0000050 UBERON:0000948 ! part of heart relationship: BFO:0000050 UBERON:0000948 ! part of heart relationship: RO:0002433 UBERON:0000948 ! contributes to morphology of heart property_value: skos:prefLabel "heart layer" xsd:string [Term] id: UBERON:0005985 name: coronary vessel def: "Any of the arteries or veins that supply blood to the heart or return blood from the heart muscles to the circulation." [MP:0010551] subset: pheno_slim xref: MESH:D003331 xref: Wikipedia:Coronary_circulation is_a: UBERON:0000055 ! vessel intersection_of: UBERON:0000055 ! vessel intersection_of: BFO:0000050 UBERON:0000948 ! part of heart relationship: BFO:0000050 UBERON:0000948 ! part of heart relationship: RO:0002433 UBERON:0000948 ! contributes to morphology of heart property_value: IAO:0000116 "TODO - change relation from part_of" xsd:string property_value: skos:prefLabel "coronary vessel" xsd:string [Term] id: UBERON:0005986 name: left bundle branch def: "The left branch of the atrioventricular bundle that separates at the bundle of His, descends the septal wall of the left ventricle and connects to the terminal Purkinje fiber[MP]." [MP:0010566] subset: pheno_slim synonym: "crus sinistrum (fasciculi atrioventricularis)" EXACT [FMA:9487] synonym: "crus sinistrum fasciculi atrioventricularis" EXACT OMO:0003011 [FMA:9487, FMA:TA] synonym: "LBB" EXACT OMO:0003000 [] synonym: "left branch of atrioventricular bundle" EXACT [] synonym: "left bundle branch" EXACT [MP:0010566] synonym: "left bundle branch of bundle of His" EXACT [HP:0005172] synonym: "left bundle of atrioventricular bundle" EXACT [MP:0010566] synonym: "left crus of atrioventricular bundle" EXACT [MP:0010566] synonym: "left posterior branch" EXACT [MP:0010566] synonym: "left posterior bundle" EXACT [MP:0010566] xref: EMAPA:37358 {source="MA:th"} xref: FMA:9487 xref: galen:LeftBundleBranch xref: SCTID:277690001 is_a: UBERON:0010131 ! conducting tissue of heart is_a: UBERON:0015212 ! lateral structure is_a: UBERON:0018649 ! cardiac muscle tissue of ventricle relationship: BSPO:0000120 UBERON:0002353 ! bundle of His [Term] id: UBERON:0005987 name: right bundle branch def: "The right branch of the atrioventricular bundle that separates just below the bundle of His, descends the septal wall of the right ventricle and connects to the terminal Purkinje fibers[MP]." [MP:0010567] subset: pheno_slim synonym: "crus dextrum (fasciculi atrioventricularis)" EXACT [FMA:9486] synonym: "crus dextrum fasciculi atrioventricularis" EXACT OMO:0003011 [FMA:9486, FMA:TA] synonym: "RBB" EXACT OMO:0003000 [] synonym: "right branch of atrioventricular bundle" EXACT [] synonym: "right bundle" EXACT [FMA:9486, MP:0010567] synonym: "right bundle branch" EXACT [FMA:9486] synonym: "right bundle branch of bundle of His" EXACT [] synonym: "right right crus of atrioventricular bundle" EXACT [MP:0010567] synonym: "right ventricular bundle" EXACT [MP:0010567] xref: EMAPA:37359 {source="MA:th"} xref: FMA:9486 xref: galen:RightBundleBranch xref: SCTID:277689005 is_a: UBERON:0010131 ! conducting tissue of heart is_a: UBERON:0015212 ! lateral structure is_a: UBERON:0018649 ! cardiac muscle tissue of ventricle relationship: BSPO:0000121 UBERON:0002353 ! bundle of His [Term] id: UBERON:0005988 name: atrium myocardial trabecula def: "The supporting bundles of muscular fibers lining the walls of the atrial myocardium." [MP:0010581, ZFA:0005810] subset: pheno_slim synonym: "atrial trabecula" EXACT [] synonym: "atrium myocardial trabeculae" EXACT OMO:0003004 [MP:0010581] synonym: "trabecula of atrium" EXACT [] synonym: "trabecular layer of atrium" EXACT [] synonym: "trabecular layer of the atrium" EXACT [ZFA:0005810] xref: EMAPA:37432 {source="MA:th"} xref: ZFA:0005810 is_a: UBERON:0000440 ! trabecula intersection_of: UBERON:0000440 ! trabecula intersection_of: BFO:0000050 UBERON:0002302 ! part of myocardium of atrium relationship: BFO:0000050 UBERON:0002302 ! part of myocardium of atrium relationship: BFO:0000050 UBERON:0004124 {source="ZFA"} ! part of myocardium trabecular layer relationship: RO:0002433 UBERON:0002302 ! contributes to morphology of myocardium of atrium property_value: skos:prefLabel "atrium myocardial trabecula" xsd:string [Term] id: UBERON:0005989 name: atrioventricular septum def: "The wall of the heart that separates the right atrium and left ventricle; and is located just above the septal cusp of the tricuspid valve." [MP:0010592] subset: pheno_slim synonym: "membranous atrioventricular septum" EXACT [FMA:7136] xref: EMAPA:37431 {source="MA:th"} xref: FMA:7136 xref: SCTID:280151006 xref: Wikipedia:Atrioventricular_septum is_a: UBERON:0002099 ! cardiac septum is_a: UBERON:0010313 ! neural crest-derived structure intersection_of: UBERON:0002099 ! cardiac septum intersection_of: RO:0002220 UBERON:0002078 ! adjacent to right cardiac atrium intersection_of: RO:0002220 UBERON:0002084 ! adjacent to heart left ventricle relationship: RO:0002202 UBERON:0002062 {source="PMID:15797462", source="Wikipedia"} ! develops from endocardial cushion relationship: RO:0002220 UBERON:0002078 ! adjacent to right cardiac atrium relationship: RO:0002220 UBERON:0002084 ! adjacent to heart left ventricle property_value: skos:prefLabel "atrioventricular septum" xsd:string [Term] id: UBERON:0006002 name: vitelline artery def: "The paired arteries that carry blood to the yolk sac from the dorsal aorta." [MP:0010664, Wikipedia:Vitelline_arteries] comment: Development notes:; the vitelline arteries give rise to the celiac artery, superior mesenteric artery, and inferior mesenteric artery in the adult[MP:0010664] subset: pheno_slim xref: EHDAA2:0002208 xref: EMAPA:16207 xref: Wikipedia:Vitelline_arteries is_a: UBERON:0001637 ! artery is_a: UBERON:0004365 ! vitelline blood vessel intersection_of: UBERON:0001637 ! artery intersection_of: RO:0020101 UBERON:0001040 ! vessel supplies blood to yolk sac relationship: RO:0002252 UBERON:0005805 ! connecting branch of dorsal aorta relationship: RO:0020101 UBERON:0001040 ! vessel supplies blood to yolk sac property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/5/55/Gray31.png" xsd:anyURI property_value: skos:prefLabel "vitelline artery" xsd:string [Term] id: UBERON:0006003 name: integumentary adnexa def: "Anatomical structure embedded in or located in the integument that is part of the integumental system. Examples: hair, follicles, skin glands, claws, nails, feathers." [http://code.google.com/p/caro2/issues/detail?id=5, http://orcid.org/0000-0002-6601-2165] subset: pheno_slim synonym: "adnexae cutis" RELATED OMO:0003011 [Wikipedia:Skin_appendage] synonym: "body hair or bristle" NARROW [GO:GO] synonym: "skin adnexa" RELATED [Wikipedia:Skin_appendage] synonym: "skin adnexal structure" RELATED [] synonym: "skin appendage" RELATED [Wikipedia:Skin_appendage] xref: EMAPA:37883 {source="MA:th"} xref: Wikipedia:Skin_appendage is_a: UBERON:0000064 ! organ part relationship: BFO:0000050 UBERON:0002416 ! part of integumental system property_value: IAO:0000116 "add subclasses based on resolution of CARO tracker item. Also check: adnexal gland. Note that MP implicitly includes hypodermis." xsd:string property_value: skos:prefLabel "integumentary adnexa" xsd:string [Term] id: UBERON:0006004 name: hair follicle matrix region def: "The bulb region adjacent to the dermal papilla that contains rapidly proliferating matrix cells that give rise to the various cell lineages of the hair shaft and inner root sheath." [MP:0010686] subset: pheno_slim synonym: "germinal matrix of hair bulb" EXACT [FMA:70772] synonym: "lower part of bulb of hair follicle" EXACT [FMA:70772] synonym: "lower zone of bulb of hair follicle" EXACT [FMA:70772] xref: EMAPA:37878 {source="MA:th"} xref: FMA:70772 is_a: BFO:0000002 is_a: UBERON:0019204 ! skin epithelium relationship: BFO:0000050 UBERON:0005932 ! part of bulb of hair follicle relationship: BFO:0000051 CL:0000148 {source="FMA"} ! has part melanocyte relationship: BFO:0000051 CL:0000453 {source="FMA"} ! has part Langerhans cell relationship: RO:0002220 UBERON:0000412 ! adjacent to dermal papilla relationship: RO:0002433 UBERON:0005932 ! contributes to morphology of bulb of hair follicle [Term] id: UBERON:0006005 name: hair follicle isthmus def: "The middle part of the hair follicle that extends from the sebaceous duct to the bulge." [DOI:10.1016/j.cub.2008.12.005, MP:0010694] subset: pheno_slim synonym: "isthmus of hair follicle" EXACT [FMA:70723] xref: EMAPA:37877 {source="MA:th"} xref: FMA:70723 xref: NCIT:C32709 xref: UMLS:C1182701 {source="ncithesaurus:Hair_Follicle_Isthmus"} is_a: UBERON:0019204 ! skin epithelium relationship: BFO:0000050 UBERON:0002073 ! part of hair follicle [Term] id: UBERON:0006008 name: fibrous ring of heart def: "A ring of ribrous tissue that surrounds the atrioventricular and arterial orifices." [http://orcid.org/0000-0002-6601-2165, Wikipedia:Fibrous_rings_of_heart] synonym: "annulus fibrosus cordis" RELATED OMO:0003011 [Wikipedia:Fibrous_rings_of_heart] synonym: "anulus fibrosus cordis" RELATED [Wikipedia:Fibrous_rings_of_heart] synonym: "anulus fibrosus of heart" EXACT [FMA:9497] synonym: "aortic annulus" RELATED [Wikipedia:Fibrous_rings_of_heart] synonym: "atrioventricular ring" RELATED [BTO:0003628] synonym: "coronary tendon" RELATED [BTO:0003628] synonym: "fibrous ring of heart" RELATED [Wikipedia:Fibrous_rings_of_heart] synonym: "Lower's ring" RELATED [BTO:0003628] xref: BTO:0003628 xref: EMAPA:37422 {source="MA:th"} xref: FMA:9497 xref: Wikipedia:Fibrous_rings_of_heart is_a: UBERON:0003837 ! thoracic segment connective tissue is_a: UBERON:0006444 ! annulus fibrosus intersection_of: UBERON:0006444 ! annulus fibrosus intersection_of: BFO:0000050 UBERON:0000948 ! part of heart relationship: BFO:0000050 UBERON:0000948 ! part of heart property_value: IAO:0000116 "TODO - compare with ZFA atrioventricular ring, part of the conduction system" xsd:string [Term] id: UBERON:0006056 name: posterior surface of head is_a: UBERON:0036215 ! anatomical surface region intersection_of: UBERON:0036215 ! anatomical surface region intersection_of: BSPO:0000122 UBERON:0000033 ! head relationship: BSPO:0000122 UBERON:0000033 ! head property_value: skos:prefLabel "posterior surface of head" xsd:string [Term] id: UBERON:0006058 name: multi-limb segment region def: "A collection of two or more connected limb segments. Examples: arm (comprising stylopod and zeugopod regions)." [https://orcid.org/0000-0002-6601-2165] subset: non_informative is_a: BFO:0000002 is_a: UBERON:0010758 ! subdivision of organism along appendicular axis relationship: BFO:0000051 UBERON:0002529 ! has part limb segment property_value: seeAlso "https://github.com/obophenotype/uberon/issues/514" xsd:anyURI [Term] id: UBERON:0006061 name: process of vertebra def: "A process projection from a part of the vertebra such as centrum or arches. Examples: transverse process, diapophyses, parapophyses, and zygapophyses (both the cranial zygapophyses and the caudal zygapophyses)." [Wikipedia:Vertebral_column#Structure_of_individual_vertebrae] synonym: "spinous process" NARROW [AAO:0000739] synonym: "vertebra process" EXACT [] synonym: "vertebral process" EXACT [FMA:24530] xref: AAO:0000739 xref: FMA:24530 xref: Wikipedia:Vertebral_column#Structure_of_individual_vertebrae is_a: UBERON:4100000 ! skeletal element projection relationship: BFO:0000050 UBERON:0002412 ! part of vertebra [Term] id: UBERON:0006063 name: cartilaginous neural arch def: "One of the cartilaginous structures surrounding the embryonic spinal cord, formed by the dorsal growth of the dorsolateral arcualia; it is the primordium of the vertebral arch." [BTO:0001763] synonym: "neural arch primordium" RELATED [] xref: BTO:0001763 is_a: BFO:0000002 is_a: UBERON:0010358 ! arch of centrum of vertebra relationship: BFO:0000050 UBERON:0000922 ! part of embryo relationship: BFO:0000051 UBERON:0002418 ! has part cartilage tissue [Term] id: UBERON:0006067 name: musculature of hindlimb zeugopod def: "Any collection of muscles that is part of a hindlimb zeugopod." [OBOL:automatic] subset: pheno_slim synonym: "leg musculature" EXACT [FMA:50211] synonym: "muscle group of leg" EXACT [FMA:50211] synonym: "set of muscles of leg" EXACT [FMA:50211] xref: FMA:50211 is_a: UBERON:0004466 ! musculature of leg intersection_of: UBERON:0001015 ! musculature intersection_of: BFO:0000050 UBERON:0003823 ! part of hindlimb zeugopod relationship: BFO:0000050 UBERON:0003823 ! part of hindlimb zeugopod [Term] id: UBERON:0006068 name: bone of tail def: "A bone that is part of a post-anal tail." [OBOL:automatic] subset: pheno_slim synonym: "tail bone" RELATED [MA:0000696] synonym: "tail vertebra" RELATED [http://orcid.org/0000-0002-6601-2165] xref: EMAPA:18042 xref: MA:0000696 is_a: UBERON:0001474 ! bone element intersection_of: UBERON:0001474 ! bone element intersection_of: BFO:0000050 UBERON:0007812 ! part of post-anal tail relationship: BFO:0000050 UBERON:0007812 ! part of post-anal tail property_value: skos:prefLabel "bone of tail" xsd:string [Term] id: UBERON:0006071 name: caudal region def: "Subdivision of an organism along anterior-posterior axis that is the posteriormost region, extending past the anus (or cloaca, if present), consisting of a tail in some fully formed chordates (or a tail bud in embryos). In animals that have a sacral region, this is the region immediately posterior to this." [http://orcid.org/0000-0002-6601-2165] synonym: "post-anal caudal region" RELATED [http://orcid.org/0000-0002-6601-2165] synonym: "post-anal tail region" RELATED [http://orcid.org/0000-0002-6601-2165] synonym: "postsacral region" RELATED [AAO:0000082] synonym: "tail region" RELATED [AAO:0000082] xref: XAO:0000087 is_a: UBERON:0011676 ! subdivision of organism along main body axis relationship: BFO:0000050 UBERON:0000154 ! part of posterior region of body relationship: BSPO:0000099 UBERON:0001245 ! anus relationship: RO:0002551 UBERON:0006076 ! has skeleton caudal region of vertebral column property_value: skos:prefLabel "caudal region" xsd:string [Term] id: UBERON:0006072 name: cervical region of vertebral column def: "That portion of the spine comprising the cervical vertebrae. The neck area of the spine." [http://medical-dictionary.thefreedictionary.com/] subset: pheno_slim synonym: "axial skeleton cervical region" EXACT [MA:0003154] synonym: "cervical skeleton" EXACT [EHDAA2:0000238] synonym: "cervical spinal column" EXACT [FMA:24138] synonym: "cervical spine" EXACT [FMA:24138] synonym: "cervical vertebrae series" EXACT [] synonym: "cervical vertebral column" EXACT [FMA:24138] synonym: "skeletal system of neck" RELATED [FMA:24138] xref: AAO:0000092 xref: BTO:0004148 xref: EHDAA2:0000238 xref: EHDAA:5051 xref: EMAPA:17215 xref: FMA:24138 xref: MA:0003154 xref: NCIT:C69313 xref: SCTID:260488005 xref: UMLS:C0728985 {source="ncithesaurus:Cervical_Spine"} is_a: UBERON:0006077 ! subdivision of vertebral column intersection_of: UBERON:0006077 ! subdivision of vertebral column intersection_of: subdivision_of UBERON:0005434 ! cervical region relationship: BFO:0000050 UBERON:0002090 ! part of postcranial axial skeleton relationship: BFO:0000050 UBERON:0012477 {source="FMA"} ! part of dorsal part of neck relationship: subdivision_of UBERON:0005434 ! cervical region property_value: skos:prefLabel "cervical region of vertebral column" xsd:string [Term] id: UBERON:0006073 name: thoracic region of vertebral column def: "That part of the spine comprising the thoracic vertebrae." [http://medical-dictionary.thefreedictionary.com/] subset: pheno_slim synonym: "axial skeleton thoracic region" EXACT [MA:0003155] synonym: "columna vertebralis thoracicus" EXACT [FMA:9140] synonym: "thoracic spine" EXACT [FMA:9140] synonym: "thoracic vertebrae series" EXACT [] synonym: "thoracic vertebral column" EXACT [FMA:9140] xref: BTO:0004150 xref: EHDAA:5063 xref: EMAPA:17396 xref: FMA:9140 xref: MA:0003155 xref: NCIT:C69315 xref: SCTID:243931006 xref: UMLS:C0581269 {source="ncithesaurus:Thoracic_Spine"} is_a: UBERON:0006077 ! subdivision of vertebral column intersection_of: UBERON:0006077 ! subdivision of vertebral column intersection_of: subdivision_of UBERON:0000915 ! thoracic segment of trunk relationship: BFO:0000050 UBERON:0008231 {source="FMA"} ! part of dorsal thoracic segment of trunk relationship: BFO:0000050 UBERON:0014477 ! part of thoracic skeleton relationship: subdivision_of UBERON:0000915 ! thoracic segment of trunk property_value: skos:prefLabel "thoracic region of vertebral column" xsd:string [Term] id: UBERON:0006074 name: lumbar region of vertebral column def: "Subdivision of vertebral column that corresponds to the lumbar subdivision of the body, containing the lumbar vertebrae." [UBERONREF:0000006] subset: pheno_slim synonym: "axial skeleton lumbar region" EXACT [MA:0003156] synonym: "lumbar skeleton" EXACT [EHDAA2:0001037] synonym: "lumbar spine" EXACT [BTO:0004147] synonym: "lumbar vertebrae series" EXACT [] synonym: "lumbar vertebral column" EXACT [FMA:16203] xref: BTO:0004147 xref: EHDAA2:0001037 xref: EHDAA:5055 xref: EMAPA:17393 xref: FMA:16203 xref: GAID:31 xref: MA:0003156 xref: NCIT:C69314 xref: SCTID:243932004 is_a: UBERON:0006077 ! subdivision of vertebral column intersection_of: UBERON:0006077 ! subdivision of vertebral column intersection_of: subdivision_of UBERON:0005462 ! lower back relationship: BFO:0000050 UBERON:0002090 ! part of postcranial axial skeleton relationship: BFO:0000050 UBERON:0005462 ! part of lower back relationship: subdivision_of UBERON:0005462 ! lower back [Term] id: UBERON:0006075 name: sacral region of vertebral column def: "Subdivision of vertebral column that corresponds to the sacral subdivision of the body, containing the sacral vertebrae or sacrum." [UBERONREF:0000006] synonym: "axial skeleton sacral region" EXACT [MA:0003157] synonym: "sacral skeleton" EXACT [EHDAA2:0001772] synonym: "sacral vertebrae series" EXACT [] synonym: "sacrum" NARROW [] xref: AAO:0000724 xref: EHDAA2:0001772 xref: EHDAA:5059 xref: EMAPA:17676 xref: GAID:32 xref: MA:0003157 xref: Wikipedia:Sacrum is_a: UBERON:0006077 ! subdivision of vertebral column intersection_of: UBERON:0006077 ! subdivision of vertebral column intersection_of: subdivision_of UBERON:0005473 ! sacral region relationship: BFO:0000050 UBERON:0002090 ! part of postcranial axial skeleton relationship: BFO:0000050 UBERON:0005473 ! part of sacral region relationship: subdivision_of UBERON:0005473 ! sacral region [Term] id: UBERON:0006076 name: caudal region of vertebral column def: "Subdivision of vertebral column that corresponds to the caudal subdivision of the body, containing the caudal vertebrae." [UBERONREF:0000006] synonym: "axial skeleton tail region" EXACT [MA:0003158] synonym: "caudal region" RELATED [AAO:0000082] synonym: "caudal skeleton" EXACT [UBERONREF:0000006] synonym: "caudal vertebrae series" EXACT [http://purl.bioontology.org/ontology/provisional/a047a2d5-418f-4d9c-ad21-ee0b7c29c29d] synonym: "postsacral region" RELATED [AAO:0000082] synonym: "tail region" RELATED [AAO:0000082] xref: AAO:0000082 xref: EMAPA:18043 xref: MA:0003158 is_a: UBERON:0006077 ! subdivision of vertebral column intersection_of: UBERON:0006077 ! subdivision of vertebral column intersection_of: subdivision_of UBERON:0006071 ! caudal region relationship: BFO:0000050 UBERON:0002090 ! part of postcranial axial skeleton relationship: BFO:0000050 UBERON:0006071 ! part of caudal region relationship: subdivision_of UBERON:0006071 ! caudal region property_value: skos:prefLabel "caudal region of vertebral column" xsd:string [Term] id: UBERON:0006077 name: subdivision of vertebral column def: "A collection of all skeletal elements in some subdivision of the vertebral column." [https://orcid.org/0000-0002-6601-2165] subset: non_informative synonym: "subdivision of vertebral skeleton" EXACT [https://orcid.org/0000-0002-6601-2165] synonym: "vertebrae series" EXACT [] synonym: "vertebral column subdivision" EXACT [FMA:16201] synonym: "vertebral region" RELATED [] synonym: "vertebral series" EXACT [] synonym: "vertebral subdivision" RELATED [] xref: FMA:16201 is_a: UBERON:0000075 ! subdivision of skeletal system intersection_of: UBERON:0000075 ! subdivision of skeletal system intersection_of: subdivision_of UBERON:0001130 ! vertebral column relationship: BFO:0000050 UBERON:0001130 ! part of vertebral column relationship: BFO:0000050 UBERON:0001137 {source="FMA"} ! part of dorsum relationship: subdivision_of UBERON:0001130 ! vertebral column property_value: skos:prefLabel "subdivision of vertebral column" xsd:string [Term] id: UBERON:0006082 name: fundus of urinary bladder def: "The base or posterior surface of the urinary bladder contains the trigone of the bladder and the outlet where urine empties through the internal urethral orifice." [MP:0011785, Wikipedia:Fundus_of_the_urinary_bladder#Fundus] subset: human_reference_atlas subset: pheno_slim synonym: "base of urinary bladder" EXACT [FMA:15908] synonym: "bladder dome" RELATED [EMAPA:35173] synonym: "fundus of bladder" BROAD [FMA:15908] synonym: "fundus vesicae" EXACT OMO:0003011 [FMA:15908, FMA:TA] synonym: "urinary bladder base" EXACT [MP:0011785] synonym: "urinary bladder fundus" EXACT [FMA:15908] synonym: "urinary bladder fundus region" EXACT [MA:0001694] xref: EHDAA2:0000582 xref: EHDAA:9330 xref: EMAPA:35173 xref: EMAPA_RETIRED:18322 xref: FMA:15908 xref: MA:0001694 xref: NCIT:C48939 xref: SCTID:362226002 xref: UMLS:C0447584 {source="ncithesaurus:Bladder_Fundus"} xref: VHOG:0001184 xref: Wikipedia:Fundus_of_the_urinary_bladder#Fundus is_a: BFO:0000002 is_a: UBERON:0000064 ! organ part relationship: BFO:0000050 UBERON:0001255 ! part of urinary bladder relationship: RO:0002202 UBERON:0005760 {source="EHDAA2-modified"} ! develops from urorectal septum relationship: RO:0002202 UBERON:0009845 {source="EHDAA2"} ! develops from urogenital sinus mesenchyme relationship: RO:0002433 UBERON:0001255 ! contributes to morphology of urinary bladder property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/urinary-bladder-female/v1.2/assets/3d-vh-f-urinary-bladder.glb" xsd:anyURI property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/urinary-bladder-male/v1.2/assets/3d-vh-m-urinary-bladder.glb" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0006098 name: basal nuclear complex def: "The deep nuclei of telencephalic origin found in the basal region of the forebrain." [BIRNLEX:1629] synonym: "basal ganglia" RELATED INCONSISTENT [BIRNLEX:1629] synonym: "basal ganglia (anatomic)" RELATED [NeuroNames:224] synonym: "basal nuclei" EXACT [BIRNLEX:1629] synonym: "basal nuclei of the forebrain" EXACT [BIRNLEX:1629] synonym: "corpus striatum (Savel'ev)" RELATED OMO:0003011 [NeuroNames:224] synonym: "ganglia basales" RELATED OMO:0003011 [NeuroNames:224] xref: BAMS:BG xref: BAMS:BNC xref: BIRNLEX:1629 xref: EV:0100182 xref: MESH:D001479 {sssom:mapping_justification="https://w3id.org/semapv/vocab/LexicalMatching"} xref: neuronames:224 {source="BIRNLEX:1629"} xref: UMLS:C0004781 {source="BIRNLEX:1629"} is_a: UBERON:0007245 ! nuclear complex of neuraxis is_a: UBERON:0019264 ! gray matter of forebrain relationship: BFO:0000050 UBERON:0002743 ! part of basal forebrain property_value: skos:prefLabel "basal nuclear complex" xsd:string [Term] id: UBERON:0006106 name: cochlear canal synonym: "cochlear canal" EXACT [BIRNLEX:2553] synonym: "spiral canal of cochlea" EXACT [BIRNLEX:2553] synonym: "spiral vessel" RELATED [MA:0003176] synonym: "wall of cochlea" EXACT [FMA:75371] xref: BIRNLEX:2553 xref: EMAPA:35801 xref: FMA:75371 xref: MA:0003176 xref: SCTID:279779009 xref: UMLS:C0009198 {source="BIRNLEX:2553"} xref: UMLS:C0458767 {source="BIRNLEX:2553"} is_a: UBERON:0005913 ! zone of bone organ relationship: BFO:0000050 UBERON:0001844 ! part of cochlea [Term] id: UBERON:0006107 name: basolateral amygdaloid nuclear complex def: "A set of amygdalar nuclei comprising the lateral nucleus (LA), the basal nucleus (BA), and the accessory basal nuclei (ABN). These nuclei are bordered laterally by the external capsule and medially by the central amygdalar nucleus as well as the amygdalohippocampal area. This definition refers to the rat Basolateral nuclear complex." [BIRNLEX:2679] subset: human_reference_atlas synonym: "amygdalar basolateral nucleus" EXACT [BIRNLEX:2679] synonym: "amygdaloid basolateral complex" EXACT [BIRNLEX:2679, FMA:84016] synonym: "basolateral amygdala" EXACT [Wikipedia:Basolateral_amygdala] synonym: "basolateral amygdaloid nuclear complex" EXACT [BIRNLEX:2679] synonym: "basolateral complex" RELATED [Wikipedia:Basolateral_amygdala] synonym: "basolateral nuclear complex" EXACT [BIRNLEX:2679] synonym: "basolateral nuclear group" EXACT [BIRNLEX:2679, FMA:84016] synonym: "basolateral nuclei of amygdala" EXACT [FMA:84016] synonym: "basolateral subdivision of amygdala" EXACT [FMA:84609] synonym: "BL" EXACT OMO:0003000 [BIRNLEX:2679] synonym: "pars basolateralis (Corpus amygdaloideum)" EXACT [BIRNLEX:2679] synonym: "set of basolateral nuclei of amygdala" RELATED [FMA:84016] synonym: "vicarious cortex" EXACT [BIRNLEX:2679, FMA:84016] xref: BAMS:ABL xref: BAMS:BL xref: BAMS:BLA xref: BIRNLEX:2679 xref: DHBA:10366 xref: FMA:84609 xref: neuronames:244 {source="BIRNLEX:2679"} xref: PBA:128012678 xref: UMLS:C0175220 {source="BIRNLEX:2679"} xref: Wikipedia:Basolateral_amygdala is_a: UBERON:0005401 ! cerebral hemisphere gray matter is_a: UBERON:0007245 ! nuclear complex of neuraxis relationship: BFO:0000050 UBERON:0001876 ! part of amygdala property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "basolateral amygdaloid nuclear complex" xsd:string [Term] id: UBERON:0006108 name: corticomedial nuclear complex def: "These structures are referred to as nuclei but have a layered cortical like structure. These areas include the anterior amygdaloid area, posterior amygdaloid area, the periamygdaloid cortex, and the bed nucleus of the accessory olfactory tract." [BIRNLEX:2680] synonym: "amygdalar corticomedial nucleus" EXACT [BIRNLEX:2680] synonym: "CMA" EXACT [BIRNLEX:2680] synonym: "corpus amygdaloideum pars corticomedialis" RELATED OMO:0003011 [NeuroNames:238] synonym: "corpus amygdaloideum pars olfactoria" RELATED OMO:0003011 [NeuroNames:238] synonym: "corticomedial nuclear complex" EXACT [BIRNLEX:2680] synonym: "corticomedial nuclear group" EXACT [BIRNLEX:2680, FMA:84015] synonym: "corticomedial nuclei of amygdala" EXACT [FMA:84015] synonym: "pars corticomedialis (Corpus amygdaloideum)" EXACT [BIRNLEX:2680] synonym: "set of corticomedial nuclei of amygdala" EXACT [FMA:84015] xref: BAMS:CMA xref: BIRNLEX:2680 xref: DHBA:10372 xref: FMA:84015 xref: neuronames:238 {source="BIRNLEX:2680"} xref: UMLS:C0175214 {source="BIRNLEX:2680"} is_a: UBERON:0005401 ! cerebral hemisphere gray matter is_a: UBERON:0007245 ! nuclear complex of neuraxis relationship: BFO:0000050 UBERON:0001876 ! part of amygdala property_value: skos:prefLabel "corticomedial nuclear complex" xsd:string [Term] id: UBERON:0006127 name: funiculus of spinal cord def: "A funiculus of neuraxis that is part of a spinal cord." [OBOL:automatic] synonym: "spinal cord funiculus" EXACT [FMA:77460] synonym: "white column of spinal cord" EXACT [FMA:77460] xref: FMA:77460 xref: neuronames:2760 is_a: UBERON:0006133 ! funiculus of neuraxis intersection_of: UBERON:0006133 ! funiculus of neuraxis intersection_of: BFO:0000050 UBERON:0002240 ! part of spinal cord relationship: BFO:0000050 UBERON:0002318 ! part of white matter of spinal cord property_value: skos:prefLabel "funiculus of spinal cord" xsd:string [Term] id: UBERON:0006133 name: funiculus of neuraxis def: "The cerebrospinal nerves consist of numerous nerve fibers collected together and enclosed in membranous sheaths. A small bundle of fibers, enclosed in a tubular sheath, is called a funiculus; if the nerve is of small size, it may consist only of a single funiculus; but if large, the funiculi are collected together into larger bundles or fasciculi, which are bound together in a common membranous investment. Examples include: Anterior funiculus of the spinal cord Lateral funiculus of the spinal cord Posterior funiculus of the spinal cord Funiculus solitarius of the medulla Funiculus separans." [Wikipedia:Funiculus_(neurology)] xref: FMA:76738 xref: Wikipedia:Funiculus_(neurology) is_a: UBERON:0000122 ! neuron projection bundle is_a: UBERON:0011215 ! central nervous system cell part cluster relationship: BFO:0000050 UBERON:0002316 ! part of white matter property_value: skos:prefLabel "funiculus of neuraxis" xsd:string [Term] id: UBERON:0006134 name: nerve fiber def: "A threadlike extension of a nerve cell and consists of an axon and myelin sheath (if it is myelinated) in the nervous system. There are nerve fibers in the central nervous system and peripheral nervous system. A nerve fiber may be myelinated and/or unmyelinated. In the central nervous system (CNS), myelin by oligodendroglia cells is formed. Schwann cells form myelin in the peripheral nervous system (PNS). Schwann cells also make a thin covering in an axon without myelin (in the PNS). A peripheral nerve fiber contains an axon, myelin sheath, schwann cells and its endoneurium. There are no endoneurium and schwann cells in the central nervous system." [Wikipedia:Nervous_system_fiber] subset: human_reference_atlas synonym: "nerve fibers" RELATED OMO:0003004 [BAMS:nfi] synonym: "nerve fibre" EXACT [FMA:5914] synonym: "neurofibra" EXACT OMO:0003011 [FMA:5914, FMA:TA] synonym: "neurofibra" RELATED OMO:0003011 [Wikipedia:Nerve_fiber] synonym: "neurofibrum" EXACT [FMA:5914] xref: BAMS:nfi xref: FMA:5914 xref: MESH:D009412 xref: SCTID:88545005 xref: Wikipedia:Nervous_system_fiber is_a: UBERON:0005162 ! multi cell part structure union_of: UBERON:0006135 ! myelinated nerve fiber union_of: UBERON:0006136 ! unmyelinated nerve fiber relationship: BFO:0000050 UBERON:0001019 ! part of nerve fasciculus relationship: BFO:0000051 GO:0030424 ! has part axon relationship: extends_fibers_into CL:0000540 ! neuron property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "nerve fiber" xsd:string [Term] id: UBERON:0006135 name: myelinated nerve fiber def: "Axons of neurons encased in a lipoproteinaceous material called myelin. (MeSH)." [ncithesaurus:Myelinated_Nerve_Fiber] subset: pheno_slim xref: FMA:5915 xref: GAID:745 xref: MESH:D009413 xref: NCIT:C12627 xref: SCTID:362296008 xref: UMLS:C0027750 {source="ncithesaurus:Myelinated_Nerve_Fiber"} is_a: UBERON:0006134 ! nerve fiber intersection_of: UBERON:0006134 ! nerve fiber intersection_of: BFO:0000051 GO:0043209 ! has part myelin sheath disjoint_from: UBERON:0006136 ! unmyelinated nerve fiber relationship: BFO:0000051 GO:0043209 ! has part myelin sheath relationship: RO:0002162 NCBITaxon:33213 ! in taxon Bilateria property_value: IAO:0000116 "consider adding link to UBERON:0002316 ! white matter of neuraxis" xsd:string property_value: RO:0002161 NCBITaxon:117569 property_value: RO:0002161 NCBITaxon:7762 property_value: RO:0002175 NCBITaxon:7776 property_value: skos:prefLabel "myelinated nerve fiber" xsd:string [Term] id: UBERON:0006136 name: unmyelinated nerve fiber subset: human_reference_atlas synonym: "non-myelinated nerve fiber" EXACT [FMA:5916] xref: FMA:5916 xref: GAID:767 xref: MESH:D036421 xref: NCIT:C33835 xref: SCTID:46920005 xref: UMLS:C0501409 {source="ncithesaurus:Unmyelinated_Nerve_Fiber"} is_a: UBERON:0006134 ! nerve fiber property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "unmyelinated nerve fiber" xsd:string [Term] id: UBERON:0006170 name: mesonephric capsule def: "The mesonephric capsule is the tough fibrous layer surrounding the mesonephros, covered in a thick layer of perinephric adipose tissue." [DOI:10.1371/journal.pone.0099864, GO:0061285, GOC:mtg_kidney_jan10] is_a: UBERON:0002015 ! kidney capsule intersection_of: UBERON:0002015 ! kidney capsule intersection_of: BFO:0000050 UBERON:0000080 ! part of mesonephros relationship: BFO:0000050 UBERON:0000080 ! part of mesonephros [Term] id: UBERON:0006173 name: pronephric proximal tubule synonym: "pronephros proximal tubule" EXACT [GO:0039011] is_a: UBERON:0004134 ! proximal tubule is_a: UBERON:0005310 ! pronephric nephron tubule intersection_of: UBERON:0004134 ! proximal tubule intersection_of: BFO:0000050 UBERON:0002120 ! part of pronephros [Term] id: UBERON:0006175 name: pronephric distal tubule is_a: UBERON:0004135 ! distal tubule is_a: UBERON:0005310 ! pronephric nephron tubule intersection_of: UBERON:0004135 ! distal tubule intersection_of: BFO:0000050 UBERON:0002120 ! part of pronephros [Term] id: UBERON:0006182 name: mesonephric glomerular mesangium def: "The mesonephric glomerular mesangium is the thin membrane connective tissue composed of mesangial cells in the mesonephros, which helps to support the capillary loops in a renal glomerulus." [GO:0061247] is_a: UBERON:0002320 ! glomerular mesangium intersection_of: UBERON:0002320 ! glomerular mesangium intersection_of: BFO:0000050 UBERON:0000080 ! part of mesonephros relationship: BFO:0000050 UBERON:0005326 {is_inferred="true", source="https://github.com/obophenotype/uberon/wiki/Inferring-part-of-relationships"} ! part of mesonephric glomerulus vasculature [Term] id: UBERON:0006183 name: mesonephric glomerular capillary def: "Missing definition for term UBERON:0006183. Please replace it using linked reference." [GO:0061249] is_a: UBERON:0004212 ! glomerular capillary intersection_of: UBERON:0004212 ! glomerular capillary intersection_of: BFO:0000050 UBERON:0000080 ! part of mesonephros relationship: BFO:0000050 UBERON:0005322 {source="https://github.com/obophenotype/uberon/wiki/Inferring-part-of-relationships"} ! part of mesonephric nephron relationship: BFO:0000050 UBERON:0005325 {is_inferred="true", source="https://github.com/obophenotype/uberon/wiki/Inferring-part-of-relationships"} ! part of mesonephric glomerulus [Term] id: UBERON:0006189 name: mesonephric connecting tubule def: "The mesonephric connecting tubule is a tubular segment of the mesonephric nephron; it connects the distal tubule to the collecting duct in the mesonephros." [GO:0061272] is_a: UBERON:0000083 ! mesonephric tubule is_a: UBERON:0005097 ! renal connecting tubule is_a: UBERON:0005330 ! mesonephric nephron epithelium intersection_of: UBERON:0005097 ! renal connecting tubule intersection_of: BFO:0000050 UBERON:0000080 ! part of mesonephros [Term] id: UBERON:0006190 name: mesonephric distal tubule def: "The mesonephric distal tubule is a mesonephric nephron tubule that begins at the macula densa and extends to the mesonephric connecting tubule." [GO:0061273] is_a: UBERON:0000083 ! mesonephric tubule is_a: UBERON:0004135 ! distal tubule is_a: UBERON:0005330 ! mesonephric nephron epithelium intersection_of: UBERON:0004135 ! distal tubule intersection_of: BFO:0000050 UBERON:0000080 ! part of mesonephros [Term] id: UBERON:0006192 name: mesonephric proximal tubule def: "The mesonephric proximal tubule extends from the capsule to the distal tubule." [GO:0061275] is_a: UBERON:0000083 ! mesonephric tubule is_a: UBERON:0004134 ! proximal tubule is_a: UBERON:0005330 ! mesonephric nephron epithelium intersection_of: UBERON:0004134 ! proximal tubule intersection_of: BFO:0000050 UBERON:0000080 ! part of mesonephros [Term] id: UBERON:0006206 name: iridocorneal angle def: "Acute angle occurring between the iris and the cornea at the periphery of the anterior chamber of the eye[MP]." [MP:0004221] subset: pheno_slim synonym: "anterior chamber angle" EXACT [FMA:58577] xref: FMA:58577 xref: SCTID:244498000 is_a: BFO:0000004 is_a: UBERON:0000015 ! non-material anatomical boundary relationship: BFO:0000050 UBERON:0003956 ! part of aqueous drainage system [Term] id: UBERON:0006207 name: aortico-pulmonary spiral septum def: "The spiral septum that separates the truncus arteriosus into a ventral pulmonary trunk and the dorsal aorta[MP]. The aorticopulmonary septum is developmentally formed from neural crest, specifically the cardiac neural crest, and actively separates the aorta and pulmonary arteries and fuses with the interventricular septum within the heart during development. The actual mechanism of septation of the outflow tract is poorly understood, but is recognized as a dynamic process with contributions from contractile, hemodynamic, and extracellular matrix interactions." [MP:0010650, Wikipedia:Aorticopulmonary_septum] subset: emapa_ehdaa2 subset: pheno_slim synonym: "aortic septum" RELATED [Wikipedia:Aorticopulmonary_septum] synonym: "aortico-pulmonary septum" EXACT [Wikipedia:Aorticopulmonary_septum] synonym: "aorticopulmonary septum" EXACT [Wikipedia:Aorticopulmonary_septum] synonym: "septum aorticopulmonale" EXACT OMO:0003011 [Wikipedia:Aorticopulmonary_septum] synonym: "spiral septum" RELATED [Wikipedia:Aorticopulmonary_septum] xref: CALOHA:TS-2409 xref: EHDAA2:0000136 xref: EHDAA:2592 xref: EMAPA:16827 xref: VHOG:0000502 xref: Wikipedia:Aorticopulmonary_septum is_a: BFO:0000002 is_a: UBERON:0004142 ! outflow tract septum intersection_of: UBERON:0002099 ! cardiac septum intersection_of: RO:0002220 UBERON:0002333 ! adjacent to pulmonary trunk intersection_of: RO:0002220 UBERON:0005805 ! adjacent to dorsal aorta relationship: RO:0002202 UBERON:0000095 {source="PMID:6844926", source="Wikipedia"} ! develops from cardiac neural crest relationship: RO:0002220 UBERON:0002333 ! adjacent to pulmonary trunk relationship: RO:0002220 UBERON:0005805 ! adjacent to dorsal aorta property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/b/b9/Gray470.png" xsd:anyURI property_value: skos:prefLabel "aortico-pulmonary spiral septum" xsd:string [Term] id: UBERON:0006208 name: auditory hillocks def: "A collection of protruberances derived from pharyngeal arches 1 and 2 that develop into the folds of the pinna and gradually shift upwards and backwards to their final position on the head." [Wikipedia:Pinna_(anatomy)#Development] subset: emapa_ehdaa2 synonym: "auditory hillock of Hiss" EXACT [] synonym: "auditory tubercles" RELATED INCONSISTENT [VHOG:0001364] synonym: "auricular hillock" RELATED [] synonym: "hillock of Hiss" RELATED [] xref: EHDAA2:0000155 xref: EHDAA:4685 xref: EMAPA:17280 xref: NCIT:C34110 xref: VHOG:0001364 is_a: BFO:0000004 is_a: UBERON:0000477 ! anatomical cluster relationship: BFO:0000050 UBERON:0000922 ! part of embryo relationship: BFO:0000050 UBERON:0001691 ! part of external ear [Term] id: UBERON:0006210 name: body-wall mesenchyme subset: emapa_ehdaa2 xref: EHDAA2:0000179 xref: EHDAA:3217 xref: EMAPA:16893 is_a: UBERON:0003104 ! mesenchyme relationship: BFO:0000050 UBERON:0000309 ! part of body wall [Term] id: UBERON:0006211 name: buccopharyngeal membrane def: "The thin bilaminar membrane derived from the prechordal plate that is devoid of mesoderm and formed by the apposition of the stomodeal ectoderm with the foregut endoderm; after the embryonic head fold has evolved it lies at the caudal limit of the stomodeum, forming a septum between the primitive mouth and pharynx; the membrane eventually disappears, and thus a communication is established between the mouth and the future pharynx." [MP:0012521] subset: emapa_ehdaa2 subset: pheno_slim synonym: "oral membrane" RELATED [MP:0012521] synonym: "oral plate" RELATED [MP:0012521] synonym: "oropharyngeal membrane" RELATED [Wikipedia:Buccopharyngeal_membrane] synonym: "pharyngeal membrane" RELATED INCONSISTENT [MP:0012521] xref: EHDAA2:0000189 xref: EHDAA:536 xref: EMAPA:16259 xref: FMA:313607 xref: SCTID:361412007 xref: VHOG:0000380 xref: Wikipedia:Buccopharyngeal_membrane is_a: BFO:0000002 is_a: UBERON:0003037 ! septum relationship: BFO:0000050 UBERON:0000922 ! part of embryo relationship: BFO:0000050 UBERON:0006264 {source="EHDAA2"} ! part of mouth-foregut junction relationship: RO:0002131 UBERON:0000930 ! overlaps stomodeum relationship: RO:0002131 UBERON:0001042 ! overlaps chordate pharynx relationship: RO:0002254 UBERON:0000924 ! has developmental contribution from ectoderm relationship: RO:0002254 UBERON:0000925 ! has developmental contribution from endoderm property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/9/93/Gray977.png" xsd:anyURI property_value: skos:prefLabel "buccopharyngeal membrane" xsd:string [Term] id: UBERON:0006213 name: carpus cartilage element def: "A cartilaginous condensation that has the potential to develop into a carpal bone." [OBOL:automatic] synonym: "carpal cartilage condensation" RELATED [EMAPA:18102] xref: EHDAA2:0000221 xref: EHDAA:8544 xref: EMAPA:18102 xref: VHOG:0001123 is_a: UBERON:0003319 ! mesenchyme of carpal region is_a: UBERON:0005863 ! cartilaginous condensation is_a: UBERON:0006598 ! presumptive structure is_a: UBERON:0010377 ! mesenchyme from somatopleure is_a: UBERON:0015049 ! carpus endochondral element intersection_of: UBERON:0005863 ! cartilaginous condensation intersection_of: RO:0002387 UBERON:0001435 ! has potential to develop into carpal bone relationship: RO:0002202 UBERON:0006214 ! develops from carpus pre-cartilage condensation relationship: RO:0002387 UBERON:0001435 ! has potential to develop into carpal bone [Term] id: UBERON:0006214 name: carpus pre-cartilage condensation def: "A pre-cartilage condensation that has the potential to develop into a carpal bone." [OBOL:automatic] synonym: "carpal pre-cartilage condensation" RELATED [EMAPA:17724] xref: EHDAA2:0000222 xref: EHDAA:6324 xref: EMAPA:17724 xref: VHOG:0000955 is_a: UBERON:0003319 ! mesenchyme of carpal region is_a: UBERON:0005866 ! pre-cartilage condensation is_a: UBERON:0006598 ! presumptive structure is_a: UBERON:0009523 ! mesenchyme of handplate is_a: UBERON:0015049 ! carpus endochondral element intersection_of: UBERON:0005866 ! pre-cartilage condensation intersection_of: RO:0002387 UBERON:0001435 ! has potential to develop into carpal bone relationship: BFO:0000050 UBERON:0009523 ! part of mesenchyme of handplate relationship: RO:0002202 UBERON:0003319 ! develops from mesenchyme of carpal region relationship: RO:0002387 UBERON:0001435 ! has potential to develop into carpal bone [Term] id: UBERON:0006215 name: rhombic lip def: "The posterior section of the developing metencephalon recognized transiently within the vertebrate embryo; the rhombic lip extends posteriorly from the roof of the fourth ventricle to dorsal neuroepithelial cell and can be divided into eight structural units based on rhombomeres 1-8 (r1-r8), recognized at early stages of hindbrain development; producing granule cells and five brainstem nuclei, the rhombic lip plays an important role in developing a complex cerebellar neural system." [MGI:anna, MP:0012525] subset: pheno_slim subset: vertebrate_core synonym: "cerebellar anlage" RELATED [MGI:anna] synonym: "cerebellar primordium" RELATED [EMAPA:17074] synonym: "cerebellum primordium" RELATED [EHDAA2:0000231, EMAPA:17074] synonym: "dorsal part of alar plate of metencephalon" RELATED [EMAPA:17074] synonym: "future cerebellum" RELATED [http://orcid.org/0000-0002-6601-2165] synonym: "presumptive cerebellum" RELATED [MGI:anna] synonym: "rostral rhombic lip" RELATED [MGI:anna] xref: DHBA:10664 xref: EHDAA2:0000231 xref: EMAPA:17074 xref: TAO:0001440 xref: Wikipedia:Rhombic_lips xref: XAO:0004135 xref: ZFA:0001440 is_a: UBERON:0001048 ! primordium is_a: UBERON:0006598 ! presumptive structure intersection_of: UBERON:0001048 ! primordium intersection_of: RO:0002387 UBERON:0002037 ! has potential to develop into cerebellum relationship: BFO:0000050 UBERON:0010092 {source="EHDAA2", source="Wikipedia"} ! part of future metencephalon relationship: RO:0002387 UBERON:0002037 ! has potential to develop into cerebellum property_value: skos:prefLabel "rhombic lip" xsd:string [Term] id: UBERON:0006217 name: cloacal membrane def: "The membrane that covers the embryonic cloaca, formed by the union of proctodeal (anal pit) ectoderm and cloacal endoderm, with no intervening mesoderm; the urorectal septum joins the cloacal membrane and divides it into an anal membrane and a urogenital membrane; the point where the urorectal septum intersects the cloacal membrane is the future site of the perineal body; proliferation of mesoderm and ectoderm around the cloacal membrane produces primordial tissues of the external genitalia in both sexes: the genital tubercle, genital folds, and genital swellings." [MP:0011837, MP:anna, Wikipedia:Cloacal_membrane] subset: emapa_ehdaa2 subset: pheno_slim synonym: "embryonic cloacal membrane" EXACT [] synonym: "membrana cloacalis" RELATED OMO:0003011 [Wikipedia:Cloacal_membrane] xref: EHDAA2:0000257 xref: EHDAA:214 xref: EHDAA:2933 xref: EMAPA:16832 xref: FMA:295525 xref: NCIT:C34128 xref: SCTID:308826008 xref: UMLS:C0231056 {source="ncithesaurus:Cloacal_Membrane"} xref: VHOG:0001198 xref: Wikipedia:Cloacal_membrane is_a: BFO:0000002 is_a: UBERON:0000158 ! membranous layer relationship: BFO:0000050 UBERON:0000163 ! part of embryonic cloaca relationship: RO:0002202 UBERON:0004341 {source="Wikipedia"} ! develops from primitive streak relationship: RO:0002254 UBERON:0000924 ! has developmental contribution from ectoderm relationship: RO:0002254 UBERON:0000925 ! has developmental contribution from endoderm relationship: RO:0002433 UBERON:0000163 ! contributes to morphology of embryonic cloaca property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/d/d2/Gray991.png" xsd:anyURI [Term] id: UBERON:0006218 name: common atrial chamber subset: emapa_ehdaa2 xref: EHDAA:1267 xref: EMAPA:16342 xref: RETIRED_EHDAA2:0000268 is_a: UBERON:0002050 ! embryonic structure relationship: BFO:0000050 UBERON:0002081 ! part of cardiac atrium property_value: skos:prefLabel "common atrial chamber" xsd:string [Term] id: UBERON:0006219 name: deltoid pre-muscle mass subset: emapa_ehdaa2 xref: EHDAA2:0000340 xref: EHDAA:6002 xref: EMAPA:17749 is_a: UBERON:0005865 {source="EHDAA2"} ! pre-muscle condensation relationship: BFO:0000050 UBERON:0008713 {source="EHDAA2"} ! part of pectoral girdle and thoracic body wall skeletal muscle relationship: RO:0002202 UBERON:0010963 {source="EHDAA2"} ! develops from trunk and cervical myotome group [Term] id: UBERON:0006222 name: future diencephalon def: "The foremost region of the future forebrain that develops into the diencephalon." [UBERON:cjm, Wikipedia:Diencephalon] subset: efo_slim subset: emapa_ehdaa2 subset: vertebrate_core synonym: "presumptive diencephalon" EXACT [TAO:0000574] xref: EFO:0003442 xref: EHDAA2:0000600 xref: EHDAA:844 xref: EMAPA:16514 xref: RETIRED_EHDAA2:0000386 xref: TAO:0000574 xref: ZFA:0000574 is_a: UBERON:0006598 ! presumptive structure intersection_of: UBERON:0006598 ! presumptive structure intersection_of: RO:0002387 UBERON:0001894 ! has potential to develop into diencephalon relationship: BFO:0000050 UBERON:0006240 {source="EHDAA2"} ! part of future forebrain relationship: RO:0002387 UBERON:0001894 ! has potential to develop into diencephalon property_value: skos:prefLabel "future diencephalon" xsd:string [Term] id: UBERON:0006224 name: elbow joint primordium subset: emapa_ehdaa2 xref: EHDAA2:0000431 xref: EHDAA:8483 xref: EMAPA:17710 is_a: UBERON:0001048 ! primordium relationship: BFO:0000050 UBERON:0003318 ! part of mesenchyme of elbow relationship: RO:0002387 UBERON:0001490 ! has potential to develop into elbow joint [Term] id: UBERON:0006227 name: ethmoid bone primordium subset: emapa_ehdaa2 xref: EHDAA2:0000456 xref: EHDAA:8363 xref: EMAPA:18023 xref: FMA:312597 is_a: BFO:0000002 is_a: UBERON:0001048 ! primordium intersection_of: UBERON:0001048 ! primordium intersection_of: RO:0002387 UBERON:0001679 ! has potential to develop into ethmoid bone relationship: BFO:0000050 UBERON:0002517 {source="FMA"} ! part of basicranium relationship: BFO:0000050 UBERON:0011241 {source="AAO"} ! part of ethmoid region relationship: RO:0002202 UBERON:0007213 {source="EHDAA2"} ! develops from mesenchyme derived from head neural crest relationship: RO:0002387 UBERON:0001679 ! has potential to develop into ethmoid bone property_value: IAO:0000116 "consider obsoleting, the ethmoid is endochondral?" xsd:string property_value: skos:prefLabel "ethmoid bone primordium" xsd:string [Term] id: UBERON:0006230 name: extrinsic ocular pre-muscle mass subset: emapa_ehdaa2 xref: EHDAA2:0000483 xref: EHDAA:2925 xref: EMAPA:17845 is_a: UBERON:0003314 ! eye mesenchyme is_a: UBERON:0005865 ! pre-muscle condensation relationship: BFO:0000050 UBERON:0003269 {source="EHDAA2"} ! part of skeletal muscle tissue of eye relationship: RO:0002202 UBERON:0003314 {source="EHDAA2", source="ISBN:0781772214"} ! develops from eye mesenchyme property_value: skos:prefLabel "extrinsic ocular pre-muscle mass" xsd:string [Term] id: UBERON:0006232 name: facio-acoustic VII-VIII preganglion complex subset: emapa_ehdaa2 synonym: "facio-acoustic preganglion complex" RELATED [EMAPA:16660] xref: EHDAA:1477 xref: EMAPA:16660 xref: RETIRED_EHDAA2:0000496 is_a: BFO:0000002 is_a: UBERON:0002050 ! embryonic structure relationship: BFO:0000050 UBERON:0001714 {source="EHDAA2"} ! part of cranial ganglion relationship: RO:0002202 UBERON:0005565 ! develops from facio-acoustic neural crest property_value: skos:prefLabel "facio-acoustic VII-VIII preganglion complex" xsd:string [Term] id: UBERON:0006233 name: female genital tubercle def: "A differentiated genital tubercle that is part of a female reproductive system." [OBOL:automatic] subset: emapa_ehdaa2 synonym: "genital tubercle of female" EXACT [EMAPA:18680] xref: EHDAA:8118 xref: EMAPA:18680 xref: RETIRED_EHDAA2:0000500 xref: VHOG:0000666 is_a: UBERON:0011757 ! differentiated genital tubercle intersection_of: UBERON:0011757 ! differentiated genital tubercle intersection_of: BFO:0000050 UBERON:0000474 ! part of female reproductive system relationship: BFO:0000050 UBERON:0005056 {is_inferred="true", source="https://github.com/obophenotype/uberon/wiki/Inferring-part-of-relationships"} ! part of external female genitalia [Term] id: UBERON:0006234 name: femur pre-cartilage condensation def: "A femur endochondral element that is composed primarily of a pre-cartilage condensation." [OBOL:automatic] subset: emapa_ehdaa2 synonym: "femoral pre-cartilage condensation" RELATED [EMAPA:17502] xref: EHDAA2:0000508 xref: EMAPA:17502 xref: VHOG:0000951 is_a: UBERON:0005254 ! upper leg mesenchyme is_a: UBERON:0005866 ! pre-cartilage condensation is_a: UBERON:0010886 ! hindlimb pre-cartilage condensation is_a: UBERON:0015052 ! femur endochondral element intersection_of: UBERON:0015052 ! femur endochondral element intersection_of: RO:0002473 UBERON:0005866 ! composed primarily of pre-cartilage condensation relationship: RO:0002387 UBERON:0000981 ! has potential to develop into femur [Term] id: UBERON:0006235 name: foregut-midgut junction def: "An anatomical junctions that overlaps the foregut and midgut." [OBOL:automatic] subset: emapa_ehdaa2 xref: EHDAA2:0000569 xref: EHDAA:526 xref: EMAPA:16363 xref: VHOG:0000291 is_a: UBERON:1100000 ! digestive tract junction intersection_of: UBERON:0007651 ! anatomical junction intersection_of: RO:0002176 UBERON:0001041 ! connects foregut intersection_of: RO:0002176 UBERON:0001045 ! connects midgut relationship: BFO:0000050 UBERON:0001555 ! part of digestive tract relationship: RO:0002176 UBERON:0001041 ! connects foregut relationship: RO:0002176 UBERON:0001045 ! connects midgut property_value: skos:prefLabel "foregut-midgut junction" xsd:string [Term] id: UBERON:0006236 name: tetrapod frontal bone primordium subset: emapa_ehdaa2 synonym: "frontal bone primordium" EXACT [EHDAA2:0000577] xref: EHDAA2:0000577 xref: EHDAA:9540 xref: EMAPA:18017 xref: FMA:312589 is_a: UBERON:0001048 ! primordium intersection_of: UBERON:0001048 ! primordium intersection_of: RO:0002387 UBERON:0000209 ! has potential to develop into tetrapod frontal bone relationship: RO:0002387 UBERON:0000209 ! has potential to develop into tetrapod frontal bone property_value: skos:prefLabel "tetrapod frontal bone primordium" xsd:string [Term] id: UBERON:0006238 name: future brain def: "The embryonic precursor of the brain." [NLX:94995] subset: cumbo subset: efo_slim subset: emapa_ehdaa2 subset: vertebrate_core synonym: "brain rudiment" EXACT [TAO:0000146] synonym: "embryonic brain" RELATED [BTO:0004726] synonym: "encephalon" NARROW [NLX:94995] synonym: "presumptive brain" EXACT [ZFA:0000146] xref: BAMS:Enc xref: BTO:0004726 xref: EFO:0003431 xref: EHDAA:300 xref: EHDAA:830 xref: EMAPA:16089 xref: FMA:312967 xref: RETIRED_EHDAA2:0000591 xref: TAO:0000146 xref: ZFA:0000146 is_a: UBERON:0006598 ! presumptive structure relationship: BFO:0000050 UBERON:0002346 ! part of neurectoderm relationship: RO:0002387 UBERON:0000955 ! has potential to develop into brain property_value: skos:prefLabel "future brain" xsd:string [Term] id: UBERON:0006239 name: future central tendon def: "A tendon that has the potential to develop into a central tendon." [OBOL:automatic] subset: emapa_ehdaa2 synonym: "cranial derivative of septum transversum" RELATED [http://orcid.org/0000-0002-6601-2165] synonym: "cranial part of septum transversum" RELATED [http://orcid.org/0000-0002-6601-2165] xref: EHDAA2:0000593 xref: EHDAA:4118 xref: EMAPA:25035 is_a: UBERON:0000043 ! tendon is_a: UBERON:0005291 ! embryonic tissue is_a: UBERON:0006598 ! presumptive structure intersection_of: UBERON:0000043 ! tendon intersection_of: RO:0002387 UBERON:0006670 ! has potential to develop into central tendon of diaphragm relationship: BFO:0000050 UBERON:0010084 {source="EHDAA2"} ! part of future diaphragm relationship: RO:0002202 UBERON:0004161 ! develops from septum transversum relationship: RO:0002387 UBERON:0006670 ! has potential to develop into central tendon of diaphragm property_value: skos:prefLabel "future central tendon" xsd:string [Term] id: UBERON:0006240 name: future forebrain def: "A presumptive structure that has the potential to develop into a forebrain." [OBOL:automatic] subset: efo_slim subset: emapa_ehdaa2 subset: vertebrate_core synonym: "future prosencephalon" EXACT [] synonym: "presumptive forebrain" EXACT [ZFA:0000062] synonym: "presumptive prosencephalon" EXACT [TAO:0000062] synonym: "prosencephalon" RELATED [EHDAA2:0000661] xref: BAMS:Pros xref: EFO:0003423 xref: EHDAA2:0000661 xref: EHDAA:2643 xref: EMAPA:16640 xref: TAO:0000062 xref: Wikipedia:Prosencephalon xref: ZFA:0000062 is_a: UBERON:0006598 ! presumptive structure intersection_of: UBERON:0006598 ! presumptive structure intersection_of: RO:0002387 UBERON:0001890 ! has potential to develop into forebrain relationship: BFO:0000050 UBERON:0006238 ! part of future brain relationship: RO:0002387 UBERON:0001890 ! has potential to develop into forebrain property_value: IAO:0000116 "TODO. Add relationships to neural plate (both ZFA and EMAPA time this with the neural plate)" xsd:string property_value: skos:prefLabel "future forebrain" xsd:string [Term] id: UBERON:0006241 name: future spinal cord subset: efo_slim subset: vertebrate_core synonym: "presumptive spinal cord" EXACT [ZFA:0000417] synonym: "presumptive spinal cord neural keel" EXACT [TAO:0000417] synonym: "presumptive spinal cord neural plate" EXACT [TAO:0000417] synonym: "presumptive spinal cord neural rod" EXACT [TAO:0000417] xref: EFO:0003438 xref: EHDAA2:0000674 xref: EHDAA:898 xref: EMAPA:16092 xref: EMAPA:16755 xref: TAO:0000417 xref: ZFA:0000417 is_a: UBERON:0006598 ! presumptive structure relationship: BFO:0000050 UBERON:0001017 ! part of central nervous system relationship: RO:0002387 UBERON:0001049 {source="EHDAA2"} ! has potential to develop into neural tube relationship: RO:0002387 UBERON:0002240 ! has potential to develop into spinal cord property_value: skos:prefLabel "future spinal cord" xsd:string [Term] id: UBERON:0006242 name: gallbladder primordium def: "A sac-like cavity ventral to the liver, lying in the sub-mesodermal space and closed by a thin sheet of ectodermal cells, from which the future gall bladder develops." [ISBN:0815318960, XAO:0004205] subset: emapa_ehdaa2 synonym: "gall bladder primordium" EXACT [] xref: EHDAA2:0000700 xref: EHDAA:3047 xref: EMAPA:16713 xref: XAO:0004205 is_a: BFO:0000002 is_a: UBERON:0001048 ! primordium is_a: UBERON:0006598 ! presumptive structure intersection_of: UBERON:0001048 ! primordium intersection_of: RO:0002387 UBERON:0002110 ! has potential to develop into gallbladder relationship: BFO:0000050 UBERON:0004912 {source="EMAPA"} ! part of biliary bud relationship: RO:0002202 UBERON:0001152 {source="EHDAA2"} ! develops from cystic duct relationship: RO:0002387 UBERON:0002110 ! has potential to develop into gallbladder property_value: skos:prefLabel "gallbladder primordium" xsd:string [Term] id: UBERON:0006245 name: humerus cartilage element def: "A humerus endochondral element that is composed primarily of cartilage tissue." [OBOL:automatic] subset: emapa_ehdaa2 synonym: "humeral cartilage condensation" RELATED [EMAPA:17713] xref: EHDAA2:0000787 xref: EHDAA:6240 xref: EMAPA:17713 xref: VHOG:0001120 is_a: UBERON:0005258 ! upper arm mesenchyme is_a: UBERON:0005863 ! cartilaginous condensation is_a: UBERON:0010883 ! forelimb cartilage element is_a: UBERON:0015053 ! humerus endochondral element intersection_of: UBERON:0015053 ! humerus endochondral element intersection_of: RO:0002473 UBERON:0002418 ! composed primarily of cartilage tissue relationship: BFO:0000050 UBERON:0005258 {source="EHDAA2"} ! part of upper arm mesenchyme relationship: RO:0002202 UBERON:0006246 {source="EHDAA2"} ! develops from humerus pre-cartilage condensation relationship: RO:0002387 UBERON:0000976 ! has potential to develop into humerus [Term] id: UBERON:0006246 name: humerus pre-cartilage condensation def: "A humerus endochondral element that is composed primarily of a pre-cartilage condensation." [OBOL:automatic] subset: emapa_ehdaa2 synonym: "humeral pre-cartilage condensation" RELATED [EMAPA:17427] xref: EHDAA2:0000788 xref: EHDAA:4192 xref: EMAPA:17427 xref: VHOG:0000950 is_a: UBERON:0005258 ! upper arm mesenchyme is_a: UBERON:0005866 ! pre-cartilage condensation is_a: UBERON:0010884 ! forelimb bone pre-cartilage condensation is_a: UBERON:0015053 ! humerus endochondral element intersection_of: UBERON:0015053 ! humerus endochondral element intersection_of: RO:0002473 UBERON:0005866 ! composed primarily of pre-cartilage condensation relationship: BFO:0000050 UBERON:0005258 {source="EHDAA2"} ! part of upper arm mesenchyme relationship: RO:0002387 UBERON:0000976 ! has potential to develop into humerus [Term] id: UBERON:0006247 name: iliac pre-cartilage condensation def: "An iliac endochondral element that is composed primarily of a pre-cartilage condensation." [OBOL:automatic] subset: emapa_ehdaa2 xref: EHDAA2:0000809 xref: EHDAA:9568 xref: EMAPA:18029 xref: VHOG:0000964 is_a: UBERON:0005256 ! trunk mesenchyme is_a: UBERON:0005866 ! pre-cartilage condensation is_a: UBERON:0015054 ! iliac endochondral element intersection_of: UBERON:0015054 ! iliac endochondral element intersection_of: RO:0002473 UBERON:0005866 ! composed primarily of pre-cartilage condensation relationship: RO:0002202 UBERON:0006210 {source="EHDAA2"} ! develops from body-wall mesenchyme relationship: RO:0002473 UBERON:0005866 ! composed primarily of pre-cartilage condensation [Term] id: UBERON:0006250 name: infundibular recess of 3rd ventricle def: "A funnel-shaped diverticulum that extends downward from the anterior aspect of the floor of the third ventricle into the infundibulum of the hypophysis; the embryonic structure gives rise the neural component of the pituitary (pas nervosa)." [https://sourceforge.net/p/obo/mammalian-phenotype-requests/1930/, MGI:anna] subset: pheno_slim synonym: "infundibular reccess" RELATED [BAMS:IRe] synonym: "infundibular recess" EXACT [FMA:78456] synonym: "infundibular recess of third ventricle" EXACT [FMA:78456] synonym: "recessus infundibularis" EXACT OMO:0003011 [FMA:TA] synonym: "recessus infundibuli" EXACT OMO:0003011 [FMA:TA] synonym: "recessus infundibuli" RELATED OMO:0003011 [Wikipedia:Infundibular_recess] synonym: "third ventricle infundibular recess" RELATED [BAMS:V3ir] xref: BAMS:IRe xref: BAMS:V3ir xref: EHDAA2:0000827 xref: EHDAA:4479 xref: EMAPA:16899 xref: EMAPA_RETIRED:16648 xref: FMA:78456 xref: neuronames:458 xref: SCTID:369280006 xref: Wikipedia:Infundibular_recess is_a: BFO:0000002 is_a: UBERON:0002050 ! embryonic structure is_a: UBERON:0005291 ! embryonic tissue is_a: UBERON:0007499 {source="EHDAA2"} ! epithelial sac relationship: BFO:0000050 UBERON:0002286 {source="EMAPA"} ! part of third ventricle relationship: BFO:0000050 UBERON:0034876 {source="EMAPA"} ! part of future neurohypophysis relationship: RO:0002202 UBERON:0003309 {source="EHDAA2"} ! develops from floor plate of diencephalon relationship: RO:0002202 UBERON:0034876 {source="EHDAA2"} ! develops from future neurohypophysis property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/7/75/Gray654.png" xsd:anyURI property_value: IAO:0000116 "in FMA this is a cavity, whereas in EHDAA2 it is an epithelial sac" xsd:string [Term] id: UBERON:0006254 name: ischial cartilage element def: "An ischial endochondral element that is composed primarily of cartilage tissue." [OBOL:automatic] subset: emapa_ehdaa2 synonym: "ischial cartilage condensation" RELATED [EMAPA:26930] xref: EHDAA2:0000890 xref: EHDAA:9570 xref: EMAPA:26930 is_a: UBERON:0005863 {source="EHDAA2"} ! cartilaginous condensation is_a: UBERON:0007844 ! cartilage element is_a: UBERON:0015056 ! ischial endochondral element intersection_of: UBERON:0015056 ! ischial endochondral element intersection_of: RO:0002473 UBERON:0002418 ! composed primarily of cartilage tissue relationship: RO:0002202 UBERON:0006255 {source="EHDAA2"} ! develops from ischial pre-cartilage condensation [Term] id: UBERON:0006255 name: ischial pre-cartilage condensation def: "An ischial endochondral element that is composed primarily of a pre-cartilage condensation." [OBOL:automatic] subset: emapa_ehdaa2 xref: EHDAA2:0000891 xref: EHDAA:7153 xref: EMAPA:18348 xref: VHOG:0000962 is_a: UBERON:0005256 ! trunk mesenchyme is_a: UBERON:0005866 {source="EHDAA2"} ! pre-cartilage condensation is_a: UBERON:0015056 ! ischial endochondral element intersection_of: UBERON:0015056 ! ischial endochondral element intersection_of: RO:0002473 UBERON:0005866 ! composed primarily of pre-cartilage condensation relationship: RO:0002473 UBERON:0005866 ! composed primarily of pre-cartilage condensation [Term] id: UBERON:0006256 name: knee joint primordium subset: emapa_ehdaa2 xref: EHDAA2:0000897 xref: EHDAA:8467 xref: EMAPA:17740 is_a: UBERON:0001048 ! primordium is_a: UBERON:0006598 ! presumptive structure relationship: BFO:0000050 UBERON:0003321 ! part of mesenchyme of knee relationship: RO:0002387 UBERON:0001485 ! has potential to develop into knee joint [Term] id: UBERON:0006260 name: lingual swellings comment: the collection consisting of the two lateral swellings and the medial swelling subset: emapa_ehdaa2 synonym: "lingual swelling" RELATED [EHDAA2:0000996] xref: EHDAA2:0000996 xref: EMAPA:17186 xref: VHOG:0000449 is_a: BFO:0000002 is_a: UBERON:0002050 ! embryonic structure is_a: UBERON:0010188 {source="EHDAA2"} ! protuberance relationship: BFO:0000050 UBERON:0010056 {source="EHDAA2"} ! part of future tongue relationship: RO:0002202 UBERON:0004362 ! develops from pharyngeal arch 1 property_value: skos:prefLabel "lingual swellings" xsd:string [Term] id: UBERON:0006261 name: male genital tubercle def: "A differentiated genital tubercle that is part of a male reproductive system." [OBOL:automatic] subset: emapa_ehdaa2 synonym: "genital tubercle of male" EXACT [EMAPA:17969] synonym: "penis anlage" RELATED [EMAPA:17969] xref: EHDAA:8138 xref: EMAPA:17969 xref: RETIRED_EHDAA2:0001048 xref: VHOG:0000667 is_a: UBERON:0011757 ! differentiated genital tubercle intersection_of: UBERON:0011757 ! differentiated genital tubercle intersection_of: BFO:0000050 UBERON:0000079 ! part of male reproductive system relationship: BFO:0000050 UBERON:0004053 {is_inferred="true", source="https://github.com/obophenotype/uberon/wiki/Inferring-part-of-relationships"} ! part of external male genitalia [Term] id: UBERON:0006264 name: mouth-foregut junction def: "An anatomical junctions that overlaps the mouth and foregut." [OBOL:automatic] subset: emapa_ehdaa2 xref: EHDAA:534 xref: EMAPA:16258 xref: RETIRED_EHDAA2:0001205 xref: VHOG:0000592 is_a: UBERON:0007651 ! anatomical junction intersection_of: UBERON:0007651 ! anatomical junction intersection_of: RO:0002131 UBERON:0000165 ! overlaps mouth intersection_of: RO:0002131 UBERON:0001041 ! overlaps foregut relationship: BFO:0000050 UBERON:0001555 ! part of digestive tract relationship: RO:0002131 UBERON:0000165 ! overlaps mouth relationship: RO:0002131 UBERON:0001041 ! overlaps foregut property_value: skos:prefLabel "mouth-foregut junction" xsd:string [Term] id: UBERON:0006266 name: nasolacrimal groove def: "Groove between maxillary prominence and lateral nasal process." [http://www.indiana.edu/~anat550/hnanim/face/face.html, Wikipedia:Lacrimal_groove] comment: On the nasal surface of the body of the maxilla, in front of the opening of the sinus is a deep groove, the lacrimal groove (or lacrimal sulcus), which is converted into the nasolacrimal canal, by the lacrimal bone and inferior nasal concha; this canal opens into the inferior meatus of the nose and transmits the nasolacrimal duct[WP] See also: oblique facial cleft subset: emapa_ehdaa2 synonym: "naso-lacrimal groove" EXACT [EMAPA:16679] synonym: "s. lacrimalis maxillae" RELATED OMO:0003011 [Wikipedia:Lacrimal_groove] xref: EHDAA2:0001238 xref: EHDAA:4770 xref: EMAPA:16679 xref: FMA:300055 xref: NCIT:C34218 xref: UMLS:C1513875 {source="ncithesaurus:Nasolacrimal_Groove"} xref: VHOG:0001307 xref: Wikipedia:Lacrimal_groove is_a: BFO:0000002 is_a: UBERON:0000490 {source="EHDAA2"} ! unilaminar epithelium is_a: UBERON:0005291 ! embryonic tissue is_a: UBERON:0019306 ! nose epithelium relationship: BFO:0000050 UBERON:0000076 {source="EHDAA2"} ! part of external ectoderm relationship: RO:0002202 UBERON:0012313 {source="EHDAA2"} ! develops from 1st arch maxillary ectoderm relationship: RO:0002220 UBERON:0004067 ! adjacent to lateral nasal prominence relationship: RO:0002220 UBERON:0005868 ! adjacent to maxillary prominence property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/3/3f/Gray163.png" xsd:anyURI [Term] id: UBERON:0006267 name: notochordal plate def: "The notochordal plate is the dorsal part of the notochordal process when the ventral portion breaks down. It is continuous laterally with the endoderm that composes the roof of the primitive foregut and is in contact dorsally with the neural tube. The folding off of the notochordal plate gives rise to the notochord." [VHOG:0001212] subset: emapa_ehdaa2 xref: EHDAA2:0001278 xref: EHDAA:264 xref: EMAPA:16101 xref: NCIT:C34231 xref: UMLS:C1518429 {source="ncithesaurus:Notochordal_Plate"} xref: VHOG:0001212 is_a: UBERON:0000490 {source="EHDAA2"} ! unilaminar epithelium is_a: UBERON:0002050 ! embryonic structure is_a: UBERON:0005291 ! embryonic tissue is_a: UBERON:0010371 ! ecto-epithelium relationship: RO:0002202 UBERON:0006268 {source="EHDAA2"} ! develops from notochordal process property_value: IAO:0000116 "TODO - check ordering; awaiting confirmation from JB" xsd:string property_value: skos:prefLabel "notochordal plate" xsd:string [Term] id: UBERON:0006268 name: notochordal process def: "A midline cellular cord formed from the migration of mesenchymal cells from the primitive knot." [http://www.med.umich.edu/lrc/coursepages/m1/embryology/embryo/05embryonicperiod.htm] comment: The notochordal process grows cranially until it reaches the prechordal plate, the future site of the mouth. In this area the ectoderm is attached directly to the endoderm without intervening mesoderm. This area is known as the oropharyngeal membrane, and it will break down to become the mouth. At the other end of the primitive streak the ectoderm is also fused directly to the endoderm; this is known as the cloacal membrane (proctodeum), or primordial anus. subset: emapa_ehdaa2 synonym: "chordamesoderm" RELATED [] synonym: "presumptive notochord" RELATED [] xref: EHDAA2:0001279 xref: EHDAA:224 xref: EMAPA:16102 xref: FMA:293135 xref: NCIT:C34232 xref: UMLS:C1518430 {source="ncithesaurus:Notochordal_Process"} xref: VHOG:0001213 is_a: BFO:0000002 is_a: UBERON:0005423 ! developing anatomical structure relationship: RO:0002162 NCBITaxon:7711 ! in taxon Chordata relationship: RO:0002202 UBERON:0000924 {source="EHDAA2"} ! develops from ectoderm property_value: skos:prefLabel "notochordal process" xsd:string [Term] id: UBERON:0006271 name: orbital fissure def: "Either of two openings transmitting nerves and blood vessels to or from the orbit." [http://www.merriam-webster.com/medical/orbital%20fissure] subset: emapa_ehdaa2 xref: EHDAA2:0001328 xref: EHDAA:10648 xref: EMAPA:18717 xref: SCTID:280546005 is_a: UBERON:0013685 ! foramen of skull intersection_of: UBERON:0013685 ! foramen of skull intersection_of: BFO:0000050 UBERON:0001697 ! part of orbit of skull relationship: BFO:0000050 UBERON:0001697 ! part of orbit of skull property_value: skos:prefLabel "orbital fissure" xsd:string [Term] id: UBERON:0006273 name: otic pit def: "The pair of depressions of thickened otic placode epithelium, that further develops into the otic vesicles." [ISBN:0-683-40008-8, MP:0011172] subset: emapa_ehdaa2 subset: pheno_slim synonym: "otic cup" EXACT [NCBIBook:NBK53175] xref: EHDAA2:0001336 xref: EHDAA:929 xref: EMAPA:16536 xref: FMA:302911 xref: NCIT:C34238 xref: VHOG:0001147 xref: Wikipedia:Otic_pit is_a: UBERON:0016566 {source="EHDAA2"} ! pit relationship: BFO:0000050 UBERON:0003069 ! part of otic placode relationship: RO:0002387 UBERON:0003051 ! has potential to develop into ear vesicle property_value: skos:prefLabel "otic pit" xsd:string [Term] id: UBERON:0006279 name: pleuroperitoneal canal def: "Each of the canals that links the peritoneal cavity and the caudal part of a pleural cavity." [ISBN:0124020607, VHOG:0001505] subset: emapa_ehdaa2 synonym: "pleuroperitoneal channel" RELATED [VHOG:0001505] xref: EHDAA2:0001481 xref: EHDAA:4128 xref: EMAPA:17707 xref: SCTID:361413002 xref: VHOG:0001505 is_a: UBERON:0003914 {source="EHDAA2"} ! epithelial tube is_a: UBERON:0005291 ! embryonic tissue intersection_of: UBERON:0003914 ! epithelial tube intersection_of: RO:0002176 UBERON:0001179 ! connects peritoneal cavity intersection_of: RO:0002176 UBERON:0002402 ! connects pleural cavity relationship: BFO:0000050 UBERON:0011997 {source="EHDAA2"} ! part of coelom relationship: RO:0002176 UBERON:0001179 ! connects peritoneal cavity relationship: RO:0002176 UBERON:0002402 ! connects pleural cavity property_value: skos:prefLabel "pleuroperitoneal canal" xsd:string [Term] id: UBERON:0006283 name: future cardiac ventricle def: "Multi-tissue structure that is part of the heart tube and will become the cardiac ventricle." [ZFA:0001719] comment: The embryonic ventricle or primitive ventricle of the developing heart gives rise to the trabeculated parts of the left and right ventricles. In contrast, the smooth parts of the left and right ventricles originate from the embryological bulbus cordis. The primitive ventricle becomes divided by a septum, the septum inferius or ventricular septum, which grows upward from the lower part of the ventricle, its position being indicated on the surface of the heart by a furrow. Its dorsal part increases more rapidly than its ventral portion, and fuses with the dorsal part of the septum intermedium. For a time an interventricular foramen exists above its ventral portion, but this foramen is ultimately closed by the fusion of the aortic septum with the ventricular septum[WP] synonym: "early heart ventricle" EXACT [] synonym: "embryonic heart ventricle" EXACT [] synonym: "embryonic ventricle" BROAD [] synonym: "future heart ventricle" EXACT [] synonym: "presumptive cardiac ventricle heart tube" EXACT [ZFA:0001719] synonym: "primitive ventricle" EXACT [EHDAA2:0001531] synonym: "primitive ventricle of heart" EXACT [EMAPA:16350] synonym: "primordial cardiac ventricle" EXACT [FMA:71006] synonym: "primordial ventricle" EXACT [FMA:71006] xref: EHDAA2:0001531 xref: EMAPA:16350 xref: FMA:71006 xref: NCIT:C34160 xref: SCTID:361524003 xref: TAO:0002231 xref: Wikipedia:Embryonic_ventricle xref: ZFA:0001719 is_a: UBERON:0006598 ! presumptive structure relationship: BFO:0000050 UBERON:0004141 {source="ZFA"} ! part of heart tube relationship: BFO:0000050 UBERON:0005498 {source="EMAPA"} ! part of primitive heart tube relationship: RO:0002387 UBERON:0002082 ! has potential to develop into cardiac ventricle property_value: skos:prefLabel "future cardiac ventricle" xsd:string [Term] id: UBERON:0006284 name: early prosencephalic vesicle def: "Future brain vesicle that gives rise to telencephalic ventricle/lateral ventricles and 3rd ventricle." [https://orcid.org/0000-0002-6601-2165] synonym: "forebrain ventricle" RELATED [VHOG:0000644] synonym: "forebrain vesicle" RELATED [VHOG:0000644] synonym: "preevaginated forebrain vesicle" NARROW [] synonym: "prosencephalic ventricle" RELATED [VHOG:0000644] synonym: "prosencephalic vesicle" EXACT [EHDAA2:0001571] xref: DHBA:10595 xref: EHDAA2:0001571 xref: EHDAA:1356 xref: EMAPA:16521 xref: SCTID:361480006 xref: TAO:0001259 xref: VHOG:0000644 xref: ZFA:0001259 is_a: UBERON:0013150 ! future brain vesicle relationship: BFO:0000050 UBERON:0006240 {source="EHDAA2"} ! part of future forebrain property_value: skos:prefLabel "early prosencephalic vesicle" xsd:string [Term] id: UBERON:0006288 name: rib cartilage element def: "A rib endochondral element that is composed primarily of cartilage tissue." [OBOL:automatic] subset: emapa_ehdaa2 xref: EHDAA2:0001716 xref: EHDAA:8347 xref: EMAPA:17678 xref: VHOG:0001122 is_a: UBERON:0005863 {source="EHDAA2"} ! cartilaginous condensation is_a: UBERON:0007844 ! cartilage element is_a: UBERON:0015019 ! rib endochondral element intersection_of: UBERON:0015019 ! rib endochondral element intersection_of: RO:0002473 UBERON:0002418 ! composed primarily of cartilage tissue relationship: RO:0002202 UBERON:0006289 {source="EHDAA2"} ! develops from rib pre-cartilage condensation relationship: RO:0002387 UBERON:0002228 ! has potential to develop into rib [Term] id: UBERON:0006289 name: rib pre-cartilage condensation def: "A rib endochondral element that is composed primarily of a pre-cartilage condensation." [OBOL:automatic] subset: emapa_ehdaa2 xref: EHDAA2:0001717 xref: EHDAA:6026 xref: EMAPA:17397 xref: VHOG:0000681 is_a: UBERON:0005866 {source="EHDAA2"} ! pre-cartilage condensation is_a: UBERON:0015019 ! rib endochondral element intersection_of: UBERON:0015019 ! rib endochondral element intersection_of: RO:0002473 UBERON:0005866 ! composed primarily of pre-cartilage condensation relationship: RO:0002202 UBERON:0003089 {source="EHDAA2-abduced", source="ZFA"} ! develops from sclerotome relationship: RO:0002387 UBERON:0002228 ! has potential to develop into rib relationship: RO:0002473 UBERON:0005866 ! composed primarily of pre-cartilage condensation [Term] id: UBERON:0006290 name: scapula cartilage element def: "A scapula endochondral element that is composed primarily of cartilage tissue." [OBOL:automatic] subset: emapa_ehdaa2 xref: EHDAA2:0001777 xref: EHDAA:8368 xref: EMAPA:18343 xref: VHOG:0001125 is_a: UBERON:0007844 ! cartilage element is_a: UBERON:0015057 ! scapula endochondral element intersection_of: UBERON:0015057 ! scapula endochondral element intersection_of: RO:0002473 UBERON:0002418 ! composed primarily of cartilage tissue relationship: BFO:0000050 UBERON:0000922 ! part of embryo relationship: RO:0002202 UBERON:0006291 {source="EHDAA2"} ! develops from scapula pre-cartilage condensation relationship: RO:0002387 UBERON:0006849 ! has potential to develop into scapula [Term] id: UBERON:0006291 name: scapula pre-cartilage condensation def: "A scapula endochondral element that is composed primarily of a pre-cartilage condensation." [OBOL:automatic] subset: emapa_ehdaa2 xref: EHDAA2:0001778 xref: EHDAA:6041 xref: EMAPA:18027 xref: VHOG:0000960 is_a: UBERON:0015057 ! scapula endochondral element intersection_of: UBERON:0015057 ! scapula endochondral element intersection_of: RO:0002473 UBERON:0005866 ! composed primarily of pre-cartilage condensation relationship: RO:0002202 UBERON:0006210 {source="EHDAA2"} ! develops from body-wall mesenchyme relationship: RO:0002387 UBERON:0006849 ! has potential to develop into scapula relationship: RO:0002473 UBERON:0005866 ! composed primarily of pre-cartilage condensation [Term] id: UBERON:0006292 name: shoulder joint primordium subset: emapa_ehdaa2 xref: EHDAA2:0001836 xref: EHDAA:8493 xref: EMAPA:17712 is_a: UBERON:0003322 ! mesenchyme of shoulder is_a: UBERON:0005856 {source="EHDAA2"} ! developing mesenchymal condensation relationship: BFO:0000050 UBERON:0003322 ! part of mesenchyme of shoulder relationship: RO:0002202 UBERON:0003322 {source="EHDAA2"} ! develops from mesenchyme of shoulder relationship: RO:0002387 UBERON:0001470 ! has potential to develop into glenohumeral joint [Term] id: UBERON:0006293 name: spleen primordium def: "A dense syncitial-like mesenchymal thickening in the dorsal mesogastrium[ISBN]. the embryonic connective tissue made up of loosely aggregated mesenchymal cells, supported by interlaminar jelly, that gives rise to the developing spleen[MP]." [ISBN:0123747295, MP:0011263] subset: pheno_slim synonym: "left spleen primordium" NARROW [XAO:0000326] synonym: "spleen mesenchyme" EXACT [MP:0011263] synonym: "splenic mesenchyme" EXACT [https://orcid.org/0000-0002-6601-2165] synonym: "splenic primordium" EXACT [EHDAA2:0001904] xref: EHDAA2:0001904 xref: EHDAA:3003 xref: EMAPA:18535 xref: XAO:0000326 is_a: BFO:0000002 is_a: UBERON:0001048 {source="XAO"} ! primordium is_a: UBERON:0003104 ! mesenchyme relationship: RO:0002202 UBERON:0004872 {source="XAO"} ! develops from splanchnic layer of lateral plate mesoderm property_value: skos:prefLabel "spleen primordium" xsd:string [Term] id: UBERON:0006297 name: sublingual gland primordium def: "A primordium that has the potential to develop into a sublingual gland." [OBOL:automatic] subset: emapa_ehdaa2 xref: EHDAA2:0001935 xref: EHDAA:7989 xref: EMAPA:17752 is_a: UBERON:0017651 ! salivary gland primordium intersection_of: UBERON:0001048 ! primordium intersection_of: RO:0002387 UBERON:0001832 ! has potential to develop into sublingual gland relationship: RO:0002387 UBERON:0001832 ! has potential to develop into sublingual gland [Term] id: UBERON:0006298 name: submandibular gland primordium def: "A primordium that has the potential to develop into a submandibular gland." [OBOL:automatic] subset: emapa_ehdaa2 synonym: "submaxillary gland primordium" RELATED [EMAPA:17755] xref: EHDAA2:0001939 xref: EHDAA:9255 xref: EMAPA:17755 is_a: BFO:0000002 is_a: UBERON:0017651 ! salivary gland primordium intersection_of: UBERON:0001048 ! primordium intersection_of: RO:0002387 UBERON:0001736 ! has potential to develop into submandibular gland relationship: BFO:0000050 UBERON:0001710 ! part of lower jaw region relationship: RO:0002254 UBERON:0002424 ! has developmental contribution from oral epithelium relationship: RO:0002254 UBERON:0006905 ! has developmental contribution from mandibular process mesenchyme relationship: RO:0002387 UBERON:0001736 ! has potential to develop into submandibular gland [Term] id: UBERON:0006304 name: future trigeminal ganglion comment: See: https://github.com/obophenotype/mouse-anatomy-ontology/issues/13 and https://github.com/obophenotype/uberon/issues/693 -- consider merging into trigeminal ganglion, as this complicates the model subset: emapa_ehdaa2 synonym: "trigeminal preganglion" RELATED [EMAPA:16663] synonym: "trigeminal V preganglion" EXACT [EMAPA:16663] xref: EHDAA:924 xref: EMAPA:16663 xref: RETIRED_EHDAA2:0002089 is_a: BFO:0000002 is_a: UBERON:0003869 ! presumptive ganglion relationship: RO:0002202 UBERON:0005563 ! develops from trigeminal neural crest relationship: RO:0002387 UBERON:0001675 ! has potential to develop into trigeminal ganglion relationship: RO:0002494 UBERON:0003070 {source="EHDAA2"} ! transformation of trigeminal placode complex property_value: skos:prefLabel "future trigeminal ganglion" xsd:string [Term] id: UBERON:0006311 name: chamber of eyeball def: "A segment of the eyeball that is filled with refractive media." [http://orcid.org/0000-0002-6601-2165] synonym: "chamber of eye" RELATED [BTO:0002085] synonym: "eye chamber" EXACT [MA:0002459] synonym: "eyeball chamber" EXACT [FMA:58071] xref: BTO:0002085 xref: EMAPA:37529 {source="MA:th"} xref: FMA:58071 xref: MA:0002459 xref: NCIT:C32301 xref: SCTID:280540004 xref: UMLS:C0459556 {source="ncithesaurus:Chamber_of_the_Eye"} is_a: UBERON:0000063 ! organ subunit intersection_of: UBERON:0000063 ! organ subunit intersection_of: BFO:0000050 UBERON:0000019 ! part of camera-type eye intersection_of: RO:0001015 UBERON:0006312 ! location of ocular refractive media relationship: BFO:0000050 UBERON:0000019 ! part of camera-type eye relationship: RO:0001015 UBERON:0006312 ! location of ocular refractive media property_value: skos:prefLabel "chamber of eyeball" xsd:string [Term] id: UBERON:0006312 name: ocular refractive media def: "Body substance in a liquid or semi-solid state in the eyeball which serves to refract light." [http://orcid.org/0000-0002-6601-2165] xref: MA:0001911 is_a: UBERON:0000463 ! organism substance relationship: BFO:0000050 UBERON:0000019 ! part of camera-type eye property_value: skos:prefLabel "ocular refractive media" xsd:string [Term] id: UBERON:0006314 name: bodily fluid def: "Liquid components of living organisms. includes fluids that are excreted or secreted from the body as well as body water that normally is not." [MESH:A12.207, Wikipedia:Body_fluid] subset: pheno_slim synonym: "body fluid" EXACT [GAID:266] synonym: "fluid" BROAD [] xref: BIRNLEX:20 xref: EMAPA:37441 {source="MA:th"} xref: FMA:280556 xref: GAID:266 xref: galen:BodyFluid xref: MESH:D001826 xref: Wikipedia:Body_fluid is_a: UBERON:0000463 ! organism substance intersection_of: UBERON:0000463 ! organism substance intersection_of: RO:0000086 PATO:0001548 ! has quality quality of a liquid relationship: RO:0000086 PATO:0001548 ! has quality quality of a liquid property_value: skos:prefLabel "bodily fluid" xsd:string [Term] id: UBERON:0006331 name: brainstem nucleus def: "A nucleus of brain that is part of a brainstem." [OBOL:automatic] synonym: "brain stem nucleus" RELATED [EMAPA:32790] xref: EMAPA:32790 xref: MA:0000821 is_a: UBERON:0002308 ! nucleus of brain intersection_of: UBERON:0002308 ! nucleus of brain intersection_of: BFO:0000050 UBERON:0002298 ! part of brainstem relationship: BFO:0000050 UBERON:0002298 ! part of brainstem property_value: skos:prefLabel "brainstem nucleus" xsd:string [Term] id: UBERON:0006334 name: posterior lateral line def: "One of eight distinct lateral lines in the 4-day larva. A sensory system on the surface of the fish, consisting of small sensory patches (neuromasts) distributed in discrete lines over the body surface. The lateral line system is stimulated by local water displacements and vibrations, and detects propulsion of the fish through the water, as well as facilitating shoaling, prey capture, and predator and obstacle avoidance." [ZFA:0000944] subset: dubious_grouping subset: efo_slim synonym: "pll" EXACT [ZFA:0000944] xref: AAO:0011024 xref: EFO:0003595 xref: TAO:0000944 xref: XAO:0000465 xref: ZFA:0000944 is_a: UBERON:0010202 ! lateral line disjoint_from: UBERON:2001470 {source="lexical"} ! anterior lateral line property_value: IAO:0000116 "check XAO/AAO" xsd:string [Term] id: UBERON:0006338 name: lateral ventricle choroid plexus stroma def: "A choroid plexus stroma that is part of a lateral ventricle." [OBOL:automatic] xref: MA:0000963 is_a: UBERON:0005206 ! choroid plexus stroma intersection_of: UBERON:0005206 ! choroid plexus stroma intersection_of: BFO:0000050 UBERON:0002285 ! part of telencephalic ventricle relationship: BFO:0000050 UBERON:0002307 ! part of choroid plexus of lateral ventricle property_value: IAO:0000116 "definitions should be fixed to use generic stroma class" xsd:string [Term] id: UBERON:0006339 name: third ventricle choroid plexus stroma def: "A choroid plexus stroma that is part of a third ventricle." [OBOL:automatic] xref: EMAPA:37056 {source="MA:th"} xref: MA:0000881 is_a: UBERON:0005206 ! choroid plexus stroma intersection_of: UBERON:0005206 ! choroid plexus stroma intersection_of: BFO:0000050 UBERON:0002286 ! part of third ventricle relationship: BFO:0000050 UBERON:0002288 ! part of choroid plexus of third ventricle [Term] id: UBERON:0006340 name: fourth ventricle choroid plexus stroma def: "A choroid plexus stroma that is part of a fourth ventricle." [OBOL:automatic] xref: MA:0000985 is_a: UBERON:0005206 ! choroid plexus stroma intersection_of: UBERON:0005206 ! choroid plexus stroma intersection_of: BFO:0000050 UBERON:0002422 ! part of fourth ventricle relationship: BFO:0000050 UBERON:0002290 ! part of choroid plexus of fourth ventricle [Term] id: UBERON:0006341 name: outer renal medulla peritubular capillary def: "A peritubular capillary that is part of a outer medulla of kidney." [OBOL:automatic] synonym: "kidney outer medulla peritubular capillary" EXACT [MA:0002589] xref: EMAPA:35461 xref: MA:0002589 is_a: UBERON:0005272 ! peritubular capillary intersection_of: UBERON:0005272 ! peritubular capillary intersection_of: BFO:0000050 UBERON:0001293 ! part of outer medulla of kidney relationship: BFO:0000050 UBERON:0001293 ! part of outer medulla of kidney [Term] id: UBERON:0006347 name: communicating artery def: "An artery that connects two larger arteries." [ncithesaurus:Communicating_Artery] comment: Grouping for anterior and posterior xref: EMAPA:18598 xref: MA:0001938 xref: NCIT:C52851 xref: UMLS:C1707451 {source="ncithesaurus:Communicating_Artery"} is_a: UBERON:0001637 ! artery intersection_of: UBERON:0001637 ! artery intersection_of: RO:0002176 UBERON:0001637 {cardinality="2"} ! connects artery relationship: RO:0002176 UBERON:0001637 ! connects artery property_value: skos:prefLabel "communicating artery" xsd:string [Term] id: UBERON:0006355 name: superior vesical vein subset: human_reference_atlas xref: EMAPA:18646 xref: MA:0002227 is_a: UBERON:0002460 {is_inferred="true", source="MA"} ! vesical vein intersection_of: UBERON:0001638 ! vein intersection_of: RO:0020102 UBERON:0000056 ! vessel drains blood from ureter relationship: RO:0020102 UBERON:0000056 ! vessel drains blood from ureter property_value: IAO:0000116 "inferred from artery" xsd:string property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0006376 name: premacula segment of distal straight tubule def: "Missing definition for term UBERON:0006376. Please replace it using linked reference." [PMID:14595018] synonym: "distal straight tubule premacula segment" EXACT [MA:0002628] synonym: "kidney medulla loop of Henle ascending limb thick segment" EXACT [MA:th] synonym: "medullary thick ascending limb of Henle's loop" EXACT [MA:th] synonym: "renal medulla loop of Henle ascending limb thick segment" EXACT [MA:th] synonym: "renal medulla thick ascending limb" EXACT [MA:th] xref: EMAPA:29671 xref: MA:0002628 is_a: UBERON:0007685 ! region of nephron tubule relationship: BFO:0000050 UBERON:0001291 {source="MA"} ! part of thick ascending limb of loop of Henle relationship: BFO:0000050 UBERON:0006541 {source="MA"} ! part of outer medulla inner stripe loop of Henle relationship: BFO:0000050 UBERON:0006542 {source="MA"} ! part of outer medulla outer stripe loop of Henle property_value: IAO:0000233 "https://sourceforge.net/tracker/?func=detail&aid=3123600&group_id=76834&atid=1205376" xsd:anyURI [Term] id: UBERON:0006435 name: os penis def: "The unique bone located in the glans penis of most mammals except humans; it is used for copulation and varies in size and shape by species." [MGI:anna, MP:0009103] subset: pheno_slim synonym: "baculum" EXACT [Wikipedia:Baculum] synonym: "os baculum" EXACT [] synonym: "penile bone" EXACT [MP:0009104, Wikipedia:Baculum] synonym: "penis bone" EXACT [Wikipedia:Baculum] xref: EMAPA:29769 xref: MA:0000406 xref: SCTID:27962002 xref: Wikipedia:Baculum is_a: UBERON:0007719 ! bone of reproductive organ intersection_of: UBERON:0001474 ! bone element intersection_of: BFO:0000050 UBERON:0000989 ! part of penis relationship: BFO:0000050 UBERON:0000989 ! part of penis relationship: RO:0002162 NCBITaxon:40674 {source="Wikipedia"} ! in taxon Mammalia property_value: RO:0002161 NCBITaxon:9606 [Term] id: UBERON:0006440 name: os clitoris def: "The ossified region of endochondral and membranous bone located in the clitoris of most mammals except humans; it is homologous to the penile bone (aka as baculum, penis bone or os penis) in male mammals." [MP:0011849] subset: pheno_slim synonym: "baubellum" EXACT [Wikipedia:Baculum] synonym: "clitoral bone" EXACT [MP:0011849] synonym: "clitoris bone" EXACT [] synonym: "os clitoridis" EXACT [Wikipedia:Baculum] xref: EMAPA:30823 xref: MA:0000387 is_a: UBERON:0007719 ! bone of reproductive organ intersection_of: UBERON:0001474 ! bone element intersection_of: BFO:0000050 UBERON:0002411 ! part of clitoris relationship: BFO:0000050 UBERON:0002411 ! part of clitoris relationship: RO:0002433 UBERON:0001434 ! contributes to morphology of skeletal system relationship: RO:0002433 UBERON:0002411 ! contributes to morphology of clitoris relationship: sexually_homologous_to UBERON:0006435 ! os penis property_value: RO:0002161 NCBITaxon:9606 [Term] id: UBERON:0006444 name: annulus fibrosus def: "A ring of fibrous or fibrocartilaginous tissue (as of an intervertebral disk or surrounding an orifice of the heart)." [BTO:0003627] subset: grouping_class synonym: "anulus" BROAD [BTO:0003627] synonym: "anulus fibrosus" EXACT [FMA:76704] synonym: "fibrocartilaginous ring" EXACT [http://orcid.org/0000-0002-6601-2165] synonym: "fibrous ring" RELATED [BTO:0003627] xref: BTO:0003627 xref: FMA:76704 is_a: UBERON:0001995 ! fibrocartilage [Term] id: UBERON:0006514 name: pallidum def: "Part of what are called the basal ganglia of the brain which consist of the globus pallidus and the ventral pallidum." [http://www.medterms.com/script/main/art.asp?articlekey=11614] synonym: "neuraxis pallidum" EXACT [FMA:83684] synonym: "pallidum of neuraxis" EXACT [FMA:83684] xref: BAMS:PAL xref: EMAPA:32780 xref: FMA:83684 xref: MA:0000889 xref: MBA:803 xref: MESH:D005917 {sssom:mapping_justification="https://w3id.org/semapv/vocab/LexicalMatching"} xref: neuronames:2673 is_a: UBERON:0003528 ! brain gray matter relationship: BFO:0000050 UBERON:0002420 {source="MA"} ! part of basal ganglion property_value: skos:prefLabel "pallidum" xsd:string [Term] id: UBERON:0006516 name: dorsal pallidum def: "The predominant portion of the globus pallidus in the striatopallidal system, which is defined by connectivity and neurochemical staining. The dorsal pallidum is distinguished from the ventral pallidum by a boundary that is partially defined by the anterior commissure. The remainder of the boundary is indistinct in sections stained for Nissl substance ( Heimer-1995 )." [NeuroNames:1604] synonym: "dorsal globus pallidus" RELATED [BTO:0004376] synonym: "globus pallidus dorsal part" EXACT [http://orcid.org/0000-0002-6601-2165] synonym: "pallidum dorsal region" RELATED [BAMS:PALd] xref: BAMS:PALd xref: BTO:0004376 xref: FMA:77619 xref: MBA:818 xref: neuronames:1604 is_a: UBERON:0005401 ! cerebral hemisphere gray matter is_a: UBERON:0006514 {source="FMA"} ! pallidum relationship: BFO:0000050 UBERON:0001875 {source="BTO"} ! part of globus pallidus property_value: skos:prefLabel "dorsal pallidum" xsd:string [Term] id: UBERON:0006518 name: right lung lobe def: "A lobe of lung that is part of a right lung." [OBOL:automatic] synonym: "lobe of right lung" EXACT [] synonym: "lobe of the right lung" EXACT [ncithesaurus:Lobe_of_the_Right_Lung] xref: EMAPA:35155 xref: MA:0001791 xref: NCIT:C48944 xref: SCTID:272654004 xref: UMLS:C1285106 {source="ncithesaurus:Lobe_of_the_Right_Lung"} is_a: UBERON:0000101 ! lobe of lung intersection_of: UBERON:0000101 ! lobe of lung intersection_of: BFO:0000050 UBERON:0002167 ! part of right lung relationship: BFO:0000050 UBERON:0002167 ! part of right lung property_value: skos:prefLabel "right lung lobe" xsd:string [Term] id: UBERON:0006524 name: alveolar system def: "System pertaining to a bronchus and alveoli." [BTO:0000136] subset: pheno_slim synonym: "bronchoalveolar system" RELATED [BTO:0000136] synonym: "pulmonary alveolar system" EXACT [MP:0010899] xref: BTO:0000136 xref: CALOHA:TS-1296 xref: EMAPA:32692 xref: MA:0000416 is_a: UBERON:0011216 ! organ system subdivision relationship: BFO:0000050 UBERON:0002048 ! part of lung relationship: RO:0002433 UBERON:0002048 ! contributes to morphology of lung [Term] id: UBERON:0006525 name: left lung alveolar system xref: EMAPA:19001 xref: MA:0001775 is_a: UBERON:0011216 ! organ system subdivision relationship: BFO:0000050 UBERON:0002168 ! part of left lung relationship: BFO:0000050 UBERON:0006524 ! part of alveolar system [Term] id: UBERON:0006526 name: right lung alveolar system xref: EMAPA:35717 xref: MA:0001784 is_a: UBERON:0011216 ! organ system subdivision relationship: BFO:0000050 UBERON:0002167 ! part of right lung relationship: BFO:0000050 UBERON:0006524 ! part of alveolar system [Term] id: UBERON:0006530 name: seminal fluid def: "A substance formed from the secretion of one or more glands of the male genital tract in which sperm cells are suspended." [http://orcid.org/0000-0002-6601-2165] synonym: "male genital fluid" RELATED [] synonym: "male genital secretion" RELATED [] synonym: "milt" NARROW [PMID:31287811, PMID:35203131] {comment="CURATOR NOTE A secretion from the glands of the male reproductive system in some aquatic animals that contains sperm and is sprayed onto the eggs."} synonym: "seminal fluid" RELATED [BTO:0001232] synonym: "seminal plasma" EXACT [BTO:0001232] xref: BTO:0001232 xref: CALOHA:TS-0918 xref: EMAPA:36543 xref: FMA:62967 xref: MA:0002523 xref: MAT:0000057 xref: MIAA:0000057 is_a: UBERON:0000456 ! secretion of exocrine gland is_a: UBERON:0006536 ! male reproductive gland secretion intersection_of: UBERON:0000456 ! secretion of exocrine gland intersection_of: BFO:0000050 UBERON:0001968 ! part of semen intersection_of: RO:0003001 UBERON:0005399 ! produced by male reproductive gland relationship: BFO:0000050 UBERON:0001968 ! part of semen relationship: RO:0002216 GO:0048240 ! capable of part of sperm capacitation relationship: RO:0002216 GO:1902093 ! capable of part of positive regulation of flagellated sperm motility [Term] id: UBERON:0006534 name: renal convoluted tubule def: "Any region of a nephron tubule that is convoluted. Examples: distal convoluted tubule, proximal convoluted tuble." [http://orcid.org/0000-0002-6601-2165] subset: grouping_class synonym: "convoluted tubule" EXACT [] synonym: "kidney convoluted tubule" EXACT [MA:0001665] xref: EMAPA:35725 xref: MA:0001665 xref: NCIT:C49479 xref: SCTID:361333002 xref: UMLS:C1707510 {source="ncithesaurus:Convoluted_Tubule"} xref: Wikipedia:Convoluted_tubule is_a: UBERON:0007685 ! region of nephron tubule [Term] id: UBERON:0006535 name: skin secretion def: "A portion of organism substance that secreted_by a zone of skin." [OBOL:automatic] synonym: "skin fluid" RELATED [] synonym: "skin fluid/secretion" EXACT [MA:0002537] synonym: "skin substance" RELATED [] xref: MA:0002537 is_a: UBERON:0000463 ! organism substance intersection_of: UBERON:0000463 ! organism substance intersection_of: RO:0003001 UBERON:0000014 ! produced by zone of skin relationship: RO:0003001 UBERON:0000014 ! produced by zone of skin property_value: skos:prefLabel "skin secretion" xsd:string [Term] id: UBERON:0006536 name: male reproductive gland secretion def: "A portion of organism substance that is secreted by a male reproductive gland." [UBERON:cjm] synonym: "male reproductive system fluid" RELATED [] synonym: "male reproductive system fluid/secretion" EXACT [MA:0002521] synonym: "male reproductive system secretion" RELATED [] xref: EMAPA:36541 xref: MA:0002521 is_a: UBERON:0022293 ! reproductive gland secretion intersection_of: UBERON:0000463 ! organism substance intersection_of: RO:0003001 UBERON:0005399 ! produced by male reproductive gland relationship: RO:0003001 UBERON:0005399 ! produced by male reproductive gland [Term] id: UBERON:0006537 name: female reproductive gland secretion def: "A portion of organism substance that is secreted by a female reproductive gland." [UBERON:cjm] synonym: "female reproductive system fluid" RELATED [] synonym: "female reproductive system fluid/secretion" EXACT [MA:0002510] synonym: "female reproductive system secretion" RELATED [] xref: MA:0002510 is_a: UBERON:0022293 ! reproductive gland secretion intersection_of: UBERON:0000463 ! organism substance intersection_of: RO:0003001 UBERON:0005398 ! produced by female reproductive gland relationship: RO:0003001 UBERON:0005398 ! produced by female reproductive gland property_value: skos:prefLabel "female reproductive gland secretion" xsd:string [Term] id: UBERON:0006538 name: respiratory system fluid/secretion def: "A portion of organism substance that secreted_by a respiratory system." [OBOL:automatic] synonym: "respiratory system fluid" RELATED [] synonym: "respiratory system secretion" RELATED [] xref: EMAPA:36550 xref: MA:0002533 xref: NCIT:C13722 xref: UMLS:C1514899 {source="ncithesaurus:Respiratory_System_Fluid_or_Secretion"} is_a: UBERON:0000463 ! organism substance intersection_of: UBERON:0000463 ! organism substance intersection_of: RO:0003001 UBERON:0001004 ! produced by respiratory system relationship: RO:0003001 UBERON:0001004 ! produced by respiratory system property_value: skos:prefLabel "respiratory system fluid/secretion" xsd:string [Term] id: UBERON:0006539 name: mammary gland fluid/secretion def: "A substance that is secreted by a mammary gland. The substance may differ depending on phase, with colostrum produced during pregancy/early lactation, and milk produced afterwards." [http://orcid.org/0000-0002-6601-2165] synonym: "lactiferous gland fluid" RELATED [] synonym: "lactiferous gland secretion" RELATED [] synonym: "mammary gland fluid" RELATED [] synonym: "mammary gland secreted fluid" RELATED [] synonym: "mammary gland secretion" RELATED [] synonym: "secretion of mammary gland" RELATED [] xref: EMAPA:36538 xref: MA:0002505 is_a: UBERON:0000456 ! secretion of exocrine gland intersection_of: UBERON:0000463 ! organism substance intersection_of: RO:0003001 UBERON:0001911 ! produced by mammary gland relationship: RO:0003001 UBERON:0001911 ! produced by mammary gland [Term] id: UBERON:0006541 name: outer medulla inner stripe loop of Henle def: "A loop of Henle that is part of a kidney outer medulla inner stripe." [OBOL:automatic] xref: EMAPA:29679 xref: MA:0002627 is_a: UBERON:0034996 ! outer renal medulla loop of Henle intersection_of: UBERON:0001288 ! loop of Henle intersection_of: BFO:0000050 UBERON:0004201 ! part of kidney outer medulla inner stripe relationship: BFO:0000050 UBERON:0004201 ! part of kidney outer medulla inner stripe [Term] id: UBERON:0006542 name: outer medulla outer stripe loop of Henle def: "A loop of Henle that is part of a kidney outer medulla outer stripe." [OBOL:automatic] xref: EMAPA:29665 xref: MA:0002630 is_a: UBERON:0034996 ! outer renal medulla loop of Henle intersection_of: UBERON:0001288 ! loop of Henle intersection_of: BFO:0000050 UBERON:0004202 ! part of kidney outer medulla outer stripe relationship: BFO:0000050 UBERON:0004202 ! part of kidney outer medulla outer stripe [Term] id: UBERON:0006544 name: kidney vasculature def: "A vasculature that is part of a kidney." [OBOL:automatic] subset: human_reference_atlas subset: vertebrate_core xref: EMAPA:28457 xref: TAO:0005305 xref: ZFA:0005305 is_a: UBERON:0002201 ! vasculature of trunk is_a: UBERON:0006876 ! vasculature of organ intersection_of: UBERON:0002049 ! vasculature intersection_of: BFO:0000050 UBERON:0002113 ! part of kidney relationship: BFO:0000050 UBERON:0002113 ! part of kidney property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0006553 name: renal duct def: "A tube in the kidney that collect and transport urine." [ZFIN:ZDB-PUB-071029-9] xref: TAO:0005289 xref: ZFA:0005289 is_a: UBERON:0000058 ! duct intersection_of: UBERON:0000058 ! duct intersection_of: BFO:0000050 UBERON:0002113 ! part of kidney relationship: BFO:0000050 UBERON:0002113 ! part of kidney [Term] id: UBERON:0006555 name: excretory tube def: "A tube that is part of a excretory system." [OBOL:automatic] is_a: UBERON:0000025 ! tube intersection_of: UBERON:0000025 ! tube intersection_of: BFO:0000050 UBERON:0001008 ! part of renal system relationship: BFO:0000050 UBERON:0001008 ! part of renal system property_value: skos:prefLabel "excretory tube" xsd:string [Term] id: UBERON:0006558 name: lymphatic part of lymphoid system def: "An organ system subdivision that is a network of vessels capable of removing accumulating protein and fluid from the interstitial space and returning it to the vascular space. In some species, this network is connected to the immune system via lymph nodes and lymphocyte-producing organs, with the whole being the lymphoid system." [http://orcid.org/0000-0002-6601-2165] subset: efo_slim subset: human_reference_atlas subset: pheno_slim synonym: "lymphatic system" EXACT [FMA:7162, MA:0002435] synonym: "lymphatic tree system" EXACT [FMA:7162] synonym: "lymporeticular system" RELATED [VHOG:0001761] xref: AAO:0010522 xref: CALOHA:TS-2024 xref: EFO:0000870 xref: EMAPA:18248 xref: FMA:7162 xref: MA:0002961 xref: MESH:D008208 xref: SCTID:362597000 xref: VHOG:0001761 xref: Wikipedia:Lymphatic_system is_a: UBERON:0011216 ! organ system subdivision relationship: BFO:0000050 UBERON:0001009 {source="AAO"} ! part of circulatory system relationship: BFO:0000050 UBERON:0002465 {source="FMA", source="MA"} ! part of lymphoid system property_value: IAO:0000116 "consider merging with lymph vasculature" xsd:string property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0006561 name: non-lymphatic part of lymphoid system def: "An organ system subdivision that is the part of the lymphoid system that excludes the lymphatic vessels.." [http://orcid.org/0000-0002-6601-2165] synonym: "non-lymphatic lymphoid system" EXACT [FMA:74623] xref: FMA:74623 is_a: UBERON:0011216 ! organ system subdivision relationship: BFO:0000050 UBERON:0002465 ! part of lymphoid system [Term] id: UBERON:0006562 name: pharynx def: "The pharynx is the part of the digestive system immediately posterior to the mouth[GO]." [GO:0060465] subset: grouping_class subset: uberon_slim synonym: "anterior part of foregut" RELATED [] synonym: "pharyngeal tube" RELATED [] xref: MAT:0000049 xref: MESH:D010614 xref: MIAA:0000049 is_a: UBERON:0004921 ! subdivision of digestive tract relationship: RO:0002162 NCBITaxon:33213 ! in taxon Bilateria property_value: skos:prefLabel "pharynx" xsd:string [Term] id: UBERON:0006563 name: tunica media of pulmonary trunk def: "Tunica media of artery which is continuous with the myocardium of right ventricle.[FMA]." [FMA:85030, FMA:FMA] xref: FMA:85030 is_a: UBERON:0007239 ! tunica media of artery intersection_of: UBERON:0002522 ! tunica media intersection_of: BFO:0000050 UBERON:0002333 ! part of pulmonary trunk relationship: BFO:0000050 UBERON:0002333 ! part of pulmonary trunk property_value: skos:prefLabel "tunica media of pulmonary trunk" xsd:string [Term] id: UBERON:0006565 name: female urethral meatus def: "A urethral meatus that is part of a female urethra[Automatically generated definition]." [OBOL:automatic, Wikipedia:External_urethral_orifice_(female)] synonym: "distal urethral opening of female" RELATED [EMAPA:36453] synonym: "external orifice of female urethra" EXACT [FMA:85266] synonym: "external urethral orifice (female)" EXACT [FMA:85266] synonym: "female urethral meatus" EXACT [FMA:85266] synonym: "ostium urethrae externum (urethra feminina)" EXACT OMO:0003011 [FMA:85266, FMA:TA] synonym: "urethral meatus of clitoral urethra" EXACT [EMAPA:36453] synonym: "urethral opening of clitoral urethra" RELATED [EMAPA:36453] xref: EMAPA:36453 xref: FMA:85266 xref: MA:0002639 xref: SCTID:279479008 xref: Wikipedia:External_urethral_orifice_(female) is_a: UBERON:0012240 ! urethral meatus intersection_of: UBERON:0012240 ! urethral meatus intersection_of: BFO:0000050 UBERON:0003100 ! part of female organism relationship: BFO:0000050 UBERON:0001334 ! part of female urethra [Term] id: UBERON:0006566 name: left ventricle myocardium def: "A myocardium that is part of a left ventricle of a heart." [http://orcid.org/0000-0002-6601-2165] subset: human_reference_atlas synonym: "left ventricular myocardium" EXACT [FMA:9558] synonym: "myocardium of left ventricle" EXACT [FMA:9558] xref: FMA:9558 xref: MA:0002983 xref: SCTID:362021000 is_a: UBERON:0001083 ! myocardium of ventricle intersection_of: UBERON:0001083 ! myocardium of ventricle intersection_of: BFO:0000050 UBERON:0002084 ! part of heart left ventricle relationship: BFO:0000050 UBERON:0002084 ! part of heart left ventricle relationship: RO:0002150 UBERON:0003618 ! continuous with aorta tunica media property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "left ventricle myocardium" xsd:string [Term] id: UBERON:0006567 name: right ventricle myocardium def: "A myocardium that is part of a right ventricle of a heart." [http://orcid.org/0000-0002-6601-2165] subset: human_reference_atlas subset: pheno_slim synonym: "myocardium of right ventricle" EXACT [FMA:9535] synonym: "right ventricular myocardium" EXACT [FMA:9535] xref: FMA:9535 xref: MA:0002984 xref: SCTID:362020004 is_a: UBERON:0001083 ! myocardium of ventricle intersection_of: UBERON:0001083 ! myocardium of ventricle intersection_of: BFO:0000050 UBERON:0002080 ! part of heart right ventricle relationship: BFO:0000050 UBERON:0002080 ! part of heart right ventricle relationship: RO:0002150 UBERON:0006563 ! continuous with tunica media of pulmonary trunk property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "right ventricle myocardium" xsd:string [Term] id: UBERON:0006568 name: hypothalamic nucleus def: "A nucleus of brain that is part of a hypothalamus." [OBOL:automatic] synonym: "nucleus of hypothalamus" EXACT [FMA:258762] xref: BTO:0002449 xref: EMAPA:35417 xref: FMA:258762 xref: MA:0002426 xref: SCTID:279304003 is_a: UBERON:0006569 ! diencephalic nucleus intersection_of: UBERON:0002308 ! nucleus of brain intersection_of: BFO:0000050 UBERON:0001898 ! part of hypothalamus relationship: BFO:0000050 UBERON:0001898 ! part of hypothalamus property_value: skos:prefLabel "hypothalamic nucleus" xsd:string [Term] id: UBERON:0006569 name: diencephalic nucleus def: "A nucleus of brain that is part of a diencephalon." [OBOL:automatic] xref: TAO:0002191 xref: ZFA:0001659 is_a: UBERON:0002308 ! nucleus of brain intersection_of: UBERON:0002308 ! nucleus of brain intersection_of: BFO:0000050 UBERON:0001894 ! part of diencephalon relationship: BFO:0000050 UBERON:0001894 ! part of diencephalon property_value: skos:prefLabel "diencephalic nucleus" xsd:string [Term] id: UBERON:0006570 name: trabecula carnea of right ventricle def: "A trabecula carnea that is part of a heart right ventricle." [OBOL:automatic] synonym: "trabeculae carneae (ventriculus dexter)" EXACT [FMA:7270] xref: FMA:7270 xref: SCTID:192373001 is_a: UBERON:0002511 ! trabecula carnea intersection_of: UBERON:0002511 ! trabecula carnea intersection_of: BFO:0000050 UBERON:0002080 ! part of heart right ventricle relationship: BFO:0000050 UBERON:0002080 ! part of heart right ventricle [Term] id: UBERON:0006571 name: trabecula carnea of left ventricle def: "A trabecula carnea that is part of a heart left ventricle." [OBOL:automatic] synonym: "trabeculae carneae (ventriculus sinister)" EXACT [FMA:7271] xref: FMA:7271 xref: SCTID:190344008 is_a: UBERON:0002511 ! trabecula carnea intersection_of: UBERON:0002511 ! trabecula carnea intersection_of: BFO:0000050 UBERON:0002084 ! part of heart left ventricle relationship: BFO:0000050 UBERON:0002084 ! part of heart left ventricle [Term] id: UBERON:0006574 name: pectinate line def: "The pectinate line (anocutaneous line, dentate line, anorectal junction) is a line which divides the upper 2/3rds and lower 1/3rd of the anal canal. Developmentally, this line represents the hindgut-proctodeum junction. It is an important anatomical landmark, and several distinctions can be made based upon the location of a structure relative to this line:." [Wikipedia:Pectinate_line] synonym: "dentate line" RELATED [Wikipedia:Pectinate_line] synonym: "Hilton's 'white line'" RELATED [EMAPA:19159] synonym: "linea anocutanea" RELATED OMO:0003011 [Wikipedia:Pectinate_line] synonym: "linea pectinata canalis analis" EXACT OMO:0003011 [FMA:75383, FMA:TA] synonym: "pectinate line of anal canal" EXACT [FMA:75383] synonym: "recto-anal junction" RELATED [Wikipedia:Pectinate_line] synonym: "site of anal membrane" RELATED [EMAPA:19159] xref: EMAPA:19159 xref: FMA:75383 xref: NCIT:C34245 xref: SCTID:245445008 xref: UMLS:C0821671 {source="ncithesaurus:Pectinate_Line"} xref: Wikipedia:Pectinate_line is_a: UBERON:8410024 ! intestinal junction intersection_of: UBERON:0007651 ! anatomical junction intersection_of: RO:0002176 UBERON:0000931 ! connects proctodeum intersection_of: RO:0002176 UBERON:0001046 ! connects hindgut relationship: BFO:0000050 UBERON:0000159 ! part of anal canal relationship: RO:0002176 UBERON:0000931 ! connects proctodeum relationship: RO:0002176 UBERON:0001046 ! connects hindgut property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/7/7b/Hemorrhoid.png" xsd:anyURI property_value: skos:prefLabel "pectinate line" xsd:string [Term] id: UBERON:0006585 name: vestibular organ def: "An organ that is part of a vestibular system." [OBOL:automatic] synonym: "balance organ" EXACT [https://orcid.org/0000-0002-6601-2165] xref: BIRNLEX:2519 xref: UMLS:C0682674 {source="BIRNLEX:2519"} is_a: UBERON:0000062 ! organ intersection_of: UBERON:0000062 ! organ intersection_of: BFO:0000050 UBERON:0004681 ! part of vestibular system relationship: BFO:0000050 UBERON:0000012 {source="NIFSTD"} ! part of somatic nervous system relationship: BFO:0000050 UBERON:0004681 ! part of vestibular system property_value: skos:prefLabel "vestibular organ" xsd:string [Term] id: UBERON:0006586 name: otolymph def: "Transudate located within the osseus labyrinth. Otolymph can be further classified with respect to whether it is within the membranous labyrinth (endolymph) or outside the mebranous labyrinth (perilymph)." [http://orcid.org/0000-0002-6601-2165] synonym: "labyrinthine fluid" RELATED [MESH:A12.207.571] xref: EMAPA:36547 xref: GAID:1183 xref: MA:0002527 xref: MESH:D007761 xref: NCIT:C33231 xref: UMLS:C1518679 {source="ncithesaurus:Otolymph"} is_a: UBERON:0007779 {source="FMA-abduced"} ! transudate relationship: BFO:0000050 UBERON:0001844 {source="Wikipedia:Perilymph"} ! part of cochlea relationship: RO:0001025 UBERON:0001839 ! located in bony labyrinth [Term] id: UBERON:0006595 name: presumptive endoderm def: "Presumptive structure of the blastula that will develop into endoderm." [http://orcid.org/0000-0002-6601-2165] subset: efo_slim xref: AAO:0000471 xref: EFO:0003437 xref: TAO:0000416 xref: ZFA:0000416 is_a: UBERON:0006598 ! presumptive structure intersection_of: UBERON:0006598 ! presumptive structure intersection_of: BFO:0000050 UBERON:0000307 ! part of blastula intersection_of: RO:0002387 UBERON:0000925 ! has potential to develop into endoderm relationship: BFO:0000050 UBERON:0000307 ! part of blastula relationship: RO:0002387 UBERON:0000925 ! has potential to develop into endoderm property_value: skos:prefLabel "presumptive endoderm" xsd:string [Term] id: UBERON:0006596 name: presumptive blood subset: efo_slim synonym: "future blood" EXACT [] xref: AAO:0000468 xref: EFO:0003439 xref: TAO:0000568 xref: ZFA:0000568 is_a: UBERON:0006598 ! presumptive structure intersection_of: UBERON:0006598 ! presumptive structure intersection_of: RO:0002387 UBERON:0000178 ! has potential to develop into blood relationship: RO:0002387 UBERON:0000178 ! has potential to develop into blood property_value: skos:prefLabel "presumptive blood" xsd:string [Term] id: UBERON:0006598 name: presumptive structure def: "Portion of embryonic tissue determined by fate mapping to become a structure." [GOC:CVS, GOC:YMB, ZFA:0001116] synonym: "future structure" EXACT [] synonym: "presumptive structures" EXACT [ZFA:0001116] xref: AAO:0000479 xref: TAO:0001116 xref: ZFA:0001116 is_a: UBERON:0002050 ! embryonic structure intersection_of: UBERON:0005423 ! developing anatomical structure intersection_of: BFO:0000050 UBERON:0000922 ! part of embryo intersection_of: RO:0002387 UBERON:0000061 ! has potential to develop into anatomical structure relationship: RO:0002387 UBERON:0000061 ! has potential to develop into anatomical structure property_value: IAO:0000116 "Consider merging with anlage" xsd:string property_value: skos:prefLabel "presumptive structure" xsd:string [Term] id: UBERON:0006600 name: presumptive enteric nervous system subset: efo_slim synonym: "future enteric nervous system" EXACT [] xref: AAO:0000472 xref: EFO:0003462 xref: TAO:0001334 xref: ZFA:0001334 is_a: BFO:0000002 is_a: UBERON:0006598 ! presumptive structure intersection_of: UBERON:0006598 ! presumptive structure intersection_of: RO:0002387 UBERON:0002005 ! has potential to develop into enteric nervous system relationship: RO:0002202 UBERON:0005428 {source="NCBIBook:NBK10065"} ! develops from vagal neural crest relationship: RO:0002387 UBERON:0002005 ! has potential to develop into enteric nervous system [Term] id: UBERON:0006601 name: presumptive ectoderm def: "Presumptive structure of the blastula that will develop into ectoderm." [http://orcid.org/0000-0002-6601-2165] subset: efo_slim synonym: "presumptive epidermis" RELATED [ZFA:0001376] xref: AAO:0000470 xref: EFO:0003466 xref: TAO:0001376 xref: XAO:0004132 xref: ZFA:0001376 is_a: UBERON:0006598 ! presumptive structure intersection_of: UBERON:0006598 ! presumptive structure intersection_of: BFO:0000050 UBERON:0000307 ! part of blastula intersection_of: RO:0002387 UBERON:0000924 ! has potential to develop into ectoderm relationship: BFO:0000050 UBERON:0000307 ! part of blastula relationship: RO:0002387 UBERON:0000924 ! has potential to develop into ectoderm property_value: skos:prefLabel "presumptive ectoderm" xsd:string [Term] id: UBERON:0006603 name: presumptive mesoderm def: "Presumptive structure of the blastula that will develop into mesoderm." [http://orcid.org/0000-0002-6601-2165] subset: efo_slim xref: AAO:0000476 xref: EFO:0003467 xref: TAO:0001377 xref: ZFA:0001377 is_a: UBERON:0006598 ! presumptive structure intersection_of: UBERON:0006598 ! presumptive structure intersection_of: BFO:0000050 UBERON:0000307 ! part of blastula intersection_of: RO:0002387 UBERON:0000926 ! has potential to develop into mesoderm relationship: BFO:0000050 UBERON:0000307 ! part of blastula relationship: RO:0002387 UBERON:0000926 ! has potential to develop into mesoderm property_value: skos:prefLabel "presumptive mesoderm" xsd:string [Term] id: UBERON:0006606 name: mandibular symphysis def: "A cartilaginous joint that connects left and right mandibles/dentary bones. Mandibular symphysis is unpaired[TAO,modified]." [TAO:wd, Wikipedia:Symphysis_menti, ZFA:0005488] subset: pheno_slim subset: vertebrate_core synonym: "dentary symphysis" EXACT [TAO:0001851] synonym: "inter-dentary joint" EXACT [TAO:0001851] synonym: "inter-mandibular joint" EXACT [TAO:0001851] synonym: "mental symphysis" RELATED [Wikipedia:Symphysis_menti] synonym: "symphysis mandibulae" RELATED OMO:0003011 [Wikipedia:Symphysis_menti] synonym: "symphysis menti" EXACT [MA:0001490] xref: AAO:0000277 xref: FMA:75779 xref: MA:0001490 xref: TAO:0001851 xref: Wikipedia:Symphysis_menti xref: ZFA:0005488 is_a: UBERON:0002216 {source="FMA"} ! symphysis intersection_of: UBERON:0002213 ! cartilaginous joint intersection_of: RO:0002176 UBERON:0004742 {cardinality="2"} ! connects dentary relationship: BFO:0000050 UBERON:0001710 ! part of lower jaw region relationship: RO:0002176 UBERON:0004742 ! connects dentary property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/6/64/Gray176.png" xsd:anyURI property_value: IAO:0000116 "this is placed as part of lower jaw region, as in this ontology the skeleton does not include joints" xsd:string property_value: skos:prefLabel "mandibular symphysis" xsd:string [Term] id: UBERON:0006614 name: aponeurosis def: "A sheet of extracellular matrix." [AEO:0000092, Wikipedia:Aponeurosis] synonym: "aponeuroses" RELATED OMO:0003004 [Wikipedia:Aponeurosis] synonym: "aponeurotic" RELATED [Wikipedia:Aponeurosis] xref: AEO:0000092 xref: EHDAA2:0003092 xref: FMA:9722 xref: NCIT:C32133 xref: SCTID:331712004 xref: UMLS:C0225205 {source="ncithesaurus:Aponeurosis"} xref: Wikipedia:Aponeurosis xref: ZFA:0005652 is_a: BFO:0000002 is_a: UBERON:0000158 {source="FMA"} ! membranous layer relationship: BFO:0000050 UBERON:0001630 {source="FMA"} ! part of muscle organ relationship: BFO:0000051 CL:0000327 {source="AEO"} ! has part extracellular matrix secreting cell property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/e/e6/Aponeurosis.png" xsd:anyURI [Term] id: UBERON:0006615 name: venous sinus def: "A large vein or channel for the circulation of venous blood." [http://medical-dictionary.thefreedictionary.com/venous+sinus] subset: pheno_slim synonym: "blood sinus" RELATED [ZFA:0007072] xref: MA:0000070 xref: NCIT:C12877 xref: SCTID:341586007 xref: UMLS:C0226504 {source="ncithesaurus:Venous_Sinus"} xref: ZFA:0007072 is_a: UBERON:0003920 ! venous blood vessel property_value: IAO:0000116 "check if it is valid to group ZFA class here." xsd:string [Term] id: UBERON:0006616 name: right external ear def: "An external ear that is in the right side of a multicellular organism." [OBOL:automatic] subset: pheno_slim synonym: "right auricular region" BROAD [FMA:53643] xref: EMAPA:37361 {source="MA:th"} xref: FMA:53643 xref: SCTID:368567003 is_a: UBERON:0001691 ! external ear intersection_of: UBERON:0001691 ! external ear intersection_of: BSPO:0000121 UBERON:0000468 ! multicellular organism relationship: BSPO:0000121 UBERON:0000468 ! multicellular organism [Term] id: UBERON:0006617 name: left external ear def: "An external ear that is in the left side of a multicellular organism." [OBOL:automatic] subset: pheno_slim synonym: "left auricular region" BROAD [FMA:53644] xref: EMAPA:37360 {source="MA:th"} xref: FMA:53644 xref: SCTID:368589004 is_a: UBERON:0001691 ! external ear intersection_of: UBERON:0001691 ! external ear intersection_of: BSPO:0000120 UBERON:0000468 ! multicellular organism relationship: BSPO:0000120 UBERON:0000468 ! multicellular organism [Term] id: UBERON:0006632 name: musculo-phrenic artery def: "An artery with its origin in the lateral terminal branch of the internal thoracic artery, with distribution to the diaphragm and the intercostal muscles, and with anastomoses to the branches of the pericardiacophrenic and inferior phrenic." [http://medical-dictionary.thefreedictionary.com/musculophrenic+artery] subset: human_reference_atlas synonym: "musculophrenic artery" EXACT [FMA:10645] xref: EMAPA:19215 xref: FMA:10645 xref: SCTID:244242003 xref: Wikipedia:Musculophrenic_artery is_a: UBERON:0002057 ! phrenic artery intersection_of: UBERON:0001637 ! artery intersection_of: RO:0002252 UBERON:0002456 ! connecting branch of internal thoracic artery intersection_of: RO:0020101 UBERON:0001103 ! vessel supplies blood to diaphragm relationship: RO:0002252 UBERON:0002456 ! connecting branch of internal thoracic artery property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0006642 name: muscle layer of oviduct def: "A muscle layer that is part of a fallopian tube." [OBOL:automatic] synonym: "muscle layer of fallopian tube" EXACT [FMA:18318] synonym: "muscle layer of oviduct" EXACT [FMA:18318] synonym: "muscle layer of uterine tube" EXACT [FMA:18318] synonym: "muscular coat of uterine tube" EXACT [FMA:18318] synonym: "muscular layer of uterine tube" EXACT [FMA:18318] synonym: "muscularis of uterine tube" EXACT [FMA:18318] synonym: "tunica muscularis (Tuba uterina)" EXACT [FMA:18318] synonym: "tunica muscularis tubae uterinae" EXACT OMO:0003011 [FMA:18318, FMA:TA] synonym: "uterine tubal muscularis" EXACT [FMA:18318] xref: EMAPA:29046 xref: FMA:18318 xref: SCTID:259488000 is_a: UBERON:0005156 ! reproductive structure is_a: UBERON:0006660 ! muscular coat intersection_of: UBERON:0006660 ! muscular coat intersection_of: BFO:0000050 UBERON:0003889 ! part of fallopian tube relationship: BFO:0000050 UBERON:0003889 ! part of fallopian tube [Term] id: UBERON:0006645 name: adventitia of epididymis def: "An adventitia that is part of a epididymis." [OBOL:automatic] synonym: "epididymis adventitia" EXACT [FMA:19136] xref: EMAPA:30443 xref: FMA:19136 is_a: UBERON:0005156 ! reproductive structure is_a: UBERON:0005742 ! adventitia intersection_of: UBERON:0005742 ! adventitia intersection_of: BFO:0000050 UBERON:0001301 ! part of epididymis relationship: BFO:0000050 UBERON:0001301 ! part of epididymis [Term] id: UBERON:0006646 name: muscle layer of epididymis def: "A muscle layer that is part of a epididymis." [OBOL:automatic] xref: EMAPA:30747 xref: FMA:19149 is_a: UBERON:0005156 ! reproductive structure is_a: UBERON:0006660 ! muscular coat intersection_of: UBERON:0006660 ! muscular coat intersection_of: BFO:0000050 UBERON:0001301 ! part of epididymis relationship: BFO:0000050 UBERON:0001301 ! part of epididymis [Term] id: UBERON:0006647 name: adventitia of ductus deferens def: "An adventitia that is part of a vas deferens." [OBOL:automatic] synonym: "adventitia of deferent duct" EXACT [FMA:19238] synonym: "adventitia of ductus deferens" EXACT [FMA:19238] synonym: "adventitia of vas deferens" EXACT [FMA:19238] synonym: "deferent ductal adventitia" EXACT [FMA:19238] synonym: "tunica adventitia (ductus deferens)" EXACT [FMA:19238] synonym: "tunica adventitia ductus deferentis" EXACT OMO:0003011 [FMA:19238, FMA:TA] xref: EMAPA:29767 xref: FMA:19238 xref: SCTID:299803005 is_a: UBERON:0005156 ! reproductive structure is_a: UBERON:0005742 ! adventitia intersection_of: UBERON:0005742 ! adventitia intersection_of: BFO:0000050 UBERON:0001000 ! part of vas deferens relationship: BFO:0000050 UBERON:0001000 ! part of vas deferens [Term] id: UBERON:0006648 name: adventitia of seminal vesicle def: "An adventitia that is part of a seminal vesicle." [OBOL:automatic] synonym: "adventitia of seminal gland" EXACT [FMA:19403] synonym: "seminal vesicle adventitia" EXACT [FMA:19403] synonym: "tunica adventitia (vesicula seminalis)" EXACT [FMA:19403] synonym: "tunica adventitia glandulae vesiculosae" EXACT OMO:0003011 [FMA:19403, FMA:TA] xref: EMAPA:29775 xref: FMA:19403 xref: SCTID:252406002 is_a: UBERON:0005156 ! reproductive structure is_a: UBERON:0005742 ! adventitia intersection_of: UBERON:0005742 ! adventitia intersection_of: BFO:0000050 UBERON:0000998 ! part of seminal vesicle relationship: BFO:0000050 UBERON:0000998 ! part of seminal vesicle [Term] id: UBERON:0006652 name: muscular layer of vagina synonym: "muscular coat of vagina" EXACT [FMA:19976] synonym: "tunica muscularis vaginae" EXACT OMO:0003011 [FMA:19976, FMA:TA] synonym: "vaginal muscularis" EXACT [] xref: EMAPA:30997 xref: FMA:19976 xref: SCTID:253069005 is_a: UBERON:0005156 ! reproductive structure is_a: UBERON:0006660 ! muscular coat intersection_of: UBERON:0006660 ! muscular coat intersection_of: BFO:0000050 UBERON:0000996 ! part of vagina relationship: BFO:0000050 UBERON:0000996 ! part of vagina [Term] id: UBERON:0006653 name: glans clitoris def: "Erectile tissue at the end of the clitoris, which is continuous with the intermediate part of the vestibulovaginal bulbs[BTO]. The clitoral glans (glans clitoridis) is an external portion of the clitoris[WP]." [BTO:0003117, Wikipedia:Clitoral_glans] synonym: "clitoris glans" EXACT [FMA:19999] synonym: "glans clitoridis" RELATED [Wikipedia:Clitoral_glans] synonym: "glans clitoris" RELATED [Wikipedia:Clitoral_glans] synonym: "glans of clitoris" EXACT [FMA:19999] xref: BTO:0003117 xref: EMAPA:30829 xref: FMA:19999 xref: NCIT:C32681 xref: SCTID:362241002 xref: UMLS:C0227769 {source="ncithesaurus:Glans_Clitoris"} xref: Wikipedia:Clitoral_glans is_a: UBERON:0008324 ! erectile tissue is_a: UBERON:0035651 ! glans intersection_of: UBERON:0035651 ! glans intersection_of: BFO:0000050 UBERON:0002411 ! part of clitoris relationship: BFO:0000050 UBERON:0002411 ! part of clitoris relationship: RO:0002202 UBERON:0013240 {source="cjm"} ! develops from future glans clitoris property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/8/8c/Clitoris_inner_anatomy.gif" xsd:anyURI [Term] id: UBERON:0006657 name: glenoid fossa def: "Anatomical cavity for the proximal articular surface of the proximal limb or fin element with the scapulocoracoid or equivalent structure." [PHENOSCAPE:ad] subset: pheno_slim synonym: "cavitas glenoidalis" RELATED OMO:0003011 [Wikipedia:Glenoid_cavity] synonym: "cavitas glenoidalis scapulae" EXACT OMO:0003011 [FMA:23275, FMA:TA] synonym: "cavitus glenoidalis" EXACT [FMA:23275] synonym: "glenoid cavity" EXACT [FMA:23275] synonym: "glenoid cavity" RELATED [AAO:0000749] synonym: "glenoid cavity of scapula" EXACT [FMA:23275] synonym: "glenoid facet" EXACT [] xref: AAO:0000749 xref: EMAPA:25122 xref: FMA:23275 xref: MESH:D061165 {sssom:mapping_justification="https://w3id.org/semapv/vocab/LexicalMatching"} xref: NCIT:C32682 xref: SCTID:181914008 xref: UMLS:C1261046 {source="ncithesaurus:Glenoid_Fossa"} xref: Wikipedia:Glenoid_cavity is_a: UBERON:0004704 ! bone fossa relationship: BFO:0000050 UBERON:0004753 ! part of scapulocoracoid relationship: RO:0002220 UBERON:0006849 ! adjacent to scapula property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/e/ec/Gray328.png" xsd:anyURI [Term] id: UBERON:0006658 name: interphalangeal joint def: "A joint that connects one phalanx to another along a proximodistal axis." [http://orcid.org/0000-0002-6601-2165] subset: pheno_slim synonym: "inter-phalangeal joint" EXACT [FMA:42765] synonym: "inter-phalanx joint" EXACT [] xref: EMAPA:37884 {source="MA:th"} xref: FMA:42765 xref: galen:InterphalangealJoint xref: NCIT:C101527 is_a: UBERON:0003841 ! autopod joint is_a: UBERON:0011139 ! synovial limb joint intersection_of: UBERON:0000982 ! skeletal joint intersection_of: RO:0002176 UBERON:0003221 {cardinality="2"} ! connects phalanx relationship: BFO:0000050 UBERON:0002544 {source="cjm"} ! part of digit relationship: RO:0002176 UBERON:0003221 ! connects phalanx [Term] id: UBERON:0006660 name: muscular coat def: "A region of muscle in many organs in the vertebrate body, adjacent to the submucosa membrane. It is responsible for gut movement such as peristalsis." [Wikipedia:Muscular_layer] synonym: "muscular coat" RELATED [Wikipedia:Muscularis_externa] synonym: "muscular layer" EXACT [OBOL:automatic] synonym: "muscularis" RELATED [] synonym: "muscularis externa" RELATED [BTO:0004838] synonym: "muscularis layer" EXACT [FMA:45634] synonym: "muscularis propria" RELATED [Wikipedia:Muscularis_externa] synonym: "transverse muscular fibers" RELATED [Wikipedia:Muscularis_externa] synonym: "tunica externa" RELATED [BTO:0004838] synonym: "tunica muscularis" EXACT OMO:0003011 [BTO:0004838] synonym: "tunica muscularis" RELATED [Wikipedia:Muscularis_externa] xref: BTO:0004838 xref: SCTID:86915006 xref: UMLS:C0225358 {source="ncithesaurus:Muscle_Layer"} xref: Wikipedia:Muscular_layer is_a: UBERON:0018260 ! layer of muscle tissue relationship: RO:0002162 NCBITaxon:7742 ! in taxon Vertebrata relationship: RO:0002220 UBERON:0000009 ! adjacent to submucosa property_value: IAO:0000116 "currently this class conflates a generic layer of muscle and a specific layer found lining the digestive tract (the muscularis externa), typically composed of circular and longitudinal layers (although this varies)" xsd:string property_value: skos:prefLabel "muscular coat" xsd:string [Term] id: UBERON:0006661 name: epicranial aponeurosis def: "The galea aponeurotica (epicranial aponeurosis, aponeurosis epicranialis) is a tough layer of dense fibrous tissue which covers the upper part of the cranium; behind, it is attached, in the interval between its union with the Occipitales, to the external occipital protuberance and highest nuchal lines of the occipital bone; in front, it forms a short and narrow prolongation between its union with the Frontales. On either side it gives origin to the Auriculares anterior and superior; in this situation it loses its aponeurotic character, and is continued over the temporal fascia to the zygomatic arch as a layer of laminated areolar tissue. It is closely connected to the integument by the firm, dense, fibro-fatty layer which forms the superficial fascia of the scalp: it is attached to the pericranium by loose cellular tissue, which allows the aponeurosis, carrying with it the integument to move through a considerable distance." [Wikipedia:Galea_aponeurotica] synonym: "aponeurosis epicranialis" EXACT OMO:0003011 [FMA:46768, FMA:TA] synonym: "aponeurosis of epicranius" EXACT [FMA:46768] synonym: "cranial aponeurosis" RELATED [Wikipedia:Galea_aponeurotica] synonym: "epicranial aponeurosis" EXACT [FMA:46768] synonym: "epicranial aponeurosis" RELATED [Wikipedia:Galea_aponeurotica] synonym: "epicranius aponeurosis" EXACT [FMA:46768] synonym: "galea aponeurosis" RELATED [Wikipedia:Galea_aponeurotica] synonym: "galea aponeurotica" EXACT [FMA:46768] synonym: "galea aponeurotica; aponeurosis epicranialis" RELATED OMO:0003011 [Wikipedia:Galea_aponeurotica] synonym: "galeal aponeurosis" RELATED [Wikipedia:Galea_aponeurotica] xref: EMAPA:19210 xref: FMA:46768 xref: SCTID:368677009 xref: Wikipedia:Galea_aponeurotica is_a: UBERON:0006614 ! aponeurosis relationship: BFO:0000050 UBERON:0000403 {source="FMA"} ! part of scalp property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/f/fa/Gray378.png" xsd:anyURI [Term] id: UBERON:0006668 name: carotid canal def: "On the interior surface of the temporal bone, behind the rough surface of the apex, is the large circular aperture of the carotid canal, which ascends at first vertically, and then, making a bend, runs horizontally forward and medialward. It transmits into the cranium, the internal carotid artery, and the carotid plexus of nerves. Sympathetics to the head also pass through the carotid canal. They have several motor functions: raise the eyelid (superior tarsal muscle), dilate pupil, innervate sweat glands of face and scalp and constricts blood vessels in head[WP]." [Wikipedia:Carotid_canal] synonym: "canalis caroticus" RELATED OMO:0003011 [Wikipedia:Carotid_canal] xref: EMAPA:18707 xref: FMA:55805 xref: Wikipedia:Carotid_canal is_a: UBERON:0013685 ! foramen of skull intersection_of: UBERON:0013685 ! foramen of skull intersection_of: RO:0002570 UBERON:0001532 ! conduit for internal carotid artery relationship: BFO:0000050 UBERON:0001678 ! part of temporal bone relationship: RO:0002570 UBERON:0001532 ! conduit for internal carotid artery property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/4/4c/Gray141.png" xsd:anyURI property_value: skos:prefLabel "carotid canal" xsd:string [Term] id: UBERON:0006670 name: central tendon of diaphragm def: "The three-lobed cloverleaf-shaped aponeurosis situated at the center of the diaphragm; the central tendon is fused with the fibrous pericardium that provides attachment for the muscle fibers." [MGI:csmith, MP:0012061] subset: pheno_slim synonym: "central tendon" EXACT [FMA:58279] synonym: "centrum tendineum" EXACT [FMA:58279] synonym: "centrum tendineum diaphragmatis" EXACT OMO:0003011 [FMA:58279, FMA:TA] xref: EMAPA:17702 xref: FMA:58279 xref: NCIT:C34119 xref: SCTID:244943002 xref: UMLS:C0230162 {source="ncithesaurus:Central_Tendon_of_the_Diaphragm"} xref: VHOG:0001399 xref: Wikipedia:Central_tendon_of_diaphragm is_a: UBERON:0000043 ! tendon is_a: UBERON:0003570 ! respiratory system connective tissue is_a: UBERON:0003837 ! thoracic segment connective tissue relationship: BFO:0000050 UBERON:0001103 {source="VHOG"} ! part of diaphragm relationship: RO:0002371 UBERON:0002359 ! attached to fibrous pericardium relationship: RO:0002495 UBERON:0006239 {evidence="definitional"} ! immediate transformation of future central tendon property_value: skos:prefLabel "central tendon of diaphragm" xsd:string [Term] id: UBERON:0006675 name: venous valve def: "A valve that is part of a vein." [OBOL:automatic] synonym: "valve of vein" EXACT [FMA:68095] xref: FMA:68095 is_a: UBERON:0003978 ! valve intersection_of: UBERON:0003978 ! valve intersection_of: BFO:0000050 UBERON:0001638 ! part of vein relationship: BFO:0000050 UBERON:0001638 ! part of vein [Term] id: UBERON:0006676 name: muscularis mucosa def: "A thin layer of smooth muscle found in most parts of the gastrointestinal tract, located outside the lamina propria mucosae and separating it from the submucosa[WP]." [Wikipedia:Muscularis_mucosae] synonym: "gut muscularis" EXACT [EMAPA:35385] synonym: "lamina muscularis mucosa" RELATED [BTO:0004839] synonym: "laminar muscularis mucosa" RELATED [Wikipedia:Muscularis_mucosae] synonym: "muscularis mucosae" EXACT [FMA:68413] xref: BTO:0004839 xref: EMAPA:35385 xref: FMA:68413 xref: galen:MuscularisMucosae xref: NCIT:C33149 xref: SCTID:370140002 xref: UMLS:C0225357 {source="ncithesaurus:Muscularis_Mucosa"} xref: Wikipedia:Muscularis_mucosae is_a: UBERON:0004226 ! gastrointestinal system smooth muscle relationship: BFO:0000050 UBERON:0004786 ! part of gastrointestinal system mucosa relationship: BSPO:0001107 UBERON:0000030 ! lamina propria property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/5/54/Gray1058.png" xsd:anyURI [Term] id: UBERON:0006677 name: surface of epithelium def: "An anatomical boundary that adjacent_to a epithelium." [OBOL:automatic] synonym: "epithelium surface" EXACT [FMA:70997] xref: FMA:70997 is_a: UBERON:0036215 ! anatomical surface region intersection_of: UBERON:0036215 ! anatomical surface region intersection_of: RO:0002007 UBERON:0000483 ! bounding layer of epithelium relationship: RO:0002007 UBERON:0000483 ! bounding layer of epithelium property_value: skos:prefLabel "surface of epithelium" xsd:string [Term] id: UBERON:0006682 name: hypoglossal canal def: "The hypoglossal canal is a bony canal in the occipital bone of the skull." [Wikipedia:Hypoglossal_canal] synonym: "anterior condylar canal" RELATED [EMAPA:19012] synonym: "canalis nervi hypoglossi" RELATED OMO:0003011 [Wikipedia:Hypoglossal_canal] synonym: "hyperglossal canal" RELATED [Wikipedia:Hypoglossal_canal] xref: EMAPA:19012 xref: FMA:75370 xref: SCTID:139380001 xref: Wikipedia:Hypoglossal_canal is_a: UBERON:0013685 ! foramen of skull intersection_of: UBERON:0004111 ! anatomical conduit intersection_of: RO:0002570 UBERON:0001650 ! conduit for hypoglossal nerve relationship: BFO:0000050 UBERON:0001676 ! part of occipital bone relationship: RO:0002570 UBERON:0001650 ! conduit for hypoglossal nerve property_value: skos:prefLabel "hypoglossal canal" xsd:string [Term] id: UBERON:0006686 name: spinal vein def: "A vein that is part of a vertebral column." [OBOL:automatic] synonym: "spinal branch" RELATED [FMA:76735] synonym: "vena spinalis" EXACT OMO:0003011 [FMA:76735, FMA:TA] xref: EMAPA:18255 xref: FMA:76735 xref: MA:0002108 xref: SCTID:181376008 xref: Wikipedia:Spinal_veins is_a: UBERON:0001638 ! vein intersection_of: UBERON:0001638 ! vein intersection_of: BFO:0000050 UBERON:0001130 ! part of vertebral column relationship: BFO:0000050 UBERON:0001130 ! part of vertebral column property_value: skos:prefLabel "spinal vein" xsd:string [Term] id: UBERON:0006692 name: vertebral canal def: "A conduit enclosed within the vertebral foramen of the vertebrae through which the spinal cord passes." [http://orcid.org/0000-0002-6601-2165, Wikipedia:Spinal_canal] subset: pheno_slim synonym: "c. vertebralis" RELATED OMO:0003011 [Wikipedia:Spinal_canal] synonym: "foramen vertebrale" RELATED [AAO:0000693] synonym: "neural canal" RELATED [AAO:0000693] synonym: "spinal canal" RELATED [AAO:0000693] synonym: "spinal cavity" RELATED [Wikipedia:Spinal_canal] synonym: "vertebral canal" RELATED [Wikipedia:Spinal_canal] xref: AAO:0000693 xref: FMA:9680 xref: GAID:242 xref: MESH:D013115 {sssom:mapping_justification="https://w3id.org/semapv/vocab/LexicalMatching"} xref: NCIT:C33869 xref: NCIT:C34221 xref: SCTID:361746009 xref: UMLS:C0037922 {source="ncithesaurus:Vertebral_Canal"} xref: UMLS:C1522467 {source="ncithesaurus:Neural_Canal"} xref: Wikipedia:Spinal_canal is_a: UBERON:0004111 ! anatomical conduit intersection_of: UBERON:0004111 ! anatomical conduit intersection_of: RO:0002570 UBERON:0002240 ! conduit for spinal cord intersection_of: RO:0002571 UBERON:0001130 ! lumen of vertebral column relationship: RO:0002221 UBERON:0002240 ! surrounds spinal cord relationship: RO:0002570 UBERON:0002240 ! conduit for spinal cord relationship: RO:0002571 UBERON:0001130 ! lumen of vertebral column property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/3/30/Gray82.png" xsd:anyURI property_value: IAO:0000116 "TODO - check neural vs vertebral canal; embryonic vs adult?" xsd:string [Term] id: UBERON:0006694 name: cerebellum vasculature def: "A vasculature that is part of a cerebellum." [OBOL:automatic] xref: FMA:268519 is_a: UBERON:0006876 ! vasculature of organ is_a: UBERON:0036303 ! vasculature of central nervous system intersection_of: UBERON:0002049 ! vasculature intersection_of: BFO:0000050 UBERON:0002037 ! part of cerebellum relationship: BFO:0000050 UBERON:0002037 ! part of cerebellum property_value: skos:prefLabel "cerebellum vasculature" xsd:string [Term] id: UBERON:0006716 name: mesopodium region def: "The third segment of the limb, including either the wrist segment (carpus) or the ankle segment (tarsus)." [https://orcid.org/0000-0002-6601-2165, MA:th, Wikipedia:Carpus_and_tarsus_of_land_vertebrates] synonym: "carpus/tarsus" EXACT [] synonym: "mesopod" RELATED [] synonym: "mesopodial limb segment" EXACT [MA:th] synonym: "mesopodial segment" EXACT [] xref: Wikipedia:Carpus_and_tarsus_of_land_vertebrates is_a: UBERON:0002529 ! limb segment intersection_of: UBERON:0002529 ! limb segment intersection_of: distally_connected_to UBERON:0009877 ! metapodium region intersection_of: proximally_connected_to UBERON:0002471 ! zeugopod relationship: BFO:0000050 UBERON:0002470 {source="MA:th"} ! part of autopod region relationship: distally_connected_to UBERON:0009877 ! metapodium region relationship: proximally_connected_to UBERON:0002471 ! zeugopod relationship: RO:0002551 UBERON:0009878 ! has skeleton mesopodial skeleton [Term] id: UBERON:0006717 name: autopodial skeleton def: "The collection of all skeletal elements in an autopodium region." [https://orcid.org/0000-0002-6601-2165] synonym: "autopod skeleton" EXACT [https://orcid.org/0000-0002-6601-2165] synonym: "autopodial skeleton" EXACT [VSAO:0005019] synonym: "autopodium" RELATED [VSAO:0005019, VSAO:NI] synonym: "skeletal parts of autopod" EXACT [https://orcid.org/0000-0002-6601-2165] synonym: "skeleton of autopod" EXACT [https://orcid.org/0000-0002-6601-2165] xref: VSAO:0005019 is_a: UBERON:0010712 ! limb skeleton subdivision intersection_of: UBERON:0010912 ! subdivision of skeleton intersection_of: RO:0002576 UBERON:0002470 ! skeleton of autopod region relationship: BFO:0000050 UBERON:0004381 ! part of skeleton of limb relationship: proximally_connected_to UBERON:0011584 ! zeugopodial skeleton relationship: RO:0002576 UBERON:0002470 ! skeleton of autopod region [Term] id: UBERON:0006723 name: cochlear modiolus def: "The central cone shaped core of spongy bone about which turns the spiral canal." [ISBN:0-683-40008-8, MGI:anna, MP:0003309] subset: organ_slim subset: pheno_slim synonym: "cochlea modiolus" EXACT [FMA:61278] synonym: "columella cochleae" RELATED [BTO:0001693] synonym: "modiolus" BROAD [MA:0001182] synonym: "modiolus cochleae" EXACT OMO:0003011 [FMA:61278, FMA:TA] synonym: "modiolus of cochlea" EXACT [FMA:61278] xref: BTO:0001693 xref: EMAPA:35575 xref: FMA:61278 xref: MA:0001182 xref: NCIT:C33135 xref: SCTID:361314007 xref: UMLS:C0229503 {source="ncithesaurus:Modiolus"} xref: Wikipedia:Modiolus_(cochlea) is_a: UBERON:0005913 ! zone of bone organ relationship: BFO:0000050 UBERON:0007223 {source="MA"} ! part of osseus cochlea relationship: RO:0002433 UBERON:0001844 ! contributes to morphology of cochlea property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/1/16/Gray921.png" xsd:anyURI property_value: skos:prefLabel "cochlear modiolus" xsd:string [Term] id: UBERON:0006725 name: spiral ligament def: "A spiral thickening of the fibrous lining of the cochlear wall. Spiral ligament secures the membranous cochlear duct to the bony spiral canal of the cochlea. Its spiral ligament fibrocytes function in conjunction with the stria vascularis to mediate cochlear ion homeostasis." [https://github.com/obophenotype/mouse-anatomy-ontology/issues/71, Wikipedia:Spiral_ligament] subset: pheno_slim synonym: "ligamentum spirale ductus cochlearis" EXACT OMO:0003011 [Wikipedia:Spiral_ligament] synonym: "spiral cochlear ligament" EXACT OMO:0003011 [] synonym: "spiral ligament of cochlea" EXACT [BIRNLEX:2524] synonym: "spiral ligament of cochlear duct" EXACT [FMA:77834] xref: BIRNLEX:2524 xref: EMAPA:35798 xref: FMA:77834 xref: MA:0001192 xref: MESH:D055493 xref: SCTID:279840005 xref: UMLS:C0229477 xref: Wikipedia:Spiral_ligament is_a: UBERON:0008845 ! nonskeletal ligament relationship: BFO:0000050 UBERON:0001855 ! part of cochlear duct of membranous labyrinth relationship: BFO:0000051 CL:0002665 ! has part otic fibrocyte relationship: RO:0002371 UBERON:0006106 {source="MESH-def"} ! attached to cochlear canal [Term] id: UBERON:0006756 name: median lingual swelling def: "During the third week of embryological development there appears, immediately behind the ventral ends of the two halves of the mandibular arch, a rounded swelling named the tuberculum impar, which was described by His as undergoing enlargement to form the buccal part of the tongue. More recent researches, however, show that this part of the tongue is mainly, if not entirely, developed from a pair of lateral swellings which rise from the inner surface of the mandibular arch and meet in the middle line. The site of their meeting remains post-embryonically as the median sulcus of the tongue. The tuberculum impar is said to form the central part of the tongue immediately in front of the foramen cecum, but Hammar insists that it is purely a transitory structure and forms no part of the adult tongue[WP, Gray's]." [Wikipedia:Tuberculum_impar] comment: The thyroid initially develops caudal to the tuberculum impar . This embryonic swelling arises from the first pharyngeal arch and occurs midline on the floor of the developing pharynx, eventually helping form the tongue as the 2 lateral lingual swellings overgrow it. [http://emedicine.medscape.com/article/845125-overview] synonym: "median lingual swelling" EXACT [EHDAA2:0001081] synonym: "median tongue bud" EXACT [http://emedicine.medscape.com/article/845125-overview] synonym: "tuberculum impar" EXACT [] synonym: "tuberculum linguale mediale" EXACT [Wikipedia:Tuberculum_impar] xref: EHDAA2:0001081 xref: EMAPA:17187 xref: FMA:312476 xref: SCTID:308821003 xref: VHOG:0000730 xref: Wikipedia:Tuberculum_impar is_a: BFO:0000002 is_a: UBERON:0002050 ! embryonic structure relationship: BFO:0000050 UBERON:0006260 {source="EHDAA2"} ! part of lingual swellings relationship: RO:0002202 UBERON:0004362 ! develops from pharyngeal arch 1 property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/5/5c/Gray979.png" xsd:anyURI property_value: skos:prefLabel "median lingual swelling" xsd:string [Term] id: UBERON:0006757 name: lateral lingual swelling def: "During the third week there appears, immediately behind the ventral ends of the two halves of the mandibular arch, a rounded swelling named the tuberculum impar, which was described by His as undergoing enlargement to form the buccal part of the tongue. More recent researches, however, show that this part of the tongue is mainly, if not entirely, developed from a pair of lateral swellings (or distal tongue bud) which rise from the inner surface of the mandibular arch and meet in the middle line." [Wikipedia:Lateral_lingual_swelling] synonym: "lateral lingual prominence" RELATED [] synonym: "lateral swellings" RELATED [Wikipedia:Lateral_lingual_swelling] synonym: "tuberculum laterale" RELATED [Wikipedia:Lateral_lingual_swelling] synonym: "tuberculum linguale laterale" RELATED OMO:0003011 [Wikipedia:Lateral_lingual_swelling] xref: EHDAA2:0000911 xref: EMAPA:17189 xref: FMA:313628 xref: VHOG:0000731 xref: Wikipedia:Lateral_lingual_swelling is_a: BFO:0000002 is_a: UBERON:0002050 ! embryonic structure relationship: BFO:0000050 UBERON:0006260 ! part of lingual swellings relationship: RO:0002202 UBERON:0004362 ! develops from pharyngeal arch 1 property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/5/5c/Gray979.png" xsd:anyURI property_value: skos:prefLabel "lateral lingual swelling" xsd:string [Term] id: UBERON:0006761 name: corneo-scleral junction def: "The edge of the cornea where it joins the sclera; the limbus is a common site for the occurrence of corneal epithelial neoplasm." [MP:0013477] comment: This location has parts such as blood vessels etc. See PMC2868485, http://www.ncbi.nlm.nih.gov/pubmed/2695343 subset: efo_slim subset: human_reference_atlas subset: pheno_slim subset: vertebrate_core synonym: "cornea limbus" EXACT [] synonym: "corneal limbus" EXACT [FMA:58342, GAID:896] synonym: "corneal-scleral limbus" EXACT [PMID:17051547] synonym: "corneoscleral junction" EXACT [GAID:896] synonym: "limbus corneae" EXACT OMO:0003011 [Wikipedia:Corneal_limbus] synonym: "limbus corneae" RELATED OMO:0003011 [Wikipedia:Corneal_limbus] synonym: "sclerocorneal junction" EXACT [FMA:58342] synonym: "sclerocorneal limbus" EXACT [GAID:896] xref: EFO:0001403 xref: EMAPA:37835 {source="MA:th"} xref: FMA:58342 xref: GAID:896 xref: MESH:D016850 xref: SCTID:63716004 xref: Wikipedia:Corneal_limbus xref: ZFA:0005570 is_a: UBERON:0007651 ! anatomical junction intersection_of: UBERON:0007651 ! anatomical junction intersection_of: RO:0002176 UBERON:0000964 ! connects cornea intersection_of: RO:0002176 UBERON:0001773 ! connects sclera relationship: BFO:0000050 UBERON:0000019 ! part of camera-type eye relationship: RO:0002176 UBERON:0000964 ! connects cornea relationship: RO:0002176 UBERON:0001773 ! connects sclera property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/3/3d/Limbus.png" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "corneo-scleral junction" xsd:string [Term] id: UBERON:0006763 name: epithelium of conjunctiva def: "Layer of nonkeratinized squamous epithelium lining the conjunctiva, overlying scleral tissue." [http://orcid.org/0000-0002-6601-2165] subset: efo_slim subset: human_reference_atlas subset: pheno_slim synonym: "conjunctiva epithelium" EXACT [FMA:62131] synonym: "conjunctival epithelium" EXACT [BTO:0005131] xref: BTO:0005131 xref: EFO:0001916 xref: FMA:62131 xref: NCIT:C32365 xref: UMLS:C1179037 {source="ncithesaurus:Conjunctival_Epithelium"} is_a: UBERON:0010304 {source="FMA"} ! non-keratinized stratified squamous epithelium is_a: UBERON:0015808 ! eye epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: BFO:0000050 UBERON:0001811 ! part of conjunctiva relationship: BFO:0000050 UBERON:0001811 {source="BTO"} ! part of conjunctiva property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0006799 name: glandular epithelium def: "An epithelium that is composed primarily of secretory cells." [http://orcid.org/0000-0002-6601-2165] xref: BTO:0002991 xref: NCIT:C43370 xref: NCIT:C45715 xref: UMLS:C0682578 {source="ncithesaurus:Glandular_Epithelium"} xref: UMLS:C1708242 {source="ncithesaurus:Glandular_Epithelial_Tissue"} is_a: UBERON:0000483 ! epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: RO:0002473 CL:0000150 ! composed primarily of glandular secretory epithelial cell relationship: RO:0002473 CL:0000150 ! composed primarily of glandular secretory epithelial cell property_value: IAO:0000116 "consider splitting epithelium from epithelial tissue" xsd:string property_value: skos:prefLabel "glandular epithelium" xsd:string [Term] id: UBERON:0006813 name: nasal skeleton def: "Structural framework that provides support to the nasal sacs and ducts." [AAO:0000320] subset: pheno_slim synonym: "skeleton of nose" EXACT [FMA:60116] xref: AAO:0000320 xref: FMA:60116 xref: SCTID:281486007 is_a: UBERON:0000075 {source="FMA"} ! subdivision of skeletal system is_a: UBERON:0010912 ! subdivision of skeleton intersection_of: UBERON:0010912 ! subdivision of skeleton intersection_of: RO:0002576 UBERON:0000004 ! skeleton of nose relationship: BFO:0000050 UBERON:0003113 ! part of dermatocranium relationship: RO:0002576 UBERON:0000004 ! skeleton of nose property_value: skos:prefLabel "nasal skeleton" xsd:string [Term] id: UBERON:0006815 name: areolar connective tissue def: "Loose connective tissue located at the outer and inner layers of organs. Examples: submucosal connective tissue, tunica adventitia of artery, papillary dermis, superficial fascia of dorsum of hand." [FMA:63897] synonym: "areolar tissue" RELATED [] synonym: "loose areolar connective tissue" EXACT [FMA:63897] synonym: "loose connective tissue" RELATED [AAO:0000027] xref: AAO:0000027 xref: FMA:63897 xref: SCTID:68477002 is_a: BFO:0000002 is_a: UBERON:0011825 {source="FMA"} ! loose connective tissue relationship: BFO:0000050 UBERON:0000030 ! part of lamina propria relationship: BFO:0000051 CL:1000303 {source="FMA"} ! has part fibroblast of areolar connective tissue relationship: protects UBERON:0000062 ! organ property_value: skos:prefLabel "areolar connective tissue" xsd:string [Term] id: UBERON:0006828 name: trabecula carnea of atrium def: "The supporting bundles of muscular fibers lining the walls of the atria[MP]." [MP:0010581] is_a: UBERON:0002511 ! trabecula carnea intersection_of: UBERON:0002511 ! trabecula carnea intersection_of: BFO:0000050 UBERON:0002081 ! part of cardiac atrium relationship: BFO:0000050 UBERON:0002081 ! part of cardiac atrium property_value: IAO:0000116 "Not present in any AO. Note that WP states that trabecular carnea are ventricular and 'They should not be confused with the pectinate muscles, which are present in the right and left atria only'" xsd:string [Term] id: UBERON:0006832 name: lumen of open tracheal system trachea def: "An anatomical space that surrounded_by a open tracheal system trachea." [OBOL:automatic] synonym: "tracheal lumen" BROAD SENSU [FBbt:00007410] xref: FBbt:00007410 {sssom:mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"} is_a: UBERON:0000464 ! anatomical space intersection_of: UBERON:0000464 ! anatomical space intersection_of: RO:0002572 UBERON:0003127 ! luminal space of open tracheal system trachea relationship: RO:0002572 UBERON:0003127 ! luminal space of open tracheal system trachea [Term] id: UBERON:0006833 name: lumen of trachea def: "An anatomical space that surrounded_by a trachea." [OBOL:automatic] synonym: "lumen of cartilaginous trachea" EXACT [OBOL:automatic] synonym: "tracheal lumen" EXACT [FMA:7469] xref: FMA:7469 xref: SCTID:197486000 is_a: UBERON:0000464 ! anatomical space intersection_of: UBERON:0000464 ! anatomical space intersection_of: RO:0002572 UBERON:0003126 ! luminal space of trachea relationship: RO:0002572 UBERON:0003126 ! luminal space of trachea property_value: skos:prefLabel "lumen of trachea" xsd:string [Term] id: UBERON:0006834 name: uterus or analog def: "A subdivision of a the reproductive tract in a female organism that is the site of embryo development." [http://orcid.org/0000-0002-6601-2165] subset: grouping_class synonym: "uterus" BROAD SENSU [FBbt:00004924] xref: FBbt:00004924 {sssom:mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"} xref: TADS:0000421 xref: WBbt:0006760 is_a: UBERON:0005156 ! reproductive structure is_a: UBERON:0013522 ! subdivision of tube intersection_of: UBERON:0013522 ! subdivision of tube intersection_of: site_of GO:0009790 ! embryo development relationship: BFO:0000050 UBERON:0000474 ! part of female reproductive system relationship: site_of GO:0009790 ! embryo development property_value: skos:prefLabel "uterus or analog" xsd:string [Term] id: UBERON:0006841 name: central vein of liver def: "Vein that is central to a lobule in the liver." [ZFA:0005168] subset: human_reference_atlas subset: vertebrate_core synonym: "central vein" BROAD [ZFA:0005168] synonym: "terminal branch of hepatic vein" EXACT [FMA:17544] synonym: "terminal hepatic venule" EXACT [FMA:17544] synonym: "vena centralis (hepar)" EXACT [FMA:17544] xref: FMA:17544 xref: NCIT:C32281 xref: SCTID:272023004 xref: TAO:0005168 xref: Wikipedia:Central_veins_of_liver xref: ZFA:0005168 is_a: UBERON:0013126 ! vein of abdomen is_a: UBERON:0015796 ! liver blood vessel relationship: BFO:0000050 UBERON:0004647 ! part of liver lobule property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0006843 name: root of cranial nerve def: "The initial segment of a cranial nerve, leaving the central nervous system." [http://orcid.org/0000-0002-6601-2165] subset: vertebrate_core synonym: "cranial nerve root" EXACT [FMA:52609] synonym: "cranial neural root" EXACT [FMA:52609] xref: FMA:52609 xref: HBA:9299 xref: SCTID:280161004 xref: TAO:0002190 xref: ZFA:0001663 is_a: UBERON:0002211 ! nerve root is_a: UBERON:0011215 ! central nervous system cell part cluster intersection_of: UBERON:0002211 ! nerve root intersection_of: BFO:0000050 UBERON:0001017 ! part of central nervous system intersection_of: extends_fibers_into UBERON:0001785 ! cranial nerve relationship: extends_fibers_into UBERON:0001785 ! cranial nerve property_value: IAO:0000116 "recommend asserting under this class rather than relying on inference, as relations may change" xsd:string property_value: skos:prefLabel "root of cranial nerve" xsd:string [Term] id: UBERON:0006846 name: surface groove def: "A furrow or an incomplete tube." [AEO:0000161, AEO:JB, https://github.com/obophenotype/human-developmental-anatomy-ontology/issues/4] comment: Surface groove is modelled as immaterial - see https://github.com/obophenotype/uberon/issues/2667 for discussion subset: grouping_class synonym: "groove" RELATED [AEO:0000161] xref: AEO:0000161 xref: EHDAA2_RETIRED:0003161 is_a: UBERON:0000466 ! immaterial anatomical entity relationship: RO:0000086 PATO:0002255 ! has quality grooved property_value: seeAlso "https://github.com/obophenotype/uberon/issues/2667" xsd:string property_value: skos:prefLabel "surface groove" xsd:string [Term] id: UBERON:0006847 name: cerebellar commissure def: "A nervous system commissure that connects a left hemisphere of cerebellum and connects a right hemisphere of cerebellum." [OBOL:automatic] subset: vertebrate_core synonym: "commissura cerebelli" EXACT [ZFA:0000490] synonym: "commissure of cerebellum" EXACT [] xref: BAMS:cbc xref: DMBA:17754 xref: FMA:77522 xref: MBA:744 xref: neuronames:1752 xref: TAO:0000490 xref: ZFA:0000490 is_a: UBERON:0001020 ! nervous system commissure intersection_of: UBERON:0001020 ! nervous system commissure intersection_of: RO:0002176 UBERON:0014889 ! connects left hemisphere of cerebellum intersection_of: RO:0002176 UBERON:0014890 ! connects right hemisphere of cerebellum relationship: BFO:0000050 UBERON:0002317 ! part of white matter of cerebellum relationship: RO:0002176 UBERON:0014889 ! connects left hemisphere of cerebellum relationship: RO:0002176 UBERON:0014890 ! connects right hemisphere of cerebellum property_value: skos:prefLabel "cerebellar commissure" xsd:string [Term] id: UBERON:0006849 name: scapula def: "Endochondral bone that is dorsoventrally compressed and provides attachment site for muscles of the pectoral appendage." [https://github.com/obophenotype/uberon/issues/204, https://github.com/obophenotype/uberon/issues/339, VSAO:0000157] subset: efo_slim subset: human_reference_atlas subset: pheno_slim subset: uberon_slim synonym: "scapula bone" RELATED [BTO:0001218] synonym: "scapulae" EXACT OMO:0003004 [ZFA:0000583] synonym: "scapulas" RELATED OMO:0003004 [TAO:0000583] synonym: "shoulder blade" NARROW [] xref: AAO:0000751 xref: BTO:0001218 xref: CALOHA:TS-0897 xref: EFO:0001400 xref: EMAPA:18722 xref: FMA:13394 xref: GAID:186 xref: galen:Scapula xref: MA:0001330 xref: MESH:D012540 xref: NCIT:C12783 xref: SCTID:302517007 xref: TAO:0000583 xref: UMLS:C0036277 {source="ncithesaurus:Scapula"} xref: VHOG:0001398 xref: VSAO:0000157 xref: Wikipedia:Scapula xref: ZFA:0000583 is_a: UBERON:0002513 ! endochondral bone is_a: UBERON:0007829 ! pectoral girdle bone is_a: UBERON:0015057 ! scapula endochondral element intersection_of: UBERON:0015057 ! scapula endochondral element intersection_of: RO:0002473 UBERON:0002481 ! composed primarily of bone tissue relationship: distally_connected_to UBERON:0007272 ! pectoral appendage skeleton relationship: RO:0002202 UBERON:0004753 {source="ZFA"} ! develops from scapulocoracoid relationship: RO:0002202 UBERON:0006290 {evidence="definitional"} ! develops from scapula cartilage element property_value: foaf:depiction "https://upload.wikimedia.org/wikipedia/commons/5/59/Pectoral_girdles-en.svg" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0006851 name: renal cortex peritubular capillary def: "A peritubular capillary that is part of a cortex of kidney." [OBOL:automatic] synonym: "kidney cortex peritubular capillary" EXACT [MA:0002590] xref: EMAPA:37488 {source="MA:th"} xref: MA:0002590 is_a: UBERON:0005272 ! peritubular capillary intersection_of: UBERON:0005272 ! peritubular capillary intersection_of: BFO:0000050 UBERON:0001225 ! part of cortex of kidney relationship: BFO:0000050 UBERON:0001225 ! part of cortex of kidney [Term] id: UBERON:0006853 name: renal cortex tubule def: "A region of nephron tubule that is part of a cortex of kidney." [OBOL:automatic] synonym: "cortical tubule" RELATED [MA:0002609] synonym: "kidney cortex tubule" EXACT [MA:0002609] xref: EMAPA:18976 xref: MA:0002609 is_a: UBERON:0007685 ! region of nephron tubule intersection_of: UBERON:0007685 ! region of nephron tubule intersection_of: BFO:0000050 UBERON:0001225 ! part of cortex of kidney relationship: BFO:0000050 UBERON:0001225 {source="MA"} ! part of cortex of kidney [Term] id: UBERON:0006854 name: distal straight tubule postmacula segment synonym: "cortical thick ascending limb of Henle's loop" EXACT [MA:th] synonym: "kidney cortex loop of Henle ascending limb thick segment" EXACT [MA:th] synonym: "renal cortex loop of Henle ascending limb thick segment" EXACT [MA:th] synonym: "renal cortex thick ascending limb" EXACT [MA:th] xref: EMAPA:28402 xref: MA:0002615 is_a: UBERON:0006853 ! renal cortex tubule relationship: BFO:0000050 UBERON:0001291 {source="MA"} ! part of thick ascending limb of loop of Henle relationship: BFO:0000050 UBERON:0006853 {source="MA"} ! part of renal cortex tubule property_value: IAO:0000233 "https://sourceforge.net/tracker/?func=detail&aid=3123598&group_id=76834&atid=1205376" xsd:anyURI [Term] id: UBERON:0006855 name: muscular coat of ureter def: "A muscular coat that is part of a ureter." [OBOL:automatic] synonym: "muscular coat of ureter" EXACT [FMA:15893] synonym: "muscular layer of ureter" EXACT [FMA:15893] synonym: "muscularis of ureter" EXACT [FMA:15893] synonym: "tunica muscularis (ureter)" EXACT OMO:0003011 [FMA:TA] synonym: "tunica muscularis ureteris" EXACT OMO:0003011 [FMA:TA] synonym: "ureteral smooth muscle layer" RELATED [EMAPA:28567] xref: FMA:15893 xref: MA:0002654 xref: SCTID:3563003 is_a: UBERON:0006660 ! muscular coat intersection_of: UBERON:0006660 ! muscular coat intersection_of: BFO:0000050 UBERON:0000056 ! part of ureter relationship: BFO:0000050 UBERON:0009916 {source="FMA"} ! part of wall of ureter [Term] id: UBERON:0006858 name: adrenal/interrenal gland def: "This gland can either be a discrete structure located bilaterally above each kidney, or a cluster of cells in the head kidney that perform the functions of the adrenal gland. In either case, this organ consists of two cells types, aminergic chromaffin cells and steroidogenic cortical cells[GO]." [GO:0030325] subset: homology_grouping subset: organ_slim synonym: "adrenal - interrenal gland" RELATED [VHOG:0001141] synonym: "adrenal gland - interrenal gland" EXACT [VHOG:0001141] synonym: "adrenal gland/interrenal tissue" EXACT [] synonym: "suprarenal gland - interrenal gland" RELATED [VHOG:0001141] is_a: UBERON:0002368 ! endocrine gland is_a: UBERON:0004120 ! mesoderm-derived structure relationship: BFO:0000050 UBERON:0010074 ! part of chromaffin system relationship: BFO:0000051 CL:0000166 ! has part chromaffin cell relationship: BFO:0000051 CL:0000457 ! has part biogenic amine secreting cell relationship: RO:0002202 UBERON:0003064 ! develops from intermediate mesoderm property_value: IAO:0000116 "keep this grouping class so long as it is required for GO" xsd:string [Term] id: UBERON:0006861 name: diaphysis proper def: "Subdivision of long bone which forms the part of the bone between two metaphyses. Note that the diaphysis includes the metaphyses, but the diaphysis proper excludes these." [https://orcid.org/0000-0002-6601-2165] subset: pheno_slim synonym: "body proper of long bone" EXACT [FMA:32688] synonym: "long bone diaphysis" RELATED INCONSISTENT [MA:0002803] synonym: "shaft proper of long bone" EXACT [FMA:32688] xref: FMA:32688 xref: MA:0002803 is_a: UBERON:0005055 ! zone of long bone relationship: BFO:0000050 UBERON:0004769 ! part of diaphysis relationship: RO:0002433 UBERON:0002495 ! contributes to morphology of long bone [Term] id: UBERON:0006862 name: diaphysis of femur def: "A diaphysis that is part of a femur[Automatically generated definition]." [OBOL:automatic, Wikipedia:Body_of_femur] subset: pheno_slim synonym: "body of femur" EXACT [FMA:32847] synonym: "corpus femoris" EXACT OMO:0003011 [FMA:32847, FMA:TA] synonym: "femoral diaphysis" EXACT [FMA:32847] synonym: "femoral shaft" EXACT [] synonym: "shaft of femur" EXACT [FMA:32847] xref: EMAPA:37538 {source="MA:th"} xref: FMA:32847 xref: MA:0003055 xref: NCIT:C96209 xref: SCTID:182048009 xref: Wikipedia:Body_of_femur is_a: UBERON:0004769 ! diaphysis intersection_of: UBERON:0004769 ! diaphysis intersection_of: BFO:0000050 UBERON:0000981 ! part of femur relationship: BFO:0000050 UBERON:0000981 ! part of femur property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/2/2b/Gray244.png" xsd:anyURI [Term] id: UBERON:0006863 name: proximal metaphysis of femur def: "A proximal metaphysis that is part of a femur." [OBOL:automatic] subset: pheno_slim xref: FMA:32878 is_a: UBERON:0004378 ! proximal metaphysis is_a: UBERON:0006865 ! metaphysis of femur intersection_of: UBERON:0004378 ! proximal metaphysis intersection_of: BFO:0000050 UBERON:0000981 ! part of femur [Term] id: UBERON:0006865 name: metaphysis of femur def: "A metaphysis that is part of a femur." [OBOL:automatic] subset: pheno_slim synonym: "femoral metaphysis" EXACT [FMA:32875] xref: EMAPA:37540 {source="MA:th"} xref: FMA:32875 xref: MA:0003052 is_a: UBERON:0001438 ! metaphysis intersection_of: UBERON:0001438 ! metaphysis intersection_of: BFO:0000050 UBERON:0000981 ! part of femur relationship: BFO:0000050 UBERON:0006862 {is_inferred="true", source="https://github.com/obophenotype/uberon/wiki/Inferring-part-of-relationships"} ! part of diaphysis of femur [Term] id: UBERON:0006866 name: terminal part of digestive tract def: "The distalmost portion of the digestive tract, derived from the hindgut, and terminating with the anus." [http://orcid.org/0000-0002-6601-2165] synonym: "rectal part of digestive tract" RELATED [] synonym: "rectum" NARROW [FBbt:00005756] synonym: "terminal section of digestive tract" RELATED [] xref: FBbt:00005756 {sssom:mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"} xref: WBbt:0005773 is_a: BFO:0000002 is_a: UBERON:0004921 ! subdivision of digestive tract relationship: RO:0002150 UBERON:0001245 ! continuous with anus relationship: RO:0002202 UBERON:0001046 ! develops from hindgut property_value: skos:prefLabel "terminal part of digestive tract" xsd:string [Term] id: UBERON:0006868 name: seminal fluid secreting gland def: "A gland that secretes a seminal fluid." [OBOL:automatic] subset: grouping_class subset: organ_slim xref: FBbt:00004958 {sssom:mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"} xref: WBbt:0006870 is_a: UBERON:0005399 ! male reproductive gland intersection_of: UBERON:0002530 ! gland intersection_of: RO:0003000 UBERON:0006530 ! produces seminal fluid relationship: BFO:0000050 UBERON:0006947 ! part of male genital duct relationship: RO:0003000 UBERON:0006530 ! produces seminal fluid [Term] id: UBERON:0006871 name: embryonic footplate def: "The distal elements of the developing limb of vertebrates that will give rise to the pes (foot)." [https://github.com/obophenotype/mammalian-phenotype-ontology/issues/2218, MGI:csmith, MP:0004576, UBERON:cjm] subset: pheno_slim synonym: "distal part of hindlimb bud" RELATED [EMAPA:17249] synonym: "foot disk" RELATED [] synonym: "foot plate" BROAD [] synonym: "footplate" BROAD [] xref: EHDAA:5143 xref: EHDAA:6096 xref: EMAPA:17249 xref: FMA:296800 xref: NCIT:C34177 xref: UMLS:C1517291 {source="ncithesaurus:Foot_Plate"} is_a: UBERON:0010130 ! embryonic autopod plate intersection_of: UBERON:0010130 ! embryonic autopod plate intersection_of: RO:0002387 UBERON:0002387 ! has potential to develop into pes relationship: RO:0002202 UBERON:0005418 ! develops from hindlimb bud relationship: RO:0002387 UBERON:0002387 ! has potential to develop into pes [Term] id: UBERON:0006872 name: handplate apical ectodermal ridge def: "An apical ectodermal ridge that is part of a handplate." [OBOL:automatic] xref: EHDAA2:0000729 xref: EMAPA:17247 is_a: UBERON:0004356 ! apical ectodermal ridge intersection_of: UBERON:0004356 ! apical ectodermal ridge intersection_of: BFO:0000050 UBERON:0006875 ! part of embryonic handplate relationship: BFO:0000050 UBERON:0006875 ! part of embryonic handplate [Term] id: UBERON:0006875 name: embryonic handplate def: "The distal elements of the developing limb of vertebrates that will give rise to the manus (hand)." [MGI:csmith, MP:0004576, UBERON:cjm] synonym: "distal part of forelimb bud" RELATED [EMAPA:17245] synonym: "hand plate" EXACT [] synonym: "handplate" EXACT [] xref: EHDAA:4194 xref: EHDAA:6242 xref: EMAPA:17245 xref: FMA:296794 xref: NCIT:C34185 xref: UMLS:C1512334 {source="ncithesaurus:Hand_Plate"} is_a: UBERON:0010130 ! embryonic autopod plate intersection_of: UBERON:0010130 ! embryonic autopod plate intersection_of: RO:0002387 UBERON:0002398 ! has potential to develop into manus relationship: RO:0002202 UBERON:0005417 ! develops from forelimb bud relationship: RO:0002387 UBERON:0002398 ! has potential to develop into manus [Term] id: UBERON:0006876 name: vasculature of organ def: "A vasculature that is part of a organ." [OBOL:automatic] subset: non_informative synonym: "organ vasculature" EXACT [FMA:74612] synonym: "set of blood vessels of organ" EXACT [FMA:74612] xref: FMA:74612 is_a: UBERON:0002049 ! vasculature intersection_of: UBERON:0002049 ! vasculature intersection_of: BFO:0000050 UBERON:0000062 ! part of organ relationship: BFO:0000050 UBERON:0000062 ! part of organ property_value: skos:prefLabel "vasculature of organ" xsd:string [Term] id: UBERON:0006877 name: vasculature of liver def: "A vasculature that is part of a liver." [OBOL:automatic] subset: pheno_slim synonym: "hepatic vascular element" RELATED [EMAPA:35501] synonym: "hepatic vasculature" EXACT [FMA:73748] synonym: "liver vascular element" RELATED [EMAPA:35501] synonym: "liver vascular system" RELATED [EHDAA2:0003454] xref: EHDAA2:0003454 xref: EMAPA:35501 xref: FMA:73748 is_a: UBERON:0002201 ! vasculature of trunk is_a: UBERON:0006876 ! vasculature of organ intersection_of: UBERON:0002049 ! vasculature intersection_of: BFO:0000050 UBERON:0002107 ! part of liver relationship: BFO:0000050 UBERON:0002107 ! part of liver property_value: skos:prefLabel "vasculature of liver" xsd:string [Term] id: UBERON:0006904 name: head mesenchyme from mesoderm def: "A head mesenchyme that develops_from a mesoderm." [OBOL:automatic] subset: efo_slim subset: vertebrate_core synonym: "cranial mesoderm" RELATED [UBERON:0005280] synonym: "head mesenchyme derived from mesoderm" EXACT [] synonym: "head mesenchyme from head mesoderm" EXACT [EHDAA2:0001118] synonym: "head mesenchyme from mesoderm" EXACT [] synonym: "head mesoderm" RELATED [AAO:0011051, UBERON:0005280] synonym: "mesenchyme derived from head mesoderm" EXACT [EHDAA:1057] synonym: "mesenchyme from head mesoderm" EXACT [] xref: AAO:0011051 xref: EFO:0003337 xref: EFO:0003603 xref: EHDAA2:0001118 xref: EHDAA:655 xref: EMAPA:16099 xref: EMAPA_RETIRED:16270 xref: FMA:293859 xref: TAO:0000998 xref: VHOG:0000185 xref: XAO:0000053 xref: ZFA:0000998 is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0005253 {source="ZFA"} ! head mesenchyme intersection_of: UBERON:0005253 ! head mesenchyme intersection_of: RO:0002202 UBERON:0000926 ! develops from mesoderm relationship: RO:0002202 UBERON:0003063 {source="EHDAA2", source="XAO"} ! develops from prechordal plate property_value: IAO:0000116 "merged in 'head mesoderm' from XAO/AAO and EFO here. Partially implements https://github.com/obophenotype/uberon/wiki/The-neural-crest NC meeting scheme" xsd:string property_value: skos:prefLabel "head mesenchyme from mesoderm" xsd:string [Term] id: UBERON:0006905 name: mandibular process mesenchyme def: "Mesenchyme that is part of a mandibular prominence." [OBOL:automatic] synonym: "mesenchyme of mandibular process" EXACT [EMAPA:17357] synonym: "mesenchyme of mandibular prominence" EXACT [https://orcid.org/0000-0002-6601-2165] xref: EHDAA2:0001062 xref: EHDAA:5861 xref: EHDAA:5873 xref: EMAPA:17357 is_a: UBERON:0005253 ! head mesenchyme intersection_of: UBERON:0003104 ! mesenchyme intersection_of: BFO:0000050 UBERON:0005867 ! part of mandibular prominence relationship: BFO:0000050 UBERON:0005867 ! part of mandibular prominence property_value: skos:prefLabel "mandibular process mesenchyme" xsd:string [Term] id: UBERON:0006907 name: slow muscle tissue def: "The darker-colored muscle tissue of some mammals, composed of slow twitch muscle fibers." [BTO:0002317] synonym: "red muscle" RELATED [BTO:0002317] synonym: "slow muscle" EXACT [BTO:0002317] synonym: "slow skeletal muscle tissue" EXACT [] synonym: "slow-twitch skeletal muscle" EXACT [CALOHA:TS-0940] xref: BTO:0002317 xref: CALOHA:TS-0940 xref: NCIT:C12614 xref: UMLS:C0242874 {source="ncithesaurus:Muscle_Fibers_Slow-Twitch"} is_a: UBERON:0001134 ! skeletal muscle tissue intersection_of: UBERON:0001134 ! skeletal muscle tissue intersection_of: BFO:0000051 CL:0000189 ! has part slow muscle cell relationship: RO:0002473 CL:0000189 ! composed primarily of slow muscle cell property_value: IAO:0000116 "check if relationship to cell types should be more specific type I cells" xsd:string [Term] id: UBERON:0006908 name: fast muscle tissue def: "The paler-colored muscle tissue of some mammals, composed of fast twitch muscle fibers." [BTO:0002318] comment: The fast and slow skeletal muscles are different in terms of twitching speed (Fitts 1994), and they are believed to be derived from distinct myogenic precursors (Stockdale 1992) synonym: "fast muscle" EXACT [BTO:0002318] synonym: "fast skeletal muscle tissue" EXACT [] synonym: "white muscle" RELATED [BTO:0002318] xref: BTO:0002318 xref: NCIT:C12613 xref: UMLS:C0242873 {source="ncithesaurus:Muscle_Fibers_Fast-Twitch"} is_a: UBERON:0001134 ! skeletal muscle tissue intersection_of: UBERON:0001134 ! skeletal muscle tissue intersection_of: BFO:0000051 CL:0000190 ! has part fast muscle cell relationship: RO:0002473 CL:0000190 ! composed primarily of fast muscle cell [Term] id: UBERON:0006909 name: lumen of digestive tract def: "An anatomical space that surrounded_by a digestive tract." [OBOL:automatic] synonym: "digestive tract lumen" EXACT [https://orcid.org/0000-0002-6601-2165] synonym: "gut cavity" EXACT [BTO:0000349] synonym: "gut lumen" EXACT [FMA:45677] synonym: "lumen of alimentary tract" EXACT [https://orcid.org/0000-0002-6601-2165] synonym: "lumen of digestive tract" EXACT [https://orcid.org/0000-0002-6601-2165] synonym: "lumen of gut" EXACT [FMA:45677] xref: BTO:0000349 xref: EMAPA:32908 xref: FMA:45677 is_a: UBERON:0000464 ! anatomical space intersection_of: UBERON:0000464 ! anatomical space intersection_of: RO:0002572 UBERON:0001555 ! luminal space of digestive tract relationship: RO:0002572 UBERON:0001555 ! luminal space of digestive tract property_value: skos:prefLabel "lumen of digestive tract" xsd:string [Term] id: UBERON:0006912 name: urinary bladder muscularis mucosa def: "A thin layer of smooth muscle within the bladder lamina propria." [http://www.pathologyoutlines.com/topic/bladderhistology.html, NCIT:C32207] synonym: "muscularis mucosa of bladder" BROAD [EMAPA:28619] synonym: "muscularis mucosa of urinary bladder" EXACT [OBOL:automatic] xref: EMAPA:28619 xref: MA:0002490 xref: NCIT:C32207 xref: UMLS:C1511195 {source="ncithesaurus:Bladder_Muscularis_Mucosa"} is_a: UBERON:0004228 ! urinary bladder smooth muscle is_a: UBERON:0006676 ! muscularis mucosa intersection_of: UBERON:0006676 ! muscularis mucosa intersection_of: BFO:0000050 UBERON:0001255 ! part of urinary bladder relationship: BFO:0000050 UBERON:0001261 ! part of lamina propria of urinary bladder [Term] id: UBERON:0006913 name: lip epithelium def: "An epithelium that is part of a lip." [OBOL:automatic] xref: BTO:0004468 xref: TAO:0005334 xref: ZFA:0005334 is_a: UBERON:0003929 ! digestive tract epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: BFO:0000050 UBERON:0001833 ! part of lip relationship: BFO:0000050 UBERON:0001833 ! part of lip property_value: skos:prefLabel "lip epithelium" xsd:string [Term] id: UBERON:0006914 name: squamous epithelium def: "An epithelium characterised by its most superficial layer consisting of squamous epithelial cells." [Wikipedia:Squamous_epithelium] xref: BTO:0002072 xref: NCIT:C12848 xref: SCTID:40118003 xref: UMLS:C0221909 {source="ncithesaurus:Squamous_Epithelium"} xref: Wikipedia:Squamous_epithelium is_a: UBERON:0000483 ! epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: RO:0002473 CL:0000076 ! composed primarily of squamous epithelial cell relationship: RO:0002473 CL:0000076 ! composed primarily of squamous epithelial cell property_value: skos:prefLabel "squamous epithelium" xsd:string [Term] id: UBERON:0006915 name: stratified squamous epithelium def: "Multilaminar epithelium which consists of more than one layer of squamous cells only one layer of which is in contact with a basement membrane. Examples: keratinized stratified squamous epithelium, epithelium of wall of esophagus.[FMA]." [FMA:45563, Wikipedia:Stratified_squamous_epithelium] subset: pheno_slim synonym: "epithelium stratificatum squamosum" EXACT [FMA:45563] xref: FMA:45563 xref: NCIT:C13180 xref: UMLS:C0836131 {source="ncithesaurus:Stratified_Squamous_Epithelium"} xref: Wikipedia:Stratified_squamous_epithelium is_a: UBERON:0000486 ! multilaminar epithelium is_a: UBERON:0006914 ! squamous epithelium intersection_of: UBERON:0000486 ! multilaminar epithelium intersection_of: RO:0002473 CL:0000076 ! composed primarily of squamous epithelial cell property_value: skos:prefLabel "stratified squamous epithelium" xsd:string [Term] id: UBERON:0006916 name: non-keratinized epithelium of tongue def: "A non-keratinized stratified squamous epithelium that is part of a tongue." [OBOL:automatic] subset: human_reference_atlas xref: FMA:62130 is_a: UBERON:0006919 ! tongue squamous epithelium is_a: UBERON:0010304 ! non-keratinized stratified squamous epithelium intersection_of: UBERON:0010304 ! non-keratinized stratified squamous epithelium intersection_of: BFO:0000050 UBERON:0001723 ! part of tongue property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0006919 name: tongue squamous epithelium def: "A squamous epithelium that is part of a tongue." [OBOL:automatic] subset: human_reference_atlas subset: pheno_slim synonym: "squamous epithelium of tongue" EXACT [OBOL:automatic] xref: MA:0002786 is_a: UBERON:0002424 ! oral epithelium is_a: UBERON:0003357 ! epithelium of tongue is_a: UBERON:0006914 ! squamous epithelium intersection_of: UBERON:0006914 ! squamous epithelium intersection_of: BFO:0000050 UBERON:0001723 ! part of tongue relationship: BFO:0000050 UBERON:0005020 ! part of mucosa of tongue property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "tongue squamous epithelium" xsd:string [Term] id: UBERON:0006920 name: esophagus squamous epithelium def: "A squamous epithelium that is part of a esophagus." [OBOL:automatic] subset: pheno_slim synonym: "esophageal squamous epithelium" RELATED [OBOL:automatic] synonym: "squamous epithelium of esophagus" RELATED [OBOL:automatic] synonym: "squamous oesophageal epithelium" RELATED [MA:0001567] xref: BTO:0003635 xref: CALOHA:TS-1250 xref: EMAPA:35324 xref: MA:0001567 xref: NCIT:C49222 xref: UMLS:C1707950 {source="ncithesaurus:Esophageal_Squamous_Epithelium"} is_a: UBERON:0001976 ! epithelium of esophagus is_a: UBERON:0006914 ! squamous epithelium intersection_of: UBERON:0006914 ! squamous epithelium intersection_of: BFO:0000050 UBERON:0001043 ! part of esophagus property_value: skos:prefLabel "esophagus squamous epithelium" xsd:string [Term] id: UBERON:0006921 name: stomach squamous epithelium def: "A squamous epithelium that is part of a stomach." [OBOL:automatic] subset: pheno_slim xref: EMAPA:35824 xref: MA:0001611 is_a: UBERON:0000487 ! simple squamous epithelium is_a: UBERON:0001276 ! epithelium of stomach intersection_of: UBERON:0006914 ! squamous epithelium intersection_of: BFO:0000050 UBERON:0000945 ! part of stomach property_value: skos:prefLabel "stomach squamous epithelium" xsd:string [Term] id: UBERON:0006922 name: cervix squamous epithelium def: "The squamous epithelium of the cervical portio is similar to that of the vagina, except that it is generally smooth and lacks rete pegs. Colposcopically, it appears featureless except for a fine network of vessels which is sometimes visible. The relative opacity and pale pink coloration of the squamous epithelium derives from its multi-layered histology and the location of its supporting vessels below the basement membrane." [http://www.asccp.org/practicemanagement/cervix/histologyofthenormalcervix/tabid/5842/default.aspx] subset: human_reference_atlas subset: pheno_slim synonym: "cervical squamous epithelium" EXACT [] xref: MA:0001725 xref: NCIT:C49219 xref: UMLS:C1707351 {source="ncithesaurus:Cervix_Squamous_Epithelium"} is_a: UBERON:0004801 ! cervix epithelium is_a: UBERON:0010304 ! non-keratinized stratified squamous epithelium intersection_of: UBERON:0006914 ! squamous epithelium intersection_of: BFO:0000050 UBERON:0000002 ! part of uterine cervix property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0006923 name: vagina squamous epithelium def: "A squamous epithelium that is part of a vagina." [OBOL:automatic] synonym: "vaginal squamous epithelium" EXACT [] xref: EMAPA:37794 {source="MA:th"} xref: MA:0001731 xref: NCIT:C49314 xref: UMLS:C1711259 {source="ncithesaurus:Vaginal_Squamous_Epithelium"} is_a: UBERON:0001344 ! epithelium of vagina is_a: UBERON:0006915 ! stratified squamous epithelium intersection_of: UBERON:0006914 ! squamous epithelium intersection_of: BFO:0000050 UBERON:0000996 ! part of vagina [Term] id: UBERON:0006924 name: stomach glandular epithelium def: "A glandular epithelium that lines the stomach. The stomach's glandular epithelium is characterized by the presence of gastric glands." [ISBN:0073040584] subset: pheno_slim synonym: "epithelium of gastric gland" NARROW [FMA:63458] synonym: "gastric gland epithelium" RELATED [FMA:63458] xref: EMAPA:35814 xref: FMA:63458 xref: MA:0002784 is_a: UBERON:0001276 ! epithelium of stomach is_a: UBERON:0006929 {source="FMA"} ! glandular columnar epithelium intersection_of: UBERON:0006799 ! glandular epithelium intersection_of: BFO:0000050 UBERON:0000945 ! part of stomach relationship: BFO:0000050 UBERON:0006931 ! part of stomach glandular region mucosa relationship: BFO:0000051 UBERON:0000325 ! has part gastric gland property_value: IAO:0000116 "we follow Kardong in treating the glandular epithelium as a distinct entity, and thus as an epithelium which has glands; FMA has 'epithelium of gastric gland', which is part of the gastric gland." xsd:string property_value: skos:prefLabel "stomach glandular epithelium" xsd:string [Term] id: UBERON:0006925 name: digestive system gland def: "Any gland that is part of the digestive system." [UBERON:cjm] subset: organ_slim synonym: "digestive gland" RELATED [BTO:0000345] xref: AAO:0000130 xref: BTO:0000345 is_a: UBERON:0002368 ! endocrine gland is_a: UBERON:0013765 ! digestive system element intersection_of: UBERON:0002368 ! endocrine gland intersection_of: BFO:0000050 UBERON:0001007 ! part of digestive system property_value: skos:prefLabel "digestive system gland" xsd:string [Term] id: UBERON:0006929 name: glandular columnar epithelium def: "Simple columnar epithelium that constitutes the secretory part of a gland. Examples: epithelium of stomach, luminal epithelium of lactiferous duct.[FMA]." [FMA:64800] xref: FMA:64800 xref: NCIT:C13182 xref: UMLS:C0225337 {source="ncithesaurus:Columnar_Epithelium"} is_a: UBERON:0000485 ! simple columnar epithelium is_a: UBERON:0006799 ! glandular epithelium intersection_of: UBERON:0000485 ! simple columnar epithelium intersection_of: RO:0002473 CL:0000150 ! composed primarily of glandular secretory epithelial cell property_value: skos:prefLabel "glandular columnar epithelium" xsd:string [Term] id: UBERON:0006930 name: glandular cuboidal epithelium xref: FMA:66809 is_a: UBERON:0000484 ! simple cuboidal epithelium is_a: UBERON:0006799 ! glandular epithelium intersection_of: UBERON:0000484 ! simple cuboidal epithelium intersection_of: RO:0002473 CL:0000150 ! composed primarily of glandular secretory epithelial cell property_value: skos:prefLabel "glandular cuboidal epithelium" xsd:string [Term] id: UBERON:0006931 name: stomach glandular region mucosa def: "Stomach mucosa that is lined with glandular epithelium and part of a stomach glandular region." [http://orcid.org/0000-0002-6601-2165] synonym: "stomach glandular region glandular mucous membrane" EXACT [EMAPA:27167] xref: EMAPA:27167 xref: MA:0001614 is_a: UBERON:0001199 ! mucosa of stomach intersection_of: UBERON:0001199 ! mucosa of stomach intersection_of: BFO:0000050 UBERON:0011953 ! part of stomach glandular region relationship: BFO:0000050 UBERON:0011953 ! part of stomach glandular region property_value: skos:prefLabel "stomach glandular region mucosa" xsd:string [Term] id: UBERON:0006932 name: vestibular epithelium def: "An epithelium that is part of a vestibular labyrinth." [OBOL:automatic] synonym: "epithelium of vestibular labyrinth" EXACT [OBOL:automatic] synonym: "inner ear vestibular component epithelium" EXACT [RETIRED_EHDAA2:0000834] synonym: "vestibular sensory epithelium" EXACT [FMA:75606] xref: BTO:0005581 xref: EMAPA:32884 xref: EMAPA:35921 xref: FMA:75606 xref: MA:0002892 xref: RETIRED_EHDAA2:0000834 is_a: UBERON:0006934 ! sensory epithelium is_a: UBERON:0006937 ! inner ear epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: BFO:0000050 UBERON:0001862 ! part of vestibular labyrinth relationship: BFO:0000050 UBERON:0001862 ! part of vestibular labyrinth property_value: skos:prefLabel "vestibular epithelium" xsd:string [Term] id: UBERON:0006934 name: sensory epithelium def: "Simple columnar epithelium made up of cells specialized to serve as sensory cells for the reception of external stimuli, as the sensory cells of the cochlea, vestibule, nasal mucosa, and tongue." [BTO:0000314] synonym: "neuroepithelium" RELATED INCONSISTENT [BTO:0000314] xref: CALOHA:TS-0682 xref: FMA:62410 xref: SCTID:309045006 is_a: UBERON:0000488 ! atypical epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: BFO:0000051 CL:0000098 ! has part sensory epithelial cell relationship: BFO:0000050 UBERON:0000010 ! part of peripheral nervous system relationship: BFO:0000051 CL:0000098 ! has part sensory epithelial cell property_value: skos:prefLabel "sensory epithelium" xsd:string [Term] id: UBERON:0006935 name: crista ampullaris neuroepithelium def: "An epithelium that is part of a crista ampullaris." [OBOL:automatic] subset: pheno_slim synonym: "ampullary crest neuroepithelium" RELATED [MA:0002870] synonym: "epithelium of crista of ampulla of semicircular duct of membranous labyrinth" EXACT [FMA:75636] xref: FMA:75636 xref: MA:0002870 is_a: BFO:0000002 is_a: UBERON:0006932 {source="FMA"} ! vestibular epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: BFO:0000050 UBERON:0004721 ! part of crista ampullaris relationship: BFO:0000050 UBERON:0004721 {source="MA"} ! part of crista ampullaris relationship: BFO:0000051 CL:0002316 {source="FMA"} ! has part supporting cell of vestibular epithelium relationship: RO:0002433 UBERON:0004721 ! contributes to morphology of crista ampullaris [Term] id: UBERON:0006936 name: thymus subcapsular epithelium def: "The epithelial cells lining the capsule and trabeculae of the thymus." [ISBN:0-8153-1691-7, MGI:cwg, MP:0002369] subset: human_reference_atlas subset: pheno_slim xref: MA:0000769 is_a: UBERON:0003846 ! thymus epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: BFO:0000050 UBERON:0002122 ! part of capsule of thymus relationship: BFO:0000050 UBERON:0002122 ! part of capsule of thymus relationship: BFO:0000051 CL:0002294 ! has part type-1 epithelial cell of thymus property_value: IAO:0000116 "TODO - check whether this is part of the thymus or borders it" xsd:string property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0006937 name: inner ear epithelium def: "The epithelial cell layer containing the sensory hair cells and their associated sensory nerve terminals." [MGI:csmith, MP:0003308] subset: pheno_slim xref: EMAPA:32883 xref: MA:0001189 is_a: UBERON:0015807 ! ear epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: BFO:0000050 UBERON:0001846 ! part of internal ear relationship: BFO:0000050 UBERON:0001846 ! part of internal ear property_value: skos:prefLabel "inner ear epithelium" xsd:string [Term] id: UBERON:0006938 name: pinna surface epithelium def: "An epithelium that is part of a pinna." [OBOL:automatic] xref: EHDAA2:0001470 xref: EHDAA:8983 xref: EMAPA:17592 xref: VHOG:0000632 is_a: UBERON:0015814 ! outer ear epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: BFO:0000050 UBERON:0001757 ! part of pinna relationship: BFO:0000050 UBERON:0001757 ! part of pinna [Term] id: UBERON:0006946 name: efferent duct def: "The efferent ducts (or efferent ductules or ductuli efferentes) connect the rete testis with the initial section of the epididymis. The ductuli are unilaminar and composed of columnar ciliated and non-ciliated (absorptive) cells. The ciliated cells serve to stir the luminal fluids, possibly to help ensure homogeneous absorption of water from the fluid produced by the testis, which results in an increase in the concentration of luminal sperm. The epithelium is surrounded by a band of smooth muscle that helps to propel the sperm toward the epididymis." [Wikipedia:Efferent_ducts] subset: pheno_slim synonym: "ductuli efferentes testis" RELATED OMO:0003011 [Wikipedia:Efferent_ducts] synonym: "efferent ductule" EXACT [FMA:19081, Wikipedia:Efferent_ducts] synonym: "seminal duct" EXACT [] synonym: "vasa efferentia" RELATED [AAO:0010532, Wikipedia:Efferent_ducts] xref: AAO:0010532 xref: EMAPA:18993 xref: FMA:19081 xref: MA:0000398 xref: NCIT:C32492 xref: UMLS:C0228013 {source="ncithesaurus:Efferent_Ductule"} xref: Wikipedia:Efferent_ducts is_a: UBERON:0000025 ! tube is_a: UBERON:0005904 ! duct of male reproductive system relationship: BFO:0000050 UBERON:0006947 {source="FMA"} ! part of male genital duct relationship: channel_for CL:0000019 ! sperm relationship: channels_from UBERON:0003959 ! rete testis relationship: channels_into UBERON:0001301 ! epididymis relationship: RO:0002162 NCBITaxon:7742 ! in taxon Vertebrata property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/b/b5/Hodenschema.svg" xsd:anyURI [Term] id: UBERON:0006947 name: male genital duct def: "A duct or series of ducts that transports sperm from the gonad. In mammals this is from the seminiferous tubules through rete testis, vas efferentia, epididymis, vas deferens, ejeculatory duct to the urethra." [https://orcid.org/0000-0002-6601-2165] subset: grouping_class synonym: "sperm duct" EXACT [ZFA:0001268] synonym: "sperm ducts" EXACT OMO:0003004 [TAO:0001268] xref: FMA:55678 xref: TAO:0001268 xref: ZFA:0001268 is_a: UBERON:0000025 ! tube is_a: UBERON:0005904 ! duct of male reproductive system is_a: UBERON:0015212 ! lateral structure relationship: BSPO:0000126 UBERON:0004054 {source="FMA-abduced-lr"} ! internal male genitalia relationship: channel_for UBERON:0001968 ! semen relationship: channels_from UBERON:0000473 ! testis [Term] id: UBERON:0006948 name: efferent duct epithelium def: "An epithelium that is part of a efferent duct." [OBOL:automatic] synonym: "epithelium of efferent ductule of testis" EXACT [FMA:19195] xref: EMAPA:29747 xref: FMA:19195 xref: MA:0001734 is_a: UBERON:0005156 ! reproductive structure is_a: UBERON:0034969 ! epithelial layer of duct intersection_of: UBERON:0000483 ! epithelium intersection_of: BFO:0000050 UBERON:0006946 ! part of efferent duct relationship: BFO:0000050 UBERON:0006946 ! part of efferent duct [Term] id: UBERON:0006953 name: ejaculatory duct epithelium def: "The ejaculatory duct epithelium is composed of cuboidal to columnar cells between or through which project the terminal parts of the ducts of the unicellular prostate glands." [PMID:1238970] xref: BTO:0002618 xref: EMAPA:29786 is_a: UBERON:0005156 ! reproductive structure is_a: UBERON:0034969 ! epithelial layer of duct intersection_of: UBERON:0000483 ! epithelium intersection_of: BFO:0000050 UBERON:0000999 ! part of ejaculatory duct relationship: BFO:0000050 UBERON:0000999 ! part of ejaculatory duct property_value: IAO:0000116 "TODO - split off insect classes" xsd:string [Term] id: UBERON:0006954 name: mammary gland myoepithelium def: "The outer cell layer of the mammary gland epithelium bilayer which is located basal to the luminal (secretory) cells and adjacent to the basement membrane." [MGI:anna] synonym: "lactiferous ductal myo-epithelium" EXACT [FMA:67798] synonym: "mammary myoepithelium" EXACT [BTO:0002310] synonym: "myo-epithelium of lactiferous duct" EXACT [FMA:67798] synonym: "myoepithelium of lactiferous duct" EXACT [FMA:67798] xref: BTO:0002310 xref: EMAPA:37903 {source="MA:th"} xref: FMA:67798 is_a: UBERON:0000420 ! myoepithelium is_a: UBERON:0003244 ! epithelium of mammary gland intersection_of: UBERON:0000420 ! myoepithelium intersection_of: BFO:0000050 UBERON:0001911 ! part of mammary gland relationship: BFO:0000051 CL:0002324 ! has part basal-myoepithelial cell of mammary gland [Term] id: UBERON:0006955 name: uterine epithelium def: "An epithelium that is part of a uterus." [OBOL:automatic] synonym: "uterus epithelium" RELATED [BTO:0003082] xref: BTO:0003082 is_a: UBERON:0004804 ! oviduct epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: BFO:0000050 UBERON:0000995 ! part of uterus relationship: BFO:0000050 UBERON:0000995 ! part of uterus [Term] id: UBERON:0006957 name: submandibular gland primordium epithelium def: "An epithelium that is part of a submandibular gland primordium." [OBOL:automatic] synonym: "submaxillary gland primordium epithelium" RELATED [EMAPA:17756] xref: EHDAA2:0001940 xref: EHDAA:9257 xref: EMAPA:17756 is_a: UBERON:0003236 ! epithelium of lower jaw is_a: UBERON:0005291 ! embryonic tissue intersection_of: UBERON:0000483 ! epithelium intersection_of: BFO:0000050 UBERON:0006298 ! part of submandibular gland primordium relationship: BFO:0000050 UBERON:0006298 ! part of submandibular gland primordium [Term] id: UBERON:0006960 name: ovary stroma def: "The stroma of the ovary is a peculiar soft tissue, abundantly supplied with blood vessels, consisting for the most part of spindle-shaped cells with a small amount of ordinary connective tissue. These cells have been regarded by some anatomists as unstriped muscle cells, which, indeed, they most resemble; by others as connective-tissue cells. On the surface of the organ this tissue is much condensed, and forms a layer composed of short connective-tissue fibers, with fusiform cells between them. The stroma of the ovary may contain interstitial cells resembling those of the testis." [Wikipedia:Stroma_of_ovary] subset: human_reference_atlas synonym: "interstitial tissue of ovary" EXACT [FMA:18626] synonym: "ovarian stroma" EXACT [FMA:18626] synonym: "ovary stroma" EXACT [MA:0002991] synonym: "stroma of the ovary" EXACT [Wikipedia:Stroma_of_ovary] synonym: "stroma ovarica" EXACT [FMA:18626] synonym: "stroma ovarii" RELATED OMO:0003011 [Wikipedia:Stroma_of_ovary] xref: CALOHA:TS-1246 xref: EMAPA:28880 xref: FMA:18626 xref: MA:0002991 xref: NCIT:C33638 xref: SCTID:259306002 xref: UMLS:C0737271 {source="ncithesaurus:Stroma_of_the_Ovarian_Cortex"} xref: Wikipedia:Stroma_of_ovary is_a: BFO:0000002 is_a: UBERON:0003891 ! stroma is_a: UBERON:0005156 ! reproductive structure intersection_of: UBERON:0003891 ! stroma intersection_of: BFO:0000050 UBERON:0000992 ! part of ovary relationship: BFO:0000050 UBERON:0000992 ! part of ovary relationship: BFO:0000051 CL:0002095 {source="FMA"} ! has part hilus cell of ovary property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0006964 name: pars distalis of adenohypophysis def: "The distal part of adenohypophysis: the part that makes up the main body of the gland." [Dorlands_Medical_Dictionary:MerckSource, Wikipedia:Pars_distalis] subset: vertebrate_core synonym: "anterior lobe" RELATED [MA:0000854] synonym: "DHP" BROAD OMO:0003000 [BIRNLEX:1022, NIFSTD:NeuroNames_abbrevSource] synonym: "distal part of hypophysis" EXACT [BIRNLEX:1022] synonym: "distal part of the hypophysis" RELATED [NeuroNames:410] synonym: "pars anterior" BROAD [EHDAA2:0001416, MA:0000854, ZFA:0001195] synonym: "pars anterior of adenohypophysis" EXACT [FMA:74630] synonym: "pars distalis" RELATED [MA:0000854] synonym: "pars distalis (glandula pituitaria)" EXACT OMO:0003011 [FMA:74630, FMA:TA] synonym: "pars distalis (hypophysis)" RELATED OMO:0003011 [NeuroNames:410] synonym: "pars distalis adenohypophyseos" RELATED [BTO:0001787] synonym: "pars distalis adenohypophysis" EXACT OMO:0003011 [FMA:74630, FMA:TA] synonym: "pars distalis lobi anterioris hypophyseos" RELATED [BTO:0001787] synonym: "pars distalis of anterior lobe of pituitary gland" EXACT [FMA:74630] synonym: "pars glandularis" RELATED [MA:0000854] synonym: "pars glandularis of adenohypophysis" EXACT [FMA:74630] xref: AAO:0010542 xref: BAMS:DHP xref: BIRNLEX:1022 xref: BTO:0001787 xref: EHDAA2:0001416 xref: EHDAA:7532 xref: EMAPA:17515 xref: FMA:74630 xref: MA:0000854 xref: neuronames:410 {source="BIRNLEX:1022"} xref: TAO:0001195 xref: UMLS:C0175322 {source="BIRNLEX:1022"} xref: VHOG:0000244 xref: Wikipedia:Pars_distalis xref: ZFA:0001195 is_a: UBERON:0000483 {source="EHDAA2"} ! epithelium is_a: UBERON:0005156 ! reproductive structure relationship: BFO:0000050 UBERON:0002196 {source="MA"} ! part of adenohypophysis property_value: skos:prefLabel "pars distalis of adenohypophysis" xsd:string [Term] id: UBERON:0006965 name: vascular cord def: "The vascular cord is the primordial vasculature that will develop into blood vessels by the process of tubulogenesis[GO]. The vascular cord is composed of angioblast or vascular endothelial cells in a solid linear mass called a cord. The cord then undergoes tubulogenesis to form the lumen of the vessels[ZFA]." [GO:0072360, ZFA:0005077] subset: efo_slim xref: EFO:0003709 xref: TAO:0005077 xref: ZFA:0005077 is_a: BFO:0000002 is_a: UBERON:0005423 ! developing anatomical structure relationship: BFO:0000050 UBERON:0014903 ! part of primordial vasculature relationship: BFO:0000051 CL:0000115 ! has part endothelial cell relationship: BFO:0000051 CL:0000566 ! has part angioblastic mesenchymal cell relationship: site_of GO:0048754 ! branching morphogenesis of an epithelial tube property_value: skos:prefLabel "vascular cord" xsd:string [Term] id: UBERON:0006966 name: coronary capillary def: "A capillary that is part of the coronary system." [http://orcid.org/0000-0002-6601-2165] synonym: "heart capillary" EXACT [GO:0003248] xref: ZFA:0005813 is_a: UBERON:0001982 ! capillary is_a: UBERON:0003498 ! heart blood vessel intersection_of: UBERON:0001982 ! capillary intersection_of: BFO:0000050 UBERON:0000948 ! part of heart property_value: skos:prefLabel "coronary capillary" xsd:string [Term] id: UBERON:0006984 name: anatomical surface def: "A two dimensional anatomical structure that is the boundary between an anatomical structure and an anatomical substance, an anatomical space or the organism's environment. Examples include the surface of your skin, the surface of the lining of your gut; the surface of the endothelium of you aorta that is in contact with blood.n." [CARO:0001002] comment: Old definition: 'Non-material anatomical entity of two dimensions, that is demarcated by anatomical lines or points on the external or internal surfaces of anatomical structures.' Note, in the new definition, the space referred to is not necessarily an anatomical space. It may be the outside of an organism. subset: upper_level xref: BILA:0000010 xref: CARO:0001002 xref: EHDAA2_RETIRED:0003192 xref: FMA:24137 xref: NCIT:C34022 xref: UMLS:C1515977 {source="ncithesaurus:Anatomic_Surface"} is_a: UBERON:0010199 ! bona-fide anatomical boundary property_value: skos:prefLabel "anatomical surface" xsd:string [Term] id: UBERON:0007005 name: cardiogenic splanchnic mesoderm def: "The splanchnic mesoderm in the cardiogenic region where the heart develops; it gives rise to endocardial heart tubes that fuse to form the primordial cardiac tube, the heart primordium[web]. Two migratory heart primordia that move ventrally during the course of neurulation, and then fuse[XAO]." [http://www.drugs.com/dict/cardiogenic-mesoderm.html, https://github.com/obophenotype/insect_neuroanatomy_ontology/issues/7, XAO:0000235] subset: efo_slim subset: pheno_slim synonym: "cardiac mesoderm" RELATED [XAO:0000235] synonym: "cardiogenic mesoderm" RELATED [http://www.drugs.com/dict/cardiogenic-mesoderm.html] synonym: "cardiogenic region" RELATED [http://orcid.org/0000-0002-6601-2165] synonym: "cardiogenic splanchnopleure" EXACT [EHDAA2:0000214] synonym: "heart primordia" RELATED [XAO:0000235] xref: AAO:0011021 xref: BILA:0000051 xref: EFO:0000315 xref: EHDAA2:0000214 xref: EHDAA:385 xref: FMA:293143 xref: SCTID:360387000 xref: VHOG:0001641 xref: XAO:0000235 is_a: BFO:0000002 is_a: UBERON:0005291 ! embryonic tissue relationship: BFO:0000050 UBERON:0004140 ! part of primary heart field relationship: BFO:0000050 UBERON:0009881 ! part of anterior lateral plate mesoderm relationship: RO:0002202 UBERON:0004872 ! develops from splanchnic layer of lateral plate mesoderm relationship: RO:0002256 UBERON:0009881 ! developmentally induced by anterior lateral plate mesoderm property_value: IAO:0000116 "consider FBbt:00005541 ! cardiogenic mesoderm" xsd:string property_value: IAO:0000116 "review EHDAA2 placement" xsd:string property_value: skos:prefLabel "cardiogenic splanchnic mesoderm" xsd:string [Term] id: UBERON:0007010 name: cleaving embryo def: "Organism at the cleavage stage." [OBOL:automatic] xref: BILA:0000058 is_a: UBERON:0000922 ! embryo intersection_of: UBERON:0000468 ! multicellular organism intersection_of: RO:0002489 UBERON:0000107 ! existence starts with cleavage stage intersection_of: RO:0002493 UBERON:0000107 ! existence ends with cleavage stage relationship: RO:0002489 UBERON:0000107 ! existence starts with cleavage stage relationship: RO:0002493 UBERON:0000107 ! existence ends with cleavage stage property_value: skos:prefLabel "cleaving embryo" xsd:string [Term] id: UBERON:0007021 name: sexually immature organism def: "A multicellular organism that is at the juvenile stage." [OBOL:automatic] synonym: "juvenile" BROAD [] synonym: "juvenile organism" EXACT [BILA:0000076] synonym: "juveniles" EXACT OMO:0003004 [TAO:0002047] xref: BILA:0000076 xref: http://neurolex.org/wiki/Category\:Juvenile_organism xref: TAO:0002047 is_a: UBERON:0000468 ! multicellular organism intersection_of: UBERON:0000468 ! multicellular organism intersection_of: RO:0002489 UBERON:0000112 ! existence starts with sexually immature stage intersection_of: RO:0002493 UBERON:0000112 ! existence ends with sexually immature stage relationship: RO:0000086 PATO:0001190 ! has quality juvenile relationship: RO:0002489 UBERON:0000112 ! existence starts with sexually immature stage relationship: RO:0002493 UBERON:0000112 ! existence ends with sexually immature stage [Term] id: UBERON:0007023 name: adult organism def: "A multicellular organism that existence_ends_with a post-juvenile adult stage and existence_starts_with a post-juvenile adult stage." [OBOL:automatic] synonym: "adult" BROAD [] synonym: "adults" EXACT OMO:0003004 [TAO:0002046] xref: BILA:0000078 xref: FBbt:00003004 {sssom:mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"} xref: galen:Adult xref: HAO:0000087 xref: http://neurolex.org/wiki/Category\:Adult_organism xref: NCIT:C17600 xref: TAO:0002046 xref: UMLS:C0001675 {source="ncithesaurus:Adult"} is_a: UBERON:0000468 ! multicellular organism intersection_of: UBERON:0000468 ! multicellular organism intersection_of: RO:0002489 UBERON:0000113 ! existence starts with post-juvenile adult stage intersection_of: RO:0002493 UBERON:0000113 ! existence ends with post-juvenile adult stage relationship: RO:0002489 UBERON:0000113 ! existence starts with post-juvenile adult stage relationship: RO:0002493 UBERON:0000113 ! existence ends with post-juvenile adult stage [Term] id: UBERON:0007026 name: presumptive gut synonym: "embryonic digestive tube" RELATED [] synonym: "future digestive tract" EXACT [] synonym: "future digestive tube" EXACT [] synonym: "future gut" EXACT [] synonym: "primitive gut" EXACT [] synonym: "primordial digestive tube" RELATED [] synonym: "primordial gut" RELATED [] xref: BILA:0000084 xref: NCIT:C34268 xref: SCTID:360394002 xref: UMLS:C1514442 {source="ncithesaurus:Primordial_Gut"} is_a: BFO:0000002 is_a: UBERON:0006598 ! presumptive structure intersection_of: UBERON:0006598 ! presumptive structure intersection_of: RO:0002387 UBERON:0001555 ! has potential to develop into digestive tract relationship: RO:0002254 UBERON:0000925 ! has developmental contribution from endoderm relationship: RO:0002254 UBERON:0000926 ! has developmental contribution from mesoderm relationship: RO:0002387 UBERON:0001555 ! has potential to develop into digestive tract relationship: RO:0002488 UBERON:0000109 ! existence starts during gastrula stage property_value: skos:prefLabel "presumptive gut" xsd:string [Term] id: UBERON:0007037 name: mechanosensory system xref: BILA:0000142 is_a: UBERON:0001032 ! sensory system intersection_of: UBERON:0001032 ! sensory system intersection_of: RO:0002215 GO:0050954 ! capable of sensory perception of mechanical stimulus relationship: RO:0002215 GO:0050954 ! capable of sensory perception of mechanical stimulus property_value: skos:prefLabel "mechanosensory system" xsd:string [Term] id: UBERON:0007098 name: mandibular neural crest def: "Cranial neural crest that migrates into the mandibular arch." [ZFA:0007064] xref: TAO:0007064 xref: XAO:0000024 xref: ZFA:0007064 is_a: UBERON:0003099 {source="ZFA"} ! cranial neural crest relationship: BFO:0000050 UBERON:0003852 {source="ZFA"} ! part of rhombencephalon neural crest property_value: skos:prefLabel "mandibular neural crest" xsd:string [Term] id: UBERON:0007099 name: hyoid neural crest def: "Cranial neural crest that migrates into the hyoid arch." [ZFA:0007065] synonym: "hyoid crest" EXACT [XAO:0000025] xref: TAO:0007065 xref: XAO:0000025 xref: ZFA:0007065 is_a: UBERON:0003099 {source="ZFA"} ! cranial neural crest relationship: BFO:0000050 UBERON:0003852 {source="ZFA"} ! part of rhombencephalon neural crest property_value: skos:prefLabel "hyoid neural crest" xsd:string [Term] id: UBERON:0007100 name: primary circulatory organ def: "A hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood or analogs[GO,modified]." [GO:0007507] comment: Gene notes: Bmp, Nkx, Gata subset: grouping_class synonym: "adult heart" RELATED [FBbt:00003154] synonym: "dorsal tube" NARROW [Wikipedia:Heart] synonym: "heart" NARROW [GO:0007507] xref: http://www.sciencemag.org/content/313/5795/1922/F1.large.jpg xref: TADS:0000147 is_a: UBERON:0015228 ! circulatory organ intersection_of: UBERON:0015228 ! circulatory organ intersection_of: RO:0002215 GO:0008015 ! capable of blood circulation relationship: BFO:0000051 CL:0002494 ! has part cardiocyte relationship: RO:0002215 GO:0008015 ! capable of blood circulation property_value: skos:prefLabel "primary circulatory organ" xsd:string [Term] id: UBERON:0007106 name: chorionic villus def: "One of the minute vascular projections of the fetal chorion that combines with maternal uterine tissue to form the placenta." [BTO:0001161, Wikipedia:Chorionic_villi] synonym: "chorionic villi" RELATED OMO:0003004 [MESH:A16.254.403.473.200] synonym: "chorionic villous" RELATED [Wikipedia:Chorionic_villi] synonym: "chorionic villus" RELATED [GAID:1300] synonym: "embryonic part of placenta" RELATED [http://orcid.org/0000-0002-6601-2165] synonym: "embryonic placenta" RELATED [http://orcid.org/0000-0002-6601-2165] synonym: "fetal part of placenta" RELATED [http://orcid.org/0000-0002-6601-2165] synonym: "fetal placenta" RELATED [http://orcid.org/0000-0002-6601-2165] synonym: "placental villi" RELATED OMO:0003004 [GAID:1300] synonym: "placental villous" RELATED [] synonym: "placental villus" RELATED [GAID:1300] synonym: "villous chorion" RELATED [] synonym: "villous of placenta" RELATED [] xref: BTO:0001161 xref: EHDAA2:0004717 xref: MESH:D002824 xref: NCIT:C34125 xref: SCTID:360403003 xref: UMLS:C0008508 {source="ncithesaurus:Chorionic_Villus"} xref: Wikipedia:Chorionic_villi is_a: BFO:0000002 is_a: UBERON:0000478 ! extraembryonic structure is_a: UBERON:0002050 ! embryonic structure relationship: BFO:0000050 UBERON:0003124 {source="BTO"} ! part of chorion membrane relationship: RO:0002202 UBERON:0004027 {source="MP-def"} ! develops from chorionic plate property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/1/1e/Gray29.png" xsd:anyURI [Term] id: UBERON:0007119 name: neck of femur def: "The femur neck or neck of the femur is a flattened pyramidal process of bone, connecting the femoral head with the femoral shaft, and forming with the latter a wide angle opening medialward." [Wikipedia:Femur_neck] subset: human_reference_atlas subset: pheno_slim synonym: "collum femoris" RELATED OMO:0003011 [Wikipedia:Femur_neck] synonym: "femoral neck" EXACT [FMA:42385] synonym: "femur neck" RELATED [Wikipedia:Femur_neck] synonym: "neck of the femur" RELATED [Wikipedia:Femur_neck] xref: FMA:42385 xref: GAID:201 xref: galen:NeckOfFemur xref: MESH:D005272 xref: NCIT:C61563 xref: SCTID:361792007 xref: UMLS:C0015815 {source="ncithesaurus:Femoral_Neck"} xref: Wikipedia:Femur_neck is_a: UBERON:0005055 ! zone of long bone is_a: UBERON:0018664 ! neck of bone element intersection_of: UBERON:0001560 ! neck of organ intersection_of: BFO:0000050 UBERON:0000981 ! part of femur relationship: BFO:0000050 UBERON:0006863 ! part of proximal metaphysis of femur property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/9/97/Gray243.png" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0007122 name: pharyngeal pouch 1 def: "A pharyngeal pouch that is between pharyngeal arches 1 and 2." [ISBN:0124020607, PMID:16313389, VHOG:0000970] subset: efo_slim subset: pheno_slim subset: vertebrate_core synonym: "1st arch branchial pouch" EXACT [EHDAA2:0000013] synonym: "1st arch branchial pouch endoderm" EXACT [EHDAA2:0000016] synonym: "1st arch pouch endoderm" EXACT [EHDAA2:0000016] synonym: "1st branchial pouch" EXACT [] synonym: "1st pharyngeal pouch endoderm" EXACT [VHOG:0000555] synonym: "first arch pharyngeal pouch" EXACT [OBOL:automatic] synonym: "first pharyngeal pouch" RELATED [VHOG:0000970] synonym: "first visceral pouch" EXACT [XAO:0000102] synonym: "hyomandibular pouch" EXACT [] synonym: "pharyngeal pouches 1" EXACT OMO:0003004 [ZFA:0001128] synonym: "visceral pouch 1" EXACT [XAO:0000102] xref: AAO:0011114 xref: EFO:0003631 xref: EHDAA2:0000016 xref: EMAPA:16124 xref: EMAPA:16125 xref: FMA:295668 xref: NCIT:C34176 xref: SCTID:345248006 xref: TAO:0001128 xref: UMLS:C0231068 {source="ncithesaurus:First_Pharyngeal_Pouch"} xref: VHOG:0000555 xref: VHOG:0000970 xref: Wikipedia:Pharyngeal_pouch_(embryology)#First_pouch xref: XAO:0000102 xref: ZFA:0001128 is_a: UBERON:0004117 ! pharyngeal pouch intersection_of: UBERON:0004117 ! pharyngeal pouch intersection_of: RO:0002131 UBERON:0003066 ! overlaps pharyngeal arch 2 intersection_of: RO:0002131 UBERON:0004362 ! overlaps pharyngeal arch 1 relationship: RO:0002131 UBERON:0003066 ! overlaps pharyngeal arch 2 relationship: RO:0002131 UBERON:0004362 ! overlaps pharyngeal arch 1 property_value: skos:prefLabel "pharyngeal pouch 1" xsd:string [Term] id: UBERON:0007123 name: pharyngeal pouch 2 def: "A pharyngeal puch that is between the pharyngeal arches 2 and 3." [ISBN:0124020607, PMID:16313389] subset: efo_slim subset: pheno_slim subset: vertebrate_core synonym: "2nd arch branchial pouch" EXACT [RETIRED_EHDAA2:0000060] synonym: "2nd arch branchial pouch endoderm" EXACT [EHDAA2:0000061] synonym: "2nd arch pouch endoderm" EXACT [EHDAA2:0000058] synonym: "2nd branchial pouch" EXACT [] synonym: "2nd pharyngeal pouch endoderm" EXACT [VHOG:0000561] synonym: "pharyngeal pouches 2" EXACT OMO:0003004 [ZFA:0001130] synonym: "second arch pharyngeal pouch" EXACT [OBOL:automatic] synonym: "second pharyngeal pouch" RELATED [VHOG:0000967] synonym: "second visceral pouch" EXACT [XAO:0000247] synonym: "visceral pouch 2" EXACT [XAO:0000247] xref: AAO:0011115 xref: EFO:0003633 xref: EHDAA2:0000058 xref: EMAPA:16275 xref: FMA:295676 xref: NCIT:C34289 xref: RETIRED_EHDAA2:0000060 xref: SCTID:345349000 xref: TAO:0001130 xref: UMLS:C0231069 {source="ncithesaurus:Second_Pharyngeal_Pouch"} xref: VHOG:0000561 xref: VHOG:0000967 xref: Wikipedia:Pharyngeal_pouch_(embryology)#Second_pouch xref: XAO:0000247 xref: ZFA:0001130 is_a: UBERON:0004117 ! pharyngeal pouch intersection_of: UBERON:0004117 ! pharyngeal pouch intersection_of: RO:0002131 UBERON:0003066 ! overlaps pharyngeal arch 2 intersection_of: RO:0002131 UBERON:0003114 ! overlaps pharyngeal arch 3 relationship: RO:0002131 UBERON:0003066 ! overlaps pharyngeal arch 2 relationship: RO:0002131 UBERON:0003114 ! overlaps pharyngeal arch 3 property_value: skos:prefLabel "pharyngeal pouch 2" xsd:string [Term] id: UBERON:0007124 name: pharyngeal pouch 3 def: "A pharyngeal pouch that between pharyngeal arches 3 and 4." [ISBN:0124020607, PMID:16313389, Wikipedia:Pharyngeal_pouch_(embryology)#Third_pouch] subset: efo_slim subset: pheno_slim subset: vertebrate_core synonym: "3rd arch branchial pouch" EXACT [RETIRED_EHDAA2:0000076] synonym: "3rd arch branchial pouch endoderm" EXACT [EHDAA2:0000077] synonym: "3rd branchial pouch" EXACT [] synonym: "3rd pharyngeal pouch endoderm" EXACT [VHOG:0001030] synonym: "pharyngeal pouches 3" EXACT OMO:0003004 [ZFA:0001131] synonym: "third arch pharyngeal pouch" EXACT [OBOL:automatic] synonym: "third pharyngeal pouch" RELATED [VHOG:0000966] synonym: "third visceral pouch" EXACT [XAO:0000251] synonym: "visceral pouch 3" EXACT [XAO:0000251] xref: AAO:0011116 xref: EFO:0003634 xref: EHDAA2:0000077 xref: EMAPA:16586 xref: FMA:295682 xref: NCIT:C34311 xref: RETIRED_EHDAA2:0000076 xref: SCTID:345450001 xref: TAO:0001131 xref: UMLS:C0231070 {source="ncithesaurus:Third_Pharyngeal_Pouch"} xref: VHOG:0000966 xref: VHOG:0001030 xref: Wikipedia:Pharyngeal_pouch_(embryology)#Third_pouch xref: XAO:0000251 xref: ZFA:0001131 is_a: UBERON:0004117 ! pharyngeal pouch intersection_of: UBERON:0004117 ! pharyngeal pouch intersection_of: RO:0002131 UBERON:0003114 ! overlaps pharyngeal arch 3 intersection_of: RO:0002131 UBERON:0003115 ! overlaps pharyngeal arch 4 relationship: RO:0002131 UBERON:0003114 ! overlaps pharyngeal arch 3 relationship: RO:0002131 UBERON:0003115 ! overlaps pharyngeal arch 4 property_value: skos:prefLabel "pharyngeal pouch 3" xsd:string [Term] id: UBERON:0007125 name: pharyngeal pouch 4 def: "A pharyngeal pouch between pharyngeal arch 4 and arch 5 or 6 (a fifth arch never establishes in amniotes)." [ISBN:0124020607, PMID:16313389, Wikipedia:Pharyngeal_pouch_(embryology)#Fourth_pouch] subset: efo_slim subset: pheno_slim subset: vertebrate_core synonym: "4th arch branchial pouch" EXACT [RETIRED_EHDAA2:0000090] synonym: "4th arch branchial pouch endoderm" EXACT [EHDAA2:0000091] synonym: "4th branchial pouch" EXACT [] synonym: "4th pharyngeal pouch endoderm" EXACT [VHOG:0000578] synonym: "fourth arch pharyngeal pouch" EXACT [OBOL:automatic] synonym: "fourth branchial pouch" EXACT [] synonym: "fourth pharyngeal pouch" RELATED [VHOG:0000971] synonym: "fourth visceral pouch" EXACT [XAO:0000254] synonym: "pharyngeal pouches 4" EXACT OMO:0003004 [ZFA:0001134] synonym: "visceral pouch 4" EXACT [XAO:0000254] xref: AAO:0011117 xref: EFO:0003637 xref: EHDAA2:0000091 xref: EMAPA:16766 xref: FMA:295688 xref: NCIT:C34181 xref: RETIRED_EHDAA2:0000090 xref: SCTID:362858001 xref: TAO:0001134 xref: UMLS:C0231071 {source="ncithesaurus:Fourth_Pharyngeal_Pouch"} xref: VHOG:0000578 xref: VHOG:0000971 xref: Wikipedia:Pharyngeal_pouch_(embryology)#Fourth_pouch xref: XAO:0000254 xref: ZFA:0001134 is_a: UBERON:0004117 ! pharyngeal pouch intersection_of: UBERON:0004117 ! pharyngeal pouch intersection_of: RO:0002131 UBERON:0003115 ! overlaps pharyngeal arch 4 intersection_of: RO:0002131 UBERON:0003116 ! overlaps pharyngeal arch 5 relationship: RO:0002131 UBERON:0003115 ! overlaps pharyngeal arch 4 relationship: RO:0002131 UBERON:0003116 ! overlaps pharyngeal arch 5 [Term] id: UBERON:0007128 name: glomeral mesenchyme def: "Portion of tissue that consists of the precursors of the pronephric glomus or glomerulus; derived from the medial portion of the pronephric intermediate mesoderm." [ISBN:0815318960] synonym: "corpuscle" RELATED [XAO:0000110] synonym: "glomerulus" RELATED [XAO:0000110] xref: XAO:0000110 is_a: BFO:0000002 is_a: UBERON:0002050 ! embryonic structure relationship: RO:0002202 UBERON:0003064 ! develops from intermediate mesoderm [Term] id: UBERON:0007134 name: trunk ganglion def: "Ganglion which is located in the trunk." [ZFIN:curator] subset: efo_slim synonym: "body ganglion" EXACT [MAT:0000344] synonym: "trunk ganglia" EXACT OMO:0003004 [ZFA:0001573] xref: EFO:0000901 xref: MAT:0000344 xref: MIAA:0000344 xref: TAO:0001573 xref: ZFA:0001573 is_a: UBERON:0000045 ! ganglion intersection_of: UBERON:0000045 ! ganglion intersection_of: BFO:0000050 UBERON:0002100 ! part of trunk relationship: BFO:0000050 UBERON:0002100 ! part of trunk property_value: skos:prefLabel "trunk ganglion" xsd:string [Term] id: UBERON:0007135 name: neural keel def: "An intermediate stage (between the neural plate and neural rod) during the early segmentation period in the morphogenesis of the central nervous system primordium; the keel is roughly triangular shaped in cross section." [ZFIN:ZDB-PUB-961014-576] subset: efo_slim synonym: "presumptive central nervous system" RELATED [ZFA:0000131] xref: EFO:0003497 xref: TAO:0000131 xref: ZFA:0000131 is_a: UBERON:0016879 ! future central nervous system relationship: RO:0002202 UBERON:0003075 ! develops from neural plate property_value: skos:prefLabel "neural keel" xsd:string [Term] id: UBERON:0007142 name: left internal carotid artery def: "An internal carotid artery that branching_part_of a left common carotid artery plus branches." [OBOL:automatic] synonym: "arteria caritis interna sinistra" EXACT [FMA:4062] xref: EMAPA:16329 xref: FMA:4062 xref: SCTID:161452006 is_a: UBERON:0001532 ! internal carotid artery intersection_of: UBERON:0001532 ! internal carotid artery intersection_of: RO:0002380 UBERON:0001536 ! branching part of left common carotid artery plus branches relationship: RO:0002380 UBERON:0001536 ! branching part of left common carotid artery plus branches property_value: skos:prefLabel "left internal carotid artery" xsd:string [Term] id: UBERON:0007143 name: right internal carotid artery def: "An internal carotid artery that branching_part_of a right common carotid artery plus branches." [OBOL:automatic] synonym: "arteria carotis interna dextra" EXACT [FMA:3949] xref: EMAPA:16330 xref: FMA:3949 xref: SCTID:161251001 is_a: UBERON:0001532 ! internal carotid artery intersection_of: UBERON:0001532 ! internal carotid artery intersection_of: RO:0002380 UBERON:0001531 ! branching part of right common carotid artery plus branches relationship: RO:0002380 UBERON:0001531 ! branching part of right common carotid artery plus branches property_value: skos:prefLabel "right internal carotid artery" xsd:string [Term] id: UBERON:0007144 name: embryonic post-anal tail def: "An embryonic structure that will either develop into a post-anal tail or recede into a vestigial remnant of the tail." [http://orcid.org/0000-0002-6601-2165] synonym: "embryo tail" EXACT [FMA:85540] synonym: "embryonic tail" RELATED [FMA:85540] synonym: "tail of embryo" EXACT [FMA:85540] xref: EMAPA:16748 xref: FMA:85540 is_a: BFO:0000002 is_a: UBERON:0002050 ! embryonic structure relationship: RO:0002494 UBERON:0002533 ! transformation of post-anal tail bud property_value: skos:prefLabel "embryonic post-anal tail" xsd:string [Term] id: UBERON:0007147 name: lumen of midgut def: "An anatomical cavity that surrounded_by a midgut." [OBOL:automatic] synonym: "midgut lumen" EXACT [FMA:54366] xref: EMAPA:18377 xref: FMA:54366 is_a: UBERON:0000464 ! anatomical space intersection_of: UBERON:0000464 ! anatomical space intersection_of: RO:0002572 UBERON:0001045 ! luminal space of midgut relationship: RO:0002572 UBERON:0001045 ! luminal space of midgut property_value: skos:prefLabel "lumen of midgut" xsd:string [Term] id: UBERON:0007148 name: lumen of hindgut def: "An anatomical cavity that surrounded_by a hindgut." [OBOL:automatic] synonym: "hindgut lumen" EXACT [FMA:54367] xref: EMAPA:18396 xref: FMA:54367 is_a: UBERON:0000464 ! anatomical space intersection_of: UBERON:0000464 ! anatomical space intersection_of: RO:0002572 UBERON:0001046 ! luminal space of hindgut relationship: RO:0002572 UBERON:0001046 ! luminal space of hindgut property_value: skos:prefLabel "lumen of hindgut" xsd:string [Term] id: UBERON:0007158 name: lumen of anal canal def: "An anatomical cavity that surrounded_by a anal canal." [OBOL:automatic] synonym: "anal canal lumen" EXACT [FMA:17357] xref: EMAPA:18836 xref: FMA:17357 is_a: UBERON:0000464 ! anatomical space intersection_of: UBERON:0000464 ! anatomical space intersection_of: RO:0002572 UBERON:0000159 ! luminal space of anal canal relationship: RO:0002572 UBERON:0000159 ! luminal space of anal canal property_value: skos:prefLabel "lumen of anal canal" xsd:string [Term] id: UBERON:0007159 name: lumen of colon def: "An anatomical cavity that surrounded_by a colon." [OBOL:automatic] synonym: "colon lumen" EXACT [FMA:18374] synonym: "colonic lumen" RELATED [FMA:18374] xref: EMAPA:18945 xref: FMA:18374 xref: SCTID:362156004 is_a: UBERON:0000464 ! anatomical space intersection_of: UBERON:0000464 ! anatomical space intersection_of: RO:0002572 UBERON:0001155 ! luminal space of colon relationship: RO:0002572 UBERON:0001155 ! luminal space of colon property_value: skos:prefLabel "lumen of colon" xsd:string [Term] id: UBERON:0007160 name: inferior petrosal sinus def: "The inferior petrosal sinus, within the human head, is an area beneath the brain, which allows blood veins to span the area, from the center of the head downward. It drains from the cavernous sinus (beneath the brain) to the sigmoid sinuses above the internal jugular vein." [Wikipedia:Inferior_petrosal_sinus] subset: human_reference_atlas synonym: "sinus petrosal inferior" EXACT [FMA:50770] xref: EMAPA:19234 xref: FMA:50770 xref: SCTID:279263009 xref: Wikipedia:Inferior_petrosal_sinus is_a: UBERON:0017635 {source="FMA"} ! paired venous dural sinus relationship: RO:0002170 UBERON:0001586 ! connected to internal jugular vein property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0007171 name: border of scapula synonym: "scapular border" EXACT [FMA:23797] xref: EMAPA:25124 xref: FMA:23797 is_a: UBERON:0036304 ! anatomical border intersection_of: UBERON:0036304 ! anatomical border intersection_of: BFO:0000050 UBERON:0006849 ! part of scapula relationship: BFO:0000050 UBERON:0006849 ! part of scapula [Term] id: UBERON:0007172 name: angle of scapula synonym: "scapular angle" EXACT [FMA:23800] xref: EMAPA:25125 xref: FMA:23800 is_a: UBERON:0005913 ! zone of bone organ relationship: BFO:0000050 UBERON:0006849 ! part of scapula property_value: seeAlso "https://github.com/obophenotype/uberon/issues/58" xsd:anyURI [Term] id: UBERON:0007173 name: lateral border of scapula def: "The lateral border (or axillary border, or margin) is the thickest of the three borders of the scapula. It begins above at the lower margin of the glenoid cavity, and inclines obliquely downward and backward to the inferior angle. Immediately below the glenoid cavity is a rough impression, the infraglenoid tuberosity, about 2.5 cm. in length, which gives origin to the long head of the Triceps brachii; in front of this is a longitudinal groove, which extends as far as the lower third of this border, and affords origin to part of the Subscapularis. The inferior third is thin and sharp, and serves for the attachment of a few fibers of the Teres major behind, and of the Subscapularis in front." [Wikipedia:Lateral_border_of_the_scapula] subset: human_reference_atlas synonym: "axillary border of scapula" EXACT [FMA:23239] synonym: "lateral border of scapula" EXACT [FMA:23239] synonym: "lateral part of scapula" RELATED [FMA:23239] synonym: "margo lateralis (scapula)" EXACT [FMA:23239] synonym: "margo lateralis scapulae" EXACT OMO:0003011 [FMA:23239, FMA:TA] xref: EMAPA:25126 xref: FMA:23239 xref: Wikipedia:Lateral_border_of_the_scapula is_a: UBERON:0007171 {source="EMAPA-modified"} ! border of scapula disjoint_from: UBERON:0007174 {source="lexical"} ! medial border of scapula property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0007174 name: medial border of scapula def: "The medial border of the scapula (vertebral border, medial margin) is the longest of the three borders, and extends from the medial to the inferior angle. It is arched, intermediate in thickness between the superior and the axillary borders, and the portion of it above the spine forms an obtuse angle with the part below. This border presents an anterior and a posterior lip, and an intermediate narrow area. The anterior lip affords attachment to the Serratus anterior; the posterior lip, to the Supraspinatus above the spine, the Infraspinatus below; the area between the two lips, to the Levator scapulC& above the triangular surface at the commencement of the spine, to the Rhomboideus minor on the edge of that surface, and to the Rhomboideus major below it; this last is attached by means of a fibrous arch, connected above to the lower part of the triangular surface at the base of the spine, and below to the lower part of the border." [Wikipedia:Medial_border_of_scapula] subset: human_reference_atlas synonym: "margo medialis (scapula)" EXACT [FMA:23242] synonym: "margo medialis scapulae" EXACT OMO:0003011 [FMA:23242, FMA:TA] synonym: "medial border of the scapula" RELATED [Wikipedia:Medial_border_of_scapula] synonym: "medial margin of the scapula" RELATED [Wikipedia:Medial_border_of_scapula] synonym: "medial part of scapula" EXACT [FMA:23242] synonym: "vertebral border" RELATED [Wikipedia:Medial_border_of_scapula] synonym: "vertebral border of scapula" EXACT [FMA:23242] synonym: "vertebral border of the scapula" RELATED [Wikipedia:Medial_border_of_scapula] xref: EMAPA:25127 xref: FMA:23242 xref: SCTID:368187009 xref: Wikipedia:Medial_border_of_scapula is_a: BFO:0000002 is_a: UBERON:0007171 {source="EMAPA-modified"} ! border of scapula relationship: RO:0002254 UBERON:0002329 {source="PMID:20136669"} ! has developmental contribution from somite property_value: IAO:0000116 "consider merging with UBERON:1500000 scapular blade, depending on https://github.com/obophenotype/uberon/issues/339. See also http://www.ncbi.nlm.nih.gov/pubmed/20136669" xsd:string property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0007175 name: inferior angle of scapula def: "An angle of the scapula formed by the union of the vertebral and axillary borders; its dorsal surface affords attachment to the Teres major and frequently to a few fibers of the Latissimus dorsi.[WP,unvetted]." [Wikipedia:Inferior_angle_of_scapula] subset: human_reference_atlas synonym: "angulus inferior (scapula)" EXACT [FMA:13315] synonym: "angulus inferior scapulae" EXACT OMO:0003011 [Wikipedia:Inferior_angle_of_scapula] xref: EMAPA:25128 xref: FMA:13315 xref: Wikipedia:Inferior_angle_of_scapula is_a: UBERON:0007172 {source="EMAPA-modified"} ! angle of scapula property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0007177 name: lamina propria of mucosa of colon def: "A lamina propria that is part of a colonic mucosa." [OBOL:automatic] subset: human_reference_atlas synonym: "colonic lamina propria" EXACT [FMA:15657] synonym: "lamina propria mucosae of colon" EXACT [FMA:15657] synonym: "lamina propria of colonic mucosa" EXACT [FMA:15657] synonym: "lamina propria of colonic mucous membrane" EXACT [FMA:15657] xref: EMAPA:27395 xref: FMA:15657 xref: MA:0003196 xref: SCTID:113284008 is_a: UBERON:0011189 ! lamina propria of large intestine intersection_of: UBERON:0000030 ! lamina propria intersection_of: BFO:0000050 UBERON:0000317 ! part of colonic mucosa relationship: BFO:0000050 UBERON:0000317 ! part of colonic mucosa property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "lamina propria of mucosa of colon" xsd:string [Term] id: UBERON:0007178 name: muscularis mucosae of colon def: "A muscularis mucosa that is part of a colonic mucosa." [OBOL:automatic] subset: human_reference_atlas synonym: "lamina muscularis of colonic mucosa" EXACT [FMA:15656] synonym: "lamina muscularis of colonic mucous membrane" EXACT [FMA:15656] synonym: "muscularis mucosa of colon" EXACT [] xref: EMAPA:27399 xref: FMA:15656 xref: MA:0003197 xref: SCTID:885000 is_a: UBERON:0001239 ! muscularis mucosae of large intestine intersection_of: UBERON:0006676 ! muscularis mucosa intersection_of: BFO:0000050 UBERON:0000317 ! part of colonic mucosa relationship: BFO:0000050 UBERON:0000317 ! part of colonic mucosa property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0007181 name: serosa of infundibulum of uterine tube def: "A serous membrane that is part of a uterine tube infundibulum." [OBOL:automatic] synonym: "serosa of infundibulum of fallopian tube" EXACT [FMA:18324] synonym: "serosa of infundibulum of oviduct" EXACT [FMA:18324] xref: EMAPA:29903 xref: FMA:18324 is_a: UBERON:0000042 ! serous membrane is_a: UBERON:0005156 ! reproductive structure intersection_of: UBERON:0000042 ! serous membrane intersection_of: BFO:0000050 UBERON:0003984 ! part of uterine tube infundibulum relationship: BFO:0000050 UBERON:0003984 ! part of uterine tube infundibulum [Term] id: UBERON:0007182 name: muscle layer of infundibulum of uterine tube def: "A muscle layer that is part of a uterine tube infundibulum." [OBOL:automatic] synonym: "muscle layer of infundibulum of fallopian tube" EXACT [FMA:18336] synonym: "muscle layer of infundibulum of oviduct" EXACT [FMA:18336] synonym: "muscularis of infundibulum of uterine tube" EXACT [FMA:18336] xref: EMAPA:31264 xref: FMA:18336 is_a: UBERON:0005156 ! reproductive structure is_a: UBERON:0006660 ! muscular coat intersection_of: UBERON:0006660 ! muscular coat intersection_of: BFO:0000050 UBERON:0003984 ! part of uterine tube infundibulum relationship: BFO:0000050 UBERON:0003984 ! part of uterine tube infundibulum [Term] id: UBERON:0007188 name: mesothelium of serous pericardium def: "A mesothelium that is part of a serous pericardium." [OBOL:automatic] synonym: "mesothelium of pericardium" EXACT [FMA:18149] synonym: "pericardial mesothelium" EXACT [FMA:18149] synonym: "serous pericardium mesothelium" EXACT [FMA:18149] xref: BTO:0003157 xref: EMAPA:16133 xref: FMA:18149 xref: SCTID:67300002 is_a: UBERON:0003388 ! mesothelium of pericardial cavity intersection_of: UBERON:0001136 ! mesothelium intersection_of: BFO:0000050 UBERON:0002357 ! part of serous pericardium relationship: BFO:0000050 UBERON:0002357 ! part of serous pericardium property_value: skos:prefLabel "mesothelium of serous pericardium" xsd:string [Term] id: UBERON:0007195 name: stroma of bone marrow def: "The stroma of the bone marrow is all tissue not directly involved in the primary function of hematopoiesis. The yellow bone marrow belongs here, and makes the majority of the bone marrow stroma, in addition to stromal cells located in the red bone marrow. Yellow bone marrow is found in the Medullary cavity. Still, the stroma is indirectly involved in hematopoiesis, since it provides the hematopoietic microenvironment that facilitates hematopoiesis by the parenchymal cells. For instance, they generate colony stimulating factors, affecting hematopoiesis." [Wikipedia:Bone_marrow#Stroma] synonym: "bone marrow stroma" EXACT [FMA:21426] xref: CALOHA:TS-0085 xref: FMA:21426 xref: Wikipedia:Bone_marrow#Stroma is_a: BFO:0000002 is_a: UBERON:0003891 ! stroma intersection_of: UBERON:0003891 ! stroma intersection_of: BFO:0000050 UBERON:0002371 ! part of bone marrow relationship: BFO:0000050 UBERON:0002371 ! part of bone marrow relationship: BFO:0000051 CL:0002240 ! has part marrow fibroblast relationship: BFO:0000051 UBERON:0000332 ! has part yellow bone marrow relationship: BFO:0000051 UBERON:0003909 ! has part sinusoid [Term] id: UBERON:0007196 name: tracheobronchial tree def: "The structure from the trachea, bronchi, and bronchioles that forms the airways that supply air to the lungs. The lining of the tracheobronchial tree consists of ciliated columnar epithelial cells." [Wikipedia:Tracheobronchial_tree] subset: human_reference_atlas subset: organ_slim subset: pheno_slim synonym: "arbor tracheobronchialis" EXACT OMO:0003011 [FMA:7393, FMA:TA] synonym: "tracheobronchial system" RELATED [HP:0005607] xref: FMA:7393 xref: NCIT:C117875 xref: SCTID:361384001 xref: Wikipedia:Tracheobronchial_tree is_a: BFO:0000002 is_a: UBERON:0000062 ! organ relationship: BFO:0000050 UBERON:0001558 ! part of lower respiratory tract relationship: BFO:0000051 UBERON:0002185 ! has part bronchus relationship: BFO:0000051 UBERON:0003126 ! has part trachea relationship: BFO:0000051 UBERON:0007592 {source="Wikipedia"} ! has part ciliated columnar epithelium property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "tracheobronchial tree" xsd:string [Term] id: UBERON:0007197 name: hermaphroditic organism def: "Multicellular organism that can produce both male and female gametes." [http://orcid.org/0000-0001-9114-8737] synonym: "dioecious organism" RELATED [BILA:0000029] synonym: "hermaphrodite" RELATED [WBbt:0007849] xref: AAO:0010035 xref: BILA:0000029 xref: CARO:0000029 xref: HAO:0000029 xref: TADS:0000601 xref: WBbt:0007849 is_a: UBERON:0000468 ! multicellular organism [Term] id: UBERON:0007198 name: hermaphrodite anatomical structure def: "An anatomical structure present only in hermaphrodites." [https://orcid.org/0000-0002-4422-9726] synonym: "hermaphrodite-specific" RELATED [WBbt:0005758] xref: AEO:0000177 xref: EHDAA2:0003177 xref: WBbt:0005758 is_a: UBERON:0014402 ! sex-specific anatomical structure intersection_of: UBERON:0014402 ! sex-specific anatomical structure intersection_of: BFO:0000050 UBERON:0007197 ! part of hermaphroditic organism relationship: BFO:0000050 UBERON:0007197 ! part of hermaphroditic organism [Term] id: UBERON:0007204 name: brachiocephalic vasculature def: "The vasculature consisting of brachiocephalic arteries and veins." [http://orcid.org/0000-0002-6601-2165] is_a: UBERON:0002049 ! vasculature property_value: skos:prefLabel "brachiocephalic vasculature" xsd:string [Term] id: UBERON:0007213 name: mesenchyme derived from head neural crest def: "Mesenchyme that develops_from a cranial neural crest." [OBOL:automatic] subset: efo_slim subset: vertebrate_core synonym: "head mesenchyme from cranial neural crest" EXACT [] synonym: "head mesenchyme from neural crest" EXACT [EHDAA2:0000735] synonym: "head neural crest derived mesenchyme" EXACT [] xref: EFO:0003572 xref: EHDAA2:0000735 xref: EMAPA:16169 xref: EMAPA:16271 xref: EMAPA_RETIRED:16271 xref: TAO:0000787 xref: ZFA:0000787 is_a: BFO:0000002 is_a: UBERON:0005253 {source="ZFA"} ! head mesenchyme intersection_of: UBERON:0003104 ! mesenchyme intersection_of: RO:0002202 UBERON:0003099 ! develops from cranial neural crest relationship: RO:0002202 UBERON:0003099 ! develops from cranial neural crest property_value: skos:prefLabel "mesenchyme derived from head neural crest" xsd:string [Term] id: UBERON:0007214 name: mesenchyme derived from trunk neural crest def: "Mesenchyme that develops_from a trunk neural crest." [OBOL:automatic] subset: vertebrate_core synonym: "trunk mesenchyme from neural crest" EXACT [EHDAA2:0002093] synonym: "trunk neural crest derived mesenchyme" EXACT [] xref: EHDAA2:0002093 xref: EMAPA:16182 xref: TAO:0000999 xref: ZFA:0000999 is_a: BFO:0000002 is_a: UBERON:0005256 ! trunk mesenchyme intersection_of: UBERON:0003104 ! mesenchyme intersection_of: RO:0002202 UBERON:0003083 ! develops from trunk neural crest relationship: RO:0002202 UBERON:0003083 ! develops from trunk neural crest property_value: skos:prefLabel "mesenchyme derived from trunk neural crest" xsd:string [Term] id: UBERON:0007220 name: late embryonic stage def: "An embryo stage that covers late steps of the embryogenesis with a fully formed embryo still developing before birth or egg hatching." [https://orcid.org/0000-0003-3308-6245] synonym: "embryo late (growth) stage" EXACT [MIAA:0000399] synonym: "embryo late growth stage" RELATED [BTO:0000449] synonym: "embryo late stage" RELATED [BTO:0000449] synonym: "fetal stage" NARROW SENSU [https://orcid.org/0000-0002-6601-2165] synonym: "fetus" NARROW [MIAA:0000399] synonym: "fetus stage" NARROW SENSU [https://orcid.org/0000-0002-6601-2165] xref: EV:0300011 xref: EVM:2990031 xref: FBdv:00005333 xref: FMA:63631 xref: HsapDv:0000037 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: MIAA:0000399 xref: MmusDv:0000031 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: OGES:000023 xref: RnorDv:0000011 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: SCTID:367619004 xref: SscrDv:0000080 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: BFO:0000003 is_a: UBERON:0000105 ! life cycle stage relationship: BFO:0000050 UBERON:0000068 ! part of embryo stage relationship: BFO:0000062 UBERON:0000111 ! preceded by organogenesis stage property_value: seeAlso "https://github.com/obophenotype/uberon/issues/355" xsd:anyURI property_value: seeAlso "https://github.com/obophenotype/uberon/issues/565" xsd:anyURI [Term] id: UBERON:0007221 name: neonate stage def: "Of or pertaining to the period of time immediately following birth, or to the newborn." [http://en.wiktionary.org/wiki/neonatal, Wikipedia:Infant] synonym: "fledgling stage" NARROW SENSU [https://orcid.org/0000-0002-6601-2165] synonym: "hatchling" NARROW SENSU [https://orcid.org/0000-0002-6601-2165] synonym: "hatchling stage" NARROW SENSU [https://orcid.org/0000-0002-6601-2165] synonym: "infant stage" NARROW SENSU [https://orcid.org/0000-0002-6601-2165] synonym: "neonatal stage" EXACT [OBOL:automatic] synonym: "nestling stage" NARROW SENSU [https://orcid.org/0000-0002-6601-2165] synonym: "newborn stage" RELATED [https://orcid.org/0000-0002-6601-2165] synonym: "pouch stage" NARROW SENSU [NCBITaxon:9263] synonym: "puggle" NARROW SENSU [NCBITaxon:189497] synonym: "puggle stage" NARROW SENSU [NCBITaxon:189497] xref: BTO:0001762 xref: ChirDv:0000017 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: EV:0300037 xref: HsapDv:0000262 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: http://neurolex.org/wiki/Category\:Infant_organism xref: http://neurolex.org/wiki/Category\:Newborn_organism xref: MdomDv:0000004 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: MmulDv:0000046 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: MmusDv:0000036 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: NIF_Organism:birnlex_695 xref: OGES:000025 xref: RnorDv:0000013 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: SscrDv:0000009 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: Wikipedia:Infant is_a: BFO:0000003 is_a: UBERON:0000105 ! life cycle stage relationship: BFO:0000050 UBERON:0000112 ! part of sexually immature stage property_value: IAO:0000116 "consider splitting infant/newborn" xsd:string property_value: seeAlso "https://github.com/obophenotype/uberon/issues/350" xsd:anyURI [Term] id: UBERON:0007223 name: osseus cochlea def: "The osseous cochlea is the bony foundation that forms the small shell arrangement for the cochlear nerve." [http://www.innerbody.com/image_nerv14/nerv175.html] subset: pheno_slim xref: EMAPA:35620 xref: MA:0000239 is_a: UBERON:0000061 ! anatomical structure relationship: BFO:0000050 UBERON:0001844 ! part of cochlea property_value: IAO:0000116 "TODO - check this. in MA, cochlea is not part of the bony labyrinth" xsd:string property_value: skos:prefLabel "osseus cochlea" xsd:string [Term] id: UBERON:0007228 name: vestibular nucleus def: "A cranial nucleus for the vestibular nerve. [WP,unvetted]." [http://www.sciencedirect.com/science/article/pii/S0079612305510069, https://github.com/geneontology/go-ontology/issues/9028, Wikipedia:Vestibular_nuclei] comment: See comments for 'vestibular nuclear complex. subset: human_reference_atlas synonym: "vestibular nucleus of acoustic nerve" EXACT [FMA:54602] synonym: "vestibular nucleus of eighth cranial nerve" EXACT [FMA:54602] synonym: "vestibular VIII nucleus" EXACT [MA:0001032] xref: CALOHA:TS-2078 xref: EMAPA:35923 xref: FMA:54602 xref: MA:0001032 xref: NCIT:C12821 xref: SCTID:362462004 xref: UMLS:C0042600 {source="ncithesaurus:Vestibular_Nucleus"} xref: Wikipedia:Vestibular_nuclei is_a: UBERON:0007635 ! nucleus of medulla oblongata intersection_of: UBERON:0000125 ! neural nucleus intersection_of: BFO:0000050 UBERON:0002673 ! part of vestibular nuclear complex relationship: BFO:0000050 UBERON:0002673 ! part of vestibular nuclear complex relationship: extends_fibers_into UBERON:0003723 ! vestibular nerve property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/5/52/Gray691.png" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "vestibular nucleus" xsd:string [Term] id: UBERON:0007237 name: 1st arch mandibular component synonym: "ventral mandibular arch" RELATED [VHOG:0000510] synonym: "ventral pharyngeal arch 1" EXACT [VHOG:0000510] synonym: "ventral visceral arch 1" RELATED [VHOG:0000510] xref: EHDAA2:0000031 xref: EHDAA:583 xref: EMAPA:16382 xref: VHOG:0000510 is_a: UBERON:0002050 ! embryonic structure relationship: BFO:0000050 UBERON:0004362 {source="EHDAA2"} ! part of pharyngeal arch 1 property_value: IAO:0000116 "relationship to Meckel's cartilage to be added" xsd:string property_value: skos:prefLabel "1st arch mandibular component" xsd:string [Term] id: UBERON:0007238 name: 1st arch maxillary component xref: EHDAA2:0000038 xref: EHDAA:595 xref: EMAPA:16388 is_a: UBERON:0002050 ! embryonic structure relationship: BFO:0000050 UBERON:0004362 {source="EHDAA2"} ! part of pharyngeal arch 1 property_value: IAO:0000116 "relationship to palatoquadrate to be added" xsd:string property_value: skos:prefLabel "1st arch maxillary component" xsd:string [Term] id: UBERON:0007239 name: tunica media of artery def: "A tunica media that is part of a artery." [OBOL:automatic] synonym: "arterial media" EXACT [EV:0100029] synonym: "tunica media (arteriae)" EXACT [FMA:14273] xref: EMAPA:36294 xref: EV:0100029 xref: FMA:14273 xref: NCIT:C49321 xref: SCTID:84300001 xref: UMLS:C1710627 {source="ncithesaurus:Venous_System_Smooth_Muscle_Tissue"} is_a: UBERON:0002522 ! tunica media intersection_of: UBERON:0002522 ! tunica media intersection_of: BFO:0000050 UBERON:0001637 ! part of artery relationship: BFO:0000050 UBERON:0000415 ! part of artery wall property_value: skos:prefLabel "tunica media of artery" xsd:string [Term] id: UBERON:0007240 name: tunica adventitia of artery def: "A tunica adventitia that is part of a artery." [OBOL:automatic] synonym: "arterial adventitia" EXACT [EV:0100030] synonym: "tunica externa (adventitia)(arteriae)" EXACT [FMA:14274] xref: EMAPA:36295 xref: EV:0100030 xref: FMA:14274 xref: SCTID:113261001 is_a: BFO:0000002 is_a: UBERON:0005734 ! tunica adventitia of blood vessel intersection_of: UBERON:0005734 ! tunica adventitia of blood vessel intersection_of: BFO:0000050 UBERON:0001637 ! part of artery relationship: BFO:0000050 UBERON:0000415 ! part of artery wall relationship: BFO:0000051 CL:1000306 {source="FMA"} ! has part fibroblast of tunica adventitia of artery property_value: skos:prefLabel "tunica adventitia of artery" xsd:string [Term] id: UBERON:0007241 name: tunica adventitia of vein def: "A tunica adventitia that is part of a vein." [OBOL:automatic] synonym: "tunica externa (adventitia)(venae)" EXACT [FMA:14355] synonym: "venous adventitia" EXACT [EV:0100034] xref: EMAPA:36310 xref: EV:0100034 xref: FMA:14355 xref: SCTID:13202006 is_a: UBERON:0005734 ! tunica adventitia of blood vessel intersection_of: UBERON:0005734 ! tunica adventitia of blood vessel intersection_of: BFO:0000050 UBERON:0001638 ! part of vein relationship: BFO:0000050 UBERON:0001638 ! part of vein property_value: skos:prefLabel "tunica adventitia of vein" xsd:string [Term] id: UBERON:0007242 name: tunica intima of vein def: "A tunica intima that is part of a vein." [OBOL:automatic] synonym: "tunica interna (intima)(venae)" EXACT [FMA:14353] synonym: "venous intima" EXACT [EV:0100032] xref: EMAPA:36308 xref: EV:0100032 xref: FMA:14353 xref: SCTID:2436009 is_a: UBERON:0002523 ! tunica intima is_a: UBERON:0004797 ! blood vessel layer intersection_of: UBERON:0002523 ! tunica intima intersection_of: BFO:0000050 UBERON:0001638 ! part of vein relationship: BFO:0000050 UBERON:0001638 ! part of vein property_value: skos:prefLabel "tunica intima of vein" xsd:string [Term] id: UBERON:0007243 name: tunica media of vein def: "A tunica media that is part of a vein." [OBOL:automatic] synonym: "tunica media (venae)" EXACT [FMA:14354] synonym: "venous media" EXACT [EV:0100033] xref: EMAPA:36309 xref: EV:0100033 xref: FMA:14354 xref: SCTID:42049001 is_a: UBERON:0002522 ! tunica media intersection_of: UBERON:0002522 ! tunica media intersection_of: BFO:0000050 UBERON:0001638 ! part of vein relationship: BFO:0000050 UBERON:0001638 ! part of vein property_value: skos:prefLabel "tunica media of vein" xsd:string [Term] id: UBERON:0007245 name: nuclear complex of neuraxis def: "Gray matter of the central nervous system which is a collection of clustered nuclei." [http://orcid.org/0000-0002-6601-2165] synonym: "cluster of neural nuclei" RELATED [] synonym: "neural nuclei" RELATED [] synonym: "nuclear complex" RELATED [] xref: FMA:256381 xref: FMA:84059 is_a: UBERON:0002020 ! gray matter intersection_of: UBERON:0002020 ! gray matter intersection_of: RO:0002473 UBERON:0000125 ! composed primarily of neural nucleus relationship: RO:0002473 UBERON:0000125 ! composed primarily of neural nucleus property_value: skos:prefLabel "nuclear complex of neuraxis" xsd:string [Term] id: UBERON:0007247 name: nucleus of superior olivary complex def: "Any of the nuclei that comprise the superior olivary complex (superior olive). This includes both the primary nuclei such as the lateral and medial nuclei, as well as periolivary nuclei." [http://orcid.org/0000-0002-6601-2165] subset: grouping_class subset: pheno_slim synonym: "superior olivary complex nucleus" EXACT [FMA:72246] xref: FMA:72246 xref: SCTID:369024009 is_a: UBERON:0006331 ! brainstem nucleus is_a: UBERON:0009662 ! hindbrain nucleus intersection_of: UBERON:0002308 ! nucleus of brain intersection_of: BFO:0000050 UBERON:0002128 ! part of superior olivary complex relationship: BFO:0000050 UBERON:0002128 ! part of superior olivary complex property_value: skos:prefLabel "nucleus of superior olivary complex" xsd:string [Term] id: UBERON:0007251 name: preoptic nucleus def: "A nucleus of brain that is part of a preoptic area." [OBOL:automatic] xref: CALOHA:TS-0822 xref: EV:0100226 xref: MESH:D011301 {sssom:mapping_justification="https://w3id.org/semapv/vocab/LexicalMatching"} is_a: UBERON:0006569 ! diencephalic nucleus intersection_of: UBERON:0002308 ! nucleus of brain intersection_of: BFO:0000050 UBERON:0001928 ! part of preoptic area relationship: BFO:0000050 UBERON:0001928 ! part of preoptic area property_value: RO:0002175 NCBITaxon:117569 {source="Hardisty, p. 320-1"} property_value: skos:prefLabel "preoptic nucleus" xsd:string [Term] id: UBERON:0007252 name: intervertebral disk of cervical vertebra def: "An intervertebral disk that is part of a cervical region of vertebral column. A cervical intervertebral disk connects at least one cervical vertebra, either to another cervical vertebra, or at one point on the vertebral colummn, to a thoracic vertebra." [http://orcid.org/0000-0002-6601-2165] synonym: "cervical intervertebral disc" EXACT [FMA:13895] synonym: "intervertebral disc of cervical region" EXACT [EMAPA:19415] xref: EMAPA:19415 xref: FMA:13895 xref: SCTID:68818006 is_a: UBERON:0001066 ! intervertebral disk is_a: UBERON:0003601 ! neck cartilage is_a: UBERON:0005174 ! dorsal region element is_a: UBERON:2001457 ! postcranial axial cartilage intersection_of: UBERON:0001066 ! intervertebral disk intersection_of: BFO:0000050 UBERON:0006072 ! part of cervical region of vertebral column relationship: BFO:0000050 UBERON:0006072 ! part of cervical region of vertebral column [Term] id: UBERON:0007254 name: intervertebral disk of thoracic vertebra def: "An intervertebral disk that is part of a thoracic region of vertebral column. A thoracic intervertebral disk connects at least one thoracic vertebra, either to another thoracic vertebra, or at one point on the vertebral colummn, to a lumbar vertebra." [http://orcid.org/0000-0002-6601-2165] synonym: "intervertebral disc of thoracic region" EXACT [EMAPA:19489] xref: EMAPA:19489 xref: FMA:10455 is_a: UBERON:0001066 ! intervertebral disk is_a: UBERON:0005174 ! dorsal region element is_a: UBERON:0005181 ! thoracic segment organ is_a: UBERON:2001457 ! postcranial axial cartilage intersection_of: UBERON:0001066 ! intervertebral disk intersection_of: BFO:0000050 UBERON:0006073 ! part of thoracic region of vertebral column relationship: BFO:0000050 UBERON:0006073 ! part of thoracic region of vertebral column [Term] id: UBERON:0007255 name: intervertebral disk of lumbar vertebra def: "An intervertebral disk that is part of a lumbar region of vertebral column. A lumbar intervertebral disk connects at least one lumbar vertebra, either to another thoracic vertebra, or at one point on the vertebral colummn, to a sacral vertebra." [http://orcid.org/0000-0002-6601-2165] synonym: "intervertebral disc of lumbar region" EXACT [EMAPA:19468] xref: EMAPA:19468 xref: FMA:13894 is_a: UBERON:0001066 ! intervertebral disk is_a: UBERON:0005173 ! abdominal segment element is_a: UBERON:0005174 ! dorsal region element is_a: UBERON:2001457 ! postcranial axial cartilage intersection_of: UBERON:0001066 ! intervertebral disk intersection_of: BFO:0000050 UBERON:0006074 ! part of lumbar region of vertebral column relationship: BFO:0000050 UBERON:0006074 ! part of lumbar region of vertebral column [Term] id: UBERON:0007257 name: intervertebral disk of sacral vertebra def: "An intervertebral disk that is part of a sacral region of vertebral column. A sacral intervertebral disk connects at least one sacral vertebra, either to another thoracic vertebra, or at one point on the vertebral colummn, to a sacral vertebra." [http://orcid.org/0000-0002-6601-2165] synonym: "intervertebral disc of sacral region" EXACT [EMAPA:19575] xref: EMAPA:19575 xref: FMA:268676 is_a: UBERON:0001066 ! intervertebral disk is_a: UBERON:0005174 ! dorsal region element is_a: UBERON:0005179 ! pelvic region element is_a: UBERON:2001457 ! postcranial axial cartilage intersection_of: UBERON:0001066 ! intervertebral disk intersection_of: BFO:0000050 UBERON:0006075 ! part of sacral region of vertebral column relationship: BFO:0000050 UBERON:0006075 ! part of sacral region of vertebral column [Term] id: UBERON:0007266 name: intervertebral disk of atlas def: "An intervertebral disk that connects a vertebral bone 1 and connects a vertebral bone 2." [OBOL:automatic] synonym: "C1 disk" EXACT [] synonym: "C1 intervertebral disk" EXACT [] synonym: "first cervical intervertebral disk" EXACT [] synonym: "intervertebral disc of cervical vertebra 1" EXACT [] synonym: "intervertebral disc of first cervical vertebra" EXACT [] synonym: "intervertebral disk of cervical vertebra 1" EXACT [] synonym: "intervertebral disk of first cervical vertebra" EXACT [] synonym: "intervertebral disk, C1-C2" EXACT [] xref: EMAPA:19416 is_a: UBERON:0007252 ! intervertebral disk of cervical vertebra intersection_of: UBERON:0001066 ! intervertebral disk intersection_of: RO:0002176 UBERON:0001092 ! connects vertebral bone 1 intersection_of: RO:0002176 UBERON:0001093 ! connects vertebral bone 2 relationship: RO:0002176 UBERON:0001092 ! connects vertebral bone 1 relationship: RO:0002176 UBERON:0001093 ! connects vertebral bone 2 [Term] id: UBERON:0007267 name: trachea pre-cartilage rings def: "A pre-cartilage condensation that is part of a trachea." [OBOL:automatic] xref: EHDAA2:0002070 xref: EHDAA:7082 is_a: UBERON:0005866 ! pre-cartilage condensation is_a: UBERON:0009505 ! mesenchyme of trachea intersection_of: UBERON:0005866 ! pre-cartilage condensation intersection_of: BFO:0000050 UBERON:0003126 ! part of trachea relationship: RO:0002202 UBERON:0009505 {source="EHDAA2"} ! develops from mesenchyme of trachea property_value: skos:prefLabel "trachea pre-cartilage rings" xsd:string [Term] id: UBERON:0007269 name: pectoral appendage musculature def: "Any collection of muscles that is part of a pectoral appendage." [OBOL:automatic] subset: efo_slim synonym: "pectoral fin muscle" NARROW [ZFA:0000563] synonym: "pectoral fin musculature" NARROW SENSU [ZFA:0000563] xref: EFO:0003540 xref: TAO:0000563 xref: ZFA:0000563 is_a: UBERON:0007271 ! appendage musculature is_a: UBERON:0014793 ! musculature of pectoral complex intersection_of: UBERON:0001015 ! musculature intersection_of: BFO:0000050 UBERON:0004710 ! part of pectoral appendage relationship: BFO:0000050 UBERON:0004710 ! part of pectoral appendage property_value: IAO:0000116 "currently defined by location rather than attachment" xsd:string property_value: skos:prefLabel "pectoral appendage musculature" xsd:string [Term] id: UBERON:0007270 name: pelvic appendage musculature def: "Any collection of muscles that is part of a pelvic appendage." [OBOL:automatic] synonym: "pelvic fin musculature" NARROW SENSU [ZFA:0000258] xref: TAO:0000258 xref: ZFA:0000258 is_a: UBERON:0007271 ! appendage musculature is_a: UBERON:0014792 ! musculature of pelvic complex intersection_of: UBERON:0001015 ! musculature intersection_of: BFO:0000050 UBERON:0004709 ! part of pelvic appendage relationship: BFO:0000050 UBERON:0004709 ! part of pelvic appendage property_value: IAO:0000116 "currently defined by location rather than attachment" xsd:string [Term] id: UBERON:0007271 name: appendage musculature def: "Any collection of muscles that is part of an appendage." [OBOL:automatic] synonym: "fin musculature" NARROW SENSU [ZFA:0000207] xref: TAO:0000207 xref: ZFA:0000207 is_a: UBERON:0001015 ! musculature intersection_of: UBERON:0001015 ! musculature intersection_of: BFO:0000050 UBERON:0000026 ! part of appendage relationship: BFO:0000050 UBERON:0000026 ! part of appendage property_value: IAO:0000116 "currently defined by location rather than attachment" xsd:string property_value: skos:prefLabel "appendage musculature" xsd:string [Term] id: UBERON:0007272 name: pectoral appendage skeleton def: "Skeletal subdivision consisting of the anterior appendicular limb skeleton, excluding the pectoral girdle." [VSAO:0005000, VSAO:NI] synonym: "cheiropterygium" RELATED [VSAO:0005000, VSAO:NI] xref: VSAO:0005000 is_a: UBERON:0011582 ! paired limb/fin skeleton intersection_of: UBERON:0010912 ! subdivision of skeleton intersection_of: RO:0002576 UBERON:0004710 ! skeleton of pectoral appendage relationship: RO:0002576 UBERON:0004710 ! skeleton of pectoral appendage property_value: skos:prefLabel "pectoral appendage skeleton" xsd:string [Term] id: UBERON:0007273 name: pelvic appendage skeleton def: "The collection of all skeletal elements in a pelvic appendage region." [https://orcid.org/0000-0002-6601-2165] is_a: UBERON:0011582 ! paired limb/fin skeleton intersection_of: UBERON:0010912 ! subdivision of skeleton intersection_of: RO:0002576 UBERON:0004709 ! skeleton of pelvic appendage relationship: RO:0002576 UBERON:0004709 ! skeleton of pelvic appendage [Term] id: UBERON:0007277 name: presumptive hindbrain def: "The rhombencephalon (or hindbrain) is a developmental categorization of portions of the central nervous system in vertebrates. The rhombencephalon can be subdivided in a variable number of transversal swellings called rhombomeres. In the human embryo eight rhombomeres can be distinguished, from caudal to rostral: Rh7-Rh1 and the isthmus (the most rostral rhombomere). A rare disease of the rhombencephalon, 'rhombencephalosynapsis' is characterized by a missing vermis resulting in a fused cerebellum. Patients generally present with cerebellar ataxia. The caudal rhombencephalon has been generally considered as the initiation site for neural tube closure." [Wikipedia:Rhombencephalon] subset: efo_slim synonym: "embryonic rhombencephalon" RELATED [CALOHA:TS-2118] synonym: "future hindbrain" RELATED [https://orcid.org/0000-0002-6601-2165] synonym: "presumptive rhombencephalon" EXACT [ZFA:0000569] synonym: "rhombencephalon" RELATED [EHDAA2:0001630] xref: BAMS:HB xref: CALOHA:TS-2118 xref: EFO:0003440 xref: EHDAA2:0001630 xref: FMA:295640 xref: TAO:0000569 xref: Wikipedia:Rhombencephalon xref: ZFA:0000569 is_a: BFO:0000002 is_a: UBERON:0006598 ! presumptive structure intersection_of: UBERON:0006598 ! presumptive structure intersection_of: RO:0002387 UBERON:0002028 ! has potential to develop into hindbrain relationship: BFO:0000050 UBERON:0006238 ! part of future brain relationship: RO:0002202 UBERON:0003076 {source="XAO-abduced"} ! develops from posterior neural tube relationship: RO:0002254 UBERON:0003852 {source="cjm"} ! has developmental contribution from rhombencephalon neural crest relationship: RO:0002387 UBERON:0002028 ! has potential to develop into hindbrain property_value: IAO:0000116 "TODO - unify naming conventions" xsd:string property_value: skos:prefLabel "presumptive hindbrain" xsd:string [Term] id: UBERON:0007278 name: presumptive sinus venosus def: "Portion of tissue that is part of the heart tube and will become the sinus venosus." [ZFA:0001722] xref: TAO:0002234 xref: ZFA:0001722 is_a: UBERON:0006598 ! presumptive structure intersection_of: UBERON:0006598 ! presumptive structure intersection_of: RO:0002387 UBERON:0002063 ! has potential to develop into sinus venosus relationship: BFO:0000050 UBERON:0004141 {source="ZFA"} ! part of heart tube relationship: RO:0002387 UBERON:0002063 ! has potential to develop into sinus venosus property_value: skos:prefLabel "presumptive sinus venosus" xsd:string [Term] id: UBERON:0007280 name: presumptive endocardium def: "A presumptive structure that has the potential to develop into a endocardium." [OBOL:automatic] xref: TAO:0002233 xref: ZFA:0001724 is_a: BFO:0000002 is_a: UBERON:0006598 ! presumptive structure intersection_of: UBERON:0006598 ! presumptive structure intersection_of: RO:0002387 UBERON:0002165 ! has potential to develop into endocardium relationship: BFO:0000050 UBERON:0005498 ! part of primitive heart tube relationship: RO:0002202 UBERON:0003084 ! develops from heart primordium relationship: RO:0002387 UBERON:0002165 ! has potential to develop into endocardium property_value: skos:prefLabel "presumptive endocardium" xsd:string [Term] id: UBERON:0007281 name: presumptive midbrain hindbrain boundary def: "Embryonic structure that gives rise to the midbrain hindbrain boundary." [ZFA:0001187] subset: efo_slim synonym: "presumptive MHB" EXACT [https://orcid.org/0000-0002-6601-2165] synonym: "presumptive midbrain-hindbrain boundary" EXACT [ZFA:0001187] xref: EFO:0003446 xref: TAO:0001187 xref: XAO:0004086 xref: ZFA:0001187 is_a: UBERON:0006598 ! presumptive structure intersection_of: UBERON:0006598 ! presumptive structure intersection_of: RO:0002387 UBERON:0003052 ! has potential to develop into midbrain-hindbrain boundary relationship: BFO:0000050 UBERON:0006238 {source="ZFA"} ! part of future brain relationship: RO:0002387 UBERON:0003052 ! has potential to develop into midbrain-hindbrain boundary property_value: skos:prefLabel "presumptive midbrain hindbrain boundary" xsd:string [Term] id: UBERON:0007282 name: presumptive segmental plate def: "A presumptive structure that has the potential to develop into a presomitic mesoderm." [OBOL:automatic] subset: efo_slim synonym: "presumptive segmental plates" RELATED OMO:0003004 [ZFA:0000053] xref: EFO:0003421 xref: TAO:0000053 xref: ZFA:0000053 is_a: BFO:0000002 is_a: UBERON:0006598 ! presumptive structure intersection_of: UBERON:0006598 ! presumptive structure intersection_of: RO:0002387 UBERON:0003059 ! has potential to develop into presomitic mesoderm relationship: RO:0002202 UBERON:0009618 ! develops from trunk paraxial mesoderm relationship: RO:0002387 UBERON:0003059 ! has potential to develop into presomitic mesoderm property_value: skos:prefLabel "presumptive segmental plate" xsd:string [Term] id: UBERON:0007284 name: presumptive neural plate def: "A presumptive structure that has the potential to develop into a neural plate." [OBOL:automatic] subset: efo_slim synonym: "prospective neuroectoderm" EXACT [ZFA:0000063] synonym: "prospective vegetal ectoderm" EXACT [ZFA:0000063] xref: EFO:0003424 xref: TAO:0000063 xref: ZFA:0000063 is_a: UBERON:0016879 ! future central nervous system intersection_of: UBERON:0006598 ! presumptive structure intersection_of: RO:0002387 UBERON:0003075 ! has potential to develop into neural plate relationship: BFO:0000050 UBERON:0004734 ! part of gastrula relationship: RO:0002202 UBERON:0002346 ! develops from neurectoderm relationship: RO:0002387 UBERON:0003075 ! has potential to develop into neural plate property_value: IAO:0000116 "consider merging" xsd:string property_value: skos:prefLabel "presumptive neural plate" xsd:string [Term] id: UBERON:0007285 name: presumptive paraxial mesoderm def: "The part of the blastula that has the potential to develop into a paraxial mesoderm." [https://github.com/obophenotype/uberon/issues/1277, UBERON:cjm] subset: efo_slim synonym: "future paraxial mesenchyme" EXACT [UBERON:cjm] synonym: "future paraxial mesoderm" EXACT [] xref: EFO:0003443 xref: TAO:0000591 xref: XAO:0004134 xref: ZFA:0000591 is_a: UBERON:0006598 ! presumptive structure intersection_of: UBERON:0006598 {source="https://github.com/obophenotype/uberon/issues/1277"} ! presumptive structure intersection_of: BFO:0000050 UBERON:0000307 {source="https://github.com/obophenotype/uberon/issues/1277"} ! part of blastula intersection_of: RO:0002387 UBERON:0003077 {source="https://github.com/obophenotype/uberon/issues/1277"} ! has potential to develop into paraxial mesoderm relationship: BFO:0000050 UBERON:0000307 ! part of blastula relationship: RO:0002387 UBERON:0003077 ! has potential to develop into paraxial mesoderm property_value: skos:prefLabel "presumptive paraxial mesoderm" xsd:string [Term] id: UBERON:0007286 name: presumptive floor plate def: "A presumptive structure that has the potential to develop into a floor plate." [OBOL:automatic] subset: efo_slim xref: EFO:0003454 xref: TAO:0001218 xref: ZFA:0001218 is_a: UBERON:0006598 ! presumptive structure intersection_of: UBERON:0006598 ! presumptive structure intersection_of: RO:0002387 UBERON:0003079 ! has potential to develop into floor plate relationship: RO:0002387 UBERON:0003079 ! has potential to develop into floor plate property_value: skos:prefLabel "presumptive floor plate" xsd:string [Term] id: UBERON:0007288 name: presumptive forebrain midbrain boundary def: "A presumptive structure that has the potential to develop into a forebrain-midbrain boundary." [OBOL:automatic] subset: efo_slim xref: EFO:0003463 xref: TAO:0001368 xref: ZFA:0001368 is_a: UBERON:0006598 ! presumptive structure intersection_of: UBERON:0006598 ! presumptive structure intersection_of: RO:0002387 UBERON:0005075 ! has potential to develop into forebrain-midbrain boundary relationship: BFO:0000050 UBERON:0006238 ! part of future brain relationship: RO:0002387 UBERON:0005075 ! has potential to develop into forebrain-midbrain boundary property_value: skos:prefLabel "presumptive forebrain midbrain boundary" xsd:string [Term] id: UBERON:0007289 name: presumptive rhombomere 1 def: "A presumptive structure that has the potential to develop into a rhombomere 1." [OBOL:automatic] xref: TAO:0001207 xref: ZFA:0001207 is_a: UBERON:0006598 ! presumptive structure intersection_of: UBERON:0006598 ! presumptive structure intersection_of: RO:0002387 UBERON:0005499 ! has potential to develop into rhombomere 1 relationship: RO:0002387 UBERON:0005499 ! has potential to develop into rhombomere 1 property_value: skos:prefLabel "presumptive rhombomere 1" xsd:string [Term] id: UBERON:0007297 name: presumptive pronephric mesoderm def: "A presumptive structure that has the potential to develop into a pronephric mesoderm." [OBOL:automatic] subset: efo_slim synonym: "nephron primordium" EXACT [ZFA:0001070] xref: EFO:0003619 xref: TAO:0001070 xref: ZFA:0001070 is_a: UBERON:0006598 ! presumptive structure intersection_of: UBERON:0006598 ! presumptive structure intersection_of: RO:0002387 UBERON:0005721 ! has potential to develop into pronephric mesoderm relationship: RO:0002387 UBERON:0005721 ! has potential to develop into pronephric mesoderm [Term] id: UBERON:0007298 name: pronephric proximal convoluted tubule def: "A proximal convoluted tubule that is part of a pronephros." [OBOL:automatic] xref: TAO:0002238 xref: ZFA:0001620 is_a: UBERON:0001287 ! proximal convoluted tubule is_a: UBERON:0005310 ! pronephric nephron tubule intersection_of: UBERON:0001287 ! proximal convoluted tubule intersection_of: BFO:0000050 UBERON:0002120 ! part of pronephros [Term] id: UBERON:0007300 name: pectoral appendage blood vessel def: "A blood vessel that is part of a pectoral appendage." [OBOL:automatic] synonym: "pectoral fin blood vessel" NARROW SENSU [ZFA:0005301] xref: TAO:0005301 xref: ZFA:0005301 is_a: UBERON:0007301 ! appendage blood vessel intersection_of: UBERON:0001981 ! blood vessel intersection_of: BFO:0000050 UBERON:0004710 ! part of pectoral appendage relationship: BFO:0000050 UBERON:0004710 ! part of pectoral appendage property_value: skos:prefLabel "pectoral appendage blood vessel" xsd:string [Term] id: UBERON:0007301 name: appendage blood vessel def: "A blood vessel that is part of a limb/fin." [OBOL:automatic] synonym: "fin blood vessel" NARROW SENSU [ZFA:0005299] synonym: "limb blood vessel" NARROW SENSU [] xref: TAO:0005299 xref: ZFA:0005299 is_a: UBERON:0001981 ! blood vessel intersection_of: UBERON:0001981 ! blood vessel intersection_of: BFO:0000050 UBERON:0000026 ! part of appendage relationship: BFO:0000050 UBERON:0007304 ! part of appendage vasculature property_value: skos:prefLabel "appendage blood vessel" xsd:string [Term] id: UBERON:0007302 name: pectoral appendage vasculature def: "A vasculature that is part of a pectoral appendage." [OBOL:automatic] synonym: "pectoral fin vasculature" NARROW SENSU [ZFA:0005096] xref: TAO:0005096 xref: ZFA:0005096 is_a: UBERON:0007304 ! appendage vasculature intersection_of: UBERON:0002049 ! vasculature intersection_of: BFO:0000050 UBERON:0004710 ! part of pectoral appendage relationship: BFO:0000050 UBERON:0004710 ! part of pectoral appendage property_value: skos:prefLabel "pectoral appendage vasculature" xsd:string [Term] id: UBERON:0007303 name: pharyngeal vasculature def: "A vasculature that is part of a chordate pharynx." [OBOL:automatic] synonym: "branchial vasculature" EXACT [ZFA:0005003] xref: TAO:0005003 xref: ZFA:0005003 is_a: UBERON:0006876 ! vasculature of organ intersection_of: UBERON:0002049 ! vasculature intersection_of: BFO:0000050 UBERON:0001042 ! part of chordate pharynx relationship: BFO:0000050 UBERON:0001042 ! part of chordate pharynx property_value: skos:prefLabel "pharyngeal vasculature" xsd:string [Term] id: UBERON:0007304 name: appendage vasculature def: "A vasculature that is part of a limb/fin." [OBOL:automatic] synonym: "fin vasculature" NARROW SENSU [ZFA:0005095] xref: TAO:0005095 xref: ZFA:0005095 is_a: UBERON:0002049 ! vasculature intersection_of: UBERON:0002049 ! vasculature intersection_of: BFO:0000050 UBERON:0000026 ! part of appendage relationship: BFO:0000050 UBERON:0000026 ! part of appendage property_value: skos:prefLabel "appendage vasculature" xsd:string [Term] id: UBERON:0007306 name: pronephric glomerular capillary def: "A glomerular capillary that is part of a pronephros." [OBOL:automatic] xref: TAO:0005309 xref: ZFA:0005309 is_a: UBERON:0004212 ! glomerular capillary intersection_of: UBERON:0004212 ! glomerular capillary intersection_of: BFO:0000050 UBERON:0002120 ! part of pronephros relationship: BFO:0000050 UBERON:0004739 {is_inferred="true", source="https://github.com/obophenotype/uberon/wiki/Inferring-part-of-relationships"} ! part of pronephric glomerulus relationship: BFO:0000050 UBERON:0005309 {source="https://github.com/obophenotype/uberon/wiki/Inferring-part-of-relationships"} ! part of pronephric nephron [Term] id: UBERON:0007307 name: pronephric glomerular basement membrane def: "A glomerular basement membrane that is part of a pronephros." [OBOL:automatic] synonym: "pronephric glomerular filtration membrane" EXACT [ZFA:0005313] xref: TAO:0005313 xref: ZFA:0005313 is_a: UBERON:0005777 ! glomerular basement membrane intersection_of: UBERON:0005777 ! glomerular basement membrane intersection_of: BFO:0000050 UBERON:0002120 ! part of pronephros relationship: BFO:0000050 UBERON:0004739 {is_inferred="true", source="https://github.com/obophenotype/uberon/wiki/Inferring-part-of-relationships"} ! part of pronephric glomerulus [Term] id: UBERON:0007318 name: saphenous vein def: "Either of two main superficial veins of the leg, one larger than the other, that begin at the foot." [BTO:0001808] xref: BTO:0001808 xref: CALOHA:TS-0893 xref: EMAPA:37186 {source="MA:th"} xref: MA:0002215 xref: MESH:D012501 xref: NCIT:C33511 xref: UMLS:C0036186 {source="ncithesaurus:Saphenous_Vein"} is_a: UBERON:0004261 ! lower leg blood vessel is_a: UBERON:0035550 ! superficial vein [Term] id: UBERON:0007324 name: pancreatic lobule def: "A dense accumulation of exocrine glands in the pancreas often surrounding islets of Langerhans." [ISBN:0123813611] subset: human_reference_atlas synonym: "lobulus pancreaticus" EXACT [FMA:16012] synonym: "pancreas lobe" EXACT [MA:0000721] synonym: "pancreatic lobule" EXACT [FMA:16012] xref: EMAPA:37710 {source="MA:th"} xref: FMA:16012 xref: MA:0000721 is_a: BFO:0000002 is_a: UBERON:0000064 ! organ part relationship: BFO:0000050 UBERON:0000017 ! part of exocrine pancreas relationship: BFO:0000051 UBERON:0001263 ! has part pancreatic acinus relationship: BFO:0000051 UBERON:0014719 ! has part intralobular duct property_value: IAO:0000116 "TODO - check" xsd:string property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "pancreatic lobule" xsd:string [Term] id: UBERON:0007329 name: pancreatic duct def: "A duct that collects and carries secretions of the exocrine pancreas to the intestine." [GOC:cvs, GOC:ymb, https://github.com/obophenotype/uberon/issues/1250, https://orcid.org/0000-0002-2244-7917, https://orcid.org/0000-0002-6601-2165, https://orcid.org/0000-0002-9900-7880, Wikipedia:Pancreatic_duct] subset: human_reference_atlas subset: pheno_slim subset: vertebrate_core synonym: "duct of pancreas" EXACT [OBOL:accepted] synonym: "ductus pancreaticus" RELATED OMO:0003011 [Wikipedia:Pancreatic_duct] synonym: "pancreas duct" EXACT [OBOL:accepted] xref: EHDAA:9194 xref: EMAPA:32952 xref: FMA:10419 xref: MA:0000124 xref: SCTID:181278006 xref: TAO:0001372 xref: VHOG:0000254 xref: Wikipedia:Pancreatic_duct xref: ZFA:0001372 is_a: UBERON:0003928 {source="ZFA"} ! digestive system duct is_a: UBERON:0004119 ! endoderm-derived structure intersection_of: UBERON:0000058 ! duct intersection_of: BFO:0000050 UBERON:0001264 ! part of pancreas intersection_of: RO:0002170 UBERON:0000160 ! connected to intestine relationship: BFO:0000050 UBERON:0000017 {source="MA"} ! part of exocrine pancreas relationship: RO:0002170 UBERON:0000160 ! connected to intestine relationship: RO:0002202 UBERON:0003922 ! develops from pancreatic epithelial bud relationship: RO:0002433 UBERON:0000017 ! contributes to morphology of exocrine pancreas property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/1/15/Gray1100.png" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "pancreatic duct" xsd:string [Term] id: UBERON:0007352 name: stria vascularis vasculature def: "Blood vessels supplying the stria vascularis in the cochlea of the inner ear." [MP:0004368] synonym: "stria vascularis blood vessel" RELATED [MP:0004368] synonym: "stria vascularis blood vessels" EXACT [] is_a: UBERON:0002200 ! vasculature of head is_a: UBERON:0006876 ! vasculature of organ intersection_of: UBERON:0002049 ! vasculature intersection_of: BFO:0000050 UBERON:0002282 ! part of stria vascularis of cochlear duct relationship: BFO:0000050 UBERON:0002282 ! part of stria vascularis of cochlear duct [Term] id: UBERON:0007354 name: cartilage of pharyngotympanic tube def: "A triangular plate of elastic fibrocartilage that forms the cartilage component of the pharyngotympanic tube." [http://orcid.org/0000-0002-6601-2165, Wikipedia:Cartilage_of_pharyngotympanic_tube] synonym: "cartilage of auditory tube" EXACT [FMA:60096] synonym: "cartilage of eustachian tube" EXACT [FMA:60096] synonym: "cartilago tubae auditivae" EXACT OMO:0003011 [FMA:60096, FMA:TA] synonym: "cartilago tubae auditivae; cartilago tubae auditoriae" RELATED OMO:0003011 [Wikipedia:Cartilage_of_pharyngotympanic_tube] synonym: "cartilago tubae auditoriae" EXACT OMO:0003011 [FMA:60096, FMA:TA] synonym: "pharyngotympanic tube cartilage" EXACT [FMA:60096] xref: FMA:60096 xref: SCTID:362565000 xref: Wikipedia:Cartilage_of_pharyngotympanic_tube is_a: UBERON:0007844 ! cartilage element intersection_of: UBERON:0007844 ! cartilage element intersection_of: BFO:0000050 UBERON:0002393 ! part of pharyngotympanic tube relationship: BFO:0000050 UBERON:0002393 ! part of pharyngotympanic tube property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/b/b9/Gray915.png" xsd:anyURI [Term] id: UBERON:0007355 name: bony part of pharyngotympanic tube def: "The bony part of pharyngotympanic tube is about 12 mm. in length. It begins in the carotid wall of the tympanic cavity, below the septum canalis musculotubarii, and, gradually narrowing, ends at the angle of junction of the squama and the petrous portion of the temporal bone, its extremity presenting a jagged margin which serves for the attachment of the cartilaginous portion." [Wikipedia:Bony_part_of_pharyngotympanic_tube] synonym: "bony part of auditory tube" EXACT [FMA:60057] synonym: "bony part of eustachian tube" EXACT [FMA:60057] synonym: "osseous portion" RELATED [Wikipedia:Bony_part_of_pharyngotympanic_tube] synonym: "osseous portion of eustachian tube" EXACT [FMA:60057] synonym: "pars ossea (tuba auditiva)" EXACT [FMA:60057] synonym: "pars ossea (tuba auditoria)" EXACT [FMA:60057] synonym: "pars ossea tubae auditivae" RELATED OMO:0003011 [Wikipedia:Bony_part_of_pharyngotympanic_tube] xref: FMA:60057 xref: SCTID:362563007 xref: Wikipedia:Bony_part_of_pharyngotympanic_tube is_a: UBERON:0002481 ! bone tissue is_a: UBERON:0003566 ! head connective tissue intersection_of: UBERON:0002481 ! bone tissue intersection_of: BFO:0000050 UBERON:0002393 ! part of pharyngotympanic tube relationship: BFO:0000050 UBERON:0002393 ! part of pharyngotympanic tube property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/9/9d/Gray911.png" xsd:anyURI [Term] id: UBERON:0007367 name: surface of tongue def: "An anatomical surface that is part of a tongue." [OBOL:automatic] subset: human_reference_atlas synonym: "tongue surface" EXACT [FMA:54647] xref: FMA:54647 xref: SCTID:314870004 is_a: UBERON:0036215 ! anatomical surface region intersection_of: UBERON:0036215 ! anatomical surface region intersection_of: RO:0002007 UBERON:0001723 ! bounding layer of tongue relationship: RO:0002007 UBERON:0001723 ! bounding layer of tongue property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "surface of tongue" xsd:string [Term] id: UBERON:0007371 name: superior surface of tongue def: "The upper (superior) side of the tongue." [http://orcid.org/0000-0002-6601-2165] synonym: "dorsal surface of tongue" EXACT [FMA:54646] xref: FMA:54646 is_a: UBERON:0007367 ! surface of tongue intersection_of: UBERON:0007367 ! surface of tongue intersection_of: BSPO:0015101 UBERON:0001723 ! tongue relationship: BSPO:0015101 UBERON:0001723 ! tongue property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/mouth-female/v1.0/assets/3d-vh-f-mouth.glb" xsd:anyURI property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/mouth-male/v1.0/assets/3d-vh-m-mouth.glb" xsd:anyURI property_value: IAO:0000116 "check superior/dorsal" xsd:string property_value: skos:prefLabel "superior surface of tongue" xsd:string [Term] id: UBERON:0007373 name: inferior surface of tongue def: "The lower (inferior) side of the tongue." [http://orcid.org/0000-0002-6601-2165] synonym: "ventral surface of tongue" EXACT [FMA:54648] synonym: "ventrum linguae" EXACT [] xref: FMA:54648 xref: SCTID:362100003 is_a: UBERON:0007367 ! surface of tongue intersection_of: UBERON:0007367 ! surface of tongue intersection_of: BSPO:0015102 UBERON:0001723 ! tongue relationship: BSPO:0015102 UBERON:0001723 ! tongue property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/mouth-female/v1.0/assets/3d-vh-f-mouth.glb" xsd:anyURI property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/mouth-male/v1.0/assets/3d-vh-m-mouth.glb" xsd:anyURI property_value: IAO:0000116 "check inferior/ventral" xsd:string property_value: skos:prefLabel "inferior surface of tongue" xsd:string [Term] id: UBERON:0007375 name: roof of mouth def: "A multi-tissue structure consisting of bone and soft tissue that forms a part of the roof of the oral cavity. In mammals this is the combination of the primary palate (premaxilla) and the secondary palate. In early tetrapods it consists of the vomer, pterygoid, parasphenoid, palatine and ectopterygoid bones." [https://orcid.org/0000-0002-6601-2165] subset: grouping_class synonym: "palate" RELATED [] synonym: "palatum" RELATED INCONSISTENT [] synonym: "primary or secondary palate" RELATED [] synonym: "roof of buccal cavity" EXACT [] synonym: "roof of oral cavity" EXACT [] xref: CALOHA:TS-2212 xref: Wikipedia:Palate is_a: UBERON:0000481 ! multi-tissue structure relationship: BFO:0000050 UBERON:0000033 ! part of head property_value: IAO:0000116 "check subclasses to verify if they refer to a multi-tissue structure or a subdivision of the skeleton" xsd:string property_value: skos:prefLabel "roof of mouth" xsd:string [Term] id: UBERON:0007376 name: outer epithelium def: "The epidermis is the entire outer epithelial layer of an animal, it may be a single layer that produces an extracellular material (e.g. the cuticle of arthropods) or a complex stratified squamous epithelium, as in the case of many vertebrate species[GO]." [GO:0008544] subset: grouping_class synonym: "epidermis" EXACT [GO:0008544] synonym: "epidermis (sensu Metazoa)" EXACT [] synonym: "hypoderm" RELATED INCONSISTENT [BTO:0000313] synonym: "hypodermis" RELATED INCONSISTENT [GO:0008544, WBbt:0005733] synonym: "outer epidermal layer" EXACT [] synonym: "outer epithelial layer" EXACT [] xref: BSA:0000073 xref: BTO:0000313 xref: FBbt:00004993 {sssom:mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"} xref: HAO:0000298 xref: TADS:0000109 xref: WBbt:0005733 xref: Wikipedia:Epidermis_(zoology) is_a: BFO:0000002 is_a: UBERON:0000483 ! epithelium is_a: UBERON:0003102 ! surface structure intersection_of: UBERON:0000483 ! epithelium intersection_of: RO:0002007 UBERON:0000468 ! bounding layer of multicellular organism intersection_of: RO:0002202 UBERON:0007383 ! develops from enveloping layer of ectoderm relationship: RO:0002007 UBERON:0000468 ! bounding layer of multicellular organism relationship: RO:0002202 UBERON:0007383 ! develops from enveloping layer of ectoderm property_value: IAO:0000116 "this grouping class exists primarily to align with GO - see GO:0008544." xsd:string property_value: skos:prefLabel "outer epithelium" xsd:string [Term] id: UBERON:0007383 name: enveloping layer of ectoderm def: "Outermost layer of cells surrounding the embryo." [http://orcid.org/0000-0002-6601-2165] subset: efo_slim synonym: "enveloping layer" EXACT [ZFIN:ZDB-PUB-961014-576] synonym: "EVL" EXACT [ZFA:0000086] xref: EFO:0003425 xref: TAO:0000086 xref: ZFA:0000086 is_a: BFO:0000002 is_a: UBERON:0000490 ! unilaminar epithelium is_a: UBERON:0005291 ! embryonic tissue relationship: RO:0002007 UBERON:0000922 ! bounding layer of embryo relationship: RO:0002202 UBERON:0000076 ! develops from external ectoderm property_value: skos:prefLabel "enveloping layer of ectoderm" xsd:string [Term] id: UBERON:0007384 name: appendage lymph vessel def: "A lymphatic vessel that is part of a limb/fin." [OBOL:automatic] xref: TAO:0005300 xref: ZFA:0005300 is_a: UBERON:0001473 ! lymphatic vessel intersection_of: UBERON:0001473 ! lymphatic vessel intersection_of: BFO:0000050 UBERON:0004708 ! part of paired limb/fin relationship: BFO:0000050 UBERON:0004708 ! part of paired limb/fin relationship: BFO:0000050 UBERON:0007304 ! part of appendage vasculature [Term] id: UBERON:0007385 name: pectoral appendage lymph vessel def: "A lymphatic vessel that is part of a pectoral appendage." [OBOL:automatic] xref: TAO:0005302 xref: ZFA:0005302 is_a: UBERON:0007384 ! appendage lymph vessel intersection_of: UBERON:0001473 ! lymphatic vessel intersection_of: BFO:0000050 UBERON:0004710 ! part of pectoral appendage relationship: BFO:0000050 UBERON:0007302 ! part of pectoral appendage vasculature [Term] id: UBERON:0007386 name: pelvic appendage lymph vessel def: "A lymphatic vessel that is part of a pelvic appendage." [OBOL:automatic] is_a: UBERON:0007384 ! appendage lymph vessel intersection_of: UBERON:0001473 ! lymphatic vessel intersection_of: BFO:0000050 UBERON:0004709 ! part of pelvic appendage relationship: BFO:0000050 UBERON:0004709 ! part of pelvic appendage [Term] id: UBERON:0007389 name: paired limb/fin cartilage def: "A cartilage tissue that is part of a paired limb or fin." [http://orcid.org/0000-0002-6601-2165] subset: homology_grouping xref: TAO:0001543 xref: ZFA:0001543 is_a: UBERON:0002418 ! cartilage tissue intersection_of: UBERON:0002418 ! cartilage tissue intersection_of: BFO:0000050 UBERON:0004708 ! part of paired limb/fin relationship: BFO:0000050 UBERON:0002091 ! part of appendicular skeleton relationship: BFO:0000050 UBERON:0004708 ! part of paired limb/fin property_value: skos:prefLabel "paired limb/fin cartilage" xsd:string [Term] id: UBERON:0007390 name: pectoral appendage cartilage tissue def: "A cartilage tissue that is part of a pectoral appendage." [OBOL:automatic] synonym: "pectoral fin cartilage" RELATED [TAO:0000257] xref: TAO:0000257 xref: ZFA:0000257 is_a: UBERON:0007389 ! paired limb/fin cartilage intersection_of: UBERON:0002418 ! cartilage tissue intersection_of: BFO:0000050 UBERON:0004710 ! part of pectoral appendage relationship: BFO:0000050 UBERON:0007272 ! part of pectoral appendage skeleton property_value: skos:prefLabel "pectoral appendage cartilage tissue" xsd:string [Term] id: UBERON:0007391 name: pelvic appendage cartilage tissue def: "A cartilage tissue that is part of a pelvic appendage." [OBOL:automatic] synonym: "pelvic fin cartilage" RELATED [TAO:0001459] xref: TAO:0001459 xref: ZFA:0001459 is_a: UBERON:0007389 ! paired limb/fin cartilage intersection_of: UBERON:0002418 ! cartilage tissue intersection_of: BFO:0000050 UBERON:0004709 ! part of pelvic appendage relationship: BFO:0000050 UBERON:0007273 ! part of pelvic appendage skeleton [Term] id: UBERON:0007414 name: nucleus of midbrain tegmentum def: "A nucleus of brain that spans a midbrain tegmentum." [OBOL:automatic] synonym: "tegmental nuclei" EXACT OMO:0003004 [] synonym: "tegmental nucleus" EXACT [ZFA:0005577] xref: FMA:258768 xref: ZFA:0005577 is_a: UBERON:0000125 ! neural nucleus intersection_of: UBERON:0000125 ! neural nucleus intersection_of: RO:0002131 UBERON:0001943 ! overlaps midbrain tegmentum relationship: RO:0002131 UBERON:0001943 ! overlaps midbrain tegmentum property_value: skos:prefLabel "nucleus of midbrain tegmentum" xsd:string [Term] id: UBERON:0007415 name: nucleus of midbrain reticular formation def: "A nucleus of midbrain tegmentum that is part of a midbrain reticular formation." [OBOL:automatic] synonym: "mesencephalic reticular nucleus" RELATED [BAMS:MRN] synonym: "midbrain reticular formation nucleus" EXACT [FMA:62443] synonym: "midbrain reticular nucleus" EXACT [ABA:MRN] xref: BAMS:MRN xref: FMA:62443 xref: MBA:128 xref: neuronames:1993 is_a: UBERON:0006331 ! brainstem nucleus is_a: UBERON:0007414 ! nucleus of midbrain tegmentum is_a: UBERON:0009661 ! midbrain nucleus intersection_of: UBERON:0000125 ! neural nucleus intersection_of: BFO:0000050 UBERON:0002639 ! part of midbrain reticular formation relationship: BFO:0000050 UBERON:0002639 ! part of midbrain reticular formation property_value: skos:prefLabel "nucleus of midbrain reticular formation" xsd:string [Term] id: UBERON:0007416 name: cerebellar peduncle def: "Any of the three large paired bundles of nerve fibers that connect the cerebellum to the brain stem." [MGI:csmith, MP:0009976] subset: pheno_slim synonym: "cerebellum peduncle" RELATED [EMAPA:35213] xref: BAMS:cbp xref: EMAPA:35213 xref: FMA:272298 xref: MA:0002742 xref: MBA:752 xref: NCIT:C88147 xref: neuronames:1207 xref: SCTID:362417003 xref: UMLS:C0228515 {source="ncithesaurus:Cerebellar_Peduncle"} is_a: UBERON:0007417 {source="FMA"} ! peduncle of neuraxis is_a: UBERON:0014891 ! brainstem white matter relationship: BFO:0000050 UBERON:0002474 ! part of cerebellar peduncular complex relationship: RO:0002433 UBERON:0002317 ! contributes to morphology of white matter of cerebellum property_value: skos:prefLabel "cerebellar peduncle" xsd:string [Term] id: UBERON:0007417 name: peduncle of neuraxis synonym: "neuraxis peduncle" EXACT [FMA:83860] xref: FMA:83860 is_a: UBERON:0002316 ! white matter property_value: skos:prefLabel "peduncle of neuraxis" xsd:string [Term] id: UBERON:0007418 name: neural decussation def: "Nerve fibers crossing the midline of the neuraxis relative to their point of origin, on a course to from one level of the nervous system to another. (CUMBO, Heimer, L. The Human Brain, 2nd ed., 1995, pg 6)." [NLX:144064] subset: cumbo synonym: "chiasm" BROAD [] synonym: "chiasma" BROAD [] synonym: "decussation" BROAD [] synonym: "decussation of neuraxis" EXACT [FMA:83858] synonym: "neuraxis chiasm" EXACT [] synonym: "neuraxis chiasma" EXACT [] synonym: "neuraxis decussation" EXACT [FMA:83858] xref: FMA:83858 xref: NCIT:C28351 xref: NLX:144064 is_a: UBERON:0000122 ! neuron projection bundle is_a: UBERON:0011215 ! central nervous system cell part cluster relationship: BFO:0000050 UBERON:0002316 ! part of white matter property_value: skos:prefLabel "neural decussation" xsd:string [Term] id: UBERON:0007425 name: decussation of diencephalon def: "A neural decussation that is part of a diencephalon." [OBOL:automatic] synonym: "diencephalon decussation" EXACT [FMA:62446] xref: FMA:62446 is_a: UBERON:0007418 {source="FMA"} ! neural decussation intersection_of: UBERON:0007418 ! neural decussation intersection_of: BFO:0000050 UBERON:0001894 ! part of diencephalon relationship: BFO:0000050 UBERON:0001894 {source="Obol"} ! part of diencephalon property_value: skos:prefLabel "decussation of diencephalon" xsd:string [Term] id: UBERON:0007473 name: lumen of epithelial sac def: "The space within an epithelial sphere." [AEO:JB] synonym: "cavity of vesicle" EXACT [AEO:0000079] xref: AEO:0000079 is_a: UBERON:0012467 ! enclosed anatomical space intersection_of: UBERON:0000464 ! anatomical space intersection_of: RO:0002572 UBERON:0007499 ! luminal space of epithelial sac relationship: RO:0002572 UBERON:0007499 ! luminal space of epithelial sac property_value: skos:prefLabel "lumen of epithelial sac" xsd:string [Term] id: UBERON:0007475 name: matrix-based tissue def: "A tissue whose predominant feature is extracellular matrix which may or may not be highly hydrated or calcified." [AEO:JB] xref: AEO:0000081 xref: EHDAA2:0003081 is_a: UBERON:0000479 ! tissue intersection_of: UBERON:0000479 ! tissue intersection_of: RO:0002473 GO:0031012 ! composed primarily of extracellular matrix relationship: RO:0002473 GO:0031012 ! composed primarily of extracellular matrix property_value: skos:prefLabel "matrix-based tissue" xsd:string [Term] id: UBERON:0007490 name: keratin-based acellular structure def: "Acellular anatomical structure whose predominant constituent is keratin." [AEO:JB] synonym: "keratin-based structure" RELATED [EHDAA2:0003099] xref: AEO:0000099 xref: EHDAA2:0003099 is_a: UBERON:0000476 ! acellular anatomical structure intersection_of: UBERON:0000476 ! acellular anatomical structure intersection_of: RO:0002473 GO:0045095 ! composed primarily of keratin filament relationship: RO:0000086 PATO:0002507 ! has quality keratinous relationship: RO:0002473 GO:0045095 ! composed primarily of keratin filament property_value: IAO:0000116 "should all structures composed primarily of keratin be classified here? At what stage of cornification are keratin-filled cells no longer considered cells" xsd:string [Term] id: UBERON:0007499 name: epithelial sac def: "An epithelial tube that is open at one end only." [AEO:JB, UBERONREF:0000001] xref: AEO:0000115 xref: EHDAA2:0003115 is_a: UBERON:0003914 {source="AEO"} ! epithelial tube is_a: UBERON:0009856 ! sac intersection_of: UBERON:0000483 ! epithelium intersection_of: RO:0000086 PATO:0001987 ! has quality saccular property_value: skos:prefLabel "epithelial sac" xsd:string [Term] id: UBERON:0007500 name: epithelial tube open at both ends def: "An epithelial tube open at both ends that allows fluid flow." [AEO:JB, UBERONREF:0000001] xref: AEO_RETIRED:0000116 xref: RETIRED_EHDAA2:0003116 is_a: UBERON:0003914 {source="AEO"} ! epithelial tube property_value: skos:prefLabel "epithelial tube open at both ends" xsd:string [Term] id: UBERON:0007501 name: arborizing epithelial duct system def: "A collection of connected epithelial tubes with a single portal." [AEO:JB, UBERONREF:0000001] synonym: "arborising epithelial duct system" EXACT [AEO:0000117] xref: AEO:0000117 xref: EHDAA2:0003117 is_a: UBERON:0007499 {source="AEO"} ! epithelial sac relationship: BFO:0000051 UBERON:0003914 {source="AEO"} ! has part epithelial tube [Term] id: UBERON:0007503 name: epithelial vesicle def: "A closed epithelium with a lumen." [AEO:JB] xref: AEO:0000119 xref: EHDAA2:0003119 is_a: UBERON:0000483 {source="AEO"} ! epithelium property_value: skos:prefLabel "epithelial vesicle" xsd:string [Term] id: UBERON:0007521 name: smooth muscle sphincter def: "A ring of smooth muscle cells whose contraction closes the opening of the ring." [AEO:JB] xref: AEO:0000143 xref: EHDAA2:0003143 xref: SCTID:362915001 is_a: UBERON:0004590 ! sphincter muscle intersection_of: UBERON:0004590 ! sphincter muscle intersection_of: BFO:0000051 CL:0000192 ! has part smooth muscle cell relationship: RO:0002473 UBERON:0001135 ! composed primarily of smooth muscle tissue property_value: skos:prefLabel "smooth muscle sphincter" xsd:string [Term] id: UBERON:0007522 name: striated muscle sphincter def: "A ring of striated muscle cells whose contraction closes the opening of the ring." [AEO:JB] xref: AEO:0000144 xref: EHDAA2:0003144 is_a: UBERON:0004590 ! sphincter muscle intersection_of: UBERON:0004590 ! sphincter muscle intersection_of: BFO:0000051 CL:0000737 ! has part striated muscle cell relationship: RO:0002473 UBERON:0002036 ! composed primarily of striated muscle tissue property_value: skos:prefLabel "striated muscle sphincter" xsd:string [Term] id: UBERON:0007524 name: dense mesenchyme tissue def: "Mesenchyme with little extracellular matrix." [AEO:JB] xref: AEO:0000146 xref: EHDAA2:0003146 is_a: BFO:0000002 is_a: UBERON:0003104 {source="AEO"} ! mesenchyme relationship: BFO:0000051 CL:0000057 {source="AEO"} ! has part fibroblast property_value: skos:prefLabel "dense mesenchyme tissue" xsd:string [Term] id: UBERON:0007529 name: loose mesenchyme tissue def: "Mesenchyme whose cells are embedded in obvious amounts of extracellular matrix." [AEO:JB] xref: AEO:0000151 xref: EHDAA2:0003151 is_a: BFO:0000002 is_a: UBERON:0003104 {source="AEO"} ! mesenchyme relationship: BFO:0000051 CL:0000057 {source="AEO"} ! has part fibroblast relationship: BFO:0000051 CL:0000327 {source="AEO"} ! has part extracellular matrix secreting cell [Term] id: UBERON:0007530 name: migrating mesenchyme population def: "Mesenchymal cells that are migrating." [AEO:JB] xref: AEO:0000152 xref: EHDAA2:0003152 is_a: BFO:0000002 is_a: UBERON:0003104 ! mesenchyme intersection_of: UBERON:0003104 ! mesenchyme intersection_of: RO:0000056 GO:0016477 ! participates in cell migration relationship: RO:0000056 GO:0016477 ! participates in cell migration property_value: IAO:0000116 "this class will be an important part of the NC reorganization" xsd:string property_value: skos:prefLabel "migrating mesenchyme population" xsd:string [Term] id: UBERON:0007567 name: regenerating anatomical structure def: "An anatomical structure that is undergoing regeneration." [http://orcid.org/0000-0002-6601-2165] synonym: "regenerating tissue" RELATED [ZFA:0005147] synonym: "regenerating tissues" RELATED OMO:0003004 [ZFA:0005147] synonym: "regenerative tissue" RELATED [] xref: AEO:0000200 xref: EHDAA2:0003233 xref: TAO:0005147 xref: XAO:0004059 xref: ZFA:0005147 is_a: BFO:0000002 is_a: UBERON:0000061 ! anatomical structure intersection_of: UBERON:0000061 ! anatomical structure intersection_of: RO:0000056 GO:0031099 ! participates in regeneration relationship: BFO:0000050 UBERON:0000468 ! part of multicellular organism relationship: RO:0000056 GO:0031099 ! participates in regeneration property_value: IAO:0000116 "we define this in terms of active participation in regeneration, rather that capabilities. In this sense it is different from the AEO structure." xsd:string [Term] id: UBERON:0007589 name: ciliated columnar oviduct epithelium def: "A ciliated columnar epithelium that is part of a oviduct." [OBOL:automatic] subset: human_reference_atlas synonym: "epithelium of uterine tube" RELATED [FMA:62016] synonym: "uterine tube epithelium" RELATED [FMA:62016] xref: FMA:62016 xref: MA:0001719 is_a: UBERON:0004804 {source="MA"} ! oviduct epithelium is_a: UBERON:0007592 {source="FMA"} ! ciliated columnar epithelium intersection_of: UBERON:0007592 ! ciliated columnar epithelium intersection_of: BFO:0000050 UBERON:0000993 ! part of oviduct property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0007590 name: cuboidal oviduct epithelium def: "A cuboidal epithelium that is part of a oviduct." [OBOL:automatic] subset: human_reference_atlas xref: MA:0001720 is_a: UBERON:0004804 {source="MA"} ! oviduct epithelium is_a: UBERON:0010077 ! cuboidal epithelium intersection_of: UBERON:0010077 ! cuboidal epithelium intersection_of: BFO:0000050 UBERON:0000993 ! part of oviduct property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0007592 name: ciliated columnar epithelium def: "Simple columnar epithelium in which the luminal side of the cells bears cilia. Examples: epithelium of trachea, epithelium of uterine tube.[FMA]." [FMA:64798] xref: FMA:64798 is_a: UBERON:0000485 {source="FMA"} ! simple columnar epithelium is_a: UBERON:0007601 ! ciliated epithelium intersection_of: UBERON:0000485 ! simple columnar epithelium intersection_of: BFO:0000051 CL:0000067 ! has part ciliated epithelial cell property_value: skos:prefLabel "ciliated columnar epithelium" xsd:string [Term] id: UBERON:0007601 name: ciliated epithelium def: "Epithelium bearing vibratile cilia on the free surface." [http://medical-dictionary.thefreedictionary.com/ciliated+epithelium] is_a: UBERON:0000483 ! epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: BFO:0000051 CL:0000067 ! has part ciliated epithelial cell relationship: BFO:0000051 CL:0000067 ! has part ciliated epithelial cell property_value: skos:prefLabel "ciliated epithelium" xsd:string [Term] id: UBERON:0007602 name: stratified columnar epithelium def: "Stratified columnar epithelia is a rare type of epithelial tissue composed of column shaped cells arranged in multiple layers. Stratified columnar epithelia are found in the ocular conjunctiva of the eye, in parts of the pharynx and anus, the female's uterus, the male urethra and vas deferens. Also found in intralobular ducts in salivary glands.[WP]." [Wikipedia:Stratified_columnar_epithelia] synonym: "epithelium stratificatum columnare" EXACT [FMA:45564] xref: FMA:45564 xref: NCIT:C33620 xref: UMLS:C0836132 {source="ncithesaurus:Stratified_Columnar_Epithelium"} xref: Wikipedia:Stratified_columnar_epithelia is_a: UBERON:0000486 {source="FMA"} ! multilaminar epithelium is_a: UBERON:0012274 ! columnar epithelium [Term] id: UBERON:0007606 name: ciliated stratified columnar epithelium xref: FMA:67521 is_a: UBERON:0007601 ! ciliated epithelium is_a: UBERON:0007602 {source="FMA"} ! stratified columnar epithelium intersection_of: UBERON:0007602 ! stratified columnar epithelium intersection_of: BFO:0000051 CL:0000067 ! has part ciliated epithelial cell [Term] id: UBERON:0007616 name: layer of synovial tissue def: "A thin, loose vascular connective tissue that makes up the membranes surrounding joints and the sheaths protecting tendons (particularly flexor tendons in the hands and feet) where they pass over bony prominences. Synovial tissue contains synovial cells, which secrete a viscous liquid called synovial fluid; this liquid contains protein and hyaluronic acid and serves as a lubricant and nutrient for the joint cartilage surfaces[BTO]. Synovial tissue can be found in tendons (tissues that connect muscle to bone), bursae (fluid-filled, cushioning sacs found in spaces between tendons, ligaments, and bones), and the cavity (hollow enclosed area) that separates the bones of a freely movable joint, such as the knee or elbow[BTO]." [BTO:0001338, http://www.britannica.com/EBchecked/topic/578563/synovial-tissue] synonym: "stratum synoviale" NARROW [FMA:TA] synonym: "synovial layer" NARROW [FMA:66762] synonym: "synovial membrane" NARROW [FMA:66762] synonym: "synovial tissue" RELATED [BTO:0001338] synonym: "synovium" EXACT [CALOHA:TS-0998] xref: BTO:0001338 xref: CALOHA:TS-0998 xref: FMA:66762 is_a: UBERON:0000042 ! serous membrane intersection_of: UBERON:0000042 ! serous membrane intersection_of: RO:0003000 UBERON:0001090 ! produces synovial fluid relationship: RO:0002473 UBERON:0002384 {source="BTO"} ! composed primarily of connective tissue relationship: RO:0003000 UBERON:0001090 ! produces synovial fluid property_value: skos:prefLabel "layer of synovial tissue" xsd:string [Term] id: UBERON:0007617 name: synovial cavity of joint def: "An anatomical cavity that surrounded_by a synovial joint." [OBOL:automatic] synonym: "articular cavity (synovial joint)" EXACT [FMA:11356] synonym: "cavitas articularis (junctura synovialis)" EXACT [FMA:11356] synonym: "cavity of synovial joint" EXACT [FMA:11356] synonym: "joint cavity" RELATED [FMA:11356] synonym: "synovial cavity" RELATED [FMA:11356] xref: FMA:11356 is_a: UBERON:0002553 ! anatomical cavity intersection_of: UBERON:0002553 ! anatomical cavity intersection_of: RO:0002572 UBERON:0002217 ! luminal space of synovial joint relationship: RO:0002572 UBERON:0002217 ! luminal space of synovial joint property_value: skos:prefLabel "synovial cavity of joint" xsd:string [Term] id: UBERON:0007619 name: limiting membrane of retina subset: grouping_class synonym: "retina lamina" EXACT [https://github.com/obophenotype/uberon/issues/52, MA:0001318] xref: MA:0001318 xref: SCTID:280667001 is_a: UBERON:0001781 {source="UBERON"} ! layer of retina relationship: BFO:0000050 UBERON:0003902 ! part of retinal neural layer [Term] id: UBERON:0007625 name: pigment epithelium of eye def: "Epithelial layer of the retina, ciliary body, or iris composed of cells containing pigment granules." [MP:0005200] subset: pheno_slim synonym: "eye pigment epithelium" RELATED [MESH:A09.371.670] xref: GAID:907 xref: MESH:D010857 is_a: UBERON:0019304 ! sensory organ epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: BFO:0000050 UBERON:0000970 ! part of eye relationship: BFO:0000050 UBERON:0000970 ! part of eye property_value: skos:prefLabel "pigment epithelium of eye" xsd:string [Term] id: UBERON:0007628 name: lateral septal complex def: "The lateral septal area; largest nuclear mass in this region, plays a pivotal role in various physiological processes, such as aggression, emotion, thermoregulation, water and food intake and sexual behaviour." [BTO:0003937, http://www.fact-archive.com/] synonym: "lateral septal area" EXACT [BTO:0003937] synonym: "lateral septum" RELATED [] synonym: "lateral septum complex" RELATED [BAMS:LSX] xref: BAMS:LSX xref: BTO:0003937 xref: EMAPA:35485 xref: MA:0000933 xref: MBA:275 xref: neuronames:2672 is_a: UBERON:0002663 {source="MA"} ! septal nuclear complex disjoint_from: UBERON:0007629 {source="lexical"} ! medial septal complex relationship: BFO:0000050 UBERON:0002435 {source="ABA"} ! part of striatum property_value: skos:prefLabel "lateral septal complex" xsd:string [Term] id: UBERON:0007629 name: medial septal complex def: "A septal nuclear complex that consists of the nucleus of the diagonal bands and the septal medial nuclei." [https://github.com/obophenotype/uberon/issues/1356] synonym: "medial septum complex" RELATED [BAMS:MSX] xref: BAMS:MSC xref: BAMS:MSX xref: EMAPA:35552 xref: MA:0000934 xref: MBA:904 xref: neuronames:1958 is_a: UBERON:0002663 {source="MA"} ! septal nuclear complex property_value: skos:prefLabel "medial septal complex" xsd:string [Term] id: UBERON:0007635 name: nucleus of medulla oblongata def: "A neural nucleus that is part of a medulla oblongata." [OBOL:automatic] xref: FMA:258772 xref: SCTID:304943004 is_a: UBERON:0006331 ! brainstem nucleus is_a: UBERON:0009662 ! hindbrain nucleus intersection_of: UBERON:0000125 ! neural nucleus intersection_of: BFO:0000050 UBERON:0001896 ! part of medulla oblongata relationship: BFO:0000050 UBERON:0001896 ! part of medulla oblongata property_value: skos:prefLabel "nucleus of medulla oblongata" xsd:string [Term] id: UBERON:0007637 name: hippocampus stratum lucidum def: "Layer of hippocampus area CA3 lying superficial to the pyramidal cell layer that contains mossy fiber axons projecting from the dentate gyrus. A slight thickening in this layer marks the border in some species between areas CA2 and CA3. dapted from Paxinos, G. The rat central nervous system, 2nd ed, Academic Press, San Diego, 1995, pg. 460)." [BIRNLEX:4108] synonym: "stratum lucidum" BROAD [BIRNLEX:4108] synonym: "stratum lucidum hippocampi" RELATED OMO:0003011 [Wikipedia:Stratum_lucidum_of_hippocampus] synonym: "stratum lucidum hippocampus" RELATED [BAMS:SLu] xref: BAMS:SLu xref: BIRNLEX:4108 xref: EMAPA:35411 xref: neuronames:1777 xref: OldNeuroNames:-975815906 {source="BIRNLEX:4108"} xref: UMLS:C0221922 {source="ncithesaurus:Stratum_Lucidum"} xref: Wikipedia:Stratum_lucidum_of_hippocampus is_a: UBERON:0002305 ! layer of hippocampus intersection_of: UBERON:0002305 ! layer of hippocampus intersection_of: BSPO:0001107 UBERON:0005372 ! hippocampus stratum radiatum intersection_of: BSPO:0015014 UBERON:0002313 ! hippocampus pyramidal layer relationship: BFO:0000051 GO:0097457 ! has part hippocampal mossy fiber relationship: BSPO:0001107 UBERON:0005372 ! hippocampus stratum radiatum relationship: BSPO:0015014 UBERON:0002313 ! hippocampus pyramidal layer property_value: skos:prefLabel "hippocampus stratum lucidum" xsd:string [Term] id: UBERON:0007639 name: hippocampus alveus def: "Regional part of fornix consisting of a thin layer of white matter on the surface of the hippocampal formation, bordering the wall of the lateral ventricle and composed of white, myelinated fibers. The alveus arises from cell bodies in the subiculum and hippocampus, and eventually merges with the fimbria of the hippocampus. The fimbria goes on to become the fornix (MM: 2006-10-26)." [BIRNLEX:1510] synonym: "alveus" EXACT [BIRNLEX:1510] synonym: "alveus hippocampi" RELATED OMO:0003011 [NeuroNames:186] synonym: "alveus of fornix" RELATED [BAMS:alv] synonym: "alveus of hippocampus" EXACT [FMA:83867] synonym: "alveus of the hippocampus" RELATED [BAMS:alv] synonym: "CA2 alveus" RELATED [BAMS:alv] synonym: "neuraxis alveus" EXACT [FMA:83867] xref: BAMS:Alv xref: BAMS:alv xref: BIRNLEX:1510 xref: DHBA:10570 xref: FMA:83867 xref: HBA:9234 xref: MBA:466 xref: NCIT:C32058 xref: neuronames:186 {source="BIRNLEX:1510"} xref: SCTID:369094002 xref: UMLS:C0228247 {source="BIRNLEX:1510", source="ncithesaurus:Alveus"} is_a: UBERON:0011215 ! central nervous system cell part cluster is_a: UBERON:0016549 ! central nervous system white matter layer relationship: BFO:0000050 UBERON:0002421 {source="NIFSTD"} ! part of hippocampal formation relationship: RO:0002150 UBERON:0002310 ! continuous with hippocampus fimbria property_value: IAO:0000116 "TODO - check xref: NCIT:C32058 ! Alveus" xsd:string property_value: skos:prefLabel "hippocampus alveus" xsd:string [Term] id: UBERON:0007641 name: trigeminal nuclear complex def: "The sensory trigeminal nerve nuclei are the largest of the cranial nerve nuclei, and extend through the whole of the midbrain, pons and medulla. There is also a distinct trigeminal motor nucleus that is medial to the chief sensory nucleus[WP]." [Wikipedia:Trigeminal_nerve_nuclei] synonym: "nuclei trigemini" RELATED OMO:0003011 [Wikipedia:Trigeminal_nerve_nuclei] synonym: "trigeminal nuclei" EXACT [FMA:71248] xref: BIRNLEX:4096 xref: BM:V xref: CALOHA:TS-2077 xref: DHBA:266441713 xref: FMA:71248 xref: HBA:9203 xref: MESH:D014278 {sssom:mapping_justification="https://w3id.org/semapv/vocab/LexicalMatching"} xref: neuronames:2021 xref: UMLS:C0040999 {source="BIRNLEX:4096"} xref: Wikipedia:Trigeminal_nerve_nuclei is_a: UBERON:0007245 {source="FMA"} ! nuclear complex of neuraxis relationship: extends_fibers_into UBERON:0001645 ! trigeminal nerve relationship: RO:0002131 UBERON:0003023 {source="FMA"} ! overlaps pontine tegmentum property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/3/30/Gray696.png" xsd:anyURI property_value: skos:prefLabel "trigeminal nuclear complex" xsd:string [Term] id: UBERON:0007644 name: thoracic lymph node def: "A lymph node that is part of a thorax. Includes lymph nodes of the lungs and mediastinal lymph nodes." [OBOL:automatic, Wikipedia:Lymph_node#Lymph_nodes_of_the_thorax] synonym: "deep thoracic lymph node" RELATED [FMA:12772] synonym: "lymph node of thorax" EXACT [FMA:12772] xref: FMA:12772 xref: NCIT:C33769 xref: SCTID:196374005 xref: UMLS:C0229745 {source="ncithesaurus:Thoracic_Lymph_Node"} xref: Wikipedia:Lymph_node#Lymph_nodes_of_the_thorax is_a: UBERON:0000029 ! lymph node is_a: UBERON:0005181 ! thoracic segment organ intersection_of: UBERON:0000029 ! lymph node intersection_of: BFO:0000050 UBERON:0000915 ! part of thoracic segment of trunk [Term] id: UBERON:0007645 name: future meninx def: "A developing mesenchymal capsule that covers the developing brain and spinal cord and is the precursor of the meningeal cluster. In mammals this gives rise to the arachnoid mater, pia mater and dura mater. In cyclostomes and fishes, the future meninx gives rise to a single meningeal layer, the primitive meninx." [http://orcid.org/0000-0002-6601-2165] subset: pheno_slim synonym: "meninx primitiva" RELATED [MP:0009726] synonym: "primary meninx" EXACT [EHDAA2:0004453] synonym: "primitive meninx" RELATED [] synonym: "primordial meninx" RELATED [] xref: EHDAA2:0004453 is_a: BFO:0000002 is_a: UBERON:0006598 ! presumptive structure intersection_of: UBERON:0006598 ! presumptive structure intersection_of: RO:0002387 UBERON:0002360 ! has potential to develop into meninx relationship: BFO:0000050 UBERON:0010743 {source="EHDAA2"} ! part of meningeal cluster relationship: RO:0002254 UBERON:0007213 {source="ISBN:0073040584"} ! has developmental contribution from mesenchyme derived from head neural crest relationship: RO:0002387 UBERON:0002360 ! has potential to develop into meninx property_value: IAO:0000116 "decide whether to treat the endo and ecto meninx as subtypes or parts of the future meninx" xsd:string property_value: skos:prefLabel "future meninx" xsd:string [Term] id: UBERON:0007646 name: endomeninx def: "The innermost layer of the mesenchymal capsule that surrounds the developing brain, primarily of neural crest origin. The endomeninx forms the leptomeninx." [ISBN:9781607950325] synonym: "future leptomeninges" EXACT [] synonym: "future leptomeninx" EXACT [] is_a: UBERON:0007645 ! future meninx intersection_of: UBERON:0007645 ! future meninx intersection_of: RO:0002387 UBERON:0000391 ! has potential to develop into leptomeninx relationship: RO:0002202 UBERON:0007213 {source="ISBN:9781607950325"} ! develops from mesenchyme derived from head neural crest relationship: RO:0002387 UBERON:0000391 ! has potential to develop into leptomeninx property_value: skos:prefLabel "endomeninx" xsd:string [Term] id: UBERON:0007647 name: ectomeninx def: "The outermost layer of the mesenchymal capsule that surrounds the developing brain, of mixed paraxial mesoderm and neural crest origin. The ectomeninx forms the dura mater (both inner layer and outer chondrogenic layer)." [ISBN:9781607950325] synonym: "future dura mater" EXACT [EHDAA2:0004317] xref: EHDAA2:0004317 is_a: UBERON:0007645 ! future meninx intersection_of: UBERON:0007645 ! future meninx intersection_of: RO:0002387 UBERON:0002363 ! has potential to develop into dura mater relationship: RO:0002202 UBERON:0009617 {source="ISBN:9781607950325"} ! develops from head paraxial mesoderm relationship: RO:0002387 UBERON:0002363 ! has potential to develop into dura mater property_value: skos:prefLabel "ectomeninx" xsd:string [Term] id: UBERON:0007651 name: anatomical junction def: "An anatomical structure that connects two structures." [http://code.google.com/p/caro2/issues/detail?id=15] subset: common_anatomy subset: upper_level synonym: "anatomical junction" EXACT [] synonym: "junction" BROAD [] xref: FMA:5898 xref: SCTID:91833003 is_a: UBERON:0000061 {source="FMA"} ! anatomical structure relationship: RO:0002176 UBERON:0000061 ! connects anatomical structure relationship: RO:0002176 UBERON:0000061 {minCardinality="2"} ! connects anatomical structure property_value: RO:0002175 NCBITaxon:33090 property_value: RO:0002175 NCBITaxon:33208 property_value: RO:0002175 NCBITaxon:4751 property_value: skos:prefLabel "anatomical junction" xsd:string [Term] id: UBERON:0007652 name: esophageal sphincter def: "A sphincter that is part of an esophagus." [http://orcid.org/0000-0002-6601-2165] xref: SCTID:277765007 is_a: UBERON:0003832 ! esophagus muscle is_a: UBERON:0004590 ! sphincter muscle intersection_of: UBERON:0004590 ! sphincter muscle intersection_of: BFO:0000050 UBERON:0001043 ! part of esophagus property_value: IAO:0000116 "check for specific subtypes across species. Note mammals have upper and lower, but lower is really part of cardia and thus is not classified under here" xsd:string property_value: skos:prefLabel "esophageal sphincter" xsd:string [Term] id: UBERON:0007684 name: uriniferous tubule def: "Functional unit of the kidney that forms urine, consisting of two parts, the nephron and the collecting tubule." [ISBN:0073040584] xref: FMA:17691 is_a: BFO:0000002 is_a: UBERON:0003914 ! epithelial tube is_a: UBERON:0004819 ! kidney epithelium is_a: UBERON:0006555 ! excretory tube relationship: BFO:0000051 UBERON:0001232 ! has part collecting duct of renal tubule relationship: BFO:0000051 UBERON:0001285 ! has part nephron [Term] id: UBERON:0007685 name: region of nephron tubule synonym: "region of renal tubule" RELATED [FMA:17692] synonym: "renal tubule region" EXACT [FMA:17692] xref: FMA:17692 is_a: UBERON:0001231 ! nephron tubule relationship: BFO:0000050 UBERON:0001231 ! part of nephron tubule [Term] id: UBERON:0007687 name: kidney field def: "Region of the embryo into the area in which the kidney rudiment will develop." [DOI:10.1371/journal.pone.0099864, GO:0072004, GOC:mtg_kidney_jan10] synonym: "kidney anlage" RELATED [GOC:mtg_kidney_jan10] is_a: UBERON:0005291 ! embryonic tissue is_a: UBERON:0006598 ! presumptive structure is_a: UBERON:0007688 ! anlage intersection_of: UBERON:0007688 ! anlage intersection_of: RO:0002387 UBERON:0002113 ! has potential to develop into kidney relationship: RO:0002387 UBERON:0002113 ! has potential to develop into kidney [Term] id: UBERON:0007688 name: anlage def: "Anlagen are populations of contiguous cells, typically arranged in one plane, that are morphologically indistinct, but that already correspond in extent to a later organ/tissue." [FBbt:00005426, http://flybase.org/reports/FBrf0178740.html] subset: efo_slim synonym: "developmental field" EXACT [] synonym: "field" BROAD [] synonym: "future organ" RELATED [] synonym: "organ field" RELATED [] xref: AEO:0000170 xref: EFO:0001649 xref: EHDAA2:0003170 xref: FBbt:00005426 {sssom:mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"} xref: Wikipedia:Anlage_(biology) is_a: UBERON:0000479 {source="FBbt"} ! tissue is_a: UBERON:0005423 {source="AEO", source="FBbt"} ! developing anatomical structure property_value: skos:prefLabel "anlage" xsd:string [Term] id: UBERON:0007689 name: thyroid diverticulum def: "Endodermal bud derived from the endodermal epithelium of the embryonic pharyngeal floor[MP]. The thyroid diverticulum is the embryological structure from which thyroid follicular cells derive. It grows from the floor of the pharnyx[WP]." [MP:0004662, Wikipedia:Thyroid_diverticulum] synonym: "diverticulum thyroideum" RELATED OMO:0003011 [Wikipedia:Thyroid_diverticulum] synonym: "saccus thyroideus" RELATED OMO:0003011 [Wikipedia:Thyroid_diverticulum] xref: Wikipedia:Thyroid_diverticulum is_a: BFO:0000002 is_a: UBERON:0001048 ! primordium relationship: BFO:0000050 UBERON:0001042 {source="VHOG"} ! part of chordate pharynx relationship: RO:0002494 UBERON:0003091 ! transformation of thyroid primordium [Term] id: UBERON:0007690 name: early pharyngeal endoderm comment: relation conflict: ZFA vs EHDAA2. Note EHDAA2 term renamed to 'early PA endoderm' subset: efo_slim synonym: "early pharyngeal arch endoderm" EXACT [EHDAA2:0001457] synonym: "pharyngeal arch endoderm" RELATED [] synonym: "pharyngeal endoderm" RELATED [ZFA:0001104] synonym: "pharyngeal region endoderm" RELATED [EHDAA2:0001456] xref: EFO:0003626 xref: EHDAA2:0001457 xref: EHDAA:962 xref: TAO:0001104 xref: ZFA:0001104 is_a: UBERON:0003258 ! endoderm of foregut is_a: UBERON:0005291 ! embryonic tissue relationship: BFO:0000050 UBERON:0009722 {source="cjm"} ! part of entire pharyngeal arch endoderm property_value: seeAlso "http://dev.biologists.org/content/128/22/4573.full" xsd:anyURI property_value: skos:prefLabel "early pharyngeal endoderm" xsd:string [Term] id: UBERON:0007691 name: gustatory pore def: "The minute opening of a taste bud on the surface of the oral mucosa through which the gustatory hairs of the specialised neuroepithelial gustatory cells project." [http://www.mondofacto.com/facts/dictionary?gustatory+pore] synonym: "porus gustatorius" EXACT [http://www.mondofacto.com/facts/dictionary?gustatory+pore] synonym: "taste pore" EXACT [FMA:63589] xref: FMA:63589 xref: NCIT:C33738 xref: SCTID:368724008 xref: UMLS:C0226971 {source="ncithesaurus:Taste_Pore"} is_a: UBERON:0000161 {source="FMA"} ! orifice intersection_of: UBERON:0000161 ! orifice intersection_of: BFO:0000050 UBERON:0001727 ! part of taste bud relationship: BFO:0000050 UBERON:0001727 {source="FMA"} ! part of taste bud relationship: RO:0002150 UBERON:0000167 ! continuous with oral cavity property_value: foaf:depiction "https://upload.wikimedia.org/wikipedia/commons/0/0e/Taste_bud.svg" xsd:anyURI property_value: skos:prefLabel "gustatory pore" xsd:string [Term] id: UBERON:0007692 name: nucleus of thalamus def: "A nucleus of brain that is part of a thalamus." [OBOL:automatic] synonym: "nuclear complex of thalamus" RELATED [FMA:256693] synonym: "thalamic nucleus" EXACT [MA:0002992] xref: BTO:0002452 xref: EMAPA:35859 xref: FMA:256693 xref: MA:0002992 xref: SCTID:279115000 xref: Wikipedia:List_of_thalamic_nuclei is_a: UBERON:0006569 ! diencephalic nucleus intersection_of: UBERON:0002308 ! nucleus of brain intersection_of: BFO:0000050 UBERON:0001897 ! part of dorsal plus ventral thalamus relationship: BFO:0000050 UBERON:0001897 ! part of dorsal plus ventral thalamus property_value: IAO:0000116 "TODO - consider splitting nucleus and complex" xsd:string property_value: skos:prefLabel "nucleus of thalamus" xsd:string [Term] id: UBERON:0007699 name: tract of spinal cord def: "An axon tract that is part of a spinal cord." [OBOL:automatic] synonym: "spinal cord tract" EXACT [FMA:75683] xref: FMA:75683 xref: NCIT:C12995 xref: UMLS:C1519456 {source="ncithesaurus:Spinal_Cord_Tract"} is_a: UBERON:0001018 ! axon tract intersection_of: UBERON:0001018 ! axon tract intersection_of: BFO:0000050 UBERON:0002240 ! part of spinal cord relationship: BFO:0000050 UBERON:0002240 ! part of spinal cord relationship: BFO:0000050 UBERON:0002316 {source="cjm"} ! part of white matter property_value: skos:prefLabel "tract of spinal cord" xsd:string [Term] id: UBERON:0007702 name: tract of brain def: "An axon tract that is part of a brain." [OBOL:automatic] synonym: "brain tract" EXACT [FMA:83848] synonym: "landmark tracts" RELATED [DMBA:tracts] xref: FMA:83848 is_a: UBERON:0001018 ! axon tract intersection_of: UBERON:0001018 ! axon tract intersection_of: BFO:0000050 UBERON:0000955 ! part of brain relationship: BFO:0000050 UBERON:0000955 ! part of brain relationship: BFO:0000050 UBERON:0002316 {source="cjm"} ! part of white matter property_value: IAO:0000116 "the NIFSTD class 'nerve tract' is classified under 'regional part of brain', so it may seem like it belongs here, but actually includes spinal cord tracts" xsd:string property_value: skos:prefLabel "tract of brain" xsd:string [Term] id: UBERON:0007719 name: bone of reproductive organ def: "A bone that is part of a reproductive organ." [https://github.com/obophenotype/uberon/issues/1158, OBOL:automatic] synonym: "baculum" NARROW [] synonym: "os penis/os clitoris" RELATED [] is_a: UBERON:0001474 ! bone element is_a: UBERON:0005156 ! reproductive structure intersection_of: UBERON:0001474 ! bone element intersection_of: BFO:0000050 UBERON:0003133 ! part of reproductive organ relationship: BFO:0000050 UBERON:0003133 ! part of reproductive organ property_value: RO:0002161 NCBITaxon:9606 {source="Wikipedia"} property_value: skos:prefLabel "bone of reproductive organ" xsd:string [Term] id: UBERON:0007721 name: interphalangeal joint of pes def: "The interphalangeal articulations of the foot (articulations of the phalanges) are ginglymoid joints, and each has a plantar and two collateral ligaments. The arrangement of these ligaments is similar to that in the metatarsophalangeal articulations: the Extensor tendons supply the places of dorsal ligaments." [Wikipedia:Interphalangeal_articulations_of_the_foot] subset: pheno_slim synonym: "foot interphalangeal joint" EXACT [MESH:A02.835.583.378.900] synonym: "hindlimb digit inter-phalangeal joint" EXACT [EMAPA:36337] synonym: "interphalangeal joint of foot" EXACT [FMA:35225] synonym: "interphalangeal joint of toe" NARROW SENSU [FMA:35225, NCBITaxon:9606] synonym: "toe joint" RELATED [MESH:A02.835.583.378.900] xref: EMAPA:36337 xref: FMA:35225 xref: MESH:D014033 xref: NCIT:C32867 xref: NCIT:C33789 xref: SCTID:182225005 xref: UMLS:C0040356 {source="ncithesaurus:Interphalangeal_Joint_of_the_Foot"} xref: Wikipedia:Interphalangeal_articulations_of_the_foot is_a: UBERON:0001487 ! pes joint is_a: UBERON:0006658 ! interphalangeal joint intersection_of: UBERON:0006658 ! interphalangeal joint intersection_of: BFO:0000050 UBERON:0001466 ! part of pedal digit relationship: BFO:0000050 UBERON:0001466 ! part of pedal digit relationship: RO:0002176 UBERON:0001449 {cardinality="2"} ! connects phalanx of pes relationship: RO:0002176 UBERON:0001449 ! connects phalanx of pes [Term] id: UBERON:0007722 name: interphalangeal joint of manus def: "The interphalangeal articulations of hand are hinge-joints of the phalanges of the hand. There are two sets (except in the thumb): 'proximal interphalangeal joints' (PIP), those between the first (also called proximal) and second (intermediate) phalanges 'distal interphalangeal joints' (DIP), those between the second and third (distal) phalanges A similar group of articulations also function in the toes." [Wikipedia:Interphalangeal_articulations_of_the_hand] subset: pheno_slim synonym: "articulationes digitorum manus" EXACT [Wikipedia:Interphalangeal_articulations_of_the_hand] synonym: "articulationes interphalangeae manus" EXACT [Wikipedia:Interphalangeal_articulations_of_the_hand] synonym: "articulations of the digits" RELATED [Wikipedia:Interphalangeal_articulations_of_the_hand] synonym: "interphalangeal articulations of hand" RELATED [Wikipedia:Interphalangeal_articulations_of_the_hand] synonym: "interphalangeal joint of finger" NARROW SENSU [FMA:35285, NCBITaxon:9606] synonym: "interphalangeal joint of hand" EXACT [FMA:35285] synonym: "interphalangeal joints of hand" RELATED [Wikipedia:Interphalangeal_articulations_of_the_hand] synonym: "IP joint" RELATED [FMA:35285] xref: EMAPA:36336 xref: FMA:35285 xref: NCIT:C32868 xref: SCTID:303280009 xref: UMLS:C0016125 {source="ncithesaurus:Interphalangeal_Joint_of_the_Hand"} xref: Wikipedia:Interphalangeal_articulations_of_the_hand is_a: UBERON:0001489 ! manus joint is_a: UBERON:0006658 ! interphalangeal joint intersection_of: UBERON:0006658 ! interphalangeal joint intersection_of: BFO:0000050 UBERON:0002389 ! part of manual digit relationship: BFO:0000050 UBERON:0002389 ! part of manual digit relationship: RO:0002176 UBERON:0001436 {cardinality="2"} ! connects phalanx of manus relationship: RO:0002176 UBERON:0001436 ! connects phalanx of manus property_value: IAO:0000116 "consider renaming: 'finger' is ambiguous as the term in some usages excludes the thumb (we include it)" xsd:string [Term] id: UBERON:0007771 name: epidermis gland def: "A gland that is part of a epidermis." [OBOL:automatic] subset: grouping_class synonym: "epidermal gland" EXACT [] synonym: "gland of epidermis" EXACT [FMA:59153] xref: FMA:59153 is_a: UBERON:0002419 ! skin gland intersection_of: UBERON:0002530 ! gland intersection_of: BFO:0000050 UBERON:0001003 ! part of skin epidermis relationship: BFO:0000050 UBERON:0001003 ! part of skin epidermis property_value: skos:prefLabel "epidermis gland" xsd:string [Term] id: UBERON:0007777 name: umbilical vein endothelium def: "An endothelium that is part of a umbilical vein." [OBOL:automatic] xref: BTO:0001416 xref: CALOHA:TS-1081 is_a: UBERON:0001919 ! endothelium of vein intersection_of: UBERON:0001986 ! endothelium intersection_of: BFO:0000050 UBERON:0002066 ! part of umbilical vein relationship: BFO:0000050 UBERON:0002066 {source="BTO"} ! part of umbilical vein [Term] id: UBERON:0007778 name: umbilical artery endothelium def: "An endothelium that is part of a umbilical artery." [OBOL:automatic] xref: BTO:0000857 is_a: UBERON:0001917 ! endothelium of artery intersection_of: UBERON:0001986 ! endothelium intersection_of: BFO:0000050 UBERON:0001310 ! part of umbilical artery relationship: BFO:0000050 UBERON:0001310 {source="BTO"} ! part of umbilical artery [Term] id: UBERON:0007779 name: transudate def: "Any bodily fluid that has passed through a membrane such as the capillary wall, as a result of unbalanced hydrostatic and osmotic forces." [http://medical-dictionary.thefreedictionary.com/transudate] synonym: "plasma ultrafiltrate" RELATED [] xref: FMA:12276 xref: GAID:1195 xref: MESH:D005122 xref: ncithesaurus:Transudate is_a: BFO:0000002 is_a: UBERON:0006314 ! bodily fluid intersection_of: UBERON:0000463 ! organism substance intersection_of: filtered_through UBERON:0001982 ! capillary intersection_of: RO:0000086 PATO:0001548 ! has quality quality of a liquid intersection_of: RO:0002494 UBERON:0001969 ! transformation of blood plasma relationship: filtered_through UBERON:0001982 ! capillary relationship: RO:0002162 NCBITaxon:7742 ! in taxon Vertebrata relationship: RO:0002494 UBERON:0001969 ! transformation of blood plasma property_value: skos:prefLabel "transudate" xsd:string [Term] id: UBERON:0007794 name: secretion of serous gland def: "Any fluid produced by a serous gland." [UBERON:cjm] synonym: "serosal fluid" EXACT [Wikipedia:Serous_fluid] synonym: "serous fluid" BROAD [] synonym: "serous gland fluid" EXACT [] xref: Wikipedia:Serous_fluid is_a: UBERON:0000456 ! secretion of exocrine gland is_a: UBERON:0006314 ! bodily fluid intersection_of: UBERON:0006314 ! bodily fluid intersection_of: RO:0003001 UBERON:0000409 ! produced by serous gland relationship: RO:0003001 UBERON:0000409 ! produced by serous gland property_value: skos:prefLabel "secretion of serous gland" xsd:string [Term] id: UBERON:0007798 name: vascular system def: "Anatomical system that consists of all blood and lymph vessels." [http://orcid.org/0000-0002-6601-2165] subset: human_reference_atlas subset: pheno_slim xref: BTO:0001085 xref: CALOHA:TS-2053 xref: EHDAA2:0004520 xref: EMAPA:35905 xref: MA:0002718 xref: NCIT:C33854 xref: UMLS:C0489903 {source="ncithesaurus:Vascular_System"} is_a: UBERON:0000467 ! anatomical system relationship: BFO:0000050 UBERON:0004535 {source="MA"} ! part of cardiovascular system property_value: IAO:0000116 "consider merging with vasculature" xsd:string property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "vascular system" xsd:string [Term] id: UBERON:0007806 name: connecting stalk def: "A bridge of mesoderm connecting the caudal end of the young embryo with the trophoblastic tissues; the precursor of the umbilical cord." [http://medical-dictionary.thefreedictionary.com/] xref: BTO:0004705 xref: NCIT:C34132 xref: UMLS:C1516792 {source="ncithesaurus:Connecting_Stalk"} is_a: BFO:0000002 is_a: UBERON:0000478 {source="EHDAA2"} ! extraembryonic structure relationship: RO:0002202 UBERON:0005728 {source="EHDAA2"} ! develops from extraembryonic mesoderm property_value: IAO:0000116 "TODO - this is currently defined as a bridge of mesoderm, but in EHDAA2 is extraembryonic structure split into mesoderm and blood vessels" xsd:string [Term] id: UBERON:0007807 name: connecting stalk vasculature def: "A vasculature that is part of a connecting stalk." [OBOL:automatic] synonym: "connecting stalk blood vessel" RELATED [] synonym: "connecting stalk blood vessels" EXACT [EHDAA2:0000313] synonym: "vasculature of connecting stalk" RELATED [] xref: EHDAA2:0000313 is_a: BFO:0000002 is_a: UBERON:0002049 ! vasculature intersection_of: UBERON:0002049 ! vasculature intersection_of: BFO:0000050 UBERON:0007806 ! part of connecting stalk relationship: BFO:0000050 UBERON:0007806 ! part of connecting stalk relationship: RO:0002202 UBERON:0011921 {source="EHDAA2"} ! develops from connecting stalk blood islands [Term] id: UBERON:0007808 name: adipose tissue of abdominal region def: "Adipose tissue that is located in the abdominal region. This includes any subcutaneous fat, visceral fat or encapsulated adipose tissue depots." [CALOHA:paula, http://orcid.org/0000-0002-6601-2165, https://github.com/obophenotype/uberon/issues/259, MGI:csmith] subset: efo_slim synonym: "abdominal adipose tissue" RELATED [BTO:0004041] synonym: "abdominal fat" RELATED [BTO:0004041] synonym: "intra-abdominal fat" RELATED [BTO:0004041] xref: CALOHA:TS-0002 xref: EFO:0003771 is_a: UBERON:0001013 ! adipose tissue is_a: UBERON:0003567 ! abdomen connective tissue intersection_of: UBERON:0001013 ! adipose tissue intersection_of: BFO:0000050 UBERON:0000916 ! part of abdomen property_value: skos:prefLabel "adipose tissue of abdominal region" xsd:string property_value: terms:contributor https://orcid.org/0000-0002-0819-0473 property_value: terms:contributor https://orcid.org/0000-0002-6601-2165 [Term] id: UBERON:0007811 name: craniocervical region def: "The anteriormost subdivision of the body that includes the head, jaws, pharyngeal region and the neck (if present). In vertebrates this is the subdivision that includes the cervical vertebrae." [https://orcid.org/0000-0002-6601-2165] subset: pheno_slim synonym: "cephalic area" RELATED [https://github.com/obophenotype/uberon/issues/379] synonym: "cephalic part of animal" RELATED [Wikipedia:Head] synonym: "cephalic region" RELATED [https://github.com/obophenotype/uberon/issues/379] synonym: "head and neck" RELATED [FMA:280881] synonym: "head or neck" RELATED [] xref: CALOHA:TS-2356 xref: EV:0100009 xref: FMA:280881 xref: galen:HeadAndNeck xref: MA:0000006 xref: NCIT:C12418 xref: SCTID:361355005 xref: UMLS:C0460004 {source="ncithesaurus:Head_and_Neck"} xref: WikipediaCategory:Head_and_neck xref: ZFA:0001114 is_a: UBERON:0000475 {source="MA"} ! organism subdivision relationship: BFO:0000050 UBERON:0000153 ! part of anterior region of body relationship: BFO:0000050 UBERON:0013702 ! part of body proper relationship: BFO:0000051 UBERON:0000033 ! has part head relationship: BFO:0000051 UBERON:0006562 ! has part pharynx property_value: skos:prefLabel "craniocervical region" xsd:string [Term] id: UBERON:0007812 name: post-anal tail def: "A tail that extends from the posterior tip of the organism to the anus, contains muscle and skeleton." [https://orcid.org/0000-0002-6601-2165] subset: pheno_slim subset: vertebrate_core synonym: "muscular postanal tail" EXACT [] synonym: "post-anal fin tail" NARROW SENSU [http://purl.oboibrary.org/obo/uberon/tracker/185] synonym: "post-vent region" RELATED [TAO:0001117] synonym: "postanal tail" EXACT [] xref: AAO:0010338 xref: MA:0000008 xref: NCIT:C77663 xref: TAO:0001117 xref: UMLS:C0039259 {source="ncithesaurus:Tail"} xref: XAO:0003026 xref: ZFA:0001117 is_a: BFO:0000002 is_a: UBERON:0002415 ! tail intersection_of: UBERON:0002415 ! tail intersection_of: BFO:0000050 UBERON:0006071 ! part of caudal region relationship: BFO:0000050 UBERON:0006071 ! part of caudal region relationship: RO:0002216 GO:0007626 ! capable of part of locomotory behavior relationship: RO:0002494 UBERON:0007144 ! transformation of embryonic post-anal tail property_value: RO:0002161 NCBITaxon:314295 property_value: skos:prefLabel "post-anal tail" xsd:string [Term] id: UBERON:0007823 name: appendage girdle region def: "An organism subdivision that encompasses the region containing the pectoral or pelvic girdle. Note that this includes both the skeletal elements and associated tissues (integument, muscle, etc)." [https://orcid.org/0000-0002-6601-2165, UBERONREF:0000003] synonym: "fin girdle" RELATED SENSU [] synonym: "fin girdle region" RELATED SENSU [] synonym: "girdle" BROAD [] synonym: "girdle region" BROAD [] synonym: "limb girdle" RELATED SENSU [] synonym: "limb girdle region" RELATED SENSU [] xref: EMAPA:37854 {source="MA:th"} xref: FMA:24874 xref: VSAO:0000303 is_a: UBERON:0000475 ! organism subdivision intersection_of: UBERON:0000475 ! organism subdivision intersection_of: RO:0002551 UBERON:0010719 ! has skeleton girdle skeleton relationship: BFO:0000050 UBERON:0010707 ! part of appendage girdle complex relationship: RO:0002551 UBERON:0010719 ! has skeleton girdle skeleton property_value: skos:prefLabel "appendage girdle region" xsd:string [Term] id: UBERON:0007826 name: peritoneal mesentery def: "Mesentery that is located in the peritoneum." [UBERON:cjm] xref: FMA:20570 xref: TAO:0005129 xref: XAO:0000138 xref: ZFA:0005129 is_a: UBERON:0002095 ! mesentery is_a: UBERON:0002358 ! peritoneum intersection_of: UBERON:0002095 ! mesentery intersection_of: BFO:0000050 UBERON:0002358 ! part of peritoneum relationship: BFO:0000050 UBERON:0001178 {source="FMA"} ! part of visceral peritoneum [Term] id: UBERON:0007827 name: external nose def: "External part of the nose containing the external nares." [http://orcid.org/0000-0002-6601-2165] subset: pheno_slim synonym: "nose" RELATED [] xref: EMAPA:37831 {source="MA:th"} xref: FMA:59515 xref: NCIT:C32566 xref: SCTID:265785009 xref: UMLS:C0458561 {source="ncithesaurus:External_Nose"} is_a: UBERON:0034929 ! external soft tissue zone intersection_of: UBERON:0034929 ! external soft tissue zone intersection_of: BFO:0000050 UBERON:0000004 ! part of nose intersection_of: BFO:0000051 UBERON:0005928 ! has part external naris relationship: BFO:0000050 UBERON:0000004 ! part of nose relationship: BFO:0000051 UBERON:0005928 ! has part external naris [Term] id: UBERON:0007828 name: girdle bone/zone def: "A bone that is part of a appendage girdle region." [OBOL:automatic] synonym: "girdle bone" EXACT [MA:0000291] xref: EMAPA:35379 xref: MA:0000291 is_a: UBERON:0010740 ! bone of appendage girdle complex intersection_of: UBERON:0001474 ! bone element intersection_of: BFO:0000050 UBERON:0007823 ! part of appendage girdle region relationship: BFO:0000050 UBERON:0010719 ! part of girdle skeleton property_value: skos:prefLabel "girdle bone/zone" xsd:string [Term] id: UBERON:0007829 name: pectoral girdle bone def: "A bone that is part of a pectoral girdle region." [OBOL:automatic] subset: human_reference_atlas subset: vertebrate_core synonym: "bone of pectoral girdle" EXACT [] xref: EMAPA:35669 xref: MA:0000292 is_a: UBERON:0007828 {source="MA"} ! girdle bone/zone is_a: UBERON:0010741 ! bone of pectoral complex intersection_of: UBERON:0001474 ! bone element intersection_of: BFO:0000050 UBERON:0001421 ! part of pectoral girdle region relationship: BFO:0000050 UBERON:0007831 ! part of pectoral girdle skeleton property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "pectoral girdle bone" xsd:string [Term] id: UBERON:0007830 name: pelvic girdle bone/zone def: "A bone element or fused bone that is part of pelvic girdle." [https://orcid.org/0000-0002-6601-2165] subset: human_reference_atlas subset: pheno_slim subset: vertebrate_core synonym: "bone of pelvic girdle" EXACT [] synonym: "pelvic girdle bone" EXACT [MA:0000293] xref: MA:0000293 xref: NCIT:C33287 xref: SCTID:426214007 xref: UMLS:C0030786 {source="ncithesaurus:Pelvic_Bone"} is_a: UBERON:0003828 ! abdominal segment bone is_a: UBERON:0005179 ! pelvic region element is_a: UBERON:0005913 ! zone of bone organ is_a: UBERON:0007828 {source="MA"} ! girdle bone/zone is_a: UBERON:0010742 ! bone of pelvic complex intersection_of: UBERON:0001474 ! bone element intersection_of: BFO:0000050 UBERON:0007832 ! part of pelvic girdle skeleton relationship: BFO:0000050 UBERON:0007832 ! part of pelvic girdle skeleton property_value: IAO:0000116 "check sacrum, coccyx (MA does NOT include these)" xsd:string property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0007831 name: pectoral girdle skeleton def: "A subdivision of a limb or fin skeleton consisting of bones which connects the upper limb or fin to the axial skeleton on each side. It consists of the clavicle and scapula in humans and, in those species with three bones in the pectoral girdle, the coracoid. Some mammalian species (e.g. the dog and the horse) have only the scapula. In humans, the only joints between the shoulder girdle and axial skeleton are the sternoclavicular joints on each side. No joint exists between each scapula and the rib cage; instead the muscular connection between the two permits relatively great mobility of the shoulder girdle in relation to the pelvic girdle. In those species having only the scapula, no joint exists between the forelimb and the thorax, the only attachment being muscular[WP]. Examples: There are only two instances, right and left pectoral girdle skeletons." [Wikipedia:Pectoral_girdle] subset: efo_slim subset: vertebrate_core synonym: "cingulum pectorale" RELATED OMO:0003011 [Wikipedia:Pectoral_girdle] synonym: "pectoral girdle" RELATED INCONSISTENT [VSAO:0000156] synonym: "scapular girdle" RELATED [TAO:0000407] synonym: "skeletal parts of pectoral girdle" EXACT [https://orcid.org/0000-0002-6601-2165] synonym: "skeleton of pectoral girdle" EXACT [https://orcid.org/0000-0002-6601-2165] xref: AAO:0000422 xref: AAO:0000754 xref: EFO:0000946 xref: EHDAA2:0001420 xref: FMA:24141 xref: MAT:0000181 xref: MIAA:0000181 xref: NCIT:C33547 xref: TAO:0000407 xref: UMLS:C0427245 {source="ncithesaurus:Shoulder_Girdle"} xref: VHOG:0001156 xref: VSAO:0000156 xref: Wikipedia:Pectoral_girdle xref: XAO:0003063 xref: ZFA:0000407 is_a: UBERON:0010719 ! girdle skeleton intersection_of: UBERON:0010912 ! subdivision of skeleton intersection_of: BFO:0000050 UBERON:0001421 ! part of pectoral girdle region intersection_of: RO:0002576 UBERON:0001421 ! skeleton of pectoral girdle region relationship: BFO:0000050 UBERON:0012475 ! part of skeleton of pectoral complex relationship: RO:0002576 UBERON:0001421 ! skeleton of pectoral girdle region property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/2/22/Pectoral_girdle_front_diagram.svg" xsd:anyURI property_value: skos:prefLabel "pectoral girdle skeleton" xsd:string [Term] id: UBERON:0007832 name: pelvic girdle skeleton def: "Skeletal subdivision consisting of a set of bones linking the axial series to the hindlimb zeugopodium and offering anchoring areas for hindlimb and caudal musculature." [VSAO:0000155, Wikipedia:Pelvis] subset: efo_slim subset: vertebrate_core synonym: "pelvic girdle" RELATED INCONSISTENT [VSAO:0000155] synonym: "pelvic girdle skeleton" EXACT [VSAO:0000155] synonym: "skeletal parts of pelvic girdle" EXACT [https://orcid.org/0000-0002-6601-2165] synonym: "skeleton of pelvic girdle" EXACT [https://orcid.org/0000-0002-6601-2165] xref: AAO:0000426 xref: AAO:0000768 xref: EFO:0000947 xref: EHDAA2:0001426 xref: EHDAA:7149 xref: EHDAA:8324 xref: EMAPA:18028 xref: FMA:87592 xref: galen:PelvicGirdle xref: http://people.eku.edu/ritchisong/pectoralgirdles.gif xref: MAT:0000182 xref: MIAA:0000182 xref: TAO:0000565 xref: VHOG:0000305 xref: VSAO:0000155 xref: Wikipedia:Pelvis xref: XAO:0003064 xref: ZFA:0000565 is_a: BFO:0000002 is_a: UBERON:0010719 ! girdle skeleton intersection_of: UBERON:0010912 ! subdivision of skeleton intersection_of: BFO:0000050 UBERON:0001271 ! part of pelvic girdle region intersection_of: RO:0002576 UBERON:0001271 ! skeleton of pelvic girdle region relationship: BFO:0000050 UBERON:0012476 ! part of skeleton of pelvic complex relationship: RO:0002202 UBERON:0010377 {source="PMID:21455939"} ! develops from mesenchyme from somatopleure relationship: RO:0002576 UBERON:0001271 ! skeleton of pelvic girdle region property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/f/fe/Gray242.png" xsd:anyURI property_value: IAO:0000116 "need to resolve whether this is a paired structure or a single belt (Paired in FMA - implicitly paired in VSAO)" xsd:string [Term] id: UBERON:0007842 name: membrane bone def: "Bone element that arises as a result of intramembranous ossification." [GO_REF:0000034, http://dx.plos.org/10.1371/journal.pone.0051070, https://github.com/obophenotype/uberon/issues/267, VSAO:0000023] synonym: "membrane bones" RELATED OMO:0003004 [ZFA:0001636] xref: AEO:0000085 xref: EHDAA2:0003085 xref: TAO:0001645 xref: VSAO:0000023 xref: XAO:0004014 xref: ZFA:0001636 is_a: UBERON:0001474 {source="VSAO"} ! bone element relationship: RO:0002353 GO:0001957 ! output of intramembranous ossification property_value: skos:prefLabel "membrane bone" xsd:string [Term] id: UBERON:0007844 name: cartilage element def: "Skeletal element that is composed of cartilage tissue and may be permanent or transient." [GO_REF:0000034, http://dx.plos.org/10.1371/journal.pone.0051070, PSPUB:0000170, VSAO:0000000] subset: organ_slim subset: pheno_slim synonym: "cartilage" RELATED [VSAO:0000000] synonym: "cartilage organ" EXACT [FMA:55107] synonym: "cartilaginous element" EXACT [https://orcid.org/0000-0002-6601-2165] synonym: "chondrogenic element" EXACT [VSAO:0000000] xref: AAO:0011130 xref: CALOHA:TS-0118 xref: FMA:55107 xref: VSAO:0000000 xref: XAO:0004013 xref: ZFA:0001501 is_a: BFO:0000002 is_a: UBERON:0004765 {source="VSAO"} ! skeletal element intersection_of: UBERON:0004765 ! skeletal element intersection_of: RO:0002473 UBERON:0002418 ! composed primarily of cartilage tissue relationship: RO:0002202 UBERON:0005863 {source="VSAO"} ! develops from cartilaginous condensation relationship: RO:0002473 UBERON:0002418 ! composed primarily of cartilage tissue property_value: skos:prefLabel "cartilage element" xsd:string [Term] id: UBERON:0007845 name: regular connective tissue def: "Connective tissue, which consists of fibroblasts, the intercellular matrix of which contains a regular network of collagen and elastic fiber bundles. Examples: bone (tissue), cartilage (tissue), dense regular connective tissue." [FMA:20103] xref: FMA:20103 is_a: BFO:0000002 is_a: UBERON:0002384 {source="FMA"} ! connective tissue disjoint_from: UBERON:0011821 ! irregular connective tissue relationship: BFO:0000051 CL:0000057 ! has part fibroblast relationship: BFO:0000051 GO:0071953 ! has part elastic fiber relationship: BFO:0000051 UBERON:0011860 ! has part collection of collagen fibrils property_value: IAO:0000116 "the connective tissue hierarchy largely follows FMA with definitions from VSAO. Note that in FMA, loose-CT is irregular-CT. This means regular-CT is necessarily equivalent to dense-regular-CT (assuming a JEPD classification)." xsd:string property_value: skos:prefLabel "regular connective tissue" xsd:string [Term] id: UBERON:0007846 name: dense regular connective tissue def: "Connective tissue that is dominated by collagen fibres organized into a definitive pattern (e.g., parallel to one another), with comparatively fewer cells (mostly fibroblasts)." [GO_REF:0000034, http://dx.plos.org/10.1371/journal.pone.0051070, PSPUB:0000170, VSAO:0000050] synonym: "dense fibrous connective tissue" EXACT [FMA:64781] synonym: "dense regular collagenous connective tissue" EXACT [FMA:64781] synonym: "dense regular collagenous tissue" EXACT [FMA:64781] synonym: "regular dense connective tissue" EXACT [] synonym: "typus regularis (textus connectivus collagenosus compactus)" EXACT [FMA:64781] xref: FMA:64781 xref: NCIT:C33453 xref: SCTID:22560007 xref: UMLS:C0225333 {source="ncithesaurus:Regular_Dense_Connective_Tissue"} xref: VSAO:0000050 xref: Wikipedia:Dense_regular_connective_tissue xref: XAO:0004030 is_a: UBERON:0007845 {source="FMA"} ! regular connective tissue is_a: UBERON:0011823 {source="ncithesaurus"} ! dense connective tissue intersection_of: UBERON:0007845 ! regular connective tissue intersection_of: BFO:0000051 GO:0071953 ! has part elastic fiber intersection_of: RO:0002473 UBERON:0011860 ! composed primarily of collection of collagen fibrils property_value: skos:prefLabel "dense regular connective tissue" xsd:string [Term] id: UBERON:0007914 name: bone of craniocervical region def: "A bone that is part of a craniocervical region." [OBOL:automatic] synonym: "cranial bone" RELATED [] synonym: "head or neck bone" EXACT [MA:0000569] xref: EMAPA:37245 {source="MA:th"} xref: MA:0000569 is_a: UBERON:0001474 {source="MA"} ! bone element intersection_of: UBERON:0001474 ! bone element intersection_of: BFO:0000050 UBERON:0007811 ! part of craniocervical region relationship: BFO:0000050 UBERON:0007811 {source="MA"} ! part of craniocervical region property_value: skos:prefLabel "bone of craniocervical region" xsd:string [Term] id: UBERON:0007997 name: sesamoid bone of manus def: "A sesamoid bone that is part of a manus." [OBOL:automatic] synonym: "sesamoid bone of hand" EXACT [FMA:42353] xref: FMA:42353 xref: SCTID:368448000 is_a: UBERON:0001479 {source="FMA"} ! sesamoid bone is_a: UBERON:0005897 ! manus bone is_a: UBERON:0011141 ! appendicular ossicle intersection_of: UBERON:0001479 ! sesamoid bone intersection_of: BFO:0000050 UBERON:0002398 ! part of manus [Term] id: UBERON:0008000 name: sesamoid bone of pes def: "A sesamoid bone that is part of a pes." [OBOL:automatic] synonym: "sesamoid bone of foot" EXACT [FMA:45096] xref: FMA:45096 xref: SCTID:244675002 is_a: UBERON:0001479 {source="FMA"} ! sesamoid bone is_a: UBERON:0005899 ! pes bone is_a: UBERON:0011141 ! appendicular ossicle intersection_of: UBERON:0001479 ! sesamoid bone intersection_of: BFO:0000050 UBERON:0002387 ! part of pes [Term] id: UBERON:0008001 name: irregular bone def: "The irregular bones are bones which, from their peculiar form, cannot be grouped as long bone, short bone, flat bone or sesamoid bone. Irregular bones serve various purposes in the body, such as protection of nervous tissue, affording multiple anchor points for skeletal muscle attachment (as with the sacrum), and maintaining pharynx and trachea support, and tongue attachment (such as the hyoid bone). They consist of cancellous tissue enclosed within a thin layer of compact bone. The irregular bones are: the vertebrC&, sacrum, coccyx, temporal, sphenoid, ethmoid, zygomatic, maxilla, mandible, palatine, inferior nasal concha, and hyoid." [Wikipedia:Irregular_bone] synonym: "os irregulare" EXACT [] synonym: "os irregulare" RELATED OMO:0003011 [Wikipedia:Irregular_bone] xref: FMA:7477 xref: NCIT:C32881 xref: SCTID:421560006 xref: UMLS:C0502414 {source="ncithesaurus:Irregular_Bone"} xref: Wikipedia:Irregular_bone is_a: UBERON:0001474 {source="FMA"} ! bone element property_value: skos:prefLabel "irregular bone" xsd:string [Term] id: UBERON:0008114 name: joint of girdle def: "A skeletal joint that is part of a appendage girdle region." [OBOL:automatic] subset: grouping_class synonym: "girdle joint" EXACT [OBOL:automatic] xref: MA:0001505 is_a: UBERON:0000982 {source="MA"} ! skeletal joint intersection_of: UBERON:0000982 ! skeletal joint intersection_of: BFO:0000050 UBERON:0007823 ! part of appendage girdle region relationship: BFO:0000050 UBERON:0007823 ! part of appendage girdle region relationship: RO:0002176 UBERON:0007828 ! connects girdle bone/zone property_value: skos:prefLabel "joint of girdle" xsd:string [Term] id: UBERON:0008115 name: surface of cartilage def: "An anatomical surface that is part of a cartilage element." [OBOL:automatic] synonym: "cartilage surface" EXACT [FMA:76668] xref: FMA:76668 is_a: UBERON:0036215 ! anatomical surface region intersection_of: UBERON:0036215 ! anatomical surface region intersection_of: RO:0002007 UBERON:0007844 ! bounding layer of cartilage element relationship: RO:0002007 UBERON:0007844 ! bounding layer of cartilage element property_value: skos:prefLabel "surface of cartilage" xsd:string [Term] id: UBERON:0008187 name: hypertrophic cartilage zone comment: see also VSAO:0000098 xref: EMAPA:35415 xref: MA:0002849 is_a: UBERON:0002418 ! cartilage tissue relationship: BFO:0000050 UBERON:0004763 {source="MA"} ! part of endochondral bone tissue [Term] id: UBERON:0008193 name: pneumatized bone def: "A bone that is hollow or contains many air cells, such as the mastoid process of the temporal bone[TMD]." [http://www.medilexicon.com/medicaldictionary.php?t=11303] synonym: "hollow bone" RELATED [] synonym: "os pneumaticum" EXACT [FMA:7478] synonym: "pneumatic bone" EXACT [FMA:7478] xref: FMA:7478 xref: galen:PneumaticBone xref: SCTID:333008005 xref: Wikipedia:Skeletal_pneumaticity is_a: UBERON:0001474 ! bone element intersection_of: UBERON:0001474 ! bone element intersection_of: BFO:0000051 UBERON:0010528 ! has part pneumatic cavity of bone relationship: BFO:0000051 UBERON:0010528 ! has part pneumatic cavity of bone property_value: IAO:0000116 "subclasses of this should be checked for taxonomic consistency" xsd:string property_value: skos:prefLabel "pneumatized bone" xsd:string [Term] id: UBERON:0008196 name: muscle of pectoral girdle def: "Any muscle organ that is part of a pectoral girdle region." [OBOL:automatic] subset: pheno_slim synonym: "muscle of shoulder girdle" EXACT [FMA:37347] synonym: "pectoral girdle muscle" EXACT [FMA:37347] xref: FMA:37347 is_a: UBERON:0010891 ! pectoral complex muscle intersection_of: UBERON:0014892 ! skeletal muscle organ, vertebrate intersection_of: BFO:0000050 UBERON:0001421 ! part of pectoral girdle region relationship: BFO:0000050 UBERON:0004471 ! part of musculature of pectoral girdle property_value: skos:prefLabel "muscle of pectoral girdle" xsd:string [Term] id: UBERON:0008198 name: nail plate def: "The nail plate is the hard and translucent portion of the nail, composed of keratin." [https://github.com/obophenotype/uberon/issues/20, https://sourceforge.net/p/geneontology/ontology-requests/8479/, Wikipedia:Nail_plate] subset: human_reference_atlas synonym: "lamina unguis" RELATED OMO:0003011 [Wikipedia:Nail_plate] xref: EMAPA:35583 xref: MA:0002708 xref: NCIT:C34216 xref: SCTID:372177002 xref: Wikipedia:Nail_plate is_a: BFO:0000002 is_a: UBERON:0013754 ! integumentary system layer relationship: BFO:0000050 UBERON:0001705 {source="MA"} ! part of nail relationship: BFO:0000051 CL:0000312 ! has part keratinocyte property_value: foaf:depiction "https://upload.wikimedia.org/wikipedia/commons/9/9f/Fingernail_label.jpg" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 property_value: terms:contributor https://orcid.org/0000-0002-6601-2165 [Term] id: UBERON:0008202 name: bone of hip region subset: grouping_class subset: non_informative subset: pheno_slim xref: EMAPA:37308 {source="MA:th"} xref: FMA:42854 xref: MA:0000655 xref: SCTID:304907005 is_a: UBERON:0001474 ! bone element relationship: RO:0002131 UBERON:0001464 {source="MA"} ! overlaps hip property_value: IAO:0000116 "todo - consider obsoletion" xsd:string [Term] id: UBERON:0008203 name: pelvic cavity def: "The part of the ventral body cavity that is within the pelvis." [UBERON:cjm] synonym: "cavitas pelvis" RELATED OMO:0003011 [Wikipedia:Pelvic_cavity] synonym: "space of pelvic compartment" EXACT [FMA:9738] xref: EMAPA:37235 {source="MA:th"} xref: FMA:9738 xref: MA:0003089 xref: SCTID:281903009 xref: Wikipedia:Pelvic_cavity is_a: UBERON:0002553 ! anatomical cavity intersection_of: UBERON:0002553 ! anatomical cavity intersection_of: BFO:0000050 UBERON:0002323 ! part of coelemic cavity lumen intersection_of: RO:0002572 UBERON:0002355 ! luminal space of pelvic region of trunk relationship: BFO:0000050 UBERON:0035819 ! part of abdominopelvic cavity relationship: RO:0002572 UBERON:0002355 ! luminal space of pelvic region of trunk property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/e/ee/Scheme_body_cavities-en.svg" xsd:anyURI [Term] id: UBERON:0008229 name: craniocervical region musculature def: "Musculature system of the pharyngeal and head regions." [ZFA:0000328, ZFA:curator] synonym: "head muscles" RELATED [ZFA:0000328] synonym: "head or neck muscle" EXACT [MA:0000571] synonym: "head or neck muscle" RELATED [MA:0000571] xref: EMAPA:37259 {source="MA:th"} xref: MA:0000571 xref: TAO:0000328 xref: ZFA:0000328 is_a: UBERON:0001015 {source="MA"} ! musculature intersection_of: UBERON:0001015 ! musculature intersection_of: BFO:0000050 UBERON:0007811 ! part of craniocervical region relationship: BFO:0000050 UBERON:0007811 {source="MA"} ! part of craniocervical region property_value: skos:prefLabel "craniocervical region musculature" xsd:string [Term] id: UBERON:0008231 name: dorsal thoracic segment of trunk def: "Subdivision of thorax, which in humans is the posterior part of the thorax and is demarcated from the chest by the external surface of the posterolateral part of the rib cage and the anterior surface of the thoracic vertebral column; together with the chest, it constitutes the thorax." [FMA:24217] synonym: "back of thorax" RELATED [FMA:24217] synonym: "dorsum of thorax" EXACT [FMA:24217] synonym: "posterior part of thorax" EXACT [FMA:24217] synonym: "thoracic back" EXACT [FMA:24217] synonym: "thoracic part of back" EXACT [FMA:24217] synonym: "upper back" EXACT [MA:0000028] xref: EMAPA:37234 {source="MA:th"} xref: FMA:24217 xref: MA:0000028 xref: SCTID:362666008 is_a: UBERON:0000475 ! organism subdivision relationship: BFO:0000050 UBERON:0000915 {source="FMA", source="MA"} ! part of thoracic segment of trunk relationship: BFO:0000050 UBERON:0011270 {source="FMA"} ! part of dorsal trunk property_value: skos:prefLabel "dorsal thoracic segment of trunk" xsd:string [Term] id: UBERON:0008242 name: lower back muscle def: "A muscle of back that is part of a lower back." [OBOL:automatic] xref: EMAPA:37262 {source="MA:th"} xref: MA:0000502 xref: SCTID:317178000 is_a: UBERON:0002324 ! muscle of back is_a: UBERON:0003833 {source="MA"} ! abdominal segment muscle intersection_of: UBERON:0002324 ! muscle of back intersection_of: BFO:0000050 UBERON:0005462 ! part of lower back relationship: BFO:0000050 UBERON:0005462 {source="MA"} ! part of lower back [Term] id: UBERON:0008243 name: upper back muscle def: "A muscle of back that is part of a dorsal thoracic segment of trunk." [OBOL:automatic] xref: EMAPA:37261 {source="MA:th"} xref: MA:0000508 xref: SCTID:305071003 is_a: UBERON:0002324 ! muscle of back is_a: UBERON:0003830 {source="MA"} ! thoracic segment muscle intersection_of: UBERON:0002324 ! muscle of back intersection_of: BFO:0000050 UBERON:0008231 ! part of dorsal thoracic segment of trunk relationship: BFO:0000050 UBERON:0008231 {source="MA"} ! part of dorsal thoracic segment of trunk property_value: skos:prefLabel "upper back muscle" xsd:string [Term] id: UBERON:0008255 name: right clavicle def: "A clavicle that is in the right side of a entire appendicular skeleton." [OBOL:automatic] xref: FMA:13322 is_a: UBERON:0001105 {source="FMA"} ! clavicle bone intersection_of: UBERON:0001105 ! clavicle bone intersection_of: BSPO:0000121 UBERON:0002091 ! appendicular skeleton relationship: BSPO:0000121 UBERON:0002091 ! appendicular skeleton [Term] id: UBERON:0008256 name: left clavicle def: "A clavicle that is in the left side of a entire appendicular skeleton." [OBOL:automatic] xref: FMA:13323 is_a: UBERON:0001105 {source="FMA"} ! clavicle bone intersection_of: UBERON:0001105 ! clavicle bone intersection_of: BSPO:0000120 UBERON:0002091 ! appendicular skeleton relationship: BSPO:0000120 UBERON:0002091 ! appendicular skeleton [Term] id: UBERON:0008266 name: periodontal ligament def: "The fibrous connective tissue that surrounds the root of a tooth, separating it from and attaching it to the alveolar bone. It extends from the base of the gingival mucosa to the fundus of the bony socket, and its main function is to hold the tooth in its socket[BTO]." [BTO:0001020, https://github.com/obophenotype/uberon/issues/1233, https://github.com/obophenotype/uberon/issues/21, Wikipedia:Periodontal_fiber] subset: pheno_slim synonym: "alveolar periosteum" RELATED [BTO:0001020] synonym: "alveolodental ligament" RELATED [BTO:0001020] synonym: "alveolodental membrane" RELATED [BTO:0001020] synonym: "desmodontium" RELATED [BTO:0001020, http://www.drugs.com/dict/desmodentium.html] synonym: "fibra periodontalis" EXACT OMO:0003011 [Wikipedia:Periodontal_ligament] synonym: "odontoperiosteum" RELATED [BTO:0001020] synonym: "paradentium" RELATED [BTO:0001020] synonym: "PDL" RELATED [Wikipedia:Periodontal_ligament] synonym: "peridental membrane" RELATED [BTO:0001020] synonym: "peridontal fiber" RELATED [http://www.drugs.com/dict/desmodentium.html] synonym: "peridontal fibre" RELATED [http://www.drugs.com/dict/desmodentium.html] synonym: "peridontal ligament" RELATED [] synonym: "peridontal ligament fiber" RELATED [http://www.drugs.com/dict/desmodentium.html] synonym: "peridontal ligament fibre" RELATED [http://www.drugs.com/dict/desmodentium.html] synonym: "peridontal membrane" RELATED [BTO:0001020] synonym: "peridontium" RELATED [BTO:0001020] synonym: "periodontal fiber" EXACT OMO:0003011 [Wikipedia:Periodontal_ligament] synonym: "periodontal fibre" EXACT OMO:0003011 [Wikipedia:Periodontal_ligament] synonym: "periodontium" RELATED INCONSISTENT [FMA:56665] xref: BTO:0001020 xref: CALOHA:TS-0763 xref: EMAPA:35679 xref: FMA:56665 xref: GAID:1259 xref: MA:0002467 xref: SCTID:245775004 xref: Wikipedia:Periodontal_fiber is_a: UBERON:0008846 {source="FMA-moved"} ! skeletal ligament is_a: UBERON:0010313 ! neural crest-derived structure intersection_of: UBERON:0000211 ! ligament intersection_of: BFO:0000050 UBERON:0001758 ! part of periodontium relationship: BFO:0000050 UBERON:0001758 {source="BTO"} ! part of periodontium relationship: RO:0002202 UBERON:0008969 {source="PMID:19767574", source="Wikipedia:Dental_follicle"} ! develops from dental follicle property_value: foaf:depiction "https://upload.wikimedia.org/wikipedia/commons/d/dc/The_Periodontium.jpg" xsd:anyURI property_value: seeAlso FMA:76870 property_value: terms:contributor https://orcid.org/0000-0002-6601-2165 property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 [Term] id: UBERON:0008281 name: tooth bud def: "A knoblike tooth primordium that develops into the mature tooth and consists of enamel organ, dental papilla, and dental sac enclosing them." [http://medical-dictionary.thefreedictionary.com/tooth+germ, UBERON:cjm] synonym: "dental bud" EXACT [FMA:306006] synonym: "dental germ" EXACT [http://medical-dictionary.thefreedictionary.com/tooth+germ] synonym: "tooth germ" EXACT [Wikipedia:Tooth_development] xref: BTO:0001838 xref: FMA:306006 xref: MESH:D014083 xref: NCIT:C34313 xref: SCTID:53301001 xref: UMLS:C0040442 {source="ncithesaurus:Tooth_Bud"} is_a: BFO:0000002 is_a: UBERON:0005423 ! developing anatomical structure relationship: RO:0002202 UBERON:0005087 ! develops from tooth placode [Term] id: UBERON:0008304 name: inner chondrogenic layer of perichondrium def: "The perichondrium consists of two separate layers: an outer fibrous layer and inner chondrogenic layer. The chondrogenic layer remains undifferentiated and can form chondroblasts or chondrocytes." [Wikipedia:The_Free_Encyclopedia] xref: BTO:0005090 xref: Wikipedia:The_Free_Encyclopedia is_a: UBERON:0002384 ! connective tissue relationship: BFO:0000050 UBERON:0002222 {source="BTO"} ! part of perichondrium relationship: RO:0002162 NCBITaxon:7742 ! in taxon Vertebrata [Term] id: UBERON:0008305 name: outer fibrous layer of perichondrium def: "The perichondrium consists of two separate layers: an outer fibrous layer and inner chondrogenic layer. The fibrous layer contains fibroblasts, which produce collagenous fibers." [Wikipedia:The_Free_Encyclopedia] xref: BTO:0005091 xref: Wikipedia:The_Free_Encyclopedia is_a: UBERON:0002384 ! connective tissue relationship: BFO:0000050 UBERON:0002222 {source="BTO"} ! part of perichondrium [Term] id: UBERON:0008307 name: heart endothelium def: "An endothelium that is part of a heart [Automatically generated definition]." [OBOL:automatic] synonym: "cardiac endothelium" RELATED [BTO:0004293] xref: BTO:0004293 is_a: UBERON:0004852 ! cardiovascular system endothelium intersection_of: UBERON:0001986 ! endothelium intersection_of: BFO:0000050 UBERON:0000948 ! part of heart relationship: BFO:0000050 UBERON:0000948 ! part of heart property_value: skos:prefLabel "heart endothelium" xsd:string [Term] id: UBERON:0008310 name: nasopharyngeal gland def: "A gland that is part of a nasopharynx." [OBOL:automatic] subset: organ_slim xref: FMA:55076 xref: SCTID:178973008 is_a: UBERON:0003295 ! pharyngeal gland intersection_of: UBERON:0002530 ! gland intersection_of: BFO:0000050 UBERON:0001728 ! part of nasopharynx relationship: BFO:0000050 UBERON:0001728 ! part of nasopharynx [Term] id: UBERON:0008324 name: erectile tissue def: "With numerous vascular spaces that may become engorged with blood." [Wikipedia:Erectile_tissue] comment: Examples: corpus cavernosum or penis or clitoris xref: Wikipedia:Erectile_tissue is_a: UBERON:0000479 ! tissue relationship: RO:0002162 NCBITaxon:33213 ! in taxon Bilateria [Term] id: UBERON:0008331 name: clitoral smooth muscle def: "A smooth muscle tissue that is part of a clitoris." [OBOL:automatic] synonym: "clitoris smooth muscle" RELATED [BTO:0005000] xref: BTO:0005000 is_a: UBERON:0001135 ! smooth muscle tissue is_a: UBERON:0005156 ! reproductive structure intersection_of: UBERON:0001135 ! smooth muscle tissue intersection_of: BFO:0000050 UBERON:0002411 ! part of clitoris relationship: BFO:0000050 UBERON:0002411 ! part of clitoris [Term] id: UBERON:0008338 name: plantar part of pes def: "The sole is the bottom of the foot." [Wikipedia:Sole_(foot)] subset: pheno_slim synonym: "pelma" RELATED [Wikipedia:Sole_(foot)] synonym: "planta" EXACT OMO:0003011 [FMA:TA] synonym: "planta" RELATED OMO:0003011 [Wikipedia:Sole_(foot)] synonym: "plantar part of foot" EXACT [FMA:25000] synonym: "plantar region" EXACT [FMA:25000] synonym: "regio plantaris" EXACT OMO:0003011 [FMA:TA] synonym: "sole" EXACT [FMA:25000] synonym: "sole of foot" EXACT [FMA:25000] synonym: "sole of foot" RELATED [Wikipedia:Sole_(foot)] synonym: "sole of the foot" RELATED [Wikipedia:Sole_(foot)] synonym: "soles of the feet" RELATED [Wikipedia:Sole_(foot)] xref: BTO:0005078 xref: CALOHA:TS-0379 xref: FMA:25000 xref: galen:SoleOfFoot xref: NCIT:C33326 xref: SCTID:57999000 xref: UMLS:C0230463 {source="ncithesaurus:Plantar_Region"} xref: Wikipedia:Sole_(foot) is_a: UBERON:0005445 {source="FMA"} ! segment of pes is_a: UBERON:0008837 ! palmar/plantar part of autopod intersection_of: UBERON:0008837 ! palmar/plantar part of autopod intersection_of: BFO:0000050 UBERON:0002387 ! part of pes property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/4/41/Soles2.jpg" xsd:anyURI [Term] id: UBERON:0008339 name: microvascular endothelium xref: BTO:0003122 is_a: UBERON:0004638 ! blood vessel endothelium intersection_of: UBERON:0001986 ! endothelium intersection_of: BFO:0000050 UBERON:8410081 ! part of blood microvessel relationship: BFO:0000050 UBERON:8410081 ! part of blood microvessel property_value: seeAlso "https://github.com/obophenotype/uberon/issues/2186" xsd:string property_value: skos:prefLabel "microvascular endothelium" xsd:string [Term] id: UBERON:0008342 name: intestinal villus of duodenum def: "An intestinal villus in the duodenum." [OBOL:automatic] xref: FMA:63300 is_a: UBERON:0001213 ! intestinal villus intersection_of: UBERON:0001213 ! intestinal villus intersection_of: BFO:0000050 UBERON:0002114 ! part of duodenum relationship: BFO:0000050 UBERON:0000320 ! part of duodenal mucosa property_value: skos:prefLabel "intestinal villus of duodenum" xsd:string [Term] id: UBERON:0008343 name: intestinal villus of jejunum def: "An intestinal villus in the jejunum." [OBOL:automatic] xref: FMA:63301 is_a: UBERON:0001213 ! intestinal villus intersection_of: UBERON:0001213 ! intestinal villus intersection_of: BFO:0000050 UBERON:0002115 ! part of jejunum relationship: BFO:0000050 UBERON:0000399 ! part of jejunal mucosa [Term] id: UBERON:0008344 name: intestinal villus of ileum def: "An intestinal villus in the ileum." [OBOL:automatic] xref: FMA:63302 is_a: UBERON:0001213 ! intestinal villus intersection_of: UBERON:0001213 ! intestinal villus intersection_of: BFO:0000050 UBERON:0002116 ! part of ileum relationship: BFO:0000050 UBERON:0000331 ! part of ileal mucosa [Term] id: UBERON:0008345 name: ileal epithelium def: "An epithelium that is part of a ileum." [OBOL:automatic] subset: human_reference_atlas synonym: "epithelium of ileum" EXACT [FMA:17233] xref: EMAPA:35423 xref: FMA:17233 xref: MA:0003217 xref: SCTID:47046000 is_a: UBERON:0013636 ! epithelium of intestinal villus intersection_of: UBERON:0000483 ! epithelium intersection_of: BFO:0000050 UBERON:0002116 ! part of ileum relationship: BFO:0000050 UBERON:0008344 {source="FMA"} ! part of intestinal villus of ileum property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0008346 name: duodenal epithelium def: "An epithelium that is part of a duodenum." [OBOL:automatic] subset: human_reference_atlas synonym: "epithelium of duodenum" EXACT [FMA:17231] xref: CALOHA:TS-2087 xref: EMAPA:19078 xref: FMA:17231 xref: MA:0003208 xref: SCTID:66036002 is_a: UBERON:0013636 ! epithelium of intestinal villus intersection_of: UBERON:0000483 ! epithelium intersection_of: BFO:0000050 UBERON:0002114 ! part of duodenum relationship: BFO:0000050 UBERON:0008342 {source="FMA"} ! part of intestinal villus of duodenum property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "duodenal epithelium" xsd:string [Term] id: UBERON:0008367 name: breast epithelium def: "An epithelium that is part of a breast." [OBOL:automatic] xref: BTO:0001428 is_a: UBERON:0000483 ! epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: BFO:0000050 UBERON:0000310 ! part of breast relationship: BFO:0000050 UBERON:0000310 ! part of breast [Term] id: UBERON:0008397 name: tracheobronchial epithelium def: "Epithelium pertaining to the trachea and bronchi." [Dorlands_Medical_Dictionary:MerckMedicus] synonym: "bronchotracheal epithelium" RELATED [BTO:0002925] xref: BTO:0002925 xref: CALOHA:TS-1063 is_a: UBERON:0004815 ! lower respiratory tract epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: BFO:0000050 UBERON:0007196 ! part of tracheobronchial tree relationship: BFO:0000050 UBERON:0007196 ! part of tracheobronchial tree property_value: skos:prefLabel "tracheobronchial epithelium" xsd:string [Term] id: UBERON:0008404 name: proximal tubular epithelium def: "The cells lining the proximal tubule are cuboidal epithelial cells with deep basal membrane invaginations that provide a large basal surface area. The long microvilli (the brush border) lining the tubule lumen, maximize luminal surface area and make these cells ideally suited for both reabsorptive and secretory functions." [_Chapter_3, Renal_Physiology:Section_7] synonym: "epithelium of proximal convoluted tubule" EXACT [FMA:64808] synonym: "epithelium of proximal renal tubule" EXACT [FMA:64808] synonym: "proximal renal tubule epithelium" EXACT [FMA:64808] synonym: "proximal tubule epithelium" RELATED [BTO:0003576] synonym: "proximale tubular epithelium" EXACT [BTO:0003576] xref: BTO:0003576 xref: FMA:64808 is_a: UBERON:0004810 ! nephron tubule epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: BFO:0000050 UBERON:0004134 ! part of proximal tubule intersection_of: RO:0002220 UBERON:0000464 ! adjacent to anatomical space relationship: BFO:0000050 UBERON:0004134 ! part of proximal tubule property_value: IAO:0000116 "See https://github.com/obophenotype/uberon/issues/1305" xsd:string [Term] id: UBERON:0008408 name: distal tubular epithelium def: "An epithelium that is part of a distal tubule." [OBOL:automatic] synonym: "distal tubule epithelium" RELATED [BTO:0003948] xref: BTO:0003948 is_a: UBERON:0004810 ! nephron tubule epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: BFO:0000050 UBERON:0004135 ! part of distal tubule intersection_of: RO:0002220 UBERON:0000464 ! adjacent to anatomical space relationship: BFO:0000050 UBERON:0004135 {source="BTO"} ! part of distal tubule property_value: IAO:0000116 "See https://github.com/obophenotype/uberon/issues/1305" xsd:string [Term] id: UBERON:0008425 name: mammary ridge def: "A ridge of epidermal cells that will form the mammary placodes." [GOC:dph] synonym: "mammary fold" EXACT [http://dictionary.reference.com/browse/mammary+ridge] synonym: "mammary gland ridge" EXACT [EMAPA:18541] synonym: "mammary line" RELATED [Wikipedia:Milk_line] synonym: "milk line" RELATED [Wikipedia:Milk_line] xref: EMAPA:18541 xref: Wikipedia:Milk_line is_a: BFO:0000002 is_a: UBERON:0006598 ! presumptive structure relationship: BFO:0000050 UBERON:0002100 ! part of trunk relationship: RO:0002202 UBERON:0000924 ! develops from ectoderm relationship: RO:0002387 UBERON:0001911 ! has potential to develop into mammary gland property_value: IAO:0000116 "consider splitting ridge (precursor) and milk line" xsd:string [Term] id: UBERON:0008429 name: cervical vertebral foramen def: "A vertebral foramen that is part of a cervical vertebra." [OBOL:automatic] xref: FMA:13480 xref: SCTID:280833008 is_a: UBERON:0001131 ! vertebral foramen is_a: UBERON:0005744 ! bone foramen intersection_of: UBERON:0001131 ! vertebral foramen intersection_of: BFO:0000050 UBERON:0002413 ! part of cervical vertebra relationship: BFO:0000050 UBERON:0002413 ! part of cervical vertebra [Term] id: UBERON:0008430 name: lumbar vertebral foramen def: "A vertebral foramen that is part of a lumbar vertebra." [OBOL:automatic] xref: FMA:24826 xref: SCTID:280835001 is_a: UBERON:0001131 ! vertebral foramen is_a: UBERON:0005744 ! bone foramen intersection_of: UBERON:0001131 ! vertebral foramen intersection_of: BFO:0000050 UBERON:0002414 ! part of lumbar vertebra relationship: BFO:0000050 UBERON:0002414 ! part of lumbar vertebra [Term] id: UBERON:0008431 name: sacral foramen def: "A vertebral foramen that is part of a sacral vertebra." [OBOL:automatic] xref: FMA:31749 is_a: UBERON:0001131 ! vertebral foramen is_a: UBERON:0005744 ! bone foramen intersection_of: UBERON:0001131 ! vertebral foramen intersection_of: BFO:0000050 UBERON:0001094 ! part of sacral vertebra relationship: BFO:0000050 UBERON:0001094 ! part of sacral vertebra [Term] id: UBERON:0008432 name: thoracic vertebral foramen def: "A vertebral foramen that is part of a thoracic vertebra." [OBOL:automatic] xref: FMA:9143 xref: SCTID:280834002 is_a: UBERON:0001131 ! vertebral foramen is_a: UBERON:0005744 ! bone foramen intersection_of: UBERON:0001131 ! vertebral foramen intersection_of: BFO:0000050 UBERON:0002347 ! part of thoracic vertebra relationship: BFO:0000050 UBERON:0002347 ! part of thoracic vertebra [Term] id: UBERON:0008433 name: lumbar vertebral arch def: "A neural arch that is part of a lumbar vertebra." [OBOL:automatic] synonym: "arch of lumbar vertebra" EXACT [FMA:16076] xref: FMA:16076 xref: SCTID:312766000 is_a: UBERON:0003828 ! abdominal segment bone is_a: UBERON:0003861 ! neural arch is_a: UBERON:0004247 ! bone of dorsum intersection_of: UBERON:0003861 ! neural arch intersection_of: BFO:0000050 UBERON:0002414 ! part of lumbar vertebra relationship: BFO:0000050 UBERON:0002414 ! part of lumbar vertebra [Term] id: UBERON:0008434 name: cervical vertebral arch def: "A neural arch that is part of a cervical vertebra." [OBOL:automatic] synonym: "arch of cervical vertebra" EXACT [FMA:23893] xref: FMA:23893 xref: SCTID:165269004 is_a: UBERON:0003458 ! neck bone is_a: UBERON:0003861 ! neural arch is_a: UBERON:0004247 ! bone of dorsum intersection_of: UBERON:0003861 ! neural arch intersection_of: BFO:0000050 UBERON:0002413 ! part of cervical vertebra relationship: BFO:0000050 UBERON:0002413 ! part of cervical vertebra [Term] id: UBERON:0008435 name: vertebral arch of sacral segment def: "A neural arch that is part of a sacral vertebra." [OBOL:automatic] xref: FMA:32401 is_a: UBERON:0003828 ! abdominal segment bone is_a: UBERON:0003861 ! neural arch is_a: UBERON:0004247 ! bone of dorsum is_a: UBERON:0005179 ! pelvic region element intersection_of: UBERON:0003861 ! neural arch intersection_of: BFO:0000050 UBERON:0001094 ! part of sacral vertebra relationship: BFO:0000050 UBERON:0001094 ! part of sacral vertebra [Term] id: UBERON:0008436 name: thoracic vertebral arch def: "A neural arch that is part of a thoracic vertebra." [OBOL:automatic] synonym: "arch of thoracic vertebra" EXACT [FMA:9151] xref: FMA:9151 xref: SCTID:312764002 is_a: UBERON:0003827 ! thoracic segment bone is_a: UBERON:0003861 ! neural arch is_a: UBERON:0004247 ! bone of dorsum intersection_of: UBERON:0003861 ! neural arch intersection_of: BFO:0000050 UBERON:0002347 ! part of thoracic vertebra relationship: BFO:0000050 UBERON:0002347 ! part of thoracic vertebra [Term] id: UBERON:0008447 name: intertarsal joint def: "Intertarsal articulations are the joints of the tarsus. The specific intertarsal articulations are: Talocalcaneal articulation Talocalcaneonavicular articulation Calcaneocuboid articulation Cuneonavicular articulation Cuboideonavicular articulation Intercuneiform articulation Cuneocuboid articulation." [Wikipedia:Intertarsal_articulations] synonym: "articulationes intertarsale" RELATED [MESH:A02.835.583.378.831] synonym: "articulationes intertarsales" RELATED OMO:0003011 [Wikipedia:Intertarsal_articulations] synonym: "articulationes intertarseae" RELATED [MESH:A02.835.583.378.831] synonym: "intermetatarsal joint" RELATED [MESH:A02.835.583.378.831] synonym: "intertarsal" RELATED [Wikipedia:Intertarsal_articulations] synonym: "intertarsal articulation" RELATED [Wikipedia:Intertarsal_articulations] synonym: "intertarsal joint" RELATED [MESH:A02.835.583.378.831] synonym: "tarsal joint" RELATED [MESH:A02.835.583.378.831] synonym: "tarsal joints" RELATED [Wikipedia:Intertarsal_articulations] xref: EMAPA:37762 {source="MA:th"} xref: FMA:44281 xref: GAID:259 xref: MA:0003112 xref: MESH:D013640 xref: NCIT:C33735 xref: SCTID:182221001 xref: SCTID:361283005 xref: UMLS:C1527245 {source="ncithesaurus:Tarsal_Joint"} xref: Wikipedia:Intertarsal_articulations is_a: UBERON:0001487 ! pes joint intersection_of: UBERON:0000982 ! skeletal joint intersection_of: RO:0002176 UBERON:0001447 {cardinality="2"} ! connects tarsal bone relationship: BFO:0000050 UBERON:0004454 ! part of tarsal region relationship: RO:0002176 UBERON:0001447 ! connects tarsal bone property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/5/5f/Gray360.png" xsd:anyURI [Term] id: UBERON:0008522 name: nasal muscle def: "Any muscle organ that is part of an nose." [OBOL:automatic] synonym: "muscle of nose" EXACT [OBOL:automatic] xref: FMA:73758 xref: NCIT:C33158 xref: SCTID:244730009 xref: UMLS:C0224219 {source="ncithesaurus:Nasal_Muscle"} is_a: UBERON:0001577 {source="FMA"} ! facial muscle intersection_of: UBERON:0001630 ! muscle organ intersection_of: BFO:0000050 UBERON:0000004 ! part of nose relationship: BFO:0000050 UBERON:0000004 ! part of nose [Term] id: UBERON:0008713 name: pectoral girdle and thoracic body wall skeletal muscle xref: EHDAA2:0001421 xref: EMAPA:17748 xref: RETIRED_EHDAA2:0001422 is_a: UBERON:0001134 ! skeletal muscle tissue [Term] id: UBERON:0008715 name: muscle tissue of prostate def: "A muscle tissue that is part of a prostate gland." [OBOL:automatic] synonym: "prostate gland muscle tissue" EXACT [OBOL:automatic] synonym: "prostate muscle tissue" EXACT [OBOL:automatic] synonym: "prostatic muscle" EXACT [] synonym: "prostatic musclular tissue" EXACT [] xref: NCIT:C13100 xref: SCTID:251498008 xref: UMLS:C1183911 {source="ncithesaurus:Prostatic_Muscular_Tissue"} is_a: UBERON:0002385 ! muscle tissue is_a: UBERON:0005156 ! reproductive structure intersection_of: UBERON:0002385 ! muscle tissue intersection_of: BFO:0000050 UBERON:0002367 ! part of prostate gland relationship: BFO:0000050 UBERON:0002367 ! part of prostate gland [Term] id: UBERON:0008772 name: proximal epiphysis of tibia def: "A proximal epiphysis that is part of a tibia." [OBOL:automatic] subset: pheno_slim synonym: "head of tibia" EXACT [FMA:33113] synonym: "proximal end of tibia" EXACT [FMA:33113] synonym: "proximal tibial epiphysis" EXACT [] synonym: "upper end of tibia" EXACT [FMA:33113] xref: FMA:33113 xref: NCIT:C32722 xref: SCTID:302526005 xref: UMLS:C0932431 {source="ncithesaurus:Head_of_the_Tibia"} xref: Wikipedia:Upper_extremity_of_tibia is_a: UBERON:0004380 ! proximal epiphysis is_a: UBERON:0004383 ! epiphysis of tibia intersection_of: UBERON:0004380 ! proximal epiphysis intersection_of: BFO:0000050 UBERON:0000979 ! part of tibia [Term] id: UBERON:0008775 name: proximal epiphysis of fibula def: "A proximal epiphysis that is part of a fibula." [OBOL:automatic] subset: pheno_slim synonym: "caput fibulae" EXACT OMO:0003011 [Wikipedia:Head_of_fibula] synonym: "fibular head" RELATED [FMA:33729] synonym: "head of fibula" EXACT [FMA:33729] synonym: "proximal end of fibula" EXACT [FMA:33729] synonym: "upper end of fibula" EXACT [FMA:33729] xref: EMAPA:37890 {source="MA:th"} xref: FMA:33729 xref: galen:HeadOfFibula xref: NCIT:C32719 xref: SCTID:182080006 xref: UMLS:C0223908 {source="ncithesaurus:Head_of_the_Fibula"} xref: Wikipedia:Head_of_fibula is_a: UBERON:0004380 ! proximal epiphysis is_a: UBERON:0004388 ! epiphysis of fibula intersection_of: UBERON:0004380 ! proximal epiphysis intersection_of: BFO:0000050 UBERON:0001446 ! part of fibula [Term] id: UBERON:0008780 name: inner cell mass derived epiblast def: "An embryonic structure that is derived from the inner cell mass and lies above the hypoblast and gives rise to the three primary germ layers." [MP:0003886] comment: The epiblast cells (appearing on day 8 of human embryonic development) make up a columnar epithelium with dense microvilli on the apical surface. During gastrulation, the epiblast cells undergo epithelial-to-mesenchymal transition and delaminate to become the loose mesenchyme of the primitive streak. The epiblast is present in postimplantation mouse embryos between E5.5-E7.5. subset: early_development subset: pheno_slim synonym: "embryonic epiblast" RELATED [MP:0003886] xref: EHDAA2:0000444 xref: EHDAA:42 xref: EHDAA:75 xref: EMAPA:16050 xref: NCIT:C34164 xref: UMLS:C1516906 {source="ncithesaurus:Epiblast"} is_a: BFO:0000002 is_a: UBERON:0002532 ! epiblast (generic) intersection_of: UBERON:0002532 ! epiblast (generic) intersection_of: RO:0002202 UBERON:0000087 ! develops from inner cell mass relationship: BFO:0000050 UBERON:0000091 ! part of bilaminar disc relationship: RO:0002202 UBERON:0000087 {source="Wikipedia"} ! develops from inner cell mass property_value: skos:prefLabel "inner cell mass derived epiblast" xsd:string [Term] id: UBERON:0008783 name: dorsal venous arch def: "The dorsal venous arch of the foot is a superficial vein that connects the small saphenous vein and the great saphenous vein. Anatomically, it is defined by where the dorsal veins of the first and fifth digit, respectively, meet the great saphenous vein and small saphenous vein." [Wikipedia:Dorsal_venous_arch_of_the_foot] subset: human_reference_atlas synonym: "arcus venosus dorsalis pedis" EXACT [Wikipedia:Dorsal_venous_arch_of_the_foot] synonym: "arcus venosus dorsalis pedis" RELATED OMO:0003011 [Wikipedia:Dorsal_venous_arch_of_the_foot] synonym: "dorsal venous arch of foot" EXACT [FMA:44356] xref: EMAPA:37521 {source="MA:th"} xref: FMA:44356 xref: MA:0002110 xref: SCTID:231189006 xref: Wikipedia:Dorsal_venous_arch_of_the_foot is_a: UBERON:0001638 {source="MA"} ! vein relationship: RO:0002170 UBERON:0001545 ! connected to anterior tibial vein relationship: RO:0002170 UBERON:0001547 ! connected to small saphenous vein relationship: RO:0002170 UBERON:0001550 ! connected to medial marginal vein property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/4/4e/Gray581.png" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0008784 name: lower limb segment def: "A limb segment that is part of a hindlimb." [OBOL:automatic] synonym: "free lower limb segment" EXACT [FMA:24877] synonym: "free lower limb subdivision" EXACT [FMA:24877] synonym: "segment of free lower limb" EXACT [FMA:24877] synonym: "subdivision of free lower limb" EXACT [FMA:24877] xref: FMA:24877 is_a: UBERON:0002529 ! limb segment intersection_of: UBERON:0002529 ! limb segment intersection_of: BFO:0000050 UBERON:0002103 ! part of hindlimb relationship: BFO:0000050 UBERON:0002103 ! part of hindlimb [Term] id: UBERON:0008785 name: upper limb segment def: "A limb segment that is part of a forelimb." [OBOL:automatic] synonym: "free upper limb segment" EXACT [FMA:24876] synonym: "free upper limb subdivision" EXACT [FMA:24876] synonym: "segment of free upper limb" EXACT [FMA:24876] synonym: "subdivision of free upper limb" EXACT [FMA:24876] xref: FMA:24876 is_a: UBERON:0002529 ! limb segment intersection_of: UBERON:0002529 ! limb segment intersection_of: BFO:0000050 UBERON:0002102 ! part of forelimb relationship: BFO:0000050 UBERON:0002102 ! part of forelimb [Term] id: UBERON:0008789 name: cranial fossa def: "Any of the three large depressions in the posterior, middle, and anterior aspects of the floor of the cranial cavity." [http://mw1.merriam-webster.com/medical/cranial%20fossa] xref: FMA:321144 is_a: UBERON:0004704 ! bone fossa intersection_of: UBERON:0004704 ! bone fossa intersection_of: BFO:0000050 UBERON:0003128 ! part of cranium relationship: BFO:0000050 UBERON:0004766 {is_inferred="true", source="https://github.com/obophenotype/uberon/wiki/Inferring-part-of-relationships"} ! part of cranial bone property_value: IAO:0000116 "todo - review the relationships for this and its subclasses; the relation should be bounded rather than part of, and contains should be used for the brain parts contained by the fossae" xsd:string [Term] id: UBERON:0008801 name: parotid gland primordium xref: EHDAA2:0001413 xref: EHDAA:9246 is_a: UBERON:0001048 {source="Obol"} ! primordium [Term] id: UBERON:0008803 name: skin of cheek def: "A zone of skin that is part of a cheek." [OBOL:automatic] subset: pheno_slim synonym: "cheek skin" EXACT [FMA:24759] xref: FMA:24759 xref: SCTID:181472009 is_a: UBERON:1000021 ! skin of face intersection_of: UBERON:0000014 ! zone of skin intersection_of: BFO:0000050 UBERON:0001567 ! part of cheek relationship: BFO:0000050 UBERON:0001567 ! part of cheek [Term] id: UBERON:0008805 name: gingival groove def: "The gingival sulcus is an area of potential space between a tooth and the surrounding gingival tissue and is lined by sulcular epithelium. The depth of the sulcus (Latin for groove) is bounded by two entities: apically by the gingival fibers of the connective tissue attachment and coronally by the free gingival margin." [Wikipedia:Gingival_sulcus] synonym: "gingival sulcus" EXACT [FMA:74580] synonym: "sulcus gingivalis" EXACT OMO:0003011 [FMA:TA] synonym: "sulcus gingivalis" RELATED OMO:0003011 [Wikipedia:Gingival_sulcus] synonym: "tooth-gingiva interface" EXACT [] xref: FMA:74580 xref: NCIT:C114645 xref: SCTID:245753001 xref: Wikipedia:Gingival_sulcus is_a: UBERON:0000093 ! sulcus intersection_of: UBERON:0000093 ! sulcus intersection_of: RO:0002220 UBERON:0001091 ! adjacent to calcareous tooth intersection_of: RO:0002220 UBERON:0001828 ! adjacent to gingiva relationship: BFO:0000050 UBERON:0000165 ! part of mouth relationship: RO:0002162 NCBITaxon:7742 ! in taxon Vertebrata relationship: RO:0002220 UBERON:0001091 ! adjacent to calcareous tooth relationship: RO:0002220 UBERON:0001828 ! adjacent to gingiva property_value: foaf:depiction "https://upload.wikimedia.org/wikipedia/commons/5/5e/Gingival_sulcus.PNG" xsd:anyURI [Term] id: UBERON:0008811 name: intromittent organ def: "An external organ of a male organism that is specialized to deliver sperm during copulation. Intromittent organs are found most often in terrestrial species, as most aquatic species fertilize their eggs externally, although there are exceptions[WP]." [Wikipedia:Intromittent_organ] subset: grouping_class subset: organ_slim synonym: "aedeagus" NARROW SENSU [FBbt:00004850] synonym: "copulatory organ" RELATED [] synonym: "penis" NARROW [] xref: AAO:0010255 xref: FBbt:00004850 {sssom:mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"} xref: HAO:0000091 xref: TAO:0002036 xref: TGMA:0000585 xref: Wikipedia:Intromittent_organ is_a: UBERON:0003135 ! male reproductive organ relationship: RO:0002162 NCBITaxon:6072 ! in taxon Eumetazoa relationship: RO:0002216 GO:0007620 ! capable of part of copulation [Term] id: UBERON:0008814 name: pharyngeal arch system def: "A transient embryonic complex that comprises the pharyngeal arches, bulges of tissues of mesoderm and neural crest derivation through which pass nerves and pharyngeal arch arteries. The arches are separated internally by pharyngeal pouches, evaginations of foregut endoderm, and externally by pharyngeal clefts, invaginations of surface ectoderm. The development of the system ends when the stucture it contributes to are forming, which may include (depending on species) the thymus, thyroid, parathyroids, maxilla, mandible, aortic arch, cardiac outflow tract, external and middle ear[GO,modified]." [GO:0060037, GOC:dph] synonym: "embryonic pharyngeal complex" EXACT [] synonym: "pharyngeal apparatus" EXACT [] synonym: "pharyngeal arch complex" RELATED [] synonym: "pharyngeal arch region" RELATED [EHDAA2:0000187] synonym: "pharyngeal arches and clefts" RELATED [] synonym: "pharyngeal complex" RELATED [] synonym: "pharyngeal system" EXACT [GO:0060037] xref: EHDAA2:0000187 xref: FMA:293041 xref: NCIT:C34248 xref: UMLS:C1519038 {source="ncithesaurus:Pharyngeal_Apparatus"} is_a: UBERON:0034921 ! multi organ part structure relationship: BFO:0000050 UBERON:0000922 ! part of embryo relationship: BFO:0000050 UBERON:0009145 ! part of pharyngeal region of foregut relationship: RO:0002162 NCBITaxon:7711 ! in taxon Chordata property_value: IAO:0000116 "Currently defined in a vertebrate specific manner. The arch system has origins in basal deuterostomes, consider generalizing" xsd:string property_value: skos:prefLabel "pharyngeal arch system" xsd:string [Term] id: UBERON:0008816 name: embryonic head def: "A head that is part of a embryo." [OBOL:automatic] subset: non_informative xref: CALOHA:TS-0246 xref: FBbt:00000155 {sssom:mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"} xref: FMA:293011 is_a: UBERON:0000033 ! head intersection_of: UBERON:0000033 ! head intersection_of: BFO:0000050 UBERON:0000922 ! part of embryo relationship: BFO:0000050 UBERON:0000922 ! part of embryo property_value: skos:prefLabel "embryonic head" xsd:string [Term] id: UBERON:0008817 name: thymus primordium endoderm def: "An endoderm that is part of a thymus primordium." [OBOL:automatic] is_a: UBERON:0000925 ! endoderm intersection_of: UBERON:0000925 ! endoderm intersection_of: BFO:0000050 UBERON:0005562 ! part of thymus primordium relationship: BFO:0000050 UBERON:0005562 ! part of thymus primordium relationship: RO:0002254 UBERON:0007124 {source="PMID:16313389"} ! has developmental contribution from pharyngeal pouch 3 [Term] id: UBERON:0008823 name: neural tube derived brain def: "A brain that develops_from a neural tube." [https://github.com/obophenotype/uberon/issues/338, OBOL:automatic] synonym: "vertebrate brain" NARROW [] is_a: UBERON:0000489 {source="ZFA"} ! cavitated compound organ is_a: UBERON:0000955 ! brain intersection_of: UBERON:0000955 ! brain intersection_of: RO:0002202 UBERON:0001049 ! develops from neural tube relationship: BFO:0000050 UBERON:0000033 {source="FMA"} ! part of head relationship: RO:0002202 UBERON:0001049 ! develops from neural tube property_value: IAO:0000116 "a reasoner should automatically classify all the vertebrate ontology brain classes here" xsd:string property_value: seeAlso "https://github.com/obophenotype/uberon/issues/338" xsd:anyURI property_value: skos:prefLabel "neural tube derived brain" xsd:string [Term] id: UBERON:0008824 name: duct of epididymis def: "Any duct branching of of the main epididymis duct." [http://orcid.org/0000-0002-6601-2165] synonym: "epididymal duct" EXACT [MA:0001735] synonym: "epididymis duct" EXACT [FMA:18297] xref: EMAPA:36525 xref: FMA:18297 xref: MA:0001735 xref: NCIT:C32484 xref: SCTID:279623004 xref: UMLS:C0458632 {source="ncithesaurus:Duct_of_the_Epididymis"} is_a: UBERON:0005904 ! duct of male reproductive system intersection_of: UBERON:0000058 ! duct intersection_of: RO:0002380 UBERON:0001301 ! branching part of epididymis relationship: RO:0002380 UBERON:0001301 ! branching part of epididymis [Term] id: UBERON:0008826 name: pulmonary surfactant def: "A substance formed by type II alveolar cells composed of surface-active lipoprotein complex (phospholipoprotein)." [Wikipedia:Pulmonary_surfactant] subset: pheno_slim synonym: "alveolar surfactant" EXACT [FMA:62780] synonym: "lung surfactant" EXACT [MA:0002534] synonym: "type II pneumocyte secretion" EXACT [] xref: EMAPA:36551 xref: FMA:62780 xref: MA:0002534 xref: NCIT:C13273 xref: UMLS:C0034085 {source="ncithesaurus:Lung_Surfactant"} xref: Wikipedia:Pulmonary_surfactant is_a: UBERON:0006538 ! respiratory system fluid/secretion intersection_of: UBERON:0006538 ! respiratory system fluid/secretion intersection_of: RO:0003001 CL:0002063 ! produced by pulmonary alveolar type 2 cell relationship: BFO:0000051 CHEBI:6495 ! has part relationship: RO:0003001 CL:0002063 ! produced by pulmonary alveolar type 2 cell [Term] id: UBERON:0008835 name: hepatic diverticulum def: "An out-pocket of thickened ventral foregut epithelium adjacent to the developing heart. Constitutes the first morphological sign of the embryonic liver. The anterior portion of the hepatic diverticulum gives rise to the liver and intrahepatic biliary tree, while the posterior portion forms the gall bladder and extrahepatic bile ducts." [http://www.stembook.org/node/512, MP:MP] subset: pheno_slim synonym: "diverticulum hepaticum" RELATED OMO:0003011 [Wikipedia:Hepatic_diverticulum] synonym: "liver diverticulum" EXACT [XAO:0000101] xref: AAO:0011057 xref: EHDAA2:0000740 xref: EHDAA:1530 xref: NCIT:C34187 xref: UMLS:C1512407 {source="ncithesaurus:Hepatic_Diverticulum"} xref: Wikipedia:Hepatic_diverticulum xref: XAO:0000101 is_a: UBERON:0004185 ! endodermal part of digestive tract is_a: UBERON:0005291 ! embryonic tissue is_a: UBERON:0007499 {source="EHDAA2"} ! epithelial sac is_a: UBERON:0009497 ! epithelium of foregut-midgut junction is_a: UBERON:0009854 ! digestive tract diverticulum relationship: BFO:0000050 UBERON:0004161 ! part of septum transversum relationship: RO:0002202 UBERON:0003894 {source="EHDAA2"} ! develops from liver primordium property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/4/4f/Gray1088.png" xsd:anyURI property_value: skos:prefLabel "hepatic diverticulum" xsd:string [Term] id: UBERON:0008836 name: liver bud xref: BTO:0001642 is_a: UBERON:0004185 ! endodermal part of digestive tract is_a: UBERON:0007499 {source="cjm"} ! epithelial sac is_a: UBERON:0009497 ! epithelium of foregut-midgut junction is_a: UBERON:0009854 ! digestive tract diverticulum relationship: RO:0002202 UBERON:0008835 {source="http://www.stembook.org/node/512"} ! develops from hepatic diverticulum property_value: skos:prefLabel "liver bud" xsd:string [Term] id: UBERON:0008837 name: palmar/plantar part of autopod is_a: UBERON:0002529 ! limb segment relationship: BFO:0000050 UBERON:0002470 ! part of autopod region [Term] id: UBERON:0008845 name: nonskeletal ligament def: "A ligament that does not connect two skeletal elements." [http://orcid.org/0000-0002-6601-2165] synonym: "fibrous ligament" RELATED [Wikipedia:Ligament] synonym: "non-skeletal ligament" EXACT [] xref: FMA:25625 xref: MA:0003004 xref: SCTID:410746001 is_a: UBERON:0000211 {source="cjm"} ! ligament disjoint_from: UBERON:0008846 ! skeletal ligament [Term] id: UBERON:0008846 name: skeletal ligament def: "Dense regular connective tissue connecting two or more adjacent skeletal elements[VSAO,modified]." [GO_REF:0000034, http://dx.plos.org/10.1371/journal.pone.0051070, http://orcid.org/0000-0002-6601-2165] synonym: "articular larua" EXACT [Wikipedia:Ligament] synonym: "articular ligament" EXACT [Wikipedia:Ligament] synonym: "ligament" BROAD [VSAO:0000072, ZFA:0001675] synonym: "true ligament" EXACT [Wikipedia:Ligament] xref: AAO:0010444 xref: AEO:0000090 xref: CALOHA:TS-2146 xref: EHDAA2:0003232 xref: EV:0100144 xref: FMA:25624 xref: GAID:118 xref: MA:0003005 xref: SCTID:410744003 xref: VSAO:0000072 xref: Wikipedia:Ligament#Articular_ligaments is_a: BFO:0000002 is_a: UBERON:0000211 ! ligament intersection_of: UBERON:0000211 ! ligament intersection_of: BFO:0000050 UBERON:0001434 ! part of skeletal system intersection_of: RO:0002176 UBERON:0004765 ! connects skeletal element relationship: BFO:0000050 UBERON:0001434 ! part of skeletal system relationship: BFO:0000051 CL:0000327 {source="AEO"} ! has part extracellular matrix secreting cell relationship: RO:0002176 UBERON:0004765 ! connects skeletal element relationship: RO:0002473 UBERON:0007846 {source="VSAO"} ! composed primarily of dense regular connective tissue property_value: foaf:depiction "https://upload.wikimedia.org/wikipedia/commons/9/9a/Knee_diagram.svg" xsd:anyURI property_value: IAO:0000116 "logical definition deliberately made strict to avoid classifying MA:spiral ligament as both nonskeletal and skeletal. see https://github.com/obophenotype/mouse-anatomy-ontology/issues/71" xsd:string [Term] id: UBERON:0008851 name: ectoplacental cavity def: "Closed space within the ectoplacental cone, formed by the fusion of the parts of the amniotic fold that separate it from the amniotic cavity[MP]. a developmental cavity that exists in some mammals and is derived by division of the proamniotic space; it is further removed from the embryo than the amniotic cavity in some mammals." [http://www.medilexicon.com/medicaldictionary.php?s=epamniotic+cavity, MP:0011207] subset: pheno_slim synonym: "epamniotic cavity" EXACT [http://www.medilexicon.com/medicaldictionary.php?s=epamniotic+cavity] synonym: "epamniotic cavity" RELATED [MP:0011207] xref: EMAPA:16080 is_a: UBERON:0000464 ! anatomical space intersection_of: UBERON:0000464 ! anatomical space intersection_of: RO:0002572 UBERON:0004364 ! luminal space of ectoplacental cone relationship: RO:0002572 UBERON:0004364 ! luminal space of ectoplacental cone [Term] id: UBERON:0008856 name: stomach muscularis externa def: "The smooth muscle layer of the stomach wall that functions to churn and mix food and gastric secretions as well as to move food along the digestive tract to the intestines." [MP:0010779] subset: pheno_slim synonym: "gastric muscularis" EXACT [FMA:14909] synonym: "muscle layer of stomach" EXACT [FMA:14909] synonym: "muscularis externa of stomach" EXACT [FMA:14909] synonym: "tunica muscularis (gaster)" EXACT [FMA:14909] synonym: "tunica muscularis gastris" EXACT [] xref: FMA:14909 xref: SCTID:362132003 is_a: UBERON:0018261 ! muscular coat of digestive tract is_a: UBERON:0034933 ! layer of smooth muscle tissue intersection_of: UBERON:0006660 ! muscular coat intersection_of: BFO:0000050 UBERON:0001167 ! part of wall of stomach relationship: BFO:0000050 UBERON:0004222 {source="MA-abduced"} ! part of stomach smooth muscle relationship: RO:0002433 UBERON:0001135 ! contributes to morphology of smooth muscle tissue relationship: RO:0002433 UBERON:0001167 ! contributes to morphology of wall of stomach property_value: skos:prefLabel "stomach muscularis externa" xsd:string [Term] id: UBERON:0008857 name: stomach smooth muscle circular layer def: "The middle layer of the muscularis; it is continuous with the circular layer of the esophagus, but is absent in the fundus and lies concentric to the longitudinal axis of the stomach; the circular layer is normally tonically constricted forming a functional pyloric sphincter, which controls the movement of chyme into the duodenum." [MP:0010780] subset: pheno_slim synonym: "circular layer of gastric muscularis" EXACT [FMA:14911] synonym: "circular muscle layer of stomach" EXACT [FMA:14911] synonym: "middle circular muscle layer of stomach" EXACT [] synonym: "stratum circulare (tunica muscularis)(gaster)" EXACT [FMA:14911] synonym: "stratum circulare gastris" EXACT [] synonym: "stratum circulare tunicae muscularis gastricae" EXACT OMO:0003011 [FMA:14911, FMA:TA] xref: FMA:14911 xref: MA:0001628 xref: SCTID:2746007 is_a: UBERON:0012368 ! circular muscle layer of muscular coat relationship: BFO:0000050 UBERON:0008856 {source="FMA"} ! part of stomach muscularis externa relationship: BSPO:0000107 UBERON:0002439 ! myenteric nerve plexus relationship: BSPO:0000108 UBERON:0008862 ! stomach smooth muscle inner oblique layer relationship: RO:0002433 UBERON:0008856 ! contributes to morphology of stomach muscularis externa [Term] id: UBERON:0008858 name: pyloric canal def: "The short narrow part of the stomach extending from the pyloric antrum to the pyloric sphincter." [MP:0010791, Wikipedia:Pyloric_canal] subset: pheno_slim synonym: "canalis pyloricus" EXACT [Wikipedia:Pyloric_canal] synonym: "canalis pyloricus" RELATED OMO:0003011 [Wikipedia:Pyloric_canal] xref: EMAPA:37944 {source="MA:th"} xref: FMA:14580 xref: SCTID:245417002 xref: Wikipedia:Pyloric_canal is_a: UBERON:0009870 {source="FMA"} ! zone of stomach relationship: BFO:0000050 UBERON:0001166 {source="Wikipedia"} ! part of pylorus relationship: RO:0002150 UBERON:0001165 ! continuous with pyloric antrum relationship: RO:0002150 UBERON:0001202 ! continuous with pyloric sphincter relationship: RO:0002433 UBERON:0001166 ! contributes to morphology of pylorus property_value: foaf:depiction "https://upload.wikimedia.org/wikipedia/commons/3/33/Illu_stomach.jpg" xsd:anyURI property_value: skos:prefLabel "pyloric canal" xsd:string [Term] id: UBERON:0008859 name: cardiac gastric gland def: "A gastric gland in the cardiac region of the stomach; cardiac glands are fewer in number than in the fundus and body, and secrete mucin which coats the stomach and protects it[MP]." [MP:0010795, Wikipedia:Cardiac_glands] subset: organ_slim subset: pheno_slim synonym: "cardiac gland" RELATED [FMA:14920] synonym: "gardiac gland" EXACT [ISBN:0073040584] synonym: "gastric cardiac gland" EXACT [FMA:14920] synonym: "gastric cardiac mucuous gland" EXACT [] synonym: "gastric gland of cardia" EXACT [FMA:14920] synonym: "glandula cardiaca (gaster)" EXACT [FMA:14920] xref: EMAPA:37459 {source="MA:th"} xref: FMA:14920 xref: SCTID:8894005 xref: Wikipedia:Cardiac_glands is_a: UBERON:0000325 ! gastric gland is_a: UBERON:0000414 {source="MP"} ! mucous gland intersection_of: UBERON:0000325 ! gastric gland intersection_of: BFO:0000050 UBERON:0001162 ! part of cardia of stomach relationship: BFO:0000050 UBERON:0004996 {source="FMA"} ! part of mucosa of cardia of stomach relationship: RO:0002433 UBERON:0001162 ! contributes to morphology of cardia of stomach [Term] id: UBERON:0008861 name: pyloric gastric gland def: "The gastric glands in the pyloric region of the stomach; the pyloric glands secrete mucin, which coats the stomach and protects it, and hormones such as gastrin and enkephalin[MP]." [MP:0010797, Wikipedia:Pyloric_gland] subset: pheno_slim synonym: "glandula pylorica" EXACT [FMA:14922] synonym: "pyloric antrum gland" EXACT [OBOL:automatic] synonym: "pyloric gland" EXACT [FMA:14922] synonym: "pyloric mucuous gland" EXACT [] xref: EMAPA:27211 xref: FMA:14922 xref: NCIT:C33431 xref: SCTID:70710007 xref: UMLS:C0227239 {source="ncithesaurus:Pyloric_Gland"} xref: Wikipedia:Pyloric_gland is_a: UBERON:0000325 ! gastric gland is_a: UBERON:0000414 {source="MP"} ! mucous gland intersection_of: UBERON:0000325 ! gastric gland intersection_of: BFO:0000050 UBERON:0001166 ! part of pylorus relationship: BFO:0000050 UBERON:0004998 ! part of mucosa of pylorus relationship: RO:0000086 PATO:0002299 {source="Wikipedia:Tubular_gland"} ! has quality tubular relationship: RO:0002433 UBERON:0001166 ! contributes to morphology of pylorus property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/b/bf/Gray1054.png" xsd:anyURI property_value: IAO:0000116 "check relationship to pylorus vs antrum" xsd:string property_value: skos:prefLabel "pyloric gastric gland" xsd:string [Term] id: UBERON:0008862 name: stomach smooth muscle inner oblique layer def: "The innermost layer of the muscularis; it is not present in all sections of the stomach but is clearly seen in the fundus and near the lesser curvature of the corpus; the oblique fibers disappear distally (towards the pyloric antrum); the oblique layer is responsible for creating the motion that churns and physically breaks down the food." [MP:0010804] comment: The only layer of the three which is not seen in other parts of the digestive system[WP]. subset: pheno_slim synonym: "inner oblique muscle layer of stomach" EXACT [] synonym: "oblique fiber layer of gastric muscularis" EXACT [FMA:14912] synonym: "oblique muscle layer of stomach" EXACT [FMA:14912] xref: EMAPA:37965 {source="MA:th"} xref: FMA:14912 is_a: UBERON:0034933 ! layer of smooth muscle tissue relationship: BFO:0000050 UBERON:0008856 {source="MP"} ! part of stomach muscularis externa relationship: BSPO:0000107 UBERON:0008857 ! stomach smooth muscle circular layer relationship: RO:0002433 UBERON:0008856 ! contributes to morphology of stomach muscularis externa [Term] id: UBERON:0008870 name: pulmonary alveolar parenchyma def: "The distinguishing cell types of the lung alveolar tissue, including pulmonary epithelial cells (pneumocytes), alveolar capillary endothelial cells, interstitial cells (fibroblasts) and alveolar macrophages." [MP:0010901] subset: human_reference_atlas subset: pheno_slim xref: EMAPA:37942 {source="MA:th"} is_a: BFO:0000002 is_a: UBERON:0008946 ! lung parenchyma intersection_of: UBERON:0000353 ! parenchyma intersection_of: BFO:0000050 UBERON:0002299 ! part of alveolus of lung relationship: BFO:0000050 UBERON:0002299 ! part of alveolus of lung relationship: BFO:0000051 CL:0002062 ! has part pulmonary alveolar type 1 cell relationship: BFO:0000051 CL:0002063 ! has part pulmonary alveolar type 2 cell relationship: BFO:0000051 CL:0009089 ! has part lung pericyte relationship: RO:0002433 UBERON:0006524 ! contributes to morphology of alveolar system property_value: RO:0002175 NCBITaxon:9606 property_value: terms:contributor https://orcid.org/0000-0001-6677-8489 [Term] id: UBERON:0008874 name: pulmonary acinus def: "The largest lung subunit in which all airways participate in gas exchange, and it is composed of the parenchyma of the respiratory bronchioles, alveolar ducts, and alveoli." [MP:0010911, PMID:2014492, PMID:3382030, Wikipedia:Acinus#The_Lungs] subset: human_reference_atlas subset: pheno_slim synonym: "acinus pulmonaris" EXACT OMO:0003011 [FMA:7313, FMA:TA] synonym: "arbor alveolaris" EXACT OMO:0003011 [FMA:7313, FMA:TA] synonym: "pulmonary acini" EXACT OMO:0003004 [PMID:37025383] xref: EMAPA:37941 {source="MA:th"} xref: FMA:7313 xref: NCIT:C33426 xref: SCTID:361365004 xref: UMLS:C0225696 {source="ncithesaurus:Pulmonary_Acinus"} xref: Wikipedia:Acinus#The_Lungs is_a: BFO:0000004 is_a: UBERON:0001062 ! anatomical entity relationship: BFO:0000050 UBERON:0010369 ! part of secondary pulmonary lobule relationship: RO:0002170 UBERON:0002187 ! connected to terminal bronchiole property_value: RO:0002175 NCBITaxon:9606 property_value: terms:contributor https://orcid.org/0000-0001-6677-8489 [Term] id: UBERON:0008876 name: hypodermis skeletal muscle layer def: "Any skeletal muscle organ in the hypodermis / superficial fascia." [ISBN:0123813611, MP:0011157] subset: pheno_slim synonym: "hypodermal muscle layer" EXACT [MP:0011157] synonym: "hypodermis muscle layer" EXACT [MP:0011157] synonym: "panniculus carnosus" NARROW [MP:0011157] synonym: "superficial fascia muscular layer" EXACT [] xref: EMAPA:18188 xref: MA:0003140 is_a: UBERON:0004253 ! skin muscle is_a: UBERON:0014892 ! skeletal muscle organ, vertebrate intersection_of: UBERON:0014892 ! skeletal muscle organ, vertebrate intersection_of: BFO:0000050 UBERON:0002072 ! part of hypodermis relationship: BFO:0000050 UBERON:0002072 ! part of hypodermis relationship: RO:0001025 UBERON:0002190 {source="MP-def"} ! located in subcutaneous adipose tissue relationship: RO:0002373 UBERON:0002097 ! has muscle insertion skin of body relationship: RO:0002433 UBERON:0001015 ! contributes to morphology of musculature relationship: RO:0002433 UBERON:0002072 ! contributes to morphology of hypodermis property_value: IAO:0000116 "We follow MP and treat this as part of the hypodermis, although some sources may consider the hypodermis to be superficial to this" xsd:string property_value: skos:prefLabel "hypodermis skeletal muscle layer" xsd:string [Term] id: UBERON:0008877 name: epidermal-dermal junction def: "The multi-layer basement membrane between the dermis and epidermis that serves to adhere the dermis and epidermis, provide mechanical support for the epidermis, and forms a barrier to cells and large molecules across the junction." [MP:0011159] subset: pheno_slim synonym: "dermal-epidermal junction" EXACT [FMA:70963] synonym: "dermo-epidermal junction" EXACT [] synonym: "dermoepidermal junction" EXACT [FMA:70963] synonym: "epidermal dermol junction" EXACT [] xref: EMAPA:37866 {source="MA:th"} xref: FMA:70963 xref: NCIT:C62356 xref: SCTID:51025007 is_a: UBERON:0005769 ! basement membrane of epithelium relationship: BFO:0000050 UBERON:0000014 {source="MP"} ! part of zone of skin relationship: RO:0002220 UBERON:0001003 ! adjacent to skin epidermis relationship: RO:0002220 UBERON:0002067 ! adjacent to dermis relationship: RO:0002433 UBERON:0000014 ! contributes to morphology of zone of skin [Term] id: UBERON:0008882 name: spinal cord commissure def: "The nerve fiber tracts that span the midline of the spinal cord." [MP:0009694] subset: pheno_slim xref: EMAPA:37955 {source="MA:th"} is_a: UBERON:0001020 ! nervous system commissure is_a: UBERON:0007699 ! tract of spinal cord intersection_of: UBERON:0001020 ! nervous system commissure intersection_of: BFO:0000050 UBERON:0002240 ! part of spinal cord relationship: RO:0002433 UBERON:0002240 ! contributes to morphology of spinal cord property_value: skos:prefLabel "spinal cord commissure" xsd:string [Term] id: UBERON:0008883 name: osteoid def: "Bone tissue that is an unmineralized bone matrix deposited by osteoblasts prior to the mineralization of bone tissue." [GO_REF:0000034, http://dx.plos.org/10.1371/journal.pone.0051070, VSAO:0000046] subset: pheno_slim synonym: "osteoid tissue" EXACT [http://orcid.org/0000-0002-6601-2165] synonym: "pre-bone" EXACT [PSPUB:0000170] synonym: "prebone" EXACT [VSAO:curator] synonym: "prebone tissue" EXACT [FMA:66830, MP:0002113] xref: EMAPA:37923 {source="MA:th"} xref: FMA:66830 xref: galen:Osteoid xref: NCIT:C33228 xref: SCTID:39365008 xref: UMLS:C0682561 {source="ncithesaurus:Osteoid"} xref: VSAO:0000046 xref: Wikipedia:Osteoid xref: XAO:0004035 is_a: UBERON:0002481 {source="VSAO"} ! bone tissue property_value: foaf:depiction "https://upload.wikimedia.org/wikipedia/commons/9/9c/Active_osteoblasts.jpg" xsd:anyURI [Term] id: UBERON:0008884 name: left putamen def: "A putamen that is part of a left cerebral hemisphere." [OBOL:automatic] xref: FMA:72829 xref: HBA:4288 is_a: UBERON:0001874 ! putamen intersection_of: UBERON:0001874 ! putamen intersection_of: BFO:0000050 UBERON:0002812 ! part of left cerebral hemisphere relationship: BFO:0000050 UBERON:0002812 ! part of left cerebral hemisphere property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/brain-female/v1.4/assets/3d-allen-f-brain.glb" xsd:anyURI property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/brain-male/v1.4/assets/3d-allen-m-brain.glb" xsd:anyURI property_value: skos:prefLabel "left putamen" xsd:string [Term] id: UBERON:0008885 name: right putamen def: "A putamen that is part of a right cerebral hemisphere." [OBOL:automatic] xref: FMA:72828 xref: HBA:4289 is_a: UBERON:0001874 ! putamen intersection_of: UBERON:0001874 ! putamen intersection_of: BFO:0000050 UBERON:0002813 ! part of right cerebral hemisphere relationship: BFO:0000050 UBERON:0002813 ! part of right cerebral hemisphere property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/brain-female/v1.4/assets/3d-allen-f-brain.glb" xsd:anyURI property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/brain-male/v1.4/assets/3d-allen-m-brain.glb" xsd:anyURI property_value: skos:prefLabel "right putamen" xsd:string [Term] id: UBERON:0008886 name: pulmonary vascular system def: "The part of the cardiovascular system consisting of all pulmonary arteries and all pulmonary veins." [ISBN:0073040584, Wikipedia:Pulmonary_circulation] subset: human_reference_atlas synonym: "pulmonary circulatory system" EXACT [FMA:45621] synonym: "pulmonary system" EXACT [ISBN:0073040584] xref: FMA:45621 xref: Wikipedia:Pulmonary_circulation is_a: BFO:0000002 is_a: UBERON:0007798 {source="Obol"} ! vascular system relationship: BFO:0000051 UBERON:0002012 ! has part pulmonary artery relationship: BFO:0000051 UBERON:0002016 ! has part pulmonary vein property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "pulmonary vascular system" xsd:string [Term] id: UBERON:0008887 name: rectal venous plexus def: "The hemorrhoidal plexus (or rectal venous plexus) surrounds the rectum, and communicates in front with the vesical venous plexus in the male, and the uterovaginal plexus in the female. A free communication between the portal and systemic venous systems is established through the hemorrhoidal plexus." [Wikipedia:Rectal_venous_plexus] synonym: "haemorrhoidal plexus" RELATED [Wikipedia:Rectal_venous_plexus] synonym: "hemorrhoidal plexus" RELATED [Wikipedia:Rectal_venous_plexus] synonym: "plexus haemorrhoidalis" RELATED OMO:0003011 [Wikipedia:Rectal_venous_plexus] synonym: "plexus venosus rectalis" RELATED OMO:0003011 [Wikipedia:Rectal_venous_plexus] xref: FMA:18933 xref: NCIT:C32728 xref: SCTID:303051005 xref: UMLS:C0226766 {source="ncithesaurus:Hemorrhoidal_Plexus"} xref: Wikipedia:Rectal_venous_plexus is_a: UBERON:0001593 {source="FMA"} ! venous plexus intersection_of: UBERON:0001593 ! venous plexus intersection_of: RO:0002221 UBERON:0001052 ! surrounds rectum relationship: RO:0002221 UBERON:0001052 ! surrounds rectum property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/6/69/Gray587.png" xsd:anyURI property_value: skos:prefLabel "rectal venous plexus" xsd:string [Term] id: UBERON:0008895 name: splanchnocranium def: "Subdivision of endoskeleton derived from pharyngeal arches." [https://orcid.org/0000-0002-6601-2165, ISBN:0073040584, Wikipedia:Facial_skeleton] subset: human_reference_atlas synonym: "branchial arch skeleton" RELATED [] synonym: "gill arch skeleton" RELATED [] synonym: "pharyngeal arch" RELATED INCONSISTENT [VSAO:0000149] synonym: "pharyngeal arch skeleton" RELATED [ZFA:0001216] synonym: "pharyngeal endoskeleton" EXACT [http://orcid.org/0000-0002-6601-2165] synonym: "pharyngeal skeleton" RELATED [ZFA:0001216] synonym: "visceral cranium" RELATED [http://orcid.org/0000-0002-6601-2165] synonym: "visceral skeletal system" RELATED [http://orcid.org/0000-0002-6601-2165] synonym: "visceral skeleton" RELATED [UBERONREF:0000007] synonym: "viscerocranium" EXACT INCONSISTENT [VHOG:0000315, Wikipedia:Viscerocranium, ZFA:0001216] xref: AAO:0010157 xref: TAO:0001216 xref: VHOG:0000315 xref: VSAO:0000149 xref: Wikipedia:Facial_skeleton xref: XAO:0003176 xref: ZFA:0001216 is_a: BFO:0000002 is_a: UBERON:0011159 ! primary subdivision of cranial skeletal system disjoint_from: UBERON:0011156 ! facial skeleton relationship: RO:0002202 UBERON:0002539 {source="https://github.com/obophenotype/uberon/issues/83"} ! develops from pharyngeal arch relationship: RO:0002254 UBERON:0003099 ! has developmental contribution from cranial neural crest property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/7/77/Illu_facial_bones.jpg" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "splanchnocranium" xsd:string [Term] id: UBERON:0008896 name: post-hyoid pharyngeal arch def: "A pharyngeal arch that is posterior to the hyoid arch. i.e. any pharyngeal arch with a number 3 or higher." [https://orcid.org/0000-0002-6601-2165] subset: efo_slim synonym: "branchial arch" EXACT [ZFA:0001613] synonym: "branchial arches" EXACT OMO:0003004 [ZFA:0001613] synonym: "branchial bar" EXACT [ZFA:0001613] synonym: "branchial bars" EXACT OMO:0003004 [ZFA:0001613] synonym: "gill arch" EXACT [ZFA:0001613] synonym: "gill arches 1-5" EXACT [ZFA:0001613] synonym: "gill bar" RELATED [https://orcid.org/0000-0002-6601-2165] synonym: "pharyngeal arch 3-7" EXACT [ZFA:0001613] synonym: "visceral arches 3-7" EXACT [ZFA:0001613] xref: AAO:0010362 xref: BTO:0002152 xref: EFO:0003694 xref: TAO:0001597 xref: XAO:0000099 xref: ZFA:0001613 is_a: UBERON:0002539 ! pharyngeal arch intersection_of: UBERON:0002539 ! pharyngeal arch intersection_of: BSPO:0000099 UBERON:0003066 ! pharyngeal arch 2 relationship: BSPO:0000099 UBERON:0003066 ! pharyngeal arch 2 property_value: skos:prefLabel "post-hyoid pharyngeal arch" xsd:string [Term] id: UBERON:0008904 name: neuromast def: "Volcano-shaped lateral line sensory organ located in characteristic positions within the skin epithelium and containing hair cells and their support elements." [ZFIN:ZDB-PUB-961014-576] subset: efo_slim synonym: "lateral line neuromast" EXACT [ZFA:0000243] synonym: "lateral line organ" BROAD [ZFA:0000243] synonym: "neuromast organ" EXACT [PHENOSCAPE:wd] synonym: "neuromasts" EXACT OMO:0003004 [ZFA:0000243] xref: AAO:0001004 xref: EFO:0003513 xref: TAO:0000243 xref: ZFA:0000243 is_a: UBERON:0004121 ! ectoderm-derived structure is_a: UBERON:0035555 ! lateral line sense organ relationship: BFO:0000050 UBERON:0010202 ! part of lateral line relationship: BFO:0000051 CL:0000856 ! has part neuromast hair cell relationship: RO:0001025 UBERON:0001003 ! located in skin epidermis relationship: RO:0002202 UBERON:0009128 {source="DOI:10.1038/ncomms1502"} ! develops from lateral line placode relationship: RO:0002494 UBERON:2005227 {source="ZFA"} ! transformation of protoneuromast [Term] id: UBERON:0008906 name: lateral line nerve def: "Cranial nerves that carry afferent and efferent fibers for the lateral line system." [ZFIN:curator] synonym: "lateral line nerves" EXACT OMO:0003004 [ZFA:0001479] xref: AAO:0010077 xref: TAO:0001479 xref: ZFA:0001479 is_a: UBERON:0001785 ! cranial nerve is_a: UBERON:0004121 ! ectoderm-derived structure intersection_of: UBERON:0001785 ! cranial nerve intersection_of: extends_fibers_into UBERON:0008904 ! neuromast intersection_of: extends_fibers_into UBERON:3010706 ! lateral line nucleus relationship: BFO:0000050 UBERON:0002540 ! part of lateral line system relationship: extends_fibers_into UBERON:0008904 ! neuromast relationship: extends_fibers_into UBERON:3010706 ! lateral line nucleus relationship: RO:0002202 UBERON:0009128 {source="NCBIBook:NBK53175"} ! develops from lateral line placode [Term] id: UBERON:0008907 name: dermal bone def: "Skeletal element that forms superficially in the organism, usually in association with the ectoderm[VSAO]." [GO_REF:0000034, http://dx.plos.org/10.1371/journal.pone.0051070, https://github.com/obophenotype/uberon/issues/267, VSAO:0000130] synonym: "dermal bones" RELATED OMO:0003004 [ZFA:0001590] xref: AAO:0010769 xref: TAO:0001590 xref: VSAO:0000130 xref: Wikipedia:Dermal_bone xref: XAO:0004015 xref: ZFA:0001590 is_a: UBERON:0004756 {source="wd"} ! dermal skeletal element is_a: UBERON:0007842 {source="VSAO"} ! membrane bone intersection_of: UBERON:0001474 ! bone element intersection_of: BFO:0000050 UBERON:0010364 ! part of dermal skeleton relationship: BFO:0000050 UBERON:0010364 {source="VSAO"} ! part of dermal skeleton property_value: skos:prefLabel "dermal bone" xsd:string [Term] id: UBERON:0008909 name: perichordal bone def: "Bone element that is adjacent to the notochord." [GO_REF:0000034, http://dx.plos.org/10.1371/journal.pone.0051070, VSAO:0000307] synonym: "perichordal bone" RELATED [ZFA:0001629] synonym: "perichordal bones" EXACT OMO:0003004 [ZFA:0001629] xref: AAO:0010777 xref: TAO:0001639 xref: VSAO:0000307 xref: ZFA:0001629 is_a: UBERON:0012075 ! replacement bone intersection_of: UBERON:0001474 ! bone element intersection_of: RO:0002220 UBERON:0002328 ! adjacent to notochord relationship: RO:0002220 UBERON:0002328 ! adjacent to notochord property_value: IAO:0000116 "We go with the latest VSAO in making this a subtype of bone, and add a logical definition based on the textual definition in VSAO. We also include the subtyping under 'replacement bone', for consistency with ZFA" xsd:string property_value: skos:prefLabel "perichordal bone" xsd:string [Term] id: UBERON:0008921 name: substratum of layer of retina def: "Missing definition for term UBERON:0008921. Please replace it using linked reference." [UBERON:CL_meeting_20110725] is_a: UBERON:0022303 ! nervous system cell part layer relationship: BFO:0000050 UBERON:0000966 ! part of retina [Term] id: UBERON:0008922 name: sublaminar layer S1 def: "A retinal neural layer that is immediately adjacent to the inner nuclear layer and comprises 20 percent of the inner plexiform layer of retina." [GOC:tfm] xref: CP:0000113 is_a: UBERON:0008927 ! sublaminar layers S1 or S2 is_a: UBERON:0009735 ! sublaminar layers S1 or S3 or S4 intersection_of: UBERON:0008921 ! substratum of layer of retina intersection_of: RO:0002220 UBERON:0001791 ! adjacent to inner nuclear layer of retina intersection_of: RO:0002220 UBERON:0008923 ! adjacent to sublaminar layer S2 relationship: BFO:0000050 UBERON:0008927 ! part of sublaminar layers S1 or S2 relationship: RO:0002220 UBERON:0001791 ! adjacent to inner nuclear layer of retina relationship: RO:0002220 UBERON:0008923 ! adjacent to sublaminar layer S2 [Term] id: UBERON:0008923 name: sublaminar layer S2 def: "A retinal neural layer that is immediately adjacent to the S1 and S3 layers and comprises 20 percent of the inner plexiform layer of retina." [GOC:tfm] xref: CP:0000114 is_a: UBERON:0008927 ! sublaminar layers S1 or S2 is_a: UBERON:0008928 ! sublaminar layers S2 or S3 intersection_of: UBERON:0008921 ! substratum of layer of retina intersection_of: RO:0002220 UBERON:0008922 ! adjacent to sublaminar layer S1 intersection_of: RO:0002220 UBERON:0008924 ! adjacent to sublaminar layer S3 relationship: BFO:0000050 UBERON:0008927 ! part of sublaminar layers S1 or S2 relationship: BFO:0000050 UBERON:0008928 ! part of sublaminar layers S2 or S3 relationship: RO:0002220 UBERON:0008922 ! adjacent to sublaminar layer S1 relationship: RO:0002220 UBERON:0008924 ! adjacent to sublaminar layer S3 [Term] id: UBERON:0008924 name: sublaminar layer S3 def: "A retinal neural layer that is immediately adjacent to the S2 and S4 layers and comprises 20 percent of the inner plexiform layer of retina." [GOC:tfm] xref: CP:0000115 is_a: UBERON:0008928 ! sublaminar layers S2 or S3 is_a: UBERON:0009731 ! sublaminar layers S3 or S4 intersection_of: UBERON:0008921 ! substratum of layer of retina intersection_of: RO:0002220 UBERON:0008923 ! adjacent to sublaminar layer S2 intersection_of: RO:0002220 UBERON:0008925 ! adjacent to sublaminar layer S4 relationship: BFO:0000050 UBERON:0008928 ! part of sublaminar layers S2 or S3 relationship: RO:0002220 UBERON:0008923 ! adjacent to sublaminar layer S2 relationship: RO:0002220 UBERON:0008925 ! adjacent to sublaminar layer S4 [Term] id: UBERON:0008925 name: sublaminar layer S4 def: "A retinal neural layer that is immediately adjacent to the S3 and S5 layer and comprises 20 percent of the inner plexiform layer of retina." [GOC:tfm] xref: CP:0000116 is_a: UBERON:0008929 ! sublaminar layers S4 or S5 is_a: UBERON:0009731 ! sublaminar layers S3 or S4 intersection_of: UBERON:0008921 ! substratum of layer of retina intersection_of: RO:0002220 UBERON:0008924 ! adjacent to sublaminar layer S3 intersection_of: RO:0002220 UBERON:0008926 ! adjacent to sublaminar layer S5 relationship: BFO:0000050 UBERON:0008929 ! part of sublaminar layers S4 or S5 relationship: RO:0002220 UBERON:0008924 ! adjacent to sublaminar layer S3 relationship: RO:0002220 UBERON:0008926 ! adjacent to sublaminar layer S5 [Term] id: UBERON:0008926 name: sublaminar layer S5 def: "A retinal neural layer that is immediately adjacent to the retinal ganglion cell layer and comprises 20 percent of the ganglion plexiform layer of retina." [GOC:tfm] xref: CP:0000117 is_a: UBERON:0008929 ! sublaminar layers S4 or S5 is_a: UBERON:0009732 ! sublaminar layers S1 or S2 or S5 intersection_of: UBERON:0008921 ! substratum of layer of retina intersection_of: RO:0002220 UBERON:0001792 ! adjacent to ganglionic layer of retina intersection_of: RO:0002220 UBERON:0008925 ! adjacent to sublaminar layer S4 relationship: BFO:0000050 UBERON:0008929 ! part of sublaminar layers S4 or S5 relationship: RO:0002220 UBERON:0001792 ! adjacent to ganglionic layer of retina relationship: RO:0002220 UBERON:0008925 ! adjacent to sublaminar layer S4 [Term] id: UBERON:0008927 name: sublaminar layers S1 or S2 def: "One of sublaminar layers S1 or S2." [GOC:tfm, https://github.com/obophenotype/uberon/issues/31] xref: CP:0000118 is_a: UBERON:0009732 ! sublaminar layers S1 or S2 or S5 is_a: UBERON:0009733 ! sublaminar layers S1 or S2 or S3 union_of: UBERON:0008922 ! sublaminar layer S1 union_of: UBERON:0008923 ! sublaminar layer S2 relationship: BFO:0000050 UBERON:0001795 ! part of inner plexiform layer of retina property_value: terms:contributor https://orcid.org/0000-0002-6601-2165 property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 [Term] id: UBERON:0008928 name: sublaminar layers S2 or S3 def: "One of sublaminar layers S2 or S3." [GOC:tfm, https://github.com/obophenotype/uberon/issues/31] xref: CP:0000119 is_a: UBERON:0009733 ! sublaminar layers S1 or S2 or S3 is_a: UBERON:0009734 ! sublaminar layers S2 or S3 or S4 union_of: UBERON:0008923 ! sublaminar layer S2 union_of: UBERON:0008924 ! sublaminar layer S3 relationship: BFO:0000050 UBERON:0001795 ! part of inner plexiform layer of retina property_value: terms:contributor https://orcid.org/0000-0002-6601-2165 property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 [Term] id: UBERON:0008929 name: sublaminar layers S4 or S5 def: "One of sublaminar layers S4 or S5." [GOC:tfm, https://github.com/obophenotype/uberon/issues/31] xref: CP:0000120 is_a: UBERON:0009736 ! sublaminar layers S3 or S4 or S5 union_of: UBERON:0008925 ! sublaminar layer S4 union_of: UBERON:0008926 ! sublaminar layer S5 relationship: BFO:0000050 UBERON:0001795 ! part of inner plexiform layer of retina property_value: terms:contributor https://orcid.org/0000-0002-6601-2165 property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 [Term] id: UBERON:0008946 name: lung parenchyma def: "A parenchyma that is part of a lung." [OBOL:automatic] synonym: "parenchyma of lung" RELATED [BTO:0000763] synonym: "pulmonary parenchyma" RELATED [EMAPA:35522] synonym: "respiratory portion of lung" EXACT [FMA:27360] xref: EMAPA:35522 xref: FMA:27360 xref: MA:0003168 xref: SCTID:201712001 is_a: UBERON:0000353 {source="FMA"} ! parenchyma intersection_of: UBERON:0000353 ! parenchyma intersection_of: BFO:0000050 UBERON:0002048 ! part of lung relationship: BFO:0000050 UBERON:0002048 {source="FMA"} ! part of lung property_value: skos:prefLabel "lung parenchyma" xsd:string [Term] id: UBERON:0008947 name: respiratory primordium xref: EHDAA2:0004069 xref: NCIT:C34283 xref: UMLS:C1514898 {source="ncithesaurus:Respiratory_Primordium"} is_a: UBERON:0001048 {source="Obol"} ! primordium relationship: BFO:0000050 UBERON:0003258 ! part of endoderm of foregut relationship: RO:0002387 UBERON:0001004 ! has potential to develop into respiratory system property_value: skos:prefLabel "respiratory primordium" xsd:string [Term] id: UBERON:0008951 name: left lung lobe def: "A lobe of lung that is part of a left lung." [OBOL:automatic] synonym: "lobe of left lung" EXACT [] synonym: "lobe of the left lung" EXACT [] xref: EHDAA:2981 xref: NCIT:C48945 xref: SCTID:272655003 xref: UMLS:C1285107 {source="ncithesaurus:Lobe_of_the_Left_Lung"} is_a: UBERON:0000101 ! lobe of lung intersection_of: UBERON:0000101 ! lobe of lung intersection_of: BFO:0000050 UBERON:0002168 ! part of left lung relationship: BFO:0000050 UBERON:0002168 ! part of left lung property_value: skos:prefLabel "left lung lobe" xsd:string [Term] id: UBERON:0008962 name: forelimb bone def: "A bone that is part of a forelimb region. Examples: humerus, any of the phalanges. Counter-example: scapula (a bone of the pectoral girdle). Note that we consider the forelimb to end at the shoulder." [https://orcid.org/0000-0002-6601-2165] synonym: "free forelimb bone" EXACT [https://orcid.org/0000-0002-6601-2165, UBERONREF:0000003] synonym: "wing bone" NARROW SENSU [Geisha:syn, NCBITaxon:8782, OBOL:automatic] xref: GAID:178 xref: MESH:D001133 xref: NCIT:C12983 xref: SCTID:368532003 xref: UMLS:C0003793 {source="ncithesaurus:Bone_of_the_Upper_Extremity"} is_a: UBERON:0002428 ! limb bone is_a: UBERON:0010741 ! bone of pectoral complex is_a: UBERON:0015021 ! forelimb endochondral element intersection_of: UBERON:0015021 ! forelimb endochondral element intersection_of: RO:0002473 UBERON:0002481 ! composed primarily of bone tissue relationship: RO:0002202 UBERON:0010883 ! develops from forelimb cartilage element [Term] id: UBERON:0008969 name: dental follicle def: "A sac containing the developing tooth and its odontogenic organ. The dental follicle (DF) differentiates into the periodontal ligament. In addition, it may be the precursor of other cells of the periodontium, including osteoblasts, cementoblasts and fibroblasts. They develop into the alveolar bone, the cementum with Sharpey's fibers and the periodontal ligament fibers respectively." [Wikipedia:Dental_follicle] synonym: "dental sac" RELATED [MA:0003121, Wikipedia:Dental_follicle] synonym: "tooth follicle" RELATED [BTO:0000337] xref: BTO:0000337 xref: EMAPA:35275 xref: MA:0003121 xref: MESH:D003795 {sssom:mapping_justification="https://w3id.org/semapv/vocab/LexicalMatching"} xref: NCIT:C34138 xref: SCTID:110975002 xref: Wikipedia:Dental_follicle is_a: UBERON:0007499 ! epithelial sac is_a: UBERON:0010313 ! neural crest-derived structure is_a: UBERON:0010371 ! ecto-epithelium relationship: BFO:0000050 UBERON:0008281 ! part of tooth bud relationship: BFO:0000051 CL:0007002 ! has part precementoblast [Term] id: UBERON:0008974 name: apocrine gland def: "Any exocrine gland whose cells bud their secretions off through the plasma membrane producing membrane-bound vesicles in the lumen; the apical portion of the secretory cell of the gland pinches off and enters the lumen; it loses part of its cytoplasm in their secretions; apocrine secretion is functional during hormonal stress or puberty; an example of true apocrine glands are mammary glands, responsible for secreting breast milk." [MGI:anna] subset: human_reference_atlas subset: organ_slim subset: pheno_slim synonym: "true apocrine gland" EXACT [] xref: BTO:0001162 xref: EMAPA:35141 xref: MA:0003040 xref: SCTID:361698000 xref: Wikipedia:Apocrine is_a: UBERON:0002365 ! exocrine gland disjoint_from: UBERON:0010243 {source="cjm"} ! merocrine gland property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0008987 name: renal parenchyma def: "The functional tissue of the kidney, consisting of the nephrons." [BTO:0003604] synonym: "kidney parenchyma" RELATED [BTO:0003604] synonym: "parenchyma of kidney" EXACT [FMA:15574] xref: BTO:0003604 xref: FMA:15574 xref: SCTID:29704000 is_a: UBERON:0000353 {source="FMA"} ! parenchyma intersection_of: UBERON:0000353 ! parenchyma intersection_of: BFO:0000050 UBERON:0002113 ! part of kidney relationship: BFO:0000050 UBERON:0002113 {source="FMA"} ! part of kidney [Term] id: UBERON:0008989 name: submucosal esophageal gland def: "One of the racemose glands in the walls of the esophagus that in humans are small and serve principally to lubricate the food but in some birds secrete a milky fluid on which the young are fed." [BTO:0003634, Wikipedia:Esophageal_glands] synonym: "esophageal gland" EXACT [FMA:9404] synonym: "glandulae oesophageae" EXACT [Wikipedia:Esophageal_glands] synonym: "mucous gland of submucosa of esophagus" EXACT [FMA:9404] synonym: "submocosal esophageal gland" RELATED [] xref: BTO:0003634 xref: FMA:9404 xref: NCIT:C32536 xref: SCTID:322749003 xref: UMLS:C0227178 {source="ncithesaurus:Esophageal_Gland"} xref: Wikipedia:Esophageal_glands is_a: UBERON:0003408 ! gland of digestive tract is_a: UBERON:0011148 ! submucosal gland intersection_of: UBERON:0011148 ! submucosal gland intersection_of: BFO:0000050 UBERON:0001043 ! part of esophagus relationship: BFO:0000050 UBERON:0001043 ! part of esophagus relationship: RO:0001025 UBERON:0001972 ! located in submucosa of esophagus property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/e/e8/Illu_esophageal_layers.jpg" xsd:anyURI property_value: skos:prefLabel "submucosal esophageal gland" xsd:string [Term] id: UBERON:0008995 name: nucleus of cerebellar nuclear complex def: "Four accumulations of gray substance embedded in the white substance of the cerebellum, comprising the nucleus dentatus, nucleus emboliformis, nucleus globosus, and nucleus fastigii." [BTO:0003835] subset: pheno_slim synonym: "cerebellar nucleus" EXACT [BTO:0003835] synonym: "deep cerebellar nucleus" EXACT [] xref: BTO:0003835 xref: EMAPA:35272 xref: FMA:321695 xref: MA:0000203 xref: SCTID:279220006 is_a: UBERON:0009662 ! hindbrain nucleus intersection_of: UBERON:0002308 ! nucleus of brain intersection_of: BFO:0000050 UBERON:0002130 ! part of cerebellar nuclear complex relationship: BFO:0000050 UBERON:0002130 ! part of cerebellar nuclear complex relationship: RO:0002433 UBERON:0002037 ! contributes to morphology of cerebellum property_value: RO:0002175 NCBITaxon:119203 {source="ISBN:0471888893"} property_value: RO:0002175 NCBITaxon:1476529 property_value: RO:0002175 NCBITaxon:32524 property_value: RO:0002175 NCBITaxon:7878 property_value: RO:0002175 NCBITaxon:7896 property_value: RO:0002175 NCBITaxon:8292 property_value: skos:prefLabel "nucleus of cerebellar nuclear complex" xsd:string [Term] id: UBERON:0008998 name: vasculature of brain def: "System pertaining to blood vessels in the brain." [BTO:0003840] subset: efo_slim synonym: "brain vasculature" EXACT [] synonym: "cerebrovascular system" EXACT [BTO:0003840] synonym: "intracerebral vasculature" EXACT [FMA:61935] xref: BTO:0003840 xref: EFO:0003491 xref: EMAPA:35186 xref: FMA:242007 xref: FMA:61935 xref: SCTID:362029003 xref: TAO:0000099 xref: ZFA:0000099 is_a: UBERON:0006876 ! vasculature of organ is_a: UBERON:0036303 ! vasculature of central nervous system relationship: BFO:0000050 UBERON:0000955 ! part of brain property_value: skos:prefLabel "vasculature of brain" xsd:string [Term] id: UBERON:0009010 name: periurethral tissue def: "Any portion of tissue that surrounds a urethra." [UBERON:cjm] xref: BTO:0005081 xref: SCTID:256880003 is_a: UBERON:0000479 ! tissue intersection_of: UBERON:0000479 ! tissue intersection_of: RO:0002221 UBERON:0000057 ! surrounds urethra relationship: BFO:0000050 UBERON:0001556 ! part of lower urinary tract relationship: RO:0002221 UBERON:0000057 ! surrounds urethra [Term] id: UBERON:0009014 name: lower back skin def: "A zone of skin that is part of a lower back." [OBOL:automatic] subset: organ_slim xref: EMAPA:37281 {source="MA:th"} xref: MA:0000504 xref: SCTID:286601005 is_a: UBERON:0001068 ! skin of back is_a: UBERON:0003836 {source="MA"} ! abdominal segment skin intersection_of: UBERON:0000014 ! zone of skin intersection_of: BFO:0000050 UBERON:0005462 ! part of lower back relationship: BFO:0000050 UBERON:0005462 ! part of lower back [Term] id: UBERON:0009015 name: upper back skin def: "A zone of skin that is part of a dorsal thoracic segment of trunk." [OBOL:automatic] xref: EMAPA:37280 {source="MA:th"} xref: MA:0000510 xref: SCTID:304890003 is_a: UBERON:0001068 ! skin of back is_a: UBERON:0001418 {source="MA"} ! skin of thorax intersection_of: UBERON:0000014 ! zone of skin intersection_of: BFO:0000050 UBERON:0008231 ! part of dorsal thoracic segment of trunk relationship: BFO:0000050 UBERON:0008231 ! part of dorsal thoracic segment of trunk property_value: skos:prefLabel "upper back skin" xsd:string [Term] id: UBERON:0009027 name: vesical artery def: "An artery that supplies blood to the urinary bladder." [http://orcid.org/0000-0002-6601-2165] synonym: "arteria vesicali" EXACT OMO:0003011 [] synonym: "vesical arteries" EXACT OMO:0003004 [] xref: EMAPA:37131 {source="MA:th"} xref: MA:0002078 xref: SCTID:244307000 is_a: UBERON:0001637 ! artery intersection_of: UBERON:0001637 ! artery intersection_of: RO:0020101 UBERON:0001255 ! vessel supplies blood to urinary bladder relationship: RO:0020101 UBERON:0001255 ! vessel supplies blood to urinary bladder [Term] id: UBERON:0009029 name: pudendal vein def: "Either the internal or external pudendal vein, running from the genital-vulvar area and abdomen and down the leg." [http://orcid.org/0000-0002-6601-2165, https://veintreatmentcenter.com/vein-information/pudendal-veins/] synonym: "pudic vein" RELATED [] synonym: "vena pudendae" EXACT OMO:0003011 [doi:10.1002/ca.23705] synonym: "vena pudendales" EXACT OMO:0003011 [doi:10.1002/ca.23705] xref: EMAPA:37184 {source="MA:th"} xref: MA:0002202 xref: SCTID:395225000 is_a: UBERON:0001638 {source="MA"} ! vein is_a: UBERON:0003520 ! pelvis blood vessel [Term] id: UBERON:0009030 name: left pulmonary vein def: "Vein that drains left lung and returns blood to the heart." [http://orcid.org/0000-0002-6601-2165] xref: EMAPA:37165 {source="MA:th"} xref: MA:0002207 xref: NCIT:C48946 xref: SCTID:304057004 xref: UMLS:C0226670 {source="ncithesaurus:Left_Pulmonary_Vein"} is_a: UBERON:0002016 ! pulmonary vein intersection_of: UBERON:0002016 ! pulmonary vein intersection_of: RO:0020102 UBERON:0002168 ! vessel drains blood from left lung relationship: RO:0020102 UBERON:0002168 ! vessel drains blood from left lung property_value: skos:prefLabel "left pulmonary vein" xsd:string [Term] id: UBERON:0009032 name: right pulmonary vein def: "Vein that drains right lung and returns blood to the heart." [http://orcid.org/0000-0002-6601-2165] xref: EMAPA:37379 {source="MA:th"} xref: MA:0002208 xref: NCIT:C48947 xref: SCTID:304056008 xref: UMLS:C0226669 {source="ncithesaurus:Right_Pulmonary_Vein"} is_a: UBERON:0002016 ! pulmonary vein intersection_of: UBERON:0002016 ! pulmonary vein intersection_of: RO:0020102 UBERON:0002167 ! vessel drains blood from right lung relationship: RO:0020102 UBERON:0002167 ! vessel drains blood from right lung property_value: skos:prefLabel "right pulmonary vein" xsd:string [Term] id: UBERON:0009035 name: renal straight tubule def: "Any region of a nephron tubule that is straight. Examples: distal convoluted tubule, proximal convoluted tuble." [http://orcid.org/0000-0002-6601-2165] synonym: "kidney straight tubule" EXACT [MA:0002634] synonym: "straight tubule" EXACT [] xref: EMAPA:37489 {source="MA:th"} xref: MA:0002634 xref: SCTID:245151008 xref: Wikipedia:Tubuli_seminiferi_recti is_a: UBERON:0007685 ! region of nephron tubule [Term] id: UBERON:0009039 name: lymph node germinal center def: "A germinal center that is located in a lymph node." [CL:tm] subset: human_reference_atlas subset: pheno_slim synonym: "germinal center" BROAD [BTO:0003671] synonym: "lymph node activated zone" RELATED [] synonym: "lymph node central zone" RELATED [] synonym: "lymph node light zone" NARROW [] synonym: "lymph node nodule" RELATED [] xref: BTO:0003671 xref: CALOHA:TS-1269 xref: EMAPA:35528 xref: MA:0002989 xref: NCIT:C49757 xref: SCTID:327147000 is_a: UBERON:0010754 ! germinal center intersection_of: UBERON:0010754 ! germinal center intersection_of: BFO:0000050 UBERON:0000029 ! part of lymph node relationship: BFO:0000050 UBERON:0010753 {source="MA"} ! part of lymph node secondary follicle property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0009042 name: prostatic venous plexus def: "The prostatic veins form a well-marked prostatic plexus which lies partly in the fascial sheath of the prostate and partly between the sheath and the prostatic capsule. It communicates with the pudendal and vesical plexuses." [Wikipedia:Prostatic_venous_plexus] subset: human_reference_atlas synonym: "plexus venosus prostaticus" RELATED OMO:0003011 [Wikipedia:Prostatic_venous_plexus] synonym: "pudendal venous plexus" RELATED [FMA:29711] xref: FMA:29711 xref: SCTID:303052003 xref: Wikipedia:Prostatic_venous_plexus is_a: UBERON:0001593 ! venous plexus is_a: UBERON:0006876 ! vasculature of organ intersection_of: UBERON:0001593 ! venous plexus intersection_of: BFO:0000050 UBERON:0002367 ! part of prostate gland relationship: BFO:0000050 UBERON:0002367 ! part of prostate gland property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/b/bd/Gray585.png" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0009089 name: inner medulla descending vasa recta xref: KUPO:0001003 is_a: UBERON:0000064 ! organ part relationship: BFO:0000050 UBERON:0004776 {source="KUPO"} ! part of inner renal medulla vasa recta [Term] id: UBERON:0009090 name: outer medulla descending vasa recta xref: KUPO:0001004 is_a: UBERON:0000064 ! organ part relationship: BFO:0000050 UBERON:0004775 {source="KUPO"} ! part of outer renal medulla vasa recta [Term] id: UBERON:0009091 name: ascending vasa recta subset: human_reference_atlas xref: KUPO:0001005 is_a: UBERON:0000064 ! organ part relationship: BFO:0000050 UBERON:0004726 {source="KUPO"} ! part of vasa recta property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0009092 name: inner medulla ascending vasa recta xref: KUPO:0001006 is_a: UBERON:0000064 ! organ part relationship: BFO:0000050 UBERON:0004776 {source="KUPO"} ! part of inner renal medulla vasa recta [Term] id: UBERON:0009093 name: outer medulla ascending vasa recta xref: KUPO:0001007 is_a: UBERON:0000064 ! organ part relationship: BFO:0000050 UBERON:0004775 {source="KUPO"} ! part of outer renal medulla vasa recta [Term] id: UBERON:0009095 name: tip of renal papilla subset: human_reference_atlas synonym: "papillary tip" EXACT [KUPO:0001009] synonym: "papillary tips" EXACT OMO:0003004 [KUPO:0001009] xref: KUPO:0001009 is_a: UBERON:0000064 ! organ part relationship: BFO:0000050 UBERON:0001228 {source="KUPO"} ! part of renal papilla property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0009097 name: gravid organism def: "An organism containing a developing embryo, fetus, or unborn offspring within the body." [BTO:0004733] synonym: "gravid" RELATED [BTO:0004733] synonym: "pregnant adult" RELATED [BTO:0004733] synonym: "pregnant adult stage" RELATED [BTO:0004733] synonym: "pregnant organism" RELATED [] synonym: "pregnant stage" RELATED [BTO:0004733] xref: BTO:0004733 xref: IDOMAL:0000443 {sssom:mapping_justification="https://w3id.org/semapv/vocab/LexicalMatching"} is_a: BFO:0000002 is_a: UBERON:0007023 ! adult organism intersection_of: UBERON:0007023 ! adult organism intersection_of: BFO:0000051 UBERON:0000922 ! has part embryo relationship: BFO:0000051 UBERON:0000922 ! has part embryo relationship: RO:0000056 GO:0007565 ! participates in female pregnancy relationship: RO:0002162 NCBITaxon:6072 ! in taxon Eumetazoa [Term] id: UBERON:0009098 name: gravid uterus def: "The uterus in pregnancy." [http://medical-dictionary.thefreedictionary.com/gravid+uterus] synonym: "womb" RELATED [] xref: NCIT:C12406 xref: ncithesaurus:Gravid_Uterus xref: SCTID:362253003 xref: UMLS:C1514389 {source="ncithesaurus:Pregnant_Uterus"} is_a: UBERON:0000995 ! uterus intersection_of: UBERON:0000995 ! uterus intersection_of: RO:0001015 UBERON:0000922 ! location of embryo relationship: BFO:0000050 UBERON:0009097 ! part of gravid organism relationship: BFO:0000067 GO:0007565 ! contains process female pregnancy relationship: RO:0001015 UBERON:0000922 ! location of embryo [Term] id: UBERON:0009114 name: cervical thymus def: "A mature thymus that is entirely part of the cervical region." [https://orcid.org/0000-0002-6601-2165] subset: organ_slim is_a: UBERON:0002370 ! thymus intersection_of: UBERON:0002370 ! thymus intersection_of: BFO:0000050 UBERON:0000974 ! part of neck relationship: BFO:0000050 UBERON:0000974 ! part of neck property_value: RO:0002175 NCBITaxon:39107 property_value: RO:0002175 NCBITaxon:9263 [Term] id: UBERON:0009115 name: thoracic thymus def: "A mature thymus that is entirely part of thoracic region." [https://orcid.org/0000-0002-6601-2165] subset: organ_slim is_a: UBERON:0002370 ! thymus is_a: UBERON:0005178 ! thoracic cavity element intersection_of: UBERON:0002370 ! thymus intersection_of: BFO:0000050 UBERON:0000915 ! part of thoracic segment of trunk [Term] id: UBERON:0009117 name: indifferent gonad def: "A gonad prior to differentiating into a definitive testis or ovary." [http://www.medterms.com/script/main/art.asp?articlekey=8981] comment: typically part of the embryo - however, in male tammar wallabies the gonads are indifferent at the neonatal stage[8827321] subset: organ_slim synonym: "gonad rudiment" RELATED [] xref: EHDAA2:0000716 xref: NCIT:C34192 xref: UMLS:C1512703 {source="ncithesaurus:Indifferent_Gonad"} is_a: UBERON:0000991 ! gonad relationship: BFO:0000050 UBERON:0009196 ! part of indifferent external genitalia property_value: skos:prefLabel "indifferent gonad" xsd:string [Term] id: UBERON:0009122 name: adenohypophyseal placode def: "The adenohypophyseal placode forms the anterior lobe of the pituitary gland and gives rise to the endocrine secretory cells of the pituitary." [http://www.ncbi.nlm.nih.gov/books/NBK53175/] subset: efo_slim synonym: "pituitary placode" RELATED [ZFA:0001198] xref: EFO:0000229 xref: TAO:0001198 xref: XAO:0004208 xref: ZFA:0001198 is_a: BFO:0000002 is_a: UBERON:0002546 ! cranial placode is_a: UBERON:0011814 {source="NCBIBook:NBK53175"} ! non-neurogenic ectodermal placode relationship: RO:0002202 UBERON:0005497 {source="ZFA"} ! develops from non-neural ectoderm property_value: IAO:0000116 "consider adding more detailed spatial placement - e.g. oral ectoderm and/or rostal ectoderm" xsd:string property_value: skos:prefLabel "adenohypophyseal placode" xsd:string [Term] id: UBERON:0009124 name: geniculate placode def: "Rostralmost epibranchial placode. Associated with 1st branchial cleft." [NCBIBook:NBK53175] comment: Taxonomic equivalence to EHDAA2 class made on basis of shared development: gives rise to geniculate ganglion synonym: "epibranchial placode 1" EXACT [EHDAA2:0004206] synonym: "facial epibranchial placode" EXACT [XAO:0004211] synonym: "facial placode" EXACT [ZFA:0001295] synonym: "facial VII placode" RELATED [] synonym: "hyoid placode" RELATED [ISBN:0471888893] synonym: "hyoid VII placode" RELATED [ISBN:0471888893] xref: EHDAA2:0004206 xref: TAO:0001295 xref: XAO:0004211 xref: ZFA:0001295 is_a: UBERON:0003078 {source="ZFA"} ! epibranchial placode property_value: skos:prefLabel "geniculate placode" xsd:string [Term] id: UBERON:0009125 name: petrosal placode def: "Epibranchial placode between geniculate and nodose. Associated with 2nd branchial cleft." [NCBIBook:NBK53175] comment: Taxonomic equivalence to EHDAA2 class made on basis of shared development: gives rise to glossopharyngeal ganglion synonym: "epibranchial placode 2" EXACT [EHDAA2:0004207] synonym: "glossopharyngeal epibranchial placode" EXACT [XAO:0004212] synonym: "glossopharyngeal IX placode" EXACT [ISBN:0471888893] synonym: "glossopharyngeal placode" EXACT [ISBN:0471888893, ZFA:0001296] xref: EHDAA2:0004207 xref: TAO:0001296 xref: XAO:0004212 xref: ZFA:0001296 is_a: UBERON:0003078 {source="ZFA"} ! epibranchial placode property_value: skos:prefLabel "petrosal placode" xsd:string [Term] id: UBERON:0009126 name: nodosal placode def: "Caudalmost epibranchial placode. Associated with 3rd branchial cleft." [NCBIBook:NBK53175] comment: Taxonomic equivalence to EHDAA2 class made on basis of shared development: Gives rise to inferior vagus ganglion. Note that ZFA has 4 vagal placodes synonym: "epibranchial placode 3" EXACT [EHDAA2:0004208] synonym: "nodose placode" EXACT [XAO:0004213] synonym: "nodose placodes" EXACT OMO:0003004 [XAO:0004213] synonym: "vagal epibranchial placode" EXACT [XAO:0004213] synonym: "vagal epibranchial placodes" EXACT OMO:0003004 [XAO:0004213] synonym: "vagal placode" RELATED [ISBN:0471888893] synonym: "vagal X placode" RELATED [ISBN:0471888893] xref: EHDAA2:0004208 xref: XAO:0004213 is_a: UBERON:0003078 {source="NCBIBook:NBK53175"} ! epibranchial placode [Term] id: UBERON:0009127 name: epibranchial ganglion def: "Cranial ganglion which develops from an epibranchial placode." [PMID:20133851, ZFIN:curator] comment: Epibranchial ganglia orchestrate the development of the cranial neurogenic crest subset: human_reference_atlas synonym: "epibranchial ganglia" EXACT OMO:0003004 [ZFA:0001555] xref: TAO:0001555 xref: ZFA:0001555 is_a: UBERON:0001714 {source="ZFA"} ! cranial ganglion is_a: UBERON:0004121 ! ectoderm-derived structure intersection_of: UBERON:0001714 ! cranial ganglion intersection_of: RO:0002202 UBERON:0003078 ! develops from epibranchial placode relationship: RO:0002202 UBERON:0003078 {source="NCBIBook:NBK53175"} ! develops from epibranchial placode property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "epibranchial ganglion" xsd:string [Term] id: UBERON:0009128 name: lateral line placode def: "An ectodermal placode that will develop into the components of the lateral line system." [http://orcid.org/0000-0002-6601-2165] synonym: "lateral line placodes" RELATED OMO:0003004 [XAO:0000440] xref: AAO:0010718 xref: XAO:0000440 is_a: UBERON:0003067 {source="ISBN:0471888893"} ! dorsolateral placode intersection_of: UBERON:0005085 ! ectodermal placode intersection_of: RO:0002387 UBERON:0002540 ! has potential to develop into lateral line system relationship: RO:0002387 UBERON:0002540 ! has potential to develop into lateral line system property_value: IAO:0000116 "TODO - compare with protoneuromast" xsd:string property_value: RO:0002161 NCBITaxon:32524 {source="http://tolweb.org/Amniota"} [Term] id: UBERON:0009129 name: right atrium endocardium def: "Endocardium that is part of the right atrium." [http://orcid.org/0000-0002-6601-2165] synonym: "endocardium of right atrium" EXACT [FMA:7281] synonym: "right atrial endocardium" EXACT [FMA:7281] synonym: "right atrium endocardial tissue" RELATED [VHOG:0001228] xref: EHDAA2:0000274 xref: FMA:7281 xref: NCIT:C102339 xref: SCTID:3194006 xref: VHOG:0001228 is_a: UBERON:0002166 ! endocardium of atrium intersection_of: UBERON:0002165 ! endocardium intersection_of: BFO:0000050 UBERON:0002078 ! part of right cardiac atrium relationship: BFO:0000050 UBERON:0002078 ! part of right cardiac atrium relationship: BFO:0000050 UBERON:0006218 {source="EHDAA2"} ! part of common atrial chamber relationship: RO:0002202 UBERON:0005092 {source="EHDAA2"} ! develops from right horn of sinus venosus property_value: skos:prefLabel "right atrium endocardium" xsd:string [Term] id: UBERON:0009133 name: pleuroperitoneal membrane def: "A fold of tissue which extends into the peritoneal cavity of the developing embryo and participates in the separation of the pleural and peritoneal cavities." [http://medical-dictionary.thefreedictionary.com/pleuroperitoneal+membrane, Wikipedia:Pleuroperitoneal] synonym: "pleuroperitoneal fold" EXACT [VHOG:0000757] synonym: "pleuroperitoneal membranes" EXACT OMO:0003004 [EHDAA2:0001483] xref: EHDAA2:0001483 xref: EMAPA:17709 xref: NCIT:C34256 xref: SCTID:361429005 xref: UMLS:C1283968 {source="ncithesaurus:Pleuroperitoneal_Membrane"} xref: VHOG:0000757 xref: Wikipedia:Pleuroperitoneal is_a: UBERON:0002050 {source="EHDAA2"} ! embryonic structure is_a: UBERON:0005291 ! embryonic tissue relationship: RO:0002220 UBERON:0001179 ! adjacent to peritoneal cavity relationship: RO:0002220 UBERON:0002402 ! adjacent to pleural cavity property_value: skos:prefLabel "pleuroperitoneal membrane" xsd:string [Term] id: UBERON:0009141 name: craniocervical region vein def: "A vein that is part of a craniocervical region." [OBOL:automatic] synonym: "craniocervical vein" EXACT [] synonym: "head and neck veins" EXACT [EHDAA2:0004542] synonym: "vein of head and neck" EXACT [] xref: EHDAA2:0004542 xref: SCTID:32945007 is_a: UBERON:0013140 ! systemic vein intersection_of: UBERON:0001638 ! vein intersection_of: BFO:0000050 UBERON:0007811 ! part of craniocervical region relationship: BFO:0000050 UBERON:0007811 ! part of craniocervical region property_value: skos:prefLabel "craniocervical region vein" xsd:string [Term] id: UBERON:0009142 name: entire embryonic mesenchyme def: "Sum total of mesenchyme in the embryo." [https://github.com/obophenotype/human-developmental-anatomy-ontology/issues/7] xref: EHDAA2:0001113 xref: EHDAA:177 xref: EMAPA:16097 is_a: BFO:0000002 is_a: BFO:0000004 is_a: UBERON:0000477 ! anatomical cluster relationship: BFO:0000050 UBERON:0000922 ! part of embryo relationship: RO:0002254 UBERON:0000926 {source="EHDAA2"} ! has developmental contribution from mesoderm relationship: RO:0002473 UBERON:0003104 ! composed primarily of mesenchyme property_value: IAO:0000116 "consider adding new class (EMAPA:16097) for mesenchyme of embryo (some mesenchyme is extraembryonic - e.g. amnion mesoderm)" xsd:string property_value: skos:prefLabel "entire embryonic mesenchyme" xsd:string [Term] id: UBERON:0009145 name: pharyngeal region of foregut synonym: "pharyngeal region" EXACT [EMAPA:16549] xref: EMAPA:16549 xref: RETIRED_EHDAA2:0001454 is_a: UBERON:0005423 ! developing anatomical structure relationship: BFO:0000050 UBERON:0001041 {source="EHDAA2"} ! part of foregut property_value: skos:prefLabel "pharyngeal region of foregut" xsd:string [Term] id: UBERON:0009191 name: sphenoid bone pre-cartilage condensation def: "A sphenoid endochondral element that is composed primarily of a pre-cartilage condensation." [OBOL:automatic] xref: EHDAA2:0003446 xref: EMAPA:18015 is_a: UBERON:0000481 {source="EHDAA2"} ! multi-tissue structure is_a: UBERON:0005866 {source="EHDAA2"} ! pre-cartilage condensation is_a: UBERON:0009891 ! facial mesenchyme is_a: UBERON:0015060 ! sphenoid endochondral element intersection_of: UBERON:0015060 ! sphenoid endochondral element intersection_of: RO:0002473 UBERON:0005866 ! composed primarily of pre-cartilage condensation relationship: BFO:0000050 UBERON:0001703 {source="EHDAA2"} ! part of neurocranium relationship: BFO:0000050 UBERON:0002241 {source="EHDAA2"} ! part of chondrocranium relationship: RO:0002473 UBERON:0005866 ! composed primarily of pre-cartilage condensation property_value: skos:prefLabel "sphenoid bone pre-cartilage condensation" xsd:string [Term] id: UBERON:0009193 name: sphenoid cartilage element def: "A sphenoid endochondral element that is composed primarily of cartilage tissue." [OBOL:automatic] synonym: "sphenoid bone cartilage condensation" EXACT [EHDAA2:0001888] xref: EHDAA2:0001888 is_a: UBERON:0003932 ! cartilage element of chondrocranium is_a: UBERON:0005863 {source="EHDAA2"} ! cartilaginous condensation is_a: UBERON:0009891 ! facial mesenchyme is_a: UBERON:0015060 ! sphenoid endochondral element intersection_of: UBERON:0015060 ! sphenoid endochondral element intersection_of: RO:0002473 UBERON:0002418 ! composed primarily of cartilage tissue relationship: RO:0002202 UBERON:0009191 ! develops from sphenoid bone pre-cartilage condensation property_value: skos:prefLabel "sphenoid cartilage element" xsd:string [Term] id: UBERON:0009196 name: indifferent external genitalia subset: organ_slim xref: EHDAA2:0004021 is_a: UBERON:0004176 {source="cjm"} ! external genitalia relationship: BFO:0000050 UBERON:0000922 ! part of embryo property_value: skos:prefLabel "indifferent external genitalia" xsd:string [Term] id: UBERON:0009198 name: craniofacial suture def: "Any suture between cranial and/or facial bones." [GO:0097094] synonym: "articulation of skull bones" RELATED [OBOL:automatic] synonym: "joint of the skull bones" EXACT [OBOL:automatic] is_a: UBERON:0002209 ! fibrous joint intersection_of: UBERON:0002209 ! fibrous joint intersection_of: RO:0002176 UBERON:0003457 {minCardinality="2"} ! connects head bone relationship: BFO:0000050 UBERON:0010323 ! part of cranial skeletal system relationship: RO:0002176 UBERON:0003457 ! connects head bone property_value: IAO:0000116 "we follow GO in dividing sutures into cranial and facial and making a grouping class, but this is not consistent with FMA" xsd:string property_value: skos:prefLabel "craniofacial suture" xsd:string [Term] id: UBERON:0009199 name: facial suture def: "Any suture between facial bones." [GO:0097096] is_a: UBERON:0009198 ! craniofacial suture intersection_of: UBERON:0009198 ! craniofacial suture intersection_of: RO:0002176 UBERON:0003462 {minCardinality="2"} ! connects facial bone relationship: BFO:0000050 UBERON:0011156 ! part of facial skeleton relationship: RO:0002176 UBERON:0003462 ! connects facial bone property_value: skos:prefLabel "facial suture" xsd:string [Term] id: UBERON:0009200 name: limb epidermis def: "The limb epidermis is the outer epithelial layer of the limb, it is a complex stratified squamous epithelium." [GOC:dph, GOC:sdb_2009, GOC:tb] xref: EMAPA:32728 is_a: UBERON:0001003 ! skin epidermis is_a: UBERON:3000981 ! limb external integument structure intersection_of: UBERON:0001003 ! skin epidermis intersection_of: BFO:0000050 UBERON:0002101 ! part of limb [Term] id: UBERON:0009201 name: nephric duct def: "A nephric duct is a tube that drains a primitive kidney[GO]." [GO:0072176] comment: pronephric duct or mesonephric duct xref: EMAPA:16577 xref: Wikipedia:Wolffian_duct is_a: UBERON:0003914 {source="EHDAA2"} ! epithelial tube is_a: UBERON:0004819 ! kidney epithelium is_a: UBERON:0006553 ! renal duct is_a: UBERON:0006555 ! excretory tube is_a: UBERON:0012275 ! meso-epithelium union_of: UBERON:0003060 ! pronephric duct union_of: UBERON:0003074 ! mesonephric duct [Term] id: UBERON:0009202 name: descending vasa recta subset: human_reference_atlas xref: KUPO:0001002 is_a: UBERON:0000064 ! organ part relationship: BFO:0000050 UBERON:0004726 {source="KUPO"} ! part of vasa recta property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0009204 name: medial nasal process mesenchyme def: "Mesenchyme that is part of a medial nasal prominence." [OBOL:automatic] xref: EHDAA2:0001077 xref: EMAPA:16810 xref: FMA:312659 is_a: UBERON:0009501 ! mesenchyme of fronto-nasal process intersection_of: UBERON:0003104 ! mesenchyme intersection_of: BFO:0000050 UBERON:0004068 ! part of medial nasal prominence disjoint_from: UBERON:0009205 {source="lexical"} ! lateral nasal process mesenchyme relationship: BFO:0000050 UBERON:0004068 {source="EHDAA2"} ! part of medial nasal prominence property_value: skos:prefLabel "medial nasal process mesenchyme" xsd:string [Term] id: UBERON:0009205 name: lateral nasal process mesenchyme def: "Mesenchyme that is part of a lateral nasal prominence." [OBOL:automatic] synonym: "mesenchyme of latero-nasal process" EXACT [EMAPA:16807] xref: EHDAA2:0000917 xref: EMAPA:16807 xref: FMA:312665 is_a: UBERON:0009501 ! mesenchyme of fronto-nasal process intersection_of: UBERON:0003104 ! mesenchyme intersection_of: BFO:0000050 UBERON:0004067 ! part of lateral nasal prominence relationship: BFO:0000050 UBERON:0004067 ! part of lateral nasal prominence [Term] id: UBERON:0009206 name: lateral nasal process surface ectoderm def: "An ectoderm that is part of a lateral nasal prominence." [OBOL:automatic] synonym: "ectoderm of latero-nasal process" EXACT [EMAPA:16806] xref: EHDAA2:0000918 xref: EMAPA:16806 is_a: UBERON:0000924 ! ectoderm is_a: UBERON:0014702 ! frontonasal process epithelium intersection_of: UBERON:0000924 ! ectoderm intersection_of: BFO:0000050 UBERON:0004067 ! part of lateral nasal prominence relationship: BFO:0000050 UBERON:0000076 {source="EHDAA2"} ! part of external ectoderm relationship: BFO:0000050 UBERON:0004067 ! part of lateral nasal prominence [Term] id: UBERON:0009210 name: pharyngeal membrane def: "A thin fold of ectoderm and endoderm that separates the pharyngeal pouches from the pharyngeal clefts in a developing embryo." [http://musom.marshall.edu/anatomy/grosshom/z_devbranc.html] comment: each membrane is initially composed of an inner layer formed by the endodermal lining of a branchial pouch and an outer layer formed by the ectodermal lining of the branchial groove; later, these two layers become separated by a thin layer of mesoderm; only the first branchial membrane contributes to the formation of an adult structure, i.e. the tympanic membrane (aka eardrum); the second, third, and fourth membranes are obliterated[MP] subset: pheno_slim synonym: "branchial arch membrane" EXACT [EMAPA:32749] synonym: "branchial membrane" EXACT [] synonym: "pharyngeal membrane" EXACT [] xref: EMAPA:32749 xref: FMA:295758 xref: NCIT:C34251 xref: UMLS:C1519040 {source="ncithesaurus:Pharyngeal_Membrane"} is_a: BFO:0000002 is_a: UBERON:0002050 ! embryonic structure relationship: BFO:0000050 UBERON:0002539 {source="EMAPA"} ! part of pharyngeal arch relationship: BFO:0000051 UBERON:0000924 ! has part ectoderm relationship: BFO:0000051 UBERON:0000925 ! has part endoderm relationship: RO:0002131 UBERON:0004117 ! overlaps pharyngeal pouch relationship: RO:0002131 UBERON:0005879 ! overlaps pharyngeal cleft [Term] id: UBERON:0009213 name: pharyngeal membrane of 1st arch def: "A pharyngeal membrane that separates the first pharyngeal cleft from the first pharyngeal pouch." [http://orcid.org/0000-0002-6601-2165] synonym: "1st branchial membrane" EXACT [EMAPA:16992] synonym: "1st pharyngeal membrane" EXACT [VHOG:0001427] synonym: "future tympanic membrane" EXACT [EMAPA:17281] synonym: "tympanic membrane primordium" EXACT [ISBN:1416037055] xref: EHDAA:3788 xref: EMAPA:16121 xref: EMAPA:16992 xref: EMAPA:17281 xref: VHOG:0001427 is_a: UBERON:0009210 ! pharyngeal membrane relationship: BFO:0000050 UBERON:0004362 {source="EMAPA"} ! part of pharyngeal arch 1 relationship: RO:0002131 UBERON:0005872 ! overlaps 1st arch pharyngeal cleft relationship: RO:0002131 UBERON:0007122 ! overlaps pharyngeal pouch 1 property_value: IAO:0000116 "check EMAPA - 3 terms appear to match. We follow EMAPA in making each membrane part of the arch with the same number, though in fact it is between these arches" xsd:string [Term] id: UBERON:0009291 name: cartilaginous vertebral centrum def: "Cartilaginous form of a vertebral centrum, a skeletal element that functionally replaces the notochord[VSAP,modified]." [http://orcid.org/0000-0002-6601-2165, VSAO:0000183, VSAO:curator] comment: cartilaginous centrum of vertebra[PMID:11746457] synonym: "cartilaginous centrum of vertebra" EXACT [] synonym: "postcaudal cartilaginous centrum" NARROW [PMID:11746457] xref: SCTID:317278007 is_a: UBERON:0007844 ! cartilage element is_a: UBERON:0016491 ! vertebral centrum element intersection_of: UBERON:0016491 ! vertebral centrum element intersection_of: RO:0002473 UBERON:0002418 ! composed primarily of cartilage tissue relationship: BFO:0000050 UBERON:0011094 ! part of vertebra cartilage element [Term] id: UBERON:0009292 name: embryonic nasal process synonym: "nasal placode" RELATED [] xref: EHDAA2:0000581 xref: EHDAA:4776 xref: EMAPA:16680 xref: SCTID:308881001 is_a: UBERON:0012314 ! embryonic facial prominence property_value: skos:prefLabel "embryonic nasal process" xsd:string [Term] id: UBERON:0009471 name: dorsum of tongue def: "The superior surface of the tongue divided by the sulcus terminalis into an anterior two-thirds, the presulcal part (pars presulcalis). and a posterior one-third, the postsulcal part (pars postsulcalis)." [http://www.drugs.com/dict/dorsum-of-tongue.html] subset: human_reference_atlas synonym: "dorsal tongue" EXACT [FMA:54651] synonym: "dorsum linguae" EXACT [http://www.drugs.com/dict/dorsum-of-tongue.html] synonym: "tongue dorsum" EXACT [FMA:54651] xref: FMA:54651 xref: NCIT:C32482 xref: SCTID:66938003 xref: UMLS:C0226952 {source="ncithesaurus:Dorsum_of_the_Tongue"} is_a: UBERON:0000064 ! organ part relationship: BFO:0000050 UBERON:0001723 {source="FMA"} ! part of tongue property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "dorsum of tongue" xsd:string [Term] id: UBERON:0009472 name: axilla def: "The axilla is the area directly under the joint where the forelimb connects to the shoulder." [Wikipedia:Axilla] subset: efo_slim subset: pheno_slim synonym: "arm pit" EXACT [Wikipedia:Axilla] synonym: "armpit" EXACT [Wikipedia:Axilla] synonym: "armpits" RELATED [Wikipedia:Axilla] synonym: "axilla" RELATED OMO:0003011 [Wikipedia:Axilla] synonym: "axillae" RELATED [Wikipedia:Axilla] synonym: "axillary region" EXACT [FMA:24864] synonym: "axillary region" RELATED [Wikipedia:Axilla] synonym: "oxter" RELATED [Wikipedia:Axilla] synonym: "regio axillaris" EXACT OMO:0003011 [FMA:TA] synonym: "underarm" RELATED [Wikipedia:Axilla] xref: CALOHA:TS-2208 xref: EFO:0001395 xref: FMA:24864 xref: galen:Axilla xref: MESH:D001365 xref: NCIT:C12674 xref: SCTID:362732006 xref: UMLS:C0004454 {source="ncithesaurus:Axilla"} xref: Wikipedia:Axilla is_a: UBERON:0034929 ! external soft tissue zone relationship: BFO:0000050 UBERON:0001421 {source="FMA"} ! part of pectoral girdle region property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/f/f2/Gray411.png" xsd:anyURI [Term] id: UBERON:0009477 name: associated mesenchyme of otic placode def: "Mesenchyme that is part of a otic placode." [OBOL:automatic] subset: emapa_ehdaa2 xref: EHDAA2:0001340 xref: EMAPA:16196 is_a: UBERON:0007213 ! mesenchyme derived from head neural crest intersection_of: UBERON:0003104 ! mesenchyme intersection_of: BFO:0000050 UBERON:0003069 ! part of otic placode relationship: BFO:0000050 UBERON:0003069 ! part of otic placode relationship: RO:0002202 UBERON:0007213 ! develops from mesenchyme derived from head neural crest property_value: skos:prefLabel "associated mesenchyme of otic placode" xsd:string [Term] id: UBERON:0009479 name: ectoderm of buccopharyngeal membrane def: "An ectoderm that is part of a buccopharyngeal membrane." [OBOL:automatic] subset: emapa_ehdaa2 xref: EHDAA2:0000190 xref: EMAPA:16260 is_a: UBERON:0000924 ! ectoderm intersection_of: UBERON:0000924 ! ectoderm intersection_of: BFO:0000050 UBERON:0006211 ! part of buccopharyngeal membrane relationship: BFO:0000050 UBERON:0006211 ! part of buccopharyngeal membrane property_value: skos:prefLabel "ectoderm of buccopharyngeal membrane" xsd:string [Term] id: UBERON:0009480 name: endoderm of buccopharyngeal membrane def: "An endoderm that is part of a buccopharyngeal membrane." [OBOL:automatic] subset: emapa_ehdaa2 xref: EHDAA2:0000191 xref: EMAPA:16261 is_a: UBERON:0000925 ! endoderm intersection_of: UBERON:0000925 ! endoderm intersection_of: BFO:0000050 UBERON:0006211 ! part of buccopharyngeal membrane relationship: BFO:0000050 UBERON:0006211 ! part of buccopharyngeal membrane property_value: skos:prefLabel "endoderm of buccopharyngeal membrane" xsd:string [Term] id: UBERON:0009482 name: associated mesenchyme of foregut-midgut junction def: "Mesenchyme that is part of a foregut-midgut junction." [OBOL:automatic] subset: emapa_ehdaa2 xref: EHDAA2:0000570 xref: EMAPA:16364 is_a: UBERON:0003104 ! mesenchyme intersection_of: UBERON:0003104 ! mesenchyme intersection_of: BFO:0000050 UBERON:0006235 ! part of foregut-midgut junction relationship: BFO:0000050 UBERON:0006235 ! part of foregut-midgut junction property_value: skos:prefLabel "associated mesenchyme of foregut-midgut junction" xsd:string [Term] id: UBERON:0009483 name: mesentery of foregut-midgut junction def: "A mesentery that is part of a foregut-midgut junction." [OBOL:automatic] subset: emapa_ehdaa2 synonym: "foregut-midgut junction mesentery" EXACT [VHOG:0000430] xref: EHDAA2:0000575 xref: EMAPA:16365 xref: VHOG:0000430 is_a: UBERON:0002095 ! mesentery intersection_of: UBERON:0002095 ! mesentery intersection_of: BFO:0000050 UBERON:0006235 ! part of foregut-midgut junction relationship: BFO:0000050 UBERON:0006235 ! part of foregut-midgut junction [Term] id: UBERON:0009494 name: pharyngeal arch mesenchymal region def: "A portion of mesenchymal tissue associated with an individual pharyngeal arch." [https://orcid.org/0000-0002-6601-2165] subset: pheno_slim synonym: "branchial arch mesenchyme" EXACT [MP:0011262] synonym: "pharyngeal arch mesenchyme" EXACT [https://orcid.org/0000-0002-6601-2165] xref: EMAPA:32755 xref: FMA:295694 is_a: UBERON:0005291 ! embryonic tissue is_a: UBERON:0007524 {source="EHDAA2"} ! dense mesenchyme tissue intersection_of: UBERON:0003104 ! mesenchyme intersection_of: BFO:0000050 UBERON:0002539 ! part of pharyngeal arch relationship: BFO:0000050 UBERON:0002539 ! part of pharyngeal arch relationship: BFO:0000050 UBERON:0010046 ! part of entire pharyngeal arch associated mesenchyme relationship: RO:0002254 UBERON:0003099 {source="cjm"} ! has developmental contribution from cranial neural crest property_value: IAO:0000116 "this represents a part of the entire arch mesenchyme (UBERON:0010046), and is therefore a superclass of the individual arch mesenchyme classes. Alternate definition: primordial embryonic connective tissue associated with the branchial arches, consisting of mesenchymal cells supported in interlaminar jelly, that derive mostly from the mesoderm and contribute to facial and cranial nerve-associated structures." xsd:string {source="MP:0011262"} property_value: skos:prefLabel "pharyngeal arch mesenchymal region" xsd:string [Term] id: UBERON:0009497 name: epithelium of foregut-midgut junction def: "An epithelium that is part of a foregut-midgut junction." [OBOL:automatic] subset: emapa_ehdaa2 xref: EHDAA2:0000573 xref: EMAPA:16564 is_a: UBERON:0000490 ! unilaminar epithelium is_a: UBERON:0003929 ! digestive tract epithelium is_a: UBERON:0005911 ! endo-epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: BFO:0000050 UBERON:0006235 ! part of foregut-midgut junction relationship: BFO:0000050 UBERON:0003929 {source="EHDAA2"} ! part of digestive tract epithelium relationship: BFO:0000050 UBERON:0006235 ! part of foregut-midgut junction relationship: RO:0002202 UBERON:0009550 {source="EHDAA2"} ! develops from endoderm of foregut-midgut junction property_value: skos:prefLabel "epithelium of foregut-midgut junction" xsd:string [Term] id: UBERON:0009500 name: periotic mesenchyme def: "Anatomical region that surrounds the otic vesicle." [PMID:3794595, XAO:0004474, XAO:curators] subset: emapa_ehdaa2 synonym: "otocyst associated mesenchyme" EXACT [EHDAA2:0001343] synonym: "otocyst mesenchyme" EXACT [EMAPA:16670] synonym: "periotic region" RELATED [XAO:0004474] xref: EHDAA2:0001343 xref: EMAPA:16670 xref: XAO:0004474 is_a: UBERON:0007213 ! mesenchyme derived from head neural crest intersection_of: UBERON:0003104 ! mesenchyme intersection_of: RO:0002221 UBERON:0003051 ! surrounds ear vesicle relationship: BFO:0000050 UBERON:0001444 {source="XAO"} ! part of subdivision of head relationship: RO:0002202 UBERON:0009477 {source="EHDAA2"} ! develops from associated mesenchyme of otic placode relationship: RO:0002221 UBERON:0003051 ! surrounds ear vesicle property_value: skos:prefLabel "periotic mesenchyme" xsd:string [Term] id: UBERON:0009501 name: mesenchyme of fronto-nasal process def: "The embryonic connective tissue made up of loosely aggregated mesenchymal cells, supported by interlaminar jelly, that gives rise to the frontonasal region of the head." [MP:0011266] subset: emapa_ehdaa2 subset: pheno_slim synonym: "frontonasal mesenchyme" EXACT [MP:0011266] synonym: "naso-frontal mesenchyme" EXACT [MP:0011266] xref: EHDAA2:0004109 xref: EMAPA:16683 xref: FMA:295821 is_a: UBERON:0007213 ! mesenchyme derived from head neural crest intersection_of: UBERON:0003104 ! mesenchyme intersection_of: BFO:0000050 UBERON:0004066 ! part of frontonasal prominence relationship: BFO:0000050 UBERON:0004066 ! part of frontonasal prominence relationship: RO:0002202 UBERON:0007213 ! develops from mesenchyme derived from head neural crest property_value: skos:prefLabel "mesenchyme of fronto-nasal process" xsd:string [Term] id: UBERON:0009503 name: mesenchyme of hindgut def: "Mesenchyme that is part of a developing hindgut." [OBOL:automatic] subset: emapa_ehdaa2 synonym: "hindgut associated mesenchyme" EXACT [EHDAA2:0000780] xref: EHDAA2:0000780 xref: EMAPA:16716 is_a: UBERON:0003104 ! mesenchyme intersection_of: UBERON:0003104 ! mesenchyme intersection_of: BFO:0000050 UBERON:0001046 ! part of hindgut relationship: BFO:0000050 UBERON:0001046 ! part of hindgut property_value: skos:prefLabel "mesenchyme of hindgut" xsd:string [Term] id: UBERON:0009505 name: mesenchyme of trachea def: "Mesenchyme that is part of a developing trachea." [OBOL:automatic] subset: emapa_ehdaa2 synonym: "trachea associated mesenchyme" EXACT [EHDAA2:0002067] xref: EHDAA2:0002067 xref: EMAPA:16854 is_a: UBERON:0007524 {source="EHDAA2"} ! dense mesenchyme tissue intersection_of: UBERON:0003104 ! mesenchyme intersection_of: BFO:0000050 UBERON:0003126 ! part of trachea relationship: BFO:0000050 UBERON:0003126 ! part of trachea relationship: RO:0002202 UBERON:0002539 ! develops from pharyngeal arch property_value: skos:prefLabel "mesenchyme of trachea" xsd:string [Term] id: UBERON:0009506 name: mesenchyme of middle ear def: "Mesenchyme that is part of a developing middle ear." [OBOL:automatic] subset: emapa_ehdaa2 synonym: "middle ear associated mesenchyme" EXACT [EHDAA2:0001182] synonym: "otic mesenchyme" BROAD [] xref: EHDAA2:0001182 xref: EMAPA:17001 is_a: UBERON:0005253 ! head mesenchyme is_a: UBERON:0007524 {source="EHDAA2"} ! dense mesenchyme tissue intersection_of: UBERON:0003104 ! mesenchyme intersection_of: BFO:0000050 UBERON:0001756 ! part of middle ear relationship: BFO:0000050 UBERON:0001756 ! part of middle ear relationship: RO:0002254 UBERON:0005689 {source="EHDAA2"} ! has developmental contribution from 2nd arch mesenchyme relationship: RO:0002254 UBERON:0010045 {source="EHDAA2"} ! has developmental contribution from 1st arch maxillary mesenchyme [Term] id: UBERON:0009521 name: anal membrane endodermal component def: "An endoderm that is part of a anal region." [OBOL:automatic] subset: emapa_ehdaa2 xref: EHDAA2:0004020 xref: EMAPA:17177 is_a: UBERON:0000490 ! unilaminar epithelium is_a: UBERON:0005911 ! endo-epithelium intersection_of: UBERON:0000490 ! unilaminar epithelium intersection_of: BFO:0000050 UBERON:0001353 ! part of anal region intersection_of: RO:0002202 UBERON:0000925 ! develops from endoderm relationship: BFO:0000050 UBERON:0001353 ! part of anal region property_value: skos:prefLabel "anal membrane endodermal component" xsd:string [Term] id: UBERON:0009522 name: lateral lingual swelling epithelium def: "An epithelium that is part of a lateral lingual swelling." [OBOL:automatic] subset: emapa_ehdaa2 xref: EHDAA2:0000913 xref: EMAPA:17190 xref: FMA:313717 is_a: UBERON:0000490 ! unilaminar epithelium is_a: UBERON:0003929 ! digestive tract epithelium is_a: UBERON:0005291 ! embryonic tissue intersection_of: UBERON:0000483 ! epithelium intersection_of: BFO:0000050 UBERON:0006757 ! part of lateral lingual swelling relationship: BFO:0000050 UBERON:0006757 ! part of lateral lingual swelling property_value: skos:prefLabel "lateral lingual swelling epithelium" xsd:string [Term] id: UBERON:0009523 name: mesenchyme of handplate def: "Mesenchyme that is part of a handplate." [OBOL:automatic] subset: emapa_ehdaa2 synonym: "hand plate mesenchyme" EXACT [] synonym: "handplate mesenchyme" EXACT [EHDAA2:0000731] xref: EHDAA2:0000731 xref: EMAPA:17248 xref: EMAPA:17457 is_a: UBERON:0010377 ! mesenchyme from somatopleure intersection_of: UBERON:0003104 ! mesenchyme intersection_of: BFO:0000050 UBERON:0006875 ! part of embryonic handplate relationship: BFO:0000050 UBERON:0006875 ! part of embryonic handplate relationship: RO:0002202 UBERON:0003413 {source="EHDAA2"} ! develops from pectoral appendage bud mesenchyme [Term] id: UBERON:0009526 name: maxillary process mesenchyme def: "Mesenchyme that is part of a maxillary prominence." [OBOL:automatic] subset: emapa_ehdaa2 synonym: "mesenchyme of maxillary process" EXACT [EMAPA:17361] synonym: "mesenchyme of maxillary prominence" EXACT [https://orcid.org/0000-0002-6601-2165] xref: EHDAA2:0001071 xref: EMAPA:17361 xref: FMA:312691 is_a: UBERON:0003104 ! mesenchyme is_a: UBERON:0005291 ! embryonic tissue intersection_of: UBERON:0003104 ! mesenchyme intersection_of: BFO:0000050 UBERON:0005868 ! part of maxillary prominence relationship: BFO:0000050 UBERON:0005868 ! part of maxillary prominence property_value: skos:prefLabel "maxillary process mesenchyme" xsd:string [Term] id: UBERON:0009536 name: vascular element of left lung def: "A vascular plexus that is part of a left lung." [OBOL:automatic] subset: emapa_ehdaa2 xref: EHDAA2:0000963 xref: EMAPA:17660 is_a: UBERON:0000102 ! lung vasculature is_a: UBERON:0005629 ! vascular plexus intersection_of: UBERON:0005629 ! vascular plexus intersection_of: BFO:0000050 UBERON:0002168 ! part of left lung relationship: BFO:0000050 UBERON:0002168 ! part of left lung property_value: skos:prefLabel "vascular element of left lung" xsd:string [Term] id: UBERON:0009537 name: vascular element of right lung def: "A vascular plexus that is part of a right lung." [OBOL:automatic] subset: emapa_ehdaa2 xref: EHDAA2:0001757 xref: EMAPA:17668 is_a: UBERON:0000102 ! lung vasculature is_a: UBERON:0005629 ! vascular plexus intersection_of: UBERON:0005629 ! vascular plexus intersection_of: BFO:0000050 UBERON:0002167 ! part of right lung relationship: BFO:0000050 UBERON:0002167 ! part of right lung property_value: skos:prefLabel "vascular element of right lung" xsd:string [Term] id: UBERON:0009538 name: mesenchyme of sublingual gland primordium def: "Mesenchyme that is part of a sublingual gland primordium." [OBOL:automatic] subset: emapa_ehdaa2 xref: EHDAA2:0001937 xref: EMAPA:17754 is_a: BFO:0000002 is_a: UBERON:0003104 ! mesenchyme is_a: UBERON:0005291 ! embryonic tissue intersection_of: UBERON:0003104 ! mesenchyme intersection_of: BFO:0000050 UBERON:0006297 ! part of sublingual gland primordium relationship: BFO:0000050 UBERON:0006297 ! part of sublingual gland primordium relationship: RO:0002202 UBERON:0003324 ! develops from mesenchyme of lower jaw [Term] id: UBERON:0009539 name: mesenchyme of submandibular gland primordium def: "Mesenchyme that is part of a submandibular gland primordium." [OBOL:automatic] subset: emapa_ehdaa2 synonym: "submaxillary gland primordium mesenchyme" RELATED [EMAPA:17757] xref: EHDAA2:0001941 xref: EMAPA:17757 is_a: UBERON:0003324 ! mesenchyme of lower jaw is_a: UBERON:0005291 ! embryonic tissue intersection_of: UBERON:0003104 ! mesenchyme intersection_of: BFO:0000050 UBERON:0006298 ! part of submandibular gland primordium relationship: BFO:0000050 UBERON:0006298 ! part of submandibular gland primordium relationship: RO:0002202 UBERON:0003324 ! develops from mesenchyme of lower jaw [Term] id: UBERON:0009548 name: hepatic sinusoid of left lobe of liver def: "A hepatic sinusoid that is part of a left lobe of liver." [OBOL:automatic] subset: emapa_ehdaa2 synonym: "left lobe hepatic sinusoids" EXACT [VHOG:0000709] xref: EHDAA2:0001001 xref: EMAPA:18309 xref: VHOG:0000709 is_a: UBERON:0001281 ! hepatic sinusoid intersection_of: UBERON:0001281 ! hepatic sinusoid intersection_of: BFO:0000050 UBERON:0001115 ! part of left lobe of liver relationship: BFO:0000050 UBERON:0001115 ! part of left lobe of liver relationship: RO:0002226 UBERON:0001115 ! develops in left lobe of liver [Term] id: UBERON:0009549 name: hepatic sinusoid of right lobe of liver def: "A hepatic sinusoid that is part of a right lobe of liver." [OBOL:automatic] subset: emapa_ehdaa2 synonym: "right lobe hepatic sinusoids" EXACT [VHOG:0000710] xref: EHDAA2:0001009 xref: EMAPA:18316 xref: VHOG:0000710 is_a: UBERON:0001281 ! hepatic sinusoid intersection_of: UBERON:0001281 ! hepatic sinusoid intersection_of: BFO:0000050 UBERON:0001114 ! part of right lobe of liver relationship: BFO:0000050 UBERON:0001114 ! part of right lobe of liver relationship: RO:0002226 UBERON:0001114 ! develops in right lobe of liver [Term] id: UBERON:0009550 name: endoderm of foregut-midgut junction def: "An endoderm that is part of a foregut-midgut junction." [OBOL:automatic] subset: emapa_ehdaa2 xref: EHDAA2:0000572 xref: EMAPA:18403 is_a: UBERON:0000925 ! endoderm intersection_of: UBERON:0000925 ! endoderm intersection_of: BFO:0000050 UBERON:0006235 ! part of foregut-midgut junction relationship: BFO:0000050 UBERON:0006235 ! part of foregut-midgut junction property_value: skos:prefLabel "endoderm of foregut-midgut junction" xsd:string [Term] id: UBERON:0009551 name: distal segment of digit def: "A segment of a digit containing the distal phalanx, and overlapping the distal interphalangeal joint[CJM]. The digit tip is derived from multiple and distinct embryonic origins, and includes the distal bone with associated marrow cavity and haematopoietic cells, ventral (flexor) and dorsal (extensor) tendons, sweat glands with myoepithelial and luminal secreting cells and associated neurons for innervation, dermis with resident melanocytes and dendritic cells, mesenchyme with resident fibroblasts, skin epidermis with hair follicles, a nail organ composed of six specific parts (the root, nail bed, nail plate, eponychium (cuticle), perionychium and hyponychium)." [DOI:10.1038/nature10346] synonym: "digit tip" EXACT [https://orcid.org/0000-0002-6601-2165] synonym: "distal digit segment" EXACT [https://orcid.org/0000-0002-6601-2165] synonym: "tip of digit" EXACT [https://orcid.org/0000-0002-6601-2165] is_a: UBERON:0002529 ! limb segment intersection_of: UBERON:0002529 {source="cjm"} ! limb segment intersection_of: BFO:0000050 UBERON:0002544 {source="cjm"} ! part of digit intersection_of: BFO:0000051 UBERON:0004300 {source="cjm"} ! has part distal phalanx intersection_of: RO:0002131 UBERON:0009768 {source="cjm"} ! overlaps distal interphalangeal joint relationship: BFO:0000050 UBERON:0002544 ! part of digit relationship: BFO:0000051 UBERON:0004300 ! has part distal phalanx relationship: RO:0002131 UBERON:0009768 ! overlaps distal interphalangeal joint [Term] id: UBERON:0009552 name: distal segment of manual digit def: "A segment of the manual digit containing the distal phalanx." [http://orcid.org/0000-0002-6601-2165] subset: pheno_slim synonym: "finger digit tip" EXACT [DOI:10.1038/nature10346] synonym: "finger distal segment" EXACT [https://orcid.org/0000-0002-6601-2165] synonym: "finger tip" EXACT [https://orcid.org/0000-0002-6601-2165] synonym: "fingertip" EXACT [HP:0001211] synonym: "forelimb digit tip" EXACT [DOI:10.1038/nature10346] synonym: "tip of finger" EXACT [] xref: SCTID:312543003 is_a: UBERON:0005451 ! segment of manus is_a: UBERON:0009551 ! distal segment of digit intersection_of: UBERON:0009551 ! distal segment of digit intersection_of: BFO:0000050 UBERON:0002389 ! part of manual digit relationship: BFO:0000050 UBERON:0002389 ! part of manual digit [Term] id: UBERON:0009553 name: distal segment of pedal digit def: "A segment of the pedal digit containing the distal phalanx. Note this class represents a digit segment and thus includes tissues in addition to bone." [http://orcid.org/0000-0002-6601-2165] synonym: "distalmost part of toe" RELATED [https://orcid.org/0000-0002-6601-2165] synonym: "hindlimb digit tip" EXACT [DOI:10.1038/nature10346] synonym: "P3 segment of pedal digit" RELATED [https://orcid.org/0000-0002-6601-2165] synonym: "tip of toe" EXACT [https://orcid.org/0000-0002-6601-2165] synonym: "toe digit tip" EXACT [DOI:10.1038/nature10346] synonym: "toe distal segment" EXACT [https://orcid.org/0000-0002-6601-2165] is_a: UBERON:0005445 ! segment of pes is_a: UBERON:0009551 ! distal segment of digit intersection_of: UBERON:0009551 ! distal segment of digit intersection_of: BFO:0000050 UBERON:0001466 ! part of pedal digit relationship: BFO:0000050 UBERON:0001466 ! part of pedal digit [Term] id: UBERON:0009559 name: metacarpal/tarsal-phalangeal joint def: "A skeletal joint that connects a mesopodium bone and connects a proximal phalanx." [OBOL:automatic] synonym: "fetlock" NARROW SENSU [https://orcid.org/0000-0002-6601-2165, NCBITaxon:9788, Wikipedia:Fetlock] synonym: "metacarpo-tarsophalangeal joint" EXACT [https://orcid.org/0000-0002-6601-2165] synonym: "metapodial-phalangeal joint" EXACT [https://orcid.org/0000-0002-6601-2165] synonym: "metapodium-phalanx joint" EXACT [https://orcid.org/0000-0002-6601-2165] is_a: UBERON:0003841 ! autopod joint is_a: UBERON:0011139 ! synovial limb joint intersection_of: UBERON:0000982 ! skeletal joint intersection_of: RO:0002176 UBERON:0003656 ! connects mesopodium bone intersection_of: RO:0002176 UBERON:0004302 ! connects proximal phalanx relationship: BFO:0000050 UBERON:0002544 ! part of digit relationship: RO:0002176 UBERON:0003656 ! connects mesopodium bone relationship: RO:0002176 UBERON:0004302 ! connects proximal phalanx property_value: IAO:0000116 "We include these joints as being part of the digits; this is consistent with the FMA, and makes classification easier. Note that digit and metapodial regions are part-disjoint" xsd:string [Term] id: UBERON:0009564 name: distal limb integumentary appendage def: "A nail, hoof or claw." [PMID:11710767] synonym: "hoof or claw" RELATED [] synonym: "hoof, claw or nail" RELATED [] synonym: "keratin plate" RELATED [] synonym: "keratin sheath" RELATED [] synonym: "unguis" RELATED [] xref: MESH:D006724 is_a: BFO:0000002 is_a: UBERON:0013703 ! integumentary projection relationship: BFO:0000050 UBERON:0001003 ! part of skin epidermis relationship: BFO:0000050 UBERON:0009551 {source="cjm"} ! part of distal segment of digit relationship: RO:0002202 UBERON:0011272 {source="Wikipathways:WP2062"} ! develops from embryonic skin basal layer [Term] id: UBERON:0009565 name: nail of manual digit def: "A nail that is part of a manual digit." [OBOL:automatic] subset: pheno_slim synonym: "claw of hand" NARROW SENSU [] synonym: "claw of manus" NARROW SENSU [] synonym: "finger nail" EXACT [FMA:54327] synonym: "fingernail" EXACT [FMA:54327] synonym: "forelimb digit claw" NARROW SENSU [EMAPA:35349] synonym: "manual claw" NARROW SENSU [] synonym: "nail of finger" EXACT [FMA:54327] synonym: "nail plate of finger" RELATED [FMA:54327] xref: EMAPA:35349 xref: FMA:54327 xref: NCIT:C32609 xref: SCTID:244197001 xref: UMLS:C0222001 {source="ncithesaurus:Fingernail"} is_a: UBERON:0001705 ! nail intersection_of: UBERON:0001705 ! nail intersection_of: BFO:0000050 UBERON:0002389 ! part of manual digit relationship: BFO:0000050 UBERON:0005276 {source="FMA"} ! part of dorsal skin of finger relationship: BFO:0000050 UBERON:0009552 {source="https://github.com/obophenotype/uberon/wiki/Inferring-part-of-relationships"} ! part of distal segment of manual digit [Term] id: UBERON:0009566 name: intestinal submucosa def: "A submucosa that is part of a intestine." [OBOL:automatic] synonym: "submucosa of intestine" EXACT [FMA:15696] xref: FMA:15696 is_a: UBERON:0018257 ! submucosa of digestive tract intersection_of: UBERON:0000009 ! submucosa intersection_of: BFO:0000050 UBERON:0000160 ! part of intestine relationship: BFO:0000050 UBERON:0001262 {source="FMA"} ! part of wall of intestine property_value: skos:prefLabel "intestinal submucosa" xsd:string [Term] id: UBERON:0009567 name: nail of pedal digit def: "A nail that is part of a pedal digit." [OBOL:automatic] subset: pheno_slim synonym: "claw of foot" NARROW SENSU [] synonym: "claw of pes" NARROW SENSU [] synonym: "claw of toe" NARROW SENSU [] synonym: "hindlimb claw" NARROW SENSU [EMAPA:36457] synonym: "hindlimb digit claw" NARROW SENSU [] synonym: "nail of pes" EXACT [] synonym: "nail of toe" EXACT [FMA:54328] synonym: "nail plate of toe" RELATED [FMA:54328] synonym: "pedal claw" NARROW SENSU [] synonym: "toe nail" EXACT [FMA:54328] synonym: "toenail" EXACT [FMA:54328] xref: EMAPA:36457 xref: FMA:54328 xref: NCIT:C33790 xref: SCTID:244198006 xref: UMLS:C0222007 {source="ncithesaurus:Toe_Nail"} xref: XAO:0003103 is_a: UBERON:0001705 ! nail intersection_of: UBERON:0001705 ! nail intersection_of: BFO:0000050 UBERON:0001466 ! part of pedal digit relationship: BFO:0000050 UBERON:0005277 {source="FMA"} ! part of dorsal skin of toe relationship: BFO:0000050 UBERON:0009553 {source="https://github.com/obophenotype/uberon/wiki/Inferring-part-of-relationships"} ! part of distal segment of pedal digit [Term] id: UBERON:0009568 name: trunk region of vertebral column def: "Subdivision of vertebral column that corresponds to the trunk of the body, containing the trunk/presacral vertebrae. In organisms that have a thoracic and lumbar distinction, this corresponds to the sum of both of these regions." [UBERONREF:0000006] subset: pheno_slim synonym: "presacral region" RELATED [AAO:0000612] synonym: "thoracolumbar column" EXACT [] synonym: "thoracolumbar region" RELATED [AAO:0000612] synonym: "thoracolumbar region of vertebral column" EXACT [] synonym: "thoracolumbar vertebrae set" EXACT [FMA:72066] synonym: "thoracolumbar vertebral column" EXACT [] synonym: "trunk region" RELATED [AAO:0000612] synonym: "trunk skeleton" RELATED [] synonym: "trunk spine" RELATED [] synonym: "trunk vertebrae series" EXACT [] synonym: "trunk vertebral column" EXACT [] xref: FMA:72066 xref: NCIT:C92597 xref: SCTID:281699004 is_a: UBERON:0006077 ! subdivision of vertebral column intersection_of: UBERON:0006077 ! subdivision of vertebral column intersection_of: BFO:0000050 UBERON:0002100 ! part of trunk intersection_of: subdivision_of UBERON:0002100 ! trunk relationship: BFO:0000050 UBERON:0002100 ! part of trunk relationship: subdivision_of UBERON:0002100 ! trunk property_value: skos:prefLabel "trunk region of vertebral column" xsd:string [Term] id: UBERON:0009569 name: subdivision of trunk subset: non_informative synonym: "region of trunk" EXACT [FMA:25054] synonym: "trunk subdivision" EXACT [FMA:25054] xref: FMA:25054 xref: SCTID:22943007 is_a: UBERON:0000475 ! organism subdivision relationship: BFO:0000050 UBERON:0002100 ! part of trunk property_value: skos:prefLabel "subdivision of trunk" xsd:string [Term] id: UBERON:0009570 name: spinal cord sulcus limitans def: "A sulcus limitans of neural tube that is part of a future spinal cord." [OBOL:automatic] synonym: "spinal cord lateral wall sulcus limitans" EXACT [EHDAA2:0001265] xref: EHDAA2:0001265 xref: EMAPA:17584 xref: VHOG:0001548 is_a: UBERON:0005478 ! sulcus limitans of neural tube intersection_of: UBERON:0005478 ! sulcus limitans of neural tube intersection_of: BFO:0000050 UBERON:0006241 ! part of future spinal cord relationship: BFO:0000050 UBERON:0006241 ! part of future spinal cord property_value: skos:prefLabel "spinal cord sulcus limitans" xsd:string [Term] id: UBERON:0009571 name: ventral midline def: "In protostomes (such as insects, snails and worms) as well as deuterostomes (vertebrates), the midline is an embryonic region that functions in patterning of the adjacent nervous tissue. The ventral midline in insects is a cell population extending along the ventral surface of the embryo and is the region from which cells detach to form the ventrally located nerve cords. In vertebrates, the midline is originally located dorsally. During development, it folds inwards and becomes the ventral part of the dorsally located neural tube and is then called the ventral midline, or floor plate." [GOC:bf, GOC:go_curators, PMID:12075342] xref: FBbt:00000093 {sssom:mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"} is_a: UBERON:0002050 {source="FMA"} ! embryonic structure relationship: BFO:0000050 UBERON:0001016 ! part of nervous system relationship: RO:0002162 NCBITaxon:33213 ! in taxon Bilateria [Term] id: UBERON:0009572 name: lumen of central canal of spinal cord def: "A cerebrospinal fluid-filled space that runs longitudinally through the length of the entire spinal cord. The central canal is contiguous with the ventricular system of the brain. The central canal represents the adult remainder of the neural tube." [Wikipedia:Central_canal] synonym: "cavity of central canal of spinal cord" EXACT [FMA:242845] synonym: "central canal lumen" EXACT [https://orcid.org/0000-0002-6601-2165] synonym: "neural lumen" RELATED [] synonym: "spinal cord lumen" EXACT [EMAPA:25042] xref: EMAPA:25042 xref: FMA:242845 xref: Wikipedia:Central_canal is_a: BFO:0000002 is_a: UBERON:0000464 ! anatomical space intersection_of: UBERON:0000464 ! anatomical space intersection_of: RO:0002572 UBERON:0002291 ! luminal space of central canal of spinal cord relationship: RO:0002221 UBERON:0001359 ! surrounds cerebrospinal fluid relationship: RO:0002494 UBERON:0003842 ! transformation of neural tube lumen relationship: RO:0002572 UBERON:0002291 ! luminal space of central canal of spinal cord property_value: skos:prefLabel "lumen of central canal of spinal cord" xsd:string [Term] id: UBERON:0009576 name: medulla oblongata sulcus limitans def: "A sulcus limitans of neural tube that is part of a future medulla oblongata." [OBOL:automatic] xref: EHDAA2:0001100 xref: EMAPA:17561 is_a: BFO:0000002 is_a: UBERON:0005478 ! sulcus limitans of neural tube intersection_of: UBERON:0005478 ! sulcus limitans of neural tube intersection_of: BFO:0000050 UBERON:0001896 ! part of medulla oblongata relationship: BFO:0000050 UBERON:0001896 ! part of medulla oblongata relationship: RO:0002202 UBERON:0009578 {source="EHDAA2"} ! develops from myelencephalon sulcus limitans property_value: skos:prefLabel "medulla oblongata sulcus limitans" xsd:string [Term] id: UBERON:0009577 name: metencephalon sulcus limitans def: "A sulcus limitans of neural tube that is part of a future metencephalon." [OBOL:automatic] xref: EHDAA2:0001161 xref: EMAPA:17567 is_a: UBERON:0005478 ! sulcus limitans of neural tube intersection_of: UBERON:0005478 ! sulcus limitans of neural tube intersection_of: BFO:0000050 UBERON:0010092 ! part of future metencephalon relationship: BFO:0000050 UBERON:0010092 ! part of future metencephalon property_value: skos:prefLabel "metencephalon sulcus limitans" xsd:string [Term] id: UBERON:0009578 name: myelencephalon sulcus limitans def: "A sulcus limitans of neural tube that is part of a future myelencephalon." [OBOL:automatic] xref: EHDAA2:0001945 is_a: UBERON:0005478 ! sulcus limitans of neural tube intersection_of: UBERON:0005478 ! sulcus limitans of neural tube intersection_of: BFO:0000050 UBERON:0010096 ! part of future myelencephalon relationship: BFO:0000050 UBERON:0010096 ! part of future myelencephalon property_value: skos:prefLabel "myelencephalon sulcus limitans" xsd:string [Term] id: UBERON:0009580 name: diencephalon mantle layer synonym: "diencephalon lateral wall mantle layer" EXACT [] synonym: "mantle layer lateral wall diencephalon" EXACT [VHOG:0000912] xref: EHDAA2:0000397 xref: EMAPA:16906 xref: VHOG:0000912 is_a: UBERON:0004061 ! neural tube mantle layer intersection_of: UBERON:0004061 ! neural tube mantle layer intersection_of: BFO:0000050 UBERON:0006222 ! part of future diencephalon relationship: BFO:0000050 UBERON:0006222 ! part of future diencephalon property_value: skos:prefLabel "diencephalon mantle layer" xsd:string [Term] id: UBERON:0009581 name: midbrain mantle layer synonym: "mantle layer lateral wall mesencephalon" RELATED [VHOG:0000910] synonym: "mantle layer lateral wall midbrain" EXACT [VHOG:0000910] synonym: "midbrain lateral wall mantle layer" EXACT [] xref: EHDAA2:0001172 xref: EMAPA:16977 xref: VHOG:0000910 is_a: UBERON:0004061 ! neural tube mantle layer intersection_of: UBERON:0004061 ! neural tube mantle layer intersection_of: BFO:0000050 UBERON:0009616 ! part of presumptive midbrain relationship: BFO:0000050 UBERON:0009616 ! part of presumptive midbrain property_value: skos:prefLabel "midbrain mantle layer" xsd:string [Term] id: UBERON:0009583 name: spinal cord mantle layer synonym: "mantle layer lateral wall spinal cord" EXACT [VHOG:0000911] synonym: "spinal cord lateral wall mantle layer" EXACT [] xref: EMAPA:17580 xref: VHOG:0000911 is_a: UBERON:0004061 ! neural tube mantle layer intersection_of: UBERON:0004061 ! neural tube mantle layer intersection_of: BFO:0000050 UBERON:0006241 ! part of future spinal cord relationship: BFO:0000050 UBERON:0006241 ! part of future spinal cord property_value: skos:prefLabel "spinal cord mantle layer" xsd:string [Term] id: UBERON:0009584 name: 1st arch mandibular mesenchyme def: "Mesenchyme that is part of a 1st arch mandibular component." [OBOL:automatic] synonym: "mandibular component mesenchyme" RELATED [] synonym: "mandibular mesenchyme" RELATED [] synonym: "mesenchymal region of mandibular component of first pharyngeal arch" EXACT [https://orcid.org/0000-0002-6601-2165] synonym: "mesenchyme of mandibular component" EXACT [EMAPA:16385] xref: EHDAA2:0000034 xref: EMAPA:16385 is_a: UBERON:0010042 ! 1st arch mesenchyme intersection_of: UBERON:0003104 ! mesenchyme intersection_of: BFO:0000050 UBERON:0007237 ! part of 1st arch mandibular component relationship: BFO:0000050 UBERON:0007237 {source="EMAPA"} ! part of 1st arch mandibular component property_value: skos:prefLabel "1st arch mandibular mesenchyme" xsd:string [Term] id: UBERON:0009602 name: left lung associated mesenchyme def: "Mesenchyme that is part of a developing left lung." [OBOL:automatic] synonym: "left lung mesenchyme" EXACT [EMAPA:17654] xref: EHDAA2:0000944 xref: EMAPA:16730 xref: EMAPA:17654 is_a: UBERON:0004883 ! lung mesenchyme intersection_of: UBERON:0003104 ! mesenchyme intersection_of: BFO:0000050 UBERON:0002168 ! part of left lung relationship: BFO:0000050 UBERON:0002168 ! part of left lung property_value: skos:prefLabel "left lung associated mesenchyme" xsd:string [Term] id: UBERON:0009603 name: right lung associated mesenchyme def: "Mesenchyme that is part of a developing right lung." [OBOL:automatic] synonym: "right lung mesenchyme" EXACT [EMAPA:17662] xref: EHDAA2:0001739 xref: EMAPA:17662 is_a: UBERON:0004883 ! lung mesenchyme intersection_of: UBERON:0003104 ! mesenchyme intersection_of: BFO:0000050 UBERON:0002167 ! part of right lung relationship: BFO:0000050 UBERON:0002167 ! part of right lung property_value: skos:prefLabel "right lung associated mesenchyme" xsd:string [Term] id: UBERON:0009610 name: forebrain neural plate def: "A neural plate that develops_from a future forebrain." [OBOL:automatic] xref: TAO:0007018 xref: ZFA:0007018 is_a: UBERON:0003075 ! neural plate intersection_of: UBERON:0003075 {source="ZFA"} ! neural plate intersection_of: RO:0002202 UBERON:0006240 {source="ZFA"} ! develops from future forebrain relationship: BFO:0000050 UBERON:0003056 {source="ZFA"} ! part of pre-chordal neural plate relationship: RO:0002202 UBERON:0006240 ! develops from future forebrain property_value: skos:prefLabel "forebrain neural plate" xsd:string [Term] id: UBERON:0009611 name: midbrain neural plate def: "A neural plate that develops_from a presumptive midbrain." [OBOL:automatic] xref: TAO:0007019 xref: ZFA:0007019 is_a: UBERON:0003075 ! neural plate intersection_of: UBERON:0003075 {source="ZFA"} ! neural plate intersection_of: RO:0002202 UBERON:0009616 {source="ZFA"} ! develops from presumptive midbrain relationship: BFO:0000050 UBERON:0003056 {source="ZFA"} ! part of pre-chordal neural plate relationship: RO:0002202 UBERON:0009616 ! develops from presumptive midbrain property_value: skos:prefLabel "midbrain neural plate" xsd:string [Term] id: UBERON:0009614 name: hindbrain neural plate def: "A neural plate that develops_from a presumptive hindbrain." [OBOL:automatic] xref: TAO:0007022 xref: ZFA:0007022 is_a: UBERON:0003075 ! neural plate intersection_of: UBERON:0003075 {source="ZFA"} ! neural plate intersection_of: RO:0002202 UBERON:0007277 {source="ZFA"} ! develops from presumptive hindbrain relationship: BFO:0000050 UBERON:0003057 {source="ZFA"} ! part of chordal neural plate relationship: RO:0002202 UBERON:0007277 ! develops from presumptive hindbrain property_value: skos:prefLabel "hindbrain neural plate" xsd:string [Term] id: UBERON:0009615 name: midbrain hindbrain boundary neural plate synonym: "MHB neural plate" EXACT [https://orcid.org/0000-0002-6601-2165] synonym: "midbrain-hindbrain boundary neural plate" EXACT [ZFA:0007044] xref: TAO:0007044 xref: ZFA:0007044 is_a: UBERON:0004121 ! ectoderm-derived structure is_a: UBERON:0006598 ! presumptive structure relationship: BFO:0000050 UBERON:0003075 {source="ZFA"} ! part of neural plate relationship: RO:0002495 UBERON:0007281 ! immediate transformation of presumptive midbrain hindbrain boundary property_value: IAO:0000116 "TODO - developmental relationships for lines" xsd:string property_value: skos:prefLabel "midbrain hindbrain boundary neural plate" xsd:string [Term] id: UBERON:0009616 name: presumptive midbrain def: "A presumptive structure that has the potential to develop into a midbrain." [OBOL:automatic] subset: efo_slim synonym: "early midbrain" RELATED [https://orcid.org/0000-0002-6601-2165] synonym: "future midbrain" RELATED [https://orcid.org/0000-0002-6601-2165] synonym: "mesencephalon" RELATED [EHDAA2:0000615] synonym: "presumptive mesencephalon" EXACT [ZFA:0000148] xref: BAMS:MES xref: EFO:0003432 xref: EHDAA2:0000615 xref: EMAPA:16140 xref: TAO:0000148 xref: Wikipedia:Mesencephalon xref: ZFA:0000148 is_a: BFO:0000002 is_a: UBERON:0006598 ! presumptive structure intersection_of: UBERON:0006598 ! presumptive structure intersection_of: RO:0002387 UBERON:0001891 ! has potential to develop into midbrain relationship: BFO:0000050 UBERON:0006238 {source="ZFA"} ! part of future brain relationship: RO:0002202 UBERON:0003080 ! develops from anterior neural tube relationship: RO:0002202 UBERON:0010286 {source="ZFA"} ! develops from midbrain neural tube relationship: RO:0002387 UBERON:0001891 ! has potential to develop into midbrain property_value: IAO:0000116 "TODO - unify naming conventions" xsd:string property_value: skos:prefLabel "presumptive midbrain" xsd:string [Term] id: UBERON:0009617 name: head paraxial mesoderm def: "Bilateral mesenchymal mesoderm parallel and immediately adjacent to the neural tube/notochord; it generates a subset of extra-ocular, and other head, muscles." [PMID:21610022] synonym: "cephalic paraxial mesenchyme" EXACT [https://orcid.org/0000-0002-6601-2165] synonym: "cephalic paraxial mesoderm" EXACT [https://orcid.org/0000-0002-6601-2165] synonym: "cranial paraxial mesenchyme" EXACT [https://orcid.org/0000-0002-6601-2165] synonym: "cranial paraxial mesoderm" EXACT [https://orcid.org/0000-0002-6601-2165] synonym: "head paraxial mesenchyme" EXACT [EHDAA2:0000736, https://github.com/obophenotype/uberon/issues/30] synonym: "somitomere" RELATED [] synonym: "somitomeric mesoderm" RELATED [] xref: EHDAA2:0000736 xref: EHDAA:364 xref: EMAPA:16171 is_a: UBERON:0005253 ! head mesenchyme relationship: BFO:0000050 UBERON:0003077 ! part of paraxial mesoderm relationship: BFO:0000050 UBERON:0005253 {source="EHDAA2"} ! part of head mesenchyme property_value: skos:prefLabel "head paraxial mesoderm" xsd:string [Term] id: UBERON:0009618 name: trunk paraxial mesoderm synonym: "trunk and cervical paraxial mesenchyme" EXACT [EHDAA2:0002094] synonym: "trunk paraxial mesenchyme" RELATED [https://github.com/obophenotype/uberon/issues/30] xref: EHDAA2:0002094 is_a: UBERON:0005256 ! trunk mesenchyme relationship: BFO:0000050 UBERON:0003077 ! part of paraxial mesoderm relationship: BFO:0000050 UBERON:0005256 {source="EHDAA2"} ! part of trunk mesenchyme property_value: skos:prefLabel "trunk paraxial mesoderm" xsd:string [Term] id: UBERON:0009621 name: tail somite def: "A somite that is part of a tail." [OBOL:automatic] xref: AAO:0010383 xref: EMAPA:16860 xref: XAO:0003143 is_a: UBERON:0002329 ! somite intersection_of: UBERON:0002329 ! somite intersection_of: BFO:0000050 UBERON:0002415 ! part of tail relationship: BFO:0000050 UBERON:0002415 ! part of tail property_value: skos:prefLabel "tail somite" xsd:string [Term] id: UBERON:0009622 name: pronephric proximal straight tubule def: "A proximal straight tubule that is part of a pronephros." [ZFIN:ZDB-PUB-071029-9] synonym: "proximal straight tubules" RELATED OMO:0003004 [TAO:0002239] xref: TAO:0002239 xref: ZFA:0001621 is_a: UBERON:0001290 ! proximal straight tubule is_a: UBERON:0005310 ! pronephric nephron tubule intersection_of: UBERON:0001290 ! proximal straight tubule intersection_of: BFO:0000050 UBERON:0002120 ! part of pronephros relationship: BFO:0000050 UBERON:0006173 {is_inferred="true", source="https://github.com/obophenotype/uberon/wiki/Inferring-part-of-relationships"} ! part of pronephric proximal tubule [Term] id: UBERON:0009623 name: spinal nerve root def: "The paired bundles of nerve fibers entering and leaving the spinal cord at each segment. The dorsal and ventral nerve roots join to form the mixed segmental spinal nerves. The dorsal roots are generally afferent, formed by the central projections of the spinal (dorsal root) ganglia sensory cells, and the ventral roots efferent, comprising the axons of spinal motor and autonomic preganglionic neurons. There are, however, some exceptions to this afferent/efferent rule." [MESH:A08.800.800.720.725] subset: human_reference_atlas synonym: "root of spinal nerve" EXACT [FMA:14060] synonym: "spinal neural root" EXACT [FMA:14060] synonym: "spinal root" EXACT [BTO:0000883] xref: BTO:0000883 xref: DHBA:146035120 xref: FMA:14060 xref: GAID:717 xref: MESH:D013126 xref: NCIT:C12791 xref: UMLS:C0037940 {source="ncithesaurus:Spinal_Nerve_Root"} xref: ZFA:0005578 is_a: UBERON:0002211 {source="FMA"} ! nerve root intersection_of: UBERON:0002211 ! nerve root intersection_of: extends_fibers_into UBERON:0001780 ! spinal nerve intersection_of: extends_fibers_into UBERON:0002240 ! spinal cord relationship: extends_fibers_into UBERON:0001780 ! spinal nerve relationship: extends_fibers_into UBERON:0002240 ! spinal cord relationship: RO:0002433 UBERON:0001780 ! contributes to morphology of spinal nerve relationship: RO:0002433 UBERON:0002240 ! contributes to morphology of spinal cord property_value: RO:0002175 NCBITaxon:9606 property_value: seeAlso "https://github.com/obophenotype/uberon/issues/2644" xsd:string property_value: skos:prefLabel "spinal nerve root" xsd:string [Term] id: UBERON:0009624 name: lumbar nerve def: "The lumbar nerves are the five spinal nerves emerging from the lumbar vertebrae. They are divided into posterior and anterior divisions." [Wikipedia:Lumbar_nerves] subset: human_reference_atlas synonym: "lumbar spinal nerve" EXACT [FMA:5861] synonym: "nervi lumbales" RELATED OMO:0003011 [Wikipedia:Lumbar_nerves] synonym: "nervus lumbalis" EXACT OMO:0003011 [FMA:5861, FMA:TA] xref: FMA:5861 xref: NCIT:C33015 xref: neuronames:1730 xref: SCTID:361600002 xref: UMLS:C0228897 {source="ncithesaurus:Lumbar_Nerve"} xref: Wikipedia:Lumbar_nerves is_a: UBERON:0001780 ! spinal nerve intersection_of: UBERON:0001780 ! spinal nerve intersection_of: extends_fibers_into UBERON:0002792 ! lumbar spinal cord relationship: extends_fibers_into UBERON:0002792 ! lumbar spinal cord property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/d/d1/Gray802.png" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0009625 name: sacral nerve def: "The five sacral nerves emerge from the sacrum. Although the vertebral components of the sacrum are fused into a single bone, the sacral vertebrae are still used to number the sacral nerves. Posteriorly, they emerge from the posterior sacral foramina, and form the posterior branches of sacral nerves. Anteriorly, they emerge from the anterior sacral foramina, and contribute to the sacral plexus (S1-S4) and coccygeal plexus." [Wikipedia:Sacral_nerves] subset: human_reference_atlas synonym: "nervi sacrales" RELATED OMO:0003011 [Wikipedia:Sacral_nerves] synonym: "nervus sacralis" EXACT OMO:0003011 [FMA:5862, FMA:TA] synonym: "sacral spinal nerve" EXACT [FMA:5862] xref: FMA:5862 xref: NCIT:C33505 xref: neuronames:1720 xref: SCTID:361601003 xref: UMLS:C0228922 {source="ncithesaurus:Sacral_Nerve"} xref: Wikipedia:Sacral_nerves is_a: UBERON:0001780 ! spinal nerve intersection_of: UBERON:0001780 ! spinal nerve intersection_of: extends_fibers_into UBERON:0005843 ! sacral spinal cord relationship: extends_fibers_into UBERON:0005843 ! sacral spinal cord property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/d/d1/Gray802.png" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0009630 name: root of thoracic nerve def: "A spinal nerve root that is part of a thoracic nerve." [OBOL:automatic] synonym: "nerve root part of thoracic spinal cord" EXACT [NIF:NIF] synonym: "thoracic nerve root" EXACT [FMA:14064] synonym: "thoracic neural root" EXACT [FMA:14064] xref: BIRNLEX:836 xref: FMA:14064 is_a: UBERON:0009623 ! spinal nerve root intersection_of: UBERON:0009623 ! spinal nerve root intersection_of: extends_fibers_into UBERON:0003726 ! thoracic nerve relationship: extends_fibers_into UBERON:0003726 ! thoracic nerve property_value: skos:prefLabel "root of thoracic nerve" xsd:string [Term] id: UBERON:0009631 name: root of lumbar spinal nerve def: "A spinal nerve root that is part of a lumbar nerve." [OBOL:automatic] synonym: "lumbar spinal nerve root" EXACT [FMA:16421] synonym: "lumbar spinal neural root" EXACT [FMA:16421] synonym: "nerve root part of lumbar spinal cord" EXACT [NIF:NIF] xref: BIRNLEX:1613 xref: FMA:16421 xref: NCIT:C12924 xref: SCTID:180968005 xref: UMLS:C0581666 {source="ncithesaurus:Lumbar_Spinal_Nerve_Root"} is_a: UBERON:0009623 ! spinal nerve root intersection_of: UBERON:0009623 ! spinal nerve root intersection_of: extends_fibers_into UBERON:0009624 ! lumbar nerve relationship: extends_fibers_into UBERON:0009624 ! lumbar nerve [Term] id: UBERON:0009632 name: root of cervical nerve synonym: "cervical neural root" EXACT [FMA:16422] synonym: "cervical spinal root" EXACT [FMA:16422] synonym: "nerve root part of cervical spinal cord" EXACT [NIF:NIF] synonym: "root of cervical spinal nerve" EXACT [FMA:16422] xref: BIRNLEX:955 xref: FMA:16422 xref: NCIT:C12893 xref: SCTID:180966009 xref: UMLS:C0581631 {source="ncithesaurus:Cervical_Spinal_Nerve_Root"} is_a: UBERON:0009623 ! spinal nerve root intersection_of: UBERON:0009623 ! spinal nerve root intersection_of: extends_fibers_into UBERON:0000962 ! nerve of cervical vertebra relationship: extends_fibers_into UBERON:0000962 ! nerve of cervical vertebra property_value: skos:prefLabel "root of cervical nerve" xsd:string [Term] id: UBERON:0009633 name: root of sacral nerve def: "A spinal nerve root that is part of a sacral nerve." [OBOL:automatic] synonym: "nerve root part of sacral spinal cord" EXACT [NIF:NIF] synonym: "root of sacral spinal nerve" EXACT [FMA:18028] synonym: "sacral neural root" EXACT [FMA:18028] xref: BIRNLEX:1518 xref: FMA:18028 xref: NCIT:C12925 xref: SCTID:244454000 xref: UMLS:C0581672 {source="ncithesaurus:Sacral_Spinal_Nerve_Root"} is_a: UBERON:0009623 ! spinal nerve root intersection_of: UBERON:0009623 ! spinal nerve root intersection_of: extends_fibers_into UBERON:0009625 ! sacral nerve disjoint_from: UBERON:0029503 {source="NIFSTD"} ! sacral spinal cord gray matter relationship: extends_fibers_into UBERON:0009625 ! sacral nerve [Term] id: UBERON:0009638 name: orbitosphenoid ossification center comment: merge with sphenoid lesser wing cartilage element? synonym: "orbitosphenoid center" RELATED [] is_a: UBERON:0010355 ! ossification center property_value: skos:prefLabel "orbitosphenoid ossification center" xsd:string [Term] id: UBERON:0009644 name: trachea non-cartilage connective tissue subset: human_reference_atlas xref: EMAPA:35878 xref: MA:0001859 is_a: UBERON:0003571 {source="MA"} ! trachea connective tissue property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "trachea non-cartilage connective tissue" xsd:string [Term] id: UBERON:0009646 name: lumbar sympathetic nerve trunk def: "A sympathetic nerve trunk that is part of a lower back." [OBOL:automatic] synonym: "lumbar part of sympathetic trunk" RELATED [FMA:6263] synonym: "lumbar sympathetic chain" RELATED [FMA:6263] synonym: "lumbar sympathetic trunk" EXACT [FMA:6263] xref: EMAPA:37655 {source="MA:th"} xref: FMA:6263 xref: MA:0001163 xref: NCIT:C52828 xref: SCTID:280534006 xref: UMLS:C1708762 {source="ncithesaurus:Lumbar_Sympathetic_Nerve_Trunk"} is_a: UBERON:0004295 ! sympathetic nerve trunk intersection_of: UBERON:0004295 ! sympathetic nerve trunk intersection_of: BFO:0000050 UBERON:0005462 ! part of lower back relationship: BFO:0000050 UBERON:0005462 ! part of lower back [Term] id: UBERON:0009647 name: tympanic membrane epithelium def: "One of the two epithelia which make up the tympanic membrane (along with the fibrous layer)." [https://orcid.org/0000-0002-6601-2165, PMID:11237469] synonym: "tympanic epithelium" EXACT [MA:0001224] synonym: "tympanic membrane epithelial layer" EXACT [] xref: EMAPA:19064 xref: MA:0001224 xref: NCIT:C49308 xref: SCTID:70839004 xref: UMLS:C1711401 {source="ncithesaurus:Tympanic_Epithelium"} is_a: UBERON:0010071 ! layer of tympanic membrane is_a: UBERON:0015813 ! middle ear epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: BFO:0000050 UBERON:0002364 ! part of tympanic membrane disjoint_from: UBERON:0010070 ! intermediate layer of tympanic membrane [Term] id: UBERON:0009648 name: eyelid subcutaneous connective tissue def: "An eyelid connective tissue that is part of a hypodermis." [OBOL:automatic] synonym: "superficial fascia of eyelid" RELATED [FMA:63975] xref: EMAPA:37533 {source="MA:th"} xref: FMA:63975 xref: MA:0001252 xref: NCIT:C49226 xref: UMLS:C1707991 {source="ncithesaurus:Eyelid_Subcutaneous_Connective_Tissue"} is_a: UBERON:0003581 ! eyelid connective tissue intersection_of: UBERON:0003581 ! eyelid connective tissue intersection_of: BFO:0000050 UBERON:0002072 ! part of hypodermis relationship: BFO:0000050 UBERON:0002072 ! part of hypodermis relationship: RO:0002220 UBERON:0001457 ! adjacent to skin of eyelid [Term] id: UBERON:0009651 name: nephron tubule basement membrane def: "A basement membrane that is part of a nephron tubule." [OBOL:automatic] synonym: "kidney tubule basement membrane" EXACT [MA:0001680] synonym: "renal tubular basement membrane" EXACT [] synonym: "renal tubule basement membrane" EXACT [MA:0001680] xref: EMAPA:37490 {source="MA:th"} xref: MA:0001680 xref: NCIT:C49273 xref: SCTID:245251000 xref: UMLS:C1709901 {source="ncithesaurus:Renal_Tubule_Basement_Membrane"} is_a: UBERON:0005769 ! basement membrane of epithelium intersection_of: UBERON:0005769 ! basement membrane of epithelium intersection_of: BFO:0000050 UBERON:0001231 ! part of nephron tubule relationship: BFO:0000050 UBERON:0004810 {is_inferred="true", source="https://github.com/obophenotype/uberon/wiki/Inferring-part-of-relationships"} ! part of nephron tubule epithelium [Term] id: UBERON:0009652 name: bronchus basement membrane def: "A basement membrane that is part of a bronchus." [OBOL:automatic] synonym: "bronchial basement membrane" EXACT [http://orcid.org/0000-0002-6601-2165] xref: EMAPA:37809 {source="MA:th"} xref: MA:0001832 xref: NCIT:C49208 xref: UMLS:C1707051 {source="ncithesaurus:Bronchus_Basement_Membrane"} is_a: UBERON:0015329 ! respiratory system basement membrane intersection_of: UBERON:0005769 ! basement membrane of epithelium intersection_of: BFO:0000050 UBERON:0002185 ! part of bronchus relationship: BFO:0000050 UBERON:0002031 {is_inferred="true", source="https://github.com/obophenotype/uberon/wiki/Inferring-part-of-relationships"} ! part of epithelium of bronchus property_value: skos:prefLabel "bronchus basement membrane" xsd:string [Term] id: UBERON:0009653 name: trachea basement membrane def: "A basement membrane that is part of a trachea." [OBOL:automatic] xref: EMAPA:37552 {source="MA:th"} xref: MA:0001854 xref: NCIT:C49302 xref: UMLS:C1710455 {source="ncithesaurus:Trachea_Basement_Membrane"} is_a: UBERON:0015329 ! respiratory system basement membrane intersection_of: UBERON:0005769 ! basement membrane of epithelium intersection_of: BFO:0000050 UBERON:0003126 ! part of trachea relationship: BFO:0000050 UBERON:0001901 {is_inferred="true", source="https://github.com/obophenotype/uberon/wiki/Inferring-part-of-relationships"} ! part of epithelium of trachea relationship: BFO:0000050 UBERON:0009644 {source="MA-modified"} ! part of trachea non-cartilage connective tissue property_value: skos:prefLabel "trachea basement membrane" xsd:string [Term] id: UBERON:0009655 name: auricular artery def: "An artery that supplies oxygenated blood to the ear." [ncithesaurus:Auricular_Artery] xref: EMAPA:37072 {source="MA:th"} xref: MA:0001918 xref: NCIT:C52849 xref: UMLS:C1706858 {source="ncithesaurus:Auricular_Artery"} is_a: UBERON:0001637 ! artery intersection_of: UBERON:0001637 ! artery intersection_of: RO:0020101 UBERON:0001691 ! vessel supplies blood to external ear relationship: RO:0020101 UBERON:0001691 ! vessel supplies blood to external ear property_value: IAO:0000116 "add child terms" xsd:string [Term] id: UBERON:0009657 name: artery of lip synonym: "labial artery" BROAD [MA:0001987] xref: EMAPA:37092 {source="MA:th"} xref: MA:0001987 xref: NCIT:C52947 xref: UMLS:C1708633 {source="ncithesaurus:Labial_Artery"} is_a: UBERON:0001637 ! artery intersection_of: UBERON:0001637 ! artery intersection_of: RO:0020101 UBERON:0001833 ! vessel supplies blood to lip relationship: RO:0020101 UBERON:0001833 ! vessel supplies blood to lip property_value: skos:prefLabel "artery of lip" xsd:string [Term] id: UBERON:0009661 name: midbrain nucleus def: "Nucleus located in the midbrain." [ZFIN:curator] xref: SCTID:279285003 xref: TAO:0002209 xref: ZFA:0001665 is_a: UBERON:0002308 ! nucleus of brain intersection_of: UBERON:0002308 ! nucleus of brain intersection_of: BFO:0000050 UBERON:0001891 ! part of midbrain relationship: BFO:0000050 UBERON:0001891 ! part of midbrain property_value: skos:prefLabel "midbrain nucleus" xsd:string [Term] id: UBERON:0009662 name: hindbrain nucleus def: "Nucleus located within the hindbrain." [ZFIN:curator] xref: TAO:0002177 xref: ZFA:0001658 is_a: UBERON:0002308 ! nucleus of brain intersection_of: UBERON:0002308 ! nucleus of brain intersection_of: BFO:0000050 UBERON:0002028 ! part of hindbrain relationship: BFO:0000050 UBERON:0002028 ! part of hindbrain property_value: skos:prefLabel "hindbrain nucleus" xsd:string [Term] id: UBERON:0009663 name: telencephalic nucleus def: "A nucleus of brain that is part of a telencephalon." [OBOL:automatic] xref: TAO:0002178 xref: ZFA:0001660 is_a: UBERON:0002308 ! nucleus of brain intersection_of: UBERON:0002308 ! nucleus of brain intersection_of: BFO:0000050 UBERON:0001893 ! part of telencephalon relationship: BFO:0000050 UBERON:0001893 ! part of telencephalon property_value: skos:prefLabel "telencephalic nucleus" xsd:string [Term] id: UBERON:0009664 name: gut mesentery synonym: "peritoneal cavity mesentary" RELATED [http://orcid.org/0000-0002-6601-2165] synonym: "peritoneal mesentary" RELATED [http://orcid.org/0000-0002-6601-2165] xref: EHDAA2:0004566 xref: EMAPA:32911 xref: MA:0003203 is_a: UBERON:0002095 ! mesentery relationship: RO:0001025 UBERON:0001179 {source="EHDAA2"} ! located in peritoneal cavity property_value: seeAlso "https://github.com/obophenotype/uberon/issues/509" xsd:anyURI [Term] id: UBERON:0009668 name: ventral mesentery def: "Ventral mesentery is the part of the peritoneum closest to the navel." [Wikipedia:Ventral_mesentery] xref: EHDAA2:0004569 xref: SCTID:361430000 xref: Wikipedia:Ventral_mesentery is_a: UBERON:0002050 ! embryonic structure relationship: BFO:0000050 UBERON:0009664 {source="EHDAA2"} ! part of gut mesentery [Term] id: UBERON:0009669 name: embryonic cloacal lumen def: "An anatomical space that surrounded_by a embryonic cloaca." [OBOL:automatic] xref: EHDAA2:0004586 is_a: UBERON:0012463 ! cloacal lumen intersection_of: UBERON:0000464 ! anatomical space intersection_of: RO:0002572 UBERON:0000163 ! luminal space of embryonic cloaca relationship: RO:0002219 UBERON:0009846 ! surrounded by embryonic cloacal epithelium relationship: RO:0002572 UBERON:0000163 ! luminal space of embryonic cloaca property_value: skos:prefLabel "embryonic cloacal lumen" xsd:string [Term] id: UBERON:0009670 name: rectal lumen def: "An anatomical space that surrounded_by a rectum." [OBOL:automatic] synonym: "lumen of rectum" EXACT [FMA:14598] xref: EHDAA2:0004587 xref: EMAPA:18388 xref: FMA:14598 xref: SCTID:259740004 is_a: BFO:0000002 is_a: UBERON:0000464 ! anatomical space intersection_of: UBERON:0000464 ! anatomical space intersection_of: RO:0002572 UBERON:0001052 ! luminal space of rectum relationship: BFO:0000050 UBERON:0012465 {source="cjm"} ! part of lumen of terminal part of digestive tract relationship: RO:0002202 UBERON:0009669 {source="EHDAA2"} ! develops from embryonic cloacal lumen relationship: RO:0002572 UBERON:0001052 ! luminal space of rectum property_value: skos:prefLabel "rectal lumen" xsd:string [Term] id: UBERON:0009676 name: early telencephalic vesicle subset: efo_slim synonym: "early telencephalic ventricle" RELATED [] synonym: "early telencephalic vesicle" EXACT [EHDAA2:0001981] xref: EFO:0003562 xref: EHDAA2:0001981 xref: EHDAA:1993 xref: EHDAA:2671 xref: EMAPA:16914 is_a: BFO:0000002 is_a: UBERON:0013150 ! future brain vesicle relationship: BFO:0000050 UBERON:0001893 {source="EHDAA2"} ! part of telencephalon relationship: RO:0002202 UBERON:0006284 {source="EHDAA2"} ! develops from early prosencephalic vesicle property_value: skos:prefLabel "early telencephalic vesicle" xsd:string [Term] id: UBERON:0009678 name: tooth row def: "Anatomical cluster consisting of adjacent teeth constituting a row." [ZFIN:curator] synonym: "dental arcade" EXACT [FMA:59415] synonym: "row of teeth" EXACT [https://orcid.org/0000-0002-6601-2165] synonym: "tooth rows" EXACT OMO:0003004 [ZFA:0001642] xref: FMA:59415 xref: TAO:0001667 xref: ZFA:0001642 is_a: UBERON:0003672 ! dentition is_a: UBERON:0034926 ! anatomical row intersection_of: UBERON:0034926 ! anatomical row intersection_of: RO:0002351 UBERON:0001091 ! has member calcareous tooth property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/mouth-female/v1.0/assets/3d-vh-f-mouth.glb" xsd:anyURI [Term] id: UBERON:0009679 name: set of lower jaw teeth def: "A tooth row that is part of a skeleton of lower jaw." [OBOL:automatic] subset: pheno_slim synonym: "arcus dentalis inferior" EXACT OMO:0003011 [FMA:TA] synonym: "lower dental arcade" EXACT [FMA:55635] synonym: "lower jaw teeth" EXACT [EHDAA2:0001029] synonym: "mandibular dental arcade" RELATED [FMA:55635] synonym: "set of all lower teeth" EXACT [FMA:55635] xref: EHDAA2:0001029 xref: FMA:55635 is_a: UBERON:0009678 ! tooth row intersection_of: UBERON:0009678 ! tooth row intersection_of: BFO:0000050 UBERON:0003278 ! part of skeleton of lower jaw relationship: BFO:0000050 UBERON:0003278 ! part of skeleton of lower jaw property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/mouth-female/v1.0/assets/3d-vh-f-mouth.glb" xsd:anyURI [Term] id: UBERON:0009680 name: set of upper jaw teeth def: "A tooth row that is part of a skeleton of upper jaw." [OBOL:automatic] subset: pheno_slim synonym: "arcus dentalis superior" EXACT OMO:0003011 [FMA:TA] synonym: "maxillary dental arcade" RELATED [FMA:55634] synonym: "set of all upper teeth" EXACT [FMA:55634] synonym: "upper dental arcade" EXACT [FMA:55634] synonym: "upper jaw teeth" EXACT [EHDAA2:0002129] xref: EHDAA2:0002129 xref: FMA:55634 is_a: UBERON:0009678 ! tooth row intersection_of: UBERON:0009678 ! tooth row intersection_of: BFO:0000050 UBERON:0003277 ! part of skeleton of upper jaw relationship: BFO:0000050 UBERON:0003277 ! part of skeleton of upper jaw property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/mouth-female/v1.0/assets/3d-vh-f-mouth.glb" xsd:anyURI [Term] id: UBERON:0009692 name: lumen of pharyngotympanic tube def: "An organ cavity that is part of a pharyngotympanic tube." [OBOL:automatic] synonym: "auditory tube lumen" EXACT [EHDAA2:0004118] synonym: "lumen of auditory tube" EXACT [FMA:60079] synonym: "lumen of eustachian tube" EXACT [FMA:60079] synonym: "pharyngotympanic tube lumen" EXACT [FMA:60079] xref: EHDAA2:0004118 xref: FMA:60079 is_a: BFO:0000002 is_a: UBERON:0002558 ! organ cavity is_a: UBERON:0005082 {source="EHDAA2"} ! tube lumen intersection_of: UBERON:0002558 ! organ cavity intersection_of: BFO:0000050 UBERON:0002393 ! part of pharyngotympanic tube relationship: BFO:0000050 UBERON:0002393 ! part of pharyngotympanic tube relationship: RO:0002150 UBERON:0010060 ! continuous with pharyngeal opening of pharyngotympanic tube relationship: RO:0002219 UBERON:0010062 {source="cjm"} ! surrounded by pharyngotympanic tube epithelium relationship: RO:0002285 UBERON:0005625 {source="EHDAA2/Kardong"} ! developmentally replaces tubotympanic recess lumen property_value: IAO:0000116 "Check relationships for conformance with AAO and XAO" xsd:string [Term] id: UBERON:0009697 name: epithelium of appendix def: "An epithelium that is part of a vermiform appendix." [OBOL:automatic] synonym: "appendix epithelium" EXACT [FMA:63581] synonym: "epithelium of vermiform appendix" EXACT [FMA:63581] xref: CALOHA:TS-2062 xref: EHDAA2:0004561 xref: FMA:63581 is_a: BFO:0000002 is_a: UBERON:0001278 ! epithelium of large intestine intersection_of: UBERON:0000483 ! epithelium intersection_of: BFO:0000050 UBERON:0001154 ! part of vermiform appendix relationship: BFO:0000050 UBERON:0003929 {source="EHDAA2"} ! part of digestive tract epithelium relationship: BFO:0000050 UBERON:0004989 ! part of mucosa of appendix relationship: RO:0002202 UBERON:0005636 {source="EHDAA2"} ! develops from caecum epithelium [Term] id: UBERON:0009708 name: dorsal pancreas subset: human_reference_atlas subset: organ_slim synonym: "pancreatis dorsalis" RELATED [] xref: EHDAA2:0001371 is_a: BFO:0000002 is_a: UBERON:0002365 {source="EHDAA2"} ! exocrine gland is_a: UBERON:0005177 ! trunk region element relationship: BFO:0000050 UBERON:0001264 {source="EHDAA2"} ! part of pancreas relationship: RO:0002202 UBERON:0010375 {source="EHDAA2"} ! develops from pancreas dorsal primordium relationship: RO:0002254 UBERON:0003923 {source="cjm"} ! has developmental contribution from dorsal pancreatic bud property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "dorsal pancreas" xsd:string [Term] id: UBERON:0009709 name: ventral pancreas subset: human_reference_atlas subset: organ_slim synonym: "pancreatis ventralis" RELATED [] xref: EHDAA2:0001393 is_a: BFO:0000002 is_a: UBERON:0002365 {source="EHDAA2"} ! exocrine gland is_a: UBERON:0005177 ! trunk region element relationship: BFO:0000050 UBERON:0001264 {source="EHDAA2"} ! part of pancreas relationship: RO:0002202 UBERON:0010376 {source="EHDAA2"} ! develops from pancreas ventral primordium relationship: RO:0002254 UBERON:0003924 {source="cjm"} ! has developmental contribution from ventral pancreatic bud property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "ventral pancreas" xsd:string [Term] id: UBERON:0009712 name: endocardium of right ventricle def: "Any endocardium that is part of the right ventricle of the heart." [http://orcid.org/0000-0002-6601-2165] synonym: "endocardial lining of right ventricle" RELATED [EMAPA:17341] synonym: "right ventricle endocardial tissue" RELATED [VHOG:0001235] synonym: "right ventricle endocardium" EXACT [VHOG:0001235] synonym: "right ventricular endocardium" EXACT [FMA:9536] xref: EHDAA2:0002188 xref: EMAPA:17341 xref: FMA:9536 xref: NCIT:C102343 xref: SCTID:8911002 xref: VHOG:0001235 is_a: UBERON:0001081 ! endocardium of ventricle intersection_of: UBERON:0001081 ! endocardium of ventricle intersection_of: BFO:0000050 UBERON:0002080 ! part of heart right ventricle relationship: BFO:0000050 UBERON:0002080 ! part of heart right ventricle relationship: RO:0002202 UBERON:0004706 {source="EHDAA2"} ! develops from bulbus cordis relationship: RO:0002371 UBERON:0006567 {source="FMA"} ! attached to right ventricle myocardium property_value: skos:prefLabel "endocardium of right ventricle" xsd:string [Term] id: UBERON:0009713 name: endocardium of left ventricle def: "Any endocardium that is part of the left ventricle of the heart." [http://orcid.org/0000-0002-6601-2165] synonym: "endocardial lining of left ventricle" RELATED [EMAPA:17338] synonym: "left ventricle endocardial tissue" RELATED [VHOG:0001233] synonym: "left ventricle endocardium" EXACT [VHOG:0001233] synonym: "left ventricular endocardium" EXACT [FMA:9559] xref: EHDAA2:0002182 xref: EMAPA:17338 xref: FMA:9559 xref: SCTID:191004004 xref: VHOG:0001233 is_a: UBERON:0001081 ! endocardium of ventricle intersection_of: UBERON:0001081 ! endocardium of ventricle intersection_of: BFO:0000050 UBERON:0002084 ! part of heart left ventricle relationship: BFO:0000050 UBERON:0002084 ! part of heart left ventricle relationship: RO:0002371 UBERON:0006566 {source="FMA"} ! attached to left ventricle myocardium property_value: skos:prefLabel "endocardium of left ventricle" xsd:string [Term] id: UBERON:0009714 name: intermaxillary process def: "The primordial mass of tissue formed by the merging of the medial nasal prominences of the embryo; it contributes to the intermaxillary portion of the upper jaw, the prolabial portion of the upper lip, and the primary palate." [http://www.medilexicon.com/medicaldictionary.php?s=intermaxillary+segment] synonym: "globular process" RELATED DEPRECATED [Wikipedia:Intermaxillary_segment] synonym: "globular processes of his" RELATED DEPRECATED [Wikipedia:Intermaxillary_segment] synonym: "intermaxillary segment" RELATED [Wikipedia:Intermaxillary_segment] xref: EHDAA2:0000868 xref: EHDAA:7856 xref: FMA:295872 xref: Wikipedia:Intermaxillary_segment is_a: BFO:0000002 is_a: UBERON:0009292 {source="EHDAA2-modified"} ! embryonic nasal process relationship: RO:0002202 UBERON:0004067 ! develops from lateral nasal prominence relationship: RO:0002202 UBERON:0004068 {source="EHDAA2"} ! develops from medial nasal prominence property_value: IAO:0000116 "requires verification. Note EHDAA2 has this as coming from both lateral and medial prominences. See also: median cleft lip" xsd:string property_value: skos:prefLabel "intermaxillary process" xsd:string [Term] id: UBERON:0009715 name: stomodeal lumen def: "An anatomical cavity that surrounded_by a stomodeum." [OBOL:automatic] synonym: "lumen of stomatodaeum" EXACT [] synonym: "lumen of stomodeum" EXACT [] synonym: "stomatodeal cavity" EXACT [] is_a: UBERON:0000464 ! anatomical space intersection_of: UBERON:0000464 ! anatomical space intersection_of: RO:0002572 UBERON:0000930 ! luminal space of stomodeum relationship: RO:0002572 UBERON:0000930 ! luminal space of stomodeum property_value: skos:prefLabel "stomodeal lumen" xsd:string [Term] id: UBERON:0009722 name: entire pharyngeal arch endoderm synonym: "pharyngeal arch endoderm" RELATED [EHDAA2:0004621] xref: EHDAA2:0004621 xref: EMAPA:32754 xref: FMA:293087 is_a: UBERON:0005291 ! embryonic tissue is_a: UBERON:0005911 ! endo-epithelium is_a: UBERON:0015833 ! foregut epithelium relationship: BFO:0000050 UBERON:0003929 {source="EHDAA2"} ! part of digestive tract epithelium relationship: BFO:0000050 UBERON:0008814 ! part of pharyngeal arch system property_value: skos:prefLabel "entire pharyngeal arch endoderm" xsd:string [Term] id: UBERON:0009731 name: sublaminar layers S3 or S4 def: "One of sublaminar layers S3 or S4." [GOC:plr, https://github.com/obophenotype/uberon/issues/31] xref: CP:0001040 is_a: UBERON:0009734 ! sublaminar layers S2 or S3 or S4 is_a: UBERON:0009735 ! sublaminar layers S1 or S3 or S4 is_a: UBERON:0009736 ! sublaminar layers S3 or S4 or S5 union_of: UBERON:0008924 ! sublaminar layer S3 union_of: UBERON:0008925 ! sublaminar layer S4 property_value: terms:contributor https://orcid.org/0000-0002-6601-2165 property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 [Term] id: UBERON:0009732 name: sublaminar layers S1 or S2 or S5 def: "One of sublaminar layers S1, S2, or S5." [GOC:plr, https://github.com/obophenotype/uberon/issues/31] xref: CP:0001041 is_a: UBERON:0008921 ! substratum of layer of retina union_of: UBERON:0008922 ! sublaminar layer S1 union_of: UBERON:0008923 ! sublaminar layer S2 union_of: UBERON:0008926 ! sublaminar layer S5 property_value: terms:contributor https://orcid.org/0000-0002-6601-2165 property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 [Term] id: UBERON:0009733 name: sublaminar layers S1 or S2 or S3 def: "One of sublaminar layers S1, S2, or S3." [GOC:plr, https://github.com/obophenotype/uberon/issues/31] xref: CP:0001042 is_a: UBERON:0009737 ! sublaminar layers S1 or S2 or S3 or S4 union_of: UBERON:0008922 ! sublaminar layer S1 union_of: UBERON:0008923 ! sublaminar layer S2 union_of: UBERON:0008924 ! sublaminar layer S3 property_value: terms:contributor https://orcid.org/0000-0002-6601-2165 property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 [Term] id: UBERON:0009734 name: sublaminar layers S2 or S3 or S4 def: "One of sublaminar layers S2, S3, or S4." [GOC:plr, https://github.com/obophenotype/uberon/issues/31] xref: CP:0001043 is_a: UBERON:0009737 ! sublaminar layers S1 or S2 or S3 or S4 union_of: UBERON:0008923 ! sublaminar layer S2 union_of: UBERON:0008924 ! sublaminar layer S3 union_of: UBERON:0008925 ! sublaminar layer S4 property_value: terms:contributor https://orcid.org/0000-0002-6601-2165 property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 [Term] id: UBERON:0009735 name: sublaminar layers S1 or S3 or S4 def: "One of sublaminar layers S1, S3, or S4." [GOC:plr, https://github.com/obophenotype/uberon/issues/31] xref: CP:0001044 is_a: UBERON:0009737 ! sublaminar layers S1 or S2 or S3 or S4 union_of: UBERON:0008922 ! sublaminar layer S1 union_of: UBERON:0008924 ! sublaminar layer S3 union_of: UBERON:0008925 ! sublaminar layer S4 property_value: terms:contributor https://orcid.org/0000-0002-6601-2165 property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 [Term] id: UBERON:0009736 name: sublaminar layers S3 or S4 or S5 def: "One of sublaminar layers S3, S4, or S5." [GOC:plr, https://github.com/obophenotype/uberon/issues/31] xref: CP:0001045 is_a: UBERON:0008921 ! substratum of layer of retina union_of: UBERON:0008924 ! sublaminar layer S3 union_of: UBERON:0008925 ! sublaminar layer S4 union_of: UBERON:0008926 ! sublaminar layer S5 property_value: terms:contributor https://orcid.org/0000-0002-6601-2165 property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 [Term] id: UBERON:0009737 name: sublaminar layers S1 or S2 or S3 or S4 def: "One of sublaminar layers S1, S2, S3, or S4." [GOC:plr, https://github.com/obophenotype/uberon/issues/31] xref: CP:0001046 is_a: UBERON:0008921 ! substratum of layer of retina union_of: UBERON:0008922 ! sublaminar layer S1 union_of: UBERON:0008923 ! sublaminar layer S2 union_of: UBERON:0008924 ! sublaminar layer S3 union_of: UBERON:0008925 ! sublaminar layer S4 property_value: terms:contributor https://orcid.org/0000-0002-6601-2165 property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 [Term] id: UBERON:0009738 name: border of sublaminar layers S1 and S2 def: "The region extending out from the boundary between layers S1 and S2." [GOC:plr, https://github.com/obophenotype/uberon/issues/31, https://orcid.org/0000-0002-6601-2165] xref: CP:0001038 is_a: UBERON:0009740 ! border between sublaminar layers intersection_of: UBERON:0009740 ! border between sublaminar layers intersection_of: RO:0002131 UBERON:0008922 ! overlaps sublaminar layer S1 intersection_of: RO:0002131 UBERON:0008923 ! overlaps sublaminar layer S2 relationship: BFO:0000050 UBERON:0008927 ! part of sublaminar layers S1 or S2 relationship: RO:0002131 UBERON:0008922 ! overlaps sublaminar layer S1 relationship: RO:0002131 UBERON:0008923 ! overlaps sublaminar layer S2 property_value: terms:contributor https://orcid.org/0000-0002-6601-2165 property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 [Term] id: UBERON:0009739 name: border of sublaminar layers S3 and S4 def: "The region extending out from the boundary between sublaminar layers S3 and S4." [GOC:plr, https://github.com/obophenotype/uberon/issues/31, https://orcid.org/0000-0002-6601-2165] xref: CP:0001039 is_a: UBERON:0009740 ! border between sublaminar layers intersection_of: UBERON:0009740 ! border between sublaminar layers intersection_of: RO:0002131 UBERON:0008924 ! overlaps sublaminar layer S3 intersection_of: RO:0002131 UBERON:0008925 ! overlaps sublaminar layer S4 relationship: BFO:0000050 UBERON:0009731 ! part of sublaminar layers S3 or S4 relationship: RO:0002131 UBERON:0008924 ! overlaps sublaminar layer S3 relationship: RO:0002131 UBERON:0008925 ! overlaps sublaminar layer S4 property_value: terms:contributor https://orcid.org/0000-0002-6601-2165 property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 [Term] id: UBERON:0009740 name: border between sublaminar layers def: "A region of the retina corresponding to a portion of two adjacent substratum layers." [https://orcid.org/0000-0002-6601-2165] is_a: UBERON:0022303 ! nervous system cell part layer relationship: BFO:0000050 UBERON:0000966 ! part of retina relationship: RO:0002131 UBERON:0008921 ! overlaps substratum of layer of retina [Term] id: UBERON:0009744 name: lymph node medullary sinus def: "The channels in the lymph node medulla that separate the medullary cords and are crossed by a reticulum of cells and fibers and bounded by littoral cells; lymph flows through the medullary sinus from the cortical sinuses and into the efferent lymphatic vessels." [MP:0011222] comment: Lymph flows into the medullary sinuses from cortical sinuses, and into efferent lymphatic vessels. Medullary sinuses contain histiocytes (immobile macrophages) and reticular cells.[WP] subset: human_reference_atlas subset: pheno_slim synonym: "lymph node medullary sinusoid" RELATED [] synonym: "medullary sinus" BROAD [] xref: EMAPA:37898 {source="MA:th"} xref: FMA:312359 is_a: UBERON:0004111 ! anatomical conduit relationship: BFO:0000050 UBERON:0002007 ! part of medulla of lymph node relationship: channel_for UBERON:0002391 ! lymph property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0009745 name: lymph node medullary cord def: "The dense rope-like structures of lymphatic tissue located between the medullary sinuses in the medulla of a lymph node." [MP:0011224] subset: human_reference_atlas subset: pheno_slim synonym: "medullary cord" BROAD [] xref: EMAPA:37897 {source="MA:th"} is_a: UBERON:0000064 ! organ part relationship: BFO:0000050 UBERON:0002007 ! part of medulla of lymph node relationship: RO:0002220 UBERON:0009744 ! adjacent to lymph node medullary sinus property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0009749 name: limb mesenchyme def: "The primordial embryonic connective tissue of the developing limbs, autopods and digits, consisting of mesenchymal cells supported in interlaminar jelly, that derive mostly from the mesoderm and contribute to limb connective tissue, bone and musculature in conjunction with myotome cells." [MP:0011261] subset: pheno_slim synonym: "limb mesoderm" RELATED [Geisha:syn, NCBITaxon:8782] xref: EMAPA:32705 is_a: UBERON:0003104 ! mesenchyme intersection_of: UBERON:0003104 ! mesenchyme intersection_of: BFO:0000050 UBERON:0002101 ! part of limb relationship: BFO:0000050 UBERON:0002101 ! part of limb [Term] id: UBERON:0009751 name: cardiac mesenchyme def: "The embryonic connective tissue made up of loosely aggregated mesenchymal cells, supported by interlaminar jelly, that gives rise to the developing cardiac structures." [MP:0011264] subset: pheno_slim synonym: "heart mesenchyme" EXACT [EMAPA:36438] xref: EHDAA2:0004162 xref: EMAPA:36438 is_a: UBERON:0003104 ! mesenchyme intersection_of: UBERON:0003104 ! mesenchyme intersection_of: BFO:0000050 UBERON:0000948 ! part of heart relationship: BFO:0000050 UBERON:0000948 ! part of heart property_value: IAO:0000116 "decide whether to merge with cardiac mesoderm. In EHDAA2 this lasts CS12->unbounded, includes mesenchyme of individual components as parts" xsd:string property_value: skos:prefLabel "cardiac mesenchyme" xsd:string [Term] id: UBERON:0009752 name: pancreas mesenchyme def: "The embryonic connective tissue made up of loosely aggregated mesenchymal cells, supported by interlaminar jelly, that gives rise to the developing pancreas." [MP:0011265] subset: efo_slim subset: human_reference_atlas subset: pheno_slim xref: EFO:0002557 xref: EMAPA:26220 is_a: UBERON:0003104 ! mesenchyme intersection_of: UBERON:0003104 ! mesenchyme intersection_of: BFO:0000050 UBERON:0001264 ! part of pancreas relationship: BFO:0000050 UBERON:0001264 ! part of pancreas property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "pancreas mesenchyme" xsd:string [Term] id: UBERON:0009753 name: adrenal gland cortex zone synonym: "adrenal cortical region" EXACT [FMA:69086] synonym: "region of adrenal cortex" RELATED [FMA:69086] xref: EMAPA:35113 xref: FMA:69086 xref: MA:0001887 xref: SCTID:68594002 is_a: UBERON:0000064 ! organ part relationship: BFO:0000050 UBERON:0001235 {source="MA"} ! part of adrenal cortex [Term] id: UBERON:0009758 name: abdominal ganglion def: "A ganglion that is part of a abdominal segment of trunk." [OBOL:automatic] xref: SCTID:280508003 is_a: UBERON:0007134 ! trunk ganglion intersection_of: UBERON:0000045 ! ganglion intersection_of: BFO:0000050 UBERON:0002417 ! part of abdominal segment of trunk relationship: BFO:0000050 UBERON:0002417 ! part of abdominal segment of trunk property_value: skos:prefLabel "abdominal ganglion" xsd:string [Term] id: UBERON:0009767 name: proximal interphalangeal joint def: "An inter-phalangeal joint that connects a proximal phalanx to either a medial or distal phalanx." [http://orcid.org/0000-0002-6601-2165] subset: pheno_slim synonym: "PIJ joint" NARROW [Wikipedia:Interphalangeal_articulations_of_the_hand] synonym: "PIP joint" NARROW [Wikipedia:Interphalangeal_articulations_of_the_hand] xref: FMA:65022 xref: NCIT:C101528 is_a: UBERON:0006658 ! interphalangeal joint intersection_of: UBERON:0006658 ! interphalangeal joint intersection_of: RO:0002176 UBERON:0004302 ! connects proximal phalanx relationship: RO:0002176 UBERON:0004301 ! connects middle phalanx relationship: RO:0002176 UBERON:0004302 ! connects proximal phalanx [Term] id: UBERON:0009768 name: distal interphalangeal joint def: "An inter-phalangeal joint that connects a distal phalanx to either a medial or proximal phalanx." [http://orcid.org/0000-0002-6601-2165] subset: pheno_slim synonym: "DIJ joint" NARROW [Wikipedia:Interphalangeal_articulations_of_the_hand] synonym: "DIP joint" NARROW [Wikipedia:Interphalangeal_articulations_of_the_hand] xref: FMA:65024 xref: NCIT:C101529 is_a: UBERON:0006658 ! interphalangeal joint intersection_of: UBERON:0006658 ! interphalangeal joint intersection_of: RO:0002176 UBERON:0004300 ! connects distal phalanx relationship: RO:0002176 UBERON:0004300 ! connects distal phalanx [Term] id: UBERON:0009773 name: renal tubule def: "A renal tubule is a tube that filters, re-absorbs and secretes substances to rid an organism of waste and to play a role in fluid homeostasis." [DOI:10.1371/journal.pone.0099864, GO:0061333, GOC:dph, GOC:mtg_kidney_jan10] subset: grouping_class subset: pheno_slim synonym: "renal tubule (generic)" EXACT [https://orcid.org/0000-0002-6601-2165] synonym: "tubule of excretory system" EXACT [https://orcid.org/0000-0002-6601-2165, OBOL:automatic] is_a: UBERON:0003914 ! epithelial tube is_a: UBERON:0006555 ! excretory tube relationship: RO:0002162 NCBITaxon:33213 ! in taxon Bilateria [Term] id: UBERON:0009778 name: pleural sac def: "A serous sac that has the pleura and the pleural cavity as parts." [https://github.com/obophenotype/uberon/issues/86] subset: non_informative xref: EHDAA2:0004737 xref: FMA:9690 xref: SCTID:361996004 is_a: UBERON:0005906 ! serous sac is_a: UBERON:0015212 ! lateral structure intersection_of: UBERON:0005906 ! serous sac intersection_of: BFO:0000051 UBERON:0000977 ! has part pleura intersection_of: BFO:0000051 UBERON:0002402 ! has part pleural cavity relationship: BFO:0000050 UBERON:0001558 {source="FMA"} ! part of lower respiratory tract relationship: BFO:0000051 UBERON:0000977 ! has part pleura relationship: BFO:0000051 UBERON:0002402 ! has part pleural cavity relationship: BSPO:0000126 UBERON:0001004 {source="FMA-abduced-lr"} ! respiratory system property_value: skos:prefLabel "pleural sac" xsd:string [Term] id: UBERON:0009841 name: upper rhombic lip def: "Anterior-most region of dorsal hindbrain within rhombomere 1, adjacent the midbrain-hindbrain boundary." [ZFIN:curator] subset: pheno_slim synonym: "cerebellar anlage" EXACT [ZFA:0001442] synonym: "presumptive cerebellum" EXACT [ZFA:0001442] synonym: "rhombomere 01 cerebellum primordium" RELATED [EHDAA2:0000229] synonym: "rostral rhombic lip" EXACT [DHB:URL] synonym: "upper (rostral) rhombic lip" EXACT [] xref: DHBA:10665 xref: EHDAA2:0000229 xref: TAO:0001442 xref: ZFA:0001442 is_a: UBERON:0002616 ! regional part of brain relationship: BFO:0000050 UBERON:0005499 {source="ZFA"} ! part of rhombomere 1 relationship: BFO:0000050 UBERON:0006215 {source="ZFA"} ! part of rhombic lip relationship: RO:0002220 UBERON:0003052 {source="ZFA-def"} ! adjacent to midbrain-hindbrain boundary property_value: skos:prefLabel "upper rhombic lip" xsd:string [Term] id: UBERON:0009842 name: glandular acinus def: "The many-lobed berry cluster of cells that is the terminous of a gland where the secretion is produced is acinar in form." [Wikipedia:Acinus] synonym: "acini" RELATED OMO:0003004 [Wikipedia:Acinus] synonym: "acinus" BROAD [FMA:55588] xref: FMA:55588 xref: Wikipedia:Acinus is_a: UBERON:0034922 ! cell cluster intersection_of: UBERON:0034922 ! cell cluster intersection_of: BFO:0000050 UBERON:0002530 ! part of gland intersection_of: BFO:0000051 CL:0000151 ! has part secretory cell intersection_of: RO:0000086 PATO:0002422 ! has quality acinar relationship: BFO:0000050 UBERON:0002530 ! part of gland relationship: BFO:0000051 CL:0000151 ! has part secretory cell relationship: RO:0000086 PATO:0002422 ! has quality acinar property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/9/99/Gray1105.png" xsd:anyURI property_value: skos:prefLabel "glandular acinus" xsd:string [Term] id: UBERON:0009843 name: prostate epithelial cord def: "A solid cord of prostate epithelium." [GO:0060527, OBOL:automatic, PMID:18977204] comment: Complexity is conferred on the prostate during a postnatal development phase known as branching morphogenesis. Solid cords of prostate epithelium formed in utero elongate postnatally and their tips are bifurcated into primary, secondary, and tertiary branches in a pattern that is unique for each prostate lobe. Branching morphogenesis proceeds differentially for each of the three mouse prostate lobes (ventral, dorsolateral, and anterior) and is completed by about postnatal day 20 in mice, providing each lobe with unique glandular architecture [5]. It is important to note that the developing human prostate undergoes a similar series of morphogenetic events especially during prostatic bud formation, but gives rise to a mature glandular prostate that is unique from the rodent and features peripheral, central, and transitional zones[PMID:18977204] synonym: "cord of prostate epithelium" EXACT [PMID:18977204] synonym: "epithelial cord of prostate" EXACT [] is_a: UBERON:0005154 ! epithelial cord intersection_of: UBERON:0005154 ! epithelial cord intersection_of: RO:0002387 UBERON:0002367 ! has potential to develop into prostate gland relationship: RO:0002387 UBERON:0002367 ! has potential to develop into prostate gland [Term] id: UBERON:0009844 name: urogenital sinus lumen def: "An anatomical space that surrounded_by a primitive urogenital sinus." [OBOL:automatic] xref: EHDAA2:0002142 is_a: BFO:0000002 is_a: UBERON:0000464 ! anatomical space intersection_of: UBERON:0000464 ! anatomical space intersection_of: RO:0002572 UBERON:0000164 ! luminal space of primitive urogenital sinus relationship: RO:0002202 UBERON:0009669 {source="EHDAA2"} ! develops from embryonic cloacal lumen relationship: RO:0002219 UBERON:0004902 ! surrounded by urogenital sinus epithelium relationship: RO:0002572 UBERON:0000164 ! luminal space of primitive urogenital sinus [Term] id: UBERON:0009845 name: urogenital sinus mesenchyme def: "Mesenchyme that surrounds primitive urogenital sinus." [OBOL:automatic] synonym: "UGM" EXACT OMO:0003000 [PMID:18977204] xref: EMAPA:31500 is_a: UBERON:0003104 ! mesenchyme intersection_of: UBERON:0003104 {source="PMID:18977204"} ! mesenchyme intersection_of: RO:0002221 UBERON:0000164 {source="PMID:18977204"} ! surrounds primitive urogenital sinus relationship: RO:0002221 UBERON:0000164 ! surrounds primitive urogenital sinus [Term] id: UBERON:0009846 name: embryonic cloacal epithelium def: "An epithelium that is part of a embryonic cloaca." [OBOL:automatic] synonym: "cloacal epithelium" BROAD [EHDAA2:0004585] xref: EHDAA2:0004585 is_a: UBERON:0005291 ! embryonic tissue is_a: UBERON:0009521 ! anal membrane endodermal component is_a: UBERON:0012481 ! cloacal epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: BFO:0000050 UBERON:0000163 ! part of embryonic cloaca relationship: BFO:0000050 UBERON:0000163 ! part of embryonic cloaca relationship: BFO:0000050 UBERON:0003929 {source="EHDAA2"} ! part of digestive tract epithelium relationship: RO:0002202 UBERON:0003353 {source="EHDAA2"} ! develops from epithelium of hindgut property_value: skos:prefLabel "embryonic cloacal epithelium" xsd:string [Term] id: UBERON:0009847 name: prostate field def: "A specific region of the urogenital sinus epithelium into the area in which the prostate gland will develop." [GO:0060515, GOC:dph, PMID:18977204] synonym: "prostate primordium" RELATED [] is_a: BFO:0000002 is_a: UBERON:0005291 ! embryonic tissue is_a: UBERON:0006598 ! presumptive structure is_a: UBERON:0007688 ! anlage intersection_of: UBERON:0007688 ! anlage intersection_of: RO:0002387 UBERON:0002367 ! has potential to develop into prostate gland relationship: BFO:0000050 UBERON:0004902 {source="PMID:18977204"} ! part of urogenital sinus epithelium relationship: RO:0002256 UBERON:0009845 {source="PMID:18977204"} ! developmentally induced by urogenital sinus mesenchyme relationship: RO:0002387 UBERON:0002367 ! has potential to develop into prostate gland [Term] id: UBERON:0009848 name: zona limitans intrathalamica def: "A narrow stripe of cells that lies between the prospective dorsal and ventral thalami. This boundary contains signals that pattern the prethalamic and thalamic territories of the future mid-diencephalon." [GO:0022006, GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:11425897, PMID:16452095, Wikipedia:Zona_limitans_intrathalamica] synonym: "MDO" RELATED OMO:0003000 [Wikipedia:Thalamus] synonym: "mid-diencephalic organizer" RELATED [Wikipedia:Thalamus] synonym: "ZLI" EXACT OMO:0003000 [GO:0022006] synonym: "ZLI organizer" RELATED [Wikipedia:Thalamus] xref: EMAPA:36604 xref: TAO:0001344 xref: Wikipedia:Zona_limitans_intrathalamica xref: XAO:0004305 xref: ZFA:0001344 is_a: UBERON:0007651 ! anatomical junction intersection_of: UBERON:0007651 ! anatomical junction intersection_of: RO:0002220 UBERON:0001900 ! adjacent to ventral thalamus intersection_of: RO:0002220 UBERON:0004703 ! adjacent to dorsal thalamus relationship: BFO:0000050 UBERON:0001897 {source="ZFA"} ! part of dorsal plus ventral thalamus relationship: RO:0002220 UBERON:0001900 ! adjacent to ventral thalamus relationship: RO:0002220 UBERON:0004703 ! adjacent to dorsal thalamus property_value: IAO:0000116 "Modeling this as a line may not be correct - see http://code.google.com/p/caro2/issues/detail?id=17" xsd:string property_value: skos:prefLabel "zona limitans intrathalamica" xsd:string [Term] id: UBERON:0009851 name: border of sublaminar layers S4 and S5 def: "The intersection of sublaminar layers S4 and S5." [GOC:tfm, https://github.com/obophenotype/uberon/issues/31] is_a: UBERON:0009740 ! border between sublaminar layers intersection_of: UBERON:0009740 ! border between sublaminar layers intersection_of: RO:0002131 UBERON:0008925 ! overlaps sublaminar layer S4 intersection_of: RO:0002131 UBERON:0008926 ! overlaps sublaminar layer S5 relationship: BFO:0000050 UBERON:0008929 ! part of sublaminar layers S4 or S5 relationship: RO:0002131 UBERON:0008925 ! overlaps sublaminar layer S4 relationship: RO:0002131 UBERON:0008926 ! overlaps sublaminar layer S5 property_value: terms:contributor https://orcid.org/0000-0002-6601-2165 property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 [Term] id: UBERON:0009852 name: border of sublaminar layers S2 and S3 def: "The intersection of sublaminar layers S2 and S3." [GOC:tfm, https://github.com/obophenotype/uberon/issues/31] is_a: UBERON:0009740 ! border between sublaminar layers intersection_of: UBERON:0009740 ! border between sublaminar layers intersection_of: RO:0002131 UBERON:0008923 ! overlaps sublaminar layer S2 intersection_of: RO:0002131 UBERON:0008924 ! overlaps sublaminar layer S3 relationship: BFO:0000050 UBERON:0008928 ! part of sublaminar layers S2 or S3 relationship: RO:0002131 UBERON:0008923 ! overlaps sublaminar layer S2 relationship: RO:0002131 UBERON:0008924 ! overlaps sublaminar layer S3 property_value: terms:contributor https://orcid.org/0000-0002-6601-2165 property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 [Term] id: UBERON:0009854 name: digestive tract diverticulum def: "Branch or outpocketing of the digestive tract." [https://orcid.org/0000-0002-6601-2165] synonym: "diverticulum of gut" RELATED [FBbt:00100316] synonym: "intestinal pouch" RELATED [] xref: FBbt:00100316 {sssom:mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"} is_a: UBERON:0004921 ! subdivision of digestive tract is_a: UBERON:0009856 ! sac intersection_of: UBERON:0009856 ! sac intersection_of: BFO:0000050 UBERON:0001555 ! part of digestive tract property_value: skos:prefLabel "digestive tract diverticulum" xsd:string [Term] id: UBERON:0009856 name: sac synonym: "diverticulum" RELATED [] synonym: "pouch" EXACT [] xref: galen:Diverticulum is_a: UBERON:0000061 ! anatomical structure intersection_of: UBERON:0000061 ! anatomical structure intersection_of: RO:0000086 PATO:0001987 ! has quality saccular relationship: RO:0000086 PATO:0001987 ! has quality saccular property_value: skos:prefLabel "sac" xsd:string [Term] id: UBERON:0009859 name: endosteum def: "A thin layer of connective tissue that lines the surface of the bony tissue that forms the medullary cavity of long bones." [Wikipedia:Endosteum] subset: pheno_slim xref: FMA:32692 xref: NCIT:C13183 xref: SCTID:57487002 xref: UMLS:C0222658 {source="ncithesaurus:Endosteum"} xref: Wikipedia:Endosteum is_a: UBERON:0000158 ! membranous layer relationship: BFO:0000050 UBERON:0002495 ! part of long bone relationship: RO:0002220 UBERON:0002484 ! adjacent to bone marrow cavity relationship: RO:0002473 UBERON:0011825 ! composed primarily of loose connective tissue property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/9/94/Illu_long_bone.jpg" xsd:anyURI [Term] id: UBERON:0009870 name: zone of stomach def: "A division of the stomach. The stomach can be divided based on mucosal histology (glandular epithelium and gastric glands) and the relative position and type of gastric gland." [ISBN:0073040584, Wikipedia:Stomach#Sections] synonym: "gastric zone" EXACT [FMA:14558] synonym: "region of stomach" EXACT [] synonym: "section of stomach" EXACT [] xref: EMAPA:35821 xref: FMA:14558 xref: MA:0002561 xref: SCTID:245415005 xref: Wikipedia:Stomach#Sections is_a: UBERON:0004921 ! subdivision of digestive tract is_a: UBERON:0034944 ! zone of organ intersection_of: UBERON:0034944 ! zone of organ intersection_of: BFO:0000050 UBERON:0000945 ! part of stomach relationship: BFO:0000050 UBERON:0000945 ! part of stomach property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/2/29/Regions_of_stomach.svg" xsd:anyURI property_value: IAO:0000116 "We follow Kardong in defining stomach regions by gland, but we also include 'body of stomach'. In future we may want to have different partitions of the stomach" xsd:string property_value: skos:prefLabel "zone of stomach" xsd:string [Term] id: UBERON:0009871 name: nephrogenic zone def: "Outer portion of the renal cortex. Site of formation of medullary and cortical elements." [http://orcid.org/0000-0002-6601-2165] subset: pheno_slim synonym: "cortical nephrogenic niche" EXACT [PMID:29449449] synonym: "cortical nephrogenic zone" EXACT [PMID:29449449] synonym: "nephrogenic tissue" RELATED [] xref: EMAPA:27721 xref: http://www.gudmap.org/Images/Organ_Summaries/Metanephros/NZ.png xref: MA:0002996 is_a: UBERON:0005423 ! developing anatomical structure relationship: BFO:0000050 UBERON:0001225 ! part of cortex of kidney [Term] id: UBERON:0009877 name: metapodium region def: "Intermediate segment of the autopod, between the mesopodial region and and acropodial region. Examples: metacarpal region, metatarsal region." [https://orcid.org/0000-0002-6601-2165, MA:th] synonym: "cannon region" NARROW [http://orcid.org/0000-0002-6601-2165, NCBITaxon:9788] synonym: "equine cannon region" NARROW [http://orcid.org/0000-0002-6601-2165, NCBITaxon:9788] synonym: "metacarpal or metatarsal part of limb" EXACT [] synonym: "metacarpus/metatarsus" RELATED [] synonym: "metacarpus/metatarsus region" EXACT [] synonym: "metapodial segment" EXACT [] synonym: "metapodium" RELATED [] xref: SCTID:370640001 is_a: UBERON:0002529 ! limb segment intersection_of: UBERON:0002529 ! limb segment intersection_of: RO:0002551 UBERON:0010546 ! has skeleton metapodial skeleton relationship: BFO:0000050 UBERON:0012140 {source="PHENOSCAPE:ni"} ! part of digitopodium region relationship: proximally_connected_to UBERON:0006716 ! mesopodium region relationship: RO:0002551 UBERON:0010546 ! has skeleton metapodial skeleton property_value: IAO:0000116 "considering adding 'acropodial region'" xsd:string [Term] id: UBERON:0009878 name: mesopodial skeleton def: "The collection of all skeletal elements in a mesopodium. Examples: the tarsal skeleton, the carpal skeleton." [https://orcid.org/0000-0002-6601-2165] synonym: "basipodium" RELATED [VSAO:0005022, VSAO:NI] synonym: "basipodium skeleton" EXACT [VSAO:0005022, VSAO:NI] synonym: "carpal/tarsal skeleton" EXACT [] synonym: "mesopodial skeleton" EXACT [VSAO:0005022] synonym: "mesopodium" RELATED [VSAO:0005022, VSAO:NI] synonym: "mesopodium skeleton" EXACT [https://orcid.org/0000-0002-6601-2165] synonym: "skeletal parts of mesopodium" EXACT [https://orcid.org/0000-0002-6601-2165] xref: VSAO:0005022 is_a: UBERON:0010712 ! limb skeleton subdivision intersection_of: UBERON:0010912 ! subdivision of skeleton intersection_of: RO:0002576 UBERON:0006716 ! skeleton of mesopodium region relationship: BFO:0000050 UBERON:0006717 ! part of autopodial skeleton relationship: distally_connected_to UBERON:0010546 ! metapodial skeleton relationship: proximally_connected_to UBERON:0011584 ! zeugopodial skeleton relationship: RO:0002576 UBERON:0006716 ! skeleton of mesopodium region [Term] id: UBERON:0009879 name: tarsal skeleton def: "Subdivision of skeleton that consists of endochondral elements distal to the zeugopodial skeletal elements which constitute the proximal region of the posterior autopod skeleton[PHENOSCAPE:ad]." [https://github.com/obophenotype/uberon/issues/94, PHENOSCAPE:ad, VSAO:0005024] subset: pheno_slim synonym: "basipodium" RELATED [VSAO:0005024] synonym: "hind mesopodial skeleton" EXACT [] synonym: "hind mesopodium" EXACT [] synonym: "hind mesopodium skeleton" EXACT [] synonym: "mesopodium" RELATED [VSAO:0005024] synonym: "set of tarsal bones" EXACT [FMA:71339] synonym: "skeletal parts of hind mesopodium" EXACT [] synonym: "tarsal bones" RELATED [] synonym: "tarsal bones set" EXACT [FMA:71339] synonym: "tarsalia" EXACT [XAO:0003211] synonym: "tarsus" RELATED [XAO:0003211] xref: AAO:0000220 xref: EMAPA:19133 xref: FMA:71339 xref: GAID:1223 xref: MA:0000050 xref: SCTID:264228001 xref: SCTID:361796005 xref: VHOG:0001160 xref: VSAO:0005024 xref: Wikipedia:Tarsus_(skeleton) xref: XAO:0003211 is_a: UBERON:0009878 ! mesopodial skeleton intersection_of: UBERON:0010912 ! subdivision of skeleton intersection_of: RO:0002576 UBERON:0004454 ! skeleton of tarsal region relationship: BFO:0000050 UBERON:0001445 ! part of skeleton of pes relationship: distally_connected_to UBERON:0010545 ! metatarsus skeleton relationship: proximally_connected_to UBERON:0010720 ! hindlimb zeugopod skeleton relationship: RO:0002576 UBERON:0004454 ! skeleton of tarsal region property_value: terms:contributor https://orcid.org/0000-0001-7972-3866 property_value: terms:contributor https://orcid.org/0000-0001-9114-8737 property_value: terms:contributor https://orcid.org/0000-0002-6601-2165 [Term] id: UBERON:0009880 name: carpal skeleton def: "Subdivision of skeleton that consists of the endochondral elements distal to the anterior limb/fin zeugopodial skeletal elements which constitute the proximal region of the anterior autopod skeleton[PHENOSCAPE:ad]." [https://github.com/obophenotype/uberon/issues/93, PHENOSCAPE:ad] synonym: "carpal bones" EXACT [EMAPA:25056, FMA:71335] synonym: "carpal bones set" EXACT [FMA:71335] synonym: "carpus" RELATED [MA:0000040, XAO:0003207] synonym: "fore mesopodial skeleton" EXACT [] synonym: "fore mesopodium" RELATED [AAO:0000201] synonym: "fore mesopodium skeleton" EXACT [] synonym: "ossa carpi" EXACT [] synonym: "ossa carpi" RELATED OMO:0003011 [Wikipedia:Carpus] synonym: "set of carpal bones" RELATED [FMA:71335] synonym: "skeletal parts of fore mesopodium" EXACT [] synonym: "skeleton of carpus" EXACT [] xref: AAO:0000201 xref: FMA:71335 xref: http://palaeos.com/vertebrates/glossary/images/382x366xUnciform1.jpg.pagespeed.ic.NirdxtwNVu.jpg xref: MA:0000040 xref: VHOG:0001161 xref: VSAO:0005023 xref: Wikipedia:Carpus xref: XAO:0003207 is_a: UBERON:0009878 ! mesopodial skeleton intersection_of: UBERON:0010912 ! subdivision of skeleton intersection_of: RO:0002576 UBERON:0004452 ! skeleton of carpal region relationship: BFO:0000050 UBERON:0001442 ! part of skeleton of manus relationship: distally_connected_to UBERON:0010544 ! metacarpus skeleton relationship: proximally_connected_to UBERON:0010703 ! forelimb zeugopod skeleton relationship: RO:0002576 UBERON:0004452 ! skeleton of carpal region property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/5/58/Carpus.svg" xsd:anyURI property_value: terms:contributor https://orcid.org/0000-0001-7972-3866 property_value: terms:contributor https://orcid.org/0000-0002-6601-2165 [Term] id: UBERON:0009881 name: anterior lateral plate mesoderm subset: efo_slim synonym: "ALPM" EXACT [ZFA:0005041] xref: EFO:0003704 xref: TAO:0005041 xref: ZFA:0005041 is_a: UBERON:0005291 ! embryonic tissue relationship: BFO:0000050 UBERON:0003081 {source="ZFA"} ! part of lateral plate mesoderm property_value: skos:prefLabel "anterior lateral plate mesoderm" xsd:string [Term] id: UBERON:0009882 name: anal column def: "One of a number of vertical folds, produced by an infolding of the mucous membrane and some of the muscular tissue in the upper half of the lumen of the anal canal[WP]." [Wikipedia:Anal_columns] synonym: "column of Morgagni" EXACT [FMA:15713] synonym: "columnae anales" RELATED OMO:0003011 [Wikipedia:Anal_columns] xref: FMA:15713 xref: NCIT:C32067 xref: SCTID:245444007 xref: UMLS:C0227428 {source="ncithesaurus:Anal_Column"} xref: Wikipedia:Anal_columns is_a: UBERON:0034944 ! zone of organ relationship: BFO:0000050 UBERON:0000159 ! part of anal canal relationship: RO:0000086 PATO:0001910 ! has quality folded property_value: foaf:depiction "https://upload.wikimedia.org/wikipedia/commons/0/01/Gray1078.png" xsd:anyURI [Term] id: UBERON:0009883 name: medullary ray def: "A renal, cortical lobule, consisting of the ascending or descending limbs of the loop of Henle or of the collecting tubules; medullary rays are regions where parallel arrays of straight tubules travel perpendicular to the capsule and extend from the cortex to the medulla." [MP:0011347, Wikipedia:Bone_marrow_of_ovaryry_ray_(anatomy)] subset: human_reference_atlas subset: pheno_slim synonym: "Ferrein's pyramid" EXACT [MP:0011347] synonym: "kidney medullary ray" EXACT [MP:0011347] synonym: "renal medullary ray" EXACT [MP:0011347] xref: BTO:0001155 xref: EMAPA:37906 {source="MA:th"} xref: FMA:74299 xref: Wikipedia:Bone_marrow_of_ovaryry_ray_(anatomy) is_a: UBERON:0000064 {source="FMA"} ! organ part relationship: BFO:0000050 UBERON:0001225 {source="MP"} ! part of cortex of kidney relationship: RO:0002131 UBERON:0001231 ! overlaps nephron tubule relationship: RO:0002433 UBERON:0001225 ! contributes to morphology of cortex of kidney property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0009885 name: interlobar artery def: "An artery that supplies a renal lobe." [http://orcid.org/0000-0002-6601-2165, Wikipedia:Interlobar_arteries] subset: human_reference_atlas subset: pheno_slim synonym: "arteriae interlobares renis" EXACT OMO:0003004 [FMA:TA] synonym: "arteriae interlobares renis" RELATED OMO:0003011 [Wikipedia:Interlobar_arteries] synonym: "interlobar arteries of kidney" RELATED [FMA:71637] synonym: "interlobar artery of kidney" EXACT [FMA:71637] synonym: "kidney interlobar artery" EXACT [] synonym: "renal interlobar artery" EXACT [MP:0011355] synonym: "set of interlobar arteries of kidney" RELATED [FMA:71637] xref: EMAPA:37091 {source="MA:th"} xref: FMA:71637 xref: SCTID:62802007 xref: Wikipedia:Interlobar_arteries is_a: UBERON:0001637 ! artery intersection_of: UBERON:0001637 ! artery intersection_of: RO:0020101 UBERON:0009913 ! vessel supplies blood to renal lobe relationship: RO:0020101 UBERON:0009913 ! vessel supplies blood to renal lobe property_value: foaf:depiction "https://upload.wikimedia.org/wikipedia/commons/7/7e/Kidney_PioM.png" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0009887 name: interlobar vein def: "The interlobar veins are veins of the renal circulation which drain the renal lobes." [Wikipedia:Interlobar_veins] subset: human_reference_atlas synonym: "interlobar vein of kidney" EXACT [FMA:71631] synonym: "interlobar veins of kidney" RELATED [FMA:71631] synonym: "set of interlobar veins of kidney" RELATED [FMA:71631] synonym: "venae interlobares renis" EXACT OMO:0003004 [FMA:TA] synonym: "venae interlobares renis" RELATED OMO:0003011 [Wikipedia:Interlobar_veins] xref: FMA:71631 xref: Wikipedia:Interlobar_veins is_a: UBERON:0001638 ! vein intersection_of: UBERON:0001638 ! vein intersection_of: RO:0020102 UBERON:0009913 ! vessel drains blood from renal lobe relationship: RO:0002170 UBERON:0001140 ! connected to renal vein relationship: RO:0020102 UBERON:0009913 ! vessel drains blood from renal lobe property_value: foaf:depiction "https://upload.wikimedia.org/wikipedia/commons/7/7e/Kidney_PioM.png" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0009889 name: secondary heart field def: "A specific region of the lateral mesoderm that will form the majority of the mesodermal component of the right ventricle, arterial pole (outflow tract) and venous pole (inflow tract)." [GO:0003139, GOC:mtg_heart, GOC:rl] synonym: "anterior heart field" EXACT [PMID:17276708] synonym: "anterior/second heart field" EXACT [Geisha:syn, NCBITaxon:8782] synonym: "second heart field" EXACT [XAO:0004186] synonym: "SHF" RELATED [XAO:0004186] xref: XAO:0004186 is_a: UBERON:0002050 ! embryonic structure is_a: UBERON:0005291 ! embryonic tissue is_a: UBERON:0007688 ! anlage relationship: BFO:0000050 UBERON:0003081 {source="GO:0003129"} ! part of lateral plate mesoderm relationship: BSPO:0000096 UBERON:0004140 {source="PMID:17276708"} ! primary heart field relationship: BSPO:0000098 UBERON:0004140 {source="PMID:17276708"} ! primary heart field relationship: RO:0002162 NCBITaxon:7742 ! in taxon Vertebrata property_value: skos:prefLabel "secondary heart field" xsd:string [Term] id: UBERON:0009891 name: facial mesenchyme def: "Mesenchyme that is part of a developing face." [OBOL:automatic] synonym: "face mesenchyme" EXACT [] synonym: "mesenchyme of face" EXACT [] xref: EMAPA:35337 xref: FMA:302884 is_a: UBERON:0005253 ! head mesenchyme intersection_of: UBERON:0003104 ! mesenchyme intersection_of: BFO:0000050 UBERON:0001456 ! part of face relationship: BFO:0000050 UBERON:0001456 ! part of face property_value: skos:prefLabel "facial mesenchyme" xsd:string [Term] id: UBERON:0009906 name: root of optic nerve def: "A nerve root that extends_fibers_into a nerve connecting eye with brain." [OBOL:automatic] synonym: "optic nerve root" EXACT [BIRNLEX:1328] synonym: "optic tract root" EXACT [FMA:84573] synonym: "root of optic tract" EXACT [FMA:84573] xref: BIRNLEX:1328 xref: FMA:84573 is_a: UBERON:0006843 {source="FMA"} ! root of cranial nerve intersection_of: UBERON:0002211 ! nerve root intersection_of: extends_fibers_into UBERON:0000941 ! cranial nerve II relationship: extends_fibers_into UBERON:0000941 ! cranial nerve II property_value: IAO:0000116 "TODO - check. See comments for optic tract. FMA also has medial root." xsd:string property_value: skos:prefLabel "root of optic nerve" xsd:string [Term] id: UBERON:0009911 name: lobule subset: upper_level synonym: "lobulus" EXACT OMO:0003011 [FMA:45737, FMA:TA] xref: FMA:45737 xref: NCIT:C12990 xref: UMLS:C0921005 {source="ncithesaurus:Lobule"} is_a: UBERON:0000063 {source="cjm"} ! organ subunit property_value: IAO:0000116 "todo - provide definition. Clearly distinguish between lobules, lobes and acinar parts of glands (see for example lobule of mammary gland)" xsd:string property_value: skos:prefLabel "lobule" xsd:string [Term] id: UBERON:0009912 name: anatomical lobe def: "A portion of an organ, such as the liver, lung, breast, or brain." [ncithesaurus:Lobe] subset: upper_level synonym: "lobus" EXACT OMO:0003011 [FMA:45728, FMA:TA] xref: FMA:45728 xref: NCIT:C13393 xref: UMLS:C0796494 is_a: UBERON:0000063 {source="cjm"} ! organ subunit property_value: skos:prefLabel "anatomical lobe" xsd:string [Term] id: UBERON:0009913 name: renal lobe def: "The portion of a kidney consisting of a renal medullary pyramid and the renal cortex above it[MP]. It is composed of many renal lobules[WP]." [MP:0011381, Wikipedia:Renal_lobe] subset: pheno_slim synonym: "kidney lobe" EXACT [MP:0011381] synonym: "lobi renales" RELATED OMO:0003011 [Wikipedia:Renal_lobe] synonym: "lobi renalis" EXACT OMO:0003004 [Wikipedia:Renal_lobe] synonym: "lobus renalis" EXACT [http://www.mondofacto.com/facts/dictionary?lobus+renalis] xref: FMA:17881 xref: NCIT:C32894 xref: UMLS:C0736382 {source="ncithesaurus:Kidney_Lower_Lobe"} xref: Wikipedia:Renal_lobe is_a: UBERON:0009912 ! anatomical lobe intersection_of: UBERON:0009912 ! anatomical lobe intersection_of: BFO:0000050 UBERON:0002113 ! part of kidney relationship: BFO:0000050 UBERON:0002113 ! part of kidney relationship: RO:0002433 UBERON:0002113 ! contributes to morphology of kidney property_value: foaf:depiction "https://upload.wikimedia.org/wikipedia/commons/7/7e/Kidney_PioM.png" xsd:anyURI property_value: IAO:0000116 "todo - add has_part relationships." xsd:string [Term] id: UBERON:0009914 name: renal lobule def: "The portion of a renal lobe consisting of nephrons grouped around a single medullary ray and draining into a single collecting duct; human kidneys have multilobular, multipapillary architecture while mice and rats have unilobular, unipapillary kidneys." [MP:0011382, Wikipedia:Cortical_lobule] comment: Alternate definition: One of the subdivisions of the kidney, consisting of a medullary ray and that portion of the convoluted port (renal corpuscles and convoluted tubules) associated with its collecting duct. -http://www.mondofacto.com/facts/dictionary?lobulus+corticalis+renalis subset: pheno_slim synonym: "cortical lobule" RELATED [MP:0011382, Wikipedia:Cortical_lobule] synonym: "cortical lobule of kidney" RELATED [http://www.mondofacto.com/facts/dictionary?lobus+renalis] synonym: "kidney lobule" EXACT [MP:0011382] synonym: "lobuli corticales renis" RELATED OMO:0003011 [Wikipedia:Cortical_lobule] synonym: "lobulus corticalis renalis" RELATED [http://www.mondofacto.com/facts/dictionary?lobus+renalis] synonym: "lobulus renalis" EXACT [] synonym: "renal cortical lobule" RELATED [http://www.mondofacto.com/facts/dictionary?lobus+renalis] synonym: "renculus" RELATED [http://www.mondofacto.com/facts/dictionary?lobus+renalis] synonym: "reniculus" RELATED [http://www.mondofacto.com/facts/dictionary?lobus+renalis] synonym: "renunculus" RELATED [http://www.mondofacto.com/facts/dictionary?lobus+renalis] xref: FMA:17670 xref: SCTID:361330004 xref: Wikipedia:Cortical_lobule is_a: BFO:0000002 is_a: UBERON:0009911 ! lobule intersection_of: UBERON:0009911 ! lobule intersection_of: BFO:0000050 UBERON:0002113 ! part of kidney relationship: BFO:0000050 UBERON:0009913 {source="FMA"} ! part of renal lobe relationship: BFO:0000051 UBERON:0001285 ! has part nephron relationship: BFO:0000051 UBERON:0009883 ! has part medullary ray relationship: RO:0002433 UBERON:0002113 ! contributes to morphology of kidney [Term] id: UBERON:0009916 name: wall of ureter def: "An anatomical wall that is part of a ureter." [OBOL:automatic] synonym: "ureteral wall" EXACT [FMA:15888] xref: FMA:15888 xref: SCTID:279397004 is_a: BFO:0000002 is_a: UBERON:0000060 ! anatomical wall intersection_of: UBERON:0000060 ! anatomical wall intersection_of: BFO:0000050 UBERON:0000056 ! part of ureter relationship: BFO:0000050 UBERON:0000056 ! part of ureter relationship: BFO:0000051 UBERON:0005742 ! has part adventitia relationship: BFO:0000051 UBERON:0006660 ! has part muscular coat [Term] id: UBERON:0009917 name: kidney corticomedullary boundary def: "The region demarcating the renal medulla from the surrounding cortex; end-stage renal failure may be associated with loss of the normal corticomedullary boundary." [MP:0011376] subset: pheno_slim xref: EMAPA:37886 {source="MA:th"} is_a: UBERON:0007651 ! anatomical junction intersection_of: UBERON:0007651 ! anatomical junction intersection_of: RO:0002220 UBERON:0000362 ! adjacent to renal medulla intersection_of: RO:0002220 UBERON:0001225 ! adjacent to cortex of kidney relationship: BFO:0000050 UBERON:0002113 {source="MP"} ! part of kidney relationship: RO:0002220 UBERON:0000362 ! adjacent to renal medulla relationship: RO:0002220 UBERON:0001225 ! adjacent to cortex of kidney relationship: RO:0002433 UBERON:0002113 ! contributes to morphology of kidney [Term] id: UBERON:0009918 name: retrotrapezoid nucleus def: "The loose collection of neurons that reside in the rostral medulla close to the medullary surface, ventral and immediately caudal of nVII, that are crucial for CO2 sensing in the brain." [MP:0011406] subset: pheno_slim xref: DHBA:12531 xref: DMBA:17327 xref: MA:0003022 is_a: UBERON:0007635 ! nucleus of medulla oblongata property_value: skos:prefLabel "retrotrapezoid nucleus" xsd:string [Term] id: UBERON:0009919 name: ureter smooth muscle def: "The smooth muscle tissue surrounding the epithelium of the ureter." [MP:0011426] subset: human_reference_atlas subset: pheno_slim synonym: "ureteral smooth muscle" EXACT [MP:0011426] synonym: "ureteral smooth muscle layer" EXACT [EMAPA:28844] xref: EMAPA:28811 is_a: UBERON:0001135 ! smooth muscle tissue intersection_of: UBERON:0001135 ! smooth muscle tissue intersection_of: BFO:0000050 UBERON:0000056 ! part of ureter relationship: BFO:0000050 UBERON:0006855 ! part of muscular coat of ureter relationship: RO:0002433 UBERON:0000056 ! contributes to morphology of ureter property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0009920 name: optic neural crest xref: EHDAA2:0001315 xref: EHDAA:1122 is_a: UBERON:0005253 ! head mesenchyme is_a: UBERON:0007530 {source="EHDAA2"} ! migrating mesenchyme population relationship: BFO:0000050 UBERON:0007213 {source="EHDAA2"} ! part of mesenchyme derived from head neural crest property_value: skos:prefLabel "optic neural crest" xsd:string [Term] id: UBERON:0009950 name: olfactory bulb plexiform layer synonym: "plexiform layer" BROAD [NLXANAT:20090405] xref: NLXANAT:20090405 is_a: UBERON:0004001 {source="NIFSTD"} ! olfactory bulb layer property_value: IAO:0000116 "check if the NIF class is actually a grouping class" xsd:string property_value: skos:prefLabel "olfactory bulb plexiform layer" xsd:string [Term] id: UBERON:0009951 name: main olfactory bulb def: "The main olfactory bulb has a multi-layered cellular architecture. In order from surface to the center the layers are: Glomerular layer, External plexiform layer, Mitral cell layer, Internal plexiform layer, Granule cell layer[WP]." [Wikipedia:Olfactory_bulb#Main_olfactory_bulb] xref: BAMS:MOB xref: MBA:507 xref: MESH:D009830 {sssom:mapping_justification="https://w3id.org/semapv/vocab/LexicalMatching"} xref: Wikipedia:Olfactory_bulb#Main_olfactory_bulb is_a: UBERON:0002616 ! regional part of brain relationship: BFO:0000050 UBERON:0002264 {source="cjm"} ! part of olfactory bulb property_value: skos:prefLabel "main olfactory bulb" xsd:string [Term] id: UBERON:0009953 name: post-embryonic organism def: "A multicellular organism that existence_starts_with a post-embryonic stage." [OBOL:automatic] synonym: "post-hatching organism" NARROW [https://orcid.org/0000-0002-6601-2165] synonym: "post-natal organism" NARROW [https://orcid.org/0000-0002-6601-2165] synonym: "postnatal mouse" NARROW [MA:0002405] synonym: "postnatal organism" EXACT [] synonym: "TS28 mouse" NARROW [MA:0002405] xref: MA:0002405 is_a: UBERON:0000468 ! multicellular organism intersection_of: UBERON:0000468 ! multicellular organism intersection_of: RO:0002489 UBERON:0000092 ! existence starts with post-embryonic stage relationship: RO:0002489 UBERON:0000092 ! existence starts with post-embryonic stage property_value: seeAlso "https://github.com/obophenotype/uberon/issues/667" xsd:anyURI property_value: skos:prefLabel "post-embryonic organism" xsd:string [Term] id: UBERON:0009954 name: vomeronasal system def: "A vertebrate nasal chemosensory system that is responsible for detecting intraspecific pheromonal cues as well as environmental odorants." [http://orcid.org/0000-0002-6601-2165] is_a: UBERON:0001032 ! sensory system relationship: BFO:0000050 UBERON:0005725 ! part of olfactory system relationship: RO:0002162 NCBITaxon:8287 ! in taxon Sarcopterygii relationship: RO:0002215 GO:0043695 {source="Wikipedia"} ! capable of detection of pheromone property_value: IAO:0000116 "check relationship to olfactory system. Evolution: The morphological components of the VNS are found only in tetrapods, but the genetic components of the system have been found in teleost fish, in addition to tetrapods. In tetrapods, the VNS was thought to be the olfactory system for detecting pheromones, while the main olfactory system detected general odorants (Scalia and Winans 1975). However, experimental evidence suggests that there is not such a clear functional distinction (Restrepo et al. 2004; Baxi, Dorries, and Eisthen 2006; Spehr et al. 2006; Kelliher 2007). Sea lampreys produce unique bile acids which act as pheromones both in migration and mate finding (Li, Sorensen, and Gallaher 1995; Li et al. 2002; Siefkes and Li 2004). However, bile acids in teleost fish are known to require components of the main olfactory signal transduction pathway (Hansen et al. 2003), and interruption of the VNS signal transduction pathway had no effect on bile acid olfactory response (Hansen et al. 2003)[Grus - EVOLUTION OF THE VOMERONASAL SYSTEM VIEWED THROUGH SYSTEM-SPECIFIC GENES]" xsd:string property_value: skos:prefLabel "vomeronasal system" xsd:string [Term] id: UBERON:0009955 name: neurogenic placode def: "Cranial ectodermal placode with potential to develop into a component of the nervous system, such as nerves or ganglia." [http://orcid.org/0000-0002-6601-2165, PMID:11523831] subset: efo_slim synonym: "neurogenic placodes" EXACT OMO:0003004 [ZFA:0001309] synonym: "placodae neurogenicae" RELATED OMO:0003011 [Wikipedia:Neurogenic_placodes] xref: EFO:0003460 xref: TAO:0001309 xref: Wikipedia:Neurogenic_placodes xref: XAO:0004620 xref: ZFA:0001309 is_a: BFO:0000002 is_a: UBERON:0002546 {source="cjm"} ! cranial placode intersection_of: UBERON:0005085 ! ectodermal placode intersection_of: RO:0002385 CL:0000540 ! has potential to developmentally contribute to neuron intersection_of: RO:0002385 UBERON:0001714 ! has potential to developmentally contribute to cranial ganglion intersection_of: RO:0002385 UBERON:0001785 ! has potential to developmentally contribute to cranial nerve disjoint_from: UBERON:0011814 ! non-neurogenic ectodermal placode relationship: RO:0002202 UBERON:2007013 ! develops from preplacodal ectoderm relationship: RO:0002385 CL:0000540 ! has potential to developmentally contribute to neuron relationship: RO:0002385 UBERON:0001714 ! has potential to developmentally contribute to cranial ganglion relationship: RO:0002385 UBERON:0001785 ! has potential to developmentally contribute to cranial nerve property_value: skos:prefLabel "neurogenic placode" xsd:string [Term] id: UBERON:0009958 name: bladder lumen def: "An anatomical space that is enclosed by a urinary bladder." [OBOL:automatic] synonym: "bladder cavity" EXACT [FMA:15924] synonym: "cavity of urinary bladder" EXACT [FMA:15924] synonym: "lumen of urinary bladder" EXACT [FMA:15924] synonym: "urinary bladder lumen" EXACT [FMA:15924] xref: EHDAA2:0004058 xref: FMA:15924 xref: galen:UrinaryBladderCavity xref: SCTID:279405003 is_a: BFO:0000002 is_a: UBERON:0000464 ! anatomical space intersection_of: UBERON:0000464 {source="FMA"} ! anatomical space intersection_of: RO:0002572 UBERON:0001255 {source="FMA"} ! luminal space of urinary bladder relationship: RO:0002202 UBERON:0009844 {source="EHDAA2"} ! develops from urogenital sinus lumen relationship: RO:0002572 UBERON:0001255 ! luminal space of urinary bladder [Term] id: UBERON:0009960 name: esophagus smooth muscle circular layer def: "A circular muscle layer of muscular coat that is part of a esophagus." [OBOL:automatic] synonym: "circular muscle layer of esophagus" EXACT [FMA:67605] synonym: "esophagus smooth muscle circular layer" RELATED [MA:0001574] synonym: "inner circular muscle layer of esophagus" EXACT [FMA:67605] xref: EMAPA:37523 {source="MA:th"} xref: FMA:67605 xref: MA:0001574 is_a: UBERON:0012368 ! circular muscle layer of muscular coat intersection_of: UBERON:0012368 ! circular muscle layer of muscular coat intersection_of: BFO:0000050 UBERON:0001043 ! part of esophagus relationship: BFO:0000050 UBERON:0002112 {source="MA"} ! part of smooth muscle of esophagus [Term] id: UBERON:0009966 name: internodal tract def: "A conducting pathway in the conducting tissue of heart through which electrical activity spreads from the SA node to the AV node." [Wikipedia:Electrical_conduction_system_of_the_heart] subset: human_reference_atlas synonym: "interatrial conduction tract" EXACT [] synonym: "internodal conduction tract" EXACT [] synonym: "internodal fasciculus" EXACT [FMA:9479] synonym: "internodal tract muscle tissue" EXACT [FMA:9479] xref: FMA:9479 is_a: UBERON:0004493 ! cardiac muscle tissue of myocardium is_a: UBERON:0010131 {source="cjm"} ! conducting tissue of heart relationship: BFO:0000050 UBERON:0002350 {source="FMA"} ! part of conducting system of heart property_value: IAO:0000116 "include 3 subtypes?" xsd:string property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0009967 name: spleen venous sinus synonym: "sinus lienalis" EXACT OMO:0003011 [FMA:TA] synonym: "sinus splenicus" EXACT OMO:0003011 [FMA:TA] synonym: "splenic sinus" EXACT [FMA:62815] synonym: "venous sinus of red pulp of spleen" EXACT [FMA:62815] xref: EMAPA:37751 {source="MA:th"} xref: FMA:62815 xref: MA:0000761 xref: NCIT:C33605 xref: UMLS:C1179415 {source="ncithesaurus:Splenic_Sinus"} is_a: UBERON:0003497 ! abdomen blood vessel is_a: UBERON:0006615 {source="cjm"} ! venous sinus relationship: BFO:0000050 UBERON:0001250 {source="MA"} ! part of red pulp of spleen property_value: seeAlso UBERON:0003910 [Term] id: UBERON:0009969 name: statoacoustic epithelium synonym: "stato-acoustic epithelium" EXACT [FMA:64804] xref: FMA:64804 is_a: UBERON:0006934 {source="FMA"} ! sensory epithelium [Term] id: UBERON:0009970 name: epithelium of pancreatic duct def: "An epithelium that is part of a pancreatic duct." [OBOL:automatic] subset: efo_slim synonym: "pancreatic duct epithelium" EXACT [FMA:67681] synonym: "pancreatic ductal epithelium" EXACT [FMA:67681] xref: EFO:0002556 xref: FMA:67681 is_a: UBERON:0010371 ! ecto-epithelium is_a: UBERON:0013697 ! exocrine pancreas epithelium is_a: UBERON:0034969 ! epithelial layer of duct intersection_of: UBERON:0000483 ! epithelium intersection_of: BFO:0000050 UBERON:0007329 ! part of pancreatic duct relationship: BFO:0000050 UBERON:0007329 ! part of pancreatic duct property_value: IAO:0000116 "in EHDAA2, the embryonic pancreatic ducts (dorsal, ventral) are classified as eithelial sacs, which would render them subclasses of this" xsd:string property_value: skos:prefLabel "epithelium of pancreatic duct" xsd:string [Term] id: UBERON:0009971 name: principal gastric gland def: "One of the gastric glands that secretes the hydrochloric acid of the gastric juice[Stedman's]." [http://www.drugs.com/dict/acid-gland.html, MP:0003892] synonym: "acid gland" EXACT [http://www.drugs.com/dict/acid-gland.html] synonym: "gastric follicle" RELATED [MP:0003892] synonym: "gastric gland" BROAD [MP:0003892] synonym: "glandula gastrica propria" EXACT [FMA:14921] synonym: "main gastric gland" EXACT [FMA:14921] synonym: "oxyntic gland" EXACT [FMA:14921] synonym: "principal gland of fundus of stomach" EXACT [FMA:14923] synonym: "Wassman gland" RELATED [MP:0003892] xref: FMA:14921 xref: FMA:14923 is_a: UBERON:0000325 {source="FMA"} ! gastric gland [Term] id: UBERON:0009972 name: ureteropelvic junction def: "The junction between the ureter and the renal pelvis of the kidney." [MP:0011487] subset: pheno_slim synonym: "pelviureteric junction" EXACT [FMA:15898] synonym: "pelvoureteric junction" EXACT [] xref: EMAPA:37782 {source="MA:th"} xref: FMA:15898 xref: MA:0003021 xref: NCIT:C106203 xref: SCTID:264130006 is_a: UBERON:0007651 ! anatomical junction intersection_of: UBERON:0007651 ! anatomical junction intersection_of: RO:0002176 UBERON:0000056 ! connects ureter intersection_of: RO:0002176 UBERON:0001224 ! connects renal pelvis relationship: BFO:0000050 UBERON:0001008 {source="MP"} ! part of renal system relationship: RO:0002176 UBERON:0000056 ! connects ureter relationship: RO:0002176 UBERON:0001224 ! connects renal pelvis relationship: RO:0002433 UBERON:0001008 ! contributes to morphology of renal system [Term] id: UBERON:0009973 name: ureterovesical junction def: "The valve-like structure found at the site of entry of the ureter into the urinary bladder, normally displays an oblique angulation through the detrusor to avoid reflux of urine up the ureters and the kidney." [MP:0011488] subset: pheno_slim synonym: "vesico-ureteral junction" EXACT [MA:0003020] synonym: "vesico-ureteric junction" EXACT [] synonym: "vesicoureteric junction" EXACT [] xref: EMAPA:37783 {source="MA:th"} xref: FMA:15899 xref: MA:0003020 xref: NCIT:C106202 xref: SCTID:261187001 is_a: UBERON:0003978 ! valve is_a: UBERON:0007651 ! anatomical junction intersection_of: UBERON:0007651 ! anatomical junction intersection_of: RO:0002176 UBERON:0000056 ! connects ureter intersection_of: RO:0002176 UBERON:0001255 ! connects urinary bladder relationship: BFO:0000050 UBERON:0001008 {source="MP"} ! part of renal system relationship: RO:0002176 UBERON:0000056 ! connects ureter relationship: RO:0002176 UBERON:0001255 ! connects urinary bladder relationship: RO:0002433 UBERON:0001008 ! contributes to morphology of renal system [Term] id: UBERON:0009974 name: lumen of Rathke's pouch def: "An anatomical cavity that surrounded_by a Rathke's pouch." [OBOL:automatic] synonym: "Rathkes pouch invagination" NARROW [EHDAA2:0004138] xref: EHDAA2:0004138 xref: EMAPA:25037 is_a: UBERON:0005082 {source="EHDAA2"} ! tube lumen is_a: UBERON:0007473 ! lumen of epithelial sac intersection_of: UBERON:0000464 ! anatomical space intersection_of: RO:0002572 UBERON:0005356 ! luminal space of Rathke's pouch relationship: RO:0002219 UBERON:0012287 {source="EHDAA2-modified"} ! surrounded by Rathkes pouch epithelium relationship: RO:0002572 UBERON:0005356 ! luminal space of Rathke's pouch property_value: skos:prefLabel "lumen of Rathke's pouch" xsd:string [Term] id: UBERON:0010000 name: multicellular anatomical structure def: "An anatomical structure that has more than one cell as a part." [CARO:0010000] subset: common_anatomy subset: upper_level synonym: "multicellular structure" EXACT [FBbt:00100313] xref: CARO:0010000 xref: FBbt:00100313 {sssom:mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"} is_a: UBERON:0000061 ! anatomical structure intersection_of: UBERON:0000061 ! anatomical structure intersection_of: RO:0000086 PATO:0001993 ! has quality multicellular relationship: BFO:0000051 CL:0000000 ! has part cell relationship: RO:0000086 PATO:0001993 ! has quality multicellular property_value: RO:0002175 NCBITaxon:33090 property_value: RO:0002175 NCBITaxon:33208 property_value: RO:0002175 NCBITaxon:4751 property_value: skos:prefLabel "multicellular anatomical structure" xsd:string [Term] id: UBERON:0010001 name: cell cluster organ def: "A small cluster of cells of various types which form a discrete structure, largely delimited by a morphological boundary and whose components work together to make the whole structure capable of a specific function." [CARO:0010001] comment: Examples include arthropod sensilla. subset: upper_level xref: CARO:0010001 xref: FBbt:00007229 {sssom:mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"} is_a: UBERON:0000062 {source="CARO"} ! organ is_a: UBERON:0034922 {source="CARO"} ! cell cluster disjoint_from: UBERON:0011216 {source="FBbt"} ! organ system subdivision [Term] id: UBERON:0010005 name: placental labyrinth villous def: "The vascularized and branched structures arising from the rodent trophoblast-derived epithelium that allow an increase its surface area for the efficient exchange of nutrients and wastes between the maternal and fetal circulation." [MP:0011522] subset: pheno_slim synonym: "placental labyrinth villi" RELATED OMO:0003004 [] synonym: "villous of placental labyrinth" EXACT [] is_a: UBERON:0000061 ! anatomical structure relationship: BFO:0000050 UBERON:0003946 {source="MP"} ! part of placenta labyrinth relationship: RO:0002433 UBERON:0003946 ! contributes to morphology of placenta labyrinth [Term] id: UBERON:0010009 name: aggregate regional part of brain def: "A regional part of brain consisting of multiple brain regions that are not related through a simple volummetric part of hierarchy, e.g., basal ganglia[NIF]." [NLXANAT:20090509] subset: non_informative synonym: "set of nuclei of neuraxis" RELATED [FMA:256381] xref: NLXANAT:20090509 is_a: BFO:0000002 is_a: BFO:0000004 is_a: UBERON:0034923 ! disconnected anatomical group intersection_of: UBERON:0034923 ! disconnected anatomical group intersection_of: BFO:0000050 UBERON:0000955 ! part of brain intersection_of: RO:0002351 UBERON:0002616 ! has member regional part of brain relationship: BFO:0000050 UBERON:0000955 ! part of brain relationship: RO:0002351 UBERON:0002616 ! has member regional part of brain property_value: IAO:0000116 "May be obsoleted." xsd:string property_value: skos:prefLabel "aggregate regional part of brain" xsd:string [Term] id: UBERON:0010011 name: collection of basal ganglia def: "Subcortical masses of gray matter in the forebrain and midbrain that are richly interconnected and so viewed as a functional system. The nuclei usually included are the caudate nucleus (caudoputamen in rodents), putamen, globus pallidus, substantia nigra (pars compacta and pars reticulata) and the subthalamic nucleus. Some also include the nucleus accumbens and ventral pallidum." [BIRNLEX:826] subset: human_reference_atlas subset: pheno_slim synonym: "basal ganglia" EXACT [FMA:84013] synonym: "basal ganglia set" EXACT [FMA:84013] synonym: "basal nuclei" RELATED [] synonym: "basal nuclei (basal ganglia)" EXACT [PBA:BN] synonym: "cerebral nuclei" RELATED [NeuroNames:2677] synonym: "set of basal ganglia" EXACT [FMA:84013] synonym: "set of basal nuclei" RELATED [FMA:84013] synonym: "subcortical nuclei" RELATED [NeuroNames:2677] xref: BAMS:BG xref: BIRNLEX:826 xref: BM:Tel-BG xref: EMAPA:32673 xref: FMA:84013 xref: GAID:617 xref: HBA:4276 xref: MA:0000184 xref: MBA:623 xref: MESH:D001479 xref: NCIT:C12447 xref: neuronames:2677 xref: PBA:4001 xref: UMLS:C0004781 {source="ncithesaurus:Basal_Ganglia"} xref: VHOG:0001696 xref: Wikipedia:Basal_ganglia is_a: UBERON:0010009 {source="FMA"} ! aggregate regional part of brain relationship: BFO:0000050 UBERON:0000454 {source="FMA"} ! part of cerebral subcortex relationship: RO:0002131 UBERON:0001891 ! overlaps midbrain relationship: RO:0002131 UBERON:0001893 {source="MA", source="NIF"} ! overlaps telencephalon property_value: IAO:0000116 "it is necessary to introduce two classes, one representing an individual basal ganglion, another representing the aggregate structure, in order to have consistent classification amongst AOs (e.g. in MA the aygdala is part of the BG, in FMA and BTO it is a subclass). Apart from achieving this consistency, the value of having two distinct classes is questionable, since the BG-plural is trivially the collection of all BGs-singular. it would be better for all AOs to decide on one single way of doing this. Do not merge until this is done." xsd:string property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "collection of basal ganglia" xsd:string [Term] id: UBERON:0010020 name: tubotympanic recess epithelium def: "The dorsal portion of the embryonic first endodermal pharyngeal pouch; it develops into the middle ear cavity." [ISBN:0124020607, VHOG:0001297] synonym: "tubotympanic recess" RELATED [VHOG:0001297] xref: EHDAA2:0004115 xref: EHDAA:6772 xref: EMAPA:17002 xref: MA:0001218 xref: NCIT:C34318 xref: SCTID:361516008 xref: UMLS:C1284046 {source="ncithesaurus:Tubotympanic_Recess"} xref: VHOG:0001297 is_a: UBERON:0005423 ! developing anatomical structure is_a: UBERON:0005911 ! endo-epithelium is_a: UBERON:0007499 {source="EHDAA2"} ! epithelial sac is_a: UBERON:0015813 ! middle ear epithelium relationship: RO:0002202 UBERON:0007122 {source="EHDAA2", source="ISBN:0073040584", source="PMID:11237469"} ! develops from pharyngeal pouch 1 [Term] id: UBERON:0010025 name: dorsal part of pharyngeal pouch 3 synonym: "cranial dorsal aspect of third dorsal pharyngeal pouch" RELATED [] synonym: "dorsal 3rd arch pharyngeal pouch endoderm" EXACT [EHDAA2:0000409] synonym: "dorsal 3rd branchial pouch" EXACT [] synonym: "dorsal branchial pouch 3 endoderm" RELATED [] synonym: "dorsal pharyngeal pouch 3" EXACT [] synonym: "dorsal pharyngeal pouch 3 endoderm" RELATED [] synonym: "dorsal wing of pharyngeal pouch 3" EXACT [http://orcid.org/0000-0002-6601-2165] xref: EHDAA2:0000409 xref: EMAPA:16758 is_a: UBERON:0000490 {source="EHDAA2"} ! unilaminar epithelium is_a: UBERON:0005291 ! embryonic tissue is_a: UBERON:0015833 ! foregut epithelium relationship: BFO:0000050 UBERON:0007124 {source="EHDAA2"} ! part of pharyngeal pouch 3 [Term] id: UBERON:0010026 name: ventral part of pharyngeal pouch 3 synonym: "caudal ventral aspect of third dorsal pharyngeal pouch" RELATED [] synonym: "ventral 3rd arch pharyngeal pouch endoderm" EXACT [EHDAA2:0002173] synonym: "ventral 3rd branchial pouch" EXACT [] synonym: "ventral branchial pouch 3 endoderm" RELATED [] synonym: "ventral pharyngeal pouch 3" EXACT [] synonym: "ventral pharyngeal pouch 3 endoderm" RELATED [] synonym: "ventral wing of pharyngeal pouch 3" EXACT [http://orcid.org/0000-0002-6601-2165] xref: EHDAA2:0002173 xref: EMAPA:16759 is_a: UBERON:0000490 {source="EHDAA2"} ! unilaminar epithelium is_a: UBERON:0005291 ! embryonic tissue is_a: UBERON:0015833 ! foregut epithelium relationship: BFO:0000050 UBERON:0007124 {source="EHDAA2"} ! part of pharyngeal pouch 3 [Term] id: UBERON:0010027 name: dorsal part of pharyngeal pouch 4 synonym: "dorsal 4th branchial pouch" EXACT [] synonym: "dorsal branchial pouch 4 endoderm" RELATED [] synonym: "dorsal pharyngeal pouch 4" EXACT [] synonym: "dorsal pharyngeal pouch 4 endoderm" RELATED [] is_a: UBERON:0000490 ! unilaminar epithelium is_a: UBERON:0005291 ! embryonic tissue is_a: UBERON:0015833 ! foregut epithelium relationship: BFO:0000050 UBERON:0007125 ! part of pharyngeal pouch 4 [Term] id: UBERON:0010028 name: ventral part of pharyngeal pouch 4 synonym: "ventral 4th branchial pouch" EXACT [] synonym: "ventral branchial pouch 4 endoderm" RELATED [] synonym: "ventral pharyngeal pouch 4" EXACT [] synonym: "ventral pharyngeal pouch 4 endoderm" RELATED [] is_a: UBERON:0000490 ! unilaminar epithelium is_a: UBERON:0005291 ! embryonic tissue is_a: UBERON:0015833 ! foregut epithelium relationship: BFO:0000050 UBERON:0007125 ! part of pharyngeal pouch 4 [Term] id: UBERON:0010031 name: 6th arch mesenchyme def: "Mesenchyme that is part of a pharyngeal arch 6." [OBOL:automatic] synonym: "6th branchial arch mesenchyme" RELATED [] synonym: "6th pharyngeal arch mesenchyme" EXACT [] synonym: "pharyngeal arch 6 mesenchyme" RELATED [] xref: EHDAA2:0004076 xref: EMAPA:32765 xref: FMA:318209 is_a: UBERON:0009494 ! pharyngeal arch mesenchymal region intersection_of: UBERON:0003104 ! mesenchyme intersection_of: BFO:0000050 UBERON:0003117 ! part of pharyngeal arch 6 relationship: BFO:0000050 UBERON:0003117 ! part of pharyngeal arch 6 property_value: skos:prefLabel "6th arch mesenchyme" xsd:string [Term] id: UBERON:0010032 name: anterior part of tongue def: "The portion of the tongue in front of the terminal sulcus. At the apex, thin and narrow, it is directed forward against the lingual surfaces of the lower incisor teeth. It is derived primarily from the first pharyngeal arch." [Wikipedia:Anterior_tongue] subset: human_reference_atlas synonym: "anterior 2/3 of the tongue" RELATED [Wikipedia:Anterior_tongue] synonym: "anterior 2/3 of tongue" RELATED [Wikipedia:Anterior_tongue] synonym: "anterior two thirds of the tongue" RELATED [Wikipedia:Anterior_tongue] synonym: "apex linguae" RELATED [Wikipedia:Anterior_tongue] synonym: "apex of the tongue" RELATED [Wikipedia:Anterior_tongue] synonym: "buccal part of the tongue" RELATED [Wikipedia:Anterior_tongue] synonym: "front of the tongue" RELATED [Wikipedia:Anterior_tongue] synonym: "oral part of the tongue" RELATED [Wikipedia:Anterior_tongue] synonym: "pars anterior dorsi linguae" RELATED OMO:0003011 [Wikipedia:Anterior_tongue] xref: EMAPA:37437 {source="MA:th"} xref: FMA:229084 xref: NCIT:C32130 xref: UMLS:C0226946 {source="ncithesaurus:Apex_of_the_Tongue"} xref: Wikipedia:Anterior_tongue is_a: BFO:0000002 is_a: UBERON:0000064 ! organ part intersection_of: UBERON:0000064 {source="ISBN:1607950324"} ! organ part intersection_of: BFO:0000050 UBERON:0001723 {source="ISBN:1607950324"} ! part of tongue intersection_of: RO:0002202 UBERON:0006260 {source="ISBN:1607950324"} ! develops from lingual swellings relationship: BFO:0000050 UBERON:0001723 ! part of tongue relationship: RO:0002202 UBERON:0006260 ! develops from lingual swellings property_value: foaf:depiction "https://upload.wikimedia.org/wikipedia/commons/4/4c/Illu04_tongue.jpg" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "anterior part of tongue" xsd:string [Term] id: UBERON:0010038 name: fundic gastric gland def: "The fundus glands (or fundic glands, or gastric glands) are found in the body and fundus of the stomach. They are simple tubes, two or more of which open into a single duct." [Wikipedia:Fundic_glands] synonym: "fundal gland" EXACT [] synonym: "fundus gland" EXACT [] synonym: "gastric fundal gland" EXACT [] synonym: "gastric fundus gland" EXACT [] synonym: "gastric gland of fundus of stomach" EXACT [] synonym: "glandulae gastricae" RELATED OMO:0003011 [Wikipedia:Fundic_glands] xref: EMAPA:27161 xref: NCIT:C32643 xref: SCTID:268338004 xref: UMLS:C0017130 {source="ncithesaurus:Fundic_Gland"} xref: Wikipedia:Fundic_glands is_a: BFO:0000002 is_a: UBERON:0000325 ! gastric gland is_a: UBERON:0000414 ! mucous gland intersection_of: UBERON:0000325 ! gastric gland intersection_of: BFO:0000050 UBERON:0001160 ! part of fundus of stomach relationship: BFO:0000050 UBERON:0004994 ! part of mucosa of fundus of stomach relationship: BFO:0000051 CL:0000155 {source="ISBN:0073040584"} ! has part peptic cell relationship: BFO:0000051 CL:0000162 {source="ISBN:0073040584"} ! has part parietal cell property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/d/d7/Fundic_gland_polyp_%281%29.jpg" xsd:anyURI property_value: IAO:0000116 "Consider FMA:14923 ! Principal gland of fundus of stomach. Added part_of to mucosa to be consistent with FMA pattern (note that Kardong places this in the glandular epithelium)" xsd:string [Term] id: UBERON:0010039 name: food storage organ def: "An organ of the digestive tract that is capable of retaining and storing food." [https://orcid.org/0000-0002-6601-2165] subset: functional_classification subset: grouping_class xref: BSA:0000123 xref: TADS:0000172 xref: TGMA:0001041 is_a: UBERON:0013765 ! digestive system element relationship: BFO:0000050 UBERON:0001555 ! part of digestive tract relationship: BFO:0000050 UBERON:0005409 ! part of alimentary part of gastrointestinal system property_value: skos:prefLabel "food storage organ" xsd:string [Term] id: UBERON:0010042 name: 1st arch mesenchyme def: "Mesenchyme that is part of a pharyngeal arch 1." [OBOL:automatic] synonym: "mesenchyme of 1st arch" EXACT [EMAPA:16128] xref: EMAPA:16128 is_a: UBERON:0009494 ! pharyngeal arch mesenchymal region intersection_of: UBERON:0003104 ! mesenchyme intersection_of: BFO:0000050 UBERON:0004362 ! part of pharyngeal arch 1 relationship: BFO:0000050 UBERON:0004362 ! part of pharyngeal arch 1 property_value: skos:prefLabel "1st arch mesenchyme" xsd:string [Term] id: UBERON:0010045 name: 1st arch maxillary mesenchyme def: "Mesenchyme that is part of a 1st arch maxillary component." [OBOL:automatic] synonym: "maxillary component mesenchyme" RELATED [] synonym: "maxillary mesenchyme" RELATED [] synonym: "mesenchyme of maxillary component" EXACT [EMAPA:16391] xref: EHDAA2:0000041 xref: EMAPA:16391 is_a: UBERON:0010042 ! 1st arch mesenchyme intersection_of: UBERON:0003104 ! mesenchyme intersection_of: BFO:0000050 UBERON:0007238 ! part of 1st arch maxillary component relationship: BFO:0000050 UBERON:0007238 ! part of 1st arch maxillary component property_value: skos:prefLabel "1st arch maxillary mesenchyme" xsd:string [Term] id: UBERON:0010046 name: entire pharyngeal arch associated mesenchyme def: "The sum total of mesenchymal tissue in the pharyngeal arch region. Pharyngeal mesenchyme is undifferentiated, loose connective tissue derived mostly from mesoderm, and also contains ectodermally derived neural crest cells." [https://orcid.org/0000-0002-6601-2165, XAO:0004524] synonym: "associated mesenchyme of pharyngeal region" EXACT [EMAPA:16550] synonym: "entire branchial arch associated mesenchyme" EXACT [https://orcid.org/0000-0002-6601-2165] synonym: "pharyngeal arch associated mesenchyme" EXACT [EHDAA2:0001459] xref: EHDAA2:0001459 xref: EMAPA:16550 xref: XAO:0004524 is_a: UBERON:0005291 ! embryonic tissue is_a: UBERON:0007524 {source="EHDAA2"} ! dense mesenchyme tissue relationship: BFO:0000050 UBERON:0008814 {source="EHDAA2"} ! part of pharyngeal arch system relationship: RO:0002254 UBERON:0003099 {source="cjm"} ! has developmental contribution from cranial neural crest property_value: skos:prefLabel "entire pharyngeal arch associated mesenchyme" xsd:string [Term] id: UBERON:0010047 name: oral gland def: "Gland of the epithelium lining the oral cavity. The most common are the salivary glands." [ISBN:0073040584] subset: human_reference_atlas synonym: "buccal gland" NARROW [] synonym: "gland of oral opening" RELATED [] synonym: "gland of oral region" RELATED [] synonym: "mouth gland" RELATED [] synonym: "oral cavity gland" RELATED [] synonym: "oral region gland" RELATED [] xref: EHDAA2:0001327 xref: EHDAA:2181 xref: EMAPA:16572 xref: EMAPA:16723 xref: VHOG:0000652 is_a: UBERON:0002365 ! exocrine gland is_a: UBERON:0003408 ! gland of digestive tract intersection_of: UBERON:0002530 ! gland intersection_of: BFO:0000050 UBERON:0000165 ! part of mouth relationship: BFO:0000050 UBERON:0000165 ! part of mouth property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "oral gland" xsd:string [Term] id: UBERON:0010052 name: mucosa of dorsum of tongue def: "A mucosa that is part of a dorsum of tongue." [OBOL:automatic] synonym: "mucosa of dorsal surface of tongue" EXACT [] xref: FMA:74871 xref: SCTID:245835003 is_a: UBERON:0005020 ! mucosa of tongue intersection_of: UBERON:0000344 ! mucosa intersection_of: BFO:0000050 UBERON:0009471 ! part of dorsum of tongue relationship: BFO:0000050 UBERON:0009471 ! part of dorsum of tongue property_value: IAO:0000116 "check surface terms" xsd:string property_value: skos:prefLabel "mucosa of dorsum of tongue" xsd:string [Term] id: UBERON:0010056 name: future tongue def: "A compound organ that has the potential to develop into a tongue." [OBOL:automatic] xref: EHDAA2:0000696 xref: EHDAA:2951 is_a: UBERON:0003103 {source="EHDAA2"} ! compound organ is_a: UBERON:0005423 ! developing anatomical structure is_a: UBERON:0013765 ! digestive system element intersection_of: UBERON:0003103 ! compound organ intersection_of: RO:0002387 UBERON:0001723 ! has potential to develop into tongue relationship: BFO:0000050 UBERON:0000165 ! part of mouth relationship: RO:0002387 UBERON:0001723 ! has potential to develop into tongue property_value: skos:prefLabel "future tongue" xsd:string [Term] id: UBERON:0010059 name: hypoglossal cord xref: EHDAA2:0004610 is_a: UBERON:0002036 {source="EHDAA2"} ! striated muscle tissue relationship: BFO:0000050 UBERON:0010056 {source="EHDAA2"} ! part of future tongue property_value: skos:prefLabel "hypoglossal cord" xsd:string [Term] id: UBERON:0010060 name: pharyngeal opening of pharyngotympanic tube def: "On the lateral wall of the nasal part of the pharynx is the pharyngeal opening of auditory tube (pharyngeal ostium), somewhat triangular in shape, and bounded behind by a firm prominence, the torus or cushion, caused by the medial end of the cartilage of the tube which elevates the mucous membrane." [Wikipedia:Pharyngeal_opening_of_auditory_tube] synonym: "ostium pharyngeum tubae auditivae" EXACT OMO:0003011 [FMA:TA] synonym: "ostium pharyngeum tubae auditivae" RELATED OMO:0003011 [Wikipedia:Pharyngeal_opening_of_auditory_tube] synonym: "ostium pharyngeum tubae auditoriae" EXACT OMO:0003011 [FMA:TA] synonym: "pharyngeal opening of auditory tube" EXACT [FMA:54979] synonym: "pharyngeal opening of eustachian tube" EXACT [FMA:54979] synonym: "pharyngeal orifice of auditory tube" EXACT [FMA:54979] synonym: "pharyngeal orifice of eustachian tube" EXACT [FMA:54979] synonym: "pharyngeal orifice of pharyngotympanic tube" EXACT [FMA:54979] synonym: "pharyngeal ostium" RELATED [Wikipedia:Pharyngeal_opening_of_auditory_tube] synonym: "pharyngeal ostium of auditory tube" EXACT [FMA:54979] synonym: "pharyngeal ostium of eustachian tube" EXACT [FMA:54979] synonym: "pharyngeal ostium of pharyngotympanic tube" EXACT [FMA:54979] synonym: "pharyngeal tubal ostium" EXACT [FMA:54979] xref: FMA:54979 xref: SCTID:368945008 xref: Wikipedia:Pharyngeal_opening_of_auditory_tube is_a: UBERON:0000464 ! anatomical space relationship: BFO:0000050 UBERON:0001042 ! part of chordate pharynx relationship: RO:0002150 UBERON:0010061 ! continuous with lumen of nasopharynx property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/1/1b/Gray1029.png" xsd:anyURI [Term] id: UBERON:0010061 name: lumen of nasopharynx synonym: "nasopharyngeal luman" EXACT [] synonym: "nasopharynx cavity" EXACT [] synonym: "nasopharynx lumen" EXACT [FMA:55094] xref: FMA:55094 is_a: UBERON:0000464 ! anatomical space relationship: BFO:0000050 UBERON:0001728 ! part of nasopharynx relationship: BFO:0000050 UBERON:0001731 ! part of cavity of pharynx [Term] id: UBERON:0010062 name: pharyngotympanic tube epithelium synonym: "auditory tube epithelium" EXACT [EHDAA2:0004117] synonym: "eustachian tube epithelium" EXACT [https://orcid.org/0000-0002-6601-2165] xref: EHDAA2:0004117 xref: EMAPA:32801 xref: FMA:285217 xref: MA:0003142 is_a: UBERON:0003914 {source="EHDAA2"} ! epithelial tube is_a: UBERON:0005911 ! endo-epithelium is_a: UBERON:0015813 ! middle ear epithelium relationship: BFO:0000050 UBERON:0002393 {source="cjm"} ! part of pharyngotympanic tube relationship: RO:0002225 UBERON:0010020 {source="EHDAA2"} ! develops from part of tubotympanic recess epithelium [Term] id: UBERON:0010063 name: tympanic cavity epithelium xref: EHDAA2:0004116 is_a: UBERON:0005911 ! endo-epithelium is_a: UBERON:0007499 {source="EHDAA2"} ! epithelial sac is_a: UBERON:0015813 ! middle ear epithelium relationship: RO:0001025 UBERON:0004114 ! located in tympanic cavity relationship: RO:0002225 UBERON:0010020 {source="EHDAA2"} ! develops from part of tubotympanic recess epithelium [Term] id: UBERON:0010064 name: open anatomical space def: "An anatomical space with at least one opening to another space or the exterior." [AEO:0000221] xref: AEO:0000221 xref: EHDAA2:0004616 is_a: UBERON:0000464 ! anatomical space intersection_of: UBERON:0000464 ! anatomical space intersection_of: RO:0000086 PATO:0000610 ! has quality open relationship: RO:0000086 PATO:0000610 ! has quality open relationship: RO:0002170 UBERON:0000464 {source="cjm"} ! connected to anatomical space [Term] id: UBERON:0010065 name: auditory meatus epithelium xref: EHDAA2:0004114 is_a: BFO:0000002 is_a: UBERON:0003914 {source="EHDAA2"} ! epithelial tube is_a: UBERON:0015814 ! outer ear epithelium relationship: RO:0002202 UBERON:0005872 {source="EHDAA2", source="PMID:16313389"} ! develops from 1st arch pharyngeal cleft [Term] id: UBERON:0010069 name: outer epithelial layer of tympanic membrane def: "A portion of the external acoustic meatus epithelium which makes up the outer (cuticular) layer of the tympanic membrane." [https://orcid.org/0000-0002-6601-2165, PMID:11237469] synonym: "cuticular layer of tympanic membrane" EXACT [FMA:56819] synonym: "cuticular stratum of tympanic membrane" EXACT [FMA:56819] synonym: "outer cuticular layer of tympanic membrane" EXACT [FMA:56819] synonym: "outer layer of tympanic membrane" EXACT [] synonym: "tympanic membrane external acoustic meatus epithelial component" EXACT [https://orcid.org/0000-0002-6601-2165] xref: FMA:56819 xref: SCTID:39725007 is_a: UBERON:0009647 ! tympanic membrane epithelium is_a: UBERON:0015814 ! outer ear epithelium intersection_of: UBERON:0009647 ! tympanic membrane epithelium intersection_of: BFO:0000050 UBERON:0001352 ! part of external acoustic meatus relationship: BFO:0000050 UBERON:0001352 ! part of external acoustic meatus [Term] id: UBERON:0010070 name: intermediate layer of tympanic membrane def: "The intermediate fibrous layer of the tympanic membrane." [https://sourceforge.net/tracker/?func=detail&aid=3468783&group_id=76834&atid=1205376, PMID:11237469] synonym: "connective tissue layer of tympanic membrane" EXACT [FMA:56830] synonym: "fibrous layer of tympanic membrane" EXACT [FMA:56830] synonym: "fibrous stratum of tympanic membrane" EXACT [FMA:56830] synonym: "intermediate fibrous layer of tympanic membrane" EXACT [FMA:56830] synonym: "tympanic endothelium" EXACT [MA:0001223] xref: EMAPA:19063 xref: FMA:56830 xref: MA:0001223 xref: SCTID:44692008 is_a: UBERON:0010071 {source="FMA"} ! layer of tympanic membrane [Term] id: UBERON:0010071 name: layer of tympanic membrane subset: grouping_class synonym: "tympanic membrane layer" EXACT [FMA:56732] xref: FMA:56732 is_a: UBERON:0000064 ! organ part relationship: BFO:0000050 UBERON:0002364 ! part of tympanic membrane [Term] id: UBERON:0010074 name: chromaffin system def: "Organ system subdivision that consists primarily of chromaffin cells and their supporting structures." [http://orcid.org/0000-0002-6601-2165] synonym: "argentaffin system" RELATED [MESH:A06.224] synonym: "chromaffin tissue" RELATED [] xref: FMA:79645 xref: MESH:D002838 is_a: UBERON:0010313 ! neural crest-derived structure is_a: UBERON:0011216 ! organ system subdivision relationship: BFO:0000050 UBERON:0000949 {source="cjm"} ! part of endocrine system relationship: RO:0002473 CL:0000166 ! composed primarily of chromaffin cell [Term] id: UBERON:0010075 name: sacral neural crest def: "One of the 5 distinct and partially overlapping functional domains of the premigratory neural crest. The vagal and sacral neural crest cells develop into the ganglia of the enteric nervous system, also known as the parasympathetic ganglia." [http://www.ncbi.nlm.nih.gov/books/NBK10065/, XB:curator] xref: XAO:0004192 is_a: UBERON:0005291 ! embryonic tissue relationship: BFO:0000050 UBERON:0002342 ! part of neural crest property_value: skos:prefLabel "sacral neural crest" xsd:string [Term] id: UBERON:0010077 name: cuboidal epithelium def: "An epithelium consisting of cuboidal epithelial cells." [Wikipedia:Cuboidal_epithelium] xref: NCIT:C32415 xref: UMLS:C0682577 {source="ncithesaurus:Cuboidal_Epithelium"} xref: Wikipedia:Cuboidal_epithelium is_a: UBERON:0000483 ! epithelium property_value: IAO:0000116 "TODO - coordinate with CL, add cuboidal cell" xsd:string property_value: skos:prefLabel "cuboidal epithelium" xsd:string [Term] id: UBERON:0010081 name: future common hepatic duct def: "An extrahepatic bile duct that has the potential to develop into a common hepatic duct." [OBOL:automatic] xref: EHDAA2:0000595 is_a: UBERON:0003703 ! extrahepatic bile duct is_a: UBERON:0003914 ! epithelial tube is_a: UBERON:0005911 ! endo-epithelium is_a: UBERON:0034932 ! epithelium of biliary system intersection_of: UBERON:0003703 ! extrahepatic bile duct intersection_of: RO:0002387 UBERON:0001175 ! has potential to develop into common hepatic duct relationship: RO:0002202 UBERON:0005604 ! develops from extrahepatic part of hepatic duct relationship: RO:0002387 UBERON:0001175 ! has potential to develop into common hepatic duct property_value: skos:prefLabel "future common hepatic duct" xsd:string [Term] id: UBERON:0010083 name: future dermis def: "Mesenchyme that has the potential to develop into a dermis." [OBOL:automatic] xref: EHDAA2:0000598 is_a: BFO:0000002 is_a: UBERON:0003104 ! mesenchyme intersection_of: UBERON:0003104 ! mesenchyme intersection_of: RO:0002387 UBERON:0002067 ! has potential to develop into dermis relationship: BFO:0000050 UBERON:0002199 {source="EHDAA2"} ! part of integument relationship: RO:0002202 UBERON:0003089 {source="EHDAA2"} ! develops from sclerotome relationship: RO:0002202 UBERON:0004016 {source="XAO"} ! develops from dermatome relationship: RO:0002387 UBERON:0002067 ! has potential to develop into dermis property_value: IAO:0000116 "check development" xsd:string property_value: skos:prefLabel "future dermis" xsd:string [Term] id: UBERON:0010084 name: future diaphragm def: "A structure that will develop into a diaphragm." [http://orcid.org/0000-0002-6601-2165] xref: EHDAA2:0000599 is_a: BFO:0000002 is_a: UBERON:0006598 ! presumptive structure intersection_of: UBERON:0006598 ! presumptive structure intersection_of: RO:0002387 UBERON:0001103 ! has potential to develop into diaphragm relationship: RO:0001025 UBERON:0002323 {source="EHDAA2"} ! located in coelemic cavity lumen relationship: RO:0002202 UBERON:0005594 {source="PMID:23586979"} ! develops from head somite relationship: RO:0002256 UBERON:0009133 {source="PMID:23586979"} ! developmentally induced by pleuroperitoneal membrane relationship: RO:0002387 UBERON:0001103 ! has potential to develop into diaphragm property_value: skos:prefLabel "future diaphragm" xsd:string [Term] id: UBERON:0010091 name: future hindbrain meninx def: "A multi-tissue structure that has the potential to develop into a meninx of hindbrain." [OBOL:automatic] synonym: "future hindbrain meninges" EXACT [EHDAA2:0000610] xref: EHDAA2:0000610 is_a: UBERON:0005291 ! embryonic tissue is_a: UBERON:0007524 ! dense mesenchyme tissue is_a: UBERON:0007645 ! future meninx intersection_of: UBERON:0006598 ! presumptive structure intersection_of: RO:0002387 UBERON:0003291 ! has potential to develop into meninx of hindbrain relationship: BFO:0000050 UBERON:0002028 ! part of hindbrain relationship: RO:0002387 UBERON:0003291 ! has potential to develop into meninx of hindbrain property_value: skos:prefLabel "future hindbrain meninx" xsd:string [Term] id: UBERON:0010092 name: future metencephalon def: "A developing anatomical structure that has the potential to develop into a metencephalon." [OBOL:automatic] xref: EHDAA2:0000623 is_a: UBERON:0006598 ! presumptive structure intersection_of: UBERON:0006598 ! presumptive structure intersection_of: RO:0002387 UBERON:0001895 ! has potential to develop into metencephalon relationship: BFO:0000050 UBERON:0002028 ! part of hindbrain relationship: RO:0002387 UBERON:0001895 ! has potential to develop into metencephalon property_value: skos:prefLabel "future metencephalon" xsd:string [Term] id: UBERON:0010096 name: future myelencephalon def: "A developing anatomical structure that has the potential to develop into a myelencephalon." [OBOL:automatic] xref: EHDAA2:0000640 is_a: UBERON:0006598 ! presumptive structure intersection_of: UBERON:0006598 ! presumptive structure intersection_of: RO:0002387 UBERON:0005290 ! has potential to develop into myelencephalon relationship: BFO:0000050 UBERON:0002028 ! part of hindbrain relationship: RO:0002387 UBERON:0005290 ! has potential to develop into myelencephalon property_value: skos:prefLabel "future myelencephalon" xsd:string [Term] id: UBERON:0010123 name: future facial nucleus def: "A gray matter that has the potential to develop into a facial nucleus." [OBOL:automatic] xref: EHDAA2:0004639 is_a: UBERON:0002020 ! gray matter intersection_of: UBERON:0002020 ! gray matter intersection_of: RO:0002387 UBERON:0000127 ! has potential to develop into facial nucleus relationship: RO:0002387 UBERON:0000127 ! has potential to develop into facial nucleus property_value: skos:prefLabel "future facial nucleus" xsd:string [Term] id: UBERON:0010125 name: future superior salivatory nucleus def: "A gray matter that has the potential to develop into a superior salivatory nucleus." [OBOL:automatic] xref: EHDAA2:0004644 is_a: UBERON:0002020 ! gray matter intersection_of: UBERON:0002020 ! gray matter intersection_of: RO:0002387 UBERON:0002149 ! has potential to develop into superior salivatory nucleus relationship: RO:0002387 UBERON:0002149 ! has potential to develop into superior salivatory nucleus property_value: skos:prefLabel "future superior salivatory nucleus" xsd:string [Term] id: UBERON:0010128 name: future pterygopalatine ganglion def: "A ganglion that has the potential to develop into a pterygopalatine ganglion." [OBOL:automatic] synonym: "future Meckel ganglion" EXACT [MP:0008314, OBOL:automatic] synonym: "future Meckel's ganglion" EXACT [FMA:6965, OBOL:automatic] synonym: "future nasal ganglion" EXACT [MP:0008314, OBOL:automatic] synonym: "future palatine ganglion" EXACT [MP:0008314, OBOL:automatic] synonym: "future pterygopalatine ganglia" EXACT [MP:0008314, OBOL:automatic] synonym: "future sphenopalatine ganglion" EXACT [MP:0008314, OBOL:automatic] synonym: "future sphenopalatine parasympathetic ganglion" EXACT [EHDAA2:0000673, EHDAA2:0001889, OBOL:automatic] xref: EHDAA2:0000673 is_a: UBERON:0001808 ! parasympathetic ganglion intersection_of: UBERON:0000045 ! ganglion intersection_of: RO:0002387 UBERON:0003962 ! has potential to develop into pterygopalatine ganglion relationship: BFO:0000050 UBERON:0001808 {source="EHDAA2"} ! part of parasympathetic ganglion relationship: RO:0002387 UBERON:0003962 ! has potential to develop into pterygopalatine ganglion [Term] id: UBERON:0010129 name: femur cartilage element def: "A femur endochondral element that is composed primarily of cartilage tissue." [OBOL:automatic] synonym: "femoral cartilage condensation" EXACT [EMAPA:17742] xref: EMAPA:17742 is_a: UBERON:0005254 ! upper leg mesenchyme is_a: UBERON:0005863 ! cartilaginous condensation is_a: UBERON:0010885 ! hindlimb cartilage element is_a: UBERON:0015052 ! femur endochondral element intersection_of: UBERON:0015052 ! femur endochondral element intersection_of: RO:0002473 UBERON:0002418 ! composed primarily of cartilage tissue relationship: BFO:0000050 UBERON:0005254 {source="EMAPA"} ! part of upper leg mesenchyme relationship: RO:0002202 UBERON:0006234 ! develops from femur pre-cartilage condensation relationship: RO:0002387 UBERON:0000981 ! has potential to develop into femur property_value: IAO:0000116 "TODO - request EHDAA2" xsd:string [Term] id: UBERON:0010130 name: embryonic autopod plate def: "The distal elements of the developing limb of vertebrates that will give rise to the autopod (e.g. manus, pes, paw)." [https://github.com/obophenotype/mammalian-phenotype-ontology/issues/1151, MP:0004576, UBERON:cjm] synonym: "autopod plate" EXACT [] synonym: "limb plate" EXACT [] is_a: BFO:0000002 is_a: UBERON:0006598 ! presumptive structure intersection_of: UBERON:0002050 ! embryonic structure intersection_of: RO:0002387 UBERON:0002470 ! has potential to develop into autopod region relationship: RO:0002202 UBERON:0004347 ! develops from limb bud relationship: RO:0002387 UBERON:0002470 ! has potential to develop into autopod region [Term] id: UBERON:0010131 name: conducting tissue of heart def: "Any portion of cardiac muscle tissue that is part of the conducting system of heart or the Purkinje fibers." [http://orcid.org/0000-0002-6601-2165] synonym: "specialized conducting tissue of heart" EXACT [FMA:83378] synonym: "specialized muscle tissue of heart" EXACT [FMA:83378] xref: EHDAA2:0004528 xref: FMA:83378 is_a: UBERON:0001133 ! cardiac muscle tissue property_value: skos:prefLabel "conducting tissue of heart" xsd:string [Term] id: UBERON:0010133 name: neuroendocrine gland def: "Any of the organized aggregations of cells that function as secretory or excretory organs and that release hormones in response to neural stimuli." [ISBN:0-683-40008-8, MP:0000631] subset: pheno_slim synonym: "neuroendocrine system gland" EXACT [] xref: MA:0000720 is_a: BFO:0000002 is_a: UBERON:0002368 ! endocrine gland intersection_of: UBERON:0002368 ! endocrine gland intersection_of: BFO:0000050 UBERON:8600018 ! part of neuroendocrine system relationship: BFO:0000050 UBERON:8600018 ! part of neuroendocrine system relationship: BFO:0000051 CL:0000165 ! has part neuroendocrine cell property_value: skos:prefLabel "neuroendocrine gland" xsd:string [Term] id: UBERON:0010134 name: secretory circumventricular organ def: "A circumventricular organ that is capable of secreting substances into the cerebrospinal fluid." [http://orcid.org/0000-0002-6601-2165] subset: pheno_slim xref: EMAPA:35759 xref: MA:0002943 xref: neuronames:2857 is_a: UBERON:0005408 {source="MA"} ! circumventricular organ is_a: UBERON:0010133 {source="MA"} ! neuroendocrine gland intersection_of: UBERON:0005408 ! circumventricular organ intersection_of: BFO:0000050 UBERON:0000949 ! part of endocrine system property_value: skos:prefLabel "secretory circumventricular organ" xsd:string [Term] id: UBERON:0010135 name: sensory circumventricular organ def: "A circumventricular organ that is capable of monitoring the levels of substances to the cerebrospinal fluid." [http://orcid.org/0000-0002-6601-2165] subset: pheno_slim synonym: "humerosensory circumventricular organ" RELATED [] synonym: "humerosensory system" RELATED OMO:0003004 [NeuroNames:2856] synonym: "humerosensory system organ" RELATED [] synonym: "sensitive circumventricular organs" RELATED OMO:0003004 [NeuroNames:2856] synonym: "sensitive organs" RELATED OMO:0003004 [NeuroNames:2856] synonym: "sensory circumventricular organs" RELATED [NeuroNames:2856] synonym: "sensory CVOs" RELATED OMO:0003004 [NeuroNames:2856] xref: EMAPA:37741 {source="MA:th"} xref: MA:0002944 xref: neuronames:2856 is_a: UBERON:0005408 ! circumventricular organ intersection_of: UBERON:0005408 ! circumventricular organ intersection_of: BFO:0000050 UBERON:0001032 ! part of sensory system relationship: BFO:0000050 UBERON:0001032 ! part of sensory system property_value: skos:prefLabel "sensory circumventricular organ" xsd:string [Term] id: UBERON:0010136 name: epithelial sheet def: "An epithelial sheet is a flat surface consisting of closely packed epithelial cells." [GO:0002011] is_a: UBERON:0000483 ! epithelium [Term] id: UBERON:0010141 name: primitive sex cord of indifferent gonad def: "A sex cord that is part of a indifferent gonad." [OBOL:automatic] synonym: "indifferent sex cord" EXACT [] synonym: "primitive sex cords" EXACT [EHDAA2:0004051] xref: EHDAA2:0004051 is_a: UBERON:0004909 ! epithelium of gonad is_a: UBERON:0005295 ! sex cord intersection_of: UBERON:0005295 {source="EHDAA2"} ! sex cord intersection_of: BFO:0000050 UBERON:0009117 {source="EHDAA2"} ! part of indifferent gonad relationship: BFO:0000050 UBERON:0009117 ! part of indifferent gonad relationship: RO:0002202 UBERON:0005891 {source="EHDAA2"} ! develops from coelomic epithelium [Term] id: UBERON:0010143 name: seminal vesicle fluid def: "A bodily secretion that is produced by a seminal vesicle." [http://orcid.org/0000-0002-6601-2165] synonym: "secretion of seminal vesicle" EXACT [FMA:62969] synonym: "seminal fluid" RELATED INCONSISTENT [] synonym: "seminal vesicle secretion" EXACT [FMA:62969] synonym: "vesicular fluid" BROAD [] xref: BTO:0002053 xref: FMA:62969 xref: MA:0002526 xref: NCIT:C33529 xref: NCIT:C52552 xref: UMLS:C0036614 {source="ncithesaurus:Seminal_Fluid"} xref: UMLS:C0227987 {source="ncithesaurus:Seminal_Vesicle_Secretion"} is_a: UBERON:0006530 {source="FMA"} ! seminal fluid intersection_of: UBERON:0000456 ! secretion of exocrine gland intersection_of: RO:0003001 UBERON:0000998 ! produced by seminal vesicle relationship: RO:0003001 UBERON:0000998 ! produced by seminal vesicle [Term] id: UBERON:0010147 name: male accessory sex gland def: "Any gland, other than the gonad, associated with the genital tract, such as the ampulla of the ductus deferens and the bulbourethral, prostate and vesicular glands of the male." [BTO:0004798] subset: human_reference_atlas subset: pheno_slim synonym: "male accessory gland" RELATED [BTO:0004798] synonym: "male accessory reproductive gland" RELATED [] xref: BTO:0004798 is_a: UBERON:0005399 {source="BTO"} ! male reproductive gland property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0010152 name: skin mucus def: "A mucous secretion that is produced by glands in the epidermis." [http://orcid.org/0000-0002-6601-2165] synonym: "epidermal mucus" RELATED [BTO:0005082] synonym: "skin mucous" RELATED [] is_a: UBERON:0000912 ! mucus intersection_of: UBERON:0000912 ! mucus intersection_of: RO:0003001 UBERON:0004790 ! produced by skin mucous gland relationship: RO:0003001 UBERON:0004790 ! produced by skin mucous gland property_value: skos:prefLabel "skin mucus" xsd:string [Term] id: UBERON:0010156 name: sphenofrontal suture def: "The Sphenofrontal suture is the cranial suture between the sphenoid bone and the frontal bone." [Wikipedia:Sphenofrontal_suture] synonym: "frontosphenoid suture" EXACT [FMA:52938] synonym: "spheno-frontal suture" RELATED [] synonym: "sphenofrontal" RELATED [Wikipedia:Sphenofrontal_suture] synonym: "sphenofrontal suture of skull" EXACT [FMA:52938] synonym: "sutura sphenofrontalis" RELATED OMO:0003011 [Wikipedia:Sphenofrontal_suture] xref: FMA:52938 xref: SCTID:136349005 xref: Wikipedia:Sphenofrontal_suture is_a: UBERON:0003685 ! cranial suture intersection_of: UBERON:0003685 ! cranial suture intersection_of: RO:0002176 UBERON:0000209 ! connects tetrapod frontal bone intersection_of: RO:0002176 UBERON:0001677 ! connects sphenoid bone relationship: RO:0002176 UBERON:0000209 ! connects tetrapod frontal bone relationship: RO:0002176 UBERON:0001677 ! connects sphenoid bone property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/2/2d/Gray164.png" xsd:anyURI property_value: skos:prefLabel "sphenofrontal suture" xsd:string [Term] id: UBERON:0010160 name: lumen of lymphatic vessel def: "An anatomical cavity that surrounded_by a lymphatic vessel." [OBOL:automatic] synonym: "lumen of lymphatic duct" EXACT [FMA:59681] synonym: "lymphatic vessel lumen" EXACT [FMA:59681] xref: FMA:59681 is_a: UBERON:0000464 ! anatomical space intersection_of: UBERON:0000464 ! anatomical space intersection_of: RO:0002572 UBERON:0001473 ! luminal space of lymphatic vessel relationship: RO:0002572 UBERON:0001473 ! luminal space of lymphatic vessel [Term] id: UBERON:0010161 name: lumen of blood vessel def: "An anatomical cavity that surrounded_by a blood vessel." [OBOL:automatic] synonym: "blood vessel lumen" EXACT [] xref: FMA:312610 xref: SCTID:91747007 is_a: UBERON:0000464 ! anatomical space intersection_of: UBERON:0000464 ! anatomical space intersection_of: RO:0002572 UBERON:0001981 ! luminal space of blood vessel relationship: RO:0002572 UBERON:0001981 ! luminal space of blood vessel property_value: skos:prefLabel "lumen of blood vessel" xsd:string [Term] id: UBERON:0010162 name: post-anal tail tip def: "The distal end of the tail." [http://orcid.org/0000-0002-6601-2165] subset: pheno_slim synonym: "end of tail" RELATED [MA:0002848] synonym: "tail tip" EXACT [MA:0002848] xref: EMAPA:37760 {source="MA:th"} xref: MA:0002848 xref: XAO:0004057 is_a: UBERON:0011676 ! subdivision of organism along main body axis intersection_of: UBERON:0011676 ! subdivision of organism along main body axis intersection_of: BSPO:0001108 UBERON:0007812 ! post-anal tail relationship: BSPO:0001108 UBERON:0007812 ! post-anal tail property_value: skos:prefLabel "post-anal tail tip" xsd:string [Term] id: UBERON:0010164 name: collection of hairs def: "An anatomical cluster that composed_primarily_of a strand of hair." [OBOL:automatic] synonym: "hairs" EXACT [FMA:70752] synonym: "hairs set" EXACT [FMA:70752] synonym: "pili" EXACT OMO:0003011 [FMA:TA] synonym: "set of hairs" EXACT [FMA:70752] xref: FMA:70752 is_a: BFO:0000002 is_a: BFO:0000004 is_a: UBERON:0034925 ! anatomical collection intersection_of: UBERON:0034925 ! anatomical collection intersection_of: RO:0002351 UBERON:0001037 ! has member strand of hair relationship: RO:0000086 PATO:0010001 ! has quality disconnected relationship: RO:0002351 UBERON:0001037 ! has member strand of hair [Term] id: UBERON:0010165 name: collection of hair on face def: "A collection of hairs that is part of a face." [OBOL:automatic] subset: phenotype_rcn synonym: "facial hair" RELATED [] synonym: "facial hairs set" EXACT [FMA:70741] synonym: "set of facial hairs" EXACT [FMA:70741] xref: FMA:70741 is_a: UBERON:0014382 ! collection of hairs on head or neck intersection_of: UBERON:0010164 ! collection of hairs intersection_of: BFO:0000050 UBERON:0001456 ! part of face relationship: BFO:0000050 UBERON:0001456 ! part of face relationship: RO:0002351 UBERON:0010171 ! has member strand of hair of face [Term] id: UBERON:0010171 name: strand of hair of face def: "A strand of hair that is part of a face." [OBOL:automatic] subset: pheno_slim synonym: "face hair" EXACT [FMA:54360] synonym: "face hair strand" EXACT [] synonym: "facial hair" RELATED [FMA:54360] synonym: "hair of face" EXACT [FMA:54360] xref: FMA:54360 xref: SCTID:368910000 is_a: UBERON:0016446 ! hair of head intersection_of: UBERON:0001037 ! strand of hair intersection_of: BFO:0000050 UBERON:0001456 ! part of face relationship: BFO:0000050 UBERON:0001456 ! part of face [Term] id: UBERON:0010183 name: liver trabecula def: "A trabecula that is part of a liver." [GO:0060344, OBOL:automatic] synonym: "hepatic trabecula" RELATED [] synonym: "liver trabeculae" EXACT OMO:0003004 [] is_a: UBERON:0000440 ! trabecula intersection_of: UBERON:0000440 ! trabecula intersection_of: BFO:0000050 UBERON:0002107 ! part of liver relationship: BFO:0000050 UBERON:0002107 ! part of liver property_value: skos:prefLabel "liver trabecula" xsd:string [Term] id: UBERON:0010186 name: male urethral gland def: "Any of the numerous small mucous-secreting glands located in the wall of the penile urethra." [MGI:anna, MP:0011794] subset: pheno_slim synonym: "gland of Littre" EXACT [] synonym: "gland of male urethra" EXACT [] synonym: "glandulae urethrales urethrae masculinae" RELATED OMO:0003011 [Wikipedia:Urethral_gland] synonym: "Littre's gland" EXACT [FMA:21443] synonym: "male urethra gland" EXACT [] synonym: "urethral gland (male)" EXACT [FMA:21443] xref: EMAPA:29645 xref: FMA:21443 xref: NCIT:C49311 xref: SCTID:303562001 xref: UMLS:C1314737 {source="ncithesaurus:Urethral_Gland"} xref: Wikipedia:Urethral_gland is_a: UBERON:0001338 ! urethral gland intersection_of: UBERON:0001338 ! urethral gland intersection_of: BFO:0000050 UBERON:0001333 ! part of male urethra relationship: BFO:0000050 UBERON:0001333 ! part of male urethra [Term] id: UBERON:0010187 name: female urethral gland def: "An urethral gland that is part of a female urethra." [OBOL:automatic] synonym: "female urethra gland" EXACT [] synonym: "gland of female urethra" EXACT [] synonym: "urethral gland (female)" EXACT [FMA:21444] xref: EMAPA:29653 xref: FMA:21444 xref: SCTID:279476001 is_a: UBERON:0001338 ! urethral gland intersection_of: UBERON:0001338 ! urethral gland intersection_of: BFO:0000050 UBERON:0001334 ! part of female urethra relationship: BFO:0000050 UBERON:0001334 ! part of female urethra [Term] id: UBERON:0010188 name: protuberance def: "A roughly circular bulge in a surface." [EHDAA2:0003250] xref: AEO:0000205 xref: EHDAA2:0003250 xref: FMA:82506 is_a: UBERON:0034944 {source="FMA"} ! zone of organ property_value: IAO:0000116 "requires review" xsd:string property_value: skos:prefLabel "protuberance" xsd:string [Term] id: UBERON:0010189 name: right atrium venous valve synonym: "right venous valve" RELATED [EHDAA2:0001762] xref: EHDAA2:0001762 xref: EMAPA:17010 xref: EMAPA:17328 xref: MA:0001872 is_a: UBERON:0005208 ! right atrium valve is_a: UBERON:0006675 ! venous valve intersection_of: UBERON:0006675 ! venous valve intersection_of: BFO:0000050 UBERON:0002078 ! part of right cardiac atrium [Term] id: UBERON:0010191 name: aortic system xref: EHDAA2:0004512 is_a: UBERON:0011216 ! organ system subdivision relationship: BFO:0000050 UBERON:0004571 {source="Wikipedia"} ! part of systemic arterial system property_value: skos:prefLabel "aortic system" xsd:string [Term] id: UBERON:0010192 name: genital artery def: "One of the laterally paired arteries that supply the gonads." [ISBN:0073040584, Wikipedia:Gonadal_artery] synonym: "gonadal artery" EXACT [] xref: Wikipedia:Gonadal_artery is_a: UBERON:0012254 ! abdominal aorta artery intersection_of: UBERON:0004573 ! systemic artery intersection_of: RO:0020101 UBERON:0000991 ! vessel supplies blood to gonad relationship: RO:0020101 UBERON:0000991 ! vessel supplies blood to gonad property_value: skos:prefLabel "genital artery" xsd:string [Term] id: UBERON:0010194 name: hepatic portal system def: "A portal system that begins in capillaries in the wall of the digestive tract and and runs as the hepatic portal vein to the liver." [ISBN:0073040584] synonym: "hepatic-portal system" EXACT [AAO:0010225] synonym: "portal system of liver" EXACT [] xref: AAO:0010225 is_a: UBERON:0005806 ! portal system relationship: RO:0002176 UBERON:0001555 ! connects digestive tract relationship: RO:0002176 UBERON:0002107 ! connects liver property_value: skos:prefLabel "hepatic portal system" xsd:string [Term] id: UBERON:0010199 name: bona-fide anatomical boundary def: "An anatomical boundary that corresponds to some physical discontinuity." [CARO:0001004] comment: One might argue that all boundaries are actually fiat in the sense that there must be some fiat element at a fine enough scale of granularity. This ontology choses to ignore this issue as below the level of granularity relevant to anatomy. (DOS121102) subset: upper_level xref: CARO:0001004 is_a: UBERON:0000466 {source="CARO"} ! immaterial anatomical entity property_value: skos:prefLabel "bona-fide anatomical boundary" xsd:string [Term] id: UBERON:0010202 name: lateral line def: "The lateral line consists of small sensory patches (neuromasts) located superficially on the skin or just under the skin in fluid-filled canals on the head and body of all fishes and most amphibians. The lateral line develops from cranial ectodermal placodes situated behind the ear and between the eye and ear." [Wikipedia:Lateral_line, ZFA:0001469] synonym: "lateral lines" EXACT OMO:0003004 [ZFA:0001469] xref: AAO:0011128 xref: TAO:0001469 xref: Wikipedia:Lateral_line xref: XAO:0004002 xref: ZFA:0001469 is_a: UBERON:0000479 {source="ZFA"} ! tissue is_a: UBERON:0004121 ! ectoderm-derived structure relationship: BFO:0000050 UBERON:0002540 {source="ZFA"} ! part of lateral line system relationship: RO:0002202 UBERON:0009128 ! develops from lateral line placode [Term] id: UBERON:0010204 name: tail vasculature def: "A vasculature that is part of a post-anal tail." [OBOL:automatic] synonym: "post-vent vasculature" EXACT [ZFA:0005037] synonym: "tail vasculature" RELATED [ZFA:0005037] xref: TAO:0005037 xref: XAO:0004151 xref: ZFA:0005037 is_a: UBERON:0002049 ! vasculature intersection_of: UBERON:0002049 ! vasculature intersection_of: BFO:0000050 UBERON:0007812 ! part of post-anal tail relationship: BFO:0000050 UBERON:0007812 ! part of post-anal tail property_value: skos:prefLabel "tail vasculature" xsd:string [Term] id: UBERON:0010210 name: blood clot def: "A semisolid gelatinous mass of coagulated blood that consists of red blood cells, white blood cells, and platelets entrapped in a fibrin network." [BTO:0000102, Wikipedia:Thrombus] synonym: "clot" NARROW [] synonym: "coagulated blood" EXACT [] synonym: "fibrin clot" EXACT [] synonym: "hemostatic plug" EXACT [Wikipedia:Thrombus] synonym: "thrombus" EXACT [BTO:0000102] xref: BTO:0000102 xref: galen:BloodClot xref: Wikipedia:Thrombus is_a: BFO:0000002 is_a: UBERON:0000463 ! organism substance intersection_of: UBERON:0000463 ! organism substance intersection_of: RO:0002353 GO:0007596 ! output of blood coagulation relationship: BFO:0000051 CL:0000232 ! has part erythrocyte relationship: BFO:0000051 CL:0000233 ! has part platelet relationship: BFO:0000051 CL:0000738 ! has part leukocyte relationship: BFO:0000051 GO:0005577 ! has part fibrinogen complex relationship: RO:0002202 UBERON:0000178 {source="BTO"} ! develops from blood relationship: RO:0002353 GO:0007596 ! output of blood coagulation [Term] id: UBERON:0010212 name: laryngeal apparatus def: "Apparatus located between the lungs and the buccal cavity. This apparatus is composed of a pair of arytenoid cartilages that are supported by the cricoid ring." [AAO:0000267] synonym: "laryngeal cartilage system" EXACT [EHDAA2:0000904] xref: AAO:0000267 xref: EHDAA2:0000904 is_a: BFO:0000002 is_a: UBERON:0034921 ! multi organ part structure relationship: BFO:0000050 UBERON:0001737 {source="EHDAA2"} ! part of larynx relationship: BFO:0000050 UBERON:0008895 ! part of splanchnocranium relationship: RO:0002473 UBERON:0001739 ! composed primarily of laryngeal cartilage property_value: IAO:0000116 "check this. See also https://github.com/obophenotype/uberon/wiki/The-axial-skeleton" xsd:string property_value: skos:prefLabel "laryngeal apparatus" xsd:string [Term] id: UBERON:0010213 name: laryngeal pre-cartilage condensation is_a: UBERON:0005866 ! pre-cartilage condensation relationship: BFO:0000050 UBERON:0010212 {source="EHDAA2-abstracted"} ! part of laryngeal apparatus relationship: RO:0002202 UBERON:0010221 {source="EHDAA2-abstracted"} ! develops from laryngeal associated mesenchyme property_value: skos:prefLabel "laryngeal pre-cartilage condensation" xsd:string [Term] id: UBERON:0010221 name: laryngeal associated mesenchyme comment: Many sources say: thyroid cartilage from arch 4 other laryngeal cartilage (cricoid/arytenoid) from 6? xref: EHDAA2:0004085 is_a: UBERON:0007524 {source="EHDAA2"} ! dense mesenchyme tissue relationship: BFO:0000050 UBERON:0001737 {source="EHDAA2"} ! part of larynx relationship: BFO:0000050 UBERON:0008895 ! part of splanchnocranium relationship: RO:0002202 UBERON:0002539 {source="Wikipedia"} ! develops from pharyngeal arch relationship: RO:0002254 UBERON:0003115 {source="Wikipedia"} ! has developmental contribution from pharyngeal arch 4 relationship: RO:0002254 UBERON:0003117 {source="Wikipedia"} ! has developmental contribution from pharyngeal arch 6 property_value: skos:prefLabel "laryngeal associated mesenchyme" xsd:string [Term] id: UBERON:0010225 name: thalamic complex def: "A nuclear complex which in mammals consists of four parts, the hypothalamus, epithalamus, ventral thalamus, and dorsal thalamus[WP,modified]." [Wikipedia:Thalamus#Thalamic_nuclei] xref: EHDAA2:0004469 xref: FMA:258745 is_a: UBERON:0007245 ! nuclear complex of neuraxis is_a: UBERON:0019269 ! gray matter of diencephalon property_value: skos:prefLabel "thalamic complex" xsd:string [Term] id: UBERON:0010227 name: future cardiac atrium def: "Multi-tissue structure that is part of the heart tube and will become the cardiac atrium." [ZFA:0001718] synonym: "presumptive atrium heart tube" EXACT [ZFA:0001718] synonym: "primordial atrium" EXACT [FMA:71005] synonym: "primordial cardiac atrium" EXACT [FMA:71005] xref: FMA:71005 xref: TAO:0002228 xref: ZFA:0001718 is_a: UBERON:0006598 ! presumptive structure relationship: BFO:0000050 UBERON:0004141 {source="ZFA"} ! part of heart tube relationship: RO:0002387 UBERON:0002081 ! has potential to develop into cardiac atrium property_value: skos:prefLabel "future cardiac atrium" xsd:string [Term] id: UBERON:0010230 name: eyeball of camera-type eye def: "The core globe-shaped component of the camera-type eye." [UBERON:cjm] subset: pheno_slim synonym: "bulbus oculi" EXACT [] synonym: "eye" RELATED INCONSISTENT [] synonym: "eye globe" EXACT [VHOG:0001616] synonym: "eyeball" EXACT [FMA:12513] synonym: "globe" RELATED [HP:0100886, MIAA:0000283] xref: FMA:12513 xref: MIAA:0000283 xref: SCTID:244486005 xref: VHOG:0001616 xref: Wikipedia:Globe_(human_eye) is_a: UBERON:0000020 ! sense organ relationship: BFO:0000050 UBERON:0000019 {source="FMA"} ! part of camera-type eye relationship: RO:0002433 UBERON:0000019 ! contributes to morphology of camera-type eye property_value: skos:prefLabel "eyeball of camera-type eye" xsd:string [Term] id: UBERON:0010233 name: stroma of thyroid gland def: "The connective tissue that supports the lobules and follicles of the thyroid gland." [http://www.drugs.com/dict/stroma-of-thyroid-gland.html] synonym: "thyroid gland stroma" EXACT [FMA:86304] synonym: "thyroid stroma" EXACT [] xref: FMA:86304 xref: SCTID:157862000 is_a: UBERON:0003891 ! stroma is_a: UBERON:0010313 ! neural crest-derived structure intersection_of: UBERON:0003891 ! stroma intersection_of: BFO:0000050 UBERON:0002046 ! part of thyroid gland relationship: BFO:0000050 UBERON:0002046 ! part of thyroid gland [Term] id: UBERON:0010243 name: merocrine gland def: "An exocrine gland whose secretions are excreted via exocytosis from secretory cells into an epithelial-walled duct or ducts and thence onto a bodily surface or into the lumen; the gland releases its product and no part of the gland is lost or damaged." [MGI:anna, MP:0013544, Wikipedia:Merocrine] subset: pheno_slim xref: BTO:0002324 xref: MA:0003041 xref: Wikipedia:Merocrine is_a: UBERON:0002365 ! exocrine gland intersection_of: UBERON:0002365 ! exocrine gland intersection_of: RO:0002215 GO:0006887 ! capable of exocytosis relationship: RO:0002215 GO:0006887 ! capable of exocytosis [Term] id: UBERON:0010252 name: 1st arch mandibular mesenchyme from neural crest def: "Mesenchyme that develops_from a neural crest and is part of a 1st arch mandibular mesenchyme." [OBOL:automatic] xref: EHDAA2:0000037 is_a: UBERON:0009584 ! 1st arch mandibular mesenchyme is_a: UBERON:0010259 {source="inferred"} ! 1st arch mesenchyme from neural crest intersection_of: UBERON:0003104 ! mesenchyme intersection_of: BFO:0000050 UBERON:0009584 ! part of 1st arch mandibular mesenchyme intersection_of: RO:0002202 UBERON:0002342 ! develops from neural crest relationship: BFO:0000050 UBERON:0009584 {source="EHDAA2"} ! part of 1st arch mandibular mesenchyme relationship: BFO:0000050 UBERON:0010258 {source="EHDAA2"} ! part of mesenchyme from rhombencephalic neural crest relationship: RO:0002202 UBERON:0007098 ! develops from mandibular neural crest property_value: skos:prefLabel "1st arch mandibular mesenchyme from neural crest" xsd:string [Term] id: UBERON:0010253 name: 1st arch maxillary mesenchyme from neural crest def: "Mesenchyme that develops_from a neural crest and is part of a 1st arch maxillary mesenchyme." [OBOL:automatic] xref: EHDAA2:0000044 is_a: UBERON:0010045 ! 1st arch maxillary mesenchyme is_a: UBERON:0010259 ! 1st arch mesenchyme from neural crest intersection_of: UBERON:0003104 ! mesenchyme intersection_of: BFO:0000050 UBERON:0010045 ! part of 1st arch maxillary mesenchyme intersection_of: RO:0002202 UBERON:0002342 ! develops from neural crest relationship: BFO:0000050 UBERON:0010045 {source="EHDAA2"} ! part of 1st arch maxillary mesenchyme relationship: BFO:0000050 UBERON:0010258 {source="EHDAA2"} ! part of mesenchyme from rhombencephalic neural crest property_value: skos:prefLabel "1st arch maxillary mesenchyme from neural crest" xsd:string [Term] id: UBERON:0010254 name: 2nd arch mesenchyme from neural crest def: "Mesenchyme that develops_from a neural crest and is part of a 2nd arch mesenchyme." [OBOL:automatic] synonym: "branchial arch 2 mesenchyme from neural crest" RELATED [] synonym: "neural crest derived arch 2 mesenchyme" EXACT [] synonym: "pharyngeal arch 2 mesenchyme from neural crest" EXACT [] xref: EHDAA2:0000068 xref: EMAPA:16281 is_a: UBERON:0005689 ! 2nd arch mesenchyme is_a: UBERON:0007213 ! mesenchyme derived from head neural crest is_a: UBERON:0010359 ! pharyngeal arch mesenchyme from neural crest intersection_of: UBERON:0003104 ! mesenchyme intersection_of: BFO:0000050 UBERON:0005689 ! part of 2nd arch mesenchyme intersection_of: RO:0002202 UBERON:0002342 ! develops from neural crest relationship: BFO:0000050 UBERON:0005689 {source="EHDAA2"} ! part of 2nd arch mesenchyme relationship: BFO:0000050 UBERON:0010258 {source="EHDAA2"} ! part of mesenchyme from rhombencephalic neural crest relationship: RO:0002202 UBERON:0007099 ! develops from hyoid neural crest property_value: skos:prefLabel "2nd arch mesenchyme from neural crest" xsd:string [Term] id: UBERON:0010255 name: 3rd arch mesenchyme from neural crest def: "Mesenchyme that develops_from a neural crest and is part of a 3rd arch mesenchyme." [OBOL:automatic] synonym: "3rd pharyngeal arch mesenchyme derived from neural crest" EXACT [VHOG:0000571] synonym: "branchial arch 3 mesenchyme from neural crest" RELATED [] synonym: "mesenchyme derived from neural crest of mesenchyme of 3rd arch" EXACT [EMAPA:16404] synonym: "neural crest derived arch 3 mesenchyme" EXACT [] synonym: "pharyngeal arch 3 mesenchyme from neural crest" EXACT [] xref: EHDAA2:0000083 xref: EMAPA:16404 xref: VHOG:0000571 is_a: UBERON:0005690 ! 3rd arch mesenchyme is_a: UBERON:0010258 ! mesenchyme from rhombencephalic neural crest is_a: UBERON:0010359 ! pharyngeal arch mesenchyme from neural crest intersection_of: UBERON:0003104 ! mesenchyme intersection_of: BFO:0000050 UBERON:0005690 ! part of 3rd arch mesenchyme intersection_of: RO:0002202 UBERON:0002342 ! develops from neural crest relationship: BFO:0000050 UBERON:0005690 {source="EHDAA2"} ! part of 3rd arch mesenchyme property_value: skos:prefLabel "3rd arch mesenchyme from neural crest" xsd:string [Term] id: UBERON:0010256 name: 4th arch mesenchyme from neural crest def: "Mesenchyme that develops_from a neural crest and is part of a 4th arch mesenchyme." [OBOL:automatic] synonym: "4th pharyngeal arch mesenchyme derived from neural crest" EXACT [VHOG:0000580] synonym: "branchial arch 4 mesenchyme from neural crest" RELATED [] synonym: "mesenchyme derived from neural crest of mesenchyme of 4th arch" EXACT [EMAPA:16772] synonym: "neural crest derived arch 4 mesenchyme" EXACT [] synonym: "pharyngeal arch 4 mesenchyme from neural crest" EXACT [] xref: EHDAA2:0000098 xref: EMAPA:16772 xref: VHOG:0000580 is_a: UBERON:0005691 ! 4th arch mesenchyme is_a: UBERON:0010258 ! mesenchyme from rhombencephalic neural crest is_a: UBERON:0010359 ! pharyngeal arch mesenchyme from neural crest intersection_of: UBERON:0003104 ! mesenchyme intersection_of: BFO:0000050 UBERON:0005691 ! part of 4th arch mesenchyme intersection_of: RO:0002202 UBERON:0002342 ! develops from neural crest relationship: BFO:0000050 UBERON:0005691 {source="EHDAA2"} ! part of 4th arch mesenchyme relationship: BFO:0000050 UBERON:0010258 {source="EHDAA2"} ! part of mesenchyme from rhombencephalic neural crest property_value: skos:prefLabel "4th arch mesenchyme from neural crest" xsd:string [Term] id: UBERON:0010257 name: 6th arch mesenchyme from neural crest def: "Mesenchyme that develops_from a neural crest and is part of a 6th arch mesenchyme." [OBOL:automatic] synonym: "branchial arch 6 mesenchyme from neural crest" RELATED [] synonym: "neural crest derived arch 6 mesenchyme" EXACT [] synonym: "pharyngeal arch 6 mesenchyme from neural crest" EXACT [] xref: EHDAA2:0004077 is_a: UBERON:0010031 ! 6th arch mesenchyme is_a: UBERON:0010258 ! mesenchyme from rhombencephalic neural crest is_a: UBERON:0010359 ! pharyngeal arch mesenchyme from neural crest intersection_of: UBERON:0003104 ! mesenchyme intersection_of: BFO:0000050 UBERON:0010031 ! part of 6th arch mesenchyme intersection_of: RO:0002202 UBERON:0002342 ! develops from neural crest relationship: BFO:0000050 UBERON:0010031 {source="EHDAA2"} ! part of 6th arch mesenchyme relationship: BFO:0000050 UBERON:0010258 {source="EHDAA2"} ! part of mesenchyme from rhombencephalic neural crest property_value: skos:prefLabel "6th arch mesenchyme from neural crest" xsd:string [Term] id: UBERON:0010258 name: mesenchyme from rhombencephalic neural crest def: "Mesenchyme that develops_from a rhombencephalon neural crest." [OBOL:automatic] xref: EHDAA2:0004423 is_a: UBERON:0007213 ! mesenchyme derived from head neural crest is_a: UBERON:0014387 ! mesenchyme derived from neural crest intersection_of: UBERON:0003104 ! mesenchyme intersection_of: RO:0002202 UBERON:0003852 ! develops from rhombencephalon neural crest relationship: BFO:0000050 UBERON:0007213 {source="EHDAA2"} ! part of mesenchyme derived from head neural crest relationship: RO:0002202 UBERON:0003852 ! develops from rhombencephalon neural crest property_value: skos:prefLabel "mesenchyme from rhombencephalic neural crest" xsd:string [Term] id: UBERON:0010259 name: 1st arch mesenchyme from neural crest def: "Mesenchyme that develops_from a neural crest and is part of a 1st arch mesenchyme." [OBOL:automatic] synonym: "branchial arch 1 mesenchyme from neural crest" RELATED [] synonym: "mesenchyme derived from neural crest of mesenchyme of 1st arch" EXACT [EMAPA:16129] synonym: "neural crest derived arch 1 mesenchyme" EXACT [] synonym: "pharyngeal arch 1 mesenchyme from neural crest" EXACT [] xref: EMAPA:16129 is_a: UBERON:0010042 ! 1st arch mesenchyme is_a: UBERON:0010258 ! mesenchyme from rhombencephalic neural crest is_a: UBERON:0010359 ! pharyngeal arch mesenchyme from neural crest intersection_of: UBERON:0003104 ! mesenchyme intersection_of: BFO:0000050 UBERON:0010042 ! part of 1st arch mesenchyme intersection_of: RO:0002202 UBERON:0002342 ! develops from neural crest relationship: BFO:0000050 UBERON:0010042 ! part of 1st arch mesenchyme property_value: skos:prefLabel "1st arch mesenchyme from neural crest" xsd:string [Term] id: UBERON:0010260 name: umbilical blood vessel def: "One of the three blood vessels, usually one large umbilical vein and two small umbilical arteries, buried within Wharton's jelly, that transport blood to and from the placenta, where exchange between the mother and fetus takes place; the umbilical vein carries oxygenated, nutrient-rich blood from the placenta to the fetus, and the umbilical arteries carry deoxygenated, nutrient-depleted blood from the fetus to the placenta." [MP:0003230] subset: pheno_slim synonym: "allantoic vessel" EXACT [Hymans:Hymans] synonym: "umbilical cord blood vessel" EXACT [] synonym: "umbilical cord blood vessels" RELATED OMO:0003004 [] synonym: "umbilical vasculature" RELATED [] synonym: "umbilical vessel" EXACT [] xref: EMAPA:36493 xref: SCTID:408728001 is_a: UBERON:0001981 ! blood vessel intersection_of: UBERON:0001981 ! blood vessel intersection_of: RO:0002131 UBERON:0002331 ! overlaps umbilical cord relationship: RO:0001025 UBERON:0003422 ! located in mesenchyme of umbilical cord relationship: RO:0002131 UBERON:0002331 ! overlaps umbilical cord [Term] id: UBERON:0010272 name: hyoid apparatus def: "A group of bones comprised of hyoid body and two pairs of cornua (i.e. greater cornua and lesser cornua), and lies just below the tongue, above the thyroid cartilage." [http://www.biology-online.org/dictionary/Hyoid_apparatus] synonym: "apparatus hyobranchialis" RELATED OMO:0003011 [] synonym: "apparatus hyoideus" RELATED [http://www.biology-online.org/dictionary/Hyoid_apparatus] synonym: "hyobranchial apparatus" RELATED [AAO:0000225] synonym: "hyolingual system" RELATED [AAO:0000225] xref: AAO:0000225 xref: AAO:0000682 xref: EMAPA:37600 {source="MA:th"} xref: http://palaeos.com/vertebrates/bones/gill_arches/images/ReptileHyoids.gif xref: MA:0003037 xref: SCTID:410035009 is_a: UBERON:0000075 ! subdivision of skeletal system relationship: BFO:0000050 UBERON:0005884 {source="AAO"} ! part of hyoid arch skeleton property_value: skos:prefLabel "hyoid apparatus" xsd:string [Term] id: UBERON:0010273 name: zone of hyoid bone def: "A zone of bone organ that is part of a hyoid bone." [OBOL:automatic] synonym: "hyoid bone zone" EXACT [FMA:59494] xref: FMA:59494 xref: SCTID:119534005 is_a: UBERON:0005913 ! zone of bone organ intersection_of: UBERON:0005913 ! zone of bone organ intersection_of: BFO:0000050 UBERON:0001685 ! part of hyoid bone relationship: BFO:0000050 UBERON:0001685 ! part of hyoid bone property_value: skos:prefLabel "zone of hyoid bone" xsd:string [Term] id: UBERON:0010276 name: space in vertebral column def: "Any anatomical space that is part of a vertebral column." [OBOL:automatic] synonym: "vertebral column opening" EXACT [AAO:0000700] synonym: "vertebral conduit" EXACT [] xref: AAO:0000700 is_a: UBERON:0000464 ! anatomical space intersection_of: UBERON:0000464 ! anatomical space intersection_of: BFO:0000050 UBERON:0001130 ! part of vertebral column relationship: BFO:0000050 UBERON:0001130 ! part of vertebral column property_value: skos:prefLabel "space in vertebral column" xsd:string [Term] id: UBERON:0010284 name: lacrimal punctum def: "A minute orifice on the summit of the papillae lacrimales, which is the commencement point of the lacrimal canaliculi." [Wikipedia:Lacrimal_punctum] subset: pheno_slim synonym: "lacrimal point" RELATED [Wikipedia:Lacrimal_punctum] synonym: "lacrimal puncta" RELATED OMO:0003004 [Wikipedia:Lacrimal_punctum] synonym: "puncta lacrimalia" RELATED OMO:0003011 [Wikipedia:Lacrimal_punctum] xref: FMA:59365 xref: SCTID:263344003 xref: Wikipedia:Lacrimal_punctum is_a: UBERON:0000161 {source="FMA"} ! orifice relationship: BFO:0000050 UBERON:0001850 ! part of lacrimal drainage system property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/5/53/Gray895.png" xsd:anyURI [Term] id: UBERON:0010285 name: midbrain basal plate def: "Portion of tissue that is dorsolateral to the floor plate and part of the midbrain." [ZFA:0000761] subset: efo_slim synonym: "basal plate midbrain" EXACT [TAO:0000761] synonym: "basal plate midbrain region" EXACT [ZFA:0000761] xref: DHBA:12322 xref: EFO:0003567 xref: EHDAA2:0004375 xref: TAO:0000761 xref: ZFA:0000761 is_a: UBERON:0002020 {source="EHDAA2"} ! gray matter relationship: BFO:0000050 UBERON:0009581 {source="EHDAA2"} ! part of midbrain mantle layer relationship: BFO:0000050 UBERON:0010286 {source="ZFA"} ! part of midbrain neural tube property_value: skos:prefLabel "midbrain basal plate" xsd:string [Term] id: UBERON:0010286 name: midbrain neural tube def: "Portion of neural tube that gives rise to the midbrain." [ZFA:0007039] xref: TAO:0007039 xref: ZFA:0007039 is_a: UBERON:0005291 ! embryonic tissue relationship: BFO:0000050 UBERON:0003080 {source="ZFA"} ! part of anterior neural tube property_value: IAO:0000116 "we follow ZFA in temporally dividing midbrain NT from presumptive midbrain, but in future this may be collapsed" xsd:string property_value: skos:prefLabel "midbrain neural tube" xsd:string [Term] id: UBERON:0010291 name: layer of sclera xref: Wikipedia:Sclera#Histology is_a: UBERON:0004923 ! organ component layer relationship: BFO:0000050 UBERON:0001773 {source="cjm"} ! part of sclera property_value: skos:prefLabel "layer of sclera" xsd:string [Term] id: UBERON:0010294 name: scleral endothelium def: "An endothelium that is part of a sclera." [OBOL:automatic] is_a: UBERON:0001986 ! endothelium is_a: UBERON:0010291 {source="Wikipedia"} ! layer of sclera is_a: UBERON:0015808 ! eye epithelium intersection_of: UBERON:0001986 ! endothelium intersection_of: BFO:0000050 UBERON:0001773 ! part of sclera property_value: skos:prefLabel "scleral endothelium" xsd:string [Term] id: UBERON:0010295 name: substantia propria of sclera def: "A stroma that is part of a sclera." [OBOL:automatic] synonym: "scleral stroma" EXACT [FMA:58365] synonym: "stroma of sclera" EXACT [FMA:58365] synonym: "subsantia propria" BROAD [] synonym: "subsantia propria sclerae" EXACT [FMA:58365] synonym: "substantia propria sclerae" EXACT OMO:0003011 [FMA:58365, FMA:TA] xref: FMA:58365 xref: NCIT:C33652 xref: SCTID:368851004 xref: UMLS:C1704397 {source="ncithesaurus:Substantia_Propria"} is_a: UBERON:0003891 ! stroma is_a: UBERON:0010291 {source="Wikipedia"} ! layer of sclera intersection_of: UBERON:0003891 ! stroma intersection_of: BFO:0000050 UBERON:0001773 ! part of sclera [Term] id: UBERON:0010299 name: scleral mesenchyme def: "Mesenchyme surrounding the developing optic cup which develops into the sclera." [https://orcid.org/0000-0002-6601-2165, PMID:16496288] is_a: UBERON:0003104 ! mesenchyme intersection_of: UBERON:0003104 ! mesenchyme intersection_of: RO:0002387 UBERON:0001773 ! has potential to develop into sclera relationship: RO:0002221 UBERON:0003072 ! surrounds optic cup relationship: RO:0002387 UBERON:0001773 ! has potential to develop into sclera property_value: skos:prefLabel "scleral mesenchyme" xsd:string [Term] id: UBERON:0010302 name: amnioserosa def: "A single extraembryonic epithelium, which closes the germband dorsally." [DOI:10.1073/pnas.0709145105] subset: efo_slim synonym: "amnion-serosa" RELATED [BTO:0004800] xref: BTO:0004800 xref: EFO:0000250 xref: FBbt:00000095 {sssom:mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"} is_a: UBERON:0010303 {source="DOI:10.1073/pnas.0709145105"} ! extraembryonic epithelium relationship: RO:0002162 NCBITaxon:6656 ! in taxon Arthropoda property_value: IAO:0000116 "May be obsoleted once added to insect ontology. Coordinate with cell type in CL" xsd:string [Term] id: UBERON:0010303 name: extraembryonic epithelium def: "An epithelium that is part of a extraembryonic structure." [OBOL:automatic] synonym: "extra-embryonic epithelium" EXACT [] is_a: UBERON:0000483 ! epithelium is_a: UBERON:0005292 ! extraembryonic tissue intersection_of: UBERON:0000483 ! epithelium intersection_of: BFO:0000050 UBERON:0000478 ! part of extraembryonic structure relationship: BFO:0000050 UBERON:0000478 ! part of extraembryonic structure property_value: skos:prefLabel "extraembryonic epithelium" xsd:string [Term] id: UBERON:0010304 name: non-keratinized stratified squamous epithelium def: "Stratified squamous epithelium is a stratified squamous epithelium, the cells of which synthesizes but does not accumulate keratin. Examples: epithelium of vagina, epithelium of wall of esophagus." [FMA:45569, Wikipedia:Stratified_squamous_epithelium#Nonkeratinized] synonym: "epithelium stratificatum squamosum noncornificatum" EXACT [FMA:45569] synonym: "nonkeratinizing stratified squamous epithelium" EXACT [FMA:45569] synonym: "stratified squamous non-keratinized epithelium" EXACT [http://orcid.org/0000-0002-6601-2165] synonym: "stratified squamous nonkeratinizing epithelium" EXACT [http://orcid.org/0000-0002-6601-2165] xref: FMA:45569 xref: Wikipedia:Stratified_squamous_epithelium#Nonkeratinized is_a: UBERON:0006915 {source="FMA"} ! stratified squamous epithelium disjoint_from: UBERON:0012329 ! keratinized stratified squamous epithelium [Term] id: UBERON:0010305 name: subdivision of conjunctiva def: "One of the three major regions of the conjunctiva." [Wikipedia:Conjunctiva#Gross_anatomy] subset: grouping_class synonym: "conjunctiva region" EXACT [] synonym: "region of conjunctiva" EXACT [FMA:59023] xref: FMA:59023 xref: SCTID:29445007 xref: Wikipedia:Conjunctiva#Gross_anatomy is_a: UBERON:0000064 ! organ part intersection_of: UBERON:0000064 ! organ part intersection_of: subdivision_of UBERON:0001811 ! conjunctiva relationship: BFO:0000050 UBERON:0001811 ! part of conjunctiva relationship: subdivision_of UBERON:0001811 ! conjunctiva [Term] id: UBERON:0010312 name: immature eye def: "Developing anatomical structure that develops into the eyeball and associated structures." [ZFA:0001678] synonym: "future eye" EXACT [] xref: TAO:0002201 xref: ZFA:0001678 is_a: BFO:0000002 is_a: UBERON:0005423 ! developing anatomical structure intersection_of: UBERON:0005423 ! developing anatomical structure intersection_of: RO:0002254 UBERON:0003071 ! has developmental contribution from eye primordium relationship: RO:0002202 UBERON:0003071 {evidence="definitional"} ! develops from eye primordium property_value: skos:prefLabel "immature eye" xsd:string [Term] id: UBERON:0010313 name: neural crest-derived structure def: "An anatomical structure that develops from the neural crest." [https://orcid.org/0000-0002-6601-2165] subset: grouping_class is_a: UBERON:0004121 ! ectoderm-derived structure is_a: UBERON:0010314 ! structure with developmental contribution from neural crest intersection_of: UBERON:0000061 ! anatomical structure intersection_of: RO:0002202 UBERON:0002342 ! develops from neural crest relationship: RO:0002202 UBERON:0002342 ! develops from neural crest property_value: skos:prefLabel "neural crest-derived structure" xsd:string [Term] id: UBERON:0010314 name: structure with developmental contribution from neural crest def: "An anatomical structure that has some part that develops from the neural crest." [https://orcid.org/0000-0002-6601-2165] subset: grouping_class is_a: BFO:0000002 is_a: UBERON:0000061 ! anatomical structure intersection_of: UBERON:0000061 ! anatomical structure intersection_of: RO:0002254 UBERON:0002342 ! has developmental contribution from neural crest relationship: RO:0002254 UBERON:0002342 ! has developmental contribution from neural crest property_value: skos:prefLabel "structure with developmental contribution from neural crest" xsd:string [Term] id: UBERON:0010316 name: germ layer / neural crest is_a: BFO:0000002 is_a: UBERON:0002050 ! embryonic structure is_a: UBERON:0005291 ! embryonic tissue relationship: RO:0002202 UBERON:0002532 ! develops from epiblast (generic) property_value: skos:prefLabel "germ layer / neural crest" xsd:string [Term] id: UBERON:0010321 name: skeletal element of eye region def: "A skeletal element that is part of a orbital region." [OBOL:automatic] synonym: "eye skeleton" RELATED [] synonym: "ocular skeleton" RELATED [] synonym: "skeletal element of orbital region" RELATED [] is_a: UBERON:0004765 ! skeletal element is_a: UBERON:0010313 ! neural crest-derived structure intersection_of: UBERON:0004765 ! skeletal element intersection_of: BFO:0000050 UBERON:0004088 ! part of orbital region relationship: BFO:0000050 UBERON:0004088 ! part of orbital region relationship: BFO:0000050 UBERON:0011156 ! part of facial skeleton property_value: skos:prefLabel "skeletal element of eye region" xsd:string [Term] id: UBERON:0010323 name: cranial skeletal system def: "Skeletal subdivision of the head including skull (cranium plus mandible), pharyngeal and/or hyoid apparatus." [GO_REF:0000034, http://dx.plos.org/10.1371/journal.pone.0051070, PSPUB:0000170, VSAO:0000049] synonym: "cranial skeleton" NARROW [] synonym: "cranium" RELATED INCONSISTENT [ZFA:0000737] synonym: "osteocranium" NARROW [] xref: AAO:0000109 xref: AAO:0000971 xref: AAO:0010185 xref: TAO:0000737 xref: VSAO:0000049 xref: XAO:0003075 xref: ZFA:0000737 is_a: UBERON:0000075 ! subdivision of skeletal system relationship: BFO:0000050 UBERON:0011137 ! part of axial skeletal system relationship: RO:0002162 NCBITaxon:89593 ! in taxon Craniata property_value: IAO:0000116 "we use 'cranial skeletal system', so that we can include the skull, which has joints/sutures as parts (recall, we follow FMA in distinguishing between the skeleton and skeletal system - only the latter includes joints)" xsd:string property_value: skos:prefLabel "cranial skeletal system" xsd:string [Term] id: UBERON:0010328 name: limb bud mesenchyme def: "Mesenchyme that is part of a limb bud." [OBOL:automatic] is_a: UBERON:0010329 ! paired limb/fin bud mesenchyme intersection_of: UBERON:0003104 ! mesenchyme intersection_of: BFO:0000050 UBERON:0004347 ! part of limb bud relationship: BFO:0000050 UBERON:0004347 ! part of limb bud [Term] id: UBERON:0010329 name: paired limb/fin bud mesenchyme def: "Mesenchyme that is part of a limb/fin bud." [OBOL:automatic] is_a: UBERON:0010377 ! mesenchyme from somatopleure intersection_of: UBERON:0003104 ! mesenchyme intersection_of: BFO:0000050 UBERON:0004357 ! part of paired limb/fin bud relationship: BFO:0000050 UBERON:0004357 ! part of paired limb/fin bud relationship: RO:0002202 UBERON:0010377 {source="EHDAA2-abduced"} ! develops from mesenchyme from somatopleure property_value: skos:prefLabel "paired limb/fin bud mesenchyme" xsd:string [Term] id: UBERON:0010330 name: eyelid mesenchyme def: "Mesenchyme that is part of a developing eyelid." [OBOL:automatic] xref: EMAPA:32759 is_a: UBERON:0003314 ! eye mesenchyme intersection_of: UBERON:0003104 ! mesenchyme intersection_of: BFO:0000050 UBERON:0001711 ! part of eyelid relationship: BFO:0000050 UBERON:0001711 ! part of eyelid [Term] id: UBERON:0010332 name: epithelium of handplate def: "An epithelium that is part of a handplate." [OBOL:automatic] synonym: "handplate epithelium" EXACT [EHDAA2:0000730] xref: EHDAA2:0000730 xref: EMAPA:32630 is_a: BFO:0000002 is_a: UBERON:0000490 {source="EHDAA2"} ! unilaminar epithelium is_a: UBERON:0005291 ! embryonic tissue intersection_of: UBERON:0000483 ! epithelium intersection_of: BFO:0000050 UBERON:0006875 ! part of embryonic handplate relationship: BFO:0000050 UBERON:0006875 ! part of embryonic handplate relationship: RO:0002202 UBERON:0003372 {source="EHDAA2"} ! develops from pectoral appendage bud ectoderm [Term] id: UBERON:0010333 name: extraembryonic membrane mesenchyme def: "Mesenchyme that is part of a extraembryonic membrane." [OBOL:automatic] is_a: UBERON:0003104 ! mesenchyme is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0005292 ! extraembryonic tissue intersection_of: UBERON:0003104 ! mesenchyme intersection_of: BFO:0000050 UBERON:0005631 ! part of extraembryonic membrane relationship: BFO:0000050 UBERON:0005631 ! part of extraembryonic membrane relationship: RO:0002202 UBERON:0005728 {source="EHDAA2-abduced"} ! develops from extraembryonic mesoderm property_value: skos:prefLabel "extraembryonic membrane mesenchyme" xsd:string [Term] id: UBERON:0010334 name: maxillary process mesenchyme from neural crest def: "Mesenchyme that develops_from a neural crest and is part of a maxillary process mesenchyme." [OBOL:automatic] xref: EHDAA2:0004601 is_a: UBERON:0009526 ! maxillary process mesenchyme is_a: UBERON:0010258 ! mesenchyme from rhombencephalic neural crest intersection_of: UBERON:0003104 ! mesenchyme intersection_of: BFO:0000050 UBERON:0009526 ! part of maxillary process mesenchyme intersection_of: RO:0002202 UBERON:0002342 ! develops from neural crest relationship: BFO:0000050 UBERON:0009526 {source="EHDAA2"} ! part of maxillary process mesenchyme relationship: RO:0002202 UBERON:0010253 {source="EHDAA2"} ! develops from 1st arch maxillary mesenchyme from neural crest property_value: skos:prefLabel "maxillary process mesenchyme from neural crest" xsd:string [Term] id: UBERON:0010335 name: maxillary process mesenchyme from head mesenchyme def: "Mesenchyme that develops_from a head mesenchyme from mesoderm and is part of a maxillary process mesenchyme." [OBOL:automatic] xref: EHDAA2:0004602 is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0009526 ! maxillary process mesenchyme intersection_of: UBERON:0003104 ! mesenchyme intersection_of: BFO:0000050 UBERON:0009526 ! part of maxillary process mesenchyme intersection_of: RO:0002202 UBERON:0006904 ! develops from head mesenchyme from mesoderm relationship: BFO:0000050 UBERON:0009526 {source="EHDAA2"} ! part of maxillary process mesenchyme relationship: RO:0002202 UBERON:0010338 {source="EHDAA2"} ! develops from 1st arch maxillary mesenchyme from head mesenchyme property_value: skos:prefLabel "maxillary process mesenchyme from head mesenchyme" xsd:string [Term] id: UBERON:0010336 name: mandibular process mesenchyme from neural crest def: "Mesenchyme that develops_from a neural crest and is part of a mandibular process mesenchyme." [OBOL:automatic] xref: EHDAA2:0004603 is_a: UBERON:0006905 ! mandibular process mesenchyme is_a: UBERON:0010258 ! mesenchyme from rhombencephalic neural crest intersection_of: UBERON:0003104 ! mesenchyme intersection_of: BFO:0000050 UBERON:0006905 ! part of mandibular process mesenchyme intersection_of: RO:0002202 UBERON:0002342 ! develops from neural crest relationship: BFO:0000050 UBERON:0006905 {source="EHDAA2"} ! part of mandibular process mesenchyme relationship: RO:0002202 UBERON:0010252 {source="EHDAA2"} ! develops from 1st arch mandibular mesenchyme from neural crest property_value: skos:prefLabel "mandibular process mesenchyme from neural crest" xsd:string [Term] id: UBERON:0010337 name: mandibular process mesenchyme from head mesenchyme def: "Mesenchyme that develops_from a head mesenchyme from mesoderm and is part of a mandibular process mesenchyme." [OBOL:automatic] xref: EHDAA2:0004604 is_a: UBERON:0006904 ! head mesenchyme from mesoderm is_a: UBERON:0006905 ! mandibular process mesenchyme intersection_of: UBERON:0003104 ! mesenchyme intersection_of: BFO:0000050 UBERON:0006905 ! part of mandibular process mesenchyme intersection_of: RO:0002202 UBERON:0006904 ! develops from head mesenchyme from mesoderm relationship: BFO:0000050 UBERON:0006905 {source="EHDAA2"} ! part of mandibular process mesenchyme relationship: RO:0002202 UBERON:0010339 {source="EHDAA2"} ! develops from 1st arch mandibular mesenchyme from head mesenchyme property_value: skos:prefLabel "mandibular process mesenchyme from head mesenchyme" xsd:string [Term] id: UBERON:0010338 name: 1st arch maxillary mesenchyme from head mesenchyme def: "Mesenchyme that develops_from a head mesenchyme from mesoderm and is part of a 1st arch maxillary mesenchyme." [OBOL:automatic] xref: EHDAA2:0000043 is_a: UBERON:0010045 ! 1st arch maxillary mesenchyme is_a: UBERON:0010341 ! 1st arch mesenchyme from head mesenchyme intersection_of: UBERON:0003104 ! mesenchyme intersection_of: BFO:0000050 UBERON:0010045 ! part of 1st arch maxillary mesenchyme intersection_of: RO:0002202 UBERON:0006904 ! develops from head mesenchyme from mesoderm relationship: BFO:0000050 UBERON:0010045 {source="EHDAA2"} ! part of 1st arch maxillary mesenchyme property_value: skos:prefLabel "1st arch maxillary mesenchyme from head mesenchyme" xsd:string [Term] id: UBERON:0010339 name: 1st arch mandibular mesenchyme from head mesenchyme def: "Mesenchyme that develops_from a head mesenchyme from mesoderm and is part of a 1st arch mandibular mesenchyme." [OBOL:automatic] xref: EHDAA2:0000036 is_a: UBERON:0009584 ! 1st arch mandibular mesenchyme is_a: UBERON:0010341 ! 1st arch mesenchyme from head mesenchyme intersection_of: UBERON:0003104 ! mesenchyme intersection_of: BFO:0000050 UBERON:0009584 ! part of 1st arch mandibular mesenchyme intersection_of: RO:0002202 UBERON:0006904 ! develops from head mesenchyme from mesoderm relationship: BFO:0000050 UBERON:0009584 {source="EHDAA2"} ! part of 1st arch mandibular mesenchyme property_value: skos:prefLabel "1st arch mandibular mesenchyme from head mesenchyme" xsd:string [Term] id: UBERON:0010341 name: 1st arch mesenchyme from head mesenchyme def: "Mesenchyme that develops_from a head mesenchyme from mesoderm and is part of a 1st arch mesenchyme." [OBOL:automatic] synonym: "mesenchyme derived from head mesoderm of mesenchyme of 1st arch" EXACT [EMAPA:16130] xref: EMAPA:16130 is_a: UBERON:0010042 ! 1st arch mesenchyme is_a: UBERON:0010360 ! pharyngeal arch mesenchyme from head mesenchyme intersection_of: UBERON:0003104 ! mesenchyme intersection_of: BFO:0000050 UBERON:0010042 ! part of 1st arch mesenchyme intersection_of: RO:0002202 UBERON:0006904 ! develops from head mesenchyme from mesoderm relationship: BFO:0000050 UBERON:0010042 {source="EMAPA"} ! part of 1st arch mesenchyme property_value: skos:prefLabel "1st arch mesenchyme from head mesenchyme" xsd:string [Term] id: UBERON:0010343 name: 2nd arch mesenchyme from head mesenchyme def: "Mesenchyme that develops_from a head mesenchyme from mesoderm and is part of a 2nd arch mesenchyme." [OBOL:automatic] synonym: "branchial arch 2 mesenchyme from head mesenchyme" RELATED [] synonym: "head mesenchyme derived arch 2 mesenchyme" EXACT [] synonym: "mesenchyme derived from head mesoderm of mesenchyme of 2nd arch" EXACT [EMAPA:16280] synonym: "pharyngeal arch 2 mesenchyme from head mesenchyme" EXACT [] xref: EHDAA2:0000067 xref: EMAPA:16280 is_a: UBERON:0005689 ! 2nd arch mesenchyme is_a: UBERON:0010360 ! pharyngeal arch mesenchyme from head mesenchyme intersection_of: UBERON:0003104 ! mesenchyme intersection_of: BFO:0000050 UBERON:0005689 ! part of 2nd arch mesenchyme intersection_of: RO:0002202 UBERON:0006904 ! develops from head mesenchyme from mesoderm relationship: BFO:0000050 UBERON:0005689 {source="EHDAA2"} ! part of 2nd arch mesenchyme property_value: skos:prefLabel "2nd arch mesenchyme from head mesenchyme" xsd:string [Term] id: UBERON:0010344 name: 3rd arch mesenchyme from head mesenchyme def: "Mesenchyme that develops_from a head mesenchyme from mesoderm and is part of a 3rd arch mesenchyme." [OBOL:automatic] synonym: "branchial arch 3 mesenchyme from head mesenchyme" RELATED [] synonym: "head mesenchyme derived arch 3 mesenchyme" EXACT [] synonym: "mesenchyme derived from head mesoderm of mesenchyme of 3rd arch" EXACT [EMAPA:16403] synonym: "pharyngeal arch 3 mesenchyme from head mesenchyme" EXACT [] xref: EHDAA2:0000082 xref: EMAPA:16403 is_a: UBERON:0005690 ! 3rd arch mesenchyme is_a: UBERON:0010360 ! pharyngeal arch mesenchyme from head mesenchyme intersection_of: UBERON:0003104 ! mesenchyme intersection_of: BFO:0000050 UBERON:0005690 ! part of 3rd arch mesenchyme intersection_of: RO:0002202 UBERON:0006904 ! develops from head mesenchyme from mesoderm relationship: BFO:0000050 UBERON:0005690 {source="EHDAA2"} ! part of 3rd arch mesenchyme property_value: skos:prefLabel "3rd arch mesenchyme from head mesenchyme" xsd:string [Term] id: UBERON:0010345 name: 4th arch mesenchyme from head mesenchyme def: "Mesenchyme that develops_from a head mesenchyme from mesoderm and is part of a 4th arch mesenchyme." [OBOL:automatic] synonym: "branchial arch 4 mesenchyme from head mesenchyme" RELATED [] synonym: "head mesenchyme derived arch 4 mesenchyme" EXACT [] synonym: "mesenchyme derived from head mesoderm of mesenchyme of 4th arch" EXACT [EMAPA:16771] synonym: "pharyngeal arch 4 mesenchyme from head mesenchyme" EXACT [] xref: EHDAA2:0000097 xref: EMAPA:16771 is_a: UBERON:0005691 ! 4th arch mesenchyme is_a: UBERON:0010360 ! pharyngeal arch mesenchyme from head mesenchyme intersection_of: UBERON:0003104 ! mesenchyme intersection_of: BFO:0000050 UBERON:0005691 ! part of 4th arch mesenchyme intersection_of: RO:0002202 UBERON:0006904 ! develops from head mesenchyme from mesoderm relationship: BFO:0000050 UBERON:0005691 {source="EHDAA2"} ! part of 4th arch mesenchyme property_value: skos:prefLabel "4th arch mesenchyme from head mesenchyme" xsd:string [Term] id: UBERON:0010347 name: 6th arch mesenchyme from head mesenchyme def: "Mesenchyme that develops_from a head mesenchyme from mesoderm and is part of a 6th arch mesenchyme." [OBOL:automatic] synonym: "branchial arch 6 mesenchyme from head mesenchyme" RELATED [] synonym: "head mesenchyme derived arch 6 mesenchyme" EXACT [] synonym: "pharyngeal arch 6 mesenchyme from head mesenchyme" EXACT [] xref: EHDAA2:0004078 is_a: UBERON:0010031 ! 6th arch mesenchyme is_a: UBERON:0010360 ! pharyngeal arch mesenchyme from head mesenchyme intersection_of: UBERON:0003104 ! mesenchyme intersection_of: BFO:0000050 UBERON:0010031 ! part of 6th arch mesenchyme intersection_of: RO:0002202 UBERON:0006904 ! develops from head mesenchyme from mesoderm relationship: BFO:0000050 UBERON:0010031 {source="EHDAA2"} ! part of 6th arch mesenchyme property_value: skos:prefLabel "6th arch mesenchyme from head mesenchyme" xsd:string [Term] id: UBERON:0010349 name: otic capsule pre-cartilage condensation def: "An otic capsule endochondral element that is composed primarily of a pre-cartilage condensation." [OBOL:automatic] synonym: "otic capsule anlage" EXACT [] xref: EHDAA2:0000833 is_a: BFO:0000002 is_a: UBERON:0004637 ! otic capsule intersection_of: UBERON:0004637 ! otic capsule intersection_of: RO:0002473 UBERON:0005866 ! composed primarily of pre-cartilage condensation relationship: RO:0002473 UBERON:0005866 ! composed primarily of pre-cartilage condensation property_value: skos:prefLabel "otic capsule pre-cartilage condensation" xsd:string [Term] id: UBERON:0010355 name: ossification center def: "The first step in ossification of the cartilage is that the cartilage cells, at the point where ossification is commencing and which is termed a ossification center, enlarge and arrange themselves in rows. The matrix in which they are imbedded increases in quantity, so that the cells become further separated from each other. A deposit of calcareous material now takes place in this matrix, between the rows of cells, so that they become separated from each other by longitudinal columns of calcified matrix, presenting a granular and opaque appearance. Here and there the matrix between two cells of the same row also becomes calcified, and transverse bars of calcified substance stretch across from one calcareous column to another. Thus there are longitudinal groups of the cartilage cells enclosed in oblong cavities, the walls of which are formed of calcified matrix which cuts off all nutrition from the cells; the cells, in consequence, atrophy, leaving spaces called the primary areolC&." [Wikipedia:Ossification_center] subset: pheno_slim synonym: "center of ossification" RELATED [Wikipedia:Ossification_center] synonym: "centrum ossificationis" EXACT OMO:0003011 [FMA:TA] synonym: "centrum ossificationis" RELATED OMO:0003011 [Wikipedia:Ossification_center] synonym: "ossification centre" EXACT [FMA:75436] xref: FMA:75436 xref: Wikipedia:Ossification_center is_a: UBERON:0005913 {source="FMA"} ! zone of bone organ property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/f/fd/Gray79.png" xsd:anyURI property_value: IAO:0000116 "currently classified as a zone of a bone organ, but exists prior to bone ossifying" xsd:string property_value: skos:prefLabel "ossification center" xsd:string [Term] id: UBERON:0010358 name: arch of centrum of vertebra def: "An arch-shaped structure of the vertebra that extends dorsally (neural arch) or ventrally (hemal arch) from the vertebral centrum." [http://orcid.org/0000-0002-6601-2165] subset: pheno_slim synonym: "arch of vertebra" NARROW [FMA:11946] synonym: "arcus vertebrae (vertebralis)" NARROW [FMA:11946] synonym: "vertebra arch" NARROW [MA:0001453] synonym: "vertebral arch" NARROW [FMA:11946] xref: EMAPA:36614 is_a: UBERON:0004765 ! skeletal element relationship: BFO:0000050 UBERON:0002412 {source="FMA"} ! part of vertebra [Term] id: UBERON:0010359 name: pharyngeal arch mesenchyme from neural crest def: "Mesenchyme that develops_from a neural crest and is part of a entire pharyngeal arch associated mesenchyme." [OBOL:automatic] comment: Partially implements https://github.com/obophenotype/uberon/wiki/The-neural-crest NC meeting scheme synonym: "arch mesenchyme from neural crest" EXACT [] synonym: "branchial arch mesenchyme from neural crest" EXACT [] synonym: "neural crest derived arch mesenchyme" EXACT [] is_a: UBERON:0005291 ! embryonic tissue is_a: UBERON:0014387 ! mesenchyme derived from neural crest intersection_of: UBERON:0003104 ! mesenchyme intersection_of: BFO:0000050 UBERON:0010046 ! part of entire pharyngeal arch associated mesenchyme intersection_of: RO:0002202 UBERON:0002342 ! develops from neural crest relationship: BFO:0000050 UBERON:0010046 ! part of entire pharyngeal arch associated mesenchyme property_value: skos:prefLabel "pharyngeal arch mesenchyme from neural crest" xsd:string [Term] id: UBERON:0010360 name: pharyngeal arch mesenchyme from head mesenchyme def: "Mesenchyme that develops_from a head mesenchyme from mesoderm and is part of a entire pharyngeal arch associated mesenchyme." [OBOL:automatic] comment: Partially implements https://github.com/obophenotype/uberon/wiki/The-neural-crest NC meeting scheme synonym: "arch mesenchyme from head mesenchyme" EXACT [] synonym: "branchial arch mesenchyme from head mesenchyme" EXACT [] synonym: "head mesenchyme derived arch mesenchyme" EXACT [] is_a: UBERON:0003104 ! mesenchyme is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0005291 ! embryonic tissue intersection_of: UBERON:0003104 ! mesenchyme intersection_of: BFO:0000050 UBERON:0010046 ! part of entire pharyngeal arch associated mesenchyme intersection_of: RO:0002202 UBERON:0006904 ! develops from head mesenchyme from mesoderm relationship: BFO:0000050 UBERON:0010046 ! part of entire pharyngeal arch associated mesenchyme relationship: RO:0002202 UBERON:0006904 ! develops from head mesenchyme from mesoderm property_value: skos:prefLabel "pharyngeal arch mesenchyme from head mesenchyme" xsd:string [Term] id: UBERON:0010362 name: endoskeleton def: "Skeletal subdivision that undergoes indirect development and includes elements that develop as a replacement or substitution of other elements or tissues." [GO_REF:0000034, http://dx.plos.org/10.1371/journal.pone.0051070, PSPUB:0000170, VSAO:0000037] synonym: "replacement skeleton" EXACT [VSAO:curator] xref: VSAO:0000037 xref: Wikipedia:Endoskeleton xref: XAO:0004026 is_a: UBERON:0010912 {source="VSAO"} ! subdivision of skeleton relationship: RO:0002473 UBERON:0010522 ! composed primarily of replacement element property_value: skos:prefLabel "endoskeleton" xsd:string [Term] id: UBERON:0010363 name: endochondral element def: "A skeletal element that has the potential to participate in endochondral ossification, and may participate in intramembranous ossification." [GO_REF:0000034, http://dx.plos.org/10.1371/journal.pone.0051070, PSPUB:0000170, VSAO:0000139] synonym: "endochondral replacement element" EXACT [VSAO:0000139] xref: VSAO:0000139 xref: XAO:0004017 xref: ZFA:0005620 is_a: UBERON:0004765 {source="VSAO"} ! skeletal element property_value: seeAlso "https://github.com/obophenotype/uberon/wiki/Modeling-endochondral-elements-Design-Pattern" xsd:anyURI property_value: skos:prefLabel "endochondral element" xsd:string [Term] id: UBERON:0010364 name: dermal skeleton def: "Skeletal subdivision that undergoes direct development and includes elements that either develop in association with the basement membrane of the ectoderm or are homologous with such elements; includes dermatocranium, components of the appendicular skeleton, teeth and tooth-like elements of the oropharynx, and integumentary elements." [GO_REF:0000034, http://dx.plos.org/10.1371/journal.pone.0051070, PSPUB:0000170, VSAO:0000035] comment: This ontology covers metazoa, so we do not use exoskeleton as primary label, as in VSAO synonym: "dermal skeletal system" RELATED [VSAO:curator] synonym: "dermoskeleton" RELATED [VSAO:curator] synonym: "desmoskeleton" RELATED [VSAO:curator] synonym: "exoskeleton" BROAD INCONSISTENT [VSAO:curator] xref: VSAO:0000035 xref: XAO:0004025 is_a: UBERON:0010912 {source="VSAO"} ! subdivision of skeleton relationship: RO:0002162 NCBITaxon:7742 ! in taxon Vertebrata property_value: skos:prefLabel "dermal skeleton" xsd:string [Term] id: UBERON:0010365 name: odontoid tissue def: "Skeletal tissue that is part of the exoskeleton and derived from an odontogenic papilla." [GO_REF:0000034, http://dx.plos.org/10.1371/journal.pone.0051070, PSPUB:0000170, VSAO:0000063] subset: uberon_slim synonym: "dental tissue" RELATED [VSAO:curator] synonym: "odontogenic tissue" EXACT [VSAO:curator] synonym: "portion of substance of tooth" NARROW [FMA:63001] synonym: "substance of tooth" NARROW [FMA:63001] synonym: "tooth hard tissue" RELATED [VT:0003930] synonym: "tooth substance" NARROW [MA:0002540] synonym: "tooth tissue" RELATED [] xref: EMAPA:35872 xref: FMA:63001 xref: MA:0002540 xref: NCIT:C33794 xref: UMLS:C1519551 {source="ncithesaurus:Tooth_Tissue"} xref: VSAO:0000063 xref: XAO:0004046 xref: ZFA:0005623 is_a: UBERON:0004755 ! skeletal tissue intersection_of: UBERON:0004755 ! skeletal tissue intersection_of: BFO:0000050 UBERON:0010364 ! part of dermal skeleton intersection_of: RO:0002202 UBERON:0001763 ! develops from odontogenic papilla relationship: BFO:0000050 UBERON:0010364 ! part of dermal skeleton relationship: RO:0002202 UBERON:0001763 ! develops from odontogenic papilla relationship: RO:0002433 UBERON:0001091 ! contributes to morphology of calcareous tooth [Term] id: UBERON:0010366 name: conjunctival vasculature def: "A vasculature that is part of a conjunctiva." [OBOL:automatic] synonym: "conjunctival veins" EXACT [FMA:70887] synonym: "conjunctival veins set" EXACT [FMA:70887] synonym: "set of conjunctival veins" EXACT [FMA:70887] synonym: "venae conjunctivales" EXACT OMO:0003011 [FMA:TA] xref: FMA:70887 is_a: UBERON:0002203 ! vasculature of eye intersection_of: UBERON:0002049 ! vasculature intersection_of: BFO:0000050 UBERON:0001811 ! part of conjunctiva relationship: BFO:0000050 UBERON:0001811 ! part of conjunctiva [Term] id: UBERON:0010367 name: conjunctival vein def: "A vein that is part of a conjunctiva." [OBOL:automatic] synonym: "conjunctival blood vessel" BROAD [] xref: SCTID:149885003 is_a: UBERON:0003496 ! head blood vessel is_a: UBERON:0009141 ! craniocervical region vein intersection_of: UBERON:0001638 ! vein intersection_of: BFO:0000050 UBERON:0001811 ! part of conjunctiva relationship: BFO:0000050 UBERON:0010366 ! part of conjunctival vasculature [Term] id: UBERON:0010368 name: pulmonary lobule def: "The smallest anatomical unit of the lung, measuring 0.50 to 2.00 cm in diameter. Each lobule is composed of 4-8 terminal bronchioles and their distal alveolar ducts and sacs. The lobules are separated by fibrous interlobular septa." [ncithesaurus:Pulmonary_Lobule] synonym: "lobulus pulmonis" EXACT OMO:0003011 [FMA:75739, FMA:TA] xref: FMA:75739 xref: NCIT:C33428 is_a: UBERON:0009911 ! lobule intersection_of: UBERON:0009911 ! lobule intersection_of: BFO:0000050 UBERON:0002048 ! part of lung relationship: BFO:0000050 UBERON:8600017 ! part of bronchopulmonary segment property_value: skos:prefLabel "pulmonary lobule" xsd:string [Term] id: UBERON:0010369 name: secondary pulmonary lobule def: "A unit of lung supplied by three to five terminal bronchioles and contained by fibrous septa." [PMID:3259815] subset: human_reference_atlas synonym: "lobulus pulmonis secondarius" EXACT OMO:0003011 [FMA:7414, FMA:TA] synonym: "respiratory lobule" RELATED [PMID:18403324] xref: FMA:7414 is_a: UBERON:0010368 {source="FMA"} ! pulmonary lobule relationship: BFO:0000050 UBERON:0008946 {source="FMA"} ! part of lung parenchyma property_value: RO:0002175 NCBITaxon:9606 property_value: terms:contributor https://orcid.org/0000-0001-6677-8489 [Term] id: UBERON:0010370 name: tibial vein def: "One of the veins of the lower leg; empty into the popliteal vein." [http://www.thefreedictionary.com/tibial+vein] synonym: "vena tibialis" EXACT [] xref: EMAPA:37199 {source="MA:th"} xref: MA:0002243 xref: NCIT:C33787 xref: UMLS:C0447138 {source="ncithesaurus:Tibial_Vein"} is_a: UBERON:0001638 {source="MA"} ! vein is_a: UBERON:0003503 ! leg blood vessel [Term] id: UBERON:0010371 name: ecto-epithelium def: "Epithelium composed of cells that develops from the ectoderm[FMA,modified]." [FMA:69064] synonym: "ectoderm-derived epithelium" EXACT [] xref: FMA:69064 is_a: UBERON:0000483 ! epithelium is_a: UBERON:0004121 ! ectoderm-derived structure intersection_of: UBERON:0000483 ! epithelium intersection_of: RO:0002202 UBERON:0000924 ! develops from ectoderm relationship: RO:0002473 CL:0002077 ! composed primarily of ecto-epithelial cell property_value: skos:prefLabel "ecto-epithelium" xsd:string [Term] id: UBERON:0010375 name: pancreas dorsal primordium synonym: "dorsal pancreas" RELATED INCONSISTENT [FMA:79793] xref: EHDAA2:0001384 xref: FMA:79793 is_a: UBERON:0001048 ! primordium is_a: UBERON:0006598 ! presumptive structure intersection_of: UBERON:0001048 ! primordium intersection_of: RO:0002387 UBERON:0009708 ! has potential to develop into dorsal pancreas relationship: BFO:0000050 UBERON:0003921 {source="EHDAA2"} ! part of pancreas primordium relationship: RO:0002387 UBERON:0009708 ! has potential to develop into dorsal pancreas property_value: IAO:0000116 "consider merging with dorsal pancreatic bud. Starts at CS12 in human (EHDAA2, embryology.ch 'bud anlagen')" xsd:string property_value: skos:prefLabel "pancreas dorsal primordium" xsd:string [Term] id: UBERON:0010376 name: pancreas ventral primordium synonym: "ventral pancreas" RELATED INCONSISTENT [FMA:79794] xref: EHDAA2:0001387 xref: FMA:79794 is_a: UBERON:0001048 ! primordium is_a: UBERON:0006598 ! presumptive structure intersection_of: UBERON:0001048 ! primordium intersection_of: RO:0002387 UBERON:0009709 ! has potential to develop into ventral pancreas relationship: BFO:0000050 UBERON:0003921 {source="EHDAA2"} ! part of pancreas primordium relationship: RO:0002387 UBERON:0009709 ! has potential to develop into ventral pancreas property_value: skos:prefLabel "pancreas ventral primordium" xsd:string [Term] id: UBERON:0010377 name: mesenchyme from somatopleure def: "Mesenchyme that develops_from a somatopleure." [OBOL:automatic] xref: EHDAA2:0001120 is_a: UBERON:0005291 ! embryonic tissue is_a: UBERON:0007524 {source="EHDAA2"} ! dense mesenchyme tissue intersection_of: UBERON:0003104 ! mesenchyme intersection_of: BFO:0000050 UBERON:0000922 ! part of embryo intersection_of: RO:0002202 UBERON:0004874 ! develops from somatopleure relationship: BFO:0000050 UBERON:0009142 {source="EHDAA2"} ! part of entire embryonic mesenchyme relationship: RO:0002202 UBERON:0004874 ! develops from somatopleure property_value: IAO:0000116 "the way this class is defined also includes extraembryonic mesenchyme such as the amniotic mesenchyme; in future this may be restricted to embryonic derivatives" xsd:string property_value: skos:prefLabel "mesenchyme from somatopleure" xsd:string [Term] id: UBERON:0010378 name: mesenchyme from splanchnopleure def: "Mesenchyme that develops_from a splanchnopleure." [OBOL:automatic] xref: EHDAA2:0001122 is_a: UBERON:0005291 ! embryonic tissue is_a: UBERON:0007524 {source="EHDAA2"} ! dense mesenchyme tissue intersection_of: UBERON:0003104 ! mesenchyme intersection_of: BFO:0000050 UBERON:0000922 ! part of embryo intersection_of: RO:0002202 UBERON:0004873 ! develops from splanchnopleure relationship: BFO:0000050 UBERON:0009142 {source="EHDAA2"} ! part of entire embryonic mesenchyme relationship: RO:0002202 UBERON:0004873 ! develops from splanchnopleure property_value: skos:prefLabel "mesenchyme from splanchnopleure" xsd:string [Term] id: UBERON:0010380 name: enteric nerve def: "The neurons that innervate the esophagus, stomach, small and large bowel." [MGI:csmith, MP:0001046] subset: pheno_slim xref: EMAPA:37479 {source="MA:th"} xref: MA:0001145 is_a: UBERON:0001021 ! nerve intersection_of: UBERON:0001021 ! nerve intersection_of: BFO:0000050 UBERON:0002005 ! part of enteric nervous system relationship: BFO:0000050 UBERON:0002005 ! part of enteric nervous system relationship: RO:0002433 UBERON:0002005 ! contributes to morphology of enteric nervous system [Term] id: UBERON:0010386 name: Peyer's patch follicle def: "A lymphoid follicle that is part of a Peyer's patch." [OBOL:automatic] subset: pheno_slim synonym: "Peyer's patch follicle" EXACT [MA:0000732] xref: MA:0000732 is_a: UBERON:0000444 ! lymphoid follicle intersection_of: UBERON:0000444 ! lymphoid follicle intersection_of: BFO:0000050 UBERON:0001211 ! part of Peyer's patch relationship: BFO:0000050 UBERON:0001211 ! part of Peyer's patch relationship: RO:0002433 UBERON:0001211 ! contributes to morphology of Peyer's patch [Term] id: UBERON:0010387 name: Peyer's patch T cell area def: "The Peyer's patch area normally occupied by T lymphocytes." [MP:0002392] subset: pheno_slim xref: EMAPA:37939 {source="MA:th"} is_a: UBERON:0010393 ! T cell domain is_a: UBERON:0013765 ! digestive system element intersection_of: UBERON:0010393 ! T cell domain intersection_of: BFO:0000050 UBERON:0001211 ! part of Peyer's patch relationship: BFO:0000050 UBERON:0001211 ! part of Peyer's patch [Term] id: UBERON:0010388 name: proximal segment of rib def: "The segment of the rib that connects to a vertebra[MP]. a small part of the rib composed of the head, neck, tuberculum and a short proximal part of the body[PMID]." [MP:0000152, PMID:15906248] comment: The proximal rib derives from the caudal half of somite[PMID:15906248] subset: pheno_slim synonym: "costal part of rib" RELATED [] synonym: "proximal part of rib" EXACT [PMID:15906248] synonym: "proximal rib" EXACT [MA:0001400] synonym: "proximal rib segment" EXACT [] synonym: "vertebral part of rib" RELATED [] xref: EMAPA:37495 {source="MA:th"} xref: MA:0001400 is_a: UBERON:0005913 ! zone of bone organ relationship: BFO:0000050 UBERON:0002228 {source="MA"} ! part of rib relationship: RO:0002170 UBERON:0002412 ! connected to vertebra [Term] id: UBERON:0010390 name: lumen of urethra def: "An organ cavity that is part of a urethra." [OBOL:automatic] synonym: "urethral lumen" EXACT [FMA:19709] xref: FMA:19709 xref: SCTID:279432008 is_a: UBERON:0000464 ! anatomical space intersection_of: UBERON:0000464 ! anatomical space intersection_of: RO:0002572 UBERON:0000057 ! luminal space of urethra relationship: RO:0002572 UBERON:0000057 ! luminal space of urethra [Term] id: UBERON:0010392 name: B cell domain is_a: UBERON:0010394 ! lymphocyte domain intersection_of: UBERON:0010394 ! lymphocyte domain intersection_of: BFO:0000051 CL:0000236 ! has part B cell relationship: BFO:0000051 CL:0000236 ! has part B cell property_value: IAO:0000116 "TODO - check" xsd:string [Term] id: UBERON:0010393 name: T cell domain is_a: UBERON:0010394 ! lymphocyte domain intersection_of: UBERON:0010394 ! lymphocyte domain intersection_of: BFO:0000051 CL:0000084 ! has part T cell relationship: BFO:0000051 CL:0000084 ! has part T cell property_value: IAO:0000116 "TODO - check" xsd:string [Term] id: UBERON:0010394 name: lymphocyte domain is_a: BFO:0000002 is_a: UBERON:0005057 ! immune organ is_a: UBERON:0010001 ! cell cluster organ intersection_of: UBERON:0010001 ! cell cluster organ intersection_of: RO:0002473 CL:0000542 ! composed primarily of lymphocyte relationship: BFO:0000050 UBERON:0002465 ! part of lymphoid system relationship: RO:0002473 CL:0000542 ! composed primarily of lymphocyte property_value: IAO:0000116 "TODO - check" xsd:string property_value: seeAlso "https://github.com/obophenotype/uberon/issues/513" xsd:anyURI [Term] id: UBERON:0010395 name: lymph node primary follicle def: "An unstimulated network of follicular dendritic cells and small resting B cells in the lymph node cortex." [https://github.com/obophenotype/uberon/issues/6, MP:0002345] subset: human_reference_atlas subset: pheno_slim synonym: "primary follicle of lymph node" EXACT [] xref: EMAPA:35530 xref: FMA:312350 xref: MA:0000743 is_a: UBERON:0010422 ! primary nodular lymphoid tissue is_a: UBERON:0010748 ! lymph node follicle intersection_of: UBERON:0010422 ! primary nodular lymphoid tissue intersection_of: BFO:0000050 UBERON:0000029 ! part of lymph node property_value: RO:0002175 NCBITaxon:9606 property_value: terms:contributor https://orcid.org/0000-0002-6601-2165 property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 [Term] id: UBERON:0010397 name: efferent lymphatic vessel def: "Lymphatic vessel that exits the lymph node. The efferent lymphatic vessel commences from the lymph sinuses of the medullary portion of the lymph nodes and leave the lymph nodes either to veins or greater nodes. Efferent lymphatic vessels are also found in the thymus and spleen. This is in contrast to afferent lymphatic vessels, which are found only in lymph nodes." [MP:MP] subset: human_reference_atlas subset: pheno_slim synonym: "efferent lymphatic vessel" RELATED [Wikipedia:Efferent_lymph_vessel] synonym: "efferent lymphatic vessels" RELATED [Wikipedia:Efferent_lymph_vessel] xref: MA:0000749 xref: Wikipedia:Efferent_lymph_vessel is_a: UBERON:0001473 ! lymphatic vessel property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/lymph-node-female/v1.4/assets/3d-nih-f-lymph-node.glb" xsd:anyURI property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/lymph-node-male/v1.4/assets/3d-nih-m-lymph-node.glb" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0010399 name: spleen trabecular artery def: "One of the branches of the splenic artery[MP]." [MP:0002354, Wikipedia:Trabecular_arteries] subset: human_reference_atlas subset: pheno_slim synonym: "trabecular artery" RELATED [] xref: MA:0000759 xref: NCIT:C49775 xref: UMLS:C1710159 {source="ncithesaurus:Splenic_Trabecular_Artery"} xref: Wikipedia:Trabecular_arteries is_a: UBERON:0001637 ! artery is_a: UBERON:0003497 ! abdomen blood vessel intersection_of: UBERON:0001637 ! artery intersection_of: BFO:0000050 UBERON:0001265 ! part of trabecula of spleen relationship: BFO:0000050 UBERON:0001265 ! part of trabecula of spleen relationship: RO:0002252 UBERON:0001194 {source="MP"} ! connecting branch of splenic artery relationship: RO:0002433 UBERON:0002106 ! contributes to morphology of spleen property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "spleen trabecular artery" xsd:string [Term] id: UBERON:0010400 name: spleen trabecular vein def: "One of the veins that feed the splenic vein." [MP:0002228, Wikipedia:Trabecular_veins] subset: human_reference_atlas subset: pheno_slim synonym: "trabecular vein" RELATED [Wikipedia:Trabecular_veins] xref: MA:0000760 xref: NCIT:C49779 xref: UMLS:C1710160 {source="ncithesaurus:Splenic_Trabecular_Vein"} xref: Wikipedia:Trabecular_veins is_a: UBERON:0013126 ! vein of abdomen intersection_of: UBERON:0001638 ! vein intersection_of: BFO:0000050 UBERON:0001265 ! part of trabecula of spleen relationship: BFO:0000050 UBERON:0001265 ! part of trabecula of spleen relationship: RO:0002170 UBERON:0003713 ! connected to splenic vein relationship: RO:0002433 UBERON:0002106 ! contributes to morphology of spleen property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "spleen trabecular vein" xsd:string [Term] id: UBERON:0010402 name: epidermis suprabasal layer def: "Any layer of the epidermis that is superior to the stratum basale." [http://orcid.org/0000-0002-6601-2165, MP:0001233, PMID:10469309] subset: pheno_slim synonym: "suprabasal cell layer of skin" EXACT [] synonym: "suprabasal layer" BROAD [MP:0001233] synonym: "suprabasal layer of epidermis" EXACT [] xref: EMAPA:35315 xref: MA:0000808 is_a: UBERON:0013754 ! integumentary system layer intersection_of: UBERON:0013754 ! integumentary system layer intersection_of: BFO:0000050 UBERON:0001003 ! part of skin epidermis intersection_of: BSPO:0000108 UBERON:0002025 ! stratum basale of epidermis relationship: BFO:0000050 UBERON:0001003 ! part of skin epidermis relationship: BSPO:0000108 UBERON:0002025 ! stratum basale of epidermis [Term] id: UBERON:0010403 name: brain marginal zone def: "The part of the future brain that is derived from the mantle layer of the neural tube." [http://orcid.org/0000-0002-6601-2165] subset: pheno_slim synonym: "brain marginal zone" BROAD [MA:0000812] xref: DHBA:10508 xref: EMAPA:32680 xref: MA:0000812 is_a: BFO:0000002 is_a: UBERON:0005423 ! developing anatomical structure relationship: BFO:0000050 UBERON:0000955 ! part of brain relationship: RO:0002202 UBERON:0004062 ! develops from neural tube marginal layer property_value: skos:prefLabel "brain marginal zone" xsd:string [Term] id: UBERON:0010409 name: ocular surface region def: "The integrated unit (of the eye) that consists of the conjunctiva, the corneal surface, and the ocular mucosal adnexa including the lid margins and the meibomian gland openings, the lacrimal glands and the lacrimal drainage system, all which are critical to maintain ocular surface integrity and provide protection from external antigens and pathogenic microorganisms." [MP:0013754] subset: pheno_slim synonym: "eye surface" EXACT [MA:0002486] synonym: "eye surface region" EXACT [] synonym: "ocular surface" EXACT [] xref: EMAPA:35336 xref: MA:0002486 is_a: UBERON:0000063 ! organ subunit relationship: BFO:0000050 UBERON:0000019 ! part of camera-type eye relationship: BSPO:0000108 UBERON:0022288 ! surface of eyeball property_value: skos:prefLabel "ocular surface region" xsd:string [Term] id: UBERON:0010416 name: lymph node B cell domain def: "A part of the lymph node cortex in which B lymphocytes home to primary follicles to survey follicular dendritic cells (FDCs); antigen stimulated B cells proliferate and differentiate within the follicles forming distinctive germinal centers." [MP:MP] subset: pheno_slim synonym: "lymph node B cell dependent cortex" EXACT [MP:0002344] synonym: "lymph node B-cell domain" EXACT [MP:0002344] synonym: "nodular lymph node cortex" EXACT [MP:0002344] xref: MA:0002851 is_a: UBERON:0010392 ! B cell domain intersection_of: UBERON:0010392 ! B cell domain intersection_of: BFO:0000050 UBERON:0000029 ! part of lymph node relationship: BFO:0000050 UBERON:0002006 {source="MP"} ! part of cortex of lymph node [Term] id: UBERON:0010417 name: lymph node T cell domain def: "The paracortex and interfollicular cortex of the lymph node in which T lymphocytes home to survey dendritic cells." [MP:0002347] subset: pheno_slim synonym: "lymph node deep cortex" EXACT [MP:0002347] synonym: "lymph node T cell dependent paracortex" EXACT [MP:0002347] synonym: "lymph node T zone" EXACT [] synonym: "lymph node T-cell domain" EXACT [MP:0002347] synonym: "T cell zone of lymph node" EXACT [] synonym: "T zone of lymph node" EXACT [] xref: EMAPA:37663 {source="MA:th"} xref: MA:0002852 xref: SCTID:326870003 is_a: UBERON:0010393 ! T cell domain intersection_of: UBERON:0010393 ! T cell domain intersection_of: BFO:0000050 UBERON:0000029 ! part of lymph node relationship: BFO:0000050 UBERON:0002006 {source="MP"} ! part of cortex of lymph node property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/lymph-node-female/v1.4/assets/3d-nih-f-lymph-node.glb" xsd:anyURI property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/lymph-node-male/v1.4/assets/3d-nih-m-lymph-node.glb" xsd:anyURI [Term] id: UBERON:0010418 name: urethral opening def: "An orifice that is part of a lower urinary tract." [OBOL:automatic] subset: pheno_slim synonym: "urethral orifice" EXACT [OBOL:automatic] xref: EMAPA:35965 xref: MA:0002867 is_a: UBERON:0000161 ! orifice intersection_of: UBERON:0000161 ! orifice intersection_of: BFO:0000050 UBERON:0001556 ! part of lower urinary tract relationship: BFO:0000050 UBERON:0001556 ! part of lower urinary tract [Term] id: UBERON:0010420 name: lymph node germinal center mantle zone def: "A part of the secondary follicle in which naive B cells reside along with some helper T cells, macrophages and follicular dendritic cells; these are displaced by the expanding germinal centre and form a 'mantle' around it." [http://orcid.org/0000-0003-4183-8865, https://github.com/obophenotype/uberon/issues/7, https://orcid.org/0000-0001-9990-8331, MP:MP, PMID:25656706] subset: human_reference_atlas subset: pheno_slim synonym: "germinal center mantle zone" BROAD [] synonym: "lymph node B cell corona" EXACT [CL:tm] synonym: "lymph node dark zone" RELATED [CL:tm] synonym: "lymph node follicular corona" EXACT [] synonym: "lymph node follicular mantle" EXACT [MA:0002990] synonym: "lymph node inactive zone" EXACT [CL:tm] synonym: "lymph node peripheral zone" EXACT [CL:tm] synonym: "mantle zone of germinal center" BROAD [] synonym: "mantle zone of lymph node germinal center" EXACT [] xref: EMAPA:37661 {source="MA:th"} xref: MA:0002990 is_a: UBERON:0010755 ! secondary follicle corona intersection_of: UBERON:0010755 ! secondary follicle corona intersection_of: BFO:0000050 UBERON:0000029 ! part of lymph node relationship: BFO:0000050 UBERON:0010753 {source="MA"} ! part of lymph node secondary follicle relationship: RO:0002221 UBERON:0009039 ! surrounds lymph node germinal center property_value: RO:0002175 NCBITaxon:9606 property_value: terms:contributor https://orcid.org/0000-0002-6601-2165 property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 [Term] id: UBERON:0010421 name: spleen B cell corona def: "The area of the (spleen) secondary B follicle that surrounds the germinal center and harbors the small recirculating B lymphocytes." [CL:tm, https://github.com/obophenotype/uberon/issues/6, PMID:17495967] subset: human_reference_atlas subset: pheno_slim synonym: "B cell domain of the spleen" BROAD [MP:0002360] synonym: "B lymphocyte domain of the spleen" BROAD [] synonym: "follicle mantle" EXACT [MP:0002360] synonym: "lymphocytic corona" BROAD [CL:tm, MP:0002360] synonym: "spleen B cell corona" EXACT [MP:0002360] synonym: "spleen B-cell corona" EXACT [MP:0002360] synonym: "spleen lymphocytic corona" EXACT [CL:tm, MP:0002360] synonym: "spleen mantle zone" RELATED [CL:tm, MP:0002360] synonym: "splenic B cell corona" EXACT [MP:0002360] synonym: "splenic corona" BROAD [CL:tm] xref: EMAPA:37962 {source="MA:th"} is_a: UBERON:0010755 ! secondary follicle corona intersection_of: UBERON:0010755 ! secondary follicle corona intersection_of: BFO:0000050 UBERON:0002106 ! part of spleen relationship: BFO:0000050 UBERON:0004042 {source="CL:tm"} ! part of spleen secondary B follicle relationship: RO:0002221 UBERON:0005196 ! surrounds spleen germinal center relationship: RO:0002433 UBERON:0004042 ! contributes to morphology of spleen secondary B follicle property_value: RO:0002175 NCBITaxon:9606 property_value: terms:contributor https://orcid.org/0000-0002-6601-2165 property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 [Term] id: UBERON:0010422 name: primary nodular lymphoid tissue def: "A lymphoid follicle containing naive B cells." [CL:tm] synonym: "primary follicle" RELATED [] synonym: "primary lymphoid follicle" EXACT [] synonym: "primary lymphoid nodule" EXACT [FMA:55223] xref: FMA:55223 is_a: UBERON:0000444 {source="FMA"} ! lymphoid follicle relationship: BFO:0000051 CL:0000788 {source="CL:tm"} ! has part naive B cell [Term] id: UBERON:0010423 name: primary lymphoid nodule of tonsil def: "A primary nodular lymphoid tissue that is part of a tonsil." [OBOL:automatic] subset: human_reference_atlas synonym: "lymphoid nodule of tonsil" RELATED [FMA:86018] xref: FMA:86018 is_a: UBERON:0010422 {source="FMA"} ! primary nodular lymphoid tissue intersection_of: UBERON:0010422 ! primary nodular lymphoid tissue intersection_of: BFO:0000050 UBERON:0002372 ! part of tonsil relationship: BFO:0000050 UBERON:0002372 ! part of tonsil property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0010425 name: internal naris def: "A naris that is located inside the nasal cavity and connects to the pharynx." [http://orcid.org/0000-0002-6601-2165] subset: pheno_slim synonym: "choana" EXACT [] synonym: "choanae" RELATED OMO:0003004 [] synonym: "internal choana" EXACT [] synonym: "internal nares" RELATED OMO:0003004 [] synonym: "internal nostril" RELATED [] xref: NCIT:C32856 is_a: UBERON:0000003 ! naris intersection_of: UBERON:0000003 ! naris intersection_of: RO:0002176 UBERON:0001707 ! connects nasal cavity intersection_of: RO:0002176 UBERON:0006562 ! connects pharynx relationship: RO:0002162 NCBITaxon:8287 ! in taxon Sarcopterygii relationship: RO:0002176 UBERON:0006562 ! connects pharynx [Term] id: UBERON:0010427 name: ciliary processes def: "The ciliary processes are formed by the inward folding of the various layers of the choroid, i.e. , the choroid proper and the lamina basalis, and are received between corresponding foldings of the suspensory ligament of the lens." [Wikipedia:Ciliary_processes] synonym: "ciliary process" RELATED [Wikipedia:Ciliary_processes] synonym: "ciliary processes" EXACT [FMA:76551] synonym: "ciliary processes set" EXACT [FMA:76551] synonym: "processus ciliares" EXACT OMO:0003011 [FMA:TA] synonym: "processus ciliares" RELATED OMO:0003011 [Wikipedia:Ciliary_processes] synonym: "set of ciliary processes" EXACT [FMA:76551] xref: FMA:76551 xref: SCTID:280860001 xref: Wikipedia:Ciliary_processes is_a: UBERON:0000481 ! multi-tissue structure relationship: BFO:0000050 UBERON:0001775 ! part of ciliary body property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/b/b2/Gray875.png" xsd:anyURI property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/eye-female-left/v1.3/assets/3d-vh-f-eye-l.glb" xsd:anyURI property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/eye-female-right/v1.3/assets/3d-vh-f-eye-r.glb" xsd:anyURI property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/eye-male-left/v1.3/assets/3d-vh-m-eye-l.glb" xsd:anyURI property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/eye-male-right/v1.3/assets/3d-vh-m-eye-r.glb" xsd:anyURI property_value: skos:prefLabel "ciliary processes" xsd:string [Term] id: UBERON:0010428 name: flat bone def: "A bone that is shaped as a broad flat plate and composed of two thin layers of compact tissue enclosing between them a variable quantity of cancellous tissue, which is the location of red bone marrow." [Wikipedia:Flat_bone] comment: Examples: cranium, the ilium, sternum, rib cage, the sacrum and the scapula; the occipital, parietal, frontal, nasal, lacrimal, vomer, scapula, os coxC&, sternum, and ribs synonym: "os planum" RELATED OMO:0003011 [Wikipedia:Flat_bone] xref: FMA:7476 xref: galen:FlatBone xref: NCIT:C32616 xref: SCTID:332907008 xref: UMLS:C0222649 {source="ncithesaurus:Flat_Bone"} xref: Wikipedia:Flat_bone is_a: UBERON:0001474 {source="FMA"} ! bone element relationship: RO:0000086 PATO:0000407 ! has quality flat property_value: skos:prefLabel "flat bone" xsd:string [Term] id: UBERON:0010498 name: pseudostratified columnar epithelium def: "A simple columnar epithelium that looks stratified but is not, because its cells are arranged with their nuclei at different levels." [http://medical-dictionary.thefreedictionary.com/pseudostratified+epithelium, Wikipedia:Pseudostratified_columnar_epithelium] xref: FMA:45572 xref: NCIT:C33419 xref: NCIT:C49316 xref: UMLS:C0836138 {source="ncithesaurus:Pseudostratified_Columnar_Epithelium"} xref: UMLS:C1514590 {source="ncithesaurus:Pseudostratified_Epithelium"} xref: Wikipedia:Pseudostratified_columnar_epithelium is_a: UBERON:0000485 {source="FMA"} ! simple columnar epithelium property_value: skos:prefLabel "pseudostratified columnar epithelium" xsd:string [Term] id: UBERON:0010499 name: pseudostratified ciliated columnar epithelium def: "Epithelium composed of a single layer of cells, appearing as layered because the column-shaped cells vary in height so the nuclei are at different levels. The basal portions of all the cells are in contact with the basement membrane. It lines the respiratory system and the male reproductive tract. The cilia in the respiratory tract are motile, while the stereocilia in the male reproductive tract are immobile." [NCIT:NCIT] synonym: "epithelium pseudostratificatum columnare ciliatum (trachea et bronchi)" EXACT [FMA:13146] xref: FMA:13146 xref: NCIT:C13181 xref: UMLS:C0506992 {source="ncithesaurus:Pseudostratified_Columnar_Ciliated_Epithelium"} is_a: UBERON:0007592 ! ciliated columnar epithelium is_a: UBERON:0010498 ! pseudostratified columnar epithelium intersection_of: UBERON:0010498 ! pseudostratified columnar epithelium intersection_of: BFO:0000051 CL:0000067 ! has part ciliated epithelial cell property_value: skos:prefLabel "pseudostratified ciliated columnar epithelium" xsd:string [Term] id: UBERON:0010521 name: electroreceptor organ def: "An organ that is capable of detecting electrical stimulus." [http://orcid.org/0000-0002-6601-2165] synonym: "electric sense organ" EXACT [] synonym: "electroreception organ" EXACT [] is_a: UBERON:0000020 ! sense organ intersection_of: UBERON:0000062 ! organ intersection_of: RO:0002215 GO:0050964 ! capable of detection of electrical stimulus involved in electroception relationship: RO:0002215 GO:0050964 ! capable of detection of electrical stimulus involved in electroception [Term] id: UBERON:0010522 name: replacement element def: "Skeletal element that forms as a replacement or substitution of another element or tissue." [GO_REF:0000034, http://dx.plos.org/10.1371/journal.pone.0051070, PSPUB:0000170, VSAO:0000135] xref: VSAO:0000135 xref: XAO:0004016 xref: ZFA:0005624 is_a: UBERON:0004765 {source="VSAO"} ! skeletal element relationship: BFO:0000050 UBERON:0010362 {source="cjm"} ! part of endoskeleton property_value: skos:prefLabel "replacement element" xsd:string [Term] id: UBERON:0010523 name: microcirculatory vessel def: "A vessel of the microcirculature, lying between the arterioles and venules; includes capillaries (blood and lymphatic), metarterioles and arteriovenous anastomoses." [http://orcid.org/0000-0002-6601-2165, MESH:A07.231.432, ZFA:0005251] synonym: "microcirculatory vessels" RELATED OMO:0003004 [TAO:0005251] xref: MESH:D055806 xref: TAO:0005251 xref: ZFA:0005251 is_a: UBERON:0000055 ! vessel relationship: BFO:0000050 UBERON:0002049 {source="ZFA"} ! part of vasculature property_value: skos:prefLabel "microcirculatory vessel" xsd:string [Term] id: UBERON:0010527 name: cavity of bone organ def: "An organ cavity that surrounded_by a bone." [OBOL:automatic] synonym: "bone organ cavity" EXACT [FMA:24021] xref: FMA:24021 is_a: UBERON:0002558 ! organ cavity intersection_of: UBERON:0002558 ! organ cavity intersection_of: BFO:0000050 UBERON:0001474 ! part of bone element relationship: BFO:0000050 UBERON:0001474 ! part of bone element property_value: skos:prefLabel "cavity of bone organ" xsd:string [Term] id: UBERON:0010528 name: pneumatic cavity of bone synonym: "air space of bone" EXACT [FMA:24028] xref: FMA:24028 is_a: UBERON:0010527 {source="FMA"} ! cavity of bone organ relationship: BFO:0000050 UBERON:0008193 ! part of pneumatized bone property_value: skos:prefLabel "pneumatic cavity of bone" xsd:string [Term] id: UBERON:0010531 name: metanephros induced blastemal cells synonym: "cap mesenchyme of metanephros of urinary system" RELATED [EMAPA:17645] synonym: "induced blastemal cells" EXACT [VHOG:0001241] synonym: "nephrogenic interstitium" RELATED [] synonym: "nephrogenic interstitium of nephrogenic zone" EXACT [EMAPA:17953] synonym: "peripheral blastema" RELATED [EMAPA:17953] xref: EHDAA2:0001143 xref: EHDAA:7007 xref: EHDAA:8105 xref: EMAPA:17953 xref: MA:0002998 xref: VHOG:0001241 is_a: BFO:0000002 is_a: UBERON:0005423 ! developing anatomical structure relationship: BFO:0000050 UBERON:0009871 ! part of nephrogenic zone relationship: BFO:0000051 CL:0000354 ! has part blastemal cell relationship: RO:0002202 UBERON:0003220 {source="EHDAA2"} ! develops from metanephric mesenchyme relationship: RO:0002256 UBERON:0000084 ! developmentally induced by ureteric bud [Term] id: UBERON:0010532 name: primitive nephron def: "An epithelial tube that is fated to become a nephron." [http://orcid.org/0000-0002-6601-2165] synonym: "developing nephron" BROAD [] synonym: "future nephron" EXACT [] synonym: "presumptive nephron" EXACT [] synonym: "primitive nephron" BROAD [] is_a: BFO:0000002 is_a: UBERON:0003914 {source="EHDAA2-inferred"} ! epithelial tube is_a: UBERON:0004819 ! kidney epithelium is_a: UBERON:0006555 ! excretory tube relationship: RO:0001025 UBERON:0003918 ! located in kidney mesenchyme relationship: RO:0002202 UBERON:0004209 {source="EHDAA2"} ! develops from renal vesicle relationship: RO:0002387 UBERON:0001285 ! has potential to develop into nephron [Term] id: UBERON:0010533 name: metanephros cortex def: "The metanephric cortex is the outer region of the metanephros[GO]." [GO:0072214] xref: VHOG:0000714 is_a: UBERON:0001225 ! cortex of kidney is_a: UBERON:0004120 ! mesoderm-derived structure intersection_of: UBERON:0001225 ! cortex of kidney intersection_of: BFO:0000050 UBERON:0000081 ! part of metanephros relationship: BFO:0000050 UBERON:0000081 {source="VHOG"} ! part of metanephros relationship: RO:0002202 UBERON:0005113 ! develops from metanephric cortex mesenchyme [Term] id: UBERON:0010534 name: primitive mesonephric nephron def: "Anatomical cluster which give rise to mature mesonephric nephrons. Zebrafish continously generate new mesonephric nephrons." [GOC:cvs, https://orcid.org/0000-0002-2244-7917, ZFA:0005584] synonym: "developing mesonephric nephron" EXACT [ZFA:0005584] synonym: "primitive mesonephric nephron" EXACT [] xref: ZFA:0005584 is_a: UBERON:0000083 ! mesonephric tubule is_a: UBERON:0010532 ! primitive nephron intersection_of: UBERON:0010532 ! primitive nephron intersection_of: BFO:0000050 UBERON:0000080 ! part of mesonephros [Term] id: UBERON:0010535 name: primitive metanephric nephron def: "A primitive nephron that is part of a metanephros." [OBOL:automatic] synonym: "developing metanephric nephron" EXACT [] synonym: "primitive metanephric nephron" EXACT [] synonym: "primitive nephron" BROAD [EHDAA2:0001516] xref: EHDAA2:0001516 is_a: UBERON:0005106 ! metanephric tubule is_a: UBERON:0010532 ! primitive nephron intersection_of: UBERON:0010532 ! primitive nephron intersection_of: BFO:0000050 UBERON:0000081 ! part of metanephros relationship: BFO:0000050 UBERON:0005113 {source="EHDAA2"} ! part of metanephric cortex mesenchyme [Term] id: UBERON:0010536 name: nephron progenitor is_a: UBERON:0000479 {source="ZFA"} ! tissue relationship: BFO:0000050 UBERON:0003918 {source="cjm"} ! part of kidney mesenchyme relationship: RO:0002387 UBERON:0001285 ! has potential to develop into nephron [Term] id: UBERON:0010537 name: mesonephric nephron progenitor def: "Cluster of cells comprising a portion of tissue which gives rise to new mesonephric nephrons. The cluster contains self-renewing stem cells." [ZFA:0005587] xref: ZFA:0005587 is_a: UBERON:0010536 ! nephron progenitor intersection_of: UBERON:0010536 ! nephron progenitor intersection_of: BFO:0000050 UBERON:0000080 ! part of mesonephros relationship: BFO:0000050 UBERON:0000080 ! part of mesonephros [Term] id: UBERON:0010538 name: paired limb/fin segment def: "An appendage segment that is part of a limb/fin." [OBOL:automatic] subset: homology_grouping synonym: "limb/fin segment" EXACT [] is_a: UBERON:0010758 ! subdivision of organism along appendicular axis intersection_of: UBERON:0010758 ! subdivision of organism along appendicular axis intersection_of: BFO:0000050 UBERON:0004708 ! part of paired limb/fin disjoint_from: UBERON:0010912 ! subdivision of skeleton relationship: BFO:0000050 UBERON:0004708 ! part of paired limb/fin [Term] id: UBERON:0010540 name: tarsus pre-cartilage condensation def: "A pre-cartilage condensation that has the potential to develop into a tarsal bone." [OBOL:automatic] xref: EHDAA2:0001978 is_a: UBERON:0003328 ! mesenchyme of footplate is_a: UBERON:0005866 ! pre-cartilage condensation is_a: UBERON:0010695 ! mesenchyme of tarsal region is_a: UBERON:0015050 ! tarsus endochondral element intersection_of: UBERON:0005866 ! pre-cartilage condensation intersection_of: RO:0002387 UBERON:0001447 ! has potential to develop into tarsal bone relationship: BFO:0000050 UBERON:0003328 ! part of mesenchyme of footplate relationship: RO:0002202 UBERON:0010695 ! develops from mesenchyme of tarsal region relationship: RO:0002387 UBERON:0001447 ! has potential to develop into tarsal bone [Term] id: UBERON:0010541 name: tarsus cartilage element def: "A cartilaginous condensation that has the potential to develop into a tarsal bone." [OBOL:automatic] xref: EHDAA2:0001977 is_a: UBERON:0003328 ! mesenchyme of footplate is_a: UBERON:0005863 ! cartilaginous condensation is_a: UBERON:0010695 ! mesenchyme of tarsal region is_a: UBERON:0015050 ! tarsus endochondral element intersection_of: UBERON:0005863 ! cartilaginous condensation intersection_of: RO:0002387 UBERON:0001447 ! has potential to develop into tarsal bone relationship: BFO:0000050 UBERON:0003328 {source="EHDAA2"} ! part of mesenchyme of footplate relationship: RO:0002202 UBERON:0010540 {source="EHDAA2"} ! develops from tarsus pre-cartilage condensation relationship: RO:0002387 UBERON:0001447 ! has potential to develop into tarsal bone [Term] id: UBERON:0010543 name: acropodial skeleton def: "The subdivision of the skeleton that consists of all the skeletal elements at the distalmost end of the autopodium - i.e. the bones of the digits or their cartilaginous precursors[VSAO,modified]." [https://orcid.org/0000-0002-6601-2165, VSAO:0005028, VSAO:NI] synonym: "acropodial skeleton" EXACT [] synonym: "acropodium" RELATED [VSAO:0005028, VSAO:NI] synonym: "acropodium skeleton" EXACT [] synonym: "digital skeleton" RELATED [] synonym: "digits skeleton" RELATED [] synonym: "phalangeal skeleton" RELATED [] synonym: "set of phalanges" EXACT [FMA:231315] synonym: "skeletal parts of acropodial region" EXACT [] synonym: "skeletal parts of acropodium" RELATED [] synonym: "skeleton of digits" RELATED [] xref: FMA:231315 xref: VSAO:0005028 is_a: BFO:0000002 is_a: UBERON:0010712 ! limb skeleton subdivision intersection_of: UBERON:0010912 ! subdivision of skeleton intersection_of: RO:0002576 UBERON:0012354 ! skeleton of acropodium region relationship: BFO:0000050 UBERON:0012150 {source="PHENOSCAPE:ni"} ! part of skeleton of digitopodium relationship: BFO:0000051 UBERON:0015023 ! has part phalanx endochondral element relationship: proximally_connected_to UBERON:0010546 ! metapodial skeleton relationship: RO:0002576 UBERON:0012354 ! skeleton of acropodium region [Term] id: UBERON:0010544 name: metacarpus skeleton def: "The metacarpus is the intermediate part of the manus skeleton that is located between the phalanges (bones of the fingers) distally and the carpus which forms the connection to the forearm. The metacarpus consists of metacarpal bones. The metacarpals form a transverse arch to which the rigid row of distal carpal bones are fixed. The peripheral metacarpals (those of the thumb and little finger) form the sides of the cup of the palmar gutter and as they are brought together they deepen this concavity. The index metacarpal is the most firmly fixed, while the thumb metacarpal articulates with the trapezium and acts independently from the others. The middle metacarpals are tightly united to the carpus by intrinsic interlocking bone elements at their bases. The ring metacarpal forms a transitional element of the semi-independent last metacarpal. [WP,unvetted]." [Wikipedia:Metacarpus] synonym: "anterior metapodial skeleton" EXACT [] synonym: "anterior metapodium" RELATED [VSAO:0005026, VSAO:NI] synonym: "fore metapodial skeleton" RELATED [] synonym: "fore metapodium" RELATED [AAO:0000946, http://en.wiktionary.org/wiki/metapodial, MA:th] synonym: "metacarpal bones" EXACT [FMA:71336] synonym: "metacarpal skeleton" EXACT [] synonym: "metacarpalia" RELATED OMO:0003011 [Wikipedia:Metacarpus] synonym: "metacarpals [I-V]" EXACT [FMA:71336] synonym: "metacarpals set" EXACT [FMA:71336] synonym: "ossa metacarpalia [I-V]" EXACT OMO:0003011 [FMA:71336, FMA:TA] synonym: "ossa metacarpi [I-V]" EXACT OMO:0003011 [FMA:71336, FMA:TA] synonym: "set of metacarpal bones" EXACT [FMA:71336] synonym: "set of metacarpals" EXACT [FMA:71336] synonym: "set of metacarpals [I-V]" EXACT [FMA:71336] synonym: "skeleton of metacarpus" EXACT [] xref: AAO:0000946 xref: FMA:71336 xref: MESH:D050279 xref: VSAO:0005026 xref: Wikipedia:Metacarpus xref: XAO:0003208 is_a: UBERON:0010546 ! metapodial skeleton is_a: UBERON:0015042 ! manual digit metacarpus endochondral element intersection_of: UBERON:0010912 ! subdivision of skeleton intersection_of: RO:0002576 UBERON:0004453 ! skeleton of metacarpus region disjoint_from: UBERON:0010545 {source="lexical"} ! metatarsus skeleton relationship: proximally_connected_to UBERON:0009880 ! carpal skeleton relationship: RO:0002202 UBERON:0010699 ! develops from manual digit metacarpus cartilage element relationship: RO:0002576 UBERON:0004453 ! skeleton of metacarpus region property_value: foaf:depiction "https://upload.wikimedia.org/wikipedia/commons/2/2f/Metacarpals_numbered-en.svg" xsd:anyURI [Term] id: UBERON:0010545 name: metatarsus skeleton def: "Limb segment that consists of the long bones of the pes. The metatarsals are analogous to the metacarpal bones of the manus." [Wikipedia:Metatarsus] synonym: "metatarsal bones set" EXACT [FMA:71340] synonym: "metatarsal skeleton" EXACT [] synonym: "metatarsalia" RELATED [] synonym: "metatarsals [I-V]" EXACT [FMA:71340] synonym: "ossa metatarsalia" RELATED OMO:0003011 [Wikipedia:Metatarsus] synonym: "ossa metatarsalia [I-V]" EXACT OMO:0003011 [FMA:71340, FMA:TA] synonym: "ossa metatarsi[I-V]" EXACT OMO:0003011 [FMA:71340, FMA:TA] synonym: "posterior metapodial skeleton" EXACT [] synonym: "posterior metapodium" RELATED [VSAO:0005027, VSAO:NI] synonym: "set of metatarsal bones" EXACT [FMA:71340] synonym: "set of metatarsals [I-V]" EXACT [FMA:71340] synonym: "skeleton of metatarsus" EXACT [] xref: AAO:0000221 xref: FMA:71340 xref: MESH:D008684 xref: VSAO:0005027 xref: Wikipedia:Metatarsus xref: XAO:0003212 is_a: UBERON:0010546 ! metapodial skeleton is_a: UBERON:0015036 ! pedal digit metatarsal endochondral element intersection_of: UBERON:0010912 ! subdivision of skeleton intersection_of: RO:0002576 UBERON:0000983 ! skeleton of metatarsus region relationship: proximally_connected_to UBERON:0009879 ! tarsal skeleton relationship: RO:0002202 UBERON:0010697 ! develops from pedal digit metatarsal cartilage element relationship: RO:0002576 UBERON:0000983 ! skeleton of metatarsus region property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/5/52/Gray291.png" xsd:anyURI [Term] id: UBERON:0010546 name: metapodial skeleton def: "Subdivision of skeleton that corresponds to metapodium region, between acropodial skeleton and mesopdoial skeleton." [https://orcid.org/0000-0002-6601-2165] synonym: "metacarpal/metatarsal skeleton" EXACT [] synonym: "metapodial skeleton" EXACT [VSAO:0005025] synonym: "metapodium" RELATED [VSAO:0005025, VSAO:NI] synonym: "metapodium skeleton" EXACT [https://orcid.org/0000-0002-6601-2165] synonym: "skeletal parts of metapodium" EXACT [https://orcid.org/0000-0002-6601-2165] synonym: "skeleton of metapodium" EXACT [] xref: VSAO:0005025 is_a: UBERON:0010712 ! limb skeleton subdivision intersection_of: UBERON:0010912 ! subdivision of skeleton intersection_of: RO:0002576 UBERON:0009877 ! skeleton of metapodium region relationship: BFO:0000050 UBERON:0012150 {source="PHENOSCAPE:ni"} ! part of skeleton of digitopodium relationship: distally_connected_to UBERON:0010543 ! acropodial skeleton relationship: proximally_connected_to UBERON:0009878 ! mesopodial skeleton relationship: RO:0002576 UBERON:0009877 ! skeleton of metapodium region [Term] id: UBERON:0010585 name: pedal digit phalanx pre-cartilage condensation def: "A pre-cartilage condensation that is part of a pedal digit mesenchyme." [OBOL:automatic] synonym: "foot digit phalanx pre-cartilage condensation" NARROW SENSU [NCBITaxon:9606, OBOL:accepted] synonym: "foot phalanx pre-cartilage condensation" EXACT [VHOG:0000952] synonym: "hind limb digit phalanx pre-cartilage condensation" EXACT [OBOL:accepted] synonym: "hindlimb phalanx pre-cartilage condensation" EXACT [] synonym: "pes phalanx pre-cartilage condensation" EXACT [] xref: EMAPA:32950 xref: VHOG:0000952 is_a: UBERON:0010700 ! phalanx pre-cartilage condensation is_a: UBERON:0010886 ! hindlimb pre-cartilage condensation is_a: UBERON:0015030 ! pedal digit phalanx endochondral element intersection_of: UBERON:0015030 ! pedal digit phalanx endochondral element intersection_of: RO:0002473 UBERON:0005866 ! composed primarily of pre-cartilage condensation [Term] id: UBERON:0010586 name: manual digit phalanx pre-cartilage condensation def: "A pre-cartilage condensation that is part of a manual digit mesenchyme." [OBOL:automatic] synonym: "fore limb digit phalanx pre-cartilage condensation" EXACT [OBOL:accepted] synonym: "forelimb phalanx pre-cartilage condensation" EXACT [] synonym: "hand digit phalanx pre-cartilage condensation" NARROW SENSU [NCBITaxon:9606, OBOL:accepted] synonym: "hand phalanx pre-cartilage condensation" EXACT [VHOG:0000954] synonym: "manus phalanx pre-cartilage condensation" EXACT [] xref: EMAPA:32639 xref: VHOG:0000954 is_a: UBERON:0010700 ! phalanx pre-cartilage condensation is_a: UBERON:0010884 ! forelimb bone pre-cartilage condensation is_a: UBERON:0015024 ! manual digit phalanx endochondral element intersection_of: UBERON:0015024 ! manual digit phalanx endochondral element intersection_of: RO:0002473 UBERON:0005866 ! composed primarily of pre-cartilage condensation [Term] id: UBERON:0010685 name: pedal digit phalanx cartilage element def: "A cartilage element that is part of a pedal digit mesenchyme." [OBOL:automatic] synonym: "foot digit phalanx cartilage element" NARROW SENSU [NCBITaxon:9606, OBOL:accepted] synonym: "hind limb digit phalanx cartilage condensation" EXACT [OBOL:accepted] xref: EMAPA:32948 is_a: UBERON:0010701 ! phalanx cartilage element is_a: UBERON:0015030 ! pedal digit phalanx endochondral element is_a: UBERON:0035129 ! pes cartilage element intersection_of: UBERON:0015030 ! pedal digit phalanx endochondral element intersection_of: RO:0002473 UBERON:0002418 ! composed primarily of cartilage tissue relationship: RO:0002202 UBERON:0010585 ! develops from pedal digit phalanx pre-cartilage condensation [Term] id: UBERON:0010686 name: manual digit phalanx cartilage element def: "A cartilage element that is part of a manual digit mesenchyme." [OBOL:automatic] synonym: "fore limb digit phalanx cartilage condensation" EXACT [OBOL:accepted] synonym: "hand digit phalanx cartilage condensation" NARROW SENSU [NCBITaxon:9606, OBOL:accepted] xref: EMAPA:32658 is_a: UBERON:0010701 ! phalanx cartilage element is_a: UBERON:0015024 ! manual digit phalanx endochondral element is_a: UBERON:0035128 ! manus cartilage element intersection_of: UBERON:0015024 ! manual digit phalanx endochondral element intersection_of: RO:0002473 UBERON:0002418 ! composed primarily of cartilage tissue relationship: RO:0002202 UBERON:0010586 ! develops from manual digit phalanx pre-cartilage condensation [Term] id: UBERON:0010687 name: pedal digit metatarsal pre-cartilage condensation synonym: "foot digit metatarsal pre-cartilage condensation" NARROW SENSU [NCBITaxon:9606, OBOL:accepted] synonym: "hind limb digit metatarsal pre-cartilage condensation" EXACT [OBOL:accepted] synonym: "metatarsal bone pre-cartilage condensation" EXACT [] synonym: "metatarsal pre-cartilage condensation" RELATED [EMAPA:32956] synonym: "metatarsus pre-cartilage condensation" EXACT [VHOG:0000948] xref: EMAPA:32956 xref: EMAPA:35568 xref: VHOG:0000948 is_a: UBERON:0003860 ! hindlimb mesenchyme is_a: UBERON:0005866 ! pre-cartilage condensation is_a: UBERON:0010886 ! hindlimb pre-cartilage condensation is_a: UBERON:0015036 ! pedal digit metatarsal endochondral element intersection_of: UBERON:0015036 ! pedal digit metatarsal endochondral element intersection_of: RO:0002473 UBERON:0005866 ! composed primarily of pre-cartilage condensation [Term] id: UBERON:0010688 name: skeleton of manual acropodium def: "The subdivision of the skeleton that consists of all the skeletal elements at the distalmost end of the manual autopodium - i.e. the bones of the hands or their cartilaginous precursors[VSAO,modified]." [https://orcid.org/0000-0002-6601-2165, VSAO:0005029, VSAO:NI] synonym: "all phalanges in forelimb autopod" EXACT [] synonym: "anterior acropodium" RELATED [VSAO:0005029, VSAO:NI] synonym: "anterior acropodium skeleton" EXACT [] synonym: "fore acropodium skeleton" EXACT [] synonym: "hand digit skeleton" EXACT [] synonym: "manual digit skeleton" EXACT [] synonym: "manual phalanges" EXACT OMO:0003004 [VSAO:0005029, VSAO:NI] synonym: "phalanges of hand" EXACT [FMA:71337] synonym: "phalanges of manus" EXACT [] synonym: "set of manual phalanges" EXACT [] synonym: "set of phalanges of hand" EXACT [FMA:71337] synonym: "set of phalanges of manus" EXACT [] xref: FMA:71337 xref: VSAO:0005029 xref: Wikipedia:Phalanges_of_the_hand is_a: UBERON:0010543 ! acropodial skeleton intersection_of: UBERON:0010543 ! acropodial skeleton intersection_of: BFO:0000050 UBERON:0002398 ! part of manus disjoint_from: UBERON:0010696 {source="lexical"} ! skeleton of pedal acropodium relationship: BFO:0000050 UBERON:0012151 {source="PHENOSCAPE:ni"} ! part of skeleton of manual digitopodium relationship: proximally_connected_to UBERON:0010544 ! metacarpus skeleton [Term] id: UBERON:0010695 name: mesenchyme of tarsal region def: "Mesenchyme of the carpal region that contributes to the tarsal skeleton." [https://orcid.org/0000-0002-6601-2165] xref: EMAPA:18502 is_a: UBERON:0003860 ! hindlimb mesenchyme intersection_of: UBERON:0003104 ! mesenchyme intersection_of: BFO:0000050 UBERON:0004454 ! part of tarsal region relationship: BFO:0000050 UBERON:0004454 ! part of tarsal region [Term] id: UBERON:0010696 name: skeleton of pedal acropodium def: "The subdivision of the skeleton that consists of all the skeletal elements at the distalmost end of the pedal autopodium - i.e. the bones of the foot or their cartilaginous precursors[cjm]." [https://orcid.org/0000-0002-6601-2165] synonym: "all phalanges in hindlimb autopod" EXACT [] synonym: "foot digit skeleton" EXACT [] synonym: "hind acropodium skeleton" EXACT [] synonym: "pedal phalanges" EXACT [VSAO:0005030, VSAO:NI] synonym: "phalanges of foot" EXACT [FMA:78512] synonym: "phalanges of pes" EXACT [] synonym: "posterior acropodium" RELATED [VSAO:0005030, VSAO:NI] synonym: "posterior acropodium skeleton" EXACT [] synonym: "set of pedal phalanges" EXACT [] synonym: "set of phalanges of foot" EXACT [FMA:78512] synonym: "set of phalanges of pes" EXACT [] xref: FMA:78512 xref: VSAO:0005030 xref: Wikipedia:Phalanges_of_the_foot is_a: UBERON:0010543 ! acropodial skeleton intersection_of: UBERON:0010543 ! acropodial skeleton intersection_of: BFO:0000050 UBERON:0002387 ! part of pes relationship: BFO:0000050 UBERON:0012152 {source="PHENOSCAPE:ni"} ! part of skeleton of pedal digitopodium relationship: proximally_connected_to UBERON:0010545 ! metatarsus skeleton [Term] id: UBERON:0010697 name: pedal digit metatarsal cartilage element synonym: "foot digit metatarsal cartilage condensation" NARROW SENSU [NCBITaxon:9606, OBOL:accepted] synonym: "hind limb digit metatarsal cartilage condensation" EXACT [OBOL:accepted] synonym: "metatarsal cartilage condensation" RELATED [EMAPA:32951] xref: EMAPA:32951 is_a: UBERON:0015036 ! pedal digit metatarsal endochondral element is_a: UBERON:0035129 ! pes cartilage element intersection_of: UBERON:0015036 ! pedal digit metatarsal endochondral element intersection_of: RO:0002473 UBERON:0002418 ! composed primarily of cartilage tissue relationship: RO:0002202 UBERON:0010687 ! develops from pedal digit metatarsal pre-cartilage condensation property_value: IAO:0000116 "EMAPA represents the specific child classes as being part of the digit mesenchyme - we follow this although for the fully formed structure we represent the metatarsals as adjoining rather than being part of the digit skeleton" xsd:string [Term] id: UBERON:0010698 name: manual digit metacarpus pre-cartilage condensation synonym: "fore limb digit metacarpus pre-cartilage condensation" EXACT [OBOL:accepted] synonym: "hand digit metacarpus pre-cartilage condensation" NARROW SENSU [NCBITaxon:9606, OBOL:accepted] synonym: "metacarpal bone pre-cartilage condensation" EXACT [VHOG:0000953] synonym: "metacarpal pre-cartilage condensation" EXACT [] synonym: "metacarpus pre-cartilage condensation" EXACT [VHOG:0000953] xref: EMAPA:32850 xref: VHOG:0000953 is_a: UBERON:0010884 ! forelimb bone pre-cartilage condensation is_a: UBERON:0015042 ! manual digit metacarpus endochondral element intersection_of: UBERON:0015042 ! manual digit metacarpus endochondral element intersection_of: RO:0002473 UBERON:0005866 ! composed primarily of pre-cartilage condensation [Term] id: UBERON:0010699 name: manual digit metacarpus cartilage element synonym: "finger metacarpus cartilage element" EXACT [] synonym: "fore limb digit metacarpus cartilage element" EXACT [OBOL:accepted] synonym: "hand digit metacarpus cartilage element" NARROW SENSU [NCBITaxon:9606, OBOL:accepted] synonym: "metacarpal cartilage condensation" RELATED [EMAPA:32849] synonym: "metacarpal cartilage element" EXACT [] synonym: "metacarpus cartilage element" EXACT [] xref: EMAPA:32849 is_a: UBERON:0015042 ! manual digit metacarpus endochondral element is_a: UBERON:0035128 ! manus cartilage element intersection_of: UBERON:0015042 ! manual digit metacarpus endochondral element intersection_of: RO:0002473 UBERON:0002418 ! composed primarily of cartilage tissue relationship: RO:0002202 UBERON:0010698 ! develops from manual digit metacarpus pre-cartilage condensation [Term] id: UBERON:0010700 name: phalanx pre-cartilage condensation xref: EMAPA:32720 is_a: UBERON:0010882 ! limb bone pre-cartilage condensation is_a: UBERON:0015023 ! phalanx endochondral element intersection_of: UBERON:0015023 ! phalanx endochondral element intersection_of: RO:0002473 UBERON:0005866 ! composed primarily of pre-cartilage condensation relationship: BFO:0000050 UBERON:0010702 {source="EMAPA"} ! part of digit mesenchyme [Term] id: UBERON:0010701 name: phalanx cartilage element synonym: "phalanx cartilage condensation" EXACT [EMAPA:32721] xref: EMAPA:32721 is_a: UBERON:0015023 ! phalanx endochondral element is_a: UBERON:0015064 ! autopod cartilage intersection_of: UBERON:0015023 ! phalanx endochondral element intersection_of: RO:0002473 UBERON:0002418 ! composed primarily of cartilage tissue relationship: RO:0002202 UBERON:0010700 ! develops from phalanx pre-cartilage condensation [Term] id: UBERON:0010702 name: digit mesenchyme def: "Mesenchyme of the digit region." [http://orcid.org/0000-0002-6601-2165] synonym: "digital ray" RELATED [NCIT:C34141] xref: EMAPA:32719 xref: NCIT:C34141 xref: UMLS:C1511959 is_a: UBERON:0009749 ! limb mesenchyme intersection_of: UBERON:0003104 ! mesenchyme intersection_of: BFO:0000050 UBERON:0002544 ! part of digit relationship: BFO:0000050 UBERON:0002544 ! part of digit [Term] id: UBERON:0010703 name: forelimb zeugopod skeleton def: "The collection of all skeletal elements in an forelimb zeugopod region." [https://orcid.org/0000-0002-6601-2165] synonym: "antebrachial skeleton" EXACT [] synonym: "antebrachium skeleton" EXACT [PHENOSCAPE:ni] synonym: "anterior zeugopodium" RELATED [VSAO:0005011, VSAO:NI] synonym: "anterior zeugopodium skeleton" EXACT [VSAO:0005011, VSAO:NI] synonym: "fore epipodium" RELATED [AAO:0000200] synonym: "fore epipodium skeleton" EXACT [] synonym: "forearm skeleton" EXACT [FMA:71199] synonym: "forelimb epipodium" RELATED [VSAO:0005011, VSAO:NI] synonym: "forelimb epipodium skeleton" RELATED [] synonym: "mesomere 2 of pectoral appendage" RELATED HOMOLOGY [ISBN:0226313409] synonym: "radius and ulna" RELATED [] synonym: "skeleton of forearm" EXACT HUMAN_PREFERRED [FMA:71199] synonym: "wing zeugopod skeleton" NARROW SENSU [NCBITaxon:8782, OBOL:automatic] xref: AAO:0000200 xref: FMA:71199 xref: VSAO:0005011 is_a: UBERON:0011584 ! zeugopodial skeleton intersection_of: UBERON:0010912 ! subdivision of skeleton intersection_of: RO:0002576 UBERON:0002386 ! skeleton of forelimb zeugopod disjoint_from: UBERON:0010720 {source="lexical"} ! hindlimb zeugopod skeleton relationship: BFO:0000050 UBERON:0001440 ! part of forelimb skeleton relationship: RO:0002576 UBERON:0002386 ! skeleton of forelimb zeugopod property_value: IAO:0000116 "adding proxinally_connected_to humerus causes inconsistencies - requires investigation" xsd:string [Term] id: UBERON:0010707 name: appendage girdle complex def: "An organism subdivision that includes both an appendage and its associated girdle region. Note that this includes both the skeletal elements and associated tissues (integument, muscle, etc)." [https://github.com/obophenotype/uberon/wiki/Appendages-and-the-appendicular-skeleton, https://orcid.org/0000-0002-6601-2165] subset: pheno_slim synonym: "appendage complex" EXACT [https://orcid.org/0000-0002-6601-2165] synonym: "appendage-girdle complex" EXACT [https://orcid.org/0000-0002-6601-2165] synonym: "appendage/girdle complex" EXACT [VSAO:0000214] synonym: "girdle plus limb or fin" EXACT [https://orcid.org/0000-0002-6601-2165] synonym: "limb" RELATED INCONSISTENT [FMA:7182] xref: EMAPA:37858 {source="MA:th"} xref: FMA:7182 xref: VSAO:0000214 is_a: UBERON:0000475 ! organism subdivision is_a: UBERON:0015212 ! lateral structure relationship: BSPO:0000126 UBERON:0000468 ! multicellular organism relationship: RO:0002162 NCBITaxon:7742 ! in taxon Vertebrata relationship: RO:0002328 GO:0040011 ! functionally related to locomotion property_value: IAO:0000116 "It is still called a complex when one of the two parts is missing (?) There are fossil fishes with only an outgrowth (no record of a girdle), including thelodonts (which have a suprabranchial fin) as well as some anaspids which have a distinctive 'paired fin' (with differing published assertions on whether it's homologous to a pec fin or pelvic fin or both or neither). There are many fishes and other vertebrates with only a girdle and no outgrowth.[VSAO]" xsd:string property_value: skos:prefLabel "appendage girdle complex" xsd:string property_value: terms:contributor https://orcid.org/0000-0001-9114-8737 creation_date: 2012-04-23T10:46:51Z [Term] id: UBERON:0010708 name: pectoral complex def: "Appendage girdle complex that when present, encompasses the pectoral appendicular skeleton and the pectoral girdle." [VSAO:0000213] subset: pheno_slim synonym: "pectoral appendage/girdle complex" EXACT [VSAO:0000213] synonym: "pectoral girdle plus anterior limb or fin" EXACT [https://orcid.org/0000-0002-6601-2165] synonym: "pectoral girdle plus pectoral limb or fin" EXACT [https://orcid.org/0000-0002-6601-2165] synonym: "upper limb" RELATED INCONSISTENT [FMA:7183] synonym: "upper limb and pectoral girdle" RELATED HUMAN_PREFERRED [https://orcid.org/0000-0002-6601-2165] synonym: "upper limb and shoulder" RELATED [https://orcid.org/0000-0002-6601-2165] xref: EMAPA:37860 {source="MA:th"} xref: FMA:7183 xref: SCTID:110716002 xref: VSAO:0000213 is_a: UBERON:0010707 ! appendage girdle complex intersection_of: UBERON:0010707 ! appendage girdle complex intersection_of: BFO:0000051 UBERON:0001421 ! has part pectoral girdle region relationship: BFO:0000051 UBERON:0001421 ! has part pectoral girdle region relationship: RO:0002551 UBERON:0012475 ! has skeleton skeleton of pectoral complex property_value: skos:prefLabel "pectoral complex" xsd:string [Term] id: UBERON:0010709 name: pelvic complex def: "Appendage girdle complex that when present, encompasses the pelvic appendicular skeleton and the pelvic girdle." [VSAO:0000215] subset: pheno_slim synonym: "lower limb" RELATED INCONSISTENT [FMA:7184] synonym: "lower limb and pelvic girdle" RELATED HUMAN_PREFERRED [https://orcid.org/0000-0002-6601-2165] synonym: "lower limb and pelvis" RELATED [https://orcid.org/0000-0002-6601-2165] synonym: "pelvic appendage/girdle complex" EXACT [VSAO:0000215] synonym: "pelvic girdle plus pelvic limb or fin" EXACT [https://orcid.org/0000-0002-6601-2165] synonym: "pelvic girdle plus posterior limb or fin" EXACT [https://orcid.org/0000-0002-6601-2165] xref: EMAPA:37863 {source="MA:th"} xref: FMA:7184 xref: SCTID:416631005 xref: VSAO:0000215 is_a: BFO:0000002 is_a: UBERON:0010707 ! appendage girdle complex intersection_of: UBERON:0010707 ! appendage girdle complex intersection_of: BFO:0000051 UBERON:0001271 ! has part pelvic girdle region relationship: BFO:0000051 UBERON:0001271 ! has part pelvic girdle region relationship: RO:0002551 UBERON:0012476 ! has skeleton skeleton of pelvic complex [Term] id: UBERON:0010712 name: limb skeleton subdivision def: "Skeletal subdivision that is a segment of the limb skeleton." [VSAO:0005018, VSAO:NI] xref: VSAO:0005018 is_a: UBERON:0010912 ! subdivision of skeleton intersection_of: UBERON:0010912 ! subdivision of skeleton intersection_of: BFO:0000050 UBERON:0002101 ! part of limb relationship: BFO:0000050 UBERON:0002091 {source="VSAO"} ! part of appendicular skeleton relationship: BFO:0000050 UBERON:0002101 ! part of limb property_value: IAO:0000116 "note the distinction between this and skeleton of limb" xsd:string [Term] id: UBERON:0010714 name: iliac cartilage element def: "An iliac endochondral element that is composed primarily of cartilage tissue." [OBOL:automatic] synonym: "iliac cartilage condensation" RELATED [EMAPA:18347] xref: EHDAA2:0000808 xref: EMAPA:18347 xref: VHOG:0001126 is_a: UBERON:0005863 {source="EHDAA2"} ! cartilaginous condensation is_a: UBERON:0007844 ! cartilage element is_a: UBERON:0015054 ! iliac endochondral element intersection_of: UBERON:0015054 ! iliac endochondral element intersection_of: RO:0002473 UBERON:0002418 ! composed primarily of cartilage tissue relationship: RO:0002202 UBERON:0006247 {source="EHDAA2"} ! develops from iliac pre-cartilage condensation [Term] id: UBERON:0010719 name: girdle skeleton def: "The subdivision of the skeleton of either the pectoral or pelvic girdle." [https://orcid.org/0000-0002-6601-2165] synonym: "skeleton of girdle" EXACT [] xref: AAO:0010686 xref: VSAO:0000302 is_a: UBERON:0010912 ! subdivision of skeleton intersection_of: UBERON:0010912 ! subdivision of skeleton intersection_of: RO:0002576 UBERON:0007823 ! skeleton of appendage girdle region relationship: BFO:0000050 UBERON:0002091 ! part of appendicular skeleton relationship: proximally_connected_to UBERON:0002090 ! postcranial axial skeleton relationship: RO:0002576 UBERON:0007823 ! skeleton of appendage girdle region property_value: skos:prefLabel "girdle skeleton" xsd:string [Term] id: UBERON:0010720 name: hindlimb zeugopod skeleton def: "Subdivision of skeleton consisting of all skeletal elements in an hindlimb zeugopod region. Typically consists of the tibia and the fibula." [https://orcid.org/0000-0002-6601-2165] synonym: "crural skeleton" EXACT [http://orcid.org/0000-0002-6601-2165] synonym: "crus skeleton" EXACT [PHENOSCAPE:ni] synonym: "hind epipodium" RELATED [AAO:0000216] synonym: "hindlimb epipodium" RELATED [VSAO:0005014, VSAO:NI] synonym: "hindlimb zygopod skeleton" EXACT [] synonym: "mesomere 2 of pelvic appendage" RELATED HOMOLOGY [ISBN:0226313409] synonym: "posterior zeugopodium" RELATED INCONSISTENT [VSAO:0005014] synonym: "posterior zeugopodium skeleton" EXACT [] synonym: "skeleton cruris" EXACT OMO:0003011 [NominaAnatomicaVeterinaria:2005] xref: AAO:0000216 xref: VSAO:0005014 is_a: UBERON:0011584 ! zeugopodial skeleton intersection_of: UBERON:0010912 ! subdivision of skeleton intersection_of: RO:0002576 UBERON:0003823 ! skeleton of hindlimb zeugopod relationship: proximally_connected_to UBERON:0000981 ! femur relationship: RO:0002576 UBERON:0003823 ! skeleton of hindlimb zeugopod [Term] id: UBERON:0010728 name: sphenoid lesser wing pre-cartilage condensation def: "An orbitosphenoid endochondral element that is composed primarily of a pre-cartilage condensation." [OBOL:automatic] xref: EHDAA2:0003449 is_a: UBERON:0005866 {source="EHDAA2"} ! pre-cartilage condensation is_a: UBERON:0006904 ! head mesenchyme from mesoderm is_a: UBERON:0009891 ! facial mesenchyme is_a: UBERON:0015059 ! orbitosphenoid endochondral element intersection_of: UBERON:0015059 ! orbitosphenoid endochondral element intersection_of: RO:0002473 UBERON:0005866 ! composed primarily of pre-cartilage condensation relationship: BFO:0000050 UBERON:0009191 {source="EHDAA2"} ! part of sphenoid bone pre-cartilage condensation relationship: RO:0002202 UBERON:0006904 {source="EHDAA2"} ! develops from head mesenchyme from mesoderm relationship: RO:0002473 UBERON:0005866 ! composed primarily of pre-cartilage condensation property_value: skos:prefLabel "sphenoid lesser wing pre-cartilage condensation" xsd:string [Term] id: UBERON:0010740 name: bone of appendage girdle complex def: "A bone that is part of an appendage girdle complex (i.e. any bone in a limb, fin or girdle)." [https://orcid.org/0000-0002-6601-2165, UBERONREF:0000003] subset: pheno_slim synonym: "bone of extended limb/fin region" RELATED [https://orcid.org/0000-0002-6601-2165, UBERONREF:0000003] synonym: "limb bone" RELATED [MA:0000688, UBERONREF:0000003] xref: EMAPA:35494 xref: MA:0000688 is_a: UBERON:0001474 ! bone element intersection_of: UBERON:0001474 ! bone element intersection_of: BFO:0000050 UBERON:0010707 ! part of appendage girdle complex relationship: BFO:0000050 UBERON:0002091 ! part of appendicular skeleton relationship: BFO:0000050 UBERON:0010707 ! part of appendage girdle complex relationship: RO:0002433 UBERON:0002091 ! contributes to morphology of appendicular skeleton property_value: skos:prefLabel "bone of appendage girdle complex" xsd:string [Term] id: UBERON:0010741 name: bone of pectoral complex def: "A bone that is part of a pectoral complex. Examples: scapula, manus phalanx, any carpal bone, any bone of the pectoral fin." [https://orcid.org/0000-0002-6601-2165, UBERONREF:0000003] subset: pheno_slim synonym: "bone of forelimb or pectoral fin or pectoral girdle" RELATED [https://orcid.org/0000-0002-6601-2165, UBERONREF:0000003] synonym: "forelimb bone" RELATED [MA:0000612, UBERONREF:0000003] synonym: "wing bone" NARROW SENSU [UBERONREF:0000003] xref: EMAPA:35933 xref: MA:0000612 is_a: UBERON:0010740 ! bone of appendage girdle complex intersection_of: UBERON:0001474 ! bone element intersection_of: BFO:0000050 UBERON:0010708 ! part of pectoral complex relationship: BFO:0000050 UBERON:0010708 ! part of pectoral complex property_value: IAO:0000116 "considering adding pectoral and pelvic complex skeleton classes" xsd:string property_value: skos:prefLabel "bone of pectoral complex" xsd:string [Term] id: UBERON:0010742 name: bone of pelvic complex def: "A bone that is part of a pelvic complex. Examples: pubis, ischium, fot phalanx, any tarsal bone, any bone of the pelvic fin or girdle." [https://orcid.org/0000-0002-6601-2165, UBERONREF:0000003] subset: pheno_slim synonym: "hindlimb bone" RELATED [MA:0000660, UBERONREF:0000003] xref: EMAPA:35934 xref: MA:0000660 is_a: UBERON:0010740 {source="MA"} ! bone of appendage girdle complex intersection_of: UBERON:0001474 ! bone element intersection_of: BFO:0000050 UBERON:0010709 ! part of pelvic complex relationship: BFO:0000050 UBERON:0010709 ! part of pelvic complex [Term] id: UBERON:0010743 name: meningeal cluster def: "The collection of all meningeal layers that line a central nervous system." [https://orcid.org/0000-0002-6601-2165] subset: pheno_slim synonym: "cerebral meninges" EXACT [] synonym: "cluster of meninges" EXACT [FMA:231572] synonym: "meninges" EXACT [FMA:231572] xref: EHDAA2:0004661 xref: FMA:231572 xref: NCIT:C12349 xref: neuronames:1465 xref: SCTID:362879001 xref: UMLS:C0228116 xref: Wikipedia:Meninges is_a: BFO:0000002 is_a: BFO:0000004 is_a: UBERON:0034925 ! anatomical collection intersection_of: UBERON:0034925 ! anatomical collection intersection_of: RO:0002007 UBERON:0001017 ! bounding layer of central nervous system intersection_of: RO:0002351 UBERON:0002360 ! has member meninx relationship: RO:0002007 UBERON:0001017 ! bounding layer of central nervous system relationship: RO:0002351 UBERON:0002360 ! has member meninx property_value: skos:prefLabel "meningeal cluster" xsd:string [Term] id: UBERON:0010744 name: sacral vertebra pre-cartilage condensation def: "A sacral vertebra endochondral element that is composed primarily of a pre-cartilage condensation." [OBOL:automatic] synonym: "sacral vertebral pre-cartilage condensation group" EXACT [EHDAA2:0001774] xref: EHDAA2:0001774 xref: EMAPA:17677 is_a: UBERON:0011095 ! vertebra pre-cartilage condensation is_a: UBERON:0015010 ! sacral vertebra endochondral element intersection_of: UBERON:0015010 ! sacral vertebra endochondral element intersection_of: RO:0002473 UBERON:0005866 ! composed primarily of pre-cartilage condensation [Term] id: UBERON:0010745 name: sacral vertebra cartilage element def: "A sacral vertebra endochondral element that is composed primarily of cartilage tissue." [OBOL:automatic] synonym: "sacral vertebral cartilage condensation" EXACT [] synonym: "sacral vertebral cartilage condensation group" EXACT [EHDAA2:0001773] xref: EHDAA2:0001773 xref: EMAPA:18009 is_a: UBERON:0011094 ! vertebra cartilage element is_a: UBERON:0015010 ! sacral vertebra endochondral element is_a: UBERON:2001457 ! postcranial axial cartilage intersection_of: UBERON:0015010 ! sacral vertebra endochondral element intersection_of: RO:0002473 UBERON:0002418 ! composed primarily of cartilage tissue relationship: RO:0002202 UBERON:0010744 {source="EHDAA2"} ! develops from sacral vertebra pre-cartilage condensation [Term] id: UBERON:0010748 name: lymph node follicle def: "A lymphoid follicle that is part of a lymph node." [OBOL:automatic] synonym: "follicle of lymph node" EXACT [] xref: EMAPA:35527 xref: MA:0000742 is_a: UBERON:0000444 ! lymphoid follicle intersection_of: UBERON:0000444 ! lymphoid follicle intersection_of: BFO:0000050 UBERON:0000029 ! part of lymph node relationship: BFO:0000050 UBERON:0002006 ! part of cortex of lymph node property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/lymph-node-female/v1.4/assets/3d-nih-f-lymph-node.glb" xsd:anyURI property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/lymph-node-male/v1.4/assets/3d-nih-m-lymph-node.glb" xsd:anyURI [Term] id: UBERON:0010753 name: lymph node secondary follicle def: "A secondary follicle that is located in a lymph node." [CL:tm] subset: human_reference_atlas subset: pheno_slim xref: EMAPA:35531 xref: FMA:312352 xref: MA:0000744 is_a: UBERON:0001745 ! secondary nodular lymphoid tissue is_a: UBERON:0010748 {source="MA"} ! lymph node follicle intersection_of: UBERON:0001745 ! secondary nodular lymphoid tissue intersection_of: BFO:0000050 UBERON:0000029 ! part of lymph node relationship: RO:0002202 UBERON:0010395 ! develops from lymph node primary follicle property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0010754 name: germinal center def: "A collection of activated B cells at the center of a secondary follicle, formed after B cells become activated and migrate to the center." [CL:tm, https://orcid.org/0000-0002-6601-2165, Wikipedia:Germinal_center] comment: A germinal center is a specialized microenvironment formed when activated B cells enter lymphoid follicles. Germinal centers are the foci for B cell proliferation and somatic hypermutation.[GO] subset: human_reference_atlas synonym: "central zone of follice" EXACT [CL:tm] synonym: "light zone of follicle" NARROW [CL:tm] synonym: "lymhpoid nodule" RELATED [CL:tm] synonym: "nodule" RELATED [CL:tm] synonym: "reaction center of follicle" EXACT [CL:tm] xref: BTO:0003671 xref: EV:0100051 xref: MESH:D018858 xref: NCIT:C13337 xref: UMLS:C0282491 {source="ncithesaurus:Germinal_Center"} xref: Wikipedia:Germinal_center is_a: UBERON:0001744 ! lymphoid tissue relationship: BFO:0000050 UBERON:0001745 ! part of secondary nodular lymphoid tissue property_value: foaf:depiction "https://upload.wikimedia.org/wikipedia/commons/6/60/Germinal_center.svg" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0010755 name: secondary follicle corona def: "The part of the secondary follicle that surrounds the germinal center." [CL:tm, https://orcid.org/0000-0002-6601-2165] synonym: "B cell corona" RELATED [] synonym: "dark zone of follicle" RELATED [CL:tm] synonym: "inactive zone of follicle" EXACT [CL:tm] synonym: "mantle zone" RELATED [] synonym: "peripheral zone of follicle" EXACT [CL:tm] xref: NCIT:C33053 xref: UMLS:C1512987 {source="ncithesaurus:Mantle_Zone"} xref: Wikipedia:Mantle_zone is_a: UBERON:0001744 ! lymphoid tissue intersection_of: UBERON:0001744 ! lymphoid tissue intersection_of: BFO:0000050 UBERON:0001745 ! part of secondary nodular lymphoid tissue intersection_of: RO:0002221 UBERON:0010754 ! surrounds germinal center relationship: BFO:0000050 UBERON:0001745 ! part of secondary nodular lymphoid tissue relationship: RO:0002221 UBERON:0010754 ! surrounds germinal center property_value: IAO:0000116 "consider making terminology consistent amongst subclasses - see https://github.com/obophenotype/uberon/issues/7" xsd:string [Term] id: UBERON:0010758 name: subdivision of organism along appendicular axis def: "A major subdivision of an organism that divides an organism along an axis perpedicular to the main body anterior-posterior axis. In vertebrates, this is typically a fin or limb segment. In insects, this includes segments of appendages such as antennae, as well as segments of the insect leg." [https://orcid.org/0000-0002-6601-2165] subset: upper_level synonym: "appendage segment" EXACT [FBbt:00007018] synonym: "appendicular segment" EXACT [] xref: FBbt:00007018 {sssom:mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"} is_a: UBERON:0000475 ! organism subdivision relationship: BFO:0000050 UBERON:0000026 ! part of appendage [Term] id: UBERON:0010843 name: clavicle cartilage element def: "A cartilaginous condensation that has the potential to develop into a clavicle." [OBOL:automatic] xref: EMAPA:18342 is_a: UBERON:0005863 ! cartilaginous condensation intersection_of: UBERON:0005863 ! cartilaginous condensation intersection_of: RO:0002387 UBERON:0001105 ! has potential to develop into clavicle bone relationship: BFO:0000050 UBERON:0007831 ! part of pectoral girdle skeleton relationship: RO:0002202 UBERON:0010844 ! develops from clavicle pre-cartilage condensation relationship: RO:0002387 UBERON:0001105 ! has potential to develop into clavicle bone [Term] id: UBERON:0010844 name: clavicle pre-cartilage condensation def: "A pre-cartilage condensation that has the potential to develop into a clavicle." [OBOL:automatic] xref: EMAPA:18026 is_a: UBERON:0005866 ! pre-cartilage condensation intersection_of: UBERON:0005866 ! pre-cartilage condensation intersection_of: RO:0002387 UBERON:0001105 ! has potential to develop into clavicle bone relationship: BFO:0000050 UBERON:0007831 ! part of pectoral girdle skeleton relationship: RO:0002387 UBERON:0001105 ! has potential to develop into clavicle bone [Term] id: UBERON:0010849 name: tibia cartilage element def: "A cartilaginous condensation that has the potential to develop into a tibia." [OBOL:automatic] xref: EMAPA:18155 is_a: UBERON:0010885 ! hindlimb cartilage element is_a: UBERON:0015004 ! tibia endochondral element intersection_of: UBERON:0015004 ! tibia endochondral element intersection_of: RO:0002473 UBERON:0002418 ! composed primarily of cartilage tissue relationship: BFO:0000050 UBERON:0005259 {source="EMAPA"} ! part of lower leg mesenchyme relationship: RO:0002202 UBERON:0010850 ! develops from tibia pre-cartilage condensation [Term] id: UBERON:0010850 name: tibia pre-cartilage condensation def: "A pre-cartilage condensation that has the potential to develop into a tibia." [OBOL:automatic] xref: EHDAA2:0002036 is_a: UBERON:0005259 ! lower leg mesenchyme is_a: UBERON:0005866 ! pre-cartilage condensation is_a: UBERON:0015004 ! tibia endochondral element intersection_of: UBERON:0005866 ! pre-cartilage condensation intersection_of: RO:0002387 UBERON:0000979 ! has potential to develop into tibia relationship: BFO:0000050 UBERON:0005259 {source="EHDAA2"} ! part of lower leg mesenchyme relationship: RO:0002387 UBERON:0000979 ! has potential to develop into tibia [Term] id: UBERON:0010851 name: fibula cartilage element def: "A cartilaginous condensation that has the potential to develop into a fibula." [OBOL:automatic] synonym: "fibulal cartilage condensation" EXACT [EMAPA:18154] synonym: "fibular cartilage condensation" EXACT [EMAPA:18154] synonym: "fibulra cartilage condensation" RELATED [EMAPA:18154] xref: EMAPA:18154 is_a: UBERON:0010885 ! hindlimb cartilage element is_a: UBERON:0015013 ! fibula endochondral element intersection_of: UBERON:0015013 ! fibula endochondral element intersection_of: RO:0002473 UBERON:0002418 ! composed primarily of cartilage tissue relationship: BFO:0000050 UBERON:0005259 {source="EMAPA"} ! part of lower leg mesenchyme relationship: RO:0002202 UBERON:0010852 ! develops from fibula pre-cartilage condensation [Term] id: UBERON:0010852 name: fibula pre-cartilage condensation def: "A pre-cartilage condensation that has the potential to develop into a fibula." [OBOL:automatic] synonym: "fibulal pre-cartilage condensation" EXACT [] synonym: "fibular pre-cartilage condensation" EXACT [] xref: EHDAA2:0000509 xref: EHDAA:6196 is_a: UBERON:0005259 ! lower leg mesenchyme is_a: UBERON:0005866 ! pre-cartilage condensation is_a: UBERON:0015013 ! fibula endochondral element intersection_of: UBERON:0005866 ! pre-cartilage condensation intersection_of: RO:0002387 UBERON:0001446 ! has potential to develop into fibula relationship: BFO:0000050 UBERON:0005259 {source="EHDAA2"} ! part of lower leg mesenchyme relationship: RO:0002387 UBERON:0001446 ! has potential to develop into fibula [Term] id: UBERON:0010881 name: limb cartilage element def: "A skeletal element that is part of a limb and composed of cartilage tissue." [http://orcid.org/0000-0002-6601-2165] is_a: UBERON:0007844 ! cartilage element is_a: UBERON:0015061 ! limb endochondral element intersection_of: UBERON:0015061 ! limb endochondral element intersection_of: RO:0002473 UBERON:0002418 ! composed primarily of cartilage tissue relationship: RO:0002202 UBERON:0010882 ! develops from limb bone pre-cartilage condensation [Term] id: UBERON:0010882 name: limb bone pre-cartilage condensation def: "A skeletal element that is part of a limb and composed of pre-cartilage tissue." [http://orcid.org/0000-0002-6601-2165] is_a: UBERON:0015061 ! limb endochondral element intersection_of: UBERON:0015061 ! limb endochondral element intersection_of: RO:0002473 UBERON:0005866 ! composed primarily of pre-cartilage condensation relationship: RO:0002473 UBERON:0005866 ! composed primarily of pre-cartilage condensation [Term] id: UBERON:0010883 name: forelimb cartilage element def: "A cartilaginous condensation that has the potential to develop into a forelimb bone." [OBOL:automatic] subset: grouping_class synonym: "forelimb wing cartilaginous condensation" NARROW SENSU [NCBITaxon:8782, OBOL:automatic] synonym: "wing cartilaginous condensation" NARROW SENSU [NCBITaxon:8782, OBOL:automatic] xref: EMAPA:32626 is_a: UBERON:0010881 ! limb cartilage element is_a: UBERON:0015021 ! forelimb endochondral element intersection_of: UBERON:0015021 ! forelimb endochondral element intersection_of: RO:0002473 UBERON:0002418 ! composed primarily of cartilage tissue relationship: RO:0002202 UBERON:0010884 ! develops from forelimb bone pre-cartilage condensation [Term] id: UBERON:0010884 name: forelimb bone pre-cartilage condensation def: "A pre-cartilage condensation that has the potential to develop into a forelimb bone." [OBOL:automatic] subset: grouping_class synonym: "wing bone pre-cartilage condensation" NARROW SENSU [NCBITaxon:8782, OBOL:automatic] xref: EMAPA:32625 is_a: UBERON:0010882 ! limb bone pre-cartilage condensation is_a: UBERON:0015021 ! forelimb endochondral element intersection_of: UBERON:0015021 ! forelimb endochondral element intersection_of: RO:0002473 UBERON:0005866 ! composed primarily of pre-cartilage condensation [Term] id: UBERON:0010885 name: hindlimb cartilage element def: "A cartilaginous condensation that has the potential to develop into a hindlimb bone." [OBOL:automatic] synonym: "hindlimb cartilage condensation" EXACT [EMAPA:32632] xref: EMAPA:32632 is_a: UBERON:0010881 ! limb cartilage element is_a: UBERON:0015022 ! hindlimb endochondral element intersection_of: UBERON:0015022 ! hindlimb endochondral element intersection_of: RO:0002473 UBERON:0002418 ! composed primarily of cartilage tissue relationship: RO:0002202 UBERON:0010886 ! develops from hindlimb pre-cartilage condensation [Term] id: UBERON:0010886 name: hindlimb pre-cartilage condensation def: "A pre-cartilage condensation that has the potential to develop into a hindlimb bone." [OBOL:automatic] synonym: "hindlimb pre-cartilage condensation" EXACT [EMAPA:32638] xref: EMAPA:32638 is_a: UBERON:0010882 ! limb bone pre-cartilage condensation is_a: UBERON:0015022 ! hindlimb endochondral element intersection_of: UBERON:0015022 ! hindlimb endochondral element intersection_of: RO:0002473 UBERON:0005866 ! composed primarily of pre-cartilage condensation [Term] id: UBERON:0010890 name: pelvic complex muscle def: "Muscles of the pelvic girdle, hindlimb or pelvic fin." [https://orcid.org/0000-0002-6601-2165] subset: pheno_slim synonym: "lower limb muscle" RELATED INCONSISTENT [FMA:9622] synonym: "muscle of lower limb" RELATED INCONSISTENT [FMA:9622] synonym: "muscle of pelvic girdle and leg" RELATED [] synonym: "pelvic girdle and hind limb muscles" EXACT [AAO:0000218] synonym: "pelvic girdle or hind limb muscle" NARROW [https://orcid.org/0000-0002-6601-2165] synonym: "pelvic girdle or posterior limb muscle" NARROW [https://orcid.org/0000-0002-6601-2165] xref: AAO:0000218 xref: EMAPA:32634 xref: FMA:9622 xref: MA:0000663 is_a: UBERON:0014892 ! skeletal muscle organ, vertebrate intersection_of: UBERON:0014892 ! skeletal muscle organ, vertebrate intersection_of: BFO:0000050 UBERON:0010709 ! part of pelvic complex relationship: BFO:0000050 UBERON:0014792 {source="prolog"} ! part of musculature of pelvic complex [Term] id: UBERON:0010891 name: pectoral complex muscle def: "A muscle of a pectoral girdle, pectoral fin or anterior limb." [https://orcid.org/0000-0002-6601-2165] synonym: "muscle of pectoral girdle and limb" RELATED [] synonym: "muscle of pectoral girdle and wing" NARROW SENSU [NCBITaxon:8782] synonym: "muscle of upper limb" NARROW INCONSISTENT [FMA:9621] synonym: "pectoral girdle and fore limb muscles" EXACT [AAO:0010687] synonym: "upper limb muscle" NARROW INCONSISTENT [FMA:9621] xref: AAO:0010687 xref: EMAPA:32624 xref: FMA:9621 xref: MA:0000615 is_a: UBERON:0014892 ! skeletal muscle organ, vertebrate intersection_of: UBERON:0014892 ! skeletal muscle organ, vertebrate intersection_of: BFO:0000050 UBERON:0010708 ! part of pectoral complex relationship: BFO:0000050 UBERON:0014793 {source="prolog"} ! part of musculature of pectoral complex property_value: IAO:0000116 "the MA class belongs here, based on its current child classes" xsd:string property_value: skos:prefLabel "pectoral complex muscle" xsd:string [Term] id: UBERON:0010893 name: median external naris def: "Am unpaired external naris that lies in the midline of the head." [OBOL:automatic] subset: cyclostome_subset synonym: "median anterior naris" EXACT [] synonym: "median nostril" EXACT [] synonym: "nasohypophysial opening" EXACT [http://tolweb.org/Hyperoartia] is_a: UBERON:0005928 ! external naris intersection_of: UBERON:0005928 ! external naris intersection_of: BSPO:0005001 UBERON:0000033 ! head relationship: BSPO:0005001 UBERON:0000033 ! head property_value: RO:0002161 NCBITaxon:314146 property_value: RO:0002175 NCBITaxon:7762 [Term] id: UBERON:0010894 name: keratinous tooth comment: The hagfish's jawless mouth contains two parallel rows of pointed keratinous teeth subset: cyclostome_subset synonym: "horny denticle" EXACT [http://tolweb.org/Hyperoartia] is_a: UBERON:0003913 ! tooth-like structure intersection_of: UBERON:0003913 ! tooth-like structure intersection_of: RO:0002473 GO:0045095 ! composed primarily of keratin filament relationship: RO:0002162 NCBITaxon:7742 ! in taxon Vertebrata relationship: RO:0002473 GO:0045095 ! composed primarily of keratin filament property_value: RO:0002175 NCBITaxon:117569 property_value: RO:0002175 NCBITaxon:7762 [Term] id: UBERON:0010899 name: synchronous hermaphroditic organism def: "Hermaphroditic organism that produces both male and female gametes at the same time." [CARO:0000046] synonym: "serially hermaphroditic organism" RELATED [CARO:0000046] synonym: "simultaneous hermaphroditic organism" RELATED [https://orcid.org/0000-0002-6601-2165] xref: AAO:0010046 xref: BILA:0000046 xref: CARO:0000046 xref: HAO:0000046 xref: TADS:0000609 is_a: BFO:0000002 is_a: UBERON:0007197 {source="CARO"} ! hermaphroditic organism intersection_of: UBERON:0000468 ! multicellular organism intersection_of: BFO:0000051 UBERON:0000473 ! has part testis intersection_of: BFO:0000051 UBERON:0000992 ! has part ovary relationship: BFO:0000051 UBERON:0000473 ! has part testis relationship: BFO:0000051 UBERON:0000992 ! has part ovary [Term] id: UBERON:0010905 name: clavicle bone primordium def: "A primordium that develops into a clavicle bone." [https://github.com/obophenotype/uberon/issues/327] comment: lateral part derives from a fish dermal bone while the medial part comes from a spur off the manubrium endochondral bone[JB] synonym: "clavicle primordium" EXACT [] xref: EHDAA2:0000254 is_a: BFO:0000002 is_a: UBERON:0001048 ! primordium intersection_of: UBERON:0001048 ! primordium intersection_of: RO:0002387 UBERON:0001105 ! has potential to develop into clavicle bone relationship: BFO:0000050 UBERON:0007831 {source="EHDAA2"} ! part of pectoral girdle skeleton relationship: RO:0002202 UBERON:0006210 {source="EHDAA2"} ! develops from body-wall mesenchyme relationship: RO:0002254 UBERON:0002342 ! has developmental contribution from neural crest relationship: RO:0002387 UBERON:0001105 ! has potential to develop into clavicle bone [Term] id: UBERON:0010911 name: ossicle def: "Skeletal element that is often isolated, small, and variable in composition." [PSPUB:0000169, VSAO:0000132] comment: Ossicles are composed of a combination skeletal tissues, including bone, calcified cartilage, hyaline cartilage, etc, and exhibit variable development across species. Ossicles are not necessarily jointed, and examples include the menisci of synovial joints, 'Panda's thumb' (radial sesamoid), cardiac skeletal elements, sclerotic bones, middle ear ossicles, and sesamoids. subset: human_reference_atlas xref: VSAO:0000132 xref: Wikipedia:Ossicles is_a: UBERON:0004765 {source="VSAO"} ! skeletal element property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0010912 name: subdivision of skeleton def: "Anatomical cluster consisting of the skeletal elements (i.e. bone elements, cartilage elements, cartilage condensations) that are part of an individual subdivision of the organism. Excludes joints." [https://orcid.org/0000-0002-6601-2165, UBERONREF:0000003] subset: non_informative synonym: "skeletal subdivision" EXACT [VSAO:0000042] synonym: "subdivision of skeleton (in vivo)" RELATED [FMA:23879] xref: FMA:23879 xref: SCTID:129140006 xref: VSAO:0000042 is_a: UBERON:0011216 {source="cjm"} ! organ system subdivision relationship: BFO:0000050 UBERON:0000075 {source="UBERONREF:0000003"} ! part of subdivision of skeletal system relationship: BFO:0000050 UBERON:0004288 {source="VSAO"} ! part of skeleton property_value: skos:prefLabel "subdivision of skeleton" xsd:string [Term] id: UBERON:0010913 name: vertebral element def: "Skeletal element that forms around the notochord and is part of the vertebral column." [GO_REF:0000034, http://dx.plos.org/10.1371/journal.pone.0051070, https://github.com/obophenotype/uberon/issues/294, VSAO:0000184] synonym: "vertebra element" EXACT [https://github.com/obophenotype/uberon/wiki/Modeling-endochondral-elements-Design-Pattern] synonym: "vertebra endochondral element" NARROW [https://github.com/obophenotype/uberon/issues/82] synonym: "vertebra skeletal element" BROAD [https://github.com/obophenotype/uberon/wiki/Modeling-endochondral-elements-Design-Pattern] synonym: "vertebral endochondral element" NARROW [https://github.com/obophenotype/uberon/issues/82] xref: VHOG:0001143 xref: VSAO:0000184 is_a: BFO:0000002 is_a: UBERON:0004765 {source="VSAO", source="https://github.com/obophenotype/uberon/issues/82"} ! skeletal element relationship: RO:0002202 UBERON:0003089 {source="cjm"} ! develops from sclerotome property_value: skos:prefLabel "vertebral element" xsd:string [Term] id: UBERON:0010948 name: cleidooccipital muscle def: "A muscle organ that attaches_to a clavicle and attaches_to a occipital bone." [OBOL:automatic] comment: Some studies have indicated a supernumerary cleido-occipital muscle more or less separate from the sterno-cleido-mastoid muscle; The frequency of cleido-occipital muscle occurrence has been reported up to 33% synonym: "cleido-occipitalis" EXACT [] synonym: "cleido-occipitalis muscle" EXACT [] synonym: "cleidooccipital" EXACT [MA:0002276] xref: EMAPA:37688 {source="MA:th"} xref: MA:0002276 xref: NCIT:C52895 is_a: UBERON:0000933 ! chordate pharyngeal muscle is_a: UBERON:0014892 ! skeletal muscle organ, vertebrate intersection_of: UBERON:0014892 ! skeletal muscle organ, vertebrate intersection_of: RO:0002371 UBERON:0001105 ! attached to clavicle bone intersection_of: RO:0002371 UBERON:0001676 ! attached to occipital bone relationship: RO:0002371 UBERON:0001105 ! attached to clavicle bone relationship: RO:0002371 UBERON:0001676 ! attached to occipital bone [Term] id: UBERON:0010949 name: sternooccipital muscle def: "A muscle organ that has_muscle_insertion a occipital bone and has_muscle_origin a sternum." [OBOL:automatic] synonym: "sternooccipital" EXACT [MA:0002385] xref: EMAPA:37702 {source="MA:th"} xref: MA:0002385 xref: NCIT:C53069 xref: UMLS:C1710196 {source="ncithesaurus:Sternooccipital"} is_a: UBERON:0002377 ! muscle of neck intersection_of: UBERON:0014892 ! skeletal muscle organ, vertebrate intersection_of: RO:0002372 UBERON:0000975 ! has muscle origin sternum intersection_of: RO:0002373 UBERON:0001676 ! has muscle insertion occipital bone relationship: RO:0002372 UBERON:0000975 ! has muscle origin sternum relationship: RO:0002373 UBERON:0001676 ! has muscle insertion occipital bone [Term] id: UBERON:0010955 name: trapezius pre-muscle mass xref: EHDAA2:0002079 is_a: UBERON:0005865 {source="EHDAA2"} ! pre-muscle condensation is_a: UBERON:0010258 ! mesenchyme from rhombencephalic neural crest relationship: BFO:0000050 UBERON:0008713 {source="EHDAA2"} ! part of pectoral girdle and thoracic body wall skeletal muscle relationship: RO:0002202 UBERON:0010258 {source="EHDAA2"} ! develops from mesenchyme from rhombencephalic neural crest [Term] id: UBERON:0010959 name: craniocervical muscle def: "Any muscle organ that is part of either the head or the neck." [http://orcid.org/0000-0002-6601-2165] synonym: "muscle of head and neck" RELATED [] synonym: "muscle of head or neck" EXACT [] xref: NCIT:C32716 xref: UMLS:C0448281 {source="ncithesaurus:Head_and_Neck_Muscle"} is_a: UBERON:0014892 ! skeletal muscle organ, vertebrate intersection_of: UBERON:0014892 ! skeletal muscle organ, vertebrate intersection_of: BFO:0000050 UBERON:0007811 ! part of craniocervical region relationship: BFO:0000050 UBERON:0008229 {source="prolog"} ! part of craniocervical region musculature property_value: skos:prefLabel "craniocervical muscle" xsd:string [Term] id: UBERON:0010963 name: trunk and cervical myotome group comment: isa row in EHDAA2 xref: EHDAA2:0003425 is_a: UBERON:0002050 ! embryonic structure is_a: UBERON:0003082 ! myotome relationship: BFO:0000050 UBERON:0005256 {source="EHDAA2"} ! part of trunk mesenchyme [Term] id: UBERON:0010982 name: latissimus dorsi pre-muscle mass xref: EHDAA2:0000933 is_a: UBERON:0005865 {source="EHDAA2"} ! pre-muscle condensation relationship: BFO:0000050 UBERON:0008713 {source="EHDAA2"} ! part of pectoral girdle and thoracic body wall skeletal muscle relationship: RO:0002202 UBERON:0010963 {source="EHDAA2"} ! develops from trunk and cervical myotome group [Term] id: UBERON:0010983 name: levator scapulae pre-muscle mass xref: EHDAA2:0000993 is_a: UBERON:0005865 {source="EHDAA2"} ! pre-muscle condensation relationship: BFO:0000050 UBERON:0008713 {source="EHDAA2"} ! part of pectoral girdle and thoracic body wall skeletal muscle relationship: RO:0002202 UBERON:0010963 {source="EHDAA2"} ! develops from trunk and cervical myotome group [Term] id: UBERON:0010984 name: pectoral pre-muscle mass xref: EHDAA2:0001423 is_a: UBERON:0005865 {source="EHDAA2"} ! pre-muscle condensation relationship: BFO:0000050 UBERON:0008713 {source="EHDAA2"} ! part of pectoral girdle and thoracic body wall skeletal muscle relationship: RO:0002202 UBERON:0010963 {source="EHDAA2"} ! develops from trunk and cervical myotome group [Term] id: UBERON:0010986 name: serratus ventralis pre-muscle mass synonym: "serratus anterior pre-muscle mass" EXACT [EHDAA2:0001833] xref: EHDAA2:0001833 xref: EHDAA:5992 is_a: UBERON:0005865 {source="EHDAA2"} ! pre-muscle condensation relationship: BFO:0000050 UBERON:0003897 {source="EHDAA2"} ! part of axial muscle relationship: RO:0002202 UBERON:0010963 {source="EHDAA2"} ! develops from trunk and cervical myotome group [Term] id: UBERON:0010996 name: articular cartilage of joint def: "A thin layer of cartilage, usually hyaline, on the articular surface of bones in synovial joints." [BTO:0001572] subset: efo_slim subset: human_reference_atlas subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "articular cartilage" EXACT [MA:0000487] synonym: "cartilago articularis" EXACT [FMA:12264] synonym: "hyaline cartilage" RELATED [BTO:0001572] synonym: "joint-associated cartilage" RELATED [AEO:0000179] xref: AEO:0000179 xref: BTO:0001572 xref: CALOHA:TS-0055 xref: EFO:0001902 xref: EMAPA:35149 xref: FMA:12264 xref: GAID:101 xref: galen:ArticularCartilage xref: MA:0000487 xref: MESH:D002358 xref: NCIT:C32144 xref: SCTID:305026006 xref: UMLS:C0007303 {source="ncithesaurus:Articular_Cartilage"} is_a: UBERON:0001994 {source="MA"} ! hyaline cartilage tissue relationship: BFO:0000050 UBERON:0002217 {source="Wikipedia"} ! part of synovial joint property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0011004 name: pharyngeal arch cartilage def: "A cartilage element that is part of a splanchnocranium." [OBOL:automatic] subset: efo_slim synonym: "pharyngeal arch cartilages" EXACT OMO:0003004 [ZFA:0001460] synonym: "splanchnocranium cartilage" EXACT [ZFA:0001460] xref: EFO:0003689 xref: TAO:0001460 xref: ZFA:0001460 is_a: UBERON:0003933 {source="ZFA"} ! cranial cartilage intersection_of: UBERON:0007844 ! cartilage element intersection_of: BFO:0000050 UBERON:0008895 ! part of splanchnocranium relationship: BFO:0000050 UBERON:0008895 {source="ZFA"} ! part of splanchnocranium relationship: RO:0002202 UBERON:0002539 ! develops from pharyngeal arch property_value: skos:prefLabel "pharyngeal arch cartilage" xsd:string [Term] id: UBERON:0011060 name: perilymphatic channel def: "A channel containing perilymph passing through the temporal bone, connecting the scala tympani of the cochlea to the subarachnoid space." [MESH:A09.246.631.246.280, Wikipedia:Perilymphatic_duct] synonym: "cochlear aqueduct" RELATED [FMA:77822, MESH:A09.246.631.246.280] synonym: "ductus perilymphaticus" EXACT [AAO:0000136] synonym: "perilymphatic duct" RELATED [MESH:A09.246.631.246.280] synonym: "perilymphatic space" RELATED [MA:0000248] xref: AAO:0000136 xref: EMAPA:35677 xref: FMA:77822 xref: MA:0000248 xref: SCTID:368950002 xref: Wikipedia:Perilymphatic_duct xref: ZFA:0005461 is_a: UBERON:0000025 ! tube relationship: BFO:0000050 UBERON:0001846 {source="MA"} ! part of internal ear relationship: RO:0002221 UBERON:0001845 ! surrounds perilymph property_value: IAO:0000116 "relationship to FMA class unclear" xsd:string [Term] id: UBERON:0011085 name: palatoquadrate arch def: "The dorsal portion of the first pharyngeal arch, comprising the upper jaw[ZFIN,VHOG]." [https://github.com/obophenotype/uberon/issues/153, VHOG:0000511] subset: efo_slim synonym: "dorsal mandibular arch" RELATED [VHOG:0000511] synonym: "dorsal pharyngeal arch 1" RELATED [VHOG:0000511] synonym: "dorsal visceral arch 1" EXACT [ZFA:0001272] synonym: "dorsal visceral arch 1" RELATED [VHOG:0000511] synonym: "palatoquadrate arch" RELATED [VHOG:0000511] synonym: "upper jaw" RELATED [VHOG:0000511] synonym: "upper pharyngeal jaw" EXACT [ZFA:0001272] synonym: "upper pharyngeal jaw" RELATED [VHOG:0000511] xref: EFO:0003659 xref: TAO:0001272 xref: ZFA:0001272 is_a: BFO:0000002 is_a: UBERON:0010912 {source="cjm"} ! subdivision of skeleton relationship: BFO:0000050 UBERON:0003277 ! part of skeleton of upper jaw relationship: BFO:0000050 UBERON:0008895 {source="VHOG"} ! part of splanchnocranium relationship: RO:0002202 UBERON:0004362 ! develops from pharyngeal arch 1 property_value: skos:prefLabel "palatoquadrate arch" xsd:string property_value: terms:contributor https://orcid.org/0000-0001-9114-8737 property_value: terms:contributor https://orcid.org/0000-0002-6601-2165 [Term] id: UBERON:0011088 name: ligament of knee joint def: "A ligament that is part of a knee joint." [OBOL:automatic] synonym: "knee joint ligament" EXACT [FMA:44580] xref: FMA:44580 xref: SCTID:182440009 is_a: UBERON:0008846 ! skeletal ligament intersection_of: UBERON:0000211 ! ligament intersection_of: BFO:0000050 UBERON:0001485 ! part of knee joint relationship: BFO:0000050 UBERON:0001485 ! part of knee joint [Term] id: UBERON:0011090 name: skeleton of right pelvic girdle def: "A skeleton of pelvic girdle that is part of a right pelvic girdle region." [OBOL:automatic] xref: FMA:87593 is_a: UBERON:0007832 ! pelvic girdle skeleton intersection_of: UBERON:0007832 ! pelvic girdle skeleton intersection_of: BFO:0000050 UBERON:0011092 ! part of right pelvic girdle region relationship: BFO:0000050 UBERON:0011092 ! part of right pelvic girdle region [Term] id: UBERON:0011091 name: skeleton of left pelvic girdle def: "A skeleton of pelvic girdle that is part of a left pelvic girdle region." [OBOL:automatic] xref: FMA:87594 is_a: UBERON:0007832 ! pelvic girdle skeleton intersection_of: UBERON:0007832 ! pelvic girdle skeleton intersection_of: BFO:0000050 UBERON:0011093 ! part of left pelvic girdle region relationship: BFO:0000050 UBERON:0011093 ! part of left pelvic girdle region [Term] id: UBERON:0011092 name: right pelvic girdle region def: "A pelvic girdle region that is in the right side of a multicellular organism." [OBOL:automatic] synonym: "right pelvic girdle" EXACT INCONSISTENT [FMA:16582] xref: FMA:16582 is_a: UBERON:0001271 ! pelvic girdle region intersection_of: UBERON:0001271 ! pelvic girdle region intersection_of: BSPO:0000121 UBERON:0000468 ! multicellular organism relationship: BSPO:0000121 UBERON:0000468 ! multicellular organism relationship: RO:0002551 UBERON:0011090 ! has skeleton skeleton of right pelvic girdle [Term] id: UBERON:0011093 name: left pelvic girdle region def: "A pelvic girdle region that is in the left side of a multicellular organism." [OBOL:automatic] synonym: "left pelvic girdle" EXACT INCONSISTENT [FMA:16583] xref: FMA:16583 is_a: UBERON:0001271 ! pelvic girdle region intersection_of: UBERON:0001271 ! pelvic girdle region intersection_of: BSPO:0000120 UBERON:0000468 ! multicellular organism relationship: BSPO:0000120 UBERON:0000468 ! multicellular organism relationship: RO:0002551 UBERON:0011091 ! has skeleton skeleton of left pelvic girdle [Term] id: UBERON:0011094 name: vertebra cartilage element def: "The cartilaginous form of a vertebral element, a skeletal element that forms around the notochord and is part of the vertebral column." [GO_REF:0000034, http://dx.plos.org/10.1371/journal.pone.0051070, http://orcid.org/0000-0002-6601-2165, VSAO:0000184] synonym: "vertebral cartilage condensation" EXACT [VHOG:0000584] xref: EMAPA:32669 xref: VHOG:0000584 is_a: UBERON:0007844 ! cartilage element is_a: UBERON:0010913 ! vertebral element intersection_of: UBERON:0010913 ! vertebral element intersection_of: RO:0002473 UBERON:0002418 ! composed primarily of cartilage tissue relationship: RO:0002202 UBERON:0011095 ! develops from vertebra pre-cartilage condensation property_value: skos:prefLabel "vertebra cartilage element" xsd:string [Term] id: UBERON:0011095 name: vertebra pre-cartilage condensation def: "The pre-cartilaginous form of a vertebral element, a skeletal element that forms around the notochord and is part of the vertebral column." [GO_REF:0000034, http://dx.plos.org/10.1371/journal.pone.0051070, http://orcid.org/0000-0002-6601-2165, VSAO:0000184] synonym: "vertebral pre-cartilage condensation" EXACT [VHOG:0000582] xref: EMAPA:32671 xref: VHOG:0000582 is_a: UBERON:0010913 ! vertebral element intersection_of: UBERON:0010913 ! vertebral element intersection_of: RO:0002473 UBERON:0005866 ! composed primarily of pre-cartilage condensation relationship: RO:0002387 UBERON:0011094 ! has potential to develop into vertebra cartilage element relationship: RO:0002473 UBERON:0005866 ! composed primarily of pre-cartilage condensation property_value: skos:prefLabel "vertebra pre-cartilage condensation" xsd:string [Term] id: UBERON:0011096 name: lacrimal nerve def: "The lacrimal nerve is the smallest of the three branches of the ophthalmic division of the trigeminal nerve." [Wikipedia:Lacrimal_nerve] subset: human_reference_atlas synonym: "nervus lacrimalis" EXACT OMO:0003011 [Wikipedia:Lacrimal_nerve] xref: FMA:52628 xref: NCIT:C32908 xref: SCTID:280218007 xref: Wikipedia:Lacrimal_nerve is_a: UBERON:0011779 ! nerve of head region intersection_of: UBERON:0001021 ! nerve intersection_of: RO:0002134 UBERON:0001817 ! innervates lacrimal gland relationship: RO:0002134 UBERON:0001817 ! innervates lacrimal gland relationship: RO:0002380 UBERON:0000348 {source="FMA"} ! branching part of ophthalmic nerve property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0011107 name: synovial joint of pelvic girdle def: "A synovial joint that is part of a pelvic girdle region." [OBOL:automatic] synonym: "joint of pelvic girdle" EXACT [] synonym: "pelvic girdle joint" EXACT [FMA:35173] xref: FMA:35173 xref: NCIT:C32890 xref: UMLS:C0827002 {source="ncithesaurus:Joint_of_the_Pelvic_Girdle"} is_a: UBERON:0002217 ! synovial joint is_a: UBERON:0008114 ! joint of girdle intersection_of: UBERON:0002217 ! synovial joint intersection_of: BFO:0000050 UBERON:0001271 ! part of pelvic girdle region relationship: BFO:0000050 UBERON:0001271 ! part of pelvic girdle region relationship: RO:0002176 UBERON:0007830 ! connects pelvic girdle bone/zone [Term] id: UBERON:0011108 name: synovial joint of pectoral girdle def: "A synovial joint that is part of a pectoral girdle region." [OBOL:automatic] synonym: "joint of shoulder girdle" EXACT [] synonym: "pectoral girdle joint" EXACT [FMA:35243] xref: FMA:35243 xref: SCTID:303080001 is_a: UBERON:0002217 ! synovial joint is_a: UBERON:0008114 ! joint of girdle intersection_of: UBERON:0002217 ! synovial joint intersection_of: BFO:0000050 UBERON:0001421 ! part of pectoral girdle region relationship: BFO:0000050 UBERON:0001421 ! part of pectoral girdle region relationship: RO:0002176 UBERON:0007829 ! connects pectoral girdle bone property_value: skos:prefLabel "synovial joint of pectoral girdle" xsd:string [Term] id: UBERON:0011112 name: tibiofibular joint def: "A joint that connects the tibia and the fibula." [https://orcid.org/0000-0002-6601-2165, Wikipedia:Tibiofibular_joint] synonym: "fibulatibial joint" EXACT [] synonym: "fibulotibial joint" EXACT [] synonym: "tibiafibular joint" EXACT [] xref: FMA:35181 xref: SCTID:244554002 xref: Wikipedia:Tibiofibular_joint is_a: UBERON:0002210 {source="FMA"} ! syndesmosis is_a: UBERON:0003840 ! hindlimb joint intersection_of: UBERON:0000982 ! skeletal joint intersection_of: BFO:0000050 UBERON:0003823 ! part of hindlimb zeugopod intersection_of: RO:0002176 UBERON:0000979 ! connects tibia intersection_of: RO:0002176 UBERON:0001446 ! connects fibula relationship: BFO:0000050 UBERON:0003823 ! part of hindlimb zeugopod relationship: RO:0002176 UBERON:0000979 ! connects tibia relationship: RO:0002176 UBERON:0001446 ! connects fibula property_value: IAO:0000116 "we include location as part of the logical definition to prevent accidental classification of ankle joints as tibiofibular joints" xsd:string [Term] id: UBERON:0011118 name: tarsometatarsal joint def: "The tarsometatarsal articulations are arthrodial joints in the pes." [Wikipedia:Tarsometatarsal_articulations] subset: pheno_slim synonym: "articulationes tarsometatarsales" RELATED OMO:0003011 [Wikipedia:Tarsometatarsal_articulations] synonym: "cuboideometatarsal" RELATED [Wikipedia:Tarsometatarsal_articulations] synonym: "Lisfranc joint" RELATED [Wikipedia:Tarsometatarsal_articulations] synonym: "tarso-metatarsal join" EXACT [] synonym: "tarsometatarsal" RELATED [Wikipedia:Tarsometatarsal_articulations] synonym: "tarsometatarsal articulation" RELATED [Wikipedia:Tarsometatarsal_articulations] xref: FMA:35216 xref: SCTID:182222008 xref: Wikipedia:Tarsometatarsal_articulations is_a: UBERON:0001487 ! pes joint intersection_of: UBERON:0000982 ! skeletal joint intersection_of: RO:0002176 UBERON:0001447 ! connects tarsal bone intersection_of: RO:0002176 UBERON:0001448 ! connects metatarsal bone relationship: RO:0002176 UBERON:0001447 ! connects tarsal bone relationship: RO:0002176 UBERON:0001448 ! connects metatarsal bone property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/8/8e/Gray355.png" xsd:anyURI property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/d/dc/Gray358.png" xsd:anyURI [Term] id: UBERON:0011119 name: carpometacarpal joint def: "The carpometacarpal joints (CMC) are joints in the wrist that articulates the distal row of carpal bones and the proximal bases of the metacarpal bones." [Wikipedia:Carpometacarpal_joint] synonym: "articulationes carpometacarpeæ" EXACT OMO:0003011 [Wikipedia:Carpometacarpal_joint] synonym: "carpometacarpal" BROAD [Wikipedia:Carpometacarpal_joint] synonym: "carpometacarpal articulation" RELATED [Wikipedia:Carpometacarpal_joint] synonym: "CMJ" BROAD [Wikipedia:Carpometacarpal_joint] xref: FMA:35287 xref: NCIT:C32265 xref: SCTID:361842002 xref: UMLS:C0224620 {source="ncithesaurus:Carpometacarpal_Joint"} xref: Wikipedia:Carpometacarpal_joint is_a: UBERON:0001489 ! manus joint intersection_of: UBERON:0000982 ! skeletal joint intersection_of: RO:0002176 UBERON:0001435 ! connects carpal bone intersection_of: RO:0002176 UBERON:0002374 ! connects metacarpal bone relationship: RO:0002176 UBERON:0001435 ! connects carpal bone relationship: RO:0002176 UBERON:0002374 ! connects metacarpal bone property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/7/7c/Gray335.png" xsd:anyURI [Term] id: UBERON:0011120 name: laryngeal joint def: "A skeletal joint that connects a laryngeal cartilage." [OBOL:automatic] synonym: "joint of larynx" EXACT [FMA:55100] synonym: "laryngeal articulation" EXACT [FMA:55100] xref: FMA:55100 is_a: UBERON:0002217 {source="FMA"} ! synovial joint intersection_of: UBERON:0000982 ! skeletal joint intersection_of: RO:0002176 UBERON:0001739 ! connects laryngeal cartilage relationship: BFO:0000050 UBERON:0010323 ! part of cranial skeletal system relationship: RO:0002176 UBERON:0001739 ! connects laryngeal cartilage property_value: skos:prefLabel "laryngeal joint" xsd:string [Term] id: UBERON:0011131 name: intermetacarpal joint def: "A skeletal joint that connects two adjacent metacarpals[FMA,modified]." [FMA:35288] synonym: "intermetacarpal" RELATED [Wikipedia:Intermetacarpal_articulations] synonym: "intermetacarpal articulation" RELATED [Wikipedia:Intermetacarpal_articulations] xref: FMA:35288 xref: SCTID:303065007 xref: Wikipedia:Intermetacarpal_articulations is_a: UBERON:0001489 ! manus joint intersection_of: UBERON:0000982 ! skeletal joint intersection_of: RO:0002176 UBERON:0002374 {cardinality="2"} ! connects metacarpal bone relationship: BFO:0000050 UBERON:0004453 ! part of metacarpus region relationship: RO:0002176 UBERON:0002374 ! connects metacarpal bone [Term] id: UBERON:0011132 name: intercarpal joint def: "A skeletal joint that connects two carpal bones." [http://orcid.org/0000-0002-6601-2165] synonym: "carpal joint" EXACT [FMA:35292] synonym: "intercarpal" RELATED [Wikipedia:Intercarpal_articulations] synonym: "intercarpal articulation" RELATED [Wikipedia:Intercarpal_articulations] synonym: "midcarpal articulation" RELATED [Wikipedia:Intercarpal_articulations] xref: FMA:35292 xref: MESH:D050824 {sssom:mapping_justification="https://w3id.org/semapv/vocab/LexicalMatching"} xref: NCIT:C32264 xref: SCTID:182176003 xref: UMLS:C1262468 {source="ncithesaurus:Carpal_Joint"} xref: Wikipedia:Intercarpal_articulations is_a: UBERON:0001489 ! manus joint intersection_of: UBERON:0000982 ! skeletal joint intersection_of: RO:0002176 UBERON:0001435 {cardinality="2"} ! connects carpal bone relationship: BFO:0000050 UBERON:0004452 {source="FMA"} ! part of carpal region relationship: RO:0002176 UBERON:0001435 ! connects carpal bone property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/3/37/Gray336.png" xsd:anyURI [Term] id: UBERON:0011133 name: intermetatarsal joint def: "A joint that connects two adjacent metatarsals." [Wikipedia:Intermetatarsal_articulations] xref: FMA:35219 xref: SCTID:361868009 xref: Wikipedia:Intermetatarsal_articulations is_a: UBERON:0001487 ! pes joint intersection_of: UBERON:0000982 ! skeletal joint intersection_of: RO:0002176 UBERON:0001448 {cardinality="2"} ! connects metatarsal bone relationship: BFO:0000050 UBERON:0000983 ! part of metatarsus region relationship: RO:0002176 UBERON:0001448 ! connects metatarsal bone property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/d/dc/Gray358.png" xsd:anyURI [Term] id: UBERON:0011134 name: nonsynovial joint def: "Joint in which the articulating bones or cartilages are connected by ligaments or fibrocartilage without an intervening synovial cavity. Examples: sagittal suture, inferior tibiofibular syndesmosis, costochondral joint, pubic symphysis." [FMA:7491] synonym: "solid joint" EXACT [FMA:7491] xref: FMA:7491 is_a: UBERON:0000982 {source="FMA"} ! skeletal joint property_value: skos:prefLabel "nonsynovial joint" xsd:string [Term] id: UBERON:0011135 name: intervertebral cartilage def: "A cartilage element that lies between two successive vertebral centra." [ISBN:0073040584] xref: AAO:0000795 is_a: UBERON:0007844 ! cartilage element intersection_of: UBERON:0007844 ! cartilage element intersection_of: RO:0002220 UBERON:0001075 {cardinality="2"} ! adjacent to bony vertebral centrum relationship: BFO:0000050 UBERON:0001468 {source="FMA", source="MA"} ! part of intervertebral joint relationship: RO:0002220 UBERON:0001075 ! adjacent to bony vertebral centrum [Term] id: UBERON:0011136 name: ligament of vertebral column def: "Ligament that joins successive centra. Important in controlling the stiffness of the vertebral column when it flexes." [ISBN:0073040584] synonym: "intervertebral ligament" BROAD [] synonym: "vertebral centrum ligament" BROAD [] synonym: "vertebral column ligament" EXACT [FMA:31892] xref: FMA:31892 xref: SCTID:244590009 is_a: UBERON:0008846 ! skeletal ligament intersection_of: UBERON:0008846 ! skeletal ligament intersection_of: RO:0002371 UBERON:0001075 ! attached to bony vertebral centrum relationship: BFO:0000050 UBERON:0001130 ! part of vertebral column relationship: RO:0002371 UBERON:0001075 ! attached to bony vertebral centrum [Term] id: UBERON:0011137 name: axial skeletal system def: "Subdivision of the skeletal system which consists of the axial skeleton plus associated joints." [https://orcid.org/0000-0002-6601-2165] xref: FMA:7483 is_a: UBERON:0000075 {source="FMA"} ! subdivision of skeletal system relationship: BFO:0000051 UBERON:0000982 ! has part skeletal joint property_value: seeAlso "http://purl.obolibrary.org/obo/uberon/docs/The-axial-skeleton" xsd:anyURI property_value: skos:prefLabel "axial skeletal system" xsd:string [Term] id: UBERON:0011138 name: postcranial axial skeletal system def: "Subdivision of the skeletal system which consists of the postcranial axial skeleton plus associated joints." [https://github.com/obophenotype/uberon/issues/44, https://orcid.org/0000-0002-6601-2165] synonym: "axial skeletal system" BROAD [https://github.com/obophenotype/uberon/wiki/The-axial-skeleton] synonym: "post-cranial axial skeletal system" EXACT [] xref: FMA:302077 is_a: BFO:0000002 is_a: UBERON:0000075 {source="FMA"} ! subdivision of skeletal system relationship: RO:0002202 UBERON:0003089 {source="cjm"} ! develops from sclerotome property_value: seeAlso "http://purl.obolibrary.org/obo/uberon/docs/The-axial-skeleton" xsd:anyURI property_value: skos:prefLabel "postcranial axial skeletal system" xsd:string property_value: terms:contributor https://orcid.org/0000-0002-6601-2165 [Term] id: UBERON:0011139 name: synovial limb joint def: "Any synovial joint that is part of a (free) limb." [https://orcid.org/0000-0002-6601-2165] comment: Most limb joints are synovial, but a few such as the tibiofibular joints are syndesmoses. synonym: "synovial joint of free limb segment" EXACT [FMA:258776] xref: FMA:258776 is_a: UBERON:0002217 ! synovial joint is_a: UBERON:0003657 ! limb joint intersection_of: UBERON:0002217 ! synovial joint intersection_of: BFO:0000050 UBERON:0002101 ! part of limb [Term] id: UBERON:0011141 name: appendicular ossicle def: "Ossicle that is part of the appendicular skeleton." [PSPUB:0000169, VSAO:0000131] comment: Examples of appendicular ossicles include the patella and meniscus of the knee joint. synonym: "ossicle of appendicular skeleton" EXACT [OBOL:automatic] xref: VSAO:0000131 xref: XAO:0004194 is_a: UBERON:0010911 ! ossicle intersection_of: UBERON:0010911 ! ossicle intersection_of: BFO:0000050 UBERON:0002091 ! part of appendicular skeleton relationship: BFO:0000050 UBERON:0002091 ! part of appendicular skeleton [Term] id: UBERON:0011142 name: axial ossicle def: "Ossicle that is part of the axial skeleton." [PSPUB:0000169, VSAO:0000133] comment: Examples of axial ossicles include the ossified tendons adjacent to the neural spines of the vertebral column. synonym: "ossicle of axial skeleton" EXACT [OBOL:automatic] synonym: "ossicle of postcranial-axial skeleton" EXACT [OBOL:automatic] synonym: "vertebral ossicle" RELATED [OBOL:automatic] xref: VSAO:0000133 is_a: UBERON:0010911 ! ossicle intersection_of: UBERON:0010911 ! ossicle intersection_of: BFO:0000050 UBERON:0002090 ! part of postcranial axial skeleton relationship: BFO:0000050 UBERON:0002090 ! part of postcranial axial skeleton [Term] id: UBERON:0011143 name: upper urinary tract def: "Subdivision of urinary system which consists of the kidney and the ureters." [FMA:45658] subset: human_reference_atlas subset: pheno_slim xref: FMA:45658 xref: galen:UpperUrinaryTract xref: NCIT:C61107 xref: SCTID:181413006 is_a: BFO:0000002 is_a: UBERON:0011216 ! organ system subdivision is_a: UBERON:0015212 ! lateral structure relationship: BFO:0000051 UBERON:0000056 ! has part ureter relationship: BFO:0000051 UBERON:0002113 ! has part kidney relationship: BSPO:0000126 UBERON:0001008 {source="FMA-abduced-lr"} ! renal system property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0011148 name: submucosal gland def: "Gland of the lamina epithelialis mucosae which perforate the lamina muscularis, with their adenomeres located in the submucosal connective tissue." [BTO:0003751, Wikipedia:Submucosal_glands] xref: BTO:0003751 xref: EMAPA:37970 {source="MA:th"} xref: Wikipedia:Submucosal_glands is_a: UBERON:0000414 ! mucous gland intersection_of: UBERON:0000414 ! mucous gland intersection_of: RO:0001025 UBERON:0000009 ! located in submucosa relationship: RO:0001025 UBERON:0000009 ! located in submucosa relationship: RO:0002150 UBERON:0003350 ! continuous with epithelium of mucosa property_value: skos:prefLabel "submucosal gland" xsd:string [Term] id: UBERON:0011156 name: facial skeleton def: "Subdivision of skull that consists of the facial bones." [http://www.bartleby.com/107/37.html, https://orcid.org/0000-0002-6601-2165, MP:0005274, Wikipedia:Facial_skeleton] subset: pheno_slim synonym: "facial bone" RELATED [MA:0000318] synonym: "facial skeleton" EXACT [FMA:53673] synonym: "ossa facialia" RELATED OMO:0003011 [Wikipedia:Facial_skeleton] synonym: "ossa faciei" RELATED OMO:0003011 [Wikipedia:Facial_skeleton] synonym: "viscerocranium" RELATED INCONSISTENT [MA:0000318] xref: EHDAA2:0002206 xref: EHDAA:8361 xref: EMAPA:18022 xref: FMA:53673 xref: MA:0000318 xref: Wikipedia:Facial_skeleton is_a: UBERON:0010313 ! neural crest-derived structure is_a: UBERON:0011158 {source="FMA"} ! primary subdivision of skull relationship: BFO:0000050 UBERON:0001456 {source="FMA"} ! part of face property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/7/77/Illu_facial_bones.jpg" xsd:anyURI property_value: skos:prefLabel "facial skeleton" xsd:string [Term] id: UBERON:0011158 name: primary subdivision of skull def: "The skull can be divided into two: the neurocranium and the facial skeleton." [http://orcid.org/0000-0002-6601-2165] subset: non_informative synonym: "skull subdivision" EXACT [FMA:54964] synonym: "subdivision of skull" EXACT [FMA:54964] xref: FMA:54964 is_a: UBERON:0000075 {source="FMA"} ! subdivision of skeletal system relationship: BFO:0000050 UBERON:0003129 ! part of skull property_value: skos:prefLabel "primary subdivision of skull" xsd:string [Term] id: UBERON:0011159 name: primary subdivision of cranial skeletal system subset: non_informative is_a: UBERON:0000075 {source="FMA"} ! subdivision of skeletal system relationship: BFO:0000050 UBERON:0010323 ! part of cranial skeletal system property_value: skos:prefLabel "primary subdivision of cranial skeletal system" xsd:string [Term] id: UBERON:0011164 name: neurocranium bone def: "A bone that is part of a neurocranium [Automatically generated definition]." [OBOL:automatic] synonym: "chondrocranium bone" EXACT [MA:0001478] xref: EMAPA:35238 xref: MA:0001478 xref: SCTID:120229002 is_a: UBERON:0003457 ! head bone is_a: UBERON:0004766 ! cranial bone intersection_of: UBERON:0001474 ! bone element intersection_of: BFO:0000050 UBERON:0001703 ! part of neurocranium relationship: BFO:0000050 UBERON:0001703 ! part of neurocranium property_value: skos:prefLabel "neurocranium bone" xsd:string [Term] id: UBERON:0011171 name: joint connecting upper and lower jaws def: "Synovial joint that articulates bones of upper and lower jaw." [http://evolution.berkeley.edu/evolibrary/article/evograms_05, https://orcid.org/0000-0002-6601-2165] synonym: "craniomandibular joint" NARROW [] synonym: "jaw joint" BROAD [] is_a: UBERON:0002217 {source="abduced"} ! synovial joint intersection_of: UBERON:0000982 ! skeletal joint intersection_of: RO:0002176 UBERON:0003277 ! connects skeleton of upper jaw intersection_of: RO:0002176 UBERON:0003278 ! connects skeleton of lower jaw relationship: RO:0002176 UBERON:0003277 ! connects skeleton of upper jaw relationship: RO:0002176 UBERON:0003278 ! connects skeleton of lower jaw property_value: skos:prefLabel "joint connecting upper and lower jaws" xsd:string [Term] id: UBERON:0011172 name: retrorubral area of midbrain reticular nucleus def: "The term retrorubral area of the midbrain reticular nucleus refers to a region of the rat brain caudal and dorsal to the ventral tegmental area. It is one of three parts of the midbrain reticular nucleus; the other two are the magnocellular part of the midbrain reticular nucleus and the parvicellular part of the midbrain reticular nucleus (Swanson-2004). BrainInfo distinguishes between the Retrorubral area of the midbrain reticular formation and the retrorubral nucleus." [NLXANAT:20090301] synonym: "A8" BROAD [NLXANAT:20090301] synonym: "area 11 of Brodmann (guenon)" RELATED [NeuroNames:1036] synonym: "area orbitalis interna" RELATED OMO:0003011 [NeuroNames:1036] synonym: "brodmann's area 11" RELATED [NeuroNames:1036] synonym: "midbraiin reticular nucleus, retrorubral area" RELATED [BAMS:RR] synonym: "midbrain reticular nucleus, retrorubral area" EXACT [ABA:RR] synonym: "retrorubal field" BROAD [http://braininfo.rprc.washington.edu/] synonym: "retrorubral area" EXACT [NLXANAT:20090301] synonym: "retrorubral field" RELATED [BAMS:RR] synonym: "retrorubral nucleus" RELATED [BAMS:RR] xref: BAMS:RR xref: DHBA:12289 xref: DMBA:16884 xref: MBA:246 xref: neuronames:1036 {source="NLXANAT:20090301"} xref: NLXANAT:20090301 is_a: UBERON:0002616 ! regional part of brain relationship: BFO:0000050 UBERON:0007415 {source="Obol"} ! part of nucleus of midbrain reticular formation property_value: skos:prefLabel "retrorubral area of midbrain reticular nucleus" xsd:string [Term] id: UBERON:0011184 name: epithelium of crypt of Lieberkuhn def: "An epithelium that is part of a crypt of Lieberkuhn." [OBOL:automatic] subset: human_reference_atlas synonym: "crypt epithelium" BROAD [] synonym: "intestinal crypt epithelium" EXACT [] xref: NCIT:C83191 xref: UMLS:C2826787 {source="ncithesaurus:Crypt_Epithelium"} is_a: UBERON:0001277 ! intestinal epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: BFO:0000050 UBERON:0001983 ! part of crypt of Lieberkuhn relationship: BFO:0000050 UBERON:0001983 ! part of crypt of Lieberkuhn property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0011185 name: gastrointestinal sphincter def: "A sphincter muscle that is part of the gastrointestinal system." [OBOL:automatic] xref: NCIT:C32669 xref: UMLS:C1517464 {source="ncithesaurus:Gastrointestinal_Sphincter"} is_a: UBERON:0004590 ! sphincter muscle is_a: UBERON:0013765 ! digestive system element intersection_of: UBERON:0004590 ! sphincter muscle intersection_of: BFO:0000050 UBERON:0005409 ! part of alimentary part of gastrointestinal system relationship: BFO:0000050 UBERON:0005409 ! part of alimentary part of gastrointestinal system property_value: skos:prefLabel "gastrointestinal sphincter" xsd:string [Term] id: UBERON:0011189 name: lamina propria of large intestine def: "A lamina propria that is part of a large intestine." [OBOL:automatic] subset: human_reference_atlas synonym: "lamina propria of mucosa of large intestine" EXACT [FMA:15654] synonym: "large intestinal lamina propria" EXACT [] synonym: "large intestine lamina propria" EXACT [FMA:15654] xref: FMA:15654 xref: NCIT:C49298 xref: UMLS:C1708644 {source="ncithesaurus:Large_Intestinal_Lamina_Propria"} is_a: UBERON:0004780 ! gastrointestinal system lamina propria intersection_of: UBERON:0000030 ! lamina propria intersection_of: BFO:0000050 UBERON:0000059 ! part of large intestine relationship: BFO:0000050 UBERON:0001207 {source="FMA"} ! part of mucosa of large intestine property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "lamina propria of large intestine" xsd:string [Term] id: UBERON:0011191 name: ophthalmic vein def: "Ophthalmic veins are veins which drain the eye. More specifically, they can refer to: Superior ophthalmic vein Inferior ophthalmic vein." [Wikipedia:Ophthalmic_veins] synonym: "opthalmic vein" EXACT [EHDAA2:0004113] synonym: "vena ophthalmica" RELATED [Wikipedia:Ophthalmic_veins] xref: EHDAA2:0004113 xref: EMAPA:19313 xref: Wikipedia:Ophthalmic_veins xref: XAO:0004169 is_a: UBERON:0009141 {source="EHDAA2-modified"} ! craniocervical region vein property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/0/02/Gray572.png" xsd:anyURI property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/blood-vasculature-female/v1.3/assets/3d-vh-f-blood-vasculature.glb" xsd:anyURI property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/blood-vasculature-male/v1.3/assets/3d-vh-m-blood-vasculature.glb" xsd:anyURI [Term] id: UBERON:0011192 name: superior ophthalmic vein def: "The superior ophthalmic vein begins at the inner angle of the orbit in a vein named the nasofrontal which communicates anteriorly with the angular vein; it pursues the same course as the ophthalmic artery, and receives tributaries corresponding to the branches of that vessel. Forming a short single trunk, it passes between the two heads of the Rectus lateralis and through the medial part of the superior orbital fissure, and ends in the cavernous sinus. The ethmoidal veins drain into the superior ophthalmic vein. Vorticose veins also drain into the superior ophthalmic vein." [Wikipedia:Superior_ophthalmic_vein] subset: human_reference_atlas synonym: "anterior ethmoidal vein" RELATED [Wikipedia:Superior_ophthalmic_vein] synonym: "posterior ethmoidal vein" RELATED [Wikipedia:Superior_ophthalmic_vein] synonym: "superior ophthalmic" RELATED [Wikipedia:Superior_ophthalmic_vein] synonym: "superior opthalmic vein" RELATED [] xref: FMA:51246 xref: SCTID:149481004 xref: Wikipedia:Superior_ophthalmic_vein is_a: UBERON:0011191 ! ophthalmic vein relationship: RO:0002170 UBERON:0003712 ! connected to cavernous sinus property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/0/02/Gray572.png" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0011197 name: parathyroid epithelium def: "An epithelium that is part of a parathyroid gland." [OBOL:automatic] xref: CALOHA:TS-2141 xref: NCIT:C48258 xref: UMLS:C1709466 {source="ncithesaurus:Parathyroid_Gland_Epithelial_Tissue"} is_a: UBERON:0000486 {source="EHDAA2-abduced"} ! multilaminar epithelium is_a: UBERON:0005911 ! endo-epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: BFO:0000050 UBERON:0001132 ! part of parathyroid gland relationship: BFO:0000050 UBERON:0001132 ! part of parathyroid gland relationship: RO:0002202 UBERON:0004117 ! develops from pharyngeal pouch relationship: RO:0002473 CL:0002260 ! composed primarily of epithelial cell of parathyroid gland [Term] id: UBERON:0011198 name: muscle layer of large intestine def: "A muscle layer that is part of a large intestine." [OBOL:automatic] synonym: "muscular coat of large intestine" EXACT [FMA:14971] synonym: "muscular layer of large intestine" EXACT [FMA:14971] synonym: "muscularis externa of large intestine" EXACT [FMA:14971] synonym: "tunica muscularis intestini crassi" EXACT OMO:0003011 [FMA:TA] xref: FMA:14971 xref: NCIT:C32927 xref: UMLS:C0734205 {source="ncithesaurus:Large_Intestinal_Muscular_Coat"} is_a: UBERON:0012367 ! muscle layer of intestine intersection_of: UBERON:0006660 ! muscular coat intersection_of: BFO:0000050 UBERON:0000059 ! part of large intestine relationship: BFO:0000050 UBERON:0001169 {source="FMA"} ! part of wall of large intestine property_value: skos:prefLabel "muscle layer of large intestine" xsd:string [Term] id: UBERON:0011201 name: muscle layer of small intestine def: "A muscle layer that is part of a small intestine." [OBOL:automatic] synonym: "muscular coat of small intestine" EXACT [FMA:14932] synonym: "muscular layer of small intestine" EXACT [FMA:14932] synonym: "muscularis externa of small intestine" EXACT [FMA:14932] synonym: "small intestine muscularis propria" EXACT [FMA:14932] synonym: "tunica muscularis (intestinum tenue)" EXACT [FMA:14932] synonym: "tunica muscularis intestini tenuis" EXACT OMO:0003011 [FMA:TA] xref: FMA:14932 xref: NCIT:C33569 xref: SCTID:362145004 xref: UMLS:C0227269 {source="ncithesaurus:Small_Intestinal_Muscular_Coat"} is_a: UBERON:0012367 ! muscle layer of intestine intersection_of: UBERON:0006660 ! muscular coat intersection_of: BFO:0000050 UBERON:0002108 ! part of small intestine relationship: BFO:0000050 UBERON:0001168 {source="FMA"} ! part of wall of small intestine property_value: skos:prefLabel "muscle layer of small intestine" xsd:string [Term] id: UBERON:0011213 name: root of vagus nerve def: "A root of cranial nerve that is part of a vagus nerve." [OBOL:automatic] synonym: "rootlet of vagus nerve" EXACT [FMA:6213] synonym: "rX" BROAD [ZFA:0007011] synonym: "vagal root" EXACT [ZFA:0007011] synonym: "vagus nerve root" EXACT [BIRNLEX:1456] synonym: "vagus neural rootlet" RELATED [FMA:6213] synonym: "vagus root" EXACT [ZFA:0007011] xref: BIRNLEX:1456 xref: DHBA:12888 xref: DMBA:17748 xref: FMA:6213 xref: HBA:9337 xref: ZFA:0007011 is_a: UBERON:0002211 ! nerve root intersection_of: UBERON:0002211 ! nerve root intersection_of: extends_fibers_into UBERON:0001759 ! vagus nerve relationship: extends_fibers_into UBERON:0001759 ! vagus nerve property_value: skos:prefLabel "root of vagus nerve" xsd:string [Term] id: UBERON:0011214 name: nucleus of midbrain tectum def: "A neural nucleus that is part of a midbrain tectum." [OBOL:automatic] synonym: "nucleus of tectum" EXACT [FMA:258766] synonym: "tectal nucleus" BROAD [] xref: FMA:258766 is_a: UBERON:0009661 ! midbrain nucleus intersection_of: UBERON:0000125 ! neural nucleus intersection_of: BFO:0000050 UBERON:0002314 ! part of midbrain tectum relationship: BFO:0000050 UBERON:0002314 ! part of midbrain tectum property_value: skos:prefLabel "nucleus of midbrain tectum" xsd:string [Term] id: UBERON:0011215 name: central nervous system cell part cluster def: "A multi cell part structure that is part of a central nervous system." [OBOL:automatic] subset: upper_level synonym: "cell part cluster of neuraxis" EXACT [FMA:83143] synonym: "neuraxis layer" EXACT [FMA:83143] xref: FMA:83143 is_a: UBERON:0005162 ! multi cell part structure intersection_of: UBERON:0005162 ! multi cell part structure intersection_of: BFO:0000050 UBERON:0001017 ! part of central nervous system relationship: BFO:0000050 UBERON:0001017 ! part of central nervous system property_value: skos:prefLabel "central nervous system cell part cluster" xsd:string [Term] id: UBERON:0011216 name: organ system subdivision def: "A subdivision of an anatomical system." [http://orcid.org/0000-0002-6601-2165] subset: common_anatomy subset: human_reference_atlas subset: upper_level xref: FBbt:00007330 {sssom:mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"} xref: FMA:67509 xref: SCTID:91690000 is_a: UBERON:0010000 {source="FBbt"} ! multicellular anatomical structure relationship: BFO:0000050 UBERON:0000467 ! part of anatomical system property_value: RO:0002175 NCBITaxon:33090 property_value: RO:0002175 NCBITaxon:33208 property_value: RO:0002175 NCBITaxon:4751 property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "organ system subdivision" xsd:string [Term] id: UBERON:0011222 name: intra-ocular muscle synonym: "intrinsic muscle of eyeball" EXACT [] synonym: "intrinsic ocular muscle" EXACT [EMAPA:18808] xref: AAO:0010038 xref: EMAPA:18808 xref: FMA:49150 is_a: UBERON:0004277 ! eye muscle relationship: BFO:0000050 UBERON:0003386 {source="EMAPA"} ! part of smooth muscle of eye property_value: skos:prefLabel "intra-ocular muscle" xsd:string [Term] id: UBERON:0011233 name: synovial membrane of synovial tendon sheath def: "Synovial sac which surrounds parts of one or more tendons. Examples: synovial tendon sheath of manual digit 2, radial bursa." [FMA:45087, Wikipedia:Synovial_sheath] comment: Alternate def: A synovial sheath is a layer of a tendon sheath containing tendons in the hand and foot. They lie internal to the fibrous tendon sheaths. An example is the common synovial sheath for the flexor tendons. [Wikipedia:Synovial_sheath] synonym: "synovium" BROAD [BTO:0001823] xref: BTO:0001823 xref: FMA:40878 xref: Wikipedia:Synovial_sheath is_a: UBERON:0007616 ! layer of synovial tissue intersection_of: UBERON:0007616 ! layer of synovial tissue intersection_of: RO:0002007 UBERON:0000304 ! bounding layer of tendon sheath relationship: RO:0002007 UBERON:0000304 ! bounding layer of tendon sheath property_value: skos:prefLabel "synovial membrane of synovial tendon sheath" xsd:string [Term] id: UBERON:0011234 name: fibrous membrane of synovial tendon sheath xref: FMA:40877 is_a: UBERON:0004923 ! organ component layer intersection_of: UBERON:0004923 ! organ component layer intersection_of: RO:0002007 UBERON:0000304 ! bounding layer of tendon sheath intersection_of: RO:0002473 UBERON:0011824 ! composed primarily of fibrous connective tissue relationship: RO:0002007 UBERON:0000304 ! bounding layer of tendon sheath relationship: RO:0002473 UBERON:0011824 ! composed primarily of fibrous connective tissue property_value: skos:prefLabel "fibrous membrane of synovial tendon sheath" xsd:string [Term] id: UBERON:0011241 name: ethmoid region def: "The most anterior region of the braincase. Provides structural support for peripheral olfactory organ." [http://palaeos.com/vertebrates/bones/braincase/ethmoid.html, UBERONREF:0000007] xref: AAO:0000986 is_a: BFO:0000002 is_a: UBERON:0034921 ! multi organ part structure relationship: BFO:0000050 UBERON:0003112 ! part of olfactory region relationship: RO:0002254 UBERON:0005945 ! has developmental contribution from neurocranial trabecula property_value: skos:prefLabel "ethmoid region" xsd:string [Term] id: UBERON:0011249 name: appendicular skeletal system def: "Subdivision of the skeletal system which consists of the appendicular skeleton plus associated joints." [https://orcid.org/0000-0002-6601-2165] xref: FMA:7484 xref: VSAO:0000306 is_a: UBERON:0000075 ! subdivision of skeletal system relationship: BFO:0000051 UBERON:0000982 ! has part skeletal joint relationship: BFO:0000051 UBERON:0002091 ! has part appendicular skeleton property_value: seeAlso "https://github.com/obophenotype/uberon/wiki/Appendages-and-the-appendicular-skeleton" xsd:anyURI property_value: skos:prefLabel "appendicular skeletal system" xsd:string [Term] id: UBERON:0011250 name: autopod bone def: "A bone that is part of a autopod region. Note that this incudes the carpal and tarsal bones." [https://orcid.org/0000-0002-6601-2165] is_a: UBERON:0002428 ! limb bone is_a: UBERON:0015063 ! autopod endochondral element intersection_of: UBERON:0015063 ! autopod endochondral element intersection_of: RO:0002473 UBERON:0002481 ! composed primarily of bone tissue relationship: RO:0002202 UBERON:0015064 ! develops from autopod cartilage [Term] id: UBERON:0011270 name: dorsal trunk def: "The part of the trunk that is in the dorsum[cjm]." [UBERONREF:0000006, Wikipedia:Human_back] synonym: "back of trunk" EXACT [FMA:25056] synonym: "dorsal part of trunk" EXACT [] synonym: "dorsum of trunk" EXACT [FMA:25056] synonym: "trunk back" EXACT [FMA:25056] xref: EMAPA:35162 xref: FMA:25056 xref: MA:0000020 xref: Wikipedia:Human_back is_a: UBERON:0009569 {source="FMA"} ! subdivision of trunk relationship: BFO:0000050 UBERON:0001137 {source="FMA"} ! part of dorsum property_value: skos:prefLabel "dorsal trunk" xsd:string [Term] id: UBERON:0011272 name: embryonic skin basal layer synonym: "basal cell layer of skin" RELATED [] synonym: "outer epithelium of body" RELATED [Wikipathways:WP2062] xref: EHDAA2:0001845 is_a: BFO:0000002 is_a: UBERON:0000490 {source="EHDAA2"} ! unilaminar epithelium relationship: BFO:0000050 UBERON:0002199 {source="EHDAA2"} ! part of integument relationship: RO:0002202 UBERON:0000076 {source="EHDAA2"} ! develops from external ectoderm property_value: IAO:0000116 "compare with 'stratum basale of epidermis'. This class is the source for many adult structures - see WP2062. See also: 'enveloping layer of ectoderm'" xsd:string property_value: skos:prefLabel "embryonic skin basal layer" xsd:string [Term] id: UBERON:0011289 name: pharyngobasilar fascia def: "The pharyngeal aponeurosis (or pharyngobasilar fascia, or fibrous coat), is situated between the mucous and muscular layers. It is thick above where the muscular fibers are wanting, and is firmly connected to the basilar portion of the occipital and the petrous portions of the temporal bones. As it descends it diminishes in thickness, and is gradually lost. It is strengthened posteriorly by a strong fibrous band, which is attached above to the pharyngeal spine on the under surface of the basilar portion of the occipital bone, and passes downward, forming a median raphe, which gives attachment to the Constrictores pharyngis." [Wikipedia:Pharyngobasilar_fascia] synonym: "pharyngeal aponeurosis" EXACT [FMA:55074] synonym: "pharyngeal aponeurosis" RELATED [Wikipedia:Pharyngobasilar_fascia] xref: FMA:55074 xref: SCTID:16675008 xref: Wikipedia:Pharyngobasilar_fascia is_a: UBERON:0006614 {source="FMA"} ! aponeurosis intersection_of: UBERON:0006614 ! aponeurosis intersection_of: BFO:0000050 UBERON:0001042 ! part of chordate pharynx relationship: BFO:0000050 UBERON:0001042 ! part of chordate pharynx [Term] id: UBERON:0011298 name: submucosa of fallopian tube def: "The submucous layer of the wall of the uterine tube." [BTO:0002116] synonym: "submucosa of uterine tube" EXACT [] synonym: "submucous layer of uterine tube" RELATED [BTO:0002116] synonym: "tela submucosa tubae uterinae" EXACT OMO:0003011 [BTO:0002116] synonym: "uterine submucosa" RELATED [] xref: BTO:0002116 xref: SCTID:245489008 is_a: UBERON:0000009 ! submucosa is_a: UBERON:0005156 ! reproductive structure intersection_of: UBERON:0000009 ! submucosa intersection_of: BFO:0000050 UBERON:0003889 ! part of fallopian tube relationship: BFO:0000050 UBERON:0003889 ! part of fallopian tube [Term] id: UBERON:0011299 name: white matter of telencephalon def: "A partion of white matter that is part of a telencephalon. This can be further subdivided in some species, for example, into hemisphere white matter and the corpus callosum." [https://orcid.org/0000-0002-6601-2165] synonym: "predominantly white regional part of telencephalon" EXACT [BIRNLEX:1075] synonym: "telencephalic tract/commissure" EXACT [ZFA:0000597] synonym: "telencephalic tracts" NARROW [TAO:0000597] synonym: "telencephalic white matter" EXACT [HBA:TELWM] xref: BIRNLEX:1075 xref: FMA:83930 xref: HBA:9219 xref: HBA:9230 xref: TAO:0000597 xref: ZFA:0000597 is_a: UBERON:0019261 ! white matter of forebrain intersection_of: UBERON:0002316 ! white matter intersection_of: BFO:0000050 UBERON:0001893 ! part of telencephalon relationship: BFO:0000050 UBERON:0001893 ! part of telencephalon property_value: skos:prefLabel "white matter of telencephalon" xsd:string [Term] id: UBERON:0011300 name: gray matter of telencephalon def: "A portion of gray matter that is part of a telencephalon." [OBOL:automatic] synonym: "predominantly gray regional part of telencephalon" EXACT [BIRNLEX:1067] xref: BIRNLEX:1067 xref: FMA:83911 is_a: UBERON:0019264 ! gray matter of forebrain intersection_of: UBERON:0002020 ! gray matter intersection_of: BFO:0000050 UBERON:0001893 ! part of telencephalon relationship: BFO:0000050 UBERON:0001893 ! part of telencephalon property_value: skos:prefLabel "gray matter of telencephalon" xsd:string [Term] id: UBERON:0011332 name: extrinsic tongue pre-muscle mass xref: EMAPA:17884 is_a: UBERON:0005865 ! pre-muscle condensation intersection_of: UBERON:0005865 ! pre-muscle condensation intersection_of: RO:0002387 UBERON:0001575 ! has potential to develop into extrinsic muscle of tongue relationship: RO:0002387 UBERON:0001575 ! has potential to develop into extrinsic muscle of tongue property_value: skos:prefLabel "extrinsic tongue pre-muscle mass" xsd:string [Term] id: UBERON:0011357 name: Reissner's fiber def: "An acellular strand that runs from subcommissural organ caudally through the ventricular system and central canal to the ampulla caudalis. Develops from glycoproteins secreted into CSF." [ISBN:0471888893, Wikipedia:Reissner's_fiber] synonym: "Reissner's fibre" EXACT [] xref: NLX:151878 xref: Wikipedia:Reissner's_fiber is_a: UBERON:0000476 ! acellular anatomical structure relationship: BFO:0000050 UBERON:0001017 ! part of central nervous system relationship: RO:0002473 PR:000015658 ! composed primarily of SCO-spondin property_value: RO:0002175 NCBITaxon:7711 {source="ISBN:0471888893"} property_value: skos:prefLabel "Reissner's fiber" xsd:string [Term] id: UBERON:0011362 name: cranial blood vasculature def: "A blood vasculature that is part of a head." [OBOL:automatic] synonym: "cranial blood vessel" EXACT [ZFA:0005297] synonym: "cranial blood vessels" RELATED OMO:0003004 [TAO:0005297] synonym: "set of blood vessels of head" EXACT [] xref: TAO:0005297 xref: ZFA:0005297 is_a: UBERON:0002200 ! vasculature of head is_a: UBERON:0004537 ! blood vasculature intersection_of: UBERON:0004537 ! blood vasculature intersection_of: BFO:0000050 UBERON:0000033 ! part of head property_value: skos:prefLabel "cranial blood vasculature" xsd:string [Term] id: UBERON:0011363 name: cranial lymph vasculature def: "A lymph vasculature that is part of a head." [OBOL:automatic] synonym: "cranial lymph vessel" EXACT [ZFA:0005298] synonym: "cranial lymph vessels" RELATED OMO:0003004 [TAO:0005298] synonym: "cranial lymphatics" EXACT [UBERON:cjm] synonym: "set of cranial lymphatic vessels" RELATED [FMA:224562] synonym: "set of lymphatic vessels of head" EXACT [FMA:224562] xref: FMA:224562 xref: TAO:0005298 xref: ZFA:0005298 is_a: UBERON:0002200 ! vasculature of head is_a: UBERON:0004536 ! lymph vasculature intersection_of: UBERON:0004536 ! lymph vasculature intersection_of: BFO:0000050 UBERON:0000033 ! part of head [Term] id: UBERON:0011370 name: transverse process of atlas def: "A transverse process of vertebra that is part of a vertebral bone 1." [OBOL:automatic] xref: FMA:23981 xref: SCTID:181895009 xref: Wikipedia:Transverse_processes is_a: UBERON:0001077 ! transverse process of vertebra is_a: UBERON:0015212 ! lateral structure intersection_of: UBERON:0001077 ! transverse process of vertebra intersection_of: BFO:0000050 UBERON:0001092 ! part of vertebral bone 1 relationship: BFO:0000050 UBERON:0001092 ! part of vertebral bone 1 relationship: BSPO:0000126 UBERON:0001092 {source="FMA-abduced-lr"} ! vertebral bone 1 [Term] id: UBERON:0011374 name: prepuce def: "A retractable double-layered fold of skin and mucous membrane that covers the glans penis or clitoris. Glands may also be present." [http://orcid.org/0000-0002-6601-2165] xref: NCIT:C12323 is_a: UBERON:0005156 ! reproductive structure is_a: UBERON:0034929 ! external soft tissue zone relationship: BFO:0000050 UBERON:0003133 ! part of reproductive organ relationship: BFO:0000051 UBERON:0000344 ! has part mucosa relationship: RO:0002494 UBERON:0035004 ! transformation of preputial swelling [Term] id: UBERON:0011375 name: skin of prepuce of clitoris def: "A zone of skin that is part of a prepuce of clitoris." [OBOL:automatic] synonym: "preputial skin of clitoris" EXACT [FMA:27886] xref: FMA:27886 xref: SCTID:367670008 is_a: UBERON:0005298 ! skin of clitoris intersection_of: UBERON:0000014 ! zone of skin intersection_of: BFO:0000050 UBERON:0005299 ! part of prepuce of clitoris relationship: BFO:0000050 UBERON:0005298 ! part of skin of clitoris relationship: BFO:0000050 UBERON:0005299 ! part of prepuce of clitoris [Term] id: UBERON:0011565 name: lumen of gastrointestinal system synonym: "cavity of digestive tract" EXACT [] synonym: "cavity of gastrointestinal tract" EXACT [] synonym: "gastrointestinal tract lumen" EXACT [FMA:54364] synonym: "lumen of gastrointestinal tract" EXACT [FMA:54364] xref: FMA:54364 xref: SCTID:432899004 is_a: UBERON:0002553 ! anatomical cavity relationship: BFO:0000050 UBERON:0001007 ! part of digestive system property_value: skos:prefLabel "lumen of gastrointestinal system" xsd:string [Term] id: UBERON:0011566 name: lumen of esophagus def: "An anatomical cavity that is part of a esophagus." [OBOL:automatic] subset: pheno_slim synonym: "cavity of eosophagus" EXACT [] synonym: "cavity of esophagus" EXACT [FMA:9398] synonym: "eosophageal cavity" EXACT [] synonym: "eosophageal lumen" EXACT [] synonym: "eosophagus lumen" EXACT [] synonym: "esophageal cavity" EXACT [FMA:9398] synonym: "esophageal lumen" EXACT [FMA:9398] synonym: "esophagus lumen" EXACT [FMA:9398] xref: EMAPA:18380 xref: FMA:9398 xref: SCTID:322648002 is_a: UBERON:0000464 ! anatomical space intersection_of: UBERON:0000464 ! anatomical space intersection_of: RO:0002572 UBERON:0001043 ! luminal space of esophagus relationship: BFO:0000050 UBERON:0011565 {source="FMA"} ! part of lumen of gastrointestinal system relationship: RO:0002572 UBERON:0001043 ! luminal space of esophagus property_value: skos:prefLabel "lumen of esophagus" xsd:string [Term] id: UBERON:0011574 name: mesonephric duct lumen def: "A tube lumen that is part of a mesonephric duct." [OBOL:automatic] synonym: "cavity of nephric duct" RELATED [] synonym: "nephric duct lumen" EXACT [EHDAA2:0001244] xref: EHDAA2:0001244 is_a: UBERON:0005082 ! tube lumen intersection_of: UBERON:0005082 ! tube lumen intersection_of: RO:0002572 UBERON:0003074 ! luminal space of mesonephric duct relationship: RO:0002572 UBERON:0003074 ! luminal space of mesonephric duct [Term] id: UBERON:0011582 name: paired limb/fin skeleton def: "The collection of all skeletal elements in an individual limb or fin." [https://orcid.org/0000-0002-6601-2165] subset: homology_grouping synonym: "limb/fin skeleton" EXACT [VSAO:0000301] synonym: "skeletal parts of limb/fin" EXACT [] synonym: "skeleton of limb/fin" EXACT [] xref: VSAO:0000301 is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0010912 ! subdivision of skeleton intersection_of: UBERON:0010912 ! subdivision of skeleton intersection_of: RO:0002576 UBERON:0004708 ! skeleton of paired limb/fin relationship: BFO:0000050 UBERON:0002091 ! part of appendicular skeleton relationship: RO:0002202 UBERON:0003081 {source="ISBN:9780878932504"} ! develops from lateral plate mesoderm relationship: RO:0002576 UBERON:0004708 ! skeleton of paired limb/fin property_value: skos:prefLabel "paired limb/fin skeleton" xsd:string [Term] id: UBERON:0011583 name: stylopodial skeleton def: "Proximal element of a free limb skeleton consisting of the femur and humerus in the forelimb stylopodium and hindlimb stylopodium respectively[VSAO, modified]." [VSAO:0005007] synonym: "mesomere 1" RELATED HOMOLOGY [ISBN:0226313409] synonym: "propodial skeleton" RELATED [] synonym: "propodium" RELATED [VSAO:0005007] synonym: "proximal metapterygial mesomere" RELATED HOMOLOGY [ISBN:0226313409] synonym: "stylopod" RELATED [VSAO:0005007] synonym: "stylopodium" RELATED [] synonym: "stylopodium skeleton" EXACT [] xref: VSAO:0005007 is_a: UBERON:0010712 ! limb skeleton subdivision intersection_of: UBERON:0010912 ! subdivision of skeleton intersection_of: RO:0002576 UBERON:0002472 ! skeleton of stylopod relationship: BFO:0000050 UBERON:0004381 {source="VSAO"} ! part of skeleton of limb relationship: RO:0002576 UBERON:0002472 ! skeleton of stylopod [Term] id: UBERON:0011584 name: zeugopodial skeleton def: "Section of the forelimb skeleton located between the stylopodium and the autopodium." [VSAO:0005010] synonym: "epipodial skeleton" EXACT [] synonym: "epipodium" RELATED [VSAO:0005010] synonym: "mesomere 2" RELATED HOMOLOGY [ISBN:0226313409] synonym: "mesomere 2 skeleton" RELATED HOMOLOGY [ISBN:0226313409] synonym: "skeleton of zeugopod" EXACT [https://orcid.org/0000-0002-6601-2165] synonym: "zeugopod skeleton" EXACT [https://orcid.org/0000-0002-6601-2165] synonym: "zygopodium" RELATED [VSAO:0005010] xref: VSAO:0005010 is_a: UBERON:0010712 ! limb skeleton subdivision intersection_of: UBERON:0010912 ! subdivision of skeleton intersection_of: RO:0002576 UBERON:0002471 ! skeleton of zeugopod relationship: BFO:0000050 UBERON:0004381 {source="VSAO"} ! part of skeleton of limb relationship: proximally_connected_to UBERON:0011583 ! stylopodial skeleton relationship: RO:0002576 UBERON:0002471 ! skeleton of zeugopod [Term] id: UBERON:0011585 name: cell condensation def: "Anatomical structure that is an aggregation of similar cells from which cartilages and bones form, and from which chondrogenesis and osteogenesis are initiated during repair and/or regeneration. (Hall and Miyake 1995)." [GO_REF:0000034, http://dx.plos.org/10.1371/journal.pone.0051070, PSPUB:0000170, VSAO:0000006] xref: VSAO:0000006 xref: XAO:0004021 is_a: UBERON:0000061 {source="VSAO"} ! anatomical structure property_value: IAO:0000116 "consider obsoleting, coordinate with VSAO" xsd:string property_value: skos:prefLabel "cell condensation" xsd:string [Term] id: UBERON:0011587 name: pre-dentine def: "Odontogenic tissue that is collagen-rich and characteristic of vertebrate teeth and tooth-like structures (e.g., odontodes) deposited by preodontoblasts and odontoblasts that are typically excluded from the matrix." [GO_REF:0000034, http://dx.plos.org/10.1371/journal.pone.0051070, PSPUB:0000170, VSAO:0000071] synonym: "pre-dentine tissue" EXACT [VSAO:curator] synonym: "predentin" EXACT [PMCID:PMC3360947] synonym: "predentine tissue" EXACT [VSAO:curator] xref: EMAPA:36439 xref: VSAO:0000071 xref: XAO:0004052 is_a: UBERON:0010313 ! neural crest-derived structure is_a: UBERON:0010365 {source="VSAO"} ! odontoid tissue relationship: RO:0003001 CL:0000060 {source="text definition"} ! produced by odontoblast [Term] id: UBERON:0011588 name: pre-enamel def: "Odontogenic tissue that is avascular non-mineralized matrix that is deposited by preameloblast and ameloblasts that are excluded from the matrix." [GO_REF:0000034, http://dx.plos.org/10.1371/journal.pone.0051070, PSPUB:0000170, VSAO:0000066] synonym: "pre-enamel tissue" EXACT [VSAO:curator] synonym: "preenamel tissue" EXACT [VSAO:curator] xref: VSAO:0000066 xref: XAO:0004202 is_a: UBERON:0010365 {source="VSAO"} ! odontoid tissue relationship: RO:0003001 CL:0000059 ! produced by ameloblast [Term] id: UBERON:0011589 name: non-mineralized cartilage tissue def: "Cartilage tissue that is not mineralized." [GO_REF:0000034, http://dx.plos.org/10.1371/journal.pone.0051070, PSPUB:0000170, VSAO:0000089] xref: VSAO:0000089 xref: XAO:0004044 is_a: UBERON:0002418 {source="VSAO"} ! cartilage tissue property_value: IAO:0000116 "add developmental relationships; add disjointness axiom" xsd:string [Term] id: UBERON:0011590 name: commissure of diencephalon def: "A commissure that is part of a diencephalon." [OBOL:automatic] synonym: "diencephalon commissure" EXACT [FMA:62445] xref: FMA:62445 is_a: UBERON:0005970 ! brain commissure is_a: UBERON:0011591 ! tract of diencephalon intersection_of: UBERON:0001020 ! nervous system commissure intersection_of: BFO:0000050 UBERON:0001894 ! part of diencephalon property_value: skos:prefLabel "commissure of diencephalon" xsd:string [Term] id: UBERON:0011591 name: tract of diencephalon def: "An axon tract that is part of a diencephalon." [OBOL:automatic] synonym: "diencephalon tract" EXACT [FMA:62447] xref: FMA:62447 is_a: UBERON:0007702 ! tract of brain intersection_of: UBERON:0001018 ! axon tract intersection_of: BFO:0000050 UBERON:0001894 ! part of diencephalon relationship: BFO:0000050 UBERON:0001894 ! part of diencephalon property_value: skos:prefLabel "tract of diencephalon" xsd:string [Term] id: UBERON:0011592 name: future upper lip synonym: "upper jaw future lip" EXACT [EHDAA2:0002120] xref: EHDAA2:0002120 is_a: BFO:0000002 is_a: UBERON:0000490 {source="EHDAA2"} ! unilaminar epithelium is_a: UBERON:0003235 ! epithelium of upper jaw relationship: RO:0002202 UBERON:0004068 ! develops from medial nasal prominence relationship: RO:0002202 UBERON:0005868 ! develops from maxillary prominence property_value: skos:prefLabel "future upper lip" xsd:string [Term] id: UBERON:0011594 name: dentary tooth def: "Tooth that is attached to a dentary/mandible[TAO,modified]." [TAO:0001628] synonym: "mandibular teeth" RELATED OMO:0003004 [AAO:0000641] synonym: "mandibular tooth" RELATED [] synonym: "tooth of dentary" RELATED [] xref: AAO:0000125 xref: AAO:0000641 xref: SCTID:245547003 xref: TAO:0001628 is_a: UBERON:0003268 ! tooth of lower jaw intersection_of: UBERON:0001091 ! calcareous tooth intersection_of: RO:0002371 UBERON:0004742 ! attached to dentary relationship: RO:0002371 UBERON:0004742 ! attached to dentary property_value: IAO:0000116 "Note that we treat dentary tooth and mandibular tooth as equivalent" xsd:string [Term] id: UBERON:0011595 name: jaw region def: "A subdivision of the head that corresponds to the jaw skeleton, containing both soft tissue, skeleton and teeth (when present). The jaw region is divided into upper and lower regions." [http://orcid.org/0000-0002-6601-2165] xref: EMAPA:32905 xref: NCIT:C114916 is_a: UBERON:0000475 ! organism subdivision is_a: UBERON:0010314 ! structure with developmental contribution from neural crest intersection_of: UBERON:0000475 ! organism subdivision intersection_of: RO:0002551 UBERON:0001708 ! has skeleton jaw skeleton relationship: BFO:0000050 UBERON:0000165 {source="EMAPA", source="FMA-abduced", source="ZFA-abduced"} ! part of mouth relationship: RO:0002551 UBERON:0001708 ! has skeleton jaw skeleton property_value: seeAlso "http://eol.org/collections/11578" xsd:anyURI property_value: skos:prefLabel "jaw region" xsd:string [Term] id: UBERON:0011596 name: future lower lip synonym: "lower jaw future lip" EXACT [EHDAA2:0001020] xref: EHDAA2:0001020 is_a: BFO:0000002 is_a: UBERON:0000490 {source="EHDAA2"} ! unilaminar epithelium is_a: UBERON:0003236 ! epithelium of lower jaw relationship: RO:0002202 UBERON:0005867 {source="Wikipedia:Mandibular_prominence"} ! develops from mandibular prominence property_value: skos:prefLabel "future lower lip" xsd:string [Term] id: UBERON:0011597 name: bone of upper jaw def: "Any bone that is part of the upper jaw skeleton. This includes (when present): the maxilla, the quadrate (in some species)." [https://orcid.org/0000-0002-6601-2165] subset: grouping_class synonym: "upper jaw bone" EXACT [] is_a: UBERON:0012360 ! bone of jaw intersection_of: UBERON:0001474 ! bone element intersection_of: BFO:0000050 UBERON:0001709 ! part of upper jaw region relationship: BFO:0000050 UBERON:0003277 ! part of skeleton of upper jaw property_value: IAO:0000116 "Do not manually classify under here - bones are automatically classified" xsd:string property_value: skos:prefLabel "bone of upper jaw" xsd:string [Term] id: UBERON:0011601 name: gingiva of upper jaw def: "A gingiva that is part of a upper jaw region." [OBOL:automatic] subset: pheno_slim synonym: "gum of maxilla" EXACT [] synonym: "gum of upper jaw" EXACT [EMAPA:18970] synonym: "maxillary gum" RELATED [FMA:59763] synonym: "upper gingiva" EXACT [] synonym: "upper gum" RELATED [] synonym: "upper jaw gingiva" EXACT [FMA:59763] xref: EMAPA:18970 xref: FMA:59763 xref: NCIT:C54205 xref: SCTID:304703001 xref: UMLS:C0227121 is_a: UBERON:0001828 ! gingiva intersection_of: UBERON:0001828 ! gingiva intersection_of: BFO:0000050 UBERON:0001709 ! part of upper jaw region relationship: BFO:0000050 UBERON:0001709 ! part of upper jaw region property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/mouth-female/v1.0/assets/3d-vh-f-mouth.glb" xsd:anyURI property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/mouth-male/v1.0/assets/3d-vh-m-mouth.glb" xsd:anyURI [Term] id: UBERON:0011602 name: gingiva of lower jaw def: "A gingiva that is part of a lower jaw region." [OBOL:automatic] subset: pheno_slim synonym: "gum of lower jaw" EXACT [EMAPA:18967] synonym: "gum of mandible" EXACT [] synonym: "lower gingiva" EXACT [] synonym: "lower gum" RELATED [] synonym: "lower jaw gingiva" EXACT [FMA:59764] synonym: "lower jaw gum" RELATED [FMA:59764] synonym: "mandibular gum" RELATED [FMA:59764] xref: EMAPA:18967 xref: FMA:59764 xref: NCIT:C54204 xref: SCTID:304704007 xref: UMLS:C0227123 is_a: UBERON:0001828 ! gingiva intersection_of: UBERON:0001828 ! gingiva intersection_of: BFO:0000050 UBERON:0001710 ! part of lower jaw region relationship: BFO:0000050 UBERON:0001710 ! part of lower jaw region property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/mouth-female/v1.0/assets/3d-vh-f-mouth.glb" xsd:anyURI property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/mouth-male/v1.0/assets/3d-vh-m-mouth.glb" xsd:anyURI [Term] id: UBERON:0011642 name: oral epithelium from ectoderm def: "An epithelium that develops_from a ectoderm and is part of a oral epithelium." [OBOL:automatic] xref: EHDAA2:0004137 is_a: UBERON:0000490 {source="EHDAA2"} ! unilaminar epithelium is_a: UBERON:0002424 ! oral epithelium is_a: UBERON:0010371 ! ecto-epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: BFO:0000050 UBERON:0002424 ! part of oral epithelium intersection_of: RO:0002202 UBERON:0000924 ! develops from ectoderm relationship: BFO:0000050 UBERON:0002424 ! part of oral epithelium relationship: RO:0002202 UBERON:0009479 {source="EHDAA2"} ! develops from ectoderm of buccopharyngeal membrane property_value: skos:prefLabel "oral epithelium from ectoderm" xsd:string [Term] id: UBERON:0011645 name: iliofemoralis muscle def: "Limb extensor that runs from ilium to femur." [ISBN:0073040584] synonym: "iliofemoralis" EXACT [] is_a: UBERON:0001325 ! muscle of pelvis intersection_of: UBERON:0001325 ! muscle of pelvis intersection_of: RO:0002372 UBERON:0001273 ! has muscle origin ilium intersection_of: RO:0002373 UBERON:0000981 ! has muscle insertion femur relationship: RO:0002372 UBERON:0001273 ! has muscle origin ilium relationship: RO:0002373 UBERON:0000981 ! has muscle insertion femur [Term] id: UBERON:0011648 name: jaw muscle subset: efo_slim subset: pheno_slim synonym: "mandibular muscle" EXACT [TAO:0000236] synonym: "mandibular muscles" EXACT OMO:0003004 [TAO:0000236] xref: AAO:0000247 xref: EFO:0003511 xref: TAO:0000236 xref: XAO:0003269 xref: ZFA:0000236 is_a: UBERON:0002376 ! cranial muscle relationship: RO:0002216 GO:0071626 ! capable of part of mastication property_value: skos:prefLabel "jaw muscle" xsd:string [Term] id: UBERON:0011676 name: subdivision of organism along main body axis def: "A major subdivision of an organism that divides an organism along its main body axis (typically anterio-posterior axis). In vertebrates, this is based on the vertebral column." [https://orcid.org/0000-0002-6601-2165] subset: upper_level synonym: "axial subdivision of organism" EXACT [] synonym: "body segment" RELATED [] synonym: "main body segment" RELATED [] xref: FBbt:00057001 {sssom:mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"} is_a: UBERON:0000475 ! organism subdivision relationship: BFO:0000050 UBERON:0013701 ! part of main body axis property_value: IAO:0000116 "Ideally this would be disjoint with analagous class for appendicular axes, but currently 'appendages' like antennae, horns cause a problem" xsd:string property_value: skos:prefLabel "subdivision of organism along main body axis" xsd:string [Term] id: UBERON:0011677 name: trunk vertebra def: "A vertebra in the trunk region. For tetrapods, includes lumbar and thoracic vertebrae. Excludes caudal/coccygeal vertebra, which are located posteriorly. In tetrapods this includes thoracic, lumbar and sacral vertebrae, and excludes the cervical vertebrae, which are located anteriorly." [UBERONREF:0000006] subset: pheno_slim synonym: "presacral vertebra" RELATED [http://orcid.org/0000-0002-6601-2165] synonym: "thoracolumbar vertebra" EXACT [] is_a: UBERON:0003463 ! trunk bone is_a: UBERON:0004451 {is_inferred="true"} ! trunk or cervical vertebra intersection_of: UBERON:0002412 ! vertebra intersection_of: BFO:0000050 UBERON:0009568 ! part of trunk region of vertebral column relationship: BFO:0000050 UBERON:0009568 ! part of trunk region of vertebral column property_value: skos:prefLabel "trunk vertebra" xsd:string [Term] id: UBERON:0011679 name: proximal tarsal bone def: "A tarsal bone that connected_to a hindlimb zeugopod skeleton." [OBOL:automatic] is_a: UBERON:0001447 ! tarsal bone is_a: UBERON:0014395 ! proximal mesopodial bone is_a: UBERON:0015081 ! proximal tarsal endochondral element intersection_of: UBERON:0015081 ! proximal tarsal endochondral element intersection_of: RO:0002473 UBERON:0002481 ! composed primarily of bone tissue relationship: RO:0002202 UBERON:0015082 ! develops from proximal tarsal cartilage [Term] id: UBERON:0011693 name: extraembryonic portion of umbilical artery synonym: "extraembryonic umbilical artery" EXACT [VHOG:0001157] xref: VHOG:0001157 is_a: UBERON:0000478 {source="EHDAA2-abduced"} ! extraembryonic structure is_a: UBERON:0001637 ! artery relationship: BFO:0000050 UBERON:0001310 ! part of umbilical artery relationship: BFO:0000050 UBERON:0007807 {source="EHDAA2-abduced"} ! part of connecting stalk vasculature relationship: RO:0002252 UBERON:0001309 {source="FMA"} ! connecting branch of internal iliac artery [Term] id: UBERON:0011695 name: embryonic cardiovascular system def: "A cardiovascular system that is part of a conceptus." [OBOL:automatic] synonym: "conceptus cardiovascular system" EXACT [] synonym: "embryonic circulatory system" RELATED [] synonym: "fetal circulatory system" RELATED [] xref: EHDAA2:0000216 xref: FMA:305965 xref: NCIT:C34148 is_a: UBERON:0004535 ! cardiovascular system intersection_of: UBERON:0004535 ! cardiovascular system intersection_of: BFO:0000050 UBERON:0004716 ! part of conceptus relationship: BFO:0000050 UBERON:0004716 ! part of conceptus property_value: skos:prefLabel "embryonic cardiovascular system" xsd:string [Term] id: UBERON:0011696 name: left extraembryonic umbilical artery synonym: "extraembryonic umbilical artery left" EXACT [EHDAA2:0000937] xref: EHDAA2:0000937 is_a: UBERON:0011693 ! extraembryonic portion of umbilical artery relationship: RO:0002170 UBERON:0011695 ! connected to embryonic cardiovascular system [Term] id: UBERON:0011697 name: right extraembryonic umbilical artery synonym: "extraembryonic umbilical artery right" EXACT [EHDAA2:0001721] xref: EHDAA2:0001721 is_a: UBERON:0011693 ! extraembryonic portion of umbilical artery [Term] id: UBERON:0011757 name: differentiated genital tubercle synonym: "phallus" RELATED [Wikipedia:Primordial_phallus] synonym: "phallus primordialis" RELATED OMO:0003011 [Wikipedia:Primordial_phallus] synonym: "primordial phallus" RELATED [Wikipedia:Primordial_phallus] xref: NCIT:C34274 xref: UMLS:C1514448 {source="ncithesaurus:Primordial_Phallus"} xref: Wikipedia:Primordial_phallus is_a: BFO:0000002 is_a: UBERON:0005423 ! developing anatomical structure union_of: UBERON:0006233 ! female genital tubercle union_of: UBERON:0006261 ! male genital tubercle relationship: BFO:0000050 UBERON:0004176 ! part of external genitalia relationship: RO:0002202 UBERON:0005876 ! develops from undifferentiated genital tubercle [Term] id: UBERON:0011766 name: left recurrent laryngeal nerve synonym: "left recurrent laryngeal branch" EXACT [EMAPA:25350] synonym: "left recurrent laryngeal nerve" EXACT [FMA:14469] synonym: "vagus X nerve left recurrent laryngeal branch" EXACT [MA:0001107] xref: EMAPA:25350 xref: FMA:14469 xref: MA:0001107 xref: SCTID:280300006 is_a: UBERON:0003716 ! recurrent laryngeal nerve is_a: UBERON:0015212 ! lateral structure intersection_of: UBERON:0003716 ! recurrent laryngeal nerve intersection_of: BSPO:0000120 UBERON:0000468 ! multicellular organism relationship: BSPO:0000120 UBERON:0000468 ! multicellular organism property_value: foaf:depiction "https://upload.wikimedia.org/wikipedia/commons/6/64/Recurrent_laryngeal_nerve.svg" xsd:anyURI property_value: skos:prefLabel "left recurrent laryngeal nerve" xsd:string [Term] id: UBERON:0011767 name: right recurrent laryngeal nerve synonym: "right recurrent laryngeal branch" EXACT [EMAPA:17275] synonym: "right recurrent laryngeal nerve" EXACT [FMA:14468] synonym: "vagus X nerve right recurrent laryngeal branch" EXACT [MA:0001108] xref: EMAPA:17275 xref: FMA:14468 xref: MA:0001108 xref: SCTID:280299003 is_a: UBERON:0003716 ! recurrent laryngeal nerve is_a: UBERON:0015212 ! lateral structure intersection_of: UBERON:0003716 ! recurrent laryngeal nerve intersection_of: BSPO:0000121 UBERON:0000468 ! multicellular organism relationship: BSPO:0000121 UBERON:0000468 ! multicellular organism property_value: skos:prefLabel "right recurrent laryngeal nerve" xsd:string [Term] id: UBERON:0011769 name: cartilaginous projection def: "Anatomical projection that is composed of cartilage tissue." [VSAO:wd] synonym: "cartilage process" EXACT [] synonym: "cartilaginous process" EXACT [] xref: FMA:284626 is_a: BFO:0000002 is_a: UBERON:0004529 ! anatomical projection intersection_of: UBERON:0004529 ! anatomical projection intersection_of: RO:0002473 UBERON:0002418 ! composed primarily of cartilage tissue relationship: RO:0002473 UBERON:0002418 ! composed primarily of cartilage tissue [Term] id: UBERON:0011772 name: lower jaw opening def: "An anatomical space that is part of a bone of lower jaw." [OBOL:automatic] xref: AAO:0000273 is_a: UBERON:0000464 ! anatomical space intersection_of: UBERON:0000464 ! anatomical space intersection_of: RO:0002572 UBERON:0004768 ! luminal space of bone of lower jaw relationship: RO:0002572 UBERON:0004768 ! luminal space of bone of lower jaw property_value: skos:prefLabel "lower jaw opening" xsd:string [Term] id: UBERON:0011773 name: upper jaw opening def: "An anatomical space that is part of a bone of upper jaw." [OBOL:automatic] xref: AAO:0000621 is_a: UBERON:0000464 ! anatomical space intersection_of: UBERON:0000464 ! anatomical space intersection_of: RO:0002572 UBERON:0011597 ! luminal space of bone of upper jaw relationship: RO:0002572 UBERON:0011597 ! luminal space of bone of upper jaw property_value: skos:prefLabel "upper jaw opening" xsd:string [Term] id: UBERON:0011775 name: vagus nerve nucleus def: "A cranial nerve nucleus that is associated with a vagus nerve." [OBOL:automatic] synonym: "nodosal nucleus" RELATED [http://orcid.org/0000-0002-6601-2165] synonym: "nucleus of vagal nerve" EXACT [] synonym: "nucleus of vagal X nerve" EXACT [] synonym: "nucleus of vagus nerve" EXACT [FMA:54573] synonym: "nucleus of Xth nerve" EXACT [] synonym: "tenth cranial nerve nucleus" EXACT [FMA:54573] synonym: "vagal nucleus" EXACT [http://orcid.org/0000-0002-6601-2165] synonym: "vagal X nucleus" EXACT [http://orcid.org/0000-0002-6601-2165] synonym: "vagus nucleus" EXACT [http://orcid.org/0000-0002-6601-2165] xref: FMA:54573 xref: SCTID:362467005 is_a: UBERON:0000126 ! cranial nerve nucleus is_a: UBERON:0009662 ! hindbrain nucleus intersection_of: UBERON:0000126 ! cranial nerve nucleus intersection_of: extends_fibers_into UBERON:0001759 ! vagus nerve relationship: extends_fibers_into UBERON:0001759 ! vagus nerve property_value: skos:prefLabel "vagus nerve nucleus" xsd:string [Term] id: UBERON:0011777 name: nucleus of spinal cord def: "A neural nucleus that is part of the spinal cord." [http://orcid.org/0000-0002-6601-2165] subset: grouping_class synonym: "spinal cord nucleus" EXACT [FMA:77011] xref: FMA:77011 is_a: UBERON:0000125 ! neural nucleus intersection_of: UBERON:0000125 ! neural nucleus intersection_of: BFO:0000050 UBERON:0002240 ! part of spinal cord relationship: BFO:0000050 UBERON:0002240 ! part of spinal cord property_value: skos:prefLabel "nucleus of spinal cord" xsd:string [Term] id: UBERON:0011779 name: nerve of head region def: "A nerve that is part of a head." [OBOL:automatic] subset: grouping_class synonym: "cephalic nerve" RELATED [] synonym: "head nerve" RELATED [] is_a: UBERON:0001021 ! nerve intersection_of: UBERON:0001021 ! nerve intersection_of: BFO:0000050 UBERON:0000033 ! part of head relationship: BFO:0000050 UBERON:0000033 ! part of head property_value: skos:prefLabel "nerve of head region" xsd:string [Term] id: UBERON:0011814 name: non-neurogenic ectodermal placode def: "Ectodermal placode that does not develop into a component of the nervous system." [http://orcid.org/0000-0002-6601-2165, PMID:11523831] is_a: UBERON:0005085 {source="cjm"} ! ectodermal placode property_value: skos:prefLabel "non-neurogenic ectodermal placode" xsd:string [Term] id: UBERON:0011817 name: skin appendage placode def: "An ectodermal placode that gives rise to any of the cutaneous appendages that protrude from the skin epidermis (heair, feathers, epidermal scales)." [https://github.com/obophenotype/uberon/issues/1266] synonym: "cutaneous appendage follicle placode" EXACT [] synonym: "skin follicle placode" EXACT [] is_a: BFO:0000002 is_a: UBERON:0006598 ! presumptive structure is_a: UBERON:0011814 {source="NCBIBook:NBK53175"} ! non-neurogenic ectodermal placode intersection_of: UBERON:0005085 ! ectodermal placode intersection_of: RO:0002387 UBERON:0036150 ! has potential to develop into skin appendage follicle relationship: RO:0002254 UBERON:0001003 ! has developmental contribution from skin epidermis relationship: RO:0002254 UBERON:0002067 ! has developmental contribution from dermis relationship: RO:0002387 UBERON:0036150 ! has potential to develop into skin appendage follicle [Term] id: UBERON:0011820 name: atrioventricular region def: "An anatomical junction that divides and overlaps with and atrium and a ventricle in the heart." [http://orcid.org/0000-0002-6601-2165] subset: human_reference_atlas synonym: "atrial ventricular junction" RELATED [GO:0003294] synonym: "atrioventricular junction" RELATED [FMA:85125, GO:0003294] synonym: "atrioventricular segment" RELATED [PMID:21234997] synonym: "AV region" RELATED [PMID:21234997] synonym: "AV segment" RELATED [PMID:21234997] xref: EHDAA2:0004149 xref: FMA:85125 is_a: UBERON:0007651 ! anatomical junction intersection_of: UBERON:0007651 ! anatomical junction intersection_of: BFO:0000050 UBERON:0000948 ! part of heart intersection_of: RO:0002176 UBERON:0002081 ! connects cardiac atrium intersection_of: RO:0002176 UBERON:0002082 ! connects cardiac ventricle relationship: BFO:0000050 UBERON:0000948 ! part of heart relationship: RO:0002176 UBERON:0002081 ! connects cardiac atrium relationship: RO:0002176 UBERON:0002082 ! connects cardiac ventricle property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "atrioventricular region" xsd:string [Term] id: UBERON:0011821 name: irregular connective tissue def: "Connective tissue, which consists of a population of connective tissue cells, the intercellular matrix of which contains an irregular network of collagen and elastic fiber bundles. Examples: areolar tissue, mucoid tissue, connective tissue of peritoneum, connective tissue of fibrous pericardium." [FMA:20107] xref: FMA:20107 is_a: UBERON:0002384 {source="FMA"} ! connective tissue property_value: skos:prefLabel "irregular connective tissue" xsd:string [Term] id: UBERON:0011822 name: dense irregular connective tissue def: "Irregular connective tissue is an irregular connective tissue, the intercellular matrix of which contains a dense irregular network of collagen and elastic fiber bundles. Examples: connective tissue of peritoneum, connective tissue of fibrous pericardium." [FMA:20109, Wikipedia:Dense_irregular_connective_tissue] synonym: "irregular dense connective tissue" EXACT [] synonym: "typus irregularis (textus connectivus collagenosus compactus)" EXACT [FMA:20109] xref: FMA:20109 xref: NCIT:C32882 xref: UMLS:C0738366 {source="ncithesaurus:Irregular_Dense_Connective_Tissue"} xref: Wikipedia:Dense_irregular_connective_tissue is_a: UBERON:0011821 {source="FMA"} ! irregular connective tissue is_a: UBERON:0011823 ! dense connective tissue intersection_of: UBERON:0011821 ! irregular connective tissue intersection_of: BFO:0000051 GO:0071953 ! has part elastic fiber intersection_of: RO:0002473 UBERON:0011860 ! composed primarily of collection of collagen fibrils relationship: BFO:0000051 GO:0071953 ! has part elastic fiber property_value: skos:prefLabel "dense irregular connective tissue" xsd:string [Term] id: UBERON:0011823 name: dense connective tissue def: "Dense connective tissue is mainly composed of collagen type I. Crowded between the collagen fibers are rows of fibroblasts, fiber-forming cells, that manufacture the fibers. Dense connective tissue forms strong, rope-like structures such as tendons and ligaments. Tendons attach skeletal muscles to bones; ligaments connect bones to bones at joints. Ligaments are more stretchy and contain more elastic fibers than tendons. Dense connective tissue also make up the lower layers of the skin (dermis), where it is arranged in sheets." [Wikipedia:Dense_connective_tissue] xref: AAO:0000121 xref: NCIT:C32450 xref: UMLS:C1511770 {source="ncithesaurus:Dense_Connective_Tissue"} xref: Wikipedia:Dense_connective_tissue is_a: UBERON:0002384 ! connective tissue intersection_of: UBERON:0002384 ! connective tissue intersection_of: RO:0002473 UBERON:0011860 ! composed primarily of collection of collagen fibrils disjoint_from: UBERON:0011825 ! loose connective tissue relationship: RO:0002473 UBERON:0011860 ! composed primarily of collection of collagen fibrils property_value: IAO:0000116 "our OWL definition states that this is differentiated from other connective tissue types by virtue of the fact that the collage fiber component predominates, as opposed to cells and fluid." xsd:string property_value: skos:prefLabel "dense connective tissue" xsd:string [Term] id: UBERON:0011824 name: fibrous connective tissue xref: FMA:75634 xref: SCTID:363130003 is_a: UBERON:0011822 {source="FMA"} ! dense irregular connective tissue property_value: skos:prefLabel "fibrous connective tissue" xsd:string [Term] id: UBERON:0011825 name: loose connective tissue def: "Irregular connective tissue, the intercellular matrix of which contains a sparse irregular network of collagen and elastic fiber bundles. Examples: areolar tissue, neuroglial tissue, mucoid tissue." [FMA:19783] synonym: "textus connectivus collagenosus laxus" EXACT OMO:0003011 [FMA:19783, FMA:TA] synonym: "textus connectivus laxus" EXACT OMO:0003011 [FMA:19783, FMA:TA] xref: FMA:19783 xref: NCIT:C33007 xref: UMLS:C1253917 {source="ncithesaurus:Loose_Connective_Tissue"} xref: Wikipedia:Loose_connective_tissue is_a: UBERON:0011821 {source="FMA"} ! irregular connective tissue property_value: skos:prefLabel "loose connective tissue" xsd:string [Term] id: UBERON:0011845 name: duct of sebaceous gland def: "A duct that is part of a sebaceous gland." [OBOL:automatic] synonym: "sebaceous gland duct" EXACT [FMA:70947] xref: FMA:70947 xref: NCIT:C33520 is_a: UBERON:0000058 ! duct intersection_of: UBERON:0000058 ! duct intersection_of: BFO:0000050 UBERON:0001821 ! part of sebaceous gland relationship: BFO:0000050 UBERON:0001821 ! part of sebaceous gland [Term] id: UBERON:0011846 name: acinus of sebaceous gland def: "An acinus that is part of a sebaceous gland." [OBOL:automatic] synonym: "sebaceous gland acinus" EXACT [FMA:59657] xref: FMA:59657 is_a: UBERON:0011858 ! acinus of exocrine gland intersection_of: UBERON:0009842 ! glandular acinus intersection_of: BFO:0000050 UBERON:0001821 ! part of sebaceous gland relationship: BFO:0000050 UBERON:0001821 ! part of sebaceous gland [Term] id: UBERON:0011847 name: acinus of parotid gland def: "An acinus that is part of a parotid gland." [OBOL:automatic] subset: human_reference_atlas subset: pheno_slim synonym: "parotid gland acinus" EXACT [FMA:59863] xref: EMAPA:37933 {source="MA:th"} xref: FMA:59863 xref: SCTID:46926004 is_a: UBERON:0011850 ! acinus of salivary gland is_a: UBERON:0013232 ! serous acinus intersection_of: UBERON:0009842 ! glandular acinus intersection_of: BFO:0000050 UBERON:0001831 ! part of parotid gland relationship: BFO:0000050 UBERON:0001831 ! part of parotid gland property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0011850 name: acinus of salivary gland def: "An acinus that is part of a salivary gland." [OBOL:automatic] synonym: "salivary gland acinus" EXACT [FMA:59870] xref: FMA:59870 is_a: UBERON:0011858 ! acinus of exocrine gland intersection_of: UBERON:0009842 ! glandular acinus intersection_of: BFO:0000050 UBERON:0001044 ! part of saliva-secreting gland relationship: BFO:0000050 UBERON:0001044 ! part of saliva-secreting gland [Term] id: UBERON:0011856 name: acinus of lactiferous gland def: "An acinus that is part of a mammary gland." [OBOL:automatic] synonym: "lactiferous gland acinus" EXACT [FMA:74438] xref: FMA:74438 is_a: UBERON:0011858 ! acinus of exocrine gland intersection_of: UBERON:0009842 ! glandular acinus intersection_of: BFO:0000050 UBERON:0001911 ! part of mammary gland relationship: BFO:0000050 UBERON:0001912 ! part of lobule of mammary gland [Term] id: UBERON:0011857 name: acinus of lacrimal gland def: "An acinus that is part of a lacrimal gland." [OBOL:automatic] synonym: "lacrimal gland acinus" EXACT [FMA:85250] xref: FMA:85250 is_a: UBERON:0011858 ! acinus of exocrine gland intersection_of: UBERON:0009842 ! glandular acinus intersection_of: BFO:0000050 UBERON:0001817 ! part of lacrimal gland relationship: BFO:0000050 UBERON:0001817 ! part of lacrimal gland [Term] id: UBERON:0011858 name: acinus of exocrine gland def: "An acinus that is part of a exocrine gland." [OBOL:automatic] synonym: "exocrine gland acinus" EXACT [] is_a: UBERON:0009842 ! glandular acinus intersection_of: UBERON:0009842 ! glandular acinus intersection_of: BFO:0000050 UBERON:0002365 ! part of exocrine gland relationship: BFO:0000050 UBERON:0002365 ! part of exocrine gland property_value: skos:prefLabel "acinus of exocrine gland" xsd:string [Term] id: UBERON:0011860 name: collection of collagen fibrils xref: FMA:63212 xref: MESH:D024022 xref: NCIT:C32339 xref: NIF_Subcellular:sao7547390221 is_a: UBERON:0000476 {source="ZFA"} ! acellular anatomical structure relationship: RO:0002473 GO:0005581 ! composed primarily of collagen trimer relationship: RO:0002473 GO:0098643 ! composed primarily of fibrillar collagen property_value: seeAlso UBERON:0007377 property_value: skos:prefLabel "collection of collagen fibrils" xsd:string [Term] id: UBERON:0011861 name: aorta collagen fibril def: "The connective tissue bundles in the extracellular matrix of aorta tissue that are composed of collagen, and play a role in tissue strength and elasticity." [MP:0011640] subset: pheno_slim is_a: UBERON:0011860 ! collection of collagen fibrils intersection_of: UBERON:0011860 ! collection of collagen fibrils intersection_of: BFO:0000050 UBERON:0004664 ! part of aorta tunica adventitia relationship: BFO:0000050 UBERON:0004664 ! part of aorta tunica adventitia relationship: RO:0002433 UBERON:0004664 ! contributes to morphology of aorta tunica adventitia property_value: skos:prefLabel "aorta collagen fibril" xsd:string [Term] id: UBERON:0011862 name: pulmonary collagen fibril def: "The connective tissue bundles in the extracellular matrix of pulmonary tissue that are composed of collagen, and play a role in tissue strength and elasticity." [MP:0011641] subset: pheno_slim is_a: UBERON:0011860 ! collection of collagen fibrils intersection_of: UBERON:0011860 ! collection of collagen fibrils intersection_of: BFO:0000050 UBERON:0002048 ! part of lung relationship: BFO:0000050 UBERON:0002048 ! part of lung relationship: RO:0002433 UBERON:0002048 ! contributes to morphology of lung property_value: skos:prefLabel "pulmonary collagen fibril" xsd:string [Term] id: UBERON:0011863 name: bone collagen fibril def: "The connective tissue bundles in the extracellular matrix of bone tissue that are composed of collagen, and play a role in tissue strength and elasticity." [MP:0011642] subset: pheno_slim is_a: UBERON:0011860 ! collection of collagen fibrils intersection_of: UBERON:0011860 ! collection of collagen fibrils intersection_of: BFO:0000050 UBERON:0001474 ! part of bone element relationship: BFO:0000050 UBERON:0001474 ! part of bone element property_value: skos:prefLabel "bone collagen fibril" xsd:string [Term] id: UBERON:0011864 name: tendon collagen fibril def: "The connective tissue bundles in the extracellular matrix of tendon tissue that are composed of collagen, and play a role in tissue strength and elasticity." [MP:0011643] subset: pheno_slim is_a: UBERON:0011860 ! collection of collagen fibrils intersection_of: UBERON:0011860 ! collection of collagen fibrils intersection_of: BFO:0000050 UBERON:0000043 ! part of tendon relationship: BFO:0000050 UBERON:0000043 ! part of tendon relationship: RO:0002433 UBERON:0000043 ! contributes to morphology of tendon property_value: skos:prefLabel "tendon collagen fibril" xsd:string [Term] id: UBERON:0011865 name: corneal stroma collagen fibril def: "The connective tissue bundles in the extracellular matrix of corneal stroma that are composed of collagen, and play a role in tissue strength and elasticity." [MP:0011650] subset: pheno_slim is_a: UBERON:0011860 ! collection of collagen fibrils intersection_of: UBERON:0011860 ! collection of collagen fibrils intersection_of: BFO:0000050 UBERON:0001777 ! part of substantia propria of cornea relationship: BFO:0000050 UBERON:0001777 ! part of substantia propria of cornea relationship: RO:0002433 UBERON:0001777 ! contributes to morphology of substantia propria of cornea [Term] id: UBERON:0011875 name: ligament of sternoclavicular joint def: "A skeletal ligament that is part of a sternoclavicular joint." [OBOL:automatic] synonym: "ligamentum sternoclavicularis" EXACT OMO:0003011 [] synonym: "sternoclavicular joint ligament" EXACT [FMA:63980] xref: FMA:63980 xref: SCTID:182386007 is_a: UBERON:0008846 ! skeletal ligament intersection_of: UBERON:0008846 ! skeletal ligament intersection_of: BFO:0000050 UBERON:0001469 ! part of sternoclavicular joint relationship: BFO:0000050 UBERON:0001469 ! part of sternoclavicular joint [Term] id: UBERON:0011878 name: muscle layer of esophagus def: "A muscle layer that is part of a wall of esophagus." [OBOL:automatic] synonym: "muscle coat of esophagus" EXACT [FMA:62998] synonym: "muscular coat of oesophagus" EXACT [FMA:62998] synonym: "muscular layer of oesophagus" EXACT [FMA:62998] synonym: "tela muscularis (oesophagus)" EXACT OMO:0003011 [FMA:62998, FMA:TA] synonym: "tunica muscularis esophagi" EXACT OMO:0003011 [] synonym: "tunica muscularis oesophageae" EXACT OMO:0003011 [FMA:TA] xref: FMA:62998 is_a: UBERON:0018261 ! muscular coat of digestive tract intersection_of: UBERON:0006660 ! muscular coat intersection_of: BFO:0000050 UBERON:0001043 ! part of esophagus relationship: BFO:0000050 UBERON:0001096 ! part of wall of esophagus relationship: BFO:0000051 UBERON:0001134 ! has part skeletal muscle tissue property_value: skos:prefLabel "muscle layer of esophagus" xsd:string [Term] id: UBERON:0011892 name: anterior uvea def: "Front (ventral) portion of the vascular, pigmentary, or middle coat of the eye, including the ciliary body and the iris." [MP:0005194] subset: pheno_slim synonym: "anterior part of uveal tract" EXACT [] synonym: "anterior uveal tract" EXACT [] synonym: "anterior vascular layer of the eyeball" EXACT [] synonym: "anterior vascular tunic of the eye" EXACT [] synonym: "ciliary body and iris" RELATED [] synonym: "Haller tunica vascula" EXACT [MP:0005194] synonym: "tunica vasculosa bulbosa" EXACT [MP:0005194] synonym: "vasculosa oculi" RELATED [MP:0005194] synonym: "ventral uveal tract" EXACT [] xref: EMAPA:37417 {source="MA:th"} xref: SCTID:280656002 is_a: UBERON:0000481 {source="ZFA"} ! multi-tissue structure is_a: UBERON:0010314 ! structure with developmental contribution from neural crest relationship: BFO:0000050 UBERON:0001768 {source="MP"} ! part of uvea relationship: BFO:0000050 UBERON:0001801 ! part of anterior segment of eyeball relationship: BFO:0000051 UBERON:0001769 ! has part iris relationship: BFO:0000051 UBERON:0001775 ! has part ciliary body relationship: RO:0002433 UBERON:0001768 ! contributes to morphology of uvea relationship: RO:0002433 UBERON:0001801 ! contributes to morphology of anterior segment of eyeball property_value: skos:prefLabel "anterior uvea" xsd:string [Term] id: UBERON:0011894 name: lumen of vagina def: "An organ cavity that is part of a vagina." [OBOL:automatic] synonym: "vaginal lumen" EXACT [FMA:19982] xref: FMA:19982 is_a: UBERON:0002558 ! organ cavity intersection_of: UBERON:0002558 ! organ cavity intersection_of: BFO:0000050 UBERON:0000996 ! part of vagina relationship: BFO:0000050 UBERON:0000996 ! part of vagina [Term] id: UBERON:0011899 name: epimysium def: "Epimysium is a layer of connective tissue which ensheaths the entire muscle. It is composed of dense irregular connective tissue. It is continuous with fascia and other connective tissue wrappings of muscle including the endomysium, and perimysium. It is also continuous with tendons where it becomes thicker and collagenous." [Wikipedia:Epimysium] synonym: "epimysia" RELATED OMO:0003004 [Wikipedia:Epimysium] synonym: "fascia of muscle organ" EXACT [FMA:9726] xref: FMA:9726 xref: NCIT:C32527 xref: UMLS:C0504096 {source="ncithesaurus:Epimysium"} xref: Wikipedia:Epimysium is_a: UBERON:0011822 {source="FMA"} ! dense irregular connective tissue relationship: BFO:0000050 UBERON:0001134 {source="FMA"} ! part of skeletal muscle tissue relationship: RO:0002007 UBERON:0014892 ! bounding layer of skeletal muscle organ, vertebrate relationship: RO:0002150 UBERON:0000043 ! continuous with tendon property_value: skos:prefLabel "epimysium" xsd:string [Term] id: UBERON:0011919 name: yolk sac blood island def: "Masses of developing blood cells attached to endothelium in the yolk sac." [MP:0011204] subset: pheno_slim synonym: "visceral yolk sac blood island" EXACT [MP:0011204] synonym: "yolk sac blood islands" EXACT [EHDAA2:0000177] xref: EHDAA2:0000177 xref: EMAPA:16115 is_a: UBERON:0000478 ! extraembryonic structure is_a: UBERON:0003061 ! blood island intersection_of: UBERON:0003061 ! blood island intersection_of: BFO:0000050 UBERON:0003316 ! part of mesenchyme of yolk sac relationship: BFO:0000050 UBERON:0003316 ! part of mesenchyme of yolk sac relationship: RO:0002202 UBERON:0003316 {source="EHDAA2"} ! develops from mesenchyme of yolk sac property_value: skos:prefLabel "yolk sac blood island" xsd:string [Term] id: UBERON:0011921 name: connecting stalk blood islands synonym: "blood island of umbilical vesicle" EXACT [Wikipedia:Blood_island] synonym: "insula sanguinea vesiculae umbilicalis" EXACT [Wikipedia:Blood_island] xref: EHDAA2:0003242 is_a: UBERON:0007503 {source="EHDAA2"} ! epithelial vesicle is_a: UBERON:0010303 ! extraembryonic epithelium is_a: UBERON:0012275 ! meso-epithelium relationship: BFO:0000050 UBERON:0002331 {source="EHDAA2"} ! part of umbilical cord relationship: RO:0002202 UBERON:0005667 {source="EHDAA2"} ! develops from connecting stalk mesoderm [Term] id: UBERON:0011922 name: cochlear basement membrane def: "The the continuous basement membrane found within the membranous labyrinth of the cochlea, known to extend from the limbus, down to the inner sulcus, across the basilar membrane, up to the external sulcus to the spiral prominence and radiating into the spiral ligament ensheathing the root cell processes." [MP:0004598] subset: pheno_slim synonym: "basement membrane of cochlear labyrinth" EXACT [] synonym: "cochlea basement membrane" EXACT [] xref: EMAPA:37830 {source="MA:th"} is_a: UBERON:0005769 ! basement membrane of epithelium intersection_of: UBERON:0005769 ! basement membrane of epithelium intersection_of: BFO:0000050 UBERON:0002499 ! part of cochlear labyrinth relationship: BFO:0000050 UBERON:0002499 ! part of cochlear labyrinth [Term] id: UBERON:0011925 name: preganglionic autonomic fiber def: "Nerve fibers which project from the central nervous system to autonomic ganglia. In the sympathetic division most preganglionic fibers originate with neurons in the intermediolateral column of the spinal cord, exit via ventral roots from upper thoracic through lower lumbar segments, and project to the paravertebral ganglia; there they either terminate in synapses or continue through the splanchnic nerves to the prevertebral ganglia. In the parasympathetic division the fibers originate in neurons of the brain stem and sacral spinal cord. In both divisions the principal transmitter is acetylcholine but peptide cotransmitters may also be released." [MESH:A08.663.542.122, Wikipedia:Preganglionic_nerve_fibers] subset: human_reference_atlas synonym: "preganglionic autonomic fibre" RELATED [] synonym: "preganglionic nerve fiber" EXACT [FMA:5923] xref: FMA:5923 xref: MESH:D001339 xref: NCIT:C12624 xref: Wikipedia:Preganglionic_nerve_fibers is_a: UBERON:0003041 ! trigeminal nerve fibers intersection_of: UBERON:0006134 ! nerve fiber intersection_of: extends_fibers_into UBERON:0001017 ! central nervous system intersection_of: extends_fibers_into UBERON:0001805 ! autonomic ganglion relationship: BFO:0000050 UBERON:0034728 ! part of autonomic nerve relationship: extends_fibers_into UBERON:0001017 ! central nervous system relationship: extends_fibers_into UBERON:0001805 ! autonomic ganglion property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "preganglionic autonomic fiber" xsd:string [Term] id: UBERON:0011927 name: preganglionic sympathetic fiber def: "A cholinergic axonal fiber projecting from the CNS to a sympathetic ganglion." [MP:0008310] synonym: "sympathetic preganglionic fiber" RELATED [MP:0008310] xref: SCTID:323517007 is_a: UBERON:0011925 ! preganglionic autonomic fiber intersection_of: UBERON:0006134 ! nerve fiber intersection_of: extends_fibers_into UBERON:0001017 ! central nervous system intersection_of: extends_fibers_into UBERON:0001806 ! sympathetic ganglion relationship: BFO:0000050 UBERON:0034729 ! part of sympathetic nerve relationship: extends_fibers_into UBERON:0001806 ! sympathetic ganglion property_value: skos:prefLabel "preganglionic sympathetic fiber" xsd:string [Term] id: UBERON:0011930 name: preganglionic parasympathetic fiber def: "A cholinergic axonal fibers projecting from the CNS to a parasympathetic ganglion." [MP:0008311] synonym: "parasympathetic preganglionic fiber" RELATED [MP:0008311] xref: Wikipedia:Preganglionic_fibers is_a: UBERON:0011925 ! preganglionic autonomic fiber intersection_of: UBERON:0006134 ! nerve fiber intersection_of: extends_fibers_into UBERON:0001017 ! central nervous system intersection_of: extends_fibers_into UBERON:0001808 ! parasympathetic ganglion relationship: BFO:0000050 UBERON:0004293 ! part of parasympathetic nerve relationship: extends_fibers_into UBERON:0001808 ! parasympathetic ganglion property_value: skos:prefLabel "preganglionic parasympathetic fiber" xsd:string [Term] id: UBERON:0011931 name: nasal hair def: "Hair in the nose." [Wikipedia:Nasal_hair] subset: pheno_slim synonym: "hair of nose" EXACT [FMA:53670] synonym: "hair of vestibular part of nose" EXACT [FMA:53670] synonym: "nose hair" EXACT [FMA:53670] xref: FMA:53670 xref: SCTID:368885003 xref: Wikipedia:Nasal_hair is_a: UBERON:0010171 ! strand of hair of face intersection_of: UBERON:0001037 ! strand of hair intersection_of: BFO:0000050 UBERON:0000004 ! part of nose relationship: BFO:0000050 UBERON:0000004 ! part of nose [Term] id: UBERON:0011932 name: pilosebaceous unit def: "An epidermal invagination that has as parts a hair follicle, a sebaceous gland, and arrector pili muscle." [ISBN:0123813611, PMCID:PMC3130146, Wikipedia:Pilosebaceous_unit] subset: pheno_slim synonym: "fabrica pilosebacea" EXACT [Wikipedia:Pilosebaceous_unit] synonym: "pilo-sebaceous apparatus" EXACT [FMA:70661] synonym: "pilo-sebaceous unit" EXACT [] synonym: "pilosebaceous apparatus" EXACT [] synonym: "pilosebaceous gland" RELATED [FMA:70661] xref: EMAPA:36582 xref: FMA:70661 xref: Wikipedia:Pilosebaceous_unit is_a: BFO:0000002 is_a: UBERON:0000063 ! organ subunit relationship: BFO:0000050 UBERON:0006003 {source="ISBN:0123813611"} ! part of integumentary adnexa relationship: BFO:0000051 UBERON:0001821 ! has part sebaceous gland relationship: BFO:0000051 UBERON:0002033 ! has part arrector muscle of hair relationship: BFO:0000051 UBERON:0002073 ! has part hair follicle [Term] id: UBERON:0011945 name: luminal layer of epithelium subset: human_reference_atlas is_a: UBERON:0005162 ! multi cell part structure relationship: BFO:0000050 UBERON:0000483 ! part of epithelium property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0011947 name: ureter luminal urothelium def: "A luminal layer of epithelium that is part of a ureter." [OBOL:automatic] subset: pheno_slim xref: EMAPA:37779 {source="MA:th"} xref: MA:0002656 is_a: UBERON:0011945 ! luminal layer of epithelium intersection_of: UBERON:0011945 ! luminal layer of epithelium intersection_of: BFO:0000050 UBERON:0000056 ! part of ureter relationship: BFO:0000050 UBERON:0001254 ! part of urothelium of ureter [Term] id: UBERON:0011949 name: endometrium luminal epithelium def: "A luminal layer of epithelium that is part of a endometrium epithelium." [OBOL:automatic] subset: human_reference_atlas xref: EMAPA:35309 xref: MA:0002733 is_a: UBERON:0011945 ! luminal layer of epithelium intersection_of: UBERON:0011945 ! luminal layer of epithelium intersection_of: BFO:0000050 UBERON:0004811 ! part of endometrium epithelium relationship: BFO:0000050 UBERON:0004811 ! part of endometrium epithelium property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0011950 name: mammary gland luminal epithelium def: "The inner cell layer of the mammary epithelium bilayer that lines the luminal surface of mammary gland ducts and alveoli; luminal cells have only limited contact with the underlying basement membrane and surrounding connective tissue; they are secretory epithelial cells characterized by the expression of the receptors for systemic hormones, i.e. estrogens, progesterone and prolactin." [MGI:anna] synonym: "lumina layer of epithelium of lactiferous gland" EXACT [FMA:74458] xref: EMAPA:37902 {source="MA:th"} xref: FMA:74458 is_a: UBERON:0011945 ! luminal layer of epithelium intersection_of: UBERON:0011945 ! luminal layer of epithelium intersection_of: BFO:0000050 UBERON:0001911 ! part of mammary gland relationship: BFO:0000050 UBERON:0003244 {is_inferred="true", source="https://github.com/obophenotype/uberon/wiki/Inferring-part-of-relationships"} ! part of epithelium of mammary gland [Term] id: UBERON:0011951 name: prostate luminal epithelium def: "A luminal layer of epithelium that is part of a prostate gland." [OBOL:automatic] synonym: "subdivision of luminal layer of epithelium of prostatic gland" EXACT [FMA:74262] xref: FMA:74262 is_a: UBERON:0011945 ! luminal layer of epithelium intersection_of: UBERON:0011945 ! luminal layer of epithelium intersection_of: BFO:0000050 UBERON:0002367 ! part of prostate gland relationship: BFO:0000050 UBERON:0000428 {is_inferred="true", source="https://github.com/obophenotype/uberon/wiki/Inferring-part-of-relationships"} ! part of prostate epithelium [Term] id: UBERON:0011953 name: stomach glandular region def: "A region of the stomach that is lined with glandular epithelium." [http://orcid.org/0000-0002-6601-2165] subset: pheno_slim synonym: "glandular stomach" RELATED [] xref: EMAPA:17623 xref: MA:0001613 xref: NCIT:C77661 xref: SCTID:27633001 xref: UMLS:C0227197 {source="ncithesaurus:Glandular_Stomach"} is_a: UBERON:0009870 ! zone of stomach intersection_of: UBERON:0009870 ! zone of stomach intersection_of: BFO:0000051 UBERON:0006924 ! has part stomach glandular epithelium relationship: BFO:0000051 UBERON:0006924 ! has part stomach glandular epithelium property_value: IAO:0000116 "as currently defined, this would include the cardiac antrum; however, the intent may be to exclude the cardiac glands and in mice for this to be part of the region distal to the margo plicatus" xsd:string property_value: skos:prefLabel "stomach glandular region" xsd:string [Term] id: UBERON:0011955 name: left hepatic vein def: "A hepatic vein that is part of a left lobe of liver." [OBOL:automatic] subset: human_reference_atlas xref: EMAPA:37164 {source="MA:th"} xref: FMA:14339 xref: MA:0003032 xref: SCTID:55188000 is_a: UBERON:0001143 ! hepatic vein intersection_of: UBERON:0001143 ! hepatic vein intersection_of: BFO:0000050 UBERON:0001115 ! part of left lobe of liver relationship: BFO:0000050 UBERON:0001115 ! part of left lobe of liver property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "left hepatic vein" xsd:string [Term] id: UBERON:0011956 name: right hepatic vein def: "A hepatic vein that is part of a right lobe of liver." [OBOL:automatic] subset: human_reference_atlas xref: EMAPA:37377 {source="MA:th"} xref: FMA:14338 xref: MA:0003034 xref: SCTID:18135006 is_a: UBERON:0001143 ! hepatic vein intersection_of: UBERON:0001143 ! hepatic vein intersection_of: BFO:0000050 UBERON:0001114 ! part of right lobe of liver relationship: BFO:0000050 UBERON:0001114 ! part of right lobe of liver property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "right hepatic vein" xsd:string [Term] id: UBERON:0011960 name: articular capsule of glenohumeral joint def: "An articular capsule that is part of the glenohumeral joint." [http://orcid.org/0000-0002-6601-2165] synonym: "articular capsule of humerus" EXACT [Wikipedia:Articular_capsule_of_the_humerus] synonym: "articular capsule of shoulder joint" EXACT [] synonym: "capsule of shoulder joint" EXACT [FMA:34944] synonym: "fibrous capsule of glenohumeral joint" EXACT [FMA:34944] synonym: "glenohumeral joint capsule" RELATED [FMA:34944] xref: FMA:34944 xref: SCTID:361836001 xref: Wikipedia:Articular_capsule_of_the_humerus is_a: UBERON:0001484 ! articular capsule intersection_of: UBERON:0001484 ! articular capsule intersection_of: BFO:0000050 UBERON:0001470 ! part of glenohumeral joint relationship: BFO:0000050 UBERON:0001470 ! part of glenohumeral joint relationship: RO:0002221 UBERON:0001470 ! surrounds glenohumeral joint [Term] id: UBERON:0011965 name: saddle joint def: "In a saddle joint (sellar joint, articulation by reciprocal reception) the opposing surfaces are reciprocally concave-convex." [Wikipedia:Saddle_joint] synonym: "articulation by reciprocal reception" RELATED [Wikipedia:Saddle_joint] synonym: "sellar joint" EXACT [Wikipedia:Saddle_joint] xref: FMA:75298 xref: SCTID:23059003 xref: Wikipedia:Saddle_joint is_a: UBERON:0000982 ! skeletal joint [Term] id: UBERON:0011972 name: medial ligament of ankle joint def: "A skeletal ligament that connects a tibia and connects a tarsal skeleton." [OBOL:automatic] synonym: "deltoid collateral ligament of ankle joint" EXACT [FMA:44055] synonym: "deltoid ligament of ankle joint" EXACT [FMA:44055] synonym: "ligamentum collaterale mediale (articulatio talocruralis)" EXACT [FMA:44055] synonym: "ligamentum collaterale mediale articulationis talocruralis" EXACT OMO:0003011 [FMA:44055, FMA:TA] synonym: "ligamentum deltoideum" EXACT [FMA:TA] synonym: "ligamentum deltoideum (articulatio talocruralis)" EXACT [FMA:44055] synonym: "medial collateral ligament of ankle joint" EXACT [FMA:44055] xref: FMA:44055 xref: SCTID:41159004 is_a: UBERON:0008846 ! skeletal ligament intersection_of: UBERON:0008846 ! skeletal ligament intersection_of: RO:0002176 UBERON:0000979 ! connects tibia intersection_of: RO:0002176 UBERON:0009879 ! connects tarsal skeleton relationship: BFO:0000050 UBERON:0001488 ! part of ankle joint relationship: RO:0002176 UBERON:0000979 ! connects tibia relationship: RO:0002176 UBERON:0009879 ! connects tarsal skeleton [Term] id: UBERON:0011973 name: epiphysis of phalanx of pes def: "An epiphysis that is part of a phalanx of a pes [Automatically generated definition]." [OBOL:automatic] synonym: "epiphysis of phalanx of toe" EXACT [] xref: SCTID:314621001 is_a: UBERON:0001437 ! epiphysis intersection_of: UBERON:0001437 ! epiphysis intersection_of: BFO:0000050 UBERON:0002387 ! part of pes relationship: BFO:0000050 UBERON:0002387 ! part of pes [Term] id: UBERON:0011974 name: epiphysis of proximal phalanx of pes def: "An epiphysis that is part of a proximal phalanx of pes." [OBOL:automatic] synonym: "epiphysis of proximal phalanx of toe" EXACT [] xref: SCTID:280047006 is_a: UBERON:0004446 ! epiphysis of phalanx is_a: UBERON:0011973 ! epiphysis of phalanx of pes intersection_of: UBERON:0001437 ! epiphysis intersection_of: BFO:0000050 UBERON:0003868 ! part of proximal phalanx of pes relationship: BFO:0000050 UBERON:0003868 ! part of proximal phalanx of pes [Term] id: UBERON:0011975 name: epiphysis of middle phalanx of pes def: "An epiphysis that is part of a middle phalanx of pes." [OBOL:automatic] synonym: "epiphysis of middle phalanx of toe" EXACT [] xref: SCTID:280048001 is_a: UBERON:0004446 ! epiphysis of phalanx is_a: UBERON:0011973 ! epiphysis of phalanx of pes intersection_of: UBERON:0001437 ! epiphysis intersection_of: BFO:0000050 UBERON:0003866 ! part of middle phalanx of pes relationship: BFO:0000050 UBERON:0003866 ! part of middle phalanx of pes [Term] id: UBERON:0011976 name: epiphysis of distal phalanx of pes def: "An epiphysis that is part of a distal phalanx of pes." [OBOL:automatic] synonym: "epiphysis of distal phalanx of toe" EXACT [] xref: SCTID:280049009 is_a: UBERON:0004446 ! epiphysis of phalanx is_a: UBERON:0011973 ! epiphysis of phalanx of pes intersection_of: UBERON:0001437 ! epiphysis intersection_of: BFO:0000050 UBERON:0003867 ! part of distal phalanx of pes relationship: BFO:0000050 UBERON:0003867 ! part of distal phalanx of pes [Term] id: UBERON:0011977 name: epiphysis of proximal phalanx of manus def: "An epiphysis that is part of a proximal phalanx of manus." [OBOL:automatic] subset: pheno_slim synonym: "epiphysis of proximal phalanx of finger" EXACT [] xref: SCTID:280044004 is_a: UBERON:0004387 ! epiphysis of phalanx of manus intersection_of: UBERON:0001437 ! epiphysis intersection_of: BFO:0000050 UBERON:0002234 ! part of proximal phalanx of manus relationship: BFO:0000050 UBERON:0002234 ! part of proximal phalanx of manus [Term] id: UBERON:0011978 name: epiphysis of middle phalanx of manus def: "An epiphysis that is part of a middle phalanx of manus." [OBOL:automatic] synonym: "epiphysis of middle phalanx of finger" EXACT [] xref: SCTID:280045003 is_a: UBERON:0004387 ! epiphysis of phalanx of manus intersection_of: UBERON:0001437 ! epiphysis intersection_of: BFO:0000050 UBERON:0003864 ! part of middle phalanx of manus relationship: BFO:0000050 UBERON:0003864 ! part of middle phalanx of manus [Term] id: UBERON:0011979 name: epiphysis of distal phalanx of manus def: "An epiphysis that is part of a distal phalanx of manus." [OBOL:automatic] synonym: "epiphysis of distal phalanx of finger" EXACT [] xref: FMA:321561 xref: SCTID:280046002 is_a: UBERON:0004387 ! epiphysis of phalanx of manus intersection_of: UBERON:0001437 ! epiphysis intersection_of: BFO:0000050 UBERON:0003865 ! part of distal phalanx of manus relationship: BFO:0000050 UBERON:0003865 ! part of distal phalanx of manus [Term] id: UBERON:0011980 name: crurotarsal joint def: "A joint that connects the bones of the crus to the proximal tarsal bones." [Wikipedia:Crurotarsal] comment: line of flexion between calcaneus and astragalus synonym: "crurotarsal" RELATED [] xref: Wikipedia:Crurotarsal is_a: UBERON:0001488 ! ankle joint intersection_of: UBERON:0000982 ! skeletal joint intersection_of: RO:0002176 UBERON:0010720 ! connects hindlimb zeugopod skeleton intersection_of: RO:0002176 UBERON:0011679 ! connects proximal tarsal bone relationship: RO:0002176 UBERON:0011679 ! connects proximal tarsal bone [Term] id: UBERON:0011997 name: coelom def: "The aggregate of the coelemic cavity lumen plus the membranes that line the lumen." [UBERON:cjm, Wikipedia:Body_cavity, Wikipedia:Coelom] synonym: "coelem" RELATED [] synonym: "coelomic cavity" RELATED [EHDAA2:0004731] synonym: "enterocoelom" NARROW [NCBITaxon:33511] synonym: "haemocoelom" NARROW [] synonym: "schizocoelom" NARROW [] xref: EHDAA2:0004731 xref: Wikipedia:Coelom xref: ZFA:0001438 is_a: UBERON:0000481 {source="EHDAA2"} ! multi-tissue structure relationship: RO:0002162 NCBITaxon:33213 ! in taxon Bilateria property_value: IAO:0000116 "EHDAA2 distingsuishes between the lumen, the lining, and the 'coelomic cavity', which despire it's name, is not a space - it is the aggregate of space plus lining." xsd:string property_value: RO:0002161 NCBITaxon:147099 {source="Wikipedia:Acoelomorpha"} property_value: skos:prefLabel "coelom" xsd:string [Term] id: UBERON:0012054 name: myocoele def: "The cavity within a myotome." [http://medical-dictionary.thefreedictionary.com/myocoele] xref: EMAPA:31134 xref: VHOG:0001283 is_a: UBERON:0002553 ! anatomical cavity intersection_of: UBERON:0002553 ! anatomical cavity intersection_of: RO:0002572 UBERON:0003082 ! luminal space of myotome relationship: RO:0002572 UBERON:0003082 ! luminal space of myotome property_value: skos:prefLabel "myocoele" xsd:string [Term] id: UBERON:0012069 name: epithelium-associated lymphoid tissue xref: FMA:62811 is_a: UBERON:0001744 {source="FMA"} ! lymphoid tissue [Term] id: UBERON:0012070 name: palatal tooth def: "A tooth that is on the roof of the mouth." [http://palaeos.com/vertebrates/therapsida/anteosauria.html] synonym: "palatal teeth" EXACT OMO:0003004 [] is_a: UBERON:0003267 ! tooth of upper jaw intersection_of: UBERON:0001091 ! calcareous tooth intersection_of: RO:0002371 UBERON:0012071 ! attached to palate bone relationship: RO:0002371 UBERON:0012071 ! attached to palate bone [Term] id: UBERON:0012071 name: palate bone def: "Any bone that is part of a palate." [https://orcid.org/0000-0002-6601-2165] subset: pheno_slim synonym: "palatal bone" EXACT [] xref: EMAPA:37930 {source="MA:th"} xref: NCIT:C33248 xref: UMLS:C1518857 {source="ncithesaurus:Palate_Bone"} is_a: UBERON:0003457 ! head bone is_a: UBERON:0008907 ! dermal bone intersection_of: UBERON:0001474 ! bone element intersection_of: BFO:0000050 UBERON:0007375 ! part of roof of mouth relationship: BFO:0000050 UBERON:0012072 ! part of palatal part of dermatocranium property_value: skos:prefLabel "palate bone" xsd:string [Term] id: UBERON:0012072 name: palatal part of dermatocranium synonym: "dermatocranium, palatal series" RELATED [ISBN:0073040584] synonym: "palatal series" RELATED [ISBN:0073040584] is_a: UBERON:0000075 ! subdivision of skeletal system relationship: BFO:0000050 UBERON:0003113 ! part of dermatocranium relationship: BFO:0000050 UBERON:0007375 ! part of roof of mouth property_value: skos:prefLabel "palatal part of dermatocranium" xsd:string [Term] id: UBERON:0012075 name: replacement bone def: "Bone that forms as a replacement of another structural tissue." [ZFA:0001628] synonym: "replacement bones" EXACT OMO:0003004 [ZFA:0001628] xref: AAO:0010768 xref: TAO:0001637 xref: ZFA:0001628 is_a: UBERON:0001474 {source="ZFA"} ! bone element is_a: UBERON:0010522 {source="ZFA"} ! replacement element property_value: skos:prefLabel "replacement bone" xsd:string [Term] id: UBERON:0012080 name: patella cartilage element def: "A cartilaginous condensation that has the potential to develop into a patella." [OBOL:automatic] xref: EMAPA:19140 is_a: UBERON:0003860 ! hindlimb mesenchyme is_a: UBERON:0005863 ! cartilaginous condensation intersection_of: UBERON:0005863 ! cartilaginous condensation intersection_of: RO:0002387 UBERON:0002446 ! has potential to develop into patella relationship: BFO:0000050 UBERON:0001441 ! part of hindlimb skeleton relationship: RO:0002202 UBERON:0012081 ! develops from patella pre-cartilage condensation relationship: RO:0002220 UBERON:0001485 ! adjacent to knee joint relationship: RO:0002387 UBERON:0002446 ! has potential to develop into patella property_value: IAO:0000116 "Note some sources have this as intramembranous" xsd:string [Term] id: UBERON:0012081 name: patella pre-cartilage condensation def: "A pre-cartilage condensation that has the potential to develop into a patella." [OBOL:automatic] xref: EMAPA:18510 is_a: UBERON:0003321 ! mesenchyme of knee is_a: UBERON:0005866 ! pre-cartilage condensation intersection_of: UBERON:0005866 ! pre-cartilage condensation intersection_of: RO:0002387 UBERON:0002446 ! has potential to develop into patella relationship: BFO:0000050 UBERON:0001441 ! part of hindlimb skeleton relationship: BFO:0000050 UBERON:0006256 {source="EMAPA"} ! part of knee joint primordium relationship: RO:0002387 UBERON:0002446 ! has potential to develop into patella [Term] id: UBERON:0012082 name: bronchial lumen def: "An anatomical cavity that is part of a bronchus." [OBOL:automatic] synonym: "bronchial lumen" EXACT [FMA:62646] synonym: "lumen of bronchus" EXACT [FMA:62646] xref: FMA:62646 xref: SCTID:199401001 is_a: UBERON:0000464 ! anatomical space intersection_of: UBERON:0000464 {source="FMA"} ! anatomical space intersection_of: RO:0002572 UBERON:0002185 {source="FMA"} ! luminal space of bronchus relationship: RO:0002572 UBERON:0002185 ! luminal space of bronchus property_value: skos:prefLabel "bronchial lumen" xsd:string [Term] id: UBERON:0012084 name: lumen of secondary bronchus def: "An anatomical cavity that is part of a lobar bronchus." [OBOL:automatic] synonym: "lobar bronchial lumen" EXACT [FMA:62520] synonym: "lumen of lobar bronchus" EXACT [FMA:62520] synonym: "secondary bronchial lumen" EXACT [] xref: FMA:62520 is_a: UBERON:0012082 ! bronchial lumen intersection_of: UBERON:0000464 ! anatomical space intersection_of: RO:0002572 UBERON:0002183 ! luminal space of lobar bronchus relationship: RO:0002572 UBERON:0002183 ! luminal space of lobar bronchus [Term] id: UBERON:0012085 name: lumen of tertiary bronchus def: "An anatomical cavity that is part of a segmental bronchus." [OBOL:automatic] synonym: "lumen of segmental bronchus" EXACT [FMA:62593] synonym: "segmental bronchial lumen" EXACT [FMA:62593] xref: FMA:62593 is_a: UBERON:0012082 ! bronchial lumen intersection_of: UBERON:0000464 ! anatomical space intersection_of: RO:0002572 UBERON:0002184 ! luminal space of segmental bronchus relationship: RO:0002572 UBERON:0002184 ! luminal space of segmental bronchus [Term] id: UBERON:0012102 name: buccal salivary gland def: "A salivary gland that is part of a cheek." [OBOL:automatic] xref: FMA:59793 xref: NCIT:C32237 is_a: UBERON:0001044 ! saliva-secreting gland intersection_of: UBERON:0001044 ! saliva-secreting gland intersection_of: BFO:0000050 UBERON:0001567 ! part of cheek relationship: BFO:0000050 UBERON:0001567 ! part of cheek [Term] id: UBERON:0012139 name: segment of autopod is_a: UBERON:0002529 ! limb segment relationship: BFO:0000050 UBERON:0002470 ! part of autopod region [Term] id: UBERON:0012140 name: digitopodium region def: "A segment of the autopod consisting of both acropodial region and metapodial region, but excluding the mesopodial/basopodial region." [https://github.com/obophenotype/uberon/issues/131, PHENOSCAPE:ni] synonym: "acropodium (Wagner)" RELATED [] is_a: UBERON:0012139 ! segment of autopod intersection_of: UBERON:0012139 ! segment of autopod intersection_of: RO:0002551 UBERON:0012150 ! has skeleton skeleton of digitopodium relationship: RO:0002220 UBERON:0006716 ! adjacent to mesopodium region relationship: RO:0002551 UBERON:0012150 ! has skeleton skeleton of digitopodium property_value: seeAlso "https://github.com/obophenotype/uberon/wiki/Subdivisions-of-the-autopod" xsd:anyURI [Term] id: UBERON:0012141 name: manual digitopodium region def: "A digitopodium region that is part of a manus[Obol]. This includes the fingers and metacarpal region, but excludes the carpal region." [http://orcid.org/0000-0002-6601-2165] is_a: UBERON:0005451 ! segment of manus is_a: UBERON:0012140 ! digitopodium region intersection_of: UBERON:0012140 ! digitopodium region intersection_of: BFO:0000050 UBERON:0002398 ! part of manus relationship: RO:0002551 UBERON:0012151 ! has skeleton skeleton of manual digitopodium property_value: seeAlso "https://github.com/obophenotype/uberon/wiki/Subdivisions-of-the-autopod" xsd:anyURI [Term] id: UBERON:0012142 name: pedal digitopodium region def: "A digitopodium region that is part of a pes[Obol]. This includes the toes and metatarsal region, but excludes the tarsals region." [http://orcid.org/0000-0002-6601-2165] is_a: UBERON:0005445 ! segment of pes is_a: UBERON:0012140 ! digitopodium region intersection_of: UBERON:0012140 ! digitopodium region intersection_of: BFO:0000050 UBERON:0002387 ! part of pes relationship: RO:0002551 UBERON:0012152 ! has skeleton skeleton of pedal digitopodium property_value: seeAlso "https://github.com/obophenotype/uberon/wiki/Subdivisions-of-the-autopod" xsd:anyURI [Term] id: UBERON:0012150 name: skeleton of digitopodium def: "A subdivision of the autopod skeleton consisting of both acropodial skeleon and metapodial skeleton, but excluding the mesopodial/basopodial skeleton." [PHENOSCAPE:ni] synonym: "digitopodium" RELATED [PHENOSCAPE:ni] synonym: "skeleton of digits" RELATED COMPARATIVE_PREFERRED [] is_a: UBERON:0010712 ! limb skeleton subdivision intersection_of: UBERON:0010912 ! subdivision of skeleton intersection_of: RO:0002576 UBERON:0012140 ! skeleton of digitopodium region relationship: BFO:0000050 UBERON:0006717 ! part of autopodial skeleton relationship: RO:0002576 UBERON:0012140 ! skeleton of digitopodium region property_value: seeAlso "https://github.com/obophenotype/uberon/wiki/Subdivisions-of-the-autopod" xsd:anyURI [Term] id: UBERON:0012151 name: skeleton of manual digitopodium def: "A subdivision of the manus skeleton consisting of both manual acropodial skeleton and metacarpal skeleton, but excluding the carpal skeleton." [https://orcid.org/0000-0002-6601-2165, PHENOSCAPE:ni] synonym: "manual digitopodium" RELATED [] is_a: UBERON:0012150 ! skeleton of digitopodium intersection_of: UBERON:0012150 ! skeleton of digitopodium intersection_of: BFO:0000050 UBERON:0002398 ! part of manus relationship: BFO:0000050 UBERON:0001442 ! part of skeleton of manus relationship: BFO:0000050 UBERON:0012141 {source="FMA"} ! part of manual digitopodium region property_value: seeAlso "https://github.com/obophenotype/uberon/wiki/Subdivisions-of-the-autopod" xsd:anyURI [Term] id: UBERON:0012152 name: skeleton of pedal digitopodium def: "A subdivision of the pes skeleton consisting of both pedal acropodial skeleton and metatarsal skeleton, but excluding the tarsal skeleton." [https://orcid.org/0000-0002-6601-2165, PHENOSCAPE:ni] synonym: "pedal digitopodium" RELATED [] is_a: UBERON:0012150 ! skeleton of digitopodium intersection_of: UBERON:0012150 ! skeleton of digitopodium intersection_of: BFO:0000050 UBERON:0002387 ! part of pes relationship: BFO:0000050 UBERON:0001445 ! part of skeleton of pes relationship: BFO:0000050 UBERON:0012142 ! part of pedal digitopodium region property_value: seeAlso "https://github.com/obophenotype/uberon/wiki/Subdivisions-of-the-autopod" xsd:anyURI [Term] id: UBERON:0012168 name: umbilical cord blood def: "Blood that remains in the placenta and in the attached umbilical cord after childbirth[WP]." [Wikipedia:Cord_blood] comment: Cord blood is collected because it contains stem cells, which can be used to treat hematopoietic and genetic disorders.[WP] subset: efo_slim synonym: "cord blood" RELATED [BTO:0004053] synonym: "fetal blood" RELATED [MESH:A12.207.152.200] synonym: "umbilical cord blood" RELATED [MESH:A12.207.152.200] xref: BTO:0004053 xref: CALOHA:TS-1079 xref: EFO:0001942 xref: MESH:D005312 xref: Wikipedia:Cord_blood is_a: UBERON:0013755 ! arterial blood intersection_of: UBERON:0000178 ! blood intersection_of: RO:0001025 UBERON:0001310 ! located in umbilical artery relationship: BFO:0000050 UBERON:0000323 ! part of late embryo relationship: RO:0001025 UBERON:0001310 ! located in umbilical artery [Term] id: UBERON:0012172 name: stomach primordium def: "A primordium that has the potential to develop into a stomach." [OBOL:automatic] subset: efo_slim synonym: "stomach endoderm" RELATED [EFO:0002580] xref: EFO:0002580 xref: NCIT:C34305 xref: UMLS:C1514976 {source="ncithesaurus:Stomach_Primordium"} is_a: UBERON:0001048 ! primordium intersection_of: UBERON:0001048 ! primordium intersection_of: RO:0002387 UBERON:0000945 ! has potential to develop into stomach relationship: BFO:0000050 UBERON:0003258 ! part of endoderm of foregut relationship: RO:0002387 UBERON:0000945 ! has potential to develop into stomach property_value: skos:prefLabel "stomach primordium" xsd:string [Term] id: UBERON:0012175 name: acoustico-facial VII-VIII ganglion complex synonym: "acousticofacial ganglion" EXACT [] synonym: "facio-acoustic ganglion" EXACT [] synonym: "facio-acoustic ganglion complex" RELATED [EMAPA:16794] synonym: "facio-acoustic ganglion complex VII-VIII" EXACT [EMAPA:16794] synonym: "facio-acoustic VII-VIII ganglion complex" RELATED [VHOG:0000715] xref: EHDAA2:0000494 xref: EMAPA:16794 xref: SCTID:361514006 is_a: UBERON:0001714 {source="cjm"} ! cranial ganglion is_a: UBERON:0010313 ! neural crest-derived structure relationship: RO:0002202 UBERON:0003051 {source="EHDAA2"} ! develops from ear vesicle relationship: RO:0002202 UBERON:0006232 {source="cjm"} ! develops from facio-acoustic VII-VIII preganglion complex property_value: skos:prefLabel "acoustico-facial VII-VIII ganglion complex" xsd:string [Term] id: UBERON:0012177 name: skin apocrine gland def: "An apocrine gland that is part of a skin of body." [OBOL:automatic] comment: Note that 'skin apocrine gland' does not cover 'apocrine sweat gland': in the former, "apocrine" refers to the type of secretion mechanism, while in the latter it refers to a structural feature. xref: MA:0000147 is_a: UBERON:0002419 {source="MA"} ! skin gland is_a: UBERON:0008974 ! apocrine gland is_a: UBERON:0019319 ! exocrine gland of integumental system intersection_of: UBERON:0008974 ! apocrine gland intersection_of: BFO:0000050 UBERON:0002097 ! part of skin of body [Term] id: UBERON:0012180 name: head or neck skin def: "A zone of skin that is part of a craniocervical region." [OBOL:automatic] xref: EMAPA:37276 {source="MA:th"} xref: MA:0000574 xref: NCIT:C12294 xref: UMLS:C1522650 {source="ncithesaurus:Skin_of_the_Scalp_and_Neck"} is_a: UBERON:0000014 ! zone of skin intersection_of: UBERON:0000014 ! zone of skin intersection_of: BFO:0000050 UBERON:0007811 ! part of craniocervical region relationship: BFO:0000050 UBERON:0007811 ! part of craniocervical region property_value: skos:prefLabel "head or neck skin" xsd:string [Term] id: UBERON:0012186 name: ovary growing follicle def: "An ovarian follicle undergoing maturation." [ncithesaurus:Growing_Follicle] xref: EMAPA:35628 xref: MA:0001708 xref: NCIT:C32702 xref: UMLS:C1512279 {source="ncithesaurus:Growing_Follicle"} is_a: UBERON:0001305 {source="MA"} ! ovarian follicle [Term] id: UBERON:0012193 name: phrenic vein def: "The veins that run parallel to the phrenic arteries which include the two superior and two inferior phrenic veins." [ncithesaurus:Phrenic_Vein] xref: EMAPA:37180 {source="MA:th"} xref: MA:0002194 xref: NCIT:C53062 xref: UMLS:C1709532 {source="ncithesaurus:Phrenic_Vein"} is_a: UBERON:0001638 ! vein intersection_of: UBERON:0001638 ! vein intersection_of: RO:0020102 UBERON:0001103 ! vessel drains blood from diaphragm relationship: RO:0020102 UBERON:0001103 ! vessel drains blood from diaphragm property_value: skos:prefLabel "phrenic vein" xsd:string [Term] id: UBERON:0012239 name: urinary bladder vasculature def: "Network of tubes that carries blood through the distensible musculomembranous organ that serves to collect and store urine excreted by the kidneys[MP]." [MP:MP] subset: human_reference_atlas subset: pheno_slim synonym: "bladder vasculature" EXACT [] synonym: "blood vessel of bladder" RELATED [EMAPA:28679] synonym: "blood vessels of bladder" EXACT [EMAPA:28679] synonym: "set of urinary bladder blood vessels" EXACT [] xref: EMAPA:28679 is_a: UBERON:0002201 ! vasculature of trunk is_a: UBERON:0006876 ! vasculature of organ intersection_of: UBERON:0002049 {source="EMAPA"} ! vasculature intersection_of: BFO:0000050 UBERON:0001255 {source="EMAPA"} ! part of urinary bladder relationship: BFO:0000050 UBERON:0001255 ! part of urinary bladder relationship: RO:0002433 UBERON:0001255 ! contributes to morphology of urinary bladder property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0012240 name: urethral meatus def: "External opening or orifice of the urethra through which urine and seminal fluid (in males only) leave the body; in males the meatus presents as a vertical slit normally positioned at the tip of glans penis; in females the meatus is located between the clitoris and the vagina in the vulvular vestibule of the female genitalia[MP]." [MP:MP, Wikipedia:Urinary_meatus] subset: pheno_slim synonym: "external meatus of urethra" EXACT [FMA:19650] synonym: "external urethral orifice" EXACT [FMA:19650] synonym: "external urethral ostium" EXACT [FMA:19650] synonym: "external urinary meatus" EXACT [FMA:19650] synonym: "meatus urinarius" EXACT OMO:0003011 [] synonym: "orificium urethrae externum" EXACT OMO:0003011 [] synonym: "orificium urethræ externum" EXACT OMO:0003011 [] synonym: "urethral meatus" EXACT [FMA:19650] synonym: "urinary meatus" RELATED [] xref: EMAPA:37977 {source="MA:th"} xref: FMA:19650 xref: SCTID:181424008 xref: Wikipedia:Urinary_meatus is_a: UBERON:0010418 ! urethral opening intersection_of: UBERON:0000161 ! orifice intersection_of: BFO:0000050 UBERON:0000057 ! part of urethra intersection_of: RO:0002176 UBERON:0010390 ! connects lumen of urethra intersection_of: RO:0002176 UBERON:0013514 ! connects space surrounding organism relationship: BFO:0000050 UBERON:0000057 ! part of urethra relationship: RO:0002176 UBERON:0010390 ! connects lumen of urethra relationship: RO:0002176 UBERON:0013514 ! connects space surrounding organism [Term] id: UBERON:0012241 name: male urethral meatus def: "A urethral meatus that is part of a male urethra[Automatically generated definition]." [OBOL:automatic, Wikipedia:External_urethral_orifice_(male)] synonym: "distal urethral opening of male" RELATED [EMAPA:36434] synonym: "external orifice of male urethra" EXACT [FMA:85265] synonym: "external urethral orifice (male)" EXACT [FMA:85265] synonym: "male urethra ostium" EXACT [MA:0002642] synonym: "ostium urethrae externum (urethra masculina)" EXACT OMO:0003011 [FMA:TA] synonym: "urethral meatus of penile urethra" EXACT [EMAPA:36434] synonym: "urethral opening of penile urethra" RELATED [EMAPA:36434] xref: EMAPA:36434 xref: FMA:85265 xref: MA:0002642 xref: SCTID:279478000 xref: Wikipedia:External_urethral_orifice_(male) is_a: UBERON:0005156 ! reproductive structure is_a: UBERON:0012240 ! urethral meatus intersection_of: UBERON:0012240 ! urethral meatus intersection_of: BFO:0000050 UBERON:0003101 ! part of male organism relationship: BFO:0000050 UBERON:0001299 ! part of glans penis relationship: BFO:0000050 UBERON:0001333 ! part of male urethra [Term] id: UBERON:0012242 name: internal urethral orifice def: "The usually crescent-shaped opening of the urinary bladder into the urethra, placed at the anteroinferior angle (apex) of the urinary bladder trigone." [MGI:anna, MP:0011782] subset: pheno_slim synonym: "internal meatus of urethra" EXACT [FMA:85263] synonym: "internal urethral orifice of urinary bladder" EXACT [FMA:85263] synonym: "internal urethral ostium" EXACT [FMA:85263] synonym: "internal urethral ostium" RELATED [MP:0011782] synonym: "internal urinary meatus" RELATED [MP:0011782] synonym: "orificium urethrae internum" EXACT OMO:0003011 [MP:0011782] synonym: "ostium orificium internum" EXACT OMO:0003011 [] synonym: "ostium urethrae internum" EXACT OMO:0003011 [Wikipedia:Internal_urethral_orifice] synonym: "vesicourethral orifice" EXACT [FMA:85263] xref: FMA:85263 xref: SCTID:362228001 xref: Wikipedia:Internal_urethral_orifice is_a: UBERON:0010418 ! urethral opening intersection_of: UBERON:0000161 ! orifice intersection_of: BFO:0000050 UBERON:0000057 ! part of urethra intersection_of: RO:0002176 UBERON:0009958 ! connects bladder lumen intersection_of: RO:0002176 UBERON:0010390 ! connects lumen of urethra relationship: BFO:0000050 UBERON:0000057 ! part of urethra relationship: RO:0002176 UBERON:0009958 ! connects bladder lumen relationship: RO:0002176 UBERON:0010390 ! connects lumen of urethra [Term] id: UBERON:0012246 name: thyroid follicular lumen def: "A follicular lumen is the closed cavity within a follicle of the thyroid gland. It is surrounded by follicular cells and filled with colloid, a concentrated solution of thyroglobulin." [Wikipedia:Follicular_lumen] synonym: "follicular lumen" BROAD [Wikipedia:Follicular_lumen] synonym: "lumen of thyroid follicle" EXACT [FMA:68829] synonym: "thyroid follicle lumen" EXACT [FMA:68829] synonym: "thyroid follicular space" EXACT [FMA:68829] xref: FMA:68829 xref: Wikipedia:Follicular_lumen is_a: UBERON:0000464 ! anatomical space intersection_of: UBERON:0000464 ! anatomical space intersection_of: RO:0002572 UBERON:0005305 ! luminal space of thyroid follicle relationship: RO:0002219 UBERON:0012363 ! surrounded by thyroid follicle epithelium relationship: RO:0002572 UBERON:0005305 ! luminal space of thyroid follicle [Term] id: UBERON:0012247 name: cervical gland def: "Mucus-secreting glands in the mucosa of the uterine cervix." [http://www.thefreedictionary.com/cervical+glands] subset: human_reference_atlas synonym: "glandulae cervicales" EXACT [FMA:TA] xref: NCIT:C32296 xref: SCTID:280836000 xref: UMLS:C2724437 {source="ncithesaurus:Cervical_Gland"} is_a: UBERON:0002451 ! endometrial gland intersection_of: UBERON:0002365 ! exocrine gland intersection_of: BFO:0000050 UBERON:0000002 ! part of uterine cervix relationship: BFO:0000050 UBERON:0012248 ! part of cervical mucosa property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0012248 name: cervical mucosa def: "Lining of the head of the uterus (cervix); contains large branched glands; does not undergo sloughing." [BTO:0000411] xref: BTO:0000411 is_a: UBERON:0001295 ! endometrium intersection_of: UBERON:0000344 ! mucosa intersection_of: BFO:0000050 UBERON:0000002 ! part of uterine cervix relationship: BFO:0000050 UBERON:0000002 ! part of uterine cervix [Term] id: UBERON:0012249 name: ectocervix def: "The part of the cervix uteri that protrudes into the vagina and is lined with stratified squamous epithelium." [BTO:0001850, Wikipedia:Vaginal_portion_of_cervix] subset: human_reference_atlas synonym: "ectocervix" EXACT [BTO:0001850, FMA:86484] synonym: "exocervix" RELATED [BTO:0001850] synonym: "portio vaginalis" EXACT [Wikipedia:Vaginal_portion_of_cervix] synonym: "portio vaginalis cervicis" EXACT OMO:0003011 [BTO:0001850] synonym: "uterine ectocervix" EXACT [CALOHA:TS-1098] synonym: "vaginal part of cervix" EXACT [FMA:77056] xref: BTO:0001850 xref: CALOHA:TS-1098 xref: FMA:77056 xref: FMA:86484 xref: NCIT:C12310 xref: SCTID:264459002 xref: UMLS:C0227829 {source="ncithesaurus:Ectocervix"} xref: Wikipedia:Vaginal_portion_of_cervix is_a: UBERON:0000064 ! organ part is_a: UBERON:0005156 ! reproductive structure intersection_of: UBERON:0000064 ! organ part intersection_of: BSPO:0001108 UBERON:0000002 ! uterine cervix relationship: BFO:0000051 UBERON:0010304 ! has part non-keratinized stratified squamous epithelium relationship: BSPO:0000100 UBERON:0000996 ! vagina relationship: BSPO:0001108 UBERON:0000002 ! uterine cervix property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0012250 name: cervix glandular epithelium def: "A glandular epithelium that is part of a uterine cervix." [OBOL:automatic] subset: human_reference_atlas synonym: "cervix columnar epithelium" RELATED [] xref: NCIT:C54414 xref: UMLS:C1707350 {source="ncithesaurus:Cervix_Columnar_Epithelium"} is_a: UBERON:0004801 ! cervix epithelium is_a: UBERON:0006799 ! glandular epithelium intersection_of: UBERON:0006799 ! glandular epithelium intersection_of: BFO:0000050 UBERON:0000002 ! part of uterine cervix property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0012251 name: ectocervical epithelium def: "An epithelium that is part of a ectocervix." [OBOL:automatic] synonym: "exocervical epithelium" EXACT [] xref: SCTID:361376000 is_a: UBERON:0004801 ! cervix epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: BFO:0000050 UBERON:0012249 ! part of ectocervix relationship: BFO:0000050 UBERON:0012249 ! part of ectocervix [Term] id: UBERON:0012252 name: endocervical epithelium def: "The glandular epithelium that lines the endocervix." [ncithesaurus:Endocervical_Glandular_Epithelium] subset: human_reference_atlas synonym: "endocervical glandular epithelium" EXACT [] xref: NCIT:C96180 xref: SCTID:362256006 is_a: UBERON:0012250 ! cervix glandular epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: BFO:0000050 UBERON:0000458 ! part of endocervix relationship: BFO:0000050 UBERON:0000458 ! part of endocervix property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0012253 name: cervical squamo-columnar junction def: "Region of cervical epithelium where columnar epithelium of endocervic and the stratified non-keratinising squamous epithelium of the ectocervic meet." [http://www.asccp.org/practicemanagement/cervix/histologyofthenormalcervix/tabid/5842/default.aspx] comment: Site of 90% of lower genital tract neoplasia. This junction is presumed, but not proven, to be the embryologic junction of the Müllerian and urogenital sinus epithelia. synonym: "squamo-columnar junction of uterine cervix" EXACT [] synonym: "squamocolumnar junction" BROAD [] synonym: "squamocolumnar junction of uterine cervix" EXACT [] xref: NCIT:C97148 xref: SCTID:280451001 is_a: UBERON:0004801 ! cervix epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: BFO:0000050 UBERON:0000002 ! part of uterine cervix intersection_of: RO:0002150 UBERON:0006922 ! continuous with cervix squamous epithelium intersection_of: RO:0002150 UBERON:0012250 ! continuous with cervix glandular epithelium relationship: RO:0002150 UBERON:0006922 ! continuous with cervix squamous epithelium relationship: RO:0002150 UBERON:0012250 ! continuous with cervix glandular epithelium [Term] id: UBERON:0012254 name: abdominal aorta artery def: "An artery that originates from the abdominal aorta." [https://orcid.org/0000-0002-6601-2165, Wikipedia:Abdominal_aorta#Branches] subset: pheno_slim synonym: "abdominal artery" EXACT [] synonym: "artery of abdomen" EXACT [] xref: SCTID:281470000 is_a: UBERON:0004573 ! systemic artery intersection_of: UBERON:0001637 ! artery intersection_of: RO:0002380 UBERON:0001516 ! branching part of abdominal aorta relationship: RO:0002380 UBERON:0001516 ! branching part of abdominal aorta property_value: skos:prefLabel "abdominal aorta artery" xsd:string [Term] id: UBERON:0012274 name: columnar epithelium def: "An epithelium that consists of columnar epithelial cells. Columnar epithelia are epithelial cells whose heights are at least four times their width. Columnar epithelia are divided into simple (or unilayered), and the rarer stratified (or multi-layered).[WP, modified]." [Wikipedia:Columnar_epithelium] xref: Wikipedia:Columnar_epithelium is_a: UBERON:0000483 ! epithelium relationship: BFO:0000051 CL:0000075 ! has part columnar/cuboidal epithelial cell property_value: skos:prefLabel "columnar epithelium" xsd:string [Term] id: UBERON:0012275 name: meso-epithelium def: "Epithelium that derives from the mesoderm. [Automatically generated definition]." [OBOL:automatic] synonym: "mesoderm-derived epithelium" EXACT [] synonym: "mesoepithelium" EXACT [] xref: FMA:86452 is_a: UBERON:0000483 ! epithelium is_a: UBERON:0004120 ! mesoderm-derived structure intersection_of: UBERON:0000483 ! epithelium intersection_of: RO:0002202 UBERON:0000926 ! develops from mesoderm property_value: skos:prefLabel "meso-epithelium" xsd:string [Term] id: UBERON:0012276 name: endometrium glandular epithelium subset: human_reference_atlas synonym: "glandular part of endometrium" EXACT [FMA:86488] synonym: "uterine glands" EXACT [] synonym: "uterine glands set" EXACT [] xref: EMAPA:35308 xref: FMA:86488 xref: MA:0002732 is_a: UBERON:0004811 ! endometrium epithelium is_a: UBERON:0006929 ! glandular columnar epithelium is_a: UBERON:0007589 ! ciliated columnar oviduct epithelium intersection_of: UBERON:0006799 ! glandular epithelium intersection_of: BFO:0000050 UBERON:0004811 ! part of endometrium epithelium relationship: BFO:0000050 UBERON:0004811 ! part of endometrium epithelium property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0012278 name: gland of nasal mucosa def: "The nasal glands are the seromucous glands in the respiratory region of the nasal mucous membrane. The three major types of nasal glands are anterior serous glands, seromucous glands, and Bowman glands." [Wikipedia:Nasal_glands] subset: pheno_slim synonym: "glandula nasalis" EXACT OMO:0003011 [] synonym: "glandulae nasales" EXACT OMO:0003011 [] synonym: "nasal gland" BROAD [] xref: EMAPA:37871 {source="MA:th"} xref: FMA:321518 xref: NCIT:C22725 xref: SCTID:368881007 xref: UMLS:C1522269 {source="ncithesaurus:Nose_Nasal_Cavity_Nasal_Gland_MMHCC"} xref: Wikipedia:Nasal_glands is_a: UBERON:0002365 ! exocrine gland is_a: UBERON:0036225 ! respiratory system gland intersection_of: UBERON:0002530 ! gland intersection_of: BFO:0000050 UBERON:0001826 ! part of nasal cavity mucosa relationship: BFO:0000050 UBERON:0001826 ! part of nasal cavity mucosa relationship: BFO:0000051 CL:0000159 ! has part seromucus secreting cell [Term] id: UBERON:0012279 name: chromaffin paraganglion def: "Small bodies containing chromaffin cells occurring outside of the adrenal medulla, most commonly near the sympathetic ganglia and in organs such as the kidney, liver, heart and gonads." [MESH:A06.224.736, Wikipedia:Paraganglion] synonym: "chromaffin body" RELATED [MESH:A06.224.736] synonym: "chromaffin paraganglia" RELATED OMO:0003004 [MESH:A06.224.736] synonym: "chromaffin paraganglion" RELATED [MESH:A06.224.736] synonym: "paraganglion" BROAD [ncithesaurus:Paraganglion] xref: CALOHA:TS-2358 xref: MESH:D010233 xref: NCIT:C94826 xref: UMLS:C0030419 {source="ncithesaurus:Paraganglion"} is_a: UBERON:0034978 ! paraganglion (generic) relationship: BFO:0000050 UBERON:0010074 ! part of chromaffin system relationship: RO:0002473 CL:0000166 ! composed primarily of chromaffin cell [Term] id: UBERON:0012287 name: Rathkes pouch epithelium def: "An epithelial sac that is part of a Rathke's pouch." [OBOL:automatic] xref: EHDAA2:0001473 xref: EMAPA:25036 is_a: UBERON:0004906 ! ectodermal part of digestive tract is_a: UBERON:0007499 ! epithelial sac is_a: UBERON:0009854 ! digestive tract diverticulum is_a: UBERON:0011642 ! oral epithelium from ectoderm intersection_of: UBERON:0007499 ! epithelial sac intersection_of: BFO:0000050 UBERON:0005356 ! part of Rathke's pouch intersection_of: RO:0002220 UBERON:0009974 ! adjacent to lumen of Rathke's pouch relationship: BFO:0000050 UBERON:0005356 ! part of Rathke's pouch relationship: BFO:0000050 UBERON:0011642 {source="EHDAA2"} ! part of oral epithelium from ectoderm relationship: RO:0002220 UBERON:0009974 ! adjacent to lumen of Rathke's pouch property_value: IAO:0000116 "See https://github.com/obophenotype/uberon/issues/1305" xsd:string property_value: skos:prefLabel "Rathkes pouch epithelium" xsd:string [Term] id: UBERON:0012292 name: embryonic cloacal fold def: "One of the pair of mesenchymal swellings (folds) located on either side of the cloacal membrane during the indifferent stage of embryonic development; cranial to the cloacal membrane the folds unite to form the genital tubercle; caudally the folds are subdivided into urogenital folds anteriorly and anal folds posteriorly." [MP:0011836, MP:anna] comment: We presume this is distinct from AAO:0001003, an external integumentary structure - check with amphibian anatomy ontology developers. AO notes: the text def states mesenchymal swelling, EHDAA2 splits into mesenchymal and epithelial parts synonym: "cloacal fold" BROAD [EHDAA2:0004009] xref: EHDAA2:0004009 is_a: UBERON:0000481 ! multi-tissue structure relationship: BFO:0000050 UBERON:0000922 ! part of embryo relationship: BFO:0000050 UBERON:0012469 {source="EHDAA2"} ! part of external anal region relationship: RO:0002220 UBERON:0006217 ! adjacent to cloacal membrane [Term] id: UBERON:0012299 name: mucosa of urethra def: "A mucosa that is part of a urethra." [OBOL:automatic] synonym: "mucous membrane of urethra" EXACT [FMA:76904] synonym: "tunica mucosa urethrae" EXACT [FMA:TA] synonym: "urethral mucosa" EXACT [FMA:76904] xref: EMAPA:37912 {source="MA:th"} xref: FMA:76904 xref: SCTID:362229009 is_a: UBERON:0000344 ! mucosa intersection_of: UBERON:0000344 ! mucosa intersection_of: BFO:0000050 UBERON:0000057 ! part of urethra relationship: BFO:0000050 UBERON:0000057 ! part of urethra [Term] id: UBERON:0012313 name: 1st arch maxillary ectoderm synonym: "ectoderm of maxillary component" EXACT [EMAPA:16389] xref: EHDAA2:0000039 xref: EMAPA:16389 is_a: BFO:0000002 is_a: UBERON:0000490 {source="EHDAA2"} ! unilaminar epithelium is_a: UBERON:0005291 ! embryonic tissue is_a: UBERON:0015833 ! foregut epithelium relationship: BFO:0000050 UBERON:0000076 {source="EHDAA2"} ! part of external ectoderm relationship: BFO:0000050 UBERON:0007238 {source="EHDAA2"} ! part of 1st arch maxillary component relationship: RO:0002202 UBERON:0000076 {source="EHDAA2"} ! develops from external ectoderm [Term] id: UBERON:0012314 name: embryonic facial prominence def: "One of five swellings formed during the development of the face." [http://www.indiana.edu/~anat550/hnanim/face/face.html] synonym: "embryonic facial process" RELATED [] synonym: "facial primordium" RELATED [] synonym: "primordium of face" RELATED [] xref: FMA:293103 xref: SCTID:89066004 is_a: UBERON:0002050 ! embryonic structure relationship: BFO:0000050 UBERON:0000033 ! part of head relationship: RO:0002162 NCBITaxon:7742 ! in taxon Vertebrata property_value: skos:prefLabel "embryonic facial prominence" xsd:string [Term] id: UBERON:0012317 name: vagina orifice def: "The median slit located inferior and posterior to the external urethral orifice in the female; the exit for menstrual flow and birth and the entrance for the penis during sexual intercourse; the size and appearance of the vaginal orifice varies inversely with that of the hymen (G. membrane), a thin fold of mucous membrane that surrounds the vaginal orifice." [MGI:anna, MGI:csmith, MP:0001142] subset: pheno_slim synonym: "introitus" BROAD [FMA:19984] synonym: "introitus" RELATED INCONSISTENT [FMA:19984] synonym: "introitus of vagina" RELATED [MP:0001142] synonym: "opening of vagina" EXACT [] synonym: "orifice of vagina" EXACT [FMA:19984] synonym: "ostium vaginae" EXACT [FMA:TA] synonym: "vagina opening" EXACT [MP:0001142] synonym: "vaginal introitus" RELATED [] synonym: "vaginal orifice" EXACT [FMA:19984] xref: EMAPA:37983 {source="MA:th"} xref: FMA:19984 xref: Wikipedia:Vaginal_orifice is_a: UBERON:0000161 ! orifice is_a: UBERON:0005156 ! reproductive structure intersection_of: UBERON:0000161 ! orifice intersection_of: BFO:0000050 UBERON:0000996 ! part of vagina relationship: BFO:0000050 UBERON:0000996 ! part of vagina relationship: RO:0002433 UBERON:0000996 ! contributes to morphology of vagina [Term] id: UBERON:0012320 name: cervical artery def: "An artery of the neck." [https://orcid.org/0000-0002-6601-2165] xref: EMAPA:37075 {source="MA:th"} xref: NCIT:C52850 xref: UMLS:C1707349 {source="ncithesaurus:Cervical_Artery"} is_a: UBERON:0001637 ! artery is_a: UBERON:0003502 ! neck blood vessel intersection_of: UBERON:0001637 ! artery intersection_of: BFO:0000050 UBERON:0000974 ! part of neck property_value: skos:prefLabel "cervical artery" xsd:string [Term] id: UBERON:0012321 name: deep cervical artery def: "The deep cervical artery (Profunda cervicalis) is an artery of the neck." [Wikipedia:Deep_cervical_artery] subset: human_reference_atlas synonym: "profunda cervicalis" RELATED [Wikipedia:Deep_cervical_artery] xref: FMA:10659 xref: SCTID:244223002 xref: Wikipedia:Deep_cervical_artery is_a: UBERON:0012320 ! cervical artery intersection_of: UBERON:0012320 ! cervical artery intersection_of: BFO:0000050 UBERON:0035551 ! part of deep vasculature relationship: BFO:0000050 UBERON:0035551 ! part of deep vasculature relationship: RO:0002252 UBERON:0004688 {source="FMA"} ! connecting branch of costo-cervical trunk property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "deep cervical artery" xsd:string [Term] id: UBERON:0012324 name: transverse cervical artery def: "The transverse cervical artery (transverse artery of neck, transversa colli artery) is a branch of the thyrocervical trunk, running at a higher level than the suprascapular artery." [Wikipedia:Transverse_cervical_artery] subset: human_reference_atlas synonym: "cervical artery" RELATED [MA:0001936, Wikipedia:Transverse_cervical_artery] synonym: "cervical transverse artery" RELATED [Wikipedia:Transverse_cervical_artery] synonym: "descending branch of the transverse cervical" RELATED [Wikipedia:Transverse_cervical_artery] synonym: "transversalis artery colli" RELATED [Wikipedia:Transverse_cervical_artery] synonym: "transversalis colli artery" RELATED [Wikipedia:Transverse_cervical_artery] synonym: "transverse cervical" RELATED [Wikipedia:Transverse_cervical_artery] synonym: "transverse cervical vessels" RELATED [Wikipedia:Transverse_cervical_artery] xref: FMA:10664 xref: MA:0001936 xref: SCTID:244224008 xref: Wikipedia:Transverse_cervical_artery is_a: UBERON:0012320 ! cervical artery property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "transverse cervical artery" xsd:string [Term] id: UBERON:0012329 name: keratinized stratified squamous epithelium def: "Keratinized stratified squamous epithelium is a stratified squamous epithelium, the cells of which synthesize and accumulate keratin." [FMA:45568, Wikipedia:Stratified_squamous_epithelium#Keratinized] synonym: "epithelium stratificatum squamosum cornificatum" EXACT OMO:0003011 [FMA:45568] xref: FMA:45568 xref: Wikipedia:Stratified_squamous_epithelium#Keratinized is_a: UBERON:0006915 ! stratified squamous epithelium intersection_of: UBERON:0006915 ! stratified squamous epithelium intersection_of: BFO:0000051 GO:0045095 ! has part keratin filament relationship: BFO:0000051 GO:0045095 ! has part keratin filament [Term] id: UBERON:0012330 name: nasal-associated lymphoid tissue def: "The lymphocytic cell population present in the mucosa of the nasopharyngeal duct of some animals." [ncithesaurus:Nasal-Associated_Lymphoid_Tissue] synonym: "NALT" EXACT OMO:0003000 [Wikipedia:Mucosa-associated_lymphoid_tissue#Categorisation] synonym: "naso-pharyngeal lymphoid tissue" EXACT [FMA:79771] xref: FMA:79771 xref: MA:0003030 xref: NCIT:C77659 xref: UMLS:C2698431 {source="ncithesaurus:Nasal-Associated_Lymphoid_Tissue"} is_a: UBERON:0001962 ! gut-associated lymphoid tissue intersection_of: UBERON:0001961 ! mucosa-associated lymphoid tissue intersection_of: BFO:0000050 UBERON:0001728 ! part of nasopharynx relationship: BFO:0000050 UBERON:0001728 ! part of nasopharynx relationship: RO:0002131 UBERON:0005022 ! overlaps mucosa of nasopharynx [Term] id: UBERON:0012332 name: broad ligament of uterus def: "A broad fold of peritoneum that extends from the side of the uterus to the wall of the pelvis." [MESH:A02.513.170, Wikipedia:Broad_ligament_of_the_uterus] subset: human_reference_atlas synonym: "broad ligament" RELATED [MESH:A02.513.170] synonym: "broad uterine ligament" EXACT [FMA:16516] synonym: "ligamentum latum uteri" RELATED OMO:0003011 [] xref: FMA:16516 xref: MESH:D001956 xref: NCIT:C12318 xref: SCTID:362723009 xref: UMLS:C0006205 {source="ncithesaurus:Broad_Ligament"} xref: Wikipedia:Broad_ligament_of_the_uterus is_a: UBERON:0000211 {source="MESH"} ! ligament relationship: BFO:0000050 UBERON:0002095 ! part of mesentery relationship: RO:0002176 UBERON:0000459 ! connects uterine wall relationship: RO:0002176 UBERON:0002355 ! connects pelvic region of trunk property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0012344 name: holocrine gland def: "Any exocrine gland whose secretion consists of its own disintegrated secretory cells along with its secretory product; holocrine secretions are produced in the cytoplasm of the cell and released by the rupture of the plasma membrane, which destroys the cell and results in the secretion of the product into the lumen." [MP:0013543] subset: pheno_slim xref: BTO:0002325 xref: MA:0003042 xref: Wikipedia:Holocrine is_a: UBERON:0002365 {source="MA", source="MP"} ! exocrine gland [Term] id: UBERON:0012354 name: acropodium region def: "The segment of the autopod that is distal to the metapodial region and consists of the digits." [https://orcid.org/0000-0002-6601-2165] synonym: "acropodial limb segment" EXACT [] synonym: "acropodial region" EXACT [] synonym: "acropodial segment of autopod" EXACT [] synonym: "set of digits" EXACT [] is_a: UBERON:0012139 ! segment of autopod intersection_of: UBERON:0012139 ! segment of autopod intersection_of: RO:0002551 UBERON:0010543 ! has skeleton acropodial skeleton relationship: BFO:0000050 UBERON:0012140 ! part of digitopodium region relationship: BSPO:0000097 UBERON:0009877 ! metapodium region relationship: RO:0002551 UBERON:0010543 ! has skeleton acropodial skeleton [Term] id: UBERON:0012355 name: manual acropodium region def: "The segment of the manus that is distal to the metacarpal region and consists of the manual digits (fingers)." [https://orcid.org/0000-0002-6601-2165] synonym: "acropodial hindlimb segment" EXACT [] synonym: "acropodial region of manus" EXACT [] synonym: "acropodial segment of manus" EXACT [] synonym: "all fingers" EXACT [] synonym: "anterior acropodium" RELATED [] synonym: "anterior acropodium region" EXACT [] synonym: "anterior acropodium segment of limb" EXACT [] synonym: "digiti manus" EXACT [FMA:TA] synonym: "digits of hand" EXACT [FMA:75592] synonym: "fingers including thumb" EXACT [FMA:75592] synonym: "fingers set" EXACT [FMA:75592] synonym: "manual acropodium" RELATED [] synonym: "manual acropodium region" EXACT [] synonym: "manual acropodium segment of limb" EXACT [] synonym: "set of digits of hand" EXACT [FMA:75592] synonym: "set of fingers" EXACT [FMA:75592] xref: FMA:75592 is_a: UBERON:0005451 ! segment of manus is_a: UBERON:0012354 ! acropodium region intersection_of: UBERON:0012354 ! acropodium region intersection_of: BFO:0000050 UBERON:0002398 ! part of manus relationship: BFO:0000050 UBERON:0012141 ! part of manual digitopodium region relationship: RO:0002551 UBERON:0010688 ! has skeleton skeleton of manual acropodium [Term] id: UBERON:0012356 name: pedal acropodium region def: "The segment of the pes that is distal to the metatarsal region and consists of the pedal digits (toes)." [https://orcid.org/0000-0002-6601-2165] synonym: "acropodial forelimb segment" EXACT [] synonym: "acropodial region of pes" EXACT [] synonym: "acropodial segment of pes" EXACT [] synonym: "all toes" EXACT [] synonym: "digits of foot" EXACT [FMA:70664] synonym: "pedal acropodium region" EXACT [] synonym: "set of toes" EXACT [FMA:70664] synonym: "toes" RELATED [FMA:70664] synonym: "toes set" EXACT [FMA:70664] xref: FMA:70664 xref: SCTID:362835004 is_a: UBERON:0005445 ! segment of pes is_a: UBERON:0012354 ! acropodium region intersection_of: UBERON:0012354 ! acropodium region intersection_of: BFO:0000050 UBERON:0002387 ! part of pes relationship: BFO:0000050 UBERON:0012142 ! part of pedal digitopodium region relationship: RO:0002551 UBERON:0010696 ! has skeleton skeleton of pedal acropodium [Term] id: UBERON:0012357 name: digitopodium bone def: "A bone that is part of a the digitopodium skeleton - i.e. the acropodial skeleton or the metapodial skeleton." [https://orcid.org/0000-0002-6601-2165] synonym: "digit bone" RELATED COMPARATIVE_PREFERRED [] is_a: UBERON:0011250 ! autopod bone intersection_of: UBERON:0001474 ! bone element intersection_of: BFO:0000050 UBERON:0012140 ! part of digitopodium region relationship: BFO:0000050 UBERON:0012150 ! part of skeleton of digitopodium [Term] id: UBERON:0012358 name: manual digitopodium bone def: "A bone that is part of a the manual digitopodium skeleton - i.e. the fingers or the metacarpal skeleton." [https://orcid.org/0000-0002-6601-2165] synonym: "bone of forelimb digitopodium" EXACT [] xref: SCTID:265809008 is_a: UBERON:0005897 ! manus bone is_a: UBERON:0012357 ! digitopodium bone intersection_of: UBERON:0012357 ! digitopodium bone intersection_of: BFO:0000050 UBERON:0002398 ! part of manus relationship: BFO:0000050 UBERON:0012151 ! part of skeleton of manual digitopodium [Term] id: UBERON:0012359 name: pedal digitopodium bone def: "A bone that is part of a the pedal digitopodium skeleton - i.e. the toes or the metatarsal skeleton." [https://orcid.org/0000-0002-6601-2165] synonym: "bone of hindlimb digitopodium" EXACT [] is_a: UBERON:0005899 ! pes bone is_a: UBERON:0012357 ! digitopodium bone intersection_of: UBERON:0012357 ! digitopodium bone intersection_of: BFO:0000050 UBERON:0002387 ! part of pes relationship: BFO:0000050 UBERON:0012152 ! part of skeleton of pedal digitopodium [Term] id: UBERON:0012360 name: bone of jaw def: "A bone element that is part of a jaw region." [OBOL:automatic] synonym: "jaw bone" EXACT [] xref: EMAPA:35453 xref: MA:0003130 xref: SCTID:369003004 is_a: UBERON:0003462 ! facial bone is_a: UBERON:0013765 ! digestive system element intersection_of: UBERON:0001474 ! bone element intersection_of: BFO:0000050 UBERON:0011595 ! part of jaw region relationship: BFO:0000050 UBERON:0001708 ! part of jaw skeleton property_value: IAO:0000116 "Do not manually classify under here - bones are automatically classified" xsd:string property_value: skos:prefLabel "bone of jaw" xsd:string [Term] id: UBERON:0012361 name: internal anal region xref: EHDAA2:0004588 is_a: UBERON:0000481 ! multi-tissue structure relationship: BFO:0000050 UBERON:0001353 {source="EHDAA2"} ! part of anal region property_value: skos:prefLabel "internal anal region" xsd:string [Term] id: UBERON:0012363 name: thyroid follicle epithelium def: "An epithelium that is part of a thyroid follicle." [OBOL:automatic] synonym: "epithelium of thyroid follicle" EXACT [FMA:68783] synonym: "thryoid epithelium" BROAD [] synonym: "thyroid follicle epithelium" EXACT [FMA:68783] synonym: "wall of thyroid follicle" EXACT [FMA:68783] xref: FMA:68783 is_a: UBERON:0000484 {source="FMA"} ! simple cuboidal epithelium is_a: UBERON:0005911 ! endo-epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: BFO:0000050 UBERON:0005305 ! part of thyroid follicle relationship: BFO:0000050 UBERON:0005305 ! part of thyroid follicle relationship: RO:0002202 UBERON:0007689 ! develops from thyroid diverticulum [Term] id: UBERON:0012367 name: muscle layer of intestine def: "A muscle layer that is part of an intestine." [OBOL:automatic] synonym: "intestinal muscularis propria" EXACT [FMA:15697] synonym: "muscularis externa of intestine" EXACT [FMA:15697] synonym: "smooth muscle of intestine" RELATED [] xref: FMA:15697 is_a: UBERON:0018261 ! muscular coat of digestive tract intersection_of: UBERON:0006660 ! muscular coat intersection_of: BFO:0000050 UBERON:0000160 ! part of intestine relationship: BFO:0000050 UBERON:0001262 {source="FMA"} ! part of wall of intestine property_value: skos:prefLabel "muscle layer of intestine" xsd:string [Term] id: UBERON:0012368 name: circular muscle layer of muscular coat def: "The inner layer of the muscular coat." [BTO:0005213] synonym: "circular muscle layer" RELATED [] synonym: "circular smooth muscle" RELATED [BTO:0005213] synonym: "inner muscularis" RELATED [FMA:62899] synonym: "inner muscularis layer" RELATED [FMA:62899] xref: BTO:0005213 xref: FMA:62899 is_a: UBERON:0034933 ! layer of smooth muscle tissue relationship: BFO:0000050 UBERON:0006660 ! part of muscular coat [Term] id: UBERON:0012369 name: longitudinal muscle layer of muscular coat def: "The outer layer of the muscular coat." [BTO:0005214] synonym: "longitudinal muscle layer" RELATED [] synonym: "longitudinal smooth muscle" RELATED [BTO:0005214] synonym: "outer muscularis" RELATED [FMA:62900] synonym: "outer muscularis layer" RELATED [FMA:62900] xref: BTO:0005214 xref: FMA:62900 is_a: UBERON:0034933 ! layer of smooth muscle tissue relationship: BFO:0000050 UBERON:0006660 ! part of muscular coat [Term] id: UBERON:0012373 name: sympathetic nerve plexus def: "A nerve plexus that is part of a sympathetic nervous system." [OBOL:automatic] subset: human_reference_atlas xref: EMAPA:37617 {source="MA:th"} xref: MA:0001160 is_a: UBERON:0001816 ! autonomic nerve plexus intersection_of: UBERON:0001810 ! nerve plexus intersection_of: BFO:0000050 UBERON:0000013 ! part of sympathetic nervous system relationship: BFO:0000050 UBERON:0000013 ! part of sympathetic nervous system property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0012375 name: subserosa def: "A layer of tissue between the muscularis and serosa." [Wikipedia:Subserosa] comment: Contains nerves, blood vessels, lymphatics and lymph nodes subset: human_reference_atlas xref: FMA:45636 xref: NCIT:C94494 xref: SCTID:2255006 xref: UMLS:C0225334 {source="ncithesaurus:Subserosa"} xref: Wikipedia:Subserosa is_a: BFO:0000002 is_a: UBERON:0004923 ! organ component layer intersection_of: UBERON:0004923 ! organ component layer intersection_of: RO:0002220 UBERON:0000042 ! adjacent to serous membrane intersection_of: RO:0002473 UBERON:0006815 ! composed primarily of areolar connective tissue relationship: RO:0002162 NCBITaxon:7742 ! in taxon Vertebrata relationship: RO:0002220 UBERON:0000042 ! adjacent to serous membrane relationship: RO:0002473 UBERON:0006815 ! composed primarily of areolar connective tissue property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "subserosa" xsd:string [Term] id: UBERON:0012377 name: muscle layer of jejunum def: "A muscular coat that is part of a jejunum." [OBOL:automatic] subset: human_reference_atlas synonym: "jejunal smooth muscle" RELATED [https://orcid.org/0000-0002-6601-2165] synonym: "muscularis externa of jejunum" EXACT [FMA:14951] synonym: "muscularis propria of jejunum" RELATED [https://orcid.org/0000-0002-6601-2165] synonym: "smooth muscle of jejunum" RELATED [https://orcid.org/0000-0002-6601-2165] xref: FMA:14951 is_a: UBERON:0011201 ! muscle layer of small intestine intersection_of: UBERON:0006660 ! muscular coat intersection_of: BFO:0000050 UBERON:0002115 ! part of jejunum relationship: BFO:0000050 UBERON:0002115 ! part of jejunum property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0012378 name: muscle layer of urinary bladder def: "A muscular coat that is part of a urinary bladder." [OBOL:automatic] subset: human_reference_atlas synonym: "bladder muscular coat" EXACT [] synonym: "muscle layer of urinary bladder" EXACT [FMA:15930] synonym: "muscular coat of bladder" EXACT [FMA:15930] synonym: "muscular coat of urinary bladder" EXACT [FMA:15930] synonym: "muscular layer of bladder" EXACT [FMA:15930] synonym: "muscular layer of urinary bladder" EXACT [FMA:15930] synonym: "tunica musculari vesicae" EXACT [FMA:TA] synonym: "tunica muscularis (vesica urinaria)" EXACT [FMA:TA] xref: FMA:15930 xref: NCIT:C32206 xref: UMLS:C1288327 {source="ncithesaurus:Bladder_Muscular_Coat"} is_a: UBERON:0006660 ! muscular coat intersection_of: UBERON:0006660 ! muscular coat intersection_of: BFO:0000050 UBERON:0001255 ! part of urinary bladder relationship: BFO:0000050 UBERON:0001256 {source="FMA"} ! part of wall of urinary bladder relationship: BFO:0000051 UBERON:0004228 ! has part urinary bladder smooth muscle property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0012398 name: large intestine smooth muscle circular layer def: "A circular muscle layer of muscular coat that is part of a large intestine smooth muscle." [OBOL:automatic] subset: human_reference_atlas synonym: "circular muscle layer of segment of large intestine" RELATED [FMA:81160] xref: EMAPA:37558 {source="MA:th"} xref: FMA:81160 xref: MA:0001548 is_a: UBERON:0012368 ! circular muscle layer of muscular coat intersection_of: UBERON:0012368 ! circular muscle layer of muscular coat intersection_of: BFO:0000050 UBERON:0004220 ! part of large intestine smooth muscle relationship: BFO:0000050 UBERON:0004220 ! part of large intestine smooth muscle property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0012399 name: large intestine smooth muscle longitudinal layer def: "A longitudinal muscle layer of muscular coat that is part of a large intestine smooth muscle." [OBOL:automatic] subset: human_reference_atlas synonym: "longitudinal muscle layer of zone of large intestine" RELATED [FMA:63637] xref: EMAPA:37559 {source="MA:th"} xref: FMA:63637 xref: MA:0001549 is_a: UBERON:0012369 ! longitudinal muscle layer of muscular coat intersection_of: UBERON:0012369 ! longitudinal muscle layer of muscular coat intersection_of: BFO:0000050 UBERON:0004220 ! part of large intestine smooth muscle relationship: BFO:0000050 UBERON:0004220 ! part of large intestine smooth muscle property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0012401 name: small intestine smooth muscle circular layer def: "A circular muscle layer of muscular coat that is part of a small intestine smooth muscle." [OBOL:automatic] synonym: "circular layer of small intestine muscularis propria" EXACT [FMA:14935] synonym: "circular muscle coat of small intestine" EXACT [FMA:14935] synonym: "circular muscle layer of small intestine" EXACT [FMA:14935] synonym: "circular muscle of small intestine" EXACT [FMA:14935] synonym: "short pitch helicoidal muscle layer of small intestine" EXACT [FMA:14935] synonym: "stratum circulare (tunica muscularis)(intestinum tenue)" EXACT [FMA:14935] synonym: "stratum circulare tunicae muscularis intestini tenuis" EXACT OMO:0003011 [FMA:14935, FMA:TA] synonym: "stratum helicoidale brevis gradus tunicae muscularis intestini tenuis" EXACT [FMA:TA] xref: EMAPA:37562 {source="MA:th"} xref: FMA:14935 xref: MA:0001560 xref: SCTID:54658003 is_a: UBERON:0012368 ! circular muscle layer of muscular coat intersection_of: UBERON:0012368 ! circular muscle layer of muscular coat intersection_of: BFO:0000050 UBERON:0004239 ! part of small intestine smooth muscle relationship: BFO:0000050 UBERON:0004239 ! part of small intestine smooth muscle relationship: BFO:0000050 UBERON:0011201 {source="FMA"} ! part of muscle layer of small intestine [Term] id: UBERON:0012402 name: small intestine smooth muscle longitudinal layer def: "A longitudinal muscle layer of muscular coat that is part of a small intestine smooth muscle." [OBOL:automatic] synonym: "long pitch helicoidal muscle layer of small intestine" EXACT [FMA:14936] synonym: "longitudinal layer of small intestine muscularis propria" EXACT [FMA:14936] synonym: "longitudinal muscle coat of small intestine" EXACT [FMA:14936] synonym: "longitudinal muscle layer of small intestine" EXACT [FMA:14936] synonym: "longitudinal muscle of small intestine" EXACT [FMA:14936] synonym: "stratum helicoidale longi gradus tunicae muscularis intestini tenuis" EXACT [FMA:TA] synonym: "stratum longitudinale (tunica muscularis) (intestinum tenue)" EXACT [FMA:14936] synonym: "stratum longitudinale tunicae muscularis intestini tenuis" EXACT OMO:0003011 [FMA:14936, FMA:TA] xref: EMAPA:37563 {source="MA:th"} xref: FMA:14936 xref: MA:0001561 xref: SCTID:59150006 is_a: UBERON:0012369 ! longitudinal muscle layer of muscular coat intersection_of: UBERON:0012369 ! longitudinal muscle layer of muscular coat intersection_of: BFO:0000050 UBERON:0004239 ! part of small intestine smooth muscle relationship: BFO:0000050 UBERON:0004239 ! part of small intestine smooth muscle relationship: BFO:0000050 UBERON:0011201 {source="FMA"} ! part of muscle layer of small intestine [Term] id: UBERON:0012416 name: respiratory system arterial smooth muscle subset: human_reference_atlas xref: EMAPA:37567 {source="MA:th"} xref: MA:0001802 is_a: UBERON:0004297 ! respiratory system blood vessel smooth muscle is_a: UBERON:0004695 ! arterial system smooth muscle intersection_of: UBERON:0001135 ! smooth muscle tissue intersection_of: BFO:0000050 UBERON:0003643 ! part of respiratory system arterial blood vessel relationship: BFO:0000050 UBERON:0003643 ! part of respiratory system arterial blood vessel property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "respiratory system arterial smooth muscle" xsd:string [Term] id: UBERON:0012418 name: respiratory system venous smooth muscle def: "A smooth muscle tissue that is part of a respiratory system venous blood vessel." [OBOL:automatic] subset: human_reference_atlas xref: EMAPA:37586 {source="MA:th"} xref: MA:0001812 is_a: UBERON:0004696 ! venous system smooth muscle intersection_of: UBERON:0001135 ! smooth muscle tissue intersection_of: BFO:0000050 UBERON:0003476 ! part of respiratory system venous blood vessel relationship: BFO:0000050 UBERON:0003476 ! part of respiratory system venous blood vessel property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "respiratory system venous smooth muscle" xsd:string [Term] id: UBERON:0012419 name: taenia coli def: "The taeniae coli (also teniae coli) are three separate longitudinal ribbons of smooth muscle on the outside of the ascending, transverse, descending and sigmoid colons. They are visible, and can be seen just below the serosa or fibrosa. They are the Mesocolic, Free and Omental Coli. The teniae coli contracts length wise to produce the haustra, the bulges in the colon. The bands converge at the root of the vermiform appendix and the rectum. These bands correspond to the outer layer of the muscularis externa, in other portions of the digestive tract." [Wikipedia:Taenia_coli] subset: human_reference_atlas synonym: "longitudinal band of large intestine muscularis" EXACT [FMA:15041] synonym: "longitudinal bands" RELATED [Wikipedia:Taenia_coli] synonym: "taeniae coli" RELATED [Wikipedia:Taenia_coli] synonym: "tenia coli" RELATED [Wikipedia:Taenia_coli] synonym: "teniae coli" RELATED [Wikipedia:Taenia_coli] xref: FMA:15041 xref: SCTID:362160001 xref: Wikipedia:Taenia_coli is_a: UBERON:0034933 ! layer of smooth muscle tissue relationship: BFO:0000050 UBERON:0011198 {source="FMA"} ! part of muscle layer of large intestine property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0012423 name: layer of microvilli def: "A layer of microvilli, Thin cylindrical membrane-covered projections on the surface of an animal cell containing a core bundle of actin filaments[GO,modified]." [GO:0005902, Wikipedia:Microvillus] synonym: "microvilli" RELATED [MESH:A11.284.180.565] synonym: "microvillus" RELATED [FMA:67296] xref: FMA:67296 xref: MESH:D008871 xref: NCIT:C33112 xref: UMLS:C0026049 {source="ncithesaurus:Microvillus"} xref: Wikipedia:Microvillus is_a: UBERON:0005162 ! multi cell part structure relationship: RO:0002473 GO:0005902 ! composed primarily of microvillus property_value: skos:prefLabel "layer of microvilli" xsd:string [Term] id: UBERON:0012425 name: striated border microvillus layer def: "A microvillus layer that is striated and found in the intestine." [http://medical-dictionary.thefreedictionary.com/striated+border, http://orcid.org/0000-0002-6601-2165] synonym: "striated border" RELATED [FMA:70978] xref: FMA:70978 xref: NCIT:C33634 is_a: UBERON:0012423 ! layer of microvilli relationship: BFO:0000050 UBERON:0000160 ! part of intestine property_value: skos:prefLabel "striated border microvillus layer" xsd:string [Term] id: UBERON:0012429 name: hematopoietic tissue def: "Blood-forming tissue, consisting of reticular fibers and cells." [http://encyclopedia2.thefreedictionary.com/hematopoietic+tissue] synonym: "bone marrow tissue" NARROW [NCBITaxon:9606] synonym: "haemopoietic tissue" EXACT [FMA:14073] synonym: "hematopoietic tissue" EXACT [FMA:14073] synonym: "hemopoietic tissue" EXACT [FMA:14073] synonym: "textus haemopoieticus" EXACT [FMA:14073] xref: CALOHA:TS-2142 xref: FMA:14073 xref: NCIT:C13051 xref: UMLS:C0229619 {source="ncithesaurus:Hematopoietic_Tissue"} is_a: UBERON:0034769 {source="FMA"} ! lymphomyeloid tissue intersection_of: UBERON:0000479 ! tissue intersection_of: site_of GO:0030097 ! hemopoiesis relationship: BFO:0000050 UBERON:0002390 {source="defitional"} ! part of hematopoietic system relationship: site_of GO:0030097 ! hemopoiesis [Term] id: UBERON:0012430 name: tunica fibrosa of eyeball def: "The sclera and cornea form the fibrous tunic of the bulb of the eye; the sclera is opaque, and constitutes the posterior five-sixths of the tunic; the cornea is transparent, and forms the anterior sixth." [Wikipedia:Fibrous_tunic_of_eyeball] synonym: "corneosclera" RELATED [Wikipedia:Fibrous_tunic_of_eyeball] synonym: "fibrous layer of eyeball" EXACT [FMA:58102] synonym: "fibrous tunic" RELATED [Wikipedia:Fibrous_tunic_of_eyeball] synonym: "tunica fibrosa" BROAD [] xref: FMA:58102 xref: SCTID:361318005 xref: Wikipedia:Fibrous_tunic_of_eyeball is_a: UBERON:0004923 {source="FMA"} ! organ component layer is_a: UBERON:0010314 ! structure with developmental contribution from neural crest relationship: BFO:0000050 UBERON:0010230 ! part of eyeball of camera-type eye relationship: BFO:0000051 UBERON:0000964 ! has part cornea relationship: BFO:0000051 UBERON:0001773 ! has part sclera property_value: RO:0002175 NCBITaxon:7955 {source="DOI:10.1177/0192623311409597"} property_value: skos:prefLabel "tunica fibrosa of eyeball" xsd:string [Term] id: UBERON:0012441 name: endothelium of peritubular capillary def: "An endothelium that is part of a peritubular capillary." [OBOL:automatic] subset: human_reference_atlas synonym: "peritubular capillary endothelium" EXACT [] synonym: "peritubular endothelium" BROAD [] is_a: UBERON:0001915 ! endothelium of capillary is_a: UBERON:0004819 ! kidney epithelium intersection_of: UBERON:0001986 ! endothelium intersection_of: BFO:0000050 UBERON:0005272 ! part of peritubular capillary relationship: BFO:0000050 UBERON:0005272 ! part of peritubular capillary property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0012463 name: cloacal lumen def: "An anatomical space that is enclosed by a cloaca." [OBOL:automatic] synonym: "cloaca lumen" EXACT [ZFA:0000330] synonym: "cloacal chamber" EXACT [ZFA:0000330] xref: TAO:0000330 xref: ZFA:0000330 is_a: UBERON:0000464 ! anatomical space intersection_of: UBERON:0000464 ! anatomical space intersection_of: RO:0002572 UBERON:0000162 ! luminal space of cloaca relationship: BFO:0000050 UBERON:0012465 {source="cjm"} ! part of lumen of terminal part of digestive tract relationship: RO:0002572 UBERON:0000162 ! luminal space of cloaca property_value: skos:prefLabel "cloacal lumen" xsd:string [Term] id: UBERON:0012464 name: cloacal vent def: "The opening of the cloacal chamber to the outside of the organism. Birds maintain a single cloacal opening throughout their lives." [http://orcid.org/0000-0002-6601-2165] synonym: "cloacal opening" EXACT [] synonym: "cloacal orifice" RELATED [] synonym: "vent" RELATED [] is_a: UBERON:0000161 ! orifice intersection_of: UBERON:0000161 ! orifice intersection_of: BFO:0000050 UBERON:0000162 ! part of cloaca relationship: BFO:0000050 UBERON:0000162 ! part of cloaca property_value: skos:prefLabel "cloacal vent" xsd:string [Term] id: UBERON:0012465 name: lumen of terminal part of digestive tract def: "An anatomical space that is enclosed by a terminal part of digestive tract." [OBOL:automatic] is_a: UBERON:0000464 ! anatomical space intersection_of: UBERON:0000464 ! anatomical space intersection_of: RO:0002572 UBERON:0006866 ! luminal space of terminal part of digestive tract relationship: RO:0002572 UBERON:0006866 ! luminal space of terminal part of digestive tract property_value: skos:prefLabel "lumen of terminal part of digestive tract" xsd:string [Term] id: UBERON:0012466 name: extraembryonic cavity synonym: "extraembryonic cavities" RELATED OMO:0003004 [EHDAA2:0000472] xref: EHDAA2:0000472 xref: EMAPA:16054 xref: VHOG:0000767 is_a: UBERON:0000464 ! anatomical space intersection_of: UBERON:0000464 ! anatomical space intersection_of: BFO:0000050 UBERON:0016887 ! part of entire extraembryonic component relationship: BFO:0000050 UBERON:0016887 ! part of entire extraembryonic component property_value: skos:prefLabel "extraembryonic cavity" xsd:string [Term] id: UBERON:0012467 name: enclosed anatomical space def: "An anatomical space with no opening to another space or to the exterior." [AEO:0000222] synonym: "closed anatomical space" EXACT [] xref: AEO:0000222 is_a: UBERON:0000464 ! anatomical space intersection_of: UBERON:0000464 ! anatomical space intersection_of: RO:0000086 PATO:0000608 ! has quality closed relationship: RO:0000086 PATO:0000608 ! has quality closed property_value: skos:prefLabel "enclosed anatomical space" xsd:string [Term] id: UBERON:0012468 name: anal tooth def: "Triangular calcified papillae (often five) placed radially around the anus of some Holothuriidae." [http://species-identification.org/species.php?species_group=nasc&selected=definitie&menuentry=woordenlijst&record=Anal%20teeth, https://orcid.org/0000-0002-6601-2165, https://www.karger.com/Article/Pdf/142845] synonym: "anal teeth" EXACT OMO:0003004 [] synonym: "calcified anal papilla" RELATED [] synonym: "cloacal tooth" RELATED [] synonym: "perianal tooth" RELATED [] is_a: UBERON:0003913 ! tooth-like structure intersection_of: UBERON:0003913 ! tooth-like structure intersection_of: BFO:0000050 UBERON:0001353 ! part of anal region relationship: BFO:0000050 UBERON:0001353 ! part of anal region relationship: RO:0002162 NCBITaxon:7586 ! in taxon Echinodermata [Term] id: UBERON:0012469 name: external anal region xref: EHDAA2:0004589 is_a: UBERON:0000481 ! multi-tissue structure relationship: BFO:0000050 UBERON:0001353 {source="EHDAA2"} ! part of anal region property_value: skos:prefLabel "external anal region" xsd:string [Term] id: UBERON:0012475 name: skeleton of pectoral complex def: "The collection of all skeletal elements in a pectoral complex - i.e. the combination of free limb or fin plus pectoral girdle." [https://orcid.org/0000-0002-6601-2165] subset: pheno_slim synonym: "bones of upper limb" RELATED [FMA:24139] synonym: "ossa membri superioris" RELATED [FMA:TA] synonym: "pectoral complex skeleton" RELATED [https://orcid.org/0000-0002-6601-2165] synonym: "set of bones of upper limb" RELATED [FMA:24139] synonym: "skeleton of anterior limb/fin and girdle" RELATED [https://orcid.org/0000-0002-6601-2165] synonym: "upper limb skeleton" RELATED [FMA:24139] xref: FMA:24139 is_a: UBERON:0010912 ! subdivision of skeleton intersection_of: UBERON:0010912 ! subdivision of skeleton intersection_of: RO:0002576 UBERON:0010708 ! skeleton of pectoral complex relationship: BFO:0000050 UBERON:0002091 ! part of appendicular skeleton relationship: RO:0002576 UBERON:0010708 ! skeleton of pectoral complex property_value: skos:prefLabel "skeleton of pectoral complex" xsd:string [Term] id: UBERON:0012476 name: skeleton of pelvic complex def: "The collection of all skeletal elements in a pelvic complex - i.e. the combination of free limb or fin plus pelvic girdle." [https://orcid.org/0000-0002-6601-2165] subset: pheno_slim synonym: "bones of lower limb" RELATED [FMA:24140] synonym: "lower limb skeleton" RELATED [FMA:24140] synonym: "ossa membri inferioris" RELATED [FMA:TA] synonym: "pelvic complex skeleton" RELATED [https://orcid.org/0000-0002-6601-2165] synonym: "set of bones of lower limb" RELATED [FMA:24140] synonym: "skeleton of posterior limb/fin and girdle" RELATED [https://orcid.org/0000-0002-6601-2165] xref: FMA:24140 is_a: UBERON:0010912 ! subdivision of skeleton intersection_of: UBERON:0010912 ! subdivision of skeleton intersection_of: RO:0002576 UBERON:0010709 ! skeleton of pelvic complex relationship: BFO:0000050 UBERON:0002091 ! part of appendicular skeleton relationship: RO:0002576 UBERON:0010709 ! skeleton of pelvic complex [Term] id: UBERON:0012477 name: dorsal part of neck def: "The posterior region of the neck, including the suboccipital region." [MP:0012723] subset: pheno_slim synonym: "back of neck" EXACT [FMA:24189] synonym: "hindneck" RELATED [] synonym: "nape" BROAD [BTO:0000957] synonym: "nape of neck" EXACT [] synonym: "neck back" EXACT [FMA:24189] synonym: "nucha" EXACT [FMA:24189] synonym: "nuchal region" EXACT [FMA:24189] synonym: "posterior cervical region" EXACT [FMA:24189] synonym: "posterior neck region" EXACT [FMA:24189] synonym: "posterior part of neck" EXACT [FMA:24189] synonym: "regio cervicalis posterior" EXACT [FMA:TA] xref: BTO:0000957 xref: FMA:24189 xref: SCTID:182326009 xref: SCTID:304036007 is_a: UBERON:0005434 {source="FMA"} ! cervical region relationship: BFO:0000050 UBERON:0001137 {source="FMA"} ! part of dorsum relationship: BSPO:0015101 UBERON:0000974 {source="FMA"} ! neck property_value: skos:prefLabel "dorsal part of neck" xsd:string [Term] id: UBERON:0012478 name: cloacal gland def: "A gland that is part of a cloaca." [OBOL:automatic] is_a: UBERON:0003408 ! gland of digestive tract intersection_of: UBERON:0002530 ! gland intersection_of: BFO:0000050 UBERON:0000162 ! part of cloaca relationship: BFO:0000050 UBERON:0000162 ! part of cloaca property_value: skos:prefLabel "cloacal gland" xsd:string [Term] id: UBERON:0012480 name: cloacal mucosa def: "A mucosa that is part of a cloaca [Automatically generated definition]." [OBOL:automatic] synonym: "cloaca mucosa" EXACT [] synonym: "cloaca mucosa of organ" EXACT [] synonym: "cloaca mucous membrane" EXACT [] synonym: "cloaca organ mucosa" EXACT [] synonym: "cloacal mucous membrane" EXACT [] synonym: "mucosa of cloaca" EXACT [] synonym: "mucosa of organ of cloaca" EXACT [] synonym: "mucous membrane of cloaca" EXACT [] synonym: "organ mucosa of cloaca" EXACT [] is_a: UBERON:0000344 ! mucosa intersection_of: UBERON:0000344 ! mucosa intersection_of: BFO:0000050 UBERON:0000162 ! part of cloaca relationship: BFO:0000050 UBERON:0000162 ! part of cloaca property_value: skos:prefLabel "cloacal mucosa" xsd:string [Term] id: UBERON:0012481 name: cloacal epithelium def: "An epithelium that is part of a cloaca." [http://orcid.org/0000-0002-6601-2165] synonym: "cloacal endoderm" RELATED [EMAPA:27577] xref: EMAPA:27577 xref: EMAPA:36070 xref: ZFA:0005783 is_a: UBERON:0003929 ! digestive tract epithelium is_a: UBERON:0005911 ! endo-epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: BFO:0000050 UBERON:0000162 ! part of cloaca relationship: BFO:0000050 UBERON:0000162 ! part of cloaca property_value: skos:prefLabel "cloacal epithelium" xsd:string [Term] id: UBERON:0012482 name: submucosa of cloaca def: "A submucosa that is part of a cloaca [Automatically generated definition]." [OBOL:automatic] synonym: "cloaca submucosa" EXACT [] synonym: "cloacal submucosa" EXACT [] is_a: UBERON:0018257 ! submucosa of digestive tract intersection_of: UBERON:0000009 ! submucosa intersection_of: BFO:0000050 UBERON:0000162 ! part of cloaca relationship: BFO:0000050 UBERON:0000162 ! part of cloaca property_value: skos:prefLabel "submucosa of cloaca" xsd:string [Term] id: UBERON:0012483 name: serosa of cloaca def: "A serous membrane that is part of a cloaca [Automatically generated definition]." [OBOL:automatic] synonym: "cloaca serosa" EXACT [] synonym: "cloaca serous membrane" EXACT [] synonym: "cloacal serosa" EXACT [] synonym: "serous membrane of cloaca" EXACT [] synonym: "visceral peritoneum of cloaca" EXACT [] is_a: UBERON:0000042 ! serous membrane intersection_of: UBERON:0000042 ! serous membrane intersection_of: BFO:0000050 UBERON:0000162 ! part of cloaca relationship: BFO:0000050 UBERON:0000162 ! part of cloaca property_value: skos:prefLabel "serosa of cloaca" xsd:string [Term] id: UBERON:0012485 name: cloacal villus synonym: "cloacal villi" EXACT OMO:0003004 [] is_a: UBERON:0012423 ! layer of microvilli intersection_of: UBERON:0012423 ! layer of microvilli intersection_of: BFO:0000050 UBERON:0000162 ! part of cloaca relationship: BFO:0000050 UBERON:0000162 ! part of cloaca property_value: skos:prefLabel "cloacal villus" xsd:string [Term] id: UBERON:0012486 name: muscle layer of cloaca def: "A muscular coat that is part of a cloaca." [OBOL:automatic] synonym: "muscularis externa of cloaca" EXACT [] synonym: "smooth muscle of cloaca" RELATED [] is_a: UBERON:0018261 ! muscular coat of digestive tract intersection_of: UBERON:0006660 ! muscular coat intersection_of: BFO:0000050 UBERON:0000162 ! part of cloaca relationship: BFO:0000050 UBERON:0000162 ! part of cloaca property_value: skos:prefLabel "muscle layer of cloaca" xsd:string [Term] id: UBERON:0012487 name: vaginal sphincter def: "A sphincter muscle that is part of a vagina." [OBOL:automatic] synonym: "sphincter of vagina" EXACT [] is_a: UBERON:0004590 ! sphincter muscle is_a: UBERON:0005156 ! reproductive structure intersection_of: UBERON:0004590 ! sphincter muscle intersection_of: BFO:0000050 UBERON:0000996 ! part of vagina relationship: BFO:0000050 UBERON:0000996 ! part of vagina property_value: RO:0002161 NCBITaxon:9606 property_value: RO:0002175 NCBITaxon:8509 [Term] id: UBERON:0012488 name: muscle layer of duodenum def: "A muscular coat that is part of a duodenum." [OBOL:automatic] synonym: "duodenal muscularis propria" EXACT [FMA:14944] synonym: "muscularis externa of duodenum" EXACT [FMA:14944] synonym: "muscularis propria of duodenum" RELATED [https://orcid.org/0000-0002-6601-2165] synonym: "smooth muscle of duodenum" RELATED [https://orcid.org/0000-0002-6601-2165] xref: FMA:14944 xref: SCTID:362147007 is_a: UBERON:0011201 ! muscle layer of small intestine intersection_of: UBERON:0006660 ! muscular coat intersection_of: BFO:0000050 UBERON:0002114 ! part of duodenum relationship: BFO:0000050 UBERON:0002114 ! part of duodenum property_value: skos:prefLabel "muscle layer of duodenum" xsd:string [Term] id: UBERON:0012489 name: muscle layer of colon def: "A muscular coat that is part of a colon." [OBOL:automatic] subset: human_reference_atlas synonym: "colon muscularis" RELATED [MA:0003198] synonym: "colonic muscularis propria" EXACT [FMA:14986] synonym: "muscular coat of colon" EXACT [FMA:14986] synonym: "muscular layer of colon" EXACT [FMA:14986] synonym: "muscularis externa of colon" EXACT [FMA:14986] synonym: "tunica muscularis coli" EXACT [FMA:TA] xref: EMAPA:27383 xref: FMA:14986 xref: MA:0003198 xref: SCTID:362158003 is_a: UBERON:0011198 ! muscle layer of large intestine intersection_of: UBERON:0006660 ! muscular coat intersection_of: BFO:0000050 UBERON:0001155 ! part of colon relationship: BFO:0000050 UBERON:0001155 ! part of colon property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "muscle layer of colon" xsd:string [Term] id: UBERON:0012490 name: muscle layer of anal canal def: "A muscular coat that is part of a anal canal." [OBOL:automatic] synonym: "anal canal muscularis propria" EXACT [] synonym: "anal muscularis propria" EXACT [FMA:15708] synonym: "muscular coat of anal canal" EXACT [] synonym: "muscular layer of anal canal" EXACT [] synonym: "muscularis externa of anal canal" EXACT [] synonym: "muscularis propria of anal canal" EXACT [FMA:15708] xref: FMA:15708 xref: SCTID:362171000 is_a: UBERON:0011198 ! muscle layer of large intestine intersection_of: UBERON:0006660 ! muscular coat intersection_of: BFO:0000050 UBERON:0000159 ! part of anal canal relationship: BFO:0000050 UBERON:0000159 ! part of anal canal property_value: skos:prefLabel "muscle layer of anal canal" xsd:string [Term] id: UBERON:0012494 name: muscularis mucosae of duodenum def: "A muscularis mucosa that is part of a duodenum." [OBOL:automatic] subset: human_reference_atlas synonym: "lamina muscularis of duodenal mucous membrane" EXACT [FMA:15059] synonym: "lamina muscularis of duodenum" EXACT [] xref: EMAPA:27243 xref: EMAPA:27259 xref: FMA:15059 xref: MA:0003210 xref: MA:0003211 xref: SCTID:37457002 is_a: UBERON:0001210 ! muscularis mucosae of small intestine intersection_of: UBERON:0006676 ! muscularis mucosa intersection_of: BFO:0000050 UBERON:0002114 ! part of duodenum relationship: BFO:0000050 UBERON:0000320 {source="FMA"} ! part of duodenal mucosa property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0012497 name: muscularis mucosae of rectum def: "A muscularis mucosa that is part of a rectum." [OBOL:automatic] synonym: "lamina muscularis of rectal mucosa" EXACT [FMA:15687] synonym: "lamina muscularis of rectal mucous membrane" EXACT [FMA:15687] xref: EMAPA:27093 xref: FMA:15687 xref: SCTID:53420003 is_a: UBERON:0001239 ! muscularis mucosae of large intestine is_a: UBERON:0018112 ! rectum smooth muscle tissue intersection_of: UBERON:0006676 ! muscularis mucosa intersection_of: BFO:0000050 UBERON:0001052 ! part of rectum relationship: BFO:0000050 UBERON:0003346 {source="FMA"} ! part of mucosa of rectum [Term] id: UBERON:0012498 name: serosa of appendix def: "A serous membrane that is part of a vermiform appendix." [OBOL:automatic] subset: human_reference_atlas synonym: "appendiceal serosa" EXACT [FMA:14997] synonym: "appendix serosa" EXACT [FMA:14997] synonym: "serosa of vermiform appendix" EXACT [FMA:14997] synonym: "visceral peritoneum of vermiform appendix" EXACT [FMA:14997] xref: FMA:14997 xref: SCTID:22488003 is_a: UBERON:0001209 ! serosa of large intestine intersection_of: UBERON:0000042 ! serous membrane intersection_of: BFO:0000050 UBERON:0001154 ! part of vermiform appendix relationship: BFO:0000050 UBERON:0001154 ! part of vermiform appendix property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0012499 name: serosa of fallopian tube def: "A serous membrane that is part of a fallopian tube." [OBOL:automatic] synonym: "serosa of oviduct" EXACT [FMA:18316] synonym: "serosa of uterine tube" EXACT [] synonym: "serous coat of uterine tube" EXACT [FMA:18316] synonym: "tunica serosa (tuba uterina)" EXACT [FMA:18316] synonym: "tunica serosa tubae uterinae" EXACT [FMA:TA] synonym: "uterine tubal serosa" EXACT [FMA:18316] synonym: "uterine tube serosa" EXACT [FMA:18316] xref: FMA:18316 xref: SCTID:259593000 is_a: UBERON:0000042 ! serous membrane is_a: UBERON:0005156 ! reproductive structure intersection_of: UBERON:0000042 ! serous membrane intersection_of: BFO:0000050 UBERON:0003889 ! part of fallopian tube relationship: BFO:0000050 UBERON:0003889 ! part of fallopian tube [Term] id: UBERON:0012503 name: serosa of fundus of stomach def: "A serous membrane that is part of a fundus of stomach." [OBOL:automatic] synonym: "visceral peritoneum of fundus of stomach" EXACT [FMA:17073] xref: EMAPA:27157 xref: FMA:17073 is_a: UBERON:0001201 ! serosa of stomach intersection_of: UBERON:0000042 ! serous membrane intersection_of: BFO:0000050 UBERON:0001160 ! part of fundus of stomach relationship: BFO:0000050 UBERON:0001160 ! part of fundus of stomach relationship: BFO:0000050 UBERON:0001201 {source="FMA"} ! part of serosa of stomach [Term] id: UBERON:0012504 name: adventitia of esophagus def: "An adventitia that is part of a esophagus." [OBOL:automatic] synonym: "adventitia of oesophagus" EXACT [FMA:63006] synonym: "adventitious layer of esophagus" EXACT [FMA:63006] synonym: "esophageal adventitia" EXACT [FMA:63006] synonym: "esophagus adventitia" EXACT [FMA:63006] synonym: "tunica adventitia (esophagus)" EXACT [FMA:63006] synonym: "tunica adventitia oesophageae" EXACT [FMA:TA] xref: FMA:63006 xref: SCTID:85950006 is_a: UBERON:0005742 ! adventitia intersection_of: UBERON:0005742 ! adventitia intersection_of: BFO:0000050 UBERON:0001043 ! part of esophagus relationship: BFO:0000050 UBERON:0001043 ! part of esophagus property_value: skos:prefLabel "adventitia of esophagus" xsd:string [Term] id: UBERON:0012615 name: umbilical smooth muscle def: "A smooth muscle tissue that is part of a umbilical cord." [OBOL:automatic] xref: BTO:0001847 is_a: UBERON:0001135 ! smooth muscle tissue is_a: UBERON:0005292 ! extraembryonic tissue intersection_of: UBERON:0001135 ! smooth muscle tissue intersection_of: BFO:0000050 UBERON:0002331 ! part of umbilical cord relationship: BFO:0000050 UBERON:0002331 ! part of umbilical cord [Term] id: UBERON:0012650 name: gastroduodenal junction def: "An anatomical junction that connects a stomach and connects a duodenum." [OBOL:automatic] xref: FMA:17046 xref: SCTID:264014000 is_a: UBERON:1100000 ! digestive tract junction intersection_of: UBERON:0007651 ! anatomical junction intersection_of: RO:0002176 UBERON:0000945 ! connects stomach intersection_of: RO:0002176 UBERON:0002114 ! connects duodenum relationship: BFO:0000050 UBERON:0000945 ! part of stomach relationship: RO:0002176 UBERON:0000945 ! connects stomach relationship: RO:0002176 UBERON:0002114 ! connects duodenum property_value: skos:prefLabel "gastroduodenal junction" xsd:string [Term] id: UBERON:0012651 name: mucosa of gastroduodenal junction def: "A mucosa that is part of a gastroduodenal junction." [OBOL:automatic] synonym: "gastroduodenal mucosa" EXACT [BTO:0005415] xref: BTO:0005415 is_a: UBERON:0001199 ! mucosa of stomach intersection_of: UBERON:0000344 ! mucosa intersection_of: BFO:0000050 UBERON:0012650 ! part of gastroduodenal junction relationship: BFO:0000050 UBERON:0001199 ! part of mucosa of stomach relationship: BFO:0000050 UBERON:0012650 ! part of gastroduodenal junction property_value: skos:prefLabel "mucosa of gastroduodenal junction" xsd:string [Term] id: UBERON:0013118 name: sulcus of brain def: "A depression or fissure in the surface of the brain. It surrounds the gyri, creating the characteristic appearance of the brain in humans and other large mammals." [https://github.com/obophenotype/uberon/issues/315, Wikipedia:Sulcus_(neuroanatomy)] subset: cumbo synonym: "cerebral sulci" EXACT OMO:0003004 [DHBA:10610] synonym: "cerebral sulci" RELATED [NeuroNames:1208] synonym: "cerebral sulcus" RELATED [NeuroNames:1208] synonym: "fissure of brain" NARROW [Wikipedia:Sulcus_(neuroanatomy)] synonym: "sulci & spaces" BROAD OMO:0003004 [HBA:9352] synonym: "sulcus" BROAD [NLX:144078] xref: DHBA:10610 xref: HBA:9352 xref: NCIT:C32292 xref: neuronames:1208 xref: SCTID:279337001 xref: Wikipedia:Sulcus_(neuroanatomy) is_a: UBERON:0000093 ! sulcus intersection_of: UBERON:0000093 ! sulcus intersection_of: BFO:0000050 UBERON:0000955 ! part of brain relationship: BFO:0000050 UBERON:0000955 ! part of brain relationship: RO:0002162 NCBITaxon:40674 ! in taxon Mammalia relationship: RO:0002221 UBERON:0000200 ! surrounds gyrus property_value: IAO:0000116 "sulci are considered absent from lissencephalic mammals such as mice, but they may possess fissures. For example, the Allen mouse brain Atlas includes hippocampal, rhinal and choroid fissure. For this reason we do not place a taxon constraint on this class" xsd:string property_value: skos:prefLabel "sulcus of brain" xsd:string [Term] id: UBERON:0013121 name: proximal epiphysis of phalanx of pes synonym: "basal epiphysis of phalanx of foot" EXACT [FMA:32888] synonym: "base of phalanx of foot" EXACT [FMA:32888] synonym: "basis phalangis (pedis)" EXACT [FMA:32888] synonym: "basis phalangis pedis" EXACT [FMA:TA] synonym: "proximal epiphysis of phalanx of toe" EXACT [FMA:32888] xref: FMA:32888 is_a: UBERON:0004447 ! proximal epiphysis of phalanx is_a: UBERON:0011973 ! epiphysis of phalanx of pes intersection_of: UBERON:0004380 ! proximal epiphysis intersection_of: BFO:0000050 UBERON:0001449 ! part of phalanx of pes relationship: BFO:0000050 UBERON:0001449 ! part of phalanx of pes [Term] id: UBERON:0013126 name: vein of abdomen def: "A vein that is part of a abdomen." [OBOL:automatic] subset: grouping_class synonym: "abdominal vein" EXACT [] xref: SCTID:281473003 is_a: UBERON:0001638 ! vein is_a: UBERON:0003497 ! abdomen blood vessel intersection_of: UBERON:0001638 ! vein intersection_of: BFO:0000050 UBERON:0000916 ! part of abdomen property_value: IAO:0000116 "TODO mirror representation of abdominal aorta" xsd:string property_value: skos:prefLabel "vein of abdomen" xsd:string [Term] id: UBERON:0013127 name: pulmonary venous system def: "The part of the venous system that drains the lungs[Kardong]." [ISBN:0073040584, Wikipedia:Pulmonary_venous_system] synonym: "pulmonary venous circulatory system" EXACT [] xref: Wikipedia:Pulmonary_venous_system is_a: UBERON:0002049 ! vasculature relationship: BFO:0000050 UBERON:0004582 ! part of venous system relationship: channels_from UBERON:0000102 ! lung vasculature property_value: skos:prefLabel "pulmonary venous system" xsd:string [Term] id: UBERON:0013136 name: vein of lip def: "A vein that drains a lip." [OBOL:automatic] synonym: "labial vein" RELATED [] synonym: "labial vein of face" EXACT [] synonym: "lip vein" EXACT [OBOL:automatic] synonym: "vena labialis" EXACT OMO:0003011 [] xref: SCTID:367664002 is_a: UBERON:0001638 ! vein intersection_of: UBERON:0001638 ! vein intersection_of: RO:0020102 UBERON:0001833 ! vessel drains blood from lip relationship: RO:0002376 UBERON:0001653 {source="FMA"} ! tributary of facial vein relationship: RO:0020102 UBERON:0001833 ! vessel drains blood from lip property_value: skos:prefLabel "vein of lip" xsd:string [Term] id: UBERON:0013139 name: ligament of liver def: "A nonskeletal ligament that is part of a liver." [OBOL:automatic] synonym: "hepatic ligament" EXACT [FMA:15820] synonym: "liver ligament" EXACT [] xref: FMA:15820 xref: NCIT:C32997 xref: SCTID:48536008 xref: UMLS:C0230238 {source="ncithesaurus:Liver_Ligament"} is_a: UBERON:0005172 ! abdomen element is_a: UBERON:0008845 ! nonskeletal ligament is_a: UBERON:0013765 ! digestive system element intersection_of: UBERON:0008845 ! nonskeletal ligament intersection_of: BFO:0000050 UBERON:0002107 ! part of liver relationship: BFO:0000050 UBERON:0002107 ! part of liver [Term] id: UBERON:0013140 name: systemic vein def: "Any vein within the general circulation that transports blood back to the right atrium of the heart." [ncithesaurus:Systemic_Vein] synonym: "systemic venous tree organ part" EXACT [FMA:66644] xref: FMA:66644 xref: NCIT:C33719 xref: SCTID:244389004 xref: UMLS:C0447117 {source="ncithesaurus:Systemic_Vein"} is_a: UBERON:0001638 ! vein intersection_of: UBERON:0001638 ! vein intersection_of: BFO:0000050 UBERON:0004581 ! part of systemic venous system relationship: BFO:0000050 UBERON:0004581 ! part of systemic venous system property_value: skos:prefLabel "systemic vein" xsd:string [Term] id: UBERON:0013149 name: hindbrain vesicle comment: gives rise of 4th ventricle synonym: "rhombencephalic vesicle" EXACT [EHDAA2:0000101] xref: EHDAA2:0000101 xref: SCTID:361482003 is_a: UBERON:0013150 ! future brain vesicle relationship: BFO:0000050 UBERON:0007277 {source="EHDAA2"} ! part of presumptive hindbrain property_value: skos:prefLabel "hindbrain vesicle" xsd:string [Term] id: UBERON:0013150 name: future brain vesicle synonym: "brain vesicle" RELATED [] synonym: "early brain vesicle" EXACT [] synonym: "primary brain vesicle" NARROW [] synonym: "primitive brain vesicle" EXACT [] synonym: "secondary brain vesicle" NARROW [] xref: NCIT:C34259 xref: neuronames:2499 xref: SCTID:360409004 is_a: UBERON:0010000 ! multicellular anatomical structure relationship: BFO:0000050 UBERON:0005281 {source="EHDAA2"} ! part of ventricular system of central nervous system relationship: BFO:0000050 UBERON:0006238 ! part of future brain property_value: IAO:0000116 "consider adding all secondary vesicles (e.g. diencephalic; my/metencephalic. See http://www.dartmouth.edu/~rswenson/NeuroSci/chapter_4.html)." xsd:string property_value: skos:prefLabel "future brain vesicle" xsd:string [Term] id: UBERON:0013151 name: choroidal artery def: "One of two arteries (anterior and posterior choroidal artery) that supply blood to the choroid plexus, optic tract, hippocampus, globus pallidus, and other various brain regions." [ncithesaurus:Choroidal_Artery] synonym: "artery of choroid plexus" EXACT [] synonym: "choroid artery" EXACT [] xref: NCIT:C32310 xref: SCTID:244210009 xref: UMLS:C0226164 {source="ncithesaurus:Choroidal_Artery"} is_a: UBERON:0001637 ! artery intersection_of: UBERON:0001637 ! artery intersection_of: RO:0020101 UBERON:0001886 ! vessel supplies blood to choroid plexus relationship: RO:0020101 UBERON:0001886 ! vessel supplies blood to choroid plexus property_value: skos:prefLabel "choroidal artery" xsd:string [Term] id: UBERON:0013156 name: 1st arch mandibular endoderm synonym: "endoderm of mandibular component" EXACT [EMAPA:16384] xref: EHDAA2:0000033 xref: EMAPA:16384 is_a: UBERON:0003258 ! endoderm of foregut is_a: UBERON:0005291 ! embryonic tissue relationship: BFO:0000050 UBERON:0007237 {source="EHDAA2"} ! part of 1st arch mandibular component relationship: BFO:0000050 UBERON:0009722 {source="EHDAA2"} ! part of entire pharyngeal arch endoderm relationship: RO:0002202 UBERON:0007122 {source="EHDAA2"} ! develops from pharyngeal pouch 1 property_value: skos:prefLabel "1st arch mandibular endoderm" xsd:string [Term] id: UBERON:0013158 name: foregut-midgut junction gland def: "A gland that is part of a foregut-midgut junction." [OBOL:automatic] synonym: "gland of foregut-midgut junction" EXACT [EMAPA:17065] xref: EHDAA2:0000574 xref: EMAPA:17065 is_a: UBERON:0003408 ! gland of digestive tract intersection_of: UBERON:0002530 ! gland intersection_of: BFO:0000050 UBERON:0006235 ! part of foregut-midgut junction relationship: BFO:0000050 UBERON:0006235 ! part of foregut-midgut junction property_value: skos:prefLabel "foregut-midgut junction gland" xsd:string [Term] id: UBERON:0013159 name: epithalamus mantle layer synonym: "mantle layer epithalamus" EXACT [VHOG:0000913] synonym: "mantle layer of epithalamus" EXACT [] xref: EHDAA2:0000449 xref: EHDAA:5435 xref: EMAPA:17533 xref: VHOG:0000913 is_a: UBERON:0004061 ! neural tube mantle layer intersection_of: UBERON:0004061 ! neural tube mantle layer intersection_of: BFO:0000050 UBERON:0001899 ! part of epithalamus relationship: BFO:0000050 UBERON:0001899 ! part of epithalamus relationship: RO:0002202 UBERON:0009580 ! develops from diencephalon mantle layer property_value: skos:prefLabel "epithalamus mantle layer" xsd:string [Term] id: UBERON:0013160 name: epithalamus ventricular layer synonym: "ventricular layer epithalamus" EXACT [VHOG:0000884] synonym: "ventricular layer of epithalamus" EXACT [] xref: EHDAA2:0000450 xref: EHDAA:5437 xref: EMAPA:17535 xref: VHOG:0000884 is_a: UBERON:0004060 ! neural tube ventricular layer intersection_of: UBERON:0004060 ! neural tube ventricular layer intersection_of: BFO:0000050 UBERON:0001899 ! part of epithalamus relationship: BFO:0000050 UBERON:0001899 ! part of epithalamus property_value: skos:prefLabel "epithalamus ventricular layer" xsd:string [Term] id: UBERON:0013161 name: left lateral ventricle def: "A telencephalic ventricle that is in_the_left_side_of a telencephalon." [OBOL:automatic] synonym: "left telencephalic ventricle" EXACT [] xref: FMA:78450 xref: SCTID:368593005 is_a: UBERON:0002285 ! telencephalic ventricle is_a: UBERON:0015212 ! lateral structure intersection_of: UBERON:0002285 ! telencephalic ventricle intersection_of: BSPO:0000120 UBERON:0001893 ! telencephalon relationship: BFO:0000050 UBERON:0002812 {source="FMA"} ! part of left cerebral hemisphere relationship: BSPO:0000120 UBERON:0001893 ! telencephalon property_value: skos:prefLabel "left lateral ventricle" xsd:string [Term] id: UBERON:0013162 name: right lateral ventricle def: "A telencephalic ventricle that is in_the_right_side_of a telencephalon." [OBOL:automatic] synonym: "right telencephalic ventricle" EXACT [] xref: FMA:78449 xref: SCTID:368571000 is_a: UBERON:0002285 ! telencephalic ventricle is_a: UBERON:0015212 ! lateral structure intersection_of: UBERON:0002285 ! telencephalic ventricle intersection_of: BSPO:0000121 UBERON:0001893 ! telencephalon relationship: BFO:0000050 UBERON:0002813 {source="FMA"} ! part of right cerebral hemisphere relationship: BSPO:0000121 UBERON:0001893 ! telencephalon property_value: skos:prefLabel "right lateral ventricle" xsd:string [Term] id: UBERON:0013191 name: ovarian cortex def: "The layer of the ovarian stroma lying immediately beneath the tunica albuginea, composed of connective tissue cells and fibers, among which are scattered primary and secondary (antral) follicles in various stages of development; the cortex varies in thickness according to the age of the individual, becoming thinner with advancing years; included in the follicles are the cumulus oophorus, membrana granulosa (and the granulosa cells inside it), corona radiata, zona pellucida, and primary oocyte; the zona pellucida, theca of follicle, antrum and liquor folliculi are also contained in the follicle; also in the cortex is the corpus luteum derived from the follicles." [MGI:anna] subset: human_reference_atlas subset: pheno_slim synonym: "cortex of ovary" EXACT [FMA:18613] synonym: "cortex ovarii (zona parenchymatosa)" EXACT [FMA:18613] xref: EMAPA:37927 {source="MA:th"} xref: FMA:18613 xref: NCIT:C33243 xref: UMLS:C0227878 {source="ncithesaurus:Ovarian_Cortex"} is_a: UBERON:0001851 ! cortex is_a: UBERON:0005156 ! reproductive structure intersection_of: UBERON:0001851 ! cortex intersection_of: BFO:0000050 UBERON:0000992 ! part of ovary relationship: BFO:0000050 UBERON:0006960 ! part of ovary stroma property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0013192 name: ovarian medulla def: "Highly vascular stroma found in the center of the ovary that forms from embryonic mesenchyme and contains blood vessels, lymphatic vessels, and nerves; this stroma forms the tissue of the hilum by which the ovarian ligament is attached, and through which the blood vessels enter; it does not contain any ovarian follicles." [MGI:anna] subset: pheno_slim synonym: "medulla of ovary" EXACT [FMA:18616] synonym: "medulla ovarii (zona vasculosa)" EXACT [FMA:18616] synonym: "zona vasculosa of Waldeyer" RELATED [Wikipedia:Medulla_of_ovary] xref: EMAPA:37928 {source="MA:th"} xref: FMA:18616 xref: NCIT:C33245 xref: UMLS:C0227879 {source="ncithesaurus:Ovarian_Medulla"} xref: Wikipedia:Medulla_of_ovary is_a: UBERON:0000958 ! medulla of organ is_a: UBERON:0005156 ! reproductive structure intersection_of: UBERON:0000958 ! medulla of organ intersection_of: BFO:0000050 UBERON:0000992 ! part of ovary relationship: BFO:0000050 UBERON:0000992 ! part of ovary [Term] id: UBERON:0013212 name: anal sac gland secretion def: "A bodily secretion that is produced by a gland of anal sac." [OBOL:automatic] synonym: "anal gland secretion" RELATED [] synonym: "castoreum" NARROW SENSU [NCBITaxon:29132] synonym: "civet" NARROW SENSU [NCBITaxon:9673] synonym: "hyena butter" RELATED SENSU [Wikipedia:Hyena_butter] synonym: "musk" RELATED [NCBITaxon:30533] synonym: "odorous sac" RELATED [] is_a: UBERON:0000456 ! secretion of exocrine gland intersection_of: UBERON:0000456 ! secretion of exocrine gland intersection_of: RO:0003001 UBERON:0004760 ! produced by gland of anal canal relationship: RO:0003001 UBERON:0004760 ! produced by gland of anal canal property_value: RO:0002175 NCBITaxon:119825 property_value: RO:0002175 NCBITaxon:30533 property_value: RO:0002175 NCBITaxon:9673 property_value: skos:prefLabel "anal sac gland secretion" xsd:string [Term] id: UBERON:0013228 name: sweat gland of eyelid def: "Glands of Moll, also known as ciliary glands, are modified apocrine sweat glands that are found on the margin of the eyelid. They are next to the base of the eyelashes, and anterior to the Meibomian glands within the distal eyelid margin. These glands are relatively large and tubular-shaped. The glands of Moll are named after Dutch oculist Jacob Anton Moll (1832-1914). Glands of Moll empty into the adjacent lashes. Glands of Moll and Zeis secrete lipid that adds to the superficial layer of the tear film, retarding evaporation. The glands of Moll are prone to infection and blockage of its duct with sebum and cell debris. Blockage of the gland's duct causes swelling which can manifest itself as a stye." [Wikipedia:Gland_of_Moll] synonym: "ciliary gland" EXACT [FMA:59159] synonym: "ciliary gland of moll" EXACT [FMA:59159] synonym: "ciliary sweat gland of eyelid" EXACT [FMA:59159] synonym: "gland of Moll" EXACT [FMA:59159] synonym: "Moll's gland" EXACT [FMA:59159] xref: FMA:59159 xref: NCIT:C32679 xref: SCTID:280586002 xref: Wikipedia:Gland_of_Moll is_a: UBERON:0000382 ! apocrine sweat gland is_a: UBERON:0003605 ! eye skin gland is_a: UBERON:0013229 ! eyelid gland intersection_of: UBERON:0000382 ! apocrine sweat gland intersection_of: BFO:0000050 UBERON:0001711 ! part of eyelid [Term] id: UBERON:0013229 name: eyelid gland def: "Any gland that is part of an eyelid. This includes sebaceous glands (Zeis gland, tarsal gland) and sweat glands (Moll's gland)." [http://orcid.org/0000-0002-6601-2165] synonym: "gland of eyelid" EXACT [] xref: SCTID:280574000 is_a: UBERON:0004859 ! eye gland is_a: UBERON:0015152 ! gland of ocular region intersection_of: UBERON:0002530 ! gland intersection_of: BFO:0000050 UBERON:0001711 ! part of eyelid relationship: BFO:0000050 UBERON:0001711 ! part of eyelid [Term] id: UBERON:0013231 name: sebaceous gland of eyelid def: "Any of the sebaceous glands that are in the eyelid. Examples: gland of Zeis (services eyelashes), gland of Meibom (tarsal gland - unconnected to eyelids)." [http://orcid.org/0000-0002-6601-2165] is_a: UBERON:0003484 ! eye sebaceous gland is_a: UBERON:0013229 ! eyelid gland intersection_of: UBERON:0001821 ! sebaceous gland intersection_of: BFO:0000050 UBERON:0001711 ! part of eyelid [Term] id: UBERON:0013232 name: serous acinus def: "The secretory unit of a serous gland. The acinar portion is composed of serous secreting cells." [http://orcid.org/0000-0002-6601-2165, http://www.siumed.edu/~dking2/intro/glands.htm] synonym: "acinus of serous gland" EXACT [] xref: FMA:86279 is_a: UBERON:0011858 ! acinus of exocrine gland intersection_of: UBERON:0009842 ! glandular acinus intersection_of: BFO:0000050 UBERON:0000409 ! part of serous gland relationship: BFO:0000050 UBERON:0000409 ! part of serous gland relationship: RO:0002473 CL:0000313 ! composed primarily of serous secreting cell property_value: skos:prefLabel "serous acinus" xsd:string [Term] id: UBERON:0013235 name: ventrum def: "A major organism subdivisionthat is the entire part of an anatomical structure ventral to a horizontal plane and bounded on one side by the same horizontal plane." [BSPO:0000068, UBERONREF:0000006] synonym: "front" BROAD [] synonym: "front of body proper" EXACT [FMA:259204] synonym: "ventral part of organism" EXACT [] synonym: "ventral region" BROAD [] synonym: "ventral region of organism" EXACT [] xref: FMA:259204 is_a: UBERON:0000475 ! organism subdivision relationship: RO:0002162 NCBITaxon:33213 ! in taxon Bilateria property_value: skos:prefLabel "ventrum" xsd:string [Term] id: UBERON:0013238 name: future glans is_a: UBERON:0005423 ! developing anatomical structure union_of: UBERON:0013239 ! future glans penis union_of: UBERON:0013240 ! future glans clitoris relationship: BFO:0000050 UBERON:0011757 ! part of differentiated genital tubercle relationship: RO:0002387 UBERON:0035651 ! has potential to develop into glans [Term] id: UBERON:0013239 name: future glans penis def: "A future glans that is part of a male genital tubercle." [OBOL:automatic] synonym: "glans of male genital tubercle" EXACT [] xref: EMAPA:29252 is_a: UBERON:0013238 ! future glans intersection_of: UBERON:0013238 ! future glans intersection_of: BFO:0000050 UBERON:0006261 ! part of male genital tubercle relationship: BFO:0000050 UBERON:0006261 {source="EMAPA"} ! part of male genital tubercle [Term] id: UBERON:0013240 name: future glans clitoris def: "A future glans that is part of a female genital tubercle." [OBOL:automatic] synonym: "glans of female genital tubercle" EXACT [] xref: EMAPA:19170 is_a: UBERON:0013238 ! future glans intersection_of: UBERON:0013238 ! future glans intersection_of: BFO:0000050 UBERON:0006233 ! part of female genital tubercle relationship: BFO:0000050 UBERON:0006233 {source="EMAPA"} ! part of female genital tubercle [Term] id: UBERON:0013241 name: embryonic urethral groove def: "The precursor of the urethra." [http://orcid.org/0000-0002-6601-2165] synonym: "sulcus urethralis primarius" EXACT OMO:0003011 [Wikipedia:Urethral_groove] synonym: "urethral groove" EXACT [] synonym: "urethral sulcus" EXACT [] xref: SCTID:361531004 xref: Wikipedia:Urethral_groove is_a: BFO:0000002 is_a: UBERON:0002050 ! embryonic structure relationship: RO:0002202 UBERON:0004876 {source="Wikipedia"} ! develops from urogenital fold [Term] id: UBERON:0013247 name: male paramesonephric duct def: "An epithelial tube that develops from a Mullerian duct in a male. Later degenerates." [http://orcid.org/0000-0002-6601-2165] synonym: "degenerating mesonephric portion of male paramesonephric duct" RELATED [EMAPA:29161] xref: EHDAA2:0001052 xref: EMAPA:29161 xref: EMAPA:35661 is_a: UBERON:0003914 ! epithelial tube is_a: UBERON:0005156 ! reproductive structure is_a: UBERON:0012275 ! meso-epithelium intersection_of: UBERON:0003914 ! epithelial tube intersection_of: BFO:0000050 UBERON:0000079 ! part of male reproductive system intersection_of: RO:0002202 UBERON:0003890 ! develops from Mullerian duct relationship: BFO:0000050 UBERON:0000079 {source="EHDAA2"} ! part of male reproductive system relationship: RO:0002202 UBERON:0003890 {source="EHDAA2"} ! develops from Mullerian duct property_value: IAO:0000116 "consider separating the duct from the degenerating portion, as in EMAPA" xsd:string [Term] id: UBERON:0013279 name: diaphysis of fibula def: "A diaphysis that is part of a fibula[Automatically generated definition]." [OBOL:automatic, Wikipedia:Body_of_fibula] synonym: "body of fibula" EXACT [FMA:33738] synonym: "corpus fibulae" EXACT [FMA:TA] synonym: "fibula diaphysis" EXACT [FMA:33738] synonym: "shaft of fibula" EXACT [FMA:33738] xref: EMAPA:37892 {source="MA:th"} xref: FMA:33738 xref: SCTID:302528006 xref: Wikipedia:Body_of_fibula is_a: UBERON:0004769 ! diaphysis intersection_of: UBERON:0004769 ! diaphysis intersection_of: BFO:0000050 UBERON:0001446 ! part of fibula relationship: BFO:0000050 UBERON:0001446 ! part of fibula [Term] id: UBERON:0013280 name: diaphysis of tibia def: "A diaphysis that is part of a tibia." [OBOL:automatic, Wikipedia:Body_of_tibia] synonym: "body of the tibia" RELATED [Wikipedia:Body_of_tibia] synonym: "body of tibia" EXACT [FMA:33125] synonym: "corpus tibiae" EXACT [FMA:TA] synonym: "shaft of tibia" EXACT [FMA:33125] synonym: "shaft of tibia" RELATED [Wikipedia:Body_of_tibia] synonym: "tibial diaphysis" EXACT [FMA:33125] xref: EMAPA:37770 {source="MA:th"} xref: FMA:33125 xref: MA:0003049 xref: SCTID:302525009 xref: Wikipedia:Body_of_tibia is_a: UBERON:0004769 ! diaphysis intersection_of: UBERON:0004769 ! diaphysis intersection_of: BFO:0000050 UBERON:0000979 ! part of tibia relationship: BFO:0000050 UBERON:0000979 ! part of tibia [Term] id: UBERON:0013411 name: cranial cavity def: "Anatomical cavity that is the lumen of the skull and contains the brain." [UBERON:cjm] synonym: "cavitas cranii" EXACT OMO:0003011 [FMA:9644, FMA:TA] synonym: "intracranial cavity" RELATED [Wikipedia:Cranial_cavity] synonym: "intracranial space" RELATED [Wikipedia:Cranial_cavity] xref: EMAPA:37497 {source="MA:th"} xref: FMA:9644 xref: MA:0003061 xref: NCIT:C77638 xref: neuronames:2806 xref: SCTID:264452006 xref: UMLS:C0230041 {source="ncithesaurus:Cranial_Cavity"} xref: Wikipedia:Cranial_cavity is_a: UBERON:0002553 ! anatomical cavity intersection_of: UBERON:0002553 ! anatomical cavity intersection_of: RO:0002572 UBERON:0003129 ! luminal space of skull relationship: RO:0002572 UBERON:0003129 ! luminal space of skull property_value: foaf:depiction "http://upload.wikimedia.org/wikipedia/commons/e/ee/Scheme_body_cavities-en.svg" xsd:anyURI property_value: skos:prefLabel "cranial cavity" xsd:string [Term] id: UBERON:0013478 name: cecal tonsil def: "A thickened round patch of lymphoid tissue located at the ileocecal junction adjacent to the sacculus rotundus." [ISBN:0824754077] synonym: "caecal tonsil" EXACT [] synonym: "cecal GALT" RELATED [] xref: SCTID:14239003 is_a: UBERON:0001962 ! gut-associated lymphoid tissue intersection_of: UBERON:0001961 ! mucosa-associated lymphoid tissue intersection_of: BFO:0000050 UBERON:0001153 ! part of caecum relationship: BFO:0000050 UBERON:0000314 ! part of cecum mucosa relationship: RO:0002162 NCBITaxon:8782 ! in taxon Aves [Term] id: UBERON:0013479 name: lung endothelium def: "A blood vessel endothelium that is part of a lung [Automatically generated definition]." [OBOL:automatic] synonym: "respiratory endothelium" RELATED [BTO:0004128] xref: BTO:0004128 xref: CALOHA:TS-0573 is_a: UBERON:0000115 ! lung epithelium is_a: UBERON:0004702 ! respiratory system blood vessel endothelium intersection_of: UBERON:0004638 ! blood vessel endothelium intersection_of: BFO:0000050 UBERON:0002048 ! part of lung property_value: skos:prefLabel "lung endothelium" xsd:string [Term] id: UBERON:0013481 name: crypt of Lieberkuhn of ileum def: "An intestinal crypt that is located in the ileum." [http://orcid.org/0000-0002-6601-2165] subset: pheno_slim synonym: "ileal crypt" EXACT [] synonym: "ileal crypt of Lieberkuhn" EXACT [] synonym: "ileal intestinal crypt" EXACT [] xref: EMAPA:37839 {source="MA:th"} xref: FMA:269061 is_a: UBERON:0001241 ! crypt of Lieberkuhn of small intestine intersection_of: UBERON:0001983 ! crypt of Lieberkuhn intersection_of: BFO:0000050 UBERON:0002116 ! part of ileum relationship: BFO:0000050 UBERON:0008344 {source="FMA"} ! part of intestinal villus of ileum [Term] id: UBERON:0013482 name: crypt of Lieberkuhn of duodenum def: "An intestinal crypt that is located in the duodenum." [http://orcid.org/0000-0002-6601-2165] subset: pheno_slim synonym: "duodenal crypt" EXACT [] synonym: "duodenal crypt of Lieberkuhn" EXACT [] xref: EMAPA:37838 {source="MA:th"} xref: FMA:269063 is_a: UBERON:0001241 ! crypt of Lieberkuhn of small intestine intersection_of: UBERON:0001983 ! crypt of Lieberkuhn intersection_of: BFO:0000050 UBERON:0002114 ! part of duodenum relationship: BFO:0000050 UBERON:0008342 {source="FMA"} ! part of intestinal villus of duodenum [Term] id: UBERON:0013483 name: crypt of Lieberkuhn of jejunum def: "An intestinal crypt that is located in the jejunum." [http://orcid.org/0000-0002-6601-2165] subset: pheno_slim synonym: "jejunal crypt" EXACT [] synonym: "jejunal crypt of Lieberkuhn" EXACT [] xref: EMAPA:37840 {source="MA:th"} xref: FMA:269065 is_a: UBERON:0001241 ! crypt of Lieberkuhn of small intestine intersection_of: UBERON:0001983 ! crypt of Lieberkuhn intersection_of: BFO:0000050 UBERON:0002115 ! part of jejunum relationship: BFO:0000050 UBERON:0008343 {source="FMA"} ! part of intestinal villus of jejunum [Term] id: UBERON:0013485 name: crypt of Lieberkuhn of colon def: "An intestinal crypt that is located in the colon. The colonic crypts of Lieberkühn are straight and unbranched and lined largely with goblet cells." [http://orcid.org/0000-0002-6601-2165] subset: human_reference_atlas synonym: "colonic crypt" EXACT [] synonym: "colonic crypt of Lieberkuhn" EXACT [] xref: SCTID:19447003 is_a: UBERON:0001984 ! crypt of Lieberkuhn of large intestine intersection_of: UBERON:0001983 ! crypt of Lieberkuhn intersection_of: BFO:0000050 UBERON:0001155 ! part of colon relationship: BFO:0000050 UBERON:0000317 ! part of colonic mucosa property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0013486 name: crypt of Lieberkuhn of appendix def: "An intestinal crypt that is located in the appendix." [http://orcid.org/0000-0002-6601-2165] synonym: "appendiceal crypt" EXACT [] synonym: "appendiceal crypt of Lieberkuhn" EXACT [] xref: SCTID:21512007 is_a: UBERON:0001984 ! crypt of Lieberkuhn of large intestine intersection_of: UBERON:0001983 ! crypt of Lieberkuhn intersection_of: BFO:0000050 UBERON:0001154 ! part of vermiform appendix relationship: BFO:0000050 UBERON:0004989 ! part of mucosa of appendix [Term] id: UBERON:0013498 name: vestibulo-cochlear VIII ganglion complex synonym: "vestibular VIII ganglion complex" RELATED [EHDAA2:0004313] synonym: "vestibulocochlear ganglion complex" EXACT [] synonym: "vestibulocochlear VIII ganglion complex" EXACT [] xref: EHDAA2:0004313 xref: EMAPA:17570 is_a: UBERON:0001714 ! cranial ganglion intersection_of: UBERON:0001714 ! cranial ganglion intersection_of: extends_fibers_into UBERON:0001648 ! vestibulocochlear nerve relationship: extends_fibers_into UBERON:0001648 ! vestibulocochlear nerve property_value: IAO:0000116 "requires verification" xsd:string property_value: skos:prefLabel "vestibulo-cochlear VIII ganglion complex" xsd:string [Term] id: UBERON:0013501 name: cloacal sphincter def: "A sphincter muscle that is part of a cloaca." [OBOL:automatic] comment: the muscles of the cloacal sphincter specialise into the perineal muscles in mammals (Gegenbaur, 1883; Popowsky, 1899; Nishi, 1938). synonym: "sphincter cloacae" EXACT OMO:0003004 [] xref: NCIT:C34129 xref: UMLS:C1516658 {source="ncithesaurus:Cloacal_Sphincter"} is_a: UBERON:0004590 ! sphincter muscle is_a: UBERON:0014783 ! cloacal muscle intersection_of: UBERON:0004590 ! sphincter muscle intersection_of: BFO:0000050 UBERON:0000162 ! part of cloaca property_value: skos:prefLabel "cloacal sphincter" xsd:string [Term] id: UBERON:0013502 name: 5th arch mesenchyme def: "A mesenchyme that is part of a pharyngeal arch 5." [OBOL:automatic] synonym: "5th branchial arch mesenchyme" RELATED [] synonym: "5th pharyngeal arch mesenchyme" EXACT [VHOG:0001052] synonym: "pharyngeal arch 5 mesenchyme" RELATED [] is_a: UBERON:0009494 ! pharyngeal arch mesenchymal region intersection_of: UBERON:0003104 ! mesenchyme intersection_of: BFO:0000050 UBERON:0003116 ! part of pharyngeal arch 5 relationship: BFO:0000050 UBERON:0003116 ! part of pharyngeal arch 5 [Term] id: UBERON:0013503 name: caudal vertebra cartilage element def: "A caudal vertebra endochondral element that is composed primarily of cartilage tissue." [OBOL:automatic] synonym: "coccygeal vertebra cartilage element" EXACT [http://orcid.org/0000-0002-6601-2165] synonym: "coccygeal vertebral cartilage condensation group" EXACT [EHDAA2:0000260] synonym: "tail vertebral cartilage condensation" EXACT [EMAPA:18044] xref: EHDAA2:0000260 xref: EMAPA:18044 is_a: UBERON:0011094 ! vertebra cartilage element is_a: UBERON:0018142 ! caudal vertebra endochondral element is_a: UBERON:2001457 ! postcranial axial cartilage intersection_of: UBERON:0018142 ! caudal vertebra endochondral element intersection_of: RO:0002473 UBERON:0002418 ! composed primarily of cartilage tissue relationship: RO:0002202 UBERON:0013504 ! develops from caudal vertebra pre-cartilage condensation relationship: RO:0002387 UBERON:0001095 ! has potential to develop into caudal vertebra property_value: skos:prefLabel "caudal vertebra cartilage element" xsd:string [Term] id: UBERON:0013504 name: caudal vertebra pre-cartilage condensation def: "A caudal vertebra endochondral element that is composed primarily of a pre-cartilage condensation." [OBOL:automatic] synonym: "coccygeal vertebra pre-cartilage condensation" EXACT [http://orcid.org/0000-0002-6601-2165] synonym: "tail vertebral pre-cartilage condensation" EXACT [EMAPA:18045] xref: EMAPA:18045 is_a: UBERON:0011095 ! vertebra pre-cartilage condensation is_a: UBERON:0018142 ! caudal vertebra endochondral element intersection_of: UBERON:0018142 ! caudal vertebra endochondral element intersection_of: RO:0002473 UBERON:0005866 ! composed primarily of pre-cartilage condensation property_value: skos:prefLabel "caudal vertebra pre-cartilage condensation" xsd:string [Term] id: UBERON:0013505 name: cervical vertebra cartilage element def: "A cervical vertebra endochondral element that is composed primarily of cartilage tissue." [OBOL:automatic] synonym: "cervical vertebral cartilage condensation group" EXACT [EHDAA2:0000240] xref: EHDAA2:0000240 is_a: UBERON:0003601 ! neck cartilage is_a: UBERON:0011094 ! vertebra cartilage element is_a: UBERON:0015007 ! cervical vertebra endochondral element is_a: UBERON:2001457 ! postcranial axial cartilage intersection_of: UBERON:0015007 ! cervical vertebra endochondral element intersection_of: RO:0002473 UBERON:0002418 ! composed primarily of cartilage tissue relationship: RO:0002202 UBERON:0013506 ! develops from cervical vertebra pre-cartilage condensation relationship: RO:0002387 UBERON:0002413 ! has potential to develop into cervical vertebra property_value: skos:prefLabel "cervical vertebra cartilage element" xsd:string [Term] id: UBERON:0013506 name: cervical vertebra pre-cartilage condensation def: "A cervical vertebra endochondral element that is composed primarily of a pre-cartilage condensation." [OBOL:automatic] is_a: UBERON:0011095 ! vertebra pre-cartilage condensation is_a: UBERON:0015007 ! cervical vertebra endochondral element intersection_of: UBERON:0015007 ! cervical vertebra endochondral element intersection_of: RO:0002473 UBERON:0005866 ! composed primarily of pre-cartilage condensation property_value: skos:prefLabel "cervical vertebra pre-cartilage condensation" xsd:string [Term] id: UBERON:0013507 name: thoracic vertebra cartilage element def: "A thoracic vertebra endochondral element that is composed primarily of cartilage tissue." [OBOL:automatic] synonym: "thoracic vertebral cartilage condensation group" EXACT [EHDAA2:0002014] xref: EHDAA2:0002014 is_a: UBERON:0011094 ! vertebra cartilage element is_a: UBERON:0015008 ! thoracic vertebra endochondral element is_a: UBERON:2001457 ! postcranial axial cartilage intersection_of: UBERON:0015008 ! thoracic vertebra endochondral element intersection_of: RO:0002473 UBERON:0002418 ! composed primarily of cartilage tissue relationship: RO:0002202 UBERON:0013508 ! develops from thoracic vertebra pre-cartilage condensation relationship: RO:0002387 UBERON:0002347 ! has potential to develop into thoracic vertebra property_value: skos:prefLabel "thoracic vertebra cartilage element" xsd:string [Term] id: UBERON:0013508 name: thoracic vertebra pre-cartilage condensation def: "A thoracic vertebra endochondral element that is composed primarily of a pre-cartilage condensation." [OBOL:automatic] is_a: UBERON:0011095 ! vertebra pre-cartilage condensation is_a: UBERON:0015008 ! thoracic vertebra endochondral element intersection_of: UBERON:0015008 ! thoracic vertebra endochondral element intersection_of: RO:0002473 UBERON:0005866 ! composed primarily of pre-cartilage condensation property_value: skos:prefLabel "thoracic vertebra pre-cartilage condensation" xsd:string [Term] id: UBERON:0013509 name: lumbar vertebra cartilage element def: "A lumbar vertebra endochondral element that is composed primarily of cartilage tissue." [OBOL:automatic] synonym: "lumbar vertebral cartilage condensation group" EXACT [EHDAA2:0001038] xref: EHDAA2:0001038 is_a: UBERON:0011094 ! vertebra cartilage element is_a: UBERON:0015009 ! lumbar vertebra endochondral element is_a: UBERON:2001457 ! postcranial axial cartilage intersection_of: UBERON:0015009 ! lumbar vertebra endochondral element intersection_of: RO:0002473 UBERON:0002418 ! composed primarily of cartilage tissue relationship: RO:0002202 UBERON:0013510 ! develops from lumbar vertebra pre-cartilage condensation relationship: RO:0002387 UBERON:0002414 ! has potential to develop into lumbar vertebra [Term] id: UBERON:0013510 name: lumbar vertebra pre-cartilage condensation def: "A lumbar vertebra endochondral element that is composed primarily of a pre-cartilage condensation." [OBOL:automatic] is_a: UBERON:0011095 ! vertebra pre-cartilage condensation is_a: UBERON:0015009 ! lumbar vertebra endochondral element intersection_of: UBERON:0015009 ! lumbar vertebra endochondral element intersection_of: RO:0002473 UBERON:0005866 ! composed primarily of pre-cartilage condensation [Term] id: UBERON:0013514 name: space surrounding organism def: "The space that surrounds an organism." [https://orcid.org/0000-0002-6601-2165] synonym: "external to organism" EXACT [] synonym: "outside of body" EXACT [] is_a: UBERON:0000464 ! anatomical space intersection_of: UBERON:0000464 ! anatomical space intersection_of: RO:0002221 UBERON:0000468 ! surrounds multicellular organism relationship: RO:0002221 UBERON:0000468 ! surrounds multicellular organism property_value: skos:prefLabel "space surrounding organism" xsd:string [Term] id: UBERON:0013515 name: subdivision of oviduct def: "A section through the tube or network of tubes that connects the ovaries to the outside of the body." [http://orcid.org/0000-0002-6601-2165] subset: non_informative synonym: "subdivision of fallopian tube" NARROW [FMA:18302] synonym: "subdivision of oviduct" EXACT [FMA:18302] synonym: "subdivision of uterine tube" EXACT [] synonym: "uterine tube zone" EXACT [FMA:18302] synonym: "zone of uterine tube" EXACT [FMA:18302] xref: FMA:18302 is_a: UBERON:0005156 ! reproductive structure is_a: UBERON:0013522 ! subdivision of tube intersection_of: UBERON:0013522 ! subdivision of tube intersection_of: subdivision_of UBERON:0000993 ! oviduct relationship: BFO:0000050 UBERON:0000993 ! part of oviduct relationship: subdivision_of UBERON:0000993 ! oviduct [Term] id: UBERON:0013522 name: subdivision of tube is_a: UBERON:0000064 ! organ part relationship: BFO:0000050 UBERON:0000025 ! part of tube relationship: BFO:0000051 UBERON:0000060 ! has part anatomical wall relationship: BFO:0000051 UBERON:0000464 ! has part anatomical space relationship: subdivision_of UBERON:0000025 ! tube property_value: skos:prefLabel "subdivision of tube" xsd:string [Term] id: UBERON:0013525 name: stomach lumen def: "The anatomical space that is enclosed by a stomach." [http://orcid.org/0000-0002-6601-2165] synonym: "cavity of stomach" EXACT [FMA:14585] synonym: "gastric cavity" RELATED [FMA:14585] xref: EMAPA:18395 xref: FMA:14585 is_a: UBERON:0000464 ! anatomical space intersection_of: UBERON:0000464 ! anatomical space intersection_of: RO:0002572 UBERON:0000945 ! luminal space of stomach relationship: BFO:0000050 UBERON:0011565 {source="FMA"} ! part of lumen of gastrointestinal system relationship: RO:0002572 UBERON:0000945 ! luminal space of stomach property_value: skos:prefLabel "stomach lumen" xsd:string [Term] id: UBERON:0013526 name: otocyst lumen def: "An anatomical cavity that is part of a ear vesicle." [OBOL:automatic] synonym: "lumen of otocyst" EXACT [EMAPA:25363] xref: EHDAA2:0004121 xref: EMAPA:25363 is_a: BFO:0000002 is_a: UBERON:0002553 ! anatomical cavity is_a: UBERON:0007473 {source="EHDAA2"} ! lumen of epithelial sac intersection_of: UBERON:0002553 ! anatomical cavity intersection_of: RO:0002572 UBERON:0003051 ! luminal space of ear vesicle relationship: RO:0002202 UBERON:0006273 {source="EHDAA2"} ! develops from otic pit relationship: RO:0002572 UBERON:0003051 ! luminal space of ear vesicle property_value: skos:prefLabel "otocyst lumen" xsd:string [Term] id: UBERON:0013605 name: layer of lateral geniculate body is_a: UBERON:0011215 ! central nervous system cell part cluster is_a: UBERON:0022303 ! nervous system cell part layer intersection_of: UBERON:0022303 ! nervous system cell part layer intersection_of: BFO:0000050 UBERON:0001926 ! part of lateral geniculate body relationship: BFO:0000050 UBERON:0001926 ! part of lateral geniculate body property_value: skos:prefLabel "layer of lateral geniculate body" xsd:string [Term] id: UBERON:0013606 name: magnocellular layer of dorsal nucleus of lateral geniculate body comment: Rods; necessary for the perception of movement, depth, and small differences in brightness[WP] synonym: "lateral geniculate nucleus magnocellular layer" EXACT [] synonym: "magnocellular layer of lateral geniculate nucleus" EXACT [] synonym: "strata magnocellularia" BROAD [] synonym: "strata magnocellularia nuclei dorsalis corporis geniculati lateralis" EXACT OMO:0003011 [FMA:76989, FMA:TA] xref: DHBA:10431 xref: FMA:76989 xref: PBA:128013078 is_a: BFO:0000002 is_a: UBERON:0013605 ! layer of lateral geniculate body intersection_of: UBERON:0013605 ! layer of lateral geniculate body intersection_of: RO:0002473 CL:0011003 ! composed primarily of magnocellular neurosecretory cell relationship: BFO:0000050 UBERON:0002479 ! part of dorsal lateral geniculate nucleus relationship: RO:0002473 CL:0011003 ! composed primarily of magnocellular neurosecretory cell property_value: skos:prefLabel "magnocellular layer of dorsal nucleus of lateral geniculate body" xsd:string [Term] id: UBERON:0013607 name: parvocellular layer of dorsal nucleus of lateral geniculate body comment: Cones; long- and medium-wavelength ("red" and "green" cones); necessary for the perception of color and form (fine details).[WP] synonym: "parvocellular layer of lateral geniculate nucleus" EXACT [] synonym: "strata parvocellularia" BROAD [] synonym: "strata parvocellularia nuclei dorsalis corporis geniculati lateralis" EXACT OMO:0003011 [FMA:76992, FMA:TA] xref: FMA:76992 xref: PBA:128013091 is_a: BFO:0000002 is_a: UBERON:0013605 ! layer of lateral geniculate body intersection_of: UBERON:0013605 ! layer of lateral geniculate body intersection_of: RO:0002473 CL:1001505 ! composed primarily of parvocellular neurosecretory cell relationship: BFO:0000050 UBERON:0002479 ! part of dorsal lateral geniculate nucleus relationship: RO:0002473 CL:1001505 ! composed primarily of parvocellular neurosecretory cell [Term] id: UBERON:0013615 name: koniocellular layer of dorsal nucleus of lateral geniculate body comment: Short-wavelength "blue" cones.[WP] synonym: "konioocellular layer of lateral geniculate nucleus" EXACT [] synonym: "stratum koniocellulare nuclei dorsalis corporis geniculati lateralis" EXACT OMO:0003011 [FMA:76988, FMA:TA] xref: FMA:76988 is_a: UBERON:0013605 ! layer of lateral geniculate body relationship: BFO:0000050 UBERON:0002479 ! part of dorsal lateral geniculate nucleus [Term] id: UBERON:0013630 name: short bone def: "Short bones are designated as those bones that are as wide as they are long. Their primary function is to provide support and stability with little to no movement. They are one of five types of bones: long, short, flat, irregular and sesamoid. Examples of these bones include the tarsals in the foot and the carpals in the hand." [Wikipedia:Short_bone] xref: FMA:7475 xref: NCIT:C33545 xref: SCTID:332807009 xref: Wikipedia:Short_bone is_a: UBERON:0001474 {source="NCIT"} ! bone element property_value: IAO:0000116 "TODO - make subclass links" xsd:string [Term] id: UBERON:0013631 name: sesamoid element def: "Ossicle that develops within bands of dense, regular connective tissue (e.g., tendons and ligaments). Sesamoids are generally located proximate to a bony prominence, over which the dense regular connective tissue wraps, and/or a joint or articulation." [PSPUB:0000169, VSAO:0000137] comment: Sesamoids are often endochondral replacement elements and in addition to bone tissue, may also be composed of articular cartilage, fibrocartilage, hyaline cartilage, and calcified cartilage. synonym: "sesamoid" EXACT [VSAO:0000137] xref: VSAO:0000137 is_a: BFO:0000002 is_a: UBERON:0010911 {source="VSAO"} ! ossicle relationship: RO:0002162 NCBITaxon:7742 ! in taxon Vertebrata relationship: RO:0002226 UBERON:0007846 {source="VSAO"} ! develops in dense regular connective tissue [Term] id: UBERON:0013632 name: sesamoid cartilage def: "A sesamoid element that is composed primarily of cartilage tissue." [OBOL:automatic] synonym: "cartilago sesamoidea" EXACT [FMA:55379] synonym: "sesamoid cartilage of cricopharyngeal ligament" EXACT [FMA:55379] xref: FMA:55379 is_a: UBERON:0007844 ! cartilage element is_a: UBERON:0013631 ! sesamoid element intersection_of: UBERON:0013631 ! sesamoid element intersection_of: RO:0002473 UBERON:0002418 ! composed primarily of cartilage tissue [Term] id: UBERON:0013636 name: epithelium of intestinal villus def: "An epithelium that is part of a intestinal villus." [OBOL:automatic] synonym: "intestinal villus epithelium" EXACT [FMA:63587] synonym: "villous epithelium" RELATED [] synonym: "villus epithelium" RELATED [] xref: FMA:63587 is_a: UBERON:0001902 ! epithelium of small intestine intersection_of: UBERON:0000483 ! epithelium intersection_of: BFO:0000050 UBERON:0001213 ! part of intestinal villus relationship: BFO:0000050 UBERON:0001213 ! part of intestinal villus relationship: BFO:0000050 UBERON:0001902 {source="FMA"} ! part of epithelium of small intestine property_value: skos:prefLabel "epithelium of intestinal villus" xsd:string [Term] id: UBERON:0013637 name: prostate gland lateral lobe def: "The prostate gland lobe that is located on the lateral side of the organ." [ncithesaurus:Lateral_Lobe_of_the_Prostate] synonym: "lateral lobe of prostate" EXACT [FMA:19577] synonym: "lateral lobe of prostate gland" EXACT [FMA:19577] synonym: "lateral prostate" RELATED [] synonym: "lateral ventral lobe of prostate gland" RELATED [MorphoBank:MorphoBank] xref: EMAPA:29822 xref: FMA:19577 xref: MA:0003125 xref: NCIT:C13092 is_a: UBERON:0001328 ! lobe of prostate is_a: UBERON:0015212 ! lateral structure intersection_of: UBERON:0001328 ! lobe of prostate intersection_of: BSPO:0000126 UBERON:0002367 ! prostate gland relationship: BSPO:0000126 UBERON:0002367 ! prostate gland [Term] id: UBERON:0013683 name: left dorsal thalamus def: "A dorsal thalamus that is in_the_left_side_of a diencephalon." [OBOL:automatic] subset: pheno_slim synonym: "left thalamus" BROAD [FMA:258716] xref: FMA:258716 is_a: UBERON:0004703 ! dorsal thalamus is_a: UBERON:0015212 ! lateral structure intersection_of: UBERON:0004703 ! dorsal thalamus intersection_of: BSPO:0000120 UBERON:0001894 ! diencephalon relationship: BSPO:0000120 UBERON:0001894 ! diencephalon property_value: skos:prefLabel "left dorsal thalamus" xsd:string [Term] id: UBERON:0013684 name: right dorsal thalamus def: "A dorsal thalamus that is in_the_right_side_of a diencephalon." [OBOL:automatic] subset: pheno_slim synonym: "right thalamus" BROAD [FMA:258714] xref: FMA:258714 is_a: UBERON:0004703 ! dorsal thalamus is_a: UBERON:0015212 ! lateral structure intersection_of: UBERON:0004703 ! dorsal thalamus intersection_of: BSPO:0000121 UBERON:0001894 ! diencephalon relationship: BSPO:0000121 UBERON:0001894 ! diencephalon property_value: skos:prefLabel "right dorsal thalamus" xsd:string [Term] id: UBERON:0013685 name: foramen of skull def: "Anatomical space that is an opening in a bone of the skull." [http://orcid.org/0000-0002-6601-2165, TAO:curator] synonym: "cranial conduit" NARROW [FMA:53165] synonym: "cranial foramen" NARROW [] synonym: "foramen of skull" EXACT [Wikipedia:Foramina_of_the_skull] synonym: "foramina of the skull" RELATED OMO:0003004 [Wikipedia:Foramina_of_the_skull] xref: FMA:53165 xref: SCTID:276742007 xref: Wikipedia:Foramina_of_the_skull is_a: UBERON:0005744 ! bone foramen intersection_of: UBERON:0005744 ! bone foramen intersection_of: BFO:0000050 UBERON:0003129 ! part of skull relationship: BFO:0000050 UBERON:0003129 ! part of skull property_value: skos:prefLabel "foramen of skull" xsd:string [Term] id: UBERON:0013686 name: anatomical conduit space def: "An anatomical space which is the lumen of some anatomical conduit and connects two or more spaces together[FMA,modified]." [FMA:9338, http://orcid.org/0000-0002-6601-2165] subset: common_anatomy synonym: "foramen space" NARROW [] xref: FMA:9338 is_a: UBERON:0000464 {source="FMA"} ! anatomical space relationship: RO:0002176 UBERON:0000464 ! connects anatomical space relationship: RO:0002176 UBERON:0000464 {cardinality="2"} ! connects anatomical space relationship: RO:0002572 UBERON:0004111 ! luminal space of anatomical conduit property_value: RO:0002175 NCBITaxon:33090 property_value: RO:0002175 NCBITaxon:33208 property_value: RO:0002175 NCBITaxon:4751 property_value: skos:prefLabel "anatomical conduit space" xsd:string [Term] id: UBERON:0013687 name: pericranium def: "Periosteum that is part of a skull." [OBOL:automatic] synonym: "periosteum externum cranii" EXACT OMO:0003011 [FMA:76623, FMA:TA] xref: FMA:76623 is_a: UBERON:0002515 ! periosteum intersection_of: UBERON:0002515 ! periosteum intersection_of: BFO:0000050 UBERON:0003129 ! part of skull relationship: BFO:0000050 UBERON:0003129 ! part of skull [Term] id: UBERON:0013688 name: tonsil germinal center def: "A germinal center that is part of a tonsil." [OBOL:automatic] subset: human_reference_atlas synonym: "tonsil reaction center" RELATED [CALOHA:TS-1288] xref: CALOHA:TS-1288 is_a: UBERON:0010754 ! germinal center intersection_of: UBERON:0010754 ! germinal center intersection_of: BFO:0000050 UBERON:0002372 ! part of tonsil relationship: BFO:0000050 UBERON:0002372 ! part of tonsil property_value: IAO:0000116 "consider adding related terms, e.g. secondary lymphoid tissue of tonsil" xsd:string property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0013689 name: appendix lymphoid tissue def: "Lymphoid tissue located in the appendix." [CALOHA:TS-1268] synonym: "appendix lymphoid" RELATED [CALOHA:TS-1268] synonym: "lymphatic tissue of appendix" EXACT [OBOL:automatic] synonym: "lymphatic tissue of vermiform appendix" EXACT [OBOL:automatic] xref: CALOHA:TS-1268 is_a: UBERON:0001744 ! lymphoid tissue intersection_of: UBERON:0001744 ! lymphoid tissue intersection_of: BFO:0000050 UBERON:0001154 ! part of vermiform appendix relationship: BFO:0000050 UBERON:0001154 ! part of vermiform appendix [Term] id: UBERON:0013694 name: brain endothelium def: "Vascular endothelium found in blood vessels of the blood-brain-barrier." [CALOHA:TS-0092] synonym: "cerebromicrovascular endothelium" RELATED [CALOHA:TS-0092] xref: BTO:0001852 xref: BTO:0003248 xref: CALOHA:TS-0092 is_a: UBERON:0001986 ! endothelium intersection_of: UBERON:0001986 ! endothelium intersection_of: BFO:0000050 UBERON:0000955 ! part of brain relationship: BFO:0000050 UBERON:0000955 ! part of brain property_value: skos:prefLabel "brain endothelium" xsd:string [Term] id: UBERON:0013695 name: colon endothelium def: "Vascular endothelium found in colon blood vessels." [CALOHA:TS-0162] synonym: "colon endothelial cell" RELATED [CALOHA:TS-0162] synonym: "colon endothelial cells" RELATED [CALOHA:TS-0162] synonym: "colonic endothelial cell" RELATED [CALOHA:TS-0162] synonym: "colonic endothelium" RELATED [CALOHA:TS-0162] synonym: "colorectal endothelial cell" RELATED [CALOHA:TS-0162] synonym: "colorectal endothelium" RELATED [CALOHA:TS-0162] xref: CALOHA:TS-0162 is_a: UBERON:0000397 ! colonic epithelium is_a: UBERON:0001986 ! endothelium intersection_of: UBERON:0001986 ! endothelium intersection_of: BFO:0000050 UBERON:0001155 ! part of colon property_value: skos:prefLabel "colon endothelium" xsd:string [Term] id: UBERON:0013696 name: tonsil epithelium def: "The epithelium that forms the surface of the tonsil dips into the underlying connective tissue in numerous places, forming crypts kown as tonsillar crypts. Stratified squamous epithelium, that may be heavily infiltrated by lymphocytes. Epithelial cells are present in the germinal as well as in the periphery of the nodule." [CALOHA:TS-2070] subset: human_reference_atlas synonym: "epithelium of tonsil" RELATED [CALOHA:TS-2070] synonym: "tonsil epithelial cell" RELATED [CALOHA:TS-2070] xref: CALOHA:TS-2070 is_a: UBERON:0003351 ! pharyngeal epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: BFO:0000050 UBERON:0002372 ! part of tonsil relationship: BFO:0000050 UBERON:0002372 ! part of tonsil property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0013697 name: exocrine pancreas epithelium def: "Epithelium lining the exocrine pancreas." [CALOHA:TS-2108] synonym: "epithelium of exocrine pancreas" RELATED [CALOHA:TS-2108] synonym: "exocrine pancreas epithelial cell" RELATED [CALOHA:TS-2108] xref: CALOHA:TS-2108 is_a: UBERON:0000483 ! epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: BFO:0000050 UBERON:0000017 ! part of exocrine pancreas relationship: BFO:0000050 UBERON:0000017 ! part of exocrine pancreas property_value: skos:prefLabel "exocrine pancreas epithelium" xsd:string [Term] id: UBERON:0013699 name: strand of axillary hair def: "A strand of hair that is part of a axilla." [OBOL:automatic] subset: pheno_slim synonym: "axilla hair" EXACT [] synonym: "axillary hair" EXACT [FMA:54253] synonym: "hair of axilla" EXACT [FMA:54253] xref: FMA:54253 xref: SCTID:280911007 is_a: UBERON:0001037 ! strand of hair intersection_of: UBERON:0001037 ! strand of hair intersection_of: BFO:0000050 UBERON:0009472 ! part of axilla relationship: BFO:0000050 UBERON:0009472 ! part of axilla [Term] id: UBERON:0013700 name: axial musculature def: "Musculature of the head and neck, spine, and ribs." [HP:0003327] xref: EHDAA2:0000159 xref: EMAPA:18166 is_a: UBERON:0001015 ! musculature intersection_of: UBERON:0001015 ! musculature intersection_of: BFO:0000050 UBERON:0013701 ! part of main body axis intersection_of: RO:0002371 UBERON:0005944 ! attached to axial skeleton plus cranial skeleton relationship: BFO:0000050 UBERON:0013701 ! part of main body axis relationship: RO:0002371 UBERON:0005944 ! attached to axial skeleton plus cranial skeleton property_value: skos:prefLabel "axial musculature" xsd:string [Term] id: UBERON:0013701 name: main body axis def: "A principle subdivision of an organism that includes all structures along the primary axis, typically the anterior-posterior axis, from head to tail, including structures of the body proper where present (for example, ribs), but excluding appendages." [https://orcid.org/0000-0002-6601-2165] subset: non_informative is_a: UBERON:0000475 ! organism subdivision relationship: RO:0002162 NCBITaxon:6072 ! in taxon Eumetazoa property_value: skos:prefLabel "main body axis" xsd:string [Term] id: UBERON:0013702 name: body proper def: "The region of the organism associated with the visceral organs." [AEO:0000103] subset: non_informative synonym: "body" RELATED [AEO:0000103] synonym: "whole body" RELATED [BTO:0001489] xref: AEO:0000103 xref: BTO:0001489 xref: FMA:231424 is_a: UBERON:0000475 {source="AEO"} ! organism subdivision relationship: BFO:0000050 UBERON:0013701 ! part of main body axis property_value: skos:prefLabel "body proper" xsd:string [Term] id: UBERON:0013703 name: integumentary projection def: "Anatomical projection that is part of the integumentl system." [http://orcid.org/0000-0002-6601-2165] synonym: "skin projection" NARROW [] is_a: UBERON:0004529 ! anatomical projection is_a: UBERON:0006003 ! integumentary adnexa intersection_of: UBERON:0004529 ! anatomical projection intersection_of: BFO:0000050 UBERON:0002416 ! part of integumental system [Term] id: UBERON:0013704 name: notochordal canal def: "A tubular passage that extends from the primitive pit into the head process during the early stages of embryonic development in mammals. It perforates the splanchnopleure layer so that the yolk sac and the amnion are connected temporarily." [http://medical-dictionary.thefreedictionary.com/notochordal+canal] synonym: "chordal canal" RELATED [] xref: FMA:293127 xref: NCIT:C34230 xref: UMLS:C1518428 {source="ncithesaurus:Notochordal_Canal"} is_a: UBERON:0004111 ! anatomical conduit intersection_of: UBERON:0004111 ! anatomical conduit intersection_of: BFO:0000050 UBERON:0006268 ! part of notochordal process relationship: BFO:0000050 UBERON:0006268 ! part of notochordal process property_value: skos:prefLabel "notochordal canal" xsd:string [Term] id: UBERON:0013727 name: notochordal fluid def: "Fluid contained within the notochordal canal." [http://animaldiversity.org/accounts/Latimeria_chalumnae/, http://orcid.org/0000-0002-6601-2165] comment: Distinct feature of coelocanths synonym: "notochord fluid" EXACT [] synonym: "portion of notochordal fluid" EXACT [] is_a: UBERON:0006314 ! bodily fluid intersection_of: UBERON:0006314 ! bodily fluid intersection_of: BFO:0000050 UBERON:0036242 ! part of post-embryonic notochord intersection_of: RO:0001025 UBERON:0013704 ! located in notochordal canal relationship: BFO:0000050 UBERON:0036242 ! part of post-embryonic notochord relationship: RO:0001025 UBERON:0013704 ! located in notochordal canal property_value: skos:prefLabel "notochordal fluid" xsd:string [Term] id: UBERON:0013739 name: base of crypt of Lieberkuhn def: "The basal portion (further from lumen) of an intestinal crypt. Contains multipotent stem cells. Stem cells in the crypts divide to form daughter cells. One daughter cell from each stem cell division is retained as a stem cell. The other becomes committed to differentiate along one of four pathways to become an enterocyte, enteroendocrine cell, goblet cell or Paneth cell." [http://orcid.org/0000-0002-6601-2165, UBERON:md] synonym: "basal portion of intestinal gland" EXACT [] synonym: "base of intestinal gland" EXACT [] synonym: "base part of epithelium of intestinal gland" EXACT [] is_a: UBERON:0011184 ! epithelium of crypt of Lieberkuhn intersection_of: UBERON:0000483 ! epithelium intersection_of: BFO:0000050 UBERON:0001983 ! part of crypt of Lieberkuhn intersection_of: RO:0002150 UBERON:0013740 ! continuous with wall of crypt of Lieberkuhn relationship: RO:0002150 UBERON:0013740 ! continuous with wall of crypt of Lieberkuhn [Term] id: UBERON:0013740 name: wall of crypt of Lieberkuhn def: "The lateral parts of an intestinal crypt, continuous distally with the base and proximally with the intestinal villus epithelium." [http://orcid.org/0000-0002-6601-2165, UBERON:md] synonym: "wall of intestinal gland" EXACT [] synonym: "wall part of epithelium of intestinal gland" EXACT [] is_a: UBERON:0011184 ! epithelium of crypt of Lieberkuhn intersection_of: UBERON:0000483 ! epithelium intersection_of: BFO:0000050 UBERON:0001983 ! part of crypt of Lieberkuhn intersection_of: RO:0002150 UBERON:0013739 ! continuous with base of crypt of Lieberkuhn relationship: RO:0002150 UBERON:0013636 ! continuous with epithelium of intestinal villus relationship: RO:0002150 UBERON:0013739 ! continuous with base of crypt of Lieberkuhn [Term] id: UBERON:0013741 name: base of crypt of Lieberkuhn of large intestine def: "A base of crypt of Lieberkuhn that is part of a large intestine." [OBOL:automatic] is_a: UBERON:0001278 ! epithelium of large intestine is_a: UBERON:0013739 ! base of crypt of Lieberkuhn intersection_of: UBERON:0013739 ! base of crypt of Lieberkuhn intersection_of: BFO:0000050 UBERON:0000059 ! part of large intestine [Term] id: UBERON:0013742 name: wall of crypt of Lieberkuhn of large intestine def: "A wall of crypt of Lieberkuhn that is part of a large intestine." [OBOL:automatic] is_a: UBERON:0001278 ! epithelium of large intestine is_a: UBERON:0013740 ! wall of crypt of Lieberkuhn intersection_of: UBERON:0013740 ! wall of crypt of Lieberkuhn intersection_of: BFO:0000050 UBERON:0000059 ! part of large intestine [Term] id: UBERON:0013743 name: base of crypt of Lieberkuhn of small intestine def: "The basal portion (further from lumen) of a intestinal crypt that is located in the small intestine." [http://orcid.org/0000-0002-6601-2165] is_a: UBERON:0001902 ! epithelium of small intestine is_a: UBERON:0013739 ! base of crypt of Lieberkuhn intersection_of: UBERON:0013739 ! base of crypt of Lieberkuhn intersection_of: BFO:0000050 UBERON:0002108 ! part of small intestine [Term] id: UBERON:0013744 name: wall of crypt of Lieberkuhn of small intestine def: "The lateral parts of an intestinal crypt that is located in the small intestine, continuous distally with the base and proximally with the intestinal villus epithelium." [http://orcid.org/0000-0002-6601-2165] is_a: UBERON:0001902 ! epithelium of small intestine is_a: UBERON:0013740 ! wall of crypt of Lieberkuhn intersection_of: UBERON:0013740 ! wall of crypt of Lieberkuhn intersection_of: BFO:0000050 UBERON:0002108 ! part of small intestine [Term] id: UBERON:0013749 name: metaphysis of humerus def: "A metaphysis that is part of a metaphysis." [OBOL:automatic] subset: pheno_slim synonym: "diaphyseal end of humerus" EXACT [FMA:32830] synonym: "humeral metaphysis" EXACT [FMA:32830] xref: FMA:32830 is_a: UBERON:0001438 ! metaphysis intersection_of: UBERON:0001438 ! metaphysis intersection_of: BFO:0000050 UBERON:0000976 ! part of humerus relationship: BFO:0000050 UBERON:0000976 ! part of humerus [Term] id: UBERON:0013750 name: metaphysis of tibia def: "A metaphysis that is part of a tibia." [OBOL:automatic] subset: pheno_slim synonym: "tibial metaphysis" EXACT [FMA:33135] xref: EMAPA:37772 {source="MA:th"} xref: FMA:33135 xref: MA:0003106 is_a: UBERON:0001438 ! metaphysis intersection_of: UBERON:0001438 ! metaphysis intersection_of: BFO:0000050 UBERON:0000979 ! part of tibia relationship: BFO:0000050 UBERON:0000979 ! part of tibia [Term] id: UBERON:0013752 name: diaphysis of metacarpal bone def: "A diaphysis that is part of a metacarpal bone." [OBOL:automatic] synonym: "body of metacarpal" EXACT [FMA:33804] synonym: "corpus ossis metacarpi" EXACT [FMA:TA] synonym: "metacarpal bone diaphysis" EXACT [FMA:33804] synonym: "shaft of metacarpal" EXACT [FMA:33804] synonym: "shaft of metacarpal bone" EXACT [FMA:33804] xref: FMA:33804 is_a: UBERON:0004769 ! diaphysis intersection_of: UBERON:0004769 ! diaphysis intersection_of: BFO:0000050 UBERON:0002374 ! part of metacarpal bone relationship: BFO:0000050 UBERON:0002374 ! part of metacarpal bone [Term] id: UBERON:0013754 name: integumentary system layer def: "An organ component layer that is part of a integumental system." [OBOL:automatic] subset: non_informative synonym: "layer of skin" NARROW [] synonym: "skin layer" NARROW [] xref: SCTID:314820002 is_a: UBERON:0004923 ! organ component layer intersection_of: UBERON:0004923 ! organ component layer intersection_of: BFO:0000050 UBERON:0002416 ! part of integumental system relationship: BFO:0000050 UBERON:0002416 ! part of integumental system property_value: skos:prefLabel "integumentary system layer" xsd:string [Term] id: UBERON:0013755 name: arterial blood def: "A blood that is part of a artery." [OBOL:automatic] subset: pheno_slim synonym: "arterial blood" EXACT [FMA:83066] synonym: "blood in artery" EXACT [FMA:83066] synonym: "portion of arterial blood" EXACT [FMA:83066] xref: FMA:83066 is_a: UBERON:0000178 ! blood intersection_of: UBERON:0000178 ! blood intersection_of: RO:0001025 UBERON:0001637 ! located in artery relationship: RO:0001025 UBERON:0001637 ! located in artery property_value: skos:prefLabel "arterial blood" xsd:string [Term] id: UBERON:0013756 name: venous blood def: "A blood that is part of a vein." [OBOL:automatic] synonym: "blood in vein" EXACT [FMA:83067] synonym: "portion of venous blood" EXACT [FMA:83067] synonym: "venous blood" EXACT [FMA:83067] xref: FMA:83067 is_a: UBERON:0000178 ! blood intersection_of: UBERON:0000178 ! blood intersection_of: RO:0001025 UBERON:0001638 ! located in vein relationship: RO:0001025 UBERON:0001638 ! located in vein property_value: skos:prefLabel "venous blood" xsd:string [Term] id: UBERON:0013757 name: capillary blood def: "A blood that is part of a capillary." [OBOL:automatic] synonym: "blood in capillary" EXACT [] synonym: "portion of blood in capillary" EXACT [FMA:263901] synonym: "portion of capillary blood" EXACT [] xref: FMA:263901 xref: NCIT:C32212 is_a: UBERON:0000178 ! blood intersection_of: UBERON:0000178 ! blood intersection_of: RO:0001025 UBERON:0001982 ! located in capillary relationship: RO:0001025 UBERON:0001982 ! located in capillary property_value: skos:prefLabel "capillary blood" xsd:string [Term] id: UBERON:0013758 name: cervical os def: "One of two openings in the uterine cervix." [http://orcid.org/0000-0002-6601-2165] synonym: "cervical opening" RELATED [] synonym: "uterine cervix opening" RELATED [] xref: FMA:20422 is_a: UBERON:0000161 ! orifice is_a: UBERON:0005156 ! reproductive structure intersection_of: UBERON:0000161 ! orifice intersection_of: BFO:0000050 UBERON:0000002 ! part of uterine cervix relationship: BFO:0000050 UBERON:0000002 ! part of uterine cervix [Term] id: UBERON:0013760 name: external cervical os def: "Opening of uterine cervix into the vagina." [http://orcid.org/0000-0002-6601-2165] synonym: "external os" RELATED [Wikipedia:External_orifice_of_the_uterus] synonym: "external os of uterus" EXACT [FMA:76836] synonym: "ostium of uterus" RELATED [Wikipedia:External_orifice_of_the_uterus] synonym: "ostium uteri" EXACT [FMA:TA] xref: FMA:76836 xref: NCIT:C32491 xref: SCTID:362255005 xref: UMLS:C1512165 {source="ncithesaurus:Ectocervical_Os"} xref: Wikipedia:External_orifice_of_the_uterus is_a: UBERON:0013758 ! cervical os intersection_of: UBERON:0013758 ! cervical os intersection_of: RO:0002150 UBERON:0000996 ! continuous with vagina relationship: BFO:0000050 UBERON:0012249 ! part of ectocervix relationship: RO:0002150 UBERON:0000996 ! continuous with vagina relationship: RO:0002176 UBERON:0000002 ! connects uterine cervix relationship: RO:0002176 UBERON:0000996 ! connects vagina property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/uterus-female/v1.2/assets/3d-vh-f-uterus.glb" xsd:anyURI [Term] id: UBERON:0013761 name: cervical cavity def: "The cavity formed by the walls of the cervix." [http://orcid.org/0000-0002-6601-2165] subset: human_reference_atlas synonym: "canal of the cervix" RELATED [Wikipedia:Canal_of_the_cervix] synonym: "cavity of cervix" RELATED [BTO:0002249] synonym: "cervical canal" RELATED [Wikipedia:Canal_of_the_cervix] synonym: "cervical canal of uterus" RELATED [BTO:0002249] synonym: "endocervical" RELATED [Wikipedia:Canal_of_the_cervix] synonym: "endocervical canal" RELATED [BTO:0002249, Wikipedia:Canal_of_the_cervix] synonym: "endocervix" RELATED [Wikipedia:Canal_of_the_cervix] synonym: "lumen of cervix of uterus" EXACT [FMA:17746] xref: BTO:0002249 xref: FMA:17746 xref: Wikipedia:Canal_of_the_cervix is_a: UBERON:0002553 ! anatomical cavity intersection_of: UBERON:0002553 ! anatomical cavity intersection_of: RO:0002572 UBERON:0000002 ! luminal space of uterine cervix relationship: RO:0002572 UBERON:0000002 ! luminal space of uterine cervix property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0013765 name: digestive system element def: "Any of the organs or elements that are part of the digestive system. Examples: tongue, esophagus, spleen, crop, lunge feeding organ, tooth elements." [http://orcid.org/0000-0002-6601-2165] subset: grouping_class subset: pheno_slim synonym: "digestive organ" EXACT [] synonym: "digestive system organ" EXACT [] xref: EMAPA:37843 {source="MA:th"} xref: SCTID:272627002 is_a: UBERON:0000062 ! organ intersection_of: UBERON:0000062 ! organ intersection_of: BFO:0000050 UBERON:0001007 ! part of digestive system relationship: BFO:0000050 UBERON:0001007 ! part of digestive system property_value: skos:prefLabel "digestive system element" xsd:string [Term] id: UBERON:0013768 name: great vessel of heart def: "Great vessels is a term used to refer collectively to the large vessels that bring blood to and from the heart." [Wikipedia:Great_vessels] comment: Groupings may vary - typically pulmonary vessels and aorta and vena cavae subset: grouping_class synonym: "great vessel" BROAD [] synonym: "great vessel of thorax" EXACT [] xref: EMAPA:36460 xref: SCTID:304066000 xref: Wikipedia:Great_vessels is_a: UBERON:0001981 ! blood vessel property_value: skos:prefLabel "great vessel of heart" xsd:string [Term] id: UBERON:0013769 name: uterine lumen def: "An organ cavity that is part of a uterus." [OBOL:automatic] synonym: "cavity of uterus" EXACT [FMA:17745] synonym: "uterine cavity" EXACT [FMA:17745] synonym: "uterine space" EXACT [] xref: EMAPA:36273 xref: FMA:17745 xref: Wikipedia:Uterine_cavity is_a: UBERON:0002558 ! organ cavity intersection_of: UBERON:0002558 ! organ cavity intersection_of: BFO:0000050 UBERON:0000995 ! part of uterus relationship: BFO:0000050 UBERON:0000995 ! part of uterus [Term] id: UBERON:0013772 name: left nipple def: "A nipple that is in_the_left_side_of a body proper." [OBOL:automatic] subset: pheno_slim xref: FMA:223695 is_a: UBERON:0002030 ! nipple is_a: UBERON:0015212 ! lateral structure intersection_of: UBERON:0002030 ! nipple intersection_of: BSPO:0000120 UBERON:0013702 ! body proper relationship: BSPO:0000120 UBERON:0013702 ! body proper property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/mammary-gland-female-left/v1.1/assets/3d-vh-f-mammary-gland-l.glb" xsd:anyURI [Term] id: UBERON:0013773 name: right nipple def: "A nipple that is in_the_right_side_of a body proper." [OBOL:automatic] subset: pheno_slim xref: FMA:223693 is_a: UBERON:0002030 ! nipple is_a: UBERON:0015212 ! lateral structure intersection_of: UBERON:0002030 ! nipple intersection_of: BSPO:0000121 UBERON:0013702 ! body proper relationship: BSPO:0000121 UBERON:0013702 ! body proper property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/mammary-gland-female-right/v1.1/assets/3d-vh-f-mammary-gland-r.glb" xsd:anyURI [Term] id: UBERON:0013774 name: diaphysis of metatarsal bone def: "A diaphysis that is part of a metatarsal bone." [OBOL:automatic] subset: pheno_slim synonym: "diaphysis of metatarsal" EXACT [] synonym: "metatarsal bone diaphysis" EXACT [FMA:33826] synonym: "metatarsal diaphysis" EXACT [] synonym: "shaft of metatarsal bone" EXACT [FMA:33826] xref: FMA:33826 is_a: UBERON:0004769 ! diaphysis intersection_of: UBERON:0004769 ! diaphysis intersection_of: BFO:0000050 UBERON:0001448 ! part of metatarsal bone relationship: BFO:0000050 UBERON:0001448 ! part of metatarsal bone [Term] id: UBERON:0013776 name: skin of palmar/plantar part of autopod def: "A zone of skin that is part of a palmar/plantar part of autopod." [OBOL:automatic] is_a: UBERON:0015790 ! autopod skin intersection_of: UBERON:0000014 ! zone of skin intersection_of: BFO:0000050 UBERON:0008837 ! part of palmar/plantar part of autopod relationship: BFO:0000050 UBERON:0008837 ! part of palmar/plantar part of autopod [Term] id: UBERON:0013778 name: skin of sole of pes def: "A zone of skin that is part of a skin of pes." [OBOL:automatic] subset: pheno_slim synonym: "plantar skin of foot" EXACT [FMA:37849] synonym: "skin of plantar part of foot" EXACT [FMA:37849] synonym: "skin of sole of foot" EXACT [FMA:37849] xref: FMA:37849 xref: SCTID:181566006 is_a: UBERON:0001513 ! skin of pes is_a: UBERON:0013776 ! skin of palmar/plantar part of autopod intersection_of: UBERON:0000014 ! zone of skin intersection_of: BFO:0000050 UBERON:0008338 ! part of plantar part of pes relationship: BFO:0000050 UBERON:0008338 ! part of plantar part of pes [Term] id: UBERON:0014283 name: piriform cortex layer 3 def: "Deepest of 3 cytoarchitecturally defined layers of the piriform cortex characterized by a moderately high density of pyramidal cells and large numbers of basal dendrites descending from pyramidal cells in layer 2." [NLXANAT:091009] synonym: "layer 3 of piriform cortex" EXACT [NLXANAT:091009] synonym: "layer 3 of piriform cortex" RELATED [NLXANAT:091009] synonym: "piriform cortex layer 3" EXACT [NLXANAT:091009] xref: NLXANAT:091009 is_a: UBERON:0011215 ! central nervous system cell part cluster is_a: UBERON:0022303 ! nervous system cell part layer relationship: BFO:0000050 UBERON:0004725 {source="NIFSTD"} ! part of piriform cortex relationship: BFO:0000051 CL:0000598 ! has part pyramidal neuron property_value: skos:prefLabel "piriform cortex layer 3" xsd:string property_value: terms:contributor https://orcid.org/0000-0002-8406-3871 [Term] id: UBERON:0014371 name: future telencephalon def: "Embryonic structure that gives rise to the telencephalon." [ZFA:0000571, ZFA:curator] comment: paired anteriolateral division of the embryonic prosencephalon plus the lamina terminalis from which the olfactory lobes, cerebral cortex, and subcortical nuclei are derived[MP] synonym: "presumptive telencephalon" EXACT [ZFA:0000571] xref: EHDAA2:0004424 xref: EMAPA:36024 xref: TAO:0000571 xref: ZFA:0000571 is_a: BFO:0000002 is_a: UBERON:0006598 ! presumptive structure intersection_of: UBERON:0006598 ! presumptive structure intersection_of: RO:0002387 UBERON:0001893 ! has potential to develop into telencephalon relationship: BFO:0000050 UBERON:0006240 ! part of future forebrain relationship: RO:0002254 UBERON:0003850 {evidence="definitional"} ! has developmental contribution from telencephalon neural crest relationship: RO:0002387 UBERON:0001893 ! has potential to develop into telencephalon property_value: skos:prefLabel "future telencephalon" xsd:string [Term] id: UBERON:0014382 name: collection of hairs on head or neck def: "A collection of hairs that is part of a craniocervical region." [OBOL:automatic] is_a: UBERON:0010164 ! collection of hairs intersection_of: UBERON:0010164 ! collection of hairs intersection_of: BFO:0000050 UBERON:0007811 ! part of craniocervical region relationship: BFO:0000050 UBERON:0007811 ! part of craniocervical region [Term] id: UBERON:0014387 name: mesenchyme derived from neural crest def: "Mesenchyme that develops_from the neural crest[Automatically generated definition]." [https://github.com/obophenotype/uberon/issues/248, OBOL:automatic] synonym: "mesenchyme from neural crest" EXACT [] synonym: "neural crest derived mesenchyme" EXACT [] synonym: "neural crest mesenchyme" EXACT [] xref: EMAPA:32735 xref: FMA:293883 is_a: UBERON:0003104 ! mesenchyme is_a: UBERON:0010313 ! neural crest-derived structure intersection_of: UBERON:0003104 ! mesenchyme intersection_of: RO:0002202 UBERON:0002342 ! develops from neural crest property_value: skos:prefLabel "mesenchyme derived from neural crest" xsd:string [Term] id: UBERON:0014388 name: kidney collecting duct epithelium def: "The simple cuboidal epithelium lining the lumen of kidney collecting ducts." [MGI:anna, MP:0011843] subset: pheno_slim synonym: "collecting duct of renal tubule epithelium" EXACT [] synonym: "epithelium of collecting duct of renal tubule" EXACT [] synonym: "epithelium of renal collecting tubule" EXACT [] xref: EMAPA:37885 {source="MA:th"} is_a: UBERON:0000484 ! simple cuboidal epithelium is_a: UBERON:0004211 ! nephron epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: BFO:0000050 UBERON:0001232 ! part of collecting duct of renal tubule relationship: BFO:0000050 UBERON:0001232 ! part of collecting duct of renal tubule relationship: RO:0002433 UBERON:0001232 ! contributes to morphology of collecting duct of renal tubule [Term] id: UBERON:0014389 name: gustatory papilla of tongue def: "A papilla that contain taste buds, including the fungiform, foliate, and circumvallate papillae." [MGI:smb, MP:0006256] synonym: "gustatory papilla" EXACT [] synonym: "gustatory papillae" RELATED OMO:0003004 [] synonym: "taste papilla" EXACT [] synonym: "taste papillae" RELATED OMO:0003004 [] is_a: BFO:0000002 is_a: UBERON:0001726 ! papilla of tongue intersection_of: UBERON:0001726 ! papilla of tongue intersection_of: BFO:0000051 UBERON:0001727 ! has part taste bud relationship: BFO:0000051 UBERON:0001727 ! has part taste bud property_value: skos:prefLabel "gustatory papilla of tongue" xsd:string [Term] id: UBERON:0014390 name: muscle layer of ileum def: "A muscular coat that is part of a ileum." [OBOL:automatic] synonym: "ileal smooth muscle" RELATED [https://orcid.org/0000-0002-6601-2165] synonym: "muscularis externa of ileum" EXACT [FMA:14958] synonym: "muscularis propria of ileum" RELATED [https://orcid.org/0000-0002-6601-2165] synonym: "smooth muscle of ileum" RELATED [https://orcid.org/0000-0002-6601-2165] xref: BTO:0005574 xref: FMA:14958 is_a: UBERON:0011201 ! muscle layer of small intestine intersection_of: UBERON:0006660 ! muscular coat intersection_of: BFO:0000050 UBERON:0002116 ! part of ileum relationship: BFO:0000050 UBERON:0002116 ! part of ileum [Term] id: UBERON:0014391 name: palmar/plantar sweat gland def: "A sweat gland that is part of the skin of the palmar part of the manus or plantar part of the pes." [http://orcid.org/0000-0002-6601-2165] synonym: "palm sweat gland" NARROW [] synonym: "palm/sole sweat gland" RELATED [] synonym: "palmar eccrine sweat gland" NARROW [] synonym: "palmar/plantar eccrine sweat gland" RELATED [] synonym: "sweat gland of palmar part of manus" NARROW [] synonym: "sweat gland of palmar/plant part of autopod" RELATED [] is_a: UBERON:0000423 ! eccrine sweat gland intersection_of: UBERON:0001820 ! sweat gland intersection_of: BFO:0000050 UBERON:0008837 ! part of palmar/plantar part of autopod relationship: BFO:0000050 UBERON:0008837 ! part of palmar/plantar part of autopod [Term] id: UBERON:0014392 name: sweat of palm def: "Sweat that is produced by the glands on the palmar and plantar surfaces." [http://orcid.org/0000-0002-6601-2165] synonym: "palm sweat" EXACT [FMA:63084] synonym: "palmar sweat" EXACT [FMA:63084] xref: FMA:63084 is_a: UBERON:0001089 ! sweat intersection_of: UBERON:0001089 ! sweat intersection_of: RO:0003001 UBERON:0014391 ! produced by palmar/plantar sweat gland relationship: RO:0003001 UBERON:0014391 ! produced by palmar/plantar sweat gland [Term] id: UBERON:0014393 name: sweat of axilla def: "Sweat that is produced by the glands of the axilla." [http://orcid.org/0000-0002-6601-2165] synonym: "axillary sweat" EXACT [FMA:63085] xref: FMA:63085 is_a: UBERON:0001089 ! sweat intersection_of: UBERON:0001089 ! sweat intersection_of: RO:0003001 UBERON:0018232 ! produced by axillary sweat gland relationship: RO:0003001 UBERON:0018232 ! produced by axillary sweat gland [Term] id: UBERON:0014395 name: proximal mesopodial bone def: "A proximal mesopodial endochondral element that is composed primarily of a bone tissue." [OBOL:automatic] is_a: UBERON:0003656 ! mesopodium bone is_a: UBERON:0017750 ! proximal mesopodial endochondral element intersection_of: UBERON:0017750 ! proximal mesopodial endochondral element intersection_of: RO:0002473 UBERON:0002481 ! composed primarily of bone tissue relationship: RO:0002202 UBERON:0017751 ! develops from proximal mesopodial cartilage element [Term] id: UBERON:0014398 name: respiratory muscle def: "Muscle that is part of the respiratory system." [http://orcid.org/0000-0002-6601-2165] subset: pheno_slim is_a: UBERON:0003831 ! respiratory system muscle intersection_of: UBERON:0001630 ! muscle organ intersection_of: RO:0002216 GO:0007585 ! capable of part of respiratory gaseous exchange by respiratory system relationship: RO:0002216 GO:0007585 ! capable of part of respiratory gaseous exchange by respiratory system relationship: RO:0002473 UBERON:0001134 ! composed primarily of skeletal muscle tissue property_value: skos:prefLabel "respiratory muscle" xsd:string [Term] id: UBERON:0014399 name: sinusoidal space def: "An anatomical space that is enclosed by a sinusoid." [OBOL:automatic] synonym: "lumen of sinusoid" EXACT [FMA:63133] synonym: "sinusoid lumen" EXACT [FMA:63133] xref: FMA:63133 is_a: UBERON:0010161 ! lumen of blood vessel intersection_of: UBERON:0000464 ! anatomical space intersection_of: RO:0002572 UBERON:0003909 ! luminal space of sinusoid relationship: RO:0002572 UBERON:0003909 ! luminal space of sinusoid [Term] id: UBERON:0014400 name: hepatic sinusoidal space def: "A sinusoidal space that is part of a hepatic sinusoid." [OBOL:automatic] synonym: "lumen of hepatic sinusoid" EXACT [FMA:262090] xref: FMA:262090 is_a: UBERON:0014399 ! sinusoidal space intersection_of: UBERON:0014399 ! sinusoidal space intersection_of: BFO:0000050 UBERON:0001281 ! part of hepatic sinusoid relationship: BFO:0000050 UBERON:0001281 ! part of hepatic sinusoid [Term] id: UBERON:0014401 name: renal venous blood vessel def: "Any member of the network of tubes that return blood from the renal tissues to the systemic circulation." [MGI:csmith] subset: pheno_slim synonym: "kidney venous blood vessel" EXACT [MA:0002591] synonym: "kidney venous system" RELATED [EMAPA:31450] synonym: "venous blood vessel of kidney" EXACT [] xref: EMAPA:31450 xref: MA:0002591 is_a: UBERON:0003517 ! kidney blood vessel is_a: UBERON:0003920 ! venous blood vessel intersection_of: UBERON:0003920 ! venous blood vessel intersection_of: BFO:0000050 UBERON:0002113 ! part of kidney [Term] id: UBERON:0014402 name: sex-specific anatomical structure def: "A part of the body present only in a specific gender." [AEO:0000174, AEO:JB] synonym: "gender-specific" EXACT [] synonym: "gender-specific anatomical structure" EXACT [AEO:0000174] synonym: "sex-specific" EXACT [] xref: AEO:0000174 xref: WBbt:0005752 is_a: BFO:0000002 is_a: UBERON:0000061 ! anatomical structure intersection_of: UBERON:0000061 ! anatomical structure intersection_of: RO:0002353 GO:0007548 ! output of sex differentiation relationship: RO:0002353 GO:0007548 ! output of sex differentiation [Term] id: UBERON:0014403 name: male anatomical structure def: "A part of the body present only in males." [AEO:0000175, AEO:JB] synonym: "male-specific" RELATED [WBbt:0005757] synonym: "male-specific structure" EXACT [] xref: AEO:0000175 xref: WBbt:0005757 is_a: UBERON:0014402 ! sex-specific anatomical structure intersection_of: UBERON:0014402 ! sex-specific anatomical structure intersection_of: BFO:0000050 UBERON:0003101 ! part of male organism relationship: BFO:0000050 UBERON:0003101 ! part of male organism [Term] id: UBERON:0014404 name: female anatomical structure def: "A part of the body present only in females." [AEO:0000176, AEO:JB] xref: AEO:0000176 is_a: UBERON:0014402 ! sex-specific anatomical structure intersection_of: UBERON:0014402 ! sex-specific anatomical structure intersection_of: BFO:0000050 UBERON:0003100 ! part of female organism relationship: BFO:0000050 UBERON:0003100 ! part of female organism [Term] id: UBERON:0014450 name: pretectal nucleus def: "A neural nucleus of the pretectal area (between dorsal thalamus and optic tectum) that receives afferents primarily from the retina and the optic tectum and are involved in modulating motor behavior in response to visual input." [https://github.com/obophenotype/uberon/issues/361, ISBN:0471888893] subset: pheno_slim synonym: "nucleus area pretectalis" RELATED OMO:0003011 [NeuroNames:468] synonym: "nucleus of pretectal area" EXACT [FMA:72401] synonym: "nucleus of the pretectal area" RELATED [NeuroNames:468] synonym: "pretectal area nucleus" EXACT [FMA:72401] synonym: "pretectal nucleus" EXACT [] xref: BAMS:PTA xref: BIRNLEX:864 xref: DHBA:12182 xref: EMAPA:37919 {source="MA:th"} xref: FMA:72401 xref: HBA:9083 xref: neuronames:468 {source="BIRNLEX:864"} xref: SCTID:416164009 xref: UMLS:C0175358 {source="BIRNLEX:864"} is_a: UBERON:0002308 ! nucleus of brain intersection_of: UBERON:0002308 ! nucleus of brain intersection_of: BFO:0000050 UBERON:0001944 ! part of pretectal region relationship: BFO:0000050 UBERON:0001944 ! part of pretectal region property_value: RO:0002175 NCBITaxon:7761 property_value: RO:0002175 NCBITaxon:9255 property_value: skos:prefLabel "pretectal nucleus" xsd:string property_value: terms:contributor https://orcid.org/0000-0002-6601-2165 [Term] id: UBERON:0014451 name: tongue taste bud def: "A taste bud that is located on the tongue, situated on a gustatory papilla." [http://orcid.org/0000-0002-6601-2165] subset: human_reference_atlas subset: pheno_slim synonym: "gustatory papilla taste bud" EXACT [] synonym: "gustatory papillae taste bud" EXACT [MP:0006260] is_a: UBERON:0001727 ! taste bud is_a: UBERON:0013765 ! digestive system element intersection_of: UBERON:0001727 ! taste bud intersection_of: BFO:0000050 UBERON:0001723 ! part of tongue relationship: BFO:0000050 UBERON:0014389 ! part of gustatory papilla of tongue property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "tongue taste bud" xsd:string [Term] id: UBERON:0014452 name: gustatory epithelium of tongue def: "A gustatory epithelium that is part of a tongue." [OBOL:automatic] subset: human_reference_atlas synonym: "lingual gustatory epithelium" EXACT [http://orcid.org/0000-0002-6601-2165] xref: BIRNLEX:4099 xref: UMLS:C1179150 {source="BIRNLEX:4099"} is_a: UBERON:0002926 ! gustatory epithelium is_a: UBERON:0003357 ! epithelium of tongue intersection_of: UBERON:0002926 ! gustatory epithelium intersection_of: BFO:0000050 UBERON:0001723 ! part of tongue property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "gustatory epithelium of tongue" xsd:string [Term] id: UBERON:0014453 name: gustatory epithelium of palate def: "A gustatory epithelium that is part of a roof of mouth." [OBOL:automatic] synonym: "palatal gustatory epithelium" EXACT [http://orcid.org/0000-0002-6601-2165] is_a: UBERON:0002424 ! oral epithelium is_a: UBERON:0002926 ! gustatory epithelium intersection_of: UBERON:0002926 ! gustatory epithelium intersection_of: BFO:0000050 UBERON:0007375 ! part of roof of mouth relationship: BFO:0000050 UBERON:0002424 ! part of oral epithelium relationship: BFO:0000050 UBERON:0007375 ! part of roof of mouth property_value: skos:prefLabel "gustatory epithelium of palate" xsd:string [Term] id: UBERON:0014454 name: visceral abdominal adipose tissue def: "Subcutaneous adipose tissue that is located in the peritoneal cavity." [CALOHA:paula, http://orcid.org/0000-0002-6601-2165, https://github.com/obophenotype/uberon/issues/259, MGI:csmith] synonym: "abdominal fat" RELATED [BTO:0004041] synonym: "intra-abdominal adipose tissue" RELATED [] synonym: "intra-abdominal fat" RELATED [BTO:0004041] synonym: "organ fat" RELATED [BTO:0004041] synonym: "visceral adipose tissue" RELATED [BTO:0004041] synonym: "visceral fat" RELATED [BTO:0004041] xref: BTO:0004041 xref: CALOHA:TS-2405 is_a: UBERON:0007808 ! adipose tissue of abdominal region intersection_of: UBERON:0001013 ! adipose tissue intersection_of: BFO:0000050 UBERON:0000916 ! part of abdomen intersection_of: RO:0001025 UBERON:0001179 ! located in peritoneal cavity intersection_of: RO:0002007 UBERON:0002075 ! bounding layer of viscus relationship: RO:0001025 UBERON:0001179 ! located in peritoneal cavity relationship: RO:0002007 UBERON:0002075 ! bounding layer of viscus property_value: skos:prefLabel "visceral abdominal adipose tissue" xsd:string property_value: terms:contributor https://orcid.org/0000-0002-0819-0473 property_value: terms:contributor https://orcid.org/0000-0002-6601-2165 [Term] id: UBERON:0014455 name: subcutaneous abdominal adipose tissue def: "Subcutaneous adipose tissue that is located in the abdominal region." [CALOHA:paula, http://orcid.org/0000-0002-6601-2165, https://github.com/obophenotype/uberon/issues/259, MGI:csmith] synonym: "abdominal subcutaneous adipose tissue" EXACT [] synonym: "subcutaneous abdominal fat" EXACT [] synonym: "subcutaneous fat of abdominal region" EXACT [] xref: CALOHA:TS-2406 is_a: UBERON:0002190 ! subcutaneous adipose tissue is_a: UBERON:0007808 ! adipose tissue of abdominal region intersection_of: UBERON:0001013 ! adipose tissue intersection_of: BFO:0000050 UBERON:0000916 ! part of abdomen intersection_of: BFO:0000050 UBERON:0002072 ! part of hypodermis property_value: skos:prefLabel "subcutaneous abdominal adipose tissue" xsd:string property_value: terms:contributor https://orcid.org/0000-0002-0819-0473 property_value: terms:contributor https://orcid.org/0000-0002-6601-2165 [Term] id: UBERON:0014463 name: cardiac ganglion def: "Any of the parasympathetic ganglia of the cardiac plexus between the arch of the aorta and the bifurcation of the pulmonary artery." [ISBN:0-683-40008-8, MP:0003685] subset: human_reference_atlas synonym: "cardiac ganglia" RELATED OMO:0003004 [] synonym: "cardiac ganglia set" EXACT [FMA:77582] synonym: "cardiac ganglion of Wrisberg" EXACT [] synonym: "ganglia cardiaca" EXACT [FMA:TA] synonym: "ganglion of Wrisberg" EXACT [FMA:77582] synonym: "Wrisberg ganglion" EXACT [MP:0003685] xref: EMAPA:36644 xref: FMA:77582 xref: SCTID:57098005 is_a: UBERON:0001808 ! parasympathetic ganglion intersection_of: UBERON:0001808 ! parasympathetic ganglion intersection_of: extends_fibers_into UBERON:0002008 ! cardiac nerve plexus relationship: extends_fibers_into UBERON:0002008 ! cardiac nerve plexus property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0014466 name: subarachnoid fissure xref: FMA:75136 is_a: UBERON:0000464 ! anatomical space relationship: BFO:0000050 UBERON:0000315 ! part of subarachnoid space property_value: skos:prefLabel "subarachnoid fissure" xsd:string [Term] id: UBERON:0014477 name: thoracic skeleton def: "Subdivision of skeletal system that consists of all skeletal elements in the thoracic region of the trunk. In most vertebrates this is the rib cage and sternum." [https://orcid.org/0000-0002-6601-2165, Wikipedia:Rib_cage] subset: human_reference_atlas subset: pheno_slim synonym: "skeleton of thorax" EXACT [] synonym: "thoracic part of axial skeleton" EXACT [] synonym: "thoracic skeleton" EXACT [EHDAA2:0002013] xref: EHDAA2:0002013 xref: FMA:77169 xref: Wikipedia:Thoracic_skeleton is_a: UBERON:0010912 ! subdivision of skeleton relationship: BFO:0000050 UBERON:0000915 ! part of thoracic segment of trunk relationship: BFO:0000050 UBERON:0002090 ! part of postcranial axial skeleton property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "thoracic skeleton" xsd:string [Term] id: UBERON:0014478 name: rib skeletal system def: "Subdivision of skeletal system that consists of all ribs and rib joints in an organism. In many vertebrates this consists of the combination of the rib cage and all rib joints, but some vertebrates have ribs outside the thoracic rib cage." [https://orcid.org/0000-0002-6601-2165] synonym: "rib series" EXACT [TAO:0002100] synonym: "rib skeleton" RELATED [] synonym: "set of all ribs" RELATED [FMA:265719] xref: FMA:265719 xref: TAO:0002100 is_a: BFO:0000002 is_a: UBERON:0000075 ! subdivision of skeletal system relationship: BFO:0000050 UBERON:0011138 ! part of postcranial axial skeletal system relationship: BFO:0000051 UBERON:0003252 ! has part thoracic rib cage relationship: RO:0002473 UBERON:0015019 ! composed primarily of rib endochondral element property_value: RO:0002161 NCBITaxon:7778 {source="Wikipedia"} [Term] id: UBERON:0014530 name: white matter lamina of neuraxis synonym: "lamina of neuraxis" BROAD [FMA:83856] synonym: "neuraxis lamina" BROAD [FMA:83856] xref: FMA:83856 is_a: UBERON:0011215 ! central nervous system cell part cluster is_a: UBERON:0022303 ! nervous system cell part layer intersection_of: UBERON:0022303 ! nervous system cell part layer intersection_of: BFO:0000050 UBERON:0002316 ! part of white matter relationship: BFO:0000050 UBERON:0002316 ! part of white matter property_value: skos:prefLabel "white matter lamina of neuraxis" xsd:string [Term] id: UBERON:0014531 name: white matter lamina of diencephalon synonym: "diencephalon lamina" BROAD [FMA:62449] synonym: "lamina of diencephalon" BROAD [FMA:62449] xref: FMA:62449 is_a: UBERON:0014530 ! white matter lamina of neuraxis intersection_of: UBERON:0014530 ! white matter lamina of neuraxis intersection_of: BFO:0000050 UBERON:0001894 ! part of diencephalon relationship: BFO:0000050 UBERON:0001894 ! part of diencephalon property_value: skos:prefLabel "white matter lamina of diencephalon" xsd:string [Term] id: UBERON:0014532 name: white matter lamina of cerebral hemisphere synonym: "cerebral hemisphere lamina" BROAD [FMA:67951] synonym: "lamina of cerebral hemisphere" BROAD [FMA:67951] xref: FMA:67951 is_a: UBERON:0014530 ! white matter lamina of neuraxis intersection_of: UBERON:0014530 ! white matter lamina of neuraxis intersection_of: BFO:0000050 UBERON:0001869 ! part of cerebral hemisphere relationship: BFO:0000050 UBERON:0001869 ! part of cerebral hemisphere property_value: skos:prefLabel "white matter lamina of cerebral hemisphere" xsd:string [Term] id: UBERON:0014538 name: subdivision of spinal cord central canal def: "A subdivision of the central canal of the spinal cord along its anterior-posterior axis. This is typically subdivided into cervical, thoracic, lumbar and sacral segments." [http://orcid.org/0000-0002-6601-2165] subset: non_informative synonym: "regional part of spinal cord central canal" EXACT HUMAN_PREFERRED [BIRNLEX:717] xref: BIRNLEX:717 is_a: UBERON:0004111 ! anatomical conduit intersection_of: UBERON:0004111 ! anatomical conduit intersection_of: subdivision_of UBERON:0002291 ! central canal of spinal cord relationship: BFO:0000050 UBERON:0002291 ! part of central canal of spinal cord relationship: subdivision_of UBERON:0002291 ! central canal of spinal cord property_value: skos:prefLabel "subdivision of spinal cord central canal" xsd:string [Term] id: UBERON:0014540 name: white matter lamina of cerebellum def: "The white laminae of cerebellum is subdivision of the cerebellar cortex comprised of myelinated axons lying deep to the granule cell layer of the cerebellar cortex." [http://neurolex.org/wiki/Category\:White_laminae_of_cerebellum] synonym: "isthmus cinguli" RELATED OMO:0003011 [NeuroNames:163] synonym: "isthmus gyri cingulatus" RELATED OMO:0003011 [NeuroNames:163] synonym: "isthmus gyri cinguli" RELATED OMO:0003011 [NeuroNames:163] synonym: "isthmus of gyrus fornicatus" RELATED OMO:0003011 [NeuroNames:163] synonym: "isthmus of the cingulate gyrus" RELATED [NeuroNames:163] synonym: "isthmus-2" RELATED OMO:0003011 [NeuroNames:163] synonym: "lamina alba of cerebellar cortex" EXACT [] synonym: "laminae albae of cerebellar cortex" EXACT [] synonym: "laminae albae of cerebellar cortex" RELATED OMO:0003004 [BIRNLEX:1105] synonym: "white lamina of cerebellum" EXACT [] synonym: "white laminae of cerebellum" EXACT OMO:0003004 [BIRNLEX:1105] xref: BIRNLEX:1105 xref: neuronames:163 {source="BIRNLEX:1105"} xref: SCTID:362413004 xref: UMLS:C0228472 {source="BIRNLEX:1105"} is_a: UBERON:0014530 ! white matter lamina of neuraxis intersection_of: UBERON:0014530 ! white matter lamina of neuraxis intersection_of: BFO:0000050 UBERON:0002037 ! part of cerebellum relationship: BFO:0000050 UBERON:0002037 ! part of cerebellum relationship: BSPO:0001107 UBERON:0002956 ! granular layer of cerebellar cortex property_value: skos:prefLabel "white matter lamina of cerebellum" xsd:string [Term] id: UBERON:0014541 name: thoracic division of spinal cord central canal def: "Part of spinal cord central canal contained in the thoracic spinal cord. It is continuous rostrally with the cervical spinal cord central canal and caudally with the lumbar spinal cord central canal." [BIRNLEX:1395] subset: human_reference_atlas synonym: "thoracic spinal cord central canal" EXACT HUMAN_PREFERRED [BIRNLEX:1395] xref: BIRNLEX:1395 xref: FMA:321588 xref: SCTID:71118002 xref: UMLS:C0228637 {source="BIRNLEX:1395"} is_a: UBERON:0014538 {source="NIFSTD"} ! subdivision of spinal cord central canal intersection_of: UBERON:0014538 ! subdivision of spinal cord central canal intersection_of: subdivision_of UBERON:0003038 ! thoracic spinal cord relationship: subdivision_of UBERON:0003038 ! thoracic spinal cord property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "thoracic division of spinal cord central canal" xsd:string [Term] id: UBERON:0014542 name: cervical division of cord spinal central canal def: "Part of central canal contained within the cervical spinal cord. It is continuous caudally with the thoracic spinal cord central canal and rostrally with the fourth ventricle of the brain via the obex." [BIRNLEX:1511] synonym: "cervical spinal cord central canal" EXACT HUMAN_PREFERRED [BIRNLEX:1511] xref: BIRNLEX:1511 xref: FMA:321590 xref: SCTID:280403009 xref: UMLS:C0228620 {source="BIRNLEX:1511"} is_a: UBERON:0014538 {source="NIFSTD"} ! subdivision of spinal cord central canal intersection_of: UBERON:0014538 ! subdivision of spinal cord central canal intersection_of: subdivision_of UBERON:0002726 ! cervical spinal cord relationship: subdivision_of UBERON:0002726 ! cervical spinal cord property_value: skos:prefLabel "cervical division of cord spinal central canal" xsd:string [Term] id: UBERON:0014543 name: lumbar division of spinal cord central canal def: "Part of central canal lying within the lumbar spinal cord. It is continuous rostrally with the central canal of the thoracic spinal cord and caudally with the central canal of the sacral spinal cord." [BIRNLEX:1604] subset: human_reference_atlas synonym: "lumbar spinal cord central canal" EXACT HUMAN_PREFERRED [BIRNLEX:1604] xref: BIRNLEX:1604 xref: FMA:321589 xref: SCTID:280406001 xref: UMLS:C0228644 {source="BIRNLEX:1604"} is_a: UBERON:0014538 {source="NIFSTD"} ! subdivision of spinal cord central canal intersection_of: UBERON:0014538 ! subdivision of spinal cord central canal intersection_of: subdivision_of UBERON:0002792 ! lumbar spinal cord relationship: subdivision_of UBERON:0002792 ! lumbar spinal cord property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0014547 name: sacral division of spinal cord central canal def: "Part of spinal cord central canal contained in the sacral spinal cord. It is continuous rostrally with the spinal cord central canal of the lumbar cord." [NLXANAT:1010008] subset: human_reference_atlas synonym: "lumbosacral spinal cord central canal" RELATED [] synonym: "sacral spinal cord central canal" EXACT HUMAN_PREFERRED [NLXANAT:1010008] xref: FMA:321696 xref: NLXANAT:1010008 xref: SCTID:362450003 is_a: UBERON:0014538 ! subdivision of spinal cord central canal intersection_of: UBERON:0014538 ! subdivision of spinal cord central canal intersection_of: subdivision_of UBERON:0005843 ! sacral spinal cord relationship: subdivision_of UBERON:0005843 ! sacral spinal cord property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0014550 name: pyramidal layer of CA3 def: "A layer of hippocampal field that is part of a hippocampus pyramidal layer and is part of a CA3 field of hippocampus." [OBOL:automatic] synonym: "CA3 part of stratum pyramidale hippocampi" EXACT HUMAN_PREFERRED [BIRNLEX:4112] synonym: "CA3 stratum pyramidale hippocampi" EXACT [BIRNLEX:4112] synonym: "field CA3, pyramidal layer" EXACT [ABA:CA3sp] synonym: "stratum pyramidale of CA3" EXACT [PBA:10070] synonym: "stratum pyramidale of the CA3 field" EXACT [NeuroNames:2950] xref: BIRNLEX:4112 xref: EMAPA:36448 xref: FMA:277872 xref: MBA:495 xref: neuronames:2950 xref: PBA:10070 is_a: UBERON:0035788 ! layer of CA3 field intersection_of: UBERON:0035788 ! layer of CA3 field intersection_of: BFO:0000050 UBERON:0002313 ! part of hippocampus pyramidal layer relationship: BFO:0000050 UBERON:0002313 ! part of hippocampus pyramidal layer relationship: BSPO:0001107 UBERON:0007637 {source="NN-text"} ! hippocampus stratum lucidum property_value: skos:prefLabel "pyramidal layer of CA3" xsd:string [Term] id: UBERON:0014553 name: CA3 stratum oriens def: "Part of stratum oriens lying in area CA3 deep to the CA3 pyramidal cell layer and continuous with stratum oriens of area CA2 and bounded by the dentate gyrus hilus." [BIRNLEX:4117] synonym: "CA3 part of stratum oriens" EXACT HUMAN_PREFERRED [BIRNLEX:4117] synonym: "CA3 stratum oriens" EXACT [BIRNLEX:4117] synonym: "oriens layer of CA3 field" EXACT [FMA:277860] synonym: "stratum oriens of the CA3 field" EXACT [NeuroNames:2949] xref: BAMS:so xref: BIRNLEX:4117 xref: DMBA:16142 xref: FMA:277860 xref: MBA:486 xref: neuronames:2949 xref: PBA:10069 is_a: UBERON:0035788 ! layer of CA3 field intersection_of: UBERON:0035788 ! layer of CA3 field intersection_of: BFO:0000050 UBERON:0005371 ! part of hippocampus stratum oriens relationship: BFO:0000050 UBERON:0005371 ! part of hippocampus stratum oriens property_value: skos:prefLabel "CA3 stratum oriens" xsd:string [Term] id: UBERON:0014556 name: CA3 stratum radiatum def: "Part of stratum radiatum in area CA3, lying superficial to the stratum lucidum and deep to CA3 stratum lacunosum-moleculare." [BIRNLEX:4121] synonym: "CA3 part of stratum radiatum" EXACT HUMAN_PREFERRED [BIRNLEX:4121] synonym: "CA3 stratum radiatum" EXACT [BIRNLEX:4121] synonym: "radiate layer of CA3 field" EXACT [FMA:277866] synonym: "stratum radiatum of the CA3 field" EXACT [NeuroNames:2952] xref: BAMS:sr xref: BIRNLEX:4121 xref: DMBA:16145 xref: FMA:277866 xref: MBA:504 xref: neuronames:2952 xref: PBA:10072 is_a: UBERON:0035788 ! layer of CA3 field intersection_of: UBERON:0035788 ! layer of CA3 field intersection_of: BFO:0000050 UBERON:0005372 ! part of hippocampus stratum radiatum relationship: BFO:0000050 UBERON:0005372 ! part of hippocampus stratum radiatum property_value: skos:prefLabel "CA3 stratum radiatum" xsd:string [Term] id: UBERON:0014571 name: CA3 alveus def: "Part of alveus lying within hippocampal sector CA3." [NLXANAT:1005039] synonym: "alveus of the CA3 field" EXACT [NeuroNames:2948] xref: FMA:277878 xref: neuronames:2948 xref: NLXANAT:1005039 is_a: UBERON:0035788 ! layer of CA3 field intersection_of: UBERON:0035788 ! layer of CA3 field intersection_of: BFO:0000050 UBERON:0007639 ! part of hippocampus alveus relationship: BFO:0000050 UBERON:0007639 ! part of hippocampus alveus property_value: skos:prefLabel "CA3 alveus" xsd:string [Term] id: UBERON:0014609 name: thoracic spinal cord dorsal horn def: "A dorsal horn of spinal cord that is part of a thoracic spinal cord." [OBOL:automatic] subset: human_reference_atlas synonym: "thoracic spinal cord dorsal horn" EXACT HUMAN_PREFERRED [BIRNLEX:1404] synonym: "thoracic spinal cord posterior horn" RELATED [BIRNLEX:1404] xref: BIRNLEX:1404 xref: SCTID:362442007 xref: UMLS:C0228628 {source="BIRNLEX:1404"} is_a: UBERON:0002256 ! dorsal horn of spinal cord intersection_of: UBERON:0002256 ! dorsal horn of spinal cord intersection_of: BFO:0000050 UBERON:0003038 ! part of thoracic spinal cord relationship: BFO:0000050 UBERON:0003038 ! part of thoracic spinal cord property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0014610 name: thoracic spinal cord ventral horn def: "A ventral horn of spinal cord that is part of a thoracic spinal cord." [OBOL:automatic] subset: human_reference_atlas synonym: "thoracic spinal cord anterior horn" RELATED [BIRNLEX:1410] synonym: "thoracic spinal cord ventral horn" EXACT HUMAN_PREFERRED [BIRNLEX:1410] xref: BIRNLEX:1410 xref: SCTID:367876000 xref: UMLS:C0228632 {source="BIRNLEX:1410"} xref: UMLS:C1288552 {source="BIRNLEX:1410"} is_a: UBERON:0002257 ! ventral horn of spinal cord intersection_of: UBERON:0002257 ! ventral horn of spinal cord intersection_of: BFO:0000050 UBERON:0003038 ! part of thoracic spinal cord relationship: BFO:0000050 UBERON:0003038 ! part of thoracic spinal cord property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0014613 name: cervical spinal cord gray matter def: "A gray matter of spinal cord that is part of a cervical spinal cord." [OBOL:automatic] subset: human_reference_atlas synonym: "cervical spinal cord gray matter" EXACT HUMAN_PREFERRED [BIRNLEX:1521] xref: BIRNLEX:1521 xref: SCTID:362438009 xref: UMLS:C0228610 {source="BIRNLEX:1521"} is_a: UBERON:0002315 ! gray matter of spinal cord intersection_of: UBERON:0002315 ! gray matter of spinal cord intersection_of: BFO:0000050 UBERON:0002726 ! part of cervical spinal cord relationship: BFO:0000050 UBERON:0002726 ! part of cervical spinal cord property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "cervical spinal cord gray matter" xsd:string [Term] id: UBERON:0014614 name: cervical spinal cord white matter def: "A white matter of spinal cord that is part of a cervical spinal cord." [OBOL:automatic] subset: human_reference_atlas synonym: "cervical spinal cord white matter" EXACT HUMAN_PREFERRED [BIRNLEX:1531] xref: BIRNLEX:1531 xref: SCTID:174829001 xref: UMLS:C0228616 {source="BIRNLEX:1531"} is_a: UBERON:0002318 ! white matter of spinal cord intersection_of: UBERON:0002318 ! white matter of spinal cord intersection_of: BFO:0000050 UBERON:0002726 ! part of cervical spinal cord relationship: BFO:0000050 UBERON:0002726 ! part of cervical spinal cord property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "cervical spinal cord white matter" xsd:string [Term] id: UBERON:0014615 name: accessory nerve root def: "A nerve root that is part of a accessory XI nerve." [OBOL:automatic] synonym: "accessory nerve root" EXACT HUMAN_PREFERRED [BIRNLEX:1580] synonym: "accessory portion of spinal accessory nerve" RELATED [NeuroNames:703] synonym: "bulbar accessory nerve" RELATED [NeuroNames:703] synonym: "bulbar part of accessory nerve" RELATED [NeuroNames:703] synonym: "c11n" BROAD OMO:0003000 [BIRNLEX:1580, NIFSTD:NeuroNames_abbrevSource] synonym: "cranial accessory nerve" RELATED [NeuroNames:703] synonym: "cranial part of accessory nerve" RELATED [BAMS:c11n] synonym: "cranial part of the accessory nerve" RELATED [NeuroNames:703] synonym: "cranial portion of eleventh cranial nerve" RELATED [NeuroNames:703] synonym: "internal branch of accessory nerve" RELATED [NeuroNames:703] synonym: "nerve XI (cranialis)" RELATED [NeuroNames:703] synonym: "pars vagalis of nervus accessorius" RELATED OMO:0003011 [NeuroNames:703] synonym: "radices craniales nervi accessorii" RELATED OMO:0003011 [NeuroNames:703] synonym: "root of accessory nerve" EXACT [] xref: BAMS:c11n xref: BIRNLEX:1580 xref: DHBA:12883 xref: DMBA:17749 xref: HBA:9340 xref: neuronames:703 {source="BIRNLEX:1580"} xref: SCTID:280187004 xref: Wikipedia:Cranial_root_of_accessory_nerves is_a: UBERON:0002211 ! nerve root intersection_of: UBERON:0002211 ! nerve root intersection_of: extends_fibers_into UBERON:0002019 ! accessory XI nerve relationship: extends_fibers_into UBERON:0002019 ! accessory XI nerve property_value: skos:prefLabel "accessory nerve root" xsd:string [Term] id: UBERON:0014620 name: cervical spinal cord dorsal horn def: "A dorsal horn of spinal cord that is part of a cervical spinal cord." [OBOL:automatic] subset: human_reference_atlas synonym: "cervical spinal cord dorsal horn" EXACT HUMAN_PREFERRED [BIRNLEX:1673] synonym: "cervical spinal cord posterior horn" RELATED [BIRNLEX:1673] xref: BIRNLEX:1673 xref: SCTID:362439001 xref: UMLS:C0228611 {source="BIRNLEX:1673"} is_a: UBERON:0002256 ! dorsal horn of spinal cord intersection_of: UBERON:0002256 ! dorsal horn of spinal cord intersection_of: BFO:0000050 UBERON:0002726 ! part of cervical spinal cord relationship: BFO:0000050 UBERON:0002726 ! part of cervical spinal cord property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0014621 name: cervical spinal cord ventral horn def: "A ventral horn of spinal cord that is part of a cervical spinal cord." [OBOL:automatic] subset: human_reference_atlas synonym: "cervical spinal cord anterior horn" RELATED [BIRNLEX:1680] synonym: "cervical spinal cord ventral horn" EXACT HUMAN_PREFERRED [BIRNLEX:1680] xref: BIRNLEX:1680 xref: MESH:D066151 {sssom:mapping_justification="https://w3id.org/semapv/vocab/LexicalMatching"} xref: SCTID:174363005 xref: UMLS:C0228615 {source="BIRNLEX:1680"} xref: UMLS:C1278740 {source="BIRNLEX:1680"} is_a: UBERON:0002257 ! ventral horn of spinal cord intersection_of: UBERON:0002257 ! ventral horn of spinal cord intersection_of: BFO:0000050 UBERON:0002726 ! part of cervical spinal cord relationship: BFO:0000050 UBERON:0002726 ! part of cervical spinal cord property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0014635 name: dorsal nerve root of cervical spinal cord def: "A dorsal root of spinal cord that overlaps a cervical spinal cord." [OBOL:automatic] synonym: "dorsal nerve root of cervical spinal cord" EXACT HUMAN_PREFERRED [BIRNLEX:964] synonym: "posterior nerve root of cervical spinal cord" RELATED [BIRNLEX:964] xref: BIRNLEX:964 xref: SCTID:175023008 xref: UMLS:C1278751 {source="BIRNLEX:964"} is_a: UBERON:0002261 ! dorsal root of spinal cord is_a: UBERON:0009632 {source="NIFSTD"} ! root of cervical nerve intersection_of: UBERON:0002261 ! dorsal root of spinal cord intersection_of: RO:0002131 UBERON:0002726 ! overlaps cervical spinal cord relationship: RO:0002131 UBERON:0002726 ! overlaps cervical spinal cord [Term] id: UBERON:0014636 name: thoracic spinal cord gray matter def: "A gray matter of spinal cord that is part of a thoracic spinal cord." [OBOL:automatic] subset: human_reference_atlas synonym: "thoracic spinal cord gray matter" EXACT HUMAN_PREFERRED [BIRNLEX:980] xref: BIRNLEX:980 xref: SCTID:362441000 xref: UMLS:C0228627 {source="BIRNLEX:980"} is_a: UBERON:0002315 ! gray matter of spinal cord intersection_of: UBERON:0002315 ! gray matter of spinal cord intersection_of: BFO:0000050 UBERON:0003038 ! part of thoracic spinal cord relationship: BFO:0000050 UBERON:0003038 ! part of thoracic spinal cord property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "thoracic spinal cord gray matter" xsd:string [Term] id: UBERON:0014637 name: thoracic spinal cord white matter def: "A white matter of spinal cord that is part of a thoracic spinal cord." [OBOL:automatic] subset: human_reference_atlas synonym: "thoracic spinal cord white matter" EXACT HUMAN_PREFERRED [BIRNLEX:999] xref: BIRNLEX:999 xref: SCTID:367881009 xref: UMLS:C0228633 {source="BIRNLEX:999"} xref: UMLS:C1288557 {source="BIRNLEX:999"} is_a: UBERON:0002318 ! white matter of spinal cord intersection_of: UBERON:0002318 ! white matter of spinal cord intersection_of: BFO:0000050 UBERON:0003038 ! part of thoracic spinal cord relationship: BFO:0000050 UBERON:0003038 ! part of thoracic spinal cord property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "thoracic spinal cord white matter" xsd:string [Term] id: UBERON:0014638 name: lumbar spinal cord dorsal horn def: "A dorsal horn of spinal cord that is part of a lumbar spinal cord." [OBOL:automatic] subset: human_reference_atlas synonym: "lumbar spinal cord dorsal horn" EXACT HUMAN_PREFERRED [BIRNLEX:884] synonym: "lumbar spinal cord posterior horn" RELATED [BIRNLEX:884] xref: BIRNLEX:884 xref: UMLS:C1282146 {source="BIRNLEX:884"} is_a: UBERON:0002256 ! dorsal horn of spinal cord intersection_of: UBERON:0002256 ! dorsal horn of spinal cord intersection_of: BFO:0000050 UBERON:0002792 ! part of lumbar spinal cord relationship: BFO:0000050 UBERON:0002792 ! part of lumbar spinal cord property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0014639 name: frontal sulcus def: "A sulcus of brain that is part of a frontal cortex." [OBOL:automatic] synonym: "frontal lobe sulci" EXACT OMO:0003004 [HBA:FLs] synonym: "frontal lobe sulcus" EXACT [] xref: HBA:9354 xref: NCIT:C32639 xref: UMLS:C0459388 {source="ncithesaurus:Frontal_Sulcus"} is_a: UBERON:0013118 ! sulcus of brain intersection_of: UBERON:0013118 ! sulcus of brain intersection_of: BFO:0000050 UBERON:0001870 ! part of frontal cortex relationship: BFO:0000050 UBERON:0001870 ! part of frontal cortex property_value: skos:prefLabel "frontal sulcus" xsd:string [Term] id: UBERON:0014642 name: vestibulocerebellum def: "A phylogenetic subdivision of the cerebellum, the oldest part, which regulates balance and eye movements. It receives vestibular input from both the semicircular canals and from the vestibular nuclei, and sends fibres back to the medial and lateral vestibular nuclei. It also receives visual input from the superior colliculi and from the visual cortex (the latter via the pontine nuclei, forming a cortico-ponto-cerebellar pathway). Lesions of the vestibulocerebellum cause disturbances of balance and gait." [Wikipedia:Anatomy_of_the_cerebellum#Phylogenetic_and_functional_divisions] synonym: "archaeocerebellum" RELATED [BIRNLEX:904] synonym: "archeocerebellum" RELATED [BIRNLEX:904] synonym: "archicerebellum" EXACT [] synonym: "archicerebellum" RELATED [BIRNLEX:904] is_a: UBERON:0002616 ! regional part of brain relationship: BFO:0000050 UBERON:0002037 ! part of cerebellum property_value: skos:prefLabel "vestibulocerebellum" xsd:string [Term] id: UBERON:0014649 name: white matter of medulla oblongata def: "A white matter that is part of a medulla oblongata." [OBOL:automatic] synonym: "medullary white matter" RELATED [BAMS:mw] synonym: "substantia alba medullae oblongatae" EXACT [FMA:TA] synonym: "white matter of medulla" EXACT [FMA:83944] synonym: "white substance of medulla" EXACT [FMA:83944] xref: BAMS:mw xref: BIRNLEX:1024 xref: BIRNLEX:1414 xref: FMA:83944 xref: neuronames:778 is_a: UBERON:0014891 ! brainstem white matter is_a: UBERON:0019262 ! white matter of myelencephalon intersection_of: UBERON:0002316 ! white matter intersection_of: BFO:0000050 UBERON:0001896 ! part of medulla oblongata relationship: BFO:0000050 UBERON:0001896 ! part of medulla oblongata property_value: skos:prefLabel "white matter of medulla oblongata" xsd:string [Term] id: UBERON:0014686 name: angular vein def: "The angular vein formed by the junction of the frontal vein and supraorbital vein, runs obliquely downward, on the side of the root of the nose, to the level of the lower margin of the orbit, where it becomes the anterior facial vein. It receives the external nasal veins of the ala nasi, and communicates with the superior ophthalmic vein through the nasofrontal vein, thus establishing an important anastomosis between the anterior facial vein and the cavernous sinus." [Wikipedia:Angular_vein] subset: human_reference_atlas xref: FMA:50893 xref: SCTID:151804007 xref: Wikipedia:Angular_vein is_a: UBERON:0003496 ! head blood vessel is_a: UBERON:0009141 ! craniocervical region vein relationship: RO:0002376 UBERON:0001653 ! tributary of facial vein property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0014687 name: temporal sulcus def: "Any of three grooves in the temporal lobe including the inferior, middle, and superior temporal sulci." [ncithesaurus:Temporal_Sulcus] synonym: "temporal lobe sulci" EXACT OMO:0003004 [HBA:TLs] synonym: "temporal lobe sulcus" EXACT [] xref: HBA:9377 xref: NCIT:C33744 xref: UMLS:C0459389 is_a: UBERON:0013118 ! sulcus of brain intersection_of: UBERON:0013118 ! sulcus of brain intersection_of: BFO:0000050 UBERON:0001871 ! part of temporal lobe relationship: BFO:0000050 UBERON:0001871 ! part of temporal lobe property_value: skos:prefLabel "temporal sulcus" xsd:string [Term] id: UBERON:0014695 name: deep auricular artery def: "The deep auricular artery often arises in common with the anterior tympanic artery. It ascends in the substance of the parotid gland, behind the temporomandibular articulation, pierces the cartilaginous or bony wall of the external acoustic meatus, and supplies its cuticular lining and the outer surface of the tympanic membrane. It gives a branch to the temporomandibular joint." [Wikipedia:Deep_auricular_artery] subset: human_reference_atlas xref: FMA:49689 xref: SCTID:147157007 xref: Wikipedia:Deep_auricular_artery is_a: UBERON:0009655 ! auricular artery intersection_of: UBERON:0009655 ! auricular artery intersection_of: BFO:0000050 UBERON:0035551 ! part of deep vasculature relationship: BFO:0000050 UBERON:0035551 ! part of deep vasculature relationship: RO:0002252 UBERON:0001616 {source="FMA"} ! connecting branch of maxillary artery relationship: RO:0020101 UBERON:0010069 ! vessel supplies blood to outer epithelial layer of tympanic membrane property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0014699 name: extraembryonic venous system def: "A venous system that overlaps a umbilical cord and is part of a entire extraembryonic component." [OBOL:automatic] xref: EHDAA2:0000479 xref: EMAPA:16374 xref: VHOG:0000282 is_a: UBERON:0004582 ! venous system is_a: UBERON:0014701 {source="VHOG"} ! extraembryonic vascular system intersection_of: UBERON:0004582 ! venous system intersection_of: BFO:0000050 UBERON:0016887 ! part of entire extraembryonic component intersection_of: RO:0002131 UBERON:0002331 ! overlaps umbilical cord [Term] id: UBERON:0014701 name: extraembryonic vascular system def: "A vascular system that overlaps a umbilical cord and is part of a entire extraembryonic component." [OBOL:automatic] xref: EHDAA2:0000478 xref: EMAPA:16370 xref: VHOG:0001396 is_a: UBERON:0007798 ! vascular system intersection_of: UBERON:0007798 ! vascular system intersection_of: BFO:0000050 UBERON:0016887 ! part of entire extraembryonic component intersection_of: RO:0002131 UBERON:0002331 ! overlaps umbilical cord relationship: BFO:0000050 UBERON:0016887 ! part of entire extraembryonic component relationship: RO:0002131 UBERON:0002331 ! overlaps umbilical cord [Term] id: UBERON:0014702 name: frontonasal process epithelium def: "An epithelium that is part of a frontonasal prominence." [OBOL:automatic] xref: EHDAA2:0004108 xref: EMAPA:32918 is_a: BFO:0000002 is_a: UBERON:0000490 {source="EHDAA2"} ! unilaminar epithelium is_a: UBERON:0005291 ! embryonic tissue intersection_of: UBERON:0000483 ! epithelium intersection_of: BFO:0000050 UBERON:0004066 ! part of frontonasal prominence relationship: BFO:0000050 UBERON:0004066 ! part of frontonasal prominence relationship: RO:0002202 UBERON:0000076 {source="EHDAA2"} ! develops from external ectoderm property_value: skos:prefLabel "frontonasal process epithelium" xsd:string [Term] id: UBERON:0014703 name: anal membrane ectodermal component def: "A unilaminar epithelium that develops_from a ectoderm and is part of a anal region." [OBOL:automatic] xref: EHDAA2:0004019 xref: EMAPA:25040 is_a: UBERON:0000490 ! unilaminar epithelium is_a: UBERON:0010371 ! ecto-epithelium intersection_of: UBERON:0000490 ! unilaminar epithelium intersection_of: BFO:0000050 UBERON:0001353 ! part of anal region intersection_of: RO:0002202 UBERON:0000924 ! develops from ectoderm relationship: BFO:0000050 UBERON:0001353 ! part of anal region property_value: skos:prefLabel "anal membrane ectodermal component" xsd:string [Term] id: UBERON:0014704 name: pleuroperitoneal canal lumen def: "An anatomical space that is enclosed by a pleuroperitoneal canal." [OBOL:automatic] synonym: "pleuro-peritoneal canal cavity" EXACT [EMAPA:25034] xref: EHDAA2:0004736 xref: EMAPA:25034 is_a: BFO:0000002 is_a: UBERON:0000464 ! anatomical space intersection_of: UBERON:0000464 ! anatomical space intersection_of: RO:0002572 UBERON:0006279 ! luminal space of pleuroperitoneal canal relationship: RO:0002202 UBERON:0002323 {source="EHDAA2"} ! develops from coelemic cavity lumen relationship: RO:0002572 UBERON:0006279 ! luminal space of pleuroperitoneal canal property_value: skos:prefLabel "pleuroperitoneal canal lumen" xsd:string [Term] id: UBERON:0014705 name: median lingual swelling epithelium def: "An epithelium that is part of a median lingual swelling." [OBOL:automatic] synonym: "tuberculum impar epitheilium" RELATED [EMAPA:17188] xref: EHDAA2:0001085 xref: EMAPA:17188 is_a: UBERON:0000490 {source="EHDAA2"} ! unilaminar epithelium is_a: UBERON:0003929 ! digestive tract epithelium is_a: UBERON:0005291 ! embryonic tissue is_a: UBERON:0005911 ! endo-epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: BFO:0000050 UBERON:0006756 ! part of median lingual swelling relationship: BFO:0000050 UBERON:0006756 ! part of median lingual swelling relationship: RO:0002202 UBERON:0013156 {source="EHDAA2"} ! develops from 1st arch mandibular endoderm property_value: skos:prefLabel "median lingual swelling epithelium" xsd:string [Term] id: UBERON:0014706 name: primitive renal collecting duct system synonym: "metanephros primitive collecting ducts" EXACT [EHDAA2:0001147] synonym: "primitive collecting duct" EXACT [EMAPA:17646] xref: EHDAA2:0001147 xref: EMAPA:17646 is_a: UBERON:0007501 {source="EHDAA2"} ! arborizing epithelial duct system is_a: UBERON:0012275 ! meso-epithelium relationship: RO:0002202 UBERON:0000084 {source="EHDAA2"} ! develops from ureteric bud [Term] id: UBERON:0014716 name: interlobular duct def: "A duct that is located between lobules, within the thin connective tissue septa that separate lobules. All interlobular ducts are excretory." [ncithesaurus:Interlobular_Duct] subset: human_reference_atlas xref: NCIT:C32828 xref: UMLS:C1512857 xref: Wikipedia:Interlobular_ducts is_a: UBERON:0035050 ! excretory duct intersection_of: UBERON:0000058 ! duct intersection_of: BFO:0000050 UBERON:0002384 ! part of connective tissue intersection_of: RO:0002170 UBERON:0009911 ! connected to lobule relationship: BFO:0000050 UBERON:0002384 ! part of connective tissue relationship: RO:0002170 UBERON:0009911 ! connected to lobule property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "interlobular duct" xsd:string [Term] id: UBERON:0014717 name: mucous acinus def: "The secretory unit of a mucous gland. The acinar portion is composed of mucous secreting cells." [http://orcid.org/0000-0002-6601-2165, http://www.siumed.edu/~dking2/intro/glands.htm] synonym: "acinus of mucuous gland" EXACT [] synonym: "mucus acinus" EXACT [] xref: FMA:86278 is_a: UBERON:0011858 ! acinus of exocrine gland intersection_of: UBERON:0009842 ! glandular acinus intersection_of: BFO:0000050 UBERON:0000414 ! part of mucous gland relationship: BFO:0000050 UBERON:0000414 ! part of mucous gland relationship: RO:0002473 CL:0000319 ! composed primarily of mucus secreting cell property_value: skos:prefLabel "mucous acinus" xsd:string [Term] id: UBERON:0014719 name: intralobular duct def: "A duct that is located within a lobule, with no more connective tissue intervening between ducts and secretory units (i.e., acini or tubules) than between adjacent secretory units. Intercalated and striated ducts are intralobular." [http://www.siumed.edu/~dking2/intro/glands.htm] subset: human_reference_atlas synonym: "intralobular ductule" RELATED [] xref: SCTID:205214009 is_a: UBERON:0000058 ! duct intersection_of: UBERON:0000058 ! duct intersection_of: BFO:0000050 UBERON:0009911 ! part of lobule relationship: BFO:0000050 UBERON:0009911 ! part of lobule property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "intralobular duct" xsd:string [Term] id: UBERON:0014720 name: interlobar duct def: "A duct that is located between lobes, within conspicuous, thick connective tissue septa that separate lobes. All interlobar ducts are excretory." [http://www.siumed.edu/~dking2/intro/glands.htm] synonym: "intralobular ductule" RELATED [] is_a: UBERON:0035050 ! excretory duct intersection_of: UBERON:0000058 ! duct intersection_of: BFO:0000050 UBERON:0002384 ! part of connective tissue intersection_of: RO:0002176 UBERON:0009912 ! connects anatomical lobe relationship: BFO:0000050 UBERON:0002384 ! part of connective tissue relationship: RO:0002176 UBERON:0009912 ! connects anatomical lobe property_value: skos:prefLabel "interlobar duct" xsd:string [Term] id: UBERON:0014725 name: intercalated duct def: "A small duct which drains individual secretory units. These are usually inconspicuous, lined by a simple epithelium consisting of low cuboidal cells." [http://www.siumed.edu/~dking2/intro/glands.htm] synonym: "secretory duct" RELATED [] xref: NCIT:C32820 xref: UMLS:C1512817 is_a: UBERON:0014719 ! intralobular duct [Term] id: UBERON:0014726 name: intercalated duct of pancreas def: "An intercalated duct that is part of a pancreas." [OBOL:automatic] subset: human_reference_atlas synonym: "ductus intercalatus (pancreas)" EXACT [FMA:16013] synonym: "pancreatic ductule" EXACT [FMA:16013] xref: FMA:16013 xref: NCIT:C49267 xref: SCTID:247520007 is_a: UBERON:0014725 ! intercalated duct intersection_of: UBERON:0014725 ! intercalated duct intersection_of: BFO:0000050 UBERON:0001264 ! part of pancreas relationship: BFO:0000050 UBERON:0001264 ! part of pancreas property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0014727 name: intercalated duct of salivary gland def: "The tiny tubules with a very thin epithelial layer in the salivary glands running from the salivary acini into the striated duct." [ncithesaurus:Intercalated_Duct_of_the_Salivary_Gland_System] xref: FMA:60050 xref: NCIT:C49266 is_a: UBERON:0001837 ! duct of salivary gland is_a: UBERON:0014725 ! intercalated duct intersection_of: UBERON:0014725 ! intercalated duct intersection_of: BFO:0000050 UBERON:0001044 ! part of saliva-secreting gland [Term] id: UBERON:0014729 name: striated duct of salivary gland def: "Gland duct which connects an intercalated duct to an interlobular duct in a salivary gland." [http://orcid.org/0000-0002-6601-2165, Wikipedia:Striated_duct] xref: FMA:60051 xref: NCIT:C33635 xref: UMLS:C1514993 is_a: UBERON:0001837 ! duct of salivary gland is_a: UBERON:0014719 ! intralobular duct intersection_of: UBERON:0001837 ! duct of salivary gland intersection_of: RO:0002176 UBERON:0014720 ! connects interlobar duct intersection_of: RO:0002176 UBERON:0014727 ! connects intercalated duct of salivary gland relationship: RO:0002176 UBERON:0014720 ! connects interlobar duct relationship: RO:0002176 UBERON:0014727 ! connects intercalated duct of salivary gland [Term] id: UBERON:0014734 name: allocortex def: "One of two types of cerebral cortex defined on the basis of cytoarchitecture and fetal development. The other is neocortex. Allocortex does not pass through a prenatal phase of six-layered structure and has three or four layers in the mature brain ( Schiebler-1999 ). Allocortex has three subtypes: paleocortex, archicortex and periallocortex. This definition differs from that in some older sources, which excluded the olfactory bulb and the accessory olfactory bulb ( Carpenter-1983 )." [NeuroNames:759] comment: The allocortex is composed of hippocampal and olfactory structures, which usually display three-layered organization[Brainspan] synonym: "allocortex (Stephan)" RELATED [NeuroNames:1598] synonym: "heterogenetic cortex" RELATED [NeuroNames:1598] synonym: "heterogenetic formations" RELATED [NeuroNames:1598] synonym: "intercalated nucleus of the medulla" RELATED [NeuroNames:759] synonym: "nucleus intercalatus (staderini)" RELATED OMO:0003011 [NeuroNames:759] synonym: "transitional cortex" RELATED [ISBN:0471888893] xref: BAMS:All xref: DHBA:10292 xref: FMA:83687 xref: neuronames:759 xref: NLX:143557 xref: Wikipedia:Allocortex is_a: UBERON:0002616 ! regional part of brain relationship: BFO:0000050 UBERON:0000956 ! part of cerebral cortex property_value: skos:prefLabel "allocortex" xsd:string [Term] id: UBERON:0014735 name: paleocortex def: "Part of the allocortex defined on the basis of cytoarchitecture. The other two are archicortex and periallocortex. It consists of very thin, primitive cortex with few clearly defined layers. It is distinguished ontogenetically by the fact that it does not develop through a cortical plate. It includes the olfactory bulb, accessory olfactory bulb, olfactory tubercle, septum, prepyriform area and periamygdalar area ( Stephan-1975 ). (adapted from Brain Info)." [NLX:143559] synonym: "palaeocortex" EXACT OMO:0003011 [FMA:62430, FMA:TA] synonym: "paleocortex" RELATED [NeuroNames:2336] synonym: "paleocortex (semicortex)" EXACT [DHBA:10306] synonym: "paleocortex (Zilles)" RELATED [NeuroNames:2336] xref: BAMS:Paleocortex xref: DHBA:10306 xref: FMA:62430 xref: neuronames:2336 xref: NLX:143559 xref: Wikipedia:Paleocortex is_a: UBERON:0014734 {source="FMA"} ! allocortex property_value: skos:prefLabel "paleocortex" xsd:string [Term] id: UBERON:0014769 name: palpebral vein def: "A blood vessel that drains from from an eyelid." [http://orcid.org/0000-0002-6601-2165] synonym: "palpebral veins" RELATED OMO:0003004 [] synonym: "venae palpebrales" RELATED OMO:0003011 [] xref: FMA:51997 xref: SCTID:152208004 is_a: UBERON:0003496 ! head blood vessel is_a: UBERON:0009141 ! craniocervical region vein intersection_of: UBERON:0001638 ! vein intersection_of: RO:0020102 UBERON:0001711 ! vessel drains blood from eyelid relationship: RO:0002376 UBERON:0014686 ! tributary of angular vein relationship: RO:0020102 UBERON:0001711 ! vessel drains blood from eyelid [Term] id: UBERON:0014770 name: palpebral artery def: "An artery that supplies blood to an eyelid." [http://orcid.org/0000-0002-6601-2165] xref: SCTID:148571007 is_a: UBERON:0001637 ! artery is_a: UBERON:0003496 ! head blood vessel intersection_of: UBERON:0001637 ! artery intersection_of: RO:0020101 UBERON:0001711 ! vessel supplies blood to eyelid relationship: RO:0020101 UBERON:0001711 ! vessel supplies blood to eyelid [Term] id: UBERON:0014775 name: prosomere def: "A neuromere that is part of the presumptive forebrain." [http://orcid.org/0000-0002-6601-2165] synonym: "forebrain neuromere" EXACT [] synonym: "forebrain segment" BROAD [] synonym: "future prosencephalon" RELATED [] synonym: "segment of forebrain" BROAD [] xref: FMA:61996 is_a: UBERON:0004731 ! neuromere intersection_of: UBERON:0004731 ! neuromere intersection_of: BFO:0000050 UBERON:0006240 ! part of future forebrain relationship: BFO:0000050 UBERON:0006240 ! part of future forebrain property_value: skos:prefLabel "prosomere" xsd:string [Term] id: UBERON:0014776 name: midbrain neuromere def: "A neuromere that is part of the presumptive midbrain." [http://orcid.org/0000-0002-6601-2165] synonym: "future mesencephalon" RELATED [] synonym: "mesomere" BROAD [] synonym: "mesomere group" RELATED [EHDAA2:0004352] synonym: "mesomere of nervous system" EXACT [] synonym: "midbrain segment" BROAD [] synonym: "neuromere of mesomere group" EXACT [] synonym: "segment of midbrain" BROAD [] xref: EHDAA2:0004352 xref: FMA:61997 is_a: UBERON:0004731 ! neuromere intersection_of: UBERON:0004731 ! neuromere intersection_of: BFO:0000050 UBERON:0009616 ! part of presumptive midbrain relationship: BFO:0000050 UBERON:0009616 ! part of presumptive midbrain property_value: skos:prefLabel "midbrain neuromere" xsd:string [Term] id: UBERON:0014777 name: spinal neuromere def: "A neuromere that is part of the presumptive spinal cord." [http://orcid.org/0000-0002-6601-2165] synonym: "spinal cord metameric segment" EXACT [] synonym: "spinal cord segment" RELATED [TAO:0001332] synonym: "spinal neuromeres" EXACT OMO:0003004 [TAO:0001332] xref: TAO:0001332 xref: ZFA:0001332 is_a: UBERON:0004731 ! neuromere intersection_of: UBERON:0004731 ! neuromere intersection_of: BFO:0000050 UBERON:0006241 ! part of future spinal cord relationship: BFO:0000050 UBERON:0006241 ! part of future spinal cord property_value: skos:prefLabel "spinal neuromere" xsd:string [Term] id: UBERON:0014783 name: cloacal muscle def: "Any muscle organ that is part of a cloaca." [OBOL:automatic] is_a: UBERON:0001630 ! muscle organ is_a: UBERON:0013765 ! digestive system element intersection_of: UBERON:0001630 ! muscle organ intersection_of: BFO:0000050 UBERON:0000162 ! part of cloaca relationship: BFO:0000050 UBERON:0000162 ! part of cloaca property_value: skos:prefLabel "cloacal muscle" xsd:string [Term] id: UBERON:0014790 name: lingual septum def: "The lingual septum consists of a vertical layer of fibrous tissue, extending throughout the entire length of the median plane of the tongue, though not quite reaching the dorsum. It is thicker behind than in front, and occasionally contains a small fibrocartilage, about 6 mm. in length. It is well displayed by making a vertical section across the organ." [Wikipedia:Lingual_septum] subset: human_reference_atlas synonym: "median fibrous septum" RELATED [Wikipedia:Lingual_septum] synonym: "septum of tongue" EXACT [FMA:54813] synonym: "septum of tongue" RELATED [Wikipedia:Lingual_septum] synonym: "tongue septum" RELATED [Wikipedia:Lingual_septum] xref: EMAPA:18274 xref: FMA:54813 xref: SCTID:368727001 xref: Wikipedia:Lingual_septum is_a: UBERON:0003037 ! septum intersection_of: UBERON:0003037 ! septum intersection_of: BFO:0000050 UBERON:0001723 ! part of tongue relationship: BFO:0000050 UBERON:0001723 ! part of tongue property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "lingual septum" xsd:string [Term] id: UBERON:0014791 name: musculature of forelimb stylopod def: "Any collection of muscles that is part of the forelimb stylopod region [Automatically generated definition]." [OBOL:automatic] synonym: "arm musculature" RELATED INCONSISTENT [FMA:50202] synonym: "muscle group of arm" RELATED INCONSISTENT [FMA:50202] synonym: "musculature of arm" RELATED INCONSISTENT [FMA:50202] synonym: "set of muscles of arm" RELATED INCONSISTENT [FMA:50202] xref: FMA:50202 is_a: UBERON:0004474 ! musculature of arm intersection_of: UBERON:0001015 ! musculature intersection_of: BFO:0000050 UBERON:0003822 ! part of forelimb stylopod relationship: BFO:0000050 UBERON:0003822 ! part of forelimb stylopod [Term] id: UBERON:0014792 name: musculature of pelvic complex def: "Any collection of muscles that is part of a pelvic complex. The pelvic complex comprises the pelvic girdle and the associated limb or fin." [OBOL:automatic] synonym: "muscles of lower limb" NARROW [FMA:71297] synonym: "musculature of lower limb" NARROW [FMA:71297] synonym: "musculi membri inferioris" NARROW [FMA:TA] xref: EMAPA:37864 {source="MA:th"} xref: FMA:71297 is_a: UBERON:0001015 ! musculature intersection_of: UBERON:0001015 ! musculature intersection_of: BFO:0000050 UBERON:0010709 ! part of pelvic complex relationship: BFO:0000050 UBERON:0010709 ! part of pelvic complex property_value: IAO:0000116 "currently defined by location rather than attachment" xsd:string [Term] id: UBERON:0014793 name: musculature of pectoral complex def: "Any collection of muscles that is part of a pectoral complex. The pectoral complex comprises the pectoral girdle and the associated limb or fin." [OBOL:automatic] synonym: "muscles of upper limb" NARROW [FMA:71296] synonym: "musculature of upper limb" NARROW [FMA:71296] synonym: "musculi membri superioris" NARROW [FMA:TA] synonym: "set of muscles of upper limb" NARROW [FMA:71296] synonym: "upper limb musculature" NARROW [FMA:71296] xref: EMAPA:37861 {source="MA:th"} xref: FMA:71296 is_a: UBERON:0001015 ! musculature intersection_of: UBERON:0001015 ! musculature intersection_of: BFO:0000050 UBERON:0010708 ! part of pectoral complex relationship: BFO:0000050 UBERON:0010708 ! part of pectoral complex property_value: IAO:0000116 "currently defined by location rather than attachment" xsd:string property_value: skos:prefLabel "musculature of pectoral complex" xsd:string [Term] id: UBERON:0014794 name: pectoral appendage muscle def: "Any muscle organ that is part of a pectoral appendage (forelimb or pectoral fin)." [OBOL:automatic] is_a: UBERON:0010891 ! pectoral complex muscle intersection_of: UBERON:0014892 ! skeletal muscle organ, vertebrate intersection_of: BFO:0000050 UBERON:0004710 ! part of pectoral appendage relationship: BFO:0000050 UBERON:0007269 {source="prolog"} ! part of pectoral appendage musculature property_value: skos:prefLabel "pectoral appendage muscle" xsd:string [Term] id: UBERON:0014795 name: pelvic appendage muscle def: "Any muscle organ that is part of a pelvic appendage (hindlimb or pelvic fin)." [OBOL:automatic] is_a: UBERON:0010890 ! pelvic complex muscle intersection_of: UBERON:0014892 ! skeletal muscle organ, vertebrate intersection_of: BFO:0000050 UBERON:0004709 ! part of pelvic appendage relationship: BFO:0000050 UBERON:0007270 {source="prolog"} ! part of pelvic appendage musculature [Term] id: UBERON:0014889 name: left hemisphere of cerebellum def: "A cerebellar hemisphere that is in_the_left_side_of a cerebellum." [OBOL:automatic] subset: pheno_slim xref: FMA:83877 is_a: UBERON:0002245 ! cerebellar hemisphere intersection_of: UBERON:0002245 ! cerebellar hemisphere intersection_of: BSPO:0000120 UBERON:0002037 ! cerebellum relationship: BSPO:0000120 UBERON:0002037 ! cerebellum property_value: skos:prefLabel "left hemisphere of cerebellum" xsd:string [Term] id: UBERON:0014890 name: right hemisphere of cerebellum def: "A cerebellar hemisphere that is in_the_right_side_of a cerebellum." [OBOL:automatic] subset: pheno_slim xref: FMA:83876 is_a: UBERON:0002245 ! cerebellar hemisphere intersection_of: UBERON:0002245 ! cerebellar hemisphere intersection_of: BSPO:0000121 UBERON:0002037 ! cerebellum relationship: BSPO:0000121 UBERON:0002037 ! cerebellum property_value: skos:prefLabel "right hemisphere of cerebellum" xsd:string [Term] id: UBERON:0014891 name: brainstem white matter def: "White matter that is part of a brainstem [Automatically generated definition]." [OBOL:automatic] subset: pheno_slim synonym: "brain stem white matter" RELATED [EMAPA:35189] synonym: "brainstem tract/commissure" RELATED [] synonym: "brainstem tracts" RELATED [] synonym: "brainstem tracts and commissures" RELATED [] xref: EMAPA:35189 xref: FMA:282112 xref: MA:0002741 xref: SCTID:360442003 is_a: UBERON:0003544 ! brain white matter intersection_of: UBERON:0002316 ! white matter intersection_of: BFO:0000050 UBERON:0002298 ! part of brainstem relationship: BFO:0000050 UBERON:0002298 ! part of brainstem property_value: skos:prefLabel "brainstem white matter" xsd:string [Term] id: UBERON:0014892 name: skeletal muscle organ, vertebrate def: "A muscle organ that consists of skeletal muscle tissue ensheathed in epimysium, that develops from myotome and that is innervated by some somatic motor neuron. Skeletal muscles are typically attached (via a tendon) to a bone but there are exceptions (e.g. intrinsic tongue muscles)." [GOC:dos] subset: human_reference_atlas synonym: "skeletal muscle" BROAD [] xref: AAO:0011099 xref: BTO:0001103 xref: CALOHA:TS-0933 xref: EFO:0000888 xref: EHDAA:5035 xref: EHDAA:5043 xref: EHDAA:5978 xref: EHDAA:5984 xref: EMAPA:35988 xref: EV:0100377 xref: GAID:141 xref: MA:0003148 xref: MAT:0000302 xref: MESH:D018482 xref: MIAA:0000302 xref: TAO:0005277 xref: VHOG:0000319 xref: XAO:0000174 xref: ZFA:0005277 is_a: UBERON:0001630 ! muscle organ intersection_of: UBERON:0001630 ! muscle organ intersection_of: RO:0002103 CL:0000100 ! synapsed by motor neuron intersection_of: RO:0002202 UBERON:0003082 ! develops from myotome intersection_of: RO:0002219 UBERON:0011899 ! surrounded by epimysium intersection_of: RO:0002473 UBERON:0001134 ! composed primarily of skeletal muscle tissue relationship: BFO:0000050 UBERON:0018254 ! part of skeletal musculature relationship: RO:0002103 CL:0000100 ! synapsed by motor neuron relationship: RO:0002202 UBERON:0003082 ! develops from myotome relationship: RO:0002219 UBERON:0011899 ! surrounded by epimysium relationship: RO:0002473 UBERON:0001134 ! composed primarily of skeletal muscle tissue property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "skeletal muscle organ, vertebrate" xsd:string [Term] id: UBERON:0014903 name: primordial vasculature def: "A portion of tissue that will develop into vasculature." [ZFA:0005076, ZFA:curator] xref: EFO:0003708 xref: TAO:0005076 xref: ZFA:0005076 is_a: UBERON:0001048 ! primordium intersection_of: UBERON:0001048 ! primordium intersection_of: RO:0002387 UBERON:0002049 ! has potential to develop into vasculature relationship: BFO:0000050 UBERON:0011695 ! part of embryonic cardiovascular system relationship: RO:0002387 UBERON:0002049 ! has potential to develop into vasculature property_value: skos:prefLabel "primordial vasculature" xsd:string [Term] id: UBERON:0014907 name: intersomitic vessel def: "One of the primary blood vessel sprouts that originate from the dorsal aorta and posterior cardinal vein and align dorsoventrally at the myotomal boundaries between somites." [MGI:anna] subset: pheno_slim synonym: "intersegmental vessel" EXACT [ZFA:0001285] synonym: "intersegmental vessels" EXACT OMO:0003004 [ZFA:0001285] synonym: "intersomitic blood vessel" EXACT [XAO:0004075] synonym: "intersomitic vessels" EXACT OMO:0003004 [ZFA:0001285] synonym: "segmental vessel" EXACT [ZFA:0001285] xref: EFO:0003664 xref: EMAPA:37389 {source="MA:th"} xref: TAO:0001285 xref: XAO:0004075 xref: ZFA:0001285 is_a: UBERON:0001981 {source="ZFA"} ! blood vessel is_a: UBERON:0004120 ! mesoderm-derived structure relationship: RO:0002202 UBERON:0005805 {source="ZFA"} ! develops from dorsal aorta property_value: skos:prefLabel "intersomitic vessel" xsd:string [Term] id: UBERON:0014930 name: perivascular space def: "The space between a blood vessel and the pia mater." [DOI:10.1007/s11064-015-1581-6, ncithesaurus:Perivascular_Space] comment: VRS belonging to the subarachnoid space are continuous with VRS of the subpial space. The direct communication between VRS of the subarachnoid space and the subpial space is unique to the brain's arteries, as no leptomeningeal layers surround the brain's veins[WP] subset: pheno_slim synonym: "perivascular region" EXACT [] synonym: "perivascular spaces" RELATED OMO:0003004 [] synonym: "Virchow-Robin space" EXACT [Wikipedia:Virchow-Robin_space] synonym: "VRS" BROAD OMO:0003000 [Wikipedia:Virchow-Robin_space] xref: NCIT:C83196 xref: SCTID:342298001 xref: UMLS:C0225983 xref: Wikipedia:Virchow-Robin_space is_a: UBERON:0000464 ! anatomical space intersection_of: UBERON:0000464 ! anatomical space intersection_of: RO:0002220 UBERON:0001981 ! adjacent to blood vessel intersection_of: RO:0002220 UBERON:0002361 ! adjacent to pia mater relationship: BFO:0000050 UBERON:0010743 ! part of meningeal cluster relationship: RO:0001015 UBERON:0001359 ! location of cerebrospinal fluid relationship: RO:0002220 UBERON:0001981 ! adjacent to blood vessel relationship: RO:0002220 UBERON:0002361 ! adjacent to pia mater property_value: foaf:depiction "https://static-content.springer.com/image/art%3A10.1007%2Fs11064-015-1581-6/MediaObjects/11064_2015_1581_Fig3_HTML.gif" xsd:anyURI property_value: skos:prefLabel "perivascular space" xsd:string [Term] id: UBERON:0014935 name: cerebral cortex marginal layer def: "Developing superficial cortical layer located just under the pia matter, develops from the marginal layer of the neural tube and becomes cortical layer I." [http://orcid.org/0000-0002-6601-2165, MP:0000792] synonym: "cerebral cortex marginal zone" RELATED [EMAPA:32713] synonym: "cortical marginal layer" EXACT [http://orcid.org/0000-0002-6601-2165] synonym: "cortical marginal zone" EXACT [MP:0000792] synonym: "future cortical layer I" EXACT [http://orcid.org/0000-0002-6601-2165] synonym: "marginal zone" BROAD [PBA:294021774] synonym: "MZ" BROAD OMO:0003000 [BRAINSPAN:BRAINSPAN, MP:0000792] xref: EMAPA:17546 xref: EMAPA:32713 xref: PBA:294021774 is_a: BFO:0000002 is_a: UBERON:0014950 ! layer of developing cerebral cortex relationship: BFO:0000050 UBERON:0010403 ! part of brain marginal zone relationship: RO:0002202 UBERON:0004062 ! develops from neural tube marginal layer property_value: skos:prefLabel "cerebral cortex marginal layer" xsd:string [Term] id: UBERON:0014950 name: layer of developing cerebral cortex is_a: UBERON:0005423 ! developing anatomical structure relationship: BFO:0000050 UBERON:0000956 {source="EMAPA"} ! part of cerebral cortex property_value: skos:prefLabel "layer of developing cerebral cortex" xsd:string [Term] id: UBERON:0015004 name: tibia endochondral element def: "The major preaxial endochondral element in the posterior zeugopod[Phenoscape]." [https://github.com/obophenotype/uberon/issues/71, PHENOSCAPE:mah] synonym: "tibia element" EXACT [https://github.com/obophenotype/uberon/wiki/Modeling-endochondral-elements-Design-Pattern] synonym: "tibia skeletal element" BROAD [https://github.com/obophenotype/uberon/wiki/Modeling-endochondral-elements-Design-Pattern] is_a: UBERON:0015022 ! hindlimb endochondral element union_of: UBERON:0000979 ! tibia union_of: UBERON:0010849 ! tibia cartilage element union_of: UBERON:0010850 ! tibia pre-cartilage condensation relationship: BFO:0000050 UBERON:0010720 ! part of hindlimb zeugopod skeleton property_value: terms:contributor https://orcid.org/0000-0001-9114-8737 property_value: terms:contributor https://orcid.org/0000-0002-6601-2165 [Term] id: UBERON:0015007 name: cervical vertebra endochondral element def: "A vertebral endochondral element in the cervical region of the vertebral column." [http://orcid.org/0000-0002-6601-2165] synonym: "cervical vertebra element" EXACT [https://github.com/obophenotype/uberon/wiki/Modeling-endochondral-elements-Design-Pattern] synonym: "cervical vertebra skeletal element" BROAD [https://github.com/obophenotype/uberon/wiki/Modeling-endochondral-elements-Design-Pattern] is_a: UBERON:0005174 ! dorsal region element is_a: UBERON:0010913 ! vertebral element intersection_of: UBERON:0010913 ! vertebral element intersection_of: BFO:0000050 UBERON:0006072 ! part of cervical region of vertebral column union_of: UBERON:0002413 ! cervical vertebra union_of: UBERON:0013505 ! cervical vertebra cartilage element union_of: UBERON:0013506 ! cervical vertebra pre-cartilage condensation relationship: BFO:0000050 UBERON:0006072 ! part of cervical region of vertebral column property_value: skos:prefLabel "cervical vertebra endochondral element" xsd:string [Term] id: UBERON:0015008 name: thoracic vertebra endochondral element def: "A vertebral endochondral element in the thoracic region of the vertebral column." [http://orcid.org/0000-0002-6601-2165] synonym: "thoracic vertebra element" EXACT [https://github.com/obophenotype/uberon/wiki/Modeling-endochondral-elements-Design-Pattern] synonym: "thoracic vertebra skeletal element" BROAD [https://github.com/obophenotype/uberon/wiki/Modeling-endochondral-elements-Design-Pattern] is_a: UBERON:0005174 ! dorsal region element is_a: UBERON:0005181 ! thoracic segment organ is_a: UBERON:0010913 ! vertebral element intersection_of: UBERON:0010913 ! vertebral element intersection_of: BFO:0000050 UBERON:0006073 ! part of thoracic region of vertebral column union_of: UBERON:0002347 ! thoracic vertebra union_of: UBERON:0013507 ! thoracic vertebra cartilage element union_of: UBERON:0013508 ! thoracic vertebra pre-cartilage condensation relationship: BFO:0000050 UBERON:0006073 ! part of thoracic region of vertebral column property_value: skos:prefLabel "thoracic vertebra endochondral element" xsd:string [Term] id: UBERON:0015009 name: lumbar vertebra endochondral element def: "A lumbar vertebra bone or its cartilage or pre-cartilage precursor." [https://github.com/obophenotype/uberon/wiki/Modeling-endochondral-elements-Design-Pattern] synonym: "lumbar vertebra element" EXACT [https://github.com/obophenotype/uberon/wiki/Modeling-endochondral-elements-Design-Pattern] synonym: "lumbar vertebra skeletal element" BROAD [https://github.com/obophenotype/uberon/wiki/Modeling-endochondral-elements-Design-Pattern] is_a: UBERON:0005173 ! abdominal segment element is_a: UBERON:0005174 ! dorsal region element is_a: UBERON:0010913 ! vertebral element intersection_of: UBERON:0010913 ! vertebral element intersection_of: BFO:0000050 UBERON:0006074 ! part of lumbar region of vertebral column union_of: UBERON:0002414 ! lumbar vertebra union_of: UBERON:0013509 ! lumbar vertebra cartilage element union_of: UBERON:0013510 ! lumbar vertebra pre-cartilage condensation relationship: BFO:0000050 UBERON:0006074 ! part of lumbar region of vertebral column [Term] id: UBERON:0015010 name: sacral vertebra endochondral element def: "A vertebra endochondral element that is part of the sacral region of the vertebral column." [http://orcid.org/0000-0002-6601-2165] synonym: "sacral vertebra element" EXACT [https://github.com/obophenotype/uberon/wiki/Modeling-endochondral-elements-Design-Pattern] synonym: "sacral vertebra skeletal element" BROAD [https://github.com/obophenotype/uberon/wiki/Modeling-endochondral-elements-Design-Pattern] is_a: UBERON:0005174 ! dorsal region element is_a: UBERON:0005179 ! pelvic region element is_a: UBERON:0010913 ! vertebral element intersection_of: UBERON:0010913 ! vertebral element intersection_of: BFO:0000050 UBERON:0006075 ! part of sacral region of vertebral column union_of: UBERON:0001094 ! sacral vertebra union_of: UBERON:0010744 ! sacral vertebra pre-cartilage condensation union_of: UBERON:0010745 ! sacral vertebra cartilage element relationship: BFO:0000050 UBERON:0006075 ! part of sacral region of vertebral column [Term] id: UBERON:0015013 name: fibula endochondral element def: "The major postaxial endochondral element in the posterior zeugopod[Phenoscape]." [https://github.com/obophenotype/uberon/issues/73, PHENOSCAPE:mah] synonym: "fibula element" EXACT [https://github.com/obophenotype/uberon/wiki/Modeling-endochondral-elements-Design-Pattern] synonym: "fibula skeletal element" BROAD [https://github.com/obophenotype/uberon/wiki/Modeling-endochondral-elements-Design-Pattern] is_a: UBERON:0015022 ! hindlimb endochondral element union_of: UBERON:0001446 ! fibula union_of: UBERON:0010851 ! fibula cartilage element union_of: UBERON:0010852 ! fibula pre-cartilage condensation relationship: BFO:0000050 UBERON:0010720 ! part of hindlimb zeugopod skeleton property_value: terms:contributor https://orcid.org/0000-0001-9114-8737 property_value: terms:contributor https://orcid.org/0000-0002-6601-2165 [Term] id: UBERON:0015019 name: rib endochondral element def: "A rib bone or its cartilage or pre-cartilage precursor." [https://github.com/obophenotype/uberon/wiki/Modeling-endochondral-elements-Design-Pattern] synonym: "rib element" EXACT [https://github.com/obophenotype/uberon/wiki/Modeling-endochondral-elements-Design-Pattern] synonym: "rib skeletal element" BROAD [https://github.com/obophenotype/uberon/wiki/Modeling-endochondral-elements-Design-Pattern] is_a: BFO:0000002 is_a: UBERON:0010363 ! endochondral element union_of: UBERON:0002228 ! rib union_of: UBERON:0006288 ! rib cartilage element union_of: UBERON:0006289 ! rib pre-cartilage condensation relationship: BFO:0000050 UBERON:0014478 ! part of rib skeletal system [Term] id: UBERON:0015021 name: forelimb endochondral element def: "A forelimb bone or its cartilage or pre-cartilage precursor." [https://github.com/obophenotype/uberon/wiki/Modeling-endochondral-elements-Design-Pattern] synonym: "forelimb skeletal element" BROAD [https://github.com/obophenotype/uberon/wiki/Modeling-endochondral-elements-Design-Pattern] is_a: UBERON:0015061 ! limb endochondral element intersection_of: UBERON:0010363 ! endochondral element intersection_of: BFO:0000050 UBERON:0002102 ! part of forelimb union_of: UBERON:0008962 ! forelimb bone union_of: UBERON:0010883 ! forelimb cartilage element union_of: UBERON:0010884 ! forelimb bone pre-cartilage condensation relationship: BFO:0000050 UBERON:0001440 ! part of forelimb skeleton [Term] id: UBERON:0015022 name: hindlimb endochondral element def: "A hindlimb bone or its cartilage or pre-cartilage precursor." [https://github.com/obophenotype/uberon/wiki/Modeling-endochondral-elements-Design-Pattern] synonym: "hindlimb bone skeletal element" BROAD [https://github.com/obophenotype/uberon/wiki/Modeling-endochondral-elements-Design-Pattern] is_a: UBERON:0015061 ! limb endochondral element intersection_of: UBERON:0010363 ! endochondral element intersection_of: BFO:0000050 UBERON:0002103 ! part of hindlimb union_of: UBERON:0003464 ! hindlimb bone union_of: UBERON:0010885 ! hindlimb cartilage element union_of: UBERON:0010886 ! hindlimb pre-cartilage condensation relationship: BFO:0000050 UBERON:0001441 ! part of hindlimb skeleton [Term] id: UBERON:0015023 name: phalanx endochondral element def: "A phalanx bone or its cartilage or pre-cartilage precursor." [https://github.com/obophenotype/uberon/wiki/Modeling-endochondral-elements-Design-Pattern] synonym: "phalanx element" EXACT [https://github.com/obophenotype/uberon/wiki/Modeling-endochondral-elements-Design-Pattern] synonym: "phalanx skeletal element" BROAD [https://github.com/obophenotype/uberon/wiki/Modeling-endochondral-elements-Design-Pattern] is_a: UBERON:0015063 ! autopod endochondral element union_of: UBERON:0003221 ! phalanx union_of: UBERON:0010700 ! phalanx pre-cartilage condensation union_of: UBERON:0010701 ! phalanx cartilage element relationship: BFO:0000050 UBERON:0002544 ! part of digit relationship: BFO:0000050 UBERON:0012150 ! part of skeleton of digitopodium [Term] id: UBERON:0015024 name: manual digit phalanx endochondral element def: "A manual digit phalanx bone or its cartilage or pre-cartilage precursor." [https://github.com/obophenotype/uberon/wiki/Modeling-endochondral-elements-Design-Pattern] synonym: "manual digit phalanx element" EXACT [https://github.com/obophenotype/uberon/wiki/Modeling-endochondral-elements-Design-Pattern] synonym: "manual digit phalanx skeletal element" BROAD [https://github.com/obophenotype/uberon/wiki/Modeling-endochondral-elements-Design-Pattern] is_a: UBERON:0015021 ! forelimb endochondral element is_a: UBERON:0015023 ! phalanx endochondral element intersection_of: UBERON:0015023 ! phalanx endochondral element intersection_of: BFO:0000050 UBERON:0002389 ! part of manual digit union_of: UBERON:0001436 ! phalanx of manus union_of: UBERON:0010586 ! manual digit phalanx pre-cartilage condensation union_of: UBERON:0010686 ! manual digit phalanx cartilage element relationship: BFO:0000050 UBERON:0002389 ! part of manual digit relationship: BFO:0000050 UBERON:0010688 ! part of skeleton of manual acropodium relationship: BFO:0000050 UBERON:5102389 ! part of manual digit digitopodial skeleton [Term] id: UBERON:0015030 name: pedal digit phalanx endochondral element def: "A pedal digit phalanx bone or its cartilage or pre-cartilage precursor." [https://github.com/obophenotype/uberon/wiki/Modeling-endochondral-elements-Design-Pattern] synonym: "pedal digit phalanx element" EXACT [https://github.com/obophenotype/uberon/wiki/Modeling-endochondral-elements-Design-Pattern] synonym: "pedal digit phalanx skeletal element" BROAD [https://github.com/obophenotype/uberon/wiki/Modeling-endochondral-elements-Design-Pattern] is_a: UBERON:0015022 ! hindlimb endochondral element is_a: UBERON:0015023 ! phalanx endochondral element intersection_of: UBERON:0015023 ! phalanx endochondral element intersection_of: BFO:0000050 UBERON:0001466 ! part of pedal digit union_of: UBERON:0001449 ! phalanx of pes union_of: UBERON:0010585 ! pedal digit phalanx pre-cartilage condensation union_of: UBERON:0010685 ! pedal digit phalanx cartilage element relationship: BFO:0000050 UBERON:0001466 ! part of pedal digit relationship: BFO:0000050 UBERON:0010696 ! part of skeleton of pedal acropodium relationship: BFO:0000050 UBERON:5101466 ! part of pedal digit digitopodial skeleton [Term] id: UBERON:0015036 name: pedal digit metatarsal endochondral element def: "A pedal digit metatarsal bone or its cartilage or pre-cartilage precursor." [https://github.com/obophenotype/uberon/wiki/Modeling-endochondral-elements-Design-Pattern] synonym: "pedal digit metatarsal element" EXACT [https://github.com/obophenotype/uberon/wiki/Modeling-endochondral-elements-Design-Pattern] synonym: "pedal digit metatarsal skeletal element" BROAD [https://github.com/obophenotype/uberon/wiki/Modeling-endochondral-elements-Design-Pattern] is_a: UBERON:0015022 ! hindlimb endochondral element is_a: UBERON:0015063 ! autopod endochondral element intersection_of: UBERON:0010363 ! endochondral element intersection_of: BFO:0000050 UBERON:0000983 ! part of metatarsus region union_of: UBERON:0010545 ! metatarsus skeleton union_of: UBERON:0010687 ! pedal digit metatarsal pre-cartilage condensation union_of: UBERON:0010697 ! pedal digit metatarsal cartilage element relationship: BFO:0000050 UBERON:0000983 ! part of metatarsus region relationship: BFO:0000050 UBERON:0012152 ! part of skeleton of pedal digitopodium [Term] id: UBERON:0015042 name: manual digit metacarpus endochondral element def: "A manual digit metacarpus bone or its cartilage or pre-cartilage precursor." [https://github.com/obophenotype/uberon/wiki/Modeling-endochondral-elements-Design-Pattern] synonym: "manual digit metacarpus element" EXACT [https://github.com/obophenotype/uberon/wiki/Modeling-endochondral-elements-Design-Pattern] synonym: "manual digit metacarpus skeletal element" BROAD [https://github.com/obophenotype/uberon/wiki/Modeling-endochondral-elements-Design-Pattern] is_a: UBERON:0015021 ! forelimb endochondral element is_a: UBERON:0015063 ! autopod endochondral element intersection_of: UBERON:0010363 ! endochondral element intersection_of: BFO:0000050 UBERON:0004453 ! part of metacarpus region union_of: UBERON:0010544 ! metacarpus skeleton union_of: UBERON:0010698 ! manual digit metacarpus pre-cartilage condensation union_of: UBERON:0010699 ! manual digit metacarpus cartilage element relationship: BFO:0000050 UBERON:0004453 ! part of metacarpus region relationship: BFO:0000050 UBERON:0012151 ! part of skeleton of manual digitopodium [Term] id: UBERON:0015049 name: carpus endochondral element def: "A carpus bone or its cartilage or pre-cartilage precursor." [https://github.com/obophenotype/uberon/wiki/Modeling-endochondral-elements-Design-Pattern] synonym: "carpus element" EXACT [https://github.com/obophenotype/uberon/wiki/Modeling-endochondral-elements-Design-Pattern] synonym: "carpus skeletal element" BROAD [https://github.com/obophenotype/uberon/wiki/Modeling-endochondral-elements-Design-Pattern] is_a: UBERON:0015021 ! forelimb endochondral element is_a: UBERON:0015063 ! autopod endochondral element intersection_of: UBERON:0010363 ! endochondral element intersection_of: BFO:0000050 UBERON:0004452 ! part of carpal region union_of: UBERON:0001435 ! carpal bone union_of: UBERON:0006213 ! carpus cartilage element union_of: UBERON:0006214 ! carpus pre-cartilage condensation relationship: BFO:0000050 UBERON:0009880 ! part of carpal skeleton [Term] id: UBERON:0015050 name: tarsus endochondral element def: "A tarsus bone or its cartilage or pre-cartilage precursor." [https://github.com/obophenotype/uberon/wiki/Modeling-endochondral-elements-Design-Pattern] synonym: "tarsus element" EXACT [https://github.com/obophenotype/uberon/wiki/Modeling-endochondral-elements-Design-Pattern] synonym: "tarsus skeletal element" BROAD [https://github.com/obophenotype/uberon/wiki/Modeling-endochondral-elements-Design-Pattern] is_a: UBERON:0015022 ! hindlimb endochondral element is_a: UBERON:0015063 ! autopod endochondral element intersection_of: UBERON:0010363 ! endochondral element intersection_of: BFO:0000050 UBERON:0004454 ! part of tarsal region union_of: UBERON:0001447 ! tarsal bone union_of: UBERON:0010540 ! tarsus pre-cartilage condensation union_of: UBERON:0010541 ! tarsus cartilage element relationship: BFO:0000050 UBERON:0009879 ! part of tarsal skeleton [Term] id: UBERON:0015052 name: femur endochondral element def: "A femur bone or its cartilage or pre-cartilage precursor." [https://github.com/obophenotype/uberon/wiki/Modeling-endochondral-elements-Design-Pattern] synonym: "femur element" EXACT [https://github.com/obophenotype/uberon/wiki/Modeling-endochondral-elements-Design-Pattern] synonym: "femur skeletal element" BROAD [https://github.com/obophenotype/uberon/wiki/Modeling-endochondral-elements-Design-Pattern] is_a: UBERON:0015022 ! hindlimb endochondral element union_of: UBERON:0000981 ! femur union_of: UBERON:0006234 ! femur pre-cartilage condensation union_of: UBERON:0010129 ! femur cartilage element relationship: BFO:0000050 UBERON:0000376 ! part of hindlimb stylopod [Term] id: UBERON:0015053 name: humerus endochondral element def: "A humerus bone or its cartilage or pre-cartilage precursor." [https://github.com/obophenotype/uberon/wiki/Modeling-endochondral-elements-Design-Pattern] synonym: "humerus element" EXACT [https://github.com/obophenotype/uberon/wiki/Modeling-endochondral-elements-Design-Pattern] synonym: "humerus skeletal element" BROAD [https://github.com/obophenotype/uberon/wiki/Modeling-endochondral-elements-Design-Pattern] is_a: UBERON:0015021 ! forelimb endochondral element union_of: UBERON:0000976 ! humerus union_of: UBERON:0006245 ! humerus cartilage element union_of: UBERON:0006246 ! humerus pre-cartilage condensation relationship: BFO:0000050 UBERON:0003822 ! part of forelimb stylopod [Term] id: UBERON:0015054 name: iliac endochondral element def: "An iliac bone or its cartilage or pre-cartilage precursor." [https://github.com/obophenotype/uberon/wiki/Modeling-endochondral-elements-Design-Pattern] synonym: "iliac element" EXACT [https://github.com/obophenotype/uberon/wiki/Modeling-endochondral-elements-Design-Pattern] synonym: "iliac skeletal element" BROAD [https://github.com/obophenotype/uberon/wiki/Modeling-endochondral-elements-Design-Pattern] is_a: BFO:0000002 is_a: UBERON:0005179 ! pelvic region element is_a: UBERON:0010363 ! endochondral element union_of: UBERON:0001273 ! ilium union_of: UBERON:0006247 ! iliac pre-cartilage condensation union_of: UBERON:0010714 ! iliac cartilage element relationship: BFO:0000050 UBERON:0007832 ! part of pelvic girdle skeleton [Term] id: UBERON:0015056 name: ischial endochondral element def: "An ischial bone or its cartilage or pre-cartilage precursor." [https://github.com/obophenotype/uberon/wiki/Modeling-endochondral-elements-Design-Pattern] synonym: "ischial element" EXACT [https://github.com/obophenotype/uberon/wiki/Modeling-endochondral-elements-Design-Pattern] synonym: "ischial skeletal element" BROAD [https://github.com/obophenotype/uberon/wiki/Modeling-endochondral-elements-Design-Pattern] is_a: BFO:0000002 is_a: UBERON:0005179 ! pelvic region element is_a: UBERON:0010363 ! endochondral element union_of: UBERON:0001274 ! ischium union_of: UBERON:0006254 ! ischial cartilage element union_of: UBERON:0006255 ! ischial pre-cartilage condensation relationship: BFO:0000050 UBERON:0007832 ! part of pelvic girdle skeleton [Term] id: UBERON:0015057 name: scapula endochondral element def: "A scapula bone or its cartilage or pre-cartilage precursor." [https://github.com/obophenotype/uberon/wiki/Modeling-endochondral-elements-Design-Pattern] synonym: "scapula element" EXACT [https://github.com/obophenotype/uberon/wiki/Modeling-endochondral-elements-Design-Pattern] synonym: "scapula skeletal element" BROAD [https://github.com/obophenotype/uberon/wiki/Modeling-endochondral-elements-Design-Pattern] is_a: BFO:0000002 is_a: UBERON:0010363 ! endochondral element union_of: UBERON:0006290 ! scapula cartilage element union_of: UBERON:0006291 ! scapula pre-cartilage condensation union_of: UBERON:0006849 ! scapula relationship: BFO:0000050 UBERON:0007831 ! part of pectoral girdle skeleton [Term] id: UBERON:0015059 name: orbitosphenoid endochondral element def: "An orbitosphenoid bone or its cartilage or pre-cartilage precursor." [https://github.com/obophenotype/uberon/wiki/Modeling-endochondral-elements-Design-Pattern] synonym: "orbitosphenoid element" EXACT [https://github.com/obophenotype/uberon/wiki/Modeling-endochondral-elements-Design-Pattern] synonym: "orbitosphenoid skeletal element" BROAD [https://github.com/obophenotype/uberon/wiki/Modeling-endochondral-elements-Design-Pattern] is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0010363 ! endochondral element union_of: UBERON:0002478 ! orbitosphenoid union_of: UBERON:0005687 ! orbitosphenoid cartilage element union_of: UBERON:0010728 ! sphenoid lesser wing pre-cartilage condensation relationship: BFO:0000050 UBERON:0002517 ! part of basicranium relationship: BFO:0000050 UBERON:0003111 ! part of sphenoid region property_value: skos:prefLabel "orbitosphenoid endochondral element" xsd:string [Term] id: UBERON:0015060 name: sphenoid endochondral element def: "A sphenoid bone or its cartilage or pre-cartilage precursor." [https://github.com/obophenotype/uberon/wiki/Modeling-endochondral-elements-Design-Pattern] synonym: "sphenoid bone skeletal element" BROAD [https://github.com/obophenotype/uberon/wiki/Modeling-endochondral-elements-Design-Pattern] synonym: "sphenoid element" EXACT [https://github.com/obophenotype/uberon/wiki/Modeling-endochondral-elements-Design-Pattern] is_a: BFO:0000002 is_a: UBERON:0010363 ! endochondral element union_of: UBERON:0001677 ! sphenoid bone union_of: UBERON:0009191 ! sphenoid bone pre-cartilage condensation union_of: UBERON:0009193 ! sphenoid cartilage element relationship: BFO:0000050 UBERON:0011156 ! part of facial skeleton property_value: skos:prefLabel "sphenoid endochondral element" xsd:string [Term] id: UBERON:0015061 name: limb endochondral element def: "A limb bone or its cartilage or pre-cartilage precursor." [https://github.com/obophenotype/uberon/wiki/Modeling-endochondral-elements-Design-Pattern] synonym: "limb bone endochondral element" EXACT [https://github.com/obophenotype/uberon/wiki/Modeling-endochondral-elements-Design-Pattern] synonym: "limb bone skeletal element" BROAD [https://github.com/obophenotype/uberon/wiki/Modeling-endochondral-elements-Design-Pattern] is_a: BFO:0000002 is_a: UBERON:0010363 ! endochondral element intersection_of: UBERON:0010363 ! endochondral element intersection_of: BFO:0000050 UBERON:0002101 ! part of limb union_of: UBERON:0002428 ! limb bone union_of: UBERON:0010881 ! limb cartilage element union_of: UBERON:0010882 ! limb bone pre-cartilage condensation relationship: BFO:0000050 UBERON:0004381 ! part of skeleton of limb [Term] id: UBERON:0015063 name: autopod endochondral element def: "An endochondral element that is part of a autopod region." [OBOL:automatic] is_a: UBERON:0015061 ! limb endochondral element intersection_of: UBERON:0010363 ! endochondral element intersection_of: BFO:0000050 UBERON:0002470 ! part of autopod region relationship: BFO:0000050 UBERON:0006717 {source="cjm"} ! part of autopodial skeleton [Term] id: UBERON:0015064 name: autopod cartilage def: "An autopod endochondral element that is composed primarily of cartilage tissue." [OBOL:automatic] is_a: UBERON:0010881 ! limb cartilage element is_a: UBERON:0015063 ! autopod endochondral element intersection_of: UBERON:0015063 ! autopod endochondral element intersection_of: RO:0002473 UBERON:0002418 ! composed primarily of cartilage tissue [Term] id: UBERON:0015078 name: proximal carpal endochondral element def: "A proximal mesopodial endochondral element that is part of a forelimb." [OBOL:automatic] synonym: "proximal carpal" RELATED SYSTEMATIC [UBERON:cjm] synonym: "proximal carpal element" EXACT [UBERON:cjm] is_a: UBERON:0015049 ! carpus endochondral element is_a: UBERON:0017750 ! proximal mesopodial endochondral element intersection_of: UBERON:0017750 ! proximal mesopodial endochondral element intersection_of: BFO:0000050 UBERON:0002102 ! part of forelimb [Term] id: UBERON:0015079 name: proximal carpal cartilage def: "A proximal carpal endochondral element that is composed primarily of cartilage tissue." [OBOL:automatic] is_a: UBERON:0015078 ! proximal carpal endochondral element is_a: UBERON:0017751 ! proximal mesopodial cartilage element is_a: UBERON:0035128 ! manus cartilage element intersection_of: UBERON:0015078 ! proximal carpal endochondral element intersection_of: RO:0002473 UBERON:0002418 ! composed primarily of cartilage tissue relationship: RO:0002202 UBERON:0015080 ! develops from proximal carpal bone pre-cartilage condensation [Term] id: UBERON:0015080 name: proximal carpal bone pre-cartilage condensation def: "A proximal carpal endochondral element that is composed primarily of a pre-cartilage condensation." [OBOL:automatic] is_a: UBERON:0010884 ! forelimb bone pre-cartilage condensation is_a: UBERON:0015078 ! proximal carpal endochondral element intersection_of: UBERON:0015078 ! proximal carpal endochondral element intersection_of: RO:0002473 UBERON:0005866 ! composed primarily of pre-cartilage condensation [Term] id: UBERON:0015081 name: proximal tarsal endochondral element def: "A proximal mesopodial endochondral element that is part of a hindlimb." [OBOL:automatic] synonym: "proximal tarsal" RELATED SYSTEMATIC [UBERON:cjm] is_a: UBERON:0015050 ! tarsus endochondral element is_a: UBERON:0017750 ! proximal mesopodial endochondral element intersection_of: UBERON:0017750 ! proximal mesopodial endochondral element intersection_of: BFO:0000050 UBERON:0002103 ! part of hindlimb [Term] id: UBERON:0015082 name: proximal tarsal cartilage def: "A proximal tarsal endochondral element that is composed primarily of cartilage tissue." [OBOL:automatic] is_a: UBERON:0015081 ! proximal tarsal endochondral element is_a: UBERON:0017751 ! proximal mesopodial cartilage element is_a: UBERON:0035129 ! pes cartilage element intersection_of: UBERON:0015081 ! proximal tarsal endochondral element intersection_of: RO:0002473 UBERON:0002418 ! composed primarily of cartilage tissue relationship: RO:0002202 UBERON:0015083 ! develops from proximal tarsal bone pre-cartilage condensation [Term] id: UBERON:0015083 name: proximal tarsal bone pre-cartilage condensation def: "A proximal tarsal endochondral element that is composed primarily of a pre-cartilage condensation." [OBOL:automatic] is_a: UBERON:0010886 ! hindlimb pre-cartilage condensation is_a: UBERON:0015081 ! proximal tarsal endochondral element intersection_of: UBERON:0015081 ! proximal tarsal endochondral element intersection_of: RO:0002473 UBERON:0005866 ! composed primarily of pre-cartilage condensation [Term] id: UBERON:0015128 name: subepicardial layer of epicardium synonym: "perimysial connective tissue of subepicardium" EXACT [FMA:83105] synonym: "subepicardial connective tissue" EXACT [FMA:83105] xref: FMA:83105 is_a: UBERON:0007188 ! mesothelium of serous pericardium relationship: BFO:0000050 UBERON:0002348 {source="FMA"} ! part of epicardium property_value: IAO:0000116 "consider merging into myocardial compact layer" xsd:string property_value: skos:prefLabel "subepicardial layer of epicardium" xsd:string [Term] id: UBERON:0015129 name: epicardial fat def: "Visceral intrapericardial fat contiguous with the myocardial surface." [DOI:10.5935/abc.20130138] synonym: "epicardial adipose tissue" EXACT [] synonym: "pericardial adipose tissue" EXACT [] xref: FMA:9871 is_a: UBERON:0003837 ! thoracic segment connective tissue is_a: UBERON:0035814 ! pericardial fat intersection_of: UBERON:0001013 ! adipose tissue intersection_of: RO:0002220 UBERON:0002348 ! adjacent to epicardium intersection_of: RO:0002220 UBERON:0002425 ! adjacent to visceral serous pericardium intersection_of: RO:0002221 UBERON:0000948 ! surrounds heart relationship: BFO:0000050 UBERON:0015128 ! part of subepicardial layer of epicardium relationship: RO:0002220 UBERON:0002348 ! adjacent to epicardium relationship: RO:0002220 UBERON:0002425 ! adjacent to visceral serous pericardium relationship: RO:0002473 CL:1000309 ! composed primarily of epicardial adipocyte property_value: skos:prefLabel "epicardial fat" xsd:string [Term] id: UBERON:0015130 name: connective tissue of prostate gland def: "A portion of connective tissue that is part of a prostate gland." [OBOL:automatic] synonym: "connective tissue of prostate" EXACT [FMA:74165] xref: FMA:74165 is_a: UBERON:0005156 ! reproductive structure is_a: UBERON:0011822 {source="FMA"} ! dense irregular connective tissue intersection_of: UBERON:0002384 ! connective tissue intersection_of: BFO:0000050 UBERON:0002367 ! part of prostate gland relationship: BFO:0000050 UBERON:0002367 ! part of prostate gland [Term] id: UBERON:0015144 name: autopod hair def: "A strand of hair that is part of a autopod region." [OBOL:automatic] synonym: "hair of hand/foot" EXACT [] synonym: "hand/foot hair" EXACT [] synonym: "paw hair" NARROW [] is_a: UBERON:0037459 ! hair of limb intersection_of: UBERON:0001037 ! strand of hair intersection_of: BFO:0000050 UBERON:0002470 ! part of autopod region relationship: BFO:0000050 UBERON:0002470 ! part of autopod region [Term] id: UBERON:0015145 name: pes hair def: "A strand of hair that is part of a pes." [OBOL:automatic] synonym: "foot hair" EXACT [] synonym: "hair of foot" EXACT [] synonym: "hind foot hair" EXACT [] synonym: "hind paw hair" NARROW [] is_a: UBERON:0015144 ! autopod hair intersection_of: UBERON:0001037 ! strand of hair intersection_of: BFO:0000050 UBERON:0002387 ! part of pes relationship: BFO:0000050 UBERON:0002387 ! part of pes [Term] id: UBERON:0015146 name: manus hair def: "A strand of hair that is part of a manus." [OBOL:automatic] synonym: "front paw hair" NARROW [] synonym: "hair of hand" EXACT [] synonym: "hand hair" EXACT [] is_a: UBERON:0015144 ! autopod hair intersection_of: UBERON:0001037 ! strand of hair intersection_of: BFO:0000050 UBERON:0002398 ! part of manus relationship: BFO:0000050 UBERON:0002398 ! part of manus [Term] id: UBERON:0015147 name: pinna hair def: "A strand of hair that is part of a pinna." [OBOL:automatic] subset: pheno_slim synonym: "ear hair" RELATED [] is_a: UBERON:0022279 ! strand of hair on external ear intersection_of: UBERON:0001037 ! strand of hair intersection_of: BFO:0000050 UBERON:0001757 ! part of pinna relationship: BFO:0000050 UBERON:0001757 ! part of pinna [Term] id: UBERON:0015148 name: tail hair def: "A strand of hair that is part of a tail." [OBOL:automatic] subset: pheno_slim xref: EMAPA:37971 {source="MA:th"} is_a: UBERON:0001037 ! strand of hair intersection_of: UBERON:0001037 ! strand of hair intersection_of: BFO:0000050 UBERON:0002415 ! part of tail relationship: BFO:0000050 UBERON:0002415 ! part of tail [Term] id: UBERON:0015149 name: ventral hair def: "A strand of hair that is part of a ventrum." [OBOL:automatic] synonym: "ventral coat hair" RELATED [] is_a: UBERON:0001037 ! strand of hair intersection_of: UBERON:0001037 ! strand of hair intersection_of: BFO:0000050 UBERON:0013235 ! part of ventrum relationship: BFO:0000050 UBERON:0013235 ! part of ventrum [Term] id: UBERON:0015150 name: dorsal hair def: "A strand of hair that is part of a dorsum." [OBOL:automatic] synonym: "back hair" RELATED [] synonym: "dorsal coat hair" RELATED [] synonym: "hair of back" RELATED [FMA:54320] xref: FMA:54320 is_a: UBERON:0001037 ! strand of hair intersection_of: UBERON:0001037 ! strand of hair intersection_of: BFO:0000050 UBERON:0001137 ! part of dorsum relationship: BFO:0000050 UBERON:0001137 ! part of dorsum [Term] id: UBERON:0015152 name: gland of ocular region def: "A gland that is typically found in or near the orbital region, in or around either the medial or lateral canthi, and is typically associated with secretions onto the eyeball or associated ducts. Includes the Harderian, nictitans and lacrimal glands." [http://orcid.org/0000-0002-6601-2165, https://github.com/obophenotype/uberon/issues/614] synonym: "ocular gland" EXACT [] synonym: "orbital gland" RELATED [] is_a: UBERON:0002530 ! gland intersection_of: UBERON:0002530 ! gland intersection_of: BFO:0000050 UBERON:0004088 ! part of orbital region relationship: BFO:0000050 UBERON:0035639 {source="inferred"} ! part of ocular adnexa property_value: skos:prefLabel "gland of ocular region" xsd:string property_value: terms:contributor https://orcid.org/0000-0002-6601-2165 [Term] id: UBERON:0015154 name: lateral gland of orbital region def: "A gland that is located in or around the ocular region, nearer the outer canthi." [http://orcid.org/0000-0002-6601-2165] synonym: "lateral ocular gland" EXACT [] synonym: "lateral orbital gland" EXACT [] is_a: UBERON:0015152 ! gland of ocular region [Term] id: UBERON:0015155 name: conjunctival space def: "An anatomical space that is enclosed by a conjunctiva." [OBOL:automatic] synonym: "cavity of conjunctival sac" EXACT [FMA:59083] synonym: "conjunctival sac cavity" EXACT [FMA:59083] synonym: "subbrillar space" NARROW [NCBITaxon:8570, PMID:7559104] synonym: "subconjunctival space" EXACT [] xref: FMA:59083 xref: SCTID:280957009 is_a: UBERON:0000464 ! anatomical space intersection_of: UBERON:0000464 ! anatomical space intersection_of: RO:0002572 UBERON:0001811 ! luminal space of conjunctiva relationship: RO:0002572 UBERON:0001811 ! luminal space of conjunctiva [Term] id: UBERON:0015165 name: multi-unit eye def: "An eye consisting of multiple light-sensing organs." [http://orcid.org/0000-0002-6601-2165, PMID:21062451] is_a: UBERON:0000970 ! eye intersection_of: UBERON:0000970 ! eye intersection_of: RO:0002473 UBERON:0000020 ! composed primarily of sense organ relationship: RO:0002473 UBERON:0000020 ! composed primarily of sense organ property_value: RO:0002161 NCBITaxon:7742 property_value: skos:prefLabel "multi-unit eye" xsd:string [Term] id: UBERON:0015172 name: endometrial blood vessel def: "A blood vessel that is part of a endometrium." [OBOL:automatic] subset: human_reference_atlas synonym: "blood vessel of endometrium" EXACT [] xref: SCTID:254200009 is_a: UBERON:0001981 ! blood vessel is_a: UBERON:0005156 ! reproductive structure intersection_of: UBERON:0001981 ! blood vessel intersection_of: BFO:0000050 UBERON:0001295 ! part of endometrium relationship: BFO:0000050 UBERON:0001295 ! part of endometrium property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0015178 name: somite border def: "A region of somite adjacent to presomitic mesoderm." [http://orcid.org/0000-0002-6601-2165] subset: pheno_slim synonym: "inter-somited border" RELATED [] synonym: "intersomitic boundary" RELATED [] synonym: "intersomitic fissure" RELATED [] synonym: "intersomitic junction" RELATED [XAO:0004074] synonym: "segmental border" RELATED [] synonym: "somite boundary" RELATED [ZFA:0001462] xref: TAO:0001462 xref: XAO:0004074 xref: ZFA:0001462 is_a: UBERON:0007651 ! anatomical junction intersection_of: UBERON:0007651 ! anatomical junction intersection_of: BFO:0000050 UBERON:0002329 ! part of somite intersection_of: RO:0002220 UBERON:0003059 ! adjacent to presomitic mesoderm relationship: BFO:0000050 UBERON:0002329 ! part of somite relationship: RO:0002220 UBERON:0003059 ! adjacent to presomitic mesoderm property_value: skos:prefLabel "somite border" xsd:string [Term] id: UBERON:0015179 name: somite boundary epithelium def: "Epithelium located in the intersomitic region." [XAO:0004077, XAO:EJS] synonym: "intersomitic epithelium" EXACT [XAO:0004077] synonym: "intersomitic membrane" EXACT [XAO:0004077] xref: XAO:0004077 is_a: UBERON:0000483 ! epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: BFO:0000050 UBERON:0015178 ! part of somite border relationship: BFO:0000050 UBERON:0015178 ! part of somite border property_value: skos:prefLabel "somite boundary epithelium" xsd:string [Term] id: UBERON:0015181 name: neck of tooth def: "The slightly constricted part of a tooth, between the crown and the root." [http://www.medilexicon.com/medicaldictionary.php?s=neck+of+tooth] synonym: "cervical margin of tooth" RELATED [http://www.medilexicon.com/medicaldictionary.php?s=neck+of+tooth] synonym: "cervical zone of tooth" RELATED [http://www.medilexicon.com/medicaldictionary.php?s=neck+of+tooth] synonym: "cervix dentis" EXACT OMO:0003011 [FMA:TA] synonym: "cervix of tooth" EXACT [FMA:55627] synonym: "collumn dentis" EXACT OMO:0003011 [ncithesaurus:Collum_Dentis] synonym: "dental neck" EXACT [http://www.medilexicon.com/medicaldictionary.php?s=neck+of+tooth] synonym: "tooth neck" EXACT [FMA:55627] xref: FMA:55627 xref: NCIT:C32346 xref: SCTID:28638008 is_a: UBERON:0001560 ! neck of organ intersection_of: UBERON:0001560 ! neck of organ intersection_of: BFO:0000050 UBERON:0001091 ! part of calcareous tooth relationship: BFO:0000050 UBERON:0001091 ! part of calcareous tooth [Term] id: UBERON:0015203 name: non-connected functional system def: "An anatomical group whose component structures share a common function." [AEO:0000093, AEO:JB, FBbt:00007278, FBC:DOS] xref: AEO:0000093 xref: FBbt:00007278 {sssom:mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"} is_a: UBERON:0034923 ! disconnected anatomical group property_value: skos:prefLabel "non-connected functional system" xsd:string [Term] id: UBERON:0015204 name: glandular system def: "A non-connected functional system that is composed primarily of a gland." [OBOL:automatic] xref: EHDAA2:0002223 is_a: UBERON:0015203 ! non-connected functional system intersection_of: UBERON:0015203 ! non-connected functional system intersection_of: RO:0002473 UBERON:0002530 ! composed primarily of gland relationship: RO:0002473 UBERON:0002530 ! composed primarily of gland property_value: skos:prefLabel "glandular system" xsd:string [Term] id: UBERON:0015212 name: lateral structure def: "Any structure that is placed on one side of the left-right axis of a bilaterian." [http://orcid.org/0000-0002-6601-2165] subset: grouping_class subset: non_informative is_a: UBERON:0000061 ! anatomical structure intersection_of: UBERON:0000061 ! anatomical structure intersection_of: BSPO:0000126 UBERON:0000465 ! material anatomical entity relationship: BSPO:0000126 UBERON:0000465 ! material anatomical entity relationship: RO:0002162 NCBITaxon:33213 ! in taxon Bilateria property_value: skos:prefLabel "lateral structure" xsd:string [Term] id: UBERON:0015214 name: arcuate ligament def: "A ligament that is part of a diaphragm." [OBOL:automatic] xref: EMAPA:19236 xref: FMA:58280 is_a: UBERON:0000211 ! ligament is_a: UBERON:0005181 ! thoracic segment organ intersection_of: UBERON:0000211 ! ligament intersection_of: BFO:0000050 UBERON:0001103 ! part of diaphragm relationship: BFO:0000050 UBERON:0001103 ! part of diaphragm [Term] id: UBERON:0015228 name: circulatory organ def: "A hollow, muscular organ, which, by contracting rhythmically, contributes to the circulation of lymph, blood or analogs. Examples: a chambered vertebrate heart; the tubular peristaltic heart of ascidians; the dorsal vessel of an insect; the lymoh heart of a reptile." [http://orcid.org/0000-0002-6601-2165] subset: grouping_class synonym: "cardiac pump" EXACT [] synonym: "cardiac structure" RELATED [] synonym: "circulatory vessel" NARROW [] synonym: "heart" BROAD [] synonym: "heart or heart like organ" EXACT [] is_a: UBERON:0003103 ! compound organ relationship: BFO:0000050 UBERON:0001009 ! part of circulatory system relationship: RO:0000086 PATO:0001690 ! has quality contractile property_value: skos:prefLabel "circulatory organ" xsd:string [Term] id: UBERON:0015233 name: nucleus of dorsal thalamus def: "A nucleus of brain that is part of a dorsal thalamus." [OBOL:automatic] synonym: "dorsal thalamic nucleus" EXACT [] synonym: "nucleus of thalamus proper" EXACT [] is_a: UBERON:0007692 ! nucleus of thalamus intersection_of: UBERON:0002308 ! nucleus of brain intersection_of: BFO:0000050 UBERON:0004703 ! part of dorsal thalamus relationship: BFO:0000050 UBERON:0004703 ! part of dorsal thalamus property_value: skos:prefLabel "nucleus of dorsal thalamus" xsd:string [Term] id: UBERON:0015234 name: nucleus of ventral thalamus def: "A nucleus of brain that is part of a ventral thalamus." [OBOL:automatic] synonym: "ventral thalamic nucleus" EXACT [] is_a: UBERON:0007692 ! nucleus of thalamus intersection_of: UBERON:0002308 ! nucleus of brain intersection_of: BFO:0000050 UBERON:0001900 ! part of ventral thalamus relationship: BFO:0000050 UBERON:0001900 ! part of ventral thalamus property_value: skos:prefLabel "nucleus of ventral thalamus" xsd:string [Term] id: UBERON:0015238 name: pineal complex def: "A cluster in the epithalamus that consists of the pineal body and any associated structures, such as the parapineal gland or the parietal organ. The complex is poorly developed in mammals." [http://orcid.org/0000-0002-6601-2165] xref: TAO:0001359 xref: ZFA:0001359 is_a: BFO:0000004 is_a: UBERON:0000477 ! anatomical cluster relationship: BFO:0000050 UBERON:0001899 {source="ZFA"} ! part of epithalamus property_value: skos:prefLabel "pineal complex" xsd:string [Term] id: UBERON:0015249 name: digit skin def: "A zone of skin that is part of a digit [Automatically generated definition]." [OBOL:automatic] subset: pheno_slim xref: EMAPA:32615 xref: MA:0003011 is_a: UBERON:0015790 ! autopod skin intersection_of: UBERON:0000014 ! zone of skin intersection_of: BFO:0000050 UBERON:0002544 ! part of digit relationship: BFO:0000050 UBERON:0002544 ! part of digit [Term] id: UBERON:0015280 name: pancreas left lobe def: "A pancreatic lobule that is in_the_left_side_of a exocrine pancreas." [OBOL:automatic] xref: EMAPA:37711 {source="MA:th"} xref: MA:0000722 is_a: UBERON:0007324 ! pancreatic lobule is_a: UBERON:0015212 ! lateral structure intersection_of: UBERON:0007324 ! pancreatic lobule intersection_of: BSPO:0000120 UBERON:0000017 ! exocrine pancreas relationship: BSPO:0000120 UBERON:0000017 ! exocrine pancreas property_value: skos:prefLabel "pancreas left lobe" xsd:string [Term] id: UBERON:0015281 name: pancreas right lobe def: "A pancreatic lobule that is in_the_right_side_of a exocrine pancreas." [OBOL:automatic] xref: EMAPA:37712 {source="MA:th"} xref: MA:0000723 is_a: UBERON:0007324 ! pancreatic lobule is_a: UBERON:0015212 ! lateral structure intersection_of: UBERON:0007324 ! pancreatic lobule intersection_of: BSPO:0000121 UBERON:0000017 ! exocrine pancreas relationship: BSPO:0000121 UBERON:0000017 ! exocrine pancreas property_value: skos:prefLabel "pancreas right lobe" xsd:string [Term] id: UBERON:0015329 name: respiratory system basement membrane def: "A basement membrane of epithelium that is part of a respiratory system." [OBOL:automatic] xref: EMAPA:37570 {source="MA:th"} xref: MA:0001815 is_a: UBERON:0005769 ! basement membrane of epithelium intersection_of: UBERON:0005769 ! basement membrane of epithelium intersection_of: BFO:0000050 UBERON:0001004 ! part of respiratory system relationship: BFO:0000050 UBERON:0003570 {source="MA"} ! part of respiratory system connective tissue property_value: skos:prefLabel "respiratory system basement membrane" xsd:string [Term] id: UBERON:0015410 name: heart plus pericardium subset: human_reference_atlas synonym: "heart/pericardium" EXACT [MA:0002449] xref: EMAPA:37597 {source="MA:th"} xref: MA:0002449 is_a: UBERON:0005178 {source="MA"} ! thoracic cavity element relationship: BFO:0000050 UBERON:0004535 ! part of cardiovascular system property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "heart plus pericardium" xsd:string [Term] id: UBERON:0015418 name: urethra mesenchymal layer def: "A mesenchyme that is part of a urethra." [OBOL:automatic] xref: EMAPA:37786 {source="MA:th"} xref: MA:0002648 is_a: UBERON:0003104 ! mesenchyme intersection_of: UBERON:0003104 ! mesenchyme intersection_of: BFO:0000050 UBERON:0000057 ! part of urethra relationship: BFO:0000050 UBERON:0000057 ! part of urethra [Term] id: UBERON:0015420 name: ureteral valve def: "A valve that is part of a ureter." [OBOL:automatic] synonym: "ureteral valve" EXACT [MA:0002658] synonym: "valve or ureter" EXACT [] xref: EMAPA:37781 {source="MA:th"} xref: MA:0002658 is_a: UBERON:0003978 ! valve intersection_of: UBERON:0003978 ! valve intersection_of: BFO:0000050 UBERON:0000056 ! part of ureter relationship: BFO:0000050 UBERON:0000056 ! part of ureter relationship: RO:0002215 GO:0035809 ! capable of regulation of urine volume [Term] id: UBERON:0015453 name: subcutaneous lymph node def: "A lymph node that is part of a hypodermis." [OBOL:automatic] xref: MA:0003028 is_a: UBERON:0000029 ! lymph node intersection_of: UBERON:0000029 ! lymph node intersection_of: BFO:0000050 UBERON:0002072 ! part of hypodermis relationship: BFO:0000050 UBERON:0002072 ! part of hypodermis [Term] id: UBERON:0015474 name: axilla skin def: "A zone of skin that is part of a axilla." [OBOL:automatic] synonym: "axillary skin" EXACT [FMA:37322] synonym: "skin of armpit" EXACT [PMID:38565739] synonym: "skin of axilla" EXACT [FMA:37322] xref: EMAPA:37349 {source="MA:th"} xref: FMA:37322 xref: MA:0003087 xref: NCIT:C116164 is_a: UBERON:8480025 ! skin of clavicle region intersection_of: UBERON:0000014 ! zone of skin intersection_of: BFO:0000050 UBERON:0009472 ! part of axilla relationship: BFO:0000050 UBERON:0009472 ! part of axilla [Term] id: UBERON:0015476 name: nose skin def: "A zone of skin that is part of a external nose." [OBOL:automatic] synonym: "external nasal skin" EXACT [FMA:24763] synonym: "skin of external nose" EXACT [FMA:24763] synonym: "skin of nose" EXACT [FMA:24763] xref: EMAPA:37684 {source="MA:th"} xref: FMA:24763 xref: MA:0003090 is_a: UBERON:1000021 ! skin of face intersection_of: UBERON:0000014 ! zone of skin intersection_of: BFO:0000050 UBERON:0007827 ! part of external nose relationship: BFO:0000050 UBERON:0007827 ! part of external nose [Term] id: UBERON:0015480 name: proper hepatic artery def: "The hepatic artery proper (also proper hepatic artery), arises from the common hepatic artery and runs alongside the portal vein and the common bile duct to form the portal triad. The hepatic artery proper gives off a small supraduodenal artery to the duodenal bulb. Then the right gastric artery comes off and runs to the left along the lesser curvature of the stomach to meet the left gastric artery, which is a branch of the celiac trunk. It subsequently gives off the cystic artery, which feeds the gallbladder, before bifurcating into the right and left hepatic arteries. Of note, the right and left hepatic arteries may demonstrate variant anatomy. A replaced right hepatic artery may arise from the superior mesenteric artery (SMA) and a replaced left hepatic artery may arise from the left gastric artery." [Wikipedia:Hepatic_artery_proper] subset: human_reference_atlas synonym: "hepatic artery proper" EXACT [FMA:14772] synonym: "proper hepatic" RELATED [Wikipedia:Hepatic_artery_proper] xref: EMAPA:37217 {source="MA:th"} xref: FMA:14772 xref: MA:0003095 xref: SCTID:244262006 xref: Wikipedia:Hepatic_artery_proper is_a: UBERON:0001193 {source="MA"} ! hepatic artery relationship: RO:0002252 UBERON:0005436 {source="FMA"} ! connecting branch of common hepatic artery property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "proper hepatic artery" xsd:string [Term] id: UBERON:0015481 name: left hepatic artery def: "A hepatic artery that is part of a left lobe of liver." [OBOL:automatic] subset: human_reference_atlas synonym: "left branch of hepatic artery" EXACT [FMA:14779] synonym: "left part of hepatic artery proper" EXACT [FMA:14779] synonym: "ramus sinister (arteria hepatica propria)" EXACT OMO:0003011 [FMA:14779, FMA:TA] xref: EMAPA:37096 {source="MA:th"} xref: FMA:14779 xref: MA:0003096 is_a: UBERON:0001193 ! hepatic artery is_a: UBERON:0015796 ! liver blood vessel intersection_of: UBERON:0001193 ! hepatic artery intersection_of: BFO:0000050 UBERON:0001115 ! part of left lobe of liver relationship: BFO:0000050 UBERON:0001115 {source="FMA"} ! part of left lobe of liver relationship: RO:0002170 UBERON:0015480 ! connected to proper hepatic artery property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "left hepatic artery" xsd:string [Term] id: UBERON:0015482 name: right hepatic artery def: "A hepatic artery that is part of a right lobe of liver." [OBOL:automatic] subset: human_reference_atlas synonym: "ramus dexter (arteria hepatica propria)" EXACT OMO:0003011 [FMA:14778, FMA:TA] synonym: "right branch of hepatic artery proper" EXACT [FMA:14778] synonym: "right part of hepatic artery proper" EXACT [FMA:14778] xref: EMAPA:37376 {source="MA:th"} xref: FMA:14778 xref: MA:0003097 is_a: UBERON:0001193 ! hepatic artery is_a: UBERON:0015796 ! liver blood vessel intersection_of: UBERON:0001193 ! hepatic artery intersection_of: BFO:0000050 UBERON:0001114 ! part of right lobe of liver relationship: BFO:0000050 UBERON:0001114 {source="FMA"} ! part of right lobe of liver relationship: RO:0002170 UBERON:0015480 ! connected to proper hepatic artery property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "right hepatic artery" xsd:string [Term] id: UBERON:0015485 name: choledocho-duodenal junction def: "Hat part of the duodenal wall traversed by the ductus choledochus, ductus pancreaticus, and ampulla." [http://medical-dictionary.thefreedictionary.com/choledochoduodenal+junction] synonym: "choledochoduodenal junction" EXACT [MA:0003108] xref: EMAPA:37478 {source="MA:th"} xref: MA:0003108 is_a: UBERON:1100000 ! digestive tract junction intersection_of: UBERON:0007651 ! anatomical junction intersection_of: RO:0002176 UBERON:0002114 ! connects duodenum intersection_of: RO:0002176 UBERON:0002394 ! connects bile duct relationship: RO:0002176 UBERON:0002114 ! connects duodenum relationship: RO:0002176 UBERON:0002394 ! connects bile duct property_value: skos:prefLabel "choledocho-duodenal junction" xsd:string [Term] id: UBERON:0015593 name: frontal gyrus def: "A gyrus that is part of a frontal cortex." [OBOL:automatic] xref: NCIT:C32636 xref: UMLS:C0228195 is_a: UBERON:0000200 ! gyrus intersection_of: UBERON:0000200 ! gyrus intersection_of: BFO:0000050 UBERON:0001870 ! part of frontal cortex relationship: BFO:0000050 UBERON:0001870 ! part of frontal cortex property_value: skos:prefLabel "frontal gyrus" xsd:string [Term] id: UBERON:0015599 name: genu of corpus callosum def: "Part of corpus callosum comprising the 'kneelike' anterior bend (adapted from Nolte, The Human Brain, 6th ed., 2009 pg 664)." [NLX:144462] synonym: "corpus callosum genu" EXACT [FMA:61946] synonym: "corpus callosum, genu" RELATED OMO:0003011 [NeuroNames:194] synonym: "genu" RELATED [NeuroNames:194] synonym: "genu corporis callosi" RELATED OMO:0003011 [NeuroNames:194] synonym: "genu corpus callosi" RELATED OMO:0003011 [NeuroNames:194] synonym: "genu of corpus callosum" RELATED [NeuroNames:194] synonym: "genu of the corpus callosum" RELATED [NeuroNames:194] synonym: "rostrum of corpus callosum (Mai)" RELATED [NeuroNames:194] xref: DHBA:10563 xref: FMA:61946 xref: HBA:9223 xref: MBA:1108 xref: NCIT:C32675 xref: neuronames:194 xref: NeuroNamesCNID:176 xref: NLX:144462 xref: SCTID:279310003 xref: UMLS:C0152321 xref: Wikipedia:Genu_of_the_corpus_callosum is_a: UBERON:0002616 ! regional part of brain relationship: BSPO:0000123 UBERON:0002336 ! corpus callosum property_value: skos:prefLabel "genu of corpus callosum" xsd:string [Term] id: UBERON:0015716 name: anal canal epithelium def: "An epithelium that is part of a anal canal." [OBOL:automatic] subset: human_reference_atlas synonym: "anal canal epithelium" EXACT [FMA:17511] synonym: "epithelium of anal canal" EXACT [FMA:17511] xref: EMAPA:18835 xref: FMA:17511 is_a: UBERON:0001278 ! epithelium of large intestine is_a: UBERON:0014703 ! anal membrane ectodermal component intersection_of: UBERON:0000483 ! epithelium intersection_of: BFO:0000050 UBERON:0000159 ! part of anal canal relationship: BFO:0000050 UBERON:0000159 ! part of anal canal property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "anal canal epithelium" xsd:string [Term] id: UBERON:0015717 name: smooth muscle tissue layer of ejaculatory duct def: "A smooth muscle tissue that is part of a ejaculatory duct." [OBOL:automatic] synonym: "muscle layer of ejaculatory duct" EXACT [FMA:19372] xref: EMAPA:32289 xref: FMA:19372 is_a: UBERON:0001135 ! smooth muscle tissue is_a: UBERON:0005156 ! reproductive structure intersection_of: UBERON:0001135 ! smooth muscle tissue intersection_of: BFO:0000050 UBERON:0000999 ! part of ejaculatory duct relationship: BFO:0000050 UBERON:0000999 ! part of ejaculatory duct [Term] id: UBERON:0015757 name: heterogeneous tissue synonym: "portion of heterogeneous tissue" EXACT [FMA:62798] xref: FMA:62798 is_a: UBERON:0000479 {source="FMA"} ! tissue [Term] id: UBERON:0015766 name: epithelium of duct of salivary gland def: "An epithelium that is part of a duct of salivary gland." [OBOL:automatic] synonym: "epithelium of salivary duct" EXACT [FMA:67682] synonym: "salivary duct epithelium" EXACT [FMA:67682] synonym: "salivary ductal epithelium" EXACT [FMA:67682] xref: FMA:67682 is_a: UBERON:0004809 ! salivary gland epithelium is_a: UBERON:0010371 {source="FMA"} ! ecto-epithelium is_a: UBERON:0034969 ! epithelial layer of duct intersection_of: UBERON:0000483 ! epithelium intersection_of: BFO:0000050 UBERON:0001837 ! part of duct of salivary gland relationship: BFO:0000050 UBERON:0001837 ! part of duct of salivary gland [Term] id: UBERON:0015783 name: smooth muscle layer in fatty layer of subcutaneous tissue def: "A smooth muscle tissue that is part of a hypodermis." [OBOL:automatic] synonym: "muscle layer in fatty layer of subcutaneous tissue" EXACT [FMA:77862] synonym: "stratum musculosum panniculi adiposi telae subcutaneae" EXACT OMO:0003011 [FMA:77862, FMA:TA] xref: FMA:77862 is_a: UBERON:0001135 ! smooth muscle tissue intersection_of: UBERON:0001135 ! smooth muscle tissue intersection_of: BFO:0000050 UBERON:0002072 ! part of hypodermis relationship: BFO:0000050 UBERON:0002072 ! part of hypodermis property_value: skos:prefLabel "smooth muscle layer in fatty layer of subcutaneous tissue" xsd:string [Term] id: UBERON:0015786 name: respiratory segment of nasal mucosa def: "The portion of the nasal mucosa that is part of the respiratory system." [http://orcid.org/0000-0002-6601-2165] synonym: "pars respiratoria tunicae mucosae nasi" EXACT OMO:0003011 [FMA:77198, FMA:TA] synonym: "respiratory zone of nasal mucosa" EXACT [FMA:77198] xref: FMA:77198 is_a: UBERON:0001826 ! nasal cavity mucosa intersection_of: UBERON:0001826 ! nasal cavity mucosa intersection_of: BFO:0000050 UBERON:0001004 ! part of respiratory system intersection_of: BFO:0000051 UBERON:0005385 ! has part nasal cavity respiratory epithelium relationship: BFO:0000051 UBERON:0005385 ! has part nasal cavity respiratory epithelium [Term] id: UBERON:0015787 name: upper respiratory conduit def: "Any anatomical conduit which is part of the upper respiratory tract." [http://orcid.org/0000-0002-6601-2165] synonym: "respiratory conduit" RELATED [FMA:265132] xref: FMA:265132 is_a: UBERON:0004111 ! anatomical conduit intersection_of: UBERON:0004111 ! anatomical conduit intersection_of: BFO:0000050 UBERON:0001557 ! part of upper respiratory tract relationship: BFO:0000050 UBERON:0001557 ! part of upper respiratory tract property_value: skos:prefLabel "upper respiratory conduit" xsd:string [Term] id: UBERON:0015788 name: olfactory apparatus chamber def: "An anatomical chamber that is part of the olfactory apparatus, consisting of cavity walls (nasal epithelium and mucosal layers) and the space bounded anteriorly by the nares and posteriorly by the choanae, when these structures are present." [http://orcid.org/0000-0002-6601-2165] xref: FMA:265136 is_a: UBERON:0015787 ! upper respiratory conduit relationship: BFO:0000050 UBERON:0000004 ! part of nose property_value: skos:prefLabel "olfactory apparatus chamber" xsd:string [Term] id: UBERON:0015789 name: cranial or facial muscle subset: grouping_class synonym: "cranial-facial muscle" RELATED [EMAPA:25133] synonym: "cranial/facial muscle" EXACT [MA:0000579] synonym: "cranio-facial muscle" RELATED [EMAPA:25133] synonym: "craniofacial muscle" RELATED [EMAPA:25133] xref: EMAPA:25133 xref: MA:0000579 is_a: UBERON:0002376 ! cranial muscle relationship: BFO:0000050 UBERON:0004473 ! part of musculature of face property_value: skos:prefLabel "cranial or facial muscle" xsd:string [Term] id: UBERON:0015790 name: autopod skin def: "A zone of skin that is part of a autopod region." [OBOL:automatic] synonym: "paw skin" RELATED [MA:0003120] xref: EMAPA:32723 xref: MA:0003120 is_a: UBERON:0001419 ! skin of limb intersection_of: UBERON:0000014 ! zone of skin intersection_of: BFO:0000050 UBERON:0002470 ! part of autopod region relationship: BFO:0000050 UBERON:0002470 ! part of autopod region [Term] id: UBERON:0015791 name: digit connective tissue def: "A portion of connective tissue that is part of a digit." [OBOL:automatic] xref: EMAPA:37290 {source="MA:th"} xref: MA:0003123 is_a: UBERON:0003587 ! limb connective tissue intersection_of: UBERON:0002384 ! connective tissue intersection_of: BFO:0000050 UBERON:0002544 ! part of digit relationship: BFO:0000050 UBERON:0002544 ! part of digit relationship: RO:0002494 UBERON:0010702 ! transformation of digit mesenchyme [Term] id: UBERON:0015794 name: left lung lobar bronchus epithelium def: "An epithelium that is part of a lobar bronchus of left lung." [OBOL:automatic] xref: EMAPA:17658 xref: MA:0003135 is_a: UBERON:0002339 ! epithelium of lobar bronchus is_a: UBERON:0003365 ! epithelium of left lung intersection_of: UBERON:0000483 ! epithelium intersection_of: BFO:0000050 UBERON:0003405 ! part of lobar bronchus of left lung relationship: BFO:0000050 UBERON:0003405 ! part of lobar bronchus of left lung [Term] id: UBERON:0015795 name: right lung lobar bronchus epitheium def: "An epithelium that is part of a lobar bronchus of right lung." [OBOL:automatic] xref: EMAPA:17666 xref: MA:0003136 is_a: UBERON:0002339 ! epithelium of lobar bronchus is_a: UBERON:0003364 ! epithelium of right lung intersection_of: UBERON:0000483 ! epithelium intersection_of: BFO:0000050 UBERON:0003404 ! part of lobar bronchus of right lung relationship: BFO:0000050 UBERON:0003404 ! part of lobar bronchus of right lung [Term] id: UBERON:0015796 name: liver blood vessel def: "A blood vessel that is part of a liver." [OBOL:automatic] synonym: "hepatic blood vessel" RELATED [EMAPA:35498] xref: EMAPA:35498 xref: MA:0003137 is_a: UBERON:0003497 ! abdomen blood vessel intersection_of: UBERON:0001981 ! blood vessel intersection_of: BFO:0000050 UBERON:0002107 ! part of liver relationship: BFO:0000050 UBERON:0002107 ! part of liver property_value: skos:prefLabel "liver blood vessel" xsd:string [Term] id: UBERON:0015807 name: ear epithelium def: "An epithelium that is part of a ear." [OBOL:automatic] xref: EMAPA:32800 xref: MA:0003161 is_a: UBERON:0019304 ! sensory organ epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: BFO:0000050 UBERON:0001690 ! part of ear relationship: BFO:0000050 UBERON:0001690 ! part of ear property_value: skos:prefLabel "ear epithelium" xsd:string [Term] id: UBERON:0015808 name: eye epithelium def: "An epithelium that is part of a camera-type eye." [OBOL:automatic] xref: EMAPA:35957 xref: MA:0003162 is_a: UBERON:0007625 ! pigment epithelium of eye intersection_of: UBERON:0000483 ! epithelium intersection_of: BFO:0000050 UBERON:0000019 ! part of camera-type eye relationship: BFO:0000050 UBERON:0000019 ! part of camera-type eye property_value: skos:prefLabel "eye epithelium" xsd:string [Term] id: UBERON:0015813 name: middle ear epithelium def: "An epithelium that is part of a middle ear." [OBOL:automatic] xref: EMAPA:35673 xref: MA:0003169 is_a: UBERON:0015807 ! ear epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: BFO:0000050 UBERON:0001756 ! part of middle ear relationship: BFO:0000050 UBERON:0001756 ! part of middle ear [Term] id: UBERON:0015814 name: outer ear epithelium def: "An epithelium that is part of a external ear." [OBOL:automatic] xref: EMAPA:35956 xref: MA:0003170 is_a: UBERON:0015807 ! ear epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: BFO:0000050 UBERON:0001691 ! part of external ear relationship: BFO:0000050 UBERON:0001691 ! part of external ear [Term] id: UBERON:0015833 name: foregut epithelium def: "An epithelium that is part of a foregut." [OBOL:automatic] xref: EMAPA:32922 xref: MA:0003204 is_a: UBERON:0003929 ! digestive tract epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: BFO:0000050 UBERON:0001041 ! part of foregut relationship: BFO:0000050 UBERON:0001041 ! part of foregut property_value: skos:prefLabel "foregut epithelium" xsd:string [Term] id: UBERON:0015834 name: duodenum lamina propria def: "A lamina propria that is part of a duodenum." [OBOL:automatic] subset: human_reference_atlas synonym: "duodenal lamina propria" EXACT [FMA:15972] synonym: "lamina propria mucosae of duodenum" EXACT [FMA:15972] synonym: "lamina propria of duodenum" EXACT [FMA:15972] xref: EMAPA:27255 xref: FMA:15972 xref: MA:0003209 is_a: UBERON:0001238 ! lamina propria of small intestine intersection_of: UBERON:0000030 ! lamina propria intersection_of: BFO:0000050 UBERON:0002114 ! part of duodenum relationship: BFO:0000050 UBERON:0008342 {source="FMA"} ! part of intestinal villus of duodenum property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "duodenum lamina propria" xsd:string [Term] id: UBERON:0015860 name: visceral abdominal lymph node xref: FMA:66178 is_a: UBERON:0002507 {source="FMA"} ! abdominal lymph node [Term] id: UBERON:0015870 name: lymph node of head def: "A lymph node that is part of a head." [OBOL:automatic] xref: FMA:61212 xref: SCTID:155136006 is_a: UBERON:0000029 ! lymph node intersection_of: UBERON:0000029 ! lymph node intersection_of: BFO:0000050 UBERON:0000033 ! part of head relationship: BFO:0000050 UBERON:0000033 ! part of head [Term] id: UBERON:0015871 name: facial lymph node def: "Any of the lymph nodes that are part of a face." [http://www.bartleby.com/107/177.html, Wikipedia:Facial_lymph_nodes] synonym: "buccal lymph node" EXACT [FMA:61222] xref: FMA:61222 xref: SCTID:279139005 xref: Wikipedia:Facial_lymph_nodes is_a: UBERON:0015870 ! lymph node of head intersection_of: UBERON:0000029 ! lymph node intersection_of: BFO:0000050 UBERON:0001456 ! part of face relationship: BFO:0000050 UBERON:0001456 ! part of face [Term] id: UBERON:0015917 name: superficial lymph node def: "A lymph node that is located close to the surface." [http://orcid.org/0000-0002-6601-2165] xref: FMA:12767 xref: NCIT:C102716 is_a: UBERON:0000029 ! lymph node intersection_of: UBERON:0000029 ! lymph node intersection_of: BFO:0000050 UBERON:0035549 ! part of vasculature of integument relationship: BFO:0000050 UBERON:0035549 ! part of vasculature of integument [Term] id: UBERON:0015918 name: deep lymph node def: "A lymph node that is located deeper within the organism, further from the surface." [http://orcid.org/0000-0002-6601-2165] xref: FMA:12768 is_a: UBERON:0000029 ! lymph node intersection_of: UBERON:0000029 ! lymph node intersection_of: BFO:0000050 UBERON:0035551 ! part of deep vasculature relationship: BFO:0000050 UBERON:0035551 ! part of deep vasculature [Term] id: UBERON:0016398 name: lymph node of lower limb def: "A lymph node that is part of a hindlimb." [OBOL:automatic] xref: FMA:44310 xref: SCTID:361109000 is_a: UBERON:0000029 ! lymph node intersection_of: UBERON:0000029 ! lymph node intersection_of: BFO:0000050 UBERON:0002103 ! part of hindlimb relationship: BFO:0000050 UBERON:0002103 ! part of hindlimb [Term] id: UBERON:0016399 name: lymph node of upper limb def: "A lymph node that is part of a forelimb." [OBOL:automatic] xref: FMA:44311 xref: SCTID:276155004 is_a: UBERON:0000029 ! lymph node intersection_of: UBERON:0000029 ! lymph node intersection_of: BFO:0000050 UBERON:0002102 ! part of forelimb relationship: BFO:0000050 UBERON:0002102 ! part of forelimb [Term] id: UBERON:0016405 name: pulmonary capillary def: "A capillary that is part of a lung." [OBOL:automatic] subset: human_reference_atlas subset: pheno_slim synonym: "capillary of lung" EXACT [FMA:14121] xref: FMA:14121 is_a: UBERON:0003512 ! lung blood vessel is_a: UBERON:0003526 ! respiratory system capillary intersection_of: UBERON:0001982 ! capillary intersection_of: BFO:0000050 UBERON:0002048 ! part of lung property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "pulmonary capillary" xsd:string [Term] id: UBERON:0016410 name: male breast def: "A breast that is part of a male organism." [OBOL:automatic] subset: pheno_slim synonym: "mamma masculina" EXACT [FMA:19901] xref: FMA:19901 xref: NCIT:C33048 xref: UMLS:C0222604 is_a: UBERON:0000310 ! breast intersection_of: UBERON:0000310 ! breast intersection_of: BFO:0000050 UBERON:0003101 ! part of male organism relationship: BFO:0000050 UBERON:0003101 ! part of male organism [Term] id: UBERON:0016413 name: medullary cavity of long bone subset: pheno_slim synonym: "central medullary cavity of long bone" RELATED [FMA:24023] xref: FMA:24023 is_a: UBERON:0002484 ! bone marrow cavity intersection_of: UBERON:0002484 ! bone marrow cavity intersection_of: BFO:0000050 UBERON:0002495 ! part of long bone relationship: BFO:0000050 UBERON:0002495 ! part of long bone [Term] id: UBERON:0016422 name: compact bone of long bone def: "A compact bone tissue that is part of a bone tissue of long bone." [OBOL:automatic] subset: pheno_slim xref: FMA:32674 is_a: UBERON:0001439 ! compact bone tissue is_a: UBERON:0005808 ! bone tissue of long bone intersection_of: UBERON:0001439 ! compact bone tissue intersection_of: BFO:0000050 UBERON:0005808 ! part of bone tissue of long bone relationship: BFO:0000050 UBERON:0005808 ! part of bone tissue of long bone [Term] id: UBERON:0016423 name: compact bone of diaphysis def: "A compact bone tissue that is part of a diaphysis." [OBOL:automatic] subset: pheno_slim xref: FMA:32678 is_a: UBERON:0001439 ! compact bone tissue is_a: UBERON:0005808 ! bone tissue of long bone intersection_of: UBERON:0001439 ! compact bone tissue intersection_of: BFO:0000050 UBERON:0004769 ! part of diaphysis relationship: BFO:0000050 UBERON:0004769 ! part of diaphysis [Term] id: UBERON:0016435 name: chest wall def: "Subdivision of thorax which includes all structures from the skin to the costal pleura. Examples: There is only one chest wall." [FMA:50060] subset: pheno_slim xref: EMAPA:37233 {source="MA:th"} xref: FMA:50060 xref: MESH:D035441 {sssom:mapping_justification="https://w3id.org/semapv/vocab/LexicalMatching"} xref: NCIT:C62484 xref: SCTID:181608004 is_a: UBERON:0000060 ! anatomical wall intersection_of: UBERON:0000060 ! anatomical wall intersection_of: BFO:0000050 UBERON:0001443 ! part of chest relationship: BFO:0000050 UBERON:0001443 ! part of chest [Term] id: UBERON:0016446 name: hair of head def: "A strand of hair that is part of a head." [OBOL:automatic] subset: pheno_slim synonym: "hair of scalp" NARROW [FMA:54241] synonym: "head hair" EXACT [FMA:54241] xref: FMA:54241 is_a: UBERON:0001037 ! strand of hair intersection_of: UBERON:0001037 ! strand of hair intersection_of: BFO:0000050 UBERON:0000033 ! part of head relationship: BFO:0000050 UBERON:0000033 ! part of head [Term] id: UBERON:0016447 name: hair of trunk def: "A strand of hair that is part of a trunk." [OBOL:automatic] subset: pheno_slim synonym: "trunk hair" EXACT [FMA:54250] xref: FMA:54250 is_a: UBERON:0001037 ! strand of hair intersection_of: UBERON:0001037 ! strand of hair intersection_of: BFO:0000050 UBERON:0002100 ! part of trunk relationship: BFO:0000050 UBERON:0002100 ! part of trunk [Term] id: UBERON:0016458 name: esophageal hiatus def: "A hole in the diaphragm through which the esophagus passes." [HP:0002036] subset: pheno_slim synonym: "esophageal hiatus of diaphragm" EXACT [FMA:58289] synonym: "oesophageal aperture" EXACT [FMA:58289] synonym: "oesophageal hiatus" EXACT [FMA:58289] xref: FMA:58289 is_a: UBERON:0000161 ! orifice intersection_of: UBERON:0000161 ! orifice intersection_of: BFO:0000050 UBERON:0001103 ! part of diaphragm intersection_of: RO:0002570 UBERON:0001043 ! conduit for esophagus relationship: BFO:0000050 UBERON:0001103 ! part of diaphragm relationship: RO:0002570 UBERON:0001043 ! conduit for esophagus property_value: skos:prefLabel "esophageal hiatus" xsd:string [Term] id: UBERON:0016478 name: liver stroma def: "A stroma that is part of a liver." [OBOL:automatic] subset: human_reference_atlas synonym: "hepatic stroma" EXACT [FMA:17553] synonym: "stroma of liver" EXACT [FMA:17553] xref: FMA:17553 is_a: UBERON:0003891 ! stroma intersection_of: UBERON:0003891 ! stroma intersection_of: BFO:0000050 UBERON:0002107 ! part of liver relationship: BFO:0000050 UBERON:0002107 ! part of liver property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0016479 name: capsule of liver def: "A collagenous capsule covering the external surface of the liver." [Wikipedia:Fibrous_capsule_of_Glisson] synonym: "capsula fibrosa perivascularis" EXACT OMO:0003011 [Wikipedia:Fibrous_capsule_of_Glisson] synonym: "fibrous capsule of Glisson" RELATED [Wikipedia:Fibrous_capsule_of_Glisson] synonym: "fibrous capsule of liver" EXACT [FMA:15813] synonym: "glisson's capsule" EXACT [FMA:15813] synonym: "hepatic capsule" EXACT [FMA:15813] synonym: "liver capsule" RELATED [Wikipedia:Fibrous_capsule_of_Glisson] synonym: "tunica fibrosa (hepar)" EXACT [FMA:TA] synonym: "tunica fibrosa hepatis" EXACT OMO:0003011 [FMA:15813, FMA:TA] xref: FMA:15813 xref: SCTID:362185005 xref: Wikipedia:Fibrous_capsule_of_Glisson is_a: UBERON:0003893 ! capsule intersection_of: UBERON:0003893 ! capsule intersection_of: RO:0002007 UBERON:0002107 ! bounding layer of liver relationship: RO:0002007 UBERON:0002107 ! bounding layer of liver relationship: RO:0002473 UBERON:0018135 ! composed primarily of fibrocollagenous connective tissue property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/liver-female/v1.2/assets/3d-vh-f-liver.glb" xsd:anyURI property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/liver-male/v1.2/assets/3d-vh-m-liver.glb" xsd:anyURI [Term] id: UBERON:0016481 name: bronchial lymph node def: "A lymph node that is part of a bronchus." [OBOL:automatic] xref: MA:0003078 xref: NCIT:C32232 xref: UMLS:C1305372 is_a: UBERON:0000029 ! lymph node intersection_of: UBERON:0000029 ! lymph node intersection_of: BFO:0000050 UBERON:0002185 ! part of bronchus relationship: BFO:0000050 UBERON:0002185 ! part of bronchus [Term] id: UBERON:0016490 name: auditory system def: "Is the sensory system for the sense of hearing." [NLXANAT:090817] xref: EMAPA:36002 xref: FMA:7192 xref: MA:0002443 xref: NCIT:C12889 xref: neuronames:2888 xref: NLXANAT:090817 xref: UMLS:C0587901 {source="ncithesaurus:Auditory_System"} xref: Wikipedia:Auditory_system is_a: UBERON:0007037 ! mechanosensory system intersection_of: UBERON:0001032 ! sensory system intersection_of: RO:0002215 GO:0007605 ! capable of sensory perception of sound relationship: BFO:0000050 UBERON:0002105 ! part of vestibulo-auditory system relationship: RO:0002215 GO:0007605 ! capable of sensory perception of sound property_value: skos:prefLabel "auditory system" xsd:string [Term] id: UBERON:0016491 name: vertebral centrum element def: "Skeletal element that functionally replaces the notochord[VSAP,modified]." [http://orcid.org/0000-0002-6601-2165, https://github.com/obophenotype/uberon/issues/207, https://github.com/obophenotype/uberon/issues/80, VSAO:0000183, VSAO:curator] synonym: "centrum" BROAD [VSAO:0000183] synonym: "centrum of vertebra" EXACT [] xref: VSAO:0000183 is_a: UBERON:0004765 {source="VSAO"} ! skeletal element relationship: BFO:0000050 UBERON:0010913 {source="VSAO"} ! part of vertebral element property_value: terms:contributor https://orcid.org/0000-0002-6601-2165 [Term] id: UBERON:0016500 name: muscularis mucosa of fundus of urinary bladder def: "A muscularis mucosa that is part of a fundus of urinary bladder." [OBOL:automatic] subset: human_reference_atlas xref: EMAPA:28625 is_a: UBERON:0006912 ! urinary bladder muscularis mucosa intersection_of: UBERON:0006676 ! muscularis mucosa intersection_of: BFO:0000050 UBERON:0006082 ! part of fundus of urinary bladder relationship: BFO:0000050 UBERON:0006082 ! part of fundus of urinary bladder relationship: BFO:0000050 UBERON:0006912 {source="EMAPA"} ! part of urinary bladder muscularis mucosa property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0016501 name: muscularis mucosae of fundus of stomach def: "A muscularis mucosa that is part of a fundus of stomach." [OBOL:automatic] xref: EMAPA:27165 xref: FMA:17278 is_a: UBERON:0001203 ! muscularis mucosae of stomach intersection_of: UBERON:0006676 ! muscularis mucosa intersection_of: BFO:0000050 UBERON:0001160 ! part of fundus of stomach relationship: BFO:0000050 UBERON:0001203 {source="FMA"} ! part of muscularis mucosae of stomach relationship: BFO:0000050 UBERON:0004994 {source="FMA"} ! part of mucosa of fundus of stomach [Term] id: UBERON:0016502 name: stomach fundus lumen def: "An anatomical space that is enclosed by a fundus of stomach." [OBOL:automatic] synonym: "cavity of fundus of stomach" EXACT [FMA:17077] synonym: "lumen of fundus of stomach" EXACT [FMA:17077] synonym: "lumen of stomach fundus" EXACT [] xref: EMAPA:18382 xref: FMA:17077 is_a: UBERON:0000464 ! anatomical space intersection_of: UBERON:0000464 ! anatomical space intersection_of: RO:0002572 UBERON:0001160 ! luminal space of fundus of stomach relationship: RO:0002572 UBERON:0001160 ! luminal space of fundus of stomach [Term] id: UBERON:0016508 name: pelvic ganglion subset: human_reference_atlas synonym: "inferior hypogastric ganglion" EXACT [FMA:80131] synonym: "pelvic ganglia" RELATED OMO:0003004 [] xref: EMAPA:31527 xref: FMA:80131 xref: SCTID:324760006 is_a: UBERON:0003964 {source="FMA"} ! prevertebral ganglion property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0016509 name: cavity of right ventricle def: "Luminal space of the right ventricle of the heart." [http://orcid.org/0000-0002-6601-2165] synonym: "right ventricle lumen" EXACT [EMAPA:26047] synonym: "right ventricular cavity" EXACT [FMA:FMA] xref: EMAPA:26047 xref: FMA:9291 is_a: UBERON:0035763 ! cavity of cardiac chamber intersection_of: UBERON:0002553 ! anatomical cavity intersection_of: RO:0002572 UBERON:0002080 ! luminal space of heart right ventricle relationship: RO:0002572 UBERON:0002080 ! luminal space of heart right ventricle property_value: skos:prefLabel "cavity of right ventricle" xsd:string [Term] id: UBERON:0016510 name: epithelium of male urethra def: "An epithelium that is part of a male urethra." [OBOL:automatic] synonym: "male urethral epithelium" EXACT [FMA:FMA] synonym: "urethral epithelium of male" EXACT [EMAPA:30467] xref: EMAPA:30467 xref: FMA:19684 is_a: UBERON:0002325 ! epithelium of urethra intersection_of: UBERON:0000483 ! epithelium intersection_of: BFO:0000050 UBERON:0001333 ! part of male urethra relationship: BFO:0000050 UBERON:0001333 ! part of male urethra [Term] id: UBERON:0016511 name: lamina propria of fundus of stomach def: "A lamina propria that is part of a mucosa of fundus of stomach." [OBOL:automatic] synonym: "lamina propria mucosae of fundus of stomach" EXACT [FMA:FMA] xref: EMAPA:27163 xref: FMA:17500 is_a: UBERON:8600138 ! stomach lamina propria intersection_of: UBERON:0000030 ! lamina propria intersection_of: BFO:0000050 UBERON:0004994 ! part of mucosa of fundus of stomach relationship: BFO:0000050 UBERON:0004994 ! part of mucosa of fundus of stomach [Term] id: UBERON:0016512 name: lumen of duodenum def: "An anatomical space that is part of a duodenum." [OBOL:automatic] synonym: "doudenal lumen" EXACT [FMA:FMA] synonym: "duodenal lumen" EXACT [FMA:FMA] xref: EMAPA:19080 xref: FMA:14589 is_a: UBERON:0000464 ! anatomical space intersection_of: UBERON:0000464 ! anatomical space intersection_of: BFO:0000050 UBERON:0002114 ! part of duodenum relationship: BFO:0000050 UBERON:0002114 ! part of duodenum property_value: skos:prefLabel "lumen of duodenum" xsd:string [Term] id: UBERON:0016513 name: cavity of left atrium def: "Luminal space of the left atrium of the heart." [http://orcid.org/0000-0002-6601-2165] synonym: "left atrial cavity" EXACT [FMA:FMA] synonym: "left atrium lumen" EXACT [EMAPA:26011] xref: EMAPA:26011 xref: FMA:9465 is_a: UBERON:0035763 ! cavity of cardiac chamber intersection_of: UBERON:0002553 ! anatomical cavity intersection_of: RO:0002572 UBERON:0002079 ! luminal space of left cardiac atrium relationship: RO:0002572 UBERON:0002079 ! luminal space of left cardiac atrium property_value: skos:prefLabel "cavity of left atrium" xsd:string [Term] id: UBERON:0016514 name: cavity of left ventricle def: "Luminal space of the left ventricle of the heart." [http://orcid.org/0000-0002-6601-2165] synonym: "left ventricular cavity" EXACT [FMA:FMA] xref: EMAPA:26038 xref: FMA:9466 is_a: UBERON:0035763 ! cavity of cardiac chamber intersection_of: UBERON:0002553 ! anatomical cavity intersection_of: RO:0002572 UBERON:0002084 ! luminal space of heart left ventricle relationship: RO:0002572 UBERON:0002084 ! luminal space of heart left ventricle property_value: skos:prefLabel "cavity of left ventricle" xsd:string [Term] id: UBERON:0016515 name: muscular layer of prostatic urethra def: "A muscular coat that is part of a prostatic urethra." [OBOL:automatic] synonym: "muscle layer of prostatic part of urethra" EXACT [FMA:FMA] synonym: "muscle layer of prostatic urethra" EXACT [EMAPA:30956, FMA:FMA] synonym: "muscular coat of prostatic urethra" EXACT [FMA:FMA] xref: EMAPA:30956 xref: FMA:19699 is_a: UBERON:0006660 ! muscular coat intersection_of: UBERON:0006660 ! muscular coat intersection_of: BFO:0000050 UBERON:0001335 ! part of prostatic urethra relationship: BFO:0000050 UBERON:0001335 ! part of prostatic urethra [Term] id: UBERON:0016516 name: lamina propria of prostatic urethra def: "A lamina propria that is part of a prostatic urethra." [OBOL:automatic] synonym: "lamina propria of prostatic part of urethra" EXACT [FMA:FMA] synonym: "lamina propria of prostatic urethra" EXACT [EMAPA:32303] xref: EMAPA:32303 xref: FMA:19693 is_a: UBERON:0002326 ! lamina propria of urethra intersection_of: UBERON:0000030 ! lamina propria intersection_of: BFO:0000050 UBERON:0001335 ! part of prostatic urethra relationship: BFO:0000050 UBERON:0001335 ! part of prostatic urethra [Term] id: UBERON:0016517 name: lumen of jejunum def: "An anatomical space that is part of a jejunum." [OBOL:automatic] synonym: "jejunal lumen" EXACT [FMA:FMA] synonym: "jejunum lumen" EXACT [FMA:FMA] xref: EMAPA:18729 xref: FMA:14590 is_a: UBERON:0000464 ! anatomical space intersection_of: UBERON:0000464 ! anatomical space intersection_of: BFO:0000050 UBERON:0002115 ! part of jejunum relationship: BFO:0000050 UBERON:0002115 ! part of jejunum [Term] id: UBERON:0016519 name: muscularis mucosae of jejunum def: "A muscularis mucosa that is part of a jejunum." [OBOL:automatic] subset: human_reference_atlas xref: EMAPA:27121 xref: FMA:15063 is_a: UBERON:0001210 ! muscularis mucosae of small intestine intersection_of: UBERON:0006676 ! muscularis mucosa intersection_of: BFO:0000050 UBERON:0002115 ! part of jejunum relationship: BFO:0000050 UBERON:0000399 {source="FMA"} ! part of jejunal mucosa property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0016520 name: epithelium of female urethra def: "An epithelium that is part of a female urethra." [OBOL:automatic] synonym: "female urethral epithelium" EXACT [FMA:FMA] synonym: "urethral epithelium of female" EXACT [EMAPA:30470] xref: EMAPA:30470 xref: FMA:19774 is_a: UBERON:0002325 ! epithelium of urethra intersection_of: UBERON:0000483 ! epithelium intersection_of: BFO:0000050 UBERON:0001334 ! part of female urethra relationship: BFO:0000050 UBERON:0001334 ! part of female urethra [Term] id: UBERON:0016522 name: cavity of right atrium def: "Luminal space of the right atrium of the heart." [http://orcid.org/0000-0002-6601-2165] synonym: "right atrial cavity" EXACT [FMA:FMA] xref: EMAPA:26020 xref: FMA:11359 is_a: UBERON:0035763 ! cavity of cardiac chamber intersection_of: UBERON:0002553 ! anatomical cavity intersection_of: RO:0002572 UBERON:0002078 ! luminal space of right cardiac atrium relationship: RO:0002572 UBERON:0002078 ! luminal space of right cardiac atrium property_value: skos:prefLabel "cavity of right atrium" xsd:string [Term] id: UBERON:0016525 name: frontal lobe def: "Frontal lobe is the anterior-most of five lobes of the cerebral hemisphere. It is bounded by the central sulcus on its posterior border and by the longitudinal cerebral fissure on its medial border." [FMA:61824] subset: efo_slim subset: human_reference_atlas synonym: "frontal cortex" NARROW [FMA:61824] synonym: "frontal region" BROAD [FMA:61824] synonym: "lobi frontales" EXACT OMO:0003011 [NeuroNames:56] synonym: "lobus frontalis" EXACT OMO:0003011 [Wikipedia:Frontal_lobe] synonym: "regio frontalis" BROAD OMO:0003011 [FMA:61824, FMA:TA] xref: BAMS:Frontal_lobe xref: BIRNLEX:928 xref: BM:Tel-Cx-FR xref: CALOHA:TS-0389 xref: DHBA:12113 xref: EFO:0000913 xref: EV:0100167 xref: FMA:61824 xref: HBA:4009 xref: MAT:0000505 xref: MESH:D005625 xref: NCIT:C12352 xref: neuronames:56 {source="BIRNLEX:928"} xref: SCTID:180920004 xref: UMLS:C0016733 {source="BIRNLEX:928", source="ncithesaurus:Frontal_Lobe"} xref: UMLS:C1268977 {source="BIRNLEX:928"} is_a: UBERON:0016526 {source="FMA"} ! lobe of cerebral hemisphere relationship: RO:0002220 UBERON:0001871 ! adjacent to temporal lobe relationship: RO:0002220 UBERON:0001872 ! adjacent to parietal lobe relationship: RO:0002433 UBERON:0001893 ! contributes to morphology of telencephalon property_value: IAO:0000116 "Many species don't have lobes but they do have frontal cortex. Lobe isn't a really well defined term though" xsd:string {source="MM"} property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "frontal lobe" xsd:string [Term] id: UBERON:0016526 name: lobe of cerebral hemisphere def: "Subdivision of telencephalon which is one of a number of subdivisions of each hemisphere separated by both real landmarks (sulci and fissures) and arbitrary boundaries[FMA,modified]." [FMA:61823] comment: We use the term lobe broadly as a rough regional area, encompassing homologous regions in smooth-brained mammals. We subdivide the lobes into white matter and neocortical parts. synonym: "cerebral cortical segment" RELATED [FMA:68603] synonym: "cerebral hemisphere lobe" EXACT [FMA:61823] synonym: "cerebral lobe" EXACT [BTO:0000445] synonym: "lobe of cerebral cortex" EXACT [BIRNLEX:922] synonym: "lobe parts of cerebral cortex" EXACT [BIRNLEX:922] synonym: "lobes of the brain" RELATED [BIRNLEX:922] synonym: "lobi cerebri" EXACT OMO:0003011 [FMA:77800, FMA:TA] synonym: "regional organ part of cerebral cortex" RELATED [FMA:68603] synonym: "segment of cerebral cortex" RELATED [BIRNLEX:922] xref: BIRNLEX:922 xref: BTO:0000445 xref: FMA:61823 xref: neuronames:1210 xref: SCTID:272632001 is_a: UBERON:0000064 ! organ part relationship: BFO:0000050 UBERON:0001869 ! part of cerebral hemisphere property_value: skos:prefLabel "lobe of cerebral hemisphere" xsd:string [Term] id: UBERON:0016527 name: white matter of cerebral lobe xref: FMA:256176 is_a: UBERON:0002437 ! cerebral hemisphere white matter intersection_of: UBERON:0002437 ! cerebral hemisphere white matter intersection_of: BFO:0000050 UBERON:0016526 ! part of lobe of cerebral hemisphere relationship: BFO:0000050 UBERON:0016526 ! part of lobe of cerebral hemisphere relationship: BSPO:0000107 UBERON:0016529 ! cortex of cerebral lobe property_value: skos:prefLabel "white matter of cerebral lobe" xsd:string [Term] id: UBERON:0016528 name: white matter of frontal lobe def: "A white matter of cerebral lobe that is part of a frontal lobe." [OBOL:automatic] synonym: "frontal lobe white matter" EXACT [] xref: FMA:256178 xref: SCTID:362331002 is_a: UBERON:0016527 ! white matter of cerebral lobe intersection_of: UBERON:0016527 ! white matter of cerebral lobe intersection_of: BFO:0000050 UBERON:0016525 ! part of frontal lobe relationship: BFO:0000050 UBERON:0016525 ! part of frontal lobe property_value: skos:prefLabel "white matter of frontal lobe" xsd:string [Term] id: UBERON:0016529 name: cortex of cerebral lobe def: "Grey matter neocortex region of a lobe of the cerebral hemisphere." [http://orcid.org/0000-0002-6601-2165] synonym: "cortex of cerebral hemisphere lobe" EXACT [FMA:242197] synonym: "cortex of lobe of cerebral hemisphere" EXACT [FMA:242197] synonym: "gray matter of lobe of cerebral hemisphere" RELATED [FMA:242197] synonym: "neocortical part of cerebral hemisphere" RELATED [] xref: FMA:242197 is_a: UBERON:0005401 ! cerebral hemisphere gray matter intersection_of: UBERON:0005401 ! cerebral hemisphere gray matter intersection_of: BFO:0000050 UBERON:0001950 ! part of neocortex intersection_of: BFO:0000050 UBERON:0016526 ! part of lobe of cerebral hemisphere relationship: BFO:0000050 UBERON:0001950 ! part of neocortex relationship: BFO:0000050 UBERON:0016526 ! part of lobe of cerebral hemisphere property_value: skos:prefLabel "cortex of cerebral lobe" xsd:string [Term] id: UBERON:0016530 name: parietal cortex def: "Gray matter of the parietal region of the neocortex, located in the parietal lobe of gyrencephalic animals. It is continuous anteriorly with the frontal cortex, posteriorly with the occipital cortex and medially with the insular cortex and with the temporal cortex on the posterior/inferior border." [NLX:79282] subset: pheno_slim synonym: "cortex of parietal lobe" EXACT [FMA:242203] synonym: "gray matter of parietal lobe" RELATED [FMA:242203] synonym: "parietal lobe cortex" EXACT [FMA:242203] synonym: "parietal neocortex" EXACT [DHBA:10208] xref: DHBA:10208 xref: DMBA:16016 xref: EMAPA:35667 xref: FMA:242203 xref: MA:0000916 xref: MESH:D010296 {sssom:mapping_justification="https://w3id.org/semapv/vocab/LexicalMatching"} xref: neuronames:2473 xref: NLX:79282 xref: SCTID:369217001 is_a: UBERON:0016529 ! cortex of cerebral lobe intersection_of: UBERON:0016529 ! cortex of cerebral lobe intersection_of: BFO:0000050 UBERON:0001872 ! part of parietal lobe relationship: BFO:0000050 UBERON:0001872 ! part of parietal lobe property_value: skos:prefLabel "parietal cortex" xsd:string [Term] id: UBERON:0016531 name: white matter of parietal lobe def: "A white matter of cerebral lobe that is part of a parietal lobe." [OBOL:automatic] xref: FMA:256184 xref: SCTID:369200008 is_a: UBERON:0016527 ! white matter of cerebral lobe intersection_of: UBERON:0016527 ! white matter of cerebral lobe intersection_of: BFO:0000050 UBERON:0001872 ! part of parietal lobe relationship: BFO:0000050 UBERON:0001872 ! part of parietal lobe property_value: skos:prefLabel "white matter of parietal lobe" xsd:string [Term] id: UBERON:0016534 name: white matter of temporal lobe def: "A white matter of cerebral lobe that is part of a temporal lobe." [OBOL:automatic] xref: FMA:256186 xref: SCTID:362344007 is_a: UBERON:0016527 ! white matter of cerebral lobe intersection_of: UBERON:0016527 ! white matter of cerebral lobe intersection_of: BFO:0000050 UBERON:0001871 ! part of temporal lobe relationship: BFO:0000050 UBERON:0001871 ! part of temporal lobe property_value: skos:prefLabel "white matter of temporal lobe" xsd:string [Term] id: UBERON:0016536 name: white matter of limbic lobe def: "A white matter of cerebral lobe that is part of a limbic lobe." [OBOL:automatic] xref: FMA:261091 is_a: UBERON:0016527 ! white matter of cerebral lobe intersection_of: UBERON:0016527 ! white matter of cerebral lobe intersection_of: BFO:0000050 UBERON:0002600 ! part of limbic lobe relationship: BFO:0000050 UBERON:0002600 ! part of limbic lobe property_value: skos:prefLabel "white matter of limbic lobe" xsd:string [Term] id: UBERON:0016538 name: temporal cortex def: "Gray matter of the temporal region of the neocortex, located in the temporal lobe in gyrencephalic animals." [NLX:94939] synonym: "cortex of temporal lobe" EXACT [FMA:242201] synonym: "gray matter of temporal lobe" RELATED [FMA:242201] synonym: "temporal lobe cortex" EXACT [FMA:242201] synonym: "temporal neocortex" EXACT [DHBA:10235] xref: BM:Tel-Cx-Te xref: DHBA:10235 xref: DMBA:16044 xref: FMA:242201 xref: MA:0000941 xref: MESH:D013702 {sssom:mapping_justification="https://w3id.org/semapv/vocab/LexicalMatching"} xref: NLX:94939 xref: SCTID:362343001 is_a: UBERON:0016529 ! cortex of cerebral lobe intersection_of: UBERON:0016529 ! cortex of cerebral lobe intersection_of: BFO:0000050 UBERON:0001871 ! part of temporal lobe relationship: BFO:0000050 UBERON:0001871 ! part of temporal lobe property_value: skos:prefLabel "temporal cortex" xsd:string [Term] id: UBERON:0016542 name: limbic cortex synonym: "cortex of limbic lobe" EXACT [FMA:242234] synonym: "gray matter of limbic lobe" RELATED [FMA:242234] synonym: "limbic lobe cortex" EXACT [FMA:242234] xref: FMA:242234 is_a: UBERON:0016529 ! cortex of cerebral lobe intersection_of: UBERON:0016529 ! cortex of cerebral lobe intersection_of: BFO:0000050 UBERON:0002600 ! part of limbic lobe relationship: BFO:0000050 UBERON:0002600 ! part of limbic lobe property_value: skos:prefLabel "limbic cortex" xsd:string [Term] id: UBERON:0016545 name: pharyngeal ectoderm def: "The external part of the developing pharynx that is made of ectoderm. During vertebrate development, pockets form in pharyngeal ectoderm between the pharyngeal arches." [http://orcid.org/0000-0002-6601-2165, PMID:23020903] xref: TAO:0001379 xref: ZFA:0001379 is_a: UBERON:0000490 ! unilaminar epithelium is_a: UBERON:0003351 ! pharyngeal epithelium is_a: UBERON:0005291 ! embryonic tissue intersection_of: UBERON:0000490 ! unilaminar epithelium intersection_of: BFO:0000050 UBERON:0000076 ! part of external ectoderm intersection_of: BFO:0000050 UBERON:0001042 ! part of chordate pharynx relationship: BFO:0000050 UBERON:0000076 ! part of external ectoderm property_value: skos:prefLabel "pharyngeal ectoderm" xsd:string [Term] id: UBERON:0016548 name: central nervous system gray matter layer def: "A layer of of the central nervous system that is part of gray matter." [http://orcid.org/0000-0002-6601-2165] synonym: "CNS gray matter layer" EXACT [] synonym: "CNS grey matter layer" EXACT [] synonym: "gray matter layer of neuraxis" EXACT [FMA:83142] synonym: "grey matter layer" BROAD [] synonym: "grey matter layer of neuraxis" EXACT [] xref: FMA:83142 is_a: UBERON:0022303 ! nervous system cell part layer intersection_of: UBERON:0022303 ! nervous system cell part layer intersection_of: RO:0002473 UBERON:0002020 ! composed primarily of gray matter relationship: RO:0002473 UBERON:0002020 ! composed primarily of gray matter property_value: skos:prefLabel "central nervous system gray matter layer" xsd:string [Term] id: UBERON:0016549 name: central nervous system white matter layer def: "A layer of of the central nervous system that is composed of white matter." [http://orcid.org/0000-0002-6601-2165] synonym: "CNS white matter layer" EXACT [] synonym: "white matter layer" BROAD [] synonym: "white matter layer of neuraxis" EXACT [FMA:83898] xref: FMA:83898 is_a: UBERON:0022303 ! nervous system cell part layer intersection_of: UBERON:0022303 ! nervous system cell part layer intersection_of: RO:0002473 UBERON:0002316 ! composed primarily of white matter relationship: RO:0002473 UBERON:0002316 ! composed primarily of white matter property_value: skos:prefLabel "central nervous system white matter layer" xsd:string [Term] id: UBERON:0016550 name: spinal cord column is_a: UBERON:0011215 ! central nervous system cell part cluster relationship: BFO:0000050 UBERON:0002240 ! part of spinal cord property_value: skos:prefLabel "spinal cord column" xsd:string [Term] id: UBERON:0016552 name: phlegm def: "Mucus produced in the respiratory tract." [http://orcid.org/0000-0002-6601-2165] xref: NCIT:C93171 xref: UMLS:C0225378 is_a: UBERON:0000912 ! mucus intersection_of: UBERON:0000912 ! mucus intersection_of: RO:0003001 UBERON:0000065 ! produced by respiratory tract relationship: RO:0003001 UBERON:0000065 ! produced by respiratory tract property_value: skos:prefLabel "phlegm" xsd:string [Term] id: UBERON:0016553 name: respiratory system mucus def: "Any mucus produced by a mucosae of the respiratory system. This includes the mucus produced in the nasal cavity (nasal mucus) and mucus produced in the respiratory tract (phlegm)." [http://orcid.org/0000-0002-6601-2165, Wikipedia:Nasal_mucus#Respiratory_system] is_a: UBERON:0000912 ! mucus intersection_of: UBERON:0000912 ! mucus intersection_of: RO:0003001 UBERON:0004785 ! produced by respiratory system mucosa relationship: RO:0003001 UBERON:0004785 ! produced by respiratory system mucosa property_value: skos:prefLabel "respiratory system mucus" xsd:string [Term] id: UBERON:0016554 name: white matter of midbrain def: "A white matter that is part of the midbrain." [OBOL:automatic] subset: human_reference_atlas synonym: "mesencephalic white matter" EXACT [HBA:MESWM] xref: DHBA:10650 xref: FMA:83936 xref: HBA:265505382 is_a: UBERON:0003544 ! brain white matter intersection_of: UBERON:0002316 ! white matter intersection_of: BFO:0000050 UBERON:0001891 ! part of midbrain relationship: BFO:0000050 UBERON:0001891 ! part of midbrain property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "white matter of midbrain" xsd:string [Term] id: UBERON:0016565 name: cerebral blood vessel def: "A blood vessel that is part of a cerebellum." [OBOL:automatic] is_a: UBERON:0003499 ! brain blood vessel intersection_of: UBERON:0001981 ! blood vessel intersection_of: BFO:0000050 UBERON:0002037 ! part of cerebellum relationship: BFO:0000050 UBERON:0002037 ! part of cerebellum property_value: skos:prefLabel "cerebral blood vessel" xsd:string [Term] id: UBERON:0016566 name: pit def: "An roughly circular indentation in a surface." [AEO:0000204, AEO:JB] subset: upper_level xref: AEO:0000204 is_a: UBERON:0036215 ! anatomical surface region property_value: skos:prefLabel "pit" xsd:string [Term] id: UBERON:0016570 name: lamina of gray matter of spinal cord synonym: "rexed lamina" EXACT [FMA:68861] xref: FMA:68861 xref: http://neurolex.org/wiki/Category\:Rexed_spinal_cord_parcellation_scheme_region xref: Wikipedia:Rexed_laminae is_a: UBERON:0011215 ! central nervous system cell part cluster is_a: UBERON:0022303 ! nervous system cell part layer intersection_of: UBERON:0022303 ! nervous system cell part layer intersection_of: BFO:0000050 UBERON:0002315 ! part of gray matter of spinal cord relationship: BFO:0000050 UBERON:0002315 ! part of gray matter of spinal cord property_value: skos:prefLabel "lamina of gray matter of spinal cord" xsd:string [Term] id: UBERON:0016611 name: auditory hillocks, pharyngeal arch 1 derived def: "A collection of protruberances derived from pharyngeal arch 1 that develop into the tragus, crus of the helix, and helix." [http://php.med.unsw.edu.au/embryology/index.php?title=Hearing_-_Outer_Ear_Development#Pinna-_Auricle] is_a: BFO:0000002 is_a: BFO:0000004 is_a: UBERON:0000477 ! anatomical cluster intersection_of: UBERON:0000477 ! anatomical cluster intersection_of: BFO:0000050 UBERON:0006208 ! part of auditory hillocks intersection_of: RO:0002202 UBERON:0004362 ! develops from pharyngeal arch 1 relationship: BFO:0000050 UBERON:0006208 ! part of auditory hillocks relationship: RO:0002202 UBERON:0004362 ! develops from pharyngeal arch 1 [Term] id: UBERON:0016612 name: auditory hillocks, pharyngeal arch 2 derived def: "A collection of protruberances derived from pharyngeal arch 2 that develop into the concha, antihelix and antitragus." [http://php.med.unsw.edu.au/embryology/index.php?title=Hearing_-_Outer_Ear_Development#Pinna-_Auricle] is_a: BFO:0000002 is_a: BFO:0000004 is_a: UBERON:0000477 ! anatomical cluster intersection_of: UBERON:0000477 ! anatomical cluster intersection_of: BFO:0000050 UBERON:0006208 ! part of auditory hillocks intersection_of: RO:0002202 UBERON:0003066 ! develops from pharyngeal arch 2 relationship: BFO:0000050 UBERON:0006208 ! part of auditory hillocks relationship: RO:0002202 UBERON:0003066 ! develops from pharyngeal arch 2 [Term] id: UBERON:0016634 name: premotor cortex def: "The premotor cortex is an area of motor cortex lying within the frontal lobe of the brain. It extends 3 mm anterior to the primary motor cortex, near the Sylvian fissure, before narrowing to approximately 1 mm near the medial longitudinal fissure, which serves as the posterior border for the prefrontal cortex. The premotor cortex is largely equivalent to Brodmann area 6. Activity within this region is critical to the sensory guidance of movement and control of proximal and trunk muscles of the body." [Wikipedia:Premotor_cortex] synonym: "intermediate precentral cortex" RELATED [NeuroNames:2331] synonym: "nonprimary motor cortex" RELATED [NeuroNames:2331] synonym: "premotor" RELATED [Wikipedia:Premotor_cortex] synonym: "premotor area" RELATED [NeuroNames:2331] synonym: "premotor cortex" RELATED [NeuroNames:2331] synonym: "premotor cortex (area 6)" EXACT [DHBA:10168] synonym: "premotor region" RELATED [Wikipedia:Premotor_cortex] synonym: "promotor cortex" RELATED [NeuroNames:2331] synonym: "secondary motor areas" RELATED [NeuroNames:2331] synonym: "secondary motor cortex" RELATED [NeuroNames:2331] synonym: "secondary somatomotor areas" RELATED [NeuroNames:2331] xref: DHBA:10168 xref: FMA:224852 xref: MBA:993 xref: neuronames:2331 xref: SCTID:90928005 xref: Wikipedia:Premotor_cortex is_a: UBERON:0002616 ! regional part of brain relationship: BFO:0000050 UBERON:0000956 ! part of cerebral cortex property_value: skos:prefLabel "premotor cortex" xsd:string [Term] id: UBERON:0016854 name: dorsal part of optic cup def: "The dorsal region of the optic cup that gives rise to the dorsal part of the retina." [http://orcid.org/0000-0002-6601-2165] synonym: "dorsal optic cup" EXACT [http://orcid.org/0000-0002-6601-2165] synonym: "dorsal region of optic cup" EXACT [http://orcid.org/0000-0002-6601-2165] is_a: UBERON:0000481 ! multi-tissue structure intersection_of: UBERON:0000481 ! multi-tissue structure intersection_of: BSPO:0015101 UBERON:0003072 ! optic cup relationship: BSPO:0015101 UBERON:0003072 ! optic cup property_value: skos:prefLabel "dorsal part of optic cup" xsd:string [Term] id: UBERON:0016855 name: ventral part of optic cup def: "The ventral region of the optic cup that gives rise to the ventral part of the retina." [http://orcid.org/0000-0002-6601-2165] comment: optic fissure, hyaloid artery, pecten synonym: "ventral optic cup" EXACT [http://orcid.org/0000-0002-6601-2165] synonym: "ventral region of optic cup" EXACT [http://orcid.org/0000-0002-6601-2165] is_a: UBERON:0000481 ! multi-tissue structure intersection_of: UBERON:0000481 ! multi-tissue structure intersection_of: BSPO:0015102 UBERON:0003072 ! optic cup relationship: BSPO:0015102 UBERON:0003072 ! optic cup property_value: skos:prefLabel "ventral part of optic cup" xsd:string [Term] id: UBERON:0016879 name: future central nervous system def: "Primordium that develops into the central nervous system." [http://orcid.org/0000-0002-6601-2165] synonym: "future CNS" EXACT [] synonym: "presumptive central nervous system" EXACT [] is_a: BFO:0000002 is_a: UBERON:0006598 ! presumptive structure intersection_of: UBERON:0006598 ! presumptive structure intersection_of: RO:0002387 UBERON:0001017 ! has potential to develop into central nervous system relationship: BFO:0000050 UBERON:0016880 ! part of future nervous system relationship: RO:0002202 UBERON:0000924 ! develops from ectoderm relationship: RO:0002387 UBERON:0001017 ! has potential to develop into central nervous system property_value: skos:prefLabel "future central nervous system" xsd:string [Term] id: UBERON:0016880 name: future nervous system def: "Primordium that develops into the nervous system." [http://orcid.org/0000-0002-6601-2165] synonym: "presumptive nervous system" EXACT [AAO:0000477] xref: AAO:0000477 is_a: UBERON:0006598 ! presumptive structure intersection_of: UBERON:0006598 ! presumptive structure intersection_of: RO:0002387 UBERON:0001016 ! has potential to develop into nervous system relationship: RO:0002387 UBERON:0001016 ! has potential to develop into nervous system relationship: RO:0002496 UBERON:0000111 ! existence starts during or after organogenesis stage property_value: skos:prefLabel "future nervous system" xsd:string [Term] id: UBERON:0016884 name: shoulder joint def: "The joint that is formed by the union of the humerus, the scapula (or shoulder blade), and the clavicle (or collarbone). Commonly thought of as a single joint, the shoulder is actually made up of two separate joints - the glenohumeral and acromioclavicular joints." [http://www.innerbody.com/image/skel17.html] synonym: "joint of shoulder region" EXACT [] xref: SCTID:361835002 is_a: BFO:0000002 is_a: UBERON:0000982 ! skeletal joint intersection_of: UBERON:0000982 ! skeletal joint intersection_of: BFO:0000050 UBERON:0001467 ! part of shoulder relationship: BFO:0000050 UBERON:0001467 ! part of shoulder relationship: RO:0002202 UBERON:0006292 {evidence="definitional"} ! develops from shoulder joint primordium [Term] id: UBERON:0016885 name: epithelium of terminal part of digestive tract def: "Epithelium lining the distalmost portion of the digestive tract." [http://orcid.org/0000-0002-6601-2165] synonym: "rectum epithelium" NARROW [BTO:0005445] xref: BTO:0005445 xref: WBbt:0005800 is_a: UBERON:0003929 ! digestive tract epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: BFO:0000050 UBERON:0006866 ! part of terminal part of digestive tract relationship: BFO:0000050 UBERON:0006866 ! part of terminal part of digestive tract property_value: skos:prefLabel "epithelium of terminal part of digestive tract" xsd:string [Term] id: UBERON:0016886 name: muscle tissue of terminal part of digestive tract def: "Any muscle tissue of the distalmost portion of the digestive tract." [http://orcid.org/0000-0002-6601-2165] synonym: "rectum muscle" NARROW [] synonym: "rectum muscle structure" NARROW [] is_a: UBERON:0002385 ! muscle tissue intersection_of: UBERON:0002385 ! muscle tissue intersection_of: BFO:0000050 UBERON:0006866 ! part of terminal part of digestive tract relationship: BFO:0000050 UBERON:0006866 ! part of terminal part of digestive tract property_value: skos:prefLabel "muscle tissue of terminal part of digestive tract" xsd:string [Term] id: UBERON:0016887 name: entire extraembryonic component def: "The part of the conceptus that may be lost before birth or will be discarded at birth, or when the embryo becomes an independent organism." [AEO:0000195, AEO:JB] synonym: "extra-embryonic component" EXACT [] synonym: "extraembryonic component" EXACT [AEO:0000195] xref: AEO:0000195 xref: EHDAA2:0000003 xref: EMAPA:16042 is_a: UBERON:0000481 {source="AEO"} ! multi-tissue structure relationship: BFO:0000050 UBERON:0004716 {source="AEO"} ! part of conceptus relationship: RO:0002220 UBERON:0002050 ! adjacent to embryonic structure relationship: RO:0002491 UBERON:0000068 ! existence starts and ends during embryo stage property_value: skos:prefLabel "entire extraembryonic component" xsd:string [Term] id: UBERON:0016888 name: transitional anatomical structure def: "An embryonic anatomical entity that will turn into one or more other anatomical entities, perhaps with other anatomical entities, later in development." [AEO:0000132, AEO:JB] xref: AEO:0000132 is_a: UBERON:0005423 {source="AEO"} ! developing anatomical structure property_value: skos:prefLabel "transitional anatomical structure" xsd:string [Term] id: UBERON:0016896 name: periosteum of long bone def: "A periosteum that is part of a long bone." [OBOL:automatic] synonym: "long bone periosteum" EXACT [FMA:32677] xref: FMA:32677 is_a: UBERON:0002515 ! periosteum intersection_of: UBERON:0002515 ! periosteum intersection_of: BFO:0000050 UBERON:0002495 ! part of long bone relationship: BFO:0000050 UBERON:0002495 ! part of long bone [Term] id: UBERON:0016928 name: metaphysis of fibula def: "A metaphysis that is part of a fibula." [UBERON:nv] synonym: "fibula metaphysis" EXACT [FMA:33745] synonym: "fibular metaphysis" EXACT [] xref: FMA:33745 is_a: UBERON:0001438 ! metaphysis intersection_of: UBERON:0001438 ! metaphysis intersection_of: BFO:0000050 UBERON:0001446 ! part of fibula relationship: BFO:0000050 UBERON:0001446 ! part of fibula [Term] id: UBERON:0017163 name: skin bony tubercle def: "A bony structure embedded in skin, roughly equivalent to osteoderms." [PHENOSCAPE:Nizar] synonym: "bony tubercle" BROAD [] synonym: "bony tubercles" RELATED OMO:0003004 [] is_a: BFO:0000002 is_a: UBERON:0005813 ! tubercle is_a: UBERON:0013703 ! integumentary projection intersection_of: UBERON:0005813 ! tubercle intersection_of: BFO:0000050 UBERON:0002199 ! part of integument intersection_of: RO:0002473 UBERON:0002481 ! composed primarily of bone tissue relationship: BFO:0000050 UBERON:0002199 ! part of integument relationship: RO:0002473 UBERON:0002481 ! composed primarily of bone tissue [Term] id: UBERON:0017261 name: intertarsal sesamoid def: "A sesamoid element that is part of a tarsal skeleton." [OBOL:automatic] synonym: "tarsal sesamoid" RELATED [] is_a: UBERON:0011141 ! appendicular ossicle is_a: UBERON:0013631 ! sesamoid element intersection_of: UBERON:0013631 ! sesamoid element intersection_of: BFO:0000050 UBERON:0009879 ! part of tarsal skeleton relationship: BFO:0000050 UBERON:0009879 ! part of tarsal skeleton [Term] id: UBERON:0017615 name: vomerine dentition def: "A set of teeth in which each tooth that attaches to a vomer." [OBOL:automatic] synonym: "vomerine teeth" RELATED [] is_a: UBERON:0003672 ! dentition is_a: UBERON:0010314 ! structure with developmental contribution from neural crest intersection_of: UBERON:0003672 ! dentition intersection_of: RO:0002371 UBERON:0002396 ! attached to vomer relationship: RO:0002371 UBERON:0002396 ! attached to vomer [Term] id: UBERON:0017635 name: paired venous dural sinus synonym: "paired dural venous sinus" EXACT [FMA:52568] xref: FMA:52568 is_a: UBERON:0003496 ! head blood vessel is_a: UBERON:0005486 ! venous dural sinus is_a: UBERON:0015212 ! lateral structure intersection_of: UBERON:0005486 ! venous dural sinus intersection_of: BSPO:0000126 UBERON:0000033 ! head relationship: BSPO:0000126 UBERON:0000033 ! head [Term] id: UBERON:0017648 name: ventral body wall def: "The ventral part of the body wall." [http://orcid.org/0000-0002-6601-2165] synonym: "anterior body wall" RELATED [FMA:86934] xref: EMAPA:37984 {source="MA:th"} xref: FMA:86934 is_a: UBERON:0000309 ! body wall intersection_of: UBERON:0000309 ! body wall intersection_of: BFO:0000050 UBERON:0013235 ! part of ventrum relationship: BFO:0000050 UBERON:0013235 ! part of ventrum [Term] id: UBERON:0017649 name: dorsal body wall def: "The dorsal part of the body wall." [http://orcid.org/0000-0002-6601-2165] is_a: UBERON:0000309 ! body wall intersection_of: UBERON:0000309 ! body wall intersection_of: BFO:0000050 UBERON:0001137 ! part of dorsum relationship: BFO:0000050 UBERON:0001137 ! part of dorsum [Term] id: UBERON:0017650 name: developing mesenchymal structure def: "A mesenchyme-derived anatomical entity undergoing a transtion to become another structure." [AEO:0001016, AEO:JB] xref: AEO:0001016 is_a: UBERON:0005423 ! developing anatomical structure intersection_of: UBERON:0005423 ! developing anatomical structure intersection_of: RO:0002473 UBERON:0003104 ! composed primarily of mesenchyme relationship: RO:0002473 UBERON:0003104 ! composed primarily of mesenchyme property_value: skos:prefLabel "developing mesenchymal structure" xsd:string [Term] id: UBERON:0017651 name: salivary gland primordium def: "A primordium that has the potential to develop into a saliva-secreting gland." [OBOL:automatic] is_a: UBERON:0001048 ! primordium is_a: UBERON:0006598 ! presumptive structure intersection_of: UBERON:0001048 ! primordium intersection_of: RO:0002387 UBERON:0001044 ! has potential to develop into saliva-secreting gland relationship: RO:0002387 UBERON:0001044 ! has potential to develop into saliva-secreting gland [Term] id: UBERON:0017654 name: buccal gland def: "Any of the small racemose mucous glands in the mucous membrane lining the cheeks." [http://www.merriam-webster.com/medical/buccal%20gland] synonym: "cheek gland" RELATED [] xref: BTO:0005767 xref: SCTID:25421004 is_a: UBERON:0000414 ! mucous gland intersection_of: UBERON:0000414 ! mucous gland intersection_of: BFO:0000050 UBERON:0001567 ! part of cheek relationship: BFO:0000050 UBERON:0001567 ! part of cheek [Term] id: UBERON:0017659 name: ventral surface of penis subset: pheno_slim synonym: "urethral surface of penis" EXACT [FMA:19624] xref: FMA:19624 is_a: UBERON:0036215 ! anatomical surface region intersection_of: UBERON:0036215 ! anatomical surface region intersection_of: BSPO:0015102 UBERON:0000989 ! penis relationship: BSPO:0015102 UBERON:0000989 ! penis [Term] id: UBERON:0017672 name: abdominal viscera def: "A viscus that is part of a abdomen." [OBOL:automatic] subset: pheno_slim synonym: "abdominal viscera" EXACT [FMA:32413] synonym: "abdominal viscera set" EXACT [FMA:32413] synonym: "set of abdominal viscera" EXACT [FMA:32413] xref: FMA:32413 xref: FMA:67355 is_a: UBERON:0002075 ! viscus is_a: UBERON:0005172 ! abdomen element intersection_of: UBERON:0002075 ! viscus intersection_of: BFO:0000050 UBERON:0000916 ! part of abdomen property_value: skos:prefLabel "abdominal viscera" xsd:string [Term] id: UBERON:0017750 name: proximal mesopodial endochondral element def: "A mesopodial endochondral element that is in the most proximal part of the mesopodial skeleton, connected to the zeugopodial skeleton." [http://orcid.org/0000-0002-6601-2165] is_a: UBERON:0015063 ! autopod endochondral element intersection_of: UBERON:0010363 ! endochondral element intersection_of: BFO:0000050 UBERON:0006716 ! part of mesopodium region intersection_of: RO:0002170 UBERON:0011584 ! connected to zeugopodial skeleton relationship: BFO:0000050 UBERON:0009878 ! part of mesopodial skeleton relationship: RO:0002170 UBERON:0011584 ! connected to zeugopodial skeleton property_value: IAO:0000116 "awaiting approval by phenoscape curators" xsd:string [Term] id: UBERON:0017751 name: proximal mesopodial cartilage element def: "A proximal mesopodial endochondral element that is composed primarily of cartilage tissue." [OBOL:automatic] is_a: UBERON:0015064 ! autopod cartilage is_a: UBERON:0017750 ! proximal mesopodial endochondral element intersection_of: UBERON:0017750 ! proximal mesopodial endochondral element intersection_of: RO:0002473 UBERON:0002418 ! composed primarily of cartilage tissue [Term] id: UBERON:0018111 name: muscle layer of rectum def: "A muscle layer that is part of the rectum." [http://orcid.org/0000-0002-6601-2165] synonym: "muscular coat of rectum" EXACT [FMA:15035] synonym: "muscularis externa of rectum" EXACT [FMA:15035] synonym: "rectal muscularis propria" EXACT [FMA:15035] synonym: "tunica muscularis (rectum)" EXACT [FMA:15035] synonym: "tunica muscularis recti" EXACT [FMA:TA] xref: FMA:15035 is_a: UBERON:0011198 ! muscle layer of large intestine intersection_of: UBERON:0006660 ! muscular coat intersection_of: BFO:0000050 UBERON:0001052 ! part of rectum relationship: BFO:0000050 UBERON:0001052 ! part of rectum property_value: skos:prefLabel "muscle layer of rectum" xsd:string [Term] id: UBERON:0018112 name: rectum smooth muscle tissue def: "Any portion of smooth muscle tissue that is part of the rectum." [http://orcid.org/0000-0002-6601-2165] synonym: "rectal smooth muscle tissue" EXACT [] synonym: "rectum smooth muscle" EXACT [] synonym: "smooth muscle of rectum" EXACT [] is_a: UBERON:0004220 ! large intestine smooth muscle is_a: UBERON:0004231 ! anal region smooth muscle is_a: UBERON:0016886 ! muscle tissue of terminal part of digestive tract intersection_of: UBERON:0001135 ! smooth muscle tissue intersection_of: BFO:0000050 UBERON:0001052 ! part of rectum relationship: BFO:0000050 UBERON:0001052 ! part of rectum property_value: skos:prefLabel "rectum smooth muscle tissue" xsd:string [Term] id: UBERON:0018113 name: left kidney interstitium def: "A kidney interstitium that is part of a left kidney." [OBOL:automatic] synonym: "left renal stroma" EXACT [FMA:74271] synonym: "stroma of left kidney" EXACT [FMA:74271] xref: FMA:74271 is_a: UBERON:0005215 ! kidney interstitium intersection_of: UBERON:0005215 ! kidney interstitium intersection_of: BFO:0000050 UBERON:0004538 ! part of left kidney relationship: BFO:0000050 UBERON:0004538 ! part of left kidney [Term] id: UBERON:0018114 name: right kidney interstitium def: "A kidney interstitium that is part of a right kidney." [OBOL:automatic] synonym: "right renal stroma" EXACT [FMA:74270] synonym: "stroma of right kidney" EXACT [FMA:74270] xref: FMA:74270 is_a: UBERON:0005215 ! kidney interstitium intersection_of: UBERON:0005215 ! kidney interstitium intersection_of: BFO:0000050 UBERON:0004539 ! part of right kidney relationship: BFO:0000050 UBERON:0004539 ! part of right kidney [Term] id: UBERON:0018115 name: left renal pelvis def: "A renal pelvis that is part of a left ureter." [OBOL:automatic] synonym: "pelvis of left ureter" EXACT [FMA:15579] synonym: "renal pelvis of left kidney" EXACT [FMA:15579] xref: FMA:15579 xref: SCTID:243436005 is_a: UBERON:0001224 ! renal pelvis intersection_of: UBERON:0001224 ! renal pelvis intersection_of: BFO:0000050 UBERON:0001223 ! part of left ureter relationship: BFO:0000050 UBERON:0001223 ! part of left ureter [Term] id: UBERON:0018116 name: right renal pelvis def: "A renal pelvis that is part of a right ureter." [OBOL:automatic] synonym: "pelvis of right kidney" EXACT [FMA:15578] synonym: "pelvis of right ureter" EXACT [FMA:15578] xref: FMA:15578 xref: SCTID:243419002 is_a: UBERON:0001224 ! renal pelvis intersection_of: UBERON:0001224 ! renal pelvis intersection_of: BFO:0000050 UBERON:0001222 ! part of right ureter relationship: BFO:0000050 UBERON:0001222 ! part of right ureter [Term] id: UBERON:0018117 name: left renal cortex interstitium def: "A renal cortex interstitium that is part of a left kidney." [OBOL:automatic] synonym: "cortical interstitial tissue of left kidney" EXACT [] is_a: UBERON:0005270 ! renal cortex interstitium is_a: UBERON:0018113 ! left kidney interstitium intersection_of: UBERON:0005270 ! renal cortex interstitium intersection_of: BFO:0000050 UBERON:0004538 ! part of left kidney [Term] id: UBERON:0018118 name: right renal cortex interstitium def: "A renal cortex interstitium that is part of a right kidney." [OBOL:automatic] synonym: "cortical interstitial tissue of right kidney" EXACT [] is_a: UBERON:0005270 ! renal cortex interstitium is_a: UBERON:0018114 ! right kidney interstitium intersection_of: UBERON:0005270 ! renal cortex interstitium intersection_of: BFO:0000050 UBERON:0004539 ! part of right kidney [Term] id: UBERON:0018119 name: left renal medulla interstitium def: "A renal medulla interstitium that is part of a left kidney." [OBOL:automatic] synonym: "medullary interstitial tissue of left kidney" EXACT [] is_a: UBERON:0005211 ! renal medulla interstitium is_a: UBERON:0018113 ! left kidney interstitium intersection_of: UBERON:0005211 ! renal medulla interstitium intersection_of: BFO:0000050 UBERON:0004538 ! part of left kidney [Term] id: UBERON:0018120 name: right renal medulla interstitium def: "A renal medulla interstitium that is part of a right kidney." [OBOL:automatic] synonym: "medullary interstitial tissue of right kidney" EXACT [] is_a: UBERON:0005211 ! renal medulla interstitium is_a: UBERON:0018114 ! right kidney interstitium intersection_of: UBERON:0005211 ! renal medulla interstitium intersection_of: BFO:0000050 UBERON:0004539 ! part of right kidney [Term] id: UBERON:0018135 name: fibrocollagenous connective tissue xref: FMA:83521 is_a: UBERON:0011824 ! fibrous connective tissue intersection_of: UBERON:0011824 ! fibrous connective tissue intersection_of: RO:0000086 PATO:0002462 ! has quality collagenous relationship: RO:0000086 PATO:0002462 ! has quality collagenous property_value: skos:prefLabel "fibrocollagenous connective tissue" xsd:string [Term] id: UBERON:0018142 name: caudal vertebra endochondral element def: "Any vertebra endochondral element that is part of the caudal region of the vertebral column (tail or coccyx)." [http://orcid.org/0000-0002-6601-2165] synonym: "caudal vertebra element" EXACT [] synonym: "coccygeal vertebra element" NARROW [] synonym: "coccyx vertebra element" NARROW [] synonym: "tail vertebra element" EXACT [] is_a: UBERON:0005174 ! dorsal region element is_a: UBERON:0010913 ! vertebral element intersection_of: UBERON:0010913 ! vertebral element intersection_of: BFO:0000050 UBERON:0006076 ! part of caudal region of vertebral column union_of: UBERON:0001095 ! caudal vertebra union_of: UBERON:0013503 ! caudal vertebra cartilage element union_of: UBERON:0013504 ! caudal vertebra pre-cartilage condensation relationship: BFO:0000050 UBERON:0006076 ! part of caudal region of vertebral column property_value: skos:prefLabel "caudal vertebra endochondral element" xsd:string [Term] id: UBERON:0018143 name: transverse process of cervical vertebra def: "A transverse process that is part of a cervical vertebra." [http://orcid.org/0000-0002-6601-2165] xref: FMA:23894 xref: FMA:9913 xref: SCTID:280730000 is_a: UBERON:0001077 ! transverse process of vertebra intersection_of: UBERON:0001077 ! transverse process of vertebra intersection_of: BFO:0000050 UBERON:0002413 ! part of cervical vertebra relationship: BFO:0000050 UBERON:0002413 ! part of cervical vertebra [Term] id: UBERON:0018144 name: cervical rib def: "A rib that is attached to a cervical vertebra." [http://orcid.org/0000-0002-6601-2165] xref: EMAPA:37825 {source="MA:th"} is_a: UBERON:0002228 ! rib is_a: UBERON:0003458 ! neck bone intersection_of: UBERON:0002228 ! rib intersection_of: RO:0002170 UBERON:0002413 ! connected to cervical vertebra relationship: BFO:0000050 UBERON:0005434 ! part of cervical region relationship: RO:0002170 UBERON:0002413 ! connected to cervical vertebra property_value: IAO:0000116 "Trunk, presacral and sacral ribs do not have a 'part of some region' asserted for them, we should add it to them[PHENOSCAPE:ad]" xsd:string property_value: RO:0002161 NCBITaxon:9606 {source="should be all Theria, see https://github.com/obophenotype/mouse-anatomy-ontology/issues/116"} [Term] id: UBERON:0018145 name: lumbar rib def: "A rib that is attached to a lumbar vertebra." [http://orcid.org/0000-0002-6601-2165] is_a: UBERON:0002228 ! rib intersection_of: UBERON:0002228 ! rib intersection_of: RO:0002170 UBERON:0002414 ! connected to lumbar vertebra relationship: RO:0002170 UBERON:0002414 ! connected to lumbar vertebra property_value: RO:0002161 NCBITaxon:32525 [Term] id: UBERON:0018146 name: transverse process of lumbar vertebra def: "A transverse process that is part of a lumbar vertebra." [http://orcid.org/0000-0002-6601-2165] synonym: "costa lumbalis" EXACT OMO:0003011 [FMA:65469, FMA:TA] synonym: "lumbar transverse process" EXACT [FMA:16080] xref: FMA:16080 xref: FMA:65469 xref: SCTID:280733003 is_a: UBERON:0001077 ! transverse process of vertebra intersection_of: UBERON:0001077 ! transverse process of vertebra intersection_of: BFO:0000050 UBERON:0002414 ! part of lumbar vertebra relationship: BFO:0000050 UBERON:0002414 ! part of lumbar vertebra [Term] id: UBERON:0018150 name: skin of lower lip def: "A zone of skin that is part of a lower lip." [OBOL:automatic] synonym: "lower lip skin" EXACT [FMA:24767] xref: FMA:24767 xref: SCTID:281630002 is_a: UBERON:0001458 ! skin of lip intersection_of: UBERON:0000014 ! zone of skin intersection_of: BFO:0000050 UBERON:0001835 ! part of lower lip relationship: BFO:0000050 UBERON:0001835 ! part of lower lip property_value: skos:prefLabel "skin of lower lip" xsd:string [Term] id: UBERON:0018151 name: skin of upper lip def: "A zone of skin that is part of a upper lip." [OBOL:automatic] synonym: "upper lip skin" EXACT [FMA:24765] xref: FMA:24765 xref: SCTID:281629007 is_a: UBERON:0001458 ! skin of lip intersection_of: UBERON:0000014 ! zone of skin intersection_of: BFO:0000050 UBERON:0001834 ! part of upper lip relationship: BFO:0000050 UBERON:0001834 ! part of upper lip property_value: skos:prefLabel "skin of upper lip" xsd:string [Term] id: UBERON:0018154 name: ligament of middle ear def: "A ligament that is part of a middle ear." [OBOL:automatic] is_a: UBERON:0000211 ! ligament intersection_of: UBERON:0000211 ! ligament intersection_of: BFO:0000050 UBERON:0001756 ! part of middle ear relationship: BFO:0000050 UBERON:0001756 ! part of middle ear [Term] id: UBERON:0018226 name: pulmonary part of lymphatic system def: "An organ system subdivision that is the part of the lymphoid system that includes the pulmonary lymphatic vessels." [http://orcid.org/0000-0002-6601-2165] subset: pheno_slim synonym: "pulmonary lymphatic chain" EXACT [FMA:67999] synonym: "pulmonary lymphatic vasculature" RELATED [] xref: FMA:67999 is_a: BFO:0000002 is_a: UBERON:0011216 ! organ system subdivision intersection_of: UBERON:0011216 ! organ system subdivision intersection_of: BFO:0000050 UBERON:0002048 ! part of lung intersection_of: BFO:0000050 UBERON:0006558 ! part of lymphatic part of lymphoid system relationship: BFO:0000050 UBERON:0002048 ! part of lung relationship: BFO:0000050 UBERON:0006558 ! part of lymphatic part of lymphoid system relationship: BFO:0000051 UBERON:0018227 ! has part pulmonary lymphatic vessel [Term] id: UBERON:0018227 name: pulmonary lymphatic vessel def: "A lymphatic vessel that is part of a lung." [OBOL:automatic] subset: human_reference_atlas synonym: "lymphatic vessel of lung" EXACT [] xref: FMA:234006 xref: SCTID:321862009 is_a: UBERON:0003456 ! respiratory system lymphatic vessel intersection_of: UBERON:0001473 ! lymphatic vessel intersection_of: BFO:0000050 UBERON:0002048 ! part of lung relationship: BFO:0000050 UBERON:0018226 ! part of pulmonary part of lymphatic system relationship: BFO:0000051 UBERON:0003529 ! has part respiratory system lymphatic vessel endothelium property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0018232 name: axillary sweat gland def: "A sweat gland that is part of a axilla." [OBOL:automatic] synonym: "axillary apocrine sweat gland" EXACT [http://orcid.org/0000-0002-6601-2165] synonym: "sweat gland of axilla" EXACT [http://orcid.org/0000-0002-6601-2165] is_a: UBERON:0000382 {source="ISBN:0123813611"} ! apocrine sweat gland intersection_of: UBERON:0001820 ! sweat gland intersection_of: BFO:0000050 UBERON:0009472 ! part of axilla relationship: BFO:0000050 UBERON:0009472 ! part of axilla property_value: RO:0002161 NCBITaxon:10088 {source="ISBN:0123813611"} [Term] id: UBERON:0018234 name: stroma of pancreas def: "A stroma that is part of a pancreas." [OBOL:automatic] subset: human_reference_atlas synonym: "pancreatic stroma" EXACT [FMA:63121] xref: FMA:63121 is_a: UBERON:0003891 ! stroma intersection_of: UBERON:0003891 ! stroma intersection_of: BFO:0000050 UBERON:0001264 ! part of pancreas relationship: BFO:0000050 UBERON:0001264 ! part of pancreas property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0018235 name: capsule of pancreas def: "A capsule that divides the parenchyma of the pancreas into lobes and lobules." [ISBN:0123813611] synonym: "pancreatic capsule" EXACT [] is_a: UBERON:0003893 ! capsule intersection_of: UBERON:0003893 ! capsule intersection_of: BFO:0000050 UBERON:0001264 ! part of pancreas relationship: BFO:0000050 UBERON:0001264 ! part of pancreas [Term] id: UBERON:0018239 name: rhombomere boundary def: "A boundary delimiting a rhombomere." [GO:0021654] synonym: "rhombomere junction" EXACT [] is_a: UBERON:0007651 ! anatomical junction intersection_of: UBERON:0007651 ! anatomical junction intersection_of: RO:0002176 UBERON:0001892 ! connects rhombomere relationship: BFO:0000050 UBERON:0007277 ! part of presumptive hindbrain relationship: RO:0002176 UBERON:0001892 ! connects rhombomere property_value: skos:prefLabel "rhombomere boundary" xsd:string [Term] id: UBERON:0018243 name: thymic artery def: "A vein that supplies blood to the thymus." [http://orcid.org/0000-0002-6601-2165] comment: The arteries supplying the thymus are derived from the internal thoracic artery, and from the superior thyroid artery and inferior thyroids.[WP] subset: human_reference_atlas synonym: "thymic arteries" RELATED OMO:0003004 [Wikipedia:Thymic_branches_of_internal_thoracic_artery] synonym: "thymic branch of internal thoracic artery" EXACT [FMA:10647] xref: FMA:10647 xref: SCTID:76543001 xref: Wikipedia:Thymic_branches_of_internal_thoracic_artery is_a: UBERON:0001637 ! artery intersection_of: UBERON:0001637 ! artery intersection_of: RO:0020101 UBERON:0002370 ! vessel supplies blood to thymus relationship: RO:0002252 UBERON:0002456 {source="FMA"} ! connecting branch of internal thoracic artery relationship: RO:0020101 UBERON:0002370 ! vessel supplies blood to thymus property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0018246 name: thyroid vein def: "A vein that drains a thyroid gland." [OBOL:automatic] xref: EMAPA:18648 xref: SCTID:303420005 is_a: UBERON:0001638 ! vein intersection_of: UBERON:0001638 ! vein intersection_of: RO:0020102 UBERON:0002046 ! vessel drains blood from thyroid gland relationship: RO:0020102 UBERON:0002046 ! vessel drains blood from thyroid gland [Term] id: UBERON:0018247 name: cervical thymic artery def: "An artery that supplies a cervical thymus." [http://orcid.org/0000-0002-6601-2165] is_a: UBERON:0018243 ! thymic artery intersection_of: UBERON:0001637 ! artery intersection_of: RO:0020101 UBERON:0009114 ! vessel supplies blood to cervical thymus relationship: RO:0020101 UBERON:0009114 ! vessel supplies blood to cervical thymus [Term] id: UBERON:0018251 name: meningeal vein def: "One of the veins draining a meninix." [http://orcid.org/0000-0002-6601-2165] xref: FMA:50839 xref: SCTID:84842006 is_a: UBERON:0001638 ! vein intersection_of: UBERON:0001638 ! vein intersection_of: RO:0020102 UBERON:0002360 ! vessel drains blood from meninx relationship: RO:0020102 UBERON:0002360 ! vessel drains blood from meninx property_value: skos:prefLabel "meningeal vein" xsd:string [Term] id: UBERON:0018252 name: internal pudendal vein def: "Accompanying vein of internal pudendal artery." [Wikipedia:Internal_pudendal_veins] subset: human_reference_atlas synonym: "internal pudic vein" RELATED [Wikipedia:Internal_pudendal_veins] synonym: "vena pudenda interna" EXACT OMO:0003011 [Wikipedia:Internal_pudendal_veins] xref: FMA:18917 xref: SCTID:14885008 xref: Wikipedia:Internal_pudendal_veins is_a: UBERON:0009029 ! pudendal vein relationship: RO:0002170 UBERON:0001317 ! connected to internal iliac vein property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/blood-vasculature-female/v1.3/assets/3d-vh-f-blood-vasculature.glb" xsd:anyURI property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/blood-vasculature-male/v1.3/assets/3d-vh-m-blood-vasculature.glb" xsd:anyURI property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0018254 name: skeletal musculature subset: grouping_class subset: human_reference_atlas xref: EHDAA2:0001842 xref: EMAPA:35578 is_a: BFO:0000002 is_a: UBERON:0000061 ! anatomical structure relationship: BFO:0000050 UBERON:0000383 {source="MA"} ! part of musculature of body relationship: RO:0002473 UBERON:0014892 ! composed primarily of skeletal muscle organ, vertebrate property_value: IAO:0000116 "Added for consistency with MA EMAPA and EHDAA2. See https://github.com/obophenotype/mouse-anatomy-ontology/issues/104" xsd:string property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "skeletal musculature" xsd:string [Term] id: UBERON:0018255 name: jejunal artery def: "A branch of the superior mesenteric artery that supplies the jejunum." [http://orcid.org/0000-0002-6601-2165, Wikipedia:Jejunal_veins] subset: human_reference_atlas synonym: "jejunal branch of superior mesenteric artery" RELATED [FMA:14808] xref: FMA:14808 xref: SCTID:265391008 xref: Wikipedia:Jejunal_arteries is_a: UBERON:0001637 ! artery intersection_of: UBERON:0001637 ! artery intersection_of: RO:0002252 UBERON:0001182 ! connecting branch of superior mesenteric artery intersection_of: RO:0020101 UBERON:0002115 ! vessel supplies blood to jejunum relationship: RO:0002252 UBERON:0001182 ! connecting branch of superior mesenteric artery relationship: RO:0020101 UBERON:0002115 ! vessel supplies blood to jejunum property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0018256 name: lacrimal vein def: "A vein that drains a lacrimal gland." [OBOL:automatic] subset: human_reference_atlas xref: FMA:51779 xref: SCTID:149582008 is_a: UBERON:0001638 ! vein intersection_of: UBERON:0001638 ! vein intersection_of: RO:0020102 UBERON:0001817 ! vessel drains blood from lacrimal gland relationship: RO:0002170 UBERON:0011192 ! connected to superior ophthalmic vein relationship: RO:0020102 UBERON:0001817 ! vessel drains blood from lacrimal gland property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0018257 name: submucosa of digestive tract def: "Any portion of submucosa that lines the digestive tract." [http://orcid.org/0000-0002-6601-2165] is_a: UBERON:0000009 ! submucosa intersection_of: UBERON:0000009 ! submucosa intersection_of: BFO:0000050 UBERON:0001555 ! part of digestive tract relationship: BFO:0000050 UBERON:0001555 ! part of digestive tract property_value: skos:prefLabel "submucosa of digestive tract" xsd:string [Term] id: UBERON:0018260 name: layer of muscle tissue def: "Any organ component layer that consists of muscle tissue." [http://orcid.org/0000-0002-6601-2165] xref: FMA:45634 xref: NCIT:C75444 xref: UMLS:C0225358 is_a: BFO:0000002 is_a: UBERON:0004923 ! organ component layer intersection_of: UBERON:0004923 ! organ component layer intersection_of: RO:0002473 UBERON:0002385 ! composed primarily of muscle tissue relationship: RO:0002473 UBERON:0002385 ! composed primarily of muscle tissue property_value: skos:prefLabel "layer of muscle tissue" xsd:string [Term] id: UBERON:0018261 name: muscular coat of digestive tract def: "A muscular coat that is part of a digestive tract." [OBOL:automatic] synonym: "muscular layer of digestive tract" RELATED [] synonym: "muscularis externa of digestive tract" RELATED [] synonym: "tunica externa of digestive tract" RELATED [] synonym: "tunica muscularis of digestive tract" EXACT [] is_a: UBERON:0006660 ! muscular coat intersection_of: UBERON:0006660 ! muscular coat intersection_of: BFO:0000050 UBERON:0001555 ! part of digestive tract relationship: BFO:0000050 UBERON:0001555 ! part of digestive tract relationship: RO:0002216 GO:0030432 ! capable of part of peristalsis property_value: skos:prefLabel "muscular coat of digestive tract" xsd:string [Term] id: UBERON:0018303 name: adrenal tissue def: "Tissue that is part of some adrenal gland." [PHENOSCAPE:Alex] synonym: "adrenal gland tissue" EXACT [ncithesaurus:Adrenal_Gland_Tissue] xref: NCIT:C32051 is_a: UBERON:0000479 ! tissue intersection_of: UBERON:0000479 ! tissue intersection_of: BFO:0000050 UBERON:0002369 ! part of adrenal gland relationship: BFO:0000050 UBERON:0002369 ! part of adrenal gland property_value: IAO:0000116 "TODO - describe typology of adrenal gland tissue used in this ontology" xsd:string [Term] id: UBERON:0018321 name: foramen for glossopharyngeal nerve def: "Foramen that allows the passge of the glossopharyngeal nerve (cranial nerve IX)." [PHENOSCAPE:alex] is_a: UBERON:0013685 ! foramen of skull intersection_of: UBERON:0013685 ! foramen of skull intersection_of: RO:0002570 UBERON:0001649 ! conduit for glossopharyngeal nerve relationship: BFO:0000050 UBERON:0003128 ! part of cranium relationship: RO:0002570 UBERON:0001649 ! conduit for glossopharyngeal nerve property_value: skos:prefLabel "foramen for glossopharyngeal nerve" xsd:string [Term] id: UBERON:0018326 name: ilioischiadic foramen def: "Situated just caudal to the acetabulum, the foramen is bound dorsally by the illium and ventrally by the ischium. The foramen transmitts the ischiadic nerves and vessels (Baumel et al. 1993)." [PHENOSCAPE:alex] is_a: UBERON:0005744 ! bone foramen intersection_of: UBERON:0005744 ! bone foramen intersection_of: RO:0002570 UBERON:0001322 ! conduit for sciatic nerve relationship: BFO:0000050 UBERON:0007832 ! part of pelvic girdle skeleton relationship: RO:0002220 UBERON:0001273 ! adjacent to ilium relationship: RO:0002220 UBERON:0001274 ! adjacent to ischium relationship: RO:0002570 UBERON:0001322 ! conduit for sciatic nerve [Term] id: UBERON:0018413 name: facial nerve canal def: "A Z-shaped canal running through the temporal bone from the internal acoustic meatus to the stylomastoid foramen. It is located within the middle ear region, according to its shape it is divided into three main segments: the labyrinthine, the tympanic, and the mastoidal segment ." [Wikipedia:Facial_canal] synonym: "canalis nervi facialis" EXACT OMO:0003011 [FMA:54952, FMA:TA] synonym: "facial canal" EXACT [FMA:54952] synonym: "fallopian canal" RELATED [FMA:54952] xref: FMA:54952 xref: Wikipedia:Facial_canal is_a: UBERON:0013685 ! foramen of skull intersection_of: UBERON:0013685 ! foramen of skull intersection_of: RO:0002570 UBERON:0001647 ! conduit for facial nerve relationship: BFO:0000050 UBERON:0001678 ! part of temporal bone relationship: RO:0002570 UBERON:0001647 ! conduit for facial nerve property_value: skos:prefLabel "facial nerve canal" xsd:string [Term] id: UBERON:0018415 name: ethmoid foramen def: "An bone foramen in the ethmoid bone." [http://orcid.org/0000-0002-6601-2165] comment: Taxon nodes: In humans, refers to anterior or posterior ethmoid foramina synonym: "ethmoid foramina" RELATED OMO:0003004 [] synonym: "ethmoidal foramen" EXACT [] synonym: "ethmoidal foramina" RELATED OMO:0003004 [] synonym: "foramina ethmoidalia" EXACT OMO:0003011 [] xref: Wikipedia:Ethmoidal_foramina is_a: UBERON:0013685 ! foramen of skull intersection_of: UBERON:0004111 ! anatomical conduit intersection_of: BFO:0000050 UBERON:0001679 ! part of ethmoid bone relationship: BFO:0000050 UBERON:0001679 ! part of ethmoid bone property_value: skos:prefLabel "ethmoid foramen" xsd:string [Term] id: UBERON:0018543 name: lumen of intestine def: "The anatomical space within the intestine." [http://orcid.org/0000-0002-6601-2165] synonym: "gut lumen" RELATED [ZFA:0005807] synonym: "intestinal lumen" EXACT [FMA:14586] synonym: "intestine lumen" EXACT [ZFA:0005807] xref: FMA:14586 xref: TADS:0000495 xref: WBbt:0005791 xref: ZFA:0005807 is_a: UBERON:0000464 ! anatomical space intersection_of: UBERON:0000464 ! anatomical space intersection_of: RO:0002572 UBERON:0000160 ! luminal space of intestine relationship: RO:0002572 UBERON:0000160 ! luminal space of intestine property_value: IAO:0000116 "see notes in inclusivity in class 'intestine'" xsd:string property_value: skos:prefLabel "lumen of intestine" xsd:string [Term] id: UBERON:0018544 name: trigeminal nerve muscle def: "Muscle innervated by the trigeminal nerve (Cranial Nerve V)." [MFMO:0000072] synonym: "muscle innervated by the trigeminal nerve" EXACT [] synonym: "muscles innervated by the trigeminal nerve" EXACT OMO:0003004 [MFMO:0000072] xref: MFMO:0000072 is_a: UBERON:0001630 ! muscle organ intersection_of: UBERON:0001630 ! muscle organ intersection_of: RO:0002005 UBERON:0001645 ! innervated by trigeminal nerve relationship: RO:0002005 UBERON:0001645 ! innervated by trigeminal nerve relationship: RO:0002202 UBERON:0004362 ! develops from pharyngeal arch 1 property_value: skos:prefLabel "trigeminal nerve muscle" xsd:string [Term] id: UBERON:0018649 name: cardiac muscle tissue of ventricle synonym: "ventricular cardiac muscle tissue" EXACT [http://orcid.org/0000-0002-6601-2165] synonym: "ventricular heart muscle" EXACT [http://orcid.org/0000-0002-6601-2165] synonym: "ventricular muscle" RELATED [http://orcid.org/0000-0002-6601-2165] xref: FMA:83450 is_a: UBERON:0004493 ! cardiac muscle tissue of myocardium intersection_of: UBERON:0001133 ! cardiac muscle tissue intersection_of: BFO:0000050 UBERON:0002082 ! part of cardiac ventricle relationship: BFO:0000050 UBERON:0001083 ! part of myocardium of ventricle property_value: skos:prefLabel "cardiac muscle tissue of ventricle" xsd:string [Term] id: UBERON:0018664 name: neck of bone element def: "The neck region of a bone organ." [http://orcid.org/0000-0002-6601-2165] synonym: "bone neck" EXACT [] synonym: "neck of bone" EXACT [] is_a: UBERON:0001560 ! neck of organ is_a: UBERON:0005913 ! zone of bone organ intersection_of: UBERON:0001560 ! neck of organ intersection_of: BFO:0000050 UBERON:0001474 ! part of bone element [Term] id: UBERON:0018667 name: neck of scapula synonym: "anatomical neck of scapula" EXACT [FMA:23254] synonym: "collum scapulae" EXACT [] synonym: "scapular neck" EXACT [FMA:23254] xref: FMA:23254 xref: SCTID:181915009 is_a: UBERON:0018664 ! neck of bone element intersection_of: UBERON:0001560 ! neck of organ intersection_of: BFO:0000050 UBERON:0006849 ! part of scapula relationship: BFO:0000050 UBERON:0006849 ! part of scapula [Term] id: UBERON:0018673 name: neck of fibula subset: human_reference_atlas synonym: "fibula neck" EXACT [FMA:35508] synonym: "fibular neck" EXACT [] xref: EMAPA:37891 {source="MA:th"} xref: FMA:35508 is_a: UBERON:0005055 ! zone of long bone is_a: UBERON:0018664 ! neck of bone element intersection_of: UBERON:0001560 ! neck of organ intersection_of: BFO:0000050 UBERON:0001446 ! part of fibula relationship: BFO:0000050 UBERON:0001446 ! part of fibula property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0018674 name: heart vasculature def: "An interconnected tubular multi-tissue structure that contains fluid that is actively transported around the heart." [ZFA:0005811, ZFA:CVS] synonym: "cardiac vasculature" EXACT [FMA:73747] xref: FMA:73747 xref: ZFA:0005811 is_a: UBERON:0002201 ! vasculature of trunk is_a: UBERON:0006876 ! vasculature of organ intersection_of: UBERON:0002049 ! vasculature intersection_of: BFO:0000050 UBERON:0000948 ! part of heart relationship: BFO:0000050 UBERON:0000948 ! part of heart property_value: skos:prefLabel "heart vasculature" xsd:string [Term] id: UBERON:0018679 name: thoracic splanchnic nerve def: "Thoracic splanchnic nerves are splanchnic nerves that arise from the sympathetic trunk in the thorax and travel inferiorly to provide sympathetic innervation to the abdomen. The nerves contain preganglionic sympathetic and general visceral afferent fibers." [Wikipedia:Thoracic_splanchnic_nerves] subset: human_reference_atlas xref: FMA:6280 xref: Wikipedia:Thoracic_splanchnic_nerves is_a: UBERON:0003715 ! splanchnic nerve is_a: UBERON:0003824 ! nerve of thoracic segment intersection_of: UBERON:0003715 ! splanchnic nerve intersection_of: RO:0002176 UBERON:0004863 ! connects thoracic sympathetic nerve trunk relationship: RO:0002176 UBERON:0004863 ! connects thoracic sympathetic nerve trunk relationship: RO:0002380 UBERON:0004863 {source="FMA"} ! branching part of thoracic sympathetic nerve trunk property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0018685 name: nursing stage def: "A mammalian developmental stage that covers the period from birth until weaning." [Bgee:AN] synonym: "suckling stage" EXACT [] xref: ChirDv:0000016 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: GgorDv:0000004 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: HsapDv:0000260 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: MdomDv:0000032 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: MmulDv:0000004 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: MmusDv:0000138 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: OariDv:0000004 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: PpanDv:0000004 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: PtroDv:0000004 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: RnorDv:0000056 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} xref: SscrDv:0000004 {sssom:mapping_justification="https://w3id.org/semapv/vocab/UnspecifiedMatching"} is_a: BFO:0000003 is_a: UBERON:0000105 ! life cycle stage relationship: BFO:0000050 UBERON:0000092 ! part of post-embryonic stage relationship: BFO:0000051 UBERON:0007221 ! has part neonate stage relationship: RO:0002162 NCBITaxon:40674 ! in taxon Mammalia [Term] id: UBERON:0018691 name: ventral side of post-anal tail is_a: UBERON:0034929 ! external soft tissue zone intersection_of: UBERON:0034929 ! external soft tissue zone intersection_of: BSPO:0015102 UBERON:0007812 ! post-anal tail relationship: BFO:0000050 UBERON:0013235 ! part of ventrum relationship: BSPO:0015102 UBERON:0007812 ! post-anal tail property_value: skos:prefLabel "ventral side of post-anal tail" xsd:string [Term] id: UBERON:0018692 name: dorsal side of post-anal tail is_a: UBERON:0034929 ! external soft tissue zone intersection_of: UBERON:0034929 ! external soft tissue zone intersection_of: BSPO:0015101 UBERON:0007812 ! post-anal tail relationship: BFO:0000050 UBERON:0001137 ! part of dorsum relationship: BSPO:0015101 UBERON:0007812 ! post-anal tail property_value: skos:prefLabel "dorsal side of post-anal tail" xsd:string [Term] id: UBERON:0018707 name: bladder organ def: "A membranous sac in animals that serves as the receptacle of a liquid or contains gas." [BTO:0000123] synonym: "bladder" NARROW [BTO:0000123] xref: BTO:0000123 is_a: UBERON:0000489 ! cavitated compound organ is_a: UBERON:0009856 ! sac relationship: RO:0000086 PATO:0002468 ! has quality distensible relationship: RO:0001015 UBERON:0000463 ! location of organism substance property_value: skos:prefLabel "bladder organ" xsd:string [Term] id: UBERON:0019042 name: reproductive system mucosa synonym: "genital mucosa" EXACT [BTO:0002439] xref: BTO:0002439 is_a: UBERON:0000344 ! mucosa is_a: UBERON:0005156 ! reproductive structure intersection_of: UBERON:0000344 ! mucosa intersection_of: BFO:0000050 UBERON:0000990 ! part of reproductive system property_value: skos:prefLabel "reproductive system mucosa" xsd:string [Term] id: UBERON:0019143 name: intramuscular adipose tissue def: "Adipose tissue which is located throughout skeletal muscle and is responsible for the marbling seen in certain cuts of beef. In humans, excess accumulation of intramuscular fat is associated with insulin resistance and type 2 diabetes." [BTO:0004043] synonym: "intramuscular fat" RELATED [BTO:0004043] xref: BTO:0004043 is_a: UBERON:0001013 ! adipose tissue intersection_of: UBERON:0001013 ! adipose tissue intersection_of: BFO:0000050 UBERON:0014892 ! part of skeletal muscle organ, vertebrate relationship: BFO:0000050 UBERON:0014892 ! part of skeletal muscle organ, vertebrate property_value: skos:prefLabel "intramuscular adipose tissue" xsd:string [Term] id: UBERON:0019189 name: carotid artery endothelium synonym: "carotid endothelium" RELATED [BTO:0004626] synonym: "carotid epithelium" RELATED [] xref: BTO:0004626 is_a: UBERON:0001917 ! endothelium of artery intersection_of: UBERON:0001986 ! endothelium intersection_of: BFO:0000050 UBERON:0005396 ! part of carotid artery segment relationship: BFO:0000050 UBERON:0005396 ! part of carotid artery segment property_value: skos:prefLabel "carotid artery endothelium" xsd:string [Term] id: UBERON:0019190 name: mucous gland of lung synonym: "bronchial gland" EXACT [FMA:13119] synonym: "bronchial mucous gland" EXACT [FMA:13119] synonym: "peribronchial gland" EXACT [BTO:0004638] xref: BTO:0004638 xref: FMA:13119 xref: SCTID:88410004 is_a: UBERON:0000414 ! mucous gland is_a: UBERON:0005181 ! thoracic segment organ is_a: UBERON:0036225 ! respiratory system gland intersection_of: UBERON:0000414 ! mucous gland intersection_of: BFO:0000050 UBERON:0002048 ! part of lung relationship: BFO:0000050 UBERON:0002048 ! part of lung property_value: skos:prefLabel "mucous gland of lung" xsd:string [Term] id: UBERON:0019196 name: iliac artery endothelium xref: BTO:0004661 is_a: UBERON:0001917 ! endothelium of artery intersection_of: UBERON:0001986 ! endothelium intersection_of: BFO:0000050 UBERON:0005609 ! part of iliac artery relationship: BFO:0000050 UBERON:0005609 ! part of iliac artery [Term] id: UBERON:0019204 name: skin epithelium def: "Any region of epithelium that is part of a skin region." [http://orcid.org/0000-0002-6601-2165] xref: BTO:0004382 is_a: UBERON:0000483 ! epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: BFO:0000050 UBERON:0000014 ! part of zone of skin relationship: BFO:0000050 UBERON:0000014 ! part of zone of skin property_value: skos:prefLabel "skin epithelium" xsd:string [Term] id: UBERON:0019206 name: tongue papilla epithelium xref: EMAPA:35869 xref: MA:0003178 is_a: UBERON:0002424 ! oral epithelium is_a: UBERON:0003357 ! epithelium of tongue intersection_of: UBERON:0000483 ! epithelium intersection_of: BFO:0000050 UBERON:0001726 ! part of papilla of tongue relationship: BFO:0000050 UBERON:0001726 ! part of papilla of tongue property_value: skos:prefLabel "tongue papilla epithelium" xsd:string [Term] id: UBERON:0019207 name: chorioretinal region def: "The part of the eye that consists of both the retina and the optic choroid." [http://orcid.org/0000-0002-6601-2165, UBERON:drseb] subset: pheno_slim synonym: "chorioretina" EXACT [] synonym: "choroid and retina" EXACT [] synonym: "retinachoroid" EXACT [] synonym: "retinachoroidal region" EXACT [] xref: SCTID:110701000 is_a: BFO:0000002 is_a: UBERON:0000481 ! multi-tissue structure relationship: BFO:0000050 UBERON:0010230 ! part of eyeball of camera-type eye relationship: BFO:0000051 UBERON:0000966 ! has part retina relationship: BFO:0000051 UBERON:0001776 ! has part optic choroid property_value: skos:prefLabel "chorioretinal region" xsd:string [Term] id: UBERON:0019258 name: white matter of hindbrain def: "A white matter that is part of the hindbrain." [OBOL:automatic] subset: human_reference_atlas xref: DHBA:10668 xref: FMA:268636 is_a: UBERON:0003544 ! brain white matter intersection_of: UBERON:0002316 ! white matter intersection_of: BFO:0000050 UBERON:0002028 ! part of hindbrain relationship: BFO:0000050 UBERON:0002028 ! part of hindbrain property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "white matter of hindbrain" xsd:string [Term] id: UBERON:0019261 name: white matter of forebrain def: "A white matter that is part of the forebrain." [OBOL:automatic] subset: human_reference_atlas xref: DHBA:10557 xref: FMA:268634 is_a: UBERON:0003544 ! brain white matter intersection_of: UBERON:0002316 ! white matter intersection_of: BFO:0000050 UBERON:0001890 ! part of forebrain relationship: BFO:0000050 UBERON:0001890 ! part of forebrain property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "white matter of forebrain" xsd:string [Term] id: UBERON:0019262 name: white matter of myelencephalon def: "A white matter that is part of the myelencephalon." [OBOL:automatic] synonym: "myelencephalic white matter" EXACT [HBA:MYWM] xref: HBA:9298 is_a: UBERON:0019258 ! white matter of hindbrain intersection_of: UBERON:0002316 ! white matter intersection_of: BFO:0000050 UBERON:0005290 ! part of myelencephalon relationship: BFO:0000050 UBERON:0005290 ! part of myelencephalon property_value: skos:prefLabel "white matter of myelencephalon" xsd:string [Term] id: UBERON:0019263 name: gray matter of hindbrain subset: human_reference_atlas synonym: "gray matter of the hindbrain" EXACT [DHBA:HGM] xref: DHBA:10654 xref: FMA:268630 is_a: UBERON:0003528 ! brain gray matter intersection_of: UBERON:0002020 ! gray matter intersection_of: BFO:0000050 UBERON:0002028 ! part of hindbrain relationship: BFO:0000050 UBERON:0002028 ! part of hindbrain property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "gray matter of hindbrain" xsd:string [Term] id: UBERON:0019264 name: gray matter of forebrain subset: human_reference_atlas xref: DHBA:10157 xref: FMA:268608 is_a: UBERON:0003528 ! brain gray matter intersection_of: UBERON:0002020 ! gray matter intersection_of: BFO:0000050 UBERON:0001890 ! part of forebrain relationship: BFO:0000050 UBERON:0001890 ! part of forebrain property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "gray matter of forebrain" xsd:string [Term] id: UBERON:0019267 name: gray matter of midbrain subset: human_reference_atlas xref: DHBA:10649 xref: FMA:83913 is_a: UBERON:0003528 ! brain gray matter intersection_of: UBERON:0002020 ! gray matter intersection_of: BFO:0000050 UBERON:0001891 ! part of midbrain relationship: BFO:0000050 UBERON:0001891 ! part of midbrain property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "gray matter of midbrain" xsd:string [Term] id: UBERON:0019269 name: gray matter of diencephalon xref: FMA:83912 is_a: UBERON:0019264 ! gray matter of forebrain intersection_of: UBERON:0002020 ! gray matter intersection_of: BFO:0000050 UBERON:0001894 ! part of diencephalon relationship: BFO:0000050 UBERON:0001894 ! part of diencephalon property_value: skos:prefLabel "gray matter of diencephalon" xsd:string [Term] id: UBERON:0019291 name: white matter of metencephalon xref: FMA:83939 xref: HBA:9287 is_a: UBERON:0019258 ! white matter of hindbrain intersection_of: UBERON:0002316 ! white matter intersection_of: BFO:0000050 UBERON:0001895 ! part of metencephalon relationship: BFO:0000050 UBERON:0001895 ! part of metencephalon property_value: skos:prefLabel "white matter of metencephalon" xsd:string [Term] id: UBERON:0019292 name: white matter of pons xref: FMA:83940 is_a: UBERON:0014891 ! brainstem white matter is_a: UBERON:0019291 ! white matter of metencephalon intersection_of: UBERON:0002316 ! white matter intersection_of: BFO:0000050 UBERON:0000988 ! part of pons relationship: BFO:0000050 UBERON:0000988 ! part of pons property_value: skos:prefLabel "white matter of pons" xsd:string [Term] id: UBERON:0019293 name: white matter of pontine tegmentum synonym: "pontine white matter tracts" EXACT [HBA:PoWM] synonym: "predominantly white regional part of pontine tegmentum" EXACT [BIRNLEX:1069] synonym: "substantia alba tegmenti pontis" EXACT [FMA:TA] synonym: "white matter of pontile tegmentum" EXACT [FMA:83942] synonym: "white substance of pontile tegmentum" EXACT [FMA:83942] xref: BIRNLEX:1069 xref: FMA:83942 xref: HBA:265505486 is_a: UBERON:0019292 ! white matter of pons intersection_of: UBERON:0002316 ! white matter intersection_of: BFO:0000050 UBERON:0003023 ! part of pontine tegmentum relationship: BFO:0000050 UBERON:0003023 ! part of pontine tegmentum property_value: skos:prefLabel "white matter of pontine tegmentum" xsd:string [Term] id: UBERON:0019294 name: commissure of telencephalon synonym: "telencephalic commissures" EXACT [HBA:TELCom] xref: HBA:9220 is_a: UBERON:0005970 ! brain commissure intersection_of: UBERON:0001020 ! nervous system commissure intersection_of: BFO:0000050 UBERON:0001893 ! part of telencephalon relationship: BFO:0000050 UBERON:0001893 ! part of telencephalon property_value: skos:prefLabel "commissure of telencephalon" xsd:string [Term] id: UBERON:0019304 name: sensory organ epithelium xref: EMAPA:35952 xref: MA:0003174 is_a: UBERON:0000483 ! epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: BFO:0000050 UBERON:0000020 ! part of sense organ relationship: BFO:0000050 UBERON:0000020 ! part of sense organ property_value: skos:prefLabel "sensory organ epithelium" xsd:string [Term] id: UBERON:0019306 name: nose epithelium xref: EMAPA:35958 xref: MA:0003171 is_a: UBERON:0019304 ! sensory organ epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: BFO:0000050 UBERON:0000004 ! part of nose relationship: BFO:0000050 UBERON:0000004 ! part of nose property_value: skos:prefLabel "nose epithelium" xsd:string [Term] id: UBERON:0019307 name: epithelium of external nose def: "Epithelial layer that is part of the external part of the nose." [http://orcid.org/0000-0002-6601-2165] synonym: "epithelium of skin of external nose" EXACT [FMA:63143] xref: FMA:63143 is_a: UBERON:0012329 {source="FMA"} ! keratinized stratified squamous epithelium is_a: UBERON:0019306 ! nose epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: BFO:0000050 UBERON:0007827 ! part of external nose relationship: BFO:0000050 UBERON:0007827 ! part of external nose [Term] id: UBERON:0019310 name: glossopharyngeal nerve root synonym: "glossopharyngeal nerve root" EXACT [BIRNLEX:1533] xref: BIRNLEX:1533 xref: DHBA:12887 xref: DMBA:17747 xref: HBA:9334 is_a: UBERON:0006843 ! root of cranial nerve intersection_of: UBERON:0002211 ! nerve root intersection_of: extends_fibers_into UBERON:0001649 ! glossopharyngeal nerve relationship: BFO:0000050 UBERON:0001896 ! part of medulla oblongata relationship: extends_fibers_into UBERON:0001649 ! glossopharyngeal nerve property_value: skos:prefLabel "glossopharyngeal nerve root" xsd:string [Term] id: UBERON:0019311 name: root of olfactory nerve def: "The initial segment of an olfactory nerve, leaving the central nervous system." [http://orcid.org/0000-0002-6601-2165] synonym: "olfactory nerve root" EXACT [BIRNLEX:1632] xref: BIRNLEX:1632 is_a: UBERON:0002211 ! nerve root intersection_of: UBERON:0002211 ! nerve root intersection_of: extends_fibers_into UBERON:0001579 ! olfactory nerve relationship: extends_fibers_into UBERON:0001579 ! olfactory nerve property_value: skos:prefLabel "root of olfactory nerve" xsd:string [Term] id: UBERON:0019319 name: exocrine gland of integumental system def: "An exocrine gland that is part of a integumental system." [GOC:dos, http://orcid.org/0000-0002-6601-2165] synonym: "integumental exocrine gland" EXACT [http://orcid.org/0000-0002-6601-2165] synonym: "integumental system exocrine gland" EXACT [http://orcid.org/0000-0002-6601-2165] is_a: UBERON:0002365 ! exocrine gland is_a: UBERON:0003297 ! gland of integumental system intersection_of: UBERON:0002365 ! exocrine gland intersection_of: BFO:0000050 UBERON:0002416 ! part of integumental system property_value: skos:prefLabel "exocrine gland of integumental system" xsd:string [Term] id: UBERON:0020358 name: accessory XI nerve nucleus def: "The spinal accessory nucleus lies within the cervical spinal cord (C1-C5) in the ventral horn. The nucleus ambiguus is classically said to provide the 'cranial component' of the accessory nerve. However, the very existence of this cranial component has been recently questioned and seen as contributing exclusively to the vagus nerve. The terminology continues to be used in describing both human anatomy, and that of other animals." [Wikipedia:Spinal_accessory_nucleus] comment: See also: Wikipedia:Spinal_accessory_nucleus synonym: "accessory neural nucleus" EXACT [FMA:83965] synonym: "accessory nucleus of anterior column of spinal cord" RELATED [NeuroNames:2003] synonym: "nucleus accessorius columnae anterioris medullae spinalis" RELATED OMO:0003011 [NeuroNames:2003] synonym: "nucleus nervi accessorii" RELATED OMO:0003011 [NeuroNames:2003] synonym: "nucleus of accessory nerve" RELATED [NeuroNames:2003] synonym: "nucleus of the accessory nerve" RELATED [NeuroNames:2003] synonym: "nucleus of the spinal accessory nerve" RELATED [NeuroNames:2003] synonym: "spinal accessory nucleus" RELATED [http://orcid.org/0000-0002-6601-2165] xref: EMAPA:37067 {source="MA:th"} xref: FMA:83965 xref: MA:0001033 xref: neuronames:2003 xref: Wikipedia:Spinal_accessory_nucleus is_a: UBERON:0000126 {source="FMA"} ! cranial nerve nucleus is_a: UBERON:0007635 ! nucleus of medulla oblongata property_value: skos:prefLabel "accessory XI nerve nucleus" xsd:string [Term] id: UBERON:0020550 name: auricular blood vessel def: "A blood vessel that supplies or drains an ear." [http://orcid.org/0000-0002-6601-2165] xref: EMAPA:37386 {source="MA:th"} xref: MA:0001226 is_a: UBERON:0001981 ! blood vessel intersection_of: UBERON:0001981 ! blood vessel intersection_of: RO:0002170 UBERON:0001690 ! connected to ear relationship: RO:0002170 UBERON:0001690 ! connected to ear property_value: skos:prefLabel "auricular blood vessel" xsd:string [Term] id: UBERON:0022230 name: retrohippocampal region synonym: "retrohippocampal cortex" EXACT [MA:0000920] xref: EMAPA:35745 xref: MA:0000920 xref: MBA:822 xref: neuronames:2729 is_a: UBERON:0002616 ! regional part of brain relationship: BFO:0000050 UBERON:0002421 {source="ABA"} ! part of hippocampal formation property_value: skos:prefLabel "retrohippocampal region" xsd:string [Term] id: UBERON:0022235 name: peduncle of diencephalon synonym: "diencephalon peduncle" EXACT [FMA:62444] xref: FMA:62444 is_a: UBERON:0003931 ! diencephalic white matter is_a: UBERON:0007417 ! peduncle of neuraxis intersection_of: UBERON:0007417 ! peduncle of neuraxis intersection_of: BFO:0000050 UBERON:0001894 ! part of diencephalon property_value: skos:prefLabel "peduncle of diencephalon" xsd:string [Term] id: UBERON:0022236 name: peduncle of thalamus synonym: "thalamic peduncle" EXACT [] xref: MBA:365 xref: neuronames:1982 is_a: UBERON:0022235 ! peduncle of diencephalon intersection_of: UBERON:0007417 ! peduncle of neuraxis intersection_of: BFO:0000050 UBERON:0001897 ! part of dorsal plus ventral thalamus relationship: BFO:0000050 UBERON:0001897 ! part of dorsal plus ventral thalamus property_value: skos:prefLabel "peduncle of thalamus" xsd:string [Term] id: UBERON:0022247 name: forebrain ipsilateral fiber tracts synonym: "FIFT" RELATED OMO:0003000 [DHBA:FIFT] xref: DHBA:10568 is_a: UBERON:0005838 ! fasciculus of brain relationship: BFO:0000050 UBERON:0019261 {source="DHBA"} ! part of white matter of forebrain property_value: skos:prefLabel "forebrain ipsilateral fiber tracts" xsd:string [Term] id: UBERON:0022248 name: cerebral nerve fasciculus synonym: "cerebral fascicle" EXACT [FMA:260712] synonym: "cerebral fasciculus" EXACT [FMA:260712] synonym: "nerve fascicle of telencephalon" EXACT [] synonym: "telencephalic fascicle" EXACT [] synonym: "telencephalic nerve fascicle" EXACT [] xref: FMA:260712 is_a: UBERON:0005838 ! fasciculus of brain intersection_of: UBERON:0001019 ! nerve fasciculus intersection_of: BFO:0000050 UBERON:0001893 ! part of telencephalon relationship: BFO:0000050 UBERON:0001893 ! part of telencephalon property_value: skos:prefLabel "cerebral nerve fasciculus" xsd:string [Term] id: UBERON:0022254 name: ventral thalamic fasciculus def: "The thalamic fasciculus is a component of the subthalamus. It is sometimes considered synonymous with 'field H1 of Forel'. Nerve fibres forming a composite bundle containing cerebellothalamic (crossed) and pallidothalamic (uncrossed) fibres that is insinuated between the thalamus and zona incerta. The thalamic fasciculus consists of the joint fibers of the ansa lenticularis and the lenticular fasciculus, coming from different portions of the medial globus pallidus, before they jointly enter the ventral lateral nucleus of the thalamus." [Wikipedia:Thalamic_fasciculus] synonym: "area subthalamica tegmentalis, pars dorsomedialis" EXACT OMO:0003011 [FMA:62065, FMA:TA] synonym: "area tegmentalis H1" EXACT OMO:0003011 [FMA:62065, FMA:TA] synonym: "area tegmentalis, pars dorsalis" EXACT OMO:0003011 [FMA:62065, FMA:TA] synonym: "area tegmentalis, pars dorsalis (Forel)" EXACT OMO:0003011 [FMA:62065, FMA:TA] synonym: "campus foreli (pars dorsalis)" EXACT OMO:0003011 [FMA:62065, FMA:TA] synonym: "fasciculus thalamicus" EXACT [FMA:TA] synonym: "fasciculus thalamicus [h1]" EXACT [FMA:TA] synonym: "fasciculus thalamicus hypothalami" EXACT OMO:0003011 [FMA:62065, FMA:TA] synonym: "field H1" EXACT [FMA:62065] synonym: "forel's field h1" EXACT [FMA:62065] synonym: "forelli campus I" EXACT OMO:0003011 [FMA:62065, FMA:TA] synonym: "h1 bundle of Forel" EXACT OMO:0003011 [FMA:62065, FMA:TA] synonym: "h1 field of Forel" EXACT OMO:0003011 [FMA:62065, FMA:TA] synonym: "tegmental area h1" EXACT [FMA:62065] synonym: "thalamic fasciculus" EXACT [FMA:62065] synonym: "thalamic fasciculus [h1]" EXACT [FMA:62065] xref: DHBA:10593 xref: FMA:62065 xref: HBA:265505374 xref: neuronames:439 xref: SCTID:369185006 xref: Wikipedia:Thalamic_fasciculus is_a: UBERON:0005838 ! fasciculus of brain intersection_of: UBERON:0005838 ! fasciculus of brain intersection_of: BFO:0000050 UBERON:0001900 ! part of ventral thalamus relationship: BFO:0000050 UBERON:0001900 ! part of ventral thalamus relationship: BFO:0000050 UBERON:0022247 {source="DHBA"} ! part of forebrain ipsilateral fiber tracts property_value: skos:prefLabel "ventral thalamic fasciculus" xsd:string [Term] id: UBERON:0022279 name: strand of hair on external ear synonym: "hair of external ear" EXACT [FMA:53671] synonym: "hair of tragus" EXACT [FMA:53671] synonym: "tragus hair" EXACT [FMA:53671] xref: FMA:53671 is_a: UBERON:0016446 ! hair of head intersection_of: UBERON:0001037 ! strand of hair intersection_of: BFO:0000050 UBERON:0001691 ! part of external ear relationship: BFO:0000050 UBERON:0001691 ! part of external ear [Term] id: UBERON:0022280 name: epithelium of crypt of Lieberkuhn of small intestine synonym: "epithelium of small intestinal crypt of Lieberkuhn" EXACT [FMA:63243] synonym: "wall of small intestinal crypt of Lieberkuhn" RELATED [FMA:63243] xref: FMA:63243 is_a: UBERON:0001902 ! epithelium of small intestine is_a: UBERON:0011184 ! epithelium of crypt of Lieberkuhn intersection_of: UBERON:0000483 ! epithelium intersection_of: BFO:0000050 UBERON:0001241 ! part of crypt of Lieberkuhn of small intestine relationship: BFO:0000050 UBERON:0001241 ! part of crypt of Lieberkuhn of small intestine [Term] id: UBERON:0022281 name: epithelium of crypt of Lieberkuhn of large intestine xref: FMA:63628 is_a: UBERON:0001278 ! epithelium of large intestine is_a: UBERON:0011184 ! epithelium of crypt of Lieberkuhn intersection_of: UBERON:0000483 ! epithelium intersection_of: BFO:0000050 UBERON:0001984 ! part of crypt of Lieberkuhn of large intestine relationship: BFO:0000050 UBERON:0001984 ! part of crypt of Lieberkuhn of large intestine [Term] id: UBERON:0022284 name: lacrimal gland bud def: "The single bud-like invagination of the conjunctival fornix epithelium at the temporal aspect of the eye that signals lacrimal gland formation (Int Rev Cytol. 1996;168:1-80. Cell biology of the harderian gland)." [MGI:anna] xref: EMAPA:35464 is_a: UBERON:0005153 ! epithelial bud is_a: UBERON:0015808 ! eye epithelium relationship: BFO:0000050 UBERON:0001750 ! part of lacrimal apparatus [Term] id: UBERON:0022288 name: surface of eyeball synonym: "surface of region of wall of eyeball" RELATED [FMA:58315] xref: FMA:58315 is_a: UBERON:0036215 ! anatomical surface region intersection_of: UBERON:0036215 ! anatomical surface region intersection_of: RO:0002007 UBERON:0010230 ! bounding layer of eyeball of camera-type eye relationship: RO:0002007 UBERON:0010230 ! bounding layer of eyeball of camera-type eye property_value: skos:prefLabel "surface of eyeball" xsd:string [Term] id: UBERON:0022292 name: splenic arteriole xref: NCIT:C33596 xref: SCTID:282511007 is_a: UBERON:0001980 ! arteriole is_a: UBERON:0003497 ! abdomen blood vessel intersection_of: UBERON:0001980 ! arteriole intersection_of: BFO:0000050 UBERON:0002106 ! part of spleen relationship: BFO:0000050 UBERON:0002106 ! part of spleen property_value: skos:prefLabel "splenic arteriole" xsd:string [Term] id: UBERON:0022293 name: reproductive gland secretion def: "A portion of organism substance that is secreted by a reproductive gland." [UBERON:cjm] synonym: "genital fluid" RELATED [] synonym: "genital secretion" RELATED [] synonym: "reproductive system fluid" RELATED [] synonym: "reproductive system fluid/secretion" RELATED [] synonym: "reproductive system secretion" RELATED [] is_a: UBERON:0000463 ! organism substance intersection_of: UBERON:0000463 ! organism substance intersection_of: RO:0003001 UBERON:0003937 ! produced by reproductive gland relationship: RO:0003001 UBERON:0003937 ! produced by reproductive gland property_value: skos:prefLabel "reproductive gland secretion" xsd:string [Term] id: UBERON:0022302 name: short ciliary nerve def: "A branch of the ciliary ganglion that innervates the ciliary muscles, the iris, and the tunics of the eyeball." [http://medical-dictionary.thefreedictionary.com/long+ciliary+nerve, UBERON:cjm] subset: human_reference_atlas synonym: "lower branch of ciliary ganglion" EXACT [FMA:7041] synonym: "nervi ciliares breves" RELATED OMO:0003011 [Wikipedia:Short_ciliary_nerves] synonym: "nervi ciliares brevis" RELATED OMO:0003011 [] synonym: "short ciliary nerve" RELATED [Wikipedia:Short_ciliary_nerves] xref: FMA:7041 xref: SCTID:417598000 xref: Wikipedia:Short_ciliary_nerves is_a: UBERON:0003438 ! iris nerve is_a: UBERON:0004293 ! parasympathetic nerve is_a: UBERON:0011779 ! nerve of head region intersection_of: UBERON:0001021 ! nerve intersection_of: RO:0002134 UBERON:0001605 ! innervates ciliary muscle intersection_of: RO:0002134 UBERON:0001769 ! innervates iris intersection_of: RO:0002134 UBERON:0012430 ! innervates tunica fibrosa of eyeball intersection_of: RO:0002380 UBERON:0002058 ! branching part of main ciliary ganglion relationship: RO:0002134 UBERON:0001605 ! innervates ciliary muscle relationship: RO:0002134 UBERON:0012430 ! innervates tunica fibrosa of eyeball relationship: RO:0002380 UBERON:0002058 ! branching part of main ciliary ganglion property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0022303 name: nervous system cell part layer def: "Single layer of a laminar structure, identified by different density, arrangement or size of cells and processes arranged in flattened layers or lamina[CUMBO]." [NLX:149357] subset: cumbo synonym: "lamina" BROAD [CUMBO:CUMBO] synonym: "layer" BROAD [CUMBO:CUMBO] xref: NLX:149357 is_a: UBERON:0005162 ! multi cell part structure intersection_of: UBERON:0005162 ! multi cell part structure intersection_of: BFO:0000050 UBERON:0001016 ! part of nervous system intersection_of: RO:0000086 PATO:0002124 ! has quality laminar relationship: BFO:0000050 UBERON:0001016 ! part of nervous system relationship: RO:0000086 PATO:0002124 ! has quality laminar property_value: IAO:0000116 "this is currently used to group some cellular layers that may not strictly conform to the CARO definition of cell-part layer. Consider genericisizing and introducing subtypes for cellular layer, fibrous layer and cell soma layer" xsd:string property_value: skos:prefLabel "nervous system cell part layer" xsd:string [Term] id: UBERON:0022315 name: primary motor cortex layer 5 synonym: "primary motor cortex lamina V" RELATED [NLX:144263] synonym: "primary motor cortex layer V" RELATED [NLX:144263] xref: NLX:144263 is_a: UBERON:0002301 ! layer of neocortex relationship: BFO:0000050 UBERON:0001384 {source="nlx"} ! part of primary motor cortex relationship: BFO:0000050 UBERON:0005394 {source="nlx"} ! part of cortical layer V [Term] id: UBERON:0022317 name: olfactory cortex layer 1 def: "Surface layer of the olfactory cortex that contains dendrites, fiber systems and a small number of neurons. It has been divided into a superficial part and a deep part." [NLX:152609] synonym: "layer 1 of olfactory cortex" RELATED [NLX:152609] synonym: "olfactory cortex plexiform layer" RELATED [NLX:152609] xref: NLX:152609 is_a: UBERON:0011215 ! central nervous system cell part cluster is_a: UBERON:0022303 ! nervous system cell part layer intersection_of: UBERON:0022303 ! nervous system cell part layer intersection_of: RO:0002007 UBERON:0002894 ! bounding layer of olfactory cortex relationship: BFO:0000051 GO:0030425 ! has part dendrite relationship: BFO:0000051 UBERON:0006134 ! has part nerve fiber relationship: RO:0002007 UBERON:0002894 ! bounding layer of olfactory cortex property_value: skos:prefLabel "olfactory cortex layer 1" xsd:string [Term] id: UBERON:0022318 name: olfactory cortex layer 2 def: "Middle layer of olfactory cortex lying deep to layer 1 and superficial to layer 3, characterized by a compact layer of cell bodies. It can be divided into a superficial part and a deep part." [NLX:152610] synonym: "layer 2 of olfactory cortex" RELATED [NLX:152610] xref: NLX:152610 is_a: UBERON:0011215 ! central nervous system cell part cluster is_a: UBERON:0022303 ! nervous system cell part layer intersection_of: UBERON:0022303 ! nervous system cell part layer intersection_of: BSPO:0001107 UBERON:0022317 ! olfactory cortex layer 1 relationship: BFO:0000050 UBERON:0002894 {source="nlx"} ! part of olfactory cortex relationship: BSPO:0001107 UBERON:0022317 ! olfactory cortex layer 1 relationship: RO:0002473 GO:0043025 ! composed primarily of neuronal cell body property_value: skos:prefLabel "olfactory cortex layer 2" xsd:string [Term] id: UBERON:0022320 name: dorsal cochlear nucleus pyramidal cell layer xref: NLX:153848 is_a: UBERON:0011215 ! central nervous system cell part cluster is_a: UBERON:0022303 ! nervous system cell part layer intersection_of: UBERON:0022303 ! nervous system cell part layer intersection_of: BFO:0000050 UBERON:0002829 ! part of dorsal cochlear nucleus intersection_of: RO:0002473 CL:0000598 ! composed primarily of pyramidal neuron relationship: BFO:0000050 UBERON:0002829 ! part of dorsal cochlear nucleus relationship: RO:0002473 CL:0000598 ! composed primarily of pyramidal neuron property_value: skos:prefLabel "dorsal cochlear nucleus pyramidal cell layer" xsd:string [Term] id: UBERON:0022350 name: visceral serous membrane def: "Serous membrane layer that is adjacent to and lines an organ." [http://orcid.org/0000-0002-6601-2165] synonym: "visceral wall of serous membrane" EXACT [FMA:15860] xref: FMA:15860 is_a: UBERON:0004923 ! organ component layer intersection_of: UBERON:0004923 ! organ component layer intersection_of: BFO:0000050 UBERON:0000042 ! part of serous membrane intersection_of: RO:0002220 UBERON:0000062 ! adjacent to organ relationship: BFO:0000050 UBERON:0000042 ! part of serous membrane relationship: RO:0002220 UBERON:0000062 ! adjacent to organ property_value: skos:prefLabel "visceral serous membrane" xsd:string [Term] id: UBERON:0022351 name: parietal serous membrane def: "Serous membrane layer that lines to a body cavity." [http://orcid.org/0000-0002-6601-2165] synonym: "cavity lining" BROAD [MA:0002448] synonym: "parietal wall of serous membrane" EXACT [FMA:15859] xref: FMA:15859 xref: MA:0002448 is_a: UBERON:0004923 ! organ component layer intersection_of: UBERON:0004923 ! organ component layer intersection_of: BFO:0000050 UBERON:0000042 ! part of serous membrane intersection_of: RO:0002220 UBERON:0002553 ! adjacent to anatomical cavity relationship: BFO:0000050 UBERON:0000042 ! part of serous membrane relationship: RO:0002220 UBERON:0002553 ! adjacent to anatomical cavity property_value: skos:prefLabel "parietal serous membrane" xsd:string [Term] id: UBERON:0022355 name: basal layer of endometrium def: "The layer of endometrial epithelium adjacent to the uterine cavity." [Wikipedia:Endometrium#Histology] subset: human_reference_atlas synonym: "pars basalis of endometrium" EXACT [] synonym: "stratum basalis of endometrium" EXACT [FMA:86492] xref: FMA:86492 xref: NCIT:C32189 is_a: UBERON:0004811 ! endometrium epithelium intersection_of: UBERON:0004811 ! endometrium epithelium intersection_of: RO:0002220 UBERON:0013769 ! adjacent to uterine lumen relationship: RO:0002220 UBERON:0013769 ! adjacent to uterine lumen property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0022356 name: outer layer of endometrium def: "The layer of endometrial epithelium adjacent to the myometrium." [Wikipedia:Endometrium#Histology] subset: human_reference_atlas synonym: "functional layer of endometrium" EXACT [FMA:86493] synonym: "stratum functionalis of endometrium" EXACT [FMA:86493] xref: FMA:86493 xref: NCIT:C32642 is_a: UBERON:0004811 ! endometrium epithelium intersection_of: UBERON:0004811 ! endometrium epithelium intersection_of: RO:0002220 UBERON:0001296 ! adjacent to myometrium relationship: RO:0002220 UBERON:0001296 ! adjacent to myometrium property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0022357 name: mesentery of ileum synonym: "ileal mesentery" EXACT [FMA:14652] synonym: "ileum mesentery" EXACT [FMA:14652] synonym: "mesoileum" EXACT [] xref: FMA:14652 is_a: UBERON:0001170 ! mesentery of small intestine intersection_of: UBERON:0002095 ! mesentery intersection_of: BFO:0000050 UBERON:0002116 ! part of ileum relationship: BFO:0000050 UBERON:0002116 ! part of ileum [Term] id: UBERON:0022358 name: placenta blood vessel def: "A blood vessel of the placenta." [GO:0060674] subset: human_reference_atlas synonym: "placental vessel" BROAD [] xref: SCTID:280716005 is_a: UBERON:0001981 ! blood vessel is_a: UBERON:0005156 ! reproductive structure intersection_of: UBERON:0001981 ! blood vessel intersection_of: BFO:0000050 UBERON:0001987 ! part of placenta relationship: BFO:0000050 UBERON:0001987 ! part of placenta property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0022360 name: male mammary gland duct def: "A mammary gland duct that is part of a male organism. This structure typically regresses." [http://orcid.org/0000-0002-6601-2165] is_a: UBERON:0001765 ! mammary duct intersection_of: UBERON:0001765 ! mammary duct intersection_of: BFO:0000050 UBERON:0003101 ! part of male organism relationship: BFO:0000050 UBERON:0003101 ! part of male organism [Term] id: UBERON:0022361 name: lung field def: "A specific region of the foregut into the area in which the lung will develop." [GOC:dph, GOC:mtg_lung] synonym: "lung field" EXACT [] xref: SCTID:34922002 is_a: UBERON:0007688 ! anlage intersection_of: UBERON:0007688 ! anlage intersection_of: RO:0002387 UBERON:0002048 ! has potential to develop into lung relationship: BFO:0000050 UBERON:0003258 ! part of endoderm of foregut relationship: RO:0002387 UBERON:0002048 ! has potential to develop into lung property_value: skos:prefLabel "lung field" xsd:string [Term] id: UBERON:0023879 name: neural system def: "A set of neural structures that subserve a specific function, e.g., visual system." [NLXANAT:090802] synonym: "neural system" EXACT [NLXANAT:090802] xref: NLXANAT:090802 is_a: UBERON:0011216 ! organ system subdivision relationship: BFO:0000050 UBERON:0001016 ! part of nervous system property_value: IAO:0000116 "this class was inherited from NIFSTD as part of the replacement of NIFSTD with Uberon. It may be obsoleted in the future" xsd:string property_value: skos:prefLabel "neural system" xsd:string [Term] id: UBERON:0023934 name: olfactory bulb main glomerular layer def: "The glomerular layer of the main olfactory bulb, lying deep to the olfactory nerve layer. It contains the glomeruli, neuropil rich spheroid structures surrounded by a distinctive shell of small neuros and glial cells (Paxinos, the Rat Nervous System, 2nd ed., Academic Press, 1995)." [NLXANAT:1005011] synonym: "olfactory bulb main glomerular layer" EXACT [NLXANAT:1005011] xref: NLXANAT:1005011 is_a: UBERON:0005377 ! olfactory bulb glomerular layer intersection_of: UBERON:0005377 ! olfactory bulb glomerular layer intersection_of: BFO:0000050 UBERON:0009951 ! part of main olfactory bulb relationship: BFO:0000050 UBERON:0009951 ! part of main olfactory bulb [Term] id: UBERON:0024045 name: white matter of the cerebellar cortex def: "White matter that lies deep to the granular cell layer of the cerebellar cortex. It contains afferents to the cerebellar cortex and axons that run between the cerebellar cortex and the deep cerebellar nuclei." [NLXANAT:20081249] synonym: "white matter of the cerebellar cortex" EXACT HUMAN_PREFERRED [NLXANAT:20081249] xref: NLXANAT:20081249 is_a: UBERON:0019291 ! white matter of metencephalon intersection_of: UBERON:0002316 ! white matter intersection_of: BFO:0000050 UBERON:0002129 ! part of cerebellar cortex relationship: BFO:0000050 UBERON:0002129 ! part of cerebellar cortex property_value: skos:prefLabel "white matter of the cerebellar cortex" xsd:string [Term] id: UBERON:0024090 name: chemoarchitectural part of brain def: "Regional part of an anatomical region that is revealed by the use of a stain that reveals chemoarchitecture." [NLXANAT:20090501] synonym: "chemoarchitectural part" EXACT [NLXANAT:20090501] xref: NLXANAT:20090501 is_a: UBERON:0002616 ! regional part of brain [Term] id: UBERON:0025261 name: thalamic fiber tract synonym: "thalamic fiber tracts" EXACT HUMAN_PREFERRED [BIRNLEX:749] xref: BIRNLEX:749 is_a: UBERON:0011591 ! tract of diencephalon intersection_of: UBERON:0001018 ! axon tract intersection_of: BFO:0000050 UBERON:0001897 ! part of dorsal plus ventral thalamus relationship: BFO:0000050 UBERON:0001897 ! part of dorsal plus ventral thalamus property_value: skos:prefLabel "thalamic fiber tract" xsd:string [Term] id: UBERON:0025525 name: motor system def: "The part of the central nervous system that is involved with movement." [Wikipedia:Motor_system] comment: It consists of the pyramidal and extrapyramidal system synonym: "motor system" EXACT [NLXANAT:090805] xref: NLXANAT:090805 is_a: UBERON:0023879 {source="NIFSTD"} ! neural system property_value: skos:prefLabel "motor system" xsd:string [Term] id: UBERON:0025533 name: proprioceptive system def: "The sensory system for the sense of proprioception." [NLXANAT:090814] synonym: "proprioceptive system" EXACT [NLXANAT:090814] xref: NLXANAT:090814 is_a: UBERON:0023879 ! neural system intersection_of: UBERON:0023879 ! neural system intersection_of: RO:0002215 GO:0019230 ! capable of proprioception relationship: RO:0002215 GO:0019230 ! capable of proprioception property_value: skos:prefLabel "proprioceptive system" xsd:string [Term] id: UBERON:0025736 name: chemoarchitectural part of striatum synonym: "chemoarchitectural part of neostriatum" EXACT [NLXANAT:20090502] xref: NLXANAT:20090502 is_a: UBERON:0024090 ! chemoarchitectural part of brain intersection_of: UBERON:0024090 ! chemoarchitectural part of brain intersection_of: BFO:0000050 UBERON:0002435 ! part of striatum relationship: BFO:0000050 UBERON:0002435 ! part of striatum [Term] id: UBERON:0026246 name: sacral spinal cord white matter subset: human_reference_atlas synonym: "sacral spinal cord white matter" EXACT HUMAN_PREFERRED [BIRNLEX:1500] xref: BIRNLEX:1500 is_a: UBERON:0002318 ! white matter of spinal cord intersection_of: UBERON:0002316 ! white matter intersection_of: BFO:0000050 UBERON:0005843 ! part of sacral spinal cord disjoint_from: UBERON:0029503 {source="NIFSTD"} ! sacral spinal cord gray matter relationship: BFO:0000050 UBERON:0005843 ! part of sacral spinal cord property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0026386 name: lumbar spinal cord white matter subset: human_reference_atlas synonym: "lumbar spinal cord white matter" EXACT HUMAN_PREFERRED [BIRNLEX:1639] xref: BIRNLEX:1639 is_a: UBERON:0002318 ! white matter of spinal cord intersection_of: UBERON:0002316 ! white matter intersection_of: BFO:0000050 UBERON:0002792 ! part of lumbar spinal cord disjoint_from: UBERON:0029636 {source="NIFSTD"} ! lumbar spinal cord gray matter relationship: BFO:0000050 UBERON:0002792 ! part of lumbar spinal cord property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0027331 name: flocculonodular lobe, hemisphere portion synonym: "hemispheric part of the flocculonodular lobe of the cerebellum" EXACT HUMAN_PREFERRED [NLXANAT:20081260] xref: NLXANAT:20081260 is_a: UBERON:0002749 ! regional part of cerebellar cortex intersection_of: UBERON:0002616 ! regional part of brain intersection_of: BFO:0000050 UBERON:0002245 ! part of cerebellar hemisphere intersection_of: BFO:0000050 UBERON:0003012 ! part of flocculonodular lobe relationship: BFO:0000050 UBERON:0002245 ! part of cerebellar hemisphere relationship: BFO:0000050 UBERON:0003012 ! part of flocculonodular lobe property_value: skos:prefLabel "flocculonodular lobe, hemisphere portion" xsd:string [Term] id: UBERON:0027368 name: matrix compartment def: "The larger of two chemoarchitectural compartments identified in the neostriatum through differential staining for various biochemical markers. It usually is identified through differentially high staining for acetylcholinesterase and calbinin D28K." [NLXANAT:20090503] synonym: "matrix" RELATED [NLXANAT:20090503] synonym: "matrix compartment" EXACT [NLXANAT:20090503] xref: NLXANAT:20090503 is_a: UBERON:0025736 {source="NIFSTD"} ! chemoarchitectural part of striatum [Term] id: UBERON:0027371 name: striosome def: "One of two compartments identified in the neostriatum, particularly the caudate nucleus, on the basis of differential staining for several biochemical markers such as acetylcholinesterase and calbindin. In individual sections, the striosomes appear as small patches of differentially high or low staining activity. In three dimensions, they form a 3D labyrinth extending throughout the caudate nucleus and in the putamen." [NLXANAT:20090506] synonym: "striosomal compartment" EXACT [NLXANAT:20090506] synonym: "striosomal part" RELATED [] synonym: "striosome" EXACT [NLXANAT:20090506] xref: NLXANAT:20090506 is_a: UBERON:0025736 {source="NIFSTD"} ! chemoarchitectural part of striatum [Term] id: UBERON:0029001 name: matrix compartment of caudate nucleus def: "Matrix compartment located in the caudate nucleus." [NLXANAT:20090504] synonym: "matrix compartment of caudate nucleus" EXACT [NLXANAT:20090504] xref: NLXANAT:20090504 is_a: UBERON:0027368 ! matrix compartment intersection_of: UBERON:0027368 ! matrix compartment intersection_of: BFO:0000050 UBERON:0001873 ! part of caudate nucleus relationship: BFO:0000050 UBERON:0001873 ! part of caudate nucleus [Term] id: UBERON:0029002 name: matrix compartment of putamen synonym: "matrix compartment of putamen" EXACT [NLXANAT:20090505] xref: NLXANAT:20090505 is_a: UBERON:0027368 ! matrix compartment intersection_of: UBERON:0027368 ! matrix compartment intersection_of: BFO:0000050 UBERON:0001874 ! part of putamen relationship: BFO:0000050 UBERON:0001874 ! part of putamen [Term] id: UBERON:0029004 name: striosomal part of caudate nucleus synonym: "striosomal part of caudate nucleus" EXACT [NLXANAT:20090507] xref: NLXANAT:20090507 is_a: UBERON:0027371 ! striosome intersection_of: UBERON:0027371 ! striosome intersection_of: BFO:0000050 UBERON:0001873 ! part of caudate nucleus relationship: BFO:0000050 UBERON:0001873 ! part of caudate nucleus [Term] id: UBERON:0029005 name: striosomal part of putamen synonym: "striosomal part of putamen" EXACT [NLXANAT:20090508] xref: NLXANAT:20090508 is_a: UBERON:0027371 ! striosome intersection_of: UBERON:0027371 ! striosome intersection_of: BFO:0000050 UBERON:0001874 ! part of putamen relationship: BFO:0000050 UBERON:0001874 ! part of putamen [Term] id: UBERON:0029503 name: sacral spinal cord gray matter subset: human_reference_atlas synonym: "sacral spinal cord gray matter" EXACT HUMAN_PREFERRED [BIRNLEX:1491] xref: BIRNLEX:1491 is_a: UBERON:0002315 ! gray matter of spinal cord intersection_of: UBERON:0002020 ! gray matter intersection_of: BFO:0000050 UBERON:0005843 ! part of sacral spinal cord relationship: BFO:0000050 UBERON:0005843 ! part of sacral spinal cord property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0029636 name: lumbar spinal cord gray matter subset: human_reference_atlas synonym: "lumbar spinal cord gray matter" EXACT HUMAN_PREFERRED [BIRNLEX:1624] xref: BIRNLEX:1624 is_a: UBERON:0002315 ! gray matter of spinal cord intersection_of: UBERON:0002020 ! gray matter intersection_of: BFO:0000050 UBERON:0002792 ! part of lumbar spinal cord relationship: BFO:0000050 UBERON:0002792 ! part of lumbar spinal cord property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0030276 name: lumbar spinal cord ventral horn subset: human_reference_atlas synonym: "lumbar spinal cord anterior horn" RELATED [BIRNLEX:891] synonym: "lumbar spinal cord ventral horn" EXACT HUMAN_PREFERRED [BIRNLEX:891] xref: BIRNLEX:891 is_a: UBERON:0002257 ! ventral horn of spinal cord intersection_of: UBERON:0002257 ! ventral horn of spinal cord intersection_of: BFO:0000050 UBERON:0002792 ! part of lumbar spinal cord relationship: BFO:0000050 UBERON:0029636 ! part of lumbar spinal cord gray matter property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0032748 name: sacral spinal cord ventral horn subset: human_reference_atlas synonym: "sacral spinal cord anterior horn" RELATED [BIRNLEX:1457] synonym: "sacral spinal cord ventral horn" EXACT HUMAN_PREFERRED [BIRNLEX:1457] xref: BIRNLEX:1457 is_a: UBERON:0002257 ! ventral horn of spinal cord intersection_of: UBERON:0002257 ! ventral horn of spinal cord intersection_of: BFO:0000050 UBERON:0005843 ! part of sacral spinal cord relationship: BFO:0000050 UBERON:0029503 ! part of sacral spinal cord gray matter property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0033939 name: sacral spinal cord dorsal horn subset: human_reference_atlas synonym: "sacral spinal cord dorsal horn" EXACT HUMAN_PREFERRED [BIRNLEX:1453] synonym: "sacral spinal cord posterior horn" RELATED [BIRNLEX:1453] xref: BIRNLEX:1453 is_a: UBERON:0002256 ! dorsal horn of spinal cord intersection_of: UBERON:0002256 ! dorsal horn of spinal cord intersection_of: BFO:0000050 UBERON:0005843 ! part of sacral spinal cord relationship: BFO:0000050 UBERON:0029503 ! part of sacral spinal cord gray matter property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0034678 name: forceps minor of corpus callosum synonym: "anterior forceps" EXACT [FMA:61944] synonym: "anterior forceps" RELATED [NeuroNames:192] synonym: "anterior forceps of corpus callosum" EXACT [FMA:61944] synonym: "anterior forceps of the corpus callosum" RELATED [NeuroNames:192] synonym: "corpus callosum, anterior forceps" RELATED [NeuroNames:192] synonym: "corpus callosum, anterior forceps (Arnold)" RELATED [NeuroNames:192] synonym: "corpus callosum, forceps minor" RELATED OMO:0003011 [NeuroNames:192] synonym: "forceps frontalis" EXACT [FMA:TA] synonym: "forceps frontalis" RELATED OMO:0003011 [NeuroNames:192] synonym: "forceps minor" EXACT [FMA:TA] synonym: "forceps minor" RELATED OMO:0003011 [NeuroNames:192] synonym: "forceps minor corporis callosi" RELATED OMO:0003011 [NeuroNames:192] synonym: "forceps minor of corpus callosum" RELATED OMO:0003011 [NeuroNames:192] synonym: "forceps minor of the corpus callosum" RELATED [NeuroNames:192] synonym: "frontal forceps" EXACT [FMA:61944] synonym: "frontal forceps" RELATED [NeuroNames:192] synonym: "minor forceps" EXACT [FMA:61944] xref: DHBA:12024 xref: FMA:61944 xref: neuronames:192 xref: SCTID:369199005 is_a: UBERON:0002437 ! cerebral hemisphere white matter relationship: BFO:0000050 UBERON:0015599 {source="DHBA"} ! part of genu of corpus callosum property_value: skos:prefLabel "forceps minor of corpus callosum" xsd:string [Term] id: UBERON:0034705 name: developing neuroepithelium def: "An embryonic or larval epithelium that is committed to form part of the nervous system." [AEO:0001008, AEO:JB] synonym: "embryonic neuroepithelium" EXACT [http://orcid.org/0000-0002-6601-2165] synonym: "neurepithelium" BROAD [BTO:0000314] synonym: "neuroepithelium" EXACT [AEO:0001008] xref: AEO:0001008 xref: BTO:0000314 xref: EHDAA2_RETIRED:0004654 xref: FMA:64807 is_a: UBERON:0000483 ! epithelium relationship: BFO:0000050 UBERON:0001016 ! part of nervous system property_value: skos:prefLabel "developing neuroepithelium" xsd:string [Term] id: UBERON:0034706 name: proliferating neuroepithelium def: "An epithelium that is undergoing proliferation to provide large numbers of neuronal cells." [AEO:0001009] xref: AEO:0001009 is_a: UBERON:0034705 {source="AEO"} ! developing neuroepithelium property_value: skos:prefLabel "proliferating neuroepithelium" xsd:string [Term] id: UBERON:0034707 name: differentiating neuroepithelium def: "A neuroepithelium some of whose cells are undergoing terminal differentiation to become neuronal cells." [AEO:0001010] xref: AEO:0001010 is_a: BFO:0000002 is_a: UBERON:0034705 {source="AEO"} ! developing neuroepithelium relationship: BFO:0000051 CL:0000031 ! has part neuroblast (sensu Vertebrata) property_value: skos:prefLabel "differentiating neuroepithelium" xsd:string [Term] id: UBERON:0034708 name: cerebellum marginal layer synonym: "marginal zone of cerebellum" EXACT [DHBA:12695] synonym: "MZCB" RELATED OMO:0003000 [DHBA:12695] xref: DHBA:12695 xref: EHDAA2:0001152 xref: EMAPA:17789 is_a: UBERON:0034709 ! hindbrain marginal layer intersection_of: UBERON:0004062 ! neural tube marginal layer intersection_of: BFO:0000050 UBERON:0002037 ! part of cerebellum relationship: BFO:0000050 UBERON:0002037 ! part of cerebellum property_value: skos:prefLabel "cerebellum marginal layer" xsd:string [Term] id: UBERON:0034709 name: hindbrain marginal layer synonym: "marginal zone of hindbrain" EXACT [DHBA:12694] synonym: "MZH" RELATED OMO:0003000 [DHBA:12694] xref: DHBA:12694 xref: EMAPA:32916 is_a: UBERON:0004062 ! neural tube marginal layer is_a: UBERON:0011215 ! central nervous system cell part cluster intersection_of: UBERON:0004062 ! neural tube marginal layer intersection_of: BFO:0000050 UBERON:0002028 ! part of hindbrain relationship: BFO:0000050 UBERON:0002028 ! part of hindbrain property_value: skos:prefLabel "hindbrain marginal layer" xsd:string [Term] id: UBERON:0034710 name: spinal cord ventricular layer synonym: "spinal cord lateral wall ventricular layer" EXACT [EHDAA2:0001267] xref: EHDAA2:0001267 xref: EMAPA:17585 is_a: UBERON:0004060 ! neural tube ventricular layer intersection_of: UBERON:0004060 ! neural tube ventricular layer intersection_of: BFO:0000050 UBERON:0006241 ! part of future spinal cord relationship: BFO:0000050 UBERON:0005496 {source="EHDAA2"} ! part of neural tube lateral wall relationship: BFO:0000050 UBERON:0006241 ! part of future spinal cord property_value: skos:prefLabel "spinal cord ventricular layer" xsd:string [Term] id: UBERON:0034711 name: cortical preplate def: "The layer of the developing cerebral cortex that is formed from the first cohort of neurons to migrate out of the cortical ventricular zone; split by the second wave into marginal zone and subplate." [PMID:12626695] xref: EMAPA:35261 is_a: UBERON:0014950 ! layer of developing cerebral cortex property_value: skos:prefLabel "cortical preplate" xsd:string [Term] id: UBERON:0034713 name: cranial neuron projection bundle def: "Any of the cranial nerves, or their central nervous system analogs (the optic tract, the epiphyseal tract). These analogs are not true nerves, and are instead evaginated sensory afferents emanating from the brain." [http://orcid.org/0000-0002-6601-2165, ISBN:0471888893] subset: human_reference_atlas synonym: "cranial nerve fiber bundle" RELATED [http://orcid.org/0000-0002-6601-2165] synonym: "cranial nerve fiber tract" RELATED [http://orcid.org/0000-0002-6601-2165] synonym: "cranial nerve or tract" RELATED [http://orcid.org/0000-0002-6601-2165] synonym: "neuron projection bundle from brain" RELATED [http://orcid.org/0000-0002-6601-2165] is_a: UBERON:0000122 ! neuron projection bundle is_a: UBERON:0015212 ! lateral structure relationship: BSPO:0000126 UBERON:0000033 ! head relationship: extends_fibers_into UBERON:0000955 ! brain relationship: RO:0002162 NCBITaxon:89593 ! in taxon Craniata property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "cranial neuron projection bundle" xsd:string [Term] id: UBERON:0034714 name: epiphyseal tract def: "A cranial nerve fiber tract that innervates the parietal eye." [ISBN:0471888893] comment: This should be classified as an evaginated sensory afferents rather than cranial nerves, as they are part of the CNS[ISBN:0471888893] synonym: "epiphyseal nerve" RELATED [ISBN:0471888893] is_a: UBERON:0011215 ! central nervous system cell part cluster is_a: UBERON:0034713 ! cranial neuron projection bundle intersection_of: UBERON:0034713 ! cranial neuron projection bundle intersection_of: RO:0002134 UBERON:0015238 ! innervates pineal complex relationship: extends_fibers_into UBERON:0001899 ! epithalamus relationship: RO:0002134 UBERON:0015238 ! innervates pineal complex property_value: skos:prefLabel "epiphyseal tract" xsd:string [Term] id: UBERON:0034715 name: pineal tract def: "A cranial nerve fiber tract that innervates the pineal body." [ISBN:0471888893] comment: This should be classified as an evaginated sensory afferents rather than cranial nerves, as they are part of the CNS[ISBN:0471888893] synonym: "pineal nerve" RELATED [ISBN:0471888893] xref: FMA:77600 is_a: UBERON:0034714 ! epiphyseal tract intersection_of: UBERON:0034713 ! cranial neuron projection bundle intersection_of: RO:0002134 UBERON:0001905 ! innervates pineal body relationship: RO:0002134 UBERON:0001905 ! innervates pineal body relationship: RO:0002380 UBERON:0034714 ! branching part of epiphyseal tract property_value: skos:prefLabel "pineal tract" xsd:string [Term] id: UBERON:0034717 name: integumental taste bud def: "A taste bud that is located external to the digestive tube, on the head or body, as found in species such as goldfish." [http://orcid.org/0000-0002-6601-2165, PMID:11921337] is_a: UBERON:0001727 ! taste bud intersection_of: UBERON:0001727 ! taste bud intersection_of: BFO:0000050 UBERON:0002416 ! part of integumental system relationship: BFO:0000050 UBERON:0002416 ! part of integumental system property_value: skos:prefLabel "integumental taste bud" xsd:string [Term] id: UBERON:0034719 name: lip taste bud def: "A taste bud that is located on a lip." [http://orcid.org/0000-0002-6601-2165, PMID:11921337] is_a: UBERON:0001727 ! taste bud is_a: UBERON:0013765 ! digestive system element intersection_of: UBERON:0001727 ! taste bud intersection_of: BFO:0000050 UBERON:0001833 ! part of lip relationship: BFO:0000050 UBERON:0001833 ! part of lip property_value: RO:0002175 NCBITaxon:32443 property_value: skos:prefLabel "lip taste bud" xsd:string [Term] id: UBERON:0034720 name: head taste bud def: "A taste bud that is located on the skin of the head." [http://orcid.org/0000-0002-6601-2165] is_a: UBERON:0034717 ! integumental taste bud intersection_of: UBERON:0001727 ! taste bud intersection_of: BFO:0000050 UBERON:0001084 ! part of skin of head relationship: BFO:0000050 UBERON:0001084 ! part of skin of head property_value: skos:prefLabel "head taste bud" xsd:string [Term] id: UBERON:0034721 name: pharyngeal taste bud def: "A taste bud that is located in the pharynx." [http://orcid.org/0000-0002-6601-2165] is_a: UBERON:0001727 ! taste bud is_a: UBERON:0013765 ! digestive system element intersection_of: UBERON:0001727 ! taste bud intersection_of: BFO:0000050 UBERON:0006562 ! part of pharynx relationship: BFO:0000050 UBERON:0000355 ! part of pharyngeal mucosa property_value: RO:0002175 NCBITaxon:7778 property_value: skos:prefLabel "pharyngeal taste bud" xsd:string [Term] id: UBERON:0034722 name: mouth roof taste bud def: "A taste bud that is located on the roof of the mouth." [http://orcid.org/0000-0002-6601-2165] is_a: UBERON:0001727 ! taste bud intersection_of: UBERON:0001727 ! taste bud intersection_of: BFO:0000050 UBERON:0007375 ! part of roof of mouth relationship: BFO:0000050 UBERON:0007375 ! part of roof of mouth property_value: RO:0002175 NCBITaxon:7778 property_value: skos:prefLabel "mouth roof taste bud" xsd:string [Term] id: UBERON:0034724 name: esophageal taste bud def: "A taste bud that is located in the esophagus." [http://orcid.org/0000-0002-6601-2165] is_a: UBERON:0001727 ! taste bud is_a: UBERON:0013765 ! digestive system element intersection_of: UBERON:0001727 ! taste bud intersection_of: BFO:0000050 UBERON:0001043 ! part of esophagus relationship: BFO:0000050 UBERON:0001043 ! part of esophagus property_value: RO:0002175 NCBITaxon:32443 property_value: skos:prefLabel "esophageal taste bud" xsd:string [Term] id: UBERON:0034726 name: trunk taste bud def: "A taste bud that is located on the skin of the trunk." [http://orcid.org/0000-0002-6601-2165] is_a: UBERON:0005177 ! trunk region element is_a: UBERON:0034717 ! integumental taste bud intersection_of: UBERON:0001727 ! taste bud intersection_of: BFO:0000050 UBERON:0001085 ! part of skin of trunk relationship: BFO:0000050 UBERON:0001085 ! part of skin of trunk property_value: skos:prefLabel "trunk taste bud" xsd:string [Term] id: UBERON:0034728 name: autonomic nerve def: "The autonomic nerve is a small nerve which carries postganglionic sympathetic and parasympathetic neurons from the zygomaticotemporal nerve; a branch of the maxillary nerve, to the lacrimal nerve; a branch of the ophthalmic nerve. These neurons derive from the superior cervical ganglion and the pterygopalatine ganglion respectively. They will travel to the lacrimal gland via the lacrimal nerve. Parasympathetic will induce lacrimation and vice versa." [Wikipedia:Autonomic_nerve] subset: human_reference_atlas synonym: "nervus visceralis" EXACT [FMA:5866] synonym: "visceral nerve" EXACT [FMA:5866] xref: EMAPA:37957 {source="MA:th"} xref: FMA:5866 xref: MESH:D017776 xref: SCTID:276145003 xref: Wikipedia:Autonomic_nerve is_a: UBERON:0011779 ! nerve of head region relationship: BFO:0000050 UBERON:0002410 ! part of autonomic nervous system relationship: extends_fibers_into UBERON:0001805 ! autonomic ganglion relationship: RO:0002380 UBERON:0036264 ! branching part of zygomaticotemporal nerve property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "autonomic nerve" xsd:string [Term] id: UBERON:0034729 name: sympathetic nerve subset: human_reference_atlas xref: EMAPA:37958 {source="MA:th"} xref: SCTID:181098007 is_a: UBERON:0001021 ! nerve intersection_of: UBERON:0001021 ! nerve intersection_of: BFO:0000050 UBERON:0000013 ! part of sympathetic nervous system relationship: BFO:0000050 UBERON:0000013 ! part of sympathetic nervous system relationship: extends_fibers_into UBERON:0001806 ! sympathetic ganglion property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "sympathetic nerve" xsd:string [Term] id: UBERON:0034730 name: olfactory tract linking bulb to ipsilateral dorsal telencephalon synonym: "lateral olfactory tract" RELATED [ZFA:0000229] synonym: "tractus olfactorius lateralis" RELATED [ZFA:0000229] xref: TAO:0000229 xref: ZFA:0000229 is_a: UBERON:0002265 ! olfactory tract intersection_of: UBERON:0002265 ! olfactory tract intersection_of: RO:0002131 UBERON:0000203 ! overlaps pallium relationship: RO:0002131 UBERON:0000203 ! overlaps pallium property_value: skos:prefLabel "olfactory tract linking bulb to ipsilateral dorsal telencephalon" xsd:string [Term] id: UBERON:0034763 name: hindbrain commissure def: "Any commissure within the hindbrain." [http://orcid.org/0000-0002-6601-2165, ZFIN:ZDB-PUB-090417-11] xref: TAO:0002199 xref: ZFA:0001692 is_a: UBERON:0005970 ! brain commissure intersection_of: UBERON:0001020 ! nervous system commissure intersection_of: BFO:0000050 UBERON:0002028 ! part of hindbrain relationship: BFO:0000050 UBERON:0002028 ! part of hindbrain property_value: skos:prefLabel "hindbrain commissure" xsd:string [Term] id: UBERON:0034768 name: morphological feature def: "A part of an organism or organ that is continuous with its surroundings and distinguished from its surroundings based on morphology." [http://orcid.org/0000-0002-6601-2165] subset: common_anatomy is_a: UBERON:0000061 ! anatomical structure relationship: BFO:0000050 UBERON:0000468 ! part of multicellular organism relationship: RO:0000086 PATO:0000052 ! has quality shape property_value: RO:0002175 NCBITaxon:33090 property_value: RO:0002175 NCBITaxon:33208 property_value: RO:0002175 NCBITaxon:4751 property_value: skos:prefLabel "morphological feature" xsd:string [Term] id: UBERON:0034769 name: lymphomyeloid tissue xref: FMA:79770 xref: NCIT:C41168 is_a: UBERON:0015757 {source="FMA"} ! heterogeneous tissue [Term] id: UBERON:0034873 name: bodily gas def: "Any substance in the body or expelled from the body that is in a gaseous state." [http://orcid.org/0000-0002-6601-2165] synonym: "gas in anatomical space" EXACT [] synonym: "portion of gas in anatomical space" EXACT [FMA:84580] xref: FMA:84580 is_a: UBERON:0000463 ! organism substance intersection_of: UBERON:0000463 ! organism substance intersection_of: RO:0000086 PATO:0001547 ! has quality quality of a gas relationship: RO:0000086 PATO:0001547 ! has quality quality of a gas property_value: skos:prefLabel "bodily gas" xsd:string [Term] id: UBERON:0034874 name: air in respiratory system def: "Any portion of gas located in a part of the respiratory system that is composed primarily of air." [http://orcid.org/0000-0002-6601-2165] synonym: "respiratory air" EXACT [FMA:84581] synonym: "respiratory system air" EXACT [] xref: FMA:84581 is_a: UBERON:0034947 ! gas in respiratory system intersection_of: UBERON:0034873 ! bodily gas intersection_of: RO:0001025 UBERON:0001004 ! located in respiratory system intersection_of: RO:0002473 CHEBI:25805 ! composed primarily of relationship: RO:0002473 CHEBI:25805 ! composed primarily of property_value: skos:prefLabel "air in respiratory system" xsd:string [Term] id: UBERON:0034875 name: future pituitary gland synonym: "pituitary primordium" EXACT [EHDAA2:0001472] xref: EHDAA2:0001472 xref: EMAPA:32796 is_a: BFO:0000002 is_a: UBERON:0006598 ! presumptive structure intersection_of: UBERON:0006598 ! presumptive structure intersection_of: RO:0002387 UBERON:0000007 ! has potential to develop into pituitary gland relationship: BFO:0000050 UBERON:0000033 {source="EMAPA"} ! part of head relationship: RO:0002202 UBERON:0000924 {source="Wikipedia"} ! develops from ectoderm relationship: RO:0002387 UBERON:0000007 ! has potential to develop into pituitary gland property_value: skos:prefLabel "future pituitary gland" xsd:string [Term] id: UBERON:0034876 name: future neurohypophysis def: "The outgrowth of neuroectoderm located on the floor of the embryonic hypothalamus that gives rise to the neurohypophysis (posterior lobe) of the pituitary gland." [https://sourceforge.net/p/obo/mammalian-phenotype-requests/1930/, MP:0013339] synonym: "neurohypohysial region" RELATED [EHDAA2:0004434] synonym: "neurohypophyseal bud" RELATED [MP:0013339] xref: EHDAA2:0004434 xref: EMAPA:16647 is_a: UBERON:0006598 ! presumptive structure intersection_of: UBERON:0006598 ! presumptive structure intersection_of: RO:0002387 UBERON:0002198 ! has potential to develop into neurohypophysis relationship: BFO:0000050 UBERON:0001894 {source="EMAPA"} ! part of diencephalon relationship: BFO:0000050 UBERON:0034875 {source="EMAPA"} ! part of future pituitary gland relationship: RO:0002387 UBERON:0002198 ! has potential to develop into neurohypophysis property_value: skos:prefLabel "future neurohypophysis" xsd:string [Term] id: UBERON:0034878 name: prechordal mesoderm def: "The area of axial mesoderm that develops into the prechordal plate." [MGI:anna] synonym: "prechordal mesenchyme" EXACT [] is_a: UBERON:0002050 ! embryonic structure intersection_of: UBERON:0005423 ! developing anatomical structure intersection_of: BFO:0000050 UBERON:0003068 ! part of axial mesoderm intersection_of: RO:0002387 UBERON:0003063 ! has potential to develop into prechordal plate relationship: BFO:0000050 UBERON:0003068 ! part of axial mesoderm relationship: RO:0002387 UBERON:0003063 ! has potential to develop into prechordal plate property_value: skos:prefLabel "prechordal mesoderm" xsd:string [Term] id: UBERON:0034901 name: cervical sympathetic nerve trunk def: "The cervical ganglia are paravertebral ganglia of the sympathetic nervous system. These emerging postganglionic nerves synapse with preganglionic nerves from the thoracic spinal cord. They consist of three paravertebral ganglia: superior cervical ganglion middle cervical ganglion inferior cervical ganglion. The inferior ganglion may be fused with the first thoracic ganglion to form a single structure, the stellate ganglion. Nerves emerging from cervical sympathetic ganglia contribute to the cardiac plexus, among other things." [Wikipedia:Cervical_ganglia] synonym: "cervical part of sympathetic trunk" EXACT [FMA:6261] synonym: "cervical sympathetic chain" EXACT [FMA:6261] synonym: "cervical sympathetic trunk" EXACT [FMA:6261] xref: FMA:6261 xref: SCTID:280533000 xref: Wikipedia:Cervical_ganglia is_a: UBERON:0004295 ! sympathetic nerve trunk intersection_of: UBERON:0004295 ! sympathetic nerve trunk intersection_of: BFO:0000050 UBERON:0005434 ! part of cervical region relationship: BFO:0000050 UBERON:0005434 ! part of cervical region [Term] id: UBERON:0034902 name: sacral sympathetic nerve trunk synonym: "pelvic sympathetic nerve trunk" RELATED [MA:0001164] synonym: "pelvic sympathetic trunk" RELATED [] synonym: "sacral part of sympathetic trunk" EXACT [FMA:6264] synonym: "sacral sympathetic chain" EXACT [FMA:6264] synonym: "sacral sympathetic trunk" EXACT [FMA:6264] xref: EMAPA:37656 {source="MA:th"} xref: FMA:6264 xref: MA:0001164 is_a: UBERON:0004295 ! sympathetic nerve trunk intersection_of: UBERON:0004295 ! sympathetic nerve trunk intersection_of: BFO:0000050 UBERON:0005473 ! part of sacral region relationship: BFO:0000050 UBERON:0005473 ! part of sacral region [Term] id: UBERON:0034903 name: left atrium endocardium def: "Endocardium that is part of the left atrium." [http://orcid.org/0000-0002-6601-2165] synonym: "endocardium of left atrium" EXACT [FMA:7286] synonym: "left atrial endocardium" EXACT [] synonym: "left atrium endocardial tissue" RELATED [VHOG:0001226] xref: FMA:7286 xref: SCTID:190064008 xref: VHOG:0001226 is_a: UBERON:0002166 ! endocardium of atrium intersection_of: UBERON:0002165 ! endocardium intersection_of: BFO:0000050 UBERON:0002079 ! part of left cardiac atrium relationship: BFO:0000050 UBERON:0002079 ! part of left cardiac atrium property_value: skos:prefLabel "left atrium endocardium" xsd:string [Term] id: UBERON:0034905 name: gland lumen synonym: "lumen of gland" EXACT [] is_a: UBERON:0000464 ! anatomical space intersection_of: UBERON:0000464 ! anatomical space intersection_of: RO:0002572 UBERON:0002530 ! luminal space of gland relationship: RO:0002572 UBERON:0002530 ! luminal space of gland property_value: skos:prefLabel "gland lumen" xsd:string [Term] id: UBERON:0034907 name: pineal parenchyma def: "Parenchymal tissue that forms the pineal gland." [http://orcid.org/0000-0002-6601-2165] xref: NCIT:C41834 xref: UMLS:C1519088 is_a: UBERON:0005158 ! parenchyma of central nervous system intersection_of: UBERON:0000353 ! parenchyma intersection_of: BFO:0000050 UBERON:0001905 ! part of pineal body relationship: BFO:0000050 UBERON:0001905 ! part of pineal body property_value: skos:prefLabel "pineal parenchyma" xsd:string [Term] id: UBERON:0034908 name: scapular muscle def: "Any of the muscles that are responsible for moving the scapula. In humans these are the levator scapulae, the infraspinatus muscle, the teres major, the teres minor, and the supraspinatus muscle." [HPO:curators] is_a: UBERON:0014892 ! skeletal muscle organ, vertebrate intersection_of: UBERON:0014892 ! skeletal muscle organ, vertebrate intersection_of: RO:0002371 UBERON:0006849 ! attached to scapula relationship: RO:0002371 UBERON:0006849 ! attached to scapula [Term] id: UBERON:0034921 name: multi organ part structure def: "An multicellular anatomical structure that has subparts of multiple organs as a part." [CARO:0020001] subset: common_anatomy synonym: "anatomical cluster" RELATED [CARO:0020001] xref: CARO:0020001 is_a: UBERON:0010000 {source="CARO"} ! multicellular anatomical structure relationship: RO:0002473 UBERON:0000064 ! composed primarily of organ part property_value: RO:0002175 NCBITaxon:33090 property_value: RO:0002175 NCBITaxon:33208 property_value: RO:0002175 NCBITaxon:4751 property_value: skos:prefLabel "multi organ part structure" xsd:string [Term] id: UBERON:0034922 name: cell cluster def: "A cluster of cells, largely surrounded by a morphological boundary." [CARO:0020002] subset: common_anatomy xref: CARO:0020002 xref: FMA:62807 is_a: UBERON:0010000 {source="CARO"} ! multicellular anatomical structure relationship: RO:0002219 UBERON:0000015 ! surrounded by non-material anatomical boundary property_value: RO:0002175 NCBITaxon:33090 property_value: RO:0002175 NCBITaxon:33208 property_value: RO:0002175 NCBITaxon:4751 property_value: skos:prefLabel "cell cluster" xsd:string [Term] id: UBERON:0034923 name: disconnected anatomical group def: "Material anatomical entity consisting of multiple anatomical structures that are not connected to each other." [CARO:0020000] subset: common_anatomy xref: CARO:0020000 xref: FBbt:00007276 {sssom:mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"} is_a: UBERON:0000465 {source="CARO"} ! material anatomical entity relationship: RO:0000086 PATO:0010001 ! has quality disconnected relationship: RO:0002180 UBERON:0000061 ! has component anatomical structure relationship: RO:0002180 UBERON:0000061 {minCardinality="2"} ! has component anatomical structure relationship: RO:0002473 UBERON:0000061 ! composed primarily of anatomical structure property_value: RO:0002175 NCBITaxon:33090 property_value: RO:0002175 NCBITaxon:33208 property_value: RO:0002175 NCBITaxon:4751 property_value: skos:prefLabel "disconnected anatomical group" xsd:string [Term] id: UBERON:0034925 name: anatomical collection def: "A collection of anatomical structures that are alike in terms of their morphology or developmental origin." [http://orcid.org/0000-0002-6601-2165] subset: common_anatomy is_a: UBERON:0000465 ! material anatomical entity relationship: RO:0002351 UBERON:0000061 ! has member anatomical structure property_value: IAO:0000116 "resolve if this should be a subclass of disconnected anatomical group. Some collections (e.g. the skeleton or skull) are arguably connected" xsd:string property_value: RO:0002175 NCBITaxon:33090 property_value: RO:0002175 NCBITaxon:33208 property_value: RO:0002175 NCBITaxon:4751 property_value: skos:prefLabel "anatomical collection" xsd:string [Term] id: UBERON:0034926 name: anatomical row def: "An anatomical collection that is arranged in a line." [http://orcid.org/0000-0002-6601-2165] subset: common_anatomy xref: FBbt:00100152 {sssom:mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"} is_a: UBERON:0034925 ! anatomical collection property_value: IAO:0000116 "resolve if this should be a subclass of or merged with aligned anatomical group." xsd:string property_value: RO:0002175 NCBITaxon:33090 property_value: RO:0002175 NCBITaxon:33208 property_value: RO:0002175 NCBITaxon:4751 [Term] id: UBERON:0034928 name: dorsal surface of penis synonym: "dorsum of penis" EXACT [FMA:19623] synonym: "dorsum penis" EXACT [FMA:TA] xref: FMA:19623 is_a: UBERON:0036215 ! anatomical surface region intersection_of: UBERON:0036215 ! anatomical surface region intersection_of: BSPO:0015101 UBERON:0000989 ! penis relationship: BSPO:0015101 UBERON:0000989 ! penis [Term] id: UBERON:0034929 name: external soft tissue zone def: "A region or zone on the surface of an organism that encompasses skin and any adnexa, down through muscles and bounded by underlying skeletal support structures." [http://orcid.org/0000-0002-6601-2165] is_a: UBERON:0010000 ! multicellular anatomical structure is_a: UBERON:0010314 ! structure with developmental contribution from neural crest relationship: BFO:0000050 UBERON:0000475 ! part of organism subdivision relationship: BFO:0000051 UBERON:0000014 ! has part zone of skin relationship: BFO:0000051 UBERON:0001015 ! has part musculature relationship: BFO:0000051 UBERON:0001021 ! has part nerve relationship: BFO:0000051 UBERON:0002049 ! has part vasculature property_value: skos:prefLabel "external soft tissue zone" xsd:string [Term] id: UBERON:0034932 name: epithelium of biliary system def: "The epithelial layer covering the biliary system. This includes the epithelium of the gallbladder (when present) as well as the intrahepatic and extrahepatic bile ducts." [BTO:0001513, http://orcid.org/0000-0002-6601-2165, MGI:cs] synonym: "biliary epithelium" RELATED [BTO:0001513] synonym: "biliary system epithelium" EXACT [http://orcid.org/0000-0002-6601-2165] synonym: "biliary tract epithelium" RELATED [http://orcid.org/0000-0002-6601-2165] xref: BTO:0001513 is_a: UBERON:0000483 ! epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: BFO:0000050 UBERON:0002294 ! part of biliary system relationship: BFO:0000050 UBERON:0002294 ! part of biliary system property_value: skos:prefLabel "epithelium of biliary system" xsd:string [Term] id: UBERON:0034933 name: layer of smooth muscle tissue def: "Any organ component layer that consists of smooth muscle tissue." [http://orcid.org/0000-0002-6601-2165] is_a: UBERON:0018260 ! layer of muscle tissue intersection_of: UBERON:0004923 ! organ component layer intersection_of: RO:0002473 UBERON:0001135 ! composed primarily of smooth muscle tissue relationship: RO:0002473 UBERON:0001135 ! composed primarily of smooth muscle tissue property_value: skos:prefLabel "layer of smooth muscle tissue" xsd:string [Term] id: UBERON:0034940 name: venous sinus cavity def: "An enlarged chamber in the blood sinus capable of accumulating a large volume of blood." [GOC:YMB, ZFA:0007073] synonym: "blood sinus cavity" EXACT [ZFA:0007073] synonym: "blood sinus lumen" EXACT [ZFA:0007073] xref: ZFA:0007073 is_a: UBERON:0010161 ! lumen of blood vessel intersection_of: UBERON:0000464 ! anatomical space intersection_of: RO:0002572 UBERON:0006615 ! luminal space of venous sinus relationship: RO:0002572 UBERON:0006615 ! luminal space of venous sinus [Term] id: UBERON:0034944 name: zone of organ synonym: "organ region with floating fiat boundary" RELATED [FMA:55268] synonym: "organ sector" EXACT [FMA:55268] synonym: "organ zonal region" EXACT [] synonym: "organ zone" EXACT [FMA:55268] xref: FMA:55268 is_a: UBERON:0000064 ! organ part property_value: skos:prefLabel "zone of organ" xsd:string [Term] id: UBERON:0034945 name: excreted gas def: "Any gaseous product of an excretory process." [http://orcid.org/0000-0002-6601-2165] is_a: UBERON:0000174 ! excreta is_a: UBERON:0034873 ! bodily gas intersection_of: UBERON:0034873 ! bodily gas intersection_of: RO:0002353 GO:0007588 ! output of excretion property_value: skos:prefLabel "excreted gas" xsd:string [Term] id: UBERON:0034946 name: gas excreted from digestive tract def: "Any excreted gas that is produced by the digestive tract." [http://orcid.org/0000-0002-6601-2165] comment: In mammals, mostly produced as a byproduct of bacterial fermentation in the gastrointestinal (GI) tract, especially the colon, and excreted through the rectum synonym: "flatulence" NARROW [FMA:78440] synonym: "flatus" NARROW OMO:0003011 [Wikipedia:Flatulence] synonym: "intestinal gas" NARROW [] xref: FMA:78440 is_a: UBERON:0034945 ! excreted gas intersection_of: UBERON:0034945 ! excreted gas intersection_of: RO:0003001 UBERON:0001555 ! produced by digestive tract relationship: RO:0003001 UBERON:0001555 ! produced by digestive tract property_value: skos:prefLabel "gas excreted from digestive tract" xsd:string [Term] id: UBERON:0034947 name: gas in respiratory system def: "Any portion of gas located in a part of the respiratory system." [http://orcid.org/0000-0002-6601-2165] synonym: "respiratory gas" EXACT [] synonym: "respiratory system gas" EXACT [] is_a: UBERON:0034873 ! bodily gas intersection_of: UBERON:0034873 ! bodily gas intersection_of: RO:0001025 UBERON:0001004 ! located in respiratory system relationship: RO:0001025 UBERON:0001004 ! located in respiratory system property_value: skos:prefLabel "gas in respiratory system" xsd:string [Term] id: UBERON:0034953 name: embryonic lymph sac def: "A population of lymphatic endothelial cell precursors that will form the lymph vessels." [DOI:10.1152/japplphysiol.00201.2013, https://github.com/obophenotype/uberon/issues/1383] synonym: "primary lymph sac" RELATED [] xref: NCIT:C34262 xref: UMLS:C1514424 is_a: UBERON:0005291 ! embryonic tissue is_a: UBERON:0007499 ! epithelial sac relationship: BFO:0000050 UBERON:0006558 {source="VHOG"} ! part of lymphatic part of lymphoid system [Term] id: UBERON:0034969 name: epithelial layer of duct synonym: "duct epithelium" RELATED [] synonym: "ductal epithelium" RELATED [] xref: NCIT:C25787 xref: UMLS:C1512086 is_a: UBERON:0003914 ! epithelial tube intersection_of: UBERON:0000483 ! epithelium intersection_of: BFO:0000050 UBERON:0000058 ! part of duct relationship: BFO:0000050 UBERON:0000058 ! part of duct property_value: skos:prefLabel "epithelial layer of duct" xsd:string [Term] id: UBERON:0034978 name: paraganglion (generic) def: "A cluster of neuroendocrine cells derived from neural crest. Paraganglia may be chromaffin or nonchromaffin." [http://orcid.org/0000-0002-6601-2165, Wikipedia:Paraganglion] synonym: "paraganglia" RELATED OMO:0003004 [] xref: FMA:15648 xref: SCTID:281695005 xref: Wikipedia:Paraganglion is_a: UBERON:0010001 {source="cjm"} ! cell cluster organ is_a: UBERON:0010313 ! neural crest-derived structure relationship: RO:0002473 CL:0000165 {source="Wikipedia"} ! composed primarily of neuroendocrine cell property_value: IAO:0000116 "corresponding portion of CL needs fixed" xsd:string [Term] id: UBERON:0034994 name: hindbrain cortical intermediate zone synonym: "hindbrain mantle layer" EXACT [EMAPA:32917] xref: DHBA:12682 xref: EMAPA:32917 is_a: UBERON:0004040 ! cortical intermediate zone intersection_of: UBERON:0004040 ! cortical intermediate zone intersection_of: BFO:0000050 UBERON:0002028 ! part of hindbrain relationship: BFO:0000050 UBERON:0002028 ! part of hindbrain property_value: skos:prefLabel "hindbrain cortical intermediate zone" xsd:string [Term] id: UBERON:0034995 name: jaw mesenchyme def: "Mesenchyme that is part of a developing jaw [Automatically generated definition]." [OBOL:automatic] xref: EMAPA:32907 xref: EMAPA:35454 is_a: UBERON:0003104 ! mesenchyme intersection_of: UBERON:0003104 ! mesenchyme intersection_of: BFO:0000050 UBERON:0011595 ! part of jaw region relationship: BFO:0000050 UBERON:0011595 ! part of jaw region property_value: skos:prefLabel "jaw mesenchyme" xsd:string [Term] id: UBERON:0034996 name: outer renal medulla loop of Henle synonym: "loop of Henle, outer medullary portion" EXACT [EMAPA:28322] xref: EMAPA:28322 is_a: UBERON:0034997 ! renal medulla loop of Henle intersection_of: UBERON:0001288 ! loop of Henle intersection_of: BFO:0000050 UBERON:0001293 ! part of outer medulla of kidney relationship: BFO:0000050 UBERON:0001293 ! part of outer medulla of kidney [Term] id: UBERON:0034997 name: renal medulla loop of Henle synonym: "loop of Henle of renal medulla" EXACT [EMAPA:35460] synonym: "loop of Henle, medullary portion" EXACT [] xref: EMAPA:35460 is_a: UBERON:0001288 ! loop of Henle intersection_of: UBERON:0001288 ! loop of Henle intersection_of: BFO:0000050 UBERON:0000362 ! part of renal medulla relationship: BFO:0000050 UBERON:0000362 ! part of renal medulla [Term] id: UBERON:0035004 name: preputial swelling xref: EMAPA:35702 is_a: UBERON:0002050 ! embryonic structure relationship: BFO:0000050 UBERON:0005876 {source="EMAPA"} ! part of undifferentiated genital tubercle [Term] id: UBERON:0035005 name: preputial swelling of male synonym: "prepuce of male" RELATED [EMAPA:29220] xref: EMAPA:29220 is_a: UBERON:0035004 ! preputial swelling intersection_of: UBERON:0035004 ! preputial swelling intersection_of: BFO:0000050 UBERON:0003101 ! part of male organism relationship: BFO:0000050 UBERON:0006261 {source="EMAPA"} ! part of male genital tubercle [Term] id: UBERON:0035006 name: preputial swelling of female synonym: "prepuce of female" RELATED [EMAPA:30478] xref: EMAPA:30478 is_a: UBERON:0035004 ! preputial swelling intersection_of: UBERON:0035004 ! preputial swelling intersection_of: BFO:0000050 UBERON:0003100 ! part of female organism relationship: BFO:0000050 UBERON:0006233 {source="EMAPA"} ! part of female genital tubercle [Term] id: UBERON:0035014 name: functional part of brain def: "A brain region defined by functional criteria, e.g. auditory cortex, rather than by structural or histological criteria." [NLX:155513] xref: NLX:155513 is_a: UBERON:0002616 {source="NIFSTD"} ! regional part of brain property_value: skos:prefLabel "functional part of brain" xsd:string [Term] id: UBERON:0035020 name: left vagus X nerve trunk synonym: "anterior vagus X nerve trunk" RELATED [MA:0001151] synonym: "left vagus neural trunk" EXACT [FMA:18157] synonym: "trunk of left vagus" EXACT [FMA:18157] xref: EMAPA:37798 {source="MA:th"} xref: FMA:18157 xref: MA:0001151 is_a: UBERON:0003535 ! vagus X nerve trunk is_a: UBERON:0015212 ! lateral structure intersection_of: UBERON:0003535 ! vagus X nerve trunk intersection_of: BSPO:0000120 UBERON:0001016 ! nervous system relationship: BSPO:0000120 UBERON:0001016 ! nervous system [Term] id: UBERON:0035021 name: right vagus X nerve trunk synonym: "posterior vagus X nerve trunk" RELATED [MA:0001152] synonym: "right vagus neural trunk" EXACT [FMA:18151] synonym: "trunk of right vagus" EXACT [FMA:18151] xref: EMAPA:37799 {source="MA:th"} xref: FMA:18151 xref: MA:0001152 is_a: UBERON:0003535 ! vagus X nerve trunk is_a: UBERON:0015212 ! lateral structure intersection_of: UBERON:0003535 ! vagus X nerve trunk intersection_of: BSPO:0000121 UBERON:0001016 ! nervous system relationship: BSPO:0000121 UBERON:0001016 ! nervous system [Term] id: UBERON:0035034 name: eyelid epithelium def: "An epithelium that is part of an eyelid [Automatically generated definition]." [OBOL:automatic] xref: EMAPA:32758 xref: MA:0003163 is_a: UBERON:0015808 ! eye epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: BFO:0000050 UBERON:0001711 ! part of eyelid relationship: BFO:0000050 UBERON:0001711 ! part of eyelid [Term] id: UBERON:0035036 name: naris epithelium def: "An epithelium that is part of a naris [Automatically generated definition]." [OBOL:automatic] xref: EMAPA:35959 xref: MA:0003172 is_a: UBERON:0000483 ! epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: BFO:0000050 UBERON:0000003 ! part of naris relationship: BFO:0000050 UBERON:0000003 ! part of naris [Term] id: UBERON:0035037 name: jaw epithelium xref: EMAPA:32904 xref: MA:0003220 is_a: UBERON:0003929 ! digestive tract epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: BFO:0000050 UBERON:0011595 ! part of jaw region relationship: BFO:0000050 UBERON:0011595 ! part of jaw region property_value: skos:prefLabel "jaw epithelium" xsd:string [Term] id: UBERON:0035039 name: rectal artery synonym: "hemorrhoidal artery" EXACT [] xref: SCTID:277967008 is_a: UBERON:0001637 ! artery intersection_of: UBERON:0001637 ! artery intersection_of: RO:0020101 UBERON:0001052 ! vessel supplies blood to rectum relationship: RO:0020101 UBERON:0001052 ! vessel supplies blood to rectum property_value: skos:prefLabel "rectal artery" xsd:string [Term] id: UBERON:0035044 name: olfactory cortex layer 3 def: "Deepest layer of olfactory cortex." [NLX:152611] xref: NLX:152611 is_a: UBERON:0011215 ! central nervous system cell part cluster is_a: UBERON:0022303 ! nervous system cell part layer intersection_of: UBERON:0022303 ! nervous system cell part layer intersection_of: BSPO:0001107 UBERON:0022318 ! olfactory cortex layer 2 relationship: BFO:0000050 UBERON:0002894 {source="nlx"} ! part of olfactory cortex relationship: BSPO:0001107 UBERON:0022318 ! olfactory cortex layer 2 relationship: RO:0002131 UBERON:0014283 {source="NIFSTD"} ! overlaps piriform cortex layer 3 property_value: skos:prefLabel "olfactory cortex layer 3" xsd:string [Term] id: UBERON:0035045 name: parotid gland intralobular duct def: "Any of the tubular canals of the parotid gland located within the parenchymal (secretory) tissue i.e. within lobules; both intercalated and striated (secretory) ducts are intralobular ducts." [MP:0013746] subset: human_reference_atlas is_a: UBERON:0001837 ! duct of salivary gland is_a: UBERON:0014719 ! intralobular duct intersection_of: UBERON:0014719 ! intralobular duct intersection_of: BFO:0000050 UBERON:0001831 ! part of parotid gland relationship: BFO:0000050 UBERON:0001831 ! part of parotid gland property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0035046 name: parotid gland intercalated duct def: "Any of the small intralobular tubular canal that leads directly from the serous acinus of the parotid gland to a striated (secretory) duct; in mouse, the intercalated ducts are short and narrow and are lined by low cuboidal epithelial cells with large central nuclei; they secrete bicarbonate ion into and absorb chloride ion from the acinar product." [MP:0013747] subset: human_reference_atlas is_a: UBERON:0014727 ! intercalated duct of salivary gland is_a: UBERON:0035045 ! parotid gland intralobular duct intersection_of: UBERON:0014725 ! intercalated duct intersection_of: BFO:0000050 UBERON:0001831 ! part of parotid gland property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0035047 name: parotid gland striated duct def: "Any of the intralobular secretory duct of the parotid gland which connects an intercalated duct to an interlobular excretory duct; striated ducts are lined by cuboidal to columnar acidophilic cells and are so-named because of characteristic striations in the basal portions of the cells which are due to the alignment of mitochondria between deep infoldings of the basal cell membrane; the nucleus is in the central part of the cell above the striations; as they approach the excretory ducts, their diameter may exceed that of the acini; striated ducts reabsorb sodium and secrete potassium." [MP:0013748] subset: human_reference_atlas is_a: UBERON:0014729 ! striated duct of salivary gland is_a: UBERON:0035045 ! parotid gland intralobular duct intersection_of: UBERON:0014729 ! striated duct of salivary gland intersection_of: BFO:0000050 UBERON:0001831 ! part of parotid gland property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0035048 name: parotid gland excretory duct def: "Any of the interlobular excretory ducts of the parotid gland which are found in the connective tissue septa and formed by the union of several intralobular striated (secretory) ducts; ultimately, the excretory ducts of the parotid gland coalesce and form a single main excretory duct (Stensen's duct) that opens into the oral cavity; excretory ducts do not change the secretory product." [MP:0013750] subset: human_reference_atlas is_a: UBERON:0035049 ! excretory duct of salivary gland intersection_of: UBERON:0035050 ! excretory duct intersection_of: BFO:0000050 UBERON:0001831 ! part of parotid gland relationship: BFO:0000050 UBERON:0001831 ! part of parotid gland property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0035049 name: excretory duct of salivary gland def: "Any of the interlobular excretory ducts of a salivary gland which are found in the connective tissue septa and formed by the union of several intralobular striated (secretory) ducts[MP,generalized]." [MP:0013750] xref: FMA:60052 is_a: UBERON:0001837 ! duct of salivary gland is_a: UBERON:0035050 ! excretory duct intersection_of: UBERON:0035050 ! excretory duct intersection_of: BFO:0000050 UBERON:0001044 ! part of saliva-secreting gland [Term] id: UBERON:0035050 name: excretory duct is_a: UBERON:0000058 ! duct property_value: skos:prefLabel "excretory duct" xsd:string [Term] id: UBERON:0035053 name: interlobular duct of salivary gland xref: FMA:60053 is_a: UBERON:0014716 ! interlobular duct is_a: UBERON:0035049 ! excretory duct of salivary gland intersection_of: UBERON:0014716 ! interlobular duct intersection_of: BFO:0000050 UBERON:0001044 ! part of saliva-secreting gland [Term] id: UBERON:0035073 name: duct of eccrine sweat gland def: "A duct made up of simple tubular epithelium that is part of an eccrine sweat gland. The main function of the duct of the eccrine sweat gland is the reabsorption of Na and Cl ions as sweat flows through the duct. It has two cell layers: basal and luminal. It is continuous with the secretory coil and goes towards the skin surface. The distal segment of the duct is relatively straight and connects with the acrosyringium in the epidermis. Most of the ion reabsorption occurs in the proximal part of the duct." [PMID:31608304] synonym: "ductal part of eccrine sweat gland" EXACT [FMA:70617] xref: FMA:70617 is_a: UBERON:0000058 ! duct intersection_of: UBERON:0000058 ! duct intersection_of: BFO:0000050 UBERON:0000423 ! part of eccrine sweat gland relationship: BFO:0000050 UBERON:0000423 ! part of eccrine sweat gland [Term] id: UBERON:0035074 name: duct of apocrine sweat gland synonym: "ductal part of apocrine sweat gland" EXACT [FMA:70643] xref: FMA:70643 is_a: UBERON:0000058 ! duct intersection_of: UBERON:0000058 ! duct intersection_of: BFO:0000050 UBERON:0000382 ! part of apocrine sweat gland relationship: BFO:0000050 UBERON:0000382 ! part of apocrine sweat gland [Term] id: UBERON:0035076 name: parotid gland myoepithelium def: "Epithelium that consists of stellate-shaped contractile cells with long dendritic processes that surround the secretory acini and intercalated ducts of the parotid gland, usually found in the glandular epithelium as a thin layer above the basement membrane but generally beneath the luminal cells; they display features of both smooth muscle and epithelium, such as numerous microfilaments with focal densities in the cytoplasmic processes, and desmosomes which attach them to the epithelial cells; their functions include contraction when the gland is stimulated to secrete, compressing or reinforcing the underlying parenchymal cells, thus aiding in the expulsion of saliva and preventing damage to the other cells." [MGI:anna] subset: human_reference_atlas xref: EMAPA:37934 {source="MA:th"} is_a: UBERON:0000420 ! myoepithelium is_a: UBERON:0003360 ! epithelium of parotid gland intersection_of: UBERON:0000420 ! myoepithelium intersection_of: BFO:0000050 UBERON:0001831 ! part of parotid gland property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0035078 name: parotid gland interlobular duct def: "Any of the excretory ducts of the parotid gland which are found in the connective tissue septa i.e. between lobules." [MP:0013749] subset: human_reference_atlas is_a: UBERON:0035048 ! parotid gland excretory duct is_a: UBERON:0035053 ! interlobular duct of salivary gland intersection_of: UBERON:0014716 ! interlobular duct intersection_of: BFO:0000050 UBERON:0001831 ! part of parotid gland property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0035083 name: transverse process-bearing vertebra def: "A vertebra that has a transverse process." [http://orcid.org/0000-0002-6601-2165] synonym: "pygal vertebra" RELATED [PMID:22753107] synonym: "TP vertebra" RELATED [PMID:22753107] is_a: UBERON:0002412 ! vertebra intersection_of: UBERON:0002412 ! vertebra intersection_of: BFO:0000051 UBERON:0001077 ! has part transverse process of vertebra relationship: BFO:0000051 UBERON:0001077 ! has part transverse process of vertebra [Term] id: UBERON:0035091 name: extrinsic post-anal tail muscle def: "A post-anal tail that attaches outside the tail." [http://orcid.org/0000-0002-6601-2165] is_a: UBERON:0003665 ! post-anal tail muscle intersection_of: UBERON:0003665 ! post-anal tail muscle intersection_of: RO:0002371 UBERON:0010742 ! attached to bone of pelvic complex relationship: RO:0002371 UBERON:0010742 ! attached to bone of pelvic complex [Term] id: UBERON:0035102 name: transverse process of caudal vertebra def: "A transverse process that is part of a caudal vertebra." [http://orcid.org/0000-0002-6601-2165] is_a: UBERON:0001077 ! transverse process of vertebra intersection_of: UBERON:0001077 ! transverse process of vertebra intersection_of: BFO:0000050 UBERON:0001095 ! part of caudal vertebra relationship: BFO:0000050 UBERON:0001095 ! part of caudal vertebra [Term] id: UBERON:0035109 name: plantar nerve def: "A nerve that innervates the sole of the foot. Planar nerves arise from the posterior branch of the tibial nerve." [http://orcid.org/0000-0002-6601-2165, Wikipedia:Plantar_nerve] comment: Divided into medial and plantar based on the location of the foot supplied synonym: "nerve, plantar" RELATED [] xref: https://upload.wikimedia.org/wikipedia/commons/thumb/1/16/Gray834.svg/180px-Gray834.svg.png xref: NCIT:C77674 xref: SCTID:181074000 xref: UMLS:C0446824 xref: Wikipedia:Plantar_nerve is_a: UBERON:0003431 ! leg nerve intersection_of: UBERON:0001021 ! nerve intersection_of: RO:0002134 UBERON:0008338 ! innervates plantar part of pes relationship: RO:0002134 UBERON:0008338 ! innervates plantar part of pes relationship: RO:0002380 UBERON:0001323 ! branching part of tibial nerve [Term] id: UBERON:0035118 name: material entity in digestive tract def: "Any material entity that is located in the digestive tract. This includes undigested food and liquid as well as unexcreted waste products. It also includes other entities such as ingested stones used to aid digestion. Any microbial cells or cell populations are also included." [https://github.com/EnvironmentOntology/envo/issues/110] synonym: "digestive tract contents" EXACT OMO:0003004 [] synonym: "ingested material entity" RELATED [] is_a: UBERON:0000061 ! anatomical structure intersection_of: UBERON:0000061 ! anatomical structure intersection_of: RO:0001025 UBERON:0006909 ! located in lumen of digestive tract relationship: RO:0001025 UBERON:0006909 ! located in lumen of digestive tract property_value: IAO:0000116 "Note that we treat any material entity that is ingested as an anatomical structure by defintion, although this may be expanding the CARO usage somewhat" xsd:string property_value: skos:prefLabel "material entity in digestive tract" xsd:string [Term] id: UBERON:0035128 name: manus cartilage element synonym: "hand cartilage condensation" EXACT [EMAPA:32631] xref: EMAPA:32631 is_a: UBERON:0010883 ! forelimb cartilage element is_a: UBERON:0015064 ! autopod cartilage intersection_of: UBERON:0015063 ! autopod endochondral element intersection_of: BFO:0000050 UBERON:0002398 ! part of manus intersection_of: RO:0002473 UBERON:0002418 ! composed primarily of cartilage tissue relationship: BFO:0000050 UBERON:0002398 ! part of manus relationship: RO:0002202 UBERON:0009523 {source="EMAPA-modified"} ! develops from mesenchyme of handplate [Term] id: UBERON:0035129 name: pes cartilage element synonym: "foot cartilage condensation" EXACT [EMAPA:32657] xref: EMAPA:32657 is_a: UBERON:0010885 ! hindlimb cartilage element is_a: UBERON:0015064 ! autopod cartilage intersection_of: UBERON:0015063 ! autopod endochondral element intersection_of: BFO:0000050 UBERON:0002387 ! part of pes intersection_of: RO:0002473 UBERON:0002418 ! composed primarily of cartilage tissue relationship: BFO:0000050 UBERON:0002387 ! part of pes relationship: RO:0002202 UBERON:0003328 {source="EMAPA-modified"} ! develops from mesenchyme of footplate [Term] id: UBERON:0035130 name: auditory ossicle endochondral element synonym: "auditory skeletal element" EXACT [] synonym: "ear ossicle element" RELATED [] synonym: "ear ossicles element" RELATED OMO:0003004 [] synonym: "middle ear ossicle element" EXACT [MP:0005105] synonym: "middle ear skeletal element" RELATED [] synonym: "ossicle element" BROAD [EMAPA:17824, Wikipedia:Auditory_ossicle] synonym: "ossicle element of ear" RELATED [] synonym: "ossicle element of inner ear" RELATED [] synonym: "ossicular chain element" RELATED OMO:0003004 [] is_a: BFO:0000002 is_a: UBERON:0010363 ! endochondral element relationship: BFO:0000050 UBERON:0001756 {source="MA"} ! part of middle ear relationship: BFO:0000050 UBERON:0008895 {source="PMID:11523816"} ! part of splanchnocranium relationship: RO:0002202 UBERON:0003099 {source="PMID:11237469", source="https://github.com/obophenotype/uberon/wiki/The-neural-crest"} ! develops from cranial neural crest relationship: RO:0002433 UBERON:0001756 ! contributes to morphology of middle ear [Term] id: UBERON:0035131 name: auditory ossicle cartilage element synonym: "ossicle cartilage condensation" EXACT [EMAPA:35979] xref: EMAPA:35979 is_a: UBERON:0011004 ! pharyngeal arch cartilage is_a: UBERON:0035130 ! auditory ossicle endochondral element intersection_of: UBERON:0035130 ! auditory ossicle endochondral element intersection_of: RO:0002473 UBERON:0002418 ! composed primarily of cartilage tissue [Term] id: UBERON:0035132 name: auditory ossicle pre-cartilage element synonym: "ossicle pre-cartilage condensation" EXACT [EMAPA:35982] xref: EMAPA:35982 is_a: UBERON:0035130 ! auditory ossicle endochondral element intersection_of: UBERON:0035130 ! auditory ossicle endochondral element intersection_of: RO:0002473 UBERON:0005866 ! composed primarily of pre-cartilage condensation relationship: RO:0002473 UBERON:0005866 ! composed primarily of pre-cartilage condensation [Term] id: UBERON:0035159 name: entire surface of organism def: "Anatomical surface, which is the external surface of the whole body. Examples: There is only one body surface." [FMA:61695] synonym: "surface of body" EXACT [FMA:61695] xref: FMA:61695 xref: NCIT:C29667 xref: SCTID:261060002 xref: UMLS:C0489451 is_a: BFO:0000004 is_a: UBERON:0006984 ! anatomical surface intersection_of: UBERON:0006984 ! anatomical surface intersection_of: RO:0002221 UBERON:0000468 ! surrounds multicellular organism relationship: RO:0002221 UBERON:0000468 ! surrounds multicellular organism property_value: skos:prefLabel "entire surface of organism" xsd:string [Term] id: UBERON:0035165 name: posterior surface of prostate def: "The flattened aspect of the prostate with a slight furrow facing the rectum and anus." [ncithesaurus:Posterior_Surface_of_the_Prostate] synonym: "facies posterior (prostatae)" EXACT [FMA:19592] synonym: "facies posterior prostatae" EXACT OMO:0003011 [FMA:19592, FMA:TA] synonym: "posterior surface of prostate gland" EXACT [FMA:19592] xref: FMA:19592 xref: NCIT:C13095 xref: SCTID:279697005 xref: UMLS:C0227961 is_a: UBERON:0035480 ! surface of prostate intersection_of: UBERON:0036215 ! anatomical surface region intersection_of: BSPO:0000122 UBERON:0002367 ! prostate gland intersection_of: RO:0002007 UBERON:0002367 ! bounding layer of prostate gland disjoint_from: UBERON:0035523 {source="lexical"} ! anterior surface of prostate relationship: BSPO:0000122 UBERON:0002367 ! prostate gland [Term] id: UBERON:0035174 name: right ear def: "The organ of hearing located on the right side of the head." [ncithesaurus:Right_Ear] xref: FMA:53641 xref: NCIT:C81285 xref: SCTID:368570004 xref: UMLS:C0229298 is_a: UBERON:0001690 ! ear is_a: UBERON:0015212 ! lateral structure intersection_of: UBERON:0001690 ! ear intersection_of: BSPO:0000121 UBERON:0000033 ! head relationship: BSPO:0000121 UBERON:0000033 ! head property_value: skos:prefLabel "right ear" xsd:string [Term] id: UBERON:0035198 name: superficial lymphatic vessel def: "The tubules that carry lymph throughout the body that are just beneath the surface of the skin." [ncithesaurus:Superficial_Lymphatic_Vessel] synonym: "superficial lymph vessel" EXACT [FMA:52011] xref: FMA:52011 xref: NCIT:C33663 xref: SCTID:20315002 xref: UMLS:C1282745 is_a: UBERON:0001473 ! lymphatic vessel intersection_of: UBERON:0001473 ! lymphatic vessel intersection_of: BFO:0000050 UBERON:0035549 ! part of vasculature of integument relationship: BFO:0000050 UBERON:0035549 ! part of vasculature of integument [Term] id: UBERON:0035237 name: branch of internal carotid artery synonym: "internal carotid arterial subdivision" EXACT [FMA:70506] synonym: "subdivision of internal carotid artery" EXACT [FMA:70506] xref: FMA:70506 xref: NCIT:C32837 xref: SCTID:360629008 xref: UMLS:C1182571 is_a: UBERON:0005396 ! carotid artery segment intersection_of: UBERON:0005396 ! carotid artery segment intersection_of: RO:0002252 UBERON:0001532 ! connecting branch of internal carotid artery relationship: RO:0002252 UBERON:0001532 ! connecting branch of internal carotid artery property_value: skos:prefLabel "branch of internal carotid artery" xsd:string [Term] id: UBERON:0035267 name: neck of gallbladder def: "The narrowest portion of the gallbladder and distal to the cystic duct." [ncithesaurus:Gallbladder_Neck] synonym: "cervix of gallbladder" EXACT [FMA:14538] synonym: "gallbladder neck" EXACT [FMA:14538] xref: FMA:14538 xref: NCIT:C32649 xref: SCTID:245394007 xref: UMLS:C0227546 xref: Wikipedia:Neck_of_gallbladder is_a: UBERON:0001560 ! neck of organ intersection_of: UBERON:0001560 ! neck of organ intersection_of: BFO:0000050 UBERON:0002110 ! part of gallbladder relationship: BFO:0000050 UBERON:0002110 ! part of gallbladder [Term] id: UBERON:0035295 name: left ear def: "The organ of hearing located on the left side of the head[ncit,modified]." [http://orcid.org/0000-0002-6601-2165, ncithesaurus:Left_Ear] xref: FMA:53642 xref: NCIT:C81259 xref: SCTID:368592000 xref: UMLS:C0229299 is_a: UBERON:0001690 ! ear is_a: UBERON:0015212 ! lateral structure intersection_of: UBERON:0001690 ! ear intersection_of: BSPO:0000120 UBERON:0000033 ! head relationship: BSPO:0000120 UBERON:0000033 ! head property_value: skos:prefLabel "left ear" xsd:string [Term] id: UBERON:0035316 name: prostatic capsule def: "The membrane the surrounds the prostate gland." [ncithesaurus:Capsule_of_the_Prostate] synonym: "capsule of prostate" EXACT [FMA:19583] synonym: "capsule of prostate gland" EXACT [FMA:19583] xref: FMA:19583 xref: NCIT:C13086 xref: SCTID:279682007 xref: UMLS:C0227963 is_a: UBERON:0003893 ! capsule is_a: UBERON:0005156 ! reproductive structure intersection_of: UBERON:0003893 ! capsule intersection_of: BFO:0000050 UBERON:0002367 ! part of prostate gland relationship: BFO:0000050 UBERON:0002367 ! part of prostate gland [Term] id: UBERON:0035322 name: right common iliac artery subset: human_reference_atlas synonym: "trunk of right common iliac arterial tree" EXACT [FMA:14765] xref: FMA:14765 xref: NCIT:C33474 xref: SCTID:283392005 xref: UMLS:C0226362 is_a: UBERON:0001191 ! common iliac artery is_a: UBERON:0015212 ! lateral structure intersection_of: UBERON:0001191 ! common iliac artery intersection_of: BSPO:0000121 UBERON:0000468 ! multicellular organism relationship: BSPO:0000121 UBERON:0000468 ! multicellular organism property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0035383 name: lateral wall of nasopharynx synonym: "lateral nasopharynx" EXACT [FMA:54908] xref: FMA:54908 xref: NCIT:C12244 xref: SCTID:361937006 xref: UMLS:C0225486 is_a: UBERON:0000328 ! gut wall is_a: UBERON:0015212 ! lateral structure intersection_of: UBERON:0000060 ! anatomical wall intersection_of: BFO:0000050 UBERON:0001728 ! part of nasopharynx intersection_of: BSPO:0000126 UBERON:0001728 ! nasopharynx relationship: BFO:0000050 UBERON:0001728 ! part of nasopharynx relationship: BSPO:0000126 UBERON:0001728 ! nasopharynx [Term] id: UBERON:0035398 name: branch of external carotid artery synonym: "external carotid arterial subdivision" EXACT [FMA:70505] synonym: "subdivision of external carotid artery" EXACT [FMA:70505] xref: FMA:70505 xref: NCIT:C32552 xref: SCTID:244216003 xref: UMLS:C0447038 is_a: UBERON:0001637 ! artery intersection_of: UBERON:0001637 ! artery intersection_of: RO:0002252 UBERON:0001070 ! connecting branch of external carotid artery relationship: RO:0002252 UBERON:0001070 ! connecting branch of external carotid artery property_value: skos:prefLabel "branch of external carotid artery" xsd:string [Term] id: UBERON:0035401 name: posterior wall of nasopharynx synonym: "posterior nasopharynx" EXACT [FMA:54907] xref: FMA:54907 xref: NCIT:C12243 xref: SCTID:361936002 xref: UMLS:C0225484 is_a: UBERON:0000328 ! gut wall intersection_of: UBERON:0000060 ! anatomical wall intersection_of: BFO:0000050 UBERON:0001728 ! part of nasopharynx intersection_of: BSPO:0000122 UBERON:0001728 ! nasopharynx relationship: BFO:0000050 UBERON:0001728 ! part of nasopharynx relationship: BSPO:0000122 UBERON:0001728 ! nasopharynx [Term] id: UBERON:0035403 name: hypophysial artery def: "An artery that supplies the pituitary gland." [http://orcid.org/0000-0002-6601-2165] is_a: UBERON:0001637 ! artery intersection_of: UBERON:0001637 ! artery intersection_of: RO:0020101 UBERON:0000007 ! vessel supplies blood to pituitary gland relationship: RO:0020101 UBERON:0000007 ! vessel supplies blood to pituitary gland property_value: skos:prefLabel "hypophysial artery" xsd:string [Term] id: UBERON:0035428 name: postcapillary venule xref: FMA:63191 xref: NCIT:C33345 xref: SCTID:6216007 xref: UMLS:C0226505 is_a: UBERON:0001979 {source="FMA"} ! venule [Term] id: UBERON:0035431 name: mediastinal pleura def: "The parietal pleura that lines the mediastinum." [ncithesaurus:Mediastinal_Pleura] synonym: "mediastinal part of parietal pleura" EXACT [FMA:9736] synonym: "pars mediastinalis (pleurae)" EXACT [FMA:9736] synonym: "pars mediastinalis pleurae parietalis" EXACT OMO:0003011 [FMA:9736, FMA:TA] xref: FMA:9736 xref: NCIT:C94820 xref: SCTID:362002008 xref: UMLS:C0225789 xref: Wikipedia:Mediastinal_pleura is_a: UBERON:0034944 ! zone of organ relationship: BFO:0000050 UBERON:0002400 {source="FMA"} ! part of parietal pleura relationship: BFO:0000051 UBERON:0003728 {source="FMA"} ! has part mediastinum [Term] id: UBERON:0035435 name: right suprarenal vein def: "A vein that drains blood from the right adrenal gland into the inferior vena cava." [ncithesaurus:Right_Suprarenal_Vein] subset: human_reference_atlas synonym: "vena suprarenalis (adrenalis) dextra" EXACT [FMA:14343] xref: FMA:14343 xref: NCIT:C53131 xref: SCTID:69354005 xref: UMLS:C0226721 is_a: UBERON:0001146 ! suprarenal vein is_a: UBERON:0015212 ! lateral structure intersection_of: UBERON:0001146 ! suprarenal vein intersection_of: BSPO:0000121 UBERON:0000468 ! multicellular organism relationship: BSPO:0000121 UBERON:0000468 ! multicellular organism relationship: RO:0002170 UBERON:0001072 ! connected to inferior vena cava property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0035471 name: posterior surface of kidney synonym: "facies posterior (Ren)" EXACT [FMA:15590] synonym: "facies posterior renis" EXACT OMO:0003011 [FMA:15590, FMA:TA] xref: FMA:15590 xref: NCIT:C32895 xref: SCTID:279376000 xref: UMLS:C0227610 is_a: UBERON:0036215 ! anatomical surface region intersection_of: UBERON:0036215 ! anatomical surface region intersection_of: BSPO:0000122 UBERON:0002113 ! kidney intersection_of: RO:0002007 UBERON:0002113 ! bounding layer of kidney relationship: BSPO:0000122 UBERON:0002113 ! kidney relationship: RO:0002007 UBERON:0002113 ! bounding layer of kidney [Term] id: UBERON:0035480 name: surface of prostate def: "The external portion of the prostate including the anterior, inferolateral, lateral and posterior surfaces." [ncithesaurus:Surface_of_the_Prostate] synonym: "prostatic surface" EXACT [FMA:19590] synonym: "surface of prostate gland" EXACT [FMA:19590] xref: FMA:19590 xref: NCIT:C13091 xref: SCTID:279694003 xref: UMLS:C0426735 is_a: UBERON:0036215 ! anatomical surface region intersection_of: UBERON:0036215 ! anatomical surface region intersection_of: RO:0002007 UBERON:0002367 ! bounding layer of prostate gland relationship: RO:0002007 UBERON:0002367 ! bounding layer of prostate gland [Term] id: UBERON:0035483 name: left suprarenal vein def: "A vein that drains blood from the left adrenal gland into the left renal artery." [ncithesaurus:Left_Suprarenal_Vein] subset: human_reference_atlas xref: FMA:14349 xref: NCIT:C53138 xref: SCTID:85087001 xref: UMLS:C0226709 xref: Wikipedia:Suprarenal_veins is_a: UBERON:0001146 ! suprarenal vein is_a: UBERON:0015212 ! lateral structure intersection_of: UBERON:0001146 ! suprarenal vein intersection_of: BSPO:0000120 UBERON:0000468 ! multicellular organism relationship: BSPO:0000120 UBERON:0000468 ! multicellular organism relationship: RO:0002170 UBERON:0001142 ! connected to left renal vein property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0035523 name: anterior surface of prostate def: "The aspect of the prostate facing the pubic symphysis." [ncithesaurus:Anterior_Surface_of_the_Prostate] synonym: "anterior surface of prostate gland" EXACT [FMA:19591] synonym: "facies anterior (prostatae)" EXACT [FMA:19591] synonym: "facies anterior prostatae" EXACT OMO:0003011 [FMA:19591, FMA:TA] xref: FMA:19591 xref: NCIT:C13089 xref: SCTID:279696001 xref: UMLS:C0227960 is_a: UBERON:0035480 ! surface of prostate intersection_of: UBERON:0036215 ! anatomical surface region intersection_of: BSPO:0000123 UBERON:0002367 ! prostate gland intersection_of: RO:0002007 UBERON:0002367 ! bounding layer of prostate gland relationship: BSPO:0000123 UBERON:0002367 ! prostate gland [Term] id: UBERON:0035529 name: left common iliac artery subset: human_reference_atlas synonym: "trunk of left common iliac arterial tree" EXACT [FMA:14766] xref: FMA:14766 xref: NCIT:C32957 xref: SCTID:283493001 xref: UMLS:C0226363 is_a: UBERON:0001191 ! common iliac artery is_a: UBERON:0015212 ! lateral structure intersection_of: UBERON:0001191 ! common iliac artery intersection_of: BSPO:0000120 UBERON:0000468 ! multicellular organism relationship: BSPO:0000120 UBERON:0000468 ! multicellular organism property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0035539 name: esophageal artery def: "Any of several arteries that arise from the aorta and supply blood to the esophagus." [ncithesaurus:Esophageal_Artery] subset: human_reference_atlas synonym: "aortic esophageal artery" EXACT [FMA:4149] synonym: "oesophageal artery" EXACT [FMA:4149] xref: FMA:4149 xref: NCIT:C32535 xref: SCTID:56548006 xref: UMLS:C0226294 is_a: UBERON:0004573 {source="FMA"} ! systemic artery intersection_of: UBERON:0001637 ! artery intersection_of: RO:0020101 UBERON:0001043 ! vessel supplies blood to esophagus relationship: RO:0002170 UBERON:0002345 ! connected to descending thoracic aorta relationship: RO:0002252 UBERON:0001515 {source="FMA"} ! connecting branch of thoracic aorta relationship: RO:0020101 UBERON:0001043 ! vessel supplies blood to esophagus property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "esophageal artery" xsd:string [Term] id: UBERON:0035545 name: deep lymphatic vessel def: "The tubules that carry lymph throughout the body that are in the interior of the body or limbs." [ncithesaurus:Deep_Lymphatic_Vessel] synonym: "deep lymph vessel" EXACT [FMA:52012] xref: FMA:52012 xref: NCIT:C32439 xref: SCTID:14033005 xref: UMLS:C1282746 is_a: UBERON:0001473 ! lymphatic vessel intersection_of: UBERON:0001473 ! lymphatic vessel intersection_of: BFO:0000050 UBERON:0035551 ! part of deep vasculature relationship: BFO:0000050 UBERON:0035551 ! part of deep vasculature [Term] id: UBERON:0035546 name: uveal vein synonym: "ciliary vein" EXACT [FMA:51797] xref: FMA:51797 xref: SCTID:149683007 is_a: UBERON:0001638 ! vein intersection_of: UBERON:0001638 ! vein intersection_of: RO:0020102 UBERON:0001768 ! vessel drains blood from uvea relationship: RO:0020102 UBERON:0001768 ! vessel drains blood from uvea property_value: skos:prefLabel "uveal vein" xsd:string [Term] id: UBERON:0035548 name: colic artery xref: SCTID:77852007 is_a: UBERON:0001637 ! artery intersection_of: UBERON:0001637 ! artery intersection_of: RO:0020101 UBERON:0001155 ! vessel supplies blood to colon relationship: RO:0020101 UBERON:0001155 ! vessel supplies blood to colon property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/blood-vasculature-female/v1.3/assets/3d-vh-f-blood-vasculature.glb" xsd:anyURI property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/blood-vasculature-male/v1.3/assets/3d-vh-m-blood-vasculature.glb" xsd:anyURI property_value: skos:prefLabel "colic artery" xsd:string [Term] id: UBERON:0035549 name: vasculature of integument def: "The part of the circulatory system that lies within the subcutaneous tissue layers close to the surface of the skin." [http://orcid.org/0000-0002-6601-2165] subset: human_reference_atlas synonym: "dermis vasculature" NARROW [] synonym: "hypodermis vasculature" NARROW [] synonym: "skin vasculature" RELATED [] synonym: "subcutaneous vasculature" RELATED [] synonym: "superficial part of circulatory system" EXACT [] synonym: "superficial vasculature" EXACT [] synonym: "vasculature of skin" RELATED [FMA:225275] xref: FMA:225275 is_a: UBERON:0002049 ! vasculature intersection_of: UBERON:0002049 ! vasculature intersection_of: RO:0001025 UBERON:0002199 ! located in integument relationship: RO:0001025 UBERON:0002199 ! located in integument relationship: RO:0002216 GO:0001659 ! capable of part of temperature homeostasis property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "vasculature of integument" xsd:string [Term] id: UBERON:0035550 name: superficial vein def: "Any of the veins carrying deoxygenated blood from the subcutaneous tissue layers." [ncithesaurus:Superficial_Vein] synonym: "superfical vein" RELATED [Wikipedia:Superficial_vein] synonym: "superficial veins" RELATED [Wikipedia:Superficial_vein] synonym: "superficial vessels" RELATED [Wikipedia:Superficial_vein] xref: FMA:76719 xref: NCIT:C33666 xref: SCTID:341382008 xref: UMLS:C0226513 xref: Wikipedia:Superficial_vein is_a: UBERON:0001638 ! vein intersection_of: UBERON:0001638 ! vein intersection_of: BFO:0000050 UBERON:0035549 ! part of vasculature of integument relationship: BFO:0000050 UBERON:0035549 ! part of vasculature of integument property_value: skos:prefLabel "superficial vein" xsd:string [Term] id: UBERON:0035551 name: deep vasculature def: "The part of the circulatory system that lies deep beneath the subcutaneous tissue layers away from the surface of the skin." [http://orcid.org/0000-0002-6601-2165] synonym: "deep part of circulatory system" EXACT [] is_a: UBERON:0002049 ! vasculature intersection_of: UBERON:0002049 ! vasculature intersection_of: BSPO:0000107 UBERON:0002199 ! integument relationship: BSPO:0000107 UBERON:0002199 ! integument property_value: skos:prefLabel "deep vasculature" xsd:string [Term] id: UBERON:0035552 name: deep vein def: "A blood vessel carrying deoxygenated blood far beneath the skin usually accompanying an artery." [ncithesaurus:Deep_Vein] synonym: "deep veins" RELATED [Wikipedia:Deep_vein] synonym: "deep vessels" RELATED [Wikipedia:Deep_vein] xref: FMA:76718 xref: NCIT:C32444 xref: SCTID:341484008 xref: UMLS:C0226514 xref: Wikipedia:Deep_vein is_a: UBERON:0001638 ! vein intersection_of: UBERON:0001638 ! vein intersection_of: BFO:0000050 UBERON:0035551 ! part of deep vasculature relationship: BFO:0000050 UBERON:0035551 ! part of deep vasculature property_value: skos:prefLabel "deep vein" xsd:string [Term] id: UBERON:0035553 name: left cardiac chamber def: "Any chamber of the left side of the heart." [http://orcid.org/0000-0002-6601-2165] xref: FMA:7166 xref: SCTID:362008007 is_a: UBERON:0004151 ! cardiac chamber is_a: UBERON:0015212 ! lateral structure intersection_of: UBERON:0004151 ! cardiac chamber intersection_of: BSPO:0000120 UBERON:0000948 ! heart relationship: BSPO:0000120 UBERON:0000948 ! heart property_value: skos:prefLabel "left cardiac chamber" xsd:string [Term] id: UBERON:0035554 name: right cardiac chamber def: "Any chamber of the right side of the heart." [http://orcid.org/0000-0002-6601-2165] xref: FMA:7165 xref: SCTID:362007002 is_a: UBERON:0004151 ! cardiac chamber is_a: UBERON:0015212 ! lateral structure intersection_of: UBERON:0004151 ! cardiac chamber intersection_of: BSPO:0000121 UBERON:0000948 ! heart relationship: BSPO:0000121 UBERON:0000948 ! heart property_value: skos:prefLabel "right cardiac chamber" xsd:string [Term] id: UBERON:0035555 name: lateral line sense organ is_a: UBERON:0010521 ! electroreceptor organ intersection_of: UBERON:0000062 ! organ intersection_of: BFO:0000050 UBERON:0002540 ! part of lateral line system intersection_of: RO:0002215 GO:0050964 ! capable of detection of electrical stimulus involved in electroception relationship: BFO:0000050 UBERON:0002540 ! part of lateral line system relationship: RO:0002005 UBERON:0008906 ! innervated by lateral line nerve property_value: IAO:0000116 "ensure pit organ classifies here" xsd:string [Term] id: UBERON:0035597 name: profundal placode def: "An embryonic structure positioned halfway between the prospective eye and ear, adjacent to the future midbrain-hindbrain boundary. The profundal and the trigeminal ganglia are separate distally but fused at their proximal end as they condense around NF stage 24." [https://github.com/obophenotype/uberon/issues/693, PMID:21452441, XAO:0004093] synonym: "ophthalmic lobe of trigeminal placode" EXACT [NCBIBook:NBK53171] synonym: "ophthalmic lobe of trigeminal placode complex" EXACT [NCBIBook:NBK53171] synonym: "ophthalmic placode" EXACT [PMID:22512454] synonym: "profundus placode" EXACT [XAO:0004093] xref: XAO:0004093 is_a: UBERON:0009955 ! neurogenic placode relationship: BFO:0000050 UBERON:0003070 ! part of trigeminal placode complex [Term] id: UBERON:0035606 name: cartilage of external acoustic meatus synonym: "cartilage of acoustic meatus" EXACT [FMA:61298] synonym: "cartilage of auditory canal" EXACT [FMA:61298] synonym: "cartilago meatus acustici" EXACT [FMA:TA] synonym: "external acoustic meatus cartilage" EXACT [FMA:61298] xref: FMA:61298 is_a: UBERON:0034944 ! zone of organ intersection_of: UBERON:0034944 ! zone of organ intersection_of: BFO:0000050 UBERON:0001352 ! part of external acoustic meatus intersection_of: BFO:0000050 UBERON:0001867 ! part of cartilage of external ear relationship: BFO:0000050 UBERON:0001352 ! part of external acoustic meatus relationship: BFO:0000050 UBERON:0001867 ! part of cartilage of external ear [Term] id: UBERON:0035608 name: dura mater lymph vessel def: "Any lymph vessel that is located in the dura mater of the brain." [DOI:10.1038/nature14432, DOI:10.1111/joa.12381] comment: Louveau et al (DOI:10.1038/nature14432) claim the discovery of lymphatics in the cerebral dura mater, but this is disputed by Bucchieri et al (DOI:10.1111/joa.12381) synonym: "dural lymph vasculature" RELATED [] synonym: "dural lymph vessel" EXACT [] is_a: UBERON:0001473 ! lymphatic vessel intersection_of: UBERON:0001473 ! lymphatic vessel intersection_of: RO:0001025 UBERON:0002363 ! located in dura mater relationship: BFO:0000050 UBERON:0010743 ! part of meningeal cluster relationship: RO:0001025 UBERON:0002363 ! located in dura mater [Term] id: UBERON:0035610 name: hair canal def: "Tubular connection between the epidermal surface and the most distal part of the inner root sheath. Contains the hair shaft." [DOI:10.1016/j.cub.2008.12.005] is_a: UBERON:0004111 ! anatomical conduit intersection_of: UBERON:0004111 ! anatomical conduit intersection_of: RO:0002176 UBERON:0001003 ! connects skin epidermis intersection_of: RO:0002176 UBERON:0005941 ! connects hair inner root sheath intersection_of: RO:0002570 UBERON:0002074 ! conduit for hair shaft relationship: BFO:0000050 UBERON:0000014 ! part of zone of skin relationship: RO:0002176 UBERON:0001003 ! connects skin epidermis relationship: RO:0002176 UBERON:0005941 ! connects hair inner root sheath relationship: RO:0002570 UBERON:0002074 ! conduit for hair shaft [Term] id: UBERON:0035639 name: ocular adnexa def: "The parts of the orbital region that are outside of the the eyeball, including the lacrimal apparatus, the extraocular muscles and the eyelids, eyelashes, eyebrows and the conjunctiva." [HPO:pr, http://medical-dictionary.thefreedictionary.com/ocular+adnexa, https://github.com/obophenotype/uberon/issues/1132, UBERON:cjm] synonym: "accessory parts of orbital region" RELATED [] synonym: "accessory visual structures" RELATED [FMA:76554, Wikipedia:Accessory_visual_structures] synonym: "accessory visual structures set" RELATED [FMA:76554] synonym: "adnexa oculi" EXACT OMO:0003011 [http://medical-dictionary.thefreedictionary.com/ocular+adnexa] synonym: "adnexal parts of orbital region" RELATED [] synonym: "appendage of eye" RELATED [http://medical-dictionary.thefreedictionary.com/ocular+adnexa] synonym: "appendages of the eye" RELATED OMO:0003004 [http://medical-dictionary.thefreedictionary.com/ocular+adnexa] synonym: "eye adnexa" RELATED [] synonym: "set of accessory visual structures" RELATED [FMA:76554] synonym: "structurae oculi accessoriae" RELATED OMO:0003011 [Wikipedia:Accessory_visual_structures] xref: FMA:76554 xref: NCIT:C32574 xref: SCTID:120612006 xref: UMLS:C0229243 xref: Wikipedia:Accessory_visual_structures is_a: UBERON:0034921 ! multi organ part structure relationship: BFO:0000050 UBERON:0004088 ! part of orbital region property_value: skos:prefLabel "ocular adnexa" xsd:string [Term] id: UBERON:0035642 name: laryngeal nerve def: "Any nerve that innervates the larynx." [UBERON:cjm] xref: MESH:D007823 xref: SCTID:307013006 is_a: UBERON:0001021 ! nerve intersection_of: UBERON:0001021 ! nerve intersection_of: RO:0002134 UBERON:0001737 ! innervates larynx relationship: RO:0002134 UBERON:0001737 ! innervates larynx property_value: skos:prefLabel "laryngeal nerve" xsd:string [Term] id: UBERON:0035648 name: nerve innervating pinna def: "Any nerve that innervates the pinna." [UBERON:cjm] synonym: "auricular nerve" EXACT [MA:0001232] xref: EMAPA:36513 xref: MA:0001232 is_a: UBERON:0011779 ! nerve of head region intersection_of: UBERON:0001021 ! nerve intersection_of: RO:0002134 UBERON:0001757 ! innervates pinna relationship: RO:0002134 UBERON:0001757 ! innervates pinna relationship: RO:0002380 UBERON:0001647 {source="FMA"} ! branching part of facial nerve [Term] id: UBERON:0035649 name: nerve of penis def: "Any nerve that innervates the penis." [UBERON:cjm] synonym: "penile nerve" EXACT [] synonym: "penis nerve" EXACT [] xref: EMAPA:35057 is_a: UBERON:0001021 ! nerve intersection_of: UBERON:0001021 ! nerve intersection_of: RO:0002134 UBERON:0000989 ! innervates penis relationship: RO:0002134 UBERON:0000989 ! innervates penis [Term] id: UBERON:0035650 name: nerve of clitoris def: "Any nerve that innervates the clitoris." [UBERON:cjm] subset: human_reference_atlas synonym: "clitoral nerve" EXACT [] synonym: "clitoris nerve" EXACT [] xref: EMAPA:35044 is_a: UBERON:0001021 ! nerve intersection_of: UBERON:0001021 ! nerve intersection_of: RO:0002134 UBERON:0002411 ! innervates clitoris relationship: RO:0002134 UBERON:0002411 ! innervates clitoris property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0035651 name: glans xref: Wikipedia:Glans is_a: BFO:0000002 is_a: UBERON:0000063 ! organ subunit is_a: UBERON:0005156 ! reproductive structure union_of: UBERON:0001299 ! glans penis union_of: UBERON:0006653 ! glans clitoris relationship: BFO:0000050 UBERON:0003133 ! part of reproductive organ relationship: RO:0002202 UBERON:0013238 ! develops from future glans [Term] id: UBERON:0035662 name: parotid vein subset: human_reference_atlas synonym: "anterior parotid vein" EXACT [FMA:50919] synonym: "parotid branch of facial vein" EXACT [FMA:50919] xref: FMA:50919 is_a: UBERON:0001638 ! vein intersection_of: UBERON:0001638 ! vein intersection_of: RO:0020102 UBERON:0001831 ! vessel drains blood from parotid gland relationship: RO:0002376 UBERON:0001653 ! tributary of facial vein relationship: RO:0020102 UBERON:0001831 ! vessel drains blood from parotid gland property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0035763 name: cavity of cardiac chamber synonym: "cardiac chamber cavity" EXACT [FMA:9464] synonym: "heart cavity" EXACT [FMA:9464] synonym: "heart lumen" EXACT [EHDAA2:0004181] xref: EHDAA2:0004181 xref: FMA:9464 is_a: UBERON:0002553 ! anatomical cavity intersection_of: UBERON:0002553 ! anatomical cavity intersection_of: RO:0002572 UBERON:0004151 ! luminal space of cardiac chamber relationship: RO:0002219 UBERON:0002165 {source="FMA"} ! surrounded by endocardium relationship: RO:0002572 UBERON:0004151 ! luminal space of cardiac chamber property_value: skos:prefLabel "cavity of cardiac chamber" xsd:string [Term] id: UBERON:0035764 name: pulmonary lymph node synonym: "intrapulmonary lymph node" EXACT [FMA:5968] synonym: "pulmonary node" EXACT [FMA:5968] xref: FMA:5968 is_a: UBERON:0000029 ! lymph node intersection_of: UBERON:0000029 ! lymph node intersection_of: BFO:0000050 UBERON:0008886 ! part of pulmonary vascular system relationship: BFO:0000050 UBERON:0008886 ! part of pulmonary vascular system [Term] id: UBERON:0035767 name: intrapulmonary bronchus xref: FMA:223208 xref: NCIT:C12930 xref: UMLS:C1512970 is_a: UBERON:0002185 ! bronchus intersection_of: UBERON:0002185 ! bronchus intersection_of: BFO:0000050 UBERON:0002048 ! part of lung relationship: BFO:0000050 UBERON:0002048 ! part of lung property_value: skos:prefLabel "intrapulmonary bronchus" xsd:string [Term] id: UBERON:0035769 name: mesenteric ganglion xref: SCTID:314754005 is_a: UBERON:0003964 ! prevertebral ganglion intersection_of: UBERON:0003964 ! prevertebral ganglion intersection_of: BFO:0000050 UBERON:0035771 ! part of mesenteric plexus relationship: BFO:0000050 UBERON:0035771 ! part of mesenteric plexus [Term] id: UBERON:0035770 name: inferior mesenteric nerve plexus def: "The inferior mesenteric plexus is derived chiefly from the aortic plexus. It surrounds the inferior mesenteric artery, and divides into a number of secondary plexuses, which are distributed to all the parts supplied by the artery, viz. , the left colic and sigmoid plexuses, which supply the descending and sigmoid parts of the colon; and the superior hemorrhoidal plexus, which supplies the rectum and joins in the pelvis with branches from the pelvic plexuses." [Wikipedia:Inferior_mesenteric_plexus] subset: human_reference_atlas synonym: "inferior mesenteric plexus" EXACT [FMA:6641] synonym: "plexus mesentericus inferior" EXACT OMO:0003011 [FMA:TA] synonym: "plexus nervosus mesentericus inferior" EXACT OMO:0003011 [FMA:TA] xref: FMA:6641 xref: SCTID:362495005 xref: Wikipedia:Inferior_mesenteric_plexus is_a: UBERON:0000122 ! neuron projection bundle is_a: UBERON:0035771 ! mesenteric plexus intersection_of: UBERON:0035771 ! mesenteric plexus intersection_of: extends_fibers_into UBERON:0035772 ! aortic plexus intersection_of: RO:0002134 UBERON:0001052 ! innervates rectum intersection_of: RO:0002134 UBERON:0001158 ! innervates descending colon intersection_of: RO:0002134 UBERON:0001159 ! innervates sigmoid colon relationship: extends_fibers_into UBERON:0035772 ! aortic plexus relationship: RO:0002134 UBERON:0001052 ! innervates rectum relationship: RO:0002134 UBERON:0001158 ! innervates descending colon relationship: RO:0002134 UBERON:0001159 ! innervates sigmoid colon property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0035771 name: mesenteric plexus subset: human_reference_atlas xref: SCTID:314752009 is_a: UBERON:0001816 ! autonomic nerve plexus property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0035772 name: aortic plexus subset: human_reference_atlas xref: FMA:80133 is_a: UBERON:0001816 {source="FMA"} ! autonomic nerve plexus property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0035775 name: submandibular region def: "The region between the mandible and the hyoid bone that contains the submandibular and sublingual glands, suprahyoid muscles, submandibular ganglion, and lingual artery." [https://github.com/obophenotype/uberon/issues/1137] synonym: "digastric triangle" NARROW [FMA:57779, Wikipedia:Submandibular_triangle] synonym: "submandibular triangle" NARROW [FMA:57779] synonym: "submaxillary triangle" NARROW [FMA:57779, Wikipedia:Submandibular_triangle] synonym: "trigonum submandibulare" NARROW OMO:0003011 [FMA:TA] xref: FMA:57779 xref: Wikipedia:Submandibular_triangle is_a: UBERON:0000475 ! organism subdivision relationship: BFO:0000050 UBERON:0000974 ! part of neck property_value: foaf:depiction "https://upload.wikimedia.org/wikipedia/commons/thumb/3/36/Musculi_coli_base%2C_my_edits_for_tringles%2C_labeled_triangles%2C_Submandib.svg/500px-Musculi_coli_base%2C_my_edits_for_tringles%2C_labeled_triangles%2C_Submandib.svg.png" xsd:anyURI [Term] id: UBERON:0035776 name: accessory ciliary ganglion def: "A parasympathetic ganglion located on the short ciliary nerve differentiated from the main ciliary ganglion by virtue of the fact that it had no root derived directly from the inferior trunk of the oculomotor nerve and it never attaches to this nerve." [PMID:2802184] is_a: UBERON:0035783 ! ganglion of ciliary nerve relationship: BFO:0000050 UBERON:0035639 {source="http://orcid.org/0000-0001-9114-8737"} ! part of ocular adnexa [Term] id: UBERON:0035783 name: ganglion of ciliary nerve def: "Any parasympathetic ganglion that extends fibers into the short ciliary nerve. Includes both the main and acccessory ciliary ganglia." [UBERON:cjm] is_a: UBERON:0001808 ! parasympathetic ganglion intersection_of: UBERON:0001808 ! parasympathetic ganglion intersection_of: extends_fibers_into UBERON:0022302 ! short ciliary nerve union_of: UBERON:0002058 ! main ciliary ganglion union_of: UBERON:0035776 ! accessory ciliary ganglion relationship: BFO:0000050 UBERON:0004088 ! part of orbital region relationship: extends_fibers_into UBERON:0022302 ! short ciliary nerve [Term] id: UBERON:0035784 name: seminal clot def: "A portion of semen in a coagulated state." [http://orcid.org/0000-0002-6601-2165, PMID:18482984] synonym: "seminal coagulum" EXACT [PMID:18482984] is_a: UBERON:0001968 ! semen intersection_of: UBERON:0001968 ! semen intersection_of: RO:0002353 GO:0050817 ! output of coagulation relationship: RO:0002353 GO:0050817 ! output of coagulation [Term] id: UBERON:0035788 name: layer of CA3 field subset: non_informative xref: FMA:277848 is_a: UBERON:0002305 ! layer of hippocampus intersection_of: UBERON:0002305 ! layer of hippocampus intersection_of: BFO:0000050 UBERON:0003883 ! part of CA3 field of hippocampus relationship: BFO:0000050 UBERON:0003883 ! part of CA3 field of hippocampus property_value: skos:prefLabel "layer of CA3 field" xsd:string [Term] id: UBERON:0035803 name: extrapyramidal tract system def: "A neural network located in the brain that is part of the motor system involved in the coordination of movement that is distinct from the pyramidal tract." [Wikipedia:Extrapyramidal_system] synonym: "eps" RELATED OMO:0003000 [MBA:1000] synonym: "extra-pyramidal tract" RELATED [Wikipedia:Extrapyramidal_system] synonym: "extrapyramidal fibre" RELATED [Wikipedia:Extrapyramidal_system] synonym: "extrapyramidal motor system" RELATED [Wikipedia:Extrapyramidal_system] synonym: "extrapyramidal pathway" RELATED [NeuroNames:2070] synonym: "extrapyramidal system" RELATED [NeuroNames:2070] synonym: "extrapyramidal tracts" RELATED [Wikipedia:Extrapyramidal_system] synonym: "extrapyramindal system" RELATED [Wikipedia:Extrapyramidal_system] xref: MBA:1000 xref: MESH:D005116 xref: neuronames:2070 xref: neuronames:3015 xref: SCTID:362288003 xref: SCTID:362400005 xref: Wikipedia:Extrapyramidal_system is_a: UBERON:0002616 {source="MBA"} ! regional part of brain relationship: BFO:0000050 UBERON:0025525 ! part of motor system property_value: skos:prefLabel "extrapyramidal tract system" xsd:string [Term] id: UBERON:0035804 name: future mouth def: "The primordial mouth region of the developing head." [MP:0003119] synonym: "primitive mouth" EXACT [FMA:293105] synonym: "primordial mouth" EXACT [] xref: FMA:293105 is_a: BFO:0000002 is_a: UBERON:0013522 ! subdivision of tube relationship: BFO:0000050 UBERON:0007026 ! part of presumptive gut relationship: BFO:0000051 UBERON:0000925 ! has part endoderm relationship: BFO:0000051 UBERON:0000930 ! has part stomodeum property_value: skos:prefLabel "future mouth" xsd:string [Term] id: UBERON:0035805 name: muscle layer of sigmoid colon def: "A muscle layer that is part of the sigmoid colon." [https://github.com/obophenotype/uberon/issues/1162] synonym: "muscularis externa of sigmoid colon" EXACT [FMA:15028] synonym: "muscularis propria of sigmoid colon" EXACT [] synonym: "sigmoid colon muscularis propria" EXACT [] synonym: "sigmoideum muscularis" RELATED [] synonym: "tunica muscularis colon sigmoideum" RELATED [] xref: FMA:15028 is_a: UBERON:0012489 ! muscle layer of colon intersection_of: UBERON:0006660 ! muscular coat intersection_of: BFO:0000050 UBERON:0001159 ! part of sigmoid colon relationship: BFO:0000050 UBERON:0001159 ! part of sigmoid colon property_value: skos:prefLabel "muscle layer of sigmoid colon" xsd:string [Term] id: UBERON:0035809 name: serous cavity xref: FMA:12241 xref: SCTID:304404008 is_a: UBERON:0002553 ! anatomical cavity intersection_of: UBERON:0002553 ! anatomical cavity intersection_of: RO:0002572 UBERON:0005906 ! luminal space of serous sac relationship: RO:0002572 UBERON:0005906 ! luminal space of serous sac property_value: skos:prefLabel "serous cavity" xsd:string [Term] id: UBERON:0035814 name: pericardial fat def: "The sum of epicardial and paracardial fat deposits." [DOI:10.5935/abc.20130138] xref: SCTID:42267001 xref: ZFA:0005765 is_a: UBERON:0035818 ! visceral fat intersection_of: UBERON:0001013 ! adipose tissue intersection_of: RO:0002221 UBERON:0000948 ! surrounds heart relationship: RO:0002221 UBERON:0000948 ! surrounds heart property_value: skos:prefLabel "pericardial fat" xsd:string [Term] id: UBERON:0035815 name: paracardial fat def: "Fat deposits in the mediastinum outside the parietal pericardium ." [DOI:10.5935/abc.20130138] synonym: "intrathoracic fat" EXACT [DOI:10.5935/abc.20130138] is_a: UBERON:0035814 ! pericardial fat intersection_of: UBERON:0001013 ! adipose tissue intersection_of: RO:0002220 UBERON:0002408 ! adjacent to parietal serous pericardium intersection_of: RO:0002221 UBERON:0000948 ! surrounds heart relationship: RO:0002220 UBERON:0002408 ! adjacent to parietal serous pericardium property_value: skos:prefLabel "paracardial fat" xsd:string [Term] id: UBERON:0035818 name: visceral fat def: "Any fat deposit surrounding a visceral organ." [UBERON:cjm] is_a: UBERON:0001013 ! adipose tissue intersection_of: UBERON:0001013 ! adipose tissue intersection_of: RO:0002221 UBERON:0000062 ! surrounds organ relationship: RO:0002221 UBERON:0000062 ! surrounds organ property_value: skos:prefLabel "visceral fat" xsd:string [Term] id: UBERON:0035819 name: abdominopelvic cavity def: "The part of the ventral body cavity that is within the abdominal segment of the trunk, which encompasses the abdomen proper plus pelvic cavity." [UBERON:cjm] synonym: "cavitas abdominis et pelvis" EXACT OMO:0003011 [FMA:TA] xref: FMA:12267 xref: Wikipedia:Abdominopelvic_cavity is_a: UBERON:0000464 ! anatomical space intersection_of: UBERON:0000464 ! anatomical space intersection_of: BFO:0000050 UBERON:0002323 ! part of coelemic cavity lumen intersection_of: RO:0002572 UBERON:0002417 ! luminal space of abdominal segment of trunk relationship: BFO:0000050 UBERON:0002323 ! part of coelemic cavity lumen relationship: RO:0002572 UBERON:0002417 ! luminal space of abdominal segment of trunk property_value: skos:prefLabel "abdominopelvic cavity" xsd:string [Term] id: UBERON:0035820 name: peritoneal sac def: "A serous sac that is the aggregate of the peritoneum and the peritoneal cavity, located in the abdominal cavity." [https://github.com/obophenotype/uberon/issues/86] synonym: "peritoneal component" RELATED [EMAPA:16137] xref: EMAPA:16137 xref: FMA:9908 is_a: UBERON:0002075 ! viscus is_a: UBERON:0005906 ! serous sac relationship: BFO:0000051 UBERON:0001179 ! has part peritoneal cavity relationship: BFO:0000051 UBERON:0002358 ! has part peritoneum relationship: RO:0001025 UBERON:0003684 ! located in abdominal cavity property_value: skos:prefLabel "peritoneal sac" xsd:string [Term] id: UBERON:0035825 name: left adrenal gland cortex def: "The thick outer layer of the adrenal gland that is in the left side of the abdomen." [https://github.com/obophenotype/uberon/issues/1170] synonym: "cortex of left adrenal gland" EXACT [FMA:69089] synonym: "cortex of left suprarenal gland" EXACT [FMA:69089] synonym: "left adrenal cortex" EXACT [FMA:69089] xref: FMA:69089 is_a: UBERON:0001235 {is_inferred="true"} ! adrenal cortex intersection_of: UBERON:0001851 ! cortex intersection_of: BFO:0000050 UBERON:0001234 ! part of left adrenal gland relationship: BFO:0000050 UBERON:0001234 ! part of left adrenal gland [Term] id: UBERON:0035826 name: left adrenal gland medulla def: "The adrenal gland medulla that is in the left side of the abdomen." [https://github.com/obophenotype/uberon/issues/1170] synonym: "left adrenal medulla" EXACT [FMA:69092] synonym: "medulla of left adrenal gland" EXACT [FMA:69092] synonym: "medulla of left suprarenal gland" EXACT [FMA:69092] xref: FMA:69092 is_a: UBERON:0001236 {is_inferred="true"} ! adrenal medulla intersection_of: UBERON:0000958 ! medulla of organ intersection_of: BFO:0000050 UBERON:0001234 ! part of left adrenal gland relationship: BFO:0000050 UBERON:0001234 ! part of left adrenal gland [Term] id: UBERON:0035827 name: right adrenal gland cortex def: "The thick outer layer of the adrenal gland that is in the right side of the abdomen." [https://github.com/obophenotype/uberon/issues/1170] synonym: "cortex of right adrenal gland" EXACT [FMA:69088] synonym: "cortex of right suprarenal gland" EXACT [FMA:69088] synonym: "right adrenal cortex" EXACT [FMA:69088] xref: FMA:69088 is_a: UBERON:0001235 {is_inferred="true"} ! adrenal cortex intersection_of: UBERON:0001851 ! cortex intersection_of: BFO:0000050 UBERON:0001233 ! part of right adrenal gland relationship: BFO:0000050 UBERON:0001233 ! part of right adrenal gland [Term] id: UBERON:0035828 name: right adrenal gland medulla def: "The adrenal gland medulla that is in the right side of the abdomen." [https://github.com/obophenotype/uberon/issues/1170] synonym: "medulla of right adrenal gland" EXACT [FMA:69091] synonym: "medulla of right suprarenal gland" EXACT [FMA:69091] synonym: "right adrenal medulla" EXACT [FMA:69091] xref: FMA:69091 is_a: UBERON:0001236 {is_inferred="true"} ! adrenal medulla intersection_of: UBERON:0000958 ! medulla of organ intersection_of: BFO:0000050 UBERON:0001233 ! part of right adrenal gland relationship: BFO:0000050 UBERON:0001233 ! part of right adrenal gland [Term] id: UBERON:0035927 name: sulcus of parietal lobe synonym: "parietal lobe sulci" EXACT OMO:0003004 [HBA:9370] synonym: "parietal lobe sulcus" EXACT [] synonym: "PLs" RELATED OMO:0003000 [HBA:9370] xref: HBA:9370 xref: SCTID:314145001 is_a: UBERON:0013118 ! sulcus of brain intersection_of: UBERON:0013118 ! sulcus of brain intersection_of: BFO:0000050 UBERON:0001872 ! part of parietal lobe relationship: BFO:0000050 UBERON:0001872 ! part of parietal lobe property_value: skos:prefLabel "sulcus of parietal lobe" xsd:string [Term] id: UBERON:0035956 name: epididymal lumen def: "The lumen of the epididymis." [GOC:DOS, https://github.com/obophenotype/uberon/issues/1209] synonym: "epididymis lumen" EXACT [FMA:18274] synonym: "lumen of epididymis" EXACT [FMA:18274] xref: FMA:18274 xref: SCTID:367722009 is_a: UBERON:0000464 ! anatomical space intersection_of: UBERON:0000464 ! anatomical space intersection_of: RO:0002572 UBERON:0001301 ! luminal space of epididymis relationship: RO:0001015 UBERON:0006530 {source="FMA"} ! location of seminal fluid relationship: RO:0002572 UBERON:0001301 ! luminal space of epididymis [Term] id: UBERON:0035965 name: wall of blood vessel synonym: "blood vessel wall" EXACT [FMA:67473] synonym: "vascular wall" RELATED [BTO:0004378] xref: BTO:0004378 xref: EMAPA:37987 {source="MA:th"} xref: FMA:67473 is_a: UBERON:0000060 ! anatomical wall intersection_of: UBERON:0000060 ! anatomical wall intersection_of: BFO:0000050 UBERON:0001981 ! part of blood vessel relationship: BFO:0000050 UBERON:0001981 ! part of blood vessel relationship: RO:0002473 UBERON:0004797 ! composed primarily of blood vessel layer property_value: skos:prefLabel "wall of blood vessel" xsd:string [Term] id: UBERON:0035999 name: dopaminergic cell groups def: "Collections of neurons in the central nervous system that have been demonstrated by histochemical fluorescence to contain the neurotransmitter dopamine ( Fuxe-1970 )." [NeuroNames:3138] synonym: "DA cell groups" RELATED [NeuroNames:3138] synonym: "dopaminergic cell groups" RELATED [NeuroNames:3138] synonym: "dopaminergic nuclei" RELATED [NeuroNames:3138] xref: neuronames:3138 is_a: UBERON:0002616 ! regional part of brain relationship: RO:0002473 CL:0000700 ! composed primarily of dopaminergic neuron property_value: skos:prefLabel "dopaminergic cell groups" xsd:string [Term] id: UBERON:0036007 name: A13 dopaminergic cell group def: "A group of cells that fluoresce for dopamine and are distributed in clusters that, in the primate, are ventral and medial to the mammillothalamic tract of the hypothalamus; a few extend into the reuniens nucleus of the thalamus (Felten-1983). In the mouse A13 is located ventral to the mammillothalamic tract of the thalamus in the zona incerta (adapted from Brain Info)." [NLX:91101] synonym: "A13" RELATED OMO:0003000 [MBA:796] synonym: "A13 cell group" RELATED [NeuroNames:1851] synonym: "A13 dopamine cells" RELATED [NeuroNames:1851] synonym: "dopaminergic group A13" RELATED [NeuroNames:1851] synonym: "zona incerta, dopaminergic group" RELATED [NeuroNames:1851] xref: MBA:796 xref: neuronames:1851 xref: NLX:91101 is_a: UBERON:0035999 ! dopaminergic cell groups relationship: BFO:0000050 UBERON:0001907 {source="MBA"} ! part of zona incerta property_value: skos:prefLabel "A13 dopaminergic cell group" xsd:string [Term] id: UBERON:0036072 name: respiratory primordium epithelium xref: EHDAA2:0004070 is_a: UBERON:0004185 ! endodermal part of digestive tract is_a: UBERON:0005911 ! endo-epithelium is_a: UBERON:0007499 ! epithelial sac is_a: UBERON:0009854 ! digestive tract diverticulum is_a: UBERON:0015833 ! foregut epithelium intersection_of: UBERON:0007499 ! epithelial sac intersection_of: BFO:0000050 UBERON:0008947 ! part of respiratory primordium relationship: BFO:0000050 UBERON:0008947 ! part of respiratory primordium relationship: RO:0002202 UBERON:0007690 {source="EHDAA2"} ! develops from early pharyngeal endoderm property_value: skos:prefLabel "respiratory primordium epithelium" xsd:string [Term] id: UBERON:0036073 name: respiratory primordium mesenchyme synonym: "respiratory primordium associated mesenchyme" EXACT [EHDAA2:0004071] xref: EHDAA2:0004071 is_a: BFO:0000002 is_a: UBERON:0003104 ! mesenchyme intersection_of: UBERON:0003104 ! mesenchyme intersection_of: BFO:0000050 UBERON:0008947 ! part of respiratory primordium relationship: BFO:0000050 UBERON:0008947 ! part of respiratory primordium relationship: RO:0002202 UBERON:0004873 {source="EHDAA2"} ! develops from splanchnopleure property_value: skos:prefLabel "respiratory primordium mesenchyme" xsd:string [Term] id: UBERON:0036146 name: cardiopharyngeal field def: "An region of the mesoderm that includes anterior lateral mesoderm of the first heart field plus contiguous pharyngeal mesoderm that gives rise to second-heart-field-derived regions of the heart and branchiomeric muscles." [http://www.nature.com/nature/journal/v520/n7548/full/nature14435.html#bx1, https://orcid.org/0000-0003-3308-6245] is_a: UBERON:0002050 ! embryonic structure is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0005291 ! embryonic tissue is_a: UBERON:0007688 ! anlage property_value: skos:prefLabel "cardiopharyngeal field" xsd:string [Term] id: UBERON:0036150 name: skin appendage follicle def: "An organ subunit in the skin that gives rise to cutaneous appendage." [https://github.com/obophenotype/uberon/issues/1266, UBERON:cjm] synonym: "cutaneous appendage follicle" EXACT [] synonym: "follicle" BROAD [] synonym: "skin follicle" EXACT [] is_a: UBERON:0000063 ! organ subunit intersection_of: UBERON:0000063 ! organ subunit intersection_of: BFO:0000050 UBERON:0000014 ! part of zone of skin intersection_of: RO:0002131 UBERON:0001003 ! overlaps skin epidermis intersection_of: RO:0002131 UBERON:0002067 ! overlaps dermis intersection_of: RO:0002387 UBERON:0000021 ! has potential to develop into cutaneous appendage relationship: BFO:0000050 UBERON:0000014 ! part of zone of skin relationship: RO:0002131 UBERON:0001003 ! overlaps skin epidermis relationship: RO:0002131 UBERON:0002067 ! overlaps dermis relationship: RO:0002387 UBERON:0000021 ! has potential to develop into cutaneous appendage [Term] id: UBERON:0036186 name: fibroelastic connective tissue xref: FMA:83520 is_a: UBERON:0002521 ! elastic tissue is_a: UBERON:0011824 ! fibrous connective tissue intersection_of: UBERON:0011824 ! fibrous connective tissue intersection_of: RO:0002473 GO:0071953 ! composed primarily of elastic fiber property_value: skos:prefLabel "fibroelastic connective tissue" xsd:string [Term] id: UBERON:0036214 name: rectosigmoid junction def: "An anatomical junction that is between the sigmoid colon and rectum." [https://github.com/obophenotype/uberon/issues/1319, https://www.cdc.gov/cancer/npcr/pdf/abstracting/colon.pdf, NCIT:C54188] synonym: "rectosigmoid region" RELATED [NCIT:C54188] xref: NCIT:C54188 xref: SCTID:245429006 is_a: UBERON:8410024 ! intestinal junction intersection_of: UBERON:0007651 ! anatomical junction intersection_of: RO:0002176 UBERON:0001052 ! connects rectum intersection_of: RO:0002176 UBERON:0001159 ! connects sigmoid colon relationship: RO:0002176 UBERON:0001052 ! connects rectum relationship: RO:0002176 UBERON:0001159 ! connects sigmoid colon property_value: skos:prefLabel "rectosigmoid junction" xsd:string [Term] id: UBERON:0036215 name: anatomical surface region def: "Material anatomical entity that forms the outermost boundary of an anatomical structure." [https://github.com/obophenotype/uberon/issues/1324] subset: common_anatomy xref: AAO:0010270 xref: ZFA:0005594 is_a: BFO:0000004 is_a: UBERON:0000465 ! material anatomical entity relationship: RO:0002007 UBERON:0000061 ! bounding layer of anatomical structure property_value: RO:0002175 NCBITaxon:33090 property_value: RO:0002175 NCBITaxon:33208 property_value: RO:0002175 NCBITaxon:4751 property_value: skos:prefLabel "anatomical surface region" xsd:string [Term] id: UBERON:0036217 name: coelomic fluid def: "A bodily fluid that is located in the coelom." [https://github.com/obophenotype/uberon/issues/1326, PMID:10874572] xref: BTO:0001708 is_a: UBERON:0006314 ! bodily fluid intersection_of: UBERON:0006314 ! bodily fluid intersection_of: RO:0001025 UBERON:0011997 ! located in coelom relationship: RO:0001025 UBERON:0011997 ! located in coelom property_value: skos:prefLabel "coelomic fluid" xsd:string [Term] id: UBERON:0036224 name: corticobulbar and corticospinal tracts def: "The corticobulbar and corticospinal tracts combined." [https://github.com/obophenotype/uberon/issues/553] synonym: "pyramidal tract" BROAD INCONSISTENT [BIRNLEX:1464, MP:0002878, neuronames:1320] xref: Wikipedia:Pyramidal_tracts is_a: UBERON:0001018 ! axon tract relationship: BFO:0000050 UBERON:0002316 {source="NIFSTD"} ! part of white matter property_value: skos:prefLabel "corticobulbar and corticospinal tracts" xsd:string [Term] id: UBERON:0036225 name: respiratory system gland def: "Any gland that is part os the respiratory system." [UBERON:cjm] is_a: UBERON:0002530 ! gland intersection_of: UBERON:0002530 ! gland intersection_of: BFO:0000050 UBERON:0001004 ! part of respiratory system relationship: BFO:0000050 UBERON:0001004 ! part of respiratory system property_value: skos:prefLabel "respiratory system gland" xsd:string [Term] id: UBERON:0036242 name: post-embryonic notochord def: "A notochord that has persisted beyond the embryonic stage." [UBERON:cjm] is_a: UBERON:0002328 ! notochord intersection_of: UBERON:0002328 ! notochord intersection_of: BFO:0000050 UBERON:0009953 ! part of post-embryonic organism relationship: BFO:0000050 UBERON:0009953 ! part of post-embryonic organism property_value: RO:0002161 NCBITaxon:32524 property_value: RO:0002175 NCBITaxon:118072 property_value: RO:0002175 NCBITaxon:7737 property_value: RO:0002175 NCBITaxon:7746 property_value: RO:0002175 NCBITaxon:7878 property_value: RO:0002175 NCBITaxon:8292 property_value: skos:prefLabel "post-embryonic notochord" xsd:string [Term] id: UBERON:0036243 name: vaginal fluid def: "Fluid that lines the vaginal walls that consists of multiple secretions that collect in the vagina from different glands." [http://www.bumc.bu.edu/sexualmedicine/physicianinformation/female-genital-anatomy/] synonym: "vaginal discharge" RELATED [] synonym: "vaginal secretion" RELATED [] is_a: UBERON:0006314 ! bodily fluid intersection_of: UBERON:0006314 ! bodily fluid intersection_of: RO:0001025 UBERON:0000996 ! located in vagina relationship: RO:0001025 UBERON:0000996 ! located in vagina [Term] id: UBERON:0036244 name: secretion of serous membrane def: "A transudate found in the serous sac." [FMA:20932] synonym: "serous fluid" BROAD [FMA:20932] synonym: "serous sac fluid" EXACT [] xref: FMA:20932 is_a: UBERON:0007779 ! transudate intersection_of: UBERON:0007779 ! transudate intersection_of: filtered_through UBERON:0000042 ! serous membrane relationship: filtered_through UBERON:0000042 ! serous membrane relationship: RO:0001025 UBERON:0005906 ! located in serous sac property_value: skos:prefLabel "secretion of serous membrane" xsd:string [Term] id: UBERON:0036245 name: parenchyma of mammary gland def: "Parenchymal tissue that consists of the alveoli, grape-like clusters where milk is stored, and branching ducts, which are tubular canals carrying gladular secretions." [http://www.newworldencyclopedia.org/entry/Mammary_gland, https://github.com/obophenotype/uberon/issues/1349, https://orcid.org/0000-0003-3308-6245] synonym: "lactiferous gland parenchyma" EXACT [] synonym: "mammary gland parenchyma" EXACT [] synonym: "parenchyma of lactiferous gland" EXACT [] is_a: UBERON:0000353 ! parenchyma intersection_of: UBERON:0000353 ! parenchyma intersection_of: BFO:0000050 UBERON:0001911 ! part of mammary gland relationship: BFO:0000050 UBERON:0001911 ! part of mammary gland [Term] id: UBERON:0036248 name: joint of auditory ossicle def: "Any synovial joint that connects auditory ossicles." [UBERON:cjm] synonym: "auditory ossicle joint" EXACT [] synonym: "auditory ossicles joint" EXACT [FMA:60063] synonym: "joint of auditory ossicles" EXACT [FMA:60063] xref: FMA:60063 is_a: UBERON:0002217 ! synovial joint intersection_of: UBERON:0002217 ! synovial joint intersection_of: RO:0002176 UBERON:0035130 ! connects auditory ossicle endochondral element relationship: BFO:0000050 UBERON:0000033 ! part of head relationship: RO:0002176 UBERON:0035130 ! connects auditory ossicle endochondral element [Term] id: UBERON:0036253 name: orifice of skull synonym: "cranial orifice" EXACT [FMA:53133] synonym: "skull orifice" EXACT [FMA:53133] xref: FMA:53133 is_a: UBERON:0000161 ! orifice intersection_of: UBERON:0000161 ! orifice intersection_of: BFO:0000050 UBERON:0003129 ! part of skull relationship: BFO:0000050 UBERON:0003129 ! part of skull property_value: skos:prefLabel "orifice of skull" xsd:string [Term] id: UBERON:0036262 name: uterine ligament def: "Any of the eight ligaments pertaining to the uterus including the anterior, posterior, lateral, sacro-uterine and round ligaments." [NCIT:C61360] xref: NCIT:C61360 xref: SCTID:272668006 is_a: UBERON:0000211 ! ligament is_a: UBERON:0005156 ! reproductive structure intersection_of: UBERON:0000211 ! ligament intersection_of: BFO:0000050 UBERON:0000002 ! part of uterine cervix relationship: BFO:0000050 UBERON:0000002 ! part of uterine cervix [Term] id: UBERON:0036264 name: zygomaticotemporal nerve def: "The zygomaticotemporal nerve or zygomaticotemporal branch (temporal branch) is derived from the maxillary branch of the trigeminal nerve (Cranial nerve V). It runs along the lateral wall of the orbit in a groove in the zygomatic bone, receives a branch of communication from the lacrimal, and passes through zygomaticotemporal foramen in the zygomatic bone to enter the temporal fossa. It ascends between the bone, and substance of the Temporalis muscle, pierces the temporal fascia about 2.5 cm. above the zygomatic arch, and is distributed to the skin of the side of the forehead, and communicates with the facial nerve and with the auriculotemporal branch of the mandibular nerve. As it pierces the temporal fascia, it gives off a slender twig, which runs between the two layers of the fascia to the lateral angle of the orbit." [Wikipedia:Zygomaticotemporal_nerve] synonym: "ramus zygomaticotemporalis (Nervus zygomaticus)" EXACT [FMA:52972] synonym: "ramus zygomaticotemporalis nervus zygomatici" EXACT OMO:0003011 [FMA:TA] synonym: "zygomaticotemporal" RELATED [Wikipedia:Zygomaticotemporal_nerve] synonym: "zygomaticotemporal branch" RELATED [Wikipedia:Zygomaticotemporal_nerve] synonym: "zygomaticotemporal branch of zygomatic nerve" EXACT [FMA:52972] xref: FMA:52972 xref: SCTID:280243001 xref: Wikipedia:Zygomaticotemporal_nerve is_a: UBERON:0011779 ! nerve of head region relationship: RO:0002380 UBERON:0000377 ! branching part of maxillary nerve property_value: skos:prefLabel "zygomaticotemporal nerve" xsd:string [Term] id: UBERON:0036267 name: vulval vein xref: SCTID:279975006 is_a: UBERON:0001638 ! vein intersection_of: UBERON:0001638 ! vein intersection_of: RO:0020102 UBERON:0000997 ! vessel drains blood from mammalian vulva relationship: RO:0020102 UBERON:0000997 ! vessel drains blood from mammalian vulva [Term] id: UBERON:0036268 name: pelvic vein xref: SCTID:13152008 is_a: UBERON:0001638 ! vein intersection_of: UBERON:0001638 ! vein intersection_of: RO:0020102 UBERON:0002355 ! vessel drains blood from pelvic region of trunk relationship: RO:0020102 UBERON:0002355 ! vessel drains blood from pelvic region of trunk [Term] id: UBERON:0036269 name: penis blood vessel synonym: "penis vasculature" RELATED [] synonym: "vasculature of penis" RELATED [EMAPA:30807] xref: EMAPA:30807 xref: SCTID:363673006 is_a: UBERON:0001981 ! blood vessel intersection_of: UBERON:0001981 ! blood vessel intersection_of: RO:0002170 UBERON:0000989 ! connected to penis relationship: RO:0002170 UBERON:0000989 ! connected to penis [Term] id: UBERON:0036285 name: wall of left ventricle def: "Wall of ventricle which is continuous with the wall of aorta." [FMA:9556] synonym: "left ventricular wall" EXACT [FMA:9556] xref: FMA:9556 is_a: UBERON:0004784 {source="FMA"} ! heart ventricle wall intersection_of: UBERON:0004784 ! heart ventricle wall intersection_of: BFO:0000050 UBERON:0002084 ! part of heart left ventricle relationship: BFO:0000050 UBERON:0002084 {source="FMA"} ! part of heart left ventricle property_value: skos:prefLabel "wall of left ventricle" xsd:string [Term] id: UBERON:0036286 name: wall of right ventricle def: "Wall of ventricle which is continuous with the wall of pulmonary trunk." [FMA:9533] synonym: "right ventricular wall" EXACT [FMA:9533] xref: FMA:9533 is_a: UBERON:0004784 {source="FMA"} ! heart ventricle wall intersection_of: UBERON:0004784 ! heart ventricle wall intersection_of: BFO:0000050 UBERON:0002080 ! part of heart right ventricle relationship: BFO:0000050 UBERON:0002080 {source="FMA"} ! part of heart right ventricle property_value: skos:prefLabel "wall of right ventricle" xsd:string [Term] id: UBERON:0036288 name: anterior wall of left ventricle xref: FMA:9560 is_a: UBERON:0036285 ! wall of left ventricle intersection_of: UBERON:0004784 ! heart ventricle wall intersection_of: BSPO:0000123 UBERON:0002084 ! heart left ventricle relationship: BFO:0000050 UBERON:0036285 {source="FMA"} ! part of wall of left ventricle relationship: BSPO:0000123 UBERON:0002084 ! heart left ventricle property_value: skos:prefLabel "anterior wall of left ventricle" xsd:string [Term] id: UBERON:0036289 name: anterior wall of right ventricle def: "Region of wall of right ventricle which is continuous with the lateral and septal walls of right ventricle." [FMA:9553] xref: FMA:9553 is_a: UBERON:0036286 ! wall of right ventricle intersection_of: UBERON:0004784 ! heart ventricle wall intersection_of: BSPO:0000123 UBERON:0002080 ! heart right ventricle relationship: BSPO:0000123 UBERON:0002080 ! heart right ventricle property_value: skos:prefLabel "anterior wall of right ventricle" xsd:string [Term] id: UBERON:0036290 name: myocardium of anterior wall of left ventricle xref: FMA:87177 is_a: UBERON:0006566 ! left ventricle myocardium intersection_of: UBERON:0002349 ! myocardium intersection_of: BFO:0000050 UBERON:0036288 ! part of anterior wall of left ventricle relationship: BFO:0000050 UBERON:0036288 ! part of anterior wall of left ventricle property_value: skos:prefLabel "myocardium of anterior wall of left ventricle" xsd:string [Term] id: UBERON:0036291 name: myocardium of anterior wall of right ventricle xref: FMA:260877 is_a: UBERON:0006567 ! right ventricle myocardium intersection_of: UBERON:0002349 ! myocardium intersection_of: BFO:0000050 UBERON:0036289 ! part of anterior wall of right ventricle relationship: BFO:0000050 UBERON:0036289 ! part of anterior wall of right ventricle property_value: skos:prefLabel "myocardium of anterior wall of right ventricle" xsd:string [Term] id: UBERON:0036294 name: mucosa of lip def: "A mucosa that is part of a lip region [Automatically generated definition]." [OBOL:automatic] synonym: "labial mucosa" EXACT [UBERON:cjm] xref: NCIT:C12226 is_a: UBERON:0003729 ! mouth mucosa intersection_of: UBERON:0000344 ! mucosa intersection_of: BFO:0000050 UBERON:0001833 ! part of lip relationship: BFO:0000050 UBERON:0001833 ! part of lip property_value: skos:prefLabel "mucosa of lip" xsd:string [Term] id: UBERON:0036295 name: renal pelvis/ureter def: "The upper tract of the renal system. The renal pelvis is the large cavity in the middle of each kidney. Urine drains from each kidney through a long tube called the ureter, into the bladder, where it is stored until it is passed from the body through the urethra." [NCIT:C54419] subset: human_reference_atlas synonym: "renal pelvis and ureter" EXACT [] synonym: "renal pelvis plus ureter" EXACT [] xref: NCIT:C54419 is_a: BFO:0000004 is_a: UBERON:0000477 ! anatomical cluster relationship: BFO:0000050 UBERON:0011143 {source="NCIT"} ! part of upper urinary tract property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0036301 name: vasculature of spleen xref: FMA:225251 xref: SCTID:297287005 is_a: UBERON:0002201 ! vasculature of trunk is_a: UBERON:0006876 {source="FMA"} ! vasculature of organ intersection_of: UBERON:0002049 ! vasculature intersection_of: BFO:0000050 UBERON:0002106 ! part of spleen relationship: BFO:0000050 UBERON:0002106 ! part of spleen property_value: skos:prefLabel "vasculature of spleen" xsd:string [Term] id: UBERON:0036302 name: vasculature of central nervous system plus retina is_a: UBERON:0002049 ! vasculature union_of: UBERON:0004864 ! vasculature of retina union_of: UBERON:0036303 ! vasculature of central nervous system property_value: skos:prefLabel "vasculature of central nervous system plus retina" xsd:string [Term] id: UBERON:0036303 name: vasculature of central nervous system xref: FMA:259905 is_a: UBERON:0036302 ! vasculature of central nervous system plus retina intersection_of: UBERON:0002049 ! vasculature intersection_of: BFO:0000050 UBERON:0001017 ! part of central nervous system relationship: BFO:0000050 UBERON:0001017 ! part of central nervous system property_value: skos:prefLabel "vasculature of central nervous system" xsd:string [Term] id: UBERON:0036304 name: anatomical border def: "An anatomical structure that is located along the line dividing two regions of an anatomical structure." [UBERON:cjm] subset: common_anatomy is_a: UBERON:0000061 ! anatomical structure property_value: RO:0002175 NCBITaxon:33090 property_value: RO:0002175 NCBITaxon:33208 property_value: RO:0002175 NCBITaxon:4751 [Term] id: UBERON:0036328 name: wall of coronary artery synonym: "coronary arterial wall" EXACT [FMA:14179] xref: FMA:14179 is_a: UBERON:0000415 {source="FMA"} ! artery wall is_a: UBERON:0037144 ! wall of heart intersection_of: UBERON:0000060 ! anatomical wall intersection_of: BFO:0000050 UBERON:0001621 ! part of coronary artery relationship: BFO:0000050 UBERON:0001621 {source="FMA"} ! part of coronary artery [Term] id: UBERON:0036337 name: wall of appendix synonym: "appendix wall" EXACT [FMA:14621] synonym: "wall of vermiform appendix" EXACT [FMA:14621] xref: FMA:14621 is_a: UBERON:0001169 ! wall of large intestine intersection_of: UBERON:0000060 ! anatomical wall intersection_of: BFO:0000050 UBERON:0001154 ! part of vermiform appendix relationship: BFO:0000050 UBERON:0001154 {source="FMA"} ! part of vermiform appendix relationship: BFO:0000050 UBERON:0001169 {source="FMA"} ! part of wall of large intestine [Term] id: UBERON:0036343 name: wall of gallbladder synonym: "gallbladder wall" EXACT [FMA:14657] xref: FMA:14657 is_a: UBERON:0003697 ! abdominal wall intersection_of: UBERON:0000060 ! anatomical wall intersection_of: BFO:0000050 UBERON:0002110 ! part of gallbladder relationship: BFO:0000050 UBERON:0002110 {source="FMA"} ! part of gallbladder property_value: skos:prefLabel "wall of gallbladder" xsd:string [Term] id: UBERON:0036351 name: wall of brachiocephalic artery synonym: "brachiocephalic arterial wall" EXACT [FMA:15089] xref: FMA:15089 is_a: UBERON:0000415 {source="FMA"} ! artery wall intersection_of: UBERON:0000060 ! anatomical wall intersection_of: BFO:0000050 UBERON:0001529 ! part of brachiocephalic artery relationship: BFO:0000050 UBERON:0001529 {source="FMA"} ! part of brachiocephalic artery property_value: skos:prefLabel "wall of brachiocephalic artery" xsd:string [Term] id: UBERON:0036352 name: wall of subclavian artery synonym: "subclavian arterial wall" EXACT [FMA:15090] xref: FMA:15090 is_a: UBERON:0000415 {source="FMA"} ! artery wall intersection_of: UBERON:0000060 ! anatomical wall intersection_of: BFO:0000050 UBERON:0001533 ! part of subclavian artery relationship: BFO:0000050 UBERON:0001533 {source="FMA"} ! part of subclavian artery property_value: skos:prefLabel "wall of subclavian artery" xsd:string [Term] id: UBERON:0036362 name: wall of anal canal synonym: "anal canal wall" EXACT [FMA:15704] xref: FMA:15704 is_a: UBERON:0001169 ! wall of large intestine intersection_of: UBERON:0000060 ! anatomical wall intersection_of: BFO:0000050 UBERON:0000159 ! part of anal canal intersection_of: BFO:0000050 UBERON:0001007 ! part of digestive system relationship: BFO:0000050 UBERON:0000159 {source="FMA"} ! part of anal canal property_value: skos:prefLabel "wall of anal canal" xsd:string [Term] id: UBERON:0036375 name: wall of right ureter synonym: "right ureteral wall" EXACT [FMA:15889] xref: FMA:15889 is_a: UBERON:0009916 {source="FMA"} ! wall of ureter intersection_of: UBERON:0000060 ! anatomical wall intersection_of: BFO:0000050 UBERON:0001222 ! part of right ureter relationship: BFO:0000050 UBERON:0001222 {source="FMA"} ! part of right ureter [Term] id: UBERON:0036376 name: wall of left ureter subset: human_reference_atlas synonym: "left ureteral wall" EXACT [FMA:15890] xref: FMA:15890 is_a: UBERON:0009916 {source="FMA"} ! wall of ureter intersection_of: UBERON:0000060 ! anatomical wall intersection_of: BFO:0000050 UBERON:0001223 ! part of left ureter relationship: BFO:0000050 UBERON:0001223 {source="FMA"} ! part of left ureter property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0036422 name: wall of pulmonary artery synonym: "pulmonary arterial wall" EXACT [FMA:18211] xref: FMA:18211 is_a: UBERON:0000415 {source="FMA"} ! artery wall intersection_of: UBERON:0000060 ! anatomical wall intersection_of: BFO:0000050 UBERON:0002012 ! part of pulmonary artery relationship: BFO:0000050 UBERON:0002012 {source="FMA"} ! part of pulmonary artery property_value: skos:prefLabel "wall of pulmonary artery" xsd:string [Term] id: UBERON:0036441 name: wall of fallopian tube synonym: "uterine tube wall" EXACT [FMA:18303] synonym: "wall of oviduct" EXACT [FMA:18303] synonym: "wall of uterine tube" EXACT [] xref: FMA:18303 is_a: UBERON:0000060 {source="FMA"} ! anatomical wall is_a: UBERON:0005156 ! reproductive structure intersection_of: UBERON:0000060 ! anatomical wall intersection_of: BFO:0000050 UBERON:0003889 ! part of fallopian tube relationship: BFO:0000050 UBERON:0003889 {source="FMA"} ! part of fallopian tube [Term] id: UBERON:0036521 name: wall of urethra synonym: "urethral wall" EXACT [FMA:19779] xref: FMA:19779 is_a: UBERON:0000060 {source="FMA"} ! anatomical wall intersection_of: UBERON:0000060 ! anatomical wall intersection_of: BFO:0000050 UBERON:0000057 ! part of urethra relationship: BFO:0000050 UBERON:0000057 {source="FMA"} ! part of urethra [Term] id: UBERON:0036523 name: wall of vagina synonym: "vaginal wall" EXACT [FMA:19971] xref: FMA:19971 is_a: UBERON:0000060 {source="FMA"} ! anatomical wall is_a: UBERON:0005156 ! reproductive structure intersection_of: UBERON:0000060 ! anatomical wall intersection_of: BFO:0000050 UBERON:0000996 ! part of vagina relationship: BFO:0000050 UBERON:0000996 {source="FMA"} ! part of vagina [Term] id: UBERON:0036553 name: wall of synovial tendon sheath xref: FMA:231590 is_a: UBERON:0000042 {source="FMA"} ! serous membrane is_a: UBERON:0000060 ! anatomical wall intersection_of: UBERON:0000060 ! anatomical wall intersection_of: BFO:0000050 UBERON:0000304 ! part of tendon sheath relationship: BFO:0000050 UBERON:0000304 {source="FMA"} ! part of tendon sheath property_value: skos:prefLabel "wall of synovial tendon sheath" xsd:string [Term] id: UBERON:0036654 name: wall of lateral ventricle xref: FMA:242772 is_a: UBERON:0036661 ! wall of ventricular system of brain intersection_of: UBERON:0000060 ! anatomical wall intersection_of: BFO:0000050 UBERON:0002285 ! part of telencephalic ventricle relationship: BFO:0000050 UBERON:0002285 {source="FMA"} ! part of telencephalic ventricle property_value: skos:prefLabel "wall of lateral ventricle" xsd:string [Term] id: UBERON:0036656 name: wall of third ventricle xref: FMA:242776 is_a: UBERON:0036661 ! wall of ventricular system of brain intersection_of: UBERON:0000060 ! anatomical wall intersection_of: BFO:0000050 UBERON:0002286 ! part of third ventricle relationship: BFO:0000050 UBERON:0002286 {source="FMA"} ! part of third ventricle property_value: skos:prefLabel "wall of third ventricle" xsd:string [Term] id: UBERON:0036657 name: wall of fourth ventricle xref: FMA:242778 is_a: UBERON:0036661 ! wall of ventricular system of brain intersection_of: UBERON:0000060 ! anatomical wall intersection_of: BFO:0000050 UBERON:0002422 ! part of fourth ventricle relationship: BFO:0000050 UBERON:0002422 {source="FMA"} ! part of fourth ventricle property_value: skos:prefLabel "wall of fourth ventricle" xsd:string [Term] id: UBERON:0036658 name: wall of central canal of spinal cord synonym: "wall of central canal" EXACT [FMA:242780] xref: FMA:242780 is_a: UBERON:0000060 ! anatomical wall is_a: UBERON:0005358 {source="FMA"} ! ventricle of nervous system intersection_of: UBERON:0000060 ! anatomical wall intersection_of: BFO:0000050 UBERON:0002291 ! part of central canal of spinal cord relationship: BFO:0000050 UBERON:0002291 {source="FMA"} ! part of central canal of spinal cord property_value: skos:prefLabel "wall of central canal of spinal cord" xsd:string [Term] id: UBERON:0036661 name: wall of ventricular system of brain xref: FMA:242841 is_a: UBERON:0000060 ! anatomical wall is_a: UBERON:0005358 {source="FMA"} ! ventricle of nervous system intersection_of: UBERON:0000060 ! anatomical wall intersection_of: BFO:0000050 UBERON:0005282 ! part of ventricular system of brain relationship: BFO:0000050 UBERON:0005282 {source="FMA"} ! part of ventricular system of brain property_value: skos:prefLabel "wall of ventricular system of brain" xsd:string [Term] id: UBERON:0036925 name: wall of eyeball synonym: "eyeball wall" EXACT [FMA:58098] xref: FMA:58098 is_a: UBERON:0000060 {source="FMA"} ! anatomical wall intersection_of: UBERON:0000060 ! anatomical wall intersection_of: BFO:0000050 UBERON:0010230 ! part of eyeball of camera-type eye relationship: BFO:0000050 UBERON:0010230 {source="FMA"} ! part of eyeball of camera-type eye property_value: skos:prefLabel "wall of eyeball" xsd:string [Term] id: UBERON:0036990 name: wall of pharyngotympanic tube synonym: "pharyngotympanic tube wall" EXACT [FMA:60069] xref: FMA:60069 is_a: UBERON:0000060 {source="FMA"} ! anatomical wall intersection_of: UBERON:0000060 ! anatomical wall intersection_of: BFO:0000050 UBERON:0002393 ! part of pharyngotympanic tube relationship: BFO:0000050 UBERON:0002393 {source="FMA"} ! part of pharyngotympanic tube [Term] id: UBERON:0037089 name: wall of orbit synonym: "orbit wall" EXACT [FMA:63144] xref: FMA:63144 is_a: UBERON:0000060 ! anatomical wall is_a: UBERON:0000075 {source="FMA"} ! subdivision of skeletal system intersection_of: UBERON:0000060 ! anatomical wall intersection_of: BFO:0000050 UBERON:0001697 ! part of orbit of skull relationship: BFO:0000050 UBERON:0001697 {source="FMA"} ! part of orbit of skull property_value: skos:prefLabel "wall of orbit" xsd:string [Term] id: UBERON:0037094 name: wall of common carotid artery synonym: "common carotid arterial wall" EXACT [FMA:66284] xref: FMA:66284 is_a: UBERON:0000415 {source="FMA"} ! artery wall intersection_of: UBERON:0000060 ! anatomical wall intersection_of: BFO:0000050 UBERON:0001530 ! part of common carotid artery plus branches relationship: BFO:0000050 UBERON:0001530 {source="FMA"} ! part of common carotid artery plus branches property_value: skos:prefLabel "wall of common carotid artery" xsd:string [Term] id: UBERON:0037144 name: wall of heart def: "Wall of organ which has as its parts the endocardium, myocardium , epicardium, and the cardiac septum, surrounded by the pericardial sac proper and is continuous with the walls of the systemic and pulmonary arterial and venous trees." [FMA:7274] synonym: "cardiac wall" EXACT [FMA:7274] xref: FMA:7274 is_a: UBERON:0000060 {source="FMA"} ! anatomical wall intersection_of: UBERON:0000060 ! anatomical wall intersection_of: BFO:0000050 UBERON:0000948 ! part of heart relationship: BFO:0000050 UBERON:0000948 {source="FMA"} ! part of heart relationship: RO:0002371 UBERON:0002406 {source="FMA"} ! attached to pericardial sac relationship: RO:0002371 UBERON:0004292 {source="FMA"} ! attached to cardiac skeleton property_value: skos:prefLabel "wall of heart" xsd:string [Term] id: UBERON:0037191 name: wall of membranous labyrinth synonym: "membranous labyrinth wall" EXACT [FMA:79837] xref: FMA:79837 is_a: UBERON:0000060 {source="FMA"} ! anatomical wall intersection_of: UBERON:0000060 ! anatomical wall intersection_of: BFO:0000050 UBERON:0001849 ! part of membranous labyrinth relationship: BFO:0000050 UBERON:0001849 {source="FMA"} ! part of membranous labyrinth property_value: skos:prefLabel "wall of membranous labyrinth" xsd:string [Term] id: UBERON:0037237 name: wall of lacrimal duct synonym: "lacrimal ductal wall" EXACT [FMA:85375] xref: FMA:85375 is_a: UBERON:0000060 {source="FMA"} ! anatomical wall intersection_of: UBERON:0000060 ! anatomical wall intersection_of: BFO:0000050 UBERON:0001850 ! part of lacrimal drainage system relationship: BFO:0000050 UBERON:0001850 {source="FMA"} ! part of lacrimal drainage system [Term] id: UBERON:0037447 name: wall of male urethra synonym: "male urethral wall" EXACT [FMA:19676] xref: FMA:19676 is_a: UBERON:0036521 {source="FMA"} ! wall of urethra intersection_of: UBERON:0000060 ! anatomical wall intersection_of: BFO:0000050 UBERON:0001333 ! part of male urethra relationship: BFO:0000050 UBERON:0001333 {source="FMA"} ! part of male urethra [Term] id: UBERON:0037455 name: wall of female urethra synonym: "female urethral wall" EXACT [FMA:19780] xref: FMA:19780 is_a: UBERON:0036521 {source="FMA"} ! wall of urethra intersection_of: UBERON:0000060 ! anatomical wall intersection_of: BFO:0000050 UBERON:0001334 ! part of female urethra relationship: BFO:0000050 UBERON:0001334 {source="FMA"} ! part of female urethra [Term] id: UBERON:0037458 name: hair of neck synonym: "neck hair" EXACT [FMA:54242] xref: FMA:54242 is_a: UBERON:0001037 ! strand of hair intersection_of: UBERON:0001037 ! strand of hair intersection_of: BFO:0000050 UBERON:0000974 ! part of neck relationship: BFO:0000050 UBERON:0000974 ! part of neck [Term] id: UBERON:0037459 name: hair of limb synonym: "limb hair" EXACT [FMA:54243] xref: FMA:54243 is_a: UBERON:0001037 ! strand of hair intersection_of: UBERON:0001037 ! strand of hair intersection_of: BFO:0000050 UBERON:0002101 ! part of limb relationship: BFO:0000050 UBERON:0002101 ! part of limb [Term] id: UBERON:0039175 name: subarachnoid space of brain xref: FMA:322073 is_a: UBERON:0000315 {source="FMA"} ! subarachnoid space intersection_of: UBERON:0000315 ! subarachnoid space intersection_of: BFO:0000050 UBERON:0000955 ! part of brain relationship: BFO:0000050 UBERON:0000955 ! part of brain property_value: skos:prefLabel "subarachnoid space of brain" xsd:string [Term] id: UBERON:0039176 name: subarachnoid space of spinal cord xref: FMA:322074 is_a: UBERON:0000315 {source="FMA"} ! subarachnoid space intersection_of: UBERON:0000315 ! subarachnoid space intersection_of: BFO:0000050 UBERON:0002240 ! part of spinal cord relationship: BFO:0000050 UBERON:0002240 ! part of spinal cord property_value: skos:prefLabel "subarachnoid space of spinal cord" xsd:string [Term] id: UBERON:0039222 name: cystic artery def: "An artery that supplies oxygenated blood to the cystic duct." [http://orcid.org/0000-0002-6601-2165, https://en.wikipedia.org/wiki/Cystic_artery] synonym: "cholecystic artery" EXACT [FMA:14835] xref: FMA:14835 is_a: UBERON:0001637 ! artery is_a: UBERON:0015796 ! liver blood vessel intersection_of: UBERON:0001637 ! artery intersection_of: RO:0020101 UBERON:0001152 ! vessel supplies blood to cystic duct relationship: BFO:0000050 UBERON:0015482 {source="FMA", source="Wikipedia"} ! part of right hepatic artery relationship: RO:0020101 UBERON:0001152 ! vessel supplies blood to cystic duct property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/blood-vasculature-female/v1.3/assets/3d-vh-f-blood-vasculature.glb" xsd:anyURI property_value: foaf:depiction "https://cdn.humanatlas.io/digital-objects/ref-organ/blood-vasculature-male/v1.3/assets/3d-vh-m-blood-vasculature.glb" xsd:anyURI property_value: skos:prefLabel "cystic artery" xsd:string [Term] id: UBERON:0039228 name: sigmoid vein xref: FMA:15395 is_a: UBERON:0001638 ! vein intersection_of: UBERON:0001638 ! vein intersection_of: RO:0020102 UBERON:0001159 ! vessel drains blood from sigmoid colon relationship: RO:0002376 UBERON:0001215 {source="FMA"} ! tributary of inferior mesenteric vein relationship: RO:0020102 UBERON:0001159 ! vessel drains blood from sigmoid colon property_value: skos:prefLabel "sigmoid vein" xsd:string [Term] id: UBERON:0039261 name: pancreatic artery xref: FMA:70471 is_a: UBERON:0001637 ! artery intersection_of: UBERON:0001637 ! artery intersection_of: RO:0020101 UBERON:0001264 ! vessel supplies blood to pancreas relationship: RO:0002252 UBERON:0001194 ! connecting branch of splenic artery relationship: RO:0020101 UBERON:0001264 ! vessel supplies blood to pancreas property_value: skos:prefLabel "pancreatic artery" xsd:string [Term] id: UBERON:0039355 name: urethral artery synonym: "arteria urethralis" EXACT OMO:0003011 [A12.2.15.042] xref: FMA:20903 is_a: UBERON:0001637 ! artery intersection_of: UBERON:0001637 ! artery intersection_of: RO:0020101 UBERON:0000057 ! vessel supplies blood to urethra relationship: RO:0020101 UBERON:0000057 ! vessel supplies blood to urethra [Term] id: UBERON:0039377 name: urethral vein def: "A vein that drains the urethra." [UBERON:cjm] xref: FMA:21270 is_a: UBERON:0001638 ! vein intersection_of: UBERON:0001638 ! vein intersection_of: RO:0020102 UBERON:0000057 ! vessel drains blood from urethra relationship: RO:0002376 UBERON:0018252 {source="FMA"} ! tributary of internal pudendal vein relationship: RO:0020102 UBERON:0000057 ! vessel drains blood from urethra [Term] id: UBERON:0039856 name: right ovarian vein def: "Ovarian vein, each instance of which is a tributary of some inferior vena cava that drains the right pampiniform plexus of some broad ligament." [FMA:14342] xref: FMA:14342 is_a: UBERON:0001145 {source="FMA"} ! ovarian vein intersection_of: UBERON:0001145 ! ovarian vein intersection_of: RO:0020102 UBERON:0002118 ! vessel drains blood from right ovary relationship: RO:0002376 UBERON:0001072 {source="FMA"} ! tributary of inferior vena cava relationship: RO:0020102 UBERON:0002118 ! vessel drains blood from right ovary property_value: skos:prefLabel "right ovarian vein" xsd:string [Term] id: UBERON:0039857 name: left ovarian vein def: "Ovarian vein, each instance of which is a tributary of some left renal vein that drains the left pampiniform plexus of some broad ligament." [FMA:14347] xref: FMA:14347 is_a: UBERON:0001145 {source="FMA"} ! ovarian vein intersection_of: UBERON:0001145 ! ovarian vein intersection_of: RO:0020102 UBERON:0002119 ! vessel drains blood from left ovary relationship: RO:0020102 UBERON:0002119 ! vessel drains blood from left ovary property_value: skos:prefLabel "left ovarian vein" xsd:string [Term] id: UBERON:1000004 name: collection of hair on external ear def: "A collection of hairs that grows on the external ear." [https://github.com/obophenotype/uberon/issues/34, UBERON:EJS] subset: phenotype_rcn synonym: "external ear hair" RELATED [] is_a: UBERON:0014382 ! collection of hairs on head or neck intersection_of: UBERON:0010164 ! collection of hairs intersection_of: BFO:0000050 UBERON:0001691 ! part of external ear relationship: BFO:0000050 UBERON:0001691 ! part of external ear relationship: RO:0002473 UBERON:0022279 ! composed primarily of strand of hair on external ear property_value: terms:contributor https://orcid.org/0000-0002-6601-2165 property_value: terms:contributor https://orcid.org/0000-0002-9611-1279 [Term] id: UBERON:1000021 name: skin of face def: "A zone of skin that is part of the face." [https://github.com/obophenotype/uberon/issues/34, UBERON:EJS] subset: pheno_slim subset: phenotype_rcn synonym: "face skin" EXACT [EMAPA:36657, FMA:24758] synonym: "facial skin" RELATED [] xref: EMAPA:36657 xref: FMA:24758 xref: NCIT:C33561 xref: SCTID:361703006 xref: UMLS:C0222084 {source="ncithesaurus:Skin_of_the_Face"} is_a: UBERON:0001084 ! skin of head intersection_of: UBERON:0000014 ! zone of skin intersection_of: BFO:0000050 UBERON:0001456 ! part of face relationship: BFO:0000050 UBERON:0001456 ! part of face property_value: skos:prefLabel "skin of face" xsd:string property_value: terms:contributor https://orcid.org/0000-0002-6601-2165 property_value: terms:contributor https://orcid.org/0000-0002-9611-1279 creation_date: 2012-02-05T05:23:01Z [Term] id: UBERON:1000023 name: spleen pulp def: "The parenchyma of the spleen, consisting of lymphocytes and macrophages. It lies between the splenic trabecula. Red pulp is the part suffused with blood and white pulp consists of areas of lymphatic tissue where there are sleeves of lymphocytes and macrophages." [ncithesaurus:Splenic_Pulp] subset: human_reference_atlas synonym: "Malpighian corpuscles" EXACT [FMA:15845] synonym: "pulp of spleen" EXACT [] synonym: "splenic pulp" EXACT [] xref: EMAPA:35805 xref: FMA:15845 xref: MA:0002487 xref: NCIT:C33603 xref: SCTID:13515001 xref: UMLS:C0229691 {source="ncithesaurus:Splenic_Pulp"} is_a: UBERON:0000064 ! organ part relationship: BFO:0000050 UBERON:1000024 {source="FMA"} ! part of parenchyma of spleen property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:1000024 name: parenchyma of spleen def: "A parenchyma that is part of a spleen." [OBOL:automatic] synonym: "splenic parenchyma" EXACT [FMA:16029] xref: FMA:16029 is_a: UBERON:0000353 ! parenchyma intersection_of: UBERON:0000353 ! parenchyma intersection_of: BFO:0000050 UBERON:0002106 ! part of spleen relationship: BFO:0000050 UBERON:0002106 ! part of spleen property_value: skos:prefLabel "parenchyma of spleen" xsd:string [Term] id: UBERON:1100000 name: digestive tract junction def: "An anatomical junction between two parts of the digestive tract." [https://orcid.org/0000-0002-7073-9172] is_a: UBERON:0007651 ! anatomical junction intersection_of: UBERON:0007651 ! anatomical junction intersection_of: RO:0002176 UBERON:0004921 ! connects subdivision of digestive tract relationship: RO:0002176 UBERON:0004921 ! connects subdivision of digestive tract property_value: skos:prefLabel "digestive tract junction" xsd:string property_value: terms:contributor https://orcid.org/0000-0002-7073-9172 creation_date: 2021-02-05T11:19:31Z [Term] id: UBERON:2000120 name: lateral line ganglion def: "Ganglion that develops from a cranial ectodermal placode and contains sensory neurons that innervate a lateral line." [ZFA:0000120, ZFA:curator] subset: efo_slim synonym: "lateral line ganglia" EXACT OMO:0003004 [TAO:0000120] synonym: "LLG" EXACT OMO:0003000 [TAO:0000120] xref: EFO:0003493 xref: TAO:0000120 xref: XAO:0004457 xref: ZFA:0000120 is_a: UBERON:0001714 ! cranial ganglion is_a: UBERON:0004121 ! ectoderm-derived structure intersection_of: UBERON:0001714 ! cranial ganglion intersection_of: extends_fibers_into UBERON:0008906 ! lateral line nerve relationship: BFO:0000050 UBERON:0002540 ! part of lateral line system relationship: extends_fibers_into UBERON:0008906 ! lateral line nerve relationship: RO:0002202 UBERON:0009128 ! develops from lateral line placode [Term] id: UBERON:2000175 name: posterior lateral line nerve def: "Cranial nerve which enters the brain between cranial nerves VIII and IX; contains afferents and sensory efferents to the posterior lateral line ganglion and middle ganglion. Fibers from the posterior lateral line ganglion innervate the occipital dorsal lateral line and trunk lateral lines." [ZFIN:curator] synonym: "caudal lateral line nerve" EXACT [TAO:0000175] xref: ZFA:0000175 is_a: UBERON:0008906 ! lateral line nerve relationship: BFO:0000050 UBERON:2001471 ! part of posterior lateral line system [Term] id: UBERON:2000228 name: lateral line primordium synonym: "lateral line primordia" EXACT OMO:0003004 [TAO:0000228] synonym: "llp" EXACT [TAO:0000228] xref: ZFA:0000228 is_a: UBERON:0000479 ! tissue relationship: BFO:0000050 UBERON:0002540 ! part of lateral line system [Term] id: UBERON:2000238 name: olfactory tract linking bulb to ipsilateral ventral telencephalon xref: ZFA:0000238 is_a: UBERON:0002265 ! olfactory tract intersection_of: UBERON:0002265 ! olfactory tract intersection_of: RO:0002131 UBERON:0000204 ! overlaps ventral part of telencephalon relationship: RO:0002131 UBERON:0000204 ! overlaps ventral part of telencephalon property_value: skos:prefLabel "olfactory tract linking bulb to ipsilateral ventral telencephalon" xsd:string [Term] id: UBERON:2000425 name: anterior lateral line nerve def: "Cranial nerve which enters the brain between cranial nerves VI and VII; contains afferents and sensory efferents to the anterior lateral line ganglia." [ZFIN:curator] synonym: "rostral lateral line nerve" EXACT [TAO:0000425] xref: ZFA:0000425 is_a: UBERON:0008906 ! lateral line nerve relationship: BFO:0000050 UBERON:2001468 ! part of anterior lateral line system [Term] id: UBERON:2000940 name: posterior lateral line neuromast def: "Neuromast that is part of the posterior lateral line. Kimmel et al, 1995. (Also see Anatomical Atlas entry for lateral line by T. Whitfield.)." [ZFIN:curator] synonym: "neuromast posterior" EXACT [TAO:0000940] synonym: "neuromasts posterior" EXACT OMO:0003004 [TAO:0000940] xref: ZFA:0000940 is_a: UBERON:0008904 ! neuromast relationship: BFO:0000050 UBERON:0006334 ! part of posterior lateral line relationship: RO:0002202 UBERON:2001157 ! develops from posterior lateral line primordium [Term] id: UBERON:2001053 name: future internal carotid artery synonym: "PICA" EXACT [TAO:0001053] synonym: "primitive internal carotid artery" EXACT [ZFA:0001053] xref: EFO:0003612 xref: TAO:0001053 xref: ZFA:0001053 is_a: UBERON:0004573 ! systemic artery relationship: BFO:0000050 UBERON:0001530 {source="EHDAA2"} ! part of common carotid artery plus branches relationship: RO:0002202 UBERON:0004363 ! develops from pharyngeal arch artery property_value: skos:prefLabel "future internal carotid artery" xsd:string [Term] id: UBERON:2001073 name: axial vasculature xref: ZFA:0001073 is_a: UBERON:0002049 ! vasculature property_value: skos:prefLabel "axial vasculature" xsd:string [Term] id: UBERON:2001156 name: posterior lateral line placode xref: ZFA:0001156 is_a: UBERON:0003067 ! dorsolateral placode disjoint_from: UBERON:2001316 {source="lexical"} ! anterior lateral line placode relationship: BFO:0000050 UBERON:2001471 ! part of posterior lateral line system [Term] id: UBERON:2001157 name: posterior lateral line primordium def: "A migrating group of cells originating from the posterior lateral line placode. The primordium deposits seven to nine neuromasts and interneuromasts between them during its posterior migration to the tail. Gompel et al, 2001." [ZFIN:curator] synonym: "posterior lateral line primordia" EXACT OMO:0003004 [TAO:0001157] xref: ZFA:0001157 is_a: UBERON:0004121 ! ectoderm-derived structure is_a: UBERON:2000228 ! lateral line primordium relationship: BFO:0000050 UBERON:2001471 ! part of posterior lateral line system relationship: RO:0002202 UBERON:2001156 ! develops from posterior lateral line placode [Term] id: UBERON:2001269 name: regenerating fin/limb def: "Fin or limb undergoing the process of regeneration." [https://orcid.org/0000-0002-6601-2165] subset: efo_slim synonym: "regenerating fins" NARROW OMO:0003004 [ZFA:0001269] xref: EFO:0003657 xref: TAO:0001269 xref: ZFA:0001269 is_a: UBERON:0004708 ! paired limb/fin is_a: UBERON:0007567 ! regenerating anatomical structure intersection_of: UBERON:0004708 ! paired limb/fin intersection_of: RO:0000056 GO:0031099 ! participates in regeneration [Term] id: UBERON:2001314 name: posterior lateral line ganglion def: "The posterior lateral line ganglion develops from a cranial ectodermal placode and contains sensory neurons that innervate the posterior lateral line system." [ZFIN:curator] xref: ZFA:0001314 is_a: UBERON:2000120 ! lateral line ganglion disjoint_from: UBERON:2001391 {source="lexical"} ! anterior lateral line ganglion relationship: RO:0002202 UBERON:2001156 ! develops from posterior lateral line placode [Term] id: UBERON:2001316 name: anterior lateral line placode def: "Dorsolateral placode that gives rise to the anterior lateral line." [ZFA:0001316, ZFA:curator] subset: efo_slim synonym: "anterior lateral line placodes" RELATED OMO:0003004 [ZFA:0001316] synonym: "pre-auditory lateral line placode" RELATED [XAO:0004221] xref: EFO:0003461 xref: TAO:0001316 xref: XAO:0004221 xref: ZFA:0001316 is_a: UBERON:0003067 ! dorsolateral placode intersection_of: UBERON:0003067 ! dorsolateral placode intersection_of: BFO:0000050 UBERON:2001468 ! part of anterior lateral line system relationship: BFO:0000050 UBERON:2001468 ! part of anterior lateral line system [Term] id: UBERON:2001389 name: regeneration epithelium of fin/limb def: "An epithelium that is part of a regenerating fin/limb." [OBOL:automatic] subset: efo_slim synonym: "epidermal cap" BROAD [ZFA:0001389] synonym: "epidermal cap of fin" EXACT [] synonym: "wound epidermis" BROAD [ZFA:0001389] synonym: "wound epidermis of fin" EXACT [] synonym: "wound epithelium" BROAD [ZFA:0001389] synonym: "wound epithelium of fin" EXACT [] xref: EFO:0003682 xref: TAO:0001389 xref: ZFA:0001389 is_a: UBERON:0000483 ! epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: BFO:0000050 UBERON:2001269 ! part of regenerating fin/limb relationship: BFO:0000050 UBERON:2001269 ! part of regenerating fin/limb [Term] id: UBERON:2001391 name: anterior lateral line ganglion def: "The anteror lateral line ganglia develops from cranial ectodermal placodes and contain sensory neurons that innervate the anterior lateral line system." [ZFIN:curator] subset: efo_slim synonym: "anterior lateral line ganglia" RELATED OMO:0003004 [TAO:0001391] xref: EFO:0003683 xref: TAO:0001391 xref: ZFA:0001391 is_a: UBERON:2000120 ! lateral line ganglion intersection_of: UBERON:2000120 ! lateral line ganglion intersection_of: BFO:0000050 UBERON:2001468 ! part of anterior lateral line system relationship: BFO:0000050 UBERON:2001468 ! part of anterior lateral line system [Term] id: UBERON:2001431 name: primitive olfactory epithelium xref: ZFA:0001431 is_a: UBERON:0000483 ! epithelium is_a: UBERON:0005291 ! embryonic tissue relationship: BFO:0000050 UBERON:0003050 ! part of olfactory placode property_value: skos:prefLabel "primitive olfactory epithelium" xsd:string [Term] id: UBERON:2001457 name: postcranial axial cartilage def: "Cartilage which is part of the axial skeleton." [ZFIN:curator] xref: ZFA:0001457 is_a: UBERON:0007844 ! cartilage element intersection_of: UBERON:0007844 ! cartilage element intersection_of: BFO:0000050 UBERON:0002090 ! part of postcranial axial skeleton relationship: BFO:0000050 UBERON:0002090 ! part of postcranial axial skeleton property_value: skos:prefLabel "postcranial axial cartilage" xsd:string [Term] id: UBERON:2001468 name: anterior lateral line system def: "The anterior lateral line system develops from cranial ectodermal placodes, situated between the eye and the ear, that give rise to both the neuromasts and the anterior lateral line sensory nerves that innervate the neuromasts. The anterior lateral line system consists of small sensory patches (neuromasts) located superficially on the skin or just under the skin in fluid-filled canals on the head of all fishes and most amphibians and are innervated by several lateral line nerves, which project to the hindbrain. The anterior lateral line system is stimulated by local water displacements and vibrations, and detects propulsion of the fish through the water, as well as facilitating shoaling, prey capture, and predator and obstacle avoidance." [ZFIN:curator] subset: efo_slim xref: EFO:0003691 xref: TAO:0001468 xref: ZFA:0001468 is_a: UBERON:0002540 ! lateral line system disjoint_from: UBERON:2001471 {source="lexical"} ! posterior lateral line system [Term] id: UBERON:2001470 name: anterior lateral line def: "The anterior lateral line consists of small sensory patches (neuromasts) located superficially on the skin or just under the skin in fluid-filled canals on the head of all fishes and most amphibians. The anterior lateral line develops from cranial ectodermal placodes situated between the eye and ear." [ZFIN:curator] xref: TAO:0001470 xref: ZFA:0001470 is_a: UBERON:0010202 ! lateral line intersection_of: UBERON:0010202 ! lateral line intersection_of: BFO:0000050 UBERON:2001468 ! part of anterior lateral line system relationship: BFO:0000050 UBERON:2001468 ! part of anterior lateral line system relationship: RO:0002202 UBERON:2005117 ! develops from anterior lateral line primordium [Term] id: UBERON:2001471 name: posterior lateral line system def: "The posterior lateral line system develops from cranial ectodermal placodes, situated behind the ear, that give rise to both the neuromasts and the posterior lateral line sensory nerves that innervate the neuromasts. The posterior lateral line system consists of small sensory patches (neuromasts) located superficially on the skin or just under the skin in fluid-filled canals on the head of all fishes and most amphibians. The neuromasts are innervated by several lateral line nerves, which project primarily to the hindbrain. The posterior mechanosensory lateral line system is stimulated by local water displacements and vibrations, and detects propulsion of the fish through the water, as well as facilitating shoaling, prey capture, and predator and obstacle avoidance." [ZFIN:curator] xref: ZFA:0001471 is_a: UBERON:0002540 ! lateral line system [Term] id: UBERON:2001472 name: anterior lateral line neuromast def: "Neuromast that is part of the anterior lateral line. Kimmel et al, 1995. (Also see Anatomical Atlas entry for lateral line by T. Whitfield.)." [ZFIN:curator] synonym: "neuromast anterior" EXACT [TAO:0001472] xref: ZFA:0001472 is_a: UBERON:0008904 ! neuromast relationship: BFO:0000050 UBERON:2001470 ! part of anterior lateral line [Term] id: UBERON:2005117 name: anterior lateral line primordium def: "A migrating group of cells originating from an anterior lateral line placode. The primordium deposits neuromasts and interneuromasts between them during its migration." [ZFIN:curator] synonym: "anterior lateral line primordia" EXACT OMO:0003004 [TAO:0005117] xref: ZFA:0005117 is_a: UBERON:2000228 ! lateral line primordium relationship: BFO:0000050 UBERON:2001468 ! part of anterior lateral line system [Term] id: UBERON:2005227 name: protoneuromast synonym: "immature neuromast" RELATED [TAO:0005227] synonym: "proto neuromast" RELATED [TAO:0005227] synonym: "proto-neuromast" RELATED [TAO:0005227] xref: ZFA:0005227 is_a: BFO:0000004 is_a: UBERON:0000477 ! anatomical cluster relationship: BFO:0000050 UBERON:0002540 ! part of lateral line system [Term] id: UBERON:2005260 name: fenestrated capillary def: "Capillary that has pores in the endothelial cells (60-80 nm in diameter) that are spanned by a diaphragm of radially oriented fibrils and allow small molecules and limited amounts of protein to diffuse." [Wikipedia:Capillary#Types, Wikipedia:Fenestra_(histology)] synonym: "fenestrated blood vessel endothelium" BROAD [ZFA:0005260] synonym: "fenestrated capillary vessel" EXACT [FMA:63196] xref: FMA:63196 xref: NCIT:C32595 xref: TAO:0005260 xref: UMLS:C1179615 {source="ncithesaurus:Fenestrated_Capillary"} xref: Wikipedia:Capillary#Types xref: ZFA:0005260 is_a: UBERON:0001982 {source="FMA"} ! capillary is_a: UBERON:0004638 {source="ZFA"} ! blood vessel endothelium property_value: IAO:0000116 "the ZFA class from which this was derived is not explicitly classified as a capillary - need to verify for taxon histology differences" xsd:string [Term] id: UBERON:2007013 name: preplacodal ectoderm def: "Non neural ectoderm that surrounds the presumptive neural plate and gives rise to neurogenic placodes." [ZFIN:curator] xref: ZFA:0007013 is_a: UBERON:0005497 ! non-neural ectoderm property_value: skos:prefLabel "preplacodal ectoderm" xsd:string [Term] id: UBERON:3000961 name: external integument structure def: "Structures of the dermis, epidermis, glands and pigment cells recognizable on the external surfaces of the integument." [AAO:EJS] comment: Not clear how this differs from parent class. See https://github.com/obophenotype/uberon/issues/1305 is_a: UBERON:0003102 ! surface structure intersection_of: UBERON:0003102 ! surface structure intersection_of: BFO:0000050 UBERON:0002199 ! part of integument relationship: BFO:0000050 UBERON:0002199 ! part of integument property_value: skos:prefLabel "external integument structure" xsd:string [Term] id: UBERON:3000972 name: head external integument structure def: "Dermal, epidermal, glandular and pigment structures of the external head integument." [AAO:EJS] is_a: UBERON:3000961 ! external integument structure intersection_of: UBERON:3000961 ! external integument structure intersection_of: BFO:0000050 UBERON:0000033 ! part of head relationship: BFO:0000050 UBERON:0000033 ! part of head property_value: skos:prefLabel "head external integument structure" xsd:string [Term] id: UBERON:3000977 name: body external integument structure def: "Dermal, epidermal, glandular and pigment structures of the body integument." [AAO:EJS] is_a: UBERON:3000961 ! external integument structure intersection_of: UBERON:3000961 ! external integument structure intersection_of: BFO:0000050 UBERON:0002100 ! part of trunk relationship: BFO:0000050 UBERON:0002100 ! part of trunk property_value: skos:prefLabel "body external integument structure" xsd:string [Term] id: UBERON:3000981 name: limb external integument structure def: "Dermal, epidermal, glandular and pigment structures of the limb integument." [AAO:EJS] is_a: UBERON:3000961 ! external integument structure intersection_of: UBERON:3000961 ! external integument structure intersection_of: BFO:0000050 UBERON:0002101 ! part of limb relationship: BFO:0000050 UBERON:0002101 ! part of limb [Term] id: UBERON:3000982 name: tail external integument structure def: "Dermal, epidermal, glandular and pigment structures of the tail integument." [AAO:EJS] is_a: UBERON:3000961 ! external integument structure intersection_of: UBERON:3000961 ! external integument structure intersection_of: BFO:0000050 UBERON:0007812 ! part of post-anal tail relationship: BFO:0000050 UBERON:0007812 ! part of post-anal tail property_value: skos:prefLabel "tail external integument structure" xsd:string [Term] id: UBERON:3010200 name: vasculature of respiratory integument def: "Blood vessels in respiratory skin." [AAO:EJS] is_a: UBERON:0003504 ! respiratory system blood vessel intersection_of: UBERON:0001981 ! blood vessel intersection_of: BFO:0000050 UBERON:0001004 ! part of respiratory system intersection_of: BFO:0000050 UBERON:0002199 ! part of integument relationship: BFO:0000050 UBERON:0002199 ! part of integument property_value: IAO:0000116 "Modified from the original AAO source" xsd:string property_value: skos:prefLabel "vasculature of respiratory integument" xsd:string [Term] id: UBERON:3010706 name: lateral line nucleus is_a: UBERON:0000064 ! organ part relationship: BFO:0000050 UBERON:0002540 ! part of lateral line system [Term] id: UBERON:4000013 name: mineralized skeletal tissue def: "Skeletal tissue that is mineralized." [XAO:0004039, XAO:EJS] synonym: "mineralized tissue" BROAD [VSAO:0000013] xref: VSAO:0000013 xref: XAO:0004039 is_a: UBERON:0004755 ! skeletal tissue intersection_of: UBERON:0004755 ! skeletal tissue intersection_of: RO:0000086 PATO:0002444 ! has quality mineralized relationship: RO:0000086 PATO:0002444 ! has quality mineralized [Term] id: UBERON:4000020 name: mineralized extracellular matrix def: "Extracellular matrix that is mineralized." [PSPUB:0000170] is_a: GO:0031012 ! extracellular matrix is_a: UBERON:0000479 ! tissue [Term] id: UBERON:4000115 name: mineralized bone tissue def: "Bone tissue mineralized with hydroxyapatite." [PSPUB:0000170] is_a: UBERON:0002481 ! bone tissue is_a: UBERON:4000013 ! mineralized skeletal tissue intersection_of: UBERON:0002481 ! bone tissue intersection_of: RO:0000086 PATO:0002444 ! has quality mineralized relationship: BFO:0000051 CHEBI:52255 ! has part relationship: BFO:0000051 UBERON:4000020 ! has part mineralized extracellular matrix relationship: RO:0002202 UBERON:0008883 ! develops from osteoid [Term] id: UBERON:4000118 name: cellular bone tissue def: "Mineralized bone tissue that always includes non-terminally differentiated osteoblasts and osteocytes." [PSPUB:0000170] is_a: UBERON:4000115 ! mineralized bone tissue intersection_of: UBERON:4000115 ! mineralized bone tissue intersection_of: BFO:0000051 CL:0000137 ! has part osteocyte intersection_of: BFO:0000051 CL:0001040 ! has part non-terminally differentiated osteoblast relationship: BFO:0000051 CL:0000137 ! has part osteocyte relationship: BFO:0000051 CL:0001040 ! has part non-terminally differentiated osteoblast [Term] id: UBERON:4100000 name: skeletal element projection def: "Anatomical projection that is composed of bone or cartilage tissue." [PHENOSCAPE] is_a: UBERON:0004529 ! anatomical projection intersection_of: UBERON:0004529 ! anatomical projection intersection_of: BFO:0000050 UBERON:0004765 ! part of skeletal element relationship: BFO:0000050 UBERON:0004765 ! part of skeletal element [Term] id: UBERON:4200172 name: neck of humerus synonym: "anatomic neck of humerus" RELATED [FMA:23356] synonym: "collum anatomicum (Humerus)" EXACT [FMA:23356] synonym: "collum anatomicum humeri" EXACT OMO:0003011 [FMA:23356, FMA:TA] synonym: "humeral neck" EXACT [] xref: FMA:23356 xref: NCIT:C33164 is_a: UBERON:0005055 ! zone of long bone is_a: UBERON:0018664 ! neck of bone element intersection_of: UBERON:0001560 ! neck of organ intersection_of: BFO:0000050 UBERON:0000976 ! part of humerus relationship: BFO:0000050 UBERON:0004411 ! part of proximal epiphysis of humerus [Term] id: UBERON:4200230 name: surface of bone def: "An anatomical surface that is part of a bone." [PHENOSCAPE] synonym: "bone surface" EXACT [] is_a: BFO:0000004 is_a: UBERON:0006984 ! anatomical surface intersection_of: UBERON:0006984 ! anatomical surface intersection_of: BFO:0000050 UBERON:0001474 ! part of bone element relationship: BFO:0000050 UBERON:0001474 ! part of bone element property_value: skos:prefLabel "surface of bone" xsd:string [Term] id: UBERON:4300226 name: forelimb bud mesenchyme def: "Mesenchyme that is part of a forelimb bud." [PHENOSCAPE] is_a: UBERON:0003413 ! pectoral appendage bud mesenchyme is_a: UBERON:0010328 ! limb bud mesenchyme intersection_of: UBERON:0010328 ! limb bud mesenchyme intersection_of: BFO:0000050 UBERON:0005417 ! part of forelimb bud relationship: BFO:0000050 UBERON:0005417 ! part of forelimb bud property_value: terms:contributor https://orcid.org/0000-0003-3162-7490 [Term] id: UBERON:4300227 name: hindlimb bud mesenchyme def: "Mesenchyme that is part of a hindlimb bud." [PHENOSCAPE] is_a: UBERON:0003412 ! pelvic appendage bud mesenchyme is_a: UBERON:0010328 ! limb bud mesenchyme intersection_of: UBERON:0010328 ! limb bud mesenchyme intersection_of: BFO:0000050 UBERON:0005418 ! part of hindlimb bud relationship: BFO:0000050 UBERON:0005418 ! part of hindlimb bud property_value: terms:contributor https://orcid.org/0000-0003-3162-7490 [Term] id: UBERON:5001466 name: pedal digit plus metapodial segment def: "A subdivision of the autopod consisting of pedal digit plus the region incorporating a single metapodial element. These segments are typically repeated along the pre-axiom to post-axial axis." [http://orcid.org/0000-0002-6601-2165] synonym: "pedal digit" BROAD [http://orcid.org/0000-0002-6601-2165] synonym: "pedal digit ( phalanges plus metapodial) plus soft tissue" BROAD COMPARATIVE_PREFERRED [http://orcid.org/0000-0002-6601-2165] synonym: "pedal digit digitopodial subdivision" EXACT [http://orcid.org/0000-0002-6601-2165] synonym: "pedal digit ray" EXACT [http://orcid.org/0000-0002-6601-2165] is_a: UBERON:5002544 ! digit plus metapodial segment intersection_of: UBERON:5002544 ! digit plus metapodial segment intersection_of: BFO:0000050 UBERON:0002387 ! part of pes relationship: BFO:0000050 UBERON:0002387 ! part of pes relationship: BFO:0000051 UBERON:0001466 ! has part pedal digit relationship: RO:0002551 UBERON:5101466 ! has skeleton pedal digit digitopodial skeleton [Term] id: UBERON:5002389 name: manual digit plus metapodial segment def: "A subdivision of the autopod consisting of manual digit plus the region incorporating a single metapodial element. These segments are typically repeated along the pre-axiom to post-axial axis." [http://orcid.org/0000-0002-6601-2165] synonym: "manual digit" BROAD [http://orcid.org/0000-0002-6601-2165] synonym: "manual digit ( phalanges plus metapodial) plus soft tissue" BROAD COMPARATIVE_PREFERRED [http://orcid.org/0000-0002-6601-2165] synonym: "manual digit digitopodial subdivision" EXACT [http://orcid.org/0000-0002-6601-2165] synonym: "manual digit ray" EXACT [http://orcid.org/0000-0002-6601-2165] is_a: UBERON:5002544 ! digit plus metapodial segment intersection_of: UBERON:5002544 ! digit plus metapodial segment intersection_of: BFO:0000050 UBERON:0002102 ! part of forelimb relationship: BFO:0000050 UBERON:0002102 ! part of forelimb relationship: BFO:0000051 UBERON:0002389 ! has part manual digit relationship: RO:0002551 UBERON:5102389 ! has skeleton manual digit digitopodial skeleton [Term] id: UBERON:5002544 name: digit plus metapodial segment def: "A subdivision of the autopod consisting of digit plus the region incorporating a single metapodial element. These segments are typically repeated along the pre-axiom to post-axial axis." [http://orcid.org/0000-0002-6601-2165] synonym: "digit" BROAD [http://orcid.org/0000-0002-6601-2165] synonym: "digit ( phalanges plus metapodial) plus soft tissue" BROAD COMPARATIVE_PREFERRED [http://orcid.org/0000-0002-6601-2165] synonym: "digit digitopodial subdivision" EXACT [http://orcid.org/0000-0002-6601-2165] synonym: "digit ray" EXACT [http://orcid.org/0000-0002-6601-2165] is_a: BFO:0000002 is_a: UBERON:0000475 ! organism subdivision intersection_of: UBERON:0000475 ! organism subdivision intersection_of: RO:0002551 UBERON:5102544 ! has skeleton individual digit of digitopodial skeleton relationship: BFO:0000050 UBERON:0012140 ! part of digitopodium region relationship: BFO:0000051 UBERON:0002544 ! has part digit relationship: RO:0002551 UBERON:5102544 ! has skeleton individual digit of digitopodial skeleton [Term] id: UBERON:5101466 name: pedal digit digitopodial skeleton def: "A subdivision of the skeleton of the autopod consisting of the phalanges of pedal digit plus the associated metapodial element." [http://orcid.org/0000-0002-6601-2165] synonym: "pedal digit" RELATED COMPARATIVE_PREFERRED [http://orcid.org/0000-0002-6601-2165] synonym: "pedal digit skeleton" RELATED [http://orcid.org/0000-0002-6601-2165] is_a: UBERON:5102544 ! individual digit of digitopodial skeleton intersection_of: UBERON:0010912 ! subdivision of skeleton intersection_of: RO:0002576 UBERON:5001466 ! skeleton of pedal digit plus metapodial segment relationship: RO:0002576 UBERON:5001466 ! skeleton of pedal digit plus metapodial segment [Term] id: UBERON:5102389 name: manual digit digitopodial skeleton def: "A subdivision of the skeleton of the autopod consisting of the phalanges of manual digit plus the associated metapodial element." [http://orcid.org/0000-0002-6601-2165] synonym: "manual digit" RELATED COMPARATIVE_PREFERRED [http://orcid.org/0000-0002-6601-2165] synonym: "manual digit skeleton" RELATED [http://orcid.org/0000-0002-6601-2165] is_a: UBERON:5102544 ! individual digit of digitopodial skeleton intersection_of: UBERON:0010912 ! subdivision of skeleton intersection_of: RO:0002576 UBERON:5002389 ! skeleton of manual digit plus metapodial segment relationship: RO:0002576 UBERON:5002389 ! skeleton of manual digit plus metapodial segment [Term] id: UBERON:5102544 name: individual digit of digitopodial skeleton def: "A subdivision of the skeleton of the autopod consisting of the phalanges of a single digit plus the associated metapodial element." [http://orcid.org/0000-0002-6601-2165] synonym: "digit" RELATED COMPARATIVE_PREFERRED [http://orcid.org/0000-0002-6601-2165] synonym: "digit skeleton" RELATED [http://orcid.org/0000-0002-6601-2165] is_a: UBERON:0010712 ! limb skeleton subdivision intersection_of: UBERON:0010912 ! subdivision of skeleton intersection_of: RO:0002576 UBERON:5002544 ! skeleton of digit plus metapodial segment relationship: BFO:0000050 UBERON:0012150 ! part of skeleton of digitopodium relationship: RO:0002576 UBERON:5002544 ! skeleton of digit plus metapodial segment [Term] id: UBERON:6000002 name: arthropod tagma def: "One of the main divisions of the whole organism of arthropods formed from groups of segments." [doi:10.1016/B978-0-12-385026-3.00024-3] comment: Strictly speaking the term "tagma" cam be used for any metameric organism, however we follow the common usage which is to restrict the term to arthropods. xref: FBbt:00000002 {sssom:mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"} is_a: UBERON:0011676 ! subdivision of organism along main body axis relationship: RO:0002162 NCBITaxon:6656 ! in taxon Arthropoda property_value: RO:0002161 NCBITaxon:7742 [Term] id: UBERON:6000004 name: panarthropod head xref: FBbt:00000004 {sssom:mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"} is_a: UBERON:0000033 ! head intersection_of: UBERON:0000033 ! head intersection_of: BFO:0000050 NCBITaxon:88770 ! part of Panarthropoda relationship: BFO:0000050 NCBITaxon:88770 ! part of Panarthropoda [Term] id: UBERON:6000137 name: embryonic tagma def: "Any tagma (UBERON:6000002) that is part of some embryo (UBERON:6000052)." [FBC:auto_generated_definition] xref: FBbt:00000137 {sssom:mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"} is_a: UBERON:6000002 ! arthropod tagma intersection_of: UBERON:6000002 ! arthropod tagma intersection_of: BFO:0000050 UBERON:0000922 ! part of embryo relationship: BFO:0000050 UBERON:0000922 ! part of embryo [Term] id: UBERON:6001728 name: insect larval tagma def: "Any tagma (UBERON:6000002) that is part of some larva (UBERON:6001727)." [FBC:auto_generated_definition] xref: FBbt:00001728 {sssom:mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"} is_a: UBERON:6000002 ! arthropod tagma intersection_of: UBERON:6000002 ! arthropod tagma intersection_of: BFO:0000050 UBERON:0002548 ! part of larva relationship: BFO:0000050 UBERON:0002548 ! part of larva [Term] id: UBERON:6001730 name: insect larval head def: "Any head that is part of some larva." [FBC:auto_generated_definition] xref: FBbt:00001730 {sssom:mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"} is_a: UBERON:0000033 ! head intersection_of: UBERON:0000033 ! head intersection_of: BFO:0000050 UBERON:0002548 ! part of larva intersection_of: RO:0002162 NCBITaxon:50557 ! in taxon Insecta relationship: BFO:0000050 UBERON:0002548 ! part of larva relationship: RO:0002162 NCBITaxon:50557 ! in taxon Insecta [Term] id: UBERON:6002639 name: insect larval sense organ def: "Any sense organ that is part of some larva." [FBC:auto_generated_definition] synonym: "larval sense organ" EXACT [] xref: FBbt:00002639 {sssom:mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"} is_a: UBERON:0000020 ! sense organ intersection_of: UBERON:0000020 ! sense organ intersection_of: BFO:0000050 UBERON:0002548 ! part of larva intersection_of: RO:0002162 NCBITaxon:50557 ! in taxon Insecta relationship: BFO:0000050 UBERON:0002548 ! part of larva relationship: RO:0002162 NCBITaxon:50557 ! in taxon Insecta [Term] id: UBERON:6003005 name: insect adult tagma def: "Any tagma (UBERON:6000002) that is part of some adult (UBERON:6003004)." [FBC:auto_generated_definition] xref: FBbt:00003005 {sssom:mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"} is_a: UBERON:6000002 ! arthropod tagma intersection_of: UBERON:6000002 ! arthropod tagma intersection_of: BFO:0000050 UBERON:0007023 ! part of adult organism relationship: BFO:0000050 UBERON:0007023 ! part of adult organism [Term] id: UBERON:6003007 name: insect adult head def: "Head of the adult organism." [FBC:SPR] xref: FBbt:00003007 {sssom:mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"} is_a: UBERON:6000004 ! panarthropod head is_a: UBERON:6003005 ! insect adult tagma intersection_of: UBERON:0000033 ! head intersection_of: BFO:0000050 NCBITaxon:50557 ! part of Insecta intersection_of: BFO:0000050 UBERON:0007023 ! part of adult organism relationship: BFO:0000050 NCBITaxon:50557 ! part of Insecta [Term] id: UBERON:6007240 name: insect embryonic/larval sensillum def: "Any sensillum (UBERON:6007152) that is part of some larva (UBERON:6001727)." [FBC:auto_generated_definition] synonym: "larval sensillum" EXACT [] xref: FBbt:00007240 {sssom:mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"} is_a: UBERON:0002536 ! arthropod sensillum is_a: UBERON:6002639 ! insect larval sense organ intersection_of: UBERON:0002536 ! arthropod sensillum intersection_of: BFO:0000050 UBERON:0002548 ! part of larva [Term] id: UBERON:6007242 name: insect embryonic/larval head sensillum def: "Any sensillum (UBERON:6007152) that is part of some larval head (UBERON:6001730)." [FBC:auto_generated_definition] synonym: "larval head sensillum" NARROW [] xref: FBbt:00007242 {sssom:mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"} is_a: UBERON:0000963 ! head sensillum is_a: UBERON:6007240 ! insect embryonic/larval sensillum is_a: UBERON:6007280 ! insect embryonic/larval head sense organ intersection_of: UBERON:0002536 ! arthropod sensillum intersection_of: BFO:0000050 UBERON:6001730 ! part of insect larval head [Term] id: UBERON:6007280 name: insect embryonic/larval head sense organ def: "Any sense organ (UBERON:6005155) that is part of some larval head (UBERON:6001730)." [FBC:auto_generated_definition] synonym: "larval head sense organ" EXACT [] xref: FBbt:00007280 {sssom:mapping_justification="https://w3id.org/semapv/vocab/ManualMappingCuration"} is_a: UBERON:6002639 ! insect larval sense organ intersection_of: UBERON:0000020 ! sense organ intersection_of: BFO:0000050 UBERON:6001730 ! part of insect larval head relationship: BFO:0000050 UBERON:6001730 ! part of insect larval head [Term] id: UBERON:7500062 name: tibial tuberosity def: "The tibial tuberosity is on the anterior side of a tibia and is where a patella ligament attaches." [https://en.wikipedia.org/wiki/Tuberosity_of_the_tibia] synonym: "fossa digitalis" EXACT [] is_a: UBERON:0005813 ! tubercle is_a: UBERON:4100000 ! skeletal element projection intersection_of: UBERON:0005813 ! tubercle intersection_of: BFO:0000050 UBERON:0008772 ! part of proximal epiphysis of tibia relationship: BFO:0000050 UBERON:0008772 ! part of proximal epiphysis of tibia property_value: terms:contributor https://orcid.org/0000-0003-2699-3066 [Term] id: UBERON:7500107 name: sphenovomerine suture def: "A suture joining a sphenoid bone with the alae of a vomer to form a schindylesis type of joint." [DOI:10.1097/SCS.0000000000002945, PMID:27483100] is_a: UBERON:0009199 ! facial suture intersection_of: UBERON:0009199 ! facial suture intersection_of: RO:0002176 UBERON:0001677 ! connects sphenoid bone intersection_of: RO:0002176 UBERON:0002396 ! connects vomer relationship: RO:0002176 UBERON:0001677 ! connects sphenoid bone relationship: RO:0002176 UBERON:0002396 ! connects vomer property_value: skos:prefLabel "sphenovomerine suture" xsd:string property_value: terms:contributor https://orcid.org/0000-0001-8415-4848 property_value: terms:contributor https://orcid.org/0000-0003-2699-3066 [Term] id: UBERON:7770005 name: ascending colon epithelium def: "An epithelial layer that lines the ascending colon." [https://orcid.org/0000-0003-4389-9821] synonym: "ascending colon epithelial layer" EXACT [] synonym: "epithelial layer of ascending colon" EXACT [] synonym: "epithelial tissue of ascending colon" EXACT [] synonym: "epithelium of ascending colon" EXACT [] is_a: UBERON:0000397 ! colonic epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: BFO:0000050 UBERON:0001156 ! part of ascending colon relationship: BFO:0000050 UBERON:0001156 ! part of ascending colon property_value: terms:contributor https://orcid.org/0000-0002-7073-9172 property_value: terms:date "2025-05-27T17:07:22Z" xsd:dateTime [Term] id: UBERON:7770006 name: transverse colon epithelium def: "An epithelial layer that lines the transverse colon." [https://orcid.org/0000-0003-4389-9821] synonym: "epithelial layer of transverse colon" EXACT [] synonym: "epithelial tissue of transverse colon" EXACT [] synonym: "epithelium of transverse colon" EXACT [] synonym: "transverse colon epithelial layer" EXACT [] is_a: UBERON:0000397 ! colonic epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: BFO:0000050 UBERON:0001157 ! part of transverse colon relationship: BFO:0000050 UBERON:0001157 ! part of transverse colon property_value: terms:contributor https://orcid.org/0000-0002-7073-9172 property_value: terms:date "2025-05-27T17:07:22Z" xsd:dateTime [Term] id: UBERON:7770007 name: descending colon epithelium def: "An epithelial layer that lines the descending colon." [https://orcid.org/0000-0003-4389-9821] synonym: "descending colon epithelial layer" EXACT [] synonym: "epithelial layer of descending colon" EXACT [] synonym: "epithelial tissue of descending colon" EXACT [] synonym: "epithelium of descending colon" EXACT [] is_a: UBERON:0000397 ! colonic epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: BFO:0000050 UBERON:0001158 ! part of descending colon relationship: BFO:0000050 UBERON:0001158 ! part of descending colon property_value: terms:contributor https://orcid.org/0000-0002-7073-9172 property_value: terms:date "2025-05-27T17:07:22Z" xsd:dateTime [Term] id: UBERON:7770008 name: sigmoid colon epithelium def: "An epithelial layer that lines the sigmoid colon." [https://orcid.org/0000-0003-4389-9821] synonym: "epithelial layer of sigmoid colon" EXACT [] synonym: "epithelial tissue of sigmoid colon" EXACT [] synonym: "epithelium of sigmoid colon" EXACT [] synonym: "sigmoid colon epithelial layer" EXACT [] is_a: UBERON:0000397 ! colonic epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: BFO:0000050 UBERON:0001159 ! part of sigmoid colon relationship: BFO:0000050 UBERON:0001159 ! part of sigmoid colon property_value: skos:prefLabel "sigmoid colon epithelium" xsd:string property_value: terms:contributor https://orcid.org/0000-0002-7073-9172 property_value: terms:date "2025-05-27T17:07:22Z" xsd:dateTime [Term] id: UBERON:8000006 name: left side of back def: "Left part of the organism dorsal to a horizontal plane and bounded on one side by the same transverse plane." [https://microbiomedb.org/] is_a: UBERON:0001137 ! dorsum is_a: UBERON:0015212 ! lateral structure intersection_of: UBERON:0001137 ! dorsum intersection_of: BSPO:0000120 UBERON:0000468 ! multicellular organism relationship: BSPO:0000120 UBERON:0000468 ! multicellular organism property_value: skos:prefLabel "left side of back" xsd:string property_value: terms:contributor https://orcid.org/0000-0001-5208-3432 [Term] id: UBERON:8000007 name: right side of back def: "Right part of the organism dorsal to a horizontal plane and bounded on one side by the same transverse plane." [https://microbiomedb.org/] is_a: UBERON:0001137 ! dorsum is_a: UBERON:0015212 ! lateral structure intersection_of: UBERON:0001137 ! dorsum intersection_of: BSPO:0000121 UBERON:0000468 ! multicellular organism relationship: BSPO:0000121 UBERON:0000468 ! multicellular organism property_value: skos:prefLabel "right side of back" xsd:string property_value: terms:contributor https://orcid.org/0000-0001-5208-3432 [Term] id: UBERON:8000009 name: Purkinje fiber network def: "A collection of Purkinje fibers that receives signals from the right and left bundle branches and innervates the ventricular cardiac muscle. The Purkinje fiber network creates synchronized contractions of the heart ventricles." [PMID:26786210] synonym: "Purkinje fibre network" EXACT [PMID:26786210] is_a: UBERON:0010131 {source="https://github.com/obophenotype/uberon/issues/1785", source="https://orcid.org/0000-0001-5208-3432", source="https://orcid.org/0000-0002-9791-0064"} ! conducting tissue of heart is_a: UBERON:0018649 ! cardiac muscle tissue of ventricle relationship: BFO:0000050 UBERON:0004146 {source="https://github.com/obophenotype/uberon/issues/1785", source="https://orcid.org/0000-0001-5208-3432", source="https://orcid.org/0000-0002-9791-0064"} ! part of His-Purkinje system relationship: BFO:0000051 UBERON:0002354 {source="https://github.com/obophenotype/uberon/issues/1785", source="https://orcid.org/0000-0001-5208-3432", source="https://orcid.org/0000-0002-9791-0064"} ! has part cardiac Purkinje fiber property_value: terms:contributor https://orcid.org/0000-0001-5208-3432 [Term] id: UBERON:8300000 name: skin of scalp def: "A zone of skin that is part of a scalp." [http://www.ncbi.nlm.nih.gov/books/NBK551565/] synonym: "adult scalp zone of skin" EXACT [] synonym: "scalp skin" EXACT [] synonym: "scalp zone of skin" EXACT [] synonym: "zone of skin of adult scalp" EXACT [] synonym: "zone of skin of scalp" EXACT [] xref: FMA:24757 is_a: UBERON:0001084 ! skin of head intersection_of: UBERON:0000014 ! zone of skin intersection_of: BFO:0000050 UBERON:0000403 ! part of scalp relationship: BFO:0000050 UBERON:0000403 ! part of scalp property_value: terms:contributor https://orcid.org/0000-0001-9897-3238 [Term] id: UBERON:8300001 name: right forelimb def: "A forelimb that is on the right side of a pectoral complex." [UBERONREF:0000003] xref: FMA:7185 is_a: UBERON:0002102 ! forelimb is_a: UBERON:0015212 ! lateral structure intersection_of: UBERON:0002102 ! forelimb intersection_of: BSPO:0000121 UBERON:0010708 ! pectoral complex relationship: BSPO:0000121 UBERON:0010708 ! pectoral complex property_value: terms:contributor https://orcid.org/0000-0001-9897-3238 [Term] id: UBERON:8300002 name: left forelimb def: "A forelimb that is on the left side of a pectoral complex." [UBERONREF:0000003] xref: FMA:7186 is_a: UBERON:0002102 ! forelimb is_a: UBERON:0015212 ! lateral structure intersection_of: UBERON:0002102 ! forelimb intersection_of: BSPO:0000120 UBERON:0010708 ! pectoral complex relationship: BSPO:0000120 UBERON:0010708 ! pectoral complex property_value: terms:contributor https://orcid.org/0000-0001-9897-3238 [Term] id: UBERON:8300003 name: right hindlimb def: "A hindlimb that is on the right side of a pelvic complex." [UBERONREF:0000003] xref: FMA:7187 is_a: UBERON:0002103 ! hindlimb is_a: UBERON:0015212 ! lateral structure intersection_of: UBERON:0002103 ! hindlimb intersection_of: BSPO:0000121 UBERON:0010709 ! pelvic complex relationship: BSPO:0000121 UBERON:0010709 ! pelvic complex property_value: terms:contributor https://orcid.org/0000-0001-9897-3238 [Term] id: UBERON:8300004 name: left hindlimb def: "A hindlimb that is on the left side of a pelvic complex." [UBERONREF:0000003] xref: FMA:7188 is_a: UBERON:0002103 ! hindlimb is_a: UBERON:0015212 ! lateral structure intersection_of: UBERON:0002103 ! hindlimb intersection_of: BSPO:0000120 UBERON:0010709 ! pelvic complex relationship: BSPO:0000120 UBERON:0010709 ! pelvic complex property_value: terms:contributor https://orcid.org/0000-0001-9897-3238 [Term] id: UBERON:8400001 name: hepatic acinus zone 1 def: "The region of the hepatic acinus that is closest to the arterial blood supply and has the highest oxygen concentration. Zone 1 is located in the periportal region of the liver lobule, closest to the portal triad. Hepatocytes in this region are primarily involved in oxidative energy metabolism." [PMID:29763190] synonym: "hepatic acinus periportal zone" EXACT [PMID:28126520] is_a: UBERON:8400005 ! metabolic zone of liver relationship: BFO:0000050 UBERON:0001172 ! part of hepatic acinus relationship: RO:0002131 UBERON:8400006 {xref="PMID:28126520"} ! overlaps liver lobule periportal region property_value: RO:0002175 NCBITaxon:40674 property_value: terms:contributor https://orcid.org/0000-0003-2034-601X creation_date: 2020-09-08T14:14:21Z [Term] id: UBERON:8400002 name: hepatic acinus zone 3 def: "The region of the hepatic acinus immediately surrounding the central veins. This region has the lowest oxygen concentration in the acinus. Zone 3 is located in the centrilobular region of the liver lobule, closest to the central vein. Hepatocytes in this region are the primary location for the biotransformation of drugs." [PMID:29763190] synonym: "hepatic acinus centrilobular zone" EXACT [PMID:28126520] synonym: "hepatic acinus pericentral zone" EXACT [PMID:28126520] synonym: "hepatic acinus perivenous zone" EXACT [PMID:28126520] is_a: UBERON:8400005 ! metabolic zone of liver relationship: BFO:0000050 UBERON:0001172 ! part of hepatic acinus relationship: RO:0002131 UBERON:8400007 {xref="PMID:28126520"} ! overlaps liver lobule centrilobular region property_value: RO:0002175 NCBITaxon:40674 property_value: terms:contributor https://orcid.org/0000-0003-2034-601X creation_date: 2020-09-08T15:05:03Z [Term] id: UBERON:8400003 name: hepatic acinus zone 2 def: "The region of the hepatic acinus in between zones 1 and 3. Blood in this region has an intermediate oxygen concentration relative to the other two zones of the hepatic acinus. Zone 2 is located in the midzonal region of the liver lobule. Hepatocytes in this region have mixed functionality in comparison with those in zones 1 and 3." [PMID:29763190] synonym: "hepatic acinus intermediary zone" EXACT [PMID:28126520] is_a: UBERON:8400005 ! metabolic zone of liver relationship: BFO:0000050 UBERON:0001172 ! part of hepatic acinus relationship: RO:0002131 UBERON:8400008 {xref="PMID:28126520"} ! overlaps liver lobule midzonal region relationship: RO:0002220 UBERON:8400001 ! adjacent to hepatic acinus zone 1 relationship: RO:0002220 UBERON:8400002 ! adjacent to hepatic acinus zone 3 property_value: RO:0002175 NCBITaxon:40674 property_value: terms:contributor https://orcid.org/0000-0003-2034-601X creation_date: 2020-09-08T15:15:57Z [Term] id: UBERON:8400005 name: metabolic zone of liver def: "Any of the metabolic zones found in the liver. Liver tissue is heterogenous at the level of morphometry and histochemistry. This heterogeneity is linked to the position of a cell within the functional unit of the tissue, which, in turn, is related to the blood supply: cells located in the upstream zone differ from those in the downstream zone with respect to subcellular structures, key enzymes, translocators, and receptors and, therefore, have different metabolic capacities. This is the basis for 'metabolic zonation', a concept first proposed in mammals for carbohydrate metabolism and later expanded to include amino acid and ammonia metabolism, xenobiotic metabolism, protective metabolism, and formation of plasma proteins." [DOI:10.1016/S0968-0004(78)91764-4, PMID:8839925] synonym: "hepatic acinus metabolic zone" EXACT [PMID:8839925] is_a: UBERON:0000063 ! organ subunit relationship: BFO:0000050 UBERON:0002107 ! part of liver property_value: RO:0002175 NCBITaxon:40674 property_value: terms:contributor https://orcid.org/0000-0003-2034-601X creation_date: 2020-09-29T15:45:36Z [Term] id: UBERON:8400006 name: liver lobule periportal region def: "The region of the liver lobule that is closest to the portal triad. The functionally-defined hepatic acinus zone 1 is generally found in this region." [PMID:28126520] synonym: "hepatic acinus zone 1" RELATED [PMID:28126520] is_a: UBERON:8400005 ! metabolic zone of liver relationship: BFO:0000050 UBERON:0004647 ! part of liver lobule relationship: RO:0002131 UBERON:8400001 {xref="PMID:28126520"} ! overlaps hepatic acinus zone 1 relationship: RO:0002220 UBERON:0001279 ! adjacent to portal triad property_value: RO:0002175 NCBITaxon:40674 property_value: terms:contributor https://orcid.org/0000-0003-2034-601X creation_date: 2020-10-05T12:56:57Z [Term] id: UBERON:8400007 name: liver lobule centrilobular region def: "The region of the liver lobule that is closest to the central vein. The functionally-defined hepatic acinus zone 3 is generally found in this region." [PMID:28126520] synonym: "hepatic acinus zone 3" RELATED [PMID:28126520] is_a: UBERON:8400005 ! metabolic zone of liver relationship: BFO:0000050 UBERON:0004647 ! part of liver lobule relationship: RO:0002131 UBERON:8400002 {xref="PMID:28126520"} ! overlaps hepatic acinus zone 3 relationship: RO:0002220 UBERON:0006841 ! adjacent to central vein of liver property_value: RO:0002175 NCBITaxon:40674 property_value: terms:contributor https://orcid.org/0000-0003-2034-601X creation_date: 2020-10-05T15:43:18Z [Term] id: UBERON:8400008 name: liver lobule midzonal region def: "The region of the liver lobule that is between the periportal and centrilobular regions. The functionally-defined hepatic acinus zone 2 is generally found in this region." [PMID:28126520] synonym: "hepatic acinus zone 2" RELATED [PMID:28126520] is_a: UBERON:8400005 ! metabolic zone of liver relationship: BFO:0000050 UBERON:0004647 ! part of liver lobule relationship: RO:0002131 UBERON:8400003 {xref="PMID:28126520"} ! overlaps hepatic acinus zone 2 relationship: RO:0002220 UBERON:0001279 ! adjacent to portal triad relationship: RO:0002220 UBERON:0006841 ! adjacent to central vein of liver property_value: RO:0002175 NCBITaxon:40674 property_value: terms:contributor https://orcid.org/0000-0003-2034-601X creation_date: 2020-10-05T15:52:22Z [Term] id: UBERON:8400021 name: liver serosa def: "Hepatic serous coat; peritoneal covering of the liver, enclosing almost all except for a triangular area on its posterior surface (the 'bare area of the liver') and a smaller area where the liver and gallbladder are in direct contact." [https://medical-dictionary.thefreedictionary.com/serosa+of+liver, https://orcid.org/0000-0002-0449-2730] synonym: "serosa of liver" EXACT [FMA:15811] synonym: "tunica serosa hepatis" EXACT OMO:0003011 [https://medical-dictionary.thefreedictionary.com/serosa+of+liver] is_a: UBERON:0000042 ! serous membrane intersection_of: UBERON:0000042 ! serous membrane intersection_of: BFO:0000050 UBERON:0002107 ! part of liver relationship: BFO:0000050 UBERON:0002107 ! part of liver property_value: skos:prefLabel "liver serosa" xsd:string property_value: terms:contributor https://orcid.org/0000-0003-2034-601X [Term] id: UBERON:8400023 name: liver subserosa def: "Subserosal tissue of liver. A zone of areolar connective tissue lying beneath the serous coat of the liver and distinguished with difficulty from the fibrous capsule of Glisson." [FMA:15812, https://medical-dictionary.thefreedictionary.com/subserosa+of+liver, https://orcid.org/0000-0002-0449-2730] synonym: "hepatic subserosa" EXACT [] synonym: "subserosal tissue of liver" EXACT [] synonym: "subserous layer of liver" EXACT [] synonym: "tela subserosa (hepar)" EXACT [FMA:15821] synonym: "tela subserosa hepatis" EXACT [https://medical-dictionary.thefreedictionary.com/subserosa+of+liver] is_a: UBERON:0012375 ! subserosa intersection_of: UBERON:0012375 ! subserosa intersection_of: BFO:0000050 UBERON:0002107 ! part of liver relationship: BFO:0000050 UBERON:0002107 ! part of liver property_value: skos:prefLabel "liver subserosa" xsd:string property_value: terms:contributor https://orcid.org/0000-0003-2034-601X [Term] id: UBERON:8400024 name: subcapsular region of liver def: "Region of liver parenchyma immediately below the capsule. This region is frequently specified in pathology diagnoses." [https://orcid.org/0000-0002-0449-2730, PMID:30992875] synonym: "liver subcapsular region" EXACT [PMID:30992875] synonym: "liver subcapsular tissue" EXACT [PMID:30992875] synonym: "subcapsular tissue of liver" EXACT [PMID:30992875] is_a: UBERON:0001280 ! liver parenchyma intersection_of: UBERON:0000353 ! parenchyma intersection_of: BFO:0000050 UBERON:0002107 ! part of liver intersection_of: RO:0002220 UBERON:0016479 ! adjacent to capsule of liver relationship: RO:0002220 UBERON:0016479 ! adjacent to capsule of liver property_value: terms:contributor https://orcid.org/0000-0003-2034-601X [Term] id: UBERON:8410000 name: duodeno-jejunal junction def: "The anatomical junction between the duodenum and the jejunum." [PMID:23961897, PMID:29064554] subset: human_reference_atlas synonym: "duodeno-jejunal flexure" EXACT [] synonym: "duodenojejunal flexure" EXACT [] synonym: "duodenojejunal junction" EXACT [] synonym: "flexura duodenojejunalis" EXACT OMO:0003011 [Wikipedia:Duodenojejunal_flexure] xref: FMA:15957 xref: https://orcid.org/0000-0003-4183-8865 xref: TA2:2952 xref: WikipediaVersioned:Duodenojejunal_flexure&oldid=937307798 is_a: UBERON:8410024 ! intestinal junction intersection_of: UBERON:0007651 ! anatomical junction intersection_of: RO:0002176 UBERON:0002114 ! connects duodenum intersection_of: RO:0002176 UBERON:0002115 ! connects jejunum relationship: BFO:0000050 UBERON:0002108 ! part of small intestine relationship: RO:0002176 UBERON:0002114 ! connects duodenum relationship: RO:0002176 UBERON:0002115 ! connects jejunum property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:8410001 name: small intestine venule def: "Venule of villus of small intestine." [https://orcid.org/0000-0003-4183-8865] subset: location_grouping synonym: "venule of small intestine" EXACT [] is_a: UBERON:0001979 ! venule intersection_of: UBERON:0001979 ! venule intersection_of: BFO:0000050 UBERON:0001213 ! part of intestinal villus relationship: BFO:0000050 UBERON:0001213 ! part of intestinal villus property_value: skos:prefLabel "small intestine venule" xsd:string property_value: terms:contributor https://orcid.org/0000-0002-2825-0621 [Term] id: UBERON:8410002 name: small intestine lymphatic vessel def: "A lymphatic vessel that supplies the small intestine." [http://orcid.org/0000-0003-4183-8865] subset: location_grouping synonym: "lymphatic vessel of small intestine" EXACT [] is_a: UBERON:0001473 ! lymphatic vessel intersection_of: UBERON:0001473 ! lymphatic vessel intersection_of: BFO:0000050 UBERON:0002108 ! part of small intestine relationship: BFO:0000050 UBERON:0002108 ! part of small intestine property_value: terms:contributor https://orcid.org/0000-0002-2825-0621 [Term] id: UBERON:8410003 name: ductal plate def: "In human, ductal plate is a double-layered cylindrical structure of bile duct epithelium that surrounds the portal ramifications by the eighth gestational week. After approximately the 12th gestational week, remodelling of ductal plate begins, and maturity is attained by the end of gestation or early postnatal period." [http://orcid.org/0000-0002-7073-9172, PMID:28515578] subset: added_for_HCA is_a: BFO:0000002 is_a: UBERON:0010000 ! multicellular anatomical structure relationship: BFO:0000050 UBERON:0002394 ! part of bile duct relationship: BFO:0000051 UBERON:0004820 ! has part bile duct epithelium relationship: RO:0002221 UBERON:0002017 ! surrounds portal vein relationship: RO:0002488 UBERON:0000068 ! existence starts during embryo stage relationship: RO:0002492 UBERON:0007220 ! existence ends during late embryonic stage property_value: RO:0002175 NCBITaxon:40674 property_value: terms:contributor https://orcid.org/0000-0002-2825-0621 [Term] id: UBERON:8410004 name: small intestine arteriole def: "Arteriole of villus of small intestine." [http://orcid.org/0000-0003-4183-8865] subset: location_grouping synonym: "arteriole of small intestine" EXACT [] synonym: "arteriole of villus of small intestine" EXACT [] synonym: "small intestine villus arteriole" EXACT [] is_a: UBERON:0001980 ! arteriole intersection_of: UBERON:0001980 ! arteriole intersection_of: BFO:0000050 UBERON:0001213 ! part of intestinal villus relationship: BFO:0000050 UBERON:0001213 ! part of intestinal villus property_value: skos:prefLabel "small intestine arteriole" xsd:string property_value: terms:contributor https://orcid.org/0000-0002-2825-0621 [Term] id: UBERON:8410007 name: myenteric nerve plexus of anorectum def: "Myenteric nerve plexus that is located in the anorectum." [http://orcid.org/0000-0003-3440-1876] synonym: "anorectum myenteric nerve plexus" EXACT [] is_a: UBERON:0002439 ! myenteric nerve plexus intersection_of: UBERON:0002439 ! myenteric nerve plexus intersection_of: BFO:0000050 UBERON:8410050 ! part of anorectum relationship: BFO:0000050 UBERON:8410050 ! part of anorectum property_value: terms:contributor https://orcid.org/0000-0002-2825-0621 [Term] id: UBERON:8410008 name: venule of anorectum def: "A venule that is located in the anorectum." [http://orcid.org/0000-0003-3440-1876] synonym: "anorectum venule" EXACT [] is_a: UBERON:0001979 ! venule intersection_of: UBERON:0001979 ! venule intersection_of: BFO:0000050 UBERON:8410050 ! part of anorectum relationship: BFO:0000050 UBERON:8410050 ! part of anorectum property_value: skos:prefLabel "venule of anorectum" xsd:string property_value: terms:contributor https://orcid.org/0000-0002-2825-0621 [Term] id: UBERON:8410009 name: arteriole of anorectum def: "An arteriole that is located in the anorectum." [http://orcid.org/0000-0003-3440-1876] synonym: "anorectum arteriole" EXACT [] is_a: UBERON:0001980 ! arteriole intersection_of: UBERON:0001980 ! arteriole intersection_of: BFO:0000050 UBERON:8410050 ! part of anorectum relationship: BFO:0000050 UBERON:8410050 ! part of anorectum property_value: skos:prefLabel "arteriole of anorectum" xsd:string property_value: terms:contributor https://orcid.org/0000-0002-2825-0621 [Term] id: UBERON:8410011 name: myenteric nerve plexus of appendix def: "Myenteric nerve plexus that is located in the vermiform appendix." [http://orcid.org/0000-0003-3440-1876] synonym: "myenteric nerve plexus of appendix vermiformis" EXACT [] synonym: "myenteric nerve plexus of vermiform appendix" EXACT [] is_a: UBERON:0002439 ! myenteric nerve plexus intersection_of: UBERON:0002439 ! myenteric nerve plexus intersection_of: BFO:0000050 UBERON:0001154 ! part of vermiform appendix relationship: BFO:0000050 UBERON:0001154 ! part of vermiform appendix property_value: terms:contributor https://orcid.org/0000-0002-2825-0621 [Term] id: UBERON:8410015 name: arteriole of colon def: "An arteriole located in the colon." [http://orcid.org/0000-0003-3440-1876, http://orcid.org/0000-0003-4183-8865] is_a: UBERON:0001980 ! arteriole intersection_of: UBERON:0001980 ! arteriole intersection_of: BFO:0000050 UBERON:0001155 ! part of colon relationship: BFO:0000050 UBERON:0001155 ! part of colon property_value: skos:prefLabel "arteriole of colon" xsd:string property_value: terms:contributor https://orcid.org/0000-0002-2825-0621 [Term] id: UBERON:8410016 name: descending sigmoid junction def: "The anatomical junction between the descending colon and the sigmoid colon." [https://orcid.org/0000-0003-4183-8865, PMID:27233374] synonym: "descending-sigmoid colon junction" EXACT [] synonym: "descending-sigmoid junction" EXACT [] synonym: "sigmoid junction" BROAD [] is_a: UBERON:8410024 ! intestinal junction intersection_of: UBERON:0007651 ! anatomical junction intersection_of: RO:0002176 UBERON:0001158 ! connects descending colon intersection_of: RO:0002176 UBERON:0001159 ! connects sigmoid colon relationship: BFO:0000050 UBERON:0000168 ! part of proximal-distal subdivision of colon relationship: RO:0002176 UBERON:0001158 ! connects descending colon relationship: RO:0002176 UBERON:0001159 ! connects sigmoid colon property_value: terms:contributor https://orcid.org/0000-0002-2825-0621 [Term] id: UBERON:8410017 name: left colic vein def: "A portal vein that drains the descending colon. It is a tributary of the inferior mesenteric vein, and follows the path of its corresponding artery, the left colic artery." [https://orcid.org/0000-0003-4183-8865, WikipediaVersioned:Left_colic_vein&oldid=964575339] subset: human_reference_atlas xref: FMA:15394 is_a: UBERON:0002017 ! portal vein intersection_of: UBERON:0002017 ! portal vein intersection_of: RO:0002376 UBERON:0001215 ! tributary of inferior mesenteric vein intersection_of: RO:0020102 UBERON:0001158 ! vessel drains blood from descending colon relationship: RO:0002376 UBERON:0001215 ! tributary of inferior mesenteric vein relationship: RO:0020102 UBERON:0001158 ! vessel drains blood from descending colon property_value: RO:0002175 NCBITaxon:9606 property_value: terms:contributor https://orcid.org/0000-0002-2825-0621 [Term] id: UBERON:8410018 name: right colic vein def: "A portal vein that drains the ascending colon. It is a tributary of the superior mesenteric vein, and travels with its corresponding artery, the right colic artery." [https://orcid.org/0000-0003-4183-8865, WikipediaVersioned:Right_colic_vein&oldid=870898828] subset: human_reference_atlas xref: FMA:15407 is_a: UBERON:0002017 ! portal vein intersection_of: UBERON:0002017 ! portal vein intersection_of: RO:0002376 UBERON:0001138 ! tributary of superior mesenteric vein intersection_of: RO:0020102 UBERON:0001156 ! vessel drains blood from ascending colon relationship: RO:0002376 UBERON:0001138 ! tributary of superior mesenteric vein relationship: RO:0020102 UBERON:0001156 ! vessel drains blood from ascending colon property_value: RO:0002175 NCBITaxon:9606 property_value: terms:contributor https://orcid.org/0000-0002-2825-0621 [Term] id: UBERON:8410019 name: jejuno-ileal junction def: "The area where the jejunum ends and the ileum part of the intestine begins. Although there is no clear distinct section, the ileum is narrower and has smaller villi than the jejunum." [DOI:10.1016/B978-1-4377-2206-2.00068-3, https://orcid.org/0000-0003-4183-8865, PMID:21802415] synonym: "jejunoileal junction" EXACT [] is_a: UBERON:8410024 ! intestinal junction intersection_of: UBERON:0007651 ! anatomical junction intersection_of: RO:0002176 UBERON:0002115 ! connects jejunum intersection_of: RO:0002176 UBERON:0002116 ! connects ileum relationship: BFO:0000050 UBERON:0002108 ! part of small intestine relationship: RO:0002176 UBERON:0002115 ! connects jejunum relationship: RO:0002176 UBERON:0002116 ! connects ileum property_value: terms:contributor https://orcid.org/0000-0002-2825-0621 [Term] id: UBERON:8410020 name: venule of appendix def: "A venule located in the vermiform appendix." [http://orcid.org/0000-0003-3440-1876] synonym: "venule of vermiform appendix" EXACT [] synonym: "vermiform appendix venule" EXACT [] is_a: UBERON:0001979 ! venule intersection_of: UBERON:0001979 ! venule intersection_of: BFO:0000050 UBERON:0001154 ! part of vermiform appendix relationship: BFO:0000050 UBERON:0001154 ! part of vermiform appendix property_value: terms:contributor https://orcid.org/0000-0002-2825-0621 [Term] id: UBERON:8410024 name: intestinal junction def: "An anatomical junction between two parts of the intestine." [https://orcid.org/0000-0002-7073-9172] synonym: "junction of intestine" EXACT [] is_a: UBERON:1100000 ! digestive tract junction intersection_of: UBERON:0007651 ! anatomical junction intersection_of: BFO:0000050 UBERON:0000160 ! part of intestine intersection_of: RO:0002176 UBERON:0004921 ! connects subdivision of digestive tract relationship: BFO:0000050 UBERON:0000160 ! part of intestine property_value: skos:prefLabel "intestinal junction" xsd:string property_value: terms:contributor https://orcid.org/0000-0002-2825-0621 [Term] id: UBERON:8410028 name: arteriole of appendix def: "An arteriole located in the vermiform appendix." [http://orcid.org/0000-0003-3440-1876] synonym: "appendix vermiformis arteriole" EXACT [] synonym: "arteriole of appendix vermiformis" EXACT [] synonym: "arteriole of vermiform appendix" EXACT [] synonym: "vermiform appendix arteriole" EXACT [] is_a: UBERON:0001980 ! arteriole intersection_of: UBERON:0001980 ! arteriole intersection_of: BFO:0000050 UBERON:0001154 ! part of vermiform appendix relationship: BFO:0000050 UBERON:0001154 ! part of vermiform appendix property_value: terms:contributor https://orcid.org/0000-0002-2825-0621 [Term] id: UBERON:8410030 name: lymphatic vessel of appendix def: "A lymphatic vessel located in the vermiform appendix." [http://orcid.org/0000-0003-3440-1876] synonym: "lymphatic vessel of appendix vermiformis" EXACT [] synonym: "lymphatic vessel of vermiform appendix" EXACT [] is_a: UBERON:0001473 ! lymphatic vessel intersection_of: UBERON:0001473 ! lymphatic vessel intersection_of: BFO:0000050 UBERON:0001154 ! part of vermiform appendix relationship: BFO:0000050 UBERON:0001154 ! part of vermiform appendix property_value: terms:contributor https://orcid.org/0000-0002-2825-0621 [Term] id: UBERON:8410031 name: muscularis mucosae of appendix def: "A muscularis mucosa that is part of a vermiform appendix." [http://orcid.org/0000-0003-3440-1876] synonym: "muscularis mucosae of appendix vermiformis" EXACT [] synonym: "muscularis mucosae of vermiform appendix" EXACT [] is_a: UBERON:0001239 ! muscularis mucosae of large intestine intersection_of: UBERON:0006676 ! muscularis mucosa intersection_of: BFO:0000050 UBERON:0001154 ! part of vermiform appendix relationship: BFO:0000050 UBERON:0001154 ! part of vermiform appendix property_value: terms:contributor https://orcid.org/0000-0002-2825-0621 [Term] id: UBERON:8410032 name: trabecular sinus of lymph node def: "The trabecular sinus is the lymph-filled space outside the trabeculae between lobules of the lymph node. This is a continuation of the subcapsular sinus which receives the afferent vessels and is present beneath the capsule. This space is traversed by both reticular fibers and cells in the lymph." [http://orcid.org/0000-0003-4183-8865, PMID:32491649, WikipediaVersioned:Lymph_node&oldid=1020495758] subset: human_reference_atlas synonym: "lymph node trabecular sinus" EXACT [] is_a: UBERON:0000464 ! anatomical space intersection_of: UBERON:0000464 ! anatomical space intersection_of: BFO:0000050 UBERON:0000029 ! part of lymph node intersection_of: RO:0002220 UBERON:0002195 ! adjacent to trabecula of lymph node relationship: BFO:0000050 UBERON:0000029 ! part of lymph node relationship: RO:0002220 UBERON:0002195 ! adjacent to trabecula of lymph node property_value: RO:0002175 NCBITaxon:9606 property_value: terms:contributor https://orcid.org/0000-0002-2825-0621 [Term] id: UBERON:8410033 name: lymph node vein def: "A vein where lymph node venules condense and which exits at the lymph node hilum. It is also called hilar vein." [http://orcid.org/0000-0003-3440-1876, PMID:17067937, WikipediaVersioned:Lymph_node&oldid=1001655735#Structure] subset: human_reference_atlas synonym: "hilar vein of lymph node" EXACT [] synonym: "vein of lymph node" EXACT [] is_a: UBERON:0001638 ! vein intersection_of: UBERON:0001638 ! vein intersection_of: RO:0020102 UBERON:0000029 ! vessel drains blood from lymph node relationship: RO:0020102 UBERON:0000029 ! vessel drains blood from lymph node property_value: RO:0002175 NCBITaxon:9606 property_value: terms:contributor https://orcid.org/0000-0002-2825-0621 [Term] id: UBERON:8410034 name: lymph node artery def: "An artery that enters the lymph node at the hilum and branches into smaller arterioles." [http://orcid.org/0000-0003-3440-1876, PMID:17067937, WikipediaVersioned:Lymph_node&oldid=1001655735#Structure] subset: human_reference_atlas synonym: "artery of lymph node" EXACT [] synonym: "hilar artery of lymph node" EXACT [] is_a: UBERON:0001637 ! artery intersection_of: UBERON:0001637 ! artery intersection_of: RO:0020101 UBERON:0000029 ! vessel supplies blood to lymph node relationship: RO:0020101 UBERON:0000029 ! vessel supplies blood to lymph node property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:8410035 name: medullary arteriole of lymph node def: "An arteriole that arises from the hilar artery of a lymph node and radiates centrifugally, branching in the medulla." [http://orcid.org/0000-0003-3440-1876, PMID:17067937] subset: human_reference_atlas synonym: "arteriole of medulla of lymph node" EXACT [] is_a: UBERON:8410042 ! arteriole of lymph node intersection_of: UBERON:0001980 ! arteriole intersection_of: BFO:0000050 UBERON:0002007 ! part of medulla of lymph node relationship: BFO:0000050 UBERON:0002007 ! part of medulla of lymph node relationship: RO:0002252 UBERON:8410034 ! connecting branch of lymph node artery property_value: RO:0002175 NCBITaxon:9606 property_value: terms:contributor https://orcid.org/0000-0002-2825-0621 [Term] id: UBERON:8410036 name: medullary venule of lymph node def: "Medullary venules are a continuation of high endothelial venules which condense repeatedly in the interfollicular cortex and peripheral deep cortical unit and then transition to medullary venules at the corticomedullary junction. The medullary venules condense and return centripetally to the hilar vein." [http://orcid.org/0000-0003-3440-1876, PMID:17067937] subset: human_reference_atlas synonym: "venule of medulla of lymph node" EXACT [] is_a: UBERON:8410041 ! venule of lymph node intersection_of: UBERON:0001979 ! venule intersection_of: BFO:0000050 UBERON:0002007 ! part of medulla of lymph node relationship: BFO:0000050 UBERON:0002007 ! part of medulla of lymph node property_value: RO:0002175 NCBITaxon:9606 property_value: terms:contributor https://orcid.org/0000-0002-2825-0621 [Term] id: UBERON:8410037 name: high endothelial venule def: "High endothelial venules are specialized blood vessels adapted for lymphocyte trafficking. They form a spatially organized network, which controls both the type of lymphocyte and the site of entry into lymphoid tissues. Uniquely, high endothelial venules express vascular addressins that regulate lymphocyte entry into lymphoid organs. They perform this function in all lymphoid organs except the spleen." [http://orcid.org/0000-0003-3440-1876, PMID:28217126] synonym: "HEV" BROAD OMO:0003000 [] xref: BTO:0004528 xref: NCIT:C32739 is_a: UBERON:0035428 ! postcapillary venule property_value: terms:contributor https://orcid.org/0000-0002-2825-0621 [Term] id: UBERON:8410038 name: high endothelial venule of lymph node def: "A high endothelial venule that is part of a of lymph node." [http://orcid.org/0000-0003-3440-1876, PMID:28217126] subset: human_reference_atlas synonym: "lymph node high endothelial venule" EXACT [] is_a: UBERON:8410037 ! high endothelial venule is_a: UBERON:8410041 ! venule of lymph node intersection_of: UBERON:8410037 ! high endothelial venule intersection_of: BFO:0000050 UBERON:0000029 ! part of lymph node property_value: RO:0002175 NCBITaxon:9606 property_value: terms:contributor https://orcid.org/0000-0002-2825-0621 [Term] id: UBERON:8410039 name: high endothelial venule of appendix def: "A high endothelial venule that is located in the vermiform appendix." [http://orcid.org/0000-0003-3440-1876, PMID:28217126] synonym: "appendix high endothelial venule" EXACT [] synonym: "high endothelial venule of appendix vermiformis" EXACT [] synonym: "high endothelial venule of vermiform appendix" EXACT [] is_a: UBERON:8410020 ! venule of appendix is_a: UBERON:8410037 ! high endothelial venule intersection_of: UBERON:8410037 ! high endothelial venule intersection_of: BFO:0000050 UBERON:0001154 ! part of vermiform appendix property_value: terms:contributor https://orcid.org/0000-0002-2825-0621 [Term] id: UBERON:8410040 name: high endothelial venule of small intestine Peyer's patch def: "A high endothelial venule that is located in a Peyer's patch in the small intestine." [http://orcid.org/0000-0003-3440-1876, http://orcid.org/0000-0003-4183-8865, PMID:20800822, PMID:28217126] synonym: "high endothelial venule of Peyer's patch" BROAD [] synonym: "high endothelial venule of Peyer's patch of small intestine" EXACT [] is_a: UBERON:8410037 ! high endothelial venule intersection_of: UBERON:8410037 ! high endothelial venule intersection_of: BFO:0000050 UBERON:0003454 ! part of small intestine Peyer's patch relationship: BFO:0000050 UBERON:0003454 ! part of small intestine Peyer's patch property_value: terms:contributor https://orcid.org/0000-0002-2825-0621 [Term] id: UBERON:8410041 name: venule of lymph node def: "A venule that is part of a lymph node." [http://orcid.org/0000-0003-3440-1876, PMID:17067937] subset: human_reference_atlas synonym: "lymph node venule" EXACT [] is_a: UBERON:0001979 ! venule intersection_of: UBERON:0001979 ! venule intersection_of: BFO:0000050 UBERON:0000029 ! part of lymph node relationship: BFO:0000050 UBERON:0000029 ! part of lymph node property_value: RO:0002175 NCBITaxon:9606 property_value: terms:contributor https://orcid.org/0000-0002-2825-0621 [Term] id: UBERON:8410042 name: arteriole of lymph node def: "An arteriole that is part of a lymph node." [http://orcid.org/0000-0003-3440-1876, PMID:17067937] subset: human_reference_atlas synonym: "lymph node arteriole" EXACT [] is_a: UBERON:0001980 ! arteriole intersection_of: UBERON:0001980 ! arteriole intersection_of: BFO:0000050 UBERON:0000029 ! part of lymph node relationship: BFO:0000050 UBERON:0000029 ! part of lymph node property_value: RO:0002175 NCBITaxon:9606 property_value: terms:contributor https://orcid.org/0000-0002-2825-0621 [Term] id: UBERON:8410043 name: bronchus submucosal gland def: "A submucosal gland located in a bronchus." [http://orcid.org/0000-0003-3440-1876, http://orcid.org/0000-0003-4183-8865] subset: human_reference_atlas synonym: "airway submucosal gland" BROAD [] synonym: "bronchial submucosal gland" EXACT [] synonym: "submucosal bronchial gland" EXACT [] synonym: "submucosal bronchus gland" EXACT [] is_a: UBERON:8410077 ! airway submucosal gland intersection_of: UBERON:0011148 ! submucosal gland intersection_of: BFO:0000050 UBERON:0002185 ! part of bronchus relationship: BFO:0000050 UBERON:0002185 ! part of bronchus property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "bronchus submucosal gland" xsd:string property_value: terms:contributor https://orcid.org/0000-0002-2825-0621 [Term] id: UBERON:8410044 name: vein of appendix def: "A vein that is part of a vermiform appendix." [http://orcid.org/0000-0003-3440-1876] synonym: "vein of appendix vermiformis" EXACT [] synonym: "vein of vermiform appendix" EXACT [] is_a: UBERON:0001638 ! vein intersection_of: UBERON:0001638 ! vein intersection_of: BFO:0000050 UBERON:0001154 ! part of vermiform appendix relationship: BFO:0000050 UBERON:0001154 ! part of vermiform appendix property_value: terms:contributor https://orcid.org/0000-0002-2825-0621 [Term] id: UBERON:8410045 name: artery of appendix def: "An artery that is part of a vermiform appendix." [http://orcid.org/0000-0003-3440-1876] synonym: "artery of appendix vermiformis" EXACT [] synonym: "artery of vermiform appendix" EXACT [] is_a: UBERON:0001637 ! artery intersection_of: UBERON:0001637 ! artery intersection_of: BFO:0000050 UBERON:0001154 ! part of vermiform appendix relationship: BFO:0000050 UBERON:0001154 ! part of vermiform appendix property_value: terms:contributor https://orcid.org/0000-0002-2825-0621 [Term] id: UBERON:8410046 name: appendix smooth muscle circular layer def: "A circular muscle layer of muscular coat that is part of a vermiform appendix smooth muscle." [http://orcid.org/0000-0003-3440-1876] synonym: "smooth muscle circular layer of appendix" EXACT [] synonym: "smooth muscle circular layer of appendix vermiformis" EXACT [] synonym: "smooth muscle circular layer of vermiform appendix" EXACT [] is_a: UBERON:0012368 ! circular muscle layer of muscular coat intersection_of: UBERON:0012368 ! circular muscle layer of muscular coat intersection_of: BFO:0000050 UBERON:0001154 ! part of vermiform appendix relationship: BFO:0000050 UBERON:0001154 ! part of vermiform appendix property_value: terms:contributor https://orcid.org/0000-0002-2825-0621 [Term] id: UBERON:8410047 name: appendix smooth muscle longitudinal layer def: "A longitudinal muscle layer of muscular coat that is part of a vermiform appendix smooth muscle." [http://orcid.org/0000-0003-3440-1876] synonym: "smooth muscle longitudinal layer of appendix" EXACT [] synonym: "smooth muscle longitudinal layer of appendix vermiformis" EXACT [] synonym: "smooth muscle longitudinal layer of vermiform appendix" EXACT [] is_a: UBERON:0012369 ! longitudinal muscle layer of muscular coat intersection_of: UBERON:0012369 ! longitudinal muscle layer of muscular coat intersection_of: BFO:0000050 UBERON:0001154 ! part of vermiform appendix relationship: BFO:0000050 UBERON:0001154 ! part of vermiform appendix property_value: terms:contributor https://orcid.org/0000-0002-2825-0621 [Term] id: UBERON:8410048 name: venule of colon def: "A venule located in the colon." [https://orcid.org/0000-0003-3440-1876, https://orcid.org/0000-0003-4183-8865] is_a: UBERON:0001979 ! venule intersection_of: UBERON:0001979 ! venule intersection_of: BFO:0000050 UBERON:0001155 ! part of colon relationship: BFO:0000050 UBERON:0001155 ! part of colon property_value: skos:prefLabel "venule of colon" xsd:string property_value: terms:contributor https://orcid.org/0000-0002-2825-0621 [Term] id: UBERON:8410049 name: serosal nerve fiber of appendix def: "A nerve fiber that is located in the serosa of vermiform appendix." [http://orcid.org/0000-0003-3440-1876] synonym: "nerve fiber of serosa of appendix" EXACT [] synonym: "nerve fibre of serosa of appendix" EXACT [] synonym: "serosal nerve fiber of appendix vermiformis" EXACT [] synonym: "serosal nerve fiber of vermiform appendix" EXACT [] synonym: "serosal nerve fibre of appendix" EXACT [] synonym: "serosal nerve fibre of appendix vermiformis" EXACT [] synonym: "serosal nerve fibre of vermiform appendix" EXACT [] is_a: UBERON:0006134 ! nerve fiber intersection_of: UBERON:0006134 ! nerve fiber intersection_of: BFO:0000050 UBERON:0012498 ! part of serosa of appendix relationship: BFO:0000050 UBERON:0012498 ! part of serosa of appendix property_value: terms:contributor https://orcid.org/0000-0002-2825-0621 [Term] id: UBERON:8410050 name: anorectum def: "A subdivision of the digestive tract in humans that includes the rectum, the anal canal and the anus." [DOI:10.1007/978-3-319-26938-2_8, DOI:10.1148/rg.2015150037, http://orcid.org/0000-0002-6826-8770, http://orcid.org/0000-0003-3440-1876, PMID:29742860] synonym: "anorectal canal" NARROW [] is_a: BFO:0000002 is_a: UBERON:0004921 ! subdivision of digestive tract intersection_of: UBERON:0004921 ! subdivision of digestive tract intersection_of: BFO:0000051 UBERON:0000159 ! has part anal canal intersection_of: BFO:0000051 UBERON:0001052 ! has part rectum intersection_of: BFO:0000051 UBERON:0001245 ! has part anus relationship: BFO:0000050 UBERON:0000059 ! part of large intestine relationship: BFO:0000051 UBERON:0000159 ! has part anal canal relationship: BFO:0000051 UBERON:0001052 ! has part rectum relationship: BFO:0000051 UBERON:0001245 ! has part anus property_value: IAO:0000116 "The anatomy, pathology and medical community considers the anus to be part of the large intestine, and supports the use of 'anorectum' to include rectum, anal canal and anus. Although a few resources seem to only include the distal part of the rectum in 'anorectum', this UBERON grouping term is meant to refer more broadly to the whole of rectum." xsd:string property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "anorectum" xsd:string property_value: terms:contributor https://orcid.org/0000-0002-2825-0621 [Term] id: UBERON:8410051 name: lymphatic vessel of colon def: "A lymphatic vessel located in the colon." [https://orcid.org/0000-0003-3440-1876, https://orcid.org/0000-0003-4183-8865] is_a: UBERON:0001473 ! lymphatic vessel intersection_of: UBERON:0001473 ! lymphatic vessel intersection_of: BFO:0000050 UBERON:0001155 ! part of colon relationship: BFO:0000050 UBERON:0001155 ! part of colon property_value: terms:contributor https://orcid.org/0000-0002-2825-0621 [Term] id: UBERON:8410052 name: lymph node germinal center light zone def: "Lymph node germinal centers contain two microenvironments: the light zone and the dark zone. The light zone is sparsely populated with B cells and includes additional cell types such as follicular dendritic cells, lymph node tingible macrophages and T follicular helper cells." [http://orcid.org/0000-0003-4183-8865, PMID:25656706, PMID:8011279] subset: human_reference_atlas synonym: "germinal center light zone" BROAD [] synonym: "light zone of germinal center" BROAD [] synonym: "light zone of lymph node germinal center" EXACT [] is_a: UBERON:0001744 ! lymphoid tissue relationship: BFO:0000050 UBERON:0009039 ! part of lymph node germinal center property_value: RO:0002175 NCBITaxon:9606 property_value: terms:contributor https://orcid.org/0000-0002-2825-0621 [Term] id: UBERON:8410053 name: lymph node germinal center dark zone def: "Lymph node germinal centers contain two microenvironments: the light zone and the dark zone. The dark zone is densely populated with B cell blasts and reticular cells." [http://orcid.org/0000-0003-4183-8865, PMID:25656706, PMID:8011279] subset: human_reference_atlas synonym: "dark zone of germinal center" BROAD [] synonym: "dark zone of lymph node germinal center" EXACT [] synonym: "germinal center dark zone" BROAD [] is_a: UBERON:0001744 ! lymphoid tissue relationship: BFO:0000050 UBERON:0009039 ! part of lymph node germinal center property_value: RO:0002175 NCBITaxon:9606 property_value: terms:contributor https://orcid.org/0000-0002-2825-0621 [Term] id: UBERON:8410056 name: capillary of anorectum def: "A capillary that is part of the anorectum." [http://orcid.org/0000-0003-3440-1876] synonym: "blood vessel capillary of anorectum" EXACT [] is_a: UBERON:0001982 ! capillary intersection_of: UBERON:0001982 ! capillary intersection_of: BFO:0000050 UBERON:8410050 ! part of anorectum relationship: BFO:0000050 UBERON:8410050 ! part of anorectum property_value: skos:prefLabel "capillary of anorectum" xsd:string property_value: terms:contributor https://orcid.org/0000-0002-2825-0621 [Term] id: UBERON:8410057 name: capillary of colon def: "A capillary that is part of the colon." [http://orcid.org/0000-0003-3440-1876] synonym: "blood vessel capillary of colon" EXACT [] is_a: UBERON:0001982 ! capillary intersection_of: UBERON:0001982 ! capillary intersection_of: BFO:0000050 UBERON:0001155 ! part of colon relationship: BFO:0000050 UBERON:0001155 ! part of colon property_value: skos:prefLabel "capillary of colon" xsd:string property_value: terms:contributor https://orcid.org/0000-0002-2825-0621 [Term] id: UBERON:8410058 name: myenteric nerve plexus of colon def: "Myenteric nerve plexus that is located in the colon." [http://orcid.org/0000-0003-3440-1876] subset: human_reference_atlas is_a: UBERON:0002439 ! myenteric nerve plexus intersection_of: UBERON:0002439 ! myenteric nerve plexus intersection_of: BFO:0000050 UBERON:0001155 ! part of colon relationship: BFO:0000050 UBERON:0001155 ! part of colon property_value: RO:0002175 NCBITaxon:9606 property_value: terms:contributor https://orcid.org/0000-0002-2825-0621 [Term] id: UBERON:8410060 name: colon smooth muscle circular layer def: "A circular muscle layer of muscular coat that is part of a colon smooth muscle." [http://orcid.org/0000-0003-3440-1876] synonym: "smooth muscle circular layer of colon" EXACT [] is_a: UBERON:0012398 ! large intestine smooth muscle circular layer intersection_of: UBERON:0012368 ! circular muscle layer of muscular coat intersection_of: BFO:0000050 UBERON:0001155 ! part of colon intersection_of: BFO:0000050 UBERON:0004220 ! part of large intestine smooth muscle relationship: BFO:0000050 UBERON:0001155 ! part of colon property_value: terms:contributor https://orcid.org/0000-0002-2825-0621 [Term] id: UBERON:8410061 name: colon smooth muscle longitudinal layer def: "A longitudinal muscle layer of muscular coat that is part of a colon smooth muscle." [http://orcid.org/0000-0003-3440-1876] synonym: "smooth muscle longitudinal layer of colon" EXACT [] is_a: UBERON:0012399 ! large intestine smooth muscle longitudinal layer intersection_of: UBERON:0012369 ! longitudinal muscle layer of muscular coat intersection_of: BFO:0000050 UBERON:0001155 ! part of colon intersection_of: BFO:0000050 UBERON:0004220 ! part of large intestine smooth muscle relationship: BFO:0000050 UBERON:0001155 ! part of colon property_value: terms:contributor https://orcid.org/0000-0002-2825-0621 [Term] id: UBERON:8410063 name: myenteric nerve plexus of small intestine def: "Myenteric nerve plexus that is part of the small intestine." [http://orcid.org/0000-0003-3440-1876] subset: human_reference_atlas is_a: UBERON:0002439 ! myenteric nerve plexus intersection_of: UBERON:0002439 ! myenteric nerve plexus intersection_of: BFO:0000050 UBERON:0002108 ! part of small intestine relationship: BFO:0000050 UBERON:0002108 ! part of small intestine property_value: RO:0002175 NCBITaxon:9606 property_value: terms:contributor https://orcid.org/0000-0002-2825-0621 [Term] id: UBERON:8410065 name: lymph node follicle marginal zone def: "Histologically, the marginal zone pattern of the lymph node is characterized by lymphoid follicles with three distinct layers. The inner layer is composed of follicular center zones, the middle layer of darkly stained mantle zones, and the outer layer of marginal zones. However, the marginal zone pattern is rarely seen in reactive lymph nodes except for mesenteric lymph nodes. Lymph node marginal zones are populated by marginal zone B cells which express CD19 and CD20 and have the phenotypic features of memory B cells." [http://orcid.org/0000-0003-4183-8865, PMID:11026094, PMID:12076268] synonym: "lymph node marginal zone" BROAD [] synonym: "marginal zone of lymph node" BROAD [] synonym: "marginal zone of lymph node follicle" EXACT [] is_a: UBERON:0001744 ! lymphoid tissue relationship: BFO:0000050 UBERON:0000029 ! part of lymph node property_value: terms:contributor https://orcid.org/0000-0002-2825-0621 [Term] id: UBERON:8410066 name: lymph node paracortex def: "The lymph node paracortex is the middle layer of the lymph node and is mostly populated by T cells and dendritic cells. The paracortex also contains specialised blood vessels called high endothelial venules which allow lymphocytes to enter the node." [http://orcid.org/0000-0001-9990-8331, http://orcid.org/0000-0003-4183-8865, https://www.immunology.org/public-information/bitesized-immunology/organs-and-tissues/lymph-node] subset: human_reference_atlas is_a: UBERON:0001744 ! lymphoid tissue relationship: BFO:0000050 UBERON:0010417 ! part of lymph node T cell domain property_value: RO:0002175 NCBITaxon:9606 property_value: terms:contributor https://orcid.org/0000-0002-2825-0621 [Term] id: UBERON:8410068 name: capillary of small intestine def: "A capillary that is part of a small intestine." [http://orcid.org/0000-0003-3440-1876] subset: location_grouping synonym: "blood vessel capillary of small intestine" EXACT [] synonym: "small intestine capillary" EXACT [] is_a: UBERON:0001982 ! capillary intersection_of: UBERON:0001982 ! capillary intersection_of: BFO:0000050 UBERON:0002108 ! part of small intestine relationship: BFO:0000050 UBERON:0002108 ! part of small intestine property_value: skos:prefLabel "capillary of small intestine" xsd:string property_value: terms:contributor https://orcid.org/0000-0002-2825-0621 property_value: terms:date "2021-12-21T15:14:31Z" xsd:dateTime [Term] id: UBERON:8410071 name: subcapsular sinus ceiling def: "The section of the lymph node capsule that faces the subcapsular sinus. In human, it's characterized by specific protein markers." [https://orcid.org/0000-0001-7655-4833, PMID:31402260] subset: human_reference_atlas synonym: "ceiling of subcapsular sinus of lymph node" EXACT [] synonym: "floor of capsule of lymph node" EXACT [] synonym: "subcapsular sinus of lymph node ceiling" EXACT [] is_a: UBERON:0000064 ! organ part relationship: BFO:0000050 UBERON:0002194 ! part of capsule of lymph node relationship: RO:0002220 UBERON:0005463 ! adjacent to subcapsular sinus of lymph node property_value: RO:0002175 NCBITaxon:9606 property_value: terms:contributor https://orcid.org/0000-0002-2825-0621 property_value: terms:date "2022-02-22T17:04:49Z" xsd:dateTime [Term] id: UBERON:8410072 name: subcapsular sinus floor def: "The section of the lymph node cortex that faces the subcapsular sinus. In human, it's characterized by specific protein markers." [https://orcid.org/0000-0001-7655-4833, PMID:31402260] subset: human_reference_atlas synonym: "ceiling of cortex of lymph node" EXACT [] synonym: "floor of subcapsular sinus of lymph node" EXACT [] synonym: "subcapsular sinus of lymph node floor" EXACT [] is_a: UBERON:0000064 ! organ part relationship: BFO:0000050 UBERON:0002006 ! part of cortex of lymph node relationship: RO:0002220 UBERON:0005463 ! adjacent to subcapsular sinus of lymph node property_value: RO:0002175 NCBITaxon:9606 property_value: terms:contributor https://orcid.org/0000-0002-2825-0621 property_value: terms:date "2022-02-22T17:16:40Z" xsd:dateTime [Term] id: UBERON:8410077 name: airway submucosal gland def: "A submucosal gland found in a respiratory tract." [http://orcid.org/0000-0003-3440-1876, http://orcid.org/0000-0003-4183-8865] synonym: "respiratory tract submucosal gland" EXACT [] synonym: "submucosal gland of respiratory tract" EXACT [] xref: EFO:0010666 is_a: UBERON:0011148 ! submucosal gland is_a: UBERON:0036225 ! respiratory system gland intersection_of: UBERON:0011148 ! submucosal gland intersection_of: BFO:0000050 UBERON:0000065 ! part of respiratory tract relationship: BFO:0000050 UBERON:0000065 ! part of respiratory tract property_value: skos:prefLabel "airway submucosal gland" xsd:string property_value: terms:contributor https://orcid.org/0000-0002-2825-0621 property_value: terms:date "2022-03-24T14:21:59Z" xsd:dateTime [Term] id: UBERON:8410080 name: red bone marrow of sternum def: "Red bone marrow located in the sternum." [http://orcid.org/0000-0001-7655-4833] synonym: "sternum red bone marrow" EXACT [] is_a: UBERON:0000361 ! red bone marrow intersection_of: UBERON:0000361 ! red bone marrow intersection_of: BFO:0000050 UBERON:0000975 ! part of sternum relationship: BFO:0000050 UBERON:0000975 ! part of sternum [Term] id: UBERON:8410081 name: blood microvessel def: "Any of the smallest blood vessels where blood circulates within organ tissues. Microvessels include terminal arterioles, metarterioles, capillaries, and venules (but exclude lymphatic capillaries). Arterioles carry oxygenated blood to the capillaries, and blood flows out of the capillaries through venules into veins." [http://orcid.org/0000-0002-7073-9172, Wikipedia:Microcirculation] synonym: "microvasculature" BROAD [] synonym: "microvessel" BROAD [] is_a: UBERON:0001981 ! blood vessel is_a: UBERON:0010523 ! microcirculatory vessel property_value: seeAlso "https://github.com/obophenotype/uberon/issues/2186" xsd:string property_value: skos:prefLabel "blood microvessel" xsd:string [Term] id: UBERON:8420000 name: hair of scalp def: "Hair that grows on the scalp." [PMID:3126903] synonym: "hair" BROAD [PMID:30783333] is_a: UBERON:0016446 ! hair of head intersection_of: UBERON:0001037 ! strand of hair intersection_of: BFO:0000050 UBERON:0000403 ! part of scalp relationship: BFO:0000050 UBERON:0000403 ! part of scalp property_value: terms:contributor https://orcid.org/0000-0001-8314-2140 [Term] id: UBERON:8440000 name: cortical layer II/III def: "A laminar subdivision of the neocortex that is comprised of a part of layer II and a part of layer III." [PMID:34616063] comment: In rodents, layer II/III refers to a mereological sum of layers II and III as there is no clear architectonic boundary between them. {xref="PMID:29311847"} synonym: "cerebral cortex layer 2/3" EXACT [] synonym: "neocortex layer 2/3" EXACT [] is_a: UBERON:8440004 ! laminar subdivision of the cortex property_value: skos:prefLabel "cortical layer II/III" xsd:string [Term] id: UBERON:8440001 name: cortical layer IV/V def: "A laminar subdivision of the neocortex that is comprised of a part of layer IV and a part of layer V." [PMID:34616063] synonym: "cerebral cortex layer 4/5" EXACT [] synonym: "neocortex layer 4/5" EXACT [] is_a: UBERON:8440004 ! laminar subdivision of the cortex [Term] id: UBERON:8440002 name: cortical layer V/VI def: "A laminar subdivision of the neocortex that is comprised of a part of layer V and a part of layer VI." [PMID:34616063] synonym: "cerebral cortex layer 5/6" EXACT [] synonym: "neocortex layer 5/6" EXACT [] is_a: UBERON:8440004 ! laminar subdivision of the cortex [Term] id: UBERON:8440003 name: cortical layer VIb def: "The deepest layer of the neocortex. While layer 6b is considered part of layer 6, it is distinct morphologically, genetically, and developmentally from the rest of layer 6. Neurons in L6b project to cortical targets and higher-order thalamus and develop from a precursor population that arises from the subplate." [PMID:32160552] synonym: "cerebral cortex layer 6b" EXACT [] synonym: "neocortex layer 6b" EXACT [] is_a: BFO:0000002 is_a: UBERON:0002301 ! layer of neocortex relationship: BFO:0000050 UBERON:0005395 ! part of cortical layer VI relationship: RO:0002202 UBERON:0004035 ! develops from cortical subplate property_value: skos:prefLabel "cortical layer VIb" xsd:string [Term] id: UBERON:8440004 name: laminar subdivision of the cortex def: "One or a subset of adjacent layers of the neocortex." [ISBN-10:0-87893-742-0] is_a: UBERON:0011215 ! central nervous system cell part cluster relationship: BFO:0000050 UBERON:0001950 ! part of neocortex property_value: skos:prefLabel "laminar subdivision of the cortex" xsd:string [Term] id: UBERON:8440005 name: rostral periventricular region of the third ventricle def: "A functional anatomical construct containing the key estrogen-regulated inputs to gonadotropin-releasing hormone expressing (GnRH) neurons necessary for estrogen positive feedback. The rostral periventricular region of the third ventricle contains a population of neurons, scattered through the nuclei of the anteroventral periventricular (AVPV), periventricular preoptic (PVpo), and median preoptic (MEPO), that project directly to GnRH neurons and express ER-alpha." [PMID:17604108] comment: In rats and mice, the anteroventral periventricular nucleus plus the periventricular nucleus make up the rostral periventricular region of the third ventricle (RP3V). Overlaps is used (instead of has_part that this comment suggests should be used) as PMID:17604108 suggest that the region refers to cells that are scattered in the area. {xref="WikipediaVersioned:Anteroventral_periventricular_nucleus&oldid=966137187"} synonym: "RP3V" EXACT [PMID:17604108] is_a: UBERON:0035014 ! functional part of brain relationship: BFO:0000050 UBERON:0006569 ! part of diencephalic nucleus relationship: RO:0002131 UBERON:0002622 ! overlaps preoptic periventricular nucleus relationship: RO:0002131 UBERON:0002625 ! overlaps median preoptic nucleus relationship: RO:0002131 UBERON:0002690 ! overlaps anteroventral periventricular nucleus property_value: skos:prefLabel "rostral periventricular region of the third ventricle" xsd:string [Term] id: UBERON:8440008 name: periventricular hypothalamic nucleus, intermediate part def: "The intermediate part of the periventricular hypothalamic nucleus." [MBA:118] comment: This seperation is based on the Allen mouse brain atlas. synonym: "PVi" EXACT [MBA:118] xref: MBA:118 is_a: UBERON:0006568 ! hypothalamic nucleus relationship: BFO:0000050 UBERON:0002271 ! part of periventricular zone of hypothalamus property_value: skos:prefLabel "periventricular hypothalamic nucleus, intermediate part" xsd:string [Term] id: UBERON:8440011 name: cortical visual area def: "The part of the cortex that is responsible for processing visual information." [https://orcid.org/0000-0001-7258-9596] is_a: UBERON:0035014 ! functional part of brain intersection_of: UBERON:0035014 ! functional part of brain intersection_of: BFO:0000050 UBERON:0000956 ! part of cerebral cortex intersection_of: RO:0002216 GO:0007601 ! capable of part of visual perception relationship: BFO:0000050 UBERON:0000956 ! part of cerebral cortex relationship: RO:0002216 GO:0007601 ! capable of part of visual perception property_value: skos:prefLabel "cortical visual area" xsd:string property_value: terms:contributor https://orcid.org/0000-0001-7258-9596 [Term] id: UBERON:8440012 name: cerebral nuclei def: "One of three components of the cerebrum that is a composite structure of the endbrain defined on the basis of origin from the ventricular ridge of the embryonic Encephalon. It consists of the extended striatum and the extended pallidum." [neuronames:2677] comment: This was added as a more precise mapping to the Allen brain atlas (as opposed to collection of basal ganglia) synonym: "CNU" EXACT [MBA:623] xref: DHBA:10331 xref: HBA:4275 xref: MBA:623 xref: PBA:128012596 is_a: UBERON:0009663 ! telencephalic nucleus property_value: skos:prefLabel "cerebral nuclei" xsd:string [Term] id: UBERON:8440015 name: noradrenergic cell groups def: "Collections of neurons in the central nervous system that have been demonstrated by histochemical fluorescence to contain the neurotransmitter norepinephrine (noradrenalin)." [WikipediaVersioned:Noradrenergic_cell_groups&oldid=965992184] is_a: UBERON:0002616 ! regional part of brain relationship: RO:0002473 CL:0000459 ! composed primarily of noradrenergic cell property_value: skos:prefLabel "noradrenergic cell groups" xsd:string [Term] id: UBERON:8440030 name: striatum-like amygdalar nuclei def: "A part of the striatum which is primarilly composed of amygdalar areas. The sAMY is composed of the anterior amygdalar area, central amygdalar nucleus, intercalated amygdalar nucleus, medial amygdalar nucleus, and the bed nucleus of the accessory olfactory tract." [MBA:278] synonym: "sAMY" EXACT [MBA:278] xref: MBA:278 is_a: UBERON:0009663 ! telencephalic nucleus relationship: BFO:0000050 UBERON:0002435 ! part of striatum property_value: skos:prefLabel "striatum-like amygdalar nuclei" xsd:string [Term] id: UBERON:8440043 name: superior paraolivary nucleus def: "A structure embedded in the superior olivary complex that is driven by input pathways from the octopus cells in the cochlear nucleus and the neurons of the medial nucleus of the trapezoid body." [DOI:10.1093/oxfordhb/9780190849061.013.11] synonym: "SPON" EXACT [DOI:10.1093/oxfordhb/9780190849061.013.11] is_a: UBERON:0007247 ! nucleus of superior olivary complex property_value: terms:contributor https://orcid.org/0000-0001-7258-9596 [Term] id: UBERON:8440076 name: somatomotor area def: "A part of the cerebral cortex that comprises of the primary motor cortex and the premotor cortex." [MBA:500] xref: MBA:500 is_a: UBERON:0002616 ! regional part of brain relationship: BFO:0000051 UBERON:0001384 ! has part primary motor cortex relationship: BFO:0000051 UBERON:0016634 ! has part premotor cortex property_value: skos:prefLabel "somatomotor area" xsd:string property_value: terms:contributor https://orcid.org/0000-0001-7258-9596 [Term] id: UBERON:8450001 name: egg follicle def: "An individual reproductive unit containing a single oocyte and one or several layers of support cells (Armstrong et al., 2020)." [DOI:10.1530/REP-18-0593] is_a: UBERON:0000064 ! organ part is_a: UBERON:0005156 ! reproductive structure relationship: BFO:0000050 UBERON:0000992 ! part of ovary property_value: seeAlso "https://github.com/obophenotype/uberon/issues/476" xsd:anyURI property_value: terms:contributor https://orcid.org/0000-0002-6095-8718 property_value: terms:date "2022-04-19T11:08:10Z" xsd:dateTime [Term] id: UBERON:8450002 name: excretory system def: "An anatomical system that eliminates waste products that arise as a result of metabolic activity." [GO:0007588] subset: human_reference_atlas is_a: UBERON:0000467 ! anatomical system intersection_of: UBERON:0000467 ! anatomical system intersection_of: RO:0002215 GO:0046903 ! capable of secretion relationship: RO:0002215 GO:0046903 ! capable of secretion property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "excretory system" xsd:string creation_date: 2022-05-25T18:21:29Z [Term] id: UBERON:8450003 name: embryonic craniocervical region def: "A craniocervical region that is part of an embryo." [https://orcid.org/0000-0002-6095-8718] is_a: UBERON:0007811 ! craniocervical region intersection_of: UBERON:0007811 ! craniocervical region intersection_of: BFO:0000050 UBERON:0000922 ! part of embryo relationship: BFO:0000050 UBERON:0000922 ! part of embryo property_value: skos:prefLabel "embryonic craniocervical region" xsd:string property_value: terms:contributor https://orcid.org/0000-0002-6095-8718 property_value: terms:date "2024-09-12T14:40:00Z" xsd:dateTime [Term] id: UBERON:8470000 name: placental blood def: "Blood located in the placenta." [http://orcid.org/0000-0001-6595-0902, https://www.ncbi.nlm.nih.gov/books/NBK53254/] is_a: UBERON:0000178 ! blood intersection_of: UBERON:0000178 ! blood intersection_of: RO:0001025 UBERON:0001987 ! located in placenta relationship: RO:0001025 UBERON:0001987 ! located in placenta property_value: terms:date "2022-04-04T11:06:09Z" xsd:dateTime [Term] id: UBERON:8470001 name: sublumbar lymph node def: "A lymph node with a lymph center located within the caudal abdomen and pelvis, on the ventral side of the lumbar region. Includes the medial iliac, internal iliac (previously termed hypogastric) and sacral lymph nodes." [https://orcid.org/0000-0002-0819-0473, NCIT:C77655, PMID:32655159] is_a: UBERON:0000029 ! lymph node property_value: terms:date "2022-05-26T11:59:51Z" xsd:dateTime [Term] id: UBERON:8480000 name: iliac vein smooth muscle tissue def: "A portion of smooth muscle tissue that is part of an iliac vein." [https://orcid.org/0000-0002-0819-0473] is_a: UBERON:0004696 ! venous system smooth muscle intersection_of: UBERON:0001135 ! smooth muscle tissue intersection_of: BFO:0000050 UBERON:0005610 ! part of iliac vein relationship: BFO:0000050 UBERON:0005610 ! part of iliac vein property_value: terms:contributor https://orcid.org/0000-0002-0819-0473 property_value: terms:date "2022-06-17T14:34:50Z" xsd:dateTime [Term] id: UBERON:8480001 name: capillary of brain def: "A capillary that is part of the brain." [https://orcid.org/0000-0002-0819-0473] is_a: UBERON:0001982 ! capillary is_a: UBERON:0003499 ! brain blood vessel intersection_of: UBERON:0001982 ! capillary intersection_of: BFO:0000050 UBERON:0000955 ! part of brain property_value: skos:prefLabel "capillary of brain" xsd:string property_value: terms:contributor https://orcid.org/0000-0002-0819-0473 property_value: terms:date "2022-06-24T09:28:31Z" xsd:dateTime [Term] id: UBERON:8480002 name: thoracic aorta smooth muscle tissue def: "A portion of smooth muscle tissue that is part of the thoracic aorta." [https://orcid.org/0000-0002-0819-0473] is_a: UBERON:0004178 ! aorta smooth muscle tissue intersection_of: UBERON:0001135 ! smooth muscle tissue intersection_of: BFO:0000050 UBERON:0001515 ! part of thoracic aorta relationship: BFO:0000050 UBERON:0001515 ! part of thoracic aorta property_value: skos:prefLabel "thoracic aorta smooth muscle tissue" xsd:string property_value: terms:contributor https://orcid.org/0000-0002-0819-0473 property_value: terms:date "2022-06-24T09:30:54Z" xsd:dateTime [Term] id: UBERON:8480003 name: iliac artery smooth muscle tissue def: "A portion of smooth muscle tissue that is part of an iliac artery." [https://orcid.org/0000-0002-0819-0473] is_a: UBERON:0002111 ! artery smooth muscle tissue intersection_of: UBERON:0001135 ! smooth muscle tissue intersection_of: BFO:0000050 UBERON:0005609 ! part of iliac artery relationship: BFO:0000050 UBERON:0005609 ! part of iliac artery property_value: terms:contributor https://orcid.org/0000-0002-0819-0473 property_value: terms:date "2022-06-24T09:32:07Z" xsd:dateTime [Term] id: UBERON:8480004 name: iliac vein endothelium def: "An endothelium that is part of an iliac vein." [https://orcid.org/0000-0002-0819-0473] is_a: UBERON:0001919 ! endothelium of vein intersection_of: UBERON:0001986 ! endothelium intersection_of: BFO:0000050 UBERON:0005610 ! part of iliac vein relationship: BFO:0000050 UBERON:0005610 ! part of iliac vein property_value: terms:contributor https://orcid.org/0000-0002-0819-0473 property_value: terms:date "2022-06-24T09:33:18Z" xsd:dateTime [Term] id: UBERON:8480005 name: placental artery endothelium def: "An endothelium that is part of the placental artery." [https://orcid.org/0000-0002-0819-0473] is_a: UBERON:0001917 ! endothelium of artery is_a: UBERON:0005156 ! reproductive structure is_a: UBERON:0005292 ! extraembryonic tissue intersection_of: UBERON:0001986 ! endothelium intersection_of: BFO:0000050 UBERON:8480007 ! part of placental artery relationship: BFO:0000050 UBERON:8480007 ! part of placental artery property_value: terms:contributor https://orcid.org/0000-0002-0819-0473 property_value: terms:date "2022-06-24T09:34:25Z" xsd:dateTime [Term] id: UBERON:8480006 name: mesenteric lymphatic vessel def: "Lymphatic vessel that is part of the mesentery." [https://orcid.org/0000-0002-0819-0473] is_a: UBERON:0001473 ! lymphatic vessel intersection_of: UBERON:0001473 ! lymphatic vessel intersection_of: BFO:0000050 UBERON:0002095 ! part of mesentery relationship: BFO:0000050 UBERON:0002095 ! part of mesentery property_value: terms:contributor https://orcid.org/0000-0002-0819-0473 property_value: terms:date "2022-06-24T09:35:29Z" xsd:dateTime [Term] id: UBERON:8480007 name: placental artery def: "An artery that is part of the placenta." [https://orcid.org/0000-0002-0819-0473] is_a: UBERON:0001637 ! artery is_a: UBERON:0022358 ! placenta blood vessel intersection_of: UBERON:0001637 ! artery intersection_of: BFO:0000050 UBERON:0001987 ! part of placenta property_value: terms:contributor https://orcid.org/0000-0002-0819-0473 property_value: terms:date "2022-06-24T11:25:24Z" xsd:dateTime [Term] id: UBERON:8480008 name: placental vein def: "A vein that is part of the placenta." [https://orcid.org/0000-0002-0819-0473] is_a: UBERON:0001638 ! vein is_a: UBERON:0022358 ! placenta blood vessel intersection_of: UBERON:0001638 ! vein intersection_of: BFO:0000050 UBERON:0001987 ! part of placenta property_value: terms:contributor https://orcid.org/0000-0002-0819-0473 property_value: terms:date "2022-06-27T09:30:52Z" xsd:dateTime [Term] id: UBERON:8480024 name: skin of sacral region def: "A zone of skin that is part of the sacral region." [https://orcid.org/0000-0002-0819-0473] is_a: UBERON:0001415 ! skin of pelvis intersection_of: UBERON:0000014 ! zone of skin intersection_of: BFO:0000050 UBERON:0005473 ! part of sacral region relationship: BFO:0000050 UBERON:0005473 ! part of sacral region property_value: terms:contributor https://orcid.org/0000-0002-0819-0473 property_value: terms:date "2022-08-29T14:14:27Z" xsd:dateTime [Term] id: UBERON:8480025 name: skin of clavicle region def: "A zone of skin that is above the clavicle zone in the pectoral girdle region." [https://orcid.org/0000-0002-0819-0473] is_a: UBERON:0000014 ! zone of skin intersection_of: UBERON:0000014 ! zone of skin intersection_of: BFO:0000050 UBERON:0001421 ! part of pectoral girdle region relationship: BFO:0000050 UBERON:0001421 ! part of pectoral girdle region property_value: skos:prefLabel "skin of clavicle region" xsd:string property_value: terms:contributor https://orcid.org/0000-0002-0819-0473 property_value: terms:date "2022-08-29T14:17:12Z" xsd:dateTime [Term] id: UBERON:8480026 name: skin of iliac crest region def: "A zone of skin that is above the iliac crest in the pelvic girdle bone/zone." [https://orcid.org/0000-0002-0819-0473] synonym: "skin of posterior iliac crest region" BROAD [] is_a: UBERON:0001415 ! skin of pelvis intersection_of: UBERON:0000014 ! zone of skin intersection_of: BFO:0000050 UBERON:0007830 ! part of pelvic girdle bone/zone relationship: BFO:0000050 UBERON:0007830 ! part of pelvic girdle bone/zone property_value: terms:contributor https://orcid.org/0000-0002-0819-0473 property_value: terms:date "2022-08-29T14:19:16Z" xsd:dateTime [Term] id: UBERON:8480029 name: skin of external genitalia def: "A zone of skin that is part of the external genitalia." [https://orcid.org/0000-0002-0819-0473] is_a: UBERON:0000014 ! zone of skin is_a: UBERON:0005156 ! reproductive structure intersection_of: UBERON:0000014 ! zone of skin intersection_of: BFO:0000050 UBERON:0004176 ! part of external genitalia relationship: BFO:0000050 UBERON:0004176 ! part of external genitalia property_value: skos:prefLabel "skin of external genitalia" xsd:string property_value: terms:contributor https://orcid.org/0000-0002-0819-0473 property_value: terms:date "2022-08-30T06:55:06Z" xsd:dateTime [Term] id: UBERON:8480030 name: skin of breast def: "A zone of skin that is part of the breast." [https://orcid.org/0000-0002-0819-0473] is_a: UBERON:0001868 ! skin of chest intersection_of: UBERON:0000014 ! zone of skin intersection_of: BFO:0000050 UBERON:0000310 ! part of breast relationship: BFO:0000050 UBERON:0000310 ! part of breast property_value: terms:contributor https://orcid.org/0000-0002-0819-0473 property_value: terms:date "2022-08-29T14:03:54Z" xsd:dateTime [Term] id: UBERON:8480037 name: subserosa of fallopian tube def: "Subserosa that is part of the uterine tube. It contains loose connective tissue, blood vessels and lymphatic tissue." [ISBN:9783662026762, PMID:30095490] synonym: "subserosa of oviduct" EXACT [PMID:34440264] synonym: "subserosa of uterine tube" EXACT [] is_a: UBERON:0005156 ! reproductive structure is_a: UBERON:0012375 ! subserosa intersection_of: UBERON:0012375 ! subserosa intersection_of: BFO:0000050 UBERON:0003889 ! part of fallopian tube relationship: BFO:0000050 UBERON:0003889 ! part of fallopian tube property_value: terms:contributor https://orcid.org/0000-0002-0819-0473 property_value: terms:date "2022-10-21T08:55:11Z" xsd:dateTime [Term] id: UBERON:8480068 name: saphenous vein smooth muscle tissue def: "A portion of smooth muscle tissue that is part of a saphenous vein." [https://orcid.org/0000-0002-0819-0473] is_a: UBERON:0004696 ! venous system smooth muscle intersection_of: UBERON:0001135 ! smooth muscle tissue intersection_of: BFO:0000050 UBERON:0007318 ! part of saphenous vein relationship: BFO:0000050 UBERON:0007318 ! part of saphenous vein property_value: terms:contributor https://orcid.org/0000-0002-0819-0473 property_value: terms:date "2023-08-31T11:41:09Z" xsd:dateTime [Term] id: UBERON:8480069 name: temporofacial region def: "The region at each side of the face comprising the temple and the cheek." [PMID:28448262] comment: This term is used to map the tissue from which the Muraoka cell line (CVCL_E042) originates. {xref="PMID:1357816"} is_a: UBERON:0001444 ! subdivision of head relationship: RO:0002131 UBERON:0001456 ! overlaps face property_value: terms:contributor https://orcid.org/0000-0002-0819-0473 property_value: terms:date "2023-09-18T06:03:43Z" xsd:dateTime [Term] id: UBERON:8480074 name: skin of gonad def: "A zone of skin part of some gonad." [https://orcid.org/0000-0002-0819-0473] is_a: UBERON:0000014 ! zone of skin is_a: UBERON:0005156 ! reproductive structure intersection_of: UBERON:0000014 ! zone of skin intersection_of: BFO:0000050 UBERON:0000991 ! part of gonad relationship: BFO:0000050 UBERON:0000991 ! part of gonad property_value: skos:prefLabel "skin of gonad" xsd:string property_value: terms:contributor https://orcid.org/0000-0002-0819-0473 property_value: terms:date "2023-08-29T10:24:24Z" xsd:dateTime [Term] id: UBERON:8600000 name: lobular bronchiole def: "A conductive airway that branches into terminal bronchioles." [PMID:16543587, PMID:27611890] subset: human_reference_atlas synonym: "preterminal bronchiole" EXACT [PMID:16543587] is_a: UBERON:0002186 ! bronchiole property_value: RO:0002175 NCBITaxon:9606 property_value: terms:contributor https://orcid.org/0000-0001-6677-8489 property_value: terms:date "2023-02-08T13:31:12Z" xsd:dateTime [Term] id: UBERON:8600001 name: epithelium of lobular bronchiole def: "An epithelium of the lobular bronchiole." [FMA:62497] synonym: "epithelium of preterminal bronchiole" EXACT [PMID:16543587] synonym: "lobular bronchiole epithelium" EXACT [FMA:62497] is_a: UBERON:0002051 ! epithelium of bronchiole intersection_of: UBERON:0000483 ! epithelium intersection_of: BFO:0000050 UBERON:8600000 ! part of lobular bronchiole relationship: BFO:0000050 UBERON:8600000 ! part of lobular bronchiole property_value: terms:contributor https://orcid.org/0000-0001-6677-8489 property_value: terms:date "2023-02-10T14:26:09Z" xsd:dateTime [Term] id: UBERON:8600002 name: mucosa of lobular bronchiole def: "A mucosa that is part of a lobular bronchiole." [FMA:263230] is_a: UBERON:0005039 ! mucosa of bronchiole intersection_of: UBERON:0000344 ! mucosa intersection_of: BFO:0000050 UBERON:8600000 ! part of lobular bronchiole relationship: BFO:0000050 UBERON:8600000 ! part of lobular bronchiole property_value: terms:contributor https://orcid.org/0000-0001-6677-8489 property_value: terms:date "2023-02-10T14:48:35Z" xsd:dateTime [Term] id: UBERON:8600003 name: smooth muscle tissue of lobular bronchiole def: "A smooth muscle tissue that is part of a lobular bronchiole." [FMA:261081] is_a: UBERON:0004515 ! smooth muscle tissue of bronchiole intersection_of: UBERON:0001135 ! smooth muscle tissue intersection_of: BFO:0000050 UBERON:8600000 ! part of lobular bronchiole relationship: BFO:0000050 UBERON:8600000 ! part of lobular bronchiole property_value: terms:contributor https://orcid.org/0000-0001-6677-8489 property_value: terms:date "2023-02-10T14:54:06Z" xsd:dateTime [Term] id: UBERON:8600004 name: visceral muscle tissue def: "A muscle tissue that is associated with soft internal organs (viscera)." [BTO:0002780, CLAO:0001295] comment: It is quite common to refer to visceral muscles as smooth muscles, by analogy with vertebrates; however, most visceral muscles in arthropods are actually striated. {xref="https://en.wikipedia.org/wiki/Smooth_muscle", xref="FBbt:00005070", comment="PMID:8720463"} synonym: "visceral muscle" EXACT [] {comment="BTO:0002780"} is_a: UBERON:0002385 ! muscle tissue relationship: RO:0002473 CL:0008007 ! composed primarily of visceral muscle cell property_value: skos:prefLabel "visceral muscle tissue" xsd:string property_value: terms:contributor https://orcid.org/0000-0001-6677-8489 property_value: terms:date "2023-02-16T10:17:46Z" xsd:dateTime [Term] id: UBERON:8600006 name: visceral striated muscle tissue def: "A striated muscle tissue that is associated with soft internal organs (viscera)." [https://pressbooks.pub/rbtallitsch/chapter/chapter-6-muscle-tissue/, PMID:8720463] synonym: "striated visceral muscle tissue" EXACT [] is_a: UBERON:0002036 ! striated muscle tissue is_a: UBERON:8600004 ! visceral muscle tissue property_value: skos:prefLabel "visceral striated muscle tissue" xsd:string property_value: terms:contributor https://orcid.org/0000-0001-6677-8489 property_value: terms:date "2023-02-16T10:34:43Z" xsd:dateTime [Term] id: UBERON:8600010 name: bronchial submucosal gland ciliated duct def: "A ciliated duct part of a bronchial submucosal gland." [PMID:30864819] subset: human_reference_atlas is_a: UBERON:8600014 ! submucosal gland ciliated duct intersection_of: UBERON:8600014 ! submucosal gland ciliated duct intersection_of: BFO:0000050 UBERON:8410043 ! part of bronchus submucosal gland relationship: BFO:0000050 UBERON:8410043 ! part of bronchus submucosal gland property_value: RO:0002175 NCBITaxon:9606 property_value: terms:contributor https://orcid.org/0000-0001-6677-8489 property_value: terms:contributor https://orcid.org/0000-0002-9185-3994 property_value: terms:date "2023-05-02T08:07:56Z" xsd:dateTime [Term] id: UBERON:8600011 name: tracheal submucosal gland ciliated duct def: "A ciliated duct part of a tracheal submucosal gland." [PMID:30864819] subset: human_reference_atlas is_a: UBERON:8600014 ! submucosal gland ciliated duct intersection_of: UBERON:8600014 ! submucosal gland ciliated duct intersection_of: BFO:0000050 UBERON:0005203 ! part of trachea gland relationship: BFO:0000050 UBERON:0005203 ! part of trachea gland property_value: RO:0002175 NCBITaxon:9606 property_value: terms:contributor https://orcid.org/0000-0001-6677-8489 property_value: terms:contributor https://orcid.org/0000-0002-9185-3994 property_value: terms:date "2023-05-02T08:08:14Z" xsd:dateTime [Term] id: UBERON:8600012 name: submucosal gland acinus def: "A spherical or tubular structure in a submucosal gland that produces and secretes mucus and other substances into the ducts leading to the surface epithelium." [PMID:17394068, PMID:17707699, PMID:25648514, PMID:30864819] subset: human_reference_atlas is_a: UBERON:0014717 ! mucous acinus intersection_of: UBERON:0009842 ! glandular acinus intersection_of: BFO:0000050 UBERON:0011148 ! part of submucosal gland relationship: BFO:0000050 UBERON:0011148 ! part of submucosal gland property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "submucosal gland acinus" xsd:string property_value: terms:contributor https://orcid.org/0000-0001-6677-8489 property_value: terms:date "2023-05-02T08:57:27Z" xsd:dateTime [Term] id: UBERON:8600014 name: submucosal gland ciliated duct def: "A ciliated tubular structure in a submucosal gland connecting the submucosal gland collecting duct with the surface epithelium." [PMID:17707699, PMID:30864819] is_a: UBERON:0000058 ! duct relationship: BFO:0000050 UBERON:0011148 ! part of submucosal gland relationship: BFO:0000051 CL:0000067 ! has part ciliated epithelial cell property_value: terms:contributor https://orcid.org/0000-0001-6677-8489 property_value: terms:date "2023-05-02T08:09:14Z" xsd:dateTime [Term] id: UBERON:8600017 name: bronchopulmonary segment def: "A discrete anatomical unit of the lung that is composed of a segmental bronchus and the lung tissue supplied by that bronchus. A bronchopulmonary segment exhibits a pyramidal shape, with its apex pointing towards the center of the lung and its base toward the pleural surface." [doi:10.1016/j.mpaic.2008.09.022, FMA:7312, PMID:18271171, PMID:33620799] comment: A bronchopulmonary segment is surrounded by connective tissue septa, which are continuous with the pleural surface and prevent air collateralization between segments somewhat. In humans, the right lung has ten bronchopulmonary segments and eight or nine bronchopulmonary segments in the left lung. {xref="doi:10.1016/j.mpaic.2008.09.022", xref="PMID:18271171"} subset: human_reference_atlas synonym: "lung segment" EXACT [PMID:33620799] is_a: UBERON:0000063 ! organ subunit relationship: BFO:0000050 UBERON:0000101 ! part of lobe of lung relationship: RO:0002433 UBERON:0000101 ! contributes to morphology of lobe of lung property_value: RO:0002175 NCBITaxon:9606 property_value: skos:prefLabel "bronchopulmonary segment" xsd:string property_value: terms:contributor https://orcid.org/0000-0001-6677-8489 property_value: terms:contributor https://orcid.org/0000-0002-9185-3994 property_value: terms:date "2023-07-20T12:43:29Z" xsd:dateTime [Term] id: UBERON:8600018 name: neuroendocrine system def: "A regulatory system of the body that integrates the nervous system and the endocrine system. This system is formed by specialized neuroendocrine cells located mainly in the nervous system and neuroendocrine glands. However, they can also be found as either single cells or small clusters of cells dispersed throughout the surface epithelium of different tissues. The neuroendocrine system functions through the release of neurotransmitters and neurohormones, enabling communication between the endocrine and nervous systems to govern vitally important processes that include growth, reproduction, metabolism and energy homeostasis, electrolyte and water balance, and responses to stress." [doi:10.1016/B978-0-12-375097-6.10001-0, PMID:15481802, PMID:17003257, PMID:25905254, Wikipedia:endocrinology] comment: In vertebrates, the hypothalamic-pituitary-target organ axis (H-P axis), the autonomic nervous system (ANS) and the diffuse neuroendocrine or APUD system contribute to the neuroendocrine system. {xref="PMID:15481802"} synonym: "NES" RELATED OMO:0003000 [PMID:15481802] is_a: UBERON:0000467 ! anatomical system relationship: RO:0002131 UBERON:0000949 ! overlaps endocrine system relationship: RO:0002131 UBERON:0001016 ! overlaps nervous system property_value: skos:prefLabel "neuroendocrine system" xsd:string property_value: terms:contributor https://orcid.org/0000-0001-6677-8489 property_value: terms:date "2023-08-29T10:49:45Z" xsd:dateTime [Term] id: UBERON:8600021 name: chorionic plate blood vessel def: "A blood vessel that is part of the chorionic plate." [https://www.ncbi.nlm.nih.gov/books/NBK53254/] subset: human_reference_atlas is_a: UBERON:0022358 ! placenta blood vessel intersection_of: UBERON:0001981 ! blood vessel intersection_of: BFO:0000050 UBERON:0004027 ! part of chorionic plate relationship: BFO:0000050 UBERON:0004027 ! part of chorionic plate property_value: RO:0002175 NCBITaxon:9606 property_value: terms:contributor https://orcid.org/0000-0001-6677-8489 property_value: terms:date "2023-09-14T09:09:36Z" xsd:dateTime [Term] id: UBERON:8600023 name: placental villous stroma def: "A stroma that is part of a chorionic villus (placental villus). A placental villous stroma supports the fetal capillaries and villous trophoblast." [PMID:31512233] synonym: "chorionic villous stroma" EXACT [PMID:12624135] synonym: "CVS" RELATED OMO:0003000 [PMID:12624135] is_a: UBERON:0003891 ! stroma intersection_of: UBERON:0003891 ! stroma intersection_of: BFO:0000050 UBERON:0007106 ! part of chorionic villus relationship: BFO:0000050 UBERON:0007106 ! part of chorionic villus property_value: terms:contributor https://orcid.org/0000-0001-6677-8489 property_value: terms:contributor https://orcid.org/0000-0001-7655-4833 property_value: terms:date "2023-07-04T10:46:17Z" xsd:dateTime [Term] id: UBERON:8600024 name: pulmonary venule def: "A venule that is part of a lung and drains oxygenated blood from pulmonary capillaries. A pulmonary venule merges into a pulmonary vein branch that runs in the pulmonary interlobular septa." [PMID:22283705, PMID:30247823] is_a: UBERON:0003494 ! respiratory system venule is_a: UBERON:0003512 ! lung blood vessel intersection_of: UBERON:0001979 ! venule intersection_of: BFO:0000050 UBERON:0002048 ! part of lung relationship: BFO:0000050 UBERON:0013127 ! part of pulmonary venous system relationship: RO:0002170 UBERON:0002016 ! connected to pulmonary vein relationship: RO:0020102 UBERON:0016405 ! vessel drains blood from pulmonary capillary property_value: skos:prefLabel "pulmonary venule" xsd:string property_value: terms:contributor https://orcid.org/0000-0001-6677-8489 property_value: terms:date "2023-10-24T11:26:27Z" xsd:dateTime [Term] id: UBERON:8600034 name: jejunum lamina propria def: "A lamina propria that is part of a jejunum." [PMID:9394954] synonym: "jejunal lamina propria" EXACT [PMID:1556433] synonym: "lamina propria of jejunum" EXACT [PMID:22763879] is_a: UBERON:0001238 ! lamina propria of small intestine intersection_of: UBERON:0000030 ! lamina propria intersection_of: BFO:0000050 UBERON:0002115 ! part of jejunum relationship: BFO:0000050 UBERON:0008343 ! part of intestinal villus of jejunum property_value: terms:contributor https://orcid.org/0000-0001-6677-8489 property_value: terms:contributor https://orcid.org/0000-0001-8134-3037 property_value: terms:date "2024-01-09T16:36:35Z" xsd:dateTime [Term] id: UBERON:8600035 name: ileum lamina propria def: "A lamina propria that is part of an ileum." [PMID:29316348] synonym: "ileal lamina propria" EXACT [PMID:37467267] synonym: "lamina propria of ileum" EXACT [PMID:36067905] is_a: UBERON:0001238 ! lamina propria of small intestine intersection_of: UBERON:0000030 ! lamina propria intersection_of: BFO:0000050 UBERON:0002116 ! part of ileum relationship: BFO:0000050 UBERON:0008344 ! part of intestinal villus of ileum property_value: terms:contributor https://orcid.org/0000-0001-6677-8489 property_value: terms:contributor https://orcid.org/0000-0001-8134-3037 property_value: terms:date "2024-01-09T16:48:17Z" xsd:dateTime [Term] id: UBERON:8600038 name: placental disc def: "A disc-shaped structure that is part of the placenta. A placental disc supports fetal development through the exchange of nutrients between maternal and fetal bloodstreams. The placental disc is structured to keep the blood streams separate, while maximizing surface area for the transport of nutrients between them, to maintain an immunological barrier." [PMID:35496035] subset: human_reference_atlas synonym: "placental disk" EXACT [PMID:30133439] is_a: UBERON:0000061 ! anatomical structure relationship: BFO:0000050 UBERON:0001987 ! part of placenta property_value: RO:0002175 NCBITaxon:9606 property_value: terms:contributor https://orcid.org/0000-0001-6677-8489 property_value: terms:date "2024-01-16T17:50:20Z" xsd:dateTime [Term] id: UBERON:8600039 name: chorionic villous mesenchyme def: "A mesenchyme that is part of a chorionic villus." [doi:10.1007/978-3-030-84725-8] subset: human_reference_atlas is_a: UBERON:0002050 ! embryonic structure is_a: UBERON:0003265 ! chorionic mesenchyme is_a: UBERON:0005291 ! embryonic tissue intersection_of: UBERON:0003104 ! mesenchyme intersection_of: BFO:0000050 UBERON:0007106 ! part of chorionic villus relationship: BFO:0000050 UBERON:0007106 ! part of chorionic villus property_value: RO:0002175 NCBITaxon:9606 property_value: terms:contributor https://orcid.org/0000-0001-6677-8489 property_value: terms:date "2024-01-16T18:13:12Z" xsd:dateTime [Term] id: UBERON:8600042 name: endometrial lymphatic vessel def: "A lymphatic vessel that is part of an endometrium." [PMID:23054374] subset: human_reference_atlas is_a: UBERON:0001473 ! lymphatic vessel is_a: UBERON:0005156 ! reproductive structure intersection_of: UBERON:0001473 ! lymphatic vessel intersection_of: BFO:0000050 UBERON:0001295 ! part of endometrium relationship: BFO:0000050 UBERON:0001295 ! part of endometrium property_value: RO:0002175 NCBITaxon:9606 property_value: terms:contributor https://orcid.org/0000-0001-6677-8489 property_value: terms:date "2024-01-16T18:18:36Z" xsd:dateTime [Term] id: UBERON:8600118 name: myenteric ganglion def: "A ganglion that is part of a myenteric plexus. The myoenteric ganglion serves as a control center for local gut functions, such as motility." [ILX:0793734, PMID:31855386] synonym: "myenteric plexus ganglion" EXACT [ILX:0793735] xref: ILX:0793734 is_a: UBERON:0001805 ! autonomic ganglion intersection_of: UBERON:0000045 ! ganglion intersection_of: BFO:0000050 UBERON:0002439 ! part of myenteric nerve plexus relationship: BFO:0000050 UBERON:0002439 ! part of myenteric nerve plexus property_value: terms:contributor https://orcid.org/0000-0001-6677-8489 property_value: terms:date "2025-02-13T17:17:15Z" xsd:dateTime [Term] id: UBERON:8600119 name: myenteric ganglion of small intestine def: "A myenteric ganglion located in the myenteric plexus of the small intestine." [ILX:0793735] xref: ILX:0793735 is_a: UBERON:8600118 ! myenteric ganglion intersection_of: UBERON:8600118 ! myenteric ganglion intersection_of: BFO:0000050 UBERON:0002108 ! part of small intestine relationship: BFO:0000050 UBERON:0002108 ! part of small intestine property_value: terms:contributor https://orcid.org/0000-0001-6677-8489 property_value: terms:date "2025-02-13T17:20:16Z" xsd:dateTime [Term] id: UBERON:8600120 name: atrial intrinsic cardiac ganglion def: "A ganglion that is part of the atrial region of the heart. The activation of efferent neurons in this ganglion results in the modulation of heart rate, atrio-ventricular node conduction, and inotropism of atria and ventricles." [ILX:0793555, PMID:23559611, PMID:33255284] synonym: "atrial ganglionated plexus" RELATED [ILX:0793555] xref: ILX:0793555 is_a: UBERON:0007134 ! trunk ganglion is_a: UBERON:0014463 ! cardiac ganglion intersection_of: UBERON:0014463 ! cardiac ganglion intersection_of: BFO:0000050 UBERON:0002081 ! part of cardiac atrium relationship: BFO:0000050 UBERON:0002081 ! part of cardiac atrium property_value: terms:contributor https://orcid.org/0000-0001-6677-8489 property_value: terms:date "2025-02-13T17:23:00Z" xsd:dateTime [Term] id: UBERON:8600121 name: lumbar ganglion def: "A ganglion that is part of the lumbar portion of the sympathetic trunk. The neurons in a lumbar ganglion are postganglionic sympathetic neurons that synapse with axons from preganglionic sympathetic neurons." [https://www.elsevier.com/resources/anatomy/nervous-system/peripheral-nervous-system/lumbar-ganglia/23245, PMID:30969736, PMID:33085353, wikipediaversioned:Lumbar_ganglia&oldid=1023349088] comment: In humans there are four lumbar ganglia and they are positioned anterolateral to the lumbar vertebrae and deep to the psoas major muscle. {xref="PMID:30969736", xref="wikipediaversioned:Lumbar_ganglia&oldid=1023349088"} synonym: "lumbar paravertebral ganglion" EXACT [FMA:6472] synonym: "lumbar sympathetic ganglion" EXACT [FMA:6472] xref: FMA:6472 is_a: UBERON:0001807 ! paravertebral ganglion is_a: UBERON:0009758 ! abdominal ganglion relationship: BFO:0000050 UBERON:0005462 ! part of lower back property_value: terms:contributor https://orcid.org/0000-0001-6677-8489 property_value: terms:date "2025-02-13T17:25:41Z" xsd:dateTime [Term] id: UBERON:8600122 name: sacral ganglion def: "A ganglion that is part of the sacral portion of the sympathetic trunk. A sacral ganglion consists of postganglionic sympathetic neurons that receive presynaptic input from preganglionic sympathetic axons descending through the sympathetic trunk from thoracolumbar levels." [FMA:6473, https://www.elsevier.com/resources/anatomy/nervous-system/peripheral-nervous-system/sacral-ganglia/24872, PMID:33085353, wikipediaversioned:Sacral_ganglia&oldid=1222899024] synonym: "sacral sympathetic ganglion" EXACT [FMA:6473] xref: FMA:6473 is_a: UBERON:0001807 ! paravertebral ganglion is_a: UBERON:0009758 ! abdominal ganglion intersection_of: UBERON:0001807 ! paravertebral ganglion intersection_of: BFO:0000050 UBERON:0005473 ! part of sacral region relationship: BFO:0000050 UBERON:0005473 ! part of sacral region property_value: terms:contributor https://orcid.org/0000-0001-6677-8489 property_value: terms:date "2025-02-24T14:04:14Z" xsd:dateTime [Term] id: UBERON:8600123 name: lower airway ganglion def: "A parasympathetic ganglion that is located within the airway walls of the lower respiratory tract. This ganglion is responsible for controlling the constriction of the airway by stimulating smooth muscle contraction in the lower respiratory tract to regulate airflow." [doi:10.1016/B978-008045046-9.00635-5, ILX:0793573, PMID:35965034] synonym: "lower airway parasympathetic ganglion" EXACT [ILX:0793573] xref: ILX:0793573 is_a: UBERON:0001808 ! parasympathetic ganglion intersection_of: UBERON:0001808 ! parasympathetic ganglion intersection_of: BFO:0000050 UBERON:0001558 ! part of lower respiratory tract relationship: BFO:0000050 UBERON:0001558 ! part of lower respiratory tract property_value: skos:prefLabel "lower airway ganglion" xsd:string property_value: terms:contributor https://orcid.org/0000-0001-6677-8489 property_value: terms:date "2025-02-24T14:15:29Z" xsd:dateTime [Term] id: UBERON:8600124 name: fallopian tube epithelium def: "A simple columnar epithelium that is part of the fallopian tube." [PMID:7714136, Wikipedia:Fallopian_tube] is_a: UBERON:0004804 ! oviduct epithelium is_a: UBERON:0012274 ! columnar epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: BFO:0000050 UBERON:0003889 ! part of fallopian tube relationship: BFO:0000050 UBERON:0003889 ! part of fallopian tube property_value: terms:contributor https://orcid.org/0000-0001-6677-8489 property_value: terms:contributor https://orcid.org/0000-0001-7655-4833 property_value: terms:date "2025-03-04T14:24:07Z" xsd:dateTime [Term] id: UBERON:8600134 name: ascending colon lamina propria def: "The lamina propria that underlies the epithelial lining of the ascending colon." [https://orcid.org/0000-0003-4389-9821] synonym: "ascending colonic lamina propria" EXACT [] synonym: "lamina propria of ascending colon" EXACT [] is_a: UBERON:0011189 ! lamina propria of large intestine intersection_of: UBERON:0000030 ! lamina propria intersection_of: BFO:0000050 UBERON:0001156 ! part of ascending colon relationship: BFO:0000050 UBERON:0001156 ! part of ascending colon property_value: terms:contributor https://orcid.org/0000-0002-7073-9172 property_value: terms:date "2025-05-27T17:07:22Z" xsd:dateTime [Term] id: UBERON:8600135 name: descending colon lamina propria def: "The lamina propria that underlies the epithelial lining of the descending colon." [https://orcid.org/0000-0003-4389-9821] synonym: "descending colonic lamina propria" EXACT [] synonym: "lamina propria of descending colon" EXACT [] is_a: UBERON:0011189 ! lamina propria of large intestine intersection_of: UBERON:0000030 ! lamina propria intersection_of: BFO:0000050 UBERON:0001158 ! part of descending colon relationship: BFO:0000050 UBERON:0001158 ! part of descending colon property_value: terms:contributor https://orcid.org/0000-0002-7073-9172 property_value: terms:date "2025-05-27T17:07:22Z" xsd:dateTime [Term] id: UBERON:8600136 name: sigmoid colon lamina propria def: "The lamina propria that underlies the epithelial lining of the sigmoid colon." [https://orcid.org/0000-0003-4389-98219] synonym: "lamina propria of sigmoid colon" EXACT [] synonym: "sigmoid colonic lamina propria" EXACT [] is_a: UBERON:0011189 ! lamina propria of large intestine intersection_of: UBERON:0000030 ! lamina propria intersection_of: BFO:0000050 UBERON:0001159 ! part of sigmoid colon relationship: BFO:0000050 UBERON:0001159 ! part of sigmoid colon property_value: skos:prefLabel "sigmoid colon lamina propria" xsd:string property_value: terms:contributor https://orcid.org/0000-0002-7073-9172 property_value: terms:date "2025-05-27T17:07:22Z" xsd:dateTime [Term] id: UBERON:8600137 name: transverse colon lamina propria def: "The lamina propria that underlies the epithelial lining of the transverse colon." [https://orcid.org/0000-0003-4389-9821] synonym: "lamina propria of transverse colon" EXACT [] synonym: "transverse colonic lamina propria" EXACT [] is_a: UBERON:0011189 ! lamina propria of large intestine intersection_of: UBERON:0000030 ! lamina propria intersection_of: BFO:0000050 UBERON:0001157 ! part of transverse colon relationship: BFO:0000050 UBERON:0001157 ! part of transverse colon property_value: terms:contributor https://orcid.org/0000-0002-7073-9172 property_value: terms:date "2025-05-27T17:07:22Z" xsd:dateTime [Term] id: UBERON:8600138 name: stomach lamina propria def: "The lamina propria that underlies the epithelial lining of the stomach." [https://orcid.org/0000-0003-4389-9821] synonym: "gastric lamina propria" EXACT [] synonym: "lamina propria of stomach" EXACT [] is_a: UBERON:0004780 ! gastrointestinal system lamina propria intersection_of: UBERON:0000030 ! lamina propria intersection_of: BFO:0000050 UBERON:0000945 ! part of stomach relationship: BFO:0000050 UBERON:0000945 ! part of stomach property_value: skos:prefLabel "stomach lamina propria" xsd:string property_value: terms:contributor https://orcid.org/0000-0002-7073-9172 property_value: terms:date "2025-05-27T17:07:22Z" xsd:dateTime [Term] id: UBERON:8600139 name: caecum lamina propria def: "The lamina propria that underlies the epithelial lining of the caecum." [https://orcid.org/0000-0003-4389-9821] synonym: "cecal lamina propria" EXACT [] synonym: "cecum lamina propria" EXACT [] synonym: "lamina propria of caecum" EXACT [] synonym: "lamina propria of cecum" EXACT [] is_a: UBERON:0011189 ! lamina propria of large intestine intersection_of: UBERON:0000030 ! lamina propria intersection_of: BFO:0000050 UBERON:0001153 ! part of caecum relationship: BFO:0000050 UBERON:0001153 ! part of caecum property_value: terms:contributor https://orcid.org/0000-0002-7073-9172 property_value: terms:date "2025-05-27T17:07:22Z" xsd:dateTime [Term] id: UBERON:8600140 name: rectum lamina propria def: "The lamina propria that underlies the epithelial lining of the rectum." [https://orcid.org/0000-0003-4389-9821] synonym: "lamina propria of rectum" EXACT [] synonym: "rectal lamina propria" EXACT [] is_a: UBERON:0011189 ! lamina propria of large intestine intersection_of: UBERON:0000030 ! lamina propria intersection_of: BFO:0000050 UBERON:0001052 ! part of rectum relationship: BFO:0000050 UBERON:0001052 ! part of rectum property_value: skos:prefLabel "rectum lamina propria" xsd:string property_value: terms:contributor https://orcid.org/0000-0002-7073-9172 property_value: terms:date "2025-05-27T17:07:22Z" xsd:dateTime [Term] id: UBERON:8600148 name: tooth surface structure def: "A surface structure that is part of a calcareous tooth." [PMID:32491475] synonym: "tooth surface" EXACT [PMID:32071532] is_a: UBERON:0003102 ! surface structure intersection_of: UBERON:0003102 ! surface structure intersection_of: BFO:0000050 UBERON:0001091 ! part of calcareous tooth relationship: BFO:0000050 UBERON:0001091 ! part of calcareous tooth property_value: terms:contributor https://orcid.org/0000-0001-6677-8489 property_value: terms:date "2025-08-05T09:28:57Z" xsd:dateTime [Term] id: UBERON:8850000 name: lumen of pulmonary alveolus def: "An anatomical cavity that is part of the alveolus of the lung" [PMID:30390118] synonym: "alveolar lumen" BROAD [PMID:30390118] synonym: "cavity of pulmonary alveolus" EXACT [FMA:62779] synonym: "lumen of alveolus" BROAD [PMID:33806395] synonym: "pulmonary alveolar cavity" EXACT [FMA:62779] xref: FMA:62779 is_a: UBERON:0002553 ! anatomical cavity intersection_of: UBERON:0002553 ! anatomical cavity intersection_of: RO:0002572 UBERON:0002299 ! luminal space of alveolus of lung relationship: RO:0002572 UBERON:0002299 ! luminal space of alveolus of lung property_value: terms:contributor https://orcid.org/0009-0000-8480-9277 property_value: terms:date "2024-06-28T10:50:18Z" xsd:dateTime [Term] id: UBERON:8910000 name: stomatogastric nervous system def: "The part of the nervous system that controls the stomach, such as in crabs, lobsters, and flies" [DOI:10.1016/B0-12-370878-8/00177-4, FlyBase:FBrf0089570, PMID:12966498, PMID:27450880] is_a: UBERON:0011216 ! organ system subdivision relationship: RO:0002162 NCBITaxon:6656 ! in taxon Arthropoda property_value: terms:contributor https://orcid.org/0000-0002-1909-7004 [Term] id: UBERON:8910001 name: stomatogastric ganglion def: "The stomatogastric ganglion (STG) consists of about 30 neurons that form two central pattern generator circuits in crustaceans. STG neurons have large soma (~50-100 um) and have complex branches. The STG contains the motor neurons that innervate the striated muscles that move the gastric mill and pyloric regions of the stomach." [PMID:17009928] synonym: "STG" RELATED OMO:0003000 [PMID:17009928] is_a: UBERON:0011216 ! organ system subdivision relationship: BFO:0000050 UBERON:8910000 ! part of stomatogastric nervous system relationship: RO:0002162 NCBITaxon:6692 ! in taxon Pleocyemata property_value: terms:contributor https://orcid.org/0000-0002-1909-7004 [Term] id: http://identifiers.org/ensembl/ENSG00000006128 name: TAC1 is_a: SO:0000704 [Term] id: http://identifiers.org/ensembl/ENSG00000010327 name: STAB1 is_a: SO:0000704 [Term] id: http://identifiers.org/ensembl/ENSG00000038295 name: TLL1 is_a: SO:0000704 [Term] id: http://identifiers.org/ensembl/ENSG00000038945 name: MSR1 is_a: SO:0000704 [Term] id: http://identifiers.org/ensembl/ENSG00000041982 name: TNC is_a: SO:0000704 [Term] id: http://identifiers.org/ensembl/ENSG00000047648 name: ARHGAP6 is_a: SO:0000704 [Term] id: http://identifiers.org/ensembl/ENSG00000047936 name: ROS1 is_a: SO:0000704 [Term] id: http://identifiers.org/ensembl/ENSG00000050730 name: TNIP3 is_a: SO:0000704 [Term] id: http://identifiers.org/ensembl/ENSG00000051128 name: HOMER3 is_a: SO:0000704 [Term] id: http://identifiers.org/ensembl/ENSG00000053747 name: LAMA3 is_a: SO:0000704 [Term] id: http://identifiers.org/ensembl/ENSG00000072694 name: FCGR2B is_a: SO:0000704 [Term] id: http://identifiers.org/ensembl/ENSG00000078898 name: BPIFB2 is_a: SO:0000704 [Term] id: http://identifiers.org/ensembl/ENSG00000079691 name: CARMIL1 is_a: SO:0000704 [Term] id: http://identifiers.org/ensembl/ENSG00000082293 name: COL19A1 is_a: SO:0000704 [Term] id: http://identifiers.org/ensembl/ENSG00000082482 name: KCNK2 is_a: SO:0000704 [Term] id: http://identifiers.org/ensembl/ENSG00000082684 name: SEMA5B is_a: SO:0000704 [Term] id: http://identifiers.org/ensembl/ENSG00000100292 name: HMOX1 is_a: SO:0000704 [Term] id: http://identifiers.org/ensembl/ENSG00000100362 name: PVALB is_a: SO:0000704 [Term] id: http://identifiers.org/ensembl/ENSG00000100604 name: CHGA is_a: SO:0000704 [Term] id: http://identifiers.org/ensembl/ENSG00000101134 name: DOK5 is_a: SO:0000704 [Term] id: http://identifiers.org/ensembl/ENSG00000107796 name: ACTA2 is_a: SO:0000704 [Term] id: http://identifiers.org/ensembl/ENSG00000111215 name: PRR4 is_a: SO:0000704 [Term] id: http://identifiers.org/ensembl/ENSG00000113532 name: ST8SIA4 is_a: SO:0000704 [Term] id: http://identifiers.org/ensembl/ENSG00000114805 name: PLCH1 is_a: SO:0000704 [Term] id: http://identifiers.org/ensembl/ENSG00000115593 name: SMYD1 is_a: SO:0000704 [Term] id: http://identifiers.org/ensembl/ENSG00000118513 name: MYB is_a: SO:0000704 [Term] id: http://identifiers.org/ensembl/ENSG00000118523 name: CCN2 is_a: SO:0000704 [Term] id: http://identifiers.org/ensembl/ENSG00000119547 name: ONECUT2 is_a: SO:0000704 [Term] id: http://identifiers.org/ensembl/ENSG00000122585 name: NPY is_a: SO:0000704 [Term] id: http://identifiers.org/ensembl/ENSG00000122852 name: SFTPA1 is_a: SO:0000704 [Term] id: http://identifiers.org/ensembl/ENSG00000124302 name: CHST8 is_a: SO:0000704 [Term] id: http://identifiers.org/ensembl/ENSG00000124491 name: F13A1 is_a: SO:0000704 [Term] id: http://identifiers.org/ensembl/ENSG00000125869 name: LAMP5 is_a: SO:0000704 [Term] id: http://identifiers.org/ensembl/ENSG00000128536 name: CDHR3 is_a: SO:0000704 [Term] id: http://identifiers.org/ensembl/ENSG00000131097 name: HIGD1B is_a: SO:0000704 [Term] id: http://identifiers.org/ensembl/ENSG00000131471 name: AOC3 is_a: SO:0000704 [Term] id: http://identifiers.org/ensembl/ENSG00000131747 name: TOP2A is_a: SO:0000704 [Term] id: http://identifiers.org/ensembl/ENSG00000134138 name: MEIS2 is_a: SO:0000704 [Term] id: http://identifiers.org/ensembl/ENSG00000134443 name: GRP is_a: SO:0000704 [Term] id: http://identifiers.org/ensembl/ENSG00000137252 name: HCRTR2 is_a: SO:0000704 [Term] id: http://identifiers.org/ensembl/ENSG00000137573 name: SULF1 is_a: SO:0000704 [Term] id: http://identifiers.org/ensembl/ENSG00000137709 name: POU2F3 is_a: SO:0000704 [Term] id: http://identifiers.org/ensembl/ENSG00000137804 name: NUSAP1 is_a: SO:0000704 [Term] id: http://identifiers.org/ensembl/ENSG00000139329 name: LUM is_a: SO:0000704 [Term] id: http://identifiers.org/ensembl/ENSG00000140538 name: NTRK3 is_a: SO:0000704 [Term] id: http://identifiers.org/ensembl/ENSG00000143171 name: RXRG is_a: SO:0000704 [Term] id: http://identifiers.org/ensembl/ENSG00000143196 name: DPT is_a: SO:0000704 [Term] id: http://identifiers.org/ensembl/ENSG00000144227 name: NXPH2 is_a: SO:0000704 [Term] id: http://identifiers.org/ensembl/ENSG00000144229 name: THSD7B is_a: SO:0000704 [Term] id: http://identifiers.org/ensembl/ENSG00000145730 name: PAM is_a: SO:0000704 [Term] id: http://identifiers.org/ensembl/ENSG00000146469 name: VIP is_a: SO:0000704 [Term] id: http://identifiers.org/ensembl/ENSG00000149591 name: TAGLN is_a: SO:0000704 [Term] id: http://identifiers.org/ensembl/ENSG00000152818 name: UTRN is_a: SO:0000704 [Term] id: http://identifiers.org/ensembl/ENSG00000154080 name: CHST9 is_a: SO:0000704 [Term] id: http://identifiers.org/ensembl/ENSG00000154102 name: C16orf74 is_a: SO:0000704 [Term] id: http://identifiers.org/ensembl/ENSG00000156395 name: SORCS3 is_a: SO:0000704 [Term] id: http://identifiers.org/ensembl/ENSG00000156689 name: GLYATL2 is_a: SO:0000704 [Term] id: http://identifiers.org/ensembl/ENSG00000157005 name: SST is_a: SO:0000704 [Term] id: http://identifiers.org/ensembl/ENSG00000157404 name: KIT is_a: SO:0000704 [Term] id: http://identifiers.org/ensembl/ENSG00000162399 name: BSND is_a: SO:0000704 [Term] id: http://identifiers.org/ensembl/ENSG00000163377 name: TAFA4 is_a: SO:0000704 [Term] id: http://identifiers.org/ensembl/ENSG00000163735 name: CXCL5 is_a: SO:0000704 [Term] id: http://identifiers.org/ensembl/ENSG00000164120 name: HPGD is_a: SO:0000704 [Term] id: http://identifiers.org/ensembl/ENSG00000164330 name: EBF1 is_a: SO:0000704 [Term] id: http://identifiers.org/ensembl/ENSG00000166803 name: PCLAF is_a: SO:0000704 [Term] id: http://identifiers.org/ensembl/ENSG00000166959 name: MS4A8 is_a: SO:0000704 [Term] id: http://identifiers.org/ensembl/ENSG00000167306 name: MYO5B is_a: SO:0000704 [Term] id: http://identifiers.org/ensembl/ENSG00000168079 name: SCARA5 is_a: SO:0000704 [Term] id: http://identifiers.org/ensembl/ENSG00000170323 name: FABP4 is_a: SO:0000704 [Term] id: http://identifiers.org/ensembl/ENSG00000171303 name: KCNK3 is_a: SO:0000704 [Term] id: http://identifiers.org/ensembl/ENSG00000171346 name: KRT15 is_a: SO:0000704 [Term] id: http://identifiers.org/ensembl/ENSG00000171587 name: DSCAM is_a: SO:0000704 [Term] id: http://identifiers.org/ensembl/ENSG00000171848 name: RRM2 is_a: SO:0000704 [Term] id: http://identifiers.org/ensembl/ENSG00000171951 name: SCG2 is_a: SO:0000704 [Term] id: http://identifiers.org/ensembl/ENSG00000172673 name: THEMIS is_a: SO:0000704 [Term] id: http://identifiers.org/ensembl/ENSG00000174501 name: ANKRD36C is_a: SO:0000704 [Term] id: http://identifiers.org/ensembl/ENSG00000174807 name: CD248 is_a: SO:0000704 [Term] id: http://identifiers.org/ensembl/ENSG00000174948 name: GPR149 is_a: SO:0000704 [Term] id: http://identifiers.org/ensembl/ENSG00000175063 name: UBE2C is_a: SO:0000704 [Term] id: http://identifiers.org/ensembl/ENSG00000175497 name: DPP10 is_a: SO:0000704 [Term] id: http://identifiers.org/ensembl/ENSG00000176009 name: ASCL3 is_a: SO:0000704 [Term] id: http://identifiers.org/ensembl/ENSG00000178031 name: ADAMTSL1 is_a: SO:0000704 [Term] id: http://identifiers.org/ensembl/ENSG00000178538 name: CA8 is_a: SO:0000704 [Term] id: http://identifiers.org/ensembl/ENSG00000178568 name: ERBB4 is_a: SO:0000704 [Term] id: http://identifiers.org/ensembl/ENSG00000179902 name: C1orf194 is_a: SO:0000704 [Term] id: http://identifiers.org/ensembl/ENSG00000180801 name: ARSJ is_a: SO:0000704 [Term] id: http://identifiers.org/ensembl/ENSG00000183662 name: TAFA1 is_a: SO:0000704 [Term] id: http://identifiers.org/ensembl/ENSG00000184005 name: ST6GALNAC3 is_a: SO:0000704 [Term] id: http://identifiers.org/ensembl/ENSG00000184530 name: C6orf58 is_a: SO:0000704 [Term] id: http://identifiers.org/ensembl/ENSG00000185668 name: POU3F1 is_a: SO:0000704 [Term] id: http://identifiers.org/ensembl/ENSG00000185942 name: NKAIN3 is_a: SO:0000704 [Term] id: http://identifiers.org/ensembl/ENSG00000187908 name: DMBT1 is_a: SO:0000704 [Term] id: http://identifiers.org/ensembl/ENSG00000189056 name: RELN is_a: SO:0000704 [Term] id: http://identifiers.org/ensembl/ENSG00000189058 name: APOD is_a: SO:0000704 [Term] id: http://identifiers.org/ensembl/ENSG00000196090 name: PTPRT is_a: SO:0000704 [Term] id: http://identifiers.org/ensembl/ENSG00000196569 name: LAMA2 is_a: SO:0000704 [Term] id: http://identifiers.org/ensembl/ENSG00000197085 name: NPSR1-AS1 is_a: SO:0000704 [Term] id: http://identifiers.org/ensembl/ENSG00000197353 name: LYPD2 is_a: SO:0000704 [Term] id: http://identifiers.org/ensembl/ENSG00000197943 name: PLCG2 is_a: SO:0000704 [Term] id: http://identifiers.org/ensembl/ENSG00000198691 name: ABCA4 is_a: SO:0000704 [Term] id: http://identifiers.org/ensembl/ENSG00000198901 name: PRC1 is_a: SO:0000704 [Term] id: http://identifiers.org/ensembl/ENSG00000198963 name: RORB is_a: SO:0000704 [Term] id: http://identifiers.org/ensembl/ENSG00000204262 name: COL5A2 is_a: SO:0000704 [Term] id: http://identifiers.org/ensembl/ENSG00000204305 name: AGER is_a: SO:0000704 [Term] id: http://identifiers.org/ensembl/ENSG00000206073 name: SERPINB4 is_a: SO:0000704 [Term] id: http://identifiers.org/ensembl/ENSG00000215182 name: MUC5AC is_a: SO:0000704 [Term] id: http://identifiers.org/ensembl/ENSG00000227681 name: AL033504.1 is_a: SO:0000704 [Term] id: http://identifiers.org/ensembl/ENSG00000235665 name: LINC00298 is_a: SO:0000704 [Term] id: http://identifiers.org/ensembl/ENSG00000242021 name: AC112493.1 is_a: SO:0000704 [Term] id: http://identifiers.org/ensembl/ENSG00000242265 name: PEG10 is_a: SO:0000704 [Term] id: http://identifiers.org/ensembl/ENSG00000243004 name: ENSG00000243004;AC005062.2;AC005062.1 is_a: SO:0000704 [Term] id: http://identifiers.org/ensembl/ENSG00000249803 name: AC112178.1 is_a: SO:0000704 [Term] id: http://identifiers.org/ensembl/ENSG00000250971 name: AC110772.2 is_a: SO:0000704 [Term] id: http://identifiers.org/ensembl/ENSG00000256193 name: LINC00507 is_a: SO:0000704 [Term] id: http://identifiers.org/ensembl/ENSG00000264630 name: PRKCA-AS1 is_a: SO:0000704 [Term] id: http://identifiers.org/ensembl/ENSG00000265485 name: LINC01915 is_a: SO:0000704 [Term] id: http://identifiers.org/ensembl/ENSG00000267109 name: AC011990.1 is_a: SO:0000704 [Term] id: http://identifiers.org/ensembl/ENSG00000271860 name: AL589740.1 is_a: SO:0000704 [Term] id: http://identifiers.org/ensembl/ENSG00000275443 name: AC012409.2 is_a: SO:0000704 [Term] id: http://identifiers.org/ensembl/ENSG00000278254 name: AC004852.2 is_a: SO:0000704 [Term] id: http://identifiers.org/ensembl/ENSMUSG00000109994 name: Gm45459 (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/100040736 name: Foxd2os (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/100042056 name: 9130019P16Rik (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/100043902 name: Six3os1 (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/100503592 name: A330076C08Rik (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/100504234 name: Ccdc170 (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/101100 name: Ttll3 (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/101772 name: Ano1 (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/102632457 name: Gm30524 (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/102635243 name: Gm32633 (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/102638227 name: Gm34838 (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/103978 name: Gpc5 (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/104010 name: Cdh22 (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/104174 name: Gldc (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/104245 name: Slc6a5 (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/104798 name: Sfta3-ps (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/10716 name: TBR1 is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/107376 name: E330013P04Rik (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/107626 name: Asmt (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/108000 name: Cenpf (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/108068 name: Grm2 (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/108069 name: Grm3 (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/108073 name: Grm7 (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/109272 name: Mybpc1 (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/109648 name: Npy (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/109979 name: Art3 (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/110648 name: Lmx1a (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/110862 name: Kcnq3 (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/11281 name: POU6F2 is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/114873 name: Dscaml1 (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/11540 name: Adora2a (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/11606 name: Agt (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/11668 name: Aldh1a1 (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/11682 name: Alk (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/116847 name: Prelp (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/116849 name: Iltifb (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/11815 name: Apod (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/11816 name: Apoe (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/11826 name: Aqp1 (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/11829 name: Aqp4 (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/118446 name: Gjc3 (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/12111 name: Bgn (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/12159 name: Bmp4 (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/12161 name: Bmp6 (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/12192 name: Zfp36l1 (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/12259 name: C1qa (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/12268 name: C4b (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/12290 name: Cacna1e (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/12322 name: Camk2a (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/12374 name: Casr (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/12424 name: Cck (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/12494 name: Cd38 (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/12550 name: Cdh1 (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/12615 name: Cenpa (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/12741 name: Cldn5 (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/12951 name: Crx (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/12971 name: Crym (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/13051 name: Cx3cr1 (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/1310 name: COL19A1 is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/131034 name: CPNE4 is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/13142 name: Dao (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/13176 name: Dcc (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/13195 name: Ddc (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/13199 name: Ddn (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/13371 name: Dio2 (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/13411 name: Dnah11 (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/13488 name: Drd1 (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/13609 name: S1pr1 (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/13618 name: Ednrb (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/13649 name: Egfr (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/13865 name: Nr2f1 (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/1395 name: CRHR2 is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/14013 name: Mecom (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/140919 name: Slc17a6 (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/14165 name: Fgf10 (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/14281 name: Fos (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/14360 name: Fyn (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/14399 name: Gabra6 (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/14400 name: Gabrb1 (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/14412 name: Slc6a13 (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/14415 name: Gad1 (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/14417 name: Gad2 (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/14432 name: Gap43 (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/14560 name: Gdf10 (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/14580 name: Gfap (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/14609 name: Gja1 (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/14652 name: Glp1r (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/14695 name: Gnb3 (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/14699 name: Gngt1 (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/14710 name: Gngt2 (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/14714 name: Gnrh1 (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/14724 name: Gp1bb (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/14765 name: Gpr50 (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/14799 name: Gria1 (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/14800 name: Gria2 (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/14803 name: Grid1 (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/14811 name: Grin2a (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/14812 name: Grin2b (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/14813 name: Grin2c (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/14870 name: Gstp1 (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/15186 name: Hdc (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/15221 name: Foxd3 (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/15228 name: Foxg1 (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/15364 name: Hmga2 (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/15478 name: Hs3st3a1 (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/15483 name: Hsd11b1 (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/16008 name: Igfbp2 (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/16011 name: Igfbp5 (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/16323 name: Inhba (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/16372 name: Irx2 (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/16426 name: Itih3 (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/16572 name: Kif5a (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/16590 name: Kit (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/16840 name: Cnmd (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/16870 name: Lhx2 (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/16956 name: Lpl (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/17068 name: Ly6d (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/170790 name: Mlc1 (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/171211 name: Edaradd (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/17132 name: Maf (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/171469 name: Gpr37l1 (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/17155 name: Man1a (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/17219 name: Mcm6 (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/17300 name: Foxc1 (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/17304 name: Mfge8 (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/17345 name: Mki67 (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/17441 name: Mog (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/17533 name: Mrc1 (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/17536 name: Meis2 (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/17926 name: Myoc (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/1812 name: DRD1 is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/1813 name: DRD2 is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/18133 name: Ccn3 (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/18417 name: Cldn11 (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/18424 name: Otx2 (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/18479 name: Pak1 (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/18488 name: Cntn3 (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/18504 name: Pax2 (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/18545 name: Pcp2 (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/18553 name: Pcsk6 (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/18588 name: Pde6g (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/18595 name: Pdgfra (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/18610 name: Pdyn (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/18755 name: Prkch (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/19049 name: Ppp1r1b (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/19051 name: Ppp1r17 (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/19144 name: Klk6 (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/19216 name: Ptger1 (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/19227 name: Pthlh (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/19263 name: Ptprb (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/19293 name: Pvalb (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/19734 name: Rgs16 (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/20200 name: S100a6 (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/20284 name: Scrg1 (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/20311 name: Cxcl5 (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/20315 name: Cxcl12 (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/20363 name: Selenop (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/20377 name: Sfrp1 (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/20378 name: Frzb (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/20440 name: St6gal1 (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/20491 name: Sla (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/20743 name: Sptbn2 (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/208613 name: Tmem212 (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/208898 name: Unc13c (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/208936 name: Adamts18 (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/20963 name: Syk (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/210530 name: P3h2 (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/212377 name: Mms22l (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/213435 name: Mylk3 (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/213783 name: Plekhg1 (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/21386 name: Tbx3 (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/21416 name: Tcf7l2 (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/21418 name: Tfap2a (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/21419 name: Tfap2b (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/214944 name: Mob3b (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/215378 name: Brinp3 (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/216227 name: Slc17a8 (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/216616 name: Efemp1 (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/216892 name: Spns2 (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/216961 name: Coro6 (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/218194 name: Phactr1 (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/21824 name: Thbd (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/21828 name: Thbs4 (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/218772 name: Rarb (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/21973 name: Top2a (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/21990 name: Tph1 (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/22139 name: Ttr (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/22283 name: Ush2a (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/223332 name: Ranbp3l (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/22348 name: Slc32a1 (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/223843 name: Dbx2 (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/223970 name: Rmi2 (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/224079 name: Atp13a4 (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/226115 name: Opalin (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/226250 name: Afap1l2 (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/227580 name: C1ql3 (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/22771 name: Zic1 (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/22774 name: Zic4 (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/228731 name: Nkx2-4 (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/230726 name: Rhbdl2 (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/231633 name: Tmem119 (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/232174 name: Cyp26b1 (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/232685 name: Lncpint (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/233537 name: Gdpd4 (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/234258 name: Neil3 (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/235130 name: Adamts15 (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/237979 name: Sdk2 (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/23829 name: C1ql1 (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/23876 name: Fbln5 (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/239337 name: Adamts12 (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/239405 name: Rspo2 (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/240479 name: Dipk1c (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/241159 name: Neu4 (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/24141 name: LAMP5 is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/241489 name: Pde11a (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/242253 name: Wdr63 (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/242425 name: Gabbr2 (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/242735 name: Lrrc38 (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/243369 name: Sspo (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/243937 name: Zfp536 (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/244954 name: Prss35 (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/245827 name: Fat2 (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/246049 name: Slc36a2 (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/2571 name: GAD1 is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/2572 name: GAD2 is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/26468 name: LHX6 is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/26558 name: Homer3 (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/26563 name: Ror1 (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/268527 name: Greb1 (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/268709 name: Fam107a (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/268780 name: Egflam (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/268816 name: Mroh5 (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/269019 name: Stk32a (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/269275 name: Acvr1c (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/269629 name: Lhfpl3 (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/26968 name: Islr (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/270150 name: Ccdc153 (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/27086 name: FOXP1 is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/27428 name: Shroom3 (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/276952 name: Rasl10b (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/277468 name: Slc39a12 (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/278304 name: Zfp385c (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/2893 name: GRIA4 is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/2897 name: GRIK1 is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/29091 name: STXBP6 is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/30820 name: KCNIP1 is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/30952 name: Cngb3 (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/319903 name: 9630013A20Rik (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/319922 name: Vwc2 (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/319951 name: A230001M10Rik (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/319984 name: Jph4 (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/320772 name: Mdga2 (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/320784 name: C230072F16Rik (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/320981 name: Enpp6 (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/328354 name: Gm5087 (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/329078 name: Emx2os (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/329274 name: Fam163a (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/333564 name: Fndc3c1 (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/338521 name: Fa2h (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/3736 name: KCNA1 is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/373864 name: Col27a1 (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/381112 name: Arhgef33 (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/381925 name: Plpp4 (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/384071 name: Slc25a34 (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/395 name: ARHGAP6 is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/407831 name: Tmem204 (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/4212 name: MEIS2 is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/433022 name: Plcxd2 (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/4852 name: NPY is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/4861 name: NPAS1 is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/4929 name: NR4A2 is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/50768 name: Dlc1 (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/50779 name: Rgs6 (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/5079 name: PAX5 is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/50914 name: Olig1 (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/50929 name: Il22 (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/51797 name: Ctps (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/53896 name: Slc7a10 (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/54216 name: Pcdh7 (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/54612 name: Sfrp5 (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/54796 name: BNC2 is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/55553 name: SOX6 is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/56213 name: Htra1 (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/56410 name: Cbln3 (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/56744 name: Pf4 (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/56747 name: Sez6l (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/57084 name: SLC17A6 is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/57265 name: Fzd2 (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/5744 name: PTHLH is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/574402 name: Gpr17 (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/57915 name: Tbc1d1 (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/5816 name: PVALB is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/58187 name: Cldn10 (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/58222 name: Rab37 (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/58807 name: Slco1c1 (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/59058 name: Bhlhe22 (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/620376 name: Gm6145 (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/624549 name: Gm29683 (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/626082 name: Gm20754 (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/629147 name: Ctxn3 (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/63830 name: Kcnq1ot1 (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/64085 name: Clstn2 (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/64919 name: BCL11B is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/6496 name: SIX3 is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/6531 name: SLC6A3 is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/65969 name: Cubn (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/66214 name: Rgcc (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/66240 name: Kcne1l (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/66270 name: Retreg1 (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/66353 name: Riiad1 (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/66402 name: Sln (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/66425 name: Pcp4l1 (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/665119 name: Sec14l5 (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/66540 name: Fam107b (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/66673 name: Sorcs3 (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/667742 name: Piezo2 (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/66905 name: Plin3 (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/66977 name: Nuf2 (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/67473 name: Slc47a1 (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/6752 name: SSTR2 is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/67701 name: Wfdc2 (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/67791 name: 6530411M01Rik (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/67801 name: Pllp (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/67844 name: Rab32 (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/68026 name: Pclaf (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/68070 name: Pdzd2 (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/68178 name: Cgnl1 (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/68458 name: Ppp1r14a (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/68743 name: Anln (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/69239 name: Pdzph1 (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/70134 name: 2210011C24Rik (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/7054 name: TH is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/71481 name: Alpk1 (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/71660 name: Rarres2 (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/72258 name: Kcnk10 (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/72446 name: Prr5l (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/72555 name: Shisa9 (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/72893 name: 2900040C04Rik (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/72902 name: Spock3 (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/72927 name: Hepacam (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/72961 name: Slc17a7 (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/73940 name: Hapln2 (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/74145 name: F13a1 (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/74318 name: Hopx (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/7432 name: VIP is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/74563 name: Rasgef1c (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/75172 name: Ccdc146 (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/75396 name: Spp2 (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/75465 name: Dynlrb2 (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/75823 name: Fam227b (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/76088 name: Dock8 (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/76422 name: Mroh3 (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/76438 name: Rftn1 (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/76453 name: Prss23 (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/76747 name: Dapl1 (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/77018 name: Col25a1 (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/77125 name: Il33 (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/77808 name: Gm44196 (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/78748 name: Rassf10 (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/78754 name: Galnt15 (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/78896 name: Ecrg4 (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/793 name: CALB1 is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/80837 name: Rhoj (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/83430 name: Il23a (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/83453 name: Chrdl1 (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/83921 name: Cemip2 (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/93986 name: FOXP2 is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/9547 name: CXCL14 is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/96875 name: Prg4 (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/9705 name: ST18 is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/98267 name: Stk17b (Mmus) is_a: SO:0000704 [Term] id: http://identifiers.org/ncbigene/98363 name: Efhd1 (Mmus) is_a: SO:0000704 [Term] id: http://purl.obolibrary.org/obo/D96882F1-8709-49AB-BCA9-772A67EA6C33 name: obsolete D96882F1-8709-49AB-BCA9-772A67EA6C33 comment: ID was moved to the CL namespace. Use CL:0017509. is_obsolete: true replaced_by: CL:0017509 [Typedef] id: BFO:0000050 name: part of def: "a core relation that holds between a part and its whole" [] subset: http://purl.obolibrary.org/obo/valid_for_go_annotation_extension subset: http://purl.obolibrary.org/obo/valid_for_go_gp2term subset: http://purl.obolibrary.org/obo/valid_for_go_ontology subset: http://purl.obolibrary.org/obo/valid_for_gocam property_value: IAO:0000116 "Everything is part of itself. Any part of any part of a thing is itself part of that thing. Two distinct things cannot be part of each other." xsd:string property_value: IAO:0000116 "Occurrents are not subject to change and so parthood between occurrents holds for all the times that the part exists. Many continuants are subject to change, so parthood between continuants will only hold at certain times, but this is difficult to specify in OWL. See http://purl.obolibrary.org/obo/ro/docs/temporal-semantics/" xsd:string property_value: IAO:0000116 "Parthood requires the part and the whole to have compatible classes: only an occurrent can be part of an occurrent; only a process can be part of a process; only a continuant can be part of a continuant; only an independent continuant can be part of an independent continuant; only an immaterial entity can be part of an immaterial entity; only a specifically dependent continuant can be part of a specifically dependent continuant; only a generically dependent continuant can be part of a generically dependent continuant. (This list is not exhaustive.)\n\nA continuant cannot be part of an occurrent: use 'participates in'. An occurrent cannot be part of a continuant: use 'has participant'. A material entity cannot be part of an immaterial entity: use 'has location'. A specifically dependent continuant cannot be part of an independent continuant: use 'inheres in'. An independent continuant cannot be part of a specifically dependent continuant: use 'bearer of'." xsd:string property_value: seeAlso http://ontologydesignpatterns.org/wiki/Community:Parts_and_Collections property_value: seeAlso http://ontologydesignpatterns.org/wiki/Submissions:PartOf property_value: seeAlso "http://www.obofoundry.org/ro/#OBO_REL:part_of" xsd:string property_value: seeAlso "https://wiki.geneontology.org/Part_of" xsd:anyURI is_transitive: true is_a: RO:0002131 ! overlaps inverse_of: BFO:0000051 ! has part [Typedef] id: BFO:0000051 name: has part def: "a core relation that holds between a whole and its part" [] subset: http://purl.obolibrary.org/obo/valid_for_go_annotation_extension subset: http://purl.obolibrary.org/obo/valid_for_go_ontology subset: http://purl.obolibrary.org/obo/valid_for_gocam property_value: IAO:0000116 "Everything has itself as a part. Any part of any part of a thing is itself part of that thing. Two distinct things cannot have each other as a part." xsd:string property_value: IAO:0000116 "Occurrents are not subject to change and so parthood between occurrents holds for all the times that the part exists. Many continuants are subject to change, so parthood between continuants will only hold at certain times, but this is difficult to specify in OWL. See http://purl.obolibrary.org/obo/ro/docs/temporal-semantics/" xsd:string property_value: IAO:0000116 "Parthood requires the part and the whole to have compatible classes: only an occurrent have an occurrent as part; only a process can have a process as part; only a continuant can have a continuant as part; only an independent continuant can have an independent continuant as part; only a specifically dependent continuant can have a specifically dependent continuant as part; only a generically dependent continuant can have a generically dependent continuant as part. (This list is not exhaustive.)\n\nA continuant cannot have an occurrent as part: use 'participates in'. An occurrent cannot have a continuant as part: use 'has participant'. An immaterial entity cannot have a material entity as part: use 'location of'. An independent continuant cannot have a specifically dependent continuant as part: use 'bearer of'. A specifically dependent continuant cannot have an independent continuant as part: use 'inheres in'." xsd:string is_transitive: true is_a: RO:0002131 ! overlaps [Typedef] id: BFO:0000062 name: preceded by def: "x is preceded by y if and only if the time point at which y ends is before or equivalent to the time point at which x starts. Formally: x preceded by y iff ω(y) <= α(x), where α is a function that maps a process to a start point, and ω is a function that maps a process to an end point." [] subset: ro-eco property_value: IAO:0000116 "An example is: translation preceded_by transcription; aging preceded_by development (not however death preceded_by aging). Where derives_from links classes of continuants, preceded_by links classes of processes. Clearly, however, these two relations are not independent of each other. Thus if cells of type C1 derive_from cells of type C, then any cell division involving an instance of C1 in a given lineage is preceded_by cellular processes involving an instance of C. The assertion P preceded_by P1 tells us something about Ps in general: that is, it tells us something about what happened earlier, given what we know about what happened later. Thus it does not provide information pointing in the opposite direction, concerning instances of P1 in general; that is, that each is such as to be succeeded by some instance of P. Note that an assertion to the effect that P preceded_by P1 is rather weak; it tells us little about the relations between the underlying instances in virtue of which the preceded_by relation obtains. Typically we will be interested in stronger relations, for example in the relation immediately_preceded_by, or in relations which combine preceded_by with a condition to the effect that the corresponding instances of P and P1 share participants, or that their participants are connected by relations of derivation, or (as a first step along the road to a treatment of causality) that the one process in some way affects (for example, initiates or regulates) the other." xsd:string domain: BFO:0000003 range: BFO:0000003 holds_over_chain: BFO:0000050 BFO:0000062 is_transitive: true is_a: RO:0002086 ! ends after inverse_of: BFO:0000063 ! precedes [Typedef] id: BFO:0000063 name: precedes def: "x precedes y if and only if the time point at which x ends is before or equivalent to the time point at which y starts. Formally: x precedes y iff ω(x) <= α(y), where α is a function that maps a process to a start point, and ω is a function that maps a process to an end point." [] subset: ro-eco domain: BFO:0000003 range: BFO:0000003 holds_over_chain: BFO:0000050 BFO:0000063 is_transitive: true is_a: RO:0002222 ! temporally related to [Typedef] id: BFO:0000066 name: occurs in def: "b occurs_in c =def b is a process and c is a material entity or immaterial entity& there exists a spatiotemporal region r and b occupies_spatiotemporal_region r.& forall(t) if b exists_at t then c exists_at t & there exist spatial regions s and s’ where & b spatially_projects_onto s at t& c is occupies_spatial_region s’ at t& s is a proper_continuant_part_of s’ at t" [] comment: Paraphrase of definition: a relation between a process and an independent continuant, in which the process takes place entirely within the independent continuant subset: http://purl.obolibrary.org/obo/valid_for_go_annotation_extension subset: http://purl.obolibrary.org/obo/valid_for_go_ontology subset: http://purl.obolibrary.org/obo/valid_for_gocam property_value: seeAlso "https://wiki.geneontology.org/Occurs_in" xsd:anyURI domain: BFO:0000003 range: BFO:0000004 holds_over_chain: BFO:0000050 BFO:0000066 inverse_of: BFO:0000067 ! contains process transitive_over: BFO:0000050 ! part of [Typedef] id: BFO:0000067 name: contains process def: "[copied from inverse property 'occurs in'] b occurs_in c =def b is a process and c is a material entity or immaterial entity& there exists a spatiotemporal region r and b occupies_spatiotemporal_region r.& forall(t) if b exists_at t then c exists_at t & there exist spatial regions s and s’ where & b spatially_projects_onto s at t& c is occupies_spatial_region s’ at t& s is a proper_continuant_part_of s’ at t" [] comment: Paraphrase of definition: a relation between an independent continuant and a process, in which the process takes place entirely within the independent continuant [Typedef] id: CL:4030044 name: has_not_completed [Typedef] id: CL:4030045 name: lacks_part expand_expression_to: "http://purl.obolibrary.org/obo/BFO_0000051 exactly 0 ?Y" [] [Typedef] id: CL:4030046 name: lacks_plasma_membrane_part expand_expression_to: "http://purl.obolibrary.org/obo/BFO_0000051 exactly 0 (http://purl.obolibrary.org/obo/GO_0005886 and http://purl.obolibrary.org/obo/BFO_0000051 some ?Y)" [] [Typedef] id: RO:0000052 name: characteristic of def: "a relation between a specifically dependent continuant (the characteristic) and any other entity (the bearer), in which the characteristic depends on the bearer for its existence." [] comment: Note that this relation was previously called "inheres in", but was changed to be called "characteristic of" because BFO2 uses "inheres in" in a more restricted fashion. This relation differs from BFO2:inheres_in in two respects: (1) it does not impose a range constraint, and thus it allows qualities of processes, as well as of information entities, whereas BFO2 restricts inheres_in to only apply to independent continuants (2) it is declared functional, i.e. something can only be a characteristic of one thing. is_functional: true is_a: RO:0002314 ! characteristic of part of inverse_of: RO:0000053 ! has characteristic [Typedef] id: RO:0000053 name: has characteristic def: "Inverse of characteristic_of" [] property_value: IAO:0000116 "A bearer can have many dependents, and its dependents can exist for different periods of time, but none of its dependents can exist when the bearer does not exist." xsd:string range: BFO:0000020 is_inverse_functional: true [Typedef] id: RO:0000056 name: participates in def: "a relation between a continuant and a process, in which the continuant is somehow involved in the process" [] domain: BFO:0000002 range: BFO:0000003 inverse_of: has_participant ! has participant [Typedef] id: RO:0000080 name: quality of def: "a relation between a quality and an independent continuant (the bearer), in which the quality specifically depends on the bearer for its existence" [] comment: This relation is modeled after the BFO relation of the same name which was in BFO2, but is used in a more restricted sense - specifically, we model this relation as functional (inherited from characteristic-of). Note that this relation is now removed from BFO2020. property_value: IAO:0000116 "A quality inheres in its bearer at all times for which the quality exists." xsd:string is_a: RO:0000052 ! characteristic of inverse_of: RO:0000086 ! has quality [Typedef] id: RO:0000086 name: has quality def: "a relation between an independent continuant (the bearer) and a quality, in which the quality specifically depends on the bearer for its existence" [] property_value: IAO:0000116 "A bearer can have many qualities, and its qualities can exist for different periods of time, but none of its qualities can exist when the bearer does not exist." xsd:string range: BFO:0000019 is_a: RO:0000053 ! has characteristic [Typedef] id: RO:0001000 name: derives from def: "a relation between two distinct material entities, the new entity and the old entity, in which the new entity begins to exist when the old entity ceases to exist, and the new entity inherits the significant portion of the matter of the old entity" [] subset: ro-eco property_value: IAO:0000116 "This is a very general relation. More specific relations are preferred when applicable, such as 'directly develops from'." xsd:string inverse_of: RO:0001001 ! derives into [Typedef] id: RO:0001001 name: derives into def: "a relation between two distinct material entities, the old entity and the new entity, in which the new entity begins to exist when the old entity ceases to exist, and the new entity inherits the significant portion of the matter of the old entity" [] subset: ro-eco property_value: IAO:0000116 "This is a very general relation. More specific relations are preferred when applicable, such as 'directly develops into'. To avoid making statements about a future that may not come to pass, it is often better to use the backward-looking 'derives from' rather than the forward-looking 'derives into'." xsd:string [Typedef] id: RO:0001015 name: location of def: "a relation between two independent continuants, the location and the target, in which the target is entirely within the location" [] property_value: IAO:0000116 "Most location relations will only hold at certain times, but this is difficult to specify in OWL. See http://purl.obolibrary.org/obo/ro/docs/temporal-semantics/" xsd:string is_transitive: true inverse_of: RO:0001025 ! located in [Typedef] id: RO:0001025 name: located in def: "a relation between two independent continuants, the target and the location, in which the target is entirely within the location" [] subset: http://purl.obolibrary.org/obo/valid_for_go_gp2term property_value: IAO:0000116 "Location as a relation between instances: The primitive instance-level relation c located_in r at t reflects the fact that each continuant is at any given time associated with exactly one spatial region, namely its exact location. Following we can use this relation to define a further instance-level location relation - not between a continuant and the region which it exactly occupies, but rather between one continuant and another. c is located in c1, in this sense, whenever the spatial region occupied by c is part_of the spatial region occupied by c1. Note that this relation comprehends both the relation of exact location between one continuant and another which obtains when r and r1 are identical (for example, when a portion of fluid exactly fills a cavity), as well as those sorts of inexact location relations which obtain, for example, between brain and head or between ovum and uterus" xsd:string property_value: IAO:0000116 "Most location relations will only hold at certain times, but this is difficult to specify in OWL. See http://purl.obolibrary.org/obo/ro/docs/temporal-semantics/" xsd:string property_value: seeAlso "https://wiki.geneontology.org/Located_in" xsd:anyURI domain: BFO:0000004 {IAO:0000116="This is redundant with the more specific 'independent and not spatial region' constraint. We leave in the redundant axiom for use with reasoners that do not use negation."} range: BFO:0000004 {IAO:0000116="This is redundant with the more specific 'independent and not spatial region' constraint. We leave in the redundant axiom for use with reasoners that do not use negation."} is_transitive: true transitive_over: BFO:0000050 ! part of [Typedef] id: RO:0002000 name: 2D boundary of def: "a relation between a 2D immaterial entity (the boundary) and a material entity, in which the boundary delimits the material entity" [] property_value: IAO:0000116 "A 2D boundary may have holes and gaps, but it must be a single connected entity, not an aggregate of several disconnected parts." xsd:string property_value: IAO:0000116 "Although the boundary is two-dimensional, it exists in three-dimensional space and thus has a 3D shape." xsd:string is_a: RO:0002323 ! mereotopologically related to inverse_of: RO:0002002 ! has 2D boundary [Typedef] id: RO:0002002 name: has 2D boundary def: "a relation between a material entity and a 2D immaterial entity (the boundary), in which the boundary delimits the material entity" [] property_value: IAO:0000116 "A 2D boundary may have holes and gaps, but it must be a single connected entity, not an aggregate of several disconnected parts." xsd:string property_value: IAO:0000116 "Although the boundary is two-dimensional, it exists in three-dimensional space and thus has a 3D shape." xsd:string domain: BFO:0000040 range: BFO:0000141 is_a: RO:0002323 ! mereotopologically related to [Typedef] id: RO:0002005 name: innervated by def: "relation between an anatomical structure and a neuron projection bundle that has synaptic terminals in the structure." [] domain: UBERON:0000061 ! anatomical structure range: UBERON:0000122 ! neuron projection bundle inverse_of: RO:0002134 ! innervates transitive_over: RO:0002380 ! branching part of [Typedef] id: RO:0002006 name: has synaptic terminal of is_a: RO:0002131 ! overlaps inverse_of: RO:0002130 ! has synaptic terminal in [Typedef] id: RO:0002007 name: bounding layer of def: "X outer_layer_of Y iff:\n. X :continuant that bearer_of some PATO:laminar\n. X part_of Y\n. exists Z :surface\n. X has_boundary Z\n. Z boundary_of Y\n\nhas_boundary: http://purl.obolibrary.org/obo/RO_0002002\nboundary_of: http://purl.obolibrary.org/obo/RO_0002000" [] comment: A relationship that applies between a continuant and its outer, bounding layer. Examples include the relationship between a multicellular organism and its integument, between an animal cell and its plasma membrane, and between a membrane bound organelle and its outer/bounding membrane. subset: ro-eco range: BFO:0000040 is_a: BFO:0000050 ! part of [Typedef] id: RO:0002021 name: occurs across def: "A relationship between a process and a barrier, where the process occurs in a region spanning the barrier. For cellular processes the barrier is typically a membrane. Examples include transport across a membrane and membrane depolarization." [] is_a: RO:0002479 ! has part that occurs in creation_date: 2017-07-20T17:19:37Z [Typedef] id: RO:0002081 name: before or simultaneous with comment: Primitive instance level timing relation between events subset: ro-eco is_a: RO:0002222 ! temporally related to [Typedef] id: RO:0002082 name: simultaneous with def: "x simultaneous with y iff ω(x) = ω(y) and ω(α ) = ω(α), where α is a function that maps a process to a start point, and ω is a function that maps a process to an end point and '=' indicates the same instance in time." [] comment: t1 simultaneous_with t2 iff:= t1 before_or_simultaneous_with t2 and not (t1 before t2) subset: ro-eco is_symmetric: true is_transitive: true is_a: RO:0002081 ! before or simultaneous with [Typedef] id: RO:0002086 name: ends after comment: X ends_after Y iff: end(Y) before_or_simultaneous_with end(X) subset: ro-eco is_transitive: true is_a: RO:0002222 ! temporally related to [Typedef] id: RO:0002087 name: immediately preceded by comment: X immediately_preceded_by Y iff: end(X) simultaneous_with start(Y) holds_over_chain: RO:0002224 RO:0002230 is_a: BFO:0000062 ! preceded by inverse_of: RO:0002090 ! immediately precedes [Typedef] id: RO:0002090 name: immediately precedes comment: X immediately_precedes_Y iff: end(X) simultaneous_with start(Y) subset: ro-eco holds_over_chain: RO:0002230 RO:0002224 is_a: BFO:0000063 ! precedes [Typedef] id: RO:0002100 name: has soma location def: "Relation between a neuron and a material anatomical entity that its soma is part of." [] domain: CL:0000540 ! neuron range: UBERON:0000465 ! material anatomical entity is_a: RO:0002131 ! overlaps transitive_over: BFO:0000050 ! part of expand_expression_to: "BFO_0000051 some (\n GO_0043025 and BFO_0000050 some ?Y)" [] [Typedef] id: RO:0002101 name: fasciculates with def: "relationship between a neuron and a neuron projection bundle (e.g.- tract or nerve bundle) that one or more of its projections travels through.\n" [] domain: CL:0000540 ! neuron range: UBERON:0000122 ! neuron projection bundle is_a: RO:0002131 ! overlaps inverse_of: RO:0002132 ! has fasciculating neuron projection [Typedef] id: RO:0002102 name: axon synapses in def: "Relation between a neuron and some structure its axon forms (chemical) synapses in." [] domain: CL:0000540 ! neuron is_a: RO:0002113 ! has presynaptic terminal in transitive_over: BFO:0000050 ! part of expand_expression_to: "BFO_0000051 some (\n GO_0030424 and BFO_0000051 some (\n GO_0042734 and BFO_0000050 some (\n GO_0045202 and BFO_0000050 some ?Y)))" [] [Typedef] id: RO:0002103 name: synapsed by def: "Relation between an anatomical structure (including cells) and a neuron that chemically synapses to it. " [] is_a: RO:0002485 ! receives input from inverse_of: RO:0002120 ! synapsed to expand_expression_to: "BFO_0000051 some (GO_0045211 that part_of some (GO_0045202 that has_part some (GO_0042734 that BFO_0000050 some Y?)))" [] [Typedef] id: RO:0002104 name: has plasma membrane part def: "Holds between a cell c and a protein complex or protein p if and only if that cell has as part a plasma_membrane[GO:0005886], and that plasma membrane has p as part." [] domain: UBERON:0000465 ! material anatomical entity range: UBERON:0000465 ! material anatomical entity is_a: BFO:0000051 ! has part expand_expression_to: "BFO_0000051 some (GO_0005886 and BFO_0000051 some ?Y)" [] [Typedef] id: RO:0002110 name: has postsynaptic terminal in def: "Relation between a neuron and some structure (e.g.- a brain region) in which it receives (chemical) synaptic input. " [] domain: CL:0000540 ! neuron is_a: RO:0002130 ! has synaptic terminal in inverse_of: RO:0002113 ! has presynaptic terminal in transitive_over: BFO:0000050 ! part of expand_expression_to: "http://purl.obolibrary.org/obo/BFO_0000051 some (\n http://purl.org/obo/owl/GO#GO_0045211 and http://purl.obolibrary.org/obo/BFO_0000050 some (\n http://purl.org/obo/owl/GO#GO_0045202 and http://purl.obolibrary.org/obo/BFO_0000050 some ?Y))" [] [Typedef] id: RO:0002113 name: has presynaptic terminal in def: "Relation between a neuron and some structure (e.g.- a brain region) in which it receives (chemical) synaptic input." [] domain: CL:0000540 ! neuron is_a: RO:0002130 ! has synaptic terminal in transitive_over: BFO:0000050 ! part of expand_expression_to: "BFO_0000051 some (GO_0042734 that BFO_0000050 some (GO_0045202 that BFO_0000050 some Y?)" [] [Typedef] id: RO:0002120 name: synapsed to def: " Relation between a neuron and an anatomical structure (including cells) that it chemically synapses to.\n " [] comment: N1 synapsed_to some N2 \nExpands to:\nN1 SubclassOf ( \n has_part some (\n ‘pre-synaptic membrane ; GO:0042734’ that part_of some ( \n ‘synapse ; GO:0045202’ that has_part some (\n ‘post-synaptic membrane ; GO:0045211’ that part_of some N2)))) is_a: RO:0002486 ! sends output to expand_expression_to: "BFO_0000051 some (GO_0042734 that part_of some (GO_0045202 that BFO_0000051 some (GO_0045211 that BFO_0000050 some Y?)))" [] [Typedef] id: RO:0002130 name: has synaptic terminal in def: "A general relation between a neuron and some structure in which it either chemically synapses to some target or in which it receives (chemical) synaptic input." [] domain: CL:0000540 ! neuron is_a: RO:0002131 ! overlaps transitive_over: BFO:0000050 ! part of expand_expression_to: "RO_0002131 some (GO_0045202 that BFO_0000050 some Y?)" [] [Typedef] id: RO:0002131 name: overlaps def: "x overlaps y if and only if there exists some z such that x has part z and z part of y" [] subset: http://purl.obolibrary.org/obo/valid_for_go_annotation_extension subset: http://purl.obolibrary.org/obo/valid_for_gocam subset: ro-eco holds_over_chain: BFO:0000050 BFO:0000050 holds_over_chain: BFO:0000051 RO:0002131 is_symmetric: true is_a: RO:0002323 ! mereotopologically related to transitive_over: BFO:0000050 ! part of expand_expression_to: "http://purl.obolibrary.org/obo/BFO_0000051 some (http://purl.obolibrary.org/obo/BFO_0000050 some ?Y)" [] [Typedef] id: RO:0002132 name: has fasciculating neuron projection def: "The relation between a neuron projection bundle and a neuron projection that is fasciculated with it." [] domain: UBERON:0000122 ! neuron projection bundle is_a: RO:0002131 ! overlaps [Typedef] id: RO:0002134 name: innervates def: "Relation between a 'neuron projection bundle' and a region in which one or more of its component neuron projections either synapses to targets or receives synaptic input.\nT innervates some R\nExpands_to: T has_fasciculating_neuron_projection that synapse_in some R." [] domain: UBERON:0000122 ! neuron projection bundle transitive_over: BFO:0000050 ! part of expand_expression_to: "RO_0002132 some (GO_0043005 that (RO_0002131 some (GO_0045202 that BFO_0000050 some Y?)))" [] [Typedef] id: RO:0002150 name: continuous with def: "X continuous_with Y if and only if X and Y share a fiat boundary." [] property_value: seeAlso "FMA:85972" xsd:string domain: BFO:0000004 range: BFO:0000004 is_symmetric: true is_a: RO:0002323 ! mereotopologically related to [Typedef] id: RO:0002158 name: shares ancestor with def: "two individual entities d1 and d2 stand in a shares_ancestor_with relation if and only if there exists some a such that d1 derived_by_descent_from a and d2 derived_by_descent_from a." [] comment: VBO calls this homologous_to is_symmetric: true is_transitive: true is_a: RO:0002320 ! evolutionarily related to [Typedef] id: RO:0002160 name: only in taxon def: "x only in taxon y if and only if x is in taxon y, and there is no other organism z such that y!=z a and x is in taxon z." [] property_value: IAO:0000116 "The original intent was to treat this as a macro that expands to 'in taxon' only ?Y - however, this is not necessary if we instead have supplemental axioms that state that each pair of sibling tax have a disjointness axiom using the 'in taxon' property - e.g.\n\n 'in taxon' some Eukaryota DisjointWith 'in taxon' some Eubacteria" xsd:string property_value: seeAlso https://github.com/obophenotype/uberon/wiki/Taxon-constraints is_a: RO:0002162 ! in taxon [Typedef] id: RO:0002162 name: in taxon def: "x is in taxon y if an only if y is an organism, and the relationship between x and y is one of: part of (reflexive), developmentally preceded by, derives from, secreted by, expressed." [] comment: Connects a biological entity to its taxon of origin. subset: ro-eco synonym: "life cycle stage of" NARROW [] property_value: seeAlso https://github.com/obophenotype/uberon/wiki/Taxon-constraints holds_over_chain: RO:0002005 RO:0002162 holds_over_chain: RO:0002131 RO:0002162 holds_over_chain: RO:0002134 RO:0002162 holds_over_chain: RO:0002150 RO:0002162 holds_over_chain: RO:0002170 RO:0002162 holds_over_chain: RO:0002176 RO:0002162 holds_over_chain: RO:0002206 RO:0002162 holds_over_chain: RO:0002211 RO:0002162 holds_over_chain: RO:0002215 RO:0002162 holds_over_chain: RO:0002254 RO:0002162 holds_over_chain: RO:0002256 RO:0002162 holds_over_chain: RO:0002295 RO:0002162 holds_over_chain: RO:0002387 RO:0002162 holds_over_chain: RO:0002490 RO:0002162 holds_over_chain: RO:0003000 RO:0002162 holds_over_chain: RO:0003001 RO:0002162 is_a: RO:0002320 ! evolutionarily related to [Typedef] id: RO:0002163 name: spatially disjoint from def: "A is spatially_disjoint_from B if and only if they have no parts in common" [] subset: ro-eco property_value: IAO:0000116 "There are two ways to encode this as a shortcut relation. The other possibility to use an annotation assertion between two classes, and expand this to a disjointness axiom. " xsd:string property_value: seeAlso "https://github.com/obophenotype/uberon/wiki/Part-disjointness-Design-Pattern" xsd:anyURI is_a: RO:0002323 ! mereotopologically related to expand_expression_to: "BFO_0000051 exactly 0 (BFO_0000050 some ?Y)" [] [Typedef] id: RO:0002170 name: connected to def: "a is connected to b if and only if a and b are discrete structure, and there exists some connecting structure c, such that c connects a and b" [] property_value: seeAlso "https://github.com/obophenotype/uberon/wiki/Connectivity-Design-Pattern" xsd:anyURI property_value: seeAlso "https://github.com/obophenotype/uberon/wiki/Modeling-articulations-Design-Pattern" xsd:anyURI is_a: RO:0002323 ! mereotopologically related to [Typedef] id: RO:0002176 name: connects def: "c connects a if and only if there exist some b such that a and b are similar parts of the same system, and c connects b, specifically, c connects a with b. When one structure connects two others it unites some aspect of the function or role they play within the system." [] property_value: seeAlso "https://github.com/obophenotype/uberon/wiki/Connectivity-Design-Pattern" xsd:anyURI property_value: seeAlso "https://github.com/obophenotype/uberon/wiki/Modeling-articulations-Design-Pattern" xsd:anyURI domain: BFO:0000004 is_a: RO:0002323 ! mereotopologically related to [Typedef] id: RO:0002177 name: attached to part of def: "a is attached to part of b if a is attached to b, or a is attached to some p, where p is part of b." [] domain: UBERON:0000061 ! anatomical structure range: UBERON:0000061 ! anatomical structure is_a: RO:0002323 ! mereotopologically related to is_a: RO:0002567 ! biomechanically related to [Typedef] id: RO:0002178 name: supplies def: "Relation between an arterial structure and another structure, where the arterial structure acts as a conduit channeling fluid, substance or energy." [] property_value: IAO:0000116 "Individual ontologies should provide their own constraints on this abstract relation. For example, in the realm of anatomy this should hold between an artery and an anatomical structure" xsd:string is_a: RO:0002170 ! connected to [Typedef] id: RO:0002179 name: drains def: "Relation between an collecting structure and another structure, where the collecting structure acts as a conduit channeling fluid, substance or energy away from the other structure." [] property_value: IAO:0000116 "Individual ontologies should provide their own constraints on this abstract relation. For example, in the realm of anatomy this should hold between a vein and an anatomical structure" xsd:string is_a: RO:0002170 ! connected to [Typedef] id: RO:0002180 name: has component def: "w 'has component' p if w 'has part' p and w is such that it can be directly disassembled into into n parts p, p2, p3, ..., pn, where these parts are of similar type." [] subset: ro-eco property_value: IAO:0000116 "The definition of 'has component' is still under discussion. The challenge is in providing a definition that does not imply transitivity." xsd:string property_value: seeAlso http://ontologydesignpatterns.org/wiki/Submissions:Componency is_a: BFO:0000051 ! has part [Typedef] id: RO:0002202 name: develops from def: "x develops from y if and only if either (a) x directly develops from y or (b) there exists some z such that x directly develops from z and z develops from y" [] comment: This is the transitive form of the develops from relation domain: BFO:0000004 range: BFO:0000004 is_transitive: true is_a: RO:0002254 ! has developmental contribution from is_a: RO:0002258 ! developmentally preceded by inverse_of: RO:0002203 ! develops into [Typedef] id: RO:0002203 name: develops into def: "inverse of develops from" [] subset: RO:0002259 is_transitive: true is_a: RO:0002286 ! developmentally succeeded by is_a: RO:0002387 ! has potential to develop into is_a: RO:0002388 ! has potential to directly develop into [Typedef] id: RO:0002206 name: expressed in def: "x expressed in y if and only if there is a gene expression process (GO:0010467) that occurs in y, and one of the following holds: (i) x is a gene, and x is transcribed into a transcript as part of the gene expression process (ii) x is a transcript, and the transcription of x is part of the gene expression process (iii) x is a mature gene product such as a protein, and x was translated or otherwise processes from a transcript that was transcribed as part of this gene expression process" [] domain: BFO:0000002 range: UBERON:0000465 ! material anatomical entity is_a: RO:0002330 ! genomically related to inverse_of: RO:0002292 ! expresses transitive_over: BFO:0000050 ! part of [Typedef] id: RO:0002207 name: directly develops from def: "Candidate definition: x directly_develops from y if and only if there exists some developmental process (GO:0032502) p such that x and y both participate in p, and x is the output of p and y is the input of p, and a substantial portion of the matter of x comes from y, and the start of x is coincident with or after the end of y." [] comment: TODO - add child relations from DOS synonym: "has developmental precursor" EXACT [] is_a: RO:0002202 ! develops from inverse_of: RO:0002210 ! directly develops into [Typedef] id: RO:0002210 name: directly develops into def: "inverse of directly develops from" [] subset: RO:0002259 is_a: RO:0002203 ! develops into [Typedef] id: RO:0002211 name: regulates def: "p regulates q iff p is causally upstream of q, the execution of p is not constant and varies according to specific conditions, and p influences the rate or magnitude of execution of q due to an effect either on some enabler of q or some enabler of a part of q." [] subset: http://purl.obolibrary.org/obo/valid_for_go_annotation_extension subset: http://purl.obolibrary.org/obo/valid_for_go_ontology subset: http://purl.obolibrary.org/obo/valid_for_gocam domain: BFO:0000015 range: BFO:0000015 holds_over_chain: RO:0002230 RO:0002211 is_transitive: true is_a: RO:0002411 ! causally upstream of inverse_of: RO:0002334 ! regulated by [Typedef] id: RO:0002212 name: negatively regulates def: "p negatively regulates q iff p regulates q, and p decreases the rate or magnitude of execution of q." [] subset: http://purl.obolibrary.org/obo/valid_for_go_annotation_extension subset: http://purl.obolibrary.org/obo/valid_for_go_ontology subset: http://purl.obolibrary.org/obo/valid_for_gocam property_value: RO:0004050 RO:0002211 holds_over_chain: RO:0002230 RO:0002212 is_a: RO:0002211 ! regulates is_a: RO:0002305 ! causally upstream of, negative effect inverse_of: RO:0002335 ! negatively regulated by [Typedef] id: RO:0002213 name: positively regulates def: "p positively regulates q iff p regulates q, and p increases the rate or magnitude of execution of q." [] subset: http://purl.obolibrary.org/obo/valid_for_go_annotation_extension subset: http://purl.obolibrary.org/obo/valid_for_go_ontology subset: http://purl.obolibrary.org/obo/valid_for_gocam holds_over_chain: RO:0002212 RO:0002212 holds_over_chain: RO:0002230 RO:0002213 is_transitive: true is_a: RO:0002211 ! regulates is_a: RO:0002304 ! causally upstream of, positive effect inverse_of: RO:0002336 ! positively regulated by [Typedef] id: RO:0002215 name: capable of def: "A relation between a material entity (such as a cell) and a process, in which the material entity has the ability to carry out the process. " [] subset: ro-eco domain: BFO:0000004 range: BFO:0000015 is_a: RO:0002216 ! capable of part of [Typedef] id: RO:0002216 name: capable of part of def: "c stands in this relationship to p if and only if there exists some p' such that c is capable_of p', and p' is part_of p." [] property_value: seeAlso http://purl.obolibrary.org/obo/ro/docs/reflexivity/ is_a: RO:0002328 ! functionally related to is_a: RO:0002500 ! causal agent in process [Typedef] id: RO:0002219 name: surrounded by def: "x surrounded_by y if and only if (1) x is adjacent to y and for every region r that is adjacent to x, r overlaps y (2) the shared boundary between x and y occupies the majority of the outermost boundary of x" [] is_a: RO:0002220 ! adjacent to inverse_of: RO:0002221 ! surrounds [Typedef] id: RO:0002220 name: adjacent to def: "x adjacent to y if and only if x and y share a boundary." [] subset: http://purl.obolibrary.org/obo/valid_for_go_annotation_extension subset: http://purl.obolibrary.org/obo/valid_for_go_ontology subset: http://purl.obolibrary.org/obo/valid_for_gocam property_value: IAO:0000116 "This relation acts as a join point with BSPO" xsd:string domain: BFO:0000004 range: BFO:0000004 is_a: RO:0002163 ! spatially disjoint from [Typedef] id: RO:0002221 name: surrounds def: "inverse of surrounded by" [] subset: RO:0002259 is_a: RO:0002220 ! adjacent to [Typedef] id: RO:0002222 name: temporally related to comment: A relation that holds between two occurrents. This is a grouping relation that collects together all the Allen relations. subset: ro-eco domain: BFO:0000003 range: BFO:0000003 [Typedef] id: RO:0002223 name: starts def: "inverse of starts with" [] subset: ro-eco is_a: BFO:0000050 ! part of is_a: RO:0002222 ! temporally related to inverse_of: RO:0002224 ! starts with [Typedef] id: RO:0002224 name: starts with def: "x starts with y if and only if x has part y and the time point at which x starts is equivalent to the time point at which y starts. Formally: α(y) = α(x) ∧ ω(y) < ω(x), where α is a function that maps a process to a start point, and ω is a function that maps a process to an end point." [] subset: ro-eco is_transitive: true is_a: BFO:0000051 ! has part is_a: RO:0002222 ! temporally related to [Typedef] id: RO:0002225 name: develops from part of def: "x develops from part of y if and only if there exists some z such that x develops from z and z is part of y" [] holds_over_chain: RO:0002207 BFO:0000050 is_a: RO:0002202 ! develops from [Typedef] id: RO:0002226 name: develops in def: "x develops_in y if x is located in y whilst x is developing" [] domain: UBERON:0001062 ! anatomical entity holds_over_chain: RO:0002207 RO:0001025 is_a: RO:0002258 ! developmentally preceded by [Typedef] id: RO:0002229 name: ends def: "inverse of ends with" [] subset: ro-eco is_a: BFO:0000050 ! part of is_a: RO:0002222 ! temporally related to inverse_of: RO:0002230 ! ends with [Typedef] id: RO:0002230 name: ends with def: "x ends with y if and only if x has part y and the time point at which x ends is equivalent to the time point at which y ends. Formally: α(y) > α(x) ∧ ω(y) = ω(x), where α is a function that maps a process to a start point, and ω is a function that maps a process to an end point." [] subset: ro-eco is_transitive: true is_a: BFO:0000051 ! has part is_a: RO:0002222 ! temporally related to [Typedef] id: RO:0002231 name: has start location def: "x 'has starts location' y if and only if there exists some process z such that x 'starts with' z and z 'occurs in' y" [] subset: ro-eco domain: BFO:0000015 range: BFO:0000004 holds_over_chain: RO:0002224 BFO:0000066 is_a: RO:0002479 ! has part that occurs in [Typedef] id: RO:0002232 name: has end location def: "x 'has end location' y if and only if there exists some process z such that x 'ends with' z and z 'occurs in' y" [] subset: ro-eco domain: BFO:0000015 range: BFO:0000004 holds_over_chain: RO:0002230 BFO:0000066 is_a: RO:0002479 ! has part that occurs in [Typedef] id: RO:0002233 name: has input def: "p has input c iff: p is a process, c is a material entity, c is a participant in p, c is present at the start of p, and the state of c is modified during p." [] subset: http://purl.obolibrary.org/obo/valid_for_go_annotation_extension subset: http://purl.obolibrary.org/obo/valid_for_go_ontology subset: http://purl.obolibrary.org/obo/valid_for_gocam subset: ro-eco property_value: seeAlso "https://wiki.geneontology.org/Has_input" xsd:anyURI domain: BFO:0000015 holds_over_chain: RO:0002224 RO:0002233 is_a: has_participant ! has participant inverse_of: RO:0002352 ! input of [Typedef] id: RO:0002234 name: has output def: "p has output c iff c is a participant in p, c is present at the end of p, and c is not present in the same state at the beginning of p." [] subset: http://purl.obolibrary.org/obo/valid_for_go_annotation_extension subset: http://purl.obolibrary.org/obo/valid_for_go_ontology subset: http://purl.obolibrary.org/obo/valid_for_gocam subset: ro-eco property_value: seeAlso "https://wiki.geneontology.org/Has_output" xsd:anyURI holds_over_chain: RO:0002230 RO:0002234 is_a: has_participant ! has participant inverse_of: RO:0002353 ! output of [Typedef] id: RO:0002252 name: connecting branch of def: "b connecting-branch-of s iff b is connected to s, and there exists some tree-like structure t such that the mereological sum of b plus s is either the same as t or a branching-part-of t." [] property_value: seeAlso https://github.com/obophenotype/uberon/issues/2212 is_a: RO:0002170 ! connected to is_a: RO:0002375 ! in branching relationship with inverse_of: RO:0002253 ! has connecting branch [Typedef] id: RO:0002253 name: has connecting branch def: "inverse of connecting branch of" [] subset: RO:0002259 is_a: RO:0002375 ! in branching relationship with [Typedef] id: RO:0002254 name: has developmental contribution from def: "x has developmental contribution from y iff x has some part z such that z develops from y" [] domain: UBERON:0001062 ! anatomical entity range: UBERON:0001062 ! anatomical entity holds_over_chain: BFO:0000051 RO:0002254 is_a: RO:0002258 ! developmentally preceded by inverse_of: RO:0002255 ! developmentally contributes to [Typedef] id: RO:0002255 name: developmentally contributes to def: "inverse of has developmental contribution from" [] subset: RO:0002259 holds_over_chain: RO:0002203 BFO:0000050 is_a: RO:0002286 ! developmentally succeeded by is_a: RO:0002385 ! has potential to developmentally contribute to [Typedef] id: RO:0002256 name: developmentally induced by def: "t1 induced_by t2 if there is a process of developmental induction (GO:0031128) with t1 and t2 as interacting participants. t2 causes t1 to change its fate from a precursor material anatomical entity type T to T', where T' develops_from T" [] domain: UBERON:0000465 ! material anatomical entity range: UBERON:0000465 ! material anatomical entity is_a: RO:0002258 ! developmentally preceded by inverse_of: RO:0002257 ! developmentally induces [Typedef] id: RO:0002257 name: developmentally induces def: "Inverse of developmentally induced by" [] is_a: RO:0002286 ! developmentally succeeded by is_a: RO:0002386 ! has potential to developmentally induce [Typedef] id: RO:0002258 name: developmentally preceded by def: "Candidate definition: x developmentally related to y if and only if there exists some developmental process (GO:0032502) p such that x and y both participates in p, and x is the output of p and y is the input of p" [] comment: This relation groups together various other developmental relations. It is fairly generic, encompassing induction, developmental contribution and direct and transitive develops from property_value: IAO:0000116 "false" xsd:boolean domain: BFO:0000002 range: BFO:0000002 is_a: RO:0002324 ! developmentally related to inverse_of: RO:0002286 ! developmentally succeeded by [Typedef] id: RO:0002263 name: acts upstream of def: "c acts upstream of p if and only if c enables some f that is involved in p' and p' occurs chronologically before p, is not part of p, and affects the execution of p. c is a material entity and f, p, p' are processes." [] subset: http://purl.obolibrary.org/obo/valid_for_go_gp2term property_value: seeAlso http://wiki.geneontology.org/index.php/Acts_upstream_of is_a: RO:0002264 ! acts upstream of or within [Typedef] id: RO:0002264 name: acts upstream of or within def: "c acts upstream of or within p if c is enables f, and f is causally upstream of or within p. c is a material entity and p is an process." [] subset: http://purl.obolibrary.org/obo/valid_for_go_gp2term synonym: "affects" RELATED [] property_value: seeAlso "https://wiki.geneontology.org/Acts_upstream_of_or_within" xsd:anyURI is_a: RO:0002500 ! causal agent in process [Typedef] id: RO:0002285 name: developmentally replaces def: "x developmentally replaces y if and only if there is some developmental process that causes x to move or to cease to exist, and for the site that was occupied by x to become occupied by y, where y either comes into existence in this site or moves to this site from somewhere else" [] property_value: IAO:0000116 "This relation is intended for cases such as when we have a bone element replacing its cartilage element precursor. Currently most AOs represent this using 'develops from'. We need to decide whether 'develops from' will be generic and encompass replacement, or whether we need a new name for a generic relation that encompasses replacement and development-via-cell-lineage" xsd:string is_a: RO:0002258 ! developmentally preceded by [Typedef] id: RO:0002286 name: developmentally succeeded by def: "Inverse of developmentally preceded by" [] is_a: RO:0002384 ! has developmental potential involving [Typedef] id: RO:0002287 name: part of developmental precursor of holds_over_chain: BFO:0000050 RO:0002210 is_a: RO:0002286 ! developmentally succeeded by [Typedef] id: RO:0002292 name: expresses def: "y expresses x if and only if there is a gene expression process (GO:0010467) that occurs in y, and one of the following holds: (i) x is a gene, and x is transcribed into a transcript as part of the gene expression process (ii) x is a transcript, and x was transcribed from a gene as part of the gene expression process (iii) x is a mature gene product (protein or RNA), and x was translated or otherwise processed from a transcript that was transcribed as part of the gene expression process." [] is_a: RO:0002330 ! genomically related to [Typedef] id: RO:0002295 name: results in developmental progression of def: "p results in the developmental progression of s iff p is a developmental process and s is an anatomical entity and p causes s to undergo a change in state at some point along its natural developmental cycle (this cycle starts with its formation, through the mature structure, and ends with its loss)." [] property_value: IAO:0000116 "This property and its subproperties are being used primarily for the definition of GO developmental processes. The property hierarchy mirrors the core GO hierarchy. In future we may be able to make do with a more minimal set of properties, but due to the way GO is currently structured we require highly specific relations to avoid incorrect entailments. To avoid this, the corresponding genus terms in GO should be declared mutually disjoint." xsd:string property_value: seeAlso Ontology:extensions domain: GO:0008150 ! biological_process range: UBERON:0001062 ! anatomical entity is_a: RO:0002324 ! developmentally related to [Typedef] id: RO:0002296 name: results in development of def: "p 'results in development of' c if and only if p is a developmental process and p results in the state of c changing from its initial state as a primordium or anlage through its mature state and to its final state." [] subset: http://purl.obolibrary.org/obo/valid_for_go_annotation_extension subset: http://purl.obolibrary.org/obo/valid_for_go_ontology subset: http://purl.obolibrary.org/obo/valid_for_gocam is_a: RO:0002295 ! results in developmental progression of is_a: RO:0040036 ! results in changes to anatomical or cellular structure [Typedef] id: RO:0002297 name: results in formation of anatomical entity subset: http://purl.obolibrary.org/obo/valid_for_go_annotation_extension subset: http://purl.obolibrary.org/obo/valid_for_go_ontology subset: http://purl.obolibrary.org/obo/valid_for_gocam is_a: RO:0002234 ! has output is_a: RO:0002295 ! results in developmental progression of inverse_of: RO:0002354 ! formed as result of [Typedef] id: RO:0002298 name: results in morphogenesis of def: "The relationship that links an entity with the process that results in the formation and shaping of that entity over time from an immature to a mature state." [] subset: http://purl.obolibrary.org/obo/valid_for_go_annotation_extension subset: http://purl.obolibrary.org/obo/valid_for_go_ontology subset: http://purl.obolibrary.org/obo/valid_for_gocam is_a: RO:0002295 ! results in developmental progression of is_a: RO:0040036 ! results in changes to anatomical or cellular structure [Typedef] id: RO:0002299 name: results in maturation of def: "The relationship that links an entity with a process that results in the progression of the entity over time that is independent of changes in it's shape and results in an end point state of that entity." [] subset: http://purl.obolibrary.org/obo/valid_for_go_annotation_extension subset: http://purl.obolibrary.org/obo/valid_for_go_ontology subset: http://purl.obolibrary.org/obo/valid_for_gocam is_a: RO:0002295 ! results in developmental progression of is_a: RO:0040036 ! results in changes to anatomical or cellular structure [Typedef] id: RO:0002304 name: causally upstream of, positive effect def: "p is causally upstream of, positive effect q iff p is casually upstream of q, and the execution of p is required for the execution of q." [] comment: holds between x and y if and only if x is causally upstream of y and the progression of x increases the frequency, rate or extent of y subset: http://purl.obolibrary.org/obo/valid_for_go_annotation_extension subset: http://purl.obolibrary.org/obo/valid_for_gocam property_value: seeAlso https://wiki.geneontology.org/Causally_upstream_of,_positive_effect property_value: terms:creator https://orcid.org/0000-0002-6601-2165 is_a: RO:0002411 ! causally upstream of is_a: RO:0004047 ! causally upstream of or within, positive effect [Typedef] id: RO:0002305 name: causally upstream of, negative effect def: "p is causally upstream of, negative effect q iff p is casually upstream of q, and the execution of p decreases the execution of q." [] subset: http://purl.obolibrary.org/obo/valid_for_go_annotation_extension subset: http://purl.obolibrary.org/obo/valid_for_gocam property_value: RO:0004050 RO:0002411 property_value: seeAlso https://wiki.geneontology.org/Causally_upstream_of,_negative_effect property_value: terms:creator https://orcid.org/0000-0002-6601-2165 is_a: RO:0002411 ! causally upstream of is_a: RO:0004046 ! causally upstream of or within, negative effect [Typedef] id: RO:0002314 name: characteristic of part of def: "q characteristic of part of w if and only if there exists some p such that q inheres in p and p part of w." [] property_value: IAO:0000116 "Because part_of is transitive, inheres in is a sub-relation of characteristic of part of" xsd:string property_value: seeAlso http://purl.obolibrary.org/obo/ro/docs/reflexivity/ is_a: RO:0002502 ! depends on transitive_over: BFO:0000050 ! part of [Typedef] id: RO:0002315 name: results in acquisition of features of def: "The relationship that links a specified entity with the process that results in an unspecified entity acquiring the features and characteristics of the specified entity" [] subset: http://purl.obolibrary.org/obo/valid_for_go_annotation_extension subset: http://purl.obolibrary.org/obo/valid_for_go_ontology subset: http://purl.obolibrary.org/obo/valid_for_gocam range: UBERON:0000061 ! anatomical structure is_a: RO:0002295 ! results in developmental progression of is_a: RO:0040036 ! results in changes to anatomical or cellular structure [Typedef] id: RO:0002320 name: evolutionarily related to def: "A relationship that holds via some environmental process" [] [Typedef] id: RO:0002323 name: mereotopologically related to def: "A mereological relationship or a topological relationship" [] [Typedef] id: RO:0002324 name: developmentally related to def: "A relationship that holds between entities participating in some developmental process (GO:0032502)" [] [Typedef] id: RO:0002328 name: functionally related to def: "A grouping relationship for any relationship directly involving a function, or that holds because of a function of one of the related entities." [] [Typedef] id: RO:0002329 name: part of structure that is capable of def: "this relation holds between c and p when c is part of some c', and c' is capable of p." [] is_a: RO:0002328 ! functionally related to [Typedef] id: RO:0002330 name: genomically related to def: "holds between two entities when some genome-level process such as gene expression is involved. This includes transcriptional, spliceosomal events. These relations can be used between either macromolecule entities (such as regions of nucleic acid) or between their abstract informational counterparts." [] domain: BFO:0000002 range: BFO:0000002 [Typedef] id: RO:0002332 name: regulates levels of def: "p regulates levels of c if p regulates some amount (PATO:0000070) of c" [] domain: BFO:0000015 range: BFO:0000040 is_a: RO:0002328 ! functionally related to [Typedef] id: RO:0002334 name: regulated by def: "inverse of regulates" [] subset: RO:0002259 domain: BFO:0000015 range: BFO:0000015 is_transitive: true is_a: RO:0002427 ! causally downstream of or within [Typedef] id: RO:0002335 name: negatively regulated by def: "inverse of negatively regulates" [] subset: RO:0002259 is_a: RO:0002334 ! regulated by [Typedef] id: RO:0002336 name: positively regulated by def: "inverse of positively regulates" [] subset: RO:0002259 is_a: RO:0002334 ! regulated by [Typedef] id: RO:0002337 name: related via localization to def: "A relationship that holds via some process of localization" [] domain: BFO:0000015 range: BFO:0000002 [Typedef] id: RO:0002338 name: has target start location def: "This relationship holds between p and l when p is a transport or localization process in which the outcome is to move some cargo c from some initial location l to some destination." [] subset: http://purl.obolibrary.org/obo/valid_for_go_annotation_extension subset: http://purl.obolibrary.org/obo/valid_for_go_ontology subset: http://purl.obolibrary.org/obo/valid_for_gocam is_a: RO:0002344 ! results in transport to from or in transitive_over: BFO:0000050 ! part of [Typedef] id: RO:0002339 name: has target end location def: "This relationship holds between p and l when p is a transport or localization process in which the outcome is to move some cargo c from a an initial location to some destination l." [] subset: http://purl.obolibrary.org/obo/valid_for_go_annotation_extension subset: http://purl.obolibrary.org/obo/valid_for_go_ontology subset: http://purl.obolibrary.org/obo/valid_for_gocam is_a: RO:0002344 ! results in transport to from or in transitive_over: BFO:0000050 ! part of [Typedef] id: RO:0002341 name: results in transport along def: "Holds between p and l when p is a transportation or localization process and the outcome of this process is to move c from one location to another, and the route taken by c follows a path that is aligned_with l " [] is_a: RO:0002337 ! related via localization to [Typedef] id: RO:0002342 name: results in transport across def: "Holds between p and m when p is a transportation or localization process and the outcome of this process is to move c from one location to another, and the route taken by c follows a path that crosses m." [] subset: http://purl.obolibrary.org/obo/valid_for_go_ontology is_a: RO:0002021 ! occurs across is_a: RO:0002344 ! results in transport to from or in [Typedef] id: RO:0002343 name: results in growth of is_a: RO:0002295 ! results in developmental progression of is_a: RO:0040036 ! results in changes to anatomical or cellular structure [Typedef] id: RO:0002344 name: results in transport to from or in is_a: RO:0002337 ! related via localization to [Typedef] id: RO:0002350 name: member of def: "is member of is a mereological relation between a item and a collection." [] is_a: BFO:0000050 ! part of inverse_of: RO:0002351 ! has member [Typedef] id: RO:0002351 name: has member def: "has member is a mereological relation between a collection and an item." [] is_a: BFO:0000051 ! has part [Typedef] id: RO:0002352 name: input of def: "inverse of has input" [] subset: ro-eco subset: RO:0002259 is_a: RO:0000056 ! participates in is_a: RO:0002328 ! functionally related to [Typedef] id: RO:0002353 name: output of def: "inverse of has output" [] subset: ro-eco subset: RO:0002259 is_a: RO:0000056 ! participates in is_a: RO:0002328 ! functionally related to [Typedef] id: RO:0002354 name: formed as result of is_a: RO:0002353 ! output of [Typedef] id: RO:0002360 name: has dendrite location is_a: RO:0002131 ! overlaps [Typedef] id: RO:0002371 name: attached to def: "a is attached to b if and only if a and b are discrete objects or object parts, and there are physical connections between a and b such that a force pulling a will move b, or a force pulling b will move a" [] subset: ro-eco is_symmetric: true is_a: RO:0002170 ! connected to is_a: RO:0002177 ! attached to part of [Typedef] id: RO:0002372 name: has muscle origin def: "m has_muscle_origin s iff m is attached_to s, and it is the case that when m contracts, s does not move. The site of the origin tends to be more proximal and have greater mass than what the other end attaches to." [] property_value: seeAlso http://dbpedia.org/property/origin domain: UBERON:0000061 {comment="We need to import uberon muscle to create a stricter domain constraint"} ! anatomical structure is_a: RO:0002371 ! attached to is_a: RO:0002567 ! biomechanically related to [Typedef] id: RO:0002373 name: has muscle insertion def: "m has_muscle_insertion s iff m is attaches_to s, and it is the case that when m contracts, s moves. Insertions are usually connections of muscle via tendon to bone." [] property_value: seeAlso http://dbpedia.org/property/insertion domain: UBERON:0000061 {IAO:0000116="We need to import uberon muscle into RO to use as a stricter domain constraint"} ! anatomical structure is_a: RO:0002371 ! attached to is_a: RO:0002567 ! biomechanically related to [Typedef] id: RO:0002375 name: in branching relationship with def: "A relationship that holds between two material entities in a system of connected structures, where the branching relationship holds based on properties of the connecting network." [] property_value: seeAlso http://purl.obolibrary.org/obo/ro/docs/branching_part_of.png property_value: seeAlso "https://github.com/obophenotype/uberon/issues/170" xsd:anyURI domain: BFO:0000040 range: BFO:0000040 is_a: RO:0002323 ! mereotopologically related to [Typedef] id: RO:0002376 name: tributary of def: "x tributary_of y if and only if x a channel for the flow of a substance into y, where y is larger than x. If x and y are hydrographic features, then y is the main stem of a river, or a lake or bay, but not the sea or ocean. If x and y are anatomical, then y is a vein." [] subset: ro-eco property_value: seeAlso http://dbpedia.org/ontology/drainsTo property_value: seeAlso "http://en.wikipedia.org/wiki/Tributary" xsd:anyURI is_a: RO:0002170 ! connected to is_a: RO:0002375 ! in branching relationship with [Typedef] id: RO:0002379 name: spatially coextensive with def: "x spatially_coextensive_with y if and inly if x and y have the same location" [] is_a: RO:0002131 ! overlaps [Typedef] id: RO:0002380 name: branching part of def: "x is a branching part of y if and only if x is part of y and x is connected directly or indirectly to the main stem of y" [] subset: ro-eco property_value: seeAlso "FMA:85994" xsd:string property_value: seeAlso https://github.com/obophenotype/uberon/issues/2212 is_a: BFO:0000050 ! part of is_a: RO:0002375 ! in branching relationship with inverse_of: RO:0002569 ! has branching part [Typedef] id: RO:0002384 name: has developmental potential involving def: "x has developmental potential involving y iff x is capable of a developmental process with output y. y may be the successor of x, or may be a different structure in the vicinity (as for example in the case of developmental induction)." [] domain: UBERON:0001062 ! anatomical entity range: UBERON:0001062 ! anatomical entity is_a: RO:0002324 ! developmentally related to [Typedef] id: RO:0002385 name: has potential to developmentally contribute to def: "x has potential to developmentrally contribute to y iff x developmentally contributes to y or x is capable of developmentally contributing to y" [] is_a: RO:0002384 ! has developmental potential involving [Typedef] id: RO:0002386 name: has potential to developmentally induce def: "x has potential to developmentally induce y iff x developmentally induces y or x is capable of developmentally inducing y" [] is_a: RO:0002384 ! has developmental potential involving [Typedef] id: RO:0002387 name: has potential to develop into def: "x has the potential to develop into y iff x develops into y or if x is capable of developing into y" [] comment: This relation has a stronger meaning than merely indicating that X may develop into Y, in that the capability of developing into Y is always present, even if X does not always actually develop into Y. In particular, this means that if Y is restricted to a given taxon T, X is necessarily likewise restricted. property_value: seeAlso https://github.com/oborel/obo-relations/issues/810 is_a: RO:0002384 ! has developmental potential involving [Typedef] id: RO:0002388 name: has potential to directly develop into def: "x has potential to directly develop into y iff x directly develops into y or x is capable of directly developing into y" [] is_a: RO:0002387 ! has potential to develop into [Typedef] id: RO:0002404 name: causally downstream of def: "inverse of upstream of" [] is_a: BFO:0000062 ! preceded by is_a: RO:0002427 ! causally downstream of or within inverse_of: RO:0002411 ! causally upstream of [Typedef] id: RO:0002405 name: immediately causally downstream of is_a: RO:0002087 ! immediately preceded by is_a: RO:0002404 ! causally downstream of inverse_of: RO:0002412 ! immediately causally upstream of [Typedef] id: RO:0002410 name: causally related to def: "relation that links two events, processes, states, or objects such that one event, process, state, or object (a cause) contributes to the production of another event, process, state, or object (an effect) where the cause is partly or wholly responsible for the effect, and the effect is partly or wholly dependent on the cause." [https://en.wikipedia.org/wiki/Causality] property_value: IAO:0000116 "This branch of the ontology deals with causal relations between entities. It is divided into two branches: causal relations between occurrents/processes, and causal relations between material entities. We take an 'activity flow-centric approach', with the former as primary, and define causal relations between material entities in terms of causal relations between occurrents.\n\nTo define causal relations in an activity-flow type network, we make use of 3 primitives:\n\n * Temporal: how do the intervals of the two occurrents relate? \n * Is the causal relation regulatory?\n * Is the influence positive or negative?\n\nThe first of these can be formalized in terms of the Allen Interval Algebra. Informally, the 3 bins we care about are 'direct', 'indirect' or overlapping. Note that all causal relations should be classified under a RO temporal relation (see the branch under 'temporally related to'). Note that all causal relations are temporal, but not all temporal relations are causal. Two occurrents can be related in time without being causally connected. We take causal influence to be primitive, elucidated as being such that has the upstream changed, some qualities of the donwstream would necessarily be modified.\n\nFor the second, we consider a relationship to be regulatory if the system in which the activities occur is capable of altering the relationship to achieve some objective. This could include changing the rate of production of a molecule.\n\nFor the third, we consider the effect of the upstream process on the output(s) of the downstream process. If the level of output is increased, or the rate of production of the output is increased, then the direction is increased. Direction can be positive, negative or neutral or capable of either direction. Two positives in succession yield a positive, two negatives in succession yield a positive, otherwise the default assumption is that the net effect is canceled and the influence is neutral.\n\nEach of these 3 primitives can be composed to yield a cross-product of different relation types." xsd:string [Typedef] id: RO:0002411 name: causally upstream of def: "p is causally upstream of q iff p is causally related to q, the end of p precedes the end of q, and p is not an occurrent part of q." [] subset: http://purl.obolibrary.org/obo/valid_for_go_annotation_extension subset: http://purl.obolibrary.org/obo/valid_for_gocam is_transitive: true is_a: BFO:0000063 ! precedes is_a: RO:0002418 ! causally upstream of or within [Typedef] id: RO:0002412 name: immediately causally upstream of def: "p is immediately causally upstream of q iff p is causally upstream of q, and the end of p is coincident with the beginning of q." [] is_a: RO:0002090 ! immediately precedes is_a: RO:0002411 ! causally upstream of [Typedef] id: RO:0002413 name: provides input for def: "p provides input for q iff p is immediately causally upstream of q, and there exists some c such that p has_output c and q has_input c." [] property_value: seeAlso "https://wiki.geneontology.org/Provides_input_for" xsd:anyURI holds_over_chain: RO:0002234 RO:0002233 is_a: RO:0002412 ! immediately causally upstream of is_a: RO:0002414 ! transitively provides input for [Typedef] id: RO:0002414 name: transitively provides input for def: "transitive form of directly_provides_input_for" [] domain: BFO:0000015 range: BFO:0000015 is_transitive: true is_a: RO:0004047 ! causally upstream of or within, positive effect [Typedef] id: RO:0002418 name: causally upstream of or within def: "p is 'causally upstream or within' q iff p is causally related to q, and the end of p precedes, or is coincident with, the end of q." [] synonym: "affects" RELATED [] property_value: IAO:0000116 "We would like to make this disjoint with 'preceded by', but this is prohibited in OWL2" xsd:string is_transitive: true is_a: RO:0002501 ! causal relation between processes inverse_of: RO:0002427 ! causally downstream of or within transitive_over: BFO:0000050 ! part of [Typedef] id: RO:0002427 name: causally downstream of or within def: "inverse of causally upstream of or within" [] subset: RO:0002259 is_transitive: true is_a: RO:0002501 ! causal relation between processes [Typedef] id: RO:0002428 name: involved in regulation of def: "c involved in regulation of p if c is involved in some p' and p' regulates some p" [] is_a: RO:0002263 ! acts upstream of is_a: RO:0002431 ! involved in or involved in regulation of [Typedef] id: RO:0002431 name: involved in or involved in regulation of def: "c involved in or regulates p if and only if either (i) c is involved in p or (ii) c is involved in regulation of p" [] property_value: IAO:0000116 "OWL does not allow defining object properties via a Union" xsd:string is_a: RO:0002264 ! acts upstream of or within is_a: RO:0002328 ! functionally related to is_a: RO:0002500 ! causal agent in process [Typedef] id: RO:0002433 name: contributes to morphology of def: "p contributes to morphology of w if and only if a change in the morphology of p entails a change in the morphology of w. Examples: every skull contributes to morphology of the head which it is a part of. Counter-example: nuclei do not generally contribute to the morphology of the cell they are part of, as they are buffered by cytoplasm." [] is_a: RO:0002131 ! overlaps [Typedef] id: RO:0002464 name: helper property (not for use in curation) [Typedef] id: RO:0002473 name: composed primarily of def: "x composed_primarily_of y if and only if more than half of the mass of x is made from y or units of the same type as y." [] subset: ro-eco domain: BFO:0000040 range: BFO:0000040 is_a: BFO:0000051 ! has part [Typedef] id: RO:0002479 name: has part that occurs in def: "p has part that occurs in c if and only if there exists some p1, such that p has_part p1, and p1 occurs in c." [] subset: ro-eco domain: BFO:0000003 range: BFO:0000004 [Typedef] id: RO:0002481 name: is kinase activity is_a: RO:0002564 ! molecular interaction relation helper property [Typedef] id: RO:0002485 name: receives input from property_value: IAO:0000116 "See notes for inverse relation" xsd:string is_a: RO:0002170 ! connected to inverse_of: RO:0002486 ! sends output to [Typedef] id: RO:0002486 name: sends output to property_value: IAO:0000116 "This is an exploratory relation. The label is taken from the FMA. It needs aligned with the neuron-specific relations such as has postsynaptic terminal in." xsd:string is_a: RO:0002170 ! connected to [Typedef] id: RO:0002487 name: relation between physical entity and a process or stage domain: BFO:0000004 range: BFO:0000003 [Typedef] id: RO:0002488 name: existence starts during def: "x existence starts during y if and only if the time point at which x starts is after or equivalent to the time point at which y starts and before or equivalent to the time point at which y ends. Formally: x existence starts during y iff α(x) >= α(y) & α(x) <= ω(y)." [] is_a: RO:0002490 ! existence overlaps is_a: RO:0002496 ! existence starts during or after transitive_over: BFO:0000050 ! part of [Typedef] id: RO:0002489 name: existence starts with def: "x starts ends with y if and only if the time point at which x starts is equivalent to the time point at which y starts. Formally: x existence starts with y iff α(x) = α(y)." [] is_a: RO:0002488 ! existence starts during [Typedef] id: RO:0002490 name: existence overlaps def: "x existence overlaps y if and only if either (a) the start of x is part of y or (b) the end of x is part of y. Formally: x existence starts and ends during y iff (α(x) >= α(y) & α(x) <= ω(y)) OR (ω(x) <= ω(y) & ω(x) >= α(y))" [] comment: The relations here were created based on work originally by Fabian Neuhaus and David Osumi-Sutherland. The work has not yet been vetted and errors in definitions may have occurred during transcription. is_a: RO:0002487 ! relation between physical entity and a process or stage [Typedef] id: RO:0002491 name: existence starts and ends during def: "x exists during y if and only if: 1) the time point at which x begins to exist is after or equal to the time point at which y begins and 2) the time point at which x ceases to exist is before or equal to the point at which y ends. Formally: x existence starts and ends during y iff α(x) >= α(y) & α(x) <= ω(y) & ω(x) <= ω(y) & ω(x) >= α(y)" [] comment: The relations here were created based on work originally by Fabian Neuhaus and David Osumi-Sutherland. The work has not yet been vetted and errors in definitions may have occurred during transcription. synonym: "exists during" EXACT [] is_a: RO:0002488 ! existence starts during is_a: RO:0002492 ! existence ends during [Typedef] id: RO:0002492 name: existence ends during def: "x existence ends during y if and only if the time point at which x ends is before or equivalent to the time point at which y ends and after or equivalent to the point at which y starts. Formally: x existence ends during y iff ω(x) <= ω(y) and ω(x) >= α(y)." [] comment: The relations here were created based on work originally by Fabian Neuhaus and David Osumi-Sutherland. The work has not yet been vetted and errors in definitions may have occurred during transcription. is_a: RO:0002490 ! existence overlaps is_a: RO:0002497 ! existence ends during or before transitive_over: BFO:0000050 ! part of [Typedef] id: RO:0002493 name: existence ends with def: "x existence ends with y if and only if the time point at which x ends is equivalent to the time point at which y ends. Formally: x existence ends with y iff ω(x) = ω(y)." [] comment: The relations here were created based on work originally by Fabian Neuhaus and David Osumi-Sutherland. The work has not yet been vetted and errors in definitions may have occurred during transcription. is_a: RO:0002492 ! existence ends during [Typedef] id: RO:0002494 name: transformation of def: "x transformation of y if x is the immediate transformation of y, or is linked to y through a chain of transformation relationships" [] is_transitive: true is_a: RO:0002202 ! develops from [Typedef] id: RO:0002495 name: immediate transformation of def: "x immediate transformation of y iff x immediately succeeds y temporally at a time boundary t, and all of the matter present in x at t is present in y at t, and all the matter in y at t is present in x at t" [] is_a: RO:0002207 ! directly develops from is_a: RO:0002494 ! transformation of [Typedef] id: RO:0002496 name: existence starts during or after def: "x existence starts during or after y if and only if the time point at which x starts is after or equivalent to the time point at which y starts. Formally: x existence starts during or after y iff α (x) >= α (y)." [] comment: The relations here were created based on work originally by Fabian Neuhaus and David Osumi-Sutherland. The work has not yet been vetted and errors in definitions may have occurred during transcription. holds_over_chain: BFO:0000050 RO:0002496 holds_over_chain: RO:0002258 RO:0002496 is_a: RO:0002487 ! relation between physical entity and a process or stage transitive_over: BFO:0000050 ! part of transitive_over: BFO:0000062 ! preceded by transitive_over: RO:0002082 ! simultaneous with [Typedef] id: RO:0002497 name: existence ends during or before def: "x existence ends during or before y if and only if the time point at which x ends is before or equivalent to the time point at which y ends." [] comment: The relations here were created based on work originally by Fabian Neuhaus and David Osumi-Sutherland. The work has not yet been vetted and errors in definitions may have occurred during transcription. holds_over_chain: BFO:0000050 RO:0002497 holds_over_chain: RO:0002286 RO:0002497 is_a: RO:0002487 ! relation between physical entity and a process or stage transitive_over: BFO:0000050 ! part of transitive_over: BFO:0000063 ! precedes transitive_over: RO:0002082 ! simultaneous with [Typedef] id: RO:0002500 name: causal agent in process def: "A relationship between a material entity and a process where the material entity has some causal role that influences the process" [] is_a: RO:0002595 ! causal relation between material entity and a process inverse_of: RO:0002608 ! process has causal agent [Typedef] id: RO:0002501 name: causal relation between processes def: "p is causally related to q if and only if p or any part of p and q or any part of q are linked by a chain of events where each event pair is one where the execution of p influences the execution of q. p may be upstream, downstream, part of, or a container of q." [] domain: BFO:0000003 range: BFO:0000003 is_a: RO:0002410 ! causally related to [Typedef] id: RO:0002502 name: depends on property_value: seeAlso BFO:0000169 [Typedef] id: RO:0002551 name: has skeleton def: "A relation between a segment or subdivision of an organism and the maximal subdivision of material entities that provides structural support for that segment or subdivision." [] domain: UBERON:0000061 ! anatomical structure range: UBERON:0000465 {IAO:0000116="This should be to a more restricted class, but not the Uberon class may be too restricted since it is a composition-based definition of skeleton rather than functional."} ! material anatomical entity is_a: BFO:0000051 ! has part inverse_of: RO:0002576 ! skeleton of is_asymmetric: true [Typedef] id: RO:0002563 name: interaction relation helper property property_value: seeAlso http://ontologydesignpatterns.org/wiki/Submissions:N-Ary_Relation_Pattern_%28OWL_2%29 property_value: seeAlso "http://purl.obolibrary.org/obo/ro/docs/interaction-relations/" xsd:anyURI is_a: RO:0002464 ! helper property (not for use in curation) [Typedef] id: RO:0002564 name: molecular interaction relation helper property is_a: RO:0002563 ! interaction relation helper property [Typedef] id: RO:0002565 name: results in movement of def: "Holds between p and c when p is locomotion process and the outcome of this process is the change of location of c" [] subset: http://purl.obolibrary.org/obo/valid_for_go_annotation_extension subset: http://purl.obolibrary.org/obo/valid_for_go_ontology subset: http://purl.obolibrary.org/obo/valid_for_gocam is_a: RO:0040036 ! results in changes to anatomical or cellular structure [Typedef] id: RO:0002567 name: biomechanically related to def: "A relation that holds between elements of a musculoskeletal system or its analogs." [] domain: UBERON:0000061 ! anatomical structure range: UBERON:0000061 ! anatomical structure is_a: RO:0002328 ! functionally related to [Typedef] id: RO:0002568 name: has muscle antagonist def: "m1 has_muscle_antagonist m2 iff m1 has_muscle_insertion s, m2 has_muscle_insection s, m1 acts in opposition to m2, and m2 is responsible for returning the structure to its initial position." [] is_a: RO:0002567 ! biomechanically related to [Typedef] id: RO:0002569 name: has branching part def: "inverse of branching part of" [] subset: ro-eco subset: RO:0002259 is_transitive: true is_a: BFO:0000051 ! has part is_a: RO:0002375 ! in branching relationship with [Typedef] id: RO:0002570 name: conduit for def: "x is a conduit for y iff y overlaps through the lumen_of of x, and y has parts on either side of the lumen of x." [] subset: ro-eco domain: BFO:0000040 range: BFO:0000040 is_a: RO:0002131 ! overlaps [Typedef] id: RO:0002571 name: lumen of def: "x lumen_of y iff x is the space or substance that is part of y and does not cross any of the inner membranes or boundaries of y that is maximal with respect to the volume of the convex hull." [] subset: ro-eco range: BFO:0000040 is_a: BFO:0000050 ! part of [Typedef] id: RO:0002572 name: luminal space of def: "s is luminal space of x iff s is lumen_of x and s is an immaterial entity" [] subset: ro-eco domain: BFO:0000141 is_a: RO:0002571 ! lumen of [Typedef] id: RO:0002576 name: skeleton of def: "inverse of has skeleton" [] subset: RO:0002259 domain: UBERON:0000061 ! anatomical structure range: UBERON:0000061 ! anatomical structure is_a: BFO:0000050 ! part of [Typedef] id: RO:0002584 name: has part structure that is capable of def: "s 'has part structure that is capable of' p if and only if there exists some part x such that s 'has part' x and x 'capable of' p" [] holds_over_chain: BFO:0000051 RO:0002215 is_a: RO:0002328 ! functionally related to is_a: RO:0002595 ! causal relation between material entity and a process [Typedef] id: RO:0002586 name: results in breakdown of def: "p results in breakdown of c if and only if the execution of p leads to c no longer being present at the end of p" [] is_a: RO:0002233 ! has input [Typedef] id: RO:0002588 name: results in assembly of subset: http://purl.obolibrary.org/obo/valid_for_go_annotation_extension subset: http://purl.obolibrary.org/obo/valid_for_go_ontology subset: http://purl.obolibrary.org/obo/valid_for_gocam is_a: RO:0002297 ! results in formation of anatomical entity is_a: RO:0002592 ! results in organization of [Typedef] id: RO:0002590 name: results in disassembly of is_a: RO:0002586 ! results in breakdown of is_a: RO:0002592 ! results in organization of [Typedef] id: RO:0002592 name: results in organization of def: "p results in organization of c iff p results in the assembly, arrangement of constituent parts, or disassembly of c" [] is_a: RO:0040036 ! results in changes to anatomical or cellular structure [Typedef] id: RO:0002595 name: causal relation between material entity and a process def: "A relationship that holds between a material entity and a process in which causality is involved, with either the material entity or some part of the material entity exerting some influence over the process, or the process influencing some aspect of the material entity." [] property_value: IAO:0000116 "Do not use this relation directly. It is intended as a grouping for a diverse set of relations, all involving cause and effect." xsd:string domain: BFO:0000040 range: BFO:0000015 is_a: RO:0002410 ! causally related to [Typedef] id: RO:0002596 name: capable of regulating def: "Holds between c and p if and only if c is capable of some activity a, and a regulates p." [] holds_over_chain: RO:0002215 RO:0002211 is_a: RO:0002500 ! causal agent in process [Typedef] id: RO:0002597 name: capable of negatively regulating def: "Holds between c and p if and only if c is capable of some activity a, and a negatively regulates p." [] holds_over_chain: RO:0002215 RO:0002212 is_a: RO:0002596 ! capable of regulating [Typedef] id: RO:0002598 name: capable of positively regulating def: "Holds between c and p if and only if c is capable of some activity a, and a positively regulates p." [] holds_over_chain: RO:0002215 RO:0002213 is_a: RO:0002596 ! capable of regulating [Typedef] id: RO:0002608 name: process has causal agent def: "Inverse of 'causal agent in process'" [] is_a: RO:0002410 ! causally related to [Typedef] id: RO:0003000 name: produces def: "a produces b if some process that occurs_in a has_output b, where a and b are material entities. Examples: hybridoma cell line produces monoclonal antibody reagent; chondroblast produces avascular GAG-rich matrix." [] comment: Note that this definition doesn't quite distinguish the output of a transformation process from a production process, which is related to the identity/granularity issue. subset: ro-eco domain: BFO:0000040 range: BFO:0000040 inverse_of: RO:0003001 ! produced by [Typedef] id: RO:0003001 name: produced by def: "a produced_by b iff some process that occurs_in b has_output a." [] subset: ro-eco domain: BFO:0000040 range: BFO:0000040 [Typedef] id: RO:0004007 name: has primary input or output def: "p 'has primary input ot output' c iff either (a) p 'has primary input' c or (b) p 'has primary output' c." [] subset: http://purl.obolibrary.org/obo/valid_for_go_ontology is_a: has_participant ! has participant creation_date: 2018-12-13T11:26:17Z [Typedef] id: RO:0004008 name: has primary output def: "p has primary output c if (a) p has output c and (b) the goal of process is to modify, produce, or transform c." [GOC:dph, GOC:kva, GOC:pt, https://orcid.org/0000-0002-6601-2165] {comment="PMID:27812932"} subset: http://purl.obolibrary.org/obo/valid_for_go_ontology is_a: RO:0002234 ! has output is_a: RO:0004007 ! has primary input or output creation_date: 2018-12-13T11:26:32Z [Typedef] id: RO:0004009 name: has primary input def: "p has primary input c if (a) p has input c and (b) the goal of process is to modify, consume, or transform c." [GOC:dph, GOC:kva, GOC:pt, https://orcid.org/0000-0002-6601-2165] {comment="PMID:27812932"} subset: http://purl.obolibrary.org/obo/valid_for_go_ontology is_a: RO:0002233 ! has input is_a: RO:0004007 ! has primary input or output creation_date: 2018-12-13T11:26:56Z [Typedef] id: RO:0004046 name: causally upstream of or within, negative effect property_value: RO:0004050 RO:0002418 property_value: seeAlso "https://wiki.geneontology.org/Causally_upstream_of_or_within,_negative_effect" xsd:anyURI is_a: RO:0002418 ! causally upstream of or within creation_date: 2018-03-13T23:55:05Z [Typedef] id: RO:0004047 name: causally upstream of or within, positive effect property_value: seeAlso https://wiki.geneontology.org/Causally_upstream_of_or_within,_positive_effect is_a: RO:0002418 ! causally upstream of or within creation_date: 2018-03-13T23:55:19Z [Typedef] id: RO:0012000 name: has small molecule regulator def: "a relation between a process and a continuant, in which the process is regulated by the small molecule continuant" [] is_a: has_participant ! has participant inverse_of: RO:0012004 ! is small molecule regulator of creation_date: 2020-04-22T20:27:26Z [Typedef] id: RO:0012001 name: has small molecule activator def: "a relation between a process and a continuant, in which the process is activated by the small molecule continuant" [] is_a: RO:0012000 ! has small molecule regulator inverse_of: RO:0012005 ! is small molecule activator of creation_date: 2020-04-22T20:28:37Z [Typedef] id: RO:0012003 name: acts on population of def: "p acts on population of c iff c' is a collection, has members of type c, and p has participant c" [] subset: http://purl.obolibrary.org/obo/valid_for_go_annotation_extension subset: http://purl.obolibrary.org/obo/valid_for_go_ontology subset: http://purl.obolibrary.org/obo/valid_for_gocam is_a: has_participant ! has participant creation_date: 2020-06-08T17:21:33Z [Typedef] id: RO:0012004 name: is small molecule regulator of def: "a relation between a continuant and a process, in which the continuant is a small molecule that regulates the process" [] is_a: RO:0002596 ! capable of regulating creation_date: 2020-06-24T13:15:17Z [Typedef] id: RO:0012005 name: is small molecule activator of def: "a relation between a continuant and a process, in which the continuant is a small molecule that activates the process" [] property_value: seeAlso "https://wiki.geneontology.org/Is_small_molecule_activator_of" xsd:anyURI is_a: RO:0002598 ! capable of positively regulating is_a: RO:0012004 ! is small molecule regulator of creation_date: 2020-06-24T13:15:26Z [Typedef] id: RO:0012008 name: results in fusion of subset: http://purl.obolibrary.org/obo/valid_for_go_annotation_extension subset: http://purl.obolibrary.org/obo/valid_for_go_ontology subset: http://purl.obolibrary.org/obo/valid_for_gocam is_a: RO:0002592 ! results in organization of creation_date: 2021-02-26T07:28:29Z [Typedef] id: RO:0013001 name: has synaptic IO in region def: "A relationship between a neuron and a region, where the neuron has a functionally relevant number of input and/or output synapses in that region." [] synonym: "has synaptic input or output in" EXACT [] is_a: RO:0002130 ! has synaptic terminal in transitive_over: BFO:0000050 ! part of creation_date: 2020-07-17T09:26:52Z [Typedef] id: RO:0013007 name: has sensory dendrite in def: "Relation between a sensory neuron and some structure in which it receives sensory input via a sensory dendrite." [] synonym: "has sensory dendrite location" EXACT [] synonym: "has sensory terminal in" EXACT [] synonym: "has sensory terminal location" EXACT [] domain: CL:0000101 ! sensory neuron is_a: RO:0002360 ! has dendrite location transitive_over: BFO:0000050 ! part of creation_date: 2020-07-20T12:10:09Z [Typedef] id: RO:0015001 name: has exemplar data def: "A relation between a material entity and some data in which the data is taken as exemplifying the material entity." [] property_value: IAO:0000116 "C has_exemplar_data y iff x is an instance of C and y is data about x that is taken as exemplifying of C." xsd:string inverse_of: RO:0015002 ! exemplar data of transitive_over: RO:0015003 ! subcluster of [Typedef] id: RO:0015002 name: exemplar data of [Typedef] id: RO:0015003 name: subcluster of def: "A relation between a group and another group it is part of but does not fully constitute." [] property_value: IAO:0000116 "X subcluster_of Y iff: X and Y are clusters/groups; X != Y; all members of X are also members of Y." xsd:string is_transitive: true is_a: BFO:0000050 ! part of [Typedef] id: RO:0015004 name: has characterizing marker set def: "A relation that applies between a cell type and a set of markers that can be used to uniquely identify that cell type." [] synonym: "has marker gene combination" EXACT [] synonym: "has marker signature set" EXACT [] property_value: IAO:0000116 "C has_characterizing_marker_set y iff: C is a cell type and y is a collection of genes or proteins whose expression is sufficient to distinguish cell type C from most or all other cell types." xsd:string property_value: terms:contributor https://orcid.org/0000-0001-7258-9596 domain: CL:0000000 ! cell [Typedef] id: RO:0015006 name: different in magnitude relative to def: "q1 different_in_magnitude_relative_to q2 if and only if magnitude(q1) NOT =~ magnitude(q2). Here, magnitude(q) is a function that maps a quality to a unit-invariant scale." [https://orcid.org/0000-0002-6601-2165] domain: PATO:0000001 ! quality range: PATO:0000001 ! quality [Typedef] id: RO:0015007 name: increased in magnitude relative to def: "q1 increased_in_magnitude_relative_to q2 if and only if magnitude(q1) > magnitude(q2). Here, magnitude(q) is a function that maps a quality to a unit-invariant scale." [https://orcid.org/0000-0002-6601-2165] comment: This relation is used to determine the 'directionality' of relative qualities such as 'increased strength', relative to the parent type, 'strength'. domain: PATO:0000001 ! quality range: PATO:0000001 ! quality is_a: RO:0015006 ! different in magnitude relative to [Typedef] id: RO:0015008 name: decreased in magnitude relative to def: "q1 decreased_in_magnitude_relative_to q2 if and only if magnitude(q1) < magnitude(q2). Here, magnitude(q) is a function that maps a quality to a unit-invariant scale." [https://orcid.org/0000-0002-6601-2165] comment: This relation is used to determine the 'directionality' of relative qualities such as 'decreased strength', relative to the parent type, 'strength'. domain: PATO:0000001 ! quality range: PATO:0000001 ! quality is_a: RO:0015006 ! different in magnitude relative to [Typedef] id: RO:0015010 name: has relative magnitude [Typedef] id: RO:0015011 name: has cross section def: "s3 has_cross_section s3 if and only if : there exists some 2d plane that intersects the bearer of s3, and the impression of s3 upon that plane has shape quality s2." [https://orcid.org/0000-0002-6601-2165] comment: Example: a spherical object has the quality of being spherical, and the spherical quality has_cross_section round. [Typedef] id: RO:0015015 name: has high plasma membrane amount def: "A relation between a cell and molecule or complex such that every instance of the cell has a high number of instances of that molecule expressed on the cell surface." [PMID:19243617] property_value: terms:contributor https://orcid.org/0000-0003-1617-8244 property_value: terms:contributor https://orcid.org/0000-0003-1940-6740 domain: CL:0000000 ! cell is_a: RO:0002104 ! has plasma membrane part [Typedef] id: RO:0015016 name: has low plasma membrane amount def: "A relation between a cell and molecule or complex such that every instance of the cell has a low number of instances of that molecule expressed on the cell surface." [PMID:19243617] property_value: terms:contributor https://orcid.org/0000-0003-1617-8244 property_value: terms:contributor https://orcid.org/0000-0003-1940-6740 domain: CL:0000000 ! cell is_a: RO:0002104 ! has plasma membrane part [Typedef] id: RO:0017001 name: device utilizes material def: "X device utilizes material Y means X and Y are material entities, and X is capable of some process P that has input Y." [] synonym: "utilizes" BROAD [] property_value: terms:contributor https://orcid.org/0000-0001-9625-1899 property_value: terms:contributor https://orcid.org/0000-0003-2620-0345 holds_over_chain: RO:0002215 RO:0002233 creation_date: 2021-11-08T12:00:00Z [Typedef] id: RO:0020101 name: vessel supplies blood to def: "x vessel supplies blood to y if and only if x is a vessel that supplies blood directly or indirectly to an anatomical structure y." [] property_value: terms:contributor https://orcid.org/0000-0001-6677-8489 property_value: terms:date "2024-02-01T10:09:22Z" xsd:dateTime domain: UBERON:0001981 ! blood vessel range: UBERON:0000061 ! anatomical structure is_a: RO:0002178 ! supplies [Typedef] id: RO:0020102 name: vessel drains blood from def: "x vessel drains blood from y if and only if x is a vessel that drains blood directly or indirectly from an anatomical structure y." [] property_value: terms:contributor https://orcid.org/0000-0001-6677-8489 property_value: terms:date "2024-02-01T10:09:41Z" xsd:dateTime domain: UBERON:0001981 ! blood vessel range: UBERON:0000061 ! anatomical structure is_a: RO:0002179 ! drains [Typedef] id: RO:0020104 name: is neuron def: "This property only applies to neurons" [] property_value: terms:contributor https://orcid.org/0000-0001-6677-8489 property_value: terms:date "2024-10-23T14:34:52Z" xsd:dateTime domain: CL:0000540 ! neuron [Typedef] id: RO:0020105 name: is anatomical entity def: "This property only applies to anatomical entities." [] property_value: terms:contributor https://orcid.org/0000-0001-6677-8489 property_value: terms:date "2024-10-29T09:55:07Z" xsd:dateTime domain: UBERON:0001062 ! anatomical entity [Typedef] id: RO:0040036 name: results in changes to anatomical or cellular structure def: "p has anatomical participant c iff p has participant c, and c is an anatomical entity" [] is_a: has_participant ! has participant creation_date: 2018-09-26T01:08:58Z [Typedef] id: STATO:0000101 name: has numerator def: "the relationship between a fraction and the number above the line" [] is_asymmetric: true [Typedef] id: STATO:0000259 name: has denominator def: "the relationship between a fraction and the number below the line (or divisor)" [] [Typedef] id: anteriorly_connected_to name: anteriorly connected to def: "x anteriorly_connected_to y iff the anterior part of x is connected to y. i.e. x connected_to y and x posterior_to y." [http://purl.obolibrary.org/obo/uberon/docs/Connectivity-Design-Pattern] is_a: BSPO:0000099 is_a: RO:0002170 ! connected to is_a: transitively_anteriorly_connected_to ! transitively anteriorly connected to [Typedef] id: channel_for name: channel for synonym: "carries" BROAD [] domain: UBERON:0004111 ! anatomical conduit range: UBERON:0000463 ! organism substance [Typedef] id: channels_from name: channels_from is_transitive: true [Typedef] id: channels_into name: channels_into is_transitive: true [Typedef] id: distally_connected_to name: distally connected to def: "x distally_connected_to y iff the distal part of x is connected to y. i.e. x connected_to y and x proximal_to y." [http://purl.obolibrary.org/obo/uberon/docs/Connectivity-Design-Pattern] is_a: BSPO:0000100 is_a: RO:0002170 ! connected to is_a: transitively_distally_connected_to ! transitively distally connected to inverse_of: proximally_connected_to ! proximally connected to [Typedef] id: extends_fibers_into name: extends_fibers_into def: "X extends_fibers into Y iff there exists some neuron (N) and N has_soma_location X and N 'has synaptic IO in region' some Y" [https://orcid.org/0000-0002-7073-9172] is_symmetric: true is_a: RO:0002170 ! connected to [Typedef] id: filtered_through name: filtered through def: "Relationship between a fluid and a material entity, where the fluid is the output of a realization of a filtration role that inheres in the material entity." [] comment: Relationship between a fluid and a filtration barrier, where the portion of fluid arises as a transformation of another portion of fluid on the other side of the barrier, with larger particles removed [Typedef] id: has_high_plasma_membrane_amount name: obsolete has_high_plasma_membrane_amount def: "OBSOLETE A relation between a cell and molecule or complex such that every instance of the cell has a high number of instances of that molecule expressed on the cell surface. For the formal definition, see Masci et al (PMID:19243617)." [PMID:19243617] property_value: IAO:0000233 https://github.com/obophenotype/cell-ontology/issues/1481 is_obsolete: true replaced_by: RO:0015015 [Typedef] id: has_low_plasma_membrane_amount name: obsolete has_low_plasma_membrane_amount def: "OBSOLETE A relation between a cell and molecule or complex such that every instance of the cell has a low number of instances of that molecule expressed on the cell surface. For the formal definition, see Masci et al (PMID:19243617)." [PMID:19243617] property_value: IAO:0000233 https://github.com/obophenotype/cell-ontology/issues/1481 is_obsolete: true replaced_by: RO:0015016 [Typedef] id: has_participant name: has participant def: "a relation between a process and a continuant, in which the continuant is somehow involved in the process" [] xref: RO:0000057 property_value: IAO:0000116 "Has_participant is a primitive instance-level relation between a process, a continuant, and a time at which the continuant participates in some way in the process. The relation obtains, for example, when this particular process of oxygen exchange across this particular alveolar membrane has_participant this particular sample of hemoglobin at this particular time." xsd:string domain: BFO:0000003 range: BFO:0000002 holds_over_chain: BFO:0000051 has_participant [Typedef] id: indirectly_supplies name: indirectly_supplies def: "a indirectly_supplies s iff a has a branch and the branch supplies or indirectly supplies s." [] property_value: IAO:0000116 "add to RO" xsd:string holds_over_chain: RO:0002569 indirectly_supplies is_transitive: true [Typedef] id: layer_part_of name: layer part of is_a: BFO:0000050 ! part of [Typedef] id: posteriorly_connected_to name: posteriorly connected to def: "x posteriorly_connected_to y iff the posterior part of x is connected to y. i.e. x connected_to y and x anterior_to y." [http://purl.obolibrary.org/obo/uberon/docs/Connectivity-Design-Pattern] is_a: BSPO:0000096 is_a: RO:0002170 ! connected to [Typedef] id: protects name: protects [Typedef] id: proximally_connected_to name: proximally connected to def: "x proximally_connected_to y iff the proximal part of x is connected to y. i.e. x connected_to y and x distal_to y." [http://purl.obolibrary.org/obo/uberon/docs/Connectivity-Design-Pattern] is_a: BSPO:0000097 is_a: RO:0002170 ! connected to is_a: transitively_proximally_connected_to ! transitively proximally connected to [Typedef] id: results_in_distribution_of name: results in distribution of namespace: external xref: GOREL:0002003 [Typedef] id: results_in_fission_of name: results in fission of namespace: external xref: GOREL:0002004 is_a: has_participant ! has participant [Typedef] id: sexually_homologous_to name: sexually_homologous_to is_a: RO:0002158 ! shares ancestor with [Typedef] id: site_of name: site_of def: "c site_of p if c is the bearer of a disposition that is realized by a process that has p as part." [] synonym: "capable_of_has_part" RELATED [] [Typedef] id: subdivision_of name: subdivision of comment: placeholder relation. X = 'subdivision of A' and subdivision_of some B means that X is the mereological sum of A and B [Typedef] id: transitively_anteriorly_connected_to name: transitively anteriorly connected to property_value: seeAlso "http://purl.obolibrary.org/obo/uberon/docs/Connectivity-Design-Pattern" xsd:anyURI is_transitive: true [Typedef] id: transitively_distally_connected_to name: transitively distally connected to property_value: seeAlso "http://purl.obolibrary.org/obo/uberon/docs/Connectivity-Design-Pattern" xsd:anyURI is_transitive: true [Typedef] id: transitively_proximally_connected_to name: transitively proximally connected to property_value: seeAlso "http://purl.obolibrary.org/obo/uberon/docs/Connectivity-Design-Pattern" xsd:anyURI is_transitive: true [Typedef] id: trunk_part_of name: trunk_part_of is_a: BFO:0000050 ! part of